bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the COVID‐19 pandemic on epidemiology, treatment, and outcome of major trauma in Japan in 2020: a retrospective observational nationwide registry‐based study
Authors: Ojima Masahiro , Ishida Kenichiro , Katayama Yusuke , Hirose Tomoya , Nakao Shunichiro , Tachino Jotaro , Noda Tomohiro , Umemura Yutaka , Kiguchi Takeyuki , Kiyohara Kosuke , Matsuyama Tasuku , Kitamura Tetsuhisa , Oda Jun , Ohnishi Mitsuo 
Published: January 2023

AimThe nationwide impact of the coronavirus disease (COVID‐19) pandemic on major trauma in Japan is unknown. The nationwide registry‐based data of the Japanese Trauma Data Bank were analyzed to elucidate the impact of COVID‐19 on the epidemiology, treatment, and outcomes of major trauma patients.MethodsAmong patients transported directly from the injury site by ambulance with an Injury Severity Score of ≥16, we compared patients managed from April to December in 2019 to those managed from April to December in 2020.ResultsIn total, 9792 patients were included in this study (2019, n = 5194; 2020, n = 4598). There were no significant differences in age or sex, but there were significant differences between 2019 and 2020 in the rates of “self‐injury (suicide)”, “motor vehicle accident”, “fall from height”, “fall down”, and “fall to the ground”, which are factors associated with patient age. Injury severity in 2019 and 2020 did not differ to a statistically significant extent, but the rate of major spinal injury increased. The time of prehospital care significantly increased in 2020 compared to 2019. There was no noticeable change in hospital treatment or in‐hospital mortality between 2019 and 2020.ConclusionThis study suggests that the COVID‐19 pandemic might have altered the injuries of major trauma; however, medical services for major trauma were well supplied in Japan in 2020.
Alcoholic liver disease in relation to cancer incidence and mortality: Findings from a large, matched cohort study in South Korea
Authors: Tran Thi Phuong Thao , Han Minji , Luu Ngoc Minh , Oh Jin‐Kyoung 
Published: January 2023

AbstractAimTo estimate the risk of cancer incidence and mortality among patients with alcoholic liver disease in South Korea.MethodsA matched cohort study was conducted, including 1,042,185 men (alcoholic liver disease cases: 208,437; controls: 833,748) and 100,400 women (alcoholic liver disease cases: 20,080; controls: 80,320), matched for sex, age, smoking, alcohol consumption, and body mass index at a 1:4 ratio. The risk of cancer incidence and mortality in the alcoholic liver disease group was assessed using Cox proportional hazards regression models.ResultsBoth men and women with alcoholic liver disease had an elevated risk of all‐cancer and liver cancer incidence and mortality in comparison with the control group. In men, alcoholic liver disease was associated with a significantly higher risk of development of 10 cancer types, including lip, oral cavity, and pharynx; esophagus; liver; gallbladder and biliary tract; pancreas; larynx; lung; kidney; thyroid gland; and leukemia. Subgroup analysis by hepatitis B and C infection showed increased hazard ratios of all cancer incidences and mortality in the alcoholic liver disease group, regardless of hepatitis B or C infection status. In both sexes, a higher number and more years of hospital or clinic visits for alcoholic liver disease were associated with an increased risk of incidence and mortality from all cancers and liver cancer. A more profound dose–response relationship between alcoholic liver disease and alcohol consumption was observed in women than in men.ConclusionsOur findings emphasize the need for a clinical surveillance program and the early detection of cancer in patients with alcoholic liver disease.
Corporate social responsibility and behavioral intentions: A mediating mechanism of Brand Recognition
Authors: Singh Varsha , Kathuria Sakshi , Puri Deepika , Kapoor Bharat 
Published: January 2023

AbstractIn recent years, corporate social responsibility (CSR) has attracted a lot of attention from academics and businesspeople as an essential part of any company's ability to thrive. Many research papers had published focusing on CSR. However, very few studies examine CSR's multidimensions (economic, philanthropic, environmental, and ethical) on behavioral intentions with the mediating impact of brand recognition. To explore customer's hotel experiences, the proposed hypotheses were tested with a Structural equation model. Results show that all forms of CSR (ethical, economic, environmental, philanthropic) positively relate to the hotel's brand recognition and behavioral intentions (revisit intention, making recommendations, willingness to pay more). The link between CSR and behavioral intention is found to be significantly mediated by brand recognition. Because of this, the current study has developed a theoretical framework to explain the interplay among CSR factors, brand recognition, and consumer behavioral intention. By checking CSR activities' impact as a focal factor in enhancing hospitality industry facilities, this study offers empirical implications for hotels.
Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections
Authors: Heino Matti T. , Nyman Tommi , Palo Jukka U. , Harmoinen Jenni , Valtonen Mia , Pilot Małgorzata , Översti Sanni , Salmela Elina , Kunnasranta Mervi , Väinölä Risto , Hoelzel A. Rus , Aspi Jouni 
Published: January 2023

AbstractThe Saimaa ringed seal (Pusa hispida saimensis) is endemic to Lake Saimaa in Finland. The subspecies is thought to have originated when parts of the ringed seal population of the Baltic region were trapped in lakes emerging due to postglacial bedrock rebound around 9000 years ago. During the 20th century, the population experienced a drastic human‐induced bottleneck. Today encompassing a little over 400 seals with extremely low genetic diversity, it is classified as endangered. We sequenced sections of the mitochondrial control region from 60 up to 125‐years‐old museum specimens of the Saimaa ringed seal. The generated dataset was combined with publicly available sequences. We studied how genetic variation has changed through time in this subspecies and how it is phylogenetically related to other ringed seal populations from the Baltic Sea, Lake Ladoga, North America, Svalbard, and the White Sea. We observed temporal fluctuations in haplotype frequencies and loss of haplotypes accompanied by a recent reduction in female effective population size. In apparent contrast with the traditionally held view of the Baltic origin of the population, the Saimaa ringed seal mtDNA variation also shows affinities to North American ringed seals. Our results suggest that the Saimaa ringed seal has experienced recent genetic drift associated with small population size. The results further suggest that extant Baltic ringed seal is not representative of the ancestral population of the Saimaa ringed seal, which calls for re‐evaluation of the deep history of this subspecies.
Evaluate your credentials to assess whether skills are useful in the workplace, valuable to students
Authors: Sutton Halley 
Published: January 2023

CHICAGO — Can students actually demonstrate the skills they learn from your programs in a way that will better their life outcomes? And do employers understand the competencies students gain when they graduate from your institution? It's a question on the minds of many who work in higher education, and it has an impact for your institution in terms of showing students the value of their degree. The landscape of college credentials is growing, sowing further confusion as each institution often has its own language for discussing similar skills or competencies.
Investigation on quenching characteristics of parallel narrow channels for deflagration flames
Authors: Lu Yawei , Guo Pinkun , Wang Zhirong , Wang Xiangwen , Yan Chen 
Published: January 2023

AbstractA set of experimental equipment for quenching the deflagration flame in linked vessels with parallel narrow channels was proposed. The quenching effects of the deflagration flame in the linked vessels were investigated, the influence law and mechanism of parallel narrow channels on the deflagration flame was analyzed. The results showed that the Pmax and the (dP/dt)max at each position were both lower than without parallel narrow channels, which indicated that the propagation of flame was inhibited by parallel narrow channels effectively, and the explosion intensity was also reduced. The pressure oscillation phenomenon inside the linked vessels disappeared due to the inclusion of parallel narrow channels. The deflagration flame was successfully quenched when the channel gaps were 0.5, 1.5, and 3 mm, but failed to be quenched when the channel gap was 6 mm. The quenching distance and the average propagation velocity of the deflagration flame in parallel narrow channels increased with the increase of the channel gap. When the channel gap was 6 mm, the deflagration flame completely passed through parallel narrow channels, and the average propagation velocity of deflagration flame was significantly greater than that when the deflagration flame was successfully quenched.
Synthesis of novel thiazole, imidazole, benzimidazole, and benzothiazole derivatives incorporating 2‐phenoxy‐N‐arylacetamide unit as novel hybrid molecules
Authors: Diab Hadeer M. , Mohamed Dina Mamdouh , Darweesh Ahmed F. , Abdelhamid Ismail A. , Elwahy Ahmed H. M. 
Published: January 2023

AbstractNovel 2‐phenoxy‐N‐phenylacetamide hybrids with heterocyclic scaffolds such as thiazoles, imidazoles, benzimidazoles, and benzothiazoles were synthesized efficiently in this study. The reaction of the appropriate α‐haloketone with the corresponding thioamide derivatives in EtOH/DMF at reflux in the presence of a few drops of TEA produced good yields of 2‐aryl‐ or heteroarylthiazoles. A one‐pot three‐component reaction of 1,2‐diketone with aldehydes and ammonium acetate in methanol at reflux yielded imidazole derivatives. It was also feasible to synthesize benzimidazoles, benzothiazoles, or imidazo[4,5‐b]pyridines by employing the reactions of the appropriate aldehydes with o‐phenylenediamine, 2‐aminothiophenol, or 2,3‐diaminopyridine, respectively, in ethanol at reflux in the presence of NaHSO3. The new compounds' structures were validated using spectrum data and elemental analyses.
Extranodal Extension Improves AJCC‐8 Accuracy in HPV+ Oropharyngeal Cancer in a High‐Risk Population
Authors: Burruss Clayton Prakash , Sharrer Christine , Porterfield James Zachary , Kejner Alexandra Eva 
Published: January 2023

ObjectivesThe American Joint Committee on Cancer's 8th edition (AJCC‐8) separates oropharyngeal squamous cell carcinomas (OPSCCs) into human papillomavirus‐positive (HPV+) tumors and HPV‐negative tumors. Although AJCC‐8 improves prognostic prediction for survival for the majority of HPV+ OPSCC, outliers are still encountered. The goal of this manuscript is to validate the AJCC‐8 as a better metric of survivability than the AJCC‐7 in an historically under‐served rural population with confounding variables, such as tobacco use, alcohol consumption, and poor health care access and to analyze the role of extranodal extension (ENE) in this population.DesignRetrospective cohort study.ResultsCompared to AJCC‐7, AJCC‐8 had a higher odds ratio (OR) for predicting mortality of stage IV HPV+ OPSCCs versus stages I–III. On multivariate analysis, HPV+ OPSCCs with ENE had a higher OR of mortality compared to ENE‐ OPSCCs. In addition, HPV+ OPSCC patients with a Charlson Comorbidity Index (CCI) > 3 had a higher OR of mortality compared to those with a CCI ≤ 3. Patients with Medicaid/self‐pay status had a higher OR of mortality compared to those with private insurance/Medicare. Finally, patients from rural populations had a higher OR of presenting with stage IV disease, a CCI > 3, and Medicaid/self‐pay status.ConclusionsDespite not being a discrete part of the AJCC‐8 staging rubric, ENE was found to have a significant impact on mortality among this population, whereas tobacco use had no effect. Rural patients were more likely to present with stage IV disease, CCI > 3, and Medicaid/self‐pay status. Stage IV disease was also associated with a higher OR of mortality.Level of Evidence4 Laryngoscope, 133:2621–2626, 2023
Efficient Transfection via an Unexpected Mechanism by Near Neutral Polypiperazines with Tailored Response to Endosomal pH
Authors: Hausig‐Punke Franziska , Dekevic Gregor , Sobotta Fabian H. , Solomun Jana I. , Richter Friederike , Salzig Denise , Traeger Anja , Brendel Johannes C. 
Published: January 2023

AbstractCationic pH‐responsive polymers promise to overcome critical challenges in cellular delivery. Ideally, the polymers become selectively charged along the endosomal pathway disturbing only the local membrane and avoiding unintended interactions or cytotoxic side effects at physiological conditions. Polypiperazines represent a novel, hydrophilic class of pH‐responsive polymers whose response can be tuned within the relevant pH range (5–7.4). The authors discovered that the polypiperazines are effectively binding plasmid DNA (pDNA) and demonstrate high efficiency in transfection. By design of experiments (DoE), a wide parameter space (pDNA and polymer concentration) is screened to identify the range of effective concentrations for transfection. An isopropyl modified polypiperazine is highly efficient over a wide range of concentrations outperforming linear polyethylenimine (l‐PEI, 25 kDa) in regions of low N*/P ratios. A quantitative polymerase chain reaction (qPCR) surprisingly revealed that the pDNA within the piperazine‐based polyplexes can be amplified in contrast to polyplexes based on l‐PEI. The pDNA must therefore be more accessible and bound differently than for other known transfection polymers. Considering the various opportunities to further optimize their structure, polypiperazines represent a promising platform for designing effective soluble polymeric vectors, which are charge‐neutral at physiological conditions.
Dopamine Agonist Cotreatment Alters Neuroplasticity and Pharmacology of Levodopa‐Induced Dyskinesia
Authors: Espa Elena , Song Lu , Skovgård Katrine , Fanni Silvia , Cenci M. Angela 
Published: January 2023

AbstractBackgroundCurrent models of levodopa (L‐dopa)‐induced dyskinesia (LID) are obtained by treating dopamine‐depleted animals with L‐dopa. However, patients with LID receive combination therapies that often include dopamine agonists.ObjectiveUsing 6‐hydroxydopamine‐lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID‐related neuroplasticity and drug responses.MethodsDifferent regimens of L‐dopa monotreatment and L‐dopa‐ropinirole cotreatment were compared using measures of hypokinesia and dyskinesia. Striatal expression of ∆FosB and angiogenesis markers were studied immunohistochemically. Antidyskinetic effects of different drug categories were investigated in parallel groups of rats receiving either L‐dopa monotreatment or L‐dopa combined with ropinirole.ResultsWe defined chronic regimens of L‐dopa monotreatment and L‐dopa‐ropinirole cotreatment inducing overall similar abnormal involuntary movement scores. Compared with the monotreatment group, animals receiving the L‐dopa‐ropinirole combination exhibited an overall lower striatal expression of ∆FosB with a distinctive compartmental distribution. The expression of angiogenesis markers and blood–brain barrier hyperpermeability was markedly reduced after L‐dopa‐ropinirole cotreatment compared with L‐dopa monotreatment. Moreover, significant group differences were detected upon examining the response to candidate antidyskinetic drugs. In particular, compounds modulating D1 receptor signaling had a stronger effect in the L‐dopa‐only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L‐dopa‐ropinirole cotreated animals.ConclusionsCotreatment with ropinirole altered LID‐related neuroplasticity and pharmacological response profiles. The impact of adjuvant dopamine agonist treatment should be taken into consideration when investigating LID mechanisms and candidate interventions in both clinical and experimental settings. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Harmonizing bifactor models of psychopathology between distinct assessment instruments: Reliability, measurement invariance, and authenticity
Authors: Hoffmann Maurício Scopel , Moore Tyler Maxwell , Axelrud Luiza Kvitko , Tottenham Nim , Rohde Luis Augusto , Milham Michael Peter , Satterthwaite Theodore Daniel , Salum Giovanni Abrahão 
Published: January 2023

AbstractObjectivesModel configuration is important for mental health data harmonization. We provide a method to investigate the performance of different bifactor model configurations to harmonize different instruments.MethodsWe used data from six samples from the Reproducible Brain Charts initiative (N = 8,606, ages 5–22 years, 41.0% females). We harmonized items from two psychopathology instruments, Child Behavior Checklist (CBCL) and GOASSESS, based on semantic content. We estimated bifactor models using confirmatory factor analysis, and calculated their model fit, factor reliability, between‐instrument invariance, and authenticity (i.e., the correlation and factor score difference between the harmonized and original models).ResultsFive out of 12 model configurations presented acceptable fit and were instrument‐invariant. Correlations between the harmonized factor scores and the original full‐item models were high for the p‐factor (>0.89) and small to moderate (0.12–0.81) for the specific factors. 6.3%–50.9% of participants presented factor score differences between harmonized and original models higher than 0.5 z‐score.ConclusionsThe CBCL‐GOASSESS harmonization indicates that few models provide reliable specific factors and are instrument‐invariant. Moreover, authenticity was high for the p‐factor and moderate for specific factors. Future studies can use this framework to examine the impact of harmonizing instruments in psychiatric research.
A case of musical hallucinations induced by tramadol
Authors: Hase Tatsu , Yasui‐Furukori Norio , Yamaguchi Shigeki , Shimoda Kazutaka 
Published: January 2023

AbstractAimAlthough tramadol has been suggested to have a higher risk of producing hallucinations than other opioids, reports of musical hallucinations are extremely rare.Case PresentationA 72‐year‐old woman came to our department complaining of auditory hallucinations. She had been diagnosed with lumbar spinal canal stenosis associated with herniated and slipped disks. Due to persistent back pain, tramadol was started, and the dose was increased to 300 mg/day. The next day, she began to hear nursery rhymes, songs of the Ministry of Education, and folk songs. The musical auditory hallucinations disappeared with the use of antipsychotics and the discontinuation of tramadol. No relapse of musical auditory hallucinations was observed after the discontinuation of antipsychotics.ConclusionBased on the clinical course, we concluded that the auditory hallucinations were musical hallucinations induced by tramadol.
A processing fluency perspective on overhead aversion: How much is too much?
Authors: Allred Anthony T. , Amos Clinton 
Published: January 2023

AbstractOverhead aversion has afflicted the nonprofit sector in recent decades. Yet, questions remain regarding how high is too high from a donor perspective and at what level overhead expenses just “feel right.” Using processing fluency as a theoretical foundation, the central purpose of this research was to investigate whether a nonprofit overhead ratio fluency level exists that significantly reduces both donation likelihood and nonprofit perceptions. Results from two studies show that a 25% overhead ratio appears to be the proximate ceiling regarding what fluently fits within a potential donor's schema for acceptance. Overhead ratios exceeding this threshold tended to decrease donation likelihood and nonprofit perceptions in a relatively stable manner. Moreover, the 25% threshold seems most relevant to human and animal causes and not as relevant to arts and cultural nonprofits such as museums. The results suggest that donors have a preconceived overhead ratio limit. Nonprofits that exceed that threshold are in danger of deterring donors. If nonprofit overhead ratios exceed the donor fluency threshold, nonprofit managers should consider distinct promotional strategies that entice donors and diminish overhead aversion effects.
Photovoltaic integration in curved parts: Mechanical limits and key parameters from a theoretical point of view
Authors: Charpentier Jean‐Baptiste , Duigou Tatiana , Chambion Bertrand , Voarino Philippe , Chabuel Fabien 
Published: January 2023

AbstractPhotovoltaic cells are produced as thin flat layers. They behave as a brittle and elastic material that fails at a given level of stress. Conforming cells into curved geometries will a priori induce both flexure and membrane stresses. In the present work, an analytical model is derived to predict both stress distributions and intensities in a mono‐crystalline pseudo‐square cell. Furthermore, a second model is derived to find the main stresses within fractions of cells. For conventional cell dimensions, solutions predict a transition from flexure to membrane dominated stresses for most conformations as curvature increases. As a consequence, near failure stresses are mainly determined by cells size and aspect ratio. In contrast, flexion is the main contribution in a small subset of the curvature space or for small curvatures. In the corresponding cases, stresses scale in proportion to cells thickness. As a consequence, cell size and/or shape is the main parameter to reduce internal stresses in most cases. In particular, the use of fractions of cells can substantially decrease membrane stresses and thus increase the maximum curvature. For instance, in a case study with M0 cells and curvature radii of a few meters, the highest predicted tensile stress is 45
. In such a case, the larger M12 format gives a prediction of
. In contrast, thirds of cells give predictions of 25 and
, respectively.