bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation between the hemoglobin-to-red cell distribution width ratio and all-cause mortality in patients with malignant tumors and sepsis: A retrospective cohort study using the MIMIC-IV database
Authors: Zhang Shu , Xu Shan , Liao Rui , Qin Kaixiu 
Published: June 2023

Abstract

Objective
The aim of the study was to investigate the correlation between the hemoglobin-to-red cell distribution width ratio (HRR) and all-cause mortality in patients with malignant tumors and sepsis.

Methods
All patients who met the inclusion criteria of the Medical Information Mart for Intensive Care (MIMIC)-IV were selected and divided into four groups according to the quartile range of HRR distribution. Kaplan-Meier (K-M) analysis was used to plot the 28-day survival curve, and the log-rank test was used to compare the prognosis in each HRR group. A Cox proportional hazards regression model was used to evaluate the prognosis of HRR as both a continuous and categorical variable, and a restricted cubic spline was used to study the effect of HRR, as a continuous variable, on the mortality in patients with malignant tumors and sepsis. Interaction and subgroup analyses were performed to evaluate the consistency of correlations.

Results
A total of 3926 patients were included in the study, including 934 patients in the HRR ≤ 4.97 group, 988 patients in the 4.97 < HRR ≤ 6.26 group, 1005 patients in the 6.26 < HRR ≤ 7.84 group, and 999 patients in the HRR ≥ 7.84 group. According to the K-M analysis, the 28-day survival rate was the lowest in the HRR ≤ 4.97 group (59.53%), and there were significant differences in survival rates among different HRR levels (P < 0.001). The Cox proportional hazards regression model found that after adjusting for various potential confounding factors, HRR was negatively correlated with 28-day and 365-day mortality, and the risk of death in the HRR ≥ 7.84 group was significantly lower than that in the HRR ≤ 4.97 group (P = 0.030 and P = 0.008, respectively). The restricted cubic spline plot revealed a linear and negative relationship between the HRR and the 28-day and 365-day mortality rates. Subgroup analysis revealed an interaction between HRR, blood urea nitrogen, and SAPS II scores (P = 0.010 and P = 0.048, respectively).

Conclusion
Low HRR is an independent risk factor for all-cause mortality in patients with malignant tumors and sepsis and could be used as a prognostic indicator for these patients.
Radiofrequency localization of nonpalpable breast cancer in a multicentre prospective cohort study: feasibility, clinical acceptability, and safety
Authors: Christenhusz Anke , den Dekker Bianca M. , van Dalen Thijs , Jongen Lisa , van der Schaaf Margreet C. , Alic Lejla , ten Haken Bennie , Pijnappel Ruud M. , Dassen Anneriet E. 
Published: June 2023

Abstract
Purpose
In breast conserving surgery, accurate lesion localization is essential for obtaining adequate surgical margins. Preoperative wire localization (WL) and radioactive seed localization (RSL) are widely accepted methods to guide surgical excision of nonpalpable breast lesions but are limited by logistical challenges, migration issues, and legislative complexities. Radiofrequency identification (RFID) technology may offer a viable alternative. The purpose of this study was to evaluate the feasibility, clinical acceptability, and safety of RFID surgical guidance for localization of nonpalpable breast cancer.

Methods
In a prospective multicentre cohort study, the first 100 RFID localization procedures were included. The primary outcome was the percentage of clear resection margins and re-excision rate. Secondary outcomes included procedure details, user experience, learningcurve, and adverse events.

Results
Between April 2019 and May 2021, 100 women underwent RFID guided breast conserving surgery. Clear resection margins were obtained in 89 out of 96 included patients (92.7%), re-excision was indicated in three patients (3.1%). Radiologists reported difficulties with the placement of the RFID tag, partially related to the relatively large needle-applicator (12-gauge). This led to the premature termination of the study in the hospital using RSL as regular care. The radiologist experience was improved after a manufacturer modification of the needle-applicator. Surgical localization involved a low learning curve. Adverse events (n = 33) included dislocation of the marker during insertion (8%) and hematomas (9%). The majority of adverse events (85%) occurred using the first-generation needle-applicator.

Conclusion
RFID technology is a potential alternative for non-radioactive and non-wire localization of nonpalpable breast lesions.
Agency and Intra-textual co-creation in Punchdrunk Enrichment’s Immersive Story Worlds for Children
Authors: Osborne Gareth 
Published: June 2023

AbstractRecent immersive theatre practices being developed by UK theatre companies invite children to believe that a book story has come to life and is really happening to them within their school environment. The thrill of being able act within a story motivates children’s embodied agency to physically explore an immersive set installation and acts of creative writing performed during the story experience, which allow children to co-create the narrative alongside the adult practitioners. These acts are fictionalised into the narrative frame of the children as heroic story writers, offering new perspectives on how child co-creation of adult narratives can be enabled intra-textually, within the bounds of the adult-initiated story, rather than extra-textually after it has finished, as is the case with fan fiction. However, it raises questions about the nature and limits of this co-creative agency the experiences purport to elicit from their child participants, especially in terms of their critical agency to manipulate fictional devices presented to them through such a hyper-real aesthetic. Drawing on theories of children’s literature and participatory performance, this article argues that it is the way these immersive productions uncannily overlay real and fictional temporalities that enables the child participants’ critical agency within them. Approaches for further participatory, practice-based research in this understudied corner of children’s reading universes are suggested for harnessing the potential of immersive story worlds to generate research data from within children’s first aesthetic engagement with stories.
Social Skills and Cognitive Training to Support Work-Related Skills and Job Placement in a Group of Autistic Adults
Authors: Brighenti S. , Mustacchia L. , Cicinelli G. , Chieregato S. , Comella C. , Torrero L. , Granata F. , Keller R. 
Published: June 2023

AbstractAutistic people may have difficulties in finding and keeping a job. Studies highlight that only 34% of autistic people are employed compared to 54% of people with disability. 58% of people with ASD have never had a job. Social cognition and cognitive strains may also have a significant impact on working life. The primary goal of our project is supporting autistic people through a training program focused on neuropsychological and social skills training to improve participant’ job skills. Through an Individual Placement and Support model the project involved various Partners to guide, identify skills and interests, provide cognitive and psychological support for autistic people. Results highlighted neuropsychological training efficacy, especially in inhibitory control and good rate of employment status at the end of the project. Findings are encouraging and underline the importance of a multidisciplinary approach to support autistic people in their work life considering their expectations, needs and inclinations.
Identifying Central Negative Thoughts Using Experience Sampling and Network Analysis
Authors: Marian Ştefan , Sava Florin Alin 
Published: June 2023

Abstract
Purpose
Network analysis has promised to inform clinical practice about what should be prioritised in treating different psychological disorders. However, the pure phenomenological approach adopted by network analysis did not help advance this goal considerably. We propose a theoretical approach based on the cognitive model of psychopathology.

Method
We used a multivariate vector-autoregression model to analyse the networks of anxious symptoms, depressive symptoms, and negative automatic thoughts. In a preliminary study, we identified the most common negative thoughts and then monitored them alongside symptoms of anxiety and depression in a sample of undergraduate students three times per day for three weeks.

Results
Results revealed that negative thoughts have a high bridge outdegree in the temporal network (predict the occurrence of symptoms), while symptoms have a high bridge outdegree (are predicted by thoughts). Thoughts related to self-criticism, like “There is something wrong with me”, were the most central for both anxiety and depression and could be considered priority targets for cognitive interventions.

Conclusions
Adopting a theoretical approach has proven helpful in providing concrete targets for therapy instead of just identifying central symptoms, as it is typically done in network studies. Future network studies could also consider adopting an approach based on a psychotherapeutic theory about the aetiology of psychopathology.
Candrakīrti on the Use and Misuse of the Chariot Argument
Authors: Jones Dhivan Thomas 
Published: June 2023

AbstractThe publication in 2015 (ed. Li) of Chap. 6 of the rediscovered Sanskrit text of Candrakīrti’sMadhyamakāvatāra(MA) allows us to witness more directly Candrakīrti’s careful and deliberate critique of the ‘chariot argument’ for the merely conventional existence of the self in Indian Abhidharmic thought. I argue that in MA 6.140–141, Candrakīrti alludes to the use of the chariot argument in theMilindapañhaas negating only the view of a permanent self (compared to an elephant), rather than negating ego-identification (compared to a snake in its hole). In contrast to this misuse of the chariot argument, in MA 6.150–165 Candrakīrti uses the chariot argument as an allegory to enable the meditator to refute the basis of ego-identification in seven ways. Candrakīrti’s use of the chariot argument does not establish any theory about the self or not-self, but acts as a guide to meditation as part of philosophy as a spiritual practice with the goal of liberation.
Achieving SDG 14 in an equitable and just way
Authors: Haas Bianca 
Published: June 2023

AbstractSustainable Development Goal (SDG) 14—life below water—significantly elevated global awareness of the importance of the oceans. It is also a key SDG for achieving the other 16 goals and targets. However, the global community is a long way off achieving this goal and serious equity concerns have been raised in the context of SDG 14. This perspective paper provides a summary of the overall progress, or the lack thereof, in achieving SDG 14 and examines some of the obstacles which might undermine the achievement of this goal, such as weak indicators and a lack of recognition of Indigenous and traditional knowledge. This paper also provides recommendations on how countries and stakeholders could take a step closer to achieving SDG 14. Overall, reiterating the calls of global experts, it is imperative that SDG 14 is implemented in an equitable and just way, without further discriminating against developing countries and vulnerable communities.
An atypical expression of core α-Dystroglycan and Laminin-α2 in skin fibroblasts of patients with congenital muscular dystrophies
Authors: Sabry Sahar , Issa Mahmoud Y , Abdel-Hamid Mohamed S , Eissa Noura R , Abdel-Ghafar Sherif F , Ibrahim Mona M , Zaki Maha S 
Published: June 2023

Abstract
Background
Congenital muscular dystrophies (CMDs) result from genetically inherited defects in the biosynthesis and/or the posttranslational modification (glycosylation) of laminin-α2 and α-dystroglycan (α-DG), respectively. The interaction between both proteins is responsible for the stability and integrity of the muscle cell. We aimed to study the expression profiles of both proteins in two classes of CMDs.

Subjects and methods
Whole-exome sequencing (WES) was done for four patients with neuromuscular manifestations. The expression of core α-DG and laminin-α2 subunit in skin fibroblasts and MCF-7 cells was assessed by western blot.

Results
WES revealed two cases with nonsense mutations; c.2938G > T and c.4348 C > T, in LAMA2 encodes laminin-α2. It revealed also two cases with mutations in POMGNT1 encode protein O-mannose beta-1,2-N-acetylglucosaminyltransferase mutations. One patient had a missense mutation c.1325G > A, and the other had a synonymous variant c.636 C > T. Immunodetection of core α-DG in skin fibroblasts revealed the expression of truncated forms of core α-DG accompanied by reduced expression of laminin-α2 in POMGNT1-CMD patients and one patient with LAMA2-CMD. One patient with LAMA2-CMD had overexpression of laminin-α2 and expression of a low level of an abnormal form of increased molecular weight core α-DG. MCF-7 cells showed truncated forms of core α-CDG with an absent laminin-α2.

Conclusion
A correlation between the expression pattern/level of core α-DG and laminin-α2 could be found in patients with different types of CMD.
Propagation of keystone-woody species as a first step in restoration of an overgrazed seasonal dry forest
Authors: Martínez-Gálvez Fernanda , Baskin Carol C. , Croce Johanna , Dalmasso Antonio , Tálamo Andrés 
Published: June 2023

AbstractIn degraded forest ecosystems, reintroduction of keystone-woody species is an important step for restoration because it provides regeneration niches. However, lack of information on how to propagate species restricts the use of native species; specially in tropical dry forests where seed germination is seasonal and is synchronized with the onset of the wet season. We evaluated the dormancy-breaking and germination requirements of nine keystone-woody species from Dry Chaco Forest. Most fresh viable seeds of the keystone species are nondormant, but viability decreases during dry-cold storage restricting the use of some species. Seeds of three keystone species germinated to higher percentages in light than darkness and those of five species germinated equally well in light and darkness; seeds of Castela coccinea germinated to higher percentages in darkness than in light. Alternating vs. constant temperatures had no effect on germination in seven species. Seeds of Anisocapparis speciosa and Cynophalla retusa were nondormant and remained viable for only 1 month during cold-dry storage; and 62–95% of the seeds of the other seven species were nondormant. Dormancy-break was studied in five of the seven species; seeds of four species had physiological dormancy and one had physical dormancy. Dormancy-breaking was promoted by environmental conditions in the habitat, i.e. warm stratification, after seed dispersal. Castela coccinea, Achatocarpus praecox, Mimosa detinens, and Capparicordis tweedieana are the most suitable keystone species for the restoration of overgrazed areas in the Dry Chaco Forest because their seeds germinate to a high percentage and retain viability during dry storage at low temperatures. Seeds of Mimosa detinens and Capparicordis tweedieana required mechanical scarification and 6-weeks of warm stratification, respectively, for dormancy-break.
Bladder perforation as a complication of transurethral resection of bladder tumors: the predictors, management, and its impact in a series of 1570 at a tertiary urology institute
Authors: Osman Yasser , Elawdy Mohamed , Taha Diaa-Eldin , Zahran Mohamed H. , Abouelkheir Rasha T. , Sharaf Doaa Elsayed , Mosbah Ahmed , Ali-El Dein Bedeir 
Published: June 2023

Abstract
Objectives

To report the incidence, predictors, the impact of bladder perforation (BP), and our protocol of management in patients who underwent trans-urethral resection of bladder tumor (TURBT).

Methods

This is a retrospective study, between 2006 and 2020, on patients who underwent TURBT for non-muscle-invasive bladder cancer (NMIBC). Bladder perforation was defined as any full thickness resection of the bladder wall. Bladder perforations were managed based on their severity and type. Small BP with no or mild symptoms were managed with prolongation of urethral catheters. Those with significant extraperitoneal extravasations were managed by insertion of a tube drain (TD). Abdominal exploration was done for extensive BP and all intraperitoneal extravasations.

Results

Our study included 1,570 patients, the mean age was 58 ± 11 years and 86% were males. Bladder perforation was recorded in 10% (n = 158) of the patients. The perforation was extraperitoneal in 95%, and in 86%, the perforation was associated with no symptoms, mild symptoms, or mild fluid extravasation that required only prolongation of the urethral catheter. On the other hand, active intervention was required for the 21 remaining patients (14%) with TD being the most frequent management. History of previous TURBT (p = 0.001) and obturator jerk (p = 0.0001) were the only predictors for BP.

Conclusions
The overall incidence of bladder perforation is 10%; however, 86% required only prolongation of urethral catheter. Bladder perforation did not affect the probability for tumor recurrence, tumor progression nor radical cystectomy.
Equity in mathematics education
Authors: Vithal Renuka , Brodie Karin , Subbaye Reshma 
Published: June 2023

AbstractThis paper reviews research on equity in mathematics education (excluding gender equity) for the period 2017–2022. From the publications identified, five themes were distilled: conceptualizations and framing of equity in mathematics education; research methodologies and researcher positionalities; equity-focused practices, pedagogies and teacher education; equitable mathematics curriculum content, access and pathways; and equity in mathematics education at system levels, nationally and internationally. The review concludes by engaging some of the critique and suggests future directions for research. The research demonstrates that there is growing voice and visibility of equity-focused studies in mathematics education and that conceptualizations of equity have broadened and deepened through an increasing diversity of studies in this area. At the same time, the review also shows the dominance of the Global North in shaping equity discourses and the paucity of research on equity in mathematics education from the Global South.
Thresholds and tipping points are tempting but not necessarily suitable concepts to address anthropogenic biodiversity change—an intervention
Authors: Hillebrand Helmut , Kuczynski Lucie , Kunze Charlotte , Rillo Marina C. , Dajka Jan-Claas 
Published: June 2023

AbstractThresholds and tipping points are frequently used concepts to address the risks of global change pressures and their mitigation. It is tempting to also consider them to understand biodiversity change and design measures to ensure biotic integrity. Here, we argue that thresholds and tipping points do not work well in the context of biodiversity change for conceptual, ethical, and empirical reasons. Defining a threshold for biodiversity change (a maximum tolerable degree of turnover or loss) neglects that ecosystem multifunctionality often relies on the complete entangled web of species interactions and invokes the ethical issue of declaring some biodiversity dispensable. Alternatively defining a threshold for pressures on biodiversity might seem more straightforward as it addresses the causes of biodiversity change. However, most biodiversity change appears to be gradual and accumulating over time rather than reflecting a disproportionate change when transgressing a pressure threshold. Moreover, biodiversity change is not in synchrony with environmental change, but massively delayed through inertia inflicted by population dynamics and demography. In consequence, formulating environmental management targets as preventing the transgression of thresholds is less useful in the context of biodiversity change, as such thresholds neither capture how biodiversity responds to anthropogenic pressures nor how it links to ecosystem functioning. Instead, addressing biodiversity change requires reflecting the spatiotemporal complexity of altered local community dynamics and temporal turnover in composition leading to shifts in distributional ranges and species interactions.
Relevance of Zearalenone and its modified forms in bakery products
Authors: Pfleger Franz , Schwake-Anduschus Christine 
Published: June 2023

AbstractZearalenone is a frequently occurring and well-known mycotoxin developed in cereals before and during the harvest period by Fusarium spp. mainly in maize and wheat. In addition to the main form, various modified forms (phase I and II metabolites) were detected, in some cases in high amounts. These modified forms can be harmful for human health due to their different toxicity, which can be much higher compared to the parent toxin. In addition, the parent toxin can be cleaved from the phase I and II metabolites during digestion. A risk of correlated and additive adverse effects of the metabolites of ZEN phase I and II in humans and animals is evident. ZEN is considered in many studies on its occurrence in grain-based foods and some studies are dedicated to the behavior of ZEN during food processing. This is not the case for the ZEN phase I and II metabolites, which are only included in a few occurrence reports. Their effects during food processing is also only sporadically addressed in studies to date. In addition to the massive lack of data on the occurrence and behavior of ZEN modified forms, there is also a lack of comprehensive clarification of the toxicity of the numerous different ZEN metabolites detected to date. Finally, studies on the fate during digestion of the relevant ZEN metabolites will be important in the future to further clarify their relevance in processed foods such as bakery products.
AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progression
Authors: Ma Peng , Hao Ying , Wang Wei , Zhang Yue-Feng , Yu Kai-Huan , Wang Wei-Xing 
Published: June 2023

AbstractIntrahepatic cholangiocarcinoma (ICC) is a fatal disease and the molecular mechanism of its progression remains unknown. Aurora Kinase B (AURKB) is a central regulator of chromosome separation and cytokinesis and is abnormally expressed in a variety of cancer cells. This research aimed to explore the effect of AURKB in occurrence and metastasis of ICC. We found that AURKB showed a progressive up-regulation pattern from normal bile duct tissue to ICC with high invasion. Our data showed that AURKB significantly promoted ICC cell proliferation, induced epithelial-mesenchymal transition (EMT), migration and invasion through gain- and loss- of function experiments. Invivoresults consistently showed that AURKB up-regulation not only promoted tumor growth, but also promoted tumor metastasis. Importantly, we discovered that AURKB regulates the expressions of EMT-related genes via PI3K/AKT signaling axis. Herein, our results suggest that AURKB induced EMT through the activation of PI3K/AKT signaling pathway is critical to the progression of ICC, which may be a prospective therapeutic treatment for overcoming ICC metastasis and progression.