bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory
Authors: Moulder Robert , Välikangas Tommi , Hirvonen M. Karoliina , Suomi Tomi , Brorsson Caroline A. , Lietzén Niina , Bruggraber Sylvaine F. A. , Overbergh Lut , Dunger David B. , Peakman Mark , Chmura Piotr J. , Brunak Soren , Schulte Anke M. , Mathieu Chantal , Knip Mikael , Elo Laura L. , Lahesmaa Riitta ,   on behalf of the INNODIA consortium
Published: August 2023

Abstract
Aims/hypothesis
There is a growing need for markers that could help indicate the decline in beta cell function and recognise the need and efficacy of intervention in type 1 diabetes. Measurements of suitably selected serum markers could potentially provide a non-invasive and easily applicable solution to this challenge. Accordingly, we evaluated a broad panel of proteins previously associated with type 1 diabetes in serum from newly diagnosed individuals during the first year from diagnosis. To uncover associations with beta cell function, comparisons were made between these targeted proteomics measurements and changes in fasting C-peptide levels. To further distinguish proteins linked with the disease status, comparisons were made with measurements of the protein targets in age- and sex-matched autoantibody-negative unaffected family members (UFMs).

Methods
Selected reaction monitoring (SRM) mass spectrometry analyses of serum, targeting 85 type 1 diabetes-associated proteins, were made. Sera from individuals diagnosed under 18 years (n=86) were drawn within 6 weeks of diagnosis and at 3, 6 and 12 months afterwards (288 samples in total). The SRM data were compared with fasting C-peptide/glucose data, which was interpreted as a measure of beta cell function. The protein data were further compared with cross-sectional SRM measurements from UFMs (n=194).

Results
Eleven proteins had statistically significant associations with fasting C-peptide/glucose. Of these, apolipoprotein L1 and glutathione peroxidase 3 (GPX3) displayed the strongest positive and inverse associations, respectively. Changes in GPX3 levels during the first year after diagnosis indicated future fasting C-peptide/glucose levels. In addition, differences in the levels of 13 proteins were observed between the individuals with type 1 diabetes and the matched UFMs. These included GPX3, transthyretin, prothrombin, apolipoprotein C1 and members of the IGF family.

Conclusions/interpretation
The association of several targeted proteins with fasting C-peptide/glucose levels in the first year after diagnosis suggests their connection with the underlying changes accompanying alterations in beta cell function in type 1 diabetes. Moreover, the direction of change in GPX3 during the first year was indicative of subsequent fasting C-peptide/glucose levels, and supports further investigation of this and other serum protein measurements in future studies of beta cell function in type 1 diabetes.

Graphical Abstract
Sarcopenia and Sarcopenic Obesity on Body Composition Analysis is a Significant Predictor of Mortality in Severe Acute Pancreatitis: A Longitudinal Observational Study
Authors: Farquhar Robert , Matthews Scott , Baxter Nesta , Rayers George , Ratnayake Chathura B. B. , Robertson Francis P. , Nandhra Sandip , Lim Wei Boon , Witham Miles , Pandanaboyana Sanjay 
Published: August 2023

AbstractBackgroundThe prevalence and impact of sarcopenia and sarcopenic obesity noted on body composition analysis in severe acute pancreatitis (SAP) is unknown. This study investigates the prevalence of sarcopenia at different timepoints and its effect on post‐pancreatitis complications and mortality.MethodsA prospective database of SAP admissions with organ failure at a single institution from 2015 to 2019 were analysed. Sarcopenia was determined by IMAGE J software on CT. Database was further queried for post‐pancreatitis complications and mortality.Results141 patients with a median age of 59 (range 18–88) and M:F ratio 1.52:1 of were analysed. Sarcopenia was present in 111/141 (79%) patients at admission, 78/79 (99%) at 3 months and 26/36 (72%) at 12 months. 67/111 patients with sarcopenia on admission had sarcopenic obesity. The mortality at 30 days, 3 months and 12 months was 16/141 (11%), 30/141 (21%) and 42/141 (30%) respectively. Mortality was significantly higher in sarcopenic patients at admission (35.14%) compared to the non‐sarcopenic group (10%), P = 0.008). Mortality in the sarcopenic obesity group was significantly higher (45%) compared to the sarcopenic non‐obese group (20%), P = 0.009) at admission. Multivariate logistic regression identified sarcopenic obesity (OR: 2.880), age (OR: 1.048) and number of organ failures (OR: 3.225) as significant predictors of mortality.ConclusionsSarcopenia and Sarcopenic obesity are highly prevalent in SAP patients on admission and during follow up. Furthermore, sarcopenic obesity was shown to be a significant predictor of mortality at admission, suggesting that body composition analysis could be a potential predictive marker of mortality in SAP patients.
Early post-treatment MRI predicts long-term hepatocellular carcinoma response to radiation segmentectomy
Authors: Stocker Daniel , King Michael J. , Homsi Maria El , Gnerre Jeffrey , Marinelli Brett , Wurnig Moritz , Schwartz Myron , Kim Edward , Taouli Bachir 
Published: August 2023

Abstract
Objectives
Radiation segmentectomy using yttrium-90 plays an emerging role in the management of early-stage HCC. However, the value of early post-treatment MRI for response assessment is uncertain. We assessed the value of response criteria obtained early after radiation segmentectomy in predicting long-term response in patients with HCC.

Materials and methods
Patients with HCC who underwent contrast-enhanced MRI before, early, and 12 months after radiation segmentectomy were included in this retrospective single-center study. Three independent radiologists reviewed images at baseline and 1st follow-up after radiation segmentectomy and assessed lesion-based response according to mRECIST, LI-RADS treatment response algorithm (TRA), and image subtraction. The endpoint was response at 12 months based on consensus readout of two separate radiologists. Diagnostic accuracy for predicting complete response (CR) at 12 months based on the 1st post-treatment MRI was calculated.

Results
Eighty patients (M/F 60/20, mean age 67.7 years) with 80 HCCs were assessed (median size baseline, 1.8 cm [IQR, 1.4–2.9 cm]). At 12 months, 74 patients were classified as CR (92.5%), 5 as partial response (6.3%), and 1 as progressive disease (1.2%). Diagnostic accuracy for predicting CR was fair to good for all readers with excellent positive predictive value (PPV): mRECIST (range between 3 readers, accuracy: 0.763–0.825, PPV: 0.966–1), LI-RADS TRA (accuracy: 0.700–0.825, PPV: 0.983–1), and subtraction (accuracy: 0.775–0.825, PPV: 0.967–1), with no difference in accuracy between criteria (p range 0.053 to > 0.9).

Conclusion
mRECIST, LI-RADS TRA, and subtraction obtained on early post-treatment MRI show similar performance for predicting long-term response in patients with HCC treated with radiation segmentectomy.

Clinical relevance statement
Response assessment extracted from early post-treatment MRI after radiation segmentectomy predicts complete response in patients with HCC with high PPV (≥ 0.96).

Key Points
• Early post-treatment response assessment on MRI predicts response in patients with HCC treated with radiation segmentectomy with fair to good accuracy and excellent positive predictive value.
• There was no difference in diagnostic accuracy between mRECIST, LI-RADS, and subtraction for predicting HCC response to radiation segmentectomy.
How can we identify subglottic stenosis in patients with suspected obstructive disease?
Authors: Ntouniadakis Eleftherios , Sundh Josefin , Söderqvist Jeanette , von Beckerath Mathias 
Published: August 2023

Abstract
Purpose
Subglottic stenosis, a rare condition of the upper airway, is frequently misdiagnosed as obstructive lung disease. The aim of this study was to investigate whether subglottic stenosis could be identified and distinguished from asthma and chronic obstructive pulmonary disease (COPD) using spirometry or the dyspnea index (DI).

Methods
The study population included 43 patients with asthma, 31 patients with COPD and 50 patients with subglottic stenosis planned to undergo endoscopic intervention. All patients completed the DI and underwent dynamic spirometry registering both inspiratory and expiratory volumes and flows, including the expiratory disproportion index (EDI), the ratio of forced expiratory volume in 1 s to peak expiratory flow. One-way analysis of variance assessed the discrepancy of the variables among the study groups, and receiver operating curve (ROC) analysis determined the measurement with the best discriminatory power providing a cutoff value, maximizing both sensitivity and specificity.

Results
The only statistically significant variables differing between all three groups were the EDI and the DI. The EDI showed an excellent area under the ROC curve (0.99, p < 0.001) with a cutoff value of 0.39 (98% sensitivity, 96% specificity), followed by DI (0.87, p < 0.001) with a cutoff score of > 25 (83% sensitivity and 78% specificity).

Conclusion
In patients with dyspnea of unknown cause, an increase in EDI should arouse a suspicion of extrathoracic airway obstruction, advocating for further evaluation with laryngotracheoscopy.
The evolution of prey-attraction strategies in spiders: the interplay between foraging and predator avoidance
Authors: Ratz Tom , Bourdiol Julien , Moreau Stéphanie , Vadnais Catherine , Montiglio Pierre-Olivier 
Published: August 2023

AbstractLures and other adaptations for prey attraction are particularly interesting from an evolutionary viewpoint because they are characterized by correlational selection, involve multicomponent signals, and likely reflect a compromise between maximizing conspicuousness to prey while avoiding drawing attention of enemies and predators. Therefore, investigating the evolution of lure and prey-attraction adaptations can help us understand a larger set of traits governing interactions among organisms. We review the literature focusing on spiders (Araneae), which is the most diverse animal group using prey attraction and show that the evolution of prey-attraction strategies must be driven by a trade-off between foraging and predator avoidance. This is because increasing detectability by potential prey often also results in increased detectability by predators higher in the food chain. Thus increasing prey attraction must come at a cost of increased risk of predation. Given this trade-off, we should expect lures and other prey-attraction traits to remain suboptimal despite a potential to reach an optimal level of attractiveness. We argue that the presence of this trade-off and the multivariate nature of prey-attraction traits are two important mechanisms that might maintain the diversity of prey-attraction strategies within and between species. Overall, we aim to stimulate research on this topic and progress in our general understanding of the diversity of predator and prey interactions.
Current and future variability of water supply to a mountain reservoir (Polish Carpathians)
Authors: Bochenek Witold , Wiejaczka Łukasz 
Published: August 2023

AbstractThis study presents the characteristics of the current course of the phenomenon of droughts and floods in the catchment area of a man-made mountainous reservoir and forecasts of water inflow changes to the reservoir over the next three decades. The catchment area of the Klimkówka reservoir on the Ropa River, a tributary of the Wisłoka River, located within the Polish Carpathians was selected for the study. The analysis carried out, using Soil and Water Assessment Tool (SWAT) modelling among other techniques, showed an increase in the importance of low-flow outflow from the upper Ropa catchment and a negative balance of inflow to the reservoir (Q < 2 m3 s−1), manifested by a prolonged duration of low flows and an increase in outflow deficit during the year. The duration of flood flows and the runoff excess during these periods show a constant or decreasing tendency, while the length and excess of runoff increase during large floods. Thus, in the upper Ropa catchment, an increase in the intensity of extreme hydrological phenomena is observed. The prepared forecasts indicate an increase in annual runoff from the catchment in the decades 2021–2030 and 2031–2040 and a marked decrease in the decade 2041–2050. In the annual cycle, the projected changes in the coming decades will take different directions. In December only, throughout the entire period 2021–2050, the outflow will increase, whereas in May it will systematically decrease.
Bloch–Siegert Effect for Surface Nuclear Magnetic Resonance Sounding Experiments in the Unsaturated Zone
Authors: Splith Tobias , Hiller Thomas , Müller-Petke Mike 
Published: August 2023

AbstractThe Bloch–Siegert effect is relevant for NMR experiments where components of the excitation pulse other than the circularly polarized component have an influence on the evolution of the magnetization of the spin system under consideration. For linearly polarized excitation fields this happens at amplitudes higher than roughly one tenth of the magnitude of the static magnetic field. Since surface nuclear magnetic resonance (SNMR) experiments, also called magnetic-resonance-soundings (MRS), are conducted in the relatively low local field of the earth, the Bloch–Siegert effect can quickly become relevant. This is especially the case for SNMR experiments in the unsaturated zone, where due to short relaxation times fast pulses of high intensity must be used. To describe the Bloch–Siegert effect, we use the average Hamiltonian approximation obtained by the Magnus expansion of up to fifth order, as well as the solution of the Bloch equations. The results of these approximations are tested against the Bloch simulations and it is shown that they are only valid for limited ranges of the excitation field amplitude. The influence of the Bloch–Siegert effect on sensitivity kernels is described and verified with experimental data obtained with a small scale SNMR sensor on water containers.
Gender and addiction and other mental disorders comorbidity: sociodemographic, clinical, and treatment differences
Authors: Fernández Silvia Díaz , Miranda Juan José Fernandez , Pastor Francisco Pascual , Muñoz Francisco López 
Published: August 2023

AbstractThe co-occurrence of substance use disorders (SUD) and other mental disorders (OMD) is assumed to be high, but the details are uncertain in Spain. The objective of the present study was to know the prevalence of this comorbidity, as well as the pharmacological treatment, both in specific addiction treatment networks and in mental health networks, with a gender perspective. Observational, multicenter study, with a randomized sample, of patients under treatment for SUD or OMD in Spain (N = 1783). A specific questionnaire, collecting sociodemographic and clinical variables, diagnosed SUD and OMD, and prescribed psychotropic drugs, was completed by treating clinicians. Differences between females and males were searched. A high prevalence of OMD was found in those patients treated for their SUD (71%), and also of diagnoses of SUD (59%) in people treated for OMD. Significant relationships between addiction to certain substances and specific mental disorders were found (with no main differences between women and men). The treatments for OMD were very common in the addiction treatment networks, but that of SUDs in those patients treated in the mental health networks was less than expected. A high prescription of benzodiazepines was found. Women were less frequently diagnosed with cannabis, opioid, and especially cocaine use disorders, and they had fewer psychotic disorders and more affective, anxiety, sleep, and eating disorders, with the rest being the same, including personality disorders. Women had fewer treatments with agonists and more with antagonists, and more prescriptions of anxiolytics and antidepressants. This study provides preliminary information on the coexistence in routine clinical practice of addictive disorders and other mental disorders in Spain, and on the treatment provided, and shows differences in prevalence and clinical characteristics, and especially in treatment approaches between women and men. Thus, should be useful to adapt the treatment response with greater precision, and with a gender perspective.
Urban environment determines population genetics in the green toad, Bufotes viridis
Authors: Vargová Viktória , Gužiová Damiána , Balogová Monika , Pipová Natália , Uhrin Marcel , Kaňuch Peter 
Published: August 2023

AbstractHeavily urbanized areas can hinder dispersal and gene flow between amphibian populations. Given the growth potential of urbanization, it is important to examine how this specific environment shapes their genetic patterns at the local scale. The ability of the European green toad to successfully colonize large human settlements has been convincingly confirmed in the recent past, but little is known about its population genetics under these new conditions. In this study, we examined the effects of the environment on genetic variation, population structure, and the level of gene flow in populations of this amphibian in the city of Košice and the adjacent rural area (eastern Slovakia) using a set of neutral genetic markers. We found that urban populations had lower genetic variability than populations in adjacent rural areas; however, the degree of inbreeding was relatively low in all samples. Genetic differentiation was higher, and gene flow was more restricted in urban area, although geographic distances between sites were significantly less than in rural area (2–4 km versus 6–13 km). Our analyses suggested genetic isolation of urban populations at sites with less suitable habitat for green toads. In contrast, admixture of the population inhabiting the large city park, established on a former floodplain, with all rural populations was likely the result of an intense historical gene flow. The densely developed environment of the other urban sites likely presents a strong barrier to gene flow. The lack of suitable wetland habitat prior to development suggests that these sites were only recently colonized by a limited number of founders. Thus, we found differential effects of the city on the population structure of the green toad. Understanding current local genetic variation and structure is important for future conservation plans in urban environments.
How Common is Cheating in Online Exams and did it Increase During the COVID-19 Pandemic? A Systematic Review
Authors: Newton Philip M. , Essex Keioni 
Published: August 2023

AbstractAcademic misconduct is a threat to the validity and reliability of online examinations, and media reports suggest that misconduct spiked dramatically in higher education during the emergency shift to online exams caused by the COVID-19 pandemic. This study reviewed survey research to determine how common it is for university students to admit cheating in online exams, and how and why they do it. We also assessed whether these self-reports of cheating increased during the COVID-19 pandemic, along with an evaluation of the quality of the research evidence which addressed these questions. 25 samples were identified from 19 Studies, including 4672 participants, going back to 2012. Online exam cheating was self-reported by a substantial minority (44.7%) of students in total. Pre-COVID this was 29.9%, but during COVID cheating jumped to 54.7%, although these samples were more heterogenous. Individual cheating was more common than group cheating, and the most common reason students reported for cheating was simply that there was an opportunity to do so. Remote proctoring appeared to reduce the occurrence of cheating, although data were limited. However there were a number of methodological features which reduce confidence in the accuracy of all these findings. Most samples were collected using designs which makes it likely that online exam cheating is under-reported, for example using convenience sampling, a modest sample size and insufficient information to calculate response rate. No studies considered whether samples were representative of their population. Future approaches to online exams should consider how the basic validity of examinations can be maintained, considering the substantial numbers of students who appear to be willing to admit engaging in misconduct. Future research on academic misconduct would benefit from using large representative samples, guaranteeing participants anonymity.
Multifactorial Diffusion of Chloride Ions in Concrete considering the Non-linear Voltage Distortion of Other Species
Authors: Zacchei Enrico , Lizarazo-Marriaga Juan , García-Sánchez Felipe , Tadeu Antonio 
Published: August 2023

AbstractOne of the most relevant deterioration mechanisms of reinforced concrete (RC) structures is the corrosion of steel bars by chloride ions. The service life of structures could be extended by monitoring this process. The lack of correlation data between chloride ion diffusion and the electrical field has meant that alternative methods have been developed in this paper. One such method considers diffusivity and the electrical field as non-constant, although they are usually assumed constant, that is, without there being any variability of the involved factors. Therefore, a multi-factorial diffusivity that accounts for the material characteristics and environmental variations is adopted. In addition, an innovative stochastic approach to evaluate the variation of the electrical field while accounting for the non-linear voltage distortion, which considers a multispecies model, has been proposed. More complete 1D/2D electro-mechanical models that are solved by advanced numerical and analytical solutions for electro-mechanical diffusion have been developed. Results show that spatiotemporal numerical models estimate the chloride concentration well, estimating more reliable scenarios to provide information on the safety situation of the structure and make it more sustainable by employing successful preventive treatments.
Low-temperature synthesis of doped MnO2–carbon dots nanocomposite: an analysis of nanostructure and electrical properties
Authors: Hastuti E. , Fitriana F. , Zainuri M. , Suasmoro S. 
Published: August 2023

AbstractThe synthesis of δ-MnO2, δ-MnO2 carbon dots nanocomposite, and Fe/Cu-doped δ-MnO2 carbon dots nanocomposite has been successfully carried out through a stirring process at room temperature and 80 °C. The synthesized powder shows a low crystallization determined through XRD and TEM analysis. Furthermore, the carbon dots are well attached to MnO2 performing a core–shell composite material, while the doping ions Fe and Cu were incorporated into the matrix substitute Mn in the MnO6 octahedron, although potassium ions were also detected. The manganese possess an oxidation state of + 3 and + 4, which promotes the oxygen vacancy creation $${V}_{\mathrm{O}}^{\cdot\cdot}$$

V

O

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denoting the conductivity decrease.