bluuebunny/crossref_metadata_2025_split huggingface dataset:
p53 protects against alcoholic fatty liver disease via ALDH2 inhibition
Authors: Yao Pengbo , Zhang Zhenxi , Liu Hongchao , Jiang Peng , Li Wei , Du Wenjing 
Published: February 2023

AbstractThe tumor suppressor p53 is critical for tumor suppression, but the regulatory role of p53 in alcohol‐induced fatty liver remains unclear. Here, we show a role for p53 in regulating ethanol metabolism via acetaldehyde dehydrogenase 2 (ALDH2), a key enzyme responsible for the oxidization of alcohol. By repressing ethanol oxidization, p53 suppresses intracellular levels of acetyl‐CoA and histone acetylation, leading to the inhibition of the stearoyl‐CoA desaturase‐1 (SCD1) gene expression. Mechanistically, p53 directly binds to ALDH2 and prevents the formation of its active tetramer and indirectly limits the production of pyruvate that promotes the activity of ALDH2. Notably, p53‐deficient mice exhibit increased lipid accumulation, which can be reversed by ALDH2 depletion. Moreover, liver‐specific knockdown of SCD1 alleviates ethanol‐induced hepatic steatosis caused by p53 loss. By contrast, overexpression of SCD1 in liver promotes ethanol‐induced fatty liver development in wild‐type mice, while it has a mild effect on p53−/− or ALDH2−/− mice. Overall, our findings reveal a previously unrecognized function of p53 in alcohol‐induced fatty liver and uncover pyruvate as a natural regulator of ALDH2.
LATE HOLOCENE CRYOGENIC DEFORMATIONS IN FLOODPLAIN SEDIMENTS OF RIVER VALLEYS IN THE SELENGA RIVER BASIN
Authors: РЫЖОВ Ю.В. , КОЛОМИЕЦ В.Л. , СМИРНОВ М.В. 
Published: February 2023

Дана характеристика криогенных деформаций (криотурбаций и грунтовых жил), их морфологии и возраста в голоценовых пойменных отложениях в бассейне р. Селенги в условиях сезонной, прерывистой, островной и редкоостровной многолетней мерзлоты в речных долинах. В разрезах пойменных отложений рек Итанца, Илька, Орхон выявлены позднеголоценовые грунтовые жилы и криотурбации в сезонномерзлом слое. Определено время формирования криогенных деформаций на основе детального изучения строения и датирования отложений низкой и высокой пойм рек Итанца, Илька, Орхон. Возраст аллювия с криотурбациями на низкой пойме моложе 2 тысяч лет. На высокой пойме криогенные деформации формировались в позднем голоцене (последние 4.2 тысячи лет). Установлено, что слои аллювия с криотурбациями постилаются влажными и мокрыми гумусированными супесями и суглинками. Криогенные деформации являются палеоклиматическим индикатором условий позднего голоцена Забайкалья, Северной и Центральной Монголии.
The morphology and age of cryogenic deformations (cryoturbations and ground wedges) in the Holocene floodplain sediments of river valleys in the Selenga River basin within the areas of seasonal, discontinuous, sporadic, and isolated permafrost were studied. Late Holocene ground wedges and cryoturbations were identified in the seasonally frozen layer of floodplain sections of the Itantsa, Il’ka, and Orkhon rivers. The time of formation of the cryogenic deformations was determined on the basis of detailed morphological descriptions and dating of low and high floodplain sediments of these rivers. The age of the alluvium with cryoturbation on the low floodplain is less than 2 kyr. Cryogenic deformations on the high floodplain formed in the Late Holocene (the last 4.2 kyr). It was determined that alluvium layers with cryoturbation are underlain by moderately wet to satiated wet loamy sands and loams. Cryogenic deformations are considered a paleoclimatic indicator of the Late Holocene in the Transbaikal region and northern and central Mongolia.
METHODOLOGY FOR ZONING THE TERRITORY OF LONG-DISTANCE LINEAR OBJECTS ACCORDING TO THERMOKARST FORMATION CONDITIONS
Authors: МАКАРЫЧЕВА Е.М. , МЕРЗЛЯКОВ В.П. , МИРОНОВ О.К. 
Published: February 2023

Определены причины неоднородности распространения термокарcта вдоль протяженных линейных объектов с применением вероятностно-статистического метода. Приведен перечень природных условий, влияющих на распространение термокарстовых явлений вдоль нефтепровода. Обоснована и разработана методика районирования буферной зоны протяженных линейных объектов (на примере магистрального нефтепровода) по условиям формирования явлений. Построены карты районирования буферной зоны магистрального нефтепровода по условиям, способствующим или препятствующим формированию термокарcта.
The probabilistic-statistical method is applied to study the causes of the thermokarst distribution heterogeneity along the long linear constructions. A list of natural conditions affecting the development of thermokarst along an oil pipeline is discussed. The methodology for zoning buffer area of long-distance linear constructions (e.g., oil pipeline) according to the conditions of thermokarst development is substantiated. We have delineated thermokarst-susceptible and thermokarst-tolerant areas along the oil pipeline buffer zone according to the environmental conditions.
YouTube X-Rating Detection with Bahasa-Slang Title Using Query Expansion and Rule Based Approaches
Authors: Wardani Dewi Wisnu , Shabihah Salsabila F 
Published: February 2023

The detection of X-rating content on the Internet is still rarely done in Indonesia and the performance of the existing work to detect X-rating content, especially in video is still low. The largest video portal, YouTube, does not yet have automatic X-rating content detection through its content either. Some X-rating content prevention service providers in Indonesia, such as the Internet Positive and Nawala Project, detect X-rating content using the keyword detection method of a web page and then block the web page with DNS filtering. However, that method does not pay attention to usingÂ Bahasa-Slang. This work developed Metasearch named Safedio. Safedio aims to detect X-rating content on YouTube content through video titles that contain Bahasa-Slang. Safedio utilizes Query Expansion and Rule-Based approaches. The Query Expansion is a technique to get additional rules in search. In the end, Safedio can detect X-rating content through video titles in both Bahasa and Bahasa-Slang. The average results return with precision 71%, recall 46% and accuracy 72%.
Earthquake source parameters and fault kinematics in the eastern California shear zone
Authors: Jones Laura E. , Helmberger Donald V. 
Published: February 2023

AbstractBased on waveform data from a profile of aftershocks following the north-south trace of the 28 June 1992 Landers rupture across the Mojave desert, we construct a new velocity model for the Mojave region that features a thin, slow crust. Using this model, we obtain source parameters, including depth and duration, for each of the aftershocks in the profile and, in addition, any significant (M &gt; 3.7) Joshua Tree-Landers aftershock between April 1992 and October 1994 for which coherent TERRAscope data were available. In all, we determine source parameters and stress drops for 45 significant (Mw &gt; 4) earthquakes associated with the Joshua Tree and Landers sequences, using a waveform grid-search algorithm. Stress drops for these earthquakes appear to vary systematically with location, with respect to previous seismic activity, proximity to previous rupture (i.e., with respect to the Landers rupture), and with tectonic province. In general, for areas north of the Pinto Mountain fault, stress drops of aftershocks located off the faults involved with the Landers rupture are higher than those located on the fault, with the exception of aftershocks on the newly recognized Kickapoo (Landers) fault. Stress drops are moderate south of the Pinto Mountain fault, where there is a history of seismic swarms but no single throughgoing fault. In contrast to aftershocks in the eastern Transverse ranges, and related to the 1992 Big Bear, California, sequence, Landers events show no clear relationship between stress drop and depth. Instead, higher stress-drop aftershocks appear to correlate with activity on nascent faults or those that experienced relatively small slip during mainshock rupture.
Faulting apparently related to the 1994 Northridge, California, earthquake and possible co-seismic origin of surface cracks in Potrero Canyon, Los Angeles County, California
Authors: Catchings R. D. , Goldman M. R. , Lee W. H. K. , Rymer M. J. , Ponti D. J. 
Published: February 2023

AbstractApparent southward-dipping, reverse-fault zones are imaged to depths of about 1.5 km beneath Potrero Canyon, Los Angeles County, California. Based on their orientation and projection to the surface, we suggest that the imaged fault zones are extensions of the Oak Ridge fault. Geologic mapping by others and correlations with seismicity studies suggest that the Oak Ridge fault is the causative fault of the 17 January 1994 Northridge earthquake (Northridge fault). Our seismically imaged faults may be among several faults that collectively comprise the Northridge thrust fault system. Unusually strong shaking in Potrero Canyon during the Northridge earthquake may have resulted from focusing of seismic energy or co-seismic movement along existing, related shallow-depth faults. The strong shaking produced ground-surface cracks and sand blows distributed along the length of the canyon. Seismic reflection and refraction images show that shallow-depth faults may underlie some of the observed surface cracks. The relationship between observed surface cracks and imaged faults indicates that some of the surface cracks may have developed from nontectonic alluvial movement, but others may be fault related. Immediately beneath the surface cracks, P-wave velocities are unusually low (&lt;400 m/sec), and there are velocity anomalies consistent with a seismic reflection image of shallow faulting to depths of at least 100 m. On the basis of velocity data, we suggest that unconsolidated soils (&lt;800 m/sec) extend to depths of about 15 to 20 m beneath our datum (&lt;25 m below ground surface). The underlying rocks range in velocity from about 1000 to 5000 m/sec in the upper 100 m. This study illustrates the utility of high-resolution seismic imaging in assessing local and regional seismic hazards.
Spectral inversion ofLgfrom earthquakes: A modified method with applications to the 1995, western Texas earthquake sequence
Authors: Xie Jiakang 
Published: February 2023

AbstractSpectral inversion of Lg from earthquake sources is subject to significant errors, due to random and systematic deviation of the Lg spectra from idealized theoretical models. I present an analysis of these errors and demonstrate that their effects tend to increase with decreasing frequency and recording distance. I propose modifications to the inverse method of Xie (1993) to reduce these errors. The modifications include a more robust Q estimator and the added capability of incorporating a priori knowledge into the inversion. The modified method is applied to Lg spectra from the 1995, western Texas earthquake (MW = 5.7). I measured average two-station Q values for selected station pairs, as well as the source rise time of the mainshock, with an empirical Green's function approach. These served as a priori knowledge for the simultaneous inversion for Lg seismic moment (M0), corner frequency (fc), and path Q. The result of the inversion indicates that Lg source radiation is nearly isotropic. The M0 and fc values estimated using Lg from the mainshock and two aftershocks are typical for Lg from central and eastern North American earthquakes, with M0 scaling with fc−4, and M0 and fc being 3.3 × 1016 N-m and 0.3 Hz, respectively, for the mainshock. The 1-Hz Lg Q correlates with tectonic environments, increasing from about 200 for westerly paths to above 700 for easterly paths. Two-station Q measurements suggest that, as previously discovered for Eurasia, the frequency dependence of Lg Q may be variable with distance if the distance spans a wide range (103 km).
The receiver structure beneath the Ebro basin, Iberian Peninsula
Authors: Julià Jordi , Vila Josep , Macià Ramon 
Published: February 2023

AbstractA model of the lithospheric structure of the eastern sector of the Ebro basin has been obtained by means of an inversion of the receiver functions from teleseismic events recorded by one of the Institut d'Estudis Catalans stations located at the northeastern Iberian Peninsula. The technique consists of the isolation and modeling of the amplitude and travel time of the direct P teleseismic wave reverberations in a local structure and has been used for events recorded at Poblet station (POB, placed in the southeast margin of the basin) from 1994 to 1997. The analysis of POB records shows the influence of large-scale heterogeneities in the wave pulses coming from azimuths crossing the Catalan Coastal Ranges, whereas a simple medium response is obtained when teleseismic waves only sample the basin. The inversion of such simple receiver functions in terms of a flat layered media (2- to 3-km layer thicknesses), along with a comparison of the results with previous and independent works, enables us to obtain a crustal and upper mantle velocity structure for the Ebro basin. The preferred solution models show a strong near-surface velocity gradient, a nearly constant P velocity upper crust of about 5.9 km/sec, and a sharp velocity contrast at the crust-mantle boundary located at 32 km depth overlayed by a lower crust consisting of a significant positive velocity gradient. The upper mantle shows an average P velocity of about 8.0 km/sec.
Reference functions of cyber incidents displaying in the media space
Authors: Lande Dmytro , Novikov Oleksii , Stopochkina Iryna 
Published: February 2023

The principles of cyber attacks detection that based on media content are described. Proposed methods are suitable for description of the general trends in the dynamics of information flows concerning cyber incidents. A generalized diagram of cyber attacks stages displaying in the media space is proposed. On the basis of the diagram the basic wavelet functions are selected, which can be considered as a reference for detecting cyber incidents. The proposed wavelets are low-order derivatives of Gaussian function (Wave, «Mexican Hat» and Morlaix wavelets). Retrospective analysis of already implemented information operations is a reliable way to verify them. The problem of forecasting is partly solved by probabilistic estimates in accordance with the type of reference functions.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 18.02.2023 г. по 24.02.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир 
Published: February 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по
COVID-19 за неделю с 18.02.2023 г. по 24.02.2023 г.
Genome-Wide Association Studies and fine-mapping of
genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in
Hispanic American and African American Cohorts
Authors: Yang Chaojie , Veenstra Jenna , Bartz Traci , Pahl Matthew , Hallmark Brian , Chen Yii-Der Ida , Westra Jason , Steffen Lyn , Brown Christopher , Siscovick David , Tsai Michael , Wood Alexis , Rich Stephen , Smith Caren , O'Connor Timothy , Mozaffarian Dariush , Grant Struan , Chilton Floyd , Tintle Nathan , Lemaitre Rozenn , Manichaikul Ani 
Published: February 2023

Abstract
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 x 10− 8, we confirmed association of the FADS signal and found evidence of two additional signals (in DAGLA and BEST1) within 200 kb of the originally reported FADS signal. Outside of the FADS region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including TMX2, SLC29A2, ANKRD13D and POLD4, and spanning a > 9 Mb region on chromosome 11 (57.5Mb ~ 67.1Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a POLD4 missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations.
Sensing of Disinfection Byproducts; An Iodo-Functionalized Metal-Organic Framework as a Platform
Authors: Amani Vahid , Norouzi Fataneh 
Published: February 2023

Abstract
A systematic sensing of halogenated disinfection byproducts (DBPs) has been studied for the first time in a un-/ functionalized UiO-67 MOFs. In this regard, an iodo-functionalized UiO-67 type metal-organic framework (MOF) (UiO-67(I)2) has been successfully synthesized via solvothermal reaction. The results show that the sensing response of the MOFs toward halogenated DBPs significantly increased by incorporation of halogen bonding (XB) functionalities. Noteworthy, in each class of DBPs, the sensing response of the considered MOFs regularly improved by moving from fluoro to iodo group; which precisely indicates that halogen bonding is in charge.
The impact of SnMnO2 TCO and Cu2O as an HTL on CIGSSe solar cell performance improvement
Authors: kumar Raushan , Priyadarshi Alok 
Published: February 2023

Abstract
This paper has simulated two experimental CIGSSe thin-film solar cells (TFSCs) having a high efficiency of 20% and 22.92%. Later validates the photovoltaics results of both devices based on the experiential values of optoelectronics data. After the simulation, a compelling result was confirmed for both the experimental and simulation solar cells. Finally, different designs have also been proposed. The proposed Type-1 solar cell is designed by the addition of low resistivity, wide energy bandgap (Eg), and minimum absorption coefficient (α) based tin-doped manganese oxide (Sn1 − xMnxO2) material in a conventional solar cell instead of ZnO: B and ZnMgO: Al transparent conducting oxides (TCO) layer. Further, by matching the band energy alignment and adjusting the thickness and doping concentration of the TCO, buffer, and absorber layers, the efficiency of the proposed Type-1 TFSC has been increased from 20 to 27.75%. The proposed Type-1 solar cell has some drawbacks, such as the inability to appropriately suppress the photogenerated minority carrier recombination losses due to the absence of a hole transport layer (HTL), and the EQE is relatively lesser than the conventional solar cell. Furthermore, wide band energy and a high ‘α’ based on cuprous oxide (Cu2O) as a HTL are added between the absorber and the back ohmic contact layers in the proposed Type-1 solar cell. Then the structure becomes a proposed Type-2 TFSC. The proposed Type-2 TFSC absorbs more blue light, instantly suppressing the recombination losses and enhancing efficiency (29.01%) and EQE (97%).
Antagonistic fatigue crack propagation in Ni-based superalloy 718 under hydrogen-supply: Acceleration and deceleration phenomena
Authors: Takakuwa Osamu , Ogawa Yuhei , Miyata Ryunosuke 
Published: February 2023

Abstract
Mechanical properties of structural alloys, including Ni-based superalloy 718 (Alloy718), are degraded when hydrogen (H) is supplied: hydrogen embrittlement (HE). The presence of H notably deteriorates fatigue crack growth (FCG) property, which renders the growth rate much higher and shortens the lifetime of the components operating in the hydrogenating environment. Hence, the mechanisms behind such acceleration phenomenon in FCG should be understood comprehensively toward developing promising alloys resistant to hydrogen occlusion. In particular, Alloy718 has a meager resistance to HE, even regularly displaying superior mechanical and physical performances. Notwithstanding, the present study unveiled that the FCG acceleration by dissolved H in Alloy718 can be negligible. An abnormal deceleration of FCG can instead be pronounced by optimizing the metallurgical state, a hopeful prospect in Ni-based alloys applied to the hydrogenating environment.
Different food coping strategies in urban and semi-urban areas during Coronavirus Disease 2019 (COVID-19) pandemic
Authors: Fikawati Sandra , Syafiq Ahmad , Notarianti Rizna , Gemily Syilga Cahya 
Published: February 2023

Abstract

Background: Consumption-related behavior implemented as an effort to maintain household food security is referred to as a food coping strategy (FCS). This study aims to describe the selection of FCS by families in urban and semi-urban areas in Indonesia.
Method: This research is a cross-sectional study with a total sample of 517 people who live in urban (Jakarta) and semi-urban (Depok) areas. The research data was taken from primary research data that had been collected online and purposively through Posyandu cadres who had access to family/community. Data analysis used the chi-square test and multiple logistic regression.
Results: More households in urban areas apply food security coping strategies (69%) compared to semi-urban areas (59.8%) In semi-urban areas, changes occur gradually from the lightest to the heaviest. Meanwhile, in urban areas, there were more severe strategies chosen, namely switching to other staple foods (78.7%), reducing eating in adults (75.3%), and reducing the frequency of eating (71.9% which is higher than reducing food portions (70, 2%). Results of multivariate analysis showed that the level of household food security (AOR = 12.182; 95% CI = 7.636 – 19.434) and spouse's education (AOR = 2.184; 95% CI = 1.091 – 4.375) were significantly related to the application of household FCS after being controlled by spouse's employment status, the number of working household members, household head’s education and household head’s income.
Conclusion: The low level of household food security during the COVID-19 pandemic and the impact of the COVID-19 pandemic on people's jobs and income have caused households to adapt by implementing several types of FCS.
Contrasting allelic effects for pistachio salinity tolerance in juvenile and mature trees
Authors: Sheikhi Abdollatif , Arab Mohammad , Palmer William , Michelmore Richard , Brown Pat 
Published: February 2023

Abstract
Breeding perennial tree crops often requires prediction of mature performance from juvenile data. To assess the utility of juvenile screens to predict salinity tolerance of mature pistachio trees, we compared performance of three-month ungrafted seedlings and four-year-old grafted rootstocks under salinity stress. The QTL allele associated with higher salt exclusion from seedling leaves conferred lower growth in saline field conditions, cautioning that mapping QTL in seedlings may be easier than discerning the optimal allele for field performance.
Predicting Rejection of Emerging Contaminants through RO Membrane Filtration based on ANN- QSAR Modeling Approach: Trends in Molecular Descriptors and Structures towards Rejections
Authors: Mousavi Setare Loh , Sajjadi Seyedeh Maryam 
Published: February 2023

Abstract
In this work, a quantitative structure-activity relationship (QSAR) study was performed on a set of emerging contaminants (ECs) to predict their rejections by reverse osmosis membrane (RO). A wide range of molecular descriptors was calculated by Dragon software for 72 ECs. The QSAR data was analyzed by an artificial neural network method (ANN), in which four out of 3000 descriptors were chosen and their significance was computed. The significance trends of descriptors were as follows in descending order: ESpm14u > R2e > SIC1 > EEig03d. For the first time, an explorative study was conducted on the QSAR data to show the trends in molecular descriptors and structures toward the rejections values of ECs. Moreover, the MLR algorithm was used to make a linear model and the results were compared with those of the nonlinear ANN algorithm. The comparison results revealed it is necessary to apply the ANN model to this data with non-linear properties.