bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of digital business transformation in frugal innovation and SMEs’ resilience in emerging markets
Authors: Al Omoush Khaled , Lassala Carlos , Ribeiro-Navarrete Samuel 
Published: April 2023

PurposeThe present study aims to examine the relationships between digital business transformation, organizational learning, frugal innovation and Small and Medium Enterprises (SMEs) resilience in emerging markets.Design/methodology/approachEmpirical data collection has been implemented using a questionnaire method from 214 owners and managers of SMEs. The partial least squares structural equation modeling (PLS-SEM) approach was used to examine the measurement model and test hypotheses.FindingsThe results show that digital business transformation significantly impacts frugal innovation and SMEs' resilience in emerging markets. They also confirm the significant impact of frugal innovation on SMEs' resilience. Furthermore, the results revealed that organizational learning significantly impacts digital business transformation, frugal innovation and SMEs' resilience.Originality/valueThis study provides novel insights into the existing theories and literature regarding the determinants of SMEs' resilience in emerging markets. It also provides practical contributions, confirming the SMEs' need to develop their dynamic capabilities, including digital transformation, frugal innovation and organizational learning to maintain their resilience.
Effects of interfirm IT capability and interfirm trust on omnichannel integration: the mediating role of interfirm integration
Authors: Li Yang , Huang Xianbao , Zhang Kai 
Published: April 2023

Purpose
Although past studies have suggested that business-to-business (B2B) interfirm relationship management contributes to a firm’s omnichannel integration, little research has been undertaken to reveal how that happens. This study aims to draw upon the relational view to propose a research model that associates interfirm information technology (IT) capability and interfirm trust with omnichannel integration through interfirm integration (i.e. authority integration and cooperative integration). Furthermore, this work considers a firm’s channel usage variety as the boundary condition of the interfirm integration’s influence.

Design/methodology/approach
The research model was examined using a seemingly unrelated regression of archival data and matched a survey of 324 Chinese omnichannel firms.

Findings
Interfirm IT capability positively relates to authority integration, and interfirm trust positively relates to cooperative integration. Authority integration and cooperative integration are both positively associated with omnichannel integration. A high level of channel usage variety strengthens the relationship between cooperative integration and omnichannel integration.

Originality/value
Prior literature has called for research on the factors influencing omnichannel integration within a B2B setting. This study answers this research call by examining interfirm IT capability, interfirm trust and interfirm integration as factors associated with omnichannel integration. This work also examines how channel usage variety regulates the relationship between interfirm integration and omnichannel integration.
Technological capabilities and global value chains: insights from Spanish SMEs in the hotel industry
Authors: Romero Isidoro , Fernández-Serrano José , Cáceres-Carrasco Rafael 
Published: April 2023

PurposeThis study explores the role of international tour operators as the agents assuming the governance and the upgrading of the tourism global value chains (TGVCs), with a special focus on their influence on the development of technological capabilities (TCs) in the hotel industry.Design/methodology/approachThe data used in this article originates from a survey carried out in 2016 on Spanish small and medium-sized hotel companies. An ordinal regression analysis is employed to test the hypotheses proposed in this research.FindingsThis study finds that tour operators exert a positive effect on the technological upgrading process in the hotel industry by stimulating small and medium-sized enterprises (SMEs) to invest in TCs. The causal mechanisms through which these effects take place differ across the various stages of the relationship between hotel companies and tour operators.Practical implicationsThe results have implications both for hotel management in terms of how hotels take advantage of technological upgrading to become more competitive, and for public administrations in terms of what measures can boost the development of hotel TCs in order to increase their added value.Originality/valueTo date, very few studies have analysed the tourism sector based on the influence on the development of TCs of SME hotels by combining GVC concepts and the resource-based view. It is also the first time that the causal mechanisms are shown to explain such influences.
Urban tourists' intention towards visiting national parks: an exertion of theory of planned behaviour and expectancy theory
Authors: Al Rousan Ramzi , Siddiqui Samiha , Bano Naseem , Sujood  
Published: April 2023

PurposeThis study aims to evaluate the key factors affecting the behavioural intention of urban tourists towards visiting national parks by integrating the theory of planned behaviour (TPB) and expectancy theory (ET).Design/methodology/approachData were collected from urban tourists using an online questionnaire developed through Google forms. A total of 489 valid online questionnaires were considered for this study. The proposed research model was empirically evaluated using the structural equation modelling method.FindingsAccording to the results of this research, TPB constructs are significantly and positively associated with the behavioural intention of urban tourists towards visiting national parks in India and out of ET constructs, only expectancy and valence are significantly and positively associated with behavioural intention while instrumentality does not.Research limitations/implicationsThis study manifests the behaviour of urban tourists towards national parks and contributes to academics by incorporating existing literature. The findings of this study also help policymakers in formulating innovative strategies for national parks. It presents an integrated framework that lays the platform for a new study domain on urban tourists' intentions to visit national parks, which will be useful to urban managers, officials and the tourism sector. Furthermore, as the scope of this study is confined to assessing the intentions of urban tourists toward visiting national parks, it is difficult to generalize the findings.Originality/valueTo the best of the authors' knowledge, this is the first research of its kind to provide an understanding of the behavioural intention of urban tourists towards visiting the national parks in India by optimizing the TPB and ET.
The practice of incident reporting and management: current challenges and opportunities for mental health trusts in England
Authors: Wood David , Robinson Catherine , Nathan Rajan , McPhillips Rebecca 
Published: April 2023

PurposeNew patient safety frameworks are being implemented to improve the impact of incident reporting and management across the National Health Service (NHS) in England. This study aims to examine the current practices in this domain of patient safety in a sample of mental health trusts, a setting in which limitations in the current practice of serious incident management have been reported. The authors present key recommendations to maximise the opportunities to improve current incident reporting and management practice.Design/methodology/approachEthical approval for the study was granted. A Web-based questionnaire was designed to examine current practices concerning incident reporting and management. It was refined based on consultation. Patient safety incident managers within mental health trusts in England were recruited. Twenty-nine mental health trusts responded, from a total of 51. The questionnaire study data were analysed in Statistical Package for the Social Sciences.FindingsCurrent approaches used to report and manage incidents have been established and variation in practice demonstrated. A key finding for attention is that the training and education that investigators of serious incidents receive falls short of the recommended minimum national standard of 15 h, with a sample mean of 10.3 h and median of 8.0 h.Originality/valueRecommendations at a local and national level are presented, which, if implemented, can maximise the impact of incident reporting and management practices in mental health trusts. Future qualitative research is indicated, to understand the perceptual experience and meaning behind the findings across a wider group of stakeholders.
The role of inclusive leadership in fostering organisational learning behaviour
Authors: Nejati Mehran , Shafaei Azadeh 
Published: April 2023

Purpose
Organisational learning is fundamental in establishing a fearless organisation, creating a competitive advantage and maintaining a sustained growth. While research suggests that leaders can influence organisational learning, there is currently no empirical evidence on how inclusive leadership fosters organisational learning behaviour. Therefore, the purpose of this study is to investigate the relationship between inclusive leadership and organisational learning behaviour. It also seeks to explore the mediating role of psychological safety and climate for initiatives in the mentioned relationship.

Design/methodology/approach
The study used a two-wave quantitative examination with 317 respondents. Online survey was used to collect data from randomly selected full-time Australian employees in two times. The data were then analysed using partial least squares structural equation modelling to provide insights.

Findings
The study found empirical evidence on the positive association of inclusive leadership and organisational learning behaviour. Moreover, the two mediation paths of psychological safety and climate for initiative were supported for the relationship between inclusive leadership and organisational learning behaviour.

Research limitations/implications
The current study contributes to theory by examining the role of inclusive leadership on organisational learning behaviour through two relatively unexplored mediating paths. It suggests how inclusive leadership can create a fearless organisation through fostering learning behaviour within the organisation which empowers organisations to sustain growth. Despite controlling for and assessing endogeneity, due to the cross-sectional design of the study, it is limited in demonstrating causal links.

Originality/value
The current study provides empirical evidence on the role of inclusive leadership in fostering organisational learning behaviour through two mediating paths of psychological safety and climate for initiatives. The proposed model sets the ground for future research to further develop insights on positive impacts of inclusive leadership within organisations.
Routine placental histopathology findings from women testing positive for SARS‐CoV‐2 during pregnancy: Retrospective cohort comparative study
Authors: Colley Charlotte S. , Hutchinson J. Ciaran , Whitten Sara M. , Siassakos Dimitrios , Sebire Neil J. , Hillman Sara L. 
Published: April 2023

AbstractObjectiveTo assess the impact of maternal Coronavirus disease 2019 (COVID‐19) infection on placental histopathological findings in an unselected population and evaluate the potential effect on the fetus, including the possibility of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).DesignRetrospective cohort comparative study of placental histopathological findings in patients with COVID‐19, compared with controls.SettingDuring the COVID‐19 pandemic, placentas were studied from women at University College Hospital London who reported and/or tested positive for COVID‐19.PopulationOf 10 508 deliveries, 369 (3.5%) women had COVID‐19 during pregnancy, with placental histopathology available for 244 women.MethodsRetrospective review of maternal and neonatal characteristics, where placental analysis had been performed. This was compared with available, previously published, histopathological findings from placentas of unselected women.Main outcome measuresFrequency of placental histopathological findings and relevant clinical outcomes.ResultsHistological abnormalities were reported in 117 of 244 (47.95%) cases, with the most common diagnosis being ascending maternal genital tract infection. There was no statistically significant difference in the frequency of most abnormalities compared with controls. There were four cases of COVID‐19 placentitis (1.52%, 95% CI 0.04%–3.00%) and one possible congenital infection, with placental findings of acute maternal genital tract infection. The rate of fetal vascular malperfusion (FVM), at 4.5%, was higher compared with controls (p = 0.00044).ConclusionsIn most cases, placentas from pregnant women infected with SARS‐CoV‐2 virus do not show a significantly increased frequency of pathology. Evidence for transplacental transmission of SARS‐CoV‐2 is lacking from this cohort. There is a need for further study into the association between FVM, infection and diabetes.
Preventing selfie‐related incidents: Taking a public health approach to reduce unnecessary burden on emergency medicine services
Authors: Cornell Samuel , Brander Robert W , Peden Amy E 
Published: April 2023

AbstractUnintentional deaths from selfies have received limited exposure in emergency medicine literature; yet trauma remains the leading cause of death and disability in children and young adults, and most of those implicated in a selfie incident are in this demographic. Selfie‐related injuries and deaths may be a relatively new phenomenon, but data suggest they are a public health hazard that is not going away. Emergency medicine practitioners may have a role to play in the primary and secondary prevention of selfie incidents, including delivering opportunistic behaviour change messaging to those who are at risk of being injured or killed in a selfie‐related incident, particularly young (14–25 years) males. Emergency medicine specialists should be aware of the dangers of selfie‐related incidents and understand their polytraumatic presentation.
Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena
Authors: AlAnazi Faisal Holil , Al‐kuraishy Hayder M. , Al‐Gareeb Ali I. , Alexiou Athanasios , Papadakis Marios , Ogaly Hanan A. , Alanazi Yousef Abud , Saad Hebatallah M. , Batiha Gaber El‐Saber 
Published: April 2023

AbstractNeprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates various peptide hormones including glucagon‐like peptide 1 (GLP‐1). NEP inhibitors may be effective in the management of type 2 diabetes mellitus (T2DM) by increasing the circulating level of GLP‐1. However, acute‐effect NEP inhibitors may lead to detrimental effects by increasing blood glucose independent of GLP‐1. These findings suggest a controversial point regarding the potential role of NEP inhibitors on glucose homeostasis in T2DM patients. Therefore, this perspective aimed to clarify the controversial points concerning the role of NEP inhibitors on glucose homeostasis in T2DM. NEP inhibitors may lead to beneficial effects by inhibition of NEP, which is involved in the impairment of glucose homeostasis through modulation of insulin resistance. NEP increases dipeptidyl peptidase‐4 (DPP4) activity and contributes to increasing active GLP‐1 proteolysis so NEP inhibitors may improve glycemic control through increasing endogenous GLP‐1 activity and reduction of DPP4 activity. Thus, NEP inhibitors could be effective alone or in combination with antidiabetic agents in treating T2DM patients. However, long‐term and short‐term effects of NEP inhibitors may lead to a detrimental effect on insulin sensitivity and glucose homeostasis through different mechanisms including augmentation of substrates and pancreatic amyloid deposition. These findings are confirmed in animal but not in humans. In conclusion, NEP inhibitors produce beneficial rather than detrimental effects on glucose homeostasis and insulin sensitivity in humans though most of the detrimental effects of NEP inhibitors are confirmed in animal studies.
Foreign direct investments and the dynamics of trade and capital flows: Schumpeterian insights for sustained development
Authors: Kaczmarczyk Patrick , Flassbeck Heiner 
Published: April 2023

AbstractThis article analyses the role of foreign direct investment (FDI) in trade and development theory and outlines the resulting implications for economic policy. We propose an alternative model of international trade and development based on absolute, not comparative advantages of firms, which are nested in countries but compete internationally. Applying a Schumpeterian theory of dynamic development, we consider how firms can either increase their competitiveness through productivity gains at a given wage level, or by combining the existing high level of productivity with lower wages in low‐income countries. We argue that the aim of competition policy must be to improve the quality of economic competition in international markets, limit monopoly rents and disincentivise rent‐seeking activities through the mere outsourcing of production. To that end, we propose that economic policy must reinstate rigorous wage bargaining regimes and make FDI subject to wage conditionality, obliging foreign companies to increase their wages in the host economy in line with average national productivity growth and the national inflation target.
Significance of cuproptosis‐related lncRNA signature in LUAD prognosis and immunotherapy: A machine learning approach
Authors: Yang Lihong , Cui Yazhou , Liang Lu , Lin Jianping 
Published: April 2023

AbstractObjectiveCuproptosis‐related genes are closely related to lung adenocarcinoma (LUAD), which can be analyzed via the analysis of long noncoding RNA (lncRNA). To date, the clinical significance and function of cuproptosis‐related lncRNAs are still not well elucidated. Further analysis of cuproptosis‐related prognostic lncRNAs is of great significance for the treatment, diagnosis, and prognosis of LUAD.MethodsIn this study, a multiple machine learning (ML)‐based computational approach was proposed for the identification of the cuproptosis‐related lncRNAs signature (CRlncSig) via comprehensive analysis of cuproptosis, lncRNAs, and clinical characteristics. The proposed approach integrated multiple ML algorithms (least absolute shrinkage and selection operator regression analysis, univariate and multivariate Cox regression) to effectively identify the CRlncSig.ResultsBased on the proposed approach, the CRlncSig was identified from the 3450 cuproptosis‐related lncRNAs, which consist of 13 lncRNAs (CDKN2A‐DT, FAM66C, FAM83A‐AS1, AL359232.1, FRMD6‐AS1, AC027237.4, AC023090.1, AL157888.1, AL627443.3, AC026355.2, AC008957.1, AP000346.1, and GLIS2‐AS1).ConclusionsThe CRlncSig could well predict the prognosis of different LUAD patients, which is different from other clinical features. Moreover, the CRlncSig was proved to be an effective indicator of patient survival via functional characterization analysis, which is relevant to cancer progression and immune infiltration. Furthermore, the results of RT‐PCR assay indicated that the expression level of FAM83A‐AS1 and AC026355.2 in A549 and H1975 cells (LUAD) was significantly higher than that in BEAS‐2B cells (normal lung epithelial).
Citizens in uniform
Authors: Takabvirwa Kathryn 
Published: April 2023

AbstractAmid economic and sociopolitical turmoil in Zimbabwe, police roadblocks proliferated throughout the country, creating sites not only of extraction but also of citizen engagement. These sites show that sociality mediates policing, as police and policed together negotiate the precarities of living in the wake of crisis. Roadblocks are key to the performance of the state as such. Yet this occasions the very stage on which the state's failings are manifested, as officers are rendered highly visible and scrutable on the road—this visibility is central to sociality, in a mechanism of power that relies on enfleshing the system of policing by those through whom the state acts. Whereas conceptualizations of governance in Africa often take people as a corrupting element, here, the peopling of the system is central to its operation. Encounters at roadblocks invite a reconsideration of reified ideals of policing and power in governance, including reified concepts of disciplinary power.
Current management of uveal melanoma: A review
Authors: Bai Haixia , Bosch Jacobus J. , Heindl Ludwig M. 
Published: April 2023

AbstractUveal melanoma is the most frequent primary intraocular cancer in adulthood and is mostly localised to the choroid. It can be treated using radiation therapy, laser therapy, local resection and enucleation, with the best results achieved by combining these procedures. However, up to half of patients develop metastatic disease. There are no efficacious treatment methods for patients in advanced stage or with metastasis. In recent years, several novel treatment modalities aimed at improving tumour control and reducing adverse events have emerged. This review summarises current clinical treatment methods and new therapeutic perspectives for uveal melanoma.
Cortical dopamine D5 receptors regulate neuronal circuit oscillatory activity and memory in rats
Authors: Albeely Abdalla M. , Nolan Caitlin J. , Rasmussen Duncan J. , Bailey Craig D. C. , Perreault Melissa L. 
Published: April 2023

AbstractIntroductionThe dopamine D5 receptor (D5R) shows high expression in cortical regions, yet the role of the receptor in learning and memory remains poorly understood. This study evaluated the impact of prefrontal cortical (PFC) D5R knockdown in rats on learning and memory and assessed the role of the D5R in the regulation of neuronal oscillatory activity and glycogen synthase kinase‐3 (GSK‐3β), processes integral to cognitive function.Materials and MethodsUsing an adeno‐associated viral (AAV) vector, male rats were infused with shRNA to the D5R bilaterally into the PFC. Local field potential recordings were taken from freely moving animals and spectral power and coherence were evaluated in, and between, the PFC, orbitofrontal cortex (OFC), hippocampus (HIP), and thalamus. Animals were then assessed in object recognition, object location, and object in place tasks. The activity of PFC GSK‐3β, a downstream effector of the D5R, was evaluated.ResultsAAV‐mediated knockdown of the D5R in the PFC induced learning and memory deficits. These changes were accompanied by elevations in PFC, OFC, and HIP theta spectral power and PFC‐OFC coherence, reduced PFC‐thalamus gamma coherence, and increased PFC GSK‐3β activity.ConclusionThis work demonstrates a role for PFC D5Rs in the regulation of neuronal oscillatory activity and learning and memory. As elevated GSK‐3β activity has been implicated in numerous disorders of cognitive dysfunction, this work also highlights the potential of the D5R as a novel therapeutic target via suppression of GSK‐3β.