bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased cardiac involvement in Fabry disease using blood-corrected native T1 mapping
Authors: Nickander Jannike , Cole Ben , Nordin Sabrina , Vijapurapu Ravi , Steeds Richard P. , Moon James C. , Kellman Peter , Ugander Martin , Kozor Rebecca 
Published: March 2023

AbstractFabry disease (FD) is a rare lysosomal storage disorder resulting in myocardial sphingolipid accumulation which is detectable by cardiovascular magnetic resonance as low native T1. However, myocardial T1 contains signal from intramyocardial blood which affects variability and consequently measurement precision and accuracy. Correction of myocardial T1 by blood T1 increases precision. We therefore deployed a multicenter study of FD patients (n = 218) and healthy controls (n = 117) to investigate if blood-correction of myocardial native T1 increases the number of FD patients with low T1, and thus reclassifies FD patients as having cardiac involvement. Cardiac involvement was defined as a native T1 value 2 standard deviations below site-specific means in healthy controls for both corrected and uncorrected measures. Overall low T1 was 135/218 (62%) uncorrected vs. 145/218 (67%) corrected (p = 0.02). With blood-correction, 13/83 previously normal patients were reclassified to low T1. This reclassification appears clinically relevant as 6/13 (46%) of reclassified had focal late gadolinium enhancement or left ventricular hypertrophy as signs of cardiac involvement. Blood-correction of myocardial native T1 increases the proportion of FD subjects with low myocardial T1, with blood-corrected results tracking other markers of cardiac involvement. Blood-correction may potentially offer earlier detection and therapy initiation, but merits further prospective studies.
Lithium and brine geochemistry in the Qianjiang Formation of the Jianghan Basin, central China
Authors: Yu Xiaocan , Wang Chunlian , Huang Hua , Wang Jiuyi , Yan Kai 
Published: March 2023

AbstractThe Li-enriched oilfield brine is a very important lithium resource. It has gained much attention and become the target of active Li surveys with the growing global demand for Li. However, only little is known about their feature and nature. In the study, hydrochemical data from 155 oil wells tapping the Eocene to Lower Oligocene Qianjiang Formation of the Jianghan Basin, central China indicate that the brines are of the Na–Cl or Na–Ca–Cl type and are characterized by highly variable Li contents of 7.56 to 150 mg/L, with Mg/Li ratios less than 11.65. High Na/Cl and Cl/Br molar ratios indicate distinct contributions from halite dissolution. The Ca excess, Na deficit and Ca/Mg and Ca/Sr molar ratios in the brines imply multiple diagenetic processes, including halite dissolution, dolomitization, albitization and calcite or anhydrite cementation. The lithium contents of these brines have a weak relationship with the salinity and a negative correlation with Cl/Br ratios, possibly indicating that these Qianjiang oilfield brines have been diluted by secondary brines derived from halite dissolution. The spatial distribution patterns for Li and B concentrations of the brines are different from those for salinity and Br contents and show a geographic pattern, indicating that Li enrichment in the Qianjiang brines is likely connected with geothermal sources associated with volcanic activity.
Air-conditioning adoption and electricity demand highlight climate change mitigation–adaptation tradeoffs
Authors: Colelli Francesco Pietro , Wing Ian Sue , Cian Enrica De 
Published: March 2023

AbstractWe elucidate mid-century climate change impacts on electricity demand accounting for endogenous adoption of residential air-conditioning (AC) in affluent, cooler countries in Europe, and in poorer, hotter states in India. By 2050, in a high-warming scenario (SSP585) AC prevalence grows twofold in Europe and fourfold in India, reaching around 40% in both regions. We document a mitigation-adaptation tradeoff: AC expansion reduces daily heat exposures by 150 million and 3.8 billion person degree-days (PDDs), but increases annual electricity demand by 34 TWh and 168 TWh in Europe and India, respectively (corresponding to 2% and 15% of today’s consumption). The increase in adoption and use of AC would result in an additional 130 MMTCO2, of which 120 MMTCO2 in India alone, if the additional electricity generated were produced with today’s power mix. The tradeoff varies geographically and across income groups: a one PDD reduction in heat exposure in Europe versus India necessitates five times more electricity (0.53 kWh vs 0.1 kWh) and two times more emissions (0.16 kgCO$$_2$$

2

vs 0.09 kgCO$$_2$$

2

), on average. The decomposition of demand drivers offers important insights on how such tradeoff can be moderated through policies promoting technology-based and behavioral-based adaptation strategies.
Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
Authors: John Joyce , Clark Alys R. , Kumar Haribalan , Vandal Alain C. , Burrowes Kelly S. , Wilsher Margaret L. , Milne David G. , Bartholmai Brian , Levin David L. , Karwoski Ronald , Tawhai Merryn H. 
Published: March 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume (PVV) has been found to be an independent predictor of mortality in IPF and other interstitial lung diseases, however its estimation can be impacted by artefacts associated with image segmentation methods and can be confounded by adjacent fibrosis. This study compares PVV in IPF patients (N = 21) with PVV from a healthy cohort aged > 50 years (N = 59). The analysis includes a connected graph-based approach that aims to minimise artefacts contributing to calculation of PVV. We show that despite a relatively low extent of fibrosis in the IPF cohort (20% of the lung volume), PVV is 2–3 times higher than in controls. This suggests that a standardised method to calculate PVV that accounts for tree connectivity could provide a promising tool to provide early diagnostic or prognostic information in IPF patients and other interstitial lung disease.
High-performance surface plasmon resonance fiber sensor based on cylindrical vector modes
Authors: Sharif Vahid , Pakarzadeh Hassan 
Published: March 2023

AbstractCylindrical vector modes with azimuthal polarization and low transmission loss are proposed for the first time to be utilized in a novel design of a surface plasmon resonance (SPR) sensor based on a circular photonic crystal fiber (C-PCF). A C-PCF with a ring of air holes in the cladding is designed where a gold layer with a thickness of 44 nm is coated on the outer cladding surface. The optimal geometric parameters are determined using the finite-element method (FEM) for a high-quality TE01 mode and high sensitivity of the sensor. The proposed SPR sensor shows high sensitivity for analyte refractive index (RI) ranging from na = 1.29 to 1.34 over the wavelength range of 1400–2000 nm. It is expected that the proposed sensor can sense low concentrations of hemoglobin, lymphocytes and monocytes of red and white blood cells which are effective in diagnosing the progress of cancer tumors. The maximum sensitivity of 13,800 nm/RIU is obtained in the refractive index environment of 1.33–1.34. The sensor resolution is of the order of 10−6 and the amplitude sensitivity reaches its maximum of 2380 RIU−1 at na = 1.30 which is the highest value ever reported. Our proposed sensor shows high sensitivity and simultaneously simple design with high performance.
Safety and effect of pipeline flex embolization device for complex unruptured intracranial aneurysms
Authors: Chen Shun-Qiang , Li Li , Gao Bu-Lang , Wu Qiao-Wei , Shao Qiu-Ji , Wang Zi-Liang , Zhang Kun , Li Tian-Xiao 
Published: March 2023

AbstractTo investigate the safety and short-term effect of Pipeline Flex devices in the treatment of complex unruptured intracranial aneurysms, a retrospective study was performed for patients with complex unruptured intracranial aneurysms who were treated with the Pipeline Flex embolization device (PED Flex device) combined with or without coiling. The clinical, endovascular, and follow-up data were analyzed. One hundred and thirty-one patients with 159 complex unruptured cerebral aneurysms were treated with the PED Flex device, with 144 Flex devices deployed. Periprocedural complications occurred in four patients, resulting in the complication rate of 3.1%, including ischemic complications in three patients (2.3%) and hemorrhagic complication in one (0.8%). At discharge, the mRS was 0 in 101 (77.1%) patients, 1 in 25 (19.1%), 2 in four (3.1%), and 4 in one (0.8%), with the good prognosis rate (mRS 0–2) of 99.2%. Clinical follow-up was carried out in 87 (66.4%) patients 3–42 months after the procedure, with the mRS of 0 in 78 (89.7%), 1 in five (5.7%), 2 in three (3.4%), and 4 in one (1.1%). No significant (P = 0.16) difference existed in the mRS at discharge compared with that at clinical follow-up. Angiographic follow-up was performed in 61 (46.7%) patients with 80 (50.3%) aneurysms at 3–40 months, with the OKM grade of D in 57 (71.3%) aneurysms, C in eight (10%), and B in 15 (18.8%). Asymptomatic instent stenosis occurred in four patients (6.6%). In conclusion: The treatment of complex intracranial aneurysms with the Pipeline Flex embolization device may be safe and effective, with a high complete occlusion rate, a decreased complication rate, and a good prognosis rate at medium follow-up.
Photochemical advanced oxidative process treatment effect on the pesticide residues reduction and quality changes in dried red peppers
Authors: Bae Ji-Yeon , Lee Deuk-Yeong , Oh Kyeong-Yeol , Jeong Dong-Kyu , Lee Dong-Yeol , Kim Jin-Hyo 
Published: March 2023

AbstractPesticide residues in crops are widely monitored, and the residue reduction techniques at the post-harvest stage are important to maintain food safety. In dried crops, pesticide residues can be concentrated after dehydration, which increases concerns regarding residue risk. Therefore, the residue reduction effects of ultraviolet (UV), ozone, and photochemical advanced oxidative process (pAOP) were investigated for dried peppers at the post-harvest stage. UV254 treatment reduced 59.7% of the residue concentration on average, while UV360 showed a reduction of only 13.3% under 9.6 W m−2 of UV exposure for 24 h. Gaseous ozone treatments reduced the residue concentrations up to 57.9% on average. In contrast, the pAOP treatment reduced the concentration up to 97% and was superior to UV or ozone treatment alone. Increased drying temperature under pAOP condition resulted in higher reduction ratios at 40–80 °C. The pAOP conditions with 12 and 24 µmol/mol of ozone and UV254 irradiation for 24–48 h reduced the residue concentrations to 39–67%. Particularly, difenoconazole, fludioxonil, imidacloprid, and thiamethoxam residue concentrations were drastically reduced by over 50% under 12 µmol/mol ozone of the pAOP condition, while carbendazim, fluquinconazole, and pyrimethanil were relatively stable and their concentrations reduced below 50% under 24 µmol/mol ozone of the pAOP treatment. Various drying-related quality parameters of drying peppers such as water-soluble color, capsanthin, capsaicinoids, acid value, peroxide value, and thiobarbituric acid value were slightly altered, but not significantly, under 12 µmol/mol ozone of the pAOP condition, while the peroxide value was significantly altered under the higher ozone conditions. Therefore, pAOP treatment combined with gaseous ozone can be used for reducing residual pesticides in peppers without greatly reducing quality.
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
Authors: Ximerakis Methodios , Holton Kristina M. , Giadone Richard M. , Ozek Ceren , Saxena Monika , Santiago Samara , Adiconis Xian , Dionne Danielle , Nguyen Lan , Shah Kavya M. , Goldstein Jill M. , Gasperini Caterina , Gampierakis Ioannis A. , Lipnick Scott L. , Simmons Sean K. , Buchanan Sean M. , Wagers Amy J. , Regev Aviv , Levin Joshua Z. , Rubin Lee L. 
Published: March 2023

Abstract
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decline are modifiable or even reversible. To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains after parabiosis. For each cell type, we cataloged alterations in gene expression, molecular pathways, transcriptional networks, ligand–receptor interactions and senescence status. Our analyses identified gene signatures, demonstrating that heterochronic parabiosis regulates several hallmarks of aging in a cell-type-specific manner. Brain endothelial cells were found to be especially malleable to this intervention, exhibiting dynamic transcriptional changes that affect vascular structure and function. These findings suggest new strategies for slowing deterioration and driving regeneration in the aging brain through approaches that do not rely on disease-specific mechanisms or actions of individual circulating factors.
Deep reinforcement learning using least‐squares truncated temporal‐difference
Authors: Ren Junkai , Lan Yixing , Xu Xin , Zhang Yichuan , Fang Qiang , Zeng Yujun 
Published: March 2023

AbstractPolicy evaluation (PE) is a critical sub‐problem in reinforcement learning, which estimates the value function for a given policy and can be used for policy improvement. However, there still exist some limitations in current PE methods, such as low sample efficiency and local convergence, especially on complex tasks. In this study, a novel PE algorithm called Least‐Squares Truncated Temporal‐Difference learning (LST2D) is proposed. In LST2D, an adaptive truncation mechanism is designed, which effectively takes advantage of the fast convergence property of Least‐Squares Temporal Difference learning and the asymptotic convergence property of Temporal Difference learning (TD). Then, two feature pre‐training methods are utilised to improve the approximation ability of LST2D. Furthermore, an Actor‐Critic algorithm based on LST2D and pre‐trained feature representations (ACLPF) is proposed, where LST2D is integrated into the critic network to improve learning‐prediction efficiency. Comprehensive simulation studies were conducted on four robotic tasks, and the corresponding results illustrate the effectiveness of LST2D. The proposed ACLPF algorithm outperformed DQN, ACER and PPO in terms of sample efficiency and stability, which demonstrated that LST2D can be applied to online learning control problems by incorporating it into the actor‐critic architecture.
A novel air core electromagnetic fault current limiter with rotational motion
Authors: Fazljoo Seyed Amin , Aliabad Aliakbar Damaki , Amiri Ebrahim 
Published: March 2023

AbstractThe authors deal with design and analysis of an air‐core electromagnetic fault current limiter (FCL) with rotary motion. The proposed device is characterised by a simple structure, fast operating speed and reversible operation. It consists of two movable concentric air core spherical reactor rings (i.e. inner and outer rings) with variable mutual angular displacement. At normal condition, reactors are approximately aligned, and subsequently, the effective inductance/impedance of the equipment and the respective voltage drop are low. At faulty conditions, the short circuit current exerts a repulsive rotary electromagnetic torque on the reactors, which results in a fast and steady increase of the reactors angular displacement. During this process, the effective inductance of the equipment rapidly rises up to a level that effectively limits the short circuit current. To determine the effectiveness of the proposed topology in limiting the network's fault current, the inductance profile of the proposed rotary FCL and the respective fault current characteristic are compared with similar case studies (a) with linear FCL and (b) without FCL. The analysis is carried out via a finite element (FE) and supported via analytical and theoretical discussion. Finally, a down‐scale prototype of the proposed FCL was built and tested to verify the functionality of the device in the lab environment.
AGEs RAGE Pathways: Alzheimer’s Disease
Authors: Maheshwari Shubhrat 
Published: March 2023

AbstractNeurofibrillary tangles and plaques containing tau serve as the biological
markers for Alzheimer disease (AD) and pathogenesis is widely believed to be
driven by the production and deposition of the β-amyloid peptide
(Aβ). The β-amyloid peptide (Aβ) that results from the
modification of the amyloid precursor protein (APP) by builds up as amyloid
deposits in neuronal cells. Thus, a protein misfolding process is involved in
the production of amyloid. In a native, aqueous buffer, amyloid fibrils are
usually exceedingly stable and nearly insoluble. Although amyloid is essentially
a foreign substance made of self-proteins, the immune system has difficulty
identifying and eliminating it as such for unknown reasons. While the amyloidal
deposit may have a direct role in the disease mechanism in some disease states
involving amyloidal deposition, this is not always the case. Current research
has shown that PS1 (presenilin 1) and BACE (beta-site APP-cleaving enzyme) have
– and -secretase activity that increases β-amyloid peptide
(Aβ). Wealth of data has shown that oxidative stress and AD are closely
connected that causes the death of neuronal cells by producing reactive oxygen
species (ROS). Additionally, it has been demonstrated that advanced glycation
end products (AGEs) and β-amyloidal peptide (Aβ) together
increase neurotoxicity. The objective of this review is to compile the most
recent and intriguing data of AGEs and receptor for advanced glycation end
products (RAGE) pathways which are responsible for AD.
Usefulness of Free Tissue Transfer for the Reconstruction of Extensive Thigh Defects
Authors: Choi Jae-Min , Lee Kyeong-Tae , Mun Goo-Hyun 
Published: March 2023

Abstract
Background Despite the increasing popularity of free tissue transfer, thigh defects have been alienated from their potential indication, owing to the abundance of regional reconstruction options. However, some challenging situations where locoregional modalities may lead to suboptimal outcomes often require free flap. Due to lacking studies regarding microvascular reconstruction of thigh defects, this study aimed to investigate the versatility of free tissue transfer for reconstruction of thigh defects.
Methods A retrospective review was performed for patients who underwent microvascular reconstruction of thigh defects between 2003 and 2021. Their demographics and operation-related data were summarized and postoperative outcomes were evaluated.
Results Sixty-five patients were analyzed, with a median follow-up period of 15.5 months. Most common situations requiring free tissue transfer were extensive defects, followed by large dead space with exposure of major neurovascular bundle and chronic wounds surrounded by unhealthy regional tissue. Defects were most frequently located in the anterior compartment horizontally and in the distal thigh vertically. The median surface area of the defects was 180.0 cm2. The latissimus dorsi musculocutaneous and thoracodorsal artery perforator flaps were the two most commonly used flaps. Reliable recipient vessels could generally be easily found in the vicinity of defects. Overall complications developed in 12 cases (18.5%), including two of partial flap necrosis. No total flap loss was encountered.
Conclusion Free tissue transfer could provide reliable outcomes and facilitate rapid recovery, and could be actively considered for reconstruction of thigh defects in situations unfavorable to the locoregional option.
Cluster Preface: Chemical Synthesis and Catalysis in India
Authors: Maiti Debabrata , Mukherjee Santanu 
Published: March 2023

Debabrata Maiti (left) received his Ph.D. from Johns Hopkins University in 2008 under the supervision of Prof. Kenneth D. Karlin. After postdoctoral studies at MIT with Prof. Stephen L. Buchwald, he joined the Department of Chemistry at IIT Bombay in 2011. His research interests are focused on the development of new and sustainable synthetic and catalytic methodologies. He is currently an Associate Editor of the ­Journal of Organic Chemistry.
Santanu Mukherjee (right) obtained his Ph.D. in 2006, working under the supervision of Prof. Albrecht Berkessel at the Universität zu Köln, Germany. He subsequently worked as a postdoctoral fellow with Prof. Benjamin List at the Max-Planck Institut für Kohlenforschung, and with Prof. E. J. Corey at Harvard University. In 2010, he joined the Department of Organic Chemistry at IISc Bangalore. His research interests revolve around various aspects of asymmetric catalysis, with particular emphasis on organocatalytic enantioselective desymmetrization and transition-metal-catalyzed enantioselective allylic, allenylic and propargylic substitution reactions. He is an Associate Editor of Organic & ­Biomolecular Chemistry.
Effectiveness of Planned Early Ambulation on Postoperative Recovery among Cesarean Mothers: A Quasi-experimental study in Mangaluru
Authors: Alphones Carol Karishma , Miranda Janet Prima 
Published: March 2023

Abstract
Background Mothers with cesarean section need more attention and care. Early ambulation is the essential to restore the maximum muscle function and improve the health during postoperative period. Early ambulation certainly has proven to be effective in preventing postoperative complications.
Aim To evaluate the effectiveness of early ambulation on postoperative recovery among cesarean mothers.
Methods Nonprobability purposive sampling technique was used to select 60 cesarean mothers, with 30 samples in each of the experimental and control group. Mothers in the intervention group received bed exercises by the investigator such as flexion and extension of the extremities, upper limb exercises, lower limb exercise, turning the patient, sitting with dangling the feet, and deep breathing exercises which was initiated at 10 hours of cesarean section followed by standing and walking at 12 hours of cesarean section for twice a day, whereas the control group received routine treatment as per the hospital protocol. Demographic proforma was used to assess the demographic characteristics, and structured postoperative recovery assessment tool was used to assess four major components such as pain, breast feeding, postnatal changes, and activity of daily living. The obtained data were analyzed using descriptive and inferential statistics.
Statistical Analysis Significant difference in the postoperative recovery score was calculated by using RM-ANOVA and independent t-test and the association of postoperative recovery score with selected demographic variables done by chi-square test.Results The majority of mothers in intervention (66.7%) and control group (63.3%) were 24 to 29 years old and had secondary education (60% each). There was significant difference in breast feeding (p = 0.001), involution of uterus (p = 0.047), amount of lochia (p = 0.027), and activity of daily living in the intervention group (p < 0.05) compared with the control group.
Conclusion Early ambulation improves the postoperative recovery and helps to achieve a good sense of well-being.