bluuebunny/crossref_metadata_2025_split huggingface dataset:
ARL15 Gene Variant rs255758 Provides Susceptibility to Rheumatoid Arthritis in Northwest Indian Population
Authors: Sandhu Inder Mohan Singh , Singh Hemender , Kaur Simranpreet , Rai Ekta , Mahajan Anupama , Mohan Gurinder , Sharma Swarkar 
Published: January 2025

Introduction:
Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component. ARL15 gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case–control association study design.

Materials and Methods:
DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.

Results:
The variant was found to follow Hardy–Weinberg Equilibrium (P = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (P = 0.024) with C as a risk allele and increased risk in the recessive model (CC vs. CA + AA; P = 0.004).

Conclusion:
The present study corroborates the earlier findings on the role of ARL15 gene variant rs255758 in RA and further contributes to its genetic etiology.
The influence of clinical pharmacist-directed PDCA and DRG on the hospital’s antitumor treatments and safety management
Authors: Gong Ting , Deng Min , Lei Haibo , Wu Shiwei , Long Liang , Zou Yang , Liu Xiang 
Published: January 2025

Abstract

Background:
To assess the impact of the clinical pharmacist-directed PDCA+DRG approach on antitumor treatments and safety management within a hospital setting, specifically focusing on medical expenses, the utilization rate of restricted-level antitumor drugs, and the allocation of expenditure on antitumor drugs and adjunctive medications across different cancer types.

Methods:
The retrospective study involved a comparative analysis between a control group (n = 105) and a PDCA+DRG group (n = 102) across various cancer types. On the basis of the medical insurance policy, the control group received treatment according to the latest medical guidelines, while the PDCA+DRG group received treatment based on the clinical pharmacist-directed PDCA and DRG approach. Medical expenses, utilization rates of restricted-level antitumor drugs, rational prescription rate, and the allocation of expenditure on antitumor drugs and adjunctive medications were evaluated.

Results:
The implementation of the clinical pharmacist-directed PDCA+DRG approach led to a significant reduction in medical expenses across different cancer types. The implementation of PDCA+DRG approach could effectively improve the rational use of antitumor drugs in surgery department, while it had limited impact on promoting the rational prescription in internal medicine department. The utilization rate of restricted-level antitumor drugs did not show significant differences between the control and PDCA+DRG groups. However, there was a notable increase in the proportion of expenditure on antitumor drugs in the PDCA+DRG group compared to the control group. Additionally, the PDCA+DRG group had a significantly lower proportion of expenditure on adjunctive medications for antitumor drugs.

Conclusion:
The findings suggest that the implementation of the clinical pharmacist directed PDCA+DRG approach in antitumor treatments and safety management within a hospital setting can lead to significant reductions in medical expenses and effective improvement of the rational use of antitumor drugs. While no significant changes were observed in the utilization rate of restricted-level antitumor drugs, the allocation of expenditure showed a higher proportion directed towards antitumor drugs and a lower proportion towards adjunctive medications. These results indicate potential improvements of clinical pharmacist involved approach, especially in cost-efficiency and resource allocation, which can guide healthcare institutions in optimizing antitumor treatments.
Genotypical analysis of gastrointestinal stromal tumors using next-generation sequencing
Authors: Deshpande Trupti V. , Dorwal Pranav , Anikhindi Akshay A , Tiwari Nishant , Jain Dharmendar , Mehra Simmi , Vaid Ashok , Raina Vimarsh 
Published: January 2025

Abstract

Background:
To study the prevalence of genetic mutations in patients with gastrointestinal stromal tumors (GIST) using next-generation sequencing at a tertiary care center in northern India.

Methods:
We performed genotypic analysis of histologically and immunohistochemically diagnosed GIST using Ion AmpliSeq Cancer Hotspot Panel v2 to identify mutations on resected biopsy samples.

Results:
In our cohort of 41 patients, we observed a variety of genetic mutations. The corresponding prevalence for those mutations was Tumour Protein 53 (TP53) 90%, KIT Protooncogene receptor tyrosine kinase (KIT) 88%, Platelet Derived Growth Factor Receptor (PDGFRA) 78%, HRas Proto-oncogene (HRAS) 61%, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) 56%, Kristen rat sarcoma viral oncogene homolog (KRAS) 54%, NRas Proconcogene GTPase (NRAS) 20%, Cyclin-dependent kinase inhibitor 2A (CDKN2A) 15%, and B-Raf proto-oncogene (BRAF) 7%.

Conclusion:
GISTs host a variety of mutations that need to be further investigated for their interplay and overall effect on the Indian population so that we can tailor treatment for better prognosis. The incidence of GIST is rising worldwide. Advances in technology have made tailored theranostics a possibility in managing GIST. Detailed genetic presentation of GIST is still unclear. Next-generation sequencing has provided us with an excellent tool to prospectively analyze the genetic makeup of GIST and most of the tumors. The present study opens up a huge possibility for using molecular makers for risk stratification of GIST and for theranostics of such tumors.
A retrospective pilot study of hyperthermic intraperitoneal chemotherapy (HIPEC) using the closed CO2 recirculation system on peritoneal carcinomatosis
Authors: Karabay Onder , Serin Kürsat Rahmi , Hacım Nadir Adnan , Sen Fatma , Terzi Mustafa Cem 
Published: January 2025

Abstract

Background:
Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with a closed CO2 recirculation has been recently developed to amplify better distribution of chemotherapeutic drugs and adequate fluid circulation due to turbulent flow and increased intraabdominal pressure by CO2. In this study, we aimed to present clinicopathological features of patients with peritoneal carcinomatosis who underwent HIPEC with closed CO2 recirculation and the technical features of the technique.

Methods:
Twenty patients who underwent cytoreductive surgery for peritoneal carcinomatosis followed by the closed CO2 recirculation HIPEC between November 2018 and October 2019 were retrospectively analyzed. Demographic and clinical variables and treatment outcomes were recorded.

Results:
There were 11 (55%) female and nine (45%) male patients with a mean age of 57.6 ± 10.3 years. Colon and ovarian cancer was the primary diagnosis in 10 (50%) and 4 patients (20%), respectively. The median peritoneal carcinomatosis index score was 15 (2-35). Colectomy and peritonectomy were the most common operations. During the early postoperative period, rate of minor and major complications were seen in six (30%) and three patients (15%), respectively. Median length of hospital stay and follow-up period were 6 days (4–15 days) and 7.5 months (2–17 months), respectively. There were three nonsurgical complications (pulmonary embolism, renal failure, myocardial infarction) leading to mortality in three patients (15%) during the follow-up period.

Conclusions:
HIPEC with CO2 recirculation may be a safe and feasible approach that can be performed in patients with peritoneal carcinomatosis secondary to different types of cancer.
A comparative evaluation of colposcopy and biopsy in the diagnosis of oral pre-malignant lesions and conditions, and oral carcinoma - An in vivo study
Authors: Kanwar Santosh , Khanum Nishath , Mahesh M. S , Patil Archana , Khairunnisa  
Published: January 2025

Abstract

Background:
Early detection of premalignant lesions and conditions leads to timely intervention and prevention of serious consequences such as oral carcinoma, thereby improving the quality of care to the patients. The aim of our study was to determine the vascular patterns and compare the biopsy obtained by clinical examination and colposcopic criteria by histopathological examination.

Methods:
Sixty subjects with oral submucous fibrosis, leukoplakia, lichen planus, erythroplakia, and carcinoma of buccal mucosa were selected based on the inclusion and exclusion criteria set forth for the study. Following a thorough clinical examination of the lesion, Clinician A was asked to select an area from which a biopsy specimen was obtained. For colposcopic examination, 3% acetic acid was applied to the lesion for approximately 30 seconds, and based on the colposcopic criteria, the biopsy site was selected by Clinician B blind to the choice of biopsy site selected by Clinician A. Both specimens were subjected to histopathologic examination. A comparison of the histopathologic diagnosis obtained with clinical and colposcopic examinations was performed.

Results:
The vascular pattern by colposcopic examination revealed that the punctation pattern was more prevalent in oral submucous fibrosis and reticular lichen planus, whereas the mosaic pattern was more prevalent in leukoplakia, and the atypical pattern was seen in erosive lichen planus, erythroplakia, and oral carcinoma. We also observed a sensitivity of 98% and a specificity of 38% for colposcopic biopsy examination and a sensitivity of 93% and a specificity of 64% for clinical biopsy examination.

Conclusion:
This study shows that biopsy based on colposcopic examination is more sensitive than clinical biopsy examination. Colposcopic examination of the oral mucosa can be implemented to select an appropriate biopsy site.
Unicuspid unicommissural aortic valves: A surgical pathology analysis
Authors: Vaideeswar Pradeep 
Published: January 2025

ABSTRACT
The unicuspid unicommisural aortic valve is an uncommon congenital malformation that often manifests as stenosis with or without regurgitation in adults in their third to fifth decades of life. This report characterizes the morphological features of surgically excised unicuspid valves in adults with clinical correlation. Among the surgically excised aortic valves over a period of 10 years, the clinical data and morphological features of unicuspid aortic valves were analyzed. The patients were grouped by the type of valvular function. Pathological features noted were the shape of the orifice, the status of the commissure and raphe, presence of fibrous thickening, calcification, and other complications. Twenty-three UAVs, excised over a 10-year period, represented 4.16% of the excised diseased aortic valves. There was a male preponderance with a mean age of 47.7 years. Majority of the patients (22 cases) had moderate to severe stenosis with varying degrees of regurgitation, and the valvular disease had been clinically attributed to rheumatic heart disease, bicuspid aortic valve, or senile degenerative changes. Most of the valves (18) had been cut at their commissural regions, and 2 rudimentary commissures or raphes were seen in 21 valves. Cuspal fibrosis/calcification was often associated with complications like ulceration, hemorrhage, and bland vegetations. Aneurysm of the ascending aorta had been present in 1 patient. The unicuspid unicommisural aortic valve while rare is usually clinically classified with the more common, congenitally bicuspid aortic valve. Clinical or imaging diagnosis can be challenging since calcification may obscure the morphology creating difficulties in distinguishing such valves from other congenital or acquired valvular pathologies, especially in older patients. Often it is only the gross examination that leads to the differentiation as was our observation.
Locally finitely presented Grothendieck categories and the pure semisimplicity conjecture
Authors: Fazelpour Ziba , Nasr-Isfahani Alireza 
Published: January 2025

Abstract
In this paper, we investigate locally finitely presented pure semisimple (hereditary) Grothendieck categories. We show that every locally finitely presented pure semisimple (resp., hereditary) Grothendieck category

$\mathscr {A}$

is equivalent to the category of left modules over a left pure semisimple (resp., left hereditary) ring when

$\mathrm {Mod}(\mathrm {fp}(\mathscr {A}))$

is a QF-3 category, and every representable functor in

$\mathrm {Mod}(\mathrm {fp}(\mathscr {A}))$

has finitely generated essential socle. In fact, we show that there exists a bijection between Morita equivalence classes of left pure semisimple (resp., left hereditary) rings

$\Lambda $

and equivalence classes of locally finitely presented pure semisimple (resp., hereditary) Grothendieck categories

$\mathscr {A}$

that

$\mathrm {Mod}(\mathrm {fp}(\mathscr {A}))$

is a QF-3 category, and every representable functor in

$\mathrm {Mod}(\mathrm {fp}(\mathscr {A}))$

has finitely generated essential socle. To prove this result, we study left pure semisimple rings by using Auslander’s ideas. We show that there exists, up to equivalence, a bijection between the class of left pure semisimple rings and the class of rings with nice homological properties. These results extend the Auslander and Ringel–Tachikawa correspondence to the class of left pure semisimple rings. As a consequence, we give several equivalent statements to the pure semisimplicity conjecture.
Restricted sumsets in multiplicative subgroups
Authors: Yip Chi Hoi 
Published: January 2025

Abstract
We establish the restricted sumset analog of the celebrated conjecture of Sárközy on additive decompositions of the set of nonzero squares over a finite field. More precisely, we show that if

$q>13$

is an odd prime power, then the set of nonzero squares in

$\mathbb {F}_q$

cannot be written as a restricted sumset

$A \hat {+} A$

, extending a result of Shkredov. More generally, we study restricted sumsets in multiplicative subgroups over finite fields as well as restricted sumsets in perfect powers (over integers) motivated by a question of Erdős and Moser. We also prove an analog of van Lint–MacWilliams’ conjecture for restricted sumsets, which appears to be the first analogue of Erdős--Ko–Rado theorem in a family of Cayley sum graphs.
Asymptotics for crank of overpartitions
Authors: Liu Edward Y.S. , Zhang Helen W.J. , Zhong Ying 
Published: January 2025

Abstract
Let

$\overline {M}(a,c,n)$

denote the number of overpartitions of n with first residual crank congruent to a modulo c with

$c\geq 3$

being odd and

$0\leq a<c$

. The central objective of this paper is twofold: firstly, to establish an asymptotic formula for the crank of overpartitions; and secondly, to establish several inequalities concerning

$\overline {M}(a,c,n)$

that encompasses crank differences, positivity, and strict log-subadditivity.
Assessment of Special Education Service Delivery for Children with Physical and Health Impairment
Authors: Ndoh Ugochi Nnenna , Odiba Regina Ada , Adebisi Rufus Olanrewaju 
Published: January 2025

Proper implementation of special education service helps children with physical and health impairment in their academic performance. The purpose of this study therefore is to investigate the assessment of special education service delivery for children with physical and health impairment in Afijio local government, Oyo. The study adopted a descriptive survey design. The target population in this study was fifty respondents. The sample for the study was the same as the target population, as this number was manageable within the time available. The study was carried out in three different schools in Afijio Local Government Oyo State. The research instruments used for collecting data were mainly questionnaires. The data was analyzed using qualitative and quantitative methods. It was then presented in narrative passages and tables using simple percentage in analysis the demographic data and Mean and Standard Deviation for the responses. The findings indicated that special education service delivery plays a major role in the education of children with physical and health impairment Afijio local government, Oyo State. The study recommends that School, facilities and infrastructures for special needs students should be made available by the government and the NGO’s, stigmatisation of special needs children should be stopped and government should put in place laws that will prevent people from having negative attitude towards physically challenged children, accessibility and availability of special schools for special needs children should be made available in every cities, towns and villages across Oyo State, government should make provision to train teachers that can handle special needs children, the government, NGO’s and privilege individuals should try to support for special needs children in all ramifications.
Keistimewaan Metode Role-Playing untuk Siswa SMP di Kelas Pendidikan Agama Kristen
Authors: Sihotang Sarwedy , Yulianingsih Dwiati 
Published: January 2025

The purpose of this research is to find out that the role-playing method is a special method that is suitable for Christian religious education lessons. This method provides an attraction for junior high school students to like Christian religious education lessons. The subjects of this research were junior high school students from class VII to class IX, aged 13-15 years. The method used in this research is a qualitative method with a literature study approach. The following are the features of the role-playing method in Christian religious education lessons for junior high school students, namely: increasing learning concentration and making it easier for them to understand the material, fun, practicing skills or psychomotor training for junior high school students, instilling a good identity, as a place to train emotions or emotional control. AbstrakTujuan penelitian ini adalah untuk mengetahui bahwa metode role-playing adalah metode yang istimewa, yang sesuai untuk pelajaran pendidikan agama Kristen. Metode ini memberikan daya tarik bagi siswa SMP untuk menyukai pelajaran pendidikan agama Kristen. Subyek penelitian ini yaitu siswa SMP dari kelas VII sampai kelas IX, meliputi rentang usia 13-15 tahun. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif dengan pendekatan studi kepustakaan. Keistimewaan metode role-playing pada pelajaran pendidikan agama Kristen bagi siswa SMP mencakup: meningkatkan konsentrasi belajar dan memudahkan mereka memahami materi, menyenangkan, melatih keterampilan atau melatih psikomotorik siswa SMP, menanamkan jati diri yang baik, sebagai wadah melatih emosi atau kontrol emosi.
Membumikan Nilai dan Etika Politik Kristen dalam Teologi Titus 3:1-7 Bagi Politikus Kristen Masa Kini
Authors: Ngesthi Yonathan Salmon Efrayim , Arifianto Yonatan Alex , Indriana Nining 
Published: January 2025

Many people of God feel reluctant or unwilling to discuss political ethics. Moreover, when Christians talk about politics, they will unilaterally stay away from it. Because there is an assumption that Christianity should not be mixed with politics. Through this research, Christian politicians who are involved in politics can ground the values and ethics of Christian politics in the theology of Titus 3:1-7 for today's Christian politicians as a basis for building healthy political theological ethics. Using a descriptive qualitative method with a literature study approach, it can be concluded that grounding Christian political values and ethics in the theology of Titus 3:1-7 for today's Christian politicians requires an understanding and paradigm that Christian politicians can know the nature of politics and its interests. They can even understand the church and political challenges. So that politicians who live with integrity have attitudes and principles that are in accordance with Christian political values and ethics. Of course, Christian politicians must submit to the government and the law, which is to bring obedience in doing good deeds, not slander, not quarrel and be able to live in obedience. Not going astray, not being a slave to lust, not living in wickedness, not living in malice and hatred and certainly being able to appreciate grace. AbstrakBanyak umat Tuhan yang merasa sungkan atau tidak mau untuk membahas etika politik. Apalagi adanya orang Kristen bila berbicara tentang politik maka secara sepihak akan menjauhi hal tersebut. Karena adanya anggapan bahwa kekristenan tidak boleh dicampuradukan dengan politik. Melalui penelitian ini maka politikus Kristen yang terjun dalam percaturan politik dapat membumikan nilai dan etika politik Kristen dalam teologi Titus 3:1-7 bagi politikus Kristen masa kini sebagai dasar dalam membangun etika teologis politik yang sehat. Menggunakan metode kualitatif deskriptif dengan pendekatan studi literatur maka dapat disimpulkan membumikan nilai dan etika politik Kristen dalam teologi Titus 3:1-7 bagi politikus Kristen masa kini, diperlukan pengertian dan paradigma bahwa politikus Kristen dapat mengetahui hakikat politik dan kepentingannya. Bahkan mereka dapat memahami gereja dan tantangan politik. Supaya politikus yang hidup berintegritas memiliki sikap dan prinsip yang sesuai dengan nilai dan etika politik Kristen. Tentunya politikus Kristen harus tunduk kepada pemerintah dan hukum, yang memang untuk membawa ketaatan dalam melakukan perbuatan baik, tidak memfitnah, tidak bertengkar dan dapat hidup dalam Ketaatan. Tidak Sesat, tidak menjadi budak hawa nafsu, tidak hidup dalam kejahatan, tidak hidup dalam kedengkian dan keji serta kebencian dan tentunya dapat menghargai kasih karunia.
Kurikulum Merdeka dan Merdeka Belajar: Kajian Teologis, Efektivitas dan Tantangan Guru Pendidikan Agama Kristen dan Budi Pekerti
Authors: Mendrofa Arianto 
Published: January 2025

This research was carried out with the aim of analyzing theological studies regarding the challenges of PAK and Budi Pekerti teachers in the effectiveness of implementing the independent learning curriculum. So the method used in this research is a descriptive quantitative approach to effectiveness. The research subjects were Christian students registered at Surakarta City Public Middle Schools, totaling 872 students. The results of data analysis showed that 29.9% stated that moral cultivation would be effective if taught by spiritual mentors in the Church. Meanwhile, 67.4% stated that teachers at school were very effective when instilling morals in their students. In implementing the Merdeka Curriculum, there are challenges for Religious Education and Character Teachers, namely the implementation of general education and the cultivation of character based on the six key dimensions of the Pancasila Student Profile competencies. AbstrakPenelitian ini dilaksanakan dengan tujuan untuk menganalisis survei efektivitas pelaksanaan kurikulum merdeka dan merdeka belajar dalam perspektif kajian teologi terhadap tantangan guru Pendidikan Agama Kristen dan Budi Pekerti. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif deskriptif. Subyek penelitian adalah siswa Kristen yang terdaftar di SMP Negeri se-Kota Surakarta yang berjumlah 872 siswa. Hasil analisa data menunjukkan 29,9% menyatakan bahwa penanaman moral akan efektif jika diajarkan oleh pembina rohani di Gereja. Sedangkan 67,4% menyatakan guru di sekolah sangat efektif apabila menanamkan moral kepada peserta didiknya. Dalam pelaksanaan Kurikulum Merdeka dan Merdeka Belajar terdapat tantangan bagi Guru PAK dan Budi Pekerti yakni terjadinya general education dan penanaman budi pekerti mengacu pada keenam kompetensi dimensi kunci Profil Pelajar Pancasila.