bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Future Performance of the Planned Seismic Network in Chinese Mainland
Authors: Li Jiawei , Mignan Arnaud , Sornette Didier , Feng Yu 
Published: September 2023

Abstract
The China Earthquake Administration has currently launched an ambitious nationwide seismicity monitoring network project that will increase the number of stations from ∼950 to 2000 for the broadband seismic stations used to compile the earthquake catalog. The new network is planned to go online by the end of 2023. For more than half of Chinese mainland, the interstation distance of the broadband seismic network will soon be smaller than 100 km, for 27% smaller than 50 km, and for 6% smaller than 25 km. Of all possible ways to characterize the higher-resolution monitoring of the frequent smaller earthquakes expected inside Chinese mainland, the completeness magnitude (Mc) remains one of the most commonly used. Using the prior model of the Bayesian magnitude of completeness method calibrated on the Chinese earthquake catalog from 1 January 2009 to 26 June 2022, we predict the spatial distribution of Mc for the new network based on the planned network configuration. If almost the entire Chinese mainland is at present covered down to Mc=3.3, this threshold will fall to Mc=2.9 in the near future. This means approximately two times more earthquakes will be recorded in the complete catalog available for statistical analysis per year (for a = 6.77 and b = 0.80 in the Gutenberg–Richter law log10N=a−b·M, in which N represents the number of events of magnitude larger than or equal to M and M≥Mc). Based on the observation that abnormal seismicity as precursors are most likely to be observed at least at three units below the mainshock magnitude, and assuming earthquakes to be potentially damaging at M ≥ 5, the new seismic network shall achieve the goal of 76% coverage for optimal seismic-based earthquake prediction research.
Gaining Ground: OER at 3 Health Sciences Institutions
Authors: Kirschner Jessica , Monnin Jenn , Andresen Christine 
Published: September 2023

Background: Open Educational Resources (OER) are rising in popularity at higher education institutions to help combat high textbook costs. To date, little research has been published discussing the impact of OER in the health sciences context. This comparative case study seeks to fill this gap.
Experience: The article shares OER programs and advocacy efforts at three institutions, including a brief history of OER work, barriers and failures, current successes, and future directions at each institution.
Discussion: All three institutions are making efforts in OER outreach and advocacy, informed and impacted by their institutional community. Two institutions have an OER grant with increasing submissions from health sciences faculty. OER work is completed by one librarian at two of the institutions, while the third completes the work through a committee of stakeholders from across the institution. All cases include OER advocacy and outreach through library workshops and working to establish faculty partnerships. Barriers at all three institutions include a lack of time and funds to dedicate to finding or developing OER. Unique barriers include a desire to work with for-profit companies, concerns over disadvantaging students on their qualifying exams, and the sustainability of institutional efforts in OER.
Takeaways: Libraries are uniquely situated to support faculty and staff as they incorporate OER into their practices. While health sciences faculty are typically slower to adopt OER, once they do take this step, they become strong advocates for open practices, the librarian, and the library.
Gustave roussy immün skor operabl kolorektal kanserli hastalarda prognozu ve sağkalımı öngörebilir mi?
Authors: ONDER Arif Hakan , İLHAN Yusuf , BALÇIK Onur Yazdan , KARAKAYA Gökhan 
Published: September 2023

Amaç: Opere olan metastatik olmayan kolorektal kanserli hastalarda, tanı anında bakılan GRIm skorunun, nüks, prognoz ve sağkalım üzerine etkisinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: Çok merkezli retrospektif bir çalışma olarak planlanmış olup, toplam dört farklı merkezden veriler elde edildi. Kliniklerimizdeki hastalar 2010 yılı ile 2023 yılı tarihleri arasında tanı almış hastalardan oluşmaktadır. Gustave Roussy İmmün Skoru (GRIm-Score) belirlenmesi için hastaların operasyon öncesindeki nötrofil, lenfosit, nötrofil/lenfosit oranı (NLR) serum albümin (ALB) ve serum laktat dehidrogenaz (LDH) düzeyleri yanı sıra Kras, Braf mutasyon durumları ve CEA düzeyleri değerlendirildi. Hastalar GRIm skorlarına göre 0-1 düşük ve 2-3 yüksek olmak üzere iki gruba ayrıldı. Sonrasında hastalıksız sağkalım ve genel sağkalım analizleri yapıldı.
Bulgular: Çalışma popülasyonumuz tanıda metastatik olmayan, opere olmuş 405 kolorektal kanserli hastadan oluşmaktadır. Hastalar genel demografik verileri ve onkolojik özellikleri açısından GRIm skor düzeylerinin yüksek veya düşük olmasına göre gruplandırıldı. Yüksek GRIm-skor gurubuyla; yüksek N (Lenf Nodu) pozitifliği ve ileri TNM (T tümör boyutu, N lenf nodu ve M metastaz durumu) evresi, yüksek CEA düzeyi, RAS ve RAF mutasyonun varlığı, yüksek yaş ortalaması ve yüksek VKİ(>25) ile örtüşüyordu. Yapılan sağkalım analizlerinde kadın olmak (HR:0.53;%95CI: 0.33-0,85; p=0.010) ölüm riskini azaltırken, GRIm skorunu yüksek olması (HR:1.86;%95CI: 1.06-3.26; p=0.030) ve RAS mutasyonun olması ise (HR:2.01;%95CI: 1.14-3.54; p=0.016) ölüm riskini arttırdığı bulundu. Hastalıksız sağkalım açısından da benzer analiz yapıldığında ise CEA’nın 5 ng/ml ve üstü olması (HR:1.98;%95CI: 1.09-3,60; p=0.025), RAS mutasyonun olması (HR:2.41;%95CI: 1.56-3.74; p
Validation of the Turkish version of the pediatric early warning score
Authors: AKDENİZ Sevda , SELÇUK KUŞDERCİ Hatice , CANİKLİ ADIGÜZEL Şenay , OZBUDAK Pınar , DOGRU Serkan , AKDENİZ Ekrem , BAŞARANOĞLU Gökçen , SÜREN Mustafa 
Published: September 2023

Aim: The pediatric early warning score (PEWS) identifies pediatric patients at risk for clinical deterioration and can helpless-experienced providers get a sense of which patients may need escalation of care. The purpose of the study was to adapt the PEWS into Turkish and evaluate its validity in pediatric patients admitted to the emergency.
Material and Methods: This study was conducted between May and October 2022 on 228 patients aged 17 and under in the pediatric emergency department of a tertiary care hospital. In the pilot phase of the study, scoring of the first 30 patients was performed by three nurses in the emergency department. In the second phase, the validity of the PEWS scale was evaluated. Validity of the scoring system in predicting admission was assessed using area under the receiver operating characteristics (ROC) curve (AUC), sensitivity, and specificity, positive predictive value (PPV) and negative predictive value (NPV).
Results: The mean age of the children was 6.37 ± 4.72 years. Phase I demonstrated good inter-rater reliability (kappa = 0.75). In phase II, 22 patients (9.6%) were admitted to the intensive care unit (ICU) during the study period. AUC for predicting was 0.948 (95% CI: 0.915–0.981). According to ROC curve analysis, a cut-off value for PEWS score was found to be 4 (PEWS >4) for admitted to the ICU. Sensitivity and specificity in predicting ICU admission with the cut-off PEWS ≥4 was 86.36% and 90.78%, respectively (PPV, 50%; NPV, 90.48%). The sensitivity and specificity in predicting admission with a cut-off of PEWS ≥1 was 100% and 59.22%, respectively (PPV, 20.75%; NPV, 100%).
Conclusion: The Turkish version of PEWS can be helpful in assessing patient status in pediatric emergency department with acceptable validity and can serve as a potentially screening tool for prediction of ICU admission.
Toleransi dan Politik Identitas: Studi tentang Perilaku Politik Kebangsaan di Indonesia
Authors: Romadhon Sukron , Try Subakti  
Published: September 2023

Toleransi sebagai sikap memberi kesempatan kepada orang lain untuk menyampaikan pendapatnya, tanpa melakukan penilaian bahwa pendapat yang disampaikan salah atau benar, sama atau berbeda. Penghormatan dan ketaatan kepada sistem hukum, bersatunya setiap elemen yang berbeda dalam berbagai hal yang berkaitan dengan budaya, nilai, norma atau agama ke dalam sistem politik. Politik identitas hadir sebagai konstruksi masyarakat dalam menentukan posisi atas kepentingan suatu komunitas politik. Penelitian ini mengunakan pendekatan kualitatif dengan sajian data berupa deskriptif dengan ketajaman dan analisis data tentang toleransi dan politik identitas; studi tentang perilaku politik kebangsaan di Indonesia. Jenis penelitian dengan menggunakan studi kasus yang bersifat analisis-deskriptif. Sumber data penelitian ini berupa data studi pustaka yang menggunakan data sekunder berupa dokumen, arsip, buku, artikel, dan jurnal, surat kabar. Hasil penelitian kepustakaan dan analisis menunjukkan bahwa politik identitas dipahami sebagai konstruksi dalam menentukan kepentingan kelompok tertentu, yang akan menjadi sarana mencapai politik kekuasaan; Tokoh masyarakat yang menjadi ikon tentang kriminalisasi politik nasional; Terciptanya politik yang dinamis tentu harus ada kontrol secara politik yang berimbang antara kubu koalisi versus oposisi; Sikap tegas Negara dalam menjaga stabilitas nasional dengan mencabut dan melarang ormas-ormas yang menimbulkan konflik social.
Kata Kunci: Toleransi, Politik Identitas, Perilaku Politik
Dinamika Perkembangan Demokrasi serta Problematikanya Pasca Reformasi
Authors: Siti Nurhayati  
Published: September 2023

Pasca reformasi 1998 mulai timbul kesadaran masyarakat agar pemerintah melangsungkan demokrasi berupa pemilihan umum dan Pilkada. Pemilihan umum dan Pilkada sebagai sarana menghilangkan praktik-praktik rekayasa, otoriter dan manipulatif yang menimbulkan ketidak adilan rakyat. Pemilu dan pilkada merupakan wujud demokrasi sehingga menghasilkan kedaulatan rakyat yang sesungguhnya. Pemilu dan Pilkada pasca reformasi dinilai sudah berjalan dengan baik, namun perlu ada peningkatan sistem maupun kualitas dari pemilu, dengan asas “LUBER JURDIL” (Langsung, Umum, Bebas, Rahasia, Jujur dan Adil). Pembahasan mengenai Undang- Undang mengenai pemilu dan pilkada sudah mempunyai aturan yang jelas yakni Undang-Undang mengenai pemilihan umum tertera pada UU Nomor 7 Tahun 2017 tentang Pemilihan Umum. Fase perjalanan demokrasi di Indonesia sudah mengalami banyak perubahan sekaligus perkembangan mulai dari demokrasi parlementer sampai pada demokrasi Pancasila Era Reformasi yang berjalan sampai saat ini. Di sisi lain, perkembangan dan dinamika demokrasi saat ini adalah memilih pemimpin negara atau daerah dengan sistem pemilihan secara langsung yang dinilai sebagai bukti nyata cerminan dari kedaulatan rakyat yang tercantum pada Pasal 1 Ayat 1 Undang-Undang Dasar Repubik Indonesia Tahun 1945. Maka dengan adanya proses demokrasi yakni berupa Pemilu dan Pilkada, rakyat bisa menyalurkan aspirasinya. Implementasi demokrasi dalam proses pemilihan umum masih mengalami beberapa permasalahan yang membutuhkan solusi. Upaya yang dapat dilakukan antara lain dengan peningkatan penguatan pendidikan politik bagi masyarakat, di mana setiap warga negara berhak untuk memilih dan dipilih dalam proses pemilihan umum. Penguatan ideologi Pancasila harus terus didengungkan agar mampu menangkal paham-paham liberalisme, individualisme, dan anti keragaman. Salah satu ciri negara yang demokratis adalah adanya kesiapan warga masyarakat dalam menyelesaikan setiap konflik yang ada. Setiap warga masyarakat sudah selayaknya saling memanusiakan, melindungi kaum minoritas. Dengan demikian, diharapkan dengan adanya pemilu tersebut mampu menjadi alat transformasi pada perubahan sosial yang lebih baik sehingga terbentuk pembaharuan demokrasi dan kedaulatan rakyat yang baik dan berintregritas di masa mendatang.
Méthodes alternatives in vitro pour l’étude des interactions hôte-pathogène du poumon
Authors: REMOT Aude , DESCAMPS Delphyne , ERNY Alexandra , CHOTTIN Claire , DRAJAC Carole , CARRERAS Florence , FERRET Cécile , ARCHER Fabienne 
Published: September 2023

Les maladies respiratoires, qu’elles touchent les animaux et/ou les hommes, ont un impact sanitaire et économique considérable sur notre société. Pouvoir mieux les contrôler, les traiter et les prédire, nécessite de pouvoir les étudier. Pour cela des modèles d’études pertinents, reproductibles, efficaces aisés d’utilisation, et alternatifs à l’expérimentation animale doivent être proposés. D’énormes progrès méthodologiques ont été réalisés ces dernières années avec l’émergence de modèles in vitro qui miment le poumon en reproduisant la diversité des types cellulaires, l’architecture du tissu et certaines de ses fonctionnalités (activité ciliaire, sécrétion). Cette revue présente les avancées dans la génération de ces modèles chez le bovin : les organoïdes, les cultures Air-liquide-interface (ALI) et les coupes fines de poumon (PCLS). Ils sont utilisés pour mieux décrire et comprendre les processus physiopathologiques induits par des infections (virus, bactérie, parasite) respiratoires et permettent de tester des approches prophylactiques ou curatives.
Les approches complémentaires à l’expérimentation animale en agronomie et clinique vétérinaire : Solutions et limites
Authors: PERRUCHOT Marie-Hélène , DESSAUGE Frédéric 
Published: September 2023

En France, l’utilisation des animaux à des fins scientifiques fait l’objet d’une réglementation stricte depuis plus de 25 ans. Son évolution s'effectue principalement dans un cadre européen. La directive 86/609 visait ainsi à l'harmonisation des pratiques entre les Etats membres. En France, comme en Europe, les textes réglementaires sur la protection animale et l’utilisation de l’animal en expérimentation sont de plus en plus exigeants. La directive 2010/63/UE du Parlement Européen et du Conseil du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques a fortement renforcé les exigences vis-à-vis de l’utilisation des animaux. Cette nouvelle directive s'attache plus particulièrement aux mesures concernant l’évolution du nombre d’animaux utilisés à des fins scientifiques et éducatives, cette utilisation « demeurant nécessaire pour protéger la santé humaine, la santé animale et l'environnement ». Le corpus réglementaire fait de la diminution du nombre d’animaux en expérimentation un défi majeur de la société scientifique. Des méthodes modernes telles que les méthodes in vitro, in silico et de modélisation permettent actuellement de diminuer le nombre d’animaux en expérimentation animale et d’être complémentaires à ces expérimentations. Ces méthodes sont en plein essor et il reste encore de nombreuses découvertes à faire afin de pouvoir répondre à plus de questions scientifiques par des méthodes alternatives.
Intérêts des cultures in vitro de cellules souches et d’organoïdes dans le cadre d’études toxicologiques
Authors: MORTAUD Stéphane , MÉRESSE Sarah , LARRIGALDIE Vanessa 
Published: September 2023

La toxicité de notre environnement et son impact sur la santé préoccupent de plus en plus la population. Certains polluants présents dans l’environnement peuvent affecter l’ensemble de l’environnement et des chaînes trophiques. Dans certains cas, ils peuvent affecter les animaux sauvages, les animaux domestiques, jusqu’à un transfert au sein de l’espèce humaine. Une intoxication correspond à une « introduction ou bio-accumulation d’une substance toxique dans l’organisme ». L’effet de ces substances toxiques est donc important à évaluer pour anticiper ses conséquences sur les organismes. Selon le modèle utilisé, ces évaluations peuvent contenir des biais importants. En effet le métabolisme est différent d’un organisme à l’autre, et donc la capacité à gérer un toxique de l’environnement, à le bio-accumuler ou à l’éliminer est spécifique de l’espèce. La toxicité pour l’animal les assimilant et la disponibilité de ces substances lors de la consommation humaine sont donc très variables. Cette problématique est retrouvée dans un autre contexte toxicologique, celui des drogues médicamenteuses. L’étude toxicologique devrait donc se faire de façon spécifique à l’espèce ciblée, y compris pour l’espèce humaine. En effet un écart important existe entre les résultats obtenus lors des phases pré-cliniques et ceux obtenus lors des essais cliniques. Par ailleurs l’utilisation des modèles animaux fait l’objet d’une réglementation au sein de l’union européenne qui s’attache particulièrement à la limitation de l’utilisation des animaux à des fins scientifiques quand cela est possible. Dans ces contextes se place toute l’importance de méthodes in vitro qui se sont développées au cours des dernières décennies grâce à l’avancée des connaissances fondamentales portant sur les cellules souches, ainsi que des avancées techniques qui y ont été associées. Ces méthodes ont permis la production de cultures en 3 dimensions mimant les structures réelles des organismes, d’où leur nom d’organoïdes. Ces outils deviennent des éléments clés des approches toxicologiques, qu’elles soient liées aux problèmes des expositions à des toxiques ou aux études précliniques humaines et vétérinaires.
Establishing the Callus-Based Isolation of Extracellular Vesicles from <em>Cissus Quadrangularis</em> and Elucidating Their Role in Osteogenic Differentiation
Authors: Gupta Ritu , Gupta Sneha , Gupta Purva , Nüssler Andreas K , Kumar Ashok 
Published: September 2023

Exosomes are membrane-bound, biologically active nanovesicles of size 30-200 nm produced by many cell types, such as both mammalian and plant cells. They are wrapped in a phospholipid bilayer and play a significant role in intercellular communications. The ease in their isolation and the ability of plant-derived exosome-like nanovesicles (PDEVs) to efficiently deliver bioactive constituents into mammalian cells have made them popular in contemporary research. PDEVs share many characteristics with mammalian EVs (MEVs), including shape, size, surface charge, and consist of bioactive molecules like lipids, proteins, nucleic acids, and tiny metabolites. However, the chemical composition profile of PDEVs and their biogenesis mechanism differ significantly from those of MEVs. They have been widely explored as potential therapeutic agents and are considered as good alternatives to act as a carrier for drug delivery. The present work elucidates the isolation of exosome-like-nanovesicles (henceforth exosomes) from the culture supernatants of an in vitro cultured callus tissue derived from a bone healing plant known for its osteogenic activity, i.e., Cissus quadrangularis. The physical and biological properties of exosomes were successfully studied using different characterization techniques. To assess their therapeutic potential, we studied the internalisation of calcein-AM labeled exosomes by human derived mesenchymal stromal cells (hMSCs). Additionally, we evaluated the potential of exosomes in the migration of cells in a cell scratch assay with hMSCs and their effect on amelioration of oxidative stress was investigated on preosteoblast MC3T3-E1 cells that were pre-treated with these exosomes. Furthermore, we investigated their proliferation and differentiation to osteoblasts like cells with the help of resazurin assay and alkaline phosphatase assay (ALP). The obtained results provide a primary justification for the use of Cissus quadrangularis-derived exosomes as a nanocarrier for drug molecules for various therapeutic bone applications.
Effect of Leaflets and Balanced Menu Videos on Knowledge, Attitudes and Behaviors among Undernourished Toddlers’ Mothers
Authors: Maftuchah Maftuchah , Setyaningsih Faridha , Nurhayati Susi 
Published: September 2023

<p><strong>Background:</strong> Toddlers are a vulnerable group in terms of nutrition and are at a high risk for disease. Toddlers’ nutritional health might be affected by a lack of nutrient intake. The nutritional status of children under the age of five is critical since it is an indicator of their health and nutritional status. Malnutrition continues to increase in Sukodono where there are currently 54 undernourished toddlers. This is due to the mother’s lack of knowledge. Counseling through leaflets and video screenings is one of the media for increasing mothers’ knowledge. This study aimed to analyzed the effect of leaflets and balanced menu videos on the knowledge, attitudes and behavior of malnourished mothers under five in the village of Sukodono Tahunan Jepara, Central Java.</p><p><strong>Methods</strong>: A quantitative research with quasi-experimental approach. The populations of the study were 54 undernourished toddlers at the aged 1 to 5 years. A total of 32 undernourished toddlers’ mothers in Sukodono were included in this study, and divided into 16 subjects from control group (using leaflet) and 16 subjects from intervention group (using video)<strong>. </strong></p><p><strong>Results:</strong> There was an effect of balanced menu leaflet media on the knowledge, attitudes, and behavior of malnourished toddler mothers in the village of Sukodono Tahunan Jepara. There is an effect of balanced menu video media on the knowledge, attitudes, and behavior of malnourished toddler mothers in Sukodono Tahunan village, Jepara. There is no more effective difference between giving leaflets and balanced menu videos on the knowledge, attitudes, and behavior of malnourished toddler mothers in Sukodono Tahunan Jepara village with p values &gt; 0.05 (0.434, 0.067 and 0.131).</p><p><strong>Conclusion:</strong> There is no more effective difference between the provision of leaflets and balanced menu videos on the knowledge, attitudes, and behavior of undernourished toddlers’ mothers in Sukodono Tahunan Jepara with a p value &gt; 0.05 (0.434, 0.067 and 0.131.</p><p> </p>
Sustainable Restoration of Degraded Landscapes Improves Soil Glomalin Content
Authors: Yelikbayev Bakhytzhan , Correa Eduardo , Duarte Neimar , Pagano Marcela 
Published: September 2023

Abstract
The rising use of plantations forwood and cropping systems for food, the agronomic pressures, and resource overexploitation, in addition to climate change constrains, need urgent efforts for restoration of the different vegetal covers. Thus, research in ecosystem restoration is rising worldwide as the perception that global change negatively affects ecosystem services as well as the above and belowground biodiversity. Among microorganisms, mycorrhizae and Rhizobia benefit and contribute to the natural regeneration of plant communities. Consequently, the study of mycorrhizas in natural ecosystems supplement with relevant information the restoration plans. The understanding that most plants are mycotrophic influences the rehabilitation efforts of varied vegetation types. We show here the ecosystem restoration with respect to the benefits of plant symbiosis. As an index of soil stabilization in the different sites glomalin content (Undisturbed= Restored > Disturbed), was the best predictor of restoration success.
Evaluation of a combined index based on hydrological model for drought monitoring in central Iran
Authors: Niazi Yaghoub , Talebi Ali , Hassan Marwan A. 
Published: September 2023

Abstract
In recent years, drought has become a global problem. Undoubtedly, drought monitoring is an important step for combating and reducing the resultant damage. In this study, the components of water and energy balance in the Central Iran region were simulated using the VIC land surface model. The output components of this model, especially soil moisture after evaluation, were used as inputs in the drought index based on Palmer's water balance. The integrated index of the VIC-PDSI in comparison with conventional Palmer indices and the SPI index at the 3, 6, 12, 24, and 48-month intervals was fitted with increments in moisture data and variations in the storage of water extracted from GRACE satellite data. Results showed that the combination of VIC-PDSI had the highest correlation coefficient of 0.87 with groundwater level change compared with other drought indices.