bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway
Authors: Wang Fei , Mu Hai-Feng , Wang Chun , Tang Yue , Si Ming-Yuan , Peng Jing 
Published: January 2025

BACKGROUND
Colonic neuroendocrine carcinomas (NECs) are highly malignant and invasive with poor prognosis. Long noncoding RNAs (LncRNAs) participate in the tumorigenesis and metastasis of multiple cancers
AIM
To detect the roles and mechanisms of lncRNA prostate cancer associated transcript 6 (PCAT6) in the progression of colonic NEC.
METHODS
Human NEC and adjacent normal samples were collected for immunohistochemistry staining of CgA and real-time quantitative polymerase chain reaction (RT-qPCR) of PCAT6 mRNA level. Subcutaneous xenograft tumor model and lung metastasis model were established in nude mice. The lung tissues were stained by hematoxylin and eosin to assess pulmonary metastasis. The expression of epithelial-mesenchymal transition (EMT)-related markers and pathway-related genes was measured by RT-qPCR and western blotting. CD56 expression was assessed by immunofluorescence staining. The biological functions of PCAT6 were examined by cell counting kit-8, colony formation assays, Transwell assays and wound healing assays. The interaction between PCAT6 and its potential downstream target was verified by luciferase reporter assays.
RESULTS
LncRNA PCAT6 was upregulated in human NEC samples and LCC-18 cells, and its high expression was positively correlated with poor prognosis in patients with colonic NEC. Additionally, the expression of PCAT6 was positively associated with the proliferation, migration, invasion, and EMT of LCC-18 cells. Moreover, PCAT6 facilitated tumor growth, lung metastasis and EMT in xenografts. Mechanistically, PCAT6 promoted the activation of MAPK to enhance the EMT in colonic NEC by targeting miR-326.
CONCLUSION
In conclusion, lncRNA PCAT6 accelerates the process of colonic NEC by activating ERK/p38 MAPK signaling through targeting miR-326. These results might provide useful information for exploring the potential therapeutic targets in colonic NEC.
Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma
Authors: Nie Ai-Yu , Xiao Zhong-Hui , Deng Jia-Li , Li Na , Hao Li-Yuan , Li Sheng-Hao , Hu Xiao-Yu 
Published: January 2025

BACKGROUND
Hepatocellular carcinoma (HCC) ranks as the fourth leading cause of cancer-related deaths in China, and the treatment options are limited. The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) activates the stimulator of interferon gene (STING) signaling pathway as a crucial immune response pathway in the cytoplasm, which detects cytoplasmic DNA to regulate innate and adaptive immune responses. As a potential therapeutic target, cGAS-STING pathway markedly inhibits tumor cell proliferation and metastasis, with its activation being particularly relevant in HCC. However, prolonged pathway activation may lead to an immunosuppressive tumor microenvironment, which fostering the invasion or metastasis of liver tumor cells.
AIM
To investigate the dual-regulation mechanism of cGAS-STING in HCC.
METHODS
This review was conducted according to the PRISMA guidelines. The study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science databases. Through rigorous screening and meticulous analysis of the retrieved literature, the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC tumors.
RESULTS
All authors collaboratively selected studies for inclusion, extracted data, and the initial search of online databases yielded 1445 studies. After removing duplicates, the remaining 964 records were screened. Ultimately, 55 articles met the inclusion criteria and were included in this review.
CONCLUSION
Acute inflammation can have a few inhibitory effects on cancer, while chronic inflammation generally promotes its progression. Extended cGAS-STING pathway activation will result in a suppressive tumor microenvironment.
Investigating Teacher Performance in Character Building Students: a Case Study of Teaching and Learning at an Elementary School in Indonesia
Authors: Sauri Sofyan , Sanusi Anwar 
Published: January 2025

Objective: This study aims to investigate the performance of teachers in the formation of student character through the implementation of learning in elementary schools.

Theoretical Framework: Primary schools are the initial foundation for building the character of students. If character cultivation fails to be carried out at the elementary education age stage, the character instilled in students will inevitably be less than optimal. For that, the theory used is an approach a communitarian ethos refers to a method of school organization that promotes the formation of deep emotional relationships between children and instructors as well as professional staff relational trust.

Method: The method used is a qualitative method with the type of case study. The research data collection techniques were obtained through interviews, observation, and documentation studies.

Results and Discussion: The results of this study reveal three findings, namely: 1) What character values are taught, and 2) How are character values taught by teachers in schools from the perspective of teachers, students, and parents? This finding has important meaning for academics, practitioners, and policymakers, in how character education is applied in schools.

Research Implications: Researchers for teachers can be used as a source of guidance for better behavior in accordance with the expected characteristics so that they can become good examples for their students. Principals and teachers should remind each other to continuously assist students in guiding, motivating, directing, and educating their students to maintain good character in the school, family, or community environment.

Originality/Value: This study is one of the references for teachers to be used as a reference to behave better in accordance with the expected character. This study is also important for the Principal to remind the teacher's responsibilities and obligations in order to form students with character.
Enhancing Job Satisfaction Among Lawyers in the Maldives Through Work-Life Balance: a Contribution to SDG 8
Authors: Naeem Shafeega , Jusoh Mazuki , Khatibi Ali , Azam S. M Ferdous 
Published: January 2025

Objective: The study investigates the relationship between work-life balance and job satisfaction of public-sector lawyers. This study aligns with The UNITED NATION’s (UN) Sustainable Development Goal 8 (DECENT WORK AND ECONOMIC GROWTH) by focusing on the critical factors of work-life balance and job satisfaction, which directly influence mental health and overall well-being in the workplace.

Theoretical Framework: This paper provides a brief overview and significance of work-life balance, and job satisfaction, particularly in the context of organizational research, with a focus on lawyers in the public sector in the Maldives. The two factor theory, and work-life balance model related to work-life balance and job satisfaction provides a foundation to understand the interplay roles between the variables.

Method: The study utilized a quantitative plan with a cross-sectional data collection approach. Data was collected from 218 lawyers from public sector in the Maldives utilizing a survey questionnaire.

Results and Discussion: The findings from this study showed a significant relationship between work-life balance and job satisfaction. The result highlights the important role of work-life balance in enhancing job satisfaction, underlining the importance for decent work and economic growth.

Research Implications: The research emphasizes the importance of creating decent and supportive work environments for lawyers in the Maldives’ public sector, which can help improve work-life balance, and improve job satisfaction of lawyers. The findings provide important implications for organizations in further developing the policies of the organizations where lawyers work. These efforts offer practical implications to achieve SDG 8 by adopting strategies that support workplace culture and well-being of lawyers in the Maldives.

Originality/Value: This study contributes to the literature by focusing on public-sector lawyers in the Maldives, an unexplored area about lawyers, examining job satisfaction as a dependent variable and work-life balance as independent variable. The research underlines the importance of aligning organizational strategies with global goals such as SDG 8 to promote sustained, full and productive employment and decent work for all.
The Impact of the COVID-19 Pandemic on Cultural Tourism in the Republic of Kosovo: Decent Work and Economic Growth
Authors: Arifović Zahir , Škrijelj Hajrija , Zenelaj Bariu , Mehovic Sead 
Published: January 2025

Objective: This study investigates the impact of the COVID-19 pandemic on the cultural sector in Kosovo, aiming to identify challenges, assess recovery strategies, and propose measures for sustainable development. It highlights the role of culture in fostering resilience, well-being, and social cohesion during crises.

Theoretical Framework: The research is based on theories of cultural resilience, creative economy, and crisis management. These frameworks provide insights into the cultural sector’s vulnerabilities and its potential as a driver for societal recovery and transformation.

Method: A qualitative, exploratory approach was employed, utilizing direct surveys, semi-structured interviews, and document analysis. Data were gathered from stakeholders in the formal cultural sector and the independent cultural scene to evaluate their experiences and needs during the pandemic. A SWOT analysis further structured the findings.

Results and Discussion: The study reveals significant financial, infrastructural, and operational challenges for the cultural sector during the pandemic, alongside a lack of institutional support. However, it also identifies opportunities for innovation, digitalization, and collaboration. These results are discussed within the context of the theoretical framework, with practical recommendations to address weaknesses and leverage strengths for recovery.

Research Implications: The study emphasizes the urgency of targeted government support, enhanced public policies, and sustainable funding mechanisms to revitalize Kosovo’s cultural sector. It also highlights culture’s critical role in mental health, community resilience, and economic recovery.

Originality/Value: By providing a comprehensive analysis of Kosovo’s cultural sector during a global crisis, this research offers practical recommendations and contributes to broader discussions on cultural resilience and sustainable development in similar contexts globally.
Evaluation of Medical Diagnosis Capabilities of Three Artificial Intelligence Models – ChatGPT-3.5, Google Gemini, Microsoft Copilot: Sustainable Development Goals (SDGs)
Authors: Eneva Yordanka , Dogan Bora 
Published: January 2025

Objectives: This study aims to assess and compare the diagnostic accuracy of three artificial intelligence (AI) models—ChatGPT-3.5, Microsoft Copilot, and Google Gemini—through their performance on clinical vignettes.

Theoretical Framework: Building on prior research into the application of AI in healthcare, particularly in diagnostic support, this study examines the potential of AI models to aid clinicians by providing accurate medical diagnoses, thus supporting decision-making in clinical contexts.

Methodology: A meta-analysis was conducted, followed by a comparative analysis using 34 clinical vignettes from Texas Tech University Health Sciences Center. Each AI model’s responses were evaluated for accuracy in diagnosing medical cases, and statistical significance was tested using the chi-square test.

Results and Discussion: ChatGPT-3.5 achieved the highest diagnostic accuracy (70.59%), outperforming Google Gemini (61.76%) and Microsoft Copilot (35.29%). ChatGPT-3.5 provided concise answers, while Google Gemini and Microsoft Copilot included disclaimers and additional recommendations. Chi-square analysis confirmed significant differences in performance, highlighting variations in diagnostic capabilities across models.

Research Implications: These findings underscore the importance of model selection when integrating AI into clinical workflows. AI models show promise in diagnostics but vary in approach and accuracy, warranting further refinement.

Originality/Value: This study is among the first to compare the diagnostic accuracy of ChatGPT-3.5, Google Gemini, and Microsoft Copilot, contributing valuable insights into AI’s application in healthcare diagnostics and supporting evidence for its potential role in enhancing patient care.
Intellectual Capital and Maqashid Sharia Performance of Islamic Banking in Indonesia: the Moderate of Islamic Sustainable Development Goals (SDGs)
Authors: Arif Widyantono , Habbe Abdul Hamid , Rasyid Syarifuddin , Madein Afdal 
Published: January 2025

Objective: This study aims to obtain empirical evidence on the influence of intellectual capital on the performance of maqashid sharia with Islamic Sustainable Development Goals (SDGs) as a moderating variable.

Theoretical Framework: This research is based on resource-based theory (RBT), legitimacy theory and maqashid sharia theory.

Method: The iB-VAIC method for intellectual capital is measured based on capital employed, human capital, and structural capital. This study also uses a moderating variable, namely the disclosure of sustainable development goals (SDGs) of the type of Islamic corporate social responsibility (iCSR). The bank performance variable is measured using the maqashid sharia approach that Mohammed & Taib (2015) developed. Secondary data in the form of annual reports of 9 Islamic commercial banks in Indonesia were collected from 2015-2020 and analyzed using multiple regression analysis.

Results and Discussion: The research results show that (1) intellectual capital has a negative effect on the performance of maqashid sharia, (2) the amount of Islamic corporate social responsibility (iCSR) disclosure has a positive effect as a moderating variable in the relationship between intellectual capital and maqashid sharia performance.

Research Implications: These findings can help Islamic bank managers improve their corporate performance by effectively utilizing their iCSR and IC.

Originality/Value: To our knowledge, this is the first study to examine the influence of intellectual capital on maqashid sharia performance by using disclosure of Islamic sustainable development goals (SDGs) of the type of Islamic corporate social responsibility as a moderation variable in the Islamic banking context in Indonesia.
Poverty Alleviation in the Local Economy to Achieve Sustainable Development Goals
Authors: Sriyana Jaka 
Published: January 2025

Objective: This paper examines the strategies of poverty alleviation based on data from the regions in the Daerah Istimewa Yogyakarta province, Indonesia, to achieve the Sustainable Development Goals category of No Poverty (SDGS 1).

Theoretical Framework: This study applies the multidimensional poverty theory, explaining that poverty depends on many factors. This research proposes that the determinants of poverty rate are economic growth, wage level, unemployment, human resources quality, and government spending.

Method: This study estimates a poverty model based on panel data of regencies from 2014 to 2023. The estimation follows the standard procedure of the panel regression analysis.

Results and Discussion: The results show that this region's poverty rate relates to economic growth, minimum wage, human resource quality, and local government spending. The research finds that local governments have successfully alleviated poverty by maintaining the minimum wage policy, effective human resource development programs, and allocating their spending to lower poverty. This study highlights that local governments are on the right path in their public policies regarding poverty alleviation.

Research Implications: To alleviate poverty more effectively, regency governments should continue the minimum wage policy and manage their spending correctly to improve the quality of human resources.

Originality/Value: The originality of this study lies in poverty alleviation strategies based on the case of regencies. Other local governments across countries may refer to this finding in their poverty alleviation programs.
A Review the Role of Artificial Intelligence in Media Content Creation for SDGs Development
Authors: Shao Yang , Yin Qingxia 
Published: January 2025

Introduction: The rapid advancement of Artificial Intelligence (AI) has significantly transformed digital media content creation, particularly with the rise of AI-Generated Content (AIGC). This systematic review investigates AIGC's role in enhancing content production efficiency, improving content quality, and addressing ethical considerations. AIGC applications—spanning micro-video production, digital storytelling, journalism, and new media art—highlight its profound impact on content workflows, distribution, and audience engagement.

Objective: The objective of this study is to explore how AIGC influences the efficiency, quality, and ethical standards of digital media content creation, with the aim of fostering responsible and sustainable integration of AIGC in the media industry.

Theoretical Framework: This research is grounded in theories of human-machine interaction, ethical decision-making, and technological adoption models, which provide a solid foundation for examining the dynamics of AIGC in the context of Web 3.0 advancements.

Method: The methodology employed for this review involved a systematic analysis of scholarly articles, case studies, and industry reports on AIGC. The data were synthesized to evaluate its transformative potential, ethical challenges, and alignment with sustainable development goals (SDGs).

Results and Discussion: The findings reveal that AIGC significantly enhances efficiency and scalability in content production while raising ethical concerns such as professional displacement and algorithmic biases. These results are contextualized within the theoretical framework, emphasizing the need for ethical safeguards and inclusive practices. Challenges, including transparency in AI use and equitable access to AIGC technologies, are also discussed.

Research Implications: This study offers both theoretical and practical implications by proposing strategies for responsible AIGC adoption, contributing to the sustainable development of the digital media industry. Implications include its potential to democratize content creation, foster inclusivity, and support SDGs such as Quality Education (SDG 4), Decent Work and Economic Growth (SDG 8), and Industry, Innovation, and Infrastructure (SDG 9).

Originality/Value: This study provides a novel contribution to the literature by integrating SDG-oriented perspectives into the discussion of AIGC's impact. Its findings underline the critical balance between leveraging technological advancements and mitigating their societal and ethical challenges.
Assessing the Impact of Intangible Cultural Heritage Cognition on Sense of Place Among Urban Residents in Dalian Under Sustainable Development Goals
Authors: Guo Lifang , Kim Eunyoung 
Published: January 2025

Objective: The objective of this study is to evaluate the impact of urban residents' intangible cultural heritage cognition on their sense of place with the aim of to providing empirical support for promoting intangible cultural heritage and enhancing the sustainability of urban culture.

Theoretical Framework: Based on the sense of place theory. He sense of place embodies a deep emotional connection between people and places, a special human-place relationship transformed by cultural and social characteristics.

Method: This research mainly adopts quantitative analysis method. Data collection was conducted through questionnaires. Data of Dalian residents were collected to determine the dimensions of urban residents' intangible cultural heritage cognition through exploratory factor analysis, and the impact of these dimensions on urban residents' sense of place was assessed through regression analysis.

Results and Discussion: The results show that residents' perception of intangible cultural heritage significantly affects their sense of place. In addition, demographic variables such as gender, age, and length of residence also affect urban residents' sense of place.

Research Implications: The study found that improving residents' awareness of intangible cultural heritage can help enhance residents' sense of place, and based on this, recommendations are made for the government and relevant cultural institutions.

Originality/Value: This study provides empirical support for improving residents' sense of local identity through the recognition of intangible cultural heritage and provides a reference for realizing the sustainable development goal of urban cultural construction.
Digital Transformation for Economic Growth and SDG 8 Alignment in Southeast Asia: a Bibliometric Analysis and Systematic Literature Review with ADO-TCM Framework
Authors: Hermawan Jessica , Wijaya Liliana Inggrit , Rianawati Andri 
Published: January 2025

Objective: This study investigates the role of digitalization in fostering economic growth and sustainability among Southeast Asian companies, aiming to map research gaps and explore future research directions while aligning with SDG 8, which promotes inclusive, sustainable economic growth.

Theoretical Framework: The study employs PRISMA and utilizes the ADO-TCM framework to analyze the antecedents, decisions, and outcomes of digital transformation in the region.

Method: A bibliometric analysis and Systematic Literature Review (SLR) were conducted on 165 articles from Scopus (2013–2023), categorized using the ADO-TCM framework.

Results and Discussion: The findings identify key drivers of digital transformation, including government policies and Industry 4.0, with strategic decisions focusing on digital infrastructure, agility, and stakeholder engagement. Outcomes include improved sustainability, competitiveness, and digital skills. The study highlights research gaps in under-explored industries like the blue economy and agriculture, as well as inconsistencies in methodologies.

Research Implications: Policymakers should support SME digitalization through improved infrastructure to drive business sustainability, create jobs, and reduce poverty, contributing to SDG 8. Future studies should explore neglected industries using mixed-method approaches.

Originality/Value: By combining the ADO and TCM frameworks, this study offers novel insights into digital transformation and its alignment with SDG 8, providing practical and theoretical value for sustainable growth in Southeast Asia.