bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of clinical significance and molecular characteristics of methionine metabolism and macrophage-related patterns in hepatocellular carcinoma based on machine learning
Authors: Wen Diguang , Wang Shuling , Yu Jiajian , Yu Ting , Liu Zuojin , Li Yue 
Published: July 2023

BACKGROUND: Increasing evidence has indicated that abnormal methionine metabolic activity and tumour-associated macrophage infiltration are correlated with hepatocarcinogenesis. However, the relationship between methionine metabolic activity and tumour-associated macrophage infiltration is unclear in hepatocellular carcinoma, and it contributes to the occurrence and clinical outcome of hepatocellular carcinoma (HCC). Thus, we systematically analysed the expression patterns of methionine metabolism and macrophage infiltration in hepatocellular carcinoma using bioinformatics and machine learning methods and constructed novel diagnostic and prognostic models of HCC. METHODS: In this study, we first mined the four largest HCC mRNA microarray datasets with patient clinical data in the GEO database, including 880 tissue mRNA expression datasets. Using GSVA analysis and the CIBERSORT and EPIC algorithms, we quantified the methionine metabolic activity and macrophage infiltration degree of each sample. WGCNA was used to identify the gene modules most related to methionine metabolism and tumour-associated macrophage infiltration in HCC. The KNN algorithm was used to cluster gene expression patterns in HCC. Random forest, logistic regression, Cox regression analysis and other algorithms were used to construct the diagnosis and prognosis model of HCC. The above bioinformatics analysis results were also verified by independent datasets (TCGA-LIHC, ICGC-JP and CPTAC datasets) and immunohistochemical fluorescence based on our external HCC panel. Furthermore, we carried out pancancer analysis to verify the specificity of the above model and screened a wide range of drug candidates. RESULTS: We identified two methionine metabolism and macrophage infiltration expression patterns, and their prognoses were different in hepatocellular carcinoma. We constructed novel diagnostic and prognostic models of hepatocellular carcinoma with good diagnostic efficacy and differentiation ability. CONCLUSIONS: Methionine metabolism is closely related to tumour-associated macrophage infiltration in hepatocellular carcinoma and can help in the clinical diagnosis and prognosis of HCC.
Emergent Quantum Gravity
Authors: Bhattacharjee Deep 
Published: July 2023

The most common scenario regards to quantum gravity is how gravity can be quantized? This facilitates a peculiar problem of ultraviolet divergences that has been shown in [1] in Einstein – Hilbert action that from loop (2) onwards in the \(\Gamma_{k\longrightarrow\infty}^{\left(2\right)}\) where there are unperturbed actions where divergences are so nasty that one needs a correction and thus this has to be cut off using \(\Lambda\) .

The main focus of this paper is to negate the divergences by means of a concept called quantum clustering that arises out of geometric insertions in Branes where the leakage of gravity from our 4 – dimensional universe can be hypothesized to form a cluster action over co-dimensional branes that in a way act as a regulator to perform the recoiling actions developed in those higher dimensional branes with a large number of lower dimensional Brane being chaotic and makes a looping because of the recoil actions arises from the bifurcations of those intersecting Branes where the maximum concentration of graviton can be found making them free from divergences.
Кооперативне навчання математики та роль підручника в його реалізації
Authors: Васильєва Дарина , Букалов Лариса 
Published: July 2023

Здійснено аналіз досліджень про кооперативне навчання та його вплив на навчальні досягнення учнів, а також нормативної бази Нової української школи. Показано, що формуванню необхідних умінь та ставлень учнів у процесі навчання математики допомагає їх залученню до роботи в групі і парі. Розглянуто різні погляди науковців на кооперативне навчання та навчальне співробітництво. Наведені визначення, основні елементи кооперативного навчання та етапи його організації. З’ясовано, на основі опитування 220 учителів, стан упровадження кооперативного навчання математики в 5 класах Нової української школи, ставлення вчителів та учнів до такого навчання. Виявлено, що більшість учителів залучають учнів до кооперативного навчання під час традиційного навчання, але не залучають під час дистанційного навчання. Визначено частоту залучення учнів до такого виду навчання та час, що відводиться на нього. Описано ключові компетентності учнів, розвиток яких сприяє роботі в групах і парах та те, як це змінює атмосферу у класі. Зазначено, з якими труднощами стикаються вчителі у організації кооперативного навчання. Проаналізовано підручники математики для 5 класу і виявлено ті, що мають завдання для груп і пар учнів. Наведено приклади завдань, які доцільно увести до підручників з математики 5‒6 класів для стимуляції впровадження кооперативного навчання математики. Описані окремі технології, за допомогою яких можна організувати роботу учнів з цими завданнями.
Cell Cycle Synchronization of Primary Articular Chondrocytes Enhances Chondrogenesis
Authors: Subedar Omar Dawood , Chiu Loraine L. Y. , Waldman Stephen 
Published: July 2023

<p><strong>Objective</strong></p>
<p>Although tissue engineering is a promising option for articular cartilage repair, it has been challenging to generate functional cartilaginous tissue. While the synthetic response of chondrocytes can be influenced by various means, most approaches treat chondrocytes as a homogeneous population that would respond similarly. However, isolated cells heterogeneously progress through the cell cycle, which can affect macromolecular biosynthesis. As it is possible to synchronize cells within discrete cell cycle phases, the purpose of this study was to investigate the effects of cell cycle synchronization on the chondrogenic potential of primary articular chondrocytes.</p>
<p><strong>Design</strong></p>
<p>Different methods of cell synchronization (serum starvation, thymidine, nocodazole, aphidicolin, and RO-3306) were tested for their ability to synchronize primary articular chondrocytes during the process of cell isolation. Cells (unsynchronized and synchronized) were then encapsulated in alginate gels, cultured for 4 weeks, and analyzed for their structural and biochemical properties.</p>
<p><strong>Results</strong></p>
<p>The double-thymidine method yielded the highest level of cell purity, with cells synchronized in S phase. While the cells started to lose synchronization after 24 hours, tissue constructs developed from initially S phase synchronized cells had significantly higher glycosaminoglycan and collagen II amounts than those developed using unsynchronized cells.</p>
<p>Conclusions</p>
<p>Initial synchronization led to long-term changes in cartilaginous tissue formation. This effect was postulated to be due to the rapid auto-induction of TGF-βs by actively dividing S phase cells, thereby stimulating chondrogenesis. Cell synchronization methods may also be applied in conjunction with redifferentiation methods to improve the chondrogenic potential of dedifferentiated or diseased chondrocytes. </p>
Book Review: Derr, Jennifer L. 2019. The Lived Nile: Environment, Disease, and Material Colonial Economy in Egypt. Stanford, CA: Stanford University Press.
Authors: Gore Christopher 
Published: July 2023

<p> In 1999, the Nile Basin Initiative (NBI) was established to manage and develop the Nile Basin waters. The NBI has fostered and facilitated dialogue among its ten member states since its inception, but tension over the use of the Nile waters remains high. Many countries continue to build large hydroelectric projects in the basin without the agreement of other countries. Egypt has argued that it has a right to a continuous volume of water and has threatened to use military force to guarantee that right. Other factors, particularly climate change, are also undermining the volume and predictability of water supplies in the basin. Access to basin waters is especially in demand to improve national and regional electricity supplies and irrigation and, ultimately, to transform and improve the quality of life of basin residents. But how do these regional and national interventions manifest at the individual and community levels? How do citizens and communities, willingly or not, become subjected to these transformations in their everyday lives? The Lived Nile provides an enthralling and critical historical examination of these questions. </p>
A Historical Review of Medical Robotic Platforms
Authors: Ginoya Tirth , Maddahi Yaser , Zareinia Kourosh 
Published: July 2023

<p>This paper provides a brief history of medical robotic systems. Since the first use of robots in medical procedures, there have been countless companies competing to developed robotic systems in hopes to dominate a field. Many companies have succeeded, and many have failed. This review paper shows the timeline history of some of the old and most successful medical robots and new robotic systems. As the patents of the most successful system, i.e., Da Vinci® Surgical System, have expired or are expiring soon, this paper can provide some insights for new designers and manufacturers to explore new opportunities in this field. </p>
“You’ve Just Cursed Us”: Precarity, Austerity and Worker’s Participation in the Non-Profit Social Services
Authors: Cunningham Ian , Baines Donna , Shields John 
Published: July 2023

<p>Drawing on qualitative interview data from two case studies of non-profit social service agencies in Ontario, Canada, this article explores the impacts of austerity and precarity on worker's participation in the non-profit social service workplace. The article reveals that market-embracing austerity is driving the erosion of workplace participation, both in terms of the level of control workers exercise over their day-to-day task and representative security. In the latter case, this includes union and non-union forms of representation. Workers in each organization exhibited efforts to resist the continuing undermining of their terms and conditions, but an increasingly hostile and assertive management facing pressure to cut costs was less likely to accede to worker demands. </p>
Massage Effleurage terhadap Adaptasi Kecemasan Primigravida
Authors: Masita Purmata Putri  , Fatma Jama  , Munir Nur Wahyuni 
Published: July 2023

Effleurage merupakan teknik pijatan dengan menggunakan telapak jari tangan dengan pola gerakan melingkar di beberapa bagian tubuh atau usapan sepanjang punggung dan ekstremitas. Penelitian ini bertujuan untuk mengetahui pengaruh Massage effleurage terhadap adaptasi tingkat kecemasan persalinan kala 1 fase aktif pada primigravida di RS Bersalin Masyita. Jenis penelitian yang di gunakan adalah experiment dengan desain pre eksperimental pendekatan one group prestest design karena akan membandingkan keadaan sebelum dilakukan dengan setelah dilakukan perlakuan. Sampel dalam penelitian ini adalah seluruh ibu bersalin prigravida sejumah 30 responden. Uji hubungan dilakukan dengan menggunakan uji paired sampel t testdengan tingkat kemaknaan (α) 0.05. Hasil uji paired sampel t testp=0.000, yang berarti nilai p lebih kecil dari nilai (α) 0.05, dengan demikian H0 ditolak dan Ha diterima. Interpretasi adanya Pengaruh Massage effleurage terhadapadaptasi tingkat kecemasan persalinan kala 1 fase aktif. Dengan penelitian ini dapat disimpulkan bahwa Mengatasi kecemasan peralinan kala 1 fae aktif, dapat dilakukan dengan melakukan cara – cara non farmakologi seperti massage contohnya dengan pemberian massage efflaurage, tanpa harus mengonsumsi obat. Untuk itu, maka diharapkan tenaga medis dapat memberikan penyuluhan kepada ibu hamil mengenai proses persalinan dan solusi yang dapat mengurangi kecemasan ibu Primigravida dalam menghadapi proses persalinan
Strategi Kepala Sekolah dalam Meningkatkan Kreativitas Guru di TK At-Tiin Kampar
Authors: Sufi Wasiah , Efastri Sean Marta 
Published: July 2023

Penelitian ini dilakukan dengan tujuan untuk mengetahui Strategi Kepala Sekolah dalam Mengembangkan Kreativitas Guru Mengajar di TK AT-TIIN Kampar. Peneltian ini dilakukan dengan metode penelitian Kuantitatif Deskriptif. Sampel pada penelitian ini adalah seluruh Guru yang ada di Gugus. Teknik pengambilan sampel menggunakan teknik total sampling dengan jumlah responden sebanyak 30 orang guru. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah lembar angket. Berdasarkan hasil penelitian didapatkan skor rata-rata 89,85% sehingga Strategi Kepala Sekolah dalam Mengembangkan Kreativitas Guru Mengajar di TK AT-TIIN Kampar masuk kedalam kategori sangat baik.
Persamaan linier Tinggi Bukaan Pintu Air Terhadap Kecepatan Aliran dengan Kedalaman Basah di saluran irigasi berbasis IoT Desa Sukoanyar
Authors: Norma Soraya , Noerhayati Eko , Suprapto Bambang , Rizal A’rofi Muhammad 
Published: July 2023

Pengaturan air irigasi penting untuk diperhatikan supaya pemanfaatan pintu air dapat efisien dan optimal yang bisa berdampak air boros atau malah kekurangan saat digunakan . Untuk mengatur Untuk mengukur bukaan pintu air dapat pada penelitian kali ini menggunakan teknologi berbasis Internet of Things (IoT). Diharapakan dengan teknologi ini bisa membantu para petani untuk mengoptimalkan kontrol air pada saluran irigasi dan sistem tanam. Penelitian ini membahas tentang hubungan secara matematis antara tinggi pintu air irigasi berbasis Internet of Things terhadap hidrolika aliran pada saluran irigasi Desa Sukoanyar Kecamatan Pakis dengan tinggi bukaan pintu yang berbeda dengan masing-masing tinggi bukaan pintu terdapat 6 titik, 4 titik berada sebelum pintu dan 2 titik setelah pintu. Data yang diproses dalam penelitian ini adalah data geometri dan data topografi saluran, dimensi pintu air, dan kecepatan aliran air. Tahapan awal dalam analisa adalah menghitung nilai geometri saluran, kemudian mengolah nilai kecepatan aliran pada setiap hasil percobaan. Untuk mendapatkan data kecepatan aliran menggunakan metode langsung dengan menggunakan alat current meter yang dilakukan dalam lima kali percobaan pada setiap titik.. Hasil dari penelitian ini didapatkan bahwa tinggi bukaan pintu air irigasi (IoT) berpengaruh terhadap berubahnya nilai dinamika saluran dengan analisa matematik persamaan nonlinear.
Kampanye Moderasi Beragama di Era Digital Sebagai Upaya Preventif Millenial Mereduksi Kasus Intoleransi di Indonesia
Authors: Hardiyanto Sigit , Fahmi Khoirul , Wahyuni Wahyuni , Adhani Abrar , Pahlevi Hidayat Fadhil 
Published: July 2023

Problematika kasus intoleransi antar umat beragama dapat dilihat dari beberapa kasus, seperti pembakaran tempat ibadah di Tanjung Balai, penyerangan Klenteng di Kediri dan mobilisasi massa untuk memprotes mantan Gubernur DKI Jakarta, Basuki Tjahaja Purnama (BTP) yang merendahkan QS. Al-Maidah ayat 51 pada tahun 2017, kasus penistaan agama yang dilakukan oleh Pendeta Saifuddin Ibrahim terkait pernyataan menghapus 300 ayat Alquran dan beberapa kasus lainnya menggambarkan tren intoleransi yang semakin meluas di masyarakat Indonesia. Adapun tujuan dari penelitian ini adalah untuk mengetahui kampanye moderasi beragama di era digital sebagai upaya preventif millenial mereduksi kasus intoleransi di Indonesia. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kepustakaan bertujuan untuk mengumpulkan data dan informasi dengan melakukan telaah dari berbagai sumber baik dari Al-Quran, Hadits, buku ilmiah, jurnal, dokumen dan tulisan-tulisan lain sebagai pembanding dan penunjang yang digunakan untuk memperoleh data. Hasil penelitian ini menunjukkan bahwa kampanye moderasi beragama yang dilakukan oleh kaum milenial dapat dilakukan melalui dunia maya. Melalui aksi moderasi beragama di lapangan kemudian mengekspos kegiatan tersebut di media sosial, serta melakukan semarak kampanye moderasi beragama melalui podcast di Youtube dan Instagram serta beberapa media sosial lainnya, penggunaan theory agenda setting sebagai upaya kampanye moderasi beragama di era digital dapat menjadi solusi jitu tindakan preventif kasus intoleransi di Indonesia
KEPEMIMPINAN KESULTANAN BUTON DALAM PERSPEKTIF NILAI PODHAGA ̅KA PAMARINTA MAROMBUMO ZAMANI
Authors: Nurhayati  , Arsyad Armin , Suaib Eka , Kambo Gustiana A. 
Published: July 2023

Podhagāka Pamarinta Amarombumo Zamani adalah nilai-nilai kepemimpinan kesultanan Buton. Tujuan penelitian ini adalah untuk memahami dan mengimplementasikan nilai-nilai kepemimpinan lokal terhadap kepemimpinan modern, pada pemilihan dan pelaksanaan kepemimpinannya. Penelitian ini dipandang penting karena melihat fenomena dan dinamika demokrasi yang tercoreng oleh permainan money politik. Pemilihan pemimpin politik dan praktek kepemimpinan dewasa ini diwarnai dengan praktek jual beli suara, terjadi praktek transaksional baik pada pemilihan kepala daerah maupun pemilihan caleg serta penempatan-penempatan jabatan pada birokrasi terkesan terjadi praktek transaksional. Desain penelitian ini menggunakan jenis kualitatif melalui studi Pustaka dengan menggunakan konten analisis/analisis isi. Hasil penelitian bahwa Podhagāka Pamarinta Amarombumo Zamani adalah nilai karakter yang harus diimplementasikan pada setiap diri pemimpin. Proses pemilihan Kepemimpinan Sultan Buton mengedepankan kualitas karakter dan moralitas individu, pemimpin. Pencalonan Sultan prosesnya ditilik mulai dari calon sultan berusia dini yang berasal dari Tatanai landu, tapi-tapi dan kumbewaha yang dilakukan oleh Sio Limbona sebagai Lembaga legislative, sehingga pada penempatan jabatan pemerintahan maupun kepemimpinan kesultanan Buton tidak mengenal yang Namanya praktek money politik atau transaksional. Nilai ini seyogyanya dalam praktek sistem demokrasi kita dianut oleh sistem demokrasi dewasa ini khususnya pada pemilihan kepala daerah maupun legislatif. Nilai ini sangat menginpiratif terjadinya kehidupan demokrasi yang diinginkan Bersama.
Deflectometry for specular surfaces: an overview
Authors: Burke Jan , Pak Alexey , Höfer Sebastian , Ziebarth Mathias , Roschani Masoud , Beyerer Jürgen 
Published: July 2023

Deflectometry as a technique to assess reflective surfaces has now existed for some 40 years. Its different aspects and variations have been studied in multiple theses and research articles; reviews are available for certain subtopics. Still a field of active development with many unsolved problems, deflectometry now encompasses a large variety of application domains, hardware setup types, and processing workflows for different purposes, and spans a range from qualitative defect inspection of large vehicles to precision measurements of microscopic optics. Over these years, many exciting developments have accumulated in the underlying theory, in the systems design, and in the implementation specifics. This diversity of topics is difficult to grasp for experts and non-experts alike and may present an obstacle to a wider acceptance of deflectometry as a useful tool for research and industrial applications. This paper presents an attempt to summarize the status of deflectometry and to map relations between its notable branches. Its aim is to provide a communication basis for experienced practitioners and also to offer a convenient entry point for those interested in learning about the method. The list of references introduces some prominent trends and established research groups in order to facilitate further self-directed exploration.
Non-ammoniagenic proliferation and differentiation media for cultivated adipose tissue
Authors: Hubalek S. , Melke J. , Pawlica P. , Post M. J. , Moutsatsou P. 
Published: July 2023

Ammonia (Amm), and its aqueous solved state, ammonium, which is produced from glutamine (Gln) metabolism, is a known inhibitor of stem cell proliferation in vitro. In the context of cultivated beef, primary bovine fibro-adipogenic progenitor cells (FAPs) need to be grown and differentiated for several weeks in vitro for the production of cultivated fat. In this study, the ammonium sensitivity of these cells was investigated by introducing ammonium chloride, which was found to inhibit their proliferation when above 5 mM and their adipogenic differentiation when above 2 mM. Novel serum-free proliferation and differentiation media were hence developed with the aim to suppress Amm production during expansion and adipogenesis. Glutamine substitutes, such as a-ketoglutarate (aKG), glutamate (Glt) and pyruvate (Pyr) were investigated. It was found that aKG based proliferation medium (PM) was the most effective in promoting and maintaining FAPs growth over several passages while the specific Amm production rate was reduced more than 5-fold. In terms of differentiation capacity, the substitution of glucose (Gluc) and Gln with galactose (Gal) and Pyr was shown to be the most effective in promoting FAPs differentiation into mature adipocytes, resulting in over 2-fold increase of fat volume per cell, while suppressing Amm production. Our findings suggest that FAPs do not require Gln as an essential nutrient but, on the contrary, possess all the necessary metabolic pathways to proliferate and subsequently differentiate in a Gln-free medium, resulting in decreased Amm production rates and seemingly synthesising glutamine de novo. These findings are important for prolonging the lifespan of culture medium, allowing for reduced costs and process interventions.
A nonlinear relationship between systemic inflammation response index and short-term mortality in patients with acute myocardial infarction: a retrospective study from MIMIC-IV
Authors: Wang Yufei , Chen Hua 
Published: July 2023

BackgroundThis investigation aimed to evaluate the efficacy of the Systemic Inflammatory Response Index (SIRI) in prognosticating short-term all-cause mortality among patients diagnosed with acute myocardial infarction (AMI) in the intensive care unit (ICU).Methods and ResultsClinical data were obtained from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. A total of 4,291 patients were included in the cohort. Results from multivariate regression analyses showed that the quartile of the natural logarithm of SIRI (ln-SIRI) was independently associated with mortality. Compared to patients in the first quartile (Q1), patients in the second quartile (Q2) and fourth quartile (Q4) were significantly associated with an increased risk of 30-day (HR = 2.031, 95% CI: 1.604–2.571, p &lt; 0.001 and HR = 1.703, 95% CI: 1.32–2.195, p &lt; 0.001) and 90-day all-cause mortality (HR = 2.063, 95% CI: 1.68–2.532, p &lt; 0.001 and HR = 1.788, 95% CI: 1.435–2.227, p &lt; 0.001), which is consistent with the results of the Kaplan-Meier analysis and the results of multivariate regression analyses by classifying into 12 groups based on dodeciles of SIRI. Curve fitting showed a curvilinear relationship and further threshold saturation effects showed that, for 90-day mortality, each unit increased in ln-SIRI, when the ln-SIRI level is less than 2.9, the patient's mortality increases by 23.2% (OR: 1.232; 95% CI: 1.111–1.367; p &lt; 0.001); when the ln-SIRI is greater than 2.9 and less than 4.6, the patient's mortality decreases by 44.4% (OR: 0.554; 95% CI: 0.392–0.789; p = 0.001); when ln SIR &gt; 4.6, the patient's mortality increases by 24.7% (OR: 1.247; 95% CI: 1.108–1.404; p &lt; 0.001). Moreover, the length of stay in the hospital was lower in patients in the third quartile (Q3) (coefficient: −1.999; 95% CI: −2.834 – −1.165, p &lt; 0.001). The length of stay in the ICU was higher in patients in Q2 and Q4 (coefficient: 0.685;95% CI: 0.243–1.128; p = 0.0024 and coefficient: 0.989;95% CI: 0.528–1.451; p &lt; 0.001). Furthermore, SIRI may outperform NLR in predicting short-term mortality.ConclusionSIRI is an independent risk factor for 30- and 90-day mortality, and length of stay in ICU for critical AMI patients.