bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explaining the paradox of conspiracy theories and system‐justifying beliefs from an intergroup perspective
Authors: Mao Jia‐Yan , Zeng Zhao‐Xie , Yang Shen‐Long , Guo Yong‐Yu , van Prooijen Jan‐Willem 
Published: August 2023

AbstractBy distinguishing between ingroup versus outgroup conspiracy theories, this research seeks to explain a paradox in conspiracy theory research, namely, that conspiracy beliefs are associated with both derogation and justification of the social system. Study 1 (N = 1,481) was a survey in the context of the COVID‐19 pandemic in China, and the results revealed a negative correlation between belief in ingroup conspiracy theories and system‐justifying beliefs. In Study 2 (N = 195), exposure to outgroup conspiracy theories positively predicted system‐justifying beliefs, a finding that was serially mediated by external attributions and collective narcissism. In Study 3 (N = 256), exposure to ingroup conspiracy theories negatively predicted system‐justifying beliefs, a result that was serially mediated by internal attributions and anomie. In Study 4 (N = 616), exposure to a conspiracy theory about the US government increased system‐justifying beliefs among Chinese participants and decreased them among US participants. The distinction between ingroup versus outgroup conspiracy theories hence implies two different processes through which conspiracy theories affect system‐justifying beliefs.
Agricultural productivity‐environmental sustainability nexus through the lens of digitalization and energy intensity in BRICS countries
Authors: Qi Junkai , Hussain Jamal , Yin Yexing , Khan Anwar 
Published: August 2023

AbstractThe agricultural sector holds paramount implications in the economies of BRICS (Brazil, Russia, India, China, and South Africa) countries. Nevertheless, the escalating effect of climate change shows a significant and alarming threat to the actual environmental conditions required to sustain agricultural production. This study examines the potential contribution of demographic dividends, digitalization, and energy intensity in facilitating the attainment of environmental sustainability and agricultural productivity by BRICS economies from 1996 to 2020. The study first tested cross‐sectional dependence, then unit roots, cointegration, and long‐run elasticities using suitable econometric approaches to explore possible links between the study variables. The empirical results from the long‐run estimators stated that digitalization improves agricultural production and the environment; contrarily, demographic dividend and energy intensity contribute to environmental degradation. Furthermore, the long‐term improvement of agricultural production is supported by demographic dividend, GDP per capita, energy intensity, and digitalization. Also, the study reached a broad inference emphasizing bidirectional causal associations between demographic dividend, energy intensity, GDP per capita, the environment, and agricultural production. In conclusion, the study has identified robust policy options for BRICS economies that can serve as valuable guidance for policymakers in making informed decisions and implementing effective practices.
The association between appreciative management and work engagement among health‐ and social care professionals: A cross‐sectional study
Authors: Kuha Suvi , Rissanen Sanna , Harmoinen Merja , Vähänikkilä Hannu , Kanste Outi 
Published: August 2023

AbstractBackgroundThe importance of work engagement has been emphasised due to the increasing demand for health‐ and social care and the shortage of skilled labour. Improving organisational and managerial factors is important when enhancing professionals' work engagement. The association between management and work engagement has only been established in previous studies at a general level, but the association between appreciative management and work engagement has not received equivalent research interest.AimThis study aimed to describe the association between appreciative management and work engagement among health‐ and social care professionals.MethodsThe study used a cross‐sectional survey design. The data were collected in five health and social services centres in one city in Finland from September to October 2022 using the Appreciative Management Scale 2.0 and the Utrecht Work Engagement Scale‐9. A total of 182 health‐ and social care professionals participated. The data were analysed using correlations, linear regression analyses, independent samples t‐tests and two‐way analyses of variance (ANOVAs).ResultsA moderate association was found between appreciative management and work engagement and its dimensions of vigor, dedication and absorption. Systematic management had the strongest association and equality had the weakest association with work engagement. Among the dimensions of work engagement, appreciative management had the strongest association with vigour and the weakest association with absorption. Appreciative management and work type predicted 18% of the variance in work engagement. Full‐time employees reported higher levels of work engagement and all its dimensions than did part‐time employees.ConclusionThe results indicate that appreciative management and full‐time work predict work engagement among health‐ and social care professionals. Due to this positive association, it is important to promote managers' appreciative management skills by educating them to understand how appreciative management enables and supports professionals' vigour, dedication and absorption in health‐ and social care.
Dogmatism and perceptual justification: A reason‐theoretic foundation
Authors: Vahid Hamid 
Published: August 2023

AbstractAccording to one prominent account of perceptual justification, “dogmatism,” whenever you have perceptual experience as if p, and lack defeaters, you thereby have immediate, prima facie justification for believing that p. The most important challenge is to show how experience can, on its own, provide justification for the belief in its content. Dogmatists often try to meet this challenge by highlighting the phenomenal character of perceptual experience and the mode of presentation of its content and defending their justifying roles by appealing to intuitively plausible examples. What is lacking here, however, is a theoretical framework to sanction and justify those roles going beyond the mere appeal to examples. Finding such a framework is the main goal of this article. I begin by criticizing a prominent response to this challenge, which suggests a composition view of perceptual experience consisting of sensory experiences and seemings. I then highlight the need for a theoretical framework to provide the rationale for the justifying roles that dogmatists allocate to perceptual experience. It is claimed that the framework in question involves the mechanism by which we possess reasons. Adapting the framework to cases where perception functions as a reason, a principled defense of dogmatism is provided.
Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services
Authors: Tennakoon Gayani , Byrne Enda M. , Vaithianathan Rhema , Middeldorp Christel M. 
Published: August 2023

AbstractIntroductionIdentifying young people who are at risk of self‐harm or suicidal ideation (SHoSI) is a priority for mental health clinicians. We explore the utility of routinely collected data in developing a tool to aid early identification of those at risk.MethodWe used electronic health records of 4610 young people aged 5–19 years who were treated by Child and Youth Mental Health Services (CYMHS) in greater Brisbane, Australia. Two Lasso models were trained to predict the risk of future SHoSI in young people currently rated SHoSI; and those who were not.ResultsFor currently non‐SHoSI children, an Area Under the Receiver Operating Characteristics (AUC) of 0.78 was achieved. Those with the highest risk were 4.97 (CI 4.35–5.66) times more likely to be categorized as SHoSI in the future. For current SHoSI children, the AUC was 0.62.ConclusionA prediction model with fair overall predictive power for currently non‐SHoSI children was generated. Predicting persistence for SHoSI was more difficult. The electronic health records alone were not sufficient to discriminate at acceptable levels and may require adding unstructured data such as clinical notes. To optimally predict SHoSI models need to be tested and validated separately for those young people with varying degrees of risk.
Soil microorganisms increase Olsen phosphorus from poorly soluble organic phosphate: A soil incubation study
Authors: Velasco‐Sánchez Á. , Bennegadi‐Laurent N. , Trinsoutrot‐Gattin I. , van Groenigen J. W. , Moinet G. Y. K. 
Published: August 2023

AbstractThe potential shortage of mineral phosphorus (P) sources and the shift towards a circular economy motivates the introduction of new forms of P fertilizers in agriculture. However, the solubility of P in new fertilizers as well as their availability to plants may be low. In this experiment, we incubated an agricultural soil poor in P (28 mg P2O5 kg−1) for 63 days in the presence of a range of organic and inorganic poorly soluble P forms commonly found in new fertilizers: hydroxyapatite (P‐Ca), iron phosphate (P‐Fe), phytic acid (P‐Org) and a combination of P‐Ca and P‐Org (P‐Mix). Cellulose and potassium nitrate (KNO3) were added to stimulate microbial activity at the beginning of the incubation. We included a positive control with triple superphosphate (TSP) and negative controls with no P application (with and without cellulose and KNO3). We assessed the fate of the different poorly soluble P forms in NaHCO3 extracts (Olsen P) over time as a proxy for plant‐available P. Soil microbial biomass, fungal to bacterial ratio, soil respiration, enzymatic activities (β‐glucosidase, arylamidase and acid and alkaline phosphatase), N mineralization and soil pH were also monitored. At the beginning of the incubation, TSP showed the highest Olsen P across all treatments and P‐Fe showed higher levels of Olsen P than the other poorly soluble P forms (p < .05). During the incubation, the levels of Olsen P decreased over time for TSP (positive control). Contrastingly, Olsen P increased significantly over time for all the poorly soluble P forms and the negative controls, indicating an increase in plant‐available P. Particularly, levels of Olsen P for the P‐Org treatment roughly doubled (shifting from 16.5 mg kg−1 to 32.9 mg kg−1) over the whole incubation period. The rate of increase in Olsen P was positively correlated with microbial biomass C:P ratio (p < .01) for all poorly soluble treatments. The higher levels of Olsen P for the P‐Org treatment were also explained by a positive correlation with fungal biomass. Our results show that poorly soluble forms of P may be made available to plants under the influence of the microbial community, with a stronger effect on organic P forms.
Perceptions and attitudes of farmers and landowners on soil salinity management and use of elemental sulphur in Oman
Authors: Al‐Mayahi Ahmed , Al‐Shibli Noah , Gibreel Tarig , Blackburn Daniel , Al‐Ismaily Said , McHugh Caila 
Published: August 2023

AbstractSoil salinity threatens agricultural sustainability globally and is a significant challenge in Oman. Previous studies in Oman focused on examining the causality and spatiotemporal variation of groundwater and soil salinity, neglecting farmers' perceptions and attitudes towards salinity management. Therefore, this study evaluates (i) perceptions and attitudes of landowners and farmers towards soil salinity and its management, and (ii) determinants of willingness to use elemental sulphur to alleviate soil salinity in Oman. A questionnaire survey (122 responses) assessed perceptions, attitudes and knowledge using Likert scales and qualitative questions. Binary Logistic Regression analysed determinants of willingness to use elemental sulphur. Results reveal variations in perceptions, attitudes, knowledge and management practices. Most of the respondents were aware of adequate nutrient and water requirements for crops (p < .05). Respondents rely on social media (38.5%), fellow farmers (32.1%) and personal experiences (11.5%) for knowledge acquisition about soil salinity management. Half of the respondents did not monitor soil salinity, while the other half relied primarily on visual observation. A substantial number (62.6%) of the respondents did not implement any techniques to alleviate soil salinity, while among those who acted, a majority preferred cultivating date palms (55%) or fodders (29.4%). Awareness of the national salinity management strategy and commercial products is lacking. However, when introduced to elemental sulphur as a soil amendment for salinity, 74.8% of the respondents demonstrated a willingness to utilize it. Most (82.4%) preferred elemental sulphur products within the lowest price range. Being a full‐time farmer, owning a farm, awareness of the national strategy and low‐price preferences were positive determinants, while <1 year of farming experience was a negative determinant of willingness to use elemental sulphur. These findings inform future research on socio‐economic perceptions of salinity in Oman, the Gulf region and similar arid areas facing food production limitations.
Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum
Authors: Engel Anja J. , Paech Steffen , Langhans Markus , van Etten James L. , Moroni Anna , Thiel Gerhard , Rauh Oliver 
Published: August 2023

AbstractWhen the K+ channel‐like protein Kesv from Ectocarpus siliculosus virus 1 is heterologously expressed in mammalian cells, it is sorted to the mitochondria. This targeting can be redirected to the endoplasmic reticulum (ER) by altering the codon usage in distinct regions of the gene or by inserting a triplet of hydrophobic amino acids (AAs) into the protein's C‐terminal transmembrane domain (ct‐TMD). Systematic variations in the flavor of the inserted AAs and/or its codon usage show that a positive charge in the inserted AA triplet alone serves as strong signal for mitochondria sorting. In cases of neutral AA triplets, mitochondria sorting are favored by a combination of hydrophilic AAs and rarely used codons; sorting to the ER exhibits the inverse dependency. This propensity for ER sorting is particularly high when a common codon follows a rarer one in the AA triplet; mitochondria sorting in contrast is supported by codon uniformity. Since parameters like positive charge, hydrophobic AAs, and common codons are known to facilitate elongation of nascent proteins in the ribosome the data suggest a mechanism in which local changes in elongation velocity and co‐translational folding in the ct‐TMD influence intracellular protein sorting.
Sliding Pressure Inventory Control of a Supercritical CO2 Cycle for Concentrated Solar Power—Analysis and Implications
Authors: Seshadri Lakshminarayanan , Kumar Pramod 
Published: August 2023

Abstract
This paper presents the use of sliding pressure inventory control (SPIC) of a 10 MW supercritical carbon dioxide Brayton cycle for concentrated solar power, incorporating printed circuit heat exchangers. Load regulation using SPIC for three representative ambient conditions 45 °C, 30 °C, and 15 °C are considered. While a wide operating range from 10 MW to less than 1 MW part load is obtained, a notable cycle efficiency decline at part load is also seen. Irreversibility analysis reveals that deterioration in recuperator and turbomachinery performance are primarily responsible for cycle performance degradation at part load. Nevertheless, useful inferences are obtained from the 10 MW SPIC irreversibility study. With a slightly increased value of heat exchanger length, a non-condensing 1 MW subcritical CO2 cycle operating between 35 bar/53 bar is found to be as efficient as a 1 MW supercritical CO2 cycle operating between 88 bar/210 bar. The major benefit of choosing the subcritical CO2 cycle for 1 MW scale applications is the significantly reduced turbomachinery speed (∼26,000 rpm) in comparison with supercritical CO2 turbomachinery (∼67,000 rpm) for the same power scale. These advantages are found to be true for air-based ideal gas cycles operating between 35 bar/53 bar too, with the latter requiring nominally smaller heat exchangers than the subcritical CO2 cycle. The final choice of working fluid, however, for these low-pressure cycles would depend on practical considerations, such as material compatibilities at high temperatures, corrosion considerations, and cost.
Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A
Authors: Sun Nan , Zhang Jikai , Zhang Chen , Xie Tan , Zhang Zeyu , Wang Xueyan , Li Wanjing , Zhang Yi , Chen Zhaokai , Zheng Junnian , Fang Lin , Wang Gang 
Published: August 2023

ABSTRACT

Human adenovirus (HAdV) is ubiquitous in the human population, constituting a significant burden of global respiratory diseases. Children and individuals with low immunity are at risk of developing severe infections without approved antiviral treatment for HAdV. Our study demonstrated that TRIM35 inhibited HAdV-C5 early gene transcription, early protein expression, genome replication, and infectious virus progeny production. Furthermore, TRIM35 was found to inhibit HAdV replication by attenuating E1A expression. Mechanistically, TRIM35 interacts with and degrades E1A by promoting its K48-linked ubiquitination. Additionally, K253 and K285 are the key sites necessary for TRIM35 degradation. Moreover, an oncolytic adenovirus carrying shTRIM35 was constructed and observed to exhibit improved oncolysis
in vivo
, providing new ideas for clinical tumor treatment. Our results expand the broad antiviral activity of TRIM35 and mechanically support its application as a HAdV replication inhibitor.

IMPORTANCE
E1A is an essential human adenovirus (HAdV) protein responsible for the early replication of adenovirus while interacting with multiple host proteins. Understanding the interaction between HAdV E1A and TRIM35 helps identify effective antiviral therapeutic targets. The viral E1A protein is a crucial activator and regulator of viral transcription during the early infection stages. We first reported that TRIM35 interacts with E1A to resist adenovirus infection. Our study demonstrated that TRIM35 targets E1A to resist adenovirus, indicating the applicability of targeting virus-dependent host factors as a suitable antiviral strategy.
The atlastin ER morphogenic proteins promote formation of a membrane penetration site during non-enveloped virus entry
Authors: Pletan Madison , Liu Xiaofang , Cha Grace , Chen Yu-Jie , Knupp Jeffrey , Tsai Billy 
Published: August 2023

ABSTRACT

During entry, non-enveloped viruses penetrate a host membrane to cause infection, although how this is accomplished remains enigmatic. Polyomaviruses (PyVs) are non-enveloped DNA viruses that penetrate the endoplasmic reticulum (ER) membrane to reach the cytosol
en route
to the nucleus for infection. To penetrate the ER membrane, the prototype PyV simian virus 40 (SV40) induces formation of ER-escape sites, called foci, composed of repeating units of multi-tubular ER junctions where the virus is thought to exit. How SV40 triggers formation of the ER-foci harboring these multi-tubular ER junctions is unclear. Here, we show that the ER morphogenic atlastin 2 (ATL2) and ATL3 membrane proteins play critical roles in SV40 infection. Mechanistically, ATL3 mobilizes to the ER-foci where it deploys its GTPase-dependent membrane fusion activity to promote formation of multi-tubular ER junctions within the ER-foci. ATL3 also engages an SV40-containing membrane penetration complex. By contrast, ATL2 does not reorganize to the ER-foci. Instead, it supports the reticular ER morphology critical for the integrity of the ATL3-dependent membrane complex. Our findings illuminate how two host factors play distinct roles in the formation of an essential membrane penetration site for a non-enveloped virus.

IMPORTANCE

Membrane penetration by non-enveloped viruses, a critical infection step, remains enigmatic. The non-enveloped PyV simian virus 40 (SV40) penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol
en route
for infection. During ER-to-cytosol membrane penetration, SV40 triggers formation of ER-associated structures (called ER-foci) that function as the membrane penetration sites. Here, we discover a role of the ATL ER membrane proteins—known to shape the ER morphology—during SV40-induced ER-foci formation. These findings illuminate how a non-enveloped virus hijacks host components to construct a membrane penetration structure.
Nuclear proinflammatory cytokine S100A9 enhances expression of human papillomavirus oncogenes via transcription factor TEAD1
Authors: Mori Seiichiro , Ishii Yoshiyuki , Takeuchi Takamasa , Kukimoto Iwao 
Published: August 2023

ABSTRACT

Transcription of the human papillomavirus (HPV) oncogenes,
E6
and
E7
, is regulated by the long control region (LCR) of the viral genome. Although various transcription factors have been reported to bind to the LCR, little is known about the transcriptional cofactors that modulate HPV oncogene expression in association with these transcription factors. Here, we performed
in vitro
DNA-pulldown purification of nuclear proteins in cervical cancer cells, followed by proteomic analyses to identify transcriptional cofactors that bind to the HPV16 LCR via the transcription factor TEAD1. We detected the proinflammatory cytokine S100A9 that localized to the nucleus of cervical cancer cells and associated with the LCR via direct interaction with TEAD1. Nuclear S100A9 levels and its association with the LCR were increased in cervical cancer cells by treatment with a proinflammatory phorbol ester. Knockdown of S100A9 decreased HPV oncogene expression and reduced the growth of cervical cancer cells and their susceptibility to cisplatin, whereas forced nuclear expression of S100A9 using nuclear localization signals exerted opposite effects. Thus, we conclude that nuclear S100A9 binds to the HPV LCR via TEAD1 and enhances viral oncogene expression by acting as a transcriptional coactivator.

IMPORTANCE

Human papillomavirus (HPV) infection is the primary cause of cervical cancer, and the viral oncogenes
E6
and
E7
play crucial roles in carcinogenesis. Although cervical inflammation contributes to the development of cervical cancer, the molecular mechanisms underlying the role of these inflammatory responses in HPV carcinogenesis are not fully understood. Our study shows that S100A9, a proinflammatory cytokine, is induced in the nucleus of cervical cancer cells by inflammatory stimuli, and it enhances HPV oncogene expression by acting as a transcriptional coactivator of TEAD1. These findings provide new molecular insights into the relationship between inflammation and viral carcinogenesis.