bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Tingkat Stres Mahasiswa Dalam Mengikuti Pembelajaran Daring Pada Mahasiswa Prodi Ners Tingkat III Di STIKes Santa Elisabeth Medan Tahun 2021
Authors: Br Karo Mestiana , Br Barus Mardiati , Br Sitinjak Sumiati Petronella , Sri H Ginting Friska 
Published: July 2023

Pembelajaran daring merupakan pembelajaran yang menggunakan jaringan internet dengan aksesibilitas, konektivitas, fleksibilitas, dan kemampuan untuk memunculkan berbagai jenis interaksi pembelajaran. Pelaksanaan pembelajaran daring tidak terlepas dari beberapa masalah dan hambatan yang mengakibatkan mahasiswa megalami stres. Stres merupakan salah satu reaksi atau respon psikologis manusia saat dihadapkan pada hal-hal yang dirasa telah melampaui batas atau dianggap sulit untuk dihadapi. Tujuan penelitian ini untuk mengetahui gambaran tingkat stres mahasiswa dalam mengikuti pembelajaran daring pada mahasiswa prodi Ners tingkat III di STIKes Santa Elisabeth Medan. Penelitian ini menggunakan metode penelitian deskriptif. Teknik pengambilan sampel menggunakan Total Sampling dengan jumlah sampel 94 responden. Alat ukur yang digunakan berupa kuesioner yang dibagikan secara online melalui google form. Berdasarkan hasil penelitian bahwa dari 94 responden paling banyak mengalami tingkat stres sedang sebanyak 24 responden (25,5%) dan paling sedikit mengalami tingkat stres sangat berat sebanyak 10 responden (10,6%). Proses penerapan pembelajaran daring memiliki dampak terhadap tingkat stres mahasiswa. Diharapkan menjadi bahan evaluasi agar pembelajaran daring dapat dilaksanakan dengan baik oleh mahasiswa, dosen dan pihak instansi pendidikan.
Kebermaknaan Hidup Masyarakat Urban dalam Perspektif Hanna Djumhana Bastaman: Kajian Dimensi Spiritual Logoterapi
Authors: Maknunah Lulu , Fauzi Ahmad 
Published: July 2023

Zaman yang semakin berkembang dan modern menjadikan nilai-nilai dimensi spiritual sangat di butuhkan dikarenakan saat ini banyak masyarakat terutama masyaraakt urban kehilangan pondasi dalam dirinya. Mereka lebih mementikan hal yang bersifat eksternal padahal internal dalam dirinya sangat kosong dan kehilangan kebermaknaan hidup. Dalam hal ini Hanna Djumhanna Bastaman menjawab akan segala keresahan hidup masyarakat urban untuk menemukan kebermaknaan hidupnya melalui teorinya yaitu panca cara temuan makna yang kemudian secara bertahap mereka akan menemukan kebermaknaan hidupnya dan dapat survive di zaman saat ini.
Knowledge flows and languages of publication
Authors: Kuteeva Maria 
Published: July 2023

Abstract
Ongoing debates in the humanities and social sciences concern different ways in which knowledge is viewed and
constructed. As the main language of academic publication, English features prominently in these debates. In this
Perspectives piece, I discuss how knowledge flows and language uses are intertwined, and how English serves
both as a bridge and a fence in the context of international knowledge exchanges. In particular, the tensions around English and
multilingualism, as well as variability within English, are discussed in connection with language policies, editorial practices,
and structural inequalities. I conclude by considering the role of institutional structures vis-à-vis individual authors, peer
reviewers, and editors, and offer a few suggestions on how to address the limitations of centripetal English-medium
publishing.
Long locking plate combined with locking attachment plate in patients with periprosthetic femoral fracture around ipsilateral stem after total knee arthroplasty
Authors: Shon Oog-Jin , Cho Seung Jae , Kim Gi Beom 
Published: July 2023

Abstract
Background
The purpose of this study was to introduce the surgical technique using long locking plate and locking attachment plate (LAP) in patient with periprosthetic femoral fracture around ipsilateral stem after total knee arthroplasty (TKA). Moreover, we sought to investigate the outcomes of this fixation technique and to propose a new subtype in the existing classification of periprosthetic femoral fractures.

Methods
From January 2013 to January 2022, thirty-four consecutive periprosthetic femoral fractures around ipsilateral stem following TKA with minimum 1-year follow-up were enrolled in this study. Most cases were fixed with long-locking plate and LAP using the MIPO technique. For subgroup analysis, we classified patients with stemmed hip implant (group H) and stemmed knee implant (group K). Bone union, American Knee Society Score (AKSS) scale, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, the Western Ontario and McMaster Universities Osteoarthritis Index for pain and function, and range of motion were investigated.

Results
The number of group H and K were 24 patients (70.6%) and 10 patients (29.4%), respectively. The mean age at operation was 71.5 years (range, 65‒85 years), and the mean follow-up period was 27.5 months (range, 12‒72 months). Bone union was confirmed radiographically in all patients, and the mean union time was 4.9 months (range, 3.5‒6 months). There were no significant differences in radiographic and clinical outcomes between the groups.

Conclusions
Long-locking plate combined with LAP showed favorable radiographic and clinical outcomes in patients with periprosthetic femoral fracture around ipsilateral stem after TKA.

Level of evidence
Level IV, Retrospective Case Series.
Three Steps Novel Machine Learning Method Classifies Uncertain MEFV Gene Variants
Authors: Alay Mustafa Tarik , Demir İbrahim , Kirişçi Murat 
Published: July 2023

Abstract
Introduction:
The International Study Group for Systemic Autoinflammatory Diseases (INSAID) consensus criteria revealed that the clinical outcomes of more than half of the MEFV gene variants are uncertain. In this study, we estabilished a novel approach for more accurate classification of MEFV gene variants by using the optimal number of amino acid prediction scores and machine-learning algorithms. Our goal was to determine a more accurate classification of MEFV variants while also reducing the uncertainties.
Material-Methods:
We extracted variants of the MEFV gene from the infevers database ,and point mutations were included, others excluded from the study. We then determined the optimal number of in silico instruments for our model. On the training dataset, we implemented seven machine learning algorithms on MEFV gene variants with known clinical effects. We evaluated the effectiveness of our model in three steps: First, we performed machine-learning algorithms on the training dataset and implemented those with a prediction accuracy of greater than 90 percent. Second, we compared our prediction results to existing algorithms and studies. Third, we evaluated our outcomes functional and clinical level.
Results
We included 266 of 381 MEFV gene variants and four computational tools in a study. Our algorithm classified Likely pathogenic (LP) variants with an accuracy of 96.6% while classifying 97.6% of Likely Benign (LB) variants. Among the machine learning methods used to classify MEFV variants, our classification method yielded the most accurate results on training datasets. Most of the predictors classified LB variants with higher accuracy than 90% however, LP classification showed a wide range of variety in accuracy scores between 2% − 62.5%. Disease-causing MEFV variants are frequently located in domains. Functional and clinical level evaluation compatible with our classification results.
Discussion
The comparison indicated that LP variant prediction is the biggest problem in variant classification, and our method might be a candidate for solving this problem with the 96.67% accuracy. Considering that 60% of the clinical effects of MEFV gene variants are unresolved, evaluating our methods in conjunction with the clinical manifestations of patients significantly simplifies the interpretation of unknown variants
Wiedza pielęgniarek na temat profilaktyki rozprzestrzeniania zakażenia bakterią Clostridium difficile
Authors: Grączewska Natalia 
Published: July 2023

Wstęp. Zakażenia szpitalne dotyczą wszystkich placówek ochrony zdrowia na całym świecie. Pomimo rozwoju medycyny, stanowią duże zagrożenie nie tylko dla pacjentów hospitalizowanych, lecz także dla pracowników ochrony zdrowia oraz osób odwiedzających placówkę. Zakażenia związane z opieką zdrowotną wpływają na pogorszenie przebiegu choroby podstawowej, wydłużają czas pobytu pacjenta, zwiększają koszty leczenia oraz wpływają na wzrost śmiertelności pacjentów. Szerokie rozprzestrzenienie się zakażenia może doprowadzić do zamknięcia oddziału czy szpitala.
Cel. Celem pracy jest ocena poziomu wiedzy pielęgniarek na temat rozprzestrzeniania zakażenia bakterią Clostridium difficile.
Materiał i metody. Przedmiotem badań jest wiedza pielęgniarek na temat rozprzestrzeniania zakażenia bakterią Clostridium difficile. Dla potrzeb pracy skorzystano z metody sondażu diagnostycznego a narzędziem badawczym był autorski kwestionariusz ankiety.
Wyniki. Poziom wiedzy najwyższy był w grupie osób w wieku 41 –50 lat, najniższy w grupie osób w wieku do 30 lat. Wykazano zależność między stanem posiadanej wiedzy na temat rozprzestrzeniania się zakażenia bakterią Clostridium difficile a stażem pracy. Zaobserwowano, że poziom wiedzy najwyższy był w grupie osób pracujących ponad 20 lat, najniższy w grupie osób pracujących do 5 lat. Wykazano zależność między stanem posiadanej wiedzy na temat rozprzestrzeniania się zakażenia bakterią Clostridium difficile a oceną własnego deficytu wiedzy. Zaobserwowano, że poziom wiedzy najwyższy był w grupie osób oceniających deficyt swojej wiedzy w zakresie samego zakażenia bakterią Clostridium difficile, najniższy w grupie osób oceniających deficyt swojej wiedzy w zakresie higieny.
Wnioski. Analiza wyników przeprowadzonych badań potwierdziła, że staż pracy oraz tytuł zawodowy pozytywnie kształtuje znajomość procedur wśród personelu. Ankietowane pielęgniarki są dobrze przygotowane do pracy z pacjentem zarażonym CD.
Perbedaan Karakteristik Kemampuan Koordinasi Gerak Berdasarkan Usia dan Jenis Kelamin Siswa di Sekolah Dasar Negeri Kecamatan Air Hangat Barat
Authors: Putra Govinda Noza , Bakhtiar Syahrial , Masrun Masrun , Komaini Anton 
Published: July 2023

Masalah dalam penelitian ini adalah masih rendahnya kemampuan koordinasi gerak berdasarkan usia dan jenis kelamin Siswa. Penelitian ini bertujuan untuk mengetahui Perbedaan Karakteristik Kemampuan Koordinasi Gerak Berdasarkan Usia dan Jenis Kelamin Siswa di Sekolah Dasar Negeri Kecamatan Air Hangat Barat. Penelitian ini dilakukan dengan menggunakan rancangan faktorial 2 x 2. Usia dan jenis kelamin adalah sebagai variabel faktor, sedangkan karakteristik kemampuan koordinasi gerak merupakan variabel terikat. Sampel dalam penelitian ini adalah siswa di Sekolah Dasar Negeri Kecamatan Air Hangat Barat yang berjumlah 180 orang siswa dari tingkatan umur 7 sampai 9 tahun dan 10 samapai 12 tahun dengan jenis kelamin laki-laki dan perempuan. Metode pengabilan sampel yang digunakan dalam penelitian ini adalah teknik probability sampling. Pengumpulan data koordinasi gerak yaitu: (1) balance beam (2) Eye-hand coordination, (3) jumping sideway, (4) moving sideways, dan (5) Shuttle Throw. Data koordinasi gerak yang diperoleh selanjutnya dianalisis dengan statistik inferensial ANOVA 2 x 2 dua jalur (two way ANOVA ). Berdasarkan hasil analisis data dan interpretasi dari hasil penelitian menunjukan bahwa: (1) Terdapat perbedaan karakteristik kemampuan koordinasi gerak siswa usia 7 - 9 tahun dengan siswa usia 10 - 12 tahun. (2) Terdapat perbedaan karakteristik kemampuan koordinasi gerak siswa antara jenis kelamin laki-laki dengan jenis kelamin perempuan. (3) Terdapat perbedaan interaksi antara usia dan jenis kelamin terhadap karakteristik kemampuan koordinasi gerak, (4) Karakteristik kemampuan koordinasi gerak siswa usia 7 - 9 tahun memiliki perbedaan dengan usia 10 - 12 tahun pada pada jenis kelamin laki-laki, (5) Karakteristik kemampuan koordinasi gerak siswa usia 7 - 9 tahun memiliki perbedaan dengan usia 10 - 12 tahun pada pada jenis kelamin perempuan.
Conflicts in Modern Society
Authors: P.M Suresh Kumar 
Published: July 2023

Conflicts are inherent in any society. They are products of social life and unavoidable. Where people live collectively conflicts arise both inter-personal and inter-group, although people are mutually dependent and live together for the common good. Conflict could be traced to the time of ancient feudal society down to agricultural and further to industrial society. However, the factors contributing to it differ and the way it is manifested also varies. Conflicts arise from structural inequalities and resulting differential distribution of power and resources. Inequalities give way to competition and competition results in conflict. In ancient feudal societies huge concentration of land in the hands of a few led to subservience by the serfs and vassals before the landlords. In agrarian societies, the utilization of land and evolving relations determined social life. Combined with the complex nature of the caste system it became an oppressive instrument to establish the supremacy of the land-owning class. This battle kept the groups in constant confrontation. In industrial societies capital and mode of production divided society into two opposing classes always conflicting with each other. Slowly a pattern of urban social life evolved that command time, speed, and quality of life. These became a key concern, ushering in a new social order of the modern era. Nevertheless, the undercurrents of conflict that pervaded throughout continued to induce change as well as restore stability. Conflicts in modern society are displayed at work and workplace as well as between hierarchies of professions and political processes. Institutions keep constantly struggling for securing power, gaining interest, or establish ideology. The present study aims to analyze the dimensions of conflict in modern society and its implications. Three forms of conflict namely power conflict, interest conflict, and conflict of ideologies are discussed as they apply to various groups or institutions.
PENERAPAN FUN REWARDS UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS II SEKOLAH DASAR
Authors: Efendi Nofriza , Indriyani Desi , Fauziah Muhardila , Friska Sonia Yulia 
Published: July 2023

ABSTRAKPenguatan dan penanaman motivasi belajar ada di tangan guru, karena unsur terpenting dalam kegiatan pembelajaran adalah guru. Penelitian ini bertujuan untuk meningkatkan motivasi belajar siswa melalui metode Fun Reward. Jenis penelitian yang digunakan adalah Penelitian Tindakan Kelas. Sedangkan subjek penelitian ini adalah siswa kelas II SDN 13 Lolong Kota Padang, dengan jumlah siswa 20 orang yang terdiri dari 10 siswa laki-laki dan 10 siswa perempuan. Hasil penelitian menunjukkan adanya peningkatan motivasi belajar anak melalui penerapan metode Fun Reward dengan kualifikasi sangat baik dan dinyatakan berhasil dengan skor pencapaian kelas 95% pada siklus II, meningkat dari 72% pada siklus I dan 69% pada siklus I. prasiklus, dan 35% pada prasiklus. Berdasarkan data tersebut dapat disimpulkan bahwa penerapan Fun Rewards dapat meningkatkan motivasi belajar siswa karena pelajaran yang disajikan guru menyenangkan.Kata Kunci: Penerapan, fun rewards, motivasi, siswa ABSTRACTStrengthening and instilling learning motivation is in the hands of the teacher, because the most important element in learning activities is the teacher. This study aims to increase student motivation through the Fun Reward method. The type of research used is Classroom Action Research. Meanwhile, the subjects of this study were class II students at SDN 13 Lolong Kota Padang, with a total of 20 students consisting of 10 male students and 10 female students. The results showed that there was an increase in children's learning motivation through the application of the Fun Reward method with very good qualifications and was declared successful with a grade achievement score of 95% in cycle II, an increase from 72% in cycle I and 69% in cycle I pre-cycle, and 35% in cycle I. pracycle. Based on these data it can be concluded that the application of Fun Rewards can increase student motivation because the lessons presented by the teacher are fun.Keywords: Application, fun rewards, motivation, students
Association of Reducing the Recommended Colorectal Cancer Screening Age With Cancer Incidence, Mortality, and Costs in Canada Using OncoSim
Authors: Kalyta Anastasia , Ruan Yibing , Telford Jennifer J. , De Vera Mary A. , Peacock Stuart , Brown Carl , Donnellan Fergal , Gill Sharlene , Brenner Darren R. , Loree Jonathan M. 
Published: July 2023

ImportanceRecent US guideline updates have advocated for colorectal cancer (CRC) screening to begin at age 45 years in average-risk adults, whereas Canadian screening programs continue to begin screening at age 50 years. Similarities in early-onset CRC rates in Canada and the US warrant discussion of earlier screening in Canada, but there is a lack of Canadian-specific modeling data to inform this.ObjectiveTo estimate the association of a lowered initiation age for CRC screening by biennial fecal immunochemical test (FIT) with CRC incidence, mortality, and health care system costs in Canada.Design, Setting, and Participants/ExposuresThis economic evaluation computational study used microsimulation modeling via the OncoSim platform.Main Outcomes and MeasuresModeled rates of CRC incidence, mortality, and health care costs in Canadian dollars.ResultsThis analysis included 4 birth cohorts (1973-1977, 1978-1982, 1983-1987, and 1988-1992) representative of the Canadian population accounting for previously documented effects of increasing CRC incidence in younger birth cohorts. Screening initiation at age 45 years resulted in a net 12 188 fewer CRC cases, 5261 fewer CRC deaths, and an added 92 112 quality-adjusted life-years (QALYs) to the cohort population over a 40-year period relative to screening from age 50 years. Screening initiation at age 40 years yielded 18 135 fewer CRC cases, 7988 fewer CRC deaths, and 150 373 QALYs. The cost per QALY decreased with younger birth cohorts to a cost of $762 per QALY when Canadians born in 1988 to 1992 began screening at age 45 years or $2622 per QALY with screening initiation at age 40 years. Although costs associated with screening and resulting therapeutic interventions increased with earlier screening, the overall health care system cost of managing CRC decreased.Conclusions and RelevanceThis economic evaluation study using microsimulation modeling found that earlier screening may reduce CRC disease burden and add life-years to the Canadian population at a modest cost. Guideline changes suggesting earlier CRC screening in Canada may be justified, but evaluation of the resulting effects on colonoscopy capacity is necessary.
Monitor unit verification for Varian TrueBeam VMAT plans using Monte Carlo calculations and phase space data
Authors: Pant Ankit , Miri Narges , Bhagroo Stephen , Mathews Joshua A. , Nazareth Daryl P. 
Published: July 2023

AbstractTo use the open‐source Monte Carlo (MC) software calculations for TPS monitor unit verification of VMAT plans, delivered with the Varian TrueBeam linear accelerator, and compare the results with a commercial software product, following the guidelines set in AAPM Task Group 219. The TrueBeam is modeled in EGSnrc using the Varian‐provided phase‐space files. Thirteen VMAT TrueBeam treatment plans representing various anatomical regions were evaluated, comprising 37 treatment arcs. VMAT plans simulations were performed on a computing cluster, using 107–109 particle histories per arc. Point dose differences at five reference points per arc were compared between Eclipse, MC, and the commercial software, MUCheck. MC simulation with 5 × 107 histories per arc offered good agreement with Eclipse and a reasonable average calculation time of 9–18 min per full plan. The average absolute difference was 3.0%, with only 22% of all points exceeding the 5% action limit. In contrast, the MUCheck average absolute difference was 8.4%, with 60% of points exceeding the 5% dose difference. Lung plans were particularly problematic for MUCheck, with an average absolute difference of approximately 16%. Our EGSnrc‐based MC framework can be used for the MU verification of VMAT plans calculated for the Varian TrueBeam; furthermore, our phase space approach can be adapted to other treatment devices by using appropriate phase space files. The use of 5 × 107 histories consistently satisfied the 5% action limit across all plan types for the majority of points, performing significantly better than a commercial MU verification system, MUCheck. As faster processors and cloud computing facilities become even more widely available, this approach can be readily implemented in clinical settings.
A Coenzyme‐Based Deep Eutectic Supramolecular Polymer Bioadhesive
Authors: Cui Chunyan , Sun Yage , Nie Xiongfeng , Yang Xuxuan , Wang Fushuo , Liu Wenguang 
Published: July 2023

Abstractα‐lipoic acid (LA), a coenzyme, has proved to have excellent antioxidant and antibacterial activities; however, its intrinsic hydrophobicity and metastability of polyLA remains a major challenge for the application of LA‐based bulk materials in biomedical field. Herein, a self‐stabilized LA‐based deep eutectic supramolecular polymer (LA‐DESP) adhesive is created by one‐step heating the mixture of LA and sodium α‐lipoate (LA‐Na) (S‐, R‐isomer, racemate) without introducing any exogenous stabilizing molecules. The underlying deep eutectic effect in LA/LA‐Na is unveiled to be originated from the multiple hydrogen bonds between polyLA and polyLA‐Na, which not only prevent polyLA depolymerization but also lower the melting point of LA‐DESP to the near body and pathological temperature. Copolymerization of LA and LA‐Na slows down the dissociation of polyLA‐Na, thus affording sustainable release of bioactive LA‐based small molecules and satisfactory antioxidant and antibacterial functions. Also, the LA‐DESP exhibits fast and tough adhesion to diverse substrates, including wet tissues, relying on its in situ curing property and rich carboxyl groups. The LA‐DESP is explored as a tissue sealant, which can well replace surgical suture to enhance the wound healing of skin incision in a rat model. The unprecedented deep eutectic effect will provide a new strategy for the development of LA‐based bioadhesives.
Unlocking the Potential of Field Effect Transistor (FET) Biosensors: A Perspective on Methodological Advances in Computational and Molecular Biology
Authors: Rexha Jesmina , Perta Nunzio , Roscioni Agnese , Motta Stefano , La Teana Anna , Maragliano Luca , Romagnoli Alice , Di Marino Daniele 
Published: July 2023

AbstractField‐effect transistor (FET)‐based sensors are increasingly gaining relevance in diagnostic, healthcare, and environmental monitoring applications. A FET operates by transducing chemical interactions between a surface‐immobilized bioreceptor and the target analyte into a detectable electrical signal. FET biosensors can detect and monitor molecules (i.e., biomarkers, small molecules, viruses, bacterias) present in liquid samples, making a “liquid gate” configuration of FETs the most suitable approach. However, this FET architecture presents dimensional constraints that affect bioreceptors’ stability and immobilization in the liquid phase. To overcome these limitations, herein, a combination of computational and molecular biology techniques for improving bioreceptors' applicability in biosensing is proposed. This results in the optimized and problem‐tailored protein receptors for specific FET biosensors applications, thus enhancing their overall performance. The interplay between the computational and experimental approaches will represent a ground‐breaking solution for the development of next‐generation biosensors.