bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of percutaneous transluminal angioplasty and stenting vs aggressive medical management on Risk of Stroke and Death in Patients with stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis
Authors: Lai Zhiyu , Peng Mingqiang , Li Yingbin , Bai Xiaoxin , cai jun 
Published: February 2023

Abstract
Background: There are currently two treatment strategies mainly for high-risk patients: percutaneous transluminal angioplasty and stenting (PTAS) and aggressive medical management (AMM). However, the choice between PTAS or AMM remains controversial for patients with stroke or intracranial atherosclerotic stenosis (ICAS).
Methods: The investigators searched PubMed, Web of Science, Embase, Scopus, and Cochrane library databases. Randomized controlled trial (RCT) comparing the PTAS and AMM for patients with stroke or ICAS were selected. RevMan 5.3 was used to analyze the results and risk of bias. The primary endpoints are stroke and death within 30 days after enrollment, or ischemic stroke in the territory of the qualifying artery beyond 30 days, and entire follow-up endpoints. The secondary outcomes were the disabling or fatal stroke, and incidence of death within 3 years.
Results: Four studies, 989 patients were included in this article. The AMM group was superior in the entire follow-up endpoint (OR: 0.56; 95% CI: 0.40, 0.79). The AMM also better in primary endpoint within 30 days (OR: 0.32; 95% CI: 0.17, 0.61). There was no significant difference beyond 30 days (OR: 1.08; 95% CI: 0.63, 1.86). The remaining outcomes, such as stroke and death, were not significantly different (P>0.05).
Conclusion: This meta-analysis shows AMM is significantly more effective than PTAS in subjects with ICAS because of the high rate of periprocedural OR: 0.32; 95% CI: 0.17, 0.61) and entire follow-up (OR: 0.56; 95% CI: 0.40, 0.79) stroke from PTAS and the fact that PTAS offers no benefit over AMM beyond 30 days (OR: 1.08; 95% CI: 0.63, 1.86).
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses
Authors: Konopleva Marina , DiNardo Courtney , Bhagat Tushar , Baran Natalia , Lodi Alessia , Saxena Kapil , Cai Tianyu , Su Xiaoping , Skwarska Anna , Guerra Veronica , Kuruvilla Vinitha , Konoplev Sergej , Gordon-Mitchell Shanisha , Pradhan Kith , Aluri Srinivas , Collins Meghan , Sweeney Shannon , Busquet Jonathan , Rathore Atul , Deng Qing , Green Michael , Grant Steven , Demo Susan , Choudhary Gaurav , Sahu Srabani , Agarwal Beamon , Spodek Mason , Thiruthuvanathan Victor , Will Britta , Steidl Ulrich , Tippett George , Burger Jan , Borthakur Gautam , Jabbour Elias , Pemmaraju Naveen , Kadia Tapan , Kornblau Steven , Daver Naval , Naqvi Kiran , Short Nicholas , Garcia-Manero Guillermo , Tiziani Stefano , Verma Amit 
Published: February 2023

Abstract

Malignancies can become reliant on glutamine as an alternative energy source and as a facilitator of aberrant DNA methylation, thus implicating glutaminase (GLS) as a potential therapeutic target. We demonstrate preclinical synergy of telaglenastat (CB-839), a selective GLS inhibitor, when combined with azacytidine (AZA), in vitro and in vivo, followed by a phase Ib/II study of the combination in patients with advanced MDS. Treatment with telaglenastat/AZA led to an ORR of 70% with CR/mCRs in 53% patients and a median overall survival of 11.6 months. scRNAseq and flow cytometry demonstrated a myeloid differentiation program at the stem cell level in clinical responders. Expression of non-canonical glutamine transporter, SLC38A1, was found to be overexpressed in MDS stem cells; was associated with clinical responses to telaglenastat/AZA and predictive of worse prognosis in a large MDS cohort. These data demonstrate the safety and efficacy of a combined metabolic and epigenetic approach in MDS.
An Assessment of the Move Your Way Program Among Hispanic Adults in Las Vegas, Nevada
Authors: Bungum Timothy , Pharr Jennifer , Coughenour Courtney , Gakh Maxim 
Published: February 2023

Abstract
Background
Physical activity (PA) is important because of its associated health benefits. However, many Americans remain inactive. The federal government first adopted PA guidelines in 2008 and revised them in 2018. The 2018 guidelines recognize that PA bouts of less than 10 minutes are beneficial. The U.S. Department of Health and Human Services’ Office of Disease Prevention and Health Promotion created the Move Your Way® (MYW) campaign to provide PA resources for communities and healthcare providers. This study aims to describe the reach of the MYW campaign, and assess whether having seen, heard, or read (SHR) about MYW, or having seen the MYW logo, was associated with PA knowledge and self-efficacy, and PA behavior among Hispanics residing in the Las Vegas area. Methods: Hispanics, aged 18–74, were surveyed at community events (n = 481) or via an online survey (n = 123). Respondents were asked if they had SHR of MYW, were aware of 2018 PA recommendations and reported their personal PA behavior, PA knowledge, PA intentions, and demographics. Results: Respondents (71% female) completed a 38-42-item survey. Approximately (12.4%) had SHR of the MYW campaign and 16.1% had seen the MYW logo. Only 3.4% and 15% correctly identified, “150 minutes per week” and “75 minutes per week” as the 2018 guidelines for moderate physical activity (MPA) and vigorous physical activity (VPA), respectively. Those who had SHR of the MYW campaign were more likely to correctly identify 150 minutes per week as the MPA guideline and had greater confidence in overcoming selected PA barriers. Those who had seen the MYW logo were more apt to meet strength guidelines. Conclusions: Knowledge of the MYW program positively associates with some PA behaviors and PA correlates.
Gait Generation of Hexapod Robot for the CPG Controller by Using the Delayed Van der Pol Oscillators
Authors: Song Zigen , Zhu Jiayi , Xu Jian 
Published: February 2023

Abstract
In this study, we construct a type of CPG (central pattern generator) controller by using the delay-coupling Van der Pol (VDP) oscillators and propose an analysis method of parameter modulation to illustrate the locomotion gait of a hexapod robot. The structure topology of the CPG controller is scheduled as a unidirectional ring network consisting of six identical units. Each unit has independentparameters to modulate amplitude and frequency of the period activity. Employing the Hopf bifurcation, we first propose parameter conditions to guarantee the existence of the period activity for the delayed CPG controller, where coupling delay can induce generation and extinction of the period activity. Due to the symmetry structure of the proposed CPG controller, the period activity induced by coupling delay presents multiple spatiotemporal patterns with a constant phase difference. Based on theoretical analysis of the equivariant Hopf bifurcation, we further pinpoint parameter regions for the corresponding spatiotemporal patterns. Then using the invariable phase difference between signal outputs of the VDP oscillators, we assign connection order of the CPG units to link the hexapod’s legs and produce the hexapodal locomotion gaits. The results show that the coupling delay in the delayed VDP-CPG controller is an effective method to obtain many types of the hexapodal locomotion gaits.
Complete Chloroplast genomes of five Cuscuta species and their evolutionary significance in the Cuscuta genus
Authors: Pan Hangkai , Zagorchev Lyuben , Chen Luxi , Tao Yutian , Cai Chaonan , Jiang Ming , Sun Zhongshuai , Li Junmin 
Published: February 2023

Abstract
Background
Cuscuta, a parasitic plant species in the Convolvulaceae family, grows in many countries and regions. However, the relationship between some species is still unclear. Therefore, more studies are needed to assess the variation of the chloroplast genome in Cuscuta species and their relationship with subgenera or sections, thus, providing important information on the evolution of Cuscuta species.
Results
In the present study, we identified the whole chloroplast genomes of C. epithymum, C. europaea, C. gronovii, C. chinensis and C. japonica, and then constructed a phylogenetic tree of 23 Cuscuta species based on the genome sequences. We also compared the number of genes and the structure of chloroplast genome and the patterns of gene reduction. Most chloroplast genomes of Cuscuta spp. have tetragonal and circular structures except for C. epithymum, C. europaea, C. pedicellata and C. approximata. Moreover, a simple sequence repeat analysis showed that the Cuscuta chloroplast genome is species-specific. The inverted repeat boundaries of the four regions between different subgenera were similar. Gene rearrangement showed that different Cuscuta species in the same subgenus have similar chloroplast genome structures. Several chloroplast genes were lost. In addition, the numbers and types of the lost genes in the same subgenus were similar. Most of the lost genes were related to photosynthesis (ndh, rpo, psa, psb, pet, and rbcL). Thus, they could have gradually caused the plants to lose the ability to photosynthesize.
Conclusion
Our results enrich the data on cp genomes of genus Cuscuta. This study provides new insights into understanding the phylogenetic relationships and variations in the chloroplast genome of Cuscuta species.
Bioavailability of bioactive phytochemicals in selected tissues and excreta from goats fed hempseed cake (Cannabis sativa L.) finisher diets
Authors: Semwogerere Farouk , Chikwanha Obert C. , Katiyatiya Chenaimoyo L. F. , Marufu Munyaradzi C. , Mapiye Cletos 
Published: February 2023

Abstract
Hempseeds are rich in bioactive phytochemicals, yet little is known about their bioavailability in tissues and excreta of animals fed hemp seed cake. The study evaluated the bioactive phytochemicals and their antioxidant activity in blood, liver, meat, feces and urine from goats fed finishing diets containing graded inclusions of hempseed cake (HSC). Twenty-five wether goats (27 ± 3 kg) of 4-5 months were randomly allocated to five experimental diets containing increasing levels of HSC (0, 25, 50, 75, 100 g/kg DM) substituted for soybean meal (SBM) as the main protein source. Goats were adapted for 21 days, and blood, fecal and urine samples collected on day 28. The liver and right longissimus thoracis et lumborum were respectively collected 60 min and 24 h after slaughter. Linear increases (P ≤ 0.05) in blood, liver and urine magnesium, fecal manganese, and fecal copper were observed with increasing HSC inclusion in the diet. Liver and fecal selenium exhibited a decreasing linear trend (P ≤ 0.05) with HSC increment in diets. Diet did not affect (P > 0.05) meat and urine mineral contents, except urine magnesium. The 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; ABTS) of blood, liver, and meat linearly increased (P ≤ 0.05) with dietary inclusion of HSC. Blood and liver ferric reducing antioxidant power (FRAP) quadratically increased (P ≤ 0.05) with HSC inclusion reaching a maximum at 50 g/kg DM. Current results suggest that inclusion of HSC up to 100 g/kg substituting SBM in goat diets can improve bioavailability of bioactive phytochemicals in blood, liver, and meat.
Two Novel Lytic Bacteriophages having Therapeutic Potential against MDR Avian Pathogenic Escherichia coli strains of zoonotic potential
Authors: Sattar Sadia , Bailie Marc , Yaqoob Akasha , Khanum Sofia , Fatima Kaniz , Altaf Anees Ur Rehman Bin , Ahmed Ibrar , Shah Syed Tahir Abbas , Munawar Javeria , Zehra Quaratul Ain , Daud Sajeela , Arshad Ayesha , Imdad Kaleem , Javed Sundus , Tariq Amira , Bostan Nazish , Altermann Eric 
Published: February 2023

Abstract
Avian pathogenic E. coli (APEC) is associated with local and systemic infections in poultry, ducks turkeys and many other avian species which leads to heavy economical losses. These APEC strains are presumed to possess zoonotic potential due to common virulence markers that can cause urinary tract infections in humans. The prophylactic use of antibiotics in poultry sector has led to rapid emergence of Multiple Drug Resistant (MDR) APEC strains that also put human populations at risk acting as reservoirs. This calls for consideration of alternative strategies for their treatment such as phage therapy. Here, we report isolation, characterization, and genome analysis of two novel lytic phage species (Escherichia phage SKA49 and Escherichia phage SKA64) against MDR strain of APEC, QZJM25. Both phages were able to keep QZJM25 growth significantly less than bacterial control for approximately 18 hours. Host range was tested against Escherichia coli strains of poultry and human UTI infections. SKA49 had broader host range contrast to SKA64. Both phages were stable at 37°C only. Their genome analysis indicated their safety as no recombination, integration and host virulence genes were identified. Based on this analysis both these phages can be used as effective biocontrol agents in poultry industry.
Design of computer big data processing system based on genetic algorithm
Authors: Chen Song 
Published: February 2023

Abstract
In recent years, people have witnessed the rapid growth of data, and big data has penetrated into every aspect of people's lives. If a big data processing system wants to extract the hidden value behind massive data, it is inseparable from the support of a large number of underlying infrastructure resources. However, the one-time expensive investment in the initial economy and the complexity of the later work of operation and maintenance hinder the use of some small and medium-sized enterprises. Based on this background, with the continuous development of computer technology, this paper constructs a large-scale data processing system that introduces genetic algorithms, making full use of the advantages of on-demand self-service and the elastic expansion of computer technology, shortening the time required for data processing and data analysis. life cycle, so that more and more enterprises and organizations can start using big data processing technology. For fragmented big data obtained from different data sources, this paper adopts load balancing technology to provide horizontal service cluster scalability, and designs a separate system module for routine testing. The experimental results show that the designed function of the system can be realized, and the actual error is always lower than the specified error limit. It is hoped that the research work in this paper can provide useful reference and help for the design of computer big data processing system. This paper designs a kind of effective big data processing system by studying genetic algorithm and computer technology.
Delayed vascular complication after collagenase injection for Dupuytren disease
Authors: Nordenskjöld Jesper , Nilsson Jonas , Kalaf Roua , Atroshi Isam 
Published: February 2023

Abstract
Background
Vascular adverse events after collagenase injection for Dupuytren disease are absent in large trials and systematic reviews. The aim of this study is to present a case series of delayed vascular complications after collagenase treatment.
Methods
A prospective evaluation of 1181 consecutively treated patients at one orthopedic department identified three patients reporting symptoms of possible vascular complication. Baseline demographics and description of symptoms were collected, with a physical examination documenting extension deficit and neurovascular status. All patients completed the Cold Intolerance Symptom Severity (CISS) scale (range 4-100, lower is better) and underwent Doppler sonography examination of the digital arteries.
Results
All patients were treated in the small finger and two had an isolated proximal interphalangeal joint contracture. All patients had a delayed presentation of a few months, with episodes of white discoloration of the treated finger relieved within 30 minutes and associated with variable pain, paresthesia, stiffness and weakness. Two of the patients reported cold exposure as an episode trigger and had a pathological CISS score (40 and 36, respectively). Doppler sonography identified a nonpatent ulnar digital artery in one patient.
Conclusions
Delayed vascular complication after collagenase treatment is rare, but surgeons and patients should be aware of the risk, especially when treating the small finger.
Distributed adaptive PI consensus tracking control for output-constrained nonlinear multiagent systems with unknown control directions
Authors: Zhu Lingchen , Zhang Liuliu , Hua Changchun 
Published: February 2023

Abstract
This paper investigates the problem of distributed adaptive PI consensus tracking control for output-constrained nonlinear multiagent systems (MASs) with unknown control directions and unknown time-varying actuator faults under the directed graph. Firstly, an auxiliary filter network is constructed to estimate the output of the leader. Then, by introducing a nonlinear state transformation function, the asymmetric constraints on agents' outputs can be achieved with unconstrained initial conditions. Furthermore, based on the Nussbaum-type functions, a distributed adaptive PI controller is designed by utilizing the constructed generalized error for nonlinear MASs with unknown time-varying control directions caused by actuator faults. It is proved that the proposed control scheme can guarantee that all signals in the closed-loop system are bounded and the distributed asymptotic consensus tracking is achieved. Finally, a simulation example illustrates the effectiveness of the proposed control strategy.
The structural components of the Azotobacter vinelandii iron-only nitrogenase, AnfDKG, form a protein complex within the plant mitochondrial matrix
Authors: Johnston Ema , Okada Shoko , Gregg Christina , Warden Andrew , Rolland Vivien , Gillespie Vanessa , Byrne Keren , Colgrave Michelle , Eamens Andy , Allen Robert Silas , Wood Craig 
Published: February 2023

Abstract
A long-held goal of synthetic biology has been the transfer of a bacterial nitrogen-fixation pathway into plants to reduce the use of chemical fertiliser on crops such as rice, wheat and maize. There are three classes of bacterial nitrogenases, named after their unique metalloclusters containing either Mo-, V- or Fe, that convert N2 gas to ammonia. Relative to the Mo-nitrogenase the Fe-nitrogenase is not as efficient for catalysis but has less complex genetic and metallocluster requirements, features that may be preferable for engineering into crops. Here we report the successful targeting of bacterial Fe-nitrogenase proteins, AnfD, AnfK, AnfG and AnfH, to plant mitochondria. When expressed as a single protein AnfD was mostly insoluble in plant mitochondria, but coexpression of AnfD with AnfK greatly improved its solubility. Using affinity-based purification of mitochondrially expressed AnfK or AnfG we were able to demonstrate a strong interaction of AnfD with AnfK and a weaker interaction of AnfG with AnfDK. This work establishes that the structural components of the Fe-nitrogenase can be engineered into plant mitochondria and form a complex, which will be a requirement for function. This report outlines the first use of Fe-nitrogenase genes within a plant as a preliminary step towards engineering an alternative nitrogenase into crops.
The difference between two brachycephalic and one mesocephalic dog breeds' problem-solving performance suggests evidence for paedomorphism in behaviour
Authors: Ujfalussy Dorottya , Bognár Zsófia , Molnár Marianna , Miklósi Ádám , Kubiniy Enikő 
Published: February 2023

Abstract
Despite the serious problems with their general health and longevity, small brachycephalic breeds, especially the French bulldog, are becoming increasingly popular among pet owners. The motivations for the choice of short-nosed breeds have been extensively investigated in recent years; however, this issue has been addressed mainly by relying on owner reports, resulting in somewhat vague explanations of "cute looks", referring to the child-schema phenomenon and "behaviour well suited for companionship".
In this study, we set out to compare the behaviour of two brachycephalic (English and French bulldogs) and a mesocephalic (Hungarian mudi) breed in a problem-solving context. The dogs were given the task of opening boxes containing food rewards. We investigated human-directed behaviour elements over success and latency (indicators of motivation and ability).
...
We found that the short-headed breeds were less successful but much more oriented toward humans than mesocephalic dogs. Owners might interpret these behaviours as "helplessness" and dependence. The results support the hypothesis that infant-like traits may be present not only in appearance but also in behaviour in brachycephalic breeds, eliciting a caring behaviour in owners.
Simulation of agricultural digital economy development and policy support system based on resource sensitivity index
Authors: Dai Yanqing 
Published: February 2023

Abstract
The development of science and technology has also led to the progress of rural digital economy. In China, the construction of new countryside has always been an important part of economic development. The application of big data technology in rural areas can not only promote the development of rural economy, but also improve the results of environmental protection. Using the matching coefficient method of agricultural water and soil environmental characteristics, it match the rural water and soil environmental characteristics and the impact of the water environment in the autonomous region.An indispensable driving force in the process, agricultural digitalization will update the rural economic development model, weaken the barriers to the dual structure of urban and rural areas, stabilize agricultural production, promote sustainable rural development, and promote rural economic development. The current government policy support, the urgent need for new development momentum for rural economic development, and the advancement of changes in the lifestyle of urban and rural residents are promoting high-quality development of the rural economy. At the same time, we are facing challenges such as the lack of local network coverage, the lack of logistics, sales systems, and the lack of talents with digital skills. Expanding rural network coverage, optimizing rural logistics and distribution, promoting the development of agricultural big data, and strengthening the development of digital human resources are important ways for agricultural digitalization to promote rural economic development. The research focus of this paper is the parallel development of rural digital economy and environmental protection under the big data economy, and its application in the current agricultural development can achieve a win-win situation between man and nature.