bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effect of modified intermittent fasting and daily calorie restriction on sleep quality, anthropometric data, and body composition in women with obesity or overweight: study protocol of a randomized controlled trial
Authors: Hooshiar Saeedeh Hosseini , Yazdani Akram , Jafarnejad Sadegh 
Published: January 2023

Abstract
Background
Sleep disturbances are common in nearly one-third of adults. Both low quality of sleep and sleep time could be related to increased obesity. An increase in visceral adipose tissue can result in the secretion of inflammatory cytokines. Inflammatory cytokines can lead to a disturbance of the sleep-wake rhythm. Therefore, weight loss may improve sleep quality and duration. Intermittent fasting diet as a popular diet reduces body weight and improves anthropometric indices. This study is performed to further investigate the effect of a modified intermittent fasting diet on sleep quality and anthropometric indices.

Methods
This is an open-label randomized controlled trial to evaluate the effect of daily calorie restriction (control) and modified intermittent fasting (intervention) on sleep quality, anthropometric data, and body composition in women with obesity or overweight for 8 weeks. Fifty-six participants will be classified using stratified randomization based on body mass index (BMI) and age. Then, participants will be assigned to one of the two groups of intervention or control using the random numbers table. The sleep quality, daytime sleepiness, and insomnia will be evaluated by using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Insomnia Severity Index respectively. The primary outcomes chosen for the study were as follows: the difference in sleep quality, daytime sleepiness, insomnia, BMI, fat-free mass (FFM), body fat mass, waist circumference, and waist-to-hip ratio from baseline to 8 weeks. Secondary outcomes chosen for the study were as follows: the difference in hip circumference, the visceral fat area, percent body fat, soft lean mass, skeletal muscle mass, extracellular water ratio, and total body water from baseline to 8 weeks.

Discussion
This study will investigate the effect of intermittent fasting intervention compared with daily calorie restriction on sleep quality and anthropometric indices. The information gained will enhance our understanding of fasting interventions, which can be used to improve clinical dietary recommendations. The findings will help to disclose as yet the unknown relationship between diet and sleep quality.

Trial registration
Iranian Registry of Clinical Trials IRCT20220522054958N3. Registered on 8 July 2022. https://www.irct.ir/trial/64510.
Effect of frailty, physical performance, and chronic kidney disease on mortality in older patients with diabetes : a retrospective longitudinal cohort study
Authors: Weng Shuo-Chun , Lin Cheng-Fu , Hsu Chiann-Yi , Lin Shih-Yi 
Published: January 2023

Abstract
Background
Declined renal function is associated with physical function impairment and frailty in a graded fashion. This study aimed to examine the relationship between renal function, frailty and physical performance with mortality in older patients with diabetes, while also determining their combined effects on patient outcome.

Methods
A retrospective longitudinal study was conducted in elderly patients with diabetes. Kidney disease staging was based on clinical practice guidelines of the International Society of Nephrology, and chronic kiney disease (CKD) was defined as urinary albumin to creatinine ratio (UACR) > 30 mg/g, persistent reduction in estimated glomerular filtration rate (eGFR) below 60 mL/min per 1.73 m2 or both. The modified Rockwood frailty index (RFI) was composed of cumulative health deficits, and physical function was determined by handgrip strength (HGS). Additionally, a timed up and go (TUG) test was assessed at baseline. Kaplan-Meier survival and Cox proportional hazard analyses were used to analyze the association between CKD, frailty, physical function and mortality.

Results
For the 921 enrolled patients, their mean age was 82.0 ± 6.7 years. After a median 2.92 (interquartile range [IQR] 1.06–4.43) year follow-up, the survival rate was 67.6% and 85.5% in patients with and without CKD, respectively. The mortality hazard ratio (crude HR) with CKD was 5.92 for those with an RFI higher than 0.313 (95% CI 3.44–10.18), 2.50 for a TUG time longer than 21 s (95% CI 1.22–5.13), and 2.67 for an HGS lower than 10.57 kg in females or 20.4 kg in males (95% CI 1.12–6.37). After multivariate adjustment, the mortality hazard ratio for an RFI ≥ 0.313 was 5.34 (95% CI 2.23–12.80) in CKD patients, but not in patients without CKD. In subgroup analysis, patients experiencing CKD and frailty, or physical function impairment, had the lowest survival proportion followed by only frailty/declined physical function, only CKD, without CKD, and non-frailty/non-physical impairment.

Conclusion
CKD, frailty and physical function impairment were all associated with an increased mortality risk in older patients with diabetes, while the combined effects of these 3 factors were seen on patient outcome.
Plants from a semi-arid environment as a source of phytochemicals against Fusarium crown and foot rot in zucchini
Authors: Khalil Ahmed M. A. , Saleh Ahmed M. , Abo El-Souad Sayed M. S. , Mohamed Mahmoud S. M. 
Published: January 2023

AbstractFusarium crown and foot rot, caused by F. solani f. sp. cucurbitae, are major fungal diseases affecting zucchini and other cucurbits. Despite the efficacy of synthetic fungicides, their health and environmental hazards have highlighted the urgent need for safer alternatives, such as phytochemical-based biocides. Owing to the upregulation of the plant secondary metabolism under stressful conditions, bioprospecting in harsh environments could reveal ore plants for bioactive metabolites. In this study, thirteen wild plants were collected from their natural habitat in a semiarid environment (Yanbu, Saudi Arabia) and extracted to obtain phenolics rich extracts. Total polyphenols, flavonoids, antioxidant capacities and the antifungal activities of the extracts against a pathogenic isolate of F. solani were assessed. Fusarium solani was isolated from infected zucchini and characterized by scanning electron microscopy. Hierarchical clustering analysis of the phytochemical screening and in vitro bioactivity revealed that Rosmarinus officinalis, Pulicaria crispa, Achillea falcata and Haloxylon salicornicum were the richest in polyphenols and the most powerful against F. solani. Further, the extracts of these four plants significantly decreased the disease incidence in zucchini, where P. crispa was the premier. Interestingly, results of transmission electron microscopy revealed that extract of P. crispa, as a representative of the powerful group, induced ultrastructural disorders in fungal cells. Therefore, this study suggests the use of R. officinalis, P. crispa, A. falcata and H. salicornicum grown in semi-arid environments as ore plants to develop phytochemical-based biocides against Fusarium crown and foot rot.
Evaluation method for the hyperspectral image camouflage effect based on multifeature description and grayscale clustering
Authors: He Zhenxin , Gan Yuanying , Ma Shixin , Liu Chuntong , Liu Zhongye 
Published: January 2023

AbstractHyperspectral images have a special attribute with both spectral and spatial information, which is of great significance for the evaluation of the stealth performance of camouflaged targets. Aiming at the problems of a single evaluation index and the low credibility of traditional optical camouflage evaluation methods, this paper proposes a grayscale clustering camouflage effect evaluation method based on multifeature descriptions of hyperspectral images using similarity indicators that reflect different spectral characteristics of the target and background. From the perspective of spectrum and human visual contrast, a comprehensive evaluation index system including spectral distance feature, spectral derivative feature, curve shape feature and spatial texture feature is constructed by combining spatial–spectral multi-feature constraints. At the same time, an improved Delphi method is proposed to simulate the expert decision-making process, and better evaluation weights are obtained by comparison and screening. The comprehensive evaluation of camouflage effect based on whitening function gray clustering is realized. The proposed method can not only give the “excellent” and “bad” of camouflage effect qualitatively, but also calculate the comprehensive score of camouflage effect by model.
Tangent-point energies and ropelength as Gamma-limits of discrete tangent-point energies on biarc curves
Authors: Lagemann Anna , von der Mosel Heiko 
Published: January 2023

AbstractUsing interpolation with biarc curves we prove Γ-convergence of discretized tangent-point energies to the continuous tangent-point energies in the$C^{1}$C1-topology, as well as to the ropelength functional. As a consequence, discrete almost minimizing biarc curves converge to minimizers of the continuous tangent-point energies, and to ropelength minimizers, respectively. In addition, taking point-tangent data from a given$C^{1,1}$C1,1-curveγ, we establish convergence of the discrete energies evaluated on biarc curves interpolating these data, to the continuous tangent-point energy ofγ, together with an explicit convergence rate.
Substance use in rural trauma patients admitted for motor vehicle injuries before and during the COVID-19 pandemic
Authors: Rudisill Toni Marie , Steinmetz Lucie , Bardes James M. 
Published: January 2023

Abstract
Background
Urban trauma centers reported increased substance use among individuals injured in motor vehicle collisions (MVC) after the start of the COVID-19 pandemic. Little is known about individuals admitted to rural trauma centers during this time. This study’s purpose was to describe substance use trends before and during the pandemic among individuals injured in MVC and treated at a rural Level-1 trauma center in West Virginia.

Methods
A cross-sectional analysis was performed using patients’ medical records. The study population included individuals ≥ 18 years of age who received treatment for a motor vehicle-related injury between September 1, 2018, and September 30, 2021, and were tested for drugs and alcohol upon admittance. The pre-COVID-19 period was defined as September 1, 2018–March 15, 2020. The COVID-19 period was March 16, 2020–September 30, 2021. The primary dependent variable was the patients’ drug test results. The primary independent variable was the time period. The data were analyzed using Chi-square tests, logistic regression, and proportional odds models.

Results
During this time, 1465 patients received treatment. On average, patients were 45 years ± 20 of age and male (57%). During COVID-19, 17% of patients tested positive for alcohol and 58% tested positive for non-alcohol drugs. After adjusting for patients’ sex and age, the number of drugs that patients tested positive for was 31% higher during COVID-19 (aOR 1.31; 95% CI 1.08, 1.58). The proportion of patients testing positive for cannabinoids (p = 0.05), opioids (p = 0.001), and stimulants (p = 0.010) increased from pre-COVID-19 to COVID-19 periods.

Conclusions
Drug and alcohol use increased among trauma patients admitted to a rural trauma center during COVID-19. Significant increases were seen in the number of drugs and for cannabinoids, opioids, and stimulants.
Antioxidant, cytotoxic, antibacterial and thrombolytic activities of Centella asiatica L.: possible role of phenolics and flavonoids
Authors: Rashid Md. Harun-Or- , Akter Mst. Mahmuda , Uddin Jalal , Islam Saziya , Rahman Mousumy , Jahan Khurshid , Sarker Md. Moklesur Rahman , Sadik Golam 
Published: January 2023

Abstract
Background
Centella asiatica L. (Apiaceae), a green leafy vegetable, has been used as a popular folk medicine in Bangladesh in the treatment of various ailments. The plant is reported to contain phenolics and flavonoids, but their bioactive potentials are not yet completely known. The present study was designed to investigate the role of the phenolic and flavonoids in the antioxidant, cytotoxicity, antibacterial and thrombolytic activities.

Methods
Four solvent fractions viz. methanol (MSF), ethyl acetate (ESF), chloroform (CSF) and petroleum ether (PSF) were prepared from the dried powder of the whole plant by the modified Kupchan method. Total phenolic content and flavonoid content were determined by Folin Ciocalteu method and aluminum chloride colorimetric method, respectively. The antioxidant activity was assessed by the DPPH radical scavenging and total antioxidant capacity assays. The antibacterial activity was determined by the disc diffusion method and cytotoxicity was evaluated by the brine shrimp lethality bioassay. Thrombolytic activity was assayed using streptokinase as standard.

Results
Qualitative analysis of phytochemical revealed the presence of phenolics and flavonoids along with other bioactive constituents. Among the extractives, CSF contained the highest content of phenolics (155.46 ± 0.52 mg GAE/g) and flavonoids (345.17 ± 1.12 mg QE/g) and exhibited the most potent antioxidant activity in terms of total antioxidant capacity (179.01 ± 0.89 mg AAE/g) and DPPH scavenging ability (IC50; 15.31 ± 0.32 µg/mL). Similarly, CSF showed the highest cytotoxicity with LC50 values of 13.80 ± 0.23 µg/mL, and thrombolytic activity with 43.94 ± 0.62% clot lysis. The fraction also exhibited broad spectrum antibacterial activity. A significant correlation was observed between the flavonoid content and total antioxidant activity (r2 = 0.894, p < 0.05), while high correlation was seen between phenolic and flavonoid content and DPPH radical scavenging, total antioxidant capacity and cytotoxicity (r2 = 0.612–0.928). Similarly, a positive correlation was found between phenolic and flavonoid content with thrombolytic and antibacterial activities.

Conclusion
These results revealed that C. asiatica is a rich source of phenolics and flavonoids and correlated with antioxidant, cytotoxicity, antibacterial and thrombolytic activities. Hence isolation of phenolics and flavonoids from this plant may offer potential candidates which may be effective in the prevention of many chronic diseases.
Cardiac hemangioma presenting as a primary cardiac tumor
Authors: Berdica Leart , Kola Erisa , Nakuci Daniela , Horjeti Edlira , Alimehmeti Mehdi 
Published: January 2023

AbstractCardiac hemangiomas are very rare benign cardiac tumors. They can present at any age and clinical presentation varies according to location and size. We encountered an 87-year-old woman with a left atrial hemangioma clinically diagnosed as cardiac myxoma. Histopathological examination revealed that it was a cavernous-type hemangioma Left atrial hemangiomas, especially those attached to the left atrium wall, may be mistakenly diagnosed as myxomas. Furthermore, a comprehensive review of atrial hemangioma was conducted for the diagnosis and treatment of this uncommon entity.
Integration of artificial intelligence performance prediction and learning analytics to improve student learning in online engineering course
Authors: Ouyang Fan , Wu Mian , Zheng Luyi , Zhang Liyin , Jiao Pengcheng 
Published: January 2023

AbstractAs a cutting-edge field of artificial intelligence in education (AIEd) that depends on advanced computing technologies, AI performance prediction model is widely used to identify at-risk students that tend to fail, establish student-centered learning pathways, and optimize instructional design and development. A majority of the existing AI prediction models focus on the development and optimization of the accuracy of AI algorithms rather than applying AI models to provide student with in-time and continuous feedback and improve the students’ learning quality. To fill this gap, this research integrated an AI performance prediction model with learning analytics approaches with a goal to improve student learning effects in a collaborative learning context. Quasi-experimental research was conducted in an online engineering course to examine the differences of students’ collaborative learning effect with and without the support of the integrated approach. Results showed that the integrated approach increased student engagement, improved collaborative learning performances, and strengthen student satisfactions about learning. This research made contributions to proposing an integrated approach of AI models and learning analytics (LA) feedback and providing paradigmatic implications for future development of AI-driven learning analytics.
Environmental factors affecting akinete germination and resting cell awakening of two cyanobacteria
Authors: Kwon Daeryul , Kim Keonhee , Jo Hyunjin , Lee Sang Deuk , Yun Suk Min , Park Chaehong 
Published: January 2023

AbstractGlobally, cyanobacteria frequently cause blooms that outcompete other species in the waterbody, affecting the diversity, decreasing water exchange rates, and promoting eutrophication that leads to excessive algal growth. Here,Dolichospermum circinale(akinetes) andMicrocystic aeruginosa(resting cells), were isolated from the sediment in the Uiam Dam in the North Han River and near Ugok Bridge in the Nakdong River, respectively. The morphology, germination process and rates, and growth was evaluated in different environmental conditions.D. cercinalisgermination began on day two of culturing, with maximum cell growth observed on day ten. In contrast,M. aeruginosaexhibited daily increase in cell density and colony size, with notable density increase on day six. Next, different environmental conditions were assessed. Akinetes exhibited high germination rates at low light intensity (5—30 µmol/m2/s), whereas resting cells exhibited high growth rates at high light intensity (50—100 µmol/m2/s). Furthermore, both cell types exhibited optimum germination and growth in media containing N and P at 20—30° at a pH of 7—9. Our study reveals the optimum conditions for the germination and growth of cyanobacterial akinetes and resting cells isolated from river sediment, respectively, and will assist in predicting cyanobacterial blooms for appropriate management.
Resolution of Hyperandrogenism, Insulin Resistance and Acanthosis Nigricans (HAIR-AN) Syndrome After Sleeve Gastrectomy
Authors: Lewin Zoe , Vitek Wendy S , O’Malley William , Astapova Olga 
Published: January 2023

Abstract
Hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) is a severe subphenotype of polycystic ovary syndrome (PCOS). A 32-year-old woman with HAIR-AN and class 3 obesity presented to an endocrinology clinic after she failed sequential trials of treatment with metformin, estrogen–progestin OCP, spironolactone, leuprolide, and a levonorgestrel intrauterine device. She complained of hirsutism and acanthosis nigricans severely affecting her quality of life and had secondary amenorrhea. Laboratory evaluation showed extremely elevated testosterone and insulin levels and elevated glycated hemoglobin A1c (HbA1c). She underwent laparoscopic sleeve gastrectomy. One year after the surgery, she lost 32% of her body weight and reported normalization of menses, dramatic improvement in hirsutism, and near-resolution of acanthosis nigricans. Her testosterone, insulin, and HbA1c normalized. This case demonstrates the central role of hyperinsulinemia in HAIR-AN and suggests that aggressive measures to normalize insulin resistance and reduce excess weight can effectively treat the reproductive abnormalities in this syndrome. We suggest that bariatric surgery can be an effective cure for HAIR-AN syndrome and that PCOS, including HAIR-AN, should be considered a comorbidity of obesity during evaluation of bariatric surgery candidates.
Project Management Based on the Analysis of Business Processes and the Main Trends in the Development of Commercial Banks
Authors: Zotova E. 
Published: January 2023

As a result of the changes that have affected to a large extent the entire banking system of the Russian Federation, banks were forced to rebuild the proven algorithms and automated management platforms. The reason for this is the import substitution of the software used as a result of the depar-ture of the main vendors of foreign automated systems that were used by Russian banks. At the same time, many banks faced a situation in which the accepted software from Russian developers was difficult to integrate into the management environment of their business processes. At the same time, each bank solves this problem in its own way, while software develop-ers bring new products to the market, often not taking into account the inter-ests of banks, which together leads to problems in adapting the proposed software to the required functionality. Without studying the specifics of the business processes of modern banking organizations, many solutions re-main unclaimed.
Therefore, it is relevant to study business processes and trends in the de-velopment of commercial processes in the banking sector, which will allow modern developers to more clearly and clearly introduce systems to the market that help meet all the needs of financial organizations.
This article presents the capabilities of Russian developers to integrate modern software into the business processes of the banking sector, which will, to a certain extent, solve the problems associated with the withdrawal of foreign vendors from the market. The study will determine the capabilities of banks and is aimed at ensuring that developers also take into account the interests and specifics of the commercial processes of the banking sec-tor, which together will allow building the most effective digital management platforms.
Mortality and clinical outcomes of Vancouver type B periprosthetic femoral fractures
Authors: Takami Hideomi , Takegami Yasuhiko , Tokutake Katsuhiro , Kurokawa Hiroshi , Iwata Manato , Terasawa Satoshi , Oguchi Takeshi , Imagama Shiro 
Published: January 2023

Aims The objectives of this study were to investigate the patient characteristics and mortality of Vancouver type B periprosthetic femoral fractures (PFF) subgroups divided into two groups according to femoral component stability and to compare postoperative clinical outcomes according to treatment in Vancouver type B2 and B3 fractures. Methods A total of 126 Vancouver type B fractures were analyzed from 2010 to 2019 in 11 associated centres' database (named TRON). We divided the patients into two Vancouver type B subtypes according to implant stability. Patient demographics and functional scores were assessed in the Vancouver type B subtypes. We estimated the mortality according to various patient characteristics and clinical outcomes between the open reduction internal fixation (ORIF) and revision arthroplasty (revision) groups in patients with unstable subtype. Results The one-year mortality rate of the stable and unstable subtype of Vancouver type B was 9.4% and 16.4%. Patient demographic factors, including residential status and pre-injury mobility were associated with mortality. There was no significant difference in mortality between patients treated with ORIF and Revision in either Vancouver B subtype. Patients treated with revision had significantly higher Parker Mobility Score (PMS) values (5.48 vs 3.43; p = 0.00461) and a significantly lower visual analogue scale (VAS) values (1.06 vs 1.94; p = 0.0399) for pain than ORIF in the unstable subtype. Conclusion Among patients with Vancouver type B fractures, frail patients, such as those with worse scores for residential status and pre-injury mobility, had a high mortality rate. There was no significant difference in mortality between patients treated with ORIF and those treated with revision. However, in the unstable subtype, the PMS and VAS values at the final follow-up examination were significantly better in patients who received revision. Based on postoperative activities of daily life, we therefore recommend evision in instances when either treatment option is feasible. Cite this article: Bone Jt Open 2023;4(1):38–46.