bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the sequential and the repetitive Cpk sampling plans
Authors: Costa Antonio Fernando Branco 
Published: June 2023

AbstractThe index Cpk was created to quantify the ability of the process to produce products within the upper and lower specified limits (USL/LSL); but in the last two decades, the sample estimator of the capability index Cpk has also been used to decide whether a lot should be accepted or not; if the value of a sample of size n, randomly taken from the lot, is lower/larger than a threshold, then the lot is rejected/accepted. The sampling plan based on the value is known as the Cpk sampling plan. In recent publications, the Cpk sampling plan has been combined with the repetitive sampling scheme. In short, with the repetitive sampling scheme the Cpk sampling plan might be applied m times, consequently, the lot has m chances to be accepted; if the Cpk sampling plan is applied m times and the lot is not accepted, then the lot is finally rejected. The average number of inspected items per lot (ANI) the repetitive Cpk sampling plan (where m > 1) requires to decide whether the lot should be accepted or not is larger than the sample size n of the standard Cpk sampling plan (where m = 1), because of that the repetitive sampling strategy is not recommended. In this article, we propose the sequential Cpk sampling plan where the is compared with two thresholds (c1; c2) with c1 < c2; if the is lower (larger) than c1 (c2), then the lot is rejected (accepted); otherwise, the decision is left to the next sample. The ANI of the sequential Cpk sampling plan is a function of c1 and c2; depending on the choice of these two design parameters, the ANI of the sequential Cpk sampling plan is substantially lower than the sample size n of the standard Cpk sampling plan.
Sublimation application of 5‐chloro‐2‐mercaptobenzothiazole matrix for matrix‐assisted laser desorption/ionization mass spectrometry imaging of mouse kidney
Authors: Yousefi‐Taemeh Maryam , Duli Ergi , Dabija Laurentiu G. , Lemaire Mathieu , Ifa Demian R. 
Published: June 2023

RationaleSublimation is a solvent‐free technique used to apply a uniform matrix coating over a large sample plate, improving the matrix’s purity and enhancing the analyte signal. Although the 5‐chloro‐2‐mercaptobenzothiazole (CMBT) matrix was introduced years ago, there are no reports of its application via sublimation. We investigated the experimental parameters that are optimal for CMBT matrix sublimation on mouse kidney samples. We also evaluated the stability of the sublimed CMBT matrix under a vacuum environment. Using kidney samples prepared with a sublimated CMBT matrix, we conducted matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) analysis of specific phospholipids (phosphatidylcholine and phosphatidylglycerol in the positive ion mode and phosphatidylinositol in the negative ion mode). We also explored various spatial resolutions (50, 20, and 10 μm) and performed sequential MALDI–hematoxylin and eosin (H&E) staining.MethodsThe CMBT matrix was applied to kidney samples using a sublimation apparatus connected to a vacuum pump to achieve a pressure of 0.05 Torr. The matrix was then subjected to different temperatures and sublimation times to determine the optimal conditions for matrix application. Subsequently, a Q‐Exactive mass spectrometer equipped with a Spectroglyph MALDI ion source was employed for MALDI‐MSI experiments. Standard protocols were followed for H&E staining after MALDI analysis.ResultsA matrix thickness of 0.15 mg/cm2 yielded high‐quality images. The sublimated matrix exhibited minimal loss after approximately 20 h of exposure to a vacuum of 7 Torr, indicating its stability under these conditions. Ion images were successfully obtained at spatial resolutions of 50, 20, and 10 μm. Furthermore, orthogonal histological information was obtained through sequential MALDI‐H&E staining.ConclusionsWe demonstrate that samples prepared for MALDI‐MSI using sublimation to apply the CMBT matrix yield high‐quality mass spectrometric images of mouse kidney sections. We also provide data for the impact of various experimental parameters on image quality (e.g., temperature, time, matrix thickness, and spatial resolution).
Endobronchial indocyanine green instillation to identify the intersegmental plane for successful segmentectomy
Authors: Lilburn Paul , Kwan Jonathan , Williamson Jonathan , Ho‐Shon Kevin , Azari Mohammad , Wilson Michael , Ing Alvin , Saghaie Tajalli 
Published: June 2023

AbstractThe traditional indications for lobectomy for resectable Non‐small Cell Lung Cancer (NSCLC) may be set to change. Recently, anatomical segmentectomy (AS) versus lobectomy as an approach for early‐stage NSCLC has been described in phase 3 randomised controlled trials. The demand for methods to facilitate AS may increase as a consequence. We describe three cases of AS using the combination of endobronchial infiltration of indocyanine green (ICG) to identify the intersegmental plane (critical for the performance of AS), and Computed Tomography (CT) guided methylene blue injection for lesion localisation. The operations were completed successfully demonstrating satisfactory post‐operative outcomes including lesion resection with clear surgical margins and acceptable length of stay. We believe that endobronchial instillation of ICG and CT‐guided methylene blue injection for lesion localisation show promise as a technique to complement parenchymal sparing thoracic oncological surgery.
Estimating the effects of wind loss mitigation on home value
Authors: Awondo Sebastain , Hollans Harris , Powell Lawrence , Wade Chip 
Published: June 2023

AbstractWe empirically estimate the effects of windstorm loss mitigation features on the value of coastal homes using fixed‐effects and spatial regression hedonic models. We use housing data from the “Fortified Home” program, which prescribes and certifies windstorm resilience features for residential property. We test the extent to which Fortified construction and the location of a house relative to the coast act as mitigation complements or substitutes. We find that on average homebuyers located at median distance to the coast pay a 6%–7% premium for Fortified homes, which exceeds the typical cost of building or retrofitting houses to the Fortified standard. Fortified construction and distance of the house from the coast are mitigation substitutes. The premium is highest for homes nearest the coast. Our findings are robust under various specifications of spatial hedonic models.
Exosomes derived miR‐362 exacerbates pneumonia by increasing Interleukin‐6 via targeting VENTX
Authors: Zhang Dongqing , Pan Fei , Zhu Minjie , Li Na , Liu Mei 
Published: June 2023

AbstractPneumonia is a condition characterized by lung damage resulting from a robust immune response by the host. While the defense and immunity against bacterial lung infections have been extensively studied, little is known about the specific immune factors involved in the progression of bacterial pneumonia. To address this knowledge gap, our study aimed to compare normal lung tissues with pneumonia tissues using various techniques, including HE staining, RNA sequencing, RT‐PCR, and Elisa assay. Our analysis revealed a significant increase in the levels of interleukin‐6 (IL‐6) in pneumonia tissues compared to normal lung tissues. To further investigate the underlying mechanism, we extracted exosomes from both pneumonia and normal lung tissues using ultracentrifugation. The exosomes were then examined using electron microscopy, diameter analysis, and western blot assay. RNA sequencing of the exosomes revealed an upregulation of several microRNAs (miRNAs), with miR‐362 exhibiting the most significant change. This finding was confirmed through RT‐PCR analysis conducted on lung tissues and alveolar lavage fluid. To gain insights into the specific target genes of miR‐362, we employed bioinformatics analysis, which identified VENTX as a potential target gene. This finding was further validated through RT‐PCR, western blot, and luciferase assay. Our experimental evidence demonstrated that miR‐362 regulates VENTX expression, as evidenced by the use of miR‐362 mimics or inhibitors on lung cells. Furthermore, we discovered that exosomes derived from pneumonia tissues upregulate IL‐6 production through the miR‐362/VENTX axis. Importantly, the blocking of IL‐6 generation, which is facilitated by miR‐362 inhibitor and VENTX overexpression lentivirus, can be achieved by treating exosomes. Moreover, we conducted in vivo experiments using pneumonia models. Rats were treated with IL‐6, miR‐362 mimics, or VENTX knock‐down lentivirus. The results demonstrated a worse prognosis for rats treated with these factors, indicating their potential as prognostic markers. Taken together, our study suggests that exosomes facilitate IL‐6 generation by transferring miR‐362, thereby suppressing VENTX transcription. Consequently, the IL‐6/miR‐362/VENTX axis emerges as a promising therapeutic target for pneumonia.
Isotopes in Economic Geology, Metallogeny and Exploration—Future Challenges and Opportunities
Authors: Huston David L. , Gutzmer Jens 
Published: June 2023

AbstractAlthough the intent of this book is to provide readers with an overview on the current and past usage of isotopes in the broad disciplines of economic geology, metallogenesis and mineral exploration, some of the chapters highlight future challenges and opportunities for the use of both radiogenic and stable isotopes within these disciplines and more broadly. This concluding section identifies and then discusses how some of these challenges might be overcome and the opportunities that might be realized.
“To Pick Up the Unsaid, and Perhaps Unknown, Wishes”: Reimagining the “True Stories” of the Past in Evelyn Conlon’s Not the Same Sky
Authors: Caneda-Cabrera M. Teresa 
Published: June 2023

AbstractThis chapter approaches Evelyn Conlon’sNot the Same Skyas an imaginative retrieval of a silenced and untold episode of the Irish Famine and looks at the novel as a text that not only translates the past into the present (since it bestows visibility on an unspoken historical event) but also perceptively foregrounds connections between translation, mobility and memory. The chapter suggests thatNot the Same Skyfunctions itself as a “memory site” and, thus, becomes an astute reflection on the complexities attached to events and discourses concerned with the cultural reconstruction of knowledge. In this respect, the chapter argues that Conlon’s novel lends itself to be analysed as an inquiry into the concept of translation and the unsolved ethical dilemmas attached to the debate on voice and voicing which often accompany translational acts.
The Irish Short Story and the Aesthetics of Silence
Authors: D’hoker Elke 
Published: June 2023

AbstractThis chapter investigates the different ways in which the Irish short story can be considered an art of silence. Taking Joyce’sDublinersas an example, it first provides an overview of the strategies of silence used in the modern short story: ellipsis, eclipse and epiphany. While these strategies are a corollary of the short story’s brevity, they also reflect what Susan Sontag called the aesthetics of silence, modern art’s attempt to communicate the unsayable. The chapter then analyses how contemporary Irish short fiction writers, like Moore, O’Brien, Trevor, Kelly and Keegan, have used these strategies to explore silence both negatively—as the result of trauma, tyranny, taboo and secrets—and positively, as a mark of respect and communion—in their works.
Gestaltung qualitätsvollen Unterrichts
Authors: Marusic Claudia 
Published: June 2023

ZusammenfassungNachfolgend werden Merkmale von Unterrichtsqualität dargelegt, um damit einerseits darzustellen, hinsichtlich welcher Aspekte die Lehrpersonen gefordert werden, um einen guten, qualitätsvollen Unterricht durchzuführen. Andererseits soll der Kontext ausgeleuchtet werden, in welchem Unterrichtsstörungen potenziell auftreten bzw. wie Störungen durch einen qualitätsvoll gestalteten Unterricht verringert werden können. Betrachtet werden zwei systemische Rahmenmodelle und die generischen Basisdimensionen zur Erklärung von Unterrichtsqualität. Da die Basisdimension der effektiven Klassenführung eine wichtige Grundlage eines möglichst störungsfreien Unterrichts darstellt, wird diese Dimension in einem eigenen Kapitel beleuchtet. Schliesslich wird in Abschnitt 3.3 auf die Gestaltung von Unterricht in Settings für personalisiertes Lernen eingegangen, um dadurch diesen spezifischen Kontext für die Produktion sowie Wahrnehmung von und Umgang mit Unterrichtsstörungen zu betrachten. Dieses Kapitel schliesst mit einem Zwischenfazit.
Die Rolle impliziter Wissensstrukturen und Handlungsorientierungen für das professionelle Wahrnehmen und Handeln von Lehrpersonen
Authors: Marusic Claudia 
Published: June 2023

ZusammenfassungDie Anforderungen an das Handeln der Lehrperson sind komplex. Um guten Unterricht umzusetzen, sind facettenreiche, professionelle Kompetenzen notwendig. Kenntnisse über den Ablauf unterrichtlicher Wahrnehmungs- und Handlungsprozesse ermöglichen es Lehrpersonen ihre impliziten Handlungen im Unterricht wahrzunehmen und damit reflektierbar zu machen (Schweer et al., 2017). Im vorliegenden Kapitel wird – nach einer kurzen Einführung in den Diskurs zur Professionalität von Lehrpersonen – zuerst auf die Professionsstandards (Abschnitt 4.1.1) und auf die Dimensionen professioneller Handlungskompetenzen von Lehrpersonen (Abschnitt 4.1.2) eingegangen und damit die Voraussetzungen sowie Anforderungsbereiche an unterrichtliches Handeln näher betrachtet. Danach werden in Übereinstimmung mit dem Fokus dieser Arbeit auf die impliziten Wissensstrukturen bzw. Überzeugungen als Kompetenzfacetten unterschiedliche Zugänge zur Offenlegung impliziter Wissensstrukturen aufgegriffen, die dem Lehrer:innenhandeln zugrunde liegen, (Abschnitt 4.1.3). Abschnitt 4.1.4 schliesst an mit Ausführungen zum Begriff der Handlungsorientierungen, der für diese Arbeit zentral ist. Bevor Handlungen ausgeführt werden, bestimmen Wahrnehmungsprozesse, welche Handlungsbedarfe von den Wahrnehmenden überhaupt erkannt und als notwendig erachtet werden. In Abschnitt 4.1.5 wird deshalb der unterrichtliche Wahrnehmungsprozess von Lehrpersonen genauer beleuchtet. Abschliessend wird die Rolle von Reflexion zur Veränderbarkeit impliziter Wissensstrukturen thematisiert, da dies für die Veränderbarkeit von Umgangsformen mit Unterrichtsstörungen relevant ist (Abschnitt 4.1.6). Auch dieses Kapitel schliesst wiederum mit einem Zwischenfazit (4.2).
Forschungsdesign
Authors: Marusic Claudia 
Published: June 2023

ZusammenfassungNachfolgend wird deshalb das methodische Vorgehen dieser Arbeit nachvollziehbar dargestellt. Zuerst wird dafür auf die Stichprobe (Abschnitt 6.1) eingegangen, worauf die SUGUS-Studie und die perLen-Studie näher kommentiert werden (Abschnitt 6.2). Danach wird die Datenerhebung anhand des problemzentrierten Interviews dargelegt (Abschnitt 6.3). In einem weiteren Schritt wird das Auswertungsverfahren der Dokumentarischen Methode näher betrachtet, das für die Analysen der vorliegenden Arbeit angewendet wurde (Abschnitt 6.4) sowie die einzelnen Auswertungsschritte im Detail erläutert (6.5). Das Kapitel endet mit einem Zwischenfazit (6.6).
Darstellung der Ergebnisse
Authors: Marusic Claudia 
Published: June 2023

ZusammenfassungZuerst wird auf die Darstellung der Analysen ausgewählter Fälle eingegangen (Abschnitt 7.1), um anschliessend die sinngenetischen Typen darzulegen (Abschnitt 7.2). Die Korrespondenzanalyse wird in Abschnitt 7.3 vorgestellt. Anschliessend werden Kontextfaktoren zur Erklärung der sinngenetischen Typen vorgestellt (Abschnitt 7.4).
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
Authors: Sideli Lucia , Aas Monica , Quattrone Diego , La Barbera Daniele , La Cascia Caterina , Ferraro Laura , Alameda Luis , Velthorst Eva , Trotta Giulia , Tripoli Giada , Schimmenti Adriano , Fontana Andrea , Gayer-Anderson Charlotte , Stilo Simona , Seminerio Fabio , Sartorio Crocettarachele , Marrazzo Giovanna , Lasalvia Antonio , Tosato Sarah , Tarricone Ilaria , Berardi Domenico , D’Andrea Giuseppe ,   EU-GEI WP2 Group, Amoretti Silvia , Andreu-Bernabeu Álvaro , Baudin Grégoire , Beards Stephanie , Bonetto Chiara , Bonora Elena , Cabrera Bibiana , Carracedo Angel , Charpeaud Thomas , Costas Javier , Cristofalo Doriana , Cuadrado Pedro , Durán-Cutilla Manuel , Ferchiou Aziz , Fraguas David , Franke Nathalie , Frijda Flora , Garcia-Portilla Paz , González Peñas Javier , Hubbard Kathryn , Jamain Stéphane , Jiménez-López Estela , Leboyer Marion , Llorente Cloe , López Montoya Gonzalo , Lorente-Rovira Esther , M. Díaz-Caneja Covadonga , Marcelino Loureiro Camila , Matteis Mario , Messchaart Elles , Moltó Ma Dolores , Mezquida Gisela , Moreno Carmen , Muratori Roberto , Nacher Juan , Parellada Mara , Rapado-Castro Marta , Ruggeri Mirella , Richard Jean-Romain , Rodríguez Solano José Juan , Sáiz Pilar A. , Sánchez-Gutierrez Teresa , Sánchez Emilio , Schürhoff Franck , Seri Marco , Shuhama Rosana , Termorshuizen Fabian , Tronche Anne-Marie , van Dam Daniella , van der Ven Elsje , Arango Celso , Arrojo Manuel , Bernardo Miguel , Bobes Julio , Sanjuán Julio , Santos Jose Luis , Menezes Paulo Rossi , Del-Ben Cristina Marta , Jongsma Hannah E. , Jones Peter B. , Kirkbride James B. , Llorca Pierre-Michel , Tortelli Andrea , Pignon Baptiste , de Haan Lieuwe , Selten Jean-Paul , Van Os Jim , Rutten Bart P. , Bentall Richard , Di Forti Marta , Murray Robin M. , Morgan Craig , Fisher Helen L. 
Published: June 2023

AbstractThis study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Watermelons, Syringes, and Regulation: Instagram Marketing by Cosmetic Clinics in the UK and the Netherlands
Authors: Hermans Anne-Mette 
Published: June 2023

Abstract
Background
Cosmetic clinics use social media to inform and market to prospective patients. Evidence from social media posts by the UK and Dutch cosmetic clinics illustrates the precarious balance between professionalism and commercialism, and raises important questions for the regulation of these marketing communication efforts.

Methods
A random selection of Instagram posts by Dutch and the UK clinics which offer (non-) invasive cosmetic procedures were selected for a qualitative content analysis. The corpus of data comprised 395 posts by six Dutch and four UK clinics, published between January 2018 and July 2019. The method of analysis was inspired by previous qualitative studies into the marketing of cosmetic procedures and can be described as a (discursive) thematic analysis.

Results and Conclusions
The tension between the medical-professional and commercial nature of cosmetic procedures was evident in the Instagram posts by Dutch and UK clinics. Despite calls for ‘ethical’ marketing on social media, this study illustrates that marketing materials are not always in line with current advertising guidelines. Whereas advertising standards authorities have warned against the trivialization of cosmetic procedures, posts by clinics backgrounded the medical nature of procedures in favor of more commercial advertising appeals. Furthermore, the posts demonstrated little diversity in terms of models’ gender, ethnicity and body type, which reinforces narrow contemporary beauty ideals.

Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Genicular Artery Embolisation in Patients with Osteoarthritis of the Knee (GENESIS 2): Protocol for a Double-Blind Randomised Sham-Controlled Trial
Authors: Little Mark W. , Harrison Richard , MacGill Sarah , Speirs Archie , Briggs James H. , Tayton Edward , Davies Nev L. C. , Hausen Heike S. , McCann Claire , Levine Lisa L. , Sharma Ricky A. , Gibson Matthew 
Published: June 2023

AbstractKnee osteoarthritis is a leading cause of chronic disability and economic burden. In many patients who are not surgical candidates, existing treatment options are insufficient. Clinical evidence for a new treatment approach, genicular artery embolisation (GAE), is currently limited to single arm cohort, or small population randomised studies. This trial will investigate the use of a permanent embolic agent for embolisation of abnormal genicular arterial vasculature to reduce pain in patients with mild to moderate knee osteoarthritis. Up to 110 participants, 45 years or older, with knee pain for ≥ 3 months resistant to conservative treatment will be randomised (1:1) to GAE or a sham procedure. The treatment group will receive embolisation using 100-micron Embozene™ microspheres (Varian, a Siemens Healthineers Company) (investigational use for this indication in the UK), and the sham group will receive 0.9% saline in an otherwise identical procedure. Patients will be followed for 24 months. At 6 months, sham participants will be offered crossover to GAE. The primary endpoint is change of 4 Knee Injury and OA Outcome Score subscales (KOOS4) at 6 months post-randomisation. The study will also evaluate quality of life, health economics, imaging findings, and psychosocial pain outcomes. The primary manuscript will be submitted for publication after all participants complete 6 months of follow-up. The trial is expected to run for 3.5 years. Trial Registration: ClinicalTrials.gov, Identifier: NCT05423587.
Perturbation theory for evolution of cooperation on networks
Authors: Meng Lingqi , Masuda Naoki 
Published: June 2023

AbstractNetwork structure is a mechanism for promoting cooperation in social dilemma games. In the present study, we explore graph surgery, i.e., to slightly perturb the given network, towards a network that better fosters cooperation. To this end, we develop a perturbation theory to assess the change in the propensity of cooperation when we add or remove a single edge to/from the given network. Our perturbation theory is for a previously proposed random-walk-based theory that provides the threshold benefit-to-cost ratio,$$(b/c)^*$$(b/c)∗, which is the value of the benefit-to-cost ratio in the donation game above which the cooperator is more likely to fixate than in a control case, for any finite networks. We find that$$(b/c)^*$$(b/c)∗decreases when we remove a single edge in a majority of cases and that our perturbation theory captures at a reasonable accuracy which edge removal makes$$(b/c)^*$$(b/c)∗small to facilitate cooperation. In contrast,$$(b/c)^*$$(b/c)∗tends to increase when we add an edge, and the perturbation theory is not good at predicting the edge addition that changes$$(b/c)^*$$(b/c)∗by a large amount. Our perturbation theory significantly reduces the computational complexity for calculating the outcome of graph surgery.