bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aromatic-bridged and meso-meso-linked BF2-smaragdyrin dimers exhibit fast decays in polar solvents by symmetry-breaking charge transfer
Authors: Wen Lingbo , Cao Xian , Lee Seokwon , Xu Ling , Rao Yutao , Kang Seongsoo , Kim Dongho , Osuka Atsuhiro , Song Jianxin 
Published: February 2023

AbstractSymmetry-breaking charge transfer is one of the key process in photosynthetic reaction centers and specific artificial optoelectronic devices such as dye-sensitized solar cells. Here we report the synthesis of aromatic-bridged BF2-smaragdyrin dimers, meso-free BF2-smaragdyrin, and its meso-meso-linked BF2-smaragdyrin dimer. The decays of S1-states of these dimers are accelerated with an increase in solvent polarity and a decrease in the distance between the two BF2-smaragdyrin units, suggesting symmetry-breaking charge transfer. The fluorescence lifetimes of the dimers become shortened in polar solvents. However, ultrafast transient absorption spectroscopy do not detect charge-separated ion pairs. On the basis of these results, we conclude that the decays of the excited states of the BF2-smaragdyrin dimers are accelerated by solvation-induced symmetry-breaking charge transfer, depending on the degree of the electronic interaction between the smaragdryin units as a rare case for porphyrinoids. The degree of charge transfer is larger for dimers with larger electronic interactions.
Assessing Patients and Care Partner Ratings of Communication-Related Participation Restrictions: Insights From Degenerative Disease
Authors: Utianski Rene L. , Martin Peter R. , Duffy Joseph R. , Clark Heather M. , Stierwalt Julie A. G. , Botha Hugo , Ali Farwa , Whitwell Jennifer L. , Josephs Keith A. 
Published: February 2023

Purpose:

Prior studies have shown that communication-related participation restrictions in patients with degenerative disease do not always match clinician judgment or objective indices of symptom severity. Although there is a growing body of literature documenting that discrepancies between patients with dementia and their care partners' perception of participation restrictions exist, it is not known how care partner perceptions of
communication
participation restrictions specifically match or diverge from the patients' experiences, which may inform the use of care partner proxy in the context of degenerative diseases.

Method:
Thirty-eight patients with progressive neurologic conditions (progressive supranuclear palsy, corticobasal syndrome, and primary progressive aphasia or apraxia of speech) and, in most instances, focal cognitive-communication disorders were included. The patients and their accompanying care partners independently completed the Communicative Participation Item Bank, short form, a 10-question survey about communication participation restrictions in different contexts. Care partners were instructed to complete the form with their perception of the patient's experience. The difference between patient and care partner total scores were calculated and analyzed relative to clinical and demographic variables of interest.

Results:
Care partner ratings modestly tracked with patient experience and objective indices of symptom severity but did not exactly match patient ratings. The presence of aphasia increased, but did not fully account for, the likelihood of a discrepancy between care partner and patient ratings.

Conclusion:
Although careful consideration should be given prior to using care-partner report as a proxy for patient experience, it is worthwhile to include care partner ratings as a means of supporting conversations about differing perceptions, guiding joint intervention planning, and monitoring care-partner perceptions of change along with the implementation of supported conversation strategies.
No clinical difference at mid-term follow-up between TiN-coated versus uncoated cemented mobile-bearing total knee arthroplasty: a matched cohort study
Authors: Deroche Etienne , Batailler Cécile , Shatrov Jobe , Gunst Stanislas , Servien Elvire , Lustig Sébastien 
Published: February 2023

Introduction: Nitride-based ceramic coating was introduced into surgical implants to improve hardness, reduce abrasion, and decrease the risk of metal-induced adverse reactions, especially for patients with suspected or identified metal hypersensitivity. The study aimed to evaluate the effectiveness and safety of a titanium nitride (TiN) coated prosthesis with a mobile bearing design. Methods: This was a retrospective matched-cohort study from a single center, comparing clinical outcomes between patients receiving either a TiN-coated versus an uncoated cobalt-chromium-molybdenum (CoCrMo) prostheses for primary total knee replacement. Seventeen patients received the TiN prosthesis between 2015 and 2019. These were matched 1:2 with patients receiving uncoated mobile-bearing knee prostheses with the same design manufacturer. Results: Fourteen patients in the TiN group had complete 5-year follow-up data and were compared with 34 patients from the CoCrMo group. The Knee Society Score was 170.6 ± 28.0 (Function subscore 83.7 ± 17.5 and Knee subscore 86.9 ± 13.8) in the TiN group and 180.7 ± 49.4 (Function subscore 87.5 ± 14.3 and Knee subscore 93.2 ± 9.6) in CoCrMo group, with no statistically significant difference (p = 0.19). One patient underwent a revision for instability requiring the removal of the implant in the TiN group and none in the CoCrMo group. The survival rates were 92.9% (CI95% 77.3–100.0) and 100.0% in the TiN group and CoCrMo group respectively (p = 1.0). Discussion: TiN-coated TKA with mobile bearing resulted in satisfactory clinical outcomes, and a low revision rate, and there was no complication related to the coated implant. The use of TiN-coated prostheses in case of confirmed or suspected metal allergy provides satisfactory short-term clinic outcomes.
Pulmonalarterielle Hypertonie und kardiopulmonale Komorbidität
Authors: Grünig Ekkehard , Benjamin Nicola , Echampati Ishan , Xanthouli Panagiota 
Published: February 2023

ZusammenfassungIn den neuen Leitlinien für pulmonalarterielle Hypertonie (PAH, Gruppe 1) wird erstmals empfohlen, vor Therapiebeginn zwischen PAH-Patienten mit bzw. ohne kardiopulmonale Komorbiditäten zu
unterscheiden. Hintergrund hierfür ist, dass einerseits in den zulassungsrelevanten Therapiestudien Patienten mit Komorbiditäten unterrepräsentiert bzw. ausgeschlossen waren, andererseits
diese Gruppe aber bei Weitem den größten Anteil der PAH-Patienten in der klinischen Praxis stellen. Während Patienten mit Komorbiditäten von PAH-Medikamenten wie
Phosphodiesterase-5-Inhibitoren zumeist als Monotherapie profitieren, ist eine Therapie der Patienten mit einer pulmonalen Hypertonie (PH) bei Linksherz- (Gruppe 2) oder Lungenerkrankung
(Gruppe 3) mittels PAH-Medikamente nicht indiziert und kann z. T. sogar zu einer erhöhten Letalität führen. In diesem Artikel wird beschrieben, wie man PAH-Patienten mit Komorbiditäten von
PH-Patienten der Gruppe 2 und 3 differenzieren kann. Die Unterscheidung und Stellung der Therapieindikation ist dabei oft nicht einfach und sollte in einem PH-Zentrum vorgenommen werden.
Pulmonale Hypertonie – alte vs. neue Leitlinie Hämodynamische Definition und klinische Klassifikation – Was ändert sich 2022?
Authors: Heberling Melanie , Grünig Ekkehard , Kolditz Martin , Koschel Dirk , Halank Michael 
Published: February 2023

ZusammenfassungEnde August 2022 wurde die neue europäische Leitlinie (LL) zur Diagnose und Therapie der pulmonalen Hypertonie (PH) von der Europäischen Gesellschaft für Kardiologie (ESC) und der
Europäischen Gesellschaft für Pneumologie (ERS) gemeinsam publiziert. Eine wesentliche Neuerung der PH-LL ist die neue Definition der PH durch den mittleren pulmonalarteriellen Druck (mPAP)
von > 20 mmHg und einem pulmonalvaskulären Widerstand (PVR) auf > 2 Wood-Einheiten (WU) in Ruhe. Eine schwere PH bei Lungen- oder Linksherzerkrankung wird aktuell durch einen PVR
> 5 WU charakterisiert. Die Kriterien einer Belastungs-PH wurden neu definiert und wieder mit in die Leitlinie aufgenommen. Bei der klinischen Klassifikation wurde im Wesentlichen nur die
Gruppe der idiopathischen pulmonalarteriellen Hypertonie (IPAH) neu in die Subgruppen „Nonresponder“ und „Responder“ untergliedert sowie PAH-Patienten mit Merkmalen einer zusätzlichen
venösen/kapillären Veränderung (PVOD/PCH) wieder in die Gruppe 1 eingegliedert.
Realistic characteristics and driving mechanisms of pseudo-human settlements in Chinese cities
Authors: Yu Wenbo , Yang Jun , Wu Feng , He Baojie , Xue Bing , Wang Shaohua , Yu Huisheng , Xiao Xiangming , Xia Jianhong 
Published: February 2023

AbstractPseudo-human settlements (PHS) reflect the subjective wishes and needs of residents. An in-depth characterization of PHS aids in clarifying the actual development needs and future development directions of the city from the residents’ perspective. China is currently undergoing high-speed urbanization and advocates improving the quality of cities. It is particularly important to test the achievements of urbanization through PHS. This study quantitatively analyses spatiotemporal characteristics and the realistic driving mechanism of PHS in 286 Chinese cities through spatial autocorrelation analysis and geographic detectors. The results indicate that (1) the PHS level exhibited notable hierarchical characteristics and spatial differences (high in the eastern coastal regions and low in the western inland regions), with weak positive autocorrelation characteristics; (2) nighttime light index, per capital GRP, and population size are major drivers of heterogeneity of development level and functional structure of PHS; and (3) the functional structure followed an emergence-development-maturity-decline-extinction life cycle. Overall, the development of PHS must play a leading role in high-level areas, and urban decision-makers should clarify and adapt to local preferences of PHS and predict future changes. The findings of this study can help China and other countries promote realistic development by unveiling the characteristics of PHS.
Effect of the Gaussian distribution parameters of the electron beam generated at the target on the simulated x-ray dose
Authors: Assalmi Mustapha , Diaf EL Yamani 
Published: February 2023

Abstract
The purpose of this work was to investigate by Monte Carlo method the adjustment of photon beams delivered by the medical LINear ACcelerator (LINAC) Elekta Synergy MLCi2. This study presents an optimization of the Gaussian distribution parameters of the accelerated electrons before the target simulated by two Monte Carlo codes and for three beams. The photon (x-ray) beam is produced by the interaction of accelerated electrons with the LINAC target. The electrons are accelerated by a potential difference created between the anode and the cathode of the gun and directed towards the target. In the Monte Carlo simulation, it is necessary to setup the spectrum parameters of the generated electrons to simulate the x-ray dose distribution. In this study, we modeled the LINAC geometry for photon beams 18MV and 6MV in cases Flattened (FF) and Flattening-Filter-Free (FFF). The Monte Carlo simulations are based on G4Linac_MT and GATE codes. The results of the optimized configurations determined after more than 20 tests for each beam energy show a very good agreement with the experimental measurements for different irradiation fields for the depth (PDD) and lateral (Profile) dose distribution. In all Monte Carlo calculations performed in this study, the statistical uncertainty is less than 2%. The results were also in very good agreement in terms of γ-index analysis, for the 3%/3 mm and 2%/2 mm criteria.
Modeling resistance increase in a composite ink under cyclic loading
Authors: Li Q , Chung E , Antoniou A , Pierron O 
Published: February 2023

Abstract
The electrical performance of stretchable electronic inks degrades as they undergo cyclic deformation during use, posing a major challenge to their reliability. The experimental characterization of ink fatigue behavior can be a time-consuming process, and models allowing accurate resistance evolution and life estimates are needed. Here, a model is proposed for determining the electrical resistance evolution during cyclic loading of a screen-printed composite conductive ink. The model relies on two input specimen-characteristic curves, assumes a constant rate of normalized resistance increase for a given strain amplitude, and incorporates the effects of both mean strain and strain amplitude. The model predicts the normalized resistance evolution of a cyclic test with reasonable accuracy. The mean strain effects are secondary compared to strain amplitude, except for large strain amplitudes (>10%) and mean strains (>30%). A trace width effect is found for the fatigue behavior of 1 mm vs 2 mm wide specimens. The input specimen-characteristic curves are trace-width dependent, and the model predicts a decrease in N
f by a factor of up to 2 for the narrower trace width, in agreement with the experimental results. Two different methods are investigated to generate the rate of normalized resistance increase curves: uninterrupted fatigue tests (requiring ∼6–7 cyclic tests), and a single interrupted cyclic test (requiring only one specimen tested at progressively higher strain amplitude values). The results suggest that the initial decrease in normalized resistance rate only occurs for specimens with no prior loading. The minimum-rate curve is therefore recommended for more accurate fatigue estimates.
Electromagnetic simulation and microwave circuit approach of heat transport in superconducting qubits
Authors: Satrya Christoforus Dimas , Guthrie Andrew , Mäkinen Ilari K , Pekola Jukka P 
Published: February 2023

Abstract
The study of quantum heat transport in superconducting circuits is significant for further understanding the connection between quantum mechanics and thermodynamics, and for possible applications for quantum information. The first experimental realisations of devices demonstrating photonic heat transport mediated by a qubit have already been designed and measured. Motivated by the analysis of such experimental results, and for future experimental designs, we numerically evaluate the photonic heat transport of qubit-resonator devices in the linear circuit regime through electromagnetic simulations using Sonnet software, and compare with microwave circuit theory. We show that the method is a powerful tool to calculate heat transport and predict unwanted parasitic resonances and background.
Streamer and leader characterization in HFO1234ze(E) gas, in a divergent electric field
Authors: Soulié S , Bonifaci N , Lesaint O , Gentils F 
Published: February 2023

Abstract
Pre-breakdown phenomena in HFO1234ze-(E) gas, considered as a potential replacement of SF6 for medium voltage insulation, are studied in needle-plane electrode systems versus pressure (0.01 to 0.3 MPa) under positive impulse voltage. Measurements are also carried out in air and SF6 in the same conditions for comparison. At the lowest pressure in HFO, the propagation of fast streamers is observed. Above 0.03 MPa, breakdown is the consequence of the propagation of stepped leaders, with shapes and velocities nearly identical to those observed in SF6. Several leader features (minimum inception voltage, propagation length) show that leader formation and propagation is easier in HFO compared to SF6. In turn, this allow explaining why breakdown voltages in HFO are slightly lower than in SF6.
Neuromorphic deep spiking neural networks for seizure detection
Authors: Yang Yikai , Eshraghian Jason K , Duy Truong Nhan , Nikpour Armin , Kavehei Omid 
Published: February 2023

Abstract
The vast majority of studies that process and analyze neural signals are conducted on cloud computing resources, which is often necessary for the demanding requirements of deep neural network workloads. However, applications such as epileptic seizure detection stand to benefit from edge devices that can securely analyze sensitive medical data in a real-time and personalised manner. In this work, we propose a novel neuromorphic computing approach to seizure detection using a surrogate gradient-based deep spiking neural network (SNN), which consists of a novel spiking ConvLSTM unit. We have trained, validated, and rigorously tested the proposed SNN model across three publicly accessible datasets, including Boston Children’s Hospital–MIT (CHB-MIT) dataset from the U.S., and the Freiburg (FB) and EPILEPSIAE intracranial electroencephalogram datasets from Germany. The average leave-one-out cross-validation area under the curve score for FB, CHB-MIT and EPILEPSIAE datasets can reach 92.7

%

, 89.0

%

, and 81.1

%

, respectively, while the computational overhead and energy consumption are significantly reduced when compared to alternative state-of-the-art models, showing the potential for building an accurate hardware-friendly, low-power neuromorphic system. This is the first feasibility study using a deep SNN for seizure detection on several reliable public datasets.
Development of fuelling protocols for gaseous hydrogen vehicles: a key component for efficient and safe hydrogen mobility infrastructures
Authors: Xu Zhuang , Dong Wenping , Zhao Yuejing , Dong Hui , He Guangli 
Published: February 2023

Abstract
Large-scale applications of fuel-cell vehicles (FCVs) are of vital importance to reduce emissions of greenhouse gases in the transportation sector, especially in the heavy-duty and long-distance scenarios. Efficient fuelling for the on-board gaseous hydrogen cylinders of an FCV is essential to achieve a fuelling experience that is comparable to that of traditional fossil-fuel-powered vehicles. However, the heating effect during refuelling leads to potential safety issues when the hydrogen temperature in the cylinder exceeds 85°C. Therefore, fuelling protocols are critical to ensure the efficiency and safety of the hydrogen mobility infrastructure. In this paper, the fuelling protocols for FCV vans and buses with type III cylinders were developed and the pre-cooling temperatures were optimized to minimize the energy consumption. Their performance was demonstrated with a 35-MPa hydrogen fuelling station. We found that FCV vans and buses can be safely refuelled in 3 or 5 minutes at a minimum, respectively, demonstrating a fuelling experience that is similar to that of traditional vehicles.
Genome Report: Genome sequence of 1S1, a transformable and highly regenerable diploid potato for use as a model for gene editing and genetic engineering
Authors: Jayakody Thilani B , Hamilton John P , Jensen Jacob , Sikora Samantha , Wood Joshua C , Douches David S , Buell C Robin 
Published: February 2023

Abstract
Availability of readily transformable germplasm, as well as efficient pipelines for gene discovery are notable bottlenecks in the application of genome editing in potato. To study and introduce traits such as resistance against biotic and abiotic factors, tuber quality traits and self-fertility, model germplasm that is amenable to gene editing and regeneration is needed. Cultivated potato is a heterozygous autotetraploid and its genetic redundancy and complexity makes studying gene function challenging. Genome editing is simpler at the diploid level, with fewer allelic variants to consider. A readily transformable diploid potato would be further complemented by genomic resources that could aid in high throughput functional analysis. The heterozygous Solanum tuberosum Group Phureja clone 1S1 has a high regeneration rate, self-fertility, desirable tuber traits and is amenable to Agrobacterium-mediated transformation. We leveraged its amenability to Agrobacterium-mediated transformation to create a Cas9 constitutively expressing line for use in viral vector-based gene editing. To create a contiguous genome assembly, a homozygous doubled monoploid of 1S1 (DM1S1) was sequenced using 44 Gbp of long reads generated from Oxford Nanopore Technologies (ONT), yielding a 736 Mb assembly that encoded 31,145 protein-coding genes. The final assembly for DM1S1 represents a nearly complete genic space, shown by the presence of 99.6% of the genes in the Benchmarking Universal Single Copy Orthologs (BUSCO) set. Variant analysis with Illumina reads from 1S1 was used to deduce its alternate haplotype. These genetic and genomic resources provide a toolkit for applications of genome editing in both basic and applied research of potato.
Residual Central Nervous System Immune Activation Is Not Prevented by Antiretroviral Therapy Initiated During Early Chronic HIV Infection
Authors: Edén Arvid , Rydberg Frida , Yilmaz Aylin , Hagberg Lars , Gostner Johanna , Nilsson Staffan , Fuchs Dietmar , Gisslén Magnus 
Published: February 2023

AbstractBackgroundAntiretroviral therapy (ART) initiated during acute infection can potentially impact the central nervous system (CNS) reservoir, but the differential long-term effects of ART initiation during early or late chronic infection are unknown.MethodsWe included neuroasymptomatic people with human immunodeficiency virus (HIV) with suppressive ART initiated during chronic (&gt;1 year since transmission) HIV with archived cerebrospinal fluid (CSF) and serum samples after 1 and/or ≥3 years of ART from a cohort study. CSF and serum neopterin was measured using a commercial immunoassay (BRAHMS, Germany).ResultsIn total, 185 people with HIV (median, 79 [interquartile range, 55–128] months on ART) were included. A significant inverse correlation was found between CD4+ T-cell count and CSF neopterin only at baseline (r = −0.28, P = .002), but not after 1 (r = −0.026, P = .8) or ≥3 (r −0.063, P = .5) years of ART. No significant differences were seen in CSF or serum neopterin concentrations between different pretreatment CD4+ T-cell strata after 1 or ≥3 (median, 6.6) years of ART.ConclusionsIn people with HIV initiating ART during chronic infection, occurrence of residual CNS immune activation was not correlated with pretreatment immune status, even when treatment was initiated at high CD4+ T-cell counts, suggesting that the CNS reservoir, once established, is not differentially affected by the timing of ART initiation during chronic infection.