bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent to parent violence as a form of family (domestic) violence: the issue of expanding the object of state-legal protection of the individual in the family
Authors: Ravnyushkin Aleksandr 
Published: July 2023

The article examines the issues of adolescent to parents violence as a separate form of family (domestic) violence, substantiates the problematic nature of this unlawful phenomenon on the basis of analysis and generalization of the results of scientific research of Russian and foreign scientists, including their sociological and other data obtained. The relevance of the work is expressed in the fact that adolescent family violence, as a negative phenomenon, leads to harmful consequences that threaten the development of other family members and society as a whole on the basis of high moral ideals and a strong family.
The aim of the work is to study and determine the degree of public and scientific recognition of the problem of adolescent to parent violence as such in legal and other aspects, to identify it as a separate form of family (domestic) violence, to establish its special features and to adjust the conceptual apparatus for its inclusion in legal and scientific circulation.
The author applied a dialectical approach to the scientific knowledge of social relations related to the acts of violence committed by children (adolescents) against parents, a method of analyzing and generalizing scientific research results, a comparative legal method.
The results of the study confirm a hypothesis that there is a phenomenon of adolescent violence against parents (mother), its recognition as a separate form of family violence based on the identified special features, the development of author’s formulations of concepts in the relevant field, as well as the proposal of an expanded understanding of the object of state-legal protection of individual rights from domestic (family) violence, depending on the type of perpetrator.
The scientific novelty of the study is determined by the fact that in the Russian Federation the phenomenon of the acts of violence committed by minors (adolescents) in the family has not been considered as a separate form of domestic (family) violence. Based on the obtained generalized results of the study, the author presented the adjusted formulations of the concepts of family violence and domestic abuse to include them in the legal and scientific circulation, which gave the work practical significance.
Public Transportation Slang
Authors: Hadwijaya Munawwir , Ifianti Trisnian , Yahmun Yahmun 
Published: July 2023

As a product of creativity, slang continuously raises in society used to mark social and cultural differences. This study aims to discover terms of slang used by the community of public transportation drivers in Kacuk Malang, the process of its formation, the meaning it refers to, and the purpose of its usage. Qualitative design is used as the research method by using the following steps in collecting and analyzing data. The observation was done to gain information about using slang in conversation among public transportation drivers and followed up by interviewing ten drivers. The study found that Slang was used for a variety of purposes. Initially, as their code language. As a language for jokes, second. Third, they use Bahasa Jawa (Javanese language) as words or supplementary language to keep the discourse fresh and further demonstrate their Kacuk community identity. Fifth, as a way to get to know one another better. The final one was for their regular discussions.

Keywords: kacuk slang, slang, osob ngalaman
The Use of Kahoot! Application to Teach English Vocabulary Learning in Rural Area
Authors: Surayya ST Ayu , Jaelani Selamet Riadi , Ilmiani Ilmiani 
Published: July 2023

The purpose of this study was to find out the effectiveness of Kahoot! application in teaching vocabulary at the eighth grade of MTs NWDI Lepak in the academic year 2021-2022. This study refers to mix method where a pre-experimental design using one group pre-test and post-test was used to find out the effectiveness of using Kahoot!, then observation was used to find out the students’ attitude on Kahoot! The sample of this study was the eighth-grade students consisting of 30 students. The data were collected from students’ pre-test and post-test by using multiple tests. The data were analyzed by using SPSS version 22 for Windows. After submitting the data to a paired sample t-test, it was found that there was a significant difference in the mean score between the pre-test and post-test, t(df=22)= -14.31 at p=0.00 which meant that the alternative hypothesis was accepted and the null hypothesis was rejected. Thus, Kahoot! The application was significantly effective in teaching students’ vocabulary in the eighth grade of MTs NWDI Lepak in the academic year 2021-2022. Considering the process and result of this study, it was suggested that English teachers use this media in teaching English vocabulary, both in urban and rural areas.

Keywords: kahoot! application, rural area, vocabulary
แบบจำลองการวัดโซ่อุปทานบริการของโรงพยาบาลในกรุงเทพมหานคร
Authors: Cheunkamon Ekkapong , Naksuetrong Somporn 
Published: July 2023

งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนาแบบจำลองการวัดองค์ประกอบเชิงยืนยันห่วงโซ่อุปทานบริการของโรงพยาบาลในกรุงเทพมหานคร กลุ่มตัวอย่างที่ใช้สำหรับการศึกษา คือ บุคคลากรทางการแพทย์ที่มีต่อการให้บริการของโรงพยาบาลในกรุงเทพมหานคร จำนวน 446 ที่มีประสบการณ์ในการทำงานไม่น้อยกว่า 1 ปีขึ้นไป โดยใช้แบบสอบถามชนิดมาตรวัดแบบลิเคอร์ท 5 ระดับ โดยใช้การวิเคราะห์องค์ประกอบเชิงสำรวจ และการวิเคราะห์องค์ประกอบเชิงยืนยัน ผลการศึกษาพบว่าการตรวจสอบข้อมูลเชิงประจักษ์มีความสอดคล้องกลมกลืน มีค่า χ2=266.483, df=155, p<0.001, χ2/df=1.719, RMSEA=0.040, CFI=0.970, TLI=0.964, SRMR=0.044 เป็นไปตามเกณฑ์พิจารณาความสอดคล้องในระดับดี แบบจำลองการวัดห่วงโซ่อุปทานบริการของโรงพยาบาลในกรุงเทพมหานครมีองค์ประกอบ 6 ปัจจัย ได้แก่ 1) การจัดการความสามารถและทรัพยากร 2) การจัดการกระบวนการสั่งซื้อ 3) การจัดการความต้องการ 4) การจัดการความสัมพันธ์ของลูกค้า 5) การจัดการความสัมพันธ์ซัพพลายเออร์ และ 6) การจัดการประสิทธิภาพการบริการ ผลการศึกษาในครั้งนี้สามารถนำไปใช้เป็นแนวทางในการปรับปรุงการบริการให้มีความแตกต่างและสามารถตอบโจทย์ลูกค้าเพื่อเพิ่มความสามารถในการแข่งขันในธุรกิจทางการแพทย์
Prevalence, Pattern and Outcome of Adult Renal Diseases among Admissions in Rivers State University Teaching Hospital: A 4 Year Review
Authors: Okachi Elageche W. , Eleki Beniboba J. , Briggs Datonye C. , Membere Ibinabo 
Published: July 2023

Introduction: Kidney disease is a growing worldwide public health problem and prevalence varies within and between countries. Epidemiological data is therefore imperative for prioritization and adequate resource allocation, especially in settings where no previous data exists.
Aim: To determine the prevalence and pattern of renal diseases among adults admitted into the medical wards of Rivers State University Teaching Hospital, Rivers State, Southern Nigeria.
Methods: Case notes of all patients admitted into the medical wards were reviewed from January 2019 to December 2022. Data extracted included sociodemographic variables, diagnosis and treatment outcomes of patients with renal disease.
Results: Of the 2,725 patients admitted to the medical wards, 386 (14.2%) had renal disease. The mean age of patients was 51.2 ± 16 years. There was a male preponderance of 210 (54.4%) with a M: F = 1.3:1. The most prevalent renal diseases were hypertensive nephropathy 125(32.4%), diabetic nephropathy 91(23.7%), HIV-related renal disease 54(14.0%) and obstructive uropathy 23(6%). Acute kidney injury constituted 37 (9.6%) of renal admissions. Analysis of outcome showed that 254 (65.8%) were discharged home, 17 (4.4%) patients discharged themselves against medical advice, 5 (1.3%) absconded, 2 (0.5%) referred and 108 (28.0%) of them died. The highest mortality (19.4%) occurred among patients with the HIV-related renal disease
Conclusion: The prevalence of renal disease is high, with hypertension, diabetes, HIV and obstructive uropathy as its commonest risk factors. Renal diseases still contribute significantly to morbidity and mortality among in-hospital admissions in Rivers State, Southern Nigeria. Preventative measures including health education, advocacy and screening for renal disease are imperative.
Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 pathway
Authors: Liang Jinrong , Zhang Peng , He Kunyan , Zhang Yawen , Ding Xiaomin , Li Qian , Zhou Wang , Hu Haiyan , Zhang Jianjun , Zhou Yan 
Published: July 2023

AbstractPurposeTopoisomerase 1 (TOP1) plays a crucial role in various cell cycle processes and its dysregulation can lead to the development of multiple tumours. However, conventional TOP1 inhibitors such as topotecan and irinotecan have poor clinical efficacy in osteosarcoma (OS) patients. This is partly due to the activation of the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 (ATR/CHEK1) DNA damage repair pathway, which repairs TOP1 poison‐induced DNA lesions, compromises the cytotoxicity of TOP1 inhibitors and contributes to drug resistance. Therefore, there is a need to develop more effective TOP1 inhibitors for OS.Experimental designIn this study, we evaluated the antitumor effects of isovalerylspiramycin I (ISP‐I), a novel macrolide antibiotic, using various assays including CCK‐8 proliferation assays, wound healing migration assays, Transwell invasion assays, apoptosis, cell cycle, DNA replication and damage analyses on OS cells. We also performed a surface plasmon resonance‐high‐performance liquid chromatography‐mass spectrometry assay to identify ISP‐I's direct target protein in OS. Molecular docking analysis, thermoshift assays, enzyme activity assays and reverse tests were used to confirm ISP‐1′s target. Finally, we tested the efficacy of ISP‐I in vivo using a tumour xenograft model.ResultsOur results showed that ISP‐I significantly suppressed the growth of OS cells both in vitro and in vivo. Furthermore, ISP‐I dose‐dependently inhibited cell migration and invasion, and induced apoptosis and cell cycle arrest in OS cells. Mechanistically, ISP‐I directly bound to TOP1 and inhibited DNA replication. Additionally, ISP‐I significantly downregulated the ATR/CHEK1 pathway, which led to the suppression of DNA damage repair, ultimately augmenting DNA damage and triggering cell death.ConclusionsIn conclusion, our study suggests that ISP‐I could be a novel TOP1 inhibitor that does not activate the ATR/CHEK1 DNA damage repair pathway. This characteristic allows ISP‐I to synergistically inhibit OS cell proliferation, migration and invasion. ISP‐I may represent a promising candidate for the treatment of OS.
Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease
Authors: He Sijia , Qiu Shulan , Pan Meixia , Palavicini Juan P. , Wang Hu , Li Xin , Bhattacharjee Anindita , Barannikov Savannah , Bieniek Kevin F. , Dupree Jeffrey L. , Han Xianlin 
Published: July 2023

AbstractBackgroundDespite being a brain disorder, Alzheimer's disease (AD) is often accompanied by peripheral organ dysregulations (e.g., loss of bladder control in late‐stage AD), which highly rely on spinal cord coordination. However, the causal factor(s) for peripheral organ dysregulation in AD remain elusive.MethodsThe central nervous system (CNS) is enriched in lipids. We applied quantitative shotgun lipidomics to determine lipid profiles of human AD spinal cord tissues. Additionally, a CNS sulfatide (ST)‐deficient mouse model was used to study the lipidome, transcriptome and peripheral organ phenotypes of ST loss.ResultsWe observed marked myelin lipid reduction in the spinal cord of AD subjects versus cognitively normal individuals. Among which, levels of ST, a myelin‐enriched lipid class, were strongly and negatively associated with the severity of AD. A CNS myelin‐specific ST‐deficient mouse model was used to further identify the causes and consequences of spinal cord lipidome changes. Interestingly, ST deficiency led to spinal cord lipidome and transcriptome profiles highly resembling those observed in AD, characterized by decline of multiple myelin‐enriched lipid classes and enhanced inflammatory responses, respectively. These changes significantly disrupted spinal cord function and led to substantial enlargement of urinary bladder in ST‐deficient mice.ConclusionsOur study identified CNS ST deficiency as a causal factor for AD‐like lipid dysregulation, inflammation response and ultimately the development of bladder disorders. Targeting to maintain ST levels may serve as a promising strategy for the prevention and treatment of AD‐related peripheral disorders.
Integrating the social determinants of mental health into case conceptualization and treatment planning
Authors: Lenz A. Stephen , Litam Stacey Diane A. 
Published: July 2023

AbstractThe social determinants of mental health (SDMH) have strong associations with the physiological and psychological stress that are frequently the impetus for client referrals. Despite the increasing momentum of SDMH within areas of education, assessment, and advocacy, examples of their integration into key counseling practice activities are scant. This article provides an introduction to interrelated strategies for integrating the SDMH into client case conceptualizations and treatment plans. Descriptions of core assumptions and activities are provided with examples depicting key areas of opportunity.
Assessment of a modified MINDS‐based protocol for management of alcohol withdrawal syndrome on an inpatient medical service
Authors: Krcmarik Kevin M. , Hulley Benjamin J. , Huang Jiayi , Juang Derek , Cadman Peter , Urbiztondo Charisma , Vo Christine , Vargas Jaclyn , Motarjemi Ramin , Moinizandi Tarlan , Kwan Brian 
Published: July 2023

AbstractObjectiveTo determine if a novel symptom‐based alcohol withdrawal syndrome (AWS) protocol in a US Veterans cohort leads to significant clinical improvements in patient outcomes and safety.BackgroundPrior studies of AWS management, oftentimes using the revised version of the Clinical Institute Withdrawal Assessment for Alcohol (CIWA‐Ar) index, have demonstrated the effectiveness of symptom‐triggered therapy for AWS. The Minnesota Detoxification Scale (MINDS) is an alternative to the CIWA‐Ar index but remains unevaluated outside of the intensive care unit (ICU) setting. This study assesses outcomes in AWS management prior to and after the implementation of a novel MINDS‐based AWS protocol (SDAWP) utilizing a revised MINDS index (MINDS‐rev) in an inpatient medical ward setting.MethodsRetrospective cohort study including encounters prior to (n = 342) and after (n = 338) the implementation of the protocol. Pre‐ and post‐protocol encounters were selected by combinations of diagnostic codes and charting elements. Outcome measures of AWS management were obtained in both groups. The primary endpoint was median total benzodiazepine exposure. Secondary outcomes included median length of hospitalization, median duration of benzodiazepine administration, and the incidence of complications.ResultsThe median total benzodiazepine exposure in the post‐SDAWP group was significantly lower than the pre‐SDAWP group (21.2 vs. 12.0 mg, p < 0.0001) and for a significantly shorter median duration of time (4.0 vs. 3.0 days, p < 0.0001). There was no significant difference in the median length of stay (4.0 vs. 4.0 days, p = 0.50). The incidence of delirium tremens (21 vs. 7, p = 0.01) and need for transfer to a higher level of care (33 vs. 12, p = 0.002) was significantly lower in the post‐SDAWP group.ConclusionThe SDAWP has provided significant improvements in AWS management in our institution and may potentially serve as a template for wider use in other inpatient settings.
In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A
Authors: Cholette Jill M. , McRae Hannah L. , Angona Ron , Cahill Christine , Swartz Michael F. , Alfieris George M. , Refaai Majed A. 
Published: July 2023

Cell saver blood is typically washed with normal saline (NS); however, recent studies have reported decreased red blood cell hemolysis and increased platelet function when a more physiologic washing solution, such as Plasma-Lyte A (PL-A) is used. We evaluated the in vitro and in vivo effects of NS compared to PL-A as washing solutions for cell saver blood in pediatric cardiac surgery. Cell saver blood was re-infused for up to 24 hours post-collection. Laboratory and clinical data were collected from infants receiving cell saver washed with either NS (n= 20) or PL-A (n= 21). Compositions of the cell saver blood were compared between groups at 5 in vitro time points and in vivo patient blood at 24 hours post-bypass. Although there were differences in in vitro laboratory values between groups; 24 hours post-bypass, in vivo results were similar. Our data supports 24-hour reinfusion of cell saver washed with either NS versus PL-A in pediatric cardiac surgery patients, and provides data on the differences in cell saver composition to guide future studies.
An adaptable, user-friendly score sheet to monitor welfare in experimental fish
Authors: Flueck-Giraud Mathilde , Schmidt-Posthaus Heike , Bergadano Alessandra , Adrian-Kalchhauser Irene 
Published: July 2023

AbstractFish are increasingly used as experimental animals across research fields. Currently, a quarter of all experimental animals used in Europe are fish. Less than 20% of these are standard model species. Welfare assessments for experimental fish are in their infancy compared to rodents. This can be attributed to the diversity of species used, the relative recency of fish as go-to model for research, and challenges to assess welfare and pain in non-vocal underwater species. The lack of guidelines and tools presents a challenge for researchers (particularly, for newcomers), for ethics committees, and for implementing refinement measures.Here, we present an adaptable, user-friendly score sheet for fish. The parameters contained in the excel tool are based on a literature review, have been validated by expert interviews, and evaluated by a fish pathologist. The tool allows to score individuals as well as groups, calculates summary scores and visualizes trends. We provide the underlying literature, give use examples and provide instructions on the adaptation and use of the score sheet.We hope that this tool will empower researchers to include welfare assessment in their routines, foster discussions on fish welfare parameters among scientists, facilitate interactions with ethics committees, and most importantly, enable the refinement of fish experiments.
Rethinking education, rethinking society
Authors: Kitcher Philip 
Published: July 2023

AbstractWhat should education aim to accomplish? What are its goals and how should it attempt to achieve them? Much excellent work, by philosophers and by policymakers, takes for granted the institutions and practices devised in the past. Yet, from time to time, it is important to stand back and to think more generally, to pose larger questions. My book, The Main Enterprise of the World, is written in that spirit.
Family perspectives of ex situ heart perfusion
Authors: Conway Jennifer , Deschenes Sadie , Pidborochynski Tara , Freed Darren H. , van Manen Michael 
Published: July 2023

AbstractBackgroundPediatric patients awaiting a heart transplant have high waitlist mortality. Several strategies have been utilized to decrease waiting times, but a mortality risk still exists. New medical technologies may improve waiting times and associated mortality. Ex situ heart perfusion (ESHP) is one such technology, which can decrease the impact of cold ischemia on the donor heart and allow for a longer out‐of‐body time. Adoption of such technology in pediatric heart transplantation will require support from end users, including patient and families. The aim of this qualitative study was to report the perspectives of families with experience related to pediatric HTx toward ESHP.MethodsSemistructured interviews were conducted with 12 parents or guardians of children who were awaiting or received heart transplantation. Interviews were transcribed, and data were analyzed using qualitative content analysis.ResultsParticipants expressed varied awareness and knowledge of ESHP. Independent of their understanding of ESHP, all purported that ESHP was an excellent idea and that this technology should be implemented in the pediatric population. They did not identify fundamentally different ethical issues or concerns for ESHP being used relative to other medical technologies. Overall, most participants described consent processes for ESHP should be like any other procedure. All agreed that the surgeon should continue to describe the overall health of the donor heart, provide their medical recommendations, and allow families to have the final say.ConclusionsThe concepts described by the parents and guardians are important in moving this novel technology forward. This information will serve the basis for knowledge translation that will provide educational resources to broaden the understanding and reach of ESHP.
On semigroups of transformations that preserve a double direction equivalence
Authors: Chen Hui , Liu Xin , Wang Shoufeng 
Published: July 2023

AbstractFor a non-empty setXX, denote the full transformation semigroup onXXbyT(X)T\left(X)and suppose thatEEis an equivalence relation onXX. Evidently,TE∗(X)={α∈T(X)∣(x,y)∈Eif and only if(xα,yα)∈Efor allx,y∈X}{T}_{{E}^{\ast }}\left(X)=\left\{\alpha \in T\left(X)| \left(x,y)\in E\hspace{0.33em}\hspace{0.1em}\text{if and only if}\hspace{0.1em}\hspace{0.33em}\left(x\alpha ,y\alpha )\in E\hspace{0.33em}\hspace{0.1em}\text{for all}\hspace{0.1em}\hspace{0.33em}x,y\in X\right\}is a subsemigroup ofT(X)T\left(X). In this article, we investigate Green relations, Green∗\ast-relations and Green∼\sim-relations, various kinds of regularities,ℱ{\mathcal{ {\mathcal F} }}-abundant andG{\mathcal{G}}-abundant elements and left and right magnifying elements inTE∗(X){T}_{{E}^{\ast }}\left(X). More specifically, we first obtain the necessary and sufficient conditions under whichℒ{\mathcal{ {\mathcal L} }}(respectively,ℒ∗{{\mathcal{ {\mathcal L} }}}^{\ast },ℒ˜\widetilde{{\mathcal{ {\mathcal L} }}},ℛ{\mathcal{ {\mathcal R} }},ℛ∗{{\mathcal{ {\mathcal R} }}}^{\ast }, andℛ˜\widetilde{{\mathcal{ {\mathcal R} }}}) is (left, right) compatible,ℛ=ℛ∗{\mathcal{ {\mathcal R} }}={{\mathcal{ {\mathcal R} }}}^{\ast }orℒ=ℒ˜{\mathcal{ {\mathcal L} }}=\widetilde{{\mathcal{ {\mathcal L} }}}. Then, we give the sufficient and necessary conditions such thatTE∗(X){T}_{{E}^{\ast }}\left(X)is left regular (respectively, right regular, completely regular, intra-regular, and completely simple). Finally, we characterize theℱ{\mathcal{ {\mathcal F} }}-abundant (respectively,G{\mathcal{G}}-abundant) and left (respectively, right) magnifying elements inTE∗(X){T}_{{E}^{\ast }}\left(X).
Trends and Persistence in the Greenland Ice Sheet Mass
Authors: Caporale Guglielmo Maria , Gil-Alana Luis Alberiko , Sauci Laura 
Published: July 2023

Abstract
This paper examines trends and persistence in the Greenland ice sheet mass by applying fractional integration methods to a dataset constructed by Mankoff et al. (2020) on ice discharge for seven different regions of Greenland. The adopted empirical framework encompasses a wide range of stochastic processes and is informative about their dynamic and long-run properties. The main finding is that significant changes have occurred in the behaviour of the series of interest in recent years; more specifically, although a deterministic trend is not present, ice discharge in the various regions of Greenland has become a non-stationary, explosive process, with shocks having permanent effects. It appears that, as a result of global warming, the ice mass loss in Greenland has already reached a tipping point and become an irreversible process.
JEL Classification: C22; Q54