bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of diabetes on temporal trends in lower extremity revascularisation and amputation for peripheral artery disease: A population‐based repeated cross‐sectional analysis
Authors: Jacob‐Brassard Jean , Al‐Omran Mohammed , Stukel Thérèse A. , Mamdani Muhammad , Lee Douglas S. , Papia Giuseppe , de Mestral Charles 
Published: February 2023

AbstractAim/HypothesisTo describe the influence of diabetes on temporal changes in rates of lower extremity revascularisation and amputation for peripheral artery disease (PAD) in Ontario, Canada.MethodsIn this population‐based repeated cross‐sectional study, we calculated annual rates of lower extremity revascularisation (open or endovascular) and amputation (toe, foot or leg) related to PAD among Ontario residents aged ≥40 years between 2002 and 2019. Annual rate ratios (relative to 2002) adjusted for changes in diabetes prevalence alone, as well as fully adjusted for changes in demographics, diabetes and other comorbidities, were estimated using generalized estimating equation models to model population‐level effects while accounting for correlation within units of observation.ResultsCompared with 2002, the Ontario population in 2019 exhibited a significantly higher prevalence of diabetes (18% vs. 10%). Between 2002 and 2019, the crude rate of revascularisation increased from 75.1 to 90.7/100,000 person‐years (unadjusted RR = 1.10, 95% CI = 1.07–1.13). However, after adjustment, there was no longer an increase in the rate of revascularisation (diabetes‐adjusted RR = 0.98, 95% CI = 0.96–1.01, fully‐adjusted RR = 0.94, 95% CI = 0.91–0.96). The crude rate of amputation decreased from 2002 to 2019 from 49.5 to 45.4/100,000 person‐years (unadjusted RR = 0.78, 95% CI = 0.75–0.81), but was more pronounced after adjustment (diabetes‐adjusted RR = 0.62, 95% CI = 0.60–0.64; fully‐adjusted RR = 0.58, 95% CI = 0.56–0.60).Conclusions/InterpretationDiabetes prevalence rates strongly influenced rates of revascularisation and amputation related to PAD. A decrease in amputations related to PAD over time was attenuated by rising diabetes prevalence rates.
Effects of finerenone in people with chronic kidney disease and type 2 diabetes are independent of HbA1c at baseline, HbA1c variability, diabetes duration and insulin use at baseline
Authors: McGill Janet B. , Agarwal Rajiv , Anker Stefan D. , Bakris George L. , Filippatos Gerasimos , Pitt Bertram , Ruilope Luis M. , Birkenfeld Andreas L. , Caramori Maria L. , Brinker Meike , Joseph Amer , Lage Andrea , Lawatscheck Robert , Scott Charlie , Rossing Peter ,   the FIDELIO‐DKD and FIGARO‐DKD investigators
Published: February 2023

AbstractAimTo evaluate the effect of finerenone by baseline HbA1c, HbA1c variability, diabetes duration and baseline insulin use on cardiorenal outcomes and diabetes progression.Materials and MethodsComposite efficacy outcomes included cardiovascular (cardiovascular death, non‐fatal myocardial infarction, non‐fatal stroke or hospitalization for heart failure), kidney (kidney failure, sustained ≥ 57% estimated glomerular filtration rate decline or renal death) and diabetes progression (new insulin initiation, increase in antidiabetic medication, 1.0% increase in HbA1c from baseline, new diabetic ketoacidosis diagnosis or uncontrolled diabetes).ResultsIn 13 026 participants, risk reductions in the cardiovascular and kidney composite outcomes with finerenone versus placebo were consistent across HbA1c quartiles (P interaction .52 and .09, respectively), HbA1c variability (P interaction .48 and .10), diabetes duration (P interaction .12 and .75) and insulin use (P interaction .16 and .52). HbA1c variability in the first year of treatment was associated with a higher risk of cardiovascular and kidney events (hazard ratio [HR] 1.20; 95% confidence interval [CI] 1.07‐1.35; P = .0016 and HR 1.36; 95% CI 1.21‐1.52; P < .0001, respectively). There was no effect on diabetes progression with finerenone or placebo (HR 1.00; 95% CI 0.95‐1.04). Finerenone was well‐tolerated across subgroups; discontinuation and hospitalization because of hyperkalaemia were low.ConclusionsFinerenone efficacy was not modified by baseline HbA1c, HbA1c variability, diabetes duration or baseline insulin use. Greater HbA1c variability appeared to be associated with an increased risk of cardiorenal outcomes.
Economic Notes: 1999–2011
Authors: Roma Antonio 
Published: February 2023

AbstractThe paper documents that, over the period 1999–2011, Economic Notes made a further step forward in becoming a professional outlet for high‐quality academic research by moving under the production and distribution by an international publisher (Blackwell, later on, Wiley). The Journal cultivated research on the challenges posed by an environment of financial innovation and security‐market expansion, which posed new economic policy and bank management issues. Accordingly, it refocused on compelling financial, banking and monetary topics, as epitomized by adopting its current subtitle ‘Review of Banking, Finance and Monetary Economics’. On balance, the Journal's long‐standing editorial policy of being open to a variety of contributions in the field of economics was retained, but a noticeable shift toward financial themes took shape over the 1999–2011 period. This focus, inspired by the events of the period, helped the Journal to remain relevant to the research interests of many scholars at the time. Notably, the Journal included topics in applied research that had a potential impact on the management of financial institutions, such as risk management and asset pricing, as well as the analysis of financial regulations. Those years proved fertile for both editorial policy and the dissemination of the Journal.
Is the future female for turtles? Climate change and wetland configuration predict sex ratios of a freshwater species
Authors: Roberts H. Patrick , Willey Lisabeth L. , Jones Michael T. , Akre Thomas S. B. , King David I. , Kleopfer John , Brown Donald J. , Buchanan Scott W. , Chandler Houston C. , deMaynadier Phillip , Winters Melissa , Erb Lori , Gipe Katharine D. , Johnson Glenn , Lauer Kathryn , Liebgold Eric B. , Mays Jonathan D. , Meck Jessica R. , Megyesy Joshua , Mota Joel L. , Nazdrowicz Nathan H. , Oxenrider Kevin J. , Parren Molly , Ransom Tami S. , Rohrbaugh Lindsay , Smith Scott , Yorks Derek , Zarate Brian 
Published: February 2023

AbstractClimate change and land‐use change are leading drivers of biodiversity decline, affecting demographic parameters that are important for population persistence. For example, scientists have speculated for decades that climate change may skew adult sex ratios in taxa that express temperature‐dependent sex determination (TSD), but limited evidence exists that this phenomenon is occurring in natural settings. For species that are vulnerable to anthropogenic land‐use practices, differential mortality among sexes may also skew sex ratios. We sampled the spotted turtle (Clemmys guttata), a freshwater species with TSD, across a large portion of its geographic range (Florida to Maine), to assess the environmental factors influencing adult sex ratios. We present evidence that suggests recent climate change has potentially skewed the adult sex ratio of spotted turtles, with samples following a pattern of increased proportions of females concomitant with warming trends, but only within the warmer areas sampled. At intermediate temperatures, there was no relationship with climate, while in the cooler areas we found the opposite pattern, with samples becoming more male biased with increasing temperatures. These patterns might be explained in part by variation in relative adaptive capacity via phenotypic plasticity in nest site selection. Our findings also suggest that spotted turtles have a context‐dependent and multi‐scale relationship with land use. We observed a negative relationship between male proportion and the amount of crop cover (within 300 m) when wetlands were less spatially aggregated. However, when wetlands were aggregated, sex ratios remained consistent. This pattern may reflect sex‐specific patterns in movement that render males more vulnerable to mortality from agricultural machinery and other threats. Our findings highlight the complexity of species' responses to both climate change and land use, and emphasize the role that landscape structure can play in shaping wildlife population demographics.
Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1‐deficient skin carcinoma
Authors: Kervarrec Thibault , Frouin Eric , Collin Christine , Tallet Anne , Tallegas Matthias , Pissaloux Daniel , Tirode Franck , Guyétant Serge , Samimi Mahtab , Gaboriaud Pauline , Touzé Antoine , Schrama David , Houben Roland , Tabareau‐Delalande Flore , Neuhart Anne , de la Fouchardière Arnaud , Osio Amélie , Cavelier–Balloy Bénédicte , Laurent‐Roussel Sara , Sohier Pierre , Cyprien Tilmant , Balme Brigitte , Belzung Fanny , Jullie Marie‐Laure , Cribier Bernard , Battistella Maxime , Macagno Nicolas 
Published: February 2023

AimsRecently, YAP1 fusion genes have been demonstrated in eccrine poroma and porocarcinoma, and the diagnostic use of YAP1 immunohistochemistry has been highlighted in this setting. In other organs, loss of YAP1 expression can reflect YAP1 rearrangement or transcriptional repression, notably through RB1 inactivation. In this context, our objective was to re‐evaluate the performance of YAP1 immunohistochemistry for the diagnosis of poroma and porocarcinoma.Methods and resultsThe expression of the C‐terminal part of the YAP1 protein was evaluated by immunohistochemistry in 543 cutaneous epithelial tumours, including 27 poromas, 14 porocarcinomas and 502 other cutaneous tumours. Tumours that showed a lack of expression of YAP1 were further investigated for Rb by immunohistochemistry and for fusion transcripts by real‐time PCR (YAP1::MAML2 and YAP1::NUTM1). The absence of YAP1 expression was observed in 24 cases of poroma (89%), 10 porocarcinoma (72%), 162 Merkel cell carcinoma (98%), 14 squamous cell carcinoma (SCC) (15%), one trichoblastoma and one sebaceoma. Fusions of YAP1 were detected in only 16 cases of poroma (n = 66%), 10 porocarcinoma (71%) all lacking YAP1 expression, and in one sebaceoma. The loss of Rb expression was detected in all cases except one of YAP1‐deficient SCC (n = 14), such tumours showing significant morphological overlap with porocarcinoma. In‐vitro experiments in HaCat cells showed that RB1 knockdown resulted in repression of YAP1 protein expression.ConclusionIn addition to gene fusion, we report that transcriptional repression of YAP1 can be observed in skin tumours with RB1 inactivation, including MCC and a subset of SCC.
Infants use contextual memory to attend and learn in naturalistic scenes
Authors: Tummeltshammer Kristen , Amso Dima 
Published: February 2023

AbstractInfants encounter new objects and learn about object features in relation to a rich and detailed visuospatial context. Using a contextual cueing task, recent work showed that 6‐ and 10‐month‐old infants search more efficiently for target objects in repeated rather than novel visuospatial contexts (i.e., arrays of shapes on a blank background). Here, we investigate whether infants' sensitivity to visuospatial context scales up to more complex and potentially more distracting, naturalistic scenes. In an eye‐tracking task, 8‐month‐olds searched for a novel target object in colorful photographs of everyday environments (e.g., bedrooms and kitchens). Repeated (“Old”) contexts co‐varied with target locations, such that the target object appeared in exactly the same location on the same scene, while varying (“New”) contexts contained target objects placed in different counterbalanced locations across a variety of scenes. Infants exhibited faster search times, more anticipation of target animation, and longer looking at targets that appeared in Old relative to New contexts. In a subsequent memory test, infants showed better recognition of label‐object pairings for target objects that had appeared in Old, rather than New, contexts. These results indicate that infants can use visuospatial contextual information in complex naturalistic scenes to facilitate memory‐guided attention and learning of object‐paired labels.
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
Authors: Wang Haiyan , Yan Yongyong , Pathak Janak L. , Hong Wei , Zeng Jing , Qian Dongyang , Hao Binwei , Li Haiqing , Gu Jinlan , Jaspers Richard T. , Wu Gang , Shao Ming , Peng Gongyong , Lan Haifeng 
Published: February 2023

AbstractDue to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti‐inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague–Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra‐articular injection), and three quercetin‐treated groups. Quercetin‐treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High‐dose quercetin‐group joints showed failure in OA progression. High‐dose quercetin inhibited the OA‐induced expression of MMP‐3, MMP‐13, ADAMTS4, and ADAMTS5 and promoted the OA‐reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high‐dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high‐dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups.
Alternative hypotheses regarding the association between early engagement in gambling and gambling‐like activities and later problem gambling – a commentary on Richard and King (2023)
Authors: Rhee Soo Hyun , Ellingson Jarrod M. 
Published: February 2023

This issue of the Journal of Child Psychology and Psychiatry includes a systematic review on the emergence of problem gambling from childhood to emerging adulthood (Richard & King, 2023). The importance of understanding the risks for problem gambling earlier in development is clear, given the increasing availability of gambling to minors, especially online gambling.
Caregivers' nutrition‐related knowledge, perceptions, practices and barriers regarding the therapeutic diet for classical galactosaemia
Authors: Blaauw Giana F. , Dolman‐Macleod Robin C. , Van Niekerk Evette 
Published: February 2023

AbstractBackgroundClassical galactosaemia is a life‐threatening disorder of carbohydrate metabolism, and the primary treatment is a lifelong galactose‐restricted diet commenced in infancy. Adherence to restrictive diets can be burdensome for patients and their families; however, little is known about the impact on caregivers.AimThis study aims to determine the nutrition‐related knowledge, perceptions, practices, and barriers of caregivers related to the therapeutic diet for classical galactosaemia.MethodsAn online survey was conducted among 98 eligible members of the Galactosaemia Support Group using a novel questionnaire. Descriptive and inferential analyses were performed using Microsoft Excel 2021 and Stata/MP (version 17.0), respectively. Forty‐three caregivers participated in the study.Results and ConclusionOf those who participated, 98% had high levels of dietary knowledge. Caregivers' knowledge scores ( = 17.9, standard deviation [SD] = 1.7) were positively correlated with educational level (r = 0.383, p = 0.013). High attitudinal scores ( = 32.5, SD = 5.5) obtained by most caregivers (65%) revealed an overall positive attitude towards the galactosaemia diet. Negative perceptions of being unable to feed their child breast milk (49%) were apparent, and this perception was positively correlated with caregivers' intention to feed their child breast milk (r = 0.450, p = 0.003). Caregivers' concerns about the safety of their child in social settings (79%) and feeling that their child was excluded in social settings (49%) were clear barriers. A multidisciplinary approach to galactosaemia management is warranted, with healthcare interventions focusing on addressing caregivers' negative perceptions and barriers related to the diet to enable tailored support and facilitate lifelong compliance.
B‐cell and T‐cell receptor repertoire in chronic inflammatory demyelinating polyneuropathy, a prospective cohort study
Authors: van Lieverloo G. G. A. , Al‐Soudi A. , Wieske L. , Klarenbeek P. L. , Anang D. C. , Adrichem M. E. , Niewold I. , van Schaik B. D. C. , van Kampen A. H. C. , van Schaik I. N. , de Vries N. , Eftimov F. 
Published: February 2023

AbstractThe immunopathophysiological mechanisms underlying chronic inflammatory demyelinating polyneuropathy (CIDP) in an individual patient are largely unknown. Better understanding of these mechanisms may aid development of biomarkers and targeted therapies. Both B‐ and T‐cell dominant mechanisms have been implicated. We therefore investigated whether B‐cell and T‐cell receptor (BCR/TCR) repertoires might function as immunological biomarkers in CIDP. In this prospective cohort study, we longitudinally sampled peripheral blood of CIDP patients in three different phases of CIDP: starting induction treatment (IT), starting withdrawal from IVIg maintenance treatment (MT), and patients in remission (R). BCR and TCR repertoires were analyzed using RNA based high throughput sequencing. In baseline samples, the number of total clones, the number of dominant BCR and TCR clones and their impact on the repertoire was similar for patients in the IT, MT, and remission groups compared with healthy controls. Baseline samples in the IT or MT did not predict treatment response or potential relapse at follow‐up. Treatment responders in the IT group showed a potential IVIg‐induced increase in the number of dominant BCR clones and their impact at follow‐up (baseline1.0 [IQR 1.0‐2.8] vs. 6 m 3.5 [0.3‐6.8]; P < .05, Wilcoxon test). Although the BCR repertoire changed over time, the TCR repertoire remained robustly stable. We conclude that TCR and BCR repertoire distributions do not predict disease activity, treatment response or response to treatment withdrawal.
The longitudinal link between popularity, likeability, fear of negative evaluation and social avoidance across adolescence
Authors: Henricks Lisan A. , Lange Wolf‐Gero , Luijten Maartje , van den Berg Yvonne H. M. , Stoltz Sabine E. M. J. , Cillessen Antonius H. N. , Becker Eni S. 
Published: February 2023

AbstractThis study investigated the longitudinal bidirectional associations between likeability, popularity, fear of negative evaluation, and social avoidance, to aid in preventing the negative consequences and persistent trajectories of low social status and heightened social anxiety. In total, 1741 adolescents in grades 7–9 participated at 3 yearly waves. A self‐report questionnaire measured fear of negative evaluation. Peer nominations assessed likeability, popularity, and social avoidance. Lower popularity predicted more avoidance, and vice versa. More avoidance was related to lower likeability over time. Being less popular and/or more liked by peers, increased fear of negative evaluation. Support for a transactional model between social anxiety and social status was found, but distinguishing different social status and social anxiety components is necessary.
Long‐term acoustic monitoring of nonstereotyped blue whale calls in the southern Indian Ocean
Authors: Torterotot Maëlle , Samaran Flore , Royer Jean‐Yves 
Published: February 2023

AbstractMonitoring the presence of blue whale (Balaenoptera musculus ssp.) stereotyped calls has been a widely used method to assess the different populations' distribution worldwide. All blue whale populations also produce nonstereotyped vocalizations, or D‐calls. Here, we monitored the presence of D‐calls in long‐term records from a large hydrophone array located in the open southern Indian Ocean, using an automated detection method and manual validation of the detections. D‐calls were detected at all sites of the array, which extends from 24°S to 56°S, but the majority of them were detected at the two southernmost sites. We observed a latitudinal shift in their seasonal occurrence, with more D‐calls in the north during austral autumn and winter and more in the south during austral spring. The geographical occurrence of D‐calls compared to that of songs indicates that blue whale acoustic behavior switches from a song‐intensive and sparse‐D‐call emission in the north to song‐moderate and more intensive D‐call emissions in the south. These findings support the hypothesis that both call types are used for different purposes, as D‐calls are mainly detected around foraging grounds and songs in wintering grounds. Monitoring both call types might therefore be a relevant acoustic indicator of blue whale behavior.
Obesity and weight change during the COVID‐19 pandemic in children and adults: A systematic review and meta‐analysis
Authors: Anderson Laura N. , Yoshida‐Montezuma Yulika , Dewart Nora , Jalil Ezza , Khattar Jayati , De Rubeis Vanessa , Carsley Sarah , Griffith Lauren E. , Mbuagbaw Lawrence 
Published: February 2023

SummaryMany obesity risk factors have increased during the COVID‐19 pandemic, including physical inactivity, poor diet, stress, and poverty. The aim of this systematic review was to evaluate the impact of the COVID‐19 pandemic, as well as associated lockdowns or restrictions, on weight change in children and adults. We searched five databases from January 2020 to November 2021. We included only longitudinal studies with measures from before and during the pandemic that evaluated the change in weight, body mass index (BMI) (or BMI z‐scores for children), waist circumference, or the prevalence of obesity. Random effects meta‐analyses were conducted to obtain pooled estimates of the mean difference in outcomes. Subgroups were evaluated for age groups and diabetes or obesity at baseline. The risk of bias was assessed using a modified version of the Newcastle‐Ottawa Scale, and the certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. A total of 74 studies were included (3,213,776 total participants): 31 studies of children, 41 studies of adults, and 2 studies of children and adults. In children, the pooled mean difference was 1.65 kg (95% confidence interval [CI]: 0.40, 2.90; 9 studies) for weight and 0.13 (95% CI 0.10, 0.17; 20 studies) for BMI z‐scores, and the prevalence of obesity increased by 2% (95% CI 1%, 3%; 12 studies). In adults, the pooled mean difference was 0.93 kg (95% CI 0.54, 1.33; 27 studies) for weight and 0.38 kg/m2 (95% CI 0.21, 0.55; 25 studies) for BMI, and the prevalence of obesity increased by 1% (95% CI 0%, 3%; 11 studies). In children and adults, the pooled mean difference for waist circumference was 1.03 cm (95% CI −0.08, 2.15; 4 studies). There was considerable heterogeneity observed for all outcomes in both children and adults, and the certainty of evidence assessed using GRADE was very low for all outcomes. During the first year of the COVID‐19 pandemic, small but potentially clinically significant increases in weight gain, BMI, and increased prevalence of obesity in both children and adults were observed. Increases were greater in children, and targeted prevention interventions may be warranted.