bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of 18F-labeled PSMA PET/CT in patients with biochemical recurrence of prostate cancer: a systematic review and meta-analysis
Authors: Yang Yuan-Yuan , Liu Zhi-Mou , Peng Ru-Chen 
Published: August 2023

Background After initial treatment of prostate cancer, increases in prostate-specific antigen (PSA) levels commonly signify potential relapse or metastasis. 18F-labeled prostate-specific membrane antigen (PSMA) is considered a promising treatment due to its favorable physical properties. Purpose To investigate the diagnostic value of 18F-PSMA PET/CT for the recurrence and/or metastasis of biochemical recurrence of prostate cancer (BRPca). Material and Methods A comprehensive literature search was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library databases. Combined sensitivity and specificity values for the use of 18F-PSMA PET/CT in patients with BRPca were obtained. The quality of the studies was tested using the Diagnostic Accuracy Research Quality Assessment tool. Meta-analysis was performed using STATA 15 software, and heterogeneity was subsequently tested. Results A total of 16 studies (1162 patients) were enrolled and had significant heterogeneity. The pooled sensitivity, specificity, and AUC values for 18F-PSMA PET/CT in the diagnosis of prostate recurrence and/or metastasis were 0.93 (0.89–0.95), 0.94 (0.85–0.98), and 0.96 (0,94–0.98), respectively. Meta-regression analyses showed that the sources of heterogeneity did not relate to ligands, study designs, or participants. The pooled sensitivity and specificity values of 18F-DCFPyL PET/CT were 0.90 (0.85–0.94) and 0.89 (0.85–0.93), respectively. The pooled sensitivity and specificity values of 18F-PSMA-1007 PET/CT were 0.89 (0.85–0.93) and 0.93 (0.70–0.99), respectively. The per-patient pooled sensitivity and specificity values were 0.92 (0.86–0.96) and 0.83 (0.41–0.97), respectively. The per-lesion pooled sensitivity and specificity values were 0.91 (0.86–0.94) and 0.91 (0.86–0.94), respectively. Conclusion According to our meta-analysis, 18F-PSMA PET/CT has the potential to be critical for the diagnosis of recurrence and/or metastasis in patients with BRPca.
On investigation of flexural, morphological, and shape memory properties for 3D printed PLA-PVDF NFs-PLA interleave composite structures for smart gripper applications
Authors: Thakur Vishal , Singh Rupinder , Kumar Ranvijay 
Published: August 2023

In the present study, the flexural, morphological, and shape memory properties of polylactic acid (PLA) matrix sandwiched with polyvinylidene difluoride (PVDF) Nanofibers (NFs) interleave composite structures have been investigated for applications of 4D printing such as smart grippers, and smart actuators. Firstly, an electrospinning process was carried out to form a PVDF NFs mat (thickness: 0.10–0.20 mm) under a flow rate of 3 µL/sec, an applied voltage of 12 kV, and a TCD of 100 mm. Further, the PVDF NFs mat was deposited in between the PLA layers, primed through fused filament fabrication (FFF) based 3D printing to manufacture the PLA-PVDF NFs-PLA based structures. In the next stage, the flexural properties were investigated for manufactured composite structures. The results highlight that the flexural strength of the composites was enhanced by 6.47% as compared to PLA. Results of the study are supported by a scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), V-I, V-R, and shape memory analysis. The finding of the study suggests that composite structures primed by higher mat thickness and zig-zag infill pattern have resulted in higher electrical resistance and better shape memory effect. However, increasing the voltage in the composite structure having higher mat thickness with a zig-zag fill pattern has resulted in a higher resistance drop.
The effect of flipped-jigsaw learning models on ethical decision-making
Authors: Ziyai Nasibe Yağmur , Bozkurt Ramazan , Kilickiran Hatice , Dogu Ozlem 
Published: August 2023

Background Ethical decision-making education in nursing can be taught effectively by combining different teaching models that support the visualisation of taught concepts and integrating theory into practice. Objectives The study aims to examine the effect of flipped and jigsaw learning models on ethical decision-making and ethical sensitivity in nursing. Research design We used a nested mixed design. A pretest-posttest single-group quasi-experimental design was used in the quantitative part, and a case study method was used in the qualitative part. Participants and research context This study was conducted in fall semester with second-year nursing students who studied an ethics course for the first time, using two different collaborative learning models. In the quantitative part, ethical dilemma and ethical sensitivity scales were made as pre-test with 117 and post-test with 128 students. In the qualitative part, a semi-structured three focus group interviews was conducted with 16 students. Ethical considerations After obtaining the approval of the University’s ethics committee, the study was carried out after obtaining participants’ informed written and verbal consent. Findings Students’ perspectives changed positively after training. This was related to six cases in section A of the Ethical Dilemma Scale. In part B, Practical Consideration (PC) and Principled Thinking (PT) mean scores were similar, showing no significant difference. For Familiarity in section C, it was determined that 68.4% of students in the pre-test and 77.3% in the post-test were familiar with similar dilemmas. The ethical sensitivity scale’s total scores were in a similar range. In the qualitative stage, ethical decision-making, ethical sensitivity, ethical dilemma and the improvement process were obtained as a theme. Conclusions There was an increase in the level of ethical sensitivity and familiarity with ethical dilemmas of nursing students after education. Flipped and jigsaw learning models can be used for nursing ethics courses.
Decision tree-based data mining approach for the evaluation of survival in primary malignant bone tumors: A surveillance, epidemiology and end results database study
Authors: Yapar Dilek , Yapar Aliekber , Tokgöz Mehmet Ali , Bilge Uğur 
Published: August 2023

Purpose This study aimed to conduct a large-scale population-based study to understand the epidemiological characteristics of Primary Malignant Bone Tumors (PMBTs) and determine the prognostic factors by concurrently using the classical statistical method and data mining methods. Methods Patients included in this study were extracted from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) database: “Incidence-SEER Research Data, 18 Registries, Nov 2020 Sub”. Patients with unclassified and incomplete information were excluded. This search algorithm resulted in a dataset comprising 6234 cases. Survival analyses were performed with Kaplan-Meier curves and the Log-rank test. Multivariate Cox regression analysis determined the independent prognostic factors of PMBT. A decision tree-based data mining technique was used in this study to confirm the prognostic factors. Results 5-years survival rate was 63.6% and 10-years survival rate was 55.3% in the patients with PMBT. Sex, age, median household income, histology, primary site, grade, stage, metastasis, and the total number of malignant tumors were determined as independent risk factors associated with overall survival (OS) in the multivariate COX regression analysis. The prognostic factors resulting in five terminal nodes in the decision tree (DT) included stage, age, and grade. The stage was the most important determining factor for vital status. The terminal node with the shortest number of surviving patients included 801 (72.3%) deaths in 1102 patients with distant stage, and hazard ratio was calculated as 5.4 (95% CI: 4.9–5.9; p < .001). These patients had a median survival of only 17 months. Conclusions Rules extracted from DTs provide information about risk factors in specific patient groups and can be used by clinicians making decisions on individual patients. We recommend using DTs in combination with COX regression analysis to determine risk factors and the effect of these factors on survival.
Botulinum Toxin to Improve Scar Quality in Cleft Lip Repair: A Systematic Review
Authors: Martinez Paul F. , Rogers Ashley E. , Mantilla-Rivas Esperanza , Hughes Helena , Melo Leal Daniela , Rana Md Sohel , Manrique Monica , Rogers Gary F. , Oh Albert K. 
Published: August 2023

Objective Cleft lip repair (CLR) can be complicated by hypertrophic scar or keloid. Botulinum toxin type A (BTA) may improve postoperative scarring by reducing muscle tension and cytokine activity at the scar site. This systematic review analyzes the available evidence regarding the effect of BTA on scar quality after CLR. Design The search was conducted in 6 different databases in accordance with PRISMA guidelines (PubMed, Scielo, Embase, Scopus, Web of Science, and Cochrane) using “botulinum toxin” and “cleft lip” as keywords. Setting Academic hospital Patients Exclusive to patients who underwent CLR and BTA injection Outcome measures Mean visual analog scores (VAS), mean Vancouver scar scale (VSS), scar width, and BTA or CLR-related complications. Results Five studies for a total of 216 patients met inclusion criteria. Four studies reported on primary CLR during infancy while 1 study recruited older patients seeking revision. All patients had BTA (range: 1-2 units/kg) injected in the orbicularis oris muscle. One study documented BTA injections in additional perioral muscles. All 4 studies that measured scar width and had a saline control arm found a significant decrease in width with BTA injection. Improvement of VAS and VSS with BTA was reported in 3 of 5 studies and 2 of 5 studies, respectively. There were no reports of complications associated with BTA or CLR. Conclusion The existing studies support the use of BTA injection to improve scar quality following CLR with low concern for complication. Further investigations with a greater number of patients are necessary.
Thirty Years of Service Failure and Recovery Research: Thematic Development and Future Research Opportunities From a Social Network Perspective
Authors: Liu Dong , Zhao Yanhui , Wang Guocai , Schrock Wyatt A. , Voorhees Clay M. 
Published: August 2023

Service failure and recovery (SFR) is a well-established area of research that has made considerable progress over the past 30 years. In this study, we used a combination of text mining, co-word analysis, and social network analysis (SNA) to explore the relationships among keywords in SFR research. We analyzed a dataset of 533 SFR articles published between 1990 and 2020, extracting the most frequently used keywords using text-mining techniques. These keywords were then subjected to co-word analysis and SNA to understand the development of themes and topics in SFR research. By examining changes in network centrality measures, we gained insights into the evolution of research in this field. Furthermore, by identifying gaps or disconnections in the keyword networks, we identified future research opportunities related to the impact of service recovery strategies on customer reactions, employee reactions, and firm outcomes, as well as the relationship between customer and employee responses.
Understanding the barriers to blood pressure assessment in cats
Authors: Caney Sarah MA , Page Su , Gunn-Moore Danièlle A 
Published: August 2023

Objectives A questionnaire was designed to survey veterinarians and veterinary nurses/technicians on blood pressure (BP) assessment in cats, including ocular examination, encompassing current methodology, indications, uptake and barriers. Methods An online questionnaire was produced and promoted to more than 2000 veterinary professionals, of whom 545 answered all questions and 85 answered most questions. Results Of the participants, 572 (90.8%) were based in the UK and almost all (n = 613, 97.3%) had access to a BP monitor. Of those that had a monitor, most (n = 550, 88.4%) participants had access to a Doppler monitor; 367 (59.0%) participants had access to multiparameter monitors; fewer (n = 202, 32.5%) had access to oscillometric BP monitors. Where applicable, Doppler monitors were most commonly chosen for conscious cat measurements (n = 337, 72.2%) due to the greater ‘trust’ and ‘reliability’ of these compared with oscillometric machines. Conscious BP measurement typically involved two members of staff (n = 391, 62.9%). Only 156 (29.1%) participants recommended BP assessment at least several times a week in their interactions with cat owners. BP assessment was routinely recommended in cats with ocular target organ damage (n = 365, 87.7%), chronic kidney disease (n = 346, 78.6%), proteinuria (n = 255, 63.0%) and hyperthyroidism (n = 266, 60.9%). Common equipment-related barriers included ‘cuff frustration’ and difficulties hearing the pulse signal for Doppler users (72.2% and 71.6%, respectively), and oscillometric machines failing to give a reading at least some of the time (52.8%). Situational hypertension concerns affected many (n = 507, 92.0%), as did lack of time to do the procedure (n = 402, 73.0%). Significant owner barriers included difficulties persuading the owner to bring their cat in for BP checks (n = 475, 86.2%) and concerns over costs (n = 445, 80.8%). Most participants had access to a direct ophthalmoscope (n = 527, 96.5%); however, 399 (73.1%) reported that they struggled to interpret ocular findings. Conclusions and relevance Significant barriers exist to successful BP assessment in cats. Education and support of clinics should focus on improving confidence with equipment and eye examination.
Long-term follow-up of cats in complete remission after treatment of feline infectious peritonitis with oral GS-441524
Authors: Zwicklbauer Katharina , Krentz Daniela , Bergmann Michèle , Felten Sandra , Dorsch Roswitha , Fischer Andrea , Hofmann-Lehmann Regina , Meli Marina L , Spiri Andrea M , Alberer Martin , Kolberg Laura , Matiasek Kaspar , Zablotski Yury , von Both Ulrich , Hartmann Katrin 
Published: August 2023

Objectives Feline infectious peritonitis (FIP), a common disease in cats caused by feline coronavirus (FCoV), is usually fatal once clinical signs appear. Successful treatment of FIP with oral GS-441524 for 84 days was demonstrated recently by this research group. The aim of this study was to evaluate the long-term outcome in these cats. Methods A total of 18 successfully treated cats were followed for up to 1 year after treatment initiation (9 months after completion of the antiviral treatment). Follow-up examinations were performed at 12-week intervals, including physical examination, haematology, serum biochemistry, abdominal and thoracic ultrasound, FCoV ribonucleic acid (RNA) loads in blood and faeces by reverse transciptase-quantitative PCR and anti-FCoV antibody titres by indirect immunofluorescence assay. Results Follow-up data were available from 18 cats in week 24, from 15 cats in week 36 and from 14 cats in week 48 (after the start of treatment), respectively. Laboratory parameters remained stable after the end of the treatment, with undetectable blood viral loads (in all but one cat on one occasion). Recurrence of faecal FCoV shedding was detected in five cats. In four cats, an intermediate short-term rise in anti-FCoV antibody titres was detected. In total, 12 cats showed abdominal lymphadenomegaly during the follow-up period; four of them continuously during the treatment and follow-up period. Two cats developed mild neurological signs, compatible with feline hyperaesthesia syndrome, in weeks 36 and 48, respectively; however, FCoV RNA remained undetectable in blood and faeces, and no increase in anti-FCoV antibody titres was observed in these two cats, and the signs resolved. Conclusions and relevance Treatment with GS-441524 proved to be effective against FIP in both the short term as well as the long term, with no confirmed relapse during the 1-year follow-up period. Whether delayed neurological signs could be a long-term adverse effect of the treatment or associated with a ‘long FIP syndrome’ needs to be further evaluated.
Feline chronic gingivostomatitis: current concepts in clinical management
Authors: Soltero-Rivera Maria , Goldschmidt Stephanie , Arzi Boaz 
Published: August 2023

Practical relevance: Feline chronic gingivostomatitis (FCGS) is a debilitating disease for cats and a challenge for veterinarians and cat caregivers alike. Recent literature indicates that the disease is immune-mediated in nature and likely associated with a chronic viral infection in patients with higher alpha diversity of their subgingival microbiome. The immune-mediated nature of FCGS includes both local as well as systemic effects, and the transcriptomic analysis of affected patients supports these findings. Treatment options: Localized therapy in the form of surgical extraction of all, or nearly all, teeth continues to be the mainstay of treatment. For cats that do not respond to surgical management, medical management, in the form of immunosuppressive or immunomodulatory therapy, remains an option. Analgesia is of fundamental importance. Immunomodulation utilizing mesenchymal stromal cell therapy provides an alternative treatment avenue for refractory patients and likely targets the chronic viral infection present in this disease. The potential for treatment stratification and use of novel systemic treatment options may be revealed as the molecular pathways involved in this disease are better described. Aims: This review outlines current and emerging concepts linking available science pertaining to FCGS and clinical management of the disease. Evidence base: The article draws on the best evidence base at this juncture and is also driven by the authors’ collective experience of working on the disease for over a decade.
Non-cuffed central venous catheter for unplanned and urgent start haemodialysis in chronic kidney disease: A multi-centre experience from India
Authors: Sathiavageesan Subrahmanian , Swaminathan Balamurugan , Myvizhiselvi Murugan , Ramakrishnan Gopalakrishnan , Elumalai Ramprasad 
Published: August 2023

Background: Central Venous Catheter (CVC) is indispensable to unplanned and urgent start haemodialysis in chronic kidney disease (CKD). While cuffed CVC is preferred to non-cuffed CVC for urgent start haemodialysis, patient’s clinical condition might warrant immediate insertion of non-cuffed CVC. In the resource poor setting, non-cuffed CVCs might have to be retained longer than guideline recommended limit of 2 weeks. In this multi-centre retrospective observational study, the real-world survival of non-cuffed CVC was assessed among CKD patients who initiated dialysis urgently. Methods: CVC survival was assessed by Kaplan-Meier survival estimate. Predictors of premature CVC loss were assessed using multi-level multi-variate Cox frailty model wherein, each centre was provided with a random intercept to account for within-centre correlation of practice patterns. Results: Among 433 non-cuffed CVCs, there were 393 removals out of which 80% were elective and 20% were premature. The median CVC survival was 37 days (95% CI: 35–41). The rate of premature CVC removal was 4.5/1000 CVC-days (95% CI: 3.6–5.6). Mechanical complications followed by central line associated blood stream infection (CLABSI) were the most common reasons for premature removal. Rate of CLABSI was 1.7/1000 CVC-days (95% CI: 1.2–2.5). Diabetic CKD significantly increased the hazard of premature CVC removal (HR 1.91, 95% CI: 1.01–3.63, p = 0.04) while right internal-jugular location decreased the hazard (HR 0.22, 95% CI: 0.13–0.38, p < 0.001). Conclusion: Prolonged retention of non-cuffed CVC (median 37 days) is common in resource-poor setting. It is worrisome and calls for pre-emptive access creation.
Pathways to care for people with dementia in India: An exploratory study using case vignettes
Authors: Thomas Priya Treesa , Rajagopalan Jayeeta , Hurzuk Saadiya , Ramasamy Narendhar , Pattabiraman Meera , De Poli Chiara , Lorenz-Dant Klara , Comas-Herrera Adelina , Alladi Suvarna 
Published: August 2023

Background Limited evidence exists on how people living with dementia and their family/unpaid carers navigate care and support in India. Aim This study used case vignettes to illustrate likely pathways to care for dementia, from receiving a diagnosis to long-term support, in India and to highlight gaps and challenges associated with current care provision for persons living with dementia. Methods As part of the Strengthening Responses to Dementia in Developing Countries (STRiDE) project, and to contribute to an analysis of dementia care policies and systems in India, case vignettes were used to illustrate the diverse situations that people with dementia and their families may experience when seeking care in the Indian context. Eight hypothetical, but realistic cases of people with dementia were created by a multi-disciplinary team with experience in dementia care in India, to map out the likely care journeys of each case. Results Investigating eight diverse care trajectories of people living with dementia highlighted important patterns relevant to the Indian context. We identified delays in dementia diagnosis to be attributed to low awareness of dementia among the general public and medical professionals in addition to a critical shortage of specialist services involved in facilitating dementia diagnosis. Post-diagnosis, support was recognized as limited and associated with considerable out-of-pocket (OOP) costs. Families primarily provide long-term care for people with dementia till end of life. Conclusions and Recommendations Several steps need to be taken in order to improve dementia care in India. Increasing dementia awareness among both medical professionals and general public is essential. Shortages in dementia specialists can be addressed in part through appropriate task shifting. Lastly, more research is needed to develop evidence-based community interventions to support informal care provision for persons with dementia in India.
Vaping—Know the Truth: Evaluation of an Online Vaping Prevention Curriculum
Authors: Hair Elizabeth C. , Tulsiani Shreya , Aseltine Madeleine , Do Elizabeth K. , Lien Rebecca , Zapp Daniel , Green Molly , Vallone Donna 
Published: August 2023

Background Unacceptably high levels of e-cigarette use among youth paired with growing research about the dangers of vaping demonstrate a critical need to develop interventions that educate young people to reject e-cigarette use and promote cessation for current users. Vaping: Know the Truth (VKT) is a free digital learning experience prioritizing middle and high school students that aims to improve students’ knowledge about the dangers of using e-cigarettes and provide quitting resources for those who already vape. The current study was designed to evaluate whether students receiving the curriculum increased knowledge of the dangers of vaping. Methods The outcome measures were calculated as the change in the number of correct responses from the pre- to post-module assessments among middle and high school students who completed four modules of the VKT curriculum ( N = 103,522). Linear regression was performed to determine the association between the student’s pre-module assessment score and the knowledge change score after completion of the four modules. Results Students’ e-cigarette knowledge significantly improved by an average of 3.24 points ( SD = 3.54), following implementation of the VKT curriculum. This indicates that participants answered more than 3 additional questions correctly, on average, after the intervention. Conclusion Findings demonstrate that the Vaping: Know the Truth curriculum is an effective resource for increasing knowledge among youth about the harms associated with e-cigarette use. Further research is needed to evaluate whether the intervention is associated with behavioral outcomes over time.