bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular endothelial growth factor expression and significance in different grades of the Breast Imaging Reporting and Data System*
Authors: Wang Gangping , Li Jingjing , Yang Shuguang , Zhang Zuofeng , Lei Songjing 
Published: June 2023

AbstractObjectiveMammography is the only modality proven to reduce mortality in breast cancer, and ultrasonography is a well-known adjunct to mammography screening. The Breast Imaging Reporting and Data System (BI-RADS) classification is a practical tool and is correlated with histopathology and combined use with triple assessment (examination, imaging, and biopsy) of palpable diagnostic cases. This study aimed to investigate the relationship between vascular endothelial growth factor (VEGF) expression and different grades of BI-RADS in breast cancer.MethodsNinety-six patients with breast carcinoma were evaluated using BI-RADS by ultrasonography, mammography, and a combination of both modalities. In the combined imaging assessment, BI-RADS 1-4a grade was considered when the score of ultrasonography and mammography was lower than 4a, and BI-RADS 4b-5a grade was considered when the score of ultrasonography and mammography was higher than 4a. Immunohistochemical Ultra SensitiveTMS-P method was employed to evaluate the expression of VEGF in 96 patients. Fifty patients with benign breast disease were selected as the control group. The relationship between VEGF expression and different grades of BI-RADS and that between VEGF expression and other standard prognostic parameters associated with invasive breast cancer, such as size, grade, cancer stage, and metastasis were analyzed.ResultsThe sensitivities of ultrasonography and mammography alone was 74.0% and 84.4%, respectively; However, the sensitivity of their combination increased to 90.6%. The positive rates of VEGF in invasive breast cancer BI-RADS 4b-5 (59/87, 67.8%) were higher than those in BI-RADS 4a (3/9, 33.3%,P< 0.05) and benign breast disease tissues (BI-RADS 1-4a, 11/50, 22.0%) (P< 0.05). There was a positive correlation between VEGF overexpression and BI-RADS 4b-5, histological grade (III), lymph node metastasis, and distant metastasis of invasive breast cancer. VEGF expression was not related to the age and size of the tumor in each group (P> 0.05).ConclusionThere was a positive correlation between VEGF overexpression and BI-RADS 4b-5 grade. The overexpression of VEGF might be an important biological marker for the invasion and metastasis of breast cancer.
Association between diabetes mellitus, hypertension, hyperlipidemia, chronic viral hepatitis, and the risk of multiple myeloma: a case-control study
Authors: Zhou Gang , Meng Xiangyu , Liu Shangqin 
Published: June 2023

AbstractObjectiveThis case-control study aimed to investigate whether diabetes mellitus (DM), hypertension, hyperlipidemia, and chronic viral hepatitis are risk factors for multiple myeloma (MM). Moreover, the clinical characteristics of MM patients with or without the abovementioned exposure factors were analyzed.MethodsIn total, 340 MM patients and 680 patients with benign diseases who were hospitalized from January 2012 to December 2017 were classified under the case group and control group, respectively. Data about medical history of DM, hypertension, hyperlipidemia and chronic viral hepatitis were collected by reviewing medical records. Univariate and multivariate analyses were conducted to compare the history of DM, hypertension, hyperlipidemia, and viral hepatitis between the two groups. Considering DM, hypertension, hyperlipidemia, and chronic viral hepatitis as exposure factors, clinical characteristics, such as renal function and presence of fungal and other types of infections, between the exposed and non-exposed groups were analyzed.ResultsNo significant difference was observed in the prevalence of DM, hypertension, and hyperlipidemia between the case and control groups. MM patients had a higher prevalence of chronic viral hepatitis than those with benign diseases. No significant difference was observed in the prevalence of renal dysfunction, fungal infection, and non-fungal infections in MM patients with or without DM, hypertension, and hyperlipidemia. MM patients with chronic viral hepatitis had a significantly higher prevalence of non-fungal infections during hospitalization than those without.ConclusionNo significant association was noted between MM and DM, hypertension, and hyperlipidemia. Chronic viral hepatitis is correlated to a significantly higher risk of MM, and MM patients with chronic viral hepatitis were more susceptible to non-fungal infections during hospitalization. Although a non-significant trend was observed in this study, we believe that DM and hypertension might be associated with a higher risk of MM. Thus, large-scale studies must be conducted to validate the results of the current study.
Clinical characteristics and survival outcomes of perianal Paget's disease: A SEER population-based study*
Authors: Peng Hui , Liu Zhimin , Ara Ghoorun Roshan , Yuan Xianglin 
Published: June 2023

Abstract

Objective
The aim of the study was to analyze the clinical features of patients with perianal Paget's disease (PPD) and investigate prognosis risk factors.

Methods
The SEER*Stat software was used to identify 116 PPD patients from 1975 to 2015 in the SEER research database. The Kaplan-Meier method was used to conduct a univariate analysis for PPD patients. The differences in survival rates were evaluated using the log-rank test. The differences in the clinicopathological features of PPD patients with or without anorectal carcinoma were compared using the chi-square test.

Results
The median survival time of PPD patients was 44 months. The median age of onset was 73 years old. The 43.10% of the patients were alive at the end of follow up, and only 12.93% of the patients died of PPD. Elderly (age > 70 years; χ2 = 9.453, P = 0.002), poor differentiation (χ2 = 46.557, P = 0.000) and abdominal perineal resection (APR; χ2 = 46.557, P = 0.000) were unfavorable risk factors of prognosis. Nearly 50% of PPD had combined with other malignancies, and over 22.41% of those had multiple primary neoplasms (3 or more). PPDs predisposed concurrent malignancy, and 48.21% of PPD patients with other malignancies combined with anorectal carcinoma in the study. Stage (χ2 = 10.127, P = 0.018), and surgical method (χ2 = 12.245, P = 0.007) were statistically significant in the PPD patients with or without anorectal carcinoma. The 16.07% of patients had multiple lesions of Paget's.

Conclusion
Patients with PPD have a favorable survival, while the disease-specific mortality is low. Diagnosed age, differentiation, and surgical methods were the influence factors of prognosis in PPD patients. PPDs with anorectal carcinoma is of most important in further investigation.
Identification of potential immune-related prognostic biomarkers of lung cancer using gene co-expression network analysis*
Authors: Chen Aixia , Zhao Shengnan , Zhou Fei , Lv Hongying , Liang Donghai , Jiang Tao , Liu Rui , Zhu Lijin , Cao Jingyu , Liu Shihai , Yu Hongsheng 
Published: June 2023

AbstractObjectiveThe objective of this study was to identify new carcinogenetic hub genes and develop the integration of differentially expressed genes to predict the prognosis of lung cancer.MethodsGSE139032 microarray data packages were downloaded from the Gene Expression Omnibus for planning, testing, and review of data. We identified KRT6C, LAMC2, LAMB3, KRT6A, and MYEOV from a key module for validation.ResultsWe found that the five genes were related to a poor prognosis, and the expression levels of these genes were associated with tumor stage. Furthermore, Kaplan-Meier plotter showed that the five hub genes had better prognostic values. The mean levels of methylation in lung adenocarcinoma (LUAD) were significantly lower than those in healthy lung tissues for the hub genes. However, gene set enrichment analysis (GSEA) for single hub genes showed that all of them were immune-related.ConclusionOur findings demonstrated that KRT6C, LAMC2, LAMB3, KRT6A, and MYEOV are all candidate diagnostic and prognostic biomarkers for LUAD. They may have clinical implications in LUAD patients not only for the improvement of risk stratification but also for therapeutic decisions and prognosis prediction.Abbreviations:LUAD, lung adenocarcinoma; GSEA, gene set enrichment analysis; NSCLC, non-small-cell lung cancer; WGCNA, weighted gene co-expression network analysis; MEs, module eigengenes; GS, gene significance; MS, module significance; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, gene ontology; CC, cellular component; MF, molecular function; BP, biological process; GEPIA, gene expression profiling interactive analysis; HPA, Human Protein Atlas; TIMER, Tumor Immune Estimation Resource; TCGA, The Cancer Genome Atlas; OS, overall survival; PF, first progression; PPS, post-progression survival; IHC, immunohistochemical
Analysis of the adverse reactions of atezolizumab: A real-world study based on FAERS database
Authors: Liu Hao , Zhang Yujing , Li Jingyi , Yan Rong 
Published: June 2023

AbstractObjectiveIn this study, we aimed to determine the incidence of adverse drug reactions (ADRs) of atezolizumab, identify ADR signals that are significantly related to atezolizumab, and provide a reference for the rational use of atezolizumab in the clinic through the statistical analysis of its adverse drug events (ADEs) reported in the American Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database.MethodsIn total, 4796 cases of atezolizumab ADEs reported in the American FAERS database from 2017 to 2019 were retrospectively analyzed.ResultsThe top three ADEs were febrile neutropenia (3.7%), anemia (2.9%), and acute renal failure (2.3%). In addition, the incidence rates of some ADEs were significantly different according to sex and age. The systematic organ classification of atezolizumab ADEs involved 32 systems, among which the top three were blood and lymphatic system disorders (585 cases, 12.2%), gastrointestinal disorders (433 cases, 9.0%), and infections and infestations (401 cases, 8.4%). The reporting odds ratio (ROR) method was used to detect the ADR signals of atezolizumab. The ROR (95% confidence interval) of the top ADE, febrile neutropenia, was 39.236 (33.757-45.604). In addition, we found 121 cases of complications associated with immune-related ADEs.ConclusionThe ADRs of atezolizumab reported in the FAERS database were consistent with those mentioned in the instructions for atezolizumab use, suggesting that atezolizumab has an acceptable and controllable drug effect.
Diagnostic value of lncRNAs as potential biomarkers for oral squamous cell carcinoma diagnosis: a meta-analysis*
Authors: Wei Yuxue , Yang Hua , Liu Xiaoqiu 
Published: June 2023

Abstract

Objective
Several studies have revealed the critical role of long non-coding RNAs (lncRNAs) as biomarkers for diagnosing oral squamous cell carcinoma (OSCC). However, the data remain inconsistent. This meta-analysis was performed to summarize the potential of lncRNAs as OSCC biomarkers.

Methods
We searched PubMed, Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases for literature published until December 10, 2020. Study quality was assessed using Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, and other measures regarding lncRNAs for OSCC diagnosis were pooled using bivariate meta-analysis models. Data analyses were performed using STATA 14.0.

Results
Overall, 8 studies with 981 cases and 585 controls were included in the pooled analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the receiver operating characteristic curve values were as follows: 0.76 [95% confidence interval (CI), 0.65-0.84], 0.90 (95% CI, 0.82-0.95), 7.5 (95% CI, 4.20-13.40), 0.27 (95% CI, 0.18-0.39), 28 (95% CI, 13.00-58.00), 0.90 (95% CI, 0.87-0.93), respectively. Deeks’ funnel plot asymmetry test (P = 0.56) indicated no potential publication bias.

Conclusion
Our meta-analytical evidence suggests that lncRNAs could be employed as a potential non-invasive diagnostic tool for OSCC.
Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer*
Authors: Wang Guangyu , Yin Sutong , Afrifa Justice , Rong Guihong , Jiang Shaofeng , Guo Haonan , Hou Xianliang 
Published: June 2023

Abstract

Objective

UBR5, recently identified as a potential target for cancer therapeutics, is overexpressed in multiple malignant tumors. In addition, it is closely associated with the growth, prognosis, metastasis, and treatment response of multiple types of cancer. Although emerging evidence supports the relationship between UBR5 and cancer, there are limited cancer analyses available.

Methods
In this study, online databases (TIMER2, GEPIA2, UALCAN, c-BioPortal, STRING) were employed to comprehensively explore expression levels and prognostic values of the UBR5 gene in cancer, using bioinformatic methods.

Results
We found that various characteristics of the UBR5 gene such as gene expression, survival value, genetic mutation, protein phosphorylation, immune infiltration, and pathway activities in the normal tissue were remarkably different from those in the primary tumor. Furthermore, “protein processing in spliceosome” and “ubiquitin mediated proteolysis” have provided evidence for their potential involvement in the development of cancer.

Conclusion
Our findings may provide insights for the selection of novel immunotherapeutic targets and prognostic biomarkers for cancer.
Comparison of conventional right colectomy and complete mesocolic excision technique—case–control analysis of short-term results
Authors: Sztipits Tamas , Mészáros Peter , Dubóczki Zsolt , Wettstein Daniel , Olah Gergely , Mezo Kornel , Budai Barna , Mersich Tamas 
Published: June 2023

Summary
Introduction
The long-term oncologic advantages of complete mesocolic excision (CME) with central vascular ligation and extended lymphadenectomy in right-sided colon cancer have been emphasized in several studies, without compromise of perioperative morbidity or mortality; however, prospective randomized data are scarce.

Methods
We performed a single-center non-randomized case–control study comparing conventional non-CME right colectomies (nCME) and complete mesocolic excision (CME) procedures during the period from January 2019 to December 2020. Perioperative morbidity, length of hospital stay (LOHS), operative time, and lymph node yield were analyzed.

Results
A total of 131 patients underwent surgery for right-sided colon cancer, with 28 (21%) in the CME group and 103 (79%) in the conventional group. Operative time was significantly longer in the CME group (p < 0.001) compared to conventional procedures. The duration of hospitalization was statistically similar (p = 0.226), no difference was observed in 30-day morbidity (p = 0.166), and the majority of complications in both groups were grades 0–2 (CME: 82%; nCME: 91%). There were no 30-day mortalities. The lymph node yield in CME was significantly higher compared to the conventional surgery (p = 0.041).

Conclusion
Complete mesocolic excision (CME) for right-sided colon cancer is safe without increasing complications or hospital stay, with an acceptable increase in operative time. The significant increase in lymph node yield enables better staging and may lead to improved long-term oncologic outcomes.
A content analysis of tobacco content in season 1 of ‘And Just Like That’
Authors: Barker Alexander B. , Bal Jaspreet , Murray Rachael L. 
Published: June 2023

Abstract
Aim
‘Sex and the City’ regularly featured smoking as a plot device, often linked with sexuality and female empowerment. Eighteen years later, the follow up ‘And Just Like That’ was released. The aim of this paper was to explore the amount of tobacco content in the first series of ‘And Just Like That’.

Subject and methods
A 1-minute content analysis of the 10 episodes from season 1 of ‘And Just Like That’.

Results
The 10 episodes included 394 one-minute intervals of content, with individual episodes ranging from 35–44 minutes. Tobacco content occurred in 45 intervals (11% of the total) across all 10 episodes.

Conclusion
This study demonstrates that, despite the 18-year age gap between the end of the ‘Sex and the City’ TV series and the start of ‘And Just Like That’, and the declining smoking rates during that time, tobacco content is still regularly featured in these programmes. Whilst viewing figures are not available for this series, we know that this was HBO Max’s most streamed show of all time and was highly popular; it is, therefore, likely that large numbers of people were exposed to tobacco content through this programme.
Can democracy accelerate sustainability transformations? Policy coherence for participatory co-existence
Authors: Pickering Jonathan 
Published: June 2023

AbstractThe 2030 Agenda envisages a world “in which democracy, good governance and the rule of law […] are essential for sustainable development” (Transforming our world: The 2030 Agenda for sustainable development, 2015, paragraph 9). However, the extent to which democratic practices can help or hinder sustainable development remains contested. I show how the relationship between democracy and environmental sustainability can be illuminated by recent advances in research on policy coherence for sustainable development. I apply a framework developed by Shawoo et al., (2022), to illustrate how (in)coherence between these two objectives is driven by a mix of ideas, institutions and interests. This framework can, in turn, help to identify policy options for strengthening coherence between democratic and environmental aims, spanning pluralisation of integrative frames and discourses, inclusive institutional design and reforms that broaden the range of public interests included in decision-making while restraining undue influence of vested interests.
Global Existence and Blow-up Solutions for a Parabolic Equation with Critical Nonlocal Interactions
Authors: Zhang Jian , Rădulescu Vicentiu D. , Yang Minbo , Zhou Jiazheng 
Published: June 2023

Abstract
In this paper, we study the initial boundary value problem for the nonlocal parabolic equation with the Hardy–Littlewood–Sobolev critical exponent on a bounded domain. We are concerned with the long time behaviors of solutions when the initial energy is low, critical or high. More precisely, by using the modified potential well method, we obtain global existence and blow-up of solutions when the initial energy is low or critical, and it is proved that the global solutions are classical. Moreover, we obtain an upper bound of blow-up time for

$$J_{\mu }(u_{0})<0$$

J
μ

(

u
0

)

<
0

and decay rate of

$$H^{1}_{0}$$

H
0
1

and

$$L^{2}$$

L
2

-norm of the global solutions. When the initial energy is high, we derive some sufficient conditions for global existence and blow-up of solutions. In addition, we are going to consider the asymptotic behavior of global solutions, which is similar to the Palais-Smale (PS for short) sequence of stationary equation.
Integrating business and market intelligence to expedite service responsiveness: evidence from Malaysia
Authors: Nawaz Muhammad , Hameed Waseem Ul , Bhatti M. Ishaq 
Published: June 2023

AbstractIn today’s business world, Malaysian postal and courier companies are rapidly growing due to recent Covid-19 but they face various challenges due to intense competition in the use of high-tech e-services. The paper examines the role of business and market intelligence in expediting service innovation and responsiveness in Malaysia, which is considered the business hub of Asia. Primary survey data were collected from the 93 managerial staff of postal and courier companies in Malaysia. We employed PLS-SEM methodology to test the relationship between the selected variables of interest. The results indicate that market intelligence and business intelligence are the major contributors to service innovation and service responsiveness. Moreover, the role of knowledge management is crucial in better utilization of external and internal knowledge. Finally, this study provides practical guidelines to practitioners and policymakers of postal and courier companies to devise viable strategies for efficiently realizing service innovation and service responsiveness to the best satisfaction of the end customers.
Towards a systemic entrepreneurship activity model
Authors: Dahle Yngve , Reuther Kevin , Steinert Martin , Supphellen Magne 
Published: June 2023

AbstractEntrepreneurship research would benefit from a mechanism gathering activity data from a large number of entrepreneurial initiatives. This paper starts by building on Zott and Amit’s activity system perspective to introduce a holistic activity model of entrepreneurship containing seven steps and 29 elements. This model has been used by 13,927 entrepreneurial projects between the years of 2015 to 2022. By applying a digital, non-participant observation method, this led to the development of a dataset containing information on 935,745 activities. We use three concrete research cases to exemplify how this model, method and dataset can be utilized for bringing research on entrepreneurial activities forward.
Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Authors: Juarez-Vignon Whaley Juan Jose , Afkhami Michelle , Onyshchenko Mykola , Massarelli Erminia , Sampath Sagus , Amini Arya , Bell Diana , Villaflor Victoria M. 
Published: June 2023

Opinion statementNasopharyngeal carcinoma (NPC) is distinct in its anatomic location and biology from other epithelial head and neck cancer (HNC). There are 3 WHO subtypes, which considers the presence of Epstein-Barr virus (EBV) and other histopathology features. Despite the survival benefit obtained from modern treatment modalities and techniques specifically in the local and locally advanced setting, a number of patients with this disease will recur and subsequently die of distant metastasis, locoregional relapse, or both. In the recurrent setting, the ideal therapy approach continues to be a topic of discussion and current recommendations are platinum-based combination chemotherapy. Phase III clinical trials which led to the approval of pembrolizumab or nivolumab for head and neck squamous cell carcinoma (HNSCC) specifically excluded NPC. No immune checkpoint inhibitor therapy, to date, has been approved by the FDA to treat NPC although the National Comprehensive Cancer Network (NCCN) recommendations do include use of these agents. Hence, this remains the major challenge for treatment options. Nasopharyngeal carcinoma is challenging as it is really 3 different diseases, and much research is required to determine best options and sequencing of those options. This article is going to address the data to date and discuss ongoing research in EBV + and EBV – inoperable recurrent/metastatic NPC patients.