bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KETIDAKSESUAIAN ADMINISTRASI KEPABEANAN PADA FASILITAS KAWASAN BERIKAT TERHADAP KEGIATAN EKSPOR STUDI KASUS PT 888 WEST SEHATI
Authors: Rajendra Igo Maulanatazi  , Rohmawan Adi Pratama  , Islamiyah  
Published: September 2023

Perdagangan internasional menyebabkan seluruh negara di dunia semakin mudah terintegrasi antara satu negara dengan negara lainnya. Pemerintah Indonesia membuat kebijakan dengan memberikan fasilitas kawasan berikat yang merupakan fasilitas kepabeanan yang diberikan kepada para pelaku usaha yang produk utamanya berorientasi ekspor. Analisis ini bertujuan untuk mengetahui ketidaksesuaian penerapan administrasi kepabeanan di kawasan berikat terhadap kegiatan ekspor pada PT 888 West Sehati. Selain itu, penelitian juga akan membahas tentang pengaruh yang terjadi atas kasus ketidaksesuaian administrasi kepabeanan terhadap kegiatan ekspor. Metode yang digunakan dalam penelitian ini menggunakan analisis kualitatif di mana penelitian dilakukan dengan membaca dan memahami buku-buku referensi, jurnal, surat Keputusan, peraturan, dan undang-undang yang berdasarkan kepabeanan fasilitas kawasan berikat. Metode lain yang digunakan penulis adalah deskriptif yaitu mendeskripsikan fakta yang ditemukan selama penelitian untuk merumuskan strategi yang tepat bagi PT 888 West Sehati. Hasil dari penelitian ini yaitu pengaruh ketidaksesuaian administrasi kepabeanan fasilitas kawasan berikat terhadap kegiatan ekspor adalah perusahaan tidak dapat melakukan kegiatan ekspor dan tertahan oleh petugas bea cukai yang berakibat kerugian pada perusahaan. Saran yang diberikan untuk mengatasi ketidaksesuaian administrasi kepabeanan yaitu menerapkan proses tata laksana kepabeanan sesuai peraturan yang telah ditetapkan oleh Direktorat Jenderal Bea dan Cukai.
3D printed resin composite posterior fixed dental prosthesis: A prospective clinical trial up to 1 year
Authors: Ordueri Tugce , Hobbi Paniz , Öztürk-Bozkurt Funda , Toz-Akalın Tugba , Ateş Muzaffer , Özcan Mutlu 
Published: September 2023

Abstract
Objectives: This clinical trial evaluated the clinical behaviour of 3D printed posterior resin composite fixed dental prosthesis restorations.
Materials and Methods: Between 10.10.2020 - 05.08.2022, forty-nine patients aged between 19 and 60 years old (33 females, 16 males) received 68 3D printed resin composite 3-unit posterior fixed dental prosthesis (ELS Even Stronger, Saremco, Switzerland). FDPs were followed up 2 weeks after placement (baseline) by two independent calibrated observers using modified FDI criteria.
Results: Fifty-two FDPs completed their 6 months, 23 and 1of the resin composite FDPs their 1 and 2- year follow-up, respectively. Mean observation period was 8.63 months. Failure types were categorized as mechanical and biological ones. At the end of these observation periods, 8 FDPs showed cohesive fractures. Three abutment teeth needed endodontic treatment, 2 periodontal problems. One FDP was rebonded due to retention failure. After one year, 2 FDPs showed surface lusture loss (Score 4), 2 colour mismatch (Score 4), 2-surface staining (Score 4). Based on mechanical failures, survival rate was 86.7% while including the biological complications, this corresponded to 71.6% (Kaplan-Meier).
Conclusion: Long-term follow-up of the present cohort will indicate whether the tested material may serve as long-term provisional or even as permanent material for three-unit FDPs.
Clinical Relevance: Resin composite with improved properties could be preferred for permanent prosthetic applications rather than temporary approaches with current 3D technology and CAD / CAM applications.
Clinical Trial Registration Number: NCT04600297
Self-assembly and peripheral guest-binding of a sandwich-like complex [ZnII3L2]6+
Authors: Zhao Juan-Tong , Wu Wen-Yuan , Lou Yi-Chun , Cai Wei-Jie , Wan Rong 
Published: September 2023

Abstract
A novel complex [ZnII3L2]6+ was designed and then synthesized by using subcomponent self-assembly of zinc trifluoromethanesulfonate (Zn(OTf)2), 2,4,6-tri(3-aminophenoxy) triazine, and 2-formylpyridine in CH3CN solution. The target compound's structure as a sandwich-like helicate was verified by 1H NMR and ESI-MS measurements, and the host-guest interactions between the complex and a number of guest molecules were investigated. It was discovered that the effect of the host-guest interaction significantly changed when the aldehyde component was replaced by 3-methylpyridine-2-carboxaldehyde, which suggested that the guest-binding sites may occur around the peripheral apertures of the complex. Also the binding behavior of the tetraphenylborate guests was further investigated, which quantified the host-guest stoichiometry in the ratio of 1:2.
Polycystic intrahepatic infection caused by Enterococcus casseliflavus: A case report and literature review
Authors: Xu Senyin , Huang Bin , Cao Youjun , Zhong Zhongyong , Yin Jiazhen 
Published: September 2023

Abstract
Background: Enterococcus casseliflavus is a rare pathogenic bacterium that is characterized by vancomycin resistance and can lead to multiple infections in the human body. This report describes a rare case of polycystic intrahepatic infection with E. casseliflavus which necessitated antibiotic treatment and surgical intervention involving cystic drainage.
Case Presentation: A 59-year-old woman, a long-term hemodialysis patient, was hospitalized due to a 5-day history of fever, abdominal pain, and diarrhea, which were possibly caused by the ingestion of contaminated food. Her blood culture yielded a positive result for E. casseliflavus, and she was initially treated with piperacillin/tazobactam and linezolid. Later, the antibiotic regimen was adjusted to include meropenem and linezolid. Despite treatment, her body temperature remained elevated. However, subsequent blood cultures were negative for E.casseliflavus.Conventional CT scans and ultrasound examinations did not identify the source of infection. However, a PET-CT examination indicated an intrahepatic cyst infection. Following MRI and ultrasound localization, percutaneous intrahepatic puncture and drainage were performed on the 20th day. Fluoroquinolones were administered for 48 days. On the 32nd day, MRI revealed a separation within the infected cyst, leading to a repeat percutaneous drainage at a different site. Subsequently, the patient's temperature returned to normal. The infection was considered resolved, and she was discharged on the 62nd day. Follow-up results have been favorable thus far.
Conclusions: Based on the findings from this case, it is recommended to promptly conduct PET-CT examination to exclude the possibility of intracystic infection in cases of polycystic liver infection that are challenging to control. Furthermore, timely consideration should be given to puncture drainage in difficult cases.
On the convergence of uncertain set processes
Authors: Ghaffari-Hadigheh ‎Alireza , Vajargah Behrouz Fathi 
Published: September 2023

Abstract
Recently, the set-valued uncertain process has been introduced that is a sequence of uncertain sets evolving as time goes ahead. The concepts of convergence of set-valued uncertain processes were also defined from different points of view. Here, we elaborate on these definitions and investigate the relationship between them. We prove that some convergence concepts imply others while the inverse is not generally valid. We also propose a novel measure of convergence and verify its relationship with the others. Each finding is described with simple illustrative examples.
Quantitative Evaluation of a Quasi-Fermi Level of the Hole at a Photoanode/Electrolyte Interface
Authors: Takanabe Kazuhiro , Shioiri Yuu , Obata Keisuke , Kawase Yudai , Higashi Tomohiro , Katayama Masao 
Published: September 2023

Abstract
Valence band maximum (VBM) position does not necessarily indicate the driving force for oxidation reactions on photoanodes because it simply reflects an electrostatic potential. Rather, the quasi-Fermi level of the hole at the surface of photoanodes must be considered. Here, we report a protocol to quantitatively evaluate the quasi-Fermi level of the holes at the surface of photoanodes using redox species with various redox potentials. The quasi-Fermi level of these holes is estimated by correlating the photocurrent derived from redox species oxidation to the separately measured electrode potential on a stable model glassy carbon electrode. Using this protocol, the quasi-Fermi levels of holes on the surface of CdS and CdSe model photoanodes were found to be limited to merely 0.5 V vs. standard hydrogen electrode; this is fairly negative from the VBM position. The estimation of a quasi-Fermi level of the hole and the partial photocurrent density of the CdS and CdSe photocorrosion further enabled predictions of the photocorrosion kinetics. The predicted kinetics of the photocorrosion showed that the quasi-Fermi levels of hole at the surface of these photoanodes are pinned by the facile kinetics of the photocorrosion. This methodology offers a quantitative understanding of the oxidation capability of photoanodes.
Discrepant phenotyping of monocytes based on CX3CR1 using fluorescent reporters and antibodies
Authors: Sommer Katrin , Garibagaoglu Hilal , Wiendl Maximilian , Müller Tanja M. , Atreya Imke , Krönke Gerhard , Neurath Markus F. , Zundler Sebastian 
Published: September 2023

Abstract
Monocytes as well as downstream macrophages and dendritic cells are essential players of the immune system fulfilling key roles in homeostasis as well as in inflammatory conditions. Conventionally, driven by studies in reporter models, mouse monocytes are divided into a classical and a non-classical subset based on their inversely correlating surface expression of Ly6C and CX3CR1. Here, we analysed the expression of CX3CR1 by flow cytometry using several validated fluorochrome-coupled CX3CR1 antibodies and compared them with the reporter gene signal of a Cx3cr1GFP reporter mouse strain as well as of tamoxifen-inducible Cx3cr1 reporter mice. Although we were able to validate the specificity of several fluorochrome-coupled CX3CR1 flow cytometry antibodies, mouse Ly6Chigh classical and Ly6Clow non-classical monocytes showed no differences in CX3CR1 expression levels in peripheral blood and spleen, when stained with these antibodies. To the contrary, in reporter mice, we were able to reproduce the inverse correlation of CX3CR1 reporter gene signal and Ly6C surface expression. As determined by qPCR, the Cx3cr1 mRNA expression correlated with the GFP-reporter gene expression as quantified by flow cytometry. In conclusion, our data suggest that there is differential transcription, but not surface expression of CX3CR1 between classical and non-classical monocytes, which limits the suitability of CX3CR1 for phenotyping monocyte subsets by antibody staining.
A Rare Gene Mutation Disorder With Fever To Be Detected
Authors: Li Shanshan , Liu Na , Yu Jianmin , Tou Fangfang , Tong Bo 
Published: September 2023

Abstract
ROSAH syndrome(1) is an autosomal dominant disorder caused by mutations in ALPK1. Its clinical manifestations are mainly retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis and migraine. In this article, we aim to provide detailed information that will help further our understanding of the different symptoms and manifestations of ROSAH syndrome. It also emphasizes the importance of considering this disease in similar cases of fever of unknown etiology, such as recurrent periodic fever with splenomegaly and ocular disease.
Identification and Analysis of Hub Transcriptional Factors in vitro hepatocyte model of Acetaminophen- Induced Liver Injury
Authors: Zhao Qiang , Bai Jinjia , Zhao Ninghui , Yao Jia 
Published: September 2023

Abstract
Background
Acetaminophen-induced liver injury (AILI) is one of the most common causes of acute liver failure. It becomes more recognized that Transcription factors are involved in morphology alterations of hepatocyte in AILI patients. The integrated analysis of the Transcription factors role in the pathogenesis in AILI remains unknown.
Material and Methods
Based on bioinformatics, GEO databases and TF databases,we identify and analyze the hub TFs in vitro hepatocyte model of AILI and further evaluate the value of these TFs in the early diagnosis of AILI.
Results
A total of 97 AILI-related differentially expressed transcriptional factors (DETFs) were obtained, which were mainly enriched in the transcriptional activity, rhythmic process, cell fate commitment, liver development, and hepaticobiliary system development. Ten hub TFs (MYC, TP53, CEBPB, FOXM1, E2F1, EGR2, FOSL1, JUND, E2F7 and E2F8) were obtained from the PPI networks. In the early stage of AILI, qRT-PCR showed that the expressions level of MYC, TP53, CEBPB, E2F1, JUND, and E2F7 significantly changed compared with the control group (all P < 0.05), and these hub TFs had high sensitivity and specificity(all AUC ≥ 0.9); in contrast, the expressions level of FOXM1, EGR2, FOSL1 and E2F8 were not significantly different from those in the control group (all P＞0.05), and these hub TFs had certain sensitivity and specificity(all 0.67 ≤ AUC ≤ 0.79).
Rapid detection of Avian Influenza Virus based on CRISPR-Cas12a
Authors: Zhou Xu , Wang Siwen , Ma Yue , Li Yanbing , Deng Guohua , Shi Jianzhong , Wang Xiurong 
Published: September 2023

Abstract
Background: Avian influenza(AI) refers to the disease caused by infection with avian influenza viruses(AIV). These viruses naturally spread among wild aquatic birds worldwide and can infect domestic poultry, other birds, and animal species. At present, real-time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) is mainly used to detect the presence of pathogens, which has good sensitivity and specificity. However, the diagnosis requires sophisticated instruments under laboratory conditions, which significantly limits the point-of-care testing (POCT). A rapid, reliable, non-lab equipment reliant, sensitive, and specific diagnostic test is urgently needed in the field of clinical rapid detection and diagnosis.
Methods: In this study, Cas12a protein was purified using affinity chromatography with a Ni-Agarose resin and observed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The specific CRISPR-RNA (crRNA) and primers targeting the M and NP genes of AIV were designed and screened out. By combining reverse transcription recombinase polymerase amplification(RT-RPA) with the Cas12a/crRNA trans-cleavage system, the detection system through fluorescence readouts under blue light or using lateral flow strips was established. The sensitivity assays were carried out using a 10-fold dilution series of the plasmids and RNA of M and NP genes as the templates. The specificity of this method was determined by using H1~H16 subtypes AIVs and other avian pathogens such as Newcastle Disease Virus (NDV), Infectious Bursal Disease Virus (IBDV) and Infectious Bronchitis Virus (IBV).
Results:The results showed that the method was able to detect AIV and the detection limit can reach 6.7 copies/μL and 12 copies/μL for the M and NP gene, respectively. In addition, this assay showed no cross-reactivity with other avian-derived RNA viruses such as NDV, IBDV, and IBV. Moreover, the detection system presented 97.5% consistency and agreeability by comparing with the rRT-PCR and virus isolation in detecting samples from poultry. This portable and accurate method holds great application potential for detecting AIV in the field.
Conclusion: In summary, a RT-RPA/CRISPR method was developed for the rapid and sensitive detection of AIV. The new system presents a good potential to be an accurate, user-friendly, inexpensive platform for point-of-care testing applications.
Simultaneous analysis of the of levamisole with triclabendazole in pharmaceuticals through developing TLC and HPLC-PDA chromatographic techniques and their greenness assessment using GAPI and AGREE methods
Authors: Attia Khalid A.M. , El-Desouky Ebrahim A. , Abdelfatah Amr M. , Abdelshafi Nahla A. 
Published: September 2023

Abstract
Two simple and rapid chromatographic methods were developed and validated for the analysis of levamisole and triclabendazole simultaneously in pure and pharmaceutical products. The first method is thin-layer chromatography (TLC) with densitometry, and the second method is high-performance liquid chromatography with PDA detection (HPLC-PDA). A Hypersil BDS C18 column with dimensions of 4.6 x 150 mm and a particle size of 5 µm was used in the HPLC-PDA method. An isocratic condition was used to carry out the separation, and the mobile phase was made up of acetonitrile and a 0.03 M potassium dihydrogen phosphate buffer in double-distilled water. The ratio of the mobile phase preparation was 70:30 (v/v), and the flow rate was 1 mL/min. A wavelength of 215 nm was employed for analyte detection. Precoated silica gel 60 F254 aluminum plates were used for the TLC method's separation. Mobile phase was made of ethyl acetate, hexane, methanol, and ammonia (69:15:15:1) for the separation. The detection wavelength selected was 215 nm. According to the International Council for Harmonization (ICH) guidelines, the proposed methods were validated, and it was found that the two chromatographic methods are accurate, precise, and linear for both compounds in the range of 3.75–37.5 and 6–60 mg/L for the HPLC method for levamisole and triclabendazole, respectively and in the range of 2–14 µg/spot for the TLC method. The developed methods greenness profile was assessed using AGREE and ComplexGAPI tools.
Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings
Authors: Mays Gabriela Pierobon , Hett Kilian , Eisma Jarrod , McKnight Colin D. , Elenberger Jason , Song Alexander K. , Considine Ciaran , Han Caleb , Stark Adam , Claassen Daniel O. , Donahue Manus J. 
Published: September 2023

Abstract

BACKGROUND: Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation and accumulation of a-synuclein protofibrils. New diagnostic methods assess a-synuclein aggregation characteristics from cerebrospinal fluid and recent pathophysiologic mechanisms suggest that cerebrospinal fluid circulation disruptions may precipitate a-synuclein retention. Here, we test the hypothesis that cerebrospinal fluid motion at the level of the suprasellar cistern is reduced in Parkinson’s disease relative to healthy participants and this reduction relates to choroid plexus perfusion.
METHODS: Diffusion weighted imaging (spatial resolution=1.8x1.8x4 mm) magnetic resonance imaging with cycling of diffusion weightings (b-values=0, 50, 100, 200, 300, 700, and 1000 s/mm2) over the approximate kinetic range of suprasellar cistern neurofluid motion was applied at 3-Tesla in Parkinson’s disease (n=27; age=66±6.7 years) and healthy (n=32; age=68±8.9 years) participants. Wilcoxon rank-sum tests were applied to test the primary hypothesis that the decay rate of cerebrospinal fluid signal as a function of b-value, which reflects increasing fluid motion, is reduced in persons with versus without Parkinson’s disease and inversely relates to choroid plexus activity assessed from perfusion-weighted magnetic resonance imaging (Spearman rank-order correlation; significance-criteria: p<0.05).
RESULTS: Consistent with the primary hypothesis, decay rates were higher in healthy (D=0.00328±0.00123mm2/s) relative to Parkinson’s disease (D=0.00256±0.0094mm2/s) participants (p=0.016). This finding was preserved after controlling for age and sex. An inverse correlation between choroid plexus perfusion and decay rate (p=0.011) was observed in Parkinson’s disease participants.
CONCLUSIONS: Cerebrospinal fluid motion at the level of the suprasellar cistern is often reduced in adults with versus without Parkinson’s disease and this reduction correlates on average with choroid plexus perfusion.
Development and validation of a nomogram for predicting in-hospital mortality in patients with nonhip femoral fractures
Authors: XING ZHIbin , WU YUxuan , XU YIwen , FU XIAOchen , SHEN PENGfei , WANG JING 
Published: September 2023

Abstract
Background The incidence of nonhip femoral fractures is gradually increasing, but no studies have explored the risk factors for in-hospital death in patients with nonhip femoral fractures in the ICU or developed mortality prediction models. Therefore, we chose to study this specific patient group, hoping to help clinicians improve the prognosis of patients.Methods The ROC curve was drawn, and the AUC, NRI and IDI were calculated to evaluate the discrimination of the model. The consistency between the actual probability and the predicted probability was assessed by the calibration curve and HL test. DCA was performed, and the nomogram was compared with the scoring system commonly used in clinical practice to evaluate the clinical net benefit.Results The least absolute shrinkage and selection operator (LASSO) regression analysis showed that heart rate, temperature, red blood cell distribution width, blood urea nitrogen, GCS, SA PSII, Charlson comorbidity index and cerebrovascular disease were independent risk factors for in-hospital death in patients with nonhip femoral fractures. The areas under the curve (AUC), integrated discrimination improvement (IDI) and net reclassification index (NRI) of our model in the training set and validation set were better than those of the GCS and SAPSII scoring systems. The calibration curve and HL test results showed that our model prediction results were in good agreement with the actual results (P = 0.833 for the HL test of the training set and P = 0.767 for the HL test of the validation set). Decision curve analysis (DCA) showed that our model had a better clinical net benefit than the GCS and SAPSII scoring systems..Conclusion In this study, the independent risk factors for in-hospital death in patients with nonhip femoral fractures were determined, and a prediction model was constructed. The results of this study may help to improve the clinical prognosis of patients with nonhip femoral fractures.
Network Pharmacology and Molecular Docking-based Investigation of Monocyte Locomotion Inhibitory Factor Attenuates Traumatic Brain Injury by Regulating Aquaporin 4 Expression
Authors: Li Xinyu , Ma Yulin , Lv Mengting , Gao Yuan , Zhang Yuefan , Li Tiejun 
Published: September 2023

Abstract
Traumatic brain injury (TBI) is a significant cause of disability and mortality worldwide, and effective treatment options are currently limited. Monocyte locomotion inhibitor factor (MLIF), a small molecular pentapeptide, has demonstrated a protective effect against cerebral ischemia. This study aimed to investigate the protective effects of MLIF on TBI and explore its underlying mechanism of action. In animal experiments, we observed that administration of MLIF after TBI reduced brain water content and improved brain edema, suggesting a certain degree of protection against TBI. By utilizing of network pharmacology methodologies, we employed target screening techniques to identify the potential targets of MLIF in the context of TBI. As a result, we successfully enriched 10 signaling pathways that are closely associated with TBI. Furthermore, using molecular docking techniques, we identified AQP4 as one of the top 10 central genes discovered in this study. Eventually, our study demonstrated that MLIF exhibits anti-apoptotic properties and suppresses the expression of AQP4 protein, thus playing a protective role in traumatic brain injury. This conclusion was supported by TUNEL staining and the evaluation of Bcl-2, Bax, and AQP4 protein levels. These discoveries enhance our comprehension of the mechanisms by which MLIF exerts its protective effects and highlight its potential as a promising therapeutic intervention for TBI treatment.