bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Warning for the Electrolyzer: Monitoring CO2 Reduction via In‐Line Electrochemical Impedance Spectroscopy
Authors: Warkentin Hugh , O'Brien Colin P. , Holowka Sarah , Maxwell Benjamin , Awara Mariam , Bouman Mark , Zeraati Ali Shayesteh , Nicholas Rachael , Ip Alexander H. , Elsahwi Essam S. , Gabardo Christine M. , Sinton David 
Published: August 2023

AbstractThe electrochemical CO2 reduction reaction (CO2RR) to fuels and feedstocks presents an opportunity to decarbonize the chemical industry, and current electrolyzer performance levels approach commercial viability. However, stability remains below that required, in part because of the challenge of probing these electrolyzer systems in real time and the challenge of determining the root cause of failure. Failure can result from initial conditions (e. g., the over‐ or under‐compression of the electrolyzer), gradual degradation of components (e. g., cathode or anode catalysts), the accumulation of products or by‐products, or immediate changes such as the development of a hole in the membrane or a short circuit. Identifying and mitigating these assembly‐related, gradual, and immediate failure modes would increase both electrolyzer lifetime and economic viability of CO2RR. We demonstrate the continuous monitoring of CO2RR electrolyzers during operation via non‐disruptive, real‐time electrochemical impedance spectroscopy (EIS) analysis. Using this technique, we characterise common failure modes ‐ compression, salt formation, and membrane short circuits ‐ and identify electrochemical parameter signatures for each. We further propose a framework to identify, predict, and prevent failures in CO2RR electrolyzers. This framework allowed for the prediction of anode degradation ~11 hours before other indicators such as selectivity or voltage.
Design, synthesis, and biological evaluation of novel pleuromutilin derivatives containing benzimidazoles as effective anti‐MRSA agents
Authors: Zhang Qi‐Wen , Ren Jie , Lu Jia‐Xun , Chen Xiao‐Ying , He Xian‐Jin , Wang Qi , Zhou Zi‐Dan , Jin Zhen , Zeng Zhen‐Ling , Tang You‐Zhi 
Published: August 2023

AbstractA series of pleuromutilin derivatives containing benzimidazole were designed, synthesized, and evaluated for their antibacterial activities against Methicillin‐resistant Staphylococcus aureus (MRSA) in this study. The in vitro antibacterial activities of the synthesized derivatives against four strains of S. aureus (MRSA ATCC 43300, S. aureus ATCC 29213, S. aureus 144, and S. aureus AD3) were determined by the broth dilution method. Among these derivatives, compound 58 exhibited superior in vitro antibacterial effect against MRSA (minimal inhibitory concentration [MIC] = 0.0625 μg/mL) than tiamulin (MIC = 0.5 μg/mL). Compound 58 possessed a faster bactericidal kinetic and a longer post‐antibiotic effect time against MRSA than tiamulin. Meanwhile, at 8 μg/mL concentration, compound 58 did not display obviously cytotoxic effect on the RAW 264.7 cells. In addition, compound 58 (−2.04 log10 CFU/mL) displayed superior in vivo antibacterial efficacy than tiamulin (−1.02 log10 CFU/mL) in reducing MRSA load in mice thigh infection model. In molecular docking study, compound 58 can successfully attach to the 50S ribosomal active site (the binding free energy is −8.11 kcal/mol). Therefore, compound 58 was a potential antibacterial candidate for combating MRSA infections.
Patient mortality following new‐onset heart failure stratified by cancer type and status
Authors: Nouhravesh Nina , Strange Jarl E. , Holt Anders , Tønnesen Jacob , Andersen Camilla Fuchs , Nielsen Sebastian K. , Køber Lars , Mentz Robert J. , Nielsen Dorte , Fosbøl Emil L. , Lamberts Morten , Schou Morten 
Published: August 2023

ABSTRACTAimExpected 1‐year survival is essential to risk stratification of patients with heart failure (HF); however, little is known about the 1‐year prognosis of patients with HF and cancer. Thus, the objective was to investigate the 1‐year prognosis following new‐onset HF stratified by cancer status in patients with breast, gastrointestinal, or lung cancer.Methods and resultsAll Danish patients with new‐onset HF from 2000 to 2018 were included. Cancer status was categorized as history of cancer (no cancer‐related contact within 5 years of HF diagnosis), non‐active cancer (curative intended procedure administered) and active cancer. Standardized 1‐year all‐cause mortality was reported using G‐computation. Age‐stratified 1‐year all‐cause mortality was estimated using the Kaplan–Meier estimator. In total, 193 359 patients with HF were included, 7.3% had either a breast, gastrointestinal, or lung cancer diagnosis. Patients with cancer were older and more comorbid than patients without cancer. Standardized 1‐year all‐cause mortality (95% confidence intervals) was 24.6% (23.0–26.2%), 27.1% (25.5–28.6%), and 29.9% (25.9–34.0%) for history of breast, gastrointestinal and lung cancer, respectively, which was comparable to patients with non‐active cancers. For active breast, gastrointestinal and lung cancer, standardized 1‐year all‐cause mortality was 36.2% (33.8–38.6%), 49.0% (47.2–50.9%), and 61.6% (59.7–63.5%), respectively. One‐year all‐cause mortality increased incrementally with age, except for active lung cancer.ConclusionStandardized 1‐year all‐cause mortality was comparable for patients with history of cancer and non‐active cancer regardless of cancer type, but varied comprehensively for active cancers. Prognostic impact of age was limited for active lung cancer. Thus, granular stratification of cancer is necessary for optimized management of new‐onset HF.
Transfer‐entropy‐based dynamic feature selection for evaluating Bitcoin price drivers
Authors: Barak Sasan , Parvini Navid 
Published: August 2023

AbstractDespite the growing literature in cryptocurrency forecasting and their price drivers, the relationship between their price and other financial time series is an ongoing matter of debate. This study proposes a three‐step methodology to cover these arguments. First, we conduct an ad hoc analysis using transfer entropy (TE) to study the causal relationship between Bitcoin (BTC) returns and a vast array of financial time series. Then, we utilize variables with a significant amount of information flow toward BTC returns to forecast multi‐step‐ahead BTC returns. Finally, we use explainable artificial intelligence post hoc analysis methods to discover the contribution of each input feature to the overall forecasting. The results indicate a significant change in the information flow pattern in the first days of the COVID‐19 pandemic outbreak. Additionally, our proposed TE‐based feature‐selection method outperforms both benchmarks, a nonfeature‐selection model, and backward stepwise regression.
Nanoplatforms: The future of oral cancer treatment
Authors: Senevirathna Kalpani , Jayawickrama Shalindu M. , Jayasinghe Yovanthi A. , Prabani Karunakalage I. P. , Akshala Kushani , Pradeep Ratupaskatiye G. G. R. , Damayanthi Hewaratne D. W. T. , Hettiarachchi Kalani , Dorji Thinley , Lucero‐Prisno Don E. , Rajapakse Rajapakse M. G. , Kanmodi Kehinde K. , Jayasinghe Ruwan D. 
Published: August 2023

AbstractBackground and AimsCytotoxicity is a key disadvantage of using chemotherapeutic drugs to treat cancer. This can be overcome by encapsulating chemotherapeutic drugs in suitable carriers for targeted delivery, allowing them to be released only at the cancerous sites. Herein, we aim to review the recent scientific developments in the utilization of nanotechnology‐based drug delivery systems for treating oral malignancies that can lead to further improvements in clinical practice.MethodsA comprehensive literature search was conducted on PubMed, Google Scholar, ScienceDirect, and other notable databases to identify recent peer‐reviewed clinical trials, reviews, and research articles related to nanoplatforms and their applications in oral cancer treatment.ResultsNanoplatforms offer a revolutionary strategy to overcome the challenges associated with conventional oral cancer treatments, such as poor drug solubility, non‐specific targeting, and systemic toxicity. These nanoscale drug delivery systems encompass various formulations, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, which facilitate controlled release and targeted delivery of therapeutic agents to oral cancer sites. By exploiting the enhanced permeability and retention effect, Nanoplatforms accumulate preferentially in the tumor microenvironment, increasing drug concentration and minimizing damage to healthy tissues. Additionally, nanoplatforms can be engineered to carry multiple drugs or a combination of drugs and diagnostic agents, enabling personalized and precise treatment approaches.ConclusionThe utilization of nanoplatforms in oral cancer treatment holds significant promise in revolutionizing therapeutic strategies. Despite the promising results in preclinical studies, further research is required to evaluate the safety, efficacy, and long‐term effects of nanoformulations in clinical settings. If successfully translated into clinical practice, nanoplatform‐based therapies have the potential to improve patient outcomes, reduce side effects, and pave the way for more personalized and effective oral cancer treatments.
Maximally edge‐connected realizations and Kundu's k $k$‐factor theorem
Authors: Shook James M. 
Published: August 2023

AbstractA simple graph with edge‐connectivity and minimum degree is maximally edge‐connected if . In 1964, given a nonincreasing degree sequence , Jack Edmonds showed that there is a realization of that is ‐edge‐connected if and only if with when . We strengthen Edmonds's result by showing that given a realization of if is a spanning subgraph of with such that when , then there is a maximally edge‐connected realization of with as a subgraph. Our theorem tells us that there is a maximally edge‐connected realization of that differs from by at most edges. For , if has a spanning forest with components, then our theorem says there is a maximally edge‐connected realization that differs from by at most edges. As an application we combine our work with Kundu's ‐factor theorem to show there is a maximally edge‐connected realization with a ‐factor for and present a partial result to a conjecture that strengthens the regular case of Kundu's ‐factor theorem.
The use of radiomics in magnetic resonance imaging for the pre‐treatment characterisation of breast cancers: A scoping review
Authors: Campana Annalise , Gandomkar Ziba , Giannotti Nicola , Reed Warren 
Published: August 2023

AbstractRadiomics is an emerging field that aims to extract and analyse a comprehensive set of quantitative features from medical images. This scoping review is focused on MRI‐based radiomic features for the molecular profiling of breast tumours and the implications of this work for predicting patient outcomes. A thorough systematic literature search and outcome extraction were performed to identify relevant studies published in MEDLINE/PubMed (National Centre for Biotechnology Information), EMBASE and Scopus from 2015 onwards. The following information was retrieved from each article: study purpose, study design, extracted radiomic features, machine learning technique(s), sample size/characteristics, statistical result(s) and implications on patient outcomes. Based on the study purpose, four key themes were identified in the included 63 studies: tumour subtype classification (n = 35), pathologically complete response (pCR) prediction (n = 15), lymph node metastasis (LNM) detection (n = 7) and recurrence rate prediction (n = 6). In all four themes, reported accuracies widely varied among the studies, for example, area under receiver characteristics curve (AUC) for detecting LNM ranged from 0.72 to 0.91 and the AUC for predicting pCR ranged from 0.71 to 0.99. In all four themes, combining radiomic features with clinical data improved the predictive models. Preliminary results of this study showed radiomics potential to characterise the whole tumour heterogeneity, with clear implications for individual‐targeted treatment. However, radiomics is still in the pre‐clinical phase, currently with an insufficient number of large multicentre studies and those existing studies are often limited by insufficient methodological transparency and standardised workflow. Consequently, the clinical translation of existing studies is currently limited.
Inequitable access to Ebola vaccines and the resurgence of Ebola in Africa: A state of arts review
Authors: Abdul‐Rahman Toufik , Lawal Lukman , Meale Emily , Ajetunmobi Oyinbolaji A. , Toluwalashe Soyemi , Alao Uthman Hassan , Ghosh Shankhaneel , Garg Neil , Aborode Abdullahi Tunde , Wireko Andrew Awuah , Mehta Aashna , Sikora Kateryna 
Published: August 2023

AbstractThe Ebola virus, a member of the filoviridae family of viruses, is responsible for causing Ebola Virus Disease (EVD) with a case fatality rate as high as 50%. The largest EVD outbreak was recorded in West Africa from March 2013 to June 2016, leading to over 28 000 cases and 11 000 deaths. It affected several countries, including Nigeria, Senegal, Guinea, Liberia, and Sierra Leone. Until then, EVD was predominantly reported in remote villages in central and west Africa close to tropical rainforests. Human mobility, behavioral and cultural norms, the use of bushmeat, burial customs, preference for traditional remedies and treatments, and resistance to health interventions are just a few of the social factors that considerably aid and amplify the risk of transmission. The scale and persistence of recent ebola outbreaks, as well as the risk of widespread global transmission and its ability for bioterrorism, have led to a rethinking of public health strategies to curb the disease, such as the expedition of Ebola vaccine production. However, as vaccine production lags in the subcontinent, among other challenges, the risk of another ebola outbreak is likely and feared by public health authorities in the region. This review describes the inequality of vaccine production in Africa and the resurgence of EVD, emphasizing the significance of health equality.
Collocating pipelines to minimize fragmentation: evaluating ecological costs of a shale gas mitigation practice
Authors: Langlois Lillie A. , Brenner Stephen J. , Brittingham Margaret C. 
Published: August 2023

AbstractShale gas development occurs in forests of the Appalachian Basin within breeding habitat for forest songbirds. Development requires linear infrastructure (e.g., pipelines, gas access roads) that fragments habitat and reduces core forest. Collocation is a mitigation practice that sites new pipelines adjacent to existing surface disturbance such as forest roads; it reduces core forest loss but may have associated ecological costs, defined as negative effects on native species and ecosystems. We conducted a paired sampling design between forest roads and collocated pipelines (expanded gas access roads collocated with pipelines) to evaluate ecological costs to forest songbirds in 2013 in Pennsylvania, USA. We surveyed 4 focal songbird species: 3 territorial species that varied in habitat requirements and the non‐territorial brown‐headed cowbird (Molothrus ater), an obligate brood parasite. We used spot mapping to survey focal species within linear corridors and the adjacent mature forest. Territory density of forest interior ovenbirds (Seiurus aurocapilla) was significantly lower on collocated pipelines (5.1 fewer territories per 10 ha) compared to forest road sites. We found no effect of collocation on territory density for the early successional species, eastern towhee (Pipilo erythrophthalmus) and chestnut‐sided warbler (Setophaga pensylvanica). Territories of all 3 territorial focal species crossed collocated pipeline sites less frequently than forest roads (ovenbird: 16%, eastern towhee: 14%, chestnut‐sided warbler: 31%) and the barrier effect increased with increasing corridor width. In contrast, brown‐headed cowbird abundance was 15 times greater at collocated pipelines compared to forest roads, suggesting that wider gas corridors provide enhanced access routes for cowbirds. Our study indicates the expansion of forest roads to collocated pipelines exacerbates the negative ecological effects already present with the existing road including increased edge avoidance by a forest interior species, greater barrier effects for all 3 territorial forest songbirds, and increased access for brown‐headed cowbirds into core forest. We support collocation as a mitigation strategy but emphasize restricting overall corridor width to reduce the additional ecological costs associated with this practice.
Tissue proteomics repositories for data reanalysis
Authors: Stroggilos Rafael , Tserga Aggeliki , Zoidakis Jerome , Vlahou Antonia , Makridakis Manousos 
Published: August 2023

AbstractWe are approaching the third decade since the establishment of the very first proteomics repositories back in the mid‐'00s. New experimental approaches and technologies continuously enrich the field while producing vast amounts of mass spectrometry data. Together with initiatives to establish standard terminology and file formats, proteomics is rapidly transforming into a mature component of systems biology. Here we describe the ProteomeXchange consortium repositories. We specifically search, collect and evaluate public human tissue datasets (categorized as “complete” by the repository) submitted in 2015–2022, to both map the existing information and assess the data set reusability. Human tissue data are variably represented in the repositories reviewed, ranging between 10% and 25% of the total data submitted, with cancers being the most represented, followed by neuronal and cardiovascular diseases. About half of the retrieved data sets were found to lack annotations or metadata necessary to directly replicate the analysis. This poses a rough challenge to data reusability and highlights the need to increase awareness of the mage‐tab file format for metadata in the community. Overall, proteomics repositories have evolved greatly over the past 7 years, as they have grown in size and become equipped with various powerful applications and tools that enable data searching and analytical tasks. However, to make the most of this potential, priority must be given to finding ways to secure detailed metadata for each submission, which is likely the next major milestone for proteomics repositories.
Three‐dimensional‐printed dual‐polarized high‐isolation horn antenna at Ka‐band
Authors: Bharath Kunooru , Nandigama Srujana Vahini , Dasari Rama Krishna , PandhariPande Vijay M. 
Published: August 2023

AbstractA dual‐polarized horn antenna with good port‐to‐port isolation is designed at Ka‐band and fabricated using three‐dimensional (3D) printing technology, and the measured results are discussed with simulation data. In order to achieve high port‐to‐port isolation with dual polarization, a metallic via is inserted into the coupled port, which is placed on top of the broad wall input of the horn antenna. The proposed horn is fabricated with the help of a low‐cost atomic diffusion additive manufacturing (ADAM) 3D printing technique using 17‐4PH stainless steel material. The measured reflection parameter at port1 (direct port) is better than 15 dB over Ka‐band, while the measured reflection parameter at port2 (coupled port) is better than 10 dB over 27–29 GHz, the isolation parameter (S21) between the ports is better than 50 dB over Ka‐band, and the cross‐polarization level is at least 30 dB below the copolarization.
Rates and predictors of visits to primary care physicians during and after treatment of childhood acute lymphoblastic leukemia: A population‐based cohort study
Authors: Breakey Vicky R. , Sutradhar Rinku , Nathan Paul C. , Patel Serina , Wheaton Laura , Li Qing , Bassal Mylene , Gibson Paul , Pole Jason D. , Athale Uma , Gupta Sumit 
Published: August 2023

AbstractIntroductionPatient re‐engagement with primary care physicians (PCPs) after cancer treatment is essential to facilitate survivorship care and to meet non‐oncology primary care needs. We identified rates and predictors of PCP visits both during and after treatment among a population‐based cohort of children with acute lymphoblastic leukemia (ALL).MethodsChildren of age less than 18 years at ALL diagnosis in Ontario between 2002 and 2012 were linked to administrative data and matched to controls without cancer. PCPs at diagnosis were identified and PCP visit rates during treatment compared between patients and controls. Post‐treatment PCP visit rates were also calculated. Predictors included demographic‐, disease‐, and PCP‐related variables.ResultsA total of 743/793 (94%) patients and 3112/3947 (79%) controls had a PCP at diagnosis. Almost half of patients (361/743, 45%) did not visit their PCP during treatment. Visit rate during treatment was 0.64 per person per year (PPPY) versus 1.4 PPPY among controls (adjusted rate ratio [aRR] 0.47, 95th confidence interval [95CI]: 0.40–0.54; p < .0001). No disease‐ or PCP‐related factors were associated with visit rates. Total 711 patients completed frontline therapy; 287 (40.4%) did not have a PCP visit after treatment. Nonetheless, survivors overall visited PCPs post treatment more often than controls (aRR 1.4, 95CI: 1.2–1.6; p < .0001). Survivors who saw their PCP during treatment had post‐treatment visit rates twice that of other survivors (aRR 2.0, 95CI: 1.6–2.5; p < .0001).ConclusionsOnly a portion of children with ALL see their PCPs during treatment and return to PCP care following treatment completion. Post‐treatment engagement with PCPs may be improved by PCP involvement during ALL treatment.
A multilevel framework for assessing self‐regulated learning in school contexts: Innovations, challenges, and future directions
Authors: Cleary Timothy J. , Russo Michelle R. 
Published: August 2023

AbstractAs the importance of student self‐regulated learning (SRL) among school‐aged populations continues to increase, there is an emerging need for school psychologists and other school professionals to develop the knowledge and skills to effectively assess this process. The current paper provides a conceptual and empirical overview of a multimethod SRL diagnostic assessment framework included as part of the Self‐Regulation Empowerment Program (SREP). In addition to providing information about the operation and sequence of the SREP diagnostic assessment process, the current paper underscores the commonly used measures of SRL (e.g., self‐report questionnaires, teacher rating scales, SRL microanalysis, think‐aloud protocols) and provides evidence supporting their psychometric rigor and utility in school settings. This paper also serves as a roadmap that school psychologists can use to increase the frequency and quality of school‐based SRL assessments. Future research directions regarding the SREP diagnostic assessment process are also emphasized.
A lower bound for set‐coloring Ramsey numbers
Authors: Aragão Lucas , Collares Maurício , Marciano João Pedro , Martins Taísa , Morris Robert 
Published: August 2023

AbstractThe set‐coloring Ramsey number is defined to be the minimum such that if each edge of the complete graph is assigned a set of colors from , then one of the colors contains a monochromatic clique of size . The case is the usual ‐color Ramsey number, and the case was studied by Erdős, Hajnal and Rado in 1965, and by Erdős and Szemerédi in 1972. The first significant results for general were obtained only recently, by Conlon, Fox, He, Mubayi, Suk and Verstraëte, who showed that if is bounded away from 0 and 1. In the range , however, their upper and lower bounds diverge significantly. In this note we introduce a new (random) coloring, and use it to determine up to polylogarithmic factors in the exponent for essentially all , , and .