bluuebunny/crossref_metadata_2025_split huggingface dataset:
How geographic diversity and collaborative breadth prevent knowledge leakage during open innovation processes
Authors: Wang Chunhsien , Chin Tachia , Chiew Yuan Yin , Capalbo Cinzia 
Published: June 2023

Purpose
Drawing upon insights from knowledge-based theory and the learning perspective, this study aims to explore safeguarding strategies in open innovation. Geographic diversity and collaborative breadth can effectively protect proprietary innovations that limit knowledge leakage concerns.

Design/methodology/approach
Using a cross-industry sample from the Taiwanese Technological Innovation Survey III, which covered 1,519 firms, the authors investigate the conditions under which partnership portfolios affect radical innovation.

Findings
The findings suggest that the partnership portfolio has an inverted U-shaped influence on radical innovation and that this relationship is moderated by geographic diversity and collaborative breadth. This work identifies a balance in the tension between diverse partnership portfolios and knowledge leakage with regard to open innovation activities.

Practical implications
This study provides senior managers with an indication of the relationships between partnership portfolios and innovative knowledge protection, identifying the geographic diversity and collaborative breadth that serve as safeguards to prevent leakages of a firm’s innovative knowledge.

Originality/value
This study makes an original contribution to the empirical exploration of innovation knowledge protection and provides new insights into the field of open innovation. The authors, thus, balance the tension between partnership portfolios and knowledge leakage.
Employees out of sight, out of mind?
Authors: Hough Toby 
Published: June 2023

Purpose
Out of sight, out of mind is not a new phenomenon. It is always been a challenge for employers with a distributed workforce. However, what is new is the scale, so employers need to address this problem, and fast.

Design/methodology/approach
Company culture, checking in, keeping on top of communication and thinking about the team at all times are all vital to keeping employees top of mind.

Findings
By thinking about all of these areas of a workplace, employers will ensure their employees are happy, engaged and retained.

Originality/value
To help employers ensure the out of sight, out of mind phenomenon ends in 2023, here are the four top tips for employers to keep out of sight and in mind.
External causes of emergency department presentations: A missing piece to understanding unintentional childhood injury in Australia
Authors: Catchpoole Jesani , Niven Catherine , Möller Holger , Harrison James E , Ivers Rebecca , Craig Simon , Vallmuur Kirsten 
Published: June 2023

AbstractObjectiveTo identify external causes of unintentional childhood injury presenting to Australian EDs.MethodsSix major paediatric hospitals in four Australian states supplied de‐identified ED data for 2011–2017 on age, sex, attendance time/date, presenting problem, injury diagnosis, triage category and mode of separation. Three hospitals supplied data on external cause and intent of injury. A machine classifier tool was used to supplement the missing external cause coding in the remaining hospitals to enable the compilation of a standardised dataset for childhood injury causes analysis.ResultsA total of 486 762 ED presentations for unintentional injury in children aged 0–14 years were analysed. The leading specified cause of ED presentations was low fall (35.0%) followed by struck/collision with an object (13.8%) with little sex difference observed. Males aged 10–14 years had higher rates of motorcycle, pedal cycle and fire/flame‐related injury and lower rates of horse‐related injury and drug/medicinal substance poisoning compared with females. The leading specified external cause resulting in hospitalisation was low fall (32.2%) followed by struck/collision with an object (11.1%). The injuries with the highest proportion of children being hospitalised were drownings (64.4%), pedestrian (53.4%), motorcycle (52.7%) and horse‐related injuries (50.0%).ConclusionsThis is the first large‐scale study since the 1980s to explore external causes of unintentional childhood injury presenting to Australian paediatric EDs. It demonstrates a hybrid human–machine learning approach to create a standardised database to overcome data deficiencies. The results supplement existing knowledge of hospitalised paediatric injury to better understand the causes of childhood injury by age and sex, which require health service utilisation.
Relationship between immune‐related adverse events and treatment effectiveness in extensive disease small cell lung cancer
Authors: Yokoo Keiki , Kitamura Yauo , Suzuki Keito , Morikawa Kohei , Sawai Takeo , Honda Hiroyuki , Kudo Sayaka , Yamada Gen 
Published: June 2023

AbstractBackgroundThis study aimed to assess the relationship between immune response adverse events (irAEs) and treatment efficacy in patients with extensive disease small cell lung cancer (ED‐SCLC).MethodsWe retrospectively evaluated the clinical effects in 40 ED‐SCLC patients who had received immune‐checkpoint inhibitors (ICIs), platinum agents, and etoposide between September 2019 and September 2021. We identified and compared patients belonging to two groups: irAE and non‐irAE.ResultsFifteen patients experienced irAEs, and 25 did not. The median progression‐free survival in patients with irAE was longer than that in patients without irAE (12.6 months [95% CI: 6.3–19.3 months] vs. 7.2 months [95% CI: 5.8–7.9 months], p = 0.0108). However, the median overall survival (OS) was similar between irAE and non‐irAE groups (27.6 months [95% CI: 15.4–NA] vs. 24.9 months [95% CI: 13.7–NA], p = 0.268). Seven (46.7%) in the irAE group and 20 (80%) in the non‐irAE group received sequential therapy. The median OS was prolonged in patients who received first‐ and second‐line therapy than in those who received first‐line therapy alone (27.6 months [95% CI: 19.2–NA] vs. 6.6 months [95% CI: 0.3–NA], p = 0.053). Grade ≧ 3 irAEs occurred in five (12.5%) patients. Among them, grade 5 irAEs were observed in two patients, including exacerbation of polymyositis and pulmonary arterial embolism.ConclusionIn this study, the development of irAEs did not affect OS in patients with ED‐SCLC who received platinum‐based agents, etoposide, or ICI therapy. We determined that managing irAEs and administering first‐ and second‐line therapies could contribute to prolonged OS.
The deterrent effect of the SEC Whistleblower Program on financial reporting securities violations
Authors: Wiedman Christine , Zhu Chunmei 
Published: June 2023

AbstractThe stated goal of the SEC Whistleblower Program introduced as part of the Dodd‐Frank Act was to deter securities violations and thereby to strengthen investor protection. We document significant reductions in the likelihood of financial reporting fraud by US firms following the introduction of this program. The reductions are robust to controlling for other regulatory changes in the Dodd‐Frank Act and economic trends. Given that employees of firms with weaker internal compliance and reporting programs are more likely to report irregularities directly to the SEC rather than internally, we predict and find that these firms are more likely to change their reporting behavior. We also show that the observed reductions are attributable to an improvement in internal whistleblower programs and the hiring of more capable audit committee members after the program's inception. Collectively, these findings provide important large‐sample evidence of significant benefits of the SEC Whistleblower Program for deterring financial reporting fraud and of the efficacy of bounty‐type whistleblower programs.
Sex and age differences in AMPK phosphorylation, mitochondrial homeostasis, and inflammation in hearts from inflammatory cardiomyopathy patients
Authors: Barcena Maria Luisa , Tonini Greta , Haritonow Natalie , Breiter Pavelas , Milting Hendrik , Baczko Istvan , Müller‐Werdan Ursula , Ladilov Yury , Regitz‐Zagrosek Vera 
Published: June 2023

AbstractLinked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may lead to dilated cardiomyopathy. Although sex and age differences in the development of chronic myocarditis have been postulated, underlying cellular mechanisms remain poorly understood. In the current study, we aimed to investigate sex and age differences in mitochondrial homeostasis, inflammation, and cellular senescence. Cardiac tissue samples from younger and older patients with inflammatory dilated cardiomyopathy (DCMI) were used. The expression of Sirt1, phosphorylated AMPK, PGC‐1α, Sirt3, acetylated SOD2, catalase, and several mitochondrial genes was analyzed to assess mitochondrial homeostasis. The expression of NF‐κB, TLR4, and interleukins was used to examine the inflammatory state in the heart. Finally, several senescence markers and telomere length were investigated. Cardiac AMPK expression and phosphorylation were significantly elevated in male DCMI patients, whereas Sirt1 expression remained unchanged in all groups investigated. AMPK upregulation was accompanied by a preserved expression of all mitochondrial proteins/genes investigated in older male DCMI patients, whereas the expression of TOM40, TIM23, and the mitochondrial oxidative phosphorylation genes was significantly reduced in older female patients. Mitochondrial homeostasis in older male patients was further supported by the reduced acetylation of mitochondrial proteins as indicated by acetylated SOD2. The inflammatory markers NF‐κB and TLR4 were downregulated in older male DCMI patients, whereas the expression of IL‐18 was increased in older female patients. This was accompanied by progressed senescence in older DCMI hearts. In conclusion, older women experience more dramatic immunometabolic disorders on the cellular level than older men.
Melanocortin‐4 receptor and proopiomelanocortin: Candidate genes for obesity in domestic shorthair cats
Authors: Jerjen C. P. , Kumaran S. J. , Liesegang A. , Hall E. , Wichert B. , Haase B. 
Published: June 2023

AbstractObesity is an escalating global health problem affecting both humans and companion animals. In cats it is associated with increased mortality and multiple diseases, including diabetes mellitus. Two genes coding for proteins known to play a critical role in energy homeostasis across species are the proopiomelanocortin (POMC) gene and the melanocortin‐4 receptor (MC4R) gene. A missense variant in the coding sequence of the feline MC4R (MC4R:c.92C>T) has been reported to be associated with diabetes and overweight in domestic shorthair cats, and while variants in the POMC gene are known to cause obesity in humans and dogs, variants in POMC and their association with feline obesity and diabetes mellitus have not been investigated to date. The current study aimed to assess the association between the previously described MC4R variant and body condition score (BCS), as well as body fat content (%BF) in 89 non‐diabetic domestic shorthair cats. Furthermore, we investigated the feline POMC gene as a potential candidate gene for obesity. Our results indicate that the MC4R:c.92C>T polymorphism is not associated with BCS or %BF in non‐diabetic domestic shorthair cats. The mutation analysis of all POMC exons identified two missense variants, with a variant in exon 1 (c.28G>C; p.G10R) predicted to be damaging. The variant was subsequently assessed in all 89 cats, and cats heterozygous for the variant had a significantly increased body condition score (p = 0.03) compared with cats homozygous for the wild‐type allele. Results from our study provide additional evidence that the previously described variant in MC4R is not associated with obesity in domestic shorthair cats. More importantly, we have identified a novel variant in the POMC gene, which might play a role in increased body condition score and body fat content in domestic shorthair cats.
Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis
Authors: Zhang Qinxin , Wang Yan , Xu Yiyun , Zhou Ran , Huang Mingtao , Qiao Fengchang , Meng Lulu , Liu An , Zhou Jing , Li Li , Ji Xiuqing , Xu Zhengfeng , Hu Ping 
Published: June 2023

AbstractIntroductionChromosomal aberrations are the most important etiological factors for birth defects. Optical genome mapping is a novel cytogenetic tool for detecting a broad range of chromosomal aberrations in a single assay, but relevant clinical feasibility studies of optical genome mapping in prenatal diagnosis are limited.Material and methodsWe retrospectively performed optical genome mapping analysis of amniotic fluid samples from 34 fetuses with various clinical indications and chromosomal aberrations detected through standard‐of‐care technologies, including karyotyping, fluorescence in situ hybridization, and/or chromosomal microarray analysis.ResultsIn total, we analyzed 46 chromosomal aberrations from 34 amniotic fluid samples, including 5 aneuploidies, 10 large copy number variations, 27 microdeletions/microduplications, 2 translocations, 1 isochromosome, and 1 region of homozygosity. Overall, 45 chromosomal aberrations could be confirmed by our customized analysis strategy. Optical genome mapping reached 97.8% concordant clinical diagnosis with standard‐of‐care methods for all chromosomal aberrations in a blinded fashion. Compared with the widely used chromosomal microarray analysis, optical genome mapping additionally determined the relative orientation and position of repetitive segments for seven cases with duplications or triplications. The additional information provided by optical genome mapping will be conducive to characterizing complex chromosomal rearrangements and allowing us to propose mechanisms to explain rearrangements and predict the genetic recurrence risk.ConclusionsOur study highlights that optical genome mapping can provide comprehensive and accurate information on chromosomal aberrations in a single test, suggesting that optical genome mapping has the potential to become a promising cytogenetic tool for prenatal diagnosis.
Steering clear of Akrasia: An integrative review of self‐binding Ulysses Contracts in clinical practice
Authors: Brenna Connor T. A. , Chen Stacy S. , Cho Matthew , McCoy Liam G. , Das Sunit 
Published: June 2023

AbstractIn many jurisdictions, legal frameworks afford patients the opportunity to make prospective medical decisions or to create directives that contain a special provision forfeiting their own ability to object to those decisions at a future time point, should they lose decision‐making capacity. These agreements have been described with widely varying nomenclatures, including Ulysses Contracts, Odysseus Transfers, Psychiatric Advance Directives with Ulysses Clauses, and Powers of Attorney with Special Provisions. As a consequence of this terminological heterogeneity, it is challenging for healthcare providers to understand the terms and uses of these agreements and for ethicists to engage with the nuances of clinical decision‐making with such unique provisions surrounding patient autonomy. In theory, prospective self‐binding agreements may safeguard patient's “authentic” wishes from future “inauthentic” changes of mind. In practice, it is unclear what may be comprised within these agreements or how—and to what effect—they are used. The primary focus of this integrative review is to curate the existing literature describing Ulysses Contracts (and analogous decisions) used in the clinical arena, in order to empirically synthesize their shared essence and provide insights into the traditional components of these agreements when used in practice, the requirements of their consent processes, and the outcomes of their utilization.
Expectations and the housing market: A model of house price dynamics
Authors: Hong Jengei , Ryu Doojin 
Published: June 2023

AbstractWe examine the characteristics of housing markets under adaptive and heterogeneous expectations. Model agents have finite horizons, and their borrowings are constrained by the collateral value of housing stock. Our model shows that expectation‐driven housing price dynamics constantly change the direction of movement. The steady‐state process of housing prices follows an endogenous oscillation process, and the magnitude of the cycles can be amplified by external shocks. Our quantitative results imply that (i) short‐term positive and long‐term negative serial correlations in housing price changes are inherent, (ii) house prices and expected house price movements are positively correlated, and (iii) fluctuations in housing prices are not fully explained by fundamentals.
Doppler Volume Rendering: A Dynamic, Piecewise Linear Spectral Representation for Visualizing Astrophysics Simulations
Authors: Alghamdi Reem , Müller Thomas , Jaspe‐Villanueva Alberto , Hadwiger Markus , Sadlo Filip 
Published: June 2023

AbstractWe present a novel approach for rendering volumetric data including the Doppler effect of light. Similar to the acoustic Doppler effect, which is caused by relative motion between a sound emitter and an observer, light waves also experience compression or expansion when emitter and observer exhibit relative motion. We account for this by employing spectral volume rendering in an emission–absorption model, with the volumetric matter moving according to an accompanying vector field, and emitting and attenuating light at wavelengths subject to the Doppler effect. By introducing a novel piecewise linearear representation of the involved light spectra, we achieve accurate volume rendering at interactive frame rates. We compare our technique to rendering with traditional point‐based spectral representation, and demonstrate its utility using a simulation of galaxy formation.
Do Disease Stories Need a Hero? Effects of Human Protagonists on a Narrative Visualization about Cerebral Small Vessel Disease
Authors: Mittenentzwei S. , Weiß V. , Schreiber S. , Garrison L. A. , Bruckner S. , Pfister M. , Preim B. , Meuschke M. 
Published: June 2023

AbstractAuthors use various media formats to convey disease information to a broad audience, from articles and videos to interviews or documentaries. These media often include human characters, such as patients or treating physicians, who are involved with the disease. While artistic media, such as hand‐crafted illustrations and animations are used for health communication in many cases, our goal is to focus on data‐driven visualizations. Over the last decade, narrative visualization has experienced increasing prominence, employing storytelling techniques to present data in an understandable way. Similar to classic storytelling formats, narrative medical visualizations may also take a human character‐centered design approach. However, the impact of this form of data communication on the user is largely unexplored. This study investigates the protagonist's influence on user experience in terms of engagement, identification, self‐referencing, emotional response, perceived credibility, and time spent in the story. Our experimental setup utilizes a character‐driven story structure for disease stories derived from Joseph Campbell's Hero's Journey. Using this structure, we generated three conditions for a cerebral small vessel disease story that vary by their protagonist: (1) a patient, (2) a physician, and (3) a base condition with no human protagonist. These story variants formed the basis for our hypotheses on the effect of a human protagonist in disease stories, which we evaluated in an online study with 30 participants. Our findings indicate that a human protagonist exerts various influences on the story perception and that these also vary depending on the type of protagonist.
VisCoMET: Visually Analyzing Team Collaboration in Medical Emergency Trainings
Authors: Liebers C. , Agarwal S. , Krug M. , Pitsch K. , Beck F. 
Published: June 2023

AbstractHandling emergencies requires efficient and effective collaboration of medical professionals. To analyze their performance, in an application study, we have developed VisCoMET, a visual analytics approach displaying interactions of healthcare personnel in a triage training of a mass casualty incident. The application scenario stems from social interaction research, where the collaboration of teams is studied from different perspectives. We integrate recorded annotations from multiple sources, such as recorded videos of the sessions, transcribed communication, and eye‐tracking information. For each session, an information‐rich timeline visualizes events across these different channels, specifically highlighting interactions between the team members. We provide algorithmic support to identify frequent event patterns and to search for user‐defined event sequences. Comparing different teams, an overview visualization aggregates each training session in a visual glyph as a node, connected to similar sessions through edges. An application example shows the usage of the approach in the comparative analysis of triage training sessions, where multiple teams encountered the same scene, and highlights discovered insights. The approach was evaluated through feedback from visualization and social interaction experts. The results show that the approach supports reflecting on teams' performance by exploratory analysis of collaboration behavior while particularly enabling the comparison of triage training sessions.
How certain are we about the role of uncertainty in the economy?
Authors: Herwartz Helmut , Lange Alexander 
Published: June 2023

AbstractWhile causes and consequences of uncertainty in the US economy have attracted viable interest, the literature still lacks a consensus on several aspects. To name two matters of debate, it remains unclear whether uncertainty shocks are a source or the result of recessions and whether uncertainty shocks have adverse (or even stimulating) effects on the economy. We find that ambiguous results in these regards can be traced back to the selection of an appropriate identification strategy in structural vector autoregressive models. We find that both macroeconomic and financial uncertainty are exogenous to business cycle fluctuations and cause economic slowdowns.
Potential efficacy and safety of eslicarbazepine acetate oral loading in patients with epilepsy
Authors: Kwack Dong Won , Kim Dong Wook 
Published: June 2023

AbstractEslicarbazepine acetate (ESL) is a new antiseizure medication (ASM) approved as an adjunctive therapy or monotherapy for focal onset seizures. We performed this study to explore the potential efficacy and safety of ESL oral loading in selected patients with epilepsy. Thirty adult patients with status epilepticus or acute repetitive seizures were enrolled, and ESL was administered at a single loading dosage of 30 mg/kg. Plasma levels of an active metabolite of ESL, monohydroxy derivative (MHD), were measured at 2, 4, 6, 12, and 24 h after ESL oral loading. Two thirds of the patients reached a therapeutic level of MHD 2 h after ESL loading, and most of the patients achieved a therapeutic range within 12 h after loading. Plasma MHD levels did not rise above the supratherapeutic level in any patient throughout the study. The reported adverse effects included one patient with gaze‐evoked nystagmus and another patient with a rash. No serious adverse events leading to drug discontinuation occurred. There was no discernible difference in sodium levels before and after ESL oral loading. Our study findings suggest that ESL oral loading could be a useful therapeutic option for patients with epilepsy who need rapid elevations in the therapeutic levels of ASMs.