bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Authors: Ai Zongyong , Niu Baohua , Yin Yu , Xiang Lifeng , Shi Gaohui , Duan Kui , Wang Sile , Hu Yingjie , Zhang Chi , Zhang Chengting , Rong Lujuan , Kong Ruize , Chen Tingwei , Guo Yixin , Liu Wanlu , Li Nan , Zhao Shumei , Zhu Xiaoqing , Mai Xuancheng , Li Yonggang , Wu Ze , Zheng Yi , Fu Jianping , Ji Weizhi , Li Tianqing 
Published: June 2023

AbstractStudies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage developments as well as underlying mechanisms remain obscure. Using 3D-cultured human embryos, herein we report a complete cell atlas of the early post-implantation lineages and decipher cellular composition and gene signatures of the epiblast and hypoblast derivatives. In addition, we develop an embryo-like assembloid (E-assembloid) by assembling naive hESCs and extraembryonic cells. Using human embryos and E-assembloids, we reveal that WNT, BMP and Nodal signaling synergistically, but functionally differently, orchestrate human peri-implantation lineage development. Specially, we dissect mechanisms underlying extraembryonic mesoderm and extraembryonic endoderm specifications. Finally, an improved E-assembloid is developed to recapitulate the epiblast and hypoblast developments and tissue architectures in the pre-gastrulation human embryo. Our findings provide insights of the human peri-implantation development, and the E-assembloid offers a useful model to disentangle cellular behaviors and signaling interactions that drive human embryogenesis.
Palmitoylation of the Hemagglutinin of Influenza B virus by ER-localized DHHC enzymes 1, 2, 4 and 6 is essential for virus replication
Authors: Meng Xiaorong , Veit Michael 
Published: June 2023

AbstractCovalent attachment of the fatty acids palmitate or stearate to the cytoplasmic domain of viral glycoproteins is often crucial for viral replication. This has previously been studied for the hemagglutinin (HA) of Influenza A virus and the responsible enzymes have been identified, but similar studies have not been performed with HA of Influenza B virus, which contains palmitate linked to two cysteines. We show here that the modification is essential for virus replication since exchange of both cysteines or the cysteine located at the end of the cytoplasmic tail prevented the generation of viable viruses. Viruses with an exchange of the membrane-distal cysteine rapidly reverted back to wild-type virus. Blocking exit of proteins from the endoplasmic reticulum (ER) revealed that palmitoylation of HA of Influenza B virus occurs in the ER, whereas acylation of HA of Influenza A virus also in the Golgi. Infecting cells deficient in DHHC palmitoyltransferases revealed that HA of Influenza B virus is acylated by the ER-localized DHHCs 1, 2, 4 and 6, which are thus different from the enzymes previously identified for acylation of HA of Influenza A virus. A comparison of predicted and experimentally determined protein structures suggests that the exclusive acylation of the HA of Influenza B virus with palmitate is not a function of the responsible DHHCs and that the transmembrane region may be critical for the acylation of HA of Influenza A and B virus by different DHHCs.ImportanceInfluenza viruses are a public health concern since they cause seasonal outbreaks and occasionally pandemics. Our study investigates the importance of a protein modification called "palmitoylation" in the replication of Influenza B virus. Palmitoylation involves attaching fatty acids to the viral protein hemagglutinin, and has previously been studied for Influenza A virus. We found that this modification is essential for the Influenza B virus to replicate, as mutating the sites where palmitate is attached prevented the virus from generating viable particles. Our experiments also showed that this modification occurs in the endoplasmic reticulum. We identified the specific enzymes responsible for this modification, which are different from those involved in palmitoylation of HA of Influenza A virus. Overall, our research illuminates the similarities and differences in fatty acid attachment to HA of Influenza A and B virus and identifies the responsible enzymes, which might be promising targets for antiviral therapy.
Job embeddedness and life satisfaction during pandemic: the impacts of work-from-home stressors and emotional exhaustion
Authors: Dechawatanapaisal Decha 
Published: June 2023

PurposeThis study applies the job demands-resources model the conservation of resources theory to explain and examine the impacts of home-work conflict, perceived insufficient organizational support, and perceived social isolation, that is, work-from-home stressors, oDesign/methodology/approachData were collected from 418 Thai employees who worked from home during the nationwide lockdowns at two time points. The hypotheses were tested and analyzed by means of a confirmatory factor analysis, structural equation modeling, and a bootstrapping procedure.FindingsThe results indicate that the three work-from-home stressors significantly cause emotional exhaustion and that these stressors are negatively associated with job embeddedness and life satisfaction via the mediation of emotional exhaustion.Research limitations/implicationsTo reduce error in parameter estimation due to self-report data, future research could use a more rigorous longitudinal design with a longer time lag and collect data from multiple sources.Practical implicationsRealizing how critical situations shape the workplace would help organizations understand the issues concerning a remote work approach and create more applicable interventions to improve employees' retention and wellbeing.Originality/valueThis study reinforces the application of COR in times of crisis and extends the traditional JD-R model beyond the normal work context.
Development and validation of natural user interfaces for semantic enrichment of BIM models using open formats
Authors: Matoseiro Dinis Fábio , Rodrigues Raquel , Pedro da Silva Poças Martins João 
Published: June 2023

Purpose
Despite the technological paradigm shift presented to the architecture, engineering, construction and operations sector (AECO), the full-fledged acceptance of the building information modelling (BIM) methodology has been slower than initially anticipated. Indeed, this study aims to acknowledge the need for increasing supportive technologies enabling the use of BIM, attending to available human resources, their requirements and their tasks.

Design/methodology/approach
A complete case study is described, including the development process centred on design science research methodology followed by the usability assessment procedure validated by construction projects facility management operational staff.

Findings
Results show that participants could interact with BIM using openBIM processes and file formats naturally, as most participants reached an efficiency level close to that expected for users already familiar with the interface (i.e. high-efficiency values). These results are consistent with the reported perceived satisfaction and analysis of participants’ discourses through 62 semi-structured interviews.

Originality/value
The contributions of the present study are twofold: a proposal for a virtual reality openBIM framework is presented, particularly for the semantic enrichment of BIM models, and a methodology for evaluating the usability of this type of system in the AECO sector.
The direct and indirect effects of financial socialization and psychological characteristics on young professionals' personal financial management behavior
Authors: Goyal Kirti , Kumar Satish , Hoffmann Arvid 
Published: June 2023

PurposePrior work expresses concern about young people's rising debt and lack of financial preparedness. This study focuses on how financial socialization and psychological characteristics affect the personal financial management behavior (PFMB) of young professionals in India. The authors examine both the direct effect of these factors and the indirect effects through financial literacy and aforementioned psychological characteristics as mediators.Design/methodology/approachThe authors develop a conceptual framework based on the extant literature and empirically test its hypotheses employing partial least squares structural equation modelling (PLS-SEM).FindingsAttitude towards money, financial self-efficacy, financial risk tolerance, financial socialization through parental direct teaching and peers, and media are all positively associated with young professionals' PFMB, whereas external locus of control and procrastination are negatively associated with their PFMB. Almost all psychological characteristics partially mediate the association between financial socialization and PFMB. Finally, financial literacy plays a partially mediating role in the association between procrastination and PFMB as well as between financial socialization and PFMB.Practical implicationsThis study helps regulators and policymakers understand PFMB among young professionals. Interventions should build on the positive role of financial socialization, cultivating a good attitude towards money and financial self-efficacy, and reducing reliance on an external locus of control and procrastination. This study also helps policymakers and financial educators develop societally beneficial personal finance programs.Originality/valueThis research investigates social, psychological and cognitive characteristics in a comprehensive framework to further the authors’ understanding of the topic of PFMB.
The effects of digital transformation on supply chain resilience: a moderated and mediated model
Authors: Yuan Yaqin , Tan Hongying , Liu Linlin 
Published: June 2023

PurposeThis study aims to investigate the impact of digital transformation on supply chain resilience. Additionally, the paper examines the mediating effect of supply chain process integration as well as the moderating effect of environmental uncertainty in the relationship between digital transformation and supply chain resilience.Design/methodology/approachDrawing on digital empowerment theory, this study proposes a theoretical model. Using survey data collected from 216 enterprises in China, the study employs structural equation modeling to validate the theoretical model.FindingsThe results reveal that digital transformation has a significant impact on supply chain resilience. Three dimensions of supply chain process integration, namely, information flow integration, physical flow integration, and financial flow integration mediate the relationship between digital transformation and supply chain resilience. In addition, environmental uncertainty including market uncertainty and technology uncertainty positively moderates the relationship between digital transformation and supply chain resilience.Originality/valueFirst, this paper provides empirical evidence on both the direct and indirect effects of digital transformation on supply chain resilience. Second, this paper enriches the understanding of how supply chain integration impacts supply chain resilience in the digital transformation era by adopting a more granular perspective of process integration rather than broad external and internal integrations. Furthermore, this paper extends the knowledge of the role of external environment in digital transformation and supply chain risk management by examining the moderating effects of market uncertainty and technology uncertainty.
User experience of digital science and education evaluation platform: identification and analysis of key influencing factors
Authors: Qiu Junping , Xu Zhongyang , Luo Haibei , Zhou Jianing , Zhang Yu 
Published: June 2023

PurposeEstablishing and developing digital science and education evaluation platforms (DSEEPs) have several practical implications for the development of China's science, technology and education. Identifying and analyzing the key factors influencing DSEEP user experience (UX) can improve the users' willingness to use the platform and effectively promote its sustainable development.Design/methodology/approachFirst, a literature survey, a five-element model of UX and semi-structured interviews were used in this study to develop a DSEEP UX-influencing factor model, which included five dimensions and 22 influencing factors. Second, the model validity was verified using questionnaire data. Finally, the key influencing factors were identified and analyzed using a fuzzy decision-making trial and evaluation laboratory (fuzzy-DEMATEL) method.FindingsFourteen influencing factors, including diverse information forms and comprehensive information content, are crucial for the DSEEP UX. Its optimization path is “‘Function Services’ → ‘Information Resources’ → ‘Interaction Design’ → ‘Interface Design’ and ‘Visual Design’.” In this regard, platform managers can take the following measures to optimize UX: strengthening functional services, improving information resources, enhancing the interactive experience and considering interface effects.Originality/valueThis study uses a combination of qualitative and quantitative research methods to determine the key influencing factors and optimization path of DSEEP UX. Optimization suggestions for UX are proposed from the perspective of platform managers, who provide an effective theoretical reference for innovating and developing a DSEEP.
The role of brand self-congruence, brand love and brand attachment on brand advocacy: a serial mediation model
Authors: Shimul Anwar Sadat , Phau Ian 
Published: June 2023

PurposeThis paper aims to examine the impact of brand self-congruence on brand advocacy. In addition, the roles of brand love and attachment are examined through a serial mediation model.Design/methodology/approachA total of 324 valid and useable responses collected from an Australian consumer panel were analysed through IBM SPSS. Underpinned by social identity theory and self-expansion theory, a set of hypotheses was examined in a research model.FindingsThe findings show that consumers' brand self-congruence positively impacts brand love, attachment and advocacy intention. Moreover, brand attachment and love mediate the relationship between brand self-congruence and advocacy.Practical implicationsThe findings of this research suggest that brand managers should cultivate emotions to build a strong consumer–brand relationship.Originality/valueThis research advances the current understanding of brand advocacy literature concerning brand self-congruence, love and attachment. The findings suggest that consumers' brand self-congruence, combined with brand love and attachment, will generate greater advocacy.
Inside out and upside down? Perceptions of temporary employment histories in the time of COVID
Authors: Song Fei , Lamb Danielle 
Published: June 2023

PurposePerceptions of employment histories are important insofar as they influence future job prospects. Critically, in light of the current pandemic, wherein many individuals are likely to have unanticipated employment gaps and/or temporary work experiences, this exploratory study aims to seek a better understanding of the signal associated with temporary employment histories, which is particularly germane to individuals' employment trajectories and a successful labour market recovery.Design/methodology/approachDrawing primarily on signalling theory and using a simulated hiring decision experiment, the authors examined the perceptions of temporary employment histories, as well as the period effect of COVID-19, a major exogenous event, on the attitudes of fictitious jobseekers with standard, temporary and unemployment histories.FindingsThe authors find that prior to COVID-19 unemployed and temporary-work candidates were perceived less favourably as compared to applicants employed in a permanent job. During the COVID-19 pandemic, assessments of jobseekers with temporary employment histories were less critical and the previously negative signal associated with job-hopping reversed. This study’s third wave of data, which were collected post-COVID, showed that such perceptions largely dissipated, with the exception for those with a history of temporary work with different employers.Practical implicationsThe paper serves as a reminder to check, insofar as possible, preconceived biases of temporary employment histories to avoid potential attribution errors and miss otherwise capable candidates.Originality/valueThis paper makes a unique and timely contribution by focussing and examining the differential effect of economic climate, pivoted by the COVID-19 pandemic, on perceptions of temporary employment histories.
Can sustainability performance mitigate the negative effect of policy uncertainty on the firm valuation?
Authors: Azimli Asil , Cek Kemal 
Published: June 2023

Purpose
The purpose of this paper is to test if building reputation capital through environmental, social and governance (ESG) investing can mitigate the negative effect of economic policy uncertainty (EPU) on firms’ valuation.

Design/methodology/approach
This study uses an unbalanced panel of 591 financial firms between 2005 and 2021 from Canada, France, Germany, Italy, Japan, the United Kingdom (UK) and the USA. Ordinary least square method is used in the empirical tests. To alleviate a potential endogeneity problem, robustness tests are performed using the two-stage least square approach with instrumental variables.

Findings
The results of this paper show that sustainable reporting can offset the negative effect of EPU on the valuation of financial firms. Consistent with the stakeholder-based reputation-building hypothesis, sustainability performance may have an insurance-like impact on firms’ valuation during periods of high uncertainty.

Practical implications
According to the findings, during high policy uncertainty periods, investors accept to pay a premium for the stocks of the firms which built social capital through environmental and social investments. Accordingly, it is suggested that regulatory bodies and governments motivate firms to increase their stakeholder orientation to attain higher reputation capital.

Social implications
Managers can mitigate the negative impact of policy uncertainty on the value of their firms via building social capital, which will increase financial market stability in return, and portfolio investors may use such firms for portfolio optimization decisions.

Originality/value
To the best of the authors’ knowledge, this paper is one of the first to examine the mitigating role of ESG investing on EPU and firm valuation relationships for financial firms. Thus, this study provides new insights related to the impact of ESG performance on valuation during uncertain times.
Tourist involvement in vacation planning and booking: impact on word of mouth and loyalty
Authors: Andersen Cecilie , Engeset Marit Gundersen , Nyhus Ellen Katrine 
Published: June 2023

Purpose
This paper aims to explore how different levels of involvement in the prevacation phase affect vacationers’ subsequent satisfaction, word of mouth (WOM) recommendations and loyal behavior with regard to the planning/booking process.

Design/methodology/approach
Data from a field study (N = 5,158) in a travel planning context are used to investigate the differences in WOM recommendations and loyalty between self-packagers (higher involvement) and package buyers (lower involvement).

Findings
Tourists who are less involved in the prevacation phase are more likely to recommend the planning/booking process, while more involved tourists are more likely to repeat the same planning/booking process than package buyers.

Practical implications
The findings have implications for tourist agencies, tour operators, tourism suppliers and tourism marketers in terms of customer retention and WOM communication. These findings also have theoretical implications for the WOM and loyalty literature.

Originality/value
This paper reveals how involvement in travel planning may affect satisfaction, WOM recommendation and loyalty behavior. These relationships have not been investigated before.
On pathological orthorhombic models
Authors: Stovas Alexey , Roganov Yuriy , Roganov Vyacheslav 
Published: June 2023

AbstractThe singularity directions are very important for wave propagation in anisotropic media since they result in complications of the wavefront, amplitudes and polarization fields. Usually, the singularities are associated with shear waves. However, there is a class of anisotropic models with orthorhombic symmetry, which results in both S1S2 and PS1 types of singularities with abnormal polarization. In this case, we can have the singularity points and singularity lines of different types. Thus, we classify and analyse these models in the phase domain. The group velocity images of both singularity points and lines are also defined.
Changes in alcohol consumption reported on routine healthcare screenings are associated with changes in depression symptoms
Authors: Hallgren Kevin A. , Jack Helen E. , Oliver Malia , Berger Douglas , Bobb Jennifer F. , Kivlahan Daniel R. , Bradley Katharine A. 
Published: June 2023

AbstractBackgroundThe Alcohol Use Disorders Identification Test‐Consumption version (AUDIT‐C) has been robustly validated as a point‐in‐time screen for unhealthy alcohol use, but less is known about the significance of changes in AUDIT‐C scores from routine screenings over time. Unhealthy alcohol use and depression commonly co‐occur, and changes in drinking often co‐occur with changes in depression symptoms. We assess the associations between changes in AUDIT‐C scores and changes in depression symptoms reported on brief screens completed in routine care.MethodsThe study sample included 198,335 primary care patients who completed two AUDIT‐C screens 11 to 24 months apart and the Patient Health Questionnaire‐2 (PHQ‐2) depression screen on the same day as each AUDIT‐C. Both screening measures were completed as part of routine care within a large health system in Washington state. AUDIT‐C scores were categorized to reflect five drinking levels at both time points, resulting in 25 subgroups with different change patterns. For each of the 25 subgroups, within‐group changes in the prevalence of positive PHQ‐2 depression screens were characterized using risk ratios (RRs) and McNemar's tests.ResultsPatient subgroups with increases in AUDIT‐C risk categories generally experienced increases in the prevalence of positive depression screens (RRs ranging from 0.95 to 2.00). Patient subgroups with decreases in AUDIT‐C risk categories generally experienced decreases in the prevalence of positive depression screens (RRs ranging from 0.52 to 1.01). Patient subgroups that did not have changes in AUDIT‐C risk categories experienced little or no change in the prevalence of positive depression screens (RRs ranging from 0.98 to 1.15).ConclusionsAs hypothesized, changes in alcohol consumption reported on AUDIT‐C screens completed in routine care were associated with changes in depression screening results. Results support the validity and clinical utility of monitoring changes in AUDIT‐C scores over time as a meaningful measure of changes in drinking.