bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KINERJA KEUANGAN, KEBIJAKAN DIVIDEN DAN KEBIJAKAN HUTANG TERHADAP NILAI PERUSAHAAN
Authors: Wahiddirani Saputri Sevty , Oktavianna Rakhmawati , Benarda Benarda 
Published: February 2023

ABSTRAK
Penelitian ini bertujuan untuk mengkaji pengaruh Kinerja Keuangan/Profitabilitas, kebijakan dividen, dan kebijakan utang terhadap nilai perusahaan. Kinerja keuangan diukur dengan Return on Assets, kebijakan dividen diukur dengan menggunakan Dividend Payout Ratio. Kebijakan Utang diukur dengan menggunakan Debt to Equity Ratio. Nilai perusahaan diukur menggunakan harga pasar per saham dibagi dengan nilai buku per saham. Populasi dalam penelitian ini adalah semua perusahaan properti dan real estat yang terdaftar di Bursa Efek Indonesia pada tahun 2016-2020. Jumlah sampel dalam penelitian ini sebanyak 17 perusahaan yang diperoleh melalui purposive sampling. Memperoleh data sampel sebanyak 85 data. Jenis data dalam penelitian ini adalah data sekunder dengan metode penelitian kuantitatif dan pendekatan deskriptif. Teknik analisis yang digunakan adalah analisis regresi data panel dengan tingkat signifikansi 5% (0,05). Penelitian ini diproses menggunakan software views 9.0 dan menunjukkan bahwa (1) Secara bersamaan kinerja/profitabilitas keuangan. Kebijakan dividen dan kebijakan utang mempengaruhi nilai perusahaan. (2) sebagian kinerja/profitabilitas keuangan tidak berpengaruh signifikan terhadap nilai perusahaan (3) sebagian kebijakan dividen berpengaruh signifikan terhadap nilai perusahaan (4) sebagian kebijakan utang tidak berpengaruh signifikan terhadap nilai perusahaan.
Injured nerves respond favorably to an integrated tension- and conduit-based regenerative strategy
Authors: Chuang Ting-Hsien , Orozco Elisabeth , Nam Jae Jun , Vaz Kenneth , Lovering Richard M. , Shah Sameer B. 
Published: February 2023

Introduction: Numerous synthetic, hybrid, and biological grafts and conduits have been deployed to facilitate axonal regeneration across peripheral nerve gaps. Though some strategies have showed promise, larger gaps continue to be an unsolved clinical challenge. Recent evidence suggests that tension-based strategies offer a promising alternative approach to nerve repair. However, whether and to what degree severed peripheral nerves tolerate and accommodate tension, especially in the critical early stages of intervention, is less clear.Methods: In this study, we evaluated a number of immuno-histochemical outcomes to test the hypothesis that injured rat sciatic nerves accommodate strains of up to 20%, a deformation magnitude that exceeds oft-quoted thresholds for nerve damage. We also assessed the possibility of integrating tension with conduit-based approaches for nerve repair.Results and Discussion: There were no deficits in axonal, basal laminar, or extracellular matrix morphology with tension, though proximal and distal stumps of nerves in all experimental groups displayed abnormal morphology in proximity to the site of injury. Axons of stretched nerves successfully grew through guidance conduits into the distal stump within 6 weeks of repair, thus demonstrating the feasibility of combining tension- and conduit-based regenerative strategies.
Short-term effects of Chlorhexidine mouthwash and Listerine on oral microbiome in hospitalized patients
Authors: Liu Tsunglin , Chen Yen-Chin , Jeng Shuen-Lin , Chang Jui-Jen , Wang Jiu-Yao , Lin Cheng-Han , Tsai Pei-Fang , Ko Nai-Ying , Ko Wen-Chien , Wang Jiun-Ling 
Published: February 2023

IntroductionChlorhexidine (CHX) and essential oil containing mouthwashes like Listerine® can improve oral hygiene via suppressing oral microbes. In hospitalized patients, CHX mouthwash reduces the incidence of ventilator-associated pneumonia. However, CHX use was also associated with increased mortality, which might be related to nitrate-reducing bacteria. Currently, no study determines oral bacteria targeted by essential oils mouthwash in hospitalized patients using a metagenomic approach.MethodsWe recruited 87 hospitalized patients from a previous randomized control study, and assigned them to three mouthwash groups: CHX, Listerine, and normal saline (control). Before and after gargling the mouthwash twice a day for 5-7 days, oral bacteria were examined using a 16S rDNA approach.ResultsAlpha diversities at the genus level decreased significantly only for the CHX and Listerine groups. Only for the two groups, oral microbiota before and after gargling were significantly different, but not clearly distinct. Paired analysis eliminated the substantial individual differences and revealed eight bacterial genera (including Prevotella, Fusobacterium, and Selenomonas) with a decreased relative abundance, while Rothia increased after gargling the CHX mouthwash. After gargling Listerine, seven genera (including Parvimonas, Eubacterium, and Selenomonas) showed a decreased relative abundance, and the magnitudes were smaller compared to the CHX group. Fewer bacteria targeted by Listerine were reported to be nitrate-reducing compared to the CHX mouthwash.DiscussionIn conclusion, short-term gargling of the CHX mouthwash and Listerine altered oral microbiota in our hospitalized patients. The bacterial genera targeted by the CHX mouthwash and Listerine were largely different and the magnitudes of changes were smaller using Listerine. Functional alterations of gargling CHX and Listerine were also different. These findings can be considered for managing oral hygiene of hospitalized patients.
Global research trends of hypertrophic cardiomyopathy from 2000 to 2022: Insights from bibliometric analysis
Authors: Zheng Xifeng , He Zhongkai , Li Ming , Jia Zhen 
Published: February 2023

ObjectivesTo analyze the global research trends of hypertrophic cardiomyopathy (HCM) from 2000 to 2022 and explore new frontiers in this field.MethodsWe reviewed the literature in the Web of Science Core Collection database from January 2000 to August 2022 using the retrieval strategy of medical subject headings combined with text words. We focused on articles and reviews that were published in English. Relevant data of the target publications, such as title, authors, organizations, abstract, keywords, published date, journal, and number of citations, were collected. The R software with the “bibliometrix” and VOSviewer software was used to process and visualize the information.ResultsAmong a total of 20,581 records related to HCM, 13,427 from 103 countries and regions, 8,676 affiliations, and 46,645 researchers were included. Most of the publications in this field were from the United States, followed by Japan, the United Kingdom, and China. We also report the top 10 institutions and most influential researchers, cited articles, and highest-frequency keywords (echocardiography, heart failure, sudden cardiac death, genetics, atrial fibrillation, magnetic resonance imaging/cardiac magnetic resonance, prognosis, mutation, arrhythmia, late gadolinium enhancement). In addition, keywords trend analysis indicated that the novel medicine Mavacamten, genetic diagnosis, and cardiac magnetic resonance have attracted the most attention for the treatment and diagnosis of HCM over the past five years.ConclusionThe present study reports on the global research trends of HCM over the past two decades using bibliometric analysis. It may enlighten new frontiers in the diagnosis, treatment, and risk prevention of HCM.
Effect of blood flow–restricted resistance training on myocardial fibrosis in early spontaneously hypertensive rats
Authors: Tan Zhaowen , Chen Peiyou , Zheng Yuchan , Pan Ying , Wang Baolong , Zhao Yan 
Published: February 2023

ObjectiveThe purpose of this study was to explore the effect of blood flow–restricted resistance training on myocardial fibrosis in early spontaneously hypertensive rats (SHRs).MethodsFour-week-old male Wistar-Kyoto rats and SHRs were randomly divided into the following groups: normal group (WKY), SHR control (SHR-SED) group, high-intensity resistance training (HIRT) group, low- and medium-intensity resistance training (LMIRT) group, and blood flow–restricted low- and medium-resistance training (BFRT) group. Body weight, hemodynamics, cardiac function, myocardial morphology and fibrosis, and the expression levels of transforming growth factor-beta1-Smad (TGFβ-1-Smad) pathway-related proteins in the myocardium were assessed.Results(1) BFRT lowered blood pressure significantly, decreased left ventricular wall thickness, and improved cardiac function. At the same time, BFRT was superior to traditional resistance training in lowering diastolic blood pressure, and was superior to HIRT in improving left ventricular compliance, reducing heart rate, and reducing left ventricular posterior wall and left ventricular mass (P &lt; 0.05). (2) BFRT decreased collagen I and collagen fiber area in the myocardium, increased the collagen III area, and decreased the collagen I/III ratio (P &lt; 0.05). BFRT produced a better proportion of myocardial collagen fibers than did traditional resistance training (P &lt; 0.05). (3) In the myocardium of the BFRT group compared to the traditional resistance training group, the expression of TGFβ-1, Smad2/3/4, p-Smad2/3, CTGF, and TIMP1 was significantly downregulated, MMP2 and TIMP2 were significantly upregulated, the MMP/TIMP ratio significantly increased, and TGFβ-1 expression significantly decreased (P &lt; 0.05).ConclusionBFRT inhibited the TGFβ-1-Smad pathway in the myocardium, downregulated the expression of CTGF, and regulated the balance between MMPs and TIMPs, thereby reducing myocardial fibrosis in SHR, and improving cardiac morphology and function. BFRT also lowered blood pressure, and achieved an effect of early prevention and treatment of hypertension. At the same time, BFRT was superior to traditional resistance training in reducing diastolic blood pressure and adjusting the proportion of myocardial collagen fibers.
Large parathyroid adenomas: Potential mechanisms to reconcile adenoma size and disease phenotype
Authors: Bhan Arti , Athimulam Shobana , Kumari Poonam , Pal Rimesh , Bhadada Sanjay Kumar , Cook Bernard C. , Qiu Shijing , Rao Sudhaker D. 
Published: February 2023

Parathyroid adenomas weighing more than 3.5 g are reported variously as “atypical”, “large” or “giant” parathyroid adenomas. All such adenomas are rare variants accounting for no more than 1.5% of all parathyroid adenomas. Large parathyroid adenomas are often associated with more severe form of the disease, including osteitis fibrosa cystica (OFC) and share many biochemical, histological, and molecular features of both benign and malignant parathyroid neoplasms, and are considered a distinct clinical entity. However, the pathogenesis of oversized parathyroid adenomas and the often-associated skeletal phenotype remains unclear. We present 5 cases of primary hyperparathyroidism (PHPT) with OFC, an uncommon manifestation of contemporary PHPT, associated with larger parathyroid adenomas, seen in the Bone and Mineral Disorders Clinic of the Henry Ford Health in the last 30 years to illustrate the critical role of vitamin D nutrition in the pathogenesis of both the OFC and adenoma size. The estimated prevalence of OFC was very low 0.2%, 5 of the &gt;3000 surgically confirmed cases of PHPT seen during this time. The mean ± SD values were: age: 36.8 ± 22.1 years (4 of the 5 &lt;36years), serum calcium 11.6 ± 1.1 mg/dl, alkaline phosphatase 799 ± 487 IU/L, PTH 1440 ± 477 pg/ml, 25-hydroxyvitamin D 13.0 ± 8.9 ng/ml, 1,25-dihyroxyvitamin D 26.5 ± 13.7 pg/ml, urine calcium 562 ± 274 mg/day, and parathyroid adenoma weight 4.53 ± 2.2 g. Parathyroidectomy led to the resolution of both the biochemical indices and OFC in each patient without recurrence over &gt;10 years of follow-up. Because OFC is a very rare in the West, but very common areas of endemic vitamin D deficiency, we also examined the relationship between vitamin D nutrition, as assessed by serum 25-hydroxyvitamin D level, and parathyroid adenoma weight as well as prevalence of OFC in two large secularly diverse cohorts of patients with PHPT (Detroit, USA and Chandigarh, India). Based on this relationship and the relative prevalence of OFC in these two large cohorts, we propose that vitamin D nutrition (and perhaps calcium nutrition) best explains both the adenoma size and prevalence of OFC.
Effects of the ketogenic diet on bone health: A systematic review
Authors: Garofalo Vincenzo , Barbagallo Federica , Cannarella Rossella , Calogero Aldo Eugenio , La Vignera Sandro , Condorelli Rosita Angela 
Published: February 2023

ObjectiveTo carry out a systematic review of published studies to evaluate the relationship between different type of ketogenic diet (KD) and bone health as supported by the scientific literature.MethodsThe study involved all articles that assessed the relationship between the use of KD for the treatment of overweight or obesity and bone health. The quality assessment was evaluated with using the Cambridge Quality Checklists. The search strategy included the following combination of Medical Subjects Headings terms and keywords: “osteoporosis”, ”bone health, ”bone function”, ”bone mineral density”, and “ketogenic diet”.ResultsSeven trials were identified and reviewed. No significant changes in bone mass density (BMD) were observed after KD. The results showed no significant effect on bone resorption by measuring urinary N-telopeptide levels, on bone formation by measuring bone-specific alkaline phosphatase, or alterations in overall bone turnover in patients who followed KD. Only in female subject after a 10% weight loss, bone resorption increases while new bone synthesis decreases, but without increasing the risk of osteoporosis. Finally, patients on KD lost significantly more weight than controls, associated with an increase in serum vitamin D levels and a reduction in plasma parathyroid hormone (PTH) levels.ConclusionNo human studies have currently been conducted with adequate and powerful experimental designs to definitively understand the impact of KD therapy on bone health.
Indoxyl sulfate mediates low handgrip strength and is predictive of high hospitalization rates in patients with end-stage renal disease
Authors: Hou Yi-Chou , Liu Yueh-Min , Liao Min-Ter , Zheng Cai-Mei , Lu Chien-Lin , Liu Wen-Chih , Hung Kuo-Chin , Lin Shyh-Min , Lu Kuo-Cheng 
Published: February 2023

Background and aimsSarcopenia has a higher occurrence rate in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Low handgrip strength—and not sarcopenia per se—is associated with clinical outcomes in patients with CKD, including cardiovascular mortality and hospitalization. The factors contributing to low handgrip strength are still unknown. Accordingly, this study aimed to determine whether uremic toxins influence low handgrip strength in patients with CKD.Materials and methodsThis cohort study lasted from August 2018 to January 2020. The participants were divided into three groups: the control group [estimated glomerular filtration rate (eGFR) ≥ 60 ml/min], an advanced CKD group (eGFR = 15–60 ml/min), and an ESRD group (under maintenance renal replacement therapy). All participants underwent handgrip strength measurement, dual-energy X-ray absorptiometry, and blood sampling for myokines (irisin, myostatin, and interleukin 6) and indoxyl sulfate. Sarcopenia was defined according to the Asian Working Group for Sarcopenia consensus as low appendicular skeletal muscle index (appendicular skeletal muscle/height2 of &lt; 7.0 kg/m2 in men and &lt; 5.4 kg/m2 in women) and low handgrip strength (&lt; 28 kg in men and &lt; 18 kg in women).ResultsAmong the study participants (control: n = 16; CKD: n = 17; and ESRD: n = 42), the ESRD group had the highest prevalence of low handgrip strength (41.6 vs. 25% and 5.85% in the control and CKD groups, respectively; p &lt; 0.05). The sarcopenia rate was similar among the groups (12.5, 17.6, and 19.5% for the control, CKD, and ESRD groups, respectively; p = 0.864). Low handgrip strength was associated with high hospitalization rates within the total study population during the 600-day follow-up period (p = 0.02). The predictions for cardiovascular mortality and hospitalization were similar among patients with and without sarcopenia (p = 0.190 and p = 0.094). The serum concentrations of indoxyl sulfate were higher in the ESRD group (227.29 ± 92.65 μM vs. 41.97 ± 43.96 μM and 6.54 ± 3.45 μM for the CKD and control groups, respectively; p &lt; 0.05). Myokine concentrations were similar among groups. Indoxyl sulfate was associated with low handgrip strength in univariate and multivariate logistic regression models [univariate odds ratio (OR): 3.485, 95% confidence interval (CI): 1.372–8.852, p = 0.001; multivariate OR: 8.525, 95% CI: 1.807–40.207, p = 0.007].ConclusionHandgrip strength was lower in the patients with ESRD, and low handgrip strength was predictive of hospitalization in the total study population. Indoxyl sulfate contributed to low handgrip strength and counteracted the benefits of myokines in patients with CKD.
Non-pharmacological prevention of postoperative delirium by occupational therapy teams: A randomized clinical trial
Authors: Alvarez Evelyn A. , Rojas Veronica A. , Caipo Lorena I. , Galaz Melany M. , Ponce Daniela P. , Gutierrez Rodrigo G. , Salech Felipe , Tobar Eduardo , Reyes Fernando I. , Vergara Rodrigo C. , Egaña Jose I. , Briceño Constanza A. , Penna Antonello 
Published: February 2023

BackgroundPatients who develop postoperative delirium (POD) have several clinical complications, such as increased morbidity, increased hospital stays, higher hospital costs, cognitive and functional impairment, and higher mortality. POD is a clinical condition preventable by standard non-pharmacological measures An intensive Occupational Therapy (OT) intervention has been shown to be highly effective in preventing delirium in critically ill medical patients, but it is unknown the effect in surgical patients. Thus, we designed a prospective clinical study with the aim to determine whether patients undergoing intervention by the OT team have a lower incidence of POD compared to the group treated only with standard measures.MethodsA multicenter, single-blind, randomized clinical trial was conducted between October 2018 and April 2021, in Santiago of Chile, at a university hospital and at a public hospital. Patients older than 75 years undergoing elective major surgery were eligible for the trial inclusion. Patients with cognitive impairment, severe communication disorder and cultural language limitation, delirium at admission or before surgery, and enrolled in another study were excluded. The intervention consisted of OT therapy twice a day plus standard internationally recommended non-pharmacological prevention intervention during 5 days after surgery. Our primary outcome was development of delirium and postoperative subsyndromal delirium.ResultsIn total 160 patients were studied. In the interventional group, treated with an intensive prevention by OT, nine patients (12.9%) developed delirium after surgery and in the control group four patients (5.5%) [p = 0.125, RR 2.34 CI 95 (0.75–7.27)]. Whereas subsyndromal POD was present in 38 patients in the control group (52.1%) and in 34 (48.6%) in the intervention group [p = 0.4, RR 0.93 CI95 (0.67–1.29)]. A post hoc analysis determined that the patient’s comorbidity and cognitive status prior to hospitalization were the main risk factors to develop delirium after surgery.DiscussionPatients undergoing intervention by the OT team did not have a lower incidence of POD compared to the group treated only with standard non-pharmacological measures in adults older than 75 years who went for major surgery.Clinical trial registrationwww.ClinicalTrials.gov, identifier NCT03704090.
Six-month follow-up after recovery of COVID-19 Delta variant survivors via CT-based deep learning
Authors: Huang Jianliang , Lin Ruikai , Bai Na , Su Zhongrui , Zhu Mingxin , Li Han , Chai Conghai , Xia Mingkai , Shu Ziwei , Qiu Zhaowen , Lei Mingsheng 
Published: February 2023

PurposeUsing computer-aided diagnosis (CAD) methods to analyze the discharge and 6-month follow-up data of COVID-19 Delta variant survivors, evaluate and summarize the recovery and prognosis, and improve people's awareness of this disease.MethodsThis study collected clinical data, SGRQ questionnaire results, and lung CT scans (at both discharge and 6-month follow-up) from 41 COVID-19 Delta variant survivors. Two senior radiologists evaluated the CT scans before in-depth analysis. Deep lung parenchyma enhancing (DLPE) method was used to accurately segment conventional lesions and sub-visual lesions in CT images, and then quantitatively analyze lung injury and recovery. Patient recovery was also measured using the SGRQ questionnaire. The follow-up examination results from this study were combined with those of the original COVID-19 for further comparison.ResultsThe participants include 13 males (31.7%) and 28 females (68.3%), with an average age of 42.2 ± 17.7 years and an average BMI of 25.2 ± 4.4 kg/m2. Compared discharged CT and follow-up CT, 48.8% of survivors had pulmonary fibrosis, mainly including irregular lines (34.1%), punctuate calcification (12.2%) and nodules (12.2%). Compared with discharged CT, the ground-glass opacity basically dissipates at follow-up. The mean SGRQ score was 0.041 (0–0.104). The sequelae of survivors mainly included impaired sleep quality (17.1%), memory decline (26.8%), and anxiety (21.9%). After DLPE process, the lesion volume ratio decreased from 0.0018 (0.0003, 0.0353) at discharge to 0.0004 (0, 0.0032) at follow-up, p &lt; 0.05, and the absorption ratio of lesion was 0.7147 (–1.0303, 0.9945).ConclusionThe ground-glass opacity of survivors had dissipated when they were discharged from hospital, and a little fibrosis was seen in CT after 6-month, mainly manifested as irregular lines, punctuate calcification and nodules. After DLPE and quantitative calculations, we found that the degree of fibrosis in the lungs of most survivors was mild, which basically did not affect lung function. However, there are a small number of patients with unabsorbed or increased fibrosis. Survivors mainly had non-pulmonary sequelae such as impaired sleep quality and memory decline. Pulmonary prognosis of Delta variant patients was better than original COVID-19, with fewer and milder sequelae.
Analysis of microbial diversity in the feces of Arborophila rufipectus
Authors: Ma Xiaoping , Li Junshu , Chen Benping , Li Xinni , Ling Zhenwen , Feng Shenglin , Cao Sanjie , Zuo Zhicai , Deng Junliang , Huang Xiaobo , Cai Dongjie , Wen Yiping , Zhao Qin , Wang Ya , Zhong Zhijun , Peng Guangneng , Jiang Yaozhang , Gu Yu 
Published: February 2023

IntroductionIntestinal microbiota composition plays a crucial role in modulating the health of the host. This evaluation indicator is very sensitive and profoundly impacts the protection of endangered species. Currently, information on the gut microbiota of wild birds remains scarce. Therefore, this study aimed to describe the gut microbial community structure and potentially, the pathogen composition of wild Arborophila rufipectus.MethodsTo guarantee comprehensive data analysis, we collected fecal samples from wild A. rufipectus and Lophura nycthemera in their habitats for two quarters. The 16S rRNA gene was then sequenced using high-throughput sequencing technology to examine the intestinal core microbiota, microbial diversity, and potential pathogens with the aim of determining if the composition of the intestinal microflora varies seasonally.Results and DiscussionThe gut microbiota of A. rufipectus and L. nycthemera primarily comprised four phyla: Proteobacteria (45.98%), Firmicutes (35.65%), Bacteroidetes (11.77%), and Actinobacteria (3.48%), which accounted for 96.88% of the total microbial composition in all samples. At the genus level, core microorganisms were found, including Shigella (10.38%), Clostridium (6.16%), Pseudomonas (3.03%), and Rickettsiella (1.99%). In these genera, certain microbial species have been shown to be pathogenic. This study provides important indicators for analyzing the health status of A. rufipectus and formulating protective measures.