bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative prediction of pancreatic neuroendocrine tumor grade based on 68Ga-DOTATATE PET/CT
Authors: Ma Jiao , Wang Xiaoyong , Tang Mingsong , Zhang Chunyin 
Published: September 2023

Abstract
Objective
To establish a prediction model for preoperatively predicting grade 1 and grade 2/3 tumors in patients with pancreatic neuroendocrine tumors (PNETs) based on 68Ga-DOTATATE PET/CT.

Methods
Clinical data of 41 patients with PNETs were included in this study. According to the pathological results, they were divided into grade 1 and grade 2/3. 68Ga-DOTATATE PET/CT images were collected within one month before surgery. The clinical risk factors and significant radiological features were filtered, and a clinical predictive model based on these clinical and radiological features was established. 3D slicer was used to extracted 107 radiomic features from the region of interest (ROI) of 68Ga-dotata PET/CT images. The Pearson correlation coefficient (PCC), recursive feature elimination (REF) based five-fold cross validation were adopted for the radiomic feature selection, and a radiomic score was computed subsequently. The comprehensive model combining the clinical risk factors and the rad-score was established as well as the nomogram. The performance of above clinical model and comprehensive model were evaluated and compared.

Results
Adjacent organ invasion, N staging, and M staging were the risk factors for PNET grading (p < 0.05). 12 optimal radiomic features (3 PET radiomic features, 9 CT radiomic features) were screen out. The clinical predictive model achieved an area under the curve (AUC) of 0.785. The comprehensive model has better predictive performance (AUC = 0.953).

Conclusion
We proposed a comprehensive nomogram model based on 68Ga-DOTATATE PET/CT to predict grade 1 and grade 2/3 of PNETs and assist personalized clinical diagnosis and treatment plans for patients with PNETs.
Postmortem redistribution of drugs: a literature review
Authors: Abdelaal Ghadeer M. M. , Hegazy Nagah I. , Etewa Rasha L. , Elmesallamy Ghada E. A. 
Published: September 2023

Abstract
Postmortem drug analysis is crucial in identifying the potential cause and manner of death. However, it is threatened by a significant phenomenon called postmortem redistribution (PMR), which refers to the alterations in drug levels occurring after death. This review aims to describe the PMR phenomenon, the mechanisms involved in the PMR of drugs, the various methods used to predict it, and various artifacts of postmortem drug concentrations. Several mechanisms, including passive diffusion from solid organs that act as drug reservoirs to the surrounding tissues, cadaveric changes after death (e.g., cell death, blood coagulation, hypostasis, and movements), and the putrefactive process, can result in artifacts of postmortem drug concentrations. The drug’s chemical and pharmacokinetic properties (such as acidic/basic properties, lipophilicity, protein binding, high volume of distribution, and residual metabolic activity) are additional factors. Several markers, including cardiac blood-to-peripheral blood ratio (C/P), liver-to-peripheral blood ratio (L/P), amino acid markers such as methionine, quantitative structure–activity relationship (QSAR) approach, and F factor, have been proposed for interpreting the liability of drugs to PMR. Several artifacts may affect the reliability of postmortem drug analysis. Peripheral blood is preferred for postmortem drug sample collection. Numerous laboratories evaluate the redistribution potential of drugs after death using the C/P concentration ratio. Nevertheless, the L/P concentration ratio is proposed to be a more reliable marker for PMR determination.
Whole-brain Optical Imaging: A Powerful Tool for Precise Brain Mapping at the Mesoscopic Level
Authors: Jiang Tao , Gong Hui , Yuan Jing 
Published: September 2023

AbstractThe mammalian brain is a highly complex network that consists of millions to billions of densely-interconnected neurons. Precise dissection of neural circuits at the mesoscopic level can provide important structural information for understanding the brain. Optical approaches can achieve submicron lateral resolution and achieve “optical sectioning” by a variety of means, which has the natural advantage of allowing the observation of neural circuits at the mesoscopic level. Automated whole-brain optical imaging methods based on tissue clearing or histological sectioning surpass the limitation of optical imaging depth in biological tissues and can provide delicate structural information in a large volume of tissues. Combined with various fluorescent labeling techniques, whole-brain optical imaging methods have shown great potential in the brain-wide quantitative profiling of cells, circuits, and blood vessels. In this review, we summarize the principles and implementations of various whole-brain optical imaging methods and provide some concepts regarding their future development.
What Mindfulness, and for Whom? And Why Might it Work?
Authors: Sedlmeier Peter 
Published: September 2023

AbstractThis comment on “Mindfulness for global public health: Critical analysis and agenda” by Doug Oman focuses on the difficulties associated with the current use and understanding of the term mindfulness. In particular, I argue that the current lack of agreement on what mindfulness practice is, or, perhaps more realistically, what mindfulness practices are, and how their effects can be explained might jeopardize such an integration process in the long run. In the literature, one can find widely differing conceptions of what constitutes a mindfulness practice. Moreover, there is clear evidence that different mindfulness practices can yield quite different effects. This holds for the comparison of “mindfulness packages” but also for comparisons of single components of these packages, and for incremental combinations of components. There is also strong evidence that mindfulness practices do not work equally well for different purposes and different people. These differential effects need to be elaborated and explained. Unfortunately, theoretical models for mindfulness practices are also still quite heterogeneous. As a first step, researchers and practitioners could be very specific about what they mean by mindfulness practice or even use alternative terms for different practices. Moreover, they could stay open to alternative forms of meditation and put as much theory as possible into their research to eventually find out when, how, and why specific mindfulness practices (and packages thereof) work and for whom.
Reuse of Steel in the Construction Industry: Challenges and Opportunities
Authors: Kanyilmaz Alper , Birhane Mussie , Fishwick Roy , del Castillo Carlos 
Published: September 2023

AbstractThe construction industry plays a critical role in tackling the challenges of climate change, carbon emissions, and resource consumption. To achieve a low-emission built environment, urgent action is required to reduce the carbon emissions associated with steel production and construction processes. Reusing structural steel elements could make a significant impact in this direction, but there are five key challenges to overcome: limited material availability, maximizing different reusable materials from demolition, lack of adequate design rules and standards, high upfront costs and overlooked carbon impact of the demolition prior to construction, and the need to engage and coordinate the complete construction ecosystem. This article described these barriers and proposed solutions to them by leveraging the digital technologies and artificial intelligence. The proposed solutions aim to promote reuse practices, facilitate the development of certification and regulation for reuse, and minimize the environmental impact of steel construction. The solutions explored here can also be extended to other construction materials.
The Interrelation Between Emotional Impulsivity, Craving, and Symptoms Severity in Behavioral Addictions and Related Conditions: a Theory-Driven Systematic Review
Authors: López-Guerrero José , Navas Juan F. , Perales José C. , Rivero Francisco J. , Muela Ismael 
Published: September 2023

Abstract
Purpose of Review
Here, we systematically review all available evidence on the triadic relationship between positive and negative urgency, craving, and severity of symptoms of candidate behavioral addictions.

Recent Findings
Current theoretical models attribute a central importance to craving in the chronification and prognosis of behavioral addictions and other problematic non-substance-related behavioral patterns. Craving, in turn, has been convincingly shown to be an affect-laden state, and its control can be conceptualized as partially resulting from emotion regulation mechanisms. However, some gaps remain: first, there is no consensus on the predominantly appetitive or aversive nature of craving; and, second, although positive and negative urgency have been proposed as proxies to incidental emotion regulation mechanisms, their direct or indirect role in craving regulation and severity of problematic behaviors is still poorly known.

Summary
According to our results, craving emerges as a central construct, partially resulting from emotion dysregulation as assessed by urgency. The preponderance of positive urgency shown by most studies in this review also reinforces the view of positive emotions as a ‘trojan horse’ in addictive processes. Negative urgency, in turn, seems to be a complication factor that could underlie gambling addiction and other related mental health conditions. Most studies, however, are about gambling behavior, with the few studies in other domains precluding firm conclusions about the differences or similarities between them.
Food Addiction and Impulsivity in Clinical Populations by Gender: a Systematic Review
Authors: Gaspar-Pérez Anahí , Paslakis Georgios , Rosinska Magda , Munguía Lucero , Jiménez-Murcia Susana , Szilágyi Anna , Miranda-Olivos Romina , Camacho-Barcia Lucia , Reque Cristina Ballero , Pászthy Bea , Fernández-Aranda Fernando 
Published: September 2023

Abstract
Purpose of Review
Food addiction (FA) has been found to be associated with impulsivity, mainly urgency (negative and positive) and lack of perseverance. The present systematic review aimed to identify differences in impulsivity by gender and current implications of treatment regarding FA and impulsivity in clinical populations. The search was conducted in PubMed, Scopus, and Web of Science (WOS) databases, using the following search terms: “food addiction” and “impuls*.” Studies were included if they were written in English, had an observational design (e.g., cross-sectional, longitudinal, case-control), and used a quantitative methodology, without a limited search period to avoid selection bias.

Recent Findings
We included twenty-nine articles that aimed to examine whether there is a relationship between FA and impulsivity in clinical populations. Looking at gender differences, attentional and motor impulsivity were found to be related to FA in samples of women with obesity, whereas in the only study in a sample of men with obesity, cognitive and non-planning impulsivity appeared to be more associated with FA. Moreover, we identified three studies on the effects of interventions which included motivational, psychosocial, nutritional, and mindfulness components to address impulsivity and FA in cohorts with overweight/obesity and with substance use disorder (SUD). While some studies reported decreased levels of impulsivity, in other studies only FA decreased, and only one study showed significant changes in both FA and impulsivity after treatment.

Summary
Further research is needed to better understand the association between impulsivity and FA. Specifically, more studies with male populations could provide further evidence on how to better tailor treatment designs.
Optimization of castor bean (Ricinus communis L.) cultivation methods using biostimulants in an arid climate
Authors: Esmaeilian Yaser , Babaeian Mahdi , Caballero-Calvo Andrés 
Published: September 2023

AbstractIn arid areas, low soil fertility, an imbalance of nutrients, and the inability of crops to absorb some nutrients are among the main constraints on crop production. The use of biological fertilizers and biostimulants can be a suitable solution. A 2-year field experiment was conducted as a factorial experiment based on a randomized complete block design with three replications to study the response of castor bean to arbuscular mycorrhizal fungi (AMF) and amino acid biostimulant (AAB) (foliar, soil, and combined application methods). Findings showed that plants inoculated with AMF had better performance: the biological and seed yields were increased by an average of 20.9 and 26.4% over the 2 years of the experiment. The yield components showed a 14.0 to 18.6% increase, and the water productivity (WP) was improved by 13.9%. The seed oil content was increased by 5.1%: linoleic acid, an oil fatty acid, showed the highest response, with an increase of 10.0%. Among the AAB treatments, the combined application method (CAM) brought the best results. The highest increases in biological and seed yields (68.4 and 63.2%, respectively) were obtained from the CAM treatment. The WP was improved by 67.8% and the seed oil content showed an increase of 9.4%. Among the fatty acids, the highest increase (24.4%) belonged to linoleic acid. The results show a positive and significant response of castor beans to biostimulants, which indicates that replacing chemicals with biological fertilizers could be a promising approach to the cultivation of castor beans in arid climates.
Large simplicial complexes: universality, randomness, and ampleness
Authors: Farber Michael 
Published: September 2023

AbstractThe paper surveys recent progress in understanding geometric, topological and combinatorial properties of large simplicial complexes, focusing mainly on ampleness, connectivity and universality (Even-Zohar et al. in Eur J Math 8(1):1–32, 2022; Farber and Mead in Topol Appl 272(22):107065, 2020; Farber et al. in J Appl Comput Topol 5(2):339–356, 2021). In the first part of the paper we concentrate on r-ample simplicial complexes which are high dimensional analogues of the r-e.c. graphs introduced originally by Erdős and Rényi (Acta Math Acad Sci Hungar 14:295–315, 1963), see also Bonato (Contrib Discrete Math 4(1):40–53, 2009). The class of r-ample complexes is useful for applications since these complexes allow extensions of subcomplexes of certain type in all possible ways; besides, r-ample complexes exhibit remarkable robustness properties. We discuss results about the existence of r-ample complexes and describe their probabilistic and deterministic constructions. The properties of random simplicial complexes in medial regime (Farber and Mead 2020) are important for this discussion since these complexes are ample, in certain range. We prove that the topological complexity of a random simplicial complex in the medial regime satisfies $$\textsf{TC}(X)\le 4$$

TC
(
X
)
≤
4

, with probability tending to 1 as $$n\rightarrow \infty $$

n
→
∞

. There exists a unique (up to isomorphism) $$\infty $$
∞
-ample complex on countable set of vertexes (the Rado complex), and the second part of the paper surveys the results about universality, homogeneity, indestructibility and other important properties of this complex. The Appendix written by J.A. Barmak discusses connectivity of conic and ample complexes.
Market impact and efficiency in cryptoassets markets
Authors: Barucci Emilio , Giuffra Moncayo Giancarlo , Marazzina Daniele 
Published: September 2023

AbstractWe analyze markets for cryptoassets (cryptocurrencies and stablecoins), investigating market impact and efficiency through the lens of the market order flow. We provide evidence that markets where cryptoassets are exchanged between themselves play a central role on price formation and are more efficient than markets where cryptocurrencies are exchanged with the US dollar. For the first set of markets we observe some evidence of the presence of insiders/contrarians, instead in the latter we observe the predominance of herding and trend-followers.
Besov regularity of inhomogeneous parabolic PDEs
Authors: Schneider Cornelia , Szemenyei Flóra Orsolya 
Published: September 2023

AbstractWe study the regularity of solutions of parabolic partial differential equations with inhomogeneous boundary conditions on polyhedral domains $$D\subset \mathbb {R}^3$$

D
⊂

R

3

in the specific scale $$\ B^{\alpha }_{\tau ,\tau }, \ \frac{1}{\tau }=\frac{\alpha }{3}+\frac{1}{p}\ $$

B

τ
,
τ

α

,

1
τ

=

α
3

+

1
p

of Besov spaces. The regularity of the solution in this scale determines the order of approximation that can be achieved by adaptive numerical schemes. We show that for all cases under consideration the Besov regularity is high enough to justify the use of adaptive algorithms. Our results are in good agreement with the forerunner (Dahlke and Schneider in Anal Appl 17:235–291, 2019), where parabolic equations with homogeneous boundary conditions were investigated.
Fluctuation-mediated orbital rotation of microparticles in non-coaxially counter-propagating optical tweezers
Authors: Setoura Kenji , kakimoto Takayasu , Miyasaka Hiroshi , Ito Syoji 
Published: September 2023

AbstractWe have demonstrated in the present report that dielectric microparticles exhibited orbital rotation in the light field of non-coaxially configured two counter-propagating laser beams both in numerical simulations and experiments. A series of computational simulations indicated that when irradiated with two non-coaxially counter-propagating parallel laser beams with the same intensity distributions in the absence of thermal (Brownian) motion, a microparticle did not exhibit orbital rotation due to the symmetry of the optical field. However, the computations predicted that a microparticle exhibited one directional orbital rotation in the presence of thermal motion because of the symmetry breaking of the optical force acting on the particle. This spontaneous orbital rotation was experimentally demonstrated for 1-µm dielectric particles in water at room temperature.
Graphical abstract
Rapid Expansion of Fixed Nitrogen Deficit in the Eastern Pacific Ocean Revealed by 50‐Year Time Series
Authors: Evans Natalya , Tichota Juliana , Ruef Wendi , Moffett James , Devol Allan 
Published: September 2023

AbstractClimate change is expected to increase the strength of ocean Oxygen Deficient Zones (ODZs), but we lack a detailed understanding of the temporal or spatial variability of these ODZs. A 50‐year time series in the Eastern Tropical North Pacific (ETNP) ODZ revealed that it has strengthened by 30% from 1994 to 2019. We subdivided the ODZ into a core and a deep layer based on potential density and revealed that different processes control the magnitude of fixed nitrogen loss between these regions. We postulate that the depth of the upper ETNP ODZ water mass, the 13°C Water, influences the organic carbon supply to the core ODZ and therefore its strength. We correlated the maximum fixed nitrogen loss in the core ODZ with a nearby sedimentary nitrogen isotope record and found that this recent increase in the magnitude of fixed nitrogen loss occurred only a few times over the last 1,200 years. Using this correlation, we derived the first confidence interval for the natural variability of the maximum fixed nitrogen loss within the ETNP ODZ, which has a range of 3.3 μmol kg−1 (p = 0.01). While the current increase is only comparable to two previous events, it is within the confidence interval for natural variability (p = 0.03). The deep ODZ also strengthened from 2016 to 2019 by approximately 30%, but this increase occurred more rapidly than the core ODZ, and this dramatic increase was not observed over the rest of the 40 years. Climate‐driven intensification could lead to unprecedented changes in the ETNP ODZ within the next decade.
Sources and Fate of Sedimentary Organic Matter in the Western Mediterranean Sea
Authors: Ausín Blanca , Bossert Gina , Krake Nicola , Paradis Sarah , Haghipour Negar , Durrieu de Madron Xavier , Alonso Belén , Eglinton Timothy 
Published: September 2023

AbstractMarine sediments comprise the primary long‐term sink of organic matter (OM) in marine systems. Disentangling the diverse origins of OM and the influence of the main processes that determine organic carbon (OC) fate at a global scale has proven difficult due to limited spatial data coverage. Thus, comprehensive studies of the spatial distribution of the content and geochemical characteristics of sedimentary OM at basin scales provide fundamental knowledge on the role of marine sediments in the global carbon cycle. Here, we shed light on the origin of OM and the underlying mechanisms that determine its fate in a semi‐enclosed basin by examining the spatial patterns in the isotopic and elemental composition of OM in 149 core‐top samples from the Western Mediterranean Sea and the adjacent Atlantic Ocean sector. Our results reveal an apparent SW‐NE gradient that reverses in the Gulf of Lions in most geochemical and sedimentological features. Changes in the OC content and ẟ13C and Δ14C signatures are ascribed to spatial variations in marine primary productivity and the influence of varying discharge of rivers and well‐developed canyons that favor the cross‐shelf transport of terrestrial (and petrogenic) OC. Our results also suggest the potential influence of two other mechanisms on the geochemical signatures of OM: (a) lateral transport of allochthonous OC and selective degradation of labile OM, which potentially occurs across the studied area having a greater impact toward the north‐eastern region, and (b) OM protection via association with mineral surfaces, potentially having a greater influence toward the south‐western basins.
Model‐Dependent Atlantic Multidecadal Variability Modulations on North Pacific Sea Surface Temperature Variability and Decadal Prediction
Authors: Lv Zhen , Yang Jun‐Chao , Zhang Yu , Lin Xiaopei 
Published: September 2023

AbstractPrevious studies suggested that Atlantic Multidecadal Variability (AMV) modulations on pan‐Pacific sea surface temperature (SST) variability and prediction are model‐dependent. These results were mainly based on SST forcing experiments in which AMV‐related Atlantic SST anomalies were prescribed. However, the AMV itself is also model‐dependent, but its influences on the Pacific remain unclear. Here, we use multi‐model fully coupled experiments from the Coupled Model Intercomparison Project Phase 6 (CMIP6), along with observations, to study the model‐dependent AMV trans‐basin effects. We found that AMV strength is a key factor: Stronger (Weaker) model AMV than observations overestimates (underestimates) SST response and decadal prediction skills, mainly in the North Pacific. The reason is that stronger positive phased AMV, for example, leads to higher sea level pressure anomalies over the North Pacific, which lifts sea surface height and deepens thermocline to warm SST. Our study highlights the necessity to improve simulations of AMV strength.