bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arbovirology and Cold War Collaborations: A Transnational History of the Tick-borne Encephalitis Vaccine, 1930-1980
Authors: Mazanik Anna 
Published: September 2023

Abstract
This article analyzes the history of immunization against tick-borne encephalitis (TBE) and specifically the processes that led to the creation and application of TBE vaccines in the Soviet Union and Austria. Rather than presenting the development of TBE vaccines from the perspective of national scientific schools, the article investigates their history as a transnational project, focusing on the connections among the Soviet Union, Czechoslovakia, Austria, the United States, and the United Kingdom. It argues that biomedical research on TBE was profoundly intertwined with political and military agendas and depended on civil international cooperation as well as Soviet, American, and British military concerns, infrastructures and funding. The article consists of four parts that discuss (1) the identification of the TBE virus and the creation of the first TBE vaccine in the Soviet Union in the 1930s; (2) the internationalization of TBE research and vaccine development in the 1940s-1960s; (3) the history of TBE research and virology in Austria in the 1930s-1960s and the role of the US military funding; and (4) the cooperation of Austrian virologist Christian Kunz with the Microbiological Research Establishment Porton Down in the UK leading to the development of the Austrian/British vaccine against TBE in the 1970s.
Facing up to face value: Communication, difference, and the turn to expertise
Authors: Ashcraft Karen Lee 
Published: September 2023

Abstract
This paper engages with a turn that has taken place over the last decade or so: from a sociology of professions toward a sociology of expertise. While the shift toward expertise is highly conducive to communicative inquiry, it is haunted by a ghost of professions past. I argue that this ghost—a persistent problem I formulate as ‘face value’—must be confronted for the turn to realize its considerable potential. Face value refers to the ways in which presumptions of merit arise through relations of difference, such as gender, race, and sexuality. I chart a path toward examining the production of face value, namely, by situating networks of expertise within economies of difference.
Stationary nonseparable space-time covariance functions on networks
Authors: Porcu Emilio , White Philip A , Genton Marc G 
Published: September 2023

Abstract
The advent of data science has provided an increasing number of challenges with high data complexity. This paper addresses the challenge of space-time data where the spatial domain is not a planar surface, a sphere, or a linear network, but a generalised network (termed a graph with Euclidean edges). Additionally, data are repeatedly measured over different temporal instants. We provide new classes of stationary nonseparable space-time covariance functions where space can be a generalised network, a Euclidean tree, or a linear network, and where time can be linear or circular (seasonal). Because the construction principles are technical, we focus on illustrations that guide the reader through the construction of statistically interpretable examples. A simulation study demonstrates that the correct model can be recovered when compared to misspecified models. In addition, our simulation studies show that we effectively recover simulation parameters. In our data analysis, we consider a traffic accident dataset that shows improved model performance based on covariance specifications and network-based metrics.
Characterization of rhizobia for beneficial traits that promote nodulation in legumes under abiotically stressed conditions
Authors: Khambani Langutani Sanger , Hassen Ahmed Idris , Rumbold Karl 
Published: September 2023

Abstract
The growing interest in using rhizobia as inoculants in sustainable agricultural systems has prompted the screening of rhizobia species for beneficial traits that enhance nodulation and nitrogen fixation under abiotic stressed conditions. This study reports phenotypic and phylogenetic characterization of rhizobia strains previously isolated from the root nodules of several indigenous and exotic legumes growing in South Africa and other countries. The Rhizobia strains were screened for their ability to tolerate various abiotic stresses (temperature 16, 28, and 36 °C; acidity/alkalinity pH 5, 7, and 9; heavy metals 50, 100, and 150 mM AlCl3.6H2O; and salinity 50, 100, and 150 mM NaCl). Phylogenetic characterization of the isolates was determined using multilocus sequence analysis of the 16S rRNA, recA, acdS, exoR, nodA, and nodC genes. The analysis indicated that the isolates are phylogenetically related to Sinorhizobium, Bradyrhizobium, Rhizobium, Mesorhizobium, and Aminobacter genera and exhibited significant variations in their tolerance to abiotic stresses. Amid the increasing threats of the global stresses, these current results provide baseline information in the selection of rhizobia for use as inoculants under extreme temperatures, acidity/alkalinity, and salinity stress conditions in South Africa.
An HST COS ultraviolet spectroscopic survey of 311 DA white dwarfs – I. Fundamental parameters and comparative studies
Authors: Sahu Snehalata , Gänsicke Boris T , Tremblay Pier-Emmanuel , Koester Detlev , Hermes J J , Wilson David J , Toloza Odette , Hoskin Matthew J , Farihi Jay , Manser Christopher J , Redfield Seth 
Published: September 2023

ABSTRACT
White dwarf studies carry significant implications across multiple fields of astrophysics, including exoplanets, supernova explosions, and cosmological investigations. Thus, accurate determinations of their fundamental parameters (Teff and log g) are of utmost importance. While optical surveys have provided measurements for many white dwarfs, there is a lack of studies utilizing ultraviolet (UV) data, particularly focusing on the warmer ones that predominantly emit in the UV range. Here, we present the medium-resolution far-UV spectroscopic survey of 311 DA white dwarfs obtained with Cosmic Origins Spectrograph (COS) onboard Hubble Space Telescope confirming 49 photometric Gaia candidates. We used 3D extinction maps, parallaxes, and hydrogen atmosphere models to fit the spectra of the stars that lie in the range $12\, 000 \lt \mbox{$T_{\mathrm{eff}}$}\lt 33\, 000$ K, and $7 \le \mbox{$\log g$}\lt 9.2$. To assess the impact of input physics, we employed two mass–radius relations in the fitting and compared the results with previous studies. The comparisons suggest the COS Teff are systematically lower by 3 per cent, on average, than Balmer line fits while they differ by only 1.5 per cent from optical photometric studies. The mass distributions indicate that the COS masses are smaller by ≈0.05  and 0.02 M⊙ than Balmer lines and photometric masses, respectively. Performing several tests, we find that the discrepancies are either arising due to issues with the COS calibration, broadening theories for hydrogen lines, or interstellar reddening which needs further examination. Based on comparative analysis, we identify 30 binary candidates drawing attention for follow-up studies to confirm their nature.
Halo scaling relations and hydrostatic mass bias in the
simba
simulation from realistic mock X-ray catalogues
Authors: Jennings Fred , Davé Romeel 
Published: September 2023

ABSTRACT
We present a new end-to-end pipeline for Mock Observations of X-ray Haloes and Analysis (moxha) for hydrodynamic simulations of massive haloes, and use it to investigate X-ray scaling relations and hydrostatic mass bias in the simba cosmological hydrodynamic simulation for haloes with M500 ∼ 1013−15M⊙. moxha ties together existing yT-based software packages and adds new functionality to provide an end-to-end pipeline for generating mock X-ray halo data from large-scale or zoom simulation boxes. We compare moxha-derived halo properties in simba to their emission-weighted counterparts, and forecast the systematic mass bias in mock Athena observations. Overall, we find inferred hydrostatic masses are biased low compared to true simba values. For simple mass-weighting, we find $b_\text{MW} = 0.15^{+0.15}_{-0.14}$ (16–84 per cent range), while emission-weighting increases this to $b_\text{LW}=0.30^{+0.19}_{-0.10}$. The larger bias versus mass-weighted values we attribute to the spectroscopic and emission-weighted temperatures being biased systematically lower than mass-weighted temperatures. The full moxha pipeline recovers the emission-weighted hydrostatic masses at R500 reasonably well, yielding $b_\text{X}=0.33^{+0.28}_{-0.34}$. moxha-derived halo X-ray scalings are in very good agreement with observed scaling relations, with the inclusion of lower mass groups significantly steepening the LX − M500, M500 − TX, and LX − TX relations. This indicates the strong effect the simba feedback model has on low-mass haloes, which strongly evacuates poor groups but still retains enough gas to reproduce observations. We find similar trends for analogous scaling relations measured at R500, as expected for halo-wide gas evacuation.
The role of tidal interactions in the formation of slowly rotating early-type stars in young star clusters
Authors: He Chenyu , Li Chengyuan , Sun Weijia , de Grijs Richard , Li Lu , Zhong Jing , Qin Songmei , Chen Li , Wang Li , Tang Baitian , Shao Zhengyi , Xu Cheng 
Published: September 2023

ABSTRACT
The split main sequences found in the colour–magnitude diagrams of star clusters younger than ∼600 Myr are suggested to be caused by the dichotomy of stellar rotation rates of upper main-sequence stars. Tidal interactions have been suggested as a possible explanation of the dichotomy of the stellar rotation rates. This hypothesis proposes that the slow rotation rates of stars along the split main sequences are caused by tidal interactions in binaries. To test this scenario, we measured the variations in the radial velocities of slowly rotating stars along the split main sequence of the young Galactic cluster NGC 2422 (∼90 Myr) using spectra obtained at multiple epochs with the Canada–France–Hawai’i Telescope. Our results show that most slowly rotating stars are not radial velocity variables. Using the theory of dynamical tides, we find that the binary separations necessary to fully or partially synchronize our spectroscopic targets, on time-scales shorter than the cluster age, predict much larger radial velocity variations across multiple-epoch observations, or a much larger radial velocity dispersion at a single epoch, than the observed values. This indicates that tidal interactions are not the dominant mechanism to form slowly rotating stars along the split main sequences. As the observations of the rotation velocity distribution among B- and A-type stars in binaries of larger separations hint at a much stronger effect of braking with age, we discuss the consequences of relaxing the constraints of the dynamical tides theory.
Metal-THINGS: a panchromatic analysis of the local scaling relationships of the dwarf irregular galaxy NGC 1569
Authors: Garduño L E , Zaragoza-Cardiel J , Lara-López M A , Zinchenko I A , Zerbo M C , De Rossi M E , Fritz Jacopo , Dib Sami , Pilyugin L S , Sánchez-Cruces M , Heesen V , O’Sullivan S P , López-Cruz O , Valerdi M , Rosado Margarita 
Published: September 2023

ABSTRACT
We investigate several panchromatic scaling relations (SRs) for the dwarf irregular galaxy NGC 1569 using Integral Field Unit (IFU) data from the Metal-THINGS Survey. Among the spatially resolved properties analysed, we explore SRs between the stellar mass, SFR, molecular gas, total gas, baryonic mass, gas metallicity, gas fraction, SFE, and effective oxygen yields. Such multiwavelength SRs are analysed at a spatial resolution of 180 pc, by combining our IFU observations with data from the surveys THINGS, CARMA, and archival data from DustPedia. Although we recover several known relations, our slopes are different to previously reported ones. Our star formation main sequence, Kennicutt–Schmidt (KS), and molecular KS relations show higher SFRs, lower scatter, and higher correlations, with steeper (1.21), and flatter slopes (0.96, 0.58), respectively. The shape of the SRs including metallicity, stellar mass, and gas fraction are flat, with an average value of 12 + log(O/H) ∼ 8.12 dex. The baryonic mass versus effective oxygen yields, and the stellar, gas and baryonic mass versus SFE show higher dispersions and lower correlations. Since we use the dust mass as a tracer of gas mass, we derive the dust-to-gas ratio and the CO luminosity-to-molecular gas mass conversion factors, showing differences of 0.16 and 0.95 dex for the total and molecular gas surface density, respectively, in comparison to previously reported values. We use a self-regulated feedback model to conclude that stellar feedback plays an important role generating outflows in NGC 1569.
The activity of 119 comets
Authors: Betzler Alberto S , Diepvens Alfons , de Sousa Orahcio F 
Published: September 2023

ABSTRACT
This study examines photometric data from 119 comets observed between 2011 and 2020 at the Olmen Observatory in Balen, Belgium, using R- and G-band filters. Applying the q-exponential distribution from Tsallis’ non-extensive mechanics, we find that our sample of short-period (SP) and long-period (LP) comets is complete for objects with an absolute magnitude of H0 ≤ 11.2 and ≤8.7, respectively. These magnitude constraints were used to perform a statistical analysis of the physical parameters describing these populations. LP comets generally have brighter absolute magnitudes and higher activity (median × 15.4) compared to SP comets. The secular light curves of these comets are symmetric about perihelion. Cometary activity was divided into four categories (‘unusual’, ‘typical’, ‘moderate’, and ‘strong’) based on the Afρ(0) parameter at perihelion, with about 72.7 and 53.6 per cent of the SP and LP comets falling into the ‘typical’ classification. The distribution of peak magnitudes ΔM for outbursts is similar for SP and LP comets, with a median value of −1.0 and a range of −0.2 to −2.90 mag. On average, there are 0.6 and 1.0 outbursts per comet for comets SP and LP, respectively. This result suggests that these events are somewhat more frequent for the LP comets. There is no evidence of periodicity in the frequency of outbursts based on our data. The peak magnitude ΔM of an outburst does not correlate with Afρ(0).
Stratospheric dayside-to-nightside circulation drives the 3D ozone distribution on synchronously rotating rocky exoplanets
Authors: Braam Marrick , Palmer Paul I , Decin Leen , Cohen Maureen , Mayne Nathan J 
Published: September 2023

ABSTRACT
Determining the habitability and interpreting future atmospheric observations of exoplanets requires understanding the atmospheric dynamics and chemistry from a 3D perspective. Previous studies have shown significant spatial variability in the ozone layer of synchronously rotating M-dwarf planets, assuming an Earth-like initial atmospheric composition. We simulate Proxima Centauri b in an 11.2-d orbit around its M-type host star using a 3D coupled climate-chemistry model to understand the spatial variability of ozone and identify the mechanism responsible for it. We document a previously unreported connection between the ozone production regions on the photochemically active dayside hemisphere and the nightside devoid of stellar radiation and thus photochemistry. We find that stratospheric dayside-to-nightside overturning circulation can advect ozone-rich air to the nightside. On the nightside, ozone-rich air subsides at the locations of two quasi-stationary Rossby gyres, resulting in an exchange between the stratosphere and troposphere and the accumulation of ozone at the gyre locations. The mechanism drives the ozone distribution for both the present atmospheric level (PAL) and a 0.01 PAL O2 atmosphere. We identify the hemispheric contrast in radiative heating and cooling as the main driver of the stratospheric dayside-to-nightside circulation. An age-of-air experiment shows that the mechanism also impacts other tracer species in the atmosphere (gaseous and non-gaseous phase) as long as chemical lifetimes exceed dynamical lifetimes. These findings, applicable to exoplanets in similar orbital configurations, illustrate the 3D nature of planetary atmospheres and the spatial and temporal variability that we can expect to impact spectroscopic observations of exoplanet atmospheres.
Non-LTE radio recombination line analysis towards H ii region G34.25+0.14
Authors: Wang Lixin , Wang Hongjun , Liu Bin , Armentrout Will 
Published: September 2023

ABSTRACT
The electron temperature $T^{*}_\mathrm{ e}$ of H ii regions in local thermodynamic equilibrium (LTE) is usually calculated based on the ratio of radio combination lines (RRLs) and continuum emission. In this work, the LTE $T^{*}_\mathrm{ e}$ in the H ii region G34.25+0.14, which is especially luminous and regarded as a prime target to investigate the physical properties of an H ii region, is obtained by analysing both RRLs and continuum in L band, and employing the correction factor $b_n^{*}$ to correct for non-LTE conditions. The LTE $T^{*}_\mathrm{ e}$ values in L band are calculated to be $2580\, {\rm K}$ for H i/OH/Recombination line survey (THOR) observations and $3690\, {\rm K}$ for Survey of Ionized Gas in our Galaxy, using the Arecibo telescope (SIGGMA), respectively. By employing a non-LTE correction, we derive Te of 8900 $\, {\rm K}$ and the corresponding $b^{*}_n$ values are calculated to be 1 and close to 1 in X band and C band, respectively. However, $b_n^{*}$ at L band (${\sim} 1.4\, {\rm GHz}$) is calculated as 4.2 and 2.4 for THOR and SIGGMA, suggesting that non-LTE corrections are necessary and significantly affect the results. This work demonstrates that the assumption of LTE to calculate $T^{*}_\mathrm{ e}$ is not valid for the observed transitions in L band, and hence, non-LTE corrections are needed. Furthermore, Ne for G34.25+0.14 is calculated from multiple bands independently, consistent with previous work. This study provides a method which could be used for other H ii regions to investigate their degree of departure from LTE.
Biases in velocity reconstruction: investigating the effects on growth rate and expansion measurements in the local universe
Authors: Turner Ryan J , Blake Chris 
Published: September 2023

ABSTRACT
The local galaxy peculiar velocity field can be reconstructed from the surrounding distribution of large-scale structure and plays an important role in calibrating cosmic growth and expansion measurements. In this paper, we investigate the effect of the stochasticity of these velocity reconstructions on the statistical and systematic errors in cosmological inferences. By introducing a simple statistical model between the measured and theoretical velocities, whose terms we calibrate from linear theory, we derive the bias in the model velocity. We then use lognormal realizations to explore the potential impact of this bias when using a cosmic flow model to measure the growth rate of structure, and to sharpen expansion rate measurements from host galaxies for gravitational wave standard sirens with electromagnetic counterparts. Although our illustrative study does not contain fully realistic observational effects, we demonstrate that in some scenarios these corrections are significant and result in a measurable improvement in determinations of the Hubble constant compared to standard forecasts.
PL01.4.A LATE BREAKING ABSTRACT: A LONG PEPTIDE VACCINE TARGETING THE CLONAL DRIVER MUTATION H3K27M IN ADULT PATIENTS WITH DIFFUSE MIDLINE GLIOMA
Authors: Grassl N , Poschke I , Lindner K , Kromer K , Bunse L , Mildenberger I , Jaehne K , Haltenhof G , Tan C , Green E , Kessler T , Suwala A , Sahm F , Eisele P , Breckwoldt M , Vajkoczy P , Grauer O , Herrlinger U , Tonn J , Denk M , Bendszus M , von Deimling A , Winkler F , Wick W , Lindner J , Platten M , Sahm K 
Published: September 2023

Abstract

BACKGROUND
Clonal and mutually exclusive substitution of lysine 27 to methionine in histone H3-3A (H3K27M) defines an aggressive subtype of diffuse glioma. These diffuse midline gliomas (DMG) are aggressive, incurable primary brain tumors that occur predominantly in a midline location in children and young adults. Surgical treatment options remain limited, response to chemoradiation is poor and palliative radiotherapy remains the only intervention with proven benefit, resulting in a median overall survival between 10 and 15 months after initial diagnosis. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses capable of controlling H3K27M+ tumors in a major histocompatibility complex (MHC)-humanized mouse model.

MATERIAL AND METHODS
Here we describe the first-in-human treatment with H3K27M-vac of eight adult patients with recurrent H3K27M+ DMG. Induction of mutation-specific immune responses was determined in peripheral blood using Interferon-γ ELISpot assays. Class II HLA-restricted peripheral H3K27M-specific T cells were expanded in vitro to characterize and track unique H3K27M-reactive T cell responses in blood and cerebrospinal fluid (CSF).

RESULTS
Repeat vaccinations with H3K27M-vac were safe and induced mutation-specific immune responses in five of eight patients after a median of two vaccinations. Median progression free survival after start of vaccination was 6.2 months and median overall survival was 12.8 months. In vitro restimulation of peripheral CD4+ and CD8+ T cells with H3 mutant peptide or wild type peptide revealed that H3K27M specific immune responses are CD4-mediated and can be suppressed by blocking antibodies against MHC II, but not MHC I. Furthermore, proximity ligation assay of formalin-fixed paraffin-embedded primary tumor tissue revealed that H3K27M neoepitope co-localizes with HLA class II-DR. One patient showed radiographic pseudoprogression (PsPD) according to iRANO criteria within six weeks after first detection of mutation-specific peripheral immune response. Following PsPD, three out of the top ten vaccine-induced, K27M-expanded CD4+ TCR clonotypes from peripheral blood were detectable in the CSF of this patient who went into sustained complete remission for &gt; 31 months.

CONCLUSION
H3K27M-vac is safe and induces H3K27M-specific CD4 T cell responses in patients with H3K27M+ DMG. An ongoing multicenter, phase 1 clinical trial for adult patients with newly diagnosed H3K27M+ DMG will assess the safety and immunogenicity of H3K27M-vac in combination with atezolizumab in standard-of-care radiotherapy (NCT04808245).