bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug utilization research in Peru: Is real-world data available?
Authors: Rodríguez-Tanta L. Yesenia , Garavito Farro Héctor , Freitas Leal Lisiane , Salas Maribel , Elseviers Monique M. , Lopes Luciane Cruz 
Published: January 2023

Background: Drug utilization research (DUR) is used to provide evidence-based data to inform policies and make decisions. The aim of this study was to map and describe available data sources for drug utilization research in Peru.Methods: We performed a search of data sources providing information on medication use on the website of governmental organizations. We also conducted a literature review using PubMed, LILACs, and BVS. Independently, researchers screened eligible data sources. Data characterization included accessibility, coverage data provider, type of data sources, and setting. We performed a descriptive analysis.Results: We identified seven data sources, CENAFyT, ICI, IDI (SISMED), and ENSUSALUD from MINSA, and CRI-ESSALUD, SGSS/ESSI, and ENSSA from ESSALUD. These presented information on adverse drug reactions (n = 2), drug consumption, and distribution (n = 2), prescription and drug dispensing (n = 1), and surveys addressed to medication users (n = 2). ENSUSALUD was the only data source publicly available. VIGIFLOW and ENSUSALUD have a national granularity from the public and private sectors. The setting of the data sources was both hospital and ambulatory care. Two data sources have individual-level data on adverse drug reactions and one on prescriptions. Four studies on drug utilization research in Peru were derived from ENSUSALUD.Conclusion: In Peru, few data sources are available for drug utilization research. There is an increased need to monitor medications for decision-making purposes. Local and international initiatives and partnerships of the government with academic institutions and the private sector might be a good strategy to increase the transparency of health data and for supporting decision-making using drug utilization research.
SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement
Authors: Botermans Wouter , Koole Michel , Van Laere Koen , Savidge Jonathan R. , Kemp John A. , Sunaert Stefan , Duffy Maeve M. , Ramael Steven , Cesura Andrea M. , D’Ostilio Kevin , Gossen Denis , Madsen Torsten M. , Lodeweyckx Thomas , de Hoon Jan 
Published: January 2023

Background: Current treatments for progressive neurodegenerative disorders characterized by cognitive impairment either have limited efficacy or are lacking altogether. SDI-118 is a small molecule which modulates the activity of synaptic vesicle glycoprotein 2A (SV2A) in the brain and shows cognitive enhancing effects in a range of animal models of cognitive deficit.Methods: This first-in-human study evaluated safety, tolerability, and pharmacokinetics/pharmacodynamics of SDI-118 in single ascending oral doses up to 80 mg administered to 32 healthy male subjects. Brain target occupancy was measured in eight subjects using positron emission tomography with PET-ligand [11C]-UCB-J. Food effect was assessed in seven subjects. Mood state was regularly evaluated using standardized questionnaires, and resting state fMRI data were analyzed as exploratory objectives.Key Results: At all doses tested, SDI-118 was well tolerated and appeared safe. Adverse events were mainly dizziness, hypersomnia, and somnolence. All were mild in intensity and increased in frequency with increasing administered dose. No dose-limiting adverse reactions were observed at any dose. SDI-118 displayed a linear pharmacokinetic profile with no significant food effect. Brain penetration and target engagement were demonstrated by a dose-proportional SV2A occupancy.Conclusion: Single oral doses of SDI-118 up to 80 mg were very well tolerated in healthy male subjects. Dose-proportional SV2A occupancy in the brain was demonstrated with brain imaging. Adverse effects in humans mainly occurred in higher dose ranges, with high occupancy levels, and were all mild and self-limiting. These data support further clinical exploration of the compound in patients with cognitive disorders.Clinical Trial Registration:https://clinicaltrials.gov/, identifier NCT05486195
Spectral analysis of Monte Carlo calculated fluence correction and cema conversion factors for high-energy photon beams at different depths
Authors: Roers Julian , Czarnecki Damian , Alissa Mohamad , Zink Klemens 
Published: January 2023

Purpose: The aim of this study is to investigate the depth-dependent detector response of detailed thimble air-filled ionization chambers by calculating spectral charged particle fluence correction factors at different depths in water. Those spectral correction factors will help to understand, how the detector response varies at different depths and what kind of influences disparate effects have on the spectral detector response.Methods: The cema-approach can be used to obtain spectral charged particle fluence-based correction factors for various measurement conditions by substituting the commonly well-known dose conversion factor with a conversion factor based on the dosimetric quantity cema (“converted-energy per unit mass”). The resulting spectral fluence correction factors were calculated with the EGSnrc software toolkit and analyzed for two air-filled cylindrical ionization chambers (PTW type 31021 Semiflex 3D, SNC125c™) at different depths in a water phantom irradiated with a 6 MV linear accelerator x-ray spectrum. The ionization chamber models have been stepwise decomposed to investigate the perturbation caused by internal and external effects on the fluence distribution within the detector.Results: Monte Carlo calculated fluence-based perturbation correction factors revealed that for all investigated detectors, considerable fluence disturbances occur, especially in the build-up region of depth-dose curves. Our results have shown that even slight variations in depth can have major consequences on the differential charged particle fluence within the ionization chamber, mainly due to internal cavity-specific effects. Furthermore, the results showed that in the case of relative dose measurements, the depth-depending detector response can significantly differ from unity in a range of 1.4%–2.8% depending on the ionization chamber design.Conclusion: The complexity of different effects on the fluence disturbance could be broken down with regard to their influence on the spectral fluence distribution in the sensitive volume of the investigated detectors. It could be demonstrated, that the displacement of water is a depth-depending effect, which can not be compensated or corrected ideally for each investigated water depth by the shift of the effective point of measurement. Generally, the spectral analysis of those energy-dependent correction factors serves to a deeper understanding of the detector response under various conditions.
Sustainable leadership and wellbeing of healthcare personnel: A sequential mediation model of procedural knowledge and compassion
Authors: Abid Ghulam , Contreras Francoise , Rank Susanne , Ilyas Sehrish 
Published: January 2023

IntroductionIn healthcare organizations, saving patients’ lives while maintaining the staff’s wellbeing, performance and competencies were challenging during the COVID-19 pandemic. Although the complexity of healthcare settings is widely recognized, the pandemic evidenced the necessity of attending to the employees’ wellbeing in such a sector. This research aims to examine the effect of sustainable leadership on wellbeing of healthcare personnel. Furthermore, we also evaluate whether procedural knowledge and compassion act as mediators in such a relationship.MethodsThe hypothesized model was tested in healthcare organizations in a South Asian country, and the data were collected during the pandemic crisis. A total of 366 health personnel (physicians and nurses) participated in this research. With Hayes’ PROCESS macro, we examined all the direct and indirect paths, including sequential mediation.ResultsThe findings confirm the impact of sustainable leadership on wellbeing and this relationship is also mediated by procedural knowledge and compassion.Discussion/conclusionSustainable leadership fosters wellbeing among healthcare workers via the sequential mediation of procedural knowledge and compassion. Study findings suggest that sustainable leaders can trigger procedural knowledge among employees which in turn crafts the state of compassion in them that leads to their wellbeing. Theoretical and practical implications are discussed in light of study findings.
Long-term trends in the incidence of depressive disorders in China, the United States, India and globally: A comparative study from 1990 to 2019
Authors: Wang Shuwen , Lu Tianhuan , Sun Jinyi , Huang Lihong , Li Ruiqing , Wang Tong , Yu Chuanhua 
Published: January 2023

BackgroundDepressive disorders have become an increasingly significant public health issue. This study is intended to show the trend of the incidence of depressive disorders in China, the United States, India and the world from 1990 to 2019, as well as the impact of age, period and cohort on it.MethodsExtracting incidence data from the Global Burden of Disease Study 2019, we determined trends in the age-standardized incidence rate (ASIR) using Joinpoint regression. An age-period-cohort analysis was implemented to describe the effects of age, period, and cohort, as well as the long-term tendencies.ResultsFrom 1990 to 2019, the ASIR of depressive disorders in China was lower than that in the United States; India is lower than the United States in the first 5 years, showing a downward trend. The incidence in India and the United States is higher than the global average. The ASIR of women in the three countries is higher than that of men. In China, the elderly, early period and people born around 1954 have a higher risk of depressive disorders. In the United States, young people born around 1999 have a higher risk of depressive disorders. India is similar to China.ConclusionFrom 1990 to 2019, the age effect of China as a whole increased, and the period became stable, and the cohort effect declined. The overall age and period effects of the United States reduced, while the cohort effect increased. The age effect in India increased, while the period and cohort effects decreased. Depressive disorders are becoming ever more serious worldwide, and we’d better take measures to reduce its incidence according to the cohort effect of each age group.
Media use degree and depression: A latent profile analysis from Chinese residents
Authors: Gong Fangmin , Yi Pei , Yu Lian , Fan Siyuan , Gao Guangze , Jin Yile , Zeng Leixiao , Li Yang , Ma Zheng Feei 
Published: January 2023

BackgroundPrevious studies have emphasized the media as an essential channel for understanding information about depression. However, they have not divided groups according to the degree of media use to study their differences in depression. Therefore, this study aims to explore the influence of media use on depression and the influencing factors of depression in people with different media use degrees.MethodsBased on seven items related to media use, a total of 11, 031 respondents were categorized by the frequency of media use using latent profile analysis (LPA). Secondly, multiple linear regression analyzes were conducted to analyze the effects of depression in people with different degrees of media use. Finally, factors influencing depression among people with different degrees of media use were explored separately.ResultsAll respondents were classified into three groups: media use low-frequency (9.7%), media use general (67.1%), and media use high-frequency (23.2%). Compared with media use general group, media use low-frequency (β = 0.019, p = 0.044) and media use high-frequency (β = 0.238, p &lt; 0.001) groups are significantly associated with depression. The factors influencing depression in the population differed between media use low-frequency, media use general, and media use high-frequency groups.ConclusionThe government and the appropriate departments should develop targeted strategies for improving the overall health status of people with different media use degrees.
The psychometric properties of the Varieties of Inner Speech Questionnaire-Revised in Hebrew
Authors: Sabag Tal , Zohar Ada H. , Kreiner Hamutal , Lev-Ari Lilac , Rabinowitz Dean 
Published: January 2023

IntroductionThe Varieties of Inner Speech Questionnaire-Revised (VISQ-R) is a self-report questionnaire designed to measure characteristics of inner speech. In the current study, we adapted and validated a Hebrew version of VISQ-R. Our first hypothesis was that Confirmatory Factor Analysis (CFA) of the Hebrew VISQ-R would confirm the five subscales replicating the factor structure of the original questionnaire. In addition, building on previous findings that inner speech is involved in tasks that require the executive functions we examined the relationship between VISQ-R and self-reported executive functions questionnaire (BRIEF-A). We hypothesized that correlations between subscales of the Hebrew VISQ-R would reveal covariance between BRIEF-A and some but not all inner speech subscales.Methods406 participants completed the Hebrew VISQ-R and 280 of them also completed the BRIEF-A.ResultsAs hypothesized, CFA confirmed the factor structure revealing the same 5 subscales reported in the original English version, with acceptable internal reliability. Partial support was found for the hypothesized correlations between VISQ-R and BRIEF-A, with covariance of executive functions with some subscales of inner speech (Evaluative, Other-People and Dialogic), and distinct variance with others (Condensed and Positive).DiscussionThese results indicate that the Hebrew version of the VISQ-R has good psychometric properties and that it can be used in future research. The implications concerning the contribution of inner speech for people with difficulties in executive functions are discussed.
Risk factors for college students’ online lending between different genders-A cross-sectional study in China
Authors: Zhang Yan , Luo Lun , Li Pan , Xu Yun , Chen Zi 
Published: January 2023

BackgroundOnline lending on campus is given more attention by researchers as its prominent adverse effects on students. The deficiencies of the previous studies on its psychological factors and intervention strategies were only based on qualitative research. Moreover, there is no study on gender differences. Therefore, our study aims to analyze the gender differences in psychological risk factors and give some practical suggestions for the intervention by quantitative methods.MethodThis is a cross-sectional survey among medical college students in Chengdu. A total of 984 effective questionnaires were collected. The questionnaire includes demographic data, monthly expenses, self-evaluation for three central psychology causing online lending based on empiricism (conformity, comparison, and hedonism), and three psychological assessment instruments (the Chinese version of the Satisfaction with Life Scale, Egna Minnen av Barndoms Uppfostran, and 144-item version of Temperament and Character Inventory). T-test/χ2-test and Binary logistic regression were used to analyze the gender differences in variables and the risk factors of online lending for males and females, respectively.ResultsThe utilization rate of online lending exhibited a significant gender difference (p &lt; 0.001). In addition, there were gender differences in the scores on SWLS and some subscales of C-EMBU and TCI-144. The risk factors for males’ were family members using online lending (OR = 5.527, 95% CI = 1.784–17.125) and lower scores on HA (OR = 0.938, 95% CI = 0.888–0.990). The risk factors for females’ online lending were family members using online lending (OR = 2.288, 95% CI = 1.201–4.362), hedonism (OR = 5.913, 95% CI = 1.327–26.341), and higher scores on mother’s punishment (OR = 1.099, 95% CI = 1.007–1.199).ConclusionThe utilization rate of online lending in males was significantly higher than in females. More attention should be paid to gender differences and the impact of family members’ using online lending on students when intervening in online lending.
The applicability and efficacy of Micro-Video Psychological Training Camp in groups with mild to moderate symptoms of depression and anxiety: A prospective and randomized controlled trial protocol
Authors: Zhao Wenqing , Chen Shuangyi , Hu Jun , Zhou Qing , Tao Jing , Gao Rui , Zhang Jie , Su Shanshan , Wang Yuan , Su Yousong , Peng Yihua , Wu Yanru , Fan Qing , Zhang Weibo , Jiang Wenhui , Cai Jun , Qiu Jianyin 
Published: January 2023

BackgroundMental health is a global issue requiring global attention. Depression and anxiety are two of the most common mental disorders (CMDs) and are characterized by high incidence and high comorbidity. In recent years, the prolonged COVID-19 pandemic and exacerbated social instability have posed significant challenges to the mental resilience and mental health outcomes of the global population. Now more than ever, with an increase in mental health needs, it has become even more crucial to find an effective solution to provide universal mental healthcare. Psychotherapy is of vital importance for those coping with symptoms of depression and anxiety and is used to enhance mental resilience. However, such therapy can be difficult to access in reality. In this context, the Micro-Video Psychological Training Camp (MVPTC) platform will be developed.ObjectivesAs an online self-help platform for psychological intervention, the MVPTC platform was developed for those who suffer from mild to moderate symptoms of depression and/or anxiety and is tasked with the goal of reducing depressive and anxious symptoms while improving mental resilience. Thus, this study will be carried out to verify its efficacy and applicability.MethodsIn this parallel-group, randomized controlled trial, a total of 200 mild to moderately depressed and/or anxious adults seeking self-help will be randomly recruited and assigned to either the micro-video psychological intervention group or the wait list control group. Online measurements by self-assessment will be taken at baseline, post-intervention, 1-month, and 3-month follow-up.ResultsThe primary results will involve symptoms of depression and anxiety. The secondary results will involve mental resilience. An analysis will be conducted based on the intention-to-treat principle.DiscussionThis trial will examine whether the MVPTC platform for the relief of symptoms and the enhancement of resilience in a population screened for depression and anxiety symptoms proves effective and applicable. Large-scale resilience enhancement may benefit public mental health in terms of preventive interventions, managing depressive and anxiety symptoms, and promoting mental health. With the MVPTC-based method being applied, a brief, efficient, and structured intervention model can potentially be established, having the potential to provide necessary and accessible mental support for an extensive target group.Clinical trial registrationhttp://www.chictr.org.cn/, identifier ChiCTR2100043725.
Case report and literature review: Giant retroperitoneal cystic lymphangioma
Authors: Su Tieshan , Li Chaoyuan , Song Bin , Song Defeng , Feng Ye 
Published: January 2023

BackgroundCystic lymphangioma is a rare benign tumor of the lymphatic system, which is most commonly observed in the neck, head and armpit.Less than 5% of lymphangiomas occur in the abdominal cavity and even less in the retroperitoneum.Case descriptionA 65-year-old male patient was diagnosed with an “abdominal mass that had persisted for 1 year, accompanied by abdominal pain, abdominal distension and dyspnea for 7 days”. After abdominal computerd tomography, a giant multilobed abdominal lymphangioma was suspected, which squeezed the intestinal canal and was closely related to the inferior vena cava. The patient underwent an exploratory laparotomy, during which, it was found that the tumor formed extensive adhesions to the transverse colon, small intestine and pelvic wall, and enveloped the abdominal aorta, superior mesenteric artery, inferior mesenteric artery and inferior vena cava to varying degrees. It was diffcult to remove the cyst completely. Postoperative pathology confirmed the diagnosis of retroperitoneal cystic lymphangioma. The patient recovered well after the operation, was eating normally by 5 days postoperatively,and was discharged 10 days postoperatively.The patient was followed up 1 month after postoperatively and no evidence of recurrence was observed.ConclusionIn this case, we report a patient with giant retroperitoneal cystic lymphangioma who underwent exploratory laparotomy combined with preoperative abdominal computerd tomography and acute abdominal pain, abdominal distension and dyspnea. Because of the large volume of the tumor and its close relationship with the superior mesenteric artery and other blood vessels, the surgeon used scissors to separate the tumor sharply and removed the whole tumor completely.
Periodontal structures in horses with pituitary pars intermedia dysfunction: A histological evaluation
Authors: Zapf Anne Maria , Fey Kerstin , Büttner Kathrin , Gröf Manuela , Staszyk Carsten 
Published: January 2023

IntroductionPituitary pars intermedia dysfunction (PPID) and dental disorders are of major concern in horses older than 15 years. Although PPID in geriatric horses and dental disorders in all age groups are well described, a connection between this endocrine disease and pathological changes in equine dental structures has not yet been investigated. In humans, periodontitis is considered to be a complication of systemic diseases like diabetes mellitus type 2, obesity and various conditions leading to an impaired immune response. In PPID, cross links to insulin and immune dysregulations are proven. The aim of this study was to compare histological findings of the gingiva and the sub gingival periodontal ligament of PPID affected horses with control horses.MethodsIn a case-control morphometric descriptive study, 145 dental locations of 10 PPID affected horses (27.3 ± 2.06 years) were compared with 147 dental locations of 10 controls (21.4 ± 4.12 years). Histological parameters were leukocyte infiltration, keratinization of gingival epithelium, blood vessel supply of the periodontium and structure of cementum.ResultsThe distribution and localization of gingival leukocyte infiltrations (LI) in PPID affected horses was more often multifocal to coalescing (p = 0.002) and reached into deeper parts of the periodontium, sometimes down to the sub gingival periodontal ligament (PDL). Aged animals of both groups showed higher prevalence (PPID: OR 1.66; controls: OR 1.15) for severe leukocyte infiltration in the PDL. PPID was not significantly associated with increased LI. The cementum bordering the soft tissue in interdental locations showed four times more irregularities in PPID affected horses than in controls which predisposes for interdental food impaction and periodontal diseases.DiscussionIn summary, multifocal to coalescing leukocytes and irregular cementum are seen more often in PPID than in controls - however our findings mainly reflect an association of older age with periodontal disease.
PERANCANGAN MEJA TERAS DENGAN UNSUR HIAS ORNAMEN SURAKARTA
Authors: Rahmad Maylani Intan , Susila Dwi Agus 
Published: January 2023

Mebel kayu berukir adalah karya seni rupa tiga dimensi pada umumnya menggunakan material kayu yang sudah dibentuksedemikian rupa sehingga menjadi perabot untuk menunjang kegiatan manusia. Membuat desain mebel diperlukan persyaratan dan prinsip yang berorientasi pada seluruh anatomi dan ukuran manusia, keadaan jasmani, dalarn bergerak, bersikap dan tuntutan selera manusia. Dan perlu pemikiran konseptual agar desain dapat memenuhi permintaan pemakainya.