bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretchable and Biocompatible Transparent Electrodes for Multimodal Biosignal Sensing from Exposed Skin
Authors: Kim Minji , Um Hyun‐Kyung , Choi Haemin , Lee Jin Sil , Kim Jihyun , Kim Kyungjin , Noh Eunseo , Han Minwoo , Lee Hyang Woon , Choi Won Il , Lee Seoung Ho , Lee Jung‐Rok , Lee Byoung Hoon 
Published: April 2023

AbstractReal‐time health monitoring technology in daily life requires mechanically robust and transparent electrodes for multimodal biosignal sensing from exposed human epidermis. Here, highly stretchable transparent electrodes comprising a water‐dispersed conductive polymer, poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and a protic ionic liquid (IL), 3‐methylimidazolium:bis(trifluoromethylsulfonyl)amide (p‐MIM:TFSI) are reported. Owing to the high water miscibility of p‐MIM:TFSI and its favorable ion exchange capability with PEDOT:PSS, PEDOT:PSS/p‐MIM:TFSI transparent electrodes show enhanced electrical conductivity (σ = 450 S cm−1) and thin‐film stretchability represented by crack onset strain (εc) exceeding 50%. These electrodes outperform other PEDOT:PSS electrodes processed with an aprotic counterpart, 1‐ethyl‐3‐methylimidazolium(EMIM):TFSI, or a traditional ionic salt, Li:TFSI. The PEDOT:PSS/p‐MIM:TFSI thin‐film electrodes are also biocompatible and conformally adhere to human skin; therefore, multimodal biosignals including electrocardiogram, electrooculogram, and electromyogram with high signal‐to‐noise ratios from exposed epidermis on human faces and arms under various measurement conditions mimicking daily activities are collected. Considering the importance of light penetration through human skin for stable biological activity during biosignal monitoring, the results can broaden the applicability of daily‐use wearable biosignal sensors by applying them to exposed human skin.
Fabrication of highly permeable PDMS@ZIF‐8/PVDF hollow fiber composite membrane in module for ethanol‐water separation
Authors: Liu Wei‐Min , Mao Heng , Wang Yu‐Jie , Li Shen‐Hui , Feng Ying‐Nan , Xu Li‐Hao , Wang Sen , Pei Chan , Zhao Zhi‐Ping 
Published: April 2023

AbstractThe construction of high‐performance MOF‐based hollow fiber composite membrane (HFCM) modules is a significant, yet challenging task for the biofuel production industry. In this study, a novel approach was taken to fabricate PDMS@ZIF‐8/PVDF HFCMs in modules through a facile ZIF‐8 self‐crystallization synthesis followed by pressure‐assisted PDMS infusion for pervaporation ethanol‐water separation. The as‐prepared HFCMs exhibited an ultrathin separation layer (thickness, 370 ± 35 nm), which was achieved through precise regulation of the ZIF‐8 membrane and defect repair by PDMS infusion. Moreover, the strategy utilized in this study resolved the defect issues arising from MOF agglomeration in conventional composite membranes. Impressively, at the optimal packing density, the prepared membrane demonstrated a remarkable ethanol flux (1.11 kg m−2 h−1) with an PSI value (26.59 kg m−2 h−1) and showed promising long‐term stability for the pervaporation of 5 wt% ethanol aqueous solution at 40°C.
Family involvement in euthanasia or Physician Assisted Suicide and dementia: A systematic review
Authors: Scheeres‐Feitsma Trijntje M. , van Laarhoven Angela J. J. M. Keijzer , de Vries Ralph , Schaafsma Petruschka , van der Steen Jenny T. 
Published: April 2023

AbstractObjectiveTo assess how families are involved in situations of euthanasia or physician assisted suicide (PAS) in dementia.DesignSystematic review searching literature in nine databases from inception up to October 2021. We included studies on family involvement in euthanasia from the perspective of persons with dementia and family caregivers. Themes were formulated through thematic analysis. The design was registered at Prospero (CRD42022298215).ResultsWe assessed 215 of 4038 studies in full text; 19 met the inclusion criteria of which 13 empirical studies. Themes included for people with dementia: being a burden; stage of dementia, and permissibility of euthanasia/PAS. Themes for family were the burden of care, responsibility toward the euthanasia or PAS wish, permissibility of euthanasia/PAS.ConclusionThe wish for euthanasia/PAS arises in situations of burdensome care and fear of future deterioration. The family feels entrusted with the responsibility to enact upon the death wish. In shaping this responsibility, four roles of family can be distinguished: carer, advocate, supporter, and performer. Family as in need of support themselves is understudied.
A Comparison Between Early Presentation of Dementia with Lewy Bodies, Alzheimer's Disease, and Parkinson's Disease: Evidence from Routine Primary Care and UK Biobank Data
Authors: Nedelec Thomas , Couvy‐Duchesne Baptiste , Darves‐Bornoz Aube , Couronne Raphaël , Monnet Fleur , Gantzer Laurène , Lekens Béranger , Wu Yeda , Villain Nicolas , Schrag Anette , Durrleman Stanley , Corvol Jean‐Christophe 
Published: April 2023

ObjectiveThe purpose of this study was to simultaneously contrast prediagnostic clinical characteristics of individuals with a final diagnosis of dementia with Lewy Bodies (DLB), Parkinson's disease (PD), and Alzheimer's disease (AD) compared with controls without neurodegenerative disorders.MethodsUsing the longitudinal THIN database in the United Kingdom, we tested the association of each neurodegenerative disorder with a selected list of symptoms and broad families of treatments, and compared the associations between disorders to detect disease‐specific effects. We replicated the main findings in the UK Biobank.ResultsWe used data of 28,222 patients with PD, 20,214 with AD, 4,682 with DLB, and 20,214 healthy controls. All neurodegenerative disorders were significantly associated with the presence of multiple clinical characteristics before their diagnosis, including sleep disorders, falls, psychiatric symptoms, and autonomic dysfunctions. When comparing patients with DLB with patients with PD and patients with AD patients, falls, psychiatric symptoms, and autonomic dysfunction were all more strongly associated with DLB in the 5 years preceding the first neurodegenerative diagnosis. The use of statins was lower in patients who developed PD and higher in patients who developed DLB compared to patients with AD. In patients with PD, the use of statins was associated with the development of dementia in the 5 years following PD diagnosis.InterpretationPrediagnostic presentations of falls, psychiatric symptoms, and autonomic dysfunctions were more strongly associated with DLB than PD and AD. This study also suggests that although several associations with medications are similar in neurodegenerative disorders, statin usage is negatively associated with PD but positively with DLB and AD as well as development of dementia in PD. ANN NEUROL 2023;94:259–270
A Time‐Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW
Authors: Park Youngseon , Taguchi Atsushi , Baidin Vadim , Kahne Daniel , Walker Suzanne 
Published: April 2023

AbstractThe peptidoglycan cell wall is essential for bacterial survival. To form the cell wall, peptidoglycan glycosyltransferases (PGTs) polymerize Lipid II to make glycan strands and then those strands are crosslinked by transpeptidases (TPs). Recently, the SEDS (for shape, elongation, division, and sporulation) proteins were identified as a new class of PGTs. The SEDS protein FtsW, which produces septal peptidoglycan during cell division, is an attractive target for novel antibiotics because it is essential in virtually all bacteria. Here, we developed a time‐resolved Förster resonance energy transfer (TR‐FRET) assay to monitor PGT activity and screened a Staphylococcus aureus lethal compound library for FtsW inhibitors. We identified a compound that inhibits S. aureus FtsW in vitro. Using a non‐polymerizable Lipid II derivative, we showed that this compound competes with Lipid II for binding to FtsW. The assays described here will be useful for discovering and characterizing other PGT inhibitors.
CoN1O2 Single‐Atom Catalyst for Efficient Peroxymonosulfate Activation and Selective Cobalt(IV)=O Generation
Authors: Li Xue , Wen Xue , Lang Junyu , Wei Yan , Miao Jie , Zhang Xiangcheng , Zhou Baoxue , Long Mingce , Alvarez Pedro J. J. , Zhang Lizhi 
Published: April 2023

AbstractHigh‐valent metal‐oxo (HVMO) species are powerful non‐radical reactive species that enhance advanced oxidation processes (AOPs) due to their long half‐lives and high selectivity towards recalcitrant water pollutants with electron‐donating groups. However, high‐valent cobalt‐oxo (CoIV=O) generation is challenging in peroxymonosulfate (PMS)‐based AOPs because the high 3d‐orbital occupancy of cobalt would disfavor its binding with a terminal oxygen ligand. Herein, we propose a strategy to construct isolated Co sites with unique N1O2 coordination on the Mn3O4 surface. The asymmetric N1O2 configuration is able to accept electrons from the Co 3d‐orbital, resulting in significant electronic delocalization at Co sites for promoted PMS adsorption, dissociation and subsequent generation of CoIV=O species. CoN1O2/Mn3O4 exhibits high intrinsic activity in PMS activation and sulfamethoxazole (SMX) degradation, highly outperforming its counterpart with a CoO3 configuration, carbon‐based single‐atom catalysts with CoN4 configuration, and commercial cobalt oxides. CoIV=O species effectively oxidize the target contaminants via oxygen atom transfer to produce low‐toxicity intermediates. These findings could advance the mechanistic understanding of PMS activation at the molecular level and guide the rational design of efficient environmental catalysts.
Exploiting Interactions between Polyoxometalates and Proteins for Applications in (Bio)chemistry and Medicine
Authors: Lentink Sarah , Salazar Marcano David E. , Moussawi Mhamad Aly , Parac‐Vogt Tatjana N. 
Published: April 2023

AbstractThe specific interactions of anionic metal‐oxo clusters, known as polyoxometalates (POMs), with proteins can be leveraged for a wide range of analytical and biomedical applications. For example, POMs have been developed as selective catalysts that can induce protein modifications and have also been shown to facilitate protein crystallization, both of which are instrumental in the structural characterization of proteins. POMs can also be used for selective protein separation and enzyme inhibition, which makes them promising therapeutic agents. Hence, understanding POM‐protein interactions is essential for the development of POM‐based materials and their implementation in several fields. In this Review we summarize in detail the key insights that have been gained so far on POM‐protein interactions. Emphasis is also given to hybrid POMs functionalized with organic ligands to prompt further research in this direction owing to the promising recent results on tuning POM‐protein interactions through POM functionalization.
Biogenic synthesis of δ‐MnO2 nanoparticles: A sustainable approach for C‐alkylation and quinoline synthesis via acceptorless dehydrogenation and borrowing hydrogen reactions
Authors: Ghosh Arnab , Hegde Rajeev V. , Limaye Akshay S. , R. Thrilokraj , Patil Siddappa A. , Dateer Ramesh B. 
Published: April 2023

The sustainable and environmentally benign biogenic synthesis of manganese‐oxide nanoparticles (MnO2 NPs) in a single crystalline δ‐phase and its subsequent synthetic utility have been described. The synthesized δ‐MnO2 NPs were characterized using scanning electron microscopy (SEM), energy dispersive X‐ray (EDX), and X‐ray diffraction (XRD) analysis techniques. The detailed analysis envisages the reduction of Mn(VII) to Mn(IV) was facilitated by various phytochemicals present in the aq. mango leaves extract, avoiding the use of external ligand source. The synthesized δ‐MnO2 NPs were perceived in a single delta (δ) monoclinic crystalline phase, wherein a spherical agglomerated morphology was displayed with a particle size of <5 nm. Further, the utility of newly developed δ‐MnO2 NPs was showcased for alpha‐keto‐alkylation and quinoline synthesis via hydrogen autotransfer and the acceptorless dehydrogenative coupling strategy. Moreover, a series of control experiments, mechanistic elucidation, catalyst recyclability, and a dye removal study were demonstrated.
N‐Heterocyclic Carbene‐Palladium Polymers Network: Recyclable Pre‐catalyst for Effective Suzuki–Miyaura Coupling Reaction in Water
Authors: Huang Wei , Ye Huixian , Li Xiaodan , Li Yuntong , Lin Junyue 
Published: April 2023

AbstractRational design of high‐efficiency N‐heterocyclic carbene (NHC) palladium catalyst is of great importance to modern organic synthesis, especially in chemical and pharmaceutical industries. Herein, we fabricate a polymer network containing N‐heterocyclic carbene palladium (PNNHC‐Pd) catalytic active sites via an immobilization process. The N‐heterocyclic carbene palladium can serve as a promising linkage of polymer network as well as an effective catalytic active site owing to its structural preference and strong σ‐donating ability with palladium species. The results display that N‐heterocyclic carbene palladium disperses homogeneously in polymer network, thus rendering PNNHC‐Pd excellent catalytic activity, high stability and superior reusability in palladium‐catalyzed Suzuki–Miyaura coupling reaction in aqueous medium. This work provides a new insight into the development of heterogenization of homogeneous catalysts based on polymer network.
UBP43 promotes epithelial ovarian carcinogenesis via activation of β‐catenin signaling pathway
Authors: Xie Hongyang , Chen Junyu , Ma Changyan , Zhao Jingjing , Cui Manhua 
Published: April 2023

AbstractDysregulation of the deubiquitinating protease, UBP43, has been implicated in many human diseases, including cancer. Here, we evaluated the functional significance and mechanism of action of UBP43 in epithelial ovarian cancer. We found that UBP43 was significantly upregulated in the tumor tissues of patients with epithelial ovarian cancer. Similar results were observed in OVCAR‐3, Caov‐3, TOV‐112D, A2780, and SK‐OV‐3 cells. Furthermore, in vitro functional assays of A2780 and TOV‐112D cells demonstrated that UBP43 overexpression promoted cell proliferation, migration, and invasion. Upregulation of UBP43 might result in epithelial–mesenchymal transition by inducing the nuclear transport of β‐catenin, which was accompanied by enhanced N‐cadherin but decreased E‐cadherin expression. These malignant phenotypes were reversed by UBP43 silencing. Further investigation revealed that the knockdown of UBP43 inhibited cell proliferation by inducing a cell cycle arrest at the G2/M phase. The oncogenic characteristics of UBP43 were validated in a subcutaneous xenograft mouse model. In vivo, tumor growth was delayed in the UBP43‐silenced group but accelerated after UBP43 overexpression. Finally, we demonstrated that β‐catenin is a key protein in the UBP43‐mediated malignant development of epithelial ovarian cancer. Specifically, overexpression of UBP43 decreased the ubiquitination degradation of β‐catenin and enhanced its protein stability. Also, we observed that the downstream genes of beta‐catenin such as cyclin D1, MMP2, and MMP9 were upregulated due to UBP43 overexpression. Thus, we concluded that UBP43 promoted epithelial ovarian cancer tumorigenesis and metastasis through activation of the β‐catenin pathway, suggesting that UBP43 may be a potential therapeutic target for this intractable disease.
Vital Pulpotomy on immature lower first permanent molars using Portland cement, a case of failure and success—case report with 2 years follow‐up
Authors: Abed Dajma , Bchara Jamila , Bshara Nada 
Published: April 2023

Key clinical messageWhile the importance of vital pulp therapy comes from its ability to promote pulp healing allowing the tooth to continue its development and giving the patient a more convenient treatment, dental practitioners should be more aware of the minor mistakes which they might commit during treatment procedures that could reflect negatively on the treatment's outcome. Developing behavior management skills as well as learning from reported mistakes are beneficial to practitioners to provide a more precise and successful treatment.AbstractVital pulp therapies are known to preserve tooth development and give pulp tissues a chance to heal. Despite the progress of biocompatible materials used in this field, these treatments are still facing some failure for several known and unknown reasons that might not only be related to the material used. This case report presents and discusses the possible reasons for the success of one vital pulpotomy procedure and the failure of another, both conducted on two immature lower first permanent molars of the same patient, in an attempt to conclude what led to both results.
Nickel‐Catalyzed Sequential Dehydrogenation and Cyclization of 2‐Amino(Nitro)‐benzyl Alcohols with Alkyl Alcohols: Synthesis of C‐3‐Substituted Quinolines
Authors: Sk Motahar , Bera Atanu , Banerjee Debasis 
Published: April 2023

AbstractWe herein reported a general and efficient Ni‐catalyzed protocol for sequential double de‐hydrogenative cyclization of 2‐amino(nitro)‐benzyl alcohols with primary alcohols to C‐3‐substituted quinolines releasing water and dihydrogen as by products. As a special highlight, late stage functionalization of cholesterol derivative including chemo‐selective transformations of citronellol, fatty acid derived oleyl alcohol and long chain C4−C14 alkyl alcohols were reported. Initial mechanistic studies including deuterium‐labelling experiments were perform to establish the de‐hydrogenative cyclization.
HIGH‐DEFINITION MODELING OF COMPOSITE BEAMS
Authors: Adhikari Samiran , Rassati Gian A. , Swanson James A. , Chicchi Rachel A. 
Published: April 2023

AbstractThis paper presents a high‐definition modelling approach for the simulation of the flexural behaviour of composite beams that accounts for the principal mechanisms associated with strength, stiffness, and ductility. The goal of the modelling approach presented is to enable parametric studies on the ultimate capacity of composite beams involving different amounts of shear transfer provided, various placement configurations of shear connectors, variable geometry of deck and shear connectors, and different materials. The study presented begins with the simulation of push‐out tests that are validated against experimental results in literature. A recent experiment performed by NIST is used as the validation platform for the study. After validation, some parametric analyses are presented, and it is concluded that the modelling approach discussed herein is appropriate to predict the initial and post‐peak flexural behaviour of composite beams. Recommendations are also made regarding the placement of shear connectors.
INTEGRAL SHEET PILING ABUTMENTS OF MODULAR COMPOSITE BRIDGES FOR A TIME EFFICIENT CONSTRUCTION
Authors: Tibolt Mike , Rademacher Dennis , Hechler Oliver , Wolters Kevin , Rittich Nils , Ivanov Stoyan 
Published: April 2023

AbstractIntegral bridge structures with a high degree of prefabrication comply with all requirements of modern bridge structures. Composite bridges with sheet pile abutments using modular elements are such a solution although not yet a standardized solution with wide acceptance by bridge authorities and owners. In the present paper, two design concepts of a modular connection between superstructure in steel composite construction using hot‐rolled profiles and integral steel sheet pile abutments are presented: A flexible concept with sheet piles as abutments for bridge spans 25‐30m and a more rigid concept applying combined sheet pile walls for bridge spans up to 30‐45m. The concepts are referencing the Knife Edge‐Support (KES) as basis of design. The load paths are analyzed numerically, and the influencing parameters are identified. Finally, preliminary experimental results to proof the suitability of the connections will be confirmed presented.
USE OF HIGH‐ STRENGTH STEEL FOR SLENDER MEDIUM SPAN BRIDGES: TWO RECENT CASE STUDIES IN FRANCE
Authors: Zanon R. 
Published: April 2023

AbstractThis paper presents two cases of existing bridges with prestressed concrete deck replaced by composite steel‐concrete decks. The new decks provide a larger carriage width with increased load carrying capacity according to current design requirements. Furthermore, they have less piers (and therefore larger spans) but still keep the same construction height of the previous solutions. This leads to very slender continuous decks which are an optimal field of application for high‐strength steel. The technical solution adopted is an evolution of the traditional technology of composite steel‐concrete deck, commonly used in the span range between 20m and 40m.
SLENDER COLUMN STRENGTH OF INNOVATIVE CONCRETE FILLED STEEL TUBE COLUMNS WITH HIGH‐PERFORMANCE BUILDING MATERIALS
Authors: Schurgacz Przemyslaw , Neuenschwander Martin , Knobloch Markus 
Published: April 2023

AbstractThis paper presents a comprehensive experimental and numerical study on the load‐carrying behaviour of innovative high performance materials steel‐concrete composite columns: Namely concrete‐filled steel tube columns with solid steel core (CFSTCSC) and concrete‐filled double steel tube columns (CFDST). The experimental results exemplify the basic load‐carrying behaviour. In addition to that, the application range of high‐strength materials is evaluated in relation to the slenderness. Finally, the influence of geometric imperfections on the load‐carrying behavior is investigated based on the manufacturing tolerances of such multi‐component cross‐sections.
SAGGING BENDING RESISTANCE OF COMPOSITE SLABS IN PARTIAL SHEAR CONNECTION
Authors: Sokol Léopold , Palisson Anna 
Published: April 2023

AbstractThis document presents a proposal for improving the partial shear connection method used for the calculation of sagging bending resistance of composite slabs. The improvement is aimed in particular at the equilibrium model of the section of the slab at the ultimate limit state, taking into account the interaction between the tensile force in the sheeting and its resistance moment.
ADVANCED NUMERICAL FIRE DESIGN OF INDUSTRIAL COMPOSITE SLABS WITH UNPROTECTED STEEL BEAMS – A CASE STUDY
Authors: Lequime Pascal 
Published: April 2023

AbstractIn this paper, the development and the application of a framework for advanced numerical thermal and mechanical analysis of a composite slab with unprotected steel beams which is subjected to fire is described. A short overview over existing calculation methods is given to describe the state of the art in fire design of composite slabs. For the numerical model in the software framework SOFiSTiK, the main advantages, features and characteristics are described. To analyse the reliability of the model, the process of validation with existing fire tests is presented. Finally, the model is applied in an engineering project by means of a case study.
ADVANCED ANALYSIS OF STEEL‐CONCRETE COMPOSITE BUILDINGS
Authors: Tran H. , Thai H.T. , Ngo T. , Uy B. , Li D. , Mo J. 
Published: April 2023

AbstractThis paper presents a nonlinear simulation method for composite framing systems constituted from concrete‐filled steel tubular columns (CFST) and composite beam systems. A force‐based fibre beam‐column element in OpenSees was adopted. This element was capable of accurately capturing the local buckling of steel and the confining effect of concrete using the modified stress‐strain relationships of the steel and concrete fibres. A source code for the connection element was also developed in OpenSees to capture the semi‐rigid behaviour of the beam‐to‐column connections of the composite buildings. Through the verification with numerous experiments, the model has shown its capability of accurately simulating composite frames with simplicity and less computational cost. An extensive parametric study was conducted to examine the effect of the bracing systems and the rigidity of the connections on the behaviour and instability of the whole composite buildings.