bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-site intervention using influencers to communicate about syringe service programmes
Authors: Bonnevie Erika , Dunn Silesky Melissa , Goldbarg Jaclyn , Gudmundsen Caitlyn , Fields Megan , Smyser Joe 
Published: September 2023

Introduction: In the USA, syringe services programmes (SSPs) provide a range of harm reduction services and have numerous benefits for communities. However, stigma, misconceptions about SSPs and changing policies/legislation remain a challenge to effective implementation. This study reviews the implementation of two digital interventions, Appalachian Influence and Shared Influence, which used social media influencers and digital volunteers to communicate positive information about harm reduction and SSPs. Methods: The intervention was designed to deliver accurate and supportive messaging in locally relevant and meaningful ways. Messaging was informed by interviews with subject matter experts and community organisations, and was integrated into prompts used by local influencers (paid individuals with more than 1,000 followers) and digital volunteers (unpaid individuals with no following requirement, who joined the project independently). Results: In the first 6 months of implementation, Appalachian Influence and Shared Influence engaged a total of 9,014 individuals, 236 of whom were paid influencers and 8,778 of whom were digital volunteers. Paid influencer posts achieved a total of 868,943 impressions, 42,432 engagements and 1,567 comments. Comments on paid influencer posts were overwhelmingly positive, with 87.4% positive and 0.8% negative. Interviews showed the importance of understanding local realities, leading with compassion and emphasising the ‘human’ aspects of dependency and addiction in messaging. Conclusion: This study shows the potential to implement an influencer-led social media intervention to reach people with authentic and compassionate messaging about harm reduction and SSPs. Future research should examine intervention effectiveness and how this approach can be applied to other stigmatised topics.
A Comprehensive Examination of the Contaminants in Drinking Water in Public Schools in California, 2017-2022
Authors: Garvey Kelly A. , Edwards Marc A. , Blacker Lauren S. , Hecht Christina E. , Parks Jeffrey L. , Patel Anisha I. 
Published: September 2023

Objectives: Reports of unsafe school drinking water in the United States highlight the importance of ensuring school water is safe for consumption. Our objectives were to describe (1) results from our recent school drinking water sampling of 5 common contaminants, (2) school-level factors associated with exceedances of various water quality standards, and (3) recommendations. Methods: We collected and analyzed drinking water samples from at least 3 sources in 83 schools from a representative sample of California public schools from 2017 through 2022. We used multivariate logistic regression to examine school-level factors associated with lead in drinking water exceedances at the American Academy of Pediatrics (AAP) recommendation level (1 part per billion [ppb]) and state action-level exceedances of other contaminants (lead, copper, arsenic, nitrate, and hexavalent chromium). Results: No schools had state action-level violations for arsenic or nitrate; however, 4% had ≥1 tap that exceeded either the proposed 10 ppb action level for hexavalent chromium or the 1300 ppb action level for copper. Of first-draw lead samples, 4% of schools had ≥1 tap that exceeded the California action level of 15 ppb, 18% exceeded the US Food and Drug Administration (FDA) bottled water standard of 5 ppb, and 75% exceeded the AAP 1 ppb recommendation. After turning on the tap and flushing water for 45 seconds, 2%, 10%, and 33% of schools exceeded the same standards, respectively. We found no significant differences in demographic characteristics between schools with and without FDA or AAP exceedances. Conclusions: Enforcing stricter lead action levels (<5 ppb) will markedly increase remediation costs. Continued sampling, testing, and remediation efforts are necessary to ensure drinking water meets safety standards in US schools.
Bifurcation and stability analysis of a high-speed rail vehicle with active yaw dampers
Authors: Guo Jinying , Shi Huailong , Zeng Jing 
Published: September 2023

Active yaw dampers (AYDs) show promise in addressing the carbody and bogie hunting issues of high-speed rail vehicles. However, the bifurcation behaviour under active control and the control law for hunting instability still require investigation. This study presents a comprehensive description of the linear control law, which can be simplified to various schemes, including skyhook damping, groundhook stiffness, modal, and blended schemes. The bifurcation behaviour under active control was analysed using a simplified lateral-dynamics-intended seven DOFs vehicle model and verified using a 3D full DOFs model in SIMPACK. Besides the well-known Hopf bifurcation, results also revealed a branching point (BP) and two new stable asymmetric equilibria. Although the asymmetric equilibria born through BP are stable, BP bifurcation should still be avoided for wheel flange contact and derailment concerns. Possible control laws are explored for two hunting scenarios: carbody hunting and bogie hunting. For carbody hunting cases, the control force can be either a linear function of bogie yaw displacement or a linear weighting function of bogie lateral and carbody roll velocity. The dominant frequency of the actuated force falls below 2 Hz, with a peak of 1.6 kN, and the allowable time delay is 70 ms. For bogie hunting cases, the control force can be a linear function of either bogie yaw displacement or velocity. In other words, both the groundhook stiffness and damping strategy are applicable. However, the actuated force contains several relatively high-frequency components (6∼13 Hz), which poses challenges to the control system and actuators, and the allowable time delay is relatively small.
The Intergroup Value Protection Model: A Theoretically Integrative and Dynamic Approach to Intergroup Conflict Escalation in Democratic Societies
Authors: van Zomeren Martijn , d’Amore Chantal , Pauls Inga Lisa , Shuman Eric , Leal Ana 
Published: September 2023

Scientific Abstract We review social-psychological evidence for a theoretically integrative and dynamic model of intergroup conflict escalation within democratic societies. Viewing individuals as social regulators who protect their social embeddedness (e.g., in their group or in society), the intergroup value protection model (IVPM) integrates key insights and concepts from moral and group psychology (e.g., group identification, outrage, moralization, protest) into a functional intergroup value protection process. The model assumes that social regulators are continuously looking for information diagnostic of the outgroup’s intentions to terminate the relationship with the ingroup, and that their specific cognitive interpretations of an outgroup’s action (i.e., as a violation of ingroup or shared values) trigger this process. The visible value-protective responses of one group can trigger the other group’s value-protective responses, thus dynamically increasing chances of conflict escalation. We discuss scientific implications of integrating moral and group psychology and practical challenges for managing intergroup conflict within democratic societies. Public Abstract The 2021 Capitol Hill attack exemplifies a major “trigger event” for different groups to protect their values within a democratic society. Which specific perceptions generate such a triggering event, which value-protective responses does it trigger, and do such responses escalate intergroup conflict? We offer the intergroup value protection model to analyze the moral and group psychology of intergroup conflict escalation in democratic societies. It predicts that when group members cognitively interpret another group’s actions as violating ingroup or shared values, this triggers the intergroup value protection process (e.g., increased ingroup identification, outrage, moralization, social protest). When such value-protective responses are visible to the outgroup, this can in turn constitute a trigger event for them to protect their values, thus increasing chances of intergroup conflict escalation. We discuss scientific implications and practical challenges for managing intergroup value conflict in democratic societies, including fears of societal breakdown and scope for social change.
Hip reconstruction in cerebral palsy: Lessons from a single center and 137 hips
Authors: Ayub Anoushka , Graff Christy , Horvat Lajos Maurovich , Maizen Claudia 
Published: September 2023

Background: This large, retrospective, single-center study aimed to compare the outcomes of unilateral hip reconstruction and bilateral hip reconstruction in children with non-ambulatory cerebral palsy and ascertain risk factors for recurrent instability and reoperation. Method: We performed a retrospective review of 137 hip reconstructions performed for patients with cerebral palsy. Preoperative and postoperative clinical and radiological parameters were documented, including hip migration percentage, acetabular index, the Gross Motor Function Classification System, the Melbourne Cerebral Palsy Hip Classification System, hip abduction, and pelvic obliquity. Results: Overall, 49 patients underwent bilateral hip reconstruction, and 37 patients underwent unilateral hip reconstruction. In the unilateral hip reconstruction group, the reconstructed hip remained stable (with a migration percentage < 33%) in 59% of patients compared to 74.4% of the more affected hips in the bilateral hip reconstruction group (p = 0.02). Of the unreconstructed hip in the unilateral hip reconstruction group, 74.4% remained stable (with a migration percentage < 33%), compared to 78.8% of the less affected hips in the bilateral hip reconstruction group. A level pelvis was maintained at final follow-up in significantly more patients in the bilateral hip reconstruction group than the unilateral hip reconstruction group (p = 0.002). Further surgical intervention was performed in 41% of the unilateral hip reconstruction group, compared with 11.5% in the bilateral hip reconstruction group (p = 0.001). Surgery performed under the age of 8 years and not performing an acetabular osteotomy were found to be risk factors for recurrent instability in all groups. Conclusion: Our series suggests that in terms of recurrent instability after hip reconstruction in cerebral palsy, protective factors against this complication include bilateral hip reconstruction, hip reconstruction after 8 years of age, and the use of an acetabular osteotomy.
The emerging roles of SUMOylation in pulmonary diseases
Authors: Zheng Xuyang , Wang Lingqiao , Zhang Zhen , Tang Huifang 
Published: September 2023

AbstractSmall ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia (BDP), PPARγ in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health.
Metabolomic-genomic prediction can improve prediction accuracy of breeding values for malting quality traits in barley
Authors: Guo Xiangyu , Sarup Pernille , Jahoor Ahmed , Jensen Just , Christensen Ole F. 
Published: September 2023

Abstract
Background
Metabolomics measures an intermediate stage between genotype and phenotype, and may therefore be useful for breeding. Our objectives were to investigate genetic parameters and accuracies of predicted breeding values for malting quality (MQ) traits when integrating both genomic and metabolomic information. In total, 2430 plots of 562 malting spring barley lines from three years and two locations were included. Five MQ traits were measured in wort produced from each plot. Metabolomic features used were 24,018 nuclear magnetic resonance intensities measured on each wort sample. Methods for statistical analyses were genomic best linear unbiased prediction (GBLUP) and metabolomic-genomic best linear unbiased prediction (MGBLUP). Accuracies of predicted breeding values were compared using two cross-validation strategies: leave-one-year-out (LOYO) and leave-one-line-out (LOLO), and the increase in accuracy from the successive inclusion of first, metabolomic data on the lines in the validation population (VP), and second, both metabolomic data and phenotypes on the lines in the VP, was investigated using the linear regression (LR) method.

Results
For all traits, we saw that the metabolome-mediated heritability was substantial. Cross-validation results showed that, in general, prediction accuracies from MGBLUP and GBLUP were similar when phenotypes and metabolomic data were recorded on the same plots. Results from the LR method showed that for all traits, except one, accuracy of MGBLUP increased when including metabolomic data on the lines of the VP, and further increased when including also phenotypes. However, in general the increase in accuracy of MGBLUP when including both metabolomic data and phenotypes on lines of the VP was similar to the increase in accuracy of GBLUP when including phenotypes on the lines of the VP. Therefore, we found that, when metabolomic data were included on the lines of the VP, accuracies substantially increased for lines without phenotypic records, but they did not increase much when phenotypes were already known.

Conclusions
MGBLUP is a useful approach to combine phenotypic, genomic and metabolomic data for predicting breeding values for MQ traits. We believe that our results have significant implications for practical breeding of barley and potentially many other species.
Analysis of gut microbiota in chinese donkey in different regions using metagenomic sequencing
Authors: Guo Rong , Zhang Wei , Shen Wei , Zhang Guoliang , Xie Taifeng , Li Ling , Jinmei Jiacuo , Liu Yiduan , Kong Fanyong , Guo Baozhu , Li Benke , Sun Yujiang , Liu Shuqin 
Published: September 2023

Abstract
Background
Gut microbiota plays a significant role in host survival, health, and diseases; however, compared to other livestock, research on the gut microbiome of donkeys is limited.

Results
In this study, a total of 30 donkey samples of rectal contents from six regions, including Shigatse, Changdu, Yunnan, Xinjiang, Qinghai, and Dezhou, were collected for metagenomic sequencing. The results of the species annotation revealed that the dominant phyla were Firmicutes and Bacteroidetes, and the dominant genera were Bacteroides, unclassified_o_Clostridiales (short for Clostridiales) and unclassified_f_Lachnospiraceae (short for Lachnospiraceae). The dominant phyla, genera and key discriminators were Bacteroidetes, Clostridiales and Bacteroidetes in Tibet donkeys (Shigatse); Firmicutes, Clostridiales and Clostridiales in Tibet donkeys (Changdu); Firmicutes, Fibrobacter and Tenericutes in Qinghai donkeys; Firmicutes, Clostridiales and Negativicutes in Yunnan donkeys; Firmicutes, Fibrobacter and Fibrobacteres in Xinjiang donkeys; Firmicutes, Clostridiales and Firmicutes in Dezhou donkeys. In the functional annotation, it was mainly enriched in the glycolysis and gluconeogenesis of carbohydrate metabolism, and the abundance was the highest in Dezhou donkeys. These results combined with altitude correlation analysis demonstrated that donkeys in the Dezhou region exhibited strong glucose-conversion ability, those in the Shigatse region exhibited strong glucose metabolism and utilization ability, those in the Changdu region exhibited a strong microbial metabolic function, and those in the Xinjiang region exhibited the strongest ability to decompose cellulose and hemicellulose.

Conclusion
According to published literature, this is the first study to construct a dataset with multi-regional donkey breeds. Our study revealed the differences in the composition and function of gut microbes in donkeys from different geographic regions and environmental settings and is valuable for donkey gut microbiome research.
Identifying predictors of cognitive decline in long-term care: a scoping review
Authors: Arora Gaurav , Milani Christina , Tanuseputro Peter , Tang Patrick , Jeong Ahwon , Kobewka Daniel , Webber Colleen 
Published: September 2023

Abstract
Background
Cognitive impairment can cause social, emotional, and financial burdens on individuals, caregivers, and healthcare providers. This is especially important in settings such as long-term care (LTC) homes which largely consist of vulnerable older adults. Thus, the objective of this study is to review and summarize current research examining risk factors of cognitive decline in older adults within LTC.

Methods
This scoping review includes primary observational research studies assessing within-person change in cognition over time in LTC or equivalent settings in high resource countries. A mean participant age of ≥ 65 years was required. Searches were conducted in Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PyscInfo on June 27th, 2022 and included articles published during or after the year 2000. Title, abstract, and full-text screening was performed by two independent reviewers using Covidence. Specific predictors along with their associated relation with cognitive decline were extracted by a team of reviewers into a spreadsheet.

Results
Thirty-eight studies were included in this review. The mean sample size was 14 620. Eighty-seven unique predictors were examined in relation to cognitive decline. Dementia was the most studied predictor (examined by 9 of 38 studies), and the most conclusive, with eight of those studies identifying it as a risk factor for cognitive decline. Other predictors that were identified as risk factors included arterial stiffness (identified by 2 of 2 studies), physical frailty (2 of 2 studies), sub-syndromal delirium (2 of 2 studies), and undergoing the first wave of COVID-19 lockdowns (2 of 2 studies). ADL independence was the most conclusive protective factor (3 of 4 studies), followed by social engagement (2 of 3 studies). Many remaining predictors showed no association and/or conflicting results.

Conclusions
Dementia was the most common risk factor, while ADL independence was the most common protective factor associated with cognitive decline in LTC residents. This information can be used to stratify residents by risk severity and provide better personalized care for older adults through the targeted management of cognitive decline.
Empirical antibiotic treatment for community-acquired pneumonia and accuracy for Legionella pneumophila, Mycoplasma pneumoniae, and Clamydophila pneumoniae: a descriptive cross-sectional study of adult patients in the emergency department
Authors: Lorentzen Morten Hjarnø , Rosenvinge Flemming Schønning , Lassen Annmarie Touborg , Graumann Ole , Laursen Christian B. , Mogensen Christian Backer , Skjøt-Arkil Helene 
Published: September 2023

Abstract
Background
Many factors determine empirical antibiotic treatment of community-acquired pneumonia (CAP). We aimed to describe the empirical antibiotic treatment CAP patients with an acute hospital visit and to determine if the current treatment algorithm provided specific and sufficient coverage against Legionella pneumophila, Mycoplasma pneumoniae, and Clamydophila pneumoniae (LMC).

Methods
A descriptive cross-sectional, multicenter study of all adults with an acute hospital visit in the Region of Southern Denmark between January 2016 and March 2018 was performed. Using medical records, we retrospectively identified the empirical antibiotic treatment and the microbiological etiology for CAP patients. CAP patients who were prescribed antibiotics within 24 h of admission and with an identified bacterial pathogen were included. The prescribed empirical antibiotic treatment and its ability to provide specific and sufficient coverage against LMC pneumonia were determined.

Results
Of the 19,133 patients diagnosed with CAP, 1590 (8.3%) patients were included in this study. Piperacillin-tazobactam and Beta-lactamase sensitive penicillins were the most commonly prescribed empirical treatments, 515 (32%) and 388 (24%), respectively. Our analysis showed that 42 (37%, 95% CI: 28–47%) of 113 patients with LMC pneumonia were prescribed antibiotics with LMC coverage, and 42 (12%, 95% CI: 8–15%) of 364 patients prescribed antibiotics with LMC coverage had LMC pneumonia.

Conclusion
Piperacillin-tazobactam, a broad-spectrum antibiotic recommended for uncertain infectious focus, was the most frequent CAP treatment and prescribed to every third patient. In addition, the current empirical antibiotic treatment accuracy was low for LMC pneumonia. Therefore, future research should focus on faster diagnostic tools for identifying the infection focus and precise microbiological testing.