bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effect of Triclosan in Monocrotaline-Induced Pulmonary Arterial Hypertension
Authors: Alsabeelah Nimer , Kumar Vinay 
Published: February 2023

Background:
Novel pharmacological approaches are needed to improve the outcomes of patients with idiopathic pulmonary hypertension. Fatty acid synthase (FASN) inhibitors have shown beneficial effects in preclinical models of pulmonary arterial hypertension (PAH), because of their role in the regulation of pulmonary artery vasoconstrictor tone and remodeling.

Objective:
We compared a Triclosan (FASN inhibitor), for the first time with the dual endothelin receptor antagonist, macitentan, in a monocrotaline-induced rat pulmonary hypertension model

Methods:
Different methods (hemodynamics, histology of right ventricle and pulmonary vessels, and circulating biomarkers) showed consistently that 30 mg/kg daily of Triclosan (FASN inhibitor) and 10 mg/kg daily of macitentan slowed the progression of PAH both at the functional and structural levels.

Results:
Treatments started on day 14 after monocrotaline injection and lasted 14 days. The findings of all experimental methods show that the FASN inhibitor has more similar effects as compared to macitentan.

Conclusion:
Our study reveals that inhibition of FAS decreases RV hypertrophy and improves cardiac function associated with PAH with the regulation of metabolic functions and governs further studies to establish “FASN inhibitor as a potential therapeutic approach” for the management of PAH.
The International Standards for Neurological Classification of Spinal Cord Injury: Classification Accuracy and Challenges
Authors: Snider Brittany A. , Eren Fatma , Reeves Ronald K. , Rupp Rüdiger , Kirshblum Steven C. 
Published: February 2023

Background
Successful utilization of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) requires a comprehensive understanding of its rules, terminology, and several complex concepts. There have been no studies investigating classification accuracy since the newest ISNCSCI revision (2019).

Objectives
To evaluate classification accuracy of SCI professionals using the 2019 ISNCSCI edition, identify common mistakes and areas of confusion, and assess associations between experience in ISNCSCI classification and performance.

Methods
Members of the International Spinal Cord Society (ISCoS) and attendees of the ISCoS Annual Scientific Meeting 2021 were invited to complete an online survey that included six ISNCSCI cases to classify.

Results
A total of 107 persons completed the survey, with overall classification accuracy of 74.6%. Accuracy was highest for injury completeness (95.3%) and sensory level (91.1%) and lowest for motor zone of partial preservation (ZPP; 54.7%) and ASIA Impairment Scale (AIS) grade (57.3%). Newer concepts, including the appropriate documentation of non-SCI conditions and classification of ZPP in incomplete injuries, contributed to several common errors. There was a significant association between overall classification accuracy and self-rated experience in the ISNCSCI classification (p = .017). Experience with the ISNCSCI examination, experience in SCI medicine, and occupation were not found to be significantly associated with overall classification accuracy.

Conclusion
Classification accuracy of an international cohort of SCI professionals was modest but greater than previous reports. Knowledge deficits about the 2019 ISNCSCI updates are prevalent and contribute to common classification errors. Further training in the utilization of the ISNCSCI is needed.
Effect of Stemming on Hindi Text Classification
Authors: Pimpalshende Dr. Anjusha , SINGH PREETY , Potnurwar Dr. Archana 
Published: February 2023

Abstract. Text classification is very useful to search large amount of textual data available online by dividing it into smaller relevant units. Now a day’s large amount of digital documents are available in Indian languages. Designing text classifiers in Indian languages is one of the research areas so that people can search and read required documents in their local languages. In proposed work tried to design Text classifier for Hindi text documents and tried to show how stemmer affects the performance of Hindi text classifiers. Stemming is a process to convert words in any language to its base or root words. Stemmers are used for written documents not for spoken languages. Performance of many applications such as text summarization, Information Retrieval (IR) system,text classification systems, syntactic parsing can be improved by applying stemmers. Stemmer eliminates suffix or prefix of the word and form original root word. These root words helps in the preprocessing step required in many algorithms. We applied various stemmers on Hindi text classification models. Experiments and results show that performance of the classifiers is improved by applying stemmers.
Impactos do mundo do trabalho na supervisão de estágio em Serviço Social
Authors: Lopes Gessica dos Santos Machado , Lewgoy Alzira Maria Baptista 
Published: February 2023

O artigo tem por objetivo trazer à reflexão os impactos, as tendências e os desafios do estágio e da supervisão em Serviço Social, provenientes do mundo do trabalho, na Região Sul do Brasil. O estudo é fruto de pesquisa bibliográfica nos Anais dos Encontros Nacionais de Pesquisadores em Serviço Social e dos Congressos Brasileiro de Assistentes Sociais e de pesquisa de campo junto às coordenações de estágio do curso de Serviço Social das Unidades de Formação Acadêmica e das Comissões de Orientação e Fiscalização Profissional dos Conselhos Regionais de Serviço Social. As reconfigurações do mundo do trabalho interferem no estágio e na supervisão, considerando o aligeiramento da formação profissional, intensificadas por flexibilização e precarização das condições de trabalho, fomentada por terceirização, rotatividade de profissionais, empobrecimento intelectual e parca apropriação da competência profissional.
Palavras-chave: Serviço Social. Supervisão de Estágio. Mundo do Trabalho. Formação e Trabalho Profissional.
Изучение факторов, влияющих на развитие первичной дисменореи
Authors: Мусозода Дурдона , Ахмедова Нилюфар 
Published: February 2023

Первичная дисменорея — это циклически повторяющийся болевой синдром, который обусловлен комплексом нейровегетативных, обменных и поведенческих нарушений, сопровождающих менструальное отторжение эндометрия. Возникает непосредственно с момента менархе, либо через несколько лет после установления менструального цикла. Обычно имеет функциональный характер, не связанная с патологией внутренних органов.
The Satisfaction of Civil Servants Civil Service Agency and Human Resources Development (BKPSDM) Bone Bolango Regency Through the Employee Welfare Program
Authors: Husain Meylan , Syamsinah  , Rachman Ayu Anatasya 
Published: February 2023

The current study aims 1) To identify and analyze the welfare program made by the government, especially the regional Government of Bone Bolango Regency at the Agency for Personnel and Human Resources Development of Bone Bolango Regency. 2) It also aims to find out and analyze the Saticfaction of the State Civil Apparatus Agency for Human Resources and Development of Bone Bolango Regency through the Employee Welfare Program.
The method in this study uses descriptive qualitativ methods with interview and documentation data collection terchniques.
The study results show that 1) welfare programs in the Staffing and Resource Development Agency of Bone Bolango Regency are in the form of Job Allowances, Employment BPJS Benefits, and Additional Employee Income Benefits (TPP). It also provides leave facilities work facilities that are adjusted to the class or position of each employee. 2) The Satisfaction of Civil Servants at the Personnel and Human Resources Development Agency of Bone Bolango Regency are already satisfied with the provision of a welfare program in the form of a salary adjusted to the class or position given by the Government every month in the form of a basic salary that does not experience deductions. It also provides allowances given according to the regulations set by the Government. In addition, employees will be given an award and work facilities to motivate employees to improve performance further.
Effects of moderate exercise versus light exercise on fasting blood glucose in obese patients with type 2 diabetes mellitus
Authors: Youssef Manal Kamel 
Published: February 2023

IntroductionDiabetes is an important cause of mortality throughout the world. Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and obesity, which are aggravated by a sedentary lifestyle. The consequences of long-term hyperglycemia include neurological or vascular complications and can lead to amputation, retinopathy, kidney failure, or other severe complications and a consequently poor quality of life. This study was conducted to report the effect of moderate exercise versus light exercise on fasting blood glucose in obese patients with T2DM.MethodsFor three months, 60 patients with sedentary lifestyles aged 35 to 60 years were randomly assigned to one of two groups in this two-arm cluster randomized controlled trial. Group 1 received 30 minutes of treadmill walking at 40–60% of maximum heart rate. Group 2 was given 30 minutes of treadmill walking per day, divided into 5 minutes every 2 hours.ResultsAt the base line, no significant difference was found between both groups in BMI, waist to hip ratio, 6-minutes’ walk, fasting blood glucose and SF-36. After three months of treatment, there was no significant difference in BMI, <i>p</i> = 0.111, waist to hip ratio, p = 0.271, 6 minutes’ walk, <i>p</i> = 0.614, blood glucose, <i>p</i> = 0.105, and SF-36, <i>p</i> = 0.106 between the two groups, despite the fact, that among each group significant differences for all analyzed parameters were observed.ConclusionsRepeated short walking has a similar effect on blood glucose, obesity, and quality of life as continuous long walking. Walking for 5 minutes every 2 hours may be a useful alternative for patients with T2DM.
NGHIÊN CỨU SỰ BIẾN ĐỔI ĐỘ ĐÀN HỒI THẤT TRÁI Ở BỆNH NHÂN BỆNH TIM THIẾU MÁU CỤC BỘ MẠN TÍNH
Authors: Phạm Vũ Thu Hà , Lương Công Thức 
Published: February 2023

Mục tiêu: Khảo sát chỉ số độ đàn hồi thất trái cuối tâm thu (Ees) (Left ventricular end systolic elastance), độ đàn hồi thất trái cuối tâm trương ở bệnh nhân bệnh tim thiếu máu cục bộ mạn tính. Đối tượng và phương pháp: 129 bệnh nhân được chẩn đoán bệnh tim thiếu máu cục bộ mạn tính và 40 người được chụp động mạch vành bình thường, tham gia nghiên cứu từ 12/2016 đến tháng 12/2018. Tính chỉ số Ees bằng phương pháp đơn nhịp trên siêu âm tim. Ed được tính bằng công thức (E/e’)/ SV (1/ml). Kết quả: Giá trị trung vị của Ees ở nhóm bệnh tim thiếu máu cục bộ mạn tính lần lượt là 3,87 (2,88 – 4,97) (mmHg/ml) thấp hơn so với nhóm chứng (4.38 ( 3.70 – 5.29) mmmHg/ml) trong khi Ed giữa 2 nhóm không có sự khác biệt. Ees, Ed có mối liên quan với tuổi, giới và tình trạng suy tim. Ees của nhóm suy tim (2,59 (1,83 – 4,09) mmHg/ml) thấp hơn nhóm không suy tim (4,08 (3,17 – 5,26) mmHg/ml). Trong khi Ed của nhóm suy tim (0,28 (0,19 – 0,39) 1/ml) cao hơn nhóm không suy tim (0,24 (0,17 – 0,31) 1/ml). Ees giảm dần khi phân độ suy tim theo NYHA tăng dần (p < 0,05) nhưng Ed thì không có mối liên quan với mức độ suy tim. Kết luận: Ees ở BN BTTMCBMT thấp hơn còn Ed cao hơn có ý nghĩa so với nhóm chứng. Ees, Ed có mối liên quan với tuổi và giới. Ees, Ed có liên quan đến tình trạng suy tim. Ees giảm dần khi mức độ suy tim theo NYHA nặng dần nhưng Ed thì chưa nhận thấy mối liên quan này.
TÌNH TRẠNG TỔN THƯƠNG GAN DO DỊ ỨNG THUỐC TẠI BỆNH VIỆN ĐÀ NẴNG
Authors: Trần Thị Phương Chi , Hoàng Thị Lâm 
Published: February 2023

Mục tiêu: Đánh giá tình trạng tổn thương gan của bệnh nhân dị ứng thuốc tại Bệnh viện Đà Nẵng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang và hồi cứu trên 444 bệnh nhân bị dị ứng thuốc từ tháng 1/2018 đến 5/2022 tại Bệnh viện Đà Nẵng. Kết quả: Tuổi trung bình của đối tượng nghiên cứu là 45,68 ± 16,85 tuổi, lớn nhất là 86 tuổi, nhỏ nhất là 15 tuổi. Có 19,9% và 22,3% bệnh nhân dị ứng thuốc có tăng SGOT và SGPT trên giới hạn trên bình thường. Nồng độ SGOT và SGPT trung bình của nhóm bệnh nhân nghiên cứu là 33,76 ± 45,15 U/L và 38,70 ± 55,65 U/L. Hội chứng DRESS có tổn thương gan nặng nhất với SGOT trung bình là 182,06 ± 88,53 (U/L) và SGPT trung bình là 364,73 ± 171,01 U/L. Có rất nhiều loại thuốc gây ra tổn thương gan trong đó hai loại thuốc gây tăng men gan nhiều nhất là thuốc kháng lao (SGOT: 104,45 ± 90,43 U/L; SGPT: 170,35 ± 256,0 U/L) và allopurinol (SGOT: 134,35 ± 188,71 U/L; SGPT: 147,24 ± 112,98 U/L). Các thể tổn thương da nặng (Hội chứng Lyell, SJS, DRESS, đỏ da toàn thân) đều có albumin máu trung bình thấp < 35 g/L. Kết luận: Tổn thương gan là tổn thương thường gặp ở bệnh nhân dị ứng thuốc trong đó hội chứng DRESS là thể lâm sàng gây tổn thương gan nặng nhất. Thuốc kháng lao, allopurinol là những thuốc gây tổn thương gan nặng nhất. Albumin máu ở những thể dị ứng thuốc nặng thường thấp < 35g/L.
KAPASITAS BIROKRASI DALAM MENGUNAKAN APLIKASI BERBASIS DIGITALISASI DALAM MENINGKATKAN SUMBER DAYA MANUSIA DI PEMERINTAHAN DAERAH
Authors: Rohmadi Denizar Putra Handa , Idrus Iqbal Aidar 
Published: February 2023

Pelayanan berbasis digitalisasi sangat membantu pelaksanaan kinerja birokrasi dan meningkatkan SDM dalam memahami pengelolaan digitaisasi di pemerintahan. Sejalan dengan itu , otoritas pemerintah harus dapat memperluas dominasi informasi teknologi dan SDM yang berimajinatif serta mengharapkan berbagai masalah formal dan kasual dengan menggunakan inovasi cerdas yang umumnya digunakan di ruang publik, untuk memperkuat efisiensi kerja. Untuk memahami birokrasi yang cepat dan sigap dalam menawarkan jenis bantuan publik, diperlukan perubahan mendasar. Selain itu, keselarasan perubahan peraturan harus dipertahankan untuk bekerja pada sifat administrasi publik dan memberikan kepercayaan publik pada otoritas pemerintah, sehingga bagian dari bantuan publik terkait SDM dengan perubahan peraturan. inovasi, serta peningkatan administrasi dan otoritas. Proses administrasi elektif yang layak, mengenai ilmu birokrasi teknologi efektif dan lugas adalah kerangka pemerintahan elektronik dengan perspektif granular. Merencanakan perbaikan dengan menitik beratkan pada pelatihan dan persiapan, perubahan dan kemajuan, serta mengisi lowongan yang membutuhkan tenaga ahli berpengalaman dengan menggunakan inovasi merupakan suatu siklus yang merupakan bagian penting dari perencanaan SDM dan sikap mental yang tidak tertandingi dalam perangkat SDM pemerintahan daerah itu sendiri.
Applying the (1,2)-pitchfork domination and it's inverse on some special graphs
Authors: Abdlhusein Mohammed Abdali 
Published: February 2023

Let G be a finite simple and undirected graph without isolated vertices. For any non-negative integers j and k, a subset D of V is called a pitchfork dominating set if every vertex in D dominates at least j and at most k vertices of V - D. A subset D -1 of V - D is an inverse pitchfork dominating set if it is a dominating set. The pitchfork domination number of G, denoted by pf (G) is a minimum cardinality over all pitchfork dominating sets in G. The inverse pitchfork domination number of G, denoted by pf-1 (G) is a minimum cardinality over all inverse pitchfork dominating sets in G. In this paper, pitchfork dominations and it's inverse are applied when j = 1 and k = 2 on some standard graphs such as: tadpole graph, lollipop graph, lollipop flower graph , daisy graph and Barbell graph.
The Efficacy and Tolerability of a Fixed Combination of Perindopril and Indapamide in the Treatment of Unregulated Essential Hypertension – a Postmarketing Study
Authors: Šukalo Aziz , Džananović Jaganjac Jasna , Tanović Avdić Amna , Glamočlija Una , Popović Željka , Boloban Alis , Tirić Čampara Merita , Mehić Meliha 
Published: February 2023

Objective. The objective of this non-interventional post-marketing clinical trial was to analyze the antihypertensive effect and safety of a fixed combination of perindopril and indapamide in the treatment of unregulated essential hypertension.
Patients and Methods. The prospective clinical trial included patients aged 20 to 75 years with essential hypertension and blood pressure values ≥ 140/90 mmHg at baseline. On the basis of the investigator’s decision, patients received 2 mg perindopril + 0.625 mg indapamide (group 2+0.625) or 4 mg perindopril + 1.25 mg indapamide (group 4+1.25).
Results. The study included 1173 patients (426 patients in group 2+0.625 and 747 patients in group 4+1.25) at 27 investigational centers in Bosnia and Herzegovina. Mean blood pressure values at baseline and visits after nine months were significantly higher in the 4+1.25 group compared to the 2+0.625 group. There was a significant drop in systolic and diastolic blood pressure in both groups. The target values of systolic and diastolic blood pressure, according to the European Society of Cardiology (2018), were reached after nine months of therapy by more than 80% of patients in the 2+0.625 group, and this number was significantly higher compared to the 4+1.25 group where more than 60% of patients reached target values. Newly diagnosed patients had a better response to therapy. The percentage of patients receiving additional antihypertensive therapy decreased by the end of the study. Age, gender and the existence of diabetes mellitus were identified as negative predictors of target blood pressure achievement. The therapy showed a good safety profile.
Conclusion. A fixed combination of perindopril and indapamide was effective and safe in the treatment of unregulated essential hypertension.
Endoscopıc Anatomy of the Lacrımal Sac: A Cadaverıc Study
Authors: Ozcelik Erdem Rukiye , Dundar Mehmet Akif , Arbag Senanur , Arbag Hamdi , Seker Muzaffer 
Published: February 2023

Objective. To describe the anatomy of the lacrimal sac in relation to the lateral nasal wall by cadaver dissection, and to measure the distances of surgically important landmarks from relevant structures for safer and more efficient surgery.
Method. A total of 12 endoscopic dacryocystorhinostomy (DCR) were performed on both sides (right and left) of 6 fresh-frozen cadavers. The distances of the lacrimal sac to the posterior edge of the uncinate process, the frontal process of the maxilla, the maxillary ostium, the nasal vestibule, the middle turbinate attachment and the inferior turbinate were measured. In addition, the width and length of the lacrimal sac were measured.
Results. The mean width and length of the lacrimal sac were 5.6 mm and 11.1 mm, respectively. The lacrimal sac was located at 15.2 mm from the posterior edge of the uncinate process, at 35.5 mm from the nasal vestibule, at 13.5 mm from the maxillary ostium, at 12.2 mm from the frontal process of the maxilla, at 8.7 mm from the middle turbinate attachment, and at 7.3 mm from the inferior turbinate.
Conclusion. This study provides additional measurements regarding the lacrimal sac and its relationships with nearby landmarks for use in endoscopic dacryocystorhinostomy. The distances of the lacrimal sac to the nasal vestibule, the uncinate process and the frontal process of the maxilla are not as reliable as the middle turbinate attachment for predicting the anatomic localization of the lacrimal sac during DCR.
The Prevalence and Morphometry of the Atlas Vertebra Retrotransverse Foramen
Authors: Lyrtzis Christos , Tsakotos George , Kostares Michael , Piagkou Maria , Mariorakis Chrysovalantis , Natsis Konstantinos 
Published: February 2023

Objective. The current study records the prevalence of the accessory foramen, located posterior to the transverse foramen (TF), the so-called the retrotransverse foramen (RTF), its morphometry, exact location, and coexistence with ossified posterior bridges. Additionally, factors associated with the length of the RTF are investigated.
Materials. One-hundred and forty-one dried atlas vertebrae were examined.
Results. Thirty-seven out of the 141 vertebrae (26.2%) had at least one RTF. The RTF was unilateral in 67.6% and bilateral in 32.4%. The mean RTF anteroposterior diameter (length) was 4.2±1.4 mm on the right and 3.8±1.0 mm on the left side. The mean RTF laterolateral diameter (width) was 2.6±1.2 mm on the right and 2.5±0.8 mm on the left side. Both dimensions were symmetrical. The RTF was symmetrically located from the TF, at a mean distance of 4.6±1.1 mm on the right and of 4.5±0.9 mm on the left side. For the given TF-RTF distance, laterality, and presence of posterior bridges, each mm increase in the RTF width was associated with a 0.74 mm increase in the relevant length.
Conclusion. The estimated prevalence was higher than most of those reported in other studies. However, the between-studies prevalence varies to a significant degree. Hence, a systematic review and meta-analysis should be performed to identify a more precise estimate due to the clinical importance of the RTF.
High Flow Nasal Cannula Versus Noninvasive Positive Pressure Ventilation as Initial Respiratory Support in Patients with Chronic Obstructive Pulmonary Disease and Covid-19
Authors: Mujaković Aida , Kovačević Tijana , Begić Edin , Fajkić Almir , Barić Goran , Jamakosmanović Anida , Kovačević Peđa 
Published: February 2023

Objective. To identify the type of the non-invasive ventilatory treatment for patients diagnosed with chronic obstructive pulmonary disease (COPD), with respiratory status deteriorated by COVID-19 pneumonia, and in need of treatment in the Intensive Care Unit (ICU).
Materials and Methods. This cross-sectional study was conducted over a one-year period in the medical intensive care units of two hospitals. As the patients’ clinical condition deteriorated and the parameters of the arterial blood gas (ABG) analysis worsened, oxygen support was applied via a high flow nasal cannula (HFNC) or by non-invasive positive pressure ventilation (NPPV). According to the control values of the arterial oxygen saturation (SaO2) and the parameters of ABG, the patients were enabled to be transferred between the two types of non-invasive ventilatory support. The primary outcome was the length of hospital stay, while secondary outcomes were the rate of intubation, the mortality rate, and respiratory supportfree days.
Results. Out of 21 critical patients with COPD and COVID-19, 11 (52.4%) were initially treated with NPPV and 10 (47.6%) with HFNC. The ages (67±9.79 in NPPV group vs. 70.10±10.25 in HFNC group) and severity of illness (SOFA score 5 (3.5) in NPPV group vs. 5 (2.8) in HFNC group) were similar between the two groups. Switching the mode of respiratory support was more common in NPPV (58.3% in survivor group vs. 41.7% in non-survivor group). Patients treated with NPPV compared to HFNC had a nominally longer length of stay (15 (11) vs. 11.5 (4.25)), and higher risk of intubation (66.7% vs. 33.3%) and mortality (66.7% vs. 33.3%), but the comparisons did not reach statistical significance. Survivors had significantly longer Medical Intensive Care Unit and hospital stays, but significantly lower FiO2 (0.60 vs.1) and higher values of PaO2 /FiO2 (78(32.4) vs. 56.3(17.8)) than non-survivors. All patients were treated with corticosteroids, and the duration of treatment was similar between groups.
Conclusion. In critically ill patients with COPD and COVID-19, both HFNC and NPPV were commonly used as the initial mode of ventilation. Switching to a different mode and adverse patient outcomes were more frequent in patients initially treated with NPPV. Survivors had higher values of PaO2 /FiO2 than non-survivors.