bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for emergence agitation during the awakening period in elderly patients after total joint arthroplasty: a retrospective cohort study
Authors: Wang Naigeng , Hao Jianhong , Zhang Jie , Du Jing , Luo Zhenguo 
Published: May 2023

ObjectivesThis study aimed to explore the incidence and risk factors for emergence agitation (EA) in elderly patients who underwent total joint arthroplasty (TJA) under general anaesthesia, and to assess their predictive values.DesignSingle-centre retrospective cohort study.SettingA 1600-bed general tertiary hospital in China.ParticipantsThis study enrolled 421 elderly patients scheduled for elective primary TJA under general anaesthesia.Primary and secondary outcome measuresEA was assessed using the Richmond Agitation Sedation Scale during the awakening period after surgery in the post-anaesthesia care unit. Risk factors for EA were identified using univariate and multivariable logistic analyses. The receiver operating characteristic (ROC) curve was used to assess the predictive values of the risk factors for EA.ResultsThe incidence of EA in elderly patients who underwent TJA was 37.6%. According to the multivariable logistic analysis, postoperative pain (95% CI: 1.951 to 3.196), male sex (95% CI: 1.781 to 6.435), catheter-related bladder discomfort (CRBD) (95% CI: 4.001 to 15.392) and longer fasting times for solids (95% CI: 1.260 to 2.301) and fluids (95% CI: 1.263 to 2.365) were independent risk factors for EA. As shown by the ROC analysis, postoperative pain and fasting times for solids and fluids had good predictive values, with areas under the ROC curve equalling 0.769, 0.753 and 0.768, respectively.ConclusionsEA is a common complication after TJA in elderly patients. Some risk factors, including postoperative pain, male sex, CRBD and longer fasting times, can increase the incidence of EA. These risk factors may contribute to identifying high-risk patients, which facilitates the development of effective strategies to prevent and treat EA.Trial registration numberChiCTR1800020193.
Role of security guards in healthcare settings: a protocol for a systematic review
Authors: Shongwe Lindokuhle , Hanft-Robert Saskia , Cossie Qhama , Sithole Philasande , Roos Tessa , Swartz Leslie 
Published: May 2023

IntroductionThere is a paucity of literature on the comprehensive roles of security guards in healthcare, regardless of day-to-day observations of security guards playing an extensive role in this field. Thus, this review will systematically explore the roles of security guards in healthcare contexts to create a centred body of evidence.Methods and analysisThe study will systematically review existing quantitative and qualitative peer-reviewed literature on security guards in institutional healthcare so as to understand their roles. We will conduct the systematic review on 10 electronic databases: BioMed Central, SocIndex, ScienceDirect, Google Scholar, JSTOR, PsycARTICLES, PsycINFO, Scopus, Web of Science and PubMed. Data extraction will be in the form of a word document. Mendeley software will be used to keep track of references, while the systematic review software, Rayyan, will be used for the screening, inclusion and exclusion of articles. If necessary, reviewer number 3 will conduct a third review should any disputes arise between the two initial reviewers. Quality assessment of the articles will be measured with the Critical Appraisal Skills Programme tool for articles in terms of the research aims, methodology used, sample, data analysis, presentation of findings, values of the research, as well as trustworthiness if it is a qualitative study or reflexiveness if it is a quantitative study. Studies dating back 32 years will be incorporated for a comprehensive review.Ethics and disseminationThis systematic review will use publicly available peer-reviewed data from electronic databases and will, therefore, not require an ethical review, but rather, an ethics waiver. The systematic review protocol will be submitted for ethics waiver clearance from the Stellenbosch University Health Research Ethics Committee. The findings from this review will be disseminated through peer-reviewed publications and conferences.PROSPERO registration numberCRD42022353653.
Effectiveness of eHealth therapeutic education interventions in the management of fibromyalgia: protocol for a systematic review and meta-analysis
Authors: Martínez-Navarro Oriol , Climent-Sanz Carolina , Lletjà-Guijarro Ariadna , Adel El Arab Rabie , Verdejo-Amengual Francisco José , Valenzuela-Pascual Fran 
Published: May 2023

IntroductionNon-pharmacological approaches have shown promising results in improving symptoms and quality of life of patients with fibromyalgia. However, these approaches may not be easily accessible or feasible for everyone. eHealth interventions may offer a more convenient and cost-effective approach to reach a wider range of patients with fibromyalgia and improve their outcomes. As eHealth tools become more prevalent in clinical practice, it is crucial to understand their effectiveness, limitations and how they can be integrated into standard care to optimise clinical outcomes. This systematic review aims to evaluate the effectiveness of eHealth therapeutic education interventions in managing fibromyalgia.Methods and analysisRandomised controlled trials including eHealth therapeutic education interventions for individuals ≥18 years old with fibromyalgia, published in English or Spanish, will be retrieved by searching the databases PubMed, CINAHL Plus, EMBASE, Scopus, ISI Web of Science, PsycINFO and the Cochrane Central Register of Controlled Trials. Covidence software will be used for the selection of studies and data extraction. The risk of bias and the certainty of evidence will be assessed using the Cochrane Risk of Bias Assessment tool. We plan to perform a meta-analysis contingent on the number of studies retrieved and the interstudy heterogeneity, which will be explored with I2statistics.Ethics and disseminationThis protocol and the subsequent systematic review will not collect individual-level data and do not require approval by an ethical committee. We intend to disseminate the study results via peer-reviewed scientific journals and relevant (inter)national conferences.PROSPERO registration numberCRD42022343373.
Triple burden of malnutrition among mother–child pairs in low-income and middle-income countries: a cross-sectional study
Authors: Chilot Dagmawi , Belay Daniel Gashaneh , Merid Mehari Woldemariam , Kibret Anteneh Ayelign , Alem Adugnaw Zeleke , Asratie Melaku Hunie , Teshager Nahom Worku , Aragaw Fantu Mamo 
Published: May 2023

ObjectiveThis study aimed to assess the prevalence and determinants of the triple burden of malnutrition among mother–child pairs in low-income and middle-income countries.DesignCross-sectional study.SettingLow-income and middle-income countries.ParticipantsWomen and children.Primary outcomeTriple burden of malnutrition (overweight/obese mother with undernourished and anaemic under 5 years child).MethodsData for this study were drawn from recent 22 low-income and middle-income countries Demographic and Health Surveys. A total weighted sample of 116 795 mother–child pairs was included in the study. STATA V.14.2 was used to clean, code and analyse the data. Multilevel logistic regression was employed to identify factors associated with the problem. Adjusted OR (AOR) with 95% CI and a p<0.05 was reported to indicate statistical association. Model fitness and comparison were done using intraclass correlation coefficient, median OR, proportional change in variance and deviance.ResultThe pooled prevalence of the triple burden of malnutrition among mother–child pairs was 11.39%. It showed statistically significant positive associations with mothers aged ≥35 years (AOR 2.25, 95% CI 2.08 to 2.44), family size >10 (AOR 1.17, 95% CI 1.08 to 1.26), delivery by caesarean section (AOR 1.93, 95% CI 1.83 to 2.03), the richest household (AOR 1.72, 95% CI 1.56 to 1.88), grand multiparous (AOR 1.62, 95% CI 1.46 to 1.81), age of child 36–47 months (AOR 1.77, 95% CI 1.64 to 1.90), at a p<0.05. Whereas breast feeding (AOR 0.94, 95% CI 0.89 to 0.99), married mothers (AOR 0.87, 95% CI 0.78 to 0.96), female children (AOR 0.88, 95% CI 0.84 to 0.92), improved toilet (AOR 0.23, 95% CI 0.17 to 0.29), improved source of drinking water (AOR 0.28, 95% CI 0.21 to 0.35), rural residents (AOR 0.66, 95% CI 0.62 to 0.69) had a contrasting relationship with the triple burden of malnutrition.ConclusionAbout 1 out of 10 households suffer from the triple burden of malnutrition in low-income and middle-income countries. This study revealed that several maternal, child, household and community-level factors have a significant impact on the triple burden of malnutrition among mother–child pairs.
Alcohol and substance dependence in the United Arab Emirates: a scoping review protocol
Authors: Fouché Ansie , Albrithen Abdulaziz , AlNuaimi Mariam , Al Riyami Khoula , Aruldoss Vinnarasan , Cooper Krista , Marta Raquel , Tedam Prospera 
Published: May 2023

IntroductionDespite cultural, religious and legal constraints, alcohol and drug abuse is rising in the United Arab Emirates (UAE). Therefore, we aim to produce a scoping review to summarise available scientific literature on alcohol and substance dependence (ASD) in all ethnic and religious groups in the UAE to inform future scientific inquiries.Methods and analysisSocial work faculty from the UAE University will conduct the scoping review between March 2023 and February 2024. Drawing on the participants, concept, context (PCC) framework, the following review question was developed: What can be learnt from a review of scientific literature on alcohol and substance abuse in all ethnic and religious groups in the UAE? The scientific literature on ASD in the UAE published between 1971 and January 2023, in either English or Arabic, will be considered, including all ethnic, religious and age groups. Grey literature, such as postgraduate dissertations and conference proceedings, will also be considered. Eight English and two Arabic databases and print copies of literature sources in university libraries will be included. EndNote and Covidence software will be used for deduplication, screening and data extraction. Screening and reviewing search results will involve two English-speaking and two Arabic-speaking team members who will work independently. A third reviewer will resolve conflicts. The inter-rater reliability data from the title and abstract screening stage will be exported, and Cohen’s kappa coefficient will be calculated. Data charting informed by the Covidence data extraction tool 2.0 will occur after pilot testing, followed by qualitative content analysis. Reporting of the findings will align with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews tool.Ethics and disseminationEthical approval is not required for this study because this is a scoping review of published studies and grey literature. Findings will be disseminated via peer-reviewed journal publications, scientific conferences and a policy brief.
Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study
Authors: Kent Thomas , Sinha Vikash , Ceyhan Elvan , Sura Livia , Yekeler Ensar , Weiss Michael David , Albayram Mehmet 
Published: May 2023

PurposeGerminal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal variants in preterm deep cerebral venous anatomy associated with GMH-IVH have been previously described using MRI susceptibility weighted imaging (SWI). The aims of this study were to use SWI to compare the deep venous systems of a cohort of preterm neonates with various grades of GMH-IVH to a group of age-matched controls without GMH-IVH and to present novel retrospective SWI imaging findings.MethodsA neuroradiologist retrospectively evaluated 3T MRI SWI and phase imaging of 56 preterm neonates with GMH-IVH (14 of each grade) and 27 controls without GMH-IVH, scoring the venous irregularities according to three variables: decreased venous patency, increased lumen susceptibility and the presence of collaterals. Eight different venous locations, including indicated bilateral components, were evaluated: straight sinus, vein of galen, internal cerebral, direct lateral, thalamostriate, atrial and the anterior septal veins. Variables were analysed for statistical significance. Inter-rater reliability was determined via subset evaluation by a second paediatric radiologist.ResultsDeep venous abnormalities were significantly more common in patients with GMH-IVH, with Wilcoxon Rank Sum Test demonstrating significant increase with GMH-IVH for total decreased venous patency (W=0, p<0.0001), increased lumen susceptibility and collateral formation. Venous abnormalities were also positively correlated with an increase in GMH-IVH grade from I to IV (patency, ρ=0.782, p<0.01) (increased lumen susceptibility, ρ=0.739, p<0.01) (collaterals, ρ=0.649, p<0.01), not just GMH-IVH alone.ConclusionDeep venous abnormalities are significantly correlated with GMH-IVH alone and an increase in GMH-IVH grade. Further study is needed to determine cause and effect.
Brady- and tachyarrhythmias detected by continuous rhythm monitoring in paroxysmal atrial fibrillation
Authors: Frausing Maria Hee Jung Park , Van De Lande Martijn E , Maass Alexander H , Nguyen Bao-Oanh , Hemels Martin E W , Tieleman Robert G , Koldenhof Tim , De Melis Mirko , Linz Dominik , Schotten Ulrich , Weberndörfer Vanessa , Crijns Harry J G M , Van Gelder Isabelle C , Nielsen Jens Cosedis , Rienstra Michiel 
Published: May 2023

ObjectiveAtrial fibrillation (AF) is associated with adverse events including conduction disturbances, ventricular arrhythmias and sudden death. The aim of this study was to examine brady- and tachyarrhythmias using continuous rhythm monitoring in patients with paroxysmal self-terminating AF (PAF).MethodsIn this multicentre observational substudy to the Reappraisal of Atrial Fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V), we included 392 patients with PAF and at least 2 years of continuous rhythm monitoring. All patients received an implantable loop recorder, and all detected episodes of tachycardia ≥182 beats per minute (BPM), bradycardia ≤30 BPM or pauses ≥5 s were adjudicated by three physicians.ResultsOver 1272 patient-years of continuous rhythm monitoring, we adjudicated 1940 episodes in 175 patients (45%): 106 (27%) patients experienced rapid AF or atrial flutter (AFL), pauses ≥5 s or bradycardias ≤30 BPM occurred in 47 (12%) patients and in 22 (6%) patients, we observed both episode types. No sustained ventricular tachycardias occurred. In the multivariable analysis, age >70 years (HR 2.3, 95% CI 1.4 to 3.9), longer PR interval (HR 1.9, 1.1–3.1), CHA2DS2-VASc score ≥2 (HR 2.2, 1.1–4.5) and treatment with verapamil or diltiazem (HR 0.4, 0.2–1.0) were significantly associated with bradyarrhythmia episodes. Age >70 years was associated with lower rates of tachyarrhythmias.ConclusionsIn a cohort exclusive to patients with PAF, almost half experienced severe bradyarrhythmias or AF/AFL with rapid ventricular rates. Our data highlight a higher than anticipated bradyarrhythmia risk in PAF.Trial registration numberNCT02726698.
Effects of clopidogrel bisulfate on B16-F10 cells and tumor development in a murine model of melanoma
Authors: Jantsch Matheus Henrique , Doleski Pedro Henrique , Viana Altevir Rossato , da Silva Jean Lucas Gutknecht , Passos Daniela Ferreira , Cabral Fernanda Licker , Manzoni Alessandra Guedes , Ebone Renan da Silva , Soares Ana Bárbara Uchoa , de Andrade Cínthia Melazzo , Schetinger Maria Rosa Chitolina , Leal Daniela Bitencourt Rosa 
Published: May 2023

Summary Metastatic melanoma is a very aggressive skin cancer. Platelets are constituents of the tumor microenvironment and, when activated, contribute to cancer progression, especially metastasis and inflammation. P2Y12 is an adenosine diphosphate receptor that triggers platelet activation. Inhibition of P2Y12 by clopidogrel bisulfate (CB) decreases platelet activation, which is also controlled by the extracellular concentration and the metabolism of purines by purinergic enzymes. We evaluated the effects of CB on the viability and proliferation of cultured B16-F10 cells. We also used a metastatic melanoma model with C57BL-6 mice to evaluate cancer development and purine metabolism modulation in platelets. B16-F10 cells were administered intraperitoneally to the mice. Two days later, the animals underwent a 12-day treatment with CB (30 mg/kg by gavage). We have found that CB reduced cell viability and proliferation in B16-F10 culture in 72 h at concentrations above 30 µm. In vivo, CB decreased tumor nodule counts and lactate dehydrogenase levels and increased platelet purine metabolism. Our results showed that CB has significant effects on melanoma progression.
Study of X(6900) with unitarized coupled channel scattering amplitudes
Authors: Kuang Shi-Qing , Zhou Qi , Guo Di , Yang Qin-He , Dai Ling-Yun 
Published: May 2023

AbstractIn this paper, we study the resonant stateX(6900). The scattering amplitudes of coupled channels,$$J/\psi J/\psi $$J/ψJ/ψ-$$J/\psi \psi (2S)$$J/ψψ(2S)-$$J/\psi \psi (3770)$$J/ψψ(3770), are constructed with the interaction of four vector mesons described by effective Lagrangians. The amplitudes are calculated up to one loop, decomposed by partial wave projection, and unitarized by Pad$$\acute{e}$$e´approximation. These amplitudes are fitted to the latest experimental data sets of di-$$J/\psi $$J/ψand$$J/\psi \psi (2S)$$J/ψψ(2S)invariant mass spectra of LHCb, CMS, and ATLAS. High-quality solutions are obtained. With these partial wave amplitudes, we extract the pole parameters of theX(6900). Its quantum number is likely to be$$0^{++}$$0++. According to the pole counting rule as well as analysis of the phase shifts of the partial waves, it supports our previous conclusion that theX(6900) prefers to be a compact tetra-quark.
Algorithms for Right-sizing Heterogeneous Data Centers
Authors: Albers Susanne , Quedenfeld Jens 
Published: May 2023

Power consumption is a dominant and still growing cost factor in data centers. In time periods with low load, the energy consumption can be reduced by powering down unused servers. We resort to a model introduced by Lin, Wierman, Andrew, and Thereska [
23
,
24
] that considers data centers with identical machines and generalize it to heterogeneous data centers with
d
different server types. The operating cost of a server depends on its load and is modeled by an increasing, convex function for each server type. In contrast to earlier work, we consider the discrete setting, where the number of active servers must be integral. Thereby, we seek truly feasible solutions. For homogeneous data centers (
d
=1), both the offline and the online problem were solved optimally in References [
3
,
4
].

In this article, we study heterogeneous data centers with general time-dependent operating cost functions. We develop an online algorithm based on a work function approach that achieves a competitive ratio of 2
d
+ 1 + ε for any ε > 0. For time-independent operating cost functions, the competitive ratio can be reduced to 2
d
+ 1. There is a lower bound of
2d
shown in Reference [
5
], so our algorithm is nearly optimal. For the offline version, we give a graph-based (1+ε)-approximation algorithm. Additionally, our offline algorithm is able to handle time-variable data-center sizes.
Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey
Authors: Pezeshkian Fatemehsadat , Pouryousef Ali , Omidian Mostafa , Mikaeili Fattaneh , Safarpour Ali Reza , Shojaei-Zarghani Sara , Sarkari Bahador 
Published: May 2023

Toxocariasis as a common neglected disease is the culprit of infecting all age groups. The current cross-sectional study was designed to assess the seroprevalence of toxocariasis and risk factors associated with seropositivity of Toxocara infection among the general population of adults in the Kavar district, south of Iran. A total of 1060 participants with an age range of 35 to 70 years from the Kavar region entered the study. Manual ELISA was utilized to detect anti-Toxocara-specific antibodies in their serum samples. In addition, demographic information as well as risk factors related to toxocariasis was collected from individuals who participated in the survey. The mean age of the participants was 48.9 (±7.9) years old. Out of 1060 subjects, 532 (50.2%) were men, and 528 (49.8%) were women. The overall Toxocara seroprevalence was 5.8% (61/1060). The prevalence of Toxocara seropositive cases was significantly different between males and females (

p

= 0.023). The seropositive rate for Toxocara infection was also significantly higher in housewives (

p

= 0.003) and subjects with learning disabilities (

p

= 0.008). Multivariable logistic regression revealed that housewives (OR = 2.04, 95% CI: 1.18–3.51,

p

= 0.010) and subjects with learning disability (OR = 3.32, 95% CI: 1.29–8.52,

p

= 0.013) were at increased risk of Toxocara infection. The findings of the current study depicted a noticeable seroprevalence of Toxocara infection in the general population in the Kavar district, southern Iran. An increased risk of toxocariasis has been associated with learning disabilities and being a housewife. All of the toxocariasis-positive cases had contact with animals, at some point in their life. In perspective, it is necessary to raise awareness of this infection among the population while surveilling Toxocara infection in high-risk groups.
Dissecting Intra-tumor Heterogeneity in the Glioblastoma Microenvironment Using Fluorescence-Guided Multiple Sampling
Authors: García-Montaño Leopoldo A. , Licón-Muñoz Yamhilette , Martinez Frank J. , Keddari Yasine R. , Ziemke Michael K. , Chohan Muhammad O. , Piccirillo Sara G.M. 
Published: May 2023

Abstract
The treatment of the most aggressive primary brain tumor in adults, glioblastoma (GBM), is challenging due to its heterogeneous nature, invasive potential, and poor response to chemo- and radiotherapy. As a result, GBM inevitably recurs and only a few patients survive 5 years post-diagnosis. GBM is characterized by extensive phenotypic and genetic heterogeneity, creating a diversified genetic landscape and a network of biological interactions between subclones, ultimately promoting tumor growth and therapeutic resistance. This includes spatial and temporal changes in the tumor microenvironment, which influence cellular and molecular programs in GBM and therapeutic responses. However, dissecting phenotypic and genetic heterogeneity at spatial and temporal levels is extremely challenging, and the dynamics of the GBM microenvironment cannot be captured by analysis of a single tumor sample. In this review, we discuss the current research on GBM heterogeneity, in particular, the utility and potential applications of fluorescence-guided multiple sampling to dissect phenotypic and genetic intra-tumor heterogeneity in the GBM microenvironment, identify tumor and non-tumor cell interactions and novel therapeutic targets in areas that are key for tumor growth and recurrence, and improve the molecular classification of GBM.