bluuebunny/crossref_metadata_2025_split huggingface dataset:
The southern Wyoming Laramide basin: implications for long-term tectonic control on uplift and subsidence
Authors: Minor Keith P. , Steel Ronald J. , Olariu Cornel , Wroblewski Anton F.-J. 
Published: June 2023

ABSTRACTAn evolving tectonic setting during the Late Cretaceous and Paleocene drove the dramatic transformation of southern Wyoming from a broad marine shelf setting to a series of lacustrine basins. Early dominant control of depositional patterns by flexural tectonics gave way to control by dynamic topography and Laramide-style deformation. The southern Wyoming region demonstrates how progressive partitioning by Laramide movements exerted increasingly dominant control on regional depositional patterns. It did this by creating a long-lived, Laramide uplift-bounded fluvial catchment and basin largely controlled by Laramide-driven subsidence. The Rock Springs and Rawlins uplifts underpinned the basin and exerted their influence in the subsurface. Episodes of Laramide-driven subsidence produced a series of embayments, including the large Rusty–Allen Ridge embayment and the very large deepwater Lewis embayment. The degree of eustatic control in the region would have been greatest at short time scales in the low coastal–shallow-marine settings, causing shoreline oscillations. Several long transgressive episodes followed relatively punctuated progradational periods of coastal-plain construction when supply was generally high from the thrust belt and surrounding uplifts. Laramide activity in the Paleocene led to enclosure of the fluvial basin and the development of a series of smaller marine embayments that mark the end of influence in the region by open and coastal marine processes.
Optimal Spectrum Granularity for Spectrally-efficient Elastic Optical Networks
Authors: UJJWAL UJJWAL 
Published: June 2023

Abstract
In this paper, we compute the optimal slot width which provides a good trade-off between the blocking probability and network cost to attain spectral and cost-efficient solution for the next generation optical networks. Here we have determined the blocking performance by varying the slot width from 50 GHz down to 1.5625 GHz followed by the estimation of the network cost by taking into account various network elements viz., transponder, node equipment’s (OXC, SSS, splitter/combiner) and optical amplifiers. Further, an evaluation of the trade-off between blocking performance and network cost is carried out to get the optimal slot width.
ADRC with Anti-Saturation for Uncertain HighADRC with Anti-Saturation for Uncertain High-Order Nonlinear MASs with Random Disturbances and Communication Delays
Authors: Wei Wenjun , He Zhizhen 
Published: June 2023

Abstract
This paper presents an Active Disturbance Rejection Consensus (ADRC) algorithm for high-order uncertain nonlinear multi-agent systems (MAS) with input saturation and time-varying communication delay in completely unknown perturbations. The proposed ADRC algorithm achieves dynamic consensus of MAS while simultaneously handling uncertain nonlinearity, external disturbance, communication delay, and input saturation of the system. The algorithm uses a linear extended state observer (LESO) to estimate the MAS's uncertain nonlinear terms and stochastic perturbations. Based on the estimated states, a distributed ADRC control law using a generalized saturation function is proposed to handle input saturation and communication delay, ensuring that all agents reach consensus. Furthermore, an upper bound on the delay of the MAS is given by using the generalized Lyapunov-Krasovskii function method, which provides the stability of the closed-loop system under a strongly connected and directed graph. Finally, numerical simulations are presented to demonstrate the effectiveness of the proposed strategy.
The “GU-GU-RU project” to eliminate discrimination related to the health effects of the Fukushima nuclear accident
Authors: Amir Isamu , Eguchi Yuichiro , Saotome Kosaku , Ogawa Soichiro , Kojima Yoshiyuki , Tamaki Tomoaki , Tsubokura Masaharu 
Published: June 2023

Abstract
Background: Although 12 years have passed since Great East Japan Earthquake and following Fukushima nuclear accident, approximately 40% of Japanese citizen still believe that the current radiation exposure in Fukushima residents will likely cause genetic effects of radiation. This misunderstanding could continue unexpected discrimination and prejudice towards those from Fukushima now and in the future. In order to provide updated knowledge and eliminate rumors related to radiation, Japanese Ministry of the Environment has launched “GU-GU-RU project” in 2021 with consisting of five sections.
Objective: To discuss the objectives and effects of the “GU-GU-RU Project” (results after the first year), to present administrative measures that may be effective in the long-term to prevent unjustified discrimination and prejudice, and to eliminate rumors in the event of future large-scale disasters, including radiation disasters.
Methods: We showed the contents of each sections carried out under the project and observed the result of first-year activities in each section.
Results: Among the programs, the “Radiation College” has steadily produced positive results, with nearly 1,300 students participating and 50 students sharing their thoughts and ideas. In addition, the project has adopted strategies such as creating and broadcasting a TV program and collaborations with manga, which are expected to have a significant impact on society.
Conclusions: Compared to previous efforts on disseminating information related to health effect of radiation exposure, the “GU-GU-RU Project” has taken a different approach in providing information of radiation and its health effects, which could become a better understanding of health effects of radiation for the general public.
Ejection of mitochondria mediates hypertonicity-induced adipocytes dedifferentiation
Authors: Liu Guopan , Wang Ying , Pan Yilin , Tian Li , Choi Ming Ho , Wang Li , Kim Jin Young , Cheng Shuk Han , ZHANG Liang 
Published: June 2023

Abstract
Background: Recent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to generate multipotent stem cells. Here we aim to elucidate the molecular mechanisms that underlie osmotic induction of adipocyte reprogramming.Methods: To induce dedifferentiation, the 3T3-L1 or SVF adipocytes were cultured under the hypertonic pressure in 2% PEG 300 medium. The dedifferentiation of adipocytes was monitored by aspect ratio measurement, Oil Red staining and qPCR to examine the morphology, lipid droplet sizes, and adipose-specific gene expression, respectively. The stem-cell capacity of dedifferentiated adipocytes was validated by osteogenic and chondrogenic differentiation. To elucidate the mechanism of the osmotic stress-induced dedifferentiation, the extracellular vesicles (EVs) were collected from the reprograming cells, followed by proteomic and functional analyses. To investigate the signaling mechanisms, qPCR was applied to assess the corresponding pathways and TNF-α neutralizing antibody (20ng/ml) was applied to counteract the effects of the TNF-α signaling. We also analyzed the Wnt signaling by assessing the activation of β-catenin and applying BML-284 that activates β-catenin to induce the multipotent adipocyte dedifferentiation.Results: We report that hypertonicity induces mitochondrial stress and prompts the adipocytes to eject mitochondrial components through extracellular vesicles, which we term mitochondrial EVs (MEVs). Importantly, we showed that MEVs function in an autocrine fashion to enhance the pro-inflammatory TNF-α signaling that activates β-catenin and drives adipocyte dedifferentiation. Alleviating mitochondrial stress inhibited MEVs release and hypertonicity-induced adipocyte dedifferentiation. In addition, we also observed increased apoptosis of adipocytes as a potential caveat of hypertonicity-induced adipocyte dedifferentiation. To circumvent this, we showed that BML-284, a small compound that directly activates the Wnt/β-catenin signaling could effectively promote multipotent adipocyte dedifferentiation without inducing apoptosis.Conclusions: Hypertonicity prompts the adipocytes to release MEVs, which in turn enhances the secretion of TNF-α as a pro-inflammatory cytokine during the stress response. Importantly, TNF-α is essential for the activation of the Wnt/β-catenin signaling that drives adipocyte dedifferentiation. A caveat of the hypertonic treatment is apoptosis, which could be circumvented by direct activation of the Wnt/β-catenin signaling using BML-284.
Scale-dependent Power Law Properties in Hashtag Usage Time Series of Weibo
Authors: Jiang Jiwei J. , Yamada Kenta , Takayasu Hideki , Takayasu Misako 
Published: June 2023

Abstract
We analyze the time series of hashtag numbers of social media data. We observe that the usage distribution of hashtags is characterized by a fat-tailed distribution with a size-dependent power law exponent and we find that there is a clear dependency between the growth rate distributions of hashtags and size of hashtags usage. We propose a generalized random multiplicative process model with a theory that explains the size dependency of the fat-tailed distribution. Numerical simulations show that our model reproduces these size-dependent properties nicely. We expect that our model is useful for understanding the mechanism of fat-tailed distributions in various fields of science and technology.
The Secondary Somatosensory Cortex Gates Mechanical and Thermal Sensitivity
Authors: Woolf Clifford , Taub Daniel , Jiang Qiufen , Pietrafesa Francesca , Su Junfeng , Greene Caitlin , Jain Aakanksha , He Zhigang , Chen Chinfei , Callen Alexis , Yager Katherine , Blanchard Michael , El-Rifai Mahmoud , Chung Clara 
Published: June 2023

Abstract
The cerebral cortex is vital for the perception and processing of sensory stimuli. In the somatosensory axis, information is received by two distinct regions, the primary (S1) and secondary (S2) somatosensory cortices. Top-down circuits stemming from S1 can modulate mechanical and cooling but not heat stimuli such that circuit inhibition causes blunted mechanical and cooling perception. Using optogenetics and chemogenetics, we find that in contrast to S1, an inhibition of S2 output increases mechanical and heat, but not cooling sensitivity. Combining 2-photon anatomical reconstruction with chemogenetic inhibition of specific S2 circuits, we discover that S2 projections to the secondary motor cortex (M2) govern mechanical and thermal sensitivity without affecting motor or cognitive function. This suggests that while S2, like S1, encodes specific sensory information, that S2 operates through quite distinct neural substrates to modulate responsiveness to particular somatosensory stimuli and that somatosensory cortical encoding occurs in a largely parallel fashion.
Online triplet contrastive learning enables efficient cliff awareness in molecular activity prediction
Authors: Shen Wan Xiang , Cui Chao , Shi Xiang Cheng , Zhang Yan Bing , Wu Jie , Chen Yu Zong 
Published: June 2023

Abstract

Predicting molecular activity and quantitative structure-activity relationship (QSAR) is important for drug discovery and optimization. With molecular structures as frames, graph neural networks (GNNs) are suited for activity prediction but tend to overlook activity-cliffs (ACs) where structurally-similar molecules have vastly different activity values. To address this, we introduced a new online triplet contrastive learning framework ACANet that incorporates a unique activity-cliff-awareness (ACA) loss function, enabling efficient AC-awareness during training. The ACA loss enhances metric learning in the latent space and task learning in the target space simultaneously to make networks aware of ACs. ACANet outperformed the state-of-the-art machine learning and deep learning models in activity prediction and AC awareness on 39 benchmark datasets. ACA loss function is superior in AC-awareness than the mean absolute error and mean squared error loss functions. This innovative approach opens new avenues and provides valuable tools for applications in drug discovery and chemical engineering.
Multimodal imaging and deep learning unveil pulmonary delivery profiles and acinar migration of tissue-resident macrophages in the lung
Authors: Yang Lin , Kumar Pramod , Sengupta Arunima , Farnoud Ali , Shen Ruolin , Trofimova Darya , Ziegler Sebastian , Davoudi Neda , Doryab Ali , Yildirim Ali , Schiller Herbert , Razansky Daniel , Piraud Marie , Liu Qiongliang , Rehberg Markus , Stoeger Tobias , Burgstaller Gerald , Kreyling Wolfgang , Isensee Fabian , Schmid Otmar 
Published: June 2023

Abstract
Holistic deciphering of spatially-resolved delivery and biokinetics of nanoparticles (NPs) in the lung, along with the mobility of tissue-resident macrophages (TRMs) and their role in regulating NP cellular fate, remains unclear. Multimodal imaging and deep learning were applied to elucidate the longitudinal inter- and intra-acinar deposition features and regional dosimetry of NPs. The initial NP distribution patterns depended significantly on the pulmonary delivery routes and were most uniform for aerosol inhalation. Artificial intelligence-driven 3D airway segmentation enabled direct determination of bronchial and acinar NP dose. Longitudinal imaging uncovered an intra-acinar NP kinetics profile independent of delivery route. Contrary to the traditional notion of passive diffusion, this study reveals that long-term NP lung retention is facilitated by intra-acinar NP transport mediated by phagocytosis and patrolling of TRMs. Overall, this study elucidates the complexities of NP-lung delivery features and TRM immunity on the fate of biopersistent NPs.
Will antibody-drug conjugate and immune checkpoint inhibitor-based combination therapy close the gap between benefit and toxicity in the treatment of cancers? A systematic review and meta-analysis
Authors: Zhang Leyin , Yan Yici , Chen Yixin , Lu Jiamin , Wang Binbin , Ren Ning , Sun Leitao 
Published: June 2023

Abstract
Background
Although antibody-drug conjugate (ADC) fosters hope for the treatment of cancer, the effect of single drug treatment is limited. Therefore, to achieve wider therapeutic effects, the combination of ADC and Immune checkpoint inhibitors (ICI) therapy may hold potential.
Methods
After literature retrieval, screening and data extraction, quality assessment was done by two investigators. Then, overall response rate (ORR) and adverse effects (AEs) were evaluated to study its efficiency and safety. Publication bias was also calculated through Funnel plot, Begg's Test and Egger's test. Meanwhile, heterogeneity was investigated through subgroup and sensitivity analysis.
Results
11 eligible clinical studies with a total sample size of 551 were included. The pooled ORR was 59% (95% CI: 45% − 72%), especially in patients with relapsed classical Hodgkin lymphoma and patient treated with Brentuximab vedotin + Pembrolizumab. The most common AEs was peripheral neuropathy (38.2%) and AEs on skin (13.1% − 18.5%) and digestive system (8.7% − 28.1%) can not be overlooked.
Conclusion
ADC + ICI therapy may be recommended in cancer treatment, whereas strategies to manage toxicities warranted further exploration (PROSPERO CRD42023375601).
Quantifying subnational climate change mitigation solutions - a meta-analysis of impacts
Authors: Song Kaihui , Yeo Zhi Yi , Johnson Evan , Hsu Angel , Farr Katherine Burley 
Published: June 2023

Abstract
Although the potential for cities and regions to contribute to global mitigation efforts is widely acknowledged, there is little evidence on the effectiveness of subnational mitigation strategies. We address this gap through a systematic review of 234 quantitative mitigation case studies. We use a meta-analytical approach to estimate expected greenhouse gas emissions reductions from 12 categories of mitigation strategies. We find that strategies related to land use and development, circular economy, and waste management are most effective and reliable for reducing emissions. The results demonstrate that cities and regions are taking widespread action to reduce emissions. However, we find misalignment between the strategies that policymakers and researchers focus on, compared to those with the highest expected impacts. The results inform climate action planning at the city and regional level and the evaluation of subnational climate targets.
Assessment of combining ability and gene action for seed cotton yield and fibre quality traits in Lintless-Fuzzless genotypes of upland cotton (Gossypium hirsutum. L)
Authors: LATHA ANANDA LEKSHMI , MAHADEVAN KUMAR , SIVAKAMI RAJESWARI , MUTHURAJAN RAVEENDRAN , DORAISWAMY UMA , SADASIVAM MANICKAM 
Published: June 2023

Abstract
Background
Knowledge of genetic diversity is the prerequisite to choose the parents for heterosis breeding aimed at the improvement of any trait in cotton as hybridization among the accessions belonging to diverse genetic background exhibited desirable recombinants in segregating generation. Understanding the genetic behaviour of lint and fuzz formation in cotton is crucial for improving cotton production and developing new cotton varieties with desired traits.
Result
The current study was intended to evaluate the genetic diversity among different fuzzy and fuzzless genotypes and to understand the gene action and combining ability of seed cotton yield and yield contributing characters along with fibre quality. Principal component analysis revealed that the first four principal component analyses (PCs) out of the total eleven PCs exhibited higher eigen values (> 1) and had maximum contribution to total variability (89.46%). The attributes that had maximum share to total divergence included number of bolls per plant, number of sympodia, ginning out turn, elongation percentage, uniformity index, fibre length, fibre strength, days to first boll opening and days to fifty percent flowering. Line x Tester mating design was used to develop 36 hybrids. Study of biometrical traits revealed that the dominance variance was higher than the additive variance in both the sets. Considering the per se performance and gca effects, CO 14 and CO17 were found to be elite general combiners for yield and fibre quality traits which can be further utilized as parents in breeding programme. The hybrids with high sca effects in the desired direction were TCH1646 / CO17 and MCU5 / AKH9881 which showed best performance for yield and yield contributing traits.
Conclusion
It is quite important to breed new genotypes that have no fuzz on the seed and higher gin turnout. Fuzzless but fibery genotypes might be utilized to reach this goal. Seed cotton yield and its contributing characters were controlled non additively and hence hybrid breeding is the best choice for crop improvement.
Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loading
Authors: Wasser Catherine , Werthmann Gordon C. , Hall Eric M , Kuhbandner Kristina , Wong Connie H , Durakoglugil Murat S , Herz Joachim 
Published: June 2023

AbstractBackgroundApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain, Reelin potentiates excitatory synapses and thereby protects against amyloid-β toxicity. Recently, a gain-of-function mutation in Reelin that is protective against early-onset AD has been described. Alternative splicing of the Apoer2 intracellular domain (Apoer2-ICD) regulates Apoer2 signaling. Splicing of juxtamembraneous exon 16 alters the g-secretase mediated release of the Apoer2-ICD as well as synapse number and LTP, and inclusion of exon 19 ameliorates behavioral deficits in an AD mouse model. The Apoer2-ICD has also been shown to alter transcription of synaptic genes. However, the role of Apoer2 splicing for transcriptional regulation and its role in AD pathogenesis is unknown.MethodsTo assessin vivomRNA-primed ribosomes specifically in hippocampi transduced with Apoer2-ICD splice variants, we crossed wild-type, cKO, and Apoer2 cleavage-resistant mice to a Cre-inducible translating ribosome affinity purification (TRAP) model. This allowed us to perform RNA-Seq on ribosome-loaded mRNA harvested specifically from hippocampal cells transduced with Apoer2-ICDs.ResultsAcross all conditions, we observed ~ 4,700 altered ribosome-associated transcripts, several of which comprise key synaptic components such as extracellular matrix and focal adhesions with concomitant perturbation of critical signaling cascades, energy metabolism, translation, and apoptosis. We further demonstrated the ability of the Apoer2-ICD to rescue many of these altered transcripts, underscoring the importance of Apoer2 splicing in synaptic homeostasis. A variety of these altered genes have been implicated in AD, demonstrating how dysregulated Apoer2 splicing may contribute to neurodegeneration.ConclusionsOur findings demonstrate how alternative splicing of the APOE and Reelin receptor Apoer2 and release of the Apoer2-ICD regulates numerous ribosome-associated transcripts in mouse hippocampiin vivo. These transcripts comprise a wide range of functions, and alterations in these transcripts suggest a mechanistic basis for the synaptic deficits seen in Apoer2 mutant mice and AD patients. Our findings, together with the recently reported AD-protective effects of a Reelin gain-of-function mutation in the presence of an early-onset AD mutation in Presenilin-1, implicate the Reelin/Apoer2 pathway as a target for AD therapeutics.
Financial Literacy and Consumption Inequality of Chinese Households—Evidence from CHFS Data
Authors: Chen Qinghua , Kang Xiuhua , Wang Yuzhi 
Published: June 2023

Abstract
Common prosperity is the foundation for the steady development and growth of the economy. And alleviating consumption inequality in households is crucial for achieving common prosperity. The mechanisms of financial literacy as human capital to alleviate consumption inequality still need to be determined. Therefore, we theoretically analyzed the relationship between financial literacy on household consumption inequality. And then the Kakwani consumption relative deprivation index was employed to measure household consumption inequality based on the panel data from CHFS in 2017 and 2019. We utilized the instrumental variable approaches to overcome the endogeneity problems. The results showed that improving household financial literacy mitigated the consumption inequality of households, especially for development and enjoyment consumption. Financial literacy affected consumption inequality by the mediating effects of alleviating household liquidity constraints, optimizing asset allocation, and mitigating income inequality. It offers a promising way to help household consumption inequality and achieve common prosperity.