bluuebunny/crossref_metadata_2025_split huggingface dataset:
First helminthological data on the Iberian adder, Vipera seoanei
Authors: Roca Vicente , Gómez-Ramírez Fernando , Espasandín Ismael , Megía-Palma Rodrigo , Perera Anna , Martínez-Freiría Fernando 
Published: January 2023

Abstract
Helminth fauna and some biotic and abiotic traits were analysed in Iberian adder Vipera seoanei (Squamata: Viperidae) a European viper nearly endemic to northern Iberian Peninsula, in an attempt to confirm previous claims of relationships between this ecological traits in this genus. A total of 317 samples mostly covering the distributional range of V. seoanei, were examined. Compared with other Vipera species from the Iberian Peninsula, the helminth fauna is also impoverished in V. seoanei, but it is contrary to other Vipera species from Central and East Europe. Helminths were mostly found in adult vipers, and occurred in vipers located at the periphery of the species range, characterised by low elevation, high temperature and precipitation levels, and abundant pastures.
Risk assessment method for emitter clogging in drip irrigation systems
Authors: dong aihong , Niu Wenquan , Zhang Wenqian , Lv Chang , wu menglong 
Published: January 2023

Abstract
Risk assessment of drip irrigation system emitter clogging is critical for the system's safe operation. In this paper, the emitter clogging risk and the calculation method are proposed based on risk theory and fuzzy comprehensive evaluation method to quantify the emitter clogging risk during drip irrigation system operation. Moreover, dynamic Bayesian network and emitter clogging degree monitoring data are combined to evaluate the drip irrigation system's emitter clogging risk. The relationship between drip flow channel structure, drip irrigation water quality, drip irrigation system operation, management mode, drip irrigation environment, and the emitter clogging risk of drip irrigation system is established. Based on the established relationship, the influence probability of different influencing factors on emitter clogging is obtained by expert experience and the Fuzzy membership function. Lastly, an emitter-clogging risk level table of the drip irrigation system is constructed. The results show that the model can better reflect the emitter clogging risk of the drip irrigation system and replace the occurrence probability of emitter clogging with fuzzy probability. In addition, the proposed model can quantitatively evaluate the probability of emitter clogging while risk factors can be identified, prevented, and controlled quickly and accurately. The sensitivity analysis shows that employing a fuzzy comprehensive evaluation method to calculate the probability of emitter clogging is reasonable and feasible. A risk level table can be employed to clarify the clogging risk status of the drip irrigation system, which can provide decision support and early warning treatment for drip irrigation system operation and management according to different clogging risk levels. Finally, corresponding anti-clogging measures can improve the system's life and operation efficiency.
Plasma acylcarnitines and amino acids in dyslipidemia: an integrated metabolomics and machine learning approach
Authors: Etemadi Ali , Mobaleghaleslam Houra , Mirabolghasemi Maryam , Ahmadi Mehdi , Dehghanbanadaki Hojat , Hosseinkhani Shaghayegh , Bandarian Fatemeh , Najjar Niloufar , Dilmaghani-Marand Arezou , Panahi Nekoo , Negahdari Babak , Mazloomi Mohammadali , Karimi-jafari Mohammad Hossein , Razi Farideh , Larijani Bagher 
Published: January 2023

Abstract

Background:‌ The Discovery of underlying intermediates associated with the development of dyslipidemia results in a better understanding of pathophysiology of dyslipidemia and their modification will be a promising preventive and therapeutic strategy for the management of dyslipidemia.
Methods: The entire dataset in this study was a large cross-sectional study that included 1200 subjects and was stratified into four binary classes with normal and abnormal cases based on their levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C.
The current study sought to first evaluate ​​plasma concentrations of 20 amino acids and 30 acylcarnitines in each class of dyslipidemia. Then, these attributes, along with baseline characteristics data, were used to check whether machine learning (ML) algorithms could classify cases and controls.
Results: Taking this into account, the levels of dyslipidemia classes fluctuate during the day, which produces data fluctuation, our ML framework accurately predicts TG binary classes. Moreover, the findings showed that alanine, phenylalanine, methionine, C3, C14:2, and C16 had great power in differentiating patients with high TG from normal TG controls.
Conclusions: The comprehensive output of this work, along with sex-specific attributes, will improve our understanding of the underlying intermediates involved in dyslipidemia.
Multi-Criteria Analysis of the Feasibility of E-Waste Pre-Treatment Scenarios: Case of a Brazilian City
Authors: Sales Ingrid Jale da Silva , Amorim Pedro Lopes Lucas , Souza Ricardo Gabbay 
Published: January 2023

Abstract

Waste electrical and electronic equipment (WEEE) have been largely generated in Brazil and worldwide. Besides the interest in recovering their valuable materials, some contain potentially hazardous components that must be removed and destined for treatment. WEEE pre-treatment is a critical step to efficiently sort and recover such components, but data availability is scarce in Brazil and developing countries, what may hinder feasibility analyses for its wider implementation. There is an increasing demand for studies that analyse the feasibility of WEEE reverse logistics systems, supporting their optimization. The present study analysed the feasibility of implementing WEEE pre-treatment units in a Brazilian municipality based on different levels of WEEE disassembly (A - basic; B - intermediate; and C - advanced) and implementation scenarios. Using the StEP tool and the multicriteria method ELECTRE TRI, the study classified implementation alternatives into three categories: more feasible; intermediate; and less feasible. The most feasible scenarios were related to an intermediate disassembly level (B). Alternatives with at least two pre-treatment units within the city were more feasible, even after some sensitivity analyses, indicating the advantages of smaller units and lower transport distances. This result may represent the reality of similar cities, both in Brazil and in developing countries.
Discrimination of the chemotherapy resistance status of human leukemia and glioblastoma cell lines by MALDI-TOF-MS profiling
Authors: Ledesma Martín , Poodts Daniela , Amoia Sofía , Hajos Silvia , Fundia Ariela , Vay Carlos , Pibuel Matías , Lompardía Silvina 
Published: January 2023

Abstract
Chemotherapy mistreatment is partially due to a lack of rapid and reliable tools to discriminate between sensitive and resistant phenotypes. In many cases, the resistance mechanism is not fully understood, impacting diagnostic tools' absence. This work aims to determine the capacity of MALDI-TOF-MS profiling to discriminate between chemotherapy-resistant and sensitive phenotypes in leukemia and glioblastoma cells. A multivariate analysis of two therapy-resistant leukemia cell lines (Ki562 and Kv562) and two TMZ-resistant glioblastoma cell lines (U251R and LN229R) and their sensitive counterparts was performed. In this work, we first show MALDI-TOF-MS patterns analysis's ability to differentiate these cancer cell lines by their chemotherapy-resistant status. We present a rapid and inexpensive tool that would guide and complement the therapeutic decision.
Phase I, first-in-human study of XTR004, a novel 18F-labeled tracer for myocardial perfusion PET: biodistribution, radiation dosimetry, pharmacokinetics and safety after a single injection at rest
Authors: Ren Chao , Pan Qingqing , Fu Chao , Wang Peipei , Zheng Zhiquan , Hsu Bailing , Huo Li 
Published: January 2023

Abstract
Purpose: XTR004 is a novel 18F-labeled myocardial perfusion imaging tracer that can be clinically used to assess myocardial ischemia from coronary artery disease. This study aimed to evaluate imaging characteristics of XTR004 after a single injection at rest in humans.
Methods: Eleven healthy subjects (man=8) received an intravenous injection of 239-290 MBq (6.5-7.8 mCi) XTR004 and imaged with nine whole-body positron emission tomography (PET) scans within 4.7 h. Collection of blood and urine samples was concurrently performed for 7.25 h. Image processing utilized 3D registered PET and CT images to derive %ID and then calculated the radiation dose using a Hermes workstation with the embedded OLINDA/EXM program. The radioactive count profile was measured for whole-blood, plasma, and urine to characterize pharmacokinetics with the metabolic correction. The safety profile was evaluated during the day of dosing and three follow-up visits, including physical examination, vital signs, laboratory tests and adverse event observation.
Results: Myocardial uptake of XTR004 was rapid, high, and stable throughout the PET imaging period. In the 0-12 min PET images, the top five organs of %ID were liver (26.81±4.01), kidney (11.43±2.49), lung (6.75±1.76), myocardium (4.72±0.67) and spleen (3.1±0.84). Mean values of Cmax, Tmax, t1/2, and AUC0-last calculated by the non-compartment model in corrected plasma were 0.0013896 %ID/g, 2.543 min, 45.171 min, and 0.03314 min* (%ID/g), respectively. Whole-body effective dose per unit of injected activity was 0.0165 mSv/MBq. Cumulative urine excretion (Cum Ae) was 8.18%. Treatment‐related adverse events occurred in seven subjects (63.6%) and were overall reported as stimulated pain at the injection site. No severe adverse event was collected.
Conclusions: XTR004 having a favorable safety profile with rapid, high, and stable myocardial uptake in humans demonstrated an excellent potential for PET MPI. Further exploration of XTR004 PET MPI to detect myocardial ischemia can be warranted. (A Study of XTR004 PET Radiotracer in Healthy Volunteers, ClinicalTrials.gov number NCT05195879.)
Predicting union, osteomyelitis, and amputation outcomes of open type IIIC tibial fractures: A retrospective study
Authors: Chen Shih-Heng , Lien Po-Hao , Lan Ching-Yu , Hsu Chung-Cheng , Lin Cheng-Hung , Lin Yu-Te , Lin Chih-Hung , Yu Yi-Hsun 
Published: January 2023

Abstract
Background: We aimed to assess the factors that affect union time and complications in IIIC (based on the Gustilo classification) tibial fractures.
Materials and Methods: This retrospective analysis included patients with IIIC open tibial fractures during a 20-year period. All the medical records were reviewed, and the outcomes were investigated.
Results: Fifty-eight patients were enrolled and grouped by union time: on-time (eight), late (27), delayed (eight), non-union, and amputation required (12). Nine fractures were complicated by osteomyelitis. Union time was significantly prolonged in cases of triple arterial injury, distal third fractures, an Injury Severity Score (ISS) ≥ 16, and/or increased length of bone defect. A bone gap > 50 mm, diabetes mellitus, low body mass index, or triple arterial injury were significant risk factors for amputation. Time from injury to definitive soft tissue coverage was a major risk factor for osteomyelitis if it exceeded 22 days. Predicted probability of union within 2 years was stratified based on a generated scoring system.
Conclusions: An effective system predicting union time was built based on the selected factors. Early soft tissue coverage reduces the risk of osteomyelitis, while diabetes and severe bone and soft tissue defects increase the risk of amputation.
Trial registration: not applicable
Level of evidence: IV
Cytological and genetic effects of rye chromosomes 1RS and 3R on the wheat-breeding founder parent Chuanmai 42 from southwestern China
Authors: Wan Hongshen , Yang Manyu , Li Jun , Wang Qin , Liu Zehou , Zheng Jianmin , Li Shizhao , Yang Ning , Yang Wuyun 
Published: January 2023

Abstract
Rye (Secale cereale L.) is an important genetic resource for improving the disease resistance of wheat. An increasing number of rye chromosome segments have been transferred into modern wheat cultivars via chromatin insertions. In this study, 185 recombinant inbred lines (RILs) derived from a cross between a common wheat accession containing rye chromosomes 1RS and 3R and a wheat-breeding founder parent (Chuanmai 42) from southwestern China were used to decipher the cytological and genetic effects of 1RS and 3R via fluorescence/genomic in situ hybridization and quantitative trait locus (QTL) analyses. Chromosome breakage was detected in the RIL population. Additionally, the recombination of chromosomes 1BS and 3D from Chuanmai 42 was completely suppressed by 1RS and 3R in the RIL population. In contrast to chromosome 3D of Chuanmai 42, rye chromosome 3R was significantly associated with white seed coats and decreased yield-related traits, as revealed by QTL and single marker analyses, whereas it had no effect on stripe rust resistance. Rye chromosome 1RS did not affect yield-related traits and it increased the susceptibility of plants to stripe rust. Most of the detected QTLs that positively affected yield-related traits were from Chuanmai 42. The findings of this study suggest that the negative effects of rye-wheat substitutions or translocations, including the suppression of the pyramiding of favorable QTLs on paired wheat chromosomes from different parents and the transfer of disadvantageous alleles to filial generations, should be considered when selecting germplasm to enhance wheat-breeding founder parents or to breed new varieties.
Soil Loss and Reservoir sedimentation assessment of Kaddam watershed using Geographical Information systems and Remote sensing Techniques
Authors: Kodimela Anil , S Sivaprakasam , Srid Parupally 
Published: January 2023

Abstract
Soil loss is a significant threat in both onsite and offsite issues of worldwide, and more attention is required to compensate for the soil loss, loss of fertility, nutrients, valuable minerals, and silt deposition in reservoirs. The geographical distribution of soil loss was evaluated using the Universal Soil Loss Equation (USLE) model, and the Kaddam watershed's reservoir sedimentation was calculated using a trapezoidal equation. Rainfall erosivity (R- factor) minimum and maximum values in Kaddam and Indervally rain gauge stations were 416.25 and 492.93 MJ.mm/ha.h.yr. Soil erodability factor (K-Factor) is 0.3 t ha h/ha/mj/mm for clayey soils, and slope length found as up to 380 (dimension less) and crop and management factors considered on local crops and agricultural practices in Kaddam watershed. According to the USLE equation, the maximum spatial distribution of soil depletion is 60 tonnes/hectare/year, whereas the sediment yield assessment through the reservoir is 57 t/ha/year. Many researchers used methods to assess the soil loss or yield separately but not integrated in single environment. To fulfil the gap, chosen Kaddam watershed, computed two methods separately and simulations compared with observed hydrographic survey shown satisfactorily. Hence, predication and method of the present study can adopt other reservoirs.
The Sleeping Brain’s Connectivity and Family Environment: Characterizing Sleep EEG Coherence in an Infant Cohort
Authors: Markovic Andjela , Schoch Sarah F. , Huber Reto , Kohler Malcolm , Kurth Salome 
Published: January 2023

Abstract

Brain connectivity closely reflects brain function and behavior. Sleep EEG coherence, a measure of brain’s connectivity during sleep, undergoes pronounced changes across development under the influence of environmental factors. Yet, the determinants of the developing brain’s sleep EEG coherence from the child’s family environment remain unknown. After characterizing high-density sleep EEG coherence in 31 healthy 6-month-old infants by detecting strongly synchronized clusters through a data-driven approach, we examined the association of sleep EEG coherence from these clusters with factors from the infant’s family environment. Clusters with greatest coherence were observed over the frontal lobe. Higher delta coherence over the left frontal cortex was found in infants sleeping in their parents’ room, while infants sleeping in a room shared with their sibling(s) showed greater delta coherence over the central parts of the frontal cortex, suggesting a link between local brain connectivity and co-sleeping. Finally, lower occipital delta coherence was associated with maternal anxiety regarding their infant’s sleep. These interesting links between sleep EEG coherence and family factors have the potential to serve in early health interventions as a new set of targets from the child’s immediate environment.
Effectiveness assessment of paraloid B-72 enhanced with Nano materials to improve of mortars properties for conservation of Seti I temple in Al-Qurna, Thebes west bank, Egypt
Authors: H.Mohamed Essam 
Published: January 2023

Abstract
This paper presents an experimental study to assessment of the potential effectiveness of four consolidation treatments performed with: Nano silica 5% dissolved in water, Nano lime 5% dissolved in ethanol, Paraloid B72 3% dissolved in toluene enhanced with Nano silica 5%, and Paraloid B72 3% dissolved in toluene enhanced with Nano lime 5% to improve the physical and mechanical properties of proposed completion mortars that will use to compensation of the missing parts of the sandstone. The experimental samples were exposed to artificial ageing cycles and investigated by several scientific techniques such as; X-Ray Diffraction (XRD), Polarized light microscope (PLM), Scanning Electron Microscopy (SEM) coupled with X-ray energy dispersive system (EDS), and the physical and mechanical properties tests to determine the appropriate mortar for the completion process. Results of this study indicated that the mortar which consolidated by 3% of paraloid B72 enhanced with 5% of Nano silica and 3% of paraloid B72 enhanced with 5% of Nano lime achieved the best results.
Relationship between anemia and learning performance in Chinese primary school students: evidence from a large national survey
Authors: hu yisong , Wang Weidong 
Published: January 2023

Abstract
This study explored the association between anemia and learning performance, and the possible factors mediating this association among Chinese adolescents. Data of 17695 Grade 4 students from China Education Panel Survey were analyzed. Anemia was diagnosed according to the World Health Organization’s reference. Test scores for Chinese, mathematics and English were gathered from the final examination of previous semester. An ordinary least squares regression and mediation effect analysis were conducted. Our findings found the prevalence of anemia was 6.52% among Chinese Grade 4 students. Students without anemia had a higher average test score for three academic subjects than students with anemia (P = 0.000); their test scores for Chinese, mathematics, and English were also higher (P < 0.05). Multivariate regression analysis showed a negative association between anemia and average test scores as well as individual test scores for the three subjects. Mediation analysis found that anemia affected learning performance directly (P < 0.05), and indirectly by decreasing the cognition score (P < 0.05). The indirect effect was 19.9% of the total effect. Findings highlighted anemia affected learning performance both directly and indirectly. Nutrition-related interventions should be implemented to prevent a decrease in learning performance among students with anemia.
Probiotics and Prebiotics in Subclinical Hypothyroidism of pregnancy with Small Intestinal Bacterial Overgrowth
Authors: Ouyang Qian , Xu Yajuan , Ban Yanjie , Li Jingjing , Cai Yanjun , Wu Bo , Hao Yingqi , Sun Zongzong , Zhang Miao , Wang Mengqi , Wang Wentao , Zhao Yinkai 
Published: January 2023

Abstract
Objective: Evaluating efficacy of probiotics combined with prebiotics in small intestinal bacterial overgrowth (SIBO) in subclinical hypothyroidism (SCH) in the second trimester.
Methods: We collected data from 78 pregnant women with SCH(SCH group)and 74 normal pregnant women(Control group) in second trimester，compare the differences in high sensitivity C-reactive protein (hsCRP), result of lactulose methane-hydrogen breath test and gastrointestinal symptoms assessed by GSRS scale between two groups.In SCH group, 32 patients with SIBO were selected as Intervention group. Treatment with probiotics + prebiotics for 21 days; The differences of lipid metabolism, hsCRP, thyroid function level, methane-hydrogen breath test results and GSRS scores before and after treatment were compared to evaluate the therapeutic effect.
Results: 1. The positive rate of SIBO and methane，hsCRP levels in SCH group were higher than those in control group(P <0.05),the total score of GSRS scale, mean score of indigestion and constipation syndrome in SCH group were higher (P <0.05).2. The mean abundance of hydrogen and methane were higher in SCH group 3.After treatment, serum levels of thyrotropin (TSH), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and hsCRP in intervention group were decreased , and high-density lipoprotein (HDL) was increased compared with before treatment (P<0.05).4.After treatment, Methane positive rate, total score of GSRS scale, mean score of diarrhea syndrome, dyspepsia syndrome and constipation syndrome were decreased. (P < 0.05)5. The average abundance of methane and hydrogen were lower.
Conclusion: Probiotics combined with prebiotics are effective in the treatment of SIBO in pregnant SCH patients .
Clinical Trial Registration Number: ChiCTR1900026326