bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study
Authors: Zarghami Tahereh S. , Zeidman Peter , Razi Adeel , Bahrami Fariba , Hossein‐Zadeh Gholam‐Ali 
Published: March 2023

AbstractSchizophrenia (SZ) is a severe mental disorder characterized by failure of functional integration (aka dysconnection) across the brain. Recent functional connectivity (FC) studies have adopted functional parcellations to define subnetworks of large‐scale networks, and to characterize the (dys)connection between them, in normal and clinical populations. While FC examines statistical dependencies between observations, model‐based effective connectivity (EC) can disclose the causal influences that underwrite the observed dependencies. In this study, we investigated resting state EC within seven large‐scale networks, in 66 SZ and 74 healthy subjects from a public dataset. The results showed that a remarkable 33% of the effective connections (among subnetworks) of the cognitive control network had been pathologically modulated in SZ. Further dysconnection was identified within the visual, default mode and sensorimotor networks of SZ subjects, with 24%, 20%, and 11% aberrant couplings. Overall, the proportion of discriminative connections was remarkably larger in EC (24%) than FC (1%) analysis. Subsequently, to study the neural correlates of impaired cognition in SZ, we conducted a canonical correlation analysis between the EC parameters and the cognitive scores of the patients. As such, the self‐inhibitions of supplementary motor area and paracentral lobule (in the sensorimotor network) and the excitatory connection from parahippocampal gyrus to inferior temporal gyrus (in the cognitive control network) were significantly correlated with the social cognition, reasoning/problem solving and working memory capabilities of the patients. Future research can investigate the potential of whole‐brain EC as a biomarker for diagnosis of brain disorders and for neuroimaging‐based cognitive assessment.
Right hemispheric structural connectivity and poststroke language recovery
Authors: Sihvonen Aleksi J. , Vadinova Veronika , Garden Kimberley L. , Meinzer Marcus , Roxbury Tracy , O'Brien Kate , Copland David , McMahon Katie L. , Brownsett Sonia L. E. 
Published: March 2023

AbstractPoststroke aphasia typically results from brain damage to the left‐lateralized language network. The contribution of the right‐lateralized homologues in aphasia recovery remains equivocal. In this longitudinal observational study, we specifically investigated the role of right hemisphere structural connectome in aphasia recovery. Twenty‐two patients with aphasia after a left hemispheric stroke underwent comprehensive language assessment at the early subacute and chronic stages. A novel structural connectometry approach, using multi‐shell diffusion‐weighted MRI data collected at the early subacute stage, was used to evaluate the relationship between right hemisphere white matter connectome and language production and comprehension abilities at early subacute stage. Moreover, we evaluated the relationship between early subacute right hemisphere white matter connectome and longitudinal change in language production and comprehension abilities. All results were corrected for multiple comparisons. Connectometry analyses revealed negative associations between early subacute stage right hemisphere structural connectivity and language production, both cross‐sectionally and longitudinally (pFDR < .0125). In turn, only positive associations between right hemisphere structural connectivity and language comprehension were observed, both cross‐sectionally and longitudinally (pFDR < .0125). Interhemispheric connectivity was highly associated with comprehension scores. Our results shed light on the discordant interpretations of previous findings, by providing evidence that while some right hemisphere white matter pathways may make a maladaptive contribution to the recovery of language, other pathways support the recovery of language, especially comprehension abilities.
Neural bases of the bodily self as revealed by electrical brain stimulation: A systematic review
Authors: Dary Zoé , Lenggenhager Bigna , Lagarde Stanislas , Medina Villalon Samuel , Bartolomei Fabrice , Lopez Christophe 
Published: March 2023

AbstractAn increasing amount of recent research has focused on the multisensory and neural bases of the bodily self. This pre‐reflective form of self is considered as multifaceted, incorporating phenomenal components, such as self location, body ownership, first‐person perspective, agency, and the perceptual body image. Direct electrical brain stimulation (EBS) during presurgical evaluation of epilepsy and brain tumor resection is a unique method to causally relate specific brain areas to the various phenomenal components of the bodily self. We conducted a systematic review of the literature describing altered phenomenal experience of the bodily self evoked by EBS. We included 42 articles and analyzed self reports from 221 patients. Three‐dimensional density maps of EBS revealed that stimulation in the middle cingulum, inferior parietal lobule, supplementary motor area, posterior insula, hippocampal complex/amygdala, and precuneus most consistently altered one or several components of the bodily self. In addition, we found that only EBS in the parietal cortex induced disturbances of all five components of the bodily self considered in this review article. These findings inform current neuroscientific models of the bodily self.
A “bottom up” Health in All Policies program: Supporting local government wellbeing approaches
Authors: Lauzon Chantal , Stevenson Anna , Peel Kirsty , Brinsdon Sandy 
Published: March 2023

AbstractIssue AddressedA wellbeing economy requires multiple inputs to enable the wholistic vision of a sustainable healthy population and planet. A Health in All Policies (HiAP) approach is a useful way to support policy makers and planners to implement the activities required to support a wellbeing economy.Outline of the ProjectAotearoa New Zealand's Government has explicitly set a path towards a wellbeing economy. Here, we report the utility of a HiAP approach in Greater Christchurch, the largest urban area in the South Island of New Zealand, to achieving the shared societal goals of a sustainable healthy population and environment. We use the World Health Organisation draft Four Pillars for HiAP implementation as a framework for discussion.So What?The paper adds to the growing number of examples of city and regions supporting a wellbeing agenda, specifically focused on some of the successes and challenges for local HiAP practitioners working within a public health unit in influencing this work.
Evaluating an online module for sexual violence prevention in a tertiary educational setting: An exploratory study
Authors: Heard Emma , Evans Cezara , Buckley Lisa , Hatchman Kate , Masser Barbara 
Published: March 2023

AbstractIssue AddressedSexual violence is an important public health issue affecting significant numbers of university students across Australia and internationally. In response, online modules have been widely implemented and there is an urgent need to better understand their effectiveness. The aim of this study was to evaluate an online sexual violence prevention and response education module designed for and implemented in one Australian university.MethodsWe used a mixed‐methods approach that included pre/post module completion surveys of key measures relating to sexual consent, being a bystander, and response to disclosures as well as knowledge of resources and support services. We conducted post module completion semi‐structured interviews.ResultsResults indicated potential effectiveness of the module on beliefs about sexual consent, confidence intervening when witnessing potentially harmful situations, willingness to report incidents, confidence supporting a peer who discloses an incident, and knowledge of support services. Qualitative results indicated support for the online module as an accessible, private and self‐paced tool for sexual violence education. Interactive, relevant and engaging content that can be applied in real‐life contexts was noted as key for effectiveness.ConclusionsThis exploratory study suggests there may be potential for online modules to be effective, as one aspect of universities' sexual violence prevention and response strategies—particularly modules aimed at addressing primary, secondary and tertiary prevention. Further rigorous research is required to strengthen best practice in the development and implementation of online modules as part of whole‐of‐campus strategies.So What?Universities across Australia and internationally are grappling with sexual violence response and prevention in light of high prevalence rates among students. Online modules may be one effective tool when implemented as part of a wider strategy.
How do hydrologists perceive watersheds? A survey and analysis of perceptual model figures for experimental watersheds
Authors: McMillan Hilary , Araki Ryoko , Gnann Sebastian , Woods Ross , Wagener Thorsten 
Published: March 2023

AbstractTo describe process knowledge at the watershed scale, hydrologists commonly refer to a ‘perceptual model’, an expert summary of the watershed and its runoff processes often supported by field observations. Perceptual models are often presented as a schematic figure, although such a figure will necessarily simplify the hydrologist's complex mental model. In this paper, our aim was to understand what constitutes a visual expert summary of watershed process knowledge, and to evaluate how perceptual models could be used to share hydrological process information at larger scales. To do so, we conducted a systematic review of the literature and found 63 perceptual model figures. We counted and categorized the stores and fluxes in each figure using a taxonomic classification and quantified a variety of figure attributes including spatial or temporal zonation, inclusion of vegetation, soils, topographical and geological data and consideration of uncertainty. Our analysis showed that a typical figure has 1 surface flux, 4 subsurface fluxes, 3–4 subsurface stores and 0–1 channel stores; 28 out of 63 figures use sub‐figures to show temporal dynamics (e.g., wet/dry conditions), and 12 out of 63 show spatial zones. Perceptual model figures, therefore, provide a concise summary of watershed processes with a complexity comparable to that of many conceptual hydrological models. However, only four figures showed any information on uncertainty or knowledge gaps. We recommend that perceptual figure value could be easily increased by consistent captioning of figures to assist automated search, and wider use of standard figure annotations such as legends and scale markings to ensure that information is fully conveyed to the user. If perceptual figures are proposed as a primary method for sharing process information, the hydrological community should consider how to link more detailed text descriptions to figures, and how to represent process uncertainty.
Resistance of river ice covers to mobilization and implications for breakup progression in Peace River, Canada
Authors: Beltaos Spyros 
Published: March 2023

AbstractPrediction and modelling of ice breakup initiation and progress over extended river reaches is largely unattainable at present, despite the ecological and socio‐economic significance of the breakup event and associated ice jams that form in many rivers of Asia, Europe and North America. A key question is how to quantify the driving and resisting forces that are applied on the winter ice cover, which control the timing of its dislodgment, mobilization and subsequent jamming locations. Using a physics‐based onset criterion, explicit expressions for these forces are formulated. The more complex of the two is the resistance, which comprises components related to ice strength and thickness, channel curvature, thermal degradation of the ice cover during the pre‐breakup period, and freezeup level (defined as peak 7‐day running average water level during late fall and early winter). This insight is then used in a case study of recent dynamic breakups in a major Canadian river, explaining apparently random differences in the rate of advance of the breakup front among three different years. It is shown further that contradictory results are obtained when the effect of the freezeup level is ignored.
Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases
Authors: Yan Shan‐Shan , Campos de Souza Senio , Xie Zhen‐Dong , Bao Yong‐Xin 
Published: March 2023

AbstractThe incidence of stroke and neurodegenerative diseases is gradually increasing in modern society, but there is still no treatment that is effective enough. Stem cells are cells that can reproduce (self‐renew) and differentiate into the body, which have shown significance in basic research, while doctors have also taken them into clinical trials to determine their efficacy and safety. Existing clinical trials mainly include middle‐aged and elderly patients with stroke or Parkinson's disease (mostly 40–80 years old), mainly involving injection of mesenchymal stem cells and bone marrow mesenchymal stem cells through the veins and the putamen, with a dosage of mostly 106–108 cells. The neural and motor functions of the patients were restored after stem cell therapy, and the safety was found to be good during the follow‐up period of 3 months to 5 years. Here, we review all clinical trials and the latest advances in stroke, Alzheimer's disease, and Parkinson's disease, with the hope that stem cell therapy will be used in the clinic in the future to achieve effective treatment rates and benefit patients.
Chemoproteomic Approaches for Unraveling Prokaryotic Biology
Authors: Malarney Kien P. , Chang Pamela V. 
Published: March 2023

AbstractBacteria are ubiquitous lifeforms with important roles in the environment, biotechnology, and human health. Many of the functions that bacteria perform are mediated by proteins and enzymes, which catalyze metabolic transformations of small molecules and modifications of proteins. To better understand these biological processes, chemical proteomic approaches, including activity‐based protein profiling, have been developed to interrogate protein function and enzymatic activity in physiologically relevant contexts. Here, chemoproteomic strategies and technological advances for studying bacterial physiology, pathogenesis, and metabolism are discussed. The development of chemoproteomic approaches for characterizing protein function and enzymatic activity within bacteria remains an active area of research, and continued innovations are expected to provide breakthroughs in understanding bacterial biology.
How to Break the Law: trans‐Hydroboration and gem‐Hydroboration of Alkynes
Authors: Fürstner Alois 
Published: March 2023

AbstractClassical hydroboration is the textbook example of an organometallic reaction under rigorous frontier orbital control: a synergetic bonding mode between substrate and reagent evolves into a four‐membered transition state that enforces syn/suprafacial delivery of H−BR2 to the π‐system. This strict stereochemical “law” remained valid for decades, even after the advent of metal‐catalyzed hydroboration. During the last decade, however, numerous possibilities emerged that allow this paradigm to be challenged. Thus, direct trans‐hydroboration of terminal as well as internal alkynes was achieved through radical, ionic, organocatalytic, and metal‐catalyzed manifolds, which are summarized in this review. Among them, pathways involving either metal vinylidenes (Rh, Ir, Ru, Fe) derived from terminal alkynes or metallacyclopropenes (η2‐vinylmetal complexes) derived from an internal triple bond and a [CpXRu]‐based catalyst represent the currently most widely applicable solutions. The latter type of intermediates is also accountable for the equally perplexing gem‐hydroboration of alkynes: geminal delivery of a borane to a triple bond has no precedent in the classical canon. The only forerunner was gem‐hydrogenation, which represents an unconventional yet highly useful entry into discrete ruthenium carbene complexes. The close mechanistic ties between these transformations are outlined, and brief reference is also made to remotely related reactions such as trans‐diboration and trans‐carboboration.
Associations between trajectories of adolescent conduct problems and psychological well‐being in young women
Authors: O'Brien Christopher T. , Bell Melissa , Hipwell Alison E. , Stepp Stephanie D. 
Published: March 2023

AbstractIntroductionDespite the clinical relevance, little is known about variability in positive adult outcomes (i.e., flourishing, life satisfaction) of female adolescent conduct problems (CP), or interpersonal factors that promote these types of well‐being. We hypothesized differential associations between adolescent CP trajectories and indicators of adult well‐being due to level of positive relationships with caregivers during ages 12−17.MethodData were drawn from participants (N = 1965) of the Pittsburgh Girls Study, a longitudinal study of girls' development. Caregiver reported CP, adolescent reports of parental trust and positive parenting, and adolescent‐reported peer delinquency were assessed annually between ages 12−17. Well‐being in young adulthood was measured using self‐reported flourishing and life satisfaction between ages 18−22.ResultsLatent class growth analysis of adolescent CP revealed four trajectories characterized as low stable (20.0%), moderate stable (63.9%), adolescent‐onset (8.1%), and high quadratic (8.0%). Main effects of trust and positive relationships with caregivers during adolescence on well‐being in early adulthood were found. Positive parenting was found to moderate the association between CP trajectory and flourishing. The magnitude of the negative association between the high quadratic trajectory group and life satisfaction decreased as positive parenting increased.ConclusionThese results support the importance of intervention in adolescence to focus on increasing trusting and positive relationships with caregivers for all females, as this may increase well‐being in adulthood regardless of adolescent CP history.
Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus
Authors: Haffner-Luntzer Melanie , Ragipoglu Deniz , Ahmad Mubashir , Schoppa Astrid , Steppe Lena , Fischer Verena , Luther Julia , Yorgan Timur , Bockamp Ernesto , Amling Michael , Schinke Thorsten , Ignatius Anita 
Published: March 2023

Abstract
Despite considerable improvement in fracture care, 5%–10% of all fractures still heal poorly or result in nonunion formation. Therefore, there is an urgent need to identify new molecules that can be used to improve bone fracture healing. One activator of the Wnt-signaling cascade, Wnt1, has recently gained attention for its intense osteoanabolic effect on the intact skeleton. The aim of the present study was to investigate whether Wnt1 might be a promising molecule to accelerate fracture healing both in skeletally healthy and osteoporotic mice that display a diminished healing capacity. Transgenic mice for a temporary induction of Wnt1 specifically in osteoblasts (Wnt1-tg) were subjected to femur osteotomy. Non-ovariectomized and ovariectomized Wnt1-tg mice displayed significantly accelerated fracture healing based on a strong increase in bone formation in the fracture callus. Transcriptome profiling revealed that Hippo/yes1-associated transcriptional regulator (YAP)-signaling and bone morphogenetic protein (BMP) signaling pathways were highly enriched in the fracture callus of Wnt1-tg animals. Immunohistochemical staining confirmed increased activation of YAP1 and expression of BMP2 in osteoblasts in the fracture callus. Therefore, our data indicate that Wnt1 boosts bone formation during fracture healing via YAP/BMP signaling both under healthy and osteoporotic conditions. To further test a potential translational application of Wnt1, we applied recombinant Wnt1 embedded into a collagen gel during critical-size bone-defect repair. Mice treated with Wnt1 displayed increased bone regeneration compared to control mice accompanied by increased YAP1/BMP2 expression in the defect area. These findings are of high clinical relevance because they indicate that Wnt1 could be used as a new therapeutic agent to treat orthopedic complications in the clinic. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
The effect of accounting for high performing employee services as a right of use asset on the balance sheet on nonprofessional investors judgments
Authors: Ampofo Akwasi , Barkhi Reza , Nketia Joseph 
Published: March 2023

AbstractWe examine whether accounting for high performing employee services as a right of use (ROU) asset and related liability on the balance sheet provide decision‐useful financial statement information to nonprofessional investors (NPIs). We compare accounting for the right to use employees services as an asset on‐balance‐sheet (ONBS) and off‐balance‐sheet (OFFBS) to examine the extent to which a ROU asset and related liability provides NPIs with decision‐useful information in assessing investment opportunity and likelihood to invest in a company's stock. We analyze one hundred and fifty‐five usable responses of which 84 are in OFFBS control condition and 71 are in ONBS treatment condition. We find that accounting for high performing employees services as a ROU asset ONBS or OFFBS provides decision‐useful information to NPIs that is not statistically different. Further analysis indicates that accounting for high performing employees as a ROU intangible asset presented ONBS, measured at fair value, or amortized cost with enhanced disaggregation and roll forward disclosures provide decision‐useful information to NPIs. The likelihood to invest in a company's stock significantly increases if the ROU asset is measured at fair value with changes recorded in net income. Results have economic and practical implications for investors, standard‐setters, and researchers.
Obesity‐mediated upregulation of the YAP/IL33 signaling axis promotes aggressiveness and induces an immunosuppressive tumor microenvironment in breast cancer
Authors: Dai Jia‐Zih , Yang Ching‐Chieh , Shueng Pei‐Wei , Wang Yen‐Ju , Huang Chen‐Shiuan , Chao Yi‐Chun , Chen Cheng‐Hsun , Lin Cheng‐Wei 
Published: March 2023

AbstractObesity is a well‐known risk factor for breast cancer formation and is associated with elevated mortality and a poor prognosis. An obesity‐mediated inflammatory microenvironment is conducive to the malignant progression of tumors. However, the detailed molecular mechanism is still needed to be clarified. Herein, we identified that breast cancer cells from mice with diet‐induced obesity exhibited increased growth, invasiveness, and stemness capacities. A transcriptome analysis revealed that expressions of interleukin 33 (IL33) signaling pathway‐related genes were elevated in obesity‐associated breast cancer cells. Importantly, IL33 expression was significantly associated with the yes‐associated protein (YAP) signature, and IL33 was transcriptionally regulated by YAP. Suppression of IL33 reduced tumor migration and invasion, while the addition of IL33 activated nuclear factor (NF)‐κB signaling and revived tumor mobility in YAP‐silenced cells. Furthermore, suppression of YAP attenuated IL33 expression which was accompanied by relief of obesity‐mediated immunosuppression. Clinical analyses showed that IL33 expression was markedly associated with macrophage and regulatory T cell infiltration. These findings reveal a crucial role of the YAP/IL33 axis in promoting aggressiveness and immunosuppression of obesity‐associated breast cancer progression.