bluuebunny/crossref_metadata_2025_split huggingface dataset:
swPHoToNs: Toward trillion‐body‐scale cosmologicalN‐body simulations on SunwayTaihuLightsupercomputer
Authors: Liu Zhao , Wang Qiao , Lv Xiaojing , Liu Xu , Meng Hongsong , Zhu Guanghui , Gao Liang , Fu Haohuan , Yang Guangwen 
Published: February 2023

AbstractCosmologicalN‐body simulations have been essential for astronomers to study the formation of nonlinear structures and hypotheses of dark matter, dark energy, etc. The scale of the problem naturally leads to extreme scenarios with billions or even trillions of particles, thus demanding massive computational power and highly efficient algorithms. In this paper, we present swPHoToNs, a Particle‐Mesh (PM) and Fast Multipole Method‐ (FMM) based code that can perform cosmological simulations with trillions of particles efficiently on the Sunway TaihuLight supercomputer. Our design includes three novel optimizations: (1) a multilevel domain decomposition and dynamic load‐balancing scheme; (2) a pipeline strategy for tree traversal and gravity calculation; (3) optimizations for both computation and MPI kernels with consideration of the hardware features. We manage to conduct cosmological simulations which contain up to 1.6 trillion particles, obtaining a sustained performance of 56.3 PFlops with a weak‐scaling parallel efficiency of 80.9% and a computational efficiency of 44.9%.
A 3D map of the lingual artery—The perfect tool for transoral robotic surgeries on the base of tongue
Authors: Ostrowski Patryk , Szczepanek Elżbieta , Niemczyk Kazimierz , Bonczar Michał , Michalczak Mateusz , Batko Jakub , Krawczyk‐Ożóg Agata , Wojciechowski Wadim , Walocha Jerzy , Koziej Mateusz 
Published: February 2023

AbstractBackgroundKnowledge about the anatomy of the lingual artery (LA) is of immense importance when performing procedures on the base of tongue (BOT).MethodsA retrospective analysis was performed to establish morphometric data of the LA. The measurements were performed on 55 consecutive patients who underwent head and neck computed tomography angiographies (CTA).ResultsA total of 96 LAs were analyzed. Additionally, a three‐dimensional heat map (showing the oropharyngeal region from the lateral, anterior, and superior point of view) of the occurrence of the LA and its branches was created.ConclusionThe length of the main trunk of the LA was measured to be 31.94 ± 11.44 mm. This reported distance is thought to be a surgical safe zone when performing transoral robotic surgery (TORS) on the BOT because it represents the area where the LA does not give off any major branches.
Quantifying the impacts of hydraulic infrastructure on tropical streamflows
Authors: Nguyen Binh Quang , Kantoush Sameh A. , Saber Mohamed , Binh Doan Van , Vo Ngoc Duong , Sumi Tetsuya 
Published: February 2023

AbstractHydraulic infrastructures, such as reservoirs and water diversion channels, cause altered streamflow worldwide. Therefore, this study aimed to assess the coupled impacts of reservoir operations and water transfer on downstream streamflow over 42 years (1979–2020) for a tropical river in Vietnam, the Vu Gia Thu Bon (VGTB). We also quantified variations in the multi‐sub‐basin contributions to the water budget associated with hydraulic structure development. Therefore, a semi‐distributed hydrological model, SWAT (Soil and Water Assessment Tool), was developed for the entire VGTB basin considering two plausible scenarios: with a dam and without a dam. In this study, reservoirs substantially affected the streamflow during the 2011–2020 period when 12 cascading hydropower dams were constructed in the Vu Gia sub‐basins. The cascading reservoirs across the Vu Gia River reduced the annual average streamflow by 28.1% during this period, whereas their influence was augmented by 13.9% at reaches further downstream. In contrast, the local reservoir and flow diversions created on the Thu Bon River resulted in a 6.5% increase in streamflow. The upstream reservoir operation significantly increased streamflow at the midstream stations by 27.8% compared to the no‐dam period. The streamflow decreased in the dry season by 5.6% in the Vu Gia sub‐basins and increased by 61.7% in the Thu Bon sub‐basins. However, the impacts decreased in the wet season by 41.3% due to the operation of reservoirs, in which Dak Mi 4 had the most significant influence. It was found that the water diverted to the Thu Bon River was governed and reduced by the cascading hydropower dams. Therefore, the operation of 11 reservoirs has partially compensated for the lost water in the Vu Gia sub‐basins, to which the Dak Mi 4 plant has transferred 19.7 m3/s (14%). Our findings classify the impact of cascading dams and diversion structures and their interaction with climate change.
Training home visitors in mentalization‐based practice: A qualitative case study of clinical supervision in mothering from the inside out
Authors: Peacock‐Chambers Elizabeth , Clark Maria Carolina , Moran Michael , Lowell Amanda , Zayde Amanda 
Published: February 2023

AbstractAttachment‐based interventions are important for improving parent‐child outcomes. These interventions must be scaled and made available to under‐resourced communities. An important part of scaling these interventions is delineating and reproducing high‐quality training, including clinical training which often requires the completion of a supervised case. However, descriptions and guidelines for clinical training are frequently broad or not available in the literature. A detailed description of clinical training could lead to further research to improve the effectiveness and dissemination of evidence‐based interventions. Mothering from the Inside Out (MIO) is an attachment‐based parenting intervention effective at reducing substance use and depression, improving caregiving, and enhancing child attachment. It is now being brought from research to community settings. This paper outlines the didactic and clinical training components of MIO. We then present a qualitative case study of one community‐based counselor participating in the clinical training of MIO and employ qualitative methods to describe the main themes that arose during the training. We aim to illustrate how the trainer assisted the counselor in implementing the core components of MIO, which included (a) refining the language used in MIO sessions, (b) making space to explore mental states, and (c) addressing trauma. We conclude by presenting the implications of these findings.
Research advances in probiotic fermentation of Chinese herbal medicines
Authors: Zhang Xiaoling , Miao Qin , Pan Chengxue , Yin Jia , Wang Leli , Qu Lingbo , Yin Yulong , Wei Yongjun 
Published: February 2023

AbstractChinese herbal medicines (CHM) have been used to cure diseases for thousands of years. However, the bioactive ingredients of CHM are complex, and some CHM natural products cannot be directly absorbed by humans and animals. Moreover, the contents of most bioactive ingredients in CHM are low, and some natural products are toxic to humans and animals. Fermentation of CHM could enhance CHM bioactivities and decrease the potential toxicities. The compositions and functions of the microorganisms play essential roles in CHM fermentation, which can affect the fermentation metabolites and pharmaceutical activities of the final fermentation products. During CHM fermentation, probiotics not only increase the contents of bioactive natural products, but also are beneficial for the host gut microbiota and immune system. This review summarizes the advantages of fermentation of CHM using probiotics, fermentation techniques, probiotic strains, and future development for CHM fermentation. Cutting‐edge microbiome and synthetic biology tools would harness microbial cell factories to produce large amounts of bioactive natural products derived from CHM with low‐cost, which would help speed up modern CHM biomanufacturing.
5‐Hydroxymethylfurfural multimers induce pseudo‐allergic reaction through FcεRI at high doses
Authors: Lu Jiayu , Hou Yajing , Si Min , Zhu Qiumei , Jia Xin , Lv Yuexin , Wang Cheng , He Huaizhen 
Published: February 2023

AbstractUnder acidic and high temperature conditions, 5‐hydroxymethylfurfural (5‐HMF) converted from sugar further produces dimers (Compound II) and trimers (Compound III). The polymers were less reported, and sensitization effect of them was reported in this study. Compounds II and III induced the local and systemic anaphylaxis effect in passive cutaneous anaphylaxis mice model and activated RBL‐2H3 cell inducing [Ca2+] mobilization, resulting in the release of β‐hexosaminidase and histamine in vitro. The gene knockdown assay figured out that Compounds II and III induced degranulation through FcεRI. Further, Compounds II and III had a certain affinity with FcεRI by cell membrane chromatography and may combine on the “proline sandwich” structure indicated by molecular docking. All above suggested Compounds II and III can induce pseudo‐allergic reaction through FcεRI in vivo and in vitro. Our work provides basic research to prove that the newly discovered 5‐HMF transformants, Compounds II and III, induce pseudo‐allergic reaction in vitro and in vivo through FcεRI, which is different pathway from 5‐HMF. In foods with high sugar content, the sensitization of Compounds II and III needs more attention. In high‐sugar foods and medicines, especially traditional Chinese medicine injections, the content of transformants needs to be detected.
Research progress on the cellular toxicity caused by microplastics and nanoplastics
Authors: He Tongwei , Qu Yi , Yang Xinhan , Liu Lingxiao , Xiong Fei , Wang Daqin , Liu Manman , Sun Rongli 
Published: February 2023

AbstractMicroplastics (MPs) are plastic particles of a diameter of less than 5 mm and a major carrier of pollution. In accordance with its diameter range, MPs can be divided into microplastics (100–5 mm) and nanoplastics (<100 nm). In recent years, in addition to the impact of MPs on the environment, the ways in which MPs affect the body has also attracted continuous attention. However, relevant studies on the cytotoxicity of MPs are not comprehensive. Based on the current research, this paper summarizes four main cytotoxic mechanisms of MPs, inducing oxidative stress, damaging cell membrane organelles, inducing immune response, and genotoxicity. Generally, MPs cause cytotoxicity such as oxidative stress, damage to cell membranes and organelles, activation of immune responses, and genotoxicity through mechanical damage or induction of cells to produce reactive oxygen species. Understanding these toxic mechanisms is helpful for the evaluation and prevention of human toxicity of MPs. This paper also analyzes the limitations of current research and prospects for future research into cellular MPs, with the aim of providing a scientific basis and reference for further research into the toxic mechanism of MPs.
Prostate cancer tissue classification by multiphoton imaging, automated image analysis and machine learning
Authors: Gomes Egleidson F. A. , Paulino Junior Eduardo , de Lima Mário F. R. , Reis Luana A. , Paranhos Giovanna , Mamede Marcelo , Longford Francis G. J. , Frey Jeremy G. , de Paula Ana Maria 
Published: February 2023

AbstractProstate carcinoma, a slow‐growing and often indolent tumour, is the second most commonly diagnosed cancer among men worldwide. The prognosis is mainly based on the Gleason system through prostate biopsy analysis. However, new treatment and monitoring strategies depend on a more precise diagnosis. Here, we present results by multiphoton imaging for prostate tumour samples from 120 patients that allow to obtain quantitative parameters leading to specific tumour aggressiveness signatures. An automated image analysis was developed to recognise and quantify stromal fibre and neoplastic cell regions in each image. The set of metrics was able to distinguish between non‐neoplastic tissue and carcinoma areas by linear discriminant analysis and random forest with accuracy of 89% ± 3%, but between Gleason groups of only 46% ± 6%. The reactive stroma analysis improved the accuracy to 65% ± 5%, clearly demonstrating that stromal parameters should be considered as additional criteria for a more accurate diagnosis.
Sciatic nerve injury regeneration in adult male rats using gelatin methacrylate (GelMA)/poly(2‐ethy‐2‐oxazoline) (PEtOx) hydrogel containing 4‐aminopyridine (4‐AP)
Authors: Nemati Mahand Saba , Jahanmardi Reza , Kruppke Benjamin , Khonakdar Hossein Ali 
Published: February 2023

AbstractOne of the most important parts of the body is the peripheral nervous system, and any injuries in this system may result in potentially lethal consequences or severe side effects. The peripheral nervous system may not rehabilitate the harmed regions following disabling disorders, which reduce the quality of life of patients. Fortunately, in recent years, hydrogels have been proposed as exogenous alternatives to bridge damaged nerve stumps to create a useful microenvironment for advancing nerve recovery. However, hydrogel‐based medicine in the therapy of peripheral nerve injury still needs a lot of improvement. In this study, GelMA/PEtOx hydrogel was used for the first time to deliver 4‐Aminopyridine (4‐AP) small molecules. 4‐AP is a broad‐spectrum potassium channel blocker, which has been demonstrated to increase neuromuscular function in patients with various demyelinating disorders. The prepared hydrogel showed a porosity of 92.2 ± 2.6% after 20 min, swelling ratio of 456.01 ± 2.0% after 180 min, weight loss of 81.7 ± 3.1% after 2 weeks, and good blood compatibility as well as sustainable drug release. MTT analysis was performed to assess the cell viability of the hydrogel and proved that the hydrogel is an appropriate substrate for the survival of cells. In vivo studies were performed for functional analysis and the sciatic functional index (SFI) as well as hot plate latency results showed that the use of GelMA/PEtOx+4‐AP hydrogel enhances the regeneration compared to the GelMA/PEtOx hydrogel and the control group.
Impact of adhesive area on cellular traction force and spread area
Authors: Holland Elijah N. , Lobaccaro Deborah , Fu Jianping , García Andrés J. 
Published: February 2023

AbstractCells integrate endogenous and exogenous mechanical forces to sense and respond to environmental signals. In particular, cell‐generated microscale traction forces regulate cellular functions and impact macroscale tissue function and development. Many groups have developed tools for measuring cellular traction forces, including microfabricated post array detectors (mPADs). mPADs are a powerful tool that provides direct traction force measurements through imaging post deflections and utilizing Bernoulli‐Euler beam theory. In this technical note, we investigated how mPADs presenting two different top surface areas but similar effective stiffness influence cellular spread area and traction forces for murine embryonic fibroblasts and human mesenchymal stromal cells. When focal adhesion size was restricted via mPAD top surface area, we observed a decrease in both cell spread area and cell traction forces as the mPAD top surface area decreased, but the traction force‐cell area linear relationship was maintained, which is indicative of cell contractility. We conclude that the mPAD top surface area is an important parameter to consider when utilizing mPADs to measure cellular traction forces. Furthermore, the slope of the traction force‐cell area linear relationship provides a useful metric to characterize cell contractility on mPADs
Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence
Authors: Cao Tingyi , Zhao Jiaxuan , Hong Xiumei , Wang Guoying , Pearson Colleen , Adams William G. , Hu Frank B. , Wang Xiaobin , Liang Liming 
Published: February 2023

ABSTRACT
Although the maternal intrauterine metabolic environment has been recognized to have a profound impact on fetal growth and development with lifelong health implications, to our knowledge, there have been few large-scale birth cohort studies linking the cord metabolome (reflecting both the maternal and fetal metabolic state) with postnatal height measurements across the pediatric age range. Using data from the Boston Birth Cohort, an ongoing prospective birth cohort, this study investigated the association of cord plasma metabolites with children's height from birth to adolescence. Height was analyzed as attained height and longitudinal trajectories. Distinctive cord metabolite types were associated with attained height at different developmental windows: triacylglycerols [TAGs], diacylglycerols [DAGs], cholesterol ester [CEs], phospholipids, amino acids [AAs], acylcarnitines [ACs], and nucleotides in early (age 0–4 years) and middle (age 6–12 years) childhood; various metabolite types other than TAGs in later childhood (after age 14 years). Functional principal component analysis on children's repeated height measurements summarized two typical height trajectory components: loadings on first eigenfunction [FPC1] representing overall height by age, and loadings on second eigenfunction [FPC2] representing speed of pubertal height growth. Although only one cord metabolite was correlated with FPC1 after accounting for multiple testing, the study found 27 metabolites with significant overall effect on FPC2 among females and 18 among males. These metabolites were mostly phospholipids (including phosphatidylethanolamines [PEs], phosphatidylethanolamine plasmalogens [PE_Ps], phosphatidylcholines [PCs], lysophosphatidylethanolamines [LPEs], and lysophosphatidylcholines [LPCs]), AAs, and nucleotides. Their associations with height differed between overweight/obesity (OWO) and non-OWO children, especially among females. In this prospective study of US understudied urban, low-income, racially diverse children, we demonstrated that cord plasma metabolites were significantly associated with postnatal attained height at different age windows as well as height trajectories from birth to adolescence. We also revealed how these associations differed by children's sex and OWO status. Our findings help elucidate metabolic pathways underlying fetal origins of height growth across developmental stages. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Discovery of VEGFR inhibitors through virtual screening and energy assessment
Authors: Reang Jurnal , Sharma Kalicharan , Sharma Prabodh C. , Yadav Vivek , Sharma Vinita , Majeed Jaseela 
Published: February 2023

AbstractVascular endothelial growth factor receptor‐2 (VEGFR‐2) is crucial in promoting tumor angiogenesis and cancer metastasis. Thus, inhibition of VEGFR‐2 has appeared as a good tactic for cancer treatment. To find out novel VEGFR‐2 inhibitors, first, the PDB structure of VEGFR‐2, 6GQO, was selected based on atomic nonlocal environment assessment (ANOLEA) and PROCHECK assessment. 6GQO was then further used for structure‐based virtual screening (SBVS) of different molecular databases, including US‐FDA approved drugs, US‐FDA withdrawn drugs, may bridge, MDPI, and Specs databases using Glide. Based on SBVS, receptor fit, drug‐like filters, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis of 427877 compounds, the best 22 hits were selected. From the 22 hits, hit 5 complex with 6GQO was put through molecular mechanics/generalized born surface area (MM/GBSA) study and hERG binding. The MM/GBSA study revealed that hit 5 possesses lesser binding free energy with more inferior stability in the receptor pocket than the reference compound. The VEGFR‐2 inhibition assay of hit 5 disclosed an IC50 of 165.23 nM against VEGFR‐2, which can be possibly enhanced through structural modifications.
Defining orienting language in the genetic counseling process
Authors: Cook Katherine E. , Baty Bonnie J. , Dent Karin M. , Kaphingst Kimberly A. , Erby Lori H. 
Published: February 2023

AbstractWe defined orienting language in genetic counseling sessions as ‘language intended to direct focus to a particular aspect of the counseling process; a physical, emotional, or cognitive space; or an outcome’. This is a concept expanding on the idea of ‘orientation’ statements in the genetic counseling literature. We propose that orienting language is an important component of effective communication in the genetic counseling process. Our goals were to document the presence of orienting language in genetic counseling sessions with practicing genetic counselors and simulated clients, categorize types of orienting language, and evaluate the purpose of this language. A sample of Genetic Counseling Video Project videotape transcripts was evaluated through consensus coding for orienting language. Orienting language was found to be abundant in the dataset evaluated. Each excerpt was coded for orienting language Strategies and Purpose. The six categories of Strategy codes identified were Logical Consistency, Providing Context, Guidance, Structuring the Session, Anchoring, and Procedural. The six categories of Purpose codes were Counselee Understanding, Guidance, Engagement, Promoting Effective Counselor/Counselee Interactions, Counselee Adaptation, and Relationship Building. Results support our expanded definition of orienting language, which was similar in both cancer and prenatal specialties and across years of counselor experience. Orienting language acts as a series of signposts to help clients navigate the sometimes complex and unfamiliar territory of a genetic counseling session. The introduction of this term into the genetic counseling literature allows its use by genetic counselors to be further evaluated and potentially incorporated into genetic counselor training.
Critical components of genomic medicine practice for non‐genetics healthcare professionals: Genetic counselors' perspectives and implications for medical education
Authors: Coleman Tanner , Bensend Tracy , Mills Rachel , Orlando Lori A. , Doyle Lauren 
Published: February 2023

AbstractGenetic services are increasingly provided by non‐genetics healthcare professionals (NGHPs) with minimal formal training in genetics/genomics. Research demonstrates gaps in knowledge and clinical practices in genetics/genomics among NGHPs, but there is a lack of consensus on the specific knowledge needed by NGHPs to effectively provide genetic services. As clinical genetics professionals, genetic counselors (GCs) have insight into the critical components of genetics/genomics knowledge and practices needed by NGHPs. This study explored GCs' beliefs regarding whether NGHPs should provide genetic services and identified GCs' perceptions of the components of knowledge and clinical practice in genetics/genomics that are most critical for NGHPs providing genetic services. Two hundred and forty GCs completed an online quantitative survey with 17 participating in a follow‐up qualitative interview. Descriptive statistics and cross‐comparisons were generated for survey data. Interview data were analyzed using an inductive qualitative method for cross‐case analysis. Most GCs disagreed with NGHPs providing genetic services, but beliefs varied widely, ranging from disagreement due to perceived gaps in knowledge or clinical skills to acceptance of NGHPs providing genetic services due to limited access to genetics professionals. Across survey and interview data, GCs endorsed the interpretation of genetic test results, understanding implications of results, collaboration with genetics professionals, knowledge of the risks and benefits to testing, and recognizing indications for genetic testing as critical components of knowledge and clinical practice for NGHPs. Several recommendations for improving the provision of genetic services were provided by respondents including educating NGHPs to provide genetic services through case‐based continuing medical education and increasing collaboration between NGHPs and genetics professionals. As GCs are healthcare providers with experience and vested interests in educating NGHPs, their perspectives can help inform the creation of continuing medical education to ensure patients' access to high‐quality genomic medicine care from providers of varying backgrounds.