bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soziale Teilhabe und Hautkrebs während der COVID-19-Pandemie
Authors: Niewolik Jacqueline , Mikuteit Marie , Schröder Dominik , Heinemann Stephanie , Heesen Gloria , Müller Frank , Dopfer-Jablonka Alexandra , Grimmelmann Imke , Steffens Sandra 
Published: January 2023

Zusammenfassung
Hintergrund
Die getroffenen Maßnahmen zur Eindämmung der Ausbreitung der Coronavirus-2019-Erkrankung (COVID-19) schränken die sozialen Teilhabemöglichkeiten vieler Menschen ein. Insbesondere Menschen mit chronischen Erkrankungen waren hiervon betroffen. Ziel dieser Beobachtungsstudie war die Untersuchung der sozialen Teilhabe bei Patient:innen mit fortgeschrittenem malignem Melanom mit Immuntherapie unter Pandemiebedingungen. Damit wurde erstmalig soziale Teilhabe als Endpunkt in einer sehr spezifischen Gruppe untersucht. Dies kann als Basis für folgende Studien im wachsenden Kollektiv von Tumorlangzeitüberlebenden in Pandemiezeiten verstanden werden.

Methodik
Querschnittuntersuchung von Melanompatient:innen mit Erhebung des Index zur Messung von Einschränkungen der Teilhabe (IMET). Ergebnisse werden mit publizierten Normdaten verglichen.

Ergebnisse
Es wurden 47 Patient:innen mit malignem Melanom in der Auswertung berücksichtigt. Sie waren im Mittel 58,5 Jahre (SD 13,2) alt, 18 Patient:innen befanden sich im Stadium III und erhielten eine adjuvante Immuntherapie; 29 Patient:innen wurden wegen eines metastasierten Melanoms (Stadium IV) behandelt. Die Ergebnisse des IMET ergaben im Gesamtscore keine signifikanten Einschränkungen der sozialen Teilhabe im Vergleich zu den publizierten vorpandemischen Normdaten. Teilnehmerinnen hatten jedoch eine signifikant eingeschränktere Teilhabe.

Diskussion
Der Endpunkte soziale Teilhabe rückt bei Langzeitüberlebenden mit malignem Melanom in den Vordergrund. Unter Pandemiebedingungen sind insbesondere Patientinnen von Einschränkungen der sozialen Teilhabe gefährdet. Eine Differenzierung zwischen Pandemieeinflüssen und erkrankungsspezifischen Faktoren geht aus unseren Daten nicht hervor. Ausgehend von dieser Studie können und sollten weitere Erhebungen zur sozialen Teilhabe in Zeiten von pandemischen Infektionserkrankungen, insbesondere im wachsenden Kollektiv onkologischer Langzeitüberlebender erfolgen.

Graphic abstract
A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe
Authors: Marx-Stoelting P. , Rivière G. , Luijten M. , Aiello-Holden K. , Bandow N. , Baken K. , Cañas A. , Castano A. , Denys S. , Fillol C. , Herzler M. , Iavicoli I. , Karakitsios S. , Klanova J. , Kolossa-Gehring M. , Koutsodimou A. , Vicente J. Lobo , Lynch I. , Namorado S. , Norager S. , Pittman A. , Rotter S. , Sarigiannis D. , Silva M. J. , Theunis J. , Tralau T. , Uhl M. , van Klaveren J. , Wendt-Rasch L. , Westerholm E. , Rousselle C. , Sanders P. 
Published: January 2023

AbstractCurrent approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.
Multielectrode recordings of cockroach antennal lobe neurons in response to temporal dynamics of odor concentrations
Authors: Tichy Harald , Martzok Alexander , Linhart Marlene , Zopf Lydia M. , Hellwig Maria 
Published: January 2023

AbstractThe initial representation of the instantaneous temporal information about food odor concentration in the primary olfactory center, the antennal lobe, was examined by simultaneously recording the activity of antagonistic ON and OFF neurons with 4-channel tetrodes. During presentation of pulse-like concentration changes, ON neurons encode the rapid concentration increase at pulse onset and the pulse duration, and OFF neurons the rapid concentration decrease at pulse offset and the duration of the pulse interval. A group of ON neurons establish a concentration-invariant representation of odor pulses. The responses of ON and OFF neurons to oscillating changes in odor concentration are determined by the rate of change in dependence on the duration of the oscillation period. By adjusting sensitivity for fluctuating concentrations, these neurons improve the representation of the rate of the changing concentration. In other ON and OFF neurons, the response to changing concentrations is invariant to large variations in the rate of change due to variations in the oscillation period, facilitating odor identification in the antennal-lobe. The independent processing of odor identity and the temporal dynamics of odor concentration may speed up processing time and improve behavioral performance associated with plume tracking, especially when the air is not moving.
Wet bias of summer precipitation in the northwestern Tibetan Plateau in ERA5 is linked to overestimated lower-level southerly wind over the plateau
Authors: Ou Tinghai , Chen Deliang , Tang Jianping , Lin Changgui , Wang Xuejia , Kukulies Julia , Lai Hui-Wen 
Published: January 2023

AbstractThe Tibetan Plateau (TP), also called the Third Pole, is considered to be “the world water tower”. The northwestern TP (NWTP), which has an average elevation higher than 4800 m, is an arid region where the summer precipitation is largely overestimated by the ERA5 global reanalysis product. We hypothesize that this wet bias is mainly caused by unrealistic lower-level winds that trigger strong convection over the region; it can be reduced by using a high-resolution regional climate model with a large domain that allows realistically representing interactions between the Westerlies and Asian summer monsoons. Here, downscaling using the Weather Research and Forecasting (WRF) model driven by ERA5 was conducted with a large domain (8°‒50° N, 65°‒125° E) at 9 km for the period 1979‒2019 (WRF9km). Precipitation values from WRF9km and ERA5 were evaluated against satellite observations; compared with ERA5, WRF9km captured the climatological summer precipitation over the NWTP with a much-reduced wet bias. The ERA5 overestimation is mainly caused by excessive convective precipitation, likely linked to strong vertical motions over the NWTP induced by an overestimated lower-level southerly wind.
Kyanite petrogenesis in migmatites: resolving melting and metamorphic signatures
Authors: Phillips Stacy E. , Argles Tom W. , Warren Clare J. , Harris Nigel B. W. , Kunz Barbara E. 
Published: January 2023

AbstractAluminosilicates (kyanite, sillimanite and andalusite) are useful pressure–temperature (P–T) indicators that can form in a range of rock types through different mineral reactions, including those that involve partial melting. However, the presence of xenocrystic or inherited grains may lead to spurious P–T interpretations. The morphologies, microtextural positions, cathodoluminescence responses and trace element compositions of migmatite-hosted kyanite from Eastern Bhutan were investigated to determine whether sub-solidus kyanite could be distinguished from kyanite that crystallised directly from partial melt, or from kyanite that grew peritectically during muscovite dehydration reactions. Morphology and cathodoluminescence response were found to be the most reliable petrogenetic indicators. Trace element abundances generally support petrographic evidence, but protolith bulk composition exerts a strong control over absolute element abundance in kyanite. Sample-normalised concentrations show distinctive differences between petrogenetic types, particularly for Mg, Ti, V, Cr, Mn, Fe and Ge. LA-ICP-MS element maps, particularly combined to show Cr/V, provide additional information about changing geochemical environments during kyanite growth. Most kyanite in the studied migmatitic leucosomes is of sub-solidus origin, with less widespread evidence for peritectic crystallisation. Where present, grain rims commonly crystallised directly from the melt; however, entire grains crystallised exclusively from melt are rare. The presence of kyanite in leucosomes does not, therefore, necessarily constrain the P–T conditions of melting, and the mechanism of growth should be determined before using kyanite as a P–T indicator. This finding has significant implications for the interpretation of kyanite-bearing migmatites as representing early stages of melting during Himalayan evolution.
Effects of a microgravity SkinSuit on lumbar geometry and kinematics
Authors: Breen Alexander , Carvil Philip , Green David Andrew , Russomano Thais , Breen Alan 
Published: January 2023

Abstract
Purpose
Astronauts returning from long ISS missions have demonstrated an increased incidence of lumbar disc herniation accompanied by biomechanical and morphological changes associated with spine elongation. This research describes a ground-based study of the effects of an axial compression countermeasure Mk VI SkinSuit designed to reload the spine and reduce these changes before return to terrestrial gravity.

Methods
Twenty healthy male volunteers aged 21–36 without back pain participated. Each lay overnight on a Hyper Buoyancy Flotation (HBF) bed for 12 h on two occasions 6 weeks apart. On the second occasion participants donned a Mk VI SkinSuit designed to axially load the spine at 0.2 Gz during the last 4 h of flotation. Immediately after each exposure, participants received recumbent MRI and flexion–extension quantitative fluoroscopy scans of their lumbar spines, measuring differences between spine geometry and intervertebral kinematics with and without the SkinSuit. This was followed by the same procedure whilst weight bearing. Paired comparisons were performed for all measurements.

Results
Following Mk VI SkinSuit use, participants evidenced more flexion RoM at L3–4 (p = 0.01) and L4–5 (p = 0.003), more translation at L3–4 (p = 0.02), lower dynamic disc height at L5–S1 (p = 0.002), lower lumbar spine length (p = 0.01) and greater lordosis (p = 0.0001) than without the Mk VI SkinSuit. Disc cross-sectional area and volume were not significantly affected.

Conclusion
The MkVI SkinSuit restores lumbar mobility and lordosis following 4 h of wearing during hyper buoyancy flotation in a healthy control population and may be an effective countermeasure for post space flight lumbar disc herniation.
Identification of seven hypoxia-related genes signature and risk score models for predicting prognosis for ovarian cancer
Authors: Huang Yan , Zhou Yuqi , Zhang Meiqin 
Published: January 2023

Abstract
Ovarian cancer (OC) is the most common malignant cancer in the female reproductive system. Hypoxia is an important part of tumor immune microenvironment (TIME), which is closely related to cancer progression and could significantly affect cancer metastasis and prognosis. However, the relationship between hypoxia and OC remained unclear. OCs were molecularly subtyped by consensus clustering analysis based on the expression characteristics of hypoxia-related genes. Kaplan–Meier (KM) survival was used to determine survival characteristics across subtypes. Immune infiltration analysis was performed by using Estimation of Stromal and Immune cells in Malignant Tumors using Expression data (ESTIMATE) and microenvironment cell populations-counter (MCP-Counter). Differential expression analysis was performed by using limma package. Next, univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses were used to build a hypoxia-related risk score model (HYRS). Mutational analysis was applied to determine genomic variation across the HYRS groups. The Tumor Immune Dysfunction and Exclusion (TIDE) algorithm was used to compare the effectiveness of HYRS in immunotherapy prediction. We divided OC samples into two molecular subtypes (C1 and C2 subtypes) based on the expression signature of hypoxia genes. Compared with C1 subtype, there was a larger proportion of poor prognosis genotypes in the C2 subtype. And most immune cells scored higher in the C2 subtype. Next, we obtained a HYRS based on 7 genes. High HYRS group had a higher gene mutation rate, such as TP53. Moreover, HYRS performed better than TIDE in predicting immunotherapy effect. Combined with clinicopathological features, the nomogram showed that HYRS had the greatest impact on survival prediction and a strong robustness.
Third-Generation Sirolimus‐Eluting Bioresorbable Tyrocore Scaffold Implantation in Patients with ST‐Segment Elevation Myocardial Infarction: Baseline and 6-Month OCT and Clinical Outcomes—a FANTOM STEMI Pilot Study
Authors: Koltowski Lukasz , Tomaniak Mariusz , Ochijewicz Dorota , Opolski Grzegorz , Kochman Janusz 
Published: January 2023

Abstract
Purpose
The aim of this study was to evaluate the safety and efficacy of the Fantom BRS 6 months after implantation using the optical coherence tomography (OCT) imaging.

Methods
Twenty STEMI patients treated with a sirolimus‐eluting Fantom BRS were enrolled into a prospective, single-arm, serial observational study. The scaffold sizing, positioning and optimisation were guided by OCT imaging. The primary endpoint was device‐orientated composite endpoints (DOCE), comprised of cardiac death, target-vessel-related myocardial infarction and target lesion failure. To evaluate the device performance at the scaffold level, we performed a quantitative coronary angiography (QCA) and OCT imaging at 6 months.

Results
The primary endpoint did not occur in any patient within the 6-month follow‐up. There were no major adverse cardiac events (MACEs) or DOCEs, no cases of scaffold thrombosis, target lesion revascularization and no deaths. In QCA, we observed a decrease in the minimum and mean lumen diameter in the in-scaffold region and in the proximal and distal peri-scaffold region. Similarly, the minimum lumen area and reference vessel diameter had decreased in both QCA and OCT. The OCT imaging showed improvement in the expansion index and malposition rate.

Conclusion
A serial 6-month OCT imaging after implantation of a third-generation Tyrocore-based bioresorbable coronary scaffold indicated good coverage of the struts with excellent healing of the scaffold, low neointima growth and no signs of neoatherosclerosis.
Autistic Adults Show Intact Learning on a Visuospatial Serial Reaction Time Task
Authors: Treves Isaac N. , Cannon Jonathan , Shin Eren , Li Cindy E. , Bungert Lindsay , O’Brien Amanda , Cardinaux Annie , Sinha Pawan , Gabrieli John D. E. 
Published: January 2023

AbstractSome theories have proposed that autistic individuals have difficulty learning predictive relationships. We tested this hypothesis using a serial reaction time task in which participants learned to predict the locations of a repeating sequence of target locations. We conducted a large-sample online study with 61 autistic and 71 neurotypical adults. The autistic group had slower overall reaction times, but demonstrated sequence-specific learning equivalent to the neurotypical group, consistent with other findings of typical procedural memory in autism. The neurotypical group, however, made significantly more prediction-related errors early in the experiment when the stimuli changed from repeated sequences to random locations, suggesting certain limited behavioural differences in the learning or utilization of predictive relationships for autistic adults.
Maternal Prenatal Distress, Maternal Pre- and Postnatal Bonding and Behavioral and Emotional Problems in Toddlers. A Secondary Analysis of the IRIS Study
Authors: Henrichs Jens , de Kroon Marlou , Walker Annika , Witteveen Anke , Westerneng Myrte , van Baar Anneloes , de Jonge Ank 
Published: January 2023

AbstractMaternal prenatal distress (i.e., anxiety and depressive symptoms) increases the risk for childhood behavioral and emotional problems. So far, the potential role of maternal bonding in this association still needs further study. Maternal prenatal distress can affect the development of maternal bonding from pregnancy onwards. Maternal prenatal and postnatal bonding in turn have been shown to predict child behavioral functioning. We aimed to investigate whether maternal prenatal and postnatal bonding mediate the association between maternal prenatal distress and toddlers’ internalizing and externalizing problems. Data from a Dutch prospective longitudinal sample (N = 666) were used to conduct single and multiple mediation models. Mothers reported prenatal anxiety (State Anxiety Inventory) and prenatal depressive symptoms (Edinburgh Postnatal Depression Scale) at 24 weeks’ gestation and maternal prenatal bonding (Maternal Antenatal Attachment Scale) at 32 weeks’ gestation. At 6 weeks and 6 months postpartum mothers completed questionnaires to assess maternal postnatal bonding (Maternal Postnatal Attachment Scale). Mothers reported child internalizing and externalizing problems (Child Behavior Checklist) at 28 months postpartum. Maternal prenatal and postnatal bonding mediated the link between maternal prenatal anxiety and child externalizing problems but not internalizing problems. Only maternal bonding 6 months postpartum mediated the link between maternal prenatal depressive symptoms and child internalizing problems but not externalizing problems. Our study showed that maternal postnatal bonding more consistently mediated links between measures of maternal prenatal distress and child behavioral and emotional problems than maternal prenatal bonding. Interventions reducing maternal prenatal distress and promoting maternal bonding should be developed.
Elucidating the pressure-induced enhancement of ionic conductivity in sodium closo-hydroborate electrolytes for all-solid-state batteries
Authors: Huang Yuanye , Černý Radovan , Battaglia Corsin , Remhof Arndt 
Published: January 2023

AbstractHydroborates are an emerging class of solid electrolytes for all-solid-state batteries. Here, we investigate the impact of pressure on the crystal structure and ionic conductivity of a close-hydroborate salt consisting of Na2B10H10 and Na2B12H12. Two Na2B10H10:Na2B12H12 ratios were studied, 1:1 and 1:3. The anions of the as-synthesized powder with 1:1 ratio crystallize in a single face-centered cubic phase, while the anions of the powder with 1:3 ratio crystallize in a single monoclinic phase. After applying pressure to densify the powder into a pellet, a partial phase transformation into a body-centered cubic (BCC) phase is observed for both ratios. The BCC content saturates at 50 weight percent (wt%) at 500 MPa for the 1:1 ratio and at 77 wt% at 1000 MPa for the 1:3 sample. The room temperature sodium-ion conductivity follows an analogous trend. For the 1:1 ratio, it increases from 2 × 10–4 Scm−1 at 10 wt% BCC content to about 1.0 × 10–3 Scm−1 at 50 wt% BCC content. For the 1:3 ratio, it increases from 1.3 × 10–5 Scm−1 at 11.9 wt% BCC to 8.1 × 10–4 Scm−1 at 71 wt% BCC content. Our results show that pressure is a prerequisite to achieve high sodium-ion conductivity by formation of the highly conductive BCC phase.
Assessing the applicability of 19F labeled tryptophan residues to quantify protein dynamics
Authors: Krempl Christina , Sprangers Remco 
Published: January 2023

AbstractNuclear magnetic resonance (NMR) spectroscopy is uniquely suited to study the dynamics of biomolecules in solution. Most NMR studies exploit the spins of proton, carbon and nitrogen isotopes, as these atoms are highly abundant in proteins and nucleic acids. As an alternative and complementary approach, fluorine atoms can be introduced into biomolecules at specific sites of interest. These labels can then be used as sensitive probes for biomolecular structure, dynamics or interactions. Here, we address if the replacement of tryptophan with 5-fluorotryptophan residues has an effect on the overall dynamics of proteins and if the introduced fluorine probe is able to accurately report on global exchange processes. For the four different model proteins (KIX, Dcp1, Dcp2 and DcpS) that we examined, we established that 15N CPMG relaxation dispersion or EXSY profiles are not affected by the 5-fluorotryptophan, indicating that this replacement of a proton with a fluorine has no effect on the protein motions. However, we found that the motions that the 5-fluorotryptophan reports on can be significantly faster than the backbone motions. This implies that care needs to be taken when interpreting fluorine relaxation data in terms of global protein motions. In summary, our results underscore the great potential of fluorine NMR methods, but also highlight potential pitfalls that need to be considered.
Exploring product/service innovation process in UK: university spin-offs from practice-based lens
Authors: Baines Ning , Klangboonkrong Te , Smith Helen Lawton 
Published: January 2023

AbstractIn this study, we explore the product/service innovation process in university spin-offs (USOs) – a category of micro/small firms operating at the edge of technological frontiers. Our approach reconciles the traditional linear model with a practice-based lens, which characterises firm learning processes as underpinned by two logics of production and development. The findings agree with the extant literature that the process overall does not always follow stages in a standardised model. The lens further suggests that the interplay between the two logics occurs even within an individual so-called stage of the linear model, which makes for a counter-intuitive observation. This interplay also hinges upon customer collaboration and feedback. Overall, the apparent lack of adherence to formal process in USOs innovation is not mere haphazard response to being small and new. Reconciling the linear model and the lens is a step further in accounting for the latter’s view of iterative learning and knowledge creation, while preserving the former’s relevance as a communication device for multiple stakeholders involving in the process.
Enactivism Meets Mechanism: Tensions & Congruities in Cognitive Science
Authors: Lee Jonny 
Published: January 2023

AbstractEnactivism advances an understanding of cognition rooted in the dynamic interaction between an embodied agent and their environment, whilst new mechanism suggests that cognition is explained by uncovering the organised components underlying cognitive capacities. On the face of it, the mechanistic model’s emphasis on localisable and decomposable mechanisms, often neural in nature, runs contrary to the enactivist ethos. Despite appearances, this paper argues that mechanistic explanations of cognition, being neither narrow nor reductive, and compatible with plausible iterations of ideas like emergence and downward causation, are congruent with enactivism. Attention to enactivist ideas, moreover, may serve as a heuristic for mechanistic investigations of cognition. Nevertheless, I show how enactivism and approaches that prioritise mechanistic modelling may diverge in starting assumptions about the nature of cognitive phenomena, such as where the constitutive boundaries of cognition lie.