bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival of oral tongue cancer in low middle-income country: a cohort study
Authors: Ukrani Ronika Devi , Danish Muhammad Hassan , Ikram Mubasher , Nathani Karim Rizwan , Salim Shaharyar , Muhammad Adnan Yar , Rozi Shafquat , Zahid Nida , Iftikhar Haissan 
Published: April 2023

Abstract

Introduction
The incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing. OTSCC is comparatively higher in our region owing to the consumption of tobacco, beetle nut, alcohol, and poor oral hygiene. There is paucity of survival data for OTSCC from our high-burden region.

Background
There is paucity of survival data for OTSCC from our high-burden region, we aimed to determine 5-year overall and disease-free survival of patients with OTSCC.

Methods
A retrospective chart review was conducted for all the patients treated for oral tongue squamous cell carcinoma from January 2000 and December 2013. The data on overall survival and disease-free survival was collected via telephonic interviews up till 2018. Kaplan Meier curves were plotted to graphically represent survival.

Results
A total of 131 patients were included. The mean age of the patients was 49.4 ± 12.98 years, with most patients being male (65.9%). The most common tumor stage was T2 (55.1%) and the most common nodal stage was N0 (57.7%). Five-year disease-free survival was 59.2%, and overall survival was 60.7%. Overall survival dropped steeply from 84.4 to 7.5% in patients who developed recurrence in our cohort.

Conclusion
The most significant factor influencing the survival of patients with OTSCC is tumor recurrence. 5-year recurrence-free survival was 84.4% which is greater than reported in literature. This could be due to the low incidence of perineural and perivascular invasion in our population. Further research on factors leading to recurrence should be done.
Prevalence and clinico-bacteriological aspects of chronic suppurative otitis media at the Renaissance University Hospital in N'Djamena, Chad
Authors: Taoussi Aboubakar Assidick , Malloum Mahamat Seïd Mahamat , Ali Yusra Aboulbachar 
Published: April 2023

Abstract
Background
Chronic suppurative otitis media is a major cause of hearing impairment and morbidity in poor socioeconomic developing countries.

Objectives
To determine the prevalence of chronic suppurative otitis media in a tertiary care hospital and to analyze its clinico-bacteriological aspects.

Methods
This is a cross-sectional, descriptive and analytical study conducted at the ENT and Head and Neck Surgery Department in the Renaissance University Hospital in N'Djamena, Chad. All the patients that were diagnosed with chronic suppurative otitis media from 1 January 2017 to 31 December 2019 were included.

Results
The hospital prevalence was 6.1%. The sex ratio (male/female) was 1.09. The median age of patients was 28 years with [1 to 74 years]. The median time from the onset of otorrhea to coming for medical consultation was 6 years with [4 months to 42 years]. The main symptom associated with otorrhea was hearing impairment which was in 55.6% of cases (n = 50). Perforations ≥ ¾ of the tympanic membrane surface were noted in 51.3% of cases (n = 60). The tympanic cavity floor was erythematous in 49.6% of cases (n = 58) and erythematous with a discharge in 42.7% of cases (n = 50). There was an association between the size of the perforation and the appearance of the tympanic mucosa (p = 0.003), and between the age of the disease and the side of the ear affected with chronic suppurative otitis media (p = 0.016). The culture positivity rate was 86.1% (n = 31) and with two other microbial cases. Staphylococcus aureus was isolated in 28.1% of cases (n = 9) followed by Pseudomonas aeruginosa which was 25% of the cases (n = 8).

Conclusion
Chronic suppurative otitis media affects both children and adults. Delay in medical consultation to the ENT department is relatively high. Staphylococcus aureus and Pseudomonas aeruginosa are the most common causes.
Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets
Authors: Tsume Yasuhiro , Ashworth Lee , Bermejo Marival , Cheng Joan , Cicale Vincent , Dressman Jennifer , Fushimi Masahiro , Gonzalez-Alvarez Isabel , Guo Yiwang , Jankovsky Corinne , Lu Xujin , Matsui Kazuki , Patel Sanjaykumar , Sanderson Natalie , Sun Changquan Calvin , Thakral Naveen K. , Yamane Miki , Zöller Laurin 
Published: April 2023

AbstractAssessing in vivo performance to inform formulation selection and development decisions is an important aspect of drug development. Biopredictive dissolution methodologies for oral dosage forms have been developed to understand in vivo performance, assist in formulation development/optimization, and forecast the outcome of bioequivalence studies by combining them with simulation tools to predict plasma profiles in humans. However, unlike compendial dissolution methodologies, the various biopredictive methodologies have not yet been harmonized or standardized. This manuscript presents the initial phases of an effort to develop best practices and move toward standardization of the biopredictive methodologies through the Product Quality Research Institute (PQRI, https://pqri.org) entitled “The standardization of in vitro predictive dissolution methodologies and in silico bioequivalence study Working Group.” This Working Group (WG) is comprised of participants from 10 pharmaceutical companies and academic institutes. The project will be accomplished in a total of five phases including assessing the performance of dissolution protocols designed by the individual WG members, and then building “best practice” protocols based on the initial dissolution profiles. After refining the “best practice” protocols to produce equivalent dissolution profiles, those will be combined with physiologically based biopharmaceutics models (PBBM) to predict plasma profiles. In this manuscript, the first two of the five phases are reported, namely generating biopredictive dissolution profiles for ibuprofen and dipyridamole and using those dissolution profiles with PBBM to match the clinical plasma profiles. Key experimental parameters are identified, and this knowledge will be applied to build the “best practice” protocol in the next phase.
Graphical Abstract
Burosumab vs Phosphate/Active Vitamin D in Pediatric X-Linked Hypophosphatemia: A Subgroup Analysis by Dose Level
Authors: Imel Erik A , Glorieux Francis H , Whyte Michael P , Portale Anthony A , Munns Craig F , Nilsson Ola , Simmons Jill H , Padidela Raja , Namba Noriyuki , Cheong Hae Il , Pitukcheewanont Pisit , Sochett Etienne , Högler Wolfgang , Muroya Koji , Tanaka Hiroyuki , Gottesman Gary S , Biggin Andrew , Perwad Farzana , Chen Angel , Roberts Mary Scott , Ward Leanne M 
Published: April 2023

Abstract

Context
In an open-label, randomized, controlled, phase 3 trial in 61 children aged 1 to 12 years with X-linked hypophosphatemia (XLH), burosumab improved rickets vs continuing conventional therapy with active vitamin D and phosphate.

Objective
We conducted an analysis to determine whether skeletal responses differed when switching to burosumab vs continuing higher or lower doses of conventional therapy.

Methods
Conventional therapy dose groups were defined as higher-dose phosphate [greater than 40 mg/kg] (HPi), lower-dose phosphate [40 mg/kg or less] (LPi), higher-dose alfacalcidol [greater than 60 ng/kg] or calcitriol [greater than 30 ng/kg] (HD), and lower-dose alfacalcidol [60 ng/kg or less] or calcitriol [30 ng/kg or less] (LD).

Results
At week 64, the Radiographic Global Impression of Change (RGI-C) for rickets was higher (better) in children randomly assigned to burosumab vs conventional therapy for all prebaseline dose groups: HPi (+1.72 vs +0.67), LPi (+2.14 vs +1.08), HD (+1.90 vs +0.94), LD (+2.11 vs +1.06). At week 64, the RGI-C for rickets was also higher in children randomly assigned to burosumab (+2.06) vs conventional therapy for all on-study dose groups: HPi (+1.03), LPi (+1.05), HD (+1.45), LD (+0.72). Serum alkaline phosphatase (ALP) also decreased in the burosumab-treated patients more than in the conventional therapy group, regardless of on-study phosphate and active vitamin D doses.

Conclusion
Prior phosphate or active vitamin D doses did not influence treatment response after switching to burosumab among children with XLH and active radiographic rickets. Switching from conventional therapy to burosumab improved rickets and serum ALP more than continuing either higher or lower doses of phosphate or active vitamin D.
Successful Treatment of Hypoglycemia With Alpelisib in Pediatric Patients With PIK3CA-Related Overgrowth Spectrum
Authors: Nasomyont Nat , Rutter Meilan M , Backeljauw Philippe F 
Published: April 2023

Abstract
Activating mutations in the PIK3CA gene, causing phosphoinositide 3-kinase (PI3K) hyperactivation, are rare causes of hypoglycemia. We report the novel use of alpelisib (a PI3K inhibitor) for the treatment of hypoketotic, hypoinsulinemic hypoglycemia in 2 children with PIK3CA-related overgrowth spectrum (PROS). Patient 1 was a 7-month-old girl who presented with a hypoglycemic seizure. Despite nutritional management including continuous feeds, she continued to have frequent hypoglycemia. At age 2.8 years, alpelisib was started at 50 mg daily and titrated to 100 mg daily. She was weaned off nocturnal continuous feeds by 8 months. She developed colitis when the alpelisib dose was increased to 125 mg, but this resolved with a dose decrease and medical management. At age 5.3 years, she was doing well with rare hypoglycemia. Her accelerated growth stabilized. Patient 2 was a 3-year-old boy who developed hypoglycemia in early infancy. Alpelisib 50 mg daily was started due to recurrent hypoglycemia despite nutritional management. He came off continuous feeds after 4 months, with decreased hypoglycemia frequency. At age 4.5 years, he had not experienced side effects from treatment. In conclusion, alpelisib appears to be effective in decreasing PROS-related hypoglycemia frequency and severity and should be considered for refractory hypoglycemia in this condition.
Coethnic, Multicultural, or Cosmopolitan? Cultural Citizenship, Enfranchisement, and the Contested Category of Korean-Chinese in Globalizing South Korea
Authors: Han Seung-Mi 
Published: April 2023

AbstractThis article deals with the Korean-Chinese politics of recognition in contemporary South Korea. Unlike North Korean settlers who are “technically” embraced from the outset as coethnics, the Korean-Chinese are located in the interstices of the Act on the Employment of Foreign Workers, the Overseas Koreans Act, and the Multicultural Families Support Act. By analyzing how the Korean-Chinese politics of belonging is mediated by competing models of nationalism, multiculturalism, and political participation that Korean-Chinese bring with them from the People’s Republic of China and encounter anew in South Korea, the article puts into relief the various choices available to these migrants and their emotionally-charged disagreements over how to define themselves culturally and politically. Juxtaposing Korean-style multicultural policy with a curiously muted cultural distinctiveness in the Korean-Chinese politics of recognition, the article argues for the importance of cherishing cultural diversity in the public sphere, even for the coethnic politics of belonging.
Training the Ear and Remixing the Archive in Looking for Langston
Authors: Kraeher Rudi 
Published: April 2023

Abstract
This essay argues for a close attention to the use of sound in the audiovisual aesthetics of Isaac Julien's seminal New Queer Cinema film Looking for Langston (1989). The analysis relies on Amber Musser's work on “sensation” as an analytic for corporeal knowledge production and performs a series of close readings that highlight the influential role of musical remixing practices in the film's synchronization of sound and image. Remixing practices such as sampling provide a music-based conceptual vocabulary, which helps to illuminate how the montage of Looking for Langston is structured by its sonic elements. The essay shows how Looking for Langston promotes an open-ended orientation toward the archive that eschews artifact discovery and epistemologies of certainty. Instead, embracing the possibilities of archival work that is guided by our bodily sensations and desires, the film offers an alternative disposition toward queer of color archives that celebrates the possibilities of speculative fantasy, opacity, and disorientation. Furthermore, the essay shows, not only is the film's use of sound interesting in its divergence from the conventions of sound synchronization within many documentary and narrative cinematic forms, but the film is also particularly notable for how it actively draws on practices from contemporary musical culture (specifically late 1980s house music) in order to produce a thoroughly sound-based cinematic montage.
Single-Posterior Revision Surgery for Recurrent Thoracic/Thoracolumbar Spinal Tuberculosis With Kyphosis
Authors: Yang Kai , Feng Chaoshuai , Zheng Bolong , Hui Hua , Kong Lingbo , Yan Liang , Hao Dingjun , He Baorong 
Published: April 2023

BACKGROUND AND OBJECTIVES:
The treatment of thoracic/thoracolumbar spinal tuberculosis (STB) remains challenging. The spinal deformity, long disease history, heterogeneous lesion, and poor drug response make the treatment of recurrent and kyphosis cases even more difficult. This study aims to investigate the efficacy and safety of single-posterior revision surgery in patients with recurrent thoracic/thoracolumbar STB and kyphosis.

METHODS:
Patients with recurrent thoracic/thoracolumbar STB with kyphosis and treated with single-posterior debridement, osteotomy, correction, bone graft, and fusion in our center from 2009 to 2019 were enrolled. The clinical data, radiographs, and erythrocyte sedimentation rate (ESR) at different stages were collected. ESR, kyphotic angle, Visual Analog Scale, and neurological functions were analyzed.

RESULTS:
A total of 27 patients (16 male, 11 female) with an average age of 48.4 ± 13.0 years were included. The average surgery time was 320.6 ± 46.4 minutes, and the average estimated blood loss was 1470.6 ± 367.4 mL. From admittance to the latest follow-up, the average Visual Analog Scale significantly reduced from 5.6 ± 1.3 to 0.5 ± 0.7, the average ESR was improved from 69.4 ± 15.8 mm/h to normal, and the average kyphotic angle was corrected from 66.6° ± 11.7° to 34.5° ± 6.6°. For patients with preoperative neurological deficits, their neurological functions were improved to normal. In drug susceptibility tests, 70.5% (11/17) of specimens had bacteria resistant to at least 1 first-line drug.

CONCLUSION:
Single-posterior debridement, osteotomy, correction, bone graft, and fusion are effective and safe in the treatment of recurrent thoracic/thoracolumbar spinal tuberculosis with kyphosis. The drug treatment of recurrent spinal tuberculosis should be carefully tailored.
Three-Dimensional Modeling and Extended Reality Simulations of the Cross-Sectional Anatomy of the Cerebrum, Cerebellum, and Brainstem
Authors: Gurses Muhammet Enes , Hanalioglu Sahin , Mignucci-Jiménez Giancarlo , Gökalp Elif , Gonzalez-Romo Nicolas I. , Gungor Abuzer , Cohen-Gadol Aaron A. , Türe Uğur , Lawton Michael T. , Preul Mark C. 
Published: April 2023

BACKGROUND:
Understanding the anatomy of the human cerebrum, cerebellum, and brainstem and their 3-dimensional (3D) relationships is critical for neurosurgery. Although 3D photogrammetric models of cadaver brains and 2-dimensional images of postmortem brain slices are available, neurosurgeons lack free access to 3D models of cross-sectional anatomy of the cerebrum, cerebellum, and brainstem that can be simulated in both augmented reality (AR) and virtual reality (VR).

OBJECTIVE:
To create 3D models and AR/VR simulations from 2-dimensional images of cross-sectionally dissected cadaveric specimens of the cerebrum, cerebellum, and brainstem.

METHODS:
The Klingler method was used to prepare 3 cadaveric specimens for dissection in the axial, sagittal, and coronal planes. A series of 3D models and AR/VR simulations were then created using 360° photogrammetry.

RESULTS:
High-resolution 3D models of cross-sectional anatomy of the cerebrum, cerebellum, and brainstem were obtained and used in creating AR/VR simulations. Eleven axial, 9 sagittal, and 7 coronal 3D models were created. The sections were planned to show important deep anatomic structures. These models can be freely rotated, projected onto any surface, viewed from all angles, and examined at various magnifications.

CONCLUSION:
To our knowledge, this detailed study is the first to combine up-to-date technologies (photogrammetry, AR, and VR) for high-resolution 3D visualization of the cross-sectional anatomy of the entire human cerebrum, cerebellum, and brainstem. The resulting 3D images are freely available for use by medical professionals and students for better comprehension of the 3D relationship of the deep and superficial brain anatomy.
Correlation Among Syrinx Resolution, Cervical Sagittal Realignment, and Surgical Outcome After Posterior Reduction for Basilar Invagination, Atlantoaxial Dislocation, and Syringomyelia
Authors: Lu Chunli , Duan Wanru , Zhang Can , Du Yueqi , Wang Xinyu , Ma Longbing , Wang Kai , Wu Hao , Chen Zan , Jian Fengzeng 
Published: April 2023

BACKGROUND:
The correlation among syrinx resolution, occipitoaxial sagittal alignment, and surgical outcome in long-term follow-up seems to have not been clarified.

OBJECTIVE:
To further explore the relationship between the syrinx resolution and occipitoaxial realignment after posterior reduction and fixation in basilar invagination (BI)-atlantoaxial dislocation (AAD) patients with syringomyelia.

METHODS:
A continuous series of 32 patients with BI-AAD and syringomyelia who received direct posterior reduction met the inclusion criteria of this study. Their clinical and imaging data were analyzed retrospectively. Before surgery and at the last follow-up, we used the Japanese Orthopedic Association (JOA) score and the Neck Disability Index (NDI) to assess the neurological status, respectively. The Pearson correlation coefficient and multiple stepwise regression analysis were used to explore the relevant factors that may affect surgical outcomes.

RESULTS:
There were significant differences in atlantodental interval, clivus-axial angle, occiput-C2 angle (Oc-C2A), cervicomedullary angle (CMA), subarachnoid space (SAS) at the foramen magnum (FM), syrinx size, NDI, and JOA score after surgery compared with those before surgery. ΔCMA and the resolution rate of syrinx/cord as relevant factors were correlated with the recovery rate of JOA (R2 = 0.578, P < .001) and NDI (R2 = 0.369, P < .01). What's more, ΔSAS/FMD (SAS/FM diameter) and ΔOc-C2A were positively correlated with the resolution rate of syrinx/cord (R2 = 0.643, P < .001).

CONCLUSION:
With medulla decompression and occipital-cervical sagittal realignment after posterior reduction and fusion for BI-AAD patients with syringomyelia, the structural remodeling of the craniovertebral junction and occipitoaxial realignment could contribute to syringomyelia resolution.
One-Insertion Stereotactic Brain Biopsy Using In Vivo Optical Guidance—A Case Study
Authors: Wårdell Karin , Klint Elisabeth , Milos Peter , Richter Johan 
Published: April 2023

BACKGROUND:
Stereotactic neurosurgical brain biopsies are afflicted with risks of inconclusive results and hemorrhage. Such complications can necessitate repeated trajectories and prolong surgical time.

OBJECTIVE:
To develop and introduce a 1-insertion stereotactic biopsy kit with direct intraoperative optical feedback and to evaluate its applicability in 3 clinical cases.

METHODS:
An in-house forward-looking probe with optical fibers was designed to fit the outer cannula of a side-cutting biopsy kit. A small aperture was made at the tip of the outer cannula and the edges aligned with the optical probe inside. Stereotactic biopsies were performed using the Leksell Stereotactic System. Optical signals were measured in millimeter steps along the preplanned trajectory during the insertion. At the region with the highest 5-aminolevulinic acid (5-ALA)–induced fluorescence, the probe was replaced by the inner cannula, and tissue samples were taken. The waiting time for pathology diagnosis was noted.

RESULTS:
Measurements took 5 to 10 minutes, and the surgeon received direct visual feedback of intraoperative 5-ALA fluorescence, microcirculation, and tissue gray-whiteness. The 5-ALA fluorescence corroborated with the pathological findings which had waiting times of 45, 50, and 75 minutes. Because only 1 trajectory was required and the patient could be prepared for the end of surgery immediately after sampling, this shortened the total surgical time.

CONCLUSION:
A 1-insertion stereotactic biopsy procedure with real-time optical guidance has been presented and successfully evaluated in 3 clinical cases. The method can be modified for frameless navigation and thus has great potential to improve safety and diagnostic yield for both frameless and frame-based neurosurgical biopsy procedures.
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Authors: Lin Huijuan , Cossu Isabella G. , Leu N. Adrian , Deshpande Aniruddha J. , Bernt Kathrin M. , Luo Mengcheng , Wang P. Jeremy 
Published: April 2023

ABSTRACT
Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential for embryonic development. Here, we report that DOT1L regulates male fertility in mouse. DOT1L associates with MLLT10 in testis. DOT1L and MLLT10 localize to the sex chromatin in meiotic and post-meiotic germ cells in an inter-dependent manner. Loss of either DOT1L or MLLT10 leads to reduced testis weight, decreased sperm count and male subfertility. H3K79me2 is abundant in elongating spermatids, which undergo the dramatic histone-to-protamine transition. Both DOT1L and MLLT10 are essential for H3K79me2 modification in germ cells. Strikingly, histones are substantially retained in epididymal sperm from either DOT1L- or MLLT10-deficient mice. These results demonstrate that H3K79 methylation promotes histone replacement during spermiogenesis.