bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent Warthin tumor and Kimura disease: a case report
Authors: Almazyad Asma , Al Khudiri Naheel , Alshieban Saeed S. , Pharaon Majed M. 
Published: January 2023

AbstractBackgroundWarthin tumor (WT) is a common benign salivary tumor of the parotid gland. Clinically, it occurs in men in their fifth to seventh decades who typically smoke cigarettes. WTs have been reported with different head and neck neoplasms and other salivary gland tumors within the same or another salivary gland. Kimura disease (KD) is a rare chronic inflammatory disease with unknown etiology affecting young to middle-aged Asian men. KD presents as an asymptomatic nodule in the head and neck area, with regional lymphadenopathy and salivary gland involvement.Case presentationA 64-year-old Arabic man presented with a 10-year history of an asymptomatic swelling of the left face. Computed tomography showed a well-defined, multicystic mass with heterogeneous enhancement. The resected mass was composed of two distinct components. There was a well-demarcated proliferation of papillary and cystic oncocytic epithelium with lymphoid stroma, consistent with WT. Some areas exhibited sclerotic fibrosis, with multiple lymphoid follicles showing folliculolysis, follicular hyperplasia, and eosinophilic infiltrate. The patient’s immunoglobulin E level serum was elevated, confirming a coexisting KD. The patient underwent a left superficial parotidectomy, with no recurrence at a 30-month follow-up.ConclusionThis report describes the first concurrent case of WT and KD in the parotid gland.
Self-critical perfectionism mediates the relationship between self-esteem and satisfaction with life in Lebanese university students
Authors: Fekih-Romdhane Feten , Sawma Toni , Obeid Sahar , Hallit Souheil 
Published: January 2023

Abstract
Background
The psychological mechanisms that underlie the relationship between self-esteem and life satisfaction remain unclear and not well-understood. We sought through the present study to test the hypothesis that perfectionism plays a significant mediating role in the association between self-esteem and satisfaction with life among Lebanese university students.

Methods
A cross-sectional study was performed in a sample of 363 students (61.7% females, mean age = 22.65 ± 3.48 years). Three research instruments were used: satisfaction with life scale, Rosenberg self-esteem scale and big three perfectionism scale.

Results
Higher self-esteem was significantly associated with lower self-critical perfectionism (Beta = − 0.47), whereas higher self-critical perfectionism was significantly associated with lower satisfaction in life (Beta = − 0.29). Finally, higher self-esteem was significantly and directly associated with higher satisfaction with life (Beta = 0.48).

Conclusion
The present preliminary findings point to the role of self-critical perfectionism as a buffer between self-esteem and satisfaction with life, suggesting the roles of self-esteem and perfectionism as promising avenues for promoting satisfaction with life in adolescent students.
The Effectiveness of Exercise Physiology Services During the COVID-19 Pandemic: A Pragmatic Cohort Study
Authors: Owen Patrick J. , Keating Shelley E. , Askew Christopher D. , Clanchy Kelly M. , Jansons Paul , Maddison Ralph , Maiorana Andrew , McVicar Jenna , Robinson Suzanne , Neason Christopher , Clarkson Matthew J. , Mundell Niamh L. 
Published: January 2023

Abstract
Background
The COVID-19 pandemic markedly changed how healthcare services are delivered and telehealth delivery has increased worldwide. Whether changes in healthcare delivery borne from the COVID-19 pandemic impact effectiveness is unknown. Therefore, we examined the effectiveness of exercise physiology services provided during the COVID-19 pandemic.

Methods
This prospective cohort study included 138 clients who received exercise physiology services during the initial COVID-19 pandemic. Outcome measures of interest were EQ-5D-5L, EQ-VAS, patient-specific functional scale, numeric pain rating scale and goal attainment scaling.

Results
Most (59%, n = 82) clients received in-person delivery only, whereas 8% (n = 11) received telehealth delivery only and 33% (n = 45) received a combination of delivery modes. Mean (SD) treatment duration was 11 (7) weeks and included 12 (6) sessions lasting 48 (9) minutes. The majority (73%, n = 101) of clients completed > 80% of exercise sessions. Exercise physiology improved mobility by 14% (β = 0.23, P = 0.003), capacity to complete usual activities by 18% (β = 0.29, P < 0.001), capacity to complete important activities that the client was unable to do or having difficulty performing by 54% (β = 2.46, P < 0.001), current pain intensity by 16% (β = − 0.55, P = 0.038) and goal attainment scaling t-scores by 50% (β = 18.37, P < 0.001). Effectiveness did not differ between delivery modes (all: P > 0.087).

Conclusions
Exercise physiology services provided during the COVID-19 pandemic improved a range of client-reported outcomes regardless of delivery mode. Further exploration of cost-effectiveness is warranted.
Recreational Athletes’ Use of Performance-Enhancing Substances: Results from the First European Randomized Response Technique Survey
Authors: Christiansen Ask Vest , Frenger Monika , Chirico Andrea , Pitsch Werner 
Published: January 2023

Abstract
Background and Aim
Measuring the prevalence of doping in recreational sport is difficult. However, to fit their initiatives, National Anti-Doping Organizations are interested in knowing the numbers, so their scarce resources are not wasted. The present study aimed to estimate the prevalence of doping and over-the-counter medicine use for performance enhancement among recreational athletes in eight European countries.

Design
A survey covering + 200 sports aimed at recreational athletes 15 years and older was distributed via social media to sports clubs and individuals in eight European countries. To overcome social desirability bias, we applied indirect questioning by using the Randomized Response Technique and asked for the use of over-the-counter medicine and doping for the year 2019.

Results
The prevalence of the use of over-the-counter medications for performance enhancement was estimated at 10.4%. We differentiated between the concept of “doping” as the behavior to enhance performance in a certain sport and the concept of “a doper” as a property of a person. The prevalence of dopers in recreational sport was found to be 0.4%, with 3.1% male and 0% female dopers. Responses were separated into four categories: “Artistic sports,” “Combat sports,” “Games,” and “CGS sports” (i.e., sports measured in centimeters, grams, and seconds). The overall prevalence of doping in recreational sports was found to be 1.6%, and the results from Artistic and CGS sports did not differ significantly from this. However, in Games we found an estimated doping prevalence of 6.9%.

Discussion
The estimates for the prevalence of dopers and doping in this study do not equal Anti-Doping Rule Violations as stipulated by the World Anti-Doping Agency. Still, while doping is not absent in recreational sport in Europe, it appears to be a low frequent phenomenon. Also, the differences in doping prevalence between the sports categories might reflect structural and competition-related differences, rather than differences in the logic of the sporting competition or discipline-related subcultures.

Conclusion
While few recreational athletes appear to use illegal drugs to enhance performance, those who do use them are more often men than women. Yet, 1 in 10 recreational athletes uses over-the-counter medication for performance enhancement and more than 4 out of 10 use medication for other reasons than performance enhancement when doing sports. The highest doping prevalence was found in the sub-category of Games, which can likely be attributed to competition-related differences between the categories. Therefore, research on doping in recreational sports needs tailored approaches to come to a better understanding of the phenomenon.
The influence of CEO’s financial literacy on SMEs technological innovation: the mediating effects of MCS and risk-taking
Authors: Duréndez Antonio , Dieguez-Soto Julio , Madrid-Guijarro Antonia 
Published: January 2023

AbstractPrevious literature showed mixed results about the impact of CEOs’ financial literacy (CFL) on small and medium-sized enterprises’ (SMEs) innovation. This relationship can be motivated by relevant variables, which are missing in the previous literature and make a difference as mediators. In this sense, based on the theoretical framework related to upper echelon theory and resource-based view, this study focuses on the mediating effect of risk-taking attitude and management control systems (MCS) variables. Empirical data from 310 SMEs gathered using a qualitative research questionnaire are analyzed using structural equation modeling methodology. Specifically, estimations are carried out considering the partial least square method. Findings show that MCS and managers’ risk attitudes fully mediate the relationship between financial literacy (FL) and innovation. Between these two mediating variables, the implementation of MCS stands out because it also enables the mediating effect of CEOs’ risk-taking in the CFL–technological innovation relationship. As the results do not support the significant direct relationship between FL and risk attitude, they confirm an indirect effect through MCS. Furthermore, based on the study findings, SMEs’ directors and owners, business associations, and public authorities can improve SMEs’ technological innovation by implementing training programs and policies to foster CFL. They can also acknowledge the interdependency between organizational factors and individual characteristics to enhance SMEs’ technological innovation.
Using global feedback to induce learning of gist of abnormality in mammograms
Authors: Raat E. M. , Kyle-Davidson C. , Evans K. K. 
Published: January 2023

AbstractExtraction of global structural regularities provides general ‘gist’ of our everyday visual environment as it does the gist of abnormality for medical experts reviewing medical images. We investigated whether naïve observers could learn this gist of medical abnormality. Fifteen participants completed nine adaptive training sessions viewing four categories of unilateral mammograms: normal, obvious-abnormal, subtle-abnormal, and global signals of abnormality (mammograms with no visible lesions but from breasts contralateral to or years prior to the development of cancer) and receiving only categorical feedback. Performance was tested pre-training, post-training, and after a week’s retention on 200 mammograms viewed for 500 ms without feedback. Performance measured as d’ was modulated by mammogram category, with the highest performance for mammograms with visible lesions. Post-training, twelve observed showed increased d’ for all mammogram categories but a subset of nine, labelled learners also showed a positive correlation of d’ across training. Critically, learners learned to detect abnormality in mammograms with only the global signals, but improvements were poorly retained. A state-of-the-art breast cancer classifier detected mammograms with lesions but struggled to detect cancer in mammograms with the global signal of abnormality. The gist of abnormality can be learned through perceptual/incidental learning in mammograms both with and without visible lesions, subject to individual differences. Poor retention suggests perceptual tuning to gist needs maintenance, converging with findings that radiologists’ gist performance correlates with the number of cases reviewed per year, not years of experience. The human visual system can tune itself to complex global signals not easily captured by current deep neural networks.
Influence of steel plates on the compressive strength and pore structure of concrete
Authors: Wang Jing , Zhang Xin 
Published: January 2023

AbstractTo accurately predict the strength of concrete in a combined structure, this paper analyzed the effect of steel plates on the pore structure and strength of concrete. Two concrete strengths and eight steel plate thicknesses were used for the experimental specimens, and their pore structures and strengths were tested at 3, 7, and 28 days. It was found that the pore structure of concrete increased with the increase in steel plate thickness. Additionally, the strength of concrete decreased with the increase in steel plate thickness. Besides, an equation was proposed to predict the strength of concrete in specimens with steel plates in this research.
Predictors of Metformin Failure: Repurposing Electronic Health Record Data to Identify High-Risk Patients
Authors: Bielinski Suzette J , Yanes Cardozo Licy L , Takahashi Paul Y , Larson Nicholas B , Castillo Alexandra , Podwika Alana , De Filippis Eleanna , Hernandez Valentina , Mahajan Gouri J , Gonzalez Crystal , Shubhangi  , Decker Paul A , Killian Jill M , Olson Janet E , St. Sauver Jennifer L , Shah Pankaj , Vella Adrian , Ryu Euijung , Liu Hongfang , Marshall Gailen D , Cerhan James R , Singh Davinder , Summers Richard L 
Published: January 2023

Abstract

Context
Metformin is the first-line drug for treating diabetes but has a high failure rate.

Objective
To identify demographic and clinical factors available in the electronic health record (EHR) that predict metformin failure.

Methods
A cohort of patients with at least 1 abnormal diabetes screening test that initiated metformin was identified at 3 sites (Arizona, Mississippi, and Minnesota). We identified 22 047 metformin initiators (48% female, mean age of 57 ± 14 years) including 2141 African Americans, 440 Asians, 962 Other/Multiracial, 1539 Hispanics, and 16 764 non-Hispanic White people. We defined metformin failure as either the lack of a target glycated hemoglobin (HbA1c) (&lt;7%) within 18 months of index or the start of dual therapy. We used tree-based extreme gradient boosting (XGBoost) models to assess overall risk prediction performance and relative contribution of individual factors when using EHR data for risk of metformin failure.

Results
In this large diverse population, we observed a high rate of metformin failure (43%). The XGBoost model that included baseline HbA1c, age, sex, and race/ethnicity corresponded to high discrimination performance (C-index of 0.731; 95% CI 0.722, 0.740) for risk of metformin failure. Baseline HbA1c corresponded to the largest feature performance with higher levels associated with metformin failure. The addition of other clinical factors improved model performance (0.745; 95% CI 0.737, 0.754, P &lt; .0001).

Conclusion
Baseline HbA1c was the strongest predictor of metformin failure and additional factors substantially improved performance suggesting that routinely available clinical data could be used to identify patients at high risk of metformin failure who might benefit from closer monitoring and earlier treatment intensification.
Clinical and Genetic Characterization of Familial Central Precocious Puberty
Authors: Tinano Flávia Rezende , Canton Ana Pinheiro Machado , Montenegro Luciana R , de Castro Leal Andrea , Faria Aline G , Seraphim Carlos E , Brauner Raja , Jorge Alexander A , Mendonca Berenice B , Argente Jesús , Brito Vinicius N , Latronico Ana Claudia 
Published: January 2023

Abstract

Context
Central precocious puberty (CPP) can have a familial form in approximately one-quarter of the children. The recognition of this inherited condition increased after the identification of autosomal dominant CPP with paternal transmission caused by mutations in the MKRN3 and DLK1 genes.

Objective
We aimed to characterize the inheritance and estimate the prevalence of familial CPP in a large multiethnic cohort; to compare clinical and hormonal features, as well as treatment response to GnRH analogs (GnRHa), in children with distinct modes of transmission; and to investigate the genetic basis of familial CPP.

Methods
We retrospectively studied 586 children with a diagnosis of CPP. Patients with familial CPP (n = 276) were selected for clinical and genetic analysis. Data from previous studies were grouped, encompassing sequencing of MKRN3 and DLK1 genes in 204 patients. Large-scale parallel sequencing was performed in 48 individuals from 34 families.

Results
The prevalence of familial CPP was estimated at 22%, with a similar frequency of maternal and paternal transmission. Pedigree analyses of families with maternal transmission suggested an autosomal dominant inheritance. Clinical and hormonal features, as well as treatment response to GnRHa, were similar among patients with different forms of transmission of familial CPP. MKRN3 loss-of-function mutations were the most prevalent cause of familial CPP, followed by DLK1 loss-of-function mutations, affecting, respectively, 22% and 4% of the studied families; both affected exclusively families with paternal transmission. Rare variants of uncertain significance were identified in CPP families with maternal transmission.

Conclusion
We demonstrated a similar prevalence of familial CPP with maternal and paternal transmission. MKRN3 and DLK1 loss-of-function mutations were the major causes of familial CPP with paternal transmission.
Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
Authors: Vanhorebeek Ilse , Gunst Jan , Casaer Michaël P , Derese Inge , Derde Sarah , Pauwels Lies , Segers Johan , Hermans Greet , Gosselink Rik , Van den Berghe Greet 
Published: January 2023

Abstract

Context
Muscle expresses and secretes several myokines that bring about benefits in distant organs.

Objective
We investigated the impact of critical illness on muscular expression of irisin, kynurenine aminotransferases, and amylase; association with clinical outcome; and impact of interventions that attenuate muscle wasting/weakness.

Methods
We studied critically ill patients who participated in 2 randomized controlled trials (EPaNIC/NESCI) and documented time profiles in critically ill mice. Included in the study were 174 intensive care unit (ICU) patients (day 8 ± 1) vs 19 matched controls, and 60 mice subjected to surgery/sepsis vs 60 pair-fed healthy mice. Interventions studied included 7-day neuromuscular electrical stimulation (NMES), and withholding parenteral nutrition (PN) in the first ICU week (late PN) vs early PN. The main outcome measures were FNDC5 (irisin- precursor), KYAT1, KYAT3, and amylase mRNA expression in skeletal muscle.

Results
Critically ill patients showed 34% to 80% lower mRNA expression of FNDC5, KYAT1, and amylases than controls (P &lt; .0001). Critically ill mice showed time-dependent reductions in all mRNAs compared with healthy mice (P ≤ .04). The lower FNDC5 expression in patients was independently associated with a higher ICU mortality (P = .015) and ICU-acquired weakness (P = .012), whereas the lower amylase expression in ICU survivors was independently associated with a longer ICU stay (P = .0060). Lower amylase expression was independently associated with a lower risk of death (P = .048), and lower KYAT1 expression with a lower risk of weakness (P = .022). NMES increased FNDC5 expression compared with unstimulated muscle (P = .016), and late PN patients had a higher KYAT1 expression than early PN patients (P = .022).

Conclusion
Expression of the studied myokines was affected by critical illness and associated with clinical outcomes, with limited effects of interventions that attenuate muscle wasting or weakness.
Combined Hypophysitis and Type 1 Diabetes Mellitus Related to Immune Checkpoint Inhibitors
Authors: Fujita Yasunori , Kamitani Fumika , Yamamoto Masaaki , Fukuoka Hidenori , Hirota Yushi , Nishiyama Nobuharu , Goda Naho , Okada Yuko , Inaba Yuiko , Nakajima Hiroki , Kurematsu Yukako , Kanie Keitaro , Shichi Hiroki , Urai Shin , Suzuki Masaki , Yamamoto Naoki , Bando Hironori , Iguchi Genzo , Suto Hirotaka , Funakoshi Yohei , Kiyota Naomi , Takahashi Yutaka , Ogawa Wataru 
Published: January 2023

Abstract

Context
The occurrence of multiple endocrinopathies due to immune checkpoint inhibitors (ICIs) is a relatively common adverse event. However, the occurrence of a combination of hypophysitis and type 1 diabetes mellitus (T1DM) is extremely rare, and its clinical features are unclear.

Objective
We comparatively analyzed the clinical features of this combination and each individual ICI-induced endocrinopathy.

Methods
We reported 3 cases that we encountered and reviewed previously reported cases of patients with combined hypophysitis and T1DM due to ICIs.

Results
Anti-programmed cell death-1 (anti-PD-1) antibodies were prescribed to all 3 cases. The duration from ICI initiation to the onset of endocrine disease was 12 to 48 weeks. Several human leukocyte antigen (HLA) haplotypes that have disease susceptibility to hypophysitis were detected in all 3 patients. With the 17 previously reported cases, combined endocrinopathies were more common in men (85%). The onset age was in the 60s for both combined and single endocrinopathies. Anti-PD-1 antibodies were used in most of the cases (90%). The time from ICI initiation to the onset of endocrinopathies was 24 (8-76) weeks for hypophysitis and 32 (8-76) weeks for T1DM in patients with combined endocrinopathies, which was not significantly different from that for each single endocrinopathy.

Conclusion
We presented 3 cases of patients with combined endocrinopathies of hypophysitis and T1DM that may have been caused by anti-PD-1 antibodies. There was no difference in the time from ICI initiation to the onset of endocrinopathies between combined and single endocrinopathies. Further case accumulation and pathogenic investigations are required.
New Diagnostic Modality Combining Mass Spectrometry and Machine Learning for the Discrimination of Malignant Intraductal Papillary Mucinous Neoplasms
Authors: Kiritani Sho , Iwano Tomohiko , Yoshimura Kentaro , Saito Ryo , Nakayama Takashi , Yamamoto Daisuke , Hakoda Hiroyuki , Watanabe Genki , Akamatsu Nobuhisa , Arita Junichi , Kaneko Junichi , Takeda Sén , Ichikawa Daisuke , Hasegawa Kiyoshi 
Published: January 2023

Abstract
Background
An intraductal papillary mucinous neoplasm (IPMN) is a pancreatic tumor with malignant potential. Although we anticipate a sensitive method to diagnose the malignant conversion of IPMN, an effective strategy has not yet been established. The combination of probe electrospray ionization-mass spectrometry (PESI-MS) and machine learning provides a promising solution for this purpose.

Methods
We prospectively analyzed 42 serum samples obtained from IPMN patients who underwent pancreatic resection between 2020 and 2021. Based on the postoperative pathological diagnosis, patients were classified into two groups: IPMN-low grade dysplasia (n = 17) and advanced-IPMN (n = 25). Serum samples were analyzed by PESI-MS, and the obtained mass spectral data were converted into continuous variables. These variables were used to discriminate advanced-IPMN from IPMN-low grade dysplasia by partial least square regression or support vector machine analysis. The areas under receiver operating characteristics curves were obtained to visualize the difference between the two groups.

Results
Partial least square regression successfully discriminated the two disease classes. From another standpoint, we selected 130 parameters from the entire dataset by PESI-MS, which were fed into the support vector machine. The diagnostic accuracy was 88.1%, and the area under the receiver operating characteristics curve was 0.924 by this method. Approximately 10 min were required to perform each method.

Conclusion
PESI-MS combined with machine learning is an easy-to-use tool with the advantage of rapid on-site analysis. Here, we show the great potential of our system to diagnose the malignant conversion of IPMN, which would be a promising diagnostic tool in clinical settings.