bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating The Efficacy Of Endotracheal Epinephrine Administration At Standard Versus High Dose During Resuscitation Of Severely Asphyxiated Newborn Lambs: A Randomized Preclinical Study
Authors: Polglase Graeme R. , Brian Yoveena , Tantanis Darcy , Blank Douglas A. , Badurdeen Shiraz , Crossley Kelly J. , Kluckow Martin , Gill Andrew W. , Camm Emily , Galinsky Robert , Songstad Nils Thomas , Klingenberg Claus , Hooper Stuart B. , Roberts Calum T. 
Published: March 2023

AbstractBackgroundEpinephrine treatment is recommended during neonatal resuscitation, if ventilation and chest compressions are ineffective. Endotracheal administration is an option, if the preferred intravenous route is unavailable. We aimed to determine the efficacy of endotracheal epinephrine for achieving return of spontaneous circulation (ROSC), and maintaining physiological stability after ROSC, at standard and higher dose, in severely asphyxiated newborn lambs.MethodsNear-term fetal lambs were instrumented for physiological monitoring, and asphyxiated until asystole. Resuscitation was commenced with ventilation and chest compressions as per ILCOR recommendations. Lambs were randomly allocated to: IV Saline placebo (5 ml/kg, n=6), IV Epinephrine (20 micrograms/kg, n=9), Standard-dose ET Epinephrine (100 micrograms/kg, n=9), and High-dose ET Epinephrine (1 mg/kg, n=9). After three allocated treatment doses, rescue IV Epinephrine was administered if ROSC had not occurred. Lambs achieving ROSC were ventilated and monitored for 60 minutes before euthanasia. Brain histology was assessed for micro-hemorrhage.ResultsROSC in response to allocated treatment (without rescue IV Epinephrine) occurred in 1/6 Saline, 9/9 IV Epinephrine, 0/9 Standard-dose ET Epinephrine, and 7/9 High-dose ET Epinephrine lambs respectively. Three Saline, six Standard-dose ET Epinephrine, and one High-dose ET Epinephrine lambs achieved ROSC after rescue IV Epinephrine. Blood pressure during CPR increased after treatment with IV Epinephrine and High-dose ET Epinephrine, but not Saline or Standard-dose ET Epinephrine.After ROSC, both ET Epinephrine groups had lower pH, higher lactate, and higher blood pressure than the IV Epinephrine group. Cortex micro-hemorrhage was more frequent in the High-dose ET Epinephrine lambs (8/8 lambs examined, versus 3/8 in IV Epinephrine lambs).ConclusionsThe currently recommended dose of ET Epinephrine was ineffective in achieving ROSC. In the absence of convincing clinical or preclinical evidence of efficacy, use of ET Epinephrine at this dose may not be appropriate.High-dose ET Epinephrine requires further evaluation before clinical translation.
Heat inactivation of foetal bovine serum causes protein contamination of extracellular vesicles
Authors: Urzì Ornella , Moschetti Marta , Lässer Cecilia , Johansson Junko , D’Arrigo Daniele , Olofsson Bagge Roger , Crescitelli Rossella 
Published: March 2023

ABSTRACTBoth the release of extracellular vesicles (EVs) in cell cultures and the cargo that these EVs carry can be influenced by cell culture conditions such as the presence of foetal bovine serum (FBS). Although several studies have evaluated the effect of removing FBS-derived EVs by ultracentrifugation (UC), less is known about the influence of FBS heat inactivation on the cell-derived EVs. To assess this, three protocols based on different combinations of EV depletion by UC and heat inactivation were evaluated, including FBS that was ultracentrifuged but not heat-inactivated, FBS that was heat inactivated before EV depletion, and FBS that was heat inactivated after EV depletion. The FBS samples were then added to the culture media of three melanoma cell lines, and after 72 h both large and small EVs were isolated by differential UC. We demonstrated by transmission electron microscopy, protein measurement, and quantification of the number of particles that heat inactivation performed after EV depletion reduced the purity of small EVs but had no effect on large EV purity. Quantitative mass spectrometry analysis of FBS-derived small EVs showed that the EV protein content was different when FBS was heat inactivated after EV depletion compared to EVs isolated from FBS that was not heat inactivated or that was heat inactivated prior to EV depletion. Moreover, several of the quantified proteins were wrongly attributed to be of human origin because the EVs were of obvious bovine origin. Our results demonstrated that proteins of bovine origin coming from FBS-derived EVs could mistakenly be attributed to human cell-derived EVs in EV proteomic studies. Moreover, we concluded that heat inactivation performed after EV depletion induced the release of proteins that might contaminate EV samples, and the recommendation is therefore to always perform heat inactivation prior to EV depletion.
Extending the servicescape conceptualization: accounting for perceptions of crowding and risks under the pandemic
Authors: Nath Atanu Kumar , Saha Parmita , Mei Xiang Ying 
Published: March 2023

Purpose
Though many conceptual and empirical studies have been conducted on the servicescape, limited research has focused on how the COVID-19 pandemic has reshaped factors influencing the servicescape. This paper aims to propose an extension of Bitner’s original conceptualization, including pandemic-induced physical and social constraints on servicescape in the form of crowding, consumer risk perception during the crisis and their impact on consumers' and employees’ behavioral changes in retail and hospitality sectors.

Design/methodology/approach
This paper critically reviewed the past and emerging servicescape and risk literature. It then examines and delineates the concepts of crowding, density and associated risk perceptions to offer an extended servicescape framework. Alongside, scales were proposed to measure the constructs and guidelines given to conduct future empirical studies.

Findings
This paper discussed the major impact on servicescape during a pandemic situation, to what extent risk is perceived during consumption and the impact of crowding and store density on employee and customer behavioral responses.

Research limitations/implications
This paper principally contributes by explicitly including specific risk dimensions and crowding and proposes the scales to measure consumers’ understanding of pandemic-induced perceptions of risk, crowding and density within servicescapes for further empirical testing. Alongside this, the identification and concretization of different types of perceived risks under COVID-19 provide critical and useful marketing implications.

Originality/value
This study identifies relevant risk dimensions, proposes crowding as an independent construct apart from servicescape physicality and proposes relevant measures for empirical verification.
Contractor payment delays: a systematic review of current trends and future directions
Authors: Adaku Ebenezer , Osei-Poku Victor , Ottou Jemima Antwiwaa , Yirenkyi-Fianko Adwoa 
Published: March 2023

Purpose
The phenomenon of delayed payment to contractors, particularly in the construction industry, is a vital one and has implications for the health of economies of both developing and developed countries. However, the knowledge of this phenomenon seems patchy and scattered. This paper aims to provide a comprehensive overview of the knowledge on the subject matter with directions for future research.

Design/methodology/approach
A systematic literature review coupled with a scientometric analysis was used to identify the main strands of delayed payment to contractor research as a basis for qualitative analysis and directions for future investigations.

Findings
Current trends of delayed payment to contractor research are categorised into five broad themes, namely: causes, effects, mitigation measures, ethical and law and regulatory issues. On the basis of these themes, directions for future research are proffered.

Originality/value
To the best of the authors knowledge, this is the first attempt at providing a comprehensive and an integrated knowledge on delayed payment to contractor research with pointers for further investigation and policy directions.
Determination of the space-dependent blood perfusion coefficient in the thermal-wave model of bio-heat transfer
Authors: Alosaimi M.A. , Lesnic D. 
Published: March 2023

PurposeWhen modeling heat propagation in biological bodies, a non-negligible relaxation time (typically between 15-30 s) is required for the thermal waves to accumulate and transfer, i.e. thermal waves propagate at a finite velocity. To accommodate for this feature that is characteristic to heat transfer in biological bodies, the classical Fourier's law has to be modified resulting in the thermal-wave model of bio-heat transfer. The purpose of the paper is to retrieve the space-dependent blood perfusion coefficient in such a thermal-wave model of bio-heat transfer from final time temperature measurements.Design/methodology/approachThe non-linear and ill-posed blood perfusion coefficient identification problem is reformulated as a non-linear minimization problem of a Tikhonov regularization functional subject to lower and upper simple bounds on the unknown coefficient. For the numerical discretization, an unconditionally stable direct solver based on the Crank–Nicolson finite difference scheme is developed. The Tikhonov regularization functional is minimized iteratively by the built-in routine lsqnonlin from the MATLAB optimization toolbox. Both exact and numerically simulated noisy input data are inverted.FindingsThe reconstruction of the unknown blood perfusion coefficient for three benchmark numerical examples is illustrated and discussed to verify the proposed numerical procedure. Moreover, the proposed algorithm is tested on a physical example which consists of identifying the blood perfusion rate of a biological tissue subjected to an external source of laser irradiation. The numerical results demonstrate that accurate and stable solutions are obtained.Originality/valueAlthough previous studies estimated the important thermo-physical blood perfusion coefficient, they neglected the wave-like nature of heat conduction present in biological tissues that are captured by the more accurate thermal-wave model of bio-heat transfer. The originalities of the present paper are to account for such a more accurate thermal-wave bio-heat model and to investigate the possibility of determining its space-dependent blood perfusion coefficient from temperature measurements at the final time.
Mapping the desktop research in Pakistan: a bibliometric analysis
Authors: Wahid Nazia , Amin Usama , Khan Muhammad Ajmal , Siddique Nadeem , Warraich Nosheen Fatima 
Published: March 2023

Purpose
This study aims to map the “Desktop Research” (DR) output in Pakistan, as part of the growing field of research globally. It also ascertains the productive institutions and prolific authors along with their collaboration patterns.

Design/methodology/approach
Bibliometric techniques were used to quantitatively analyze the DR published in Pakistan. The publications from 1981 to 2021 were retrieved from Scopus. A total of 1,802 publications were retrieved and used for analysis.

Findings
Results indicated an unpredictable increase in DR output from approximately 100 to 400 records during the past five years. The year 2020 was most productive in DR research showing the excess use of secondary data by researchers in COVID-19. The focus of researchers towards DR was consistently rising. Medical journals were found to publish DR extensively. Majority of the publications were contributed by collaborative work and researchers of the USA were found as the most collaborative with Pakistani authors. Publications of single category journals, open access journals and international collaboration get more citations.

Research limitations/implications
The results of the analysis rely only on a single database, Scopus, for retrieving the publication data.

Practical implications
The study has practical implications for the policymakers and higher education development organizations to introduce the DR as a course in academic schools.

Originality/value
To the best of the authors’ knowledge, this study is the first to review DR in the context of Pakistan through bibliometric analysis. This comprehensive overview provides a better understanding of the development of the field and possible practice implications.
iStage: a deep learning based framework to determine the stage of disaster management cycle from a social media message
Authors: Singla Annie , Agrawal Rajat 
Published: March 2023

Purpose
This study aims to propose iStage, i.e. an intelligent hybrid deep learning (DL)-based framework to determine the stage of the disaster to make the right decisions at the right time.

Design/methodology/approach
iStage acquires data from the Twitter platform and identifies the social media message as pre, during, post-disaster or irrelevant. To demonstrate the effectiveness of iStage, it is applied on cyclonic and COVID-19 disasters. The considered disaster data sets are cyclone Fani, cyclone Titli, cyclone Amphan, cyclone Nisarga and COVID-19.

Findings
The experimental results demonstrate that the iStage outperforms Long Short-Term Memory Network and Convolutional Neural Network models. The proposed approach returns the best possible solution among existing research studies considering different evaluation metrics – accuracy, precision, recall, f-score, the area under receiver operating characteristic curve and the area under precision-recall curve.

Originality/value
iStage is built using the hybrid architecture of DL models. It is effective in decision-making. The research study helps coordinate disaster activities in a more targeted and timely manner.
Information processing of food safety messages: what really matters for restaurant customers?
Authors: Shafieizadeh Kiyan , Alotaibi Salman , Tao Chen-Wei (Willie) 
Published: March 2023

Purpose
This study aims to examine how customers’ perceptions of the quality and credibility of restaurants’ food safety information influence customers’ information adoption and, consequently, their trust in the restaurant and purchase intention. It also explores the moderating effects of customers’ food safety knowledge and health consciousness.

Design/methodology/approach
Participants were asked to read a food safety message from a chain restaurant’s website before taking a self-administered online survey. Using a cross-sectional design, a total of 526 valid responses were collected in the USA through Amazon Mechanical Turk. A two-step approach consisting of a measurement model and a structural equation model was applied to test the direct and indirect effects. Additionally, hierarchical regression models were developed to test the moderating effects.

Findings
Results show that perceived information quality significantly affects perceived information credibility and has a significant direct and indirect influence on information adoption. Furthermore, information adoption has a direct positive influence on customers’ trust in the restaurant and an indirect effect on purchase intention (full mediation effect of trust). Finally, the moderation effects of health consciousness and food safety knowledge were supported.

Practical implications
Restaurateurs can apply research findings to increase the likelihood that customers adopt their food safety information and to enhance customers’ trust and, consequently, purchase intention in restaurants.

Originality/value
Reflecting on framing theory and information processing theory, this study examines the ways that customers process restaurants’ food safety information by developing an original conceptual framework with strong empirical data support.
Is this time the same? Housing market performance during SARS and COVID-19*
Authors: Lu Siru , Wang Chongyu , Wong Siu Kei , Shi Shuai 
Published: March 2023

Purpose
This paper aims to examine the housing market responses to two outbreaks of respiratory diseases in Hong Kong during the Information Era – the 2003 SARS and COVID-19 outbreaks.

Design/methodology/approach
The authors first investigate the aggregate housing price changes during SARS and COVID-19. Next, the authors conduct a battery of univariate analyses pertaining to the relationship between district-level housing price movements and geographic and demographic patterns during the pandemic periods. Finally, to shed light on the housing price dynamics at the micro level, the authors conduct an estate-level analysis with the data of 234 residential estates from 2003 to 2020, focusing on the impacts of SARS and COVID-19 on the idiosyncratic volatility of residential estates.

Findings
Overall, SARS and COVID-19 outbreaks are negatively associated with housing prices. However, unlike SARS, the impact of COVID-19 on housing prices was moderate and transient. The geographic imbalances of the epidemic-induced underperformance are observed at the district and estate levels. Finally, the estate-level analysis presented in this paper indicates that the average idiosyncratic volatility of residential estates is 1.5% higher during the SARS period but 3.7% lower during the COVID-19 period. Lower volatility during COVID-19 is likely explained by household learning from the SARS period.

Practical implications
Regulators and investors could resort to efficient information disclosure to attenuate idiosyncratic volatility's adverse impact on housing market returns.

Originality/value
To the best of the authors’ knowledge, the authors are among the first to examine housing market responses to the 2003 SARS and COVID-19 outbreaks using the Hong Kong housing market as a laboratory.
Board diversity on firm performance from resource-based view perspective: new evidence from Pakistan
Authors: Khan Ismail , Khan Iftikhar , Khan Ikram Ullah , Suleman Shahida , Ali Shoukat 
Published: March 2023

PurposeThis study aims to investigate the impact of extensive board diversity on firm performance from the perspective of resource-based view (RBV) theory in the context of Pakistan.Design/methodology/approachThe analyses are made using a panel random-effects model and generalized method of moment (GMM) across 188 non-financial firms listed in the Pakistan Stock Exchange (PSX) over the period of 2009–2020. The robustness of findings is checked through alternative measurements of the variables and alternative estimation techniques.FindingsThe results show that board members' nationality, ethnicity and educational level diversities are significantly positively related to firm performance. In contrast, age and educational background diversities negatively affect firm performance. However, gender and tenure diversities have an insignificant relationship with firm performance.Research limitations/implicationsThis study is conducted in the context of Pakistani firms; thus, the findings may not be generalizable to other economies because different economies have different institutional settings and governance structures.Practical implicationsThe policy-makers should encourage the inclusion of board members' nationality, ethnicity and educational level diversities having relevant educational backgrounds to improve firms' competitive performance. The suggested structure of the corporate board may improve firm performance by attracting multiple stakeholders and fulfilling their expectations.Social implicationsThe appointment of a director should be based on merit rather than on political connections or personnel relationships to improve social welfare and avoid their negative impact on firm competitive performance.Originality/valueTo the best of the authors' knowledge, this is the first study that investigates the impact of board diversity on firm accounting-based performance and market-based performance in the emerging economy of Pakistan. This study uses RBV theory to provide a unique corporate governance structure based on board diversity, particularly in Pakistan.
Nexus between entrepreneurial orientation and intellectual capital
Authors: Chaudhary Sanjay , Dhir Amandeep , Farronato Nicola , Nicotra Melita , Pironti Marco 
Published: March 2023

PurposeThe importance of knowledge-based assets and the capability to leverage them has been the subject of scholarly interest in entrepreneurial orientation literature. The authors attempt to understand the dominant themes in the prior literature and propose directions for future research.Design/methodology/approachThe authors performed a systematic review of 79 studies to answer the research questions: (1) What are the predominant themes in the literature on the role of intellectual capital and entrepreneurial orientation? (2) What are the potential fields of future research?FindingsThe findings suggest that current research engages the topics of intellectual capital, the capability to leverage knowledge assets and entrepreneurial orientation. The thematic analysis reveals the role of knowledge management, organizational learning, intellectual capital and absorptive capacity in entrepreneurial firms. The authors propose a theoretical model to explain how intellectual capital and its management influence firm-level entrepreneurial behavior.Originality/valueUnderstanding the association between intellectual capital and the capability to leverage knowledge assets is crucial in a dynamic business environment. Effective deployment of knowledge is vital while searching for new entrepreneurial opportunities.
A bibliometric analysis and assessment of container terminal operations research
Authors: Dragović Branislav , Zrnić Nenad , Tzannatos Ernestos , Kosanić Nenad , Dragović Andro 
Published: March 2023

PurposeThe paper undertakes a bibliometric analysis and assessment of journal publications in the field of container terminal operations research (CTOR), in an attempt to identify high-impact papers (HIPs) published in Science Citation Index/Social Science Citation Index (SCI/SSCI) journals of CTOR subject category from 1973 to 2020.Design/methodology/approachA structured approach for identifying the HIPs is developed based on the utilization of bibliometric and network analyses.FindingsThe CTOR papers are assessed in terms of publication outputs, distribution of outputs in SCI/SSCI journals, authorship, institutions and countries, as well as citation life cycles of papers with the highest total citations since their publication until the year 2020. The results show that between 1989 and 2015, there were 82 HIPs in the field of CTOR, which have been cited at least 200 times, with more than 50% of these citations allocated in the second part of paper citation life cycle according to the database of Google Scholar.Practical implicationsThe practical implication of the aforementioned reviewing and assessing journal publications of CTOR is that it offers the ability to reveal the tone of its development through addressing main characteristics of the relevant HIPs as determined by the highly cited papers in this field of research.Originality/valueThis paper offers a unique analysis and assessment in the field of CTOR by identifying the relevant HIPs and their associated scientific actors (authors, institutions and countries), thus facilitating the future research effort in the field of CTOR.