bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of IL1β Gene in Sudanese Patients with Gliomas Tumor in Khartoum state, Sudan
Authors: Ebraheem Fadwa Mohammed , Alfatih Doha Mohammed , Abuzied Mohammed Abdulelah , Mohammed Bahja Abdu , Rhoma Aisha Ali , Ebrahim Fatma Zein Elabdeen , Ahmed Enas Alzain , Aldeaf Sawsan Ahmed , Gasoom Elsadig 
Published: December 2022

Introduction: Gliomas are the most prevalent type of primary intracranial tumors, representing 80% of all brain neoplasms.In Sudan Brain tumors have been as leading cause of mortality among children and as thirdcausative death among young adults.World Health Organization (WHO) classification2021, categorized gliomas into lower-grades gliomas (LGG,grades II and III) andglioblastoma (GBM, grade IV).Gliomas are surrounded by pool of pro inflammatory cytokines, chemokine and growth factor, particularly review the tumorigenic effects of central nervous system one of this inflammatory cytokines is Interleukin-1ß (IL-1ß ) which play a crucial role in gliomas pathophysiology.
Aims of the study: This study aimed to amplify IL-1ß gene and detect -5511, rs371339015 and rs376341819 SNPs in gliomassubtypes among Sudanese patients using PCR and Sanger sequencing.
Material and methods: The study was conducted at the National Center for Neurological Sciences during the period from May to September 2022, Khartoum Sudan. From all gliomas patientsduring the above mentioned period, tissue samples were collected and processed for DNA extraction, PCR and further Sanger sequencing
Results: In this study, the most common affected agegroup was 31- 40 years, supratentorial location was seen in more than half of the patients and the astrocytoma grade 1 was detected in 80.9%.
In astrocytoma grades I, the most frequent mutation was C >A in 28.7% and A > C in 19%.
C>T mutation was present in gliomasgrade I, II and III.
Conclusions: In this study, C>T was the most encountered mutation in astrocytoma grades.
Key words: Interleukin-1ß, DNA, PCR
Evaluation of Extractive Value and In-Vitro antimicrobial potential of Curcuma longa using disk diffusion method
Authors: Khan Arif , Jadon Arvind Singh , Bhadauriya Poonam 
Published: December 2022

The efficiency of turmeric fractions, such as petroleum ether, chloroform, benzene, methanol and aqueous were evaluated for their inhibitory effect on clinical and standard strains of pathogenic bacteria and fungus. The methanolic fraction of Curcuma longa rhizome had high potential to inhibit some pathogenic bacteria i.e. S. aureus to a greater degree than other fractions of Curcuma longa. In our study the results show that the different fractions (petroleum ether, methanol etc.) of Curcuma longa rhizome were more effective antimicrobial agents than the crude extract of Curcuma longa. Methanolic extract of curcuma longa was evaluated against gram positive and gram-negative bacteria. The bacteria isolates include Bacillus subtilis and Escherichia coli. Antimicrobial activities were estimated by Well diffusion method and antifungal activity was evaluated against Candida Albicans and Aspergillus Niger. The results were pointed as the methanol extract was more effective on both bacteria and fungus then water also similar effective on both bacteria and fungus but against Aspergillus Nigerit has outstand results.
Keywords: Curcuma longa, Phytochemical, Antimicrobial, Free radical, Scavenging Potential
A Pilot Study of Omalizumab to Treat Severe Allergic Asthma in South Indian Population
Authors: Harshidha D , Dinesh Kumar G , Ektha Promoth Kumar , Dinesh T , Divya T 
Published: December 2022

Background: Asthma is a respiratory disease that affects your lungs. In asthma, airways of the lungs constrict due to swelling and accumulation of mucus. Newer remedies known as targeted therapies have evolved as a result of advancements in medical research, greatly relieving these patients. The biologics used in the severe allergic asthma is Omalizumab.
Purpose: Demonstrating the clinical efficacy of Omalizumab in severe allergic asthma by reducing exacerbation rates and increasing quality of life.
Methods: A single-arm prospective pilot study of omalizumab in severe allergic asthma was conducted in a tertiary care hospital for the duration of one year with the help of Asthma Quality of Life Questionnaire (AQLQ).
Results and discussions: On an initial dose of omalizumab of 150 mg in 2 vials subcutaneously every month for 6 months, among our study population, 45% of the patients had their symptoms improve more than they had with prior medications. Results show that the patient's overall score has improved by nearly 50%. This shows that omalizumab improves the quality of life of severe asthmatic patients.
Conclusion: Patients treated with omalizumab have improved their clinical conditions and quality of life, and it can prevent exacerbations by controlling the severity of the condition.
Keywords: AQLQ, Allergic asthma, Exacerbation, IgE, Omalizumab.
Russia in the Context of the Global Crisis
Authors: Malkov S. Yu. 
Published: December 2022

The article examines the features of the current situation in the world and the existing threats to Russia in its confrontation with the collective West. It is shown that the current global crisis is caused by the change of historical epochs and the transformation of the world system into a qualitatively new state. The old patterns stop working, it’s time to design the future. In these conditions, Russia has a chance to propose its own world order project and become one of the leaders in the new historical reality. But this requires a purposeful and wise policy.Aim. The aim of this article is to analyze the current situation in the world and substantiate Russia’s policy in the current conditions.Tasks. During the research, the following tasks were solved: modeling and forecasting world dynamics in the 21st century, identifying global trends, analyzing the features of the current crisis situation; analysis of the modern confrontation between the collective West and Russia; analysis of the tasks that Russia faces in the short, medium and long term, and justification of ways to solve them.Methods. The methodology for solving these problems is based on the identification of patterns of historical development using modern methods of modeling and forecasting world dynamics, developed at Lomonosov Moscow State University under the guidance of Academician V. A. Sadovnichy.Results. The results of mathematical modeling have shown that humanity is currently moving to a fundamentally new phase of historical development, when the old economic and social technologies (liberal capitalism, classical socialism) no longer work. There is a transition of human society into a new phase state, the shape of which has not yet been determined. In these conditions, we are not talking about forecasting, but about designing the future in new historical conditions. The struggle of world projects begins. Russia’s strategy should be formed on the basis of understanding the specifics of the current situation.Conclusions. The current global crisis creates serious threats to Russia’s development, exacerbates the pressure on it from the collective West. However, at the same time, new opportunities are opening up for Russia: it gets a chance to propose its own world order project and become one of the leaders in the new historical reality. To realize this chance, a purposeful and wise policy is needed. The article suggests a number of measures to implement this policy.
Comparative Analysis of Modern Concepts of Information Warfare
Authors: Vykhodets R. S. , Pantserev K. A. 
Published: December 2022

This study is devoted to the comparative analysis of the subject fields of the main modern concepts of information and psychological warfare.Aim. To identify the features of the subject fields of the main modern concepts of information and psychological warfare.Tasks. To analyze the main modern concepts of information and psychological warfare: information war, network war, network-centric war, mental warfare; determine their essential characteristics and identify the features of subject fields.Methods. During the research, both general scientific (analysis, synthesis, analogy) and special methods were by the authors in order to solve scientific problems: content analysis, comparative analysis, critical discourse analysis.Results. The study showed that the term “information warfare” has appeared in a report commissioned by the US Department of Defense. Further, this concept was actively operated by American military experts involved in the development and planning of various types of military operations. The attitude to this term in scientific circles is ambiguous. In the scientific literature, one can find a large number of definitions explaining this phenomenon, which indicates the ongoing discussions in the scientific world about the sense of the “information war” as the phenomena.Often this term is replaced by the term “information and psychological warfare”, which should be understood as such a relationship between states in which one of the opposing parties, in order to expand its zone of influence and eliminate potential competitors, resorts to active covert influence on the information sphere of its opponent, aimed at creating conditions for making favorable decisions for one or the other state in military, political, economic and other fields.Conclusions. The authors come to the conclusion that the theory of information warfare should be considered as an area of scientific research aimed at understanding the use of advanced technologies in interstate confrontation which causes fundamental changes in the forms, principles and means of conflicts in the information age. Currently, the theory of information warfare has been differentiated and developed in a number of original concepts that focus on various aspects of confrontation in the information environment and the use of ICT in military confrontation.
Pharmaceutical Market of the EAEU: Trends and Prospects of Development
Authors: Vorona A. A. , Gubina M. A. 
Published: December 2022

In modern conditions, international integration in the pharmaceutical industry is becoming a necessary condition for the development of the industry. At the same time, the improvement of medical science and technology is determined by the use of innovative technologies that prevail in the market of medicines. All this determines the relevance of the study. In recent years, the pharmaceutical industry has faced serious challenges: first it was the COVID-19 pandemic, which required a significant mobilization of all scientific and production resources, operational restructuring of many processes, expansion of tools for interaction and partnership at all levels, changes in the regulatory environment, then economic restrictive measures were taken against Russia, which, although not affected drug provision, but they created considerable logistical difficulties for drug manufacturers and generated certain unrest among drug consumers.Aim. To assess the pharmaceutical market of the EAEU, identify emerging problems and outline ways to solve them.Tasks. Consider the capacity of the pharmaceutical market of the EAEU; identify problems arising in the pharmaceutical market of the EAEU; to determine the prospects for the development of the pharmaceutical market of the EAEU.Methods. Statistical analysis of data and synthesis of the results obtained for comparison purposes.Results. A study of trends in the pharmaceutical market was conducted, as a result of which generalizing conclusions were made; problems faced by the market under the influence of uncertainty and risk factors were identified; attempts were made to identify promising directions for the development of the pharmaceutical market of the EAEU.Conclusion. The conducted research makes it possible to identify problematic issues in the development of the pharmaceutical market of the EAEU and outline ways to eliminate them.
Implementation of Lean Manufacturing Methods in Russian Companies
Authors: Smirnov S. A. , Sorokin G. S. 
Published: December 2022

Implementation of lean manufacturing methods is widespread globally. These methods have demonstrated high potential of implementation and gained popularity in many developed, developing and transition economies. Despite the popularity, so far there are few empirical research devoted to the implementation of lean manufacturing in Russia, and this paper partially fills this gap.Aim. The main purpose of the paper is to analyze the spread of lean manufacturing methods, find out the most frequently used practices, describe the industry affiliation of companies and identify problems and obstacles in the implementation of lean manufacturing methods and techniques.Tasks. To achieve the objectives, the quantitative empirical study was conducted on the base of open secondary sources.Methods. The information about the lean projects of 201 companies of different industries was gathered. The data was processed, coded and analyzed.Results. Among findings, we identified that 5S and VSM were the most implementing practices, most of the companies were practicing 3 to 7 lean practices at the same time. Low employee engagement, unfavorable organizational culture and problems of scaling the pilot projects are the most frequent problems in implementing of lean practices.Conclusions. The introduction of lean manufacturing methods remains one of the main direction of production processes improving and labor productivity increasing on Russian enterprises. The study has limitations inherent to research that are based on secondary sources.
The Role of the Digital Transformation in the Fight against Crime at Sea
Authors: Kirilenko V. P. , Alekseev G. V. 
Published: December 2022

Crime control at the sea involves public activities to create a modern security system in seaports, at the territorial sea and the adjacent zone throughout the sea corridors, as well as in the open sea on sea routes with intensive shipping.Aim. Impact assessment of digital transformation on maritime crime control.Tasks. Firstly, to characterize the impact of digital technologies on the nature of pirate attacks and other maritime offenses, which are actual threats to the maritime infrastructure. Secondly, to analyze the impact of modern measures to combat maritime crime on the economy of seaports, shipping companies and other maritime business entities. Thirdly, to demonstrate the role of the seaport administration and private military companies in the fight against offenses at sea.Methods. The study is carried out by formal legal and comparative legal methodology using a review-analytical approach.Results. Data analysis shows that the administrations of seaports are interested in optimizing security costs by creating a convenient digital management system for the coastal infrastructure. Security systems and logistics solutions depend on the effectiveness of digital technologies implemented in the interests of ensuring the safety of navigation. The Convention for the Safety of Human Life at Sea (SOLAS-74/88), supplemented by the International Ship and Port Facility Security Code (ISPS) in 2004, provides for a universal maritime security system, however, the implementation of these standards in a number of regions of the World Ocean is not enough to neutralize coastal criminal threats.Conclusion. In the context of digitalization, measures to combat crime at sea lead to significant costs, as they require complex technological infrastructure on ships and in ports. The norms of the law of the sea aimed at combating piracy and smuggling should be implemented at the national level, taking into account the socio-economic features of the maritime infrastructure development. Since negative economic trends entail an increase in criminal activity, the economic interests of commercial shipping entities should not be sacrificed in the fight against piracy and smuggling.
Forms of Using the Internet to Support Student Activities in Online Classroom Learning in Higher Education
Authors: Mardiana Puja Dikusuma , Sabiruddin Sabiruddin , Gustia Arifah Yenni , Yenis Muhammad , Langputeh Sukree 
Published: December 2022

One of the adjustments made in the learning process during the Covid-19 pandemic was the use of internet media. With the presence of the internet as a source of information, it is very possible for someone to search for and disseminate all science and technology including writing inventions throughout the world easily, quickly, and cheaply. The purpose of this study was to find out how the use of internet media and the role of internet media on student achievement majoring in Islamic Broadcasting Communication at Imam Bonjol State Islamic University, Padang. This study uses a qualitative research method with a phenomenological approach, data sources are taken through in-depth interviews with thirty informants. All data were analyzed thematically using the Miles and Huberman technique. Mass Communication Theory which is used in this research is Uses and Gratificition Theory. The results of the study found five activities carried out by students on the internet to support lectures: (i) looking for assignment references through journals, (ii) reading online news, (iii) watching Youtube tutorials, (iv) searching Google, Blogs, Web, (v) discuss and learn together like in a WhatsApp group. Furthermore, overall, the informants stated that the use of the internet network could support their learning achievement in higher education.
Kesantunan Berbahasa dalam Novel Resign! karya Almira Bastari
Authors: Ningrum Indah Surya , Saptomo Sri Wahono , Sudiatmi Titik 
Published: December 2022

The purpose of this study is describe the politeness of language contained in the novel Resign! by Almira Bastari. The method used is descriptive qualitative method. The data used is a piece of dialogue from a character that is suspected to contain compliance and violation of the maxim of politeness in language. The source of data in this study is the dialogue of the characters in the novel. Data collection techniques used are library techniques as basic techniques and reading and note-taking techniques as advanced techniques. The data analysis technique used is descriptive analysis technique. The results showed that there was compliance and violation of the maxim of politeness in the novel Resign!. The politeness maxims found are (1) tact maxim, (2) generosity maxim, (3) approbation maxim, (4) modesty maxim, (5) agreement maxim, and (6) sympathy maxim. Meanwhile, the violation of the maxim of politeness in the novel Resign! consists of, (1) tact maxim, (2) generosity maxim, (3) approbation maxim, (4) modesty maxim, and (5) agreement maxim.
Influence of product complexity on sustainable development of industrial enterprises
Authors: Popov Nikita Evgen'evich 
Published: December 2022

The article considers the influence of product complexity (expansion of the product range for ensuring
a balanced product portfolio capable of meeting consumer requirements, used technological equipment and raw materials components characterized by non-standard characteristics, complexity of technological processes, etc.) on operational efficiency (production time, cost, supply chain, effective inventory management, etc.) and, as a consequence, on ensuring the sustainable development of industrial enterprises, taking into account the peculiarities of production and economic activity. The concepts of product complexity and operational efficiency are studied in detail. It is demonstrated that the product complexity has a stable relationship with the increasing costs, time spent on the produced unit, providing the warehouse balance of finished products, amount of labor, downtime of the main technological equipment associated with the production of a large assortment of goods. Relationship between the increased complexity of the product and its quality is less pronounced. Control over the quality indicators is important at all phases of the production process. The negative influence of the product complexity on most performance indicators is a phenomenon existing in all industries, which is a warning to manufacturers expanding the product line. The criteria for measuring the complexity of products were identified. A methodological approach is presented that allows the use of integrated complexity assessment technologies including the use of analysis tools from other scientific fields. It has been inferred that further investigating the solutions of the problem is reliable on the basis of different approaches.
Occult Hepatitis B Infection in Kidney Transplant Patients
Authors: Paramita Ida Ayu Pradnya , Wibawa I Dewa Nyoman 
Published: December 2022

Occult hepatitis B infection (OBI) is still a topic of debate worldwide. It is defined as the presence of hepatitis B virus (HBV) DNA in serum and/or liver from HBsAg-negative subjects. OBI may lead to the development of cirrhosis and hepatocellular carcinoma. It continues to present several unique challenges in organ transplantation despite the availability of an effective vaccine to prevent HBV infection and the introduction of oral therapy to treat HBV infection. HBV reactivation following organ transplantation can occur even in recipients with absent hepatitis B surface antigen and remains an important cause of morbidity and mortality. Concerning OBI complications, the screening of HBV DNA by the highly sensitive molecular means should be implemented for both recipients of organ transplant and organ transplant donors especially in highly endemic areas of HBV. In the era of potent antivirals and with evolving knowledge, HBsAg (+) renal transplant candidates and recipients can be monitored and successfully treated. Kidney organs from HBsAg-negative and anti-HBc–positive donors should be considered for transplant candidates after weighing the risk-benefit ratio. All transplant candidates should receive HBV vaccination if they are not immune to facilitate receipt of an organ from a donor with anti-HBc seropositivity.
Hubungan Albuminuria dan Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus Tipe 2 yang Tidak Terkontrol
Authors: Parinding Vinny Vania , Ilmiawan Muhammad In'am , Fitrianingrum Iit , Trianto Heru Fajar , Mardhia Mardhia 
Published: December 2022

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Patients with diabetes mellitus require optimal glycemic control. Poorly controlled diabetes mellitus is at risk for complications, such as diabetic nephropathy. Diabetic nephropathy is characterized by albuminuria and can lead to decreased Glomerular Filtration Rate (GFR). Objectives: To determined the relationship between albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus. Methods: This research was conducted at the Pontianak Branch of Prodia Health Clinic Laboratory in March 2021, using secondary data of laboratory examination results from DM patients in the 2020 period. This research was observational analytics with a cross-sectional approach. The number of samples that comply with the research criteria was 273 people. Bivariate analysis using Spearman’s correlation test. Results: Spearman's correlation test results showed significance (p=0.001) and correlation coefficient (r=0.209). Conclusion: Albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus are significantly and positively correlated.Keywords: albuminuria, poorly controlled type 2 diabetes mellitus, glomerular filtration rate