bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous transhepatic arterial access for coil embolization of hepatic artery infusion pump-associated bleeding
Authors: Dutta Anuj K. , Shankar Vishal , Santos Ernesto G. , Marinelli Brett , Alexander Erica S. , Sotirchos Vlasios S. , Zhao Ken 
Published: January 2025

Abstract
Background
Hepatic artery infusion pump (HAIP) chemotherapy is a locoregional treatment for intrahepatic malignancies. HAIPs are surgically implanted, and the catheter tip is typically inserted into a ligated gastroduodenal artery stump. Potential complications at the catheter insertion site include dehiscence, pseudoaneurysm or extravasation, and adjacent hepatic arterial stenosis and thrombosis. Bleeding complications can be treated with stent-graft placement or coil embolization across the injury site, typically with standard antegrade arterial approach into the hepatic arterial system by transfemoral or transradial access. However, in cases where an antegrade approach is not possible, alternative methods are necessary.

Case presentation
A patient presented with an enlarging hematoma due to bleeding at the gastroduodenal artery HAIP catheter insertion site. Emergent angiography revealed concomitant common hepatic artery occlusion and retrograde perfusion of the GDA via tortuous, diminutive hepatic collaterals which precluded standard antegrade approach. Collateral inflow from the dorsal pancreatic artery was utilized to opacify the right hepatic artery. The segment 5 hepatic artery was percutaneously accessed under fluoroscopic guidance, and microcoils were deployed both proximal and distal to origin of the gastroduodenal artery. The patient remained stable throughout the postoperative period and was discharged after an otherwise uneventful admission. Follow-up computed tomography demonstrated resolution of the hematoma and no bleeding or biliary complication from transhepatic access.

Conclusions
This report highlights the safety and efficacy of percutaneous transhepatic arterial access for endovascular management of HAIP associated bleeding at the gastroduodenal artery when standard antegrade interventions cannot be performed. Interventional radiologists caring for patients with HAIPs should be familiar with their potential complications and the range of techniques required for management.
Managing cotton canopy architecture for machine picking cotton via high plant density and plant growth retardants
Authors: Lakshmanan Sankar , Somasundaram Selvaraj , Shri Rangasami Silambiah , Anantharaju Pokkharu , Vijayalakshmi Dhashnamurthi , Ragavan Thiruvengadam , Dhamodharan Paramasivam 
Published: January 2025

AbstractMachine picking in cotton is an emerging practice in India, to solve the problems of labour shortages and production costs increasing. Cotton production has been declining in recent years; however, the high density planting system (HDPS) offers a viable method to enhance productivity by increasing plant populations per unit area, optimizing resource utilization, and facilitating machine picking. Cotton is an indeterminate plant that produce excessive vegetative growth in favorable soil fertility and moisture conditions, which posing challenges for efficient machine picking. To address this issue, the application of plant growth retardants (PGRs) is essential for controlling canopy architecture. PGRs reduce internode elongation, promote regulated branching, and increase plant compactness, making cotton plants better suited for machine picking. PGRs application also optimizes photosynthates distribution between vegetative and reproductive growth, resulting in higher yields and improved fibre quality. The integration of HDPS and PGRs applications results in an optimal plant architecture for improving machine picking efficiency. However, the success of this integration is determined by some factors, including cotton variety, environmental conditions, and geographical variations. These approaches not only address yield stagnation and labour shortages but also help to establish more effective and sustainable cotton farming practices, resulting in higher cotton productivity.
A comparative study of hybrid adaptive neuro-fuzzy inference systems to predict the unconfined compressive strength of rocks
Authors: Cao Wei 
Published: January 2025

AbstractThe accurate prediction of unconfined compressive strength (UCS) in rock samples is critical for the successful planning, design, and implementation of mining and civil engineering projects. UCS is crucial in assessing the stability and durability of rock masses, which directly influences the safety, efficiency, and cost-effectiveness of construction and excavation operations. Here’s a refined version of your text for enhanced clarity and flow: in this part, the execution of the proposed model was compared for both single and hybrid configurations. Hybrid models included support vector regression (SVR) combined with the Seahorse Optimizer (SVSH) and SVR combined with the COOT optimization algorithm (SVCO). For training, 70% of the UCS dataset was utilized, while the remaining 30% was equally divided between testing (15%) and validation (15%). For the model evaluation, several metrics were considered in this work, including the R2, RMSE, WAPE, MAE, and RAE, which ensure fairness in the analysis. The closer the R2 value comes to 1, the better the performance. The error metrics should be close to 0 for better accuracy. From Table 2, one can observe that the result of the standalone SVR model gave an RMSE of 6.213 during training and 9.454 during testing, hence showing poor performance. However, the inclusion of optimization algorithms significantly improved the performance of the SVR framework. Among the hybrid models, the SVSH model had the best performance, with an R2 value of 0.998 and an RMSE of 1.261 during training. The SVCO model performed moderately, with an R2 value of 0.988 during training.
High Prevalence of Malnutrition in Geriatric Patients With Solid Organ Cancer—An Institutional Study
Authors: Shriwastav Ujjawal Kumar , Sundriyal Deepak , Khanna Mridul , Sunny Neethu , Sehrawat Amit , Dhar Minakshi 
Published: January 2025

PURPOSE
The demographic transition toward aging heralds an increase in the number of geriatric patients with cancer in India. Comprehensive geriatric assessment (CGA) is a sine qua non for treatment planning and shared decision making in these patients. We aimed to study the prevalence of malnutrition and the associated risk factors in geriatric patients with solid organ cancer.

METHODS
In this observational study, treatment-naïve geriatric patients with cancer underwent CGA. We performed a Mini Nutritional Assessment (MNA) to diagnose malnutrition. Data analysis was done using descriptive statistics, Pearson’s chi-square, Spearman correlation, and multivariable regression analysis to assess the factors associated with malnutrition.

RESULTS

One hundred forty-two patients were included in the analysis. The median age was 67 (range, 60-88) years, with a male preponderance of 73.2% (n = 104) and a stage IV disease of 75.4% (n = 107). Most patients, 91.6% (n = 130), had abnormal MNA scores. Nearly one third of the patients, 35.2% (n = 50), were underweight (BMI <18.5 kg/m
2
). Poor performance status (PS) was seen in 66.2% (n = 94) of the patients. Poor appetite 79.6% (n = 113) was the most common risk factor, followed by addictions (74.6%, n = 106), chronic constipation (35.9%, n = 51), and polypharmacy (21.8%, n = 31). Cognitive impairment and depression were seen in 35.2% (n = 50) and 57.1% (n = 81) of the patients, respectively. The study found a significant correlation of MNA with age (
P
= .048), depression (
P
< .001), PS (
P
< .001), functional decline (
P
< .001), and cognition (
P
< .001).

CONCLUSION
There exists a widespread prevalence of malnutrition and amenable risk factors in geriatric patients with cancer. Nutritional assessment is essential, and interventions should be implemented to improve clinical outcomes.
Development of a genetically tailored implantation hepatocellular carcinoma model in Oncopigs by somatic cell CRISPR editing
Authors: Elkhadragy Lobna , Carlino Maximillian J. , Jordan Luke R. , Pennix Thomas , Ismail Nahed , Guzman Grace , Samuelson Jonathan P. , Schook Lawrence B. , Schachtschneider Kyle M. , Gaba Ron C. 
Published: January 2025

ABSTRACT
Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis, necessitating preclinical models for evaluating novel therapies. Large-animal models are particularly valuable for assessing locoregional therapies, which are widely employed across HCC stages. This study aimed to develop a large-animal HCC model with tailored tumor mutations. The Oncopig, a genetically engineered pig with inducible TP53R167H and KRASG12D, was used in the study. Hepatocytes were isolated from Oncopigs and exposed to Cre recombinase in vitro to create HCC cells, and additional mutations were introduced by CRISPR/Cas9 knockout of PTEN and CDKN2A. These edits increased Oncopig HCC cell proliferation and migration. Autologous HCC cells with these CRISPR edits were implanted into Oncopigs using two approaches: ultrasound-guided percutaneous liver injections, which resulted in the development of localized intrahepatic masses, and portal vein injections, which led to multifocal tumors that regressed over time. Tumors developed by both approaches harbored PTEN and CDKN2A knockout mutations. This study demonstrates the feasibility of developing genetically tailored HCC tumors in Oncopigs using somatic cell CRISPR editing and autologous implantation, providing a valuable large-animal model for in vivo therapeutic assessment.
Концепция благополучия в общественных науках
Authors: Аникин Василий Александрович , Нагерняк Мария Александровна , Воронина Наталья Дмитриевна 
Published: January 2025

В 2025 г. в издательстве «Прометей» под научной редакцией Л.Н. Овчаровой и В.А. Аникина выходит коллективная монография «Благополучие и развитие человеческого потенциала». Журнал «Мониторинг общественного мнения: экономические и социальные перемены» публикует сокращенную версию главы, посвященной подходам к концептуализации термина «благополучие» с опорой на существующие в российском и зарубежном полях теоретические и эмпирические наработки.
Интерес к теме благополучия в России растет не только со стороны научного сообщества, но и в публичном поле. В последние десятилетия заметно увеличилось число работ о субъективном благополучии, в том числе обзорного характера. Несмотря на это, в научной литературе отсутствует комплексный анализ концепта благополучия, включающий как его объективную, так и субъективную составляющие. Даже в обзорных работах сохраняется терминологическая неоднозначность из-за того, что ряд близких по смыслу понятий используются как синонимы к термину благополучие, а также из-за различий в отраслевой принадлежности авторов. Не претендуя на исключительность, авторы данной статьи предлагают междисциплинарную попытку обобщения и классификации путей концептуализации благополучия в общественных науках, а также систематизируют опыт российских ученых из разных отраслей знания. В работе предлагается рассматривать пять путей концептуализации: (1) благополучие в экономике благосостояния; (2) благополучие как удовлетворение потребностей, (3) благополучие как возможности, (4) когнитивные самооценки собственной жизни, (5) благополучие, рассматриваемое через аффективные оценки.
Благодарность. Материал подготовлен в рамках гранта, предоставленного Министерством науки и высшего образования Российской Федерации (№ соглашения о предоставлении гранта: 075-15-2022-325).
Авторы выражают глубокую благодарность Л.Н. Овчаровой за ценные комментарии на этапе предварительного обсуждения ключевых идей рукописи, участникам секции «Российское общество в «кризисное» десятилетие (к 10-летию социологического мониторинга ИС ФНИСЦ РАН)» в рамках Конференции «Cоциология: вчера, сегодня, завтра. К 50-летию журнала “Социологические исследования”» за обсуждение операционализации объективного благополучия, а также Н. Михайловой и С. Тер-Акопову за ценные идеи, высказанные в процессе подготовки рукописи.
Cell therapy for spinal cord contusion injury: evaluation of the efficacy of cryopreserved human umbilical cord blood mononuclear cells in a preclinical model
Authors: Ryabov S. I. , Zvyagintseva M. A. , Bazanovich S. A. , Morozova Ya. V. , Radaev S. M. , Zuev S. E. , Khvostova M. A. , Karanadze V. A. , Grin A. A. , Smirnov V. A. 
Published: January 2025

Objective. To evaluate the effect of systemic application of cryopreserved human umbilical cord blood mononuclear cells (hUCB-MNCs) in the acute period of spinal cord contusion injury (SCI) on the volume of zone of the spinal cord damage using high-field MRI.Material and Methods. This study was performed on adult female Sprague-Dowley rats. Severe contusion SCI was modeled using the weight-drop method. Cryopreserved hUCB-MNC concentrate, stored in a cryobank for 3–4 years at –196º°C, was administered intravenously 1 day after injury. Locomotor behavior was assessed when animals moved in an open field using the BBB (Basso – Beatty – Bresnahan) scale for rats. MRI examination of the spinal cord was performed using a Clin Scan 7.0 T device.Results. At week 6 after injury, a significant increase in the level of restoration of the motor function of the hind limbs (~10 %) was observed in the cell therapy group using hUCB-MNCs relative to the level of the self-healing group (p < 0.05). At the same time, the area of the posttraumatic cystic cavity decreased significantly (~45 %) and statistically significantly (p < 0.05), as well as its transverse (~38%) and longitudinal (~41 %) dimensions.Conclusion. Cryopreserved hUCB-MNCs may be an effective and affordable means of cell therapy for contusion SCI when used in the acute period of injury.
Novel Gain-of-Function Mutation in STAT-1 Protein with ALPS-like presentation
Authors: Ibrahim Bashair Mohammed , Alsalamah Mohammad 
Published: January 2025

Background: Germline mutations in STAT1 lead to primary immunodeficiency affecting both intrinsic and innate immunity. These immunodeficiencies can manifest as either loss-of-function (LOF) mutations or gain-of-function (GOF) mutations. LOF mutations result in a significant reduction in STAT1 protein functionality and are associated with Mendelian susceptibility to mycobacterial disease. Conversely, GOF mutations occur when a gene undergoes a change that enhances its normal function, resulting in an overactive form of the protein. Heterozygous STAT1 GOF mutations are the predominant cause of Chronic Mucocutaneous Candidiasis (CMC) in individuals with inborn errors of immunity. Aim: The study aims to report the clinical features, immune profile, and unique characteristics of a 9-year-old female patient with GOF mutations in STAT-1. Results: We present a case of an 8-year-old female who has been genetically diagnosed with a GOF mutation in the STAT 1 gene. The patient's clinical presentation includes lymphadenopathy, splenomegaly, the presence of non-caseating granulomas, and cytopenia. Notably, there is no evidence of mycobacterial infection typically associated with LOF mutation, nor any indication of fungal, viral, or malignant conditions. Furthermore, there are no signs of endocrine abnormalities such as thyroiditis or diabetes mellitus. The patient's immunological profile reveals evidence of autoimmunity, including symptoms of arthralgia and oral ulcers. Manual calculations of DN T cells showed no increase in their numbers. The patient did not exhibit typical signs of chronic mucocutaneous candidiasis (CMC) but presented with Autoimmune Lymphoproliferative Syndrome (ALPS)-like features, expanding the clinical spectrum of STAT1 GOF mutations. Discussion: The clinical and immunological characteristics of GOF mutations in STAT-1 vary considerably among case reports. The current case had no evidence of CMC, thus raising the possibility of ALPS-like syndrome as an extension of the commonly addressed features of GOF mutations. Statement of novelty: The absence of CMC in a patient with GOF mutations in STAT-1 is a rare presentation that should be considered when evaluating patients with inborn errors of immunity.
Exploring teacher-student interaction in task and non-task sequences
Authors: Zhu Yan , Newton Jonathan , Liu Yue , Shu Dingfang 
Published: January 2025

Abstract
In TBLT research, there is a noticeable lack of attention to the use of tasks with whole classes. This study seeks to address this gap by investigating the discourse of whole-class task-based teacher-student interaction compared to other types of teacher-student interaction in EFL classrooms in a primary school in China. A total of 223 pedagogic sequences from 16 EFL lessons taught by Chinese teachers to Grade 1 to 5 primary school student were recorded, transcribed, and coded as tasks or non-tasks using the four defining features of tasks proposed by Ellis and Shintani (2014. Exploring language pedagogy through second language acquisition research. London: Routledge). The analysis revealed that 95 sequences were task-based, 44 were non-task-based (i.e. they contained none of the four task features) and a further 84 sequences were also non-task-based but contained some but not all the four task features. In terms of the discourse features of task versus non-tasks sequences, task sequences had a higher ratio of teacher talk to student talk, a higher frequency of IRF exchanges, a lower frequency of teacher-class interaction, a lower frequency of teacher-initiated exchanges, a higher frequency of FoM exchanges and a lower frequency of FoFs exchanges, and a higher frequency of both display and referential questions. Overall, the findings provide process-oriented evidence for the distinctiveness of task-based teacher-student interaction.
A generalized version of Halanay inequality applied to a fractional nonlinear Hopfield neural network system
Authors: Kassim Mohammed D. , Al-Mahdi Adel M. , Othmani Sakina , Tatar Nasser-eddine 
Published: January 2025

Abstract
The standard Halanay inequality is generalized by considering fractional derivatives instead of first-order derivatives and also the nonlinear case. Moreover, we shall deal with a large class of kernels in distributed delays. It is then used to prove the Mittag-Leffler stability of a fractional nonlinear Hopfield neural network system with activation functions that are not necessarily Lipschitz continuous. The findings are supported by two explicit classes of admissible kernels and an example.
Analysis of PAPR reduction algorithms for optical OFDM 5G radio waveform system for visible light communication
Authors: Kumar Arun , Sarveswara Rao T.D.N.S.S , C.N. Gireesh Babu , Gaur Nishant , Nanthaamornphong Aziz 
Published: January 2025

Abstract
The integration of Optical Orthogonal Frequency Division Multiplexing (OFDM) with the 5G radio waveforms has lately been attracting special attention toward its possible Visible Light Communication (VLC) systems. On the other hand, however, a key challenge in the Optical OFDM is the presence of very high PAPR, degrading the overall system performance by introducing nonlinear distortions in the optical transmitter. In the present paper, different kinds of PAPR reduction algorithms specifically developed for Optical OFDM in VLC systems are developed and investigated. Analyze techniques like clipping, selective mapping (SLM), partial transmit sequence (PTS), and companding for their PAPR reduction efficiency along with the preservation of spectral efficiency and signal integrity. Based on the above aspects, various performance metrics, such as BER, computational complexity, and SNR, have been considered in order to understand each technique’s trade-off. It can be clearly seen that the hybrid and adaptive approaches achieve greater PAPR reduction without much loss of performance and are thus appropriate for future generation optical communication systems. This analysis underlines the use of optimized PAPR reduction algorithms to achieve robust and efficient systems for 5G VLC applications.
Coexistence of phenylketonuria and tyrosinemia type 3: challenges in the dietary management
Authors: Selamioğlu Arzu , Kozanoğlu Tuğba , Hacıoğlu İlknur , Balcı Mehmet Cihan , Karaca Meryem , Gedikbaşı Asuman , Uyanık Bülent , Gökçay Gülden 
Published: January 2025

Abstract

Objectives
Phenylketonuria (PKU) and tyrosinemia type 3 (HT3) are both rare autosomal recessive disorders of phenylalanine-tyrosine metabolism. PKU is caused by a deficiency in phenylalanine hydroxylase (PAH), leading to elevated phenylalanine (Phe) and reduced tyrosine (Tyr) levels. HT3, the rarest form of tyrosinemia, is due to a deficiency in 4-hydroxyphenylpyruvate dioxygenase (HPD).

Case presentation
We report a 5-year-old girl diagnosed with both PKU and HT3. She presented with elevated Phe levels in neonatal screening, and subsequent biochemical tests revealed both hyperphenylalaninemia and elevated Tyr levels. Genetic analysis confirmed the diagnoses, identifying homozygous mutations in both the PAH and HPD genes. Dietary management to maintain optimal Phe and Tyr levels proved to be challenging due to the presence of these two coexisting pathologies especially during infections and due to dietary non-compliance, necessitating frequent adjustments in the treatment strategy.

Conclusions
This case highlights the importance of considering multiple metabolic disorders in patients with unexplained clinical and biochemical findings. Early diagnosis and stringent dietary management are crucial for preventing neurological damage and ensuring favorable outcomes in patients with concurrent metabolic disorders.
Evaluating the challenges and opportunities for diabetes care policy in Nigeria
Authors: Olatunde Olalekan Isaac 
Published: January 2025

Abstract
Diabetes mellitus is a metabolic, non-communicable disease characterized by elevated blood glucose levels resulting from defects in insulin function, secretion, or both. Nigeria has a National Guideline on the Prevention, Control, and Management of Diabetes Mellitus. The guideline was developed in 2021 for healthcare practitioners and facilities to enhance their standard of care for diabetic patients, thereby enhancing the management and control of diabetes in Nigeria. Diabetes accounts for 1.52% of the total deaths in Nigeria. Given the high prevalence of diabetes in the country, there is a need for a national policy on diabetes care. This study evaluates the challenges associated with the formulation and implementation of a diabetes care policy in Nigeria. Identified challenges include inadequate funding of the healthcare system, insufficient human resources, poor health infrastructure, corruption, and low socioeconomic status. This study highlights and alerts policymakers to the challenges associated with diabetes, including its economic burden, the specific obstacles in formulating and implementing diabetes healthcare policy in Nigeria, and how this policy could help ameliorate the rising cases of diabetes in Nigeria. The study recommends that the government prioritize increased healthcare funding, human resource development, and infrastructure improvement while addressing corruption and implementing targeted interventions to improve socioeconomic conditions.