bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERBEDAAN KADAR SGOT, SGPT, DAN ALBUMIN SEBELUM DAN SESUDAH 3 SERI KEMOTERAPI PACLITAXEL-CARBOPLATIN PADA KASUS KANKER SERVIKS STADIUM IIIB DI RSUP SANGLAH DENPASAR PERIODE 1 JANUARI–31 JUNI TAHUN 2018
Authors: .H Stefanus K , W.S I Gd Ngurah Harry , Aryana Made Bagus Dwi , Budiana I Nyoman Gd 
Published: August 2023

ABSTRAK

Latar Belakang : Kanker serviks merupakan keganasan yang terjadi pada leher rahim dan di yakini sebagai salah satu penyebab kematian terbanyak pada wanita di seluruh dunia. Kemoterapi merupakan alternatif yang paling efektif dalam pengobatan kanker serviks. Jenis kemoterapi yang sering diberikan adalah kombinasi paclitaxel-carboplatin namu kombinasi obat ini memiliki efek hepatoxic yang dapat mengakibatkan perubahan kadar enzim di hati seperti SGOT, SGPT, dan albumin.
Tujuan : Mengetahui perbedaan kadar SGOT, SGPT, dan albumin pada pasien kanker serviks stadium IIIB di RSUP Sanglah Denpasar periode 1 Januari–31 Juni tahun 2018
Metode : Penelitian observasional dengan desain penelitian longitudinal. Teknik pengumpulan sampel berupa total sampling dimana data penelitian berasar dari data sekunder rekam medis pasien kanker serviks yang menjalani 3 seri kemoterapi paclitaxel-carboplatin di RSUP Sanglah Denpasar periode 1 Januari–31 Juni tahun 2018 yang telah memenuhi kriteria inklusi dan eksklusi
Hasil : Terdapat peningkatan kadar SGOT, SGPT, dan albumin pada pasien kanker serviks stadium IIIB setelah 3 seri kemoterapi. Namun peningkatan yang bermakna hanya terjadi pada kadar SGPT dimana hanya peningkatan rerata SGPT yang memiliki nilai p<0,05. SGOT mengalami peningkatan kadar sebanyak 3,33 u/L (16,3%) lalu SGPT 6,55 u/L (44,7%) dan albumin 0,12 g/dL (3,2%).

Kata Kunci : Kanker serviks, SGOT, SGPT, albumin.
Metastatic cervical carcinoma to the brain masquerading as a butterfly glioma: A case report
Authors: Kimata Anna , Abdulrazeq Hael , Kritselis Michael , Riccelli Tori , Anderson Matthew , Dowd Richard , Dellale Ivana , Sampath Prakash 
Published: August 2023

Background:
Metastatic cervical cancer to the brain is a rare occurrence, representing approximately 1.5% of metastatic cases. We report a rare presentation of cervical cancer with brain metastasis to the corpus callosum. The patient was initially suspected to have a primary glioma but was diagnosed with a metastatic cervical carcinoma lesion through both stereotactic and then opens biopsy.

Case Description:
A 53-year-old female, with Stage III adenosquamous cervical carcinoma, presented with a large heterogeneously enhancing mass in the corpus callosum body with extension in the cingulate gyrus concerning for glioma. A stereotactic biopsy revealed hypercellular and gliotic brain tissue, while an open biopsy showed an epithelioid neoplasm consistent with metastatic cervical adenosquamous carcinoma. The patient underwent a craniotomy and recovered well and was discharged in stable condition.

Conclusion:
Brain metastases from cervical cancer are uncommon. We present a rare case of metastatic cervical carcinoma which appeared on imaging to mimic a butterfly glioma. The patient’s history and histopathological examination were essential in determining the correct diagnosis and receiving timely treatment.
Malignant bihemispheric cerebral edema after cranioplasty – An extension of the Monro-Kellie doctrine and predictive factors
Authors: Bhatjiwale Mrudul Mohinish , Mariswamappa Kiran , Chandrachari Komal Prasad , Bhatjiwale Mohinish , Joshi Tanvi , Hegde Thimappa , Kulkarni Akshay Vijay 
Published: August 2023

Background:
Several changes in normal pressure dynamics on the brain occur with a decompressive craniectomy and subsequent cranioplasty. Dead space volume is an important factor contributing to intracranial volume postcranioplasty. A decrease in this volume due to negative suction drain along with relative negative pressure on the brain with the loss of external atmospheric pressure may lead to fatal cerebral edema.

Case Description:
A 52-year-old gentleman with a 210 mL volume and middle cerebral artery territory infarction underwent an emergency craniectomy and 6 months later a titanium mold cranioplasty. Precranioplasty computed tomography (CT) scan evaluation revealed a sunken skin flap with a 9 mm contralateral midline shift. Immediately following an uneventful surgery, the patient had sudden fall in blood pressure to 60/40 mmHg and over a few min had dilated fixed pupils. CT revealed severe diffuse cerebral edema in bilateral hemispheres with microhemorrhages and expansion of the sunken right gliotic brain along with ipsilateral ventricular dilatation. Despite undergoing a contralateral decompressive craniectomy due to the midline shift toward the right, the outcome was fatal.

Conclusion:
Careful preoperative risk assessment in cranioplasty and close monitoring postprocedure is crucial, especially in malnourished, poststroke cases, with a sinking skin flap syndrome, and a long interval between decompressive craniectomy and cranioplasty. Elective preventive measures and a low threshold for CT scanning and removal of the bone flap or titanium mold are recommended.
Inhaled corticosteroids’ effect on COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials
Authors: Badi Yasra , Hammad Mohamed , Tawfik Abdelrahman G. , Eshag Mona Muhe Eldeen , Elhady Mahmoud M. , Ragab Khaled Mohamed , Nourelden Anas Zakarya , Gamal Mohamed Hesham , Fathallah Ahmed Hashem 
Published: August 2023

Background More than six million people died due to COVID-19, and 10-15% of infected individuals suffer from post-covid syndrome. Corticosteroids are widely used in the management of severe COVID-19 and post-acute COVID-19 symptoms. This study synthesizes current evidence of the effectiveness of inhaled corticosteroids (ICS) on mortality, hospital length-of-stay (LOS), and improvement of smell scores in patients with COVID-19. Methods We searched Embase, Web of Science, PubMed, Cochrane Library, and Scopus until Aug 2022. The Cochrane risk of bias tool was used to assess the quality of studies. We evaluated the effectiveness of ICS in COVID-19 patients through measures of mortality, LOS, alleviation of post-acute COVID-19 symptoms, time to sustained self-reported cure, and sense of smell (visual analog scale (VAS)). Results Ten studies were included in the meta-analysis. Our study showed a significant decrease in the LOS in ICS patients over placebo (MD = -1.52, 95% CI [-2.77 to -0.28], p-value = 0.02). Patients treated with intranasal corticosteroids (INC) showed a significant improvement in VAS smell scores from week three to week four (MD =1.52, 95% CI [0.27 to 2.78], p-value = 0.02), and alleviation of COVID-related symptoms after 14 days (RR = 1.17, 95% CI [1.09 to 1.26], p-value < 0.0001). No significant differences were detected in mortality (RR= 0.69, 95% CI [0.36 to 1.35], p-value = 0.28) and time to sustained self-reported cure (MD = -1.28, 95% CI [-6.77 to 4.20], p-value = 0.65). Conclusion We concluded that the use of ICS decreased patient LOS and improved COVID-19-related symptoms. INC may have a role in improving the smell score. Therefore, using INC and ICS for two weeks or more may prove beneficial. Current data do not demonstrate an effect on mortality or time to sustained self-reported cure. However, the evidence is inconclusive, and more studies are needed for more precise data.
Application of the Perme Score to assess mobility in patients with COVID-19 in inpatient units
Authors: Nascimento Milena Siciliano , Talerman Claudia , Eid Raquel A. C. , Brandi Simone , Gentil Luana L.S. , Semeraro Fernanda M. , Targa Fabiano B. 
Published: August 2023

Objective To evaluate the ability of the Perme Score to detect changes in the level of mobility of patients with COVID-19 outside the intensive care unit. Method A retrospective cohort study was conducted in inpatient units of a private hospital. Patients older than 18, diagnosed with COVID-19, who were discharged from the intensive care unit and remained in the inpatient units were included. The variables collected included demographic characterization data, length of hospital stay, respiratory support, Perme Score values at admission to the inpatient unit and at hospital discharge and the mobilization phases performed during physical therapy. Result A total of 69 patients were included, 80% male and with a mean age of 61.9 years (SD=12.5 years). The comparison of the Perme Score between the times of admission to the inpatient unit and at hospital discharge shows significant variation, with a mean increase of 7.3 points (95%CI:5.7-8.8; p<0.001), with estimated mean values of Perme Score at admission of 17.5 (15.8; 19.3) and hospital discharge of 24.8 (23.3; 26.3). There was no association between Perme Score values and length of hospital stay (measure of effect and 95%CI 0.929 (0.861; 1.002; p=0.058)). Conclusion The Perme Score proved effective for assessing mobility in patients diagnosed with COVID-19 with prolonged hospitalization outside the intensive care setting. In addition, we demonstrated by the value of the Perme Score that the level of mobility increases significantly from the time of admission to inpatient units until hospital discharge. There was no association between the Perme Score value and length of hospital stay.
Development of Competency-Based Instruction in the Challenging Era: A Case Study of French for Airline Ground Services
Authors: CHITKLA Kantaphong 
Published: August 2023

In this decade, the world faces to several challenges such as economic volatility and transformation of work styles and lifestyle changed at the moment. It is undeniable that the travel by plane is in high demand before and after Covid-19. The airport ground services need competent personnel. The teaching of French at the university does not neglect these situations. French Program of Khon Kaen University created the French for Airline Ground Service course in 2011. Nowadays, this course opens its doors to accommodate 80 percent of the 3rd year of French major. It is interesting to study the development of the course and analyze the teaching and learning methods. This research was based on the action-oriented approach to pedagogy and teaching on the basis of competence. The results show that this course offers learners French at the B1+ level of CEFR and the basic skills for the airport ground staff in relation to the Rome N2201 of the Pôle Emploi of French Republic. In terms of learning activities, learners follow the Interaction Mode of Instruction to acquire life and career skills. Moreover, the software applications on flight preparation: Flightradar24 and Windy are used in the learning activities. This brings the learners to practice digital language and technology. Nevertheless, this research lacks the satisfaction of the airline entrepreneurs
Application of K-Mean in Clustering Mapping of Underprivileged Communities
Authors: Prabowo Iwan Ady , Siswanti Sri , Wulandari Lilis 
Published: August 2023

Jatiyoso is one of 17 sub-districts in Karanganyar Regency, Central Java Province. Through this sub-district office, residents can take care of various forms of permits. There are many other functions and duties of the subdistrict office. The distance from the county seat is 30.0 km to the south. Jatiyoso is divided into 9 village areas, namely, Jatisawit, Jatiyoso, Karangsari, Petung, Tlobo, Wonokeling, Wonorejo, and Wukirsawit. With the total population of Jatiyoso District is 40,709 people. With a large population, and also a large amount of poverty. To help reduce poverty in Jatiyoso District, Jatiyoso District, an information system is needed that can explain the mapping of poverty areas in Jatiyoso Village. This information system is expected to assist the government in distributing aid to the poor. K-Means method was applied in this study to overcome the problem of grouping poor families by category. According to the findings of study, there were 23 groups of persons with low assets (C1) and four groups of people with substantial assets (C2). The findings of the feasibility testing process with the User Acceptance Test (UAT) respondents agreed (average 95%) that the application of mapping the clustering of poor people using the k-means method can help officers in mapping the poor and facilitate the distribution of aid to the poor in Jatiyoso village
Pterional Approach: Technical Variations, Functional, and Cosmetic Outcome in a Series of 1000 Patients
Authors: Luzzi Sabino , Giotta Lucifero Alice , Baldoncini Matías , Campero Alvaro , Elbabaa Samer K. , Galzio Renato 
Published: August 2023

INTRODUCTION
Most of the versatility of the pterional approach depends on a series of variations progressively reported by several groups, but little emphasized over the years.
The present study condenses the technical notes which the authors adopted in their practice to maximize the surgical freedom of the pterional approach, at once lessening the approach-related complication rate.
METHODS
Data of a series of patients who underwent a pterional approach between January 2011 and May 2021 were retrospectively reviewed focusing on the technical variations compared to the original Yaşargil’s description. The anatomical rationale, technique, and advantages were outlined and validated through the appraisal of functional and cosmetic complications.
RESULTS
994 patients were reviewed. Head extension was avoided in the case of anterior clinoidectomy. A single double-layered galea-pericranium flap was used for duraplasty. The submuscular technique, with compulsive preservation of deep temporal fascia and deep temporal arteries, was preferred for temporalis muscle dissection. McCarty keyhole was never used, thus avoiding exposing the orbit if unnecessary. Widening of the superior orbital fissure and thinning of the orbital roof allowed to significantly increase the working area. The average follow-up was 7.2 years. The overall rate of functional and cosmetic complications was 2.1.
DISCUSSION
In the authors' experience, the gradual adoption of technical variations related to the patient's positioning, soft tissue dissection, bony work, dura opening, and reconstruction allowed to enhance the versatility of the pterional approach concurrently decreasing the risk of functional and cosmetic complications.
Analysis of phytochemical constituent and biological significance of rhododendrons collected from capital of Laliguras, Laliguras municipality, Tehrathum district, Nepal
Authors: Subba Bimala , Baral Chahana Dhakal , Seling Tank Raj , Sharma Khagraj 
Published: August 2023

The largest genus of the Ericaceae family, Rhododendron includes an inspiring number of species. Some of which have been used in the treatment of various ailments such as diseases associated with heart, dysentery, diarrhea, detoxification, fever, constipation, bronchitis and asthma around the world including Nepal. However, systematic study on phytochemistry and pharmacology of Rhododendrons grown in the Capital of Laliguras, Laliguras Municipality, Tehrathum of Nepal is lacking. So this study was conducted to evaluate the antioxidant activity, α-amylase inhibition activity, total phenolic and flavonoid contents of Rhododendron arboretum and Rhododendron campanulatum from Laliguras Municipality, Tehrathum of Nepal. Plant extracts were prepared in methanol by cold percolation method. Phytochemical constituents were analyzed by following standard methods. Antioxidant activity was measured through 2, 2-Diphenyl-1-Picrylhydrazyl assay. Total phenolic and flavonoid content were estimated using Folin–Ciocalteau and aluminum chloride method respectively. Alpha amylase inhibition assay was carried out by starch iodine method. Phytochemical screening of methanolic extract of flower and leaf of R. arboretum and leaves of R. campanulatum displayed the presence of different chemical constituents such as flavonoids, polyphenols, terpenoids, saponins and quinins. Samples showed dose-dependent radical scavenging and α-amylase inhibition activity. Radical scavenging activity and α-amylase inhibition activity of the methanolic extracts of different parts of R. arboretum and R. campanulatum ranged from 19.46 to 95.88% and 13.23 to 68.44% respectively. Flower extracts of R. arboreum showing the strongest radical scavenging activity and α-amylase inhibition with IC50 values 33.61 and 443.44 μg/mL respectively. Among the tested samples, flower extract of R. arboretum showed the strongest antioxidant activity, alpha amylase inhibition activity and contained the highest amount of total phenolic and flavonoid content.
Is restrained eating behaviour associated with pre-pregnancy weight and weight-gain in gestational diabetes?
Authors: KÜÇÜKKASAP CÖMERT Tuğba , YILDIZ Elif , AKPINAR Funda , İSKENDER Cantekin 
Published: August 2023

Aims: The aim of this study was to investigate the association between eating behaviors and pre-pregnancy body mass index (BMI) and body weight gain in individuals with gestational diabetes mellitus.
Methods: This cross-sectional study was conducted in 34 pregnant women diagnosed with gestational diabetes mellitus and 50 nondiabetic women above the 28th week of pregnancy. The Dutch Eating Behavior Questionnaire was used to assess eating habits. A quantitative food frequency questionnaire was used to assess food consumption.
Results: Individuals with gestational diabetes had significantly higher levels of restrained eating behavior scores (27.11±5.98 vs 20.32±6.84) compared to nondiabetic women (p
Combined use of CYFRA 21-1 and CA 125 predicts survival of patients with metastatic NSCLC and stable disease in IMpower150
Authors: Mang Anika , Zou Wei , Rolny Vinzent , Reck Martin , Cigoianu Daniel , Schulze Katja , Holdenrieder Stefan , Socinski Mark A. , Shames David S. , Wehnl Birgit , Patil Namrata S. 
Published: August 2023

BACKGROUND: Patients with non-small cell lung cancer (NSCLC) and stable disease (SD) have an unmet clinical need to help guide early treatment adjustments. OBJECTIVE: To evaluate the potential of tumor biomarkers to inform on survival outcomes in NSCLC SD patients. METHODS: This post hoc analysis included 480 patients from the IMpower150 study with metastatic NSCLC, treated with chemotherapy, atezolizumab and bevacizumab combinations, who had SD at first CT scan (post-treatment initiation). Patients were stratified into high- and low-risk groups (overall survival [OS] and progression-free survival [PFS] outcomes) based on serum tumor biomarker levels. RESULTS: The CYFRA 21-1 and CA 125 biomarker combination predicted OS and PFS in patients with SD. Risk of death was ~4-fold higher for the biomarker-stratified high-risk versus low-risk SD patients (hazard ratio [HR] 3.80; 95% confidence interval [CI] 3.02–4.78; p < 0.0001). OS in patients with the low- and high-risk SD was comparable to that in patients with the CT-defined partial response (PR; HR 1.10; 95% CI 0.898–1.34) and progressive disease (PD) (HR 1.05; 95% CI 0.621–1.77), respectively. The findings were similar with PFS, and consistent across treatment arms. CONCLUSIONS: Biomarker testing shows potential for providing prognostic information to help direct treatment in NSCLC patients with SD. Prospective clinical studies are warranted. ClinicalTrials.gov: NCT02366143
Sources and Prevalence of Aflatoxin B1 in Different Rice Paddies of Punjab and Sindh, Pakistan
Authors: Adrees Usman , Afzal Imran , Chaudhary Ahmed Shabbir , Zia Ramna , Ali Kashif , Chaudary Hassan shabbir 
Published: August 2023

Rice is a major cash crop used all over world. The hygroscopic nature of rice kernel with warm and fumic conditions is favorable to enhance the growth and development of toxigenic fungi which produce mycotoxins. This study estimates the prevalence of aflatoxin B1 in different rice paddies collected from twelve regions of the Punjab and Sindh provinces of Pakistan. All the samples were analyzed for their phenotypic characteristics (appearance, odor, and grain length). Competitive Enzyme Linked Immuno Sorbent Assay (ELISA) was used to evaluate AFB1, both before and after applying the steam decontamination procedure to detoxify aflatoxin contamination. Cultural assay was used to find the source of aflatoxin. PDA and SDA agar were used to detect aflatoxin producing fungal species. Lactophenol Cotton Blue (LCB) staining was used for microscopic identification of fungal contaminants. Paddies from most regions appeared yellowish in color and odorless with the exception of Hafizabad, Jhang, Sheikhupura, and Gujarat (in Punjab), where they appeared blackish yellow in color and with a pungent smell. According to the results, 43 (61.42%) samples were detected with aflatoxin B1 out of 70 samples, with an average of 15.86±1.7 ug/kg, before treating with seam. After treatment with steam, 7 (10%) samples were detected with aflatoxin B1, with an average of 2.55±1.51 ug/kg. Most regions showed the presence of P. chrysogenum with the exception of R.Y. Khan, which showed the presence of A. niger. Steam, on average, reduced aflatoxin to 51.42%. The current study indicates that steam is an effective treatment to eradicate aflatoxin at industrial level. New approaches may be explored to target the contaminants in order to ensure food safety.
Pemahaman Aksara Jepang Dasar melalui Shoudo
Authors: Hoftman Rainhard Oliver , Xaviera Beby Fitri , Zulaeha Elli Rahmawati , Najmudin Onin 
Published: August 2023

Kegiatan pengabdian masyarakat di sekolah ini bermula dari banyaknya acara-acara kejepangan di sekolah-sekolah. Acara tersebut mengangkat budaya Jepang seperti anime, cosplay, film Jepang, dan masakan Jepang. Dari kondisi tersebut terlihat bahwa keingintahuan tentang budaya Jepang disekitar kampus sangat besar. Ditambah lagi dengan meningkatnya industri Jepang di sekitar wilayah Bekasi, seiring dengan meningkatnya penjualan makanan bernuansa kejepangan. Untuk mengakomodir kondisi tersebut diadakanlah pengabdian penulisan huruf Jepang melalui shoudo atau kaligrafi Jepang. Dengan kegiatan ini diharapkan para siswa yang mempunyai keingintahuan untuk belajar Jepang, mempunyai pijakan yang kuat dengan menguasai huruf-huruf Jepang. Dalam mempelajari bahasa Jepang, huruf mempunyai peranan penting. Huruf-huruf bahasa Jepang adalah hiragana, katakana dan kanji. Kesemua huruf tersebut wajib dikuasai dalam mempelajari bahasa Jepang. Dalam shodou huruf-huruf tersebut dipakai untuk mengekspresikan keindahan aksara Jepang. Kata-kata seperti gunung・ yama山, air・ mizu　水, dan tanah ・tsuchi 土merupakan bentuk-bentuk kanji sederhana yang dipergunakan dalam PkM ini. Siswa-siswi yang mengikuti PkM ini berjumlah 30 orang dibagi menjadi 6 kelompok. Hasil dari penulisan aksara Jepang, dipresentasikan di depan kelas, memaparkan kesulitan dalam penulisan melalui shoudou. Antusias mereka terlihat ketika pembelajaran berlangsung huruf-huruf yang mereka tulis, ditulis berulang-ulang sampai mereka benar-benar mengetahui dengan baik.
COVID-19 Experiences of International Students in Vancouver, British Columbia, Canada
Authors: Garg Ajay , Rosada Raymundo , Ariken Jay 
Published: August 2023

This study looked into the lived experiences of international students during the COVID-19 pandemic in Vancouver, British Columbia, Canada. The research focused on how international students viewed the COVID-19 pandemic, their personal, social, economic, health and hygiene, and schooling experiences. A validated and reliable researchers-made questionnaire was used. Weighted means and Fisher’s Exact Hypothesis Testing on Association were used to analyze the responses of the international students. The researchers used Fisher’s exact test since they wanted to know whether the proportions for one variable were different among values of the other variable. Foreign students had a solid grasp of the potential risks COVID-19 posed and accepted the associated lockdown requirements. The survey results indicated that the students’ nationality played a vital role in their perception of their financial health and well-being. Students were insecure with their accommodation, expenses, and scheduling. Lastly, they also felt alone, and economically challenged.