bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MEITIM project and the development of future competencies in higher education in the mining industry
Authors: Gogolewska A B , Szostak K , Worsa-Kozak M 
Published: January 2023

Abstract
In recent years, the raw materials industry has focused on digitization and automation and on the implementation of concepts such as Industry 4.0, smart mines, etc. However, higher education does not offer a master’s program that includes the integration technologies and entrepreneurship for the development of professionals needed by the raw materials industry to increase its competitiveness. The International Project Master in Entrepreneurship, Innovation, and Technology Integration in Mining (MEITIM), which is co-financed by EIT Raw Materials, aims to create a new Master program in Entrepreneurship, Innovation, and Integration of various technologies in mining. The Master’s program is the result of a four-year collaboration between the Technical University of Madrid (UPM), the Lappeenranta-Lahti University of Technology (LUT), and the Wroclaw University of Science and Technology (WUST). The program aims to educate new technologists and entrepreneurs who understand the entire value chain related to the raw materials economy and are able to integrate new technologies with feasible and innovative business solutions with high impact and added value in the mining sector. The current educational opportunities in the mining sector and the results of the research of the labour market in the mining sector in Poland and selected EU countries are presented. The system of education in the fields of Mining and Geology in Poland, Spain and Finland is described. The project orientation and the goals of training an engineer for the mining of the future were defined.
Problems of Securing Drive Systems of Selected Mining Machines with Locking Assemblies
Authors: Kuczaj M , Flipowicz K , Buchcik A 
Published: January 2023

Abstract
The paper describes locking assemblies used i.a. in mining machines and discusses the advantages of their application. On the example of a roadheader and belt conveyor, the assembly, disassembly and operating problems connected to locking assemblies occurring in the conditions of underground exploitation of raw materials are presented. From the examples of the use of locking assemblies and the resulting problems presented in the paper, it can be concluded that their proper operation depends upon a maximum reduction of their contamination.
Fostering circular economy approach in extractive industry-related study programs – the CIRCEXTIN project
Authors: Lutyński M , Murphy M , Shogenov K , Shogenova A. , Wolf K-H , Soleymani Shishvan M , Ortega M F , García-Martínez M J , Mora P , Mazurek M 
Published: January 2023

Abstract
Extractive industry is an industry where large volumes of waste are generated. Solid waste from mining and quarrying is the second largest stream of waste in European Union. Extractive industry and higher education programs related to it such as mining, mineral engineering, raw materials, and applied earth sciences need to put an emphasis on this context and include this concept in the existing curricula and/or create new study programs or short courses that will include circular economy (CE) approach. In 2020 project CIRCEXTIN funded by the Erasmus+ Strategic partnerships Key Action 2 was started. The objective of this project is to create a strategic partnership between Universities and companies developing a comprehensive training platform that will help to modify existing study programmes related to the extractive industry and knowledge of proper waste management incorporating a circular economy approach. This article presents major assumptions and result of the project as of September 2022.
Fabrication of a single-crystal diamond neutron detector and its application in 14.1 MeV neutron detection in deuterium–tritium fusion experiments
Authors: XU Ping , YU Yi , ZHOU Haiyang 
Published: January 2023

Abstract
A single-crystal diamond detector is fabricated to diagnose 14.1 MeV deuterium–tritium (D-T) fusion neutrons. The size of its diamond film is 4.5 mm × 4.5 mm × 500 μm. This film is sandwiched by a flat, strip-patterned gold electrode. The dark current of this detector is experimentally measured to be lower than 0.1 nA under an electric field of 30 kV cm−1. This diamond detector is used to measure D-T fusion neutrons with a flux of about 7.5 × 105 s–1 cm–2. The pronounced peak with a central energy of 8.28 MeV characterizing the

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reaction in the neutron energy spectrum is experimentally diagnosed, and the energy resolution is better than 1.69%, which is the best result reported so far using a diamond detector. A clear peak with a central energy of 6.52 MeV characterizing the

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reaction is also identified with an energy resolution of better than 7.67%.
A generalized Bayes framework for probabilistic clustering
Authors: Rigon Tommaso , Herring Amy H , Dunson David B 
Published: January 2023

SummaryLoss-based clustering methods, such as k-means clustering and its variants, are standard tools for finding groups in data. However, the lack of quantification of uncertainty in the estimated clusters is a disadvantage. Model-based clustering based on mixture models provides an alternative approach, but such methods face computational problems and are highly sensitive to the choice of kernel. In this article we propose a generalized Bayes framework that bridges between these paradigms through the use of Gibbs posteriors. In conducting Bayesian updating, the loglikelihood is replaced by a loss function for clustering, leading to a rich family of clustering methods. The Gibbs posterior represents a coherent updating of Bayesian beliefs without needing to specify a likelihood for the data, and can be used for characterizing uncertainty in clustering. We consider losses based on Bregman divergence and pairwise similarities, and develop efficient deterministic algorithms for point estimation along with sampling algorithms for uncertainty quantification. Several existing clustering algorithms, including k-means, can be interpreted as generalized Bayes estimators in our framework, and thus we provide a method of uncertainty quantification for these approaches, allowing, for example, calculation of the probability that a data point is well clustered.
Enhanced recovery after surgery in children undergoing abdominal surgery: meta-analysis
Authors: Hidayah Bte Azahari , Toh Zheng An , Cheng Ling Jie , Syahzarin Bin Daud , Zhu Yi , Pölkki Tarja , He Honggu , Mali Vidyadhar Padmakar 
Published: January 2023

Abstract

Background
Enhanced recovery after surgery (ERAS) is a multimodal approach that streamlines patient processes before, during, and after surgery. The goal is to reduce surgical stress responses and improve outcomes; however, the impact of ERAS programmes in paediatric abdominal surgery remains unclear. The authors aimed to review the effectiveness of ERAS on clinical outcomes in children undergoing abdominal surgery.

Method
CINAHL, CENTRAL, Embase, ProQuest, PubMed, and Scopus were searched for relevant studies published from inception until January 2021. The length of hospital stay (LOS), time to oral intake, time to stool, complication rates, and 30-day readmissions were measured. Meta-analyses and subgroup analyses were conducted using RevMan 5.4 with a random-effects model.

Results
Among 2371 records from the initial search, 111 articles were retrieved for full-text screening and 12 were included for analyses. The pooled mean difference (MD) demonstrated reduced LOS (MD −1.96; 95 per cent c.i. −2.75 to −1.17), time to oral intake (MD −3.37; 95 per cent c.i. −4.84 to −1.89), and time to stool (MD −4.19; 95 per cent c.i. −6.37 to −2.02). ERAS reduced postoperative complications by half and 30-day readmission by 36 per cent. Subgroup analyses for continuous outcomes suggested that ERAS was more effective in children than adolescents.

Conclusion
ERAS was effective in improving clinical outcomes for paediatric patients undergoing abdominal surgery.
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation
Authors: Wang Shidong , Qiao Chen , Li Jun , Liu Si , Li Peng 
Published: January 2023

Abstract
Cancer susceptibility candidate 19 (CASC19) is a novel long non-coding RNA (lncRNA) that has been reported to implicate in the development and therapeutic resistance of various cancers. However, the biological functions and the underlying mechanisms of CASC19 in gastric cancer (GC) remain unclear. In this study, GC-related lncRNAs were screened by lnCAR-database analysis. Based on Gene Expression Profiling Interactive Analysis (GEPIA) database, GC survival analysis associated with CASC19 was carried out. Quantitative real-time PCR (qRT-PCR) and chromogenic in situ hybridization were adopted to determine the expression level of CASC19. 5-ethynyl-2ʹ-deoxyuridine (EdU) assay, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay and cell cycle assay were used to measure the proliferation capabilities of GC cells. Wound healing assay, transwell migration and invasion assay were performed to detect the metastatic ability of GC cells. Furthermore, subcellular fractionation assay, mass spectrometry, RNA pull-down, RNA immunoprecipitation, western blot and protein stability assay were conducted to investigate the mechanism of CASC19 in GC. Here, we report that CASC19 exerts an oncogenic effect on GC. CASC19 was found to be elevated in GC and overexpression of CASC19 was associated with advanced TNM (tumor node metastasis) stage and poor prognosis. Functionally, CASC19 knockdown inhibited GC cells proliferation, migration and invasion, and induced cell cycle arrest. Mechanistically, CASC19 interacted with cAMP response element-binding protein 1 (CREB1) and enhanced its stability by preventing its ubiquitin/proteasome-dependent degradation. In conclusion, these findings suggest that CASC19 may act as a cancer accelerator in GC by regulating CREB1 stability and highlight CASC19 as a potential biomarker and a valuable therapeutic target for advanced GC.
Skin morbidity in Indigenous children in relation to housing conditions in remote communities in Northwestern Ontario, Canada
Authors: Schreiber Yoko , Mallach Gary , Barrowman Nick , Tsampalieros Anne , Kelly Len , Gordon Janet , McKay Michael , Wong Carmen Liy , Kovesi Thomas 
Published: January 2023

Abstract

Background
Elevated rates of eczema and skin infections in Canadian First Nation (FN) communities are of concern to families, community leaders and healthcare professionals.

Aim
To determine whether skin morbidity was associated with indoor environmental quality factors in Canadian FN children living in remote communities.

Methods
We quantified indoor environmental quality (IEQ) in the homes of FN children aged &lt; 4 years of age living in four remote communities in the Sioux Lookout region of Northwestern Ontario, Canada. We conducted a quantitative housing inspection, including measuring surface area of mould (SAM), and monitored air quality for 5 days in each home, including carbon dioxide and relative humidity and quantified endotoxin in settled floor dust. We reviewed the medical charts of participating children for skin conditions and administered a health questionnaire. Relationships between IEQ and skin infections or eczema were evaluated using multivariable regression.

Results
In total, 98 children were included in the descriptive analyses, of whom 86 had complete data and were evaluated in multivariate analyses for dermatological outcomes (mean age 1.6 years). Of these 86 children, 55% had made ≥ 1 visits to the local health centre (HC) for skin and soft tissue infections and 25.5% for eczema. Unexpectedly, annualized eczema visits were inversely associated with SAM (RR = 0.14; 95% CI 0.01–0.93). There was a trend suggesting an inverse relationship between endotoxin and HC encounters for eczema and skin and soft tissue infections.

Conclusion
Skin infections were common in this population of FN children. IEQ did not appear to be associated with skin infections or eczema. Mould exposure appeared to be inversely associated with HC encounters for eczema, possibly related to complex microorganism–host interactions occurring early in life.
Mistuned NF-κB signaling in lymphocytes: lessons from relevant inborn errors of immunity
Authors: Dabbah-Krancher Gina , Snow Andrew L 
Published: January 2023

Summary
Inborn errors of immunity (IEIs) continuously remind us that multiple checks and balances are built into the adaptive immune system to maintain homeostasis, ensuring effective pathogen defense without causing inadvertent immunopathology, autoimmunity, or lymphomagenesis. The nuclear factor of κB (NF-κB) family of transcription factors serve a vital role in the immune system, inducing scores of genes responsible for lymphocyte survival, proliferation, differentiation and effector function. In recent years, the discovery and characterization of IEIs that impact NF-κB activity have illuminated the importance of carefully tuning this pathway to ensure effective immune defense without hyperinflammation and immune dysregulation. Here we examine several illustrative cases of IEIs that arise from pathogenic mutations encoding NF-κB inducers, regulators, and NF-κB family components themselves, illuminating how these genes ensure normal adaptive immune system function by maintaining a “Goldilocks effect” state in NF-κB pathway activity.
Jocasta’s last hours: identity, responsibility, and violence in Martha Graham’sNight Journey
Authors: Papathanasopoulou Nina 
Published: January 2023

AbstractThis paper analyses Martha Graham’s Night Journey in relation to its primary model, Sophocles’ Oedipus Tyrannos. Night Journey captivates us by drawing deeply on Sophocles’ original and invites us to turn our focus to the last hours of Jocasta’s life, a moment to which Sophocles’ play gives comparatively little attention. I argue that Graham’s focus on the last hours of Jocasta’s life brings fresh illumination to our interpretation of the Oedipus myth. I first discuss the dance’s narrative technique and then analyse three themes that are central to both Sophocles’ and Graham’s works: questions of identity; responsibility; and the deep-seated human urge toward violence in the face of anxiety. In each case I show how Graham transforms Sophocles’ treatment of these themes and explores them through the character of Jocasta and a chorus of women, making women the focus of the narrative’s meditations on the nature of identity, moral responsibility, and human emotion.
PTX3 from vascular endothelial cells contributes to trastuzumab-induced cardiac complications
Authors: Xu Zhifei , Gao Zizheng , Fu Huangxi , Zeng Yan , Jin Ying , Xu Bo , Zhang Yuanteng , Pan Zezheng , Chen Xueqin , Zhang Xiaochen , Wang Xiaohong , Yan Hao , Yang Xiaochun , Yang Bo , He Qiaojun , Luo Peihua 
Published: January 2023

Abstract

Aims
Trastuzumab, the first humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (ERBB2/HER2), is currently used as a first-line treatment for HER2 (+) tumours. However, trastuzumab increases the risk of cardiac complications without affecting myocardial structure, suggesting a distinct mechanism of cardiotoxicity.

Methods and results
We used medium from trastuzumab-treated human umbilical vein endothelial cells (HUVECs) to treat CCC-HEH-2 cells, the human embryonic cardiac tissue-derived cell lines, and human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) to assess the crosstalk between vascular endothelial cells (VECs) and cardiomyocytes. Protein mass spectrometry analysis was used to identify the key factors from VECs that regulate the function of cardiomyocytes. We applied RNA-sequencing to clarify the mechanism, by which PTX3 causes cardiac dysfunction. We used an anti-human/rat HER2 (neu) monoclonal antibody to generate a rat model that was used to evaluate the effects of trastuzumab on cardiac structure and function and the rescue effects of lapatinib on trastuzumab-induced cardiac side effects. Medium from trastuzumab-treated HUVECs apparently impaired the contractility of CCC-HEH-2 cells and iPSC-CMs. PTX3 from VECs caused defective cardiomyocyte contractility and cardiac dysfunction in mice, phenocopying trastuzumab treatment. PTX3 affected calcium homoeostasis in cardiomyocytes, which led to defective contractile properties. EGFR/STAT3 signalling in VECs contributed to the increased expression and release of PTX3. Notably, lapatinib, a dual inhibitor of EGFR/HER2, could rescue the cardiac complications caused by trastuzumab by blocking the release of PTX3.

Conclusion
We identified a distinct mode of cardiotoxicity, wherein the activation of EGFR/STAT3 signalling by trastuzumab in VECs promotes PTX3 excretion, which contributes to the impaired contractility of cardiomyocytes by inhibiting cellular calcium signalling. We confirmed that lapatinib could be a feasible preventive agent against trastuzumab-induced cardiac complications and provided the rationale for the combined application of lapatinib and trastuzumab in cancer therapy.
Systematic Review with Meta-analysis: The Impact of Cancer Treatments on the Disease Activity of Inflammatory Bowel Diseases
Authors: Grimsdottir Sigrun , Attauabi Mohamed , Kristine Dahl Emilie , Burisch Johan , Seidelin Jakob Benedict 
Published: January 2023

AbstractBackground and AimsThe association between cancer treatments and exacerbation of inflammatory bowel diseases [IBD] is unclear. We aimed to evaluate the effects of cancer treatments on the disease activity of IBD.MethodsWe performed a systematic review of the literature on cancer therapy in patients with pre-existing IBD. Electronic searches of PubMed, Cochrane Library and Embase were combined with manual searches (September 2021). Meta-analysis was performed using the random-effects model. The primary outcome was flares of IBD following cancer therapy. Secondary outcomes were need for IBD-related hospitalization, surgery, and initiation or intensification of steroid or biological treatments to manage IBD flares.ResultsIn total, 33 studies were included in the systematic review, comprising 1298 patients with IBD who received cancer treatment. The overall occurrence of IBD flares following cancer treatment was 30% (95% confidence interval [CI] 23–37%). IBD flares resulted in utilization of systemic steroids and biologic therapies among 25% and 10% of patients, respectively, and in discontinuation of cancer treatment among 14% of patients. Finally, the risk of gastrointestinal toxicity following immune check point inhibitor treatment [ICI] was increased in patients with IBD compared to patients without IBD (RR = 3.62 [95% CI 2.57–5.09]). Despite this, the studies generally reported that flares were manageable.ConclusionsCurrent data indicate a high proportion of patients with IBD experiencing a flare following the start of cancer treatment. Patients with IBD were at an increased risk of gastrointestinal toxicity following ICI treatment compared to those without IBD. However, cancer therapy-induced IBD flares were manageable and should not preclude appropriate cancer treatments.
A Compendium of Mucosal Molecular Characteristics Provides Novel Perspectives on the Treatment of Ulcerative Colitis
Authors: Chang Min-Jing , Hao Jia-Wei , Qiao Jun , Chen Miao-Ran , Wang Qian , Wang Qi , Zhang Sheng-Xiao , Yu Qi , He Pei-Feng 
Published: January 2023

Abstract

Background and Aims
Ulcerative colitis [UC] is a complex heterogeneous disease. This study aims to reveal the underlying molecular features of UC using genome-scale transcriptomes of patients with UC, and to develop and validate a novel stratification scheme.

Methods
A normalised compendium was created using colon tissue samples (455 patients with UC and 147 healthy controls [HCs]), covering genes from 10 microarray datasets. Upregulated differentially expressed genes [DEGs] were subjected to functional network analysis, wherein samples were grouped using unsupervised clustering. Additionally, the robustness of subclustering was further assessed by two RNA sequencing datasets [100 patients with UC and 16 HCs]. Finally, the Xgboost classifier was applied to the independent datasets to evaluate the efficacy of different biologics in patients with UC.

Results
Based on 267 upregulated DEGs of the transcript profiles, UC patients were classified into three subtypes [subtypes A–C] with distinct molecular and cellular signatures. Epithelial activation-related pathways were significantly enriched in subtype A [named epithelial proliferation], whereas subtype C was characterised as the immune activation subtype with prominent immune cells and proinflammatory signatures. Subtype B [named mixed] was modestly activated in all the signalling pathways. Notably, subtype A showed a stronger association with the superior response of biologics such as golimumab, infliximab, vedolizumab, and ustekinumab compared with subtype C.

Conclusions
We conducted a deep stratification of mucosal tissue using the most comprehensive microarray and RNA sequencing data, providing critical insights into pathophysiological features of UC, which could serve as a template for stratified treatment approaches.
Serum lipoprotein(a) and bioprosthetic aortic valve degeneration
Authors: Botezatu Simona B , Tzolos Evangelos , Kaiser Yannick , Cartlidge Timothy R G , Kwiecinski Jacek , Barton Anna K , Yu Xinming , Williams Michelle C , van Beek Edwin J R , White Audrey , Kroon Jeffrey , Slomka Piotr J , Popescu Bogdan A , Newby David E , Stroes Erik S G , Zheng Kang H , Dweck Marc R 
Published: January 2023

Abstract

Aims
Bioprosthetic aortic valve degeneration demonstrates pathological similarities to aortic stenosis. Lipoprotein(a) [Lp(a)] is a well-recognized risk factor for incident aortic stenosis and disease progression. The aim of this study is to investigate whether serum Lp(a) concentrations are associated with bioprosthetic aortic valve degeneration.

Methods and results
In a post hoc analysis of a prospective multimodality imaging study (NCT02304276), serum Lp(a) concentrations, echocardiography, contrast-enhanced computed tomography (CT) angiography, and 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) were assessed in patients with bioprosthetic aortic valves. Patients were also followed up for 2 years with serial echocardiography. Serum Lp(a) concentrations [median 19.9 (8.4–76.4) mg/dL] were available in 97 participants (mean age 75 ± 7 years, 54% men). There were no baseline differences across the tertiles of serum Lp(a) concentrations for disease severity assessed by echocardiography [median peak aortic valve velocity: highest tertile 2.5 (2.3–2.9) m/s vs. lower tertiles 2.7 (2.4–3.0) m/s, P = 0.204], or valve degeneration on CT angiography (highest tertile n = 8 vs. lower tertiles n = 12, P = 0.552) and 18F-NaF PET (median tissue-to-background ratio: highest tertile 1.13 (1.05–1.41) vs. lower tertiles 1.17 (1.06–1.53), P = 0.889]. After 2 years of follow-up, there were no differences in annualized change in bioprosthetic hemodynamic progression [change in peak aortic valve velocity: highest tertile [0.0 (−0.1–0.2) m/s/year vs. lower tertiles 0.1 (0.0–0.2) m/s/year, P = 0.528] or the development of structural valve degeneration.

Conclusion
Serum lipoprotein(a) concentrations do not appear to be a major determinant or mediator of bioprosthetic aortic valve degeneration.