bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury
Authors: Tang Girdwood Sonya , Hasson Denise , Caldwell J Timothy , Slagle Cara , Dong Shun , Fei Lin , Tang Peter , Vinks Alexander A , Kaplan Jennifer , Goldstein Stuart L 
Published: December 2022

Abstract

Background
Piperacillin/tazobactam, a commonly used antibiotic, is associated with acute kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains unknown.

Objective
Estimate piperacillin exposures in critically ill children and young adults administered piperacillin/tazobactam to identify concentrations and clinical factors associated with piperacillin-associated AKI.

Patients and methods
We assessed piperacillin pharmacokinetics in 107 patients admitted to the paediatric ICU who received at least one dose of piperacillin/tazobactam. Piperacillin AUC, highest peak (Cmax) and highest trough (Cmin) in the first 24 hours of therapy were estimated. Piperacillin-associated AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) Stage 2/3 AKI present &gt;24 hours after initial piperacillin/tazobactam dose. Likelihood of piperacillin-associated AKI was rated using the Naranjo Adverse Drug Reaction Probability Scale. Multivariable logistic regression was performed to identify patient and clinical predictors of piperacillin-associated AKI.

Results
Out of 107 patients, 16 (15%) were rated as possibly or probably having piperacillin-associated AKI. Estimated AUC and highest Cmin in the first 24 hours were higher in patients with piperacillin-associated AKI (2042 versus 1445 mg*h/L, P = 0.03; 50.1 versus 10.7 mg/L, P &lt; 0.001). Logistic regression showed predictors of piperacillin-associated AKI included higher Cmin (OR: 5.4, 95% CI: 1.7–23) and age (OR: 1.13, 95% CI: 1.05–1.25).

Conclusions
We show a relationship between estimated piperacillin AUC and highest Cmin in the first 24 hours of piperacillin/tazobactam therapy and piperacillin-associated AKI, suggesting total piperacillin exposure early in the course is associated with AKI development. These data could serve as the foundation for implementation of model-informed precision dosing to reduce AKI incidence in patients given piperacillin/tazobactam.
Characterizing the relative frequency of clinician engagement with structured social determinants of health data
Authors: Iott Bradley E , Adler-Milstein Julia , Gottlieb Laura M , Pantell Matthew S 
Published: December 2022

AbstractObjectiveElectronic health records (EHRs) are increasingly used to capture social determinants of health (SDH) data, though there are few published studies of clinicians’ engagement with captured data and whether engagement influences health and healthcare utilization. We compared the relative frequency of clinician engagement with discrete SDH data to the frequency of engagement with other common types of medical history information using data from inpatient hospitalizations.Materials and MethodsWe created measures of data engagement capturing instances of data documentation (data added/updated) or review (review of data that were previously documented) during a hospitalization. We applied these measures to four domains of EHR data, (medical, family, behavioral, and SDH) and explored associations between data engagement and hospital readmission risk.ResultsSDH data engagement was associated with lower readmission risk. Yet, there were lower levels of SDH data engagement (8.37% of hospitalizations) than medical (12.48%), behavioral (17.77%), and family (14.42%) history data engagement. In hospitalizations where data were available from prior hospitalizations/outpatient encounters, a larger proportion of hospitalizations had SDH data engagement than other domains (72.60%).DiscussionThe goal of SDH data collection is to drive interventions to reduce social risk. Data on when and how clinical teams engage with SDH data should be used to inform informatics initiatives to address health and healthcare disparities.ConclusionOverall levels of SDH data engagement were lower than those of common medical, behavioral, and family history data, suggesting opportunities to enhance clinician SDH data engagement to support social services referrals and quality measurement efforts.
Growth curve modeling of virtual events and online engagement in a palliative care peer support online health community for adolescents and young adults
Authors: Walker Andrew L , Swygert Anna , Marchi Emily , Lebeau Kelsea , Haardörfer Regine , Livingston Melvin D 
Published: December 2022

AbstractObjectiveOnline health communities (OHCs) have been identified as important outlets for social support and community connection for adolescents and young adults (AYAs) living with chronic illnesses. Despite evident benefits, there remains a gap in research on methods to maximize sustained patient engagement within OHCs. This study assessed per-patient daily commenting rates over time, as well as associations with program staff and volunteer-facilitated events and engagement.Materials and MethodsWe utilized data from 662 daily patient, volunteer, and staff comment totals within a Discord server hosted through the Streetlight at UF Health Streetlight Gaming and Online Team, between January 2019 and January 2022. Multilevel models were used to assess per-patient daily commenting rates and examine associations with OHC-level predictors of staff and volunteer-facilitated daily and seasonal events, as well as the number of daily active users.ResultsPer-patient comment rates showed an overall negative slope with time in most models. Unadjusted and adjusted growth curve models showed that daily events (β = .21), seasonal events (β = .18), and total daily active users (β = .09) were all significantly associated with increases in per-patient daily comment rates.DiscussionResults suggest that social event facilitation strategies can be applied to increase AYA patient engagement in OHCs. Seasonal events and staff and volunteer engagement may be the effective means of maintaining engagement among long-term patients.ConclusionOur findings highlight the importance of staff and volunteer presence in OHCs in driving long-term patient engagement and in considering patient needs and perspectives in developing OHC features.
Characterization of the enzymatic properties of human RNPEPL1/aminopeptidase Z
Authors: Ohnishi Atsushi , Tsujimoto Masafumi 
Published: December 2022

Abstract
It is now evident that the M1 family of aminopeptidases play important roles in many pathophysiological processes. Among them, the enzymatic properties of arginyl aminopeptidase-like 1 (RNPEPL1) are characterized only by its truncated form. No peptide substrate has been identified. To characterize the enzymatic properties of RNPEPL1 in more detail, the full-length protein was expressed in Escherichia coli and purified to homogeneity. The full-length RNPEPL1 showed rather restricted substrate specificity and basic amino acid preference towards synthetic substrates, which was different from the previously reported specificity characterized by the truncated form. Searching for peptide substrates, we found that several peptides, such as Met-enkephalin and kallidin, were cleaved. RNPEPL1 cleaved bradykinin to de-[Arg]-bradykinin despite the presence of proline at the P2’-position. The enzyme cleaved Met-enkephalin but not dynorphin A1–17. Similar to aminopeptidase B, the full-length RNPEPL1 showed basic amino acid preference towards both synthetic and peptide substrates. In addition to the unusual cleavage of bradykinin, this enzyme shows chain length-dependent cleavage of peptide substrates sharing N-terminal amino acid sequence. This is the first study to report the enzymatic properties of the full-length human RNPEPL1 as an aminopeptidase enzyme.
History Does Not Repeat Itself; It Rhymes: Range Expansion and Outbreak of Plecia longiforceps (Diptera: Bibionidae) in East Asia
Authors: Kim Sangil , Jung Seunghun , Choi Jonghwan , Tsai Cheng-Lung , Farrell Brian D , Shin Seunggwan 
Published: December 2022

Abstract
Plecia longiforceps Duda (Diptera: Bibionidae) is reported for the first time from Korea. P. longiforceps has been previously known from the East Asian subtropics, south of the 33rd parallel, including southeastern China, Taiwan, and the Ryukyu Islands of Japan. An integrative taxonomic approach based on morphological examination of male genitalia and molecular analysis of mitochondrial cytochrome c oxidase subunit I gene sequences confirms the species identification. The recent outbreak of P. longiforceps in the Seoul Metropolitan Area, Korea, documented herein represents the northernmost record of this species and suggests its possible range expansion into the temperate zone. Similar to the range expansion and outbreak history of Plecia nearctica Hardy (Diptera: Bibionidae) in North America around the Gulf of Mexico in the 1960–1970s, P. longiforceps may become a new invasive pest in temperate East Asia. Here, we evaluate range expansion and invasion potential of P. longiforceps through Ensemble species distribution modeling and show that a great portion of Northeast Asia and Japan will likely become habitable for P. longiforceps in the next 50 years.
Attitudes About Honey Bees and Pollinator-Friendly Practices: A Survey of Iowan Beekeepers, Farmers, and Landowners
Authors: Cass Randall P , Hodgson Erin W , O’Neal Matthew E , Toth Amy L , Dolezal Adam G 
Published: December 2022

Abstract
The north central state of Iowa is heavily dominated by agriculture, with limited nesting and foraging habitat for wild and managed pollinators. This region has been identified as critical for pollinator conservation for bees and non-bee species (e.g., monarch butterfly [Danaus plexippus]). Pollinator sustainability (i.e., wild bee conservation and sustainable beekeeping) relies upon management decisions by beekeepers, farmers, and landowners, but it is unclear if these stakeholders are aware of and use best practices. We present results of surveys administered to Iowan beekeepers, farmers, and landowners after extension programming on best management practices for sustaining honey bees (Apis mellifera) and other pollinators. Results show beekeepers, farmers, and landowners believe implementing pollinator-friendly practices is important. However, knowledge of tools to implement these practices, such as registering apiaries to avoid pesticide drift or cost-share programs for establishing habitat on their land, was very low. These results suggest opportunities exist for connecting beekeepers seeking higher quality apiaries with landowners that have established habitat with added floral resources. Further, we reviewed practices that reconstruct tallgrass prairie with support of federal cost-share funds, specifically CP42 and CP43 of the USDA’s conservation reserve program. Overall, we document strong support and enthusiasm for pollinator-friendly practices in Iowa but note gaps in knowledge of practices that are most effective and what tools are available to implement them. These results suggest a way for pollinator extension programs to address these knowledge gaps in a receptive group of beekeepers, farmers, and landowners.
Risk factors for long-term decline in post-operative pulmonary function after lung resection
Authors: Tsubokawa Norifumi , Mimura Takeshi , Tadokoro Kazuki , Yamashita Yoshinori 
Published: December 2022

AbstractObjectivesThe study aimed to examine the risk factors for long-term decline in pulmonary function after anatomical resection for lung cancer and the effects of the decrease on survival.MethodsWe retrospectively examined 489 patients who underwent anatomical resection for lung cancer between 2010 and 2020. Pulmonary function tests were performed preoperatively and at 1, 3, 6 and 12 months after surgery. The lower interquartile medians of the reduction rates of forced expiratory volume in 1 s and vital capacity at 12 months after surgery were taken as the cut-off values of risk factors for the decrease in post-operative pulmonary function.ResultsForced expiratory volume in 1 s and vital capacity decreased the most in the first month after surgery and then gradually recovered. Vital capacity continued to increase even after 6 months post-surgery, whereas forced expiratory volume in 1 s stabilized. Multivariable logistic analysis showed that the number of resected segments (odds ratio, 2.09; 95% confidence interval, 1.12–3.89; P = 0.019) was a risk factor for the decrease in forced expiratory volume in 1 s at 12 months, and the numbers of resected segments (odds ratio, 1.36; 95% confidence interval, 1.13–1.63; P &lt; 0.001) and post-operative complications (odds ratio, 2.32; 95% confidence interval, 1.01–5.35; P = 0.047) were independent risk factors for decrease in vital capacity. Multivariate cox regression analysis showed that the decrease in vital capacity at 12 months was significantly associated with overall survival (hazard ratio, 2.02; 95% confidence interval, 1.24–3.67; P = 0.004).ConclusionsLong-term decrease in vital capacity, which was influenced by the number of resected segments and post-operative complications, adversely affected survival.
Correlation of oral mucosa dose and volume parameters with Grade 3 mucositis, in patients treated with volumetric modulated arc radiotherapy for oropharyngeal cancer?
Authors: Bansal Anshuma , Bedi Neeru , Kaur Ripanpreet , Singh Gurpreet , Benipal Raja Paramjeet Singh , Dangwal Vinod 
Published: December 2022

AbstractBackgroundOral mucositis is the dose-limiting toxicity of chemoradiation in oropharyngeal cancer patients, which can be minimized by giving constraints to oral mucosa. However, the constraints defined in literature are extrapolated from chemoradiation in head and neck cancers as a whole. This study aims to determine oral mucosa dose-volume parameters that can predict grade ≥ 3 acute oral mucositis in oropharyngeal cancer patients treated with volumetric modulated arc radiotherapy.MethodsThis prospective study was done in 52 patients of locally advanced oropharyngeal cancer treated with Volumetric modulated arc radiotherapy. Dose-volume histogram data were extracted and then acute oral mucosa toxicity was analysed. Receiver operating characteristic analysis and logistic regression were carried out to determine predictive factors for grade ≥ 3 mucositis.ResultsGrade ≥ 3 acute oral mucositis occurred in 57.6% (30/52) patients in the study. V30Gy &gt; 53.35% (P = 0.005) was an independent dosimetric factor related to grade ≥ 3 acute toxicity. In the receiver operating characteristic curve, the area under V30Gy was 0.770 (P = 0.001); the cut-off value of V30 was 46.23% (sensitivity, 0.80; specificity, 0.91).ConclusionsDose-volume histogram analysis predicts V30 &gt; 53.35% as independent factors for grade ≥ 3 acute oral mucositis in patients with oropharyngeal cancers treated with Volumetric modulated arc radiotherapy. Studies in future with more patient number can further validate the above results.
Study of the inclusion complexes formed between 4-phenylbutyrate and α-, β- and γ-cyclodextrin in solution and evaluation on their taste-masking properties
Authors: Commey Kindness , Nakatake Akari , Enaka Airi , Nishi Koji , Tsukigawa Kenji , Yamaguchi Koki , Ikeda Hirohito , Iohara Daisuke , Hirayama Fumitoshi , Otagiri Masaki , Yamasaki Keishi 
Published: December 2022

Abstract

Objectives
4-Phenylbutyrate (PB), which is used in the management of urea cycle disorders, has an unpleasant taste leading to poor patient compliance. Existing PB formulations though helpful, have some limitations in their use. This study reports on attempts to mask this unpleasant taste by complexing PB with cyclodextrins (CDs) to improve patient compliance.

Methods
α, β and γCD were used as CDs. Phase solubility studies, circular dichroism, 1H-NMR spectroscopy, including ROESY, and molecular modelling were used to investigate and characterize the PB–CD interactions in solution. The taste-masking effect of the CDs was evaluated using in vitro taste sensor measurements.

Key findings
PB interacts with α, β and γCD in solution to form 1:1, 1:1 and 1:2 CD: PB inclusion complexes, respectively, with stability constants in the order αCD &gt; βCD &gt; γCD. Taste evaluation revealed that the CDs significantly mask the taste of PB through the formation of the inclusion complexes. Notably, αCD masked the bitter taste of PB to 30% of the initial taste at a 1:1 molar ratio.

Conclusion
αCD significantly masks the unpleasant taste of PB in solution and can be used to formulate PB to address the limitations of existing formulations and improve patient compliance and quality of life.
Two MYB activators of anthocyanin biosynthesis exhibit specialized activities in petiole and fruit of diploid strawberry
Authors: Luo Xi , Plunkert Madison , Teng Zi , Mackenzie Kathryn , Guo Lei , Luo Yaguang , Hytönen Timo , Liu Zhongchi 
Published: December 2022

AbstractThe R2R3-MYB transcription factor FveMYB10 is a major regulator of anthocyanin pigmentation in the red fruits of strawberry. fvemyb10 loss-of-function mutants form yellow fruits but still accumulate purple-colored anthocyanins in the petioles, suggesting that anthocyanin biosynthesis is under distinct regulation in fruits and petioles. From chemical mutagenesis in the diploid wild strawberry Fragaria vesca, we identified a green petioles (gp)-1 mutant that lacks anthocyanins in petioles. Using mapping-by-sequencing and transient functional assays, we confirmed that the causative mutation resides in a FveMYB10-Like (FveMYB10L) gene and that FveMYB10 and FveMYB10L function independently in the fruit and petiole, respectively. In addition to their tissue-specific regulation, FveMYB10 and FveMYB10L respond differently to changes in light quality, produce distinct anthocyanin compositions, and preferentially activate different downstream anthocyanin biosynthesis genes in their respective tissues. This work identifies a new regulator of anthocyanin synthesis and demonstrates that two paralogous MYB genes with specialized functions enable tissue-specific regulation of anthocyanin biosynthesis in fruit and petiole tissues.
Fine-tuned nitric oxide and hormone interface in plant root development and regeneration
Authors: Sanchez-Corrionero Alvaro , Sánchez-Vicente Inmaculada , Arteaga Noelia , Manrique-Gil Isabel , Gómez-Jiménez Sara , Torres-Quezada Isabel , Albertos Pablo , Lorenzo Oscar 
Published: December 2022

Abstract
Plant root growth and developmental capacities reside in a few stem cells of the root apical meristem (RAM). Maintenance of these stem cells requires regenerative divisions of the initial stem cell niche (SCN) cells, self-maintenance, and proliferative divisions of the daughter cells. This ensures sufficient cell diversity to guarantee the development of complex root tissues in the plant. Damage in the root during growth involves the formation of a new post-embryonic root, a process known as regeneration. Post-embryonic root development and organogenesis processes include primary root development and SCN maintenance, plant regeneration, and the development of adventitious and lateral roots. These developmental processes require a fine-tuned balance between cell proliferation and maintenance. An important regulator during root development and regeneration is the gasotransmitter nitric oxide (NO). In this review we have sought to compile how NO regulates cell rate proliferation, cell differentiation, and quiescence of SCNs, usually through interaction with phytohormones, or other molecular mechanisms involved in cellular redox homeostasis. NO exerts a role on molecular components of the auxin and cytokinin signaling pathways in primary roots that affects cell proliferation and maintenance of the RAM. During root regeneration, a peak of auxin and cytokinin triggers specific molecular programs. Moreover, NO participates in adventitious root formation through its interaction with players of the brassinosteroid and cytokinin signaling cascade. Lately, NO has been implicated in root regeneration under hypoxia conditions by regulating stem cell specification through phytoglobins.
The Library and Commonplace Books of Mary Booth of Dunham Massey (1704–1772)
Authors: Potten Edward 
Published: December 2022

Abstract
This paper offers a detailed case study of Mary Booth as book owner and book user using two primary sources: her surviving library and her commonplace books. Booth’s fastidious approach to marking her books, coupled with the fortunate survival of the two houses where those books ultimately came to rest, allows for the reconstruction of her library almost in its entirety. Her commonplace books present an unusually rich record of her reading. Together, these sources offer a rare insight into the life, education, and book use of an early eighteenth-century gentlewoman, a rare comparator against which other women’s collections and habits of reading can be assessed.
Origins of B-type stars at high Galactic latitudes based on abundances and kinematics
Authors: Liu Zhicun , Cui Wenyuan , Zhao Gang , Liu Chao , Luo Changqing , Alexeeva Sofya 
Published: December 2022

ABSTRACT
The spectral analysis and kinematic studies of faint blue stars of O and B types above the mid-plane of the Milky Way can lead to a better understanding of their populations and origins. In this paper, we present an analysis of the chemical composition and kinematics of 17 B-type stars. Our sample includes 13 B-type stars with |Z| &gt; 0.5 kpc and |b| ≥ 20°, three B-type stars with |Z| ≤ 0.5 kpc and |b| &lt; 20°, and a hot post-asymptotic giant branch (post-AGB) star without infrared excess, in the Milky Way. Our analysis rests on medium-resolution spectra and non-local thermodynamic equilibrium tlusty model atmospheres. The ages and masses of the stars are obtained using solar-metallicity PARSEC isochrones, and we calculate their velocities and Galactic trajectories using galpy and data from the Gaia EDR3. The larger projected rotational velocities and results of abundance analysis of 16 B-type stars indicate that they are likely to be B-type stars of normal Population I. The three B-type stars with |Z| ≤ 0.5 kpc and |b| &lt; 20° can be formed in the Galactic disc. The origins of the 13 B-type stars with |Z| &gt; 0.5 kpc and |b| ≥ 20° are as follows. (i) Analysis of the C and Mg abundances, kinematics and orbits show that 10 of them originate in the Galactic disc at different Galactocentric distances. They may be scattered from the disc via the binary ejection mechanism or the dynamical ejection mechanism. (ii) The three stars presenting abnormal C or Mg abundances and counter-rotating Vϕ might be post-AGB stars accreted from a disrupted satellite of the Milky Way.