bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syndemic health crises—The growing role of National Public Health Institutes in shaping a coordinated response
Authors: Tweed Sam , Selbie Duncan , Tegnell Anders , Viso Anne‐Catherine , Ahmed Abdifatah , Mastkov Oleksandr , Pendergast Scott , Squires Neil 
Published: March 2023

AbstractCountries across the world are experiencing syndemic health crises where infectious pathogens including COVID‐19 interact with epidemics of communicable and non‐communicable diseases. Combined with war, environmental instability and the effects of soaring inflation, a public health crisis has emerged requiring an integrated response. Increasingly, national public health institutes (NPHIs) are at the forefront of leading this, as demonstrated at the 2022 Annual Meeting of the International Association of National Public Health Institutes (IANPHI). These effects are particularly evident where conflict is exacerbating health crises in Ukraine and Somalia. In Ukraine, medical and public health workers have been killed and infrastructure destroyed, which require major efforts to rebuild to international standards. In Somalia, these crises are magnified by the effects of climate change, leading to greater food insecurity, heat‐related deaths and famine. National public health institutes are crucial in these contexts and many others to support integrated political responses where health challenges span local, national and international levels and involve multiple stakeholders. This can be seen in strengthening of Integrated Disease Surveillance and work towards the Sustainable Development Goals. National public health institutes also provide integration through the international system, working jointly to build national capacities to deliver essential public health functions. In this context, the 2022 IANPHI Annual meeting agreed the Stockholm Statement, highlighting the role that NPHIs play in tackling the causes and effects of interconnected global and local challenges to public health. This represents an important step in addressing complex health crises and syndemics which require whole‐of‐society responses, with NPHIs uniquely placed to work across sectors and provide system leadership in response.
Exploring individuals' workplace spirituality in the context of their work teams: A qualitative multi‐case, multi‐team study
Authors: McClurg Nandini (Nan) Oza , Ellinger Andrea D. , McWhorter Rochell , Osman‐Gani AAhad 
Published: March 2023

AbstractSpirituality has been associated with a person's desire to perform meaningful work and to feel connected with the community that is being served through this work. Since most adults spend a large amount of their productive hours at work pursuing meaning and purpose in their jobs, the concept of workplace spirituality (WS) has gained considerable attention. The nature of work has also increasingly shifted to the use of teams of expert talent to solve complex problems, thus calls for further research on team member behaviors that effect team productivity and team member motivation have been made. With the prevalence of work teams, a better understanding of individuals' WS in work teams is needed, yet, limited empirical research has been conducted on this topic. Therefore, the purpose of this study was to better understand how individuals express and experience WS within their work teams and how their WS influences their work teams. A qualitative multi‐case, multi‐team design was employed using face‐to‐face, semi‐structured individual interviews, collective work team interviews, observations, and field notes as the primary approaches to data collection. Data analyzed in this study using thematic analysis included 19 individual team member interviews, and six collective team interviews representing a total of six teams across two organizations. The findings and contributions of this study are presented, along with a future research agenda.
Efficacy and safety of lemborexant as an alternative drug for patients with insomnia taking gamma‐aminobutyric acid–benzodiazepine receptor agonists or suvorexant
Authors: Okino Kazumaro , Suzuki Hirohisa , Tomioka Hiroi , Sanada Kenji , Kawai Keita , Iwanami Akira , Inamoto Atsuko 
Published: March 2023

AbstractBackgroundAlthough gamma‐aminobutyric acid–benzodiazepine (GABA‐BZ) receptor agonists are used to treat insomnia, their long‐term or high‐dosage use causes adverse events. Nevertheless, evidence regarding the discontinuation and replacement of GABA‐BZ receptor agonists with alternative agents is lacking. Suvorexant (SUX), an existing orexin receptor antagonist, is effective in preventing nocturnal awakening in 70%–75% of patients with insomnia.MethodsThe novel dual orexin receptor antagonist lemborexant (LEM) has fewer adverse effects than GABA‐BZ receptor agonists. Therefore, in this retrospective study, we categorised patients taking GABA‐BZ receptor agonists and SUX into LEM‐treated (switched) and non‐treated (non‐switched) groups and compared their outcomes over a 12‐week period.ResultsThe GABA‐BZ group (N = 59) comprised 34 ‘switched’ and 25 ‘non‐switched’ and the SUX group (N = 14) comprised 6 ‘switched’ and 8 ‘non‐switched’ patients. A mixed model showed a significant diazepam equivalence reduction in patients taking GABA‐BZ receptor agonists and improved Athens Insomnia Scale score in those taking SUX. The safety and tolerability of GABA‐BZ receptor agonists and SUX were high, and no serious adverse effects were observed after switching to LEM.ConclusionsLemborexant may be a useful alternative for long‐term GABA‐BZ receptor agonist users. For SUX, the number of cases (N = 6) was insufficient to draw definite conclusions.
Anodic Fluorination, Methoxylation, Acetoxylation, and Cyanation of Heteroatom Organic Compounds Using Boron‐Doped Diamond, GC, and Pt Electrodes
Authors: Nojima Hideyuki , Shimoda Takashi , Inagi Shinsuke , Fuchigami Toshio 
Published: March 2023

AbstractVarious anodic substitution reactions such as fluorination, methoxylation, acetoxylation, and cyanation of heteroatom compounds containing a sulfur or nitrogen atom were comparatively studied using boron‐doped diamond (BDD), Pt, and glassy carbon (GC) anodes. It was found that BDD anode is highly effective for these anodic substitution reactions similarly to Pt anode although both BDD and GC electrodes are carbon‐based materials.
Advanced imaging system for brain tumor automatic classification from MRI images using HOG and BOF feature extraction approaches
Authors: Shaker Esraa Asem , El‐Hossiny Ahmed S. , Kandil Ahmed Hisham , Elbialy Ahmed , Afify Heba M. 
Published: March 2023

AbstractBrain tumors have recently become a widespread phenomenon that affects almost all age ranges. Magnetic resonance imaging (MRI) is a widely used technique nowadays to diagnose this life‐threatening disease. Therefore, using a computer‐aided diagnosis system is essential for the early identification and classification of brain tumors. This work aims to develop a fully automated classification framework for MRI brain tumor images using machine learning (ML) algorithms. In this article, four ML algorithms such as support vector machines (Cubic SVM), k‐nearest neighbors (fine KNN), decision tree (fine tree), and naive Bayes (Kernel) were implemented with two feature extraction approaches: histogram of oriented gradients (HOG) and a bag of features (BOF) approach. The novelty of this work is based on the original usage of BOF and HOG approaches over different types of ML algorithms for MRI brain tumor image classification. In addition, combining two public datasets that contain three brain tumor types to generalize and improve the proposed work. The results showed that the fine KNN algorithm achieved the greatest success among all algorithms using the HOG method with an accuracy of 98.62% on 6328 MRI images.
FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression
Authors: Zou Junwei , Huang Yong , Chen Yuan , Wu Zhaoying , Xie Hao , Zhou Hailang , Xing Chungen 
Published: March 2023

AbstractColorectal cancer (CRC) ranks as the most common gastrointestinal solid carcinoma globally. Substantial evidence has established a pivotal role for circular RNAs (circRNAs) in CRC progression. In this study, differentially expressed circRNAs were analyzed based on a public dataset (GSE126094) and elevated expression of circCASK (hsa_circ_0001917) was validated in CRC. Moreover, increased circCASK was also confirmed in CRC patients. Functionally, circCASK knockdown led to a significant decrease in CRC cell growth and attenuated cell migration and invasion. Similarly, circCASK knockdown markedly attenuated tumor growth in vivo. Mechanistically, circCASK sponged miR‐1271‐5p and enhanced sine oculis homeobox homolog 1 (SIX1) expression. More importantly, both SIX1 overexpression and miR‐1271‐5p knockdown could reverse the cellular behavior inhibition induced by circCASK knockdown. Furthermore, SIX1 was most strongly and positively linked with Wnt/β‐catenin signaling pathways, circCASK triggered Wnt/β‐catenin signaling through the miR‐1271‐5p/SIX1 axis, and FOXC2 transcriptionally induced circCASK expression. In conclusion, circCASK induced by FOXC2 accelerated CRC progression through the miR‐1271‐5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis.
Effect of titanium nanostructured surface on fibroblast behavior
Authors: Vrchovecká Kateřina , Kuta Jan , Uher Martin , Přibyl Jan , Pávková Goldbergová Monika 
Published: March 2023

AbstractAs the consumption of implants increases, so do the requirements for individual types of implants, for example, improved biocompatibility or longevity. Therefore, the nano‐modification of the titanium surface is often chosen. The aim was to characterize the modified surface with a focus on medical applications. The titanium surface was modified by the anodic oxidation method to form nanotubes. Subsequently, the material was characterized and analyzed for medical applications—surface morphology, surface wettability, chemical composition, and release of ions into biological fluids. A human gingival fibroblasts (HGFb) cell line was used in the viability study. A homogeneous layer of nanotubes of defined dimensions was formed on the titanium surface, ensuring the material's biocompatibility—the preparation conditions influence the resulting properties of the nanostructured surface. Nanostructured titanium exhibited more suitable characteristics (e.g., wettability, roughness, ion release) for biological applications than compared to pure titanium. It was possible to understand the behavior of the modified layer on the titanium surface and its effect on cell behavior. Another contribution of this work is the combination of material characterization (ion release) with the study of cytocompatibility (direct contact of cells with metals).
Upregulation of ENKD1 disrupts cellular homeostasis to promote lymphoma development
Authors: Song Ting , He Na , Hao Ziqian , Yang Yunfan 
Published: March 2023

AbstractDiffuse large B cell lymphoma (DLBCL) is a common and aggressive form of B cell lymphoma. Approximately 40% of DLBCL patients are incurable despite modern therapeutic approaches. To explore the molecular mechanisms driving the growth and progression of DLBCL, we analyzed genes with differential expression in DLBCL using the Gene Expression Profiling Interactive Analysis database. Enkurin domain‐containing protein 1 (ENKD1), a centrosomal protein‐encoding gene, was found to be highly expressed in DLBCL samples compared with normal samples. The phylogenetic analysis revealed that ENKD1 is evolutionarily conserved. Depletion of ENKD1 in cultured DLBCL cells induced apoptosis, suppressed cell proliferation, and blocked cell cycle progression in the G2/M phase. Moreover, ENKD1 expression positively correlates with the expression levels of a number of cellular homeostatic regulators, including Sperm‐associated antigen 5, a gene encoding an important mitotic regulator. These findings thus demonstrate a critical function for ENKD1 in regulating the cellular homeostasis and suggest a potential value of targeting ENKD1 for the treatment of DLBCL.
Longitudinal changes in subgingival biofilm composition following periodontal treatment
Authors: Johnston William , Rosier Bob T. , Carda‐Diéguez Miguel , Paterson Michael , Watson Paddy , Piela Krystyna , Goulding Marilyn , Ramage Gordon , Baranyia Divyashri , Chen Tsute , Al‐Hebshi Nezar N. , Mira Alex , Culshaw Shauna 
Published: March 2023

AbstractBackgroundCurrent periodontal treatment involves instrumentation using hand and/or ultrasonic instruments, which are used either alone or in combination based on patient and clinician preference, with comparable clinical outcomes. This study sought to investigate early and later changes in the subgingival biofilm following periodontal treatment, to identify whether these changes were associated with treatment outcomes, and to investigate whether the biofilm responded differently to hand compared with ultrasonic instruments.MethodsThis was a secondary‐outcome analysis of a randomized‐controlled trial. Thirty‐eight periodontitis patients received full‐mouth subgingival instrumentation using hand (n = 20) or ultrasonic instrumentation (n = 18). Subgingival plaque was sampled at baseline and 1, 7, and 90 days following treatment. Bacterial DNA was analyzed using 16S rRNA sequencing. Periodontal clinical parameters were evaluated before and after treatment.ResultsBiofilm composition was comparable in both (hand and ultrasonics) treatment groups at all time points (all genera and species; p[adjusted] > 0.05). Large‐scale changes were observed within groups across time points. At days 1 and 7, taxonomic diversity and dysbiosis were reduced, with an increase in health‐associated genera including Streptococcus and Rothia equating to 30% to 40% of the relative abundance. When reassessed at day 90 a subset of samples reformed a microbiome more comparable with baseline, which was independent of instrumentation choice and residual disease.ConclusionsHand and ultrasonic instruments induced comparable impacts on the subgingival plaque microbiome. There were marked early changes in the subgingival biofilm composition, although there was limited evidence that community shifts associated with treatment outcomes.
Hospital volume as a predictor of outcomes following pediatric thyroidectomy
Authors: Yu Victor J. , Sasson Daniel Cyrus , Scholfield Daniel , Woods Robbie , Wong Richard , Shaha Ashok , Shah Jatin , Ganly Ian , Lopez Joseph 
Published: March 2023

AbstractBackgroundPediatric thyroidectomy (PT) is an uncommon procedure with a risk of significant morbidity. This study utilizes a national database to identify factors associated with short‐term (30‐day) post‐thyroidectomy complications in children with thyroid cancer.MethodsThe 2016 and 2012 Kids' Inpatient Databases (KID) were used in this study. All children with thyroid cancer undergoing thyroidectomy were included. Complications were categorized into endocrine, nervous, pulmonary, and other. Hospital volume was stratified into high‐volume (performing the top 10% of total cases, HVC) or non‐high‐volume centers (NHVC). Risk factors were analyzed using univariable and multivariable statistical tests.ResultsSix hundred and sixty‐three patients with an average age of 15.93 years met inclusion criteria. Most patients were seen in an NHVC (90.0%) and 37.3% of thyroidectomies were performed with neck dissections. The incidence of any complication was 32.1%. Endocrine complications were the most frequent (32.7%). Independent predictors of any or only endocrine complications were age (odds ratio [OR] = 0.927, p = 0.002, any; OR = 0.926, p = 0.003, endocrine) or concurrent neck dissection (OR = 1.679, p = 0.004, any; OR = 1.683, p = 0.005, endocrine). There was no statistically significant change in odds with hospital volume.ConclusionsFurther investigation into the effect of single surgeon versus hospital volume on the risk of complications in pediatric thyroid cancer surgery is warranted.
Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway
Authors: Liang Lu‐Chang , Zhao Lei , Yu Bo , Hu Han‐Xiang , He Xu‐Hua , Zhang Yan‐Min 
Published: March 2023

AbstractChemotherapy is one of the common treatment methods for breast cancer, but chemoresistance is a severe challenge. Caffeic acid phenethyl ester (CAPE) is an active ingredient of propolis extract and has been shown to have a variety of beneficial effects, and its potential as a treatment for breast cancer is worth exploring. The effects of CAPE on doxorubicin (DOX) resistance were determined by cell counting kit‐8 (CCK‐8) assay, colony‐formation assay, and flow cytometry. Oil Red O staining and the detection of free fatty acids, triglycerides, phospholipids, and cholesterol were performed to assess the status of lipid metabolism. Quantitative polymerase chain reaction (qPCR) and western blotting were applied to investigate the molecules involved in lipid metabolism and the protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/sterol regulatory element binding protein 1 (SREBP1) pathway. CAPE treatment reversed DOX resistance in breast cancer cells and suppressed their lipid metabolism. In addition, CAPE combined with DOX remarkably suppressed SREBP1 expression in part by inhibiting Akt/mTOR pathway activation. Furthermore, by inhibiting lipid metabolism, partly via the Akt/mTOR/SREBP1 pathway, CAPE ultimately reversed DOX resistance in breast cancer. Our results suggest that CAPE treatment reversed DOX resistance in breast cancer cells, at least in part by inhibiting Akt/mTOR/SREBP1 pathway‐mediated lipid metabolism, indicating that CAPE may be an effective substance to assist in the treatment of breast cancer.
Skin‐Inspired Tough Elastomer with Moisture‐Triggered Switchable Mechanical Properties
Authors: Xu Ruoyu , Bai Jing , Zhou Shuai , Shi Zixing 
Published: March 2023

AbstractBiological tissue usually exhibits good water adaptive mechanical properties, which can maintain high strength and toughness in both wet and dry states. However, synthetic tissue like hydrogel usually becomes hard and brittle in its dry state. Herein, this challenge is met by exploring iron‐catechol complex (TA‐Fe3+) as a great platform combining extremely different polymers (elastomer and hydrogel) to construct new tissue‐like soft composite materials with two different continuous phases, which have not yet been reported. In its dry state, the xerogel phase becomes a reinforced segment to increase the strength of PB without losing its toughness. In its wet state, this soft material becomes high performance hydrogel, where hydrogel phase absorbs high water and elastomer phase can sustain high loading. Such heterogeneous phase structures provide a good idea for designing the soft materials, exhibiting a trade‐off between its high strength and toughness in both wet and dry states. Furthermore, its shape memory behaviors in both its wet and dry state, which shows a great potential application for complex adaptive shape transformation and engineering application like lifting of heavy objects under remote control due to high photo‐thermal transition of TA‐Fe3+ is explored.
Information gain in alternative data: Evidence from e‐commerce sales and analyst earnings forecasts
Authors: Niu Ruiyang , Xie Guanghua , Chen Lin , Zhao Longfeng , Wu Meijun 
Published: March 2023

AbstractBased on the e‐commerce sales data of A‐share listed firms in China, we explore how e‐commerce sales information affects analyst earnings forecasts. We find that firms' e‐commerce sales information is related to firms' value, increases firms' information transparency, broadens analysts' information channels, and thus improves analyst forecast behavior. Further analysis shows that e‐commerce sales information's positive effect is more significant in firms with high growth ability, low financial information transparency, and without management earnings forecasting. We also find that the positive effect is more salient in the bull market. The findings provide new insights for improving the analyst earnings forecast and offer evidence for the positive significance of e‐commerce sales of alternative data for the capital market in the information era.
A wideband monopolar patch antenna with a high system fidelity factor for IR‐UWB application
Authors: Huang Chaogui , Yang Wei , Chen Bo , Lei Shiwen , Hu Haoquan , Huang Wei 
Published: March 2023

AbstractA compact, broadband microstrip patch antenna with stable monopole‐like radiation patterns is proposed for impulse‐radio ultrawideband (IR‐UWB) positioning systems. Such the antenna consists of a circular patch with eight conductive vias placed concentrically, resulting in the and modes. Moreover, a tapered feeding probe at its center is presented to enhance the matching and excite an antiresonance mode. The compact size of is obtained by using a square ground. The measured results show that the antenna has an impedance bandwidth of 44.1% from 6 to 9.4 GHz and stable monopole‐like radiation patterns in the frequency domain. Finally, a system fidelity factor larger than 96% and a relatively stable group delay are simulated and measured in the time domain. Therefore, this antenna can be potentially useful for UWB pulse transmission with attractive features in engineering applications.
Circularly polarized edge‐placed printed monopole antenna using theory of characteristic modes
Authors: Ellis Mubarak S. , Owusu‐Achiaw Nana A. , Osei Stephen A. , Nakojah David 
Published: March 2023

AbstractThis article presents a method of using modal analysis to characterize the circular polarization (CP) performance of a printed monopole antenna. The radiator and feedline are positioned on the edge of the substrate and fed accordingly at the edge, and a modified ground plane is employed. The complete antenna without excitation is analyzed using characteristic mode theory to provide physical insight into its CP operation. The modal analysis proves that several nearly orthogonal modes can be generated at certain frequencies with orthogonal phase differences as well. The axial ratio (AR) corresponds to the modal analysis which proves the validity of the modal analysis. An axial ratio bandwidth from 3.1 to 6.2 GHz (66. 7%) is achieved within an S11 bandwidth of 2.6–11 GHz (123.5%). The proposed antenna is compact with stable radiation patterns, easy to design, and fabricate without inserting parasitic patches or inserting slots on the antenna.