bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Projek Penguatan Profil Pelajar Pancasila (P5) dalam Tema Kewirausahaan Kelas VIII di SMPN 6 Lembang Jaya, Kabupaten Solok
Authors: Amanda Friska , Rahayu Sri , Harisnawati  
Published: January 2025

Penelitian ini dilatarbelakangi oleh beberapa kendala dalam pelaksanaan Projek Penguatan Profil Pelajar Pancasila di SMP N 6 Lembang Jaya. yaitu seperti kendala, guru dan sekolah kesulitan menentukan tema projek yang bisa membuat siswa bersemangat dalam melaksanakan projek, kurangnya pemahaman guru dalam menyusun modul, kendala dalam penyedian alat dan bahan, sulit bekerjasama lintas sektor, pesatnya arus globalisasi sehingga membawa nilai-nilai yang tidak sesuai dengan karakteristik bangsa. Tujuan penelitian ini untuk mendeskripsikan kegiatan Implementasi Projek Penguatan Profil Pelajar Pancasila Tema Kewirausahaan kelas VIII di SMP N 6 Lembang Jaya. Teori yang digunakan dalam penelitian ini yaitu teori Konstruktivisme. Pendekatan dalam penelitian ini adalah kualitatif dengan tipe deskriptif. Teknik menentukan informan secara Purposive Sampling. Adapun informan dalam penelitian ini antara lain kepala sekolah, waka kurikulum, koordinator projek kewirausahaan, tim fasilitator kewirausahaan, dan siswa. Jenis data, data primer dan sekunder. Teknik pengumpulan data yang dilakukan dengan cara observasi, wawancara, dan studi dokumen. Unit analisis dalam penelitian ini adalah kelompok. Teknik analisis data dalam penelitian ini adalah pengumpulan data, reduksi data, penyajian data, dan verifikasi data. Maka hasil penelitian yang telah dilakukan di SMP N 6 Lembang Jaya kabupaten Solok, menunjukkan bahwa pelaksanaan Projek Penguatan Profil Pelajar Pancasila dalam tema kewirausahaan diawali dengan tahap perencanaan terlebih dahulu, yaitu dengan membentuk tim fasilitator, mengidentifikasi tingkat kesiapan satuan pendidikan, merancang tema, topik dan alokasi waktu P5, menyusun modul, dan merancang pelaporan hasil prosek, serta tahap terakhir dalam pelaksanaan kegiatan projek ini adalah dengan melakukan tahapan evaluasi terhadap kegiatan P5 tersebut.
Proses Tradisi Ngorek dalam Upacara Nyongkolan pada Masyarakat Sasak Desa Tanak Awu Kecamatan Pujut Kabupaten Lombok Tengah
Authors: Akbar Ahmad Naufal , Masyhuri  , Nursapti  , Suud  
Published: January 2025

Penelitian ini bertujuan untuk: mengetahui proses tradisi ngorek dalam upacara nyongkolan pada masyarakat sasak desa Tanak Awu Kecamatan Pujut Lombok Tengah. Penelitian ini menggunakan pendekatan kulitatif dengan metode etnografi. Data yang di gunakan dengan sumber data primer dan data sekunder dengan sumber data subjek dan informan penelitian. Pengumpulan data dalam penelitian ini menggunakan teknik wawancara, observasi dan dokumentasi. Sedangkan analisis data menggunakan tehnik analisis yang dikembangkan oleh Miles dan Hubermen dengan tahapan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian mengungkapkan bahwa (1) pelaksanaan tradisi ngorek dilakukan melalui tiga tahap yaitu tahap persiapan, mempersiapkan alat dan bahan tradisi ngorek Upacara Nyongkolan Pada Masyarakat Sasak Desa Tanak Awu seperti baju adat keris dan minyak sengkebal, (2) pelaksanaan tradisi ngorek dilakukan pada acara Nyongkolan Pada Masyarakat Sasak Desa Tanak Awu dengan menusuk diri ataupun pengorek lainnya dengan senjata tajam kebadan dan anggota badan lainnya , dan (3) penutup tradisi ngorek Upacara Nyongkolan Pada Masyarakat Sasak Desa Tanak Awu yang diakhiri dengan bubarnya peserta nyongkolan dan pengorek.
Instrumentos de evaluación para el Aprendizaje Reflexivo en alumnos de Telesecundaria en México
Authors: Guerrero Rodríguez Lilia Esther , Dajer Torres Regina , Villalobos López Marilú , Ramírez Nieto Elodia , Miranda Hernández Samantha Emiret 
Published: January 2025

Los instrumentos de evaluación para el aprendizaje reflexivo permiten identificar y evaluar el logro de aprendizaje de los educandos, al hacer uso de la constante reflexión y participación activa sobre lo que aprenden. En el caso de la telesecundaria, este proceso es fundamental para lograr la integración y aplicación de los contenidos vistos en sus clases televisadas. La presente investigación tuvo como objetivo analizar la perspectiva de alumnos de telesecundaria sobre el uso de instrumentos de evaluación del aprendizaje reflexivo empleado por docentes y su integración en el proceso educativo. Para este estudio se utilizó el paradigma cualitativo a través de la aplicación de una entrevista a un grupo de 24 estudiantes de una institución de educación telesecundaria ubicada en Veracruz, México. Como resultado se obtuvo tres categorías de análisis: a) importancia de los instrumentos de evaluación, b) beneficios de los diferentes instrumentos que utiliza el docente y c) pensamiento reflexivo como parte de la formación educativa y personal. Los resultados más sobresalientes muestran que los alumnos al pensar reflexivamente se sienten más seguros al participar en clase, les ayuda en el reforzamiento de los temas vistos y logran tomar mejores decisiones a partir de la información dada.
Optimalisasi Slurry dan Baglog Terhadap Peningkatan Kualitas Bahan Baku Kompos
Authors: Titin Eka Setianingsih  
Published: January 2025

Pemanfaatan slurry dapat berpotensi sebagai sumber bahan baku kompos. Hal ini berkaitan dengan bahan organik dan nitrogen pada slurry yang tinggi. Slurry memiliki C/N rasio rendah sebesar 7,4 yang dapat mengakibatkan kehilangan nitrogen melalui NH3 dan NO2. Perlunya manajemen untuk pengelolaan slurry seperti penambahan bahan baku baglog. Baglog merupakan limbah media dalam budidaya jamur. Baglog memiliki C/N rasio sebesar 35,21. C/N rasio tinggi menyebabkan bau pada bahan baku kompos karena mikroba utama tidak tersedia. Sehingga diperlukan kombinasi bahan baku kompos dari bahan dengan nilai C/N rasio terendah harus dicampurkan dengan bahan yang memiliki C/N rasio tinggi. Tujuan dari penelitian ini adalah untuk mengetahui kombinasi bahan baku kompos berupa slurry dan baglog terhadap kualitas kompos yang sesuai dengan baku mutu. Percobaan penelitian kompos terdiri dari enam perlakuan meliputi K1 (slurry 25 liter + baglog 25 kg+ dekomposer 0 ml), K2 (slurry 25 liter + baglog 25 kg + dekomposer 3 ml/1000 mL) , K3 (slurry 30 liter+ baglog 20 kg + dekomposer 3 ml/1000 mL), K4 (slurry 40 liter + baglog 30 kg + dekomposer 3 ml/1000 mL), K5 (slurry 50 liter + 25 kg+ dekomposer 3 ml/1000 mL) + K6 slurry 25 liter + baglog 50 kg+ dekomposer 3 ml/1000 mL). Perlakuan K1 hingga K4 menunjukkan sesuai dengan standar mutu kompos Permentan No 01 (2019). Aplikasi K2 (slurry 25 liter + baglog 25 kg + dekomposer 3 ml/1000 mL) menghasilkan nilai nitrogen yang lebih tinggi dibandingkan perlakuan lainnya.
História e patrimônio arquitetônico rural
Authors: Norder Luiz Antonio Cabello , Poyares Gustavo de Andrade 
Published: January 2025

Este texto tem o objetivo de analisar fontes de informação para uma identificação e caracterização da Fazenda Santa Escolástica no século XIX, cujas antigas edificações pertencem atualmente à Universidade Federal de São Carlos (UFSCar). Foram consultadas as seguintes fontes primárias de informação: escrituras do imóvel, dados genealógicos, registro paroquial de terras, registros de batismo e óbito de pessoas escravizadas, notícias de jornais e um relato gravado em 2005. Com as informações obtidas, foi possível identificar a família proprietária e aspectos de sua atuação política, elaborar um perfil demográfico e das relações de compadrio da população escravizada na fazenda, e apresentar algumas interpretações sobre as edificações remanescentes.
Red Laser-Activated Silver Nanoparticles from Green Synthesis Extract of Butterfly Pea for Antimicrobial Photodynamic Therapy Against Staphylococcus aureus
Authors: Astuti Suryani Dyah , Farhah Ghinaa Rihadatul Aisy , Salwa Umaimah Mitsalia Ummi , Aisya Rohadatul , Zaidan Andi Hamim , Yaqubi Ahmad Khalil 
Published: January 2025

This study investigated the potential of photodynamic therapy (PDT) using green-synthesized silver nanoparticles (AgNPs) derived from butterfly pea extract (Clitoria ternatea L.) to combat Staphylococcus aureus (S. aureus). The use of a red diode laser as a method for enhancing the antimicrobial activity of AgNPs presents a novel approach to treating bacterial infections. The red diode laser is crucial, as it activates the AgNPs, enhancing their antimicrobial properties. This combination of light, natural extract, and nanoparticles underscores the innovative approach of using PDT in treating bacterial infections. By integrating these elements, the study aims to provide insights into effective, biocompatible treatments for antibiotic-resistant bacteria. The primary objective of this study is to synthesize and characterize AgNPs using butterfly pea extract and evaluate their effectiveness against S. aureus when combined with red laser irradiation. Silver nanoparticles were synthesized using an environmentally friendly method that processes butterfly pea extract as the reducing agent for the synthesis of the nanoparticles. Using UV-Vis spectrophotometry to track the creation of silver nanoparticles (AgNPs), it was determined that the butterfly pea extract was an effective source of nanoparticles. The particle size distribution and peak absorbance wavelength were determined by characterization utilizing a Particle Size Analyzer (PSA). Tryptic soy agar (TSA) plates were used to investigate the antibacterial activity of AgNPs against Staphylococcus aureus (S. aureus). The effectiveness of photoinactivation against S. aureus was evaluated by exposing AgNPs at a concentration of 1 mM to a red diode laser for 90 seconds. The results showed that the produced AgNPs had potential antibacterial capabilities when combined with red light therapy. The results demonstrated that the synthesized silver nanoparticles can effectively kill or inhibit the growth of Staphylococcus aureus (S. aureus) when exposed to a red diode laser for 90 seconds. The findings suggest that photodynamic therapy using green-synthesized AgNPs and red laser irradiation could be a promising approach to controlling bacterial infections like S. aureus. Further research is recommended to explore the underlying mechanisms of photoinactivation and to optimize treatment parameters for in vivo applications on experimental animals.
Assessing the Experiences of Sexual and Gender Minority Applicants to Orthopaedic Surgery Residency
Authors: Weaver Douglas J. , Dagher Tanios , Duong Ngoc , Winfrey Sara , Koo Alexander , Balach Tessa 
Published: January 2025

Introduction:
The rate of sexual and gender minority (SGM) orthopaedic surgeons is far less than in other specialties, and the field has, in part, had significant difficulty attracting SGM applicants. To provide a more welcoming environment, identifying where applicants experience discrimination along medical training must be of paramount concern. Our objective was to understand the challenges faced by SGM medical students applying into orthopaedic surgery.

Methods:
An anonymous survey was sent to applicants of a single orthopaedic residency program in 2023, soliciting demographics, exposure to lesbian, gay, bisexual, transgender, and/or queer (LGBTQ) mentors, and experiences with discrimination. Data were stratified by sexual orientation, and univariate analysis was conducted using chi-squared tests. Afterward, logistic regressions adjusted for gender, age, and race were performed.

Results:
The overall response rate was 15.4% (n = 136/881). Fifteen percent (n = 20/135) identified as LGBTQ. Sixty-one percent of LGBTQ-identifying applicants experienced slurs and/or hurtful comments during orthopaedic rotations and research experiences, compared with 28% of their heterosexual peers (p < 0.001). In adjusted logistic regression models, LGBTQ respondents were 3.8 times more likely to report experiencing a hostile environment during training (p = 0.04) and 4.9 times more likely to have reported facing discrimination (p = 0.04) compared with heterosexual participants. Approximately 58% of respondents reported never having interacted with an LGBTQ-identifying orthopaedic attending, with only 5% reporting frequent interaction.

Conclusion:
LGBTQ-identifying orthopaedic surgery applicants experience barriers related to their sexual identity, including derogatory comments, hostile clinical environments, and lack of LGBTQ mentorship. These findings highlight challenges inherent to the residency application process that may disproportionately affect persons from sexual minority groups. The recognition of such challenges can help to optimize the establishment of informed policies regarding mistreatment and practices regarding diversity and inclusion.
RNA-multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation
Authors: huan Yao , Zhang Danru , Jin Haixia , Guo Yanjie , Liu Yan , Wang Shengnan , Yuan Shenli , LU Gang , Sun Ying-Pu 
Published: January 2025

Abstract

Most RNA molecules are present with m7G-cap and Poly(A)-tail at the 5’ or 3’ termini. However, existing next-generation sequencing (NGS) based single-cell RNA-sequencing methods are limited in capturing complete RNA molecules, often missing critical information at the 5’ or 3’ termini. Here, we developed a method named Cap to Tail sequencing application (C2T-APP) and simultaneously characterized the m7G cap, poly(A) tail structure, and gene expression level for the intact RNA molecules in single cells. C2T-APP distinguished the N6, 2′-O-dimethyladenosine modification (m6Am) from N6-methyladenosine (m6A) modification with our published single-cell m6A sequencing (scm6A-seq) data. During oocyte maturation, we found a positive correlation between m7G and m6Am to translation efficiency, and finely dissected the step-wised maternal RNA de-capping and de-tailing of different types of genes. Strikingly, we found that maternal RNA metabolism is strictly regulated by the translation process in the oocytes. Furthermore, we profiled the single-cell RNA-multi-omics of human oocytes of different qualities and the defect of epi-transcriptome features, including m6A, m6Am, m7G, and Poly(A) structure of maternal RNA in the oocytes with poor quality were detected. Our results provided valuable resources and novel insights into human oocyte maturation, which is helpful for oocyte selection for assisted reproductive technology (ART).
Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome
Authors: Ameer Guillermo , Wang Xinlong , Li Yiming , Lin Zitong , Pla Indira , Gajjela Raju , Mattamana Basil , Joshi Maya , Liu Yugang , Wang Huifeng , Zun Amy , Wang Hao , Wai Ching , Agrawal Vasundhara , Dunton Cody , Duan Chongwen , Jiang Bin , Backman Vadim , He Tong Chuan , Reid Russell , Luo Yuan 
Published: January 2025

Abstract

Nuclear morphology, which modulates chromatin architecture, plays a critical role in regulating gene expression and cell functions. While most research has focused on the direct effects of nuclear morphology on cell fate, its impact on the cell secretome and surrounding cells remains largely unexplored, yet is especially crucial for cell-based therapies. In this study, we fabricated implants with a micropillar topography using methacrylated poly(octamethylene citrate)/hydroxyapatite (mPOC/HA) composites to investigate how micropillar-induced nuclear deformation influences cell paracrine signaling for osteogenesis and cranial bone regeneration. In vitro, cells with deformed nuclei showed enhanced secretion of proteins that support extracellular matrix (ECM) organization, which promoted osteogenic differentiation in neighboring human mesenchymal stromal cells (hMSCs). In a mouse model with critical-size cranial defects, nuclear-deformed hMSCs on micropillar mPOC/HA implants elevated Col1a2 expression, contributing to bone matrix formation, and drove cell differentiation toward osteogenic progenitor cells. These findings indicate that micropillars not only enhance the osteogenic differentiation of human mesenchymal stromal cells (hMSCs) but also modulate the secretome, thereby influencing the fate of surrounding cells through paracrine effects.
Evaluation and Enhancement of Large Language Models for In-Patient Diagnostic Support
Authors: Yuan Yixuan 
Published: January 2025

Abstract

In-patient diagnosis demands complex clinical decision-making based on comprehensive patient information, posing critical challenges for clinicians. Despite advancements in large language models (LLMs) in medical applications, limited research focused on artificial intelligence (AI) in-patient diagnostic support systems, due to the lack of large-scale patient datasets. Moreover, existing medical benchmarks typically concentrated on medical question-answering and examinations, ignoring the multifaceted nature of clinical decision-making in in-patient settings. To address these gaps, we first developed the In-Patient Diagnostic Support (IPDS) benchmark from the MIMIC-IV database, encompassing 51,274 cases across nine departments and 17 major disease categories alongside 16 standardized treatment pathways. Then, we proposed the Multi-Agent In-patient Diagnostic Support (MAIDS) framework, including a triage agent managing the patient admission flow, a clinician agent for each department serving as the primary decision maker, and a chief agent for each department overseeing disease assessments and treatment pathways. Experiments in disease assessment accuracies showed MAIDS improved by 20.70% compared to the state-of-the-art LLM. We also found MAIDS demonstrated significant clinical compliance, outperforming three board-certified clinicians by 2%-4%, establishing a foundation for in-patient diagnostic support systems.
Habenula neural circuitry drives negative self-cognitions
Authors: Kung Po-Han , Greaves Matthew , Guerrero-Hreins Eva , Harrison Ben , Davey Christopher , Felmingham Kim , Carey Holly , Sumithran Priya , Brown Robyn , Moffat Bradford , Glarin Rebecca , Steward Trevor 
Published: January 2025

Abstract

Self-related cognitions are integral to personal identity and psychological wellbeing. Persistent engagement with negative self-cognitions can precipitate mental ill health; whereas the ability to restructure them is protective. Here, we leverage ultra-high field 7T fMRI and dynamic causal modelling to characterise a negative self-cognition network centred on the habenula – a small midbrain region linked to the encoding of punishment and negative outcomes. We model habenula effective connectivity in a discovery sample of healthy young adults (n = 48) and in a replication cohort (n = 56) using a novel cognitive restructuring task during which participants repeated or restructured negative self-cognitions. The restructuring of negative self-cognitions elicits an excitatory effect from the habenula to the posterior orbitofrontal cortex that is reliably observed across both samples. Furthermore, we identify an excitatory effect of the habenula on the posterior cingulate cortex during both the repeating and restructuring of self-cognitions. Our study provides the first evidence in humans demonstrating the habenula’s contribution to processing self-cognitions. These findings yield novel insights into habenula’s function beyond processing external reward/punishment to include abstract internal experiences.
A binary merger product as the direct progenitor of a Type II-P supernova
Authors: Niu* Zexi , Sun* Ning-Chen , Zapartas* Emmanouil , Souropanis Dimitris , Cui Yingzhen , Maund Justyn R. , Andrews Jeff J. , Briel Max M. , Fraser Morgan , Gossage Seth , Kruckow Matthias U. , Liotine Camille , Liu Zhengwei , Srivas Philipp M. , Teng Elizabeth , Wang Xiaofeng , Yang Yi , Liu Jifeng 
Published: January 2025

Abstract

Type II-P supernovae (SNe II-P) are the most common type of core-collapse SNe in the local Universe. The progenitors of SNe II-P have been directly observed in fortuitous pre-explosion images with effective temperatures and luminosities consistent with red supergiants (RSGs). For a long time such RSGs were believed to originate from single stars. Recent binary population synthesis, however, predict that many observed SNe II-P should actually arise from interacting binaries. This binary progenitor channel still lacks observational evidence since it is difficult to distinguish whether a detected progenitor comes from the single or binary star system simply based on its appearance in pre-explosion images. In this work, we report the discovery of a RSG progenitor of the Type II-P SN 2018gj. While the effective temperature and luminosity are similar to those of other SN II-P progenitors, it is located in a very old environment and the short plateau of the SN light curve suggests a very low-mass H-rich envelope. These characteristics are best explained if the progenitor is the merger product of a close binary system, in which the progenitor increased its He-core mass but lost much of its H-rich envelope during the back-and-forth mass transfer with a binary companion before merging. Similar analysis for a sample of nearby SNe II-P shows that at least 18–24% of them are likely to originate from binary progenitors. Our discovery provides the first compelling observational evidence that interacting binaries are a viable and potentially significant channel for SN II-P progenitors.

*These authors contributed equally: Zexi Niu, Ning-Chen Sun, Emmanouil Zapartas.
Matrix Plainification Leads to High Thermoelectric Performance in Plastic Cu2Se/SnSe Composites
Authors: Tang Guodong , Ying Pan , Jian Qingyang , Gong Yaru , Song Tong , yang yuxuan , Geng Yang , Huang Junquan , Sun Rongxin , Chen Chen , Shen Tao , Li Yanan , Dou Wei , Liang Congmin , Liu Yuqi , Xiang Deshang , Feng Tao , Zhang Yongsheng , Song Kun , Zhang Yang , Wu Haijun 
Published: January 2025

Abstract

Thermoelectric technology exhibits significant potential for applications in power generation and electronic cooling. In this study, we report the achievement of exceptional thermoelectric performance and high plasticity in stable Cu2Se/SnSe composites. A novel matrix plainification strategy was employed to eliminate lattice vacancies within the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in a marked improvement in carrier mobility. This increase in carrier mobility corresponds to a substantial enhancement of the power factor. Furthermore, the presence of quasi-coherent interfaces induces strong phonon scattering, which effectively reduces lattice thermal conductivity without compromising carrier mobility. Consequently, an outstanding figure of merit (ZT) of 3.3 was attained in the Cu2Se/SnSe composite. Additionally, the presence of high-density nanotwins imparts remarkable plasticity to the composite, yielding a compressive strain of 12%. The secondary phase contributes to the stability of the composite by hindering the extensive migration of Cu ions through bonding interactions. Our findings present a novel strategy for significantly enhancing the thermoelectric performance of composite semiconductors, with potential applicability to other thermoelectric systems.