bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Roux-en-Y Gastric Bypass with the novel robotic platform HUGO™ RAS
Authors: Raffaelli Marco , Voloudakis Nikolaos , Pennestrì Francesco , Gallucci Pierpaolo , Modesti Cristina , Salvi Giulia , Greco Francesco , Ciccoritti Luigi 
Published: June 2023

IntroductionRobotic assisted surgery is a rapidly developing field of minimally invasive bariatric surgery in the last 20 years. Its wide diffusion has led to the development and standardization of robotic assisted approaches for bariatric operations. In this study, we present the first four Roux-en-Y Gastric Bypass (RYGB) operations performed with the new Hugo™ RAS system (Medtronic, Minneapolis, MN, USA).MethodsIn January and February 2023, 4 consecutive patients scheduled for minimal invasive Roux-en-Y-Bypass were selected and underwent the procedure robotic-assisted with the new platform. No exclusion criteria were applied.ResultsFour patients, two females and two males, underwent RYGB with a median BMI of 40 Kg/m2 (range: 36–46) and diabetes mellitus in two cases. The median docking time was 8 min (range: 7–8.5) and the median console time was 127.5 min (range: 95–150). A description of the operating theatre, robotic arms and docking setup is provided. Procedures were performed without intraoperative complications and no conversion to laparoscopy or open surgery was noted. No additional ports were needed to be placed. System's function and docking were uneventful. No early post-operative complications were observed.ConclusionsBased on our initial experience, RYGB with the Hugo™ RAS system is feasible. This study provides the configurations necessary to perform RYGB with the Hugo™ RAS system as well as general information and insights from our preliminary experience.
Grimace scale assessment during Citrobacter rodentium inflammation and colitis development in laboratory mice
Authors: Peppermüller Pia Pascale , Gehring Jonathan , Zentrich Eva , Bleich André , Häger Christine , Buettner Manuela 
Published: June 2023

IntroductionBacterial infections and chronic intestinal inflammations triggered by genetic susceptibility, environment or an imbalance in the intestinal microbiome are usually long-lasting and painful diseases in which the development and maintenance of these various intestinal inflammations is not yet fully understood, research is still needed. This still requires the use of animal models and is subject to the refinement principle of the 3Rs, to minimize suffering or pain perceived by the animals. With regard to this, the present study aimed at the recognition of pain using the mouse grimace scale (MGS) during chronic intestinal colitis due to dextran sodium sulfate (DSS) treatment or after infection with Citrobacter rodentium.MethodsIn this study 56 animals were included which were divided into 2 experimental groups: 1. chronic intestinal inflammation (n = 9) and 2. acute intestinal inflammation (with (n = 23) and without (n = 24) C. rodentium infection). Before the induction of intestinal inflammation in one of the animal models, mice underwent an abdominal surgery and the live MGS from the cage side and a clinical score were assessed before (bsl) and after 2, 4, 6, 8, 24, and 48 hours.ResultsThe highest clinical score as well as the highest live MGS was detected 2 hours after surgery and almost no sign of pain or severity were detected after 24 and 48 hours. Eight weeks after abdominal surgery B6-Il4/Il10-/- mice were treated with DSS to trigger chronic intestinal colitis. During the acute phase as well as the chronic phase of the experiment, the live MGS and a clinical score were evaluated. The clinical score increased after DSS administration due to weight loss of the animals but no change of the live MGS was observed. In the second C57BL/6J mouse model, after infection with C. rodentium the clinical score increased but again, no increased score values in the live MGS was detectable.DiscussionIn conclusion, the live MGS detected post-operative pain, but indicated no pain during DSS-induced colitis or C. rodentium infection. In contrast, clinical scoring and here especially the weight loss revealed a decreased wellbeing due to surgery and intestinal inflammation.
Molecular Survey and Genetic Characteristics of Vector-Borne Pathogens in Domestic Dogs from Four Regions of China
Authors: Yin Fangyuan , Guo Chuanjiang , Li Dong , Tian Zhuojia , Li Facai 
Published: June 2023

Canine vector-borne diseases are widely distributed around the world. They are transmitted by arthropods, and many seriously threaten the health of animals and humans. In China, our knowledge of Ehrlichia, Hepatozoon, and Mycoplasma species circulating in dogs is still poorly understood. Therefore, the aim of this study was to understand the prevalence and genetic characteristics of canine Ehrlichia spp., Hepatozoon spp., and Mycoplasma spp. in Chongqing (southwest), Fujian (southeast), Shandong (southeast), and Hubei (central) Provinces of China. Blood samples from healthy pet dogs were processed to detect Ehrlichia, Hepatozoon, and Mycoplasma DNA with PCR. Haplotype and phylogenetic analyses were performed on 18S rRNA sequences. Among 306 dogs, no Ehrlichia spp. or Mycoplasma spp. were detected, whereas one Hepatozoon sp. was detected in 10 (3.27%) of the animals. Only Hepatozoon canis was identified and was endemic to Chongqing (2.46%) and Hubei (8.77%). A haplotype analysis identified eight haplotypes among the H. canis isolates. A phylogenetic analysis showed that the H. canis isolates in this study clustered into four clades, together with isolates from different countries and hosts, forming a large group that was clearly separate from other Hepatozoon species. These findings provided new information on the epidemiological characteristics of canine vector-borne diseases in China and will be helpful in the development of efficient measures to safeguard the health and well-being of companion animals and their owners.
BRAF V600E Mutation of Non-Small Cell Lung Cancer in Korean Patients
Authors: Ahn Hyo Yeong , Lee Chang Hun , Lee Min Ki , Eom Jung Seop , Jeong Yeon Joo , Kim Yeong Dae , Cho Jeong Su , Lee Jonggeun , Lee So Jeong , Shin Dong Hoon , Kim Ahrong 
Published: June 2023

Background and Objectives: BRAF mutational status in resected non-small cell lung cancer (NSCLC) in the Korean population is poorly understood. We explored BRAF (particularly BRAF V600E) mutational status among Korean patients with NSCLC. Materials and Methods: This study included 378 patients with resected primary NSCLC who were enrolled from January 2015 to December 2017. The authors obtained formalin-fixed paraffin-embedded (FFPE) tissue blocks and performed peptide nucleic acid (PNA)-clamping polymerase chain reaction (PCR) for detecting BRAF V600, real-time PCR for detecting BRAF V600E, and immunohistochemical analyses using the mutation-specific Ventana VE1 monoclonal antibody. For positive cases in any methods mentioned above, direct Sanger sequencing was additionally performed. Results: The PNA-clamping method revealed the BRAF V600 mutation in 5 (1.3%) of the 378 patients. Among these five patients, real-time PCR, direct Sanger sequencing detected BRAF V600E mutations in three (0.8%) patients. Thus, two cases showed differences in their PNA-clamping and the others. Direct Sanger sequencing of PNA-clamping PCR product was performed for two cases showing negative results on direct Sanger sequencing; both contained BRAF mutations other than V600E. All patients harboring BRAF mutations had adenocarcinomas, and all patients with V600E mutation exhibited minor micropapillary components. Conclusions: Despite the low incidence of the BRAF mutation among Korean patients with NSCLC, lung adenocarcinoma patients with micropapillary components should be prioritized in terms of BRAF mutation testing. Immunohistochemical staining using Ventana VE1 antibody may serve as a screening examination for BRAF V600E.
Electronic safety-netting tool features considered important by UK general practice staff: an interview and Delphi consensus study
Authors: Friedemann Smith Claire , Duncombe Sue , Fleming Susannah , Hirst Yasemin , Black Georgia Bell , Bankhead Clare , Nicholson Brian D 
Published: June 2023

BackgroundThe potential of the electronic health record to support safety netting has been recognised and a number of electronic safety-netting (E-SN) tools developed.AimTo establish the most important features of E-SN tools.Design & settingUser-experience interviews followed by a Delphi study in a primary care setting in the UK.MethodThe user-experience interviews were carried out remotely with primary care staff who had trialled the EMIS E-SN toolkit for suspected cancer. An electronic modified Delphi approach was used, with primary care staff involved in safety netting in any capacity, to measure consensus on tool features.ResultsThirteen user-experience interviews were carried out and features of E-SN tools seen as important formed the majority of the features included in the Delphi study. Three rounds of Delphi survey were administered. Sixteen responders (64%) completed all three rounds, and 28 out of 44 (64%) features reached consensus. Primary care staff preferred tools that were general in scope.ConclusionPrimary care staff indicated that tools that were not specific to cancer or any other disease, and had features that promoted their flexible, efficient, and integrated use, were important. However, when the important features were discussed with the patient and public involvement (PPI) group, they expressed disappointment that features they believed would make E-SN tools robust and provide a safety net that is difficult to fall through did not reach consensus. The successful adoption of E-SN tools will rely on an evidence base of their effectiveness. Efforts should be made to assess the impact of these tools on patient outcomes.
Ideas, concerns, expectations, and effects on life (ICEE) in GP consultations: an observational study using video-recorded UK consultations
Authors: Edwards Peter J , Sellers Grace M , Leach Isabel , Holt Lydia , Ridd Matthew J , Payne Rupert A , Barnes Rebecca K 
Published: June 2023

BackgroundEliciting patients’ ideas, concerns, expectations, and whether a problem has an 'effect' on their life (ICEE), is a widely recommended communication technique. However, it is not known how frequently ICEE components are raised in UK GP consultations.AimTo assess the frequency of ICEE in routine GP consultations with adult patients and explore variables associated with ICEE.Design & settingAn observational study was undertaken. It involved secondary analysis of a pre-existing archive of video-recorded, face-to-face GP consultations in the UK.MethodObservational coding of 92 consultations took place. Associations were assessed using binomial and ordered logistic regression.ResultsMost consultations included at least one ICEE component (90.2%). The most common ICEE component per consultation was patient ideas (79.3%), followed by concerns (55.4%), expectations (51.1%), and then effects on life (42.4%). For all ICEE components patients more commonly initiated the ICEE dialogue, and in only three consultations (3.3%) did GPs directly ask patients about their expectations. Problems that were acute (odds ratio [OR] 2.98, 95% confidence interval [CI] = 1.36 to 6.53,P= 0.007) or assessed by GPs aged ≥50 years (OR 2.10, 95% CI = 1.07 to 4.13,P= 0.030) were associated with more ICEE components. Problems assessed later in the consultation (OR 0.60 per problem order increase, 95% CI = 0.41 to 0.87,P= 0.007) by patients aged ≥75 years (OR 0.40, 95% CI = 0.16 to 0.98,P= 0.046) and from the most deprived cohort (OR 0.39, 95% CI = 0.17 to 0.92,P= 0.032) were associated with fewer ICEE components. Patient ideas were associated with more patients being ‘very satisfied’ post-consultation (OR 10.74, 95% CI = 1.60 to 72.0,P= 0.014) and the opposite was true of concerns (OR 0.14, 95% CI = 0.02 to 0.86,P= 0.034).ConclusionICEE components were associated with patient satisfaction and demographic variables. Further research is required to assess if the way ICEE are communicated affects these associations and other potential confounders.
Propiedades psicométricas de un instrumento para el aprovechamiento académico en función del uso de dispositivos móviles (teléfonos inteligentes)
Authors: Mena Rodríguez Helin Yadira , Garrido Bermúdez Emerson 
Published: June 2023

El objetivo de esta investigación es proponer un instrumento que mida el aprovechamiento académico de los dispositivos móviles en estudiantes de 10º y 11º de la Institución Educativa Barrio Olaya Herrera (IEBOH) de la ciudad de Medellín Colombia. El estudio fue realizado a través de un cuestionario en línea a 293 estudiantes, divididos en dos grupos, 168 estudiantes para realizar el análisis factorial exploratorio (AFE) y 125 para el análisis factorial confirmatorio (AFC) mediante el formulario en Google form.
Cuenta con un diseño cuantitativo no experimental transversal, un alcance de tipo correlacional causal y explicativo, enmarcado en un muestreo no probabilístico.
En cuanto a los resultados se obtuvieron valores satisfactorios, en el AFE un KMO y una prueba de esfericidad de Bartlett ( ) significativa, , para el AFC de . Con relación al análisis de la consistencia interna del instrumento, para medir su confiabilidad, se obtuvo a través del programa JAMOVI, el cual de modo general arrojó un coeficiente de correlación de Alfa Cronbach ( ) y un omega de McDonald’s ( ) que explica el de la varianza total y las propiedades psicométricas requeridas para ser validado. La validez convergente arrojó derivaciones significativas. Pudiéndose concluir sobre la importancia de los dispositivos móviles como herramienta de apoyo en las actividades escolares como también en el desarrollo de competencias dentro de las dinámicas de la clase orientada.
PENGARUH KEKUATAN OTOT LENGAN, DAYA LEDAK OTOT TUNGKAI, DAN MOTIVASI BERPRESTASI TERHADAP PRESTASI LAN RENANG GAYA DADA RINJANI CLUB
Authors: Maulidin  , Anwar Zul 
Published: June 2023

Tujuan dari penelitian ini adalah untuk mendapatkan informasi tentang efek langsung kekuatan otot lengan, daya ledak otot tungkai, dan motivasi berprestasi terhadap kecepatan renang 25 meter gaya dada. Sampel penelitian seluruh anggota club renang Rinjani (KU I dan KU II) sebanyak 32 orang yang berpartisipasi dalam penelitian ini. tes kecepatan renang gaya dada adalah dengan menggunakan tes renang gaya dada jarak 25 m dengan tetap mempertahankan gaya renangan yang benar yang ditinjau dari sikap posisi tubuh, gerakan tungkai, gerakan lengan, gerakan mengambil nafas serta koordinasi gerakan, Kekuatan Otot Lengan dengan menggunakan tes dynamometer, Daya Ledak Otot Tungkai menggunakan Vertical Jump, Motivasi Berprestasi menggunakan angket. Hasil penelitian menyimpulkan: kekuatan otot lengan berpengaruh langsung positif dimana (R² = 0,657), daya ledak otot tungkai berpengaruh langsung positif dimana (R² = 0,989), motivasi berpengaruh langsung positif dimana (R² = 0,993)), kekuatan otot lengan berpengaruh langsung positif terhadap motivasi berprestasi dimana (0,643), daya ledak otot tungkai berpengaruh langsung positif terhadap motivasi berprestasi dimana (0,984), Secara keseluruhan, dapat disimpulkan bahwa setelah analisis statistik data empiris diperoleh dari lapangan, dapat dikatakan bahwa variabel independen memiliki pengaruh langsung positif signifikan terhadap kecepatan renang dengan daya ledak otot tungkai yang memiliki pengaruh lebih besar yaitu 0,989 atau 98,9% kecepatan pada renang gaya dada. Daya ledak otot tungkai merupakan prediktor tunggal terbaik dari kecepatan renang pada atlet club Rinjani. Untuk memperhitungkan hasil ini, sangat penting untuk mempertimbangkan parameter teknik stroke spesifik ketika memprediksi keberhasilan pada perenang muda
THE RELATIONSHIP AMONG KNOWLEDGE, ATTITUDE, AND BEHAVIOR OF DIETARY, AND THE INCIDENCE OF ANEMIA ON ADOLESCENT GIRLS
Authors: Subagja Citra Algiatie , Fatmawati Ariani , Gartika Nina 
Published: June 2023

Anemia in adolescent girls is quite high. According to the World Health Organization (WHO), the prevalence of anemia in adolescent girls around 53,7%. The impact of anemia on adolescent girls is drowsy, lack of concentration, lethargic, and dizziness in the learning time. This study aimed to determine the relationship of dietary knowledge, attitudes, and behavior level and the incidence of anemia on adolescent girls in Kemala Bhayangkari Junior High School. The study design used quantitative analytic with a cross-sectional design. The sample was taken by the consecutive sampling method. The samples were 134 respondents. Data analysis used the Spearman rank correlation test .The results showed that adequate dietary knowledge (48.5%), positive dietary attitude (59.7%), positive dietary behavior (56.0%), and anemia (18.7%) with a value for knowledge p = 0.803, attitude p = 0.973 and behavior p = 0.997. It can be concluded that there is no relationship among of dietary knowledge, attitudes, and behavior level and the incidence of anemia on adolescent girls with anemia in Kemala Bhayangkari Junior High School Bandung. It is suggested for adolescent girls that they needs to increase the consumption of nutritious foods, foods with high in iron, and consume iron supplements, especially during menstruation.
PENGARUH SARI KACANG HIJAU (VIGNA RADIATA) TERHADAP KADAR HEMOGLOBIN ANAK USIA SEKOLAH DENGAN ANEMIA DEFISIENSI ZAT BESI
Authors: Santoso Mochamad Budi , Mulyati Rini , Rukmana Avisya Fadila 
Published: June 2023

Anemia defisiensi zat besi merupakan salah satu masalah gizi yang utama di Indonesia. Prevalensi anemia defisiensi zat besi di Indonesia berdasarkan karakteristik usia untuk anak usia sekolah (5-14 tahun) mencapai 26,4%, sedangkan di Cimahi, prevalensi anemia defisisnesi zat besi pada anak usia sekolah mencapai 7%. Anak usia sekolah memiliki pola makan yang cenderung tidak teratur, selera makan yang tidak menentu, dan kesukaran untuk makan makanan bergizi. Hal ini mengakibatkan anak sangat rentan mengalami anemia defisiensi zat besi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian sari kacang hijau (Vigna radiata) terhadap kadar Hemoglobin anak usia sekolah dengan anemia defisiensi zat besi. Penelitian ini menggunakan desain “Praeksperiment” dengan rancangan “One group pretest posttest”. Jumlah sampel sebanyak 15 orang yang diambil menggunakan teknik total sampling. Analisa data yang digunakan adalah analisa univariat dan analisa bivariat dengan uji Paired T-test (t-test dependent). Hasil penelitian menunjukan bahwa rerata kadar hemoglobin anak usia sekolah sebelum diberikan sari kacang hijau adalah 11,4, dan rerata setelah pemberian sari kacang hijau adalah 13,3. Hasil statistik diperoleh p value (0,001) < α (0,05), sehingga dapat disimpulkan bahwa sari kacang hijau efektif untuk meningkatkan kadar Hemoglobin anak usia sekolah dengan anemia defisiensi zat besi. Sari kacang hijau dapat dijadikan salah satu intervensi keperawatan dalam meningkatkan kadar hemoglobin anak usia sekolah dengan anemia defisiensi zat besi.
RELATIONSHIP OF SELF-ESTEEM TO POSTPARTUM DEPRESSION IN POSTPARTUM MOTHERS
Authors: Wardani Vina Ayu , Lestari Kustati Budi , Nurbaeti Irma 
Published: June 2023

Self-esteem influences women's transition to a new identity and adjustment of motherhood. Mothers with low self-esteem have poor coping, so it is easy to experience depression. In the postpartum period, physiological changes and psychological changes can trigger anxiety and depression that affect the bonding of the baby and mother. The purpose of this study was to find out if there was a link between self-esteem and postpartum depression. Method Quantitative research with cross-sectional design against 287 postpartum mothers 1-12 months meets inclusion criteria. Collection of research data in March – June 2016 in the working area of Puskesmas Ciputat Timur and Ciputat Tangerang Selatan; and Kebayoran Lama and Cilandak Jakarta Selatan. The research instrument uses the Indonesian version of the Edinburgh postpartum depression scale to measure postpartum depression and Rosenberg Self-Esteem Scale in Bahasa Indonesia to measure postpartum maternal self-esteem. Data collection with home visits. Test the statistic using Chi-square with α=0.05. The results showed that of the 38% of mothers with low self-esteem, 11.5% had postpartum depression. The chi-square test analysis results have a relationship between self-esteem and postpartum depression (p=0.002 value). Conclusion mothers with low self-esteem are at higher risk of causing postpartum depression, so it is necessary to increase postpartum mothers' self-esteem to undergo a transition period happily.
MANAGEMENT OF PREECLAMPSIA IN PREGNANT WOMEN : LITERATURE REVIEW
Authors: Sukmawati Sukmawati , Mamuroh Lilis , Nurhakim Furkon , Hermayanti Yanti 
Published: June 2023

Preeclampsia is a direct cause of maternal death in addition to bleeding and infection. Preeclampsia also causes stunted fetal growth so that it is at risk of threatening the safety of the fetus. Management of preeclampsia is one of the efforts to reduce maternal and infant mortality. This literature review aims to analyze the management of preeclampsia in pregnant women. The database used is Google Scholar, Science Direct and PubMed with keywords preeclampsia or preeclampsia, pregnant women or pregnant women, management or implementations.The article search results were obtained from Science Direct 124 articles, Google Scholar 1076 and PubMed 252 articles, after screeningobtained from Science Direct 4 articles were, Google Scholar 28 and PubMed 10 articles. The inclusion criteria used werearticles full text, using adesign randomized controlled trial, experimental and quasi-experimental, using Indonesian and English, published in 2015-2020, a sample of preeclamptic pregnant women and the focus of the nursing intervention literature. There were 9 articles that met the requirements. The results of the analysis showed that the management of preeclampsia includes physical stretching exercises, stretching exercises versus autogenic training, listening to Ar-Rahman's murottal letter, Stimulus Cutaneous Slow Stroke Back Massage, psycho-educational counselin, Turkish classical music Turkish classical music, MgSO4 And Slow Stroke Back Massage Therapy, Foot Massage Modification, Foot Massage Modificatio, Warm Footbath With Salt, Slow Sroke Back Massage. The conclusion is that almost all interventions affect blood pressure reduction in pregnant women with preeclampsia.
KESADARAN PEREMPUAN MENOPAUSE TENTANG KANKER SERVIKS DI DESA MARGAJAYA KABUPATEN SUMEDANG
Authors: Widiasih Restuning 
Published: June 2023

Kanker serviks merupakan jenis kanker tertinggi kedua yang menyerang wanita. Sebagian besar kanker serviks terjadi pada usia menopause yaitu usia 45-60 tahun. Kesadaran merupakan salah satu komponen penting dalam menurunkan angka kejadian kanker serviks. Penelitian ini bertujuan untuk mengidentifikasi kesadaran perempuan usia menopause tentang kanker serviks di Desa Margajaya Kabupaten Sumedang. Penelitian ini menggunakan design deskriptif kuantitatif. Sampel diambil dengan teknik stratified random sampling (n=200). Data dikumpulkan menggunakan instrumen Cervical Cancer Awareness Measure (CCAM). Penelitian ini menggunakan analisis univariat dengan distribusi frekuensi. Hasil penelitian didapatkan sebanyak (54%) responden memiliki kesadaran tinggi, (46%) responden memiliki kesadaran rendah. Adapun berdasarkan komponen mayoritas perempuan menopause memiliki kesadaran tinggi pada komponen tanda gejala (52,5%), faktor risiko(63,5%), usia yang berisiko kanker serviks(53%), kepercayaan diri mengenali tanda gejala (58,5%) dan kesadaran terkait program skrining kanker serviks (67%). Namun pada komponen kesadaran terkait program vaksinasi responden memiliki kesadaran yang rendah (46,5%). Oleh sebab itu,diharapkan petugas kesehatan dapat bekerjasama dengan staf kantor desa dan para kader dalam melakukan program preventif dan promotif yang rutin dan terjadwal agar dapat meingkatkan kesadaran masayarakat tentang kanker serviks. Kata kunci : Kanker serviks, kesadaran, dan menopause.