bluuebunny/crossref_metadata_2025_split huggingface dataset:
Object relations couple therapy for a married Korean man with sexual dysfunction
Authors: Koh Eun‐kook , Park Yangjin , Park Tai‐Young 
Published: June 2023

AbstractThis study uses James Donovan's object relations couple therapy to examine the triangle of focus (conflict style, couple characteristics, and family of origin) and triangle of conflict (anxiety, defence mechanisms, and hidden emotions) of a married Korean man with sexual dysfunction (reduced sexual desire, premature ejaculation, and erectile dysfunction). This qualitative study uses thematic analysis to identify, describe, and analyse a family therapy case study. The aim of this study is to examine the couple's interaction patterns and experiences of conflicts related to the husband's erectile dysfunction. The researchers induced patterns or topics by repeatedly reading and comparing the data. Then, they textualised and analysed the relevant data. To ensure the reliability and validity of the data analysis, the researchers conducted shared coding sessions to review and discuss the initial codes and the generated main themes and subthemes, triangulating the qualitative data. Findings show that a newlywed husband's sexual dysfunction is associated with his emotional resistance towards his wife's unilateral pursuit over their sexual relationship and the negative emotions triggered by their dysfunctional interactions. Further, couple characteristics, conflict style (dysfunctional interactions), and family‐of‐origin factors (transference and patrilocality) influenced their sexual relationship. Therefore, therapists who counsel Korean couples with sexual issues may pay attention to the sociocultural factors, interactional patterns, and psychological factors associated with unresolved issues with their families of origin.
HPW supported on ammonium hexafluorosilicate modified Hβ: Efficient catalysts for ethylene glycol and methyl tert‐butyl ether reaction with high selectivity and stability
Authors: Jiang Hui , Wang Hefang , Ma Xiaofei , Shao Kai , Wang Cui 
Published: June 2023

A series of HPW supported on ammonium hexafluorosilicate (AHFs) modified Hβ (30HPW/Hβ‐Si(x)) was successfully prepared. After Hβ zeolite was pretreated with 0.1 mol·L−1 AHF's solution, the Brønsted/Lewis ratio of Hβ‐Si(0.1) increased compared with those of Hβ, and the strong acid density of 30HPW/Hβ‐Si(0.1) decreased compared with those of 30HPW/Hβ respectively. Strong acidic sites and Lewis acid sites are catalytic sites for by‐products diisobutene and ethylene glycol oligomers, which deposited on the catalyst result in the deactivation of catalysts. According to the results of characterization, the internal Si‐OH groups of Hβ (strong acidity sites) were filled with silicon of AHFs. The extraframework aluminum (strong acid sites) was removed by the H+, which is the hydrolysis of AHFs. In addition, the hydrophobicity of 30HPW/Hβ‐Si(0.1) was also improved compared with that of 30HPW/Hβ due to the SiO2/Al2O3 ratio of Hβ increased after treatment by 0.1 mol·L−1 AHFs solution. The 30HPW/Hβ‐Si(0.1) maintained an 80% conversion of methyl tert‐butyl ether and 100% selectivity to ethylene glycol mono‐tert‐butyl ether and DBE ethylene glycol bis‐tert‐butyl ether with 336 h of time on stream.
The future of anatomy teaching post‐pandemic: An academic viewpoint
Authors: Bond Alistair P. , Kelsey Alethea , Aitken Gill 
Published: June 2023

AbstractThe COVID‐19 pandemic caused major disruption to anatomical teaching worldwide with both lectures and practicals being moved online. Throughout this period anatomists were able to find new and innovative ways to teach and to aid student learning via a variety of delivery modes. This study aimed to interview anatomists who were involved in teaching undergraduate medical students at UK universities to document the changes that occurred and to understand academic perceptions of pandemic delivery to comprehend how anatomy education may change in the long term. Results suggest that academics are likely to continue to deliver anatomical lectures online post‐pandemic akin to a flipped classroom approach, although caution was noted regarding ‘at‐risk’ student groups. No academics wished to see continued delivery of practical classes online, however, resources designed or invested in during the pandemic will be integrated into practical classes or pre‐class preparation allowing for a more complete student experience. No clear picture emerged as to the preferred way staff and students will communicate in the current post‐pandemic hybrid working environment and beyond. This will likely only be resolved when a new pattern of home working evolves in UK institutions. This report is the first to detail the academic vision of anatomy teaching in a post‐pandemic world and will be useful to those adapting to these changes and for those pedagogical researchers targeting where anatomical education research should focus moving forward.
Narrative review on open access institutional repositories and knowledge sharing in South Africa
Authors: Kodua‐Ntim Kwame 
Published: June 2023

AbstractThis brief communication conveys a critical assessment of the benefits, challenges, and potential of Open Access Institutional Repositories (OAIRs) for knowledge sharing in South Africa. The review identifies best practices and recommendations to promote and improve their usage. Researchers need training and support to understand guidelines and best practices for depositing their work. Limited funding for OAIRs can be addressed by government funding or exploring alternative models. Legal and policy frameworks must support OAIRs and ensure they comply with international standards. Proper management and indexing policies enhance institutional visibility and information retrieval. OAIRs promote collaboration and cooperation among researchers and provide a platform for knowledge sharing and feedback. Standardized platforms and frameworks ensure digital outputs are accessible and usable for the academic community. Sharing knowledge on self‐archiving encourages researchers to deposit their works. Formal reviews must focus on metadata and ensure that articles are from DHET‐accredited journals and that theses and dissertations meet institutional requirements. These efforts promote open access and preserve scholarly works for future generations.
Synthesis of hydroxyethyl starch 200/0.5‐loaded albumin nanoparticles: biocompatibility and interaction mechanism
Authors: Qu Lingyan , Zhou Haixia , Zhang Jianzhong , Huang Shaoyan , Liu Mingming 
Published: June 2023

AbstractWe aimed to synthesize hydroxyethyl starch (HES) 200/0.5‐loaded bovine serum albumin nanoparticles (HBNs) and investigate the compatibility and binding mechanism in simulated physiological environments. Here, to elucidate the morphology, biocompatibility, and formation mechanism of HBNs, techniques such as scanning electron microscopy, haemolysis test, fluorescence, and circular dichroism spectroscopy were applied. The thermodynamic parameters at body temperature (ΔS° = −26.7 J·mol−1·K−1, ΔH° = −3.20 × 104 J·mol−1, and ΔG = −2.35 × 104 J·mol−1) showed a 1:1 binding stoichiometry, which was formed by hydrogen bonds and van der Waals interactions. In addition, the conformational analysis showed that the microenvironment of fluorophores was altered with the adaptational protein secondary structural changes. Energy transfer occurred from the fluorophores to HES with a high possibility. All these results provided accurate and complete primary data for demonstrating the interaction mechanisms of HES with BSA, which helps to understand its pharmaceutical effects in blood.
Ultraviolet photodissociation spectra of singly protonated hexapeptides DYYVVR, DYFVVR, and DFYVVR at room temperature
Authors: Jeon Hyo Nam , Kwon Jang Han , Kang Hyuk 
Published: June 2023

AbstractDYYVVR is a tryptic peptide of Janus kinase 3 and has the two active tyrosine residues needed for the regulation of the protein's activity by phosphorylation. As a proof‐of‐concept experiment for localization of phosphorylation site, two‐dimensional ultraviolet‐mass spectrometry of singly protonated DYYVVR has been investigated at room temperature. Comparing the absorption spectrum with those of peptides with single phenylalanine substitution, DYFVVR and DFYVVR, it is confirmed that the ultraviolet (UV) absorption below 35 100 cm−1 is due to the first tyrosine residue. Combined with the fact that the absorption of a phosphorylated tyrosine is shifted above 37 500 cm−1, two‐dimensional analysis employing mass spectrometry and ultraviolet spectroscopy can be used as a tool for localization of phosphorylation site in a peptide.
Lavandula stoechas L. subsp. stoechas, a New Herbal Source for Ursolic Acid: Quantitative Analysis, Purification and Bioactivity Studies
Authors: Aydin Tuba , Saglamtas Ruya , Gumustas Mehmet , Genisel Mucip , Kazaz Cavit , Cakir Ahmet 
Published: June 2023

AbstractIn this study, methanol, ethanol, methanol‐dichloromethane (1 : 1, v/v), acetone, ethyl acetate, diethyl ether, and chloroform extracts of lavender (Lavandula stoechas L. subsp. stoechas) were prepared by maceration, and the ursolic acid contents in the extracts were determined quantitatively by HPLC analyses. The present results show that the methanol‐dichloromethane (1 : 1, v/v) solvent system is the most efficient solvent system for the extraction of ursolic acid from the plant sample with the highest yield (2.22 g/100 g plant sample). In the present study, a new practical method for the isolation of ursolic acid from polar extracts was also demonstrated for the first time. The inhibition effects of the extracts and ursolic acid were also revealed on α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and human carbonic anhydrase I and II enzymes by determining IC50 values for the first time. The extracts and ursolic acid acted as potent antidiabetic agents by strongly inhibiting the α‐glycosidase activity, whereas they were found to be very weak neuroprotective agents. In view of the present results, L. stoechas and its major metabolite, ursolic acid, can be recommended as a herbal source to control postprandial blood sugar levels and prevent diabetes by delaying the digestion of starch in food.
Recalcitrant course of bullous pemphigoid indicating coexisting hypereosinophilic syndrome: A case report and literature review
Authors: Ganji Raziyeh , Diab Reem , Mousavi Farideh , Abdollahimajd Fahimeh 
Published: June 2023

Key Clinical MessageAs dermatologists, we must be aware that even limited localized lesions may signal a life‐threatening condition, for which early diagnosis and treatment can improve the prognosis.AbstractBullous pemphigoid is an autoimmune disorder characterized by blister formation. Hypereosinophilic syndrome is a myeloproliferative disorder featuring papules, nodules, urticarial lesions, and blisters. The coexistence of these disorders may highlight the involvement of common molecular and cellular factors. Here, we describe a 16‐year‐old patient with hypereosinophilic syndrome and bullous pemphigoid.
Delayed pleuroperitoneal leak in an otherwise uncomplicated course of peritoneal dialysis
Authors: Kwan Victor Shou Yee , Leibowitz Saskia 
Published: June 2023

Key Clinical MessagePleuroperitoneal leaks are rare and normally arise as an early complication in peritoneal dialysis. This case illustrates the importance of considering pleuroperitoneal leaks as a cause for pleural effusions—even if peritoneal dialysis has been longstanding and uncomplicated.AbstractA 66‐year‐old male on peritoneal dialysis for 15 months presented with dyspnoea and low ultrafiltration volumes. Chest radiography revealed a large right‐sided pleural effusion. Pleural fluid sampling and peritoneal scintigraphy confirmed a pleuroperitoneal leak.
A case of pyoderma gangrenosum around the urethral meatus aggravated by COVID‐19 infection and further worsened due to the development of pyogenic osteomyelitis 8 years after urostomy
Authors: Kondo Makoto , Matsushima Yoshiaki , Nakanishi Takehisa , Habe Koji , Yamanaka Keiichi 
Published: June 2023

Key Clinical MessageAfter the infection with COVID‐19, pyoderma gangrenosum worsened and further led to necrosis following pyogenic osteomyelitis. Infection is a major exacerbating factor in pyoderma gangrenosum.
Endovascular management of post PCNL vascular injuries
Authors: Salimi Javad , Rasekhi Siahkalmahalleh Mohammad , Miratashi Yazdi Seyed Amir 
Published: June 2023

Key Clinical MessageAlthough percutaneous nephrolithotomy (PCNL) is a gold standard treatment of large kidney stones, vascular injuries like pseudoaneurysm (PA) and arteriovenous fistula (AVF) may occur due to renal punctures. These endovascular complications need urgent intervention to be diagnosed and managed early. In this case series, 14 patients who had hematuria after PCNL were managed by using angiography to identify the vascular pathology. Among them, we identified 10 patients with PA and 4 patients with AVF, 1 patient with both subscapular hematoma and PA. Angiographic embolization was done successfully in all patients. Based on our results, in cases with peripheral parenchymal damage, PA was common and in cases with hilar damage, AVF was common. No other complication and rebleeding was detected after embolization. Based on our study, angiography can be used as a safe and effective method to detect and treat vascular injuries immediately and successfully.
Azathioprine‐induced lymphoma in a patient with Takayasu arteritis: A case report from Iraq
Authors: Awadh Nabaa Ihsan , Al‐Osami Mohammed Hadi , Hashim Hashim Talib , Al‐Obaidi Ahmed Dheyaa , Al‐Obaidi Mustafa Najah , Abdlkarim Sumaya Abdulhasan 
Published: June 2023

Key Clinical MessageAzathioprine, used for vasculitis and connective tissue diseases, carries long‐term cancer risks. This case report raises awareness among healthcare providers about such risks and emphasizes the need for taking necessary precautions to avoid them while treating such diseases.AbstractWe present an Azathioprine‐induced lymphoma case in a 51‐year‐old male patient with Takayasu arteritis who presented with painless cervical swelling, itching, weight loss, and decreased appetite. This case report aims to increase awareness of the potential long‐term cancer risks associated with azathioprine use in the treatment of chronic diseases.
Metal–Organic Framework Derived Cu−Ag Interface for Selective Carbon Monoxide Electroreduction to Acetate
Authors: Liu Chang , Yan Wei , Wen Yan , Huang Zhongliang , Chen Bo , Li Yunhua , Huang Xiaoqing 
Published: June 2023

AbstractElectrochemical carbon monoxide reduction reaction (CORR) is a potential way to obtain high‐value multi‐carbon (C2+) products. However, achieving high selectivity to acetate is still a challenge. Herein, we develop a two‐dimensional Ag‐modified Cu metal–organic framework (Ag0.10@CuMOF‐74) that demonstrates Faradaic efficiency (FE) for C2+ products up to 90.4 % at 200 mA cm−2 and an acetate FE of 61.1 % with a partial current density of 122.2 mA cm−2. Detailed investigations show that the introduction of Ag on CuMOF‐74 favors the generation of abundant Cu−Ag interface sites. In situ attenuated total reflection surface enhanced infrared absorption spectroscopy confirms that these Cu−Ag interface sites improve the coverage of *CO and *CHO and the coupling between each other and stabilize key intermediates *OCCHO and *OCCH2, thus significantly promoting to the acetate selectivity on Ag0.10@CuMOF‐74. This work provides a high‐efficiency pathway for CORR to C2+ products.
A lattice‐based blind ring signature scheme for sensitive data protection in blockchain applications
Authors: Khanum Saba , Mustafa Khurram 
Published: June 2023

SummaryEvery transaction is made public and verified by a third party, and the transparency of blockchain applications leads to privacy leaks. Everyone can access the transaction, making it easier for network analysis to identify the user's identity, which is a major problem with the blockchain. Financial institutions have become hesitant to adopt blockchain technology; as a result, preventing its spread. To confirm that encryption and security are maintained for transactions in the blockchain, this research introduces a zero‐knowledge proof (ZKP) based transaction validation scheme. To increase the security of blockchain applications, the proposed lattice‐based blind ring signature (LBRS) scheme integrates blind and ring signatures and is applied to sensitive data. The data are encrypted using this encryption scheme before being stored with the transactional information in the blocks. The encrypted data is then stored in the blocks, which users can retrieve after verification. The encrypted data is then stored in blocks, which users can retrieve after verification. A verification scheme based on the ZKP is used to prevent unauthorized access and changes to the data. The proposed LBRS scheme meets the security analysis requirement. The performance of an LBRS scheme is compared to other relevant models in terms of execution time, encryption time, and decryption time. Overall, the results are more encouraging and reassuring than other relevant works of interest. Finally, this model provides better computational security and satisfies the requirements like correctness and security analysis.
Cages versus Sheets: A Critical Comparison in the Size Range Expected for Methylaluminoxane (MAO)
Authors: Collins Scott , Linnolahti Mikko 
Published: June 2023

AbstractNew cage models (MeAlO)n(Me3Al)m (n=16, m=6 or 7) isomeric with previously reported sheet models for the principle activator found in hydrolytic MAO (h‐MAO) are compared at M06‐2X and MN15 levels of theory using density functional theory with respect to their thermodynamic stability. Reactivity of the neutrals or corresponding anions with formula [(MeAlO)16(Me3Al)6Me]− towards chlorination, and loss of Me3Al is explored while reactivity of the neutrals towards formation of contact‐ and outer‐sphere ion pairs from Cp2ZrMe2 and Cp2ZrMeCl is examined. The results suggest on balance that a cage model for this activator is less consistent with experiment than an isomeric sheet model, although the latter are more stable based on free energy.
Metal‐Catalyst‐Free One‐Pot Aqueous Synthesis of trans‐1,2‐Diols from Electron‐Deficient α,β‐Unsaturated Amides via Epoxidation Using Oxone as a Dual Role Reagent
Authors: Zhang Ming‐Zhong , Wang Ping , Liu Hai‐Yan , Wang Dailian , Deng Ya , Bai Yu‐Heng , Luo Fei , Wu Wen‐Yu , Chen Tieqiao 
Published: June 2023

AbstractIn organic synthesis, incorporating two functional groups into the carbon‐carbon double bond of α,β‐unsaturated amides is challenging due to the electron‐deficient nature of the olefin moiety. Although a few examples of dihydroxylation of α,β‐unsaturated amides have been demonstrated, producing cis‐1,2‐diols using either highly toxic OsO4 or other specialized metal reagents in organic solvents, they are limited to several specific amides. We describe herein a general and one‐pot direct synthesis of trans‐1,2‐diols from electron‐deficient α,β‐unsaturated amides through dihydroxylation using oxone as a dual‐role reagent in water. This reaction does not require any metal catalyst and produces non‐hazardous and nontoxic K2SO4 as the sole byproduct. Moreover, epoxidation products could also be selectively formed by adjusting the reaction conditions. By the strategy, the intermediates of Mcl‐1 inhibitor and antiallergic bioactive molecule can be synthesized in one pot. The gram‐scale synthesis of trans‐1,2‐diol which is isolated and purified by recrystallization further shows the potential applications of this new reaction in organic synthesis.
Vitamin D and diabetic peripheral neuropathy: A multi‐centre nerve conduction study among Chinese patients with type 2 diabetes
Authors: Pang Chunyang , Yu Huan , Cai Yunlei , Song Mengwan , Feng Fei , Gao Lingfei , Li Kezheng , Chen Yinuo , Xie Jiali , Cheng Yifan , lin Er , Pan Xinnan , Zhang Wanli , Deng Binbin 
Published: June 2023

AbstractAimsIncreasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi‐centre study sought to investigate these associations based on objective quantifications.Materials and MethodsInformation on DPN‐related symptoms, signs, all diabetic microvascular complications, and nerve conduction abilities (quantified by nerve conduction amplitude and velocity, F‐wave minimum latency (FML) of peripheral nerves) were collected from a derivation cohort of 1192 patients with type 2 diabetes (T2D). Correlation, regression analysis, and restricted cubic splines (RCS) were used to explore linear and non‐linear relationships between vitamin D and DPN, which were validated in an external cohort of 223 patients.ResultsPatients with DPN showed lower levels of vitamin D than those without DPN; patients with vitamin D deficiency (<30 nmol/L) tended to suffer more DPN‐related neurological deficits (paraesthesia, prickling, abnormal temperature, ankle hyporeflexia, and distal pall hypoesthesia correlating with MNSI‐exam score (Y = −0.005306X + 2.105, P = 0.048). Worse nerve conduction abilities (decreased motor nerve amplitude, sensory nerve amplitude, motor nerve velocity, and increased FML) were also observed in these patients. Vitamin D had a significant threshold association with DPN (adjusted OR = 4.136, P = 0.003; RCS P for non‐linearity = 0.003) and correlates with other microvascular complications (diabetic retinopathy and diabetic nephropathy).ConclusionsVitamin D is associated with the conduction ability of peripheral nerves and may have a nerve‐ and threshold‐selective relationship with the prevalence and severity of DPN among patients with T2D.
Meeting report: Third Franco‐Japanese developmental biology meeting “New Frontiers in developmental biology: Celebrating the diversity of life”
Authors: Masayuki Oginuma , Reymann Anne‐Cécile 
Published: June 2023

SummaryThe French and Japanese Developmental Biology Societies, teaming up with Human Frontier Science Program, were eager to meet back in person in November 2022 in the lovely city of Strasbourg. Top scientists in the developmental biology field from France and Japan, but also from United States, United Kingdom, Switzerland or Germany shared their exciting science during the 4 days of this meeting. Core fields of developmental biology such as morphogenesis, patterning, cell identity, and cell state transition, notably at the single cell level, were well represented, and a diversity of experimental models, including plants, animals, and other exotic organisms, as well as some in vitro cellular models, were covered. This event also extended the scope of classic scientific gatherings for two reasons. First the involvement of artists during the preparation of the event and on site. Second, part of the meeting was open for the general public through a series of outreach events, including a music and video presentation through projection mapping at Rohan palace, as well as public lectures.