bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience
Authors: Guercio Brendan J. , Sarfaty Michal , Teo Min Yuen , Ratna Neha , Duzgol Cihan , Funt Samuel A. , Lee Chung-Han , Aggen David H. , Regazzi Ashley M. , Chen Ziyu , Lattanzi Michael , Al-Ahmadie Hikmat A. , Brannon A. Rose , Shah Ronak , Chu Carissa , Lenis Andrew T. , Pietzak Eugene , Bochner Bernard H. , Berger Michael F. , Solit David B. , Rosenberg Jonathan E. , Bajorin Dean F. , Iyer Gopa 
Published: September 2023

Abstract

Purpose:
Erdafitinib is the only FDA-approved targeted therapy for FGFR2/3-altered metastatic urothelial cancer. We characterized the genetic landscape of FGFR-altered urothelial carcinoma and real-world clinical outcomes with erdafitinib, including on-treatment genomic evolution.

Experimental Design:
Prospectively collected clinical data were integrated with institutional genomic data to define the landscape of FGFR2/3-altered urothelial carcinoma. To identify mechanisms of erdafitinib resistance, a subset of patients underwent prospective cell-free (cf) DNA assessment.

Results:
FGFR3 alterations predictive of erdafitinib sensitivity were identified in 39% (199/504) of patients with non-muscle invasive, 14% (75/526) with muscle-invasive, 43% (81/187) with localized upper tract, and 26% (59/228) with metastatic specimens. One patient had a potentially sensitizing FGFR2 fusion. Among 27 FGFR3-altered cases with a primary tumor and metachronous metastasis, 7 paired specimens (26%) displayed discordant FGFR3 status. Erdafitinib achieved a response rate of 40% but median progression-free and overall survival of only 2.8 and 6.6 months, respectively (n = 32). Dose reductions (38%, 12/32) and interruptions (50%, 16/32) were common. Putative resistance mutations detected in cfDNA involved TP53 (n = 5), AKT1 (n = 1), and second-site FGFR3 mutations (n = 2).

Conclusions:
FGFR3 mutations are common in urothelial carcinoma, whereas FGFR2 alterations are rare. Discordance of FGFR3 mutational status between primary and metastatic tumors occurs frequently and raises concern over sequencing archival primary tumors to guide patient selection for erdafitinib therapy. Erdafitinib responses were typically brief and dosing was limited by toxicity. FGFR3, AKT1, and TP53 mutations detected in cfDNA represent putative mechanisms of acquired erdafitinib resistance.
Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO Inhibition
Authors: Syed-Abdul Majid Mufaqam , Tian Lili , Lewis Gary F. 
Published: September 2023

BACKGROUND:
The objective of this study was to investigate whether apoC3 (apolipoprotein C3) inhibition with an antisense oligonucleotide (ASO) modulates intestinal triglyceride secretion.

METHODS:
Sprague-Dawley rats were treated with subcutaneous injections of apoC3 ASO 25 mg/kg twice weekly or inactive ASO for 4 weeks before the assessment of lymph flow, triglyceride and apoB48 (apolipoprotein B48) appearance in the lymph. Rats were surgically implanted with catheters in the mesenteric lymph duct and duodenum. Following an overnight fast, an intraduodenal lipid bolus (1.5-mL intralipid) was administered. Lymph fluid was collected for the following 4 hours to compare effects on lymph flow, lymph triglyceride and apoB48 concentration, and secretion. To assess suppression of apoC3 expression and protein abundance by apoC3 ASO compared with inactive ASO (placebo), intestinal and hepatic tissues were collected from a subset of animals before (fasting) and after an enteral lipid bolus (post-lipid).

RESULTS:

ApoC3 ASO significantly reduced apoC3 mRNA expression in the liver compared with inactive ASO (fasting: 42%,
P
=0.0048; post-lipid: 66%,
P
<0.001) and in the duodenum (fasting: 29%,
P
=0.0424; post-lipid: 53%,
P
=0.0120). As expected, plasma triglyceride also decreased significantly (fasting: 74%,
P
<0.001; post-lipid: 33%,
P
=0.0276). Lymph flow and cumulative lymph volume remained unchanged following apoC3 ASO therapy; however, lymph triglyceride, but not apoB48 output, increased by 38% (ANOVA,
P
<0.001). Last, no changes were observed in stool triglyceride, intestinal fat (quantified via oil red O staining), and expression of mRNAs involved in triglyceride synthesis, lipid droplet formation, and chylomicron transport and secretion.

CONCLUSIONS:
Despite the marked reduction in plasma triglyceride concentration that occurs with apoC3 ASO inhibition, intestinal triglyceride output surprisingly increased rather than decreased. These data demonstrate that the reduction of intestinal triglyceride output does not contribute to the potent plasma triglyceride-lowering observed with this novel therapy for hypertriglyceridemia. Further studies are required to explore the mechanism of this intestinal effect.
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
Authors: Lee Samuel K. , Malik Rida A. , Zhou Ji , Wang Wei , Gross Peter L. , Weitz Jeffrey I. , Ramachandran Rithwik , Trigatti Bernardo L. 
Published: September 2023

BACKGROUND:
SR-B1 (scavenger receptor class B type 1)/LDLR (low-density lipoprotein receptor) double knockout mice fed a high-fat, high-cholesterol diet containing cholate exhibit coronary artery disease characterized by occlusive coronary artery atherosclerosis, platelet accumulation in coronary arteries, and myocardial fibrosis. Platelets are involved in atherosclerosis development, and PAR (protease-activated receptor) 4 has a prominent role in platelet function in mice. However, the role of PAR4 on coronary artery disease in mice has not been tested.

METHODS:
We tested the effects of a PAR4 inhibitory pepducin (RAG8) on diet-induced aortic sinus and coronary artery atherosclerosis, platelet accumulation in atherosclerotic coronary arteries, and myocardial fibrosis in SR-B1/LDLR double knockout mice. SR-B1/LDLR double knockout mice were fed a high-fat, high-cholesterol diet containing cholate and injected daily with 20 mg/kg of either the RAG8 pepducin or a control reverse-sequence pepducin (SRQ8) for 20 days.

RESULTS:
Platelets from the RAG8-treated mice exhibited reduced thrombin and PAR4 agonist peptide–mediated activation compared with those from control SRQ8-treated mice when tested ex vivo. Although aortic sinus atherosclerosis levels did not differ, RAG8-treated mice exhibited reduced coronary artery atherosclerosis, reduced platelet accumulation in atherosclerotic coronary arteries, and reduced myocardial fibrosis. These protective effects were not accompanied by changes in circulating lipids, inflammatory cytokines, or immune cells. However, RAG8-treated mice exhibited reduced VCAM-1 (vascular cell adhesion molecule 1) protein levels in nonatherosclerotic coronary artery cross sections and reduced leukocyte accumulation in atherosclerotic coronary artery cross sections compared with those from SRQ8-treated mice.

CONCLUSIONS:
The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.
Changes in Cardiovascular Spending, Care Utilization, and Clinical Outcomes Associated With Participation in Bundled Payments for Care Improvement – Advanced
Authors: Shashikumar Sukruth A. , Zheng Jie , Orav E. John , Epstein Arnold M. , Joynt Maddox Karen E. 
Published: September 2023

BACKGROUND:
Bundled Payments for Care Improvement – Advanced (BPCI-A) is a Medicare initiative that aims to incentivize reductions in spending for episodes of care that start with a hospitalization and end 90 days after discharge. Cardiovascular disease, an important driver of Medicare spending, is one of the areas of focus BPCI-A. It is unknown whether BPCI-A is associated with spending reductions or quality improvements for the 3 cardiovascular medical events or 5 cardiovascular procedures in the model.

METHODS:
In this retrospective cohort study, we conducted difference-in-differences analyses using Medicare claims for patients discharged between January 1, 2017, and September 30, 2019, to assess differences between BPCI-A hospitals and matched nonparticipating control hospitals. Our primary outcomes were the differential changes in spending, before versus after implementation of BPCI-A, for cardiac medical and procedural conditions at BPCI-A hospitals compared with controls. Secondary outcomes included changes in patient complexity, care utilization, healthy days at home, readmissions, and mortality.

RESULTS:

Baseline spending for cardiac medical episodes at BPCI-A hospitals was $25 606. The differential change in spending for cardiac medical episodes at BPCI-A versus control hospitals was $16 (95% CI, −$228 to $261;
P
=0.90). Baseline spending for cardiac procedural episodes at BPCI-A hospitals was $37 961. The differential change in spending for cardiac procedural episodes was $171 (95% CI, −$429 to $772;
P
=0.58). There were minimal differential changes in physicians’ care patterns such as the complexity of treated patients or in their care utilization. At BPCI-A versus control hospitals, there were no significant differential changes in rates of 90-day readmissions (differential change, 0.27% [95% CI, −0.25% to 0.80%] for medical episodes; differential change, 0.31% [95% CI, −0.98% to 1.60%] for procedural episodes) or mortality (differential change, −0.14% [95% CI, −0.50% to 0.23%] for medical episodes; differential change, −0.36% [95% CI, −1.25% to 0.54%] for procedural episodes).

CONCLUSIONS:
Participation in BPCI-A was not associated with spending reductions, changes in care utilization, or quality improvements for the cardiovascular medical events or procedures offered in the model.
Pierre Janet’s Secret Garden, or the Botanical Collection of a Psychopathologist
Authors: Serina Florent 
Published: September 2023

Abstract
Pierre Janet, the French philosopher, psychotherapist, and doctor (1859–1947), has often been presented as one of the central figures in contemporary clinical psychology, whose practices and ideas are said to have anticipated those of Sigmund Freud, before becoming a fierce critic of psychoanalysis. What is less well known, however, is that he was also an experienced botanist. The recent discovery of his personal herbarium, which was long thought to be lost, leads historians to address a curious paradox. Unlike his professional papers, of which only a fraction remains, his entire collection built up over 70 years of passionate collecting has been preserved. Thus although the world-famous clinician, bound to medical secrecy, still resists historical exposition, the hitherto unknown amateur naturalist appears in the full light of day. Even though Janet was careful not to hastily amalgamate the study of human behaviour to that of plants, detailed examination of his abundant written work shows that these two disciplines could overlap on occasions.
Producing Authenticity, Difference and Extremism
Authors: van den Brandt Nella , van den Berg Mariecke , Meijer Béracha 
Published: September 2023

Abstract
In this article, we explore the framing of religious converts by Dutch and Flemish newspapers in the period 1991–2017. We focus on the differences and commonalities in ways of talking about religious conversions to Christianity and Islam. Our approach is to probe the ‘figure’ of the convert: How is the religious convert framed and understood? We present a typology of figures of the religious convert emerging from our material, including the ‘authentic seeker’, the ‘exemplary believer’, the ‘cultural other’, the ‘victim’, the ‘opportunist’ and the ‘extremist’. This approach allows us to explore how newspapers promote particular notions of conversion, and to show that the framing of religious converts is mediated by religion, gender, race and citizenship.
“Assalamu ʿAlaykum, Can We Add This Sister?”
Authors: ter Laan Nina 
Published: September 2023

Abstract
This article examines the use of a WhatsApp chat group by Dutch and Belgian Muslim women (born or converted), who are considering or made hijra (religiously inspired migration to a Muslim country) to Morocco. I argue that WhatsApp plays a crucial role in facilitating and narrating these women’s migration by providing a support network and shaping a gendered sense of community and religious belonging. Drawing on theories of religion and gender, migration, and digital media, I conceptualize WhatsApp in the context of hijra to Morocco as a social practice of homemaking that helps alleviate the precarious conditions these women find themselves in. This article also illustrates the complex entanglement of offline and online realities by highlighting how my interlocutors’ interactions in this WhatsApp group foster a trans-local Muslim ‘sisterhood,’ that informs their offline practices and experiences of hijra to Morocco.
Between Symbolic Distancing and Following Desires
Authors: Rau Vanessa 
Published: September 2023

Abstract
Over the past decades, Judaism and Jewishness have been subject to transformation and more fluid boundaries. This article looks at women’s conversions to Judaism in Germany. Analyzing differing biographical trajectories, the article shows how individuals negotiate their desire to become Jewish, which is often closely related to an experience in Israel and a Jewish partner. Arguing that the context makes the conversion, I show how desires and negotiations are deeply entangled with the socio-historical context of German society as well as with the erotic and sexuality. I demonstrate how becoming Jewish presents a way of symbolically distancing oneself from biographical experiences of difference, which are negotiated in and through the conversion. As these conversions are not uncontested, I also show how becoming part of Jewish socialities evokes a negotiation of one’s positionality at the intersection of gender and religion.
The Macro- and Microphysical Response Characteristics of the Multicell Hailstorm Hail-Suppression Operation: Case Study
Authors: Lu Yuan , Zhou Yunjun , Zou Shuping , Yang Zhe , Zeng Yong 
Published: September 2023

Abstract
This study analyzed the macro- and microphysical response characteristics of a typical multicell hailstorm after seeding on 27 April 2019 in Weining, China, using X-band dual-polarization radar (YLD1-D) data. An improved X-pol hydrometeor identification algorithm was employed for hydrometeor identification. According to the diffusion of the seeding agents, the seeded hailstorm was graded into three study regions, and the evolution of the seeded hailstorm was divided into four periods. The response characteristics of the seeded hailstorm in each region and period were compared and analyzed. The results show that 1) macroscopically, the decrease in the reflectivity and the height of strong echo mainly occurred in the seeded period, whereas the decrease in the echo top and the height of the storm was mainly in the postseeded period; the echo height variation of the unseeded hailstorm is obviously different from that of the seeded hailstorm; and 2) from the microscopic perspective, the decrease in low-density graupel and supercooled water and the increase in ice crystals and aggregates in the seeded region mainly occurred in the seeded period, which was consistent with the time required for the “benefit competition” after the silver iodide completed nucleation. When compared with the seeded region, the hydrometeors in the unseeded region had an opposite trend (or an in-phase trend with an obviously lower changing rate), which further indicated the impact of the artificial ice nuclei on microphysical processes in the seeded region. For hailstorms with a high content of supercooled droplets and graupel, the key mechanisms of hail suppression are “cloud water glaciation,” “beneficial competition,” and “early rainout.”
Synoptic and Mesoscale Aspects of Exceptional Fire Weather during the New Year Period 2019–20 in Southeastern New South Wales, Australia
Authors: Fox-Hughes Paul 
Published: September 2023

Abstract
Extreme fire weather and fire behavior occurred during the New Year’s Eve period 30–31 December 2019 in southeast New South Wales, Australia. Fire progressed rapidly during the late evening and early morning periods, and significant extreme pyrocumulonimbus behavior developed, sometimes repeatedly in the same area. This occurred within a broader context of an unprecedented fire season in eastern Australia. Several aspects of the synoptic and mesoscale meteorology are examined, to identify contributions to fire behavior during this period. The passage of a cold front through the region was a key factor in the event, but other processes contributed to the severity of fire weather. Additional important features during this period included the movement of a negatively tilted upper-tropospheric trough, the interaction of the front with topography, and the occurrence of low-level overnight jets and of horizontal boundary layer rolls in the vicinity of the fireground.

Significance Statement
Wildfires and the weather that promotes their ignition and spread are a threat to communities and natural values globally, even in fire-adapted landscapes such as the western United States and Australia. In particular, savanna in the north of Australia regularly burns during the dry season while forest and grassland in the south burn episodically, mostly during the summer. Here, we examine the weather associated with destructive fires that occurred in southeast New South Wales, Australia, in late 2019. Weather and climate factors at several scales interacted to contribute to fire activity that was unusually dangerous. For meteorologists and emergency managers, case studies such as this are valuable to highlight conditions that may lead to future similar events. This case study also identified areas where improvements in fire weather service can be made, including the incorporation of more detailed weather information into models of fire behavior.
Mental health and current issues of migrant workers in Japan: A cross-sectional study of Vietnamese workers
Authors: Uezato Akihito , Sakamoto Kohei , Miura Mieko , Futami Akane , Nakajima Toshihiko , Quy Pham Nguyen , Jeong Soi , Tomita Shigeru , Saito Yoshihisa , Fukuda Yui , Yoshizawa Nonoka , Taguchi Atsuko 
Published: September 2023

Background: Over the past 5 years, the number of Vietnamese migrant workers in Japan has grown rapidly to become the largest group of migrant workers in the country. They hold various statuses of residence and are subjected to multifactorial stressors. Aims: The current study’s aim is to investigate the association between psychological distress experienced by Vietnamese workers and their work environment. Another aim is to discuss issues involving migrant workers by comparing the characteristics of workers in the major statuses of residence. Methods: The study applied a cross-sectional design, and included a nationwide self-administered online questionnaire that was conducted in Vietnamese in 2022. The questionnaire included the Kessler Psychological Distress Scale (K10), workplace interpersonal factors as well as factors related to work and health. A multiple logistic regression analysis was conducted to investigate factors associated with psychological distress. Results: Of 933 Vietnamese workers, 37% were grouped as distressed under the K10 cutoff. Fewer opportunities to speak with Japanese co-workers, lower welfare and workload ratings, and the visa statuses including ‘Technical Intern Training’ were significantly associated with psychological distress. Unexpectedly, those in ‘Engineer/Specialist in Humanities/International Services (ESI)’ category who are deemed to hold better conditions demonstrated the highest amounts of distress. Conclusion: Outside of unsatisfactory working environments, differing situations depending on status of residence could produce various sources of distress. The difficult aspects of Japan’s distinct culture seem to contribute to their distress, especially for those who have more interactions with Japanese co-workers. A push for a multicultural society, where migrant workers can pursue proactive life designs of their own choosing, is warranted.
Favorable Patient-Reported, Clinical, and Functional Outcomes 2 Years After ACL Repair and InternalBrace Augmentation Compared With ACL Reconstruction and Healthy Controls
Authors: Müller Sebastian , Bühl Linda , Nüesch Corina , Pagenstert Geert , Mündermann Annegret , Egloff Christian 
Published: September 2023

Background: Recently, interest in anterior cruciate ligament (ACL) preservation and repair after proximal ACL tears has been resurrected. Although good clinical outcomes have been reported in the literature with adequate patient selection, to date detailed scientific evidence for the functional benefit of primary ACL repair with ligament augmentation is scarce. Purpose: To compare patient-reported, clinical, and functional outcomes in patients 2 years after ACL repair and InternalBrace augmentation (ACL-IB) with age- and sex-matched patients 2 years after ACL reconstruction (ACL-R) and with matched healthy controls. Study Design: Cohort study; Level of evidence, 3. Methods: In total, 29 patients 2 years after ACL-IB, 27 sex- and age- matched patients 2 years after ACL-R (hamstring autografts), and 29 matched healthy controls were included. Patient-reported outcomes were assessed using the International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score, EQ-5D-5L, Tegner Activity Scale, and Anterior Cruciate Ligament Return to Sports after Injury scale. Surgery time was recorded. For clinical outcomes, range of motion and thigh and shank circumference were measured, and passive anterior translation was determined using the Rolimeter. Isokinetic muscle strength was measured using a Biodex dynamometer. The limb symmetry index (operated/contralateral or nondominant/dominant × 100), side-to-side differences (operated – contralateral, nondominant – dominant), and hamstring-quadriceps ratios were calculated for functional parameters. Failure and reoperation rates were not compared. Results: Two years after surgery, patients treated with ACL-IB showed good to excellent patient-reported outcomes comparable with those of patients after ACL-R. Surgery time, including concomitant surgeries, was significantly shorter in the ACL-IB group (mean, 81 minutes) compared with the ACL-R group (mean, 97 minutes) ( P = .024). Isokinetic muscle strength was comparable between patient groups without significant differences in extensor and flexor strength or in hamstring-quadriceps ratios. Conclusion: These results suggest that ACL-IB achieves comparable patient-reported, clinical, and functional outcomes with ACL-R at 2 years postoperatively and, after careful patient selection, should be considered as a valuable early treatment alternative for proximal ACL tears. Registration: NCT04429165 (ClinicalTrials.gov identifier).