bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sonic hedgehog N-terminal level correlates with adiponectin level and insulin resistance in adolescents
Authors: Takaya Junji , Tanabe Yuko , Kaneko Kazunari 
Published: December 2022

Abstract

Objectives
Extracellular vesicles (EVs) are small vesicles released by nearly all types of cells. They deliver different types of substances, including proteins and nucleic acids, to nearby or distant cells and play a role in the mediation of cell-to-cell communication. The aim of this study was to explore the association between EVs and insulin resistance in adolescents with obesity or type 2 diabetes mellitus (DM2).

Methods
The subjects were eight adolescents with DM2 (DM2 group; four males and four females; age: 18.1 ± 2.3 years), 18 adolescents with simple obesity (obesity group; 12 males and six females; age: 12.2 ± 3.4 years), and 20 controls (control group; 10 males and 10 females; age: 13.0 ± 1.4 years). As markers of EVs, serum CD9/CD63 and sonic hedgehog N-terminal (Shh-N) levels were measured using enzyme-linked immunosorbent assay.

Results
The CD9/CD63 level in the control group was similar to that in the DM2 group, whereas the obesity group had a significantly higher CD9/CD63 level. In the entire study group, correlations were observed between serum Shh-N level and Homeostasis Model Assessment of insulin resistance (HOMA-IR) score (r=0.371, p=0.0143), Homeostasis Model Assessment-β cell function score (r=0.382, p=0.0115), serum insulin level (r=0.350, p=0.0171), and serum adiponectin level (r=0.367, p=0.0122). Multiple regression analysis revealed that serum Shh-N level was the most significant risk factor for HOMA-IR score and serum insulin level.

Conclusions
Shh is correlated with insulin resistance via its association with adiponectin in adolescents.
Phrasal subcomparatives: a comparative coordination analysis based on evidence from Basque, Spanish, and English
Authors: Vela-Plo Laura 
Published: January 2023

AbstractBy analyzing an understudied type of comparative, namely, subcomparatives with surface-phrasal standards of comparison, this article offers an answer to three long-debated questions regarding the internal structure and semantic composition of comparative constructions in opposition to traditional assumptions and reductionist analyses. First I offer syntactic tests evidencing the non-clausal status of the standard in these subcomparatives in Basque, Spanish and English. Second, regarding the question of the linkage type between the compared elements (either a dependence relation or a coordination relation), I present previous and novel syntactic evidence showing that phrasal subcomparatives invariably behave like common phrasal coordinates. Therefore, I defend an architecture of these comparatives involving a phrasal coordinate structure and offer a transparent mapping between the surface syntax and semantic interpretation of these constructions. Third, subcomparatives involve the obligatory omission of a measure modifier from the standard. This process known ascomparative subdeletioncannot be explained as the result ofwh-movement within a clause, given the non-clausal status of the standard. Alternatively, comparative subdeletion is defined not as anad hocdeletion rule but rather as the result of an obligatory deletion operation independently attested in common coordinate structures.
Study on r-truncated degenerate Stirling numbers of the second kind
Authors: Kim Taekyun , Kim Dae San , Kim Hyekyung 
Published: January 2023

Abstract
The degenerate Stirling numbers of the second kind and of the first kind, which are, respectively, degenerate versions of the Stirling numbers of the second kind and of the first kind, appear frequently when we study various degenerate versions of some special numbers and polynomials. The aim of this article is to consider the r-truncated degenerate Stirling numbers of the second kind, which reduce to the degenerate Stirling numbers of the second for r = 1, and to investigate their explicit expressions, some properties and related identities, in connection with several other degenerate special numbers and polynomials.
Synthesis of PEITC-loaded gold nanoparticles and evaluation of the hepatoprotective effect on CCl4-induced damage through Nrf2 pathway
Authors: Uyumlu Ayşe Burçin , Çağlar Yılmaz Hatice , Satılmış Basri , Erdemoğlu Sema 
Published: January 2023

Abstract

Objectives
The purpose of the study was to prepare an effective and new drug delivery system for enhancing the stability of Phenethyl isothiocyanate (PEITC), and its hepatoprotective effect in the carbon tetrachloride (CCl4)-induced damage in hepatocellular carcinoma G2 (HepG2) cell line via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.

Methods
Gold nanoparticles were synthesized and then characterized by XRD, SEM, SEM-EDX analysis, hydrodynamic diameter and zeta potential measurements. 1.0024 mM PEITC, a naturally occurring isothiocyanate, an active ingredient was loaded onto the characterized AuNPs. The cytotoxicity test of PEITC-AuNP and effects on ALT, AST, Nrf2 levels and total antioxidant capacity (TAC) of CCI4-induced HepG2 cells were investigated.

Results
PEITC-AuNPs and PEITC decreased ALT and AST levels (p<0.05). This reduction was greater with PEITC-AuNPs. PEITC-AuNPs increased Nrf2 level but it was nonsignificantly (p>0.05). PEITC didn’t increase the Nrf2 level in CCI4-induced HepG2 cells. TAC of both PEITC-AuNPs and PEITC administration increased significantly compared with CCl4 group (p<0.05). But PEITC-AuNPs enhanced the TAC level higher than PEITC significantly (p<0.05).

Conclusions
PEITC-AuNPs were more effective than PEITC which resulted in more hepatoprotective and antioxidant effects via Nrf2 activation against CCl4-induced liver injury in HepG2 cells.
A relevância da Infraestrutura Verde na paisagem urbana: uma contribuição aos serviços ecossistêmicos
Authors: Fruehauf Amanda Lombardo , Chiarotto Aline Beatriz Seriani , Silva Pollyane Vieira da , Minks Volker 
Published: December 2022

Em centros urbanos, a falta de planejamento proporciona um crescimento desordenado dos espaços urbanos. O objetivo desta revisão é fazer uma análise bibliométrica, utilizando três bases de busca Scielo, Scopus e Web of Science, de estudos que demonstrem a contribuição da Infraestrutura Verde no clima urbano, qualidade de vida, paisagem urbana e biodiversidade, a fim de elucidar o modo com que a Infraestrutura Verde é abordada em trabalhos científicos. Para melhor visualização dos dados, utilizou-se da ferramenta estatística por meio da análise exploratória dos dados obtidos pelo levantamento bibliográfico sobre o tema, realizada pelo software R, no ano de 2021. Na revisão sistemática, foram realizadas as buscas de artigos científicos sobre a Infraestrutura Verde e sua influência na paisagem urbana nas seguintes bases de dados: Scopus, Scielo e Web of Science, onde estes apresentaram respectivamente: 61, 18 e 87 artigos. A base de dados onde se encontram mais artigos foi a Web of Science, com 52,4%, seguido do Scopus com 36,7% e Scielo com 10,8 %. Destaca-se que nas três bases de dados analisados, nos últimos oito anos (de 2013 a 2021), o número de publicações sobre a Infraestrutura Verde é crescente. A maioria dos trabalhos publicados se concentra em cidades da Europa e dos Estados Unidos. Assim, verifica-se a partir da análise bibliométrica com auxílio da estatística a ocorrência de estudos da Infraestrutura Verde nos anos e nos países, nas bases de dados, sendo um tema importante para solucionar dimensões sociais, econômicas e ecológicas.
PALAVRAS-CHAVE: Clima urbano. Qualidade de vida. Biodiversidade.
COVID 19 Outbreak and Tokyo 2020 Olympic Games: A Perspective from Japan’s Economy and Capital Market
Authors: Annathurai Anusha 
Published: December 2022

This study highlights the key impacts of hosting an international sports event, Tokyo 2020 Olympic Games, during the period of deadliest contagious disease outbreak in history, COVID 19. The perspective is analysed in terms of the performance of capital market, investment market and sectoral market by the indexes of TOPIX, Stock Market, Bond Market, Foreign Exchange, FTSE, MSCI, and sectoral index of Air Transportation, Construction, Pharmaceutical which shows different range of fluctuation.
Power Management Strategies in Energy-Harvesting Wireless Sensor Networks
Authors: El Abdellaoui Said , Fakhri Youssef 
Published: December 2022

Power management strategies are extremely important in Wireless Sensor Networks (WSNs). The objective is to make the nodes operate as long as possible. In the same context, in this article, our aim is to provide the optimal transmission power to maximize the network lifetime using the Orthogonal Multiple Access Channel (OMAC) in Harvesting System (HS). We consider that the nodes have direct communication with a Fusion Center (FC) with causal Channel Side Information (CSI) at the sender and receiver.We begin the analysis by considering a single transmitter node powered by a rechargeable battery with limited capacity energy. Afterward, we generalize the analysis with M transmitter nodes. In both cases, the transmitters are able to harvest energy from nature.Eventually, we show the viability of our approach in simulations results.
Modeling, Development and Analysis Performance of an Intelligent Control of Photovoltaic System by Fuzzy Logic approach for Maximum Power Point Tracking
Authors: Barakate Ahmed Amine , Abdelmoumene Rida , WAHBI Azeddine , Maddi Mohamed , Hlou Laamari , Hadjoudja Abdelkader 
Published: December 2022

In this paper, we present an intelligent algorithm based upon Fuzzy Logic method for optimizing and improving the control performance of a photovoltaic system. The main objective of the proposed system is to pursuit the maximum power point (MPPT) under different conditions like the change of sunshine and temperature. The system consists of a photovoltaic solar module connected to a DC-DC step-up converter "Boost" and a battery - like a load . The converter parameters and the inference rule table are determined to ensure maximum output power. The effectiveness of the proposed system is validated through computer simulations using MATLAB / Simulink software and the obtained results shows that our proposed system has the best performance in term maximum power.
Octreotide Lar in Patients with Autosomal Dominant Polycystic Kidney Disease: From Bench to A Novel Perspective of Therapy
Authors: Ruggenenti Piero , Perna Annalisa , Caroli Anna , Perico Norberto , Trillini Mattias , Pisani Antonio , Spinelli Letizia , Remuzzi Giuseppe 
Published: January 2023

Polycystins 1 or 2 congenital defects result in impaired Ca2+ inflow through the tubular cell membrane with reduced intracellular Ca2+ concentration and secondary adenylcyclase over-activation with increased intracellular cAMP. This activates chloride-driven fluid secretion and tubular cell proliferation and de-differentiation with cyst formation and growth. Thus, medications, such as the somatostatin analogue Octreotide LAR or the vasopressin antagonist Tolvaptan, that reduce intracellular cAMP, have been tested to inhibit cAMP-mediated chloride secretion and cell proliferation in experimental and human polycystic kidney disease. Seminal studies conducted in the early ‘80s by Franklin Epstein showed that in the shark rectal gland chloride secretion is markedly inhibited by somatostatin in a way suggesting inhibition of adenylcyclase. Evidence that specific receptors for somatostatin, in particular the sst2 subtype, are present in tubular cell membranes suggested that Octreotide LAR binding to its specific renal receptors could exert similar effects in ADPKD cells. In a pilot, cross-over safety study we found that 6-month Octreotide LAR therapy was safe and well tolerated in 12 patients with ADPKD and significantly decreased total kidney volume growth as compared to placebo. Then, the ALADIN and ALADIN II academic, prospective, randomized, placebo-controlled clinical trials found that 3-year Octreotide LAR treatment significantly slowed total kidney and cyst volume growth. In ALADIN treatment slowed chronic decline of directly measured GFR in 79 patients with estimated GFR ≥ 40 ml/min/1.73 m2. In ALADIN II treatment slowed progression to doubling of serum creatinine or ESKD in 100 patients with stage 3b-4 CKD. Treatment was equally safe and well tolerated in both studies. Sub-studies also showed that 3-year Octreotide LAR therapy reduced total liver volume in 27 ADPKD patients with associated polycystic livers and improved left ventricular twisting and untwisting function in 34 ADPKD patients assessed by speckled-tracked echocardiography. Future trials should confirm the long-term benefits of Octreotide LAR in larger populations of ADPKD patients. Moreover, recent studies found that somatostatin analogues and Tolvaptan have additional beneficial effects in experimental polycystic kidney disease. Thus, clinical trials should also explore whether Octreotide LAR and Tolvaptan in combined therapy may have an additional beneficial effect even in human disease.
Relationship between autoantibodies against type 2 deiodinase and antithyroid autoantibodies in Graves’ disease using antithyroid drug therapy
Authors: Molnár Ildikó 
Published: January 2023

Background: Previously, the presence of autoantibodies against type 2 deiodinase cys- and hom-peptides was investigated in Graves’ disease with relation to thyroid function, ophthalmopathy and therapy. The new design was to reveal the relationship among antithyroid antibodies involved in hormone synthesis. Aim and scope: To demonstrate some regularity between the appearance of peptide autoantibodies and antithyroid antibodies against TSH receptor, thyroid peroxidase and thyroglobulin, the study followed the main path of hormone synthesis and the effect of antithyroid drug treatment. Has any effect of peptide autoantibodies on the titers of other autoantibodies? Methods: The methods were described in our previous papers detailed. Autoantibodies against type 2 deiodinase peptides were detected with enzyme-linked immunosorbent assay in 78 patients with Graves’ disease and 30 controls. Thyroid hormones (TSH, FT4 and FT3) and antibodies against TSH receptor, thyroid peroxidase and thyroglobulin were measured with chemiluminescence immunoassay. Results: The frequency of cys-peptide antibodies was greater in the new onset of Graves’ disease. Propylthiouracil treatment was associated with increased occurrence of cys-peptide antibodies (p<0.0069). No dose-dependency in methimazole treatment could be demonstrated for cys-peptide antibody levels. Antibodies against hom-peptide or both peptides demonstrated a strong relationship with the appearance of antithyroid antibodies. No peptide antibodies were associated with anti-thyroglobulin antibody positivity (0 cases out of 11 for hom-peptide, p<0.0071 and 0 cases out of 8 for both peptides, p<0.0251). In contrast, all cases with TSH receptor antibody positivity were positive for peptide antibodies (all cases out of 13 for hom-peptide, p<0.0139 and all cases out of 9 for both peptides, p<0.0470). TSH receptor antibody levels were relevantly decreased, when hom-peptide antibodies were present [24.35(15.68-37.8) vs 11.8(8.16-17.07) IU/l, p<0.0437]. Conclusion: The presence of hom-peptide antibodies was connected to the absence of antibodies against thyroglobulin and smaller anti-thyroid peroxidase antibody positivity. The presence and the high titers of TSH receptor antibodies demonstrated a close relationship with the appearance of hom-peptide antibodies. The relationship among the studied autoantibodies may depend on the alteration of thyroid hormone synthesis and the steric hindrance of targets and antithyroid drug treatment. Autoantibodies against type 2 deiodinase peptides can influence the therapeutical effectiveness
Pincer Maneuver: Legality of China’s Economic Measures towards India
Authors: Gemilang Adinda Balqis Tegarmas 
Published: January 2023

China today has an enormously massive and diverse industrial sector which cemented its role as the world’s factory. This status is mainly borne from cheap, plentiful and capable workforce that given by the size of its population. Increasingly belligerent stances taken by the Chinese Communist Party (CCP) in combination with myriad of other factors have led industries to slowly move their production elsewhere. The alternative, in form of China’s nemesis, India which has started to woo manufacturer to do business with them as a more competitive and open market in combination with the abundance of cheap and capable workforce. China in realizing this move are now exposed to the existential problem of power. With the wealth accumulated, China has started curbing the effect of the relocation of its manufacturing sectors to India. Initiatives and program that they create have strangely unaffected India in its efforts to enter into the global manufacturing and distribution system. The paper aims at answering the question on the legality of China’s economic measures toward India from the perspective of the existing international law. This normative legal research relies on primary and secondary sources. The study found that the mentioned economic measures are in line with the applicable international law.
Evaluation of MMP-9 with atherogenic index and electrocardiogram as a predictor of cardiovascular risk factors in hypertensive patients
Authors: Gupta Gaurav , Jain Richa , Das Biswajit , Saxena Shikha 
Published: December 2022

Hypertension is the strongest or one of the strongest risk factors for almost all different cardiovascular diseases acquired during life, including coronary disease, left ventricular hypertrophy, and valvular heart diseases. So, the aim of this study was to evaluate the plasma concentration of MMP-9 and AIP in mild to moderate hypertensive patients. : A total of 162 patients with hypertensive case were recruited and compared with the 100 normotensive controls from the Rohilkhand Medical College and Hospital Bareilly. Parameters include waist circumference (WC), Fasting Blood Sugar (FBS), Lipid profile with Atherogenic Index, and Matrix metalloproteinase-2 were estimated in the plasma of all the test groups. Electrocardiography (ECG) was also performed as a cardiovascular tool.There was a significantly increased concentration of WC, FBS, and Lipid parameters except for HDL which is slightly lower in the case group when compared to the control group. The concentration of MMP-9 was also increased, which is positively significant. The mean value of the P-R interval, QRS complex, and QT interval was also increased in hypertensive as compared to the controls.Atherogenic index and MMP-9 are significantly higher in hypertensive patients. So, it could be a biomarker of cardiovascular disease.
Diagnostic role of different biochemical parameters in pleural effusion
Authors: Singh Jaspreet , Singh Khushdeep , Saini Rincal , Kumar Umesh , Sharma Shiv , Singh Harvinder 
Published: December 2022

A pleural effusion, an excessive accumulation of fluid in the pleural space, indicates an imbalance between pleural fluid formation and removal. For diagnosing and treatment plan, pleural effusions have to be classified into transudate and exudate. The aim of present study was to analyze various biochemical parameters (LDH, pH, Glucose, Triglycerides, Cholesterol, Creatinine, Amylase and ADA) in pleural fluid and to correlate these Biochemical parameters with diagnosis of the patients. The study was a hospital based descriptive study. The study was conducted over a period of one year on 100 samples. Total 100 samples were enrolled in the study. Both serum and pleural fluid samples were collected and quantitatively analyzed using semi-automated analyzer. The results of the present study shows thatThe Mean±SD of concentration of glucose in pleural fluid was 65.69±14.13 mg/dl, total protein 3.53±1.53g/dl, albumin 1.64±0.85g/dl, cholesterol 58.9±13.05mg/dl, triglycerides 68.7±10.47mg/dl, creatinine 1.73±0.96mg/dl, amylase 49.56±17.78IU/L, LDH 299.82±65.46 U/L and ADA was 49.56±17.78U/L.It was concluded that Biochemical parameters play important role in diagnosing Pleural effusions. These markers when used collectively their diagnostic efficacy is greatly increased. The SEAG is superior to Light's criteria in identifying the transudative effusions. It is also observed that Light's criteria identified exudative effusions better than SEAG.
Correlation between cephalic index and facial index in skeletal malocclusions – An analytical cross-sectional study
Authors: Antony Vincy , Prachodh C A  , Shaloob Muhamed , Parayaruthottam Prathapan , Nayaz Mohamed , Raheesh Muhammed 
Published: January 2023

: The study aimed to assess the correlation between Cephalic Index and Facial Index in patients with skeletal malocclusions reporting to the Department of Orthodontics and Dentofacial Orthopedics in a private Dental College in Kerala.: A study was conducted using analytical cross-sectional study design, on patients numbering 120 (40 Class I, 40 Class II & 40 Class III) between ages 18 to 30 years. Statistical analysis was carried out with SPSS version 22.0 (SPSS Inc., Chicago, IL). The data was assessed using the Shapiro-Wilk test for normality. Inferential statistics to find the difference between the Cephalic and Facial Indices was done using the independent t-test and Chi-square test for proportion analysis. Correlation coefficient between the Facial and Cephalic indices was assessed using Pearson Correlation Coefficient.: A weak negative correlation existed between the Cephalic Index and Facial Index in different skeletal malocclusions - (-0.28) in Class I, (-0.15) in Class II and (-0.08) in Class III malocclusion.: The present study observed that cranial morphology exerted a weak morphologic influence on the facial type as indicated by the weak negative correlation between the Cephalic Index and Facial Index in the different antero-posterior malocclusions.
O USO DO INSTAGRAM COMO FERRAMENTA PARA CONQUISTAR CLIENTES: UM ESTUDO NAS LOJAS DE VESTUÁRIO EM LAGOA DE SÃO FRANCISCO – PI
Authors: Sousa Maria Natália De Oliveira , Chaves Márcia Dos Santos , Feitosa Aryadynna Dos Santos 
Published: December 2022

<p>A internet hoje é vista como um excelente canal para atrair e conquistar clientes. A temática que se apresenta neste trabalho está relacionada ao seguinte questionamento: Qual a importância da rede social Instagram para as lojas de vestuário no município de Lagoa de São Francisco-PI e o impacto no relacionamento com o cliente? O objetivo geral é analisar a contribuição do Instagram para o relacionamento com os clientes das lojas pesquisadas. Em caráter de objetivos específicos, busca-se identificar como o Instagram é utilizado pelas lojas em estudo, verificar as formas de interação com o público atingido e compreender de que forma as ferramentas oferecidas pela rede social são úteis para o negócio. Tratou-se de uma pesquisa bibliográfica, através de livros, artigos, sites, para o embasamento teórico e, para atingir os objetivos propostos, realizou-se uma pesquisa de campo por meio do envio de questionário aos proprietários/gestores das lojas de vestuário situadas na zona urbana de Lagoa de São Francisco-PI. Como resultado observou-se que a maioria das lojas utiliza o Instagram, seus gestores o consideram importante para o negócio, pois com uso dessa rede social foi possível tornar a loja mais conhecida, melhorar o relacionamento com o público-alvo e conquistar novos clientes. A contribuição da pesquisa consiste em um melhor entendimento acerca da relevância do uso do Instagram pelas empresas e o impacto no relacionamento com o cliente. Este trabalho contribuirá no âmbito acadêmico, servindo como base para futuros estudos e incentivando a realização de novos projetos voltados para a temática.</p><p> </p><p>Palavras-chave: Rede Social Instagram; Relacionamento com cliente; Empresa.</p>