bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury
Authors: Tian Ming-yue , Yang Yi-duo , Qin Wan-ting , Liu Bao-nian , Mou Fang-fang , Zhu Jing , Guo Hai-dong , Shao Shui-jin 
Published: September 2023

AbstractAlthough the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism remains incompletely elucidated. In our study, we observed that EA intervention led to a reduction in the expression of the long non-coding RNA growth-arrest-specific transcript 5 (GAS5) and an increased in miR-21 levels within the injured nerve, effectively promoting functional recovery and nerve regeneration following sciatic nerve injury (SNI). In contrast, administration of adeno-associated virus expressing GAS5 (AAV-GAS5) weakened the therapeutic effect of EA. On the other hand, both silencing GAS5 and introducing a miR-21 mimic prominently enhanced the proliferation activity and migration ability of Schwann cells (SCs), while also inhibiting SCs apoptosis. On the contrary, inhibition of SCs apoptosis was found to be mediated by miR-21. Additionally, overexpression of GAS5 counteracted the effects of the miR-21 mimic on SCs. Moreover, SCs that transfected with the miR-21 mimic promoted neurite growth in hypoxia/reoxygenation-induced neurons, which might be prevented by overexpressing GAS5. Furthermore, GAS5 was found to be widely distributed in the cytoplasm and was negatively regulated by miR-21. Consequently, the targeting of GAS5 by miR-21 represents a potential mechanism through which EA enhances reinnervation and functional restoration following SNI. Mechanistically, the GAS5/miR-21 axis can modulate the proliferation, migration, and apoptosis of SCs while potentially influencing the neurite growth of neurons.
The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2
Authors: Gu Miao , Li Xiaodi , Wu Ronghua , Cheng Xiao , Zhou Songlin , Gu Xiaosong 
Published: September 2023

AbstractTranscription factors are essential for the development and regeneration of the nervous system. The current study investigated key regulatory transcription factors in rat spinal cord development via RNA sequencing. The hub gene Ets1 was highly expressed in the spinal cord during the embryonic period, and then its expression decreased during spinal cord development. Knockdown of Ets1 significantly increased the axonal growth of cultured spinal cord neurons. Luciferase reporter assays and chromatin immunoprecipitation assays indicated that Ets1 could directly bind to the Lcn2 promoter and positively regulate Lcn2 transcription. In conclusion, these findings provide the first direct evidence that Ets1 regulates axon growth by controlling Lcn2 expression, and Ets1 may be a novel therapeutic target for axon regeneration in the central nervous system.
A multi-objective flexible manufacturing system design optimization using a hybrid response surface methodology
Authors: Pasha Nima , Amoozad Mahdiraji Hannan , Razavi Hajiagha Seyed Hossein , Garza-Reyes Jose Arturo , Joshi Rohit 
Published: September 2023

AbstractThe present study proposes a hybrid framework combining multiple methods to determine the optimal values of design variables in a flexible manufacturing system (FMS). The framework uses a multi-objective response surface methodology (RSM) to achieve optimum performance. The performance of an FMS is characterized using various weighted measures using the best–worst method (BWM). Subsequently, an RSM approximates the functional relationship between the FMS performance and design variables. The central composite design (CCD) is used for this aim, and a polynomial regression model is fitted among the factors. Eventually, a bi-objective model, including the fitted and cost functions, is formulated and solved. As a result, the optimal percentage for deploying the FMS equipment and machines to achieve optimal performance with the lowest deployment cost is determined. The proposed framework can serve as a guideline for manufacturing organizations to lead strategic decisions regarding the design problems of FMSs. It significantly increases productivity for the manufacturing system, reduces redundant labor and material handling costs, and facilitates production.
A genetic profiling guideline to support diagnosis and clinical management of lymphomas
Authors: Sánchez-Beato Margarita , Méndez Miriam , Guirado María , Pedrosa Lucía , Sequero Silvia , Yanguas-Casás Natalia , de la Cruz-Merino Luis , Gálvez Laura , Llanos Marta , García Juan Fernando , Provencio Mariano 
Published: September 2023

AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas. Multiple studies have identified genetic markers that improve diagnostics and prognostication, and next-generation sequencing is becoming an essential tool in the clinical laboratory. This review provides a “next-generation sequencing” guide for lymphomas. It discusses the genetic alterations of the most frequent mature lymphoma entities with diagnostic, prognostic, and predictive potential and proposes targeted sequencing panels to detect mutations and copy-number alterations for B- and NK/T-cell lymphomas.
Aggressive Mimicry and the Evolution of the Human Cognitive Niche
Authors: Moser Cody , Buckner William , Sarian Melina , Winking Jeffrey 
Published: September 2023

AbstractThe evolutionary origins of deception and its functional role in our species is a major focus of research in the science of human origins. Several hypotheses have been proposed for its evolution, often packaged under either the Social Brain Hypothesis, which emphasizes the role that the evolution of our social systems may have played in scaffolding our cognitive traits, and the Foraging Brain Hypothesis, which emphasizes how changes in the human dietary niche were met with subsequent changes in cognition to facilitate foraging of difficult-to-acquire foods. Despite substantive overlap, these hypotheses are often presented as competing schools of thought, and there have been few explicitly proposed theoretical links unifying the two. Utilizing cross-cultural data gathered from the Human Relations Area Files (HRAF), we identify numerous (n = 357) examples of the application of deception toward prey across 145 cultures. By comparing similar behaviors in nonhuman animals that utilize a hunting strategy known as aggressive mimicry, we suggest a potential pathway through which the evolution of deception may have taken place. Rather than deception evolving as a tactic for deceiving conspecifics, we suggest social applications of deception in humans could have evolved from an original context of directing these behaviors toward prey. We discuss this framework with regard to the evolution of other mental traits, including language, Theory of Mind, and empathy.
Psychometric properties of the Spanish adaptation of the Mental Health Continuum—Short Form: A bifactor ESEM approach in an adolescent sample
Authors: Tejada-Gallardo Claudia , Blasco-Belled Ana , Alsinet Carles 
Published: September 2023

AbstractThe mental health continuum—short form (MHC-SF) is a measure that has been increasingly used to assess the positive mental health of the general population. Past research has revealed that the exploratory structural equation modeling (ESEM) technique yielded the best results for exploring the factorial structure of this measure. However, this technique has not been applied to the Spanish adaptation of the MHC-SF in adolescents. The present study aims for an in-depth examination of the structure of this scale in a population of Spanish adolescents (n = 465) by implementing ESEM. Different competing models were tested using confirmatory factor analysis (CFA) and ESEM. Measurement invariance, internal reliability, and construct validity were also assessed (n = 382). The findings favored the bifactor ESEM model over the commonly used three-factor structure and the bifactor CFA. The general positive mental health factor was reliable and supported convergent and discriminant validity. The findings confirm that the MHC-SF in a Spanish adolescent sample is best represented by combining the bifactor structure with a general positive mental health factor and ESEM. This study considers the implications derived from implementing this model.
The relationship between dark tetrad and conspiracy beliefs. No consistent results across three different samples from Slovakia
Authors: Teličák Peter , Halama Peter , Kohút Michal 
Published: September 2023

AbstractThe present study focused on whether Dark Tetrad characteristics (machiavellianism, narcissism, psychopathy, and sadism) predict conspiracy beliefs (COVID-19 related and general) in the Slovak population. Three independent samples were used for the study. The first sample consisted of 804 (73.9% women) university students of the middle-sized Slovak university. The second sample consisted of 489 (61.2% women) Facebook users. The third group was recruited from an online panel of a research agency and included 600 respondents (49% women). The results provided different findings for the three research samples. Results showed that machiavellianism was a positive predictor of conspiracy beliefs (COVID-19 and general) among respondents from a research agency and a university (general only). Psychopathy positively predicted COVID-19 and general conspiracy beliefs only among respondents from the Facebook sample. Narcissism positively predicted COVID-19 conspiracy beliefs among university students. The results of the study suggest that there is no consistent pattern of relationship between Dark Tetrad and conspiracy beliefs across different samples in Slovakia. Future research should focus on whether these inconsistencies are due to sample characteristics or they express lack of stable relationships between these two psychological variables.
Are advertising campaigns for water conservation in Latin America persuasive? A mixed-method approach
Authors: Sánchez Carolina , Bianchi Enrique Carlos , Rodriguez-Sanchez Carla , Sancho-Esper Franco 
Published: September 2023

AbstractThe United Nations 2030 Agenda for Sustainable Development calls for an urgent reduction of global water footprint. Communication is crucial to respond to this call. However, most water conservation communication campaigns use the knowledge deficit model and overlook persuasive techniques. This paper presents a mixed-method approach consisting of exploratory sequential qualitative (content) analysis followed by a quantitative (cluster) analysis. This approach was used to explore the communication strategies of 95 advertisements promoting water conservation in Latin America. Four widely used persuasion frameworks were analyzed: (1) the elaboration likelihood model (ELM), (2) prospect theory (gains vs. losses), (3) the action framework (i.e., do more vs. take less), and (4) the temporal distance frame. Regarding persuasive characteristics (ELM model), most ads excluded behavioral beneficiaries (58%) and included explicit (60%) and active (52%) messages. Virtually all ads (87%) had a denotative message. Surprisingly, only 3% and 43% of ads used social norms and an authority source, respectively. Regarding the communication strategy, 44% of ads used a loss frame, and 59% focused on the current generation. Cluster analysis was used to classify the sample of ads into homogeneous groups. This analysis leads to a better understanding of the profile of campaigns promoting water conservation. Four advertising profiles were identified: (1) Persuade to act (29%), (2) Motivate without scaring (35%), (3) Raise awareness of water problems (19%), and (4) Warn of water problems (17%). The paper offers a discussion of the implications for social marketers and directions for future research on how to design effective communication campaigns.
The Biosynthesis of Proteins for Nano Engines as a Normative Process
Authors: Beekman Wim , Jochemsen Henk 
Published: September 2023

AbstractIn this article two questions are discussed with regard to semiosis in protein biosynthesis for nano engines. (1) What kind of semiosis is involved in the construction of these proteins? and (2) How can we explain the semiotic process observed? With regard to the first issue we draw attention to comparisons between semiosis in protein biosynthesis and human natural language. The notion of normativity appears to be of great importance for both. A comparison also demonstrates differences. Nevertheless, because of the normative symbolic information processing in it, we suggest to employ the term symbolic reference (employed in linguistics as a distinguishing feature of human language) to indicate the semiotic processes in protein biosynthesis. With regard to explaining semiosis in protein synthesis we compare different approaches. We conclude that a Kantian approach should be preferred. In such an approach strengths of the mechanistic and organicist approaches can be combined, and the observed symbolic information processing acknowledged.
Impact of Practical Online Lessons on Chinese Medical Students’ Perception of Radiation Oncology
Authors: Zheng Ziye , Wang Yuxuan , Zhang Fuquan , Zhu Jiawei , Shen Jing , Meng Qingyu , Wang Bei , Zhou Bing , Tian Wei , Yu Lihua , Yan Junfang 
Published: September 2023

AbstractRadiotherapy is an essential component of oncology treatment. It is imperative that clinicians and medical students have a fundamental understanding of radiotherapy. However, radiation oncology education is deficient worldwide. This study introduced an hour-long online Massive Open Online Course (MOOC) as a supplement to the basic curriculum for 8-year medical students at Peking Union Medical College and Tsinghua University in China. The students’ personal opinions and comprehension of radiation oncology therapy were assessed through pre- and post-test questionnaires before and after the MOOC study. The results indicated that the percentage of students interested in radiotherapy increased, and their knowledge of radiotherapy significantly improved after the online MOOC study, suggesting that short-term MOOC study may stimulate students’ interest in learning and improving their knowledge of radiation therapy. The study suggests that the combination of online and offline teaching may be a feasible way to develop radiation oncology education in the future.
The Art of Prophesy: Selection for English-Medium Undergraduate Initial Teacher Education Programmes in New Zealand
Authors: Trevethan Helen 
Published: September 2023

AbstractI offer this critical essay as a reminder of the prevalence of unproven negative dialogue about Initial Teacher Education (ITE) in New Zealand, taking selection practices as an example. The focus of this critical essay is the evidence base about selection of students into English-medium undergraduate ITE programmes. In New Zealand and elsewhere, selection practices suggest that there are some people who are suited to teaching and others who are not and that we can, and should, screen out unsuitable people before entry. I make a case for examining taken-for-granted assumptions about selection and developing research informed selection practices in response to calls for increased diversity in the profession.
Normalized closeness centrality of urban networks: impact of the location of the catchment area and evaluation based on an idealized network
Authors: Chen Hsiao-Hui , Dietrich Udo 
Published: September 2023

AbstractThe decision of where to locate the catchment area of an urban network exerts significant influence on the indicator values and in this research this influence is referred to as the placement effect. Placement effect has significant impact on the studies at the neighborhood scale focusing on the structural properties of the network models, the network analysis results and centrality measures, the inferred movement patterns and the accessibility to destination. Placement effect becomes even more significant when multiple catchment areas are sampled to be compared or classified. This research examines placement effect on one of the most affected indicators, closeness centrality, and proposes using an idealized network as a reference to be compared with the real network in order to find a solution to mitigate the placement effects. By comparing the normalized closeness centrality in the real network with that in the idealized network, we can (1) evaluate the placement effect on the closeness centrality and (2) find the threshold distance in order to mitigate the placement effect. The results show that the closeness centrality of the same node varies remarkably depending on its position and how central it is in the chosen catchment area. Specifically, in the selected areas in this research, if the center point of a catchment area is moved by more than 100 m away from the original center point, the closeness centrality of the same node starts to be significantly influenced by the placement effect. The threshold distance of 100 m offers a recommendation that a direct comparison of the closeness centrality between different nodes in the same catchment area should be drawn only if these nodes are less than 100 m away from each other. In other words, when comparing two nodes located further than the threshold distance from each other, it is advisable to create two separate catchment areas, where these nodes serve as the center points. It should be noted that the threshold distance of 100 m derived specifically from the current research should not be generalized to other cases. The threshold distance of different case studies remains open for further investigation in the future as it may vary among cities or areas.
Affective Science Research: Perspectives and Priorities from the National Institutes of Health
Authors: Simmons Janine M. , Breeden Andrew , Ferrer Rebecca A. , Gillman Arielle S. , Moore Holly , Green Paige , Pariyadath Vani , Quinlan Erin B. , Vicentic Aleksandra 
Published: September 2023

AbstractAffective science is a broad and burgeoning field, and the National Institutes of Health (NIH) support research on a similarly broad range of topics. Across NIH, funding is available for basic, translational, and intervention research, including research in non-human animals, healthy populations, and those with or at risk for disease. Multiple NIH Institutes and Centers have specific programs devoted to topics within the affective science umbrella. Here, we introduce the funding priorities of these six: the National Cancer Institute (NCI), National Center for Complementary and Integrative Health (NCCIH), National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute on Drug Abuse (NIDA), and National Institute on Minority Health and Health Disparities (NIMHD). We then discuss overlapping themes and offer a perspective on promising research directions.
Relationships of Body Dissatisfaction and Self-Esteem with Social Physique Anxiety among University Students in Different Study Programs
Authors: Tsartsapakis Ioannis , Zafeiroudi Aglaia , Vanna Glafki , Gerou Maria 
Published: September 2023

AbstractThe purpose of this study was to investigate the relationships of body dissatisfaction and self-esteem with social physique anxiety in students pursuing different subjects of study. A total of 219 students aged 22 ± 1.9 years of age participated; 78 were men and 141 women. The participants were divided into two groups according their subject of study. Group A consisted of 123 (56.2%) students in the Department of Physical Education & Sport Science, whose studies were directly associated with the body and physical appearance. Group B consisted of 96 (43.8%) students in other departments. All participants completed the scales: (a) Social Physique Anxiety, (b) Body Dissatisfaction and (c) Self-Esteem. Correlation analysis indicated positive significant values between social physique anxiety, body dissatisfaction and body mass index, and a negative significant correlation between social physique anxiety and self-esteem. Stepwise multiple linear regression analysis with social physique anxiety as a dependent variable across the sample and in group A revealed that social physique anxiety was significantly positively predicted by body dissatisfaction and significantly negatively predicted by self-esteem. For group B, social physique anxiety was significantly positively predicted by only body dissatisfaction. T test analysis indicated significant differences in body dissatisfaction, with group B scoring higher than group A. The results are discussed in the context of practical applications to address symptoms of social physique anxiety regarding body construction in young adults and to provide regular exercise support in study programs at universities.
Statin adherence in patients enrolled in the disease management program for coronary artery disease – comparison between patients’ and general practitioners’ self-reports and patient records
Authors: Salam Babak , Schrimpf Anne , Münster Sebastian , Bleckwenn Markus 
Published: September 2023

Abstract
Introduction
Patients with coronary artery disease (CAD) should take a statin daily for secondary prevention. However, statin adherence in patients with CAD is low. This study investigated the proportion of adherent patients enrolled in the disease management program for CAD (DMP-CAD). Adherence was examined by comparing patients’ self-reports, general practitioners’ (GPs) self-reports, and prescription data.

Methods
Between October 2019 and March 2020, all patients enrolled in the DMP-CAD in three GP practices in Germany were invited to participate in the study. Participants completed a questionnaire on the tolerability of statins. Further, prescription data from patient records, low-density lipoprotein (LDL) levels, and GPs’ assessment of statin adherence were examined. The Medication Possession Ratio (MPR) served as a measurement tool for adherence.

Results
Seventy-four patients were included. MPR showed high statin adherence for most patients (83.8%). However, GPs did not reliably identify non-adherence in their patients. Generally, the mean LDL values were above the guideline recommendations (97.7 ± 27.9 mg/dl), with higher values in the non-adherent (123.6 ± 42 mg/dl) than in the adherent group (93.1 ± 22 mg/dl). Non-adherent patients were more likely to be employed (41.7% vs. 11.3%).

Discussion
Patients in this study showed high statin adherence. However, the LDL target value was often not reached. Therefore, GPs should take advantage of the good adherence of their patients and try to lower LDL levels by adjusting the dosage and/or changing the statin prescribed. Future studies should investigate typical characteristics of non-adherent patients in DMP-CAD so that GPs can target these patient groups and improve their adherence.