bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
Authors: El-Bassouny Dalia R. , Mansour Alyaa A. , EL-Lakany Amany S. , Ayuob Nasra N. , AbdElfattah Amany A. 
Published: February 2023

Abstract
Fenofibrate is an antilipidemic drug that increases the activity of the lipoprotein lipase enzyme thus enhancing lipolysis, however, it may cause myopathy and rhabdomyolysis in humans. Coenzyme Q10 (CoQ10) is an endogenously synthesized compound that is found in most living cells and plays an important role in cellular metabolism. It acts as the electron carrier in the mitochondrial respiratory chain. This study aimed to elucidate FEN-induced skeletal muscle changes in rats and to evaluate CoQ10 efficacy in preventing or alleviating these changes. Forty adult male rats were divided equally into four groups: the negative control group that received saline, the positive control group that received CoQ10, the FEN-treated group received FEN, and the FEN+CoQ10 group, (received both FEN followed by CoQ10 daily for 4 weeks. Animals were sacrificed and blood samples were collected to assess creatine kinase (CK). Soleus muscle samples were taken and processed for light and electron microscopic studies. This study showed that FEN increased CK levels and induced inflammatory cellular infiltration and disorganization of muscular architecture with lost striations. FEN increased the percentage of degenerated collagen fibers, and immune expression of caspase 3. Ultrastructurally, it caused degeneration of myofibrils with distorted cell organelles. Treatment with CoQ10 could markedly ameliorate these FEN-induced structural changes and mostly regain the normal architecture of muscle fibers due to its antifibrotic and antiapoptotic effects. In conclusion, treatment with CoQ10 improved muscular structure by suppressing oxidative stress, attenuating inflammation, and inhibiting apoptosis.
The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population
Authors: Lin Chien-Yu , Lee Hui-Ling , Chen Ching-Way , Wang Chikang , Sung Fung-Chang , Su Ta-Chen 
Published: February 2023

Abstract
Background
Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has been shown to decrease adiponectin levels in vitro and in vivo studies. However, the role of angiotensin I-converting enzyme (ACE) gene polymorphism and epigenetic changes in the relationship between DEHP exposure and adiponectin levels is not well understood.
Methods
This study examined the correlation between urine levels of DEHP metabolite, epigenetic marker 5mdC/dG, ACE gene phenotypes, and adiponectin levels in a sample of 699 individuals aged 12 to 30 from Taiwan.
Results
Results showed a positive relationship between mono-2-ethylhexyl phthalate (MEHP) and 5mdC/dG, and a negative association between both MEHP and 5mdC/dG with adiponectin. The inverse relationship between MEHP and adiponectin was stronger when 5mdC/dG levels were above the median, as indicated by a smaller regression coefficient (-0.095 compared to -0.049). The structural equation model (SEM) analysis indicated that MEHP has a direct inverse effect on adiponectin and an indirect effect via 5mdC/dG. Subgroup analysis revealed a negative correlation between MEHP and adiponectin in individuals with the I/I ACE genotype, but not in others.
Conclusions
In this young Taiwanese population, our findings suggest that urine MEHP levels are negatively correlated with serum adiponectin levels and that ACE gene polymorphism and epigenetic modifications may play a role in this association. Further study is needed to validate these results and determine causality.
Modelling the future of energy security and decarbonisation in Morocco using OSeMOSYS
Authors: Harland Natasha 
Published: February 2023

Abstract
Morocco’s energy system is highly dependent on imported fossil fuels, making the country susceptible to fluctuating energy prices and supply issues. Expanding local energy production from renewable sources like wind and solar and reducing imported fuels may help the country to decrease its carbon emissions at the same time as improving its energy security. This study used the Open Source Energy Modelling System (OSeMOSYS) tool to determine the optimal pathway for Morocco to accomplish these goals at least cost. The modelling results suggest that diversifying the sources of imported natural gas while expanding renewable energy deployment is the best strategy for Morocco to improve its energy security and reduce carbon emissions at lowest cost. The following recommendations will help to achieve this:

Legally binding wind power and solar PV expansion plans would
ensure that renewable energy capacity increases quickly to meet
demand for the period of 2025–2065. These plans could be modelled
after the Hawai’i Clean Energy Initiative and should be used in
negotiations with multilateral development banks to secure
international funding.
The legislative framework for feed-in tariffs proposed by
Morocco should be amended to include low-voltage power production
and introduced within the next two years. Tax-exemptions and
low-interest loans should be offered for installations of small
solar power systems.
A strategy for expanding energy storage capacity should be
developed using modelled pathways of the future energy system to
assess the storage needs. A regulatory framework for storage
providers should be included.
A time-based price system for energy consumption should be
implemented as soon as possible for electricity customers, starting
with medium to large corporate consumers first.
Investment in regasification and storage infrastructure will
help to prevent overreliance on Spain’s regasification plants.
Domestic natural gas exploration in the Tendrara and Gharb
regions and a national regulatory system for natural gas production
will stabilise its supply. Transparent financing regulations would
prevent gas production projects from halting.
The female upper reproductive tract harbors endogenous microbial profiles
Authors: Canha-Gouveia Analuce , Pérez-Prieto Inmaculada , Rodríguez Carmen Martínez , Escamez Teresa , Baños Irene Leonés , Salas-Espejo Eduardo , Prieto-Sánchez Maria Teresa , Sánchez-Ferrer Maria Luisa , Coy Pilar , Altmäe Signe 
Published: February 2023

Abstract

The female reproductive tract harbours its microbial communities (microbiota) and its composition has been associated with reproductive functions in health and disease. Endometrial microbiome (genomes of microbes) studies are in agreement that uterus possesses higher bacterial diversity and richness than the vagina (where Lactobacillus is dominating) but the knowledge of the Fallopian tubes (FT) microbiomal composition is lacking, especially in fertile women in disease-free conditions. Our study included 24 women with confirmed fertility having benign uterine pathology submitted to abdominal hysterectomy or opting for contraceptive method by tubal ligation at Hospital Clínico Universitario Virgen de la Arrixaca de Murcia (HCUVA). The microbiome of FT and endometrial samples was analyzed by 16S rRNA gene sequencing. We detected distinct microbial community profiles in the endometrial and FT samples indicating that the upper reproductive tract harbors an endogenous microbiome and in big part these two sites share the microbial profile (69% of the detected taxa). Nevertheless, 17 bacterial taxa were exclusively detected in the FT that included Enhydrobacter, Granulicatella, Haemophilus, Rhizobium, Alistipes y Paracoccus, among others, while 10 were found only in the endometrium, including Klebsiella, Olsenella, Oscillibacter and Veillonella (FDR <0.05). Further, our study shows that the endometrial collection method influences the findings, where Lactobacillus dominated in the samples obtained transcervically (vaginal contamination is suspected), while Acinetobacter, Arthrobacter, Coprococcus, Methylobacterium, Prevotella, Roseburia, Staphylococcus, Streptococcus were more abundant when sampling was performed directly from the uterus at hysterescopy. Although the upper reproductive tract seems to be a low microbial biomass site, our results suggest that the endometrial and FT microbiome is unique for each individual. In fact, samples obtained from the same individual from the endometrium and FT demonstrated more microbial similarity than for the same tissue (endometrium or FT) from two different women. Unraveling the female upper reproductive microbiome helps to understand the natural microenvironment in the tissues where the first processes of oocyte fertilization and embryo development and implantation are taking place and could therefore be used for improving in vitro fertilization and embryo culture conditions in treating infertile patients.
Practical aspects of regulating the chromatic indices of rosé sparkling wine by expedition liqueur with the use of sulphiting agents
Authors: V.Taranenko  
Published: February 2023

Abstract
Chromaticity is a musical and colour synaesthesia, due to which the taster builds an associative row at the first meeting with the sparkling wine. The so-called "crunching" sound reproduced by the bursting bubbles on the surface of the sparkling wine poured into the glass presupposes a chromatic reference of the colour palette. A study of the effect of expedition liqueur on the colour change of rosé sparkling wine was carried out and it was found that the colour gradient is directly affected by expedition liqueur. Experimental samples of sparkling wine and expedition liqueur were prepared according to the classical production technology. The dosage technology involves the addition of sulphite components which protect the finished sparkling wine from oxidation. Sulphur dioxide, like tannins, are natural antiseptics. The highest levels of added sulphites are found in wines with the lowest tannin content. Correspondingly white and rosé wines have a high level of sulphites, as they are very delicate. The chromatic values of the test samples, in which sulphated forwarding liquor from 4 g/dm3 to 50 g/dm3 was added, had changes of colour from soft pink to honeydew. The pink overtones in these experimental samples are possible due to the binding of pigments with bisulphite. The chromatic values of the test samples, to which unsulphitised expedition liquor from 4 g/dm3 to 50 g/dm3 was added, had a clear shade gradient from the colour of the thigh of the frightened native nymph to the colour of the acaju. Without the addition of sulphiting agents, the colour palette changed consistently and homogeneously.
Subtype classification and prognosis of diffuse large B-cell lymphoma based on variable importance analysis
Authors: Gao Qian , Hao Ting , Zhang Huifang , Chen Shuting , Xi Yanfeng , Guan Hongwei , Wang Tong 
Published: February 2023

Abstract
Background: Gene expression profiling (GEP) is considered as gold standard for cell-of-origin (COO) classification of diffuse large B-cell lymphoma (DLBCL). However, the high dimensionality of GEP limits its application in clinical practice.
Methods: In this study, we aim to develop a parsimonious model based on GEP to accurately predict COO subtype of DLBCL for clinical applications. We first proposed a variable important measure to solve the instability of penalized regression methods in high-dimensional settings. Then this strategy was applied to six penalized methods to identify a small gene subset for DLBCL classification. Using a training dataset of 350 DLBCL patients, we developed a six-gene model for DLBCL classification. For training and validation datasets, model evaluations showed the six-gene model performed well in terms of discrimination, calibration and clinical usefulness. Subgroups of patients characterized by these six genes showed significantly different prognosis. Furthermore, model comparisons demonstrated that the six-gene model outperformed models constructed by typical penalized regression methods.
Results: In this study, we applied the above strategies for DLBCL classification analysis. Finally, six genes were identified as an optimal gene subset for both subtype classification and survival prediction in DLBCL. The predictive and prognostic performances of those six genes were further validated in the external dataset. What’s more, taking simplicity and predictability of clinical models into consideration, we found that the six-gene model outperformed the typically penalized regression models.
Conclusions: In conclusion, the six genes had considerable clinical usefulness in DLBCL classification and prognosis. The genes order based on their importance provided a priority for further functional and targeted drug research.
Retracted: Integrated modeling of food–water–energy nexus for maximizing water
productivity
Authors: Khayatnezhad Majid , Fataei Ebrahim , Imani Aliakbar 
Published: February 2023

ABSTRACT
One of the needs of a sustainable decision-making system in agriculture is to determine the role of energy in the food production cycle. Wind energy turbines can be built in agricultural fields for groundwater exploitation and reduce the cost of energy supply for the pumping system. This study was conducted to evaluate the effect of wind energy and economics on sustainable planning of agricultural water resources. A multiobjective framework was developed based on the nondominated sorting principle and water cycle optimizer. Maximization of benefit per cost ratio for the total cropping pattern and minimization of energy consumption for the growing season were addressed as the objectives of the nonlinear problem. The prediction of biomass production was made by simulating a hybrid structure between the soil moisture balance in the root zone area and the development of the canopy cover of each crop. The results showed that the objectives of the problem have been met by irrigation planning using climatic constraints and drought stresses. About 35% of the total water requirement of plants with a higher harvest index (watermelon, melon, etc.) is in the maturing stage of the shade cover.
Research Progress in Small Molecules as Anti-vitiligo Agents
Authors: Wu Heng , Niu Chao , Aisa Haji Akber 
Published: February 2023

Abstract:Vitiligo is a disease characterized by skin discoloration, and no safe and effective drugs have been developed until now. New drug research and development are imminent. This article reviews the research on small-molecule drugs for vitiligo from 1990 to 2021 at home and abroad. They are classified according to their structures and mechanisms of action, including natural products and derivatives, anti-oxidative stress drugs, immunosuppressants, prostaglandins, etc. The research on their anti-vitiligo activity, structural modification, new dosage forms, clinical trials, and the development trend in new anti-vitiligo drugs are reviewed, which provides important references for the development of new drugs.
A Systematic Review and Meta-analysis of the Effects of Topical Tranexamic
Acid versus Topical Vasoconstrictors on the Management of Epistaxis
Authors: Zhuang Chunlin , Liu Huanhai , Li Tengfei , Li Fengzhen , Cha Xudong , Wang Shenglei , Yan Jianyu , Wang Tianyu , Liang Caiquan , Ren Wenwen 
Published: February 2023

Objective:
We aimed to evaluate the effectiveness of topical tranexamic acid (TXA) versus topical vasoconstrictors in the management of epistaxis via a systematic review and meta-analysis.

Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were followed for the meta-analysis. We systematically searched Embase, Web of Science, Cochrane Library, CNKI, and PubMed for randomized controlled trials (from inception to August 2022; no language restrictions), comparing the effect of topical TXA and topical vasoconstrictors on the treatment of epistaxis. The Q test was used to evaluate heterogeneity, and funnel plots were utilized to identify bias. For the meta-analysis, the fixed-effects model was employed, and the t-test was utilized to determine significance.

Results:
Of 1012 identified studies, 5 were found to be eligible for our analysis. In total, 598 patients were included; 297 of them received TXA and 301 received vasoconstrictors. Hemostasis was more likely to be achieved at the first re-assessment in patients treated with TXA. Subgroup analysis indicated patients treated with TXA to have less likelihood of bleeding recurrence, compared to patients treated with vasoconstrictors. The detected time interval of rebleeding was 10 min, between 24h to 72h, and after 7 days, respectively, and the differences were significant between the two groups of patients treated with TXA and vasoconstrictors.

Conclusion:
Topical TXA was associated with better post-treatment hemorrhagic arrest rates compared to topical vasoconstrictors in the management of epistaxis.
Identification of Drug Targets and Agents Associated with Hepatocellular
Carcinoma through Integrated Bioinformatics Analysis
Authors: Hossen Md. Alim , Reza Md. Selim , Harun-Or-Roshid Md. , Islam Md. Ariful , Siddika Mst. Ayesha , Mollah Md. Nurul Haque 
Published: February 2023

Background:
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related
death globally. The mechanisms underlying the development of HCC are mostly unknown till now.

Objective:
The main goal of this study was to identify potential drug target proteins and agents for the
treatment of HCC.

Methods:
The publicly available three independent mRNA expression profile datasets were downloaded
from the NCBI-GEO database to explore common differentially expressed genes (cDEGs) between
HCC and control samples using the Statistical LIMMA approach. Hub-cDEGs as drug targets highlighting
their functions, pathways, and regulators were identified by using integrated bioinformatics
tools and databases. Finally, Hub-cDEGs-guided top-ranked drug agents were identified by molecular
docking study for HCC.

Results:
We identified 160 common DEGs (cDEGs) from three independent mRNA expression datasets
in which ten cDEGs (CDKN3, TK1, NCAPG, CDCA5, RACGAP1, AURKA, PRC1, UBE2T,
MELK, and ASPM) were selected as Hub-cDEGs. The GO functional and KEGG pathway enrichment
analysis of Hub-cDEGs revealed some crucial cancer-stimulating biological processes, molecular functions,
cellular components, and signaling pathways. The interaction network analysis identified three
TF proteins and five miRNAs as the key transcriptional and post-transcriptional regulators of HubcDEGs.
Then, we detected the proposed Hub-cDEGs guided top-ranked three anti-HCC drug molecules
(Dactinomycin, Vincristine, Sirolimus) that were also highly supported by the already published
top-ranked HCC-causing Hub-DEGs mediated receptors.

Conclusion:
The findings of this study would be useful resources for diagnosis, prognosis, and therapies
of HCC.
Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A
Decade's Worth of Evolution
Authors: Murugesan Sankaranarayan , Chandra Sekhar Kondapalli Venkata Gowri , Jadhav Snehal Rajkumar , Karan Kumar Banoth , Joshi Renuka Parshuram , Suryakant Chougule Kishor , Chandu Ala , Muzaffar-Ur-Rehman Mohammed , Khetmalis Yogesh Mahadu , Nandikolla Adinarayana 
Published: February 2023

Abstract:
Tropical, vector-borne, and neglected diseases with a limited number of medication ther-apies include Leishmaniasis, Malaria, Chagas and Human African Trypanosomiasis (HAT). Chro-mones are a large class of heterocyclic compounds with significant applications. This heterocycle has long aroused the interest of scientists and the general public from biosynthetic and synthetic points of view owing to its interesting pharmacological activities. Chromones and their hybrids and isomeric forms proved to be an exciting scaffold to investigate these diseases. The in vitro activities of Chromone, Chromane, and a panel of other related benzopyran class compounds against Trypa-nosoma brucei rhodesiense, Trypanosoma brucei gambiense, Trypanosoma cruzi, and numerous Leishmanial and Malarial species were investigated in our previous studies. The current article briefly describes the neglected diseases and the current treatment. This review aims to attempt to find better alternatives by scrutinizing natural and synthetic derivatives for which chromones and their analogues were discovered to be a new and highly effective scaffold for the treatment of ne-glected diseases, including compounds with dual activity or activity against multiple parasites. Ad-ditionally, the efficacy of other new scaffolds was also thoroughly examined. This article also dis-cusses prospects for identifying more unique targets for the disease, focusing on flavonoids as drug molecules that are less cytotoxic and high antiprotozoal potential. It also emphasizes the changes that can be made while searching for potential therapies-comparing existing treatments against pro-tozoal diseases and the advantages of the newer chromone analogues over them. Finally, the struc-ture-activity relationship at each atom of the chromone has also been highlighted.
Synthesis of 4-Pyridinylquinolines via Sugasawa and Friedlander Reaction from 4-Cyanopyridine with Anilines and Ketones
Authors: Liu Chi , Yang Zhilin , Ji Jiangyu , Li He , Man Lili , Li Runlai , Zhang Zhenming 
Published: February 2023

Abstract:
Firstly, 2-amino aromatic ketones were synthesized by o-acylation of p-substituted anilines
with nitrile under Sugasawa conditions, and the yield was up to 90.1%. Then, 4-pyridinylquinoline derivatives
were synthesized by Friedlander reaction with α-methylene ketones, and the yield was up to
81.9%. The structures of five 2-amino aromatic ketones and eighteen substituted quinolines were
characterized by MS, 1H NMR, and 13C NMR. The structures were further confirmed by single crystal
X-ray diffraction, which was consistent with the expected structures. Analyzing the crystal structure,
it was found that compounds 4j and 4q crystallized in the monoclinic with the P21/n space group, respectively.
Compounds 2c, 2d, 2e, and 4n crystallized in the triclinic with the P-1 space group, respectively.
Of which compound 4n crystallized in the triclinic space group P-1 with two crystallographically
independent but chemically equivalent molecules in the asymmetric unit. The two independent
molecules were found to possess different orientations of the chlorine, methyl, pyridyl, and
acetyl groups relative to the core (quinoline) two-ring system. This work provides a simple, straightforward
synthetic protocol for preparing 4-pyridinylquinoline derivatives.