bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of chronic hepatitis B: options, monitoring, special cases and adverse effects
Authors: Litwin Mateusz , Mikosińska Agnieszka , Parys Jakub , Kałuziak Patrycja , Witek Aleksandra , Kaźmierczak Martyna , Jesionek Stanisław , Jajczak Marta , Mossakowski Maciej 
Published: January 2025

Introduction:
Hepatitis B remains a significant clinical issue. Despite the availability of effective vaccines, the world is still not free from this problem. Chronic hepatitis B virus (HBV) infection affects approximately 296 million people worldwide and is the leading cause of cirrhosis and liver cancer globally. HBV-related cirrhosis resulted in an estimated 331,000 deaths in 2019, and it is estimated that the number of deaths from HBV-related liver cancer in 2019 was 192,000, an increase from 156,000 in 2010. The rate of vaccination is particularly unsatisfactory in low-income countries, but even in high-income countries, the issue of hepatitis B has not been completely eradicated.
Aim of the study: The aim of this paper is primarily to systematize knowledge regarding the natural course of HBV infection and therapeutic options for chronic hepatitis B, both in adults and children. It also aims to highlight the principles of monitoring pharmacotherapy. The paper also describes therapeutic possibilities in special cases, such as pregnancy, liver transplantation, and the initiation of immunosuppressive therapy. Attention is also given to the potential adverse effects of pharmacotherapy.
Conclusions:
As hepatitis B infection continues to pose a significant global health challenge and remains the leading cause of liver cirrhosis and hepatocellular carcinoma, it is essential to review the available treatment options for this condition. Even in Europe, where vaccination coverage has reached high levels, cases of hepatitis B are still detected, often incidentally. This review aims to provide an in-depth analysis of therapeutic approaches for chronic hepatitis B, considering factors such as patient age, clinical status, and liver fibrosis stage. Additionally, it emphasizes the importance of monitoring treatment efficacy and safety, while also addressing the potential adverse effects associated with antiviral therapy.
Os Significados da Experiência Hiperfágica na Compulsão Alimentar e na Bulimia Nervosa
Authors: Bloc Lucas Guimarães , De Souza Brenda Nogueira Caracas , Moreira Virginia 
Published: January 2025

Os transtornos alimentares costumam ser caracterizados por perturbações na forma e na configuração do ato de comer, resultando em um modo alterado de consumir alimentos, como no caso da hiperfagia. Ela revela a experiência de um sujeito que não consegue não comer que está presente na compulsão alimentar e na bulimia nervosa. Esta pesquisa busca compreender os significados da experiência hiperfágica na compulsão alimentar e na bulimia nervosa. Utilizando o método fenomenológico crítico de pesquisa, inspirado na fenomenologia de Merleau-Ponty, realizamos oito entrevistas com pacientes de um serviço interdisciplinar para transtornos alimentares. Utilizamos a seguinte pergunta disparadora: "Como é pra você comer?". Como resultados, os sentidos antagônicos do comer, a culpa, o descontrole, a compensação, a relação com o corpo e o olhar do outro foram experiências descritas nos dois diagnósticos e que foram discutidos sob uma lente fenomenológica. Concluímos que há uma dimensão comum da experiência hiperfágica na compulsão alimentar e na bulimia nervosa que se relaciona a uma alteração do modo de experienciar o próprio corpo e o impacto do olhar do outro na construção da própria identidade, o que converge de forma direta com as pesquisas de cunho fenomenológico que vêm sendo realizadas.
TOMMY HILFIGER E COLARES PIRAHÃ:
Authors: Delamar Roque Eliane , Luiz Cunha Cardoso Filho Jorge 
Published: January 2025

Este trabalho, se refere a uma análise sobre a vida dos objetos e sua forma de circulação nos espaços, tomando como ponto de partida o registro fotográfico de Taiçapa, líder indígena Amazonense, feito na aldeia de seu povo: os Pirahãs. A imagem é analisada a partir de dois elementos da indumentária de Taiçapa: a camisa pólo da marca Tommy Hilfiger e o colar Pirahã. Para a análise, trazemos os estudos de Milton Santos e Walter Benjamin, respectivamente, sobre sistema de objetos e aura; e de Kopytoff e Appadurai, sobre Antropologia das coisas. Busca-se propor uma reflexão acerca da existência de dois universos comparáveis pelos quais transita a mercadoria: o singular e o comum. E descrever como as conexões materiais agenciam os contatos entre diferentes culturas. Por fim, nas considerações finais, fica estabelecido que o diálogo entre culturas é perceptível pela atuação destes objetos nas relações de contato, como atores que discursam sobre sua origem geográfica e sociocultural, mas também são capazes de transcender esta origem, quando seu valor está agenciado pela totalidade de crenças que traz para dentro do processo subjetividades que engendram e criam valores.
Compact temperature-insensitive high-energy VCSEL side-pumped Nd:YAG laser with a VRM output coupler
Authors: Li Jing-Yu , Yang Jing , Wang Hao , Li Xue-Peng , Guo Ya-Ding , Gao Hong-Wei , Han Lin , Wang Xiao-Jun 
Published: January 2025

A compact temperature-insensitive high-energy Q-switch Nd:YAG laser is demonstrated based on vertical cavity surface emitted laser (VCSEL) side-pumping and a variable reflectivity mirror (VRM) output coupler (OC). With the optimization of the laser parameters, the laser delivers an output energy of 217 mJ operating at pulse repetition rate of 100 Hz with 7 ns pulse width and a peak power of 31 MW. The brightness is estimated to be 10.34×106MW/mm2/sr. The spatial beam exhibits a near-flat-top intensity distribution with good beam quality of M2∼2.3. The temperature stability is measured at full output energy, indicating an energy variation within 1.8% for the temperature range from 15°C to 35°C.
Esophageal Adenocarcinoma Presenting With Hypercalcemia
Authors: Patel Rayna , Chinnam Sahithi , Karrick Megan , Kobeissy Abdallah 
Published: January 2025

ABSTRACT
Hypercalcemia is an identified complication of several malignancies and can cause significant adverse events. It is usually associated with cancers of the breast, lung (especially squamous cell), renal cell carcinoma, and multiple myeloma. Here, we present a rare case of esophageal adenocarcinoma presenting with hypercalcemia.
A Socio-Historical Mapping of Translation Fields: A Case Study of English Self-Help Literature in Arabic Translation
Authors: Alqarni Abdullah , Altalidi Bandar , Sahari Yousef 
Published: January 2025

Abstract
This study advances the application of Pierre Bourdieu’s social field as a heuristic conceptual tool in the context of translation studies, offering a methodological framework that integrates socio-historical analysis with bibliographical research. By exploring the field of Arabic translations of English self-help literature in the Kingdom of Saudi Arabia (KSA) between 1982 and 2016, the article illustrates how Bourdieu’s conceptualisation of social fields can be operationalised to define the boundaries, agents, production, and practices within a translation field. A bespoke bibliographical database comprising 993 translated self-help titles was constructed to provide a detailed mapping of the field’s historical trajectory and production dynamics. Through this integration of theory and empirical data, the study demonstrates how field theory can enrich the analysis of translation as a social practice, revealing the interactions between translation agents and the socio-historical forces that shape the production of translations. The findings suggest that this integrated approach can serve as a heuristic model for the socio-historical analysis of translation fields across different language pairs, temporal periods, and geographic contexts, contributing to future research in translation sociology and translation bibliographies.
Restitution of Jewish Property in Northern Transylvania During the Early Postwar Years
Authors: Ionescu Stefan Cristian 
Published: January 2025

Abstract
The restitution of Jewish property in the multiethnic region of Northern Transylvania faced numerous challenges during the first post-Holocaust years as a result of the complicated wartime history, postwar demographics, legal status, interethnic dynamics, and occasional violence. Having the lowest rate of survival among all Jewish communities in Romania, most of the region’s Jews died during the deportation and did not return to their native places to claim their properties. This impacted the extent of restitution of individual private property. Some of the Aryanized property was restituted to the Jewish survivors or their heirs because the wartime beneficiaries fled the country or renounced posession since they were afraid of potential negative consequences. Part of the restitution took place through court litigation and this gives researchers a chance to assess the extent of Jewish success in obtaining restitution. The Supreme Court decisions in restitution cases show that the Jewish plaintiffs were completely successful in their litigation based on law 645/1945 that cancelled the transactions with property Aryanized during the Hungarian rule of Northern Transylvania. This was a much higher success rate, compared to the general share of success for Jewish litigation at the entire country level – around 66 %.
A micro-anatomical investigation of dark and light-adapted eyes of Chilades pandava (Lepidoptera: Lycaenidae)
Authors: Ling Jing , Chen Hong-Ye , Xu Tian , Huang Yi-Ting , Huang Da-Ming , Zheng Xia-Lin 
Published: January 2025

Abstract

Chilades pandava (Horsfield) (Lepidoptera: Lycaenidae) is a notorious defoliating pest of Cycas spp. (Cycadaceae) in the tropical and subtropical regions of the world. The primary visual receptors of butterflies are the compound eyes. To understand the perception of visual stimuli in Ch. pandava, the external morphology and internal microstructure of Ch. pandava compound eyes were examined using light and scanning electron microscopy. The number of ommatidia was approximately equal in both sexes, and the eyes of Ch. pandava are of the apposition type, with the crystalline cone directly connected to the rhabdom. Significant differences were observed in the length of the crystalline cone and the width of retinula cell nucleus and crystalline cone under light-adapted conditions compared to those under dark-adapted conditions. Under light-adapted conditions, pigment granules moved to and remained below the crystalline cone and were near the rhabdom. In contrast, under dark-adapted conditions, pigment granules moved to the distal end of ommatidia, near the cornea, and exhibited a more spatially distributed pattern. These results provide essential information for exploring the poorly understood sensory ecology of butterflies in the family Lycaenidae.
Removing fluorine and chlorine from zinc oxide dust by wet alkaline washing and studying fluorine occurrence states
Authors: Wang Xixi , Li Jiahui , Sun Pu , Deng Zhigan , Li Xingbin , Li Mingting , Wei Chang 
Published: January 2025

Abstract
When zinc hydrometallurgy is used to treat zinc oxide dust (ZOD), the fluorine (F) and chlorine (Cl) in the dust interfere with zinc electrowinning. To investigate the effectiveness of F and Cl removal from ZOD by different alkaline washing methods. Under the condition that 16 g/L Na2CO3 was mixed with 6 g/L NaOH in equal volume 1:1 and reacted with the dust under the optimum condition of the liquid-solid ratio of 5 mL/g for 2 h at 70 °C, final pH of 10, and stirring intensity of 400 rpm, the dechlorination of cloth bag zinc oxide dust (CBZOD) and boiler zinc oxide dust (BZOD) were 94.81 % and 90.63 %, respectively, and the defluorination were 84.81 % and 24.50 %, respectively. To further reveal the reasons for the difficult removal of F from ZOD, a step extraction method and physical phase analysis of residue were used, which resulted in more than 98 % removable fluoride in CBZOD and up to 56 % insoluble residue in BZOD. Therefore, it is obvious that the removal effect is better due to the presence of large amounts of removable fluoride and chloride in CBZOD; the F states and percentage of insoluble fluoride are main reasons affecting the removal of F.
The Influence of Aging on Hip Abductor Muscle Torque, Power, Velocity and the Association With Lower Limb Physical Function
Authors: Lanza Marcel Bahia , de Souza Carolina da Cruz , Gray Vicki L. 
Published: January 2025

Background and Purpose:
Muscle strength, power, and mass decline with aging, leading to functional loss highly correlated with balance and falls in older adults. Lower limb muscle function is critical for fall prevention in older adults, and hip abductor force and rapid force development have been shown to be important during stepping tasks. However, it remains unclear whether hip abductor muscle function changes with aging. Therefore, the primary aim of this study was to compare maximum torque, submaximal power, and submaximal velocity of hip abductor muscles, as well as hip abductor strength and power clinical assessments, between young and older adults. The secondary aim was to investigate whether there is a relationship between the clinical assessments and hip abduction maximum torque, submaximal power, and submaximal velocity in young and older adults.

Methods:
The volunteers young (n = 20, 26.5 ± 3.9) and older (n = 20, 71.9 ± 5.3) adults performed a hip abduction estimated 1-repetition maximum (e1RM) and submaximal tests (40%, 60%, and 70% of e1RM) and clinical assessments (stair climb power test and the 30-second chair stand test).

Results:
Older adults exhibited a statistically significant decline in hip abduction torque, power, and velocity, accompanied by lower scores in clinical assessments in comparison to young adults. However, young adults did not exhibit any significant associations between clinical assessments and hip abduction maximum torque, power, and velocity, whereas older adults demonstrated strong correlations (r ≥ 0.52, P ≤ .02).

Discussion:
Older adults have a significant reduction in their ability to produce hip abduction torque, power, and velocity, as well as poor performance in clinical assessments compared to young adults. The declines in hip abductor maximum torque, power, and velocity with aging may be related to functional performance, as shown by the significant correlations between these variables and clinical assessments in older adults.

Conclusion:
Health care professionals should consider declines in the ability to generate muscle force rapidly, given its significance to lower limb function and overall physical capabilities.
Sarah E. Duffy & Michele I. Feist. Time, Metaphor, and Language. A Cognitive Science Perspective. Cambridge: Cambridge University Press, 2023, pp. 190
Authors: Šeškauskienė Inesa 
Published: January 2025

Sarah E. Duffy & Michele I. Feist. Time, Metaphor, and Language. A Cognitive Science Perspective. Cambridge: Cambridge University Press, 2023, pp. 190, ISBN 978-1-107-19403-8, DOI: https//doi.org/10.1017/9781108150101
Método investigativo-creativo aplicado al diseño de interior residencial generado mediante contenedores marítimos
Authors: Reinoso Yunga Edwin Nestorio , Zhindón Duarte Jonnathan Andrés 
Published: January 2025

En la actualidad el método investigativo-creativo ha tomado un papel de gran importancia en el campo del diseño y la arquitectura, el cual es reflejo de una sociedad racionalista enfocada o inspirada en el pensamiento crítico producto de una larga evolución de métodos y técnicas aplicados para resolver determinado problema. Las metodologías han significado un cambio radical al momento de proyectar debido no solo a su aporte de recopilación e interpretación de datos, sino también por el fuerte soporte teórico y descriptivo que aporta a diferentes investigaciones en la rama del diseño y la arquitectura. En el presente documento científico se muestran los resultados del uso de las metodologías de investigación aplicados al caso de estudio Propuesta de diseño residencial mediante containers en la ciudad de Cuenca-Ecuador, para la familia Arévalo (2019). De esta manera, el análisis permite entender a profundidad cómo el proceso de cada uno de los métodos utilizados posibilita al investigador profundizar su conocimiento en cada tema y dicho conocimiento genera un vínculo y es un punto de progreso y de retroalimentación para el desarrollo de nuevas ideas o incógnitas y así obtener un óptimo resultado.
La actividad coral, como manifestación artística y social en Guayaquil: necesidad de su expansión
Authors: Mora Cobo Alex Fernando , Vargas Prías Gustavo Daniel 
Published: January 2025

El canto coral no solo contribuye a la formación de un músico, es necesario destacar la contribución de esta expresión artística al “desarrollo social, afectivo, emocional, del ser humano y a la académica en esta área, para el beneficio de la sociedad en general.
Neural Networks for Statistical Modeling: Achieving Highly Accurate Chemical Oxygen Demand Prediction in Herbicide-Contaminated Wastewater
Authors: EL HAMZAOUI YOUNESS , Campos Beatriz Fernanda Tejero , Arellano Juan A Álvarez , Arcos Leonardo Palemón , Cruz Homero Toral 
Published: January 2025

Herbicide-contaminated wastewater poses a critical environmental challenge, largely due to the difficulty of accurately predicting Chemical Oxygen Demand (COD) removal efficiency. This study introduces a systematic Artificial Neural Network (ANN) approach to model COD dynamics during the advanced oxidation (sonophotocatalytic) degradation of two commercial herbicides (Alazine and Gesaprim). Multiple backpropagation algorithms—including Gradient Descent, Conjugate Gradient, Quasi-Newton, and Levenberg-Marquardt—were evaluated to identify the most effective training strategy for COD prediction.
The optimal ANN architecture (6-10-1) consisted of six input neurons, ten hidden neurons, and one output neuron, using a hyperbolic tangent sigmoid transfer function in the hidden layer and a linear transfer function in the output layer. Trained on a dataset of 500 samples (70% for training; 30% for validation), this model achieved near-perfect correlation between measured and predicted COD values (R² = 0.9999, RMSE = 0.0140).
Key findings include:
•	Parameter Characterization: Six operational variables (reaction time, pH, TiO₂ concentration, UV intensity, ultrasound frequency, and herbicide concentration) were assessed for their impact on COD removal.
•	Dominant Variables: Reaction time emerged as the most influential parameter (59.91%), followed by herbicide concentration (8.3%) and TiO₂ concentration (7.5%).
•	Algorithm Performance: Levenberg-Marquardt provided superior predictive performance (p &lt; 0.01) among the tested backpropagation algorithms.
•	Robust Validation: Friedman tests confirmed the reliability of the ANN models for COD prediction.

Uniqueness of the Present Work
While prior studies have underscored the growing importance of ANNs in wastewater treatment and herbicide degradation, none directly match the objectives and depth of this research. Beyond comparing multiple backpropagation algorithms and integrating sensitivity analysis, a novel “Neural Networks for Statistical Modeling” methodology was developed, complete with a comprehensive Graphical User Interface (GUI) and advanced statistical tests. This unique combination of algorithmic evaluation, in-depth statistical analysis, and user-friendly implementation offers new perspectives on optimizing herbicide degradation processes, with potential to reduce operational costs and environmental risks in agricultural and industrial applications.
Future studies will focus on practical implementation strategies and scaling up to full-scale operations, further solidifying the model’s efficacy for real-time monitoring and process optimization in advanced oxidation processes.
DNA methylation is associated with oxidative stress and genomic deregulation in diabetes mellitus
Authors: Sen Subhrojit 
Published: January 2025

Abstract

Aims:
Retrotransposons may undergo aberrant methylation leading to genomic deregulation in diabetes mellitus. The present study evaluated the methylation of retrotransposons namely Alu, B1, and LINE-1 elements in glucose-induced endothelial cells (ECs) and T1DM. The correlation between methylation of these retrotransposons and oxidative stress was investigated. Additionally, methylation of FN1, VEGFa, and EDN1 genes was analyzed.
Methods:
Hot start PCR of the bisulfite converted DNA isolated from the ECs and kidneys for the methylation of retrotransposons was analyzed. Quantification of methylated DNA in ECs was performed by ELISA. The methylation of the FN1, VEGFa, and EDN1 genes was examined. Oxidative stress was evaluated by measuring the superoxide anion, mitochondrial reactive oxygen species (ROS), 8-Hydroxyguanosine (8-OHdG), and NF-kappaB p(65).
Results:
Hypermethylation of Alu and LINE-1 elements occurred in the high glucose- induced ECs. B1 hypermethylation was observed in the kidneys of T1DM mice. Hyperglycemia resulted in LINE-1 hypermethylation in the kidneys of T1DM mice. Hypermethylation of the FN1, VEGFa and EDN1 genes occurred in the high glucose-induced ECs and diabetic kidneys. Hypermethylation of the retrotransposons, oxidative stress and NF-kappaB p(65) were inhibited by 5-Aza-Dc and ginseng treatment.
Conclusions:
This study illustrated that retrotransposon hypermethylation and oxidative stress were evident in the glucose-induced ECs and T1DM along with hypermethylation of the FN1, VEGFa and EDN1 genes. The study also demonstrated the association between hypermethylation of these retrotransposons and oxidative stress in diabetes.
Intein-mediated split SaCas9 for genome editing in plants
Authors: Hu Danling , Hu Lizhe , Lu Yaqiang , Dong Xiao , Cao Xingyu , Bai Shasha , Zhang Lingang , Li Dongming , Sun Yongwei 
Published: January 2025

Abstract

Virus-induced genome editing (VIGE) technologies have been developed to address the limitations of plant genome editing, which heavily relies on genetic transformation and regeneration. However, the application of VIGE in plants is hampered by the challenge posed by the size of the commonly used gene-editing nucleases, Cas9 and Cas12a. To address this challenge, our study explores the potential application of inteins in VIGE, internal protein elements known for mediating post-translational protein splicing by self-excising from precursor proteins and ligating adjacent protein sequences. We demonstrate that an intein-mediated split SaCas9 system not only functions effectively in plant genome editing but also achieves efficiency comparable to that of the wild-type SaCas9. Importantly, we have successfully implemented VIGE using this intein-mediated split SaCas9 system in sheepgrass, a Gramineae forage that is notoriously difficult to genetically transform.