bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution mechanism of the dynamic excavation deformation of deep foundation pits with water-rich sand-pebble geology
Authors: Cheng Xuansheng , Ding Kai , Liu Haibo 
Published: January 2025

Abstract
This study focuses on the deep foundation pit with water-rich sand and gravel geology at the Southwest Jinfu Station of Chengdu Metro Line 6. A typical sand and gravel foundation pit standard cross-section is selected, and a plastic hardening constitutive model is employed. Considering the fluid-structure interaction during the excavation process, the study systematically analyzes the lateral displacement, bending moment variation, support axial force changes, as well as the evolution of surface settlement and foundation uplift of the underground continuous wall. The results indicate that as the excavation depth increases, the lateral displacement of the underground continuous wall gradually increases, with the displacement pattern transitioning from cantilever to bow, fish belly, and finally to a kick-foot shape. The bending moment increases with the excavation depth. The support axial force undergoes significant changes during excavation, especially during the steel support stage, where noticeable axial force loss occurs. Additionally, as the excavation depth increases, the settlement and uplift of the soil behind the wall also exhibit significant changes.
Generalized integral points on abelian varieties and the Geometric Lang–Vojta Conjecture
Authors: Phung Xuan Kien 
Published: January 2025

Let

f
:

A

→
B

f \colon \mathcal {A} \to B

be a family of abelian varieties over a compact Riemann surface

B
B

and fix an effective horizontal divisor

D

⊂

A

\mathcal {D} \subset \mathcal {A}

. We study

(
S
,

D

)

(S, \mathcal {D})

-integral sections

σ
\sigma

of the family

A

\mathcal {A}

where

S
⊂
B

S \subset B

is arbitrary. These sections

σ
\sigma

are algebraic and satisfy the geometric condition

f
(
σ
(
B
)
∩

D

)
⊂
S

f(\sigma (B) \cap \mathcal {D})\subset S

. Developing the work of Parshin, we establish new quantitative results concerning the finiteness and the polynomial growth of large unions of

(
S
,

D

)

(S, \mathcal {D})

-integral sections where

S
S

can vary and is required to be finite only in a thin analytic open subset of

B
B

. Such results are out of the range of purely algebraic methods and imply new evidence and interesting phenomena to the Geometric Lang–Vojta Conjecture.
Hepcidin, incident heart failure, and cardiac dysfunction in older adults: the ARIC study
Authors: Aboelsaad Iman A F , Claggett Brian L , Lamberson Victoria , Dorbala Pranav , Matsushita Kunihiro , Lutsey Pamela , Yu Bing , Lennep Brandon W , Farag Youssef M K , Shah Amil M , Buckley Leo F 
Published: January 2025

Abstract

Aims
Hepcidin regulates plasma and tissue iron levels. We studied the association of hepcidin levels with the risk of incident heart failure (HF) and cardiac dysfunction in older adults.

Methods and results
We included adults from the ongoing, longitudinal Atherosclerosis Risk in Communities (ARIC) study, who were free from prevalent anaemia and HF at Visit 5 (2011–13) and had available hepcidin and covariate data. Associations of plasma hepcidin levels with overall adjudicated incident HF, HF with reduced ejection fraction (HFrEF), and HF with preserved ejection fraction (HFpEF) were assessed using multivariable Cox proportional hazards regression models. Cross-sectional associations of hepcidin with echocardiographic measures of cardiac structure and function were estimated using multivariable linear regression models. The mean age was 75 ± 5 years old, and 56% were women. In fully adjusted models, lower hepcidin levels were associated with a higher risk of overall incident HF [hazard ratio [HR] [95% confidence interval (CI) per 50% lower hepcidin]: 1.15 [1.05–1.26]; P = 0.003] and HFpEF [HR (95% CI): 1.25 (1.10–1.42); P = 0.001]. Plasma hepcidin level was not significantly associated with the risk of incident HFrEF [HR (95% CI): 1.08 (0.94–1.24); P = 0.30]. Lower hepcidin levels were associated with higher E wave (P = 0.046), higher E/e′ ratio (P = 0.002), higher left atrial volume index (P = 0.005), and higher pulmonary artery systolic pressure (P = 0.02).

Conclusion
In community-dwelling older adults without anaemia, lower plasma hepcidin levels associate with a higher risk of incident HF (particularly HFpEF) and diastolic dysfunction.
Early Versus Late Atrial Fibrillation Recurrence After Pulsed Field Ablation: Insights From the admIRE Trial
Authors: Di Biase Luigi , Reddy Vivek Y , Bahu Marwan , Newton David , Liu Christopher F , Sauer William H , Goyal Sandeep , Iyer Vivek , Nair Devi , Osorio Jose , Mansour Moussa , Calkins Hugh , Wazni Oussama , Natale Andrea 
Published: January 2025

Structured Abstract

Background and Aims
Studies have shown correlations between early recurrence (ER) and late recurrence (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyze ER versus LR in patients with paroxysmal atrial fibrillation (PAF) undergoing pulsed field ablation (PFA).

Methods
Patients with symptomatic paroxysmal atrial fibrillation and ≥1 transtelephonic monitoring transmission during the blanking period were included (n=169). ER was defined as documented recurrence in the blanking period (days 1–90), and LR as recurrence in the evaluation period (days 91–365). Freedom from 12-month recurrence was estimated using Kaplan–Meier method. A Cox proportional-hazards regression model, with ER as the primary factor, and adjusted for age, sex, and body mass index, was used to estimate hazard ratios (HRs) and 95% CI.

Results
ER was observed in 20.1% (31/169) of patients (66.1±7.1 years, 35.5% female, 46.6±48.4-month PAF history). Time to first documented ER was 49 (37–61) days. Occurrence of LR was 16.7% (23/138) in patients without ER, 71.0% (22/31) in those with ER, and 87.0% (20/23) in patients whose ER onset occurred within the first 2 months. Twelve-month freedom from documented recurrence was significantly lower in patients with ER at 29.0% (95% CI, 13.1%–45.0%), versus 82.5% (95% CI, 75.9–89.1%) in those without ER (adjusted HR, 7.9; 95% CI, 4.1–15.1; P&lt;0.001).

Conclusion
This admIRE subanalysis demonstrated that PAF patients who experience ER after PFA are at a substantially higher risk for LR. The optimal duration of the blanking period post PFA need further assessments.
Regulatory role of miR-128-2-5p in serum exosomes on COL6A2 expression and postmenopausal osteoporosis
Authors: Lu Liangjie , Wang Lijun , Wang Huihan , Yang Minjie 
Published: January 2025

Abstract
This study investigates the influence of miR-128-2-5p within serum-derived exosomes (Exos) on COL6A2 expression and its implications in postmenopausal osteoporosis (POMP). Utilizing bioinformatics analysis, we identified 1317 differentially expressed genes (DEGs), primarily enriched in the focal adhesion pathway—a critical regulator of osteoblast adhesion. A significant gene, COL6A2, emerged as notably downregulated in POMP, possessing potential as a diagnostic marker. Predictive analysis linked the upstream miRNA miR-128-2-5p, highly enriched in Exos, with the regulation of COL6A2. Experimentally, Exos from POMP patients demonstrated elevated miR-128-2-5p levels, which inhibited COL6A2 expression in vitro, reducing osteoblast adhesion and exacerbating osteoporotic conditions. These findings highlight the pivotal role of exosomal miR-128-2-5p in bone metabolism, suggesting a novel molecular mechanism and a potential therapeutic target in POMP.
Rethinking the rise of early-onset gastrointestinal cancers: a call to action
Authors: Weinberg Benjamin A , Murphy Caitlin C , Freyer David R , Greathouse K Leigh , Blancato Jan K , Stoffel Elena M , Drewes Julia L , Blaes Anne , Salsman John M , You Y Nancy , Arem Hannah , Mukherji Reetu , Kanth Priyanka , Hu Xin , Fabrizio Anne , Hartley Marion L , Giannakis Marios , Marshall John L 
Published: January 2025

Abstract
Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed in patients under age 50 for reasons that remain poorly understood. The most significant change has been the increase in incidence rates of early-onset colorectal cancer, especially rates of left-sided colon and rectal cancers. Increases in gastric, pancreatic, and other gastrointestinal cancer diagnoses have further contributed to this trend. We formed a multidisciplinary Think Tank to develop a strategic, coordinated approach to studying early-onset gastrointestinal cancers. This area of research is challenging given multifactorial etiologies. We focused on epidemiology and the environment, the microbiome, and survivorship as key pillars to structure a research framework. We advocate a comprehensive strategy to (1) use existing biospecimens, especially those collected longitudinally, with correlation to exposures (the exposome); (2) standardize microbiome specimen collection and analyses of blood, tissue, and stool specimens to minimize contamination and biases; (3) prioritize mechanistic studies to evaluate findings from biomarker studies; and (4) explore the unique survivorship needs of this young population. These recommendations build upon prior efforts with the goal of streamlining research into this important field of study while minimizing redundant efforts. We hope that our findings serve as a clarion call to motivate others to discover why young individuals are being diagnosed with gastrointestinal cancers at such an alarming rate and how to best support those who have been diagnosed.
The impact of the COVID-19 on the antifungal consumption and antifungal resistance in Candida species isolated from the blood cultures of critically ill patients in intensive care units
Authors: Kara Emre , Metan Gokhan , Gülmez Dolunay , Arikan-Akdagli Sevtap 
Published: January 2025

Abstract
Incidence of Candida species increased in critically ill COVID-19 patients in intensive care units. This study aimed to investigate the impact of the COVID-19 pandemic on antifungal consumption and Candida species distribution in bloodstream infections. We observed that a significant increase in non-albicansCandida species cases (P = .005) in 2021 coincided with higher rates of fluconazole resistance (P = .002) and increased minimum inhibitory concentrations for echinocandins (P = .012). Notably, voriconazole consumption and increased MIC levels positively correlated with both Candida albicans and non-albicansCandida species. This study underscores the importance of judicious antifungal use during the COVID-19 pandemic.
Analysis of the Gaia DR3 photometry of the dwarf planet Eris
Authors: Ortiz J L , Morales N , Gutiérrez P J 
Published: January 2025

ABSTRACT
Eris, one of the five official dwarf planets, is slightly smaller than Pluto and notable for its high geometric albedo and homogeneous surface, which has hindered a clear determination of its rotation period. Recently, it was shown that Eris is tidally locked to the 15.786-d orbit of its satellite, Dysnomia. Our analysis of Eris’ Gaia DR3 photometry reveals a strong periodicity peak at 18.852 $\pm$ 0.003 h, which is the most prominent in the Lomb–Scargle periodogram, with a slightly stronger signal than the 15.77 $\pm$ 0.02-d period also present in the data. We analysed whether the newly identified period could be an artefact, but found no reason other than a phenomenon in Eris. Since Dysnomia is too faint to account for the photometric variability, a potential explanation for either of the periodicities could be the presence of an unknown close-in satellite. An additional satellite, undetectable so far by the Hubble Space Telescope (HST), could also explain Dysnomias non-Keplerian orbit and could lower Eris’s density to $\sim$2000 kg m−3, consistent with other similar-sized Trans-Neptunian Objects (TNOs) and Triton. It would also decrease Eris’s albedo by $\sim$10 per cent, aligning it more closely with expected values. However, this possibility also has considerable problems, and other scenarios are explored.
Supporting community translation of lung cancer screening: A web-based decision aid to support informed decision making
Authors: Studts Jamie L , Thurer Richard S , Studts Christina R , Byrne Margaret M 
Published: January 2025

Abstract
Background: Results of the National Lung Screening Trial create the potential to reduce lung cancer mortality, but community translation of lung cancer screening (LCS) has been challenging. Subsequent policies have endorsed informed and shared decision-making and using decision support tools to support person-centered choices about screening to facilitate implementation. This study evaluated the feasibility and acceptability of LuCaS CHOICES, a web-based decision aid to support delivery of accurate information, facilitate communication skill development, and clarify personal preferences regarding LCS—a key component of high-quality LCS implementation. Methods: Using a parallel groups randomized trial, the study investigated the feasibility and acceptability of LuCaS CHOICES decision aid in comparison to the National Cancer Institute’s Lung Cancer Screening website. Three waves of self-report data were collected: baseline (PRE), 2 weeks post-baseline (POST), and 4 months post-baseline (FOL). Participant accrual and intervention access data were also collected to evaluate methodological feasibility for conducting a larger subsequent trial. Results: Participants assigned to LuCaS CHOICES (n = 25) and the NCI website (n = 25) interventions reported similar, favorable levels of intervention feasibility and acceptability that exceeded a priori criteria. Methodological feasibility was partially supported for the proposed accrual and retention goals, but accrual was slower than hypothesized, and documented exposure to the digital interventions was suboptimal per a priori standards. Conclusions: Overall, both interventions demonstrated intervention feasibility and acceptability. In addition, the proposed methods achieved desired levels of retention and overall data collection. Modifications to enhance intervention engagement should be explored prior to further testing. Subsequent steps involve conducting a randomized clinical trial to evaluate the effect of LuCaS CHOICES on informed decision making and preference-concordant screening behavior, supporting LCS translation into community settings.
Long-Term Revision-Free Survival Following Operative Fixation of Femoral Neck Fractures in Young Adults
Authors: Panarello Nicholas M. , Gu Alex , Dance Sarah , Harrington Colin J. , Ferraro Samantha L. , Renninger Christopher H. , Sterling Robert S. , DeBritz James N. 
Published: January 2025

OBJECTIVES:
To identify the rate of fixation failure following femoral neck fracture (FNF) fixation in young adults within a national database.

METHODS:
Design: Retrospective cohort study

Setting:
National all-payer claims database

Patient Selection Criteria:
Adults between 18 and 49 years of age who underwent operative fixation for FNF (AO/OTA 31-B) between January 2010 and April 2019 were identified.

Outcome Measures and Comparisons:
The primary outcome measure was five-year risk of revision surgery for fixation failure following operative management of FNF. Additional data variables included rate of fixation failure following open versus closed reduction techniques and the rate of revision fixation, intertrochanteric osteotomy for nonunion or malunion, and conversion to arthroplasty.

RESULTS:
A total of 3,534 young adults underwent operative fixation of a FNF during the study period. The mean age of the study population was 41.1 +/- 3.91 years (18-49) and a majority were male (52.6%). The five-year revision-free survival of young adults who underwent operative fixation for FNF was 86.1% (95% CI 85.5-89.1%). Four-hundred ninety-two patients (13.9%) required revision surgical intervention for fixation failure, including 210 (5.9%) revision fixation procedures and 21 (0.6%) intertrochanteric osteotomies; two hundred sixty-one (7.4%) patients underwent conversion to arthroplasty. There was no significant difference in rate of fixation failure when comparing open (n=392, 14.9%) and closed (n=100, 13.3%) reduction techniques (p=0.351).

CONCLUSIONS:
Following operative management of FNF in young adults, fixation failure due to avascular necrosis, nonunion/malunion, or posttraumatic arthritis occurred at a rate of 13.9%. There was no difference in the rate of treatment failure between open and closed reduction.

LEVEL OF EVIDENCE:
Therapeutic Level IV
Prolonged Preservation of up to 24h at 10°C does not Impact Outcomes after Lung Transplantation
Authors: Hoetzenecker Konrad , Ali Aadil , Campo-Cañaveral de la Cruz Jose , Schwarz Stefan , Crowley Carrasco Silvana , Romero Roman Alexandra , Aladaileh Mohammed , Benazzo Alberto , Jaksch Peter , Wakeam Elliott , Aversa Meghan , Keshavjee Shaf , Cypel Marcelo 
Published: January 2025

Objective:
To determine the impact of prolonged storage of donor lungs at 10°C of up to 24h on outcome after lung transplantation.

Background:
An increasing body of evidence suggests 10°C as the optimal storage temperature for donor lungs. A recent study showed that cold ischemic times can be safely expanded to >12h when lungs are stored at 10°C. However, it is currently unknown how long donor lungs can be preserved before they deteriorate in function.

Methods:
Patients who received a donor lung stored at 10°C between 11/2020 and 06/2023 at the lung transplant programs of Toronto, Vienna and Madrid were included in this retrospective analysis. After excluding EVLP-cases, recipients were grouped based on the total preservation times of their donor organs (<12h: n=48; 12-18h: n=109; ≥18h: n=24). 372 recipients who had received an organ stored on-ice during the study period served as a control group.

Results:
Length of lung preservation ranged from 2h 27min to 29h 33min (mean 14h 06min). Despite these prolonged preservation times, early postoperative outcomes were excellent. Median length of mechanical ventilation did not differ between the three study groups (<12h: 41h [IQR 24-109]; 12-18h: 56h [IQR 24-143] and ≥18h: 59h [IQR 28-108]; P=0.493). ICU length of stay (6 d [4-14]; 8 d [4-23]; 8 d [5-32]) and hospital length of stay (32 d [20-48]; 29 d [20-50]; 26 d [17-50]) were also similar. Furthermore, length of donor organ preservation had no impact on patient survival (log rank P=0.413).

Conclusions:
Prolonged static preservation of donor lungs at 10°C for up to 24 hours is safe and does not impair short-intermediate outcomes after lung transplantation.
The Diagnostic Yield of Genomic Sequencing-Based Genetic Kidney Disease Testing in Kidney Transplant Candidates: Experience at an Urban US Transplant Center
Authors: Abu Al Rub Fadee , Elsurer Afsar Rengin , Fleetwood Vidya A. , Bastani Bahar , Randall Henry , Nazzal Mustafa , Varma Chintalapati , Afsar Baris , Jackson Holly , Yount Shannon , Wooley Cody , Light Jennifer , Davis Virginia , Caliskan Yasar , Lentine Krista L. 
Published: January 2025

Background.
Recent studies suggest that approximately 10% of patients with chronic kidney disease (CKD) have disease-causing genetic variants, an observation relevant to evaluation of kidney transplant candidates.

Methods.
We retrospectively investigated the diagnostic yield of genetic testing in kidney transplant candidates evaluated at our program (January 1, 2021–December 8, 2022). Inclusion criteria were as follows: first-degree relative(s) with CKD/end-stage kidney disease (ESKD), early-onset CKD, focal segmental glomerulosclerosis, cystic kidney disease, alternative complement pathway-associated diseases, or ESKD of unknown cause.

Results.
One hundred eleven patients underwent genetic kidney disease testing. The most common indication for testing was early-onset CKD (34.2%), followed by a family history of CKD (23.4%), focal segmental glomerulosclerosis (18.0%), cystic kidney disease (9.0%), alternative complement pathway diseases (3.6%), and ESKD of unknown cause (11.7%). Overall diagnostic yield was 46.9% (52/111), and yield was highest among candidates with a family history of CKD (61.5%; 16/26). Among cases with positive testing, the most common diagnostic variant was APOL1, with 2 renal risk variants identified in 57.7% (30/52), while monogenic causes of CKD were identified in 42.3% (22/52). Genetic testing led to further evaluation or to a different diagnosis than the initial clinical diagnosis in 8.1% (9/111) of the cohort. For 24 transplant candidates, their identified diagnostic variants indicated the need for genetic testing of related living donor candidates; of these, 6 living donor candidates were evaluated and underwent testing, of whom donation was excluded in 1 candidate.

Conclusions.
Pretransplant genetic testing increases understanding of CKD cause, and provides information for living donor evaluation and risk assessment of posttransplant disease recurrence.
Modeling Retinitis Pigmentosa 59:DhddsT206A andDhddsK42E knock-in mutant mice are phenotypically similar
Authors: Nguyen Mai N. , Chakraborty Dibyendu , Messinger Jeffrey , Sherry David M. , Fliesler Steven J. , Pittler Steven J. 
Published: January 2025

ABSTRACTDehydrodolichyldiphosphatesynthase (DHDDS) is an essential enzyme required for several forms of protein glycosylation in all eukaryotic cells. Surprisingly, three mutant alleles, (DhddsK42E/K42E(K42E/K42E),DhddsT206A/K42E(T206A/K42E), and found in only one patient,DhddsR98W/K42E(R98W/K42E) have been reported that cause non-syndromic retinitis pigmentosa (RP59), an inherited retinal degeneration (IRD). Because T206A was only observed heterozygously with the K42E allele in RP59 patients, we used CRISPR/CAS9 technology to generate T206A/T206A, and subsequently T206A/K42E alleles in mice to assess the contribution of the T206A allele to the disease phenotype, to model the human disease, and to compare resulting phenotypes to our homozygous K42E mouse model. By postnatal (PN) 12-mo, T206A/K42E mice exhibit significant reduction of inner nuclear layer thickness as was observed in K42E/K42E mice. No change in outer nuclear layer thickness is observed in all mutant phenotypes up to PN 12 mo. Electroretinography (ERG) showed a significantly reduced b-wave without a-wave decrement and by PN 3-mo, ERG c- and d-wave responses were significantly attenuated in all phenotypes. Consistent with a reduction in inner nuclear layer thickness seen by OCT and cell loss observed by histology, bipolar and amacrine cell densities were reduced in allDhddsmutant phenotypes compared to PN 8-12 mo age-matched controls. These results indicate that theDHDDST206A allele causes retinal disease independent of the K42E allele, and that there likely is a common disease mechanism involving RP59-associatedDHDDSmutations. We conclude that the physiological basis of retinal dysfunction in RP59 involves defective signaling in the inner retina resulting in bipolar/amacrine cell degeneration.
Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease
Authors: Müller Laura , Özdüzenciler Pelin , Schedlich-Teufer Charlotte , Seger Aline , Jergas Hannah , Fink Gereon R. , Willbold Dieter , Sommerauer Michael , Barbe Michael T. , Tamgüney Gültekin 
Published: January 2025

ABSTRACTParkinson’s disease is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for Parkinson’s disease and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with Parkinson’s disease and isolated REM sleep behavior disorder, a precursor to Parkinson’s disease, had elevated concentrations compared to healthy controls. Sensitivity and specificity were 83% and 65% for Parkinson’s disease versus controls and 89% and 62% for isolated REM sleep behavior disorder versus controls. The findings highlight sFIDA’s potential for diagnosing synucleinopathies.