bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing the combination of Feeling Safe and Peer Counselling against Formulation-Based Cognitive Behavior Therapy to promote Psychological Wellbeing in People with Persecutory Delusions: Study Protocol for a Randomized Controlled Trial (the Feeling Safe-NL Trial).
Authors: Tolmeijer Eva , Waite Felicity , Isham Louise , Bringmann Laura , Timmers Robin , Berg Arjan van den , Schuurmans Hanneke , Staring Anton B. P. , de Bont Paul , Grunsven Rob van , Stulp Gert , Wijnen Ben , Gaag Mark van der , Freeman Daniel , Berg David van den 
Published: September 2023

Abstract
Background: Persecutory delusions are strong threat beliefs about others’ negative intentions. They can have a major impact on patients’ day-to-day life. The Feeling Safe Programme is a new translational cognitive-behavior therapy that helps patients modify threat beliefs and relearn safety by targeting key psychological causal factors. A different intervention approach, with growing international interest, is peer counselling to facilitate personal recovery. Combining these two approaches is a potential avenue to maximize patient outcomes. This combination of two different treatments will be tested as the Feeling Safe-NL Programme, which aims to promote psychological wellbeing. We will test whether Feeling Safe-NL is more effective and more cost-effective in improving mental wellbeing and reducing persecutory delusions than the current guideline intervention of formulation-based CBT for psychosis (CBTp).
Methods: A single-blind parallel group randomized controlled trial for 190 out-patients who experience persecutory delusions and low mental wellbeing. Patients will be randomized (1:1) to Feeling Safe-NL (Feeling Safe and peer counselling) or to formulation-based CBTp, both provided over a period of 6 months. Participants in both conditions are offered the possibility to self-monitor their recovery process. Blinded assessments will be conducted at 0, 6 (post-treatment), 12, and 18 months. The primary outcome is mental wellbeing. The overall effect over time (baseline to 18-month follow-up) and the effects at each timepoint will be determined. Secondary outcomes include severity of the persecutory delusion, general paranoid ideation, patient chosen therapy outcomes, and activity. Service use data and quality of life data will be collected for the health-economic evaluation.
Discussion: The Feeling Safe-NL trial is the first to evaluate a treatment for people with persecutory delusions, while using mental wellbeing as the primary outcome. It will also provide the first evaluation of the combination of a peer counselling intervention and CBT-based program for recovery from persecutory delusions.
Trial registration: Current Controlled Trials ISRCTN25766661 (retrospectively registered 7 July 2022)
Design, Optimization, Simulation, and Implementation of a 3D Printed Soft Robotic Peristaltic Pump
Authors: TOTUK Onat Halis , Mıstıkoğlu Selçuk , Güvenç Mehmet Ali 
Published: September 2023

Abstract
This paper presents an innovative approach to fluidic pumping, utilizing the principles of soft robotics. The focus is based on designing a pump that circulates fluid through a soft conduit by using a soft robotic pump. A parametric finite element model is developed to predict the required pressure for actuating the pump elements, and a meta-model is created to optimize the pressure for maximum flow rate with minimal power. The study employs the Mooney-Rivlin 5 Parameters hyper-elastic material model to ensure material properties are accurately accounted for. MATLAB Simulink Simscape modeling tool is used to mimic peristaltic pump motion and actuation sequences to calculate flow rates. The optimal design values are determined and experimental results are compared with simulation results to verify and validate the effectiveness of the approach. This study demonstrates that linearly sequenced soft squeeze actuators can be trans-formed into a scalable pump with proper control, providing a potential solution for delicate environments such as blood streams where circular peristaltic actuation may not be feasible.
The Relationship between Admission Blood Glucose Levels and Major Adverse Cardiovascular Events during Hospitalization in Non-Diabetic ST-Segment Elevation Myocardial Infarction (Killip I) Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Zhang Jing , Zeng Ping , Li Ruonan , Fan Zhixing , Huang Rihong , Cai Xinyong , Shao Liang , Liu Fuyuan , Lei Yuhua , Li Dongsheng , Jin Xing , Hu Zheng , Chen Xiangzhou , Yang Jun , Yang Jian 
Published: September 2023

Abstract
Background:
Our objective was to investigate the correlation between admission blood glucose (ABG) levels and the occurrence of in-hospital major adverse cardiovascular events (MACE) in non-diabetic patients (Killip class I), with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI).
Methods:
This retrospective observational study, registered in Clinical Trials (NCT04996901), included a total of 5586 patients with STEMI between January 2015 to August 2021. The occurrence of MACE was determined through the presence of acute heart failure and in-hospital death.
Results：
A total of 2890 patients were ultimately identified for inclusion in the study. These patients were categorized into three groups based on their ABG levels: Q1 (2.5-5.72 mmol/L), Q2 (5.73-7.0 mmol/L), and Q3 (7.01-11.0 mmol/L). Multivariate analysis, adjusting for age, gender, diastolic blood pressure (DBP), heart rate (HR), smoking, hypertension, and other factors, revealed that the odds ratio (OR) for MACE in Q2 and Q3 was 1.43-1.62 times higher compared to Q1 in calibration Models II to IV. Subgroup analysis indicated that the OR for Q2 was 3.52-fold higher in females and 1.54-fold higher in individuals aged 60 years or older. Sensitivity analysis, excluding patients with ABG levels below 4 mmol/L, still demonstrated a significant association between elevated ABG and increased risk of MACE. The area under the receiver operating characteristic (ROC) curve for ABG in predicting MACE occurrence after pPCI was 0.668, and the C-index in the calibration curve was 0.666. Cubic spline analysis further confirmed a significant decrease in MACE risk with ABG reduction below 6.3 mmol/L.
CONCLUSIONS:
In non-diabetic STEMI patients treated with pPCI, elevated ABG levels are linked to a higher risk of in-hospital MACE. Notably, this association is more pronounced in female patients and older individuals.
Optimising Pain Management in Paediatric Tonsillectomy: Evaluation of Intravenous Lidocaine at a 50% Efficacy Dose for Postoperative Throat Pain Prevention
Authors: Hu Yang , Zhu Guo , Chen Yi , Long Xiang , Jiang Jing , Zhang Qing , Qin Guan , GONG Yuan 
Published: September 2023

Abstract
Background:
Intravenous lidocaine is effective in preventing post-operative throat pain. However, concerns about lidocaine toxicity and limited administration methods persist. Consequently, the optimal 50% effective dose (ED50) of lidocaine for preventing post-operative throat pain in children undergoing tonsillectomy remains unclear.
Methods:
We enrolled 27 children aged 3 to 15 years who underwent tonsillectomy. A predetermined continuous lidocaine infusion (1.5 mg/kg) was administered throughout the surgery. Throat pain was assessed at 1 h post-operation using the Children’s and Infants’ Postoperative Pain Scale (CHIPPS) and visual analogue scale (VAS) scores. The lidocaine administration rate for each subsequent child was determined based on the scores. The initial child received lidocaine at a rate of 0.5 mg/kg/h, and subsequent children received higher rates if the CHIPPS or VAS score was ≥ 4 at 1 h post-operation. Those with a CHIPPS or VAS score < 4 received the same or lower rates. All patients received the same induction protocol (sufentanil, propofol, and rocuronium), and anaesthesia was maintained using sevoflurane. The primary outcome was the CHIPPS or VAS score for throat pain at 1 h post-operation. The secondary outcomes were post-operative nausea, vomiting, and time to extubation. Intra-operative respiratory and cardiac events were monitored for safety.
Results:
The ED50 of intravenous lidocaine for throat pain was determined to be 0.477 (0.378–0.617) mg/kg/h. The effective dose for preventing post-operative throat pain in 95% of patients administered lidocaine was 0.624 (0.545–2.458) mg/kg/h.
Conclusions:
Intravenous lidocaine (ED50) effectively treats post-operative throat pain in children.
TRIAL REGISTRATION:
This study was approved by the Institutional Review Board of Yichang Central People’s Hospital (HEC-KYJJ-2020-038-04) on 16 Feburary 2023. The trial was registered on 21 Mach 2023(21/03/2023) at www.chictr.org.cn (ChiCTR2300069567).
Knowledge and Habits on Oral Health of Highly Educated Women During Pregnancy and Their Babies. A Cross-sectional Questionnaire Survey in Northern-italy
Authors: Cagetti Maria Grazia , Salerno Claudia , Ionescu Andrei Cristian , Rocca Serena La , Camoni Nicole , Cirio Silvia , Campus Guglielmo 
Published: September 2023

Abstract

Background: Life-long healthy behaviors are established during pregnancy and the first years of life. This cross-sectional survey aimed to interview new mothers with a high level of schooling living in Northern Italy (Lombardy Region) to assess their knowledge and habits relating to their oral health and their children’s oral health.Methods: A questionnaire (27 items) was developed to assess socio-demographic factors, knowledge, and attitudes toward mothers’ and child’s oral health. The questionnaire was disseminated in perinatal courses, private gynecological clinics, andviasocial media. Mothers aged ≥ 18 years, with at least a child aged 0-36 months, with a high school diploma or higher, were included in the survey.Results: Overall, 1340 women completed the questionnaire, 1297 of whom had a child aged 0-36 months, 792 were residents in Lombardy, and 600 had a high level of education and were finally included. About half of the sample (44.67%) were between 31 and 35 years, 76.50% were employed, and the majority had only one child (81.50%). During pregnancy, 28.33% of the sample reported problems with teeth and/or gums, while only 36.00% visited a dentist. More than 40% of the sample reported not being aware of a possible correlation between oral health and pregnancy, and 73.17% did not receive advice about their oral health or the future health of the baby’s mouth. Less than 20% of the women was aware of the increased caries risk due to prolonged or nocturnal breastfeeding. Better knowledge/attitude was associated with the age of the child (p<0.01), the number of children (p=0.04), and whether the mother had received advice during pregnancy (p<0.01).Conclusions: The findings of the present survey show a lack of dental care during pregnancy, a lack of information on oral health received from medical personnel during and after pregnancy, and, consequently, gaps in the knowledge needed to care for her and her child’s oral health. There is a need for training courses on oral health for pregnant women and new mothers, but also for a change in the behaviour of health professionals who care for pregnant women.
Fractionation of the Caspian sand goby epidermal exudates Using Membrane Ultrafiltration and Reversed-phase chromatography: an investigation on bioactivities
Authors: Akhavan-Bahabadi Mohammad , Paknejad Hamed , Hedayati Aliakbar , Habibi-Rezaei Mehran 
Published: September 2023

Abstract
Bioactive peptide-based drugs have gained exceeding attention as promising treatments for infectious and oxidative-stress-related diseases, are exacerbated by the advent and spread of various multidrug-resistant bacteria and industrial lifestyles. Fish skin mucus has been recognized as a potential source of bioactive peptides, providing the first line of fish defense against invading pathogens which are targeted here to be explored as a new source of biopharmaceutics. Peptide fractions were isolated from the epidermal exudates of Caspian sand goby, Neogobius fluviatilis pallasi, by solid-phase extraction (SPE), ultrafiltration, and reversed-phase chromatography. The resulting fractions were characterized for their antibacterial and antioxidant properties, and results showed that the molecular weight fraction < 5 kDa represented the highest (P < 0.05) bacterial inhibition activity against Staphylococcus aureus and Bacillus subtilis as well as scavenging activity against DPPH and ABTS radicals. Overall, these results introduce the epidermal mucus of Caspian sand goby as a valuable source of bioactive compounds that can be considered new and efficient biopharmaceutics.
Bawei Chenxiang Wan ameliorates right ventricular hypertrophy in rats with high altitude heart disease by SIRT3-HIF1α-PDK/PDH signaling pathway improving fatty acid and glucose metabolism
Authors: Han Yiwei , Li Shadi , Zhang Zhiying , Ning Xin , Wu Jiajia , Zhang Xiaoying 
Published: September 2023

Abstract
Background
Bawei Chenxiang Wan (BCW) is among the most effective and widely used therapies for coronary heart disease and angina pectoris in Tibet. However, it is unknown whether it confer protection through right ventricle (RV) myocardial metabolic mechanism.
Methods
Male Sprague–Dawley rats were oral administration BCW, injected concurrently with a bolus of Sugen5416 (SU5416) and hypoxia exposure (5000m altitude) for 4 weeks(SuHx). Right ventricular hypertrophy (RVH) in high altitude heart disease (HAHD) was assessed using Fulton's index (FI; ratio of RV to left ventricle (LV) +septum weights) and heart weight to body weight ratio (HW/BW). The effect of therapeutic administration of BCW in the RVH on hemodynamics assessed by catheterization [right ventricular and Pulmonary artery pressure (mRVP and mPAP, respectively)]. Tissue samples were used to perform a histological staining, mRNA and protein levels confirmatory analyses to identify altered the mechanisms within the RVH in HAHD. Further verify the protective mechanism of BCW was studied in cell culture.
Results
BCW significantly reduced SuHx-associated RVH, indicated by macro morphology, HW/BW ratio, Fulton index, mPAP, mRVP, hypertrophy markers, heart function, pathological structure, and the myocardial enzymes. Moreover, BCW can also alleviate the disorder of glucose and fatty acid metabolism by up-regulating carnitine palmitoyltransferase1ɑ (CPT1ɑ), citrate synthase (CS), acetyl-CoA, down-regulating glucose transport-4 (GLUT-4), Phosphofructokinase (PFK), pyruvate, resulting in the reduction of Free fatty acids (FFA), lactic acid (LD) and the increase of aerobic oxidation. This process may be mediated by regulating sirtuin3 (SIRT3)-Hypoxia-inducible factor 1α (HIF1α)-pyruvate dehydrogenase kinase(PDK)/pyruvate dehydrogenase (PDH) signaling pathways. Subsequently, inhibition of SIRT3 expression by 3-TYP (a selective inhibitor of SIRT3) significantly can reverse the anti-RVH in HAHD effect of BCW indicated by hypertrophy markers and serum myocardial enzyme levels.
Conclusions
In conclusion, BCW prevents SuHx-induced RVH in HAHD by SIRT3-HIF1ɑ-PDK/PDH signaling pathway to alleviate the disturbance in fatty acid and glucose metabolism. Therefore, BCW can be used as an alternative drug for the treatment of RVH in HAHD.
The mediating effect of impulsivity between mindfulness and smartphone addiction
Authors: Kim Minjung , Seong Goeun , Jeon Min-Jeong , Jung Young-Chul , Lee Deokjong 
Published: September 2023

Abstract

ObjectiveProblematic smartphone usage may have negative effects on various psychological traits: e.g., studies have indicated that it is accompanied by low levels of mindfulness and high impulsivity. This study explored the psychological mechanism of problematic smartphone usage via the relationship between addictive smartphone use patterns, mindfulness and impulsivity.MethodsNinety participants were evaluated with the Smartphone Addiction Proneness Scale and classified into the problematic smartphone usage group (n=42; 24 women; mean age: 27.6±7.2 years) or normal usage group (n=48; 22 women; mean age: 30.1±5.7 years). All participants completed self-report questionnaires evaluating their affective symptoms, impulsivity and mindfulness and computerized comprehensive attention tests that assessed selective, sustained and divided attention. We compared the variables between the groups and explored the relationship between mindfulness, impulsivity and addictive smartphone use patterns through mediation analysis.ResultsThe problematic smartphone usage group showed higher impulsivity and lower mindfulness than the normal usage group. There were no significant group differences in attention test performance. The level of addictive patterns was significantly correlated with impulsivity and mindfulness levels but not attention test performance. In the mediation analysis, acting with awareness (a facet of mindfulness) reduced levels of addictive smartphone use patterns through attentional impulsivity.ConclusionActing without sufficient awareness could influence addictive smartphone use patterns by mediating attentional impulsivity. This supports existing evidence that the executive control deficits present in high impulsivity contribute to problematic smartphone use. Cognitive behavioural therapy for mindfulness could strengthen executive control over smartphone usage by promoting awareness.
Advances in the Application of Artificial Intelligence Technology in the Frailty State of Elderly Heart Failure Patients
Authors: Zhou Qian , Li Daohong , Lv Rong , Wu Lijiao , Qiao Huiying 
Published: September 2023

Abstract
With social ageing, the prevalence of heart failure (HF) rises. As an end-stage symptom of heart disease, HF usually shows poor clinical prognosis and even threatens patients’ lives. As a senile syndrome, frailty has significant impacts on the developmental outcomes of HF patients (mortality, readmission rate, and body function). Hence, frailty should be clinically identified and alleviated in time to improve the prognosis for patients. Patients and medical workers should pay more attention to frailty to lower the incidence of adverse events, improve the survival, and prolong survival time among HF patients. Besides, it is essential to perform early clinical diagnosis and treatment of HF. With the development of science, artificial intelligence (AI) shows great potential in heart disease. At present, AI is applied in the auxiliary diagnosis and treatment of HF, which brings about great reform in the prevention, diagnosis, and treatment of clinical diseases. Therefore, brief and comprehensive exploration and analysis were performed on the relationship between senile HF and frailty and the effects of frailty on the prognosis for patients to enable readers to further understand the effects of frailty on HF and to concern more on HF combined with frailty. What’s more, applying AI in the diagnosis and treatment of HF was investigated and its advantages and limitations were analyzed to provide basis for further enhancing performance of AI in HF and improve clinical diagnostic accuracy for HF patients and poor prognosis.
Feasibility and acceptability of a contextualized physical activity and diet intervention for the control of hypertension in adults from a rural sub-district: A study protocol (HYPHEN)
Authors: Sekome Kganetso , Gómez-Olivé Francesc Xavier , Sherar Lauren B , Esliger Dale W , Myezwa Hellen 
Published: September 2023

Abstract
Introduction: In rural and remote South Africa, most strokes and ischaemic heart diseases are as a consequence of hypertension, which is a modifiable risk factor. The widely recommended therapeutic approaches to control hypertension are through physical activity and diet modifications. However, there is a lack of culturally sensitive community-based, lifestyle interventions to control hypertension among rural African adult populations. We designed an intervention which recommends adjusting daily routine physical activity and dietary behaviour of adults with hypertension. This study aims to evaluate the feasibility and acceptability of HYPHEN in a rural community setting. Methods: We aim to recruit 30 adult participants with a self-report hypertension diagnosis. A one-arm, prospective design will be used to assess the feasibility and acceptability of recruitment, uptake, engagement, and completion of the 10-week intervention. Recruitment rates will be assessed at week 0. Intervention uptake, engagement, and adherence to the intervention will be assessed weekly via telephone. Blood pressure, body mass index, waist-hip ratio, urinary sodium, accelerometer measured physical activity, and 24hour diet recall will be assessed at baseline and at 10-weeks. Qualitative semi-structured interviews will be conducted at 10 weeks to explore feasibility and acceptability. Discussion: This study offers a person-centred, sociocultural approach to hypertension control through adaptations to physical activity and dietary intake. This study will determine whether HYPHEN is feasible and acceptable and will inform changes to the protocol/focus that could be tested in a full trial. Trial registration number: PACTR202306662753321.
Combined Allergic bronchopulmonary mycosis and Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Literature Review
Authors: Cui Ning , Wang Jingluan , Shao Yanmei , Zhao Jingming , Cheng Zhaozhong 
Published: September 2023

Abstract
Background: Several diagnostic criteria are common for Allergic bronchopulmonary mycosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). There were few reports of cases where ABPM and EGPA coexist. Here, we present a patient who simultaneously met the diagnostic criteria for both ABPM and EGPA.
Case presentation: A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from bronchoalveolar lavage fluid. Furthermore, glucocorticoids therapy is effective. Conclusions: These results met the diagnostic criteria for both ABPM and EGPA. We also reviewed several reported cases of coexistence of ABPM and EGPA so far. Special attention should be paid to the possibility of both diseases coexisting in the disease process.