bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis and sequelae of meth(acrylate) sensitization in beauticians and consumers of manicure materials
Authors: Gatica‐Ortega María E. , Rodríguez‐Lago Laura , Beneyto Pedro , Pastor‐Nieto María A. , Borrego Leopoldo 
Published: September 2023

AbstractBackgroundAllergic contact dermatitis from (meth)acrylic monomers (ACDMA) in manicure products is increasing.ObjectiveTo evaluate the prognosis, work performance impairment and sequelae of a cohort of beauticians and manicure consumers with ACDMA sensitized from the exposure to manicure products.MethodsWe conducted a telephone survey with patients diagnosed with ACDMA.ResultsOne hundred and six patients were evaluated, including 75 (70.8%) beauticians and 31 (29.2%) consumers. All were women with a mean age of 39 (19–62). Thirty‐seven of 75 beauticians (49.3%) continued to work. Twenty‐seven of 106 (25.5%) patients continued to use manicure products with (meth)acrylates regularly. Seventeen of 51 (33.3%) patients who discontinued the exposure described ongoing nail/periungual changes. Nine of 58 (15.5%) patients who required dental restoration, orthodontic or occlusal splint materials recalled reactions from them; and, 25 of 96 (26%) who used sanitary napkins recalled intolerance to them starting after the diagnosis of ACDMA. Fifteen of 25 (60%) discontinued the use of sanitary napkins.Conclusion49.3% beauticians continued to work; most patients stopped wearing acrylic manicure materials; reactions from dental materials were not uncommon, however, removal of dental materials was never required; and, reactions to sanitary napkins developing after the diagnosis of ACDMA were common most leading to discontinuation of use.
Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases
Authors: Bakhshwin Ahmed , Oaxaca Gabriel , Armstrong Susan , Ko Jennifer , Billings Steven 
Published: September 2023

AbstractBackgroundDesmoplastic fibroblastoma (collagenous fibroma) is a rare soft tissue tumor that usually arises in the subcutis or skeletal muscle. Cases superficial to fascia are unusual and can cause diagnostic difficulty. We present 11 cases of superficial desmoplastic fibroblastoma involving a wide anatomic distribution.MethodsArchives were searched using the term “desmoplastic fibroblastoma” over a 10‐year period (2012–2022). Cases superficial to fascia were retrieved, and available clinicopathologic features were recorded. Only cases involving the dermis were included.ResultsEleven cases were identified, all of which were received in consultation. Tumors involved the head and neck (2), lower extremity (2), back (2), foot (1), shoulder (1), axilla (1), hand (1), and breast (1). Each consisted of a hypocellular proliferation of bland stellate to spindled fibroblasts set in a collagenous to focally myxoid stroma. The immunohistochemical stains available for review demonstrated SMA positivity (4/7) and negative immunoreactivity for CD34 (0/6), EMA (0/3), desmin (0/3), and S100 (0/7).ConclusionsDesmoplastic fibroblastoma may present superficially in the dermis to subcutis, posing a potential source of diagnostic difficulty. Recognition of the characteristic histopathologic features of desmoplastic fibroblastoma with judicial use of immunohistochemical stains should allow for accurate diagnosis.
CD30+ lymphoproliferative disorder masquerading as an atypical melanocytic proliferation
Authors: Hernandez‐Rovira Miguel A. , Lama Carine M. , Musiek Amy C. M. , Russell Aaron J. 
Published: September 2023

AbstractHeuristics are cognitive strategies used to facilitate decision‐making. They can be helpful tools for expediting pathologic diagnoses, however, they can also affect judgment and lead to biases that guide the pathologist astray. We report the case of a 52‐year‐old female who presented with two unusual pigmented lesions on the wrist and thigh that clinically and histopathologically resembled an atypical melanocytic proliferation. A biopsy of the thigh revealed a broad proliferation of large, atypical cells forming nests within a heavily pigmented epidermis. The lesion was initially misdiagnosed as melanoma in situ, despite equivocal staining for melanocytic markers, likely due to anchoring and adjustment as well as availability biases, which restricted the differential diagnosis and limited the selection of immunohistochemical stains. It was later discovered through chart review that the patient had a prior history of a cutaneous CD30+ lymphoproliferative disorder, which eventually led to the appropriate diagnosis in this case. Herein, we highlight a rare and unusual presentation of a pigmented epidermotropic CD30+ lymphoproliferative disorder, along with the biases leading to its misdiagnosis and the steps leading to the revelation of the actual diagnosis.
Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes
Authors: Rückert Ann‐Kathrin , Ast Julia , Hasib Annie , Nasteska Daniela , Viloria Katrina , Broichhagen Johannes , Hodson David J. 
Published: September 2023

AbstractWe previously developed, synthesized and tested light‐activated sulfonylureas for optical control of KATP channels and pancreatic beta cell activity in vitro and in vivo. Such technology relies on installation of azobenzene photoswitches onto the sulfonylurea backbone, affording light‐dependent isomerization, alteration in ligand affinity for SUR1 and hence KATP channel conductance. Inspired by molecular dynamics simulations and to further improve photoswitching characteristics, we set out to develop a novel push‐pull closed ring azobenzene unit, before installing this on the sulfonylurea glimepiride as a small molecule recipient. Three fine‐tuned, light‐activated sulfonylureas were synthesized, encompassing azetidine, pyrrolidine and piperidine closed rings. Azetidine‐, pyrrolidine‐ and piperidine‐based sulfonylureas all increased beta cell Ca2+‐spiking activity upon continuous blue light illumination, similarly to first generation JB253. Notably, the pyrrolidine‐based sulfonylurea showed superior switch OFF performance to JB253. As such, third generation sulfonylureas afford more precise optical control over primary pancreatic beta cells, and showcase the potential of pyrrolidine‐azobenzenes as chemical photoswitches across drug classes.
Younger patients and low c‐peptide immunoreactivity index but not nutritional states affect fasting blood ketone levels in Japanese with type 1 diabetes after sodium‐glucose cotransporter 2 inhibitor administration
Authors: Nakajima Hanako , Okada Hiroshi , Yoshimura Yuta , Tanaka Toru , Hasegawa Goji , Mitsuhashi Kazuteru , Kitagawa Noriyuki , Okamura Takuro , Hashimoto Yoshitaka , Senmaru Takafumi , Ushigome Emi , Nakanishi Naoko , Yamazaki Masahiro , Hamaguchi Masahide , Fukui Michiaki 
Published: September 2023

AbstractAimSodium‐glucose cotransporter 2 inhibitors (SGLT2is) are available for individuals with type 1 diabetes, but appropriate use is recommended to prevent ketosis or ketoacidosis. This study aimed to evaluate the risk of ketosis in people with type 1 diabetes, focusing on the relationship between nutritional assessment, glycaemic status, c‐peptide immunoreactivity (CPR) index and body composition.Materials and MethodsIn total, 46 Japanese patients with type 1 diabetes were included, and dietary assessment from food photographs and ketone levels were evaluated before and after taking SGLT2is. The effect of diet on morning ketone levels was also investigated.ResultsAll patients had an increase in mean ketone concentrations after taking SGLT2is (before 0.12 ± 0.06 mmol/L, after 0.23 ± 0.16 mmol/L). A significant negative correlation was found between average morning ketone levels and age (r = −0.514, p < .001) and the CPR index (r = −0.523, p = .038) after taking SGLT2is. Using a mixed‐effects model based on the results before starting the inhibitors, it was noted that both patient‐to‐patient and age, or patient‐to‐patient and capacity of insulin secretion, influenced the ketone levels. Multiple regression analysis showed that factors associated with the risk of increasing ketone levels after taking SGLT2is were younger age (β = −0.504, p = .003) and a low ratio of basal to bolus insulin (β = −0.420, p = .005).ConclusionsWhen administering SGLT2is to patients with a low CPR index or younger patients with type 1 diabetes, adequate instructions to prevent ketosis should be given.
Phrase parsing in a second language as indexed by the closure positive shift: The impact of language experience and acoustic cue salience
Authors: Gilbert Annie C. , Lee Jasmine G. , Wolpert Max , Baum Shari R. 
Published: September 2023

AbstractDespite the importance of prosodic processing in utterance parsing, a majority of studies investigating boundary localization in a second language focus on word segmentation. The goal of the present study was to investigate the parsing of phrase boundaries in first and second languages from different prosodic typologies (stress‐timed vs. syllable‐timed). Fifty English‐French bilingual adults who varied in native language (French or English) and second language proficiency listened to English and French utterances with different prosodic structures while event‐related brain potentials were recorded. The utterances were built around target words presented either in phrase‐final position (bearing phrase‐final lengthening) or in penultimate position. Each participant listened to both English and French stimuli, providing data in their native language (used as reference) and their second language. Target words in phrase‐final position elicited closure positive shifts across listeners in both languages, regardless of the language‐specific acoustic cues associated with phrase‐final lengthening (shorter phrase‐final lengthening in English compared to French). Interestingly, directional effects were observed, where learning to parse English as a second language in a native‐like manner seemed to require a higher proficiency level than learning to parse French as a second language. This pattern of results supports the idea that L2 listeners need to learn to recognize L2‐specific phrase‐final lengthening regardless of the apparent similarity across languages and that some language combinations might present greater challenges than others.
A large‐scale decision‐making model for the expediency of funding the development of tourism infrastructure in regions
Authors: Skare Marinko , Gavurova Beata , Polishchuk Volodymyr 
Published: September 2023

AbstractThe main goal of this study was to develop a hybrid decision‐making support model regarding the feasibility of financing the development of tourism infrastructure of regions for V4 countries, based on the predicted assessment of the level of tourist movement in relation to the infrastructure and accessibility of the studied regions, expert opinions regarding the level of quality of tourist services and tourism development, as well as opinions of experts regarding the prospects of rapid growth of tourist movement in the region. For the first time, a hybrid fuzzy model for assessing the level of tourism quality in the region was developed, using the opinions of experts regarding the level of quality of tourist services and tourism development. For the first time, a five‐layer neuro‐fuzzy model was developed to derive a quantitative and linguistic assessment of the level of feasibility of financing the development of tourist infrastructure based on the experience, knowledge, and competences of experts regarding the prospects of rapid growth of tourist movement in the studied region. The research results were tested, and the developed model was verified on real data for 43 regions of the V4 countries.
Evaluation of the influence of mean stress on the fatigue behavior of notched and smooth medium carbon steel components through an energetic local approach
Authors: Milone Aldo , Foti Pietro , Filippi Stefano , Landolfo Raffaele , Berto Filippo 
Published: September 2023

AbstractIn the present paper, the influence of the mean stress on the fatigue behavior of smooth and notched medium carbon steel components (C45 grade) is investigated through conventional and more advanced design methodologies. Original experimental data are provided for two notched specimen geometries and three different high load ratios (R = {0.7, 0.8, 0.9}). To assess the effect of the mean stress in a larger range, the bulk of fatigue data has been widened through more than 150 tests on C45 steel drawn from literature. The considered experimental data ranged between a load ratio of −2 and 0.9. The mean stress effect has been assessed in a first attempt through well‐established literature models resulting in a data correlation characterized by a large scatter. Finally, an attempt to uniquely consider both geometrical and load ratio effects has been performed through a numerical application of the strain energy density (SED) method. Elevated load ratios (R ≥ 0.7) prove to be highly detrimental for C45 steel with a fatigue life reduction of up to 3 orders of magnitude; however, this effect can be considered with a sufficient degree of accuracy through the SED method.
Prognostic value of virtual portal pressure gradient response in compensated cirrhotic patients treated with carvedilol
Authors: Zhang Shuo , Cai Li , Zhong Hui , Yang Bo , Song Weiping , Jia Haoyu , Chen Shuai , Zhu Fengshang , Li Jing , Yang Changqing 
Published: September 2023

AbstractAimThis study aimed to assess the prognostic significance of virtual portal pressure gradient (vPPG) response to carvedilol in patients with compensated cirrhosis (CC).MethodsCompensated cirrhosis patients with high‐risk varices were prospectively enrolled to receive carvedilol for prevention of first variceal hemorrhage (VH) and followed up for 1 year. The vPPG response was defined as a reduction of vPPG >10% from baseline after 1‐month therapy. Logistic and Cox regression analyses were performed to identify independent predictors for vPPG response and first decompensation, respectively. Competitive risk models were constructed to predict disease progression, and validated using the C‐index, Kaplan–Meier analysis, competitive risk analysis, and calibration curves.ResultsA total of 129 patients completed this study, of whom 56 (43.4%) achieved vPPG response and were referred as vPPG responders. Baseline vPPG, red color sign, Model for End‐stage Liver Disease score, serum monocyte chemoattractant protein‐1 (MCP‐1), and laminin levels significantly correlated with vPPG response, which itself was further documented as an independent predictor of VH, ascites, and overall decompensation events in CC. Moreover, the red color sign or Child–Turcotte–Pugh score effectively predicted VH, while ascites correlated well with portal flow velocity or MCP‐1. The predictive models for VH and ascites showed a good discrimination with C‐index values of 0.747 and 0.689 respectively, and the high consistency on calibration curves.ConclusionThe vPPG response could be used as a noninvasive tool for prediction of disease progression in patients with CC.
Genetic parameters for carcass and meat quality traits in Jinhua, Duroc, and their crossbred pigs
Authors: Terada Kei , Ohtani Toshiyuki , Ogawa Shinichiro , Hirooka Hiroyuki 
Published: September 2023

AbstractJinhua pigs have excellent meat quality and intramuscular fat content (IMF). Crossbreeding of Jinhua with Duroc pigs with high productivity was conducted to develop a new composite breed that possesses the beneficial characteristics of both breeds. The objective of this study was to estimate the crossbreeding parameters (additive breed, dominance, and epistatic loss effects) using the Kinghorn model and genetic parameters (heritability and genetic correlation) for carcass and meat quality traits by analysing the phenotypic data of Jinhua, Duroc, and their crossbred pigs. Backfat thickness at the thinnest point above the 9th to 13th thoracic vertebrae (BF), longissimus muscle area between the 4th and 5th thoracic vertebrae (LMA), meat shear force value (SFV), and IMF were measured. The additive breed effects were significant for all traits: 1.59 cm, −8.30 cm2, −6.38 lb/cm2, and 1.76% for BF, LMA, SFV, and IMF, respectively. The dominance effect was significant for LMA (7.41 cm2) and IMF (−2.46%), whereas the epistatic loss effect was significant for only LMA (−15.18 cm2). The estimated heritability values were high, ranging from 0.58 for IMF to 0.76 for LMA. A negative but non‐significant genetic correlation of −0.11 was estimated between BF and IMF; however, previous studies have reported that the genetic correlation between these traits is moderately positive in modern western pigs. Our results imply that, with the estimation of crossbreeding and genetic parameters, genetic improvement could be implemented to produce a new composite breed with good meat quality and productivity, to meet Japanese market requirements, by crossbreeding Jinhua and Duroc pigs.
Efficacy and safety of olmesartan medoxomil‐amlodipine besylate tablet in Chinese patients with essential hypertension: A prospective, single‐arm, multi‐center, real‐world study
Authors: Cui Zhaoqiang , Qiu Zhaohui , Cheng Wenli , Hu Wei , Ma Genshan , Cai Xiaojun , Jin Yafei , Zhao Yi , He Liqun , Li Ying , Bu Peili , Chen Xiaoping , Wang Ruxing , Chen Lin , Dong Peng , Feng Liuliu , Han Xuebin , Hong Mei , Hou Yinglong , Liao Minlei , Wang Mingliang , Wang Xiaoyan , Xie Jianhong , Xu Yawei , Wang Zhenxing , Huang Kai , Li Yongle , Li Dongsheng , Ji Xiaojun , Huang Jing , Wang Jun , Fang Danhong , Wang Jian'an , Tang Lijiang , Liu Yingwu , Fu Guosheng , Du Juan , Wang Ling , Liu Mengqi , Ge Junbo 
Published: September 2023

AbstractThere lacks real‐world study with a large sample size assessing olmesartan medoxomil‐amlodipine besylate (OM‐AML) tablet. Therefore, this study aimed to evaluate the efficacy and safety of OM‐AML tablet in patients with essential hypertension. Totally, 1341 patients from 36 medical centers with essential hypertension who took OM‐AML (20/5 mg) tablet were analyzed in the current prospective, single‐arm, multi‐center, real‐world study (SVK study). Seated systolic blood pressure (SeSBP) and seated diastolic blood pressure (SeDBP) at baseline, week (W)4 and W8 were measured. The mean (±SE) change of SeSBP/SeDBP was ‐10.8 ± 0.4/‐6.6 ± 0.3 mmHg at W4 and ‐12.7 ± 0.5/‐7.6 ± 0.3 mmHg at W8, respectively. At W4, 78.8% and 29.0% patients achieved BP target by China and American Heart Association (AHA) criteria; at W8, 84.7% and 36.5% patients reached blood pressure (BP) target by China and AHA criteria, accordingly. Meanwhile, 80.2% and 86.4% patients achieved BP response at W4 and W8, respectively. Home‐measured SeSBP and SeDBP decreased from W1 to W8 (bothp < .001). Besides, patients’ and physicians’ satisfaction were elevated at W8 compared with W0 (bothp < .001). The medication possession rate was 94.8% from baseline to W4 and 91.3% from baseline to W8. The most common drug‐related adverse events were nervous system disorders (4.6%), vascular disorders (2.6%), and general disorders and administration site conditions (2.3%) by system organ class, which were generally mild and manageable. In conclusion, OM‐AML tablet is one of the best antihypertensive agents in patients with essential hypertension.
The role of regulatory T cells in the pathogenesis of acute kidney injury
Authors: Liu Xiaoyou , Hu Jianmin , Liao Guorong , Liu Ding , Zhou Song , Zhang Jie , Liao Jun , Guo Zefeng , Li Yuzhu , Yang Siqiang , Li Shichao , Chen Hua , Guo Ying , Li Min , Fan Lipei , Li Liuyang , Zhao Ming , Liu Yongguang 
Published: September 2023

AbstractThe incidence of acute kidney injury (AKI) is on the rise and is associated with high mortality; however, there are currently few effective treatments. Moreover, the relationship between Tregs and other components of the immune microenvironment (IME) in the pathogenesis of AKI remains unclear. We downloaded four publicly accessible AKI datasets, GSE61739, GSE67401, GSE19130, GSE81741, GSE19288 and GSE106993 from the gene expression omnibus (GEO) database. Additionally, we gathered two kidney single‐cell sequencing (scRNA‐seq) samples from the Department of Organ Transplantation at Zhujiang Hospital of Southern Medical University to investigate chronic kidney transplant rejection (CKTR). Moreover, we also collected three samples of normal kidney tissue from GSE131685. By analysing the differences in immune cells between the AKI and Non‐AKI groups, we discovered that the Non‐AKI group contained a significantly greater number of Tregs than the AKI group. Additionally, the activation of signalling pathways, such as inflammatory molecules secretion, immune response, glycolytic metabolism, NOTCH, FGF, NF‐κB and TLR4, was significantly greater in the AKI group than in the Non‐AKI group. Additionally, analysis of single‐cell sequencing data revealed that Tregs in patients with chronic kidney rejection and in normal kidney tissue have distinct biology, including immune activation, cytokine production, and activation fractions of signalling pathways such as NOTCH and TLR4. In this study, we found significant differences in the IME between AKI and Non‐AKI, including differences in Tregs cells and activation levels of biologically significant signalling pathways. Tregs were associated with lower activity of signalling pathways such as inflammatory response, inflammatory molecule secretion, immune activation, glycolysis.
Timing of orthostatic hypotension and its relationship with falls in older adults
Authors: Petriceks Aldis H. , Appel Lawrence J. , Miller Edgar R. , Mitchell Christine M. , Schrack Jennifer A. , Mukamal Kenneth J. , Lipsitz Lewis A. , Wanigatunga Amal A. , Plante Timothy B. , Michos Erin D. , Juraschek Stephen P. 
Published: September 2023

AbstractBackgroundThere is inconsistent evidence on the optimal time after standing to assess for orthostatic hypotension. We determined the prevalence of orthostatic hypotension at different time points after standing in a population of older adults, as well as fall risk and symptoms associated with orthostatic hypotension.MethodsWe performed a secondary analysis of the Study to Understand Fall Reduction and Vitamin D in You (STURDY), a randomized clinical trial funded by the National Institute on Aging, testing the effect of differing vitamin D3 doses on fall risk in older adults. STURDY occurred between July 2015 and May 2019. Secondary analysis occurred in 2022. Participants were community‐dwelling adults, 70 years or older. In the orthostatic hypotension assessment, participants stood upright from supine position and underwent six standing blood pressure measurements (M1–M6) in two clusters of three measurements (immediately and 3 min after standing). Cox proportional hazard models were used to examine the relationship between orthostatic hypotension at each measurement and subsequent falls. Participants were followed until the earlier of their 24‐month visit or study completion.ResultsOrthostatic hypotension occurred in 32% of assessments at M1, and only 16% at M5 and M6. Orthostatic hypotension from average immediate (M1‐3) and average delayed (M4‐6) measurements, respectively, predicted higher fall risk (M1‐3 = 1.65 [1.08, 2.52]; M4‐6 = 1.73 [1.03, 2.91]) (hazard ratio [95% confidence interval]). However, among individual measurements, only orthostatic hypotension at M5 (1.84 [1.16, 2.93]) and M6 (1.85 [1.17, 2.91]) predicted higher fall risk. Participants with orthostatic hypotension at M1 (3.07 [1.48, 6.38]) and M2 (3.72 [1.72, 8.03]) were more likely to have reported orthostatic symptoms.ConclusionsOrthostatic hypotension was most prevalent and symptomatic immediately within 1–2 min after standing, but more informative for fall risk after 4.5 min. Clinicians may consider both intervals when assessing for orthostatic hypotension.