bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUSE Analysis of Gas around Galaxies (MAGG) – V. Linking ionized gas traced by C iv and Si iv absorbers to Ly α emitting galaxies at z ≈ 3.0–4.5
Authors: Galbiati Marta , Fumagalli Michele , Fossati Matteo , Lofthouse Emma K , Dutta Rajeshwari , Prochaska J Xavier , Murphy Michael T , Cantalupo Sebastiano 
Published: July 2023

ABSTRACT
We study the connection between Ly α emitters (LAEs) and metal-enriched ionized gas traced by C iv absorption at redshift z ≈ 3–4 in 28 quasar fields with high-resolution spectroscopy from the MUSE Analysis of Gas Around Galaxies survey. In a sample of 220 C iv absorbers, we identify 143 LAEs connected to C iv gas within a line-of-sight separation $\pm 500\rm \, km\, s^{-1}$, equal to a detection rate of 36 ± 5 per cent once we account for multiple LAEs connected to the same absorber. The luminosity function of LAEs associated with absorbers has an ≈2.4 higher normalization than the field. The analysis of the LAE–C iv correlation function suggests that metal-enriched gas arises both in the haloes of the LAEs and from locations not connected to galaxies. C iv absorbers with higher equivalent width are more often associated with LAEs and C iv systems are twice less likely, especially at low equivalent width, to be found near LAEs than strong H i absorbers. The covering fraction in groups is up to ≈3 times larger than for isolated galaxies. Similar results are found using Si iv as tracer of ionized gas. We propose three components to model the gas environment of LAEs: (i) the circumgalactic medium of galaxies, accounting for the strongest correlations between absorption and emission; (ii) overdense gas filaments connecting galaxies, driving the excess of LAEs at a few times the virial radius and the modulation of the luminosity and cross-correlation functions for strong absorbers; (iii) an enriched and more diffuse medium, accounting for weaker C iv absorbers farther from galaxies.
An alternative formation scenario for uranium-rich giants: engulfing an Earth-like planet
Authors: Xie Dian , Zhu Chunhua , Guo Sufen , Liu Helei , Lü Guoliang 
Published: July 2023

ABSTRACT
The actinides, such as the uranium (U) element, are typically synthesized through the rapid neutron-capture process (r-process), which can occur in core-collapse supernovae or double neutron star mergers. There exist nine r-process giant stars exhibiting conspicuous U abundances, commonly referred to as U-rich giants. However, the origins of these U-rich giants remain ambiguous. We propose an alternative formation scenario for these U-rich giants whereby a red giant (RG) engulfs an Earth-like planet. To approximate the process of an RG engulfing an Earth-like planet, we employ an accretion model wherein the RG assimilates materials from said planet. Our findings demonstrate that this engulfment event can considerably enhance the presence of heavy elements originating from Earth-like planets on the surfaces of very metal-poor stars (Z = 0.00001), while its impact on solar-metallicity stars is comparatively modest. Importantly, the structural and evolutionary properties of both very metal-poor and solar-metallicity stars remain largely unaffected. Notably, our engulfment model effectively accounts for the observed U abundances in known U-rich giants. Furthermore, the evolutionary trajectories of U abundances on the surfaces of RGs subsequent to the engulfment of Earth-like planets encompass all known U-rich giants. Therefore, it is plausible that U-rich giants are formed when an RG engulfs an Earth-like planet.
Transition to Self-compatibility Associated With Dominant S-allele in a Diploid Siberian Progenitor of Allotetraploid Arabidopsis kamchatica Revealed by Arabidopsis lyrata Genomes
Authors: Kolesnikova Uliana K , Scott Alison Dawn , Van de Velde Jozefien D , Burns Robin , Tikhomirov Nikita P , Pfordt Ursula , Clarke Andrew C , Yant Levi , Seregin Alexey P , Vekemans Xavier , Laurent Stefan , Novikova Polina Yu 
Published: July 2023

Abstract
A transition to selfing can be beneficial when mating partners are scarce, for example, due to ploidy changes or at species range edges. Here, we explain how self-compatibility evolved in diploid Siberian Arabidopsis lyrata, and how it contributed to the establishment of allotetraploid Arabidopsis kamchatica. First, we provide chromosome-level genome assemblies for two self-fertilizing diploid A. lyrata accessions, one from North America and one from Siberia, including a fully assembled S-locus for the latter. We then propose a sequence of events leading to the loss of self-incompatibility in Siberian A. lyrata, date this independent transition to ∼90 Kya, and infer evolutionary relationships between Siberian and North American A. lyrata, showing an independent transition to selfing in Siberia. Finally, we provide evidence that this selfing Siberian A. lyrata lineage contributed to the formation of the allotetraploid A. kamchatica and propose that the selfing of the latter is mediated by the loss-of-function mutation in a dominant S-allele inherited from A. lyrata.
Intravenous Liposomal Amphotericin B Efficacy and Safety for Cutaneous and Mucosal Leishmaniasis: A Systematic Review and Meta-analysis
Authors: Chivinski Jeffrey , Nathan Keren , Naeem Faheel , Ekmekjian Taline , Libman Michael D , Barkati Sapha 
Published: July 2023

Abstract

Background
Tegumentary leishmaniasis is often subject to limited funding, underpowered studies, and a paucity of high-quality interventional studies. Intravenous liposomal amphotericin B (L-AmB) has been increasingly used to treat cutaneous and mucosal leishmaniasis (CL and ML, respectively) despite the lack of well-conducted interventional studies. We conducted a systematic review to consolidate the descriptive evidence on the efficacy and safety of L-AmB in treating CL and ML.

Methods
Several online databases and the reference lists of included studies were searched to extract data from 132 studies comprising both case reports and case series. The population, intervention, comparison, outcome, and study design strategy and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used.

Results
Of 132 studies included, 92 were case reports and 40 were case series. Of the 92 cases, 65 (82.3%) were considered cured after receiving L-AmB as part of their treatment regimen. Twenty-one of the 92 (22.8%) cases reported adverse reactions to L-AmB. A pooled cure rate of 87.0% (95% CI, 79.0%–92.0%) was reported for the 38 case series that reported on treatment efficacy; 40.7% of the cases were associated with an adverse reaction.

Conclusions
Observational data on cure rates using L-AmB suggest efficacy between 80% and 90%, similar to rates reported for other antileishmanial drugs. The highest efficacy rates were observed when a single cycle of L-AmB was administered to patients with mild–moderate CL and ML. The limitations of this study include the heterogeneity observed among the included studies and the increased likelihood of publication bias associated with the inclusion of case reports and case series. This systematic review further illustrates the need for high-quality comparative trials of intravenous L-AmB for the treatment of tegumentary leishmaniasis.
A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess
Authors: Bläckberg Anna , Jönsson Astrid , Svensson Emma , Sunnerhagen Torgny , Kiasat Ali , Ljungquist Oskar 
Published: July 2023

Abstract

Background
Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.

Methods
We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.

Results
A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA rate was 20% (n = 92). In a multivariable logistic regression model, female sex (odds ratio [OR], 2.0 [95% confidence interval {CI}, 1.1–3.9]), malignancy (OR, 3.7 [95% CI, 1.9–7.1]), liver failure (OR, 6.3 [95% CI, 2.7–14.5]), and polymicrobial findings (OR, 3.8 [95% CI, 2.2–6.9]) were associated with death within 90 days (P &lt; .05). Male sex (OR, 2.1 [95% CI, 1.2–3.6]), malignancy (OR, 2.1 [95% CI, 1.3–3.6]), age (64–74 years: OR, 2.5 [95% CI, 1.3–4.8]), and chronic liver disease (OR, 3.0 [95% CI, 1.4–6.5]) were associated with the risk of subsequent PLA (P ≤ .01).

Conclusions
Identifying different clinical variables associated with an unfavorable outcome may improve the management and treatment of patients with PLA and thus prevent the risk of death and subsequent PLA.
Tuberculosis Infection and Disease Among Pregnant People Living in Sweden With Origin in Tuberculosis-Endemic Countries
Authors: Båtshake Ylva , Walles John , Winqvist Niclas , Björkman Per 
Published: July 2023

Abstract

Background
Pregnancy has been associated with elevated incidence of tuberculosis (TB) disease. Since 2014, people living in Sweden with origin in TB-endemic countries have been offered screening for TB infection in antenatal care (ANC) using Quantiferon-TB assays. We assessed factors associated with TB infection in this population and determined the incidence of TB disease during pregnancy and postpartum periods with regard to ANC Quantiferon-TB results.

Methods
Quantiferon-TB results obtained during ANC in Sweden, 2014–2018, were linked to data from national registers (Pregnancy Register, Patient Register and Tuberculosis Register). Factors associated with TB infection (defined as Quantiferon-TB ≥0.35 IU/mL) were identified using logistic regression analysis. Incidence of TB disease was determined with regard to pregnancy, postpartum and subsequent periods, and ANC Quantiferon-TB results.

Results
Among 7638 screened individuals, 1424 (18.6%) had TB infection. Tuberculosis infection was independently associated with higher age at immigration (adjusted odds ratio, 1.04 [95% confidence interval, 1.03–1.05]; P &lt; .001), and was more common among people originating from Africa compared to other world regions (845/3088 [27.4%] vs 579/4550 [12.7%]; P &lt; .001). In total, 16 participants were diagnosed with TB disease (10 during pregnancy, 4 at &lt;6 months after delivery, 2 at &gt;6 months after delivery); among these, all diagnosed during pregnancy/postpartum had positive ANC Quantiferon-TB results (constituting 14/1424 [1%] of people with TB infection).

Conclusions
Among pregnant people screened in Swedish ANC, TB infection was associated with higher age and African origin. All cases of TB disease reported in persons with TB infection at ANC screening occurred during pregnancy or postpartum.
Cardiometabolic Parameters 3 Years After Switch to Dolutegravir/Lamivudine vs Maintenance of Tenofovir Alafenamide–Based Regimens
Authors: Batterham Rachel L , Espinosa Nuria , Katlama Christine , McKellar Mehri , Scholten Stefan , Smith Don E , Ait-Khaled Mounir , George Nisha , Wright Jonathan , Gordon Lori A , Moodley Riya , Wynne Brian , van Wyk Jean 
Published: July 2023

Abstract

Background
Cardiometabolic outcomes were investigated 3 years after switching to the 2-drug regimen dolutegravir/lamivudine (DTG/3TC) vs continuing 3-/4-drug tenofovir alafenamide (TAF)–based regimens in a multicenter phase 3 noninferiority study based on an open-label randomized design.

Method
Adults with virologically suppressed HIV-1 switched to once-daily DTG/3TC (n = 369) or continued TAF-based regimens (n = 372). Cardiometabolic health parameters were assessed through week 144 via mixed-model repeated measures or logistic regression analyses, adjusting for baseline variables.

Results
At week 144, 13% (42/316) of the DTG/3TC group and 12% (37/303) of the TAF-based regimen group had ≥10% weight gain from baseline (adjusted odds ratio, 1.11; 95% CI, .68–1.80). Adjusted change from baseline in serum leptin, a surrogate marker of adiposity, was similar between groups (treatment ratio, 1.00; 95% CI, .89–1.13). The lipid profile generally favored DTG/3TC in the baseline boosted subgroup. Adjusted odds revealed no clinically meaningful differences between groups: homeostatic model assessment of insulin resistance ≥2 (adjusted odds ratio, 0.79; 95% CI, .50–1.26), metabolic syndrome (International Diabetes Federation criteria, 0.99; .59–1.68), hepatic fibrosis (fibrosis-4 index score ≥1.45, 1.39; .63–3.06), and coronary artery disease risk (Framingham risk score ≥10%, 0.92; .56–1.49). Baseline variables and characteristics associated with odds of each cardiometabolic parameter outcome were consistent with known risk factors, including age, sex, race, and some disease characteristics.

Conclusions
Cardiometabolic health 3 years after switching to DTG/3TC was comparable to that for individuals continuing TAF-based regimens, further supporting DTG/3TC as a robust switch option with a stable metabolic profile.

Trial registration
ClinicalTrials.gov NCT03446573
Multidrug-Resistant Bacterial Infections Among Very Low Birthweight Infants With Late-Onset Sepsis in Johannesburg, South Africa
Authors: Licona Genesis , Ballot Daynia , Moon Troy D , Banerjee Ritu , Amorim Gustavo , Agthe Alexander G , Weitkamp Jörn-Hendrik 
Published: July 2023

Abstract

Background
An estimated 2.4 million babies died within the first 28 days of life in 2020. The third leading cause of neonatal death continues to be neonatal sepsis. Sepsis-causing bacterial pathogens vary temporally and geographically and, with a rise in multidrug-resistant organisms (MDROs), pose a threat to the neonatal population.

Methods
This was a single-center, retrospective study of very low birth weight (VLBW) infants with late-onset sepsis (LOS) admitted to a neonatal unit in South Africa. We aimed to calculate the prevalence of multidrug-resistant (MDR) infections in this population. The data collected included demographic and clinical characteristics, length of hospital stay, risk factors for MDRO and mortality, and microbiology results. Logistic regression was used to assess the association between prespecified risk factors with MDR infections and mortality.

Results
Of 2570 VLBW infants admitted, 34% had LOS, of which 33% was caused by MDROs. Infection with Acinetobacter spp., Pseudomonas spp., extended-spectrum beta-lactamase Klebsiella spp., or Escherichia coli was associated with the highest mortality in the LOS cohort. Infants with congenital infections (adjusted odds ratio [aOR], 5.13; 95% CI, 1.19–22.02; P = .028) or a history of necrotizing enterocolitis (aOR, 2.17; 95% CI, 1.05–4.49; P = .037) were at significantly higher risk for MDR infections.

Conclusions
More than one-third of LOS cases in VLBW infants were caused by MDROs in this study. MDR infections cause substantial neonatal mortality. Antimicrobial stewardship programs, infection control protocols, and ongoing surveillance are needed to prevent further emergence and spread of MDR infections worldwide.
Evolution of cytosolic and organellar invertases empowered the colonization and thriving of land plants
Authors: Wan Hongjian , Zhang Youjun , Wu Limin , Zhou Guozhi , Pan Luzhao , Fernie Alisdair R , Ruan Yong-Ling 
Published: July 2023

Abstract
The molecular innovation underpinning efficient carbon and energy metabolism during evolution of land plants remains largely unknown. Invertase-mediated sucrose cleavage into hexoses is central to fuel growth. Why some cytoplasmic invertases (CINs) function in the cytosol, whereas others operate in chloroplasts and mitochondria, is puzzling. We attempted to shed light on this question from an evolutionary perspective. Our analyses indicated that plant CINs originated from a putatively orthologous ancestral gene in cyanobacteria and formed the plastidic CIN (α1 clade) through endosymbiotic gene transfer, while its duplication in algae with a loss of its signal peptide produced the β clade CINs in the cytosol. The mitochondrial CINs (α2) were derived from duplication of the plastidic CINs and coevolved with vascular plants. Importantly, the copy number of mitochondrial and plastidic CINs increased upon the emergence of seed plants, corresponding with the rise of respiratory, photosynthetic, and growth rates. The cytosolic CIN (β subfamily) kept expanding from algae to gymnosperm, indicating its role in supporting the increase in carbon use efficiency during evolution. Affinity purification mass spectrometry identified a cohort of proteins interacting with α1 and 2 CINs, which points to their roles in plastid and mitochondrial glycolysis, oxidative stress tolerance, and the maintenance of subcellular sugar homeostasis. Collectively, the findings indicate evolutionary roles of α1 and α2 CINs in chloroplasts and mitochondria for achieving high photosynthetic and respiratory rates, respectively, which, together with the expanding of cytosolic CINs, likely underpin the colonization of land plants through fueling rapid growth and biomass production.
Genicular nerve radiofrequency ablation for the treatment of chronic knee joint pain: a real-world cohort study with evaluation of prognostic factors
Authors: Caragea Marc , Woodworth Tyler , Curtis Tim , Blatt Michael , Cheney Cole , Brown Todd , Carson Daniel , Kuo Keith T , Randall Dustin , Huang Emily Y , Carefoot Andrea , Teramoto Masaru , Mills Megan , Cooper Amanda , Burnham Taylor , Conger Aaron , McCormick Zachary L 
Published: July 2023

Abstract

Background
Genicular nerve radiofrequency ablation (GNRFA) is an effective treatment for chronic knee pain. However, there has been minimal investigation of real-world, long-term outcomes and factors that predict treatment success after GNRFA.

Objectives
To evaluate the effectiveness of GNRFA for chronic knee pain in a real-world population and identify predictive factors.

Methods
Consecutive patients who underwent GNRFA at a tertiary academic center were identified. Demographic, clinical, and procedural characteristics were collected from the medical record. Outcome data were numeric rating scale (NRS) pain reduction and Patient Global Impression of Change (PGIC). Data were collected by standardized telephone survey. Predictors of success were evaluated with logistic and Poisson regression analyses.

Results
Of the 226 total patients identified, 134 (65.6 ± 12.7; 59.7% female) were successfully contacted and analyzed, with a mean follow-up time of 23.3 ± 11.0 months. Of those, 47.8% (n = 64; 95% CI: 39.5%–56.2%) and 61.2% (n = 82; 95% CI: 52.7%–69.0%) reported ≥50% NRS score reduction and ≥2-point NRS score reduction, respectively, and 59.0% (n = 79; 95% CI: 50.5%–66.9%) reported “much improved” on the PGIC questionnaire. Factors associated with a greater likelihood of treatment success (P &lt; .05) were higher Kellgren–Lawrence osteoarthritis grade (2–4 vs 0–1); no baseline opioid, antidepressant, or anxiolytic medication use; and &gt;3 nerves targeted.

Conclusion
In this real-world cohort, approximately half of the participants experienced clinically meaningful improvements in knee pain after GNRFA at an average follow-up time of nearly 2 years. Factors associated with higher likelihood of treatment success were more advanced osteoarthritis (Kellgren–Lawrence Grade 2–4); no opioid, antidepressant, or anxiolytic medication use; and &gt;3 nerves targeted.
Frailty predicts knee pain trajectory over 9 years: results from the Osteoarthritis Initiative
Authors: Cai Guoqi , Zhang Youyou , Wang Yining , Li Xiaoxi , Xu Shengqian , Shuai Zongwen , Pan Faming , Peng Xiaoqing 
Published: July 2023

Abstract

Objective
Frailty is a multisystem syndrome and its relationship with symptomatic osteoarthritis has been reported. We aimed to identify trajectories of knee pain in a large prospective cohort and to describe the effect of frailty status at baseline on the pain trajectories over 9 years.

Methods
We included 4419 participants (mean age 61.3 years, 58% female) from the Osteoarthritis Initiative cohort. Participants were classified as “no frailty,” “pre-frailty,” or “frailty” at baseline, based on 5 characteristics (ie, unintentional weight loss, exhaustion, weak energy, slow gait speed, and low physical activity). Knee pain was evaluated annually using the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale (0–20) from baseline to 9 years.

Results
Of the participants included, 38.4%, 55.4%, and 6.3% were classified as “no frailty,” “pre-frailty,” and “frailty,” respectively. Five pain trajectories were identified: “No pain” (n = 1010, 22.8%), “Mild pain” (n = 1656, 37.3%), “Moderate pain” (n = 1149, 26.0%), “Severe pain” (n = 477, 10.9%), and “Very Severe pain” (n = 127, 3.0%). Compared to participants with no frailty, those with pre-frailty and frailty were more likely to have more severe pain trajectories (pre-frailty: odds ratios [ORs] 1.5 to 2.1; frailty: ORs 1.5 to 5.0), after adjusting for potential confounders. Further analyses indicated that the associations between frailty and pain were mainly driven by exhaustion, slow gait speed, and weak energy.

Conclusions
Approximately two-thirds of middle-aged and older adults were frail or pre-frail. The role of frailty in predicting pain trajectories suggests that frailty may be an important treatment target for knee pain.
The (moral) language of hate
Authors: Kennedy Brendan , Golazizian Preni , Trager Jackson , Atari Mohammad , Hoover Joe , Mostafazadeh Davani Aida , Dehghani Morteza 
Published: July 2023

AbstractHumans use language toward hateful ends, inciting violence and genocide, intimidating and denigrating others based on their identity. Despite efforts to better address the language of hate in the public sphere, the psychological processes involved in hateful language remain unclear. In this work, we hypothesize that morality and hate are concomitant in language. In a series of studies, we find evidence in support of this hypothesis using language from a diverse array of contexts, including the use of hateful language in propaganda to inspire genocide (Study 1), hateful slurs as they occur in large text corpora across a multitude of languages (Study 2), and hate speech on social-media platforms (Study 3). In post hoc analyses focusing on particular moral concerns, we found that the type of moral content invoked through hate speech varied by context, with Purity language prominent in hateful propaganda and online hate speech and Loyalty language invoked in hateful slurs across languages. Our findings provide a new psychological lens for understanding hateful language and points to further research into the intersection of morality and hate, with practical implications for mitigating hateful rhetoric online.