bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work
Authors: Muirhead Russell 
Published: August 2023

AbstractWork was once at the center of modern social and political theory; in recent decades it has been relegated to the margins. Work became a central political and social concern in the wake of the Protestant Reformation, which affirmed the moral status of ordinary life; this centrality was later amplified by the potent critique of labor under capitalism issued by Marx and later Marxists in the nineteenth and twentieth centuries. The more recent marginalization of work is a reflection of the antiperfectionist turn in contemporary political theory. This is likely to be a passing phenomenon: the importance of work in democratic culture and human experience has already led political theorists to a re‐engagement with work and its discontents.
Pd‐Catalyzed Decarboxylative Cross‐Coupling of N‐Aryl Anthranilic Acids to Access Carbazoles: Gram Scale Total Synthesis of Anti‐ Cancer Drug Ellipticine
Authors: Nadella Lavanya , Dadinaboyina S. Babu , Kumar Perla Bharath , Kanaparthy Suneel , Gaddam Vikram 
Published: August 2023

AbstractAn efficient and scalable Pd‐catalyzed decarboxylative cross‐coupling strategy for the synthesis of carbazoles has been developed by using N‐aryl anthranilic acids. By employing a well‐designed catalytic system, this protocol access diverse carbazole derivatives via a C−C bond‐formation in one‐pot. The substituted carbazoles were obtained in good to excellent yields with high functional‐group tolerance. We have also demonstrated the gram‐scale synthesis of the anti‐cancer drug Ellipticine by utilizing this methodology. This concise and scalable total synthesis of ellipticine exemplifies the efficiency of our methodology in producing this significant anti‐cancer compound.
Elastic Polymer Coated Nanoparticles with Fast Clearance for 19F MR Imaging
Authors: Konishi Yuki , Minoshima Masafumi , Fujihara Kohei , Uchihashi Takayuki , Kikuchi Kazuya 
Published: August 2023

Abstract19F magnetic resonance imaging (MRI) is a powerful molecular imaging technique that enables high‐resolution imaging of deep tissues without background signal interference. However, the use of nanoparticles (NPs) as 19F MRI probes has been limited by the immediate trapping and accumulation of stiff NPs, typically of around 100 nm in size, in the mononuclear phagocyte system, particularly in the liver. To address this issue, elastic nanomaterials have emerged as promising candidates for improving delivery efficacy in vivo. Nevertheless, the impact of elasticity on NP elimination has remained unclear due to the lack of suitable probes for real‐time and long‐term monitoring. In this study, we present the development of perfluorocarbon‐encapsulated polymer NPs as a novel 19F MRI contrast agent, with the aim of suppressing long‐term accumulation. The polymer NPs have high elasticity and exhibit robust sensitivity in 19F MRI imaging. Importantly, our 19F MRI data demonstrate a gradual decline in the signal intensity of the polymer NPs after administration, which contrasts starkly with the behavior observed for stiff silica NPs. This innovative polymer‐coated NP system represents a groundbreaking nanomaterial that successfully overcomes the challenges associated with long‐term accumulation, while enabling tracking of biodistribution over extended periods.
Enzymatic Benzofuranoindoline Formation in the Biosynthesis of the Strained Bridgehead Bicyclic Dipeptide (+)‐Azonazine A
Authors: Liu Mengting , Ohashi Masao , Zhou Qingyang , Sanders Jacob N. , McCauley Erin P. , Crews Phillip , Houk K. N. , Tang Yi 
Published: August 2023

AbstractWe uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)‐azonazine A from marine‐derived Aspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo‐(l‐Trp‐N‐methyl‐l‐Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole‐substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.
Design of an Oxygen‐Tolerant Photo‐RAFT System for Protein‐Polymer Conjugation Achieving High Bioactivity
Authors: Zhang Tong , Wu Zilong , Ng Gervase , Boyer Cyrille 
Published: August 2023

AbstractProtein‐polymer conjugates have significant potential in pharmaceutical and biomedical applications. To enable their widespread use, robust conjugation techniques are crucial. This study introduces a photo‐initiated reversible addition‐fragmentation chain‐transfer (Photo‐RAFT) polymerization system that exhibits excellent oxygen tolerance. This system allows for the synthesis of protein‐polymer conjugates with high bioactivity under mild and aerobic conditions. Three photocatalytic systems utilizing Eosin Y (EY) as the photocatalyst with two different cocatalysts (ascorbic acid and triethanolamine) were investigated, each generating distinct reactive oxygen species (ROS) such as singlet oxygen, superoxide, hydrogen peroxide, and hydroxyl radicals. The impact of these ROS on three model proteins (lysozyme, albumin, and myoglobin) was evaluated, demonstrating varying bioactivities based on the ROS produced. The EY/TEOA system was identified as the optimal photo‐RAFT initiating system, enabling the preparation of protein‐polymer conjugates under aerobic conditions while maintaining high protein enzymatic activity. To showcase the potential of this approach, lysozyme‐poly(dimethylaminoethyl acrylate) conjugates were successfully prepared and exhibited enhanced antimicrobial property against Gram‐positive and Gram‐negative bacteria.
c‐FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma
Authors: Osada Naoki , Kikuchi Jiro , Iha Hidekatsu , Yasui Hiroshi , Ikeda Sho , Takahashi Naoto , Furukawa Yusuke 
Published: August 2023

AbstractBackgroundThe immunomodulatory drug lenalidomide, which is now widely used for the treatment of multiple myeloma (MM), exerts pharmacological action through the ubiquitin‐dependent degradation of IKZF1 and subsequent down‐regulation of interferon regulatory factor 4 (IRF4), a critical factor for the survival of MM cells. IKZF1 acts principally as a tumour suppressor via transcriptional repression of oncogenes in normal lymphoid lineages. In contrast, IKZF1 activates IRF4 and other oncogenes in MM cells, suggesting the involvement of unknown co‐factors in switching the IKZF1 complex from a transcriptional repressor to an activator. The transactivating components of the IKZF1 complex might promote lenalidomide resistance by residing on regulatory regions of the IRF4 gene to maintain its transcription after IKZF1 degradation.MethodsTo identify unknown components of the IKZF1 complex, we analyzed the genome‐wide binding of IKZF1 in MM cells using chromatin immunoprecipitation‐sequencing (ChIP‐seq) and screened for the co‐occupancy of IKZF1 with other DNA‐binding factors on the myeloma genome using the ChIP‐Atlas platform.ResultsWe found that c‐FOS, a member of the activator protein‐1 (AP‐1) family, is an integral component of the IKZF1 complex and is primarily responsible for the activator function of the complex in MM cells. The genome‐wide screening revealed the co‐occupancy of c‐FOS with IKZF1 on the regulatory regions of IKZF1‐target genes, including IRF4 and SLAMF7, in MM cells but not normal bone marrow progenitors, pre‐B cells or mature T‐lymphocytes. c‐FOS and IKZF1 bound to the same consensus sequence as the IKZF1 complex through direct protein‐protein interactions. The complex also includes c‐JUN and IKZF3 but not IRF4. Treatment of MM cells with short‐hairpin RNA against FOS or a selective AP‐1 inhibitor significantly enhanced the anti‐MM activity of lenalidomide in vitro and in two murine MM models. Furthermore, an AP‐1 inhibitor mitigated the lenalidomide resistance of MM cells.ConclusionsC‐FOS determines lenalidomide sensitivity and mediates drug resistance in MM cells as a co‐factor of IKZF1 and thus, could be a novel therapeutic target for further improvement of the prognosis of MM patients.
Linkage between surface energy balance non‐closure and horizontal asymmetric turbulent transport
Authors: Lan Changxing , Wang Baomin , Li Lei , Fang Renzhi , Wang Ye , Zhang Zhijie , Zheng Dan , Zheng Baofeng 
Published: August 2023

AbstractA number of studies have reported that the traditional eddy covariance (EC) method generally underestimated vertical turbulent fluxes, leading to an outstanding non‐closure problem of the surface energy balance (SEB). Although it is recognized that the enlarged surface energy imbalance frequently coincides with the increasing wind shear, the role of large eddies in affecting the SEB remains unclear. On analyzing data collected by an EC array, considerable horizontal inhomogeneity of kinematic heat flux is observed. The results show that the combined EC method that incorporates the spatial flux contribution increases the kinematic heat flux by 21% relative to the traditional EC method, improving the SEB closure. Additionally, spectral analysis indicates that large eddies with scales ranging from 0.0005 to 0.01 (in the normalized frequency) mainly account for the horizontal inhomogeneity of kinematic heat flux. Under unstable conditions, this process is operating upon large eddies characterized by enlarged asymmetric turbulent flux transport. With enhanced wind shear, the increment of flux contribution associated with sweeps and ejections becomes disproportionate, contributing to the horizontal inhomogeneity of kinematic heat flux, and thus may explain the increased SEB non‐closure.
Fermion hierarchies in SU(5) grand unification from $$ {\Gamma}_6^{\prime } $$ modular flavor symmetry
Authors: Abe Yoshihiko , Higaki Tetsutaro , Kawamura Junichiro , Kobayashi Tatsuo 
Published: August 2023

Abstract
We construct an SU(5) grand unified model in which the hierarchies of the quark and lepton masses and mixing are explained by the $$ {\Gamma}_6^{\prime } $$

Γ
6
′

modular flavor symmetry. The hierarchies are realized by the Froggatt-Nielsen-like mechanism due to the residual $$ {Z}_6^T $$

Z
6
T

symmetry, approximately unbroken at τ ~ i∞. We argue that the $$ {\Gamma}_6^{\left({}^{\prime}\right)} $$

Γ
6

′

symmetry is the minimal possibility to realize the up-type quark mass hierarchies, since the Yukawa matrix is symmetric. We find a combination of the representations and modular weights and then show numerical values of (1) coefficients for the realistic fermion hierarchies.
Krylov complexity in large q and double-scaled SYK model
Authors: Bhattacharjee Budhaditya , Nandy Pratik , Pathak Tanay 
Published: August 2023

Abstract
Considering the large q expansion of the Sachdev-Ye-Kitaev (SYK) model in the two-stage limit, we compute the Lanczos coefficients, Krylov complexity, and the higher Krylov cumulants in subleading order, along with the t/q effects. The Krylov complexity naturally describes the “size” of the distribution while the higher cumulants encode richer information. We further consider the double-scaled limit of SYKq at infinite temperature, where q ~ $$ \sqrt{N} $$

N

. In such a limit, we find that the scrambling time shrinks to zero, and the Lanczos coefficients diverge. The growth of Krylov complexity appears to be “hyperfast”, which is previously conjectured to be associated with scrambling in de Sitter space.
Flavor-dependent long-range neutrino interactions in DUNE & T2HK: alone they constrain, together they discover
Authors: Singh Masoom , Bustamante Mauricio , Agarwalla Sanjib Kumar 
Published: August 2023

Abstract
Discovering new neutrino interactions would represent evidence of physics beyond the Standard Model. We focus on new flavor-dependent long-range neutrino interactions mediated by ultra-light mediators, with masses below 10−10 eV, introduced by new lepton-number gauge symmetries Le – Lμ, Le – Lτ, and Lμ – Lτ. Because the interaction range is ultra-long, nearby and distant matter — primarily electrons and neutrons — in the Earth, Moon, Sun, Milky Way, and the local Universe, may source a large matter potential that modifies neutrino oscillation probabilities. The upcoming Deep Underground Neutrino Experiment (DUNE) and the Tokai-to-Hyper-Kamiokande (T2HK) long-baseline neutrino experiments will provide an opportunity to search for these interactions, thanks to their high event rates and well-characterized neutrino beams. We forecast their probing power. Our results reveal novel perspectives. Alone, DUNE and T2HK may strongly constrain long-range interactions, setting new limits on their coupling strength for mediators lighter than 10−18 eV. However, if the new interactions are subdominant, then both DUNE and T2HK, together, will be needed to discover them, since their combination lifts parameter degeneracies that weaken their individual sensitivity. DUNE and T2HK, especially when combined, provide a valuable opportunity to explore physics beyond the Standard Model.
Information loss, mixing and emergent type III1 factors
Authors: Furuya Keiichiro , Lashkari Nima , Moosa Mudassir , Ouseph Shoy 
Published: August 2023

Abstract
A manifestation of the black hole information loss problem is that the two-point function of probe operators in a large Anti-de Sitter black hole decays in time, whereas, on the boundary CFT, it is expected to be an almost periodic function of time. We point out that the decay of the two-point function (clustering in time) holds important clues to the nature of observable algebras, states, and dynamics in quantum gravity.We call operators that cluster in time “mixing” and explore the necessary and sufficient conditions for mixing. The information loss problem is a special case of the statement that in type I algebras, there exists no mixing operators. We prove that, in a thermofield double state (KMS state), if mixing operators form an algebra (close under multiplication), the resulting algebra must be a von Neumann type III1 factor. In other words, the physically intuitive requirement that all nonconserved operators should exponentially mix is so strong that it fixes the observable algebra to be an exotic algebra called a type III1 factor. More generally, for an arbitrary out-of-equilibrium state of a general quantum system (von Neumann algebra), we show that if the set of operators that mix under modular flow forms an algebra, it is a type III1 von Neumann factor.In a theory of Generalized Free Fields (GFF), we show that if the two-point function clusters in time, all operators are mixing, and the algebra is a type III1 factor. For example, in 𝒩 = 4 SYM, above the Hawking-Page phase transition, clustering of the single trace operators implies that the algebra is a type III1 factor, settling a recent conjecture of Leutheusser and Liu. We explicitly construct the C∗-algebra and von Neumann subalgebras of GFF associated with time bands and, more generally, open sets of the bulk spacetime using the HKLL reconstruction map.
A small remark on Bernstein’s theorem
Authors: Bildhauer Michael , Farquhar Bernhard , Fuchs Martin 
Published: August 2023

AbstractWe investigate splitting-type variational problems with some linear growth conditions. For balanced solutions of the associated Euler–Lagrange equation, we receive a result analogous to Bernstein’s theorem on non-parametric minimal surfaces. Without assumptions of this type, Bernstein’s theorem cannot be carried over to the splitting case, which follows from an elementary counterexample. We also include some modifications of our main theorem.
Protease-independent control of parthanatos by HtrA2/Omi
Authors: Weiß Jonas , Heib Michelle , Korn Thiemo , Hoyer Justus , Fuchslocher Chico Johaiber , Voigt Susann , Koudelka Tomas , Tholey Andreas , Adam Dieter 
Published: August 2023

AbstractHtrA2/Omi is a mitochondrial serine protease with ascribed pro-apoptotic as well as pro-necroptotic functions. Here, we establish that HtrA2/Omi also controls parthanatos, a third modality of regulated cell death. Deletion of HtrA2/Omi protects cells from parthanatos while reconstitution with the protease restores the parthanatic death response. The effects of HtrA2/Omi on parthanatos are specific and cannot be recapitulated by manipulating other mitochondrial proteases such as PARL, LONP1 or PMPCA. HtrA2/Omi controls parthanatos in a manner mechanistically distinct from its action in apoptosis or necroptosis, i.e., not by cleaving cytosolic IAP proteins but rather exerting its effects without exiting mitochondria, and downstream of PARP-1, the first component of the parthanatic signaling cascade. Also, previously identified or candidate substrates of HtrA2/Omi such as PDXDC1, VPS4B or moesin are not cleaved and dispensable for parthanatos, whereas DBC-1 and stathmin are cleaved, and thus represent potential parthanatic downstream mediators of HtrA2/Omi. Moreover, mass-spectrometric screening for novel parthanatic substrates of HtrA2/Omi revealed that the induction of parthanatos does not cause a substantial proteolytic cleavage or major alterations in the abundance of mitochondrial proteins. Resolving these findings, reconstitution of HtrA2/Omi-deficient cells with a catalytically inactive HtrA2/Omi mutant restored their sensitivity against parthanatos to the same level as the protease-active HtrA2/Omi protein. Additionally, an inhibitor of HtrA2/Omi’s protease activity did not confer protection against parthanatic cell death. Our results demonstrate that HtrA2/Omi controls parthanatos in a protease-independent manner, likely via novel, unanticipated functions as a scaffolding protein and an interaction with so far unknown mitochondrial proteins.
Higher revision rates in patients with preoperative contralateral pes planovalgus deformity following total knee arthroplasty
Authors: Pearson Zachary C. , Harris Andrew B. , Agarwal Amil R. , Kreulen R. Timothy , Martin Jalen , Ahiarakwe Uzoma , Golladay Gregory J. , Thakkar Savyasachi C. 
Published: August 2023

AbstractPurposeThe purpose of this study was to compare the incidence of revision in those with pes planovalgus deformity to those without using a large national database. Given the reciprocal changes in lower extremity alignment associated with planovalgus foot deformity, it has been suggested that patients with this deformity has worse outcomes following total knee arthroplasty (TKA).MethodsA retrospective cohort analysis of patients undergoing elective TKA was conducted using the PearlDiver database. Patients were stratified into three cohorts: those without pes planovalgus, patients with ipsilateral or bilateral pes planovalgus relative to the TKA, and patients with contralateral pes planovalgus. Patients with prior foot reconstructive surgery were excluded. The cohorts were each matched to those without pes planovalgus. Bivariate analysis was performed comparing 90‐day medical complications and 2‐ and 4‐year revisions following TKA. An adjusted number needed to be exposed for one additional person to be harmed (NNEH) was calculated using the adjusted odds ratio (OR) and unexposed event rate.ResultsFollowing matched analysis, those with contralateral pes planovalgus had similar odds (OR 3.41; 95% CI 0.93–12.54; p = n.s.) for aseptic revision within 2 years but significantly higher odds (OR 3.35; 95% CI 1.08–10.41; p = 0.03) within 4 years when compared to those without a pes planovalgus deformity. Within 4 years, there was no significant difference in the incidence of aseptic revision (p = n.s.) in patients with ipsilateral/bilateral pes planovalgus. No patients in any cohort underwent septic revision within 4 years of TKA.ConclusionThis study found that patients with contralateral pes planovalgus deformity had higher odds of aseptic revision within 4 years following primary TKA in a national database, suggesting that the change in gait kinematics associated with this deformity could possibly be associated with increased revision rates.Level of evidenceLevel III.
Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice
Authors: Sousa Adelaide , Azevedo Rui , Costa Vera Marisa , Oliveira Sara , Preguiça Inês , Viana Sofia , Reis Flávio , Almeida Agostinho , Matafome Paulo , Dias-Pereira Patrícia , Carvalho Félix , Fernandes Eduarda , Freitas Marisa 
Published: August 2023

AbstractSilver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines.
Reduced order modelling using neural networks for predictive modelling of 3d-magneto-mechanical problems with application to magnetic resonance imaging scanners
Authors: Miah S. , Sooriyakanthan Y. , Ledger P. D. , Gil A. J. , Mallett M. 
Published: August 2023

AbstractThe design of magnets for magnetic resonance imaging (MRI) scanners requires the numerical simulation of a coupled magneto-mechanical system where the effects that different material parameters and in-service loading conditions have on both imaging and MRI performance are key to aid with the design and the manufacturing process. To correctly capture the complex physics, and to obtain accurate solutions, finite element simulations with dense meshes and high order elements are needed. Reduced order model approaches, based on the established proper orthogonal decomposition (POD) approach, are attractive as they can rapidly predict the numerical simulations needed under changing parameters or conditions. However, the projected (PODP) approach has an invasive computational implementation, whilst the interpolated (PODI) approach presents challenges when the dimension of the space of parameters to be investigated becomes large. As an alternative, we investigate a POD technique based on using a neural network regression, which is not as invasive as PODP, but has superior approximation properties compared to PODI. We apply this to the coupled magneto-mechanical system to understand three pressing industrial problems: firstly, the accurate and rapid computation of the resonant frequencies associated with this coupled magneto-mechanical system, secondly, the effects of magnet motion on the Ohmic power and kinetic energy curves, and, thirdly, the prediction of the uncertainty in Ohmic power and kinetic energy curves as a function of exciting frequency for uncertain material parameters.