bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trustworthy Science Advice: The Case of Policy Recommendations
Authors: Gundersen Torbjørn 
Published: July 2023

AbstractThis paper examines how science advice can provide policy recommendations in a trustworthy manner. Despite their major political importance, expert recommendations are understudied in the philosophy of science and social epistemology. Matthew Bennett has recently developed a notion of what he calls recommendation trust, according to which well-placed trust in experts’ policy recommendations requires that recommendations are aligned with the interests of the trust-giver. While interest alignment might be central to some cases of public trust, this paper argues against the significance of interest-alignment to meritorious public trust. First, political bodies and citizens can have a basic kind of well-placed recommendation trust in science advice based on an all-things-considered judgement regarding the possession of relevant competencies, responsible conduct, and a proper institutional design. Moreover, scientists’ policy recommendations can be seen as open-ended and as dynamic proposals that enable inter-institutional reasoning and political deliberation. Finally, by providing conditional recommendations, scientists can expand the scope of feasible policy options from which political bodies can choose, thus making the condition of interest alignment even less significant to the trustworthy provision of recommendations.
Pitfalls in hydrologic model calibration in a data scarce environment with a strong seasonality: experience from the Adyar catchment, India
Authors: Tigabu Tibebe B. , Wagner Paul D. , Narasimhan Balaji , Fohrer Nicola 
Published: July 2023

AbstractProcess-based hydrologic models can provide necessary information for water resources management. However, the reliability of hydrological models depends on the availability of appropriate input data and proper model calibration. In this study, we demonstrate that common calibration procedures that assume stationarity of hydrological processes can lead to unsatisfactory model performance in areas that experience a strong seasonal climate. Moreover, we develop a more robust calibration procedure for the Soil and Water Assessment Tool (SWAT) in the Adyar catchment of Chennai, India. Calibration was carried out based on seasonal decomposition and by successively shifting the calibration period. Daily and monthly streamflow records were used to investigate how these different calibration procedures influence model parameterization. Results show that SWAT model performance improved when calibrated after separating the streamflow into wet and dry seasons. The wet season calibration increased the Kling Gupta Efficiency coefficient and Nash–Sutcliffe Efficiency coefficient values from 0.56 to 0.68 and 0.19 to 0.51, respectively, compared to calibration based on wet and dry seasons together. In addition, when calibration time periods were shifted, resultant sets of model parameter values and performance metrics differed. Calibration based on the 2004–2009 period resulted in an overestimation of streamflow by 8.2%, whereas the overestimation was 12.1%, 18.3%, and 20.0% for the 2004–2010, 2004–2011, and 2004–2012 periods, respectively. This study underlines that both the availability of observed streamflow data and the way these data are applied to calibration have a strong impact on model parameterization and performance.
Integrating Vision Transformer-Based Bilinear Pooling and Attention Network Fusion of RGB and Skeleton Features for Human Action Recognition
Authors: Sun Yaohui , Xu Weiyao , Yu Xiaoyi , Gao Ju , Xia Ting 
Published: July 2023

AbstractIn this paper, we propose VT-BPAN, a novel approach that combines the capabilities of Vision Transformer (VT), bilinear pooling, and attention network fusion for effective human action recognition (HAR). The proposed methodology significantly enhances the accuracy of activity recognition through the following advancements: (1) The introduction of an effective two-stream feature pooling and fusion mechanism that combines RGB frames and skeleton data to augment the spatial–temporal feature representation. (2) The development of a spatial lightweight vision transformer that mitigates computational costs. The evaluation of this framework encompasses three widely employed video action datasets, demonstrating that the proposed approach achieves performance on par with state-of-the-art methods.
Stick-slip squirmers: slip asymmetry can qualitatively change self-swimming characteristics of squirmers
Authors: Yang Fu-Ling , Chen You-An , Premlata A.R. , Wei Hsien-Hung 
Published: July 2023

A slip asymmetry can break the fore–aft symmetry of the local hydrodynamic force distribution on the surface of an otherwise no-slip or uniform-slip particle. Here, we use the Lorentz reciprocal theorem to demonstrate that such asymmetry, even in a fractional amount, can qualitatively alter the swimming characteristics of a self-propelled spherical squirmer, markedly different from those of no-slip or uniform-slip squirmers. Unlike the usual tangential squirming by the thrust-providing B1 mode and the type-determining B2 mode, we discover two unique features for a stick-slip squirmer. First, the squirmer can acquire a swimming velocity
U
without the B1 mode but simply by a symmetric extensile/contractile squirming from the B2 mode, which is able to reverse the swimming direction of the squirmer. Second, a stresslet

$\boldsymbol{\mathsf{S}}$

can also be induced by a unidirectional squirming from the B1 mode, capable of inverting the squirmer's stresslet from extensile type to contractile type or vice versa to change the squirmer from puller to pusher or in a reverse manner. We further show that the two squirming modes can reinforce or compete with each other to enhance or diminish
U
and

$\boldsymbol{\mathsf{S}}$

due to interplays between the asymmetric squirming forces on the stick and the slip faces. A phase diagram is also established to categorize a variety of newly emerging swimming states, such as an enhanced/degraded puller/pusher and a backward puller/pusher, depending on the relative strength of the squirming modes β = B2/B1, the direction of the stick-slip polarity and the degree of the slip disparity. As a result of such cooperative and competitive natures, a stick-slip squirmer can swim more or less efficiently than no-slip and uniform-slip ones. These distinctive features arising from stick-slip disparity can not only be made geometrically tuneable for steering the motion of a squirmer, but also provide new means for making efficient artificial microswimmers using amphiphilic Janus particles.
Geochronology and formal stratigraphy of the Sturtian Glaciation in the Adelaide Superbasin
Authors: Lloyd Jarred C. , Preiss Wolfgang V. , Collins Alan S. , Virgo Georgina M. , Blades Morgan L. , Gilbert Sarah E. , Subarkah Darwinaji , Krapf Carmen B.E. , Amos Kathryn J. 
Published: July 2023

AbstractThe glaciogenic nature of the Yudnamutana Subgroup was first recognized over a century ago, and its global significance was recognized shortly after, with the eventual postulation of a global Sturtian Glaciation and Snowball Earth theory. Much debate on the origin and timing of these rocks, locally and globally, has ensued in the years since. A significant corpus of research on the lithology, sedimentology, geochronology and formal lithostratigraphy of these sequences globally has attempted to resolve many of these debates. In the type area for the Sturtian Glaciation, South Australia’s Adelaide Superbasin, the lithostratigraphy and sedimentology are well understood; however, formal stratigraphic nomenclature has remained complicated and contested. Absolute dates on the stratigraphy are also extremely sparse in this area. The result of these longstanding issues has been disagreement as to whether the sedimentary rocks of the Yudnamutana Subgroup are truly correlative throughout South Australia, and if they were deposited in the same time span recently defined for Sturtian glacial rocks globally, c. 717 Ma to c. 660 Ma. This study presents a large detrital zircon study, summarizes and compiles existing global geochronology for the Sturtian Glaciation and revises the formal lithostratigraphic framework of the Yudnamutana Subgroup. We show equivalence of the rocks that comprise the revised Sturt Formation, the main glaciogenic unit of the Yudnamutana Subgroup, and that it was deposited within the time span globally defined for the Sturtian Glaciation.
Temporal and Spatial Evolution of Herbivorous Waterbird Habitat in Floodplain Wetland Driven by Hydrology
Authors: Teng Jiakun , Xia Shaoxia , Duan Houlang , Liu Yu , Yu Xiubo , Yang Wenjuan 
Published: July 2023

AbstractThe hydrological rhythm of floodplain wetlands affected by natural climate variability and human activities is the driving factor affecting the distribution of herbivorous geese habitats. It has always been challenging to determine its long‐term variation, due to the lack of data on species distribution and broad wetland observation. In this study, the key normalized difference vegetation index threshold range suitable for herbivorous geese, greater white‐fronted geese (Anser albifrons, GWG) and bean geese (Anser fabalis, BG), was discovered by combining GPS tracking data with Landsat satellite data. The suitable habitat area and distribution variation characteristics of GWG and BG from 1982 to 2020 were extracted based on the threshold range. The results showed that the suitable habitat area had a declining trend after 2003, that the distribution had moved toward the lake's center, and that its average elevation had decreased by around 1 m, particularly during the arrival period. The change of herbivorous geese habitat is caused by the continuous drying of Poyang Lake. The study can offer a rational scientific foundation for wetland waterbird protection and watershed hydrological management.
Comparing Sediment Microbial Communities of Arctic Beaver Ponds to Tundra Lakes and Streams
Authors: Shannon Kelly C. , Christman Natasha R. , Crump Byron C. , Carey Michael P. , Koch Joshua , Lapham Laura L. , O’Donnell Jonathan , Poulin Brett A. , Tape Ken D. , Clark Jason A. , Colwell Frederick S. 
Published: July 2023

AbstractIn recent decades the habitat of North American beaver (Castor canadensis) has expanded from boreal forests into Arctic tundra ecosystems. Beaver ponds in Arctic watersheds are known to alter stream biogeochemistry, which is likely coupled with changes in the activity and composition of microbial communities inhabiting beaver pond sediments. We investigated bacterial, archaeal, and fungal communities in beaver pond sediments along tundra streams in northwestern Alaska (AK), USA and compared them to those of tundra lakes and streams in north‐central Alaska that are unimpacted by beavers. β‐glucosidase activity assays indicated higher cellulose degradation potential in beaver ponds than in unimpacted streams and lakes within a watershed absent of beavers. Beta diversity analyses showed that dominant lineages of bacteria and archaea in beaver ponds differed from those in tundra lakes and streams, but dominant fungal lineages did not differ between these sample types. Beaver pond sediments displayed lower relative abundances of Crenarchaeota and Euryarchaeota archaea and of bacteria from typically anaerobic taxonomic groups, suggesting differences in rates of fermentative organic matter (OM) breakdown, syntrophy, and methane generation. Beaver ponds also displayed low relative abundances of Chytridiomycota (putative non‐symbiotic) fungi and high relative abundances of ectomycorrhizal (plant symbionts) Basidiomycota fungi, suggesting differences in the occurrence of plant and fungi mutualistic interactions. Beaver ponds also featured microbes with taxonomic identities typically associated with the cycling of nitrogen and sulfur compounds in higher relative abundances than tundra lakes and streams. These findings help clarify the microbiological implications of beavers expanding into high latitude regions.
Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica
Authors: Krais Annette M. , de Joode Berna van Wendel , Liljedahl Emelie Rietz , Blomberg Annelise J. , Rönnholm Anna , Bengtsson Marie , Cano Juan Camilo , Hoppin Jane A. , Littorin Margareta , Nielsen Christel , Lindh Christian H. 
Published: July 2023

Abstract
Background
4-hydroxychlorothalonil (HCT, R182281), a transformation product of the fungicide chlorothalonil, was recently identified in human serum and breast milk. There are indications that HCT may be more toxic and environmentally persistent than chlorothalonil.

Objective
Our aim was to investigate serum concentrations of HCT in pregnant women in Sweden and Costa Rica.

Methods
We developed a quantitative analytical method for HCT using liquid chromatography tandem mass spectrometry. We measured HCT in 1808 serum samples from pregnant women from the general population in Sweden (1997–2015) and in 632 samples from 393 pregnant women from an agricultural population in Costa Rica (2010–2011). In Swedish samples, we assessed time trends and investigated seasonality. In the Costa Rican samples, we evaluated variability between and within women and explanatory variables of HCT concentrations.

Results
HCT was detected in all serum samples, and the limit of detection was 0.1 µg/L. The median HCT concentration in the Swedish samples was 4.1 µg/L (interquartile range [IQR] of 2.9 − 5.8 µg/L), and 3.9 times higher in the Costa Rican samples (median: 16.1 µg/L; IQR: 10.6 − 25.0 µg/L). We found clear seasonal variation with higher concentrations in the first half of each year among Swedish women. In the Costa Rican study, women working in agriculture and living near banana plantations had higher HCT concentrations, whilst higher parity and having a partner working in agriculture were associated with decreased HCT, and no clear seasonal pattern was observed.

Impact statement
For the first time, this study quantifies human exposure to the fungicide chlorothalonil and/or its transformation product 4-hydroxychlorothalonil (HCT, R182281) and finds higher serum concentrations in women from a tropical agricultural setting as compared with women from the general population in Sweden.
Genetically engineered mouse models of head and neck cancers
Authors: Tasoulas Jason , Srivastava Sonal , Xu Xiaonan , Tarasova Valentina , Maniakas Anastasios , Karreth Florian A. , Amelio Antonio L. 
Published: July 2023

AbstractThe head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone. Remarkable progress has been made in understanding the underlying disease mechanisms, personalizing care based on each tumor’s individual molecular characteristics, and even therapeutically exploiting the inherent vulnerabilities of these neoplasms. In this regard, genetically engineered mouse models (GEMMs) have played an instrumental role. While progress in the development of GEMMs has been slower than in other major cancer types, several GEMMs are now available that recapitulate most of the heterogeneous characteristics of head and neck cancers such as the tumor microenvironment. Different approaches have been employed in GEMM development and implementation, though each can generally recapitulate only certain disease aspects. As a result, appropriate model selection is essential for addressing specific research questions. In this review, we present an overview of all currently available head and neck cancer GEMMs, encompassing models for head and neck squamous cell carcinoma, nasopharyngeal carcinoma, and salivary and thyroid gland carcinomas.
Imaging the electron charge density in monolayer MoS2 at the Ångstrom scale
Authors: Martis Joel , Susarla Sandhya , Rayabharam Archith , Su Cong , Paule Timothy , Pelz Philipp , Huff Cassandra , Xu Xintong , Li Hao-Kun , Jaikissoon Marc , Chen Victoria , Pop Eric , Saraswat Krishna , Zettl Alex , Aluru Narayana R. , Ramesh Ramamoorthy , Ercius Peter , Majumdar Arun 
Published: July 2023

AbstractFour-dimensional scanning transmission electron microscopy (4D-STEM) has recently gained widespread attention for its ability to image atomic electric fields with sub-Ångstrom spatial resolution. These electric field maps represent the integrated effect of the nucleus, core electrons and valence electrons, and separating their contributions is non-trivial. In this paper, we utilized simultaneously acquired 4D-STEM center of mass (CoM) images and annular dark field (ADF) images to determine the projected electron charge density in monolayer MoS2. We evaluate the contributions of both the core electrons and the valence electrons to the derived electron charge density; however, due to blurring by the probe shape, the valence electron contribution forms a nearly featureless background while most of the spatial modulation comes from the core electrons. Our findings highlight the importance of probe shape in interpreting charge densities derived from 4D-STEM and the need for smaller electron probes.
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies
Authors: de Almeida José Guilherme , Gudgin Emma , Besser Martin , Dunn William G. , Cooper Jonathan , Haferlach Torsten , Vassiliou George S. , Gerstung Moritz 
Published: July 2023

AbstractMany hematological diseases are characterized by altered abundance and morphology of blood cells and their progenitors. Myelodysplastic syndromes (MDS), for example, are a group of blood cancers characterised by cytopenias, dysplasia of hematopoietic cells and blast expansion. Examination of peripheral blood slides (PBS) in MDS often reveals changes such as abnormal granulocyte lobulation or granularity and altered red blood cell (RBC) morphology; however, some of these features are shared with conditions such as haematinic deficiency anemias. Definitive diagnosis of MDS requires expert cytomorphology analysis of bone marrow smears and complementary information such as blood counts, karyotype and molecular genetics testing. Here, we present Haemorasis, a computational method that detects and characterizes white blood cells (WBC) and RBC in PBS. Applied to over 300 individuals with different conditions (SF3B1-mutant andSF3B1-wildtype MDS, megaloblastic anemia, and iron deficiency anemia), Haemorasis detected over half a million WBC and millions of RBC and characterized their morphology. These large sets of cell morphologies can be used in diagnosis and disease subtyping, while identifying novel associations between computational morphotypes and disease. We find that hypolobulated neutrophils and large RBC are characteristic ofSF3B1-mutant MDS. Additionally, while prevalent in both iron deficiency and megaloblastic anemia, hyperlobulated neutrophils are larger in the latter. By integrating cytomorphological features using machine learning, Haemorasis was able to distinguish SF3B1-mutant MDS from other MDS using cytomorphology and blood counts alone, with high predictive performance. We validate our findings externally, showing that they generalize to other centers and scanners. Collectively, our work reveals the potential for the large-scale incorporation of automated cytomorphology into routine diagnostic workflows.
Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine
Authors: Meile Susanne , Du Jiemin , Staubli Samuel , Grossmann Sebastian , Koliwer-Brandl Hendrik , Piffaretti Pietro , Leitner Lorenz , Matter Cassandra I. , Baggenstos Jasmin , Hunold Laura , Milek Sonja , Guebeli Christian , Kozomara-Hocke Marko , Neumeier Vera , Botteon Angela , Klumpp Jochen , Marschall Jonas , McCallin Shawna , Zbinden Reinhard , Kessler Thomas M. , Loessner Martin J. , Dunne Matthew , Kilcher Samuel 
Published: July 2023

AbstractThe rapid detection and species-level differentiation of bacterial pathogens facilitates antibiotic stewardship and improves disease management. Here, we develop a rapid bacteriophage-based diagnostic assay to detect the most prevalent pathogens causing urinary tract infections: Escherichia coli, Enterococcus spp., and Klebsiella spp. For each uropathogen, two virulent phages were genetically engineered to express a nanoluciferase reporter gene upon host infection. Using 206 patient urine samples, reporter phage-induced bioluminescence was quantified to identify bacteriuria and the assay was benchmarked against conventional urinalysis. Overall, E. coli, Enterococcus spp., and Klebsiella spp. were each detected with high sensitivity (68%, 78%, 87%), specificity (99%, 99%, 99%), and accuracy (90%, 94%, 98%) at a resolution of ≥103 CFU/ml within 5 h. We further demonstrate how bioluminescence in urine can be used to predict phage antibacterial activity, demonstrating the future potential of reporter phages as companion diagnostics that guide patient-phage matching prior to therapeutic phage application.
Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1
Authors: Gao Yuchen , Chi Ying , Chen Yunfei , Wang Wentian , Li Huiyuan , Zheng Wenting , Zhu Ping , An Jinying , Duan Yanan , Sun Ting , Liu Xiaofan , Xue Feng , Liu Wei , Fu Rongfeng , Han Zhibo , Zhang Yingchi , Yang Renchi , Cheng Tao , Wei Jun , Zhang Lei , Zhang Xiaomin 
Published: July 2023

AbstractMesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying the immunosuppressive function of MSCs are not fully understood, hindering the development of standardized MSC-based therapies for clinical use. In this study, we profile the single-cell transcriptomes of MSCs isolated from adipose tissue (AD), bone marrow (BM), placental chorionic membrane (PM), and umbilical cord (UC). Our results demonstrate that MSCs undergo a progressive aging process and that the cellular senescence state influences their immunosuppressive activity by downregulating PD-L1 expression. Through integrated analysis of single-cell transcriptomic and proteomic data, we identify GATA2 as a regulator of MSC senescence and PD-L1 expression. Overall, our findings highlight the roles of cell aging and PD-L1 expression in modulating the immunosuppressive efficacy of MSCs and implicating perinatal MSC therapy for clinical applications in inflammatory disorders.