bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPACT OF BORTEZOMIB-CONTAINING CHEMOTHERAPY REGIMEN ON MYOCARDIAL BIOELECTRICAL ACTIVITY IN PATIENTS WITH MULTIPLE MYELOMA AND CONCOMITANT CORONARY ARTERY DISEASE
Authors: Ostrovskyi V.L. 
Published: May 2023

Introduction. The mortality rate in oncology has been steadily decreasing since the 1990s, leading to increased life expectancy among cancer survivors. However, chemotherapy-related toxicity, including cardiotoxicity, remains a concern in the selection of chemotherapy drugs. Multiple myeloma, a type of cancer, has increased in prevalence and morbidity rates in recent decades. The specific treatments for multiple myeloma can have cardiotoxic effects, such as arterial hypertension, heart failure, acute coronary syndrome, and heart rhythm and conductivity disorders.
Objective. This study aims at investigating the unique characteristics of myocardial bioelectric activity in patients with progressive multiple myeloma and concomitant coronary artery disease undergoing bortezomib-containing chemotherapy.
Materials and Methods. A total of 42 multiple myeloma patients were examined, 22 (52.5%) of them were diagnosed to have concomitant coronary artery disease. Patients were divided into two groups based on the presence of coronary artery disease. All patients received bortezomib-containing chemotherapy regimens. Assessments were conducted in three time periods: before the chemotherapy, in 84 days, and in 140 days. General and biochemical blood counts were analyzed, and heart rhythm and conductivity disorders were assessed using 12-lead electrocardiography.
Results: The risk of developing anaemia did not significantly differ between the two groups during the first examination. A trend of increased conductivity disorder rates was observed in multiple myeloma patients with concomitant coronary artery disease compared to those without heart disorders. After the fourth chemotherapy course, there was a tendency for increased heart rhythm disorder rates in multiple myeloma patients with concomitant coronary artery disease compared to the previous examination, although supraventricular rhythm disorders were more frequently observed during the third examination.
Conclusions. Multiple myeloma onset was associated with similar rates of rhythm disorder development in patients with and without concomitant coronary artery disease, but combined rhythm disorders were observed only in patients with concomitant coronary artery disease. There has been found a tendency for increased heart rhythm disorder rates after the fourth chemotherapy course in multiple myeloma patients with concomitant coronary artery disease. Additionally, there has been a trend of increased conductivity disorder rates in multiple myeloma patients at high cardiovascular risk compared to those without concomitant heart disorders
BACTERIAL TRANSMISSION AND ANTIBIOTIC SENSITIVITY OF CAUSATIVE AGENTS IN PURULENT-SEPTIC COMPLICATIONS IN PATIENTS WITH A SEVERE COURSE OF ACUTE PANCREATITIS
Authors: Cherkun O. Yu. 
Published: May 2023

Introduction: Acute pancreatitis has emerged as a leading urgent abdominal condition, with a high mortality rate of up to 70% in cases of purulent-septic complications. The identification of specific causative agents during the infection stage of acute severe pancreatitis is challenging due to the various mechanisms by which pathogens can infiltrate parapancreatic fluid collections. However, early antibiotic prophylaxis is essential in the management of this patient population, considering the potential need for prolonged treatment involving multiple antibiotic rotations. This study aims at analyzing the changes in the microbial species spectrum responsible for purulent-septic complications in acute severe pancreatitis during the course of treatment.
Methods: We investigated 174 bacterial cultures obtained from patients diagnosed with acute severe pancreatitis who were treated at the Surgical Department of M.V. Sklifosovsky Poltava Regional Hospital between 2015 and 2018. Among these cultures, 87 were obtained during the initial surgical intervention (39 after initial ultrasound-guided drainage and 38 during the initial open surgical intervention), and 87 were obtained during the course of treatment.
Results: Among patients who underwent primary drainage of parapancreatic fluid collections, no aerobic flora was detected in 71.4% of cases, but subsequent bacterial cultures revealed microbial growth in 77.6% of patients. In patients who underwent open surgical intervention, pathological flora was detected in nearly all cases, both during the primary bacterial passage and in subsequent cultures. The species spectrum differed significantly between the primary and repeated bacterial passages. The initial cultures showed a predominance of gram-positive flora (S. epidermidis, Streptococcus spp., Enterococcus spp.), while repeated cultures demonstrated a notable increase in hospital-acquired strains and gram-negative flora (E. coli, Proteus spp., Acinetobacter spp.), along with a nearly three-fold increase in S. aureus. These findings have significant implications for selecting appropriate antibacterial agents throughout the treatment course. Notably, a substantial decrease in the sensitivity of multidrug-resistant strains to reserve antibiotics such as meropenem and trigecycline, by approximately 20%, was observed in subsequent bacterial studies.
Conclusion: The microbial spectrum and antibiotic sensitivity of pathogens causing purulent-septic complications in acute severe pancreatitis undergo dynamic changes during the course of treatment. These findings underscore the importance of conducting repeated bacterial cultures and adjusting antibiotic therapy accordingly to optimize treatment outcomes.
A new on-line self-adapting fuzzy controller design using unidimensional input-output with dynamical membership functions
Authors: Saidi Sief Ali 
Published: May 2023

Here, we develop a fuzzy controller using a new online self-adapting design. The objective of this work is to control a nonlinear process by using a one-dimensional input rule variable, instead of error and error variation. The initial limits of the fuzzy logic membership functions are mostly depend on experiments and previous knowledge of the dynamic process behaviors. Generally, the membership function parameters have a significant impact on control signal amplitude and, consequently on the convergence and stability of the controller-plant system. The proposed technique determines the limits of the antecedent membership functions online using the kth and k - 1th outputs of the controlled plant and reference model, respectively. Meanwhile, the limits of the consequent membership functions are calculated using error and error variation. This approach ensures: (i) that the input/output variables have the required fuzzy space, (ii) the controlled plant follows the desired reference model, and (iii) the control signal amplitude is within acceptable limits. Additionally, (iiii) it takes into account the dynamic variability of the process and the existence of an overshoot. The membership function parameters are updated continuously through a self-adapting procedure, ensuring improved control performance. Ultimately, the proposed approach is improved using two nonlinear systems.
Poisson image restoration via an adaptive Euler’s elastica regularization
Authors: Ma Mingxi , Yang Junci 
Published: May 2023

Many recent studies have shown that Euler’s elastica regularization performs better than the famous total variation (TV) regularization on keeping image features in smooth regions during the process of denoising. In addition, an adaptive weighted matrix combined with total variation is a key technique for well restoring local features of image. Considering these two factors, in this paper, we propose an adaptive Euler’s elastica model for Poisson image restoration so as to well preserve both image features in smooth regions and local features of image. To solve this non-smooth and non-convex model efficiently, we design an alternating direction method of multipliers. Experiments on both natural and synthetic images illustrate the effectiveness and efficiency of the proposed method over the state-of-the-art methods in Poisson restoration and denoising, respectively. In particular, for Poisson restoration, our proposed method improves the TV method up to 2.46 about PSNR for dealing with the Peppers image with Gaussian blur and noise level σ = 1. In addition, the proposed method for Poisson denoising gets higher PSNR and SSIM values than the TAC method, while costing less CPU time.
Experimental evaluation of fracture properties of aluminum alloy 1050-H14 by small punch test
Authors: Doan The Yen , Pham Hang Thi , Le Khai Quang , Nguyen Thi-Hang-Nga , Van Nghiem Vinh 
Published: May 2023

Although ductile fracture properties of aluminum alloy have been examined by several research works, the effect of strain rate in small punch test is still unclear. An investigation on rate sensitivity of fracture mechanical characteristics of aluminum alloy in small punch test is necessary. In the present study, an experimental investigation of small punch test is performed at different deformation rate in quasi-static test for aluminum alloy 1050-H14. The strain-rate sensitivity of fracture properties are discussed based on the force-deflection curve as well as observation of fracture surface of deformed specimen after testing. The obtained results show that the material possesses a positive rate-sensitivity in the investigated range of displacement rate from 0.48 to 1.26 mm/min. The necking appears in a small region due to inhomogeneous deformation in the direction of cross-section at lower deformation rate. In the case of higher rate of deformation, more uniform deformation in the direction of cross-section and the local ductile fracture with more dimples can be observed.
Circuits, Currents, Kirchhoff, and Maxwell
Authors: Eisenberg Robert 
Published: May 2023

Electricity flows in circuits that bring us power and information. The current flow in circuits is defined by the Maxwell equations that are as exact and universal as any in science. The Maxwell-Ampere law defines the source of the magnetic field as a current. In a vacuum, like that between stars, there are no charges to carry that current. In a vacuum, the source of the magnetic field is the displacement current, \(\varepsilon_0\ \partial\mathbf{E}/\partial t\). Inside matter, the source of the magnetic field is the flux of charge added to the displacement current. This total current obeys a version of Kirchhoff’s current law that is implied by the mathematics of the Maxwell equations, and therefore is as universal and exact as they are. Kirchhoff's laws provide a useful coarse graining of the Maxwell equations that avoids calculating the Coulombic interactions of \({10}^{23}\) charges yet provide sufficient information to design the integrated circuits of our computers. Kirchhoff's laws are exact, as well as coarse grained because they are a mathematical consequence of the Maxwell equations, without assumption or further physical content. In a series circuit, the coupling in Kirchhoff’s law makes the total current exactly equal everywhere at any time. The Maxwell equations provide just the forces needed to move atomic charges so the total currents in Kirchhoff’s law are equal for any mechanism of charge movement. Those movements couple processes for any physical mechanism of charge movement. In biology, Kirchhoff coupling is an important part of membrane transport and enzyme function. For example, it helps the membrane enzymes cytochrome c oxidase and ATP-synthase produce ATP, the biological store of chemical energy.
The Effect of Sorbitol on the Mechanical Properties of Temu Ireng Rhizomes (Curcuma Aeruginosa Roxb.) Starch Biodegradable Plastic
Authors: Manurung Santy Meilisa , Frida Erna , Susilawati Susilawati , Humaidi Syahrul , Sinuhaji Perdinand 
Published: May 2023

Biodegradable plastic is made by mixing from temu ireng rhizomes starch matrix, sorbitol as a plasticizer, and chitosan as a filler through the melt intercalation method. heating process at 800C and drying at 70oC. The results show that the addition of chitosan and sorbitol has an effect on the characteristics of the plastic. The best tensile strength results on biodegradable plastic with a mass composition of starch: chitosan 5:5 gram without the addition of sorbitol is 4.03 MPa. The best percentage of elongation in plastic with a composition of starch: chitosan 8:2 gr and 3 ml Sorbitol is 99.68%. The best water resistance to biodegradable plastic was the composition of starch: chitosan 5:5 gr without the addition of sorbitol is 83.33%. And the best biodegradability in plastic with a composition of 5:5 chitosan without the addition of sorbitol was 100% for 9 days. FTIR test results show that biodegradable plastic have the same wavelength as their constituent raw materials. This shows that the resulting film only interacts physically.
Показники та критерії оцінювання ефективності функціонування системи управління оборонними ресурсами сектору безпеки та оборони України (структура, зміст)
Authors: Semenenko Oleh , Skurinevska Lesia 
Published: May 2023

Мета роботи: визначення структури та змісту показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами сектору безпеки та оборони України.
Метод дослідження: методи аналізу та синтезу, методи воєнно-економічної теорії, індукції та дедукції, а також порівняння, формалізація, абстрагування та моделювання.
Результати дослідження: визначено структуру і зміст показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами, а також сформовано вимоги до них та запропоновано підхід до їх класифікації.
Теоретична цінність дослідження: розкриття основних аспектів формування системи показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами, а також визначено можливі напрями та шляхи подальшого її розвитку.
Тип статті: теоретичний, описовий, практичний, методичний.
Engineering Escherichia coli for diagnosis and management of hyperuricemia
Authors: Gencer Gozde , Mancuso Christopher , Chua Koon Jiew , Ling Hua , Costello Cait M. , Chang Matthew Wook , March John C. 
Published: May 2023

Uric acid disequilibrium is implicated in chronic hyperuricemia-related diseases. Long-term monitoring and lowering of serum uric acid levels may be crucial for diagnosis and effective management of these conditions. However, current strategies are not sufficient for accurate diagnosis and successful long-term management of hyperuricemia. Moreover, drug-based therapeutics can cause side effects in patients. The intestinal tract plays an important role in maintaining healthy serum acid levels. Hence, we investigated the engineered human commensal Escherichia coli as a novel method for diagnosis and long-term management of hyperuricemia. To monitor changes in uric acid concentration in the intestinal lumen, we developed a bioreporter using the uric acid responsive synthetic promoter, pucpro, and uric acid binding Bacillus subtilis PucR protein. Results demonstrated that the bioreporter module in commensal E. coli can detect changes in uric acid concentration in a dose-dependent manner. To eliminate the excess uric acid, we designed a uric acid degradation module, which overexpresses an E. coli uric acid transporter and a B. subtilis urate oxidase. Strains engineered with this module degraded all the uric acid (250 µM) found in the environment within 24 h, which is significantly lower (p &lt; 0.001) compared to wild type E. coli. Finally, we designed an in vitro model using human intestinal cell line, Caco-2, which provided a versatile tool to study the uric acid transport and degradation in an environment mimicking the human intestinal tract. Results showed that engineered commensal E. coli reduced (p &lt; 0.01) the apical uric acid concentration by 40.35% compared to wild type E. coli. This study shows that reprogramming E. coli holds promise as a valid alternative synthetic biology therapy to monitor and maintain healthy serum uric acid levels.
Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer
Authors: Zheng Yanfen , Li Zhiguo , Liu Chuyi , Fan Xiaotong , Luo Zheng , Li Zibiao , Wu Yun-Long 
Published: May 2023

Introduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery.Methods: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The catalytic activity, ROS scavenge and oxygen supply ability of GCN was validated. The therapeutic effect of GCN was verified in the diabetic gingival ulcer model.Results: The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis.Discussion: This multifunctional GCN with ROS depletion, continuous oxygen supply and good biocompatibility, which might provide a novel therapeutic strategy for effective treatment of diabetic oral mucosa ulcers.
Faster smooth muscle cell coverage in ultrathin-strut drug-eluting stent leads to earlier re-endothelialization
Authors: Hahn Dongwoo , Lee Donghoon , Hyun Woonggyu , Cho Yunnie , Yoon Chang-Hwan , Jeon Ki-Hyun , Kang Si-Hyuck , Youn Tae-Jin , Chae In-Ho 
Published: May 2023

Background: The ultrathin-strut drug-eluting stent (DES) has shown better clinical results than thin- or thick-strut DES. We investigated if re-endothelialization was different among three types of DES: ultrathin-strut abluminal polymer-coated sirolimus-eluting stent (SES), thin-strut circumferential polymer-coated everolimus-eluting stent (EES), and thick-strut polymer-free biolimus-eluting stent (BES) to gain insight into the effect of stent design on promoting vascular healing.Methods: After implanting three types of DES in the coronary arteries of minipigs, we performed optical coherence tomography (OCT) at weeks 2, 4, and 12 (n = 4, each). Afterward, we harvested the coronary arteries and performed immunofluorescence for endothelial cells (ECs), smooth muscle cells (SMCs), and nuclei. We obtained 3D stack images of the vessel wall and reconstructed the en face view of the inner lumen. We compared re-endothelialization and associated factors among the different types of stents at different time points.Results: SES showed significantly faster and denser re-endothelialization than EES and BES at weeks 2 and 12. Especially in week 2, SES elicited the fastest SMC coverage and greater neointimal cross-sectional area (CSA) compared to EES and BES. A strong correlation between re-endothelialization and SMC coverage was observed in week 2. However, the three stents did not show any difference at weeks 4 and 12 in SMC coverage and neointimal CSA. At weeks 2 and 4, SMC layer morphology showed a significant difference between stents. A sparse SMC layer was associated with denser re-endothelialization and was significantly higher in SES. Unlike the sparse SMC layer, the dense SMC layer did not promote re-endothelialization during the study period.Conclusion: Re-endothelialization after stent implantation was related to SMC coverage and SMC layer differentiation, which were faster in SES. Further investigation is needed to characterize the differences among the SMCs and explore methods for increasing the sparse SMC layer in order to improve stent design and enhance safety and efficacy.
Efficacy of adjuvant metronidazole therapy on peri-implantitis: a systematic review and meta-analysis of randomized clinical studies
Authors: López-Valverde Nansi , López-Valverde Antonio , Blanco-Rueda José Antonio 
Published: May 2023

Peri-implant diseases are pathological conditions that affect the survival of dental implants. Etiological studies are limited, accepting a prevalence of 20% at the implant level and 24% at the patient level. The benefits of adjuvant metronidazole are controversial. A systematic review and meta-analysis of RCTs according to PRISMA and PICOS was performed with an electronic search over the last 10 years in MEDLINE (PubMed), WOS, Embase, and Cochrane Library. The risk of bias was measured using the Cochrane Risk of Bias tool and the methodological quality using the Jadad scale. Meta-analysis was performed with RevMan version 5.4.1, based on mean difference and standard deviation, with 95% confidence intervals; the random-effects model was selected, and the threshold for statistical significance was defined as p &lt; 0.05. A total of 38 studies were collected and five were selected. Finally, one of the studies was eliminated because of unanalyzable results. All studies reached a high methodological quality. A total of 289 patients were studied with follow-up periods from 2 weeks to 1 year. Statistical significance was only found, with respect to the use of adjunctive metronidazole, in the pooled analysis of the studies (p = 0.02) and in the analysis of the radiographic values reported on peri-implant marginal bone levels, in the studies with a 3-month follow-up (p = 0.03). Discrepancies in the use of systemic metronidazole require long-term randomized clinical trials (RCTs) to determine the role of antibiotics in the treatment of peri-implantitis.