bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter propensity score-matched analysis of lymphadenectomy in N1-positve lung cancer
Authors: Handa Yoshinori , Tsutani Yasuhiro , Mimae Takahiro , Miyata Yoshihiro , Ito Hiroyuki , Shimada Yoshihisa , Nakayama Haruhiko , Ikeda Norihiko , Okada Morihito 
Published: August 2023

Abstract

Objectives
Selective mediastinal lymph node dissection based on lobe-specific metastases is widely recognized in daily practice. However, the significance of mediastinal lymph node dissection for N1-positive tumors has not been elucidated.

Methods
We retrospectively reviewed 359 patients with N1-positive lung cancer who underwent lobectomy with systematic mediastinal lymph node dissection (systematic lymph node dissection) (n = 150) and lobe-specific mediastinal lymph node dissection (lobe-specific lymph node dissection) (n = 209). The operative and postoperative results and their propensity score-matched pairs were compared. The factors affecting survival were assessed using competing risk and multivariable analyses.

Results
The cumulative incidence of recurrence and the cumulative incidence of cancer-specific death were not significantly different between systematic and lobe-specific lymph node dissection in entire cohort. In the propensity score-matched cohort (83 pairs), systematic lymph node dissection tended to detect N2 lymph node metastasis more frequently (55.4 vs. 41%, P = 0.087). Eleven patients (13.2%) in the systematic lymph node dissection group had a metastatic N2 lymph node ‘in the systematic lymph node dissection field’ that lobe-specific lymph node dissection did not dissect. The oncological outcomes between patients undergoing systematic lymph node dissection (5-year cumulative incidence of recurrence, 62.1%; 5-year cumulative incidence of cancer-specific death, 27.9%) and lobe-specific lymph node dissection (5-year cumulative incidence of recurrence, 60.1%; 5-year cumulative incidence of cancer-specific death, 23.3%) were similar. The propensity score-adjusted multivariable analysis for cumulative incidence of recurrence revealed that the prognosis associated with systematic lymph node dissection was comparable with the prognosis with lobe-specific lymph node dissection (hazard ratio, 1.17; 95% confidence interval, 0.82–1.67; P = 0.37).

Conclusions
The extent of lymph node dissection can affect accurate pathological staging; however, it was not associated with survival outcome in the treatment of N1-positive lung cancer.
High Physical Exposure During Female Recruits’ Basic Military Training in Sweden—A Descriptive Study
Authors: Kierkegaard Marie , Tegern Matthias , Halvarsson Alexandra , Broman Lisbet , Larsson Helena 
Published: August 2023

ABSTRACT

Introduction
There is a knowledge gap concerning the occurrence of physical complaints/injuries, i.e., musculoskeletal disorders (MSD), among Swedish women who undergo basic military training (BMT). The aims were to describe prevalence and factors related to MSD and explore physical exposure and performance in Swedish female recruits during BMT.

Materials and Methods
A total of 144 females (mean age 22 years) who underwent BMT in 2016 participated in this cross-sectional study. Data regarding self-reported MSD, physical performance, physical activity and exercise, motivation and mental and physical preparation, and physical exposure during BMT and perceived health were collected at the end of BMT through the Musculoskeletal Screening Protocol questionnaire. Additional data on muscle strength were retrieved from IsoKai isokinetic lift tests. Descriptive and analytic (paired samples t-test and logistic binary regression) statistics were used.

Results
The prevalence of MSD was high, with 33% (n = 48) reporting MSD before BMT, 78% (n = 113) during, and 50% (n = 72) at the end of BMT. Knee and upper back were the most frequently reported MSD locations. Forty-four (30%) participants felt insufficiently physically prepared for BMT. The physical exposure was high with loaded marches/runs and carrying heavy loads as the most demanding tasks. The longest walking distance was reportedly 55 km, and the reported maximum load was 50 kg. Forty-five participants (31%) had carried a load representing over 50% of their body weight. Most participants reported good to excellent health at the end of BMT. There was a small (8 N) but significant (P = 0.045) increase in mean force over time. Two variables, MSD before BMT (odds ratio 2.24, P = 0.03) and being physically unprepared (odds ratio 3.03, P &lt; 0.01), were associated with MSD at the end of BMT.

Conclusion
This study showed that the prevalence of MSD in Swedish female recruits was high before, during, and at the end of BMT, with knee and upper back as the most frequent locations. Although the physical exposure during BMT was occasionally high, self-rated health was mainly perceived as good to excellent at the end of BMT. Previous MSD and being physically unprepared were related to MSD at the end of BMT. These important and relevant findings indicate the necessity for implementing interventions to increase physical fitness and treat MSD at the beginning of BMT.
Adversarial inference: predictive minds in the attention economy
Authors: Bruineberg Jelle 
Published: August 2023

AbstractWhat is it about our current digital technologies that seemingly makes it difficult for users to attend to what matters to them? According to the dominant narrative in the literature on the “attention economy,” a user’s lack of attention is due to the large amounts of information available in their everyday environments. I will argue that information-abundance fails to account for some of the central manifestations of distraction, such as sudden urges to check a particular information-source in the absence of perceptual information. I will use active inference, and in particular models of action selection based on the minimization of expected free energy, to develop an alternative answer to the question about what makes it difficult to attend. Besides obvious adversarial forms of inference, in which algorithms build up models of users in order to keep them scrolling, I will show that active inference provides the tools to identify a number of problematic structural features of current digital technologies: they contain limitless sources of novelty, they can be navigated by very simple and effortless motor movements, and they offer their action possibilities everywhere and anytime independent of place or context. Moreover, recent models of motivated control show an intricate interplay between motivation and control that can explain sudden transitions in motivational state and the consequent alteration of the salience of actions. I conclude, therefore, that the challenges users encounter when engaging with digital technologies are less about information overload or inviting content, but more about the continuous availability of easily available possibilities for action.
Primary clear cell adenocarcinoma of the vagina not associated with diethylstilbestrol metastasizing to the lung: a case report
Authors: Benlghazi Abdelhamid , Belouad Moad , Messaoudi Hamza , Benali Saad , Aitbouhou Rachid , Fatima El Mangoub , Elhassani Mly Mehdi , Kouach Jaouad 
Published: August 2023

Abstract
Primary clear cell carcinoma of the vagina (PCCAV) is a rare form of vaginal cancer that typically affects young women with a history of prenatal exposure to DES. However, data on non-DES PCCAV cases are limited. This report describes a case of PCCAV in a 47-year-old patient who presented with post-coital bleeding and was diagnosed with clear cell adenocarcinoma via biopsy and MRI. The patient had no history of DES exposure and further testing showed no signs of metastasis, leading to surgery and chemotherapy. Four years later, the patient presented with dyspnea, and a chest CT scan revealed a lung nodule, later confirmed to be a metastasis of clear cell adenocarcinoma from the vaginal cancer. The patient passed away a month later due to complications from COVID-19.
Late distant recurrence of endometrial cancer in the lung after 5 years of radical surgery: a case report
Authors: Charii Hajar , Boudouh Asmae , Hayoune Amine , Thouil Afaf , Kouismi Hatim 
Published: August 2023

Abstract
Most endometrial cancer recurrences are seen within 3 years of radical treatment and are associated with various prognostic factors (tumor size, stage, grading, histotype…). Late relapses are considered rare. In this report, we present a case of a patient who was treated for endometrial adenocarcinoma. She underwent total resection and received four cycles of first-line adjuvant chemoradiation therapy using a combination of platinum salts and taxane. A total of 58 months later, the patient presented with chronic cough, and hemoptysis. A computed tomography scan revealed the presence of lung nodules suggestive of metastases. Biopsies were performed, showed infiltration of the bronchial mucosa by a poorly differentiated carcinoma of an endometrial origin. Our patient received two cycles of palliative chemotherapy but was lost to follow-up and eventually died. Imaging after hemoptysis revealed disease progression. Endometrial carcinoma patients treated with radical surgery (R0) can relapse after years of free disease. Thus, recommended: closer follow-up, clinical examination, symptom-based imaging.
The Indian Muslim Salariat and the Moral and Political Economies of Usury Laws in Colonial India, 1855–1914
Authors: O’Sullivan Michael 
Published: August 2023

Abstract
This article examines the long-term response of the Indian Muslim salariat to the lifting of usury laws in British India in 1855. The salariat were a group of urban professionals and landed gentry in north India who emerged after the uprising of 1857. They espoused a self-conscious brand of Islamic modernism, a central feature of which was a reinterpretation of Islamic traditions pertaining to ‘rent on money’ (interest/usury). Hitherto, Islamic legal rules authorizing interest/usury transactions had been context-dependent, but, motivated by the colonial state’s abrogation of usury caps and a critique of prevailing Islamic legal norms, the salariat articulated a context-free interpretation of interest/usury in which the two were made distinct. Henceforth, interest transactions among Muslims were acceptable, but ‘usurious’ moneylending, conflated with ‘Hindu’ moneylending, was condemned. This pro-interest, anti-usury programme frequently fused Islamic exegesis with readings from European political economy. In turn, the salariat crafted a vernacular political-cum-moral economy that they sought to propagate among the Muslim masses. Nevertheless, by 1914 the salariat had largely disavowed this programme, convinced that the colonial state’s revocation of usury laws had produced a Hindu–Muslim wealth gap. Now a new conception of an ‘Islamic’ economy, in which all interest was anathema, materialized.
Rational quality and cost of critical care systems are more important than individual considerations: a view from India
Authors: Dasgupta Sugata , Chandra Atanu 
Published: August 2023

Abstract
Critical or Intensive Care Units (CCU/ICUs) play a crucial role in treating critically ill patients, but they contribute significantly to healthcare costs. In India and many other resource-limited countries, private ICU treatment is largely unaffordable for the poor and even a section of the middle class, who are not substantially insured. It is essential for all stakeholders involved in critical care to prioritize quality and cost-effectiveness. To ensure quality assurance, legally binding quality standards must be developed collaboratively by the government, professional bodies, hospital administrators, and domain experts. Regulatory benchmarks relevant to different types of ICUs can enforce adherence and transparency. Telemedicine, referral systems, and interhospital transport need improvement. Addressing attrition rates among staff and greater empowerment of formally qualified registered intensivists in the private hospitals can enhance outcomes and cost control. Long-term post-ICU recovery care is often unaffordable or unavailable in many parts of the world. Engaging families in home care and providing training in basic caregiving tasks can improve outcomes and reduce costs. In areas with limited access to qualified professionals, training of lay community caregivers and practitioners can be beneficial. Multidisciplinary post-ICU clinics and necessary telephonic handholding can support home-based patients and their families. Standardizing prices of essential necessities and promoting rational practices are crucial. System-wide efforts and novel approaches like decentralization of critical care services are necessary to ensure holistic quality and cost-effectiveness, particularly in densely populated countries with resource limitations. These innovations will not only improve care but also enhance preparedness for future pandemics.
Lipoprotein(a) and functional outcome of acute ischemic stroke when discordant with low-density lipoprotein cholesterol
Authors: Dong Wenjing , Zhong Xiaoyan , Yuan Ke , Miao Mengyuan , Zhai Yujia , Che Bizhong , Xu Tan , Xu Xiang , Zhong Chongke 
Published: August 2023

AbstractBackgroundSeveral studies have indicated that residual cardiovascular risk might be associated with elevated lipoprotein(a) [Lp(a)] even in the setting of controlled low-density lipoprotein cholesterol (LDL-C). We aimed to prospectively examine the association between Lp(a) and unfavorable functional outcome among patients with acute ischemic stroke when Lp(a) and LDL-C were discordant.MethodsBased on samples from the Infectious Factors, Inflammatory Markers and Prognosis of Acute Ischemic Stroke study, 973 patients with baseline plasma Lp(a) levels were included. The primary outcome was the composite outcome of death or major disability (modified Rankin Scale score of 3–6) at 6 months. Logistic regression models were used to estimate the risk for the primary outcome. Discordance analyses were performed, using difference in percentile units (&gt;10 units), to detect the relative risk when Lp(a) and LDL-C were discordant.ResultsIn total, 201 (20.7%) participants experienced major disability or death at 6 months. The multivariable-adjusted odds ratio (OR) for the highest quartile was 1.88 [95% confidence interval (CI): 1.16–3.04] compared with the lowest quartile. Each 1-SD higher log-Lp(a) was associated with a 23% increased risk (95% CI: 2%–47%) for the primary outcome. Compared with the concordant group, the high Lp(a)/low LDL-C discordant group was associated with increased risk for the primary outcome (adjusted OR: 1.59, 95% CI: 1.01–2.52).ConclusionsElevated plasma Lp(a) levels were associated with increased risk of major disability and death at 6 months. Discordantly high Lp(a)/low LDL-C was associated with an unfavorable functional outcome, supporting the predictive potential of plasma Lp(a) after ischemic stroke, especially when discordant with LDL-C.Key messages What is already known on this topic Previous studies have indicated that a positive association between increased lipoprotein(a) [Lp(a)] and cardiovascular disease risk remained even in patients who achieved controlled low-density lipoprotein cholesterol (LDL-C) levels. The findings of studies exploring the association between Lp(a) and unfavorable clinical outcomes of stroke were inconsistent, and whether Lp(a) can predict the risk of unfavorable functional outcome in stroke patients when Lp(a) and LDL-C levels are discordant remains unknown. What this study adds Elevated plasma Lp(a) levels were associated with increased risk of major disability and death at 6 months beyond LDL-C levels in acute ischemic stroke patients. How this study might affect research, practice, or policy The combination of LDL-C-lowering therapies and Lp(a)-lowering therapies may have better clinical efficacy for patients with ischemic stroke, and it is of great clinical interest to further explore this possibility in dedicated randomized trials.
When Spirit Calls: A Phenomenological Approach to Healthy Voice-Hearers
Authors: Luhrmann Tanya Marie , Chen Xialing Ann , Baumeister David , Peters Emmanuelle 
Published: August 2023

Abstract
We present a mixed-methods study, from an anthropological perspective, of 22 healthy voice-hearers ie, people who report hearing voices but have no need for clinical care. They were interviewed using the Varieties Of Individual Voice-Experiences Scale (VOICES), a new scale assessing phenomenology, beliefs and relationships with voices, and their emotional and behavioral impact. Despite in many cases hearing voices daily, they report remarkably little distress, with almost all mentioning a positive impact on their life. Most interpreted their voices as spirits, and spoke of learning to understand, to manage, and even to train their experience of communicating with spirits productively. There was, however, considerable diversity in their voice experiences. Some described experiences they seemed to have discovered after starting a practice. Others described reaching for a practice to make sense of unusual experiences. This raises the possibility that cultural ideas about spirit communication may have two effects. On the one hand, they may help those who begin to hear voices involuntarily to interpret and manage their experience in a non-threatening way, through a meaning framework imposed on experiences. On the other hand, it also suggests that cultural ideas about spirit communication may lead some people to identify some thoughts as voices, and to come to feel that those thoughts are generated outside of themselves, through a meaning-framework shaping experiences. This should remind us that the culture-mind relationship is complex. There may be different kinds of phenomena described by individuals as “voices,” with practice and interpretation changing how these phenomena are experienced.
A comprehensive characterization of longevity and culling reasons in Canadian Holstein cattle based on various systematic factors
Authors: de Souza Taiana Cortez , Pinto Luis Fernando Batista , da Cruz Valdecy Aparecida Rocha , de Oliveira Hinayah Rojas , Pedrosa Victor Breno , Oliveira Gerson A , Miglior Filippo , Schenkel Flávio S , Brito Luiz F 
Published: August 2023

Abstract
The decision of premature culling cows directly impacts the profitability of dairy farms. A comprehensive characterization of the primary causes of culling reasons would greatly improve both management and selection objectives in dairy cattle breeding programs. Therefore, this study aimed to analyze the temporal frequencies of 34 culling reasons in Canadian Holstein cows. After data editing and quality control, records from 3,096,872 cows culled from 9,683 herds spread across Canada were used for the analyses covering the periods from 1996 to 2020. Reproductive issues were the main culling reason accounting for 23.02%, followed by milk production (20.82%), health (20.39%), conformation problems (13.69%), economic factors (13.10%), accidents (5.67%), age-related causes (1.67%), and workability (1.63%). Nearly fifty-eight percent of cows were culled after 47 months of age. The observed frequencies of culling due to economic factors were lower than expected from 1996 to 2014 and higher than expected between 2015 and 2020. Reproduction issues had the highest culling frequencies during fall (24.54%), winter (24.02%), and spring (22.51%), while health issues were the most frequent (22.51%) culling reason in the summer season. Health issues (25.50%) and milk production (27.71%) were the most frequent culling reasons in the provinces of Quebec and Ontario, respectively. Reproductive issues showed the highest frequency across climates based on the Köppen climate classification, except for Csb (Dry-summer subtropical or Mediterranean climate) and Bsk (Middle latitude steppe climate), which correspond to small regions in Canada, where production was the most frequent culling reason (29.42% and 21.56%, respectively). Reproductive and milk performance issues were the two main culling reasons in most ecozones, except in Boreal Shield and Atlantic Marine, where health issues had the highest frequencies (25.12 and 23.75%, respectively). These results will contribute to improving management practices and selective decisions to reduce involuntary culling of Holstein cows.
Ovarian antral follicles metabolize imidacloprid in vitro
Authors: Mourikes Vasiliki E , Santacruz-Márquez Ramsés , Deviney Ashley , Laws Mary J , Ulanov Alexander V , La Frano Michael R , Flaws Jodi A 
Published: August 2023

Abstract
Neonicotinoid insecticides are synthetic nicotine derivatives that have high affinity for invertebrate nicotine receptors and low affinity for mammalian nicotine receptors. However, imidacloprid (IMI), the most commonly used neonicotinoid, can be bioactivated by the liver in mammals to desnitro-imidacloprid, an intermediate metabolite that effectively binds and activates mammalian receptors. However, it is not known if other tissues such as the ovaries can metabolize IMI. Thus, the present study tested the hypothesis that ovarian antral follicles metabolize and bioactivate IMI. Antral follicles were dissected from the ovaries of CD-1 mice and cultured in media containing dimethyl sulfoxide or IMI (0.2–200 µg/ml) for 48 and 96 h. Media were subjected to liquid chromatography-mass spectrometry for detection of phase I IMI metabolites. Follicles from the cultures were used for gene expression analysis of metabolic enzymes associated with IMI metabolism. All IMI metabolites were detected at 48 and 96 h. Oxidized IMI intermediates were detected in media from cultured follicles, but not environmental controls. Reduced IMI intermediates were detected in media from cultured follicles and the environmental controls. At 48 h, IMI did not affect expression of any metabolic enzymes compared with control. At 96 h, IMI induced Cyp2e1 and Cyp4f18 compared with control. These data indicate that mouse ovarian follicles metabolize IMI and that IMI induces ovarian Cyp expression over time.
Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia
Authors: Yamada Mami , Warabi Eiji , Oishi Hisashi , Lira Vitor A. , Okutsu Mitsuharu 
Published: August 2023

AbstractOxidative stress plays an important role in skeletal muscle atrophy during cancer cachexia, and more glycolytic muscles are preferentially affected. Sequestosome1/SQSTM1 (i.e., p62), particularly when phosphorylated at Ser 349 (Ser 351 in mice), competitively binds to the Kelch‐like ECH‐associated protein 1 (Keap1) activating Nuclear factor erythroid 2‐related factor 2 (Nrf2). Nrf2 then stimulates the transcription of antioxidant/electrophile‐responsive elements in target genes. However, a potential role for p62 in the protection of muscle wasting in cachexia remains to be determined. Here, using the well‐established cachexia‐inducing model of Lewis Lung Carcinoma (LLC) in mice we demonstrate higher expression of antioxidant proteins (i.e., NQO1, HO‐1, GSTM1, CuZnSOD, MnSOD, and EcSOD) in the more oxidative and cachexia resistant soleus muscle than in the more glycolytic and cachexia prone extensor digitorum longus muscle. This was accompanied by higher p62 (total and phosphorylated) and nuclear Nrf2 levels in the soleus, which were paralleled by higher expression of proteins known to either phosphorylate or promote p62 phosphorylation (i.e., NBR1, CK1, PKCδ, and TAK1). Muscle‐specific p62 gain‐of‐function (i.e., in p62 mTg mice) activated Nrf2 nuclear translocation and increased the expression of multiple antioxidant proteins (i.e., CuZnSOD, MnSOD, EcSOD, NQO1, and GSTM1) in glycolytic muscles. Interestingly, skeletal muscle Nrf2 haplodeficiency blunted the increases of most of these proteins (i.e., CuZnSOD, EcSOD, and NQO1) suggesting that muscle p62 stimulates antioxidant protein expression also via additional, yet to be determined mechanisms. Of note, p62 gain‐of‐function mitigated glycolytic muscle wasting in LLC‐affected mice. Collectively, our findings identify skeletal muscle p62 as a potential therapeutic target for cancer cachexia.