bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Pharmacogenomics Polymorphism and Non- Genetics Factors on Allopurinol-Induced Cutaneous Adverse Drug Reactions in Thai Patients Running title: Genetics of Allopurinol-induced CADRs in Thais
Authors: Sornsamdang Gaidganok , Satapornpong Patompong , Jinda Pimonpan , Jantararoungtong Thawinee , Koomdee Napatrupron , Tempark Therdpong , Klaewsongkram Jettanong , Rerkpattanapipat Ticha , Rerknimitr Pawinee , Tuchinda Papapit , Chularojanamontri Leena , Tovanabutra Napatra , Chanprapaph Kumutnart , Disphanurat Wareeporn , Chakkavittumrong Panlop , Srisuttiyak Chutika , Srinoulpras Yuttana , John Shobana , Biswas Mohitosh , Sukasem Chonlaphat 
Published: May 2023

Abstract
Allopurinol is causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs). The goal of this study was to identify genetic biomarkers of single nucleotide polymorphisms (SNPs) for allopurinol induced cADRs among Thai patients. We conducted a case-control association study after enrolling 57 Thai patients with allopurinol induced cADRs and 101 allopurinol tolerant controls. Genetic biomarkers and associated SNPs located on chromosome 6p21 were examined by TaqMan® SNP genotyping assays in both case and controls. Out of 15 SNPs in nine genes, four combined SNPs (rs3099844 of HCP5; rs9263726 of PSORS1C1; rs9263733 of POLR2LP and rs9263745 of CCHCR1) were significantly associated with allopurinol induced cADRs compared to tolerant controls (OR 3.2; 95% CI 24.2-266.8; P = 1.9x10− 24). Overall sensitivity, specificity, positive predictive value and negative predictive value of these combinations were 84%, 94%, 9% and 100%, respectively. The SNPs were not in absolute linkage disequilibrium with HLA-B*58:01, however, the variant alleles of these SNPs combination were detected in 89.5% (51/57) of the cases. The findings suggest that these SNPs could be used as an alternative novel biomarker in predicting cADRs in patients taking allopurinol especially in those with absence of HLA-B*58:01 allele but still experiencing cADRs.
Study on the thermal kinetics and microscopic characteristics of oxidized coal
Authors: Wang Wei , Zhu Hongqing , Huang Hong , Zhao Hongru , Pan Rongliang 
Published: May 2023

Abstract
Revealing the characteristics of spontaneous combustion and re-combustion of oxidized coal is of great significance for the coal fire prevention and control. Synchronous Thermal Analyzer (STA) and Fourier Transform Infrared Spectrometer (FTIR) were used to measure the thermal kinetics and microscopic characteristics of coal samples with different oxidation degrees (unoxidized, 100 ℃, 200 ℃ and 300 ℃ oxidized coal). It is found that the characteristic temperatures decrease first and then increase with the increasing degree of oxidation. The ignition temperature of 100 ℃-O coal (oxidized at 100 ℃ for 6 h) is relatively the lowest at 334.1 ℃. Pyrolysis and gas-phase combustion reactions dominate the weight loss process, while solid-phase combustion reactions are relatively minor. The gas-phase combustion ratio of 100 ℃-O coal is the highest at 68.56%. With the deepening of coal oxidation degree, the relative content of aliphatic hydrocarbons and hydroxyl groups gradually decreases, while that of oxygen-containing functional groups (C-O, C = O, COOH, etc.) increases first and then decreases, reaching the highest value of 42.2% at 100 ℃. Moreover, the 100 ℃-O coal has the minimum temperature at the point of maximum exothermic power of 378.5 ℃, the highest exothermic power of -53.09 mW/mg and the maximum enthalpy of -18579 J/g. All results show that 100 ℃-O coal has the highest risk of spontaneous combustion than the other three coal samples. This suggests that there is a maximum point of spontaneous combustion risk in the range of pre-oxidization temperatures of oxidized coal.
An assessment of WRF-Urban schemes in simulating local meteorology for heat stress analysis in a tropical Sub-Saharan African city, Lagos, Nigeria
Authors: Obe Oluwafemi Benjamin , Morakinyo Tobi Eniolu , Mills Gerald 
Published: May 2023

Abstract

Urban areas, such as Lagos, Nigeria, face significant challenges due to rapid urbanization and climate change, resulting in a higher intensity of the urban heat island effect, coupled with high population density, making the city fall under the category of moderate to high heat stress/risk. Despite this, very few studies have analysed the urban impact on heat stress over the coastal city, albeit with poor resolution data. In this study, we assessed the performance of an integrated high-resolution WRF-urban scheme driven by the readily available urban canopy information of the Local Climate Zone (LCZ) to simulate local meteorological data for analysing the spatiotemporal pattern of heat stress over the megacity. Our results show that the WRF-BEP scheme outperformed the other evaluated urban schemes, reducing the Normalized Root Mean Squared Error by 25%. Furthermore, we found a generally high incidence of intense discomfort in highly urbanized areas and noted the significant influence of urban morphology on the pattern of heat stress, particularly at night due to the combined effect of urban warming and higher relative humidity. The most socioeconomically disadvantaged urban areas, LCZ7, were most affected, with ‘hot’ heat stress conditions observed over 90% of the time. However, during the afternoon, our result highlights the role of the advection of cold sea breeze in reducing heat stress in highly urbanized areas. Our findings would be relevant in the development of the urgently needed climate/heat adaptation plans for the city and other sub-Saharan African cities.
Unlocking opioid neuropeptide dynamics with genetically-encoded biosensors
Authors: Tian Lin , Dong Chunyang , Gowrishankar Raajaram , Jin Yihan , He Xinyi , Gupta Achla , Wang Huikun , Atasoy Nilüfer , Flores-Garcia Rodolfo , Mahe Karan , Liang Ruqiang , Or Grace , Lo Darren , Sun Qingtao , Whistler Jennifer , Li Bo , Gomes Ivone , Tejeda Hugo , Atasoy Deniz , Devi Lakshmi , Bruchas Michael , Banghart Matthew 
Published: May 2023

Abstract

Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental tools that allow for the precise dissection of their complex and diverse dynamics in a circuit-specific manner. Opioid peptides comprise a clinically relevant family that modulates pain, reward, and aversion. To illuminate the spatiotemporal dynamics of endogenous opioid signaling in the brain, we developed a class of genetically-encoded fluorescent sensors based on kappa, delta, and mu opioid receptors: κLight, δLight, and µLight, respectively. We used κLight to identify electrical stimulation parameters that trigger endogenous opioid release and the spatiotemporal scale of dynorphin volume transmission ex vivo. Using in vivo fiber photometry, we characterized optogenetically-driven opioid release, and observed differential opioid signaling in response to fearful and rewarding conditions in the nucleus accumbens. These sensors reveal the dynamics of endogenous opioid neuropeptide release in vivo, in awake freely moving behavior.
Transient response analysis of nonlinear oscillators with fractional derivative elements under Gaussian white noise using complex fractional moments
Authors: Tsuchida Takahiro , Itoh Daizoh , Eguchi Tsubasa 
Published: May 2023

Abstract
An approximate analytical approach using complex fractional moments (CFMs) is developed for determining the transient response　probability density of nonlinear oscillators with fractional derivative elements under Gaussian white noise. The CFM is defined as the Mellin transform of a probability density function. The system response is represented in the form of a pseudo-harmonic oscillation with amplitude and phase slowly varying with time. Equivalent linearization is first implemented to obtain an equivalent natural frequency and an equivalent damping coefficient of the oscillator. In this regard, simple formulas for determining them are proposed, in which both the nonlinear elements and the elastic and viscous contributions of the fractional elements are taken into account. Next, applying stochastic averaging, the response amplitude is described by a one-dimensional stochastic differential equation, and the corresponding Fokker-Planck equation is derived. The Mellin transform then converts the Fokker-Planck equation into coupled linear ordinary differential equations governing the evolution of amplitude CFMs, which are solved with a constraint corresponding to the normalization condition for a probability density. Finally, the inverse Mellin transform of the CFMs yields the amplitude probability density. The joint probability density of displacement and velocity is also obtained from the amplitude probability density in conjunction with the Jacobian of the pseudo-harmonic variable transformation for the response. Three linear and nonlinear oscillators with fractional derivatives are considered in numerical examples. For all cases, the analytical results obtained by the proposed method are in good agreement with the results of the pertinent Monte Carlo simulation.
Metachronal Wave Impact in a Channel Flow in the Presence of Prandtl Fluid Model
Authors: Sadaf Hina , Asghar Zeeshan , Iftikhar Naheeda 
Published: May 2023

Abstract
Motile cilia are tiny, hair-like structures originate in many different types of biological processes. They produce directed flow to allow fluid transport. Cilia are important for locomotion and play a dynamic part in animal and human growth and in everyday life. It may help to remove contaminants from organs or tissue by facilitating the flow of fluids over the cell. The intention of our theoretical study is to inspect the physical and computational aspects of applied magnetic field on Prandtl (non-Newtonian) ciliated fluid flow, that moves through a uniform ciliated channel. This flow is the conduct for symmetrical wave circulation and is frequently observed during the expansion and contraction of concentrical cilia. The problem is first formulated mathematically, which results in a highly nonlinear system of PDEs. Equations are transformed into ODEs using a scaling group of transformations. Second, approximation of wavelength is long and Reynolds number is low used to analyze the flow motion caused by metachronal waves. The emerging equation is solved numerically using the bvp4c method. Dimensionless velocity, temperature, pressure rise, and pressure gradient expressions are engendered and graphical comprehensive illustrations of all these in relation to various factors are also provided. Also, streamlines are fabricated to exhibit the flow phenomenon of ciliary motion.
Relationship between comorbidity and health outcomes in patients with heart failure: A systematic review and meta-analysis
Authors: Lee Kyoung Suk , Park Da-In , Lee Jihyang , Oh Oonjee , Kim Nayoung , Nam Gyumi 
Published: May 2023

Abstract
Background: The prevalence of heart failure (HF) is expected to rise due to increased survivorship and life expectancy of patients with acute heart conditions. Patients with HF and other multiple comorbid conditions are likely to have poor health outcomes. This study aimed to assimilate the current body of knowledge and to provide the pooled effect of HF patients’ comorbid conditions on health outcomes.
Methods: A systematic search was performed using MEDLINE, EMBASE and CINAHL databases. Observational studies evaluating the relationship between comorbid conditions and the health outcomes of HF were included. The pooled effect sizes of comorbidity on the identified health outcomes were calculated using a random effects model, and heterogeneity was evaluated using I2 statistics.
Results: A total of 42 studies were included in this review, and a meta-analysis was performed using the results of 39 studies. In the pooled analysis, the presence of a comorbid condition showed significant pooled effect size in relation to the prognostic health outcomes: all-cause mortality (HR 1.31; 95% CI 1.18, 1.45), all-cause readmission (HR 1.16; 95% CI 1.09, 1.23), HF-related readmission (HR 1.13; 95% CI 1.05, 1.23), and non-HF-related readmission (HR 1.17; 95% CI 1.07, 1.27). Also, comorbidity was significantly associated with self-care confidence. Furthermore, we identified 10 individual comorbid conditions that have negative effects on overall prognostic outcomes: DM (HR 1.16, 95% CI 1.11, 1.22, p< 0.001), COPD (HR 1.31, 95% CI 1.23, 1.39, p< 0.001), CKD (HR 1.18, 95% CI 1.14, 1.23, p< 0.001, stroke (HR 1.25, 95% CI 1.17, 1.33, p< 0.001), IHD (HR 1.17, 95% CI 1.11, 1.23, p< 0.001), anemia (HR 1.42, 95% CI 1.14, 1.78, p< 0.01), cancer (HR 1.17, 95% CI 1.04, 1.32, p= 0.01), atrial fibrillation (HR 1.25, 95% CI 1.01, 1.54, p= 0.04), dementia (HR 1.19, 95% CI 1.03, 1.36, p= 0.02) and depression (HR 1.17, 95% CI 1.04, 1.31, p= 0.07).
Conclusions: Comorbid conditions have significantly negative pooled effects on HF patient health outcomes, especially in regard to the prognostic health outcomes. Clinicians should carefully identify and manage these conditions when implementing HF interventions to improve prognostic outcomes.
Relational practice in health, education, criminal justice and social care: A Scoping Review
Authors: Lamph Gary , Nowland Rebecca , Boland Paul , Pearson Jayn , Connell Catriona , Jones Vanessa , Wildbore Ellie , Christian Danielle , Harris Catherine , Ramsden Joanne , Gardner Kathryn , Graham-Kevan Nicola , McKeown Mick 
Published: May 2023

AbstractBackground Establishing and maintaining relationships and ways of connecting and being with others is an important component of health and wellbeing. Harnessing the relational within caring, supportive, educational or carceral settings as a systems response has been referred to as relational practice. Practitioners, people with lived experience, academics and policy makers do not yet share a well-defined common understanding of relational practice. Consequently, there is potential for interdisciplinary and interagency miscommunication, as well as the risk of policy and practice being increasingly disconnected. Comprehensive reviews are needed to support the development of a coherent shared understanding of relational practice. Method This study uses a scoping review design providing a scope and synthesis of extant literature relating relational practice focussing on organisational and systemic practice. The review aimed to map how relational practice is used, defined and understood across health, criminal justice, education and social work, noting any impacts and benefits reported. English language articles were included that involve/discuss practice and/or intervention/s that prioritise interpersonal relationships in service provision, in both external (organisational contexts) and internal (how this is received by workers and service users) aspects. Results A total of 8010 relevant articles were identified, of which 158 met the eligibility criteria and were included in the synthesis. Most were opinion based or theoretical argument papers (n = 61, 38.60%), with 6 (3.80%) critical or narrative reviews. A further 27 (17.09%) were categorised as case studies, focussing on explaining relational practice being used in an organisation or a specific intervention and its components, rather than conducting an evaluation or examination of the effectiveness of the service, with only 11 including any empirical data. Of the included empirical studies, 45 were qualitative, 6 were quantitative and 9 mixed methods studies. There were differences in use of terminology and definitions of relational practice within and across sectors. Conclusion Although there may be implicit knowledge of what relational practice is the research field lacks coherent and comprehensive models. Despite definitional ambiguities a number of benefits are attributed to relational practices. Systematic review registration: The review protocol was registered with PROSPERO (Registration number: PROSPERO 2021 CRD42021295958) and is available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021295958.
Attenuation characteristics of seismic waves beneath North-West Himalaya and North-East India region
Authors: Kumar Vikas , Kumar Dinesh , Chopra Sumer 
Published: May 2023

Abstract
The attenuation characteristics of NW Himalaya and NE India region has been estimated using recorded accelerograms. In this analysis frequency dependent attenuation of P-wave, S wave and coda wave was estimated and the scattering & intrinsic attenuation are separated using Wennerberg (1993) method. The frequency dependent relation of scattering attenuation (QS) and intrinsic attenuation (QI) have also been developed for these seismically active regions. The frequency dependent relations for NW Himalaya are Qα = (67 ± 0.22) f (0.96 ± 0.001), Qβ = (68 ± 0.29) f (0.95 ± 0.002), QC = (107 ± 0.10) f (1.06 ± 0.0003), QI = (95 ± 0.06) f (1.01 ± 0.0002) and QS = (306 ± 6.85) f (0.80 ± 0.009) for P-wave, S-wave, coda wave, intrinsic and scattering attenuation respectively. Similarly, for NE India region the frequency dependent relations are Qα = (89 ± 0.22) f (0.85 ± 0.001), Qβ = (92 ± 0.10) f (0.86 ± 0.0004), QC = (141 ± 0.34) f (1.02 ± 0.0009), QI = (120 ± 0.21) f (0.98 ± 0.0004) and QS = (306 ± 0.66) f (0.77 ± 0.0009) for P-wave, S-wave, coda wave, intrinsic and scattering attenuation respectively. The ratio of Qβ and Qα is greater than 1 for entire frequencies range considered in this analysis which indicates that both NW Himalaya and NE India regions are partially saturated with fluids. The estimated values of intrinsic (QI) and scattering (QS) attenuation shows that intrinsic attenuation is dominant in both NW Himalaya as well as NE India region. The important fact is that in both regions’ QC lies in between QI and QS, which agrees with theoretical and experimental measurements. The frequency dependent of Q’s in this study suggests that both regions are highly heterogenous and low value of Q0’s (i.e. Qα, Qβ and QC) for both regions exhibits high degree of seismicity.
A Lexical Network Approach to Second Language Development
Authors: Chen Heng 
Published: May 2023

Abstract
This study investigates lexical development in second language (L2) learning from the perspective of complex dynamic system theory (CDST) using a complex network method. Based on authentic written output texts from L2 Chinese learners of different proficiency levels and language backgrounds, we successfully differentiate between different proficiency levels using a bi-gram lexical network model. Furthermore, we compare the lexical-network-based approach with the traditional lexical-complexity-based approach. The results show that, compared to traditional lexical complexity indices (such as Average Word Length and Hapax Legomena Percentage), the lexical network indices (such as network size, number of edges, network density, and network centrality) offer greater insight into distinguishing L2 proficiencies and approximating the target language. Furthermore, the findings reveal that L2 Chinese lexical networks exhibit the characteristics of complex networks consistently across all proficiency levels. Additionally, lexical aggregation features, encompassing more than just word frequency information, provide comprehensive properties of the interlanguage system, as supported by their information gain values. We argue that studies within the CDST framework should integrate both lexical complexity and lexical network features to gain a comprehensive understanding of L2 lexical development.
Functional and Textural Characteristics of Fish Mince Sausages Prepared Using Microbial Transglutaminase
Authors: GORE SANDEEP B. , BALANGE AMJAD K. , KATARE MILIND B. , MOGALEKAR H. S. , RELEKAR SHAILENDRA S. , BELSARE SACHIN W. 
Published: May 2023

Abstract
The mince of rohu (Labeo rohita) fish was used to develop susages using microbial transglutaminase (MTGase). The functional (gel strength, water holding capacity, folding score), textural, colour characterstics, protein pattern and microstructure of the mince sausages prepared using MTGase (0, 1, 1.5 & 2%) were studied. MTGase positively enhaced the gel strength, water holding capacity, and folding score of the prepared sausages with an increment in concentration of MTGase. MTGase effectively cross-linked proteins in the gel network as revealed in protein patterns, despite presence of sarcoplasmic proteins. Although low, but the gel strength of mince sausages was found to be comparable with surimi and surimi-based gel products. The different concentration of MTGase did not show any significant influence (p > 0.05) on the textural properties of susages such as hardness, cohesiveness, adhesiveness and elasticity. The variation in colour characteristics of cooked mince sausages particularly whiteness arises from the pigments in mince and the colour of MTGase used during formulation of sausages. MTGase added sausage samples had a finer and homogenous protein network with a smaller void when compared with the gel of mince without MTGase in microstructure analysis. Though potential additive for improvement of functional properties of sausages, availability and cost of MTGase limits its use in the development of value-added fish products such as sausages from mince of freshwater fish.
Stressful life events during the perimenopause: longitudinal observations from the Seattle Midlife Women’s Health Study
Authors: Thomas Annette , Mitchell Ellen Sullivan , Pike Kenneth C. , Woods Nancy Fugate 
Published: May 2023

Abstract
Background Midlife is a time of increased responsibilities for women who have multiple roles including taking care of children, caring for elderly parents, managing households, and working outside the home. With little time for themselves, women additionally experience stressful life events. The purpose of this study was to describe the longitudinal patterns of stressful life events of women during midlife including socio-economic factors and demographic characteristics associated with them.Methods Women who were part of the Seattle Midlife Women’s Health Study (SMWHS), a longitudinal study spanning more than 23 years, who had stressful life events measured at baseline and at years 2, 7, and 10 were included in these analyses. The Life Event Scale, a 70-item scale based on a yes/no response and a Likert-based scoring system with 0 (no effect) to 4 (large effect), was used to determine the total and impact scores of midlife women. The LES was adapted to midlife women from the Norbeck Scale for younger, pregnant women. Analytic strategies consisted of a latent-class growth mixture module to examine subgroups of women with similar exposure to stressful life events using socio-economic factors (gross family income, education, race/ethnicity, employment) and demographic variables (age, marital status, being a parent, and menopausal transition stage) to differentiate trajectories over time.Results Women’s experience of total scores for undesirable stressful life events decreased over time; the impact was sustained over time (65% of the women) or sharply decreased (35% of the women). Women’s experience of total scores for desirable stressful life events were mostly medium high sustainers (61%) compared to high sustainers (27.3%). The impact of desirable stressful life events mostly decreased over time (92.5%). Menopausal transition stages were not significant predictors of stressful life events.Conclusion Midlife women experience stressful life events throughout the menopausal transition. Since the stages were not significant predictors of the ratings of SLEs, a more complex reason, more than biological and including social, may explain the ratings of the women over the course of this ten-year observational study.