bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of macrophages in rosacea: implications for targeted therapies
Authors: Liu Yi , Zhou Yin , Chu Chenyu , Jiang Xian 
Published: August 2023

IntroductionRosacea, a widespread chronic skin condition, may be influenced by macrophages, key immune cells in the skin, although their exact role is not yet fully understood. This review delves into the function of macrophages, their potential contribution to rosacea pathogenesis, current treatments, and promising macrophage-targeted therapies. It concludes by identifying knowledge gaps and potential areas for future rosacea research.MethodLeveraging systematic and narrative literature review techniques, we conducted a comprehensive search of databases such as PubMed, Embase, and Web of Science. Utilizing keywords like “rosacea” and “macrophages”, we targeted English articles from the last 5 years (2018-2023). We manually checked reference lists of relevant articles for additional studies. We included only articles emphasizing macrophages’ role in rosacea and/or the development of related therapies and published within the specified timeframe.ResultsThe systematic search of electronic databases yielded a total of 4,263 articles. After applying the inclusion and exclusion criteria, 156 articles were selected for inclusion in this review. These articles included original research studies, review articles, and clinical trials that focused on the role of macrophages in rosacea and/or the development of macrophage-targeted therapies for the disease. The selected articles provided a comprehensive and up-to-date overview of the current state of research on macrophages in rosacea, including their function in the skin, the potential mechanisms through which they may contribute to rosacea pathogenesis, and the current treatments and therapies available for the disease. Additionally, the articles identified gaps in knowledge regarding the role of macrophages in rosacea and suggested potential areas for future research.ConclusionThis literature review emphasizes the important role that macrophages, vital immune cells in the skin, may play in the pathogenesis of rosacea, a common chronic inflammatory skin disorder. The selected studies suggest potential mechanisms by which these cells might contribute to rosacea progression, although these mechanisms are not yet fully understood. The studies also spotlight current rosacea treatments and illuminate the promising potential of new macrophage-focused therapies. Despite these insights, significant gaps persist in our understanding of the precise role of macrophages in rosacea. Future research in this area could provide further insights into the pathogenesis of rosacea and contribute to the development of more effective, targeted therapeutic strategies.
Myogenic and cortical evoked potentials vary as a function of stimulus pulse geometry delivered in the subthalamic nucleus of Parkinson’s disease patients
Authors: Campbell Brett A. , Favi Bocca Leonardo , Tiefenbach Jakov , Hogue Olivia , Nagel Sean J. , Rammo Richard , Escobar Sanabria David , Machado Andre G. , Baker Kenneth B. 
Published: August 2023

IntroductionThe therapeutic efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease (PD) may be limited for some patients by the presence of stimulation-related side effects. Such effects are most often attributed to electrical current spread beyond the target region. Prior computational modeling studies have suggested that changing the degree of asymmetry of the individual phases of the biphasic, stimulus pulse may allow for more selective activation of neural elements in the target region. To the extent that different neural elements contribute to the therapeutic vs. side-effect inducing effects of DBS, such improved selectivity may provide a new parameter for optimizing DBS to increase the therapeutic window.MethodsWe investigated the effect of six different pulse geometries on cortical and myogenic evoked potentials in eight patients with PD whose leads were temporarily externalized following STN DBS implant surgery. DBS-cortical evoked potentials were quantified using peak to peak measurements and wavelets and myogenic potentials were quantified using RMS.ResultsWe found that the slope of the recruitment curves differed significantly as a function of pulse geometry for both the cortical- and myogenic responses. Notably, this effect was observed most frequently when stimulation was delivered using a monopolar, as opposed to a bipolar, configuration.DiscussionManipulating pulse geometry results in differential physiological effects at both the cortical and neuromuscular level. Exploiting these differences may help to expand DBS’ therapeutic window and support the potential for incorporating pulse geometry as an additional parameter for optimizing therapeutic benefit.
Intratumoral and peritumoral radiomics model based on abdominal ultrasound for predicting Ki-67 expression in patients with hepatocellular cancer
Authors: Qian Hongwei , Shen Zhihong , Zhou Difan , Huang Yanhua 
Published: August 2023

BackgroundHepatocellular cancer (HCC) is one of the most common tumors worldwide, and Ki-67 is highly important in the assessment of HCC. Our study aimed to evaluate the value of ultrasound radiomics based on intratumoral and peritumoral tissues in predicting Ki-67 expression levels in patients with HCC.MethodsWe conducted a retrospective analysis of ultrasonic and clinical data from 118 patients diagnosed with HCC through histopathological examination of surgical specimens in our hospital between September 2019 and January 2023. Radiomics features were extracted from ultrasound images of both intratumoral and peritumoral regions. To select the optimal features, we utilized the t-test and the least absolute shrinkage and selection operator (LASSO). We compared the area under the curve (AUC) values to determine the most effective modeling method. Subsequently, we developed four models: the intratumoral model, the peritumoral model, combined model #1, and combined model #2.ResultsOf the 118 patients, 64 were confirmed to have high Ki-67 expression while 54 were confirmed to have low Ki-67 expression. The AUC of the intratumoral model was 0.796 (0.649-0.942), and the AUC of the peritumoral model was 0.772 (0.619-0.926). Furthermore, combined model#1 yielded an AUC of 0.870 (0.751-0.989), and the AUC of combined model#2 was 0.762 (0.605-0.918). Among these models, combined model#1 showed the best performance in terms of AUC, accuracy, F1-score, and decision curve analysis (DCA).ConclusionWe presented an ultrasound radiomics model that utilizes both intratumoral and peritumoral tissue information to accurately predict Ki-67 expression in HCC patients. We believe that incorporating both regions in a proper manner can enhance the diagnostic performance of the prediction model. Nevertheless, it is not sufficient to include both regions in the region of interest (ROI) without careful consideration.
Efficacy and safety of Runzao Zhiyang capsule for chronic urticaria: a systematic review and meta-analysis of randomized controlled trials
Authors: Zhang Jian-Feng , Wang Ying-Dong , Lin Peng , Li Jun-Chen , Guo Chen-Qi , Zhai Jing-Bo , Zhang Yu 
Published: August 2023

Background: Chronic urticaria (CU) is a commonly seen skin disorder featured by recurring wheals, with or without angioedema, lasting for at least 6 weeks. Runzao Zhiyang capsule (RZC) has been widely applied to treat patients with CU. This study is aimed at systematically evaluating the efficacy and safety of RZC in treating CU.Materials and Methods: Randomized controlled trials (RCTs) of RZC on treating CU from Chinese and English databases were searched. Data were collected by two independent researchers. The Cochrane Collaboration tool was adopted for evaluating the risk of bias. The meta-analysis was performed with Review Manager 5.3 software. Sensitivity analysis and publication bias assessment were conducted by Stata 14.0 software.Results: Totally 27 studies were included in the analysis, involving 2,703 patients. The pooled results showed that compared with second-generation H1-antihistamines (sgAHs) therapy alone, RZC combined with sgAHs is more effective in improving the total effective rate (RR = 1.32, 95% CI: 1.25 to 1.39, p &lt; 0.00001), the quality of life measured by Dermatology Life Quality Index (DLQI) (MD = −2.63, 95% CI: −3.68 to −1.58, p &lt; 0.00001) and the serum IFN-γ level (SMD = 3.10, 95% CI: 1.58 to 4.62, p &lt; 0.0001), and reducing the recurrence rate (RR = 0.39, 95% CI: 0.27 to 0.55, p &lt; 0.00001), the serum total IgE level (SMD = −2.44, 95% CI: −3.51 to −1.38, p &lt; 0.00001), the serum IL-4 level (SMD = −2.96, 95% CI: −4.10 to −1.83, p &lt; 0.00001), and the incidence of adverse events including dizziness, fatigue, dry mouth, and constipation (RR = 0.53, 95% CI: 0.33 to 0.85, p = 0.009; RR = 0.46, 95% CI: 0.26 to 0.84, p = 0.01; RR = 0.57, 95% CI: 0.34 to 0.95, p = 0.03; RR = 0.24, 95% CI: 0.07 to 0.85, p = 0.03).Conclusion: The current evidence indicates that RZC may be an efficient therapeutic regimen in patients with CU. Nevertheless, owing to the suboptimal quality of the included studies, more large-scale, well-designed RCTs are required to verify the obtained findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; Identifier: CRD42022313177.
Aripiprazole-induced liver injury: a spontaneous reporting database study
Authors: Gao Yunjuan , Wu Chengzhao , Zhai Xingran , Niu Ming , Bai Zhaofang , Song Haibo , Zhao Xu , Wang Jiabo , Xiao Xiaohe 
Published: August 2023

Background: There have been individual case reports of aripiprazole in recent years, both domestically and internationally, but no analysis of the characteristics of the occurrence of adverse reactions/events of drug-induced liver injury with aripiprazole using spontaneous reports has been seen.Methods: Using a retrospective study approach, the 452 adverse reaction/event reports of aripiprazole-induced liver injury collected by the China Adverse Drug Reaction Monitoring System from 1 January 2012 to 31 December 2016 were analyzed and evaluated, and exploring it’s the clinical characteristics and related risk factors for liver injury occurrence.Results: Among 452 cases of aripiprazole-induced liver injury ADR/ADE reports, there were 121 cases classified as serious, accounting for 26.8% of the total. There were 250 male and 202 female patients, with a male-to-female ratio of 1.24:1. The age of patients ranged from 11 to 77 years old, with an average age of (34.56 ± 12.81) years old, and a high proportion of young adults in the total population. Some patients had used the drug off-label or at a higher than recommended dosage. The onset of liver injury was generally within 15–90 days after continuous use, while some patients are also accompanied by nausea, vomiting, and weight gain. 70% of the combined drug instructions listed that may cause liver injury.Conclusion: In clinical practice, healthcare professionals should pay closely attention to the adverse reactions and risk factors of liver injury caused by aripiprazole. If there are potential risk factors for liver injury, early and regular monitoring of liver function should be carried out to reduce the occurrence of adverse reactions.
Cantonese media promotes Chinese cultural identification: structural equation modeling based on Malaysian Chinese
Authors: Liu Nian , Chen Tongyu , Peng Yuqing , Xie Ying 
Published: August 2023

IntroductionLanguage media from one’s hometown is an important means of maintaining cultural identification, especially for minorities. Cantonese media plays an active role in shaping the Chinese cultural identification of ethnic Chinese all over the world. To date, few researchers have undertaken quantitative empirical analyses of the mechanism through which Cantonese media influences cultural identification.MethodsUsing data from 642 Malaysian Chinese, this study established a structural equation model with the partial least squares method.ResultsWe found that the emotional affinity of ethnic Chinese to Cantonese media can influence identification with Chinese culture through the perceived value of Cantonese media and cognition of Chinese culture. The perceived value of Cantonese media (IE = 0.208) and cognition of Chinese culture (IE = 0.068) play partial mediation roles. Meanwhile, emotional affinity to Cantonese media influences cognition of Chinese culture (IE = 0.069) through the chain mediation of perceived value of Cantonese media and cognition of Chinese culture. Age has a partial moderating effect in the structural equation model. Compared with minors, adults’ emotional affinity to Cantonese media can eventually influence identification with Chinese culture (TEdiff = 0.126) more strongly through several mediation paths.DiscussionThe study suggests a need to cultivate the emotional affinity of ethnic Chinese to Cantonese media, improve the multidimensional values of Cantonese media, and endow Cantonese media with functions of cultural dialog and knowledge transmission. The international transmission of Cantonese media could play a vital role in building a cultural community for ethnic Chinese globally.
The implications of varicose vein surgery on sleep evaluation scales
Authors: Acir Ibrahim , Okudan Atay Zeynep Vildan , Atay Mehmet , Yayla Vildan 
Published: August 2023

BackgroundVaricose veins commonly occur on the legs and cause discomfort, pain, and aesthetic issues. Varicose vein surgery has an significant impact on sleep disorders such as Restless Leg Syndrome (RLS), daytime sleepiness (DS), and sleep quality (SQ). We intended to determine if preoperative and postoperative sleep quality, excessive daytime sleepiness, and RLS severity impacted in those who had varicose vein surgery.Materials and methodsThe research included 160 patients who presented to the Cardiovascular Surgery outpatient clinic with symptoms of leg pain and cramping and were diagnosed with venous insufficiency. The Restless Legs Syndrome Study Group Rating Scale (RLSS), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) tests were performed on patients. The patients’ scores on the scales were compared preoperatively and postoperatively.ResultsThe mean age of the 160 patients was calculated to be 48.7 ± 10.6 years. There were 109 female (68.1%) and 51 male (31.9%). The mean ferritin level of the patients was calculated as 61.4 mL/ng (4.3–421 mL/ng). After varicose vein surgery 63% reported improved sleep quality. Individuals with increased DS had lower postoperative RLSS scores and higher SQ. There was a decrease in postoperative RLSS scores and an increase in postoperative SQ in patients with normal DS (p &lt; 0.001). Postoperative RLSS and DS scores were lower in patients with good SQ (p &lt; 0.001).ConclusionPatients had a lower RLSS score, a lower DS score, and a higher SQ after varicose vein surgery. Surgical treatment is critical to improving the quality of life and sleep comfort of patients with varicose veins and sleep disorders.
Global, regional, and national burden of digestive diseases: findings from the global burden of disease study 2019
Authors: Wang Fang , Hu Dingtao , Sun Hongyu , Yan Ziye , Wang Yuhua , Wang Linlin , Zhang Tingyu , Meng Nana , Zhai Chunxia , Zong Qiqun , Hu Wanqin , Yu Guanghui , Zou Yanfeng 
Published: August 2023

BackgroundThe global burden of digestive diseases has been rising in the last 30 years. The rates and trends of incidence, deaths, and disability-adjusted life-years (DALYs) for digestive diseases need to be investigated.MethodsWe extracted the data on overall digestive diseases and by cause between 1990–2019 from the Global Burden of Diseases 2019 website, including the absolute number and the corresponding age-standardized rates of incidence (ASIR), deaths (ASDR), and DALYs (ASDALYs).ResultsGlobally, the incident cases, deaths, and DALYs of digestive diseases in 2019 increased by 74.44, 37.85, and 23.46%, respectively, compared with that in 1990, with an increasing ASIR of 0.09%, as well as decreasing ASDR and ASDALYs of 1.38 and 1.32% annually. The sociodemographic index (SDI) of overall digestive diseases showed a slight increase in ASIR from low to middle-low regions. The downtrend in ASDR and ASDALYs was found in all SDI regions. The burden of incidence was higher in females, while the burden of deaths and DALYs was higher in males for the overall digestive diseases and most causes. The estimated annual percentage changes were significantly associated with the baseline ASIR, ASDR, and ASDALYs for the overall digestive diseases, and the negative correlations between ASDR, ASDALYs, and human development index both in 1990 (R = −0.68, R = −0.69) and 2019 (R = −0.71, R = −0.73) were noticed.ConclusionThe findings indicate that digestive diseases remain a significant public health burden, with substantial variation across countries, sexes, and age groups. Therefore, implementing age, gender, and country-specific policies for early screening and targeted interventions could significantly reduce the global burden of digestive diseases.
Computationally assessing diamond as an ultrafast pulse shaper for high-power ultrawideband radar
Authors: Herrmann Christopher S. , Croman Joseph , Baryshev Sergey V. 
Published: August 2023

Diamond holds promise to reshape ultrafast and high-power electronics. One such solid-state device is the diode avalanche shaper (DAS), which functions as an ultrafast closing switch where closing is caused by the formation of the streamer traversing the diode much faster than 107 cm/s. One of the most prominent applications of DAS devices is in ultrawideband (UWB) radio/radar. Here, we simulate a diamond-based DAS and compare the results to a silicon-based DAS. All DASs were simulated in mixed mode as ideal devices using the drift-diffusion model. The simulations show that a diamond DAS promises to outperform an Si DAS when sharpening the kV nanosecond input pulse. The breakdown field and streamer velocity (∼10 times larger in diamond than Si) are likely to be the major reasons enabling kV sub-50 ps switching using a diamond DAS.
Why go public? Public configurations and the supportive and divergent views towards public district heating in the Netherlands
Authors: Herreras Martinez Sara , Harmsen Robert , Menkveld Marijke , Kramer Gert Jan , Faaij André 
Published: August 2023

IntroductionCities are taking up services of social importance under the (re)municipalisation movement. The Dutch government embarked on an ambitious heat transition and proposed in 2022 to make all district heating projects public or semi-public, with a majority public share. This proposal has sparked intense debates among groups in favour of and against a shift to public ownership.MethodsThis study assessed 16 public projects through qualitative research and uncovered the arguments for and against public ownership among key public and private stakeholders.ResultsWhile public ownership is deemed necessary to meet social objectives and address the shortcomings of private models, critical views question the economic performance and inappropriate political choices in some public projects. These critical views propose alternative ways to safeguard public values, such as ensuring affordability and meeting climate goals. Despite disagreements, public and private actors recognise the shared responsibility and the importance of the other's role. They agree that the central government's proposed mandate for public ownership may limit flexibility at the local level and prevent other effective configurations like public-private partnerships with equal public-private shares.DiscussionReflecting on the study findings, it is debatable whether mandating public ownership nationwide, as proposed by the Dutch government, should become the approach to tackle current challenges instead of allowing more flexibility. The upcoming Heat Act may reduce key issues justifying public ownership, such as affordability, cherry-picking and the lack of transparency of private projects. Further research is needed to determine whether public ownership would enhance citizens' support and speed up realisation. Public ownership may still be necessary if social and cost benefits outweigh those from other configurations or long-term concession contracts are too risky. Implementing regulations protecting public values and enabling the coexistence of public, private or public-private configurations tailored to each unique local context could be an alternative, as successful district heating sectors abroad demonstrate.
Images of the City in Recent Experimental Films
Authors: Brinckmann Christine Noll 
Published: August 2023

Cinq films expérimentaux, trois américains et deux allemands ont été présentés en vue de montrer comment la ville peut devenir un sujet cinématographique à différents égards : soit en représentant la réalité, soit en sélectionnant certains aspects de la réalité, soit en transformant la réalité urbaine d’un point de vue structurel, rythmique, lyrique, etc.
Les films visionnés étaient les suivants : Peter Hutton’s New York portrait Chapter 1 (1977-78) ; Ernie Gehr’s Shift (1972-74) ; David Rimmer’s Real Italian pizza (1971) ; Noll Brinckmann’s The West village meat market (1979) et Upholstered furniture in the open air (1984).
Constructing the artificial obvious
Authors: Carver Torrent Ruth Ann 
Published: August 2023

"Constructing the artificial obvious". (Commentaire du chapitre "An Expedition to the Pole" tiré de "Teaching A Stone To Talk" : Expeditions and Encounters de Annie Dillard).
Les pôles terrestres, paradoxalement centraux et excentrés tout à la fois, sont les points sur lesquels se focalise une expédition qui explore la relation entre la perception, le langage et la créativité. Cet article examine la façon dont Dillard utilise l'imagination comme méthode dans son entreprise, ainsi que le penchant de l'écrivain pour l'excursion inventive en terrain inconnu.
Vers une pragmatique de la négation
Authors: Hamm Albert 
Published: August 2023

Towards a pragmatics of negation.
This paper investigates some of the causes of the unsatisfactory treatment of negation in linguistic theory. Various factors are identified and particularly the fact that negatives often signal a relation to an implicit discourse and that negation has thus a pragmatic dimension which is often neglected. A brief reminder of the limits of the major theories as regards the treatment of negation, will enable us to conclude that the theory of annonciative operations offers the most satisfactory frame, and deals best with the psycholinguistic aspect of negation.
Représentations métalinguistiques et explication grammaticale. Etude de quelques emplois du modal shall en indépendantes et principales
Authors: Arigne Viviane 
Published: August 2023

Metalinguistic representations and grammatical theory. A study of shall in independent and main clauses.
In this article, we propose to see how metalinguistic representations can account for various uses of shall in independent and main clauses. Thee study is made within the framework of Culioli's enunciative theory in which one term is referred to, or located by, another. This concept of oriented reference is used to analyse an etymological semantic value in which two subjets are viewed in reference to each other. We then examine how other oriented relations between terms exert constraints on semantic values or help create new ones : the nature of the terms related - subjects as parameters of the system of reference, syntactical subjects or notional domains - must also be taken into account.