bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of Type 2 Diabetes Susceptible Gene GCKR Polymorphisms Rs780094 and Rs1260326 to Gestational Diabetes Mellitus: A Meta-Analysis
Authors: Zhang Yuke , Wang Kuangyi , Ji Chenxi , Lin Yansi , Liu Zitong , Chen Jing , Zheng Feifei , Yang Xiaoqin , Sun Yi 
Published: January 2025

Background:
There is still no conclusive understanding of whether the glucokinase regulator
(GCKR) gene rs780094 and rs1260326 polymorphisms predispose to gestational diabetes
mellitus (GDM).

Objective:
This systematic review and meta-analysis aimed to determine the effect of the GCKR
polymorphisms on GDM susceptibility.

Methods:
Seven literature databases were searched (from inception to February 17, 2024) to locate
relevant studies included in further meta-analysis. Odds ratio (OR) and 95% confidence intervals
(CI) in the pooled population were estimated to assess the effects of the variant allele on
GDM risk.

Results:
For the rs780094 polymorphism, 13 datasets with 3443 GDM cases and 5930 nondiabetic
controls were included. The pooled estimates in the allele model (OR: 1.19, 95% CI:
1.07~1.32), homozygote model (OR: 1.27, 95% CI: 1.10~1.47), dominant model (OR: 1.16, 95%
CI: 1.03~1.31), and recessive model (OR: 1.31, 95% CI: 1.09~1.57) suggested that the C allele carriers
were prone to GDM. For the rs1260326 polymorphism, five datasets with 1495 cases and
2678 controls were integrated. The statistically significant effect of the C allele was evident in the
allele model (OR: 1.12, 95% CI: 1.01~1.24) and the homozygote model (OR: 1.26, 95% CI:
1.03~1.54).

Conclusion:
This meta-analysis suggested that the C allele of the rs780094 and rs1260326 polymorphisms
in the GCKR gene are significantly associated with increased risk of GDM
Cardiovascular Findings and Effects of Caffeine on Experimental
Hypothyroidism
Authors: Yüksel Duygu , Ozmen Ozlem 
Published: January 2025

Background:
Thyroid hormone deficiencies can disrupt organ functions, significantly
impacting the cardiovascular system. Recently, the effects of thyroid hormones on the heart
have garnered increased attention. However, most studies are conducted on humans using clinical
data, while cellular-level and experimental studies remain limited.

Objective:
This study aimed to investigate the cardiovascular implications of hypothyroidism
and evaluate the impact of caffeine on cardiac health in rats induced with hypothyroidism using
propylthiouracil (PTU).

Methods:
The study involved 60 rats divided into six groups. Group 1 served as the untreated
control. Group 2 received PTU for two months to induce hypothyroidism. Group 3 received
PTU for one month, followed by caffeine for one month. Group 4 received caffeine for two
months. Group 5 received both PTU and caffeine simultaneously for two months. Group 6 received
PTU for one month, followed by one month under normal conditions.

Results:
During necropsy, normal thyroid glands were observed in Groups 1, 4, and 6, enlarged
thyroids in Group 2, and smaller thyroids in Groups 3 and 5. Microscopic examination revealed
varying thyroid histologies: Group 2 showed significant epithelial cell proliferation and absent
colloid, while Groups 3, 5, and 6 had altered yet colloid-containing acini. Macroscopic inspection
of hearts appeared normal across all groups. However, histopathological examination revealed
significant hyperemia and microhemorrhages in Group 2, contrasting with normal findings
in other groups. Immunohistochemical analysis indicated reduced cardiac troponin expression
in Group 2, while other groups maintained prominent expression. Additionally, Group 2
displayed increased serum TSH levels and decreased T3 and T4 levels.

Conclusions:
The findings suggest that administering caffeine alongside or after PTU treatment
in rats with experimentally induced hypothyroidism may ameliorate thyroid and cardiac irregularities.
This study indicates caffeine's potential in mitigating the adverse effects of hypothyroidism
on thyroid and heart health.
Lingguizhugan Decoction in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Lu Yifan , Nie Lijuan , Yang Xinyi , Zhao Ziming , Wang Yuxiao , Wu Qibiao , Zhou Xiqiao 
Published: January 2025

Objective:
This study systematically evaluated the efficacy and safety of Ling Gui Zhu
Gan Decoction for treating non-alcoholic fatty liver disease.

Methods:
Registered under CRD42024501460 on the PROSPERO platform, we searched eight
major databases, including Web of Science, PubMed, Cochrane, Embase, China National Knowledge
Infrastructure, Wanfang database, Chinese Scientific Journals Database, and Chinese
Biomedicine Database, from inception to December 2023 for randomized controlled trials on Ling
Gui Zhu Gan Decoction in non-alcoholic fatty liver disease treatment. We extracted data on total
efficiency, TC, TG, ALT, AST, GGT, and HOMA-IR, analyzing results with RevMan 5.4 software.

Results:
Twelve studies met the inclusion criteria, encompassing 970 cases. Ling Gui Zhu Gan Decoction,
alone or combined with standard therapy, significantly improved non-alcoholic fatty liver
disease outcomes, regardless of treatment duration. Only one study reported adverse events, including
bloating, diarrhea, nausea, vomiting, and rash.

Conclusion:
Ling Gui Zhu Gan Decoction appears to be an effective and safe option for non-alcoholic
fatty liver disease treatment. However, due to limited studies and methodological weakness,
further rigorous randomized controlled trials are necessary for conclusive results.
Role of the Nursing Professional in Euthanasia: A Qualitative Systematic Review
Authors: Avila María Isabel Antury , Díaz Chavarro Blanca Cecilia , Campo Alexandra Paja , Vargas Murillo Sandra Milena 
Published: January 2025

Background
Until the date of the search, Euthanasia was legally accepted in 5 countries: the Netherlands, Belgium, Luxembourg, Canada and Colombia.

Objective
We aimed to identify the role of nurses in euthanasia based on articles published both nationally and internationally between 2014 and 2022.

Methods
Qualitative and quantitative studies, editorials, literature reviews and Colombian regulations were included. Publications that did not meet the criteria of the Strengthening the Reporting of Observational Studies in Epidemiology statement and the Spanish Critical Appraisal Skills Programme were excluded. In total, 57 articles were evaluated and 19 were selected. Appropriate copyright principles were followed in accordance with Colombian Law 23 of 1982.

Results
With the data obtained, 4 thematic categories were developed as follows: reception and management of euthanasia requests and regulations in Colombia; emotional accompaniment and effective communication with the patient and family; participation in euthanasia preparations and administration of medications; and management of requests and administration of medications.

Conclusion
Nursing plays an important role in the care of the patient requesting euthanasia, from the reception and management of the request to the administration of the lethal drugs.
Chrysin: A Potential Antiandrogen Ligand to Mutated Androgen Receptors in Prostate Cancer
Authors: Carranza-Aranda Ahtziri Socorro , Santerre Anne , Segura-Cabrera Aldo , Cárdenas-Vargas Albertina , Martínez-Velázquez Moisés , Hernández-Gutiérrez Rodolfo , Herrera-Rodríguez Sara Elisa 
Published: January 2025

Background:
Androgen receptor mutations, particularly T877A and W741L, promote prostate cancer (PCa). The main therapies against PCa use androgen
receptor (AR) antagonists, including Bicalutamide; but these drugs lose their effectiveness over time. Chrysin is a flavonoid with several biological
activities, including antitumoral properties; however, its potential as an antiandrogen must be explored.

Objective:
The present study aimed to characterize and compare the molecular interactions of chrysin with wild-type and mutated ARs and their cytotoxic
effect in an in vitro model of PCa.

Methods:
The affinities and molecular interactions of Bicalutamide and chrysin for the wild-type and mutated forms of AR were assessed by molecular
docking. The MTT assay was used to evaluate the cytotoxic effect of these ligands on the DU-145 (T877A) and PC3 (W741L) PCa cell lines and
on non-tumoral RWPE-1 cells.

Results:
The molecular dockings predicted a higher affinity of chrysin for the mutated AR than the wild-type AR (WT-AR); meanwhile, Bicalutamide
presented a higher affinity for WT-AR. The amino acid residues involved in molecular interactions within the binding site of these receptors
changed according to the ligands and AR variants, affecting their affinity scores. Chrysin exerted a specific cytotoxic effect against the PCa
tumoral cells but none against the non-tumoral cells. In contrast, Bicalutamide showed potent cytotoxicity against all cell lines. Thus, the cytotoxic
effect of chrysin against the DU-145 and PC3 cell line may be related to its strong and specific molecular interaction with the mutated ARs.

Conclusion:
This study evidences the potential antiandrogen effect of chrysin on mutated AR and specific cytotoxicity against PCa cells, suggesting that this
flavonoid should be further studied in vivo to confirm its potential for therapy of advanced PCa.
Sirt1 Regulates Phenotypic Transformation of Diabetic Cardiac Fibroblasts through Akt/Α-SMA Pathway
Authors: Li Xiaomei , Huang Shimeng , Gao Yuanbo , Wang Ying , Zhao Siyu , Lu Bing , Tao Aibin 
Published: January 2025

Aims:
Cardiac fibrosis causes most pathological alterations of cardiomyopathy in diabetes and heart failure patients. The activation and transformation of
cardiac fibroblasts (CFs) are the main pathological mechanisms of cardiac fibrosis. It has been established that Sirtuin1 (Sirt1) plays a protective
role in the pathogenesis of cardiovascular disorders. This study aimed to ascertain the Sirt1 effect on the phenotypic transformation of CFs in
diabetes and its possible mechanisms.

Methods:
Type 1 diabetes was induced in 6-week-old male mice by subcutaneously injecting 50 mg/kg streptozotocin (STZ, i.p.). Western blotting, collagen
staining, and echocardiography were performed to detect protein expression and assess cardiac fibrosis and function in vivo. We used high glucose
(HG) to culture CFs prior to protein expression measurement in vitro.

Results:
Upregulation of Sirt1 expression effectively alleviated the degree of cardiac fibrosis by improving cardiac function in diabetic mice. In vitro
experiments revealed that HG decreased the protein expression levels of Sirt1, but increased those of type I collagen and alpha-smooth muscle
actin (α-SMA), as well as the transdifferentiation of fibroblasts into myofibroblasts. Further studies confirmed that downregulation of Sirt1
expression in the HG environment reduced the protein kinase-B (Akt) phosphorylation, thereby promoting the transdifferentiation of CFs into
myofibroblasts coupled with the deterioration of cardiac function.

Conclusion:
Diabetes mellitus leads to downregulation of Sirt1 protein expression in CFs and decreased Akt phosphorylation, which promotes the
transdifferentiation of CFs into myofibroblasts, the pathological process of cardiac fibrosis, and mediates the incidence and development of
diabetic cardiomyopathy.
Efficiency analysis of the Chilean sawmill industry
Authors: Mejías Caballero Wilson Alexander , Poblete Pamela , Gysling Janina , Ganguly Indroneil , Sepúlveda Oehninger Daniel 
Published: January 2025

Chile plays a significant role in global sawn wood production, ranking 14th in total roundwood and 10th in coniferous sawn wood production in 2022, contributing significantly to the demand for wood products. In the same year, the country exported wood products worth a remarkable $US 6.682 million of, underscoring its importance in the global wood industry. Despite its prominence, the sector has faced significant including mega forest fires and the COVID-19 pandemic, which have adversely affected its performance. One notable issue is the decline in the number of active sawmill units, with only 61 currently producing sawn wood with structural characteristics. The highlights the pressing need to quantify and optimize efficiency within the industry. To address this, Stochastic Frontier Analysis a valuable mathematical framework for evaluating industry efficiency, was employed. Using a dataset compiled by the Chilean Forestry Institute and applying the Stochastic Frontier Analysis methodology, this research assessed the average efficiency of the Chilean sawmill sector. The analysis, based on two different models, consistently revealed a decline in average efficiency during the pandemic. Furthermore, it identified a longitudinal gradient in the efficiency of sawn wood production, with technical inefficiency decreasing towards the southern regions of the country. However, the study did not find direct evidence of a correlation between productivity and the production scale of sawmills. Instead, cost factors, including raw materials, labor, and supplementary expenses, emerged as critical areas requiring careful attention to improve the overall efficiency of the industry.
Del entusiasmo a la desilusión: parcialidades indígenas y soberanía colectiva en la Ciudad de México a través de los escritos de tres intelectuales indígenas, 1812-1827
Authors: Segovia Liga Argelia 
Published: January 2025

La Constitución española de 1812 reconoció a los indígenas americanos como ciudadanos españoles, por lo que algunos letrados nahuas de la Ciudad de México celebraron los logros cívicos de dicha carta y la posibilidad que esto representaba para ser reconocidos como habitantes originales y legítimos dueños de sus propiedades. Sin embargo, durante las primeras décadas del gobierno independiente mexicano, estas esperanzas disminuyeron. El presente ensayo analiza tres breves obras de autoría indígena para conocer su posición con respecto a la creación de la Constitución gaditana, los conflictos en España, el proceso de independencia y los principios liberales, y cómo, a la luz de estos conceptos, interpretaron la ley de repartimiento de las parcialidades indígenas de 1824 en la Ciudad de México.
En el umbral de la “muy cruda guerra”: resistencia indígena en las cartas de la conquista de Chile (1545-1552)
Authors: Salazar Lisboa Eric Francisco 
Published: January 2025

La conquista de Chile no estuvo exenta de dificultades; por el contrario, la resistencia indígena tensionó la dominación desde el arribo de Pedro de Valdivia en 1540. En este sentido, sus cartas revelan la ambivalencia desde la cual se gestó el asentamiento, puesto que narran las adversidades que debieron sortear los peninsulares en el territorio. Con esta premisa, el artículo examina las acciones de resistencia y sus consecuencias en el escenario de la conquista de Chile. La hipótesis plantea que estas secuencias son fundamentales dentro del aparataje retórico e ideológico de Valdivia, pues constituyen un artificio para exaltar sus cualidades y las de sus hombres, en función del enfrentamiento con un enemigo formidable. Solo al final de la exposición, el conquistador encuentra un modo efectivo de desdibujar este pasado complejo, presentando la empresa de un modo exitoso ante el monarca y las demás autoridades.
Ceremonias religiosas y políticas: las visitas y entradas regias de Isabel la Católica en la comedia con referencias indianas Todo es dar en una cosa, de Tirso de Molina
Authors: Zúñiga Lacruz Ana 
Published: January 2025

Las visitas y entradas regias se revisten durante el reinado de los Reyes Católicos de un marcado carácter teatral en el que se entremezclan aspectos políticos y religiosos. Debido a ello y a la importancia de Isabel y Fernando en el devenir histórico de España, los dramaturgos áureos los incorporan a sus obras como modelos de gobernantes y de exaltación de la nación española. En Todo es dar en una cosa, obra de Tirso de Molina dedicada al conquistador Francisco Pizarro, se alude a una visita de los reyes a Guadalupe y a su posterior entrada en Trujillo, lugares de relevancia político-religiosa en el último cuarto del siglo XV. Aparece también sobre las tablas Isabel, en una actuación que concuerda con su imagen mitificada: firme defensora de la fe católica y garante de justicia y paz.
La entrada episcopal en la Puebla de los Ángeles, 1640-1774
Authors: Rosas Salas Sergio 
Published: January 2025

El objetivo de este artículo es estudiar la entrada episcopal en Puebla de los Ángeles entre 1640 y 1774, a fin de contribuir al estudio de las fiestas relacionadas con el obispo en Nueva España y en las Indias. Por medio de la consulta de los archivos históricos de los cabildos eclesiástico y secular de aquella ciudad, se argumenta que durante los siglos XVII y XVIII la entrada episcopal en Puebla hizo evidente la importancia de la urbe como ámbito cristiano por excelencia y, en consecuencia, funcionó como un ritual público que exaltó la figura del obispo como la cabeza de la civitas cristiana, al mismo tiempo que representó a la ciudad como un dominio privilegiado de la cristiandad en el Nuevo Mundo.
Festejos por la Tregua de Niza en la Nueva España: La conquista de Rodas y La conquista de Jerusalén (1539)
Authors: Aracil Varón Beatriz 
Published: January 2025

La Tregua de Niza, firmada entre Carlos V y el rey de Francia en mayo de 1538, fue celebrada en Nueva España meses más tarde con fastos que incluyeron representaciones de “moros y cristianos”, entre las que destacan La conquista de Rodas (en la ciudad de México) y La conquista de Jerusalén (en Tlaxcala). La elección de los temas de ambas obras (justificada por el contexto de nueva cruzada contra el turco) y el desarrollo de sus puestas en escena fueron una demostración de poder y de fidelidad al imperio por parte de las élites novohispanas. Pero tanto esas obras como los festejos que las albergaron reflejaron asimismo los conflictos surgidos entre las dos máximas figuras del virreinato: el conquistador Hernán Cortés y el representante del poder real, Antonio de Mendoza.
Impact of self-evaluation strategy on mathematical achievement: An empirical study among undergraduate mathematics education students
Authors: Oguguo Basil Chinecherem , Ugorji Clifford O. , Ohwoavworhua Loveth 
Published: January 2025

Background: Given Nigerian students’ poor achievement in mathematics performance over the years, researchers are exploring how a self-evaluation learning strategy can improve this situation. This strategy empowers students to assess their own understanding of learning materials in the subject, apply concepts effectively, and accurately complete tasks.Aim: The author examined the impact of self-evaluation strategy on mathematical achievement among undergraduate mathematics education students in Nigeria.Method: The researcher adopted Correlational survey research design. Participants (N = 357) were 3rd year undergraduate mathematics students at a public University in Nigeria. Data was collected using two researcher-developed instruments: Students’ Self-evaluation Learning Strategy Questionnaire (SSLSQ) and Students Mathematics Academic Achievement Proforma (SMAAP). The internal consistency reliability index obtained using Cronbach Alpha was 0.77. Data collected were analyzed using simple linear regression analyses through SPSS version 26.0 as well as regression analysis through Process model 1 procedure IBM SPSS version 4.00.Result: Findings from the study revealed that self-evaluation learning strategy positively impacted students' achievement in Mathematics. Specifically, 22% of the variation in students’ achievement in Mathematics is attributed to self-evaluation learning. The stdy also revealed a significant difference in the mean achievement score of mathematics students taught in public universities who used self-evaluation compared to those who did not.Conclusion: Students should be encouraged by Mathematics teachers to adopt Self-evaluation strategy when assessing their learning outcomes to enhance their learning of the subject.
Analisis Pengaruh Kepemilikan Asing, Kinerja Lingkungan Dan Ukuran Perusahaan Terhadap Pengungkapan Corporate Social Responsibility
Authors: Hanifah Apriliyah Nur , Umaimah Umaimah 
Published: January 2025

Many companies ignore their social responsibility, but companies forget that social responsibility is an important attribute to improve a company's good reputation. Currently companies are developing capital and improving the environment, companies are paying more attention to the surrounding environment because the environment around the company can influence the company. This research was conducted with the aim of measuring the influence of foreign ownership, environmental performance and company size on Corporate Social Responsibility disclosure. This research selects manufacturing companies listed on the Indonesia Stock Exchange (BEI) in the 2023 period. The sample in this research consists of 40 samples taken using the purposive sampling method used in this research is multiple linear regression analysis using SPSS. The research results show that foreign ownership does not have a significant effect on the scope of Corporate Social Responsibility, company size also does not have a significant effect on the scope of Corporate Social Responsibility, but environmental performance has a significant effect on the scope Corporate Social Responsibility.
Unraveling the Impact of Collaborative Competency on Collaborative Governance in Public Sector Organizations
Authors: Djalil Muslim A. , Chan Syafruddin , Putra Teuku Roli Ilhamsyah , Tabrani Mirza , Agustina Maulidar 
Published: January 2025

Objective: The study investigates the influence of collaborative competency on collaborative governance, with innovative governance serving as a mediator, in the provincial government agencies of Aceh Province, Indonesia.

Theoretical Framework: the application of innovative governance to mediate the influence of collaborative competency on collaborative governance in the public sector.

Method: The research utilizes the Amos software as a data processing instrument to employ the Structural Equation Modeling (SEM) quantitative model. The investigation was conducted with 242 government officials from 54 Provincial Government Working Agencies (SKPA) in the province, representing top, middle, and operational management. Data of respondents were collected by disseminating closed-ended questionnaires in the form of Google forms via email and the provincial agency's WhatsApp group.

Results and Discussions: The findings indicate that collaborative competency has significant direct effects on both innovative and collaborative governance, as well as a direct effect of innovative governance on collaborative governance. Additionally, the relationship between collaborative governance and collaborative competency is mediated by innovative governance.

Research Implications: This research suggests that the quality and efficiency of public service delivery can be improved by enhancing collaborative competencies within government agencies, which can result in more effective and innovative governance practices. This emphasizes the necessity of creating policies and training programs that encourage the development of innovative approaches and collaborative skills among government officials.

Originality/Value: In contrast to prior literature, which has primarily examined human resource competencies, effective governance, collaborative governance, employee productivity, and organizational performance. Nevertheless, the comprehensive investigation of the role of innovative governance in mediating the relationship between collaborative competencies and collaborative governance, particularly in the provincial government context, has not yet been completed.