bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kualitas Website E-Non PNS di Kecamatan Waru Menggunakan Metode Webqual 4.0
Authors: Mawadah Latifatul , Setyaningsih Erlin 
Published: May 2023

Penelitian ini berjudul Pengaruh kualitas website E-NON PNS di kecamatan waru. Fokus masalah yang diteliti dalam skripsi ini ialah bagaimana pengguna website E-NON PNS pada pegawai dan guru honorer yang berada diwilayah kecamatan waru dengan jumlah sampel sebanyak 104 responden pengguna website E-NON PNS. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruhi kualitas website dengan metode webqual 4. 0. Metode pengumpulan data menggunakan kuesioner yang telah di uji ke 104 responden dan dilakukan uji validitas, uji reliabilitas yang menghasilkan 100% pernyataan dikatakan valid dan layak untuk digunakan. Pengujian pada penelitian ini menggunakan uji asumsi klasik ( Uji normalitas, Uji multikolinearitas, Uji Heteroskedastisitas dan Uji linearitas), Uji Regresi Linier (Uji T dan Uji F) dengan bantuan software SPSS versi 26. Dari hasil pengujian asumsi pada uji normalitas diperoleh hasil 0,200 >0,05, Uji multikolinearitas pada variabel Usability Quality nilai tolerance 0,502 >0,01 dan VIF 1. 993 < 10 Information Quality nilai tolerance 0,348>0,05 dan VIF 2. 872 < 10 Interaction Quality nilai tolerance 0,399 > 0,05 dan VIF 2. 509 < 10. Uji T bisa di lihat jika r hitung> r tabel pada variabel Usability Quality (6. 573 > 1. 987) dan nilai signifikansinya lebih kecil dari pada Alpha (0,000<0,05) Information Quality (0. 002< 1. 987) dan nilai signifikansinya (0,984>0,05) Interaction Quality (3. 470> 1. 987) dan nilai signifikansinya (0,01< 0,05) dari pengujian ini bisa di lihat bahwa Information Quality tidak berpengaruh positif terhadap User Satisfaction. Metode yang digunakan dalam penelitian ini adalah penelitian asosiatif
Using an Intervention Mapping Approach to Improve Adherence to Disease-Modifying Treatment in Multiple Sclerosis
Authors: Neter Efrat , Miller Ariel 
Published: May 2023

ABSTRACT

BACKGROUND
Up to 50% of individuals with multiple sclerosis (MS) who are prescribed disease-modifying treatments (DMTs) do not take them as advised. Although many studies report on DMT adherence rate, few studies report on interventions involving individuals with MS. The current paper describes the development of an intervention aimed at improving adherence to DMTs among identified nonadherent individuals with MS.

METHODS
An intervention was developed using an Intervention Mapping approach, recommendations from reviews on medication adherence, and input from individuals with MS. Its content was determined by theories of health behavior (specifically, a perceptions and practicalities approach), empirical evidence collected among the specific target population (an observational “needs assessment” stage [n = 186]), and other studies.

RESULTS
A personalized intervention was tailored to the reasons for nonadherence, uncovered during the observational needs assessment stage, to be delivered sequentially by a neurologist and a psychologist. After the intervention objectives were identified, components of the intervention were set: psychoeducation and ways of coping with adverse effects; modification of unhelpful treatment beliefs (such modifications were found predictive of adherence in the observational phase of the study); improving confidence and self-efficacy; and developing strategies for remembering to take DMTs. These components were embedded within motivational interviewing.

CONCLUSIONS
Intervention Mapping was useful in developing an intervention grounded both in the theoretical approach of perceptions and practicalities and in empirical evidence from the literature and the target sample; concurrently, identifying determinants that the intervention did not address. The effectiveness of the intervention—which could potentially improve adherence among individuals with MS—needs to be examined.
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Authors: Granell Raquel , Curtin John A , Haider Sadia , Kitaba Negusse Tadesse , Mathie Sara A , Gregory Lisa G , Yates Laura L , Tutino Mauro , Hankinson Jenny , Perretti Mauro , Vonk Judith M , Arshad Hasan S , Cullinan Paul , Fontanella Sara , Roberts Graham C , Koppelman Gerard H , Simpson Angela , Turner Steve W , Murray Clare S , Lloyd Clare M , Holloway John W , Custovic Adnan ,   on behalf of UNICORN and Breathing Together investigators
Published: May 2023

Background:Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes.Methods:We conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9568 individuals from five UK birth cohorts.Results:Forty-four independent SNPs were associated with early-onset persistent, 25 with pre-school remitting, 33 with mid-childhood remitting, and 32 with late-onset wheeze. We identified a novel locus on chr9q21.13 (close to annexin 1 [ANXA1], p<6.7 × 10-9), associated exclusively with early-onset persistent wheeze. We identified rs75260654 as the most likely causative single nucleotide polymorphism (SNP) using Promoter Capture Hi-C loops, and then showed that the risk allele (T) confers a reduction in ANXA1 expression. Finally, in a murine model of house dust mite (HDM)-induced allergic airway disease, we demonstrated that anxa1 protein expression increased and anxa1 mRNA was significantly induced in lung tissue following HDM exposure. Using anxa1-/- deficient mice, we showed that loss of anxa1 results in heightened airway hyperreactivity and Th2 inflammation upon allergen challenge.Conclusions:Targeting this pathway in persistent disease may represent an exciting therapeutic prospect.Funding:UK Medical Research Council Programme Grant MR/S025340/1 and the Wellcome Trust Strategic Award (108818/15/Z) provided most of the funding for this study.
Review of Episodic Voyage of Engineering Surveying and Cartography in India
Authors: Nanda Rabindranath , Mishra Siba Prasad , Barik Kamal Kumar , Sethi Kumar Ch. 
Published: May 2023

This study presents the Episodic Voyage of Engineering Surveying and Cartography in India to know our past development in mapmaking and cartography, which is as old as Ptolemy’s expedition in the 2nd century AD in India. Starting from ropes and sticks to measure, plumb bobs to position, site rule for sighting, and clinometer for height measurement, the Indians and people from other countries, developed the present instruments and methodologies. They have evolved by gathering big data and up to making smart maps by today. The methodology employed is to collect data about the development of innovative technologies in the last 15th to 21st centuries. The journey commenced from Zareb, Kadi, etc. to the development of geo-informatics with the practices of Aerial photography, Geographical Information Systems (GIS), Remote Sensing (RS), Global Positioning Systems (GPS), Image Processing, Photogrammetry by unmanned aerial vehicle (UAV), Light Detecting and Ranging (LiDAR), Web GIS, through large-scale map generation. The innovative practices have given a new direction to the subjects like geography, geology, urban planning, landscaping, and other human application services. The present study includes the search for the advances in surveying and map-making journey to date and the way forward. Eventually, the evolution of technologies will influence greatly the surveying and map-generating Present process. The application handling in the current geospatial ecosystem can be complied with by compiling large-scale maps 1:500, 1:1000, etc. through automation for better smart city planning in India. The change shall paddle the economic growth in different developing countries. However, the survey of marine territories of India is poorly researched.
Satisfaction and Knowledge of Emergency Residents about Journal Club
Authors: Alotaibi Majed Alawe , Alanazi Mazi Mohammed , Alanazi Fadiyah Dhami , Homoddah Ahmad Mohammad , Alsaedi Hashim Marshud R. , Alharbi Fahad Hadram Al Asemr , Alamri Rayan Dhaif Allah A. 
Published: May 2023

Background: The key teaching-learning activity journal club provides a platform for developing critical evaluation skills. It makes it easier to stay current with new research, enabling residents to improve patient care, and assisting them in developing into knowledgeable specialists.
Methods: A cross-sectional survey was conducted in March 2023 among emergency department residents at King Saud Medical City (KSMC), King Salman Hospital, Aliman General Hospital, and Imam Abdulrahman Alfaisal Hospital. This study was conducted to find out how individuals felt about having journal club as part of the curriculum. 124 emergency registrars participated in a survey. The goal of the study was explained, and instructions for filling out the survey forms were given. In order to analyze the data, SPSS version 24 was used. The study variables were represented by descriptive statistics (the frequency with percentages for categorical variables), and the chi-square test was employed to determine statistical significance.
Results: A total of 124 (N = 124) emergency residents responded to the survey. 45 (36.2%) residents from R1 and 33 (26.6%) from R2. 71% of participants were male and 29% were female. Journal clubs are not well known to the majority of R1 locals (48.7%). However, a significant portion of R4 residents (29.27%) are familiar with journal clubs. The majority of residents (39%), first learned about journal club from friends, followed by the internet (35%), journal club attendance (9%), and literature (16% of residents), in that order. The main justification offered for not incorporating a journal club into the curriculum is that it takes a lot of time to prepare.
Conclusion: A journal club would increase residents’ capacity for lifelong learning. It is a useful educational tool to help them comprehend the processes involved in conducting research that would enhance patient care.
Kielin/chordin‐like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein‐2
Authors: Nagasaki Kei , Yamada Atsushi , Sasa Kiyohito , Kamijo Ryutaro 
Published: May 2023

Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin‐like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression, and calcification data demonstrating that Kcp affects the differentiation of C2C12 myoblasts into osteoblasts. We report that the presence of Kcp enhances the ability of BMP‐2 to induce the differentiation of C2C12 myoblasts into osteoblasts. Additionally, BMP‐2‐mediated stimulation of phosphorylated Smad1/5 was apparently enhanced in the presence of Kcp. The present findings may contribute to progression toward the clinical use of BMPs for treatment of bone fracture, osteoarthritis, and other similar conditions.
Functional Regression Control Charts with an Application to Ship Fuel Consumption Monitoring
Authors: Capezza Christian , Centofanti Fabio , Lepore Antonio , Menafoglio Alessandra , Palumbo Biagio , Vantini Simone 
Published: May 2023

AbstractIn many industrial scenarios, the process quality characteristic of interest can be either a scalar or, in a more general case, a profile, that is, a function defined on a compact set, usually time or space. In the latter case, the quality characteristic can also be referred to asfunctionalquality characteristic. Profiles are usually obtained from measurements of the quality characteristic collected at discrete time or space points. The set of statistical process control techniques developed for this type of data is calledprofile monitoring. Often, thanks to the new data acquisition technologies, together with the quality characteristic of interest, other covariates associated with it are available as well. For example, this applies to the maritime transportation, where shipping companies are urged by worldwide and European regulations to monitor CO2emissions of their fleet, when many other additional factors, which affect CO2emissions, are also jointly measured. Motivated by this context, this article illustrates the use of the functional regression control chart framework to enhance the monitoring of either a scalar or a functional quality characteristic using the information on covariates related to it, which can be in the form of scalars or profiles as well.
Fourier Expansion
Authors: Parkinson Christian 
Published: May 2023

AbstractWe provide a basic overview of Fourier expansion: a method for representing a function as an infinite sum of sine waves with different amplitudes and frequencies. We develop the Fourier expansion of a function using either real or complex Fourier modes and discuss some issues of convergence and approximation by truncated Fourier series. We briefly mention the theoretical connection with the continuous Fourier transform and discuss generalizations to other types of orthogonal function expansion. Lastly, we point out some applications of Fourier expansion in statistics and other disciplines.
Process Analysis with Data Segments
Authors: Kenett Ron S. 
Published: May 2023

Abstract
Control charts are applied in running a process under statistical control. Process capability analysis is conducted retrospectively on data to characterize a process under control and set up the control limits of a control chart. In this article, we expand on the process capability analysis by considering time‐related patterns. Specifically, we focus on data segments that can show up in the data collected during process capability analysis. If such segments are detected, and investigations reveal the causes for such segments, the analyst might decide to focus on a data segment representing a steady‐state stable process, as opposed to the full data collected for process capability analysis. In this context, one will aim at identifying transient periods and not include them in the computation of control limits. We provide here two methods for identifying such segments. One method is based on decision trees. The second method is applying functional data analysis.
2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis
Authors: England Bryant R. , Smith Benjamin J. , Baker Nancy A. , Barton Jennifer L. , Oatis Carol A. , Guyatt Gordon , Anandarajah Allen , Carandang Kristine , Chan Karmela Kim , Constien Deb , Davidson Eileen , Dodge Carole V. , Bemis‐Dougherty Anita , Everett Sotiria , Fisher Nadine , Fraenkel Liana , Goodman Susan M. , Lewis Janet , Menzies Victoria , Moreland Larry W. , Navarro‐Millan Iris , Patterson Sarah , Phillips Lawrence “Rick” , Shah Neha , Singh Namrata , White Daniel , AlHeresh Rawan , Barbour Kamil E. , Bye Thomas , Guglielmo Dana , Haberman Rebecca , Johnson Tate , Kleiner Anatole , Lane Chris Y. , Li Linda C. , Master Hiral , Pinto Daniel , Poole Janet L. , Steinbarger Kimberly , Sztubinski Daniel , Thoma Louise , Tsaltskan Vlad , Turgunbaev Marat , Wells Courtney , Turner Amy S. , Treadwell Jonathan R. 
Published: May 2023

ObjectiveTo develop initial American College of Rheumatology (ACR) guidelines on the use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐modifying antirheumatic drugs (DMARDs) as part of an integrative management approach for people with rheumatoid arthritis (RA).MethodsAn interprofessional guideline development group constructed clinically relevant Population, Intervention, Comparator, and Outcome (PICO) questions. A literature review team then completed a systematic literature review and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to rate the certainty of evidence. An interprofessional Voting Panel (n = 20 participants) that included 3 individuals with RA achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.ResultsThe Voting Panel achieved consensus on 28 recommendations for the use of integrative interventions in conjunction with DMARDs for the management of RA. Consistent engagement in exercise received a strong recommendation. Of 27 conditional recommendations, 4 pertained to exercise, 13 to rehabilitation, 3 to diet, and 7 to additional integrative interventions. These recommendations are specific to RA management, recognizing that other medical indications and general health benefits may exist for many of these interventions.ConclusionThis guideline provides initial ACR recommendations on integrative interventions for the management of RA to accompany DMARD treatments. The broad range of interventions included in these recommendations illustrates the importance of an interprofessional, team‐based approach to RA management. The conditional nature of most recommendations requires clinicians to engage persons with RA in shared decision‐making when applying these recommendations.
Intrinsically Flexible and Aging Resistant Fluorene‐Based Rod‐Coil Copolymer for Bendable Deep‐Blue PLEDs
Authors: Li Hao , Yu Mengna , Gu Jiabin , Bao Qiujing , Wang Yangcheng , Li Yang , Ma Yan , Bai Lubing , Zhuo Zhiqiang , Zhang Yunlong , Zhang Jingrui , Wang Yeyang , Luo Manman , Liu Yiren , Li Chenghui , Lin Jinyi , Zhang Xinwen , Feng Quanyou , Xie Linghai 
Published: May 2023

AbstractIn the field of flexible light‐emitting display, goal‐oriented intelligent molecular design is used to control various behaviors of molecules, which provides potential for the development of flexible light‐emitting conjugated polymers (LCPs). The introduction of non‐conjugated units into polymer molecules is a key prerequisite for realizing the intrinsic flexibility, but its easy interchain slip will also lead to the formation of interchain excited states, which is detrimental to the efficiency of light‐emitting diodes. Herein, two kinds of fluorene‐based rod‐coil copolymer with stable deep blue emission characteristics is presented and with Commission Internationale de L'Eclairage (CIE) coordinates of (0.18, 0.14) and (0.15, 0.09), respectively. Surprisingly, the copolymer films show efficient blue emission even at 100% tension. Meanwhile, the rod‐coil copolymer possesses better aging resistance compared to rigid π‐conjugated counterparts. Finally, both rigid and flexible light‐emitting diodes based on rod‐coil copolymer exhibit stable deep blue emission, and the G2‐based PLED with CIE coordinates of (0.16, 0.08), which approach National Television System Committee standard blue specification. These results confirm the validity of rod‐coil copolymer design strategy in constructing inherently flexible polymers with deep blue emission, which have great application potential in flexible PLEDs.
Toward High Bias‐Stress Stability P‐Type GaSb Nanowire Field‐Effect‐Transistor for Gate‐Controlled Near‐Infrared Photodetection and Photocommunication
Authors: Sa Zixu , Liu Fengjing , Zhuang Xinming , Yin Yanxue , Lv Zengtao , Wang Mingxu , Zhang Jie , Song Kepeng , Chen Feng , Yang Zai‐xing 
Published: May 2023

AbstractThe bias‐stress instability of nanowires (NWs) field‐effect‐transistors (FETs), originated from the surface trappings, are challenging greatly the functionalization of III‐V group semiconductors in next‐generation electronics and optoelectronics. In this study, the solution‐processed high‐κ oxide dielectric shell is configured uniformly onto the surface of GaSb NWs, contributing to the excellent bias‐stress stability of as‐constructed p‐type NWFETs. Owing to the interdiffusion between Al and Ga, the oxide dielectric shell is Ga‐AlOx. With an optimal oxide dielectric shell, the as‐constructed p‐type GaSb NWFETs show an insignificant attenuation of on‐state current (within 10%) and a negligible negative shift of threshold voltage under 60 min continuous gate bias, which is far better than that of pristine GaSb NWFETs, resulting from the electric double layer effect. Benefiting from the excellent bias‐stress stability, when configured into the near‐infrared photodetector, NWFET exhibits desirable stability and gate‐controlled photodetection behaviors. Idark and Ilight are effectively modulated by gate voltage, resulting in gate‐controlled responsivity and gain under the illumination of 1550 nm laser. In the end, the as‐constructed bias‐stress stability NWFET demonstrates expected gate‐controlled photodetection imaging and photocommunication ability. The strategy of solution‐processed oxide dielectric shell promises high bias‐stress stability NWFETs for gate‐controlled photodetection and photocommunication.
Synthesis of 4‐Furan‐ and 4‐Pyrrol‐3‐yl‐2H‐chromenes from Naturally‐occurring Compounds by Gold(I)‐Catalyed Domino Reactions
Authors: Solas Marta , Renedo Lorena , Suárez‐Pantiga Samuel , Sanz Roberto 
Published: May 2023

AbstractA gold‐catalyzed cascade double cyclization reaction has been designed to synthesize heterobiaryl compounds such as furanyl and pyrrolyl 2H‐chromenes from bis(alkynyl)‐1,2‐diols and 1,2‐amino alcohols. The starting materials are readily available from biomass platform molecules such as α‐hydroxy acids and α‐amino acids. The process involves an initial heterocyclodehydration step enabling the formation of the furan or pyrrole ring, followed by an alkyne hydroarylation to form the chromene core.
Organic Charge‐Transfer Complex based Microstructure Interfaces for Solution‐Processable Organic Thin‐Film Transistors toward Multifunctional Sensing
Authors: Liu Zhiqi , Ju Zhengkun , Ma Shuang , Li Wenju , Chen Jinqiu , Yang Bo , Zhang Jing 
Published: May 2023

AbstractThe development of organic field‐effect transistor (OFET) based sensors is in high demand for flexible electronics. Herein, a new and feasible procedure to grow donor‐acceptor complex microstructures sandwiched between the semiconducting and insulating layers is reported. To realize a well‐distributed, uniform‐sized structure through coating on the gold patterned substrate, the dopping ratio of the organic donor‐acceptor complex in the host polymer is optimized. This method leads to one‐step fabrication of high‐performance semiconductor thin‐films and a microstructured binary system attached to it via successful phase separation. The OFET sensors prepared by this technique demonstrate ideal hole‐transport properties and good pressure response. In addition, the thermal‐sensitivity is also revealed, which enables the device architectures to be multifunctional. This work opens a new avenue to manufacture functional microstructure and flexible OFET based pressure sensors.
Amyloid‐β is a cytokine
Authors: Weaver Donald F. 
Published: May 2023

AbstractThe role of amyloid‐β (Aβ) peptide in human physiology and pathology remains an unresolved subject of study; Aβ’s role in Alzheimer's disease (AD) is particularly controversial. However, before we can more fully appreciate Aβ’s role in AD, an understanding of its normal physiological role(s) must first be attained. This perspective appraises the current literature and concludes that Aβ is a cytokine. This conclusion was arrived at based on a comprehensive listing of 30 characteristic defining structural and functional properties of cytokines followed by a literature precedence‐based demonstration that Aβ possesses all 30 properties; this categorization of cytokine characteristics enabled an organized comparison of cytokines and Aβ, thereby providing systematic justification for classifying Aβ as a cytokine. The conclusion that Aβ is a cytokine enables the merger of two leading hypotheses of AD (amyloid hypothesis and neuroinflammation) into a single process.