bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of transfer learning models for grading of diabetic retinopathy
Authors: M Sowmiya , Rekha B Banu , E Malar 
Published: July 2023

Diabetic retinopathy is a potentially mortal diabetic complication. The severity level of DR must be identified earlier to reduce the medical complications. Effective automated ways for identifying DR and classifying its severity stage are necessary to reduce the burden on ophthalmologists. Transfer learning methods are utilized to automatically grade the severity of diabetic retinopathy in this study. The stages of DR are diagnosed using pretrained VGG16, Inception v3, and ResNet50 models on pre-processed retinal images of DDR dataset. Out of three implemented models, Inception v3 achieved higher validation accuracy of 76.47% and testing accuracy of 67% compared to VGG16 and ResNet50 models. This research contributes to the analysis of deep learning architectures for the creation of automated diabetic retinopathy stage diagnosis and grading
Analysis of multiple sleeps and N-policy on a M/G/1/K user request queue in 5g networks base station
Authors: Merit C K Deena , M Haridass 
Published: July 2023

The primary purpose of green communication is to reduce energy use. The base station (BS) is a radio receiver/transmitter that acts as the wireless network’s hub. It serves as a link between a wired and wireless network. To receive and transmit messages, BS uses a lot of energy. The use of effective sleep and wake-up/setup activities with an acceptable delay helps reduce base station power consumption. In this paper, the BS’s service process is modelled as a finite buffer queue with close down, sleep, and setup. After a certain number of user requests (URs) have accumulated in the system, to awaken the BS from multiple sleeps (MS) the -Policy is implemented. To produce probability generating functions, the supplementary variable approach is applied. The UR’s mean delay and the BS’s mean power consumption are calculated using simulation. According to computational studies, multiple sleeps with -policy consume less power than multiple sleeps without -policy.
Mental Health Promotion for Productivity of Employee at Workplace in Indonesia
Authors: Irfani Adib Mumtaz , Bantarti Wisni 
Published: July 2023

Existing job opportunities are followed by different responsibilities. The higher the economic growth, the more complex the competition will be, thus making the responsibility for the work even heavier. This condition has a high impact on the potential for the Indonesian people to experience mental health problems which will ultimately have an effect to the productivity of each individual and have a collective impact on the performance of the company. The purpose of this research is to understand the usage of mental health promotion to leverage productivity Employee in Workforce. This study uses a literature review research method or literature review in analyzing and studying cases. The result of this study showed that three strategies for implementing mental health promotion in the work environment, namely Mental health promotion through working motivation and work environment, Mental health promotion through ethical leadership and psychological empowerment, and Mental health promotion through self-efficacy and employee engagement.
Ultrasonication‐Assisted Seed Screening Enables Oriented and Efficient Low‐Dimensional Crystal‐Structural Thin‐Film Photovoltaics
Authors: Yan Bin , Feng Mingjie , Wang Cong , Li Zongbao , Lu Wenbo , Liu Shunchang , Hu Jin‐Song , Xue Ding‐Jiang 
Published: July 2023

AbstractUltrasonication‐assisted liquid exfoliation of layered materials is widely used to produce a large number of 2D nanosheets due to its simplicity, universality, and mass production. Here, the utility of ultrasonication is extended from liquid exfoliation to seed screening in the case of layered GeSe and GeS. It is found that the ultrasonic stripping force can also be used to selectively remove the lying seeds interacting with substrate through weak van der Waals (vdW) forces while retaining the standing seeds connected with substrate via tightly covalent bonds. The standing seeds then induce the growth of 2D crystal‐structural films with standing orientation. This thereby enables efficient carrier transport within covalently bonded layers, instead of poor transport between layers held together by vdW forces. The resulting standing‐oriented GeSe films exhibit a 21‐times increase in carrier mobility compared to lying‐oriented films. As a result, this study demonstrates the highest power conversion efficiencies of 6.1% and 10.5% under AM1.5G 1‐ and 0.01‐sun illumination reported for GeSe solar cells, respectively.
Tannic Acid‐Based Nanomaterials for Tolerogenic Immunotherapy of Rheumatoid Arthritis
Authors: Wu Yina , Park Jinwon , Jin Dongun , Lee Jaiwoo , Le Quoc‐Viet , Oh Yu‐Kyoung 
Published: July 2023

AbstractHere, a tannic acid‐based nanomaterial is developed for treating rheumatoid arthritis by inducing antigen‐specific immune tolerance. The tolerogenic nanovaccine is designed for targeted delivery of dexamethasone and citrullinated peptide in a lipid‐coated nanoparticle consisting of tannic acid as core nanomaterial (CitDTN). The surface of CitDTN is modified with abatacept to yield AbaCitDTN. Abatacept modification enables the tolerogenic nanovaccine to target dendritic cells by interacting with the co‐stimulatory molecules, CD80 and CD86. This modification increases the lymph node accumulation of the tolerogenic nanovaccine upon subcutaneous administration. In addition, AbaCitDTN reprograms the properties of dendritic cells toward tolerogenic phenotypes and interrupts co‐stimulatory signals between dendritic cells and T cells, leading to suppressed T cell proliferation and interlukin‐2 secretion. Collagen‐induced arthritis DBA/1 model mice are subcutaneously administered with AbaCitDTN weekly for a total of four injections. This reduces inflammation in the synovial space and decreases autoimmunity against type II collagen and citrullinated peptide. In vivo administration of AbaCitDTN improves clinical symptoms and protects joints from destruction in this animal model. These findings suggest that tannic acid‐based nanomaterials could have potential to induce antigen‐specific immune tolerance for treating rheumatoid arthritis.
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery
Authors: Biancacci Ilaria , De Santis Daniele , Rama Elena , Benderski Karina , Momoh Jeffrey , Pohlberger Robert , Moeckel Diana , Kaps Leonard , Rijcken Cristianne J. F. , Prakash Jai , Thewissen Marielle , Kiessling Fabian , Shi Yang , Peña Quim , Sofias Alexandros Marios , Consolino Lorena , Lammers Twan 
Published: July 2023

AbstractThe dense stromal matrix in fibrotic tumors hinders tumor‐targeted drug delivery. Tamoxifen (TMX), an estrogen receptor modulator that is clinically used for the treatment of breast cancer, is shown to reprogram the tumor microenvironment (TME) and to alleviate desmoplasia. It is investigated if TMX, administered in free and nano‐formulated form, can be repurposed as a TME remodeling agent to improve tumor accumulation of nano‐formulations in pancreatic ductal adenocarcinoma and triple‐negative breast cancer mouse models, evaluated using clinical‐stage Cy7‐labeled core‐crosslinked polymeric micelles (CCPM). Under control conditions, higher levels of Cy7‐CCPM are found in PANC‐1 tumors (16.7% ID g−1 at 48 h post i.v. injection) than in 4T1 tumors (11.0% ID g−1). In both models, free and nano‐formulated TMX failed to improve CCPM delivery. These findings are congruent with the results from histopathological immunofluorescence analysis of tumor tissue, which indicate that TMX treatment does not significantly change vascularization, perfusion, macrophage infiltration, collagen density, and collagen fiber thickness. Altogether, these results demonstrate that in PANC‐1 and 4T1 mouse models, TMX treatment does not contribute to beneficial TME priming and enhanced tumor‐targeted drug delivery.
Synthesis, Reaction Mechanism, DNA Cleavage and Antitumor Properties of Naphthoquinone‐Based Enediynes
Authors: Zheng Hongyu , Zeng Yun , Huang Xiaohua , Zhang Houjun , Pu Fangxu , Cheng Haonan , Li Zhuoyu , Ding Yun , Hu Aiguo 
Published: July 2023

AbstractUnder physiological conditions, natural enediynes antibiotics generate free radicals through a cycloaromatization reaction. The resulting highly reactive radicals can abstract hydrogen atoms on the phosphate backbone of DNA, leading to high cytotoxicity. On the other hand, anthraquinone‐fused compounds such as daunomycin and adriamycin can insert into DNA through planar aromatic ring structures, resulting in strong DNA damage. To this end, a series of naphthoquinone‐based enediynes were designed and synthesized by adjusting the type of terminal alkyne to modulate their water solubility and radical generation property. Theoretical calculations suggest that the naphthoquinone‐based enediyne generates radicals through a rearrangement (1,3‐proton transfer) followed by Myers‐Saito cyclization processes, with a much lower activation free energy barrier than Bergman cyclization (24.2 kcal/mol vs 39.8 kcal/mol). Differential scanning calorimetry and electron paramagnetic resonance results showed that naphthoquinone‐based enediynes undergo cycloaromatization at relatively low temperatures, resulting in the generation of highly reactive radical species. The enediynes with optimal water solubility displayed strong DNA cleavage ability at micromolar level and high cytotoxicity towards Hela cells, providing a half‐inhibitory concentration of 8.19 μM.
Copper‐Catalyzed Direct C−H Bond Oxidative Sulfonylation of β‐Alkyl Cyanoalkenes with Sodium Sulfinates
Authors: Jin Junyi , Zhou Kaiyang , Liu Xinxiang , Wang Can , Chen Yunfeng 
Published: July 2023

AbstractA direct C−H bond oxidative sulfonylation of β‐alkyl cyanoalkenes with sodium sulfinates was reported. This transformation involves the use of a copper salt catalyst, along with a catalytic amount of I2 and DMSO as the oxidative system, which provides a straightforward and practical access to various cyanoallyllic sulfones.
Behavioral responses of mantled howler monkeys to neighbor long‐distance vocalizations
Authors: Maya Lastra Natalia , Rangel Negrín Ariadna , Dias Pedro A. D. 
Published: July 2023

AbstractObjectivesLong‐distance vocalizations are used by primates in a variety of contexts and may have different functions. The long‐distance vocalizations of howler monkeys (Alouatta spp.) underlie the spatial regulation of neighboring groups and could be associated with the defense of food resources. Here, we test the hypothesis that the behavioral responses of mantled howler monkeys (A. palliata) to neighbor long‐distance vocalizations are influenced by the potential for range defensibility while accounting for location within the home range and food availability.MethodsWe studied two groups for 13 months and a total of 888 h at La Flor de Catemaco (Mexico). Group 1 had a 92‐ha home range and Group 2 had a 24‐ha home range. We recorded vocalizations (N = 178 calls) and movements (N = 74 movements) of focal groups following long‐distance vocalizations produced by their neighbors.ResultsMovement responses, but not vocal responses, were predicted by range defensibility, location, and food availability. As predicted, the group living in the smaller and more defendable range showed stronger movement responses than the group in the larger home range. These movement responses had a shorter latency and longer duration in more valuable spatial and temporal contexts (i.e., the core area and during periods of low food availability).ConclusionsThese results suggest that the tradeoff between the costs and benefits of range defense varies according to the interactions between home range size and both the spatial (core areas) and temporal (food availability) abundance of resources. Thus, the responses of mantled howler monkeys to neighbor long‐distance vocalizations could be related to home range defensibility.
Unravelling the Superiority of Nonbenzenoid Acepleiadylene as a Building Block for Organic Semiconducting Materials**
Authors: Fu Lin , Liu Pengcai , Xue Rui , Tang Xiao‐Yu , Cao Jiawen , Yao Ze‐Fan , Liu Yuchao , Yan Shouke , Wang Xiao‐Ye 
Published: July 2023

AbstractAcepleiadylene (APD), a nonbenzenoid isomer of pyrene, exhibits a unique charge‐separated character with a large molecular dipole and a small optical gap. However, APD has never been explored in optoelectronic materials to take advantage of these appealing properties. Here, we employ APD as a building block in organic semiconducting materials for the first time, and unravel the superiority of nonbenzenoid APD in electronic applications. We have synthesized an APD derivative (APD‐IID) with APD as the terminal donor moieties and isoindigo (IID) as the acceptor core. Theoretical and experimental investigations reveal that APD‐IID has an obvious charge‐separated structure and enhanced intermolecular interactions as compared with its pyrene‐based isomers. As a result, APD‐IID displays significantly higher hole mobilities than those of the pyrene‐based counterparts. These results imply the advantages of employing APD in semiconducting materials and great potential of nonbenzenoid polycyclic arenes for optoelectronic applications.
COMPAS: Softwarelösung für komplexe Bauprojekte
Authors: Chen Li , Casas Gonzalo , Kasirer Chen , Van Mele Tom 
Published: July 2023

AbstractIn einem Bauprojekt arbeiten verschiedene Disziplinen wie Architektur, Ingenieurwesen, Fachplanung und ausführende Bauunternehmen zusammen. Für den Entwurf, die statische Berechnung und die Ausführungsplanung werden unterschiedliche Softwarelösungen eingesetzt. Anpassungen im Entwurf und der Planung müssen zeitaufwendig in jeder einzelnen Softwarelösung manuell eingearbeitet werden. Bei komplexen Geometrien und innovativen Bauweisen sind zusätzliche Analysen und Anpassungen erforderlich, was mit heutigen Softwarelösungen kaum realisierbar ist. Für einen effizienten Datentransfer zwischen verschiedenen Softwareumgebungen wurde COMPAS entwickelt, sodass Innovationen im Bauwesen gefördert werden. COMPAS ist eine Open‐Source‐Umgebung, welche unabhängig von kommerziellen Softwarelösungen verwendet werden kann. Es verfügt über eine Geometriedatenbank, flexible Datenstrukturen für unterschiedliche Disziplinen und Algorithmen für Berechnungen wie z. B. Tragwerksanalysen. Es gibt zahlreiche COMPAS‐Erweiterungen für spezifische Anwendungen wie Montageplanung, Holzbau, Roboterfertigung und additive Fertigung. Anfang 2023 wurde der Verein COMPAS gegründet, um die Weiterentwicklung und Ausbildung voranzutreiben.
Novel biomaterial advanced platelet‐rich fibrin plus block for multiple gingival recession
Authors: Mallappa Jayasheela , Patil Leena , Mani Adi Deepika , Gowda Triveni M. 
Published: July 2023

AbstractBackgroundThe study was aimed to assess and compare hard and soft tissue augmentation clinicoradiographically with and without advanced platelet‐rich fibrin + (A‐PRF+) block for the treatment of multiple gingival recession using vestibular incision subperiosteal tunnel access (VISTA).MethodsA total of 24 patients, exhibiting multiple Miller's Class I or II recessions in the maxillary esthetic zone were included. Participants were divided into two groups, Group 1 was treated with VISTA & A‐PRF+ block whereas Group 2 was with VISTA technique alone. Clinical parameters probing depth, width of keratinized gingiva, gingival biotype, recession depth, and clinical attachment level were recorded at baseline and the end of 6 months. The radiographic cone beam computed tomography measurements of labial plate thickness were taken at baseline and 6 months postoperatively.ResultsFrom baseline to 6 months both the groups showed a clinical and statistical improvement in the parameters. However, a statistically significant difference between the treatment modalities was not observed. In the inter‐group comparison radiographically, labial plate thickness was statistically significant at the end of 6 months when compared to the baseline.ConclusionA‐PRF+ block along with the VISTA technique can be an alternative effective root coverage procedure for the management of multiple gingival recessions in the maxillary esthetic zone.Key pointsWhy is this study new information?To the best of our knowledge, this is the first study using advanced platelet‐rich fibrin plus block for the treatment of multiple gingival recession with a thin labial plate.What are the keys to the successful management of these types of cases?Minimally invasive vestibular incision subperiosteal tunnel access technique, and avoidance of second surgical site morbidity are important factors for treatment and for patient compliance.What are the primary limitations of this study?Short study duration, small sample size, and no histological correlation can be considered as limitations of the study.
Particle Size Distribution Model Fitting and Goodness‐of‐Fit Evaluation
Authors: Mao Haifang , Wang Chaoyang , Liu Jibo , Liu Kejia , Zheng Wei , Tang Ting , Jin Miaomiao 
Published: July 2023

AbstractSix mathematical models were selected for the fitting and regression of the particle size distribution (PSD) of (α,Z)‐2‐amino‐α‐(methoxyimino)‐4‐thiazole‐ethanethioic acid S‐2‐benzothiazolyl ester (MAEM). The goodness‐of‐fit was evaluated by comparing the evaluation indexes such as R2, Akaike's information criterion (AIC), and root mean square error (RMSE). The top three selected models were further applied and compared for the PSD of MAEM produced under two different stirring speeds with distinct differences in regression coefficients. In addition, FBRM monitored the particle number trends on a lab scale under these stirring speeds. Finally, a feasible reaction mechanism was presented in which the dissolution of reactants was the rate‐controlling step which could explain the significant influence on stirring speed.
Mn(II) Polypyridyl Complexes: Precursors to High Valent Mn(V)=O Species and Inhibitors of Cancer Cell Proliferation
Authors: Arora Pragya , Gupta Sikha , Kumari Vechalapu Sai , Kumar Rakesh , Awasthi Ayushi , Senthil Sathyapriya , Khanna Shweta , Allimuthu Dharmaraja , Draksharapu Apparao 
Published: July 2023

AbstractThe reaction of [(L)MnII]2+ (L = neutral polypyridine ligand framework) in the presence of mCPBA (mCPBA = m‐Chloroperoxybenzoic acid) generates a putative MnV=O species at RT. The proposed MnV=O species is capable of performing the aromatic hydroxylation of Cl‐benzoic acid derived from mCPBA to give [(L)MnIII(m‐Cl‐salicylate)]+, which in the presence of excess mCPBA generates a metastable [(L)MnV(O)(m‐Cl‐salicylate)]+, characterized by UV/Vis absorption, EPR, resonance Raman spectroscopy, and ESI‐MS studies. The current study highlights the fact that [(L)MnIII(m‐Cl‐salicylate)]+ formation may not be a dead end for catalysis. Further, a plausible mechanism has been proposed for the formation of [(L)MnV(O)‐m‐Cl‐salicylate)]+ from [(L)MnIII(m‐Cl‐salicylate)]+. The characterized transient [(L)MnV(O)‐m‐Cl‐salicylate)]+ reported in the current work exhibits high reactivity for oxygen atom transfer reactions, supported by the electrophilic character depicted from Hammett studies using a series of para‐substituted thioanisoles. The unprecedented study starting from a non‐heme neutral polypyridine ligand framework paves a path for mimicking the natural active site of photosystem II under ambient conditions. Finally, evaluating the intracellular effect of Mn(II) complexes revealed an enhanced intracellular ROS and mitochondrial dysfunction to prevent the proliferation of hepatocellular carcinoma and breast cancer cells.
PROTOCOL: Do hospital leadership styles predict patient safety indicators? A systematic review
Authors: Buttigieg Sandra C. , Riva Nicoletta , Tomaselli Gianpaolo , Said Emanuel , Grech Elaine , Cassar Vincent 
Published: July 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: The main aim of this systematic review is to identify whether hospital leadership styles predict patient safety as measured through several indicators over time. The second aim is to assess the extent to which the prediction of hospital leadership styles on patient safety indicators varies as a function of the leader's hierarchy level in the organization.
Studying Molecular Rearrangement of P1 Dye at a Passivating Alumina Surface Using Vibrational Sum‐Frequency Generation Spectroscopy: Effect of Atomic‐Level Roughness
Authors: De Ratnadip , Bera Anupam , Schmidt Heiner , Neumann Christof , Paa Wolfgang , Gawlik Annett , Turchanin Andrey , Dietzek‐Ivanšić Benjamin 
Published: July 2023

AbstractThe effect of roughness and thickness of alumina layers, mimicking the passivation layer commonly used in dye‐sensitized photoelectrodes, on the molecular adsorption of P1 dye, 4‐(bi(4‐(2,2‐dicyano‐vinyl)‐thiophene‐2‐yl]‐phenyl]‐aminobenzoic acid) has been studied using surface‐sensitive vibrational sum frequency generation(VSFG) spectroscopy. The VSFG spectra reveal the formation of poorly ordered dye layers on relatively rough surfaces where XPS measures a higher dye loading. Furthermore, these poorly ordered dye molecules are responsible for the generation of trapped electronic states as probed by successive photoluminescence (PL) measurements. Surface sensitive VSFG spectroscopy in combination with XPS and PL measurements provide complementary spectral information on ordering of the adsorbed dyes, their density on the surface and electronic states of the adsorbed monolayer which are prerequisite for improving our understanding of molecularly functionalized photoelectrodes and their further development.
Are dental visiting patterns and oral pain associated with dental disease among Norwegian adults? A cross‐sectional study based on the Tromsø study
Authors: Nermo Hege , Hadler‐Olsen Elin 
Published: July 2023

AbstractObjectivesThe present study aims to describe the dental visiting patterns in a Norwegian adult population and their associations with sociodemographic and oral health variables, including oral pain. We further explore if the utilization of dental health services and oral pain predicts caries and periodontitis, the most common oral diseases.Materials and MethodsWe use data from the seventh wave of the Tromsø study performed in 2015–2016. In this cross‐sectional survey, all residents 40 years or older in Tromsø municipality in Norway were invited, of whom 21,083 (65%) participated. All participants answered questionnaires assessing sociodemographic characteristics, use of health services, and self‐reported health measures, including pain. Almost 4000 participants underwent a dental examination with registration of caries and periodontitis. Associations of dental visiting patterns and utilization of dental services the past 12 months with sociodemographic‐, self‐reported‐, and clinical oral health measures were analyzed by cross‐tabulation and Pearson's χ2 tests, as well as with logistic regression analyses with caries and periodontitis as outcomes.ResultsA regular, annual dental visiting pattern was the most common, but among respondents with severe dental anxiety and poor dental health, visiting for acute problems only or never (symptomatic visiting) was the most common. Intervals of more than 24 months between visits and a symptomatic visiting pattern were associated with caries, whereas shorter than 12‐month intervals and a symptomatic visiting pattern were associated with periodontitis. Many characteristics were shared among respondents with the lowest and the highest utilization of dental services, including oral pain, a difficult financial situation and poorer self‐reported and clinical dental health.ConclusionsRegular dental visits at 12–24 month intervals were associated with beneficial oral health parameters, compared with more frequent, rarer, and symptomatic dental visiting patterns. Oral pain was an unreliable predictor of caries and periodontitis.