bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clinical Profile and Long-Term Outcome of Children with Membranous Nephropathy, and the Evaluation of Anti-Phospholipase A2 Receptor Antibody Immunohistochemistry in Kidney Biopsy
Authors: Deepthi RV , George Sachin , Mathew Georgie , Roy Sanjeet , Bindra Mandeep , Rebekah Grace , Agarwal Indira 
Published: May 2023

Abstract

Introduction:
Idiopathic membranous nephropathy (iMN) is a rare cause of nephrotic syndrome in children (1%–7%). Anti-phospholipase A2 receptor (PLA2R) antibody positivity in kidney biopsy is observed in 52%–78% of adults and 45% of children with iMN. The objectives of the study are to analyze the clinical profile and outcome of membranous nephropathy in children, to assess the prevalence of anti-PLA2R immunohistochemistry (IHC) in kidney biopsy, and to correlate their presence with disease characteristics.

Methods:
We are reporting a single-center retrospective study conducted in pediatric nephrology division. Clinical data and outcome parameters of children with membranous nephropathy were analyzed. PLA2R IHC was performed in kidney biopsy specimens retrospectively.

Results:
We analyzed 43 children with membranous nephropathy (MN) from a single center. 18 (42%) had idiopathic MN (iMN). PLA2R IHC was performed in kidney biopsy specimens in 14/18 (78%) patients with iMN and 7/9 (78%) non-lupus secondary membranous nephropathy (SMN) patients. The most common cause of SMN was lupus nephritis in 16 patients (64%). The mean estimated glomerular filtration rate (eGFR) at onset was 156 ± 81 ml/min/1.73m2. The sensitivity and specificity of PLA2R IHC in diagnosing pediatric MN was 50% and 57%, respectively; positive and negative predictive values were 70% and 36%, respectively. At the final follow-up, chronic kidney disease stage 5 (CKD 5) developed in 2/14 (14.3%) iMN patients.

Conclusions:
IHC PLA2R staining of glomerular tissue is a useful diagnostic marker of IMN. Though PLA2R prevalence is lower in children, its role in guiding treatment needs further exploration.
Phenotype Spectrum in Tunisian Population with NPHP1 Deletion
Authors: Hammi Yousra , Ferjani Maryem , Meddeb Rym , Kacem Rania , Sayari Taha , Mrad Ridha , Gargah Tahar 
Published: May 2023

Abstract

Introduction:
Nephronophthisis (NPHP) is a tubulointerstitial kidney disorder with an autosomal recessive inheritance pattern. Its genetic heterogeneity contributes to phenotype variability. The most frequent etiology of juvenile nephronophthisis is a mutation in the nephronophthisis type 1 (NPHP1) gene. This study aimed to evaluate the genotype-phenotype correlation in NPHP1 gene mutation.

Methods:
A multicenter retrospective study was performed over 20 years from 1998 to 2018 to describe the clinical, biological, and radiological features associated with the large deletion NPHP1 gene in 32 patients.

Results:
The incidence of NPHP1 was 1.6/204041. Eighty-one percent of our patients were born out of consanguineous marriages. The mean age at diagnosis was 14 ± 7 years. The patients were divided into three groups: isolated nephronophthisis (72%), syndromic nephronophthisis (19%), and patients without recognizable syndrome (9%). Intrafamilial and geographical variability was observed in syndrome diagnoses and in age at the onset of CKD stage 5. Genotype frequency varied between 50% and 100% in genealogical data. Juvenile (47%), adolescent (37%), and adult (13%) clinical forms have been distinguished by the onset of CKD stage 5. The five-year survival rate of renal transplantation was 80%.

Conclusion:
Given the broad clinical spectrum of NPHP1 associated with the large deletion of the NPHP1 gene, no genotype-phenotype correlation could be established.
Sinonasal teratocarcinosarcoma in an adolescent male: A case report of an unusual neoplasm
Authors: Soman Aashna , Prasad P. H. , Ajayan P. V. 
Published: May 2023

ABSTRACT
Sinonasal teratocarcinosarcoma (SNTCS) is an extremely rare and aggressive malignant tumor arising in the sinonasal tract, having a combined clinicopathological feature of teratoma and carcinosarcoma. It shows a male predominance and affects adults with an age range of 18–79 years and a mean age of 60 years. Here, we report a case of SNTCS in a 14-year-old male patient who presented with swelling over the upper right alveolus and pain in the right jaw for 2 months. The tumor was completely removed by right total maxillectomy with orbital mess reconstruction, and postoperative radiotherapy with chemotherapy was given. The follow-up of the patient for 2 years has shown evidence of recurrence and is now on palliative care.
“Efficacy of cytotoxic effect of green tea catechins on the human periodontal fibroblasts and human dental pulp fibroblasts -An in vitro study”
Authors: Hattarki Sanjeevini , Bogar Chetana , Bhat Kishore 
Published: May 2023

Background:
Inflammation of tooth-supporting tissue and the pulp tissue is followed by wound healing and regeneration process that involves the specific type of connective tissue cells, the fibroblasts. During periodontitis and pulpitis, the inflammation of the tissue causes damage to the fibroblasts. These fibroblasts secrete collagen proteins and maintain the structural framework; along with this the inflammatory process moves toward healing where in the specific cells such as the fibroblast cells play important roles. Green tea catechins epigallocatechin-3-gallate (EGCG) being one of the major catechins is known to have multiple beneficial effects on human fibroblasts.

Objective:
To assess the in vitro cytotoxicity of green tea catechins on the human periodontal ligament (PDL) fibroblasts and human dental pulp fibroblasts.

Materials and Methods:
Human PDL fibroblasts (hPDLFs) and human dental pulp fibroblasts were isolated from the two extracted premolar teeth that were indicated for orthodontic treatment. The fibroblasts were then seeded in 96 well tissue culture plate for cell viability study. EGCG was used at different concentration to treat the cells. After 48 h; (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) (MTT) assay was performed to determine the cell viability.

Results:
The vitality of hPDLFs and human dental pulp fibroblasts was found to be inversely proportional to EGCG concentrations.

Conclusions:
hPDLFs have shown 37% proliferation at lowest concentration of EGCG used and human dental pulp fibroblasts have shown 99% viability at lowest concentration of EGCG used.
Estimation of vestibular depth: An observational cross-sectional study
Authors: Nandkeoliar Tanya , Kumar Ashish , Chungkham Sachidananda , Singh Sinam Subhaschandra 
Published: May 2023

Background:
The vestibular depth (VD) varies to a great extent among individuals and at different points of reference. The normal range of depth of the vestibule at different areas in the mouth remains to be established.

Aim:
The primary objective of this study is to assess the average VD around different teeth in the maxilla and the mandible. Furthermore, an attempt has been made to identify the various ranges of VD and understand what could be suggestive of a normal VD.

Materials and Methods:
The participants included were divided into four age groups, i.e., 6–14 years (Group 1), 15–30 years (Group 2), 31–50 years (Group 3), and >50 years (Group 4). Further, the subjects were grouped into subgroup A, periodontally healthy and subgroup B, gingival recession (GR). Group 1, 2, and 3 included 30 subjects each in subgroup A, while Group 4 subgroup B had 18 subjects. In case of subgroup B, Group 2 included 9 subjects, Group 3–31 subjects, and Group 4–30 subjects. Measurements included the depth of vestibule from 2 reference point, i.e., gingival margin (GM) and incisal edge (IE).

Results:
In subgroup A, the average VD from GM was found to be the least in the Group 1 i.e., 6–14 years (9.2 mm ± 4.26 in maxilla and 7.01 mm ± 3.14 in the mandible) and the highest in the Group 4 i.e., >50 years (12.06 mm ± 2.73 in maxilla and 10.08 mm ± 2.58 in the mandible). In the case of subgroup B, the least depth from GM was found in the Group 3 i.e., >30–50 years (9.44 mm ± 2.73 in the maxilla and 8.32 mm ± 1.7 in the mandible) and the maximum depth in the Group 4 (>50 years) (11.28 ± 2.31 in maxilla and 9.42 ± 2.87 in the mandible).

Conclusion:
The study provides a range of VD s in different areas of the mouth in periodontally healthy and individuals with GR, which will contribute to constitute a normal range of VD.
Effects of nonsurgical periodontal therapy on serum creatinine level in systemically healthy individuals with periodontitis: An interventional study
Authors: Bagchi Suchi Suvra , Muthuraj Thamil Selvan , Sarkar Puja , Bandyopadhyay Prasanta , Ghosh Papita 
Published: May 2023

Background:
Several studies have suggested a relationship between periodontitis and serum creatinine levels. Both low and high serum creatinine levels have been reported in individuals with periodontitis. The impact of periodontal therapy on serum creatinine levels has not been fully investigated yet. The aim of the study is to estimate the influence of nonsurgical periodontal therapy (NSPT) on serum creatinine levels in systemically healthy individuals with periodontitis at stage II and stage III with grade A and grade B.

Materials and Methods:
Sixty-eight systemically healthy individuals included in the study were divided into Group A (GA) (Periodontally healthy) and Group B (GB) (Periodontitis: stage II and III with grade A and grade B). Gingival index, sulcular bleeding index, probing pocket depth, clinical attachment level, body mass index, and serum creatinine levels were recorded at baseline for both GA and GB, 90 days after NSPT for GB only. Collected data were analyzed statistically.

Results:
Serum creatinine levels in GB were significantly higher when compared with GA and serum creatinine levels in GB before and 90 days after NSPT were statistically insignificant.

Conclusions:
Serum creatinine levels were higher in individuals with periodontitis when compared with periodontally healthy individuals and NSPT has no considerable influence on the serum creatinine levels in individuals with periodontitis. Further studies are required to confirm these findings.
Effect of ozone irrigation and powered toothbrushing on dental plaque, gingival inflammation, and microbial status in institutionalized mentally challenged individuals: A double-blinded, randomized, controlled clinical trial
Authors: Tatuskar Pramod Vinayak , Karmakar Shaswata , Walavalkar Narayan Narendra , Vandana Kharidhi Laxman 
Published: May 2023

Aim:
This study compares and evaluates the efficacy of ozonated water irrigation (OZI) and powered toothbrushing on the oral health and microbial status of mentally challenged individuals.

Materials and Methods:
Thirty individuals of age range 15–30 years with a mild-to-moderate level of mental retardation (MR) and gingival inflammation participated in this double-blind randomized controlled clinical trial. Total duration of the study was 45 days consisting of two clinical phases (phase I, i.e., aided) and phase II, i.e. unaided) of the duration of 21 days in each phase, with a washout period of 3 days between the two phases. With a split-mouth design, sites from each subject were randomly allocated into two treatment groups: Powered Toothbrushing (PB) and OZI were randomly done for each half side of the mouth of each subject. Subgingival plaque samples were collected from sites of both the treatment groups and sent for microbial analysis. Clinical and microbial parameters were measured before and after the treatment.

Results:
Significant improvement of the clinical and microbial parameters was found in both treatment groups. However, intergroup differences in the parameters were statistically nonsignificant.

Conclusion:
OZI could serve as an alternative or adjunct to powered toothbrushes for people with MR.
Implementation of Continuous-Assessment on Postgraduate Program
Authors: Wasis Wasis , Sunarti Titin , Jauhariyah Mukhayyarotin Niswati Rodliyatul 
Published: May 2023

Objective: The assessment approach is crucial to achieving learning outcomes. Contonuous-Assessment (CA) is one alternative assessment that can be used to increase various skills. This preliminary study aims to: (1) formulate CA and project-based assessment in higher education; (2) describe the lecturer's and students' perception of CA in the postgraduate program; (3) map course assignments within the framework of CA at the postgraduate level. Method: Data was collected through Forum Group Discussions (FGDs) and questionnaires. Data were analyzed both qualitatively and quantitatively. Results: The results show that the conceptual study of the CA should pay attention to the purposes, improve the learning process, involve students fully and purposefully in their learning, and explore the factors that influence the learning process. The design of CA is realized as demand mapping for each course in the form of products or small projects as part of the stages for completing a thesis/dissertation. Most lecturers and students agree that the lecture process uses a CA design in which each course contributes to achieving the thesis/dissertation. A small number of them disagree and give some suggestions. Novelty: The novelty of this research is to produce a mapping of assignments from all courses, which leads to the completion of writing a thesis/dissertation.
Analysis of Critical Thinking Skills of Prospective Elementary School Teacher Student
Authors: Julianto Julianto , Wiryanto Wiryanto , Suprayitno Suprayitno , Susetyo R Asri , Hidayati Fitria , Rahmawati Endah 
Published: May 2023

Objective: Education is one of the basic needs of humans. The current educational challenge is to produce individuals who can compete in the 21st century. We can access various information freely via the internet, and there is no guarantee that the news we see is true. To use this information properly, individuals must evaluate data and information sources. Method: The type of research used is qualitative research. The population in this study is all ESTE FoE Unesa students, and the sample used is the 2018-2020 class. The sample used was class 2019, D, and F, totaling 84 students. The data collection method used in this study is the test. The instrument used in this study was a critical thinking skills test. Data analysis was carried out in percentage terms. Results: The results showed that the critical thinking skills of Elementary School Teacher Education Faculty of Education Unesa students were in a low category. The results of this study are expected to be used by lecturers or researchers to design and develop learning activities that can facilitate students to practice critical thinking skills. Novelty: Lecturers can design the implementation of learning in the classroom that trains critical thinking skills to become more qualified, effective, and efficient.
Analysis of Early Childhood Fine Motor Skills Through the Application of Learning Media
Authors: Rosalianisa Resi , Purwoko Budi , Nurchayati Nurchayati 
Published: May 2023

Objective: The learning media is one of the methods needed in the learning process when students are in class, especially for developing fine motor skills. Fine motor skills are fine motor skills that involve finely coordinated movements. This research was conducted to describe and analyze the implementation of the learning media to develop and stimulate the development of children's fine motor skills. The novelty of the research is learning media to improve fine motor skills in early childhood. This study aims to describe fine motor skills in early childhood through learning media. Method: This research method is a literature study or literature review with a qualitative approach that is carried out by collecting data or based on scientific writing, which combines research with existing literature to solve existing problems—collecting data on library materials by reading and storing and managing research materials and concluding research materials. Results: Based on an analysis of 30 learning articles using learning media shows that developing fine motor skills in early childhood requires learning activities using learning media to support and support the learning process. In addition, when the learning process uses learning media, children become interested, enthusiastic, and excited because learning activities become fun. Novelty: The novelty of the research is learning media to improve fine motor skills in early childhood.
Analysis of Effectiveness PBL-STEM to Improve Student’s Critical Thinking Skills
Authors: Wahdaniyah Noera , Agustini Rudiana , Tukiran Tukiran 
Published: May 2023

Objective: This study aims to analyze the effectiveness of PBL-STEM in improving students' critical thinking skills. Method: The method used in this research is the literature review method. A literature review is a type of research that collects data and information from various sources by collecting and analyzing. This study analyzes as many as two national and international articles that can be accounted for. The articles used were published in 2018-2022. The steps in this Literature review method are identifying topics, searching for and selecting relevant articles, analyzing and synthesizing the literature, and creating a conclusion. Results: (1) the application of the PBL model can improve students' critical thinking skills; (2) the integration of STEM in the learning process is also able to improve critical thinking skills because STEM provides opportunities for students to identify real-life problems and solve them, which is per the characteristics of PBL; (3) the integration between PBL and STEM can be applied and can provide more effective results in improving students' critical thinking skills. Novelty: ThisThis study discusses the analysis of how effective the integration of STEM and PBL from the latest journals so that this research can be used as a reference for making quality learning tools.
Analysis of Effectiveness Argument-Driven Inquiry to Improve Students’ Argumentation Skill and Conceptual Understanding
Authors: Kuki Agustina Dua , Agustini Rudiana , Azizah Utiya 
Published: May 2023

Objective: This study examined the effectiveness of the Argument-Driven Inquiry learning model in science learning in improving students' argumentation skills and conceptual understanding. Method: The techniques used are 1) searching articles on Scopus and Google Scholar using the keyword Argument-Driven Inquiry in science learning, 2) articles were selected focus on increasing conceptual understanding and argumentation skills, 3) the metadata was selected limited to 2015-2023, and 4) conducting the in-depth review. Results: The ADI model was able to improve students' argumentation skills. In general, students' argumentation levels are in levels 3-4. The quality of the arguments developed by students shows the understanding of the concepts possessed by students. Students can reach the cognitive level created (C6) by writing scientific reports. Novelty: This study reinforces previous research regarding the effectiveness of the ADI model in improving argumentation skills and conceptual understanding taken from recent articles. Therefore, this article can be the basis for developing learning tools for the ADI model.
Utilization of Universities’ Massive Online Open Courses in Learning Management System: Research Trends and Bibliometric Analysis
Authors: Dwikoranto Dwikoranto , Surasmi Wuwuh Asrining , Kurniawan Benny , Dawana Irgy Redityo , Bergsma Lindsay N. 
Published: May 2023

Objective: This study aims to explore research trends related to the use of Massive Open Online Courses in Learning Management Systems (MOOCs in LMS) in university environments and to conduct bibliometric analysis to understand research developments related to this topic. Online learning is increasingly popular with the MOOCs in LMS, which allows students to learn flexibly and independently through digital platforms. Method: The data is retrieved from the Google Scholar database, using keywords related to MOOCs in LMS and universities. This study uses a bibliometric analysis method using the Google Scholar and VOSviewer databases, which obtained 1,710 articles. Results: The results show that the use of MOOCs in LMS in the context of university learning has become an increasingly popular research topic in recent years, where the publication rate has increased significantly. This has the potential to be further investigated in the future. Further research related to MOOCs in LMS can be integrated with blended learning models. This is because the Blended learning model using MOOCs can improve critical thinking skills and problem-solving. This research has limitations, namely using only one database, Google Scholar, to obtain research data. Novelty: Therefore, it is recommended that MOOCs in LMS research at universities be carried out using other databases besides Google Scholar to obtain broader data.
Is Spending Nights Away From Home Associated With Participation and Life Satisfaction After Spinal Cord Injury? A Longitudinal Perspective
Authors: Cole Shu , Wang Zikun , Chen Zhongxue , Hua Chenggang , Chen Yuying , Evans Delaney 
Published: May 2023

Background
Community reintegration after SCI rehabilitation consists of readjustment not only to the home setting but also to the social and occupational spheres, which often require people to spend nights away from home. Because community reintegration contributes to life satisfaction after SCI, it is necessary to investigate how travel participation is related to occupational and social participation and life satisfaction. Additionally, better management of the long-term effects of SCI requires better understanding of the changes in participation and life satisfaction over time.

Objectives
To examine how participation and life satisfaction change over time following SCI, and to investigate whether spending nights away from home is associated with occupational and social participation and life satisfaction over time.

Methods
This is a longitudinal analysis of data extracted from the publicly available database of Spinal Cord Model Systems from 1996 to 2016. A generalized linear mixed model was developed to examine the changes of outcome variables over time while controlling demographic variables.

Results
Travel and social participation declined while life satisfaction increased as people lived longer with SCI, controlling for confounders. No significant change was identified in occupational participation. Spending nights away from home was significantly and positively associated with social and occupational participation and life satisfaction over time. Although travel participation of people with SCI declined over time, its association with social participation strengthened as the number of postinjury years increased.

Conclusion
Travel participation plays an important role in successful community reintegration. Rehabilitation services and travel services should provide training and resources on travel after SCI for improved participation and life satisfaction.