bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 2H‐1,4‐Oxazin‐3(4H)‐One Utilizing Umpolung Reaction to α‐Hydrazonoketone
Authors: Mizota Isao , Oshima Keiji , Hoshiai Nozomi , Yamamoto Ayaki , Mitani Masaki , Batool Rabbia , Liu Bo‐Tau , Shimizu Makoto 
Published: January 2025

Abstract2H‐1,4‐Oxazin‐3(4H)‐One Derivatives Are Known to Exhibit a Wide Range of Biological Activities Such as Antifungal, Anticancer, as Receptor Antagonists and Potassium Channel Modulators. In This Report, We Describe That α‐Hydrazonoketone Is an Appropriate Substrate for the Umpolung Reaction and a Promising Candidate for the Synthesis of 2H‐1,4‐Oxazine‐3(4H)‐Ones. Notably, Umpolung N‐Methylation for α‐Hydrazonoketone Proceeded Quantitatively in a Mild and Extremely Short Reaction Time, Which Has Been Difficult to Achieve in the Conventional Reactions. Moreover, We Also Developed Tandem Umpolung Reaction/Reduction/N‐Acyl‐O‐Alkylation to Afford 2H‐1,4‐Oxazin‐3(4H)‐Ones in High Yield in the Presence of Chloroacetyl Chloride.
Machine learning of endoscopy images to identify, classify, and segment sinonasal masses
Authors: Levi Lirit , Ye Kenan , Fieux Maxime , Renteria Axel , Lin Steven , Xing Lei , Ayoub Noel F. , Patel Zara M. , Nayak Jayakar V. , Hwang Peter H. , Chang Michael T. 
Published: January 2025

ABSTRACTBackgroundWe developed and assessed the performance of a machine learning model (MLM) to identify, classify, and segment sinonasal masses based on endoscopic appearance.MethodsA convolutional neural network‐based model was constructed from nasal endoscopy images from patients evaluated at an otolaryngology center between 2013 and 2024. Images were classified into four groups: normal endoscopy, nasal polyps, benign, and malignant tumors. Polyps and tumors were confirmed with histopathological diagnosis. Images were annotated by an otolaryngologist and independently verified by two other otolaryngologists. We used high‐ and low‐quality images to mirror real‐world conditions. The models used for classification (EfficientNet‐B2) and segmentation (nnUNet) were trained, validated, and tested at an 8:1:1 ratio. The performance accuracy was averaged across a 10‐fold cross‐validation assessment. Segmentation accuracy was assessed via Dice similarity coefficients.ResultsA total of 1242 images from 311 patients were used. The MLM was trained, validated, and tested on 663 normal, 276 polyps, 157 benign, and 146 malignant tumors images. Overall, the model performed at 84.1 ± 4.3% accuracy in the validation set and 80.4 ± 1.7% in the test set. The model correctly identified the presence of a sinonasal mass at 90.5 ± 1.2% accuracy rate. The MLM accuracy performance rates were 86.2 ± 1.0% for polyps and 84.1 ± 1.8% for tumors. Benign and malignant tumor subclassification achieved 87.8 ± 2.1% and 94.0 ± 2.4% accuracy, respectively. Segmentation accuracies for polyps were 72.3% and 72.8% for tumors.ConclusionsAn MLM for nasal endoscopy images can perform with moderate to high accuracy in identifying, classifying, and segmenting sinonasal masses. Performance in future iterations may improve with larger and more diverse training datasets.
In Situ Growth of Metal‐Organic Layer on Polyoxometalate‐etching Cu2O to Boost CO2 Reduction with High Stability
Authors: Wang Yu‐Jie , Cheng Xin , Ma Na‐Na , Cheng Wei‐Yi , Zhang Peng , Luo Fang , Shi Wen‐Xiong , Yao Shuang , Lu Tong‐Bu , Zhang Zhi‐Ming 
Published: January 2025

AbstractLow‐cost Cu2O with a suitable band gap holds great potential for solar utilization. However severe photocorrosion and weak CO2 capture capability have significantly hindered their application in artificial photosynthesis. Herein, polyoxometalate (POM)‐etching and in situ growth of metal–organic framework (MOF) can simultaneously incorporate electron‐sponge and HKUST protective layer into Cu2O. The resulting ternary composites Cu2O@POM@HKUST‐n (POM=PMo12O40 and PW12O40) with dual hetero‐interfaces can efficiently convert CO2 to HCOOH with 5226 μmol g−1 yield, over 5 and 55 times higher than that of Cu2O (1010 μmol g−1) and Cu2O@HKUST (95.02 μmol g−1). In situ XPS and DFT studies reveal that Cu mainly existed in the form of Cu2O and Cu‐MOF, while a unique Cux+ (1<x≤2) surface layer formed upon the Cu2O matrix surrounding POMs for CO2 absorption and activation. Systematic investigations demonstrate that the electron‐sponge can efficiently capture electrons from excited Cu2O to promote the generation of a Cux+ surface layer, while the closely surface‐coating metal‐organic layer can act as protective layer and CO2 adsorbent. This dual function concurrently contributes to promote photocatalysis and prevent Cu2O degradation. Remarkably, the composites exhibit much enhanced photochemical stability and can be used for over 60 h without noticeable activity loss.
Orderly Arranged Cubic Quantum Dots along Supramolecular Templates of Naphthalenediimide Aggregates
Authors: Manoj Lena Amrutha , Yamauchi Mitsuaki , Murakami Hideyuki , Kubo Naoki , Masuo Sadahiro , Matsuo Kyohei , Hayashi Hironobu , Aratani Naoki , Yamada Hiroko 
Published: January 2025

AbstractPrecise control of assembled structures of quantum dots (QDs) is crucial for realizing the desired photophysical properties, but this remains challenging. Especially, the one‐dimensional (1D) control is rare due to the nearly isotropic nature of QDs. Herein, we propose a novel strategy for controlling the 1D‐arrangement range of cubic perovskite QDs in solution based on the morphological modification of a supramolecular polymer (SP) template. The original template with a short and tangled fibrous structure is prepared in a low‐polarity solvent mixture via self‐assembly of a naphthalenediimide‐functionalized cholesterol derivative with an adhesion group for QDs. Mixing this template with QDs leads to the co‐aggregation into short‐range 1D‐arrays of QDs on the templates. Notably, subsequent heating and cooling of the co‐aggregate solution forms longer‐range 1D‐arrays of QDs with lateral growth, where arranged QDs are sandwiched between reconstructed SP templates. Furthermore, the longer‐range 1D‐array of QDs is achieved via an alternative route involving the pre‐organization of templates into longer and dispersed fibers by heating and cooling of the original template, succeeded by co‐assembly with QDs. Finally, we reveal continuous fluorescence resonance energy transfer between 1D‐arranged QDs by an in‐depth analysis of the photoluminescence decay curves.
Design, Synthesis and in vitro Evaluation of Primaquine and Diaminoquinazoline Hybrid Molecules Against the Malaria Parasite
Authors: Kore Mukul , Rao Anjani G. , Acharya Dimple , Kirwale Shrikant S. , Bhanot Amritansh , Govekar Abhishek , Mohanty Ajeet Kumar , Roy Aniruddha , Vembar Shruthi S. , Sundriyal Sandeep 
Published: January 2025

AbstractIn this study, we built on the known inhibitory potential of diaminoquinazolines (DAQs) against different stages of Plasmodium development and designed a convenient two‐step synthesis to combine DAQ with primaquine (PQ) pharmacophore. The PQ‐DAQ hybrids displayed potent in vitro activities in the low nanomolar range (IC50 135.20–398.80 nM) against all intra‐erythrocytic stages of the drug‐sensitive 3D7 strain, with significant potency enhancement compared to PQ alone (IC50 9370 nM). These hybrids were also potent at killing drug‐resistant strains (Dd2, Dd2 R539T, IPC4912, CamWT C580Y, and 7G8) in the nanomolar range, with 11 f being the most effective compound (IC50 172.20–396.60 nM). Notably, for the first time, we present evidence that the DAQ‐based compound 8 and its hybrids can inhibit β‐hematin formation in vitro with potency (IC50 0.90–27.80 μM), suggesting hemozoin formation to be one of the potential targets of this series. Lastly, two hybrids with potent antiplasmodial activity were also found to be safe up to 10 μM against human HepG2 cells, suggesting the possibility of achieving host vs parasite selectivity with this series.
Revisiting Variable Stars Near Globular Clusters South of −29° Declination
Authors: Layden Andrew C. , Evangelista Julia , Gupta Sakshi , Mittameda Mithilesh , Mulloy Eva , Muslim Sohan I. , Olushola‐Alao Tiyinoluwa , Rishi Akul 
Published: January 2025

ABSTRACTWe review an often‐cited but seldom‐accessed catalogue by Fourcade and Laborde (1966) of 785 variable stars near 47 southern Galactic globular clusters, and recover the locations of 85 stars that were not incorporated into subsequent variable star catalogues and hence have become “lost” to the literature. We match the positions of these stars with those of modern variable star databases (Gaia, ASAS‐SN, and VSX) and find 96% appear in at least one of these catalogues. We used proper motions and radial velocities from the Gaia Third Data Release to assess cluster membership, finding that most are field stars, but up to five may be members of NGC 5927 and one of NGC 6624.
The Effect of Fatalistic Tendency in Individuals on Attitudes Toward Epilepsy Patients
Authors: Adadioğlu Öznur , Seven Ahmet , Yıldız Metin 
Published: January 2025

ABSTRACTObjectiveThis study was conducted to determine the effect of fatalistic tendency on attitudes toward epilepsy patients.MethodsThe study was conducted between August 17 and October 1, 2022 in a family health center in Sakarya province in western Türkiye. The sample consisted of 479 adults. Data were collected in descriptive information forms, the fatalism tendency scale and the epilepsy attitude scale. The data were analyzed using SPSS 22.0, AMOS V 24.0, and G*Power 3.1 statistical package programs.ResultsResults showed that the model built according to the hypotheses was compatible, and the model fit indices χ2/Sd = 1.857, RMSEA = 0.04, CFI = 0.98, GFI = 0.99, AGFI = 0.97, and IFI = 0.98 were within the desired limits. Structural equation modeling to determine the effect of fatalistic tendency on attitudes toward epilepsy revealed that fatalistic tendency affected the attitudes toward epilepsy patients (β = 0.87, p < 0.05).ConclusionIn our study, as the fatalistic tendency of individuals increased, their negative attitudes toward epilepsy patients increased. Longitudinal studies on attitudes toward epilepsy patients are recommended.
Distinctive Delta and Theta Responses in Deductive and Probabilistic Reasoning
Authors: Sevim Emir Faruk , Yildirim Yasin , Ünsal Esra , Dalmizrak Esra , Güntekin Bahar 
Published: January 2025

ABSTRACTIntroductionThe neural substrates of reasoning, a cognitive ability we use constantly in daily life, are still unclear. Reasoning can be divided into two types according to how the inference process works and the certainty of the conclusions. In deductive reasoning, certain conclusions are drawn from premises by applying the rules of logic. On the other hand, in probabilistic reasoning, possible conclusions are drawn by interpreting the semantic content of arguments.MethodsWe examined event‐related oscillations associated with deductive and probabilistic reasoning. To better represent the natural use of reasoning, we adopted a design that required participants to choose what type of reasoning they would use. Twenty healthy participants judged the truth values of alternative conclusion propositions following two premises while the EEG was being recorded. We then analyzed event‐related delta and theta power and phase‐locking induced under two different conditions.ResultsWe found that the reaction time was shorter and the accuracy rate was higher in deductive reasoning than in probabilistic reasoning. High delta and theta power in the temporoparietal, parietal, and occipital regions of the brain were observed in deductive reasoning. As for the probabilistic reasoning, prolonged delta response in the right hemisphere and high frontal theta phase‐locking were noted.ConclusionOur results suggest that the electrophysiological signatures of the two types of reasoning have distinct characteristics. There are significant differences in the delta and theta responses that are associated with deductive and probabilistic reasoning. Although our findings suggest that deductive and probabilistic reasoning have different neural substrates, consistent with most of the studies in the literature, there is not yet enough evidence to make a comprehensive claim on the subject. There is a need to diversify the growing literature on deductive and probabilistic reasoning with different methods and experimental paradigms.
A Nationwide Exploration of Social Inequalities in Cancer Mortality Amidst the COVID‐19 Pandemic in Belgium
Authors: Khan Yasmine , Van den Borre Laura , Smedt Delphine De , Verhaeghe Nick , Devleesschauwer Brecht , Deboosere Patrick , Vanthomme Katrien , Gadeyne Sylvie 
Published: January 2025

ABSTRACTBackgroundThe COVID‐19 pandemic disrupted global health systems, impacting cancer care and potentially increasing cancer mortality, especially among socioeconomically disadvantaged individuals. We aimed to assess changes in cancer mortality from March 1 to December 31, 2020 relative to the same period in 2019, and to examine potential shifts in cancer mortality's social disparities during the same time frame.MethodsWe used nationwide individually linked cancer mortality data from the Belgian National Register, the Census 2011, and the tax register. Analyses were stratified by age group (45–59 years, 60–74 years, 75+ years) and sex across all cancer types, including breast, colorectal, lung, pancreatic, and prostate. Direct age‐standardized mortality rates were calculated in 2019 and 2020 to calculate absolute and relative changes in cancer mortality by social indicators. Relative inequalities in cancer mortality by social groups were calculated for both time frames using Poisson regression. Sensitivity analysis considered any mention of specified cancer groups on the Belgian death certificate.ResultsFor both overall and site‐specific cancers, our study found decreases in cancer mortality during the pandemic's early stages, particularly among individuals aged 75 and older. These changes did not significantly alter established socioeconomic patterns in cancer mortality.ConclusionsReductions in reported cancer deaths in 2020 may reflect COVID‐19 prioritization in cause‐of‐death coding and its role as a competing risk, rather than true declines. Persistent educational disparities emphasize the need for continued policy and healthcare collaboration, with future research focused on the pandemic's long‐term effects on cancer mortality and social inequalities.
Managing Jewish Identity in Arguments Over Jewish Support for Palestine
Authors: Goodman Simon 
Published: January 2025

ABSTRACTThe Israel/Palestine conflict has led to intragroup conflict amongst diaspora Jews that do and do not support Israel's actions. This paper addresses that conflict, which is shown to not just be one of differing opinions but of exactly what it means to be Jewish; it is therefore a social psychological study of contested and conflicting identities. Context to intra‐Jewish conflict and the concept of the ‘self‐hating Jew’ is discussed alongside the discursive approach to identity. The research question is: How is British Jewish identity managed and policed in a debate about Jewish support for Palestine? A critical discursive analysis is conducted on a Facebook discussion initiated by the British Jewish pro‐Palestinian organisation ‘Na'amod’, which contains over 300 interactions. The analysis shows that there is both support and criticism of Na'amod, with a major feature being the construction, by Jews, of what it means to be a Jew, including (1) supporting Israel and (2) attending a controversial march against antisemitism; together these actions constitute appropriate ‘Jewish ethics’ so that not doing these places a Jew as deficient because of self‐hate and/or stupidity. The analysis therefore shows how Jewish identity is constructed in such a way as to police Jewish people's behaviour and ensure support for Israel.
Anti‐Inflammatory Withanolides From Physalis angulata Var. villosa Bonati
Authors: Zhang Yu , Xu Hong‐Zhi , Wang Peng , Yu Yan , Liu Juan , Hao Xiao‐Jiang , Yuan Chun‐Mao , Jin Jun , Yi Ping 
Published: January 2025

ABSTRACTTwo new withanolide derivatives (1 and 2) and 12 known withanolide analogs (3–14) were identified from the aerial part of Physalis angulata var. villosa Bonati. Their structures were determined by various spectral data, quantum chemical calculations, and sugar derivatization methods. Three compounds (2, 3, and 14) demonstrated good nitric oxide inhibitory effects against lipopolysaccharide‐stimulated RAW264.7 cells, with IC50 values of 4.93 ± 0.22–8.58 ± 0.83 µM. The present study suggests that withanolide derivatives have potential anti‐inflammatory activity and could be used to treat inflammation‐related diseases. Moreover, the chemotaxonomic implications of the isolates are further investigated.
Efficacy and Safety of Sirolimus‐Coated Balloon Angioplasty in De Novo Lesions in Large Coronary Vessels: A Propensity Score‐Matched Study
Authors: Gobbi Cecilia , Giangiacomi Francesco , Pasero Guido , Faggiano Andrea , Barbieri Lucia , Tumminello Gabriele , Colombo Federico , Ruscica Massimiliano , Ardizzone Valentina , Genta Edoardo , Mircoli Luca , Galli Stefano , Carugo Stefano 
Published: January 2025

ABSTRACTBackgroundEvidence regarding drug‐coated balloon (DCB)‐only angioplasty in de novo lesions of large vessels is still limited and mainly focused on paclitaxel‐coated balloon. We aimed to analyze the safety and efficacy of sirolimus‐coated balloon (SCB)‐only angioplasty in de novo lesions in large vessels compared to drug‐eluting stent (DES).MethodsIn this retrospective, dual‐center, case‐control study, we enrolled all consecutive patients treated between January 2022 and January 2024 with SCB‐only angioplasty in de novo lesion in large vessel (> 2.75 mm) compared to a propensity‐score matched contemporary population treated with DES. The primary endpoint was the rate of target lesion revascularization (TLR), while secondary endpoints were cardiac death (CD), target vessel revascularization (TVR), myocardial infarction (MI), and target lesion failure (TLF), defined as a composite of them.ResultsThe mean age was 70.1 ± 9.8 years in the SCB group (n = 92) and 67.9 ± 9.6 years in the DES group (n = 92) (p = 0.76). The median follow‐up was 19.5 ± 12 months in the SCB group and 20.1 ± 13.1 months in the DES group (p = 0.47). TLR occurred in 6.7% of patients in the SCB group and 5.6% in the DES group (p = 0.75). The incidence of MI, TVR, and TLF were similar between the two groups (4.3% vs 3.3%, p = 0.7, 2.2% vs 3.4%, p = 0.65% and 9.8% vs 8.7%, p = 0.79). CD occurred in 4.3% in the SCB group, compared to 3.3% in the DES group (p = 0.70).ConclusionOur study suggests that SCB angioplasty is both safe and effective in the treatment of de novo lesions of large vessels compared with DES.
Contemporary Use of Post‐Dilatation for Stent Optimization During Percutaneous Coronary Intervention; Results From the Netherlands Heart Registration
Authors: van Beek K. A. J. , Timmermans M. J. C. , Derks L. , Cheng J. M. , Kraaijeveld A. O. , Arkenbout E. K. , Schotborgh C. E. , Brouwer J. , Claessen B. E. , Lipsic E. , Polad J. , van Nunen L. X. , Sjauw K. , van Veghel D. , Tonino P. A. , Teeuwen K. ,   ‘on behalf of the PCI registration committee of The Netherlands Heart Registration’
Published: January 2025

ABSTRACTBackgroundsPost‐dilatation after stenting with a non‐compliant (NC) balloon can be used to improve overall percutaneous coronary intervention (PCI) result. Due to lack of evidence on the effect of post‐dilatation on adverse clinical endpoints there is no consensus whether post‐dilatation should be used routinely. The aim of the current study was to determine the contemporary practice of post‐dilatation.MethodsThis study included patients from the Netherlands Heart Registration who underwent PCI between the 4th quarter of 2020 and the 3rd quarter of 2021. The primary endpoint was the rate of post‐dilatation with a NC balloon. Secondary endpoints included differences in baseline and procedural characteristics of patients that received post‐dilatation and patients that did not receive post‐dilatation.ResultsOut of 12,960 patients from 11 hospitals, 49.9% underwent post‐dilatation. There was a variety in post‐dilatation between hospitals ranging from 29.3% to 82.7% and among operators ranging from 15.9% to 90.5%. Post‐dilatation was used less frequent in patients presenting with ST‐elevation myocardial infarction or out of hospital cardiac arrest. Multivessel and left main PCI, long stent length and use of intracoronary imaging and calcium modification were associated with increased use of post‐dilatation. When imaging was used, the percentage of post‐dilatation was 79.4%.ConclusionsIn the Netherlands, stent optimization with post‐dilatation using NC balloon is performed in only half of the patients undergoing PCI, with variations in frequency across centres and operators. Post‐dilatation is more often used in cases of complex PCI and when intracoronary imaging or calcium modification techniques are used.
Novel Copy Number Deletion Involving NUS1 Associated With Epilepsy, Tremor, and Intellectual Disability
Authors: Hsu Jing Y. , Ibrahim Daniah H. , Ali Riza , Marchi Elaine , Gavin Maureen , Amble Karen , Lyon Gholson J. 
Published: January 2025

ABSTRACTCopy number variations (CNVs) contribute to various disorders including intellectual disability, developmental disorders, and cancer. This study identifies a de novo 2.62 Mb deletion at 6q22.1_q22.31, implicating the NUS1 gene in epilepsy, spinal abnormalities, and intellectual disability, thereby expanding its known phenotypic associations.
EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review
Authors: Li Qiongqian , Cai Tongze , Zheng Xiaoming , Zhang Shunrong , Li Chanjuan , Tang Huang , Yu Zhiyong , Zhou Jianlong 
Published: January 2025

ABSTRACTWe report a case showing that lorlatinib is effective in treating EML4‐ALK‐positive low‐grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ovarian cancer patients with EML4‐ALK fusion and promoting new ideas for the study of EML4‐ALK targets in ovarian cancer.
Functional Endoscopic Sinus Surgery in Management of Pott's Puffy Tumor in a Pregnant Woman: A Clinical Case Report and Literature Review
Authors: Dehghan Manshadi Seyed Ali , Tabari Azin , Saffar Hana , Salahshour Faeze , Shafiee Nahid , Izadpanah Azam Sadat , Piri Seyed Mohammad 
Published: January 2025

ABSTRACTPPT is a life‐threatening intracranial complication, which is essential to be considered in both children and adults presenting with sinusitis symptoms.
Eyelid Spindle Cell Lipoma: Case Report and Review of Three Patients in Literature
Authors: Matsuo Toshihiko , Yamada Kiyoshi , Monobe Yasumasa , Tanaka Takehiro 
Published: January 2025

ABSTRACTA 39‐year‐old woman presented a saucer‐shaped mass in the left upper eyelid and underwent the extirpation at local anesthesia. Pathologically, collagen fibers, capillaries, small vessels, and CD34‐positive spindle cells were dispersed among mature adipose tissues, indicative of spindle cell lipoma. Long‐lasting cyst‐like eyelid masses would be usually dermoid cysts, and spindle cell lipoma would be listed as a rare pathological diagnosis in differential diagnoses of cyst‐like lesions in the upper and lower eyelid.