bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orchiectomy due to delayed severe scrotal hematocele after laparoscopic transabdominal preperitoneal repair for a giant inguinoscrotal hernia: a case report
Authors: Nakamura Kenichi , Shibasaki Susumu , Takenaka Masashi , Serizawa Akiko , Akimoto Shingo , Nakauchi Masaya , Tanaka Tsuyoshi , Inaba Kazuki , Shiroki Ryoichi , Uyama Ichiro , Suda Koichi 
Published: December 2022

Abstract
Background
A giant inguinoscrotal hernia is a rare inguinal hernia that extends below the midpoint of the inner thigh while standing. Although reports of laparoscopic surgery for giant inguinoscrotal hernias have increased, the risk of delayed hematocele has not yet been clarified.

Case presentation
A 68-year-old man was evaluated for a left giant inguinoscrotal hernia, and laparoscopic transabdominal preperitoneal repair (TAPP) was performed. In the procedure, the distal hernia sac was not resected. The postoperative course was uneventful for 3 months postsurgery, after which he complained of giant scrotal swelling, which gradually grew to 13 cm. It did not improve with several punctures and caused dysuria because of increased pressure on the urethra. Thus, reoperation was performed 9 months after surgery. The hematocele consisted of a thickened hernia sac, which was tightly adhered to the spermatic cord and testicle. The hernia sac including the hematocele was removed from the scrotum through an anterior approach, preserving the spermatic cord and testicle. On the third postoperative day, an orchiectomy was performed due to poor testicular perfusion caused by spermatic cord injury. There was no hematocele or hernia at the 3-year follow-up. The remnant sac after laparoscopic TAPP for a giant inguinoscrotal hernia possibly caused refractory hematocele. Additionally, the removal of the hernia sac, including hematocele, from the spermatic cord and testicle has a risk of inducing injury, leading to orchiectomy.

Conclusion
Surgeons should be aware of the possibility of delayed refractory hematoceles after laparoscopic TAPP for giant inguinoscrotal hernias when the hernia sac is not resected.
Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
Authors: Krishnan Sridevi , Freytag Tammy , Jiang Xiaowen , Schuster Gertrud U. , Woodhouse Leslie R. , Keim Nancy L. , Stephensen Charles B. 
Published: December 2022

Abstract
Objective
To evaluate the effect of a diet pattern based on Dietary Guidelines for Americans (DGA), in a controlled feeding setting, on plasma markers of inflammation and on cytokine production by peripheral blood mononuclear cells (PBMC).

Design
Women (n = 44) with one or more risk factors of metabolic syndrome (and BMI: 25.2-39.8 kg/m2) completed an 8-wk controlled feeding study. They were randomized to either a group following a diet based on DGA 2010 (DGA), or a group given a ‘typical American diet’ (TAD), based largely on a Western diet pattern. By design, women maintained their body weight. Fasting plasma and PBMC were collected at wk. 0 (baseline) and at wk. 8 (post-intervention). Sixteen plasma markers of inflammation and eight PBMC cytokines were measured at both time points, to evaluate if the diet had a significant effect on concentrations of these inflammatory markers. Data were analyzed using ANCOVA, followed by multiple-comparison adjustment using Benjamini-Hochberg method.

Results
Significant changes observed in Serum Amyloid A (SAA) and Matrix Metalloproteinase 3 (MMP3) in plasma did not retain significance upon multiple comparison adjustment. SAA: p = 0.044, adj p = 0.450; DGA mean change [95% CI] = − 12.6[− 32.3 to 7.04]; TAD mean change [95% CI] = − 2.24 [− 9.99 to 5.51]. MMP3: p = 0.014, adj p = 0.35; DGA mean change [95% CI] = 2.72[− 4.16 to 9.59]; TAD mean change [95% CI] = − 0.98[− 16.7 to 14.7]). Other inflammation markers were not differently altered by DGA relative to TAD. Effect size of change (Cohens d) indicated a large/medium-large effect of intervention on MMP3 and CRP, and medium effect on IL-6.

Conclusions
No statistically significant changes were observed in the immune markers examined in this study. The biological roles and magnitude of the non-significant differences seen with two variables, CRP and MMP3, suggest that they be examined in future studies.

Trial registration
Clinicaltrials.gov identifier NCT02298725.
Describing the growth and nutritional status of sickle cell disease children and adolescents with reference to WHO growth standards in Cameroon
Authors: Charlotte Eposse Ekoube , Ritha Carole Mbono Betoko , Calixthe Ida Penda , Jeanne Georgette Mony Elimbi , Patricia Epee , Iyawa Hassanatou , Edgar Mandeng Ma Linwa , Michael Ngenge Budzi , Gaelle Ntsoli Kofane , Claudia Ekame Bulu Bianca , Dicka Sajida Misse , Paul Koki Ndombo , Daniele-Christiane Kedy Mangamba Koum 
Published: December 2022

Abstract
Background
Sickle cell disease (SCD) is a chronic disease with many complications among which is growth retardation. Here, we described the growth and nutritional status patterns of children with SCD and adolescents living in Douala, Cameroon.

Methods
This cross-sectional study took place at the sickle cell treatment center of Douala Laquintinie Hospital from November 2015 to April 2016. The sociodemographic and anthropometric information of each SCD patient was determined, and then used for computing z-score indexes (weight for age, weight for height, body mass index for height, and height for age). The different indexes were used to determine the prevalence of malnutrition forms (stunting, wasting, underweight, and overweight/obesity) and compared to WHO standards by gender and age.

Results
A total of 208 children and adolescents participated in the study. The mean age was 8 years (±5) and the median age was 7 years. Males accounted for 53.4% of cases, giving a sex ratio of 1:1.1. The proportions of wasting, stunting, underweight, and overweight/obesity in the overall population were 7.1% (n = 15), 9.1% (n = 19), 3.6% (n = 5) and 3.3% (n = 7) respectively. In children under 5, wasting, stunting, underweight, and overweight/obesity were noted in 1.4% (n = 1), 9.5% (n = 7), 1.4% (n = 1), and 5.4% (n = 4) respectively. In patients aged 5 years and above, a proportion of 10.5% (n = 14) was wasted, 9.0% (n = 12) were stunted, 5.9% (n = 4) were underweight and 2.2% (n = 7) were overweight/obese. The growth curve of children under five in our study was superimposable to the WHO standard growth curve. In children older than 5 years, the left shift for stunting was more pronounced for boys compared to girls.

Conclusion
Nine percent of children and adolescents with SCD are stunted. The growth deficit appeared to be higher in patients aged 5 years and above, more particularly in boys than girls. Overweight/obesity was uncommon in our series. More robust research designs and statistical analyses are needed to confirm or refute these findings.
Artificial intelligence in nonalcoholic fatty liver disease
Authors: Mahzari Ali 
Published: December 2022

Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) has led to serious health-related complications worldwide. NAFLD has wide pathological spectra, ranging from simple steatosis to hepatitis to cirrhosis and hepatocellular carcinoma. Artificial intelligence (AI), including machine learning and deep learning algorithms, has provided great advancement and accuracy in identifying, diagnosing, and managing patients with NAFLD and detecting squeal such as advanced fibrosis and risk factors for hepatocellular cancer. This review summarizes different AI algorithms and methods in the field of hepatology, focusing on NAFLD.

Methods
A search of PubMed, WILEY, and MEDLINE databases were taken as relevant publications for this review on the application of AI techniques in detecting NAFLD in suspected population

Results
Out of 495 articles searched in relevant databases, 49 articles were finally included and analyzed. NASH-Scope model accurately distinguished between NAFLD and non-NAFLD and between NAFLD without fibrosis and NASH with fibrosis. The logistic regression (LR) model had the highest accuracy, whereas the support vector machine (SVM) had the highest specificity and precision in diagnosing NAFLD. An extreme gradient boosting model had the highest performance in predicting non-alcoholic steatohepatitis (NASH). Electronic health record (EHR) database studies helped the diagnose NAFLD/NASH. Automated image analysis techniques predicted NAFLD severity. Deep learning radiomic elastography (DLRE) had perfect accuracy in diagnosing the cases of advanced fibrosis.

Conclusion
AI in NAFLD has streamlined specific patient identification and has eased assessment and management methods of patients with NAFLD.
Characteristics of clinical isolates of nontuberculous mycobacteria in Java-Indonesia: A multicenter study
Authors: Saptawati Leli , Primaningtyas Widana , Dirgahayu Paramasari , Sutanto Yusup Subagio , Wasita Brian , Suryawati Betty , Nuryastuti Titik , Probandari Ari 
Published: December 2022

Background
Nontuberculous mycobacterial (NTM) lung infections are a major public health concern. Diagnosis of NTM-pulmonary disease (NTM-PD) is difficult because its clinical, microbiological, and radiological features resemble to those of pulmonary tuberculosis (TB), leading to misdiagnosis. Identification at the species level is essential for diagnosis and determination of therapy, which is currently not performed routinely in Indonesian laboratories.

Methodology and principal findings
From January 2020 to May 2021, 94 NTM isolates were collected from three TB referral centers in Java Province. Species were identified using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). Tests were performed to determine antibiotic susceptibility, biofilm formation ability, sliding motility characteristics, and the ability to adhere to and invade pneumocytes. After identifying the species of all the isolates, we found nine groups of NTMs: M. fortuitum group 51% (48/94), M. abscessus 38.3% (36/94), M. intracellulare 3.1% (3/94), M. neoaurum 2.1% (2/94), M. chelonae 1.1% (1/94), M. gordonae 1.1% (1/94), M. szulgai 1.1% (1/94), M. mucogenicum 1.1% (1/94), and M. arupense 1.1% (1/94). Amikacin was the most effective antibiotic against M. fortuitum group and M. abscessus. The M. fortuitum group was significantly better at forming biofilms than M. abscessus, but both had the same sliding motility capability. The ability of the M. fortuitum group to adhere to and invade pneumocytes was better than that of M. abscessus, with the number isolates of the M. fortuitum group capable of superior adhesion and invasion to that of M. abscessus.

Conclusions/Significance
This study shows that M. fortuitum group and M. abscessus were the most common NTM found in Java, Indonesia. The M. fortuitum group and M. abscessus were the most susceptible to amikacin; therefore, this was the empirical treatment of choice. The ability to form biofilms is directly proportional to the ability to adhere to and invade pneumocytes but not to the susceptibility profile or sliding motility characteristics.
Effectiveness of the Internet Attachment-Based Compassion Therapy (iABCT) to improve the quality of life and well-being in a population with chronic medical illness: A study protocol of a randomized controlled trial (SPIRIT compliant)
Authors: Martínez-Sanchis Marian , Vara Mª Dolores , Herrero Rocío , Campos Daniel , García-Campayo Javier , Baños Rosa Mª 
Published: December 2022

Background
Chronic medical illnesses significantly and negatively affect the quality of life of individuals who suffer them and represent one of the most important challenges faced by healthcare providers and policy-makers due to its rising prevalence and high rates of comorbidity. Compassion-based interventions delivered over the Internet may be a useful approach to facilitate illness management and improve the quality of life of individuals with chronic medical conditions.

Objectives
The purpose of this study is to describe a protocol for a randomized controlled trial to test the efficacy of the Internet Attachment-Based Compassion Therapy (iABCT) to improve the quality of life and well-being of patients with chronic medical illnesses.

Method
A two-arm, parallel-group, randomized controlled trial (RCT) will be carried out, with three assessment points (baseline, 3-month, and 6-month) under two conditions: intervention group and control group (waiting list). The primary outcomes include the quality of life on the EuroQol 5-Dimensions Questionnaire (EQ-5D) and the Pemberton Happiness Index (PHI). Secondary outcomes, such as compassion, self-care behaviors, illness interference, self-criticism, symptomatology, attachment styles, social support, and illness perception, will be considered. Moreover, an assessment on satisfaction and usability will be carried out. A total of 68 participants as minimum will be recruited (34 per arm). Intent-to-treat mixed-model analyses without any ad hoc imputations will be conducted.

Conclusions
Findings of this study will provide new insights into the potential of self-applied compassion-based interventions (CBI) delivered online in the context of chronic medical illnesses, considering aspects of their implementation (e.g., facilitators, barriers) and mechanisms of change.

Trial registration
The study is registered under Clinicaltrials.gov (NCT04809610) and it is currently in the participant recruitment phase.
Study protocol for connective tissue disease-associated interstitial lung disease trial (TEL-CTD-ILD): A randomized controlled trial of a home-based telemonitoring of treatment effects
Authors: Małysiak-Szpond Sylwia , Mozga Maria , Miądlikowska Ewa , Miłkowska-Dymanowska Joanna , Białas Adam Jerzy , Piotrowski Wojciech Jerzy 
Published: December 2022

Introduction
Interstitial lung disease is one of the most severe pulmonary complications related to connective tissue diseases, resulting in substantial morbidity and mortality. Telepneumology has the potential to improve the long-term management of patients with CTD-ILD. We propose a randomized controlled trial to evaluate the efficacy of home-based telemonitoring of patients with CTD-ILD, in whom treatment was initiated.

Materials and methods
We will conduct a randomized controlled trial comparing the standard of care with a telemonitoring program. Telemonitoring will start 10 to 14 days before treatment and will be carried out for three months of therapy. After initial training, patients from the intervention group will perform daily spirometry (FVC), transdermal pulse oximetry, pulse and blood pressure measurements, activity measurement (accelerometry), and assessment of the severity of cough and dyspnea. The results will be reported using a telemetric system designed by Mediguard® for this study. The primary outcome measure will be the health-related quality of life change using EQ-5D-5L questionnaire and St. George’s Respiratory Questionnaire, as measured at stationary visits in both study groups. Secondary outcomes will include assessment of lung function, costs of health service utilization, satisfaction from being telemonitored, dyspnea by mMRC, fatigue by FAS, patients’ adherence to recommended medications using the ASCD, anxiety and depression symptoms as measured by HADS, PHQ-9, and side effects of treatment.

Discussion
This is the first clinical trial protocol to evaluate home-based telemonitoring to optimize connective tissue disease-associated interstitial lung management. The study aims to provide data on the impact of telemonitoring on quality of life, evaluation of health status of patients with CTD-ILD using telemonitoring versus standard care. Additionally, we will evaluate the cost-effectiveness of telemonitoring solutions in patients with CTD-ILD.

Trial registration
ClinicalTrials.gov Identifier: NCT04428957; Registered June 11, 2020; https://clinicaltrials.gov/ct2/show/NCT04428957.
Parents’ intention to vaccinate their child for COVID-19: A mixed-methods study (CoVAccS–wave 3)
Authors: Smith Louise E. , Sherman Susan M. , Sim Julius , Amlôt Richard , Cutts Megan , Dasch Hannah , Sevdalis Nick , Rubin G. James 
Published: December 2022

Aim
To investigate UK parents’ vaccination intention at a time when COVID-19 vaccination was available to some children.

Methods
Data reported are from the second wave of a prospective cohort study. We conducted a mixed-methods study using an online survey of 270 UK parents (conducted 4–15 October 2021). At this time, vaccination was available to 16- and 17-year-olds and had become available to 12- to 15-year-olds two weeks prior. We asked participants whose child had not yet been vaccinated how likely they were to vaccinate their child for COVID-19. Linear regression analyses were used to investigate factors associated with intention (quantitative component). Parents were also asked for their main reasons behind vaccination intention. Open-ended responses were analysed using content analysis (qualitative component).

Results
Parental vaccination intention was mixed (likely: 39.3%, 95% CI 32.8%, 45.7%; uncertain: 33.9%, 95% CI 27.7%, 40.2%; unlikely: 26.8%, 95% CI 20.9%, 32.6%). Intention was associated with: parental COVID-19 vaccination status; greater perceived necessity and social norms regarding COVID-19 vaccination; greater COVID-19 threat appraisal; and lower vaccine safety and novelty concerns. In those who intended to vaccinate their child, the main reasons for doing so were to protect the child and others. In those who did not intend to vaccinate their child, the main reason was safety concerns.

Conclusions
Parent COVID-19 vaccination status and psychological factors explained a large percentage of the variance in vaccination intention for one’s child. Further study is needed to see whether parents’ intention to vaccinate their child is affected by fluctuating infection rates, more children being vaccinated, and the UK’s reliance on vaccination as a strategy to live with COVID-19.
Understanding clinician connections to inform efforts to promote high-quality inflammatory bowel disease care
Authors: Cohen-Mekelburg Shirley , Van Tony , Yu Xianshi , Costa Deena Kelly , Manojlovich Milisa , Saini Sameer , Gilmartin Heather , Admon Andrew J. , Resnicow Ken , Higgins Peter D. R. , Siwo Geoffrey , Zhu Ji , Waljee Akbar K. 
Published: December 2022

Background
Highly connected individuals disseminate information effectively within their social network. To apply this concept to inflammatory bowel disease (IBD) care and lay the foundation for network interventions to disseminate high-quality treatment, we assessed the need for improving the IBD practices of highly connected clinicians. We aimed to examine whether highly connected clinicians who treat IBD patients were more likely to provide high-quality treatment than less connected clinicians.

Methods
We used network analysis to examine connections among clinicians who shared patients with IBD in the Veterans Health Administration between 2015–2018. We created a network comprised of clinicians connected by shared patients. We quantified clinician connections using degree centrality (number of clinicians with whom a clinician shares patients), closeness centrality (reach via shared contacts to other clinicians), and betweenness centrality (degree to which a clinician connects clinicians not otherwise connected). Using weighted linear regression, we examined associations between each measure of connection and two IBD quality indicators: low prolonged steroids use, and high steroid-sparing therapy use.

Results
We identified 62,971 patients with IBD and linked them to 1,655 gastroenterologists and 7,852 primary care providers. Clinicians with more connections (degree) were more likely to exhibit high-quality treatment (less prolonged steroids beta -0.0268, 95%CI -0.0427, -0.0110, more steroid-sparing therapy beta 0.0967, 95%CI 0.0128, 0.1805). Clinicians who connect otherwise unconnected clinicians (betweenness) displayed more prolonged steroids use (beta 0.0003, 95%CI 0.0001, 0.0006). The presence of variation is more relevant than its magnitude.

Conclusions
Clinicians with a high number of connections provided more high-quality IBD treatments than less connected clinicians, and may be well-positioned for interventions to disseminate high-quality IBD care. However, clinicians who connect clinicians who are otherwise unconnected are more likely to display low-quality IBD treatment. Efforts to improve their quality are needed prior to leveraging their position to disseminate high-quality care.
Playfulness in Shakespearean Adaptations, Marina Gerzic and Aidan Norrie (eds) (2020)
Authors: Ely-Harper Kerreen 
Published: December 2022

Review of: Playfulness in Shakespearean Adaptations, Marina Gerzic and Aidan Norrie (eds) (2020)
Abingdon: Routledge, 270 pp.,
ISBN 978-0-36725-646-3, h/bk, AUD 273
ISBN 978-0-36750-464-9, p/bk, AUD 77.99
ISBN 978-0-42928-880-7, e-book, AUD 62.09
UPAYA MEWUJUDKAN DYNAMIC GOVERNANCE PADA PELAYANAN PUBLIK DI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN SIDOARJO
Authors: Alim Bimantara Nur 
Published: December 2022

Tujuan dari penelitian ini yaitu menggambarkan upaya untuk mewujudkan dynamic governance pada pelayanan publik di Dinas Kependudukan dan Pencatatan Sipil dengan memperhatikan elemen culture dan capabilities seperti thinking ahead, thinking again, dan thinking across. Beberapa permasalahan yang terjadi pada pelayanan tersebut berasal dari unsur internal seperti kemampuan organisasi dalam menyampaikan komunikasi dan merespon permohonan pelayanan, lalu unsur eksternal seperti jumlah masyarakat yang sangat banyak dalam mengakses pelayanan sehingga menjadi tidak teroragnisir. Catatan permasalahan ini menjadi kendala dalam upaya meningkatkan pelayanan sehingga perlu dilakukan analisa lebih jauh agar dapat menemukan solusi yang tepat karena Pemerintah sedang menghadapi ketidakpastian terkait kondisi di masa kini ataupun masa mendatang. Perhatian yang dapat ditekankan pada pemikiran dynamic governance yaitu Pemerintah perlu memikirkan tindakan yang relevan untuk menghadapi permasalahan yang dinamis. Pada penelitian ini menggunakan metode kualitatif dengan tipe penelitian deskriptif. Penelitian berlokasi di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Sidoarjo. Teknik pengumpulan data bersumber dari data primer berupa wawancara dan data sekunder berupa artikel ilmiah serta laporan resmi. Teknik analisis data yang digunakan dalam penelitian memiliki beberapa tahapan di antaranya reduksi data, penyajian data, dan menarik kesimpulan. Teknik uji keabsahan data menggunakan triangulasi sumber data. Berdasarkan hasil penelitian, budaya organisasi Dinas Kependudukan dan Pencatatan Sipil sudah memasuki proses yang baik untuk menghadapi perubahan lingkungan yang dinamis. Kemudian pengaruh dari able people dan agile processes sangat menentukan kapabilitas untuk menghadapi dinamika yang terjadi dalam pelayanan publik. Kurang meratanya kompetensi dan kurang banyaknya tenaga kerja menyebabkan gagasan thinking ahead belum dapat direncanakan dengan lebih matang. Elemen kapabilitas yang dapat dijalankan dengan baik yaitu thinking again dimana instansi selalu meninjau evaluasi kinerja pegawai dan menganalisa respon masyarakat terhadap kinerja organisasi. Selanjutnya, thinking across menjadi elemen kapabilitas yang juga telah dijalankan dengan baik dengan mempelajari keberhasilan daerah lain dalam menyelenggarakan mal pelayanan publik lalu mengadopsinya.