bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of TrkB complex assemblies and localizing antidepressant targets using Artificial Intelligence
Authors: Xiang Xufu , Qian Chungen , Yao Hanbo , Li Pengjie , Cheng Bangning , Wei Daoshun , An Wenjun , Lu Yuming , Chu Ming , Wei Lanlan , Liu Bi-Feng , Xu Junfa , Liu Xin , Xia Fuzhen 
Published: February 2023

AbstractSince Major Depressive Disorder (MDD) represents a neurological pathology caused by inter-synaptic messaging errors, membrane receptors, the source of signal cascades, constitute appealing drugs targets. G protein-coupled receptors (GPCRs) and ion channel receptors chelated antidepressants (ADs) high-resolution architectures were reported to realize receptors physical mechanism and design prototype compounds with minimal side effects. Tyrosine kinase receptor 2 (TrkB), a receptor that directly modulates synaptic plasticity, has a finite three-dimensional chart due to its high molecular mass and intrinsically disordered regions (IDRs). Leveraging breakthroughs in deep learning, the meticulous architecture of TrkB was projected employing Alphfold 2 (AF2). Furthermore, the Alphafold Multimer algorithm (AF-M) models the coupling of intra- and extra-membrane topologies to chaperones: mBDNF, SHP2, Etc. Conjugating firmly dimeric transmembrane helix with novel compounds like 2R,6R-hydroxynorketamine (2R,6R-HNK) expands scopes of drug screening to encompass all coding sequences throughout genomes. The operational implementation of TrkB kinase-SHP2, PLCγ1, and SHC1 ensembles has paved the path for machine learning in which it can forecast structural transitions in the self-assembly and self-dissociation of molecules during trillions of cellular mechanisms. In silicon, the cornerstone of the alteration will be artificial intelligence (AI), empowering signal networks to operate at the atomic level and picosecond timescales.
Board Sustainability Committees, Climate Change Initiatives, Carbon Performance, and Market Value
Authors: Orazalin Nurlan S. , Ntim Collins G. , Malagila John K. 
Published: February 2023

AbstractWe examine the interrelationships among board sustainability committees, process‐based climate change initiatives, outcome‐based carbon performance, and market value through the lens of economic‐ and social‐based theoretical perspectives. Using a panel dataset of 8408 observations from 35 countries between 2002 and 2019, we find that higher levels of actual greenhouse gas (GHG) emissions are negatively associated with market value. Further, we reveal a positive association between process‐based climate change initiatives and market value. We then provide evidence that process‐based climate change initiatives are positively related to increased levels of GHG emissions. We also observe that the presence of a board sustainability committee has a positive impact on market value, but does not seem to improve outcome‐based carbon performance. Finally, we show that the predicted relationships vary across different country‐groups, sector‐groups, and periods. Our empirical findings are robust to alternative measures, endogeneities, and sample selection bias. Overall, our evidence supports the symbolic legitimation/greenwashing view, in that firms are likely to employ process‐based climate change initiatives under a symbolic approach to create positive impressions among stakeholders and protect their legitimacy.
Is This Verb a Word? A philological Study of the Distribution of Phonological and Morphological Domains in the Middle Welsh Verb
Authors: Dedio Stefan 
Published: February 2023

AbstractThe—for European languages—large amount of bound elements in the older Insular Celtic languages and the array of phonological interactions within morphological and phrasal structures have lead several researchers to conclude that individual words play a lesser role in the grammars of those languages. Based on current typological research on wordhood and a thorough discussion of the problems and limitations of studying wordhood in corpus languages, this article gives an in‐depth investigation of the morphological and phonological word‐like domains in the Middle Welsh verbal complex. There are several structures that could be labelled ‘word’ on the basis of the findings presented here, which leads to the conclusion that the term is not very useful for the synchronic description of this language.Die für indogermanische Sprachen große Menge gebundener Elemente in den älteren inselkeltischen Sprachen und die Prävalenz morphologischer und phonologischer Interaktion in morphologischen und syntaktischen Strukturen haben einige Forscher zu der Schlussfolgerung gebracht, dass die einzelnen Wörter in den Grammatiken dieser Sprachen eine untergeordnete Rolle spielen. Auf der Grundlage aktueller typologischer Forschung zu wordhood und einer Diskussion der Schwierigkeiten bei der Untersuchung von wordhood in Korpussprachen bietet dieser Artikel eine detaillierte Untersuchung der wortartigen Domänen im mittelkymrischen Verbalkomplex. Da es mehrere Strukturen gibt, die auf der Basis dieser Untersuchung als ‘Wort’ bezeichnet werden können, erscheint dieser Begriff für die synchrone Beschreibung dieser Sprache wenig hilfreich.[German]
After inclusion. Thinking with Julian Go's ‘Thinking against empire: Anticolonial thought as social theory’
Authors: Rutazibwa Olivia U. 
Published: February 2023

AbstractThis contribution engages Go's generative invitation tothink against empireby thinking through the epistemic and disciplinary implications of such endeavour. I zoom in on the need to explicitly address the purpose and ethos of scholarly inquiry and how that translates into decolonial academic praxis. Thinking with Go's invitation tothink against empire, I feel compelled to constructively engage the limitations and impossibilities of decolonising disciplines such as Sociology. I glean from the various attempts at inclusion and diversity in society and argue that adding or including Anticolonial Social Thought/marginalised voices and peoples in the existing corridors of power—such as canons or advisory boards—is at besta minimal rather than a sufficient conditionof decolonisation or goingagainst empire. This raises the question of what comesafter inclusion. Rather than offer a ‘correct’ or single alternative anticolonial way, the paper explores the pluriversally inspired method(ological) avenues that appear when we commit to thinking about what happensafter inclusionwhen the goal is decolonisation. I expand on my ‘discovery’ and engagement with the figure and political thought of Thomas Sankara and how this led me to abolitionist thought. The paper then offers a patchwork of methodological considerations when engaging thewhat, how, why?—questions of research. I engage with questions of purpose, mastery, and colonial science and turn to the generative potential of approaches such as grounding, Connected Sociologies, epistemic Blackness, and curating as methods. Thinking with abolition and Shilliam's (2015) distinction between colonial and decolonial science, between knowledgeproductionand knowledgecultivation, the paper invites us to not only think of what we need to do more of or better when taking Anticolonial Social Thought seriously, but also what we might need to let go of.
McDonald versus Shirodkar cerclage technique in the prevention of preterm birth: A systematic review and meta‐analysis
Authors: McAuliffe Liam , Issah Ashad , Diacci Rosanna , Williams Kimberley P. , Aubin Anne‐Marie , Phung Jason , Wang Carol , Maouris Alexander , Leathersich Sebastian , Maouris Panos , Pennell Craig E. 
Published: February 2023

AbstractBackgroundCervical cerclage has been used for decades to reduce preterm birth. The Shirodkar and McDonald cerclage are the most commonly used techniques with no current consensus on the preferred technique.ObjectiveTo compare the efficacy of the Shirodkar and McDonald cerclage techniques in preventing preterm birth.Search StrategyStudies were sourced from six electronic databases and reference lists.Selection CriteriaStudies including women with a singleton pregnancy, requiring a cervical cerclage, using either the Shirodkar or McDonald technique that ran comparative analyses between the two techniques.Data Collection and AnalysisThe primary outcome was preterm birth before 37 weeks, with analyses at 28, 32, 34 and 35 weeks. Secondary data were also collected on neonatal, maternal and obstetric outcomes.Main ResultsSeventeen papers were included: 16 were retrospective cohort studies and one was a randomised controlled trial. The Shirodkar technique was significantly less likely to result in preterm birth before 37 weeks than the McDonald technique (relative risk [RR] 0.91, 95% CI 0.85–0.98). This finding was supported by a statistically significant reduction in rates of preterm birth before 35, 34 and 32 weeks, PPROM, difference in cervical length, cerclage to delivery interval, and an increase in birthweight in the Shirodkar group. No difference was seen in preterm birth rates <28 weeks, neonatal mortality, chorioamnionitis, cervical laceration or caesarean section rates. The RR for preterm birth prior to 37 weeks was no longer significant when sensitivity analyses were performed removing studies with a serious risk of bias. However, similar analyses removing studies that utilised adjunctive progesterone strengthened the primary outcome (RR 0.83, 95% CI 0.74–0.93).ConclusionShirodkar cerclage reduces the rate of preterm birth prior to 35, 34 and 32 weeks’ gestation when compared with McDonald cerclage; however, the overall quality of the studies in this review is low. Further, large, well‐designed randomised controlled trials are required to address this important question to optimise care for women who may benefit from cervical cerclage.
Gut bacterium promotes host fitness in special ecological niche by affecting sugar metabolism in Drosophila suzukii
Authors: Gao Huan‐Huan , Zhao Shan , Wang Rui‐Juan , Qin Dong‐Yun , Chen Peng , Zhang An‐Sheng , Zhuang Qian‐Ying , Zhai Yi‐Fan , Zhou Xian‐Hong 
Published: February 2023

AbstractAs an important fruit pest of global significance, Drosophila suzukii occupies a special ecological niche, with the characteristics of high sugar and low protein contents. This niche differs from those occupied by other fruit‐damaging Drosophila species. Gut bacteria substantially impact the physiology and ecology of insects. However, the contribution of gut microbes to the fitness of D. suzukii in their special ecological niche remains unclear. In this study, the effect of Klebsiella oxytoca on the development of D. suzukii was examined at physiological and molecular levels. The results showed that, after the removal of gut microbiota, the survival rate and longevity of axenic D. suzukii decreased significantly. Reintroduction of K. oxytoca to the midgut of D. suzukii advanced the development level of D. suzukii. The differentially expressed genes and metabolites between axenic and K. oxytoca‐reintroduced D. suzukii were enriched in the pathways of carbohydrate metabolism. This advancement was achieved through an increased glycolysis rate and the regulation of the transcript level of key genes in the glycolysis/gluconeogenesis pathway. Klebsiella oxytoca is likely to play an important role in increasing host fitness in their high‐sugar ecological niche by stimulating the glycolysis/gluconeogenesis pathway. As a protein source, bacteria can also provide direct nutrition for D. suzukii, which depends on the quantity or biomass of K. oxytoca. This result may provide a new target for controlling D. suzukii by inhibiting sugar metabolism through eliminating the effect of K. oxytoca and thus disrupting the balance of gut microbial communities.
Transient asymptomatic pulmonary opacities in a patient with MET exon 14 skipping non‐small cell lung cancer: A case report
Authors: Ikeo Satoshi , Yasuda Naoaki , Sakai Yuki , Hayashi Yasuyuki , Sokai Akihiko , Iwata Toshiyuki , Nishimura Takashi 
Published: February 2023

AbstractMesenchymal epithelial transition factor receptor (MET) tyrosine kinase inhibitors (MET‐TKIs) have been approved for the treatment of non‐small cell lung cancers with MET exon 14 skipping mutations. Transient asymptomatic pulmonary opacities (TAPOs) associated with epidermal growth factor receptor (EGFR)‐TKIs have been reported. Here, we report a case wherein ground‐glass opacities (GGOs) appeared during the course of treatment with tepotinib, a MET‐TKI, but spontaneously resolved with drug withdrawal, after which treatment was resumed with a reduced dose. Although there have been no reports of TAPOs with MET‐TKIs, the clinical and imaging findings of this case were consistent with TAPOs. For TAPOs occurring because of MET‐TKI, the drug can be continued under careful observation even if GGOs appear.
A meta‐analysis of mRNA expression profiling studies in sheep with different FecB genotypes
Authors: Ma Xiaofei , Liu Aiju , Tian Shujun 
Published: February 2023

AbstractThe FecB mutation in the sheep BMPRIB is strongly correlated with high ovulation traits but its mechanism remains unclear. This study explored differentially expressed genes (DEGs) and their associated molecular mechanisms that may be involved in FecB mutation‐induced high ovulation from the perspective of the hypothalamic–pituitary–gonadal (HPG) axis by conducting a systematic review and meta‐analysis. The PubMed, EMBASE, CNKI, WanFang, and CBM databases were searched for eligible articles published before August 2022, focusing on mRNA sequencing of different tissues in the HPG axis in sheep with different FecB genotypes. A total of 6555 DEGs were identified from the analysis of six published articles and experimental results from our laboratory. The DEGs were screened by vote‐counting rank and robust rank aggregation. Among these, in the follicular phase, FKBP5, CDCA7 and CRABP1 were upregulated in the hypothalamus. INSM2 was upregulated, while LDB3 was downregulated in the pituitary. CLU, SERPINA14, PENK, INHA and STAR were upregulated, while FERMT2 and NPY1R were downregulated in the ovary. On the HPG axis, TAC1 was upregulated and NPNT was downregulated. Many DEGs were found in sheep with different FecB genotypes. The genes FKBP5, CDCA7, CRABP1, INSM2, LDB3, CLU, SERPINA14, PENK, INHA, STAR, FERMT2, NPY1R, TAC1 and NPNT, may be associated with FecB mutation‐induced high ovulation in different tissues. These candidate genes will further improve the mechanism of multiple fertility traits induced by the FecB mutation from the perspective of the HPG axis.
Population pharmacokinetics of intramuscular recombinant Erwinia chrysanthemi asparaginase (JZP458) in patients with acute lymphoblastic leukemia
Authors: Lin Tong , Whigham Tajhia , Fernando Indrasiri , Choi Mi Rim , Wang Qi , Silverman Jeffrey A. 
Published: February 2023

AbstractJZP458 is a recombinant Erwinia chrysanthemi asparaginase for patients with acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) who have developed hypersensitivity to Escherichia coli–derived asparaginases. A population pharmacokinetic (PopPK) model was developed for intramuscular (i.m.) JZP458 using serum asparaginase activity (SAA) data from 166 patients with ALL/LBL enrolled in a phase II/III study conducted in collaboration with the Children's Oncology Group (AALL1931; NCT04145531). The pharmacokinetics of i.m. JZP458 is best characterized by a one‐compartment model with mixed‐order absorption and linear elimination, with body surface area included as an allometric covariate on JZP458 SAA clearance and volume, and race (i.e., Black/African American) and disease subtype (i.e., T‐cell ALL) as covariates on JZP458 SAA clearance. The PopPK model was used to simulate SAA profiles to estimate the likelihood of achieving nadir SAA (NSAA) levels greater than or equal to 0.1 IU/mL with different dosing regimens. Model‐based simulations suggest when JZP458 is administered i.m. at 25/25/50 mg/m2 Monday/Wednesday/Friday (MWF), 92.1% of subjects (95% confidence interval [CI]: 90.9%, 93.3%) are expected to achieve the last 72‐h (after 50 mg/m2 dose) NSAA level greater than or equal to 0.1 IU/mL, and 93.8% (95% CI: 92.7%, 94.9%) are expected to achieve the last 48‐h (after 25 mg/m2 dose) NSAA level greater than or equal to 0.1 IU/mL. When JZP458 is administered 25 mg/m2 i.m. every 48 h, 93.8% (95% CI: 92.7%, 94.8%) are expected to achieve the last 48‐h NSAA level greater than or equal to 0.1 IU/mL. These data supported the i.m. dose of 25 mg/m2 every 48 h or 25/25/50 mg/m2 on a MWF dosing schedule in patients with ALL/LBL.
Regional inequalities and the West–East divide in Turkey since 1913
Authors: Aşık Güneş , Karakoç Ulaş , Pamuk Şevket 
Published: February 2023

AbstractThis paper examines the evolution of regional disparities within the present‐day borders of Turkey since 1913. Based on our estimates for 58 provinces, we findβ‐convergence, an inverse U, and more recently, the beginnings of an N‐shaped pattern for value added per capita. We also find that regional disparities in Turkey exhibit a number of special features that do not easily fit the well‐studied pattern of the early industrializers. First, while per capita value added in other regions moved towards country averages, the differences between the East and the rest of the country persisted and even increased until recently. Second, spatial distribution of economic activity became more concentrated over time due to continued migration to the megacity of Istanbul. Third, we find that regional disparities in per capita value added in Turkey and other developing countries have been higher than those experienced by the early industrializers. These findings raise questions about the extent to which the regional disparities experiences of Turkey and other developing countries have been different than those of the early industrializers.
Myrmecophily of the enigmatic stag beetleTorynognathus chrysomelinus(Coleoptera: Lucanidae: Lucaninae) with remarks on adult morphology, immature stages, and systematic position
Authors: Kakizoe Showtaro , Kakinuma Shunsuke , Hoshino Konosuke , Hashim Rosli , Abdullah Nurul Ashikin , Maruyama Munetoshi 
Published: February 2023

AbstractAdults and various immature stages of the stag beetleTorynognathus chrysomelinusBomans, 1986 were found inside the nests ofPseudolasiusants in Peninsular Malaysia. This paper provides a detailed description ofT. chrysomelinus, which is the first ever record of myrmecophily in this genus and the third record in the family Lucanidae. This is also the first record of myrmecophilous Coleoptera withPseudolasiusants as a host. The description includes the illustration of the male genitalia, mouthparts, larva, and pupa of this genus for the first time. Furthermore, the systematic position ofT. chrysomelinuswas inferred by the molecular phylogenetic analysis of the family Lucanidae. The results suggest thatTorynognathusis a sister taxon to the genusAegus.
IRF2BPL: A new genotype for progressive myoclonus epilepsies
Authors: Costa Cinzia , Oliver Karen L. , Calvello Carmen , Cameron Jillian M. , Imperatore Valentina , Tonelli Laura , Colavito Davide , Franceschetti Silvana , Canafoglia Laura , Berkovic Samuel F. , Prontera Paolo 
Published: February 2023

AbstractThe progressive myoclonus epilepsies (PMEs) are a heterogeneous group of neurodegenerative disorders, typically presenting in late childhood. An etiologic diagnosis is achieved in about 80% of patients with PME, and genome‐wide molecular studies on remaining, well‐selected, undiagnosed cases can further dissect the underlying genetic heterogeneity. Through whole‐exome sequencing (WES), we identified pathogenic truncating variants in the IRF2BPL gene in two, unrelated patients presenting with PME. IRF2BPL belongs to the transcriptional regulators family and it is expressed in multiple human tissues, including the brain. Recently missense and nonsense mutations in IRF2BPL were found in patients presenting with developmental delay and epileptic encephalopathy, ataxia, and movement disorders, but none with clear PME. We identified 13 other patients in the literature with myoclonic seizures and IRF2BPL variants. There was no clear genotype–phenotype correlation. With the description of these cases, the IRF2BPL gene should be considered in the list of genes to be tested in the presence of PME, in addition to patients with neurodevelopmental or movement disorders.
Accumulation of polyunsaturated fatty acid‐derived metabolites in the sarcopenic muscle of aging mice
Authors: Kadoguchi Tomoyasu , Shimada Kazunori , Fukui Naoshi , Tanaka Nobuho , Tsuno Hirotaka , Shiozawa Tomoyuki , Fukao Kosuke , Nishitani‐Yokoyama Miho , Isoda Kikuo , Matsushita Satoshi , Yokoyama Norihiko , Daida Hiroyuki 
Published: February 2023

AimAlthough it is known that advanced age alters skeletal muscle lipid metabolism, the role(s) of polyunsaturated fatty acid‐derived metabolites (mostly eicosanoids and docosanoids) in sarcopenia are not clear. We therefore examined the changes in the metabolites of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid in the sarcopenic muscle of aged mice.MethodsWe used 6‐ and 24‐month‐old male C57BL/6J mice as healthy and sarcopenic muscle models, respectively. Skeletal muscles were removed from the lower limb and subjected to a liquid chromatography–tandem mass spectrometry analysis.ResultsThe liquid chromatography–tandem mass spectrometry analysis detected distinct changes of metabolites in the muscles of the aged mice. Of the 63 metabolites identified, nine were significantly higher in the sarcopenic muscle of aged mice compared with the healthy muscle of young mice. In particular, prostaglandin E2, prostaglandin F2a, thromboxane B2, 5‐hydroxyeicosatetraenoic acid, and 15‐oxo‐eicosatetraenoic acid (arachidonic acid‐derived metabolites), 12‐hydroxy‐eicosapentaenoic acid and 14,15‐epoxy‐eicosatetraenoic acid (eicosapentaenoic acid‐derived metabolites) and 10‐hydroxydocosa‐hexaenoic acid and 14‐hydroxyoctadeca‐pentaenoic acid (docosahexaenoic acid‐derived metabolites) were significantly higher in aged tissue compared with young tissue (all P < 0.05).ConclusionsWe observed the accumulation of metabolites in the sarcopenic muscle of aged mice. Our results may provide new insights into the pathogenesis and progression of aging‐ or disease‐related sarcopenia. Geriatr Gerontol Int 2023; 23: 297–303.
Ror1 promotes PPARα‐mediated fatty acid metabolism in astrocytes
Authors: Tanaka Yuki , Minami Yasuhiro , Endo Mitsuharu 
Published: February 2023

AbstractRor1 signaling regulates cell polarity, migration, proliferation, and differentiation during developmental morphogenesis, and plays an important role in regulating neurogenesis in the embryonic neocortices. However, the role of Ror1 signaling in the brains after birth remains largely unknown. Here, we found that expression levels of Ror1 in the mouse neocortices increase during the postnatal period, when astrocytes mature and start expressing GFAP. Indeed, Ror1 is highly expressed in cultured postmitotic mature astrocytes. RNA‐Seq analysis revealed that Ror1 expressed in cultured astrocytes mediates upregulated expression of genes related to fatty acid (FA) metabolism, including the gene encoding carnitine palmitoyl‐transferase 1a (Cpt1a), the rate‐limiting enzyme of mitochondrial fatty acid β‐oxidation (FAO). We also found that Ror1 promotes the degradation of lipid droplets (LDs) accumulated in the cytoplasm of cultured astrocytes after oleic acid loading, and that suppressed expression of Ror1 decreases the amount of FAs localized at mitochondria, intracellular ATP levels, and expression levels of peroxisome proliferator‐activated receptor α (PPARα) target genes, including Cpt1a. Collectively, these findings indicate that Ror1 signaling promotes PPARα‐mediated transcription of FA metabolism‐related genes, thereby facilitating the availability of FAs derived from LDs for mitochondrial FAO in the mature astrocytes.