bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rotational atherectomy of left main stem immediately after transcatheter aortic valve implantation in a patient with symptomatic severe aortic stenosis and an impaired left ventricular systolic function: a case report
Authors: Satti Zahir , Farag Mohamed , Egred Mohaned , Alkhalil Mohammad 
Published: July 2023

Abstract

Background
Severe aortic stenosis (AS) and coronary artery disease (CAD) often coexist since they both share the same risk factors and pathophysiology. Patients with severe AS with prohibitive surgical risk are often treated with transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as a staged or concurrent procedure. Significant calcified CAD and left ventricular (LV) systolic impairment in such patients would add more challenges to the management. A clear consensus on the timing of revascularization of such patients in relation to the TAVI procedure is lacking.

Case summary
Herein, we present an 86-year-old male who presented to a local district hospital with non-ST-segment elevation myocardial infarction (N-STEMI) and decompensated heart failure. His transthoracic echocardiography showed moderate LV systolic impairment with low-flow severe AS. He was initially treated with dual anti-platelet and diuretic therapy and subsequently underwent coronary angiography that revealed severe calcified shelf-like left main stem (LMS) and moderate left anterior descending (LAD) disease. He was successfully treated with TAVI and rotational atherectomy (RA)-assisted PCI to LMS and LAD in the same setting.

Conclusion
There is limited evidence on effective strategies to tackle high-risk angioplasty with concurrent TAVI in patients with impaired LV function. We performed TAVI and RA to LMS and LAD in the same setting using no mechanical circulatory support (MCS). Management strategies should be individualized to highly selected patients taking into account LMS involvement, calcium modulation strategies, haemodynamic instability, or cardiogenic shock and whether MCS is needed.
A distaste for insecurity: job preferences of young people in the transition to adulthood
Authors: Rouvroye Lin , van Dalen Hendrik P , Henkens Kène , Schippers Joop J 
Published: July 2023

Abstract
Given the trend towards labour market flexibility in various European countries, this article examines whether the offered type of employment contract has an impact on young people’s ratings of the attractiveness of a job. It empirically assesses the notion that young people’s preference for secure employment increases as they transition into adulthood. We conducted a factorial survey among a representative sample of 1,025 people aged 18–35 years old in the Netherlands. Participants were asked to evaluate hypothetical job offers. Results show that, compared with a permanent contract, the offer of a temporary contract for 3 years has a small negative effect on young adults’ job ratings, whereas offers of an agency contract or an on-call contract have a large negative effect. In line with our predictions, this preference for job security is stronger for men and women who have left the parental home or who have entered parenthood. For men, we also find that their preference for job security is even stronger if they have entered a romantic relationship. These findings suggest that young adults regard insecure employment undesirable, but that, based on their overrepresentation in non-standard employment, their preferences are often not met.
Cardiac pacing and lead devices management: 25 years of research at EP Europace journal
Authors: Defaye Pascal , Biffi Mauro , El-Chami Mikhael , Boveda Serge , Glikson Michael , Piccini Jonathan , Vitolo Marco 
Published: July 2023

Abstract

Aims
Cardiac pacing represents a key element in the field of electrophysiology and the treatment of conduction diseases. Since the first issue published in 1999, EP Europace has significantly contributed to the development and dissemination of the research in this area.

Methods
In the last 25 years, there has been a continuous improvement of technologies and a great expansion of clinical indications making the field of cardiac pacing a fertile ground for research still today. Pacemaker technology has rapidly evolved, from the first external devices with limited longevity, passing through conventional transvenous pacemakers to leadless devices. Constant innovations in pacemaker size, longevity, pacing mode, algorithms, and remote monitoring highlight that the fascinating and exciting journey of cardiac pacing is not over yet.

Conclusion
The aim of the present review is to provide the current ‘state of the art’ on cardiac pacing highlighting the most important contributions from the Journal in the field.
Defining medical deserts—an international consensus-building exercise
Authors: Brînzac Monica G , Kuhlmann Ellen , Dussault Gilles , Ungureanu Marius I , Cherecheș Răzvan M , Baba Cătălin O 
Published: July 2023

AbstractBackgroundMedical deserts represent a pressing public health and health systems challenge. The COVID-19 pandemic further exacerbated the gap between people and health services, yet a commonly agreed definition of medical deserts was lacking. This study aims to define medical deserts through a consensus-building exercise, explaining the phenomenon to its full extent, in a manner that can apply to countries and health systems across the globe.MethodsWe used a standard Delphi exercise for the consensus-building process. The first phase consisted of one round of individual online meetings with selected key informants; the second phase comprised two rounds of surveys when a consensus was reached in January 2023. The first phase—the in-depth individual meetings—was organized online. The dimensions to include in the definition of medical deserts were identified, ranked and selected based on their recurrence and importance. The second phase—the surveys—was organized online. Finally, external validation was obtained from stakeholders via email.ResultsThe agreed definition highlight five major dimensions: ‘Medical deserts are areas where population healthcare needs are unmet partially or totally due to lack of adequate access or improper quality of healthcare services caused by (i) insufficient human resources in health or (ii) facilities, (iii) long waiting times, (iv) disproportionate high costs of services or (v) other socio-cultural barriers’.ConclusionsThe five dimensions of access to healthcare: (i) insufficient human resources in health or (ii) facilities, (iii) long waiting times, (iv) disproportionate high costs of services and (v) other socio-cultural barriers—ought to be addressed to mitigate medical deserts.
Estimation of the Hurst exponents of irregularly sampled subsurface fault geometries by the lifting scheme
Authors: Takahashi Tsutomu , Nakanishi Ayako , Kodaira Shuichi , Kaneda Yoshiyuki 
Published: July 2023

SUMMARY
Seismic fault surfaces have complex geometries over a broad-scale range. The Hurst exponent (H) is an important parameter characterizing the complexity of fault geometries. This exponent of seismic faults has only been estimated at outcrops and from surface traces of large earthquakes. This is because geometry data of subsurface faults usually have large uncertainties and many gaps. This study examined the applicability of the lifting scheme, which is one of the wavelet transform methods, to estimate H of irregularly sampled geometry of subsurface faults. We analysed the surface geometry of the subducting oceanic plate at the Nankai trough, Japan, which is part of the fault plane of interplate earthquakes. The geometries of the subducting plate were estimated along six survey lines by integrating seismic refraction and reflection surveys. Two-way traveltimes of reflected waves from the plate surface, which were measured from the reflection survey data, were converted to depth using the velocity structure estimated by refraction survey. The intervals between sampled points were irregular because the reflected waves were obscured or invisible in some places. The Hurst exponents were estimated from the scale dependence of the wavelet coefficients that were derived by the lifting scheme without interpolation. Analyses of the synthetic data simulating the irregularly sampled plate geometries indicated that the lifting scheme yields stable but largely biased estimates of H, especially for small H (&lt;0.5). We introduced the empirical bias correction to achieve an unbiased estimation of the exponent. The analysis of plate geometry at the Nankai trough was conducted at narrow-scale ranges with consideration for the accuracy of velocity structures. We may conclude that H of five survey lines across the trough axis is &gt; 0.8, and that of a line along trough is &gt; 0.7. These estimated exponents had large uncertainties due to analyses at narrow-scale ranges, but were close to the estimates in studies of the surface traces of large earthquakes.
Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods
Authors: Ajayi Oluwaseun M , Wynne Nicole E , Chen Shyh-Chi , Vinauger Clément , Benoit Joshua B 
Published: July 2023

Synopsis
Understanding the biology of blood-feeding arthropods is critical to managing them as vectors of etiological agents. Circadian rhythms act in the regulation of behavioral and physiological aspects such as blood feeding, immunity, and reproduction. However, the impact of sleep on these processes has been largely ignored in blood-feeding arthropods, but recent studies in mosquitoes show that sleep-like states directly impact host landing and blood feeding. Our focus in this review is on discussing the relationship between sleep and circadian rhythms in blood-feeding arthropods along with how unique aspects such as blood gluttony and dormancy can impact sleep-like states. We highlight that sleep-like states are likely to have profound impacts on vector–host interactions but will vary between lineages even though few direct studies have been conducted. A myriad of factors, such as artificial light, could directly impact the time and levels of sleep in blood-feeding arthropods and their roles as vectors. Lastly, we discuss underlying factors that make sleep studies in blood-feeding arthropods difficult and how these can be bypassed. As sleep is a critical factor in the fitness of animal systems, a lack of focus on sleep in blood-feeding arthropods represents a significant oversight in understanding their behavior and its role in pathogen transmission.
Concomitant left atrial appendage closure during left ventricular assist device surgery can reduce ischaemic cerebrovascular accidents
Authors: Nishida Hidefumi , Jeevanandam Valluvan , Salerno Christopher , Nemoto Atsushi , Song Tae , Onsager David , Nguyen Ann , Grinstein Jonathan , Chung Bow , Sarswat Nitasha , Kim Gene , Pinney Sean , Ota Takeyoshi 
Published: July 2023

Abstract

OBJECTIVES
It remains unknown if the left atrial appendage closure (LAAC) at the time of left ventricular assist device (LVAD) surgery can reduce ischaemic cerebrovascular accidents.

METHODS
Consecutive 310 patients who underwent LVAD surgery with HeartMate II or 3 between January 2012 and November 2021 were included in this study. The cohort was divided into 2 groups: patients with LAAC (group A) and without LAAC (group B). We compared the clinical outcomes including the incidence of cerebrovascular accident between 2 groups.

RESULTS
Ninety-eight patients were included in group A, and 212 patients in group B. There were no significant differences between 2 groups in age, preoperative CHADS2 score and history of atrial fibrillation. In-hospital mortality did not differ significantly between the 2 groups (group A: 7.1%, group B: 12.3%, P = 0.16). Thirty-seven patients (11.9%) experienced ischaemic cerebrovascular accident (5 patients in group A and 32 patients in group B). The cumulative incidence from ischaemic cerebrovascular accidents in group A (5.3% at 12 months and 5.3% at 36 months) was significantly lower than that in group B (8.2% at 12 months and 16.8% at 36 months; P = 0.017). In a multivariable competing risk analysis, LAAC was associated with reducing ischaemic cerebrovascular accidents (hazard ratio 0.38, 95% confidence interval 0.15–0.97, P = 0.043).

CONCLUSIONS
Concomitant LAAC in LVAD surgery can reduce ischaemic cerebrovascular accidents without increasing perioperative mortality and complications.
Pilot testing of the International Council of Cardiovascular Prevention and Rehabilitation Registry
Authors: Grace Sherry L , Elashie Sana , Sadeghi Masoumeh , Papasavvas Theodoros , Hashmi Farzana , de Melo Ghisi Gabriela , Vargas Jorge Lara , Al-Hashemi Mohammed , Turk-Adawi Karam 
Published: July 2023

Abstract
The International Council of Cardiovascular Prevention and Rehabilitation developed an International Cardiac Rehabilitation (CR) Registry (ICRR) to support CR programs in low-resource settings to optimize care provision and patient outcomes. This study assessed implementation of the ICRR, site data steward experience with on-boarding and data entry, and patient acceptability. Multimethod observational pilot involves (I) analysis of ICRR data from three centers (Iran, Pakistan, and Qatar) from inception to May 2022, (II) focus group with on-boarded site data stewards (also from Mexico and India), and (III) semistructured interviews with participating patients. Five hundred sixty-seven patients were entered. Based on volumes at each program, 85.6% of patients were entered in ICRR. 99.3% patients approached consented to participate. The average time to enter data at pre- and follow-up assessments by source was 6.8–12.6 min. Of 22 variables preprogram, completion was 89.5%. Among patients with any follow-up data, of four program-reported variables, completion was 99.0% in program completers and 51.5% in none; of 10 patient-reported variables, completion was 97.0% in program completers and 84.8% in none. The proportion of patients with any follow-up data was 84.8% in program completers, with 43.6% of noncompleters having any data entered other than completion status. Twelve data stewards participated in the focus group. Main themes were valuable on-boarding process, data entry, process of engaging patients, and benefits of participation. Thirteen patients were interviewed. Themes were good understanding of the registry, positive experience providing data, and value of lay summary and eagerness for annual assessment. Feasibility and data quality of ICRR were demonstrated.
Phylogenomics of microleafhoppers (Hemiptera: Cicadellidae: Typhlocybinae): morphological evolution, divergence times, and biogeography
Authors: Cao Yanghui , Dietrich Christopher H , Kits Joel H , Dmitriev Dmitry A , Richter Robin , Eyres Jackson , Dettman Jeremy R , Xu Ye , Huang Min 
Published: July 2023

Abstract
Phylogenomic analyses of datasets comprising 665 anchored loci and 234 species representing all recognized tribes and regional faunas of the leafhopper subfamily Typhlocybinae yielded well-resolved phylogenies for this group, largely robust to differences in analytical approach. The results support the 5 currently recognized tribes as monophyletic: Alebrini, Empoascini, Typhlocybini, Dikraneurini, and Erythroneurini, but the previously recognized tribes Zyginellini and Eupterygini are polyphyletic. A new tribe Beameranini is described based on the morphologically aberrant Neotropical genus Beamerana Young. Morphological characters traditionally used to recognize tribes are mostly stable but nearly all exhibit some homoplasy, with similar reductions and consolidations of some hind wing veins having occurred in independent lineages. Divergence time estimates indicate that the currently recognized tribes all arose during the mid- to late Cretaceous with some early splits between New and Old World lineages occur during the late Cretaceous, but most modern genera arising during the Paleogene and multiple transcontinental dispersal events also occur in the Paleogene.
Women’s perspectives on the use of artificial intelligence (AI)-based technologies in mental healthcare
Authors: Reading Turchioe Meghan , Harkins Sarah , Desai Pooja , Kumar Shiveen , Kim Jessica , Hermann Alison , Joly Rochelle , Zhang Yiye , Pathak Jyotishman , Benda Natalie C 
Published: July 2023

AbstractThis study aimed to evaluate women’s attitudes towards artificial intelligence (AI)-based technologies used in mental health care. We conducted a cross-sectional, online survey of U.S. adults reporting female sex at birth focused on bioethical considerations for AI-based technologies in mental healthcare, stratifying by previous pregnancy. Survey respondents (n = 258) were open to AI-based technologies in mental healthcare but concerned about medical harm and inappropriate data sharing. They held clinicians, developers, healthcare systems, and the government responsible for harm. Most reported it was “very important” for them to understand AI output. More previously pregnant respondents reported being told AI played a small role in mental healthcare was “very important” versus those not previously pregnant (P = .03). We conclude that protections against harm, transparency around data use, preservation of the patient-clinician relationship, and patient comprehension of AI predictions may facilitate trust in AI-based technologies for mental healthcare among women.
Characterization of K-binding factor involved in water-soluble complex of menaquinone-7 produced by Bacillus subtilis natto
Authors: Chatake Toshiyuki , Yanagisawa Yasuhide , Murakami Risa , Ohsugi Tadanori , Sumi Hiroyuki , Takata Takumi , Okuda Aya , Morishima Ken , Inoue Rintaro , Sugiyama Masaaki 
Published: July 2023

Abstract
Vitamin Ks are expected to contribute bone and cardiovascular health. Especially, menaquinone-7 has a higher bioavailability and a longer half-life than other vitamin Ks in the human body. However, their low water-solubility limits their application. On the other hand, Bacillus subtilis natto produces a water-soluble complex, which comprises menaquinone-7 and peptides. The peptide named K-binding factor (KBF) has been reported as the main component of the complex. In the present, the structural characteristics of KBF were studied. Mass spectrometry showed significant peaks at m/z = 1050, while the previous PAGE suggested that molecular weight of KBF was ~ 3k. Amino acid analysis revealed that the 1k peptides were the various combinations of nine amino acids, among which Asx, Glx, Val, Leu and Met were found to be the most abundant. The peptides could serve as detergent properties. The 1k peptides could be isolated by reverse-phase high performance liquid chromatography. The bundle of three 1k detergent-like peptides would participate to the micelle structure containing menqauinone-7 inside. In conclusion, a basic unit of KBF would be the ~ 1k peptides, and the three basic unit assemble to the ~ 3k bundle, then the bundle form a water-soluble micelle including menqauinone-7 inside.
Perineal fibroadenoma masquerading as a soft-tissue sarcoma: a case report
Authors: Hannigan Amy , Wende Gabriella , Cohen Ryan , Chetrit Stephanie 
Published: July 2023

Abstract
We report a case of a perineal fibroadenoma initially diagnosed on ultrasound and magnetic resonance imaging as a soft tissue sarcoma in a 35-year-old female. Following wide local excision, histopathology revealed the lesion as a vulval fibroadenoma. We provide an overview of the literature and highlight the need to consider fibroadenoma, arising from ectopic breast tissue, as an important differential for general surgeons and gynaecologists caring for patients with perineal masses.
Assessment of revascularization impact on microvascular oxygenation and perfusion using spatial frequency domain imaging
Authors: Bolakale-Rufai Ikeoluwapo K , Thompson Mallory R , Concha-Moore Kirsten , Jett Samuel , Awasthi Shubhangi , Cuccia David J , Mazhar Amaan , Weinkauf Craig C 
Published: July 2023

Abstract
The microvasculature (with vessels &lt;100 μm in diameter) plays a crucial role in tissue oxygenation, perfusion and wound healing in the lower limb. While this holds clinical significance, microvasculature evaluation in the limbs is not a standard practice. Surgical interventions focus on reestablishing blood flow in larger vessels affected by the peripheral artery disease (PAD). Nevertheless, the impact of revascularization on tissue oxygenation and perfusion in severe microvascular disease (MVD) is still unknown. We present the cases of two patients who underwent surgical revascularization for peripheral blood flow with different outcomes. Patient A had PAD, while B had PAD, severe MVD and a non-healing wound. Although both showed improvements in ankle-brachial index post-op, spatial frequency domain imaging metrics (which measure microvascular oxygenation and perfusion) remained unchanged in B, indicating a potential gap in assessing the surgical efficacy in MVD using ankle brachial index and emphasizing microcirculation evaluation in optimizing wound healing outcomes.
Renewable hydrogen and power-to-gas—regulatory framework and developments in light of the REPowerEU plan
Authors: Cellura Salvatore Luca , Ferraro Marco 
Published: July 2023

Abstract
Renewable hydrogen represents a promising technology, especially to meet climate goals and decarbonize several key sectors of the productive system. The number of possible applications is considerable, as it is its potential contribution to the climate goals. This technology is, however, still at an early stage, and so is the European Union (EU) legal framework that should uphold its development. This article tries to give an outlook on some key points of the applicable EU policy on hydrogen (especially renewable and low-carbon), as well as examine some specific Union legal frameworks that are applicable, and the critical issues that the current regime, still in its early stages, inevitably presents. The article also highlights the recent EU policy developments that, due to the actual geopolitical situation, are seemingly boosting up the European agenda on hydrogen.
Strange quasar candidates with abnormal astrometric characteristics from Gaia EDR3 and SDSS (SQUAB-II): optical identifications
Authors: Ji Xiang , Zheng Zhen-Ya , Wu Qiqi , Lin Ruqiu , Rahna P T , Zhang Yingkang , Zhu Shuairu , Liao Shilong , Qi Zhaoxiang , An Tao 
Published: July 2023

ABSTRACT
There are some strange quasars with multiple Gaia detections or observed with abnormal astrometric characteristics, such as with large proper motions or significant astrometric noises. Those strange quasars could be potential candidates of quasar-star pairs, dual quasars (DQs), or lensed quasars (LQs). Searching for both DQs and LQs is of great importance in many fields of astrophysics. Here in this work, we select 143 SDSS spectroscopically confirmed quasars that have multiple Gaia EDR3 detections within 1 arcsec of the SDSS quasar’s position. We apply several optical identification methods to classify this sample. We firstly exclude 65 quasar-star pairs via their stellar features including their parallaxes and proper motions, stellar features in the SDSS spectra, or via the colour–colour diagram. Based on the spectral-fitting results, we find 2 DQ candidates, one of which presents a double-peaked [O III] emission line feature and the other shows a broad Hβ velocity offset (∼ 870 km s−1) relative to the [O III] λ5007 line. Via the colour difference method, we further find 56 LQ candidates with similar colours in their multiple images. We also cross-match 143 objects with the HST archive and find 19 targets with archival HST images. Our classification results of those 19 targets are mainly consistent with previous works.