bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative transcriptome analysis reveals sex bias in expression patterns of genes related to sex steroids and immunity in the skin of spinyhead croaker Collichthys lucidus
Authors: Zhou Li , Liu Fujiang , Chen Junnan , Yang Ran , Li Jinshou , Wang Zhiyong , Cai Mingyi 
Published: April 2023

AbstractFish skin is the first barrier against external invasion, and also an important interface for communication between males and females during reproduction. Nonetheless, sexual dimorphism in the physiology of fish skins is still poorly understood. Herein, transcriptomes of skin were comparatively analysed between males and females in spinyhead croaker, Collichthys lucidus. Totally, 170 differentially expressed genes (DEG) were detected, including 79 female‐biased genes and 91 male‐biased genes. Gene ontology (GO) annotation items of the DEGs were mainly enriched in biological process items (86.2%), including regulation of biological processes, responses to chemical and biological stimuli, transport and secretion, movement, immune response, tissue development, etc. In KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis, the male‐biased genes were enriched in pathways including those related to immunity such as the TNF signalling pathway and IL‐17 signalling pathway, whereas the female‐biased genes were enriched in pathways including those related to female steroids such as ovarian steroidogenesis and oestrogen signalling pathway. In addition, odf3 was found to be a male‐specific expression gene, being a candidate marker for phenotypic sex. Thus, the sexual difference in gene expression in fish skin in spawning season was uncovered by transcriptome analysis for the first time, providing new insights into sexual dimorphism in the physiology and functions of fish skin.
The origin and compositions of melt inclusions in an Al2SiO5‐free paragneiss from the Namche Barwa Complex in the Eastern Himalayan Syntaxis
Authors: Liu Qiang , Liu Penglei , Li Xin , Zhang Junfeng 
Published: April 2023

AbstractMelt inclusions (MIs) in high‐temperature metamorphic rocks provide a unique window into crustal anatexis in collisional orogenic belts and have been widely used to characterize compositions of anatectic melts as well as melting mechanisms. In this study, MIs hosted by peritectic garnet were for the first time identified in an Al2SiO5‐free graywacke‐type paragneiss from the Namche Barwa Complex, the Eastern Himalaya, Southeast Tibet. These MIs occur as nanogranites in the rims of porphyroblastic garnet, exhibit negative crystal shapes with an average diameter of ~12 μm and consist of a mineral assemblage of biotite + quartz + plagioclase + K‐feldspar ± muscovite. Re‐homogenization experiments of these nanogranites were conducted at a pressure of 1.5 GPa and temperatures of 800°C, 850°C and 900°C and produced homogeneous glasses at 850°C. The homogenized glasses are strongly peraluminous and calc‐alkalic in composition, with 66.43–71.31 wt.% SiO2, 12.64–15.06 wt.% Al2O3, high alkaline (5.41–7.22 wt.%) and low ferromagnesian (2.72–4.46 wt.%) contents. They are lower in silica and CaO but higher in K2O compared with MI produced by fluid‐present melting of metasedimentary rocks, thus indicating fluid‐absent melting. These glasses are also characterized by enrichment of large ion lithophile elements (particularly Cs and Rb), depletion of Ba and Sr, low contents of light rare earth elements (3.6 to 33.7 ppm), high Rb/Sr ratios (6.19–37.3) and low Nb/Ta ratios (2.55–18.7). In combination with phase equilibrium modelling, these compositional features suggest that a sequential dehydration melting of muscovite and biotite was responsible for the production of MI during prograde metamorphism of the studied paragneiss. By compiling MI data published in the literature, we show that dehydration melting of metasedimentary rocks from the Himalayan orogen can produce initial melts with various peraluminous and granitic compositions.
Relations between youths' community violence exposure and their physical aggression: The protective role of adults
Authors: Coleman Jasmine N. , Mehari Krista , Farrell Albert D. 
Published: April 2023

AbstractThe purpose of this study was to examine whether adults moderated the relations between youths' community violence exposure and subsequent physical aggression. Participants were 2575 middle school students (Mage = 12.3, SD = 1.00; 52% female) in the southeastern U.S. who completed surveys collected in the fall, winter, spring, and summer. The sample was predominantly African American (72%). High adult support was associated with weaker relations between exposure to violence in the fall and aggression in the winter among male adolescents. High adult support was related to weaker relations between victimization in the fall and aggression in the winter among female adolescents. Strategies promoting supportive adult relationships may benefit male adolescents by buffering the adverse impact of community violence exposure.
MRI‐Related Risk Factors for Distal Radioulnar Joint Instability
Authors: He Xin , Chen Fei , Li Jian , Dong Xiaoman , Zhang Hanzhi , Guo Lin 
Published: April 2023

ObjectiveInstability of the dorsal radioulnar ligament (DRUL) is caused by multiple factors from bony and soft tissue structures. Studies of DRUJ instability based on MRI have rarely been reported. This study aims to investigate related instability factors in the distal radioulnar joint (DRUJ) after trauma based on MRI imaging.MethodsThe MRI imaging was performed on 121 post‐traumatic patients with or without DRUJ instability from April 2021 to April 2022. All patients demonstrated pain or attenuated wrist ligamentous tissue quality with physical examination. The interesting variables, including age, sex, the distal radioulnar transverse shape, the triangular fibrocartilage complex (TFCC), DRUL, the volar radioulnar ligament (VRUL), distal interosseus membrane (DIOM), the extensor carpi ulnaris (ECU), and pronator quadratus (PQ), were analyzed using univariable and multivariable logistic regression model. The different variables were compared in radar plots and bar chart.ResultsAn average age of 121 patients was 42.16 ± 16.07 years. The 50.4% DRUJ instability existed in all patients and the distal oblique bundle (DOB) presented in 20.7% of patients. The TFCC (p = 0.03), present DIOM (p = 0.001), and PQ (p = 0.006) were identified to be significant in final multivariable logistic model. The percentage of patients with ligament injuries were general higher in DRUJ instability group. The patients with absent DIOM had a higher rate in DRUJ instability, TFCC, and ECU injury. There was higher stability in shape of C‐type, intact TFCC, and present DIOM.ConclusionDRUJ instability is closely associated with TFCC, DIOM, and PQ. It could provide a potential for early detection of potential instability risk and taking necessary preventive measures.
Intra‐Operative Neurophysiological Monitoring in Patients with Thoracic Spinal Stenosis: Its Feasibility and High‐Risk Factors for New Neurological Deficit
Authors: Liu Wanyou , Li Yinkun , Qiu Junyin , Shi Benlong , Liu Zhen , Sun Xu , Zhu Zezhang , Qiu Yong 
Published: April 2023

ObjectiveConsidering the high risk of postoperative neurological complications for patients with thoracic spinal stenosis (TSS), intra‐operative neurophysiological monitoring (IONM) has been used for detecting possible iatrogenic injury timely. However, the IONM waveforms are often unreliable. This article is designed to determine the test performance of somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) during surgical thoracic decompression in patients with TSS, and to investigate the risk factors associated with deteriorated neurologic function at immediate postoperation.MethodsPatients undergoing posterior spinal fusion from February 2009 to December 2020 were retrospectively reviewed. Patients were divided into the deteriorated neurologic function (DNF) group and the improved/intact neurological function (INF) group based on the postoperative neurological status. Demographic parameters such as gender, age, height, weight, etiology and IONM data were compared between groups. Demographics and IONM data between DNF and INF groups were compared by independent t or nonparametric tests. The incidence of abnormal SEP was analyzed by Chi‐square test.ResultsA total of 108 patients (63 males, 45 females) with an average age of 53.5 ± 14.0 years were included. The SEP and MEP records were available in 94 and 98 patients, with the overall success rates being 87.0% and 90.7%, respectively. The sensibilities and specificities were 100% and 88.2% for SEP, 100% and 98.8% for MEP, respectively. There were 17 patients in DNF group and 91 patients in INF group. High weight (79.1 ± 14.6 vs 69.7 ± 15.7 kg, P = 0.024), high inter‐side difference of MEP amplitude (899.1 ± 997.5 vs 492.3 ± 512.4 μV, P = 0.013) and high incidence of abnormal SEP (94.1% vs 64.8%, P = 0.024) were observed in the DNF group. Fourteen (82.4%) patients in the DNF group showed improvement in neurological status during follow‐up.ConclusionsThe overall success rates were 87.0% for SEP and 90.7% for MEP in patients with TSS.
Enabling boundary spanners in public–private collaboration: The impact of support and role autonomy on reducing role stress
Authors: Satheesh Shreya Anna , van Meerkerk Ingmar , Verweij Stefan , Busscher Tim , Arts Jos 
Published: April 2023

AbstractBoundary spanners are pivotal in developing effective public–private collaboration in public infrastructure projects. As boundary spanners have to account for different interests, perspectives, and ways of working in public–private collaborations, engaging in boundary‐spanning activities often comes with role stress, which can negatively impact their job performance. However, despite the significant levels of role stress associated with boundary spanning, there is a dearth of empirical studies on the role stress of boundary spanning public managers and how it can be reduced. In this study, we empirically investigate the reciprocal relationship between role stressors and boundary spanning and test if supporting organizational conditions can alleviate role stressors. The findings show that especially role conflict is detrimental for boundary‐spanning activities. We further find that top‐management support can diminish both role conflict and role ambiguity and that co‐worker support can help in reducing the role ambiguity of boundary spanning public managers.
Perioperative hypertension and anesthetic management in patients undergoing resection of neuroblastoma
Authors: Liu Jia , Zurakowski David , Weldon Christopher , Umaretiya Puja , Holzman Robert , Lin Yuan‐Chi 
Published: April 2023

AbstractIntroductionNeuroblastoma is the most common extracranial pediatric tumor, accounting for 5–8% of all childhood cancers. Neuroblastomas arise from catecholamine‐secreting neural crest cells and their metabolites, vanillylmandelic acid and homovanillic acid, that are readily detected in urine. Although rarely seen in clinical practice, case reports exist documenting severe intraoperative hypertension. However, data on the incidence of intraoperative hypertension are lacking.MethodsThis report is a single‐center retrospective review of patients with neuroblastoma who underwent surgical resection (n = 102) at Boston Children's Hospital from July 1, 2012 to February 28, 2021. Significant intraoperative hypertension was defined as maximum systolic blood pressure greater than 95th percentile +12 mmHg based on normative blood pressure data. Statistical analysis was performed using Fisher's exact test, Wilcoxon rank‐sum test, and logistic regression.ResultsThe overall incidence of intraoperative hypertension was 13% (n = 13/102). Higher American Society of Anesthesiologists (ASA) physical status was associated with intraoperative hypertension. Antihypertensive medications were administered intraoperatively in 9% of cases (n = 9), and the use was significantly associated with intraoperative hypertension. Of patients with preoperative urine catecholamine data (n = 82), all 10 patients who had intraoperative hypertension were noted to have elevated preoperative urine catecholamines. Intraoperative hypertension was not associated with postoperative hypertension, postoperative hypotension, or increased intensive care unit length of stay.Discussion/ConclusionIntraoperative hypertension in patients with neuroblastoma remains a relatively uncommon occurrence; however, it does occur at a frequency higher than previously described. While intraoperative hypertension is associated with an increased use of antihypertensive medications in the operating room, it is not associated with adverse perioperative outcomes.
Mitigating Extra‐Firm Risk Environments – The Case of Turkish Firms in Germany
Authors: Völlers Philip 
Published: April 2023

AbstractRecent studies claim that the extra‐firm environment as a causal driver for configuration processes in global production networks is understudied. The case of Turkish cross‐border foreign direct investment into Germany is analysed to facilitate a better understanding of how transnationally embedded firms perceive and respond to extra‐firm risk environments. The global production network lens frames the discussion, applying the analytical categories of embeddedness, risk and value. Qualitative interviews with 15 Turkish firm managers in Germany and 24 experts in the field of Turkish‐German business relations were conducted. The analysis shows that transnationally embedded Turkish firms respond to extra‐firm risks by deepening their territorial embeddedness in the host country. While mimicking domestic firms on the level of societal embeddedness, Turkish firms dissociate from risk narratives related to their home country and valorise their association with the German embeddedness context on the firm and network level.
PRIMING OF CHIKENS WITH LIVE AND INACTIVATED IBС VACCINE
Authors: Babak V.A. , Gusev A.A. 
Published: April 2023

The research gives the results of the experiments to study the effect of priming the chickens with a live and inactivated vaccine against the IBC virus, and subsequent immunization with a live vaccine. The research demonstrates the results of the study of optimal schemes of birds’ immunization with live and inactivated vaccines, when the greatest specific effect is achieved.
It has been established that priming chickens that do not contain antibodies against IBC with both live and inactivated vaccines causes the formation of intense immunity in them, which indicates a mature immune system capable of actively responding to a foreign antigen in the first days of life.
Priming chickens with a live vaccine based on the background of maternal antibodies is not accompanied by the synthesis of antibodies, unlike priming with an inactivated vaccine, which leads to the formation of insignificant humoral immunity.
Vaccination chickens containing maternal antibodies with live vaccine, primed with both live and inactivated vaccine depends on the content of specific antibodies in their body and is more effective when the level of antibodies in their body is low.
Individual Solutions in Motor Learning: Combining Different Analyses
Authors: Profeta Vitor Leandro da Silva , Campos Claisyellen Silva 
Published: April 2023

Different individuals learn different solutions to the same perceptual-motor task regardless of the fact that they may undergo the same practice conditions. In the current study, we characterized individual solutions to a perceptual-motor task. Eighteen self-declared right-handed participants were requested to intercept a moving target controlling a virtual ball using a computer mouse. Target speed varied across trials. Participants visited the lab 2 days in a row. They practiced 250 trials on Day 1 and 50 trials on Day 2. We assessed participants’ preferred speed and maximum speed on both days. We combined a qualitative description of solutions on the task space and the quantitative growth curve analysis to address individual differences. Results indicated an overall trend to increase the ball release speed to handle the task constraints. Moreover, the local shape of the solution manifold constrained individuals’ solutions. Contrary to our expectations, neither individual preferred speed nor individual maximum speed improved model fit.
Providing Oxygen during Intubation in the NICU Trial (POINT): study protocol for a randomised controlled trial in the neonatal intensive care unit in the USA
Authors: Herrick Heidi M , O'Reilly Mackenzie , Lee Sura , Wildenhain Paul , Napolitano Natalie , Shults Justine , Nishisaki Akira , Foglia Elizabeth E 
Published: April 2023

IntroductionNearly half of neonatal intubations are complicated by severe desaturation (≥20% decline in pulse oximetry saturation (SpO2)). Apnoeic oxygenation prevents or delays desaturation during intubation in adults and older children. Emerging data show mixed results for apnoeic oxygenation using high-flow nasal cannula (NC) during neonatal intubation. The study objective is to determine among infants ≥28 weeks’ corrected gestational age (cGA) who undergo intubation in the neonatal intensive care unit (NICU) whether apnoeic oxygenation with a regular low-flow NC, compared with standard of care (no additional respiratory support), reduces the magnitude of SpO2decline during intubation.Methods and analysisThis is a multicentre, prospective, unblinded, pilot randomised controlled trial in infants ≥28 weeks’ cGA who undergo premedicated (including paralytic) intubation in the NICU. The trial will recruit 120 infants, 10 in the run-in phase and 110 in the randomisation phase, at two tertiary care hospitals. Parental consent will be obtained for eligible patients prior to intubation. Patients will be randomised to 6 L NC 100% oxygen versus standard of care (no respiratory support) at time of intubation. The primary outcome is magnitude of oxygen desaturation during intubation. Secondary outcomes include additional efficacy, safety and feasibility outcomes. Ascertainment of the primary outcome is performed blinded to intervention arm. Intention-to-treat analyses will be conducted to compare outcomes between treatment arms. Two planned subgroup analyses will explore the influence of first provider intubation competence and patients’ baseline lung disease using pre-intubation respiratory support as a proxy.Ethics and disseminationThe Institutional Review Boards at the Children’s Hospital of Philadelphia and the University of Pennsylvania have approved the study. Upon completion of the trial, we intend to submit our primary results to a peer review forum after which we plan to publish our results in a peer-reviewed paediatric journal.Trial registration numberClinicalTrials.gov Registry (NCT05451953).
Integrated approach to cardiovascular disease in people experiencing homelessness: a qualitative study
Authors: Bark Pippa , Ramasawmy Mel , Hayward Andrew , Luchenski Serena , Aldridge Robert , Burridge Stan , Banerjee Amitava 
Published: April 2023

BackgroundHomelessness is associated with an increased risk of cardiovascular disease (CVD), beyond impact of socioeconomic status. CVD is preventable and treatable, though barriers to interventions exist for people experiencing homelessness. Those with lived experience of homelessness and health professionals with relevant expertise can help to understand and address these barriers.ObjectivesTo understand, and make recommendations to improve, CVD care in homeless populations through lived and professional expertise.MethodFour focus groups were conducted in March–July 2019. Three groups included people currently or previously experiencing homelessness, each attended by a cardiologist (AB), a health services researcher (PB) and an ‘expert by experience’ (SB) who coordinated participants. One group included multidisciplinary health and social care professionals in and around London to explore solutions.ParticipantsThe three groups included 16 men and 9 women, aged 20–60 years, of whom 24 were homeless and currently living in hostels, and 1 rough sleeper. At least 14 discussed sleeping rough at some point.ResultsParticipants were aware of CVD risks and relevance of healthy habits but identified barriers to prevention and health access, starting with disorientation affecting planning and self-care, lack of facilities for food, hygiene and exercise, and experiences of discrimination.ConclusionsCVD care for those experiencing homelessness should account for fundamental problems of the environment, be codesigned with service users and cover key principles: flexibility, public and staff education, integration of support and advocacy for health service rights.
Dependence of the probability of escape on the Jacobi constant in the N-body ring problem without central body
Authors: Belgharbi Ibrahim , Navarro Juan F. 
Published: April 2023

AbstractIn this work, we perform a numerical exploration of the escape in the N-body ring problem in absence of a central body, for $$4\le N\le 9$$

4
≤
N
≤
9

and ten values of the Jacobi constant. We show how the probability of escape per interval of time varies as a function of the Jacobi constant, finding that, for values of the Jacobi constant smaller than a certain limit value, the probability of escape from the system tends to decrease with time. However, if we consider values of the Jacobi constant larger than this limit value, the probability of escape grows with time, for times of escape smaller than 100 units of time.
Multi-criteria Optimization of Real-time DAGs on Heterogeneous Platforms under P-EDF
Authors: Cucinotta Tommaso , Amory Alexandre , Ara Gabriele , Paladino Francesco , Natale Marco Di 
Published: April 2023

This article tackles the problem of optimal placement of complex real-time embedded applications on heterogeneous platforms. Applications are composed of directed acyclic graphs of tasks, with each directed-acyclic-graph (DAG) having a minimum inter-arrival period for its activation requests and an end-to-end deadline within which all of the computations need to terminate since each activation. The platforms of interest are heterogeneous power-aware multi-core platforms with Dynamic Voltage and Frequency Scaling (DVFS) capabilities, including big.LITTLE Arm architectures and platforms with GPU or FPGA hardware accelerators with Dynamic Partial Reconfiguration capabilities. Tasks can be deployed on CPUs using partitioned EDF-based scheduling. Additionally, some of the tasks may have an alternate implementation available for one of the accelerators on the target platform, which are assumed to serve requests in non-preemptive FIFO order. The system can be optimized by minimizing power consumption, respecting precise timing constraints, maximizing the applications’ slack, respecting given power consumption constraints, or even a combination of these, in a multi-objective formulation.
We propose an off-line optimization of the mentioned problem based on mixed-integer quadratic constraint programming (MIQCP). The optimization provides the DVFS configuration of all the CPUs (or accelerators) capable of frequency switching and the placement to be followed by each task in the DAGs, including the software-vs.-hardware implementation choice for tasks that can be hardware accelerated. For relatively big problems, we developed heuristic solvers capable of providing suboptimal solutions in a significantly reduced time compared to the MIQCP strategy, thus widening the applicability of the proposed framework.
We validate the approach by running a set of randomly generated DAGs on Linux under SCHED_DEADLINE, deployed onto two real boards, one with Arm big.LITTLE architecture, the other with FPGA acceleration, verifying that the experimental runs meet the theoretical expectations in terms of timing and power optimization goals.