bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of dietary live or heat‐killed Bacillus subtilis in goldfish (Carassius auratus) infected with Ichthyophthirius multifiliis
Authors: Shahbazi Parisa , Sheikhzadeh Najmeh , Siahtan Mohamad Ali Nazarpour , Ghadimi Amin Keshavarz , Soltani Mehdi , Nofouzi Katayoon , Mousavi Shalaleh , Khordadmehr Monireh , Marandi Amin , Firouzamandi Masoumeh 
Published: July 2023

AbstractBackgroundThe beneficial effects of Bacillus subtilis on growth, immune response, and disease resistance against various diseases in different fish species have been proved. However, there are no data concerning this probiotic effect on skin mucosal immunity in fish infected with Ichthyophthirius multifiliis (Ich). Ich has a high mortality rate in both edible and ornamental fish and consequently is concerned with heavy economic losses.ObjectivesThus, we assessed the efficacy of live and heat‐killed B. subtilis on skin immunity and histopathology in goldfish (Carassius auratus) infected with Ich.MethodsGoldfish (144 fish, 2.38 g average weight) were stocked in nine glass tanks each in three replicates. Fish were fed 109 CFU g−1 live or heat‐killed B. subtilis for 80 days.ResultsProbiotic administration in both viable and non‐viable forms could enhance the growth performance in goldfish. Probiotic therapy also reduced the density of the parasite and histopathological level on skin and gill tissues of the treated fish. Real‐time polymerase chain reaction analysis showed a higher expression of lysozyme and tumour necrosis factor‐α in the treated groups compared to the control group.ConclusionsThese data demonstrated the beneficial effect of B. subtilis as probiotic and paraprobiotic on growth performance and disease resistance to Ich infestation in goldfish.
Demonstration of hyperfibrinolysis on the VCM Vet in a dog with Angiostrongylus vasorum
Authors: Beeston Dave , Cortellini Stefano 
Published: July 2023

AbstractThis case report details the clinical investigation of an 11‐month‐old, entire, male Cockapoo, who presented with acute left forebrain signs associated with suspected intra‐cranial haemorrhage due to Angiostrongylus vasorum. Initial investigations failed to identify a coagulopathy using traditional coagulation testing. Subsequent viscoelastic testing using the Viscoelastic Coagulation Monitor (VCM Vet, Entegrion) identified a hypocoagulable, hyperfibrinolytic trace. Anti‐fibrinolytic treatment with tranexamic acid showed improvement of hypocoagulability and normalisation of hyperfibrinolysis. Subsequent canine fresh frozen plasma transfusion and treatment of the underlying A. vasorum led to resolution of the patient's coagulopathy. This case report demonstrates the ease of use and utility of viscoelastic monitoring in global assessment of coagulation, and is the first case to document hyperfibrinolysis using the VCM Vet in a patient with Angiostrongylus vasorum.
Successful clinical remission of feline cutaneous lymphangiosarcoma with surgical resection
Authors: McInnis Marley , White Amelia G. , Matz Brad , Yin Ji‐Hang , Lea Christopher 
Published: July 2023

AbstractThis case report highlights the successful management of cutaneous lymphangiosarcoma in an 11‐year‐old, female spayed, domestic longhair cat with surgical resection alone. A 2.0 cm × 1.5 cm, compressible, erythematous, alopecic dermal plaque located on the caudoventral abdomen with associated subcutaneous thickening was cytologically examined, revealing abundant small lymphocytes and a low number of large mesenchymal cells. A definitive diagnosis could not be made based on cytology; therefore, biopsy with histopathology was performed and was consistent with cutaneous lymphangiosarcoma. Complete clinical remission was achieved with curative intent surgical excision. This rare malignant neoplasm of the lymphatic endothelium carries a poor prognosis with rapid progression of disease even after surgical resection. Early diagnosis and aggressive surgical intervention likely resulted in the good outcome in this case.
Unfinished business in a nonlinear sigma model on de Sitter background
Authors: Woodard R. P. , Yesilyurt B. 
Published: July 2023

AbstractNonlinear sigma models on de Sitter background possess the same kind of derivative interactions as gravity, and show the same sorts of large spacetime logarithms in correlation functions and solutions to the effective field equations. It was recently demonstrated that these logarithms can be resummed by combining a variant of Starobinsky’s stochastic formalism with a variant of the renormalization group. This work considers one of these models and completes two pieces of analysis which were left unfinished: the evolution of the background at two loop order and the one loop beta function.
Carroll/fracton particles and their correspondence
Authors: Figueroa-O’Farrill José , Pérez Alfredo , Prohazka Stefan 
Published: July 2023

Abstract
We exploit the close relationship between the Carroll and fracton/dipole algebras, together with the method of coadjoint orbits, to define and classify classical Carroll and fracton particles. This approach establishes a Carroll/fracton correspondence and provides an answer to the question “What is a fracton?”.Under this correspondence, carrollian energy and center-of-mass correspond to the fracton electric charge and dipole moment, respectively. Then immobile massive Carroll particles correspond to the fracton monopoles, whereas certain mobile Carroll particles (“centrons”) correspond to fracton elementary dipoles. We uncover various new massless carrollian/neutral fractonic particles, provide an action in each case and relate them via a GL(2, ℝ) symmetry.We also comment on the limit from Poincaré particles, the relation to (electric and magnetic) Carroll field theories, contrast Carroll boosts with dipole transformations and highlight a generalisation to curved space ((A)dS Carroll).
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj−/− mice
Authors: El-Darzi Nicole , Mast Natalia , Li Yong , Dailey Brian , Kang Min , Rhee Douglas J. , Pikuleva Irina A. 
Published: July 2023

AbstractApolipoprotein J (APOJ) is a multifunctional protein with genetic evidence suggesting an association between APOJ polymorphisms and Alzheimer’s disease as well as exfoliation glaucoma. Herein we conducted ocular characterizations of Apoj−/− mice and found that their retinal cholesterol levels were decreased and that this genotype had several risk factors for glaucoma: increased intraocular pressure and cup-to-disk ratio and impaired retinal ganglion cell (RGC) function. The latter was not due to RGC degeneration or activation of retinal Muller cells and microglia/macrophages. There was also a decrease in retinal levels of 24-hydroxycholesterol, a suggested neuroprotectant under glaucomatous conditions and a positive allosteric modulator of N-methyl-d-aspartate receptors mediating the light-evoked response of the RGC. Therefore, Apoj−/− mice were treated with low-dose efavirenz, an allosteric activator of CYP46A1 which converts cholesterol into 24-hydroxycholesterol. Efavirenz treatment increased retinal cholesterol and 24-hydroxycholesterol levels, normalized intraocular pressure and cup-to-disk ratio, and rescued in part RGC function. Retinal expression of Abcg1 (a cholesterol efflux transporter), Apoa1 (a constituent of lipoprotein particles), and Scarb1 (a lipoprotein particle receptor) was increased in EVF-treated Apoj−/− mice, indicating increased retinal cholesterol transport on lipoprotein particles. Ocular characterizations of Cyp46a1−/− mice supported the beneficial efavirenz treatment effects via CYP46A1 activation. The data obtained demonstrate an important APOJ role in retinal cholesterol homeostasis and link this apolipoprotein to the glaucoma risk factors and retinal 24-hydroxycholesterol production by CYP46A1. As the CYP46A1 activator efavirenz is an FDA-approved anti-HIV drug, our studies suggest a new therapeutic approach for treatment of glaucomatous conditions.
Curved channels with constant cross sections may support trapped surface waves
Authors: Nazarov Sergei A. , Ruotsalainen Keijo M. 
Published: July 2023

AbstractCurved channels with constant cross sections are constructed which support a trapped surface wave. Since corresponding eigenvalues are embedded in the continuous spectrum of the water wave problem and therefore possess the natural instability, the construction procedure requires “fine-tuning” of several parameters in the (small) curvature of the channel as well as geometrical restrictions on the cross section. In particular, the mirror symmetry of the cross section with respect to the vertical axis disrupts the procedure, but examples of suitable non-symmetric cross sections are provided.
Many regular triangulations and many polytopes
Authors: Padrol Arnau , Philippe Eva , Santos Francisco 
Published: July 2023

AbstractWe show that for fixed $$d>3$$

d
>
3

and n growing to infinity there are at least $$(n!)^{d-2 \pm o(1)}$$

(
n
!
)

d
-
2
±
o
(
1
)

different labeled combinatorial types of d-polytopes with n vertices. This is about the square of the previous best lower bounds. As an intermediate step, we show that certain neighborly polytopes (such as particular realizations of cyclic polytopes) have at least $$(n!)^{ \left\lfloor {(d-1)/2} \right\rfloor \pm o(1)}$$

(
n
!
)

(
d
-
1
)
/
2

±
o

(
1
)

regular triangulations.
Optofluidic force induction as a process analytical technology
Authors: Šimić Marko , Neuper Christian , Hohenester Ulrich , Hill Christian 
Published: July 2023

Abstract
Manufacturers of nanoparticle-based products rely on detailed information about critical process parameters, such as particle size and size distributions, concentration, and material composition, which directly reflect the quality of the final product. These process parameters are often obtained using offline characterization techniques that cannot provide the temporal resolution to detect dynamic changes in particle ensembles during a production process. To overcome this deficiency, we have recently introduced Optofluidic Force Induction (of2i) for optical real-time counting with single particle sensitivity and high throughput. In this paper, we apply of2i to highly polydisperse and multi modal particle systems, where we also monitor evolutionary processes over large time scales. For oil-in-water emulsions we detect in real time the transition between high-pressure homogenization states. For silicon carbide nanoparticles, we exploit the dynamic of2i measurement capabilities to introduce a novel process feedback parameter based on the dissociation of particle agglomerates. Our results demonstrate that of2i provides a versatile workbench for process feedback in a wide range of applications.

Graphical abstract
Vacuum and convection drying effects on volatile compounds profile and physicochemical properties of selected herbs from Lamiaceae family
Authors: Żbik Klara , Górska-Horczyczak Elżbieta , Onopiuk Anna , Kurek Marcin , Zalewska Magdalena 
Published: July 2023

AbstractDuring drying herbs, the aim is to preserve their bioactive properties and characteristic aroma, which requires choosing a drying method and parameters that minimize degradation. In this study, the effects of convection and vacuum drying methods on peppermint (Mentha piperita L.), sweet basil (Ocimum basilicum L.), and lemon balm (Melissa officinalis L.) were compared. Fresh herb leaves were dried at 35 °C (using both methods) with an airflow of 0.5 m·s−1 for convection (CONV) and with reduced pressure (300 mbar) for the vacuum method (VAC). Physical and chemical properties were measured (color measurement in the L*a*b* system, weight loss, profile of volatile compounds, total phenolic content (TFC), total flavonoid content (TFC), and total antioxidant activity (TAA)). After drying, a reduction in the brightness of the leaf color and the proportion of red color was observed in most replicates (e.g., for peppermint—control sample L* = 43.11, CONV sample L* = 40.21, VAC sample L* = 37.30). Water evaporated by varying degrees depending on the herb species and the drying method as follows:. The TPC of peppermint was 332.44 mg gallic acid equivalent (GAE)/100 g of sample for CONV and 451.38 for VAC; for sweet basil sequentially: 80.59 and 105.63 GAE/100 g; for lemon balm 248.31 and 314.41 GAE/ 100 g. TFC of peppermint was 244.12 mg quercetin/100 g of sample for CONV and 261.92 for VAC; sweet basil sequentially: 76.91 and 83.31 mg quercetin/100 g; lemon balm 186.50 and 203.87 mg quercetin/100 g. The TAA of peppermint was 84.28% for convection drying, 87.49% for vacuum drying, and sweet basil, it was 20.35% and 47.35% sequentially, and for lemon balm, it was 87.67% and 89.69%. The vacuum method was statistically more effective in preserving the polyphenols and flavonoids in the herbs. Different drying methods also affected the volatile compounds recognized in dried herbs using the Electronic Nose.
Chemical analysis of selected meads produced in Poland
Authors: Dobrowolska-Iwanek Justyna , Kwit Mateusz , Fołta Maria , Rusin Marcelina , Galanty Agnieszka , Zagrodzki Paweł 
Published: July 2023

AbstractThe aim of this study was the analysis of 25 commercially available meads obtained from three leading producers in Poland. In the course of the analyses, the concentration of nine organic acids was determined using the capillary isotachophoresis technique, and the total polyphenol content (58–699 mg/L GAE) and the antioxidant activity were expressed as FRAP (234–6422 µmol/L Fe2+) using spectrophotometric methods. We were able to indicate the acids whose main source was honey—gluconic acid (561–2287 mg/L) and formic acid (35–176 mg/L), the one that was formed during alcoholic fermentation—succinic acid (280–845 mg/L), and also those originating from the additives in the form of fruit juices, or as a result of acidification—tartaric acid (< LOD–159 mg/L), malic acid (135–1611 mg/L) or citric acid (125–4576 mg/L). Our results provide a further contribution to the general knowledge of the chemical composition of meads, and, in particular, these are the first results of this kind for meads commercially available in Poland. The analysis of principal components showed the correlation structure of the examined parameters and the existence of two clusters containing specific meads.
Low-temperature corn straw-degrading bacterial agent and moisture effects on indigenous microbes
Authors: Zhang Sainan , Han Shengcai , Gao Julin , Yu Xiaofang , Hu Shuping 
Published: July 2023

Abstract

While the in situ return of corn straw can improve soil fertility and farmland ecology, additional bacterial agents are required in low-temperature areas of northern China to accelerate straw degradation. Moisture is an important factor affecting microbial activity; however, owing to a lack of bacterial agents adapted to low-temperature complex soil environments, the effects of soil moisture on the interaction between exogenous bacterial agents and indigenous soil microorganisms remain unclear. To this end, we explored the effect of the compound bacterial agent CFF constructed using Pseudomonas putida and Acinetobacter lwoffii, developed to degrade corn straw in low-temperature soils (15 °C), on indigenous bacterial and fungal communities under dry (10% moisture content), slightly wet (20%), and wet (30%) soil-moisture conditions. The results showed that CFF application significantly affected the α-diversity of bacterial communities and changed both bacterial and fungal community structures, enhancing the correlation between microbial communities and soil-moisture content. CFF application also changed the network structure and the species of key microbial taxa, promoting more linkages among microbial genera. Notably, with an increase in soil moisture, CFF enhanced the rate of corn straw degradation by inducing positive interactions between bacterial and fungal genera and enriching straw degradation-related microbial taxa. Overall, our study demonstrates the alteration of indigenous microbial communities using bacterial agents (CFF) to overcome the limitations of indigenous microorganisms for in situ straw-return agriculture in low-temperature areas.

Key points
• Low-temperature and variable moisture conditions (10–30%) were compared
• Soil microbial network structure and linkages between genera were altered
• CFF improves straw degradation via positive interactions between soil microbes
Clinical efficacy and tolerability of venetoclax plus rituximab in patients with relapsed or refractory chronic lymphocytic leukemia—a real-world analysis of the Polish Adult Leukemia Study Group
Authors: Soboń Anita , Drozd-Sokołowska Joanna , Paszkiewicz-Kozik Ewa , Popławska Lidia , Morawska Marta , Tryc-Szponder Jagoda , Bołkun Łukasz , Rybka Justyna , Pruszczyk Katarzyna , Juda Adrian , Majeranowski Alan , Iskierka-Jażdżewska Elżbieta , Steckiewicz Paweł , Wdowiak Kamil , Budziszewska Bożena , Jamroziak Krzysztof , Hus Iwona , Lech-Marańda Ewa , Puła Bartosz 
Published: July 2023

AbstractThe results of the MURANO trial showed encouraging progression-free survival (PFS) and overall survival (OS) in relapsed/refractory chronic lymphocytic leukemia (RR-CLL) patients treated with venetoclax-rituximab (VEN-R). A retrospective analysis was performed to evaluate the efficacy and safety of VEN-R within the Polish Adult Leukemia Study Group (PALG) centers. The study group included 117 patients with RR-CLL (with early relapse after immunochemotherapy or bearing TP53 aberrations) treated with VEN-R in 2019–2023 outside clinical trials. Patients were treated with a median of 2 (range 1–9) previous lines of therapy. Twenty-two participants were previously treated with BTKi (18.8% out of 117). The median follow-up was 20.3 months (range 0.27–39.1). The overall response rate (ORR) was 95.3% in the group of patients in whom a response to treatment was assessed and 86.3% for all patients. Twenty patients (17.1% out of 117) achieved a complete response (CR), 81 (69.2%) achieved a partial response (PR), and in 5 patients (4.3%), disease progression was noted (assessed as the best response during treatment). The median PFS in the whole cohort was 36.97 (95% CI 24.5, not reached) months, and the median OS was not reached (95% CI 27.03, not reached). Thirty-six patients died during the follow-up, 10 (8.5%; 27.8% of deaths) due to COVID-19 infection. All grade neutropenia (n = 87/117, 74.4%; grade 3 or higher n = 67/117, 57.3%) was the most common treatment adverse event. Forty-five patients (38.5%) remained on treatment, and twenty-two (18.8%) completed 24 months of therapy, while it was discontinued in fifty cases (42.7%). In this real-world setting of early access in very high-risk RR-CLL patients, the VEN-R regimen was associated with shorter median PFS compared with the results of the MURANO trial. This outcome, however, could be attributed to patients’ exposure to SARS-CoV-2 infection and the aggressive course of the disease as very high-risk patients, after multiple lines of prior therapies, were included in the Polish Ministry of Health reimbursement program.
Development of a floating element photoelastic force balance
Authors: McLaughlin Bradley , Lawson John , Ganapathisubramani Bharathram 
Published: July 2023

AbstractWe present a floating element force balance design that uses an optical measurement of the force using photoelastic stress analysis. The force sensing element consists of pins embedded in photoelastic polyurethane pads, which generate an internal stress when the floating element is loaded that is observed via a transmission polariscope. A series of known loads and their corresponding fringe patterns allow a calibration matrix to be derived using a polynomial model solved by least squares regression. Finite element analysis (FEA) simulation is carried out to validate the proposed method. The balance then measured a lift curve of the NACA0015 wing at low speed. A comparison of the photoelastic balance and a commercial, 6-axis strain-gauge load cell showed typical differences of less than 6$$\%$$%. This optical approach enables accurate measurements with inexpensive and simple components inside the sensor. This work demonstrates that a photoelastic balance is a simple, inexpensive, and sensitive force transducer.
Vancouver type B2 periprosthetic femoral fractures: clinical and radiological outcomes from a tertiary care center
Authors: Tornago Stefano , Cavagnaro Luca , Mosconi Lorenzo , Chiarlone Francesco , Zanirato Andrea , Patroniti Nicolò , Formica Matteo 
Published: July 2023

Abstract
Introduction
The purpose of this study was to report mid-term clinical and radiographic results after hip arthroplasty revision in Vancouver type B2 femoral periprosthetic fractures (PPFx). Specifical focus of the paper is as follows: (1) the description of a standardized and reproducible surgical technique, (2) functional outcomes presentation and (3) type and number of complications and implants’ survival rate analysis.

Methods
We retrospectively reviewed all patients treated for hip revision with non-modular tapered fluted titanium stem in patients with Vancouver type B2 femur PPFx at a single institution. At least 18 months’ follow-up period was required. Harris Hip Scores and SF-12 were obtained, and radiographical follow-up was performed. Complications were reported and analyzed.

Results
The authors included 114 patients (114 hips) with a mean follow-up of 62.8 ± 30.6 months. All patients were treated with Wagner SL revision hip stem (Zimmer-Biomet), metal cerclage wires ± trochanteric plate. The mean HHS and SF-12 score at the last follow-up evaluation were respectively 81.3 ± 9.7 and 32.5 ± 7.6. Seventeen (14.9%) complications occurred. We observed five cases of dislocations, two of periprosthetic joint infections and six cases of new PPFx. The stem-related revision rate for any cause at the final FU was 1.7%, due to PJI. No patients underwent stem revision surgery for aseptic loosening. Fracture healed in all the included patients with a union-rate of 100%. The re-operation rate for any cause was 9.6%, with an implant survival rate for overall failure of 96.5%.

Conclusion
The presented standard and reproducible surgical technique obtains optimal clinical and radiological results with limited complication rate at mid-term follow up. Preoperative planning as well as careful intraoperative surgical technique is of a paramount importance.