bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence mechanism of service innovation on consumer mobile sharing in the age of digital intelligence
Authors: Peng Hongxia , Xu Shuwei , Yang Mei 
Published: August 2023

IntroductionDigitalization is moving closer to traditional service companies. Consumers have new behavioral characteristics, and operators need to adopt new marketing strategies.MethodsWe used CiteSpace software to analyze the literature related to customer delight in CNKI and Web of Science databases. We constructed models and research hypotheses based on theoretical studies related to customer delight and mobile sharing. The data were collected through questionnaires and the article used structural equation modeling and regression analysis to test the mediating role of customer delight and the moderating role of individual innovativeness in the theoretical model.ResultsAmong the four dimensions of service innovation, only interface innovation and delivery innovation, affect consumers' mobile sharing through customer delight, and customer delight has a very significant positive impact on mobile sharing. The mediating effect of customer delight is affected by the individual innovation of consumers in the path of delivering innovation.DiscussionIn the future, catering and takeaway companies can innovate the delivery process of product information to reach consumers, and provide a personalized interface to accurately meet the different needs of customers.
Possible genetic relationship between Mesozoic magmatic rocks and gold mineralization in the Jiaodong Peninsula (Eastern China): constraints of magmatic evolution and physicochemical conditions
Authors: Li Jian , Dai Chang-Guo , Wang Chang-Wei , Song Ming-Chun , Wang Chang-Jiang , Li Shi-Yong , Wang Run-Sheng , Shi Hong-Jiang , Xu Kai-Lei , Wang Ping 
Published: August 2023

The Jiaodong Peninsula is China’s largest gold province and the third largest in the world. Although gold mineralization is associated with Mesozoic granites temporally and spatially, the specific genetic association remains unclear, leading to ambiguity regarding the genetic type of gold deposits. To address this issue, we conducted whole-rock major and trace elements, LA–ICP–MS zircon U–Pb geochronology and trace elements geochemical analyses on the Linglong (Linglong suite), Yashan, and Nansu (Weideshan suite) plutons, and compiled contemporaneous magmatic rock data. Our results show that the granites were emplaced at 161 ± 2, 118 ± 1, and 121 ± 2 Ma, respectively. Geochemically, these rocks exhibit high Al2O3 (12.73–14.10 wt%) content and Sr/Y (35.54–136.50) ratio, and low Y (3.26–11.20 ppm) and Yb (0.33–0.97 ppm) contents, indicating the adakitic rock properties. They were formed through partial melting of the thickened lower crust associated with subduction of the paleo-Pacific Plate. The Early Cretaceous granites contain a large amount of mafic microgranular enclaves, indicating the presence of mantle material mixing in the source area. Zircon trace elements show that the pre-mineralization magma (Linglong) had relatively low oxygen fugacity and temperature (ΔFMQ = −2.5 to +1.9, T-Ti in zircon (mean) = 740°C) compared to the mineralization magma (ΔFMQ = +0.5 to +3.9, T-Ti in zircon (mean) = 755°C). The physicochemical conditions in the pre-mineralization magma source area may be favorable for sulfide accumulation (may including gold). During the Early Cretaceous, North China Craton decratonization reached its climax, and a large number of adakitic crust-mantle mixed oxidized magma upwells, allowing for the migration and mineralization of a large amount of sulfides and gold. This model helps explain the transient, explosive, and genetic categories in Jiaodong gold deposits.
Evolution of residual strain and strain energy in rocks under various types of uniaxial cyclic loading-unloading
Authors: Liu Zhixi , Liu Xiaodie 
Published: August 2023

In the process of roadway excavation, the rock mass around the roadway is often subjected to cyclic loads, and the rock mechanical properties and strain energy evolution under cyclic loads are obviously different from those under compression, so it is urgent to carry out research on rock mechanical properties and strain energy evolution under cyclic loads. This study aims to investigate the evolution of residual strain and strain energy in rocks under uniaxial cyclic loading-unloading experiments (UCLUE). Four types of rocks, namely coal, white sandstone, red sandstone, and granite, were subjected to uniaxial compression experiments (UCE) and various uniaxial cyclic loading-unloading experiments (UEACLUE). The findings are as follows: analysis of UEACLUE revealed a gradual decrease in residual strain with an increasing number of cycles, leading to its eventual disappearance. However, if the cyclic loading-unloading (CLU) was continued beyond this point, the rocks displayed a reappearance of residual strain. The number of cycles required to eliminate residual strain was found to be inversely proportional to the peak strength of the rocks, while directly proportional to the upper limit value of UCLUE. Among the different stages of the uniaxial cyclic loading and unloading test, the plastic stage of white sandstone exhibited the largest disparity in dissipated strain energy, followed by the plastic stage of red sandstone, with coal displaying the smallest difference. Analysis of dissipated strain energy in the four types of uniaxial cyclic loading and unloading tests revealed differences of 0.00348 mJ▪mm−3, 0.03488 mJ▪mm−3, 0.02763 mJ▪mm−3, and 0.01619 mJ▪mm−3 in the plastic stage for the respective rock types. Furthermore, examination of the input strain energy density (ISED) and dissipated strain energy density (DSED) during the CLU process showed a linear relationship between these variables. Additionally, the investigation of ISED and DSED in other types of UCLUE demonstrated adherence to the cyclic-linear dissipation law (CLDL). The study of mechanical properties and strain energy evolution under CLU is of positive significance for the development of rock fatigue damage and rock damage mechanics.
First insights into the Aurelia aurita transcriptome response upon manipulation of its microbiome
Authors: Weiland-Bräuer Nancy , Koutsouveli Vasiliki , Langfeldt Daniela , Schmitz Ruth A. 
Published: August 2023

IntroductionThe associated diverse microbiome contributes to the overall fitness of Aurelia aurita, particularly to asexual reproduction. However, how A. aurita maintains this specific microbiome or reacts to manipulations is unknown.MethodsIn this report, the response of A. aurita to manipulations of its native microbiome was studied by a transcriptomics approach. Microbiome-manipulated polyps were generated by antibiotic treatment and challenging polyps with a non-native, native, and potentially pathogenic bacterium. Total RNA extraction followed by RNAseq resulted in over 155 million reads used for a de novo assembly.ResultsThe transcriptome analysis showed that the antibiotic-induced change and resulting reduction of the microbiome significantly affected the host transcriptome, e.g., genes involved in processes related to immune response and defense mechanisms were highly upregulated. Similarly, manipulating the microbiome by challenging the polyp with a high load of bacteria (2 × 107 cells/polyp) resulted in induced transcription of apoptosis-, defense-, and immune response genes. A second focus was on host-derived quorum sensing interference as a potential defense strategy. Quorum Quenching (QQ) activities and the respective encoding QQ-ORFs of A. aurita were identified by functional screening a cDNA-based expression library generated in Escherichia coli. Corresponding sequences were identified in the transcriptome assembly. Moreover, gene expression analysis revealed differential expression of QQ genes depending on the treatment, strongly suggesting QQ as an additional defense strategy.DiscussionOverall, this study allows first insights into A. aurita’s response to manipulating its microbiome, thus paving the way for an in-depth analysis of the basal immune system and additional fundamental defense strategies.
Gut microbiota and cerebrovascular diseases: a Mendelian randomization study
Authors: Qin Hao , Yang Fan , Hao Pengfei , Zhang Xianfeng 
Published: August 2023

BackgroundThe causal relationship between gut microbiota and cerebrovascular disease remains unknown, despite several recent studies reporting an association between the two.MethodsTo assess this relationship, we conducted a two-sample Mendelian randomization (MR) using summary statistics data from published genome-wide association studies (GWAS). This analysis allowed us to identify bacterial taxa that may affect cerebrovascular disease. Furthermore, we performed reverse MR to further analyze the significant bacterial taxa. Finally, we conducted a two-step MR analysis to examine the mediating role of metabolic factors [systolic blood pressure (SBP), type 2 diabetes (T2D), and body mass index (BMI)] in the association between gut microbiota and cerebrovascular disease. Additionally, a series of sensitivity analyses were carried out to validate the robustness of our findings.ResultsOur results showed that a genetically predicted high abundance of family Porphyromonadaceae reduced the risk of intracranial aneurysms (IA). Moreover, using inverse variance weighted (IVW) estimates, we found a nominal causal relationship between seventeen gut microbiota and IA, as well as its subtypes. In the case of stroke and its subtypes, we observed a nominal causal relationship with thirteen, eleven, eleven, nine, and eight bacteria for AS, AIS, CES, LAS, and SVS, respectively. Reverse MR analysis showed no significant causal relationship between intracranial aneurysms and gut microbiota. However, we did find that genetically predicted any stroke (AS) and any ischemic stroke (AIS) reduced the abundance of family Clostridiaceae1 (OR: 0.74, 95% CI: 0.62–0.87, p = 3.39 × 10−4, and OR: 0.75, 95% CI: 0.66–0.87, p = 7.06 × 10−5, respectively). Furthermore, genetic prediction of AIS (OR: 0.87, 95% CI: 0.77–0.99, p = 3.05 × 10−2) was associated with a reduced abundance of the order Clostridiales. Moreover, genus Streptococcus exhibited effects on AS, AIS, and SVS which were mediated by T2D. Conversely, the association between genus Eubacterium brachy group and AIS was mediated by SBP. No significant heterogeneity of instrumental variables or horizontal pleiotropy was observed.ConclusionThis MR analysis indicates that there exists a beneficial or detrimental causal effect of gut microbiota composition on cerebrovascular disease. And SBP and T2D may play mediating role in this process.
The mitogenomes of Leptographium aureum, Leptographium sp., and Grosmannia fruticeta: expansion by introns
Authors: Mukhopadhyay Jigeesha , Wai Alvan , Hausner Georg 
Published: August 2023

IntroductionMany members of the Ophiostomatales are of economic importance as they are bark-beetle associates and causative agents for blue stain on timber and in some instances contribute towards tree mortality. The taxonomy of these fungi has been challenging due to the convergent evolution of many traits associated with insect dispersal and a limited number of morphological characters that happen to be highly pleomorphic. This study examines the mitochondrial genomes for three members of Leptographium sensu lato [Leptographium aureum (also known as Grosmannia aurea), Grosmannia fruticeta (also known as Leptographium fruticetum), and Leptographium sp. WIN(M)1376)].MethodsIllumina sequencing combined with gene and intron annotations and phylogenetic analysis were performed.ResultsSequence analysis showed that gene content and gene synteny are conserved but mitochondrial genome sizes were variable: G. fruticeta at 63,821 bp, Leptographium sp. WIN(M)1376 at 81,823 bp and L. aureum at 104,547 bp. The variation in size is due to the number of introns and intron-associated open reading frames. Phylogenetic analysis of currently available mitochondrial genomes for members of the Ophiostomatales supports currently accepted generic arrangements within this order and specifically supports the separation of members with Leptographium-like conidiophores into two genera, with L. aureum grouping with Leptographium and G. fruticeta aligning with Grosmannia.DiscussionMitochondrial genomes are promising sequences for resolving evolutionary relationships within the Ophiostomatales.
The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study
Authors: Yang Xiao-hui , Liu Xiao-hui , Ma Yun-gai , Fan Jia-xing , Ma Xiao-long , Zhuang Guan-ying , Yang Zhan-min 
Published: August 2023

ObjectiveThis randomized double-blinded clinical study is to investigate the clinical efficacy of per-paravertebral disk ozone injection combined with steroids in the treatment of patients with chronic discogenic low back pain (CDLBP).MethodsGroup A (N = 60) received a per-paravertebral injection of a steroid mixture of 10 mL with pure oxygen 20 mL, while group B (N = 60) received a per-paravertebral injection of a steroid mixture of 10 mL combined with ozone 20 mL (30 μg/mL). Injections were administered once a week for 3 weeks, with a follow-up of 6 months. Clinical outcomes were assessed at week 1, month 3, and month 6 with the help of Visual Analog Scale (VAS) scores and Macnab efficacy evaluation.ResultsThe VAS score of both group A (1.65 vs. 6.87, p = 0.000) and group B (1.25 vs. 6.85, p = 0.000) at week 1 was significantly reduced compared to baseline. The effect was sustained at the 3- and 6-month follow-up periods (p &lt; 0.05). Group B had significantly lower VAS scores at month 3 (1.53 vs. 3.82, p = 0.000) and month 6 (2.80 vs. 5.05, p = 0.000) compared to group A, respectively. Based on Macnab criteria, 95 and 96.7% of patients in groups A and B had good rates “excellent plus good” at week 1, respectively. Good rates were significantly higher in group B at month 3 (91.7 vs. 78.3%, p = 0.041) and month 6 (85.0 vs. 68.3%, p = 0.031) compared to group A, respectively. No serious adverse events were noted in both groups.ConclusionPer-paravertebral injection of steroid and ozone combination resulted in better relief of CDLBP compared to pure oxygen plus steroid.Clinical Trial RegistrationChiCTR2100044434 https://www.chictr.org.cn/showproj.html?proj=121571.
Distinct characteristics and severity of brain magnetic resonance imaging lesions in women and men with multiple sclerosis assessed using verified texture analysis measures
Authors: Hosseinpour Zahra , Oladosu Olayinka , Liu Wei-qiao , Pike G. Bruce , Yong V. Wee , Metz Luanne M. , Zhang Yunyan 
Published: August 2023

Background and goalIn vivo characterization of brain lesion types in multiple sclerosis (MS) has been an ongoing challenge. Based on verified texture analysis measures from clinical magnetic resonance imaging (MRI), this study aimed to develop a method to identify two extremes of brain MS lesions that were approximately severely demyelinated (sDEM) and highly remyelinated (hREM), and compare them in terms of common clinical variables.MethodTexture analysis used an optimized gray-level co-occurrence matrix (GLCM) method based on FLAIR MRI from 200 relapsing-remitting MS participants. Two top-performing metrics were calculated: texture contrast and dissimilarity. Lesion identification applied a percentile approach according to texture values calculated: ≤ 25 percentile for hREM and ≥75 percentile for sDEM.ResultsThe sDEM had a greater total normalized volume yet smaller average size, and worse MRI texture than hREM. In lesion distribution mapping, the two lesion types appeared to overlap largely in location and were present the most in the corpus callosum and periventricular regions. Further, in sDEM, the normalized volume was greater and in hREM, the average size was smaller in men than women. There were no other significant results in clinical variable-associated analyses.ConclusionPercentile statistics of competitive MRI texture measures may be a promising method for probing select types of brain MS lesion pathology. Associated findings can provide another useful dimension for improved measurement and monitoring of disease activity in MS. The different characteristics of sDEM and hREM between men and women likely adds new information to the literature, deserving further confirmation.
Pretreatment diffusion-weighted imaging for prediction of relapsed and refractory primary central nervous system lymphoma
Authors: Chien Hsi-Cheng , Yeh Lee-Ren , Hung Kuo-Chuan , Lim Sher-Wei , Cheng Chung-Yu , Lee Yu-Chang , Chen Jeon-Hor , Ko Ching-Chung 
Published: August 2023

ObjectivesA subset of primary central nervous system lymphoma (PCNSL) has been shown to undergo an early relapsed/refractory (R/R) period after first-line chemotherapy. This study investigated the pretreatment clinical and MRI features to predict R/R in PCNSL, emphasizing the apparent diffusion coefficient (ADC) values in diffusion-weighted imaging (DWI).MethodsThis retrospective study investigated the pretreatment MRI features for predicting R/R in PCNSL. Only patients who had undergone complete preoperative and postoperative MRI follow-up studies were included. From January 2006 to December 2021, 52 patients from two medical institutions with a diagnosis of PCNSL were included (median follow-up time, 26.3 months). Among these, 24 (46.2%) had developed R/R (median time to relapse, 13 months). Cox proportional hazard regression analyses were performed to determine hazard ratios for all parameters.ResultsSignificant predictors of R/R in PCNSL were female sex, complete response (CR) to first-line chemotherapy, and ADC value/ratio (p &lt; 0.05). Cut-off points of ADC values and ADC ratios for prediction of R/R were 0.68 × 10−3 mm2/s and 0.97, with AUCs of 0.78 and 0.77, respectively (p &lt; 0.05). Multivariate Cox proportional hazards analysis showed that failure of CR to first-line chemotherapy and low ADC values (&lt;0.68 × 10−3 mm2/s) were significant risk factors for R/R, with hazard ratios of 5.22 and 14.45, respectively (p &lt; 0.05). Kaplan–Meier analysis showed that lower ADC values and ratios predicted significantly shorter progression-free survival (p &lt; 0.05).ConclusionPretreatment ADC values in DWI offer quantitative valuable information for the treatment planning in PCNSL.
Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder
Authors: Huang Wenxian , Fateh Ahmed Ameen , Zhao Yilin , Zeng Hongwu , Yang Binrang , Fang Diangang , Zhang Linlin , Meng Xianlei , Hassan Muhammad , Wen Feiqiu 
Published: August 2023

ObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits in ADHD, little is known about its specific impact on the hippocampus. The goal of the current study was to determine how variations in ADHD’s SNAP-25 Mnll polymorphism (rs3746544) affect hippocampal functional connectivity (FC).MethodsA total of 88 boys between the ages of 7 and 10 years were recruited for the study, including 60 patients with ADHD and 28 healthy controls (HCs). Data from resting-state functional magnetic resonance imaging (rs-fMRI) and clinical information were acquired and assessed. Two single nucleotide polymorphisms (SNP) in the SNAP-25 gene were genotyped, according to which the study’s findings separated ADHD patients into two groups: TT homozygotes (TT = 35) and G-allele carriers (TG = 25).ResultsBased on the rs-fMRI data, the FC of the right hippocampus and left frontal gyrus was evaluated using group-based comparisons. The corresponding sensitivities and specificities were assessed. Following comparisons between the patient groups, different hippocampal FCs were identified. When compared to TT patients, children with TG had a lower FC between the right precuneus and the right hippocampus, and a higher FC between the right hippocampus and the left middle frontal gyrus.ConclusionThe fundamental neurological pathways connecting the SNAP-25 Mnll polymorphism with ADHD via the FC of the hippocampus were newly revealed in this study. As a result, the hippocampal FC may further serve as an imaging biomarker for ADHD.
Body composition as a predictor of oncological outcome in patients with non-muscle-invasive bladder cancer receiving intravesical instillation after transurethral resection of bladder tumor
Authors: Huang Liang-Kang , Lin Yu-Ching , Chuang Hai-Hua , Chuang Cheng-Keng , Pang See-Tong , Wu Chun-Te , Chang Ying-Hsu , Yu Kai-Jie , Lin Po-Hung , Kan Hung-Cheng , Chu Yuan-Cheng , Hung Wei-Kang , Hsieh Ming-Li , Shao I-Hung 
Published: August 2023

IntroductionBody status, categorized as sarcopenia or obesity and assessed using body mass index and body composition, affects the outcome of bladder cancer patients. However, studies comparing disease progression, recurrence, or overall survival in patients with non-muscle-invasive bladder cancer (NMIBC) with different body compositions are lacking. Therefore, we conducted a retrospective study to identify the impact of body composition, sarcopenia, and obesity on the oncological prognosis of patients with NMIBC who underwent transurethral resection of bladder tumor (TURBT) with Bacillus Calmette-Guerin (BCG) intravesical instillation (IVI).MethodsPatients with NMIBC who had undergone TURBT with adjuvant IVI with BCG from March 2005 to April 2021 were included. Body composition parameters were evaluated using computed tomography images of the third lumbar vertebrae and further categorized by sarcopenia and obesity. Oncological outcomes including recurrence-free survival (RFS), progression-free survival, and overall survival (OS) after treatment were analyzed.ResultsA total of 269 patients were enrolled. Subcutaneous adipose tissue (SAT) density was a significant predictor of RFS, whereas psoas muscle density was a significant predictor of OS in the multivariate analysis. Patients with sarcopenia but without obesity tolerated significantly fewer BCG IVIs than patients without sarcopenia or obesity. Patients with sarcopenia had poorer RFS and OS than those without sarcopenia. In contrast, patients with obesity had better OS than those without obesity.DiscussionBody composition parameters, including SAT density and psoas muscle density, emerged as significant predictors of OS and RFS, respectively. Hence, our findings indicate that body composition is a helpful measurement to assess the oncological outcomes of patients with NMIBC.