bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and Prospects of All‐Solid‐State Electrodes for Solid‐State Lithium Batteries
Authors: Dong Shaowen , Sheng Li , Wang Li , Liang Jie , Zhang Hao , Chen Zonghai , Xu Hong , He Xiangming 
Published: August 2023

AbstractIn the development of all‐solid‐state lithium batteries (ASSLB), progress is made with solid‐state electrolytes; however, challenges regarding compatibility and stability still exist with solid electrodes. These issues result in a low battery capacity and short cycle life, which limit the commercial application of ASSLBs. This review summarizes the recent research progress on solid‐state electrodes in ASSLBs including the solid–solid interface phenomena such as the interface between electrode materials and electrolytes. The mechanical stability problems in solid electrodes, including fracture, brittleness, and deformation of electrode materials, are also discussed, and corresponding methods to measure the solid electrode stress are provided. In addition, strategies for mitigating stress‐related issues are examined. Finally, the fabrication process of solid electrodes is introduced and their future developments, including the exploration of new electrode materials and the design of more intelligent electrode structures, are proposed.
Light‐Induced Electron Transfer Toward On/Off Room Temperature Phosphorescence in Two Photochromic Coordination Polymers
Authors: Feng Dong‐Xue , Mu Ying , Li Jie , De Han Song‐ , Li Jin‐Hua , Sun Hui‐Li , Pan Mei , Hu Ji‐Xiang , Wang Guo‐Ming 
Published: August 2023

AbstractPhotoswitchable room temperature phosphorescence (RTP) materials are of great interest due to their potential applications in optical devices and switches. Herein, two Zn‐based coordination polymers (CPs) (H3‐TPB)·[Zn6(H‐HEDP)(HEDP)3(H2O)2]·5H2O (complex 1; HEDP = hydroxyethylidene diphosphonate; TPB = 1,3,5‐tris(4‐pyridyl)benzene) and (H‐TPB)·[Zn3(H‐HEDP)(HEDP)(H2O)]·2H2O (complex 2) with distinguishable photochromism and tunable RTP are synthesized involving photoactive TPB molecules with different packing modes. Complex 1 exhibits bidirectionally on/off RTP regulation via on‐switch with excitation of 250−330 nm light and off‐switch with 350−380 nm, and the “turn‐on” behavior can be attributed to the advance of Förster resonance energy transfer‐assisted intersystem crossing (ISC) process while “turn‐off” process due to the transformation from H3‐TPB cations to H3‐TPB· radicals. Complex 2 exhibits photoswitchable RTP accompanied with reversible photochromism by leveraging the self‐absorption and RTP emission. Two demos based on the above compounds are further applied to demonstrate the application in information recording and encryption fields. This work supplies a strategy toward the design of switchable RTP systems using electron transfer photochromism, shedding light on broadening the frontiers of photoresponsive materials.
Tumor Shape‐Specific Brachytherapy Implants by 3D‐Printing, Precision Radioactivity Painting, and Biomedical Imaging
Authors: Lescot Théophraste , Lebel‐Cormier Marie‐Anne , Seniwal Baljeet , Gros‐Louis Philippe , Bellerive Claudine , Landreville Solange , Beaulieu Luc , Fortin Marc‐André 
Published: August 2023

AbstractIn brachytherapy (BT), or internal radiation therapy, cancer is treated by radioactive implants. For instance, episcleral plaques (EPs) for the treatment of uveal melanoma, are designed according to generic population approximations. However, more personalized implants can enhance treatment precision through better adjustment of dose profiles to the contours of cancerous tissues. An original approach integrating biomedical imaging, 3D printing, radioactivity painting, and biomedical imaging, is developed as a workflow for the development of tumor shape‐specific BT implants. First, computer‐aided design plans of EP are prepared according to guidelines prescribed by the Collaborative Ocular Melanoma Study protocol. Polyetheretherketone (PEEK), a high‐performance polymer suitable for permanent implants, is used to 3D‐print plaques and the geometrical accuracy of the printed design is evaluated by imaging. The possibility to modulate the dose distribution in a tridimensional manner is demonstrated by painting the inner surfaces of the EPs with radioactive 103Pd, followed by dose profile measurements. The possibility to modulate dose distributions generated by these 3D‐printed plaques through radioactivity painting is therefore confirmed. Ex vivo surgical tests on human eyeballs are performed as an assessment of manipulation ease. Overall, this work provides a solution for the fabrication of tumor‐specific radioactive implants requiring higher dose precision.
High Entropy Nonlinear Dielectrics with Superior Thermally Stable Performance
Authors: Wang Yong‐Jyun , Lai Hung‐Chi , Chen Yu‐Ang , Huang Rong , Hsin Ti , Liu Heng‐Jui , Zhu Ruixue , Gao Peng , Li Cong , Yu Pu , Chen Yi‐Chun , Li Jiangyu , Chen Yi‐Cheng , Yeh Jien‐Wei , Chu Ying‐Hao 
Published: August 2023

AbstractA high configurational entropy, achieved through a proper design of compositions, can minimize the Gibbs free energy and stabilize the quasi‐equilibrium phases in a solid‐solution form. This leads to the development of high‐entropy materials with unique structural characteristics and excellent performance, which otherwise could not be achieved through conventional pathways. This work develops a high‐entropy nonlinear dielectric system, based on the expansion of lead magnesium niobate–lead titanate. A dense and uniform distribution of nano‐polar regions is observed in the samples owing to the addition of Ba, Hf, and Zr ions, which lead to enhanced performance of nonlinear dielectrics. The fact that no structural phase transformation is detected up to 250 °C, and no noticeable change or a steep drop in structural and electrical characteristics is observed at high temperatures suggests a robust thermal stability of the dielectric systems developed. With these advantages, these materials hold vast potential for applications such as dielectric energy storage, dielectric tunability, and electrocaloric effect. Thus, this work offers a new high‐entropy configuration with elemental modulation, with enhanced dielectric material features.
Patchy Bubble‐Propelled Colloids at Interfaces
Authors: Rivas David P. , Sokolich Max , Muller Harrison , Das Sambeeta 
Published: August 2023

AbstractLiquid–liquid or liquid–air interfaces provide interesting environments to study colloids and are ubiquitous in nature and industry, as well as relevant in applications involving emulsions and foams. They present a particularly intriguing environment for studying active particles which exhibit a host of phenomena not seen in passive systems. Active particles can also provide on‐demand controllability that greatly expands their use in future applications. However, research on active particles at interfaces is relatively rare compared to those at solid surfaces or in the bulk. Here, magnetically steerable active colloids at liquid–air interfaces that self‐propel by bubble production via the catalytic decomposition of chemical fuel in the liquid medium is presented. The bubble formation and dynamics of “patchy” colloids with a patch of catalytic coating on their surface is investigated and compared to more traditional Janus colloids with a hemispherical coating. The patchy colloids tend to produce smaller bubbles and undergo smoother motion which makes them beneficial for applications such as precise micro‐manipulation. This is demonstrated by manipulating and assembling patterns of passive spheres on a substrate as well as at an air–liquid interface. The propulsion and bubble formation of both the Janus and patchy colloids is characterized and it is found that previously proposed theories are insufficient to fully describe their motion and bubble bursting mechanism. Additionally, the colloids, which reside at the air–liquid interface, demonstrate novel interfacial positive gravitaxis towards the droplet edges which is attributed to a torque resulting from opposing downward and buoyant forces on the colloids.
A Simple and Fast Compression‐Based Method to Fabricate Responsive Gold‐pNIPAM Hybrid Materials: From Thin Films to Anisotropic Microgels
Authors: Sepúlveda Adolfo , Feller Déborah , Karg Matthias , Boudreau Denis 
Published: August 2023

AbstractIn recent years, hydrogel‐based soft materials with hybrid properties have found widespread use in various technological fields, including tissue engineering, soft actuators, and flexible electronics. The proper implementation of these smart multifunctional materials into real‐world applications requires the development of simple, cost‐effective, and large‐scale fabrication methods. Herein, a simple compression‐ and colloid‐based method is presented to fabricate responsive Au‐poly(N‐isopropylacrylamide) (pNIPAM) hybrid films using photopolymerizable resin containing Au‐pNIPAM core–shell microgels as building blocks. Uniform Au‐pNIPAM hybrid films of 25 × 25 mm with adjustable thickness in the micron‐size range (2.3–1.2 µm) w ere successfully fabricated on glass substrates and flexible commercial acetate sheets. The resulting flexible Au‐pNIPAM films exhibit robust optical and mechanical properties, even after repeated edge‐to‐edge bending cycle tests. Additionally, using patterned light to polymerize the Au‐pNIPAM films allows synthesizing of anisotropic Au‐pNIPAM microgels with high width‐to‐height aspect ratios, such as square, circular, and rectangular microgels, adding a new dimension to the proposed fabrication method.
Easy Approach to Graphene Growth on Ir(111) and Ru(0001) from Liquid Ethanol
Authors: Dedkov Yuriy , Zhou Junhao , Guo Yefei , Voloshina Elena 
Published: August 2023

AbstractThe growth of a high‐quality complete graphene layer is successfully achieved for Ir(111) and Ru(0001) substrates using liquid ethanol as a precursor. Metallic substrates, which are cleaned in ultra‐high vacuum conditions, were ex‐situ immersed in liquid ethanol followed by the controlled in situ thermal annealing. The process of graphene formation and its quality are carefully monitored using X‐ray photoelectron spectroscopy, low‐energy electron diffraction, and scanning tunneling microscopy methods. It is found that graphene formation starts at 400 °C via ethanol decomposition and desorption of oxygen from the surface leading to the formation of the high‐quality complete graphene layer at 1000 °C. The results of the systematic angular‐resolved photoelectron spectroscopy experiments confirm the high quality of the obtained graphene layer, and it concludes that such an approach offers an easy, quick, and reproducible method to synthesize large‐scale graphene on different metallic substrates.
Origin of the Memory Effect in Electrochromic Sputtered WO3 Films: Composition, Structure, or Morphology?
Authors: Faceira Brandon , Teulé‐Gay Lionel , Le Hébel Jade , Labrugère‐Sarroste Christine , Ibalot Fabienne , Huang Hou‐Yi , Huang Yu‐Cheng , Dong Chung‐Li , Salvetat Jean‐Paul , Maglione Mario , Rougier Aline 
Published: August 2023

AbstractThe memory effect property, described as a reversible color persistence while the potential is withdrawn, is of particular importance to reaching zero‐energy consumption electrochromic devices. Nevertheless, often observed in organic materials, it is poorly studied in oxides. In this study, electrochromic tungsten oxide thin films are elaborated at different working pressures by radiofrequency magnetron sputtering. The influence of the deposition pressure on the electrochemical properties of WO3 films as well as on their memory effect is investigated. Three kinds of WO3 films can be distinguished: with irreversible blue coloration, with reversible coloration presenting a high memory effect, and with reversible coloration with a low memory effect. The origin of these discrepancies is studied through the composition, the local atomic environment, and the morphology of the WO3 thin films. An increase of transmittance at 550 nm as low as 15.8% in 48 h in air and 5.2% in 24 h in the electrolyte is recorded. This study highlights a better understanding of the memory effect property of electrochromic oxides for low‐consumption energy electrochromic devices, pointing out morphology as a key parameter.
Plasmon‐Assisted Directional Infrared Photoluminescence of HgTe Nanocrystals
Authors: Bossavit Erwan , Dang Tung Huu , He Puyuan , Cavallo Mariarosa , Khalili Adrien , Dabard Corentin , Zhang Huichen , Gacemi Djamal , Silly Mathieu G. , Abadie Claire , Gallas Bruno , Pierucci Debora , Todorov Yanko , Sirtori Carlo , Diroll Benjamin T. , Degiron Aloyse , Lhuillier Emmanuel , Vasanelli Angela 
Published: August 2023

AbstractHgTe nanocrystals offer a unique spectral tunability with both absorption and emission covering the near and mid‐infrared as well as the THz window. Nevertheless, a very limited amount of work is dedicated to electroluminescence from this material. An efficient diode not only requires designing a structure that achieves a high electrical efficiency (i.e., efficient electron and hole injections), but also finding a way to efficiently extract the emitted photons. The shift from visible to infrared certainly demands revisiting the strategies proposed for shorter wavelengths (microlens arrays). Here, a metallic grating is used to enhance the photoluminscence signal up to a factor of 4 while enabling directionality in the emission, which is driven by the grating period.
Three‐Component Radical Cascade Reaction of Quinoxalinones, Alkenes and AgSCF3
Authors: Peng Sha , Xie Long‐Yong , Yang Luo 
Published: August 2023

AbstractA convenient and practical protocol for the preparation of SCF3‐containing quinoxalin‐2(1H)‐one derivatives via K2S2O8 mediated difunctionalization of alkenes with quinoxalinones and AgSCF3 was developed. The preliminary study showed that a SCF3 radical triggered cascade reaction process might be involved in the current transformation.
Programming Injectable DNA Hydrogels Yields Tumor Microenvironment‐Activatable and Immune‐Instructive Depots for Augmented Chemo‐Immunotherapy
Authors: Fan Yu , Zhan Mengsi , Liang Junhao , Yang Xingsen , Zhang Beibei , Shi Xiangyang , Hu Yong 
Published: August 2023

AbstractInjectable hydrogels have attracted increasing attention for promoting systemic antitumor immune response through the co‐delivery of chemotherapeutics and immunomodulators. However, the biosafety and bioactivity of conventional hydrogel depots are often impaired by insufficient possibilities for post‐gelling injection and means for biofunction integration. Here, an unprecedented injectable stimuli‐responsive immunomodulatory depot through programming a super‐soft DNA hydrogel adjuvant is reported. This hydrogel system encoded with adenosine triphosphate aptamers can be intratumorally injected in a gel formulation and then undergoes significant molecular conformation change to stimulate the distinct release kinetics of co‐encapsulated therapeutics. In this scenario, doxorubicin is first released to induce immunogenic cell death that intimately works together with the polymerized cytosine‐phosphate‐guanine oligodeoxynucleotide (CpG ODN) in gel scaffold for effectively recruiting and activating dendritic cells. The polymerized CpG ODN not only enhances tumor immunogenicity but minimizes free CpG‐induced splenomegaly. Furthermore, the subsequently released anti‐programmed cell death protein ligand 1 (aPDL1) blocks the corresponding immune inhibitory checkpoint molecule on tumor cells to sensitize antitumor T‐cell immunity. This work thus contributes to the first proof‐of‐concept demonstration of a programmable super‐soft DNA hydrogel system that perfectly matches the synergistic therapeutic modalities based on chemotherapeutic toxicity, in situ vaccination, and immune checkpoint blockade.
Enantioselective SN2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis
Authors: Li En , Tang Kai , Ren Zhuhui , Liao Xiaoyun , Liu Qianchen , Huang Yong , Chen Jiean 
Published: August 2023

AbstractThe functionalization of the β‐carbon of enals with electrophiles is a signature umpolung reactivity of N‐heterocyclic carbene (NHC) derived homoenolates. However, only a limited number of electrophiles are shown to be compatible, with most of them being π‐electrophiles. In this study, the successful enantioselective β‐alkylation of homoenolates is reported using Csp3 electrophiles through an SN2 strategy. The protocol shows a broad scope regarding alkyl electrophiles, delivering good yields, and excellent enantioselectivities (up to 99% ee). It enables the installation of drug‐like structural motifs in either enals or alkylating agents, demonstrating its potential as a valuable tool for late‐stage modification. Furthermore, a concise synthetic route is presented to chiral pyrroloindoline‐type skeletons. Preliminary mechanistic studies support a direct SN2 mechanism.
Rare earth Eu3+/Tb3+‐doped hollow microspheres (LaPO4) and core‐shell nanocomposite luminescent materials with different transmittance (SiO2@LaPO4 Eu3+) preparation and research on luminescence performance
Authors: Ma Yujie , Wang Xigui , E Namila 
Published: August 2023

AbstractFor the manufacture of hollow nanospheres that had different shapes, three distinct templates—urea, carbon microspheres, and polyethylene glycol 20,000—were used. The relationship between microspheres with various hollow structures and their luminescent properties were investigated. Furthermore, the effects of annealing temperature and the proportion of rare earth Eu3+/Tb3+ions in the reaction were investigated using the structural characteristics of the microspheres and fluorescent materials. The fluorescent materials were wrapped on the outer surface of the microspheres. The ideal balance between the best structure and superior luminescent performance was found, to create reasonably good white light.
MFSD2A potentiates gastric cancer response to anti‐PD‐1 immunotherapy by reprogramming the tumor microenvironment to activate T cell response
Authors: Zhang Bin , Wang Chun‐Mei , Wu Hao‐Xiang , Wang Feng , Chai Yang‐Yang , Hu Ye , Wang Bing‐Jing , Yu Zhou , Xia Rong‐Hua , Xu Rui‐Hua , Cao Xue‐Tao 
Published: August 2023

AbstractBackgroundThe efficacy of anti‐programmed cell death protein 1 (PD‐1) immunotherapy in various cancers, including gastric cancer (GC), needs to be potentiated by more effective targeting to enhance therapeutic efficacy or identifying accurate biomarkers to predict clinical responses. Here, we attempted to identify molecules predicting or/and promoting anti‐PD‐1 therapeutic response in advanced GC (AGC).MethodsThe transcriptome of AGC tissues from patients with different clinical responses to anti‐PD‐1 immunotherapy and GC cells was analyzed by RNA sequencing. The protein and mRNA levels of the major facilitator superfamily domain containing 2A (MFSD2A) in GC cells were assessed via quantitative real‐time polymerase chain reaction, Western blotting, and immunohistochemistry. Additionally, the regulation of anti‐PD‐1 response by MFSD2A was studied in tumor‐bearing mice. Cytometry by Time‐of‐Flight, multiple immunohistochemistry, and flow cytometry assays were used to explore immunological responses. The effects of MFSD2A on lipid metabolism in mice cancer tissue and GC cells was detected by metabolomics.ResultsHigher expression of MFSD2A in tumor tissues of AGC patients was associated with better response to anti‐PD‐1 immunotherapy. Moreover, MFSD2A expression was lower in GC tissues compared to adjacent normal tissues, and its expression was inversely correlated with GC stage. The overexpression of MFSD2A in GC cells enhanced the efficacy of anti‐PD‐1 immunotherapy in vivo by reprogramming the tumor microenvironment (TME), characterized by increased CD8+ T cell activation and reduced its exhaustion. MFSD2A inhibited transforming growth factor β1 (TGFβ1) release from GC cells by suppressing cyclooxygenase 2 (COX2)‐prostaglandin synthesis, which consequently reprogrammed TME to promote anti‐tumor T cell activation.ConclusionsMFSD2A potentially serves as a predictive biomarker for anti‐PD‐1 immunotherapy response in AGC patients. MFSD2A may be a promising therapeutic target to potentiate the efficacy of anti‐PD‐1 immunotherapy by reprogramming the TME to promote T cells activation.
Single‐dose NEPA versus an aprepitant regimen for prevention of chemotherapy‐induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy
Authors: Zelek Laurent , Navari Rudolph , Aapro Matti , Scotté Florian 
Published: August 2023

AbstractIntroductionNon‐inferiority of NEPA (fixed combination of NK1 receptor antagonist (RA), netupitant, and 5‐HT3RA, palonosetron) versus an aprepitant regimen was previously shown in a pragmatic study in patients receiving anthracycline cyclophosphamide (AC) and non‐AC moderately emetogenic chemotherapy (MEC). In the MEC group a numerically higher complete response (CR: no emesis, no rescue) rate was seen for NEPA during the overall 0–120 h phase (NEPA 76.1% vs. 63.1% aprepitant). As NEPA exhibits long‐lasting efficacy, this study evaluated a prolonged period up to 144 h, beyond the traditional 120 h post‐chemotherapy. In this post‐hoc analysis we explore the comparative efficacy of NEPA versus the aprepitant regimen in the MEC group up to 144 h, while also assessing the impact of risk factors on CINV prevention.MethodsThis was a pragmatic, multicenter, randomized, prospective study. Oral NEPA was administered as a single dose on day 1, while aprepitant was given on days 1–3 + ondansetron on day 1; all patients were to receive dexamethasone on days 1–4. Patients were chemotherapy‐naïve and receiving MEC, with a subset evaluation of those with a risk factor for developing CINV (i.e., female, male <60 years, male ≥60 years who received carboplatin, or male ≥60 years with anxiety). CR rates were compared during the extended overall (0–144 h) phase.ResultsThe MEC group included 211 patients; of these 181 were in the risk factor subset. Significantly higher CR rates were seen for NEPA than aprepitant during the extended overall phase for the total MEC group (NEPA 77.1%, aprepitant 57.8%, p = 0.003) and also in the subset of patients with CINV risk factors (NEPA 73.9%, aprepitant 56.2%, p = 0.012).ConclusionA single dose of NEPA, administered on day 1 only, was more effective than a 3‐day aprepitant regimen in preventing CINV for an extended duration in patients receiving MEC and in those with emetic risk factors.