bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spezialisierte Physiotherapie bei funktionellen Bewegungsstörungen
Authors: Degen-Plöger Christof , Reincke Annemarie , Fasching Bernhard , Lüdtke Kerstin 
Published: August 2023

ZUSAMMENFASSUNGDie Physiotherapie bei funktionellen Bewegungsstörungen unterscheidet sich erheblich von einer konventionellen neurologisch ausgerichteten Physiotherapie. Sie folgt einem kognitiv-verhaltenstherapeutischem Ansatz, im Sinne einer psychologisch informierten Physiotherapie. Dabei werden multiple Faktoren in den Therapieprozess mit einbezogen, welche anhand des bio-psycho-sozialen Modells erhoben werden, um die hintergründigen Symptomtrigger und -modulatoren zu eruieren. Sie zielt darauf ab, dass der betroffene Patient das Krankheitsbild versteht und akzeptiert sowie den Therapieinhalten Bedeutung beimessen kann. Das Erarbeiten einer bewussten Aufmerksamkeitslenkung (Strategie), weg von der eigentlichen funktionellen Störung, ist ein zentraler Bestandteil. Diese erfolgt über die Nutzung unserer Sinnesreize, Verlagerung des Fokus auf intakte Bewegungsmuster, zielorientierten Handlungen sowie dem Einsatz einer bewussten Sprache. Das Selbstmanagement im Umgang mit beeinflussenden Faktoren, der Aufbau einer Toleranz gegenüber solchen und ein allgemein gesundheitsförderndes Verhalten runden die Therapie ab. Im vorliegenden Artikel stellen wir diesen Therapieansatz, welcher in Deutschland erstmalig im ambulanten Setting innerhalb einer Studie erprobt wird, vor und geben Empfehlungen für die Praxis.
Multimodale Therapie funktioneller Bewegungsstörungen im stationären Setting
Authors: Schmidt Tamara , Ebersbach Georg 
Published: August 2023

ZUSAMMENFASSUNGDie multimodale, stationäre Therapie funktioneller Bewegungsstörungen ist eine kaum etablierte Aufgabe für neurologische Kliniken. Besondere Herausforderungen ergeben sich aus den strukturellen Voraussetzungen (multimodales Therapieangebot mit entsprechender fachlicher Expertise) und den teils langwierigen und komplexen therapeutischen Prozessen. In diesem Beitrag wird ein in Beelitz-Heilstätten entwickeltes und seit Jahren klinisch erprobtes Behandlungskonzept exemplarisch dargestellt. Die Vergütung innerhalb des DRG-Systems und Indikationskriterien für eine Behandlung von funktionellen Bewegungsstörungen im stationären neurologischen Setting werden erläutert.
Müde Mitochondrien
Authors: Feldhaus Simon 
Published: August 2023

SummaryAnhand des vorliegenden Fallbeispiels veranschaulicht der Autor, wie bestimmte Virusinfektionen ein – häufig fehldiagnostiziertes – postvirales Fatigue-Syndrom nach sich ziehen können. Zu den Kardinalsymptomen gehören körperliche und geistige Erschöpfung und gesteigerte Ermüdbarkeit, begleitet von unter anderem Muskelschmerzen, Gedächtnis- sowie anderen kognitiven Störungen. Eine häufige Ursache ist eine Mitochondriopathie. Sie kann nach einer Funktionstestung der Mitochondrien individuell und kausal mit orthomolekularer Medizin behandelt werden.
Der Nationale Kompetenzbasierte Lernzielkatalog 2.0 für das
Fach „Physikalische und Rehabilitative Medizin,
Naturheilverfahren“. Konsentierte Ergebnisse beteiligter
Fachgesellschaften der AWMF.
Authors: Mau Wilfried , Bethge Matthias , Liebl Max Emanuel 
Published: August 2023

Zusammenfassung
Hintergrund Im Rahmen der Weiterentwicklung des Nationalen
Kompetenzbasierten Lernzielkatalogs (NKLM) zur Version 2.0 erfolgte auch eine
Überarbeitung der Lernziele im bisherigen Querschnittsfach
„Rehabilitation, Physikalische Medizin, Naturheilverfahren“. Da
der NKLM grundsätzlich fächerübergreifend angelegt ist,
von verschiedenen Seiten aber eine Fächerzuordnung notwendig schien,
initiierten die Arbeitsgemeinschaft wissenschaftlich-medizinischer
Fachgesellschaften (AWMF) und der Medizinische Fakultätentag einen
Fächerzuordnungsprozess. Der Zuordnungsprozess für das Fach
„Physikalische und Rehabilitative Medizin, Naturheilverfahren“
(PRM-NHV; laut Fächerliste des ersten Referentenentwurfes der geplanten
Approbationsordnung aus dem Jahr 2020) wird in dieser Arbeit dargestellt.
Materialien und Methoden Die AWMF lud ihre Mitgliedsgesellschaften ein,
sich an der Zuordnung von Lernzielen der Kapitel VI, VII und VIII des NKLM 2.0
zu den einzelnen Fächern zu beteiligen, zu denen sie nach eigener
Einschätzung einen Beitrag in der Lehre leisten. Für
„PRM-NHV“ beteiligten sich Vertreter*innen der DGRW,
DGPRM, DGOU sowie der DGNHK. In einem strukturierten Konsensprozess nach der
DELPHI-Methodik erfolgten Auswahl und Konsentierung der Lernziele.
Anschließend erfolgte durch die AWMF eine Fächerempfehlung.
Ergebnisse Aus dem NKLM 2.0 wurden insgesamt 100 kompetenzbasierte
Lernziele der Kapitel VII und VIII für das Fach
„PRM-NHV“ von den Vertreter*innen der beteiligten
Fachgesellschaften zur Darstellung auf der NKLM 2.0-Online-Plattform
konsentiert.
Schlussfolgerungen Im Rahmen des grundlegend geplanten Reformprozesses des
Medizinstudiums und unter dem Dach der AWMF und des Medizinischen
Fakultätentags gelang die breite Konsentierung von Lernzielen des NKLM
2.0 für die kompetenzbasierte Lehre im Fach „PRM-NHV“
durch die beteiligten Fachgesellschaften. Damit wird eine für alle
medizinischen Fakultäten wichtige Orientierung sowohl für die
Weiterentwicklung der Lehre im Querschnittsbereich „Rehabilitation,
Physikalische Medizin, Naturheilverfahren“ gemäß der
seit zwanzig Jahren gültigen 9. Revision der ÄApprO als auch
für die Vorbereitung der entsprechenden Fächer im
Referentenentwurf der neuen ÄApprO gegeben.
Pd-Catalyzed Remote δ-C(sp2)–H Functionalization in Phenylalaninol: Expanding the Library of Phenylalaninols
Authors: Babu Srinivasarao Arulananda , Singh Prabhakar 
Published: August 2023

AbstractWe report the Pd(II)-catalyzed, picolinamide-directed δ-C(sp2)–H (ortho) functionalization of phenylalaninol scaffolds. Assembling of (ortho) δ-C–H arylated, alkylated, benzylated, alkenylated, brominated, and iodinated phenylalaninol scaffolds was accomplished. The δ-C(sp2)–H arylation reaction of phenylalaninol occurred under neat conditions. Hydrolysis of the picolinamide moiety and synthetic utility of the δ-C(sp2)–H arylated substrates were explored. We have also shown the preparation of some modified Matijin–Su (aurantiamide) derivatives using the bis δ-C–H (ortho) arylated phenylalaninol compounds obtained from the δ-C(sp2)–H arylation reaction (Matijin–Su is an anti-HBV agent possessing the phenylalaninol unit). Considering the importance of phenylalaninols, this work contributes to expanding the phenylalaninol library and demonstrates the substrate scope development in remote δ-C(sp2)–H functionalization reactions.
The Reconstructive Toolbox
Authors: Hallock Geoffrey G. 
Published: August 2023

AbstractHistorically, the approach to any reconstructive challenge, whether intentionally or intuitively, can be seen to follow distinct guidelines that could aptly be called “reconstructive metaphors.” These have been intended to inform us as to the “what, “when” and “where” this attempt can best be achieved. Yet the “how” or means to accomplish this goal, usually also intuitively well understood, in a similar vein can now be expressed to be within our “reconstructive toolbox.” The latter will distinctly mirror our individuality and contain not only the various hardware that we deem essential, but also the means to access whatever technology we may be comfortable with. No toolbox, even if overflowing will ever be full, as potential options and the diversity they represent surely approaches infinity. But the truly excellent reconstructive surgeon will know when their toolbox is in any way lacking, and fears not remedying that deficiency even if the talents of another colleague must be sought, so as always to ensure that the patient will obtain the best appropriate treatment!
The Influence of Corticosteroid Injections on Postoperative Outcomes of Carpal Tunnel Release: A Systematic Review
Authors: Kumaş Ali , Warenburg Milly van de , Natroshvili Tinatin , Kemler Marius , Foumani Mahyar 
Published: August 2023

Abstract
Background Carpal tunnel syndrome can be treated with corticosteroid injections (CIs) and surgery. In this systematic review, the influence of previous CI on different postoperative outcomes after carpal tunnel release is evaluated.
Methods A systematic literature search using several databases was performed to include studies that examined patients diagnosed with carpal tunnel syndrome who received preoperative or intraoperative CIs.
Results Of 2,459 articles, 9 were eligible for inclusion. Four papers reported outcomes of preoperative and four outcomes of intraoperative CIs. One study evaluated patients who received both intraoperative and preoperative corticosteroids.
Conclusion Intraoperative CIs are associated with reduced postoperative pain after carpal tunnel release and support earlier recovery of the hand function that can be objectified in a faster median nerve conduction speed recovery and lower Boston Carpal Tunnel Questionnaire (BCTQ) scores. Using preoperative CIs did not lead to enhanced recovery after carpal tunnel release, and both preoperative and intraoperative CIs might be predisposing factors for infections.
Hyaluronic Acid Filler Injection Guided by Doppler Ultrasound
Authors: Lee Won 
Published: August 2023

AbstractDoppler ultrasound can be used to detect almost all arteries of the face before injecting the hyaluronic acid (HA) filler. The relatively more dangerous sites of filler injection are the glabellar wrinkle, forehead, temple, nose, and nasolabial fold area, and it is recommended to map the vasculature of these areas by Doppler ultrasound before performing filler injection. The Doppler ultrasound detection method is included as a video. Internal carotid arterial branches, the supratrochlear, supraorbital, and dorsal nasal arteries, and external carotid arterial branches, the superficial temporal and facial arteries, are very important arteries when injecting HA filler; thus, Doppler ultrasound detection is recommended.
Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing
Authors: Oh Mun Ho , Jang JaeHyuk , Lee Jong Hun 
Published: August 2023

Abstract
Background Macrophages play a major role in wound healing and prevent infection from the outside. Polarization conversion of macrophages regulates aspects of inflammation, and two macrophages, M1 (classically activated) and M2 (alternatively activated), exist at both ends of broad-spectrum macrophage polarization. Thus, we aimed to investigate whether macrophage polarization can be artificially regulated. To this end, MgSO4 and small-interfering RNA (siRNA) targeting magnesium transport 1 (MAGT1) were used to investigate the effects of intracellular magnesium (Mg2+) concentrations on the differentiation of macrophages in vitro.
Methods THP-1 derived macrophages maintained in a culture medium containing 5 mM MgSO4 and siRNA to inhibit the expression of MAGT1. As comparative groups, THP-1 derived macrophages polarized into M1 and M2 macrophages by treatment with M1, M2 inducer cytokine. The polarization status of each group of cells was confirmed by cell surface antigen expression and cytokine secretion.
Results We found that MgSO4 treatment increased CD163 and CD206, similar to the effect noted in the M2 group. The expression of CD80 and HLA-DR was increased in the group treated with MAGT1 siRNA, similar to the effect noted in the M1 group. Functional assays demonstrated that the group treated with MgSO4 secreted higher levels of IL-10, whereas the MAGT1 siRNA-treated group secreted higher levels of IL-6 cytokines. Additionally, the conditional medium of the Mg2+ treated group showed enhanced migration of keratinocytes and fibroblasts.
Conclusion Mg2+ can help to end the delay in wound healing caused by persistent inflammation in the early stages.
Review of Percutaneous Transesophageal Gastrostomy: A Multi-Hospital Academic Institution's Case Series of 24 Patients
Authors: Frenkel Joseph , Krausz Steven , Cynamon Jacob , Golowa Yosef , Hirschl David 
Published: August 2023

AbstractPercutaneous transesophageal gastrostomy (PTEG) is a minimally invasive technique involving percutaneous placement of an enteral tube via an esophagostomy in patients for whom conventional gastrostomy is contraindicated. We present a series of 24 patients who received PTEG, discuss indications for the procedure, and review outcomes. A retrospective chart review of the EMR was performed for patients who received PTEG from March 2016 through October 2021. Twenty-four patients were identified, and their records were reviewed for placement indication, technical success, adverse events, feeding complications, and replacement. Twenty-four patients (aged 29–91) required gastric tube placement for either enteral feeding or palliative venting. Conventional gastrostomy was contraindicated for reasons including difficult anatomy (eight), gastric surgery (five), malignancy (four), ascites (four), and wounds/infections (three). Technical success rate for placement was 100%. Minor postprocedural complications included local cellulitis, significant tube clogging, and dislodgement. There was one major complication, a significant bleed through the catheter entry site, which was successfully treated with a carotid covered stent. PTEG is safe and effective and should be strongly considered for gastric drainage or provisional supplemental nutrition in patients for whom percutaneous gastrostomy is contraindicated or technically not feasible.
Correlation between impulse magnitude and inhibition of cell proliferation in alternating electric fields therapy
Authors: Oh Geon , Jo Yunhui , Gi Yongha , Hong Jinyoung , Kim Jonghyun , Lee Boram , Yoon Myonggeun 
Published: August 2023

This study was designed to investigate the correlation between the impulse by dielectrophoretic force applied inside a dividing cell during alternating electric fields therapy and the inhibition of cell proliferation. Distributions of the electric field and dielectrophoretic force inside a dividing cell were calculated using the finite element method of COMSOL Multiphysics. Based on the results, the average magnitude of the impulse by the dielectrophoretic force applied to the cleavage furrow inside a dividing cell placed in various directions was calculated as a function of electric field intensity at an extracellular reference point. The simulation results showed that the average magnitude of the impulse to the cleavage furrow inside a dividing cell ranged from 1.51 × 10−9 to 1.49 × 10−7 N s when tumor treating fields with an intensity ranging from 0.1 to 1 V/cm is applied at an extracellular reference point for 6 h. To verify the relationships between the impulse by the dielectrophoretic force and the inhibition of cell proliferation, the survival fractions of the four cancer cell lines were determined as a function of intensity and time duration of the electric field. The correlation between the magnitude and application time of the electric field and the survival fractions of the four cell lines showed similar trends in vitro. These results suggest that both the dielectrophoretic force and the time required for the force to act are proportionally related to the inhibitory effect on dividing cells, enabling this impulse to be used as a reference to quantify the inhibition of cell proliferation.
Enhancement and localization of atomistic polarity and polarizability memory in light scattering upon hydrogenation of luminescent spherical 1 nm Si nanoparticles
Authors: Mantey Kevin , Rao Satish , Nayfeh Ammar , Palleschi Simonetta , Elhalawany Noha , Abuhassan Laila , Aldwayyan Abdullah S. , Alsalhi Mohamad , Nayfeh Munir H. 
Published: August 2023

The classical light interactions of nanosilicon, which is a dielectric material, are exceedingly weak for radius r ≪ λ (wavelength), scaling as r6. It exhibits geometrical anisotropy-based depolarization, which is the basis for the very weak response in isotropic structures (nanosphere). Recently, surface enhanced Raman scattering (SERS) in DNA decorated with ultrasmall Si nanoparticles has been demonstrated, affording an effective alternative to plasmon–metal particles. In this paper, we execute fundamental quantum atomistic computation of 1 nm hydrogenated Si particles, with different surface reconstruction and termination, including Si–H, H–Si–Si–H (dimer molecules), or oxygenated dimer bridges (H–Si–O–Si–H). We obtain the mechanical vibrational modes of the particles. Our results show that by changing the surface configuration one can control the symmetry and normal vibration modes, and enhance the polarizability, polarity, and light interactions (scattering, absorption, and depolarization/memory). The low frequency polarizability (Raman scattering) shifts spatially from the interior to the surface, while the infrared polarity remains on the surface, but its bandwidth narrows spectrally. The results support previous infrared absorption and light scattering and depolarization measurements, as well recent SERS, which enable Si nanoparticles to be an effective alternative to plasmonic metal particles. Molecular surface reconstruction in terms of Si dimers and bridges were suggested as the source of the novel nonlinear and anisotropic luminescence and photonic properties of Si nanoparticles. Such control affords potential for optimizing the design and operation of a wide range of opto-electronic advanced scattering and luminescence devices.
Bridging semiempirical and ab initio QM/MM potentials by Gaussian process regression and its sparse variants for free energy simulation
Authors: Snyder Ryan , Kim Bryant , Pan Xiaoliang , Shao Yihan , Pu Jingzhi 
Published: August 2023

Free energy simulations that employ combined quantum mechanical and molecular mechanical (QM/MM) potentials at ab initio QM (AI) levels are computationally highly demanding. Here, we present a machine-learning-facilitated approach for obtaining AI/MM-quality free energy profiles at the cost of efficient semiempirical QM/MM (SE/MM) methods. Specifically, we use Gaussian process regression (GPR) to learn the potential energy corrections needed for an SE/MM level to match an AI/MM target along the minimum free energy path (MFEP). Force modification using gradients of the GPR potential allows us to improve configurational sampling and update the MFEP. To adaptively train our model, we further employ the sparse variational GP (SVGP) and streaming sparse GPR (SSGPR) methods, which efficiently incorporate previous sample information without significantly increasing the training data size. We applied the QM-(SS)GPR/MM method to the solution-phase SN2 Menshutkin reaction, NH3+CH3Cl→CH3NH3++Cl−, using AM1/MM and B3LYP/6-31+G(d,p)/MM as the base and target levels, respectively. For 4000 configurations sampled along the MFEP, the iteratively optimized AM1-SSGPR-4/MM model reduces the energy error in AM1/MM from 18.2 to 4.4 kcal/mol. Although not explicitly fitting forces, our method also reduces the key internal force errors from 25.5 to 11.1 kcal/mol/Å and from 30.2 to 10.3 kcal/mol/Å for the N–C and C–Cl bonds, respectively. Compared to the uncorrected simulations, the AM1-SSGPR-4/MM method lowers the predicted free energy barrier from 28.7 to 11.7 kcal/mol and decreases the reaction free energy from −12.4 to −41.9 kcal/mol, bringing these results into closer agreement with their AI/MM and experimental benchmarks.
Melting curves of ice polymorphs in the vicinity of the liquid–liquid critical point
Authors: Piaggi Pablo M. , Gartner Thomas E. , Car Roberto , Debenedetti Pablo G. 
Published: August 2023

The possible existence of a liquid–liquid critical point in deeply supercooled water has been a subject of debate due to the challenges associated with providing definitive experimental evidence. The pioneering work by Mishima and Stanley [Nature 392, 164–168 (1998)] sought to shed light on this problem by studying the melting curves of different ice polymorphs and their metastable continuation in the vicinity of the expected liquid–liquid transition and its associated critical point. Based on the continuous or discontinuous changes in the slope of the melting curves, Mishima [Phys. Rev. Lett. 85, 334 (2000)] suggested that the liquid–liquid critical point lies between the melting curves of ice III and ice V. We explore this conjecture using molecular dynamics simulations with a machine learning model based on ab initio quantum-mechanical calculations. We study the melting curves of ices III, IV, V, VI, and XIII and find that all of them are supercritical and do not intersect the liquid–liquid transition locus. We also find a pronounced, yet continuous, change in the slope of the melting lines upon crossing of the liquid locus of maximum compressibility. Finally, we analyze the literature in light of our findings and conclude that the scenario in which the melting curves are supercritical is favored by the most recent computational and experimental evidence. Although the preponderance of evidence is consistent with the existence of a second critical point in water, the behavior of ice polymorph melting lines does not provide strong evidence in support of this viewpoint, according to our calculations.
Geometric analogy between quantum dynamics and curved space through quantum hydrodynamics
Authors: Shushi Tomer 
Published: August 2023

Abstract
In general relativity, the dynamics of objects is governed by the curvature of spacetime, which is caused by the presence of matter and energy. In contrast, in quantum mechanics, the dynamics is governed by the wavefunction, which completely describes the behavior of the particles. There is an ongoing effort to explore analogs of space and spacetime curvature in the context of quantum mechanics. Such analogies may reveal a deeper structure of quantum reality and its possible relations with Einstein’s theory of gravity. In this note, by coupling the non-relativistic Schrödinger equation with the heat equation and using the hydrodynamical formulation of quantum mechanics, we find that the dynamics of the particle is fully characterized by the normalized curvature of the wavefunction’s amplitude. Such a curvature obtains an analogy to the Ricci curvature of curved space in a Riemannian manifold. The proposed geometric correspondence provides a new pathway to explore quantum dynamics through the lens of differential geometry, the language of general relativity.
Trapping and sorting of nanoparticles by bowtie-nanohole plasmonic tweezers
Authors: Nie Yingdong , Xie Chaofeng , Zhu Guodong , Fang Yurui 
Published: August 2023

Abstract
Optical tweezers are a crucial tool for manipulating nanoscale objects, and have a wide range of applications in various fields. Bowtie-nanohole tweezers, a type of near-field optical tweezers, are particularly intriguing due to their strong near-field enhancement and unique characteristics. In this paper we provide a detailed discussion of the properties of bowtie-nanohole tweezers on trapping and sorting nanoparticles through theoretical and numerical results. It is discovered that the tweezers behave differently when trapping particles with varying refractive indices, leading to a discussion of sorting chiral particles. Moreover, the relative refractive index between the particles and the background solution greatly influences the trapping and sorting abilities of the tweezers. Finally, we investigate the performance of the tweezers at different wavelengths of incident light to determine the optimal working wavelength for trapping or sorting.