bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objek Wisata Pemandian Alam Bektiharjo Sebagai Sumber Pembelajaran Biologi
Authors: Lestari Windhiana Ayu , Cintamulya Imas 
Published: August 2023

Background: Objek wisata Bektiharjo merupakan objek wisata alam yang memiliki potensi keanekaragaman hayati yang melimpah, kondisi lingkungan yang masih alami, dan interaksi sosial-ekonomi masyarakat yang beragam. Penelitian ini bertujuan untuk mendeskripsikan tentang pemanfaatan objek wisata Bektiharjo sebagai sumber pembelajaran melalui studi tentang kelimpahan keanekaragaman hayati, kondisi kelayakan lingkungan dan kondisi sosial-ekonomi di objek wisata Bektiharjo. Metode: Penelitian ini menggunakan dekskriptif kuantitatif. Intrumen yang digunakan dalam penelitian ini adalah lembar observasi dan angket. Lembar observasi digunakan untuk mendapatkan data kelimpahan keanekaragaman hayati dan kondisi kelayakan lingkungan objek wisata. Angket digunakan untuk mendapatkan data tentang kondisi sosial ekonomi masyarakat. Data yang terkumpul selanjutnya dianalisis secara deskriptif. Hasil: Hasil penelitian menunjukkan objek wisata Bektiharjo memiliki kelimpahan keanekaragaman hayati dalam kategori keanekaragaman tinggi, kemerataan tinggi, komunitas stabil dan dominansi jenis relative sedang, kondisi kelayakan lingkungan dikategorikan sangat baik, dan kondisi sosial ekonomi dikategorikan sangat baik. Kesimpulan: Objek wisata Bektiharjo dapat digunakan sebagai sumber pembelajaran bagi mahasiswa pendidikan biologi. Dari hasil penelitian ini diharapkan dapat menjadi alternatif pemanfaatan objek wisata sebagai sumber pembelajaran yang dapat digunakan oleh berbagai jenjang pendidikan.
Aralia armata (Wall.) Seem, a potential herb in treatment and complication recover therapy for stroke disease: A mini opinion and call for further research
Authors: Le Quang-Ung , Le Thi-Thu 
Published: August 2023

Based on our knowledge, experience and field survey in the treatment of stroke by complementary/alternative medicine and especially the herb therapy, we briefly commented on properties of curing ischemic stroke of Aralia armata (Wall.) Seem and suggest that the future research to insightfully educidate this science opinion is necessary.
Keywords: Aralia armata (Wall.), stroke disease, ischemic stroke
To investigate phytochemical parameter, Pharmacognostical evaluation, pharmacological (anti-bacterial) activity of the extract of Euphorbia pulcherrima
Authors: Basnett Anyash , Pradhan Sushilta , Das Rajat , Sharma Chandrika 
Published: August 2023

Introduction: Euphorbia pulcherrima is member of Euphorbiaceae family of medicinal plants, and it is used to cure variety of ailments which includes toothache, vomiting, fractures, severe bleeding, bruising, and hypermenorrhoea. Euphorbia pulcherrima has been found to possess a variety of chemicals, including alkaloids, steroids, terpenoids, flavonoids and reducing sugars. The review analyses its pharmacological profile, chemical component, and phytochemistry, with an emphasis on antioxidant activity, antimicrobial activity, Osteoclast activity, analgesic activity, anti-inflammatory activity, sedative activity, muscle relaxant activity, anticonvulsant activity and toxicological profile, in order to better assess the plants medicinal potential. Traditionally the latex has been employed as an anti-vomiting and toothache treatment. Aches and pains have been treated with leaf poultices. In traditional Chinese medicine it has been used it to treat fractures, severe bleeding, bruising, and hypermenorrhoea.
Methods: Due to extensive research on the pharmacological effects and active compounds of Euphorbia pulcherrima, it has a great deal of potential in modern medicine. Phyto, physicochemical standardization of dried, matured root of Euphorbia pulcherrima has been carried out in the present study. The study includes organoleptic characters along with estimation of its physicochemical parameters such as loss on drying, ash values, extractability in water and methanol. Preliminary phytochemical screening and anti-bacterial assay has been conducted.
Conclusion: As there is not enough evidence for detailed physicochemical and phytochemical evaluation on root of Euphorbia pulcherrima is reported. The present study reveals that the selected plant extract produces antimicrobial activity with dose dependent manner. However, it needs further evaluation in clinical settings before consideration for the treatment of different diseases.
Keywords: Euphorbia pulcherrima, Phytochemicals, pharmacological activity, Physicochemical.
Comparative Study on the Efficacy of Vipadika Hara Ghrita and Taila Prepared with Go Ksheera and Arka Ksheera in the Management of Vipadika Kushta: A Case Study
Authors: Surekha O. , Srikanth Babu P. , Swaroopa A. 
Published: August 2023

Objective: In Ayurveda, majority of skin diseases are dealt under broader term Kushta. As per acharya Charaka, Vipadika kushta is classified under Kshudra kushta. This can be correlated with Palmo-plantar psoriasis, which mainly effects palms and soles of a person causing cracks associated with severe pain, itching, discolouration and burning sensation. In the present study, an effort is made to compare clinical efficacy of Vipadikahara ghrita and taila prepared using go ksheera and arka ksheera in two different batches for the treatment of Vipadika kushta. Intervention: Vipadikahara ghrita & taila is a yamaka preparation that is mentioned in both charaka samhitha and ashtanga hridaya kushta chikitsa adhyaya, in the context of vipadika kushta. In this formulation ksheera is one of the ingredients, where specific type of ksheera to be used is not specified in charaka samhitha. Whereas in ashtanga hridaya commentary by Kaviraj Athrideva Gupta, usage of arka ksheera is mentioned. As specific ksheera is not mentioned in Charaka samhitha, go ksheera is taken and its effect is compared with the arka ksheera. Vipadikahara Ghrita & taila is administered externally for 15 days and changes are noted. Results: Vipadikahara ghrita & taila prepared with go ksheera helped in reducing only pain, whereas that prepared with arka ksheera reduced pain, itching, discolouration and size of the lesion. Conclusion: Hence it can be said that arka ksheera is found to be more effective in the present case study.
Keywords: Vipadika kushta, Vipadika hara ghrita & taila, Go ksheera, Arka ksheera, Palmo-plantar Psoriasis.
Cyperus rotundus commonly used drug in Unani medicine
Authors: Ahmed Reesha , Ahmed Mohammed Wasim , Khan Asma Sattar , Ahmad Anees 
Published: August 2023

Herbal medicine is the oldest form of medicine known to mankind. Cyperus rotundus L. is the world worst weed native to India, which belongs to the family Cyperaceae. It is a smooth, erect, glabrous, grass like, fibrous rooted, perennial herb that grows up to 15–60 cm height, and reproduces widely through rhizomes and tubers. Rhizomes are dark brown and woody, while stems are trigonous, green and smooth. Chemically revealed that, its consist of alkaloids, flavonoids, glycosides, phenols, tannins, steroids, starch and many novel sesquiterpenoids. In Asian countries, the rhizomes of C. rotundus, which are used as traditional folk medicine for the treatment of various ailments like amenorrhea, loss of appetite, colic, constipation, cough, diarrhea, dysentery etc.
Keyword: Cyperus rotundus, weed, rhizomes, traditional folk medicines and Disease
Evaluating the effectiveness of first-Line anti-tuberculosis in Al Dhafra Hospitals
Authors: Moetemed Mahmoud Shaaban , ALakkad Ashraf , Abdalla Hesham Abdalla 
Published: August 2023

Background: Tuberculosis (TB) continues to be a significant public health issue despite extensive efforts to control it. The standard treatment for TB involves the use of first-line anti-TB drugs administered at a standard dose. However, the effectiveness of this treatment can vary between individual patients, resulting in differing cure rates.
Methodology: The objective of this retrospective study was to assess the effectiveness and safety of first-line generic anti-TB medications administered at Liwa Hospital in the Al Dhafra Region. Data was collected from the electronic medical records of 140 TB patients admitted to Liwa Hospital from January to December 2022. The study included patients with positive acid-fast bacillus (AFB) or polymerase chain reaction (PCR) test results, indicating active TB infection. Patients resistant to first-line anti-TB medications or with lung cancer were excluded. Data collected included demographic information, length of stay conversion time, hospital admission, prescribed medications, treatment duration, and treatment outcomes.
Results: This study observed an average length of stay of 21 days for patients treated with first-line generic anti-TB medications at Liwa Hospital. Over 80% of the patients were discharged within 30 days of admission, indicating a positive response to the medications. Approximately 13% of the patients required a longer duration of treatment and were discharged between 30 and 60 days after admission. Only 5% of the patients had a prolonged stay of over 60 days, most of whom had co-morbidities or rifampicin resistance, but achieved AFB conversion within three months. The average conversion time for patients was 25 days, with over 92% achieving conversion within two months.
Conclusion: This study demonstrated the efficacy and safety of first-line generic anti-TB medications in treating TB patients at Liwa Hospital. The majority of patients responded well to the medications, leading to discharge within 30 days.
Keywords: Tuberculosis, Ethambutol, Pyrazinamide, Rifampicin, Isoniazid, First line drugs, Anti TB drugs
Formulation development and characterization of Lecarnidipine hydrochloride niosomal transdermal patches
Authors: Padmaja B. , Shobha Rani S. 
Published: August 2023

The bioavailability of Lercanidipine Hydrochloride (LCP) is about 44% and half-life of the drug is about 4.6 hours. LCP due to its low therapeutic dose range of 2.5 to 20mg and substantial biotransformation in liver becomes it ideal molecule in development of transdermal therapeutic system. The primary objective of the present research work was to develop Niosomal transdermal patch (NP) of Lecarnidipine. The LCP nanoparticles were prepared by solvent evaporation method and the optimized Nanoparticles formulation has shown 225nm particle size with a polydispersity index (PDI) of 0.120. LCP patches were prepared by incorporating nanoparticles dispersion, using varying concentrations of polymers HPMC E5, HPMC 5cps, HPMC 15cps, Carbopol 734 and Sodium alginate using solvent casting techniques and further optimized by central composite design(CCD) the effect of polymer on the various physico-chemical characteristics and in-vitro drug release studies, ex-vivo skin permeation studies is studied. On the basis of in-vitro drug release and ex-vivo skin permeation studies, the formulation containing (HPMC 15cps and HPMC 5cps) has shown sustained and extended drug release over a period of 24 hrs.
Keywords: Lecarnidipine; Niosomes; Transdermal patch; Central composite Design, Controlled release; Bioavailability etc.
Prevalence of Thyroid Disorders among Somali Women of Childbearing Age at Mogadishu, Somalia
Authors: Abdiaziz Abdullahi Abdulkadir , Osman Ebar Mohamed Hassan 
Published: August 2023

Background: Thyroid diseases are among the most prevalent of medical conditions, and considered the most prevalent disorders in women during their most fertile years (15 - 35 Years), and can adversely affect obstetric outcomes. The aim of the study was to determine the frequency of Thyroid dysfunction disorders among among Somali Women of Childbearing Age at Mogadishu, Somalia.
Materials and methods: This study was descriptive cross-sectional Hospital-based study conducted at Jazeera University Hospital, Mogadishu, Somalia during the period of December 2022 to April 2023. a total of 100 subjects were included in the study. A total of five ml of whole blood was collected from each participant into sterile plain containers for thyroid hormones estimation. Estimation of thyroid hormones was done by using ELISA machine (Maglumi 800). The data was gathered using per-designed structural questionnaire and the SPSS 26.0 statistical software (SPSS Inc., USA) was used for statistical analysis.
Results: The age of the study population ranges from 15–40 years with a mean age of 25.4 ± 8.11 years. There was insignificant correlation between the age and the frequency of thyroid dysfunction with P-value of 0.453. According to their BMI maximum respondents 42 (42%) were grouped under normal BMI, 40 (40%) respondents were over weighted, 2 (2%) of the respondents were grouped underweight and 16 (16%) were obese. The family history of thyroid dysfunction was found in 51% of the study population where 49% of them had no family history of thyroid dysfunction. For the laboratory diagnosis, maximum respondents were Euthyroid 87 (87%) followed by 8(8%) of respondents, were hyperthyroid and 5(5%) respondents had hypothyroid.
Conclusion: This study concluded that there is a slightly higher frequency of thyroid dysfunction disorders among Somali Women of Childbearing Age.
Keywords: Thyroid dysfunction, hyperthyrodism, hypothyrodism, childbearing age
Effect of Acne Vulgaris and its Impact on Quality of Life of Adolescents in Bengaluru
Authors: Shabnam Shabnam , Rashid Basharat , Mannan Mohd Nazir , Rahman Anisur 
Published: August 2023

Background and Objective: Acne vulgaris is a chronic condition affecting more than 85% of adolescents and young adults. This study was conducted to assess the prevalence of acne vulgaris and its impact on quality of life (QoL) and to study socio-demographic factors, family history and lifestyle among the selected schools at Jalahalli area in Bengaluru. Materials and Methods: This study was a descriptive cross sectional school based study and 200 subjects were included. Predesigned, questionnaire to assess socio-demographic profile and QoL and symptoms of acne vulgaris were administered to the participants fulfilling inclusion criteria. Data were obtained by using different methods such as Global Acne Grading System (GAGS), Cardiff Acne Disability Index and Children’s Dermatology Life Quality Index/Dermatology Life Quality Index (CDLQI/DLQI) respectively. SPSS 18.0 software was used for data analysis. Results: Findings showed that Acne prevalence was 87% affecting both sexes. Self-reported mild acne was present in 85.1% and moderate severe acne in 14.9% of the adolescents. The mean age of the subjects was 14.78 years, with 52.5% females and 47.5% males. A strong relation was found between the severity of acne and QoL (p<0.001). Heredity was correlated with acne and its severity was significant. Conclusion: Acne affects the QoL of an adolescent, and the impact is proportional to the severity of acne. Severe acne is associated with a greater effect on QoL. Evaluation of QoL in such patients may greatly help in the better management of acne, hence improving their quality of life.
Keywords: Acne vulgaris; Adolescent; Quality of life; GAGS; CDLQI; DLQI.
Effect of Gallic Acid Treatment on Hepatic Tissue in Ischemia-Reperfusion
Authors: Durgun Cemalettin , Deveci Engin 
Published: August 2023

Aim: Hepatic IR occurs in many clinical conditions such as liver injury, liver hemorrhage and shock, surgical resection, and transplantation. In our study, it is aimed to investigate whether gallic acid (GA) can be used for hepatoprotective purposes, histopathologically.
Study Desıgn: 24 Wistar albino male rats were divided into 3 groups (n:8). Surgical procedures were done under general anesthesia. A 4 cm midline abdominal incision were opened to observe hepatoduodenal ligament. The portal vein and hepatic artery was closed with a rubber band and silk suture, and ischemia was performed for 60 minutes. The suture was opened and hepatic reperfusion was performed for 6 hours. 50 mg/kg Gallic Acid was administered to the rats in this group by intraperitoneal route once a day for 14 days.
Results: Normal histology of lvier was observed with regular vena centralis, endothelial cells, hepatocytes and sinusoid. In IR group, blood vessels were dilated and congested with cell infiltrations. Hepatocytes were degenerated with irregular sinusoides and hyperplasic Kupfer cells. IR+GA group, mononuclear cell infiltration continued with thickening of the basement membrane of the vessels. Vacuolated hepatocyte was observed. GA treatment alleviasted the pathologies occurred due to IR injury.
Conclusion: It was thought that the cellular damage in the inflammation signal, which started as a result of the cessation of blood flow after ischemia-reperfusion injury, affects the classical lobule of the liver especially around the vena, and may cause necrotic changes by increasing cell apoptosis due to functional nutritional deficiency.
Keywords: liver, ischemia, reperfusion, gallic acid, histology
Phytochemistry and Antiperoxidative Potential of Cannabis sativa L. Leaves Methanol Extracts: An In Vitro Study
Authors: Saxena Anjani , Puranik Nitin 
Published: August 2023

Aim: Present study aimed to demonstrate the preliminary phytochemical composition, antioxidant and in vitro protective potential of the methanolic extract of Cannabis sativa L.
Study Design: A methanolic extract of Cannabis sativa L. leaves was prepared and assessed at the in vitro level for its preliminary phytochemical screening and antiperoxidative potentials by using the DPPH radical reduction assay, lipid peroxidation inhibitory activity, protein carbonyl inhibitory potential in glycated bovine serum albumin, and enzyme antioxidant activity in a goat liver homogenate system exposed to hydrogen peroxide as oxidant molecule.
Results: The methanolic extract of Cannabis sativa L. leaf contained a diverse range of phytoconstituents, including alkaloids, flavonoids, tannins, terpenoids, and saponins. Upon quantitative analysis, the methanolic extract of C. sativa L. reflected 50 ± 0.013 µg quercetin equivalent / mg of extract according to the querecetin standard graph, while 28.03 ± 0.024 % alkaloid content was retrieved after quantification.
Conclusion: We suggest that, upon tested on all in vitro antioxidant parameters; the leaf methanolic extract of Cannabis sativa L. demonstrated potent antioxidant and protective activity.
Keywords: Cannabis sativa L., Antioxidant, in vitro, DPPH, LPO, Protein carbonyl, peroxidative potential
Management of risk factors and pharmacological therapy in oral pemphigus vulgaris: A Case Report
Authors: Nuraeny Nanan , Setiadhi Riani 
Published: August 2023

Introduction: The incidence of pemphigus vulgaris is rare. It often occurs in middle age and the elderly or in the 4th to 5th decades. Women experience it more often than men. Pemphigus vulgaris predominates in patients of Ashkenazi Jewish, Asian or Mediterranean descent. The etiology of pemphigus vulgaris remains unclear, but it can be triggered by several risk factors, such as drugs, radiation, surgery, and some foods. This case report aims to describe a case of oral pemphigus vulgaris caused by stress and food and its management. Case: a 45-year-old woman who was hospitalized at Dr. Hasan Sadikin hospital referred from Dermatology and Venerology department to Oral Medicine department with diagnosis pemphigus vulgaris. The risk factors were emotional stress and food preservated. Pharmacology therapy including steroids, anti-fungal, and vitamins. Discussion: The management of this patient was carried out by a multidisciplinary team, dermatologist collaborate with oral medicine specialist to support comprehensive therapy. Identification and controlling emotional stress and cessation of food which was suspected as the cause, were the important aspect as an addition to the given pharmacological therapy led to significant improvement of oral pemphigus vulgaris. Conclusion: Oral pemphigus vulgaris as a chronic autoimmune disease can be cured if the risk factors can be controlled and close monitoring of pharmacological therapy can be carried out by a team.
Keywords: pharmacology, risk factor, oral pemphigus vulgaris
The Relationship Between Fear, Loneliness, and Depression Among University Students: A Structural Equation Model
Authors: Abu Shind Yousef Abdelqader , Al-Bahrani Muna Abdullah , Alkharusi Hussain Ali 
Published: August 2023

The aim of this study was to test the causal relationship among fear of Covid-19, loneliness, and depression from Covid-19. The study sample consisted of 605 undergraduate students recruited from a public university. They completed three scales: fear of Covid-19, depression from Covid-19, and loneliness. The results revealed a good fit index for the proposed path model. The fear of Covid-19 predicted two types of loneliness emotional and social negatively. A positive association between depression and emotional as well as social loneliness was found. A total of 43% of the variance in depression was explained by loneliness. Depression was potentially a mediating factor between a fear of pandemic and the feeling of loneliness. A counseling intervention can be designed based on these results.
Increasing of oral health education knowledge after intervention psychoeducation methods in adolescents
Authors: Yubiliana Gilang , Kusumah Salsabila Putri , Abdurrochman Andri 
Published: August 2023

ABSTRACT Introduction: The technique of imparting knowledge and understanding known as "psychoeducation" combines particular knowledge with media to communicate knowledge, is professionally provided, and integrates educational and psychotherapy treatments. Given the close connection between oral health and general health, oral health should not be neglected during the pandemic. Through the use of psychoeducational techniques, dental health issues can be prevented and overcome. The objective of this study is to analyze the increase in oral health education knowledge before and after intervention using psychoeducation methods in adolescents. Methods: This research was conducted using the one group pretest-posttest design. A study sample was obtained using the Slovin formula after a population was sampled using purposive sampling. The following requirements must be met in order for students to be included in the sample: they must be concerned about their oral health, be open to participating in psychoeducation webinars, and agree to participate as research subjects. There were 86 responses in the sample. By providing a questionnaire before (pretest) and after (posttest) the intervention in oral health education using psychoeducation method, the increase in knowledge can be measured. Results: The results of the Wilcoxon signed rank test with an alpha significance of 0.05 and Asymp. Sig (two-tailed) p = 0.001 (p < 0.05), or the knowledge factors of research respondents. This revealed significant improvements in respondents' knowledge between the pre- and post-intervention periods. Conclusion: The intervention of psychoeducational methods regarding oral health education could increase knowledge in adolescents. Psychoeducational methods can help adolescents learn more about oral health.