bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuum-kinematics-based peridynamics and phase-field approximation of non-local dynamic fracture
Authors: Partmann Kai , Wieners Christian , Weinberg Kerstin 
Published: July 2023

AbstractIn this work, two non-local approaches to dynamic fracture are investigated: a novel peridynamic formulation and a variational phase-field approach. The chosen continuum-kinematics-based peridynamic model extends the current peridynamic models by introducing surface and volume-based interactions. The phase-field fracture approach optimizes the body’s potential energy and provides a reliable method for predicting fracture in finite element computations. Both methods are able to efficiently compute crack propagation even when the cracks have arbitrary or complex patterns. We discuss the relations of critical fracture parameters in the two methods and show that our novel damage model for the continuum-kinematics-based peridynamics effectively manages fracture under dynamic loading conditions. Numerical examples demonstrate a good agreement between both methods in terms of crack propagation, fracture pattern, and in part, critical loading. We also show the limitations of the methods and discuss possible reasons for deviations.
Real-world outcomes of intravitreal bevacizumab treat-and-extend for cystoid macular oedema secondary to central retinal vein occlusion
Authors: Gildea David , Tang Bobby , Baily Caroline , Ryan Andrea 
Published: July 2023

Abstract
Introduction
The purpose of this study was to report the real-world treatment outcomes using a treat-and-extend intravitreal bevacizumab protocol in cystoid macular oedema (CMO) secondary to central retinal vein occlusion (CRVO).

Methods
We conducted a retrospective case series of consecutive adult patients with CMO secondary to CRVO who presented between 1st January 2019 and 31st December 2021. All included patients were treated with bevacizumab using a treat-and-extend protocol, were followed up for a minimum of 6 months and had a clinical examination including best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) at every visit. The primary outcome measure was mean change in BCVA.

Results
Thirty-three eyes of 33 patients were included in the study. The mean change in BCVA from baseline was + 24.5 (Median 18, SD 21.5) letters, with a mean follow-up duration of 18.5 (SD 8.9) months. The mean number of injections was 9.5 (SD 1.9) in year 1 and 7.8 (SD 2.8) in year 2. 87.9% of patients were still requiring active treatment, with a maximum interval achieved of 4-weekly in 18.2%, 6-weekly in 42.4%, 8-weekly in 6.1%, 10-weekly in 15.2%, and 12-weekly in 6.1%. The mean maximum interval achieved of those requiring ongoing treatment was 6.8 (SD 2.4) weeks. Multiple regression analyses showed that a higher baseline BCVA was negatively associated with mean visual acuity gain (P < 0.001) and positively associated with final BCVA (P < 0.001).

Conclusion
The use of intravitreal bevacizumab in a treat-and-extend regimen is effective in treating CMO secondary to CRVO, in a real-world setting.
Generalized Polarity and Weakest Constraint Qualifications in Multiobjective Optimization
Authors: Stein Oliver , Volk Maximilian 
Published: July 2023

AbstractIn Haeser and Ramos (J Optim Theory Appl, 187:469–487, 2020), a generalization of the normal cone from single objective to multiobjective optimization is introduced, along with a weakest constraint qualification such that any local weak Pareto optimal point is a weak Kuhn–Tucker point. We extend this approach to other generalizations of the normal cone and corresponding weakest constraint qualifications, such that local Pareto optimal points are weak Kuhn–Tucker points, local proper Pareto optimal points are weak and proper Kuhn–Tucker points, respectively, and strict local Pareto optimal points of order one are weak, proper and strong Kuhn–Tucker points, respectively. The constructions are based on an appropriate generalization of polarity to pairs of matrices and vectors.
Learnings from rapid response efforts to remotely detect landslides triggered by the August 2021 Nippes earthquake and Tropical Storm Grace in Haiti
Authors: Amatya Pukar , Scheip Corey , Déprez Aline , Malet Jean-Philippe , Slaughter Stephen L. , Handwerger Alexander L. , Emberson Robert , Kirschbaum Dalia , Jean-Baptiste Julien , Huang Mong-Han , Clark Marin K. , Zekkos Dimitrios , Huang Jhih-Rou , Pacini Fabrizio , Boissier Enguerran 
Published: July 2023

AbstractOn August 14, 2021, a Mw 7.2 earthquake struck the Tiburon Peninsula of western Haiti triggering thousands of landslides. Three days after the earthquake on August 17, 2021, Tropical Storm Grace crossed shallow waters offshore of southern Haiti triggering more landslides worsening the situation. In the aftermath of these events, several organizations with disaster response capabilities or programs activated to provide information on the location of landslides to first responders on the ground. Utilizing remote sensing to support rapid response, one organization manually mapped initiation point of landslides and three automatically detected landslides. The 2021 Haiti event also provided a unique opportunity to test different automated landslide detection methods that utilized both SAR and optical data in a rapid response scenario where rapid situational awareness was critical. As the methods used are highly replicable, the main goal of this study is to summarize the landslide rapid response products released by the organizations, detection methods, quantify accuracy and provide guidelines on how some of the shortcomings encountered in this effort might be addressed in the future. To support this validation, a manually mapped polygon-based landslide inventory covering the entire affected area was created and is also released through this effort.
Identification of potential DNA gyrase inhibitors: virtual screening, extra-precision docking and molecular dynamics simulation study
Authors: Kumar Avinash , Prasun Chakrawarti , Rathi Ekta , Nair Maya S. , Kini Suvarna G. 
Published: July 2023

AbstractDNA gyrase brings negative supercoils into DNA and loosens up certain positive supercoils that collect during replication and transcription and is a notable antibacterial target. To fight against the menace of antibiotic-resistant bacterial infections, we have employed various computational tools like high throughput virtual screening (HTVS), standard precision (SP) docking, extra precision (XP) docking, and molecular dynamics (MD) simulation studies to identify some potential DNA gyrase inhibitors. A focused library of 5968 anti-bacterial compounds was screened using the HTVS docking protocol of the glide module of Maestro. The top 200 docked compounds were further filtered using SP and XP docking protocols, and their free binding energies were calculated using MM-GBSA studies. The binding and stability of the top two compounds which showed better docking scores than the co-crystallized ligand (Clorobiocin) of DNA gyrase (PDB ID: 1KZN) were further probed by MD simulation of 100 ns using GROMACS. MD simulation study suggested that the compounds AM1 and AM5 form a stable complex with DNA gyrase with a good number of hydrogen bonds. XP docking study showed that interaction with the crucial amino acids for compounds AM1 and AM5 was like the co-crystallized ligand. These compounds were also predicted to be drug-like molecules with good water solubility and excellent absorption profiles. Based on the above studies, herein we report compounds AM1 (1R,3S)-1-(2-((3-(ammoniomethyl)phenyl)amino)-2-oxoethyl)-3-carbamoylpiperidin-1-ium and AM5 (1'S,2 s,4R)-4-ammonio-6-ethyl-1'-methylspiro[chromane-2,4'-piperidin]-1'-ium as potential DNA gyrase inhibitors which can be further developed as a potential lead against the menace of antibiotic resistance.
Clinical Practice Guidelines For the Management of Hepatocellular Carcinoma: A Systematic Review
Authors: Seth Ishith , Siu Adrian , Hewitt Lyndel , Budak Ulvi , Farah Beshoy , Jaber Mouhannad 
Published: July 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, including Australia. The absence of a consensus clinical practice guideline (CPG) specific to HCC management poses challenges in reducing morbidity, mortality, and improving patient recovery. This systematic review aims to evaluate the existing evidence and assess the potential of published guidelines, including those with an international scope, to provide guidance for healthcare professionals in Australia.

Methods
Electronic search of MEDLINE, Embase, Cochrane Library, Google Scholar, and PubMed was conducted. Peer-reviewed English language articles from 2005 to June 2022 were included if they described management of HCC as part of an evidence-based overall management plan or CPG. The quality of the included CPGs was assessed by the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool.

Results
Twenty-one articles from 16 regions throughout the world were included in this review. All included guidelines (n = 21, 100%) recommended evaluating cirrhosis, hepatitis B, and hepatitis C as potential risk factors of HCC. Obesity and non-alcoholic fatty liver disease were recommended by 19 CPGs (91%) as risk factor for HCC. Fourteen guidelines (67%) endorsed using the BCLC staging system. Eighteen guidelines (86%) recommended a multidisciplinary approach for the management of HCC. Eighteen guidelines (86%) advised that surveillance using ultrasound should be implemented in all cirrhotic patients every 6 months regardless of the cause of cirrhosis. AGREE II mean overall assessment score was 90% indicating that all guidelines included were highly recommended in majority of domains.

Conclusions
The included CPGs provided a comprehensive approach, emphasizing the evaluation of risk factors, utilization of the BCLC staging system, and the importance of a multidisciplinary approach. Regular surveillance using ultrasound for cirrhotic patients was widely recommended. An understanding of contemporary international CPGs can prioritize aspects of the management of HCC to assist healthcare professionals to develop a national guideline to enable standardized, comprehensive, and evidence-based care for patients with HCC.
Target Protein Expression on Tetrahymena thermophila Cell Surface Using the Signal Peptide and GPI Anchor Sequences of the Immobilization Antigen of Cryptocaryon irritans
Authors: Watanabe Yuho , Asada Masahito , Inokuchi Mayu , Kotake Maho , Yoshinaga Tomoyoshi 
Published: July 2023

AbstractCryptocaryoniasis, caused by Cryptocaryon irritans, is a significant threat to marine fish cultures in tropical and subtropical waters. However, controlling this disease remains a challenge. Fish infected with C. irritans acquires immunity; however, C. irritans is difficult to culture in large quantities, obstructing vaccine development using parasite cells. In this study, we established a method for expressing an arbitrary protein on the surface of Tetrahymena thermophila, a culturable ciliate, to develop a mimetic C. irritans. Fusing the signal peptide (SP) and glycosylphosphatidylinositol (GPI) anchor sequences of the immobilization antigen, a surface protein of C. irritans, to the fluorescent protein, monomeric Azami-green 1 (mAG1) of the stony coral Galaxea fascicularis, allowed protein expression on the surface and cilia of transgenic Tetrahymena cells. This technique may help develop transgenic Tetrahymena displaying parasite antigens on their cell surface, potentially contributing to the development of vaccines using “mimetic parasites”.
Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice
Authors: Ramírez-Carreto Ricardo J. , Zaldívar-Machorro Víctor J. , Pérez-Ramírez Dafne J. , Rodríguez-López Blanca E. , Meza Claudia , García Esperanza , Santamaría Abel , Chavarría Anahí 
Published: July 2023

AbstractParkinson’s disease (PD) is the second most frequent neurodegenerative disease associated with motor dysfunction secondary to the loss of dopaminergic neurons in the nigrostriatal axis. Actual therapy consists mainly of levodopa; however, its long-term use promotes secondary effects. Consequently, finding new therapeutic alternatives, such as neuroprotective molecules, is necessary. Among these alternatives is silybin (Sb), the major bioactive flavonolignan in silymarin. Both exert neuroprotective effects, preserving dopamine levels and dopaminergic neurons when administered in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model, being probably Sb the potential therapeutic molecule behind this effect. To elucidate the role of Sb in the PD model, we determined the dose-dependent conservation of striatal dopamine content following Sb oral administration. Then, we evaluated motor deficit tests using the best dopamine conservative dose of Sb and determined a cytokine-dependent inflammatory profile status, malondialdehyde as an oxidative stress product, and neurotrophic factors content in the MPTP-induced mouse PD model. Our results show that oral Sb at 100 mg/kg dose conserved about 60% dopamine levels. Also, Sb improved motor deficits, preserved neurotrophic factors content and mitochondrial function, reduced lipid peroxidation, diminished proinflammatory cytokines to basal levels, enhanced fractalkine production in the striatum and substantia nigra, and increased IL-10 and IL-4 levels in the substantia nigra in the MPTP mice. Thus, oral Sb may be a potential pharmacological PD treatment alternative.
Organized crime behavior of shell-company networks in procurement: prevention insights for policy and reform
Authors: Nicolás-Carlock J. R. , Luna-Pla I. 
Published: July 2023

AbstractIn recent years, the analysis of economic crime and corruption in procurement has benefited from integrative studies that acknowledge the interconnected nature of the procurement ecosystem. Following this line of research, we present a networks approach for the analysis of shell-companies operations in procurement that makes use of contracting and ownership data under one framework to gain knowledge about the organized crime behavior that emerges in this setting. In this approach, ownership and management data are used to identify connected components in shell-company networks that, together with the contracting data, allows to develop an alternative representation of the traditional buyer-supplier network: the module-component bipartite network, where the modules are groups of buyers and the connected components are groups of suppliers. This is applied to two documented cases of procurement corruption in Mexico characterized by the involvement of large groups of shell-companies in the misappropriation of millions of dollars across many sectors. We quantify the economic impact of single versus connected shell-companies operations. In addition, we incorporate metrics for the diversity of operations and favoritism levels. This paper builds into the quantitative organized crime in the private sector studies and contributes by proposing a networks approach for preventing fraud and understanding the need for legal reforms.
Does it matter who harmed whom? A cross-cultural study of moral judgments about harm by and to insiders and outsiders
Authors: McKee Paul , Kim Hyo-eun , Tang Honghong , Everett Jim A. C. , Chituc Vladimir , Gibea Toni , Marques Lucas Murrins , Boggio Paulo , Sinnott-Armstrong Walter 
Published: July 2023

AbstractThis cross-cultural study compared judgments of moral wrongness for physical and emotional harm with varying combinations of in-group vs. out-group agents and victims across six countries: the United States of America (N = 937), the United Kingdom (N = 995), Romania (N = 782), Brazil (N = 856), South Korea (N = 1776), and China (N = 1008). Consistent with our hypothesis we found evidence of an insider agent effect, where moral violations committed by outsider agents are generally considered more morally wrong than the same violations done by insider agents. We also found support for an insider victim effect where moral violations that were committed against an insider victim generally were seen as more morally wrong than when the same violations were committed against an outsider, and this effect held across all countries. These findings provide evidence that the insider versus outsider status of agents and victims does affect moral judgments. However, the interactions of these identities with collectivism, psychological closeness, and type of harm (emotional or physical) are more complex than what is suggested by previous literature.
Hyaenid remains from the Late Miocene of Kutschwan (Shanxi Province, China)
Authors: Kargopoulos Nikolaos , Kampouridis Panagiotis , Hartung Josephina , Böhme Madelaine 
Published: July 2023

AbstractThe hyaenid family reached its peak of spatial range and taxonomic diversity during the Late Miocene, including a very wide range of different forms that were spanning throughout the Old World. Particularly, the fossil record of the family in the Balkans and China has been extremely variable during that time. The present paper deals with cranial and postcranial hyaenid material from the Late Miocene locality of Kutschwan (Shanxi Province, China). The specimens were identified as Hyaenictitherium wongii, a widespread species with well-known occurrences throughout Eurasia during the Vallesian and the Turolian. The material presents some notable features, such as the enlarged M1, M2 and m2 that point towards a more basal form of the species. However, the statistical analysis of the variability of these characters points towards intraspecific divergence based on selective release, instead of taxonomically significant adaptive traits. The postcranial material conforms very well to the known material of H. wongii from other localities, indicating an agile cursorial hunter. This species is the only carnivoran found in Kutschwan, based on the current data.
The path towards increasing RAMS for novel complex missions based on CubeSat technology
Authors: Cervone A. , Topputo F. , Franzese V. , Pérez-Silva A. Rodríguez , Leon B. Benavent , Garcia B. Delmas , Minacapilli P. , Rosa P. , Bay G. , Radu S. 
Published: July 2023

AbstractThe paper presents the initial outcomes of a project, currently ongoing under the supervision of the European Space Agency, having the main objective to specify and design a Fault Detection Isolation and Recovery (FDIR) system by making use of relevant RAMS (Reliability, Availability, Maintainability, Safety) analyses for missions in non-deterministic environment with limited resources. The initial project tasks have been to select a study case represented by a CubeSat complex mission, analyse in detail both its mission and system requirements and, based on them, define a set of relevant RAMS analyses to be carried out in the second phase of the project, as inputs for the development of a FDIR concept aimed at a careful balance of the limited spacecraft resources in case of critical failures. Two possible study cases have been identified: LUMIO, a 12U CubeSat mission for the observation of micro-meteoroid impacts on the Lunar farside, and M-ARGO, a 12U deep-space CubeSat which will rendezvous with a near-Earth asteroid and characterize its physical properties for the presence of in-situ resources. Although both missions are characterized by a high level of autonomy and complexity in a harsh environment, LUMIO has been eventually selected as study case for the project. In the paper, the challenges and features of this mission are shortly presented. The specificities of the RAMS analysis and FDIR concept for this specific class of small satellite missions (including the selected study case) are highlighted in the paper, looking in particular at aspects such as the improvement of reliability while maintaining the CubeSat philosophy, the tuning of mission and system requirements in view of facilitating the design and implementation of the FDIR concept, and the current gaps within the RAMS/FDIR body of knowledge. The conclusions drawn during this first project phase provide a real view of how systems engineering must work in tandem with RAMS analyses and FDIR to achieve a more robust and functional mission architecture, thus improving the mission reliability.
Building Bridges Instead of Putting Up Walls: Connecting the “Teams” to Improve Soccer Players’ Support
Authors: Silva João Renato , Buchheit Martin , Hader Karim , Sarmento Hugo , Afonso José 
Published: July 2023

AbstractThe increase in the economic value of soccer occurred in parallel with an increase in competing demands. Therefore, clubs and federations evolved to greater specialization (e.g., state-of-the-art facilities and high-profile expertise staff) to support players’ performance and health. Currently, player preparation is far from exclusively club or national team centered, and the lack of control in each player’s environment can be more prevalent than expected. For example, an elite group of professional players faces disruptions in the season club-oriented planification due to involvement in national teams. Moreover, as elite players’ financial resources grow, it is common for them to employ specialized personal staff (e.g., strength and conditioning, nutritionist, and sports psychologist) to assist in their preparation, resulting in complex three-fold relationships (i.e., club, player’s staff, national team). Although efforts have been made to improve communication with and transition from the club to the national team supervision, this new reality (club-players’ staff) may generate serious compound role-related problems and difficulties in monitoring load and training adaptation and having a unified message. Therefore, efforts must be implemented to ensure a more informed management of the players’ performance environment, where the existence and impact of these various personal staff are considered to avoid a long-term non-zero sum for all intervening parties. If left unchecked, current professional thinking may collide or overlap, potentially triggering conflict escalation and impairing athletic performance or health, especially if effective communication routes are not adequately established. Moreover, diluted personal responsibility regarding performance may ensue, resulting in decreased productivity from all involved, which may cause more harm than benefits for the player’s overall health and performance. This emerging reality calls for developing a joint working framework (i.e., between the player’s personalized support team and the clubs’ team) and better managing of a player-centered process.
Heterogeneous spatial models in R: spatial regimes models
Authors: Piras Gianfranco , Sarrias Mauricio 
Published: July 2023

AbstractThis paper presents the progress made so far in the development of the R package hspm. The package hspm aims at implementing a variety of models and methods to control for heterogeneity in spatial models. Spatial heterogeneity can be specified in different ways, ranging from exogenous (or endogenous) spatial regimes models, to models with coefficients that potentially vary for each observations (i.e., continuous heterogeneity). We focus on a few R functions that allow for the estimation of a general spatial regimes model, as well as all of the nested specifications deriving from it. The models are estimated by instrumental variables and generalized method of moments techniques.