bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis and Cytotoxic Studies of Novel 4-anilinoquinazoline Derivatives of Potential Agents for Non-small-cell Lung Cancer
Authors: Dwivedi Deepak K. , Agrawal Ram Kishore , Jain Sanyog , Kuche Kaushik 
Published: May 2023

Background:
The pre-existing EGFR (Epidermal Growth Factor Receptors) inhibitors (Gefitinib,
Afatinib and osimertinib) show significant resistance after one year of EGFR therapy in NSCLC
(Non-small cell lung cancer) patients. With the aim of overcoming the resistance problem associated with
a current therapeutic regimen, there is an imperative need for the development of novel 4-
anilinoquinazoline derivatives that are specifically designed for resistance cases of NSCLC patients.

Objective:
We designed and synthesized eighteen 4-anilinoquinazolines derivatives as a novel scaffold
and evaluated their anti-cancer potential against different NSCLC cell lines.

Methods:
Molecular docking study of designed compounds were performed on Glide v5.8 (Schrodinger,
LLC, New York, NY). Synthesis of 4-anilinoquinazoline derivatives were performed, based on the docking
score and was characterized by various spectroscopic methods. Further, in vitro anti-cancer activity
was performed using MTT assay on different cancer cell lines.

Results:
Molecular docking analysis [EGFRT790M mutant (4I22)] indicated that most of these analogs (6g,
6j, 6l, 6m and 6o) were found to be higher docking scores than gefitinib. Furthermore, spectral analysis
revealed that the designed compounds were synthesized successfully. The compounds 6a, 6d, 6g, 6i, 6j
and 6m were identified as the potent inhibitors against (A431, H1975, A549) cell lines as compared to
reference standard gefitinib. Excitingly, compound 6j (with IC50 values of 4.88 ± 0.13, 4.38 ± 0.08 &
11.97 ± 0.14 μM) was identified as the most potent inhibitor for (A431, H1975, A549) cell lines.

Conclusion:
The study suggested that the six derivatives showed significant therapeutic potential against
different NSCLC cell lines as compared to reference standard gefitinib.
Zinc Acetate in Organic Synthesis and Catalysis: A Review
Authors: Alam Mohammed Mujahid , Varala Ravi , Seema Vittal 
Published: May 2023

Abstract:
Among the many zinc salts that can be found, zinc acetate is one of the readily available,
affordable, low-hazardous Lewis acids. It can be referred to as a multifunctional catalyst due to its
unique physical and chemical properties, which show that they are effective in enabling a variety of
synthetic transformations in both organic synthesis and catalysis. This review included noteworthy
innovations that have been created during the past two and half decades using zinc acetate as a catalyst
or reagent.
The Decline in the Age of Onset of Puberty – A Source of Concern
Authors: Mangla Mishu 
Published: May 2023

Abstract:
Puberty refers to physical transitions that occur in the body of adolescents, taking them
from a stage of sexual immaturity to sexual maturity. Nowadays, it is being observed that more and
more girls are attaining menarche at an age less than ten years, so the age of onset of Puberty being
somewhere around 7.5 to 8 years. The reasons and implications are manifold. Early age of onset of
puberty is a risk factor for ovarian and breast malignancies and also for a number of chronic diseases.
The present article expresses author’s opinion regarding the issue on the basis of recent literature and
tries to highlight the reasons responsible for this, especially in the current scenario and discusses modifiable
factors so that the process can be halted.
Legal-Jurisprudential Protection of Women in Cases of Spousal Unauthorized
Psychological-Verbal Domestic Violence, A Narrative Review
Study
Authors: Ghodrati Fatemeh 
Published: May 2023

Background:
Intimate partner violence [IPV) in all its physical, mental, overt and covert
forms is an important issue in terms of its consequences.

Objective:
This study aimed to provide legal-jurisprudential support for women in cases of spousal
abuse and unauthorized psychological violence.

Material and Methods:
This review article is the result of reviewing the published evidence on the
supportive aspects of unauthorized psychological-verbal IPV between 1995 and 2021 in Magiran,
SID, Iranmedex Persian databases, and in Scopus, PubMed, Science Direct, and EBSCO English databases. To gather information first, articles and jurisprudential texts containing one of the words “verbal violence, domestic violence, spousal abuse, legal protection of women, law, Islam” in the title or
text, alone or in combination, were searched for.

Results:
Twenty-three out of 58 studies related to legal-jurisprudential support for women in Iran in
cases of psychological-verbal IPV were reviewed. Verbal psychological IPV, attack on the spiritual
status of the wife, accusing the wife of sexual infidelity, insulting, using inappropriate instincts, harshness, humiliation, intimidation and misbehavior, the verbal threat of harassment, and even threat of
murder, etc., were the instances of such violence. The Shari’a supported the wife with punishments of
Solemn Imprecation, imprisonment, lashes, and fines.

Conclusion:
In addition to the current legal solutions, the main legal gap that causes the ineffectiveness of laws and the violation of women’s rights is the solution and removal of obstacles that, in practice and in court, have made it difficult to prove psychological-verbal violence against women at
home.
Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and
Therapeutic Potential
Authors: Tiwari Abhishek , Tiwari Varsha , Banik Bimal Krishna , Sahoo Biswa Mohan 
Published: May 2023

Abstract:
Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent
catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6-
tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation,
superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective,
protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention,
respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five
major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions
catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports
the use of TP which may be proven as a “MIRACLE” drug for the treatment of numerous disorders
namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well
as in covid. It also possesses a significant role in minimising side effects in combination therapy.
This review will be beneficial to researchers, healthcare, and academic professionals for further
research.
A Complete Sojorum on Thermosensitive Hydrogels for Wound Healing:
Recent Developments and Ongoing Research
Authors: Markandeywar Tanmay Sudhakar , Singh Dilpreet , Narang Raj Kumar 
Published: May 2023

Abstract:
The nature of the wound typically dictates the available wound-healing therapies. On the
other hand, inadequate care results in persistent wounds, fibrosis, tissue loss of function, and ultimately
dismemberment. Suturing, unloading, irrigation, debridement, negative pressure therapies, growth
factor supplementation, and grafting are examples of current medicines that all have limitations in
terms of meeting the needs of full treatment. Natural or synthetic materials/polymers have been utilized
to prepare smart thermosensitive hydrogels to facilitate quick and targeted action on wounds.
These are intelligent hydrogel system that shows sol-gel transitions at physiological body temperature.
Hydrogel provides a moist environment, scaffold-like structure, and localized delivery of drug/growth
factor that speed up wound healing even if it eliminates side effects associated with systemic administration.
In this article, we summarized the detailed mechanisms of wound healing, conventional
strategies, and ongoing thorough research work in the field of thermosensitive hydrogels utilized for
wound healing. Moreover, the clinical needs of this formulation, as evident from the commercially
available systems are also described in the prior art.
Patent Technology of Shipborne Stabilized Platform
Authors: Zou Yuxin , Liu Hongbo , Liu Xianli , Yang Xiao Dong 
Published: May 2023

Background:
When a ship is sailing or operating at sea, it is unavoidable to produce sixdegrees-
of-freedom movements of rolling, pitching, and yawing under the action of sea wind and
waves, which seriously impacts the operation of precision equipment on the ship and the safety of
personnel. The ship-borne stabilized platform can isolate the ship's motion and eliminate the impact
of sea waves on the personnel and equipment on it to a large extent. With the increasing demand for
ship surfaces in marine fields, such as navigation equipment, military facilities, and sea condition
simulation, there is an urgent need to study ship-borne platforms with high stability and efficiency
to isolate swaying and ensure ship performance.

Objective:
This study aims to analyse the patents and summarize the characteristics and existing
problems of the shipborne platform to provide a reference for the future development of the shipborne
stabilized platform.

Methods:
Various representative patents related to shipborne stabilized platforms and multi-DOF
platforms were researched in this study.

Results:
Through the analysis and comparison of patent technology, the main problems existing in
the structure and design principle of the existing shipborne stabilized platform are summarized, and
the development trend and direction of the shipborne stabilized platform are discussed.

Conclusion:
Shipborne stabilization is highly significant in isolating the ship's motion. At present,
the ship-borne stabilized platform has produced six degrees of freedom of movement, but due to the
improvement of control response requirements, the structure of the platform needs to be further improved.
With the development of test technology toward intelligent and big data-driven technology,
the shipborne stabilized platform is moving toward cloud computing and large-scale testing.
Adherence to Patient-Reported Symptom Monitoring and Subsequent Clinical Interventions for Patients With Multiple Myeloma in Outpatient Care: Longitudinal Observational Study
Authors: Lehmann Jens , de Ligt Kelly M , Tipelius Stefanie , Giesinger Johannes M , Sztankay Monika , Voigt Sandra , van de Poll-Franse Lonneke V , Rumpold Gerhard , Weger Roman , Willenbacher Ella , Willenbacher Wolfgang , Holzner Bernhard 
Published: May 2023

Background
The use of software to monitor patient-reported outcome measures (PROMs) can improve outcomes for patients with cancer receiving anticancer therapy; however, evidence from applications used in routine clinical practice is lacking.

Objective
We aimed to investigate adherence to and patient perceptions of a weekly, web-based PROM symptom monitoring program in routine clinical practice for patients with Multiple Myeloma. Moreover, we aimed to capture how clinical alerts prompted by the system influenced clinical care.

Methods
We conducted a single-center longitudinal observational study to evaluate patient adherence to and perceptions of the PROM monitoring software in routine practice. Patients with Multiple Myeloma remotely completed weekly treatment-specific PROMs to monitor key symptoms via a dedicated web-based platform. Alarming symptoms triggered clinical alerts in the application for the treatment team, which could initiate clinical interventions. The primary outcomes were the web-based assessment completion rate and patients’ perceptions of the monitoring program, as assessed by an evaluation questionnaire. Moreover, clinical alerts prompted by the system and consequential clinical interventions were analyzed.

Results
Between July 2021 and June 2022, a total of 55 patients were approached for participation; 39 patients participated (24, 61% male, mean age 63.2, SD 9.2 years). The median assessment completion rate out of all weekly scheduled assessments was 70.3% (IQR 41.2%-89.6%). Most patients (77%) felt that the health care team was better informed about their health status due to the web-based assessments. Clinical alerts were triggered for 1758 of 14,639 (12%) reported symptoms. For 548 of 1758 (31.2%) alerts, the symptom had been registered before and no further action was required; for 348 of 1758 (19.9%) alerts, telephone consultation and self-management advice sufficed. Higher-level interventions were seldom needed in response to alerts: referral to a doctor or specialist (88/1758, 5% alerts), medication changes (22/1758, 1.3%), scheduling additional diagnostics (9/1758, 0.5%), or unplanned emergency visits (7/1758, 0.4%). Most patients (55%) reported the calls in response to alerts gave them “quite a bit” or “very much” of an added feeling of security during therapy.

Conclusions
Our study shows that high adherence to regular and tailored PROM monitoring can be achieved in routine clinical care. The findings provide valuable insight into how the PROM monitoring program and the clinical alerts and resulting interventions shaped clinical practice.

Trial Registration
ClinicalTrials.gov NCT05036863; https://clinicaltrials.gov/study/NCT05036863
Methodologies for Monitoring Mental Health on Twitter: Systematic Review (Preprint)
Authors: Di Cara Nina H , Maggio Valerio , Davis Oliver S P , Haworth Claire M A 
Published: May 2023

BACKGROUND

The use of social media data to predict mental health outcomes has the potential to allow for the continuous monitoring of mental health and well-being and provide timely information that can supplement traditional clinical assessments. However, it is crucial that the methodologies used to create models for this purpose are of high quality from both a mental health and machine learning perspective. Twitter has been a popular choice of social media because of the accessibility of its data, but access to big data sets is not a guarantee of robust results.

OBJECTIVE

This study aims to review the current methodologies used in the literature for predicting mental health outcomes from Twitter data, with a focus on the quality of the underlying mental health data and the machine learning methods used.

METHODS

A systematic search was performed across 6 databases, using keywords related to mental health disorders, algorithms, and social media. In total, 2759 records were screened, of which 164 (5.94%) papers were analyzed. Information about methodologies for data acquisition, preprocessing, model creation, and validation was collected, as well as information about replicability and ethical considerations.

RESULTS

The 164 studies reviewed used 119 primary data sets. There were an additional 8 data sets identified that were not described in enough detail to include, and 6.1% (10/164) of the papers did not describe their data sets at all. Of these 119 data sets, only 16 (13.4%) had access to ground truth data (ie, known characteristics) about the mental health disorders of social media users. The other 86.6% (103/119) of data sets collected data by searching keywords or phrases, which may not be representative of patterns of Twitter use for those with mental health disorders. The annotation of mental health disorders for classification labels was variable, and 57.1% (68/119) of the data sets had no ground truth or clinical input on this annotation. Despite being a common mental health disorder, anxiety received little attention.

CONCLUSIONS

The sharing of high-quality ground truth data sets is crucial for the development of trustworthy algorithms that have clinical and research utility. Further collaboration across disciplines and contexts is encouraged to better understand what types of predictions will be useful in supporting the management and identification of mental health disorders. A series of recommendations for researchers in this field and for the wider research community are made, with the aim of enhancing the quality and utility of future outputs.

CLINICALTRIAL
La fe cristiana como horizonte de sentido ante la crisis migratoria
Authors: Guerrero Guerrero Vinicio Renato 
Published: May 2023

A critical reflection is made on the current migratory crisis and examines the causes and consequences that have shocked the world today, sharpening its wounds. The analysis focuses on the importance of Christian faith which, in front of the humanitarian crisis, the proliferation of xenophobic discourse, and the tendency to increasingly exclude migrants and refugees has taken an option for these vulnerable people. Inspired by the word of God and the Gospel of Christ, it not only defends migrants' dignity, but also works tirelessly for its promotion and full humanization, recognizing in them the image of Christ and a sign of God's visit to the world at present. In fact, this study aims to show how faith is able to generate a horizon of sense, salvation, and hope in the middle of the current crisis and favor a liberating rereading, a reinterpretation of the sense of life for a group of migrants at Hogar de Cristo Foundation in Guayaquil.
Performance simulation of water turbines by using 6-DoF UDF and sliding mesh methods
Authors: Chica Arrieta Edwin Lenin , Betancour Johan , Velásquez Laura , Rubio Clemente Ainhoa 
Published: May 2023

In this work, a comparison between the six degrees of freedom (6-DoF) method and the sliding mesh approach in computational fluid dynamics simulations of an Archimedes screw turbine for hydrokinetic applications was performed using ANSYs Fluent software. The numerical curves obtained by representing the power coefficient () values versus the tip speed ratio ( or ) were compared based on the experimental data available in the literature. Therefore, by considering the values as the comparison benchmark parameter between the numerical and experimental data, the error obtained when using the 6-DoF method and the sliding mesh approach was 13% and 40%, respectively. Both methods allowed the simulation of the rotor rotation, although the 6-DoF method was more accurate in the prediction of the turbine performance, higher computational resources were consumed in comparison with the sliding mesh method, which allows to obtain a computational solution in affordable times.
"VOA VOA MARIA" E AS PERFORMANCES DO TEMPO ESPIRALAR
Authors: Vieira Thaís Aparecida Pellegrini 
Published: May 2023

Neste breve percurso investigativo, a proposta que aqui desenho se curva às experiências rítmicas e estéticas das músicas e performances do samba de roda Voa Voa Maria, de Matarandiba. Por esse prisma, em primeira instância, tomarei algumas chaves analíticas, sendo que, dentre elas, destaco a concepção de tempo espiralar desenvolvida pela professora Leda Maria Martins (2021), numa perspectiva cósmico-filosófica da ancestralidade africana. Através do samba e seu território, a comunidade indica que suas enunciações poéticas conseguem fissurar a linearidade temporal hierarquizante do Chronos ocidentalizado, já que as vivências estéticas, através dessas vozes, corpos e tambores, estão em funcionamento de um tempo não linear, mas sim curvilíneo. Destarte, a tríade: corpo-tempo-movimento atua como prenuncio da potência literária presente no samba da localidade. No primeiro momento do texto, aporto em Itaparica, nas beiradas da maré matarandibense, e faço uma mostra desse cenário que inscreve o protagonismo e pertencimento local. Nessa perspectiva, as riquezas naturais gravitam como elementos vivos dessa poética contracosteira da ilha de Itaparica. Minha âncora será fincada em pensadoras e pensadores que permitam a percepção dos saberes imbricados na indagação proposta. Trago Krenak (2020), dialogando sobre a importância da Terra como ser ativo, bem como seus entrelaces com as humanidades, a fim de pensar a paisagem e o processo de ressignificação que é feito pela comunidade, capaz de subverter a ideia de subalternidade que permeia os cenários da contracosta. Martins (2020, 2021), Oyěwùmí, (2021), Sodré (1998, 2020), Zumthor (2000) os quais ajudarão a modular a relação corpo-tempo-movimento em face às possíveis simultaneidades que reativam e reinstauram esses corpos subalternizados como “tapeçaria de sentidos discursivos” (MARTINS, 2021, p.21). Freitas (2016) nos permitirá fazer um exercício crítico literário operando o conceito de literatura-terreiro que, segundo o autor, “é aquela que, dentro da cosmogonia africana e/ou afro-brasileira explora a multimodalidade” (FREITAS, 2016, p.59). Com ele, será possível aferir acepções críticas nodais apontando o vigor do samba Voa Voa Maria como literatura.
Zakat Maal, Masjid, dan Kesejahteraan: Lembaga Pengelola Zakat Masjid Nurul Iman, Ukui, Indonesia
Authors: Winatri Winatri , Alhidayatillah Nur , Perdamaian Perdamaian 
Published: May 2023

Tujuan penelitian ini mengkaji tentang bagaimana strategi pendistribusian zakat maal yang dilakukan oleh lembaga pengelola zakat (LPZ) di Masjid Nurul Iman Kecamatan Ukui. Penelitian ini menggunakan metode deskriptif kualitatif dan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. Adapun narasumber pada penelitian ini berjumlah 4 orang yaitu ketua LPZ, wakil ketua, sekretaris, dan tim survei. Mereka adalah orang-orang yang memiliki kapabilitas serta mengetahui informasi terkait data dalam penelitian ini. Agar pendistribusian berjalan lancar pengurus lembaga pengelola zakat di Masjid Nurul Iman perlu merumuskan strategi. Salah satu strategi yang dilakukan yaitu menentukan target mustahik secara tepat. Lembaga pengelola zakat di Masjid Nurul Iman melakukan survei secara langsung. Ihwal ini untuk menilai kelayakan mustahik. Adapun strategi pendistribusiannya yaitu dengan bantuan konsumtif berupa bahan pangan, bantuan pendidikan, bantuan kesehatan dan program bedah rumah. Sedangkan pendistribusian zakat secara produktif yaitu dengan memberikan bantuan modal usaha kepada mustahik.
Persepsi Orang Tua Terhadap Pendidikan Tinggi bagi Anak Perempuan
Authors: Tismini Tismini , Susilawati Nora 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui faktor penyebab orang tua mempersepsikan bahwa pendidikan tinggi tidak penting bagi anak perempuan di Jorong II Sungai Lolo. Kabupaten Pasaman. Hal ini menarik untuk diteliti karena adanya minat anak perempuan yang tinggi untuk kuliah, apalagi setelah adanya guru pendatang perempuan, namun orang tua memiliki persepsi bahwa anak perempuan tidak perlu mengeyam pendidikan di universitas karena kodratnya akan menjadi ibu rumah tangga, yang memupus harapan anak perempuan untuk kuliah dan mendapatkan pekerjaan yang tepat sesuai keinginannya. Untuk meneliti permasalahan tersebut, digunakan penelitian kualitatif dengan tipe penelitian studi kasus instrinsik. Informan dalam peneltian ini berjumlah 15 orang yang diperoleh dengan cara purposive sampling. Pengumpulan data dilakukan dengan metode observasi, wawancara dan studi dokumentasi. Data tersebut kemudian di analisis dengan model analisis interaktif yang dikembangkan oleh Miles dan Hubberman. Data yang diperoleh kemudian dianalisis menggunakan teori fenomenologi dari Alfred Schutz berasumsi bahwa orang-orang secara aktif menginterpretasikan pengalaman-pengalamannya dan mencoba memahami dunia dengan pengalaman pribadinya. Hasil penelitian menunjukkan bahwa adanya persepsi orang tua terhadap pendidikan tidak penting untuk anak perempuan terbentuk karena pengetahuan dan pengalaman bahwa kodrat perempuan hanya bekerja di rumah, dan laki-laki yang bekerja di luar rumah, oleh karena itu laki-laki perlu sekolah tinggi, sedangkan perempuan tidak, perempuan yang sekolah tinggi memiliki kemungkinan untuk memperoleh jodoh di luar daerahnya dan tidak kembali ke kampung, perempuan yang mengurus rumah tangga tidak memerlukan pendidikan yang tinggi, serta pengalaman dilarang oleh orang tua untuk sekolah tinggi.