bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperbilirubinemia during Atazanavir/Ritonavir Treatment in HIV-infected Patients at Vajira Hospital, a Tertiary Hospital in Thailand
Authors: Maekarsingharak Duangporn , Thinpangnga Peerawit , Munsakul Warangkana 
Published: June 2023

Abstract
Background
Highly active antiretroviral therapy (HAART) in people living with HIV (PLHIV) decreases opportunistic infections; however, long-term HAART use is commonly associated with adverse drug reactions. Although atazanavir/ritonavir (ATV/r) therapy has several advantages, including once-daily dosing, ATV/r-associated hyperbilirubinemia has been frequently reported, with diverse incidence and related factors in many studies. This study investigated the incidence and risk factors of ATV/r-associated hyperbilirubinemia.
Methods
PLHIV who received HAART at the Division of Infectious Diseases and Tropical Medicine, Vajira Hospital, from January 2010 to December 2020 were retrospectively recruited. Data were recorded on a standardized timescale every 6 months. The cumulative incidence of hyperbilirubinemia Grade ≥ II was estimated using the Kaplan–Meier method. Univariate and multivariate Cox proportional hazards models were used to study risk factors.
Results
Of the 2,987 participants, 127 received ATV/r, in this cohort with a mean age of 43.22 ± 10.76 years. The average treatment duration was 5.16 ± 3.14 years and the incidence of Grade ≥ II hyperbilirubinemia was 76.38%. The cumulative incidence (95% CI) of hyperbilirubinemia at 1, 2, 3, 4, 5, and 8 years was 44.63% (36.42–53.78), 65.53% (56.85–74.06), 74.01% (65.44–81.90), 78.96% (70.49–86.35), 81.59% (73.21–88.63), and 90.03% (80.84–95.99), respectively. Abnormal total bilirubin (TB) at baseline and raltegravir coadministration were associated (HR [95% CI]) with a significantly higher risk (1.22 [1.10–1.35], p ≤ 0.001 and 3.36 [1.20–9.48], p = 0.021, respectively) whereas tenofovir and efavirenz coadministration seemed protective (0.42 [0.27–0.65], p < 0.001 and 0.34 [0.16–0.68], p = 0.003, respectively) against hyperbilirubinemia.
Conclusions
Hyperbilirubinemia is a common adverse effect of ATV/r therapy. Abnormal baseline TB level and raltegravir coadministration were significant risk factors of hyperbilirubinemia. Concomitant tenofovir or efavirenz use seemingly decreased the risk of hyperbilirubinemia. Therefore, the risk of hyperbilirubinemia should be considered when selecting other antiretroviral agents in combination with ATV/r.
Evidence of Autoinflammation as a Principal Mechanism of Myocardial Injury in SARS-CoV-2 PCR-Positive Medical Examiner Cases
Authors: Hammond Margo Elizabeth H , Christensen Erik D , Belenky Michael , Snow Gregory L , Shah Kevin , Hammond M Elizabeth H 
Published: June 2023

Abstract
Background
Disease from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains the third leading cause of death in the United States, after cancer and heart disease. Many patients infected with this virus develop later cardiovascular complications including myocardial infarctions, stroke, arrhythmia, heart failure, and sudden cardiac death (20–28%). The purpose of this study is to understand the primary mechanism of myocardial injury in patients infected with SARS-CoV-2.
Methods
We investigated a consecutive cohort of 48 medical examiner cases who died with PCR-positive SARS-CoV-2 (COVpos) infection in 2020. We compared them to a consecutive cohort of 46 age and sex-matched controls who were PCR-negative for SARS-CoV-2 (COVneg). Clinical information available at postmortem examination was reviewed on each patient. Formalin-fixed sections were examined using antibodies directed against CD42 (platelets), CD15 (myeloid cells), CD68 (monocytes), C4d, Fibrin, CD34 (stem cell antigen), CD56 (natural killer cells), and Myeloperoxidase (MPO) (neutrophils and NETs). We used a Welch 2-sample T-test to determine significance. A cluster analysis of marker distribution was also done.
Results
We found a significant difference between COVpos and COVneg samples for all markers, all of which were significant at p < 0.001. The most prominent features were neutrophils (CD15, MPO) and MPO positive debris suggestive of NETS. A similar distribution of platelets, monocytes, fibrin and C4d was seen in COVpos cases. Clinical features were similar in COVpos and COVneg cases for age, sex, and body mass index (BMI).
Conclusion
These findings suggest an autoinflammatory process is likely involved in cardiac damage during these infections.
Study on the Law of Repeated Mining Strata Movement and Surface Subsidence in Close Distance Coal Seam
Authors: Wu Zhoukang , Wang Wencai , Li Tan , Yang Shaochen , Wang Peng , Gao Xiangxiang , Su Baoshan 
Published: June 2023

Abstract
In order to study the characteristics of surface subsidence under the condition of repeated mining of close distance coal seams in Wuhai mining area of the Yellow River Basin, Wuhushan Coal Mine in Wuhai City, Inner Mongolia was taken as the engineering background. By means of theoretical analysis, physical similarity simulation experiment, numerical simulation and field monitoring, the migration law of overlying strata and the determination of maximum surface subsidence value under close repeated mining conditions are studied, and further verified by engineering measurement. Through theoretical analysis, the characteristics of surface subsidence under the condition of close-range repeated mining are studied, and the physical similarity simulation experiment and 3DEC numerical simulation software are used to study the migration law of overlying strata under the condition of close-range repeated mining. The results show that under the condition of repeated mining of close distance coal seams, the migration law of overlying strata and surface of upper and lower coal seams presents four development stages from bottom to top : ' caving stage-fracture development stage-positive trapezoid rising stage-surface subsidence basin formation stage ' ; the distribution law of the maximum subsidence value of the repeated mining surface is not symmetrically distributed, but tends to the cut side ; the surface subsidence coefficient of repeated mining probability integral method in close distance coal seam is corrected. The modified surface subsidence prediction function is used to predict the maximum surface subsidence on site. The error between the surface subsidence prediction curve and the measured curve is 8.9%, which is basically consistent with the measured value. The rationality of the subsidence prediction function of the repeated mining probability integral method in close coal seams is verified. At the same time, the prediction can provide reference for similar working face mining and subsidence control.
Nexus of Public Debt and Banking Stability, What Role for Governance: Evidence from Panel Data estimations for WAEMU’s Banking System
Authors: ASSOUM Feissal , ALINSATO Alastaire Sèna 
Published: June 2023

Abstract

This paper aims to highlight the mediating role of state governance’s quality in public debt effects on banking stability using a sample of 106 banks in the WAEMU area from 2013 to 2019. The results from using the system GMM estimator and a quantile regression with a non-addictive fixed effects approach (QRPD) show that the effect of public debt on banking stability is non-linear and depends on the level of governance. Governance quality mitigates the adverse effect of public debt on banking stability. A governance threshold is identified, showing a minimum level of good quality of governance from which public debt begins enhancing banking stability. We conclude by encouraging the WAEMU countries to significantly improve the quality of governance if they want public debt to promote banking stability.
JEL Classification : C23, G21, H63.
A Chinese medicine formula(Sanzi-huangshi pill) as an adjuvant therapy for lower-risk myelodysplastic syndrome: protocol for a prospective, randomized, open-label, blinded-endpoint (PROBE) trial
Authors: Xu Hao , Hu Qi , Tao Yuchen , Cai Shuyang , Wang Yanlu , Hu Kexin , Xue Tingting , Bao Jizhang , Lu Jiahui 
Published: June 2023

Abstract
Background: Lower-risk myelodysplastic syndrome (MDS) is characterized by the presence of dysplasia, low bone marrow blast percentage, low number and depth of cytopenia(s), and relatively good-risk karyotpic and molecular abnormalities. Lower-risk MDS patients have primarily received supportive care, immunomodulators, and immunosuppressants. New effective regimens or drugs are urgently needed for the treatment of lower-risk MDS owing to the unsatisfactory clinical efficacy. Sanzi-huangshi pill is an arsenic-containing Chinese medicine that has been used as a promising drug for MDS for decades, but its efficacy has not yet been proven by high-quality clinical trial.
Methods: SPIRIT guidelines were followed in drafting this protocol for a randomized controlled multicenter trial. Ninety-two adults with lower-risk MDS are randomly assigned in a 1:1 ratio to Sanzi-huangshi pill group or control group, and all participants are required to receive 6 months of intervention and 18 months of observation. The primary outcome is Overall Response Rate defined as the sum of complete remission, partial remission, cytogenetic complete remission and hematologic improvement accounting for the proportion of total evaluable cases.
Discussion: This is the first randomized controlled trial to evaluate the efficacy and safety of arsenic-containing Chinese medicine as an adjuvant therapy in lower-risk MDS with serum erythropoietin (sEPO) >500 IU/ml. The purpose of this study is to correctly evaluate the position of traditional Chinese medicine in the treatment plan of MDS and to formulate an effective regimen of integrated Traditional Chinese and Western Medicine to provide preliminary clinical evidence.
Clinical Trial Registration: http://www.chictr.org.cn, identifier: ChiCTR2200064230, Registered September 30, 2022.
Design and Simulation of a Highly Sensitive Photonic Crystal Fiber Sensor for Malaria Detection
Authors: MIRED Ilhem , DEBBAL Mohammed , Chikh-Bled Hicham 
Published: June 2023

Abstract
In this word, we investigate a sensor-based photonic crystal fiber with a cladding region composed of four layers of air holes with circular geometry. Two of these holes were filled with hemoglobin. The dispersion behavior was reported numerically, and the proposed PCF was found to exhibit highly sensitive behavior at a wavelength of 1.2µm. Our findings suggest that this PCF shows promising potential for use in blood sensing applications, and may be particularly useful for detecting malaria.
Assessing the prognostic effects of hematologic indices in mortality of patients with methanol poisoning
Authors: Boogar Shahrokh Sadeghi , Hassani Amir Hossein , Shirazi Farnaz Kamali Haghighi , Roozbeh Jamshid , Pakfetrat Maryam , Nikoo Mohammad Hossein , Ostovan Vahid Reza , Khodamoradi Zohre , Kouhi Paryia , Jamali Mohammad Hossein 
Published: June 2023

Abstract
Background: methanol poisoning is an important cause of death, especially in countries where alcohol consumption is forbidden by law. Due to unspecific symptoms, diagnosis of this condition is made by a delay; however, having a prognostic tool for predicting the outcome of patients with methanol poisoning would help physicians stratify the risk imposed to each patient. We aimed to evaluate the prognostic effect of hematologic indices in patients with methanol poisoning.
Methods: In this cross-sectional study, 311 patients with methanol poisoning were evaluated. The hematologic indices of the patients including hemoglobin, mean corpuscular volume, platelets, leukocytes and lactate dehydrogenase levels were extracted from the patient files. The factors were compared in survived and expired patients. The correlation of the hematologic indices and mortality was evaluated using spearman’s correlation test and the ROC curves were drawn.
Results: among the 311 patients who entered in our study, the mean age was 32.56±10.672 and 282 patients (90.7%) were male. Fifty-eight patients (18.6%) expired in our study. The expired patients were older, and had higher leukocytes, MCV, and LDH levels. An LDH higher than 381 had a sensitivity and specificity of 93.5% and 55.1%, respectively for mortality due to methanol poisoning.
Conclusions: leukocytosis, macrocytosis, and higher serum LDH levels were associated with higher mortality in methanol poisoning, and high LDH had the highest prognostic factor for prediction of death in this condition.
Occupational health and safety practices among frontline Medical laboratory staff in the Covid-19 testing centres in the Bono region of Ghana
Authors: Garchie Emmanuel I. A. , Mensah Benjamin Tetteh , Ntiamoah Elvis Oppong 
Published: June 2023

Abstract
Background: Medical laboratory personnel are exposed to various occupational risks, especially during the COVID-19 pandemic. Their role in testing COVID-19 patients puts them at risk of contracting the virus while handling specimens. This study aimed to assess the occupational health and safety practices of frontline medical laboratory staff in COVID-19 testing laboratories in Ghana's Bono region.
Methods: A cross-sectional study was conducted using purposive sampling among medical laboratory staff at five COVID-19 testing centers in the Bono region. Checklists, interview schedules and structured questionnaires were used for data collection. Data analysis was performed using SPSS 20.0.
Results: The study included 137 participants, with 85 (62.0%) aged between 21 and 30 years. Males constituted 96(70.1%) whiles females constituted 41(29.9%) of the study participants. Among the respondents, 55% reported having been infected with COVID-19 before vaccination, 30% after vaccination, and 15% both before and after immunization. The majority of participants (93%) emphasized the importance of adhering to occupational health and safety procedures. Furthermore, 97% believed that standard operating procedures should be regularly reviewed, and 91% agreed that rewards should be provided
for following safety protocols.
Conclusion: The study revealed a positive attitude toward adherence to occupational health and safety protocols among frontline medical laboratory staff in COVID-19 testing centers in the Bono region of Ghana.
Analysis of gastric mucosal commensal bacteria and plasma metabolites across different stomach microhabitats using multi-omic analyses in development of gastric cancer
Authors: Wang Bingsen , Luan Jiahui , Zhao Weidong , Yu Jun bao , Li Anqing , Li Xinxin , Zhong Xiaoqin , Cao Hongyun , Wang Ruicai , Liu Bo , Lu Shiyong , Shi Mei 
Published: June 2023

Abstract
As an important component of microenvironment, the gastric microbiota and their metabolites are associated to tumor occurrence, progression and metastasis. However, the relationship between gastric microbiota and the development of gastric cancer is far from clear. To investigate the role of gastric mucosa microbiome and metabolites as etiological factors in gastric carcinogenesis, gastric biopsies (n=70) and blood samples (n=95) were applied to identify microbial structure and plasma metabolic changes in different stomach microhabitats using multi-omics techniques including the 16S rRNA amplicon sequencing and metabolomics. It was noted that the microbiota diversity and community composition were remarkably changed in different stomach microhabitats during gastric carcinogenesis, especially in the presence of Helicobacter pylori. High H. pylori colonization modified the overall diversity and the composition of the gastric microbiota in gastritis and tumoral microhabitats. Most importantly, the gastric carcinoma microbiota was characterized by reduced abundance of Helicobacter and by the prevalence of other bacterial genera at the developmental stage of gastric cancer, mostly represented by oral cavity and intestinal microbiota. PiCRUSt2 analysis revealed that the nitrate reductase genes were significantly enriched in tumoral microbiota, while urease-producing function was significantly enriched in microbiota of Hp-positive cases. The untargeted metabolomics analysis uncovered 81 metabolites, including 2-methoxyestradiol, 8,9-DiHETrE and leukotriene B4, were significantly different between superficial gastritis and gastric cancer patients and they were related to top 25 signal pathways. On the other hand, uric acid, N-acetylserotonin and phenylethylamine significantly discriminated H. pylori-positive and H. pylori-negative patients with chronic atrophic gastritis. Furthermore, ROC curve analysis identified a series of gastric microbiota and plasma metabolite signatures which might playimportant roles in gastric carcinogenesis and had the potential to be used as biomarkers for diagnosis, making surveillance of gastric cancer patients with a minimally invasive possibility.
The AHP method as a yacht design support used to determine sailing yacht owners' preferences for deck equipment.
Authors: Sierzputowski Jan , Karczewski Artur , Krata Przemysław 
Published: June 2023

Abstract
A sailing yacht is a human-centred product which design revolves primarily around the wants and desires of her future owner. These preferences are in most cases immeasurable e.g., the personal aesthetic feeling, a need of comfort, speed, safety etc. The aims of this paper are firstly to demonstrate that these likings can be classified and represented numerically, and secondly to indicate that they correlate with the type of the owned yacht. As a case study, the owners’ preferences regarding deck equipment are considered. They are determined by pairwise comparisons of the grades of importance of features previously defined by the yacht owners, which is a part of the Analytic Hierarchy Process (AHP) method used in this study. In result a quantitative representation of a studied preferences is established. Furthermore, they correlate with the type of the operated yacht. The findings of the current study show that the yacht owners’ preferences can be represented numerically, what leads to a utilitarian conclusion that concerns the support and even some degree of automation of the design process.
Response of lake dynamics to climate change in the Qilian Mountains from 1990 to 2020
Authors: Zhao Tingting , Zhang Xiaoping , Li Zongxing , Chen Hu , Li Jiayao 
Published: June 2023

Abstract
Lakes are sensitive indicators of climate change. Based on the lake dataset and Landsat remote sensing data, we analyzed the changes in area and number of lakes(> 1km2) in the Qilian Mountains from 1990 to 2020, as well as the boundary changes of lakes(> 100km2). In addition, we discussed the impact of climate change on lake area. The results showed that: (1) From 1990 to 2020, the total area and total number of lakes in the Qilian Mountains showed an overall increasing trend, with a total area increase of 492.47km2 and a total number increase of 10. Among them, Qinghai Lake, Hala Lake, Xiao Qaidam Lake, and Nauru Nor Lake showed an overall expansion trend, while Caka Salt Lake and Da Caidam Lake showed an overall shrinking trend. (2)The main reasons for the expansion of Qinghai Lake and Hala Lake was the increase in precipitation, while the main reason for the expansion of Xiao Qaidam Lake and Nauru Nor Lake was the increase in temperature and precipitation. The main reason for the shrinkage of Caka Salt Lake was the enhancement of evapotranspiration. (3) Lakes in the Qilian Mountains were mainly expanding, which has a good promoting effect on improving the ecological environment of this region and even larger area. However, we should also pay attention to problems such as floods and salt-alkali land caused by lake expansion in a timely manner. In addition, governments and all sectors of society should take corresponding measures to alleviate further shrinkage of Caka Salt Lake.
A transcriptome approach evaluating the effects of Atractylenolide Ⅰ on the secretion of estradiol and progesterone in feline ovarian granulosa cell
Authors: guo yuli , Liu Junping , Zhang Shuangyi , Sun Di , Dong Zhiying , Cao Jinshan 
Published: June 2023

Abstract
Atractylodes macrocephala Koidz (AMK) as eartraditional oriental medicine has been used in the treatment of threatened abortion. Atractylenolide I (AT-I) is one of the major bioactive components of AMK. This study aimed to investigate the effect of AT-I on the secretion of estradiol (E2) and progesterone (P4) of feline ovarian granulosa cells (FOGCs) which is necessary for pregnancy. At first, the prolifeation of FOGCs after AT-I treatment was measured by CCK-8. Then, the synthesis of E2 and P4 were measured by ELISA. Lastly, transcriptome sequencing was used to detect the DEGs in the FOGCs, and RNA-Seq results were verified by RT-qPCR and biochemical verification. It was found that AT-I could promote proliferation and the secretion of E2 and P4 in FOGCs; after AT-I treatment, 137 significantly DEGs were observed, out of which 49 were up-regulated and 88 down-regulated. The DEGs revealed significant enrichment of 52 GO terms throughout the differentiation process (P < 0.05) as deciphered by Gene Ontology enrichment analysis. Kyoto Encyclopedia of Genes and Genomes analysis manifested that the DEGs were successfully annotated as members of 155 pathways, with 23 significantly enriched (P < 0.05). A relatively high number of genes were enriched for the cholesterol metabolism, ovarian steroidogenesis, and biosynthesis of unsaturated fatty acids. Furthermore, the contents of the total cholesterol and low-density lipoprotein cholesterol were decreased by AT-I treatment in the cell culture supernatant. The results indicated that AT-I could increase the ability of FOGCs to secrete E2 and P4, which might be achieved by activation of cholesterol metabolism.