bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations and requirements for the wavelengths in Rayleigh equation anomaloscopes
Authors: Dain Stephen J. , Hovis Jeffery K. 
Published: January 2023

DIN 6160:2019 is a technical standard that sets requirements for Rayleigh equation anomaloscopes. Table 1 of the standard contains the limits for centroid wavelengths and spectral half power bandwidths (SHBW). The centroid limits are more restrictive than dominant wavelength recommendations. The SHBW limits have no known evidence base and are inconsistent between colors. The spectral characteristics of three commercial anomaloscopes brands were measured using a telespectroradiometer. Only the oculus instruments complied with DIN 6160 Table 1, but all the anomaloscopes complied with published recommendations. All complied with the DIN 6160 bandwidth requirements. This highlights the need to provide an evidence base for such requirements.
Exploration of physical activity knowledge, preferences and support needs among pulmonary hypertension patients
Authors: McCormack Ciara , Kehoe Brona , Cullivan Sarah , McCaffrey Noel , Gaine Sean , McCullagh Brian , Moyna Niall M. , Hardcastle Sarah J. 
Published: January 2023

Objective
Physical activity (PA) is an established adjunct therapy for pulmonary hypertension (PH) patients to mitigate PH symptoms and improve quality of life. However, PA engagement within this population remains low. This study investigated PH patients’ knowledge of PA, recalled advice, exercise preferences and PA support needs.

Methods
Semi-structured interviews were conducted with 19 adults (mean age 50 years; SD ±12 years) diagnosed with PH, living in Ireland. Interview scripts were digitally recorded and transcribed verbatim. Thematic analysis was used to analyse the data.

Results
Four key themes were identified: Lack of PA knowledge; exercise setting preference; accountability and monitoring; and clinician delivered PA information and guidance.

Conclusion
This study found that PH clinicians provide suboptimal PA advice, yet patients desired clinician-delivered PA guidance. Home-based exercise was preferred with monitoring and external accountability deemed as important to facilitate sustained engagement.

Practice implications
PH clinicians are well positioned to play a critical role in assisting and empowering PH patients to engage in PA. Providing training and education to PH clinicians regarding exercise prescription may be beneficial. Further research is needed to evaluate the feasibility and efficacy of home-based exercise interventions to improve quality of life and physical activity in PH.
Do cancer detection rates differ between transperineal and transrectal micro-ultrasound mpMRI-fusion-targeted prostate biopsies? A propensity score-matched study
Authors: Rakauskas Arnas , Peters Max , Martel Paul , van Rossum Peter S. N. , La Rosa Stefano , Meuwly Jean-Yves , Roth Beat , Valerio Massimo 
Published: January 2023

Introduction
High-resolution micro-ultrasound (micro-US) is a novel precise imaging modality that allows targeted prostate biopsies and multiparametric magnet resonance imaging (mpMRI) fusion. Its high resolution relying on a 29 MHz transducer allows real-time visualisation of prostate cancer lesions; this might overcome the inaccuracy of conventional MRI-US fusion biopsy strategies. We compared cancer detection rates in patients who underwent transrectal (TR-B) versus transperineal (TP-B) MR-micro-US fusion biopsy.

Materials and methods
1:2 propensity score matching was performed in 322 consecutive procedures: 56 TR-B and 266 TP-B. All prostate biopsies were performed using ExactVuTM micro-US system with mpMRI image fusion. Clinically significant disease was defined as grade group ≥2. The primary objective was to evaluate the detection of clinically significant disease according to access route. The secondary outcomes were to compare the respective detection rates of random and targeted biopsies stratified per access route and to evaluate micro-US for its potential added value.

Results
47 men undergoing TR-B and 88 undergoing TP-B were matched for age, PSA, clinical stage, prostate volume, PIRADS score, number of mpMRI-visible lesions and indication to biopsy. The detection rates of clinically significant and of any prostate cancer did not differ between the two groups (45% TR-B vs 42% TP-B; p = 0.8, and 57% TR-B vs 59% TP-B; p = 0.9, respectively). Detection rates also did not differ significantly between random (p = 0.4) and targeted biopsies (p = 0.7) stratified per access route. Micro-US targeted biopsy detected 36 MRI-invisible lesions in 33 patients; 19% of these lesions were positive for clinically significant disease. Overall, micro-US targeted biopsies upgraded 2% of patients to clinically significant disease that would have been missed otherwise.

Conclusions
MR-micro-US-fusion TR-B and TP-B have similar diagnostic yields in terms of detection rates of clinically significant prostate cancer. Micro-US targeted biopsy appears to have an additional diagnostic value over systematic and MRI-targeted biopsies.
External cephalic version success rate and associated factors: Experience from a tertiary center in Sub-Saharan Africa: A cross-sectional study
Authors: Sium Abraham Fessehaye , Gudu Wondimu , Urgie Tadesse , Masresha Gebeyehu 
Published: January 2023

Objective
To determine the success rate of external cephalic version (ECV) and its associated factors in an Ethiopian setting.

Material and methods
A total of 152 ECVs performed at the St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia from June 1, 2018, up to March 30, 2019, were analyzed, using a prospective cross-sectional study design. Data were analyzed using SPSS version 21. Chi-square test of association was applied for categorical data analysis. Multivariate logistic regression analysis was used to determine predictors of success of ECV. Odds ratio, 95% CI, and P-value<0.05 were used to describe findings’ significance.

Results
The success rate of ECV was 71.7%. ECV success rate did not differ between multiparous and nulliparous (AOR = 1.4, 95% CI 0.07–2.35), according to abdominal wall thickness status (AOR = 3.5, 95% Cl 0.29–42.40), and between unengaged and engaged presenting part (AOR = 1.1, 95% CI 0.26–4.74). A posterior placenta was associated with ECV success compared to anterior placenta (AOR = 1.14, 95% CI 1.03–2.60). Likewise, cases that experience no pain was associated with a higher ECV success rate (AOR 14.68, 95% CI 1.65–34.97). Soft uterine tone was also associated with a higher success rate compared to tense uterine tone (AOR = 3.89, 95% CI 0.02–0.39). Eighty-four percent of those mothers who had successful ECV had spontaneous vertex vaginal delivery.

Conclusion
The success rate of ECV in this study is found to be 71.7%, which is higher than reports from previous studies. Absence of pain during the procedure, posterior placenta, and soft uterine tone were associated with successful ECV.
Cigarette smoking is associated with Herpesviruses in persons with and without serious mental illness
Authors: Dickerson Faith , Katsafanas Emily , Origoni Andrea , Newman Theresa , Rowe Kelly , Ziemann Rita S. , Bhatia Kamal , Severance Emily , Ford Glen , Yolken Robert 
Published: January 2023

Introduction
Herpesviruses are recognized as major causes of human diseases. Following initial infection, Herpesviruses can undergo cycles of reactivation controlled largely by the immune system. Cigarette smoking is an important modulator of the immune system particularly in individuals with serious mental illness where smoking is associated with increased rates of cardiopulmonary diseases and mortality. However, the effect of smoking on Herpesviruses has not been extensively studied.

Methods
In this nested cohort study, cigarette smoking was assessed in 1323 persons with serious mental illness or without a psychiatric disorder ascertained in a psychiatric health care system and the adjacent community. Participants provided a blood sample from which were measured IgG class antibodies to five human Herpesviruses: Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Herpes Simplex Virus-Type 1 (HSV-1); Varicella Zoster Virus (VZV); and Human Herpes Virus-Type 6 (HHV-6). The associations between smoking variables and antibody levels to the Herpesviruses were analyzed among diagnostic groups in multiple regression models adjusted for age, sex, and race.

Results
Current smoking was significantly associated with higher levels of antibodies to CMV (coefficient .183, 95% CI .049, .317, p<.001, q<.007) and the three EBV proteins (EBV NA –(coefficient .088, 95% CI .032, .143, p = .002, q<.014; EBV Virion – coefficient .100, 95% CI .037, .163, p = .002, q<.014; and EBV VCA – coefficient .119, 95% CI .061, .177, p = .00004, q<.0016). The amount of cigarettes smoked was also correlated with higher levels of antibodies to the three EBV proteins. Interaction analyses indicated that the association between cigarette smoking and levels of antibodies to CMV and EBV was independent of diagnostic group. Cigarette smoking was not significantly associated with the level of antibodies to HSV-1, VZV, or HHV-6.

Conclusions
Individuals who smoke cigarettes have increased levels of IgG antibodies to CMV and EBV. Cigarette smoking may be a contributory factor in the relationship between CMV, EBV and chronic somatic disorders associated with these viruses.
Dual contraception method utilization and associated factors among women on anti-retroviral therapy in public facilities of Bishoftu town, Oromia, Ethiopia
Authors: Bedecha Daniel Yohannes , Gurmu Mosisa Assefa , Gejo Negeso Gebeyehu 
Published: January 2023

Introduction
Dual contraception is a method used to prevent sexually transmitted infections (STIs) including Human Immunodeficiency Virus (HIV) and unintended pregnancies. Prevention of unintended pregnancy in people living with HIV (PLHIV) and ART given to pregnant women to suppress viral load prevent transmission of HIV to children. Counseling and provision of dual contraceptive methods is a very cost-effective method to tackle this double burden among women living with HIV. However, little has been known about utilization of dual methods among HIV positive women in Bishoftu town and its surroundings.

Objective
The aim of this study was to assess dual contraception method utilization and associated factors among reproductive age women who were on antiretroviral therapy in public health facilities of Bishoftu town.

Methods
A facility based cross- sectional study was conducted from November 01 to December 30, 2020. The study participants were selected by using simple random sampling technique. Data were collected using a pretested and structured questionnaire through a face to face interview. Data were processed and analyzed using SPSS version 20. Frequencies and percentages were used to describe characteristics of participants. Bivariable and multivariable logistic regression analyses were used to identify variables which had an independent association with the dependent variable. The degree of association between dependent and independent variables were measured using odds ratio with 95% confidence interval. Level of significance was set at a p-value less than 0.05.

Results
The Magnitude of dual contraceptive utilization of women living with HIV in Bishoftu town was 56.9% (95% Cl (51.6, 62.1). Being married (AOR = 4.33; 95% Cl (1.67, 11.27), not getting pregnant since the start of chronic care follow up (AOR = 2.19; 95% Cl (2.90, 3.70), having a partner positive for HIV (AOR = 2.67; 95% Cl (1.34, 5.32) and having a partner negative for HIV (AOR = 2.38; 95% Cl (1.09, 5.20) were factors independently associated with dual method contraceptive use.

Conclusion
The study showed that use of dual contraceptive methods was low; factors like marital status, partner HIV status, and pregnancy after chronic HIV care follow up were found to be significantly associated with dual contraceptive method use. In addition to ART, use of dual contraceptive methods utilization may play a role in prevention of HIV infection in children and is important in the prevention of unintended pregnancy.
Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic
Authors: Barsola Bindiya , Saklani Shivani , Kumari Priyanka , Sidhu Avtar K. , Dhar Anjoo 
Published: January 2023

Abstract
The most fascinating product of honeybee is propolis. It has an immense role in dentistry, dermatology, and otorhinolaryngology. The increased popularity of propolis as an important remedy is due to its constituents, which have anti-inflammatory, immunomodulatory, antihepatotoxic, anti-cancerous, antifungal, antioxidant, antidiabetic, and antiviral activities. The diverse biological and pharmacological activities of propolis have piqued the interest of many scientists. Many techniques like gas chromatography-mass spectrometry, chromatography, and spectroscopy are being used to identify different propolis constituents. Flavonoids, phenolic acids, and their esters are the most pharmacologically active molecules of propolis and are known to disrupt the replication machinery of the virus corroborating the anti-coronavirus activity of propolis. The main aim of this article is to provide an insight of the increasing theragnostic uses of propolis and its nanoparticles, including their chemical analysis, diverse biological activities, and the necessity for chemical standardization. In this review, we have focused at the promising effects of propolis, its optimization, and its liposomal formulation as a therapeutic intervention for COVID-19 and its accompanying comorbidities.
α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin
Authors: Maor Gali , Dubreuil Ronald R. , Feany Mel B. 
Published: January 2023

α-Synuclein plays a key role in the pathogenesis of Parkinson’s disease and related disorders, but critical interacting partners and molecular mechanisms mediating neurotoxicity are incompletely understood. We show that α-synuclein binds directly to β-spectrin. Using males and females in aDrosophilamodel of α-synuclein-related disorders, we demonstrate that β-spectrin is critical for α-synuclein neurotoxicity. Further, the ankyrin binding domain of β-spectrin is required for α-synuclein binding and neurotoxicity. A key plasma membrane target of ankyrin, Na+/K+ATPase, is mislocalized when human α-synuclein is expressed inDrosophila. Accordingly, membrane potential is depolarized in α-synuclein transgenic fly brains. We examine the same pathway in human neurons and find that Parkinson’s disease patient-derived neurons with a triplication of the α-synuclein locus show disruption of the spectrin cytoskeleton, mislocalization of ankyrin and Na+/K+ATPase, and membrane potential depolarization. Our findings define a specific molecular mechanism by which elevated levels of α-synuclein in Parkinson’s disease and related α-synucleinopathies lead to neuronal dysfunction and death.SIGNIFICANCE STATEMENTThe small synaptic vesicle associate protein α-synuclein plays a critical role in the pathogenesis of Parkinson’s disease and related disorders, but the disease-relevant binding partners of α-synuclein and proximate pathways critical for neurotoxicity require further definition. We show that α-synuclein binds directly to β-spectrin, a key cytoskeletal protein required for localization of plasma membrane proteins and maintenance of neuronal viability. Binding of α-synuclein to β-spectrin alters the organization of the spectrin-ankyrin complex, which is critical for localization and function of integral membrane proteins, including Na+/K+ATPase. These finding outline a previously undescribed mechanism of α-synuclein neurotoxicity and thus suggest potential new therapeutic approaches in Parkinson’s disease and related disorders.
Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback
Authors: Reinhold Kimberly , Resulaj Arbora , Scanziani Massimo 
Published: January 2023

The behavioral state of a mammal impacts how the brain responds to visual stimuli as early as in the dorsolateral geniculate nucleus of the thalamus (dLGN), the primary relay of visual information to the cortex. A clear example of this is the markedly stronger response of dLGN neurons to higher temporal frequencies of the visual stimulus in alert as compared with quiescent animals. The dLGN receives strong feedback from the visual cortex, yet whether this feedback contributes to these state-dependent responses to visual stimuli is poorly understood. Here, we show that in male and female mice, silencing cortico-thalamic feedback profoundly reduces state-dependent differences in the response of dLGN neurons to visual stimuli. This holds true for dLGN responses to both temporal and spatial features of the visual stimulus. These results reveal that the state-dependent shift of the response to visual stimuli in an early stage of visual processing depends on cortico-thalamic feedback.SIGNIFICANCE STATEMENTBrain state affects even the earliest stages of sensory processing. A clear example of this phenomenon is the change in thalamic responses to visual stimuli depending on whether the animal’s brain is in an alert or quiescent state. Despite the radical impact that brain state has on sensory processing, the underlying circuits are still poorly understood. Here, we show that both the temporal and spatial response properties of thalamic neurons to visual stimuli depend on the state of the animal and, crucially, that this state-dependent shift relies on the feedback projection from visual cortex to thalamus.
Menilik Kelayakan Substansi dan Bahasa Buku Ajar Jaminan Sosial Ketenagakerjaan pada Mahasiswa S1 Ilmu Hukum Universitas Negeri Surabaya
Authors: Nugroho Arinto , Rusdiana Emmilia 
Published: January 2023

Buku ajar Jaminan Sosial Ketenagakerjaan tidak tersedia di Prodi S1 Ilmu Hukum, sementara dinamika jaminan sosial utamanya terkait dengan ketenagakerjaan sangat tinggi. Jenis pekerjaan yang beragam dan diantaranya sangat beresiko terjadi kecelakaan kerja, jadi keberadaan buku ajar Jaminan Sosial Ketenagakerjaan menjadi keharusan untuk disediakan. Buku ajar ini dapat digunakan sebagai sumber belajar bagi mahasiswa untuk belajar secara mandiri karena memberi kemudahan bagi mahasiswa dalam mempelajari setiap kompetensi yang harus dikuasainya, sekaligus sebagai wahana pengembangan materi Jaminan Sosial Ketenagakerjaan sesuai dengan tuntutan kurikulum dan kebutuhan belajar mahasiswa. Tujuan Penelitian ini adalah untuk mengetahui kelayakan materi buku ajar, kepraktisan serta keefektifan dari sisi bahasa buku ajar Jaminan Sosial Ketenagakerjaan, penelitian menggunakan pendekatan Analyze, Design, Develop, Implement, and Evaluate (ADDIE). Pengumpulan data dengan angket tertutup yang hasilnya diolah dalam bentuk penskoran dan diskusi dengan para ahli. Data yang diperoleh dari instrumen evaluasi dianalisis secara deskriptif kualitatif, dan menjadi bahan untuk memperbaiki buku ajar. Hasil dan pembahasan menunjukkan bahwa hasil berupa buku ajar masih memerlukan beberapa perbaikan dalam ketiga aspek kelayakan tersebut yakni kelayakan isi, dan kelayakan bahasa serta penyajian. Saran yang diajukan adalah urgensi penyelenggaraan pelatihan dan pendampingan dalam penyusunan buku ajar bagi perguruan tinggi.
Proximate analysis of bamboo culm and wood carbonized at low temperatures: A comparative study
Authors: Yang Go Un , Purusatama Byantara Darsan , Kim Jong Ho , Prasetia Denni , Savero Alvin Muhammad , Kim Nam Hun 
Published: January 2023

To obtain basic data for further use of bamboo culms and wood as eco-friendly bioenergy resources, the proximate analysis of Dendrocalamus giganteus, D. asper, Bambusa vulgaris, Gigantochloa apus, Phyllostachys pubescens, Pinus densiflora, and Quercus variabilis carbonized at 200 to 320 °C at 40 °C intervals was undertaken. Proximate analysis of moisture content, ash content, volatile matter, and fixed carbon content was performed according to JIS M 8812 (2004) with 60-mesh carbonized powder. Carbonized bamboo showed higher ash and volatile content than carbonized wood, whereas carbonized wood had a higher fixed carbon content than carbonized bamboo. At all temperatures, giant bamboo had the highest ash content. In bamboo and wood, the ash and fixed carbon contents increased with increasing carbonization temperature, whereas the volatile substances decreased.
Motives for Assuming and Continuing Family Care: Family Caregivers’ Perspective
Authors: Charenkova Jūratė 
Published: January 2023

Studies have shown that the circumstances and motivation for becoming a caregiver are closely related to the caregiver’s well-being and the quality of care provided, which, in turn, affects the quality of life of the person receiving the care. This article aimed to reveal the motives behind decisions related to an aging relative’s care – motives to assume the caregiving duties and motives to remain in the caregiving role. In total, seven family caregivers participated in semi-structured interviews. Two main themes related to caregiving motivation were revealed: (1) motives to assume the caregiver role, and (2) motives to continue with family care. The results of the research were interpreted using the perspective of self-determination theory (Ryan & Deci, 2000; 2017). This study revealed that key motivational drivers of caregiving decisions were associated with the satisfaction of the three basic psychological needs – autonomy, competence, and relatedness. Meeting these needs in the context of caregiving not only strengthened the caregivers’ motivation to take on the caregiving role but also motivated them to continue with family care, even after the autonomy of care recipients had increased significantly.
Exploring the use of raw honey as a fuel source for microbial fuel cells
Authors: Kpeli Matilda , Donkor Michael K. E. , Tamakloe Reuben 
Published: January 2023

Microbial fuel cell (MFC) technologies are making headway in developing and expanding renewable energy through the conversion of organic matter to electricity. Various substrates can be used in the MFCs technology to enable energy generation, either pure substances or complex mixtures of organic materials. This study aims to consider the feasibility of raw honey as a fuel for mediator-less double-chamber MFC. The cell voltage was monitored in mediator-less double-chamber H2O2 cathode microbial fuel cell. The Mfensi clay partition and the raw honey were analyzed using FTIR-ATR. The results show the highest open-circuit voltage of 1414 mV with a maximum current density of 0.6540 A/m2 and a maximum power density of 247.0 W/m2. These results demonstrate that raw honey can be used for power generation in MFCs and for practical applications.