bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of early administration of tolvaptan on pleural effusion post-hepatectomy
Authors: Iida Hiroya , Maehira Hiromitsu , Mori Haruki , Nitta Nobuhito , Maekawa Takeru , Takebayashi Katsushi , Kaida Sachiko , Miyake Toru , Tani Masaji 
Published: March 2023

Abstract
Purpose: In this study, the efficacy of tolvaptan administration at the early stage post-hepatectomy was evaluated to control pleural effusion and improve the postoperative course.
Methods: Patients were administered tolvaptan (7.5 mg) and spironolactone (25 mg) from postoperative day 1 to 5 (tolvaptan group, n=68) for 13 months. Early administration of tolvaptan was not given in the control group (n=68) but diuretics were appropriately administered according to the patient's condition. The amount of pleural effusion on computed tomography on postoperative day 5 was compared between the two groups.
Results: The amount of pleural effusion and increase in body weight on postoperative day 5 showed significant differences in both groups (p<0.001 and p=0.019, respectively). However, the rate of pleural aspiration and the duration of postoperative hospitalization did not show any significant differences. The amount of intraoperative blood loss and lack of early administration of tolvaptan were identified as independent risk factors contributing to pleural effusionon multivariate analysis.
Conclusion: Early administration of tolvaptan to post-hepatectomy patients was found to be capable of controlling postoperative pleural effusion and increase in body weight, but it did not reduce the rate of pleural aspiration or the hospitalization period.
Increasing incidence of syphilis among men living with HIV in Croatia during the COVID-19 years 2020 and 2021
Authors: Begovac Josip , Pintar Vanja Romih , Vrsaljko Nina , Močibob Loris , Bogdanić Nikolina , Zekan Šime , Rode Oktavija Đaković 
Published: March 2023

Abstract
We conducted a nationwide longitudinal observational study to estimate the incidence of syphilis in a cohort of male persons living with HIV (PLWH) in Croatia in the pre-COVID-19 and COVID-19 years. Data were reviewed and extracted from the clinical database. We analyzed 1187 PLWH (> 18 years) in care in Croatia from 2018 to 2021 and used Poisson regression to calculate rates. We observed a 91.4% increase in incidence between 2019 and 2020; the overall rate was 6.0/100 person-years, and the annual rate ranged from 3.3/100 person-years in 2018 to 9.3/100 person-years in 2021. We found higher rates in men who have sex with men, PLWH with a baseline history of syphilis, PLWH with a more recent HIV diagnosis, and a lower rate in those who had clinical AIDS. The rate of syphilis serological testing was 3.5% lower in 2020 compared to 2019. Recurrent syphilis was more likely asymptomatic compared to the first episodes. In conclusion, during the COVID-19 epidemic years there was a huge increase in syphilis. Results highlight the need for enhanced and novel prevention interventions.
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
Authors: Bousiges Olivier , Cretin Benjamin , Muller Candice , Botzung Anne , Sanna Lea , Anthony Pierre , Philippi Nathalie , Demuynck Catherine , Blanc Frédéric 
Published: March 2023

Abstract

Background:ApoE4 as a risk factor for AD is no longer a matter of debate. However, it is still an issue for dementia with Lewy bodies (DLB).We wanted to determine the involvement of ApoE4 according to different clinical parameters in our cohort of patients from Strasbourg.Methods:ApoE genotyping was performed on the AlphaLewyMA cohort. In this cohort, 197 patients were genotyped. Among them 105 DLB patients, 37 Alzheimer’s disease (AD), 29 comorbidity AD/DLB and 26 control subjects (CS). These groups are also classified according to the stage of evolution of the disease: prodromal or demented. We analyzed other parameters in relation to ApoE4, such as socio-educational levels (SEL) and Alzheimer CSF biomarkers (t-Tau, P-Tau, Aβ-42 and Aβ40).Results:There were significantly more ApoE4 carriers in the AD (51.4%) and AD/DLB (72.4%) groups compared to the DLB (25.7%) and CS (11.5%) groups (P<0.0001). No significant difference was found between the percentage of ApoE4 in the DLB and CS groups, idem between AD and AD/DLB groups. For AD group, we find a correlation between the age of onset of the disease and the SEL. For DLB group, the correlation does not reach significance despite a strong trend (p = 0.056). Interestingly, in this latter group, taking the median of SEL (Education=11 years, i.e. one year before bachelor), the group of patients with high SEL (≥ 11) has significantly more patients with ApoE4 than the group of patients with low SEL (<11). Finally, the AD biomarkers do not seem to be impacted by the presence of ApoE4, except for Aβ42. DLB ApoE4 demented patients show a more marked decrease of CSF Aβ42.Conclusions:ApoE4 does not appear to be a risk factor for “pure” DLB patients with the possible exception of patients with high SEL. In the DLB group, ApoE4 would be responsible for the Aβ42 decrease between the prodromal and demented group, suggesting a strong link between ApoE4 and amyloidopathy thus confirming its strong link with AD.Trial registration: ClinicalTrials.gov, (AlphaLewyMa, Identifier: NCT01876459)
İSTATİSTİKLER IŞIĞINDA YAŞLI BAKIM HİZMETLERİ ALANINDA ÜLKEMİZDE UYGULANAN POLİTİKALAR
Authors: SAKAR Zeynep Müjde 
Published: March 2023

Bu çalışma ile ülkemizde gerçekleştirilen yaşlı bakımıyla ilgili gelişmeler ele alınmıştır. Yaşlı bakımının dönem içerisinde geçirdiği değişim vurgulanmaya çalışılmış ve çekirdek aile, köyden kente göç gibi olguların üzerinde durularak yaşlı bakımıyla ilişkilendirilmiştir.
Çalışmamızın öznesi olan “yaşlı bakımı” konusunda Cumhuriyetin ilk yıllarında çalışmalar yeterli ölçüde değildir. Yaşlı bakımıyla ilgili çalışmalar genel manada yerel bir özellik taşıyordu. Bu dönemde Genellikle belediyeler üzerinden yürütülmeye çalışılan sistem önemli ölçüde ihtiyacı karşılayamamıştır. İhtiyacı karşılama konusunda bir takım sıkıntıların çıkmasıyla bu alanda önemli çalışmalar yapıldı Öyle ki 1960’larla birlikte hız kazanacak olan çalışmalar bugünün şekillenmesin de etkili olacaktı.
Özellikle 1961 Anayasası’nda sosyal devletten bahsedilmesi ve 1963’te Sosyal Hizmetler Genel Müdürlüğünün kurulması bu yolda atılan önemli adımlar arasındadır. Ayrıca planlı kalkınma döneminin başlaması ve konumuzla ilgili bir takım çalışmaların üzerinde durulması gelişimin hızlanmasını sağlamıştır. Bütün bunların yanında 2828 sayılı Sosyal Hizmetler ve Çocuk Esirgeme Kurumu Kanunu’nun kabul edilmesiyle ciddi anlamda mesafe alınmıştır. Son dönemde yapılan evde bakım hizmeti çalışmaları, destekleyici bakım hizmeti ve yaşlı yaşam evi gibi uygulamalar bu konuda ne kadar ilerlediğimizin bir kanıtı niteliğindedir
Segments and Subclasses of Pseudo-Borrowed Onyms in the German Literary Language
Authors: Volkova A. B. , Kobenko Yu. V. 
Published: March 2023

The article describes a system-structural analysis of 311 German pseudo-borrowings. The research objective was to classify pseudo-borrowed onyms in the German literary language as pseudo-borrowings or proper names. Pseudo-borrowed onyms are different from assimilates, erratives, pseudomotives, homeonims, memorative fictionyms, and pseudo-Latin cognomens. The sampling was based on six criteria: 1) the onyms developed from a morpheme of the donor language; 2) they violate the principle of reversibility; 3) they belong to the category of nomina propria ; 4) they are capitalized; 5) they belong to the German language; 6) they imitate a foreign language. German pseudo-borrowed onyms are represented by fourteen segments, the largest of which are the Maccaronian (Common Romanian) segments of pseudo-Latinisms (88 units, 28.3 %) and pseudo-Italianisms (80 units, 25.7 %). The largest onymic subclasses are represented by anthroponyms in the subset of realonyms (36 units, 11.6 %) and fictionyms (149 units, 47.9 %), as well as pragmonyms in the pseudo-Italian segment (70 units, 22.5 %). Fictionyms (166 units, 53 %) dominate over realonyms and come from translated fiction. Pseudo-borrowed onyms differ from appellants in their word formation because they are not tied to prestigious donor languages. The hybrid specificity of pseudo-borrowed onyms make it impossible to localize them as onymic or appellative.
High-sensitivity Troponin (hs-Tn) for Cardiovascular Risk
Prognostication: A Systematic Review and Meta-analysis
Authors: Sagris Marios , Antonopoulos Alexios S. , Angelopoulos Andreas , Papanikolaou Paraskevi , Simantiris Spyridon , Vamvakaris Constantinos , Koumpoura Alkmini , Farmaki Maria , Antoniades Charalambos , Tsioufis Constantinos , Tousoulis Dimitris 
Published: March 2023

Background:
Chronic low-grade inflammation is involved in coronary atherosclerosis
progression whereas recent research efforts suggest that preventative methods should be
tailored to the “residual inflammatory risk”. As such, modalities for the early identification of
the risk have to be investigated.

Methods:
We performed a systematic review and meta-analysis according to the PRISMA
guidelines. Any study that presented the prognostic value of high sensitivity troponin (hs-cTn)
of vascular inflammation in stable patients without known cardiac heart disease was considered
to be potentially eligible. The Medline (PubMed) database was searched up to April 22,
2021. The main endpoint was the difference in c-index (Δ[c-index]) with the use of hs-cTn
for major adverse cardiovascular events (MACEs), cardiovascular and all-cause mortality.
We calculated I2 to test heterogeneity.

Results:
In total, 44 studies and 112,288 stable patients without known coronary heart disease
were included in this meta-analysis. The mean follow-up duration of the whole cohort was 6.8
± 1.1 years. 77,004 (68.5%) of the patients presented at low cardiovascular risk while 35,284
(31.5%) in high. The overall pooled estimate of Δ[c-index] for MACE was 1.4% (95%CI:
0.7-2.1, I2=0%) and for cardiovascular death 1.3% (95%CI: 0.3-2.3, I2=0%). Finally, the overall
pooled estimate of Δ[c-index] for all-cause mortality was 3% (95%CI: 1.9-3.9, I2=86%),
while high heterogeneity was observed between the studies.

Conclusion:
The predictive usefulness of changes in hs-cTn measures in stable individuals
with either high or low cardiovascular risk, demonstrates that assessing vascular inflammation
in addition to clinical risk factors enhances risk prediction for cardiovascular events and allcause
mortality. Further prospective studies are necessary to confirm these findings and assist
clinical decision-making regarding the most optimal prevention strategy.
Individual and Combined Antifungal Activities of Artemisia herba alba and
Ammoides verticillata Essential Oils against the Three Main Pathogenic
Microorganisms of Potato
Authors: Medjahed Ilyas Moubarek , Benyelles Nassira Gaouar , Senouci Hanane , Gaouar Manel Yadi 
Published: March 2023

Background:
Potatoes are extremely important compared to other vegetable crops. Several species of fungi cause severe damage to different components of the plant (leaves, stems, and tubers), leading to significant losses during cultivation and even after harvest. In the framework of the investigation for alternative methods against the proliferation of these fungi, the present work focuses on the study of the antifungal effect of essential oils of some plants that could be used to solve these problems without the use of harmful chemical substances.

Aim and Purpose:
This study aims to discuss the chemical composition of essential oils of Artemisia herba alba and Ammoides verticillata and evaluate their in vitro and in vivo antifungal activities in order to prevent fungal diseases of potatoes and replace chemical pesticides that cause neurodegenerative diseases.

Methods::
Essential oils extracted from the aerial parts of the plants Artemesia herba alba and Ammoides verticillata were analyzed by gas chromatography-mass spectrometry (GC/MS) and tested individually and in combination for their antifungal effects against Fusarium solani, Penicillium expansum, and Aspergillus flavus, by the radial growth technique.

Results:
The essential oil of A. herba alba was mainly composed of hydrocarbon monoterpenes (80.8%), while the oil of A. verticillata was mainly composed of oxygenated monoterpenes (54.4%). The study on the antifungal effect of essential oils in vitro showed that essential oil of A. Verticillata was more effective against P. expansum (64.40%) than A. flovus (41.10%) and F. solani (53.30%), and the oil of A.herba alba was more effective against A. flavus (54.40%) and (42%) F. Solani. While the combination of these two essential oils of A. verticillata and A. herba-alba gave excellent results, i.e., 100% against P. expansum and A. flavus and 94.40% against F. solani and provided an in vivo protection to the potato in the range of 80% to 90% against the three fungi.

Conclusion:
A. herba alba and A. verticillata individual and combined essential oils are very effective antifungal biocides that can be used as an alternative to chemical pesticides to prevent their harmful effects on health.
Comparison of Serum Procalcitonin Levels between Patients with Acute
Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and
Patients with Chronic Obstructive Pulmonary Disease
Authors: Jafari Nejad Sakineh Haj , Behzadi Anahita , Shafiepour Mohsen , Dalfardi Behnam , Langari Ahmad Alinaghi , Ahmadipour Habibeh , Shafahi Ahmad , Fekri Mitra Samareh 
Published: March 2023

Background:
This study aimed to compare the serum levels of procalcitonin in the pa-tients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and the patients with chronic obstructive pulmonary disease (COPD) in the emergency ward of Afzalipour Hospital in Kerman.

Methods:
This cross-sectional study was conducted on 45 patients with stable COPD and 45 pa-tients with AECOPD. Patients were divided into four groups based on COPD severity assessment. Serum procalcitonin levels were measured using an ELISA kit..

Results:
The mean age of patients in the exacerbation and the stable group was 60.97 ± 12.61 and 62.53 ± 11.04 years, respectively. Serum procalcitonin levels in two exacerbation groups (215.22 ± 19.84) were higher than stable groups (127.92 ± 8.97) (P = 0.001). The accuracy of this test for diagnosing acute attack in terms of AECOPD was 77%, and the serum procalcitonin level of 132.6 was found to be the best cut-off point to diagnose acute disease. The mean serum procalcitonin le-vels of stage D patients in the acute attack group were substantially higher than those of stages D and B patients in the stable group (P = 0.001). Serum procalcitonin levels were related to body mass index (P = 0.01), post-bronchodilator FEV1/FVC (P = 0.028), and the number of hospitalizations per year (P = 0.001). By increasing the serum procalcitonin levels, BMI and number of admissions per year increase, and post-bronchodilator FEV1/FVC decreases.

Conclusion:
The mean serum levels of procalcitonin in the group with attacks due to COPD was significantly higher than the stable group.
Coronary Cameral Fistula Disclosed by Echocardiography: A Case Report of
Typical Findings and Literature Review
Authors: Chan Wan Khey , Chang Yi Yao , Li Ai Hsien 
Published: March 2023

Background:
Coronary cameral fistula is a rare cardiovascular anomaly, and usually needs advanced image modalities, such as computerized tomography and/or angiography, to confirm its existence. A few reports in the literature have addressed the role of medical ultrasound in the diagnosis of this disease, without a comprehensive summary of all the valuable echocardiographic features in its diagnosis.

Case Presentation:
Hereby, we presented an 80-year-old lady with exertional dyspnea and angina. We diagnosed coronary cameral fistula from the left anterior descending artery into the left ventricle by echocardiography with "intramyocardial vascular channel and the diastolic flow", and "multiple diastolic flow jets into heart chamber from heart wall". We confirmed the diagnosis with coronary angiography later. In the discussion, we make a comprehensive summary to conclude all the echocardiographic findings of this disease into 3 categories.

Conclusion:
We believe the identification of those findings will prompt the early diagnosis of this rare anomaly.
Evaluation of the Frequency of Tentorial Hypoplasia and Accompanying Gyral
Herniation using MRI
Authors: Turan Aynur , Kaplanoglu Hatice , Akdağ Tuba , Yıldırım Ferhat , Güven Selda , Hekimoğlu Baki 
Published: March 2023

Purpose:
The cerebellar tentorium, the second-largest dural reflection in the brain, separates supratentorial and infratentorial structures. This study aimed to
determine the frequency of tentorial hypoplasia (TH) and gyral herniation and their relationship with clinical findings.

Methods:
The standard brain MRIs were examined retrospectively. The presence of TH and laterality were investigated. If hypoplasia was accompanied by a
gyrus extending inferior to the line where the tentorium should be located, this was recorded as tentorial hypoplasia-herniated gyrus (TH-HG),
while the cases with hypoplasia alone were noted as isolated TH. It was also determined which gyrus or gyri were herniated. The clinical findings
of the patients were obtained, and the correlation between HG was explored.

Results:
Standard brain MRIs of the 2051 patients were evaluated. Two hundred ten patients were excluded from the study due to different intracranial
disorders, and 1841 patients, 739 (40.1%) males, and 1102 (59.9%) females, were included. Isolated TH or TH-HG was present in 56 patients,
resulting in a prevalence of 3.04%. Of the patients with TH or TH-HG, 15 were men, and 41 were women. TH and TH-HG were significantly more
common in women (p=0.038). TH-HG was unilateral in 22 (39.2%) patients and bilateral in 21 (37.5%). Left TH was found in 11 (19.6%) patients,
left TH-HG in 29 (51.7%), right TH in eight (14.2%), and left TH-HG in 35 (62.5%).

Conclusion:
Hypoplasia of the tentorium is a rare and unknown anomaly that can be easily diagnosed using MRI, and different gyral herniations may
accompany TH.
Bone Augmentation Techniques with Customized Titanium Meshes: A Systematic Review of Randomized Clinical Trials
Authors: De Angelis Nicola , Kassim Zethy Hanum , Mohd Yusof Eleena , Yumang Catherine , Menini Maria 
Published: March 2023

Background:
A correct tridimensional implant placement requires a sufficient amount of bone to completely satisfy the prosthetic reconstruction. Several techniques can be used to recreate the bone quantity. Among them, titanium meshes have shown great potential in space maintenance and fewer complications in case of exposure. Recently, 3D CAD, CAM technology, and specifically SLM have been used to produce customized meshes in titanium alloy. The aim Purpose of this systematic review is to evaluate new customized meshes compared to traditional ones in terms of new volume of generated bone and the incidence of complications.

Materials and Methods:
A MEDLINE/PubMed literature search was performed to find relevant randomized controlled clinical trials published in English up to and including December 2022. The Cochrane Database of Systematic Reviews and SCOPUS were also searched. The main keywords used in the search were: titanium meshe(s), customized titanium meshe(s), combined with AND/OR as Boolean operators, and bone augmentation with/and/or titanium mesh.

Results:
The electronic search identified 1002 papers in total, and after duplicate removal, 500 articles were screened. After a manual screening of the title and abstract, 488 studies were excluded, and 12 articles' full text of 12 articles was analyzed. Further analysis was performed to make sure that the articles matched the inclusion/exclusion criteria of the present review. Six additional articles were excluded in this phase. No meta-analysis was performed due to the heterogeneity of the data.

Conclusion:
By using traditional or customized devices with the newly generated bone volume allowed the implant placement in all cases. Complications were mainly reported as exposure during the healing phase, but the conclusions of whether customized or conventional systems perform one better than the other are still inconclusive.
Differences of Enamel Microhardness Post External Bleaching After Application with Casein Phosphopeptide Amorphous Phosphate (CPP-ACP) and 5% Sodium Fluoride (NAF)
Authors: Irmaleny Irmaleny , Prisinda Diani , Susilo Marietta 
Published: March 2023

Background:
Bleaching is an effort to lighten the color of teeth through the application of chemicals. One of the side effects of bleaching is that it causes demineralization so that the hardness of the enamel will decrease. The hardness of the enamel can be returned back through the mineral laying process, namely remineralization.

Objective:
The purpose of this study was to determine whether there were differences in post-bleaching enamel hardness after Casein Phosphopeptide Amorphous Phosphate (CPP-ACP) or 5% sodium fluoride (NaF) application.

Methods:
In this in-vitro research, bleaching was applied to 30 lower premolars that were divided into three groups, the first group without remineralization, the second group remineralization with CPP-ACP, and the third group remineralization with NAF. Enamel microhardness was measured using Vickers Hardness Tester Machine before bleaching, immediately after bleaching, after application of remineralization pastes, and after 7 days. The teeth were bleached with 40% hydrogen peroxide and underwent remineralization for 7 days.

Results:
The results showed differences in enamel microhardness after using CPP-ACP or 5% sodium fluoride (NaF) application, and the highest post-bleaching enamel hardness was after 5% NaF application. The data were analyzed and tested using ANOVA to measure the differences in hardness between more than 2 groups, and using the post hoc student t-test to measure the differences in violence between the 2 groups. Natural remineralization can occur with saliva but not optimally; therefore, additional remineralizing agents are needed.

Conclusion:
The conclusion of this study was that 5% NaF used as a remineralization agent after in-vitro bleaching could increase enamel microhardness more than CPP-ACP after 7 days of application.