bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ameliorative Effect of Ethanolic Extract of Curcuma longa (Tumeric) on Hematology profile of N-nitrosodiethylamine Administration in Wistar Rats
Authors: Onifade Olayinka , Akinloye Oluseyi Adeboye , Dosumu Oluwatosin A. , Shotuyo Aderemi , Amoo Olufemi Samuel 
Published: March 2023

Abstract
This present study compares the effect of ethanolic extract of Curcuma longa (EECL) and curcumin compound on the hematological profile of NDEA male and female Wistar rats. One hundred and twenty rats were randomly divided into twelve groups (n=5) for the experimental duration of 8 weeks. Group A,B,C,D,E and F received 100 mg/kg of NDEA each with 200 mg/kg, 400 mg/kg, 600 mg/kg EECL, 200 mg/kg curcumin compound and 100 mg/kg of syilbon (standard drug) respectively. Group G received 200 mg/kg of curcumin compound only, H received 200 mg/kg DMSO only, group I,J and K received 200 mg/kg, 400 mg/kg and 600 mg/kg of EECL while group L received only water. Animals were sacrificed at the end of 28 days of treatment. Blood samples were collected into labeled EDTA bottles for hematology analysis. There was significant decrease (P<0.05) in the white blood count (WBC), Mid-range absolute count (MID), granulocytes and platelet of the NDEA treated groups as compared with the control group in female leucogram as compared with male leucogram. The result of the erythrogram showed significant decrease (P>0.05) in red blood count (RBC) and hemoglobin (HGB), while Mean corpuscular hemoglobin concentration(MCHC),Mean corpuscular volume (MCV) and MCH concentration (MCHC) was significant increase (P<0.05) in NDEA group as compared with control in both male and female groups. the the findings suggests mitigative effect of ethanolic extract of Curcuma longa and pure curcumin compound on hematological dysfunctions in both male and female rats.
Global Trends and Frontiers of Age-Related Macular Degeneration From 2002 to 2021: A bibliometric analysis
Authors: Liu Yanli , Liu Huijuan , Lu Ping , Dong Yi 
Published: March 2023

Abstract
Introduction: Age-related macular degeneration (AMD) is a leading cause of visual impairment and severe vision loss, with the number of cases expected to increase because of the aging population. However, many aspects of AMD, including how it works and how it is treated, have yet to be elucidated. This study aims to identify and evaluate the global trends in AMD research over the last twenty years and visualize the frontiers using bibliometric analysis.
Methods: We collected all the publications on AMD from 2002 to 2021, analyzed trends within them, and defined the contributions of various countries/regions, institutions, core authors, and journals. Additionally, we used VOSviewer and CiteSpace software to combine networks and define the hot keywords in this field. AMD citation network was visualized using CitNetExplorer.
Results: In total, 16,145 publications on myopia were retrieved from 2001 to 2021. The United States has contributed the most publications (6,081) and the most citations (307,164). Holz FG contributed to the most publications, and Klein R had the most citations. Ophthalmology was the journal with the highest number of citations, and Investigative Ophthalmology & Visual Science had the maximum number of publications. The top 10 cited papers mainly focused on the therapeutic target. Keywords analysis and Citation network analysis were clustered into four groups: mechanisms, treatment, feature and classification, and prevalence, among which “mechanisms” was the largest cluster.
Conclusions: With the increasing prevalence of AMD, mechanisms for AMD control are a potential research hotspot and pressing public health issue. These results helped clarify the comprehensive research progress that has been made as well as the future trends in the study of AMD, which can assist and guide future research.
Predicting myopic changes in children wearing glasses using the Plusoptix photoscreener
Authors: Guimarães Sandra , Vieira Maria , Boas José Vilas 
Published: March 2023

Abstract
Introduction: With high increase in myopia prevalence, we aimed to assess if Plusoptix_A09 can be used in myopic children over spectacles to predicted visual acuity (VA) and myopic refraction changes.
Methods: Myopic children underwent a complete ophthalmological examination. Plusoptix_A09 was performed over spectacles. VA changes, refraction changes and time since previous glasses prescription, were determined. Age, current or past history of amblyopia, presence of strabismus and self-perception of VA changes were registered.
Results: 199 patients were included. Spherical power (SP) and spherical equivalent (SE) measured by Plusoptix_A09 over spectacles predicted both VA changes (p<.001) and refraction changes (p<.001). Values of SP<-0.06D or SE<-0.22D indicated a VA decrease (AUC>0.9, p<0.01) for sensitivity and specificity of 85.1%, 82.1% and 82.6%, 83.3%, respectively. Age and ophthalmological comorbidities did not influence Plusoptix_A09 measurements (p>0.05). Plusoptix_A09 over spectacles was a stronger predictor of VA changes when compared to children's self-perception, either in 4-9-year-old patients (p<.001 versus p=.628) and in 10-18-year-old children (OR<=0.066 versus OR=0.190). A decrease in SP and SE of -0.10D in Plusoptix_A09 predicted a myopia progression of -0.04D and -0.05D, respectively.
Conclusion/Relevance: This study unveiled new features for the Plusoptix, a worldwide available photoscreener used in amblyopia screening. When Plusoptix is performed in children with their glasses on, it can rapidly predict myopia progression. For each decrease of -0.10D in Plusoptix, a myopia progression of -0.05D, is expected. Moreover, Plusoptix is more reliable than children's self-perception of visual acuity changes, making it a useful tool either in primary care or ophthalmology practice.
Transarterial chemoembolization combined with lenvatinib, programmed death-1 inhibitor, and iodine-125 seed brachytherapy for hepatocellular carcinoma with portal vein tumor thrombosis
Authors: Lin Long-Wang , Yan Le-Ye , Ke Kun , Yang Wei-Zhu , Lin Jun-Qing , Huang Ning 
Published: March 2023

Abstract
Background: Therapy for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) is still controversial. This study was performed to evaluate the efficacy and safety of combination therapy comprising transarterial chemoembolization (TACE), lenvatinib, programmed death-1 inhibitor, and iodine-125 seed brachytherapy relative to TACE in combination with lenvatinib plus programmed death-1 inhibitor therapy and TACE plus lenvatinib therapy.
Methods: The data of HCC patients with PVTT from July 2017 to August 2022 were assessed in this single-center retrospective study. Primary study outcomes were progression-free survival (PFS) and overall survival (OS), while the secondary outcomes were disease control rate (DCR) and objective response rate (ORR), and treatment-related adverse events.
Results: We enrolled 150 patients finally, including 50 patients treated with TACE plus lenvatinib therapy (TACE+L group), 45 patients treated with TACE in combination with lenvatinib plus programmed death-1 inhibitor therapy (TACE+L+P group), and 55 patients treated with the combination therapy of transarterial chemoembolization along with iodine-125 seed brachytherapy, lenvatinib, and programmed death-1 inhibitor therapy (TACE+L+P+I125 group). The median OS in the TACE+L+P+I125 group (21.0; 95% confidence interval [CI]: 18.4~23.5 months) was significantly higher compared to the TACE+L group (10; 95% CI: 7.8~12.1months) (P = 0.006), while it was insignificantly higher compared to the TACE+L+P group (14.0; 95% CI: 10.7~17.2months) (P = 0.058). The median PFS in the TACE+L+P+I125 group (13.0; 95% CI: 10.2~15.7 months) was significantly higher compared to the TACE+L group (5.0; 95% CI: 4.2~5.7 months) (P = 0.014) and the TACE+L+P group (9.0; 95% CI: 6.7~11.2 months) (P = 0.048). Significant between-group differences in DCR (P = 0.015) were found. There were no significant between-group differences in treatment-related adverse events (P > 0.05).
Conclusions: A combination therapy of TACE, lenvatinib, programmed death-1 inhibitor, and iodine-125 seed brachytherapy significantly improve OS, PFS, and DCR and show better survival prognosis for HCC patients accompanied by PVTT.
Contraception Decision-making Autonomy among Adolescent Girls and Young Women in Uganda: Implications for Self Care-oriented Family Planning
Authors: Matovu Joseph KB , Amongin Dinah , Akulume Martha , Tuhebwe Doreen , Muringi Irene , Wanyenze Rhoda K. 
Published: March 2023

Abstract

Background: Reproductive autonomy is a key ingredient in driving the agenda for increased access to and utilization of self care-oriented family planning (FP) methods. We assessed current contraceptive use, contraception decision-making processes and interest in self care-oriented contraception among adolescent girls and young women (AGYW) in Uganda.
Methods: This secondary analysis used cross-sectional data from 2109 sexually-active AGYW aged 10-24 years obtained from a national survey conducted in September 2020. AGYW were asked if they had ever used or were currently using any FP method. Current contraceptive users were asked about who made the decision to use contraception in general and the specific FP methods that they were currently using in particular (i.e. respondent, partner, respondent and partner, or provider); those who made the decision to use contraception on their own were considered to have had contraception decision-making autonomy. We used a modified multivariable Poisson regression model to assess the adjusted prevalence ratio (adj. PR) and 95% confidence interval (95%CI) associated with contraception decision-making autonomy. Interest in self care-oriented FP methods was assessed descriptively.
Results: More than halfof AGYW (54.8%, n=1155) were current contraceptive users. Of these, 64.5% (n=745) made the decision to use contraception jointly with partner; 26.8% (n=310) made the decision on their own, while 8.7% (n=100) had the decision made by the partner. Fifty-nine per cent (n=684) made the final decision on the specific FP method to use jointly with partner; 27.8% (n=321) made the decision on their own while 12.9% (n=150) had the decision made by the respondent and partner or by the provider or partner. Having contraception discussion with partner prior to contraceptive use (adj. PR = 0.39; 95%CI: 0.32, 0.48) and being currently married (adj. PR=0.74; 95%CI: 0.56, 0.98) were negatively associated with contraceptive decision-making autonomy. Fifty-eight per cent of AGYW (n=1213) reported interest in obtaining information on how to access and/or use self care-oriented FP methods.
Conclusion: Slightly more than a quarter of current contraceptive users had contraception decision-making autonomy. Given the high interest in self care-oriented FP methods, AGYW should be empowered to make contraceptive decisions on their own.
Assessment of genetic diversity in wheat genotypes for sensitivity to heat stress during germination stage
Authors: Majeed Yasir , Fiaz Shaista , Zhu Xi , Ghaffar Sardar Muhammad Abdul , Awan Shahid Iqbal 
Published: March 2023

Abstract
Wheat production is seriously predisposed by extreme hot weather, which has fascinated increasing attention. It is important to compare wheat responses to heat at seedling stages, to explore the potential relationship between the performances at different growing stages and the possibility of early selection to accelerate heat tolerance breeding. In this experiment, twenty wheat genotypes were used including two local landraces. The seed of wheat genotypes were sown on filter paper in petri dishes and allowed to germinate at different temperatures of 25°C, 30°C, 35°C and 40°C. The experiment was replicated thrice under complete randomized design (CRD) with 2 factors. Analysis of variance (ANOVA) for bio-chemical and seedling traits showed that the genotypes differed highly significant for coleoptile length, shoot length, root length, fresh shoot weight, vigor index, glycine betaine and proline content. Effect of treatments on genotypes was highly significantly different for vigor index. Principal component analysis (PCA) revealed that four factors contributed 82.8% to total variability with the Eigen value greater than 0.7 at 35°C. From correlation analysis it was concluded that coleoptile length and germination percentage had positively highly correlated with shoot length, vigor index and shoot fresh weight. On the basis overall performance among the twenty wheat genotypes, it was concluded that Maraj, Fareed, Darabi, Zincol-16, Barsat, NARC-2011 and genotype Mundar performed well under all temperature regimes. Varieties NARC-2011, Inqalab-91 and Galexy also performed well in the case of H2O2 and antioxidant activity. These genotypes can be used under extreme hot temperature and in future breeding programs as they had a significant level of variability.
Quanto-chemical insight into the singlet-triplet energy gap of diazine-based TADF blue emitters for OLED devices
Authors: ZAITRI Lamia KARA , MEKELLECHE Sidi Mohamed 
Published: March 2023

Abstract
A series of molecules (1a-d, 2a-d, 3a-c) with donor-linker-acceptor-linker-donor (D-p-A-p-D) architecture type, having the dimethylacridine (DMA) as a strong electron-donor, a diazine as electron-accepting core and the phenyl as the π-linker, were theoretically studied as potential thermally activated delayed fluorescence (TADF) emitters in organic light-emitting diodes (OLEDs). The effect of the electron-accepting core (pyridazine, pyrimidine or pyrazine) with various linking positions of the phenyl bridge, on the energy gap between the lowest excited singlet and triplet states (ΔEST) of the modeled molecules is investigated using DFT and TD-DFT methods and the level B3LYP/6-31G(d,p) was selected to calculate their photophysical and optoelectronic properties. The present study revealed that i) the all designed molecules have strong exciton binding energies, ii) they emit light in the range 480-540 nm in toluene solvent from a charge transfer state, iii) they exhibit TADF properties because of their small energy gaps (ΔEST<0.3eV). Additionally, the obtained results also indicate that the singlet-triplet energy gap can be effectively fine-tuned by the simple modification of the linking position of the DMA units via the phenyl bridge. Moreover, the NPA analysis shows that the more electron-deficient diazine core induces smaller HOMO-LUMO overlap and smaller DEST energy gap. Finally, the molecules 1c, 2b, 2c and 3b, where the two phenyl bridges are linked at 4,5-, 4,6-, 2,3- and 2,5-positions, respectively of the pyrimidine core, with the lowest ΔEST values should be the more suitable for efficient reverse intersystem crossing (rISC) in the TADF molecules.
Gasless transaxillary endoscopic surgery for thyroid hemiagenesis with papillary thyroid carcinoma: a case report
Authors: Meng Kexin , Chen Xiaoliang , Shen Wei , Zheng Chuanming , Tan Zhou , Liang Juyong , Xin Ying 
Published: March 2023

Abstract
Background
Thyroid hemiagenesis (THA) is a rare abnormality featured by the absence of one thyroid lobe, and there have been no reports of using endoscopic thyroidectomy to treat papillary thyroid carcinoma with THA.
Case presentation
A case of THA with a missing right lobe was reported. Ultrasonography revealed a Thyroid Imaging, Reporting and Data System (TI-RADS) 5 lesion on the thyroid. The patient underwent a gasless transaxillary endoscopic thyroidectomy (GTET) during which it was discovered that the thyroid gland was located on the opposite side and that there were anatomic malformations present. While GTET contributes to clear vision during surgery and excellent postsurgical appearance, lateral forces produced by the retractor may dislocate tissues, obscuring the targeted thyroid, thus increasing the operative difficulties.
Conclusions
Transaxillary endoscopic surgical strategy is not overall superior to conventional approach and should be chosen consciously.
Application of Green Synthesized Silver Nanoparticles Against the Synthetic Azo Dye (Methyl Red) Degradation From Wastewater
Authors: Pandiyan Rajesh , Rajagopal Revathi , Subbiah Suresh Kumar 
Published: March 2023

Abstract

Nanotechnology is widely used by researchers due to its high surface volume ratio. It is nowadays employed in wastewater treatment due to its high efficiency. Metallic nanoparticles are used as it shows anti-microbial property and catalytic property. In the present study silver nanoparticle is used for treating the polluted water. Its characterisation is done using UV-Visible spectroscopy, FTIR (Fourier Transform Infrared Spectroscopy). The confirmation for the formation of the nanoparticle is done using the UV-Visible spectroscopy and functional group confirmation is done using the FTIR. In FTIR the peaks are observed at 3311.481 cm− 1 and 2402.918 cm− 1 corresponding to O-H Stretching and N-H Stretching. The peak at 1765.336 cm− 1 and 1358.396 cm− 1 represents the C-H Bending, and O-H Bending for the synthesised silver nanoparticle. This treated water can be further used for agricultural and domestic purposes.
E3 ligase casitas B-lineage lymphoma-b modulates peripheral T-cell tolerance via PI3K signaling in patients with immune thrombocytopenia
Authors: Liu Lu , Xiang Yujiao , Shao Linlin , Yuan Chenglu , Song Xiaofeng , Liu Yanfeng , Zhang Xianlei , Hou Ming , Peng Jun , Shi Yan 
Published: March 2023

Abstract
Background: The E3 ubiquitin ligase casitas B-lineage lymphoma-b (CBLB) is a newly identified component of the ubiquitin-dependent protein degradation system and is thought to be an important negative regulator of immune cells. CBLB is essential for establishing a threshold for T cell activation and for regulating peripheral T cell tolerance through various mechanisms. However, the role of CBLB in the pathogenesis of immune thrombocytopenia (ITP) remains unknown.
Methods: We performed quantitative proteomics to showed reduced CBLB expression and increased PI3K expression in CD4+ T cells from ITP patients. The regulating effect of CBLB on anergy induction was evaluated after transfecting with adenoviridae. We detected DNA methylation levels of the CBLB gene promoter and 5′UTR in CD4+ T cells using MassARRAY EpiTYPER.
Results: We found that CD4+ T cells from patients with ITP showed resistance to anergy. Furthermore, highly activated PI3K-AKT signaling, and decreased CBLB expression were found in these pathogenic T cells, indicating that they may be involved in anergy resistance in ITP. Further research revealed that CBLB overexpression effectively decreased p-AKT and reversed anergy resistance. Notably, 5′ untranslated regions (UTR) hypermethylation of CBLB was found in CD4+ T cells from patients with ITP, and low-dose decitabine significantly increased the expression of CBLB in patients with ITP in remission.
Conclusions: These results indicate that 5′UTR hypermethylation of the CBLB gene is involved in T cell anergy resistance in ITP through inhibition of CBLB expression. Upregulation of CBLB expression might be a potential therapeutic approach for ITP.
Malignant peritoneal mesothelioma presented with bilateral hydronephrosis and renal insufficiency: a case report
Authors: Luo JiSheng , Pan Jinhong , Zhong ChuanHua , Wang LiNa , Zhang GuoQing , Zhang Heng 
Published: March 2023

Abstract
Malignant peritoneal mesothelioma (MPM) is an extremely rare tumor with nonspecific clinical manifestations, challenging to diagnose. Herein, we reported a case of MPM with occult onset presenting with bilateral hydronephrosis and renal insufficiency. A 30-year-old man was admitted to the urology department with recurrent bilateral low back pain. The etiology was unclear after a series of laboratory tests, imaging examinations, bone marrow aspiration, renal puncture biopsy, ascites examination, ureteroscopy, and so on. Finally, MPM was diagnosed by laparoscopic exploration and biopsy. Moreover, during the course of the disease, the patient's bilateral ureters were compressed, and the obstruction could not be relieved after the placement of ordinary ureteral stents. Percutaneous nephrostomy (PCN) or metal ureteral stenosis was appropriate in managing malignant ureteral obstruction as it could improve renal function. The onset of this case was insidious, and the diagnosis was difficult, with a poor prognosis. To date, only a handful of cases have been reported. We hope this case can provide some enlightenment for our clinical work.
Differential binding of Clemizole among TRPC homologs
Authors: Uzma SAQIB , Demaree Isaac S , BAIG Mirza S , Obukhov Alexander G , Hajela Krishnan 
Published: March 2023

Abstract
The Transient Receptor Potential Canonical (TRPC) channels play important physiological roles and are involved in various signalling events in many organs. Amongst TRPC channels, the TRPC6 channel is one of the most studied, due to its involvement in multiple mechanisms of disease progression. Although several inhibitors of TRPC channels have been discovered, none of them have progressed to clinical trials. Clemizole is a potent TRPC5 antagonist with low affinity to TRPC6. In this study, we investigated the structural determinants and molecular aspects of TRPC5 and TRPC6 interaction with clemizole. We identified the critical clemizole binding site molecular determinants as well as the residues’ Accessible Surface Area (ASA) and Relative Accessible Surface Area (RASA) values. These results may facilitate drug discovery process.
Ictericia colestásica secundaria a biliopatía hipertensiva portal, a propósito de un caso con cavernomatosis portal
Authors: Navarro Beleno Kevin , Mosquera-Klinger Gabriel 
Published: March 2023

La biliopatía hipertensiva portal comprende las anomalías anatómicas y funcionales del tracto biliar intra y extrahepático, el conducto cístico y la vesícula biliar en pacientes con hipertensión portal. El compromiso de la vía biliar suele presentarse en obstrucción portal debido a transformación cavernomatosa de la porta.
Presentamos un caso de un paciente joven, con historia reciente de hipertensión portal y cavernomatosis de la porta, que presentó episodio de hepatitis colestásica y en estudios se le documentó una imagen de apariencia nodular con compresión extrínseca de la vía biliar distal compatible con tumor-like cavernoma. En este caso, se realizó un tratamiento endoscópico efectivo mediante colangiografía retrograda endoscópica (CPRE), esfinterotomía y stent biliar.
Efektifitas Alokasi Dana Desa di Kenagarian Sungai Rimbang Kabupaten Lima Puluh Kota
Authors: Cahyuli Indah Gita 
Published: March 2023

This study aims to investigate the effectiveness of village fund utilization in Kenagarian Sungai Rimbang, Suliki District, Lima Puluh Kota Regency, and to identify potential areas for development as well as obstacles faced during the utilization of the village funds. The research method utilized was qualitative with a descriptive approach, and data validation was conducted using member check and source triangulation techniques. Data analysis was carried out through data reduction, presentation, and conclusion drawing. The findings of this study suggest that the utilization of village funds has not been maximized for village development, as the focus has been primarily on infrastructure development. The potential of this Nagari lies in rice farming and agriculture, and the funds should be allocated towards community empowerment. Several obstacles were identified in the process of utilizing the village funds, including the low skills of human resources in Nagari, an insufficient amount of village funds to cover development in all Jorong, and low support from the village community.