bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study of primary caesarean section among multigravida in a tertiary care hospital
Authors: Kumar Rajesh , Chaudhary Rachna , Dhama Vandana , Singh Shakun 
Published: February 2023

Background: Primary caesarean section in multigravida refers to first time caesarean section in multiparous women who have had previous one or more vaginal delivery. The study focused on the frequency, indication, intra operative and postoperative complications, maternal and fetal outcome of primary caesarean section in multiparous women with previous vaginal deliveries.
Methods: It was a prospective study of all the cases of primary caesarean section in multigravida admitted at LLRM Medical College Meerut, Uttar Pradesh over period of 1 year from January 2021 to December 2021.
Results: Total number of deliveries during the study period of 1 year was 5670 and total no of caesarean section was 2432 with a caesarean rate of 42.89%. Out of 2432 caesarean section 488 (20.10%) were done in primigravida and 253 (10.40%) in multigravida. In present study most common indication for caesarean section was malpresentation 68 (26.86%) followed by severe oligohydramnios in 47 (18.57%). Most common maternal complication was pyrexia in 24 (9.48%). Most common morbidity were due to preterm 65 (22.13%) neonates followed by RDS in 22 (8.69%) neonates.
Conclusions: Though responsible for least number of overall caesarean section, multiparous subjects undergoing primary caesarean section is high risk pregnancy with possibility of adverse obstetric outcome in significant number of subjects and hence multiparous women deserve the same attention during pregnancy and labour as primigravida and women with repeat caesarean section.
Pelaksanaan Perlindungan Kesehatan dan Keselamatan Kerja Terhadap Pekerja Perseroan Terbatas
Authors: Utomo Jalu Ario Setyo , Karjoko Lego 
Published: February 2023

<em>This research is come from the importance of human resources in doing work. The factor that easily affects human resources in terms of production is Occupational Health and Safety (K3). Factors that influence the implementation of Occupational Safety and Health (K3) at PT. Halo Indonesia Manufacture, namely personal protective equipment (PPE), warning signs, human resources (HR) and technology. The implementation of Occupational Safety and Health (K3) at PT. Halo Indonesia Manufacture, namely establishing an Occupational Safety and Health Management System (SMK3), preventing and reducing accidents, extinguishing fires, providing aid in accidents, providing personal protective equipment to employees and providing training on work safety.</em>
Factors Affecting Buffaloes’ Farmers Commitment toward Accessibility of Resources in Pemalang District, Central Java, Indonesia
Authors: Muatip Krismiwati , Purwaningsih Hermin , Enstein Alief , Djatmiko Oentoeng Edy , Mastuti Sri , Hidayat Nunung Noor , Widiyanti Rahayu , Wakhidati Yusmi Nur , Safitri Lis , Cahyo Danang Nur 
Published: February 2023

This study was aimed to measure the farmers' commitment, accessibility of resources (information, capital, and assistance), and the correlation between those variables. The research method used in the current study was the survey method. The location was purposively selected in Pemalang Regency, the regency with the largest buffalo population in Central Java Province. Three subdistricts (20%) with formal and informal farmers' groups were selected, and there were Taman, Pemalang, and Belik subdistricts. One Village was selected for each subdistrict. Respondents for informal groups were taken by census method. Respondents in formal groups were taken by random sampling, and the number of respondents followed the number of informal groups. There were 136 farmers selected as respondents. (69 from each formal and informal groups). The data were analyzed using the descriptive and rank Spearman correlation methods. The results showed that the farmers' commitment of formal group and informal group members was in the moderate and low categories respectively based on the percentage score interval scaling method. Resources accessibility of formal and informal members of the farmers' group was in the low to moderate category, but the member of formal groups was slightly better. There was a strong correlation between the accessibility of resources with the commitment in the formal groups, whereas in the informal groups there was a moderate to strong correlation between the accessibility of resources with the commitment of buffalo farmers. Based on the conclusion, this study recommend that the government should assist the informal farmer group to establish formal group with the result that would increase farmers accessibility toward information, support, and capital. That condition would increase farmers commitment to continue their buffalo farm business in Pemalang Regency.
Utilization of Different Concentration Sugarcane Molasses to the Quality of Goat Feces-Chicken Excreta-Coconut Husk Organic Liquid Fertilizer
Authors: Priyadi Dwi Ahmad , Toni Sefri , Istanti Ari 
Published: February 2023

Indonesia is an agricultural country that certainly has the potential for agricultural waste and by-products. Some of those in Indonesia are livestock manure, coconut husk, and sugarcane molasses. Utilization of this waste is limited, which is causing various environmental problems such as environmental pollution. The study is aimed to determine the quality of organic liquid fertilizer made by raw material from goat feces-chicken excreta-coconut husk with various sugarcane molasses concentrations (P0= 0%; P1= 5%; P3= 15%; P4= 20%; P5= 25%). The fermentation was carried out anaerobically for 21 days. The parameters of temperature, pH, organoleptic (color and odor), levels of C-organic, nitrogen (N) total, phosphorus (P) total, potassium (K) total, and biological tests were observed. Biological tests were conducted in the growth of mung bean (Vigna radiata) and spinach (Amaranthus tricolor). Data were analyzed using one-way ANOVA. Variations in the addition of molasses sugarcane did not affect the liquid fertilizer's temperature and pH during fermentation. However, the treatments had positive effect on organoleptic test, C-organic, N total, P total, K total, and biological tests. The addition of 15% sugarcane molasses (P3) showed a dominating performance toward most of the parameters tested. The P3 treatment produced liquid fertilizer with a pleasant smell, and the contents of C-organic, total N, total P, and total K were 2.12%, 0.25%, 0.13%, and 0.13%, respectively. and produce spinach as a biological test with plant height, number of leaves, leaf width, stem diameter, and root length were 21.82 cm, 6.66 sheets, 3.59 cm, 4.09 mm, and 14.67 cm, respectively.
A novel technique for encoding images using Chen model and computer-generated holograms
Authors: Ali Nabaa , Jamal Raied K. 
Published: February 2023

Abstract
In this work, computer-generated hologram technology was used to encode information and link it to one of the chaotic system models (Chen), using the Matlab program. The results showed that the information (images) can be easily identified using computer-generated holograms through the process of computer holographic reconstruction of the images to be encrypted, and this process is undesirable in secure communications, But when linking with the chaotic Chen system through several mathematical operations including addition, multiplication and division, the resulting holograms of the image to be encrypted and the hologram of the Chen system, where the results showed complete encryption of the images to be encrypted and the disappearance of their features using the division process.
The Demand for Healthy Aging Services among Young and Middle-Aged People in Zhuang inhabited Regions and its influencing factors: A cross-sectional study
Authors: Ouyang Ziyao , Fan Dengjing , Su Lin , Li Gaopeng , Pan Xiao , Chen Lin , Pan Yanfei , Li Caili , Tao Pinyue , Huang Huiqiao 
Published: February 2023

Abstract
Background
Although policy actions and strategic efforts have recognized the importance of healthy aging services for Chinese older adults, supply and utilization remains low.
Aims
To analyze the demand and influencing factors for healthy aging services among young and middle-aged people in the Zhuang-inhabited area in Guangxi province.
Methods
A cross-sectional survey was conducted with 1,731 participants in Guangxi, which comprised demographic and healthy aging services demand questionnaires.
Results
The top three demands were legal aid, pension fund, and pension environment. Age, ethnicity, and occupation were the common influencing factors of healthy aging services for young and middle-aged people. Furthermore, various factors affected each dimension of demand, showing a trend of individualization and diversification.
Conclusion
It is urgent to establish a prediction model of healthy aging demand for young and middle-aged people. Moreover, the government should implement activities to reform healthy aging services and the distinct service needs in Guangxi.
Surgical Outcomes of Standardized Endoscopical Deep Medial Orbital Decompression in Dysthyroid Optic Neuropathy
Authors: Li Cheng , Gao Yang , Zhang Zhihui , Lv Xi , Bao Yuekun , Ma Yujun , Chen Rongxin , Cheng Chao , Li Jinmiao , Liu Yaoming , Jin Ling , Luo Guangwei , Shi Jianbo , Lu Rong 
Published: February 2023

Abstract
Objectives: To standardize the endoscopic deep medial orbital decompression surgery for better relief of optic nerve compression in dysthyroid optic neuropathy (DON).
Methods: A total of 128 eyes from patients received the standardized endoscopic deep medial orbital decompression surgery were recruited in this study. The efficacy of the procedure was assessed at a one-month follow-up by the best-corrected visual acuity (VA), visual field (VF), and visual evoked potential (VEP). Clinical data were collected to explore the factors that affected visual recovery. Oxygen saturation of retinal blood vessels, retinal thickness, and vessel density were measured to demonstrate the potential recovery mechanisms.
Results: After surgery, the ratio of extraocular muscle volume in the orbital apex to orbital apex volume significantly decreased from 44.32 ± 22.31% to 36.82 ± 12.02% (P < 0.001). 96.87% of eyes’ final VA improved, average VA improved from 0.93 ± 0.73 to 0.50 ± 0.60 at 1 week (P < 0.001) and 0.40 ± 0.53 at 1 month (P < 0.001). Postoperatively VF and VEP also improved, the oxygen saturation of retinal arteries increased, and the retinal thickness was reduced. Preoperative VA, visual impairment duration, and clinical activity score evaluation were associated with visual recovery.
Conclusions: In this study, we standardized the endoscopic deep medial orbital decompression, of which key point was to relieve pressure in the orbital apex and achieved satisfactory visual recovery in DON patients.
Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast
Authors: Domenzain Iván , Lu Yao , Shi Junling , Lu Hongzhong , Nielsen Jens 
Published: February 2023

Abstract
Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case-specific strategies, based on the product and microbial host of interest. Despite major advancements in the field of metabolic modelling in recent years, prediction of genetic modifications for increased production remains challenging. Here we present a computational pipeline that leverages the concept of protein limitations in metabolism for prediction of optimal combinations of gene engineering targets for enhanced chemical bioproduction. We used our pipeline for prediction of engineering targets for 102 different chemicals using Saccharomyces cerevisiae as a host. Furthermore, we identified sets of gene targets predicted for groups of multiple chemicals, suggesting the possibility of rational model-driven design of platform strains for diversified chemical production.
The state of the incidence and mortality of hepatitis B in China from 2004 to 2021: A spatiotemporal characteristics and trend analysis
Authors: Zhang Mengge , Li Chuancang , Cai Qian , Qu Mengbing , Meng Jingjing , Fan Haohao , Sun Liang 
Published: February 2023

Abstract
Objective: To describe the spatiotemporal characteristics and trend of incidence and mortality of hepatitis B in China from 2004 to 2021 and to identify its possible hotspots and potential high-risk areas for the disease.
Methods: Time trends in hepatitis B incidence and mortality were analyzed using Joinpoint regression models, and annual percentage change (APC) and average annual percentage change (AAPC) were calculated stratified by age. The spatial autocorrelation analysis of GeoDa and the space-time scanning analysis of SaTScan software were used to identify potential changes and regional differences in the spatial and temporal distribution of hepatitis B humans in China during the study period.
Results: From 2004 to 2021, the number of hepatitis B cases in China increased from 916,396 in 2004 to 976,233 in 2021 (AAPC=0.31%, P=0.665), and the number of deaths decreased from 783 in 2004 to 413 in 2021 (AAPC=-3.23%, P =0.076). There was an increasing trend of standardized incidence of hepatitis B in the age group over 30 years. The High-High cluster areas of incidence rate of hepatitis B in China from 2004 to 2012 were mainly concentrated in the northwest,and in the southeast from 2017 to 2021 were concentrated, while the High-Low cluster areas of mortality rate of hepatitis B were mainly concentrated in Beijing and Shanghai from 2004 to 2019.The results of space–time cluster analysis for incidence rate of hepatitis B in China from 2004 to 2018 included one primary clustering area and two secondary clustering areas. The primary clustering area was located in the west of China, including Tibet, Qinghai, Xinjiang and Gansu, and the high-risk time frame was from January 2006 to December 2012 (RR = 2.78, LLR = 300786.49, P  < 0.001). The results of space–time cluster analysis for mortality rate of hepatitis B in China from 2004 to 2018 included one primary clustering area and two secondary clustering areas. The primary clustering area was located in Beijing of China, and the high-risk time frame was from January 2007 to December 2013 (RR = 12.14, LLR = 1120.197907, P  < 0.001).
Conclusion: The overall trend incidence and mortality of hepatitis B in China has decreased over the 18-year period, but the number of hepatitis B incidences is on the rise. The spatial distribution of hepatitis B incidence rate in each region of the country had spatial positive correlation.Hepatitis B incidence and mortality rates vary widely in China with different epidemiologic trends affecting different locations and revealing different spatial changing patterns.
Impacts of development of acute-on-chronic liver failure and bacteria infections on pancreatic β-cell function and glucose homeostasis in patients with liver cirrhosis
Authors: Liu Yujuan , Hu Han , Li Chuan , Zhang Yin , Li Meichuan , Lu Tao , Wu Yunchong , Yang Yanyan , Li Ying , Yang Fangwan , Shi Xiuquan , De Lin Shi 
Published: February 2023

AbstractBackground/PurposeGlucose metabolism disorders (GMDs), including diabetes and impaired glucose tolerance, is a common complication and associated with poor prognosis in patients with liver cirrhosis. The aim of this study was to investigate the impacts of development of acute-on-chronic liver failure (ACLF) and bacteria infections (BIs) on pancreatic β-cell function and glucose homeostasis in patients with acute deterioration of liver cirrhosis.MethodsThree hundred and twenty seven patients with acute deterioration of liver cirrhosis were retrospectively included. Oral glucose tolerance test (OGTT) and OGTT-based β cell function indices were used to evaluate pancreatic β-cell function and disturbance in glucose homeostasis. Univariate and multivariate logistic regression were used to identify independent risk factors associated with GMDs.ResultsDevelopment of ACLF or BIs significantly increased the prevalence of GMDs. ACLF or BIs also significantly increased level of homeostasis model of assessment 2-insulin resistance (HOMA2-IR). ACLF but not BIs significantly impaired the glucose-stimulated insulin secretion as assessed using insulinogenic index (IGI). Patients with GMDs had a significantly lower level of IGI than that in patients without GMDs. Prothrombin activity (OR=0.981, 95% CI: 0.960~0.995), HOMA2-IR (OR=1.749, 95% CI: 1.130~2.707) and IGI (OR=0.963, 95% CI: 0.947~0.978) were the independent risk factors associated with GMDs in patients with acute deterioration of liver cirrhosis.ConclusionsIn patients with liver cirrhosis, development of ACLF impairs glucose-stimulated insulin secretion of pancreatic β-cell, both liver impairment and BIs increase insulin resistance and contribute to aggravation of disturbance in glucose
Differences in Cardiac Rupture and Hemopericardium Caused by Blunt Chest Injury, Acute Myocardial Infarct, Aortic Dissection and CPR
Authors: Xiao Ning , Miao Qi , Zhang Yan-Lin , Yu Yan-Geng , Zhang Fu , Li Dong-Ri 
Published: February 2023

Abstract
Objective
In this study, the hemopericardium volume and pathological characteristics associated with cardiac ruptures caused by blunt violence, AMI, aortic dissection and CPR have been analyzed. The findings might provide reference and data support for deciphering the cause of heart rupture in forensic pathology.
Method
Pericardial water-injection tests were conducted in 22 noncardiac death subjects. Other study groups included 9 cases of myocardial infarction, 20 cases of aortic dissection rupture, 11 cases of cardiac rupture caused by trauma and 4 cases of cardiac rupture by CPR. The volume of hemopericardium and the pathological features were analyzed for each group.
Result
The hemopericardium volume in myocardial infarction and dissecting aneurysm rupture were significantly higher than the pericardial injection test in noncardiac subjects (p-value < 0.01). The traumatic cardiac rupture cases had a large range in hemopericardium volume and no significant difference was observed with respect to non-cardiac death cases (p-value > 0.05). The volume of hemopericardium in CPR-induced cardiac rupture had no difference with non-cardiac rupture and it was significantly lower than the pericardial injection test (p-value < 0.01).
Conclusion
Differences in the volume of hemopericardium induced by different causes of cardiac rupture were observed. It may be related to the state of the cardiac systolic functions during an event of a rupture. The volume of hemopericardium can be used as reference data to determine the mechanism of the rupture. This could also be beneficial in cases of cardiac rupture with similar morphological and pathological features such as severe blunt chest injury and CPR.
Investigating of Risk Factors Associated with Exposure to Road Traffic Accidents among Drivers, El-Obeid, North Kordofan State, Sudan; A Cross-sectional Study
Authors: Mohammed Musa , Abdullahi Abdirahman , Barakat Abdollh 
Published: February 2023

Abstract
Background and objective: Road traffic accidents (RTA) represent a major important public health problem in our country and play a major role in lifelong disabilities as well as high mortality. In Sudan, the rate of road traffic accidents has recently increased for reasons related to excessive speed, and the collapse of most national roads.
Materials and Methods: A cross-sectional descriptive study of all vehicles drivers. It was carried out in Jun 2017 to January 2018, to study of risk factors associated with road traffic accidents. Data were entered and analyzed using the Statistical Package of Social Sciences (SPSS) version (16.0) and Microsoft Excel (2010) software. Chi-square (χ2) was used to determine whether there is a significant association between different variables. Values were considered to be statistically significant when the p-value obtained was less than (0.05) and assessed strength of correlation using Odd Raito (OR) with 95% confidence intervals (CI).
Results: The study included (296) vehicles drivers, all drivers who were interviewed were male. Majority (87.8%) of them has a driving license and (51%) use a seat belt while driving. Use earphones (MP3) while driving [p= 0.001, OR 22.241; 95% CI (21.896, 22.606)], use cell phone while driving [p= 0.001, OR 21.430; 95% CI (21.182, 21.726)], doping consumption [p= 0.001, OR 21.488; 95% CI (21.194, 21.791)], alcohol drinking [p= 0.001, OR 20.737; 95% CI (20.501, 20.971)], use drugs [p= 0.001, OR 22.241; 95% CI (21.877, 22.631)], suffering from low vision [p= 0.001, OR 20.794.665; 95% CI (20.553, 21.033)] and condition of the brakes[p= 0.052, OR 20.754; 95% CI (20.515, 20.977)] were significantly associated with RTAs.
Conclusion: There is need for accelerate the of laws against stimulants consumption and excessive speed among vehicles drivers and motorcyclists during driving by local authorities in order to reduce RTAs.
Big cats like water: occupancy patterns of jaguar in a unique and insular Brazilian Amazon ecosystem
Authors: Duarte Herbert Barbosa , Carvalho William Mustin , Toledo José Julio , Rosalino Luis Miguel 
Published: February 2023

Abstract
Patterns of detectability and occupation of the jaguar (Panthera onca) vary throughout its distribution, being determined primarily by vegetation cover, prey availability, and anthropogenic factors. However, there is still a large knowledge gap regarding what determines jaguar occupancy, especially in the Amazon. This knowledge gap is even more pronounced for oceanic islands, which represent unique and very sensitive ecosystems, such as the Maracá-Jipioca Islands of the Northeastern Brazilian Amazon. Our study aimed to establish the spatial ecology of jaguars in this insular ecosystem and to provide information to facilitate sustainable management of the population there. We assessed how different factors (vegetation type and prey availability) potentially influence detectability and occupancy patterns of the jaguars of the Maracá-Jipioca Islands. We found that greater wetland (beach-sea and lagoon-channel) cover was the main driver of jaguar detectability and occupancy. We reveal factors driving the population and spatial ecology of jaguars in an insular system. Despite imminent threats to the region, the knowledge we present can inform the sustainable management of jaguars to ensure that the fundamental and unique ecosystem services provided by this top predator are maintained.
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt- mTOR signaling
Authors: Jaime Diego , Fish Lauren A. , Madigan Laura A. , Ewing Madison D. , Fallon Justin R. 
Published: February 2023

Abstract
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at all neuromuscular junctions and is also present extrasynaptically in the slow soleus muscle. To investigate the role of the MuSK-BMP pathway in vivo we generated mice lacking the BMP-binding MuSK Ig3 domain. These ∆Ig3-MuSKmice are viable and fertile with innervation levels comparable to wild type. In 3-month-old mice myofibers are smaller in the slow soleus, but not in the fast tibialis anterior (TA). Transcriptomic analysis revealed soleus-selective decreases in RNA metabolism and protein synthesis pathways as well as dysregulation of IGF1-Akt-mTOR pathway components. Biochemical analysis showed that Akt-mTOR signaling is reduced in soleus but not TA. We propose that the MuSK-BMP pathway acts extrasynaptically to maintain myofiber size in slow muscle by promoting protein synthetic pathways including IGF1-Akt-mTOR signaling. These results reveal a novel mechanism for regulating myofiber size in slow muscle and introduce the MuSK-BMP pathway as a target for promoting muscle growth and combatting atrophy.