bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Membrane-spanning Anti-Sigma Factors Regulate Vesiculation in Gut Bacteroidota
Authors: Pardue Evan J. , Sartorio Mariana G. , Jana Biswanath , Scott Nichollas E. , Beatty Wandy , Ortiz-Marquez Juan C. , Van Opijnen Tim , Hsu Fong-Fu , Potter Robert , Feldman Mario F. 
Published: July 2023

AbstractBacteroidota are abundant members of the human gut microbiota that shape the enteric landscape by modulating host immunity and degrading dietary- and host-derived glycans. These processes are at least partially mediated byOuterMembraneVesicles (OMVs). In this work, we developed a high-throughput screen to identify genes required for OMV biogenesis and its regulation inBacteroides thetaiotaomicron(Bt). Our screening led us to the identification of a novel family ofDualMembrane-spanningAnti-sigma factors (Dma), which regulate OMV biogenesis inBt. We employed molecular and multiomic analyses to demonstrate that deletion of Dma1, the founding member of the Dma family, results in hypervesiculation by modulating the expression of NigD1, which belongs to a family of uncharacterized proteins found throughout Bacteroidota. Dma1 has an unprecedented domain organization: it contains a C-terminal β-barrel embedded in the OM; its N-terminal domain interacts with its cognate sigma factor in the cytoplasm, and both domains are tethered via an intrinsically disordered region that traverses the periplasm. Phylogenetic analyses reveal that the Dma family is a unique feature of Bacteroidota. This study provides the first mechanistic insights into the regulation of OMV biogenesis in human gut bacteria.
Balancing the scales: Impact of irrigation and pathogen burden on potato blackleg disease and soil microbial communities
Authors: Keating Ciara , Kilbride Elizabeth , Stalham Mark A. , Nellist Charlotte , Milner Joel , Humphris Sonia , Toth Ian , Mable Barbara K. , Ijaz Umer Zeeshan 
Published: July 2023

AbstractUnderstanding the interaction between environmental conditions, crop yields, and soil health is crucial for sustainable agriculture in a changing climate. Management practices to limit disease are a balancing act. For example, in potato production, dry conditions favour common scab (Streptomycesspp.) and wet conditions favour blackleg disease (Pectobacteriumspp.). The exact mechanisms involved and how these link to changes in the soil microbiome is unclear. Our objectives were to test how irrigation management and bacterial pathogen load in potato seed stocks impact: i) crop yields; ii) disease development (blackleg/common scab); and iii) soil microbial community dynamics. We used stocks of seed potatoes with varyingPectobacteriumlevels (Jelly [high load], Jelly [low load], and Estima [Zero – noPectobacterium]). Stocks were grown under four irrigation regimes that differed in the timing and level of watering. The soil microbial communities were profiled using amplicon sequencing at 50% plant emergence and harvest and advanced bioinformatic analyses were used to correlate microbes to treatments and disease symptoms. Irrigation increased blackleg symptoms in the plots planted with stocks with low and high levels ofPectobacterium(22-34%) but not in the zero stock (2-6%). Not irrigating increased common scab symptoms (2-5%) and reduced crop yields. Irrigation did not impact the composition of the soil microbiome, but planting stock with a highPectobacteriumburden resulted in an increased abundance ofPlanctomycetota,Anaerolinea, andAcidobacteriaspecies within the microbiome. Ensemble quotient analysis highlightedAnaerolineaas highly associated with blackleg symptoms in the field. We conclude thatPectobacteriumpathogen load within seed stocks could have more substantial effects on soil communities than irrigation regimes.
Changes in cell morphology and function induced byNRASQ61R mutation in lymphatic endothelial cells
Authors: Yasue Shiho , Ozeki Michio , Nozawa Akifumi , Endo Saori , Ohnishi Hidenori 
Published: July 2023

AbstractRecently, a low-level somatic mutation inNRAS gene (c.182 A > G, Q61R) was identified in the specimens of patients with kaposiform lymphangiomatosis (KLA). However, it is unknown how these low-frequency mutated cells can affect the characterization and surrounding environment of their lesions. To understand the pathogenesis and association of these gene abnormalities, we establishedNRASQ61Rmutated lymphatic endothelial cells (LECs) transfected with lentivirus vector and undertook morphological and functional characterization, protein expression profiling, and metabolome analysis.NRASQ61Rhuman dermal LECs showed poor tube formation and high cell proliferation and migration ability with increasing ratios of mutated cells. Analysis of signaling pathways showed inactivation of the PIK3/AKT/mTOR pathway and hyperactivation of the RAS/MAPK/ERK pathway, which was improved by MEK inhibitor treatment. This study may show the theoretical circumstancesin vitroinduced byNRASQ61R-mutated cells in the affected lesions of KLA patients.
Circular economy practices in supply chain finance: a state-of-the-art review
Authors: Patra Soumya Prakash , Wankhede Vishal Ashok , Agrawal Rohit 
Published: July 2023

PurposeSupply chain finance is an emergent research area dealing with the financial performance of a firm throughout its supply chain. It has been drawing significant attention among industrial practitioners and researchers. However, there is need to identify improvements in supply chain finance (SCF) practices to ensure sustainable growth. In recent years, circular economy practices are being adopted worldwide with a motivation to achieve the 17 Sustainable Development Goals (SDGs). Moreover, integration of circular economy practices in the financial aspects of supply chain is still in infant age.Design/methodology/approachAdoption of circular SCF in firms enhances both restorative and regenerative capacities of the firm. In this regard, this study aims to review articles on circular practices in SCF. The study identified 329 articles related to circular practices and sustainable practices in SCF from the Scopus database. The shortlisted articles were reviewed and discussed.FindingsThe findings of the study help to recognize the most influential and productive research in circular SCF in terms of journals and trends. Further research is recommended to explore this area in depth to recognize potential integrating factors that help in smooth acceptance of circular finance in supply chains.Originality/valueBibliometric and network analyses were performed to identify research trends and networks in the field of circular SCF. In addition, emerging research themes in the field of circular SCF were identified and discussed, and research propositions are proposed to delineate future research directions.
Reconstruction of granite microstructure model using simulated annealing method and Voronoi tessellation
Authors: Chen Bin , Wang Yuan , Cui Shaoqing , Xiang Jiansheng , Latham John-Paul , Fu Jinlong 
Published: July 2023

PurposeAccurate presentation of the rock microstructure is critical to the grain-scale analysis of rock deformation and failure in numerical modelling. 3D granite microstructure modelling has only been used in limited studies with the mineral pattern often remaining poorly constructed. In this study, the authors developed a new approach for generating 2D and 3D granite microstructure models from a 2D image by combining a heterogeneous material reconstruction method (simulated annealing method) with Voronoi tessellation.Design/methodology/approachMore specifically, the stochastic information in the 2D image is first extracted using the two-point correlation function (TPCF). Then an initial 2D or 3D Voronoi diagram with a random distribution of the minerals is generated and optimised using a simulated annealing method until the corresponding TPCF is consistent with that in the 2D image. The generated microstructure model accurately inherits the stochastic information (e.g. volume fraction and mineral pattern) from the 2D image. Lastly, the authors compared the topological characteristics and mechanical properties of the 2D and 3D reconstructed microstructure models with the model obtained by direct mapping from the 2D image of a real rock sample.FindingsThe good agreements between the mapped and reconstructed models indicate the accuracy of the reconstructed microstructure models on topological characteristics and mechanical properties.Originality/valueThe newly developed reconstruction method successfully transfers the mineral pattern from a granite sample into the 2D and 3D Voronoi-based microstructure models ready for use in grain-scale modelling.
Developing brand meaning theory: the interplay of tangible attributes and intangible associations in relation to local food brands
Authors: Quest Jill 
Published: July 2023

Purpose
This study aims to explore brand meaning from a consumer perspective, identifying tangible attributes and intangible associations and their arrangement in brand meaning frameworks. Previous literature has focused on brand meaning flowing from intangible associations, and new insights are offered into the tangible attributes’ contribution to brand meaning.

Design/methodology/approach
A phenomenological approach was adopted, and meanings were gathered from lived experiences with consumers of local food brands. Quasi-ethnographic methods were used, including accompanied shopping trips to food fairs and local farm shops, kitchen visits and in-depth interviews in and around the county of Dorset in the south-west of England.

Findings
The findings demonstrate that tangible attributes have sensorial and functional brand meanings and are mentally processed. Both hierarchical and flatter patterned approaches are present when connecting attributes and associations. The hierarchical approach reflects both short and long laddering approaches; the flatter alternative offers an interwoven, patterned presentation.

Research limitations/implications
This is a small in-depth study of local food brands, and the findings cannot be generalised across other brand categories.

Practical implications
Local food brand practitioners can promote relevant sensorial (e.g. taste) and functional (e.g. animal welfare) attributes. These can be woven into appropriate intangible associations, creating producer stories to be communicated through their websites and social media campaigns.

Originality/value
A revised brand meaning theoretical framework updates previous approaches and develops brand meaning theory. The study demonstrates that tangible attributes have meaning and hierarchical connections across tangible attributes, and intangible associations should not always be assumed. An additional patterned approach is present that weaves attributes and associations in a holistic, non-hierarchical way.
An investigation of precursors of online impulse buying and its effects on purchase regret: role of consumer innovation
Authors: Sarwar Muhammad Arslan , Nasir Jawaria , Sarwar Binesh , Hussain Muzzammil , Abbas Ali 
Published: July 2023

Purpose
Impulsive buyers are a dream segment for retailers and marketers. Stimulants in the retail environment and cognitive aspects evoke a sudden urge the acquisition of products spontaneously. This paper aims to examine key cognitive aspects of impulsive buying behaviour and purchase regret in an online context.

Design/methodology/approach
An online survey was conducted to collect the data of 317 online consumers with the help of a convenience sampling technique. The structural equation modelling technique was carried out to establish the validity and reliability of measures and examine the proposed relational paths.

Findings
The study results suggest that cognitive aspects recede impulsive buying, resulting in purchase regret. The empirical findings on the impulsive buying behaviour and purchase regret to yield several important implications, including developing marketing strategies and policies to evoke the intentions for impulsive buying behaviour, consumer innovation and balancing the feelings of regret.

Practical implications
The study also provides some significant contributions to the literature on online impulse buying and its related paradigms.

Originality/value
This study mainly attempted to determine the precursors of online impulse buying and purchase regret from the perspective of hedonic and experiential consumption motivation and consumer innovation. Getting reflections from cognitive dissonance theory and the post purchase evaluation, a theoretical model was developed and empirically tested for impulsive online buyers.
Predicting turnover intention in Indonesian public organisations: investigating the effect of citizen and workplace incivility, and job insecurity
Authors: Wirawan Hillman , Salam Rudi , Normawati Normawati , Paramarta Vip , Sunarsi Denok 
Published: July 2023

PurposeThis study aimed to investigate the effect of citizens' uncivil behaviours on the turnover intention of public service personnel. It tested the moderated mediation role of job insecurity and workplace incivility. The conservation of resource (COR) theory was employed to explain the public service personnel's reactions to resource loss threats and the desire to conserve the remaining resources.Design/methodology/approachA longitudinal quantitative study design was used with a moderated mediation regression technique. Data were collected from 235 full-time public service personnel from five Indonesian public service organizations. The organizations included higher education, regional government institutions, and health, tourism, and transportation departments. All measures were valid and reliable for study purposes.FindingsThe citizen incivility's effect on turnover intention was mediated by job insecurity and moderated by workplace incivility. Citizen incivility positively influenced job insecurity only under high workplace incivility. Therefore, citizens' uncivil behaviours could not increase public service personnel's job insecurity and turnover intention without high workplace incivility.Originality/valueThis study contributes to the literature on citizens' incivility as a source of social stressors in Indonesian public organizations. The findings showed that citizens' hostile behaviours impact public employees' job insecurity only through workplace incivility.
Perceived risk and benefits of e-health consultation and their influence on user’s intention to use
Authors: Sahoo Anjan Kumar , Dash Ajitabh , Nayak Parameswar 
Published: July 2023

Purpose
This study aims to investigate the user’s behavior and intention to continue using e-health services by analyzing the factors influencing their decision. The stimuli–organism–behavior–consequence (SOBC) framework was used to assess how the risks and benefits of e-health influence both behavioral intention (BI) and continued use.

Design/methodology/approach
The hypotheses proposed for this study were tested with partial least square-based structural equation modeling. This study relied on the primary data collected from 572 respondents using convenient sampling.

Findings
This study examined the SOBC model’s four phases’ with the help of eight constructs. The conceptual model allowed the authors to examine 10 relationships to measure e-health adoption behavior in emerging nations like India. This study found that convenience, perceived risk and facilitating conditions are positively related to the effort and performance expectancy (PE) associated with e-health consultation. Only social influence is unrelated. This study also found a positive and substantial relationship between BI, effort and PE.

Originality/value
The study uses the unified theory of acceptance and use of technology and the SOBC paradigm to determine the factors influencing users’ intentions to use e-health. In addition to bringing new aspects to the existing literature on technology adoption and e-health consultation, the results of this study will aid e-health service providers in formulating strategies to promote the usage of e-health in emerging economies like India.
Wave‐based inversion at scale on graphical processing units with randomized trace estimation
Authors: Louboutin Mathias , Herrmann Felix J. 
Published: July 2023

AbstractThanks to continued performance improvements in software and hardware, wave‐equation‐based imaging technologies, such as full‐waveform inversion and reverse‐time migration, are becoming more commonplace. However, widespread adaptation of these advanced imaging modalities has not yet materialized because current implementations are not able to reap the full benefits from accelerators, in particular those offered by memory‐scarce graphics processing units. Through the use of randomized trace estimation, we overcome the memory bottleneck of this type of hardware. At the cost of limited computational overhead and controllable incoherent errors in the gradient, the memory footprint of adjoint‐state methods is reduced drastically. Thanks to this relatively simple to implement memory reduction via an approximate imaging condition, we are able to benefit from graphics processing units without memory offloading. We demonstrate the performance of the proposed algorithm on acoustic two‐ and three‐dimensional full‐waveform inversion examples and on the formation of image gathers in transverse tilted isotropic media.
Historical Military Conflict and Cross‐Border VC Performance: The Role of Ownership Control
Authors: Buchner Axel , Helbing Pia , Mohamed Abdulkadir , Yoon Hyungseok (David) 
Published: July 2023

AbstractThis study investigates the effect of historical military conflict (between the home countries of venture capital (VC) firms and portfolio companies) on the performance of cross‐border VC investments. Using exhaustive data on global cross‐border investments during 1986–2017, we find that adverse memories imprinted by historical military conflict have a negative effect on cross‐border performance as measured by internal rate of return and public market equivalent. We show that nation‐dyadic (i.e. political affinity) and ownership control strategy (i.e. board seat and syndication)‐related contingencies moderate the relationship between historical military conflict and cross‐border performance. Collectively, our findings shed light on the presence of intergroup interaction challenges and mistrust when investing in cross‐border VC deals and demonstrate channels to mitigate their adverse effects.
Mechanisms of bariatric surgery for weight loss and diabetes remission
Authors: Yin Mengsha , Wang Yao , Han Mingyue , Liang Ruishuang , Li Shanshan , Wang Guixia , Gang Xiaokun 
Published: July 2023

AbstractObesity and type 2 diabetes(T2D) lead to defects in intestinal hormones secretion, abnormalities in the composition of bile acids (BAs), increased systemic and adipose tissue inflammation, defects of branched‐chain amino acids (BCAAs) catabolism, and dysbiosis of gut microbiota. Bariatric surgery (BS) has been shown to be highly effective in the treatment of obesity and T2D, which allows us to view BS not simply as weight‐loss surgery but as a means of alleviating obesity and its comorbidities, especially T2D. In recent years, accumulating studies have focused on the mechanisms of BS to find out which metabolic parameters are affected by BS through which pathways, such as which hormones and inflammatory processes are altered. The literatures are saturated with the role of intestinal hormones and the gut‐brain axis formed by their interaction with neural networks in the remission of obesity and T2D following BS. In addition, BAs, gut microbiota and other factors are also involved in these benefits after BS. The interaction of these factors makes the mechanisms of metabolic improvement induced by BS more complicated. To date, we do not fully understand the exact mechanisms of the metabolic alterations induced by BS and its impact on the disease process of T2D itself. This review summarizes the changes of intestinal hormones, BAs, BCAAs, gut microbiota, signaling proteins, growth differentiation factor 15, exosomes, adipose tissue, brain function, and food preferences after BS, so as to fully understand the actual working mechanisms of BS and provide nonsurgical therapeutic strategies for obesity and T2D.
Phylogenomic and syntenic data demonstrate complex evolutionary processes in early radiation of the rosids
Authors: Liu Luxian , Chen Mengzhen , Folk Ryan A. , Wang Meizhen , Zhao Tao , Shang Fude , Soltis Douglas E. , Li Pan 
Published: July 2023

AbstractSome of the most vexing problems of deep level relationship that remain in angiosperms involve the superrosids. The superrosid clade contains a quarter of all angiosperm species, with 18 orders in three subclades (Vitales, Saxifragales and core rosids) exhibiting remarkable morphological and ecological diversity. To help resolve deep‐level relationships, we constructed a high‐quality chromosome‐level genome assembly for Tiarella polyphylla (Saxifragaceae) thus providing broader genomic representation of Saxifragales. Whole genome microsynteny analysis of superrosids showed that Saxifragales shared more synteny clusters with core rosids than Vitales, further supporting Saxifragales as more closely related with core rosids. To resolve the ordinal phylogeny of superrosids, we screened 122 single copy nuclear genes from genomes of 36 species, representing all 18 superrosid orders. Vitales were recovered as sister to all other superrosids (Saxifragales + core rosids). Our data suggest dramatic differences in relationships compared to earlier studies within core rosids. Fabids should be restricted to the nitrogen‐fixing clade, while Picramniales, the Celastrales‐Malpighiales (CM) clade, Huerteales, Oxalidales, Sapindales, Malvales and Brassicales formed an “expanded” malvid clade. The Celastrales‐Oxalidales‐Malpighiales (COM) clade (sensu APG IV) was not monophyletic. Crossosomatales, Geraniales, Myrtales and Zygophyllales did not belong to either of our well‐supported malvids or fabids. There is strong discordance between nuclear and plastid phylogenetic hypotheses for superrosid relationships; we show that this is best explained by a combination of incomplete lineage sorting and ancient reticulation.
Health services utilization by fibromyalgia patients from two ethnic groups
Authors: Treister‐Goltzman Yulia , Peleg Roni , Sagy Iftach , Menashe Idan 
Published: July 2023

AbstractAimThe cost to the healthcare system of management and treatment for fibromyalgia patients is high. The aims of the study were to identify and compare factors associated with the use of healthcare services among fibromyalgia patients in southern Israel from two ethnic groups.MethodsA cross‐sectional study of patients insured in the southern district of the Clalit Healthcare Services in Israel in 2019–2020. The data were collected from the central computerized system. Multivariable regression models were developed for healthcare services utilization.ResultsDuring the study period, 7686 members were diagnosed with fibromyalgia. The median for specialist consultations was 47 and for imaging tests was eight. About 47% made emergency room visits and 25% were hospitalized. The median of imaging tests was significantly higher in Jewish patients than in Arab patients (8 vs. 6; p = .000). In contrast, a significantly higher rate of Arab patients visited the Emergency Room at least once (51.6% vs. 46.75%; p = .000) and they had a higher median number or Emergency Room visits (2 vs. 1; p = .003), compared with Jewish patients. In the Arab group there was a strong effect coefficient for another localized pain syndrome with specialist consultations (odds ratio [OR] 1.699; 95% confidence interval [CI] 1.266–2.241) and imaging tests (OR 2.511; 95% CI 1.496–4.146).ConclusionsThe utilization rate of healthcare services is high among fibromyalgia patients. The factors associated with high healthcare utilization are different in the two ethnic groups. Future studies could show if interventions designed to address modifiable factors could reduce the overutilization of healthcare services.