bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and verification of feature biomarkers associated in heart failure by bioinformatics analysis
Authors: Yu Yi-ding , Xue Yi-tao , Li Yan 
Published: March 2023

AbstractHeart failure is the final destination of most cardiovascular diseases, and its complex molecular mechanisms remain largely uncertain. This study aimed to systematically investigate the underlying molecular mechanisms and diagnostic and therapeutic targets of heart failure using bioinformatics. We obtained 8 healthy samples and 8 heart failure samples from GSE8331 and GSE76701. After removing the batch effect, we performed a differential analysis on it and obtained 185 differentially expressed ID. The results of enrichment analysis showed that the molecular mechanisms of heart failure were mostly related to immune, inflammation, and metabolism-related pathways. Immune cell infiltration analysis showed that the degree of infiltration of Tgd cells and Neurons was significantly enriched in heart failure samples, whereas pDCs and NKTs were in healthy tissue samples. We obtained Hub genes including EGR1, EGR2, FOS and FOSB by PPI network analysis. We established a 4-gene diagnostic model with Hub gene, and validated it in GSE21610 and GSE57338, and evaluated the discriminative ability of Hub gene by ROC curve. The 4-gene diagnostic model has an AUC value of 0.775 in GSE21610 and 0.877 in GSE57338. In conclusion, we explored the underlying molecular mechanisms of heart failure and the immune cell infiltration environment of failing myocardium by performing bioinformatic analysis of the GEO dataset. In addition, we identified EGR1, EGR2, FOS and FOSB as potential diagnostic biomarkers and therapeutic targets for heart failure. More importantly, a diagnostic model of heart failure based on these 4 genes was developed, which leads to a new understanding of the pathogenesis of heart failure and may be an interesting target for future in-depth research.
Significant, but not biologically relevant: Nosema ceranae infections and winter losses of honey bee colonies
Authors: Schüler Vivian , Liu Yuk-Chien , Gisder Sebastian , Horchler Lennart , Groth Detlef , Genersch Elke 
Published: March 2023

AbstractThe Western honey bee Apis mellifera, which provides about 90% of commercial pollination, is under threat from diverse abiotic and biotic factors. The ectoparasitic mite Varroa destructor vectoring deformed wing virus (DWV) has been identified as the main biotic contributor to honey bee colony losses worldwide, while the role of the microsporidium Nosema ceranae is still controversially discussed. In an attempt to solve this controversy, we statistically analyzed a unique data set on honey bee colony health collected from a cohort of honey bee colonies over 15 years and comprising more than 3000 data sets on mite infestation levels, Nosema spp. infections, and winter losses. Multivariate statistical analysis confirms that V. destructor is the major cause of colony winter losses. Although N. ceranae infections are also statistically significantly correlated with colony losses, determination of the effect size reveals that N. ceranae infections are of no or low biological relevance.
Measurements of quarkonium production and polarization in Pb–Pb collisions with ALICE
Authors: Bai Xiaozhi 
Published: March 2023

Quarkonia are excellent probes of deconfinement in heavy-ion collisions. For J/ψ, a bound state of cc¯ quarks, the (re-)generation is found to be the dominant production mechanism at the LHC energies. Production measurements of non-prompt J/ψ, originating from beauty-hadron decays, allow one to access the interaction of beauty-quarks with the quark-gluon plasma (QGP). Polarization and spin alignment measurements can be used to investigate the characteristics of the formed medium. Moreover, it has been hypothesized that quarkonium states can be polarized by the strong magnetic field generated in the initial state of the collision and by the large angular momentum of the medium in non-central heavy-ion collisions.
In these proceedings, the measurements of the inclusive, prompt, and non-prompt J/ψ nuclear modification factor RAA in Pb–Pb collisions at √SNN = 5.02 TeV are shown. The measured non-prompt J/ψ fraction extends down to very low pT with a significantly improved precision compared to previous publications. The results from the first publication on the J/ψ polarization with respect to the event-plane in Pb–Pb collisions at √SNN = 5.02 TeV at forward rapidity are presented as well. The results are compared with available calculations.
Results on system size dependence of strangeness production in the CERN SPS energy range from NA61/SHINE
Authors: Podlaski Piotr 
Published: March 2023

NA61/SHINE is a multipurpose fixed-target facility at the CERN Super Proton Synchrotron. The main goals of the NA61/SHINE strong interactions program are to discover the critical point of strongly interacting matter and study the properties of the onset of deconfinement. To reach these goals, hadron production measurements are performed in the form of a two-dimensional scan by varying collision energy and system size. The Collaboration has recently finished data acquisition for its original program on strong interactions, accumulating broad data samples on hadron production in various systems in the SPS energy range.
In this contribution, the NA61/SHINE results on identified charged kaon and pion production in p+p, Be+Be and Ar+Sc collisions at the SPS energy range (√SNN = 5.1 - 17.3 GeV) are presented. The NA61/SHINE measurements of small and intermediate-mass ion collisions establish an interesting system size dependence, showing a rapid change of hadron production properties that starts when moving from Be+Be to Ar+Sc system. In particular, Ar+Sc is the smallest system for which a significant enhancement of K+/π+ ratio with respect to p+p collisions is observed. Obtained energy and system size dependence of the measured charged hadron multiplicities are compared with available world data and various theoretical models.
Myocardial Evaluation in Patients with Aortic Stenosis by Cardiac Computed Tomography
Authors: Gama Francisco F. , Patel Kush , Bennett Jonathan , Aziminia Nikoo , Pugliese Francesca , Treibel Thomas 
Published: March 2023

Background Aortic valve stenosis (AVS) is one of the most prevalent pathologies affecting the heart that can curtail expected survival and quality of life if not managed appropriately.
Current Status Cardiac computed tomography (CT) has long played a central role in this subset, mostly for severity assessment and for procedural planning. Although not as widely accepted as other imaging modalities for functional myocardial assessment [i. e., transthoracic echocardiogram (TTE), cardiac magnetic resonance (CMR)], this technique has recently increased its clinical application in this regard.
Future Outlook The ability to provide morphological, functional, tissue, and preprocedural information highlights the potential of the “all-in-one” concept of cardiac CT as a potential reality for the near future for AVS assessment. In this review article, we sought to analyze the current applications of cardiac CT that allow a full comprehensive evaluation of aortic valve disease.
Key Points:
Citation Format
The Effectiveness Of Trigger Point Treatment In Chronic Pelvic Pain;
A Pilot Randomised Controlled Trial
Authors: Atas Kubra , Mutlu Ebru Kaya , Yasa Cenk , Ugurlucan Funda Gungor 
Published: March 2023

Abstract
Objective To investigate the effectiveness of ischemic compression and
low-level laser therapy methods combined with exercise on the myofascial trigger
points in women with Chronic Pelvic Pain and to determine which method is more
effective.
Methods It was a parallel designed, single-blind pilot randomized clinical
trial. Patients were recruited at physiotherapy laboratory of the Istanbul
University from September 2017 to June 2019. Twenty-eight women patients with
Chronic Pelvic Pain were included into the trial. Patients were randomized into
two groups. Group 1 received ischemic compression and Group 2 received low-level
laser therapy twice a week for 6 weeks. Both groups received the same standard
exercise program. Pain, range of motion, pelvic floor symptom severity, quality
of life, satisfaction, anxiety, and depression were assessed after 6 weeks, and
1-year follow up.
Results Following the treatment, significant differences were observed
within both group subjects in pain, range of motion, symptom severity, quality
of life, and anxiety-depression (p<0.05). This significant improvement
in pain, symptom severity, symptoms related quality of life and pain subgroup of
Short Form 36, continued after 1-year follow up (p<0.05). In comparison
between group, Group 1 have more significant improvement than Group 2 in terms
of symptoms related quality of life (p<0.05).
Conclusion Both methods have shown efficacy and can be used safely in
chronic pelvic pain patients. Because it is more effective on symptoms related
quality of life, the ıschemic compression method may be preferred for
primary use.
Radiologic Evolution after Scapholunate Dorsal Capsulodesis for Chronic Tears
Authors: Borrel François , Gras Mathilde , Arnaout Ahlam , Mathoulin Christophe , Merlini Lorenzo 
Published: March 2023

Abstract
Background Many debates are still ongoing for the management of chronic scapholunate (SL) injuries. We have proposed an arthroscopic technique of dorsal capsulodesis with good clinical results. We now propose a radiological follow-up.
Purpose To determine if arthroscopic dorsal capsulodesis can improve the radiographic SL angle and maintain this correction over time.
Methods From January 2020 to January 2021, we included every patient with an SL instability and sorted them according to the European Wrist Arthroscopy Society (EWAS) classification. All patients had bilateral X-rays with a measurement of the radiolunate (RL) and SL angles for both the pathologic and healthy side. We also included patients with lunotriquetral or triangular fibrocartilage complex lesions. The exclusion criteria were the presence of arthritis and persistent intraoperative SL instability after capsulodesis. An arthroscopic dorsal capsulodesis was performed in all patients as originally described by Mathoulin. The RL and SL angles were then again measured on the immediate postoperative X-ray, and then again at 3, 6, and 12 months postoperatively. The statistical analysis was done using a paired Student's t-test with 145 degrees of freedom and α = 0.05.
Results We included a total of 146 patients with a 1-year follow-up. Both the RL angle and the SL angles approach the healthy side at 12 months postoperatively. The RL angle has increased from −7.23 degrees to 4.37 degrees; the difference is still statistically significative, but it is almost equal to the healthy side (5.16 degrees). The SL angle has lowered from 74.55 to 54.95; the difference is still statistically and radiologically significative (6.788 degrees) but has been lowered by 74.3%.
Conclusion This study shows that this technique can normalize the dorsal intercalated segment instability (DISI) over time without the need for any pinning or invasive ligament reconstructive surgery.
Level of Evidence Level IV, cohort study.
Clinical Relevance Dorsal capsulodesis should be considered in all reducible SL injuries, even when DISI is present.
Synthesis and characterization of bismuth ferrite particles using a nano-agitator bead mill
Authors: Smith Lyndon , Shield Jeffrey , Ahmadi Zahra , Jeelani Shaik , Rangari Vijaya 
Published: March 2023

Bismuth ferrite (BiFeO3) nanocomposites were synthesized using a novel nano-agitator bead milling method followed by calcination. Bismuth oxide and iron oxide nanoparticles were mixed in a stoichiometric ratio and milled for 3 h and calcined at 650 °C in air. X-ray diffraction with Rietveld refinement, scanning electron microscopy, and transmission electron microscopy techniques were used to elucidate the structure of BiFeO3. The particle diameter was found to be ∼17 nm. Magnetic and electrical measurements were performed, and these results were compared with those of similar methods. Mostly, BiFeO3 was obtained with minor secondary phase formation. The resulting powder was weakly ferromagnetic with a remnant magnetization of 0.078 emu/g. This can be attributed to residual strain and defects introduced during the milling process. Electrical testing revealed a high leakage current density that is typical of undoped bismuth ferrite.
Determining the impact of gold nanoparticles on amyloid aggregation with 2D IR spectroscopy
Authors: Hess Kayla A. , Spear Nathan J. , Vogelsang Sophia A. , Macdonald Janet E. , Buchanan Lauren E. 
Published: March 2023

As nanomaterials become more prevalent in both industry and medicine, it is crucial to fully understand their health risks. One area of concern is the interaction of nanoparticles with proteins, including their ability to modulate the uncontrolled aggregation of amyloid proteins associated with diseases, such as Alzheimer’s disease and type II diabetes, and potentially extend the lifetime of cytotoxic soluble oligomers. This work demonstrates that two-dimensional infrared spectroscopy and 13C18O isotope labeling can be used to follow the aggregation of human islet amyloid polypeptide (hIAPP) in the presence of gold nanoparticles (AuNPs) with single-residue structural resolution. 60 nm AuNPs were found to inhibit hIAPP, tripling the aggregation time. Furthermore, calculating the actual transition dipole strength of the backbone amide I’ mode reveals that hIAPP forms a more ordered aggregate structure in the presence of AuNPs. Ultimately, such studies can provide insight into how mechanisms of amyloid aggregation are altered in the presence of nanoparticles, furthering our understanding of protein–nanoparticle interactions.
Fine-grained transfer learning based on deep feature decomposition for rotating equipment fault diagnosis
Authors: Dong Jingchuan , Su Depeng , Gao Yubo , Wu Xiaoxin , Jiang Hongyu , Chen Tao 
Published: March 2023

Abstract
The study of transfer learning in rotating equipment fault diagnosis helps overcome the problem of low sample marker data and accelerates the practical application of diagnostic algorithms. Previously reported methods still require numerous fault data samples; however, it is unrealistic to obtain information about the different health states of rotating equipment under all operating conditions. In this paper, a two-stage, fine-grained, fault diagnosis framework is proposed for implementing fault diagnosis across domains of rotating equipment under the condition of no target domain data. Considering that the target domain is completely unknown, the main idea of this paper is to decompose multiple source domain depth features to identify domain-invariant categorical features common under different source domains and classify unknown target domains. More impressively, the problems of data imbalance and low signal-to-noise ratio can be properly solved in our network. Extensive experiments are conducted in two different case studies of rotating devices to validate the proposed method. The experiments show that the method in this paper achieves significant results on both bearing and gearbox health status classification tasks, outperforming other deep transfer learning methods.
Hydrogenated cove-edge aluminum nitride nanoribbons for ultrascaled resonant tunneling diode applications: a computational DFT study
Authors: Kharwar Saurabh , Singh Sangeeta , Kaushik Brajesh Kumar 
Published: March 2023

Abstract
While synthesizing quasi-one-dimensional nanoribbons, there is a finite probability that edges have cove-edge defects. This paper focuses on the structural, electronic, and transport properties of cove-edge aluminum nitride nanoribbons (AlNNR) using density functional theory and the non-equilibrium Green’s function (NEGF) method. The cove-edge AlNNRs are thermodynamically stable and exhibit metallic behavior. Interestingly, the calculated current–voltage characteristics of the cove-edge AlNNR-based nanodevices show negative differential resistance (NDR). The H-AlN-Cove nanodevice exhibits high peak-to-valley current ratio (PVCR) of the order of 107. The calculated PVCR of the H-AlN-Cove nanodevice is 106 times higher than that of the silicene nanoribbon (SiNR) and graphene nanoribbon (GNR), and 104 times higher than that of the phosphorene nanoribbon (PNR) and arsenene nanoribbons (ANR)-based devices respectively. The NDR feature with high PVCR provides a prospect for the cove-edge AlNNR in nanodevice applications.
CuSCN/Si heterojunction near-infrared photodetector based on micro/nano light-trapping structure
Authors: Liu Biao , Shen Honglie , Zhang Jingzhe , Chen Dewen , Mao Weibiao 
Published: March 2023

Abstract
In this paper, high-performance CuSCN/Si heterojunction near-infrared photodetectors were successfully prepared using nanoscale light-trapping optical structures. Various light-trapping structures of ortho-pyramids, inverted pyramids and silicon nanowires were prepared on silicon substrates. Then, CuSCN films were spin-coated on silicon substrates with high crystalline properties for the assembly of CuSCN/Si photodetectors. Their reflectance spectra and interfacial passivation properties were characterized, demonstrating their superiority of light-trapping structures in high light response. Under the irradiation of 980 nm near-infrared light, a maximum responsivity of 2.88 A W−1 at −4 V bias and a specific detectivity of 5.427 × 1010 Jones were obtained in the CuSCN/Si heterojunction photodetectors prepared on planner silicon due to 3.6 eV band gap of CuSCN. The substrates of the light-trapping structure were then applied to the CuSCN/Si heterojunction photodetectors. A maximum responsivity of 10.16 A W−1 and a maximum specific detectivity of 1.001 × 1011 Jones were achieved under the 980 nm near-infrared light irradiation and −4 V bias, demonstrating the advanced performance of CuSCN/Si heterojunction photodetectors with micro-nano light-trapping substrates in the field of near-infrared photodetection compared to other silicon-based photodetectors.
Ferromagnetic and metamagnetic transitions in itinerant electron systems: a microscopic study
Authors: Yamase Hiroyuki 
Published: March 2023

Abstract
We perform a microscopic study of itinerant ferromagnetic systems. We reveal a very rich phase diagram in the three-dimensional space spanned by the chemical potential, a magnetic field, and temperature beyond the Landau theory analyzed so far. Besides a generic wing structure near a tricritical point upon introducing the magnetic field, we find that an additional wing can be generated close to a quantum critical end point (QCEP) and also even from deeply inside the ferromagnetic phase. A tilting of the wing controls the entropy jump associated with the metamagnetic transition. Ferromagnetic and metamagnetic transitions are usually accompanied by a Lifshitz transition at low temperatures, i.e. a change of Fermi surface topology including the disappearance of the Fermi surface. In particular, the Fermi surface of either spin band vanishes at the QCEP. These rich phase diagrams are understood in terms of the density of states and the breaking of particle-hole symmetry in the presence of a next nearest-neighbor-hopping integral tʹ, which is expected in actual materials. The obtained phase diagrams are discussed in a possible connection to itinerant ferromagnetic systems such as UGe2, UCoAl, ZrZn2, and others including materials exhibiting the magnetocaloric effect.
Observational constraints on warm natural inflation
Authors: Montefalcone Gabriele , Aragam Vikas , Visinelli Luca , Freese Katherine 
Published: March 2023

Abstract
Warm natural inflation is studied for the case of the original cosine potential. The
radiation bath during inflation induces a dissipation (friction) rate in the equation of motion
for the inflaton field, which can potentially reduce the field excursion needed for an
observationally viable period of inflation. We examine if the dissipation thus provides a
mechanism to avoid the large decay constant f ≳ M
pl of cold cosine natural
inflation. Whereas temperature independent dissipation has previously been shown to alleviate the
need for a trans-Planckian decay constant f, we illustrate here the difficulties of
accommodating a significantly sub-Planckian decay constant (f < 10-1
M
pl) for the
case of a temperature dependent dissipation rate in the form Γ ∝ Tc
, with
c = {1,3}. Such dissipation rates represent physically well-motivated constructions in the
literature. For each model, we map its location in the r-ns
plane and compare with cosmic
microwave background (CMB) data. For c = 1 (c = 3), we find that agreement with CMB data requires
that dissipation be in the weak (moderate) regime and that the minimum allowed value of the decay
constant in the potential is f
min = 0.3 (0.8) M
pl, respectively.
Extraction energy from charged Vaidya black hole via the Penrose process
Authors: Vertogradov Vitalii 
Published: March 2023

AbstractIn this paper, we consider the analogy of the Penrose process in charged Vaidya spacetime. We calculate the border of the generalized ergosphere, in which the charged particles with negative energy might exist, and show that it is temporary. We show that there are no closed orbits for particles with negative energy inside the generalized ergosphere. We investigate the question about the efficiency of the Penrose process and show that one cannot extract large energies from a black hole if the velocities of ingoing and outgoing particles are of the same order. In the case of the extremal black hole, we show that the upper limit is restricted by the absolute value of the electric charge per mass.
Mass spectra of doubly heavy tetraquarks in diquark−antidiquark picture*
Authors: Song Yong-Xing , Jia Duo-Jie 
Published: March 2023

Abstract
Inspired by the recent observation of the first doubly charmed tetraquark T

cc
, we apply the linear Regge relation and mass scaling to study low-lying mass spectra of the doubly heavy tetraquark in a heavy-diquark−light-antidiquark picture. The measured data and other compatible estimates of ground-state masses of doubly heavy baryons are employed to evaluate masses of heavy diquark M

QQ
(Q = c, b) and the D/D

s
meson masses are used in mass scaling to determine the hyperfine mass splitting. Our mass computation indicates that all low-lying states of doubly heavy tetraquarks are unstable against strong decays to two heavy-light mesons, except for the ground states of nonstrange bb tetraquarks.
Development and application of absorbed dose primary standard for 60Co and high-energy photon beams using water calorimetry
Authors: Wang Zhipeng , Wang Kun , Jin Sunjun , Wang Feifei , Zhang Xi , Liu Fubin , Yao Jintao , Huang Ji , Qi Yaping , Zhang Jian 
Published: March 2023

Abstract
Several new glass vessels, thermistor probes, and water phantoms have been designed and built at the National Institute of Metrology (China) to upgrade and develop the existing water calorimeter. The increased plane-parallel vessels have shorter thermal stability times and shallower positioning depths (∼1.3 cm) than the previous cylindrical vessels, which makes them suitable for electron beams. The sensitivity of the new probes is 10% greater than the previous ones. In this study, detailed experimental and theoretical investigations of various factors affecting the new water calorimeter are performed. The system uncertainty of the water calorimeter is reduced and the robustness of the determination of the absorbed-dose-to-water D
w is improved using a variety of geometric detector vessels and two kinds of high-purity water systems saturated with high-purity gases. This new calorimeter is employed as a primary standard for determining the D
w, has achieved a combined standard uncertainty of 0.24% for a 60Co beam, 0.27% for 6 MV and 10 MV photon beams and 0.30% for a 25 MV photon beam. The beam quality conversion factors kQ
of ten cylindrical and three plane-parallel ionization chambers are measured using the new calorimeter to improve the reference dosimetry accuracy of high-energy clinical photon beams.