bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parkinson’s Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson’s Disease Progression
Authors: Brumm Michael C. , Siderowf Andrew , Simuni Tanya , Burghardt Elliot , Choi Seung Ho , Caspell-Garcia Chelsea , Chahine Lana M. , Mollenhauer Brit , Foroud Tatiana , Galasko Douglas , Merchant Kalpana , Arnedo Vanessa , Hutten Samantha J. , O’Grady Alyssa N. , Poston Kathleen L. , Tanner Caroline M. , Weintraub Daniel , Kieburtz Karl , Marek Kenneth , Coffey Christopher S. ,   on behalf of the Parkinson’s Progression Markers Initiative
Published: July 2023

Background: Identifying a meaningful progression metric for Parkinson’s disease (PD) that reflects heterogeneity remains a challenge. Objective: To assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD milestones. Methods: Using data from the Parkinson’s Progression Markers Initiative (PPMI) de novo PD cohort, we monitored 25 milestones across six domains (“walking and balance”; “motor complications”; “cognition”; “autonomic dysfunction”; “functional dependence”; “activities of daily living”). Milestones were intended to be severe enough to reflect meaningful disability. We assessed the proportion of participants reaching any milestone; evaluated which occurred most frequently; and conducted a time-to-first-event analysis exploring whether baseline characteristics were associated with progression. Results: Half of participants reached at least one milestone within five years. Milestones within the cognitive, functional dependence, and autonomic dysfunction domains were reached most often. Among participants who reached a milestone at an annual follow-up visit and remained active in the study, 82% continued to meet criteria for any milestone at one or more subsequent annual visits and 55% did so at the next annual visit. In multivariable analysis, baseline features predicting faster time to reaching a milestone included age ( p < 0.0001), greater MDS-UPDRS total scores ( p < 0.0001), higher GDS-15 depression scores ( p = 0.0341), lower dopamine transporter binding ( p = 0.0043), and lower CSF total α-synuclein levels ( p = 0.0030). Symptomatic treatment was not significantly associated with reaching a milestone ( p = 0.1639). Conclusion: Clinically relevant milestones occur frequently, even in early PD. Milestones were significantly associated with baseline clinical and biological markers, but not with symptomatic treatment. Further studies are necessary to validate these results, further assess the stability of milestones, and explore translating them into an outcome measure suitable for observational and therapeutic studies.
Autism – A brief update
Authors: Skjeldal Ola Hunsbeth , Isaksen Jørn 
Published: July 2023

Autism is a group of neurodevelopmental disorders that involve definite impairments in social interactions, disturbance in language, and a stereotyped pattern of behaviour. These clinical features are described as the core symptoms. The condition represents a very large number of diseases and syndromes that are individually rare. Therefore, most people will refer to autism in the plural – autisms. The prevalence of autism has increased incredibly in the last three decades. However, although the number of people diagnosed with autism has increased, this is not the same as saying that there is an increase in the number of cases of autism. Most likely, many children and adults 40–50 years ago had autistic behaviour that went under other diagnoses. The cause of the autistic features has been thoroughly discussed for many years and has been the subject of many research activities. The dominant view today is that genetic and environmental factors mainly cause autism. In this article we want to give a brief status quo of the clinic, epidemiology and causes of autism.
Aplikasi Pemesanan Menu Makanan dan Minuman pada K&Y Coffee berbasis Android
Authors: Asfaroni Farid , Amalia Rahayu 
Published: July 2023

Penelitian ini bertujuan untuk membuat aplikasi pemesanan menu makanan dan minuman pada K&Y Coffee berbasis android. Saat ini K&Y Coffee masih menggunakan cara manual sederhana dalam proses pemesanan menu. Dimana pihak kafe dan pelanggan masih menggunakan pena dan kertas sebagai media pemesanan. Cara tersebut masih belum efisien, dimana pelanggan masih menunggu dan mengantri untuk proses pemesanan serta pemilik kafe masih kesusahan dalam memonitoring pemesanan, mengeloa menu dan melihat laporan penjualan. Oleh karena itu penggunaan teknologi informasi akan sangat membantu dalam proses pemesanan. Dalam penelitian ini, metode yang digunakan adalah pemilihan jenis data, yaitu data primer yang diperoleh dari observasi, studi pustaka dan wawancara. Sedangkan metode yang digunakan dalam pembangunan sistem ini adalah metode Extreme Programming. Implementasi dari penelitian ini menggunakan Android Studio dengan bahasa pemrograman Java, Kotlin, PHP (Hypertext Preprocessor). Database yang digunakan adalah My SQL (My Structured Query Language) dan UML (Unified Modeling Language) sebagai alat untuk merancang sistem serta pengujian dari sistem ini menggunakan BlackBoxTesting. Hasil dari penelitian ini adalah sebuah sistem yang akan memudahkan pemilik kafe dalam mengelola menu dan melihat laporan penjualan serta memudahkan karyawan dan pelanggan dalam proses pemesanan menu.
Payment Tutoring System Reengineering Using Business Process Reengineering
Authors: Purwanto Hari Lugis , Pranata Kurriawan Budi 
Published: July 2023

The payment system at the Smartindo Tutoring Institute. Although it has used a web-based system that is integrated with the academic system, the existing system has not been able to run properly. So, it is forced to make adjustments in the business processes of payment section. System changes are carried out using the BPR (Business Process Reengineering) method so that the system change process can be in accordance with the needs and is able to transform conventional systems into digital systems by reducing unnecessary steps. The aim of this research is to produce a new payment system based on process optimization using the BPR method. There are 4 stages of BPR that will be carried out in this research including identify processes, review update analyze as-is, design to-be, test & implement to-be. The results of these system changes resulted in a new system that showed a better level of throughput efficiency. The old system has been identified only has a throughput efficiency value of 48.39%. After analyzing and making changes to the process, the new system produces a better level of efficiency, reaching 100%. The results of better efficiency cannot be separated from the success in reducing the stages that are considered no longer needed in the workflow of the new payment system.
Pengembangan Sistem ERP Modul Inventory Management Pada Kantor Perwakilan PT. BGA Group
Authors: Prasetyaningrum Eka , Setyawan Benny 
Published: July 2023

Memasuki era industry 4.0, perusahaan dituntut untuk dapat bertahan dengan segala macam resiko yang dihadapi. PT. Bumitama Gunajaya Agro Group merupakan salah satu perusahaan perkebunan dan pabrik kelapa sawit di Kalimantan Tengah. PT. BGA Group memiliki kantor perwakilan yang berada di Kota Sampit. Dalam pengelolaan inventory barang pada Kantor Perwakilan di PT. BGA Group telah terkomputerisasi tetapi belum terintegrasi dengan baik. Untuk pendataan permintaan barang dari kebun, pendataan vendor, barang masuk dan keluar, serta pengiriman barang masih harus didata satu persatu kedalam Microsoft Excel. Oleh karena itu diperlukan adanya sebuah sistem yang dapat mempermudah karyawan dalam melakukan permintaan, pencatatan bahkan pencarian data yang dibutuhkan, sehingga ERP modul Inventory dapat menjadi sebuah solusi. Untuk metode pengembangan sistem menggunakan metode Agile dengan pengujian Black Box. Berdasarkan hasil pengujian maka dengan adanya sistem inventory dapat membuat pekerjaan menjadi lebih mudah dan mampu mempersingkat waktu dalam proses pengelolaan data perusahaan.
Progression of Decomposed Local-Effect Action Theories
Authors: Soutchanski Mikhail 
Published: July 2023

<p>In many tasks related to reasoning about consequences of a logical theory, it is desirable to decompose the theory into a number of weakly related or independent components. However, a theory may represent knowledge that is subject to change, as a result of executing actions that have effects on some of the initial properties mentioned in the theory. Having once computed a decomposition of a theory, it is advantageous to know whether a decomposition has to be computed again in the newly changed theory (obtained from taking into account changes resulting from execution of an action). In this article, we address this problem in the scope of the situation calculus, where a change of an initial theory is related to the notion of progression. Progression provides a form of forward reasoning; it relies on forgetting values of those properties, which are subject to change, and computing new values for them. We consider decomposability and inseparability, two component properties known from the literature, and contribute by studying the conditions (1) when these properties are preserved and (2) when they are lost wrt progression and the related operation of forgetting. To show the latter, we demonstrate the boundaries using a number of negative examples. To show the former, we identify cases when these properties are preserved under forgetting and progression of initial theories in local-effect basic action theories of the situation calculus. Our article contributes to bridging two different communities in knowledge representation, namely, research on modularity and research on reasoning about actions. </p>
TAX AVOIDANCE PADA PERUSAHAAN SEKTOR PERTAMBANGAN DI INDONESIA.
Authors: Dayani Luluk , Suryandari Dhini 
Published: July 2023

Penelitian ini bertujuan untuk melakukan pengujian secara empiris pengaruh Corporate Social Responsibility (CSR), leverage, dan profitabilitas terhadap tax avoidance. Populasi yang digunakan pada penelitian ini adalah perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) selama tahun 2016-2020. Pengambilan sampel menggunakan teknik purposive sampling sehingga menghasilkan jumlah sampel sebanyak 10 perusahaan dengan total unit analisis sebanyak 50. Teknik pengumpulan data dalam penelitian ini menggunakan teknik dokumentasi. Data yang diperoleh bersumber dari www.idx.co.id atau website resmi masing-masing sampel perusahaan. Analisis data menggunakan regresi linier berganda dengan program komputer Microsoft Excel dan SPSS versi 24. Hasil penelitian ini membuktikan CSR tidak berpengaruh terhadap tax avoidance, leverage berpengaruh negatif siginifikan terhadap tax avoidance, sedangkan profitabilitas berpengaruh positif signifikan terhadap tax avoidance. Berdasarkan hasil penelitian dapat disimpulkan bahwa tax avoidance dapat dipengaruhi oleh leverage dan profitabilitas.
Kata Kunci: Corporate Social Responsibility (CSR), Profitabilitas, Leverage, Tax Avoidance.
Species list and pictorial key to the dung beetles (Coleoptera, Scarabaeidae, Scarabaeinae) in the Chinnar Wildlife Sanctuary in the south Western Ghats, India
Authors: Sobhana K.A. , Sabu Thomas K. 
Published: July 2023

Thirty five species comprising 13 genera were recorded from the thorny forests in Chinnar Wildlife Sanctuary, Kerala, India. Genera Onthophagus (14 species) and Caccobius (six species) were the most specious in the region. Pictorial key to the dung beetles in the thorny forest of Chinnar Wildlife Sanctuary collected during 2010-2015 is given.
Compatibility of carbosulfan 25 EC with certain agrochemicals in brinjal ecosystem
Authors: Kamala I. Merlin , Chandrasekaran S. 
Published: July 2023

The combined use of chemical insecticides with fungicides and fertilizers in a single application is a promising pest-control option to maximise productivity and minimize labour efficiency. Studies were conducted to assess the compatibility of systemic insecticide, carbosulfan 25 EC with a fungicide, micronutrient and insecticide in brinjal ecosystem. The optimum and effective dose of carbosulfan (250 g a.i.ha-1) was compatible with other agro chemicals used in combination viz., copper oxy chloride 50 WP @500 g a.i.ha-1, zinc sulphate 0.5 per cent and dimethoate 30 EC @ 300 g a.i.ha-1, without any creaming matter and/or sediment formation in any of the combinations. The tank mix foliar application of the combination chemicals viz., carbosulfan @ 250 g a.i.ha-1 + copper oxy chloride 50 WP @ 500 g a.i.ha-1, carbosulfan @ 250 g a.i.ha-1 + zinc sulphate 0.5 per cent and carbosulfan @ 250 g a.i.ha-1 + dimethoate @ 300 g a.i.ha-1 did not inflict any phytotoxic effect on the treatment imposed plants and a mean grade of ‘1’ (0-10% injury) was awarded to all the treated plants in the brinjal ecosystem. The bioefficacy trials after two rounds of spraying with carbosulfan and combination with fertilizer and fungicides revealed that maximum per cent reduction is noticed in insecticide combination (carbosulfan @ 250 g a.i.ha-1 + dimethoate @ 300 g a.i.ha-1) as well as recommended and four times the dose of carbosulfan (250 and 1000 g a.i.ha-1), which similarly effects in managing the shoot and fruit damage caused by the shoot and fruit borer, Leucinodes orbonalis. The treatments with fertilizer and fungicides alone marked the least reduction in fruit and shoot damage. The yield of brinjal ranged from 24.1to 28.7 t ha-1 in different treatments. Plots treated with carbosulfan @ 250 g a.i.ha-1 + dimethoate @ 300 g a.i.ha-1recorded the highest fruit yield (28.7 t ha-1) followed by carbosulfan @ 250 g a.i.ha-1 + copper oxy chloride @ 500 g a.i.ha-1 (28.3 t ha-1) and carbosulfan @ 250 g a.i.ha-1+ zinc sulphate (27.8 t ha-1). The current findings states that carbosulfan in combination with other agrochemicals have given better results in terms of phytotoxicity, bioefficacy and yield.
A review of Macromia Rambur, 1842 (Odonata, Macromiidae) of Western Ghats, with taxonomic notes on Macromia miniata Fraser, 1924 and M. irata Fraser, 1924
Authors: Sadasivan Kalesh , Nair Vinayan P. , Samuel K. Abraham 
Published: July 2023

A review of the genus Macromia Rambur, 1842 (Odonata, Macromiidae) of Western Ghats of Peninsular India is presented with its updated distribution. An attempt is made to collate the scattered data in peer-reviewed literature published to date and is supplemented with field data gathered by the authors over two decades. Although Macromia is represented by nine species including six endemics in the Western Ghats, not much has been published on them from the region. Macromia irata Fraser, 1924 was described from Coorg but was rarely reported in peer-reviewed literature since its very brief original description by Fraser in 1924. The detailed morphology including that of the genitalia of M. irata is discussed. A revised classification based on the species groups and a key to the species of Macromia of the Western Ghats of Peninsular India is provided. To quantify the ratios of the number of the prenodal and postnodal veins in Odonata, a new nodal range expression called Standardised Species Nodal Range (SSNR) and a new index termed Standardised Species Nodal Index (SSNI) is also proposed.
Protección y conservación del patrimonio cultural desde una gestión sostenible
Authors: Sánchez-Clemente Ramos Andrés 
Published: July 2023

En 2015 se celebró la Cumbre de las Naciones Unidas Sobre el Desarrollo Sostenible. En esa cumbre se aprobó el plan más ambicioso en materia de sostenibilidad hasta la fecha; el plan recibe el nombre Transformar nuestro mundo: la Agenda 2030 para el Desarrollo Sostenible. Desde entonces el desarrollo sostenible es un término común en nuestras vidas. Pero, ¿qué significado tiene en el ámbito del patrimonio cultural? ¿El patrimonio cultural está contemplado en los ODS de la Agenda 2030 para el Desarrollo Sostenible?
Desarrollo sostenible aquel que satisface las necesidades del presente sin comprometer la capacidad de las futuras generaciones para satisfacer las propias. Con tal propósito se establecieron los 17 ODS y las 169 metas. Si bien los ODS son ambiciosos, el patrimonio cultural no está contemplado en los mismos pero sí en las metas.
Los bienes culturales son limitados, irremplazables y su deterioro o destrucción supondría un empobrecimiento cultural y social. Para garantizar la protección de un bien patrimonial este debe poseer un uso aunque haya variado del original. Un uso actual y social del patrimonio es el turismo cultural. Este favorece el conocimiento de los bienes culturales pero hay evidencias de que el uso turístico masificado de los bienes culturales causa graves deterioros en estos. Las evaluaciones de impacto patrimonial y los planes de conservación preventiva son dos herramientas empleadas en la gestión del patrimonio que nos permiten emplear y disfrutar los bienes culturales sin deteriorarlos ni ponerlos en peligro para las generaciones futuras.
Studi Komparasi Prosedur Olah Gerak Kapal Manual dan Digital (Penerapan Website UPP Kelas III Batang)
Authors: Rosita Niken Devi , Saputri Hanasti Asyifaa 
Published: July 2023

Proses olah gerak kapal merupakan salah satu kegiatan kapal dalam melaksanakan operasional di area pelabuhan. Penerapan olah gerak secara manual mengalami kendala terkait personel yang berwenang pada saat legalisasi dokumen sehingga adanya sistem perizinan secara digital melalui website UPP kelas III Batang digalakkan untuk mempermudah kegiatan operasional kapal. Website yang digunakan pada sistem digitalisasi perizinan ini di bawah naungan Kementerian Perhubungan. Metode penelitian yang digunakan menggunakan penelitian deskriptif komparatif untuk membandingkan dua atau lebih situasi dengan teknik pengumpulan data dalam bentuk studi pustaka, studi dokumen, observasi serta wawancara tidak terstruktur. Objek dalam penelitian ini yaitu kegiatan olah gerak Tug Boat. LLB sukses 22 pada kurun waktu November 2021. Tujuan penelitian ini untuk mengetahui perbandingan perizinan olah gerak manual dan menggunakan sistem digital serta kendala di lapangan terkait 2 metode di atas. Hasil dari penelitian menunjukkan bahwa penerapan prosedur perizinan olah gerak kapal melalui website berjalan efektif dan mendukung kelancaran kegiatan operasional kapal.
ANALISIS PENGARUH STRES KERJA, BEBAN KERJA DAN LINGKUNGAN KERJA TERHADAP TURNOVER INTENTION KARYAWAN PADA YAYASAN PENDIDIKAN BHAKTI SUCI PURWODADI KABUPATEN GROBOGAN
Authors: Sarbullah Sarbullah , Putri Egiliana Atika 
Published: July 2023

the purpose of this study was to determine the effect of work stress, workload, and work environment on employee turnover intention at the Bhakti Suci Education Foundation. High employee turnover rates result in organizations becoming ineffective, losing experienced employees and needing to train new employees. high work stress and a good work environment will affect the decrease in the level of turnover intention, while a high workload will affect the increase in turnover intention.
The population in this study were all employees of the Bhakti Suci Purwodadi Education Foundation, Grobogan Regency, with a sample of 60 respondents. The sampling technique in this study was a saturated sample or census sample, where all members of the population were sampled.
Results of data analysis For the classical assumption test as a whole the data is normally distributed. The results of the t-test in this study indicate that the work stress variable (X1) has a partial effect on turnover intention with a significant value of 0.742, workload variable (X2) has a partial or separate effect on employee turnover intention with a significant value of 0.00. Work environment variable (X3) has a partial or separate effect on employee turnover intention with a significant value of 0.035.
Genomic characterization of Pantoea anthophila strain UI705 causing urinary tract infections in China
Authors: Zhang Yingmiao , Fan Yue , Zhan Yu , Wang Hao , Li Xun , Wang Hui , Feng Tian , Shi Lifeng , Wang Jing , Wang Hui , Lu Zhongxin 
Published: July 2023

IntroductionPantoea anthophila (P. anthophila) is a Gram-negative bacterium initially isolated from Impatiens balsamina in India. P. anthophila has been characterized with low pathogenicity, and no human infections caused by this organism have been reported yet. We report the first case of urinary tract infection caused by P. anthophila in a 73-year-old man after bladder cancer surgery.MethodsThe bacterial isolate gained from urine was named UI705 and identified as P. anthophila by MALDI-TOF mass spectrometry. The genome sequencing and analysis were performed to further characterize the pathogenesis of the clinical isolate.Result and discussionTo the best of our knowledge, this is the first report of human infection caused by P. anthophila in China. The draft genome sequence of P. anthophila UI705 provides a fundamental resource for subsequent investigation of its virulence factors, antibiotic resistance, host–pathogen interactions, and comparative genomics of genus Pantoea.
How media pluralism navigates ideological orientations: the case of Slovenia
Authors: Valič Tamara Besednjak , Rončević Borut , Tomšič Matevž 
Published: July 2023

IntroductionMedia and its reporting shape public opinion, and doing this can obtain an indirect and significant influence on the course and results of the political process. In this context, media operates as an active element of the political process.MethodsThe authors use the Janis-Fadner coefficient of imbalance to analyze a total of 1434 media texts published in 10 different Slovenian media outlets. The texts were published between March and September 2020.ResultsThe authors discover weak media plurality as the main characteristic of the Slovenian media space. The results show the majority of media reporting is strongly anti-right-wing-governmental and left-wing oriented with little pluralism. Most news coverage of web portals demonstrates a distinct ideological note, resulting in predominant expressions of centre-left and anti-center-right government views.DiscussionMost analyzed media is significantly more unfavorable to the center-right government than the center-left opposition, taking a notable left-wing stance. Confirmed by previous conducted studies, the Slovenia's political left seems to have much stronger media support than its right-wing counterpart. For the purpose, would be important to observe whether demonstrated harsh anti-government and pro-opposition orientation changed following the establishment of a new left-wing government after April 2020 elections.