bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated analysis identifies microRNA‐188‐5p as a suppressor of AKT/mTOR pathway in renal cancer
Authors: Shen Hui , Jin Jing , Wang Hang , Yu Nanxi , Liu Tingting , Sheng Han , Wan Zhijie , Feng Chao , Huang Yijuan , Gao Fu 
Published: May 2023

AbstractMany current microRNA (miRNA) expression datasets for renal cell carcinoma (RCC) often show inconsistent analysis results, so a shift to comprehensive analysis of multiple datasets can effectively accelerate molecular screening for precision medicine and translational medicine research. MicroRNA (miR)‐188‐5p is a clinically noteworthy miRNA whose aberrant expression was previously observed in a variety of cancers, but its role in RCC is unclear. In this study, we undertook a comprehensive analysis of four RCC miRNA expression datasets and validated the results using The Cancer Genome Atlas (TCGA) dataset and a cohort of collected clinical samples. Fifteen miRNAs were identified as potential diagnostic markers by the analysis of four RCC miRNAs datasets. Analysis of the TCGA kidney renal clear cell carcinoma dataset showed significantly shorter survival in RCC patients with reduced miR‐188‐5p expression levels, and our collection of RCC clinical samples showed low miR‐188‐5p expression in the tumors. Overexpression of miR‐188‐5p in Caki‐1 and 786‐O cells inhibited cell growth, colony formation, invasion, and migration. In contrast, miR‐188‐5p inhibitors reversed these cell phenotypes. We identified a binding site for miR‐188‐5p in the 3′‐UTR region of myristoylated alanine‐rich C‐kinase substrate (MARCKS) mRNA and demonstrated an interaction between these two molecules. Quantitative RT‐PCR and western blot analysis revealed that miR‐188‐5p could regulate the AKT/mTOR signaling pathway through MARCKS. Mouse transplantation tumor assay indicated that miR‐188‐5p reduced the tumorigenicity of RCC in vivo. MicroRNA‐188‐5p could be a valuable new molecule for RCC diagnosis and prognosis.
From health inequalities to health justice in 50 years
Authors: Venkatapuram Sridhar , Marmot Michael 
Published: May 2023

AbstractIn the following discussion, we present a quick conceptual history of healthy equity and health justice, some plausible outcomes from the Covid‐19 pandemic for the public’s understanding of these concepts, and some recent and relevant learnings for realizing equity and justice that could be useful for dental public health and beyond.
Natural dyeing of air plasma‐treated wool fabric with Rubia tinctorum L. and prediction of dyeing properties using an artificial neural network
Authors: Eyupoglu Can , Eyupoglu Seyda , Merdan Nigar , Omerogullari Basyigit Zeynep 
Published: May 2023

AbstractIn this study, the ecological dyeing process of wool fabrics was investigated. Wool fabric samples were treated with atmospheric pressure plasma‐jet and corona discharge plasma to modify the surface to make the process sustainable and greener. The samples were dyed with the aqueous extract procured from the powdered roots of Rubia tinctorum L. (madder) using the ultrasonic‐assisted method. Scanning electron microscopy and Fourier Transform–infrared analysis were performed to investigate the effect of plasma treatment on the physical and chemical properties of wool fibres. The effects of plasma treatment type, plasma treatment parameters and the duration of dyeing on colorimetric and fastness properties were investigated. The etching of the wool fibre surface and roughness after plasma treatment were proven with scanning electron microscopy images. The Fourier Transform–infrared spectra showed that no significant differences in the functional groups of wool fibre occurred after plasma treatment. The experimental results proved that plasma treatment parameters and dyeing time had an effect on the colorimetric and fastness properties of the samples. Furthermore, an artificial neural network model was proposed for estimating the dyeing properties of wool fabrics, namely, L, a, b, K/S, colour change, rubbing fastness (dry) and rubbing fastness (wet). The experimental results show that the proposed model achieves regression values greater than 0.97 for all dyeing properties. The proposed model is successful and can be efficiently used for estimating the dyeing characteristics of wool fabrics.
3D bioprinting microgels to construct implantable vascular tissue
Authors: Wang Xinhuan , Liu Xin , Liu Wenli , Liu Yanyan , Li Ailing , Qiu Dong , Zheng Xiongfei , Gu Qi 
Published: May 2023

AbstractEngineered implantable functional thick tissues require hierarchical vasculatures within cell‐laden hydrogel that can mechanically withstand the shear stress from perfusion and facilitate angiogenesis for nutrient transfer. Yet current extrusion‐based 3D printing strategies are unable to recapitulate hierarchical networks, highlighting the need for bioinks with tunable properties. Here, we introduce an approach whereby crosslinkable microgels enhance mechanical stability and induce spontaneous microvascular networks comprised of human umbilical cord vein endothelial cells (HUVECs) in a soft gelatin methacryoyl (GelMA)‐based bioink. Furthermore, we successfully implanted the 3D printed multi‐branched tissue, being connected from the rat carotid artery to the jugular vein direct surgical anastomosis. The work represents a significant step toward in the field of large vascularized tissue fabrication and may have implications for the treatment of organ failure in the future.
Collagenase treatment decreases muscle stiffness in cerebral palsy: A preclinical ex vivo biomechanical analysis of hip adductor muscle fiber bundles
Authors: Howard Jason J. , Joumaa Venus , Robinson Karyn G. , Lee Stephanie K. , Akins Robert E. , Syed Faizan , Shrader M. Wade , Huntley James S. , Graham H. Kerr , Leonard Timothy , Herzog Walter 
Published: May 2023

AbstractAimTo determine the dose–response relationship of collagenase Clostridium histolyticum (CCH) on collagen content and the change in muscle fiber bundle stiffness after ex vivo treatment of adductor longus biopsies with CCH in children with cerebral palsy (CP).MethodBiopsy samples of adductor longus from children with CP (classified in Gross Motor Function Classification System levels IV and V) were treated with 0 U/mL, 200 U/mL, 350 U/mL, or 500 U/mL CCH; percentage collagen reduction was measured to determine the dose–response. Peak and steady‐state stresses were determined at 1%, 2.5%, 5%, and 7.5% strain increments; Young's modulus was calculated.ResultsEleven patients were enrolled (nine males, two females, mean age at surgery 6 years 5 months; range: 2–16 years). A linear CCH dose–response relationship was determined. Peak and steady‐state stress generation increased linearly at 5.9/2.3mN/mm2, 12.4/5.3mN/mm2, 22.2/9.7mN/mm2, and 33.3/15.5mN/mm2 at each percentage strain increment respectively. After CCH treatment, peak and steady‐state stress generation decreased to 3.2/1.2mN/mm2, 6.5/2.9mN/mm2, 12.2/5.7mN/mm2, and 15.4/7.7mN/mm2 respectively (p < 0.004). Young's modulus decreased from 205 kPa to 100 kPa after CCH (p = 0.003).InterpretationThis preclinical ex vivo study provides proof of concept for the use of collagenase to decrease muscle stiffness in individuals with CP.
Family‐supportive supervisor behaviours: The role of relational resources in work and home domains
Authors: Ererdi Can , Rofcanin Yasin , Las Heras Mireia , Barraza Maria , Wang Siqi , Bakker Arnold , Bosch Maria Jose , Berber Aykut 
Published: May 2023

AbstractThis study explores the nomological network of family‐supportive supervisor behaviours (FSSBs) at the weekly level. Drawing on the tenets of the work–home resources (W‐HR) model and the conservation of resources theory, we integrate relational resources in the model and investigate their role as triggers of FSSBs. Furthermore, we explore how FSSBs relate to both within domain (production deviance and employee creativity) and between domain (sleep quality and dyadic adjustment) employee outcomes, with a focus on exhaustion as a mediator. Our findings show that (1) spousal support experienced by the supervisor is positively related to the employee's perception of FSSBs as enacted by the supervisor, (2) employees' perceptions of FSSBs are negatively related to employees' production deviance and (3) exhaustion is a mediator between FSSBs and employee outcomes of creativity, sleep quality and dyadic adjustment. Our findings across two multisource and diary studies underline the importance of designing and implementing FSSBs in a dynamic fashion.
Disgruntled cadres: How tax reduction undermines rural governance
Authors: Hou Linke , Liu Mingxing , Lü Xiaobo 
Published: May 2023

AbstractTax reduction is supposed to garner popular support, yet rural unrest sharply increased following the Chinese government's agricultural tax reform aiming to reduce peasants' tax burden. We argue that the tax reduction could undermine village elites' economic and political incentives to assist the state in implementing unpopular policies and achieving desirable outcomes. We exploit the exogeneous timing of the agricultural tax reform that abolished the agriculture tax and estimate its impact through a rare national representative village‐level panel dataset. We demonstrate that the tax reform led to tax noncompliance and rising social unrest. We further show that local governance worsened because village elites were disincentivized from carrying out state‐preferred yet unpopular policies.
Degree of crypt atypia correlates with progression to high‐grade dysplasia/adenocarcinoma in non‐dysplastic Barrett's oesophagus
Authors: Odze Robert , Frei Nicola , Khoshiwal Amir M , Duits Lucas C , Bergman Jacques , Stachler Matthew D 
Published: May 2023

AimsPatients with non‐dysplastic Barrett's oesophagus (BE) often show a wide range of ‘atypical’ histological features in the bases of the crypts. However, the significance of crypt atypia has never been evaluated, despite prior studies showing the presence of DNA content and other molecular abnormalities in this epithelium. The aim of this study was to evaluate whether the degree of crypt atypia in BE patients without dysplasia correlates with progression to high‐grade dysplasia/adenocarcinoma (HGD/EAC).Methods and resultsBaseline biopsies from 114 BE patients without dysplasia, 57 who progressed to HGD/EAC (progressors) and 57 who did not progress (non‐progressors), were included in the study. Biopsies were evaluated for the degree of basal crypt atypia on a three‐point scale according to discrete histological criteria. In non‐progressors, 64.9, 31.6 and 3.5% of biopsies had a crypt atypia score of 1, 2 and 3, respectively, with a mean score of 1.39 ± 0.56. The percentage of biopsies with an atypia score of 2 or 3 increased in progressors [42.1, 42.1 and 15.8% of biopsies scored 1, 2 or 3, respectively, with a mean score of 1.74 ± 0.72 (P = 0.004)]. The odds ratio of grade 3 crypt atypia for progression to HGD/EAC was 5.2 (95% confidence interval = 1.1–25.0, P = 0.04) and the findings did not change significantly when the data were analysed according to progression to either HGD or EAC.ConclusionsThis study shows that non‐dysplastic crypts in BE are biologically abnormal, suggesting that neoplastic progression begins prior to the onset of dysplasia. The degree of crypt atypia in BE patients without dysplasia correlates with progression.
Maritime inventory routing: recent trends and future directions
Authors: Fagerholt Kjetil , Hvattum Lars Magnus , Papageorgiou Dimitri J. , Urrutia Sebastián 
Published: May 2023

AbstractWe review recent literature pertaining to the maritime inventory routing problem (MIRP), a stimulating, albeit niche, subclass of vendor‐managed inventory problems. MIRPs deal with optimally distributing products with a (typically heterogeneous) vessel fleet between production and consumption ports with inventory tracking and inventory limits. We present two mixed‐integer linear programming models for the MIRP—one based on discrete time, the other based on continuous time—and we discuss the advantages and disadvantages of each of the two modeling approaches. In surveying more than 50 papers spanning the decade 2013–2023, we investigate MIRP variants from many different applications and discuss how these have been modeled and solved. Our purpose is to provide a comprehensive overview of state‐of‐the‐art MIRP research published in this period, collated along multiple dimensions. In addition to providing information about available test instances, we highlight recent trends and interesting avenues for future research. As such, we believe this survey will be useful to students, researchers, and practitioners in this domain.
Fifty years of operational research in forestry
Authors: Rönnqvist Mikael , Martell David , Weintraub Andres 
Published: May 2023

AbstractThis paper describes operational research (OR) contributions in forestry over the past 50 years, based on scientific pathways along which the authors have traveled. We draw on our personal experiences and recall how the use of OR in forestry has evolved from the early use of linear programming in the Canadian forest products industry in the 1950s and strategic forest management planning by the U.S. Forest Service in the 1960s. We describe the widespread use of OR in many aspects of forestry over a 50‐year timespan (1970–2020) and to the present day, where climate change and biodiversity challenges and increased data availability are important. The paper covers many areas of forestry, including forest management, natural disturbance processes, tactical and operational harvesting, transportation, and value chain management. Each section in the paper includes a historical description of OR‐based key applications as well as OR‐based model and method developments Additionally, we discuss our perceptions of OR in future use and its importance in forestry.
When do I feel good when I am nice? A diary study about the relationship between prosocial behavior and well‐being
Authors: Kesenheimer Jana S. , Kastenmüller Andreas , Kinkel Lea‐Sophie , Fidan Beril , Greitemeyer Tobias 
Published: May 2023

AbstractPrevious research has shown that prosocial behavior not only benefits the person being helped, but also promotes the well‐being of the person helping. Still, several specific characteristics of the helping situation have not yet been considered in one single study. Thus, we examined under which circumstances the helper's well‐being is more or less positively influenced. We carried out a 7‐day diary study with 363 participants who reported on their everyday prosocial behavior as well as their well‐being. We examined the effect of 13 potential moderation variables based on theoretical assumptions of self‐determination theory and theories about reciprocity and altruism, as well as invested resources. Overall, the results replicated the positive effect of prosocial behavior on well‐being. However, the helper's autonomy, the recipient's gratitude and low responsibility for the situation, the improvement of the situation through helping, and low expected self‐blame (when not helping) on the side of the helper were necessary conditions. Moreover, taking within‐subject effects into consideration, significant random effects in multilevel models showed that the effect of prosocial behavior on well‐being can highly differ from person to person, emphasizing that not all people under all circumstances are happier when they help others.
The mediating effect of sense of coherence in the relationship between eating attitudes and self‐esteem in adolescents
Authors: Günaydin Yurdagül , Uzdil Nurcan 
Published: May 2023

AbstractPurposeThis study aimed to examine the mediating effect of a sense of coherence (SOC) in the relationship between eating attitudes and self‐esteem in adolescents.MethodsThe study was conducted in a descriptive‐correlational exploratory design. The sample of the study consisted of 1175 adolescents who met the inclusion criteria. Data were obtained by the researchers using personal information form, the Sense of Coherence Scale (SOC‐13), the Eatıng Attitude Test (EAT‐26), and the Rosenberg Self‐Esteem Scale (RSES).ResultsSOC‐13 mean score was 50.21 ± 11.06, EAT‐26 mean score was 14.53 ± 10.17, and RSES mean score was 4.17 ± 1.66. It was found that there was a statistically significant negative relationship between the mean scores of RSES and the EAT, a positive relationship between the mean scores of the RSES and SOC, and a negative relationship between the mean scores of EAT and SOC. Moreover, the mediating role of SOC was found to be moderate. Furthermore, 4.5% of adolescents' SOC scores are explained by eating attitude. On the other hand, 16.4% of self‐esteem scores are explained by eating attitude and SOC.ConclusionAs a result of this study, it was determined that students' SOC moderately mediated the relationship between eating attitude and self‐esteem. At the same time, eating attitude had a direct predictive effect on self‐esteem.
Teaching Religion and Upholding Academic Freedom
Authors: Barre Betsy , Berkson Mark , Cates Diana Fritz , Clem Stewart , Ilesanmi Simeon O. , Lewis Thomas A. , Mathewes Charles , McCarty James , Oh Irene , Omer Atalia , Patton Laurie L. , Wheeler Kayla Renee 
Published: May 2023

ABSTRACTThe editors of the JRE collected short essays from scholars of religion in response to a recent incident at Hamline University that made national headlines. Last fall, Hamline University administrators refused to extend a contract to an adjunct professor of art history after a Muslim student accused her of Islamophobia for showing a 14th‐century image of Mohammad in an online class. The event provoked intense conversations about issues of academic freedom, religious diversity, the status of contingent faculty, and race. These essays bring together scholarly and personal reflections about the incident at Hamline and what it means for the pedagogy of religious studies.
Determinants of rapid adaptation in species with large variance in offspring production
Authors: Korfmann Kevin , Temple‐Boyer Marie , Sellinger Thibaut , Tellier Aurélien 
Published: May 2023

AbstractThe speed of population adaptation to changing biotic and abiotic environments is determined by the interaction between genetic drift, positive selection and linkage effects. Many marine species (fish, crustaceans), invertebrates and pathogens of humans and crops, exhibit sweepstakes reproduction characterized by the production of a very large amount of offspring (fecundity phase) from which only a small fraction may survive to the next generation (viability phase). Using stochastic simulations, we investigate whether the occurrence of sweepstakes reproduction affects the efficiency of a positively selected unlinked locus, and thus, the speed of adaptation since fecundity and/or viability have distinguishable consequences on mutation rate, probability and fixation time of advantageous alleles. We observe that the mean number of mutations at the next generation is always the function of the population size, but the variance increases with stronger sweepstakes reproduction when mutations occur in the parents. On the one hand, stronger sweepstakes reproduction magnifies the effect of genetic drift thus increasing the probability of fixation of neutral allele and decreasing that of selected alleles. On the other hand, the time to fixation of advantageous (as well as neutral) alleles is shortened by stronger sweepstakes reproduction. Importantly, fecundity and viability selection exhibit different probabilities and times to fixation of advantageous alleles under intermediate and weak sweepstakes reproduction. Finally, alleles under both strong fecundity and viability selection display a synergistic efficiency of selection. We conclude that measuring and modelling accurately fecundity and/or viability selection are crucial to predict the adaptive potential of species with sweepstakes reproduction.
Clones on the run: The genomics of a recently expanded partially clonal species
Authors: Pereyra Ricardo T. , Rafajlović Marina , De Wit Pierre , Pinder Matthew , Kinnby Alexandra , Töpel Mats , Johannesson Kerstin 
Published: May 2023

AbstractWhy species that in their core areas mainly reproduce sexually become enriched with clones in marginal populations (“geographic parthenogenesis”) remains unclear. Earlier hypotheses have emphasized that selection might promote clonality because it protects locally adapted genotypes. On the other hand, it also hampers recombination and adaptation to changing conditions. The aim of the present study was to investigate the early stages of range expansion in a partially clonal species and what drives an increase in cloning during such expansion. We used genome‐wide sequencing to investigate the origin and evolution of large clones formed in a macroalgal species (Fucus vesiculosus) during a recent expansion into the postglacial Baltic Sea. We found low but persistent clonality in core populations, while at range margins, large dominant clonal lineages had evolved repeatedly from different sexual populations. A range expansion model showed that even when asexual recruitment is less favourable than sexual recruitment in core populations, repeated bottlenecks at the expansion front can establish a genetically eroded clonal wave that spreads ahead of a sexual wave into the new area. Genetic variation decreases by drift following repeated bottlenecks at the expansion front. This results in the emerging clones having low expected heterozygosity, which corroborated our empirical observations. We conclude that Baker's Law (clones being favoured by uniparental reproductive assurance in new areas) can play an important role during range expansion in partially clonal species, resulting in a complex spatiotemporal mosaic of clonal and sexual lineages that might persist during thousands of generations.
Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011–2020
Authors: de Freitas Vera Lúcia Teixeira , Rocha Francisco Marcelo Monteiro , Ribeiro Emanoella Nogueira , Lindoso José Angelo Laulleta , Bittencourt Amanda Azevedo , Pivetta Dhara Nicole Araujo Greco , Benard Gil , de Freitas‐Xavier Roseli Santos 
Published: May 2023

AbstractBackgroundSporotrichosis is an endemic subcutaneous mycosis classically caused by the Sporothrix schenckii species complex. Recently, sporotrichosis has emerged in Brazil as a cat‐transmitted epidemic caused by a new species, Sporothrix brasiliensis.ObjectivesTo survey the clinical‐epidemiological profile of all sporotrichosis cases diagnosed between 2011 and 2020 at a reference hospital in São Paulo metropolitan area and evaluate the annual distribution of cases in relation to seasonality.MethodsPatients' demographic and clinical‐epidemiological data were surveyed. A generalized linear model was fitted to relate the quarterly number of sporotrichosis cases detected between 2015 and 2019 with precipitation and temperature series. Prediction of the number of cases from 2011 to 2014 was attempted based on the fitted model without the trend component that appears from 2015.ResultsAmong 271 suspected cases admitted during 2011–2020, 254 were confirmed by fungal isolation and/or clinical‐epidemiological criteria. We observed that 2015 onwards the number of cases regularly increased during Autumn and Winter, the driest and coldest stations of the year. We verified that temperature series affected the number of cases (p = .005) because an increase of 1°C in the temperature series was associated with a 14.24% decrease in the average cases number, with the average number of cases increasing by 10.96% (p < .0001) every quarter, corresponding to an annual increase of 52%. Between 2011 and 2014, the predicted number of sporotrichosis cases averaged 10–12 per year, with 33%–38% occurring in the winter.ConclusionWe hypothesize that sporotrichosis seasonality is associated with the felines' oestrus cycle, which may provide alternative, cat‐directed approaches to the sporotrichosis epidemic control.