bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-aided Diagnosis and Analysis of Skin Cancer from Dermoscopic
Images in India
Authors: Brar Khushmeen Kaur , Shiney O. Jeba 
Published: April 2023

Background:
Researchers have made several advancements in this field, including automatic segmentation techniques, computer-aided diagnosis, mobile-based
technology, deep learning methods, hybrid methods etc. All these techniques are beneficial in diagnosing melanoma or segregating skin lesions
into different categories.

Aim:
This paper aims to define different types of skin cancers, diagnosis procedures and statistics. This paper presents skin cancer statistics over a period
of time in India. The increment in the number of skin carcinoma and melanoma cases from 1990 to 2020 as well as the mortality rates, has been
presented in this paper. Also, this paper provides a review of different technologies used by researchers in detecting melanoma.

Conclusion:
The rise in the number of cases by 2040 and mortality rates are compared. The statistics that are used in this paper are as per hospital-based cancer
registries (HBCR) 2021 prepared by the Indian Council of Medical Research - National Centre for Disease Informatics and Research, Bengaluru
(ICMR-NCDIR) and from World Health Organization (WHO).
Survey on Multi-omics, and Multi-omics Data Analysis, Integration and
Application
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: April 2023

Abstract:
Multi-omics approaches have developed as a profitable technique for plant systems, a
popular method in medical and biological sciences underlining the necessity to outline new integrative
technology and functions to facilitate the multi-scale depiction of biological systems. Understanding
a biological system through various omics layers reveals supplementary sources of
variability and probably inferring the sequence of cases leading to a definitive process. Manuscripts
and reviews were searched on PubMed with the keywords of multi-omics, data analysis,
omics, data analysis, data integration, deep learning multi-omics, and multi-omics integration. Articles
that were published after 2010 were prioritized. The authors focused mainly on popular
publications developing new approaches. Omics reveal interesting tools to produce behavioral
and interactions data in microbial communities, and integrating omics details into microbial risk
assessment will have an impact on food safety, and also on relevant spoilage control procedures.
Omics datasets, comprehensively characterizing biological cases at a molecular level, are continually
increasing in both dimensionality and complexity. Multi-omics data analysis is appropriate
for treatment optimization, molecular testing and disease prognosis, and to achieve mechanistic
understandings of diseases. New effective solutions for multi-omics data analysis together with
well-designed components are recommended for many trials. The goal of this mini-review article
is to introduce multi-omics technologies considering different multi-omics analyses.
Hybrid Organic Polymer/Inorganic Nano-materials for Biomedical Applications: Where we are and Where to go?
Authors: Massironi Alessio 
Published: April 2023

Abstract:
Hybrid functional materials, composed of inorganic and organic components, are considered
versatile platforms whose applications in electronics, optics, mechanics, energy storage, informatics,
catalysis, sensors, and medicine field have represented a breakthrough for human well-being.
Among hybrid materials, micro/nanostructured hybrid colloidal systems have been widely investigated
due to the dramatic enhancement of activity provided by the large surface area exposed at the
interfaces with respect to the bulk counterpart. Recently, a growing interest has been in the exploration
of novel environmental-friendly and versatile procedures that allow the formulation of hybrid
nanostructures through safety procedures and mild experimental conditions. This review aims to
provide an introduction to hybrid organic-inorganic materials for biomedical applications in particular
nanostructured ones, describing the commonly exploited materials for their fabrication and techniques,
advantages, and drawbacks.
Effect of Apigenin on Neurodegenerative Diseases
Authors: Gaur Kajal , Siddique Yasir Hasan 
Published: April 2023

Abstract:
Neurodegenerative diseases (NDDs), such as Alzheimer's and Parkinson's, are the most frequent
age-related illnesses affecting millions worldwide. No effective medication for NDDs is known
to date and current disease management approaches include neuroprotection strategies with the hope
of maintaining and improving the function of neurons. Such strategies will not provide a cure on their
own but are likely to delay disease progression by reducing the production of neurotoxic chemicals
such as reactive oxygen species (ROS) and related inflammatory chemicals. Natural compounds such
as flavonoids that provide neuroprotection via numerous mechanisms have attracted much attention in
recent years. This review discusses evidence from different research models and clinical trials on the
therapeutic potential of one promising flavonoid, apigenin, and how it can be helpful for NDDs in the
future prospects. We have also discussed its chemistry, mechanism of action, and possible benefits in
various examples of NDDs.
A Review of the Research on Electro-hydraulic Load Simulator and
Characteristics with Improvement Methods
Authors: LI Jianying , Li Weidong , Liang Heng , Kong Lingbing 
Published: April 2023

Abstract:
The electro-hydraulic load simulator is a semi-physical simulation system. It is used to
simulate different loads on the bearing capacity object (steering gear system) under working conditions
and further test the dynamic and static characteristics of the bearing capacity object. Therefore,
it is widely used in important applications such as the simulation of various loads and the development
of high-performance steering gear systems. By analyzing and discussing the electro-hydraulic
load simulator equipment and its improvement methods, some useful conclusions have been drawn
to predict the development of the electro-hydraulic load simulator and its key technologies. The
current status of research on electro-hydraulic load simulator prototypes is discussed in depth.
The electro-hydraulic load simulators are classified according to the loading system applying
force (torque). The improvement methods of the electro-hydraulic load simulator, including the
method of suppressing the extraneous force, the compensation method of nonlinear factors, and
the method of establishing the mathematical model, are analyzed and summarized. By summarizing
the literature and patents on electro-hydraulic load simulation technology, the principle, and
characteristics of different equipment and improvement methods are analyzed and compared, and
future development of electro-hydraulic load simulation equipment and technology is discussed.
The research on the characteristics of the prototype, the hardware means and control strategy to
suppress the extraneous force, the compensation of nonlinear factors, and the methods of establishing
the mathematical model are beneficial to improve the loading accuracy of the electro-hydraulic
load simulator.
Treating Sensorineural Hearing Loss: Recent Advances in Inner Ear Drug
Delivery
Authors: Vachheta Dolly N. , Shah Yamini Dushyant , Athalye Mansi Ninaad , Kakkad Drashty Kumarbhai , Darji Mansi Jitenderabhai 
Published: April 2023

Abstract:
This review aims to provide historical, present, and future drug deliveries for treating in-ner ear disorders. Systemic delivery, such as antibiotics and steroids for the inner ear, was the basis on which current drug delivery systems and devices have been researched and developed. Re-searchers and clinicians had to develop and deliver drugs locally due to adverse effects caused by drugs systemically. Intratympanic method of antibiotics and steroid delivery has been common; however, newer techniques such as microcatheter implantation, hydrogels, nanoparticles, and intra-cochlear implants are being investigated successfully. Recently advances in microfluidic and mi-crosystems technology have applied medications directly into the inner ear. This technology will also be adopted to deliver gene therapy, RNA interference technology, and stem cell therapy by cli-nicians in the future.
Current Prospects in Rheumatoid Arthritis: Pathophysiology,
Genetics, and Treatments
Authors: Khan Shoaib , Mohan Krishna , Muzammil Sazina , Alam Md. Aftab , Khayyam Khalid Umer 
Published: April 2023

Abstract:
An autoimmune inflammatory disease, rheumatoid arthritis (RA), predominantly
affects the synovium joint lining, augmenting disability, early mortality, and socioeconomic
difficulty. Therefore, current updates on pharmacological therapies are crucial for
developing drugs to treat the disease at each stage. This review attempts to compile a thorough
analysis of current developments in our knowledge of RA pathogenesis and diseasemodifying
drugs, with the aim of providing insights for next-generation RA therapeutics.
According to the literature, the most successful drugs for treatment techniques described so
far in this area include (cs) DMARDs (sub-class of disease modifying anti-rheumatic
drugs DMARDs), tsDMARDS (targeted synthetic DMARDS), and bDMARDs (biological
DMARDs). However, current pharmacologic therapy consisting of biological, conventional,
and potentially viable small molecule DMARDs remains the cornerstone of
rheumatoid arthritis treatment with which significant progress toward disease remission
has been accomplished. The pathobiology of RA involves cytokine messengers such as B
and T-cells, and an intricate interplay of pro-inflammatory cytokines responsible for activating
and developing effector cells, in turn, accountable for local disease and systemic
symptoms. Despite the fact that the cause of rheumatoid arthritis is not known, new treatments
have been created as a result of better approaches towards the biology of the disease. As they
target molecules directly implicated in the genesis of rheumatoid arthritis, these drugs may be
more effective, targeted, and less harmful in the short and long term than standard therapies.
The Spatiotemporal Pattern and Its Determinants of Hemorrhagic Fever With Renal Syndrome in Northeastern China: Spatiotemporal Analysis
Authors: Wang Yanding , Wei Xianyu , Jia Ruizhong , Peng XingYu , Zhang Xiushan , Yang Meitao , Li Zhiqiang , Guo Jinpeng , Chen Yong , Yin Wenwu , Zhang Wenyi , Wang Yong 
Published: April 2023

Background
Hemorrhagic fever with renal syndrome (HFRS) is a significant zoonotic disease mainly transmitted by rodents. However, the determinants of its spatiotemporal patterns in Northeast China remain unclear.

Objective
This study aimed to investigate the spatiotemporal dynamics and epidemiological characteristics of HFRS and detect the meteorological effect of the HFRS epidemic in Northeastern China.

Methods
The HFRS cases of Northeastern China were collected from the Chinese Center for Disease Control and Prevention, and meteorological data were collected from the National Basic Geographic Information Center. Times series analyses, wavelet analysis, Geodetector model, and SARIMA model were performed to identify the epidemiological characteristics, periodical fluctuation, and meteorological effect of HFRS in Northeastern China.

Results
A total of 52,655 HFRS cases were reported in Northeastern China from 2006 to 2020, and most patients with HFRS (n=36,558, 69.43%) were aged between 30-59 years. HFRS occurred most frequently in June and November and had a significant 4- to 6-month periodicity. The explanatory power of the meteorological factors to HFRS varies from 0.15 ≤ q ≤ 0.01. In Heilongjiang province, mean temperature with a 4-month lag, mean ground temperature with a 4-month lag, and mean pressure with a 5-month lag had the most explanatory power on HFRS. In Liaoning province, mean temperature with a 1-month lag, mean ground temperature with a 1-month lag, and mean wind speed with a 4-month lag were found to have an effect on HFRS, but in Jilin province, the most important meteorological factors for HFRS were precipitation with a 6-month lag and maximum evaporation with a 5-month lag. The interaction analysis of meteorological factors mostly showed nonlinear enhancement. The SARIMA model predicted that 8,343 cases of HFRS are expected to occur in Northeastern China.

Conclusions
HFRS showed significant inequality in epidemic and meteorological effects in Northeastern China, and eastern prefecture-level cities presented a high risk of epidemic. This study quantifies the hysteresis effects of different meteorological factors and prompts us to focus on the influence of ground temperature and precipitation on HFRS transmission in future studies, which could assist local health authorities in developing HFRS-climate surveillance, prevention, and control strategies targeting high-risk populations in China.
A Web-Based Sexual Violence, Alcohol Misuse, and Bystander Intervention Program for College Women (RealConsent): Randomized Controlled Trial
Authors: Salazar Laura Francisca , Schipani-McLaughlin Anne Marie , Sebeh Yesser , Nizam Zainab , Hayat Matt 
Published: April 2023

Background
Sexual violence (SV) incidence among college women has been invariant for the past 20 years. Innovative prevention strategies that are low resource and technology driven but demonstrate efficacy are greatly needed.

Objective
The aim of this study was to determine the efficacy of a novel theoretically driven internet-based intervention for first-year college students who identify as women (RealConsent) in reducing their risk of exposure to SV and alcohol misuse as well as increasing alcohol protective and bystander behaviors.

Methods
This randomized controlled trial involved first-year college students who identified as women (n=881) attending 1 of 3 universities in the southeastern United States. Participants aged 18 to 20 years were randomized to RealConsent (444/881, 50.4%) or to an attention-matched placebo control (437/881, 49.6%). RealConsent is fully automated and consists of four 45-minute modules that incorporate entertainment-education media and proven behavior change techniques. The primary outcome was exposure to SV; the secondary outcomes were alcohol protective behaviors, dating risk behaviors, alcohol misuse, and bystander behavior. Study outcomes were assessed at baseline and 6-month follow-up.

Results
Among participants with some exposure to SV, those in the RealConsent group experienced less exposure to SV than the placebo group (adjusted incidence rate ratio 0.48, 95% CI 0.33-0.69; P=.002). Furthermore, participants in the RealConsent group engaged in more alcohol protective behaviors (adjusted odds ratio 1.17, 95% CI 0.12-2.22; P=.03) and were less likely to binge drink (adjusted incidence rate ratio 0.81, 95% CI 0.67-0.97; P=.003). Finally, participants in the RealConsent group who had 100% dosage were more likely to engage in bystander behavior than those with <100% dosage plus placebo group (adjusted odds ratio 1.72, 95% CI 1.17-2.55; P=.006).

Conclusions
A comprehensive exposure to SV, alcohol use, and bystander educational program was successful in decreasing the occurrence of exposure to SV among those most at risk and in increasing alcohol protective behaviors. Because of its web-based and mobile technologies, RealConsent can be easily disseminated and holds potential for reducing campus SV.

Trial Registration
ClinicalTrials.gov NCT03726437; https://clinicaltrials.gov/ct2/show/NCT03726437
Impact of Social Isolation, Physician-Patient Communication, and Self-perception on the Mental Health of Patients With Cancer and Cancer Survivors: National Survey Analysis
Authors: Choudhury Avishek 
Published: April 2023

Background
Cancer is perceived as a life-threatening, fear-inducing, and stigmatized disease. Most patients with cancer and cancer survivors commonly experience social isolation, negative self-perception, and psychological distress. The heavy toll that cancer takes on patients continues even after treatment. It is common for many patients with cancer to feel uncertain about their future. Some undergo anxiety, loneliness, and fear of getting cancer again.

Objective
This study examined the impact of social isolation, self-perception, and physician-patient communication on the mental health of patients with cancer and cancer survivors. The study also explored the impact of social isolation and physician-patient communication on self-perception.

Methods
This retrospective study used restricted data from the 2021 Health Information National Trends Survey (HINTS), which collected data from January 11, 2021, to August 20, 2021. We used the partial least squares structural equation modeling (PLS-SEM) method for data analysis. We checked for quadratic effects among all the paths connecting social isolation, poor physician-patient communication, mental health (measured using the 4-item Patient Health Questionnaire [PHQ-4]), and negative self-perception. The model was controlled for confounding factors such as respondents’ annual income, education level, and age. Bias-corrected and accelerated (BCA) bootstrap methods were used to estimate nonparametric CIs. Statistical significance was tested at 95% CI (2-tailed). We also conducted a multigroup analysis in which we created 2 groups. Group A consisted of newly diagnosed patients with cancer who were undergoing cancer treatment during the survey or had received cancer treatment within the last 12 months (receipt of cancer treatment during the COVID-19 pandemic). Group B consisted of respondents who had received cancer treatment between 5 and 10 years previously (receipt of cancer treatment before the COVID-19 pandemic).

Results
The analysis indicated that social isolation had a quadratic effect on mental health, with higher levels of social isolation associated with worse mental health outcomes up to a certain point. Self-perception positively affected mental health, with higher self-perception associated with better mental health outcomes. In addition, physician-patient communication significantly indirectly affected mental health via self-perception.

Conclusions
The findings of this study provide important insights into the factors that affect the mental health of patients with cancer. Our results suggest that social isolation, negative self-perception, and communication with care providers are significantly related to mental health in patients with cancer.
Documentos sobre Málaga y el tráfico con las Indias
Authors: López Beltrán María Teresa 
Published: April 2023

La finalidad de este artículo es, no sólo dar a conocer un documento conservado en el Archivo Histórico Provincial de Málaga referido a la armada de Fernando de Magallanes poco antes de partir hacia las Molucas, sino, sobre todo, hacer hincapié en el hecho de que, pese a no constatarse documentalmente la existencia de un tráfico directo de Málaga con Indias desde la promulgación de la cédula de Carlos I en 1529 autorizando a diversos puertos españoles a comerciar directamente con aquéllas, Málaga participa activamente en el comercio americano, abasteciendo de productos típicos de su tierra a las armadas que partían para Indias y a sus colonias, si bien lo hace teniendo como intermediarios a los puertos de la Baja Andalucía. Sirva como ejemplo el documento segundo del apéndice de este artículo.
Notas sobre el yacimiento arqueológico de la Loma de Benagalbón
Authors: Serrano Ramos Encarnación 
Published: April 2023

Al Este de Málaga (Rincón de la Victoria), hace cuatro años, llevamos a cabo una excavación de urgencia en una villa romana cuyos resultados queremos relatar en estas páginas. La novedad más importante fue el descubrimiento de unas termas. Aunque el lugar estuvo habitado desde el siglo VII antes de C. al V después de C.,han sido las construcciones romanas los descubrimientos más sobresalientes.
La mentalidad rigorista en Málaga barroca
Authors: Gil Sanjuán Joaquín 
Published: April 2023

El rigorismo teórico fue una de las características más acusadas del jansenismo, movimiento religioso que desató en Francia una tormentosa y larga controversia, cuyas repercusiones las podemos ver en la Málaga de la segunda mitad del XVII en torno a la figura de fray Alonso de Santo Tomás por su intransigencia en cuestiones morales. Las constituciones del Sínodo celebrado en 1671, bajo la influencia y supervisión de este prelado, son una muestra evidente de rigorismo práctico que trató de imponerse en la sociedad malagueña durante las últimas décadas del siglo XVII.
Evolución del sistema de asentamientos de la provincia de Málaga (1900-1991)
Authors: Natera Rivas Juan José 
Published: April 2023

Se trata de aplicar diferentes medidas estadísticas para calibrar los cambios que el sistema de asentamientos malagueño ha sufrido a lo largo del siglo, interpretándolos en relación con los cambios que en su explotación económica se han producido.
Un recuerdo para la reina Mariana de Austria en el III Centenario de su muerte: Exequias por la Reina en Málaga (16 de mayo de 1696)
Authors: Reder Gadow Marion 
Published: April 2023

En el mes de mayo de este año de 1996 se conmemora el III Centenario de la muerte de la reina Mariana de Austria. El presente estudio pretende recordar esta efemérides analizando el eco que tuvo en Málaga la noticia del fallecimiento de la reina Madre que durante una década había gobernado la Monarquía Hispánica durante la minoría de su hijo Carlos.
Distribución social de la crisis económica en América Latina y nuevas tendencias tras la recuperación
Authors: Natera Rivas Juan José 
Published: April 2023

La crisis de la deuda externa trajo consigo el agravamiento de la situación social en los países latinoamericanos, en parte como consecuencia de las políticas de ajuste que debieron ser implementadas. No obstante, la actual recuperación económica no ha supuesto la recuperación de los indicadores sociales; antes al contrario, éstos muestran unos niveles peores incluso a los que se registraban a principios de los ochenta. En los párrafos que siguen pasamos revista a alguno de los factores que están en la base de esta situación.
Historia y didáctica en la universidad: algunas notas
Authors: Wulff Alonso Fernando 
Published: April 2023

El autor plantea la necesidad de una reflexión sobre la enseñanza de la historia en la universidad desde el punto de vista de la didáctica. Los cambios en las ideas sobre este campo en la enseñanza secundaria hacen más fácil un debate que deberá partir en buena parte de este ámbito. Plantea también tres puntos de partida: el valor cognitivo de la historia, la problemática de los usos múltiples de! pasado en nuestra cultura y la necesidad de definir un canon cultural como un núcleo esencial de cualquier proyecto de enseñanza.
Elaboración de tipos fisonómicos de relieve a partir de morfometría de laderas y de datos procedentes de cartografía automática y SIG
Authors: Perles Roselló Mª Jesús , Vías Martínez Jesús Mª 
Published: April 2023

El presente articulo ofrece los pasos de elaboración y resultados de la aplicación de una clasificación del relieve basada en distintos estimadores de morfometría de laderas.Se persigue poner a prueba la metodología de clasificación, así como la determinación de tipos y cartografía de unidades de características morfológicas similares. La aplicación se ha realizado en una zona de las cordilleras béticas en el sector oriental de la provincia de Málaga.