bluuebunny/crossref_metadata_2025_split huggingface dataset:
A continuum damage model for creasing and folding of paperboard
Authors: Robertsson Kristofer , Jacobsson Erik , Wallin Mathias , Borgqvist Eric , Ristinmaa Matti , Tryding Johan 
Published: September 2023

AbstractA continuum damage framework is proposed for modelling the delamination process occurring in paperboard during mechanical loading. The main application of interest is line creasing and subsequent line folding used in package forming. To adequately capture creasing and folding, a continuum damage framework that uses a single isotropic damage variable that evolves with the plastic strains associated with out‐of‐plane shearing is used. The damage evolution is calibrated against folding experiments for a specific reference mesh, and a simple scaling strategy is proposed to reduce the inherent mesh dependency. To highlight the potential of the proposed model, an illustrative 3D example is considered where a paperboard sheet is creased by two plates and folded to resemble the corner of a package.
Comparison of threshold tuning methods for predictive monitoring
Authors: von Stackelberg Paulina , Goedhart Rob , Birbil Ş. İlker , Does Ronald J. M. M. 
Published: September 2023

AbstractPredictive monitoring techniques produce signals in case of a high predicted probability of an undesirable event, such as mortality, heart attacks, or machine failure. When using these predicted probabilities to classify the unknown outcome, a decision threshold needs to be chosen in statistical and machine learning models. In many cases, this is set to 0.5 by default. However, this may not lead to an acceptable model performance. To mitigate this issue, different threshold optimization approaches have been proposed in the literature. In this paper, we compare existing thresholding techniques to achieve a desired false alarm rate, and also evaluate the corresponding precision and recall performance metrics. A simulation study is conducted and a real‐world example on a medical dataset is provided.
Responsive materials based on coordination bonds
Authors: Chen Shi‐Yi , Zhao Zi‐Han , Li Cheng‐Hui , Li Quan 
Published: September 2023

AbstractResponsive materials can respond to different external stimuli by changing their chemical or/and physical properties, thus being useful for various applications such as drug delivery, bioimaging, actuators, and sensors. A common strategy for constructing responsive materials is to introduce dynamic covalent bonds or noncovalent interactions into polymer systems. Compared with noncovalent interactions and other covalent bonds, coordination bonds have the peculiarity that their bond strength and dissociation rate can be tuned to a greater extent. Such tunability makes coordination bonds uniquely advantageous in constructing stimuli‐responsive materials. Herein, we summarize the recent progress of responsive materials based on coordination bonds that are classified into seven categories, that is, thermo‐responsive, photo‐responsive, electro‐responsive, mechano‐responsive, chemo‐responsive, pH‐responsive, and other responsive materials, according to the type of external stimuli. The corresponding mechanism, design strategy, and research status of each category are comprehensively summarized. Finally, the prospects and challenges for the development of stimuli‐responsive materials based on coordination bonds are discussed.
Assessment of adaptive optics‐corrected optical links statistics from integrated turbulence parameters through a Gaussian process metamodel
Authors: Klotz Emile , Lefebvre Sidonie , Vedrenne Nicolas , Musso Christian , Poulenard Sylvain , Fusco Thierry 
Published: September 2023

SummaryWith the development of free space optical links (FSO) for space‐ground communications comes the need to mitigate the effects of the atmospheric turbulence to guarantee a lossless connection. By having a network of addressable ground stations, we want to guarantee to always target a point where the link is available. Assuming atmospheric transmission is managed thanks to site diversity, we focus only on the influence of atmospheric turbulence on the signal injected into a single mode fiber on the downlink. The use of adaptive optics (AO) is assumed to avoid turbulence‐induced signal disruptions and enable a sufficiently high level of received signal for data transmission. Up to now, AO performance adequate assessment required the knowledge of high‐resolution
and wind profiles. With the advent of integrated atmospheric parameters measurement instruments, we investigate here the possibility to estimate AO‐corrected performance from a limited number of integrated parameters. In this paper, we propose to use a Gaussian process metamodel to assess the statistics of the received optical power after an AO correction. Taking as input only four integrated parameters of the turbulence profile and associated wind profile, which can be measured with simple instruments, the estimation error on the value of the 1% quantile of the received optical power is inferior to
. We also demonstrate the possibility to estimate the half correlation time of the received optical power using the same integrated parameters.
Ferroelectric Size Effects on Statics and Dynamics of Domain Wall
Authors: Kale Somnath , Petraru Adrian , Kohlstedt Hermann , Soni Rohit 
Published: September 2023

AbstractDomain walls separating differently oriented polarization regions of ferroelectric materials are known to greatly impact nanoscale materials and device functionalities. Though the understanding of size effects in ferroelectric nanostructures has progressed, the effect of thickness downsizing on domain wall scaling behavior has remained unexplored. Using piezoresponse force microscopy, epitaxial BaTiO3 film thickness size (2–90 nm) effects on the critical scaling universality of the domain wall dynamical creep and static roughness exponents including dimensionality is demonstrated. Independently estimated static roughness exponents ranging between 0.34 and 0.28 and dynamical creep exponents transition from 0.54 to 0.22 elucidate the domain wall dimensionality transition from two‐ to quasi‐one‐dimension in the thickness range of 10–25 nm, which is later validated by evaluating effective dimensionality within the paradigm of random‐bond universality. The observed interdimensional transition is further credenced to the compressive strain and long‐range strain–dipolar interactions, as revealed by the structural analyses and additional measurements with modified substrate‐induced strain. These results provide new insights into the understanding of size effects in nanoscale ferroelectricity, paving the way toward future nanodevices.
NaYF4:Yb/Er@Mn3O4@GOX Nanocomposite for Upconversion Fluorescence Imaging and Synergistic Cascade Cancer Therapy by Apoptosis and Ferroptosis
Authors: Chen Yinyin , Li Haoran , Hou Baoshan , Wu Aimin , Wu Wei , Li Chunxia , Wang Hao , Chen Daiwen , Wang Xianxiang 
Published: September 2023

AbstractThe cell elimination strategy based on reactive oxygen species (ROS) is a promising method for tumor therapy. However, its efficacy is significantly limited by ROS deficiency caused by H2O2substrate deficiency and up‐regulation of cellular antioxidant defense induced by high glutathione (GSH) content in tumor cells. To overcome these obstacles, a multifunctional self‐cascaded nanocomposite: glucose oxidase (GOX) loaded NaYF4:Yb/Er@Mn3O4(UC@Mn3O4, labeled as UCMn) is constructed. Only in tumor microenvironment, it can be specifically activated through a series of cascades to boost ROS production via a strategy of open source (H2O2self‐supplying ability). The increased ROS can enhance lipid peroxidation and induce tumor cell apoptosis by activating the protein caspase. More importantly, the nanozyme can consume GSH to inhibit glutathione peroxidase 4 (GPX4) activity, which limits tumor cell resistance to oxidative damage and triggers the tumor cell ferroptosis. Therefore, this strategy is expected to overcome the resistance of tumor to oxidative damage and achieve efficient oxidative damage of tumor. Further, degradation of the Mn3O4layer induced by GSH and acidic environment can promote the fluorescence recovery of UC fluorescent nuclear for tumor imaging to complete efficient integration of diagnosis and treatment for tumor.
Comprehensive Neurotoxicity of Lead Halide Perovskite Nanocrystals in Nematode Caenorhabditis elegans
Authors: Ngo Loan Thi , Huang Wen‐Tse , Chan Ming‐Hsien , Su Ting‐Yi , Li Chien‐Hsiu , Hsiao Michael , Liu Ru‐Shi 
Published: September 2023

AbstractTo date, all‐inorganic lead halide perovskite quantum dots have emerged as promising materials for photonic, optoelectronic devices, and biological applications, especially in solar cells, raising numerous concerns about their biosafety. Most of the studies related to the toxicity of perovskite quantum dots (PeQDs) have focused on the potential risks of hybrid perovskites by using zebrafish or human cells. So far, the neurotoxic effects and fundamental mechanisms of PeQDs remain unknown. Herein, a comprehensive methodology is designed to investigate the neurotoxicity of PeQDs by using Caenorhabditis elegans as a model organism. The results show that the accumulation of PeQDs mainly focuses on the alimentary system and head region. Acute exposure to PeQDs results in a decrease in locomotor behaviors and pharyngeal pumping, whereas chronic exposure to PeQDs causes brood decline and shortens lifespan. In addition, some abnormal issues occur in the uterus during reproduction assays, such as vulva protrusion, impaired eggs left in the vulva, and egg hatching inside the mother. Excessive reactive oxygen species formation is also observed. The neurotoxicity of PeQDs is explained by gene expression. This study provides a complete insight into the neurotoxicity of PeQD and encourages the development of novel nontoxic PeQDs.
Microwave Assisted Cooking Improves Edible Quality of Germ Rice: Insights of Multiscale Starch Microstructure, In Vitro Digestion, and Flavor
Authors: Yu Jiahao , Li Yanan , Ye Yufen , Zhang Jianming , Shao Ping 
Published: September 2023

AbstractGerm rice is a moderately processed products with high germ retention rate (>80%). Electric rice‐cooker and microwave cooking as the most common cooking methods have different effects on starch microstructures, digestibility, rheological behavior, texture, and flavor of germ rice. Microwave‐cooked germ rice contains more short‐range ordered structures and higher crystallinity than electric rice‐cooker cooked germ rice. The starch digestibility of germ rice (i.e., rapidly digestible starch) cooked by microwave under different power and time (50.74%–52.47%) is lower than that of electric rice‐cooker cooked by two modes (60.52%–60.82%). The rheology (modulus and shear viscosity) of germ rice treated by electric rice‐cooker is higher than that treated by microwave. Microwave‐cooked germ rice has lower adhesiveness (164–212 g s) than that cooked in electric rice‐cooker (286–295 g s). Aldehydes are the most abundant volatile components, and play a very important role in germ rice flavor. Microwave cooking can reduce the digestibility of starch and improve the flavor of cooked germ rice. Microwave is expected to be a promising cooking technique for germ rice cooking.
Immobilization of Xylanase onto Starch Nanoparticles: A Reusable and Robust Nanobiocatalyst for Juice Clarification
Authors: Dik Gamze , Bakar Büşra , Ulu Ahmet , Köytepe Süleyman , Ateş Burhan 
Published: September 2023

AbstractNanoparticles (NPs) have attracted interest recently as a promising support for the immobilization of enzymes.Xylanase (Xyl) has been utilized in the food industry for several purposes. To improve its stability and reusability,starch NPs (SNPs)are synthesized and assessed for Xyl immobilization for the first time. The characterization results reveal that SNPs are successfully synthesized and Xyl@SNPs are effective as the immobilization carrier. The Xyl is immobilized on SNPs under optimized conditions leading to 91% immobilization efficiency. A shift in optimum pH (from 6.0 to 8.0) and temperature (from 70 to 60 °C) of Xyl is observed after immobilization. The Xyl@SNPs possess improve pH stability and thermal stability as well as operational stability. The Xyl@SNPs are easily reutilized and the residual activity is still higher than 62% after seven times. More importantly, the Xyl@SNPs have a lower Km value and enhance affinity for the substrate compared to the free Xyl. Additionally, the clarity of orange juice is increased by 76.0% by using Xyl@SNPs after 2 h incubation at 60 °C, pH 8.0. These positive results show promising support for the Xyl immobilization of SNPs, confirming that this immobilized enzyme‐based strategy is an effective technique for rapid clarification of targeted juices.
Hydrochloric acid resistance of mortars incorporating waste glass powder as cementitious materials
Authors: Sharifi Yasser , Visrudi Hasan Najafi 
Published: September 2023

AbstractDespite numerous studies conducted on the potential of waste materials as cement substitutes, the resistance of mortars comprising such blended cementitious materials against acidic environments has seldom been investigated. This paper presents an investigation into the potential of waste glass powder (WGP) as a replacement for cement in enhancing the mechanical, and durability of cementitious materials subjected to acidic environments. The study examines the impact of WGP on the resistance of mortar to hydrochloric acid solution attack, with specimens containing 0%, 5%, 10%, 15%, 20%, 25%, and 30% WGP produced as cement substitutes. The tests were conducted on the cement mortar and paste after water curing for 7, 14, 28, 42, and 56 days. Initially, the pozzolanic activity index assessment, fresh density, water absorption, and compressive strengths during water curing times were evaluated. Subsequently, the performance of mortars, when subjected to hydrochloric acid solutions, was assessed, including mass loss, residual compressive strength, visual inspection, and microstructure features during 8 weeks of immersion in hydrochloric acid. The results of the study indicated that the incorporation of WGP led to improved hydrochloric acid resistance in the mortar. Furthermore, an increase in WGP content resulted in a reduced reduction in compressive strength against hydrochloric acid attacks as the ages progressed. The study revealed that the mortar containing 5% WGP as a cement substitute had the highest compressive strength compared to other specimens, and using 10% WGP as a supplementary cementitious material was comparable to the control mixture. Finally, the x‐ray diffraction pattern indicated that the specimen containing 5% WGP had a lower intensity of portlandite peaks than the reference specimen.
A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho‐1 signaling pathways in SD rats with doxorubicin‐induced acute cardiotoxicity
Authors: Yuan Hsieh Dennis jine , Islam Md. Nazmul , Kuo Wei‐Wen , Shibu Marthandam Asokan , Lai Chin‐Hu , Lin Pi‐Yu , Lin Shinn‐Zong , Chen Michael Yu‐Chih , Huang Chih‐Yang 
Published: September 2023

AbstractOhwia caudata (Thunb.) H. Ohashi (Leguminosae) also called as “Evergreen shrub” and Artemisia argyi H.Lév. and Vaniot (Compositae) also named as “Chinese mugwort” those two‐leaf extracts frequently used as herbal medicine, especially in south east Asia and eastern Asia. Anthracyclines such as doxorubicin (DOX) are commonly used as effective chemotherapeutic drugs in anticancer therapy around the world. However, chemotherapy‐induced cardiotoxicity, dilated cardiomyopathy, and congestive heart failure are seen in patients who receive DOX therapy, with the mechanisms underlying DOX‐induced cardiac toxicity remaining unclear. Mitochondrial dysfunction, oxidative stress, inflammatory response, and cardiomyocytes have been shown to play crucial roles in DOX‐induced cardiotoxicity. Isoliquiritigenin (ISL, 10 mg/kg) is a bioactive flavonoid compound with protective effects against inflammation, neurodegeneration, cancer, and diabetes. Here, in this study, our aim is to find out the Artemisia argyi (AA) and Ohwia caudata (OC) leaf extract combination with Isoliquiritigenin in potentiating and complementing effect against chemo drug side effect to ameliorate cardiac damage and improve the cardiac function. In this study, we showed that a combination of low (AA 300 mg/kg; OC 100 mg/kg) and high‐dose(AA 600 mg/kg; OC 300 mg/kg) AA and OC water extract with ISL activated the cell survival‐related AKT/PI3K signaling pathway in DOX‐treated cardiac tissue leading to the upregulation of the antioxidant markers SOD, HO‐1, and Keap‐1 and regulated mitochondrial dysfunction through the Nrf2 signaling pathway. Moreover, the water extract of AA and OC with ISL inhibited the inflammatory response genes IL‐6 and IL‐1β, possibly through the NFκB/AKT/PI3K/p38α/NRLP3 signaling pathways. The water extract of AA and OC with ISL could be a potential herbal drug treatment for cardiac hypertrophy, inflammatory disease, and apoptosis, which can lead to sudden heart failure.
Suspected robenacoxib‐induced liver injury in a dog
Authors: Pena‐Ramos Jorge , Finch Natalie Clare , Sanchez‐Redondo Sonia 
Published: September 2023

AbstractA 9‐year six‐month‐old, female, neutered border collie was referred to a tertiary referral hospital to further investigate a 17‐day history of anorexia, lethargy and increased liver enzyme activities. The dog had been receiving robenacoxib (1 mg/kg) alongside omeprazole (1 mg/kg), both given once daily for 55 days, for the treatment of degenerative joint disease. There was no history of toxin exposure. Liver enzyme activities were within reference intervals before the course of nonsteroidal anti‐inflammatory drugs. Investigations revealed increased liver enzyme activities, mainly alanine aminotransferase. Histopathological analysis of liver biopsies taken 17 days after the onset of the clinical signs revealed mild portal lymphoplasmacytic, histiocytic and minimally neutrophilic inflammation. Robenacoxib‐induced liver injury was suspected. Liver enzyme activities gradually returned to normal after discontinuation of the drug. This report raises awareness about possible liver injury associated with robenacoxib when prescribing long‐term treatment with the drug.
Diagnosis of intracranial neoplasia by transcranial ultrasound in two pet rats (Rattus norvegicus)
Authors: Ardiaca García María , Montesinos Barceló Andrés , Bonvehí Nadeu Cristina , Romero Herrera Paula , Plaza Serrano Pedro 
Published: September 2023

AbstractThis article describes the use of transcranial ultrasound for confirmation of intracranial neoplasia in two pet rats. The diagnosis was confirmed by means of a contrast‐enhanced computed tomography scan in one case, and postmortem examination and histopathology in the other. Pituitary adenoma is a common condition in rats and, until now, advanced diagnostic imaging, such as computed tomography or magnetic resonance imaging, was required to support a presumptive diagnosis of an intracranial mass based on anamnesis and clinical signs. Despite some limitations of image quality, ultrasound provided images of diagnostic quality in both cases in this study. Compared to computed tomography or magnetic resonance imaging, transcranial ultrasound is a less expensive, less time consuming and more readily available diagnostic imaging technique that can be valuable to aid diagnosis of intracranial tumours in pet rats.
Chemical reaction and radiation impact on unsteady free convective flow through a porous medium past an infinite oscillatory vertical plate
Authors: Saikia Dibya Jyoti , Ahmed Nazibuddin 
Published: September 2023

AbstractThe current investigation is concerned with the effect of chemical reactions and radiation on unsteady free convective flow through a porous medium via an infinitely oscillating vertical plate. The primary goal of this study is to investigate the effects of first‐order homogeneous chemical reactions and thermal radiation on mass flow and heat transmission characteristics. The closed‐form Laplace transformation method is used to obtain exact solutions to the governing equations for concentration, energy and momentum. The impact of various non‐dimensional parameters on fluid velocity, temperature and concentration is graphically depicted. Furthermore, 3‐dimensional surface plots for the Nusselt number and Sherwood number are provided, and the equation for skin friction is derived and demonstrated in tabular form. Investigation simulates that the skin friction increases as the chemical reaction parameter hikes, whereas the fluid concentration reduces as the chemical reaction parameter increases. Further, it was revealed that the augmentation of the radiation parameter decreased the temperature and velocity pattern. It is seen that the primary and secondary velocities reduce due to the increment of the chemical reaction parameter.
Impact of climate change on the distribution and habitat suitability of the world’s main commercial squids
Authors: Guerreiro Miguel Fernandes , Borges Francisco Oliveira , Santos Catarina Pereira , Xavier José Carlos , Hoving Henk-Jan , Rosa Rui 
Published: September 2023

AbstractClimate change is expected to have major negative effects on marine life across phylogenetic groups. Cephalopods, however, have life history characteristics that suggest they may benefit from certain climate change scenarios. Of all cephalopods, squids reach the greatest biomasses; as a result, they are of substantial importance for human and predator consumption. To test the hypothesis that the effects of climate change are beneficial for commercial squid, we used species distribution models on climate scenarios for the period between 2000 and 2014, as well as the years 2050 and 2100 (RCP [representative concentration pathway] 2.6, 4.5, 6.0, and 8.5; CMIP5). Our results suggest that consequences of climate change scenarios are species specific. In the North Pacific and Northwest Atlantic, squid’s habitat suitability may increase (from + 0.83% [Doryteuthis pealeii] to + 8.77% increase [Illex illecebrosus]), while it is predicted to decrease in other regions (from  − 1.03% [Doryteuthis opalescens] to − 15.04% decrease [Loligo reynaudii]). Increases in habitat suitability occurred mostly at higher latitudes (north of 50° N), while suitable habitat decrease was predicted for the tropical regions. These shifts in future habitat suitability were stronger under harsher emission scenarios. Starting in 2050 (with RCP scenarios 4.6, 6.0 and 8.5), as a result of warming of the Arctic, squid habitat may increase along both coasts of North America. In the Southern Hemisphere, squids may lose habitat with no poleward habitat alternatives to move into. Contrary to our hypothesis, these commercial squid do not stand to benefit from climate change. Since these squid are an important food source for marine megafauna and humans, it is imperative that climate change biogeographic impacts are considered for a sustainable management of this important group of molluscs.