bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of different pretreatments on the adhesion of nanodiamond composite films on Ti substrates via coaxial arc plasma deposition
Authors: Osman Lama , Ali Ali M , Zkria Abdelrahman , Naragino Hiroshi , Yoshitake Tsuyoshi 
Published: May 2023

Abstract
In this study, we report on the novel growth of nanodiamond composite (NDC) films on titanium (Ti) substrates using the coaxial arc plasma deposition (CAPD) at room temperature, which offers several advantages over conventional growth techniques. CAPD employs a unique coaxial arc plasma gun structure that provides a supersaturated condition of highly energetic carbon ions (C+) for ultrafast quenching on the substrate, promoting the growth of nanodiamond grains. This allows for NDC films’ growth on diverse substrates without the need for initial seeding or substrate heating. However, the growth of NDC films on Ti substrates at room temperature is challenging due to the native oxide layer (TiO2). Here, we grew NDC films on Ti substrates using three different pretreatments: (i) hydrofluoric acid (HF) etching, (ii) insertion of a titanium carbide (TiC) intermediate layer, and (iii) in situ Ar+ plasma etching. The morphology and structure of the grown NDC films were examined by 3D laser, high-resolution scanning electron microscopies (HR-SEM), Raman, and x-ray photoelectron (XPS) spectroscopies. Our results demonstrate that in situ Ar+ plasma etching is the most effective pretreatment method for completely removing the native TiO2 layer compared to the other two ex situ pretreatments, in which re-oxidation is more likely to occur after these pretreatments. Furthermore, NDC films grown using the hybrid Ar+ ion etching gun (IG) and CAPD exhibit the highest sp
3 content (63%) and adhesion strength (16 N).
A Qualitative Examination of Tobacco Use and Smoking Cessation Among Gender Minority Adults
Authors: Sun Christina J , Doran Kye M , Sevelius Jae M , Bailey Steffani R 
Published: May 2023

Abstract

Background
Despite the elevated prevalence of smoking among gender minority adults, little is known about the factors that influence their tobacco use and cessation.

Purpose
We identified and examined factors that influence tobacco use and cessation for gender minority adults, using a conceptual framework based on the Model of Gender Affirmation and Gender Minority Stress Model.

Methods
Nineteen qualitative, semi-structured in-depth interviews were conducted with gender minority adults who smoke or no longer smoke and were recruited from the Portland, OR metropolitan area. Interviews were audio-recorded, professionally transcribed, and analyzed utilizing thematic analysis.

Results
Four main themes were generated. Gender minority adults smoke to cope with general and gender minority-specific stressors. Smoking was described as a social behavior that was influenced and sustained by community and interpersonal relationships. Smoking cessation was motivated by health concerns (both general and gender minority-specific) and moderated by conducive life circumstances. Recommendations for tobacco cessation interventions highlighted the importance and role of social support. Participants expressed a strong desire for gender minority-specific tobacco cessation programs. There are unique and complex factors that contribute to the higher prevalence of smoking observed among gender minority adults.

Conclusions
Tobacco cessation interventions are urgently needed for this population and should be tailored to address the unique factors that impact tobacco use and cessation among gender minority people to increase the likelihood of success.
Addressing barriers to increased adoption of DPYD genotyping at a large multisite cancer center
Authors: Morris Sarah A , Moore Donald C , Musselwhite Laura W , Lopes Karine Eboli , Hamilton Alicia , Steuerwald Nury , Hanson Sarah L , Larck Chris , Swift Kristen , Smith Mathew , Kadakia Kunal C , Chai Seungjean , Hwang Jimmy J , Patel Jai N 
Published: May 2023

Abstract

Purpose
To describe the implementation of an in-house genotyping program to detect genetic variants linked to impaired dihydropyrimidine dehydrogenase (DPD) metabolism at a large multisite cancer center, including barriers to implementation and mechanisms to overcome barriers to facilitate test adoption.

Summary
Fluoropyrimidines, including fluorouracil and capecitabine, are commonly used chemotherapy agents in the treatment of solid tumors, such as gastrointestinal cancers. DPD is encoded by the DPYD gene, and individuals classified as DPYD intermediate and poor metabolizers due to certain genetic variations in DPYD can experience reduced fluoropyrimidine clearance and an increased risk of fluoropyrimidine-related adverse events. Although pharmacogenomic guidelines provide evidence-based recommendations for DPYD genotype–guided dosing, testing has not been widely adopted in the United States for numerous reasons, including limited education/awareness of clinical utility, lack of testing recommendations by oncology professional organizations, testing cost, lack of accessibility to a comprehensive in-house test and service, and prolonged test turnaround time. Based on stakeholder feedback regarding barriers to testing, we developed an in-house DPYD test and workflow to facilitate testing in multiple clinic locations at Levine Cancer Institute. Across 2 gastrointestinal oncology clinics from March 2020 through June 2022, 137 patients were genotyped, and 13 (9.5%) of those patients were heterozygous for a variant and identified as DPYD intermediate metabolizers.

Conclusion
Implementation of DPYD genotyping at a multisite cancer center was feasible due to operationalization of workflows to overcome traditional barriers to testing and engagement from all stakeholders, including physicians, pharmacists, nurses, and laboratory personnel. Future directions to scale and sustain testing in all patients receiving a fluoropyrimidine across all Levine Cancer Institute locations include electronic medical record integration (eg, interruptive alerts), establishment of a billing infrastructure, and further refinement of workflows to improve the rate of pretreatment testing.
ProgCAE: a deep learning-based method that integrates multi-omics data to predict cancer subtypes
Authors: Liu Qingchun , Song Kai 
Published: May 2023

Abstract
Determining cancer subtypes and estimating patient prognosis are crucial for cancer research. The massive amount of multi-omics data generated by high-throughput sequencing technology is an important resource for cancer prognosis. Deep learning methods can integrate such data to accurately identify more cancer subtypes. We propose a prognostic model based on a convolutional autoencoder (ProgCAE) that can predict cancer subtypes associated with survival using multi-omics data. We demonstrated that ProgCAE predicted subtypes of 12 cancer types with significant survival differences and outperformed traditional statistical methods for predicting the survival of most patients with cancer. Supervised classifiers can be constructed based on subtypes predicted by robust ProgCAE.
An inhibitory mechanism for suppressing high salt intake inDrosophila
Authors: Dey Manali , Ganguly Anindya , Dahanukar Anupama 
Published: May 2023

AbstractHigh concentrations of dietary salt are harmful to health. Like most animals, Drosophila melanogaster are attracted to foods that have low concentrations of salt, but show strong taste avoidance of high salt foods. Salt in known on multiple classes of taste neurons, activating Gr64f sweet-sensing neurons that drive food acceptance and 2 others (Gr66a bitter and Ppk23 high salt) that drive food rejection. Here we find that NaCl elicits a bimodal dose-dependent response in Gr64f taste neurons, which show high activity with low salt and depressed activity with high salt. High salt also inhibits the sugar response of Gr64f neurons, and this action is independent of the neuron’s taste response to salt. Consistent with the electrophysiological analysis, feeding suppression in the presence of salt correlates with inhibition of Gr64f neuron activity, and remains if high salt taste neurons are genetically silenced. Other salts such as Na2SO4, KCl, MgSO4, CaCl2, and FeCl3 act on sugar response and feeding behavior in the same way. A comparison of the effects of various salts suggests that inhibition is dictated by the cationic moiety rather than the anionic component of the salt. Notably, high salt-dependent inhibition is not observed in Gr66a neurons—response to a canonical bitter tastant, denatonium, is not altered by high salt. Overall, this study characterizes a mechanism in appetitive Gr64f neurons that can deter ingestion of potentially harmful salts.
Life history and bionomics ofGlycobius speciosus(Coleoptera: Cerambycidae: Cerambycinae: Clytini)
Authors: Adams Kim B , Allen Douglas C , Stehman Stephen V 
Published: May 2023

AbstractGlycobius speciosus (Say) was studied in New York State to elucidate poorly known aspects of its biology. Head capsule size from excavated larvae coupled with gallery lengths measured at the time of excavation was used to characterize larval development. Partial life tables indicated nearly 20% of G. speciosus survive to adulthood. Larvae experienced 30% of their mortality during early development, 27% during mid-larval development, and 43% during late larval development. Predation by hairy woodpeckers, Dryobates villosus (Linnaeus) (Piciformes: Picidae), the only unambiguous source of mortality, accounted for 43% mortality in naturally infested trees located and followed 2004–2009, and 74% late instar mortality. One parasitoid, Dolichomitus irritator (Fabricius) (Hymenoptera: Ichneumonidae), was recovered from a single larva. Beetles emerged between 316 accumulated DD (base 10 °C) and 648 DD. Males emerged prior to, or simultaneously with, females and lived longer. Female fecundity averaged 41.3 ± 6 eggs. Larval eclosion occurred 7–10 days after oviposition. Non-functional ovipositors observed in 16% of females represented an appreciable reproductive loss. In 77% of infested trees 1 oviposition site was located and in 70% of oviposition sites examined only 1 or 2 larvae successfully eclosed, penetrated the bark to the phloem-xylem interface, and began feeding. Beetles preferred southern and eastern aspects for oviposition which occurred preferentially on the lower bole (&lt;20 cm). Male beetles had longer and wider antennae than females, pronotal pits containing gland pores, and a straight to concave posterior margin of the terminal sternite compared to the more rounded margin of females.
Ground beetles suppress slugs in corn and soybean under conservation agriculture
Authors: Mugala Thabu , Brichler Kirsten , Clark Bobby , Powell Gareth S , Taylor Sally , Crossley Michael S 
Published: May 2023

Abstract
Conservation agriculture practices such as eliminating tillage and planting high residue cover crops are becoming increasingly important in field crop systems in the US Mid-Atlantic. However, these practices have sometimes been associated with an increase in moderate to severe damage to field crops by slugs. Conserving natural enemy populations is a desirable way to manage slug infestations because remedial control measures are limited. Here, we tested the effects of conservation practices, weather, and natural enemies on slug activity-density measured by tile traps placed among 41 corn and soybean fields during the spring of 2018 and 2019 in the Northern Shenandoah Valley, Virginia, USA. We found that a positive effect of cover crops on slug activity-density was reduced by tillage and that slug activity-density declined with increasing ground beetle activity-density. Slug activity-density also declined with decreasing rainfall and increasing average temperature. Weather was the only significant predictor of ground beetle activity-density, which was reduced in sites and weeks that were relatively hot and dry or that were cool and wet. However, we also found a marginally significant negative effect of pre-plant insecticides on ground beetles. We suggest that the observed interacting effects of cover crops and tillage reflect favorable conditions for slugs provided by increased small grain crop residue that can be mitigated to some extent by even low levels of tillage. More broadly, our study suggests that implementation of practices known to promote recruitment of ground beetles in crop fields can improve natural suppression of slugs in corn and soybean that are being increasingly cultivated according to conservation agriculture practices.
Healthcare cost and survival in patients with non-functioning pituitary adenoma
Authors: Olsson Daniel S , Svensson Mikael , Labori Frida , De Geer Anna , Johannsson Gudmundur 
Published: May 2023

Abstract

Objective
Pituitary adenomas and their consequences impact mortality and morbidity. We studied the healthcare costs, survival, and cost-effectiveness of growth hormone (GH) vs no GH replacement in patients with non-functioning pituitary adenoma (NFPA).

Design and methods
A cohort study including all NFPA patients followed from 1987 or the date of diagnosis until the time of death or December 31, 2019, in the Västra Götaland region, Sweden. Data to assess resource use, costs, survival, and cost-effectiveness were collected from patient records and regional/national healthcare registries.

Results
A total of 426 patients with NFPA (274 men) with a follow-up of 13.6 ± 6.8 years (mean ± SD) were included. The total annual healthcare cost was higher in patients receiving GH (€9287) than those without GH (€6770), mainly driven by a higher pharmaceutical cost. Glucocorticoid replacement therapy (P = .02), diabetes insipidus (P = .04), body mass index (BMI) (P &lt; .01), and hypertension (P &lt; .01) were all individually associated with a higher total annual cost. The survival rate was higher in the GH group (HR [hazard ratio] 0.60; P = .01) and reduced in patients with glucocorticoid replacement (HR 2.02; P &lt; .01) or diabetes insipidus (HR 1.67; P = .04). The cost per gained life-year for GH vs no GH replacement was about €37 000.

Conclusions
This healthcare utilization study identified several factors driving the cost of care in NFPA patients, such as GH replacement, adrenal insufficiency, and diabetes insipidus. Life expectancy was increased in those with GH replacement and reduced in patients with adrenal insufficiency and diabetes insipidus.
Assessment of long-term adverse events regarding different COVID-19 vaccine regimens within an 18-month follow-up study
Authors: Sadat Larijani Mona , Sorouri Rahim , Eybpoosh Sana , Doroud Delaram , Moradi Ladan , Ahmadinezhad Mozhgan , Bavand Anahita , Ashrafian Fatemeh , Tajmehrabi Namini Parinaz , Zali Mahsan , Ramezani Amitis 
Published: May 2023

Abstract
Early reports on coronavirus disease 2019 (COVID-19) vaccines presented the short-term adverse events (AEs). This follow-up study investigated a standard regimen based on protein subunit vaccines, PastoCovac and PastoCovac Plus, and the combinational vaccine regimens including AstraZeneca/PastoCovac Plus and Sinopharm/PastoCovac Plus. The participants were followed up to 6 months post the booster shot. All the AEs were collected through in-depth interviews using a valid researcher-made questionnaire and were evaluated regarding the association with the vaccines. Of the 509 individuals, 6.2% of the combinational vaccine participants had late AEs, of whom 3.3% suffered from cutaneous manifestations, followed by 1.1% arthralgia complaints, 1.1% with neurologic disorders, 0.3% ocular problems and 0.3% metabolic complications, with no significant difference between the vaccine regimens. For the standard regimen, 2% of the individuals experienced late AEs as (1%), neurological disorders (0.3%), metabolic problems (0.3%) and involvement of joints (0.3%). Notably, 75% of the AEs were persistent up to the end of the study. A low number of late AEs were captured in 18 months as 12 improbable, 5 unclassifiable, 4 possible and 3 probable associated AEs with the vaccine regimens. The benefits of COVID-19 vaccination far exceed the potential risks and late AEs seem to be uncommon.
Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival
Authors: Milman Sofiya , Lerman Ben , Ayers Emmeline , Zhang Zhengdong , Sathyan Sanish , Levine Morgan , Ye Kenny , Gao Tina , Higgins-Chen Albert , Barzilai Nir , Verghese Joe 
Published: May 2023

Abstract
Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect against frailty. First, a reliable quantification of frailty resilience is needed. We developed a novel measure of frailty resilience, the Frailty Resilience Score (FRS), that integrates frailty genetic risk, age, and sex. Application of FRS to the LonGenity cohort (n = 467, mean age 74.4) demonstrated its validity compared to phenotypic frailty and its utility as a reliable predictor of overall survival. In a multivariable-adjusted analysis, 1-standard deviation increase in FRS predicted a 38% reduction in the hazard of mortality, independent of baseline frailty (p &lt; .001). Additionally, FRS was used to identify a proteomic profile of frailty resilience. FRS was shown to be a reliable measure of frailty resilience that can be applied to biological studies of resilience.
Pharmacy students’ opinion of the routine use of pharmaceutical pictograms on a health care train serving rural limited literacy patients
Authors: Dowse Ros 
Published: May 2023

Abstract

Objectives
To assess pharmacy student opinion of the routine use of pictograms for counselling and communicating medicine-related information.

Methods
A Google Forms survey was sent to co-ordinators at five Pharmacy Schools who distributed the link to 152 students following their 5-day work placement. The survey included Likert Scale and open questions on prior pictogram exposure, their usefulness in practice and their design.

Key findings
Opinion of pictogram usefulness in facilitating communication with patients was positive, with 104 (95.4%) rating their usefulness as good/excellent. Students noted language and low literacy as communication barriers which pictograms helped to mitigate. Only 24.8% (N = 27) reported that using pictograms required extra time during the dispensing process. Most students reported that patients liked the pictograms and found it easy to teach patients the pictogram meaning to clarify verbal and written medicine-related information. Pictograms were regarded by most students as simple, clear, culturally acceptable and able to communicate their core message clearly. A third agreed that they should have additional detail and be more realistic, some offered suggestions for modification. Many suggested expanding pictogram use to primary care clinics and hospitals.

Conclusions
This study presents unique finding relating to the role and value of pictograms in practice. Opinion of routine pictogram use was largely positive, particularly given significant language and literacy barriers in this rural population. The extra time taken using pictograms was generally not regarded as a barrier to their adoption. Pictogram quality and design were considered to be good, with expanded use of pictograms suggested.
Evaluating global Vaccinium germplasm for resistance against invasive Drosophila suzukii (Diptera: Drosophilidae)
Authors: Sampson Blair , Stringer Stephen , Hummer Kim , Babiker Ebrahiem , Werle Chris , Adamczyk John , Shaw Donna 
Published: May 2023

Abstract
Control of spotted-wing Drosophila, Drosophila suzukii, in small fruits emphasizes biological, cultural, and chemical approaches, whereas studies of host plant resistance as a form of genetic control are just getting underway. The identification of resistance patterns among genotypes of host plants whose fruit, leaves, roots, stems, or seeds are specifically targeted by an invasive pest is the first step in the development of an effective genetic control. Therefore, a detached fruit bioassay was developed to screen for D. suzukii oviposition and larval infestation within berries from 25 representative species and hybrids of wild and cultivated Vaccinium. Ten Vaccinium species showed strong resistance; among them, two wild diploids originating from within the fly’s native range: V. myrtoides and V. bracteatum. Other resistant species came from the sections Pyxothamnus and Conchophyllum. They included New World V. consanguineum and V. floribundum. Large-cluster blueberry, V. amoenum, and three Floridian genotypes of related rabbiteye blueberry, V. virgatum, were the only hexaploids expressing strong resistance against D. suzukii. Most screened blueberry genotypes from managed lowbush and cultivated highbush types were susceptible to the flies’ attacks (i.e., oviposition). Tetraploid blueberries tended to host the most eggs, whereas diploids and hexaploids harbored 50%–60% fewer eggs, on average. D. suzukii cannot lay eggs or complete development in the smallest, sweetest, and firmest diploid fruits. Likewise, certain genotypes of large-fruited tetraploid and hexaploid blueberry strongly curbed D. suzukii egg-laying and larval growth, indicating the possibility of heritable resistance operating against this invasive fly species.
Association of rurality, socioeconomic status, and race with pancreatic cancer surgical treatment and survival
Authors: Brooks Gabriel A , Tomaino Marisa R , Ramkumar Niveditta , Wang Qianfei , Kapadia Nirav S , O’Malley A James , Wong Sandra L , Loehrer Andrew P , Tosteson Anna N A 
Published: May 2023

Abstract

Background
Pancreatectomy is a necessary component of curative intent therapy for pancreatic cancer, and patients living in nonmetropolitan areas may face barriers to accessing timely surgical care. We evaluated the intersecting associations of rurality, socioeconomic status (SES), and race on treatment and outcomes of Medicare beneficiaries with pancreatic cancer.

Methods
We conducted a retrospective cohort study, using fee-for-service Medicare claims of beneficiaries with incident pancreatic cancer (2016-2018). We categorized beneficiary place of residence as metropolitan, micropolitan, or rural. Measures of SES were Medicare–Medicaid dual eligibility and the Area Deprivation Index. Primary study outcomes were receipt of pancreatectomy and 1-year mortality. Exposure-outcome associations were assessed with competing risks and logistic regression.

Results
We identified 45 915 beneficiaries with pancreatic cancer, including 78.4%, 10.9%, and 10.7% residing in metropolitan, micropolitan, and rural areas, respectively. In analyses adjusted for age, sex, comorbidity, and metastasis, residents of micropolitan and rural areas were less likely to undergo pancreatectomy (adjusted subdistribution hazard ratio = 0.88 for rural, 95% confidence interval [CI] = 0.81 to 0.95) and had higher 1-year mortality (adjusted odds ratio = 1.25 for rural, 95% CI = 1.17 to 1.33) compared with metropolitan residents. Adjustment for measures of SES attenuated the association of nonmetropolitan residence with mortality, and there was no statistically significant association of rurality with pancreatectomy after adjustment. Black beneficiaries had lower likelihood of pancreatectomy than White, non-Hispanic beneficiaries (subdistribution hazard ratio = 0.80, 95% CI = 0.72 to 0.89, adjusted for SES). One-year mortality in metropolitan areas was higher for Black beneficiaries (adjusted odds ratio = 1.15, 95% CI = 1.05 to 1.26).

Conclusions
Rurality, socioeconomic deprivation, and race have complex interrelationships and are associated with disparities in pancreatic cancer treatment and outcomes.