bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of early and multiple recurrences after curative resection for hepatocellular carcinoma
Authors: Tanemura Akihiro , Noguchi Daisuke , Shinkai Toru , Ito Takahiro , Hayasaki Aoi , Gyoten Kazuyuki , Fujii Takehiro , Iizawa Yusuke , Murata Yasuhiro , Kuriyama Naohisa , Kishiwada Masashi , Mizuno Shugo 
Published: July 2023

Abstract
Purpose: In hepatocellular carcinoma (HCC), postoperative recurrence remains high. This study aimed to evaluate the recurrence patterns and prognosis of HCC after curative hepatectomy.
Methods: Among 339 patients with primary HCC who underwent initial hepatectomy between January 2000 and December 2021, 122 with recurrence were assessed for the relationship between recurrence pattern and prognosis.
Results: The early recurrence group (within 6 months postoperatively; n=28) had significantly higher serum alpha-fetoprotein (p=0.002) and des-𝛾-carboxyprothrombin (p=0.003) levels, larger tumor size (p<0.001), higher incidence of multiple tumors (p=0.016) and portal vein tumor thrombus (PVTT; p<0.001) and lower overall survival (OS) (p <0.001) than the late recurrence group (>6 months postoperatively; n=94).
The multiple recurrence group (intrahepatic multinodular recurrence or distant metastasis; n=94) had significantly higher prognostic nutritional index (p=0.04), larger tumor size (p=0.021), higher incidence of PVTT (p=0.035), and lower incidence of well-differentiated tumor (p<0.001) and liver cirrhosis (p<0.001) than the single recurrence group (single nodule recurrence; n=47). The multiple recurrence group, especially patients with ≥three intrahepatic nodules and distant metastases (p<0.001, p<0.001), had lower postoperative OS and shorter time to recurrence than the single recurrence group.
Conclusion: Early and multiple or distant tumor recurrences are poor prognostic factors after curative resection for HCC.
Performance Evaluation of Universal Filter Multi Carrier (UFMC) and Orthogonal Frequency Division Multiplexing (OFDM) with Amplitude Phase Shift Keying (APSK) Modulation
Authors: Kishore K. Krishna , Kameswari Durga , V JaganNaveen 
Published: July 2023

Abstract
Orthogonal frequency division multiplexing (OFDM) is one of the most important waveform techniques for 4G communications. Despite its many advantages, OFDM has some drawbacks, such as high peak-to-average power ratio (PAPR), sideband leakage, and poor spectrum efficiency. To overcome the previously mentioned shortcomings of OFDM, A novel waveform technique Universal Filter Multi Carrier (UFMC) was introduced as a altered waveform technique for subsequent wireless communication. It is proposed to investigate the performance of the Universal Filter Multi-Carrier (UFMC) system under different modulation schemes. Amplitude phase shift keying is a new modulation technique that is investigated for its ability to minimize the PAPR of the UFMC system and OFDM. APSK has been shown to generate less PAPR than other modulation schemes such as QAM and QPSK, which are commonly, used in LTE communication systems. A comparative analysis is performed between OFDM and UFMC with different modulation schemes, including APSK and it is found that UFMC provides overall better results in terms of PAPR and spectral efficiency compared to OFDM and can be considered as an alternative waveform for 5G communications. The use of filter banks in UFMC helps reduce sideband leakage and improve spectrum efficiency. Additionally, APSK modulation demonstrates its ability to further minimize the PAPR of both UFMC and OFDM systems.
What is the feasibility of using WAST-Short domestic abuse screening tool in primary care? An exploratory cross-sectional study in Northwest London
Authors: Sivarajasingam Vasumathy , Karki Manisha , Bagkeris Emmanouil , El-Osta Austen 
Published: July 2023

Abstract

Background
Domestic abuse (DA) is underdiagnosed in general practice. The primary care workforce plays a key role in the healthcare response to DA. Screening increases the early detection of DA in primary care, but such tools are not routinely used in primary care.
We conducted a cross-sectional study of NHS patients across general practices in Northwest London to explore the use of a short DA screening tool in primary care. We explored the association of history of abuse with the WAST-short score after controlling for demographic characteristics.
Methods
An open, easily accessible anonymous 29-item e-Survey translated into 18 languages and including information on accessible support services was sent to eligible NHS patients (18 years and over) via SMS by general practices in Northwest London. Data was collected from 6,967 NHS patients between 3 March and 7 October 2022.
Participants were asked about their personal experiences of DA. The WAST-short screening questionnaire was used to assess the degree of tension in the respondent's relationship of concern and their perceived difficulty in working out arguments within that relationship. The WAST-Short score was calculated by adding the points allocated to the answers to these two questions. Regression analysis explored the association between WAST-short score and a history of abuse.
Results
Data from 4,253 respondents to the anonymous survey were analysed. Almost half of the respondents confirmed having experienced DA, whereas 6.1% declined disclosure. After adjusting for a priori confounders (age, gender and ethnicity), the multivariable logistic regression model showed that those who disclosed a history of abuse and those who 'would rather not say' had significantly higher odds of having tension in their relationship and higher odds of having difficulty in working out arguments compared to those with no history of abuse.
Conclusions
Screening identifies victims, in particular, the cohort who may be struggling to disclose their experiences of abuse. The use of the validated non-obtrusive two-item WAST-short tool could help with the early identification of DA survivors in primary care. Upskilling health and social care professionals in administering this brief non-threatening screening tool would help raise awareness, identify and support victims.
Long-Term Results of a Digital Hypertension Self-Management Program: Retrospective Cohort Study
Authors: Wu Justin , Napoleone Jenna , Linke Sarah , Noble Madison , Turken Michael , Rakotz Michael , Kirley Kate , Folk Akers Jennie , Juusola Jessie , Jasik Carolyn Bradner 
Published: July 2023

Background
Digital health programs that incorporate frequent blood pressure (BP) self-monitoring and support for behavior change offer a scalable solution for hypertension management.

Objective
We examined the impact of a digital hypertension self-management and lifestyle change support program on BP over 12 months.

Methods
Data were analyzed from a retrospective observational cohort of commercially insured members (n=1117) that started the Omada for Hypertension program between January 1, 2019, and September 30, 2021. Paired t tests and linear regression were used to measure the changes in systolic blood pressure (SBP) over 12 months overall and by SBP control status at baseline (≥130 mm Hg vs <130 mm Hg).

Results
Members were on average 50.9 years old, 50.8% (n=567) of them were female, 60.5% (n=675) of them were White, and 70.5% (n=788) of them had uncontrolled SBP at baseline (≥130 mm Hg). At 12 months, all members (including members with controlled and uncontrolled BP at baseline) and those with uncontrolled SBP at baseline experienced significant mean reductions in SBP (mean –4.8 mm Hg, 95% CI –5.6 to –4.0; –8.1 mm Hg, 95% CI –9.0 to –7.1, respectively; both P<.001). Members with uncontrolled SBP at baseline also had significant reductions in diastolic blood pressure (–4.7 mm Hg; 95% CI –5.3 to –4.1), weight (–6.5 lbs, 95% CI –7.7 to –5.3; 2.7% weight loss), and BMI (–1.1 kg/m2; 95% CI –1.3 to –0.9; all P<.001). Those with controlled SBP at baseline maintained within BP goal range. Additionally, 48% (418/860) of members with uncontrolled BP at baseline experienced enough change in BP to improve their BP category.

Conclusions
This study provides real-world evidence that a comprehensive digital health program involving hypertension education, at-home BP monitoring, and behavior change coaching support was effective for self-managing hypertension over 12 months.
Evaluation of Stratified K-Fold Cross Validation for Predicting Bug Severity in Game Review Classification
Authors: Mayangsari Mustika Kurnia , Syarif Iwan , Barakbah Aliridho 
Published: July 2023

Steam review data provided a lot of information for the game development team, either positive or negative review. It contained an essential point that negative and positive reviews provide crucial information and 7% of positive reviews contained bug reports. These bug reports occurred after the game was released, and many reports of common incidents still exist. If players found an issue in the game, they could report it directly through the review feature provided by the online game platform. Nevertheless, the development team took a long time manually analyzing and categorizing the game review. This study proposed a new approach to automatically categorizing game reviews on Steam based on the bug severity level. Hence, to solve this problem, we suggested introducing a solution based on the research background indicated above. For this experiment, we analyzed reviews on two popular game titles namely, FIFA 23 and Apex Legends. We implemented three different classifiers namely, KNN, Decision Tree, and Naïve Bayes, which would be used to train a dataset to classify the bug severity level. Due to an imbalanced dataset, we performed cross-validation to reduce bias in the dataset. Performance in this model would be evaluated using accuracy rate, precision, recall, and F1 score. As a result, the experiment showed that game reviews of different game titles achieved different accuracy scores. The game review classification for FIFA 23 performed better than the game review classification for Apex Legends. The mean accuracy score of FIFA 23 was 72% with Decision Tree and Apex Legend was 64% with KNN.
Similarities and Differences in the Earth’s Water Variations Signal Provided by Grace and AMSR-E Observations Using Maximum Covariance Analysis at Various Land Cover Data Backgrounds
Authors: Szabó Viktor , Osińska-Skotak Katarzyna 
Published: July 2023

ABSTRACT
The study presents a compatibility analysis of gravimetric observations with passive microwave observations. Monitoring the variability of soil water content is one of the essential issues in climate-related research. Total water storage changes (ΔTWS) observed by Gravity Recovery and Climate Experiment (GRACE), enables the creation of many applications in hydrological monitoring. Soil moisture (SM) is a critical variable in hydrological studies. Advanced Microwave Scanning Radiometer (AMSR-E) satellite products provided unique observations on this variable in near-daily time resolutions. The study used maximum covariance analysis (MCA) to extract principal components for ΔTWS and SM signals. The analysis was carried out for the global area, dividing the discussion into individual continents. The amplitudes of gravimetric and microwave signals were computed via the complex empirical orthogonal function (EOF) and the complex conjugate EOF* to determine the regions for detailed comparison. Similarities and differences in signal convergence results were compared with land cover data describing soil conditions, vegetation cover, urbanization status, and cultivated land. Convergence was determined using Pearson correlation coefficients and cross-correlation. In order to compare ΔTWS and SM in individual seasons, ΔTWS observations were normalized. Results show that naturally forested areas and large open spaces used for agriculture support the compatibility between GRACE and AMSRE observations and are characterized by a good Pearson correlation coefficient >0.8. Subpolar regions with permafrost present constraints for AMSR-E observations and have little convergence with GRACE observations.
Contact hypersensitivity to Indian standard patch test series correlates with disease severity among children with atopic dermatitis
Authors: Handa Sanjeev , Bhattacharjee Rajsmita , Thakur Vishal , De Dipankar , Mahajan Rahul 
Published: July 2023

Background
There is emerging evidence of a relationship between atopic dermatitis (AD) and allergic contact dermatitis (ACD), though the data available are scarce with conflicting viewpoints. We explored the occurrence of contact hypersensitivity among children with atopic dermatitis by patch testing them with the Indian standard series and tried to correlate the presence of contact hypersensitivity with the clinical severity of AD in these children.

Methods
In this single-centre, cross-sectional study, children between 6 months and 12 years diagnosed with atopic dermatitis were included and patch tested with the Indian standard series. Outcome parameters were the proportion of patients having positive patch-test reactions, the proportion of positive patch-test reactions for each allergen and factors associated with patch test positivity in atopic dermatitis.

Results
Of the 136 patients, 80 were boys. The mean age of the study population was 5.6 ± 3.2 years. Twenty-eight (20.6%) patients had patch test positivity at 96 h. Fragrance mix was the commonest allergen, followed by potassium dichromate, cobalt chloride hexahydrate and nickel. SCORing atopic dermatitis (SCORAD) was significantly higher in patients with positive patch tests as compared to patients with negative patch tests (P = 0.009).

Conclusion
Greater disease severity in atopic dermatitis was found to be associated with patch test positivity.

Limitations
Inability to establish relevance in about 50% of the patients was a limitation of our study. Follow-up data regarding the impact of allergen avoidance is not available.
Pembuatan Sabun Mandi Cair Herbal dari Surfaktan Methyl Ester Sulphonate dengan Ekstrak Daun Kelor sebagai Zat Antibakteri
Authors: Mutia Eka , Suryati Suryati , Hakim Lukman 
Published: July 2023

Penelitian ini bertujuan untuk membuat sabun mandi cair dari ekstrak daun kelor dengan variasi volume ekstrak 10 mL, 20 mL, 30 mL, dan 40 mL yang memiliki potensi sebagai antibakteri. Senyawa antibakteri yang terdapat pada daun kelor yaitu saponin, tanin, flavonoid dan terpenoid. Metode yang digunakan adalah metode maserasi dengan menggunakan pelarut aquadestillata. Kemudian dibuat sediaan sabun mandi cair dengan variasi volume ekstrak daun kelor yang telah ditetapkan. Variabel bebas pada penelitian ini adalah ekstrak daun kelor sebanyak 10 mL, 20 mL, 30 mL dan 40 mL. Hasil pengujian tinggi dan stabilitas busa yang paling baik didapat pada volume ekstrak 40 mL dengan ketinggian busa sebesar 20 mm dan stabilitas busa 100%. pH yang paling mendekati pH kulit pada sabun ekstrak daun kelor juga pada volume 40 mL dengan nilai 3,7. Viskositas yang paling baik untuk ekstrak daun kelor pada volume ekstrak 40 mL yaitu 1,5117 cP. Densitas sabun mandi cair ekstrak daun kelor juga didapat pada volume ekstrak 40 mL sebesar 1,036 gr/mL. Diameter zona hambat bakteri tertinggi diperoleh pada ekstrak daun kelor terdapat pada volume ekstrak 20 mL yaitu 23 mm. Secara keseluruhan hasil evaluasi pengujian sabun mandi cair sudah sesuai dengan standar SNI-06-04085-1996.
Pembuatan Pupuk Organik Cair dari Limbah Sayuran dengan Menggunakan Bioaktivator EM4
Authors: Yanti Susi , Ibrahim Ishak , Masrullita Masrullita , Muhammad Muhammad 
Published: July 2023

Pembuatan pupuk organik cair khususnya dari limbah sayuran denganpenambahan bio aktivator EM4 (Effective Microorganisme) bertujuan untuk menentukan pengaruh waktu pembuatan terhadap kandungan Nitrogen (N),Phosfor (P2O5), dan Kalium (K2O) dalam pupuk organik cair, serta menentukan pengaruh bio aktivator EM4 terhadap kandungan N, P, K. Metode pembuatan pupuk organik cair ini yaitu limbah sayuran seperti sawi putih, sawi hijau, kubis dan wortel yang banyak mengandung air dihancurkan sebelum difermentasikan. Kemudian bio aktivator EM4 disiapkan untuk penambahan dalam limbah sayuran yang sudah dikecilkan ukurannya. Limbah sayuran dimasukkan ke dalam wadah, dan larutan bio aktivator EM4 kemudian dimasukkan ke dalam wadah secara merata. Pengambilan sampel dilakukan berdasarkan variasi waktu 8 hari, 10 hari, 12 hari, 14 hari dan 16 hari serta variasi penambahan jumlah bio aktivator EM4 sebanyak 12 ml, 18 ml, dan 24 ml. Hasil penelitian yang terbaik pupuk organik cair terdapat pada penggunaan volume 24 ml dengan kandungan unsur hara makro nitrogen 0,71% fosfor 0,47% pada hari ke 16 sedangkan nilai terbaik kalium 0,30% pada hari ke 8 dengan volume 12 ml. Pupuk organik cair yang dihasilkan sudah memenuhi baku mutu SNI : 19-7030-2015 (Badan Standarisasi Nasional, 2015). Volume bio aktivator EM4 sangat berpengaruh terhadap kandungan N, P, dan K, dikarenakan semakin banyak volume bio aktivator EM4 maka kadar N, P, juga akan semakin tinggi.
PENGARUH PERBANDINGAN MINYAK KEMIRI DAN MINYAK BUNGA LAVENDER TERHADAP SIFAT LILIN AROMATERAPI FORMULASI LILIN AROMATERAPI BERBASIS MINYAK KEMIRI DENGAN PENAMBAHAN MINYAK BUNGA LAVENDER
Authors: Sulhatun Sulhatun , Sarah Sarah , Masrullita Masrullita , Sylvia Novi , Ginting Zainuddin 
Published: July 2023

Minyak kemiri (candlenut oil) yang berarti candle yaitu lilin dan nut yaitu kacang. Sesuai dengan namanya, kemiri juga dapat dijadikan bahan dasar lilin karena kemiri mengandung 55-66% minyak dari berat bijinya. Berbagai penelitian yang berkaitan dengan lilin aromaterapi telah banyak dilakukan terutama dalam memformulasikan essential oil. Namun dalam memformulasikan minyak kemiri sebagai basis lilin belum pernah dilakukan sebelumnya. Tujuan penelitian ini adalah mengkaji pengaruh dari perbedaan formula minyak kemiri dan minyak bunga lavender terhadap basis lilin aromaterapi yang dihasilkan. Penelitian ini dilakukan dengan menimbang soy wax sesuai dengan berat yang sudah ditentukan lalu dilelehkan sempurna. Kemudian, ditambahkan variasi minyak kemiri ( 5,7,10 dan 12 gram ) dan variasi essential lavender oil ( 2, 3, 4 dan 5 gram ) diaduk hingga homogen. Terakhir, dituangkan lilin cair kedalam gelas lilin yang telah dipasangkan sumbu. Pengujian lilin aromaterapi berupa organoleptik, waktu bakar, titik leleh dan kesukaan terhadap aroma. Dari hasil pengujian lilin aromaterapi diperoleh, untuk organoleptik lilin dengan bentuk padat, tidak retak, tidak cacat dan warna yang merata yaitu lilin A1 ( 5 : 2 ), A2 ( 5 : 3 ), A3 ( 5 : 4 ), A4 ( 5 : 5 ), B1 ( 7 : 2 ), B2 ( 7 : 3 ), B3 ( 7 : 4 ), B4 ( 7 : 5 ) dan C1 ( 10 : 2 ). Untuk titik leleh, titik leleh tertinggi yaitu pada formula A1 ( 5 : 2 ) yaitu 44,8⁰C sedangkan titik leleh terendah yaitu formula D4 ( 12 : 5 ) yaitu 38,8⁰C. Untuk waktu bakar, lilin dengan waktu bakar terlama adalah lilin D1 ( 12 : 2) yaitu 12 jam 10 menit. Sedangkan lilin dengan waktu bakar paling singkat adalah lilin A4 ( 5 : 5 ) yaitu 8 jam 26 menit. Dapat disimpulkan bahwa, berdasarkan hasil dari perbandingan formula lilin, semakin banyak minyak kemiri dan minyak bunga lavender yang digunakan maka tekstur lilin akan semakin lunak dan titik leleh lilin akan semakin rendah begitupula sebaliknya. Dan semakin banyak minyak kemiri dan semakin sedikit minyak bunga lavender yang digunakan maka waktu bakar lilin akan semakin lama.
Isolation of Phosphate Solubilizing Bacteria Around Bamboo (Bambusa vulgaris) Clumps Using Natural Media Trap Method
Authors: Furqon Parisya Velayati , Suryadi Bambang Fajar , Hidayati Ernin 
Published: July 2023

Bamboo plant is a potential source of plant growth promoting bacteria (PGPB). Phosphate solubilizing ability is an important characteristic of PGPB. This study aims to isolate phosphate solubilizing bacteria around the bamboo clumps using natural media. The bacteria around the bamboo clumps are trapped using natural media. The media consist of 70 gram cooked rice and 70 gram banana peel. The media were stored in plastic boxes with four types of treatments: 1) tightly closed, 2) covered with tissue, 3) covered with banana leaves, and 4) uncovered (open). Those plastic boxes are placed around the bamboo clump and left for up to 5 days. The trapped phosphate solubilizing bacteria were isolated using Pikovskaya agar. A total of 17 isolates of phosphate solubilizing bacteria were successfully trapped, 8 isolates in cooked rice and 9 isolates in banana peel. The isolates showed a phosphate solubilization index, ranging from 0,2 to 1,40. The isolate NN01 has the highest ability to solubilize phosphate. This isolate was trapped in a cooked rice with an open plastic box condition. NN01 is a Gram positive rod-shaped bacterium. In this study it was revealed that the area of ​​the bamboo clumps is inhabited by various types of bacteria. The natural media of cooked rice and banana peels have a good ability to trap potential phosphate solubilizing bacteria around the bamboo clumps.
Effect of Process Variables, Adsorption Kinetics and Equilibrium Studies of Hexavalent Chromium Removal from Aqueous Solution by Date Seeds and its Activated Carbon by ZnCl2
Authors: Theydan Samar K. 
Published: July 2023

The adsorption of hexavalent chromium by preparing activated carbon from date seeds with zinc chloride as chemical activator and granular date seeds was studied in a batch system. The characteristics of date seeds and prepared activated carbon (ZAC) were determined and found to have a surface area 500.01 m2/g and 1050.01 m2/g , respectively and iodine number of 485.78 mg/g and 1012.91 mg/g, respectively. The effects of PH value (2-12), initial sorbate concentration(50-450mg/L), adsorbent weight (0.004-0.036g) and contact time (30-150 min) on the adsorption process were studied . For Cr(VI) adsorption on ZAC, at 120 min time contact, pH solution 2 and 0.02 adsorbent weight will achieve an amount of 35.6 mg/g adsorbed . While when use date seeds as adsorbent , conditions of 3 solution pH, 0.02 absorbent weight , and 120 contact time gave 26.49 mg/g adsorbed amount. Using both Langmuir, Freundlich and Sips models were explain the dsorption isotherms. It declare that the Sips model fits well with the experimental data with a maximum Cr( VI) adsorption capacity for (ZAC) and granular date stone 233.493 and 208.055 mg/g, respectively . The kinetics data which obtained at different initial Cr(VI) concentrations were examined by using pseudo-first-order, pseudo-second-order, and intra-particle diffusion models . The result gained showed that the second-order model was only describing well the empirical kinetics data of both (ZAC) and granular date seeds. It was noticed that the granular date seeds has adsorption performance lower than the (ZAC).