bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verrucous Carcinoma, A Very Well Differentiated Form of OSCC? - An Immunochemical Exploratory Study
Authors: Yellapurkar Shweta , Boaz Karen , N Srikant , Manaktala Nidhi , KP Nandita , Lewis Amitha J. 
Published: April 2023

Introduction:
Verrucous carcinoma shows an analogous biological behaviour to well-differentiated Oral Squamous Cell Carcinoma (OSCC). So, it is a difficult task to differentiate the above two entities based on clinical and pathological behaviour. Immunohistochemical studies can help in investigating the differences between the biological behaviours of these carcinomas. Laminin may be used as a status indicator of intact or degraded basement membrane during tumorigenesis. Thus, the present study aimed to assess the immunohistochemical expression of laminin in different grades histological grades of OSCC and VC.

Methods:
Laminin expression was evaluated in 31 biopsy-proven cases of Oral Squamous Cell Carcinoma (OSCC) and 10 cases of Verrucous Carcinoma (VC).

Results:
We observed that most cases of VC (90%) were negative or mildly stained for cytoplasmic laminin while the majority of cases of OSCC (74.2%) stained moderately for the same. Further, VC cases showed a total absence of linear laminin staining around the tumour-host interface in contrast to 13% of OSCC cases that were correspondingly stained (p<0.001).

Conclusion:
The present study, therefore concludes that the interface expression in Verrucous Carcinoma distinctly differed from that in well-differentiated Oral Squamous Cell Carcinoma. Cytoplasmic laminin expression increased and interface staining decreased with unfavourable clinicopathological outcomes thereby rendering laminin an expedient marker in evaluating the histological differentiation and aggressiveness of oral carcinoma
Detection of Prostate Cancer using Ensemble based Bi-directional Long
Short Term Memory Network
Authors: Kaulgud Sanjeev , Hulipalled Vishwanath , Patil Siddanagouda Somanagouda , Metipatil Prabhuraj 
Published: April 2023

Aim and Background:
In recent periods, micro-array data analysis using soft computing
and machine learning techniques gained more interest among researchers to detect prostate cancer.
Due to the small sample size of micro-array data with a larger number of attributes, traditional machine
learning techniques face difficulty detecting prostate cancer.

Methodology:
The selection of relevant genes exploits useful information about micro-array data,
which enhances the accuracy of detection. In this research, the samples are acquired from the gene
expression omnibus database, particularly related to the prostate cancer GEO IDs such as GSE
21034, GSE 15484 and GSE 3325/GSE 3998. In addition, ensemble feature optimization technique
and Bidirectional Long Short Term Memory (Bi-LSTM) network are employed for detecting prostate
cancer from the microarray data of gene expression.

Results:
The ensemble feature optimization technique includes 4 metaheuristic optimizers that select
the top 2000 genes from each GEO IDs, which are relevant to prostate cancer. Next, the selected
genes are given to the Bi-LSTM network for classifying the normal and prostate cancer subjects.

Conclusion:
The simulation analysis revealed that the ensemble based Bi-LSTM network obtained
99.13%, 98.97%, and 94.12% of accuracy on the GEO IDs like GSE 3325/GSE 3998, GSE 21034,
and GSE 15484.
Voriconazole Loaded Lipidic Nanoparticles for Ophthalmic Delivery:
Development Using QbD Combined with Risk-based Approach
Authors: Patel Akanksha , Dharamsi Abhay 
Published: April 2023

Background:
Voriconazole (VRZ) is widely used for fungal keratitis topically. It is spar-ingly water soluble and has limited permeability which can lead to poor bioavailability. Nanostruc-tured Lipid Carriers (NLCs) are selected as a carrier for voriconazole as they increase solubility while the lipidic character of the formulation facilitates permeation..

Objectives:
Objectives:

• To develop a new method of preparation of lipidic nanoparticles

• To apply Quality by design and risk-based approach to find variables

• To optimize variables and find the design space

• To evaluate and characterize the optimized formulation

Methods:
The present study is an attempt to address the challenges in the formulation of NLCs us-ing a high-speed homogenizer. Quality by Design approach was used to find the material attributes and process parameters playing a significant role in the formulation development. Quality Target product profile was prepared, and failure mode and effect analysis was performed for a better un-derstanding of the risks, ways to alleviate risks, and finally, to propose a control strategy. The for-mulation was optimized by using 3-levels 3-factors central composite design, and design space was obtained by using graphical optimization. The morphology of the particles was studied by using Transmission Electron Microscope. In vitro drug release study was performed using Franz diffusion cell.

Results:
The amount of solid lipid, solid lipid to total lipid ratio, and concentration of surfactant were found to be high risk variables and their effects on the product quality were examined using Central composite design considering particle size, particle size distribution and %entrapment efficiency as dependent variables. Optimized NLC had a particle size of 72.58 nm with PDI 0.137 and %entrapment efficiency of 78.79%. The in vitro drug release study showed sustained drug release over the period of 24 hrs and followed the Higuchi model with a fickian diffusion mecha-nism.

Conclusion:
The present study successfully explored QbD along with Risk-based approach for the development of voriconazole containing lipidic nanoparticles.
A Convolution Neural Network-based Approach for Metal Surface
Roughness Evaluation
Authors: Pan Zengren , Liu Yanhui , Li Zhiwei , Xun Qiwen , Wu Ying 
Published: April 2023

Background:
Metal surface roughness detection is an essential step of quality control
in the metal processing industry. Due to the high manual involvement and poor efficiency of traditional
roughness testing, rapid automated vision detection has received increasing attention in
product quality control. Many methods have focused on extracting features related to roughness
from images by means of mathematical statistics. However, these methods often rely on extensive
experiments and complex calculations, while being sensitive to external environmental disturbances.

Methods:
In this paper, a convolution neural network-based approach for metal surface roughness
evaluation has been proposed. The convolutional neural network was initialized using a transfer
learning strategy, and the data augmentation technique was applied to the benchmark dataset for
sample expansion.

Results:
To evaluate this approach, samples of 4 types of roughness classes were prepared. The
samples were divided into a training set, validation set, and test set in the ratio of 7:2:1. The accuracy
of the neural network on the test set was found to be above 86%.

Conclusion:
The effectiveness of the proposed approach and its superiority over manual detection
have been demonstrated in the experiments.
Biomaterials in Medical Applications
Authors: yadav Sonia , Varghese Sruthy , Devi Reena , Kumar Davinder , Khatri Naveen , Singh Gajendra , Kumar Virender 
Published: April 2023

Abstract:
Biomaterials, a fascinating and highly interdisciplinary field, have become integral to
improving modern man's conditions and quality of life. It is done by many health-related problems
arising from many sources. The first batch of biomaterials was produced as implants and
medical equipment in the 1960s and 1970s. Biomaterials are primarily used in medicine and may
be directly or indirectly exposed to biological systems. For instance, we could use them in cultures
and mediums for cell development, plasma protein testing, biomolecular processing cultures,
diagnostic gene chips, and packaging materials primarily for medical items. Biomaterials
should have certain qualities for human-related problems, like being non-carcinogenic, not being
pyrogenic or toxic, completely plasma compatible, and anti-inflammatory. This paper introduces
the history, classification, and ideal parameters of biomaterials and where they are used in the
current scenarios in the medical field, providing a brief outlook on the future.
Monitoring the Diversity of Amphibian and Reptiles In the Upstream part of Code River Using e-DNA Method
Authors: Yudha Donan Satria , Izzati Rahma , Ardianto Aulia Sigit , Nainggolan Ananto Puradi , Priyono Dwi Sendi 
Published: April 2023

Research on the diversity of amphibians and reptiles on the upstream part of Code River had been done in 2012 and 2017. Result on two previous results were found anurans, snakes and lizards but we did not find any freshwater turtles. Method used on the 2012 and 2017 research was conventional using Visual Encounter Survey (VES). Conventional methods such as VES have limitations, which was the inability to detect difficult-to-find animals such as freshwater turtles. Therefore, a new approach was taken to monitor the diversity of amphibians and reptiles especially to detect freshwater turtles in the Code River, namely the environmental DNA (eDNA) method. The purpose of this research were to monitor the diversity of amphibians and reptiles, and to reveals eDNA sampling efficiency compared to VES. An e-DNA metabarcoding process is conducted with universal CO1 primer on the water sample taken from upstream part of Code River. The results obtained were compared to the data from conventional studies held in 2012 and 2017. The results in 2021 found 12 species of amphibians but all of these species did not naturally distribute in Yogyakarta and even in Indonesia. Furthermore, 5 species of snakes were found, with only 1 species of snake naturally occur in Yogyakarta. Subsequently, we found 6 species of lizards whose natural distribution does not exist in Yogyakarta and even in Indonesia. Finally, we obtained 1 species of tortoise whose natural distribution does not exist in Yogyakarta and even in Indonesia. By far, in Indonesia the identification of amphibian and reptile species in rivers using the e-DNA method has shown less accurate results. The inaccuracy may be due to the lack of specificity of the sequence targets and primers for monitoring reptiles and amphibians in rivers. The target sequences used in this study did not have significant differences between species in reptiles and amphibians, so that the herpetofauna that had been recorded in the Code River were not identified using the e-DNA method. Based on this research, conventional sampling is recommended for monitoring herpetofauna in river areas.
Keywords: Monitoring, Amphibians; Reptiles; Code River, e-DNA
Русские места памяти в современном Харбине: имперские смыслы и советские символы
Authors:   Banzarov Buryat State University (24A, Smolin St., 670000 Ulan-Ude, Russian Federation), Mikhalev Alexey V.  
Published: April 2023

Introduction. The study analyzes Russian places of memory in contemporary Harbin. Goals. The paper seeks to answer the question if a memorial consensus regarding the Russian heritage in China is possible, the term ‘memorial consensus’ as such denote a certain formal or informal agreement — between governments or within the community — whether to accept or reject certain symbols of the past, and how to interpret the historical events. That would guarantee conflict-free attitudes to places of memory and their due use for ritual purposes. Moreover, such an agreement regulates how certain memorials or memorable dates associated with a common history may be used in a way most acceptable to all the parties. And the present-day war on monuments around the world makes the study timely enough. In this regard, the Chinese experiences of forming a model for accepting a common past are of essential interest. Materials and methods. Methodologically, the work clusters with memory studies. The paper relies on the concepts ‘places of memory’ and ‘cultural memory’ to apply them to empirical materials of Heilongjiang and focus on toponyms, monuments, cemetery, museum exhibitions, architectural monuments, including Orthodox Christian churches. The discussion shall comprise not only monuments associated with White Russian émigrés but also later Soviet memorials. The paper investigates topographic data, visual materials, reference books dealing with historical and cultural landscapes, and historical works. Discussion. In terms of academic disciplines, the study involves historical, political science, sociological, and cultural approaches. This makes it possible to combine the analysis of the position of memorial objects with political changes in the region. Results. The work shows that a memorial consensus about the ‘Russian past’ has been formed in Harbin to meet tourist needs within the city’s image. This has been facilitated by the rapid development of domestic tourism in China. An important role in finding a memorial consensus was played by the constant dialogue between leaders of the two countries. The study identifies a total of three periods when relationships between national leaders had positive impacts on the policy towards the past. The first period is the time of the union between I. V. Stalin and Mao Zedong, the second period is the dialogue between B. N. Yeltsin and Jiang Zemin, and the third one is the tandem of V. V. Putin and Xi Jinping.
Переводческая и издательская деятельность Астраханского епархиального комитета Православного миссионерского общества (по материалам Государственного архива Астраханской области)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Kurapov Andrey A. 
Published: April 2023

Introduction. The article introduces into scientific circulation a set of documents contained in Collection 597 — ‘Astrakhan Diocesan Committee of the Missionary Orthodox Society’ — of the State Archive of Astrakhan Oblast to examine translation and publishing activities of Orthodox missionaries in Kalmyk Steppe during the 19th – early 20th centuries. Materials and methods. The method of comparative historical analysis proves instrumental in investigating unpublished archival files from Collection 597 of Astrakhan Oblast’s Archive dealing with translation and publishing endeavors of Astrakhan Diocesan Committee during the mentioned period, namely: reports by individual missionaries, annual activity reports of the Committee, interdepartmental correspondence, correspondence of the Committee with regional branches of Orthodox Missionary Society, Kazan Theological Academy and its representatives sent to Kalmyk Steppe, Translation Commission affiliated to the Orthodox Christian Brotherhood of St. Gury, the Holy Synod, and Russian academic Mongolists K. Golstunsky and A. Pozdneev. Results. The paper introduces documents covering the main stages in translation and publishing activities of Astrakhan Diocesan Committee during the 19th – early 20th centuries. Conclusions. The study of the documents discovered in Collection 597 makes it possible to consider translation and publishing activities of the Committee members in their evolution, interregional interaction between missionary committees aimed at exchanging and clarifying Kalmyk translations of Orthodox Christian texts, identify impacts of the Holy Synod into the mentioned processes, including those made by teachers of Kazan Theological Academy, St. Petersburg University, and outstanding Russian Mongolists.
Подарки и их смыслы в деятельности Монголо-тибетской экспедиции П. К. Козлова (1923–1926 гг.) (по новым архивным документам)
Authors:   Vavilov Institute for the History of Science and Technology of the RAS, St. Petersburg Branch (5, Universitetskaya Emb., 199034 St. Petersburg, Russian Federation), Yusupova Tatiana I. 
Published: April 2023

Introduction. The article examines gift donations practiced during the 1923–1926 expedition to Mongolia and Tibet led by the outstanding Russian explorer of Central Asia Pyotr K. Kozlov. Goals. The paper seeks to analyze items approved by the Soviet Government for P. Kozlov to have selected from the State Depositary, reasons why the traveler did receive the precious artifacts of gold and silver, circumstances of donations, addressees, and the latter’s perceptions. Materials and methods. The work focuses on materials from the State Archive of the Russian Federation and P. Kozlov’s expedition diaries, the objectives set be articulated via individual gift donation stories (occasions) with Mongolian elites and the 13th Dalai Lama, corresponding motives and offering forms. Results. The paper shows the gift-giving practices were viewed by the traveler not only as some homage be paid to local cultures but rather as a means of communication with Mongolian officials and authorities for the latter’s assistance in solving problems faced by the Expedition. No other Russian explorer ever delivered such high-value items to have been used as gifts. Conclusions. This suggests the Bolshevik Government was hoping — with the help of Kozlov’s expedition — to facilitate positive images of Soviet Russia in Mongolia and Tibet (during a scheduled meeting with the Dalai Lama). The Appendix to the article includes several documents from the State Archive of Russia describing the selected gifts and their distribution by individuals.
Functional connectivity of brain structures in patients with anorexia nervosa based on resting state fMRI: prospective study
Authors: Grebenshchikova R. V. , Ananyeva N. I. , Pichikov A. A. , Iskhakov D. N. , Lukinа L. V. 
Published: April 2023

INTRODUCTION: This paper analyzes local and foreign literature on functional magnetic resonance imaging (fMRI) in patients with anorexia nervosa. Resting state fMRI results of the brain of patients with anorexia nervosa (AN) are presented.OBJECTIVE: To study functional connectivity in the networks in resting state in patients with AN.MATERIALS AND METHODS: 43 patients with anorexia nervosa aged 14 to 19 years were examined. The control group consisted of 31 healthy volunteers. The connectivity of the structures involved in the formation of the default mode brain network, frontoparietal and visual networks was analyzed. Statistics: Mathematical and statistical processing was applied in the programming environment of the Python programming language, using the Jupyter-notebook development environment and application modules for statistical analysis Pandas and Numpi. The main tools for statistical analysis of functional MRI were the specialized software package CONN-TOOLBOX.RESULTS: In the default mode network, a decrease in connectivity between the medial prefrontal cortex and the cluster including the angular gyrus and the supramarginal gyrus, and an increase in connectivity between the right lateral parietal cortex and the cluster including the left precentral and postcentral gyrus, were revealed. In the frontoparietal network, significant indicators of a decrease in connectivity between the right lateral prefrontal cortex and three clusters were obtained, including the poles of the frontal lobes, the left superior and middle frontal gyri, and the left lateral occipital cortex. In the visual network, there was a decrease in connectivity between the left lateral visual network and the cluster which includes mainly the lateral parts of the cerebellar hemispheres and its vermis, the right lateral visual network and the cluster which includes mainly the right and left lingual gyrus, cerebellar hemispheres and vermis.CONCLUSION: Our study showed a disruption of the functional connectivity in patients with AN, leading to visuospatial disorders and, as a result, a change in the complex process of setting goals, planning appropriate steps to these goals, and impaired cognitive control.
Ultrathin Partial Ceramic Veneers in the Esthetic Zone with Tooth Whitening: A 5-year Case Report
Authors: Villalobos-Tinoco JV , Fischer NG , Jurado CA , Flores-Reyes J , Karimi K , Tsujimoto A 
Published: April 2023

SUMMARY

Objective:
This case report describes a minimally invasive approach with tooth whitening and partial ceramic veneers in the esthetic zone with a 5-year follow-up.

Clinical considerations:
The patient was initially concerned about the tooth color and previous direct resin composite restorations that chipped on the incisal edges of both maxillary central incisors. Tooth whitening and partial veneers for both central incisors were recommended after clinical evaluation. Two sessions of in-office tooth whitening, first with 35% hydrogen peroxide and later with 10% carbamide peroxide from first premolar to first premolar, were provided. Minimal tooth preparation that only removed the fractured composite restorations was performed followed by placement of feldspathic porcelain ultrathin partial ceramic veneers for both central incisors. We emphasize the benefits of minimal tooth preparation paired with partial ceramic veneers and the importance of masking discolored tooth structure with such thin veneers, including potential tooth whitening.

Conclusions:
Overall, we demonstrate a well-planned and executed restorative procedure combining tooth whitening and ultrathin partial ceramic veneers to achieve desired results in the esthetic zone that remained successful for five years.
Arbeidsinnvandring og lokalsamfunn – stedsidentiteter mellom kontinuitet og endring
Authors: Stachowski Jakub , Rasmussen Bente 
Published: April 2023

In this chapter, we explore attitudes, practices, and reactions to labour migration among stakeholders in two rural communities located by the Norwegian coast. Using qualitative in-depth interviews, we explore what the local narratives reveal about how labour migration affects the social dynamics of rural communities and understandings of local place identities.
The analyzed cases illustrate two different ways of responding to and incorporating the migrants, and how these approaches are related to perceptions and understandings of the communities themselves. In the first case, increasing labour migration fits into the community’s narrative of place as open and cosmopolitan, with a long tradition of extra-local impulses and connections, as well as a current, ongoing transformation of the area. Thus, international migration appears to be an integral part of the local place identity. In the second case, the impact of migration is more profound, and the narrative more ambiguous. On the one hand, migrants are appreciated for how they stimulate the local community; on the other hand, their perceived impact is experienced as substantial, and the narratives reveal expectations of assimilation. Our analysis indicates a context-dependent variation of how international migration is viewed in different rural communities, and that increasing diversity may be accompanied by emerging social divisions.