bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dental Disorders Reported to the FDA Adverse Event Reporting System in
Association with Buprenorphine: An Analysis by Ingredient Composition
and Route of Administration
Authors: Woods Richard H. 
Published: August 2023

Background:
Background: Prior research has suggested buprenorphine-containing medications may
be associated with an increased risk of dental disorders. However, published data describing adverse
dental reactions in buprenorphine users by active ingredient composition and route of
administration are limited.

Objective:
The purpose of this study was to evaluate the influence of formulation on spontaneous
reporting of dental disorders among patients treated with buprenorphine.

Methods:
Adverse event reports submitted to the United States Food and Drug Administration Adverse
Event Reporting System (FAERS) between 2015 and 2022 were analyzed. Reporting odds
ratios (ROR) and 95% confidence intervals (CI) were calculated to measure disproportionality of
dental disorder reporting as classified by 39 Medical Dictionary for Regulatory Activities preferred
terms.

Results:
Compared to pooled reports for all other drugs across FAERS, both buprenorphine monotherapy
(ROR 3.09; 95% CI 2.61-3.66) and combination buprenorphine/naloxone (ROR 14.61;
95% CI 13.34-16.01) were associated with positive disproportionality signals. Signals of disproportionate
dental disorder reporting were also detected for buprenorphine medicines administered
by sublingual (ROR 20.03; 95% CI 18.04-22.24), buccal (ROR 4.46; 95% CI 3.00-6.61) and oral
(ROR 7.17; 95% CI 5.03-10.22) routes, but not for other modalities. In considering active ingredient
and route together, sublingual buprenorphine monotherapies (ROR 23.55; 95% CI 17.84-31.11)
and sublingual buprenorphine/naloxone (ROR 19.47; 95% CI 17.39-21.80) were each associated
with disproportionate reporting of dental disorders.

Conclusion:
Subject to the limitations of spontaneous adverse event data, this study identified significantly
disproportionate reporting of dental disorders to FAERS among patients treated with buprenorphine-
containing medications, including formulations administered by sublingual, buccal
and oral routes. These findings are consistent with prior data and suggest that regular oral care and
proper dental hygiene be emphasized for patients undergoing therapy with orally dissolving
buprenorphine.
The Reconstitution of T-cells after Allogeneic Hematopoietic Stem Cell
Transplant in a Pediatric Patient with Congenital Amegakaryocytic
Thrombocytopenia (CAMT)
Authors: Bayegi Shideh Namazi , Hamidieh Amir Ali , Behfar Maryam , Saghazadeh Amene , Bozorgmehr Mahmood , Tajik Nader , Delbandi Ali-Akbar , Delavari Samaneh , Shekarabi Mehdi , Rezaei Nima 
Published: August 2023

Background:
Congenital amegakaryocytic thrombocytopenia (CAMT) is a bone marrow failure syndrome with autosomal recessive inheritance characterized by the lack of megakaryocytes and thrombo-cytopenia. The cause of the disease is a mutation in the c-Mpl gene, which encodes the thrombopoietin (TPO) receptor. The main treatment for this genetic disorder is an allogeneic hematopoietic stem cell trans-plant (allo-HSCT). However, transplant-related mortality, development of acute and chronic graft-versus-host disease (GvHD), and susceptibility to opportunistic infections are major barriers to transplantation. Delay in the reconstitution of T cells and imbalance in the regeneration of distinct functional CD4 and CD8 T-cell subsets mainly affect post-transplant complications. We report a case of CAMT, who developed acute GvHD but had no signs and symptoms of chronic GvHD following allo-HSCT.

Case Presentation:
At the age of four, she presented with petechiae and purpura. In laboratory investiga-tions, pancytopenia without organomegaly, and cellularity less than 5% in bone marrow biopsy, were ob-served. A primary diagnosis of idiopathic aplastic anemia was made, and she was treated with prednisolone, cyclosporine, and anti-thymocyte globulin (ATG), which did not respond. Genetic analysis revealed the mutation c.1481T>G (p. L494W) in exon 10 of the c-Mpl gene, and the diagnosis of CAMT was confirmed. The patient underwent allo-HSCT from a healthy sibling donor. Alloimmunization reactions and immune disorders were present due to long-term treatment with immunosuppressive medications and repeated blood and platelet transfusions. Hence, the regeneration of T-lymphocytes after allo-HSCT was evaluated.

Conclusion:
Successful treatment of acute GvHD prevented advancing the condition to chronic GvHD, and this was accompanied by delayed T-cell reconstitution through an increase in Treg:Tcons ratio.
Pustakawan dan Perannya dalam Mendukung Kesehatan Mental di Era New Normal
Authors: Zuraida Shinta Sisca 
Published: August 2023

Pandemi covid-19 yang merebak sejak hampir dua tahun yang lalu telah mengubah tatanan kehidupan dari berbagai lini, mulai dari sosial, ekonomi, budaya, pendidikan dan lainnya. Hal ini memunculkan masalah baru tentang kesehatan yaitu masalah kesehatan jiwa. Di Indonesia, berdasarkan Data Riskesdas tahun 2007, diketahui bahwa prevalensi gangguan mental emosional seperti gangguan kecemasan dan depresi sebesar 11,6% dari populasi orang dewasa. Berarti dengan jumlah populasi orang dewasa Indonesia lebih kurang 150.000.000 ada 1.740.000 orang saat ini mengalami gangguan mental emosional (Depkes, 2007).Adanya kebijakan baru juga telah mengubah pola layanan di perpustakaan. Hal tersebut menjadi suatu tantangan tersendiri bagi lembaga pengelola informasi seperti perpustakaan dan bagi pustakawan selaku pengelola informasi. Pustakawan harus terus meningkatkan pengetahuan dan keterampilan sebagai bentuk adaptasi terhadap berbagai perubahan dan perkembangan tersebut. Pustakawan dituntut untuk memiliki beberapa keahlian kompetensi dan menjalankan fungsinya. Fungsi tersebut antara lain Pustakawan sebagai Information Manager, terdiri dari pustakawan sebagai gerbang manajemen perpustakaan konvensional dan modern, pustakawan sebagai manajer ilmu pengetahuan/informasi, pustakawan sebagai penerbit, pustakawan sebagai pengorganisasi jaringan sumber informasi, pustakawan sebagai penilai kebijakan pengembangan informasi, pustakawan sebagai penyaring sumber informasi. Fungsi kedua, Pustakawan sebagai Team Work terdiri pustakawan sebagai partner masyarakat, pustakawan sebagai tim desain, pustakawan sebagai kolaborator penyedia sumber daya teknologi. Fungsi ketiga, Pustakawan Sebagai terdiri dari pustakawan sebagai guru dan , pustakawan sebagai peneliti. Fungsi keempat, Pustakawan sebagai teknisi. Tulisan ini bertujuan untuk mengulas bagaimana pustakawan berperan dalam mendukung kesehatan mental di era tatanan baru new normal khususnya di perguruan tinggi.
Kata kunci: peran pustakawan, kesehatan mental, , perpustakaan perguruan tinggi
Conductas sexuales de riesgo relacionadas con las infecciones de transmisión sexual en una comunidad shuar de Taisha, Ecuador
Authors: Jiménez Brito Doriz , Sanhueza-Alvarado Olivia 
Published: August 2023

Objetivo: Describir conductas sexuales de riesgo relacionadas con las infecciones de transmisión sexual (ITS) en una comunidad shuar de Taisha, Ecuador. Metodología: Estudio descriptivo-transversal, con base en la teoría transcultural de Leininger. Participaron 215 adultos de ambos sexos, mayores de 18 años. Se utilizó un cuestionario validado por expertos, con método Delphi. El análisis relacional usó la prueba de X 2. Resultados: De la muestra, 153 mujeres y 62 hombres, el 99.1 % se identificó como heterosexual; 79.1 % indicó que su actividad sexual se inició en la preadolescencia, siendo lo más frecuente de tipo genital; 16.3 % reveló haber presentado alguna vez una ITS; 29.3 % ha tenido relaciones sexuales bajo efecto del alcohol o sustancias afrodisíacas, de los que 6 % indicó utilizar preservativo. El 60 % respondió que no lo usa porque no sabe cómo y por sentir menos placer; 36.7 % refirió tener relaciones sexuales fortuitas y, en ellas, 73 % sin usar preservativo. No hubo asociación significativa entre las conductas sexuales y la edad de las personas. Conclusión: El escaso uso de preservativo, relaciones sexuales fortuitas sin protección, inicio temprano y actividad sexual bajo efecto alcohol o sustancias afrodisíacas resultaron ser prácticas de riesgo para contraer una infección de transmisión sexual en esta comunidad indígena. Se necesita tender puentes, desde el sistema de salud hasta las comunidades, para implementar programas de prevención, diagnóstico y tratamiento en estadios tempranos para detección, educación, apoyo y control. El modelo de enfermería transcultural y el trabajo interdisciplinario permiten conocer los principios, valores y cosmovisión de los integrantes de la comunidad.
Penguatan Hukum Ekonomi Syariah pada Lembaga Keuangan Berdasarkan UU Nomor 21 Tahun 2011 tentang Otoritas Jasa Keuangan
Authors: Tegar Wahyudi  , Adik Sukmawati  , Ulfah Dwi Rahmawati  , Fahmi Fairuzzaman  
Published: August 2023

There are three objectives in this research, namely to find out the concept of sharia economic law in financial institutions in terms of Law Number 21 of 2011 concerning OJK (Financial Services Authority), strengthening sharia economic law within the Financial Services Authority, and handling sharia economic law problems. by the Financial Services Authority. In this study through the stages of problem identification, preparation of activity proposals, and program implementation. By using a normative legal research method (juridical-normative) with a statutory approach and a concept approach. In terms of data collection, library research is the technique used in collecting our research data for content analysis in order to obtain normative data. The concept of sharia economic law at the Financial Services Authority is related to sharia economics, the strengthening of sharia economic law is contained in Law Number 21 of 2011 concerning the Financial Services Authority, if there are sharia banking problems this can be resolved by using a court or through an institution organized by the Authority. Financial Services, namely Alternative Dispute Resolution Institutions.
Whistleblowing Research: Experimental Method Choices from Accounting and Management
Authors: Dias Maragno Lucas Martins , Skousen Christopher J. , Borba José Alonso 
Published: August 2023

ABSTRACTThis paper reviews whistleblowing experimental research in accounting and management and provides methodological guidance to new scholars. Based on a sample of 49 experimental papers, we summarized key issues, such as research design, task, dependent variable, and subject selection. Overall, we find that journals classified as accounting are more concentrated in experimental research and management journals are more diverse in terms of methodologies. Thus, whistleblowing experimental research from both areas is largely characterized by vignette-based studies. Accounting articles focused primarily on misappropriation of assets and fraudulent financial reporting, whereas management articles focused more broadly on unethical behavior. Also, some articles controlled for social desirability bias on the dependent variable. Finally, there is a predominance of the use of M.B.A. and postgraduate students in accounting studies and undergraduate studies in management. This paper is intended to further our understanding of experimental design choices and facilitate future research in this emerging field.
A Qualitative Review of Fraud Surrounding COVID-19 Relief Programs
Authors: Festa Mackenzie M. , Jones Megan M. , Knotts Kevin G. 
Published: August 2023

ABSTRACT
In this paper, we profile coronavirus disease 2019 (COVID-19) relief program frauds and agencies tasked with investigating those related crimes. Using a unique dataset of Department of Justice (DOJ) press releases from March 2020 to February 2022 relating to the Coronavirus Aid, Relief, and Economic Securities (CARES) Act, we qualitatively examine characteristics (e.g., wrongdoing, perpetrators, organizations affected, and collusions versus single actors) of approximately $2.6 billion of alleged fraud across the various relief programs. The most egregious fraud cases involved the abuse of the Paycheck Protection Program (PPP) and/or multiple CARES Act relief programs. Although there is some collusive fraud, most cases list only a single defendant. Lastly, we provide evidence suggesting a high degree of collaboration across agencies in the investigative process. These results also can help practitioners and academics better understand fraudulent activities of federal programs.
Data Availability: The data are available from the authors.
Goodwill Impairment after M&A: Acquisition-Level Evidence
Authors: Potepa James , Thomas Jacob 
Published: August 2023

ABSTRACT
To provide a fuller picture of compliance with ASC 350-20, we hand-collect data to track 893 large acquisitions across time. Our model, which links impairments to post-acquisition accounting and market performance declines as well as acquisition-year attributes, identifies 349 acquisitions as likely to impair. We provide evidence that 65 percent of these at-risk acquisitions impair in the next two years. Our study should be useful to future research as it clarifies the role of hand-collection, market to book ratios, segment-level data, and volatility. We also offer descriptive evidence on impairment patterns. Overall, we find high levels of compliance and little opportunism.
Pengaruh Ekstrak Daun Senduduk Bulu (Clidemia hirta L.) terhadap Perkecambahan dan Pertumbuhan Gulma (Praxelis clematidea)
Authors: Lestari Andriani Dwi , Pujisiswanto Hidayat , Susanto Herry , Sriyani Nanik 
Published: August 2023

Weeds are plants whose existence is not expected by farmers because they interfere with cultivated plants. But there are weeds that can produce phenolic compounds such as Clidemia hirta L which can be used as bioherbicides. This study aims to determine the effect of Clidemia hirta L. leaf extract on the germination and growth of Praxelis clematidea weeds. The research was carried out from June 2021 to September 2021 at the Weed Science Laboratory and Integrated Field Laboratory, Faculty of Agriculture, University of Lampung. This study used a completely randomized design (CRD) method with 6 treatments with concentrations of Clidemia hirta L leaf extract, namely 0; 1.5; 3.0; 4.5; 6.0; and 7.5%. Each treatment was repeated 6 times to obtain 72 experimental units. The observed variables are germination, crown height, root length, dry weight, and weed poisoning level. The data obtained were analyzed by analysis of variance and continued with the Least Significant Difference Test (LSD) at the 5% level. The results showed that the germination of Praxelis clematidea weed was significantly inhibited by the treatment of Clidemia hirta L leaf extract with a concentration of 1.5; 3.0; 4.5; 6.0; and 7.5%. While concentrations of 3.0%, 4.5%, 6.0%, and 7.5% Clidemia hirta L. leaf extract inhibited the growth of Praxelis clematidea weeds in the greenhouse. Key words: Clidemia hirta L., extract, Praxelis clematidea, germination, growth
Pengaruh Lama Perendaman Benih dalam Larutan CaCO3 terhadap Pertumbuhan Bibit Kakao (Theobroma cacao L.) pada Media Tanaman yang Berbeda
Authors: Ericson Gaol Uli Lumban , Sugiatno Sugiatno , Edy Akari , Susanto Herry 
Published: August 2023

The presence of pulp in cocoa seeds is known to inhibit seed germination and seedling growth. The conventional method of removing pulp from cocoa seeds is done mechanically by rubbing the seeds with rubbing ash. Conventional pulp removal has disadvantages, such as being less practical and potentially damaging the seed surface. Therefore, it is necessary to try chemically removing the pulp from cocoa seeds by soaking the seeds in a lime solution (CaCO3). This study aims to determine the effect of the duration of cocoa seed soaking in CaCO3 solution and different planting media compositions on seedling growth. The research was conducted from September to December 2021 at a plastic house in Labuhan Dalam Village, Tanjung Senang District, Bandar Lampung, and the Seed Laboratory, Faculty of Agriculture, University of Lampung, Gedong Meneng, Bandar Lampung. The study used a Completely Randomized Design (CRD) arranged in a factorial manner. The first factor was the duration of cocoa seed soaking in CaCO3 solution, consisting of no soaking, soaking for 30, 60, 120, and 240 minutes. The second factor was the planting media composition, consisting of a mixture of rice husk charcoal + manure, sand + manure, and sand + rice husk charcoal + manure. Each treatment combination was replicated three times, resulting in 45 experimental units. The observation data were analyzed using analysis of variance, and the mean differences were tested using the Least Significant Difference (LSD) test at the 5% level. The results of the study showed that the duration of cocoa seed soaking in CaCO3 solution had no effect on cocoa seedling growth. The planting media composition of sand + rice husk charcoal + manure had a significant effect on the best cocoa seedling growth compared to the planting media compositions of rice husk charcoal + manure and sand + manure. Soaking cocoa seeds in CaCO3 solution had no effect on cocoa seedling growth in different planting media. Keywords : Cocoa seeds, pulp, CaCO3, soaking, planting media
Optimasi Konsentrasi Paklobutrazol untuk Respons Pembungaan Tanaman Jambu Biji 'Kristal'
Authors: Yutamimah Siti Sarah , Widyatuti R. A. Diana , Utomo Setyo Dwi , Ginting Yohannes Cahya 
Published: August 2023

The advantages of 'Crystal' guava in Indonesia provide opportunities for farmers to cultivate and increase their production. Various methods of cultivation have been developed to increase the production of 'Crystal' guava, one of which is the use of Growth Regulators. Paclobutrazol is a plant PGR that regulates flowering outside the harvest season so that the production of 'Crystal' guava fruit can be maintained. The purpose of this study was to determine the best concentration of the effect of Paclobutrazol treatment in increasing the flowering of 'Crystal' guava plants. The research was conducted from August 2021 to March 2022 in Rajabasa Lama 1 Village, Labuhan Ratu District, East Lampung Regency. The treatment was carried out in a factorial manner using a single factor randomized block design with three replications so that 36 experimental units were obtained. The first factor was Paclobutrazol (A) which consisted of 6 treatment levels, there are A1 (0 ppm), A2 (4000 ppm), A3 (6000 ppm), A4 (8000 ppm), A5 (10,000 ppm), A6 (12,000 ppm). Paclobutrazol treatment with a concentration of 10,000 ppm gave the best results on the variables of flower number, number of ovules, number of harvested fruit and weight of harvested fruit. Keywords : Paclobutrazol, Concentration, ‘Crystal’ Guava Plants
Pengembangan Media Pembelajaran Visual Berbasis Aplikasi Canva untuk Meningkatkan Minat Belajar Siswa pada Mata Pelajaran Geografi
Authors: Dea Dea Irwanita , Nefilinda Nefilinda , Putri Rozana Eka 
Published: August 2023

Penelitian ini mempunyai tujuan untuk mengetahui dan menganalisis tentang pengembangan, kelayakan serta praktikalitas media pembelajaran berbasis canva pada mata pembelajaran geografi di kelas X IPS SMAN 2 Dayun, Kabupaten Siak. Metode yang digunakan dalam penelitian ini adalah penelitian dan pengembangan 4D (Four-D Models) meliputi 4 tahap yaitu : Define (pendefinisian), Design (perancangan), Development (penyebaran). Hasil penelitian ini adalah : (1) Pengembangan media pembelajaran berbasis canva dilakukan pengujian media oleh para ahli yaitu terdiri dari para ahli pendidikan, ahli media, ahli bahasa, ahli IT, kemudian dilakukan penyebaran angket ke para ahli maka dilakukan mengolah data menggunakan aplikasi SPSS untuk mendapatkan Interaclass Coefitien Corelation (ICC). Dari pengolahan data maka dapat hasil ICC lebih dari 0,50 maka dapat di simpulkan tingkat validasi adalah memadai; (2) Pengembangan media pembelajaran berbasis canva dapat dinyatakan sangat layak setelah melakukan pengolahan data, kelayakan dapat diukur menggunakan angket, angket diperoleh dari angket respon guru dengan responden 2 orang guru geografi dapat diperoleh hasil total skor 357 dengan mean 4,58 dan tingkat persentase 92% dengan predikat “sangat baik”; (3) Pengembangan media pembelajaran berbasis canva dapat dinyatakan sangat praktis setelah melakukan pengolahan data dari hasil penelitian diperoleh data menggunakan angket respon siswa diolah data menggunakan Microsoft Exel sehingga dari pengolahan data diperoleh sebesar 2829 dan didapat mean sebesar 4,57 dan persentase sebesar 91% dengan kategori “sangat praktis”.
ANALISIS KORELASI PROGRAM KELUARGA BERENCANA DENGAN ASPEK KESEHATAN DAN PENDIDIKAN SUMBER DAYA MANUSIA
Authors: Laksana Bayu Indra , Haris M. 
Published: August 2023

AbstrakTujuan penelitian ini untuk mengetahui hubungan program keluarga berencana dengan aspek kesehatan serta kualitas sumber daya manusia di kelurahan Simpang Baru Kecamatan Tampan Pekanbaru. Metode yang digunakan merupakan metode analisis deskriptif kuantitatif. Populasi dalam penelitian ini adalah seluruh peserta program keluarga berencana di Kelurahan Simpang Baru yang berjumlah 3462 kepala keluarga, sedangkan sampel yang ditentukan menggunakan rumus slovin berjumlah 193 responden. Dari hasil uji instrumen validitas menunjukkan bahwa semua item pertanyaan pada variabel program keluarga berencana dan kualitas sumber daya manusia adalah valid. Begitu juga perhiitungan hasil uji instrumen reliabilitas menunjukkan bahwa kedua variabel penelitian adalah reliabel, karena melewati angka 0,6 sebagai syarat keandalan instrumen. Berdasarkan dari hasil perhitungan korelasi penulis memperoleh nilai korelasi yang searah dan bernilai positif sebesar 0,865 yang menunjukkan bahwa terdapat hubungan yang kuat antara variabel program keluarga berencana dengan variabel kualitas sumber daya manusia terbukti pada penurunan angka kepadatan penduduk, pemahaman tentang kontrasepsi, penanggulangan kesehatan reproduksi dan peningkatan kesejahteraan keluarga..Kata Kunci: Program Keluarga Berencana, Kualitas Sumber Daya Manusia, PekanbaruAbstract The objective of this research is to know the correlation between the family planning program and the quality of human resources in kelurahan Simpang Baru kecamatan Tampan Pekanbaru. Method used in this research is descriptive quantitative method. Populations taken in this research are all participants the family planning program consisting of 3462 household’s heads. Samples are decided based on slovin formula, namely 193 respondents. According to the result of validity instrument test, all question items on the family planning program and the quality of human resource variables are valid. Furthermore, based on the calculation of reliability instrument test result, those two variables of research are reliable because they are beyond 0,6 as the requirement of instrument reliability. Based on the calculation of the correlation result, the researcher gets the positive and same direction correlation value which is 0,865. This value shows that there is a strong correlation between the family planning program variable and the quality of human resource as evidenced in the decrease in population density, understanding of contraception, reproductive health management and improvement family welfare.Keywords: The Family Planning Program, The Quality Of Human Resoursces, Pekanbaru