bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation On The Entropy Supplying Capability Of Smartphone Sensors
Authors: Zhang Dinghua , Wu Shihao , Li Yang , Pan Quan 
Published: September 2023

Abstract
Random numbers are very important for the security of computer system. However, generating qualified random numbers is difficult because we cannot always successfully introduce dedicated random number hardware into computer system. Although most operating systems provide random number generation capabilities, the effective entropy supply is still dependent on the hardware platform including memory and clocks etc. However, obtaining hardware events such as clocks requires system privileges, which is not conducive for entropy estimation at the application layer. In contrast, data related to the sensor hardware can be extracted directly at the application layer. These sensor data contain some randomness and may be used as a noise source. In this way, applications can use these sensors to implement their own proprietary random number generators. Before taking these sensors as the noise source, it is necessary to fully evaluate their entropy supply capability. In this paper, 300 Android smartphones and 30 iOS smartphones are selected as samples and their sensor entropy supply capabilities are comprehensively evaluated. Based on the entropy evaluation results, we give some suggestions on how to generate random numbers using these sensor data. We first design a framework for evaluating the entropy supply capability for smartphone sensors, based on the min-entropy estimation method proposed in NIST SP 800-90B. According to this framework, we simulate stationary and mobile working states for each smartphone, and collect sufficient sensor data as the min-entropy estimation dataset. The min-entropy estimation results show that in the stationary working state, each ACCELEROMETER sensor data collection can obtain at least 1.5 bits of entropy in Android, while each GYROSCOPE sensor data collection can obtain at least 20 bits of entropy in iOS. In the mobile working state, each ACCELEROMETER sensor data collection can obtain at least 1.9 bits of entropy, while each GYROSCOPE sensor data acquisition in iOS system can obtain at least 27 bits of entropy. This means that we can still get a stable entropy output from the sensor even when the smartphone is in stationary working state. Statistical analysis of the data using cross correlation methods suggests it is hard for an attacker to guess or predict the random numbers generated by a smartphone through another smartphone put in the similar external environment.
Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial
Authors: Justice Jamie N , Leng Xiaoyan I , LeBrasseur Nathan K , Tchkonia Tamara , Kirkland James L , Mitin Natalia , Liu Yongmei , Kritchevsky Stephen B , Nicklas Barbara J , Ding Jingzhong 
Published: September 2023

Abstract
Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may improve metabolic function in part by reducing cellular senescence and the pro-inflammatory senescence-associated phenotype (SASP). We conducted an ancillary investigation of an 18-week randomized controlled trial (RCT) of CR (n = 31) or Control (n = 27) in 58 middle-aged/older adults (57.6 ± 5.8 years; 75% Women) with obesity and prediabetes. We measured mRNA expression of select senescence and apoptosis genes in blood CD3 + T cells (qRT-PCR) and a panel of 25 plasma SASP proteins (Luminex/multiplex; ELISA). Participants randomized to CR lost −10.8 ± 0.9 kg (−11.3% ± 5.4%) over 18 weeks compared with +0.5 ± 0.9 kg (+0.03% ± 3.5%) in Control group. T-cell expression of senescence biomarkers, p16INK4a and p21CIP1/WAF1, and apoptosis markers, BCL2L1 and BAK1, was not different between CR and Control groups in age, race, and sex-adjusted mixed models (p &gt; .05, all). Iterative principal axis factor analysis was used to develop composite SASP Factors, and the Factors comprising TNFRI, TNFRII, uPAR, MMP1, GDF15, OPN, Fas, and MPO were significantly altered with CR intervention (age, sex, race-adjusted mixed model time × treatment F = 4.17, p ≤ .05) and associated with the degree of weight loss (R2 = 0.12, p ≤ .05). Our study provides evidence from an RCT that specific circulating biomarkers of senescent cell burden are changed by CR in middle-aged and older adults with obesity and prediabetes. Future studies compare tissue and circulating levels of p16INK4a and pro-inflammatory SASP biomarkers in other populations, and interventions.
Aging-Related Mitochondrial Dysfunction Is Associated With Fibrosis in Benign Prostatic Hyperplasia
Authors: Adrian Alexis E , Liu Teresa T , Pascal Laura E , Bauer Scott R , DeFranco Donald B , Ricke William A 
Published: September 2023

Abstract

Background
Age is the greatest risk factor for lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Although LUTS/BPH can be managed with pharmacotherapy, treatment failure has been putatively attributed to numerous pathological features of BPH (eg, prostatic fibrosis, inflammation). Mitochondrial dysfunction is a hallmark of aging; however, its impact on the pathological features of BPH remains unknown.

Methods
Publicly available gene array data were analyzed. Immunohistochemistry examined mitochondrial proteins in the human prostate. The effect of complex I inhibition (rotenone) on a prostatic cell line was examined using quantitative polymerase chain reaction, immunocytochemistry, and Seahorse assays. Oleic acid (OA) was tested as a bypass of complex I inhibition. Aged mice were treated with OA to examine its effects on urinary dysfunction. Voiding was assessed longitudinally, and a critical complex I protein measured.

Results
Mitochondrial function and fibrosis genes were altered in BPH. Essential mitochondrial proteins (ie, voltage-dependent anion channels 1 and 2, PTEN-induced kinase 1, and NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, mitochondrial [NDUFS3]) were significantly (p &lt; .05) decreased in BPH. Complex I inhibition in cultured cells resulted in decreased respiration, altered NDUFS3 expression, increased collagen deposition, and gene expression. OA ameliorated these effects. OA-treated aged mice had significantly (p &lt; .05) improved voiding function and higher prostatic NDUFS3 expression.

Conclusions
Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. OA partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this investigation offer a heretofore unexplored cellular target of interest for the management of LUTS/BPH.
Childhood Parental Disfavoritism and Chinese Adults’ Psychological Well-Being in Middle and Later Life: The Moderating Effect of Gender
Authors: Hou Yifei , Suitor J Jill 
Published: September 2023

Abstract

Objectives
Parental differential treatment of children, particularly disfavoritism, has been found to detrimentally affect adult children’s psychological well-being in the United States. However, no study has investigated the long-reaching influence of parental disfavoritism in China, where there is an absence of equal treatment norms. Drawing from theories of social comparison, life course, and gender dynamics in China, we tested how perceptions of childhood parental disfavoritism affect midlife and older Chinese adults’ depressive symptoms, and how the effects differ by own and parent’s gender.

Methods
Random-intercept models were used based on a sample of 17,682 midlife and older Chinese adults, drawn from 5 waves of China Health and Retirement Longitudinal Study.

Results
Recollections of childhood parental disfavoritism were associated with higher depressive symptoms among Chinese adults. Perceptions of paternal disfavoritism predicted both men’s and women’s depressive symptoms, whereas perceptions of maternal disfavoritism predicted women’s depressive symptoms only. Paternal disfavoritism was more detrimental than maternal disfavoritism, but only for men. Maternal disfavoritism was more detrimental for women than men.

Discussion
These findings shed light on the universality of the long-reaching detrimental effect of perceptions of parental disfavoritism across cultures as well as the unique gendered patterns in China shaped by patriarchy. Findings suggest that the implementation of Three-Child Policy in China should be accompanied with parental education programs involving fathers on equal treatment of children.
Sarcopenia Transitions and Influencing Factors Among Chinese Older Adults With Multistate Markov Model
Authors: Sun Boran , Li Shatao , Wang Yanbo , Xiao Wenbo , Zhao Han , Liu Xuewei , Liu Yang , Lu Xinlin , Gao Bei , Zhou Jiangtao , Wang Bingyi , Wang Yuan , Chen Yongjie , Lu Wenli 
Published: September 2023

Abstract

Background and Objectives
Little is known about the sarcopenia transition process across different stages among Chinese community-dwelling older adults. We aimed to explore dynamic transitions of sarcopenia and its influencing factors in Chinese older adults.

Research Design and Methods
Data were derived from the China Health and Retirement Longitudinal Study. A total of 2856 older adults with complete data in the 2011, 2013, and 2015 waves were included in our study. Participants were categorized into 3 states: no sarcopenia, possible sarcopenia, and sarcopenia according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. Continuous-time multistate Markov model was performed to estimate the 1-year transition probabilities and the associated factors of sarcopenia transitions. The association strength was expressed as hazard ratio and 95% confidence interval.

Results
The progression and reversion rates between no sarcopenia and sarcopenia state were 6.01 and 9.20 per 100 person-years, respectively. The 1-year progression probability to possible sarcopenia was higher compared with the likelihood of moving to the sarcopenia state (0.127 vs 0.034). The reversion probability to no sarcopenia was also higher among those with possible sarcopenia (0.281 vs 0.157). Older age, rural living, worse cognition status, higher chronic disease numbers, and lower nutrition status measured by body mass index accelerated the sarcopenia progression. Cognition status and body mass index level were related to higher chances of reverting.

Discussion and Implications
Possible sarcopenia might be a critical time window to promote sarcopenia reversion. Timely interventions aimed at delaying the progression and facilitating sarcopenia recovery should focus on improving cognitive function and nutrition levels.
Environmental DNA complements scientific trawling in surveys of marine fish biodiversity
Authors: Veron Pierre , Rozanski Romane , Marques Virginie , Joost Stéphane , Deschez Marie Emilie , Trenkel Verena M , Lorance Pascal , Valentini Alice , Polanco F. Andrea , Pellissier Loïc , Eme David , Albouy Camille 
Published: September 2023

Abstract
Environmental DNA (eDNA) metabarcoding is a method to detect taxa from environmental samples. It is increasingly used for marine biodiversity surveys. As it only requires water collection, eDNA metabarcoding is less invasive than scientific trawling and might be more cost effective. Here, we analysed data from both sampling methods applied in the same scientific survey targeting Northeast Atlantic fish in the Bay of Biscay. We compared the methods regarding the distribution of taxonomic, phylogenetic, and functional diversity. We found that eDNA captured more taxonomic and phylogenetic richness than bottom trawling and more functional richness at the local scale. eDNA was less selective than trawling and detected species in local communities spanning larger phylogenetic and functional breadths, especially as it detected large pelagic species that escaped the trawl, even though trawling detected more flat fish. eDNA indicated differences in fish community composition that were comparable to those based on trawling. However, consistency between abundance estimates provided by eDNA metabarcoding and trawl catches was low, even after accounting for allometric scaling in eDNA production. We conclude that eDNA metabarcoding is a promising method that can complement scientific trawling for multi-component biodiversity monitoring based on presence/absence, but not yet for abundance.
A non-contractual approach to smart contracts
Authors: Gamper Florian 
Published: September 2023

Abstract
This article adds to the debate on what, legally speaking, smart contracts are and what they should be. Currently, much of this debate focuses on the relationship between smart contracts and legal contracts, overlooking that other legal categories may also be appropriate. This article suggests that the concept of abandonment can be fruitfully applied to smart contracts. Using the concept of abandonment has the advantage of allowing smart contracts, as close as legally possible, to be utilized as machines (or using the terminology suggested by Vitalik Buterin, founder of Etherium, as a ‘persistent script’). It would also make other issues, like the interpretation of smart contracts, easier to deal with. The argument is not that smart contracts can never be legal contracts; rather, it is suggested that, prima facie, users should have the choice of utilizing smart contracts as legal contracts or as machines.
Nodal Sets of Eigenfunctions of Sub-Laplacians
Authors: Eswarathasan Suresh , Letrouit Cyril 
Published: September 2023

Abstract
Nodal sets of eigenfunctions of elliptic operators on compact manifolds have been studied extensively over the past decades. In this note, we initiate the study of nodal sets of eigenfunctions of hypoelliptic operators on compact manifolds, focusing on sub-Laplacians. A standard example is the sum of squares of bracket-generating vector fields on compact quotients of the Heisenberg group. Our results show that nodal sets behave in an anisotropic way, which can be analyzed with standard tools from sub-Riemannian geometry such as sub-Riemannian dilations, nilpotent approximation, and desingularization at singular points. Furthermore, we provide a simple example demonstrating that for sub-Laplacians, the Hausdorff measure of nodal sets of eigenfunctions cannot be bounded above by $\sqrt \lambda $, which is the bound conjectured by Yau for Laplace–Beltrami operators on smooth manifolds.
An Eigenvalue Problem for Prescribed Curvature Equations
Authors: Lee Taehun 
Published: September 2023

Abstract
We study an eigenvalue problem for prescribed $\sigma _{k}$-curvature equations of star-shaped, $k$-convex, closed hypersurfaces. We establish the existence of a unique eigenvalue and its associated hypersurface, which is also unique, provided that the given data is even. Moreover, we show that the hypersurface must be strictly convex. A crucial aspect of our proof involves deriving uniform estimates in $p$ for $L_{p}$-type prescribed curvature equations.
Impact of COVID-19 pandemic on accredited programs and graduates who sat for the American Society for Clinical Pathology–Board of Certification Examination: program directors’ perspective
Authors: Duzan Dana , Fong Karen , Freeman Vicki S , Goodyear Nancy , Nadder Teresa S , Spiczka Amy , Taff Teresa , Tanabe Patricia 
Published: September 2023

Abstract

Objective
Health professions education programs were severely affected by the COVID-19 pandemic at clinical and didactic training levels. The purpose for this American Society for Clinical Pathology–Board of Certification (BOC) study was to determine the impact of the COVID-19 pandemic on the graduates who sat for BOC certification in their respective professional disciplines from the perspective of program directors (PDs). A separate article will be published on the graduates’ perspective.

Methods
A survey was sent to all PDs from the National Accrediting Agency for Clinical Laboratory Science, Accrediting Bureau of Health Education Schools, and Commission on Accreditation of Allied Health Education Programs, accredited programs whose graduates are certified by the BOC, to determine the impact of COVID-19 on healthcare graduates and education programs during the pandemic.

Results
A total of 201 PDs responded. All programs consistently reported that the pandemic had a negative impact on their students’ BOC pass rate and scores. When asked what educational formats were used, all groups used virtual live lectures and recorded lectures. University programs were found to use more online student laboratories and simulation laboratory sessions than the hospital programs, affecting the psychomotor skills of their students.

Conclusion
The results indicated that the effects from the COVID-19 pandemic were related to the inherent differences between hospital and university programs. This study revealed that the pandemic affected university programs more than hospital programs.
Oxford to Prague: Orthodox Insular Texts in Bohemia
Authors: Hanna Ralph 
Published: September 2023

Abstract
Owing to protracted investigations of heresy, much of John Wyclif’s oeuvre is now available, not in insular, but only in Bohemian manuscripts. However, the mechanisms of such transmission have remained murky, in spite of Anne Hudson’s magisterial investigations in Czech libraries. This essay looks at evidence for an analogous, yet orthodox, transmission, earlier and, before 1407, considerably more prolific than the Wycliffite example. This involves Oxonian texts written for preachers; these had a lively and early Bohemian circulation, dating back to the foundations of the Charles University, Prague.
Underlying causes for prevalent false positives and false negatives in STARR-seq data
Authors: Ni Pengyu , Wu Siwen , Su Zhengchang 
Published: September 2023

Abstract
Self-transcribing active regulatory region sequencing (STARR-seq) and its variants have been widely used to characterize enhancers. However, it has been reported that up to 87% of STARR-seq peaks are located in repressive chromatin and are not functional in the tested cells. While some of the STARR-seq peaks in repressive chromatin might be active in other cell/tissue types, some others might be false positives. Meanwhile, many active enhancers may not be identified by the current STARR-seq methods. Although methods have been proposed to mitigate systematic errors caused by the use of plasmid vectors, the artifacts due to the intrinsic limitations of current STARR-seq methods are still prevalent and the underlying causes are not fully understood. Based on predicted cis-regulatory modules (CRMs) and non-CRMs in the human genome as well as predicted active CRMs and non-active CRMs in a few human cell lines/tissues with STARR-seq data available, we reveal prevalent false positives and false negatives in STARR-seq peaks generated by major variants of STARR-seq methods and possible underlying causes. Our results will help design strategies to improve STARR-seq methods and interpret the results.
Magnitude, Patterns, and Associated Predictors of Cardiovascular Events in Tetanus: A 2-Year, Single-Center, Ambidirectional Cohort Study Involving 572 Patients
Authors: Pham Oanh Kieu Nguyet , Tran Bao Nhu , Duong Minh Cuong , Do Thi Cam Nhung , Pham Thi Lieu , Lam Minh Yen , Thwaites Louise , Nguyen Van Hao 
Published: September 2023

Abstract

Background
Cardiovascular events (CEs) remain the leading cause of death in patients with tetanus. We examined the incidence, patterns, and associated predictors of CEs among patients with tetanus in Vietnam.

Methods
An ambidirectional cohort study was conducted on hospitalized adult patients with tetanus at the Hospital for Tropical Diseases between 2019 and 2020. Information on demographics, tetanus disease, CEs and outcomes were collected.

Results
Among all 572 included patients, CEs accounted for 10.8% (95%CI 8.6–13.7%) and included Takotsubo cardiomyopathy (40.3%, 95%CI 29.0–52.8%), arrhythmia (19.4%, 95%CI 11.4–30.9%), sudden cardiac arrest (16.1%, 95%CI 9.0–27.2%), myocardial infarction (11.3%, 95%CI 5.6–21.5%), heart failure (6.5%, 95%CI 2.5–15.4%) and pulmonary embolism (6.5%, 95%CI 2.5–15.4%). CEs occurred from day 5 to 20 of illness. Among 62 CE patients, 21% (95%CI 12.7–32.6%) died and 61.3% (95%CI 48.9–72.4%) developed autonomic nervous system dysfunction (ANSD). Three-fourths (24/32) of patients with Takotsubo cardiomyopathy or myocardial infarction had ANSD. CEs were significantly associated with modified Ablett scores (AOR = 2.42, 95%CI 1.1–5.6, P = .04), underlying diseases (AOR = 2.7, 95%CI 1.1–6.8, P = .04) and overweight (AOR = 0.18, 95%CI .04–.8, P = .02).

Conclusions
CEs are not rare and associated with high mortality. The most common CE is Takotsubo cardiomyopathy. CEs can occur at any stage of illness, with or without ANSD. To prevent mortality, it is pivotal to screen CEs in patients with tetanus, especially those with underlying diseases, high modified Ablett scores, and a normal or low BMI. More studies are needed to fully elucidate the impact of ANSD on the cardiovascular function and the CE associated mortality in tetanus.
Remdesivir Is Associated With Reduced Mortality in COVID-19 Patients Requiring Supplemental Oxygen Including Invasive Mechanical Ventilation Across SARS-CoV-2 Variants
Authors: Mozaffari Essy , Chandak Aastha , Gottlieb Robert L , Chima-Melton Chidinma , Read Stephanie H , Lee EunYoung , Der-Torossian Celine , Gupta Rikisha , Berry Mark , Hollemeersch Stijn , Kalil Andre C 
Published: September 2023

Abstract

Background
This comparative effectiveness study investigated the effect of remdesivir on in-hospital mortality among patients hospitalized for coronavirus disease 2019 (COVID-19) requiring supplemental oxygen including low-flow oxygen (LFO), high-flow oxygen/noninvasive ventilation (HFO/NIV), or invasive mechanical ventilation/extracorporeal membrane oxygenation (IMV/ECMO) across variant of concern (VOC) periods.

Methods
Patients hospitalized for COVID-19 between December 2020 and April 2022 and administered remdesivir upon admission were 1:1 propensity score matched to patients not administered remdesivir during their COVID-19 hospitalization. Analyses were stratified by supplemental oxygen requirement upon admission and VOC period. Cox proportional hazards models were used to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for 14- and 28-day mortality.

Results
Patients treated with remdesivir (67 582 LFO, 34 857 HFO/NIV, and 4164 IMV/ECMO) were matched to non-remdesivir patients. Unadjusted mortality rates were significantly lower for remdesivir-treated patients at 14 days (LFO: 6.4% vs. 8.8%; HFO/NIV: 16.8% vs. 19.4%; IMV/ECMO: 27.8% vs. 35.3%) and 28 days (LFO: 9.8% vs. 12.3%; HFO/NIV: 25.8% vs. 28.3%; IMV/ECMO: 41.4% vs. 50.6%). After adjustment, remdesivir treatment was associated with a statistically significant reduction in in-hospital mortality at 14 days (LFO: aHR, 0.72; 95% CI, 0.66–0.79; HFO/NIV: aHR, 0.83; 95% CI, 0.77–0.89; IMV/ECMO: aHR, 0.73; 95% CI, 0.65–0.82) and 28 days (LFO: aHR, 0.79; 95% CI, 0.73–0.85; HFO/NIV: aHR, 0.88; 95% CI, 0.82–0.93; IMV/ECMO: aHR, 0.74; 95% CI, 0.67–0.82) compared with non-remdesivir treatment. Lower risk of mortality among remdesivir-treated patients was observed across VOC periods.

Conclusions
Remdesivir treatment is associated with significantly reduced mortality among patients hospitalized for COVID-19 requiring supplemental oxygen upon admission, including those requiring HFO/NIV or IMV/ECMO with severe or critical disease, across VOC periods.