bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Path to Solving Robotic Differential Equations Using Quantum Computing
Authors: Gehlot Vinod P. , Balas Mark J. , Quadrelli Marco B. , Bandyopadhyay Saptarshi , Bayard David S. , Rahmani Amir 
Published: May 2023

Abstract
Quantum computing and quantum information science is a burgeoning engineering field at the cusp of solving challenging robotic applications. This paper introduces a hybrid (gate-based) quantum computing and classical computing architecture to solve the motion propagation problem for a robotic system. This paper presents the quantum-classical architecture for linear differential equations defined by two types of linear operators: unitary and non-unitary system matrices, thereby solving any linear ordinary differential equations. The ability to encode information using bits or qubits—is essential in any computation problem. The results in this paper also introduce two novel approaches to encoding any arbitrary state vector or any arbitrary linear operator using qubits. Unlike other algorithms that solve ordinary differential equations (ODEs) using purely quantum or classical architectures, the ODE solver presented in this paper leverages the best of quantum and classical computing paradigms.
Subsequent Jumping Increases the Knee and Hip Abduction Moment, Trunk Lateral Tilt, and Trunk Rotation Motion During Single-Leg Landing in Female Individuals
Authors: Chijimatsu Masato , Ishida Tomoya , Yamanaka Masanori , Taniguchi Shohei , Ueno Ryo , Ikuta Ryohei , Samukawa Mina , Ino Takumi , Kasahara Satoshi , Tohyama Harukazu 
Published: May 2023

Single-leg landings with or without subsequent jumping are frequently used to evaluate landing biomechanics. The purpose of this study was to investigate the effects of subsequent jumping on the external knee abduction moment and trunk and hip biomechanics during single-leg landing. Thirty young adult female participants performed a single-leg drop vertical jumping (SDVJ; landing with subsequent jumping) and single-leg drop landing (SDL; landing without subsequent jumping). Trunk, hip, and knee biomechanics were evaluated using a 3-dimensional motion analysis system. The peak knee abduction moment was significantly larger during SDVJ than during SDL (SDVJ 0.08 [0.10] N·m·kg−1·m−1, SDL 0.05 [0.10] N·m·kg−1·m−1, P = .002). The trunk lateral tilt and rotation angles toward the support-leg side and external hip abduction moment were significantly larger during SDVJ than during SDL (P < .05). The difference in the peak hip abduction moment between SDVJ and SDL predicted the difference in the peak knee abduction moment (P = .003, R2 = .252). Landing tasks with subsequent jumping would have advantages for evaluating trunk and hip control as well as knee abduction moment. In particular, evaluating hip abduction moment may be important because of its association with the knee abduction moment.
Childhood/adolescent Sydenham’s chorea in the UK and Ireland: a BPSU/CAPSS surveillance study
Authors: Wooding Eva Louise , Morton Michael John Stuart , Lim Ming , Mitrofan Oana , Mushet Nadine , Sie Adrian , Knight Brodie , Ford Tamsin , Newlove-Delgado Tamsin 
Published: May 2023

ObjectiveTo conduct the first prospective surveillance study of Sydenham’s chorea (SC) in the UK and Ireland, and to describe the current paediatric and child psychiatric service-related incidence, presentation and management of SC in children and young people aged 0–16 years.DesignSurveillance study of first presentations of SC reported by paediatricians via the British Paediatric Surveillance Unit (BPSU) and all presentations of SC reported by child and adolescent psychiatrists through the Child and Adolescent Psychiatry Surveillance System (CAPSS).ResultsOver 24 months from November 2018, 72 reports were made via BPSU, of which 43 met the surveillance case definition of being eligible cases of suspected or confirmed SC. This translates to an estimated paediatric service-related incidence rate of new SC cases of 0.16 per 100 000 children aged 0–16 per year in the UK. No reports were made via CAPSS over the 18-month reporting period, although over 75% of BPSU cases presented with emotional and/or behavioural symptoms. Almost all cases were prescribed courses of antibiotics of varying duration, and around a quarter of cases (22%) received immunomodulatory treatment.ConclusionsSC remains a rare condition in the UK and Ireland but has not disappeared. Our findings emphasise the impact that the condition can have on children’s functioning and confirm that paediatricians and child psychiatrists should remain vigilant to its presenting features, which commonly include emotional and behavioural symptoms. There is a further need for development of consensus around identification, diagnosis and management across child health settings.
Changes in the epidemiological profile of SARS-CoV-2-positive individuals in Mexico across pandemic waves as an explanation of fatality reduction: a retrospective observational study
Authors: Gutierrez Juan Pablo , López Daniel , Ascencio Iván , Juárez Arturo , Olaiz Gustavo , Bertozzi Stefano M. 
Published: May 2023

ObjectivesWe aim to quantify shifts in hospitalisation and mortality and how those were related to the first three phases of the epidemic and individuals’ demographics and health profile among those with a positive test for SARS-CoV-2 treated at the Mexican Social Security Institute’s facilities from March 2020 to October 2021.DesignRetrospective observational study using interrupted time series analysis to identify changes in hospitalisation rate and case fatality rate (CFR) by epidemic wave.SettingData from the Mexican Institute of Social Security’s (IMSS) Online Influenza Epidemiological Surveillance System (SINOLAVE) that include all individuals that sought care at IMSS facilities all over Mexico.ParticipantsAll individuals included in the SINOLAVE with a positive PCR or rapid test for SARS-CoV-2.Primary and secondary outcome measuresMonthly test positivity rates, hospitalisation rates, CFRs and prevalence of relevant comorbidities by age group.ResultsFrom March 2020 to October 2021, the CFR declined between 1% and 3.5%; the declines were significant for those 0–9, 20–29, 30–39, 40–49 and 70 and older. The decline was steep during the first wave and was less steep or was temporarily reversed at the beginning of the second and third waves (changes in the trend of about 0.3% and 3.8%, and between 0.7% and 3.8%, respectively, for some age groups), but then continued to the end of the analytical period. Prevalence of diabetes, hypertension and obesity among patients testing positive also declined—two for most age groups (reductions of up to 10 percentage points for diabetes, 12 percentage points for hypertension and 19 percentage points for obesity).ConclusionData suggest that the decrease in COVID-19 fatality rate is at least partially explained by a change in the profile of those contracting the disease, that is, a falling proportion of individuals with comorbidities across all age groups.
Investigating the characteristics and correlates of systemic inflammation after traumatic brain injury: the TBI-BraINFLAMM study
Authors: Li Lucia M , Heslegrave Amanda , Soreq Eyal , Nattino Giovanni , Rosnati Margherita , Garbero Elena , Zimmerman Karl A , Graham Neil S N , Moro Federico , Novelli Deborah , Gradisek Primoz , Magnoni Sandra , Glocker Ben , Zetterberg Henrik , Bertolini Guido , Sharp David J 
Published: May 2023

IntroductionA significant environmental risk factor for neurodegenerative disease is traumatic brain injury (TBI). However, it is not clear how TBI results in ongoing chronic neurodegeneration. Animal studies show that systemic inflammation is signalled to the brain. This can result in sustained and aggressive microglial activation, which in turn is associated with widespread neurodegeneration. We aim to evaluate systemic inflammation as a mediator of ongoing neurodegeneration after TBI.Methods and analysisTBI-braINFLAMM will combine data already collected from two large prospective TBI studies. The CREACTIVE study, a broad consortium which enrolled >8000 patients with TBI to have CT scans and blood samples in the hyperacute period, has data available from 854 patients. The BIO-AX-TBI study recruited 311 patients to have acute CT scans, longitudinal blood samples and longitudinal MRI brain scans. The BIO-AX-TBI study also has data from 102 healthy and 24 non-TBI trauma controls, comprising blood samples (both control groups) and MRI scans (healthy controls only). All blood samples from BIO-AX-TBI and CREACTIVE have already been tested for neuronal injury markers (GFAP, tau and NfL), and CREACTIVE blood samples have been tested for inflammatory cytokines. We will additionally test inflammatory cytokine levels from the already collected longitudinal blood samples in the BIO-AX-TBI study, as well as matched microdialysate and blood samples taken during the acute period from a subgroup of patients with TBI (n=18).We will use this unique dataset to characterise post-TBI systemic inflammation, and its relationships with injury severity and ongoing neurodegeneration.Ethics and disseminationEthical approval for this study has been granted by the London—Camberwell St Giles Research Ethics Committee (17/LO/2066). Results will be submitted for publication in peer-review journals, presented at conferences and inform the design of larger observational and experimental medicine studies assessing the role and management of post-TBI systemic inflammation.
Ureteropelvic junction obstruction with primary lymphoedema associated withCELSR1variants
Authors: Alpaslan Murat , Mestré-Godin Sandrine , Lay Aurélie , Giacalone Guido , Helaers Raphaël , Adham Salma , Kovacsik Hélène , Guillemard Sophie , Mercier Erick , Boon Laurence , Revencu Nicole , Brouillard Pascal , Quere Isabelle , Vikkula Miikka 
Published: May 2023

BackgroundPrimary lymphoedema (PL) is a chronic, debilitating disease caused by developmental and functional defects of the lymphatic system. It is marked by an accumulation of interstitial fluid, fat and tissue fibrosis. There is no cure. More than 50 genes and genetic loci have been linked to PL. We sought to study systematically cell polarity signalling proteinCadherin Epidermal Growth Factor Laminin G Seven-pass G-type Receptor 1(CELSR1) variants linked to PL.MethodsWe investigated 742 index patients from our PL cohort using exome sequencing.ResultsWe identified nine variants predicted to causeCELSR1loss of function. Four of them were tested for nonsense-mediated mRNA decay, but none was observed. Most of the truncated CELSR1 proteins would lack the transmembrane domain, if produced. The affected individuals had puberty/late-onset PL on lower extremities. The variants had a statistically significant difference in penetrance between female patients (87%) and male patients (20%). Eight variant carriers had a kidney anomaly, mostly in the form of ureteropelvic junction obstruction, which has not been associated withCELSR1before.CELSR1is located in the 22q13.3 deletion locus of the Phelan-McDermid syndrome. As variable renal defects are often seen in patients with the Phelan-McDermid syndrome,CELSR1may be the long-sought gene for the renal defects.ConclusionPL associated with a renal anomaly suggests aCELSR1-related cause.
HnRNPR strongly represses splicing of a critical exon associated with spinal muscular atrophy through binding to an exonic AU-rich element
Authors: Jiang Tao , Qu Ruobing , Liu Xuan , Hou Yanjun , Wang Li , Hua Yimin 
Published: May 2023

BackgroundSpinal muscular atrophy (SMA) is a motor neuron disease caused by mutations of survival of motor neuron 1(SMN1) gene, which encodes the SMN protein.SMN2, a nearly identical copy ofSMN1, with several single-nucleotide substitutions leading to predominant skipping of its exon 7, is insufficient to compensate for loss ofSMN1. Heterogeneous nuclear ribonucleoprotein R (hnRNPR) has been previously shown to interact with SMN in the 7SK complex in motoneuron axons and is implicated in the pathogenesis of SMA. Here, we show that hnRNPR also interacts withSMN1/2pre-mRNAs and potently inhibits exon 7 inclusion.MethodsIn this study, to examine the mechanism that hnRNPR regulatesSMN1/2splicing, deletion analysis in anSMN2minigene system, RNA-affinity chromatography, co-overexpression analysis and tethering assay were performed. We screened antisense oligonucleotides (ASOs) in a minigene system and identified a few that markedly promotedSMN2exon 7 splicing.ResultsWe pinpointed an AU-rich element located towards the 3′ end of the exon that mediates splicing repression by hnRNPR. We uncovered that both hnRNPR and Sam68 bind to the element in a competitive manner, and the inhibitory effect of hnRNPR is much stronger than Sam68. Moreover, we found that, among the four hnRNPR splicing isoforms, the exon 5-skipped one has the minimal inhibitory effect, and ASOs inducinghnRNPRexon 5 skipping also promoteSMN2exon 7 inclusion.ConclusionWe identified a novel mechanism that contributes to mis-splicing ofSMN2exon 7.
Genotype–phenotype correlation and treatment effects in young patients withGNAO1-associated disorders
Authors: Thiel Moritz , Bamborschke Daniel , Janzarik Wibke G. , Assmann Birgit , Zittel Simone , Patzer Steffi , Auhuber Andrea , Opp Joachim , Matzker Eva , Bevot Andrea , Seeger Juergen , van Baalen Andreas , Stüve Burkhard , Brockmann Knut , Cirak Sebahattin , Koy Anne 
Published: May 2023

BackgroundPatients carrying pathogenic variants inGNAO1often present with early-onset central hypotonia and global developmental delay, with or without epilepsy. As the disorder progresses, a complex hypertonic and hyperkinetic movement disorder is a common phenotype. A genotype–phenotype correlation has not yet been described and there are no evidence-based therapeutic recommendations.MethodsTo improve understanding of the clinical course and pathophysiology of this ultra-rare disorder, we built up a registry forGNAO1patients in Germany. In this retrospective, multicentre cohort study, we collected detailed clinical data, treatment effects and genetic data for 25 affected patients.ResultsThe main clinical features were symptom onset within the first months of life, with central hypotonia or seizures. Within the first year of life, nearly all patients developed a movement disorder comprising dystonia (84%) and choreoathetosis (52%). Twelve (48%) patients suffered life-threatening hyperkinetic crises. Fifteen (60%) patients had epilepsy with poor treatment response. Two patients showed an atypical phenotype and seven novel pathogenic variants inGNAO1were identified. Nine (38%) patients were treated with bilateral deep brain stimulation of the globus pallidus internus. Deep brain stimulation reduced hyperkinetic symptoms and prevented further hyperkinetic crises. The in silico prediction programmes did not predict the phenotype by the genotype.ConclusionThe broad clinical spectrum and genetic findings expand the phenotypical spectrum ofGNAO1-associated disorder and therefore disprove the assumption that there are only two main phenotypes. No specific overall genotype–phenotype correlation was identified. We highlight deep brain stimulation as a useful treatment option in this disorder.
Understanding bud rot development, caused by Botrytis cinerea, on cannabis (Cannabis sativa L.) plants grown under greenhouse conditions
Authors: Mahmoud Mohannad , BenRejeb Ines , Punja Zamir K. , Buirs Liam , Jabaji Suha 
Published: May 2023

Botrytis cinerea is a widespread necrotrophic plant pathogen that causes diseases on >1000 plant species, including vegetables and ornamental greenhouse crops. On cannabis ( Cannabis sativ a L.), the pathogen is responsible for causing “bud rot”, a major disease affecting the inflorescences (compound flowers), as well as seedling damping-off and leaf blight under certain conditions. During greenhouse cultivation, Botrytis cinerea can destroy cannabis inflorescences rapidly under optimal relative humidity conditions (>70%) and moderate temperatures (17–24 °C). Little is currently known about the host–pathogen interactions of Botrytis cinerea on cannabis. Information gleaned from other hosts can provide valuable insights for comparative purposes to understand disease development, epidemiology, and pathogenicity of Botrytis cinerea on cannabis crops. This review describes the pathogenesis and host responses to Botrytis infection and assesses potential mechanisms involved in disease resistance. The effects of microclimatic and other environmental conditions on disease development, strategies for early disease detection using prediction models, and the application of biological control agents that can prevent Botrytis cinerea development on cannabis are discussed. Other potential disease management approaches to reduce the impact of Botrytis bud rot are also reviewed. Numerous opportunities for conducting additional research to better understand the cannabis– Botrytis cinerea interaction are identified.
Protective effects of diclofenac on liver graft preservation
Authors: Chaabani Roua , Bejaoui Mohamed , Zaouali Mohamed Amine , Ben Abdennebi Hassen 
Published: May 2023

This study aims to evaluate the effect of diclofenac addition to the preservation solution Celsior on liver graft preservation. Liver from Wistar rats were cold flushed in situ, harvested, and then stored in Celsior solution (24 h, 4 °C) supplemented or not with 50 mg/L of diclofenac sodium salt. Reperfusion was performed (120 min, 37 °C) using the isolated perfusion rat liver model. Perfusate samples were collected to evaluate transaminases’ activities after cold storage and by the end of reperfusion. To evaluate liver function, bile flow, hepatic clearance of bromosulfophthalein, and vascular resistance were assessed. Diclofenac scavenging property (DPPH assay) as well as oxidative stress parameters (SOD and MPO activities and the concentration of glutathione, conjugated dienes, MDA, and carbonylated proteins) were measured. Transcription factors (PPAR-γ and NF-κB), inflammation (COX-2, IL-6, HMGB-1, and TLR-4), as well as apoptosis markers (Bcl-2 and Bax) were determined by quantitative RT-PCR. Enriching the preservation solution Celsior with diclofenac sodium salt attenuated liver injuries and improved graft function. Oxidative stress, inflammation, and apoptosis were significantly reduced in Celsior + Diclo solution. Also, diclofenac activated PPAR-γ and inhibited NF-κB transcription factors. To decrease graft damage and improve transplant recovery, diclofenac sodium salt may be a promising additive to preservation solution.
Viscous attenuation of gravitational waves propagating through an inhomogeneous background
Authors: Pandey Shashank Shekhar , Sarkar Arnab , Ali Amna , Majumdar Archan S. 
Published: May 2023

AbstractWe consider the propagation of gravitational waves in the late-time Universe in the presence of matter distribution inhomogeneities, and we also consider the cosmic fluid to be viscous. In this work, we investigate the cumulative effect of inhomogeneities and viscosity of the cosmic-fluid on the observables associated with the sources of the gravitational waves. Employing Buchert’s averaging procedure in the backreaction framework, we consider a model of spacetime in which matter is distributed in-homogeneously across space. Using the modified redshift versus distance relation, through the averaging process in the context of the model, we study the variation of the redshift-dependent part of the observed gravitational wave amplitude for different combinations of our model parameters while simultaneously considering damping of the gravitational wave amplitude due to viscosity of the cosmic-fluid. Then, we investigate the differences occurring in the variation of the redshift-dependent part of the observed gravitational wave amplitude due to consideration of viscous attenuation. We show that there are significant deviations after the inclusion of viscous attenuation in our analysis, depending on the chosen value of the coefficient of viscosity. Our result signifies the importance of the effect of viscosity, within the model of an inhomogeneous Universe, on precision measurements of parameters of compact-binary sources of gravitational waves.
Genus expansion of matrix models and $$\hbar $$ expansion of BKP hierarchy
Authors: Drachov Yaroslav , Zhabin Aleksandr 
Published: May 2023

AbstractWe continue the investigation of the connection between the genus expansion of matrix models and the $$\hbar $$
ħ
expansion of integrable hierarchies. In this paper, we focus on the BKP hierarchy, which corresponds to the infinite-dimensional Lie algebra of type B. We consider the genus expansion of such important solutions as Brézin–Gross–Witten (BGW) model, Kontsevich model, and generating functions for spin Hurwitz numbers with completed cycles. We show that these partition functions with inserted parameter $$\hbar $$
ħ
, which controls the genus expansion, are solutions of the $$\hbar $$
ħ
-BKP hierarchy with good quasi-classical behavior. $$\hbar $$
ħ
-BKP language implies the algorithmic prescription for $$\hbar $$
ħ
-deformation of the mentioned models in terms of hypergeometric BKP $$\tau $$
τ
-functions and gives insight into the similarities and differences between the models. Firstly, the insertion of $$\hbar $$
ħ
into the Kontsevich model is similar to the one in the BGW model, though the Kontsevich model seems to be a very specific example of hypergeometric $$\tau $$
τ
-function. Secondly, generating functions for spin Hurwitz numbers appear to possess a different prescription for genus expansion. This property of spin Hurwitz numbers is not the unique feature of BKP: already in the KP hierarchy, one can observe that generating functions for ordinary Hurwitz numbers with completed cycles are deformed differently from the standard matrix model examples.
Possible molecular dibaryons with csssqq quarks and their baryon–antibaryon partners
Authors: Kong Shu-Yi , Zhu Jun-Tao , He Jun 
Published: May 2023

AbstractIn this work, we systematically investigate the charmed–strange dibaryon systems with csssqq quarks and their baryon–antibaryon partners from the interactions $$\varXi ^{(',*)}_{c}\varXi ^{(*)}$$

Ξ
c

(
′

,

∗
)

Ξ

(

∗
)

, $$\varOmega ^{(*)}_c\varLambda $$

Ω
c

(

∗
)

Λ

, $$\varOmega ^{(*)}_c\varSigma ^{(*)}$$

Ω
c

(

∗
)

Σ

(

∗
)

, $$\varLambda _c\varOmega $$

Λ
c

Ω

and $$\varSigma ^{(*)}_c\varOmega $$

Σ
c

(

∗
)

Ω

and their baryon–antibaryon partners from interactions $$\varXi ^{(',*)}_{c}\bar{\varXi }^{(*)}$$

Ξ
c

(
′

,

∗
)

Ξ

¯

(

∗
)

, $$\varOmega ^{(*)}_c\bar{\varLambda }$$

Ω
c

(

∗
)

Λ

¯

, $$\varOmega ^{(*)}_c\bar{\varSigma }^{(*)}$$

Ω
c

(

∗
)

Σ

¯

(

∗
)

, $$\varLambda _c\bar{\varOmega }$$

Λ
c

Ω

¯

and $$\varSigma ^{(*)}_c\bar{\varOmega }$$

Σ
c

(

∗
)

Ω

¯

. The potential kernels are constructed with the help of effective Lagrangians under SU(3), heavy quark, and chiral symmetries to describe these interactions. To search for possible molecular states, the kernels are inserted into the quasipotential Bethe–Salpeter equation, which is solved to find poles from scattering amplitude. The results suggest that 36 and 24 bound states can be found in the baryon–baryon and baryon–antibaryon interactions, respectively. However, much large values of parameter $$\alpha $$
α
are required to produce the bound states from the baryon–antibaryon interactions, which questions the existence of these bound states. Possible coupled-channel effect are considered in the current work to estimate the couplings of the molecular states to the channels considered.