bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-based assessment of sarcopenia for differentiating wild-type from mutant-type gastrointestinal stromal tumor
Authors: Yi Xiaoping , Zhou Gaofeng , Fu Yan , Wu Jinchun , Chen Changyong , Zai Hongyan , He Qiongzhi , Pang Peipei , Zhou Haiyan , Gong Guanghui , Lei Tianxiang , Tan Fengbo , Liu Heli , Li Bin , Chen Bihong T. 
Published: February 2023

AbstractNon-invasive prediction for KIT/PDGFRA status in GIST is a challenging problem. This study aims to evaluate whether CT based sarcopenia could differentiate KIT/PDGFRA wild-type gastrointestinal stromal tumor (wt-GIST) from the mutant-type GIST (mu-GIST), and to evaluate genetic features of GIST. A total of 174 patients with GIST (wt-GIST = 52) were retrospectively identified between January 2011 to October 2019. A sarcopenia nomogram was constructed by multivariate logistic regression. The performance of the nomogram was evaluated by discrimination, calibration curve, and decision curve. Genomic data was obtained from our own specimens and also from the open databases cBioPortal. Data was analyzed by R version 3.6.1 and clusterProfiler (http://cbioportal.org/msk-impact). There were significantly higher incidence (75.0% vs. 48.4%) and more severe sarcopenia in patients with wt-GIST than in patients with mu-GIST. Multivariate logistic regression analysis showed that sarcopenia score (fitted based on age, gender and skeletal muscle index), and muscle fat index were independent predictors for higher risk of wt-GIST (P < 0.05 for both the training and validation cohorts). Our sarcopenia nomogram achieved a promising efficiency with an AUC of 0.879 for the training cohort, and 0.9099 for the validation cohort with a satisfying consistency in the calibration curve. Favorable clinical usefulness was observed using decision curve analysis. The additional gene sequencing analysis based on both our data and the external data demonstrated aberrant signal pathways being closely associated with sarcopenia in the wt-GIST. Our study supported the use of CT-based assessment of sarcopenia in differentiating the wt-GIST from the mu-GIST preoperatively.
Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer
Authors: Wang Lucy , Evans James C. , Ahmed Lubabah , Allen Christine 
Published: February 2023

AbstractCombination chemotherapy is an established approach used to manage toxicities while eliciting an enhanced therapeutic response. Delivery of drug combinations at specific molar ratios has been considered a means to achieve synergistic effects resulting in improvements in efficacy while minimizing dose related adverse drug reactions. The benefits of this approach have been realized with the FDA approval of Vyxeos®, the first liposome formulation to deliver a synergistic drug combination leading to improved overall survival against standard of care. In the current study, we demonstrate the synergistic potential of the PARP inhibitor niraparib and doxorubicin for the treatment of ovarian cancer. Through in vitro screening in a panel of ovarian cancer cell lines, we find that niraparib and doxorubicin demonstrate consistent synergy/additivity at the majority of evaluated molar ratio combinations. Further to these findings, we report formulation of a nanoparticle encapsulating our identified synergistic combination. We describe a rational design process to achieve highly stable liposomes that are targeted with folate to folate-receptor-alpha, which is known to be overexpressed on the surface of ovarian cancer cells. With this approach, we aim to achieve targeted delivery of niraparib and doxorubicin at a pre-determined synergistic molar ratio via increased receptor-mediated endocytosis.
Cluster-based psychological phenotyping and differences in anxiety treatment outcomes
Authors: Taylor Veronique A. , Roy Alexandra , Brewer Judson A. 
Published: February 2023

AbstractThe identification of markers of mental health illness treatment response and susceptibility using personalized medicine has been elusive. In the context of psychological treatment for anxiety, we conducted two studies to identify psychological phenotypes with distinct characteristics related to: psychological intervention modalities (mindfulness training/awareness), mechanism of action (worry), and clinical outcome (generalized anxiety disorder scale scores). We also examined whether phenotype membership interacted with treatment response (Study 1) and mental health illness diagnosis (Studies 1–2). Interoceptive awareness, emotional reactivity, worry, and anxiety were assessed at baseline in treatment-seeking individuals (Study 1, n = 63) and from the general population (Study 2, n = 14,010). In Study 1, participants were randomly assigned to an app-delivered mindfulness program for anxiety for two months or treatment as usual. Changes in anxiety were assessed 1 and 2 months post-treatment initiation. In studies 1–2, three phenotypes were identified: ‘severely anxious with body/emotional awareness’ (cluster 1), ‘body/emotionally unaware’ (cluster 2), and ‘non-reactive and aware’ (cluster 3). Study 1’s results revealed a significant treatment response relative to controls (ps < 0.001) for clusters 1 and 3, but not for cluster 2. Chi-square analyses revealed that phenotypes exhibited significantly different proportions of participants with mental health diagnoses (studies 1–2). These results suggest that psychological phenotyping can bring the application of personalized medicine into clinical settings.Registry name and URL: Developing a novel digital therapeutic for the treatment of generalized anxiety disorder https://clinicaltrials.gov/ct2/show/NCT03683472?term=judson+brewer&draw=1&rank=1.Trial registration: Registered at clinicaltrials.gov (NCT03683472) on 25/09/2018.
Implementation and performance analysis of QPSK system using pocket double gate asymmetric JLTFET for satellite communications
Authors: Boggarapu Lokesh , B Lakshmi 
Published: February 2023

AbstractThis work is intended to design a quadrature phase shift keying (QPSK) system starting from the device design, characterization and optimization which is then followed by the circuit level implementation and finally the system level configuration. Tunnel Field Effect Transistor (TFET) technology came into existence because of the inability of CMOS (Complementary Metal Oxide Semiconductor) to produce reduced leakage current (Ioff) in the subthreshold regime. With the effects of scaling and requirement of high doping concentrations, TFET is not capable to produce stable reduction in Ioff due to the variation in ON and OFF current. To improve the switching ratio of the current and to obtain good subthreshold swing (SS) by overcoming the limitations of junction TFET, a new device design is proposed for the first time in this work. A pocket double gate asymmetric Junction less TFET (poc-DG-AJLTFET) structure has been proposed in which uniform doping is used to eliminate the junctions and a pocket of length 2 nm made of Silicon–Germanium (SiGe) material has been introduced to improve the designed structure performance in the weak inversion region and increase the drive current (ION). The work function has been tuned to produce the best results for poc-DG-AJLTFET and with our proposed poc-DG-AJLTFET, effects of interface traps are eliminated as against conventional JLTFET structures. The notion that low-threshold voltage device yields high IOFF has been proved wrong with our poc-DG-AJLTFET design, as it produced low threshold voltage with lower IOFF which reduced the power dissipation. Numerical results show that drain induced barrier lowering (DIBL) of 2.75 mV/V is achieved which could be less than 35 times required for short channel effects to be minimum. In terms of gate to drain capacitance (Cgd), it is found that ~ 103 reduction which greatly improves device inertia to internal electrical interference. Also, improvement in transconductance is achieved by 104 times, 103 times improvement in ION/IOFF ratio, and 400 times higher unity gain cutoff-frequency (ft) which would be required by all communication systems. The Verilog models of the designed device are used to construct the leaf cells of quadrature phase shift keying (QPSK) system and the implemented QPSK system is taken as a key evaluator in the performance evaluation in terms of propagation delay and power consumption of poc-DG-AJLTFET in modern satellite communication systems.
Two-year outcomes of treat-and-extend regimen with intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 macular neovascularization
Authors: Matsumoto Hidetaka , Hoshino Junki , Nakamura Kosuke , Akiyama Hideo 
Published: February 2023

AbstractWe previously reported one-year results of a treat-and-extend (TAE) regimen with intravitreal brolucizumab for 68 eyes with treatment-naïve neovascular age-related macular degeneration (nAMD) associated with type 1 macular neovascularization (MNV). In the current study, we evaluated second-year results of the brolucizumab TAE therapy in 45 eyes with type 1 MNV that had completed the first-year treatment. Forty-three eyes (95.6%) received brolucizumab TAE treatment during a period of 96 weeks. The significant improvement of best-corrected visual acuity in the first year was maintained in the second year. Moreover, the significant foveal thickness and central choroidal thickness reductions in the first year were maintained in the second year. The total number of injections over the 96-week study period was 10.0 ± 1.4, with 6.4 ± 0.6 in the first year and 3.6 ± 1.0 in the second year. The intended injection interval at week 96 was 8 weeks in 9 eyes (20.9%), 12 weeks in 3 eyes (7.0%), and 16 weeks in 31 eyes (72.1%), with an average injection interval of 14.0 ± 3.3 weeks. No eyes developed brolucizumab-related intraocular inflammation (IOI) during the second-year treatment. These results indicate that the TAE regimen with intravitreal brolucizumab for treatment-naïve nAMD associated with type 1 MNV effectively maintained the improved visual acuity and the diminished exudative changes in the second year. Moreover, intravitreal brolucizumab has the potential to reduce the treatment burden of nAMD. The risk of developing brolucizumab-related IOI appeared to be very low during the second year of this TAE regimen.
Formulas calculating the reactance of tubular busbars and their derivation in primary electrical connection schemes
Authors: Ge Qun , Li Zaiqiang , Liu Siyuan , Xing Jiaqi 
Published: February 2023

AbstractElectrical switching operation in a substation which locates in a high-voltage transmission system alters operating modes of main wiring in either the substation or the system. Major alterations may have negative influences on the switchgear of main wiring in a short time. The quantitative study of this problem has to be based on establishing equivalent circuits of main wiring, when there rarely are formulas to calculate the reactance of tubular busbars. In this paper on the basis of the electromagnetic field theory, the magnetic induction and flux linkages outside and inside tubular conductors are obtained from the Ampere Loop Theorem, and then the formulas to calculate approximately the reactance of tubular busbars with a three-phase parallel arrangement are derived. From the process and results of the calculation in an example it may be seen that the formulas are applied simply, conveniently and rapidly, and may be valuably spread in practical electrical engineering.
„Ist es ein Junge oder ein Mädchen?“ – und was diese Frage für Betroffene bedeutet
Authors: Stoltze Anette , Gesing Julia , Stein Robert , Sergeyev Elena , Göpel Eric , Pfäffle Roland , Kiess Wieland 
Published: February 2023

ZUSAMMENFASSUNGVarianten der Geschlechtsentwicklung erfahren in der aktuellen Zeit einen immer größeren Interessenszuwachs, nicht zuletzt auch durch das große mediale Interesse der „LGBTQIA-Bewegung“ und dem daraus resultierenden offeneren Umgang mit Personen, die nicht in das klassische Bild einer Frau oder eines Mannes passen. Dies zeigt sich insbesondere durch den Wandel der Begrifflichkeiten von „intersexuell“ über „Störungen“ hin zu „Varianten der Geschlechtsentwicklung“ sowie auch durch die Einführung des 3. Geschlechts „divers“ im Jahr 2018. Die Tatsache, dass im Jahr 2021 weltweit jedoch lediglich 96 Personen als „divers“ registriert waren, macht die Diskrepanz zwischen großem Interesse auf der einen und Stigmatisierungsangst auf der anderen Seite deutlich. Eine ähnliche Berührungsangst erleben wir auch im klinischen Alltag. Ursächlich für diese Berührungsangst sind häufig eine ungenaue Vorstellung des Krankheitsbildes sowie die Sorge in der Diagnostik und Betreuung der Betroffenen und deren Familien, Fehler zu begehen. Diese Übersicht soll helfen, das Thema „Varianten der Geschlechtsentwicklung“ besser zu verstehen, die Unterschiede der einzelnen Formen aufzuzeigen, eine Orientierung in der Diagnostik zu bieten, sowie insbesondere die Besonderheiten in der Begleitung und einer potenziellen Therapie aufzuzeigen.
Vegetarisch, vegan oder adipös?
Authors: Kapellen Sibylle , Thiele Alena 
Published: February 2023

ZUSAMMENFASSUNGEine vegetarische oder vegane Ernährung ist weniger klimaschädlich und verbraucht weniger Ressourcen als eine Ernährung mit viel Fleisch. Diese Tatsache ist mittlerweile allgemein anerkannt. Aber können diese Kostformen auch ein Mittel im Kampf gegen Adipositas sein? Wie sicher sind sie für Kinder und Jugendliche mit ihrem hohen Nährstoff- und Energiebedarf? Auf diese Frage gibt es nach aktueller Studienlage keine klaren Antworten. VeganerInnen und VegetarierInnen sind tendenziell leichter als Mischköstler, haben aber ein höheres Risiko einer Mangelernährung. Welchen Beitrag die neuen Fleisch- und Milchersatzprodukte zur Energie- und Nährstoffzufuhr leisten, wurde noch nicht hinreichend untersucht.Grundsätzlich ist ein umfängliches Ernährungswissen Voraussetzung, um eine vegetarische oder vegane Ernährung bedarfsdeckend und gesundheitsfördernd zu gestalten.
Large-eddy simulation of a hypersonic turbulent boundary layer over a compression corner
Authors: Qi Han , Li Xinliang , Ji Xiangxin , Tong Fulin , Yu Changping 
Published: February 2023

In this paper, large-eddy simulation of the interaction between a shock wave and the hypersonic turbulent boundary layer in a compression corner with a fixed 34° deflection angle at Ma = 6 for different Reynolds number cases is conducted. For investigating the effects of the Reynolds number for hypersonic cases, three cases where the free-stream Reynolds numbers are 14000, 20000, and 30000/mm are selected. The averaged statistics, such as the mean velocity, the skin friction, the heat flux, and the wall pressure, are used in this paper. The flow structures in the compression ramp including the shock wave and interaction region are discussed. The decomposition of the mean skin-friction drag for the flat flow is extended to be used in the compression corner. In addition, the turbulent kinetic energy is studied through the decomposition of the mean skin-friction drag for the flat-plate region and the corner region. It is found that higher Reynolds numbers would increase the turbulent kinetic energy by turbulent dissipation at the interaction region, while higher Reynolds numbers would decrease the turbulent kinetic energy by turbulent dissipation after reattachment. In addition, it is also found that the turbulent kinetic energy is larger with a higher Reynolds number and higher turbulent kinetic energy inhibits the movement from the separation point to the inflection point (x = 0 mm), which deduces larger separation bubbles.
Magnetic properties deterioration of non-oriented steel due to laser cutting
Authors: Zhang Changgeng , Zhang Yan , Li Yongjian , Yang Qingxin 
Published: February 2023

In the manufacturing process of electrical machines, laser cutting is widely used to produce the laminations of cores. The internal stresses introduced by the high-energy laser beam will lead to deterioration in the magnetic properties of the non-oriented silicon steels. To accurately predict the core losses of the electrical machines, it is important to analyze the deterioration degree and the deterioration mechanism of the non-oriented steel sheets caused by laser cutting. In this paper, first, the local magnetic properties of the non-oriented steel 35WW250 at different positions are measured under the alternating sinusoidal excitation, in which the degradation degree is evaluated based on the core loss from the macroscopic perspective. Second, from the microscopic perspective, the observed magnetic domain patterns at the edge and those evolutions under the excitation of the magnetic field are investigated. The experimental results demonstrate that laser cutting can lead to the magnetic degradation of the non-oriented steels with a transverse depth of 18 mm from the edge. Moreover, the laser cutting process leads to significant variations in the patterns of the magnetic domains at different positions. The magneto-optical observation and local magnetic measurement verified the effectiveness of the analytical method, which is of great significance for the evaluation and improvement of the processing technique of the silicon steels.
economy is human
Authors: Xu Yuting , Royce Terry , Hu Chunyu 
Published: February 2023

Abstract
Utilizing the framework of Extended Conceptual Metaphor Theory (ECMT), this paper presents a corpus-based multi-level comparative study of the economy is human metaphor in English and Chinese economic media discourse. While the results indicate a considerable sharing of their respective conceptual structures of “human body”, “human condition” and “human relationship”, they do reveal some differences in terms of their preference and the associated metaphorical expressions. The similarities detected can possibly be attributed to the similar body, physiological function and social attributes all human beings share, which then work as the source for drawing inferences about the economy. The differences however are also likely to be derived from the different saliences of human experience which characterize the English and Chinese social-cultural contexts. Another possible explanation for these differing culturally-sourced linguistic metaphors may well be media language and its idiosyncratic stylistic features.
Effects of far‐infrared radiation lamp therapy on recovery from muscle damage induced by eccentric exercise
Authors: Chen Trevor C. , Huang Yuh‐Chuan , Chou Tai‐Ying , Hsu Sheng‐Tsung , Chen Mei‐Yen , Nosaka Kazunori 
Published: February 2023

ABSTRACTThe present study investigated the effects of a far‐infrared radiation (FIR) lamp therapy on changes in muscle damage and proprioception markers after maximal eccentric exercise of the elbow flexors (EF: Study 1) and the knee flexors (KF: Study 2) in comparison to a sham treatment condition. In each study, 24 healthy sedentary women were assigned to a FIR or a sham treatment group (n = 12/group). They performed 72 maximal EF eccentric contractions (Study 1) or 100 maximal KF eccentric contractions (Study 2) with their non‐dominant limbs. They received a 30‐min FIR (wavelength: 8–14 µm) or sham treatment at 1, 25, 49, 73 and 97 h post‐exercise to the exercised muscles. Maximum voluntary isometric contraction (MVC) torque, muscle soreness, plasma creatine kinase activity, and proprioception assessed by position sense, joint reaction angle, and force match were measured before, and 0.5, 24, 48, 72, 96 and 120 h post‐exercise. The outcome measures showed significant changes (P < 0.05) at 0.5‐hour post‐exercise (before treatment) similarly (P > 0.05) between the conditions in both studies. However, changes in all measures at 24–120 h post‐exercise were smaller (P < 0.05) for the FIR than sham condition in both studies. For example, MVC torque returned to the baseline by 72 h post‐exercise for the FIR condition in both studies, but was still 19 ± 6% (Study 1) or 17 ± 12% (Study 2) lower than the baseline at 120 h post‐exercise for the sham condition. These results suggested that the FIR lamp therapy was effective for accelerating recovery from muscle damage.
A brief review of novel nucleic acid test biosensors and their application prospects for salmonids viral diseases detection
Authors: Liu Xiaofei , Qiu Songyin , Fang Haiping , Mei Lin , Jing Hongli , Feng Chunyan , Wu Shaoqiang , Lin Xiangmei 
Published: February 2023

Abstract
Viral diseases represent one of the major threats for salmonids aquaculture. Early detection and identification of viral pathogens is the main prerequisite prior to undertaking effective prevention and control measures. Rapid, sensitive, efficient and portable detection method is highly essential for fish viral diseases detection. Biosensor strategies are highly prevalent and fulfill the expanding demands of on-site detection with fast response, cost-effectiveness, high sensitivity, and selectivity. With the development of material science, the nucleic acid biosensors fabricated by semiconductor have shown great potential in rapid and early detection or screening for diseases at salmonids fisheries. This paper reviews the current detection development of salmonids viral diseases. The present limitations and challenges of salmonids virus diseases surveillance and early detection are presented. Novel nucleic acid semiconductor biosensors are briefly reviewed. The perspective and potential application of biosensors in the on-site detection of salmonids diseases are discussed.
Energy Power Series Analysis of the Bound States of the One-dimensional Dirac Equation
Authors: Barrera-Figueroa V 
Published: February 2023

Abstract
In this work we consider the one-dimensional Dirac equation including an electrostatic potential with compact support, and focus on the regime of bound states. We obtain exact expressions for both the characteristic function and the eigenfunctions in L
2 (ℝ, ℂ2), given in the form of power series of the energy parameter. This approach is meant for arbitrary bounded potentials, so that a square potential is a special case of the theory here presented. We derive an efficient numerical method for the calculation of approximate eigen-energies of the bound states. Finally, we investigate the physical sense of the eigen-energies that are forbidden in the non-relativistic regime in terms of the Klein tunneling.
Global and Bipartite Entanglement for Three-Qubit System Local Unitary Classes
Authors: Luna-Hernández S 
Published: February 2023

Abstract
Entanglement of multipartite quantum systems is an important resource in the field of quantum information processing. Using a measure of global entanglement and the notion of concurrence, the properties of entanglement for a three-qubit system are studied and classified in terms of local unitary classes. The connection of such classification with the three-qubit entanglement polytope is also discussed.
Study of the Lennard-Jones and H2 potentials in the framework of the Morse based algebraic DVR approach
Authors: Rodríguez-Arcos M , Bermúdez-Montaña M , Lemus R 
Published: February 2023

Abstract
We propose a method based on an algebraic discrete variable representation (DVR) of the coordinate and momentum in the scheme of complete basis related to the 1D Morse potential, with this approach, a Hamiltonian associated to a 1D system can be expressed in terms of diagonal matrices using the transformation coefficients and the diagonalization of the matrix representation of the coordinate and momentum. We probe the scope of our method obtaining the solutions associated of the Lennard-Jones potential, also we apply the method to a practical example considering the ab initio potential of the H2 molecule. For both cases, the vibrational energies and the wave functions were obtained with good accuracy and low computational cost.