bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with secretory IgA levels in colostrum and breastmilk
Authors: Mulyani Sri Priyantini , Winarto Suprihati , Karyadini Hesti Wahyuningsih 
Published: March 2023

Background Secretory IgA (sIgA) content of breastmilk in the first postpartum month is a reflection of the pregnant woman's immune response to environmental antigen exposure. The role of secretory IgA in breastmilk is to protect and support the development of the neonatal immune response in early life.
Objective To examine possible factors associated with sIgA levels in breastmilk and colostrum, including environmental exposure, food consumed, maternal history of atopy, and the appearance of allergic symptoms in infants. As a secondary objective, we determined the association between infant factors (IgE, exposure to cigarette smoke) and maternal factors (sIgA, maternal allergies) with infant allergies.
Methods This prospective cohort study of 80 postpartum mothers and their infants was conducted at Sultan Agung Islamic Hospital, Semarang. We collected maternal colostrum on the second or third postpartum day and mature milk between the 22nd to 25th postpartum day. Exposure factors to mothers and infants in the final trimester of pregnancy up to one month postpartum was recorded through a questionnaire and home visits. The infant’s IgE level was measured at 4 months of age.
Results Mean colostrum sIgA was 108.9 (SD 16.5) mg/dL (95%CI 97.9 to 121.1 mg/dL) and mean mature milk sIgA was 94.1 (SD 23.9) mg/dL (95%CI 89.1 to 99.2 mg/dL). Mean colostrum sIgA levels were higher in mothers exposed to cigarette smoke [119.1 (SD 1.7) vs. 92.9 (SD 1.5) mg/dL; P=0.026] and frequent infections [128.2 (SD 1.7) vs. 95.9 (SD 1.6) mg/dL; P=0.007] compared to that in unexposed mothers. Mean colostrum sIgA was also higher in mothers with atopic allergy than in those without (136.8 mg/dL vs. 99.3 mg/dL; p=0.017) and in mothers of infants with IgE levels >29 IU/ml than in mothers of infants with IgE levels <29 IU/mL (136.8 vs. 101.2 mg/mg/dL; P=0.045). Elevated colostrum sIgA (>136.8 mg/dL) was not associated with allergies in the infants (P=0.269).
Conclusions Maternal atopic allergy and frequent infections are associated with increased colostrum sIgA levels. Breastmilk sIgA levels are not associated with allergies in the infant. Maternal exposure to antigens may stimulate the production of specific breastmilk sIgA.
Blood pressure to height ratio for screening hypertension among Indonesian adolescents
Authors: Trihono Partini Pudjiastuti , Sihombing Jeanne Laurensie , Dewi Rismala 
Published: March 2023

Background Pediatric hypertension is an emerging health issue due to its increasing prevalence. Age-, gender-, and height-specific blood pressure percentiles have been widely used as a primary tool for detection of hypertension in the pediatric population. However, this method is too complicated to be used in general pediatric practice. The blood pressure to height ratio has been proposed as a practical tool to detect hypertension in children.
Objective To evaluate the accuracy of blood pressure to height ratio to be used as a tool for screening high blood pressure in Indonesian adolescents.
Methods This diagnostic test study using data from the 2013 Indonesia Basic Health Research (Riset Kesehatan Dasar/RISKESDAS) report included 39,057 adolescents aged 15-18 years with complete data on age, gender, weight, height, and blood pressure. Blood pressure values were classified using the 2017 American Academy of Pediatrics (AAP) hypertension clinical guidelines. Blood pressure to height ratio was calculated as mmHg/cm body height. A receiver-operator characteristics (ROC) curve analysis was performed to assess the accuracy of systolic blood pressure to height ratio (SBPHR) and diastolic blood pressure to height ratio (DBPHR) for screening high blood pressure in adolescents. The optimal cut-off points, sensitivity, and specificity of SBPHR and DBPHR were calculated.
Results The optimal cut-off points for defining elevated blood pressure in male adolescents aged 13-18 years were SBPHR 0.69 for male adolescents (sensitivity 96%, specificity 80%) and DBPHR 0.46 (sensitivity 97%, specificity 84%). In female adolescents, the optimal cut-offs were SBPHR 0.72 (sensitivity 97%, specificity 82%) and DBPHR 0.48 (sensitivity 98% and specificity 79%).
Conclusion Blood pressure to height ratio is a practical method with high sensitivity and specificity for detecting elevated blood pressure in Indonesian adolescents aged 15 to 18 years.
Simplified MIMO design of observer-based PI control in view of input saturation
Authors: Hippe Peter 
Published: March 2023

Abstract
In observer-based control integral or controller windup can systematically be prevented by the observer technique, i.e., by feeding the saturated plant input signal into the observer. This prevents all windup effects caused by the dynamics of the compensator. The possibly remaining windup effects are then the same as if constant state feedback control had been applied. When using the classic approach for robust rejection of persistent disturbances the state-plus-disturbance observer is subdivided into the state observer and the controlled signal model. Thus the observer technique is only applicable when taking additional measures or when resorting to a recently published dual design method. Here, a very simple design for MIMO PI compensators is suggested which directly yields the basis for the observer technique.
Identifikation auslösender Umstände von SOTIF-Gefährdungen durch systemtheoretische Prozessanalyse
Authors: Graubohm Robert , Loba Marvin , Nolte Marcus , Maurer Markus 
Published: March 2023

Zusammenfassung
Um bereits in der Konzeptphase autonomer Fahrzeuge einen fundierten Eindruck bestehender Risikopotenziale zu erhalten, werden im Zuge von deduktiven und induktiven SOTIF-Analysen mögliche auslösende Umstände für gefährliches Verhalten untersucht. In diesem Zusammenhang wird in der ISO 21448 die Durchführung einer systemtheoretischen Prozessanalyse (STPA) vorgeschlagen. In diesem Beitrag führen wir deutsche Terminologie für SOTIF-Betrachtungen ein und setzen uns im Zuge einer Anwendung kritisch mit der STPA-Theorie auseinander, wobei wir begleitend methodische Ergänzungen anregen.
Prediction based activation of vehicle safety systems – a contribution to improve to occupant safety by validation of pre-crash information and crash severity plus restraint strategy prediction
Authors: Alphonso Sequeira Gerald Joy 
Published: March 2023

Abstract
This work presents an approach to activate vehicle safety systems based on a pre-crash prediction. It focuses on the three major topics namely, crash validation, the geometry-estimation, and the crash severity and restraint strategy prediction. The topic of crash validation is administered by a proposal of a novel contact-based validation sensor along with the experimental investigations for comparison with other sensors.
Die Bibliothek im Jahr 2040
Authors: Kohle Hubertus 
Published: March 2023

Zusammenfassung
Im Zeichen der Digitalisierung verlieren die Bibliotheken ihre vorrangige Funktion, Aufbewahrungsorte von Büchern zu sein. Schon jetzt entwickeln sie sich mehr und mehr zu sozialen Räumen, in denen menschliche Interaktion neben die einsame Lektüre tritt. Die Digitalisierung zielt auf Stärkung der Interaktivität im Umgang mit allen Artefakten ab, so auch Büchern. Sie lädt ein zu Kommentierung, Bearbeitung, Veränderung. Vermutet wird hier, dass die Bibliothek zukünftig verstärkt als Raum fungieren wird, in dem diese Prozesse stattfinden. Das führt zu einer durchgreifenden Neukonzeption, die im Übrigen alle Bildungsinstitutionen betreffen dürfte.
Desiccation and thermo-tolerance of Fucus guiryi (Phaeophyceae) from its southernmost populations (Canary Islands, Eastern Atlantic)
Authors: Ruiz-Medina Marcos Adrián , Fernández-Marín Beatriz , Sansón Marta , Sangil Carlos , González-Rodríguez Águeda María 
Published: March 2023

Abstract
Populations inhabiting the periphery of a species’ distribution suffer the immediate pressure of the environmental changes. Studying their physiology under stressful conditions is essential in the context of climate change. We characterized two morphotypes with measurements of length, thickness and width of the thallus of the macroalga Fucus guiryi in two localities (north and south) in Tenerife (Canary Islands), the southern limit of distribution of the species. We hypothesized that the individuals from the north locality, especially the large morphotype, would be more vulnerable to desiccation and high temperatures than those from the south. Tolerance to desiccation was tested through two long desiccation experiments and by comparing the vegetative and reproductive blades. Tolerance to high temperatures was tested by keeping the individuals in seawater (26–32 °C) for 24 h. The recovery of physiological functions after the stressful conditions was estimated through maximal photochemical efficiency of PSII. Results indicate that both of the two morphometrically differentiated morphotypes were tolerant to prolonged desiccation; however, the small one was more affected, particularly in the northern locality. The reproductive blades were hardly affected, indicating greater tolerance to desiccation than the vegetative blades. Fucus guiryi showed tolerance to high temperatures (32 °C) suggesting plasticity to future warming scenarios.
Effect of matrix composition on properties of polyamide 66/polyamide 6I-6T composites with high content of continuous glass fiber for optimizing surface performance
Authors: Xie Jiaxiang 
Published: March 2023

Abstract
To optimize the surface performance of the composites of polyamide 66 and continuous glass fiber (50/50, weight ratio), poly(hexamethylene isoftalamide-co-terephthalamide) (PA6I-6T) was introduced. The composites were prepared by a twin-screw extruder, and the effect of PA6I-6T on the thermal and mechanical properties, as well as surface appearance was investigated. The results showed that the crystallization temperature and the melting point of the composites decreased with increasing the amount of PA6I-6T. The Jeziorny method proved that the presence of PA6I-6T did not change the nucleation mode and the crystal growth of PA66 in the hybrid matrix, and the Mo method revealed that the crystallization rate of PA66 decreased first and then increased with the increase of the PA6I-6T content. The reduction in the “floating fiber” on the surface of the composites was attributed to the decrease of the crystallization rate of PA66 in the presence of PA6I-6T. It was shown that the composites with smooth surface had a large melt flow index. Moreover, the composites with high content of PA6I-6T had low heat deformation temperatures. The mechanical properties of the composites did not change significantly with the increase of the PA6I-6T content. Scanning electron microscope (SEM) images revealed that glass fiber was evenly distributed in the matrix and strongly oriented parallel to the injection direction.
Study on the accidents analyses of a single channel for XADS by using MPC-LBE code
Authors: Zhang Ling , Song Tianxin , Gu Zhixing , Dai Jianing , Ou Wenlan , Pan Qiwen , Gong Zhengyu 
Published: March 2023

Abstract
Accelerator Driven sub-critical System (ADS), which employs the high-energy proton beam generated by accelerator to bombard the target nucleus and generate spallation neutrons as external neutrons to drive and maintain the operation of its sub-critical reactor, is of great significance in nuclear waste treatment and disposal. As the instability of proton beam would affect the power level of the reactor and threaten the safety of ADS, Beam Trip (BT) and Beam OverPower (BOP) are commonly considered to be its two typical transient accidents. As for the sub-critical reactor, the Transient OverPower (TOP) is also one of typical transient accidents that should be considered, which is mainly caused by reactivity insertion under certain cases, such as SGTR (Steam Generator Tube Rupture) accident. For the subcritical reactors, the transient evolution behaviors are strongly affected by the subcriticality value. On the one hand, the subcriticality values of ADS design should take safety margin and power gain into consideration. On the other hand, the subcriticality value is variable with the burnup of reactors. So it is necessary to study the safety characteristics of the subcritical reactors under different subcriticality values, in this paper, the transient safety characteristics of a single channel for XADS under BT, BOP and TOP accidents of different subcriticality values were investigated by using MPC-LBE code.
Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3
Authors: Yang Chenyu , Yamaki Shanni , Jung Tyler , Kim Brian , Huyhn Ryan , McKemy David D. 
Published: March 2023

The detection of environmental temperatures is critical for survival, yet inappropriate responses to thermal stimuli can have a negative impact on overall health. The physiological effect of cold is distinct among somatosensory modalities in that it is soothing and analgesic, but also agonizing in the context of tissue damage. Inflammatory mediators produced during injury activate nociceptors to release neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P, inducing neurogenic inflammation, which further exasperates pain. Many inflammatory mediators induce sensitization to heat and mechanical stimuli but, conversely, inhibit cold responsiveness, and the identity of molecules inducing cold pain peripherally is enigmatic, as are the cellular and molecular mechanisms altering cold sensitivity. Here, we asked whether inflammatory mediators that induce neurogenic inflammation via the nociceptive ion channels TRPV1 (vanilloid subfamily of transient receptor potential channel) and TRPA1 (transient receptor potential ankyrin 1) lead to cold pain in mice. Specifically, we tested cold sensitivity in mice after intraplantar injection of lysophosphatidic acid or 4-hydroxy-2-nonenal, finding that each induces cold pain that is dependent on the cold-gated channel transient receptor potential melastatin 8 (TRPM8). Inhibition of CGRP, substance P, or toll-like receptor 4 (TLR4) signaling attenuates this phenotype, and each neuropeptide produces TRPM8-dependent cold pain directly. Further, the inhibition of CGRP or TLR4 signaling alleviates cold allodynia differentially by sex. Last, cold pain induced by both inflammatory mediators and neuropeptides requires TRPM8, as well as the neurotrophin artemin and its receptor GDNF receptor α3 (GFRα3). These results are consistent with artemin-induced cold allodynia requiring TRPM8, demonstrating that neurogenic inflammation alters cold sensitivity via localized artemin release that induces cold pain via GFRα3 and TRPM8.SIGNIFICANCE STATEMENTThe cellular and molecular mechanisms that generate pain are complex with a diverse array of pain-producing molecules generated during injury that act to sensitize peripheral sensory neurons, thereby inducing pain. Here we identify a specific neuroinflammatory pathway involving the ion channel TRPM8 (transient receptor potential cation channel subfamily M member 8) and the neurotrophin receptor GFRα3 (GDNF receptor α3) that leads to cold pain, providing select targets for potential therapies for this pain modality.
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons
Authors: Zhang Ming , Yang Kehui , Wang Qi-Hui , Xie Ling , Liu Qiaoqiao , Wei Runa , Tao Yang , Zheng Hong-Li , Lin Ninghua , Xu Hengjun , Yang Li , Wang Hongjun , Zhang Tingruo , Xue Zhouya , Cao Jun-Li , Pan Zhiqiang 
Published: March 2023

RNA N4-acetylcytidine (ac4C) modification is increasingly recognized as an important layer of gene regulation; however, the involvement of ac4C in pain regulation has not been studied. Here, we report that N-acetyltransferase 10 protein (NAT10; the only known ac4C “writer”) contributes to the induction and development of neuropathic pain in an ac4C-dependent manner. Peripheral nerve injury increases the levels of NAT10 expression and overall ac4C in injured dorsal root ganglia (DRGs). This upregulation is triggered by the activation of upstream transcription factor 1 (USF1), a transcription factor that binds to theNat10promoter. Knock-down or genetic deletion of NAT10 in the DRG abolishes the gain of ac4C sites inSyt9mRNA and the augmentation of SYT9 protein, resulting in a marked antinociceptive effect in nerve-injured male mice. Conversely, mimicking NAT10 upregulation in the absence of injury evokes the elevation ofSyt9ac4C and SYT9 protein and induces the genesis of neuropathic-pain-like behaviors. These findings demonstrate that USF1-governed NAT10 regulates neuropathic pain by targetingSyt9ac4C in peripheral nociceptive sensory neurons. Our findings establish NAT10 as a critical endogenous initiator of nociceptive behavior and a promising new target for treating neuropathic pain.SIGNIFICANCE STATEMENTThe cytidine N4-acetylcytidine (ac4C), a new epigenetic RNA modification, is crucial for the translation and stability of mRNA, but its role for chronic pain remains unclear. Here, we demonstrate that N-acetyltransferase 10 (NAT10) acts as ac4C N-acetyltransferase and plays an important role in the development and maintenance of neuropathic pain. NAT10 was upregulated via the activation of the transcription factor upstream transcription factor 1 (USF1) in the injured dorsal root ganglion (DRG) after peripheral nerve injury. Since pharmacological or genetic deleting NAT10 in the DRG attenuated the nerve injury-induced nociceptive hypersensitivities partially through suppressingSyt9mRNA ac4C and stabilizing SYT9 protein level, NAT10 may serve as an effective and novel therapeutic target for neuropathic pain.
Nerve regeneration by interferon intervention in aging brain
Authors: Wang Fanwen , Pei Duanqing 
Published: March 2023

Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances (Kalamakis et al, 2019). Given that low‐level type‐I IFN under normal physiological conditions can promote dormant hematopoietic stem cell differentiation (Baldridge et al, 2010), whether there is an inner connection between IFN signaling and NSC function remains elusive. In this issue of EMBO Molecular Medicine, Carvajal Ibanez et al (2023) reveal that IFN‐β, a type‐I interferon, induces cell‐type‐specific interferon‐stimulated genes (ISGs) and regulates global protein synthesis by orchestrating mTOR1 activity and stem cell cycle that retain NSCs at the G0 phase and repress Sox2 expression. As a consequence, NSCs exit the activation state and become inclined to differentiation.
Improving Home Caregiver Independence With Central Line Care for Pediatric Cancer Patients
Authors: Wong Chris I. , Desrochers Marie D. , Conway Margaret , Stuver Sherri O. , Mahan Riley M. , Billett Amy L. 
Published: March 2023

OBJECTIVE
Home caregivers (eg parents) of pediatric patients with cancer with external central lines (CL) must carefully maintain this device to prevent complications. No guidelines exist to support caregiver skill development, assess CL competency, follow-up after initial CL teaching, and support progress over time. We aimed to achieve &gt;90% caregiver independence with CL care within 1 year through a family-centered quality improvement intervention.

METHODS
Drivers to achieve CL care independence were identified using surveys and interviews of patient or caregivers, a multidisciplinary team with patient or family representatives, and piloting clinic return demonstrations (teach-backs). A family-centered CL care skill-learning curriculum, with a postdischarge teach-back program, was implemented using plan-do-study-act cycles. Patients or caregivers participated until independent with CL flushing. Changes included: language iterations to maximize patient or caregiver engagement, developing standardized tools for home use and for teaching and evaluating caregiver proficiency on the basis of number of nurse prompts required during the teach-back, earlier inpatient training, and clinic redesign to incorporate teach-backs into routine visits. The proportion of eligible patients whose caregiver had achieved independence in CL flushing was the outcome measure. Teach-back program participation was a process measure. Statistical process control charts tracked change over time.

RESULTS
After 6 months of quality improvement intervention, &gt;90% of eligible patients had a caregiver achieve independence with CL care. This was sustained for 30 months postintervention. Eighty-eight percent of patients (n = 181) had a caregiver participate in the teach-back program.

CONCLUSION
A family-centered hands-on teach-back program can lead to caregiver independence in CL care.
Space-time patterns and drivers of migrant bird communities in coastal Piauí State, Brazil
Authors: Cardoso Cleiton O. , Sales Davi da S. , Nascimento Muryllo dos S. , Siqueira Airton Janes da S. , Pereira Ocivana A. , Dos Santos Suely S. , Dos Santos Francisco das Chagas V. , Carneiro Pedro B. de M. , Guzzi Anderson 
Published: March 2023

Introduction: Migration is a natural phenomenon that includes annual movements of many bird species in response to seasonal cycles. With approximately one third of all living bird species, South America has an important avifauna, and many migrants land in Brazil at stopping points and wintering sites. Objective: To identify associations between migrant birds and coastal vegetation, and environmental influence of on migration. Methods: At 10 points along the coast of Piauí State, Brazil, we made visual censuses and mist net captures, between April 2009 and February 2016. Results: We identified 82 migrant bird species (13 orders; 28 families) that represented 41 intracontinental migrating species, 26 northern visiting species, 14 nomad species and one vagrant species. The richness peaks were at the beginning and end of both dry and rainy seasons, matching insolation and atmospheric pressure. There were spatial pattern differences among vegetation complexes. Chrysolampis mosquitus is an indicator of caatinga vegetation, Numenius phaeopus of wetland, Charadrius collaris of non-flooding fields, Rostrhamus sociabilis of forest-grassland transition, and Columbina picui of orchards. Despite differences in number and species composition within vegetation types, the temporal pattern in species richness was similar among flooded fields, non-flooded fields, and transition grassland categories. Conclusions: Migrant birds occupy specific environments during their permanence along the coast of Piauí State, with richness matching insolation and atmospheric pressure.