bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyaluronic Acid‐Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential
Authors: Kotla Niranjan G. , Mohd Isa Isma Liza , Larrañaga Aitor , Maddiboyina Balaji , Swamy Samantha K. , Sivaraman Gandhi , Vemula Praveen K. 
Published: March 2023

AbstractIn recent years, the development of hyaluronic acid or hyaluronan (HA) based scaffolds, medical devices, bioconjugate systems have expanded into a broad range of research and clinical applications. Research findings over the last two decades suggest that the abundance of HA in most mammalian tissues with distinctive biological roles and chemical simplicity for modifications have made it an attractive material with a rapidly growing global market. Besides its use as native forms, HA has received much interest on so‐called “HA‐bioconjugates” and “modified‐HA systems”. In this review, the importance of chemical modifications of HA, underlying rationale approaches, and various advancements of bioconjugate derivatives with their potential physicochemical, and pharmacological advantages are summarized. This review also highlights the current and emerging HA‐based conjugates of small molecules, macromolecules, crosslinked systems, and surface coating strategies with their biological implications, including their potentials and key challenges discussed in detail.
Recent Advances in Organ‐on‐Chips Integrated with Bioprinting Technologies for Drug Screening
Authors: Tabatabaei Rezaei Nima , Kumar Hitendra , Liu Hongqun , Lee Samuel S. , Park Simon S. , Kim Keekyoung 
Published: March 2023

AbstractCurrently, the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ‐on‐chips are newly emerged platforms for drug screening and disease metabolism investigation. These microfluidic devices attempt to recapitulate the physiological and biological properties of different organs and tissues using human‐derived cells. Recently, the synergistic combination of additive manufacturing and microfluidics has shown a promising impact on improving a wide array of biological models. In this review, different methods are classified using bioprinting to achieve the relevant biomimetic models in organ‐on‐chips, boosting the efficiency of these devices to produce more reliable data for drug investigations. In addition to the tissue models, the influence of additive manufacturing on microfluidic chip fabrication is discussed, and their biomedical applications are reviewed.
Polymeric Memristor Based Artificial Synapses with Ultra‐Wide Operating Temperature
Authors: Li Jiayu , Qian Yangzhou , Li Wen , Yu Songcheng , Ke Yunxin , Qian Haowen , Lin Yen‐Hung , Hou Cheng‐Hung , Shyue Jing‐Jong , Zhou Jia , Chen Ye , Xu Jiangping , Zhu Jintao , Yi Mingdong , Huang Wei 
Published: March 2023

AbstractNeuromorphic electronics, being inspired by how the brain works, hold great promise to the successful implementation of smart artificial systems. Among several neuromorphic hardware issues, a robust device functionality under extreme temperature is of particular importance for practical applications. Given that the organic memristors for artificial synapse applications are demonstrated under room temperature, achieving a robust device performance at extremely low or high temperature is still utterly challenging. In this work, the temperature issue is addressed by tuning the functionality of the solution‐based organic polymeric memristor. The optimized memristor demonstrates a reliable performance under both the cryogenic and high‐temperature environments. The unencapsulated organic polymeric memristor shows a robust memristive response under test temperature ranging from 77 to 573 K. Utilizing X‐ray photoelectron spectroscopy (XPS) and time‐of‐flight secondary‐ion mass spectrometry (ToF‐SIMS) depth profiling, the device working mechanism is unveiled by comparing the compositional profiles of the fresh and written organic polymeric memristors. A reversible ion migration induced by an applied voltage contributes to the characteristic switching behavior of the memristor. Herein, both the robust memristive response achieved at extreme temperatures and the verified device working mechanism will remarkably accelerate the development of memristors in neuromorphic systems.
Single‐Atom Nano‐Islands (SANIs): A Robust Atomic–Nano System for Versatile Heterogeneous Catalysis Applications
Authors: Li Zesheng , Li Bolin , Li Qingyu 
Published: March 2023

AbstractAcademician Tao Zhang from China and co‐workers designed the first Pt1/FeOx single‐atom catalysts (SACs) in 2011, and they proposed the concept of “single‐atom catalysis” in the field of heterogeneous catalysis. Generally, it is easy for active metal single‐atom sites on a carrier to migrate and aggregate, which results in poor performance; or the chemical bond between the metal atom and carrier is too strong (immovable), which results in passivation of the active site. Recently, “nano‐island” type SACs were designed, in which the active metal atoms are isolated on the “islands”, and can move within the respective “island”, but the migration across the “island” is blocked, to achieve a dynamic confinement design of single atoms (that is, a “moving but not aggregating” design philosophy). Herein, a new concept of “single‐atom nano‐islands (SANIs)” is proposed to describe these congeneric “atomic–nano” systems in heterogeneous catalysis fields. Particularly, the SANIs are divided into three categories: “one‐island–one‐atom”, “one‐island–multi‐atoms”, and “island–sea synergism” architectures. The scientific significance and application principles of SANIs in versatile heterogeneous catalysis fields (i.e., thermocatalysis, electrocatalysis, and photocatalysis) are summarized. The challenges and proposals of SANIs are also provided.
TexSe1–x Photodiode Shortwave Infrared Detection and Imaging
Authors: Fu Liuchong , He Yuming , Zheng Jiajia , Hu Yuxuan , Xue Jiayou , Li Sen , Ge Ciyu , Yang Xuke , Peng Meng , Li Kanghua , Zeng Xiangbin , Wei Jinchao , Xue Ding‐jiang , Song Haisheng , Chen Chao , Tang Jiang 
Published: March 2023

AbstractShort‐wave infrared detectors are increasingly important in the fields of autonomous driving, food safety, disease diagnosis, and scientific research. However, mature short‐wave infrared cameras such as InGaAs have the disadvantage of complex heterogeneous integration with complementary metal–oxide–semiconductor (CMOS) readout circuits, leading to high cost and low imaging resolution. Herein, a low‐cost, high‐performance, and high‐stability TexSe1–x short‐wave infrared photodiode detector is reported. The TexSe1–x thin film is fabricated through CMOS‐compatible low‐temperature evaporation and post‐annealing process, showcasing the potential of direct integration on the readout circuit. The device demonstrates a broad‐spectrum response of 300–1600 nm, a room‐temperature specific detectivity of 1.0 × 1010 Jones, a −3 dB bandwidth up to 116 kHz, and a linear dynamic range of over 55 dB, achieving the fastest response among Te‐based photodiode devices and a dark current density 7 orders of magnitude smaller than Te‐based photoconductive and field‐effect transistor devices. With a simple Si3N4 packaging, the detector shows high electric stability and thermal stability, meeting the requirements for vehicular applications. Based on the optimized TexSe1–x photodiode detector, the applications in material identification and masking imaging is demonstrated. This work paves a new way for CMOS‐compatible infrared imaging chips.
2D Perovskite Mn2+‐Doped Cs2CdBr2Cl2 Scintillator for Low‐Dose High‐Resolution X‐ray Imaging
Authors: Xu Haiping , Liang Wenqing , Zhang Zhizhuan , Cao Chi , Yang Wensheng , Zeng Hongmei , Lin Zhien , Zhao Dewei , Zou Guohong 
Published: March 2023

AbstractHigh‐performance X‐ray scintillators with low detection limits and high light yield are of great importance and are a challenge for low‐dose X‐ray imaging in medical diagnosis and industrial detection. In this work, the synthesis of a new 2D perovskite, Cs2CdBr2Cl2, via hydrothermal reaction is reported. By doping Mn2+ into the perovskite, a yellow emission located at 593 nm is obtained, and the photoluminescence quantum yield (PLQY) of Cs2CdBr2Cl2:5%Mn2+ perovskite reaches the highest value of 98.52%. The near‐unity PLQY and negligible self‐absorption of Cs2CdBr2Cl2:5%Mn2+ enable excellent X‐ray scintillation performance with a high light yield of 64 950 photons MeV−1 and low detection limit of 17.82 nGyair s−1. Moreover, combining Cs2CdBr2Cl2:5%Mn2+ with poly(dimethylsiloxane) to fabricate a flexible scintillator screen achieves low‐dose X‐ray imaging with a high resolution of 12.3 line pairs (lp) mm−1. The results suggest that Cs2CdBr2Cl2:5%Mn2+ is a promising candidate for low‐dose and high‐resolution X‐ray imaging. The study presents a new approach to designing high‐performance scintillators through metal‐ion doping.
PF6− Pseudohalides Anion Based Metal‐Free Perovskite Single Crystal for Stable X‐Ray Detector to Attain Record Sensitivity
Authors: Li Zhizai , Li ZhenHua , Peng Guoqiang , Shi Chang , Wang Haoxu , Ding San‐Yuan , Wang Qian , Liu Zitong , Jin Zhiwen 
Published: March 2023

AbstractMetal‐free perovskites (MFPs) possess excellent photophysical properties of perovskites while avoiding the introduction of toxic metal ions and organic solvents, and have been expanded to X‐ray detection. However, iodine‐based high‐performance MFPs are tended to oxidation, corrosion, and uncontrolled ion migration, resulting in poor material stability and device performance. Herein, the strongly electronegative PF6− pseudohalide is used to fabricate the large‐size MDABCO‐NH4(PF6)3 (MDBACO = methyl‐N′‐diazabicyclo[2.2.2]octonium) single crystals (SCs) for solving the problems of iodine ions. After the introduction of PF6− pseudohalides, the Coulomb interaction and hydrogen bonding strength are enhanced to alleviate the ion‐migration and stability problems. Moreover, combined with theoretical calculations, PF6− pseudohalides increase the ion‐migration barrier, and affect the contribution of its components to the energy band for a broadening bandgap. Meanwhile, the improved physical properties, such as large activation energy of ionic migration, high resistivity, and low current drift, further expand its application in low‐dose and sensitive X‐ray detection. Finally, the X‐ray detector based on MDABCO‐NH4(PF6)3 SCs achieves a sensitivity of 2078 µC Gyair−1 cm−2 (highest among metal‐free SCs‐based detectors) and the lowest detectable dose rate (16.3 nGyair s−1). This work has expanded the selection of MFPs for X‐ray detectors and somewhat advanced the development of high‐performance devices.
On the Electroluminescence Turn‐On Mechanism of Blue Quantum‐Dot Light‐Emitting Diodes
Authors: Zhang Huimin , Bai Jialin , Zhu Xiaoxiang , Xue Xulan , Zhang Hanzhuang , Zhou Mi , Ji Wenyu 
Published: March 2023

AbstractA clear understanding on the fundamental working mechanisms of quantum‐dot light emitting diodes (QLEDs), especially the blue devices, is always sought after. Here the electroluminescence (EL) turn‐on mechanism of blue QLEDs is unraveled by structure engineering of the hole‐transport layers (HTLs). It is demonstrated that the EL turn‐on in blue QLEDs is highly dependent on the charge‐transport polarity of the HTLs. Energy transfer between HTLs and the blue quantum dots (QDs) occurs for the QLEDs based on bipolar HTLs, and, in contrast, charge injection is responsible for EL turn‐on of the blue devices consisting of unipolar HTLs. In addition, large hole‐injection barrier results in serious accumulation of holes at the interface of HTLs/QDs, then inducing serious electrons leakage into the HTLs, thereby leading to poor device efficiency under low driving current. It is suggested here that confining the carriers to the quantum dots and reducing the hole‐injection barrier remain two critical aspects to optimize the performance of blue QLEDs.
Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis
Authors: Li Dan , Jiang Yucan , He Ping , Li Yeming , Wu Yan , Lei Wei , Liu Nanxin , de Bruijn Joost D. , Zhang Hua , Zhang Hongmei , Ji Ping , Yuan Huipin , Li Mingzheng 
Published: March 2023

AbstractHeterotopic ossification (HO) is a double‐edged sword. Pathological HO presents as an undesired clinical complication, whereas controlled heterotopic bone formation by synthetic osteoinductive materials shows promising therapeutic potentials for bone regeneration. However, the mechanism of material‐induced heterotopic bone formation remains largely unknown. Early acquired HO being usually accompanied by severe tissue hypoxia prompts the hypothesis that hypoxia caused by the implantation coordinates serial cellular events and ultimately induces heterotopic bone formation in osteoinductive materials. The data presented herein shows a link between hypoxia, macrophage polarization to M2, osteoclastogenesis, and material‐induced bone formation. Hypoxia inducible factor‐1α (HIF‐1α), a crucial mediator of cellular responses to hypoxia, is highly expressed in an osteoinductive calcium phosphate ceramic (CaP) during the early phase of implantation, while pharmacological inhibition of HIF‐1α significantly inhibits M2 macrophage, subsequent osteoclast, and material‐induced bone formation. Similarly, in vitro, hypoxia enhances M2 macrophage and osteoclast formation. Osteoclast‐conditioned medium enhances osteogenic differentiation of mesenchymal stem cells, such enhancement disappears with the presence of HIF‐1α inhibitor. Furthermore, metabolomics analysis reveals that hypoxia enhances osteoclastogenesis via the axis of M2/lipid‐loaded macrophages. The current findings shed new light on the mechanism of HO and favor the design of more potent osteoinductive materials for bone regeneration.
Toward Enhanced Aerosol Particle Adsorption in Never‐Bursting Bubble via Acoustic Levitation and Controlled Liquid Compensation
Authors: Ji Xiaoliang , Jiang Pingsong , Jiang Yichen , Chen Hongyue , Wang Weiming , Zhong Wenxuan , Zhang Xiaoqiang , Zhao Wei , Zang Duyang 
Published: March 2023

AbstractBubbles in air are ephemeral because of gravity‐induced drainage and liquid evaporation, which severely limits their applications, especially as intriguing bio/chemical reactors. In this work, a new approach using acoustic levitation combined with controlled liquid compensation to stabilize bubbles is proposed. Due to the suppression of drainage by sound field and prevention of capillary waves by liquid compensation, the bubbles can remain stable and intact permanently. It has been found that the acoustically levitated bubble shows a significantly enhanced particle adsorption ability because of the oscillation of the bubble and the presence of internal acoustic streaming. The results shed light on the development of novel air‐purification techniques without consuming any solid filters.
In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction
Authors: D'Alessandro Angelo , Nouraie S. Mehdi , Zhang Yingze , Cendali Francesca , Gamboni Fabia , Reisz Julie A. , Zhang Xu , Bartsch Kyle W. , Galbraith Matthew D. , Gordeuk Victor R. , Gladwin Mark T. 
Published: March 2023

AbstractDespite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD), no study to date has evaluate a large and well phenotyped cohort to compare the primary erythrocyte metabolome of hemoglobin SS, SC and transfused AA red blood cells (RBCs) in vivo. The current study evaluates the RBC metabolome of 587 subjects with sickle cell sickle cell disease (SCD) from the WALK‐PHaSST clinical cohort. The set includes hemoglobin SS, hemoglobin SC SCD patients, with variable levels of HbA related to RBC transfusion events. Here we explore the modulating effects of genotype, age, sex, severity of hemolysis, and transfusion therapy on sickle RBC metabolism. Results show that RBCs from patients with Hb SS genotypes—compared to AA RBCs from recent transfusion events or SC RBCs—are characterized by significant alterations of RBC acylcarnitines, pyruvate, sphingosine 1‐phosphate, creatinine, kynurenine and urate metabolism. Surprisingly, the RBC metabolism of SC RBCs is dramatically different from SS, with all glycolytic intermediates significantly elevated in SS RBCs, with the exception of pyruvate. This result suggests a metabolic blockade at the ATP‐generating phosphoenolpyruvate to pyruvate step of glycolysis, which is catalyzed by redox‐sensitive pyruvate kinase. Metabolomics, clinical and hematological data were collated in a novel online portal. In conclusion, we identified metabolic signatures of HbS RBCs that correlate with the degree of steady state hemolytic anemia, cardiovascular and renal dysfunction and mortality.
Multi‐Site Conformational Exchange in the Synthetic Neomycin‐Sensing Riboswitch Studied by 19F NMR
Authors: Overbeck Jan H. , Vögele Jennifer , Nussbaumer Felix , Duchardt‐Ferner Elke , Kreutz Christoph , Wöhnert Jens , Sprangers Remco 
Published: March 2023

AbstractThe synthetic neomycin‐sensing riboswitch interacts with its cognate ligand neomycin as well as with the related antibiotics ribostamycin and paromomycin. Binding of these aminoglycosides induces a very similar ground state structure in the RNA, however, only neomycin can efficiently repress translation initiation. The molecular origin of these differences has been traced back to differences in the dynamics of the ligand:riboswitch complexes. Here, we combine five complementary fluorine based NMR methods to accurately quantify seconds to microseconds dynamics in the three riboswitch complexes. Our data reveal complex exchange processes with up to four structurally different states. We interpret our findings in a model that shows an interplay between different chemical groups in the antibiotics and specific bases in the riboswitch. More generally, our data underscore the potential of 19F NMR methods to characterize complex exchange processes with multiple excited states.
Manganese(I) Catalyzed ortho C−H Allylation of Benzoic Acids
Authors: Goebel Jonas F. , Stemmer Johanna , Belitz Florian , Gooßen Lukas J. 
Published: March 2023

AbstractThe 3d‐metal catalyst Mn(CO)5Br was found to efficiently promote ortho C−H allylations of arenecarboxylates in the presence of neocuproine as the ligand. Despite the simplicity of directing group and catalyst system, the selectivity goes well beyond the state‐of‐the‐art in that mono‐allylated products are obtained exclusively with high selectivities for the least hindered ortho‐position. The directing group can optionally be removed by in situ decarboxylation, opening up a regioselective entry to allyl arenes. The preparative utility of the process and its othogonality to other approaches was demonstrated by 44 products with otherwise hard‐to‐access substitution patterns, including 3‐bromo‐allylbenzene, 3‐allylbenzofuran, or 5‐allyl‐2‐methylnitrobenzene.
Comprehensive Study of the Enhanced Reactivity of Turbo‐Grignard Reagents**
Authors: Hermann Andreas , Seymen Rana , Brieger Lukas , Kleinheider Johannes , Grabe Bastian , Hiller Wolf , Strohmann Carsten 
Published: March 2023

AbstractSince its introduction in 2004, Knochel's so called Turbo‐Grignard reagents revolutionized the usage of Grignard reagents. Through the simple addition of LiCl to a magnesium alkyl an outstanding increase in reactivity can be achieved. Though the exact composition of the reactive species remained mysterious, the reactive mixture itself is readily used not only in synthesis but also found its way into more distant fields like material science. To unravel this mystery, we combined single‐crystal X‐ray diffraction with in‐solution NMR‐spectroscopy and closed our investigations with quantum chemical calculations. Using such a variety of methods, we have gained insight into and an explanation for the extraordinary reactivity of this extremely convenient reagent by determining the structure of the first bimetallic reactive species [t‐Bu2Mg ⋅ LiCl ⋅ 4 thf] with two tert‐butyl anions at the magnesium center and incorporated lithium chloride.
Recent advances of Raman spectroscopy for the analysis of bacteria
Authors: Rodriguez Linsey , Zhang Zhiyun , Wang Danhui 
Published: March 2023

AbstractRapid and sensitive bacteria detection and identification are becoming increasingly important for a wide range of areas including the control of food safety, the prevention of infectious diseases, and environmental monitoring. Raman spectroscopy is an emerging technology which provides comprehensive information for the analysis of bacteria in a short time and with high sensitivity. Raman spectroscopy offers many advantages including relatively simple operation, non‐destructive analysis, and information on molecular differences between bacteria species and strains. A variety of biochemical properties can be measured in a single spectrum. This short review covers the recent advancements and applications of Raman spectroscopy for bacteria analysis with specific focuses on bacteria detection, bacteria identification and discrimination, as well as bacteria antibiotic susceptibility testing in 2022. The development of novel substrates, the combination with other techniques, and the utilization of advanced data processing tools for the improvement of Raman spectroscopy and future directions are discussed.
Hydrothermal fabrication of novel nanocomposites Mx‐MoO3‐α‐NaFe2(MoO4)3‐α‐FeMoO4 (M = Al, Co, Ni, and Er) for highly efficient catalytic synthesis of 5‐aryl‐1H‐tetrazole analogs
Authors: Taherzad Neda , Kafi‐Ahmadi Leila , Poursattar Marjani Ahmad 
Published: March 2023

Mx‐MoO3‐α‐NaFe2(MoO4)3‐α‐FeMoO4 (M = Al, Co, Ni, and Er) nanomaterials were fabricated by the hydrothermal method in the present study. XRPD, FESEM, TEM, BET‐BJH, UV‐Vis, and VSM analyses were used to characterize and study the physical attributes of the as‐synthesized samples. Rietveld analysis data illustrated that the products were a mixture of α‐NaFe2(MoO4)3, α‐FeMoO4, MoO3, and Fe2O3 crystal phases. UV‐Vis spectra indicated that the obtained samples had a small direct band gap energy amount at about 1.3–1.5 eV. VSM analysis confirmed that the as‐fabricated samples had magnetic properties. However, most ferromagnetic behaviors were observed by doping Ni into the host crystal system. Catalytic synthesis of some 5‐aryl‐1H‐tetrazole analogs was performed under heat, microwave, and ultrasonic conditions. Reaction time, temperature, and solvent type parameters were studied to find the optimum conditions. High efficiency was obtained when ethyl alcohol was used as the reaction mixture solvent.