bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Radix Bupleuri From Different Geographic Origins Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Support Vector Machine Algorithm
Authors: Zhang Zheng-Yong , Zhao Ya-Ju , Guo Fang-Jie , Wang Hai-Yan 
Published: May 2023

Abstract

Background
The geographic origin of Radix bupleuri is an important factor affecting its efficacy, which needs to be effectively identified.

Objective
The goal is to enrich and develop the intelligent recognition technology applicable to the identification of the origin of traditional Chinese medicine.

Method
This article establishes an identification method of Radix bupleuri geographic origin based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and support vector machine (SVM) algorithm. The Euclidean distance method is used to measure the similarity between Radix bupleuri samples, and the quality control chart method is applied to quantitatively describe their quality fluctuation.

Results
It is found that the samples from the same origin are relatively similar and mainly fluctuate within the control limit, but the fluctuation range is large, and it is impossible to distinguish the samples from different origins. The SVM algorithm can effectively eliminate the impact of intensity fluctuations and huge data dimensions by combining the normalization of MALDI-TOF MS data and the dimensionality reduction of principal components, and finally achieve efficient identification of the origin of Radix bupleuri, with an average recognition rate of 98.5%.

Conclusions
This newly established approach for identification of the geographic origin of Radix bupleuri has been realized, and it has the advantages of objectivity and intelligence, which can be used as a reference for other medical and food-related research.

Highlights
A new intelligent recognition method of medicinal material origin based on MALDI-TOF MS and SVM has been established.
Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma
Authors: Chow Ryan D , Long Jessica B , Hassan Sirad , Wheeler Stephanie B , Spees Lisa P , Leapman Michael S , Hurwitz Michael E , McManus Hannah D , Gross Cary P , Dinan Michaela A 
Published: May 2023

Abstract
Disparities in metastatic renal cell carcinoma (mRCC) outcomes persist in the era of oral anticancer agents (OAAs) and immunotherapies (IOs). We examined variation in the utilization of mRCC systemic therapies among US Medicare beneficiaries from 2015 to 2019. Logistic regression models evaluated the association between therapy receipt and demographic covariates including patient race, ethnicity, and sex. In total, 15 407 patients met study criteria. After multivariable adjustment, non-Hispanic Black race and ethnicity was associated with reduced IO (adjusted relative risk ratio [aRRR] = 0.76, 95% confidence interval [CI] = 0.61 to 0.95; P = .015) and OAA receipt (aRRR = 0.76, 95% CI = 0.64 to 0.90; P = .002) compared with non-Hispanic White race and ethnicity. Female sex was associated with reduced IO (aRRR = 0.73, 95% CI = 0.66 to 0.81; P &lt; .001) and OAA receipt (aRRR = 0.74, 95% CI = 0.68 to 0.81; P &lt; .001) compared with male sex. Thus, disparities by race, ethnicity, and sex were observed in mRCC systemic therapy utilization for Medicare beneficiaries from 2015 to 2019.
Colo-cutaneous fistula to the thigh secondary to acute sigmoid diverticulitis: a case report
Authors: Serpa Eduardo , Pacheco Felipe , Pindicura Sundarachalam , Marar Omar 
Published: May 2023

Abstract
Acute diverticulitis is one of the most common gastrointestinal illnesses that requires hospital admission. It has a broad range of presentations from uncomplicated disease to perforation and peritonitis that require emergent surgical exploration. Abscesses are one of the most common complications. We present a case of retroperitoneal abscess with extension to the antero-lateral upper thigh that was successfully treated with open Hartman’s procedure with drainage of psoas abscess and open drainage of thigh abscess.
Perceived and desired outcomes of urban coyote management methods
Authors: Buteau Rebecca J , Urbanek Rachael E , Dumas Christopher 
Published: May 2023

Abstract
Coyote (Canis latrans) management becomes increasingly necessary as the species' range expands, but some methods may be controversial in urban landscapes. Understanding why the public considers certain methods acceptable may help decrease conflict between residents and wildlife managers. We surveyed 4000 registered voters in New Hanover County, North Carolina, to evaluate attitudes toward three coyote management methods: no management, public education and trap/euthanasia. We used the expectancy-value model and multinomial logistic regression models to determine which public beliefs and desires regarding outcomes of each coyote management method predicted acceptance of each method. Attitudes of respondents who accepted a method differed from those who rejected the method. Positive attitudes toward no management were influenced by outcomes involving a natural death for coyotes and family, pet and personal safety. Positive attitudes toward public education were influenced by outcomes involving family safety, public participation, fewer coyotes and for coyotes to avoid an inhumane death. Positive attitudes toward trap/euthanasia were influenced by outcomes for coyotes avoiding an unnatural and inhumane death, pet safety and public participation. Understanding the public's beliefs and desires regarding coyote management methods will help wildlife managers tailor public education programs, resolve controversies regarding alternative management methods and improve future wildlife management decisions.
Metabolomics and molecular docking analysis of antibiotic exposure in Bifidobacterium adolescentis
Authors: Wang Qianyi , Guo Yue , Feng Shisui , Meng Mingwei , Huang Zheng , Qin Jinghua , Guo Bingjian , Zhang Chi , Nong Yunyuan , Feng Linlin , Song Hui , Liang Yonghong , Su Zhiheng 
Published: May 2023

Abstract
Bifidobacterium adolescentis is a probiotic. This research aimed to investigate the mechanism of antibiotics led to decrease in the number of B. adolescentis. The metabolomics approach was employed to explore the effects of amoxicillin on metabolism of B.adolescentis, while MTT assay and scanning electron microscopy were applied to analyse changes in viability and morphology of bacteria. Molecular docking was used to illuminate the mechanism by which amoxicillin acts on a complex molecular network. The results showed that increasing the concentration of amoxicillin led to a gradual decrease in the number of live bacteria. Untargeted metabolomics analysis identified 11 metabolites that change as a result of amoxicillin exposure. Many of these metabolites are involved in arginine and proline metabolism, glutathione metabolism, arginine biosynthesis, cysteine, and methionine metabolism, and tyrosine and phenylalanine metabolism. Molecular docking revealed that amoxicillin had a good binding effect on the proteins AGR1, ODC1, GPX1, GSH, MAT2A, and CBS. Overall, this research provides potential targets for screening probiotic regulatory factors and lays a theoretical foundation for the elucidation of its mechanisms.
The extended solar cycle and asymmetry of the large-scale magnetic field
Authors: Obridko V N , Shibalova A S , Sokoloff D D 
Published: May 2023

ABSTRACT
Traditionally, the solar activity cycle is thought as an interplay of the main dipole component of the solar poloidal magnetic field and the toroidal magnetic field. However, the real picture as presented in the extended solar-cycle models is much more complicated. Here, we develop the concept of the extended solar cycle clarifying what zonal harmonics are responsible for the equatorward and polarward propagating features in the surface activity tracers. We arrive at a conclusion that the zonal harmonics with l = 5 play a crucial role in separating the phenomena of both types, which are associated with the odd zonal harmonics. Another objective of our analysis is the role of even zonal harmonics, which prove to be rather associated with the north–south asymmetry of the solar activity than with its 11-yr solar periodicity.
Current proteomics methods applicable to dissecting the DNA damage response
Authors: Muralidharan Monita , Krogan Nevan J , Bouhaddou Mehdi , Kim Minkyu 
Published: May 2023

Abstract
The DNA damage response (DDR) entails reorganization of proteins and protein complexes involved in DNA repair. The coordinated regulation of these proteomic changes maintains genome stability. Traditionally, regulators and mediators of DDR have been investigated individually. However, recent advances in mass spectrometry (MS)-based proteomics enable us to globally quantify changes in protein abundance, post-translational modifications (PTMs), protein localization, and protein-protein interactions (PPIs) in cells. Furthermore, structural proteomics approaches, such as crosslinking MS (XL-MS), hydrogen/deuterium exchange MS (H/DX-MS), Native MS (nMS), provide large structural information of proteins and protein complexes, complementary to the data collected from conventional methods, and promote integrated structural modeling. In this review, we will overview the current cutting-edge functional and structural proteomics techniques that are being actively utilized and developed to help interrogate proteomic changes that regulate the DDR.
Characterization of cell-type specific circular RNAs associated with colorectal cancer metastasis
Authors: Zhao Sidi , Ly Amy , Mudd Jacqueline L , Rozycki Emily B , Webster Jace , Coonrod Emily , Othoum Ghofran , Luo Jingqin , Dang Ha X , Fields Ryan C , Maher Christopher A 
Published: May 2023

Abstract
Colorectal cancer (CRC) is the most common gastrointestinal malignancy and a leading cause of cancer deaths in the United States. More than half of CRC patients develop metastatic disease (mCRC) with an average 5-year survival rate of 13%. Circular RNAs (circRNAs) have recently emerged as important tumorigenesis regulators; however, their role in mCRC progression remains poorly characterized. Further, little is known about their cell-type specificity to elucidate their functions in the tumor microenvironment (TME). To address this, we performed total RNA sequencing (RNA-seq) on 30 matched normal, primary and metastatic samples from 14 mCRC patients. Additionally, five CRC cell lines were sequenced to construct a circRNA catalog in CRC. We detected 47 869 circRNAs, with 51% previously unannotated in CRC and 14% novel candidates when compared to existing circRNA databases. We identified 362 circRNAs differentially expressed in primary and/or metastatic tissues, termed circular RNAs associated with metastasis (CRAMS). We performed cell-type deconvolution using published single-cell RNA-seq datasets and applied a non-negative least squares statistical model to estimate cell-type specific circRNA expression. This predicted 667 circRNAs as exclusively expressed in a single cell type. Collectively, this serves as a valuable resource, TMECircDB (accessible at https://www.maherlab.com/tmecircdb-overview), for functional characterization of circRNAs in mCRC, specifically in the TME.
The prevalence and severity of fatigue in meningioma patients and its association with patient-, tumor- and treatment-related factors
Authors: Quach Kwong T , Dirven Linda , Vingerhoed Aliede M , de Bresser Jeroen , Dammers Ruben , Bos Eelke M , Moojen Wouter A , Peul Wilco C , Taphoorn Martin J B , Zamanipoor Najafabadi Amir H , van Furth Wouter R 
Published: May 2023

AbstractBackgroundFatigue is a commonly reported and severe symptom in primary brain tumor patients, but the exact occurrence in meningioma patients is unknown. This study aimed to determine the frequency and severity of fatigue in meningioma patients as well as associations between the level of fatigue and patient-, tumor-, and treatment-related factors.MethodsIn this multicenter cross-sectional study, meningioma patients completed questionnaires on fatigue (MFI-20), sleep (PSQI), anxiety and depression (HADS), tumor-related symptoms (MDASI-BT), and cognitive functioning (MOS-CFS). Multivariable regression models were used to evaluate the independent association between fatigue and each patient-, tumor-, and treatment-related factor separately, corrected for relevant confounders.ResultsBased on predetermined in- and exclusion criteria, 275 patients, on average 5.3 (SD = 2.0) year since diagnosis, were recruited. Most patients had undergone resection (92%). Meningioma patients reported higher scores on all fatigue subscales compared to normative data and 26% were classified as fatigued. Having experienced a complication due to resection (OR 3.6, 95% CI: 1.8–7.0), having received radiotherapy (OR 2.4, 95% CI: 1.2–4.8), a higher number of comorbidities (OR 1.6, 95% CI: 1.3–1.9) and lower educational level (low level as reference; high level OR 0.3, 95% CI: 0.2–0.7) were independently associated with more fatigue.ConclusionsFatigue is a frequent problem in meningioma patients even many years after treatment. Both patient- and treatment-related factors were determinants of fatigue, with the treatment-related factors being the most likely target for intervention in this patient population.
Lane-changing trajectory prediction based on multi-task learning
Authors: Meng Xianwei , Tang Jinjun , Yang Fang , Wang Zhe 
Published: May 2023

Abstract
As a complex driving behaviour, lane-changing (LC) behaviour has a great influence on traffic flow. Improper lane-changing behaviour often leads to traffic accidents. Numerous studies are currently being conducted to predict lane-change trajectories to minimize dangers. However, most of their models focus on how to optimize input variables without considering the interaction between output variables. This study proposes an LC trajectory prediction model based on a multi-task deep learning framework to improve driving safety. Concretely, in this work, the coupling effect of lateral and longitudinal movement is considered in the LC process. Trajectory changes in two directions will be modelled separately, and the information interaction is completed under the multi-task learning framework. In addition, the trajectory fragments are clustered by the driving features, and trajectory type recognition is added to the trajectory prediction framework as an auxiliary task. Finally, the prediction process of lateral and longitudinal trajectory and LC style is completed by long short-term memory (LSTM). The model training and testing are conducted with the data collected by the driving simulator, and the proposed method expresses better performance in LC trajectory prediction compared with several traditional models. The results of this study can enhance the trajectory prediction accuracy of advanced driving assistance systems (ADASs) and reduce the traffic accidents caused by lane changes.
Caregiver Satisfaction with Emergency Department Care for Pediatric Patients with Neurodevelopmental Disorders
Authors: Heyming Theodore W. , Knudsen-Robbins Chloe , Davis Konnor , Moreno Tatiana , Martin Sarah R. , Shelton Shelby K. , Ehwerhemuepha Louis , Kain Zeev N. 
Published: May 2023

Abstract:

Objective:
Children with neurodevelopmental disorders (NDDs) often encounter increased adversity when navigating the health care system. In this study, we explored the pediatric emergency department (PED) experience for patients with NDDs and their caregivers compared with that of patients without NDDs.

Methods:
Data for this study were obtained from National Research Corporation patient experience survey questionnaires and electronic medical record (EMR) data for patients presenting to a PED between May 2018 and September 2019. ED satisfaction was determined by the top-box approach; ED ratings of 9/10 or 10/10 were considered to reflect high ED satisfaction. Demographics, Emergency Severity Index, ED length of stay, time from arrival to triage, time to provider assessment, and diagnoses were extracted from the EMR. Patients with NDDs were identified based on International Classification of Diseases, Tenth Revision codes; patients with intellectual disabilities, pervasive and specific developmental disorders, or attention-deficit/hyperactivity disorders were included in the NDD cohort. One-to-one propensity score matching between patients with and without NDDs was performed, and a multivariable logistic regression model was built on the matched cohort.

Results:
Patients with NDDs represented over 7% of survey respondents. Matching was successful for 1162 patients with NDDs (99.5%), resulting in a matched cohort sample size of 2324. Caregivers of patients with NDDs had 25% lower odds of reporting high ED satisfaction (95% confidence interval [CI], 0.62–0.91, p = 0.004).

Conclusion:
Caregivers of patients with NDDs make up a significant proportion of survey respondents and are more likely to rate the ED poorly than caregivers of patients without NDDs. This suggests an opportunity for targeted interventions in this population to improve patient care and experience.
Patient Outcomes following Septoplasty in Patients with Attention-deficit/Hyperactivity Disorder
Authors: Garoosi Kassra B. , Hale Elijah W. , Getz Anne E. , Kaoutzanis Christodoulos 
Published: May 2023

Summary:
Recent research has indicated that daytime manifestations of sleep-disordered breathing, frequently caused by deviated septum, can mimic many characteristic symptoms of attention-deficit/hyperactivity disorder (ADHD) and could indicate intermittent hypoxia or hypercarbia as factors in the development of ADHD. To investigate the differences in outcomes following septoplasty between patients with ADHD and deviated septum, we used a retrospective cohort design to compare outcomes in patients diagnosed with deviated septa between June 1, 2002 and June 1, 2022. We then separated these patients into four total groups based on the presence or absence of ADHD diagnosis and the presence or absence of septoplasty. After matching cohorts to create insignificant differences in age, sex, and race, we analyzed various outcomes associated with ADHD, such as conduct disorders, anxiety disorders, fractures, and substance abuse disorders. Septoplasty reduces the risk for nearly all outcomes in patients with deviated septum, with statistically significant results present in 11 of 15 outcomes in both ADHD and non-ADHD groups. The effect of septoplasty was up to 10 times greater for the ADHD cohort. Patients with ADHD who receive septoplasty display a plethora of beneficial effects, with significantly reduced risk of common sequelae such as depression, obsessive-compulsive disorder, anxiety, and addictive disorders. The difference in outcomes indicates future prospective studies into outcomes of septoplasty in patients with ADHD.
Frontofacial Features of Unilateral Lambdoid Craniosynostosis: A Multicenter Assessment
Authors: Lee Jonathan , Naran Sanjay , Mazzaferro Daniel , Wes Ari , Anstadt Erin E. , Taylor Jesse , Goldstein Jesse , Bartlett Scott , Losee Joseph 
Published: May 2023

Background:
Unilateral lambdoid craniosynostosis is differentiated from deformational plagiocephaly primarily by assessing the cranium from posterior and bird’s-eye views. Findings include posterior displacement of the ipsilateral ear, ipsilateral occipitomastoid bossing, ipsilateral occipitoparietal flattening, contralateral parietal bossing, and contralateral frontal bossing. Diagnosis based off facial morphology may be an easier approach because the face is less obstructed by hair and head-coverings, and can easily be assessed when supine. However, frontofacial characteristics of unilateral lambdoid craniosynostosis are not well described.

Methods:
A retrospective cohort review of patients with isolated, unilateral lambdoid craniosynostosis from the Children’s Hospital of Pittsburgh and the Children’s Hospital of Philadelphia was performed. Preoperative frontal and profile photographs were reviewed for salient characteristics.

Results:
Nineteen patients met inclusion criteria. Eleven patients had left lambdoid craniosynostosis, and eight had right lambdoid craniosynostosis. All patients were nonsyndromic. Patients demonstrated contralateral parietal bossing and greater visibility of the ipsilateral ear. Contralateral frontal bossing was mild. The orbits were tall and turricephaly was present in varying severity. Facial scoliosis as a C-shaped deformity was present in varying severity. The nasal root and chin pointed to the contralateral side.

Conclusions:
The combination of greater visibility of the ipsilateral ear, contralateral parietal bossing, and C-shaped convex ipsilateral facial scoliosis are hallmark frontofacial features of unilateral lambdoid craniosynostosis. Although the ipsilateral ear is more posterior, the greater visibility may be attributed to lateral displacement from the mastoid bulge. Evaluation of long-term postoperative results is needed to assess if this pathognomonic facial morphology is corrected following posterior vault reconstruction.
Effectiveness of HCC surveillance programs using multitarget blood test: A modeling study
Authors: Chhatwal Jagpreet , Samur Sumeyye , Yang Ju Dong , Roberts Lewis R. , Nguyen Mindie H. , Ozbay A. Burak , Ayer Turgay , Parikh Neehar D. , Singal Amit G. 
Published: May 2023

Background:
The effectiveness of ultrasound-based surveillance for HCC in patients with cirrhosis is limited by suboptimal sensitivity for early tumor detection and poor adherence. Emerging blood-based biomarkers have been proposed as an alternative surveillance strategy. We aimed to evaluate the comparative effectiveness of a multitarget HCC blood test (mt-HBT)—with and without improved adherence—against ultrasound-based HCC surveillance.

Methods:
We developed a Markov-based mathematical model that simulated a virtual trial in patients with compensated cirrhosis comparing potential surveillance strategies: biannual surveillance using ultrasound, ultrasound plus AFP, and mt-HBT with or without improved adherence (+10% increase). We used published data to inform underlying liver disease progression rates, HCC tumor growth patterns, performance characteristics of surveillance modalities, and efficacy of treatments. Primary outcomes of interest were the number of early-stage HCCs detected and life years gained.

Results:
Per 100,000 patients with cirrhosis, mt-HBT detected 1680 more early-stage HCCs than ultrasound alone and 350 more early-stage HCCs than ultrasound + AFP, yielding an additional 5720 and 1000 life years, respectively. mt-HBT with improved adherence detected 2200 more early-stage HCCs than ultrasound and 880 more early-stage HCCs than ultrasound + AFP, yielding an additional 8140 and 3420 life years, respectively. The number of screening tests needed to detect one HCC case was 139 with ultrasound, 122 with ultrasound + AFP, 119 with mt-HBT, and 124 with mt-HBT with improved adherence.

Conclusions:
mt-HBT is a promising alternative to ultrasound-based HCC surveillance, particularly given anticipated improved adherence with blood-based biomarkers could increase HCC surveillance effectiveness.