bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction hepatic arterial infusion chemotherapy with concurrent radiotherapy followed by surgery for hepatocellular carcinoma with massive portal vein tumor thrombosis
Authors: Kimura Yuta , Tokumitsu Yukio , Shindo Yoshitaro , Matsui Hiroto , Matsukuma Satoshi , Saeki Issei , Takami Taro , Yamasaki Takahiro , Ioka Tatsuya , Nagano Hiroaki 
Published: May 2023

Abstract
Background
The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is very poor, and the optimal treatment remains controversial. The aim of this study was to examine the safety and feasibility of our multimodal treatment.
Methods
This was a single-institution, retrospective case series. From 2013 to 2018, induction hepatic arterial infusion chemotherapy (HAIC) with concurrent radiotherapy (RT) was given to 20 consecutive patients with HCC harboring PVTT in the main portal trunk or first branch, even with intrahepatic and extrahepatic metastasis. When the cancers including thrombus and metastatic disease were well-controlled, surgical resection was considered. When macroscopic complete resection was achieved, two courses of HAIC were added as adjuvant therapy, whereas patients who had remnant disease after surgery were provided treatment according to the type of lesion.
Results
No treatment-related deaths were noted. The objective response rate and disease control rate were 35.0% and 65.0%, respectively. After induction treatment, 10 of 20 patients underwent surgery. Postoperative complications (Clavien-Dindo Grade III or more) were observed in three cases, and median postoperative hospital stay was 15.5 days. Median survival time of all 20 patients was 14.5 months, and that in patients who underwent surgery was significantly longer than that in patients with unresectable HCC (19.5 months vs 9.0 months, p = 0.0018).
Conclusions
Induction treatment followed by surgery was safe and feasible for HCC with massive PVTT. Surgical resection might be oncologically appropriate for selected patients after induction treatment even with advanced stage HCC.
Deficiency of acetyltransferase nat10 in zebrafish causes developmental defects in the visual function and behavior
Authors: Yang Hou-Zhi , Zhuo Donghai , Huang Zongyu , Luo Gan , Liang Shuang , Fan Yonggang , Zhao Ying , Lv Xinxin , Qiu Caizhen , Zhang Lingzhu , Liu Yang , Sun Tianwei , Chen Xu , Li Shan-Shan , Jin Xin 
Published: May 2023

Abstract
N4-acetylcytidine (ac4C) is an epitranscriptomic modification of mRNA that is catalyzed by N-acetyltransferase 10 (NAT10), a critical factor known to influence mRNA stability. However, its role in development has not been investigated. In this study, we used CRISPR/Cas9 and RNAi technology to knock out and knock down nat10, the zebrafish ortholog of human NAT10, and evaluated their effects on development, behavior, and transcriptome. Our findings indicate that nat10 deficiency in zebrafish embryos results in increased embryo mortality and developmental abnormalities. Additionally, behavioral and histological evaluations revealed that nat10 knockdown led to increased anxiety-like behavior and severe vision impairment. Transcriptome profiling and RT-PCR results showed that nat10 knockdown significantly downregulated the expression of retinal transcripts that are enriched in response to light stimuli, photoreceptors, and visual perception. Furthermore, dot-blot and RIP-PCR analyses confirmed a significant reduction in ac4C levels in total RNA and opsin mRNA in nat10 knockdown zebrafish. Our results highlight the essential role of ac4C in embryonic development, especially in visual development. This zebrafish model could be helpful for studying ac4C modification in neurodevelopmental disorders.
Quantum and Relativistic corrections to Maxwell-Boltzmann ideal gas model from a Quantum Phase Space approach
Authors: Ravelonjato Rivo Herivola Manjakamanana , Ranaivoson Ravo Tokiniaina , Andriambololona Raoelina , Raboanary Roland , Rakotoson Hanitriarivo , Rabesiranana Naivo 
Published: May 2023

Abstract
The quantum corrections related to the ideal gas model that are often considered are those which are related to the particles nature: bosons or fermions. These corrections leadrespectively to the Bose-Einstein and Fermi-Dirac statistics. However, in this work, otherkinds of corrections which are related to the quantum nature of phase space are considered. These corrections are introduced as improvement in the expression of the partition function of an ideal gas. Then corrected thermodynamics properties of the gas are deduced. Both the non-relativistic quantum and relativistic quantum cases are considered. It is shown that the corrections in the non-relativistic quantum case may be particularly useful to describe the deviation from classical behavior of a Maxwell-Boltzmann gas at low temperature and in confined space. These corrections can be considered as including the description of quantum size and shape effects. For the relativistic quantum case, the corrections could be relevant for confined space and when the thermal energy of each particle is comparable to their rest energy. The corrections appear mainly as modifications in the thermodynamic equation of state and in the expressions of the partition function and thermodynamic functions like entropy, internal energy, and free energy. Classical expressions are obtained as asymptotic limits.
In Vitro Cytotoxic Activity of Quercetin and Silymarin and Their Synergistic Effect on Hep G2 Cell Lines
Authors: Raut Dinesh , Deore Manswi , Shirode Devndra 
Published: May 2023

Abstract
Purpose
One of the biggest causes of mortality among people is cancer. Plants may contain potential bioactive substances that might be used to provide "new leads" in the fight against cancer and other disorders. The main objective of this present study was to evaluate the cytotoxic activities of Quercetin and Silymarin and their Synergistic effect on Hep G2.
Method
The cytotoxic activity of this individual drug and in combination was confirmed by the consideration of IC50 by MTT assay.
Results
The results show that IC50 of Quercetin 50 µg, Silymarin 40 µg, and combination 30 µg respectively. The combination of these drugs shows a significant increase in cytotoxic effect and anti-proliferative effect compared with individual drugs. Thus, the results indicate that this combination has anti -hyper carcinogenic effect.
Danger, Students Beware, School Ahead! Gun Violence Exposure Near Schools in Compton, California
Authors: Barboza Gia , Meshelemiah Jacquelyn 
Published: May 2023

Abstract

Gun-related violence exposure is a significant public health problem for urban youth. Few studies have implemented methods to estimate the spatial influence of activity spaces on gun violence exposure constrained by the physical configuration of walkable street networks. The present research uses computational network and local indicators of spatial autocorrelation methods to explore gun violence exposure along the walkable streets near schools in Compton, California. Findings demonstrated strong evidence that gun violence is clustered at all distances along the pedestrian network and in proximity to Compton Unified School District K-12 schools reaching a maximum between 1.2-1.8 miles after which the attractiveness of schools to gun violence was inhibiting. Almost all schools had at least one shooting within a 5-minute walk (i.e., about 400 m); 37.8% of schools had an average shooting distance less than 400 meters; about 250 incidents occurred within 5-minutes of schools, and about 30 schools had a shooting within a 5-minute walking distance. Determining the spatial extent of violence exposure in proximity to key activity spaces for youth, such as schools, has substantial implications for youth living in violence-prone areas. The public health and legal implications of this study are discussed in context.
The technical assessment of the level of innovative traction transmission of railway vehicle
Authors: Abdullaev Ayaz , Huseynov Ilham , Elyazov Israil , Abdullaev Ramin 
Published: May 2023

The article deals with the development of an innovative model of traction transmissions of railway vehicles with a higher technical level, which allows to eliminate the existing shortcomings of the mechanical system, simplify the repair processes and reduce the cost, and evaluate its technical level. By reducing the overall dimensions and weight of the mechanical system, increasing reliability due to equal distribution of the load and shortening the power arm, as well as reducing the number of structural elements, increasing the useful work coefficient due to the reduction of the mass of double sliding pads and rotating parts, saving electricity and thereby improving the technical level of rail transport. Traction transmissions consisting of an innovative reducer are offered that ensure the increase.
The technical level of the proposed dart transmission is determined based on three compatibility parameters with a creative approach. Compatibility parameters are determined according to the minimum value of the geometric dimensions characterizing the mass of the mechanical system, the maximum value of the useful work coefficient characterizing economic efficiency, as well as the maximum values of the degree of reliability characterizing safety. The technical level of the proposed project transmitter is determined and compared with existing buildings, its technical and economic advantages are highlighted. As a result of the application of the proposed innovative reducers in the traction drives of railway vehicles, the basis is created for reducing the cost and maintenance costs of traction vehicles, increasing the level of traffic safety, as well as improving the traction and braking characteristics
Insights Into the Synthetic Strategies, Biological Activity, and Structure-
Activity Relationship of Pyridine and Analogs: A Review
Authors: Matthew Aprajita , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Bhadauria Harshita 
Published: May 2023

Abstract:
Based on various research reports, pyridine possesses a wide range of pharmacological activities
along with many other industrial applications. Because of its diverse applications, pyridine
moiety is the center of attraction for researchers, and many patents have been granted focusing on it.
Several synthetic protocols, such as cyclo-condensation, cyclization, cycloaddition, electrolysis, etc.,
were used by researchers to synthesize pyridine and analogs. Each synthetic protocol has merits and
demerits and requires several types of reagents, catalysts, and reaction conditions. So, there is always
a need for careful analysis of reported synthetic protocols whenever researchers like to initiate research
on synthesizing pyridine and its analogs. The therapeutic activity of successfully marketed
drugs might be possible because of the presence of pyridine in their structure. Any small alteration in
the structure of the medicinal compounds may produce a major change in their pharmacological action.
So, the correlation between the structure of its analogs with biological activity is also important.
The proposed article also includes recently reported pharmacological activities and the structureactivity
relationship of pyridine and its analogs. This article aims to help the researchers by highlighting
recently reported methods for synthesizing pharmacologically useful pyridine analogs and their
merits.
Chemistry of Thieno [2,3-h]-/[3,2-h] Quinoline and Thieno [2,3-f]-/[3,2-f]
Quinoline Derivatives Part (x), Reactivities, and Biological Activities
Authors: Gouda Moustafa A. , Al-Hadhrami Nahlah A. , Abu-Hashem Amin A. , Abdelgawad Ahmed A.M. , Salem Mohamed A. 
Published: May 2023

Abstract:
Several thieno [2,3-h] /[3,2-h] quinolines and thieno [2,3-f] /[3,2-f] quinolines (TQs) are
discussed in this review from a few perspectives, including various preparation and processing methods
employing cutting-edge machinery. The preparation of (TQs), from 4-(5)aminobenzothiophene,
2(3)chloromethylthiophene, 2(3)thienylboric acid, and other chemical reagents is illustrated via a
number of chemical procedures in this review. The formation of (TQs) was clarified using the Michael
addition, Photocyclization, Skraup reaction, Ullmann-Fetvadjian process, Suzuki-Miyaura and
Sonogashira reaction, aza-Diels-Alder reaction, and Friedel-Crafts reaction.
Hospital Food Services Satisfaction Survey among Healthcare
Professionals in a Tunisian University Hospital
Authors: Chelly Souhir , Werchfeni Bouthaina Trabelsi , Maatouk Amani , Dhaouadi Nawel , Ezzi Olfa , Ammar Asma , Njah Mansour , Mahjoub Mohamed 
Published: May 2023

Background:
Periodic monitoring of food quality can help determine the staff’s satisfaction
at any institution, such as the hospital. However, the lack of published studies on the evaluation
of staff’s satisfaction with hospital food prompted us to conduct the first survey on this topic in
Tunisia. The aim was to determine the prevalence of food satisfaction among health professionals
and identify factors affecting the satisfaction level.

Methods:
It was an analytic cross-sectional study conducted among all staff members of Farhat
Hached University Hospital in Sousse in November 2020. Data collection took place over a period
of 10 days with one service being surveyed per day. Free and informed consent was obtained from
all participants. Categorical variables were described in percentages and compared using the Chisquare
test. Univariate analyses were performed to examine associations between the level of satisfaction
and various factors. Binary logistic regression was used to eliminate confounding factors.

Results:
A total of 240 professionals participated in the survey. The majority were female (72.5%)
with an M/F sex ratio of 0.38, under 40 years old (94.6%), medical doctors (78.8%), and having less
than 5 years of professional experience (73.3%). The overall satisfaction rate was 33.3%. The majority
of healthcare professionals were not satisfied with the quality of food (75.8%) and with the
personal hygiene of staff who presented the food (78.4%). Factors associated with hospital food
satisfaction were the taste and variety of food, cleanliness, quality of dishes, and consuming the
entire meal.

Conclusion:
It is the first study to report the meal experience as perceived by hospital staff in Tunisia.
The overall satisfaction rate has been found to be 33.3%, which remains low. Efforts should be
made to improve the presentation of all meals. Periodic monitoring of food quality can help determine
if recommendations and staff expectations are being met.
Salt-and-pepper Noise Reduction for Medical Images based on Image Fusion
Authors: Wu Shixiao , Guo Chengcheng , Wang Xinghuan 
Published: May 2023

Background:
During the collection process, the prostate capsula is prone to introduce salt and pepper noise due to gastrointestinal peristalsis, which will affect
the precision of subsequent object detection.

Objective:
A cascade optimization scheme for image denoising based on image fusion was proposed to improve the peak signal-to-noise ratio (PSNR) and
contour protection performance of heterogeneous medical images after image denoising.

Methods:
Anisotropic diffusion fusion (ADF) was used to decompose the images denoised by adaptive median filter, non-local adaptive median filter and
artificial neural network to generate the base layer and detail layer, which were fused by weighted average and Karhunen-Loeve Transform
respectively. Finally, the image was reconstructed by linear superposition.

Results:
Compared with the traditional denoising method, the image denoised by this method has a higher PSNR while maintaining the image edge contour.

Conclusion:
Using the denoised dataset for object detection, the detection precision of the obtained model is higher.
Network Pharmacology Combined with GEO Analysis of the Mechanism
of Qing-Jin-Hua-Tan Decoction in the Treatment of Non-small Cell Lung
Cancer
Authors: Wei Yi , Liu Chao 
Published: May 2023

Background:
Non-small-cell lung cancer (NSCLC) is one of the most prevalent malignancies
and poses a significant threat to human health. Qing-Jin-Hua-Tan (QJHT) decoction is a
classical herbal remedy that has demonstrated therapeutic effects in various diseases, including
NSCLC, and can improve the quality of life of patients with respiratory conditions. However, the
mechanism underlying the effect of the QJHT decoction on NSCLC remains unclear and requires
further investigation.

Methods:
We collected NSCLC-related gene datasets from the GEO database and performed differential
gene analysis, followed by using WGCNA to identify the core set of genes associated
with NSCLC development. The TCMSP and HERB databases were searched to identify the active
ingredients and drug targets, and the core gene target datasets related to NSCLC were merged to
identify the intersecting targets of drugs and diseases for GO and KEGG pathway enrichment
analysis. We then constructed a protein-protein interaction (PPI) network map of drug diseases
using the MCODE algorithm and identified key genes using topology analysis. The disease-gene
matrix underwent immunoinfiltration analysis, and we analyzed the association between intersecting
targets and immunoinfiltration.

Results:
We obtained the GSE33532 dataset that met the screening criteria, and a total of 2211
differential genes were identified using differential gene analysis. We performed GSEA analysis
and WGCNA analysis for a crossover with differential genes, resulting in 891 key targets for
NSCLC. The drug database was screened to obtain 217 active ingredients and 339 drug targets of
QJHT. By constructing a PPI network, the active ingredients of QJHT decoction were intersected
with the targets of NSCLC, resulting in 31 intersected genes. Enrichment analysis of the intersection
targets showed that 1112 biological processes, 18 molecular functions, and 77 cellular compositions
were enriched in GO functions, and 36 signaling pathways were enriched in KEGG
pathways. Based on immune-infiltrating cell analysis, we found that the intersection targets were
significantly associated with multiple infiltrating immune cells.

Conclusion:
Our analysis using network pharmacology and mining of the GEO database revealed
that QJHT decoction can potentially treat NSCLC through multi-target and multi-signaling pathways,
while also regulating multiple immune cells.
A Comprehensive Review on Exosome: Recent Progress and Outlook
Authors: Agarwal Paras , Anees Adiba , Harsiddharay Raval Kavit , Kumar Pranesh , Tripathi Pushpendra Kumar 
Published: May 2023

Abstract:
Exosomes are intrinsic membrane-based vesicles that play a key role in both normal and
pathological processes. Since their discovery, exosomes have been investigated as viable drug delivery
systems and clinical indicators because of their magnitude and effectiveness in delivering biological
components to targeted cells. Exosome characteristics are biocompatible, prefer tumor recruitment, have
tunable targeting efficiency, and are stable, making them outstanding and eye-catching medication delivery
systems for cancer and other disorders. There is great interest in using cell-released tiny vesicles
that activate the immune system in the age of the fast development of cancer immunotherapy. Exosomes,
which are cell-derived nanovesicles, have a lot of potential for application in cancer immunotherapy
due to their immunogenicity and molecular transfer function. More significantly, exosomes can
transfer their cargo to specified cells and so affect the phenotypic and immune-regulation capabilities of
those cells. In this article, we summarize exosomes' biogenesis, isolation techniques, drug delivery, applications,
and recent clinical updates. The use of exosomes as drug-delivery systems for small compounds,
macromolecules, and nucleotides has recently advanced. We have tried to give holistic and exhaustive
pieces of information showcasing current progress and clinical updates of exosomes.
Phytochemical and Pharmacological Profile of Desmodium gangeticum
(L.) DC.: A Comprehensive Review
Authors: Bora Manajit , Mandal Suman , Singh Puneet Kumar , Das Himangi , Bora Girindra Kumar , Bora Devanjal , Baruah Dinesh , Gautam Manish Kumar 
Published: May 2023

Abstract:
Desmodium gangeticum (L.) DC., commonly known as Shalparni in Ayurveda, has been
used for treating various diseases. The plant is one among ten ingredients of classical Ayurvedic
formulations Dasamula. Decoctions of root and leaf, root powder and leaf juice of D. gangeticum
are used as tonics, febrifuge, digestive, antiemetic, astringent, anti-asthmatic, anti-diarrhoeal and anti-inflammatory agents in traditional medicinal practices of India and its neighbouring countries.
Phytochemical investigations of this plant revealed the presence of many bioactive phytoconstituents. The present review was prepared with the objective of documenting the phytochemical and
pharmacological profiles of D. gangeticum. The data presented here were collected from various
sources like books, journals, various online databases, and monographs and internet search engines
Google Scholar, PubMed, Science Direct, etc. Studies reported from phytochemical screening revealed that D. Gangeticum leaves and roots are rich in flavonoids, alkaloids, terpenoids, tannins,
phenols, carbohydrates, steroids, phenylpropanoids, pterocarpans, coumarins, and volatile oil.
Among the isolated compounds, major bio-active constituents are alkaloids, flavonoids and pterocarpans. All these phytochemicals are widely distributed in various parts of D. gangeticum. The
other active constituents like desmodin, hordenine and gangetin are largely responsible for its broad
spectrum of therapeutic potentiality. Desmodin belongs to the class of pterocarpans and is reported
to have antifungal and antibacterial activities. Gangetin, which also belongs to the pterocarpans, is
reported to have anti-inflammatory and analgesic effects. FTIR spectroscopy showed that D. gangeticum extracts are mainly rich in phenolic derivatives. Scientific experiments carried out in vitro
as well as preclinical animal experimentations, showed that the plant and its bioactive chemicals
exhibit various therapeutic activities. It is reported that D. gangeticum extracts showed potent antioxidant, antibacterial, hypoglycaemic, analgesic, hepatoprotective, anti-inflammatory and antiarthritic activities. Studies reported that D. gangeticum or its formulations are safe when used in appropriate therapeutic dosage.
Assessing and Mitigating Bias in Artificial Intelligence: A Review
Authors: Sinha Akruti , Sapra Devika , Sinwar Deepak , Singh Vijander , Raghuwanshi Ghanshyam 
Published: May 2023

Abstract:
There has been an exponential increase in discussions about bias in Artificial Intelligence
(AI) systems. Bias in AI has typically been defined as a divergence from standard statistical patterns
in the output of an AI model, which could be due to a biased dataset or biased assumptions.
While the bias in artificially taught models is attributed able to bias in the dataset provided by humans,
there is still room for advancement in terms of bias mitigation in AI models. The failure to
detect bias in datasets or models stems from the "black box" problem or a lack of understanding of
algorithmic outcomes. This paper provides a comprehensive review of the analysis of the approaches
provided by researchers and scholars to mitigate AI bias and investigate the several methods of
employing a responsible AI model for decision-making processes. We clarify what bias means to
different people, as well as provide the actual definition of bias in AI systems. In addition, the paper
discussed the causes of bias in AI systems thereby permitting researchers to focus their efforts on
minimising the causes and mitigating bias. Finally, we recommend the best direction for future
research to ensure the discovery of the most accurate method for reducing bias in algorithms. We
hope that this study will help researchers to think from different perspectives while developing
unbiased systems.