bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived barriers to maintain physical activity and its association to mental health status of Bangladeshi adults: a quantile regression approach
Authors: Hasan A. B. M. Nahid , Sharif Azaz Bin , Jahan Ishrat 
Published: June 2023

AbstractInsufficient physical activity and unhealthy lifestyle preferences have been significant concerns for decades. This study aimed to determine the perceived barriers to maintaining physical activity among adults in three major cities of Bangladesh and their association with mental health status. This is a cross-sectional study where 400 participants were selected using a multistage sampling technique. Twenty municipal wards were randomly selected from three cities, followed by a convenient selection of the study participants from each ward. Questionnaires about perceived physical activity barriers were developed based on previously published literature. The DASS-21 scale assessed the mental health status of the study participants. Descriptive statistics were applied to narrate the baseline characteristics of the respondents. The Shapiro–Wilk test was used to check the normality of the perceived physical activity scores. Quantile regression analysis was applied to model the physical activity barrier scores depending on several covariates. Five quantiles were used: the 10th, 25th, 50th, 75th, and 90th. A p-value less than 0.05 was considered significant for hypothesis testing. Among the respondents, 68.50% were male, half of them were married, 68.0% belonged to nuclear families, 48.0% completed graduate level education, 34.25% were service holders, one-third of the respondent's working hours were 6–8 h, and 19.50% belongs to the overweight and obese groups. Poor traffic and construction work near the road (60.30%) was seen as the most significant barrier to physical activity. Over half of the respondents stated that lack of time, facilities, and expenses hinder physical activity. Mental health status reported mild to extremely severe levels of depression (32%), anxiety (47%), and stress (42.50%), respectively. Significant associations between the perceived physical activity scores and gender, family type, occupation, income, BMI, anxiety, and depression were obtained. Ensuring a safe environment, facilitating accessibility and availability of low-cost exercise facilities, improving road and traffic conditions, and providing appropriate mental health counseling may help to mitigate physical activity barriers.
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome
Authors: Portales-Castillo Ignacio , Dean Thomas , Cheloha Ross W. , Creemer Brendan A. , Vilardaga Jean-Pierre , Savransky Sofya , Khatri Ashok , Jüppner Harald , Gardella Thomas J. 
Published: June 2023

AbstractThe parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that plays key roles in regulating calcium homeostasis and skeletal development via binding the ligands, PTH and PTH-related protein (PTHrP), respectively. Eiken syndrome is a rare disease of delayed bone mineralization caused by homozygous PTH1R mutations. Of the three mutations identified so far, R485X, truncates the PTH1R C-terminal tail, while E35K and Y134S alter residues in the receptor’s amino-terminal extracellular domain. Here, using a variety of cell-based assays, we show that R485X increases the receptor’s basal rate of cAMP signaling and decreases its capacity to recruit β-arrestin2 upon ligand stimulation. The E35K and Y134S mutations each weaken the binding of PTHrP leading to impaired β-arrestin2 recruitment and desensitization of cAMP signaling response to PTHrP but not PTH. Our findings support a critical role for interaction with β-arrestin in the mechanism by which the PTH1R regulates bone formation.
NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism
Authors: Okada Nobuhiro , Ueki Chihiro , Shimazaki Masahiro , Tsujimoto Goki , Kohno Susumu , Muranaka Hayato , Yoshikawa Kiyotsugu , Takahashi Chiaki 
Published: June 2023

AbstractTwo splicing variants exist in NFYA that exhibit high expression in many human tumour types. The balance in their expression correlates with prognosis in breast cancer, but functional differences remain unclear. Here, we demonstrate that NFYAv1, a long-form variant, upregulates the transcription of essential lipogenic enzymes ACACA and FASN to enhance the malignant behavior of triple-negative breast cancer (TNBC). Loss of the NFYAv1-lipogenesis axis strongly suppresses malignant behavior in vitro and in vivo, indicating that the NFYAv1-lipogenesis axis is essential for TNBC malignant behavior and that the axis might be a potential therapeutic target for TNBC. Furthermore, mice deficient in lipogenic enzymes, such as Acly, Acaca, and Fasn, exhibit embryonic lethality; however, Nfyav1-deficient mice exhibited no apparent developmental abnormalities. Our results indicate that the NFYAv1-lipogenesis axis has tumour-promoting effects and that NFYAv1 may be a safe therapeutic target for TNBC.
Second harmonic generation from symmetry breaking stimulated by mixed organic cations in zero-dimensional hybrid metal halides
Authors: Cao Jindong , Liu Kunjie , Quan Mingzhen , Hou An , Jiang Xingxing , Lin Zheshuai , Zhao Jing , Liu Quanlin 
Published: June 2023

(C9N3H15)(C9H13SO)MBr6 (M = Bi/Sb) with mixed organic cations crystallizes in the orthorhombic system of the polar space group P212121. Phase-matchable SHG of the title compounds is 1.8 and 1.7 × KH2PO4 in the size range of 300–425 μm, respectively.
A Comparison of Maternal and Clinician Perception of Communication in Autistic Toddlers
Authors: Stern Yael S. , Lee Jordan , Levy Rachel , Glickman Alana , Grauzer Jeffrey , Kaat Aaron J. , Roberts Megan Y. 
Published: June 2023

Purpose:
Parent instruction in communication facilitation strategies for autistic toddlers relies on assumptions that parents interpret child behaviors in alignment with clinician definitions of communication. The purpose of this study was to identify features of child behaviors that are predictive of alignment in identification of child communication between clinical researchers and mothers of young autistic children.

Method:
Participants were 33 mothers and their autistic children between 18 and 48 months of age. Mothers' and clinical researchers' perceptions of child communication were assessed using a procedure in which mothers and clinical researchers each independently identified child communication in the same ten 1-min video clips of each mother's child. Endorsed communicative acts were coded for the presence of conventional forms (e.g., vocalization) and potentially communicative forms (e.g., body movement). Multilevel binomial regressions, fit with Bayesian inference, were conducted to predict classification of maternal endorsements of child communication based on the presence of conventional and potentially communicative forms as either an aligned act (i.e., act endorsed by mother and clinical researcher as communicative) or a unique maternal endorsement (i.e., act endorsed by mother but not clinical researcher).

Results:
The presence of vocalization, verbalization, and gesture each significantly predicted increased likelihood of alignment; the presence of eye contact did not. Although repetitive and sensory behaviors significantly increased the likelihood of unique maternal endorsement, affect shifts and body movements each significantly reduced the likelihood of unique maternal endorsement, and hand activity was not significantly predictive of unique maternal endorsement.

Conclusions:
Misalignment in mothers' and clinical researchers' identification of communication may be in part due to mothers' endorsement of behavioral forms that are not traditionally classified as part of a child's communication repertoire. Findings emphasize the need to work toward designing communication interventions that consider the ways in which clinicians and parents of autistic children each bring their own interpretive frameworks to the early intervention experience.
Tongue Shape Complexity in Children With and Without Speech Sound Disorders
Authors: Dokovova Marie , Sugden Ellie , Cartney Gemma , Schaeffler Sonja , Cleland Joanne 
Published: June 2023

Purpose:
This study investigates the hypothesis that younger speakers and speakers with more severe speech sound disorders are more likely to use simpler (undifferentiated) tongue gestures due to difficulties with, or immaturity of, lingual motor control.

Method:

The hypothesis is tested using cross-sectional secondary data analysis of synchronous audio and high-speed ultrasound recordings from children with idiopathic speech sound disorders (
n
= 30, aged 5;0–12;11 [years;months]) and typically developing children (
n
= 29, aged 5;8–12;10), producing /a/, /t/, /ɹ/, /l/, /s/, and /ʃ/ in an intervocalic /aCa/ environment. Tongue shape complexity is measured using NINFL (Number of INFLections) and modified curvature index (MCI) from splines fitted to ultrasound images at the point of maximal lingual gesture. Age, perceived accuracy, and consonant are used as predictors.

Results:
The results suggest that as age increases, children with speech sound disorders have lower MCI compared to typically developing children. Increase in age also led to decrease of MCI for the typically developing group. In the group of children with speech sound disorders, perceptually incorrect /ɹ/ productions have lower MCI than correct productions, relative to /a/.

Conclusions:
There is some evidence of systematic tongue shape complexity differences between typically developing children and children with speech sound disorders when accounting for increase in age. Among children with speech sound disorders, increase in age and perceptually incorrect consonant realizations are associated with decreasing tongue shape complexity.
Examining Inclusion in Speech-Language Pathology Graduate Programs Through Minoritized Students' Advice to a Peer
Authors: Roberts Teresa M. 
Published: June 2023

Purpose:
Speech-language pathology graduate programs exist within societal structures with uneven distribution of social goods (i.e., tangible and intangible concepts of value). As programs strive to increase inclusion of minoritized students, minoritized students' advice to a peer provides insight into their access to social goods and their use of agency to meet their goals. This study examined minoritized students' peer advice to inform graduate programs.

Method:
Peer advice about inclusion was solicited from 104 minoritized students in speech-language pathology graduate programs across 28 states as part of a larger survey. One open-ended question specifically asked participants to offer advice to another minoritized student about inclusion in their speech-language pathology graduate program. Qualitative analysis of themes used manual in vivo coding with regular audit memos. Focused analysis on verbs within discourse was also used to determine how the themes related to social goods and student agency.

Results:
Analysis of themes revealed a graduate school environment where minoritized students could anticipate the loss of social goods (e.g., lack of information, devaluing of identities, and limited relationships). Students used both personal agency to mitigate these losses and collective agency to frame diversity as an asset for clinical practice while supporting each other through a shared understanding of lived experiences.

Conclusions:
Strategies that may help increase inclusion for minoritized students in speech-language pathology graduate programs are offered. Strategies address students' emotional well-being, education in the service of communities, peer relationships, and valuing diversity.
Considering spatiotemporal evolutionary information in dynamic multi‐objective optimisation
Authors: Fan Qinqin , Jiang Min , Huang Wentao , Jiang Qingchao 
Published: June 2023

AbstractPreserving population diversity and providing knowledge, which are two core tasks in the dynamic multi‐objective optimisation (DMO), are challenging since the sampling space is time‐ and space‐varying. Therefore, the spatiotemporal property of evolutionary information needs to be considered in the DMO. In the present study, a sliding‐time‐window‐based population clustering method (SPC) is proposed to effectively solve dynamic multi‐objective optimisation problems (DMOPs). In the SPC, the knowledge is provided by saving historical data in the temporal dimension, and a spectral clustering method is used to divide the saved data into multiple neighbourhood subspaces for preserving population diversity in the spatial dimension. The SPC is incorporated into the RM‐MEDA and is compared with other recently proposed state‐of‐the‐art dynamic multi‐objective evolutionary algorithms (DMOEAs) on 14 DMOPs introduced in IEEE CEC2018. Simulation results demonstrate that the proposed method is capable of enhancing the tracking performance of the RM‐MEDA in the dynamically changing environments. Additionally, the SPC is utilised to solve an actual dynamic multi‐objective translation control problem of an immersed tunnel element. Results show that the proposed SPC outperforms the knee point‐based transfer learning method in terms of both computational cost and tracking performance.
Power user portrait model based on random forest
Authors: Yang Di , Ji Ming , Lv Yuntong , Li Mengyu , Gao Xuezhe 
Published: June 2023

AbstractWith the vigorous development of the energy Internet, all kinds of user information data are increasing day by day. How to comprehensively and deeply mine the effective information of users, develop a model to predict the behaviour characteristics of big data users, distinguish customer relationships, and provide an accurate basis for the next behaviour of users for various platforms have become one of the research hotspots of big data analysis of user behaviour. The data is sampled according to the feature vector of power user. The portrait mining of power user is conducted, and the user screening and analysis are conducted by using the measure of decision tree node purity in the model. The decision tree variable of the up–down stopping rule is generated. Then the results of the model and the Logistics model are tested and analysed, which can effectively predict the behaviour of power user. The proposed user strategy based on the characteristics of power consumption behaviour is analysed to verify the effectiveness of the scheme. The example shows that the model has a strong ability to distinguish and good stability than the traditional Logistics model, which can effectively predict the user's behaviour in advance, reduce user complaints, and help enterprises and users to form a long‐term mechanism of mutual benefit and reciprocity, which has a strong practical significance. This paper analyses the panorama of users through power big data technology and proposes a maturity model to evaluate the priority of users' electricity consumption. It emphasises the use of resources and methods provided in the power big data technology package to solve the practical problems of users' electricity consumption, and helps power companies to avoid market risks and improve service levels, which has strong practical significance.
A survey of conductive and radiated EMI reduction techniques in power electronics converters across wide‐bandgap devices
Authors: Li Chentao , Ma Qishuang , Tong Yajing , Wang Jinsong , Xu Ping 
Published: June 2023

AbstractNowadays, wide‐bandgap (WBG) devices, primarily made from silicon carbide (SiC) and gallium nitride (GaN), are widely applied in power generation, transmission, and conversion. Moreover, the application of WBG devices has had a transformative impact in the field of energy conversion. Compared with Si counterparts, SiC and GaN can remarkably improve the power conversion system efficiency and power density while generating higher electromagnetic interference (EMI) emissions. There are many studies on WBG devices and their behaviour in power systems. However, methods of mitigating EMI/electromagnetic compatibility (EMC) still lack scientific guidance. This article reviews the characteristics of WBG devices, and the significant EMI problems are discussed. Then, the EMI types, EMI causes, and methods of EMI reduction are summarized, and the advantages and disadvantages of these methods are presented as well. Based on the reviewed studies, future research, and the conclusions of this article on EMI/EMC are discussed to help relevant researchers deepen their understanding of the new challenges of EMI brought by the applications of WBG devices, which are useful in engineering.
Spectral analogues of Barbarian asteroids among CO and CV chondrites
Authors: Mahlke M. , Eschrig J. , Carry B. , Bonal L. , Beck P. 
Published: June 2023

Context. K- and L-type asteroids are considered to be the parent bodies of CV and CO chondrites. Spectral models of L-types invoke an enrichment in calcium-aluminium-rich inclusions (CAIs) with respect to the chondrites in the meteorite collection. Barbarian asteroids are associated to L-type asteroids yet the relationship between these populations is still not clear.
Aims. We aim to investigate the link between the K- and L-type and Barbarian asteroids and the CV and CO chondrites by means of spectral matching of a large number of reflectance spectra of objects from either population. We seek to identify matches based on observed rather than modelled spectral features.
Methods. We employ a matching criterion that accounts for the residuals and the correlation of the spectral features. The only free parameter in the comparison is the degree of alteration of the asteroids with respect to the meteorites expressed via an exponential model. We derive an absolute scale of similarity between the spectra using laboratory data from irradiation experiments.
Results. CVOxA chondrites are the best match to the asteroids, in particular to K-type (7 out of 11 asteroids matched) and Barbarians (11 out of 16). CO chondrites provide convincing matches for K-types (5 out of 11) and Barbarians (7 out of 16) as well. A single non-Barbarian L-type is matched to a meteorite. Only a few asteroids are matched to CVOxB and CVRed chondrites.
Conclusions. Barbarian asteroids are represented among CO and CVOxA chondrites without requiring an enrichment of CAIs in the asteroids. Four candidate Barbarian asteroids are identified, three of which are classified as K-types. These asteroids are favourable targets for polarimetric observations. The discrepancy between L-type asteroids and CV and CO chondrites is likely related to the ambiguity of the asteroid class itself. An extension of the taxonomy to include polarimetric properties is required.
Editorial
Authors: Forsting Michael 
Published: June 2023

Liebe Leserinnen und Leser,die Pandemie ist jetzt offiziell für beendet erklärt worden und ich
hoffe, dass die Normalität so langsam wieder in das Leben aller
zurückkehrt. Es war schon eine fast surreale Zeit für das
Privatleben, aber natürlich auch für unseren beruflichen Alltag.Die neue Ausgabe von Radiopraxis hat wieder 3 Schwerpunktthemen:
Therapie der kryptograndulären Analfisteln: aktuelle Goldstandards und Alternativen
Authors: Fritz Stefan , Reissfelder Christoph , Bussen Dieter 
Published: June 2023

ZusammenfassungKryptoglanduläre Analfisteln stellen eines der häufigsten kolorektalen Krankheitsbilder dar und treten mit einer Inzidenz von etwa 20/100000 Personen auf. Analfisteln sind definiert als
eine entzündliche Verbindung zwischen dem Analkanal und der perianalen Haut und können sich aus einem Abszess oder einem chronischen Infekt des Anorektums entwickeln. Die chirurgische
Behandlung der Erkrankung stellt das Mittel der Wahl dar. Bereits bei der Behandlung eines akuten Abszesses sollte gleichzeitig nach dessen Ursache gesucht werden. Findet sich eine
Verbindung zum Analkanal, ohne dass relevante Anteile der Sphinktermuskulatur betroffen sind, so sollte eine primäre Fistelspaltung durchgeführt werden. Werden größere Anteile des
Schließmuskels umfasst, so ist meist die Einlage einer Fadendrainage sinnvoll. Zur elektiven Behandlung von krytoglandulären Analfisteln gelten grundsätzlich zwei Empfehlungen. Distal
gelegene Fisteln sollten offengelegt werden unter der Maßgabe, möglichst wenig Sphinktermuskulatur zu opfern. Bei hoch proximalen und komplexen Fisteln sollten dagegen sphinkterschonende
Operationstechniken zum Einsatz kommen. Als Mittel der Wahl gilt hier der Mukosa- oder Advancement-Flap. Alternativ werden in der Literatur u. a. Clips, Fibrininjektionen, Fistel-Plugs,
Fistelligaturen oder auch laserbasierte Verfahren beschrieben. Bei intermediären Fisteln kann eine Fistulektomie mit primärer Sphinkterrekonstruktion sinnvoll sein. Jede Operation erfolgt
im Spannungsfeld zwischen definitiver Fistelheilung und potenzieller Gefährdung der Kontinenz des Patienten. Es ist häufig schwierig, eine verlässliche Prognose über die postoperativ zu
erwartende Kontinenzfunktion abzugeben. Neben der Fistelmorphologie ist insbesondere zu beachten, ob bereits proktologische Voroperationen vorliegen, welches Geschlecht der Patient hat und
ob Schließmuskelfunktionsstörungen vorbestehen. Da für den Erfolg der Behandlung auch die Expertise des Operateurs eine entscheidende Rolle spielt, sollte der Eingriff, insbesondere bei
komplexen Fisteln oder bei Z. n. Voroperationen, in einem proktologischen Schwerpunktzentrum durchgeführt werden. Die nachfolgende Arbeit beleuchtet neben den klassischen Verfahren wie der
Fistulektomie oder dem plastischen Fistelverschluss alternative Methoden und deren Einsatzbereiche.
Stammzelltherapie bei komplexen perianalen Fisteln bei Morbus Crohn: Aktuelle Evidenz und Ausblick
Authors: Schwandner Oliver 
Published: June 2023

ZusammenfassungTrotz Weiterentwicklungen in interdisziplinärer Diagnostik und Therapie stellen komplexe Analfisteln bei Morbus Crohn weiterhin eine Herausforderung für medikamentöse und chirurgische
Therapiekonzepte dar. Konventionelle chirurgische Techniken (u. a. Flap, LIFT) sind mit relativ hohen Persistenz- und Rezidivraten vergesellschaftet. Vor diesem Hintergrund zeigen
Ergebnisse der Stammzelltherapie eine vielversprechende, sphinkterschonende Therapieoption. Insbesondere die allogene mesenchymale Stammzelltherapie (Darvadstrocel) konnte im Rahmen der
randomisierten ADMIRE-CD-Studie eine hohe Wirksamkeit bei komplexen Crohn-Fisteln zeigen, die auch in limitierten „Real-World“-Daten reproduziert werden konnte. Die aktuelle Evidenz der
allogenen mesenchymalen Stammzellen hat hierbei auch Einzug in internationale Leitlinien erhalten. Inwieweit die allogene mesenchymale Stammzelltherapie in Zukunft eine effektive
Therapieoption im interdisziplinären Management der komplexen perianalen Fistel bei Morbus Crohn darstellt, kann derzeit noch nicht definitiv bewertet werden.