bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of Polyethylene Terephthalate Glycol Thermoplastic Material to Functional and Expansion Forces in Orthodontic Applications: An Experimental Study
Authors: Haik Anosh A. , Yassir Yassir A. 
Published: January 2025

Background: While polyethylene terephthalate glycol (PETG) is widely used in orthodontic appliances such as clear aligners and retainers, there is limited experimental data assessing its performance under functional stresses, such as those encountered during dental movements and palatal expansion.Objective: This study aims to evaluate the ability of PETG thermoplastic material to withstand deformation under functional and expansion forces, specifically within the context of orthodontic applications.Subjects and Methods: To estimate the firmness of the screw within the appliance, a universal Instron testing machine was used to record the forces released by each activation of the expander within the upper part of 10 clear modified twin blocks (MTBs) made from PETG and compare it with that released by 10 conventional twin blocks (CTBs). On the other hand, to determine the ability of the thermoplastic appliance to withstand the deformation during functional forces, a three‐point bending test was used to investigate the response of both appliances under static loading. Independent samples t‐test was used to compare the differences between groups.Results: Both CTB and MTB groups follow the same pattern of increase and decrease in the amount of mean load with the CTB group line showing a considerably higher amount of mean load reaching the peak (334.5 N) at turn 25 of screw activation while the peak of mean load for MTB group was equal to 252.6 N at turn 23. There was a statistically significant difference between the CTB and MTB groups in the three‐point bending test (p = 0.001). However, both appliances did not deform at the required force.Conclusions: The MTB can withstand both required expansion and functional load without deformation.Trial Registration: ClinicalTrials.gov identifier: NCT06116500.
Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance
Authors: Ziglari Tahereh , Calistri Nicholas L. , Finan Jennifer M. , Derrick Daniel S. , Nakayasu Ernesto S. , Burnet Meagan C. , Kyle Jennifer E. , Hoare Matthew , Heiser Laura M. , Pucci Ferdinando 
Published: January 2025

Abstract
Senescence is a non-proliferative, survival state that cancer cells can enter to escape therapy. In addition to soluble factors, senescence cells secrete extracellular vesicles (EVs), which are important mediators of intercellular communication. To explore the role of senescent cell-derived EVs (senEVs) in inflammatory responses to senescence, we developed an engraftment-based senescence model in wild-type mice and genetically blocked senEV release in vivo, without significantly affecting soluble mediators. SenEVs were both necessary and sufficient to trigger immune-mediated clearance of senescent cells, thereby suppressing tumor growth. In the absence of senEVs, the recruitment of MHC-II+ antigen-presenting cells to the senescence microenvironment was markedly impaired. Blocking senEV release redirected the primary target of senescent cell signaling from antigen-presenting cells to neutrophils. Comprehensive transcriptional and proteomic analyses identified six ligands specific to senEVs, highlighting their role in promoting antigen-presenting cell–T cell adhesion and synapse formation. Antigen-presenting cells activated CCR2+CD4+ TH17 cells, which appeared to inhibit B cell activation, and CD4+ T cells were essential for preventing tumor recurrence. These findings suggest that senEVs complement the activity of secreted inflammatory mediators by recruiting and activating distinct immune cell subsets, thereby enhancing the efficient clearance of senescent cells. These conclusions may have implications not only for tumor recurrence but also for understanding senescence during de novo carcinogenesis. Consequently, this work could inform the development of early detection strategies for cancer based on the biology of cellular senescence.
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies
Authors: Venkataramani Varun , Yang Yvonne , Ille Sebastian , Suchorska Bogdana , Loges Sonja , Tost Heike , Sahm Felix , Pfister Stefan M. , Trumpp Andreas , Krieg Sandro M. , Kuner Thomas , Wick Wolfgang , Winkler Frank 
Published: January 2025

Abstract
Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contributing to brain tumor initiation, progression, and resistance, including synaptic connections between neurons and cancer cells, paracrine neuro-cancer signaling, and cancer cells’ intrinsic neural properties. We explain the basic and clinical–translational relevance of these findings, identify unresolved questions and particularly interesting future research avenues, such as central nervous system neuro-immunooncology, and discuss the potential transferability to extracranial cancers. Lastly, we conceptualize ways toward clinical trials and develop a roadmap toward neuroscience-instructed brain tumor therapies.
Significance: Neural influences on brain tumors drive their growth and invasion. Herein, we develop a roadmap to use these fundamentally new insights into brain tumor biology for improved outcomes.
Figure 4 from Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
Authors: Sonowal Himangshu , Rice William G. , Bejar Raphael , Byun Joo-Yun , Jung Seung Hyun , Sinha Ranjeet , Howell Stephen B. 
Published: January 2025

<p>Characterization of TUS/R MOLM-14 cell lines. <b>A,</b> Effect of TUS on the growth rate of parental MOLM-14 cells and four sublines selected for growth in 75 nmol/L TUS (<i>P</i> < 0.01 vs. MOLM-14 parental cells for all TUS/R lines). <b>B,</b> Change in TUS IC<sub>50</sub> of resistant cells when grown in TUS-free media. Data are presented as mean ± SEM from three-independent experiments. Western blot analysis documenting levels of selected kinases in (<b>C</b>) TUS-resistant lines 3 and 4 (<b>D</b>) after acute exposure to 75 nmol/L TUS for the indicated time. Representative data from two Western blots are shown.</p>
Deconstructing Temporal Stages of Prosocial and Antisocial Risky Decision-making in Adolescence
Authors: Haromi Morteza Erfani , Golbabaei Soroosh , Borhani Khatereh 
Published: January 2025

Abstract
Risk-taking is a prominent aspect of adolescent behavior. A recent neurodevelopmental model suggests that this trait could influence prosocial and antisocial decision-making, proposing a new category known as prosocial and antisocial risk-taking. The primary objective of this study was to examine the electrophysiological underpinnings of prosocial and antisocial risk-taking in adolescence, a developmental period characterized by elevated risky, prosocial, and antisocial decisions. To this end, 32 adolescents aged 13–19 years completed a modified dictator game to choose between three options, representing prosocial and antisocial risk-taking constructs and a risk-free fair one. At the behavioral level, adolescents favored antisocial risky decisions over prosocial risky ones. ERP results at the electrophysiological level in the response selection stage demonstrated that decision preceding negativity was more negative-going before making prosocial risky decisions than other decisions. During the feedback evaluation stage, feedback-related negativity was the least negative after selecting the antisocial risky option and receiving successful feedback. However, choosing the fair option and receiving neutral feedback resulted in the most negative feedback-related negativity. Moreover, P300 showed the most positive mean amplitude following the selection of the antisocial risky option and facing successful feedback, with the lowest positive amplitude observed after choosing the fair option and encountering neutral feedback. These results underscore the distinct electrophysiological underpinnings associated with prosocial and antisocial decisions involving risks.
CLAPnq:

C

ohesive

L

ong-form

A

nswers from

P

assages in Natural Questions for RAG systems
Authors: Rosenthal Sara , Sil Avirup , Florian Radu , Roukos Salim 
Published: January 2025

Abstract
Retrieval Augmented Generation (RAG) has become a popular application for large language models. It is preferable that successful RAG systems provide accurate answers that are supported by being grounded in a passage without any hallucinations. While considerable work is required for building a full RAG pipeline, being able to benchmark performance is also necessary. We present CLAPnq, a benchmark Long-form Question Answering dataset for the full RAG pipeline. CLAPnq includes long answers with grounded gold passages from Natural Questions (NQ) and a corpus to perform either retrieval, generation, or the full RAG pipeline. The CLAPnq answers are concise, 3x smaller than the full passage, and cohesive, meaning that the answer is composed fluently, often by integrating multiple pieces of the passage that are not contiguous. RAG models must adapt to these properties to be successful at CLAPnq. We present baseline experiments and analysis for CLAPnq that highlight areas where there is still significant room for improvement in grounded RAG. CLAPnq is publicly available at https://github.com/primeqa/clapnq.
‘A Considerable Disturbance in the Holy Place’: Ritual Mourning as Efficacious Spatial Subversion in 3 Maccabees
Authors: Krause Andrew R. 
Published: January 2025

Abstract
In 3 Maccabees, the timely prayers of two priests, Simon and Eleazar, save the people and their various holy spaces. However, one related ritual element that is often overlooked is the socially disruptive mourning rites of vulnerable women. These performances immediately precede both highly efficacious prayers and accompany the arrests of those Jewish people who resisted Ptolemy’s decree. The cities, their various urban social functions, childcare, and marital rituals are all disrupted in a hyperbolic description of the disorder caused by Ptolemy’s wanton attacks on explicitly Jewish spaces. In all three cases, the texts present a highly stylized description of mourning performed in ways that disrupt and subvert the spatial expectations of the urban environs of the narrative’s setting. This disorder is best understood as a ritual focusing that leads to the dramatic prayers of the two priests that counteract Ptolemy’s spatial trespasses.
Jesus’s ‘Sorrow’ (Matt. 26.37–8)? Exploring the Connotations of a Tabooed Emotion
Authors: White B.G. 
Published: January 2025

Abstract
The attribution of λύπη to Jesus in Matthew’s Gethsemane (26.37–38) – typically translated as ‘sorrow’ or ‘grief’ – is often understood as an attempt to humanize Jesus’s anguish with a relatively benign emotion. However, interpreters rarely offer detailed analyses of the term or its connotations, particularly its physical intensity and how it readily triggered condemnation. This article employs semantic theory and affect theory to gain a fuller perspective on Jesus’s λύπη. It surveys the use of λυπ- words in ancient sources, classifies Jesus’s λύπη as ‘deep despair’, and highlights how the emotion was widely regarded as unacceptable for an honorable person, let alone a messiah. Finally, it traces allusions to the emotion within the passion narrative and offers suggestions for interpretation, including the irony that Jesus’s seemingly irredeemable qualities allow him to identify with those in emotional turmoil and more fully become Israel’s Immanuel.
Distinct Effect of the Warming Trend on Extreme Mei-Yu Rainfall in June and July over East Asia: Perspectives from Observation and Simulation
Authors: Huang An-Yi , Hong Chi-Cherng , Chen Chao-An , Hsu Huang-Hsiung , Tseng Wan-Ling , Hsu Pei-Chun , Lo Min-Hui , Chiang Jun 
Published: January 2025

Abstract
The record mei-yu rainfall occurred in the Yangtze–Huai River valley (YHRV) and Japan regions in the early summer (June–July) of 2020 and devastated these regions. Whereas several studies had been devoted to the physical processes behind this climate extreme, the impact of the upward trend in the ocean and atmosphere was less investigated. In this study, the potential effect of the linear trend on the mei-yu rainfall extreme was assessed by comparing the 2020 event with a 1998 extreme event. The distinction between June and July was the focus. In June, a significant increasing rainfall trend, accompanied by an enhanced low-level southwesterly, was identified over south China. The linear trend of precipitation also contributed substantially to the total mei-yu rainfall in 2020, which was not observed in 1998. The moisture flux budget indicates that the climatological moisture transport by the linear trend of southwesterly contributes substantially to the extreme rainfall. In contrast to June, the mei-yu rainfall in July over YHRV, accompanied by a low-level easterly trend, showed a decreasing trend. Consequently, the linear trend does not contribute to the extreme rainfall. The numerical experiments, consistent with observations, indicated that the sea surface temperature (SST) warming trend contributed to the extreme mei-yu rainfall in June. This effect was not observed in July.
The Effectiveness and Safety of Beta Antagonists in Patients With Burns: An Updated Meta-Analysis
Authors: Bhatti Aribah , Shah Sanaullah , Shahzaib Muhammad , Nadeem Muhamad Amaan , Shaikh Asim , Rehman Habib Ur , Rizvi Syed Saaid , Khan Maimoona , Singh Jasninder Dhaliwal , Mahfooz Faisal , Aftab Rameel Muhammad , Rao Dua Fatima Zaheer , Chachar Muhammad Azhar 
Published: January 2025

Aims The purpose of this systematic review was to assess the safety and effectiveness of beta antagonists for improving clinical care in burn patients, compared to placebo. Methods Articles from randomized-controlled trials were identified by a literature search on PubMed and Cochrane. We included relevant trials involving patients with burn. Trials were eligible if they evaluated propranolol and compared to usual care or placebo. We conducted a meta-analysis using a random-effects model. Results A total of 2114 patients were included from 14 RCTs. Beta-blocker-treated patients had decreased heart rates (WMD = −14.73, 95% CIs = [−19.14, −10.32]), mean arterial pressure (WMD = −2.76, 95% CIs = [−3.81, −1.70]), rate pressure product (WMD = −1.13, 95% CIs = [−1.56, −0.71]), reduced time for wound healing (WMD = −5.08, 95% CIs [−8.97, −1.18]), and lower resting energy expenditure (WMD = −168.83, 95% CIs [−232.03, −105.63]). However, use of beta-blockers did not reduce mortality rate (WMD = 0.98, 95% CIs [0.68, 1.41]), incidence of sepsis (RR = 0.82, 95% CIs = [0.50, 1.35]), or length of stay in hospital (WMD = −1.50, 95% CIs [−4.76, 1.77]) compared with placebo. Conclusion Our findings indicate that the administration of propranolol to burned patients does not contribute to increased mortality rates, reduced length of hospital stays, or heightened sepsis occurrence. It demonstrates a protective effect on heart function by reducing heart rate, resting energy expenditure, rate pressure product, and wound healing. More randomized-controlled and multi-center studies are needed to effectively establish the use of beta antagonists in burn patients.
Mental health help-seeking behaviours among children and young people from culturally and linguistically diverse communities in a multicultural urban Australian population
Authors: John James Rufus , Khan Jahidur Rahman , Middleton Paul M , Huang Yao , Lin Ping-I , Hu Nan , Jalaludin Bin , Chay Paul , Lingam Raghu , Eapen Valsamma 
Published: January 2025

Objective: This study aimed to investigate the help-seeking behaviours among children and young people (CYP) from culturally and linguistically diverse (CALD) backgrounds for mental health (MH) needs in a multicultural Australian population. Methods: We analysed the electronic medical records (eMR) of 8135 MH-related emergency department (ED) encounters of CYP aged up to 18 years across six public hospitals in the South Western Sydney Local Health District, Australia, from January 2016 to April 2022. Urgency of MH care was grouped into high priority (triage categories 1 and 2, needing to have treatment within 10 minutes) and low-to-moderate (triage categories 3–5, needing to have treatment within 30–120 minutes) presentations. Multilevel logistic regression models adjusted for key covariates and patient level clustering examined the relationship between CALD status and urgency of MH care. We also assessed the combined effects of gender and CALD status, as well as CALD status and residential area socioeconomic status, on urgent ED care. Results: About 8.3% of all MH-related ED presentations during the 6-year period were classified as high priority. The odds of high-priority MH ED care were 2.03-fold higher for CALD CYPs compared to non-CALD CYPs (adjusted odds ratio (AOR): 2.03, 95% confidence interval [CI] = [1.46–2.82]). Furthermore, an added increase in the odds of seeking urgent MH care for CYPs who belong to multiple risk groups was observed among CALD male CYPs (AOR: 2.96, 95% CI = [1.81–4.85]) and those living in disadvantaged areas (AOR: 2.36, 95% CI = [1.59–3.49]). Conclusion: The findings of this study highlight the need for culturally appropriate services aimed at prevention and early intervention targeted at CYP from CALD backgrounds to avoid crisis presentations.
The Effects of Trait Anger on Proactive and Reactive Online Aggression: The Mediating Role of Hostile Attribution Bias and the Moderating Role of Self-Control
Authors: Chen Dan , Sun Hongmei 
Published: January 2025

Individuals’ involvement in reactive and proactive online aggression has garnered widespread concern from various societal sectors, marking it as a critical indicator of individual social development. The influencing factors that might exist for both reactive and proactive online aggression have been little explored. Understanding these could help us develop more effective intervention strategies, targeting individuals who exhibit both types of aggression. Structural Equation Modeling was used to examine the relationship between trait anger and hostile attribution bias on reactive and proactive online aggression. A total of 1075 college students (Mage = 19.96 ± 1.54 years) completed assessments related to trait anger, hostile attribution bias, self-control, and reactive and proactive online aggression. Hostile attribution bias partially mediates the association between trait anger and both forms of aggression, while self-control moderates the association between trait anger and hostile attribution bias and both types of aggression. Illustratively, individuals with high self-control can better buffer both the direct effects of trait anger and the indirect effects of hostile attribution bias on reactive and proactive online aggression. This result provides empirical support for the Integrative Cognitive Model, ICM. Our findings may provide educational practitioners with important information regarding intervention design.
Exploring Inclusion by Creating Inclusion: A World Café Among Nurse Scientists
Authors: Zadvinskis Inga M. , Knudsen Élise N. Arsenault , Falkenberg Olson Ann C. , Eustace Rosemary W. , Albert Nancy M. , Klein Colleen J. , Bohr Nicole L. , Guthrie Lisa E. , Libster Martha Mathews 
Published: January 2025

Background: The concept of inclusion within diversity, equity, and inclusion has broad meanings and implications and has not been explored in nursing through a World Café. Purpose: To describe the process and experiences of 9 nurse scientists who hosted a World Café focused on inclusion, to share participants’ insights, and to offer considerations to advance inclusion in nursing. Approach: We hosted and encouraged active participation in a World Café that focused on 7 inclusion topics in nursing during the 2024 Midwestern Nursing Research Society Annual Research Conference. During the 90-min World Café, 40 participants (“members”) engaged in iterative rounds of small group dialogue, moving from table to table every 10 min and randomly changing groups. Table hosts welcomed new members, provided background information, and asked probing questions about topics related to inclusion. Members shared insights verbally and through creative expression using colored markers/pencils or craft supplies and creating images on paper tablecloths. Table hosts used notes, photographs of words and images from the paper tablecloths, and collective post-Café reflections to synthesize insights regarding inclusion. Discoveries: Across all topics, members stated that inclusion requires connecting as human beings, creating welcoming spaces, being open to others, and actively listening. Table hosts described the World Café process as engaging, invoking, and inspiring. Hosts found the World Café process itself to be inclusive, inviting diverse perspectives, and gleaning insights about inclusion in nursing. Considerations generated from this World Café offer tangible behaviors to promote inclusion across various nursing topics, roles, and settings.
Arthroscopic Repair of Bursal-Sided Partial-Thickness Rotator Cuff Tears: Literature Review and Meta-analysis
Authors: Dalmas Yoann , Hao Kevin A. , Barret Hugo , Mansat Pierre , Bonnevialle Nicolas 
Published: January 2025

Background: The surgical management of bursal-sided partial-thickness rotator cuff tendon tears is controversial. The 2 methods used are in situ repair (ISR), preserving the contingent of intact articular tendon fiber, or tear completion before repair (TCBR) according to the operating surgeon's usual technique. No study with sufficient power has demonstrated a superior technique. Hypothesis: The 2 techniques are equivalent in terms of clinical outcome and tendon healing. Study Design: Systematic literature review and meta-analysis; Level of evidence, 4. Methods: A systematic review was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations on the PubMed, Embase, and Cochrane Library databases from January 2003 through March 2023. Only articles dealing with Ellman grade 3 bursal-sided tears with a minimum follow-up of 1 year were included. Primary endpoints were American Shoulder and Elbow Surgeons and Constant-Murley scores, pain on a visual analog scale, and retear rate. The secondary endpoint was recovery of active mobility. Results: Twelve studies were included with overlap of 3, leaving 8 ISR studies (360 patients; mean follow-up, 30 months) and 7 TCBR studies (224 patients; mean follow-up, 51 months) for statistical analysis. No significant clinical differences were found when comparing mean American Shoulder and Elbow Surgeons (92.2 [95% CI, 88.1-96.2] vs 88.9 [95% CI, 85.8-92.0]; P = .21), Constant-Murley (86.3 [95% CI, 81.5-91.0] vs 91.8 [95% CI, 88.1-95.6]; P = .07), and visual analog scale (0.8 [95% CI, 0.2-1.4] vs 1.0 [95% CI, 0.5-1.4]; P = .63) scores in the TCBR and ISR groups, respectively. The retear rate was 6.8% (95% CI, 3.1%-14.3%) in the TCBR group and 9.5% (95% CI, 6.1%-14.3%) in the ISR group ( P = .46). Active mobility was also comparable. Conclusion: This meta-analysis suggests that ISR and TCBR provide comparable results in the surgical management of Ellman grade 3 bursal-sided partial-thickness rotator cuff tears.