bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11
Authors: Li Ling , Zhao Manzhi , van Meurs Marjan , Brouwers-Haspels Inge , den Dekker Renske J. H. , Wilmsen Merel E. P. , Grashof Dwin G. B. , van de Werken Harmen J. G. , Rao Shringar , Rokx Casper , Mueller Yvonne M. , Katsikis Peter D. 
Published: January 2025

IntroductionBryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. In HIV research, it has shown anti-HIV effects during acute infection and reactivation of latent HIV in chronic infection. As effective CD8+ T cell responses are essential for eliminating reactivated virus and achieving a cure, it is important to investigate how bryostatin-1 affects HIV-specific CD8+ T cells. HIV-specific CD8+ T cells often become exhausted, showing reduced proliferative potential and impaired cytokine production, a dysfunction also observed in cancer. Therefore, we further investigated how bryostatin-1 directly impacts exhausted CD8+ T cells.MethodsPBMCs from people with HIV (PWH) were treated with bryostatin-1 and tracked with proliferation dye for cell expansion. One day 6, HIV-specific CD8+ T cells were detected by tetramers staining and examined by flow cytometry. By utilizing an established in vitro murine T cell exhaustion system, changes in inhibitory receptors, transcription factors, cytokine production and killing capacity of bryostatin-1 treated exhausted CD8+ T cells were determined by flow cytometry. RNA-seq analysis was performed to study transcriptional changes in these cells.ResultsWe found that bryostatin-1 improved the expansion and decreased PD-1 expression of HIV-specific CD8+ T cells. Bryostatin-1 enhanced the functionality and proliferation while decreasing inhibitory receptor expression of in vitro generated exhausted CD8+ T cells. Bryostatin-1 upregulated TCF-1 and decreased TOX expression. These changes were confirmed through RNA-seq analysis. RNA-seq revealed that mitogen-activated protein kinases (MAPK) 11 was significantly downregulated in exhausted CD8+ T cells, however, it greatly upregulated after bryostatin-1 treatment. Inhibition of MAPK11 in bryostatin-1-treated cells blocked the increased proliferation and IFN-γ production induced by bryostatin-1, but did not affect other bryostatin-1 induced effects, such as the reduction of inhibitory receptors.DiscussionOur data demonstrate that bryostatin-1 induces a MAPK 11-dependent improvement in the proliferative and functional capacity of exhausted T cells. This study provides a rationale for bryostatin-1's potential to help eradicate the HIV reservoir during treatment, and it may also contribute to cancer immunotherapy by functionally improving exhausted CD8+ T cells.
Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions
Authors: Dåstøl Vilde Øverlien , Haftorn Kristine Løkås , Rudsari Hamid Khoshfekr , Jaholkowski Piotr Pawel , Størdal Ketil , Håberg Siri Eldevik , Weinberg Clarice R. , Rider Lisa G. , Andreassen Ole A. , Brantsæter Anne Lise , Caspersen Ida Henriette , Sanner Helga 
Published: January 2025

ObjectivesJuvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and gene-environment interactions.MethodsWe used the Norwegian Mother, Father, and Child Cohort Study (MoBa), a population-based prospective pregnancy cohort (1999–2008). JIA patients were identified through the Norwegian Patient Registry, with remaining mother-child pairs serving as controls. We assessed maternal seafood intake and dietary contaminants typically found in seafood using a food frequency questionnaire completed during pregnancy, mainly comparing high (≥90th percentile, P90) vs low (&lt;P90) intake. Multivariable logistic regression calculated adjusted odds ratios (aOR), including sex-stratification analyses. A polygenic risk score (PRS) for JIA was used in a subsample to assess gene-environment interactions.ResultsWe identified 217 JIA patients and 71,884 controls. High vs low maternal intake of lean/semi-oily fish was associated with JIA (aOR 1.51, 95% CI 1.02-2.22), especially among boys (aOR 2.13, 95% CI 1.21-3.75). A significant gene-environment interaction was observed between total fish intake and PRS, with high fish intake associated with JIA primarily in those with low PRS (p&lt;0.03). We found no associations between high vs low exposure to other types of seafood or environmental contaminants and JIA.ConclusionsWe found a modestly increased risk of JIA associated with high intake of lean/semi-oily fish during pregnancy, not explained by estimated exposure to dietary contaminants. Our data suggest a more pronounced association in children with a lower genetic predisposition for JIA.
Insights into the salt levels in bread offers in Slovenia: trends and differences
Authors: Kugler Saša , Hristov Hristo , Blaznik Urška , Hribar Maša , Hafner Edvina , Kušar Anita , Pravst Igor 
Published: January 2025

ObjectiveBakery products are considered as one of main dietary sources of sodium/salt in Slovenia. Our main objective was to assess the salt content in bread in Slovenia, focusing into different bread categories and sales channels. The data collected in 2022 was compared with year 2012.MethodsA follow-up study on salt content of bread sold in Slovenia was conducted. Bread samples were purchased in large retail shops and smaller bakeries across 11 statistical regions of Slovenia. Sodium content was determined by inductively coupled plasma mass spectrometry; salt content was calculated by multiplying sodium content with 2.54, assuming all sodium corresponds to sodium chloride.ResultsIn 2022, 178 bread samples were purchased and analyzed. Weighted mean salt content in bread was 1.35 (95% CI 1.28–1.42) g/100 g in 2012, and 1.26 (95% CI 1.22–1.29) g/100 g in 2022, showing a 7% decrease. Notable differences in the salt content were observed between various bread subcategories and retail environments. In addition, a significant difference was observed between white wheat bread sold in large retail shops and smaller bakeries, where a higher salt content was observed.ConclusionWhile study results show small decrease in the salt content in bread in Slovenia in last decade, the salt reduction targets set by the WHO have not been met. Additional efforts are needed to stimulate bread reformulation with reducing salt content.
Mediation of endothelial activation and stress index in the association between vitamin B6 turnover rate and diabetic retinopathy: an analysis of the National Health and Nutrition Examination Survey
Authors: Yin Jie , Chen Juan , Chen Yuanyuan 
Published: January 2025

AimThis study aimed to explore the association between the ratio of 4-pyridoxine (4-PA) to pyridoxal 5′-phosphate (PLP) (4-PA/PLP) and diabetic retinopathy (DR) and further assess the mediating effect of Endothelial Activation and Stress Index (EASIX) on the association between 4-PA/PLP and DR.MethodsIn this cross-sectional study, 1,698 patients with diabetes from the National Health and Nutrition Examination Survey were included. According to the median, 4-PA/PLP was categorized into a high-level group (≥0.89) and a low-level group (&lt;0.89). As the EASIX had a skewed distribution, it was log-transformed before analysis. Weighted logistic regression models were used to investigate the association of 4-PA/PLP with EASIX and DR and the mediating effect of EASIX on the association between 4-PA/PLP and DR. The distribution-of-product method was adopted to assess the mediating effect. Subgroup analysis was performed based on the age and duration of diabetes.ResultsA total of 362 diabetic patients were classified as having DR. After adjusting for all covariates, a higher level of 4-PA/PLP was associated with an increased level of log EASIX [odds ratio (OR) = 1.56, 95% confidence interval (CI): 1.06–2.30]. A higher ratio of 4-PA/PLP was associated with increased odds of DR compared to the reference group with lower levels of 4-PA/PLP (OR = 1.94, 95%CI: 1.40–2.67). In addition, we found that log EASIX may play a mediating role in the 4-PA/PLP and DR, with a 95% CI of distribution of product of 0.31 (95% CI: 0.02–0.67). The proportion of mediation was 69.06%. The mediating effect of log EASIX was also observed in individuals with diabetes who were aged≥60 years (proportion of mediation: 50.63%) or had a duration of diabetes ≥10 years (proportion of mediation: 71.83%).ConclusionThis study found a positive association between high levels of 4-PA/PLP and an increased risk of DR, with the relationship being partially mediated by log EASIX.
Anxiety, depression, and their association with unintentional injury risk among older adult populations in Guangxi, China: a cross-sectional study
Authors: Niu Li , Zhang Jie , Lu Chun-liu , Zhang Yong , Mo Xin-xin , Xu Rong , Luo Hong-ye 
Published: January 2025

BackgroundThe aging population presents a significant public health challenge, particularly concerning mental health and injury prevention. Anxiety and depression are common among the older adult, affecting their quality of life and increasing the risk of unintentional injuries (UI). This study aims to explore the association between anxiety and depression and UI risk among the older adult in Guangxi, China, using data from the 2023 National Health Service Survey.MethodsA cross-sectional design was employed, analyzing data from 2,894 participants aged 60 and above in Guangxi. The primary variables were anxiety and depression, assessed via validated scales, with UI as the dependent variable. Logistic regression was used to estimate crude and adjusted odds ratios (OR) with 95% confidence intervals (CI), adjusting for potential confounders such as age, gender, socioeconomic status, and lifestyle factors.ResultsSignificant findings indicate that individuals with anxiety and depression had nearly double the risk of UI compared to those without these conditions (adj. OR = 1.92, 95% CI: 1.42–2.6, p &lt; 0.001). Alcohol consumption was also associated with higher UI risk (adj. OR = 1.46, 95% CI: 1.05–2.03, p = 0.023). Females had a significantly higher adjusted odds of UI compared to males (adj. OR = 1.38, 95% CI: 1.03–1.84, p = 0.029), and rural residents were more likely to experience UI than urban dwellers (adj. OR = 1.38, 95% CI: 1.05–1.82, p = 0.02). Exercise frequency was inversely related to UI risk, with those exercising 1–2 times per week having reduced odds (adj. OR = 0.46, 95% CI: 0.22–0.98, p = 0.044). Other factors such as age, marital status, hypertension, diabetes, and main caregiver showed no significant associations with UI.ConclusionAddressing mental health issues and promoting moderate exercise may help reduce UI risk in the older adult. Policies should focus on enhancing mental health services and injury prevention programs, particularly in rural settings, to improve the overall health and safety of the aging population in Guangxi.
A Data-Driven Deep Learning Framework for Prediction of Traffic Crashes at Road Intersections
Authors: Wang Mengxiang , Lee Wang-Chien , Liu Na , Fu Qiang , Wan Fujun , Yu Ge 
Published: January 2025

Traffic crash prediction (TCP) is a fundamental problem for intelligent transportation systems in smart cities. Improving the accuracy of traffic crash prediction is important for road safety and effective traffic management. Owing to recent advances in artificial neural networks, several new deep-learning models have been proposed for TCP. However, these works mainly focus on accidents in regions, which are typically pre-determined using a grid map. We argue that TCP for roads, especially for crashes at or near road intersections which account for more than 50% of the fatal or injury crashes based on the Federal Highway Administration, has a significant practical and research value and thus deserves more research. In this paper, we formulate TCP at Road Intersections as a classification problem and propose a three-phase data-driven deep learning model, called Road Intersection Traffic Crash Prediction (RoadInTCP), to predict traffic crashes at intersections by exploiting publicly available heterogeneous big data. In Phase I we extract discriminative latent features called topological-relational features (tr-features), of intersections using a neural network model by exploiting topological information of the road network and various relationships amongst nearby intersections. In Phase II, in addition to tr-features which capture some inherent properties of the road network, we also explore additional thematic information in terms of environmental, traffic, weather, risk, and calendar features associated with intersections. In order to incorporate the potential correlation in nearby intersections, we utilize a Graph Convolution Network (GCN) to aggregate features from neighboring intersections based on a message-passing paradigm for TCP. While Phase II serves well as a TCP model, we further explore the signals embedded in the sequential feature changes over time for TCP in Phase III, by exploring RNN or 1DCNN which have known success on sequential data. Additionally, to address the serious issues of imbalanced classes in TCP and large-scale heterogeneous big data, we propose an effective data sampling approach in data preparation to facilitate model training. We evaluate the proposed RoadInTCP model via extensive experiments on a real-world New York City traffic dataset. The experimental results show that the proposed RoadInTCP robustly outperforms existing methods.
Les probabilités, la Belgique et l’Église. Paul Mansion, serviteur de la science et de la foi
Authors: Mazliak Laurent 
Published: January 2025

Probability, Belgium and the Church : Paul Mansion, at the service of science and faith.
This article examines the reasons that led the Belgian mathematician Paul Mansion to take an interest in the calculus of probability. Not only did the probabilities have a particularly favorable academic situation in Belgium, but for Mansion, a militant Catholic, a probabilistic approach to certain scientific questions, especially the questions of evolution, proved very valuable in responding to the « modernist crisis » that passed through the Roman Church of his time. We look more specifically at a memoir published by Mansion in 1903 and at some links with the Institut de philosophie de Louvain and its founder Désiré Mercier.
2009-2019 : dix ans de publications sur l’enseignement de la statistique en France
Authors: Rolland Antoine 
Published: January 2025

2009-2019 : Ten years of publications on statistics education in France.
The Statistique et Enseignement journal was published by the Société Française de Statistique [SFdS] between 2010 and 2018. Its publication was ceased, which is an opportunity to conduct a state of the art of the publications in the field of statistics education in France during the same period. We approximately found 160 communications in this field, in various forms (PhD dissertations or articles in journals run by societies and institutions like SFdS, IREM, APMEP). Most of these communications are dedicated to theoretical explanations of concepts, share educative materials, or provide feedbacks on the evolutions of statistics curricula at the high-school level. But just a few are dedicated to theoretical considerations on statistics education itself. Both quantitative and qualitative analyses are conducted ; they show that much work is needed in statistics education to identify the difficulties faced by students, especially in statistics and data science curricula at the university level.
Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament–Bone Junction Repair
Authors: Chen Kaiting , Liu Zezheng , Zhou Xinying , Zheng Wanyu , Cao He , Yang Zijian , Wang Zhengao , Ning Chengyun , Li Qingchu , Zhao Huiyu 
Published: January 2025

Tendon/ligament–bone junctions (T/LBJs) are susceptible to damage during exercise, resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate hierarchical structure hinders self-regeneration. Multiphasic strategies have been explored to fuel heterogeneous tissue regeneration and integration. This review summarizes current multiphasic approaches for rejuvenating functional gradients in T/LBJ healing. Synthetic, natural, and organism-derived materials are available for in vivo validation. Both discrete and gradient layouts serve as sources of inspiration for organizing specific cues, based on the theories of biomaterial topology, biochemistry, mechanobiology, and in situ delivery therapy, which form interconnected network within the design. Novel engineering can be constructed by electrospinning, 3-dimensional printing, bioprinting, textiling, and other techniques. Despite these efforts being limited at present stage, multiphasic scaffolds show great potential for precise reproduction of native T/LBJs and offer promising solutions for clinical dilemmas.
ОРНИТОФАУНА ИЖЕВСКОГО ВОДОХРАНИЛИЩА
Authors: Меньшиков Александр Григорьевич , Князева Галина Юрьевна 
Published: January 2025

Проведен анализ современного состояния орнитофауны Ижевского водохранилища и её динамика, по данным полевых исследований 2023-2024 гг. Дана количественная характеристика плотности населения птиц на различных биотопических участках территории в различные сезоны года, представлен аннотированный список птиц акватории и водоохраной зоны водохранилища.
The current state of the Izhevsk reservoir’s avifauna and its dynamics was analyzed. According to field studies, conducted in 2023-2024, we gives a quantitative characteristic of the density of the population of birds in various biotops of the territory in different seasons of the year. An annotated list of birds of the water area and the water protection zone of reservoir is presented.
ТЕНДЕНЦИЯ ИЗМЕНЕНИЯ АГРОКЛИМАТИЧЕСКИХ ПОКАЗАТЕЛЕЙ НА ТЕРРИТОРИИ ЧУВАШСКОЙ РЕСПУБЛИКИ В ПОСЛЕДНИЕ ДЕСЯТИЛЕТИЯ
Authors: Китарьева Марина Анатольевна 
Published: January 2025

В данной статье рассматриваются изменения агроклиматических показателей на территории Чувашской Республики за период 1961-2023 гг. с использованием ежедневных данных метеорологических наблюдений 5-ти станций. Рассчитаны следующие характеристики: даты устойчивого перехода среднесуточной температуры воздуха через 5 и 10 °С весной и осенью, продолжительность периода вегетации и активной вегетации, суммы активных и эффективных температур, количество выпавших осадков за период активной вегетации, гидротермический коэффициент (ГТК) Селянинова, индекс сухости (ИС) Будыко, биологическая эффективность климата. Дана оценка биологической эффективности климата Чувашской Республики. Выполненные расчёты показали, что продолжительность вегетации увеличивается, в связи с этим увеличиваются суммы активных и эффективных температур. Выявлена тенденция слабого роста засушливости климата в республике за период исследования.
This article examines the changes in agro-climatic indicators on the territory of the Chuvash Republic for the period 1961-2023 using daily meteorological observations from 5 stations. The following characteristics were calculated: the dates of the steady transition of the average daily air temperature through 5 and 10 °C in spring and autumn, the duration of the growing season and active vegetation, the sum of active and effective temperatures, the amount of precipitation during the active growing season, Selyaninov hydrothermal coefficient (GTC), Budyko dryness index (IS), biological climate efficiency. Keywords: average daily air temperature, growing season, active vegetation period, sum of active temperatures, sum of effective temperatures, hydrothermal coefficient, dryness index. The assessment of the biological efficiency of the climate of the Chuvash Republic is given. The calculations performed showed that the duration of vegetation increases, and therefore the sums of active and effective temperatures increase. The trend of a weak increase in the aridity of the climate in the republic during the study period has been revealed.
Optimizing photochromic reactions of hydrophobic copper-doped zinc sulfide nanocrystals
Authors: Kimura Mayu , Yoshioka Daisuke , Matsuhiro Kaori , Kobayashi Yoichi 
Published: January 2025

Abstract
Copper-doped zinc sulfide nanocrystals (Cu-ZnS NCs) exhibit durable, temperature-stable photochromic properties with cost-effective synthesis. However, existing photochromic Cu-ZnS NCs are water-soluble, limiting industrial applications. Here, we synthesized hydrophobic Cu-ZnS NCs using ligands compatible with organic solvents. These NCs display reversible photochromism in several organic solvents, changing from pale yellow to brown under 365 nm light and reverting within tens of minutes. We systematically examined the effects of zinc precursors, particle size, Cu doping concentration, and solvents to optimize the performance and elucidate an optimal coloration condition. This study demonstrates the promise of Cu-ZnS NCs as versatile, next-generation photochromic materials.
Analisis Penerapan Good Government Governance pada Pengelolaan Anggaran Pendapatan dan Belanja Desa (Studi Kasus pada Desa Pematang Johar, Kabupaten Deli Serdang)
Authors: Aldiansyah Ferdy , Wirananda Henny Andriyani 
Published: January 2025

This study aims to analyze the application of good government governance principles in the management of APBDes in Pematang Johar Village, Deli Serdang Regency starting from the planning, implementation, administration, as well as reporting and accountability stages. Researchers take three principles of good government governance which are used as variable indicators, including transparency, participation and accountability. The subjects in this study include the Chairman / Member of BPD, Village Head, Village Secretary and Treasurer, and community leaders of Pematang Johar Village. Research design is a guideline or procedure and technique in research planning that is useful as a guide for building strategies that produce research models. The research design conducted in this study is a qualitative method. Data collection techniques in this study used observation, interview and documentation methods. The data analysis method used in this study is qualitative descriptive analysis. The result of this study is that the management of APBDes in Pematang Johar Village, Deli Serdang Regency is broadly in accordance with the principles of good government governance, namely transparency, participation and accountability.
EKSTRAK BAWANG PUTIH (Allium sativum L) SEBAGAI ZAT AKTIF PADA FORMULASI SEDIAAN GEL
Authors: Sopianti Densi Selpia , Bulan Putri Serindang 
Published: January 2025

Bawang putih (Allium sativum L) memiliki julukan sebagai antibiotik alami. Aplikasi bawang putih pada wajah juga mempunyai beberapa manfaat yang bisa menyembuhkan jerawat (acne vulgaris). Tujuan penelitian ini membuat sediaan sediaan gel sebagai zat aktif yang digunakan yaitu ekstrak bawang putih (Allium sativum L). Metode dalam penelitian experimental laboratorium, dimana bawang putih sebagai bahan aktif diekstrak dengan menggunakan metode maserasi. Dibuat 3 variasi formula sediaan yaituÃƒâ€šÃ‚Â 3%, 5%, dan 7% dan zat tambahan lain dalam sediaan gel menggunakan bahan Na.CMC, nipagin dan nipasol, gliserol dan olium guajava. Masing-masing formula gel dilakukan evaluasi sediaan meliputi organoleptis, homogenitas, uji pH, uji daya sebar, dan uji iritasi. Hasil evaluasi sifat fisik gel dari ketiga formula dengan variasi ekstrak bawang putih pada konsentrasi yang berbeda dihasilkan formula I dengan konsentrasi ekstrak bawang putih 3% menghasilkan uji yang lebih baik dibandingkan Formila II dan formula III.