bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoscale Management of CO Transport in CO2 Electroreduction: Boosting Faradaic Efficiency to Multicarbon Products via Nanostructured Tandem Electrocatalysts
Authors: Wei Chaolong , Yang Yuehua , Ma Haibin , Sun Guangxin , Wang Xin , Cheng Yaqi , Zhang Caiwei , Yeo Boon Siang , He Chunnian , Wong Andrew Barnabas 
Published: April 2023

AbstractTandem catalysis presents a promising strategy to improve the selectivity toward multicarbon products in the electrocatalytic carbon dioxide reduction reaction (CO2RR). For CO2RR, CO is a critical intermediate for producing multicarbon products. However, the management of CO localization and CO diffusion remains underexplored despite its critical role. Herein, a 3D tandem catalyst electrode with silver nanoparticles (Ag NPs) is designed to generate CO as an intermediate product within a copper (Cu) nanoneedle array. Via this nanostructured design, CO2 forms C2+ products with a high Faradaic efficiency (FEC2+) of 64% in an H‐cell and 70% in a flow cell with a current density of 350 mA cm−2. These figures‐of‐merit are currently among the top literature reports. More importantly, in situ Raman spectroscopy and finite‐element method calculations are employed to elucidate the origins of enhanced selectivity. These approaches reveal the crucial role of prolonging the CO diffusion path length for improving CO utilization during CO2 conversion with tandem catalyst systems. The favorable CO2RR FEC2+ in two distinct environments (H‐cell and flow cell) further corroborates that this effect is not limited to a particular reactor environment. Overall, this study provides new insights for designing tandem catalysts for improved CO2RR selectivity to C2+ products.
Solidly Mounted Resonators with Ultra‐High Operating Frequencies Based on 3R‐MoS2 Atomic Flakes
Authors: Yang Yang , Sun Jiayi , Cai Weifan , Liu Zheng , Dejous Corinne , De Matos Magali , Hallil Hamida , Zhang Qing 
Published: April 2023

AbstractConventional bulk and thin piezoelectric materials based film bulk acoustic resonators (FBARs) are facing an insurmountable challenge for millimetric frequency applications due to the poor piezoelectric properties of the materials when their thickness reaches the sub‐micron regime. Novel FBARs for ultra‐high working frequencies are in urgent demand to meet the requirements of the fast‐growing 5/6G telecommunication techniques. Recent advances in 2D piezoelectric nanomaterials create an opportunity in this perspective. Here, the first FBAR chip based on 2D 3R‐MoS2 ultrathin piezoelectric flakes with a solidly mounted resonator (SMR) architecture is reported. The typical resonant frequency for an SMR device based on ≈200 nm 3R‐MoS2 flake reaches over 25 GHz with high reproducibility. Theoretical and finite element analysis suggest that the observed resonance is of longitudinal acoustic modes. This study demonstrates for the first time that the access to 2D piezoelectric nanomaterials makes high performance piezoelectric devices feasible for various promising applications including high‐speed telecommunication, acousto‐optic, and sensor fields,etc.
Voltage Hysteresis in Transition Metal Oxide Cathodes for Li/Na‐Ion Batteries
Authors: Li Fei , Liu Renbin , Liu Jie , Li Hongsen 
Published: April 2023

AbstractThe pursuit of rechargeable batteries with high energy density has triggered enormous efforts in developing cathode materials for lithium/sodium (Li/Na)‐ion batteries considering their extremely high specific capacity. Many materials are being researched for battery applications, and transition metal oxide materials with remarkable electrochemical performance stand out among numerous cathode candidates for next‐generation battery. Notwithstanding the merits, daunting challenges persist in the quest for further battery developments targeting lower cost, longer lifespan, improved energy density and enhanced safety. This is, in part, because the voltage hysteresis between the charge and discharge cycles, is historically avoided in intercalation electrodes because of its association with structural disorder and electrochemical irreversibility. Given the great potential of these materials for next‐generation batteries, a review of the recent understanding of voltage hysteresis is timely. This review presents the origin of their undesirable behaviors and materials design criteria to mitigate them by integrating various schools of thought. A large amount of progressive characterization techniques related to voltage hysteresis are summarized from the literature, along with the corresponding measurable range used in their determination. Finally, promising design trends with eliminated voltage hysteresis are tentatively proposed to revive these important cathode materials toward practical applications.
Surface Defect Suppression for High Color Purity Light‐Emitting Diode of Free‐Standing Single‐Crystal Perovskite Film
Authors: Li Lutao , Hu Yun , Chen Yuan , Wang Chen , Zhao Guoxiang , Du Xinyu , Wang Chaoqiang , Xiao Lingbo , Lu Zheng , Wang Jiong , Wang Dan , Jie Jiansheng , Huang Jingsong , Zou Guifu 
Published: April 2023

AbstractHigh color purity is one of the important features for single‐crystal metal halide perovskite light‐emitting diode (LED). Despite single‐crystal perovskite showing low bulk defect concentration, single‐crystal perovskite LEDs do not exhibit high color purity advantage due to the absence of effective surface defect passivation. Herein, one fully wrapped structure is proposed to passivate the surface of the free‐standing CsPbBr3 single‐crystal films. The surface of CsPbBr3 single‐crystal films is wrapped by ultra‐thin polymethyl methacrylate, precisely controlling the thickness. The single‐crystal perovskite film device can achieve high color purity with a full width at half maximum (FWHM) of 15.8 nm) and a large luminescent area of 2.25 mm2. It is observed that surface passivation is due to interaction of CO bond in polymer chains with the Lewis acid PbBr2. The passivated perovskite single‐crystal films significantly improve carrier lifetime and suppress surface defects. It is noteworthy that the passivated free‐standing single‐crystal perovskite films are feasible to build up a vertical LED device structure, avoiding the edge glowing and short‐circuiting of the LED device. This study demonstrates the large luminescent area of the high‐quality millimetre‐scale free‐standing single‐crystal films for wide color gamut display and vertical optoelectronic devices.
Chiral Metallopolymers for Redox‐Mediated Enantioselective Interactions
Authors: Jeon Jemin , Elbert Johannes , Chung Ching‐Hsiu , Chae Junice , Su Xiao 
Published: April 2023

AbstractSynthetic chiral platforms can be a powerful platform for enantioselective interactions, especially when coupled with redox‐mediated electrochemical processes. While metallopolymers are versatile platforms for molecularly selective binding, their application for chiral applications is limited. In particular, the recognition and separation of biologically relevant chiral molecules can be key for biomanufacturing and diagnostics. Here, the design of chiral redox‐polymers enables electrochemically‐controlled enantioselective interactions, and supramolecular chirality is leveraged for enhancing recognition towards target enantiomers. Chiral redox‐metallopolymers are synthesized based on Ugi's amine‐inspired chiral monomers, and their enantioselective recognition toward ionic enantiomers such as tryptophan and naproxen is demonstrated, with higher enanhcement provided by the chiral redox‐polymer over the single‐site, chiral building bloack itelf. 2D nuclear magnetic resonance spectroscopy and solid‐state circular dichroism support the emergence of supramolecular chirality resulting from the intramolecular interaction between the ferrocene and the alkyl group in the backbone. The half potential shift of the redox‐polymers behaves linearly from 0% to 100%ee l‐tryptophan to enable enantiomer quantification. Investigation on solvent polarity and pH effect reveal that the enantioselective mechanism is attributed to the subtle balance between hydrogen bonding and π–π interaction. This study highlights the potential of chiral redox‐metallopolymers as platforms for electrochemically‐modulated enantioselective interactions towards a range of amino acids and pharmaceutical carboxylates.
Nanocellulose‐Carboxymethylcellulose Electrolyte for Stable, High‐Rate Zinc‐Ion Batteries
Authors: Xu Lin , Meng Taotao , Zheng Xueying , Li Tangyuan , Brozena Alexandra H. , Mao Yimin , Zhang Qian , Clifford Bryson Callie , Rao Jiancun , Hu Liangbing 
Published: April 2023

AbstractAqueous Zn ion batteries (ZIBs) are one of the most promising battery chemistries for grid‐scale renewable energy storage. However, their application is limited by issues such as Zn dendrite formation and undesirable side reactions that can occur in the presence of excess free water molecules and ions. In this study, a nanocellulose‐carboxymethylcellulose (CMC) hydrogel electrolyte is demonstrated that features stable cycling performance and high Zn2+conductivity (26 mS cm−1), which is attributed to the material's strong mechanical strength (≈70 MPa) and water‐bonding ability. With this electrolyte, the Zn‐metal anode shows exceptional cycling stability at an ultra‐high rate, with the ability to sustain a current density as high as 80 mA cm−2for more than 3500 cycles and a cumulative capacity of 17.6 Ah cm−2(40 mA cm−2). Additionally, side reactions, such as hydrogen evolution and surface passivation, are substantially reduced due to the strong water‐bonding capacity of the CMC. Full Zn||MnO2batteries fabricated with this electrolyte demonstrate excellent high‐rate performance and long‐term cycling stability (>500 cycles at 8C). These results suggest the cellulose‐CMC electrolyte as a promising low‐cost, easy‐to‐fabricate, and sustainable aqueous‐based electrolyte for ZIBs with excellent electrochemical performance that can help pave the way toward grid‐scale energy storage for renewable energy sources.
A Liquid Metal Microdroplets Initialized Hemicellulose Composite for 3D Printing Anode Host in Zn‐Ion Battery
Authors: Shi Ge , Peng Xinwen , Zeng Jiaming , Zhong Linxin , Sun Yuan , Yang Wu , Zhong Yu Lin , Zhu Yuxuan , Zou Ren , Admassie Shimelis , Liu Zhaoqing , Liu Chuanfu , Iwuoha Emmanuel I. , Lu Jun 
Published: April 2023

AbstractMaintaining a steady affinity between gallium‐based liquid metals (LM) and polymer binders, particularly under continuous mechanical deformation, such as extrusion‐based 3D printing or plating/stripping of Zinc ion (Zn2+), is very challenging. Here, an LM‐initialized polyacrylamide‐hemicellulose/EGaIn microdroplets hydrogel is used as a multifunctional ink to 3D‐print self‐standing scaffolds and anode hosts for Zn‐ion batteries. The LM microdroplets initiate acrylamide polymerization without additional initiators and cross‐linkers, forming a double‐covalent hydrogen‐bonded network. The hydrogel acts as a framework for stress dissipation, enabling recovery from structural damage due to the cyclic plating/stripping of Zn2+. The LM‐microdroplet‐initialized polymerization with hemicelluloses can facilitate the production of 3D printable inks for energy storage devices.
A Hierarchical Hybrid MXenes Interlayer with Triple Function for Room‐Temperature Sodium‐Sulfur Batteries
Authors: Huang Zefu , Wang Shijian , Guo Xin , Safaei Javad , Lei Yaojie , Lai Wei‐Hong , Zhang Xiuyun , Sun Bing , Shanmukaraj Devaraj , Armand Michel , Rojo Teofilo , Wang Guoxiu 
Published: April 2023

AbstractRoom temperature sodium sulfur (RT Na‐S) batteries with high theoretical energy density and low cost have recently gained extensive attention for potential large‐scale energy storage applications. However, the shuttle effect of sodium polysulfides is still the main challenge that leads to poor cycling stability, which hinders the practical application of RT Na‐S batteries. Herein, a multifunctional hybrid MXene interlayer is designed to stabilize the cycling performance of RT Na‐S batteries. The hybrid MXene interlayer comprises a large‐sized Ti3C2Tx nanosheets inner layer followed by a small‐sized Mo2Ti2C3Tx nanoflake outer layer on the surface of the glass fiber (GF) separator. The large‐sized Ti3C2Tx nanosheet inner layer provides an effective physical block and chemical confinement for the soluble polysulfides. The small‐sized Mo2Ti2C3Tx outer layer offers an excellent polysulfide trapping capability and accelerates the reaction kinetics of polysulfide conversion, due to its superior electronic conductivity, large specific surface area, and Mo‐rich catalytic surfaces. As a result, RT Na‐S batteries with this hybrid MXene interlayer modified glass fiber separator deliver a stable cycling performance over 200 cycles at 1 C with an enhanced capacity retention of 71%. This unique structure design provides a novel strategy to develop 2D material‐based functional interlayer for high‐performance metal‐sulfur batteries.
Towards stable wheat grain yield and quality under climatic instability
Authors: Bonfil David J. , Abbo Shahal , Degen Doron , Simchon Yasmin , Ben‐David Roi 
Published: April 2023

AbstractGlobal wheat production is likely to be affected by projected warming and water scarcity. As climate changes faster than breeding, we focused on genotypic and environmental effects on grain production and quality of present wheat cultivars. To mimic the continuous challenges farmers face given the erratic rainy seasonal and temperature pattern of the Eastern Mediterranean, 15 commercial hard spring wheat (HSW) cultivars were evaluated at Gilat Research Center, Israel, over four seasons constituting 33 independent dryland field environments. Grains of HSW samples from commercial and experimental nurseries across Israel over three seasons were also analyzed to represent the Eastern Mediterranean wheat agroclimatic span. Samples were analyzed for grain yield and quality traits. High humidity and mild temperature during grain filling were associated with higher production, flour extraction, and dough extensibility; whereas high precipitation was mainly associated with lower protein, lower gluten content, and dough tenacity. Correlation between grain protein content and wet gluten was affected by environment and is cultivar dependent, as precipitation during a specific phase plays a major factor for some cultivars, while others are affected more by temperature, humidity, or other factors. Test weight and gluten index showed the clearest relation between performance and variation, enabling to identify cultivar stability across environments. Stable cultivars are more acceptable in the market, however, if a specific quality parameter is highly important for the millers and/or the bakers then the stability of this parameter under multiple growth conditions might serve as a decision support tool for on‐farm commercial cultivar selection.
A review of metal nanoparticle‐based surface‐enhanced Raman scattering substrates for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) detection
Authors: Abu Bakar Norhayati , Yusoff Nur Nazhifah , Nor Azmi Farah Shahadah , Shapter Joseph George 
Published: April 2023

AbstractMonitoring an infectious disease early using highly sensitive and non‐invasive techniques is critical for human health. Interestingly, the development of surface‐enhanced Raman scattering (SERS) for biological detection ideally fits these medical requirements and is rapidly growing as a powerful diagnostic tool. SERS can enhance the Raman signal of the target molecule by more than 106 after the adsorption of the molecule on the plasmonic nanostructured surface. This review provides an overview of the use of gold and silver nanoparticles in SERS substrate designs, followed by the development of these SERS substrates in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) detection.
Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer
Authors: Guo Yan , Cui Yuqing , Li Yangyang , Jin Xiaoying , Wang Dandan , Lei Mengxia , Chen Fengzhi , Liu Yali , Xu Jinwen , Yao Guanyu , Zeng Guangchun , Chen Xuesong 
Published: April 2023

AbstractBackgroundNuclear Yes1‐associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear. Our research aimed to explore the biological function of cytoplasmic YAP1 in breast cancer cells and the possibility of cytoplasmic YAP1 as a predictive marker of breast cancer survival.MethodsWe constructed cell mutant models, including NLS‐YAP15SA (nuclear localized), YAP1S94A (incapable of binding to the TEA domain transcription factor family) and YAP1S127D (cytoplasmic localized), and used Cell Counting Kit‐8 (CCK‐8) assays, 5‐ethynyl‐2’‐deoxyuridine (EdU) incorporation assays, and Western blotting (WB) analysis to detect cell proliferation and apoptosis. The specific mechanism of cytoplasmic YAP1‐mediated endosomal sorting complexes required for transport III (ESCRT‐III) assembly was studied by co‐immunoprecipitation, immunofluorescence staining, and WB analysis. Epigallocatechin gallate (EGCG) was used to simulate YAP1 retention in the cytoplasm in in vitro and in vivo experiments to study the function of cytoplasmic YAP1. YAP1 binding to NEDD4‐like E3 ubiquitin protein ligase (NEDD4L) was identified using mass spectrometry and was verified in vitro. Breast tissue microarrays were used to analyze the relationship between cytoplasmic YAP1 expression and the survival of breast cancer patients.ResultsYAP1 was mainly expressed in the cytoplasm in breast cancer cells. Cytoplasmic YAP1 promoted autophagic death of breast cancer cells. Cytoplasmic YAP1 bound to the ESCRT‐III complex subunits charged multivesicular body protein 2B (CHMP2B) and vacuolar protein sorting 4 homolog B (VPS4B), promoting assembly of CHMP2B‐VPS4B and activating autophagosome formation. EGCG retained YAP1 in the cytoplasm, promoting the assembly of CHMP2B‐VPS4B to promote autophagic death of breast cancer cells. YAP1 bound to NEDD4L, and NEDD4L mediated ubiquitination and degradation of YAP1. Breast tissue microarrays revealed that high levels of cytoplasmic YAP1 were beneficial to the survival of breast cancer patients.ConclusionsCytoplasmic YAP1 mediated autophagic death of breast cancer cells by promoting assembly of the ESCRT‐III complex; furthermore, we established a new breast cancer survival prediction model based on cytoplasmic YAP1 expression.
Amperometric Detection of Glucose Using a Bimetallic Polymeric Film on a Pencil Graphite Electrode
Authors: Jose Stephy , Das Sudev , C Beula , Vakamalla Teja Reddy , Sen Dipak 
Published: April 2023

AbstractA non‐enzymatic electrochemical sensor was to be developed for the detection of glucose by combining the features of a molecularly imprinted polymer, the high conductive nature of polyaniline, and hierarchical dendritic structures. To meet this aim, a bimetallic film‐coated graphite electrode was electropolymerized in the presence of aniline monomers to obtain a glucose‐imprinted bimetallic polymeric film‐coated electrode. The parameters affecting the electrodeposition were optimized using Minitab 19.1 software, and the mechanism of electrooxidation of glucose on the electrode surface was proposed. Electrochemical and morphological characterization of the fabricated electrode revealed its sensitivity toward millimolar amounts of glucose and showed higher selectivity in the presence of interfering species.
Praziquantel – 50 Years of Research
Authors: Waechtler Andreas , Cezanne Bertram , Maillard David , Sun Rui , Wang Shaofang , Wang Jihua , Harder Achim 
Published: April 2023

AbstractInvestigations on praziquantel (PZQ) started fifty years ago by a cooperation between Bayer AG and Merck KGaA. Until today PZQ is the drug of choice for schistosomiasis in human medicine and used in many combinations with antinematode drugs in veterinary medicine. The Sm.TRPMPZQ, a Ca2+ ‐permeable transient receptor potential (TRP) channel, has been discovered as primary target of PZQ during the last decade. Furthermore, there is a short overview of routes of large‐scale synthesis of racemic and pure (R)‐PZQ. Until now racemic PZQ is used in veterinary and human medicine. In 2012 the Pediatric Praziquantel Consortium started PZQ chemistry and process development of pure (R)‐PZQ for human application. It is hoped that (R)‐PZQ will become available for pediatric use soon. The knowledge of the binding pocket of PZQ in Sm.TRPMPZQ allows to design synthesis of PZQ‐derivatives of the next generation for a target‐site directed screening. A similar screening should also be started for Fasciola hepatica TRPMPZQ.
How social media can help to understand treatment experiences of survivors of rare cancers: Findings from the Granulosa Cell Tumor Survivor Sisters Facebook group member survey
Authors: White Victoria M. , Alexiadis Maria , Eroh Kimberly D. , Ackermann M. Kaye , Rodgers Sue , Langdale Linda M. , Armour Natasha E. , Jobling Thomas W. , Fuller Peter J. , Chu Simon 
Published: April 2023

AbstractBackgroundEngaging with online social media consumer groups for rare cancers may help to develop collaborations between consumers and researchers. This study, a collaboration with the Granulosa Cell Tumor‐Survivor Sisters (GCT‐SS) Facebook group, explores the results of their survey of member's treatment and follow‐up experiences.MethodsMembers of the closed multinational GCT‐SS Facebook group completed a 43‐item survey covering symptoms, diagnosis, treatment, recurrence, follow‐up, and possible risk factors for GCT. Group members could have adult (aGCT) or juvenile (jGCT) disease. Data was collected via an online survey between 2014 and 2019.ResultsA total of 743 members (average 4.4 years [SD = 5.9] post‐diagnosis) participated including 52 with jGCT. A total of 67% had stage I disease and 8% had stage III–IV at diagnosis, although 30% of aGCT and 25% of jGCT reported recurrent disease at survey completion. A total of 48% of aGCT had laparoscopic surgery, tumor encapsulation was reported by 49%, and tumor bagging reported by 29% overall (37% laparoscopic; 8% open). Recurrence rates were higher when the tumor was cut or ruptured (ruptured: p < .001; cut: p = .01). A total of 19% of aGCT had chemotherapy with this most common for stage II‐III disease. Bleomycin, etoposide, and cisplatin protocols became less common over time (diagnosed before 2015: 47% vs. diagnosed post‐2015: 21%).ConclusionsThis is one of the largest surveys of GCT treatment. Members of the GCT‐SS group report treatment patterns generally in line with those found from clinical audits. Using naturally forming consumer groups may assist with developing the evidence base for care and supporting those living with GCT ovarian cancer.Plain language summary

This study is a collaboration between members of Granulosa Cell Tumor‐Survivor Sisters (GCT‐SS) Facebook group and researchers to assess members' experiences of treatment and follow‐up.

A total of 743 members (52 with juvenile GCT) completed an online survey.

A total of 67% had stage I disease at diagnosis.

Treatment patterns were generally in line with those found from clinical audits: 95% had surgery and 19% of those with adult GCT had chemotherapy.

A total of 30% reported recurrent disease, with recurrence occurring within 5 years of diagnosis for 33%.

Using naturally forming consumer groups may assist with developing the evidence base for care and supporting those living with GCT ovarian cancer.