bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe drilling zones for anteriorly, central, and posteriorly angulated syndesmotic stabilization devices
Authors: Baumbach S. F. , Synek A. , Spindler F. T. , Bauer L. , Böcker W. , Polzer H. 
Published: December 2022

Abstract
Purpose
The purposes of the study were to (1) analyze the shape of the distal fibula at the location of syndesmotic stabilization and to (2) define safe zones at the distal-lateral fibula for three different drilling tunnel orientations: anteriorly-, posteriorly angulated and center-center.

Methods
Postoperative, bilateral CT images of adult patients that underwent syndesmotic stabilization (suture-button system) for an acute, unilateral ankle injury were analyzed. Manual axial CT reconstructions of the uninjured side were generated. First, the axial shape of the distal fibula was classified. The aspect ratio between the anterio-lateral and the posterior-lateral surfaces of the fibula was calculated to assess symmetry. Second, the same axial planes were used to define the safe zones. Each drilling-tunnel orientation (anterior, central, posterior) comprised a fixed medial tibial anchor point and a safe zone on the lateral fibula. For each of the three orientations, the most anteriorly and posteriorly drilling tunnel location was simulated. Next to a cumulative visual analysis, a quantitative analysis of the most anterior and posterior point on the anterio- and posterior-lateral surfaces was calculated.

Results
A total of 96 CT datasets were analyzed. (1) 81% of fibulae revealed a triangular convex-, 10% an irregular-, and 8% a quadrilateral shape. The lateral surface ratio was 1.0 ± 0.2 (range: 0.7–1.5), not differing between the fibula types (n.s.). (2) The safe corridor on the lateral surface of the fibula for an anteriorly angulated drilling tunnel was − 8% to − 41%, for a posteriorly angulated drilling tunnel was 0% to 46%, and for a center-center alignment − 7 ± 11% (range: − 28 to 18%).

Conclusion
The meta-diaphyseal region of the distal fibula revealed a homogeneous crosssectional shape. The lateral apex of the fibula can serve as a landmark defining safe zones to place the drilling tunnels correctly. Applying these safe zones in clinical practice could help to avoid the misplacement of the syndesmotic fixation device.

Level of evidence
Level III, retrospective radiographic study.
The effect of root hairs on exudate composition: a comparative non-targeted metabolomics approach
Authors: Lohse Martin , Santangeli Michael , Steininger-Mairinger Teresa , Oburger Eva , Reemtsma Thorsten , Lechtenfeld Oliver J. , Hann Stephan 
Published: December 2022

AbstractRoot exudation is a major pathway of organic carbon input into soils. It affects soil physical properties, element solubility as well as speciation, and impacts the microbial community in the rhizosphere. Root exudates contain a large number of primary and secondary plant metabolites, and the amount and composition are highly variable depending on plant species and developmental stage. Detailed information about exudate composition will allow for a better understanding of exudate-driven rhizosphere processes and their feedback loops. Although non-targeted metabolomics by high-resolution mass spectrometry is an established tool to characterize root exudate composition, the extent and depth of the information obtained depends strongly on the analytical approach applied. Here, two genotypes of Zea mays L., differing in root hair development, were used to compare six mass spectrometric approaches for the analysis of root exudates. Reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography combined with time-of-flight mass spectrometry (LC-TOF-MS), as well as direct infusion Fourier-transform ion cyclotron resonance mass spectrometry (DI-FT-ICR-MS), were applied with positive and negative ionization mode. By using the same statistical workflow, the six approaches resulted in different numbers of detected molecular features, ranging from 176 to 889, with a fraction of 48 to 69% of significant features (fold change between the two genotypes of > 2 and p-value < 0.05). All approaches revealed the same trend between genotypes, namely up-regulation of most metabolites in the root hair defective mutant (rth3). These results were in agreement with the higher total carbon and nitrogen exudation rate of the rth3-mutant as compared to the corresponding wild-type maize (WT). However, only a small fraction of features were commonly found across the different analytical approaches (20–79 features, 13–31% of the rth3-mutant up-regulated molecular formulas), highlighting the need for different mass spectrometric approaches to obtain a more comprehensive view into the composition of root exudates. In summary, 111 rth3-mutant up-regulated compounds (92 different molecular formulas) were detected with at least two different analytical approaches, while no WT up-regulated compound was found by both, LC-TOF-MS and DI-FT-ICR-MS. Zea mays L. exudate features obtained with multiple analytical approaches in our study were matched against the metabolome database of Zea mays L. (KEGG) and revealed 49 putative metabolites based on their molecular formula.
Graphical Abstract
Development and validation of a [18F]FDG PET/CT-based radiomics nomogram to predict the prognostic risk of pretreatment diffuse large B cell lymphoma patients
Authors: Li Mingshan , Yao Hongyang , Zhang Peng , Zhang Lingbo , Liu Wei , Jiang Zhiyun , Li Wei , Zhao Shu , Wang Kezheng 
Published: December 2022

AbstractObjectiveIn this study, based on PET/CT radiomics features, we developed and validated a nomogram to predict progression-free survival (PFS) for cases with diffuse large B cell lymphoma (DLBCL) treated with immunochemotherapy.MethodsThis study retrospectively recruited 129 cases with DLBCL. Among them, PET/CT scans were conducted and baseline images were collected for radiomics features along with their clinicopathological features. Radiomics features related to recurrence were screened for survival analysis using univariate Cox regression analysis withp< 0.05. Next, a weighted Radiomics-score (Rad-score) was generated and independent risk factors were obtained from univariate and multivariate Cox regressions to build the nomogram. Furthermore, the nomogram was tested for their ability to predict PFS using time-dependent receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).ResultsBlood platelet, Rad-score, and gender were included in the nomogram as independent DLBCL risk factors for PFS. We found that the training cohort areas under the curve (AUCs) were 0.79, 0.84, and 0.88, and validation cohort AUCs were 0.67, 0.83, and 0.72, respectively. Further, the DCA and calibration curves confirmed the predictive nomogram’s clinical relevance.ConclusionUsing Rad-score, blood platelet, and gender of the DLBCL patients, a PET/CT radiomics-based nomogram was developed to guide cases’ recurrence risk assessment prior to treatment. The developed nomogram can help provide more appropriate treatment plans to the cases.Key Points• DLBCL cases can be classified into low- and high-risk groups using PET/CT radiomics based Rad-score.• When combined with other clinical characteristics (gender and blood platelet count), Rad-score can be used to predict the outcome of the pretreatment of DLBCL cases with a certain degree of accuracy.• A prognostic nomogram was established in this study in order to aid in assessing prognostic risk and providing more accurate treatment plans for DLBCL cases.
Warming of Baltic Sea water masses since 1850
Authors: Dutheil C. , Meier H. E. M. , Gröger M. , Börgel F. 
Published: December 2022

AbstractThe Baltic Sea is among the fastest-warming seas globally in recent decades affecting biogeochemical conditions such as euxinic areas but also pelagic and benthic marine ecosystems. It is therefore crucial to understand how this heat gain is distributed vertically. We used reconstructed atmospheric forcing fields for 1850–2008 to perform an ocean climate simulation that adequately captures climatogical temperature and salinity profiles. Then, a water mass classification distinguishes three water masses corresponding to the classical view, warm and fresh surface waters, cold and fresh intermediate waters, and cold and salty bottom waters, and two transition water masses. The temperature trends show a similar three layers pattern with fast warming at the surface (~ 0.06 K decade− 1) and bottom (> 0.04 K decade− 1) and slow in the intermediate layers (< 0.04 K decade− 1). The slow warming in the intermediate layer is explained by both weakly warmed water winter convection and the summer surface thermocline isolating the intermediate layers. The warming in the deep layers is related to warm surface inflow from the North Sea and Baltic proper in the southern and northern Baltic Sea respectively. Furthermore, sensitivity experiments show that the warming magnitude is controlled by rising air temperature while the vertical distribution of heat gain is related to surface wind conditions. Finally, the North Atlantic Oscillation and Atlantic Multidecadal Oscillation are well correlated with the temperature minimum and thus modulate the magnitude of warming in the intermediate layers on shorter time scales. This study provides a new picture of the Baltic Sea’s warming and suggests that this complexity is essential for understanding the influence of climate change on marine ecosystems.
Stabbed by motorcycle? Reconstruction of an unusual traffic accident
Authors: Muggenthaler Holger , Bismann Daniel , Autsch Angelina , Hubig Michael , Subramaniam Jayant Shanmugam , Mall Gita , Wittschieber Daniel 
Published: December 2022

Abstract
The reconstruction of traffic accidents involving powered two-wheelers (PTWs) frequently proves to be a challenging task. A case in which a fatal head-on crash of a PTW with a small truck where only minor vehicles damage was observed but resulted in isolated fatal chest trauma is discussed here. External examination of the corpse revealed two lacerations on the back, at the first glance implying sharp trauma. Based on the accident traces, the technical expert assumed an emergency break of the PTW rider resulting in a rotation of the PTW in terms of a wheelie on the front wheel. The first contact between the PTW rider and the tail end of the small truck probably occurred with the upper side of the helmet, and then, the back handle of the PTW caused the stab-like injuries followed by compression of the rider between the small truck or asphalt and the PTW. Based on the few accident traces available, neither a reconstruction of the pre-impact velocity nor a detailed reconstruction of the PTW rider kinematics was possible. However, using an interdisciplinary approach, the principal collision position as well as the injury mechanisms could be reconstructed.
Impact of the glutamatergic neurotransmission within the A5 region on the cardiorespiratory response evoked from the midbrain dlPAG
Authors: González-García M. , Carrillo-Franco L. , Peinado-Aragonés C. A. , Díaz-Casares A. , Gago B. , López-González M. V. , Dawid-Milner M. S. 
Published: December 2022

Abstract
Stimulation of the dorsolateral periaqueductal grey matter (dlPAG) in rats evokes an active defensive behaviour together with a cardiorespiratory response characterised by tachypnoea, tachycardia and hypertension. The dlPAG neurons involved in these responses are excitatory, presumably glutamatergic, due to the presence of vesicular glutamate transporter VGLUT2 within their axon terminals. Previously, our group described a functional interaction between dlPAG and the pontine A5 region. Accordingly, in the present work, in order to characterize the role of glutamate within this interaction, experiments were carried out in spontaneously breathing anaesthetized rats (sodium pentobarbitone 60 mg/kg i.p., suplemented with 20 mg/kg i.p.). The cardiorespiratory response evoked by electrical stimulation of the dlPAG (1 ms pulses, 20–50 μA, given at 100 Hz, during 5 s) was analysed before and after the microinjection, within the A5 region, of either kynurenic acid (non-specific glutamate receptor antagonist; 5–10 nmol), DAP-5 (NMDA antagonist; 1 pmol), CNQX (non-NMDA antagonist; 1 pmol) or MCPG (metabotropic antagonist; 0,1 nmol). Kynurenic acid decreased the intensity of both the tachypnoea (p < 0,001) and tachycardia (p < 0,001) induced by dl-PAG stimulation. Blockade of no-NMDA receptors reduced the increase of respiratory frequency, heart rate and pressor response to dl-PAG stimulation (p < 0,01, p < 0,001, p < 0,05 respectively). Blockade of either NMDA or metabotropic receptors reduced the dlPAG-evoked tachycardia and pressor response (p < 0,01; p < 0,05 respectively). These results suggest a neuromodulatory role for A5 region via glutamate neurotransmission of the dlPAG-evoked cardiorespiratory response, confirming the role of the ventrolateral pons in the neuronal circuits involved in respiratory and heart rate control.
Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell–derived factors
Authors: Smith Emily J. , Beaumont Ross E. , McClellan Alyce , Sze Cheryl , Palomino Lago Esther , Hazelgrove Liberty , Dudhia Jayesh , Smith Roger K. W. , Guest Deborah J. 
Published: December 2022

AbstractTendon injuries occur commonly in both human and equine athletes, and poor tendon regeneration leads to functionally deficient scar tissue and an increased frequency of re-injury. Despite evidence suggesting inadequate resolution of inflammation leads to fibrotic healing, our understanding of the inflammatory pathways implicated in tendinopathy remains poorly understood, meaning successful targeted treatments are lacking. Here, we demonstrate IL-1β, TNFα and IFN-γ work synergistically to induce greater detrimental consequences for equine tenocytes than when used individually. This includes altering tendon associated and matrix metalloproteinase gene expression and impairing the cells’ ability to contract a 3-D collagen gel, a culture technique which more closely resembles the in vivo environment. Moreover, these adverse effects cannot be rescued by direct suppression of IL-1β using IL-1RA or factors produced by BM-MSCs. Furthermore, we provide evidence that NF-κB, but not JNK, P38 MAPK or STAT 1, is translocated to the nucleus and able to bind to DNA in tenocytes following TNFα and IL-1β stimulation, suggesting this signalling cascade may be responsible for the adverse downstream consequences of these inflammatory cytokines. We suggest a superior approach for treatment of tendinopathy may therefore be to target specific signalling pathways such as NF-κB.
Recent developments in parrot cognition: a quadrennial update
Authors: Rössler Theresa , Auersperg Alice M. 
Published: December 2022

AbstractPsittacines, along with corvids, are commonly referred to as ‘feathered apes’ due to their advanced cognitive abilities. Until rather recently, the research effort on parrot cognition was lagging behind that on corvids, however current developments show that the number of parrot studies is steadily increasing. In 2018, M. L. Lambert et al. provided a comprehensive review on the status of the most important work done so far in parrot and corvid cognition. Nevertheless, only a little more than 4 years after this publication, more than 50 new parrot studies have been published, some of them chartering completely new territory. On the 25th anniversary of Animal Cognition we think this warrants a detailed review of parrot cognition research over the last 4 years. We aim to capture recent developments and current trends in this rapidly expanding and diversifying field.
Supermodularity and valid inequalities for quadratic optimization with indicators
Authors: Atamtürk Alper , Gómez Andrés 
Published: December 2022

AbstractWe study the minimization of a rank-one quadratic with indicators and show that the underlying set function obtained by projecting out the continuous variables is supermodular. Although supermodular minimization is, in general, difficult, the specific set function for the rank-one quadratic can be minimized in linear time. We show that the convex hull of the epigraph of the quadratic can be obtained from inequalities for the underlying supermodular set function by lifting them into nonlinear inequalities in the original space of variables. Explicit forms of the convex-hull description are given, both in the original space of variables and in an extended formulation via conic quadratic-representable inequalities, along with a polynomial separation algorithm. Computational experiments indicate that the lifted supermodular inequalities in conic quadratic form are quite effective in reducing the integrality gap for quadratic optimization with indicators.
Hydrocephalus, cerebral vasospasm, and delayed cerebral ischemia following non-aneurysmatic spontaneous subarachnoid hemorrhages: an underestimated problem
Authors: Wolfert Christina , Maurer Christoph J. , Berlis Ansgar , Schneider Hauke , Steininger Kathrin , Motov Stefan , Krauss Philipp , Sommer Björn , Shiban Ehab 
Published: December 2022

Abstract
Non-aneurysmal subarachnoid hemorrhage (NASAH) is rare and mostly benign. However, complications such as cerebral vasospasm (CV), delayed cerebral ischemia (DCI), or post-hemorrhagic hydrocephalus (HC) may worsen the prognosis. The aim of this study was to evaluate the rate of these complications comparing perimesencephalic (PM) and non-perimesencephalic (NPM) SAH. Monocentric, retrospective analysis of patients diagnosed with NASAH from 01/2010 to 01/2021. Diagnosis was set only if vascular pathologies were excluded in at least one digital subtraction angiography, and NASAH was confirmed by cranial computed tomography (cCT) or lumbar puncture (LP). One hundred patients (62 female) with a mean age of 54.9 years (27–84) were identified. Seventy-three percent had a World Federation of Neurological Surgeons (WFNS) grading scale score I, while 9% were WFNS score IV or V at the time of admission. SAH was diagnosed by cCT in 86%, in 14% by lumbar puncture. Twenty-five percent necessitated short-term CSF diversion by extraventricular drainage or lumbar drainage, whereof 7 suffered from long-term HC treated with ventriculoperitoneal shunting (VPS). One patient without a short-term CSF drainage developed long-term HC. Ten percent developed CV, four of whom received intraarterial spasmolysis. Radiological DCI was diagnosed in 2%; none of these correlated with CV. Despite a mortality of 3% occurring solely in NPM SAH, the analyzed complication rate was comparable in both groups. We observed post-hemorrhagic complications in 35% of cases during the first 3 weeks after bleeding, predominantly in patients with NPM SAH. For this reason, close observation and cranial imaging within this time may be indicated not to overlook these complications.
Forced Frequency Locking for Semilinear Dissipative Hyperbolic PDEs
Authors: Kmit Irina , Recke Lutz 
Published: December 2022

AbstractThis paper concerns the behavior of time-periodic solutions to 1D dissipative autonomous semilinear hyperbolic PDEs under the influence of small time-periodic forcing. We show that the phenomenon of forced frequency locking happens similarly to the analogous phenomena known for ODEs or parabolic PDEs. However, the proofs are essentially more difficult than for ODEs or parabolic PDEs. In particular, non-resonance conditions are needed, which do not have counterparts in the cases of ODEs or parabolic PDEs. We derive a scalar equation which answers the main question of forced frequency locking: Which time shifts $$u(t+\varphi )$$

u
(
t
+
φ
)

of the solution u(t) to the unforced equation do survive under which forcing?
Surgical Technique and Efficacy Analysis of Extra-pseudocapsular Transnasal Transsphenoidal Surgery for Pituitary Microprolactinoma
Authors: Wan Xue-yan , Li Lin-han , Chen Juan , Wang Jun-wen , Liu Yan-chao , Huang Yi-min , Shu Kai , Buchfelder Michael , Fahlbusch Rudolf , Lei Ting 
Published: December 2022

Abstract
Objective
To elucidate the role of transsphenoidal surgery in the treatment of pituitary microprolactinoma.

Methods
The clinical data of 107 prolactinoma cases treated by extra-pseudocapsular transnasal transsphenoidal surgery (ETTS) for different indications in our department since 2011 was retrospectively analyzed.

Results
The most common indication was the ineffectiveness of oral medication (41.1%), followed by the personal willingness of the patient (35.5%), and 20.6% of the patients were young women with clear tumor boundaries. The pseudocapsule was not observed in 63 cases (58.9%), incomplete pseudocapsule was observed in 26 cases (24.3%), and complete pseudocapsule in 18 cases (16.8%). A total of 97 patients (90.7%) obtained 1-year post-operation remission. According to the relative location of the adenoma and pituitary gland on the MRI scan, 46 patients were classified into a central type, 59 a lateral type, and 2 a supra-pituitary type. Two patients developed hypogonadism, one patient developed hypocortisolism, and one patient developed post-operative hypothyroidism. Two patients were administrated with hormone replacement treatment, and the treatment was stopped within one week. There was no permanent hypopituitarism. Further investigation demonstrated that the adenoma types could affect the remission rates of hyperprolactinemia and gross total resection rate in microprolactinoma.

Conclusion
ETTS was an effective treatment for pituitary microprolactinomas. This could be the first choice for patients who presented enclosed adenoma on the MRI and were potentially curable in a preoperative evaluation. Maximal safe removal of the adenoma by ETTS with the aim to increase the sensitivity of the drugs was also recommended for patients with invasive dopamine agonist resistant prolactinomas and patients with difficulty in childbirth.
Experimental assessment of wing lower surface buffet effects induced by the installation of a UHBR nacelle
Authors: Sebastian Spinner , Ralf Rudnik 
Published: December 2022

AbstractThe installation of large bypass ratio engines on classical under wing configurations may lead to shock/boundary layer interaction on the wing lower surface, limiting the flight envelope in a similar way to classical buffet occurring on the wing suction side at high incidences in transonic flight. In this study, buffet effects on the lower surface of the wing induced by the installation of a Ultra-High-Bypass-Ratio through flow nacelle are assessed by means of wind tunnel testing. Unsteady pressure sensitive paint measurements were used to assess the pressure field on the wing with high temporal and spatial resolution. Strong unsteady shock motion associated with shock induced separation was found on the wing lower surface for various combinations of Mach number, Reynolds number and angle of attack. The wing lower surface buffet effects are found to increase with reducing angle of attack and are present over a wide range of Reynolds numbers. Preliminary spectral analysis suggests an upper limit for the buffet frequency at a Strouhal number of about 0.4.