bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentration levels of VOCs in ambient air and health assessment of respiratory diseases in petrochemical cities in western China
Authors: Chang Lu , Wang Xia , Ding Haixia , Zhou Yian 
Published: September 2023

Abstract
99 Volatile Organic Compounds (VOCs), except aldehydes and ketones, were measured in both PAMS and TO-15 methods in urban and suburban areas of Lanzhou, a petrochemical industry city located in northwest China, between 2021 and 2022. The collected data was analyzed to investigate the seasonal trends in air pollution and its correlation with respiratory diseases in Lanzhou. The average annual concentrations of VOCs were found to be 121 ppbv for urban living areas, 165 ppbv for industrial areas, and 114 ppbv for background areas, with industrial areas having the highest concentration. The VOCs comprise various organic compounds, including alkanes, olefins, halogenated hydrocarbons, and aromatic hydrocarbons, which serve as organic tracers of specific marker molecules or their sources. Using principal component analysis, the species were grouped by the maximum variance method, and the VOCs concentration levels were scored for different regions. The associated changes were then calculated based on the number of respiratory morbidity cases reported from public health hospitals in each region. The results indicate association between VOCs concentration levels and the onset of respiratory illnesses during the fall and winter seasons. Thus, reducing the emissions of VOCs during the fall and winter months can effectively mitigate the public health risks associated with respiratory illnesses.
Theoretical and experimental studies on sulfasalazine interactions with poly (lactic acid): Impact of hydrogen bonding and charge transfer interactions on molecular structure, electronic and optical properties
Authors: Safa Azam Naderi , Sheibani Ali , Baei Mohammad T. , Sayyad-Alangi S. Zahra 
Published: September 2023

Abstract
In this study, we investigated the interaction of sulfasalazine (SSZ) through different functional groups with poly (lactic acid), (PLA), in the chloroform phase through density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods. Our calculation results based on binding energy and thermodynamic parameters indicate that the interaction between SSZ and PLA in state I (-0.71 eV) via hydrogen double bond is stronger than in states II (-0.64 eV) and III (-0.51 eV). UV-Vis spectra of SSZ interaction with PLA are determined using theoretical techniques in combination with a comparative analysis of carrier and drug spectra in the chloroform phase. The interaction of SSZ with PLA leads to increased dipole moment and higher solubility with more negative Gibbs free energy (∆Gsolv) and energy gap (Eg) values. The theoretical calculations are made in order to shed light on the complex processes that resulted in the minimal variations in the maximum absorption wavelength seen in the experimental spectra. Theoretical UV-Vis analysis demonstrates SSZ interaction with PLA happens in the ultraviolet region with a maximum absorption peak at 380 nm, which is close to experimental UV-Vis analysis. The experimental and theoretical Infrared (IR) spectra demonstrated that the structure of PLA was altered in the presence of SSZ.
Effect of Lupinus albus conglutin gamma protein on experimentally induced diabetes in rats
Authors: Bhieldeen Marwa , Moustafa Yasser M. , Tawfik Afaf A. , Elsayed Sami M. , El-shaarawy Fatma F. 
Published: September 2023

Abstract
Early insulin resistance and a progressive loss of pancreatic β cell function combine to cause type 2 diabetes (T2D), which leads to insufficient insulin production followed by hyperglycemia. Purified from Lupinus albus seed, conglutin gamma (Cγ) is a protein that lowers blood sugar. The primary function of adipocytokines, hormones released by adipose tissue, is to alert important organs to maintain metabolic balance. This study aimed to identify and compare the role of Cγ and glimepiride in controlling hyperglycemia, insulin secretion, insulin resistance and hyperlipidemia in high-fat diet and low- dose streptozotocin (STZ) induced T2D experimental rats through affecting the expression of various adipocytokines Male Spargue Dawely rat groups were divided into normal, Cγ control, T2D control, and four T2D groups that received Cγ (30, 60, and 120 mg/Kg) and Glimepiride (0.1 mg/kg) treatments. Administration of Cγ successfully eliminated hyperglycemia and increased insulin secretion and sensitivity. Additionally, when compared to (STZ + HFD) control rats, treatment with Cγ improved the expression of leptin, adiponectin, and their blood concentration, as well as the activity of the enzyme chitotriosidase. It also significantly decreased the expression of apelin, NAMPT and RBP4. The present data suggests that Cγ has an effective role on controlling hyperglycemia induced by diabetes through amelioration of leptin, adiponectin, liver enzyme levels, lipid profile and metabolic syndrome.
Research on performance of folding ornithopter based on gun-mounted compound catapult
Authors: ZHANG Chunpeng , SHAO Weiping , HAO Yongping , LIU Ziwei , Zhaowei PENG 
Published: September 2023

Abstract
In order to improve the flight of bionic ornithopter based on hand throwing, a medium-sized bionic ornithopter with foldable wings and its ejection device are designed. The three-dimensional model of the ornithopter and the gun is established, and the aerodynamic performance of the system is analyzed by fluent software. The system device carried out firing experiments under different ejection angles, different ejection pressures, different air humidity and different ambient temperatures. In the process of ejecting the bird gun from the muzzle to the maximum flight height, the loading shell covering the bird body would be ejected under the combined action of the air flow and the flapping wing extension. In order to avoid interference with the bird body after the ejection of the loading shell shell, So you need to meet a certain initial flight speed of the bird. Experiments show that when the incoming flow velocity is 10m/s, the foldable orphewing aircraft can reach the optimal flight height and spread attitude under the body elevation Angle of 45°, the air pressure 0.6MPa in the cylinder, the air humidity of 50%rh and the body sensing temperature of 24℃. At the same time, the initial flight speed of the bird can reach 19.4m/s, which satisfies the basic conditions for the flight of the bird.
Evaluation of Anti-diabetic Activity of Isolated Fractions of Aegle Marmelos
Authors: Kumar.Ch Sampath , Pandian P. , A.Madhukar  
Published: September 2023

Abstract
The aim of this study was to evaluate the anti-diabetic activity of isolated fractions from Aegle marmelos. To achieve this, experiments were conducted on rats with induced diabetes using STZ. The isolated fractions were administered to the rats at different doses, specifically 20 mg/kg and 40 mg/kg, over duration of 28 days.
Using the accu-chek active test meter, blood glucose levels were measured to assess the anti-diabetic effects of the isolated fractions. Additionally, a comparison was made with the standard anti-diabetic medication, pioglitazone, which was given to another group of rats at a normal dose of 2.7 mg/kg.
The results of this study indicated that the isolated fractions of Aegle marmelos exhibited considerable anti-diabetic activity. Furthermore, the study also included acute and sub-acute toxicology assessments to determine the safety of the isolated fractions at higher doses. The acute toxic study demonstrated that Aegle marmelos was photochemically safe up to 300 mg/kg, while the sub-acute toxic study showed safety up to 1000 mg/kg.
Overall, these findings suggest that the isolated fractions of Aegle marmelos have promising anti- diabetic potential, making them worthy candidates for further investigation and potential therapeutic applications.
The Sources, Diffusion, and Health Risks of Polycyclic Aromatic Hydrocarbons in Water and Sediment of a Typical Underground River in South China
Authors: Lu Li , Chen Yudao , Zou Shengzhang , Wang Zhe , Fan Lianjie 
Published: September 2023

Abstract

Underground rivers serve as the primary source of drinking water in the karst area in South China and support their development. However, the aquifer structure of the karst region makes it easy for PAHs (polycyclic aromatic hydrocarbons) to enter underground rivers, which causes heavy pollution and affects water quality and safety. This study chose the Qingshuiquan underground river in Nanning City as a representative to reveal the sources, diffusion, and health risks of PAHs in water and sediment of underground rivers. The results showed that the ∑16PAHs concentration ranges in groundwater and sediment were 294.44-489.91 ng/L and 380.13-1141.97 ng/g respectively. From the upstream to the downstream, PAH concentrations increased, and the proportion of PAHs with lower rings decreased. PAHs came from three sources: the high-temperature combustion of grass, wood, and coal in the upper reaches, petroleum in the middle reaches, and coal and oil combustion in the lower reaches. As ring numbers of PAHs and organic carbon content increased, PAHs were more likely to disperse into sediment. Sediment turned from source to sink, and groundwater from sink to source. PAHs in groundwater posed only carcinogenic health risks and zero non-carcinogenic health risks, with adults suffering from higher risks than children, and dermal contacts riskier than ingestion. The levels of carcinogenic health risks differed spatially, with risks in the downstream significantly higher than those in the midstream and upstream. PAH monomers such as BaP and DaA require close attention. These results can provide scientific evidence for POPs (persistent organic pollutants) prevention and control in the karst water environment.
Chewing with a cleft palate: a randomized controlled trial. Effect of timing of surgical closure of the palate on mastication in infants with clefts.
Authors: Guillaume CHAL , Verhoeven MMR , Eligh AM , Haverkamp SJ , Eijkemans RMJC , Molen AB Mink van der , Kon M , Breugem CC 
Published: September 2023

Abstract

Objectives- To evaluate the timing of surgical closure of the palate on overall masticatory function in infants with cleft lip- and/or palate (CL/P).
Materials and Methods- We performed a two-arm longitudinal observational study including 60 children with CL/P treated by the cleft-team in the Wilhelmina Children’s Hospital, University Medical Center Utrecht, The Netherlands. The study population was divided in two groups based on timing of the palatal closure at respectively 6-8 (group A) and 10-12 (group B) months of age. Measurement was performed at the age of 9, 13 and 17 months using the Mastication Observation and Evaluation (MOE) instrument, which scored the tongue protrusion, lateral tongue movement, munching, jaw movement, chewing duration, loss of food or saliva, number of swallows, fluency and coordination of chewing in all subjects.
Results- There was no statistically significant difference in total MOE score between group A and B. Group B performed significantly better regarding lateral tongue movement at the age of 17 months in comparison to individuals with early palatal closure (group A mean = 2.45; SD = 0.506, group B mean = 2.72; SD = 0.528).
Conclusions- Early palatal closure does not result in a better overall masticatory function in children with CL/P at the age of 9, 13 and 17 months, when assessed with the MOE instrument.
Clinical Relevance- Study’s that investigate the overall mastication performance in children with CL/P are lacking. Our study is the first to evaluate this treatment outcome regarding the timing of palatoplasty.
Trial Registration Number
The CLEFED study was approved by the Medical Ethics Committee of the University Medical Center Utrecht, The Netherlands (registration no: NTR3275).
Date of registration: November 2011
First proteome analysis of poplar-type propolis
Authors: Šuran Jelena , Radić Božo , Silva Dilza Trevisan , Cindrić Mario , Hozić Amela 
Published: September 2023

Abstract
Propolis is a natural mixture of honeybee-released and plant-derived compounds produced by honeybees. Poplar propolis is rich in bioactive polyphenolic compounds, and due to its many health benefits, it is commonly used as a food supplement or functional food ingredient. However, it is the only honeybee product whose proteome hasn’t been analyzed. Here, we report a first proteome analysis of poplar-type propolis, a challenging glue-type resinous sample for protein characterization. Raw propolis mixture was precipitated with cold acetone to obtain the protein fraction. Proteins were digested with trypsin, and generated peptides were analyzed on nano-ESI-qTOF SYNAPT G2-Si mass spectrometer (MS) by data-independent acquisition (DIA) and data-dependent acquisition (DDA). Identified peptides and inferred proteins suggest the presence of new bioactive molecules as components of propolis. The poplar-type propolis proteome is composed of a mixture of proteins from Apis and Populus genera. This is the first-ever report of the proteome of any type of propolis.
GNSS signal multi-frequency carrier phase asynchronous joint tracking
Authors: Wang Dun , Liu Peng , Peng Bo , Liu Tong , Chen Yaohui , Zhang Shuangna , Dong Qijia 
Published: September 2023

Abstract

Many studies have been done and proved that jointly tracking GNSS multi-frequency signals transmitted from the same satellite can improve the sensitivity and robustness of signal tracking. However, current work has not elucidated the mechanism of joint tracking loop operation by in-depth quantitative theoretical analysis. Thus a synchronous-input asynchronous-update processing method for multi-frequency carrier phase joint tracking is proposed, which is applicable to contemporary mainstream GNSS receivers adopting an asynchronous signal correlation reception structure. In this paper, a linearized mathematical model of the joint tracking loop is built, a thermal noise jitter calculation equation for the joint tracking loop is derived, the dynamic stress response characteristics of the joint tracking loop are examined, and the loop design requirements for eliminating the influence of inter-frequency frequency bias are clarified. Monte Carlo simulations and preliminary field tests validate the theoretical results using the B1C and B2a pilot signals of the MEO satellite in the BeiDou satellite navigation system (BDS). Experimental results show that the carrier phase tracking threshold of the B1C and B2b signals can be reduced by about 1 dB and 3.5 dB, respectively.
Estimation of the Ku-band accuracy of a simplified equivalent circuit for a Schottky gate SiN/AlGaN/GaN HEMT
Authors: Garber Gennadiy 
Published: September 2023

Abstract
We investigate the accuracy of the internal FET equivalent circuit with only one nonlinear element – the channel current generator given by the Curtice-Ettenberg model. The parameters of this simplified equivalent circuit are assigned using the 2D quasi-hydrodynamic simulations taking into account the electron velocity overshoot. Wecalculated the power-added efficiency, transducer power gain, and other amplifier parameters as functions of the maximum available power of an 18-GHz input generator by three methods: using the full 2D model for the internal FET and the large-signal equivalent circuit – complete and simplified. Comparison of these power characteristics indicates the suitability of the simplified equivalent circuit for analysis and design of Ku-band power amplifiers based on the Schottky gate AlGaN/GaN HEMT passivated with the silicon nitride layer. Since this equivalentcircuit is implemented in various commercial software packages for analysis and design of RF and microwave devices, results of the 2D quasi-hydrodynamic simulations can be used in these packages. The software of this article makes it possible to evaluate the influence of the design features of a transistor on its electrical properties already at the design stage. As an example, we give the power characteristics calculated for two values of the dielectric constant of the passivation layer (6.5 and 1); the linear interpolation and extrapolation methods allow to talk about the transistor electrical properties also at other values of the dielectric constant. We also evaluate the effect of the passivation on the avalanche multiplication of charge carriers in the semiconductor, that is, on the validity of excluding the avalanche current generator from the feedback branch of the large-signal equivalent circuit. The validity of other simplifications of the equivalent circuit is also discussed.
Intrascleral (Yamane Technique) Versus Trans-scleral (ab externo Technique) Intraocular Lens Implantation in Pediatric Aphakia: Prospective Randomized Study
Authors: Ahmed Amany E. , Hagras Sherein M. , Gaafar Walid M. , Laimon Dina N. , Zaki Nashaat Sh. , Elhesy Abdelmonaem A. , Ellayeh Adel E. 
Published: September 2023

Abstract
Purpose
to compare between intrascleral (Yamane Technique) and trans-scleral (ab externo technique) posterior chamber intraocular lens (PCIOL)implantation in cases of pediatric aphakia.
Patients and methods:
a prospective interventional study included 20 aphakic eyes < 18 years old with insufficient capsular support. Patients were randomly assigned into two groups; group (1) underwent sutureless intrascleral IOL implantation using Yamane technique and group (2) underwent trans-scleral IOL implantation (ab externo technique). Outcome measures included visual acuity (uncorrected UCVA& best corrected BCVA), astigmatism (corneal and IOL-induced), Keratometric readings, IOL state and any developed surgical complications. Patients were followed for at least 6 months.
Results
There was a statistically significant improvement in UCVA and BCVA at 6th month compared to preoperative values, without significant difference between the 2 groups. Corneal astigmatism was higher in group (2) whereas IOL-induced astigmatism was higher in group (1) with no statistically significant difference between the 2 groups in both parameters. IOL tilt was higher in group (1), but the difference was not significant. There was a statistically significant higher adjusted post-operative K2-reading in group (2) with no difference in adjusted post-operative K1-reading between the two groups. There was no statistical difference between the 2 groups regarding postoperative complications.
Conclusion
Both techniques for scleral fixation PCIOL resulted in comparable visual outcomes in pediatric cases with aphakia. Sutureless intrascleral fixed IOL results in lower corneal astigmatism with good IOL stability and centration.
Targeted regulation of miR-154-5p/Cullin-2 pathway by hsa_circ_0000276 in human papillomavirus type 16 positive cervical cancer cells
Authors: Zhao Weihong , Wen Songquan , Wang Xiuting , Wang Jingfang , Zhang Lili , Wang Tong 
Published: September 2023

Abstract
Purpose
To investigate the role of targeting and silencing miR-154-5p by hsa_circ_0000276 in regulating Cullin-2 (CUL2) expression in human papillomavirus type 16 (HPV16)-positive cervical cancer (CC) cells.
Methods
Cervical tissues of individuals with normal cervix (NC), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and HPV16-CC were collected. hsa_circ_0000276 level in cervical tissues and cell lines was determined using real-time fluorescence quantitative PCR (qRT-PCR). A shRNA expression vector was constructed for the circular RNA—hsa_circ_0000276. CC cells were transfected with sh-hsa_circ_0000276 or sh-NC. The cell counting kit-8, scratch healing, transwell migration assays, and flow cytometry were used to assess the proliferation, migration, invasiveness, cell cycle distribution, and apoptosis of cells, respectively. Mechanistically, the targeting and regulatory activity between hsa_circ_0000276 and miR-154-5p were confirmed using the Dual-Luciferase Reporter gene assay and rescue experiments.
Results
The expression of hsa_circ_0000276 was significantly higher in CC tissues and cells. Functionally, knockdown of sh-hsa_circ_0000276 decreased proliferation, migration, and invasiveness, slowed the cell cycle, and enhanced apoptosis. Mechanistically, hsa_circ_0000276 could bind miR-154-5p and prevent miR-154-5p from reducing the levels of CUL2. Notably, the application of miR-154-5p inhibitor significantly rescued hsa_circ_0000276-mediated tumorigenesis.
Conclusion
hsa_circ_0000276 is upregulated in HPV16-positive CC and promotes CC progression by regulating the miR-154-5p/CUL2 pathway, suggesting that it may be a target of CC treatment.
Experimental and Numerical Evaluation of Polymer Electrolyte Fuel Cells with Porous Foam Distributor
Authors: Heidary Hadi , Steinberger-Wilckens Robert , Jahromi Mahbod Moein , El-kharouf Ahmad 
Published: September 2023

Abstract

This paper presents a comprehensive evaluation of metal foam employment within polymer electrolyte fuel cells (PEFCs) and compares it with conventional serpentine channels from both experiment viewpoints and computational fluid dynamics simulation. The experiments are designed to study the effects of material, area density, compression ratio, and final thickness of metal foam. Additionally, the influence of housing plate material and relative humidity (RH) is also tested for the first time. The results reveal that at RH = 75–100%, the best distributor design is nickel foam with a compression ratio of 70%, a final thickness of 0.5mm, and SS-304 housing plate, which delivers 3110 mA cm− 2 as limiting current density that is scarce in the literature. The PEFC with this foam distributor shows a 10% improvement in maximum power density and 45% in limiting current density compared to the serpentine channel case. While at RH = 30%, the same foam flow field with a final thickness of 1mm is a superior option. The experiments also indicate that maximum power density increases by 23% as the compression ratio rises from 0 to 70%, while reducing final thickness from 1 to 0.5 mm causes a 19% enhancement in cell performance. Simulation results reveal that metal foam is more successful in evenly reactant distribution so that the average oxygen mass fraction at the cathode catalyst layer is increased by 38% in the metal foam case compared to the serpentine channel.
Are there common tacit drivers for European Recovery and Resilience grants distribution and allocation in Health?
Authors: Vieira João , Marques João , Tavares Aida Isabel 
Published: September 2023

Abstract
This work aims to identify drivers for the distribution and allocation of EU Recovery and Resilience Facility (RRF) grants for Health. To achieve this, 29 variables were collected and divided into four domains. A Principal Component Analysis was done, and a linear regression analysis was estimated to test the existence of drivers of RRF distribution and allocation. Our main findings demonstrate that factors like avoidable mortality and self-reported poor health status drive grants per capita for Health, while Bismarck-type health systems, number of beds and health expenditures discourage the allocation of those grants. We have also found that certain political characteristics, such as governments constituted by a single party or a majority in parliament, may affect the distribution and allocation of RRF money for health.