bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of high-risk patients resistant to CDK4/6 inhibitors with hormone receptor-positive HER2-negative advanced and metastatic breast cancer in Japan (KBCSG-TR-1316)
Authors: Futamura Manabu , Nakayama Takahiro , Yoshinami Tetsuhiro , Oshiro Chiya , Ishihara Mikiya , Morita Midori , Watanabe Akira , Tanigichi Azusa , Tsukabe Masami , Shimoda Masafumi , Nitta Kanae , Chihara Yoko , Yasojima Hiroyuki , Ouchi Yoshimi , Tokumaru Yoshihisa , Masuda Norikazu 
Published: July 2023

Abstract
Background
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) improve the prognosis of hormone receptor-positive HER2-negative advanced/metastatic breast cancer (HR+/HER2− mBC). However, some cancers show resistance to CDK4/6i and have a poor prognosis. The non-luminal disease score (NOLUS) was developed to predict non-luminal disease using immunohistochemical analysis.

Methods
The association between the efficacy of CDK4/6i and NOLUS was investigated by evaluating pathological and clinical data, including real-world progression-free survival (rw-PFS) and overall survival (OS). Real-world data of patients with HR+/HER2− mBC who received CDK4/6i therapy [palbociclib or abemaciclib] as first- or second-line endocrine treatments was obtained. NOLUS was calculated using the formula: NOLUS (0–100) = − 0.45 × estrogen receptor (ER) (%) − 0.28 × progesterone receptor (PR) (%) + 0.27 × Ki67(%) + 73, and the patients were divided into two groups: NOLUS-positive (≥ 51.38) and NOLUS-negative (< 51.38).

Results
Of the 300 patients, 28 (9.3%) were NOLUS-positive, and 272 (90.7%) were NOLUS-negative. The expression rates (%) of ER and PgR in NOLUS-positive patients were lower than those in NOLUS-negative patients (p < 0.001). Ki67 expression was higher in NOLUS-positive patients. There were statistically significant differences in prognosis (rw-PFS and OS) between the two groups. Moreover, NOLUS-negative patients showed statistically better rw-PFS with first-line therapy than second-line therapy. However, NOLUS-positive patients showed poor prognoses with both the first and second therapeutic lines, suggesting CDK4/6i inefficacy for NOLUS-positive patients.

Conclusions
The efficacy and prognosis of CDK4/6i significantly differed between the NOLUS-positive and NOLUS-negative patients. This feasible method can predict patients with HR+/HER2− mBC resistant to CDK4/6i and help select a better therapeutic approach to overcome resistance.
Experimental and numerical investigation of the deep rolling process focussing on 34CrNiMo6 railway axles
Authors: Pertoll Tobias , Buzzi Christian , Dutzler Andreas , Leitner Martin , Seisenbacher Benjamin , Winter Gerhard , Boronkai László 
Published: July 2023

AbstractDeep rolling is a powerful tool to increase the service life or reduce the weight of railway axles. Three fatigue-resistant increasing effects are achieved in one treatment: lower surface roughness, strain hardening and compressive residual stresses near the surface. In this work, all measurable changes introduced by the deep rolling process are investigated. A partly deep-rolled railway axle made of high strength steel material 34CrNiMo6 is investigated experimentally. Microstructure analyses, hardness-, roughness-, FWHM- and residual stress measurements are performed. By the microstructure analyses a very local grain distortion, in the range < 5 µm, is proven in the deep rolled section. Stable hardness values, but increased strain hardening is detected by means of FWHM and the surface roughness is significantly reduced by the process application. Residual stresses were measured using the XRD and HD methods. Similar surface values are proven, but the determined depth profiles deviate. Residual stress measurements have generally limitations when measuring in depth, but especially their distribution is significant for increasing the durability of steel materials. Therefore, a numerical deep rolling simulation model is additionally built. Based on uniaxial tensile and cyclic test results, examined on specimen machined from the edge layer of the railway axle, an elastic–plastic Chaboche material model is parameterised. The material model is added to the simulation model and so the introduced residual stresses can be simulated. The comparison of the simulated residual stress in-depth profile, considering the electrochemical removal, shows good agreement to the measurement results. The so validated simulation model is able to determine the prevailing residual stress state near the surface after deep rolling the railway axle. Maximum compressive residual stresses up to about -1,000 MPa near the surface are achieved. The change from the induced compressive to the compensating tensile residual stress range occurs at a depth of 3.5 mm and maximum tensile residual stresses of + 100 MPa at a depth of 4 mm are introduced. In summary, the presented experimental and numerical results demonstrate the modifications induced by the deep rolling process application on a railway axle and lay the foundation for a further optimisation of the deep rolling process.
The Impact of Digital Mental Health Services on Loneliness and Mental Health: Results from a Prospective, Observational Study
Authors: Magid Kirby , Sagui-Henson Sara J. , Sweet Cynthia Castro , Smith Brooke J. , Chamberlain Camille E. Welcome , Levens Sara M. 
Published: July 2023

Abstract
Background
Loneliness has increased since the COVID-19 pandemic and negatively impacts mental health. This study examined relationships between loneliness and mental health among adults using a digital mental health platform.

Methods
A purposive sample of 919 participants (97% response rate) who were newly enrolled in the platform completed a survey on loneliness, depression, anxiety, well-being, stress, social support, and comorbidities at baseline and 3 months. Platform engagement was tracked during this period. We examined baseline differences between lonely and non-lonely participants; associations between loneliness, mental health symptoms, and comorbidities; and changes in loneliness and mental health through engagement in any form of care.

Results
At baseline, 57.8% of the sample were categorized as lonely. Loneliness was associated with younger age, fewer years of education, and the presence of a comorbidity (p values < .05). Baseline loneliness was associated with greater depression, anxiety, and stress and lower well-being and social support (ps < .001). The percentage of lonely participants decreased at follow-up (57.6% to 52.9%, p = .03). Those who improved in loneliness improved in mental health symptoms, well-being, and social support (ps < .001). Lonely participants who engaged in any form of care reported a greater reduction in loneliness than those who did not engage (p = .04).

Conclusions
This study confirms previous findings of the high prevalence of loneliness among adults and risk factors for increased loneliness. Findings highlight the potential of digital platforms to reach lonely individuals and alleviate loneliness through remote mental health support.
Long Period Grating Imprinted on a Flat-Shaped Plastic Optical Fiber for Refractive Index Sensing
Authors: Liu Yuan , Zhou Yanfei , Bao Haiyang , Zheng Jie 
Published: July 2023

AbstractA corrugated surface long period grating (LPG) was fabricated on a flat-shaped plastic optical fiber (POF) as a refractive index (RI) sensor by a simple pressing with the heat pressure and mechanical die press print method. The light propagation characteristics of an LPG imprinted on a multi-mode POF were analyzed by the method of geometrical optics. Theoretical and experimental results showed that the structural parameters of the sensor affected the RI sensing performance, and the sensor with a thinner flat thickness, a deeper groove depth of the corrugated surface LPG, and a longer LPG exhibited better RI sensing performance. When the POF with a diameter of 1 mm was pressed with the heat pressure to a flat shape with a thickness of 600 µm, an LPG with a period of 300 µm, a groove depth of 200 µm, and a length of 6 cm was fabricated on it, and the RI sensitivity of 1447%/RIU was obtained with a resolution of 5.494×10−6 RIU. In addition, the influences of the POF cladding, tilting of LPG, and bending of the sensing structure were investigated. The results demonstrated that after removing the cladding and tilting or bending the LPG, the RI sensing performance was improved. When the LPG imprinted on the flat-shaped POF was bent with a curvature radius of 6/π cm, the highest sensitivity of 6 563%/RIU was achieved with a resolution of 2.487×10−9 RIU in the RI range of 1.3330–1.4230. The proposed sensor is a low-cost solution for RI measurement with the features of easy fabrication, high sensitivity, and intensity modulation at the visible wavelengths.
Verso il pancreas artificiale: i sistemi ibridi ad ansa chiusa
Authors: Di Molfetta Sergio , de Candia Sara , Giorgino Francesco , Laviola Luigi 
Published: July 2023

SommarioDalle sue prime applicazioni agli inizi degli anni ’20, la terapia insulinica ha conosciuto avanzamenti tecnologici straordinari. L’integrazione fra monitoraggio in continuo del glucosio (CGM) e infusione sottocutanea continua di insulina (CSII) ha consentito la realizzazione di sistemi sempre più sofisticati che gestiscono in autonomia la somministrazione di insulina. Sebbene un pancreas artificiale completamente automatico non sia ancora disponibile per l’uso clinico, i dispositivi attualmente in commercio richiedono un intervento limitato da parte dell’utilizzatore e hanno dimostrato benefici su controllo glicemico, rischio d’ipoglicemia e qualità di vita. Un’adeguata formazione del team diabetologico e della persona con diabete resta comunque indispensabile per raggiungere e mantenere gli obiettivi di cura del diabete.
A Soft Robotic Fish Actuated by Artificial Muscle Modules (SoRoFAAM-1)
Authors: Tsimbo Fokou Moise Raphael , Xia Qirong , Jin Hu , Xu Min , Dong Erbao 
Published: July 2023

AbstractIn this paper, we present the design, fabrication, locomotion and bionic analysis of a Soft Robotic Fish Actuated by Artificial Muscle (SoRoFAAM). As a carangiform swimmer, the most important part of SoRoFAAM-1, on the motion point of view, is its tail designed around a bidirectional flexible bending actuator by layered bonding technology. This actuator is made of two artificial muscle modules based on Shape Memory Alloy (SMA) wires. Each artificial muscle module has four independent SMA-wire channels and is therefore capable of producing four different actuations. This design allows us to implement an adaptive regulated control strategy based on resistance feedback of the SMA wires to prevent them from overheating. To improve the actuation frequency to 2 Hz and the heat-dissipation ratio by 60%, we developed a round-robin heating strategy. Furthermore, the thermomechanical model of actuator is built, and the thermal transformation is analysed. The relationships between the actuation parameters and SoRoFAAM-1’s kinematic parameters are analysed. The versatility of the actuator endows SoRoFAAM-1 with cruise straight and turning abilities. Moreover, SoRoFAAM-1 has a good bionic fidelity; in particular, a maneuverability of 0.15, a head swing factor of 0.38 and a Strouhal number of 0.61.
A context-specific analysis of ethical principles relevant for AI-assisted decision-making in health care
Authors: Schlicht Larissa , Räker Miriam 
Published: July 2023

Abstract
Artificial intelligence (AI)-assisted technologies may exert a profound impact on social structures and practices in care contexts. Our study aimed to complement ethical principles considered relevant for the design of AI-assisted technology in health care with a context-specific conceptualization of the principles from the perspectives of individuals potentially affected by the implementation of AI technologies in nursing care. We conducted scenario-based semistructured interviews focusing on situations involving moral decision-making occurring in everyday nursing practice with nurses (N = 15) and care recipients (N = 13) working, respectively, living in long-term care facilities in Germany. First, we analyzed participants’ concepts of the ethical principles beneficence, respect for autonomy and justice. Second, we investigated participants’ expectations regarding the actualization of these concepts within the context of AI-assisted decision-making. The results underscore the importance of a context-specific conceptualization of ethical principles for overcoming epistemic uncertainty regarding the risks and opportunities associated with the (non)fulfillment of these ethical principles. Moreover, our findings provide indications regarding which concepts of the investigated ethical principles ought to receive extra attention when designing AI technologies to ensure that these technologies incorporate the moral interests of stakeholders in the care sector.
CACA guidelines for holistic integrative management of nasopharyngeal carcinoma
Authors: Tang Ling-Long , Chen Lin , Hu Chao-Su , Yi Jun-Lin , Li Jin-Gao , He Xia , Jin Feng , Zhu Xiao-Dong , Chen Xiao-Zhong , Sun Ying , Shen Liang-Fang , Yang Kun-Yu , Feng Mei , Hu Man , Xia Yun-Fei , Wang Ren-Sheng , Chen Chuan-Ben , Lu Tai-Xiang , Lin Shao-Jun , Lang Jin-Yi , Ma Jun 
Published: July 2023

Abstract
Purpose
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and is particularly prevalent in southern China. Unfortunately, international guidelines, such as NCCN or ESMO, fail to adequately coincide with clinical practice in China, making it difficult to achieve precision personalized therapy in China. The aim of this guideline is to better promote a “Multidisciplinary Team to Holistic Integrative Medicine" (MDT to HIM) system for the prevention, screening, diagnosis, treatment, and rehabilitation of NPC.

Methods
The China Anti-Cancer Association (CACA) invited domestic multi-disciplinary experts, involving radiologists, oncologists, surgeons, pathologists, herbalists, physiatrists, and psychologists, to write, discuss, and revise the guidelines. Based on the integration of research evidence, clinical experience, and patient needs, the domestic experts have iteratively developed these guidelines to provide proper and feasible management of NPC.

Results and conclusion
The CACA Guidelines for Holistic Integrative Management of Nasopharyngeal Carcinoma are more suitable for China's clinical practice, highlight Chinese characteristics, and have important clinical significance.
Mendelian Randomization Study of the Relationship Between Serum Matrix Metalloproteinases and the Occurrence of Sepsis
Authors: Yang Changzhen , Long Chun , Zhang Qianfu , He Dehua , Bi Hongying , Liu Xu 
Published: July 2023

Abstract
Background
Observational studies have shown that matrix metalloproteinases (MMPs) are associated with sepsis. However, it is unknown whether this association represents a causal relationship.

Methods
Mendelian randomization (MR) analysis was conducted to assess the potential causal role of circulating MMPs in sepsis. Single nucleotide polymorphisms (SNPs) associated with circulating MMPs levels were used as instrumental variables (IVs). In a sepsis genome-wide association study comprising 1573 cases and 454,775 European ancestry controls, we examined these IVs' effects using a two-sample MR study. Causal estimates were calculated using inverse variance weighting (IVW), the weighted median method, and MR-Egger analysis.

Results
Genetically predict that MMP-1 (OR = 1.011, 95% CI 0.772–1.325, p = 0.936), MMP-3 (OR = 1.036, 95% CI 0.862–1.244, p = 0.707), MMP-7 (OR = 1.206, 95% CI 0.960–1.515, p = 0.108), MMP-8 (OR = 1.041, 95% CI 0.949–1.144, p = 0.395), MMP-9 (OR = 1.101, 95% CI 0.831–1.458, p = 0.503), MMP-10 (OR = 1.028, 95% CI 0.840–1.260, p = 0.789) was not associated with the risk of sepsis.

Conclusions
The MR study does not provide evidence that circulating levels of MMPs (1, 3, 7, 8, 9, 10) were the causes of sepsis.
Cultivation of aromatic plant for nature-based sustainable solutions for the management of degraded/marginal lands: techno-economics and carbon dynamic
Authors: Yadav Deepika , Yadav Anisha , Singh Mayank , Khare Puja 
Published: July 2023

AbstractThe cultivation of aromatic grasses on marginal/degraded land attracts attention due to their remediation potential, low input cost, and economic gain. During the distillation of these aromatic grasses, a huge amount of solid and liquid waste (hydrosol) is generated, which is not only rich in carbon content but also has a good amount of nutrient. This review summarized the potential of aromatic plants for the restoration and vaporization of distilled waste into different value-added products. In this review, estimates of the economic cost and carbon dynamics for cultivation, distillation, and waste valorisation of aromatic grasses were made using available data. Based on the literature, the available degraded land reported for India (38,600 ha) was used for the calculation. The review discussed Scientometrics analysis, the remediation potential of aromatic plants, and various routes of valorization of distilled waste generated to achieve sustainable development goals. Scientometrics analysis demonstrated the studies that include the phytoremediation potential of aromatic grasses in recent years. Among the aromatic grasses, Chrysopogon zizaniodes (L.) Nash., Cymbopogon flexuosus and Cymbopogon martini were majorly used for reclamation purposes for dry land, mine-affected areas, and metal and pesticide-contaminated soils. The estimated profitability of the cultivation and carbon sequestration potential of these grasses in marginal/degraded land could be 22–629 million USD. Our estimations showed that the cost of carbon sequestration by the cultivation of the aromatic plant in degraded land could be 16–45 million USD. The conversion of distilled waste generated into compost, vermicompost, and biochar could sequester about 0.02 X105-335 X105 t of carbon (cost: 0.2–1913 million USD). The use of hydrosol and smoke water released during the process could sequester about 0.014 to 7403 t of carbon ( cost 0.001 to 0.42 million USD). Overall the review demonstrated the sustainability and carbon footprinting of the remediation process by aromatic grasses. The review allowed the exploration of knowledge-based strategies to unlock the potential of aromatic plants for restoration and carbon sequestration, along with the value addition of distilled waste in a sustainable manner. However, more databases are needed to support the information, which includes the productivity and selectivity of individual aromatic plant for different soil and agro-climatic regions.
Graphical Abstract
The Community Resiliency Model, an interoceptive awareness tool to support population mental wellness
Authors: Grabbe Linda , Duva Ingrid M. , Nicholson William C. 
Published: July 2023

AbstractThe objective of this article is to describe the Community Resiliency Model (CRM)®, a sensory-focused, self-care modality for mental well-being in diverse communities, and CRM’s emerging evidence base and neurobiological underpinnings as a task-sharing intervention. Frieden’s Health Impact Pyramid (HIP) is used as a lens for mental healthcare interventions and their public health impact, with CRM examples. CRM, a sensory awareness model for self-care and mental well-being in acute and chronic stress states, is supported by neurobiological theory and a growing evidence base. CRM can address mental wellness needs at multiple levels of the HIP and matches the task-sharing concept to increase access to mental health resources globally. CRM has the potential for making a significant population mental health impact as an easily disseminated, mental health, self-care modality; it may be taught by trained professionals, lay persons, and community members. CRM carries task-sharing to a new level: scalable and sustainable, those who learn CRM can share the wellness skills informally with persons in their social networks. CRM may alleviate mental distress and reduce stigma, as well as serve a preventive function for populations facing environmental, political, and social threats.
Intermittent Citizens: Scotland's Travellers, Welfare, and the Shifting Boundary of State and Voluntary Action in the Early Twentieth Century
Authors: Taylor Becky 
Published: July 2023

AbstractThis article explores the shifting relationship between Scottish Travellers, voluntary and mission action, and the state. Examining missionary and state attempts to settle, assimilate, and turn Scots Travellers into so-called good citizens in the first decades of the twentieth century—initially during the First World War and later in a designated camping scheme in Perthshire—reveals three things. First, many of the techniques used to manage Travellers’ behavior were not exceptional but rather can be seen as part of the wider armory deployed by welfare workers and reformers in this period. Often they used the particular sites of the mission hall, schoolroom, and camping ground to inculcate good citizenship. Second, the boundary between state and voluntary action was never fixed. And third, exploring how this boundary shifted over time can lead to a better understand of how Travellers were positioned as citizens at a time when both who was considered a citizen and what that might mean were profoundly changing. In this way, this article not only extends our understanding of Gypsy and Traveller history but also contributes to histories of the state, citizenship, and voluntary action.
A shallow approximation for ice streams sliding over strong beds
Authors: Warburton Katarzyna L. P. , Hewitt Duncan R. , Meyer Colin R. , Neufeld Jerome A. 
Published: July 2023

AbstractIce streams are regions of rapid ice sheet flow characterised by a high degree of sliding over a deforming bed. The shallow shelf approximation (SSA) provides a convenient way to obtain closed-form approximations of the velocity and flux in a rapidly sliding ice stream when the basal drag is much less than the driving stress. However, the validity of the SSA approximation breaks down when the magnitude of the basal drag increases. Here we find a more accurate expression for the velocity and flux in this transitional regime before vertical deformation fully dominates, in agreement with numerical results. The closed-form expressions we derive can be incorporated into wider modelling efforts to yield a better characterisation of ice stream dynamics, and inform the use of the SSA in large-scale simulations.
The Dynamics of Mass Mobilization in Belarus
Authors: Onuch Olga , Sasse Gwendolyn 
Published: July 2023

AbstractHow can and should we analyze mass mobilization and its outcomes in authoritarian (and potentially democratizing) states as social scientists? Are there any distinctive features to the study of mass mobilization and its outcomes in Eastern Europe? And how much should we focus on comparative analyses versus context and country specificities? The case of the 2020 mass mobilization in Belarus offers an opportunity to engage with and answer these questions in a reciprocal dialogue between scholars of protest and activism, politics of competitive authoritarian and democratizing contexts, and regional and country experts. This symposium brings together a diverse set of scholars and combines comparative and case-specific analyses and empirically driven and interpretive analyses that focus on different political, social, and cultural angles of this episode of mass mobilization and its aftermath.