bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved policy making through enhanced dialogue and focused education
Authors: Muzyka Pavlo , Filyak Maksym 
Published: March 2023

The purpose of the paper is to show ways of strengthening civil society’s capacities and contribute to improvement of transparency of implementation of sectoral economic strategies at the level of Lviv Region of Ukraine and its 20 districts by supporting local authorities in their interaction. Specifically, it addresses itself on the following scientific objectives, namely, to show increase of public awareness at district, regional and national levels on the process of district and regional budget approval and spending; to demonstrate ways of assuring better involvement of civil society actors (NSA) in policy dialogue with public authorities (LA) on implementation of sector strategies in the following areas: regional development, rural development; and, finally, to comment on methods of strengthening CSO capacities to promote reform and increase public accountability in monitoring the management of public finance. The article presents findings from the research that covered 500 representatives of district level NSA and LA of the region, 100 region-level NSA-LA activists, and was intended to develop the abovementioned model, to benefit over 5000 people (NGOs, LAs, government) as a result, with information coverage to reach at least 15000 people. Results of the research showed that the efforts of this initiative will likely lead to the achievement of the following results in 2–3 years, including the transparency of budgeting is improved and lead to allocating district strategy funds in a better way; the dialogue between NSA and LA at regional and district level in the target region on particular Issues of implementation of sectoral strategies is existing; and, finally, effective and transparent strategies/ instruments of monitoring the management of public funds are researched and developed, CSOs in Lviv region and ist districts are using those strategies/instruments. Apart from being purely educational, the abovementioned model has a dimension allowing to provide small grants and organize exchange programs in order to strengthen institutional potential of local governments and ensure revitalization of human capital, especially on conflict-affected territories. Activities in the framework of this dimension or cluster should be provided in several stages. All the activities should be focused on improving policy making process of local governments in target regions. A pilot research of community attitudes has been held in 2014–2015 where, by means of Participatory Action Research, the authors have identified issues to be addressed and gaps in existing interaction mechanisms between NSA and LA at district level, and recommendations identifying the problem to be addressed by the current proposal have been drafted in direct consultation with the target groups and final beneficiaries. The research has allowed to structure cause-effect interconnections and activity clusters in this educational development project.
Вплив соціальної відповідальності на формування навичок здобувачів вищої освіти
Authors: Lunkina Tetyana 
Published: March 2023

У статті досліджено сутність соціальної відповідальності і її вплив на формування навичок здобувачів вищої освіти. Проаналізовано глобальні фактори змін щодо формування навичок у суспільстві, основні навички здобувачів вищої освіти у 2015 р. і навички, які будуть мати популярність у 2020 р. Деталізовано навички здобувачів вищої освіти, якими найкраще та найгірше володіють випускники ВНЗ України у 2016 р.
Formulary Management of Biologics in Plaque Psoriasis
Authors: Vannabouathong Chris , Dyrda Peter 
Published: March 2023

Unlike the new-generation biologics (interleukin [IL]-17 and IL-23 inhibitors), all old-generation biologics (anti–tumour necrosis factor [TNF] and anti–IL-12/23 biologics) for plaque psoriasis (PsO) have now lost their exclusivity status and most were launched prior to the pan-Canadian Pharmaceutical Alliance. In addition, biosimilar versions of the old-generation biologics have had limited uptake and delayed launches in Canada spanning multiple years, suggesting a significant opportunity cost paid for these drugs after loss of exclusivity.
Modern clinical evidence, which is more rigorous than the evidence supporting the old-generation drugs and includes head-to-head trials comparing IL-17 and IL-23 inhibitors with anti-TNF and anti–IL-12/23 biologics, have demonstrated greater efficacy with the new-generation biologics.
In Canada, despite access to newer and more efficacious treatments, physicians continue to prescribe old-generation drugs to patients newly initiating a biologic for PsO (25% of patients in 2020), and the new-generation biologics are also less costly on an average per patient basis at list price compared with the most utilized old-generation biologic (ustekinumab).
Public payers have spent $28 million (at list price) on biologics initiated for PsO beyond their loss of exclusivity from 2016 to 2020 ($600 million for biologics initiated for any indication), and that figure is likely much higher today. Notably, some IL-17 biologics will lose data protection within the next 2 years, which will further increase this opportunity cost.
It is prudent that decision-makers review the place in therapy of biologics for PsO. Based on the findings of this report, the policy recommendation is to assess the clinical and economic value of old-generation biologics in the context of current evidence standards in PsO. The promotion of the use of new-generation biologics should be considered by payers to support the appropriate use of biologics in PsO, which would improve patient outcomes with budget savings or neutrality (assuming no confidential pricing agreements with the old-generation biologics) versus the status quo.
Tingkatkan Pengetahuan Dan Kepedulian Organisasi Gerakan Kepemudaan Dalam Pembangunan Desa Melalui Sekolah Kader Penggerak Desa
Authors: Niken Lestari  
Published: March 2023

ABSTRACT: Village development plays an important role for the advancement of a nation because it is an inseparable part of regional and national development. An Islamic youth movement organization whose majority of its members are young people is part of the community that should participate in village development. To foster this spirit, a village driving cadre school was held. The method used in carrying out this community service is socialization and discussion. The stages of implementing village driving cadres are the stages of planning activities, implementation activities, and evaluations. The results of this activity are expected to increase youth awareness in exploring village potential and play an active role in village development.
Keywords: Youth, Village Movement Cadre School, Village Development

ABSTRAK: Pembangunan desa memegang peranan penting bagi majunya sebuah bangsa karena merupakan bagian yang tidak dapat terpisahkan dengan pembangunan daerah maupun nasional. Organisasi gerakan pemuda Islam yang mayoritas anggotanya kaum muda merupakan bagian dari masyarakat yang seharusnya ikut serta berpartisipasi dalam pembangunan desa. Untuk menumbuhkan semangat tersebut diadakanlah sekolah kader penggerak desa. Metode yang digunakan dalam melaksanakan pengabdian masyarakat ini adalah sosialisasi dan diskusi. Tahapan-tahapan pelaksanakan kader penggerak desa adalah tahap kegiatan perencanaan, kegiatan pelaksanaan, dan evaluasi. Hasil dari kegiatan ini diharapkan dapat meningkatkan kesadaran pemuda dalam menggali potensi desa dan berperan aktif dalam pembangunan desa.
Kata Kunci: Pemuda, Sekolah Kader Penggerak Desa, Pembangunan Desa
Life Is Not a Machine or a Ghost: The Naturalistic Origin of Life’s Organization and Goal-Directedness, Consciousness, Free Will, and Meaning
Authors: Enright Marsha Familaro 
Published: March 2023

ABSTRACTDue to a widespread belief in mechano-reductionism, most intellectuals reject the idea that nonconscious living beings act toward goals. Proposing otherwise is mostly rejected as unscientific anthropomorphizing or necessitating appeals to a supernatural power. This false dichotomy has stymied biology and its related sciences. Herein, I present a new naturalistic gestalt on the nature of life—one based on facts and evidence. It incorporates Ludwig von Bertalanffy’s and Arthur Koestler’s theories of systems and hierarchies with the ideas of Aristotle, Hans Jonas, and Ayn Rand, to identify fundamental formulations on the nature of life, consciousness, free will, and meaning.
REALIZATION OF THE EXPORT POTENTIAL OF THE SOCIO-ECONOMIC DEVELOPMENT OF THE DEPRESSED REGION ON THE BASIS OF THE PROJECT APPROACH
Authors: Мокрушин А.А. , Рычковская Д.Н. 
Published: March 2023

Статья посвящена изучению региональных аспектов активизации внешнеэкономической деятельности на основе проектного подхода. Представлены результаты анализа экспортной деятельности предприятий Республики Адыгея, относящейся к группе регионов депрессивного типа Юга России. Раскрыта товарная структура экспортно-импортных операций предприятий Республики Адыгея, основные направления экспорта конкурентоспособной продукции. Выделены стратегические задачи и инструменты реализации экспортного потенциала региона в соответствии со Стратегией социально-экономического развития Республики Адыгея до 2030 года. Систематизированы проблемы реализации национальных и региональных проектов развития социально-экономического комплекса депрессивного региона. Дана оценка роли региональных проектов в развитии экспортной деятельности депрессивного региона. Раскрыты организационно-экономические аспекты реализации региональных проектов, направленных на развитие экспортоориентированных производств в Республике Адыгея. Выделены ключевые недостатки проектной деятельности по реализации экспортного потенциала депрессивного региона, предложены направления активизации внешнеэкономической деятельности, меры государственной поддержки экспортоориентированных производств в Республике Адыгея
The article is devoted to the study of regional aspects of the activation of foreign economic activity on the basis of the project approach. The results of the analysis of the export activity of enterprises in the Republic of Adygea, belonging to the group of depressed regions of the South of Russia, are presented. The article reveals the commodity structure of export-import operations of enterprises of the Republic of Adygea, the main directions of export of competitive products. The strategic tasks and instruments for realizing the export potential of the region are highlighted in accordance with the Strategy of Socio-Economic Development of the Republic of Adygeauntil 2030. The problems of implementing national and regional projects for the development of the socio-economic complex of a depressed region are systematized. The role of regional projects in the development of export activities of the depressed region is assessed. The organizational and economic aspects of the implementation of regional projects aimed at the development of export-oriented industries in the Republic of Adygeaare disclosed. The key disadvantages of the project activity for the realization of the depressed region’s export potential are highlighted, the directions of activation of foreign economic activity, measures of state support for export-oriented industries in the Republic of Adygea are proposed
PROBLEMS AND PROSPECTS OF INTERACTION BETWEEN THE TOURIST-RECREATIONAL AND AGRO-INDUSTRIAL COMPLEX OF THE DEPRESSED REGION
Authors: Тамов А.А. , Бабалян Э.Б. , Хатукай С.А. 
Published: March 2023

В современных условиях интеграционное взаимодействие агропромышленного и туристско-рекреационного комплексов депрессивного региона может стать обладающей мультипликационным эффектом «точкой роста» его экономики, позволяющей более рационально и эффективно использовать имеющийся природно-ресурсный и производственный потенциал. В статье рассмотрено современное состояние агропромышленного и туристско-рекреационного комплексов Республики Адыгея, систематизированы региональные особенности, стимулирующие и сдерживающие их развитие, определены перспективы их взаимодействия. Установлено, что одним из перспективных направлений взаимодействия агропромышленного и туристско-рекреационного комплексов Республики Адыгея и диверсификации ее экономики является развитие сельского туризма. Выявлены основные эффекты развития сельского туризма в Республике Адыгея для различных экономических субъектов, а также ключевые проблемы, сдерживающие его развитие в регионе
In modern conditions, the integration interaction of agro-industrial and tourist-recreational complexes of a depressed region can become a "growth point" of its economy with a multiplier effect, allowing for more rational and efficient use of the existing natural resource and production potential. The article examines the current state of the agro-industrial and tourist-recreational complexes of the Republic of Adygea, systematizes the regional features that stimulate and restrain their development, and defines the prospects for their interaction. It is established that one of the promising areas of interaction between the agro-industrial and tourist-recreational complexes of the Republic of Adygea and the diversification of its economy is the development of rural tourism. The main effects of the development of rural tourism in the Republic of Adygeafor various economic entities, as well as the key problems hindering its development in the region are identified
Hypertension and epistaxis a co-relation
Authors: Neeshu Neeshu , Kashyap Sudarshan 
Published: March 2023

Introduction: Epistaxis is the most common otorhinolaryngological emergency. Whether there is an association relationship between epistaxis and hypertension is a subject of longstanding controversy. Objective: The aim of our study is to evaluate the relationship between epistaxis and hypertension. Materials and methods: This study was conducted at,U.P during the period between June 2016 and January 2017. A total of 40 patients were divided into two groups: Group A consisted of 20 patients who presented with epistaxis, and Group B consisted of 20 patients who served as a control group. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed for all patients. Patients were followed up for a period of two months. Results: Readings of blood pressure (BP) were similar between the two groups regarding BP at presentation, ABPM, and BP at two months. There was a higher number of attacks in patients with history of hypertension. There was highly significant positive correlation between number of attacks of epistaxis and BP readings. Systolic BP at presentation was higher in patients who needed more complex interventions such as pack or cautery than those managed by first aid. Conclusion: We found no definite association between epistaxis and hypertension.
FATORES ASSOCIADOS À DEPRESSÃO GESTACIONAL
Authors: Nascimento de Albuquerque Roberto , De Souza Leite Mylena Gabriella 
Published: March 2023

Este trabalho tem como objetivo verificar os fatores associados à depressão gestacional. Trata-se de uma revisão integrativa de literatura de artigos publicados nos últimos cinco anos nas bases de dados BVS, SciELO e Periódico Capes. Dos 392 artigos encontrados, 09 foram selecionados para essa pesquisa. Os principais fatores de risco verificados foram a baixa renda, desemprego, vivência de situações de violência física e psicológica, alterações no padrão de sono durante a gravidez e uso de álcool, tabaco e outras drogas, além de histórico prévio de depressão. O manejo adequado e precoce da depressão durante o período gestatório é essencial para evitar complicações e exacerbação do transtorno, bem como, depressão pós-parto e psicose puerperal. Não se deve negligenciar ou normalizar sintomas depressivos durante a gestação, é necessário investigar esses sintomas como forma de prevenir futuros agravos.
RELATO DE CASO DE HIDRONEFROSE EM PACIENTE ADULTA COM EVOLUÇÃO DESFAVORÁVEL
Authors: GARCIA Gabriella Barbosa , AGUIAR Gabriella Belotti de , DANZIGER Leila Rodrigues , LEITE Thyara Jaqueline 
Published: March 2023

A palavra ectasia define uma dilatação anormal de um órgão oco, de um canal glandular ou de um vaso. No contexto do trato urinário, entende-se por ectasia pielocalicial ou hidronefrose, a ocorrência de uma dilatação do sistema coletor renal, ou seja, dos cálices e da pelve renal. Tal afecção, com diagnóstico comum em pacientes pediátricos, pode ser uni ou bilateral e é devida a múltiplos fatores, que podem ser obstruções ou refluxos, responsáveis por acúmulo de urina e consequente aumento do volume renal. Isso pode acarretar situações de insuficiência grave deste órgão caso a patologia de base não seja tratada em tempo hábil. Nesta condição, nota-se a importância do diagnóstico e tratamento precoces para que o prognóstico possa ser o melhor possível diante de cada caso e para que o rim e o funcionamento de todo aparelho urinário sejam preservados. Neste sentido, este trabalho pretende descrever um caso clínico de hidronefrose com evolução insatisfatória devido diagnóstico tardio. À época (do diagnóstico), o estado avançado da patologia tornou necessária a nefrectomia – uma conduta extrema para essas situações. Relato: Paciente de 40 anos, sexo feminino, com diagnóstico de dilatação do sistema pielocalicial à direita, aos 18 anos de idade, que evoluiu de maneira insatisfatória e culminou com realização de nefrectomia direita, aos 21 anos, devido perda da função renal consequente ao diagnóstico tardio. Conclusão: De acordo com a literatura, o tratamento preconiza intervenção precoce na doença de base causadora da dilatação para prevenir a piora do quadro e evitar um pior prognóstico para o paciente.
A Comprehensive Review of the Free Piston Engine Generator and Its Control
Authors: Brosnan Patrick , Tian Guohong , Montanaro Umberto , Cockerill Sam 
Published: March 2023

Review A Comprehensive Review of the Free Piston Engine Generator and Its Control Patrick Brosnan 1, Guohong Tian 1, * , Umberto Montanaro 1, and Sam Cockerill 2 1 School of Mechanical Engineering Sciences, University of Surrey, Surrey GU2 7XH, UK 2 Libertine FPE Ltd., Sheffield S9 1DA, UK * Correspondence: g.tian@surrey.ac.uk; Tel.: +44-1483-300-800 Received: 2 February 2023 Accepted: 10 March 2023 Published: 23 March 2023 Abstract: The Free Piston Engine (FPE) is a unique machine with a higher thermal efficiency than its counterpart, the Conventional Reciprocating Piston Engine (CPE). The unique piston motion of the FPE is not constrained kinematically like the CPE with its connecting crankshaft and rotational inertial masses. Moreover, when directly coupled to the Linear Electric Machine (LEM) to harness electric energy production, the Free Piston Engine Generator’s (FPEG) characteristic motion, now being dynamically constrained, permits an extensive range of piston trajectory profiles to be exploited during operation. In addition, exploring varied piston trajectories during the development stages may be vital in reducing in-cylinder combustion emissions through strategies such as Low-Temperature Combustion (LTC) and Homogeneous Charge Compression Ignition (HCCI). This review paper will focus on the key motivations and drivers for continued FPEG development. It will also highlight and review its distinct advantages and challenges in being a viable solution as a future zero-carbon engine technology. Finally, FPE fundamentals, alongside its rich history, will be introduced, clearly presenting how academia and industry have described and controlled its intrinsic non-linear dynamics.
Tingkat Kreativitas Mengajar Guru Penjas Pada Jenjang Sekolah Dasar Di Kabupaten Pringsewu
Authors: Armanjaya Satria , Ziko Fajar Ramadhan  , Fadlu Rachman  , Felinda Sari  , Andri Prasetiyo  , Ahmad Nuruhidin  
Published: March 2023

Pendidikan yang berkualitas diharapkan tujuan pendidikan nasional dapat tercapai. Tujuan penelitian ini Mengevaluasi faktor orisinilitas kreativitas guru PJOK pada Sekolah Dasar, mengevaluasi faktor elaborasi kreativitas guru PJOK pada Sekolah Dasar, mengevaluasi faktor fleksibilitas kreativitas guru PJOK pada Sekolah Dasar di Kabupaten Pringsewu. Pendekatan penelitian ini mix methode desain penelitian evaluasi kreativitas guru PJOK. Sumber data pada penelitian ini Kepala Sekolah, Guru PJOK, dan Siswa SD di Kabupaten Pringsewu. Teknik pengumpulan data kuisioner, observasi, wawancara dan dokumentasi. Data yang diperoleh dianalisis secara kualitatif dengan langkah-langkah sebagai berikut: pengumpulan data; reduksi data; penyajian data; menarik kesimpulan. Hasil penelitian Faktor orisinalitas hasil perhitungan reliabilitas dari butir item pernyataan kreativitas guru PJOK yang telah di uji cobakan r<0,62 interpretasi lemah. Faktor elaborasi kreativitas guru PJOK yang telah di uji cobakan r<0,49 interpretasi lemah. Faktor fleksibilitas kreativitas guru PJOK yang telah di uji cobakan r<1,04 interpretasi terkategori istimewa. Hal tersebut disebabkan guru PJOK melakukan variasi dalam pemanasan tidak pasif. Saat pemberian materi pembelajaran guru PJOK memberikan gerak dasar terlebih dahulu seperti gerak lokomotor non lokomotor dan manipulatif. Simpulkan kreativitas guru PJOK sudah menerapkan faktor fleksibilitas dengan baik. dalam penerapan faktor orisinalitas dan elaborasi guru PJOK di Kabupaten Pringsewu masih lemah
Flow cytometry and chromosome numbers variation in argan tree Argania spinosa (L.) Skeels
Authors: EL BOUKHARI Ali , TABI Salma , EL MOUSADIK Abdelhamid , EL BOULLANI Rachida , TAHIRI Abdelghani , KOUFAN Meriyem , BENYAHIA Hamid , BOUHARROUD Rachid , AIT AABD Naima 
Published: March 2023

Argania spinosa L. Skeels is an endemic species of west-central Morocco, which is characterized by a high diversity of morphological and genetic traits. It constitutes a natural resource for oleo-agro-sylvo-pastoral uses. All conservation and genetic breeding strategies aimed to domesticate argan require a good knowledge of the plant material. However, several studies focused on agronomical, morphological, phytochemical, and molecular characterization, while the cytogenetic aspects were less investigated. The objective of this work is to identify the chromosome number and ploidy level on the national argan collection at the Agadir Regional Agronomic Research Center, Morocco. The determination of the chromosome number was carried out on root tips of germinated seeds collected from five trees genotypes selected on various morphological aspects. As a result, chromosome count on active root tip cells showed variation in the number (2n = 20; 2n = 22; 2n = 24) with a stable ploidy level (2n = 2x) that is confirmed by flow cytometry. These results combine two previous findings (2n=20, 2n=24) and reveal a third existence of twenty-two chromosome. As a conclusion, A. spinosa has three chromosomal numbers which represent the genetic diversity of the chromosomal number that this species exhibits. More studies are required to explain this variation on chromosome numbers for future breeding programs and to avoid incompatibilities.