bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture-related techniques for postoperative cognitive complications: a systemic review and meta-analysis
Authors: Zhang Junbao , Cairen Zhuoma , Shi Liwen , Zhang Minjuan , Yang Manping , Wang Yun , Lu Zhihong 
Published: May 2023

Abstract
Background
Postoperative cognitive complications are major challenges for postoperative recovery. Acupuncture-related techniques have been used for treating neurocognitive dysfunctions. However, whether they help to prevent postoperative cognitive complicationss remains unclear. We intend to evaluate the effect of acupuncture-related techniques on the incidence of postoperative cognitive complications (PCC) in patients undergoing surgery under general anesthesia.

Methods
Based on PRISMA guidelines, a search of PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov was performed to identify eligible trials published from inception to June 6, 2021. The search was performed in June 2021. The inclusion criteria were prospective, randomized, controlled clinical trials that compared acupuncture-related techniques with other techniques or non-acupuncture treatment in patients undergoing surgery under general anesthesia. Pooled odds ratios (ORs), 95% CIs, and P values were estimated for end points using fixed and random effects statistical models.

Results
The analysis included 12 studies with 1058 patients. Compared with patients not receiving acupuncture, patients treated with acupuncture-related techniques had a lower incidence of PCCs (OR, 0.44; 95% CI, 0.33 to 0.59; P < 0.001; n = 968) and lower levels of biomarkers, including IL-6, TNF-α, and S100β. Acupuncture with needles and without needles showed similar effects on the prevention of PCCs. The effects of acupuncture-related techniques on PCCs were observed in both English and non-English articles. Subgroup analyses showed that both agitation and/or delirium (OR, 0.51; 95% CI, 0.34 to 0.76; P < 0.001; n = 490) and delayed cognitive recovery (OR, 0.33; 95% CI, 0.21 to 0.51; P < 0.001; n = 478) were reduced after treatment with acupuncture-related techniques. In adult studies evaluating MMSE scores, the scores were not different between groups (SMD, − 0.71; 95% CI, − 1.72 to 0.3; P = 0.17; n = 441).

Conclusions
Acupuncture-related techniques, including needle techniques and electrical techniques, are associated with fewer postoperative cognitive complications, suggesting that acupuncture could be considered a potential option in the perioperative setting. Additional research is needed to develop higher-quality evidence and optimal regimens.

Trial registration
PROSPERO (CRD42021258378).
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis
Authors: Shao Dan , Shen Wenxiang , Miao Yuyang , Gao Zhen , Pan Menghao , Wei Qiang , Yan Zuoting , Zhao Xiaoe , Ma Baohua 
Published: May 2023

Abstract
Background
Mastitis not only deteriorates the composition or quality of milk, but also damages the health and productivity of dairy goats. Sulforaphane (SFN) is a phytochemical isothiocyanate compound with various pharmacological effects such as anti-oxidant and anti-inflammatory. However, the effect of SFN on mastitis has yet to be elucidated. This study aimed to explore the anti-oxidant and anti-inflammatory effects and potential molecular mechanisms of SFN in lipopolysaccharide (LPS)-induced primary goat mammary epithelial cells (GMECs) and a mouse model of mastitis.

Results
In vitro, SFN downregulated the mRNA expression of inflammatory factors (tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6), inhibited the protein expression of inflammatory mediators (cyclooxygenase-2 (COX2), and inducible nitric oxide synthase (iNOS)) while suppressing nuclear factor kappa-B (NF-κB) activation in LPS-induced GMECs. Additionally, SFN exhibited an antioxidant effect by increasing Nrf2 expression and nuclear translocation, up-regulating antioxidant enzymes expression, and decreasing LPS-induced reactive oxygen species (ROS) production in GMECs. Furthermore, SFN pretreatment promoted the autophagy pathway, which was dependent on the increased Nrf2 level, and contributed significantly to the improved LPS-induced oxidative stress and inflammatory response. In vivo, SFN effectively alleviated histopathological lesions, suppressed the expression of inflammatory factors, enhanced immunohistochemistry staining of Nrf2, and amplified of LC3 puncta LPS-induced mastitis in mice. Mechanically, the in vitro and in vivo study showed that the anti-inflammatory and anti-oxidative stress effects of SFN were mediated by the Nrf2-mediated autophagy pathway in GMECs and a mouse model of mastitis.

Conclusions
These results indicate that the natural compound SFN has a preventive effect on LPS-induced inflammation through by regulating the Nrf2-mediated autophagy pathway in primary goat mammary epithelial cells and a mouse model of mastitis, which may improve prevention strategies for mastitis in dairy goats.
An open-source platform for sub-$$\textrm{g}$$, sub-$$\upmu$$A data loggers
Authors: Brown Geoffrey M. , Chen Jiawei , Fudickar Adam , Jahn Alex E. 
Published: May 2023

Abstract
Background
Rapid improvements in inexpensive, low-power, movement and environmental sensors have sparked a revolution in animal behavior research by enabling the creation of data loggers (henceforth, tags) that can capture fine-grained behavioral data over many months. Nevertheless, development of tags that are suitable for use with small species, for example, birds under 25 g, remains challenging because of the extreme mass (under 1$$\textrm{g}$$
g
) and power (average current under 1$$\upmu$$
μ
A) constraints. These constraints dictate that a tag should carry exactly the sensors required for a given experiment and the data collection protocol should be specialized to the experiment. Furthermore, it can be extremely challenging to design hardware and software to achieve the energy efficiency required for long tag life.

Results
We present an activity monitor, BitTag, that can continuously collect activity data for 4–12 months at 0.5–0.8$$\textrm{g}$$
g
, depending upon battery choice, and which has been used to collect more than 500,000 h of data in a variety of experiments. The BitTag architecture provides a general platform to support the development and deployment of custom sub-$$\textrm{g}$$
g
tags. This platform consists of a flexible tag architecture, software for both tags and host computers, and hardware to provide the host/tag interface necessary for preparing tags for “flight” and for accessing tag data “post-flight”. We demonstrate how the BitTag platform can be extended to quickly develop novel tags with other sensors while satisfying the 1g/1$$\upmu$$
μ
A mass and power requirements through the design of a novel barometric pressure sensing tag that can collect pressure and temperature data every 60$$\textrm{s}$$
s
for a year with mass under 0.6$$\textrm{g}$$
g
.
Does workplace telepressure get under the skin? Protocol for an ambulatory assessment study on wellbeing and health-related physiological, experiential, and behavioral concomitants of workplace telepressure
Authors: Semaan Raphaël , Nater Urs M. , Heinzer Raphaël , Haba-Rubio José , Vlerick Peter , Cambier Ruben , Gomez Patrick 
Published: May 2023

AbstractBackgroundThe daily working life of many employees requires the use of modern information and communication technology (ICT) devices such as computers, tablets, and smartphones. The double-edged nature of digital work environments has been increasingly highlighted. Benefits such as increased flexibility come at a personal cost. One of the potential downsides is workplace telepressure, i.e., the experience of urge and preoccupation to quickly reply to work-related messages and demands using ICT. There is initial − mainly survey-based−evidence that workplace telepressure may have negative effects on a variety of wellbeing and health outcomes.Aims and hypothesesAdopting the Effort-Recovery Model and the concept of allostatic load as theoretical frameworks, the present study aims to investigate the hypothesis that workplace telepressure is significantly associated with increased “wear and tear”, in the form of more psychosomatic complaints, worse sleep quality (self-reported and actigraphy-based), worse mood, and biological alterations (lower cardiac vagal tone, lower anabolic balance defined as the ratio of salivary dehydroepiandrosterone to salivary cortisol, and higher salivary alpha-amylase). Additionally, the study aims to investigate the hypothesis that connection to work defined as work-related workload and work-related perseverative cognition plays a significant role in the mediation of these relationships.MethodsTo test our hypotheses, we will conduct an ambulatory assessment study with a convenience sample of 120 healthy workers regularly using ICTs for job communication. For one week, participants will be asked to complete electronic diaries assessing their level of workplace telepressure, psychosomatic complaints, sleep quality, mood, work-related workload, and work-related perseverative cognition. They will also continuously wear the Bittium Faros 180L ECG monitor, the wrist-worn actigraph MotionWatch 8, and perform saliva sampling five times per day.DiscussionThis study will be the most comprehensive ambulatory investigation of workplace telepressure and its psychophysiological concomitants to date and constitutes an important step towards understanding how high levels of workplace telepressure may lead in the long term to secondary alterations (e.g., hypertension, chronic inflammation) and disease (e.g., heart disease). The findings of this study are also anticipated to contribute to guiding the development and implementation of interventions, programs, and policies relevant to employees’ digital wellbeing.
How much of my true self can i show? social adaptation in autistic women: a qualitative study
Authors: Sunagawa Mebuki 
Published: May 2023

Abstract
Background
Social adaptation is often aimed at supporting autistic people, yet its specific goals may not include their actual perspectives. That is, the state of adaptation is judged based on the standards and values of non-autistic people. This qualitative study focused on autistic women’s perceptions of social adaptation and examined their lived experiences in daily life, as adaptive behaviors have often been reported as a “female autism phenotype.”

Methods
Semi-structured interviews were conducted face-to-face with ten autistic women aged 28–50 years (M = 36.7; standard SD = 7.66). The analysis was conducted based on the grounded theory approach.

Results
Two core perceptions were identified: maintaining stable relationships and fulfilling social roles based on past experiences of “maladaptation.” The participants sought adaptations within a reasonable range and adjusted their balance with society to maintain stability in their daily lives.

Conclusion
The findings indicated that autistic women’s perceptions of adaptation were based on the accumulation of past negative experiences. Further harmful efforts should be prevented. Support for autistic people to make their own choices in life is also important. Moreover, autistic women need a place where they can be themselves and be accepted as they are. This study showed the importance of changing the environment rather than modifying autistic people to adapt to a society.
The spatial distribution of traditional intangible cultural heritage medicine of China and its influencing factors
Authors: Nie Xin , Ma MingZhao , Ji JiaQing , Zheng LunXing 
Published: May 2023

Abstract
Intangible cultural heritage (ICH) of traditional Chinese medicine is a vivid testimony to the continuous inheritance of Chinese civilization. The study of ICH of traditional Chinese medicine from the perspective of the geographical environment, spatial relationships and diachronic development is of great significance for understanding objectively the reasons for the formation of spatial distribution patterns of ICH and the pathways and extent of its spread; as a consequence, such information can help us improve our understanding of the integrity and historical continuity of culture. From a geography perspective, this study seeks to explore the spatial patterns of traditional Chinese medicine ICH based on knowledge concerning the extent of spreading of traditional Chinese medicine ICH. At the same time, the spatial analysis technique ArcGIS is used to express the spatiotemporal development of traditional Chinese medicine ICH in a simple, clear and visual way. Also, the factors influencing the spatial distribution of traditional Chinese medicine ICH are analyzed. The main findings are as follows: (1) The spatial distribution of traditional Chinese medicine ICH practices is cohesive as a whole, with a tendency to aggregate and strong imbalance in distribution. (2) There are significant differences in the classification and number of traditional Chinese medicine ICH. (3) Traditional Chinese medicine ICH practices have obvious differentiation in time and space distribution when factoring in their announcement in batches. (4) Traditional medicine practices have significant spatial autocorrelation. Appreciation of the aforementioned features allows us to gain consensus on the development and evolution of traditional Chinese medicine ICH, and hence can justify how we allocate funds to promote traditional Chinese medicine ICH projects, paying particular attention to researching the historical context, and preserving the extraction of the local characteristics of traditional Chinese medicine ICH.
Triple modality image reconstruction of PET data using SPECT, PET, CT information increases lesion uptake in images of patients treated with radioembolization with $$^{90}Y$$ micro-spheres
Authors: Deidda Daniel , Denis-Bacelar Ana M. , Fenwick Andrew J. , Ferreira Kelley M. , Heetun Warda , Hutton Brian F. , McGowan Daniel R. , Robinson Andrew P. , Scuffham James , Thielemans Kris , Twyman Robert 
Published: May 2023

Abstract
Purpose
Nuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET) are employed in the field of theranostics to estimate and plan the dose delivered to tumors and the surrounding tissues and to monitor the effect of the therapy. However, therapeutic radionuclides often provide poor images, which translate to inaccurate treatment planning and inadequate monitoring images. Multimodality information can be exploited in the reconstruction to enhance image quality. Triple modality PET/SPECT/CT scanners are particularly useful in this context due to the easier registration process between images. In this study, we propose to include PET, SPECT and CT information in the reconstruction of PET data. The method is applied to Yttrium-90 ($$^{90}$$

90

Y) data.

Methods
Data from a NEMA phantom filled with $$^{90}$$

90

Y were used for validation. PET, SPECT and CT data from 10 patients treated with Selective Internal Radiation Therapy (SIRT) were used. Different combinations of prior images using the Hybrid kernelized expectation maximization were investigated in terms of VOI activity and noise suppression.

Results
Our results show that triple modality PET reconstruction provides significantly higher uptake when compared to the method used as standard in the hospital and OSEM. In particular, using CT-guided SPECT images, as guiding information in the PET reconstruction significantly increases uptake quantification on tumoral lesions.

Conclusion
This work proposes the first triple modality reconstruction method and demonstrates up to 69% lesion uptake increase over standard methods with SIRT $$^{90}$$

90

Y patient data. Promising results are expected for other radionuclide combination used in theranostic applications using PET and SPECT.
Ameliorating the drought stress tolerance of a susceptible soybean cultivar, MAUS 2 through dual inoculation with selected rhizobia and AM fungus
Authors: Ashwin Revanna , Bagyaraj Davis Joseph , Mohan Raju Basavaiah 
Published: May 2023

Abstract
Background
Drought stress is currently the primary abiotic stress factor for crop loss worldwide. Although drought stress reduces the crop yield significantly, species and genotypes differ in their stress response; some tolerate the stress effect while others not. In several systems, it has been shown that, some of the beneficial soil microbes ameliorate the stress effect and thereby, minimizing yield losses under stress conditions. Realizing the importance of beneficial soil microbes, a field experiment was conducted to study the effect of selected microbial inoculants namely, N-fixing bacteria, Bradyrhizobium liaoningense and P-supplying arbuscular mycorrhizal fungus, Ambispora leptoticha on growth and performance of a drought susceptible and high yielding soybean cultivar, MAUS 2 under drought condition.

Results
Drought stress imposed during flowering and pod filling stages showed that, dual inoculation consisting of B. liaoningense and A. leptoticha improved the physiological and biometric characteristics including nutrient uptake and yield under drought conditions. Inoculated plants showed an increased number of pods and pod weight per plant by 19% and 34% respectively, while the number of seeds and seed weight per plant increased by 17% and 32% respectively over un-inoculated plants under drought stress condition. Further, the inoculated plants showed higher chlorophyll and osmolyte content, higher detoxifying enzyme activity, and higher cell viability because of less membrane damage compared to un-inoculated plants under stress condition. In addition, they also showed higher water use efficiency coupled with more nutrients accumulation besides exhibiting higher load of beneficial microbes.

Conclusion
Dual inoculation of soybean plants with beneficial microbes would alleviate the drought stress effects, thereby allowing normal plants’ growth under stress condition. The study therefore, infers that AM fungal and rhizobia inoculation seems to be necessary when soybean is to be cultivated under drought or water limiting conditions.
Protocol for a randomised pilot study of a novel Parent–Child Interaction Therapy (PCIT) ‘re-implementation’ intervention
Authors: Woodfield Melanie J. , Cargo Tania , Merry Sally , Hetrick Sarah E. 
Published: May 2023

Abstract
Background
Despite a number of clinicians having been trained in Parent–Child Interaction Therapy (PCIT) in Aotearoa/New Zealand, few are regularly delivering the treatment, with barriers to use including a lack of suitable equipment and lack of professional support. This pragmatic, parallel-arm, randomised, controlled pilot trial includes PCIT-trained clinicians who are not delivering, or only rarely utilising, this effective treatment. The study aims to assess the feasibility, acceptability and cultural responsivity of study methods and intervention components and to collect variance data on the proposed future primary outcome variable, in preparation for a future, larger trial.

Methods
The trial will compare a novel ‘re-implementation’ intervention with a refresher training and problem-solving control. Intervention components have been systematically developed to address barriers and facilitators to clinician use of PCIT using implementation theory, and a draft logic model with hypothesised mechanisms of action, derived from a series of preliminary studies. The intervention includes complimentary access to necessary equipment for PCIT implementation (audio-visual equipment, a ‘pop-up’ time-out space, toys), a mobile senior PCIT co-worker and an optional weekly PCIT consultation group, for a 6-month period. Outcomes will include the feasibility of recruitment and trial procedures; acceptability of the intervention package and data collection methods to clinicians; and clinician adoption of PCIT.

Discussion
Relatively little research attention has been directed at interventions to resurrect stalled implementation efforts. Results from this pragmatic pilot RCT will refine and shape knowledge relating to what it might take to embed the ongoing delivery of PCIT in community settings, providing more children and families with access to this effective treatment.

Trial registration
ANZCTR, ACTRN12622001022752, registered on July 21, 2022.
Tail spillover effects between cryptocurrencies and uncertainty in the gold, oil, and stock markets
Authors: Mensi Walid , Gubareva Mariya , Ko Hee-Un , Vo Xuan Vinh , Kang Sang Hoon 
Published: May 2023

AbstractThis study investigates tail dependence among five major cryptocurrencies, namely Bitcoin, Ethereum, Litecoin, Ripple, and Bitcoin Cash, and uncertainties in the gold, oil, and equity markets. Using the cross-quantilogram method and quantile connectedness approach, we identify cross-quantile interdependence between the analyzed variables. Our results show that the spillover between cryptocurrencies and volatility indices for the major traditional markets varies substantially across quantiles, implying that diversification benefits for these assets may differ widely across normal and extreme market conditions. Under normal market conditions, the total connectedness index is moderate and falls below the elevated values observed under bearish and bullish market conditions. Moreover, we show that under all market conditions, cryptocurrencies have a leadership influence over the volatility indices. Our results have important policy implications for enhancing financial stability and deliver valuable insights for deploying volatility-based financial instruments that can potentially provide cryptocurrency investors with suitable hedges, as we show that cryptocurrency and volatility markets are insignificantly (weakly) connected under normal (extreme) market conditions.
Bitcoin: a new proof-of-work system with reduced variance
Authors: Bazzanella Danilo , Gangemi Andrea 
Published: May 2023

AbstractSince its inception, bitcoin has used the popular consensus protocol proof-of-work (PoW). PoW has a well-known flaw: it distributes all rewards to a single miner (or pool) who inserts a new block. Consequently, the variance of rewards and the mining enterprise risk are extremely high. In 2016, Shi proposed addressing this problem with a theoretical algorithm. We introduce an easily-implemented PoW variant that improves Shi’s idea. The network must not find a single nonce but a few to insert a block. This simple change allows for a fairer distribution of rewards and also has the effect of regularizing the insertion time of blocks. This method would facilitate the emergence of small pools or autonomous miners.