bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary splenic diffuse large B‐cell lymphoma presenting as a splenic abscess
Authors: Wadsworth Paul A. , Miranda Roberto N. , Bhakta Pooja , Bhargava Peeyush , Weaver Dylan , Dong Jianli , Ovechko Vasily , Norman Michael , Muthukumarana Palawinnage V. , Bayes Mathew G. , Mallick Jayati , Lyapichev Kirill A. 
Published: January 2023

AbstractDiffuse large B‐cell lymphoma (DLBCL) arising in the spleen, also known as primary splenic DLBCL (PS‐DLBCL), is a rare form of malignant lymphoma. It is defined as a lymphoma confined to the spleen or involving splenic hilar lymph nodes. Here we report a case of PS‐DLBCL with CD30. The patient was a 62‐year‐old who presented with 2 weeks of left flank pain, chills, and abdominal distension. Computed tomography identified an 8‐cm splenic mass with central necrosis interpreted as an abscess. A drain was placed, yielding purulent necrotic material; cytologically, only neutrophils were identified. However, purulent drainage continued for 28 days without resolution, prompting splenectomy. Pathological dissection revealed a multinodular mass with central necrosis. Microscopic examination revealed extensive karyorrhexis, abundant ghosts of large cells, and scattered large cells with pleomorphic, multilobated, and vesicular nuclei with moderately abundant cytoplasm. Immunohistochemical staining revealed large, atypical cells positive for CD20, CD30, CD45, PAX5, MYC (>40%), MUM1 (>30%), and p53 (focally). The large cells were negative for CD3 (polyclonal), CD4, CD5, CD8, CD10, CD15, CD34, BCL2, BCL6, AE1/AE3, S100, HHV8, and ALK. The Ki‐67 proliferation rate was approximately 80% in large cells. Notably, this PS‐DLBCL was positive for CD30, an unusual finding among non‐Hodgkin B‐cell lymphomas, which, coupled with the Reed‐Sternberg‐like morphology, raised the possibility of classic Hodgkin lymphoma. Therefore, we reviewed the literature to confirm the unique features of this large B‐cell lymphoma, its abscess‐like appearance, and its expression of CD30.
The effect of customer and supplier concentrations on firm resilience during the COVID‐19 pandemic: Resource dependence and power balancing
Authors: Jiang Shenyang , Yeung Andy C. L. , Han Zhaojun , Huo Baofeng 
Published: January 2023

AbstractThe COVID‐19 pandemic has created significant disruptions in both demand and supply. Our study makes use of such dramatic changes in demand and supply during the pandemic to examine resource dependence and power balancing/unbalancing issues in buyer–supplier relationships. Specifically, we investigate the effect of customer and supplier concentrations on firm resilience during the pandemic. Drawing on resource‐dependence theory (RDT), we theorize that shifts in demand and supply in different pandemic stages influence the effect of customer and supplier concentrations on firm resilience by altering the power dynamics between focal firms and their concentrated customers and suppliers. Central to our theorizing is that the worsening power imbalance is more detrimental. Measuring firm resilience by loss and recovery (i.e., change) in productivity, our analysis of 23,440 Chinese listed firms' quarter observations from 2019 to 2020 shows that customer concentration is negatively related to firm resilience in the disruption stage but has no effect in the restoration stage. Supplier concentration is positively related to firm resilience in the disruption stage but undermines firm resilience in the restoration stage. These findings largely confirm our theoretical propositions. We discuss the theoretical and managerial implications.
Purification and characterization of Taxol and 10‐Deacetyl baccatin III from the bark, needles, and endophytes of Taxus baccata by preparative high‐performance liquid chromatography, ultra‐high‐performance liquid chromatography‐mass spectrometry, and nuclear magnetic resonance
Authors: Nurullah Md. , Usmani Zakiya , Ahmad Sheeraz , Panda Bibhu Prasad , Amin Saima , Mir Showkat Rasool 
Published: January 2023

Taxol and 10‐Deacetyl baccatin III are major taxanes in the bark, needles, and endophytes of Taxus baccata. The current study aimed to develop a process for their separation from different matrices. Crude taxoid was prepared by extraction of samples with methanol, followed by partitioning with dichloromethane and precipitation with hexane. Analytical high‐performance liquid chromatography involved isocratic elution on C18 column (4.6 × 250 mm, 5 μm) with methanol‐water (70:30 v/v) at a flow rate of 1 ml/min. Injection volume was 20 μl and detection was carried out at 227 nm. The content of Taxol and 10‐Deacetyl baccatin III in bark, needles and endophytic culture broth was 11.19 and 1.75 μg/mg; 11.19 and 1.75 μg/mg; and 2.80 and 0.22 μg/L, respectively. Preparative high‐performance liquid chromatography was done on C18 column (10 × 250 mm, 5 μm) at a flow rate of 10 ml/min. About 20 g crude taxoid was processed in < 3 h with a recovery of about 90% for both the analytes. The purity of recovered Taxol and 10‐Deacetyl baccatin III determined by ultra‐high‐performance liquid chromatography‐mass spectrometry was found to be 95.78 ± 3.63% and 99.72 ± 0.18%, respectively. The structure of recovered Taxol was confirmed by nuclear magnetic resonance. The method can find use in biotransformation studies.
The impact of introducing hydrodistension as a treatment for frozen shoulder in a primary care musculoskeletal service: A retrospective audit
Authors: Whelan Gareth , Yeowell Gillian , Littlewood Chris 
Published: January 2023

AbstractIntroductionHydrodistension, where a relatively high volume of local anaesthetic, corticosteroid, and sterile saline are injected into the shoulder joint, is a treatment of interest for frozen shoulder. In the UK National Health Service this is typically provided in the hospital setting. In 2017 we introduced hydrodistension into our physiotherapy led musculoskeletal service. This report describes the findings from our audit of onward referral for orthopaedic assessment following the introduction of hydrodistension to our frozen shoulder treatment pathway.MethodsA retrospective audit of data from 102 patients who followed our hydrodistension treatment pathway for frozen shoulder since 2017 was conducted. All 102 patients received at least one hydrodistension procedure performed by a physiotherapist. This involved injecting the glenohumeral joint with a combination of local anaesthetic, corticosteroid, and saline under ultrasound guidance with a total volume of 25–35 mls. This data was compared to the outcomes of 102 patients who presented with frozen shoulder prior to 2017 who did not receive hydrodistension.ResultsOf 102 patients who received hydrodistension within the musculoskeletal service, six patients required onward referral to orthopaedics. Of the 102 patients who did not receive hydrodistension prior to 2017, 58 required onward referral to orthopaedics.ConclusionWe report a reduction in onward referral to orthopaedics following the introduction of hydrodistension to our physiotherapist‐led treatment pathway for patients with frozen shoulder. This preliminary data identifies the need to further evaluate the clinical and cost‐effectiveness of hydrodistension performed by physiotherapists for patients with frozen shoulder.
Obesity among African American people in the United States: A review
Authors: Lofton Holly , Ard Jamy D. , Hunt Rameck R. , Knight Michael G. 
Published: January 2023

AbstractObesity is a growing public health crisis in the United States and is associated with a substantial disease burden due to an increased risk for multiple complications, including cardiovascular and metabolic diseases. As highlighted in this review, obesity disproportionately affects the African American population, women in particular, regardless of socioeconomic status. Structural racism remains a major contributor to health disparities between African American people and the general population, and it limits access to healthy foods, safe spaces to exercise, adequate health insurance, and medication, all of which impact obesity prevalence and outcomes. Conscious and unconscious interpersonal racism also impacts obesity care and outcomes in African American people and may adversely affect interactions between health care practitioners and patients. To reduce health disparities, structural racism and racial bias must be addressed. Culturally relevant interventions for obesity management have been successfully implemented that have shown benefits in weight management and risk‐factor reduction. Strategies to improve health care practitioner–patient engagement should also be implemented to improve health outcomes in African American people with obesity. When managing obesity in African American people, it is critical to take a holistic approach and to consider an individual's social and cultural context in order to implement a successful treatment strategy.image
Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models
Authors: Lu Yanli , Yuan Wanwan , Xiong Xiaowei , Huang Qianqian , Chen Sheng , Yin Tingting , Zhang Yanan , Wang Zhie , Zeng Guohua , Huang Qiren 
Published: January 2023

AbstractObjectiveThe aim of the study was to investigate the contribution of asprosin (ASP), a fasting‐induced hormone involved in metabolic disorders, to vascular endothelial dysfunction in obesity models.MethodsPrimary rat thoracic aortic endothelial cells treated with palmitic acid and mice fed with a high‐fat diet (HFD) were used as the obesity models. The role and mechanism of ASP in endothelial dysfunction were investigated by the means of morphologic, functional, and genetic analysis.ResultsASP aggravated the endothelial dysfunction induced by either palmitic acid in vitro or an HFD in vivo, characterized as the impairment of endothelium‐dependent vasodilation, reduction of nitric oxide levels, elevation of malondialdehyde levels, and inhibition of phosphoinositide 3‐kinase–AKT–endothelial nitric oxide synthase signaling. However, adipose conditional knockout of ASP or ASP neutralization significantly alleviated the endothelial dysfunction induced by an HFD. Mechanistically, ASP enhanced mitochondrial fission, and inhibition of the fission through knockdown of dynamin‐related protein 1 (a fission‐hallmark factor) rescued the endothelial dysfunction and the disturbance to mitochondrial dynamics induced by ASP.ConclusionsThe findings demonstrate that ASP causes and even exacerbates vascular endothelial dysfunction through promoting mitochondrial fission in obesity, suggesting that ASP can act as an early predictive marker of blood vessel dysfunction and become a novel potential therapeutic target for obesity‐related cardiovascular diseases.
Design of encapsulation method for chlorogenic acid and caffeine in coffee waste by‐product
Authors: Cosgun Gulderen , Gungor Keziban Kubra , Balci‐Torun Ferhan , Sahin Selin , Torun Mehmet 
Published: January 2023

AbstractIntroductionCoffee silver skin (CSS) is a thin covering over green coffee seeds inside coffee cherry. It is a good source of bioactive compounds like chlorogenic acid and caffeine. It is produced as a by‐product of the roasting process.ObjectiveThe goal of this study is to apply spray drying method to encapsulate 5‐O‐caffeoylquinic acid (chlorogenic acid) and caffeine extracted from CSS.MethodsThe main‐plots for optimisation were feed solid concentration (2.5, 5, 10°Bx), and the sub‐plots of the whole‐plot were carrier material type (maltodextrin, modified starch, arabic gum) and inlet air temperature (130, 160, 190°C). Responses included were drying yield, chlorogenic acid concentration, caffeine content, Carr index, and solubility values.ResultsSuitable conditions were spray drying inlet temperature of 190°C, extract concentration of 10°Bx, and wall material composition [modified starch/arabic gum (MS:AG)] 10.5:9.5. As the feeding CSS extract concentration increased, the amount of chlorogenic acid and caffeine in the final powder increased, while the powder's flow characteristics improved.ConclusionsThe concentration stage might be used to produce free‐flowing powdered particles with good bioactive retention for use in the food processing industry.
Effectiveness of spinal manipulation in addition to pharmacological treatment in fibromyalgia: A blinded randomized trial
Authors: Ince Bugra , Kara Mert , Erdem Irem , Yurdakul Ozan Volkan , Erden Tunay , Aydın Teoman 
Published: January 2023

AbstractBackgroundIt has been suggested that spinal manipulation may alter sensorimotor integration in the central nervous system and therefore may be used to treat central sensitization syndromes.ObjectiveTo investigate the effectiveness of spinal manipulation in addition to pharmacological treatment in patients with fibromyalgia.DesignA single‐center, randomized, and placebo‐controlled trial with three parallel armsSettingOutpatient clinics at a tertiary health care facility.ParticipantsFemale patients aged 18‐55 years receiving pharmacological treatment.InterventionsSpinal manipulation, sham manipulation, and control groups. Patients in the spinal manipulation group received high‐velocity low‐amplitude manipulation treatment twice a week for 3 weeks. Patients in the sham group received an application that was very similar to the active treatment but was not expected to have any real therapeutic effect. Patients in the control group continued to receive pharmacological therapy.Main Outcome MeasuresThe primary outcome, pain score (visual analog scale), and secondary outcomes, pressure pain threshold (PPT), Revised Fibromyalgia Impact Questionnaire (FIQR), Widespread Pain Index (WPI), and Fibromyalgia Severity Score (FSS) were measured before, 1 month, and 3 months after randomization.ResultsSixty patients with a mean age of 41.7 years (SD = 8.0) were enrolled in the study. A mixed‐design repeated analysis of covariance was used to test the data. At 1 month after randomization, pain scores did not differ between groups. At 3 months after randomization, the spinal manipulation group had a significantly lower pain score (adjusted mean = 4.3 cm, SE: 0.4) than the control group (adjusted mean = 6.8 cm, SE: 0.4) and the sham manipulation group (adjusted mean = 5.7 cm, SE: 0.4). PPT did not differ between groups at any time point. FIQR, WPI, and FSS showed some improvement 1 or 3 months after randomization in favor of the spinal manipulation group.ConclusionsSpinal manipulation used in addition to pharmacological treatment in young/middle‐aged female patients with fibromyalgia could be an effective treatment for pain, disease severity, and functionality.
Inhibitory effect of extracts of hainosan (painongsan) and its constituent crude drugs on production of monocyte chemoattractant protein‐1 and interleukin‐6 in murine fibroblasts treated with Porphyromonas gingivalis
Authors: Minami Masaaki , Taira Masayo , Makino Toshiaki 
Published: January 2023

AbstractAimHainosan (painongsan), composed of Platycodon grandiflorum root (PG), Paeonia lactiflora root (PL), and Citrus aurantium immature fruit (AF), is a formula used in traditional Japanese (Kampo) and Chinese medicine to treat purulent diseases, including gingivitis. In this study, we investigated the anti‐inflammatory effects of hainosan extract (HNS) using both traditional direct and serum pharmacological techniques.MethodsBALB/c mice were orally treated with HNS or extracts of its constituent crude drugs for one week. Murine RCB2767 fibroblasts were incubated with a medium containing heat‐killed Porphyromonas gingivalis and HNS, extracts of the constituent crude drugs, or serum samples collected from mice orally treated with these extracts. The monocyte chemoattractant protein 1 (MCP‐1) and interleukin (IL)‐6 in the medium were measured by enzyme‐linked immunosorbent assay (ELISA). The effect of HNS and its constituent crude drugs on the proliferative potential of fibroblasts was evaluated by radioisotope‐labeled thymidine uptake capacity.ResultsThe concentrations of MCP‐1 and IL‐6 in the culture supernatants were significantly increased by treatment with heat‐killed bacteria. In addition, PG and PL extracts significantly inhibited MCP‐1 and IL‐6 production. Furthermore, supplementation of serum samples from mice orally treated with the extracts to the culture medium resulted in significant inhibition of induction of these cytokines. HNS, extracts of PG, PL and AF, and serum samples collected from mice treated with these extracts significantly augmented 3H‐thymidine uptake in fibroblasts.ConclusionOur results demonstrated that HNS has anti‐inflammatory effects in murine fibroblasts and that PL and PG could contribute to the effects of hainosan.
Engaging individuals living with dementia as stakeholders
Authors: Moreno Monica , Kline Chelsea , Shubeck Emily , Lanigan Kerry , Fazio Sam 
Published: January 2023

AbstractThe Alzheimer's Association has been convening individuals living with dementia as stakeholders for nearly 2 decades. This article outlines the evolution of, and lessons learned from, the Association's leadership in stakeholder engagement. It will also highlight the contributions of the Association's Early Stage Advisory Group in the areas of public policy, programming and resources, medical and scientific advancements, and public awareness. In addition, this article will discuss the ways in which the research community has come to recognize the importance of including the voices of persons living with dementia in their work and has looked to the Association for guidance and leadership. Last, it will describe the future directions of the Association with regard to increasing the influence and profile of these key stakeholders.
Ethical Considerations in Gamified Interactive Marketing Praxis
Authors: Al-Msallam Samaan , Xi Nannan , Hamari Juho 
Published: January 2023

AbstractGamification with various designs is becoming a mainstay of interactive marketing, used to pervasively and holistically to in value-creating marketing practices. Beyond marketing, gamification is commonly seen as a technology, the effects of which are benevolent and which is often employed for sustainable ends such as the improvement of wellbeing, health, and sustainable work. However, as gamification commonly, either more or less directly, is related to attempts at affecting customers’ psychological states and continued engagement, a critical reflection of the ethical ramifications of gamification is crucial. Hazards such as manipulation, exploitation, psychological distress, and conflicts with cultural norms are considered as potential challenges that should be observed. Nevertheless, there is a current lack of examination of gamification’s ethical implications in the marketing context. In this chapter, the authors explore the ethical concerns related to using gamification as an interactive marketing tool, and examine how consumers shape their ethical judgement towards gamification. The authors also suggest various ways to help marketers, designers, and policymakers to minimize the unethical consequences of gamification, and ensure that companies will use gamification to compete both ethically and responsibly.
La Mercadita 2050: Telling Tomorrows of a Market After Oil
Authors: Sol Cueva Lillian 
Published: January 2023

AbstractIn this chapter, I tell the story of La Mercadita, an imaginary Market located in Mexico City in the year 2050. This fictional story was inspired and informed by the visions of vendors, who created four stories about the future of their marketplaces and their energy systems, during my field research in Mexico City in 2020. It pulls together the wishes, dreams and fears vendors have while talking about the future; some of their concrete ideas that address energy transitions; and the implications these visions may have in their communities and environments. The chapter stories energy imaginaries from a feminist political ecology perspective in order to encourage FPE to explore narrative approaches and to build creatively on communities’ visions of their own futures.
The Territory of Our Body: A Conversation on Urban Environments in the Andes and Their Bodies
Authors: Solera Agustina , Ortecho Mariana Jesús 
Published: January 2023

AbstractIn this chapter, we dialogically intertwine meanings that flow between the Western and the Andean cultural horizons, in urban environments marked by coloniality. Attentive to different ways of establishing community, we evoke elements from the Andean worldview from a decolonial perspective, at times overlapping with feminist political ecology (FPE). By opening to the Andean way of understanding and feeling the relationship between the social and the natural, we rehearse answers to social and environmental crises.
Perspectives on Decoloniality for FPE
Authors: Ekowati Dian , Gómez Marlene , Monterroso Iliana , Shrestha Ankita 
Published: January 2023

AbstractIn this chapter, we engage some of our intimate understandings of decolonial thought. We reflect on aspects of our personal intellectual journeys and epistemic relationships with coloniality. Our aim is to be transparent with the reader about the ‘places we come from’ and to bring our multiple voices and perspectives underlying the different colonial realities we all live as researchers from the ‘global’ South. Our perspectives are therefore an outcome of thinking through decoloniality. We acknowledge that our individual and unique trajectories have shaped how we understand coloniality and how we subsequently attempt to decolonise our areas of research and ourselves, with the help of overlapping concepts (in feminist political ecology) of subjectivity, the body, and the other. Our aim is to expose our different interpretations as a necessary step to engaging, thinking about, and articulating thoughts on decoloniality in FPE research.
Drivers of migration intentions in coastal Vietnam under increased flood risk from sea level rise
Authors: Duijndam Sem J. , Botzen W. J. Wouter , Hagedoorn Liselotte C. , Bubeck Philip , Haer Toon , Pham My , Aerts Jeroen C. J. H. 
Published: January 2023

AbstractElevated flood risk due to sea level rise is expected to increase migration from coastal areas. This presents an enormous policy challenge given the hundreds of millions of people living in low-lying coastal areas globally. Despite its relevance, little empirical research has been done on what drives coastal residents to migrate or stay under increased flood risk. This study aims to improve the knowledge base on this topic by collecting and analyzing unique survey data of flood-prone coastal residents in Central Vietnam. To explain permanent migration intentions under increased flood risk, we present respondents with realistic scenarios of more frequent severe flooding and utilize a theoretical framework that incorporates flood risk indicators as well as key indicators of sustainable livelihoods. Results indicate that flood risk could play a major role in future migration behavior; permanent migration intentions strongly increase under the scenarios of increased flood risk. Several individual characteristics also play an important role in the migration decision. Regression analyses reveal that respondents who implemented in situ flood adaptation, and thereby reduced their flood risk, are less inclined to migrate. Past experiences during flooding such as evacuation or the reception of help from community members or the government are also strong predictors of migration intentions. Of the sustainable livelihood indicators, social capital plays the most important role, where a larger social network inside (outside) the place of residence is negatively (positively) related to migration intentions. We draw lessons from these insights for policymakers aiming to anticipate the challenge of sea level rise-induced migration.