bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Patients with Brain Metastases Referred to Palliative Care
Authors: Harrison Rebecca Anne , Tang Michael , Shih Kaoswi Karina , Khan Maria , Pham Lily , De Moraes Aline Rozman De Moraes Rozman , O’Brien Barbara J , Bassett Roland , Bruera Eduardo 
Published: December 2022

Abstract
Purpose: In this study, we aimed to assess the clinical characteristics, reasons for referral, and outcomes of patients with brain metastases (BM) referred to the supportive care center.
Methods: Equal numbers of patients with melanoma, breast cancer, and lung cancer with (N=90) and without (N=90) BM were retrospectively identified from the supportive care database for study. Descriptive statistics were used to analyze demographic, disease, and clinical data. Kaplan Meier method was used to evaluate survival outcomes.
Results: While physical symptom management was the most common reason for referral to supportive care for both patients with and without BM, patients with BM had significantly lower pain scores on ESAS at time of referral (p=0.002). They had greater interaction with acute care in the last weeks of life, with higher rates of ICU admission, emergency room visits, and hospitalizations after initial SC visit. The median survival time from referral to SCC was 0.90 years (95% CI 0.73, 1.40) for the brain metastasis group and 1.29 years (95% CI 0.91, 2.29) for the group without BM.
Conclusions: Patients with BM have shorter survival and greater interaction with acute care in the last weeks of life. This population also has distinct symptom burdens from patients without BM. Strategies to optimize integration of SC for patients with BM warrant ongoing study.
WITHDRAWN: Porous biomass gel beads SA/CS/GO construction and bifunction tuning on adsorption and antibacterial properties
Authors: Wang Songtao , Feng Xiaohua 
Published: December 2022

Abstract
The organic dye molecules and pathogenic microorganisms exist widely in printing and dyeing wastewater which will bring severe harm to human beings and the water environment if they are not properly treated. A novel SA/CS/GO gel beads with both adsorption and antibacterial functions are synthesized in the special ways. NaHCO3 is selected as porogen to control the density of gel beads formed by the cross-linking of Ca2+. Ag+ is fixed on outside the beads to optimize the inactivation rate of typical strains. The morphology and composite of the beads are characterized through SEM and FT-IR spectrometer. The adsorption properties of the beads accord with the Langmuir isotherm and quasi-secondary model, that means, the adsorption is monolayer behavior and the reaction rate is controlled through the chemical reaction process. The theoretical adsorption liminal value of MB on the beads can reach 847.46 mg/g. In the range of pH value at 3–11, it also has good adsorption ability. After five rounds of adsorption-desorption experiments, the gel beads still remain favorable performance. At the same time, the sterilization rate of the beads is almost 100% for the selected typical strains, even after several adsorption-desorption cycles, it still has a good bactericidal function. So, this kind of new gel beads is easy to recycle, reusable, and has broad application foreground in the field of water purification, sterilization, and adsorption.
Real-Time Approximate and Combined 2D Convolvers for FPGA-based Image Processing
Authors: Ramezanzad Ali , Rezaei Mehran , Nikmehr Hooman , Kalbasi Mahdi 
Published: December 2022

Abstract
Convolution widely has been used as the main part of the improvement in digital image processing applications. In convolutional computations, a large number of memory accesses and a huge amount of computations challenge its performance. Many of the related proposed convolvers are based on exact computations. Although exact convolvers keep the accuracy of the convolution operation at the top level, sometimes by missing a negligible amount of accuracy, the performance can be improved. Approximate computing is a new technique for solving computation overhead problems. In this paper, approximate 2D convolvers are presented which minimize the memory access rate and computations by a special factor of Multiply-and-Accumulate (MAC) terms. On the other hand, to preserve the flexibility for supporting different required accuracy, the proposed approximate convolvers are combined with the exact designs with real-time pre-processing stages by exploiting innovative methods which manage the hardware overhead. In comparison to conventional convolvers, the proposed designs improve the number of active resources which causes a significant reduction in power consumption. For 3 × 3 kernel size, the evaluation results on the Xilinx Virtex-7 (XC7V2000t) FPGA device show 34% and 20% power optimization of the proposed approximate and combined convolvers respectively, in comparison to Exact Convolver (EC). Also, this improvement grows by increasing the kernel size. Finally, a comparison based on RMSE and PSNR for different sample images and filters reveals that the error rate and image quality reduction are acceptable for many real-time image processing applications.
Older Adults' User Experience with Introvert and Extravert Humanoid Robot Personalities
Authors: Zedda Eleonora , Manca Marco , Paternò Fabio , Santoro Carmen 
Published: December 2022

Abstract
Humanoid robots can be an effective tool for the cognitive training of older adults. For this purpose, it is important that their interaction be engaging. In this study, we investigate whether proposing robots exhibiting extraverted or introverted personalities can improve user experience. For this purpose, we have designed and implemented a set of multi-modal cues for such personality traits in an application proposing typical exercises for cognitive training through a Pepper robot. We report on a user test with 24 older adults (65+), which provided interesting and positive feedback regarding how the robot personalities have been exhibited and their impact on the experience of such users.
Cytotoxicity Studies and Structural Analysis of Newly Synthesized Schiff Base Thiadiazole Derivatives and Its Metal Complexes
Authors: Al-Aghbari Sama , Obeid Abeer , Al-Taifi Elham , Al-Kabodi Ebrahim , Ragih Zianab , Al-Shuja'a Omar 
Published: December 2022

Abstract
A Schiff base ligand [(E)-4-(((5-ethyl-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2,3-triol] (ETIMB) has been synthesized by condensation of an equimolar mixture of 5-Ethyl-1,3,4-thiadiazole-2-amino (0.01 mole) and 2,3,4-Trihydroxybenzaldehyde (0.01 mole) in absolute ethanol (25 ml). The ligand (ETIMB) was reacted with Ag(I), Ni(II), Cu(II) in ratio 1:1, 2:1, 2:1 respectively. The mixture was refluxed for 24 hrs. The Schiff base and its complexes were characterized by elemental (CHN) analysis, FTIR, electronic spectra,1HNMR spectra and Mass spectra. All complexes were screened for their in vitro anticancer potential using HeLa and PC3 cells. Cu(II) complex showed excellent cytotoxic activity towards HeLa cells.
First report on the presence of the huanglongbing vectors in Ghana
Authors: Aidoo Owusu Fordjour , Ablormeti Fred K. , Ninsin Kwodwo D. , Antwi-Agyakw Akua K. , Osei-Owusu Jonathan , Heve William K. , Dufour Aboagye K. , Soto Yovanna L. , Edusei George , Osabutey Angelina F. , Sosa Frederick L. , Aryee Clement O. , Alabi Olufemi J. , Setamou Mamoudou 
Published: December 2022

Abstract
As significant threats to global citrus production, Diaphorina citri (Kuwayama; Hemiptera: Liviidae) and Trioza erytreae (Del Guercio; Hemiptera: Triozidae) have caused considerable losses to citrus trees globally. Diaphorina citri vectors “Candidatus Liberibacter asiaticus” and “Ca. L. americanus”, the causative agents implicated in Asian Huanglongbing (HLB), whereas T. erytreae transmits “Ca. L. africanus”, the pathogen responsible for the African form of the disease. Though HLB is the deadliest disease of citrus wherever it occurs, information on the occurrence and geographical distribution of its vectors in Africa is limited. In recent surveys to determine if HLB vectors are present in Ghana, we observed eggs, nymphs, and adults of insects suspected to be D. citri and T. erytreae. Using morphological traits and DNA analyses, the identity of the adult and nymphal stages of the suspected insects was confirmed to be D. citri and T. erytreae, respectively. Individuals of D. citri and T. erytreae were examined using qPCR for CLaf, CLam, and CLas, but none of them tested appositive for any of the Liberibacter species. Herein we report, for the first time, the presence of D. citri and T. erytreae in Ghana (West Africa). We discuss the implications of this new threat to the citrus industry to formulate appropriate management strategies.
Modelling the Energy Flow from Landscape Gradients to Mosaics via the First Law of Thermodynamics
Authors: CHENG Xinghua , LI Zhilin 
Published: December 2022

Abstract
Context: Thermodynamics is believed to be as the essential cornerstone for characterizing and understanding the dynamics of landscape ecology. The work and energy flow in the thermodynamic process of landscape ecology is studied with aid of the thermodynamic entropies of landscape gradients and mosaics that can now been computed.
Objectives: This study aims to investigate the energy (information) flow from landscape gradients to mosaics. The first objective is to verify the feasibility of applying thermodynamic entropy to characterize the thermodynamic features of both landscape gradients and mosaics. The second objective is to generalize the first law of thermodynamics to model energy flow with thermodynamic entropy.
Methods: A kinetic-theory-based approach is employed to examine the usability of thermodynamic entropy to landscape modelling. The Jarzynski equation for the first law of thermodynamics is generalized to model the energy flow from landscape gradients to mosaics with thermodynamic entropy. Hypothesis-driven experiments were carried out to verify the generalized Jarzynski equation.
Results: The usability of thermodynamic entropy to describe the thermodynamic features of multispectral remotely sensed imagery (landscape gradients) and land use and land cover patterns (landscape mosaics) is substantiated. Upon such entropy, a generalized Jarzynski equation is formulated to describe the energy transformation from landscape gradients into mosaics, which takes a form of linear relationship between the free energy (information) change of landscape models and valid work by classifiers.
Conclusions: The energy flow from landscape gradients to mosaics is consistent with the first law of thermodynamics and can be expressed by a linear model expressing the relationship between thermodynamic entropy change of landscape models and valid work by classifiers. This study provides a case for linking thermodynamic laws and concepts with the characterization and understanding of heterogeneity of landscape structure.
Huangtu decoction alleviates chronic diarrhea of spleen-yang deficiency in mice by altering host metabolome and intestinal microbiota composition
Authors: chen wenwen , Huang Chunyan , Tang Dandan , Wan Jun , zhou xia , Wu Chunjie , yang xiao 
Published: December 2022

Abstract
Background: Huangtudecoction (HTD), a traditional Chinese medicine recipe, warms the spleen, nourishes the blood, and stops bleeding. It has been used to treat dysentery, gastrointestinal bleeding, diarrhea, and other symptoms caused by spleen-yang deficiency for more than 2,000 years in China. However, the mechanism underlying the treatment of chronic diarrhea due to spleen-yang deficiency (CDSD) using HTD remains unclear.
Aims: This study investigated whether HTD could mediate intestinal flora and serum metabolites to improve CDSD symptoms using a mouse model.
Methods: A CDSD mouse model induced by senna and an abnormal diet was constructed. The regulatory effects of HTD at 12.5, 25.0, and 50.0 g/kg/d on CDSD mice were assessed by measuring their bodyweight, diarrhea rate, loose stool rate, and histopathology. Changes inthe intestinal flora of CDSD mice were analyzed by 16S rRNA gene sequencing. Untargeted serum metabolomic analysis was performed using UHPLC-MS/MS.
Results: The results showed that HTD had a modulating effect on CDSD by reducing the weight loss, diarrhea rate, loose stool rate, and pathological damage. The intestinal flora analysis showed that HTD altered the community composition by decreasing the abundance of Allobaculum, Lactobacillus, and Ruminococcus. Serum metabolomics revealed that the ascorbate and aldarate metabolism, aldosterone synthesis and secretion, platelet activation, hypoxia-inducible factor 1 signaling pathway, inositol phosphate metabolism, phosphatidylinositol signaling, galactose metabolism, and alpha-linolenic acid metabolism were modulated after HTD treatment.
Conclusion: HTD may alleviate CDSD symptoms by reducing weight loss, diarrhea rate, loose stool rate, and pathological damage caused by modeling and regulating intestinal flora and serum metabolites in CDSD mice.
Distribution of volatile organic compounds around Ulsan Industrial Complexes and its possible health impact on the residents; a cross-sectional study
Authors: Kim A Ram , Bang Jin Hee , Oh Yeonsuh , Kim Yangho , Yoo Cheolin , Sim Changsun , Lee Jiho 
Published: December 2022

Abstract
Background

The Republic of Korea has undergone rapid industrialization, and still, the manufacturing sector mainly contributes to the economy. Ulsan is well known as the industrial city where two large-scale industrial complexes are located, and both have petrochemical and refining industries within them. Several studies have reported high ambient air pollution near petrochemical industries. Volatile organic compounds(VOCs) are one of the air pollutants emitted from the petrochemical industry known to pose adverse health effects on workers. However, studies on the impact of chronic exposure to low VOCs level are lacking. Therefore, this study aims to see the VOCs level near the industrial complexes and analyze the health impact.

Method

The Database based on the third phase of The Environmental Health Study in the Korean National Industrial Complexes (EHSNIC) in Ulsan conducted from 2018 to 2021 by the Environmental Health Center of Ulsan university hospital was used. Subjects were divided into the exposure and control group according to the estimated pollution level and distances from the industrial complex. Variables collected from the survey questionnaire, laboratory data, measurement data, and biological monitoring data were collected and analyzed. The VOCs levels and urinary metabolite levels were log-transformed before the statistical analysis.

Result

Among the total 1,234 subjects, 718 belonged to the exposure group, and 516 were in the control group. Benzene, ethylbenzene, and xylene were significantly higher in the exposure group. Urinary methyl hippuric acid, trans,trans-muconic acid, and mandelic acid were significantly higher in the exposure group compared to the control group, even after adjustment of the confounders.

Conclusion

We found out that residents living near the industrial complexes are exposed to higher VOCs levels, which is confirmed by the urinary metabolites concentration and personal monitoring VOC level. These results can draw attention to people engaged with environmental plans and used as primary data when making policies to reduce pollutant levels around industrial complexes.
Trial registration: IRB No. 2018-08-020
Effects of combined aerobic and resistance exercise on body composition and physical function in older adults: a systematic review
Authors: Meng Fanjing , Shu Dingbo , Chen Feng , Chen Yajiao , Wang Jianping , Liu Xiaochen , Wang Le , Xiao Xiangyue , Ding Jianping , Dai Siyu 
Published: December 2022

Abstract
Background and objective

The health impacts of combined aerobic and resistance training on older populations are largely unknown. Therefore, we carried out the current study to systematically investigate the effects of combined exercise on body composition and physical functions of elders.

Methodology

Literature was searched from PubMed, Embase, Cochrane, Web of Science and Google Scholar. Inclusion criteria were: 1) healthy participants aged 55 years and above; 2) effects of combined exercise (aerobic combined with resistance training) examined; 3) effects on fat mass and lean mass reported. Research quality of the included studies was assessed by PEDro scale.

Results

Among the involved 11 studies, 9 out of 11 found that combined exercise increased the amount of lean mass of the elders (0.3–7.4%), while the other 2 reported a decline (3.0% and 3.4%). As for fat mass, all the included studies found that combined exercise decreased the total fat mass (2.19–16.5%) or local fat mass (0.7–40.7%). Furthermore, 5 out of the 11 studies examined the impact of combined training on muscle strength and aerobic power, and exercise was found to increase the lower limb strength (knee flexion: 15.1–15.9%; knee extension: 11.6–16.9%; and leg press 1 RM: 17.6–54.3%). Moreover, 5 studies assessed and reported that combined exercise was associated with an increased VO2peak (1.0–145.6%).

Conclusions

This systematic review revealed that a 8–52 weeks’ combined exercise, such as cycling combined with weight-lifting machines training, was beneficial in a decrease in whole-body and localized fat mass, and increase in the amount of body lean mass among older populations. Combined exercise was also shown to be more effective in increasing lower extremity strength and VO2peak compared with aerobic or resistance ones solely.
An in silico approach for the identification of detrimental missense SNPs and their potential impacts on human CRY2 protein
Authors: Khan Auroni Semonti , Akter Mahmuda , Enni Mansura Akter , Khan Sumaiya Farah 
Published: December 2022

Abstract

CRY2 is one of the four central proteins of the cell-autonomous molecular clock in mammals. Numerous missense SNPs have been reported in the cry2 gene which results in missense variants of CRY2. These were correlated with diverse metabolic diseases as well as autism spectrum disorders. Thus, we performed in silico analysis of the human CRY2 (hCRY2) protein, assessing the structural stability and interaction of the protein with the FBXL3 and PER2. Multiple computational tools were used in each phase of the analysis assuring the reliability of the data. The computational study suggests that among 436 missense variants of hCRY2, variants: L74P, L274P, L309P, F315V and Y485H were the most destabilizing missense mutants. These variants were found to alter hCRY2 structure and FAD binding pocket that likely affects the binding of its cofactor FAD and interfering the binding mode of other CRY activating compounds. Structural alterations also reduce the binding affinity to regulatory proteins FBXL3 and PER2, which may cause imbalance in the circadian period length in cells as well as develop multiple abnormalities. These five missense variants warrant detailed in vitro and in vivo investigations to solidify their roles in damaging the protein structure, stability, interaction with protein partners.
WITHDRAWN: Mediating the Effects of Servant Leadership on Performance via Emotional and Intellectual Trust
Authors: Sevy John , Frank Terri , Henry Simon 
Published: December 2022

Abstract

In recent years, "servant leadership" has become increasingly popular as a management style for its emphasis on helping others succeed. It has been suggested in the literature that a more in-depth understanding of how servant leadership affects organizational performance would be beneficial. We investigate how trust in two dimensions—emotional and rational—serves as a mediator between servant leadership and employee productivity. We analyzed 233 pairs of employees and their superiors. Using a hierarchical linear model (HLM) for clustered data, we found that servant leadership was a robust predictor of subordinates' emotional trust, OCBs, and task performance. Furthermore, we found that subordinates' confidence in their leaders entirely mediated this relationship. The impact of servant leadership on OCB and task performance was not attenuated by the level of cognitive trust amongst team members. These results illustrate how affective trust acts as a mediator between servant leadership and improved behavior in the followers.
Prevalence, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
Authors: Wang Ling , Zeng Chaoying , Li Xue , Li Yuqing , Liu Zhihua , Hu Jing 
Published: December 2022

Abstract
Background
The long-term epidemiological surveillance of carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection (BSI) is limited in China, and the impact of carbapenem resistance on mortality remains unknown. This study aimed to investigate the prevalence, factors and outcomes of CRKP BSI, and examine the attributable mortality of carbapenem resistance.
Methods
This retrospective study enrolled 87 patients with CRKP BSI and 321 patients with carbapenem-susceptible Klebsiella pneumoniae (CSKP) BSI from 2015 to 2020. Multivariate logistic regression was performed to identify risk factors for infection and mortality. Stabilized inverse probability of treatment weighting was applied to balance covariates. Cox regression and Kaplan-Meier curves were used to estimate the attributable mortality of carbapenem resistance.
Results
An alarming increasing trend of CRKP BSI was observed during the six years. Longer hospitalization stay, intensive care unit stay, blood purification and antibiotic exposure were risk factors for CRKP BSI, whereas primary BSI and underlying diabetes were factors for CSKP BSI. The crude 30-day mortality of CRKP BSI was independently associated with age ≥ 55 years, underlying hematological malignancies and blood purification, while the infection source from skin and soft tissue, urinary catheter and underlying chronic obstructive pulmonary disease were predictors for CSKP BSI. The hazard ratios reflecting the impact of carbapenem resistance on 30-day mortality was 1.586 (0.791–3.182).
Conclusions
The 30-day mortality was not attributed to carbapenem resistance in KP BSI. Infection control policies for severely ill patients with prolonged hospitalizations and intensive care and patients with blood purification should be strengthened for CRKP BSI management.
Effect of precursor molecular structure on the facile synthesis of efficient red-emissive two-photon carbon dots: real-time cellular imaging and high-resolution deep-tissue imaging
Authors: Lesani Pooria , Hadi Aina Hazeera Mohamad , Khetarpaul Mansi , Lu Zufu , Zreiqat Hala 
Published: December 2022

Abstract
In recent years, the development of carbon dot-based fluorescent nanoparticles for bioimaging applications has attracted the attention of scientific community. However, the functionality of the majority of these developed fluorescent systems is confined in to the blue-to-green region of the light spectrum, limiting their application as bioimaging agents. Here, we report the facile design and development of highly efficient two-photon excitable red-emissive carbon dots (D-CD) and demonstrate their high performance in bioimaging applications. Our comprehensive study on the effects of synthesis parameters on the photophysical and physicochemical properties of carbon dots demonstrated the importance of precursor selection and consideration of its molecular structure in developing red-emissive carbon dots. The developed D-CD is highly biocompatible and non-toxic, with remarkable photostability in cells under two-photon near-infrared excitation. The present study point to the great potential of D-CD as an efficient bioimaging agent for cellular biolabeling, long-term and real-time cellular imaging, and high-resolution deep-tissue imaging in complex biological systems.