bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food consumption and nutrient intake of Finnish preschool children according to parental educational level
Authors: Skaffari Essi , Vepsäläinen Henna , Nissinen Kaija , Lehto Elviira , Lehto Reetta , Roos Eva , Erkkola Maijaliisa , Korkalo Liisa 
Published: July 2023

AbstractWe examined the association between parental educational level (PEL) and children’s food consumption and nutrient intake in a sample of Finnish 3- to 6-year-old preschoolers (n 811). The data were obtained from the cross-sectional DAGIS project, conducted in eight municipalities in Finland during 2015–2016. The food consumption and nutrient intake were assessed using food records. The highest educational level of the family was used as the indicator of socio-economic status. Differences in diet by PEL were analysed using a hierarchical linear model adjusted for energy intake. Compared with high PEL, low PEL was associated with a child’s lower consumption of fresh vegetables and salads, vegetarian dishes, berries, white bread, blended spread, skimmed milk and ice cream but higher consumption of milk with 1–1·5 % fat content, dairy-based desserts and sugar-sweetened soft drinks. Food consumption was also examined after disaggregating dishes into their ingredients. Low PEL was associated with lower consumption of vegetables, nuts and seeds, berries and fish but higher consumption of red meat. Children in the low PEL, compared with the high PEL group, had a lower intake of protein, fibre, EPA, DHA, vitamin D, riboflavin, vitamin B6, folate, vitamin B12, vitamin C, potassium, phosphorous, Ca, Mg, Zn and iodine but a higher intake of fat and saturated, trans and MUFA. The observed diet-related disparities highlight the need for policy actions and interventions supporting healthy eating patterns such as high consumption of vegetables, nuts and berries in childhood, paying special attention to those with low PEL.
Making MalagasyZebu: The Biopolitics of Cattle Commodification in Socialist Madagascar, 1960–1978
Authors: Rijke-Epstein Tasha 
Published: July 2023

AbstractAt the dawn of Madagascar’s independence in 1960, political entrepreneurs harnessed the enduring significance of Malagasy cattle, known aszebu, and declared them integral to the new national identity. From 1960–1972, President Philibert Tsiranana led the country through the period known as the First Republic, in which officials and technocrats launched development projects around breeding and constructing abattoirs and feedlots, in the hopes of creating a viable international meat export economy. For elites,zebuserved as speculative vessels for remaking economic and political geographies and shifting away from dependence on French interests. Malagasy government officials and technical experts saw pastoralists as key to actualizing the economic potential of cattle and they sought to combat “peasant idleness” as a hindrance to Madagascar’s flourishing. Pastoralists, though, challenged the bounds of top-down authority and debated the kinds of knowledge that could and should inform modernization projects in the new nation-state. Cattle ranchers’ critiques of the logics and encroachment of prescriptive modernization schemes during the 1960s and 1970s can be understood as their insistence on sharing in the fruits of independence, and that they, with their deep knowledge of cattle behavior, had a role to play in forging meaningful, prosperous lives in broader ancestor-focused cosmologies. Investigating the twinned history of Madagascar’s beef exportation and cattle modernization plans reveals how cattle were enlisted in the project of nation-making and a crucial moment of possibility, in which state-crafters ambitiously pursued a path toward self-determination while navigating oscillating geopolitics and asymmetrical global economic relations.
Natural infection of white grubs (Coleoptera: Scarabaeidae) with entomopathogenic nematodes in the KwaZulu-Natal province of South Africa
Authors: Katumanyane A. , Slippers B. , Wondafrash M. , Malan A. P. , Hurley B. P. 
Published: July 2023

AbstractWhite grubs are root feeding larvae of beetles (Coleoptera: Scarabaeidae) that are sporadic pests in agriculture and can lead to economic damage. The grubs feed on the roots of plants, while the adult beetle can bore into underground stems, as well as cause defoliation of plants. Sporadic incidence of larvae with symptoms of nematode infections were detected in wattle and sugarcane plantations in the KwaZulu-Natal province of South Africa. The larvae with infection symptoms were isolated, washed, and put on water traps to collect infective juveniles of possible nematode infections. Three species of entomopathogenic nematodes (EPNs) were isolated from the white grub larvae. These includedSteinernema bertusiisolated fromMaladerasp. 4.,Oscheius myriophilafromMaladerasp. 4 andSchizonchya affinis,andSteinernema fabiiisolated fromMaladerasp. 4.,Pegylis sommeri,andS. affinis.Of theseS. fabiiwas the most common species in the sample (87%). This is the first report of such a high diversity of locally occurring EPNs found naturally associated with white grub species in this region of South Africa.
A new species of the genusAnamylopsora(Baeomycetaceae; Ascomycota) from Deosai National Park, Gilgit-Baltistan, Pakistan
Authors: Usman Muhammad , Firdous Qudsia , Dyer Paul S. , Khalid Abdul Nasir 
Published: July 2023

AbstractA novel lichen species occurring on rocks was collected from three different localities within Deosai National Park, Gilgit-Baltistan, Pakistan. Phylogenetic analyses of the nrDNA ITS and nuLSU regions revealed that it clustered within the genusAnamylopsora. Further chemical and morpho-anatomical analyses confirmed its uniqueness, and it is described here as a new species under the nameA. pakistanica. The distinguishing characters are: an irregularly squamulose appressed thallus on rocks without rhizines; an epinecral layer up to 25 μm thick; ascospores that are hyaline, simple, thick-walled with a smooth surface; septate paraphyses with a pigmented apical cell in a gel-like matrix; globose to subglobose pycnidia with hyaline and bacilliform pycnidiospores. In particular, the species is distinguished from other members of the genus by morpho-anatomical features including the coloration of the thalli, the presence of a thick lower cortex (up to 100 μm), and the presence of simple, thick-walled ascospores. Specimens were found at altitudes up to 4587 m, the highest elevation yet reported forAnamylopsora. A key and comparison to all existing species of the genusAnamylopsorais also given.
Changes in spinescence across leaf ontogeny support the optimal defence hypothesis in blackberries (Rubus adenotrichos)
Authors: Farji-Brener Alejandro , Díaz Débora Elías , Holanda Isabelle , Ricaurte Andrés Sierra , Barrantes Kenneth , Gutiérrez-Campos Pablo José 
Published: July 2023

Abstract
Hypotheses based on allocation theory and herbivore selection offer opposite predictions about how defence levels against herbivores change as the plant tissue grows. The growth differentiation balance hypothesis (GDBH) assumes that defences will be resource-limited in immature tissues and predict that defence levels increase as the plant tissue grows. Conversely, the optimal defence hypothesis (ODH) proposes that plants would have the highest level of defences in the parts that have the highest value in terms of fitness and/or are more frequently attacked by herbivores, such as young tissues. We examine whether spinescence in the shrub Rubus adenotrichos (blackberry) change as the leaf grows, and if this change is consistent with the GDBH or the ODH. We compare the petiole area occupied by prickles, the prickles density and the individual prickle area in mature versus young petioles from Rubus adenotrichos. Our results show that, in R. adenotrichos, young tissues are more protected than mature tissues. Prickles density and the petiole area occupied by prickles were up to 25% higher in young petioles than in mature ones. These results support the ODH, reinforcing the idea that extrinsic factors such as herbivores pressure might drive the change of structural defences level across leaf ontogeny.
Twenty-month-olds categorically discriminate similar sounding vowels regardless of vocabulary level, an event related potentials (ERP) study
Authors: CHEN Ao 
Published: July 2023

AbstractThe current study investigated whether vocabulary relates to phonetic categorization at neural level in early childhood. Electoencephalogram (EEG) responses were collected from 53 Dutch 20-month-old children in a passive oddball paradigm, in which they were presented with two nonwords “giep” [ɣip] and “gip” [ɣɪp] that were contrasted solely by the vowel. In the multiple-speaker condition, both nonwords were produced by twelve different speakers; while, in the single-speaker condition, one single token of each word was used as stimuli. Infant positive mismatch responses (p-MMR) were elicited in both conditions without significant amplitude differences. When the infants were median split based on vocabulary level, the large and small vocabulary groups showed comparable p-MMR amplitudes yet different scalp distribution in both conditions. These results suggest successful phonetic categorization of native similar sounding vowels at 20 months, and a close relationship between speech categorization and vocabulary development.
“Mom said it in quotation marks!” Irony comprehension and metapragmatic awareness in 8-year-olds
Authors: GARFINKEL Sarah , ROWE Meredith L. , BOSACKI Sandra , BANASIK-JEMIELNIAK Natalia 
Published: July 2023

AbstractThis study investigated links between the development of children’s understanding of ironic comments and their metapragmatic knowledge. Forty-six 8-year-olds completed the short version of the Irony Comprehension Task, during which they were presented with ironic comments in three stories and asked to provide reasons for why the speaker in a story uttered an ironic comment. We coded their responses and compared the results to similar data collected previously with 5-year-olds. Results showed that compared to younger children, 8-year-olds frequently refer to interlocutors’ emotions, intentions, and to metapragmatics. These results support the view that comprehension of verbal irony is an emerging skill in children.
Community courts as legal transplants: a socio-legal case study from the Netherlands
Authors: Doornbos Nienke 
Published: July 2023

AbstractAiming to ensure a responsive and socially relevant approach to court cases, judiciaries have initiated innovative projects, such as problem-solving community courts, over the last three decades. In this socio-legal case study, I analyse the legal transplantation of a community court from the US to the Netherlands. Drawing on eighteen months of ethnographic field work (interviews, observations and file research), the study shows that, during the transplantation process, the goal of serving the neighbourhood receded into the background, while the goal of solving the problems of defendants gained even more prominence than it already had at the inception of the court. The conditions that have played a role in the path that the court has carved out to legitimise its activities differ from its American counterparts. The adjustments signify important internal legal cultural differences and illustrates how the implementation process is formed by opinions about the proper role of judges.
Introducing Diinamic, a flexible and robust method for clustering analysis in single-molecule localization microscopy
Authors: Paupiah Anne-Lise , Marques Xavier , Merlaud Zaha , Russeau Marion , Levi Sabine , Renner Marianne 
Published: July 2023

Abstract
Super-resolution microscopy allowed major improvements in our capacity to describe and explain biological organization at the nanoscale. Single-molecule localization microscopy (SMLM) uses the positions of molecules to create super-resolved images, but it can also provide new insights into the organization of molecules through appropriate pointillistic analyses that fully exploit the sparse nature of SMLM data. However, the main drawback of SMLM is the lack of analytical tools easily applicable to the diverse types of data that can arise from biological samples. Typically, a cloud of detections may be a cluster of molecules or not depending on the local density of detections, but also on the size of molecules themselves, the labeling technique, the photo-physics of the fluorophore, and the imaging conditions. We aimed to set an easy-to-use clustering analysis protocol adaptable to different types of data. Here, we introduce Diinamic, which combines different density-based analyses and optional thresholding to facilitate the detection of clusters. On simulated or real SMLM data, Diinamic correctly identified clusters of different sizes and densities, being performant even in noisy datasets with multiple detections per fluorophore. It also detected subdomains (“nanodomains”) in clusters with non-homogeneous distribution of detections.
Changing Sub‐Surface Chemistry Resulting From a 26‐Million‐Year Unconformity: Porewater Chemistry From IODP Site U1553 in the South Pacific
Authors: Reis A. J. , Fichtner V. , Erhardt A. M. 
Published: July 2023

AbstractWhereas changes in pore water chemistry are known to impact carbonate sediment geochemistry, little is known about the impact of long unconformities on carbonate alteration. IODP Site 378‐U1553 on the southern Campbell Plateau, with a 26‐million‐year, erosional unconformity, provides a key location for examining the impact of long‐term unconformities on sub‐surface chemistry and carbonate archives. This study examined 76 interstitial water samples for sulfate sulfur and oxygen isotopes, as well as 28 bulk carbonate samples for carbonate associated sulfate (CAS) sulfur isotopes, to quantify the effects of this unconformity on the sub‐surface redox chemistry of the Site. The current state of the system suggests limited influence of redox processes on the CAS archive. Manganese reduction reaches 30 mbsf, with a decrease in manganese reduction between 20 and 30 mbsf. Below 30 mbsf, the system transitions to iron reduction to a depth of approximately 140 mbsf where sulfate reduction begins. Dissolved sulfate sulfur and oxygen isotope values suggest repeated oxygenation of sulfides. The CAS record from the Site deviates from previously published seawater values. However, the lack of a relationship between the dissolved sulfate and CAS records suggests most of the alteration of the CAS record likely occurred before the unconformity when the carbonate sediments were more reactive. This further supports the CAS record as a relatively robust archive, withstanding most post‐depositional mechanisms of carbonate alteration.
PARP inhibitors: enhancing efficacy through rational combinations
Authors: Bhamidipati Deepak , Haro-Silerio Jaime I. , Yap Timothy A. , Ngoi Natalie 
Published: July 2023

AbstractPoly (ADP-ribose) polymerase inhibitors (PARPi) have significantly changed the treatment landscape for tumours harbouring defects in genes involved in homologous repair (HR) such as BRCA1 and BRCA2. Despite initial responsiveness to PARPi, tumours eventually develop resistance through a variety of mechanisms. Rational combination strategies involving PARPi have been explored and are in various stages of clinical development. PARPi combinations have the potential to enhance efficacy through synergistic activity, and also potentially sensitise innately PARPi-resistant tumours to PARPi. Initial combinations involving PARPi with chemotherapy were hindered by significant overlapping haematologic toxicity, but newer combinations with fewer toxicities and more targeted approaches are undergoing evaluation. In this review, we discuss the mechanisms of PARPi resistance and review the rationale and clinical evidence for various PARPi combinations including combinations with chemotherapy, immunotherapy, and targeted therapies. We also highlight emerging PARPi combinations with promising preclinical evidence.
In-situ artificial retina with all-in-one reconfigurable photomemristor networks
Authors: Cai Yichen , Jiang Yizhou , Sheng Chenxu , Wu Zhiyong , Chen Luqiu , Tian Bobo , Duan Chungang , Xiong Shisheng , Zhan Yiqiang , Cong Chunxiao , Qiu Zhi-Jun , Qin Yajie , Liu Ran , Hu Laigui 
Published: July 2023

AbstractDespite that in-sensor processing has been proposed to remove the latency and energy consumption during the inevitable data transfer between spatial-separated sensors, memories and processors in traditional computer vision, its hardware implementation for artificial neural networks (ANNs) with all-in-one device arrays remains a challenge, especially for organic-based ANNs. With the advantages of biocompatibility, low cost, easy fabrication and flexibility, here we implement a self-powered in-sensor ANN using molecular ferroelectric (MF)-based photomemristor arrays. Tunable ferroelectric depolarization was intentionally introduced into the ANN, which enables reconfigurable conductance and photoresponse. Treating photoresponsivity as synaptic weight, the MF-based in-sensor ANN can operate analog convolutional computation, and successfully conduct perception and recognition of white-light letter images in experiments, with low processing energy consumption. Handwritten Chinese digits are also recognized and regressed by a large-scale array, demonstrating its scalability and potential for low-power processing and the applications in MF-based in-situ artificial retina.
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease
Authors: Siddiqui Tohid , Cosacak Mehmet Ilyas , Popova Stanislava , Bhattarai Prabesh , Yilmaz Elanur , Lee Annie J. , Min Yuhao , Wang Xue , Allen Mariet , İş Özkan , Atasavum Zeynep Tansu , Rodriguez-Muela Natalia , Vardarajan Badri N. , Flaherty Delaney , Teich Andrew F. , Santa-Maria Ismael , Freudenberg Uwe , Werner Carsten , Tosto Giuseppe , Mayeux Richard , Ertekin-Taner Nilüfer , Kizil Caghan 
Published: July 2023

AbstractNeurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology. However, the molecular mechanisms promoting pro-neurogenic astroglial fate despite AD pathology are unknown. In this study, we used APP/PS1dE9 mouse model and induced Nerve growth factor receptor (Ngfr) expression in the hippocampus. Ngfr, which promotes neurogenic fate of astroglia during the amyloid pathology-induced neuroregeneration in zebrafish brain, stimulated proliferative and neurogenic outcomes. Histological analyses of the changes in proliferation and neurogenesis, single-cell transcriptomics, spatial proteomics, and functional knockdown studies showed that the induced expression of Ngfr reduced the reactive astrocyte marker Lipocalin-2 (Lcn2), which we found was sufficient to reduce neurogenesis in astroglia. Anti-neurogenic effects of Lcn2 was mediated by Slc22a17, blockage of which recapitulated the pro-neurogenicity by Ngfr. Long-term Ngfr expression reduced amyloid plaques and Tau phosphorylation. Postmortem human AD hippocampi and 3D human astroglial cultures showed elevated LCN2 levels correlate with reactive gliosis and reduced neurogenesis. Comparing transcriptional changes in mouse, zebrafish, and human AD brains for cell intrinsic differential gene expression and weighted gene co-expression networks revealed common altered downstream effectors of NGFR signaling, such as PFKP, which can enhance proliferation and neurogenesis in vitro when blocked. Our study suggests that the reactive non-neurogenic astroglia in AD can be coaxed to a pro-neurogenic fate and AD pathology can be alleviated with Ngfr. We suggest that enhancing pro-neurogenic astroglial fate may have therapeutic ramifications in AD.
Whole-body cellular mapping in mouse using standard IgG antibodies
Authors: Mai Hongcheng , Luo Jie , Hoeher Luciano , Al-Maskari Rami , Horvath Izabela , Chen Ying , Kofler Florian , Piraud Marie , Paetzold Johannes C. , Modamio Jennifer , Todorov Mihail , Elsner Markus , Hellal Farida , Ertürk Ali 
Published: July 2023

AbstractWhole-body imaging techniques play a vital role in exploring the interplay of physiological systems in maintaining health and driving disease. We introduce wildDISCO, a new approach for whole-body immunolabeling, optical clearing and imaging in mice, circumventing the need for transgenic reporter animals or nanobody labeling and so overcoming existing technical limitations. We identified heptakis(2,6-di-O-methyl)-β-cyclodextrin as a potent enhancer of cholesterol extraction and membrane permeabilization, enabling deep, homogeneous penetration of standard antibodies without aggregation. WildDISCO facilitates imaging of peripheral nervous systems, lymphatic vessels and immune cells in whole mice at cellular resolution by labeling diverse endogenous proteins. Additionally, we examined rare proliferating cells and the effects of biological perturbations, as demonstrated in germ-free mice. We applied wildDISCO to map tertiary lymphoid structures in the context of breast cancer, considering both primary tumor and metastases throughout the mouse body. An atlas of high-resolution images showcasing mouse nervous, lymphatic and vascular systems is accessible at http://discotechnologies.org/wildDISCO/atlas/index.php.
Heat-related mortality in Europe during the summer of 2022
Authors: Ballester Joan , Quijal-Zamorano Marcos , Méndez Turrubiates Raúl Fernando , Pegenaute Ferran , Herrmann François R. , Robine Jean Marie , Basagaña Xavier , Tonne Cathryn , Antó Josep M. , Achebak Hicham 
Published: July 2023

AbstractOver 70,000 excess deaths occurred in Europe during the summer of 2003. The resulting societal awareness led to the design and implementation of adaptation strategies to protect at-risk populations. We aimed to quantify heat-related mortality burden during the summer of 2022, the hottest season on record in Europe. We analyzed the Eurostat mortality database, which includes 45,184,044 counts of death from 823 contiguous regions in 35 European countries, representing the whole population of over 543 million people. We estimated 61,672 (95% confidence interval (CI) = 37,643–86,807) heat-related deaths in Europe between 30 May and 4 September 2022. Italy (18,010 deaths; 95% CI = 13,793–22,225), Spain (11,324; 95% CI = 7,908–14,880) and Germany (8,173; 95% CI = 5,374–11,018) had the highest summer heat-related mortality numbers, while Italy (295 deaths per million, 95% CI = 226–364), Greece (280, 95% CI = 201–355), Spain (237, 95% CI = 166–312) and Portugal (211, 95% CI = 162–255) had the highest heat-related mortality rates. Relative to population, we estimated 56% more heat-related deaths in women than men, with higher rates in men aged 0–64 (+41%) and 65–79 (+14%) years, and in women aged 80+ years (+27%). Our results call for a reevaluation and strengthening of existing heat surveillance platforms, prevention plans and long-term adaptation strategies.