bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoreductive surgery for synchronous and metachronous colorectal peritoneal dissemination: Japanese P classification and peritoneal cancer index
Authors: Mizumoto Akiyoshi , Takao Nobuyuki , Imagami Toru , An Byonggu , Oe Yasumitsu , Togawa Takeshi , Yonemura Yutaka 
Published: July 2023

AbstractAimThe outcomes of cytoreductive surgery (CRS) for synchronous and metachronous colorectal peritoneal dissemination were investigated using the Japanese P classification and peritoneal cancer index (PCI).MethodsCRS was performed in 111 cases of synchronous peritoneal dissemination and 115 cases of metachronous peritoneal dissemination. The P classification and PCI were determined at the time of laparotomy.ResultsIn the synchronous dissemination group, the 5‐year overall survival rates after CRS in P1/P2 and P3 cases were 51% and 13%, respectively. Even for P3, 51% of the patients achieved macroscopic cytoreductive complete resection (CC‐0), with a 5‐year survival rate of 40%. When P3 cases were classified into PCI 0–9, 10–19, 20–29, and 30–39, CC‐0 was achieved in 93%, 70%, 6%, and 0% of the cases, respectively, and the 5‐year survival rate of PCI 0–9 was 41%. In the metachronous dissemination group, the 5‐year survival rates were 62% for PCI 0–9 and 22% for PCI 10–19; 5‐year survival was not observed in patients with a PCI ≥ 20. CC‐0 was significantly associated with the postoperative prognosis in both synchronous and metachronous peritoneal dissemination.ConclusionIn cases of synchronous dissemination, CRS must be performed for P1 and P2 cases or those with a PCI < 10, while detailed examination using PCI is required for P3 cases. In cases of metachronous dissemination, CRS should be considered when the PCI score is <20.
Synthesis of Enantioenriched 1,2‐cis Disubstituted Cycloalkanes by Convergent NiH Catalysis
Authors: Chen Changpeng , Guo Wenqing , Qiao Deyong , Zhu Shaolin 
Published: July 2023

AbstractEnantioenriched multi‐substituted cycloalkanes constitute an essential class of compounds in pharmaceuticals, natural products and agrochemicals. Here we report an NiH‐catalyzed asymmetric migratory hydroalkylation process for the efficient and selective construction of such compounds. Through a dynamic kinetic asymmetric transformation (DYKAT), easily accessible racemic and isomeric mixtures of cycloalkenes could be directly utilized as starting materials, convergently producing thermo‐dynamically disfavored chiral 1,2‐cis disubstituted cycloalkanes bearing vicinal stereocenters with high levels of regio‐, diastereo‐ and enantioselectivity. In addition, prochiral cyclic alkenes can be also employed, and deliver chiral 1,2‐cis disubstituted cycloalkanes through desymmetrization process.
Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR‐1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer
Authors: Ma Xiaoqi , Xu Midie , Zhang Xing , Wang Xin , Su Kexin , Xu Zihang , Wang Xiaoyu , Yang Yifu 
Published: July 2023

AbstractThe present study aims to investigate the mechanism of the nature compound gambogenic acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA on the proliferation of CRC cell lines were detected by MTT and clonogenic assay. The xenograft tumor model was established, and the inhibition effect of GNA were evaluated by observing the tumor growth. The endoplasmic reticulum (ER) of HCT116 was observed by using the ER tracker. The TargrtScan database was used to predict the miRNA binding sites. The level of miRNA with GNA treatment was explored by real‐time quantitative PCR. The effect of ferroptosis were evaluated by detect the expression of reactive oxygen species (ROS), intracellular ferrous iron (Fe2+), malondialdehyde (MDA), glutathione (GSH), subunit solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase (GPX)4, transferrin, and ferritin by Western blot. GNA isolated from gamboge can inhibit the growth and proliferation of CRC cell lines in a concentration‐dependent manner. GNA activated ER stress by upregulating miR‐1291, and miR‐1291 targeted the forkhead box protein A2 (FOXA2). GNA also induced ROS production and mediated the Fenton reaction by activating transferrin to increase Fe2+, thus inducing ferroptosis. In addition, GNA could induce ferroptosis through the depletion of GSH and GPX4. Furthermore, GNA treatment regulated iron metabolism by activating AMPKα/SLC7A11/GPX4 signaling. In conclusion, GNA activated ER stress via miR‐1291 and induced ferroptosis in CRC cells and might be a new inducer of ferroptosis, which can expand the efficacy of chemotherapy drugs.
Fighting calcification with optical coherence tomography‐guided percutaneous coronary intervention. Commentary on the optical coherence tomography‐derived predictors of stent expansion in calcified lesions
Authors: Sonoda Shinjo , Node Koichi 
Published: July 2023

Key Points
OCT derived coronary artery calcification assessment on requiring more aggressive lesion preparation is warranted.
The predictive ability of calcium angle, thickness, and presence of calcified nodule for absolute and relative stent expansion was limited, but only total calcium length remained a predictor.
Aggressive lesion preparation and the selection of appropriate balloon size for postdilatation under imaging guidance are necessary for fighting and overcoming calcified lesions.
Electrocautery‐assisted re‐entry to resolve bilateral aorto‐ostial chronic total occlusions due to leaflet obstruction following transcatheter aortic valve replacement
Authors: Kane Jesse , Kearney Kathleen E. , Lombardi William L. , Azzalini Lorenzo 
Published: July 2023

AbstractCoronary artery obstruction is a rare but life‐threatening complication of transcatheter aortic valve replacement (TAVR). While urgent percutaneous coronary intervention has been described in cases of acute occlusion, little is known about the interventional management of obstruction once it has occurred in the chronic setting. We describe a case in which electrocautery‐assisted re‐entry was successfully utilized to manage the right coronary artery and left main chronic total occlusion due to leaflet‐induced coronary artery obstruction after TAVR.
Bifurcation left main stenting with or without intracoronary imaging: Outcomes from the EBC MAIN trial
Authors: Maznyczka Annette , Arunothayaraj Sandeep , Egred Mohaned , Banning Adrian , Brunel Philippe , Ferenc Miroslaw , Hovasse Thomas , Wlodarczak Adrian , Pan Manuel , Schmitz Thomas , Silvestri Marc , Erglis Andrejs , Kretov Evgeny , Lassen Jens Flensted , Chieffo Alaide , Lefevre Thierry , Burzotta Francesco , Cockburn James , Darremont Olivier , Stankovic Goran , Morice Marie‐Claude , Louvard Yves , Hildick‐Smith David ,   EBC MAIN (European Bifurcation Club Left Main Coronary Stent study) investigators
Published: July 2023

AbstractBackgroundThe impact of intracoronary imaging on outcomes, after provisional versus dual‐stenting for bifurcation left main (LM) lesions, is unknown.ObjectivesWe investigated the effect of intracoronary imaging in the EBC MAIN trial (European Bifurcation Club LM Coronary Stent study).MethodsFour hundred and sixty‐seven patients were randomized to dual‐stenting or a stepwise provisional strategy. Four hundred and fifty‐five patients were included. Intravascular ultrasound (IVUS) or optical coherence tomography (OCT) was undertaken at the operator's discretion. The primary endpoint was death, myocardial infarction or target vessel revascularization at 1‐year.ResultsIntracoronary imaging was undertaken in 179 patients (39%; IVUS = 151, OCT = 28). As a result of IVUS findings, operators reintervened in 42 procedures. The primary outcome did not differ with intracoronary imaging versus angiographic‐guidance (17% vs. 16%; odds ratio [OR]: 0.92 (95% confidence interval [CI]: 0.51−1.63) p = 0.767), nor for reintervention based on IVUS versus none (14% vs. 16%; OR: 0.88 [95% CI: 0.32−2.43] p = 0.803), adjusted for syntax score, lesion calcification and ischemic symptoms. With angiographic‐guidance, primary outcome events were more frequent with dual versus provisional stenting (21% vs. 10%; adjusted OR: 2.11 [95% CI: 1.04−4.30] p = 0.039). With intracoronary imaging, there were numerically fewer primary outcome events with dual versus provisional stenting (13% vs. 21%; adjusted OR: 0.56 [95% CI: 0.22−1.46] p = 0.220).ConclusionsIn EBC MAIN, the primary outcome did not differ with intracoronary imaging versus none. However, in patients with angiographic‐guidance, outcomes were worse with a dual‐stent than provisional strategy When intracoronary imaging was used, there was a trend toward better outcomes with the dual‐stent than provisional strategy.
Recent Application and Progress of Metal Halide Perovskite Photodetector on Flexible Substrates
Authors: Li Shuigen , Xie Xiangyu , Huang Fan , Shu Lili , Liu Langyu , Wang Chasheng , Yang Yong , Li Rong 
Published: July 2023

Comprehensive SummaryIn recent years, flexible photodetectors (FPDs) have received increasing attention due to their applications in electronic eyes, flexible sensing, terminal devices, and wearable devices. In addition, metallic halide perovskite materials are considered as future materials for FPDs due to their compatibility with flexible substrates, low cost, simple synthesis methods, and superior optoelectronic properties. This review provides a comprehensive overview of the relevant cutting‐edge research in the field of flexible perovskite photodetectors (FPPDs) from 2020 to 2022. First, the evaluation criteria for FPPDs are discussed and the development of perovskite stability criteria is emphatically described. Afterwards, the synthesis methods and device construction processes of metal halide perovskite materials commonly used by researchers in the past three years are described. These include single crystals and low‐dimensional materials. Moreover, we have elaborated on the research of self‐powered FPPD and its contributions in wearability, terminals, and portability. Finally, a summary of developments and possibilities in the field of FPPDs from 2020 to 2022 is provided.
Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis
Authors: Wang Yu , Pu Xuehua , Zhu Zhiyun , Sun Wenbin , Xue Lu , Ye Jilu 
Published: July 2023

AbstractBackgroundReduced muscular strength is common in patients with heart failure (HF). The aim of the systematic review and meta‐analysis was to evaluate the association between handgrip strength (HGS) and prognosis of patients with HF.HypothesisReduced HGS may be a risk factor of poor prognosis of patients with HF.MethodsRelevant observational studies with longitudinal follow‐up were obtained by a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. A random‐effects model was used to pool the results.ResultsFifteen studies involving 7350 patients with HF were included in the meta‐analysis. Pooled results showed that HF patients with lower HGS were associated with a higher risk of mortality during follow‐up (risk ratio [RR]: 2.00, 95% confidence interval [CI]: 1.55–2.58, p < .001; I2 = 0%). Subgroup analysis showed that the association was not significantly affected by characteristics such as study country, design, mean age of the patients, HF status (stable or advanced/acute), HF type (reduced or preserved ejection fraction), follow‐up duration, and quality score (p for subgroup difference all > 0.05). Further analysis showed that per 1 kgf decrease of HGS was associated with an 8% increased risk of mortality during follow‐up (RR: 1.08, 95% CI: 1.05–1.11, p < .001; I2 = 12%). Moreover, HF patients with lower HGS were also related to a higher risk of composite outcome of HF rehospitalization or mortality (RR: 1.67, 95% CI: 1.19–2.35, p = .003; I2 = 53%).ConclusionA low HGS may be associated with poor clinical outcomes of patients with HF.
Quantifying seasonal, depression focused recharge in the context of public supply well vulnerability
Authors: Wiebe Andrew J. , Menkveld Paul G. , Rudolph David L. 
Published: July 2023

AbstractDepression focused recharge (DFR) may be a hydrologically important process that impacts the vulnerability of public supply wells, specifically related to pathogenic contaminants. The nature of DFR in glacial moraine environments, such as those located in northern latitudes within North America and Europe, is less well established than in other regions such as the Prairie Pothole Region (Northern United States, Western Canada) and the High Plains Aquifer (Central United States). The objectives of this study were to quantify seasonal infiltration flux beneath a topographically‐closed depression within 50 m of a public supply well and to interpret the impact of this DFR process on well vulnerability. Field instruments including groundwater monitoring wells, pressure transducers, soil moisture sensors and temperature sensors were installed in vertical clusters to capture the dynamics of infiltration, drainage and recharge within the depression feature. Continuous weather data were recorded by a meteorological station at the site. Transient infiltration was quantified during two contrasting hydrological events. The first event (~2 days) was an intense rainfall (>50 mm) on a melting snowpack during the fall season when the soils were unfrozen. The second was a longer (35 day) period during the spring freshet when the surficial soils were initially frozen and subject to diurnal freezing and thawing and occasional precipitation events. The water table fluctuation method augmented by Darcy flux contributions, in addition to numerical modelling using the HYDRUS‐1D model, were used to quantify recharge rates beneath the depression. Numerical DFR estimates and analytical results differed by ±8%. Results indicate that recharge rates on the order of the annual regional average can occur beneath localized features in response to extreme events associated with snowmelt and intense rainfall. Such events may represent a microbial threat to groundwater quality if public supply wells are located nearby.
CXCL13 variant predicts pegylated‐interferon α treatment response in HBeAg‐positive chronic hepatitis B patients
Authors: Luo Mengqi , Zhang Lingyan , Yang Chou , Zhou Bin , Hou Jinlin , Jiang De‐Ke 
Published: July 2023

AbstractAs a key immune cytokine, C‐X‐C motif chemokine ligand 13 (CXCL13) has been reported to play critical roles in immune control of hepatitis B virus (HBV) infection. We aimed to screen single‐nucleotide polymorphisms (SNPs) of CXCL13 for predicting response to pegylated interferon‐alpha (PegIFNα) therapy of chronic hepatitis B (CHB) patients. Two independent cohorts with a total of 945 (Cohort 1, n = 238; Cohort 2, n = 707) hepatitis B e antigen (HBeAg)‐positive CHB patients treated with PegIFNα were enrolled in this retrospective cohort study. Eight candidate SNPs were selected through gene‐wide SNP mining within or flanking CXCL13. A polygenic score (PGS) was utilized to assess the cumulative effects of multiple SNPs. The associations of candidate SNPs and PGS with combined response (CR, defined as the combination of HBeAg seroconversion and HBV DNA level <3.3log10 IU/mL) and hepatitis B surface antigen (HBsAg) level were evaluated. Among the eight candidate SNPs, rs76084459 which is located at upstream of CXCL13 was significantly associated with both CR (p = 0.002) and HBsAg level (p = 0.015). A PGS integrating CXCL13_rs76084459 and five other SNPs, which were previously identified as predictors of PegIFNα treatment response, was further strongly correlated with CR (p = 1.759 × 10−10) and HBsAg level (p = 0.004). This study demonstrated that CXCL13_rs76084459 can predict response to PegIFNα treatment of HBeAg‐positive CHB patients. A PGS composed of six SNPs including CXCL13_rs76084459 predicts PegIFNα treatment response better.
Winter heat waves characteristics associated with downslope windstorm in south Brazil
Authors: da Rosa Cinara Ewerling , Stefanello Michel , dos Reis Nicolle Cordero Simões , Facco Douglas Stefanello , Teleginski Ferraz Simone , Boiaski Nathalie Tissot , Herdies Dirceu Luis , Degrazia Gervásio Annes 
Published: July 2023

AbstractThe air temperature anomaly was analysed in 16 consecutive winters from 2004 to 2019 in southern Brazil using reanalysis data and hourly atmospheric observations. In this study, 13 heat wave (HW) episodes were identified using the percentile methodology. All identified episodes are associated with the occurrence of a downslope windstorm known as Vento Norte (VNOR; Portuguese for ‘North Wind’). The VNOR is characterized by a sharp increase in air temperature combined with constant, strong, gusty winds from the north and a drop in relative humidity. The average duration was about 5 days for HW and 18 h for VNOR being than in 59.5% of the HW hours, the VNOR windstorm was also detected. The main atmospheric variables were compared during the periods of winter, HW and the VNOR windstorm. The analysis showed that HW alters local weather and climate conditions, with the more pronounced features associated with the VNOR flow. A more detailed investigation comparing the atmospheric variables collected north and south of an abrupt change in terrain altitude (400 m) revealed that the main cause of the amplification of the atmospheric variable anomalies in the centre of the state of Rio Grande do Sul was the simultaneous occurrence of HW and VNOR.
Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems
Authors: Di Luca Mariagrazia , Poursani Ensieh , Curcio Manuela , Cirillo Giuseppe , Salerno Antonietta , Bolognini Sara , De Filpo Giovanni , Filippi Sara , Vittorio Orazio , Iemma Francesca , Nicoletta Fiore Pasquale 
Published: July 2023

AbstractWith the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC‐5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g−1 for blank and hybrid hydrogels, respectively) and an electro‐responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin‐resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB.
Technical note: System uncertainty on four‐ and eight‐channel parallel RF transmission for safe MRI of deep brain stimulation devices
Authors: Yang Benson , Chen Chih‐Hung , Graham Simon J. 
Published: July 2023

AbstractBackgroundParallel radiofrequency transmission (pTx) remains a promising technology for addressing high‐field magnetic resonance imaging (MRI) challenges, particularly regarding the safety of patients with implanted deep brain stimulation (DBS) devices. Radiofrequency (RF) shim optimization methods utilizing pTx technology have shown the potential to minimize induced RF heating effects at the electrode tips of DBS devices at 3 T.PurposeResearch pTx system implementations often involve the combination of custom and commercial hardware that are integrated onto an existing MRI system. As a result, system characterization is important to ensure implant‐friendly safe imaging conditions are satisfied for the operating range of the hardware.MethodsUtilizing electromagnetic and thermal simulations, the impact of system uncertainty is studied for the proposed 4‐ and 8‐channel pTx system setup and its associated “safe mode” for DBS applications.ResultsElectromagnetic simulations indicated that instrumentation errors can affect the overall electric field strength experienced at the DBS lead tip, and a worst‐case system uncertainty analysis predicted temperature elevations of +1.5°C in the 4‐channel setup and +0.9°C in the 8‐channel setup.ConclusionsIn conclusion, system uncertainty can impact the precision of pTx RF inputs which in the worst‐case, may lead to an unsafe imaging scenario and the proposed 8‐channel setup may provide more robustness and thus, safer conditions for MRI of DBS patients.
Hearing Loss and Sociodemographic Barriers to Health Care Access Using the All of Us Research Program
Authors: Cortina Luis E. , Amini Andrew , Benson Jalen , Huang Victoria W. , Naples James G. 
Published: July 2023

AbstractObjectiveTo explore how gender and low‐income status independently influence general health care access in patients with hearing loss.Study DesignCross‐sectional study.SettingNational database.MethodsPatients with a diagnosis of sensorineural hearing loss from the National Institutes of Health All of Us database were included. Data entered from May 2018 to November 2022 was analyzed. Patient demographics such as age, gender, educational level, and insurance status were assessed. Multivariate logistic regressions were performed for statistical evaluation.ResultsA subset of 8875 patients (48.3% male, mean age 69) were evaluated. After multivariate analysis, female participants were more likely than male participants to report difficulty affording prescribed medications (odds ratio [OR]: 1.7, p < .0005) and specialists (OR: 1.4, p < 0.005). Female patients were also more likely to delay care due to elder care responsibilities (OR: 2.6, p < .0005), employment obligations (OR: 1.7, p < .0005), and feelings of apprehension in seeing a provider (OR: 1.7, p < .0005). Finally, female participants reported feeling less likely to be involved in their own medical care compared to males (OR: 1.2, p < .005). Low‐income (<$25,000) participants reported less likely to feel respected (OR: 3.2, p < .0005) and delivered understandable health information (OR: 2.3, p < .0005) by providers compared to participants of higher income.ConclusionThis work suggests that patients with hearing loss, female gender, and lower socioeconomic status independently introduce barriers to health care access and utilization. These factors should be considered in efforts to promote equity in the care of patients with hearing loss.