bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS STRATEGI PEMASARAN VAPESTORE BRAND REFRE5H DI MALL KOTA KASABLANKA MELALUI PENDEKATAN SWOT
Authors: Hendra Saputra Dwi , Widodo Sugeng 
Published: January 2025

Vapestore Brand REFRE5H, located in Mall Kota Kasablanka, is one of the vape stores trying to compete in the increasingly competitive market by introducing new products and flavor variants. This research uses a qualitative method with a descriptive approach and SWOT analysis to determine effective marketing strategies for REFRE5H. Based on the research, it is concluded that the strategy based on the SWOT matrix, Strength-Opportunity (SO) Strategies, Building Relationships and Networks, maximizing the privilege as a large company in building relationships, and comprehensive marketing strategies to increase visibility and market penetration. Then Weakness-Opportunity (WO) Strategies, innovation and capacity improvement, focus on new flavor innovations and product capacity enhancement to address weaknesses and capitalize on existing market opportunities. Next, Strength-Threat (ST) Strategies, maintain distinctive features and affordable prices, preserve the uniqueness of REFRE5H products with Indonesian flavor variants while ensuring competitive prices to counter threats from competition and market trend changes. Therefore, Strengths-Weaknesses (SW) Strategies, REFRE5H needs to innovate new flavors and enhance product capacity so that it can be used longer by consumers. And Weakness-Threat (WT) Strategies, comprehensive promotion strategies formulate comprehensive promotion strategies to address threats from competition and market trend changes. Improve product promotion capabilities both online and offline to maintain market share. By leveraging strengths and opportunities while overcoming weaknesses and threats, REFRE5H can strengthen its position in the market and continue to grow successfully. This research not only fulfills the requirements of an academic assignment but also provides recommendations for business actors in the vape industry, particularly for the Vapestore Brand REFRE5H at Mall Kota Kasablanka
Comparison of Clomiphene Citrate and Letrozole in induction of ovulation among patients with PolyCystic Ovarian syndrome (PCOS) Primary Sub-fertility
Authors: Yasir Khan Urooj , Mehwish  , Nafees Sehrish , Raishem  , Mushtaq Sumera , Nafees Saba 
Published: January 2025

Objective: To compare the efficacy of clomiphene and Letrozole in the induction of ovulation in patients with primary ovarian sub-fertility.
Methodology: This was a Randomized control trial study carried out at Dow University Hospital Karachi, Ojha Campus, Karachi after approval of synopsis from February 2016 to January 2017. The required sample size was 164 (82 in the Letrozole group and 82 in the CC group). Non-probability consecutive sampling technique was used. Females of 18-40 years irrespective of weight, years of marriage, and duration of sub-fertility with primary ovarian sub-fertility were included in the study. SPSS was used for data analysis.
Results: Total of 164 women were enrolled in the study. 82 women were given Clomiphene Citrate and 82 were treated with Letrozole. The mean age was found to be 28.48±4.12 in the clomiphene citrate group whereas 28.45±3.01 in the Letrozole group. The results showed improved results among the group with Letrozole drug compared to Clomiphene Citrate. Efficacy was positively found with 1st cycle, 2nd cycle & 3rd cycle in 2 (2.4%), 23 (28.05%) & 32 (39.02%) respondents respectively with Clomiphene Citrate. Whereas efficacy was positive with 1st cycle, 2nd cycle & 3rd cycle in 18 (21.9%), 34 (41.4%) & 24 (29.2%) respondents respectively with Letrozole.
Conclusion: Letrozole appeared to be the effective drug of choice in ovulation induction among patients who failed to conceive, however, the clomiphene citrate was found to be most effective in women. The dosage of Letrozole is much lower mg with effective pregnancy results compared to Clomiphene Citrate clomiphene citrate.
Phytochemical Study and In vitro Antibacterial Activities of Extracts from Three Ivorian Medicinal Plants Traditionally Used to Treat Inflammatory Dermatoses in the Mé Area, South-East of Ivory Coast
Authors: Germain KOUASSI Kouassi , Armelle AKA ANY-GRAH Adjoua Sandrine , Ange KONAN Gbê Kouakou N’dri , Edwige ODOH Alida , Noël ZIRIHI Guédé 
Published: January 2025

Background : Many of the pharmaceutical drugs used to treat Bacterial dermatoses, are becoming less and less effective in the face of bacterial multi-resistance. The search for remedies based on medicinal plants is a necessity in the discovery of new antibiotics effective in the treatment of dermatoses, above all inflammatory dermatoses become very common.
Objective : To evaluate the antibacterial power of aqueous and ethanolics extracts of three medicinal plants used in traditional medicine by the Akyé people to treat inflammatory dermatoses.
Methods : Plant organs were harvested in the Mé area, dried to a constant weight and then ground to a fine powder. Extraction was then carried out using osmosed water and ethanol 96° The phytochemical screening of the extracts was carried out by colouring reactions. The aqueous and ethanolic plant extracts were tested In vitro against Staphyloccocus aureus and Pseudomonas aeruginosa.
Results : The phytochemistry screening revealed the presence of sterols and polyterpenes, polyphenols, alkaloids, flavonoids, tannins, quinones and saponosides. Antibacterial tests showed that the hydroethanol extracts were the most active, with Minimal Inhibitory Concentrations ranging from (0.048 to 06.25 mg/ml) and Minimal Bacterial Concentrations from (1.56 to 06.25 mg/ml). Of the two bacterial strains studied, Pseudomonas aeruginosa was the most sensitive to all the extracts. The antibacterial potentials thus highlighted by the values of the ratio between Minimal Bacterial Concentrations and Minimal Inhibitory Concentrations obtained indicated that all the extracts showed a high bactericidal activity (100%) on Pseudomonas aeruginosa compared with Staphylococus aureus.
Conclusion : The results provide a solid database for future pharmaceutical research and the development of dermatological treatments derived from natural sources. In addition, this work highlights the importance of traditional medicinal knowledge in modern healthcare and supports efforts to develop effective topical forms of dermatoses based on active plant extracts through galenic formulations.
Evaluation of the Contamination of Four Metal Trace Elements (ETM) of Tilapia Fish (Oreochromis niloticus) from Two Types of Fish Ponds in an Aquaculture Production Center in Côte d’Ivoire
Authors: Fréjus EHUI Edi Jean , Claude YA Kouame , Clément KOUASSI Kouassi 
Published: January 2025

Trace Metal Element (ETMs) pollution in fish farming is becoming a concern due to difficult production conditions. This study investigated the level of contamination by four trace metals: lead (Pb), mercury (Hg), arsenic (As) and cadmium (Cd). ETM research focused on Oreochromis niloticus from two types of fish ponds in the Haut-Sassandra region of Côte d'Ivoire. The health risk associated with tilapia consumption in this major production area was assessed. The concentration of Trace Metal Elements in fish was measured using a Perkin Elmer argon plasma emission spectrometer, Optima 3000 DV model. The physicochemical parameters of pond water were taken in situ with a multi-parameter. The physicochemical characteristics show that the Haut-Sassandra region is an area favorable to fish farming activity with a neutral pH, an average temperature of 30°C and a conductivity less than 300. As for ETMs, Low concentrations ranging from 0 to 0.040 mg/kg for tilapia, from 0 to 3.0147 mg/kg for sediments and from 0 to 0.3262 mg/kg for ponds water were observed in the matrices studied. Mercury and arsenic were found to be absent in Tilapia. The statistical analyzes carried out showed that the average concentrations of these ETMs are lower than the standards recommended by FAO and European Union. However, bioconcentration factors between 2 and 6 indicate that chemical pollutants in pond water and sediments have a negative impact on Oreochromis niloticus production, As for dam ponds / retentions basins, values less than 1 were obtained. This study reveals that the consumption of Tilapia from fish ponds in the Haut-Sassandra region could presents a low risk. The work has also shown that tilapia from bypass ponds / diversion basin are the most vulnerable to the ETMs studied.
Systematic Identification of Copositivity Groups in Standard Series Patch Testing Through Hierarchical Clustering
Authors: Yang Yul W. , Yiannias James A. , Voss Molly M. , Hall Matthew R. , Youssef Molly J. , Davis Mark D. P. , Voelker Dayne H. , Klanderman Molly C. , Mangold Aaron R. 
Published: August 2023

ImportancePatients are frequently copositive for multiple allergens simultaneously, either due to chemical similarity or simultaneous sensitization. A better understanding of copositivity groups would help guide contact avoidance.ObjectiveTo use patient data to systematically determine copositivity groups in the Mayo Clinic Standard Series.Design, Setting, and ParticipantsIn this retrospective cross-sectional analysis, the Mayo Clinic patch test database was queried for pairwise copositivity rates in the 80 allergen Mayo Clinic Standard Series between 2012 and 2021. Data were collected from 3 tertiary care sites of the Mayo Clinic Contact Dermatitis Group and a total of 5943 patients were included, comprising all patients undergoing patch testing to the Mayo Clinic Standard Series allergens.Main Outcomes and MeasuresCopositivity rates between every 2 allergens in the 80-allergen Mayo Clinic Standard Series were estimated. After background correction, copositivity rates were analyzed using unsupervised hierarchical clustering to systematically identify copositivity groups in an unbiased manner.ResultsOverall, 394 921 total patches were applied to 5943 patients (4164 [70.1%] women, 1776 [29.9%] men, with a mean [SD] age of 52.3 [18.8] years ), comprising 9545 positive reactions. After background correction based on overall positivity rates, hierarchical clustering revealed distinct copositivity groups. Many were supported by prior literature, including formaldehyde releasers, cobalt-nickel-potassium dichromate, acrylates, 3-dimethylaminopropylamine-amidoamine-oleamidopropyl dimethylamine, alkyl glucosides, budesonide-hydrocortisone-17-butyrate, certain fragrances, compositae-sesquiterpene lactone mix, mercapto mix-mercaptobenzothiazole, carba mix-thiuram mix, and disperse orange-p-phenylenediamine. However, novel associations were also found, including glutaraldehyde-sorbitan sesquioleate, benzalkonium chloride-neomycin-bacitracin, bronopol-methylchloroisothiazolinone-methylisothiazolinone, and benzoic acid-iodopropynyl butylcarbamate.Conclusions and RelevanceThis retrospective cross-sectional analysis found that copositivity rates varied between allergens; allergens with extremely high positivity rates demonstrated nonspecific copositivity to multiple other allergens. Background correction based on positivity rates followed by hierarchical clustering confirmed prior known copositivity groups, contaminants and/or excipients leading to copositivity, and novel associations to guide contact avoidance.
Fluctuations in Serum Creatinine Levels During Hospitalization and Long-Term End-Stage Kidney Disease and Mortality
Authors: Efros Orly , Beckerman Pazit , Basson Ayelet A. , Cohen Roy , Klang Eyal , Frenkel Nir Yael , Soffer Shelly , Barda Noam , Grossman Ehud 
Published: August 2023

ImportanceAcute kidney injury is associated with poor outcomes, but the clinical implication of reversible serum creatinine level fluctuations during hospitalization not necessarily defined as acute kidney injury is poorly understood.ObjectiveTo investigate the long-term outcomes of patients without previously diagnosed kidney disease who present with decreased kidney function and are subsequently discharged with apparently normal kidney function.Design, Setting, and ParticipantsA retrospective cohort study was conducted of patients hospitalized in a large tertiary hospital in Israel between September 1, 2007, and July 31, 2022. The study included patients admitted to an internal medicine ward. Patients had not undergone dialysis during the index hospitalization, had at least 3 creatinine tests performed during hospitalization, and had a discharge estimated glomerular filtration rate (eGFR) exceeding 60 mL/min/1.73 m2. Patients with preexisting chronic kidney disease were excluded.ExposureGlomerular filtration rate was estimated from serum creatinine values using the updated 2022 Chronic Kidney Disease Epidemiology Collaboration formula, and eGFR greater than 60 mL/min/1.73 m2 was regarded as normal. Exposure was defined based on the association between the first and last values determined during hospitalization.Main Outcomes and MeasuresAll-cause mortality in the year following the index hospitalization and end-stage kidney disease (ESKD) in the 10 years following the index hospitalization.ResultsA total of 40 558 patients were included. Median age was 69 (IQR, 56-80) years, with 18 004 women (44%) and 22 554 men (56%). A total of 34 332 patients (85%) were admitted with a normal eGFR and 6226 (15%) with decreased eGFR. Patients with decreased eGFR on presentation had an 18% increased mortality in the year following hospitalization (adjusted hazard ratio [AHR], 1.18; 95% CI, 1.11-1.24) and a 267% increased risk of ESKD in the 10 years following hospitalization (AHR, 3.67; 95% CI, 2.43-5.54), despite having been discharged with apparently normal kidney function. The highest risk was noted in patients who presented to the hospital with an eGFR of 0 to 45 mL/min/1.73 m2.Conclusions and RelevanceThe findings of this cohort study suggest that patients who present with decreased kidney function and are discharged without clinically evident residual kidney disease may be at increased long-term risk for ESKD and mortality.
Hospitalization, Critical Illness, and Mortality Outcomes of COVID‐19 in Patients With Rheumatoid Arthritis
Authors: Mehrotra‐Varma Jai , Kumthekar Anand , Henry Sonya , Fleysher Roman , Hou Wei , Duong Tim Q. 
Published: August 2023

ObjectiveTo investigate the clinical outcomes of patients with rheumatoid arthritis (RA) with COVID‐19.MethodsThis retrospective study consisted of 361 patients with RA+ and 45,954 patients with RA− (March 2020 to August 2022) who tested positive for SARS‐CoV‐2 by polymerase‐chain‐reaction in the Montefiore Health System, which serves a large low‐income, minority‐predominant population in the Bronx and was an epicenter of the initial pandemic and subsequent surges. Primary outcomes were hospitalization, critical illness, and all‐cause mortality associated with SARS‐CoV‐2 infection. Comparisons were made with and without adjustment for covariates, as well as with 1083 matched controls of patients with RA− and COVID‐19.ResultsPatients with RA+ and COVID‐19 were older (62.2 ± 23.5 vs. 45.5 ± 26.3; P < 0.001), were more likely females (83.1% vs. 55.8%; P < 0.001), were Black (35.5% vs. 30.3%; P < 0.05), and had higher rates of comorbidities (P < 0.05), hospitalization (52.4% vs. 32.5%; P < 0.005), critical illness (10.5% vs. 6.9%; P < 0.05), and mortality (11.1% vs. 6.2%; P < 0.01) compared with patients with RA− and COVID‐19. Patients with RA+ with COVID‐19 had higher odds of critical illness (adjusted odds ratio [aOR] = 1.46, 95% confidence interval [CI]: 1.09‐1.93; P = 0.008) but no differences in hospitalization (aOR = 1.18 [95% CI: 0.93‐1.49]; P = 0.16) and mortality (aOR = 1.34 [95% CI: 0.92‐1.89]; P = 0.10) after adjusting for covariates. Odds ratio analysis identified age, hospitalization status, female sex, chronic kidney disease, chronic obstructive pulmonary disease, and Black race to be significant risk factors for COVID‐19‐related mortality. Pre‐COVID‐19 steroid and biologic therapy to treat RA were not significantly associated with worse outcomes (P > 0.05). Outcomes were not different between patients with RA+ and propensity‐matched RA− controls (P > 0.05).ConclusionOur findings suggest that risk factors for adverse COVID‐19 outcomes were not attributed to RA per se but rather age and preexisting medical conditions of patients with RA.
Identifying and Exploring Synthetic Antiferromagnetic Skyrmions
Authors: Zhao Yuelei , Yang Sheng , Wu Kai , Li Shuang , Gao Yang , Hao Hongyuan , Zhang Xichao , Wang Shouguo , Liu Qingfang , Zhang Senfu , Chu Zhiqin , Åkerman Johan , Zhou Yan 
Published: August 2023

AbstractSynthetic antiferromagnetic (SAF) skyrmions are emerging as novel information carriers due to their high mobility and lack of a skyrmion Hall effect. However, distinguishing SAF skyrmions from their ferromagnetic counterparts using imaging techniques like magneto‐optical microscopy remains challenging. While the suppressed intrinsic skyrmion Hall effect (SkHE) has been commonly used to identify SAF skyrmions, it is important to note that other factors such as defect pinning and dipolar interaction can also lead to a suppressed SkHE. Therefore, there is an urgent need for a universal identification method that can reliably differentiate SAF skyrmions from ferromagnetic ones. In this study, the generation of a SAF skyrmion within a standard SAF stack is demonstrated and its motion with almost no SkHE is investigated. Furthermore, a universal identification method is proposed wherein the application of an out‐of‐plane field allows the SAF skyrmion to be decoupled into two domains, which can either expand or contract with the application of an electric current. By expediting the development of a reliable means of identifying SAF skyrmions, these findings will accelerate the realization of practical applications based on these unique information carriers.
Multi‐Material 3D Microprinting of Magnetically Deformable Biocompatible Structures
Authors: Pétrot Roxane , Devillers Thibaut , Stéphan Olivier , Cugat Orphée , Tomba Caterina 
Published: August 2023

AbstractTwo‐photon polymerization (2PP) allows precise 3D printing at the micrometer scale, and by associating it with magnetic materials, the creation of remotely actuatable micro‐structures. Such structures attract a growing interest for biomedical applications, thanks to their size and to the biocompatibility of some photoresist materials. Gelatin methacryloyl (Gel‐MA) is one such material, and can be used to create physiological scaffolds for cell culture. Here, the physico‐chemical properties of two resins are exploited, the first being a silica‐based hybrid polymer, the OrmoComp, and the second a Gel‐MA‐based hydrogel. A 2PP manufacturing protocol is defined and designed to print both materials in succession as a single structure, which is then linked to a neodymium‐iron‐boron (NdFeB) magnetic bead for actuation. By this combination, a magnetically deformable 3D culture substrate is created to study cells in an environment that mimics soft, curved, and dynamic properties of tissues in vivo. The structure is actuated via an external magnetic field and bends back and forth along its longest axis. Lastly, preliminary cell culture trials are conducted showing the proliferation of cells on the structures.
Indicator Sensor Development and Fuel Cell Degradation Imaging
Authors: Woo Sahng Hyuck , Lee Nak Jun , Yook Seung Ho , Kim Hee Soo , Choi Jieun , Kim Jae‐Hun , Lee So Young , Jang Jong Hyun , Yoo Sung Jong , Yoon Young‐Gi , Han Jonghee , Kim Hyoung‐Juhn 
Published: August 2023

AbstractAlthough extensive research has been conducted, understanding the exact phenomena occurring during the operation of polymer electrolyte fuel cells (PEFCs) remains difficult. This research attempted to identify new reasons for the reduced performance of PEFC using an imaging technique. To begin with, H+ and OH− indicator sensors, which display red, blue, and green values (RGB) using digital microscopes, are developed and attached to each electrode of a membrane electrode assembly to enable quantitative analysis of ion generation. The proposed reaction in the fuel cell can be confirmed, and various reactions occurring in the electrode can be examined using this approach. In particular, H+ is generated at the anode and cathode of the anion exchange membrane fuel cell, which is found to be a major cause of performance deterioration.
In Situ Formation of Coordinated Polymer via Organic–Inorganic Hybridization Engineering Boosting High‐Efficiency Potassium Storage
Authors: Liu Hang , Cheng Mengyuan , Tian Zhuocheng , Cui Lianmeng , Wu Di , Wang Dongxue , Zhou Liang , Xia Jianlong 
Published: August 2023

AbstractOrganic redox‐active molecules with merits of structure diversity and tunable properties are emerging as promising cathodes for the practical usage of potassium‐ion batteries (PIBs). However, the inferior cycle stability and sluggish charge‐carrier mobility are two main drawbacks hindering the practical application of organic cathode materials. Herein, highly conductive inorganic CuS is combined with small molecule‐based redox species (perylene‐3,4,9,10‐tetracarboxylic dianhydride, PTCDA) to form a novel organic–inorganic hybrid cathode (PTCDA/CuS) for PIBs, which could undergo electrochemical‐induced in situ self‐transformation of a sulfur‐linked and Cu2+‐coordinated PTCDA polymer (labeled as Cu@PTCDA‐SP). Benefiting from improved redox sites from activated carbonyl groups, high stability afforded by the sulfur‐bridging, isotropic amorphous nature, and 3D cross‐linked nanosheet morphologies, the resulting Cu@PTCDA‐SP cathode exhibits a high‐rate capacity involving trielectron enolization (vs 2‐electron transformation in PTCDA monomers) and long‐term cycle life (over 2800 cycles at 5 A g−1). This organic–inorganic hybridized cathode is very promising for PIBs. Additionally, the self‐transformation strategy provides new insight into the discovery of more electrochemically induced interaction between organic–inorganic hybrids toward high‐performance secondary batteries.
Modulation of Radical Intermediates in Rechargeable Organic Batteries
Authors: Gu Shuai , Chen Jingjing , Hussain Iftikhar , Wang Zhiqiang , Chen Xi , Ahmad Muhammad , Feng Shien‐Ping , Lu Zhouguang , Zhang Kaili 
Published: August 2023

AbstractOrganic materials have been considered as promising electrodes for next‐generation rechargeable batteries in view of their sustainability, structural flexibility, and potential recyclability. The radical intermediates generated during the redox process of organic electrodes have profound effect on the reversible capacity, operation voltage, rate performance, and cycling stability. However, the radicals are highly reactive and have very short lifetime during the redox of organic materials. Great efforts have been devoted to capturing and investigating the radical intermediates in organic electrodes. Herein, this review summarizes the importance, history, structures, and working principles of organic radicals in rechargeable batteries. More importantly, challenges and strategies to track and regulate the radicals in organic batteries are highlighted. Finally, further perspectives of organic radicals are proposed for the development of next‐generation high‐performance rechargeable organic batteries.