bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect and Cerebral Blood Flow Mechanism of Exercise on Executive Function among Young Adults: A Double-blinded Randomised Controlled Trial Study
Authors: Liu Jianxiu , Min Leizi , Zhang Xiaoyu , Wu Meiting , Liu Ruidong , Ma Xindong 
Published: February 2023

Abstract
Objective: Studies have demonstrated that exercise benefits executive function. However, it is still unclear which exercise mode is optimal for protecting executive function among young adults and the evidence of the cerebral blood flow (CBF) mechanism of exercise on cognition. Thus, this study aimed to compare the intervention effect and the CBF mechanism of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on executive function.
Study design: This was a double-blinded randomised controlled trial study conducted from October 2020 to January 2021 (ClinicalTrials.gov identifier: NCT04830059). Ninety-three healthy young adults were randomized into the HIIT (N=33), MICT (N=32), and control groups (N=28). Participants in exercise groups were guided to perform 40 minutes of HIIT and MICT three times a week for 12 weeks, and the control group received health education for the same period. Executive function was measured by trail-making test (TMT), and CBF was measured by transcranial Doppler flow analyzer (EMS-9WA) before and after interventions.
Results: The time of the TMT task among the MICT group improved significantly compared with the control group (β = -10.175, 95% CI = -20.320, -0.031). The PI (β = 0.120, 95% CI = 0.018, 0.222), RI (β = 0.043, 95% CI = 0.005, 0.082), and S/D (β = 0.277, 95% CI = 0.048, 0.507) of the CBF among MICT group improved significantly compared with the control group. The time of TMT was associated with the Vs (F = 5.414, P = 0.022), PI (F = 4.973, P = 0.012), and RI (F = 5.845, P = 0.006). Moreover, the accuracy of TMT was associated with PI (F = 4.797, P = 0.036), RI (F = 5.394, P = 0.024), and S/D (F = 4.312, P = 0.05).
Conclusion: A 12-week MICT intervention improved CBF and executive function better than HIIT among young adults. Furthermore, CBF was one of the potential mechanisms that exercise improved the cognitive function of young people, which provided practical evidence for encouraging people to exercise regularly to maintain executive function and enhance brain health.
Identification immune-related biomarkers of ankylosing spondylitis based on bioinformatics analysis
Authors: Li Dongxu , Cao Ruichao , Dong Wei , Cheng Minghuang , Pan Xiaohan , Hu Zhenming , Hao Jie 
Published: February 2023

Abstract
Objective: The aim of this study is to search for key genes in ankylosing spondylitis through comprehensive bioinformatics analysis, thus providing some theoretical support for future diagnosis and treatment of AS and further research.
Methods: The expression matrix of ankylosing spondylitis was downloaded and integrated through public libraries. A bioinformatic approach was used to screen differential genes and perform functional enrichment analysis to obtain biological functions and signaling pathways associated with the disease. Weighted correlation network analysis (WGCNA) was used to further obtain key genes. Immune infiltration analysis was performed using the CIBERSORT algorithm to obtain the correlation analysis of key genes with immune cells. The GWAS data of AS were analyzed to identify the pathogenic regions of key genes in AS. Finally, potential therapeutic agents for AS were predicted using these key genes.
Results: A total of 7 potential biomarkers were identified: DYSF, BASP1, PYGL, SPI1, C5AR1, ANPEP and SORL1.ROC curves showed good prediction of each gene. T cell, CD4 naive, and neutrophil levels were significantly higher in the disease group compared to the paired normal group, and key gene expression was strongly correlated with immune cells.CMap results showed that the expression profiles of ibuprofen, forskolin, bongkrek-acid, and cimaterol showed the most significant negative correlation with the expression profiles of disease perturbations, suggesting that these drugs may play a role in AS play a good role in the treatment.
Conclusion: The potential biomarkers of AS screened in this study are closely related to the level of immune cell infiltration and play an important role in the immune microenvironment. This may provide help for clinical diagnosis and treatment of AS and provide new ideas for further research.
Malnutrition prevalence in cancer patients in Belgium: The ONCOCARE study
Authors: Rasschaert M. , Vandecandelaere P. , Marechal S. , D'hondt R. , Vulsteke C. , Mailleux M. , De Roock W. , Erps J. Van , Himpe U. , Man M. , Mertens G. , Ysebaert D. 
Published: February 2023

Abstract
RATIONALE

Unintentional weight loss and malnutrition are common among cancer patients. Malnutrition has been associated with impaired health-related quality of life, less well-tolerated chemotherapy regimens and shorter life duration. In Belgium there is a lack of epidemiological data on malnutrition in oncology patients at advanced stages of the disease.

METHODS

Malnutrition assessment data was collected through a prospective, observational study in 328 patients who started a neoadjuvant anticancer therapy regimen or who started 1st, 2nd or 3rd line anticancer therapy for a metastatic cancer via 3 visits according to regular clinical practice (baseline visit (BV) maximum 4 weeks before start therapy, 1st Follow up visit (FUV1) +/- 6 weeks after start therapy, FUV2 +/- 4 months after start therapy).

RESULTS

Prevalence of malnutrition risk at BV was high: 54.5% of the patients had a NRS ≥ 3 (NRS 2002) and increased during the study period (FUV1: 73.2%, FUV2: 70.1%). Prevalence of malnutrition based on physician subjective assessment (PSA) remained stable over the study period but was much lower compared to NRS results (14.0% − 16.5%). At BV, only 10% of the patients got a nutrition plan and 43.9% received ≤ 70% of nutritional needs, percentage increased during FU period (FUV1: 68.4%, FUV2: 67.6%). Prevalence of sarcopenia and cachexia were respectively 12.4% and 38.1% at BV and without significant variation during the study period. Figures were also higher compared to PSA. There were modifications in cancer treatment at FUV1 (25.2%) and at FUV2 (50.8%). The main reasons for these modifications at FUV1 were adverse events and tolerability. Patient reported daily questionnaires of food intake showed early nutritional deficits, preceding clinical signs of malnutrition, and therefore can be very useful in the ambulatory setting.

CONCLUSIONS

Prevalence of malnutrition and cachexia was high in advanced cancer patients and underestimated by physician assessment. Earlier and rigorous detection of nutritional deficit and adjusted nutritional intake could lead to improved clinical outcomes in cancer patients. Reporting of daily caloric intake by patients was also very helpful with regards to nutritional assessment.
Effect of fat replacement with HPMC and lecithin stabilised nanoemulsion on the physical characteristics and sensory attributes of short dough biscuits
Authors: Rodriguez-Garcia Julia , Kampa Jansuda , Signorello Antonio , Bull Stephanie , Frazier Richard 
Published: February 2023

Abstract

Biscuits contain high proportion of saturated fats, which could lead to an adverse health effect. The objective of this study was to study the functionality of complex nanoemulsion (CNE), which stabilised with hydroxypropyl methylcellulose and lecithin when used as a saturated fat replacer in short dough biscuits. Four biscuits formulations were studied including a control (butter), three formulations where 33% of the butter was replaced with extra virgin olive oil (EVOO), with CNE, and with the individual ingredient of the nanoemulsion added separately (INE). The texture properties, microstructure, and quantitative descriptive analysis with a trained sensory panel of the biscuits were evaluated. The results showed that CNE and INE gave place to doughs and biscuits with significantly higher (p < 0.05) hardness and fracture strength values than the control. The doughs made of CNE and INE showed significantly less oil migration during the storage than EVOO formulations, which confirmed by the confocal images. The trained panel did not find significant differences in crumb density and hardness on the first bite among CNE, INE and the control. In conclusion, nanoemulsion stabilised with HPMC and lecithin can work as a saturated fat replacer in short dough biscuits, providing satisfactory physical characteristics and sensory attributes.
Parameterization of a bioenergetic model to estimate shell, somatic and reproductive tissue growth of Ostrea edulis
Authors: Bertolini Camilla , Pastres Roberto 
Published: February 2023

Abstract
Several projects to reintroduce the native oyster Ostrea edulis are being carried out in Europe, some based on the restorative aquaculture approach. These projects could benefit from the application of a model which could predict oyster growth under different environmental conditions. Growth can be an indicator of suitable conditions and predicting it can particularly relevant for site selection. The simulated physiological processes underlying growth (e.g. clearance and respiration rates, storage of nutrients in tissues) could also support the estimation of the ecosystem functioning and services provided by new oyster reefs, thus allowing one to quantify the restoration benefits. Within this study, we developed a bioenergetic Individual Based Model (IBM) for Ostrea edulis, based on the Scope for Growth approach. Model parameters were estimated based on available literature data and a set of field data collected in the Venice Lagoon, which included time series of somatic and gonadal tissue and shell weight. The model was then successfully applied to the simulation of two further sets of previously published data. These findings suggest that the model could be used as a predictive tool for estimating Ostrea edulis growth over a wide range of environmental conditions and as a building block of oyster reef models.
Theoretical and numerical analysis of the Minimal Residual Method for solving the neutron transport equation in spherical geometry
Authors: Tizaoui Abdelkader 
Published: February 2023

Abstract
This paper focuses on an infinite dimensional adaptation of the Minimal Residual method for solving the neutron transport equation in spherical geometry. This method is based on a splitting of the collision operator strategy taking into account the characteristics of the transport operator. The theoretical and numerical analysis of this algorithm are given and compared to the methods given in [1, 2, 3].
Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis
Authors: Sun Feixiang , Tong Ying , Zhang Chuanpeng , Yang Susu , Liu Yitao , Ji Jie , Yu Ziyi , Zhao Yi 
Published: February 2023

Abstract
Microwave ablation (MWA) is increasingly used in clinical treatment and research of breast cancer, which has good therapeutic effect on primary and metastatic lesions. However, microwave ablation may lead to residual tumor cells due to incomplete ablation. The biological characteristics of residual tumor cells are unknown, and it is necessary to explore new adjuvant treatment methods to achieve better therapeutic effect. In this study, we demonstrated that the migration ability of residual breast cancer cells was enhanced after microwave ablation, but the proliferation ability was not significantly changed. Lawsone, an active ingredient in Chinese herbal medicine, significantly inhibited the proliferation and metastasis of residual breast cancer cells after microwave ablation in vivo and in vitro, and had synergistic effects with microwave ablation therapy. Mechanistic studies have shown that Lawsone exerts its anti-proliferation and anti-migration ability mainly by targeting NCAPG in residual breast cancer after microwave ablation. In addition, Lawsone-induced cellular inhibitory autophagy also plays a key role in its anticancer effect. In addition, NCAPG interacts with AURKB protein and jointly participates in the regulation of AKT/mTOR pathway to affect autophagy process. In short, these consequences demonstrate that Lawsone exerts its anti-proliferation and anti-metastasis effects on residual breast cancer cells after microwave ablation mainly by inhibiting NCAPG/AURKB/AKT/mTOR axis and inducing inhibitory autophagy, which provides more options for adjuvant therapy after microwave ablation.
Facilitating the access of the wider community into child and adolescent mental health services in Liverpool and Sefton (UK): The co-customisation of the CYP as One platform with young people; parents and health service providers
Authors: Santa Kristof , Dixon Chloe , Ganga Rafaela Neiva , Trainor Gemma , Smith Grahame , Furfie Victoria , Brown Holly 
Published: February 2023

Abstract
Background

Children and young people (CYP) from underrepresented communities in the Liverpool and Sefton regions (UK) experienced an increase in mental health needs, pre-pandemic. The “CYP as One” online platform was introduced via a co-creation schedule, to support the uptake of service users into child and adolescent mental health services. However, post-pandemic, the risk of poor mental health for CYP further increased. The current study co-customised the “CYP as One” platform to facilitate the wider access and inclusion of CYP from underserved communities into relevant mental health services through ensuring their viewpoints are sufficiently represented in the referral process.

Methods

The co-customisation schedule utilised the Living lab approach. Service user feedback was extracted from the “CYP as One” platform and data was generated via seven online focus groups conducted over two months. The focus groups included 16-19-year-old young people; parents of under 16-year-old children and health service providers. Content analysis was conducted on service user feedback, which was covertly presented to focus group participants to aid the conversations during the focus groups. The final data analysis involved conducting a thematic analysis on service user feedback and focus group data.

Findings

The thematic analysis on service user feedback and focus group data returned seven themes. Contrasting preferences of referral methods; the importance of inclusive access to a wide range of platform users; the relevance of demonstrating empathy and sympathy via non-face-to-face referrals; perspective taking aids in the mutual understanding of the needs of stakeholders involved; digital content should account for age and social-development related differences in this context; CYP and parents require timely and relevant mental health information; digital means of referral methods may integrate fragmented services.

Conclusions

Involving insights from service users; the public and health service providers allowed the in-depth exploration of everyday challenges service users may face when using the “CYP as One” platform. The solutions identified by participants to such issues represent a reliable improvement to the platform. Ensuring that the digital content can replace in-person referral processes is of utmost importance to support CYP who previously experienced difficulties in engaging with mental health services.
Bi-decadal Changes in Pre-monsoon Precipitation over Northwest Himalayas and its Large-scale Teleconnections
Authors: Aggarwal Deepanshu , Chakraborty Rohit , Attada Raju 
Published: February 2023

Abstract
During pre-monsoon season, the Northwest Himalayas region receives significantly larger seasonal proportion of precipitation than the pan Indian average which makes it vulnerable to ramifications of extreme precipitation. Hence, this study investigates the precipitation variations during pre-monsoon over the Northwest Himalayas for the period 1979–2018. It has been observed that, since 1998, the mean baseline for precipitation has shifted downwards, indicating a bi-decadal transition. Notably, since 1998, the seasonal average precipitation has fallen to 50% of pre-1998 levels with the month of March being the dominant contributor towards this overall decline. Consequent analysis revealed that the western disturbances (WDs) are primarily responsible for precipitation in this area during this season as the local atmospheric conditions are not conducive for any other source of moisture and precipitation. However, the strength of zonal moisture transport and WDs aided vorticities are seen to be weakening post 1998 which also interestingly coincides with the strongest El Nino phase on record and the start of a negative PDO cycle. As a result, the role of global teleconnections is investigated, which concluded that negative PDO conditions after 1998 have changed the atmospheric circulation pattern, causing air subsidence (stronger stability) over the study region and weakening the lower-level convergence and the westerly component of moisture transport; and this leads to the observed decline in pre-monsoon precipitation in the recent decades. Following that, the hypothesis was further verified using a threefold process involving a study of the change in circulation patterns, cause-effect cluster analysis and finally by case study comparisons.
Towards Creating the National Terminology Resources: The Case of Mongolian Terminology
Authors: Namsrai Munkhtsetseg 
Published: February 2023

Abstract
The goal of terminology work is to record and organize the meaning and usage of specialized terms and to make those available in various terminological resources like (online) termbases, specialized dictionaries, glossaries, and terminology standards, to use them in texts, translation, and specialized discourse. The present paper mainly focuses on analyzing the content of the recently launched online terminology dictionary in terms of terminology standards and aiming to seek further enhancement of it to consolidate terminology resources by creating a national term bank. Thus, the paper tries to evaluate the terminology resources in the dictionary “The Online Dictionary of Scientific Key Terms” in terms of quality assurance. As a result of the study, I have found some issues such as incorrect, incomplete, improper, inconsistent, and doublet entries occurring in the dictionary. Thus, the paper has highlighted the need to continue evaluating the terminology resources in the dictionary in terms of quality assurance. Additionally, the paper emphasized the importance of the concept-based approach and consistent modeling of terminographic components, namely the hierarchy of domain labels, as they are term identification markers instead of a flat list of domains.
In vitro Susceptibility of Nontuberculous Mycobacteria in China
Authors: Tan Yaoju , Ren Weicong , Ma Zichun , Shang Yuanyuan , Li Shanshan , Zhang Xuxia , Wang Wei , Yao Cong , Yuan Jinfeng , Li Liang , Pang Yu 
Published: February 2023

Abstract
Background: Precise species or subspecies identification of NTM clinical isolates is important for managing patients with NTM diseases. It is of great necessity to measure the prevalence of resistance to antimicrobial agents, and explore the risk factors associated with drug resistance by using NTM isolates from China.
Methods: A total of 355 NTM isolates were included in our analysis. Broth dilution method was used to determine in vitro drug susceptibility of NTM isolates.
Results: Clarithromycin (CLA) was the most potent drug for Mycobacterium intracellulare (MI). The resistance rate to CLA was 21%, yielding a minimum inhibitory concentrations (MIC)50 and MIC90 of 8 and 64 mg/L, respectively. 51% of MI isolates exhibited resistance to amikacin (AMK). For MABC, 6 and 49 isolates were categorized as resistant to CLA at Day 3 and 14, respectively. The resistance rate to CLA for Mycobacterium abscessus subspecies abscessus (MAA) was dramatically higher than that for Mycobacterium abscessus subspecies massiliense (MAM). Additionally, the percentage of patients presenting fever in the CLA-susceptible group was significantly higher than that in the CLA-resistant group.
Conclusions: Our data demonstrate that approximate one fifth of MI isolates are resistant to CLA. MAA is more resistant to CLA than MAM. The clinical manifestations of MI-infected patients caused by CLA-resistant bacilli seem to be milder than in CLA-susceptible group.
Genomic diversity analysis of IncHI3 plasmids and their derivatives sharing the IncHI3 core backbone
Authors: Mu Xiaofei , Wang Lingling , Yin Zhe , Jing Ying , Guan Jiayao , Chen Fangzhou , Li Xinyue , Zhang Zhi , Zhao Yuee , Hu Lingfei , Zhou Dongsheng , Wang Peng , Dai Erhei 
Published: February 2023

Abstract
Objectives
To dissect genomic features of IncHI3 plasmids and their derivatives sharing the IncHI3 core backbone.
Methods
An extensive genomic comparison was applied to all 20 available sequenced IncHI3 plasmids and their derivatives, including eight sequenced here and another 12 from GenBank.
Results
There were 20 IncHI3 plasmids and their derivatives, including 11 IncHI3 plasmids that contained single-replicon (repHI3B), double-replicons (repHI3B + repBIncFIB−6.1), and triple-replicons (repHI3B + repBIncFIB−6.1+repBIncFIB−8.1) and nine IncHI3 plasmid derivatives that were composed of the same IncHI3 backbone (including tra1 and tra2, and parABC) but different replication gene profiles instead of repHI3B. Based on the replication gene profiles, IncFIB-6.1, IncFIB-8.1, and IncFIB-6.1:8.1 plasmids were newly designated from derivatives. The 20 IncHI3 plasmids and their derivatives displayed massive gene acquisition and loss across the genomes and multiple accessory modules, including 13 Tn1696 derivatives, five MDR regions, two iuc regions, and 11 other key accessory regions. Two novel AGEs: In1765 and Tn7066, were first reported in this study.
Conclusions
Data presented here provides the evolution history of IncHI3 plasmids and their derivatives and a deeper insight into genomic diversification.
Rapid tropicalization evidence of subtidal seaweed assemblages along a coastal transitional zone
Authors: de Azevedo Jonas , Franco João N. , Vale Cândida G. , Lemos Marco , Arenas Francisco 
Published: February 2023

Abstract
Anthropogenic climate change, particularly seawater warming, is expected to drive quick shifts in marine species distribution transforming coastal communities. These shifts in distribution will be particularly noticeable in biogeographical transition zones. The continental Portuguese coast stretches from north to south along 900 Km. Despite this short spatial scale, the strong physical gradient intensified by the Iberian upwelling creates a transition zone where seaweed species from boreal and Lusitanian-Mediterranean origin coexist. On the northern coast, kelp marine forests thrive in the cold, nutrient-rich oceanic waters. In the south, communities resemble Mediterranean-type seaweed assemblages and are dominated by turfs. Recent evidence suggests that in these coastal areas, marine intertidal species are shifting their distribution edges as a result of rising seawater temperatures. Taking advantage of previous abundance data collected in 2012 from subtidal seaweed communities, a new sampling program was carried out in the same regions in 2018 to assess recent changes. The results confirmed the latitudinal gradient in macroalgal assemblages. More importantly we found significant structural and functional changes in a short period of six years, with regional increases of abundance of warm-affinity species, small seaweeds like turfs. Species richness, diversity, and biomass increase, all accompanied by an increase of community temperature index (CTI). Our findings suggest that subtidal seaweed communities in this transitional area have undergone major changes within a few years. Evidence of “fast tropicalization” of the subtidal communities of the Portuguese coast are strong indication of the effects of anthropic climate change over coastal assemblages.