bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor
Authors: Otter Maarten , Campforts Bea C. M. , Stumpel Constance T. R. M. , van Amelsvoort Thérèse A. M. J. , Drukker Marjan 
Published: December 2022

Abstract

Background
Women with triple X syndrome (TXS) have an extra X chromosome. TXS appeared to be associated with psychiatric disorders in biased or underpowered studies.

Aim
This study aims to describe the prevalence of psychiatric disorders in adults with TXS in a relatively large and less biased group of participants.

Method
In this cross-sectional study, data were collected from 34 women with TXS (mean age = 32.9; s.d. = 13.1) and 31 controls (mean age = 34.9; s.d. = 13.7). Psychiatric disorders were assessed using the MINI International Neuropsychiatric Interview (MINI) and the adult behavior checklist (ABCL). Trait and state anxiety were assessed using the State–Trait Anxiety Inventory.

Results
In the TXS group, MINI results showed a higher prevalence of major depressive episodes (43.3%), psychotic disorders (29.4%), and suicidality (23.5%). Only 50% of the TXS group earned a normal score for the total syndrome score using the ABCL. In addition, levels of trait anxiety were higher in the TXS group. Only three women in each group received psychotropic medication. Impaired social functioning appeared to represent a major risk factor in TXS as regards psychotic, affective disorders, trait anxiety, and low self-esteem.

Conclusions
Women with TXS are vulnerable to developing psychiatric disorders, and women with both TXS and impaired social functioning are even more vulnerable.
Identifying Nonpatient Authors of Patient Portal Secure Messages in Oncology: A Proof-of-Concept Demonstration of Natural Language Processing Methods
Authors: Benda Natalie C. , Rogers Christopher , Sharma Mohit , Narain Wazim , Diamond Lisa C. , Ancker Jessica , Seier Kenneth , Stetson Peter D. , Sulieman Lina , Armstrong Misha , Peng Yifan 
Published: December 2022

PURPOSE Patient portal secure messages are not always authored by the patient account holder. Understanding who authored the message is particularly important in an oncology setting where symptom reporting is crucial to patient treatment. Natural language processing has the potential to detect messages not authored by the patient automatically. METHODS Patient portal secure messages from the Memorial Sloan Kettering Cancer Center were retrieved and manually annotated as a predicted unregistered proxy (ie, not written by the patient) or a presumed patient. After randomly splitting the annotated messages into training and test sets in a 70:30 ratio, a bag-of-words approach was used to extract features and then a Least Absolute Shrinkage and Selection Operator (LASSO) model was trained and used for classification. RESULTS Portal secure messages (n = 2,000) were randomly selected from unique patient accounts and manually annotated. We excluded 335 messages from the data set as the annotators could not determine if they were written by a patient or proxy. Using the remaining 1,665 messages, a LASSO model was developed that achieved an area under the curve of 0.932 and an area under the precision recall curve of 0.748. The sensitivity and specificity related to classifying true-positive cases (predicted unregistered proxy-authored messages) and true negatives (presumed patient-authored messages) were 0.681 and 0.960, respectively. CONCLUSION Our work demonstrates the feasibility of using unstructured, heterogenous patient portal secure messages to determine portal secure message authorship. Identifying patient authorship in real time can improve patient portal account security and can be used to improve the quality of the information extracted from the patient portal, such as patient-reported outcomes.
Improved gauge-unfixing formalism through a prototypical second-class system
Authors: Ananias Neto J. , Morais W. D. , Thibes R. 
Published: December 2022

Abstract
We contextualize the improved gauge-unfixing (GU) formalism within a rather general prototypical second-class system, obtaining a corresponding first-class equivalent description enjoying gauge invariance which can be applied to several situations. The prototypical system is chosen to represent a considerable class of relevant models in field theory. By considering the improved version of the GU formalism, we show that any gauge-invariant function can be obtained in terms of a specific deformation in phase space, benefiting thus from the fact that no auxiliary variables are needed in the process. In this way, the resulting converted first-class system is constructed out of the same original canonical variables, preserving the number of degrees of freedom. We illustrate the technique with an application to the nonlinear sigma model.
Instantaneous tunneling of relativistic massive spin-0 particles
Authors: Flores Philip Caesar , Galapon Eric A. 
Published: December 2022

Abstract
The tunneling time problem studied earlier in Phys. Rev. Lett., 108 (2012) 170402, using a non-relativistic time-of-arrival (TOA) operator predicted that tunneling time is instantaneous. This raises the question whether instantaneous tunneling time is a consequence of using a non-relativistic theory. Here, we extend the analysis by proposing a formalism on the construction of relativistic TOA operators for spin-0 particles in the presence of an interaction potential V (q) via quantization. We then construct the corresponding barrier traversal time operator, and impose the condition that the barrier height V

o
is less than the rest mass energy of the particle. We show that only the above-barrier energy components of the incident wavepackets momentum distribution contribute to the barrier traversal time while the below-barrier components are transmitted instantaneously.
Boosting thermodynamic performance by bending space-time
Authors: Ferketic Emily E. , Deffner Sebastian 
Published: December 2022

Abstract
Black holes are arguably the most extreme regions of the universe. Yet, they are also utterly inaccessible to experimentation, and even just indirect observation poses significant technical challenges. The phenomenological approach of thermodynamics is uniquely suited to explore at least some of the physical properties of such scenarios, and this has motivated the study of so-called holographic engines. We show that the efficiency of an endoreversible Brayton cycle is given by the Curzon-Ahlborn efficiency, if the engine is fueled by a 2-dimensional ideal gas; and that the efficiency is higher, if the working medium is a (2 + 1)-dimensional BTZ black hole. These findings may be relevant not only in the quest to unlock the mysteries of black holes, but also for potential technological applications of graphene.
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies’ Section of Peripheral Nerve Surgery
Authors: Rochkind Shimon , Ferraresi Stefano , Denisova Natalia , Garozzo Debora , Heinen Christian , Alimehmeti Ridvan , Capone Crescenzo , Barone Damiano G. , Zdunczyk Anna , Pedro Maria T. , Antoniadis Gregor , Kaiser Radek , Dubuisson Annie , Pondaag Willem , Kretschmer Thomas , Rasulic Lukas , Dengler Nora F. 
Published: December 2022

BACKGROUND:
In the first part of this report, the European Association of Neurosurgical Societies' section of peripheral nerve surgery presented a systematic literature review and consensus statements on anatomy, classification, and diagnosis of thoracic outlet syndrome (TOS) along with a subclassification system of neurogenic TOS (nTOS). Because of the lack of level 1 evidence, especially regarding the management of nTOS, we now add a consensus statement on nTOS treatment among experienced neurosurgeons.

OBJECTIVE:
To document consensus and controversy on nTOS management, with emphasis on timing and types of surgical and nonsurgical nTOS treatment, and to support patient counseling and clinical decision-making within the neurosurgical community.

METHODS:
The literature available on PubMed/MEDLINE was systematically searched on February 13, 2021, and yielded 2853 results. Screening and classification of abstracts was performed. In an online meeting that was held on December 16, 2021, 14 recommendations on nTOS management were developed and refined in a group process according to the Delphi consensus method.

RESULTS:
Five RCTs reported on management strategies in nTOS. Three prospective observational studies present outcomes after therapeutic interventions. Fourteen statements on nonsurgical nTOS treatment, timing, and type of surgical therapy were developed. Within our expert group, the agreement rate was high with a mean of 97.8% (± 0.04) for each statement, ranging between 86.7% and 100%.

CONCLUSION:
Our work may help to improve clinical decision-making among the neurosurgical community and may guide nonspecialized or inexperienced neurosurgeons with initial patient management before patient referral to a specialized center.
Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning
Authors: Kameyama Akiyo , Asai Hirotaka , Nomoto Masanori , Ohno Shuntaro , Ghandour Khaled , Ohkawa Noriaki , Saitoh Yoshito , Yamazaki Mitsuaki , Inokuchi Kaoru 
Published: December 2022

ABSTRACT
General anesthesia could induce amnesia, however the mechanism remains unclear. We hypothesized that suppression of neuronal ensemble activity in the hippocampus by anesthesia during the post-learning period causes retrograde amnesia. To test this hypothesis, two experiments were conducted with sevoflurane anesthesia (2.5%, 30 min): a hippocampus-dependent memory task, the context pre-exposure facilitation effect (CPFE) procedure to measure memory function and in vivo calcium imaging to observe neural activity in hippocampal CA1 during context exploration and sevoflurane/home cage session. Sevoflurane treatment just after context pre-exposure session impaired the CPFE memory, suggesting sevoflurane induced retrograde amnesia. Calcium imaging showed sevoflurane treatment prevented neuronal activity in CA1. Further analysis of neuronal activity with non-negative matrix factorization, which extracts neural ensemble activity based on synchronous activity, showed that sevoflurane treatment reduced the reactivation of neuronal ensembles between during context exploration just before and one day after sevoflurane inhalation. These results suggest that sevoflurane treatment immediately after learning induces amnesia, resulting from suppression of reactivation of neuronal ensembles.
Impacts and mechanisms of CO2 narcosis in bumble bees: narcosis depends on dose, caste and mating status and is not induced by anoxia
Authors: Cressman Anna , Amsalem Etya 
Published: December 2022

ABSTRACT
Carbon dioxide (CO2) is commonly used to immobilize insects and to induce reproduction in bees. However, despite its wide use and potential off-target impacts, its underlying mechanisms are not fully understood. Here, we used Bombus impatiens to examine whether CO2 impacts are mediated by anoxia and whether these mechanisms differ between female castes or following mating in queens. We examined the behavior, physiology and gene expression of workers, mated queens and virgin queens following exposure to anoxia, hypoxia, full and partial hypercapnia, and controls. Hypercapnia and anoxia caused immobilization, but only hypercapnia resulted in behavioral, physiological and molecular impacts in bees. Recovery from hypercapnia resulted in increased abdominal contractions and took longer in queens. Additionally, hypercapnia activated the ovaries of queens, but inhibited those of workers in a dose-dependent manner and caused a depletion of fat-body lipids in both castes. All responses to hypercapnia were weaker following mating in queens. Analysis of gene expression related to hypoxia and hypercapnia supported the physiological findings in queens, demonstrating that the overall impacts of CO2, excluding virgin queen ovaries, were unique and were not induced by anoxia. This study contributes to our understanding of the impacts and the mechanistic basis of CO2 narcosis in insects and its impacts on bee physiology.
This article has an associated ECR Spotlight interview with Anna Cressman.
Sperm calcium flux and membrane potential hyperpolarization observed in the Mexican big-eared bat Corynorhinus mexicanus
Authors: Mendoza-Sánchez José Edwin , Rodríguez-Tobón Ahiezer , Arenas-Ríos Edith , Orta-Salazar Gerardo J. , León-Galván Miguel A. , Treviño Santa Cruz Claudia L. , Chávez Julio C. 
Published: December 2022

ABSTRACT
Mammalian sperm capacitation involves biochemical and physiological changes, such as an increase in intracellular calcium ion concentration ([Ca2+]i), hyperpolarization of the plasma membrane potential and sperm hyperactivation, among others. These changes provide sperm with the ability to fertilize. In the bat Corynorhinus mexicanus, there is an asynchrony between spermatogenesis and sperm storage in the male with the receptivity of the female. For instance, in C. mexicanus, spermatogenesis occurs before the reproductive season. During the reproductive period, sperm are stored in the epididymis for a few months and the testis undergoes a regression, indicating low or almost null sperm production. Therefore, it is unclear whether the elements necessary for sperm fertilization success undergo maturation or preparation during epididymis storage. Here, we characterized pH-sensitive motility hyperactivation and Ca2+ influx in sperm, regulated by alkalinization and progesterone. In addition, by electrophysiological recordings, we registered currents that were stimulated by alkalinization and inhibited by RU1968 (a CatSper-specific inhibitor), strongly suggesting that these currents were evoked via CatSper, a sperm Ca2+-specific channel indispensable for mammalian fertilization. We also found hyperpolarization of the membrane potential, such as in other mammalian species, which increased according to the month of capture, reaching the biggest hyperpolarization during the mating season. In conclusion, our results suggest that C. mexicanus sperm have functional CatSper and undergo a capacitation-like process such as in other mammals, particularly Ca2+ influx and membrane potential hyperpolarization.
Intratumoral and peritumoral radiomics for preoperatively predicting the axillary non-sentinel lymph node metastasis in breast cancer on the basis of contrast-enhanced mammography: a multicenter study
Authors: Lin Fan , Li Qin , Wang Zhongyi , Shi Yinghong , Ma Heng , Zhang Haicheng , Zhang Kun , Yang Ping , Zhang Ran , Duan Shaofeng , Gu Yajia , Mao Ning , Xie Haizhu 
Published: December 2022

Objective: To develop and test a contrast-enhanced mammography (CEM)-based radiomics model using intratumoral and peritumoral regions to predict non-sentinel lymph node (NSLN) metastasis in breast cancer before surgery. Methods: This multicenter study included 365 breast cancer patients with sentinel lymph node metastasis. Intratumoral regions of interest (ROIs) were manually delineated, and peritumoral ROIs (5 and 10 mm) were automatically obtained. Five models, including intratumoral model, peritumoral (5 and 10 mm) models, and intratumoral+peritumoral (5 and 10 mm) models, were constructed by support vector machine classifier on the basis of optimal features selected by variance threshold, SelectKbest, and least absolute shrinkage and selection operator algorithms. The predictive performance of radiomics models was evaluated by receiver operating characteristic curves. An external testing set was used to test the model. The Memorial Sloan Kettering Cancer Center (MSKCC) model was used to compare the predictive performance with radiomics model. Results: The intratumoral ROI and intratumoral+peritumoral 10-mm ROI-based radiomics model achieved the best performance with an area under the curve (AUC) of 0.8000 (95% confidence interval [CI]: 0.6871–0.8266) in the internal testing set. In the external testing set, the AUC of radiomics model was 0.7567 (95% CI: 0.6717–0.8678), higher than that of MSKCC model (AUC = 0.6681, 95% CI: 0.5148–0.8213) (p = 0.361). Conclusions: The intratumoral and peritumoral radiomics based on CEM had an acceptable predictive performance in predicting NSLN metastasis in breast cancer, which could be seen as a supplementary predicting tool to help clinicians make appropriate surgical plans. Advances in knowledge: The intratumoral and peritumoral CEM-based radiomics model could noninvasively predict NSLN metastasis in breast cancer patients before surgery.
Anti-angiogenic effect of the combination of low-dose sorafenib and EGCG in HCC-induced Wistar rats
Authors: Irawan Andry , Prabowo Erik , Riwanto Ignatius , Atmodjo Wahyuni Lukita 
Published: December 2022

Background: Sorafenib is a standard drug used for advanced hepatocellular carcinoma but is often resistant and toxic. Its combination with epigallo-3-catechin gallate leads to reduced resistance and toxicity but an equally effective anti-angiogenic effect.Therefore, this study aims to assess the anti-angiogenic effect of standard-dose Sorafenib compared to the combination of low-dose Sorafenib and epigallo-3-catechin gallate. Methods: We conducted an animal study and double-blind, randomized controlled trials. A total of 25 male Wistar rats (7 weeks old) were randomly divided into four groups, namely Sham (K), Control (O), a combination of low-dose Sorafenib and epigallo-3-catechin gallate group (X1), and standard-dose Sorafenib group (X2). All groups were injected with N-Nitrosodiethylamine 70 mg/kg body weight (BW) intraperitoneally for ten weeks, except the Sham group. After the development of hepatocellular carcinoma, X1 and X2 were treated for two weeks. Subsequently, liver tissues and tumor masses were examined for vascular endothelial growth factor (VEGF) level and microvascular density expression. Results: There was a significant difference (p=0.007) in the level of VEGF between group X1 (low dose Sorafenib + EGCG) and X2 (Standard dose Sorafenib). However, the differences in VEGF levels of group X1 and X2 compared to group O(Control) were significantly lower, with values p=0.000136 and p=0.019, respectively. The expression of microvascular density between groups X1 and X2 was not entirely different. Meanwhile, a significant difference (p<0.05) was discovered when both groups were compared with the control group. Conclusion: The combination of low-dose Sorafenib with epigallo-3-catechin gallate is superior in reducing the level of VEGF compared to standard-dose Sorafenib and is better than the control. Standard-dose Sorafenib and the combination of low-dose Sorafenib and epigallo-3-catechin gallate have similar effectivity in reducing the expression of microvascular density and could prevent resistance and lower toxicity effects.
Effectiveness of Gatekeeper Training Program (GTP) on awareness, attitude, mental help seeking intention and gatekeeper behavior among Koraga tribe: A study protocol
Authors: Noronha Flavia Sharlet , Jose Tessy Treesa , George Anice , George Linu Sara 
Published: December 2022

Aim: This study aims to build the capacity of the people at grass root level as gatekeepers of mental health. It will assess the effectiveness of the Gatekeeper Training Program (GTP) on gatekeeper behaviour, awareness, attitude, and mental help seeking intention. Design: An evaluative research approach in two phases. Phase 1: Cross-sectional house-to-house exploratory survey. Phase 2: A quasi-experimental design with multiple follow ups at 0, 6 and 12 months. Method: Data will be collected using standardized tools like Mental Health Knowledge Questionnaire (MHKQ), Community Attitude towards Mentally Ill (CAMIS), Mental Help Seeking Intention (MHSIS) and Gatekeeper Behavior Scale (GBS). For Phase 1, a house-to-house survey will be conducted among the selected colonies of Koraga tribe to determine their awareness, attitude, and mental help seeking intention regarding common mental health problems. Phase 2 includes identification of the leaders/representatives of the selected tribal colonies, and involving them in GTP. Pre-test and multiple post-test will be conducted in Phase 2 at 0, 6, 12 months. The study is funded by Indian Council of Medical Research from 16 August 2021 for 3 years duration. Discussion: Treatment gap in psychiatric disorders remains an issue of great concern. Evidence based research promotes task shifting approaches in dealing with mental health problems in the community. Capacity building programs like GTP for the underprivileged section of the society are important especially in low and middle income group of countries. Impact: This need based GTP, will ensure mental health first aid in the society. Early identification of people with mental health problems at their doorsteps has huge impact on the prognosis of the illness, closing the treatment gap and stigma reduction.
Bottlenecks and opportunities towards achieving the targeted 95-95-95 HIV services in a rural district in Eastern Uganda
Authors: Samuel Namenkere Monkya , Mary Stella Ayaa , Linda Sukuku , Juliet Kharono , Charles Mugabi , Benina Chelangat , Abwola Olwedo Mary , Nabasumba Carol , Oboth Paul , Osele Julius , Nekaka Rebecca , Iramiot Jacob Stanley 
Published: December 2022

Background: Uganda has made progress in reducing its HIV prevalence from 7.3% in 2011 to 6% in 2017, however, more needs to be done to meet the World Health Organization (WHO) target of 95% of the population knowing their HIV status, 95% enrolled on treatment and 95% achieving viral suppression. This study aimed to assess the bottlenecks and opportunities towards achieving the 95 95 95 targeted HIV services in the Bukedea district. Methods: A mixed-methods cross-sectional study was conducted in the Bukedea district covering males and females aged 18-65 years who had consented to participate in the study. We used a purposive sampling procedure to select our study participants. Qualitative data was collected through focus group discussions, key informant interviews, and document reviews for quantitative data. Quantitative data were analyzed using STATA v 14 whereas qualitative data were analyzed using the thematic analysis approach. Results: The challenges were grouped as patient-related, medication-related, and facility-related. The patient-related challenges were stigma, fear of taking the medication, poor nutrition, long distances, alcoholism, busy working schedules, and domestic violence. The medication-related challenges were side effects and pill burden. The facility-related challenges were inadequate pretest counseling and stock-outs. The use of anti-retroviral drugs (ART) was common in piggery and poultry and the sources of these drugs were reported to be the people on ART and the health workers. The opportunities included home-based counseling, organizing more outreaches, counseling and health education, targeted testing, and strengthening the Village Health Teams (VHT) networks. Conclusions: The study revealed that the major challenges towards achieving the targeted 95-95-95 HIV services were stigma, inadequate pre-test counseling, fear of disclosure, and poor adherence due to alcoholism, sharing of drugs with animals and partners. The use of anti-retroviral drugs in animal husbandry was common in the Bukedea District.