bluuebunny/crossref_metadata_2025_split huggingface dataset:
Step‐back anterior repositioning splint retraction for temporomandibular joint disc displacement with reduction in adult patients
Authors: Li Hui , Shen Da , Chen Zhihong , Li Jian 
Published: May 2023

AbstractBackgroundAnterior repositioning splint (ARS) is used to treat temporomandibular joint (TMJ) disc displacement with reduction (DDwR). However, high recurrence rate remains a problem especially in patients with unstable occlusions.ObjectiveThis study optimised standard ARS therapy and proposed a step‐back ARS retraction (SAR) method in adult patients with DDwR.MethodsDental examinations and magnetic resonance imaging of TMJ were obtained before treatment (T0), 1 to 3 months (T1), 3 to 6 months (T2) and 6 to 12 months (T3) during treatment in 48 adults (average age 27.1 ± 5.7 years). After 3 months of basic ARS wearing, personalised treatment for patients with normal disc–condyle relationship was prescribed depending on bilaminar zone adaptations and severity of molar openbite. SAR which required sequential ARS wearing was designed for patients with deep overbite/overjet until retrodiscal tissue adaptations and stable occlusions were achieved.ResultsThe maximum interincisal opening was increased from 44.3 ± 6.9 to 45.3 ± 6.3 mm (p < .01), and joint pain was alleviated after ARS treatment. The overall success rate of ARS wearing was 92.1% (58/63) featured by a recaptured disc. Fifteen patients who underwent SAR therapy all showed bilaminar zone adaptations in the end, and one patient had positive condylar bone remodelling.ConclusionsARS treatment could improve mouth opening and joint symptoms in adult DDwR patients. SAR method was suitable for treating DDwR patients with deep overbite and overjet and improved retrodiscal tissue adaptations and condylar bone remodelling.
Impact of the COVID‐19 Pandemic on Religiosity: Evidence from Germany
Authors: Kanol Eylem , Michalowski Ines 
Published: May 2023

AbstractHow does a major external shock that potentially threatens the community and the individual impact religiosity in the context of ongoing secularization? Do individuals in a rich and secularized society such as Germany react to potential community‐level (sociotropic) and individual‐level (egotropic) threat with heightened religiosity? We estimate multilevel regression models to investigate the impact of sociotropic and egotropic existential security threats associated with the COVID‐19 pandemic on individuals’ religiosity. Our data come from a rolling cross‐sectional online survey conducted in Germany among 7,500 respondents across 13 waves in 2020. Our findings suggest that a global health pandemic such as COVID‐19 increases individuals’ perception of existential and economic threat, which, in turn, leads to an increase in religiosity. However, this relationship is only true for egotropic existential security threat but not for sociotropic threat. We discuss the theoretical implications of these findings.
Feral American mink Neogale vison continues to expand its European range: time to harmonise population monitoring and coordinate control
Authors: Vada Rachele , Illanas Sonia , Acevedo Pelayo , Adriaens Tim , Apollonio Marco , Belova Olgirda , Blanco‐Aguiar Jose Antonio , Csányi Sándor , Body Guillaume , Fernández‐De‐Mera Isabel G. , Ferroglio Ezio , Jansen Patrick A. , Jeschke Jonathan M. , Keuling Oliver , Palazón Santiago , Plis Kamila , Podgórski Tomasz , Rickowski Fiona , Scandura Massimo , Shakun Vasilij , Smith Graham C. , Stephens Philip A. , Van Den Berge Koen , Veeroja Rauno , Zanet Stefania , Zihmanis Ilgvars , Vicente Joaquin 
Published: May 2023

Abstract

The American mink Neogale vison is an invasive alien species in Europe that threatens endemic biodiversity and can transmit zoonotic diseases, including the SARS‐CoV‐2 virus. The last attempt to map the geographic range of this species in Europe, at continental scale, dates back to 2007.

We aimed to update the distribution map of the feral American mink and assess its temporal trends. The information we collected was critically analysed with the aim of improving future monitoring protocols and data collection.

We gathered and standardised data from 34 databases, covering 32 countries. Through 3 five‐year periods from 2007 to 2021, changes in range size, hunting bags and capture statistics were analysed. We also reviewed the current situation of mink farming in the different European countries and recorded population control schemes.

The American mink is now widespread in the Baltic States, France, Germany, Iceland, Ireland, Poland, Scandinavia, Spain and the UK. The species is reported to be absent in some areas (e.g. parts of the UK, Iceland and Norway). Data are deficient for several countries, mainly in south‐eastern Europe. These findings indicate that, during the last 15 years, the species has continued to spread across the continent, increasing its potential extent of occurrence in most countries. Our effort to collect and harmonise data across international borders highlighted information gaps and heterogeneity in data quality.

Updated distribution data on the species provided here will aid risk assessment and risk management policies. These actions require a coordinated effort for population monitoring at continental level. Monitoring effort and data collection should be intensified in south‐eastern Europe to improve data on the current distribution of this invasive species.
The involvement of CdhR in Porphyromonas gingivalis during nitric oxide stress
Authors: Boutrin Marie‐Claire , Mishra Arunima , Wang Charles , Dou Yuetan , Fletcher Hansel M. 
Published: May 2023

AbstractPorphyromonas gingivalis, the causative agent of adult periodontitis, must gain resistance to frequent oxidative and nitric oxide (NO) stress attacks from immune cells in the periodontal pocket to survive. Previously, we found that, in the wild‐type and under NO stress, the expression of PG1237 (CdhR), the gene encoding for a putative LuxR transcriptional regulator previously called community development and hemin regulator (CdhR), was upregulated 7.7‐fold, and its adjacent gene PG1236 11.9‐fold. Isogenic mutants P. gingivalis FLL457 (ΔCdhR::ermF), FLL458 (ΔPG1236::ermF), and FLL459 (ΔPG1236‐CdhR::ermF) were made by allelic exchange mutagenesis to determine the involvement of these genes in P. gingivalis W83 NO stress resistance. The mutants were black pigmented and β hemolytic and their gingipain activities varied with strains. FLL457 and FLL459 mutants were more sensitive to NO compared to the wild type, and complementation restored NO sensitivity to that of the wild type. DNA microarray analysis of FLL457 showed that approximately 2% of the genes were upregulated and over 1% of the genes downregulated under NO stress conditions compared to the wild type. Transcriptome analysis of FLL458 and FLL459 under NO stress showed differences in their modulation patterns. Some similarities were also noticed between all mutants. The PG1236‐CdhR gene cluster revealed increased expression under NO stress and may be part of the same transcriptional unit. Recombinant CdhR showed binding activity to the predicted promoter regions of PG1459 and PG0495. Taken together, the data indicate that CdhR may play a role in NO stress resistance and be involved in a regulatory network in P. gingivalis.
The integration of reactive oxygen species (ROS) and calcium signalling in abiotic stress responses
Authors: Ravi Barkha , Foyer Christine H. , Pandey Girdhar K. 
Published: May 2023

AbstractReactive oxygen species (ROS) and calcium (Ca2+) signalling are interconnected in the perception and transmission of environmental signals that control plant growth, development and defence. The concept that systemically propagating Ca2+ and ROS waves function together with electric signals in directional cell‐to‐cell systemic signalling and even plant‐to‐plant communication, is now firmly imbedded in the literature. However, relatively few mechanistic details are available regarding the management of ROS and Ca2+ signals at the molecular level, or how synchronous and independent signalling might be achieved in different cellular compartments. This review discusses the proteins that may serve as nodes or connecting bridges between the different pathways during abiotic stress responses, highlighting the crosstalk between ROS and Ca2+ pathways in cell signalling. We consider putative molecular switches that connect these signalling pathways and the molecular machinery that achieves the synergistic operation of ROS and Ca2+ signals.
Pancreatic acinar cell carcinoma with pleomorphic and spindle cells: An autopsy‐proven case
Authors: Uruga Hironori , Tamura Tetsuo , Miura Yasuro , Itonaga Jumpei , Koyama Rikako , Imamura Tsunao , Takazawa Yutaka 
Published: May 2023

AbstractPancreatic acinar cell carcinomas are glandular and have amphophilic/eosinophilic cytoplasm, presenting acinar, solid, and trabecular structures. Unusual histological features of acinar cell carcinoma are known, such as oncocytic, pleomorphic, spindle, and clear cell variants, but their clinical significance has not been well described. A man in his 70s was referred to our hospital because of elevated serum pancreatic enzymes. Contrast‐enhanced abdominal computed tomography revealed slight swelling of the pancreatic head and suspension of the main pancreatic duct in the pancreatic body. He died only 14 days after admission. Gross findings at autopsy showed an ill‐defined tumor located in the pancreatic head, involving the gastric and duodenal walls. Peritoneal dissemination, liver metastases, and lymph node metastases were also observed. Microscopically, tumor cells had moderate‐to‐severe nuclear atypia and amphophilic cytoplasm showing pleomorphism, and diffusely proliferated in solid pattern without lumina, were admixed with spindle cells. Immunohistochemically, tumor cells including pleomorphic and spindle cells were positive for B‐cell lymphoma/leukemia 10 and trypsin. Consequently, the diagnosis was pancreatic acinar cell carcinoma with pleomorphic and spindle cells. We encountered a rare variant of pancreatic acinar cell carcinoma with pleomorphic and spindle cells. Clinically, our case showed rapid progression.
ADAM metallopeptidase with thrombospondin type 1 motif 16 is a potential marker for prognosis in clear cell renal cell carcinoma
Authors: Bai Chen , Chen Deng‐gang 
Published: May 2023

AbstractThe mortality rate of clear cell renal cell carcinoma (ccRCC) remains high. Immunohistochemical staining, Western blotting and real‐time quantitative polymerase chain reaction were employed to evaluate ADAM (a disintegrin and metalloproteinase) metallopeptidase with thrombospondin type 1 motif 16 (ADAMTS16) levels in ccRCC tissues and paired normal tissues, and all tissues were obtained from clinical samples of 46 cases of ccRCC patients. Moreover, we analyzed the role ADAMTS16 in the progression of ccRCC using Cell Counting Kit‐8 assay and flow cytometry. ADAMTS16 levels in ccRCC tissues were markedly low, relative to normal tissues, and ADAMTS16 level closely correlated with tumor stage, lymph node metastasis as well as pathological grade. Patients with elevated ADAMTS16 expressions have a more favorable survival outcome, relative to patients with low expression of ADAMTS16. In vitro study showed ADAMTS16 expression markedly decreased in ccRCC cells and acted as a tumor suppressor compared with the normal cells. The expression of ADAMTS16 is down‐regulated in ccRCC tissues, relative to normal tissues, and it may inhibit the malignancies of ccRCC. Such inhibitory effect may be ascribed to the involvement of AKT/mammalian target of rapamycin signaling. Hence, the present study of ADAMTS16 will provide new insight into the underlying biological mechanisms of ccRCC.
How the initial discovery of modified RNA enabled evasion of innate immune responses and facilitated the development of RNA therapeutics
Authors: Sioud Mouldy 
Published: May 2023

AbstractBesides being the physical link between DNA and proteins, RNAs play several other key roles, including RNA catalysis and gene regulation. Recent advances in the design of lipid nanoparticles have facilitated the development of RNA‐based therapeutics. However, chemically and in vitro transcribed RNAs can activate innate immunity, leading to the production of proinflammatory cytokines and interferons, a response similar to the one induced by viral infections. Since these responses are undesirable for certain therapeutic applications, it is important to develop ways to block the sensing of exogenous RNAs by immune cells, such as monocytes, macrophages and dendritic cells. Fortunately, RNA sensing can be blocked by chemical modifications of certain nucleotides, particularly uridine, a finding that has facilitated the development of RNA‐based therapeutics such as small interfering RNAs and mRNA vaccines. Here, I provide a backstory on how improved understanding of RNA sensing by innate immunity can be applied to develop more effective RNA therapeutics.
OsCBL5–CIPK1–PP23 module enhances rice grain size and weight through the gibberellin pathway
Authors: Zhang Yachun , Gan Lu , Zhang Yujie , Huang Baosheng , Wan Binliang , Li Jinbo , Tong Liqi , Zhou Xue , Wei Zhisong , Li Yan , Song Zhaojian , Zhang Xianhua , Cai Detian , He Yuchi 
Published: May 2023

SUMMARYGrain size is a key factor in determining rice (Oryza sativa) yield, and exploring new pathways to regulate grain size has immense potential to improve yield. In this study, we report that OsCBL5 encodes a calcineurin B subunit protein that significantly promotes grain size and weight. oscbl5 plants produced obviously smaller and lighter seeds. We further revealed that OsCBL5 promotes grain size by affecting cell expansion in the spikelet hull. Biochemical analyses demonstrated that CBL5 interacts with CIPK1 and PP23. Furthermore, double and triple mutations were induced using CRISPR/Cas9 (cr) to analyze the genetic relationship. It was found that the cr‐cbl5/cipk1 phenotype was similar to that of cr‐cipk1 and that the cr‐cbl5/pp23, cr‐cipk1/pp23, and cr‐cbl5/cipk1/pp23 phenotype was similar to that of cr‐pp23, indicating that OsCBL5, CIPK1, and PP23 act as a molecular module influencing seed size. In addition, the results show that both CBL5 and CIPK1 are involved in the gibberellic acid (GA) pathway and significantly affect the accumulation of endogenous active GA4. PP23 participates in GA signal transduction. In brief, this study identified a new module that affects rice grain size, OsCBL5–CIPK1–PP23, which could potentially be targeted to improve rice yield.
Quantum Borcherds–Bozec algebras via semi‐derived Ringel–Hall algebras II: Braid group actions
Authors: Lin Ji , Lu Ming , Ruan Shiquan 
Published: May 2023

AbstractBased on the realization of quantum Borcherds–Bozec algebra and quantum‐generalized Kac–Moody algebra via semi‐derived Ringel–Hall algebra of a quiver with loops, we deduce the braid group actions of introduced by Fan and Tong recently and establish braid group actions for by applying the Bernstein‐Gelfand‐Ponomarev (BGP)‐reflection functors to semi‐derived Ringel–Hall algebras.
Koecher–Maass series have infinitely many critical zeros
Authors: Meher Jaban , Pandey Manish Kumar , Shankhadhar Karam Deo 
Published: May 2023

AbstractIn this article, we prove the infinitude of the non‐trivial zeroes of Koecher–Maass series associated to a Siegel cusp form of weight and degree 2 on the critical line.
Dual Function Matrix Projective Synchronization for Fractional-Order Hyperchaotic Systems
Authors: He Jinman , Pei Lijun 
Published: May 2023

Abstract
It is well known that the variability and complexity of projection proportionality factors of dual projective synchronization (DPS) can effectively enhance signal confidentiality. However, in most literatures, the proportionality factors are some simple fixed constants, which can't ensure high security of information. For two pairs of fractional-order hyperchaotic systems (FOHS), how to expand the projection proportionality factors to increase its complexity? Then, our work will propose a new synchronization type, i.e., Dual Function Matrix Projective Synchronization (DFMPS) and realize the DFMPS for FOHS for the first time. Firstly, based on the traditional DPS, we generalize the proportionality factors to a function matrix depending on time t, present the error functions and define the DFMPS. Then, for FOHS, the active controller and synchronization condition are designed and proved. At the same time, when the system is affected by parameter disturbances, the active controller can eliminate the influence of parameter disturbances to the system's DFMPS, which indicates that the proposed control strategy has strong robustness. Finally, the DFMPS of two pairs of fractional-order hyperchaotic Chen and Rabinovich systems are realized, and synchronizing analysis and system robustness analysis are verified by numerical simulation. Particularly, the DFMPS can be degenerated to dual antisynchronization, dual complete synchronization, DPS, modified DPS and dual matrix projective synchronization. This work extends the synchronization types for FOHS and offers a useful method to explore DFMPS for other fractional-order systems.
Exploring the Intersection of Metaverse, Digital Twins, and Artificial Intelligence in Training and Maintenance
Authors: Bordegoni Monica , Ferrise Francesco 
Published: May 2023

Abstract
As technology advances, we are surrounded by more complex products that can be challenging to use and troubleshoot. We often turn to online resources and the help of others to learn how to use a product’s features or fix malfunctions. This is a common issue in both everyday life and industry. The key to being able to use a product or fix malfunctions is having access to accurate information and instructions and gaining the necessary skills to perform the tasks correctly. This paper offers an overview of how artificial intelligence, digital twins, and the metaverse—currently popular technologies—can enhance the process of acquiring knowledge, know-how, and skills, with a focus on industrial maintenance. However, the concepts discussed may also apply to the maintenance of consumer products.
Harnessing Multi-Domain Knowledge for User-Centric Product Conceptual Design
Authors: Guo Xin , Huang Zechuan , Liu Ying , Zhao Wu , Yu Zeyuan 
Published: May 2023

Abstract
Conceptual design is the design phase that deploys product functions and structures based on user requirements and ultimately generates conceptual design solutions. The increasing diversification of products has led to the promotion of customized design that involves deep user participation. As a result, there has been a growing focus on user-centric conceptual design. In this regard, the relationship among users, designers, and design solutions has been changed, which has brought challenges to the traditional designer-oriented design model. To address the complex understanding and decision-making problem caused by deeper user participation, emerging new user-centric product conceptual design model needs to be discussed. In the new design model, addressing the changing or growing requirements of users through the design of solutions and leveraging multi-domain knowledge to guide the conceptual design process are the critical areas of focus. To further describe this design model, this paper examines the user-centric interconnection among users, designers, design solutions, and multi-domain knowledge. In order to optimize design solutions, the solution resolution process and knowledge mapping based on design deviations are considered effective approaches. In addition, the paper also presents the types of design deviations and the multi-domain knowledge support techniques.
Design of Position Estimator for Rope Driven Micromanipulator of Surgical Robot Based on Parameter Autonomous Selection Model
Authors: Wang Wenjie , Wang Jie , Chen Congcong , Luo Yang , Wang Xiaohua , Yu Lingtao 
Published: May 2023

AbstractAs the micromanipulator of surgical robots works in a narrow space, it is difficult to install any position sensors at the end, so the position control and position detection cannot be accurately performed. A position estimator based on the parameter autonomous selection model is proposed to estimate the end position indirectly. First, a single joint principle prototype and a position estimator model are established through the 4DOF driving scheme of the micromanipulator and the cable-driven model. Second, the proposed parameter change model is combined with the parameter selection method to form a parameter autonomous selection model. Finally, a position estimator based on the parameter autonomous selection model is established. The experimental results show the maximum estimation error of the position estimator is 0.1928 deg. Compared with other position estimation methods, the position estimator proposed in this paper has higher accuracy and better robustness, which lays a foundation for the full closed-loop control of micromanipulator position.
Kinematic Modeling and Open-Loop Control of a Twisted String Actuator-Driven Soft Robotic Manipulator
Authors: Konda Revanth , Bombara David , Chow Ember , Zhang Jun 
Published: May 2023

Abstract
Realizing high-performance soft robots is challenging because many existing soft or compliant actuators exhibit limitations like fabrication complexity, high power requirement, slow actuation, and low force generation. Due to their high-force output and power efficiency, compactness, and simplicity in fabrication, twisted string actuators (TSAs) have exhibited strong potential in mechatronic and robotic applications. However, they have had limited uses in soft robotics. Consequently, modeling and control of TSA-driven soft robots have not been sufficiently studied. This article presents the first study on the modeling and control of a TSA-driven soft robotic manipulator. A physics-based model was developed to predict the manipulator’s kinematic motion. An inverse model was derived to realize open-loop control. Models that describe the behavior of TSAs were utilized in a novel way to develop the proposed kinematic and inverse models of the soft robot. The proposed modeling and control approaches were experimentally verified to be effective. For example, the modeling and control errors of the bending angle were 1.60 deg (3.11%) and 2.11 deg (3.68%), respectively.