bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Imaging of Critical Coarctation of the Aorta: Impact on Surgical Approach and Outcomes
Authors: McVadon Deani H. , Zyblewski Sinai C. , Chowdhury Shahryar M. 
Published: June 2023

Abstract
Background: Computed tomographic angiography (CTA) has been increasingly used for the evaluation of infants with aortic arch hypoplasia and coarctation of the aorta. The goals of this study were to compare echocardiographic and CTA findings in critical coarctation of the aorta, to evaluate each modality’s influence on surgical approach for repair and determine if pre-operative measurements or surgical approach are associated with residual lesions/re-interventions.
Methods: This was a single center retrospective cohort study that included 85 neonates and infants who underwent repair of coarctation/arch hypoplasia by three months of age. Two groups were compared: patients with preoperative echocardiograms only and patients with both echocardiogram and CTA evaluations.
Results: 44 (52%) patients received an echocardiogram and CTA, and 41 (48%) patients received an echocardiogram only. Patients in the CTA + echo group had smaller mitral valve and ascending aorta measurements (p = 0.01). When comparing CTA to echocardiogram measurements, the aortic valve annulus, ascending aorta, proximal and distal transverse arch, and isthmus were smaller on echo (p < 0.01). A smaller aortic valve annulus and aortic root as well as thoracotomy approach were associated with residual gradients/re-intervention (p<0.01).
Conclusions: Our study found that patients who underwent CTA pre-operatively had smaller left sided structures. Aortic measurements were smaller on echocardiogram when compared to CTA. Smaller left sided structures proximal to the aortic arch and thoracotomy predicted the development of residual lesions/re-intervention. CTA is useful in the surgical planning for neonates with arch hypoplasia/coarctation and may help risk stratify for residual lesions/re-intervention.
Modelling the differences between ultra-rapid and final orbit products of GPS satellites using machine learning approaches
Authors: Gou Junyang , Rösch Christine , Shehaj Endrit , Chen Kangkang , Shahvandi Mostafa Kiani , Soja Benedikt , Rothacher Markus 
Published: June 2023

Abstract
The International GNSS Service analysis centers provide orbit products of GPS satellites with weekly, daily, and sub-daily latency. The most frequent ultra-rapid products, which include one day of orbits derived from observations and one day of orbit prediction, are vital for real-time applications. However, the predicted part of the ultra-rapid orbits is less accurate than the part covered by observations and has deviations of several decimetres with respect to the final products. In this study, we investigate the potential of applying machine learning (ML) and deep learning (DL) algorithms to enhance physics-based orbit predictions further. We employed multiple ML/DL algorithms and comprehensively compared the performances of different models. Since the prediction errors of the physics-based propagators accumulate with time and have sequential characteristics, specific sequential modelling algorithms, such as Long Short-Term Memory (LSTM), show superiority. Our approach shows promising results with average improvements of 47% in 3D RMS within the 24-hour prediction interval of the ultra-rapid products. In the end, we apply the orbits improved by LSTM to kinematic precise point positioning and demonstrate the benefits for geodetic applications. The accuracy of the station coordinates estimated based on these products is improved by 16% on average compared to those using ultra-rapid orbits.
Comparative analysis of the prebiotic effect of Fructooligosaccharides and Raffinose oligosaccharides on nutraceutical and sensory properties of soymilk fermented with mixed cultures of Lacticaseibacillus rhamnosus and Weissella confusa 30082b
Authors: Sasi Minnu , Kumar Sandeep , Tomar Govind Singh , Mishra Jigni , Arpitha  , Kaushik Parshant , S Vinayaka , Krishnan Veda , Rana Virendra Singh , Shakeel Najam , Saha Supradip , Dahuja Anil 
Published: June 2023

Abstract
High potential is attributed to the concomitant use of probiotics and prebiotics in a single food product, called "synbiotics," where the prebiotic component distinctly favours the growth and activity of probiotic microbes. This study implemented a detailed comparison between the prebiotic effect of Fructooligosaccharides (FOS) and Raffinose Oligosaccharides (RFOs) on the viable count of bacteria, hydrolysis into monosaccharides for the biosynthesis of postbiotic Short Chain Fatty Acids and sensory attributes of soymilk fermented with 1% (v/v) mixed cultures of Lacticaseibacillus rhamnosus JCM 1136 and Weissella confusa 30082b. The highest viable count of 1.21×109 CFU/ml was observed in soymilk with 3%RFOs added as a prebiotic source compared with MRS broth with 3% RFOs (3.21×108) and 3%FOS (6.2 ×107 CFU/ml) when replaced against glucose in MRS broth. Raffinose and stachyose were extensively metabolised (4.75 and 1.28-fold decrease, respectively) in 3%RFOs supplemented with soymilk, and there was an increase in glucose, galactose, fructose (2.36,1.55, 2.76-fold respectively) in soymilk supplemented with 3% FOS. Synbiotic soymilk with 3%RFOs showed a 99-fold increase in methyl propionate, while the one supplemented with 3%FOS showed an increase in methyl butyrate. The highest acceptability was for soymilk fermented with 2%RFOs + 2%FOS + 2% Table sugar + 1% vanillin (7.87 ± 0.52) with high Mouth feel, product consistency, taste, and flavour. This study shows that simultaneous administration of soy with probiotic bacteria and prebiotic oligosaccharides like FOS and RFOs enhance the synergistic interaction between them, which up-graded the nutritional and sensory quality of synbiotic soymilk.
Valentino’s syndrome in acute pancreatitis female patient: A case report with literature review
Authors: Sarsono Michael Chandra , Pandapotan Roy Akur , Wahab Erwin Suryanegara 
Published: June 2023

Abstract
INTRODUCTION:
Valentino’s syndrome is an unusual right iliac fossa pain due to perforation of a duodenal peptic ulcer through the paracolic sulcus leading to local irritation. The aim of this study is to report a case of Valentino’s syndrome from acute pancreatitis with a brief literature report.
CASE PRESENTATION:
A 50-year-old lady presented with diffuse irradiated abdominal pain and swelling of about 6 h duration, associated with nausea, vomiting, and inability to flatus. There was positive upper abdominal and right iliac fossa tenderness. The abdominal computed tomography (CT) scan showed acute pancreatitis appearance with fat stranding and fluid collection from the peripancreatic to the right lower quadrant. Serum amylase and lipase were elevated. Therefore, the initial diagnoses were acute pancreatitis and appendicitis. Conservative management was done because of poor hemodynamics, laboratory work-up, and the lack of medical speciality to perform surgery. The patient was then transferred to another hospital with adequate facilities.
CONCLUSION
Valentino’s syndrome from acute pancreatitis is an extremely rare case, presented with vague symptoms, diagnosed by abdominal CT scan. Clinical diagnosis could be challenging for clinicians.
Improving secondary settling tanks performance by applying CFD models for design and operation
Authors: Dairi Sabri , Khoualdia Wassila , Mrad Dounia , Bouamrane Ali , Djebbar Yassine , Abida Habib 
Published: June 2023

Abstract

This study uses computational fluid dynamics (CFD) models for an improved performance of secondary settling tanks, taking as a case study the wastewater treatment plant (WWTP) of Souk-Ahras City, Northeastern Algeria. Unlike previous studies, which focused primarily on simulations of real-time clarifiers by independent measures, this study combines differentoperating criteria and geometric standards on clarifiers to estimate the ultimate capacity of secondary sedimentation tanks (SST). Numerical simulations were performed toassess the SST hydraulic performance under different conditions in order to (i) eliminate vortex zones; (ii) optimize the surface overflow rate (SOR) and predict sludge blanket height (SBH), and finally, (iii) estimate SST ultimate capacity. Based on the current configuration of the SST of Souk-Ahras WWTP, its hydraulic treatment capacity was found to be 49,000 m3/d. The results obtained, which were validated by field observations, showed that optimizing the different parameters yields a significantly improved SST performance. Furthermore, the tests consideredwere shown to be satisfactorily correlated with SOR. Validation using the receiver operating characteristic (ROC) curve analysis yielded anarea under curve (AUC) value of 90%, implying thereby a reasonably good performance. Indeed, optimization resulted in increased solidremoval efficiency and increased SOR to 1.4 m.h−1 (compared to 0.8 m.h−1 in literature) without overflow beyond the SBH.
Groundwater potential zonation in the Siwalik of the Kankai River Basin, Eastern Nepal
Authors: Silwal Champak Babu , Nepal Mukesh , Pathak Dinesh , Karkee Balram , Dahal Kiran , Acharya Samir 
Published: June 2023

Abstract

For the globally degrading groundwater resources in terms of quantity and quality, proper assessment and management become crucial for their sustainable use. This study aims to delineate the groundwater potential zones using an integrated approach of geographic information system (GIS) and the Analytical Hierarchy Process (AHP) in the Siwalik of the Kankai River Basin, Eastern Nepal. Different thematic layers like hydrogeomorphology, land use/land cover, lithology, slope, topographic wetness index, drainage density, normalized difference vegetation index, lineament density, and aspect were prepared and processed with suitable weights on Saaty's scale. The delineated groundwater potential zones in the study area were categorized as low, moderate, and high. The results showed that approximately 49.38% (130.85 km2) of the total study area has a low potential for groundwater. The moderate zone includes approximately 35.5% (94.07 km2) and the high potential zone includes only 15.05% (39.88 km2) of the area. The potential map was validated with a 70.6% prediction rate using the spatial distribution of the springs in the area. The analysis shows that hydrogeomorphology, LULC, and lithology have a significant control on the occurrences of groundwater. The study signifies the scarcity of groundwater resources, which needs a better management plan and strategies for sustainable use.
Synthesis and Biological Study of 4-Aminopyridine-Peptide Derivatives Designed for the Treatment of Neurodegenerative Disorders
Authors: Vezenkov Lyubomir T. , Tsekova Daniela S. , Kostadinova Ivanka , Mihaylova Rositsa , Lozanov Valentin , Vassilev Nikolay G. , Danchev Nikolai , Tsakovska Ivanka , Pajeva Ilza 
Published: June 2023

Background:
Alzheimer’s disease (AD) and Multiple sclerosis (MS) lead to neurodegenerative
processes negatively affecting millions of people worldwide. Their treatment is still difficult and
practically incomplete. One of the most commonly used drugs against these neurodegenerative diseases
is 4-aminopyridine. However, its use is confined by the high toxicity.

Objectives:
The aim of this work is to obtain new peptide derivatives of 4-aminopyridine with decreased
toxicity compared to 4-aminopyridine.

Methods:
Synthesis was conducted in solution using a consecutive condensation approach. The new
derivatives were characterized by melting points, NMR, and Mass spectra. Important ADME (absorption,
distribution, metabolism, and excretion) properties have been studied in silico using
ACD/Percepta v.2020.2.0 software. Acute toxicity was determined in mice according to a Standard
protocol. All new derivatives were tested in vitro for cytotoxic activity in a panel of human (HEP-G2,
BV-173) and murine (NEURO 2A) tumor cell lines via a standard MTT-based colorimetric method.
β-secretase inhibitory activity was determined by applying the fluorescent method.

Results:
New derivatives of 4-aminopyridine containing analogues of the β-secretase inhibitory peptide
(Boc-Val-Asn-Leu-Ala-OH) were obtained. The in vivo toxicity of the tested compounds was
found to be as high as 1500 mg/kg. Cell toxicity screening against tumor cell lines of different origins
showed negligible growth-inhibitory effects of all investigated 4-aminopyridine analogues.

Conclusion:
Synthesis of new peptide derivatives of 4-aminopyridine is reported. Acute toxicity studies
revealed a ca. 150 times lower toxicity of the new compounds as compared to 4-aminopyridine
that may be ascribed to their peptide fragment.
New Relations between Zagreb Indices and Omega Invariant
Authors: Gunes Aysun Yurttas 
Published: June 2023

Abstract:
In this work, we studied the problem of determining the values of the Zagreb indices of all the realizations of a given degree sequence.

Methods:
We first obtained some new relations between the first and second Zagreb indices and the forgotten index sometimes called the third Zagreb index. These relations also include the triangular numbers, order, size, and the biggest vertex degree of a given graph. As the first Zagreb index and the forgotten index of all the realizations of a given degree sequence are fixed, we concentrated on the values of the second Zagreb index and studied several properties including the effect of vertex addition.

Results:
In our calculations, we make use of a new graph invariant, called omega invariant, to reach nu-merical and topological values claimed in the theorems. This invariant is closely related to Euler charac-teristic and the cyclomatic number of graphs.

Conclusion:
Therefore this invariant is used in the calculation of some parameters of the molecular structure under review in terms of vertex degrees, eccentricity, and distance.
Review of Perspectives on Increasing Demand for "Cardamom Tincture Aromatic" in the Global Market
Authors: Singh Sonia , Goswami Manisha , Agrawal Nitin 
Published: June 2023

Abstract:
Cardamom belongs to the family Zingiberaceae and is indigenous to India and Malesia.
The crude drug has potential pharmacological applications such as antioxidant, analgesic, antibacterial
antioxidant, and anti-inflammatory activities. Cardamom also contains bioactive constituents,
including terpenoids, flavonoids, carbohydrates, essential oils, and carotenoids. The demand for
herbal medicines has increased in most emerging nations, and their supply has steadily grown
worldwide. Around 80% of people worldwide use herbal medicines to treat their illnesses. There are
many dosage forms for herbal products, including tinctures, powders, liniments, lotions, capsules,
balms, syrups, and tablets. "Herbal tincture" refers to concentrated herbal extracts with ethanol generally
functioning as the solvent. Cardamom can be used as a tincture to extract its beneficial compounds
and create a concentrated liquid form for various purposes. These are widely used as folk
medicines and are even well-known in many medical systems, including Ayurveda and homeopathy.
There are numerous herbal tinctures on the market, including those of tulsi, compound cardamom,
and ginger. These preparations are simple to use and store. The current manuscript discusses
several tincture preparation techniques, focusing on cardamom tincture and stability conditions, a
market overview, and a few patents.

:
This article briefly overviews the global trading markets for herbal tinctures, particularly cardamom
tinctures. Even the paper has explored the general information of cardamom and a market overview
of the herbal tinctures.
Deshidratación de lodo residual a escala piloto en un secador convectivo rotacional, Caso:Planta de tratamiento de aguas santa clara, provincia de Lima, Perú
Authors: Natividad Marin Leynard , Gil Villanueva Alfonso 
Published: June 2023

Esta investigación tuvo como finalidad disminuir la humedad y el contenido de patógenos presentes en el lodo residual de la Planta de Tratamiento de Aguas Residuales de Santa Clara. Esto permitiría reducir costos de transporte del lodo al relleno sanitario y su posible reutilización como fertilizante. La deshidratación a escala piloto se realizó mediante un proceso constituido por un secador convectivo de rotación continua, tanque de agitación, tornillo de alimentación, sistema de calentamiento de aire, colector ciclónico y un lavador de gases. El efecto de la temperatura (120°C, 150°C y 200°C) y el tiempo de permanencia del lodo dentro del tambor de secado (20, 40, y 60 minutos) fueron estudiados. El lodo húmedo inicial, conteniendo 85.90%, 9.17% y 4.93% en agua, sólidos suspendidos volátiles y sólidos suspendidos no volátiles respectivamente, alcanzó una humedad mínima promedio de 17.74% a una temperatura de 200°C y 60 minutos de permanencia. No se detectó en la muestra de lodo inicial Huevos de Helmintos, pero si un alto contenido de Escherichia Coli (4×105 NMP/1g ST a 1.6×107 NMP/1g ST), siendo necesario adicionar para estabilizarla a pH alrededor de 12 durante la alimentación del lodo al secador. La caracterización del lodo deshidratación muestra que la alta concentración de nutrientes (N, P, C, etc.) indica ventajas como fertilizante, pero su alto contenido en metales sugiere mayor investigación si se pretende usarlo en el cultivo de alimentos.
Electrocardiogram Devices for Home Use: Technological and Clinical Scoping Review
Authors: Zepeda-Echavarria Alejandra , van de Leur Rutger R , van Sleuwen Meike , Hassink Rutger J , Wildbergh Thierry X , Doevendans Pieter A , Jaspers Joris , van Es René 
Published: June 2023

Background
Electrocardiograms (ECGs) are used by physicians to record, monitor, and diagnose the electrical activity of the heart. Recent technological advances have allowed ECG devices to move out of the clinic and into the home environment. There is a great variety of mobile ECG devices with the capabilities to be used in home environments.

Objective
This scoping review aimed to provide a comprehensive overview of the current landscape of mobile ECG devices, including the technology used, intended clinical use, and available clinical evidence.

Methods
We conducted a scoping review to identify studies concerning mobile ECG devices in the electronic database PubMed. Secondarily, an internet search was performed to identify other ECG devices available in the market. We summarized the devices’ technical information and usability characteristics based on manufacturer data such as datasheets and user manuals. For each device, we searched for clinical evidence on the capabilities to record heart disorders by performing individual searches in PubMed and ClinicalTrials.gov, as well as the Food and Drug Administration (FDA) 510(k) Premarket Notification and De Novo databases.

Results
From the PubMed database and internet search, we identified 58 ECG devices with available manufacturer information. Technical characteristics such as shape, number of electrodes, and signal processing influence the capabilities of the devices to record cardiac disorders. Of the 58 devices, only 26 (45%) had clinical evidence available regarding their ability to detect heart disorders such as rhythm disorders, more specifically atrial fibrillation.

Conclusions
ECG devices available in the market are mainly intended to be used for the detection of arrhythmias. No devices are intended to be used for the detection of other cardiac disorders. Technical and design characteristics influence the intended use of the devices and use environments. For mobile ECG devices to be intended to detect other cardiac disorders, challenges regarding signal processing and sensor characteristics should be solved to increase their detection capabilities. Devices recently released include the use of other sensors on ECG devices to increase their detection capabilities.
Improving the Quality of Postpartum Care in Ghana: Protocol for a Parallel Randomized Controlled Trial
Authors: Adams Yenupini Joyce , Agbenyo John Stephen 
Published: June 2023

Background
Although the postpartum period poses substantial risks and can result in significant maternal morbidity and mortality, postpartum care of the mother receives much less attention in transitional countries.

Objective
We describe the protocol for a randomized controlled trial to implement and evaluate a postpartum care delivery model titled Focused-PPC (Focused Postpartum Care).

Methods
Focused-PPC is an integrated group postpartum care model that meets the clinical care, education, and support needs of mothers up to 1 year after birth. The Focused-PPC intervention is a parallel randomized controlled trial with a total of 192 postpartum women at 4 health centers in Tamale, Ghana. Participants will be randomized into 1 of 2 trial arms at a 1:1 allocation ratio: (1) the control arm, which receives the standard postnatal care currently delivered in health facilities, or (2) the intervention arm, which receives the Focused-PPC model of care. Women enrolled in the intervention arm will receive postpartum clinical assessments and education for the first 6 weeks and will continue to receive education, measures of vital signs, and peer support for 12 months post partum during child welfare visits. Led by trained midwives, each postpartum group in the intervention arm will meet at 1-2 weeks, 6 weeks, and monthly thereafter for up to 1 year post partum, following the Ghana Health Service postnatal care schedule.

Results
The Focused-PPC guide, data collection tools, and audiovisual education materials were successfully developed and translated into the local language. We have enrolled and conducted baseline surveys for 192 women (sample size met) in the Focused-PPC trial who have been randomized into intervention and control arms. We have established a total of 12 Focused-PPC groups in the intervention arm, 3 groups from each site, all of which have sessions underway.

Conclusions
Focused-PPC has the potential to change the postpartum care delivery model in Ghana and other countries in sub-Saharan Africa and beyond.

Trial Registration
ClinicalTrials.gov NCT05280951; https://clinicaltrials.gov/study/NCT05280951

International Registered Report Identifier (IRRID)
DERR1-10.2196/47519
THE INFLUENCE OF AUGMENTED REALITY ON ONLINE USER EXPERIENCES
Authors: Radoičić Jovana , Vujović Sonja , Vujović Tanja 
Published: June 2023

The subject of this paper is the analysis of the impact of augmented reality on online user experiences. The analysis was performed on users’ experience with the Ikea Place App by IKEA. Users were surveyed through the User Experience Questionnaire (UEQ), through which the information about their online experiences related to the analyzed application was collected. The aim of this paper is to determine whether augmented reality and augmented reality applications complement the online user experience, based on the analysis of their user experience and experience related to the dimensions of the presented application. The intention is to contribute to the creation of the business and academic public’ interest in the concept of augmented reality as a model, which, by offering a ‘customized’ shopping experience, contributes to improving the level of consumer satisfaction.