bluuebunny/crossref_metadata_2025_split huggingface dataset:
Η χρήση της μεθόδου της αναστοχαστικής ομάδας από το χώρο της Συστημικής Οικογενειακής Θεραπείας στην Εκπαίδευση Ενηλίκων: απόψεις ειδικών ψυχικής υγείας – εκπαιδευτών/τριών ενηλίκων
Authors: Dedousi Niki 
Published: January 2023

Σκοπός της παρούσας έρευνας είναι η επίτευξη της σύνδεσης των επιστημονικών περιοχών της Ψυχολογίας και της Εκπαίδευσης Ενηλίκων, επιχειρώντας τη διερεύνηση των απόψεων ειδικών ψυχικής υγείας – εκπαιδευτών/τριών ενηλίκων για τη χρήσης της μεθόδου της αναστοχαστικής ομάδας από το χώρο της Συστημικής Οικογενειακής Θεραπείας, στην Εκπαίδευση Ενηλίκων ως ένα εφαλτήριο για την προαγωγή της μετασχηματίζουσας μάθησης. Τα ερευνητικά ερωτήματα αφορούν τη διερεύνηση της δυνατότητας της αναστοχαστικής ομάδας να λειτουργήσει ως εργαλείο μετασχηματισμού, την ανάδειξη των προϋποθέσεων για την ανάπτυξη του κριτικού στοχασμού κατά τη χρήση της αναστοχαστικής ομάδας καθώς και τα πιθανά εμπόδια που μπορεί να αναδυθούν σε αυτή τη διαδικασία. Για το σκοπό αυτό χρησιμοποιήθηκε η ποιοτική μεθοδολογική προσέγγιση, διεξήχθησαν ημι-δομημένες συνεντεύξεις σε εννέα ειδικοί ψυχικής υγείας, οι οποίες έχουν εκπαιδευτεί και στην Εκπαίδευση Ενηλίκων και τα δεδομένα τα οποία εξήχθησαν αναλύθηκαν με τη μέθοδο της θεματικής ανάλυσης. Τα σημαντικότερα συμπεράσματα τα οποία προέκυψαν σχετίζονταν αρχικά με τις παραμέτρους της αναστοχαστικής ομάδας που μπορούν να ενισχύσουν τη μετασχηματιστική της λειτουργία, όπως η πολυφωνία, η απόσταση και το κλίμα που δημιουργείται μέσα στην ομάδα. Επιπλέον, αναδείχθηκε η αναγκαιότητα του να προηγηθεί εκπαίδευση των ατόμων που θα συμμετέχουν στη διαδικασία και η αξιοποίηση της αναστοχαστικής ομάδας σε αντικείμενα ανθρωπιστικών επιστημών ή σε συναντήσεις που αφορούν την προσωπική ανάπτυξη. Μερικά από τα εμπόδια που οι συμμετέχουσες ανέφεραν ότι μπορεί να ανακύψουν ήταν η δυσκολία που σχετίζεται με την αναγκαία έκθεση των ατόμων κατά τη συμμετοχή τους στην αναστοχαστική ομάδα, την ενεργοποίηση μηχανισμών άμυνας καθώς και την απροθυμία του φορέα. Τέλος, υπογραμμίστηκε από την πλειονότητα η σημαντικότητα του ρόλου του/της εκπαιδευτή/τριας ενηλίκων για την έκβαση της χρήσης της μεθόδου της αναστοχαστικής ομάδας στην Εκπαίδευση Ενηλίκων.
Mental health interventions targeting children and young people: A mapping review of interventions, follow-up, and evidence gaps
Authors: Dahlgren Astrid , Borren Ingrid , Axelsdottir Brynhildur , Elvsåshagen Mari , Nilsen Karianne Hammerstrøm 
Published: January 2023

Background: Young people with mental illness should be offered evidence-based treatments. In 2018, we developed a national evidence portal in Norway providing mental health professionals and others with living evidence summaries. This immense work has been an important contribution to mental health care in Norway but is also a rich data source for exploring the characteristics and evidence gaps of the existing research internationally. At the time of this study, eight overviews of systematic reviews (OoOs) had been published. These addressed treatments for attention deficit / hyperactivity disorder (ADHD), anxiety, depression, bipolar disorder, psychosis, obsessive compulsive disorder (OCD), self-harm and trauma/ post-traumatic stress disorder. The objective of this study was to do a secondary analysis of this evidence to describe the state-of-the art in this field, and to map: treatments evaluated for each patient group and the longest time of follow-uptreatment comparisons evaluated for more than one patient group Methods: We performed a mapping review of the eight OoOs. Data extraction was performed by one author and double-checked by another. All data was entered into Excel. Findings were visualized in descriptive tables and using Sunburst-diagrams. We used statistical thresholds to determine the size of effect and report the associated certainty. Results: We identified 200 treatment comparisons including a wide variety of interventions. Some mental illnesses are treated mostly with pharmacological or combination therapies and others solely with psychological or psychosocial treatments or with more diversity. The evidence supporting most treatments is of low to very low certainty. Ten percent of the comparisons included follow-up assessments beyond 12 months. Cognitive behavioural therapy, dialectic behavioural therapy, physical activity and mindfulness interventions were effective across populations. Conclusions: The evidence supporting treatment of mental illness in young people has important limitations. Future research efforts should address these evidence gaps.
Degree of organ damage and inflammatory markers in sepsis mice models inducted by various doses of lipopolysaccharides
Authors: - Arifin , Purwanto Bambang , Indarto Dono , Wasita Brian , Sumanjar Tatar , Poncorini Eti , - Soetrisno 
Published: January 2023

Background: Sepsis is a life-threatening disease, and animal models of sepsis are minimal. This study aims to find the optimal dose to make a sepsis mouse model by examining the presence of target organ damage. Methods: This study used 30 mice divided into four groups. The control group injected 0.5 cc NaCl 0.9% intraperitoneally (i.p.). Group A was injected with lipopolysaccharides (LPS) 0.25 mg/kg B.W. i.p. given on the first and second day, group B was injected with LPS 0.3 mg/kg B.W. i.p. given on the first and second days, and group C was injected by LPS 0.3 mg/kg B.W. single dose i.p. Each group was terminated on the third, fourth, and fifth days. Results: NF-κB, C-reactive protein (CRP), alanine aminotransferase (ALT), NF-κB examinations, and tumor necrosis factor-α (TNF-α) in all treatment groups increased when compared with the control. The highest degree of histopathological features of the kidneys and liver and the results of immunohistochemistry examinations on the liver and kidneys were shown in group C. Conclusions: Inflammatory markers (CRP, TNF-α, NF-κB, and expression of NF-κB in liver and kidneys) and characteristics of organ damage (ALT, liver, and kidneys histopathology scores) increase on day 3. The highest increase was in the group administered with LPS 0.3 mg/kg B.W. single dose.
Practice and knowledge of dietary supplement consumption among Indonesian adults post-delta wave of the COVID-19 pandemic
Authors: d'Arqom Annette , Nasution Mhd Zamal , Kadir Sharifah Zamiah Syed Abdul , Yusof Junaidah , Govindaraju Kayatri 
Published: January 2023

Background: Increasing dietary supplement (DS) consumption was observed during the COVID-19 pandemic, including during the post-Delta wave period. This study aimed to measure the practice of DS consumption and respondents’ knowledge of DS. Methods: An internet-based survey was distributed from October-December 2021 and obtained 541 valid and completed responses. Descriptive analysis was performed to present the practice of DS consumption, including frequency, duration, aim, preferable dosage form etc. Level of knowledge on DS principles, side effects and regulation were also measured. Inferential analyses were conducted to determine the predictors of the respondents’ DS practice and level of knowledge. Results: Data from 541 valid responses showed that 77.63% of respondents consumed DS in the last 3 months, with only 59.52% reporting also consuming DS before the COVID-19 pandemic. One half of the respondents had good knowledge about DS; however, some knowledge regarding side effects and possible drug-supplement interaction needed improvement. Their DS consumption practice was affected by their economic status and history of contracting COVID-19. Nevertheless, the level of knowledge was not affected by the sociodemographic factors and DS supplement experience. Conclusions: Taken together, the practice of self-consumption of DS in Indonesia is increasing; hence, knowledge of DS is necessary to avoid detrimental effects that might occur in the future. Increasing access to information on better labelling and educating consumers about DS are important actions to consider.
Case Report: Right atrial organized thrombus three years after tricuspid annuloplasty
Authors: Abbass Mohannad , Mariani Silvia , Musa Sami , Erba Nicoletta , Masini Franco , Lentini Salvatore 
Published: January 2023

Background: Occurrence of right atrial masses, especially in patients with history of cardiac surgery, is rare. Differential diagnosis between malignant and non-malignant aetiologies might be cumbersome, and surgery is often required to prevent complications or disease evolution. Case: We report the case of a 16-year-old girl from a rural area of Sudan, who underwent surgery for a modified De Vega’s tricuspid annuloplasty, and mitral and aortic valve replacement with mechanical prostheses. The patient was on regular follow-up but demonstrated a poor compliance to anticoagulation therapy with a time in therapeutic range between 52% and 20%. She remained asymptomatic, but a right atrial mass was diagnosed by transthoracic echocardiography during a follow-up visit 41 months after the first operation. Surgical removal of the mass revealed an organized thrombus arising from the point where the Prolene stitches for the tricuspid annuloplasty were previously passed. The patient recovered from surgery, was discharged home on post-operative day 10 and the first follow-up visit at 30 days after discharge confirmed a good clinical status and a normal transthoracic echocardiography (TTE). Conclusions: This case report describes the diagnostic and therapeutic work-out of a thrombus formation on the suture lines of a tricuspid annuloplasty. Moreover, it highlights the importance of a strict and long follow-up after valvular surgery and of the adherence to anticoagulation therapy, especially for patients living in rural areas of developing countries.
Ovarian sclerosing stromal tumor - benign neoplasm of the young. A case study with literature review
Authors: Grzybowski Jakub , Piętak Patrycja , Merkisz Konrad , Nemeczek Sylwia , Marciniak Agnieszka , Walczak Klaudia , Jaskuła Karolina , Orłowski Władysław , Zdun Sylwia , Grzywna Natalia , Walczak Patrycja 
Published: January 2023

Sclerosing stromal tumor (SST), located in the ovary, is a very rare disease entity. To date, only a few hundred cases of ovarian SST have been confirmed worldwide. Preoperative diagnosis of stromal tumor is difficult, as clinically and radiologically it resembles other types of ovarian tumors. These tumors present nonspecific symptoms, with irregular menstrual bleeding, lower abdominal pain and palpable pelvic lesions being the most common. Differentiation and diagnosis is possible only thorough histopathological examination and immunophenotyping. In the present study, we presented a case report of a young, 20-year-old patient with an oligosymptomatic ovarian stromal tumor. We compared and summarized the diagnostic and therapeutic process, as well as the tumor immunophenotypes, with recent cases reported in the literature.
Outcomes of Dementia Among Dialysis Patients: A Nationwide Population-Based Study in Taiwan
Authors: Shen Hsiu-Chu , Chien Chih-Chiang , Weng Shih-Feng , Wang Jhi-Joung , Kuo Jinn-Rung , Lin Kao-Chang 
Published: January 2023

Background: High prevalence of cognitive impairment or dementia is associated with end-stage renal disease (ESRD). The risk for dementia and its prognostic significance remain unclear. This study aimed to determine the prevalence, correlations and outcomes of dementia in chronic ESRD dialysis patients. Methods: Using Taiwan National Health Insurance Research Database (NHIRD), we analyzed ESRD patients who received dialysis between 1999 and 2005 to determine the associations between baseline dementia and subsequent outcomes after dialysis. The cumulative survival rate after dialysis was calculated using the Kaplan-Meier method. Cox proportional hazards model was used to identify the risk factors for all-cause mortality. Results: A total 51,238 incident dialysis patients were examined in this study, including 867 patients with dementia. The prevalence of dementia was increasing with age. The proportional rate of dementia in elderly (?75) patients was 10 times higher than that in aged 18~44 years old of baseline. The co-morbidity with cerebrovascular disease was independently associated with dementia in dialysis population. The 1-, 5-, and 9- year cumulative survival rate were 82.1, 32.7, and 16.5% in ESRD patients with dementia, and 93.5, 62.8, and 41.6% in those without dementia (log-rank: p <0.001). ESRD patients with dementia were associated with 53% higher death risk than those without dementia (HR 1.53, 95% CI: 1.40-1.68). Conclusions: Dementia was associated with poor outcome and co-morbidities among ESRD dialysis patients.
Frequency of Primary Torsion Dystonia for the Population of Bulgaria – A Service-Based Survey
Authors: Semerdjieva N. , Milanov I. 
Published: January 2023

Background: According to the majority of epidemiological studies for primary torsion dystonia (PTD), it is a rare disease, although there are some controversial data, showing much higher figures. Because the need of clarification in this field, the aim of this study is to estimate the frequency of primary torsion dystonia in the Bulgarian population. Materials and Methods: We made an official inquiry to the National Center for Health Information, and to the National Health-Insurance Fund for the total count of all the patients, registered with the diagnose of PTD for a period of a year. Simultaneously we examined the archive of the University Multidisciplinary Hospital for Active Treatment of Neurology and Psychiatry - UMHATNP “St. Naum” in Sofia, with a specialized department of Movement Disorders, for the period of 01.01.2008-01.01.2012. Results: Crude annual prevalence of primary torsion dystonia estimated in this study is significantly lower than most reported epidemiological findings on prevalence. Probably the actual prevalence is higher than that calculated in the current study, but this could be demonstrated by improving the collection of data and methods for screening and diagnosis. Conclusions: The downside of this study, as with most studies in this area worldwide, is that it is based on the demand of medical care. Thus remain not estimated all undiagnosed and and incorrectly diagnosed cases and patients that have not sought medical attention. The majority of the patients in our sample came from the South-Western Region of the country. According to distribution by form of dystonia, age, gender and time to diagnose our results with some exceptions are similar to those, reported in the literature.
Effects of Botulinum Toxin A on Histology and Ultrastructure of Submandibular Salivary Gland in Rats
Authors: Abdelfattah Mohamed Yehia , Sherif Hany Abdel-Hamied , Dameer Hesham Ahmed , Abouzid Wael , Liu Zi-Jun 
Published: January 2023

Introduction: Botulinum toxin A (BoNTA) has been used for treating hyperfunction of various glands such as sweat, lacrimal, and salivary glands. However, the long-term histological sequences are largely unknown.
Objectives: The present study is to evaluate the histological and ultrastructural effects of BoNTA on submandibular salivary gland (SSG).
Methods: Eighteen 6-week-old male albino rats received 0.1 ml of either saline (sham group, n=9) or BoNTA (BoNTA group, n=9) injection in the right SSGs. Of 9 rats in each group, 3 were terminated at 2, 4 and 12 weeks after the injection. The harvested SSGs were embedded and sectioned at 6µm, and stained with H&E for histological study. Ultrathin sections (60-90nm) were cut from1 mm3 pieces harvested from the center of SSGs, and mounted on copper grids for ultrastructural study using transmission electron microscope (TEM).
Results: All sham SSGs showed normal acinar cells with rounded nuclei and regular striated ducts (SD) with characteristic basal striations. By TEM, acinar cells exhibited rounded nuclei, mitochondria, and secretory granules at cytoplasm. Numerous mitochondria presented in SD. Compared with these features, 2-week BoNTA-injected SSGs showed loss of spherical fashion and basal striations in serous acini and SD respectively, and the cell boundaries were not clear. TEM further revealed irregular nuclei of acinar cells and SD, and swollen mitochondria. In 4-week SSGs, some acini and ducts lost their spherical fashion and in some areas, these structures disappeared. Ruptured mitochondria were observed in acini and SD by TEM. However, all 12-week BoNTA-injected SSGs seemed to have similar structures to those of sham SSGs. By using scoring system for semi-quantifying the histological structural changes of BoNTA-injected SSGs, 2- and 4-week BoNTA-injected SSGs showed significantly higher scores as compared with their sham counterparts. However, no significant score difference was found between 12-week BoNTA-injected and sham SSGs.
Conclusions: Although application of BoNTA results in significant changes in histological structures and ultrastructures of SSGs, these detrimental effects seems to be transient, and the major recovery occurs in 3 months. Thus, BoNTA can be used for treating SSG hyperfunction.
Wear Patterns of Adhesive Interfaces over Different Materials
Authors: Comba A. , Baldi A. , Bonito M. , Blanc E. , Notaro V. , Alovisi M. , Pasqualini D. , Berutti E. , Scotti N. 
Published: January 2023

Purpose: The aim of this in vitro study was to investigate differences in surface wear of enamel-material and dentin-material bonded interfaces obtained from upper molars samples and subjected to cycling occlusal load.
Methods: Forty-eight flat specimens of enamel-material and dentin-material bonded interfaces were prepared using different restorative materials with both CAD-CAM techniques and direct techniques. After the bonding and cementation procedures specimens were tested with a chewing machine with a stainless-steel ball on flat sliding contact (20N loads, 50.000 cycles). Wear analysis and comparison of the enamel or dentin substrates and the three restorative materials was performed using a 3D profilometer and analyzed with ANOVA test and post-hoc comparison procedures. Finally worn surfaces were examined with optical microscopy.
Results: Statistical analysis after simulated chewing cycles identified a significant influence of the factor “substrate” (p<0.05) and of the factor “restorative material” (p<0.05). The enamel results in being more wear resistant than dentin, and also more resistant than all the restorative materials tested. Considering the materials, the most severe wear loss was observed with micro-hybrid composite paste. CAD-CAM materials showed a wear rate significantly better both in association with enamel and dentin. An interesting wear pattern was found at the bonded interface level and the oval shapes obtained from the profilometer images underlined a repetitive wear pattern with the central zone more consumed and decreasing depth moving towards the perimeter. Initials signs of cracks were showed in enamel interfaces at the optical microscopy analysis.
Conclusions: Both the dental substrate and the restorative material significantly affect the wear behavior of a toothmaterial interface after cyclic fatigue. Thus, the initial null hypotheses were rejected.
Investigation of Atmospheric Pollution by Biomonitoring of Major and Trace Elements in an Industrial Region
Authors: Kara Melik , Odabasi Mustafa , Dumanoglu Yetkin , Falay Ezgi Ozgunerge , Tuygun Gizem Tuna , Altiok Hasan , Bayram Abdurrahman , Tolunay Doganay , Elbir Tolga 
Published: January 2023

Spatial variations and sources of atmospheric pollution by measuring of 48 major and trace elements were determined in Iskenderun industrial region using tree components samples (pine needle, bark, branch, stem and litter) and soil samples taken from 21 industrial sites and 6 background sites. The highest elemental concentrations were found at industrial sites and generally a decreasing trend with distance was observed. For most of the crustal elements, contamination factors (CF, element concentration in polluted area/element concentration in background area) were low (< 2). For Bi, Cr, Pb, Sn, and Zn, the Iskenderun region was classified as seriously contaminated (8 < <CF> < 27), while for several elements, including Cd, Ag, Cr, As, Fe, Mn, Sn, Mo, Se, Pb, Ni, Sb and Zn the region was classified as moderately contaminated (3.5 < <CF> < 8). Sources of trace elements in Iskenderun industrial region were investigated using Principal Component Analysis (PCA). PCA have identified four factors as crustal-resuspended particulate matter, iron-steel plant emissions, marine aerosol, and accumulation of nutrient elements on plants. Spatial variations of anthropogenic-based trace elements supported the finding that iron-steel facilities are their major sources in the Iskenderun industrial region. Results of this study confirmed that tree components and litter can be used as passive samplers to explore the geographical distribution of atmospheric pollution.
Polymeric Coatings for Drug Delivery by Medical Devices
Authors: Anghel Sanziana , Mahmood Muhammad Arif , Matei Consuela Elena , Visan Anita Ioana 
Published: January 2023

An analysis of the current landscape of therapeutics and delivery methods was conducted, aiming the field of drug delivery systems. Drug delivery biodistribution characteristics should be systematically understood, in order to maximize the function of these delivery systems. As a result, this review covers a history of the drug delivery systems, as well as the basic terminology associated with them, with a focus on the usage of polymers in the drug administration systems (particularly in form of coatings) and their application.
New trends in nanomaterials-based drug delivery systems, primarily for cancer treatment, were presented, involving a technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile.
There is a justified need to investigate drug delivery systems in form of thin films because, in comparation to bulk drug delivery system, which have a long and comprehensive history, there is still insufficient and fragmented understanding about the delivery of thin polymeric films, with research limited in general to very specific cases. Our efforts have been concentrated on these specifically polymeric drug delivery systems in the form of coatings. Understanding the dynamic changes that occur in a biodegradable polymeric thin film can aid in the prediction of the future performance of synthesized films designed to be used as implantable medical devices.
Extensive research is required to continuously develop new therapeutic systems in order to achieve an optimal concentration of a specific drug at its site of action for an appropriate duration.