bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐Equilibrium Bose–Einstein Condensation of Exciton‐Polaritons in Silicon Metasurfaces
Authors: Castellanos Gabriel W. , Ramezani Mohammad , Murai Shunsuke , Gómez Rivas Jaime 
Published: January 2023

AbstractExciton‐polaritons (EPs) are hybrid light–matter quasi‐particles with bosonic character formed by the strong coupling between excitons in matter and photons in optical cavities. Their hybrid character offers promising prospects for the realization of non‐equilibrium Bose–Einstein condensates (BECs), and room‐temperature BECs are possible with organic materials. However, the thresholds required to create BECs of organic EPs remain still high to allow condensation with electrical injection of carriers. One of the factors behind these high thresholds is the very short cavity lifetimes, leading to a fast EP decay and the need to inject higher exciton densities in the reservoir to form the condensate. Here a BEC of EPs in organic dyes and all‐dielectric metasurfaces at room temperature is demonstrated. By using dielectric metasurfaces that exhibit very low losses it is possible to achieve cavity lifetimes long enough to allow an efficient population of EP states via vibrational relaxation and radiative pumping. It is shown how polariton lasing or non‐equilibrium Bose–Einstein condensation is achieved in several cavities, and one of the lowest reported thresholds for BECs in organic materials is observed.
Ultrasensitive Detection and Cellular Photothermal Therapy via a Self‐Photothermal Modulation Biosensor
Authors: Xiao Aoxiang , Zheng Jiaying , Wu Xiaolan , Cui Wei , Chen Pengwei , Liang Jiaxuan , Zhong Junyang , Huang Yugang , Huang Yunyun , Guan Bai‐Ou 
Published: January 2023

AbstractThe use of light, which is s a powerful tool for imaging and sensing, has also become one of the most prospective strategies in tumor treatment. Optical microfibers, which have engineerable waveguiding properties, are highly attractive for optical sensing and photothermal therapy on the micro/nanoscale. However, for their real‐world application, the sensitivity limit needs to be addressed, as does the issue of improving the intrinsic photothermal performance of silica microfibers. Herein, a nanointerface consisting of triangular Au@Ag2S nanoplates and VO2 nanoparticles on an optical microfiber is designed to fabricate a structurally resilient hierarchical microfiber sensor with well‐distributed plasmonic hotspot enhancement. The nanointerface enhances the evanescent field with temperature tunability, adding a self‐photothermal modulation function to the sensor. The sensor exhibits a temperature‐tunable sensitivity to alpha‐fetoprotein with a limit of detection of 0.62 × 10−18 m. It differentiates hepatoma carcinoma cells from normal cells and provides photothermal therapy aimed at the former. Quantitative evaluation of the sensor indicates that photothermal therapy kills more than 82% of cancer cells using a lower power. This work provides a new opportunity for selective evanescent field modulation for evanescent biosensors as well as a potential approach to the integration of cellular diagnosis and therapy.
Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine‐Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles
Authors: Wang Tingting , Zhang Hao , Han Yaobao , Zheng Qing , Liu Hanghang , Han Mengxiao , Li Zhen 
Published: January 2023

AbstractT cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It is crucial to innovatively reverse the T cell dysfunction for improving GBM immunotherapy. Herein, T cell dysfunction is remarkably reversed and immunotherapy of GBM is boosted by repurposing the U. S. Food and Drug Administration‐approved antidepressant paroxetine (PX) with biomimetic nanoparticles (CS‐J@CM/6 NPs). The PX is successfully applied to abrogate T cell sequestration in the bone marrow of GBM‐bearing mice and increase their infiltration in tumor. The biomimetic NPs are composed of ultrasmall Cu2−xSe NPs, JQ1, and tumor cell membrane modified with CD6, and are efficiently delivered into tumor through the specific interactions between CD6 and activated leukocyte cell adhesion molecule. They ameliorate the T cell dysfunction through the double roles of loaded JQ1, which simultaneously decreases the expression of PD‐1 and TIM‐3 on T cells, and the expression of PD‐L1 on tumor cells. The NP also induces the immunogenic cell death of tumor cells to activate immune response. The synergistic roles of PX and biomimetic CS‐J@CM/6 NPs notably enhance the survival of GBM‐bearing mice. This work provides new insights into tumor immunotherapy by repurposing “old drugs” with advanced NPs.
Wireless Self‐Powered Optogenetic System for Long‐Term Cardiac Neuromodulation to Improve Post‐MI Cardiac Remodeling and Malignant Arrhythmia
Authors: Zhou Liping , Zhang Yuanzheng , Cao Gang , Zhang Chi , Zheng Chen , Meng Guannan , Lai Yanqiu , Zhou Zhen , Liu Zhihao , Liu Zihan , Guo Fuding , Dong Xin , Liang Zhizhuo , Wang Yueyi , Guo Shishang , Zhou Xiaoya , Jiang Hong , Yu Lilei 
Published: January 2023

AbstractAutonomic imbalance is an important characteristic of patients after myocardial infarction (MI) and adversely contributes to post‐MI cardiac remodeling and ventricular arrhythmias (VAs). A previous study proved that optogenetic modulation could precisely inhibit cardiac sympathetic hyperactivity and prevent acute ischemia‐induced VAs. Here, a wireless self‐powered optogenetic modulation system is introduced, which achieves long‐term precise cardiac neuromodulation in ambulatory canines. The wireless self‐powered optical system based on a triboelectric nanogenerator is powered by energy harvested from body motion and realized the effective optical illumination that is required for optogenetic neuromodulation (ON). It is further demonstrated that long‐term ON significantly mitigates MI‐induced sympathetic remodeling and hyperactivity, and improves a variety of clinically relevant outcomes such as improves ventricular dysfunction, reduces infarct size, increases electrophysiological stability, and reduces susceptibility to VAs. These novel insights suggest that wireless ON holds translational potential for the clinical treatment of arrhythmia and other cardiovascular diseases related to sympathetic hyperactivity. Moreover, this innovative self‐powered optical system may provide an opportunity to develop implantable/wearable and self‐controllable devices for long‐term optogenetic therapy.
The Interaction of 2D Materials With Circularly Polarized Light
Authors: Rong Rong , Liu Ying , Nie Xuchen , Zhang Wei , Zhang Zhuhua , Liu Yanpeng , Guo Wanlin 
Published: January 2023

Abstract2D materials (2DMs), due to spin‐valley locking degree of freedom, exhibit strongly bound exciton and chiral optical selection rules and become promising material candidates for optoelectronic and spin/valleytronic devices. Over the last decade, the manifesting of 2D materials by circularly polarized lights expedites tremendous fascinating phenomena, such as valley/exciton Hall effect, Moiré exciton, optical Stark effect, circular dichroism, circularly polarized photoluminescence, and spintronic property. In this review, recent advance in the interaction of circularly polarized light with 2D materials covering from graphene, black phosphorous, transition metal dichalcogenides, van der Waals heterostructures as well as small proportion of quasi‐2D perovskites and topological materials, is overviewed. The confronted challenges and theoretical and experimental opportunities are also discussed, attempting to accelerate the prosperity of chiral light‐2DMs interactions.
Quantitative Regulation of Interlayer Space of NH4V4O10 for Fast and Durable Zn2+ and NH4+ Storage
Authors: Li Shuyue , Yu Dongxu , Liu Jingyi , Chen Nan , Shen Zexiang , Chen Gang , Yao Shiyu , Du Fei 
Published: January 2023

AbstractLayered vanadium‐based oxides are the promising cathode materials for aqueous zinc‐ion batteries (AZIBs). Herein, an in situ electrochemical strategy that can effectively regulate the interlayer distance of layered NH4V4O10 quantitatively is proposed and a close relationship between the optimal performances with interlayer space is revealed. Specifically, via increasing the cutoff voltage from 1.4, 1.6 to 1.8 V, the interlayer space of NH4V4O10 can be well‐controlled and enlarged to 10.21, 11.86, and 12.08 Å, respectively, much larger than the pristine one (9.5 Å). Among them, the cathode being charging to 1.6 V (NH4V4O10‐C1.6), demonstrates the best Zn2+ storage performances including high capacity of 223 mA h g−1 at 10 A g−1 and long‐term stability with capacity retention of 97.5% over 1000 cycles. Such superior performances can be attributed to a good balance among active redox sites, charge transfer kinetics, and crystal structure stability, enabled by careful control of the interlayer space. Moreover, NH4V4O10‐C1.6 delivers NH4+ storage performances whose capacity reaches 296 mA h g−1 at 0.1 A g−1 and lifespan lasts over 3000 cycles at 5 A g−1. This study provides new insights into understand the limitation of interlayer space for ion storage in aqueous media and guides exploration of high‐performance cathode materials.
High Pressure‐Driven Magnetic Disorder and Structural Transformation in Fe3GeTe2: Emergence of a Magnetic Quantum Critical Point
Authors: Dang Ngoc‐Toan , Kozlenko Denis P. , Lis Olga N. , Kichanov Sergey E. , Lukin Yevgenii V. , Golosova Natalia O. , Savenko Boris N. , Duong Dinh‐Loc , Phan The‐Long , Tran Tuan‐Anh , Phan Manh‐Huong 
Published: January 2023

AbstractAmong the recently discovered 2D intrinsic van der Waals (vdW) magnets, Fe3GeTe2 (FGT) has emerged as a strong candidate for spintronics applications, due to its high Curie temperature (130 – 220 K) and magnetic tunability in response to external stimuli (electrical field, light, strain). Theory predicts that the magnetism of FGT can be significantly modulated by an external strain. However, experimental evidence is needed to validate this prediction and understand the underlying mechanism of strain‐mediated vdW magnetism in this system. Here, the effects of pressure (0 – 20 GPa) are elucidated on the magnetic and structural properties of Fe3GeTe2 by means of synchrotron Mössbauer source spectroscopy, X‐ray powder diffraction and Raman spectroscopy over a wide temperature range of 10 – 290 K. A strong suppression of ferromagnetic ordering is observed with increasing pressure, and a paramagnetic ground state emerges when pressure exceeds a critical value, PPM ≈ 15 GPa. The anomalous pressure dependence of structural parameters and vibrational modes is observed at PC ≈ 7 GPa and attributed to an isostructural phase transformation. Density functional theory calculations complement these experimental findings. This study highlights pressure as a driving force for magnetic quantum criticality in layered vdW magnetic systems.
Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films
Authors: Han Yangyang , Cao Yiping , Zhou Jiangtao , Yao Yang , Wu Xiaodong , Bolisetty Sreenath , Diener Michael , Handschin Stephan , Lu Canhui , Mezzenga Raffaele 
Published: January 2023

AbstractAmyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a facile and general methodology to fabricate macroscopic and tunable amyloid films via fast electrostatic self‐assembly of amyloid fibrils at the air–water interface is introduced. Benefiting from the excellent templating properties of amyloid fibrils for nanoparticles (such as conductive carbon nanotubes or magnetic Fe3O4 nanoparticles), multifunctional amyloid films with tunable properties are constructed. As proof‐of‐concept demonstrations, a magnetically oriented soft robotic swimmer with well‐confined movement trajectory is prepared. In addition, a smart magnetic sensor with high sensitivity to external magnetic fields is fabricated via the combination of the conductive and magnetic amyloid films. This strategy provides a convenient, efficient, and controllable approach for the preparation of amyloid‐based multifunctional films and related smart devices.
High Performance of Normally‐On and Normally‐Off Devices with Highly Boron‐Doped Source and Drain on H‐Terminated Polycrystalline Diamond
Authors: Zhu Xiaohua , Shao Siwu , Chan Siyi , Tu Juping , Ota Kosuke , Huang Yabo , An Kang , Chen Liangxian , Wei Junjun , Liu Jinlong , Li Chengming , Kawarada Hiroshi 
Published: January 2023

AbstractDiamond exhibits large application potential in the field of power electronics, owing to its excellent and desirable electronic properties. However, the main obstacles to its development originate from the small‐sized single‐crystal wafers and the instability of the electrical conductivity. This work presents a metal‐oxide‐semiconductor field‐effect transistor (MOSFET) on a diamond substrate derived from a five‐inch (110) highly preferred polycrystalline diamond film. The MOSFETs with excellent performance are fabricated by combining an H‐terminated channel and an epitaxially grown boron‐doped layer as the source/drain contacts of the diamond devices. According to the electrical statistical results of ≈110 devices on the polycrystalline diamond substrate, 44% of devices show normally‐off operation with a maximum current density of 400 mA mm−1, while 56% of devices demonstrate normally‐on operation with a maximum current density of 525 mA mm−1. The normally‐off characteristics are more related to the higher amounts of nitrogen concentration than the grain boundaries. The stable boron‐doped source and drain provide a high concentration of holes, which facilitate transport in the surface p‐type channel induced by the H‐termination. The characteristics of the MOSFETs are inspiring for the fabrication of complementary inverter circuits on large diamond wafers.
Ultra‐Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II
Authors: Kim Ja Hye , Park Ji‐Hyung , Lee Junehawk , Park Jung Woo , Kim Hyun Jung , Chang Won Seok , Kim Dong‐Seok , Ju Young Seok , Aronica Eleonora , Lee Jeong Ho 
Published: January 2023

ObjectiveBrain somatic mutations in mTOR pathway genes are a major genetic etiology of focal cortical dysplasia type II (FCDII). Despite a greater ability to detect low‐level somatic mutations in the brain by deep sequencing and analytics, about 40% of cases remain genetically unexplained.MethodsWe included 2 independent cohorts consisting of 21 patients with mutation‐negative FCDII without apparent mutations on conventional deep sequencing of bulk brain. To find ultra‐low level somatic variants or structural variants, we isolated cells exhibiting phosphorylation of the S6 ribosomal protein (p‐S6) in frozen brain tissues using fluorescence‐activated cell sorting (FACS). We then performed deep whole‐genome sequencing (WGS; >90×) in p‐S6+ cells in a cohort of 11 patients with mutation‐negative. Then, we simplified the method to whole‐genome amplification and target gene sequencing of p‐S6+ cells in independent cohort of 10 patients with mutation‐negative followed by low‐read depth WGS (10×).ResultsWe found that 28.6% (6 of 21) of mutation‐negative FCDII carries ultra‐low level somatic mutations (less than 0.2% of variant allele frequency [VAF]) in mTOR pathway genes. Our method showed ~34 times increase of the average mutational burden in FACS mediated enrichment of p‐S6+ cells (average VAF = 5.84%) than in bulky brain tissues (average VAF = 0.17%). We found that 19% (4 of 21) carried germline structural variations in GATOR1 complex undetectable in whole exome or targeted gene sequencing.ConclusionsOur method facilitates the detection of ultra‐low level somatic mutations, in specifically p‐S6+ cells, and germline structural variations and increases the genetic diagnostic rate up to ~80% for the entire FCDII cohort. ANN NEUROL 2023;93:1082–1093
High performance, low‐fouling nanocomposite membrane with TiO2 nanomaterial in polysulfone matrix for advanced water treatment
Authors: Sharma Ritika , Galav Prashant , Raval Hiren D. 
Published: January 2023

AbstractIn the present article, nanocomposite TiO2/polysulfone membranes were prepared for advanced water treatment and removal of surfactant and dye from water were evaluated. The nanocomposite membranes demonstrated enhanced antifouling properties. Scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, atomic force microscopy, and transmission electron microscopy were conducted to characterize particles and fabricated nanocomposite membranes. The antifouling characteristics of the membrane were assessed by ultrafiltration of model foulants such as sodium alginate and egg albumin and it was found that the nanocomposite membranes were less prone to fouling. Separation performance of Congo red dye and non‐ionic surfactant Triton X‐100 were evaluated and the nanocomposite membranes have shown encouraging results. With incorporation of TiO2 nanoparticles, ultimate tensile strength increased while elongation at break decreased. Decrement in pore size with incorporation of nanomaterial and change in surface characteristics were responsible for improved performance of membrane.
Assessment of neuropathic pain following cancer treatment
Authors: Moloney Niamh A. , Lenoir Dorine 
Published: January 2023

AbstractNeuropathic cancer pain (NCP) is prevalent affecting up to 58% of those with persistent pain following cancer treatment. Neuropathic pain can develop from malignancy, after neural tissue insult during surgery and/or exposure to radiation or neurotoxic agents used as part of cancer treatment regimens. Pain following cancer treatment is commonly under‐treated and one barrier identified is poor recognition of pain and inadequate assessment. Recognition of the presence of NCP is important to inform pain management, which is challenging to treat and warrants the use of specific treatments to target neuropathic mechanisms. In this review, approaches for screening and classifying NCP are described. These include screening questionnaires and the application of the updated neuropathic pain grading system in a cancer context. The evidence from neuropathic pain related assessments in cancer populations is provided and highlighted under different neuropathic pain grades. Recommendations for assessment in practice are provided.
Multiwavelength astrophysics of the blazar OJ 287 and the project MOMO
Authors: Komossa S. , Kraus A. , Grupe D. , Parker M.L. , Gonzalez A. , Gallo L.C. , Gurwell M.A. , Laine S. , Yao S. , Chandra S. , Dey L. , Gómez J.L. , Hada K. , Haggard D. , Hollett A.R. , Jermak H. , Jorstad S. , Krichbaum T.P. , Markoff S. , McCall C. , Neilsen J. , Nowak M. 
Published: January 2023

AbstractWe are carrying out the densest and longest multiyear, multiwavelength monitoring project of OJ 287 ever done. The project MOMO (Multiwavelength Observations and Modeling of OJ 287) covers wavelengths from the radio to the high‐energy regime. A few selected observations are simultaneous with those of the Event Horizon Telescope (EHT). MOMO aims at understanding disk‐jet physics and at testing predictions of the binary black hole scenario of OJ 287. Here, we present a discussion of extreme outburst and minima states in context, and then focus on the recent flux and spectral evolution between 2021 and May 2022, including an ongoing bright radio flare. Further, we show that there is no evidence for precursor flare activity in our optical–UV–X‐ray light curves that would be associated with any secondary supermassive black hole (SMBH) disk impact and that was predicted to start as thermal flare on December 23, 2021.
Balancing Partial Ionic and Electronic Transport for Optimized Cathode Utilization of High‐Voltage LiMn2O4/Li3InCl6 Solid‐State Batteries
Authors: Hendriks Theodoor A. , Lange Martin A. , Kiens Ellen M. , Baeumer Christoph , Zeier Wolfgang G. 
Published: January 2023

AbstractTheir suggested stability towards high‐voltage cathode materials makes halide‐based solid electrolytes currently an interesting class of ionic conductors for solid‐state batteries. Especially the LiMn2O4 spinel cathode active material is of interest due to its slightly higher nominal voltage and more resilience to overcharging compared to LiCoO2 and LiNixMnyCozO2 cathodes. Typically, a standard ratio of active material to solid electrolyte is used in composites for solid‐state batteries. However, for ideal transport properties, and thus to achieve balanced and optimal partial‐conductivities, this ratio needs to be re‐optimized each time the material basis is changed. In this work, we show transport in the composite measured through both DC polarization as well as transmission line modeling of the impedance spectra. By balancing the partial transport parameters of the composite, an optimum capacity of the solid‐state batteries is achieved. This work shows characterization and optimization of transport is required for unlocking the full potential of solid‐state batteries.
1,2,3‐Triazole analogs with bulky and conformationally rigid substructures: Synthesis and in vitro evaluation as DPP‐4 inhibitors
Authors: Vo Duy‐Viet , Lee Jongkook , Park Haeil 
Published: January 2023

AbstractNovel 1,2,3‐triazole analogs with bulky and conformationally rigid azacyclic/azabicyclic amine and alcohol substructures at the C4 position were synthesized and evaluated for their inhibitory activities against human dipeptidyl peptidase‐4 enzyme. The synthesized 1,2,3‐triazole analogs (2a–2f) exhibited moderate in vitro hDPP‐4 inhibitory activities (0.32–>2.0 μM) in comparison to the analog with the C4 tert‐Bu group (0.24 μM). However, the reduced bioactivity of the 1,2,3‐triazole analogs with bulky and conformationally rigid substructures might be attributed to the lower‐than‐anticipated van der Waals interactions of the introduced heterocycles. Another plausible explanation for the reduced activity could be due to the role of two other factors (π–π interaction and H‐bonding) in influencing the interaction of the analogs with the key amino residues in the pocket of the enzyme. Further research is encouraged to explore the role of these factors in deciding the enzyme‐inhibiting activities of the C4 substituted 1,2,3‐triazole analogs.
Balanced scorecard and eco‐innovation in the industrial sector: A strategic map for environmental innovation
Authors: Osório de Andrade Guerra José Baltazar Salgueirinho , Schneider Jonas , Andrade De Lima Mauricio , Peixoto Maria Gabriela M. , Barbosa Samuel Borges , da Silva Neiva Samara , Birch Robert , Sampaio de Jesus Marco Antonio , Junges Ivone , de Aguiar Dutra Ana Regina 
Published: January 2023

AbstractIn recent years, companies in several industries have adhered to new initiatives, developed new technologies and industrial processes to help reduce pollution and address other factors that have negative impacts on the environment. However, there is a lack of practical methodologies to evaluate the environmental performance of an organization, and there is no appropriate methodology to help companies direct their investment strategies to achieve corporate sustainability. An eco‐innovation plan is an important tool to help industries become more environmentally friendly, but its implementation is difficult to achieve in the short term. To this end, this article offers a strategic eco‐innovation map based on the well‐known balanced scorecard (BSC) that aims to help companies mitigate environmental impacts and promote sustainable development without harming their development and growth. Based on a review of the relevant literature and a survey of 30 environmental experts using four dimensions and 38 indicators, the map provides a methodological path for the investment in environmental sustainability initiatives and programs with financial returns.