bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement noise level of E-bus HIGER KLQ6125GEV3 on the polygon
Authors: Misanovic S , Taranovic D , Maljkovic M , Milicic B 
Published: December 2022

Abstract
Buses for public city transport in cities represent a significant source of noise, especially in the central city zones, on the traffic corridors with the highest hourly frequencies of public transport vehicles. The introduction of electric buses is one of the possible ways to reduce noise. The paper will present the results of the experimental measurement of noise levels of e-bus Higer KLQ6125GEV3 on the polygon, using the Lutron SL-4001 measuring instrument, following UN ECE 51.02 regulations and a comparison with the results of noise levels measurement with buses on diesel and CNG driveline.
Examining the surface roughness and kerf quality of micro-slots cut on the surfaces of Ti-B4C nanocomposites by WEDM: a desirability approach
Authors: Ragavan G Vijaya Raja , Lakshmanan Poovazhagan , Mahalingam Mariyappan 
Published: December 2022

Abstract
Micro slots and textures are created on Titanium (Ti) composites to improve its surface characteristics. Micro-textured Ti composites are generally recommended for bio implants, automobile, and aerospace components. In the current research, Ti-B4C nanocomposites were prepared by powder metallurgical route. Micro slots were cut on the Ti-B4C surfaces by Wire Electrical Discharge Machining (WEDM) Technology by varying the current, pulse-ON time, and pulse-OFF time. Scanning electron microscopy and XRD analysis validates the uniform distribution and inclusion of B4C nanoparticles in Ti matrix. Response surface methodology was used to plan the experimental runs. Analysis of variance and desirability analysis were employed to identify the most suitable machining factors for obtaining the minimum surface roughness, lower kerf width and higher material removal rate (MRR). Increase in applied current and pulse-ON time, increases the MRR. Increase of pulse-OFF time from 50 μs to 60 μs gradually reduces the MRR and reduce the surface roughness of the cut slots. Contrastingly an increase in pulse-ON time increases the roughness due to an extensive melting and resolidification of Ti nanocomposites. The morphology of the WEDMed surface reveals the recast layer and localized melting zones on the cut surfaces.
Development of WS2/MXene (Ti3C2T
x
) nanohybrid based multi-functional textronic sensor for non-invasive personal healthcare monitoring
Authors: Adepu Vivek , Tathacharya Manav , Mattela Venkat , Sahatiya Parikshit 
Published: December 2022

Abstract
This report demonstrates the development of a WS2/Ti3C2T
X
nanohybrid-based multifunctional physical sensor (pressure, strain, and humidity) on a textile cloth. The fabricated sensor demonstrates excellent sensitivity and gauge factor of 3.66198 kPa−1, 3.17119, and 1.61787 towards pressure, strain, and humidity stimuli, respectively, with exceptional long-term stability showing an insignificant change in performance over ∼4000 and ∼4200 cycles. The underlying transduction mechanism for the fabricated piezoresistive multifunctional physical sensor is explained utilizing the intrinsic piezoresistive effect as well as the modulation of the Schottky barrier height exhibited by the WS2/Ti3C2T
x
at the local heterojunctions with the help of detailed band structures that are realized by ultraviolet photoelectron spectroscopy. A smartphone-based application was established to authenticate wireless incorporation of the fabricated multifunctional physical sensors to demonstrate applications such as tetraplegic call detection, mood detection, and dry/wet skin monitoring system. The successful demonstration of connected healthcare applications using the WS2/Ti3C2T
x
multifunctional sensor opens up new possibilities and applications in the fields of smart healthcare, e-textiles, and flexible electronics.
Biomaterials of human source for 3D printing strategies
Authors: Maia João Rocha , Sobreiro-Almeida Rita , Cleymand Franck , Mano João F 
Published: December 2022

Abstract
Three-dimensional printing has risen in recent years as a promising approach that fast-tracked the biofabrication of tissue engineering constructs that most resemble utopian tissue/organ replacements for precision medicine. Additionally, by using human-sourced biomaterials engineered towards optimal rheological proprieties of extrudable inks, the best possible scaffolds can be created. These can encompass native structure and function with a low risk of rejection, enhancing overall clinical outcomes; and even be further optimized by engaging in information- and computer-driven design workflows. This paper provides an overview of the current efforts in achieving ink’s necessary rheological and print performance proprieties towards biofabrication from human-derived biomaterials. The most notable step for arranging such characteristics to make biomaterials inks are the employed crosslinking strategies, for which examples are discussed. Lastly, this paper illuminates the state-of-the-art of the most recent literature on already used human-sourced inks; with a final emphasis on future perspectives on the field.
Device engineering of organic solar cells based on a boron subphthalocyanine electron donor molecule
Authors: Ahmadpour Mehrad , Prete Michela , Aryal Um Kanta , Petersen Anne Ugleholdt , Ahmad Mariam , Rubahn Horst-Günter , Jespersen Malte F , Mikkelsen Kurt V , Turkovic Vida , Nielsen Mogens Brøndsted , Madsen Morten 
Published: December 2022

Abstract
A boron subphthalocyanine molecule has been employed as a novel electron donor in organic solar cells (OPVs), and optimized in terms of composition and device structure in small molecule solar cells. It is demonstrated that the power conversion efficiency (PCE) of the devices obtained by solution-processing in bulk heterojunction solar cells could be improved by one order of magnitude by changing the fabrication method to vacuum deposition, which promotes a better morphology in the OPV active layers. Importantly, upon insertion of an additional pristine C70 thin interlayer between the active layer and the hole transport layer the PCE was further improved, highlighting the importance of interfacial layer engineering in such subphthalocyanine small molecule OPVs.
On the eigenvalue problem of Schrödinger-Poisson system
Authors: Liu Zhisu 
Published: December 2022

In this paper, we are concerned with the following Schrödinger-Poisson system with nonhomogeneous boundary conditions

{

−

1
2

△

u

+
ϕ
u
=
ω
u
,

a
m
p
;
in
Ω
,

−
△

ϕ

=
4
π

u
2

,

a
m
p
;
in
Ω
,

ϕ
=
h
,
u
=
0
,

a
m
p
;
on
∂
Ω
,

\begin{equation*} \begin {cases} -\frac {1}{2}\triangle {u}+\phi u =\omega u, & \text {in }\Omega , \\ -\triangle {\phi }=4\pi u^2, & \text {in } \Omega ,\\ \phi =h,u=0, & \text {on } \partial \Omega , \end{cases} \end{equation*}

where

Ω
\Omega

is a smooth and bounded domain in

R

3

\mathbb {R}^3

,

h
h

is a given nonnegative regular function on

∂
Ω

\partial \Omega

and

ω
∈

R

\omega \in \mathbb {R}

. By using variational method and bifurcation theory, we obtain the existence of positive solutions to the above system for

ω
\omega

larger than some positive constant.
Dependent censoring based on parametric copulas
Authors: Czado C , Van Keilegom I 
Published: December 2022

Summary
Consider a survival time $T$ that is subject to random right censoring, and suppose that $T$ is stochastically dependent on the censoring time $C$. We are interested in the marginal distribution of $T$. This situation is often encountered in practice. Consider, for example, the case where $T$ is a patient’s time to death from a certain disease. Then the censoring time $C$ could be the time until the patient leaves the study or the time until death from another cause. If the reason for leaving the study is related to the health condition of the patient, or if the patient dies from a disease that has similar risk factors to the disease of interest, then $T$ and $C$ are likely to be dependent. In this paper we propose a new model that takes such dependence into account. The model is based on a parametric copula for the relationship between $T$ and $C$, and on parametric marginal distributions for $T$ and $C$. Unlike most other authors, we do not assume that the parameter defining the copula is known. We give sufficient conditions on these parametric copulas and marginals under which the bivariate distribution of $(T,C)$ is identified. These sufficient conditions are then checked for a wide range of common copulas and marginals. We also study the estimation of the model, and carry out extensive simulations and analysis on a pancreatic cancer dataset to illustrate the proposed model and estimation procedure.
Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory
Authors: de Leo Gioacchino , Gulino Rosario , Coradazzi Marino , Leanza Giampiero 
Published: December 2022

AbstractSevere loss of cholinergic neurons in the basal forebrain nuclei and of noradrenergic neurons in the locus coeruleus are almost invariant histopathological hallmarks of Alzheimer’s disease. However, the role of these transmitter systems in the spectrum of cognitive dysfunctions typical of the disease is still unclear, nor is it yet fully known whether do these systems interact and how. Selective ablation of either neuronal population, or both of them combined, were produced in developing animals to investigate their respective and/or concurrent contribution to spatial learning and memory, known to be severely affected in Alzheimer’s disease. Single or double lesions were created in 4–8 days old rats by bilateral intraventricular infusion of two selective immunotoxins. At about 16 weeks of age, the animals underwent behavioural tests specifically designed to evaluate reference and working memory abilities, and their brains were later processed for quantitative morphological analyses. Animals with lesion to either system alone showed no significant reference memory deficits which, by contrast, were evident in the double-lesioned subjects. These animals could not adopt an efficient search strategy on a given testing day and were unable to transfer all relevant information to the next day, suggesting deficits in acquisition, storage and/or recall. Only animals with single noradrenergic or double lesions exhibited impaired working memory. Interestingly, ablation of cholinergic afferents to the hippocampus stimulated a robust ingrowth of thick fibres from the superior cervical ganglion which, however, did not appear to have contributed to the observed cognitive performance. Ascending cholinergic and noradrenergic afferents to the hippocampus and neocortex appear to be primarily involved in the regulation of different cognitive domains, but they may functionally interact, mainly at hippocampal level, for sustaining normal learning and memory. Moreover, these transmitter systems are likely to compensate for each other, but apparently not via ingrowing sympathetic fibres.
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc
Min/+ mice: possible mechanisms of radiation tumorigenesis
Authors: Sasatani Megumi , Shimura Tsutomu , Doi Kazutaka , Zaharieva Elena Karamfilova , Li Jianxiang , Iizuka Daisuke , Etoh Shinpei , Sotomaru Yusuke , Kamiya Kenji 
Published: December 2022

Abstract
Age at exposure is a major modifier of radiation-induced carcinogenesis. We used mouse models to elucidate the mechanism underlying age-related susceptibility to radiation-induced tumorigenesis. Radiation exposure in infants was effective at inducing tumors in B6/B6-Chr18MSM-F1 ApcMin/+ mice. Loss of heterozygosity analysis revealed that interstitial deletion may be considered a radiation signature in this model and tumor number containing a deletion correlated with the susceptibility to radiation-induced tumorigenesis as a function of age. Furthermore, in Lgr5-eGFP-ires-CreERT2; Apcflox/flox mice, deletions of both floxed Apc alleles in Lgr5-positive stem cells in infants resulted in the formation of more tumors than in adults. These results suggest that tumorigenicity of Apc-deficient stem cells varies with age and is higher in infant mice. Three-dimensional immunostaining analyses indicated that the crypt architecture in the intestine of infants was immature and different from that in adults concerning crypt size and the number of stem cells and Paneth cells per crypt. Interestingly, the frequency of crypt fission correlated with the susceptibility to radiation-induced tumorigenesis as a function of age. During crypt fission, the percentage of crypts with lysozyme-positive mature Paneth cells was lower in infants than that in adults, whereas no difference in the behavior of stem cells or Paneth cells was observed regardless of age. These data suggest that morphological dynamics in intestinal crypts affect age-dependent susceptibility to radiation-induced tumorigenesis; oncogenic mutations in infant stem cells resulting from radiation exposure may acquire an increased proliferative potential for tumor induction compared with that in adults.
Ethical challenges for a community-based researcher: a case study from Bihar, India
Authors: Khatoon Shakila , Kumar Neerajha Krishna 
Published: December 2022

Abstract
The case study is based on a first-person account of the experiences of a community researcher in India involved in community-based participatory development. It highlights the ethical stances taken by the community researcher during primary research that was carried out in remote villages in the state of Bihar among members of a denotified tribal community. It highlights her journey of reflecting on the research engagement, from an ethical perspective, after her engagement in an ethical review committee constituted by the Praxis Institute of Participatory Practices (herein, referred to as Praxis). The case study maps the journey of the researcher and the intrinsic and extrinsic motivations that led her to reflect on her ethical practices while carrying out community research. It also highlights the reflexivity of the researcher during her journey of the research process.
Phenotyping the late- and younger-onset neuronal surface antibody-mediated autoimmune encephalitis: a multicenter study
Authors: Cai Meng-Ting , Zheng Yang , Lai Qi-Lun , Fang Gao-Li , Shen Chun-Hong , Ding Mei-Ping , Zhang Yin-Xi 
Published: December 2022

AbstractNeuronal surface antibody-mediated autoimmune encephalitis (NSAE) occurs across a wide age range. However, few studies focused on the onset age and their related characteristics. We aimed to explore the age-dependent profile of NSAE. A total of 134 patients with a definite diagnosis of NSAE were retrospectively enrolled from 3 tertiary hospitals between July 2014 and August 2020. Demographic, clinical, therapeutic, and prognostic data were collected and compared between the late- (≥45) and younger-onset (&lt;45) groups. The results showed that 56 (41.8%) patients were classified as late-onset NSAE, and 78 (58.2%) as younger-onset NSAE. There were more males, especially in the late-onset group (P = 0.036). Prodromal symptoms were more common in the younger-onset group (P = 0.004). Among the onset symptoms, more late-onset patients presented as seizures, while more younger-onset patients presented as psychiatric symptoms. Throughout the disease course, the late-onset patients were more likely to have memory dysfunction (P &lt; 0.001), but less likely to have central hypoventilation (P = 0.045). The late-onset patients also had a significantly lower modified Rankin Scale score on admission (P = 0.042), required intensive care unit (ICU) admission less frequently during hospitalization (P = 0.042) and had a shorter hospital stay (P = 0.014). Our study revealed that the late- and younger-onset NSAE had a distinct spectrum of demographic features, presentations, and prognoses. More attention is needed for the younger-onset patients, given a higher disease severity on admission, more frequent requirement for ICU admission and longer length of stay.
Endothelial progenitor cell mobilization based on exercise volume in patients with cardiovascular disease and healthy individuals: a systematic review and meta-analysis
Authors: Mitsiou Georgios , Tokmakidis Savvas P , Dinas Petros C , Smilios Ilias , Nanas Serafeim 
Published: December 2022

Abstract
Endothelial progenitor cells (EPCs) play a vital role in protecting endothelial dysfunction and cardiovascular disease (CVD). Physical exercise stimulates the mobilization of EPCs, and along with vascular endothelial growth factor (VEGF), promotes EPC differentiation, and contributes to vasculogenesis. The present meta-analysis examines the exercise-induced EPC mobilization and has an impact on VEGF in patients with CVD and healthy individuals. Database research was conducted (PubMed, EMBASE, Cochrane Library of Controlled Trials) by using an appropriate algorithm to indicate the exercise-induced EPC mobilization studies. Eligibility criteria included EPC measurements following exercise in patients with CVD and healthy individuals. A continuous random effect model meta-analysis (PROSPERO-CRD42019128122) was used to calculate mean differences in EPCs (between baseline and post-exercise values or between an experimental and control group). A total of 1460 participants (36 studies) were identified. Data are presented as standard mean difference (Std.MD) and 95% confidence interval (95% CI). Aerobic training stimulates the mobilization of EPCs and increases VEGF in patients with CVD (EPCs: Std.MD: 1.23, 95% CI: 0.70–1.76; VEGF: Std.MD: 0.76, 95% CI:0.16–1.35) and healthy individuals (EPCs: Std.MD: 1.11, 95% CI:0.53–1.69; VEGF: Std.MD: 0.75, 95% CI: 0.01-1.48). Acute aerobic exercise (Std.MD: 1.40, 95% CI: 1.00–1.80) and resistance exercise (Std.MD: 0.46, 95%CI: 0.10–0.82) enhance EPC numbers in healthy individuals. Combined aerobic and resistance training increases EPC mobilization (Std.MD:1.84, 95% CI: 1.03–2.64) in patients with CVD. Adequate exercise volume (&gt;60%VO2max &gt;30 min; P = 0.00001) yields desirable results. Our meta-analysis supports the findings of the literature. Exercise volume is required to obtain clinically significant results. Continuous exercise training of high-to-moderate intensity with adequate duration as well as combined training with aerobic and resistance exercise stimulates EPC mobilization and increases VEGF in patients with CVD and healthy individuals.
High-intensity interval training induces beneficial effects on coronary atheromatous plaques: a randomized trial
Authors: Vesterbekkmo Elisabeth Kleivhaug , Aksetøy Inger-Lise Aamot , Follestad Turid , Nilsen Hans Olav , Hegbom Knut , Wisløff Ulrik , Wiseth Rune , Madssen Erik 
Published: December 2022

AbstractAimsCoronary atheroma volume is associated with risk of coronary events in coronary artery disease (CAD). Exercise training is a cornerstone in primary and secondary prevention of CAD, but the effect of exercise on coronary atheromatous plaques is largely unknown. We assessed the effect of 6 months supervised high-intensity interval training (HIIT) on coronary plaque geometry using intravascular ultrasound in patients with stable CAD following percutaneous coronary intervention (PCI).Methods and resultsSixty patients were randomized to two sessions of weekly supervised HIIT at 85–95% of peak heart rate (n = 30) or to follow contemporary preventive guidelines (control group, n = 30). The study endpoints were change in percent atheroma volume (PAV) and total atheroma volume (TAV) normalized for segment length (TAVnorm) at 6-month follow-up. The change in average PAV for matched coronary segments from baseline to follow-up showed a significant between-group difference (−1.4, 95% CI: −2.7 to −0.1, P = 0.036). There was a significant reduction in the HIIT group (−1.2, 95% CI: −2.1 to −0.2, P = 0.017) while not in the control group (0.2, 95% CI: −0.7 to 1.1, P = 0.616). TAVnorm was reduced (−9 mm3, 95% CI: −14.7 to −3.4, P = 0.002) after HIIT, with a significant between-group difference (−12.0 mm3, 95% CI: −19.9 to −4.2, P = 0.003).ConclusionIn patients with established CAD, a regression of atheroma volume was observed in those undergoing 6 months of supervised HIIT compared with patients following contemporary preventive guidelines. Our study indicates that HIIT counteracts atherosclerotic coronary disease progression and reduces atheroma volume in residual coronary atheromatous plaques following PCI.
The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in bacteria
Authors: Norris Vic , Kayser Clara , Muskhelishvili Georgi , Konto-Ghiorghi Yoan 
Published: December 2022

Abstract
How to adapt to a changing environment is a fundamental, recurrent problem confronting cells. One solution is for cells to organize their constituents into a limited number of spatially extended, functionally relevant, macromolecular assemblies or hyperstructures, and then to segregate these hyperstructures asymmetrically into daughter cells. This asymmetric segregation becomes a particularly powerful way of generating a coherent phenotypic diversity when the segregation of certain hyperstructures is with only one of the parental DNA strands and when this pattern of segregation continues over successive generations. Candidate hyperstructures for such asymmetric segregation in prokaryotes include those containing the nucleoid-associated proteins (NAPs) and the topoisomerases. Another solution to the problem of creating a coherent phenotypic diversity is by creating a growth-environment-dependent gradient of supercoiling generated along the replication origin-to-terminus axis of the bacterial chromosome. This gradient is modulated by transcription, NAPs, and topoisomerases. Here, we focus primarily on two topoisomerases, TopoIV and DNA gyrase in Escherichia coli, on three of its NAPs (H-NS, HU, and IHF), and on the single-stranded binding protein, SSB. We propose that the combination of supercoiling-gradient-dependent and strand-segregation-dependent topoisomerase activities result in significant differences in the supercoiling of daughter chromosomes, and hence in the phenotypes of daughter cells.
Genome assembly of the acoel flatworm Symsagittifera roscoffensis, a model for research on body plan evolution and photosymbiosis
Authors: Martinez Pedro , Ustyantsev Kirill , Biryukov Mikhail , Mouton Stijn , Glasenburg Liza , Sprecher Simon G , Bailly Xavier , Berezikov Eugene 
Published: December 2022

Abstract
Symsagittifera roscoffensis is a well-known member of the order Acoela that lives in symbiosis with the algae Tetraselmis convolutae during its adult stage. Its natural habitat is the eastern coast of the Atlantic, where at specific locations thousands of individuals can be found, mostly, lying in large pools on the surface of sand at low tide. As a member of the Acoela it has been thought as a proxy for ancestral bilaterian animals; however, its phylogenetic position remains still debated. In order to understand the basic structural characteristics of the acoel genome, we sequenced and assembled the genome of aposymbiotic species S. roscoffensis. The size of this genome was measured to be in the range of 910–940 Mb. Sequencing of the genome was performed using PacBio Hi-Fi technology. Hi-C and RNA-seq data were also generated to scaffold and annotate it. The resulting assembly is 1.1 Gb large (covering 118% of the estimated genome size) and highly continuous, with N50 scaffold size of 1.04 Mb. The repetitive fraction of the genome is 61%, of which 85% (half of the genome) are LTR retrotransposons. Genome-guided transcriptome assembly identified 34,493 genes, of which 29,351 are protein coding (BUSCO score 97.6%), and 30.2% of genes are spliced leader trans-spliced. The completeness of this genome suggests that it can be used extensively to characterize gene families and conduct accurate phylogenomic reconstructions.