bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural optimization to improve the dynamic performance of novel co‐curing damping sandwich composites
Authors: Zheng Changsheng , Sun Pingping , Fu Yanping , Fu Xiaojing , Li Qiang 
Published: January 2023

AbstractCo‐cured damping composite structures have broad application prospects in high‐tech fields such as aerospace and space vehicles because of their low weight, large damping, and sufficient stiffness. In order to improve dynamic properties of conventional composite structures, a new type of damping composites embedded with multilayer viscoelastic film is proposed in this paper. Based on the complex modulus theory and vibration mechanics of composite plates and shells, vibration differential equation of composite plates with multilayer viscoelastic film is derived. The constitutive relation of the complex structure is established. The consistency of theoretical derivation and numerical simulation results provides a reference for the optimization of dynamic performance of damping sandwich composites. The effects of the distribution of viscoelastic film and the geometric structure parameters on dynamic performance of co‐cured damping composites are also discussed. The results show that the embedding of multi‐layer viscoelastic film can greatly enhance the loss factors of co‐cured composite structures under same damping layer thickness. This work lays a foundation for optimization of dynamic performance of lightweight and large damping composite structures.
Rapid quality evaluation of four kinds of Polygoni Multiflori Radix Praeparata by electronic eye combined with chemometrics
Authors: Zhang Peng , Xu Yudi , Qu Fanna , Zhou Ping , Zhang Jing , Bi Xueyan , Xiao Yongqing , Liu Ying 
Published: January 2023

AbstractIntroductionPolygonum multiflorum Thunb., a widely used herbal medicine, has trouble with the hepatic adverse effect. Processing is an effective method to increase potency and reduce the adverse effects of herbal medicines. Polygoni Multiflori Radix Praeparata (PMRP), the decoction pieces processed from raw material, is widely consumed in clinical practice in many countries. The quality control of PMRP has attracted more and more attention worldwide.ObjectiveA simple and rapid quality evaluation method using an electronic eye (E‐eye) combined with chemometrics was proposed for controlling the quality of PMRP.Materials and methodsThe semi‐quantitative and quantitative data of 105 major components in 128 batches of PMRP samples obtained by three different analysis instruments were fused to investigate the correlation with the dynamic exterior colour determined by E‐eye. The correlation between exterior colour and chemical fusion dataset was investigated by orthogonal partial least squares discriminant analysis (OPLS‐DA) and partial least squares regression (PLSR). According to the results of correlation analysis, the color parameters of high‐quality PMRP was set.ResultsCorrelation studies by chemometrics revealed that the exterior colour depth was significantly correlated with 32 components [variable importance in the projection (VIP) > 1.0, p < 0.05]. The colour parameter of
located in the range of 46.69–51.66 can be used easily, rapidly, and in an environment‐friendly way to determine whether the PMRP sample has reached sufficient processing time with good quality.ConclusionThis study adds some scientific information to our understanding of traditional medicine while contributing an alternative method for assessing the quality of other decoction pieces.
Critical insights into ethylene‐1‐alkene copolymers and long‐chain branched polyethylene microstructure on thermo‐rheological and sealing behavior of multicomponent systems
Authors: Galgali Girish , Kaliappan Senthil Kumar , De Santis Felice 
Published: January 2023

AbstractThe microstructure‐property relationships in multicomponent ethylene‐1‐alkene copolymers with different branching in the microstructures are demonstrated. The metallocene catalyzed linear low density polyethylene (mLLDPE), was miscible with both autoclave grade low density polyethylene (LDPE‐A) and/or tubular grade low density polyethylene (LDPE‐T). For these multicomponent systems, the rheological response was distinctly differentiating and sensitive to the microstructure of LDPE, at higher shear regimes. The thicker lamellae of LDPE‐T and/or LDPE‐A might co‐crystallize if there is a high density polyethylene‐like fraction present in the mLLDPE. Even though the macro parameters like density and melt index (MI) of the investigated multicomponent systems are comparable, the subtle differences in the microstructure manifested by type and distribution of comonomer and/or branching affected the sealing performance. Both high comonomer content and comonomer distribution in the mLLDPE matrix affording a higher fraction of material melting below 120°C were found to be critical for the heat sealing. The fraction of material melting at lower temperatures, attributed to the tertiary branches present in the hyper‐branched microstructure of LDPE‐A, participate in the sealing process, and lower the sealing temperature. It was evident that mLLDPE with asymmetric distribution of lamellae is more sensitive to the microstructure of the LDPE used.
Engineering excitonically coupled dimers in an artificial protein for light harvesting via computational modeling
Authors: Curti Mariano , Maffeis Valentin , Teixeira Alves Duarte Luís Gustavo , Shareef Saeed , Hallado Luisa Xiomara , Curutchet Carles , Romero Elisabet 
Published: January 2023

AbstractIn photosynthesis, pigment–protein complexes achieve outstanding photoinduced charge separation efficiencies through a set of strategies in which excited states delocalization over multiple pigments (“excitons”) and charge‐transfer states play key roles. These concepts, and their implementation in bioinspired artificial systems, are attracting increasing attention due to the vast potential that could be tapped by realizing efficient photochemical reactions. In particular, de novo designed proteins provide a diverse structural toolbox that can be used to manipulate the geometric and electronic properties of bound chromophore molecules. However, achieving excitonic and charge‐transfer states requires closely spaced chromophores, a non‐trivial aspect since a strong binding with the protein matrix needs to be maintained. Here, we show how a general‐purpose artificial protein can be optimized via molecular dynamics simulations to improve its binding capacity of a chlorophyll derivative, achieving complexes in which chromophores form two closely spaced and strongly interacting dimers. Based on spectroscopy results and computational modeling, we demonstrate each dimer is excitonically coupled, and propose they display signatures of charge‐transfer state mixing. This work could open new avenues for the rational design of chromophore–protein complexes with advanced functionalities.
Partial mimicry of the microtubule binding of tau by its membrane binding
Authors: MacAinsh Matthew , Zhou Huan‐Xiang 
Published: January 2023

AbstractTau, as typical of intrinsically disordered proteins (IDPs), binds to multiple targets including microtubules and acidic membranes. The latter two surfaces are both highly negatively charged, raising the prospect of mimicry in their binding by tau. The tau‐microtubule complex was recently determined by cryo‐electron microscopy. Here, we used molecular dynamics simulations to characterize the dynamic binding of tau K19 to an acidic membrane. This IDP can be divided into three repeats, each containing an amphipathic helix. The three amphipathic helices, along with flanking residues, tether the protein to the membrane interface. The separation between and membrane positioning of the amphipathic helices in the simulations are validated by published EPR data. The membrane contact probabilities of individual residues in tau show both similarities to and distinctions from native contacts with microtubules. In particular, a Lys that is conserved among the repeats forms similar interactions with membranes and with microtubules, as does a conserved Val. This partial mimicry facilitates both the membrane anchoring of microtubules by tau and the transfer of tau from membranes to microtubules.
Californian thistle (Cirsium arvense): endophytes and Puccinia punctiformis
Authors: Kentjens Wendy , Casonato Seona , Kaiser Clive 
Published: January 2023

AbstractCalifornian thistle (Cirisum arvense) is a troublesome weed in pastures and cropping systems. The fungal biocontrol agent Puccinia punctiformis, commonly referred to as thistle rust, performs inconsistently on C. arvense. Problems with P. punctiformis establishment and control of C. arvense may be attributable to differing plant endophytic populations in various environments. This article provides an overview of the relationships between endophytes and their host, but also between endophytes and pathogens with a focus on rust pathogens. This review provides insights into reasons why P. punctiformis performs inconsistently and identifies gaps in our knowledge. Filling these gaps may help to improve performance of this classical fungal biocontrol agent. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species
Authors: Cordes Henrik , Rapp Hermann 
Published: January 2023

AbstractIn drug research, developing a sound understanding of the key mechanistic drivers of pharmacokinetics (PK) for new molecular entities is essential for human PK and dose predictions. Here, characterizing the absorption, distribution, metabolism, and excretion (ADME) processes is crucial for a mechanistic understanding of the drug–target and drug–body interactions. Sufficient knowledge on ADME processes enables reliable interspecies and human PK estimations beyond allometric scaling. The physiologically based PK (PBPK) modeling framework allows the explicit consideration of organ‐specific ADME processes. The sum of all passive and active ADME processes results in the observed plasma PK. Gene expression information can be used as surrogate for protein abundance and activity within PBPK models. The absolute and relative expression of ADME genes can differ between species and strains. This is affecting both, the PK and pharmacodynamics and is therefore posing a challenge for the extrapolation from preclinical findings to humans. We developed an automated workflow that generates whole‐body gene expression databases for humans and other species relevant in drug development, animal health, nutritional sciences, and toxicology. Solely, bulk RNA‐seq data curated and provided by the Swiss Institute of Bioinformatics from healthy, normal, and untreated primary tissue samples were considered as an unbiased reference of normal gene expression. The databases are interoperable with the Open Systems Pharmacology Suite (PK‐Sim and MoBi) and enable seamless access to a central source of curated cross‐species gene expression data. This will increase data transparency, increase reliability and reproducibility of PBPK model simulations, and accelerate mechanistic PBPK model development in the future.
Establishing the suitability of model‐integrated evidence to demonstrate bioequivalence for long‐acting injectable and implantable drug products: Summary of workshop
Authors: Gong Yuqing , Zhang Peijue , Yoon Miyoung , Zhu Hao , Kohojkar Ameya , Hooker Andrew C. , Ducharme Murray P. , Gobburu Jogarao , Cellière Géraldine , Gajjar Parmesh , Li Bing V. , Velagapudi Raja , Tsang Yu Chung , Schwendeman Anna , Polli James , Fang Lanyan , Lionberger Robert , Zhao Liang 
Published: January 2023

AbstractOn November 30, 2021, the US Food and Drug administration (FDA) and the Center for Research on Complex Generics (CRCG) hosted a virtual public workshop titled “Establishing the Suitability of Model‐Integrated Evidence (MIE) to Demonstrate Bioequivalence for Long‐Acting Injectable and Implantable (LAI) Drug Products.” This workshop brought relevant parties from the industry, academia, and the FDA in the field of modeling and simulation to explore, identify, and recommend best practices on utilizing MIE for bioequivalence (BE) assessment of LAI products. This report summerized presentations and panel discussions for topics including challenges and opportunities in development and assessment of generic LAI products, current status of utilizing MIE, recent research progress of utilizing MIE in generic LAI products, alternative designs for BE studies of LAI products, and model validation/verification strategies associated with different types of MIE approaches.
Automated construction for human–robot interaction in wooden buildings: Integrated robotic construction and digital design of iSMART wooden arches
Authors: Leng Yi , Shi Xinyu , Hiroatsu Fukuda , Kalachev Alexander , Wan Da 
Published: January 2023

AbstractRobotic construction is a powerful means of addressing labor shortages, low productivity, and low sustainability in the construction industry. Even though construction robots have attracted attention in research and practice, in a market condition where the technology and industry scale of the construction industry is yet unable to meet the scale of full automation, human–robot interaction (HRI) is a more adaptable working model. It is crucial to change the level of automation to the level of cooperation. This paper proposes an HRI construction method that aims to provide a new idea for existing robotic construction research, which combines the advantages of manual construction and automated robotic construction. This construction method allows an inexperienced layman to quickly complete the construction of complex timber structures with the assistance of a robot. Furthermore, this automated construction method's advantages, limitations, and potential pitfalls and the environmental, economic, and social sustainability aspects of design, production, and construction are also considered, providing a technical reference for the sustainable development of China's construction industry.
Relocalization based on millimeter wave radar point cloud for visually degraded environments
Authors: Cheng Yuwei , Pang Changsong , Jiang Mengxin , Liu Yimin 
Published: January 2023

AbstractSimultaneously localization and mapping (SLAM) has been widely used in autonomous mobile systems to fulfill autonomous navigation. Relocalization plays an important role in SLAM for closing the loop and eliminating the drift of pose estimation. Traditional methods mostly rely on LiDAR or camera sensors, which may degrade or even fail in rainy or dusty situations or with large illumination changes. In this article, we explore the use of low‐cost commercial millimeter wave (mmWave) radars and propose a noval mmWave radar point cloud‐based relocalization method. Our method first pre‐processes the radar point cloud and, based on that, achieves fast 3‐DOF pose estimation for the robot. We build a prototype and thoroughly evaluate our method using data sets collected by our platform in four complex environments, including street, park, road, and water surface scenarios. The experimental results show that our method consistently outperforms other baseline methods including the vision‐based counterparts, especially in the visual degraded scenes.
Psychometric evaluation of an adapted version of the perceived stress scale for ecological momentary assessment research
Authors: Murray Aja Louise , Xiao Zhouni , Zhu Xinxin , Speyer Lydia Gabriela , Yang Yi , Brown Ruth Harriet , Katus Laura , Eisner Manuel , Ribeaud Denis 
Published: January 2023

AbstractEcological momentary assessment (EMA) methodologies are commonly used to illuminate the predictors and impacts of experiencing subjective stress in the course of daily life. The validity of inferences from this research is contingent on the availability of measures of perceived momentary stress that can provide valid and reliable momentary stress scores. However, studies of the development and validation of such measures have been lacking. In this study, we use an EMA data collection design to examine the within‐ and between‐ person reliability and criterion validity and between‐person gender measurement invariance of a brief EMA‐adapted measure of a widely used trait measure of stress: the Perceived Stress Scale (PSS). Scores showed high internal consistency reliability and significant correlations with a range of criterion validity measures at both the within‐ and between‐person level. Gender measurement invariance up to the scalar level also held for scores. Findings support the use of the EMA‐adapted PSS presented in the current study for use in community‐ascertained samples to address research questions relating to the influences on and effects of momentary stress and their gender differences.
A Dual‐Responsive Artificial Skin for Tactile and Touchless Interfaces
Authors: Wang Hai Lu , Chen Tianyu , Zhang Bojian , Wang Guohui , Yang Xudong , Wu Kunlin , Wang Yifan 
Published: January 2023

AbstractThe progress from intelligent interactions and supplemented/augmented reality requires artificial skins to shift from the single‐functional tactile paradigm. Dual‐responsive sensors that can both detect pre‐contact proximal events and tactile pressure levels enrich the perception dimensions and deliver additional cognitive information. Previous dual‐responsive sensors show very limited utilizations only in proximity perception or approaching switches. Whereas, the approaching inputs from the environment should be able to convey more valuable messages. Herein, a flexible iontronic dual‐responsive artificial skin is present. The artificial skin is sensitive to external object's applied pressure as well as its approaching, and can elicit information of target material categories encoded in the proximal inputs. Versatile applications are then demonstrated. Dual‐mode human–machine interfaces are developed based on the devices, including a manipulation of virtual game characters, navigation and zooming in of electronic maps, and scrolling through electronic documents. More importantly, the proof‐of‐concept application of an entirely touchless material classification system is demonstrated. Three types of materials (metals, polymers, and human skins) are classified and predicted accurately. These features of the artificial skin make it highly promising for next‐generation smart engineered electronics.
Dual Structural Design of Platinum‐Nickel Hydrogels for Wearable Glucose Biosensing with Ultrahigh Stability
Authors: Li Guanglei , Wang Chenxin , Chen Yao , Liu Fei , Fan Haoxin , Yao Bin , Hao Jia , Yu Yiting , Wen Dan 
Published: January 2023

AbstractWearable glucose sensors are of great significance and highly required in mobile health monitoring and management but suffering from limited long‐term stability and wearable adaptability. Here a simultaneous component and structure engineering strategy is presented, which involves Pt with abundant Ni to achieve three‐dimensional, dual‐structural Pt‐Ni hydrogels with interconnected networks of PtNi nanowires and Ni(OH)2 nanosheets, showing prominent electrocatalytic activity and stability in glucose oxidation under neutral condition. Specifically, the PtNi(1:3) dual hydrogels shows 2.0 and 270.6 times’ activity in the glucose electro‐oxidation as much as the pure Pt and Ni hydrogels. Thanks to the high activity, structural stability, good flexibility, and self‐healing property, the PtNi(1:3) dual gel‐based non‐enzymatic glucose sensing chip is endowed with high performance. It features a high sensitivity, an excellent selectivity and flexibility, and particularly an outstanding long‐term stability over 2 months. Together with a pH sensor and a wireless circuit, an accurate, real‐time, and remote monitoring of sweat glucose is achieved. This facile design of novel dual‐structural metallic hydrogels sheds light to rationally develop new functional materials for high‐performance wearable biosensors.
Properties and Food Packaging Applications of Solvent Casting‐Made Starch‐Based Films Incorporated with Essential Oils: A Review
Authors: Othman Siti Hajar , Kahar Nurul Syafiqah , Nordin Norhazirah , Ahmad Shapi'i Ruzanna 
Published: January 2023

AbstractBiopolymer films particularly starch films are promising alternatives to non‐biodegradable petroleum‐based materials because they are cheap, available in abundance, and biodegradable. Nonetheless, the weak mechanical and barrier properties of the films restrict their usage. Other additives such as essential oils (EOs) incorporate into the films may enhance the restricted properties and add functionality to films. However, knowledge of the effects of EOs addition in starch films across food packaging applications is not fully elucidated. This paper provides an overview of the various types of EOs used in the production of starch films produced via the solvent casting method, the effects of EOs on the properties of starch films, and the application of the films for food packaging, particularly for fruits and meats. The films bring a high potential to extend the shelf life of food due to the antioxidant and antimicrobial properties of the EOs.
Trends and Hotspots of Starch Fermentation Research: Bibliometric Analysis Based on CiteSpace
Authors: Zheng Ziwei , Li Haiteng , Wang Xin , Yang Shengyu , Li Xingke 
Published: January 2023

AbstractFermentation is a common topic in starch scientific research and is widely utilized in the food and pharmaceutical industry. Although many papers on starch fermentation have been published in the past 10 years (2012–2022), reviews of the overall knowledge structure of the discipline are relatively rare. Research in this area progresses rapidly. To stay current with the emerging trends, this review uses a bibliometric analysis method based on CiteSpace software to analyze, review, and briefly comment on selected articles published in the field of starch fermentation over the past 10 years. The research progress and emerging trend of starch fermentation are discussed. A total of 4943 references are used for analysis on CiteSpace. The results showed that from 2012 to 2022, the rate of published articles and the number of citations have increased. China is in first place by number of publications. Jiangnan University is the most prolific institutions, and the most prolific author is Akihiko Kondo. Among the category collaboration, “Agriculture” and “Food Science and Technology” are the first in the two sets of 5 year periods. The keyword “ethanol” shows the highest burst strength level. In addition, food fermentation and clean energy research are the main areas of concern in this field. This review aims to provide new insights for promoting the industrialization development and clinical application of starch fermentation technology.
Formation of Multiple Supramolecular Helices for Spontaneous Resolution
Authors: Weng Peimin , Yan Xiaosheng , Jiang Yun‐Bao 
Published: January 2023

AbstractRelating supramolecular helices to the spontaneous resolution that generates conglomerate crystals is meaningful to the production of enantiopure compounds and to the understanding of natural homochirality as well. While homochiral elongation is favored along the axis of 1D supramolecular helical chains, conglomerate crystallization requires a 3D homochiral framework. This inspires us to explore new avenues to the spontaneous resolution through the formation of multiple supramolecular helices during crystallization. This Concept outlines and reviews multiple supramolecular helices found in the conglomerate crystals, i. e. three supramolecular helices along one crystallographic axis and two or three supramolecular helices along different crystallographic axes, followed by our observations of homochiral elongation of the helicity of the helical building blocks, the azapeptides, during the formation of supramolecular helices, as well as the spontaneous resolution of amino acid alanine that is made into a helical azapeptide derivative via the formation of supramolecular helices along two different crystallographic axes.