bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of [225Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration
Authors: Hull Ashleigh , Hsieh William , Borysenko Artem , Tieu William , Bartholomeusz Dylan , Bezak Eva 
Published: September 2023

AbstractBackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy which may benefit from radioimmunotherapy. Previously, [177Lu]Lu-DOTA-C595 has been developed as a beta-emitting radioimmunoconjugate to target cancer-specific mucin 1 epitopes (MUC1-CE) overexpressed on PDAC. However, the therapeutic effect may be enhanced by using an alpha-emitting radionuclide such as Actinium-225 (Ac-225). The short range and high linear energy transfer of alpha particles provides dense cellular damage and can overcome typical barriers related to PDAC treatment such as hypoxia. Despite the added cytotoxicity of alpha-emitters, their clinical implementation can be complicated by their complex decay chains, recoil energy and short-range impeding radiation detection. In this study, we developed and evaluated [225Ac]Ac-DOTA-C595 as an alpha-emitting radioimmunotherapy against PDAC using a series of in vitro experiments and conducted a preliminary dosimetric assessment and cross-calibration of detectors for the clinical implementation of Ac-225.ResultsCell binding and internalisation of [225Ac]Ac-DOTA-C595 was rapid and greatest in cells with strong MUC1-CE expression. Over 99% of PDAC cells had positive yH2AX expression within 1 h of [225Ac]Ac-DOTA-C595 exposure, suggesting a high level of DNA damage. Clonogenic assays further illustrated the cytotoxicity of [225Ac]Ac-DOTA-C595 in a concentration-dependent manner. At low concentrations of [225Ac]Ac-DOTA-C595, cells with strong MUC1-CE expression had lower cell survival than cells with weak MUC1-CE expression, yet survival was similar between cell lines at high concentrations irrespective of MUC1-CE expression. A dosimetric assessment was performed to estimate the dose-rate of 1 kBq of [225Ac]Ac-DOTA-C595 with consideration to alpha particles. Total absorption of 1 kBq of Ac-225 was estimated to provide a dose rate of 17.5 mGy/h, confirmed via both detector measurements and calculations.Conclusion[225Ac]Ac-DOTA-C595 was shown to target and induce a therapeutic effect in MUC1-CE expressing PDAC cells.
Epidemiological analysis of patients with psoriatic arthritis in follow-up at the brazilian Unified Health System
Authors: Rossetto Chayanne Natielle , Palominos Penélope Esther , Machado Natalia Pereira , dos Santos Paiva Eduardo , Azevedo Valderílio Feijó 
Published: September 2023

Abstract
Introduction/Objectives
Psoriatic arthritis (PsA) is a chronic multisystem osteoarticular disease that requires specialized care. Most Brazilians depend on the public healthcare provided by the Unified Health System (Sistema Único de Saúde, SUS). This study aimed to describe the epidemiological characteristics of patients with PsA in follow-up in SUS, focusing on the incidence and prevalence of the disease, comorbidities, and hospitalizations.

Methods
We collected data from the Outpatient Data System of SUS (Sistema de Informações Ambulatoriais do SUS, SIA/SUS) regarding outpatient visits and hospitalizations in the Brazilian public healthcare system from January 2008 to March 2021 using the Techtrials Disease Explorer® platform and the medical code related to PsA were selected.

Results
We evaluated 40,009 patients and found a prevalence of 24.4 cases of visits due to PsA per 100,000 patients in follow-up in SUS. Female patients were predominant (54.38%). The incidence of visits due to PsA has been increasing in recent years and we observed an incidence of 8,982 new visits in 2020. The main comorbidities of these patients were osteoarthritis, lower back pain, shoulder injuries, oncological diseases, crystal arthropathies, and osteoporosis. Hospitalizations were mainly due to treating clinical or cardiovascular conditions and performing orthopedic procedures.

Conclusion
The number of visits due to PsA in SUS has increased in recent years, mainly on account of new diagnoses of the disease, although the prevalence found in this study’s population was lower than that observed in the general population.
Autism in adult psychiatric out-patients: self-reported suicidal ideation, suicide attempts and non-suicidal self-injury
Authors: Nyrenius Johan , Waern Margda , Eberhard Jonas , Ghaziuddin Mohammad , Gillberg Christopher , Billstedt Eva 
Published: September 2023

Background
The prevalence of self-reported suicidal ideation, suicide attempts and non-suicidal self-injury (NSSI) remains unclear among adults with autism unrecognised in childhood who attend psychiatric services.

Aims
We aimed to estimate the prevalence of suicidal ideation, suicide attempts and NSSI; identify factors associated with suicide attempts and NSSI; and describe NSSI in this group.

Method
Sixty-three new patients at an adult psychiatric out-patient clinic (57% women, mean age 32 years) who met full (n = 52) or subthreshold (two A criteria and minimum of two B criteria; n = 11) DSM-5 criteria for autism spectrum disorder were included in the study. Clinical assessments included overall diagnostic review, Paykel's questions on passive and active suicidality, evaluation of NSSI with the Functional Assessment of Self-Mutilation, and results of cognitive tests. One follow-up of medical records was made.

Results
In this sample of psychiatric out-patients identified as first having autism in adulthood, almost a third (31%) of patients reported suicidal ideation during the past month, 86% had lifetime suicidal ideation and 25% reported at least one suicide attempt. Factors associated with suicide attempts included hazardous or harmful alcohol use and/or drug-related problems, and severity of depression. A total of 44% reported NSSI. Factors associated with NSSI were female sex, history of suicidal plans and antisocial personality disorder. Substance or alcohol use were often overlooked, especially in women.

Conclusions
Suicidal ideation, suicide attempts and NSSI were very common in adults with autism who were recently referred to an out-patient psychiatric service. Suicidal ideation and NSSI were more common than suicide attempts. Clinicians should always consider suicidal ideation and NSSI in adult psychiatric patients with autism.
Electronic Patient-Reported Outcome Data Collection Systems in Oncology Clinical Trials: A Survey of Clinical Research Professionals (an Alliance Study)
Authors: Cho Youmin , Lavoie Smith Ellen M. , Zahrieh David , Chow Selina L. , Williams David A. , Saint Arnault Denise , Jiang Yun 
Published: September 2023

PURPOSE To describe clinical research professionals (CRPs)’ experiences with electronic patient-reported outcome (ePRO) data collection systems in oncology clinical trials and identify correlates of CRPs' attitude toward technology. METHODS An online survey was conducted among 210 CRPs from 125 National Cancer Institute–funded research sites. Measures included CRPs' demographic characteristics, working years, employment locations, and previous experiences with various types of ePROs. Their attitude toward technology was measured by the Technology Attitude Scale-Adapted. The Wilcoxon signed-rank test was used to compare two subdomains of attitude (perceived usefulness [PU] and perceived ease of use [PEU]). Multiple linear regression was used to explore correlates of (1) overall attitude, (2) PU, and (3) PEU. The significance level was 5%. RESULTS Participants' median age was 41 years (range, 21-67). Most were female (90%) and White (82%). More than half of the participants had previous experiences with web-based ePROs using patients' own devices (72%) or site-/sponsor-provided on-site devices (eg, kiosks or tablets; 64%). CRPs who were 60 years or older (β = −0.32, P < .05) or worked for 10-20 years (β = −0.11, P < .05) had relatively negative attitudes, controlling for other factors. Previous experiences with more ePRO types were associated with more positive attitudes (β = 0.08, P = .02). Similar correlates were found with PU but not with PEU. CONCLUSION This study revealed that CRPs had various experiences with ePRO systems and attitudes toward technology. Age, working years, and previous experiences with ePROs were correlates of overall attitude toward technology and PU. These findings suggest necessary targeted training to facilitate ePRO use in oncology clinical trials by improving CRPs' awareness and attitude toward technology.
Effects of Ketogenic Diet on Reproductive Hormones in Women With Polycystic Ovary Syndrome
Authors: Khalid Karniza , Apparow Saraswathy , Mushaddik Irma Liyana , Anuar Amalina , Rizvi Syed A A , Habib Anasufiza 
Published: September 2023

Abstract

Context
Ketogenic diet has recently made a comeback as a part of lifestyle and dietary modifications in patients with polycystic ovary syndrome (PCOS). Despite studies suggesting its beneficial effects in reversing hormonal imbalance in women with PCOS, evidence has been patchy and derived from small populations under varying conditions.

Objective
To pool evidence from clinical trials to study the effects of ketogenic diet on reproductive hormones (LH/FSH ratio, free testosterone, serum progesterone) and observe evidence of weight change.

Methods
PubMed, ScienceDirect, Scopus, and Web of Science core collection were searched for clinical trials evaluating the effects of ketogenic diet in established PCOS women consistent with the Rotterdam classification. Single- or double-arm studies that included an outcome of interest were included. Two investigators worked independently to screen potential articles and a designated investigator extracted data on study characteristics and evaluated the outcomes. Data were pooled using a random-effects model. The quality of selected studies was assessed using the Cochrane Risk of Bias Tool.

Results
Following ≥45 days of intervention with ketogenic diet among women with PCOS, significant improvement was observed in reproductive hormone levels, with reduced LH/FSH ratio (d −0.851; 95% CI −1.015, −0.686; P &lt; .001), reduced serum free testosterone (d −0.223; 95% CI −0.328, −0.119; P&lt; .001), and an increased in serum sex hormone binding globulin (SHBG) (d 9.086; 95% CI 3.379, 14.792; P = .002). Significant weight loss was unanimously observed in all included studies (d −11.56; 95% CI −14.97, −8.15; P &lt; .001).

Conclusion
Short-term ketogenic diet potentially improved hormonal imbalances commonly associated with PCOS.
DPH1 and DPH2 variants that confer susceptibility to diphthamide deficiency syndrome in human cells and yeast models
Authors: Ütkür Koray , Mayer Klaus , Khan Maliha , Manivannan Thirishika , Schaffrath Raffael , Brinkmann Ulrich 
Published: September 2023

ABSTRACT
The autosomal-recessive diphthamide deficiency syndrome presents as intellectual disability with developmental abnormalities, seizures, craniofacial and additional morphological phenotypes. It is caused by reduced activity of proteins that synthesize diphthamide on human translation elongation factor 2. Diphthamide synthesis requires seven proteins (DPH1-DPH7), with clinical deficiency described for DPH1, DPH2 and DPH5. A limited set of variant alleles from syndromic patients has been functionally analyzed, but databases (gnomAD) list additional so far uncharacterized variants in human DPH1 and DPH2. Because DPH enzymes are conserved among eukaryotes, their functionality can be assessed in yeast and mammalian cells. Our experimental assessment of known and uncharacterized DPH1 and DPH2 missense alleles showed that six variants are tolerated despite inter-species conservation. Ten additional human DPH1 (G113R, A114T, H132P, H132R, S136R, C137F, L138P, Y152C, S221P, H240R) and two DPH2 (H105P, C341Y) variants showed reduced functionality and hence are deficiency-susceptibility alleles. Some variants locate close to the active enzyme center and may affect catalysis, while others may impact on enzyme activation. In sum, our study has identified functionally compromised alleles of DPH1 and DPH2 genes that likely cause diphthamide deficiency syndrome.
Sexual functioning is not, but psychological burden is predictive for seeking help in pelvic physical therapy practice: A cross-sectional study
Authors: Brand Alma , Waterink Wim , van Lankveld Jacques 
Published: September 2023

Background. Pelvic floor complaints are common among women and often accompanied by sexual dysfunction and psychological burden. They are also associated with pregnancy and childbirth. However, not all women with these complaints seek help in pelvic physical therapy practice. This study explored if pregnancy, parity, pelvic floor complaints, sexual functioning, and psychological burden are predictive of seeking help in pelvic physical therapy practice. Methods. In a cross-sectional exploratory design, women completed an online survey about pelvic floor complaints, sexual function, and psychological burden. Binary logistic analysis was used to analyze the predictive value of the above-mentioned factors. Results. Data from 542 participants were analyzed. Pregnancy and parity, PFC severity, psychological burden, and the interaction between pelvic floor complaints and psychological burden were significant predictors of seeking help. Against expectations, sexual functioning was not predictive of seeking help. Conclusions. Women’s psychological burden is an important factor in determining if or when women seek help in PPT practice. More research is needed to unravel the role of sexual functioning in the context of pelvic floor complaints and women’s psychological burden. More insight into this area of expertise could possibly improve and enhance pelvic health care for women with pelvic floor complaints.
Deriving and validating an asthma diagnosis prediction model for children and young people in primary care
Authors: Daines Luke , Bonnett Laura J , Tibble Holly , Boyd Andy , Thomas Richard , Price David , Turner Steve W , Lewis Steff C , Sheikh Aziz , Pinnock Hilary 
Published: September 2023

Introduction: Accurately diagnosing asthma can be challenging. We aimed to derive and validate a prediction model to support primary care clinicians assess the probability of an asthma diagnosis in children and young people. Methods: The derivation dataset was created from the Avon Longitudinal Study of Parents and Children (ALSPAC) linked to electronic health records. Participants with at least three inhaled corticosteroid prescriptions in 12-months and a coded asthma diagnosis were designated as having asthma. Demographics, symptoms, past medical/family history, exposures, investigations, and prescriptions were considered as candidate predictors. Potential candidate predictors were included if data were available in ≥60% of participants. Multiple imputation was used to handle remaining missing data. The prediction model was derived using logistic regression. Internal validation was completed using bootstrap re-sampling. External validation was conducted using health records from the Optimum Patient Care Research Database (OPCRD). Results: Predictors included in the final model were wheeze, cough, breathlessness, hay-fever, eczema, food allergy, social class, maternal asthma, childhood exposure to cigarette smoke, prescription of a short acting beta agonist and the past recording of lung function/reversibility testing. In the derivation dataset, which comprised 11,972 participants aged <25 years (49% female, 8% asthma), model performance as indicated by the C-statistic and calibration slope was 0.86, 95% confidence interval (CI) 0.85–0.87 and 1.00, 95% CI 0.95–1.05 respectively. In the external validation dataset, which included 2,670 participants aged <25 years (50% female, 10% asthma), the C-statistic was 0.85, 95% CI 0.83–0.88, and calibration slope 1.22, 95% CI 1.09–1.35. Conclusions: We derived and validated a prediction model for clinicians to calculate the probability of asthma diagnosis for a child or young person up to 25 years of age presenting to primary care. Following further evaluation of clinical effectiveness, the prediction model could be implemented as a decision support software.
Design study of a micro illumination platform based on GaN microLED arrays
Authors: Di Vito Alessia , Amiri Peyman , Bornemann Steffen , Schöttler Georg , Vergin Maximilian , Meierhofer Florian , Gülink Jan , Waag Andreas , Canals Joan , Diéguez Angel , Prades J. Daniel , Auf der Maur Matthias 
Published: September 2023

The design study of a micro illumination tool based on GaN microLED arrays is presented. The high spatio-temporal resolution and the capability of generating fully customized optical patterns that characterize the proposed platform would enable the manipulation of biological systems, e.g., for optogenetics applications. Based on ray tracing simulations, the design aspects that mainly affect the device performance have been identified, and the related structural parameters have been optimized to improve the extraction efficiency and the spatial resolution of the resulting light patterns. Assuming that the device is a bottom emitter, and the light is extracted from the n-side, the presence of mesa-structures on the p-side of the GaN layer can affect both the efficiency and the resolution, being optimized for different values of the mesa-side inclination angle. The full width at half maximum (FWHM) of the extracted spots is mainly determined by the substrate thickness, and the relation between the FWHM and the array pitch represents a criterion to define the resolution. Namely, when FWHM<pitch, the spots are assumed to be resolved, while, when FWHM=pitch, a homogeneous distribution of light intensity is observed. The best performance is obtained when an in-GaN micro-lens array is included in the simulated structure, assuming that the substrate has been removed. The spatial resolution of the generated light pattern results as fully preserved, while the extraction efficiency in the best case is up to three times larger than that of a planar GaN/air interface.
Alignment and characterization of remote-refocusing systems
Authors: Hong Wenzhi , Sparks Hugh , Dunsby Chris 
Published: September 2023

The technique of remote refocusing is used in optical microscopy to
provide rapid axial scanning without mechanically perturbing the
sample and in techniques such as oblique plane microscopy that build
on remote refocusing to image a tilted plane within the sample. The
magnification between the pupils of the primary (O1) and secondary
(O2) microscope objectives of the remote-refocusing system has been
shown previously by Mohanan and Corbett [J. Microsc.
288, 95 (2022)JMICAR0022-272010.1111/jmi.12991] to be
crucial in obtaining the broadest possible remote-refocusing range. In
this work, we performed an initial alignment of a remote-refocusing
system and then studied the effect of axial misalignments of O1 and
O2, axial misalignment of the primary tube lens (TL1) relative to the
secondary tube lens (TL2), lateral misalignments of TL2, and changes
in the focal length of TL2. For each instance of the setup, we
measured the mean point spread function FWHMxy of 100 nm fluorescent beads and the
normalized bead integrated fluorescence signal, and we calculated the
axial and lateral distortion of the system; all of these quantities
were mapped over the remote-refocusing range and as a function of
lateral image position. This allowed us to estimate the volume over
which diffraction-limited performance is achieved and how this changes
with the alignment of the system.
“There's Power in that Y”: How Gaymers Manage Imbricated Stigma through an Equipollent Identity
Authors: Bikowski Kyle 
Published: September 2023

Abstract
Portmanteau identities, such as “Gaymer” (gay-gamer), can shed light on the important social work that identity labels do for those who choose to adopt them. In this article, I analyze how “Gaymer” is not just a convenient portmanteau, but an identity used to manage stigma and advance inclusivity for people inhabiting identities often viewed as mutually exclusive. I demonstrate this with data gathered through actual world ethnographic research with Gaymers at a monthly meetup in Houston, Texas, and virtual world ethnographic research with two Facebook Groups. I found that Gaymers are often excluded from both the gaming community and the mainstream gay community, however, rather than try to minimize contradictions in their identity, they seek to create contradictions by gaming in gay bars, performing in drag shows as video game characters, and advocating for more inclusivity at gaming conventions, among other tactics. My results show a critical need to move beyond an examination that multiple stigmas exist, toward a study of how they interact. I build upon Russian linguist Nikolai Trubetzkoy's concepts of privative and equipollent markedness to show how the interaction between “gay” and “gamer” has resulted in the creation and performance of a “Gaymer” identity, what I call an equipollent identity. Recognizing the existence of equipollent identities, like Gaymer, invites consideration of the potentially positive and productive ways that stigmatized individuals manage stigma and build community.
PERSPEKTIF FILSAFAT AGAMA TENTANG KERUKUNAN BERAGAMA
Authors: Theguh Saumantri  
Published: September 2023

Indonesia, as a country rich in cultural, ethnic, and religious diversity, has faced complex challenges in achieving social harmony and inter-religious harmony. Over time, the complexity of religious diversity has given rise to a number of problems, including inter-religious conflicts, insults, and a lack of understanding of the principles of religious harmony. This study aims to enrich the understanding of the concept of religious harmony from the perspective of religious philosophy as well as identify the contribution of religious philosophy to enriching the understanding of religious harmony in the context of religious diversity in Indonesia. This research uses a descriptive research method with a phenomenological approach. Based on the analysis conducted, it can be interpreted that religious harmony is a fundamental concept in the lives of religion and society. This relates to the formation of an attitude of tolerance, mutual respect, and understanding differences. In the philosophy of religion, religious harmony can be built through Synergizing Religious pluralism, involving Inter-Religious Dialogue, and implementing Religious Ethics and Morality holistically.
Keywords: Religious Harmony, Religious Philosophy, Tolerance.

Abstrak
Indonesia, sebagai negara yang kaya akan keberagaman budaya, etnis, dan agama, telah menghadapi tantangan kompleks dalam mencapai harmoni sosial dan kerukunan antarumat beragama. seiring berjalannya waktu, kompleksitas keberagaman agama telah menimbulkan sejumlah permasalahan, termasuk konflik antaragama, diskriminasi, dan kurangnya pemahaman tentang prinsip-prinsip kerukunan beragama. Penelitian ini bertujuan untuk memperkaya pemahaman tentang konsep kerukunan beragama dalam perspektif filsafat agama, serta mengidentifikasi kontribusi filsafat agama dalam memperkaya pemahaman tentang kerukunan beragama dalam konteks keberagaman agama di Indonesia. Penelitian ini menggunakan metode penelitian kualitatif deskriptif dengan pendekatan fenomenologi. Berdasarkan analisis yang dilakukan, dapat disimpulkan bahwa kerukunan beragama merupakan konsep fundamental dalam kehidupan beragama dan masyarakat. Hal ini berkaitan dengan terbentuknya sikap toleransi, saling menghormati, dan memahami perbedaan. Dalam filsafat agama, kerukunan beragama dapat dibangun melalui Mensinergikan Pluralitas Agama, melibatkan Dialog Inter-Religius, serta menerapkan Etika dan Moralitas Agama secara holistik.
Kata kunci: Kerukunan Beragama, Filsafat Agama, Toleransi.