bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation
Authors: Tocantins Carolina , Martins João D. , Rodrigues Óscar M. , Grilo Luís F. , Diniz Mariana S. , Stevanovic‐Silva Jelena , Beleza Jorge , Coxito Pedro , Rizo‐Roca David , Santos‐Alves Estela , Rios Manoel , Carvalho Lina , Moreno António J. , Ascensão António , Magalhães José , Oliveira Paulo J. , Pereira Susana P. 
Published: August 2023

AbstractBackgroundThe consumption of high‐caloric diets strongly contributes to the development of non‐communicable diseases (NCDs), including cardiovascular disease, the leading cause of mortality worldwide. Exercise (along with diet intervention) is one of the primary non‐pharmacological approaches to promote a healthier lifestyle and counteract the rampant prevalence of NCDs. The present study evaluated the effects of exercise cessation after a short period training on the cardiac metabolic and mitochondrial function of female rats.MethodsSeven‐week‐old female Sprague–Dawley rats were fed a control or a high‐fat, high‐sugar (HFHS) diet and, after 7 weeks, the animals were kept on a sedentary lifestyle or submitted to endurance exercise for 3 weeks (6 days per week, 20–60 min/day). The cardiac samples were analysed 8 weeks after exercise cessation.ResultsThe consumption of the HFHS diet triggered impaired glucose tolerance, whereas the HFHS diet and physical exercise resulted in different responses in plasma adiponectin and leptin levels. Cardiac mitochondrial respiration efficiency was decreased by the HFHS diet consumption, which led to reduced ATP and increased NAD(P)H mitochondrial levels, which remained prevented by exercise 8 weeks after cessation. Exercise training‐induced cardiac adaptations in redox balance, namely increased relative expression of Nrf2 and downstream antioxidant enzymes persist after an eight‐week exercise cessation period.ConclusionsEndurance exercise modulated cardiac redox balance and mitochondrial efficiency in female rats fed a HFHS diet. These findings suggest that exercise may elicit cardiac adaptations crucial for its role as a non‐pharmacological intervention for individuals at risk of developing NCDs.
Apheresis collection of mononuclear cells for chimeric‐antigen receptor therapies
Authors: Maitta Robert W. 
Published: August 2023

AbstractCollections of lymphocytes to be genetically modified to treat hematologic malignancies have seen a dramatic increase over the last few years as commercial products have been approved. Reports of new products in development that can possibly treat solid organ malignancies represent a massive change in the field. Apheresis is at the center of the collection of cells for the manufacture of these chimeric‐antigen receptor therapy products. The expansion of these collections represents one of the areas of apheresis procedures growth. This review will summarize concepts important to this type of collection and variables that need to be optimized to obtain desired cell yields while increasing patients' safety.
Undiagnosed major risk factors in acute ischaemic stroke patients: frequency, profile, stroke mechanisms and outcome
Authors: Rêgo André , Nannoni Stefania , Scherz Ali , Eskandari Ashraf , Salerno Alexander , Pereira Miguel , Strambo Davide , Michel Patrik 
Published: August 2023

AbstractBackground and purposeThere is scarce clinical information about the clinical profile of patients with acute ischaemic stroke with previously undiagnosed major vascular risk factors (UMRFs).MethodsThis was a retrospective analysis of data from the Acute Stroke Registry and Analysis of Lausanne registry between 2003 and 2018 with univariate and multivariate logistic regression analyses comparing clinical profiles of patients with UMRFs to patients with at least one previously diagnosed MRF (DMRF).ResultsIn all, 4354 patients (median age 70 years [interquartile range 15.2], 44.7% female) were included after excluding 763 (14.9%) for lack of consent and three for missing information. Amongst 1125 (25.8%) UMRF patients, 69.7% (n = 784) had at least one newly diagnosed MRF and the others none. The newly detected MRFs were dyslipidaemia (61.4%), hypertension (23.7%), atrial fibrillation (10.2%), diabetes mellitus (5.2%), ejection fraction <35% (2.0%) and coronary disease (1.0%). Comparing UMRF patients to DMRF patients, multivariate analysis showed a positive association with lower age, non‐Caucasian ethnicity, contraceptive use (<55 years old), smoking (≥55 years old) and patent‐foramen‐ovale‐related stroke mechanism. A negative association was found with pre‐stroke antiplatelet use and higher body mass index. Functional outcome did not differ. Cerebrovascular recurrences were similar between groups.ConclusionsIn this large single‐centre cohort, 69.7% of patients with acute ischaemic stroke and UMRF were newly diagnosed with at least one new MRF, the most common being dyslipidaemia, hypertension or atrial fibrillation. Patients of the UMRF group were younger, more often smokers and on contraceptives, and had more patent‐foramen‐ovale‐related strokes.
Flight from Liquidity and Corporate Bond Yields
Authors: Nejad Ali Ebrahim , Hoseinzade Saeid , Molanaei Aryan 
Published: August 2023

AbstractThis paper documents that in distress periods, liquidity constrained investors sell liquid corporate bonds and hold onto illiquid ones, a phenomenon which we refer to as flight from liquidity. Performing within issuer‐time analysis to properly control for credit risk, we find that flight from liquidity results in a decline in the liquidity premium. In other words, liquid bonds that are significantly more expensive in normal market conditions, lose more value in distress periods and trade at a closer, and sometimes at an indistinguishable, yield spread to their illiquid peers from the same issuer. We also find that these shocks to the liquidity premium are short‐lived and do not have a long‐lasting pricing impact. We provide suggestive evidence that the liquidity clientele effect derives these results. Our findings suggest that investment exposure to liquid bonds entails a unique risk arising during periods of distress.
Growth form and leaf habit drive contrasting effects of Arctic amplification in long‐lived woody species
Authors: Frigo Davide , Eggertsson Ólafur , Prendin Angela Luisa , Dibona Raffaella , Unterholzner Lucrezia , Carrer Marco 
Published: August 2023

AbstractCurrent global change is inducing heterogeneous warming trends worldwide, with faster rates at higher latitudes in the Northern Hemisphere. Consequently, tundra vegetation is experiencing an increase in growth rate and uneven but expanding distribution. Yet, the drivers of this heterogeneity in woody species responses are still unclear. Here, applying a retrospective approach and focusing on long‐term responses, we aim to get insight into growth trends and climate sensitivity of long‐lived woody species belonging to different functional types with contrasting growth forms and leaf habits (shrub vs. tree and deciduous vs. evergreen). A total of 530 samples from 7 species (common juniper, dwarf birch, woolly willow, Norway spruce, lodgepole pine, rowan, and downy birch) were collected in 10 sites across Iceland. We modelled growth trends and contrasted yearly ring‐width measurements, filtering in high‐ and low‐frequency components, with precipitation, land‐ and sea‐surface temperature records (1967–2018). Shrubs and trees showed divergent growth trends, with shrubs closely tracking the recent warming, whereas trees, especially broadleaved, showed strong fluctuations but no long‐term growth trends. Secondary growth, particularly the high‐frequency component, was positively correlated with summer temperatures for most of the species. On the contrary, growth responses to sea surface temperature, especially in the low frequency, were highly diverging between growth forms, with a strong positive association for shrubs and a negative for trees. Within comparable vegetation assemblage, long‐lived woody species could show contrasting responses to similar climatic conditions. Given the predominant role of oceanic masses in shaping climate patterns in the Arctic and Low Arctic, further investigations are needed to deepen the knowledge on the complex interplay between coastal tundra ecosystems and land‐sea surface temperature dynamics.
A Critical Reading of Jean‐Luc Marion's Interpretation of Anselm's Ontological Argument
Authors: Kim Young Won 
Published: August 2023

AbstractIn this essay, I qualify Jean‐Luc Marion's anti‐ontological interpretation of Anselm's argument. Marion claims that the argument is not ontological but in line with Dionysian apophatic theology. To substantiate his anti‐ontological reading, Marion suggests that the main regulative idea of the Proslogion is bonum. The final regulative idea, however, is gaudium, since gaudium, not bonum, leads the argument to the beatific vision. If we reformulate the Proslogion focusing on gaudium, we find that Marion's analysis misses the evident ontological aspects of the argument, such as the tradition of prayer and hermeneutics. Since Anselm promulgated the argument within the Benedictine tradition of Bec, the practice of prayer or meditation is the legitimate context of the argument. However, because of his emphasis on the structure of call and response over the ontological and hermeneutical aspects of revelation, his analysis neglects the importance of the hermeneutic relation within which the Proslogion is born.
Longitudinal associations between diet quality, sedentary behaviours and physical activity and risk of overweight and obesity in preschool children: The ToyBox‐study
Authors: Miguel‐Berges María L. , Mouratidou Theodora , Santaliestra‐Pasias Alba , Androutsos Odysseas , Iotova Violeta , Galcheva Sonya , De Craemer Marieke , Cardon Greet , Koletzko Berthold , Kulaga Zbigniew , Manios Yannis , Moreno Luis A. ,   the ToyBox‐study group
Published: August 2023

SummaryBackgroundLifestyle behaviours related to diet and physical activity are associated with increased risk of obesity and evidence suggests that associations might be stronger when a synergetic effect is examined.ObjectiveTo examine the cross‐sectional and longitudinal associations between diet, screen time (ST) and step recommendations and risk of overweight and obesity in European preschoolers participating in the ToyBox‐study.MethodsIn this cluster‐randomized clinical trial, 718 children (51.4% boys) from six European countries participated. Parents filled out questionnaires with information on socio‐demographic status, step recommendations and ST.ResultsLongitudinal results indicate that participants having a low Diet Quality Index (DQI), not meeting ST and step recommendations at T0 and T1 had higher odds of having overweight/obesity at T1 (odds ratio [OR] = 1.116; 95% confidence interval [CI] = 1.104–2.562) than those children having a high DQI and meeting ST and step recommendations at T0 and T1. Similarly, participants having a high DQI, but not meeting ST and step recommendations at T0 and T1 had increased odds of having overweight/obesity (OR = 2.515; 95% CI = 1.171–3.021).ConclusionsThe proportion of participants having a low DQI, not adhering to both step and ST recommendations was very high, and it was associated with a higher probability of having overweight and obesity.
Structural evolution and oxidation resistance of polysilazane‐derived SiCN–HfO2 ceramics
Authors: Anand Rahul , Lu Kathy , Nayak Bibhuti B. , Behera Shantanu K. 
Published: August 2023

AbstractPolymer‐derived SiCN materials have great application potential in high‐temperature environments. In the current work, SiCN ceramics were tailored with Hf incorporation through doping of a molecular precursor in the preceramic polymer. The ceramics remained in a single amorphous phase up to 900°C. Further annealing caused nucleation and crystallization of tetragonal hafnium oxide (t‐HfO2) within the SiCN matrix, resulting in a unique glass–ceramic nanocomposite of t‐HfO2–SiCN. The crystal sizes of t‐HfO2 were in the range of 2.3–5.1 nm. Raman spectroscopy was employed to examine the effect of Hf‐doping on the phase separation and crystallization of sp2‐carbon. Thermal stability in an oxidizing environment was analyzed by thermogravimetry. The incorporation of Hf in the SiCN ceramic system led to improved phase stability and oxidation resistance compared to the undoped SiCN system.
Do creditor control rights impact corporate tax aggressiveness? Evidence from debt covenant violations
Authors: Cheng C. S. Agnes , Francis Bill B. , Li Zhi , Shen Yinjie , Wu Qiang 
Published: August 2023

AbstractWe examine the effect of bank interventions on corporate tax aggressiveness via the lens of debt covenant violations. Using three identification strategies, we find that bank interventions have a negative effect on corporate tax aggressiveness. This effect is less pronounced for more financially constrained firms, firms with higher shareholder power and firms facing less powerful banks. Covenant‐violating firms compensate their reduced tax aggressiveness by reducing other expenditures, including capital expenditures and cash acquisitions. Our results suggest that creditors perceive aggressive tax activities as risky investment opportunities.
Fast–slow atrioventricular nodal re‐entrant tachycardia incorporating superior and inferolateral left atrial slow pathways
Authors: Matsumoto Kazuhisa , Mori Hitoshi , Nagashima Koichi , Kaneko Yoshiaki , Kato Ritsushi 
Published: August 2023

AbstractBackgroundA 70‐year‐old man revealed a rare type of atrioventricular nodal re‐entrant tachycardia (AVNRT) involving distinct retrograde pathways, superior slow pathway, and inferolateral left atrial slow pathway.ResultRadiofrequency ablation was successfully performed on the noncoronary cusp and in the left atrium, respectively, to eliminate the tachycardias.Discussion and ConclusionDue to the anomalous electrical conduction patterns, careful diagnosis and ablation strategies were necessary to avoid the risk of atrioventricular block. These findings underscore the diversity and complexity of AVNRT and highlight the importance of tailored therapeutic approaches.
Phosphorylated MAPK11 promotes the progression of clear cell renal cell carcinoma by maintaining RUNX2 protein abundance
Authors: Song Xiandong , Dong Changming , Man Xiaojun 
Published: August 2023

AbstractPrevious studies have demonstrated that mitogen‐activated protein kinase 11 (MAPK11) functions as an important point of integration in signalling transduction pathways and controlling endocellular processes, including viability of cells, differentiation, proliferation and apoptosis, through the sequence phosphorylation of the substrate protein Ser/Thr kinase protein cascade. Though MAPK 11 plays an important role in various tumours, especially in the invasive and metastatic processes, its expression and molecular mechanism in clear cell renal cell carcinoma (ccRCC) remain unclear. Runt‐associated transcription factor 2 (RUNX2), a main transcription factor for osteoblast differentiation and chondrocyte maturation, has high expression in a number of tumours. In this study, the mRNA and protein levels of targeted genes in ccRCC tissues and adjacent tissues are analysed using the Cancer Genome Atlas (TCGA) database and western blotting. The ccRCC cell proliferation was measured with colony formation and EdU assay, and cell migration was examined through transwell assay. The interactive behaviour between proteins was detected with immunoprecipitation. Half‐life period of RUNX2 protein was measured with cycloheximide chase assay. The results of the study indicated overexpression of MAPK11 and RUNX2 in ccRCC tissues and cell lines. MAPK11 and RUNX2 promoted the ccRCC cell proliferation and migration. Additionally, physical interaction took place between RUNX2 and P‐MAPK11, which functioned to sustain the stability of RUNX2 protein. The high expression of RUNX2 could neutralize the functional degradation in MAPK11. And the outcomes of the study suggest that the P‐MAPK11/RUNX2 axis may be used as a potential therapeutic target of ccRCC.
DCAMCP: A deep learning model based on capsule network and attention mechanism for molecular carcinogenicity prediction
Authors: Chen Zhe , Zhang Li , Sun Jianqiang , Meng Rui , Yin Shuaidong , Zhao Qi 
Published: August 2023

AbstractThe carcinogenicity of drugs can have a serious impact on human health, so carcinogenicity testing of new compounds is very necessary before being put on the market. Currently, many methods have been used to predict the carcinogenicity of compounds. However, most methods have limited predictive power and there is still much room for improvement. In this study, we construct a deep learning model based on capsule network and attention mechanism named DCAMCP to discriminate between carcinogenic and non‐carcinogenic compounds. We train the DCAMCP on a dataset containing 1564 different compounds through their molecular fingerprints and molecular graph features. The trained model is validated by fivefold cross‐validation and external validation. DCAMCP achieves an average accuracy (ACC) of 0.718 ± 0.009, sensitivity (SE) of 0.721 ± 0.006, specificity (SP) of 0.715 ± 0.014 and area under the receiver‐operating characteristic curve (AUC) of 0.793 ± 0.012. Meanwhile, comparable results can be achieved on an external validation dataset containing 100 compounds, with an ACC of 0.750, SE of 0.778, SP of 0.727 and AUC of 0.811, which demonstrate the reliability of DCAMCP. The results indicate that our model has made progress in cancer risk assessment and could be used as an efficient tool in drug design.
Chromosome instability region analysis and identification of the driver genes of the epithelial ovarian cancer cell lines A2780 and SKOV3
Authors: Li Jianxiong , Chen Zexin , Xiao Wentao , Liang Huaguo , Liu Yanan , Hao Wenqi , Zhang Yongli , Wei Fengxiang 
Published: August 2023

AbstractEpithelial ovarian cancer (EOC) is one of the most prevalent gynaecological cancers worldwide. The molecular mechanisms of serous ovarian cancer (SOC) remain unclear and not well understood. SOC cases are primarily diagnosed at the late stage, resulting in a poor prognosis. Advances in molecular biology techniques allow us to obtain a better understanding of precise molecular mechanisms and to identify the chromosome instability region and key driver genes in the carcinogenesis and progression of SOC. Whole‐exome sequencing was performed on the normal ovarian cell line IOSE80 and the EOC cell lines SKOV3 and A2780. The single‐nucleotide variation burden, distribution, frequency and signature followed the known ovarian mutation profiles, without chromosomal bias. Recurrently mutated ovarian cancer driver genes, including LRP1B, KMT2A, ARID1A, KMT2C and ATRX were also found in two cell lines. The genome distribution of copy number alterations was found by copy number variation (CNV) analysis, including amplification of 17q12 and 4p16.1 and deletion of 10q23.33. The CNVs of MED1, GRB7 and MIEN1 located at 17q12 were found to be correlated with the overall survival of SOC patients (MED1: p = 0.028, GRB7: p = 0.0048, MIEN1: p = 0.0051), and the expression of the three driver genes in the ovarian cell line IOSE80 and EOC cell lines SKOV3 and A2780 was confirmed by western blot and cell immunohistochemistry.
A retrospective analysis of the factors associated with surgical checklist compliance using data from a local health unit in Italy, 2018–2021
Authors: Rossi Nicole , Golinelli Luca , Bersani Federica , Geraci Marco 
Published: August 2023

AbstractRationaleSince its publication, the World Health Organization Surgical Safety Checklist (SSC) has been progressively adopted by healthcare providers around the world to monitor and safeguard the delivery of surgeries. In one Italian region's health system, the SSC and other two surgery‐specific checklists were supplemented by a document that records any non‐conformity (NC) arising from the safety checks.Aims and ObjectivesIn this study, we investigated the factors associated with NCs using data from a local health unit (LHU). The secondary aim of this study was to explore the potential impact of the coronavirus crisis on surgical checklist compliance.MethodsWe used data on surgical activity from the Modena LHU between 2018 and 2021 and the accompanying NC documents. The primary goal was to estimate the relative risk (RR) of NCs according to several factors, including checklist incompleteness and surgery class (elective, urgent or emergency), using Poisson regression. A similar analysis was performed separately for 2018–2019 and 2020–2021 to assess the COVID‐19 potential impact.Results and ConclusionsChecklist compliance in the LHU was 95%, with the presence of NCs in about 7% of surgeries. The factors that increased the RR were incompleteness of the checklist (adjusted RR = 3.12; 95% confidence interval [CI] = 2.86–3.40), urgent surgeries (adjusted RR [aRR] = 1.59; 95% CI = 1.47–1.72), emergencies (aRR = 2.09; 95% CI = 1.15–3.79), and surgeries with more than four procedures (aRR = 1.64; 95% CI = 1.41–1.92). Most notably, the RR for incomplete checklists showed a negative association with NCs before the COVID‐19 outbreak but positive afterwards. Checklist compliance was overall satisfactory, though the observation of noncompliant checklists of about 1000 per year suggests there is still room for improvement. Moreover, attention to the checklist best practices and organization of outpatient workload may have been affected by the exceptional circumstances of the pandemic.
Wear of lithium disilicate opposed by various ceramic materials
Authors: Shah Krisha , Lawson Nathaniel C. , Sayed Ahmed Akram , Nizami Bushra , Lawson Thomas J. , Kee Edwin , Nejat Amir H. 
Published: August 2023

AbstractObjectivesTo compare volumetric wear of lithium disilicate against different ceramic (3 mol% yttria‐stabilized (3Y) zirconia, 5 mol% yttria‐stabilized (5Y) zirconia, lithium disilicate, porcelain and enamel antagonists).Materials and MethodsForty lithium disilicate (e.max CAD) specimens (n = 8/antagonist) were wet sanded to 1200grit SiC and mounted into a UAB wear device. Antagonist spheres (diameter = 4.75 mm) were made from polished 3Y zirconia, 5Y zirconia, lithium disilicate, porcelain and human enamel. A two‐body wear test was performed with 20 N load and 1.5 mm slide for 400,000 cycles at 1 Hz. 33% glycerin was used as a lubricant. Wear facets were measured with optical profilometry. Wear scar areas of antagonists were measured with digital microscopy. Scanning electron microscopy was performed on wear facets and scars. Vicker's microhardness was measured of all antagonist materials. All data were compared with 1‐way ANOVA and Tukey post‐hoc analysis.ResultsSignificant differences in lithium disilicate volumetric wear (mm3) occurred with various antagonist materials: 0.38 ± 0.01a (3Y zirconia), 0.33 ± 0.01b, (5Y zirconia), 0.16 ± 0.01c (lithium disilicate), 0.11 ± 0.03d, (enamel), and 0.07 ± 0.01e (porcelain). The lithium disilicate antagonist demonstrated a larger wear scar than other materials. Zirconia was the hardest material and enamel the least hard.ConclusionsZirconia causes significant wear on lithium disilicate and lithium disilicate causes significant wear against itself.Clinical SignificanceWhen selecting a material to oppose an existing lithium disilicate crown, a porcelain or lithium disilicate surface would cause significantly less wear to the existing crown. If an existing zirconia crown exists opposed to a prepared tooth, lithium disilicate may not be an ideal material selection to restore the tooth.