bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Medialog Sebagai Media Kampanye Moderasi Beragama Bagi Kaum Milenial
Authors: Tuhuteru Ajuan , Murdiati Erni , Sukmawati Lilis 
Published: June 2023

Kehadiran media baru merubah seluruh hidup manusia, termasuk dalam hal mengakses informasi. Konsep moderasi beragama telah menjadi prioritas pemerintah dalam membangun kesadaran masyarakat tentang keberagaman, namun hal itu masih belum optimal dalam menyasar semua kalangan. Oleh karenanya perlu adanya elaborasi dalam sebuah riset. Artikel ini bertujuan untuk mengetahui pengembangan media digital berbasis blog sebagai media kampanye moderasi beragama yang disingkat “MeDiaLog”, kelayakan dan juga kepraktisan dari media kampanye tersebut. Metode penelitian yang digunakan adalah jenis penelitian dan pengembangan (Research and Development) dengan model pengembangan ADDIE. Uji kelayakan atau validasi MeDiaLog dilakukan oleh ahli isi, ahli media, dan pengguna. Uji coba terhadap MeDiaLog dilakukan sebanyak dua tahapan: uji coba kelompok kecil melibatkan 15 orang, sementara uji coba kelompok besar melibatkan 100 orang. Hasil penelitian pengembangan media digital berbasis blog sebagai media kampanye moderasi beragama, setelah melewati tahapan analisis, perencanaan/desain, dan pengembangan yang telah disetujui oleh ahli materi mapun ahli media dapat dilihat pada link blog: https://maluku-rumahmoderasi-beragama.blogspot.com/. Selanjutnya untuk kelayakan, setelah dinilai oleh ahli materi dan ahli madia, diperoleh nilai 4,85 dengan kategori sangat baik oleh ahli materi/isi, ahli media dengan nilai rata-rata 3,8 berada pada kategori baik. Sementara uji coba terbatas kelompok kecil mendapati nilai rata-rata 4,205 dengan kategori Baik. Berikutnya untuk kepraktisan dari medialog itu sendiri setelah dilakukan uji coba terbatas kelompok besar mendapati nilai rata-rata untuk aspek materi dan aspek tampilan adalah 4,325 yang berada pada kategori sangat baik. Dengan demikian, dapat disimpulkan bahwa MeDiaLog sebagai media kampanye moderasi beragama sudah teruji kelayakannya untuk digunakan sebagai media kampanye.
ANALISIS PENGARUH PROFIL SUDUH TERHADAP DAYA TURBIN VORTEX
Authors: Marfizal Marfizal , Sufiyanto Sufiyanto , Wardianto Dedi 
Published: June 2023

Abstrak
Turbin vortex adalah turbin yang beroperasi dengan memanfaatkan aliran vortex sebagai penggerak sudu-sudu turbin yang kemudian poros turbin dihubungkan ke generator untuk mengkonversi energi mekanis poros kedalam bentuk energi listrik. Pada penelitian ini akan dilakukan pengujian terhadap turbin vortex dengan head 1 m, debit aliran 0,12 m3/s. dalam proses pengujian akan di gunakan 3 jenis sudu, yaitu sudu lurus, sudu lengkung dan sudu lengkung bersirip. Setelah dilakukan pengujian dapat disimpulkan bahwa daya tertinggi terdapat pada sudu lengkung sebesar 959,08 watt dan berikutnya sudu lengkung bersirip 714.38 watt, sedang kan daya terendah terdapat pada jenis sudu lurus 582.48 Watt. Untuk putaran yang dihasilkan dapat terlihat pada grafik dibawah, Putaran tertinggi terdapat pada sudu lengkung bersirip sebesar 540,00 rpm dan berikutnya sudu lengkung 517.67 rpm, sedang kan putran terendah terdapat pada jenis sudu lurus 510.67 rpm. Untuk effisiensi masing masin sudu terhat bahwa sudu lengkung masih tertinggi dan diikuti sudu jenis lengkung bersirip, terendah sudu lurus dengan effisiensi masin masin 98 %, 73 % dan 59%.
Open Genes — A New Comprehensive Database of Human Genes Associated With Aging and Longevity
Authors: Rafikova Ekaterina , Nemirovich-Danchenko Nikolay , Ogmen Anna , Parfenenkova Anna , Velikanova Anastasiia , Tikhonov Stanislav , Peshkin Leonid , Rafikov Konstantin , Spiridonova Olga , Belova Yulia , Glinin Timofey , Egorova Anastasia , Batin Mikhail 
Published: June 2023

Abstract
The Open Genes database was created to enhance and simplify the search for potential
aging therapy targets. We collected data on 2402 genes associated with aging and
developed convenient tools for searching and comparing gene features. A
comprehensive description of genes has been provided, including lifespan-extending
interventions, age-related changes, longevity associations, gene evolution, associations
with diseases and hallmarks of aging, and functions of gene products. For each
experiment, we presented the necessary structured data for evaluating the experiment’s
quality and interpreting the study’s findings. Our goal was to stay objective and precise
while connecting a particular gene to human aging. We distinguished six types of
studies and 12 criteria for adding genes to our database. Genes were classified
according to the confidence level of the link between the gene and aging. All the data
collected in a database are provided both by an API and a user interface. The database
is publicly available on a website at https://open-genes.org/.
Does the Use of Antenatal Corticosteroids Reduce Respiratory Morbidity in Babies Born in Late Preterm Period?
Authors: Shittu Khadijah A. , Rabiu Kabiru Afolabi , Ahmed Bolaji , Akinola Oluwarotimi I. , Akinlusi Fatimat 
Published: June 2023

Abstract

Objective
The aim of this study is to determine the effectiveness of antenatal corticosteroid in reducing respiratory morbidity in babies born in the late preterm period.
Materials and methods
Two hundred and eighty-six pregnant women at risk of having a late preterm delivery were studied. One hundred and forty-three (143) served as the cases and were given 2 doses of 12mg intramuscular dexamethasone 12 hours apart, while 143 served as the controls and were given a similar quantity of placebo. The women were followed up prospectively and data were collected on the pregnant women and their newborns on a standardized form. The neonates were assessed for acute respiratory distress syndrome and transient tachypnea of the newborn based on clinical signs, symptoms, and chest x-ray results (when indicated). The primary outcome was the occurrence of neonatal respiratory morbidity.
Results
The primary outcome occurred in 5 out of 130 infants (3.8%) in the dexamethasone group and 31 out of 122 (25.4%) in the placebo group (P value = 0.000003). Birth asphyxia, neonatal intensive care admission and need for active resuscitation at birth also occurred significantly less frequently in the dexamethasone group (P value 0.004, 0.009, 0.014 respectively). There were no significant group differences in the incidence of neonatal sepsis, neonatal jaundice, hypoglycemia and feeding difficulties.
Conclusion
Administration of dexamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications neonatal intensive care unit and need for active resuscitation at birth.
Trial Registration: PACTR (www.pactr.org) Registration Number: PACTR202304579281358. The study was retrospectively registered on April 19, 2023.
Effect on Functional Outcome of Robotic Assisted Rehabilitation Versus Conventional Rehabilitation in Patients with Complete Spinal Cord Injury: A Prospective Comparative Study
Authors: Khande Chandra , VERMA VISHAL , Regmi Anil , Ifthekar Syed , Sudhakar P , SETHY SIDDHARTH , Kandwal Pankaj , Sarkar Bhaskar 
Published: June 2023

Abstract
Study Design: Prospective Comparative Study
Objective:This study aims to compare the functional outcomes of Robotic-assisted rehabilitation by Lokomat system Vs. Conventional rehabilitation in patients with Dorsolumbar complete spinal cord injury.
Methods: 15 patients with Dorsolumbar spinal cord injury with ASIA A neurology were allocated to robotic rehabilitation and 15 patients to conventional rehabilitation after an operative procedure. Pre-rehabilitation parameters were noted in terms of ASIA Neurology, Motor, and sensory function scores, WISCI II score (Walking Index in Spinal Cord Injury score), LEMS (Lower Extremity Motor Score), SCIM III score (Spinal Cord Independence Measure III score), AO Spine PROST (AO Patient Reported Outcome Spine Trauma), McGill QOL score (Mc Gill Quality Of Life score), VAS score (Visual Analogue Scale) for pain and Modified Ashworth scale for spasticity in lower limbs.
Results: On comparing of robotic group to conventional group there was a statistically significant improvement in group in terms of Motor score, WISCI II score, SCIM III score, AO PROST score, Mc GILL QOL score, Max velocity, and Step length. While LEMS score, ASIA neurology, VAS score, Sensory score, and Modified Ashworth scale for spasticity were not statically significant while comparing between two groups.
Conclusion: Robot-assisted rehabilitation is superior than conventional rehabilitation in Spinal Cord Injury patients. Variations in results found in the literature for robotic assisted training are probably a result of factors such as differences in type and severity of lesion, time of onset to entry in rehab the devices used, application of the interventions and control interventions.
Level of Evidence: III
Pulmonary function and sarcopenia as predictors of dysphagia in cervical spinal cord injury
Authors: Lee Su Ji , Shin Ji Cheol 
Published: June 2023

Abstract
Study design:
Retrospective cohort study.
Objective:
To determine the risk factors associated with dysphagia in individuals with cervical spinal cord injury (CSCI) and analyze the differences between individuals with improved penetration-aspiration (PA) and persistent PA on follow-up.
Setting:
Tertiary inpatient rehabilitation facilities.
Methods:
Medical records of individuals with CSCI admitted between December 2009 and February 2023 who underwent a videofluoroscopic swallowing study (VFSS) were retrospectively reviewed. Multivariate logistic regression analysis was performed to assess risk factors for dysphagia. Differences between individuals with improved PA and persistent PA were analyzed using an independent t-test.
Results:
In total, 149 participants were enrolled. Age (odds ratio (OR) 1.077, 95% confidence interval (CI), 1.043 to 1.118), percentage of forced vital capacity to predicted normal (FVC (% predicted)) (OR 0.897, 95% CI, 0.850 to 0.941), and skeletal muscle mass ratio (SMMR) (OR 0.888, 95% CI, 0.791 to 0.991) were significant factors associated with the risk of PA. According to the receiver operating characteristic curve analysis, the cut-off values for age, FVC (% predicted), and SMMR were 55.50, 46.11, and 41.01, respectively. A secondary analysis of the follow-up VFSS was performed in 38 participants. The follow-up FVC(%predicted) and degree of weight loss differed significantly between the improved PA and persistent PA groups.
Conclusions:
Older age, low FVC (% predicted), and low SMMR can be predictors of dysphagia in patients with CSCI. On follow-up VFSS, individuals with improved PA demonstrated greater improvement in FVC (% predicted).
The long-term efficacy of strength or aerobic exercise on quality of life and knee function in patients with knee osteoarthritis. A multi-arm randomized controlled trial
Authors: Øiestad Britt Elin , Årøen Asbjørn , Røtterud Jan Harald , Østerås Nina , Jarstad Even , Grotle Margreth , Risberg May Arna 
Published: June 2023

Abstract
Objective
To evaluate the efficacy of strength exercise or aerobic exercise compared to usual care on knee-related quality of life (QoL) and knee function after 4 months and 1 year in individuals with knee osteoarthritis.
Methods
A three-arm randomized controlled trial (RCT) compared 12-weeks of strength exercise or aerobic exercise (stationary cycling) to usual care supervised by physiotherapists in primary care. We recruited 168 participants aged 35–70 years with symptomatic knee osteoarthritis. Primary outcome was The Knee Injury and Osteoarthritis Outcome Score (KOOS) QoL after 1 year. Secondary outcomes were self-reported function, pain, and self-efficacy, muscle strength and voluntary maximal oxygen consumption (VO2peak) at 4 months and 1 year.
Results
There were no differences between strength exercise and usual care on KOOS QoL (6.5, 95% CI -0.9 to 14), or for aerobic exercise and usual care (5.0, 95% CI -2.7 to 12.8), at 1 year. The two exercise groups showed better quadriceps muscle strength, and VO2peak at 4-months, compared to usual care.
Conclusion
This trial found no statistically significant effects of two exercise programs compared to usual care on KOOS QoL after 1 year in individuals with symptomatic and radiographic knee osteoarthritis, but an underpowered sample size may explain lack of efficacy between the intervention groups and the usual care group.
Analysis of Thermal Performance of Bimorph Piezoelectric Energy Harvesters
Authors: Shirbani Meisam Moory , alavi sayed ehsan , Hassani Ali Mojadam 
Published: June 2023

Abstract
Temperature gradients haven't been discussed much in the past, but these harvesting systems might be exposed to them. Temperature changes will affect the shape of the piezoelectric layers, so in order to bring the study conditions of these harvesters closer to the real conditions, the effect of temperature gradient should be investigated. The proposed method employs a clamped beam with a three-layer configuration. Two layers of PZT-5H piezoelectric material and a middle layer of aluminum material are used. The base vibrations applied to the harvester beam and the temperature difference between the layers of the harvester will cause mechanical stress in the piezoelectric layers. With the analytical modeling of the governing structural equations and the use of Ohm's and Gauss's laws, as well as considering the temperature difference of the harvester beam surfaces and assuming constant heat transfer without a heat source, coupled mechanical-electrical-thermal differential equations based on Euler-Bernoulli's assumptions are extracted. The results for two symmetric and asymmetric modes have been presented in this work, and temperature changes have been modeled. The results indicate that the best case for harvesting energy is one where the thickness of the piezoelectric layers is twice that of the homogeneous layer, and the best connection is also a series connection. The highest harvested power density corresponds to 70°C.
Risk Factors for Developing Neovascular Glaucoma in Central Retinal Vein Occlusion: a 2-year Longitudinal Real-World Study
Authors: Chou Yu-Bai , Chang Hsin-Ho , Chiu Hsun-I , Chou Yiing-Jenq , Pu Christy 
Published: June 2023

Abstract
Background/Objective:
To explore potential risk factors for the development of neovascular glaucoma (NVG) in central retinal vein occlusion (CRVO) over a two-year intensive follow-up period.
Subjects/Methods:
This study reviewed 1545 patients with CRVO between 2005 and 2019 at Taipei Veterans General Hospital. Inclusion was restricted to (1) patients with acute CRVO within 3 months; (2) patients with ocular neovascularization at initial presentation (3) patients had not received any treatment at the time of CRVO; (4) at least bimonthly follow-up schedule over the course of 2 years. The included patients were screened for potential risk factors for developing NVG and assessed with Kaplan-Meier survival analysis and Cox regression model.
Results:
Among the included 123 patients, the cumulative probability of developing NVG was 26.8% (33/123 cases) in overall follow-up period. The mean interval between the onset of CRVO and NVG was 507 days. Neither macular edema nor central macular thickness at baseline was correlated with the development of NVG (p = .104 and .25, respectively). Patients with DM, older age, and poor vision independently played significant risk factors for developing NVG after controlling other covariates. (p = .034, .001, and .013, respectively).
Conclusions:
Patients presenting with CRVO who have comorbidities such as DM, older age, and worse VA warrant closer attention and intensive follow-up for the development of NVG. Additionally, the statistical analysis indicated that the presence of macular edema, increased central macular thickness, CV events, history of glaucoma, and early PRP within 3 months had no significant impact on the likelihood of developing NVG.
Curated incidence of lysosomal storage diseases from the Taiwan Biobank
Authors: Tsai Meng-Ju Melody , Hung Miao-Zi , Lin Yi-Lin , Lee Ni-Chung , Chien Yin-Hsiu , Hwu Wuh-Liang 
Published: June 2023

Abstract
Lysosomal storage diseases (LSDs) are a group of metabolic disorders resulting from a deficiency in one of the lysosomal hydrolases. Most LSDs are inherited in an autosomal or X-linked recessive manner. As LSDs are rare, their true incidence in Taiwan remains unknown. In this study, we used high-coverage WGS data from 1,495 Taiwanese individuals obtained from the Taiwan Biobank. We found 3,826 variants in 71 genes responsible for autosomal recessive LSDs. We first excluded benign variants by allele frequency and other criteria. As a result, 270 variants were considered disease-causing. We curated these variants using published guidelines from the American College of Medical Genetics and Genomics (ACMG). Our results revealed a combined incidence rate of 13 per 100,000 (conservative estimation by pathologic and likely pathogenic variants; 95% CI 6.92-22.23) to94 per 100,000 (extended estimation by the inclusion of variants of unknown significance; 95% CI 75.96-115.03) among 71 autosomal recessive disease-associated genes. The conservative estimations were similar to those in published clinical data. No disease-causing mutations were found for 18 other diseases; thus, these diseases are likely extremely rare in Taiwan. The study results are important for designing screening and treatment methods for LSDs in Taiwan and demonstrate the importance of mutation curation to avoid overestimating disease incidences from genomic data.
Effects of an animated educational video on knowledge of cell-free DNA screening among pregnant women: A randomized control trial
Authors: Nintao Nutta , Manonai Jittima , Wattanayingcharoenchai Rujira , Bumrungphuet Sommart , Hansahiranwadee Wirada , Dulyaphat Wirada , Somchit Werapath , Wattanasirichaigoon Duangrurdee , Prakobpanich Maneerat , Tangshewinsirikul Chayada 
Published: June 2023

Abstract
Background
In middle-income developing countries, pregnant women had insufficient knowledge about cell-free DNA screening. Reports from developed countries have found that various tools in prenatal genetic counseling can improve the knowledge of pregnant women who undergo cell-free DNA screening. Data are limited from developing countries where women have different baseline socio-educational backgrounds. The objective of this study was to compare the effects of an animated educational video combined with traditional counseling versus traditional counseling alone in changing pregnant women’s knowledge of cell-free DNA screening.
Methods
This study was a randomized control trial at an antenatal clinic. Eligible subjects who were Thai pregnant women, were randomized to either view or not view the video explaining cell-free DNA screening. Both groups received traditional counseling. The women were asked to complete a questionnaire assessing knowledge of the screening before and after intervention. Primary outcome was the change in knowledge scores. Secondary outcomes were attitudes toward positive results, levels of satisfaction with counseling, and screening acceptance rates.
Results
Data from 83 women in the video group and 82 in the non-video group were analyzed. The knowledge score change after counseling was significantly higher in the video group than the non-video group (+ 7.1 ± 3.3 vs + 4.2 ± 2.5; p = 0.026). There were no significant differences in attitudes toward positive results (p = 0.187), levels of satisfaction (p = 0.28), or screening acceptance rates (p = 0.15) between the groups.
Conclusions
Adding the video to traditional counseling was better than traditional counseling alone in improving pregnant women’s knowledge about cell-free DNA screening.
Managing non-acute subdural hematoma using liquid materials: a Chinese randomized trial of MMA treatment (MAGIC-MT) – Protocol
Authors: Zuo Qiao , Ni Wei , Yang Pengfei , Gu Yuxiang , Yu Ying , Yang Heng , Majoie Charles BLM , Goyal Mayank , Liu Jianmin , Mao Ying 
Published: June 2023

Abstract
• Background:
The conventional treatments for non-acute subdural hematoma (SDH) are facing the challenge of high hematoma recurrence and progression. A novel treatment of middle meningeal artery (MMA) embolization showed the potential role in decreasing the recurrence and progression rate of SDH compared to conventional treatments in multiple cohort studies. A randomized controlled trial is warranted to determine the effectiveness and safety of MMA embolization for non-acute hematoma, and whether MMA embolization is superior to conventional treatments to lower the symptomatic recurrence and progression rate of non-acute SDH.
• Methods:
This is an investigator-initiated, multi-center, prospective, open-label parallel group trial with blinded outcome assessment (PROBE design) assessing superiority of MMA embolization compared to conventional treatments. A total of 722 patients are planned to be randomized 1:1 to receive MMA embolization (intervention) or conventional treatments (control). The primary outcome is the symptomatic SDH recurrence/progression rate within 90±14 days post-randomization.
• Discussion:
This trial will clarify whether MMA embolization could reduce the recurrence or progression rate of symptomatic non-acute SDH compared to conventional treatment.
Trial registration:
ClinicalTrials.gov Identifier: NCT04700345, Registered on 7 Jan 2021
Retinal layer thickness and optic disk parameters in different types of amblyopia
Authors: Zhu Xixi , Zheng Qianlan , Chen Jie , Chen Wuhe 
Published: June 2023

Abstract
Objectives
To quantify the retinal layer thickness and optic disk parameters in different types of amblyopia.
Methods
In this prospective cross-sectional study, 78 amblyopic children (5–12 years) and 43 age-matched control subjects participated at a pediatric ophthalmology clinic. Retinal layer thickness and optic disk parameters were measured by spectral domain optical coherence tomography (SD-OCT) and compared between amblyopic groups and the control group.
Results
Of the 78 amblyopic children, 48 children had anisometropic amblyopia, 16 had strabismic amblyopia, and 14 had bilateral amblyopia. Exploring intraretinal layers, there were significant differences in thickness in several retinal layers between anisometropic and strabismic amblyopic eyes and fellow eyes or control eyes in the foveal, parafoveal and perifoveal regions: retinal nerve fiber layer (RNFL) (P ≤ 0.037), ganglion cell layer and inner plexiform layer (GCL + IPL, p = 0.022), and outer plexiform layer (OPL, p ≤ 0.007). The nasal circum-papillary RNFL (cpRNFL) in anisometropic and strabismic amblyopic eyes was significantly thinner than that in control eyes (p = 0.032 and 0.033, respectively). There were also significant differences in the cup/disk area ratio (p = 0.022 and 0.023), cup/disk vertical ratio (p = 0.036 and 0.007), and cup volume (p = 0.020 and 0.043) between anisometropic and strabismic amblyopic eyes and control eyes. However, no significant difference was found between bilateral amblyopic eyes and control eyes in any of the retinal parameters.
Conclusions
Unilateral amblyopia demonstrated abnormalities in some retinal parameters compared with fellow eyes or control eyes, while bilateral amblyopia did not. The pathogenesis may be different between unilateral amblyopia and bilateral amblyopia.