bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximation hierarchies for copositive cone over symmetric cone and their comparison
Authors: Nishijima Mitsuhiro , Nakata Kazuhide 
Published: August 2023

AbstractWe first provide an inner-approximation hierarchy described by a sum-of-squares (SOS) constraint for the copositive (COP) cone over a general symmetric cone. The hierarchy is a generalization of that proposed by Parrilo (Structured semidefinite programs and semialgebraic geometry methods in Robustness and optimization, Ph.D. Thesis, California Institute of Technology, Pasadena, CA, 2000) for the usual COP cone (over a nonnegative orthant). We also discuss its dual. Second, we characterize the COP cone over a symmetric cone using the usual COP cone. By replacing the usual COP cone appearing in this characterization with the inner- or outer-approximation hierarchy provided by de Klerk and Pasechnik (SIAM J Optim 12(4):875–892, https://doi.org/10.1137/S1052623401383248, 2002) or Yıldırım (Optim Methods Softw 27(1):155–173, https://doi.org/10.1080/10556788.2010.540014, 2012), we obtain an inner- or outer-approximation hierarchy described by semidefinite but not by SOS constraints for the COP matrix cone over the direct product of a nonnegative orthant and a second-order cone. We then compare them with the existing hierarchies provided by Zuluaga et al. (SIAM J Optim 16(4):1076–1091, https://doi.org/10.1137/03060151X, 2006) and Lasserre (Math Program 144:265–276, https://doi.org/10.1007/s10107-013-0632-5, 2014). Theoretical and numerical examinations imply that we can numerically increase a depth parameter, which determines an approximation accuracy, in the approximation hierarchies derived from de Klerk and Pasechnik (SIAM J Optim 12(4):875–892, https://doi.org/10.1137/S1052623401383248, 2002) and Yıldırım (Optim Methods Softw 27(1):155–173, https://doi.org/10.1080/10556788.2010.540014, 2012), particularly when the nonnegative orthant is small. In such a case, the approximation hierarchy derived from Yıldırım (Optim Methods Softw 27(1):155–173, https://doi.org/10.1080/10556788.2010.540014, 2012) can yield nearly optimal values numerically. Combining the proposed approximation hierarchies with existing ones, we can evaluate the optimal value of COP programming problems more accurately and efficiently.
Aliasing Effect on Flux Ramp Demodulation: Nonlinearity in the Microwave Squid Multiplexer
Authors: Salum J. M. , Muscheid T. , Fuster A. , Garcia Redondo M. E. , Hampel M. R. , Ferreyro L. P. , Geria J. M. , Bonilla-Neira J. , Müller N. , Bonaparte J. , Almela A. , Ardila-Perez L. E. , Platino M. , Sander O. , Weber M. 
Published: August 2023

AbstractA novel system formed by a Microwave Superconducting Quantum Interference Device (SQUID) Multiplexer ($$\mu$$
μ
MUX) and a room temperature electronics employs frequency division multiplexing (FDM) technique to read out multiple cryogenic detectors. Since the detector signal is embedded in the phase of the SQUID signal, a Digital Quadrature Demodulator (DQD) is widely implemented to recover it. However, the DQD also generates a signal that aliases into the first Nyquist zone affecting the demodulated detector signal. In this work, we demonstrate how this spurious signal is generated and a mathematical model of it is derived and validated. In addition, we discuss different proposals to improve the attenuation of this undesired signal. Lastly, we implement one of the proposals in our readout system. Our measurements show an enhancement in the spurious signal attenuation of more than 35 dB. As a result, this work contributes to attenuate the spurious below the system noise.
Development and Characterization of New Environmentally Friendly Polylactide Formulations with Terpenoid-Based Plasticizers with Improved Ductility
Authors: Gomez-Caturla J. , Tejada-Oliveros R. , Ivorra-Martinez J. , Garcia-Sanoguera D. , Balart R. , Garcia-Garcia D. 
Published: August 2023

AbstractThis work addresses the potential of two biobased terpenoids, linalyl acetate and geranyl acetate, as environmentally friendly monomeric plasticizers for polylactide (PLA). Plasticized formulations of PLA containing 10 wt.% and 20 wt.% terpenoids were melt-compounded in a twin-screw co-rotating extruder and, subsequently, processed by injection moulding for further characterization. In addition, a reactive extrusion process (REX) was carried out on plasticized formulations containing 20 wt.% terpenoids with dicumyl peroxide to anchor the plasticizer molecules into the PLA backbone. Both terpenoids led to a remarkable plasticization effect on PLA, with a noticeable increase in ductile properties. In particular, the elongation at break of PLA, around 4.7%, was improved to values above 230% for all the plasticized formulations, even for low terpenoid concentration of 10 wt.%. Terpenoids also provide increased crystallinity because polymers chains have more mobility and are more readily arranged. This was observed by shifting the cold crystallization process to lower temperatures. As with other monomeric plasticizers, a clear decrease in the glass transition temperature from 61.5 °C (neat PLA), to values of around 40 °C for the plasticized formulations with 20 wt.% terpenoid was obtained. The obtained formulations show high potential since the plasticization efficiency of these terpenoids is very high, thus leading to new toughened-PLA formulations with improved ductility.
Job Satisfaction and Gender in Italy: A Structural Equation Modeling Approach
Authors: Piccitto Giorgio , Schadee Hans M. A. , Ballarino Gabriele 
Published: August 2023

AbstractThe aim of this study was to propose a reliable measurement model for the concept of job satisfaction in Italy and to test its measurement invariance across gender. We used the 2003 and 2009 Italian National Statistical Office (ISTAT) Family and Social Subjects (FSS) data, containing information on 8 dimensions of job satisfaction. The best-fitting model was a four-factor one, including the dimensions of intrinsic, rewards, timing and socio-contextual job satisfaction. Multi-group analysis supported the measurement invariance across gender. Additionally, we evaluated the role of several job and individual characteristics as determinants of job satisfaction for men and women. While for a number of them the patterns of association with job satisfaction were similar over genders, some differences also did emerge.
Random Lift of Set Valued Maps and Applications to Multiagent Dynamics
Authors: Capuani Rossana , Marigonda Antonio , Ricciardi Michele 
Published: August 2023

AbstractWe introduce an abstract framework for the study of general mean field games and mean field control problems. Given a multiagent system, its macroscopic description is provided by a time-depending probability measure, where at every instant of time the measure of a set represents the fraction of (microscopic) agents contained in it. The trajectories available to each of the microscopic agents are affected also by the overall state of the system. By using a suitable concept of random lift of set valued maps, together with fixed point arguments, we are able to derive properties of the macroscopic description of the system from properties of the set valued map expressing the admissible trajectories for the microscopical agents. The techniques used can be applied to consider a broad class of dependence between the trajectories of the single agent and the state of the system. We apply the results in the case in which the admissible trajectories of the agents are the minimizers of a suitable integral functional depending also from the macroscopic evolution of the system.
LC-HRMS method for study of pharmaceutical uptake in plants: effect of pH under aeroponic condition
Authors: Švecová Helena , Vojs Staňová Andrea , Klement Aleš , Kodešová Radka , Grabic Roman 
Published: August 2023

AbstractGlobal climate changes cause water scarcity in many regions, and the sustainable use of recycled water appears crucial, especially in agriculture. However, potentially hazardous compounds such as pharmaceuticals can enter the food chain and pose severe risks. This paper aims to study the presence of selected pharmaceutical active compounds (PhACs) and their metabolites in crops grown in aeroponic conditions and evaluate the potential of PhAC plant uptake. A solvent extraction with an acidified mixture of acetonitrile and water followed by LC-HRMS was developed and validated for quantifying nine pharmaceuticals and their nine metabolites in three plants. We aimed for a robust method with a wide linear range because an extensive concentration range in different matrices was expected. The developed method proved rapid and reliable determination of selected pharmaceuticals in plants in the wide concentration range of 10 to 20,000 ng g−1 and limit of detection range 0.4 to 9.0 ng g-1. The developed method was used to study the uptake and translocation of pharmaceuticals and their metabolites in plant tissues from an aeroponic experiment at three different pH levels. Carbamazepine accumulated more in the leaves of spinach than in arugula. On the other hand, sulfamethoxazole and clindamycin evinced higher accumulation in roots than in leaves, comparable in both plants. The expected effect of pH on plants’ uptake was not significant.
Creep and ageing of granular materials under isotropic pressure
Authors: Jessen Belinda Anna-Maria , Cudmani Roberto , Vogt Stefan 
Published: August 2023

AbstractSingle- and multi-stage isotropic creep tests including bender element and acoustic emission measurements are carried out to investigate the relationship between ageing and creep in dense silica sand. In the considered pressure range, the experimental results show an inversely proportional relationship between ageing and creep: the small-strain shear modulus increases with decreasing isotropic pressure,, while the axial creep strain and the acoustic emissions show the opposite pressure dependence. In the multi-stage creep test, the small-strain shear modulus increases monotonically, while the rates of axial strain, number of acoustic emissions and small-strain shear modulus decrease with time according to a power law. In the single-stage creep tests, the ageing and creep indicators initially evolve as in the multi-stage creep test, but then the small-strain shear modulus reaches a peak value and decreases with time thereafter. At the same time, the rates of axial strain, number of acoustic emissions and small-strain shear modulus deviate from the power law. A conceptual model assuming a time-dependent behaviour of the normal and shear forces at the particle contacts in order to explain the experimental observations qualitatively is proposed. Accordingly, an increase in small-strain shear modulus results from homogenisation of the force chains, while a decrease in small-strain shear modulus results from a temporary formation followed by a time-delayed collapse of strong force chains.
Sarcopenic Obesity and Cardiometabolic Health and Mortality in Older Adults: a Growing Health Concern in an Ageing Population
Authors: Wannamethee Sasiwarang Goya , Atkins Janice L. 
Published: August 2023

Abstract
Purpose of Review
Sarcopenic obesity (SO) is a growing public health problem in older adults. Whether SO confers higher risk of cardiometabolic disease and mortality than obesity or sarcopenia alone is still a matter of debate. We focus on recent findings on SO and cardiometabolic health and mortality in older adults.

Recent Findings
SO is associated with increased mortality compared to non-sarcopenic obesity, but similar mortality risk compared to sarcopenia without obesity. SO is associated with a higher risk of cardiovascular disease (CVD), diabetes, and physical disability than obesity or sarcopenia alone. SO, in the presence of diabetes, is associated with the highest risk of CVD and chronic kidney disease. A definition and diagnostic criteria for SO has recently been proposed (ESPEN and EASO).

Summary
SO is associated with more adverse outcomes overall than sarcopenia or obesity alone. Future research is required to assess the impact of the new SO definition on health outcomes.
Dual Endothelin Antagonism with Aprocitentan as a Novel Therapeutic Approach for Resistant Hypertension
Authors: Heidari Nejad Sayeh , Azzam Omar , Schlaich Markus P. 
Published: August 2023

Abstract
Purpose of Review
Resistant hypertension (RH) defined as uncontrolled blood pressure despite the use of a combination of a renin-angiotensin system blocker, a calcium channel blocker, and a diuretic at maximally tolerated doses is associated with a substantially increased risk of cardiovascular and renal events. Despite targeting relevant pathophysiological pathways contributing to elevated blood pressure, approximately 10–15% of hypertensive patients remain above recommended blood pressure targets. Further optimization of blood pressure control is particularly challenging in patient populations who frequently present with RH such as elderly and patients with chronic kidney disease, due to the unfavorable safety profile of the recommended fourth-line therapy with mineralocorticoid receptor antagonists. This review explores the potential role of endothelin antagonists as an alternative fourth-line therapy.

Recent Findings
Despite the well-described role of the endothelin pathway in the pathogenesis of hypertension, it is currently not targeted therapeutically. Recently however, main outcome data from the PRECISION study, a randomized placebo-controlled phase 3 trial, in patients with RH on guideline-recommended standardized single-pill background therapy convincingly demonstrated the safety and blood pressure-lowering efficacy of the dual endothelin antagonist Aprocitentan.

Summary
Findings from the phase 3 PRECISION study could signify a turning point in the utilization of endothelin receptor antagonists as a standard treatment for patients with RH.
Advances, challenges and perspective in modelling the functioning of karst systems: a review
Authors: Jourde Hervé , Wang Xiaoguang 
Published: August 2023

AbstractWe present a discussion of the state-of-the art on modelling geometrical characteristics, hydrogeological behavior and geochemical evolution of karst aquifers of meteoric origin. The considered key karst processes include: (1) the recharge processes, (2) the various hydrodynamic processes in the vadose and phreatic zones, (3) the related transport processes and (4) the speleogenesis processes. Different types of approaches for modelling geometrical characteristics of karst conduit networks are summarized. Integrated numerical studies on hydrogeological behavior of karst aquifers with functional and physically based models are then reviewed. Challenging issues in karst modelling are further discussed based on previous modelling progresses. The paper finally offers recommendations for advancing the modelling of hydrogeological behavior of karst systems and lists several open questions for future research.
Shed skin as a source of DNA for genotyping-by-sequencing (GBS) in reptiles
Authors: Brekke Thomas D , Shier Liam , Hegarty Matthew J , Mulley John F 
Published: August 2023

AbstractOver a fifth of reptile species are classified as ‘Threatened’ and conservation efforts, especially those aimed at recovery of isolated or fragmented populations, will require genetic and genomic data and resources. Shed skins of snakes and other reptiles contain DNA; are a safe and ethical way of non-invasively sampling large numbers of individuals; and provide a simple mechanism by which to involve the public in scientific research. Here we test whether the DNA in dried shed skin is suitable for reduced representation sequencing approaches, specifically genotyping-by-sequencing (GBS). Shed skin-derived libraries resulted in fewer sequenced reads than those from snap-frozen muscle samples, and contained slightly fewer variants (70,685 SNPs versus 97,724), but this issue can easily be rectified with deeper sequencing of shed skin-derived libraries. Skin-derived libraries also have a very slight (but significantly different) profile of transitions and transversions, most likely as a result of DNA damage, but the impact of this is minimal given the large number of single nucleotide polymorphisms (SNPs) involved. SNP density tends to scale with chromosome length, and microchromosomes have a significantly higher SNP density than macrochromosomes, most likely because of their higher GC content. Overall, shed skin provides DNA of sufficient quality and quantity for the identification of large number of SNPs, but requires greater sequencing depth, and consideration of the GC richness of microchromosomes when selecting restriction enzymes.
The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
Authors: Chen Si , Wang Nan , Xiong Siqi , Xia Xiaobo 
Published: August 2023

Abstract
Background
Glaucoma is the leading cause of irreversible blindness worldwide. Emerged evidence has shown that glaucoma is considered an immune system related disorder. The gut is the largest immune organ in the human body and the gut microbiota (GM) plays an irreversible role in maintaining immune homeostasis. But, how the GM influences glaucoma remains unrevealed. This study aimed at investigating the key molecules/pathways mediating the GM and the glaucoma to provide new biomarkers for future predictive, preventive, and personalized medicine.

Methods
Datasets from the primary open-angle glaucoma (POAG) patients (GSE138125) and datasets for target genes of GM/GM metabolites were downloaded from a public database. For GSE138125, the differentially expressed genes (DEGs) between healthy and POAG samples were identified. And the online Venn diagram tool was used to obtain the DEGs from POAG related to GM. After which GM-related DEGs were analyzed by correlation analysis, pathway enrichment analysis, and protein–protein interaction (PPI) network analysis. Human trabecular meshwork cells were used for validation, and the mRNA level of hub genes was verified by quantitative real-time polymerase chain reaction (RT-qPCR) in the in vitro glaucoma model.

Results
A total of 16 GM-related DEGs in POAG were identified from the above 2 datasets (9 upregulated genes and 7 downregulated genes). Pathway enrichment analysis indicated that these genes are mostly enriched in immune regulation especially macrophages-related pathways. Then 6 hub genes were identified by PPI network analysis and construction of key modules. Finally, RT-qPCR confirmed that the expression of the hub genes in the in vitro glaucoma model was consistent with the results of bioinformatics analysis of the mRNA chip.

Conclusion
This bioinformatic study elucidates NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as hub genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Scientific experiments beyond surprise and beauty
Authors: Kozlov Anatolii 
Published: August 2023

AbstractSome experimental results in science are productively surprising or beautiful. Such results are disruptive in their epistemic nature: by violating epistemic expectations they mark the phenomenon at hand as worthy of further investigation. Could it be that there are emotions beyond these two which are also useful for the epistemic evaluation of scientific experiments? Here, I conduct a structured sociological survey to explore affective experiences in scientific experimental research. I identify that learning the results of an experiment is the high emotional point in the experimenting process. Thus, experimental results can be challenging, beautiful, or boring, and they can worry, amuse, make one sad, and so on. They can also drive meta-cognitive evaluations as well as motivate specific research-related actions. From this, I advance two claims: that emotions beyond surprise and disruptive beauty are epistemically useful in empirical research, and that emotions help to overcome specific challenges of reasoning about new experimental results.
Spatiotemporal patterns of water hyacinth dynamics as a response to seasonal climate variability in Lake Tana, Ethiopia
Authors: Abebe Takele , Awoke Berhan Gessesse , Nega Worku 
Published: August 2023

AbstractLake Tana, which is the largest Lake in Ethiopia, has been invaded by water hyacinths since 2011. Although the government and the community have devoted considerable time and energy over a long period to removing the invasive weed mechanically and manually, the weed has been increasing significantly. Accurate, reliable, and timely information on the spatiotemporal distribution and extent of water hyacinth is crucial to determine its evolution, propagation, and potentially vulnerable areas of the Lake. Therefore, comprehensive information on the spatial distribution of water hyacinths and their annual and seasonal variability is essential for Lake Tana’s water resource planning, development, and management. This study aims to evaluate the spatiotemporal pattern of water hyacinth and its dynamics with seasonal climate variability and impact on evapotranspiration. Landsat 7 ETM+, Landsat 8 OLI, and Sentinel 2 and meteorological datasets were employed. Supervised and manual digitization image classification methods were applied to prepare Land-use/ Land-cover in the Lake. The Mann–Kendall trend test and Pearson correlation coefficient were used to evaluate the trend of water hyacinth and the impact of climate variability on water hyacinth distribution respectively. Besides, the evapotranspiration and water losses were estimated using the FAO-56 Penman–Monteith method. The surface extent of the water hyacinth in Lake Tana has increased by 96% in 2019 from 2011. However, the surface area of the Lake has declined. That means 1603 ha of water surface area has been changed to land surface from 2011 to 2019. The average volume of water loss in Lake Tana was 0.21% of the volume of the Lake from September 2016 to December 2018.
Spatiotemporal Event Studies for Environmental Data Under Cross-Sectional Dependence: An Application to Air Quality Assessment in Lombardy
Authors: Maranzano Paolo , Pelagatti Matteo 
Published: August 2023

AbstractWe propose a twofold adjustment for Event Studies considering spatiotemporal data in a multivariate time series framework where the data are characterized by spatial and temporal dependence. The first adjustment consists of modeling the spatiotemporal dynamics of the data by implementing several geostatistical models capable of handling both spatial and temporal components, as well as estimating the relationship between the response variable and a set of exogenous factors. With the second adjustment, we propose to use cross-sectional-adjusted test statistics directly accounting for spatial cross-correlation. The proposed methods are applied to the case of NO$$_2$$

2

concentrations observed in Northern Italy during the first wave of the COVID-19 pandemic. The key findings are as follows. First, all the considered geostatistical models estimate larger reductions in the major metropolitan and congested areas, while smaller reductions are estimated in rural plains and in the mountains. Second, the models are nearly equivalent in terms of fitting and are capable of identifying the true event window. Third, by using spatiotemporal models we ensure the residuals are uncorrelated across space and time, thus allowing Event Studies test statistics to provide reliable and realistic estimates. Fourth, as expected, all test statistics show significant reductions in NO$$_2$$

2

concentrations starting from the first few days of lockdown. Supplementary materials accompanying this paper appear online.