bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and correlates of destructive behaviors in the US Naval Surface Forces from 2010–2020
Authors: Lai Kevin , Jameson Jason T. , Russell Dale W. 
Published: April 2023

Abstract
Purpose
To estimate the prevalence of domestic violence, sexual assault, and suicide for United States Navy (USN) personnel between 2010 and 2020 and identify potential associated factors.

Methods
Official report data were used to calculate prevalence rates and odds ratios, accounting for sample and general USN population demographic data to assess differences in over- or underrepresentation of destructive behaviors.

Results
Domestic violence and sexual assault offenders tended to be younger lower-ranked males. For sexual assaults, offenders were three times more likely to be senior to the victim, which was not the case for domestic violence. Females were overrepresented in terms of suicidal ideation and attempts relative to the USN population, while males accounted for more actual suicides. The relative rates of suicidal ideation and attempts for females exceeded those for males (i.e., comparing the sample rate against the USN male and female populations), but the sample proportion for completed suicides (compared to the USN population) were greater for males than for females. Those in the junior enlisted (E1–E3) paygrades exhibited greater odds of suicide attempts versus suicidal ideations relative to those in the Petty Officers (E4–E6) paygrades, although E4–E6s completed more suicides.

Conclusion
The descriptive profile of destructive behaviors in a representative sample of USN personnel provides an overview of the possible factors associated with destructive behaviors and includes an exploration of the relational dynamics and nature of the incidents. The results suggest that sexual assault and domestic violence are characterized by unique relational dynamics and that these destructive behaviors should not necessarily be classified together as male-oriented aggressions (i.e., mainly perpetrated by males against female victims). Those in the E1–E3 and E4–E6 paygrades displayed different patterns in suicidal ideation, attempts, and actual suicides. The results highlight individual characteristics to help inform the development of targeted policies, practices, and interventions for military and other hierarchical organizations (e.g., police).
Exogenous interleukin 33 enhances the brain’s lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice
Authors: Liu Mingqi , Huang Jinhao , Liu Tao , Yuan Jiangyuan , Lv Chuanxiang , Sha Zhuang , Wu Chenrui , Jiang Weiwei , Liu Xuanhui , Nie Meng , Chen Yupeng , Dong Shiying , Qian Yu , Gao Chuang , Fan Yibing , Wu Di , Jiang Rongcai 
Published: April 2023

AbstractThe persistent dysregulation and accumulation of poisonous proteins from destructive neural tissues and cells activate pathological mechanisms after traumatic brain injury (TBI). The lymphatic drainage system of the brain, composed of the glymphatic system and meningeal lymphatic vessels (MLVs), plays an essential role in the clearance of toxic waste after brain injury. The neuroprotective effect of interleukin 33 (IL-33) in TBI mice has been demonstrated; however, its impact on brain lymphatic drainage is unclear. Here, we established a fluid percussion injury model to examine the IL-33 administration effects on neurological function and lymphatic drainage in the acute brain of TBI mice. We verified that exogenous IL-33 could improve the motor and memory skills of TBI mice and demonstrated that in the acute phase, it increased the exchange of cerebrospinal and interstitial fluid, reversed the dysregulation and depolarization of aquaporin-4 in the cortex and hippocampus, improved the drainage of MLVs to deep cervical lymph nodes, and reduced tau accumulation and glial activation. We speculate that the protective effect of exogenous IL-33 on TBI mice’s motor and cognitive functions is related to the enhancement of brain lymphatic drainage and toxic metabolite clearance from the cortex and hippocampus in the acute stage. These data further support the notion that IL-33 therapy may be an effective treatment strategy for alleviating acute brain injury after TBI.
Cost of diabetes and its complications: results from a STEPS survey in Punjab, India
Authors: Kansra Pooja , Oberoi Sumit 
Published: April 2023

Abstract
Background
Diabetes mellitus is an obtrusive universal health emergency in developed and developing countries, including India. With the exponential rise of epidemiological conditions, the costs of treating and managing diabetes are on an upsurge. This study aimed to estimate the cost of diabetes and determine the determinants of the total cost among diabetic patients.

Methods
This cross-sectional study was executed in the northern state of Punjab, India. It involves the multi-stage area sampling technique and data was collected through a self-structured questionnaire adapted following the “WHO STEPS Surveillance” manual. Mann–Whitney U and Kruskal–Wallis tests were performed to compare the cost differences in socio-demographic variables. Lastly, multiple linear regression was conducted to determine and evaluate the association of the dependent variable with numerous influential determinants.

Results
The urban respondents' average direct and indirect costs are higher than rural respondents. Age manifests very eccentric results; the highest mean direct outpatient care expenditure of ₹52,104 was incurred by the respondents below 20 years of age. Gender, complications, income, history of diabetes and work status were statistically significant determinants of the total cost. Study reports a rapid increase in the median annual direct and indirect cost from ₹15,460 and ₹3572 in 1999 to ₹34,100 and ₹4200 in 2021.

Conclusions
The present study highlights that the economic jeopardy of diabetes can be managed by educating people about diabetes and its associated risk factors. The economic burden of diabetes could be restrained by formulating new health policies and promoting the use of generic medicines. The result of the study directs that expenditure on outpatient care is to be reimbursed under the ‘Ayushman Bharat-Sarbat Sehat Bima Yojana’.
Scientific and technological research on the use of wine lees
Authors: de Andrade Bulos Roberta Barreto , da Gama Paz Francine , Machado Ciro Gomes , Tavares Pedro Paulo Lordelo Guimarães , de Souza Carolina Oliveira , Umsza-Guez Marcelo Andrés 
Published: April 2023

Abstract
Background
Wine lees are defined as the residue formed at the bottom of the container during the wine fermentation stage. It consists of a solid phase composed of yeasts and bacteria responsible for vinification. In general, wine lees, despite being a material rich in polyphenols, are underused or discarded. In this context, the aim of this review is to present an overview of the use of wine lees in the food industry and other sectors, by means of scientific and technological surveys.

Methodology
Bibliographical searches of the main works published on wine lees or grapes were carried out in articles selected in the Scopus and SciELO databases, while the search for the technology protected or described in patent documents involving wine lees and their main applications was carried out through the Espacenet online database combined with the private platform from Questel company: Orbit®.

Main text
Wine lees represent an important fraction of winemaking by-products and contain several high-value components with potential to be exploited in industrial sectors, such as phenolic compounds. Through the Technological Prospection, it was demonstrated that wine lees are still poorly studied, with few patents filed on the technological/nutritional properties of wine lees. In 2016, there was a peak of patent filing growth and China was the country with the highest number of patents, totaling 31 deposits. Regarding the area of application, agriculture was the most common, followed by beverage production. Most of the inventors are of Asian origin, corroborating the results previously discussed regarding the distribution of patents per country, and this might probably be related to the high investment of these countries in various stages of education and technological research.

Conclusion
The study suggests that different applications should aim at developing an integrated approach aimed at extracting from wine lees the highest number and quantities of compounds with possible applications in different sectors.

Graphical Abstract
Aortic stenosis: a review on acquired pathogenesis and ominous combination with diabetes mellitus
Authors: Wal Pranay , Rathore Shruti , Aziz Namra , Singh Yash Kumar , Gupta Arpit 
Published: April 2023

Abstract
Background
Aortic stenosis (AS) is a progressive disease, with no pharmacological treatment. The prevalence of diabetes mellitus (DM) among AS patients is higher than in the general population. DM significantly increases the risk of AS development and progression from mild to severe. The interplay between AS and DM's mechanism is not entirely known yet.

Main Body
The increased accumulation of advanced glycation end products (AGEs) was linked to increased valvular oxidative stress, inflammation, expression of coagulation factors, and signs of calcification, according to an analysis of aortic stenotic valves. It is interesting to note that in diabetic AS patients, valvular inflammation did not correlate with serum glucose levels but rather only with long-term glycemic management markers like glycated haemoglobin and fructosamine. Transcatheter aortic valve replacement, which has been shown to be safer than surgical aortic valve replacement, is advantageous for AS patients who also have concurrent diabetes. Additionally, novel anti-diabetic medications have been proposed to lower the risk of AS development in DM patients, including sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonist that target reduction of AGEs-mediated oxidative stress.

Conclusions
There are little data on the effects of hyperglycemia on valvular calcification, but understanding the interactions between them is essential to develop a successful treatment strategy to stop or at least slow the progression of AS in DM patients. There is a link among AS and DM and that DM negatively impacts the quality of life and longevity of AS patients. The sole successful treatment, despite ongoing efforts to find new therapeutic modalities, involves aortic valve replacement. More research is required to find methods that can slow the advancement of these conditions, enhancing the prognosis and course of people with AS and DM.

Graphical Abstract
Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications
Authors: Zhou Lifang , Yao Shaohua 
Published: April 2023

AbstractRecently, clustered regularly interspaced palindromic repeats (CRISPR)-Cas9 derived editing tools had significantly improved our ability to make desired changes in the genome. Wild-type Cas9 protein recognizes the target genomic loci and induced local double strand breaks (DSBs) in the guidance of small RNA molecule. In mammalian cells, the DSBs are mainly repaired by endogenous non-homologous end joining (NHEJ) pathway, which is error prone and results in the formation of indels. The indels can be harnessed to interrupt gene coding sequences or regulation elements. The DSBs can also be fixed by homology directed repair (HDR) pathway to introduce desired changes, such as base substitution and fragment insertion, when proper donor templates are provided, albeit in a less efficient manner. Besides making DSBs, Cas9 protein can be mutated to serve as a DNA binding platform to recruit functional modulators to the target loci, performing local transcriptional regulation, epigenetic remolding, base editing or prime editing. These Cas9 derived editing tools, especially base editors and prime editors, can introduce precise changes into the target loci at a single-base resolution and in an efficient and irreversible manner. Such features make these editing tools very promising for therapeutic applications. This review focuses on the evolution and mechanisms of CRISPR-Cas9 derived editing tools and their applications in the field of gene therapy.
Tumor-Naïve Circulating Tumor DNA as an Early Response Biomarker for Patients Treated With Immunotherapy in Early Phase Clinical Trials
Authors: Sanz-Garcia Enrique , Genta Sofia , Chen Xiaoxi , Ou Qiuxiang , Araujo Daniel V. , Abdul Razak Albiruni R. , Hansen Aaron R. , Spreafico Anna , Bao Hua , Wu Xue , Siu Lillian L. , Bedard Philippe L. 
Published: April 2023

PURPOSE To evaluate early circulating tumor DNA (ctDNA) kinetics using a tumor-naïve assay and correlate it with clinical outcomes in early phase immunotherapy (IO) trials. METHODS Plasma samples were analyzed using a 425-gene next-generation sequencing panel at baseline and before cycle 2 (3-4 weeks) in patients with advanced solid tumors treated with investigational IO agents. Variant allele frequency (VAF) for mutations in each gene, mean VAF (mVAF) from all mutations, and change in mVAF between both time points were calculated. Hyperprogression (HyperPD) was measured using Matos and Caramella criteria. RESULTS A total of 162 plasma samples were collected from 81 patients with 27 different tumor types. Patients were treated in 37 different IO phase I/II trials, 72% of which involved a PD-1/PD-L1 inhibitor. ctDNA was detected in 122 plasma samples (75.3%). A decrease in mVAF from baseline to precycle 2 was observed in 24 patients (37.5%) and was associated with longer progression-free survival (hazard ratio [HR], 0.43; 95% CI, 0.24 to 0.77; P < .01) and overall survival (HR, 0.54; 95% CI, 0.3 to 0.96; P = .03) compared with an increase. These differences were more marked if there was a >50% decrease in mVAF for both progression-free survival (HR, 0.29; 95% CI, 0.13 to 0.62; P < .001) and overall survival (HR, 0.23; 95% CI, 0.09 to 0.6; P = .001). No differences in mVAF changes were observed between the HyperPD and progressive disease patients. CONCLUSION A decrease in ctDNA within 4 weeks of treatment was associated with treatment outcomes in patients in early phase IO trials. Tumor-naïve ctDNA assays may be useful for identifying early treatment benefits in phase I/II IO trials.
THE CHALLENGE OF THE EMERGENCY REMOTE TEACHING IN THE EDUCATION OF ART CONSERVATORS. EXPERIENCES AND REFLECTIONS
Authors: Alexopoulou Athena 
Published: April 2023

COVID-19 pandemic and the measures to constrain it have influenced, among others, every dimension of the cultural heritage; from research, conservation and preservation projects to training and education. The closure of training buildings and campuses, the cancellation of face-to-face classes and labs and other learning experiences forced a shift to emergency remote teaching. Especially, for art conservators education, as the field of heritage conservation is powered by art history, technology and science, any deceleration has an important impact on it. Moreover, conservators have to be in contact with the real object, to be present physically in the archaeological sites, to interact with the material of the monuments and traditionally they work very close to them. The closure of the education domain deprived conservation students from the physical contact with the objects, but had fostered the digital transformation of the heritage sector, as well as the academic conservation education. The goal of this paper is to discuss advantages and weaknesses of emergency remote teaching comparing to face-to-face teaching and online teaching too, as well as to record the experience of the remote teaching in the Department of Conservation of Antiquities and Artworks and the opportunities emerged for the curricula of the Department.
SENSING THE PAST: AN EXPLORATION OF ART AND ARCHAEOLOGY
Authors: Poraj-Wilczynska Elizabeth 
Published: April 2023

This portfolio deals with the work I have been undertaking for the past 20 years. Investigating sense of place at Belas Knap Neolithic long barrow, Cotswolds, England. I have taken an holistic approach in the creation of art that aims to bridge the sensory experience of archaeology, memory and culture. Over the last twenty years I have been responding through my art to place and memory, mapping, interpreting and connecting to the seasonal changes at Belas Knap, a laterally chambered Neolithic long barrow located in the Cotswold Hills, Gloucestershire, South West England (NGR: SP0209 2554).
FROM CAMERA AS PART OF THE BODY, TO CAMERA – THE BODY PART
Authors: Dimitrijevič Danica 
Published: April 2023

The digital world is where 3.4 billion people communicate via digital images through social media. On average, each one of us spends 6 hours each day in front of a screen. The digital images rapidly appearing and disappearing under our scrolling fingers shape our perception, time and body movements, brain structure, and responses in a complex neurological way. The camera enables the formation of our identity, social development, aesthetic value, and cultural participation. Without this camera image, one is isolated, unable to speak. Moreover, without storage where we save images, we are exempt from personal history, narratives, and memory. Once we integrated a camera into the smartphone, we produced an extra organ. With the Orion visual cortical prosthesis medical study that implants a camera into the eyes to restore vision, face emotional surveillance project VibeCheck, and BeAnotherLab software, swooping through virtual reality the bodies, this article follows the socio-philosophical and technological shifts through the history of the camera and photography in object production, body perception, their definition, interaction, and final merge between body and camera object. Through the reference of the theoretical works of Roland Barthes, Maurice Merleau-Ponty, Karen Barad and Tim Ingold, the article follows how we have produced camera images through time and how camera images have been producing us. The camera transforms from a separate room or device to a prosthetic/inherent part of the body, without which the body is not fully functional. Today, a person without a phone camera is marginalized and handicapped. The deficit of not having an image-generating tool turns out to be a sensual deprivation, social limitation and discrepancy in identity.
BEAUTY IS…
Authors: Lasithiotaki Nina 
Published: April 2023

Walter Benjamin aptly describes the dual role of photography, since its invention, saying that “photography stakes a claim to art as soon as it appears as a commodity”. Although fashion has become the subject of significant philosophical and sociological study over the past 150 years, it continues to be a taboo, or merely too lowly a subject for academic consideration – even in modern–day cultural studies. The reason is clear: fashion does not pose an argument; it entices and seduces, constantly looking for a new aesthetic paradigm that will embody the eternal polytheism of Beauty. Photographer Julia Hetta adopts many of the tools and practices of classical painting to capture the paradox and ambiguity of the concept of Beauty, which Victor Hugo likens to Death, noting that: “Death and beauty are two things profound, so of dark and azure, that one might say that they were two sisters terrible and fecund, possessing the one enigma, the one secret.” Hetta illustrates the dualism of the modernist subject with appeals to the imaginary of an insurmountable innocence and purity, as this is captured in depictions of the classical ideal; and precisely therein lies the originality of her gaze. She develops a personal style in photography, featuring strong elements of drama and theatrics. She illustrates the current, the innovative, the radical in the field of human presence and clothing, recalling the cultural deposits of times past, but also imbuing her creations with new rules that detect a subjective and complex beauty.
PROJECT SPINOZA: RE/MEMBERING SENSORIAL COGENCY - (Part two)
Authors: Barth Theodor 
Published: April 2023

The purpose of this article is to present a research portfolio – composed of an online archive and an index from 2020-22 – and perform its outcomes in a memory-theatre. The design needed for this theatre is modelled on Baruch Spinoza’s Ethica, in which the order of a geometrical demonstration hosts a philosophical investigation. The non-same rules/ heteronomy of the host and the guest, in Spinoza’s opus magnum, is an instance of a wider phenomenon which the article seeks to explore and exploit: the docking of an investigation, by the means of a contraption that is foreign to it, intercepting images of what the present may have in store (whether past, present, or future). The sensorial cogency that picks up on elements it can comprehend, but never fully contain: the mnemonic slippery nature of the image. On this backdrop, the article discusses different ways of pairing up with the environment, through media that are hosted rather than belonging there: the different terms of populating the present, being together or forming a group, serve to elucidate certain aspects of memory – mnemonic devices with an environmental footprint – in fieldwork, laboratory research, digital culture or presently the electrosphere. The article thereby seeks to develop and propose some designs to work with the problem of interception – picking up changes in the ‘memory of the present’ (Bergson, 2021): what it holds and what it has in store. The article seeks to establish a parity between apparatuses with such impact, in view of comparing them: whether they are as simple as 1) a post in a hole (a datum), or more complex as 2) a computer docked to a home-office (another datum). In the presentation of the portfolio, a framework for partaking of such changes, compiling the experience prompted by them, is proposed (Benjamin, 1999). The major feature of this framework is then deepened in a situated case-study: here, positions coexisting and valued on different terms, in the presence of a cabin in reconstruction, shift as they are logged in a guest book. In a section on design, the article probes a broader applicability of what has been found in the case-study, based on a wider fieldwork experience. Principle: repair also writes re-pair. In the conclusion, a design for a ‘contemporary interception’ is demonstrated visually. The anthroponomical framework is conceived as a scholarly contribution to art, and an artistic contribution to science, through a mnemonic understanding of the technical image.