bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crowdfunding performance, market performance, and the moderating roles of product innovativeness and experts' judgment: Evidence from the movie industry
Authors: Roma Paolo , Natalicchio Angelo , Panniello Umberto , Vasi Maria , Messeni Petruzzelli Antonio 
Published: January 2023

AbstractReward‐based crowdfunding (CF) has emerged as a method to solicit funds for innovative projects. Yet, little is still known about the ability of reward‐based CF to act as a signal in the eyes of future consumers, and thus boost the future market performance of new products that innovators intend to commercialize using the campaign funds. In addition, scant research has clarified the boundary conditions that can magnify or weaken the efficacy of this CF signal. Given the relevance of reward‐based CF for supporting innovation, understanding when the CF campaign performance works as an effective signal is of great interest, especially in business settings characterized by high product quality uncertainty. By using the movie industry as a setting, we contribute to fill this gap. Specifically, we argue that the positive effect of the reward‐based CF performance is moderated by two important factors influencing consumers' purchase decisions: the degree of product innovativeness and the expert judgment about the product. Elaborating on the effects of product innovativeness, we posit that this product feature should moderate the positive relationship between CF and subsequent market performances in an inverted U‐shaped fashion. Favorable expert recommendations, on the other hand, should weaken the efficacy of the CF performance as a signal. Results from a sample of 1059 new movies (of which 152 released in theaters) confirm these predictions and offer several remarkable implications for innovators.
Amyloid precursor protein 𝛽CTF accumulates in synapses in sporadic and genetic forms of Alzheimer's disease
Authors: Ferrer‐Raventós Paula , Puertollano‐Martín David , Querol‐Vilaseca Marta , Sánchez‐Aced Érika , Valle‐Tamayo Natalia , Cervantes‐Gonzalez Alba , Nuñez‐Llaves Raúl , Pegueroles Jordi , Dols‐Icardo Oriol , Iulita Maria Florencia , Aldecoa Iban , Molina‐Porcel Laura , Sánchez‐Valle Raquel , Fortea Juan , Belbin Olivia , Sirisi Sònia , Lleó Alberto 
Published: January 2023

AbstractAimsAmyloid precursor protein (APP) 𝛽‐C‐terminal fragment (𝛽CTF) may have a neurotoxic role in Alzheimer's disease (AD). 𝛽CTF accumulates in the brains of patients with sporadic (SAD) and genetic forms of AD. Synapses degenerate early during the pathogenesis of AD. We studied whether the 𝛽CTF accumulates in synapses in SAD, autosomal dominant AD (ADAD) and Down syndrome (DS).MethodsWe used array tomography to determine APP at synapses in human AD tissue. We measured 𝛽CTF, A𝛽40, A𝛽42 and phosphorylated tau181 (p‐tau181) concentrations in brain homogenates and synaptosomes of frontal and temporal cortex of SAD, ADAD, DS and controls.ResultsAPP colocalised with pre‐ and post‐synaptic markers in human AD brains. APP 𝛽CTF was enriched in AD synaptosomes.ConclusionsWe demonstrate that 𝛽CTF accumulates in synapses in SAD, ADAD and DS. This finding might suggest a role for 𝛽CTF in synapse degeneration. Therapies aimed at mitigating 𝛽CTF accumulation could be potentially beneficial in AD.
Differences in Parkinson's disease treatment between neurology and other departments in Japan
Authors: Tsuboi Yoshio , Wada‐Isoe Kenji , Kondo Hiroyuki , Kojima Yoshitsugu , Takeshima Tomomi , Iwasaki Kosuke 
Published: January 2023

AbstractBackgroundParkinson's disease is common in elderly people and is treated in the neurology department as well as in other departments. Recently, treatment options for Parkinson's disease have expanded; this complicates selection of the best treatment regimen.AimTo investigate the change in Parkinson's disease treatment in Japan and assess the differences in prescriptions between neurology and other departments.MethodsPatients with Parkinson's disease who were prescribed levodopa and/or non‐ergot dopamine agonist were analyzed in an observational study using a Japanese claims database (April 2008–July 2017). The percentage of patients receiving each antiparkinsonian drug and the proportion of patients prescribed levodopa alone, levodopa plus non‐ergot dopamine agonist, and non‐ergot dopamine agonist alone were calculated by year (2010–2017) and department (neurology or other departments).ResultsWe identified 50,408 patients (mean [standard deviation] age: 73.4 [10.3]), including 25,231 (71.3 [10.1]) and 25,177 (75.5 [10.2]) patients who received their initial Parkinson's disease treatment in neurology and other departments, respectively. The popularity of levodopa alone and levodopa plus non‐ergot‐ dopamine agonist varied in the neurology department, while levodopa alone was the most popular treatment choice in all investigated years in other departments.ConclusionsThe number of patients initially treated for Parkinson's disease in neurology department, relative to other departments, did not differ. The treatment changes were observed in the neurology department but not in other departments.
Functional genomics gives new insights into the ectomycorrhizal degradation of chitin
Authors: Maillard François , Kohler Annegret , Morin Emmanuelle , Hossann Christian , Miyauchi Shingo , Ziegler‐Devin Isabelle , Gérant Dominique , Angeli Nicolas , Lipzen Anna , Keymanesh Keykhosrow , Johnson Jenifer , Barry Kerrie , Grigoriev Igor V. , Martin Francis M. , Buée Marc 
Published: January 2023

Summary

Ectomycorrhizal (EcM) fungi play a crucial role in the mineral nitrogen (N) nutrition of their host trees. While it has been proposed that several EcM species also mobilize organic N, studies reporting the EcM ability to degrade N‐containing polymers, such as chitin, remain scarce.

Here, we assessed the capacity of a representative collection of 16 EcM species to acquire 15N from 15N‐chitin. In addition, we combined genomics and transcriptomics to identify pathways involved in exogenous chitin degradation between these fungal strains.

Boletus edulis, Imleria badia, Suillus luteus, and Hebeloma cylindrosporum efficiently mobilized N from exogenous chitin. EcM genomes primarily contained genes encoding for the direct hydrolysis of chitin. Further, we found a significant relationship between the capacity of EcM fungi to assimilate organic N from chitin and their genomic and transcriptomic potentials for chitin degradation.

These findings demonstrate that certain EcM fungal species depolymerize chitin using hydrolytic mechanisms and that endochitinases, but not exochitinases, represent the enzymatic bottleneck of chitin degradation. Finally, this study shows that the degradation of exogenous chitin by EcM fungi might be a key functional trait of nutrient cycling in forests dominated by EcM fungi.
Prognostic nomogram for patients with tongue squamous cell carcinoma: A SEER‐based study
Authors: Gu Yifan , Qian Cheng , Yu Lu , Fang Hongzhe , Wang Jintao , Wu Peipei , Zhong Liangjun , Liu Kai , He Rui 
Published: January 2023

AbstractObjectivesIn order to predict the patients' prognosis with tongue squamous cell carcinoma (SCC), this study set out to develop a clinically useful and trustworthy prognostic nomogram.Subjects and MethodsThe Surveillance, Epidemiology, and End Results (SEER) Program was used to compile clinical information on patients with tongue SCC between 2010 and 2015. The likelihood of Cancer‐Specific Survival (CSS) and Overall Survival (OS) for specific patients was predicted using a prognostic nomogram created with the help of the RStudio software. The nomogram's predictive ability was evaluated using the consistency index (C‐index) and decision curve analysis, and the nomogram was calibrated for 1‐, 2‐, 3‐, 5‐, and 10‐year CSS and OS.ResultsPatients numbering 6453were enrolled in this study. The primary cohort (3895) and validation cohort (2558) were each randomly assigned. Sex, age, tumor‐node‐metastasis (TNM) stage, surgery, chemotherapy, and radiation were significant risk factors for OS, whereas age, TNM stage, surgery, chemotherapy, and radiotherapy were significant risk factors for CSS. Additionally, C‐index and calibration curves indicated that the prognostic nomogram prediction and the actual observation in both cohorts would be very coherent.ConclusionsThe predictive nomogram created in this study can offer patients with tongue SCC customized treatment and survival risk assessment.
Osteogenic effect of crocin in human periodontal ligament stem cells via Wnt/β‐catenin signaling
Authors: Gu Yingzhi , Bai Yuxing 
Published: January 2023

AbstractObjectivesCrocin is a major class of medicinal components in saffron. This study aimed to determine whether crocin directly promotes the proliferation and osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) in vitro and in vivo.Materials and MethodsCCK8 cell proliferation assay, reverse transcription quantitative polymerase chain reaction (RT–qPCR), Western blot analysis and Alizarin Red staining were performed in PDLSCs using crocin as a stimulant. DKK1 was used to selectively inhibit Wnt/β‐catenin signaling, and Western blotting was performed to investigate the underlying mechanism. The PDLSCs were mixed with calcium phosphate cement and implanted into nude mice subcutaneously to study the effect of crocin on PDLSC osteogenic differentiation in vivo.ResultsThe CCK‐8 assay showed that crocin did not promote the proliferation of PDLSCs. Treatment with 400 μM crocin significantly promoted PDLSC mRNA levels of ALP, COL1 and OCN; RUNX2 and BMP2 protein expression; mineralized nodule formation in vitro and in vivo; and ALP activity in tissues in vivo. In addition, crocin significantly promoted the phosphorylation of β‐catenin and cyclin D1. DKK1 inhibits Wnt/β‐catenin activation and partially reverses crocin‐mediated promotion of PDLSC osteogenic differentiation.ConclusionCrocin may contribute to the regeneration of periodontal bone tissue.
Salvianolic acid B as a potent nano‐agent for enhanced ALA‐PDT of oral cancer and leukoplakia cells
Authors: Zhang Ying , Ye Sai , Zhou Yongmei , Zhou Zengtong , Yao Yilin , Liu Wei , Wu Lan 
Published: January 2023

AbstractBackgroundPhotodynamic therapy (PDT) relies on the light activation of a photosensitizers to generate reactive oxygen species such as singlet oxygen, but its effect on cancer therapy is limited dramatically by hypoxia in the tumor microenvironment.ObjectivesTo determine the potential of a nano‐photosensitizer loaded salvianolic acid B (SalB) and 5‐aminolevulinic acid (ALA) for enhancing the efficacy of PDT in oral squamous cell carcinoma Cal27 cells and leukoplakia Leuk1 cells.ResultsSinglet oxygen sensor green (SOSG) assay showed that nano‐SalB‐ALA generated higher levels of singlet oxygen, compared to nano‐SalB and nano‐ALA. Cellular uptake assay showed that nano‐SalB‐ALA effectively absorbed by Leuk1 cells. Importantly, cell counting kit‐8 and flow cytometry revealed that PDT with nano‐SalB‐ALA effectively inhibited the viability and induced the apoptosis of Cal27 and Leuk1 cells, respectively. Moreover, the tumor xenograft study revealed that PDT with nano‐SalB‐ALA had a stronger inhibitory effect on tumor growth of nude mice, compared to control groups.ConclusionsThe novel photosensitizer nano‐SalB‐ALA remarkably enhanced the efficacy of PDT by improving singlet oxygen production, inhibiting cell proliferation, promoting cell apoptosis, and suppressing tumor growth. These suggest PDT with nano‐SalB‐ALA could be a clinically significant and potent treatment for oral cancer and leukoplakia.
Assessing the suitability of stress tolerant early‐maturing maize (Zea mays) inbred lines for hybrid development using combining ability effects and DArTseq markers
Authors: Adewale Samuel A. , Badu‐Apraku Baffour , Akinwale Richard O. 
Published: January 2023

AbstractIdentification of hybrids for commercialization is crucial for sustainable maize production in sub‐Saharan Africa (SSA). One hundred and ninety test crosses, 10 tester × tester crosses + 10 hybrid checks were evaluated across 11 environments, 2017 to 2019. Inheritance of grain yield under Striga infestation, optimal and across environments was influenced by additive genetic action, but there was greater influence of nonadditive gene action under drought stress conditions. Nine, seven and two inbreds had significant and positive general combining ability (GCA) effects for grain yield under Striga‐infested, optimal and drought stress environments, respectively, and would contribute high grain yield to their progenies. Heterotic grouping methods based on specific and GCA, GCA effects of multiple traits and DArTseq markers classified the inbreds into five, three and two heterotic groups, respectively, across research conditions. The DArTseq markers method that classified the inbred lines into two major heterotic groups and was one of the most efficient methods should be adopted for practical purposes in maize breeding programmes in SSA. Hybrids TZEI 7 × TZdEI 352, TZEI 1238 × TZEI 7 and TZEI 1252 × TZEI 7 had outstanding grain yield under contrasting environments and should be tested on‐farm for commercialization in SSA.
Follow up of renal outcomes in children with solitary kidney
Authors: Akyol Onder Esra Nagehan , Yilmaz Omer , Taneli Can , Ertan Pelin 
Published: January 2023

AbstractBackgroundSolitary kidney (SK) affects 1/1000 people worldwide, and there are controversies concerning renal outcomes in these patients. This study aimed to investigate clinical findings and renal outcomes in children with SK and to compare the results for congenital (CSK) and acquired SK (ASK) groups.MethodsThe study included patients that presented to our pediatric nephrology department with SK between January 2010 and January 2021. Demographic and clinical data were recorded retrospectively.ResultsOf the 101 patients with SK, 71 had CSK (55 had unilateral renal agenesis and 16 had a multicystic dysplastic kidney) and 30 had ASK (17 had previously undergone unilateral nephrectomy due to a renal tumor and 13 had urological structural anomalies). There were nine patients (9%) with renal injury. The serum uric acid level was significantly higher and the estimated glomerular filtration rate was significantly lower in the patients with ASK compared with those with CSK (p = 0.005 and p < 0.001, respectively). There was a positive correlation between renal injury and the uric acid level (p < 0.001, r = 0.45).ConclusionIn addition to the management of blood pressure and proteinuria, it is important to control uric acid levels in patients with SK, especially those with ASK, to prevent renal injury. The ASK group has a greater risk of renal injury than the CSK group. There is a need for new markers to predict early stage renal damage in SK.
Inborn errors of bile acid metabolism in Japan
Authors: Mizuochi Tatsuki , Takei Hajime , Nittono Hiroshi , Kimura Akihiko 
Published: January 2023

AbstractBile acids are a category of steroids biosynthesized from cholesterol in the liver. Inborn errors of their metabolism are inherited in an autosomal recessive manner, resulting in enzyme deficiencies affecting the bile acid biosynthetic pathway. These defects in the pathway cause accumulation of unusual bile acids or bile alcohols. Unusual bile acids are highly cytotoxic, causing injury to the liver. These unusual bile acids damage hepatocytes, resulting in cholestatic liver injury beginning in infancy. Except for cerebrotendinous xanthomatosis and some secondary defects, various inborn errors of bile acid metabolism (IEBAM) have been reported from Japan, affecting eight patients including three with 3β‐hydroxy‐Δ5‐C27‐steroid dehydrogenase/isomerase deficiency, three with Δ4‐3‐oxosteroid 5β‐reductase deficiency, one with oxysterol 7α‐hydroxylase deficiency, and one with bile acid‐CoA: amino acid N‐acyltransferase deficiency. Distinctive laboratory findings in patients with 3β‐hydroxy‐Δ5‐C27‐steroid dehydrogenase/isomerase deficiency, Δ4‐3‐oxosteroid 5β‐reductase deficiency, and oxysterol 7α‐hydroxylase deficiency include normal serum γ‐glutamyltransferase and total bile acids concentrations despite presence of cholestasis (elevated serum direct bilirubin) from infancy. Pediatricians and pediatric surgeons who suspect a case of IEBAM should obtain urinary and serum bile acid analyses using gas or liquid chromatography‐mass spectrometry as well as genetic analyses. Available treatments include oral cholic acid, chenodeoxycholic acid, glycocholic acid, and ursodeoxycholic acid; fat‐soluble vitamin supplementation; and liver transplantation. Early diagnosis and treatment can offer a good outcome.
Asymptotic distribution of the eigenvalues of the bending‐torsion vibration model with fully nondissipative boundary feedback
Authors: Shubov Marianna A. , Kindrat Laszlo P. 
Published: January 2023

AbstractAsymptotic and spectral results on the initial boundary‐value problem for the coupled bending‐torsion vibration model (which is important in such areas of engineering sciences as bridge and tall building designs, aerospace and oil pipes modeling, etc.) are presented. The model is given by a system of two hyperbolic partial differential equations equipped with a three‐parameter family of non‐self‐adjoint (linear feedback type) boundary conditions modeling the actions of self‐straining actuators. The system is rewritten in the form of the first‐order evolution equation in a Hilbert space of a four‐component Cauchy data. It is shown that the dynamics generator is a matrix differential operator with compact resolvent, whose discrete spectrum splits asymptotically into two disjoint subsets called the α‐branch and the β‐branch, respectively. Precise spectral asymptotics for the eigenvalues from each branch as the number of an eigenvalue tends to ∞ have been derived. It is also shown that the leading asymptotical term of the α‐branch eigenvalue depends only on the torsion control parameter, while of the β‐branch eigenvalue depends on two bending control parameters.
‘Values‐based Territorial Food Networks’—Benefits, challenges and controversies
Authors: Nemes Gusztáv , Reckinger Rachel , Lajos Veronika , Zollet Simona 
Published: January 2023

AbstractThe special issue titled ‘Values‐based Territorial Food Networks – Benefits, challenges and controversies’ and this introductory editorial aim to bridge conceptual and disciplinary differences within the literature on alternative agro‐food networks and related concepts. In the editorial we outline a new umbrella term, Values‐based Territorial Food Networks (VTFNs), which synthesises the key commonalities that characterise alternatives to the mainstream food system (see Reckinger 2022 for a more detailed analysis). VTFNs are defined as networks that connect agro‐food and related stakeholders within a defined territory that operate according to a coherent set of ethical values centred on social justice and wellbeing, environmental integrity, participatory governance and economic fairness. We discuss how VTFNs relate to earlier concepts, showing the evolution from ‘alternative’ to ‘values based’, from ‘local’ to ‘territorial’ and from ‘supply chains’ to ‘networks’. The editorial also gives an overview of the empirical case studies in the special issue, which explore 10 place‐based food initiatives (from Austria, France, Greece, Germany, The Netherlands, Sweden, Norway, Hungary, Australia, Brazil and Japan) and address benefits, challenges, social learning and controversies associated with VTFNs. The cases are grouped into three thematic areas. ‘Social learning and resilience’ focuses on collaboration through diverse partnerships as a necessary condition for social innovation and for understanding new socio‐technical practices. ‘Agency, negotiations and food governance’ explores the socioeconomic struggles, interrelations and negotiated values associated with VTFNs. ‘Sociocultural environments, social capital and reflexive localism’ discusses the interplay between the economic and sociocultural dimensions related to VTFNs. The transversality of VTFN allows us to think about these dimensions from a systemic perspective, thus advancing debates on the diverse sites and modes of agro‐food sustainability.
Early administration of SARS‐CoV‐2 monoclonal antibody reduces the risk of mortality in hematologic malignancy and hematopoietic cell transplant patients with COVID‐19
Authors: Jabr Ra'ed , Khatri Akshay , Anderson Anthony D. , Garcia Leopoldo Cordova , Viotti Julia Bini , Natori Yoichiro , Raja Mohammed , Camargo Jose F. , Morris Michele I. 
Published: January 2023

AbstractBackgroundData on severe acute respiratory distress syndrome coronavirus 2 monoclonal antibody (SARS‐CoV‐2‐specific mAb) use in hematologic malignancy and hematopoietic cell transplantation (HM/HCT) patients are limited. Here, we describe our experience with the use of casirivimab–imdevimab or bamlanivimab for the treatment of coronavirus disease 2019 (COVID‐19) in HM/HCT patients.MethodsThis was a retrospective chart review at the University of Miami Hospital and Sylvester Comprehensive Cancer Center for HM/HCT patients with COVID‐19 who received casirivimab–imdevimab or bamlanivimab from November 21, 2020, to September 30, 2021. Outcomes measured were mortality, hospital admission, and infusion reaction to SARS‐CoV‐2‐specific mAbs.ResultsWe identified 59 HM/HCT patients with mild to moderate COVID‐19 who received casirivimab–imdevimab or bamlanivimab. Median age was 57 years (interquartile range [IQR]: 45–65). Among the 59 patients, 25 (42%) received cellular therapy: 14 (24%) had undergone allogeneic HCT, nine (15%) autologous HCT, and two (3%) received chimeric antigen receptor T‐cell therapy. The median time from COVID‐19 symptom onset to SARS‐CoV‐2‐specific mAb administration was 4 (IQR: 3–6) days. Forty‐six (78%) patients received SARS‐CoV‐2‐specific mAbs as outpatients and 13 (22%) patients received SARS‐CoV‐2‐specific mAbs during hospitalization. Among patients who received SARS‐CoV‐2‐specific mAbs as outpatients, only four (9%) visited the emergency department at days 10, 11, 15, and 35 after SARS‐CoV‐2‐specific mAb administration. None of these four patients required hospital admission. Among the hospitalized patients, five (38%) were admitted to the hospital with neutropenic fever, four (31%) were already hospitalized for transplantation and cellular therapy, three (23%) were admitted for monitoring of COVID‐19 symptoms, and one (8%) was admitted with acute kidney injury. Three hospitalized patients (23%) died at 14, 35, and 59 days after SARS‐CoV‐2‐specific mAb administration; two of these three deaths were attributed to COVID‐19 infection. One patient developed an immediate infusion reaction to bamlanivimab, and no infusion reactions were reported to casirivimab–imdevimab use.ConclusionDuring the alpha and delta variant surges, early administration of bamlanivimab or casirivimab–imdevimab prevented hospitalization and death when given in the outpatient setting. Among patients who received mAbs at or after hospital admission, the risk of COVID‐19 disease progression and death remains significant. Larger studies of the use of mAb therapy to treat COVID‐19 in this population are needed.
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Reviewer Acknowledgements for Business and Management Studies, Vol. 8, No. 2
Authors: Willianms Ellery 
Published: January 2023

Business and Management Studies (BMS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether BMS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 8, Number 2Abdul-Kahar Adam, University of Education, GhanaChrister Thörnqvist, University of Skövde , SwedenFábio Albergaria de Queiroz, Catholic University of Brasília, BrazilJennilyn Castillo Mina, Nueva Ecija University of Science and Technology, PhilippinesLucie Andreisová, University of Economics in Prague, CzechMarica Ion Dumitrasco, Academy of Sciences of Moldova, Moldova