bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized study of the effects of Empagliflozin and Topiramate dual therapy on anthropometric and metabolic indices in non-diabetic individuals with overweight/obesity on a calorie-restricted diet
Authors: Abiri Behnaz , Ahmadi Amirhossein Ramezani , Hosseinpanah Farhad , Zarghi Afshin , Valizadeh Majid 
Published: August 2023

Abstract
Objectives: The objective of this study was to evaluate the effectiveness of the combined use of empagliflozin (EMPA) and topiramate (TPM) versus a placebo in overweight/obese individuals without diabetes on a calorie-restricted diet.
Methods: In this study, 44 non-diabetic and overweight/obese subjects who were on a calorie restricted diet were randomly assigned into 2 groups: 1) Participants received a 10 mg EMPA tablet daily plus TPM tablet (at the first week 25 mg once a day and from the second week 25 mg twice a day); 2) Participants received an empagliflozin placebo (daily) plus a topiramate placebo (as mentioned for topiramate tablet in group 1), for 12 weeks. At baseline and weeks 4, 8, 12, weight, height, body mass index (BMI), waist circumference (WC), and body composition were evaluated. Before and after the intervention, blood pressure, C reactive protein, and glucose and lipid profile parameters were measured.
Results: The EMPA/TOP group, compared to placebo, had a greater percent change of weight at week 12 (-8.92 ± 1.80 vs. -4.93 ± 1.17). The intervention group had a greater percent change of fat mass and fat percent at week 12 (P<0.05). However, there was no difference in the percent of change in fat-free percent between the two groups at week 12 (P=0.577). Within-group analysis found a significant reduction in SBP, DBP, FBS, insulin, HOMA-IR, TC, LDL, HDL, TG, and CRP in both groups (P<0.05). The Time × Group effect was significant only for DBP (P=0.034). At week 12, no statistically significant difference was observed between the two groups in any of mentioned variables (P>0.05).
Conclusion: In non-diabetic overweight/obese individuals, the combination of EMPA/TPM and calorie restriction led to a notable decrease in body weight and was generally well-tolerated. Further research is required to evaluate the potential advantages of utilizing this combination for sustained weight management in the long run.

Name of the registry: Iranian Registry of Clinical
Trials
Trial registration number: IRCT20230114057122N1
Date of registration: 2/1/3/2023 'Retrospectively
registered'
URL of trial registry record:
https://www.irct.ir/trial/68026
Geographic origin and host’s phylogeny are predictors of the gut mucosal microbiota diversity and composition in Mediterranean scorpionfishes (Scorpaena sp.)
Authors: Lilli Ginevra , Sirot Charlotte , Campbell Hayley , Brophy Deirdre , Graham Conor , George Isabelle 
Published: August 2023

Abstract
Background
The gut microbiome holds an important role in the health and homeostasis of fishes. However, despite the large diversity and distribution of this vertebrate group, only the intestinal microbiome of a limited number of freshwater and marine fish species has been well characterized to date. Mediterranean scorpionfishes (Scorpaena sp) have a high commercial value in the Mediterranean Sea and Scorpaena scrofa is a candidate to become an aquaculture-reared species in a near future. However, this fish group is underrepresented in studies about fish gut microbiome.
Results
In this study, we characterized the gut mucosal microbial communities of three Scorpaena sp (n = 125) by using a comprehensive comparative dataset including 16S rRNA gene amplicon data from four different locations in the Mediterranean Sea. We report that in this fish group, geographical origin influences the diversity and the composition of the gut microbial communities more than host’s phylogenetic relatedness. Moreover, we observe a positive correlation between the composition of the gut microbiota and the phylogenetic distance between the hosts (i.e. phylosymbiosis). Finally, the core microbiota of each species was described both regionally and across the Mediterranean Sea. When investigated regionally, the core microbiota was characterized by bacterial genera holding important functions for the health and homeostasis of the host. By expanding the analysis to a broader geographical scale, a reduction in the size of the core microbiota of each species was observed and Clostridium senso stricto 1 appeared to be the only resident bacterial genus in the core gut microbiota of Scorpaena sp in the Mediterranean Sea.
Conclusion
This study reveals that the microbiota associated with the gut mucosa of scorpionfishes is not stable across the Mediterranean Sea and its composition depends on the fish population analyzed. Therefore, it highlights the importance of investigating the gut microbiome through the geographical range of a species and it suggests this as a general procedure to better characterize the gut microbial ecology of each fish species
Increased rates of invasive bacterial disease in late 2022
Authors: Kyne Sarah , Shiochain Doireann Ni , McDonnell Caoimhe , Byrne Aisling , Sutton-Fitzpatrick Una , Crowley Niamh , Nertney Leona , Myers Conor , Waldron John , Ahmed Aneeq , Wrynne Caragh , Fennell Jerome , Fitzpatrick Patrick , Fitzsimons John J , Scanlan Barry , Vaughan David , Gorman Kathleen M , Cunney Robert , Smyth Anna E. , Hourihane Jonathan O’B 
Published: August 2023

Abstract
Purpose:
Invasive bacterial disease is associated with significant morbidity and mortality. In winter 2022, there was an apparent increased rate of invasive bacterial disease compared to preceding years.
Methods:
Cross-site retrospective analysis of the three Children’s Health Ireland (CHI) hospitals looking at children admitted between 1st October 2022 – 31st December 2022 (Q4) with community-acquired invasive bacterial disease, defined as an abscess in a normally sterile site in the head, neck and chest or isolation or PCR detection of Streptococcus pneumoniae, Neisseria meningitidis, Streptococcus pyogenes (Group A streptococcus), or Haemophilus influenzae from a normally sterile site. Case numbers were compared to Q4 in each of 2018 – 2021.
Results:
82 children met the case definition in Q4 2022 vs 97 (Q4 2018 – 2021). In 2022, 42/82 (51%) were female, median age 3.75y (1.5-8.25y). Only 2 (2%) were immunosuppressed and 2 others (2%) had underlying neurodisabiltiy. Fifty (61%) were admitted on second or subsequent presentation to a healthcare setting. Fifty-six (68%) had an abscess in a sterile site. Bloodstream infection (positive blood culture or PCR: 24 (29%)) was the most common site of infection, followed by neck 22 (27%) and intracranial 12 (15%). Group A streptococcus (GAS) 27 (33%) was the most common organism isolated. Seven cases (9%) died in 2022 compared to 2 patients (2%) from 2018 – 2021 (p <0.05). More children had Paediatric Overall Performance Category (POPC) scores>1 in 2022 than 2018 – 2021 (p=0.003).
Conclusion:
Invasive bacterial diseases increased in Q4 2022 with higher morbidity and mortality than in the preceding 4 years. Group A streptococcal infection was the most significant organism in 2022.
Lymph node ratio has greater prognostic value than positive lymph node count in papillary renal cell carcinoma
Authors: Zhao Lun , Fu Yang , Hou Chao , Mao Fei , Ji Lu , Liu Xuzhong , Zhong Bing , Wang Gongcheng 
Published: August 2023

Abstract
Purpose
Approximately 10–15% of renal cell carcinoma (RCC) cases are papillary renal cell carcinoma (pRCC). pRCC is associated with a higher risk of lymph node metastases than clear cell RCC. The objective of this study was to compare the predictive significance of positive lymph node count (PLNC) versus lymph node ratio (LNR) in pRCC.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was searched, and a total of 372 patients with pRCC were selected. The optimum cut-off values for PLNC and LNR were determined. We performed χ2 or Fisher’s exact probability test to determine whether certain clinicopathological traits were associated with LNR or PLNC. Independent predictors of 5-year overall survival (OS) and 5-year cancer-specific survival (CSS) were determined using univariate and multivariate Cox proportional hazards regression analyses. The association between LNR and PLNC was determined using Spearman correlation analysis.
Results
Patients with high levels of LNR or PLNC were associated with advanced 6th/7th American Joint Committee on Cancer (AJCC) stage, T stage, N stage, M stage, and higher pathological grade. According to the univariate Cox proportional hazards regression analysis, the 6th/7th AJCC stage, T stage, N stage, M stage, tumor size, pathological grade, radiotherapy, chemotherapy, PLNC, and LNR were significantly linked to prognosis. Unlike PLNC, LNR was an independent predictive factor for OS and CSS based on the multivariate Cox proportional hazards regression analysis. A subgroup analysis of patients with positive nodes corroborated these findings.
Conclusion
LNR may have greater prognostic value than PLNC in pRCC.
Construction of a potato moisture diagnosis model based on hyperspectral characteristic parameters
Authors: Suyala Qiqige , Zhang Zhenxin , Jia Liguo , Fan Mingshou , Tian Yanhua , Kang Sarula 
Published: August 2023

Abstract
Proper water supply is crucial for high-yielding and high-quality potato tubers. Therefore, the accurate monitoring of potato water and precision irrigation based on water scarcity information has important practical significance for potato water-saving management. Hyperspectral remote sensing has unique advantages in diagnosing crop water stress. In this paper, we measured the canopy spectral reflectance and plant water content under five irrigation treatments. The characteristic spectral parameters that responded to plant water status were selected, and a hyperspectral moisture diagnosis model of the potato leaf water content (LWC) and aboveground water content (AGWC) was established. We found that both the potato LWC and AGWC significantly decreased with increasing water stress. The potato canopy hyperspectral reflectance peak appeared in the red edge region, and this area’s reflectance varied significantly under different water treatments and decreased with decreased irrigation. Six potato moisture monitoring models with the sensitive band, first derivative, and water spectral index were established. The R2 values of the partial least squares regression (PLSR), support vector machine (SVM), and BP neural network (BP) models between the LWC and hyperspectral data were 0.8418, 0.9020, and 0.8926, respectively. The R2 of the PLSR, SVM, and BP models between the AGWC and the hyperspectral data reached 0.8003, 0.8167, and 0.8671, respectively. All of the six models can realize the prediction of potato plant water content, but SVM was the best model for predicting the LWC of potato. These results will be highly significant in guiding the precision irrigation of different growth stages of potatoes.
Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response
Authors: Hu Zheng , Chen Shaoqing , Xie Duo , Wang Jiguang , Zhou Da 
Published: August 2023

Abstract
Cancer progression is an evolutionary process undergoing stringent immune selection. However, recent studies have revealed that certain tumors undergo neutral evolution following the malignant transformation. Here, we propose negative frequency-dependent selection (or NFDS), where the immune response against cancer cells depends on the clonality of neoantigens, can lead to an immunogenic landscape that is similar to neutral evolution. With a stochastic model of NFDS, we demonstrated that NFDSpromotes early immune evasion in hypermutable tumors, leading to neutral-like evolutionary dynamics with high antigenic heterogeneity and worse response to immune checkpoint blockade (ICB) therapy. Our model also revealed that NFDSis characterized by a negative association between average clonality and total burden of neoantigens. Indeed, NFDS was validated with whole-exome sequencing datasets (357 tumor samples from 275 patients) from four melanoma cohorts with ICB therapy. Altogether, our study provides the first quantitative evidence supporting the theory of NFDS in immune-driven cancer evolution. These findings highlight the critical role of NFDS theory in devising more efficient and predictive immunotherapies.
Giant adiabatic temperature change and its direct measurement of a barocaloric effect in a charge-transfer solid
Authors: Ohkoshi Shin-ichi , Nakagawa Kosuke , Yoshikiyo Marie , Namai Asuka , Imoto Kenta , Nagane Yugo , Jia Fangda , Stefańczyk Olaf , Tokoro Hiroko , Wang Junhao , Sugahara Takeshi , Chiba Kouji , Kazuhiko Motodohi , Isogai Kazuo , Nishioka Koki , Momiki Takashi , Hatano Ryu 
Published: August 2023

Abstract
Solid refrigerants exhibiting a caloric effect upon applying external stimuli may be an alternative to gaseous refrigerants. Herein, we report a new inorganic refrigerant, rubidium cyano-bridged manganese–iron–cobalt ternary metal assembly (cyano-RbMnFeCo). Cyano-RbMnFeCo shows a giant reversible barocaloric effect with extremely large reversible adiabatic temperature changes (|∆Tad,rev|) of 74 K (from 57 ℃ to −17 ℃) at 340 MPa, and 85 K (from 88 ℃ to 3 ℃) at 560 MPa. These are the largest |∆Tad,rev| values reported among all caloric effects. The reversible refrigerant capacity (RCrev) of 26000 J kg−1 and temperature window (Tspan,rev) of 142 K are also the largest values. Additionally, cyano-RbMnFeCo shows barocaloric effects even at low pressures, e.g., |∆Tad,rev| = 21 K at 90 MPa. Furthermore, direct measurement of the temperature change (∆Tobs) using a thermocouple shows ∆Tobs = +44 K by applying pressure, which is the largest practically measured temperature change among all caloric effect materials. The temperature increase and decrease upon pressure application and release is repeated over 100 cycles without any degradation of the ∆Tobs performance. This material series also possesses a high thermal conductivity value of 20.4 W m−1 K−1. The present barocaloric material may realize a high-efficiency solid refrigerant.
Fast aerodynamics prediction of wedge tail airfoils using multi-head perceptron network
Authors: Hasan Md. Moynul , Rahaman Md. Mashiur , Zakaria N. M. Golam 
Published: August 2023

Abstract
The study aimed to predict the flow fields and aerodynamic coefficients of wedge tail airfoils using a multi-head perceptron (MHP) network and classical machine learning (ML) algorithms, including k-nearest neighbors (KNN), decision tree (DT), and random forest (RF). These predictions were based on airfoil sections, x-y grid coordinates, Mach number, and angle of attack, eliminating the need to solve the Navier-Stokes (NS) equations. The database required for training the MHP network and the ML models were generated using the Ansys solver, which solved the NS equations. The results of the models were compared, and it was observed that the MHP network consistently outperformed the others in terms of prediction accuracy. The R2 score of these models on the test data was found to be close to 1. Additionally, the prediction process demonstrated a significant speed improvement of 125 times compared to conventional computational fluid dynamics (CFD) techniques. Once the training was completed, the flow fields and aerodynamic coefficients for a wedge tail airfoil could be obtained within seconds.
Investigating the PI3P binding pockets of Plasmodium falciparum HSP70 proteins
Authors: Upadhyay Vipul , Kaur Satinder , hora Rachna , Mishra Prakash Chandra 
Published: August 2023

Abstract
The 70 kDa Plasmodium falciparum (Pf) heat shock proteins (PfHSP70s) are an important class of molecules that are critically involved in parasite survival through periods of stress. Interaction between the cytosolic PfHSP70-1 and a crucial lipid modulator, phosphatidylinositol 3 phosphate (PI3P) stabilizes the parasite digestive vacuole (DV) to facilitate haemoglobin trafficking and breakdown in turn impacting parasite survival. The PI3P binding region on PfHSP70-1 is hosted by its C-terminal LID domain that controls substrate binding. Lipidic regulator ‘PI3P’ and PfHSP70 homologs are amply expressed together in various subcellular compartments of the parasite providing these with an opportunity to interact and affect biological processes. Here, we have identified and analysed the PI3P binding pockets of all four PfHSP70s by using structural bioinformatics tools in an attempt to understand their interaction with this lipid. Our results show that differently localized PfHSP70 homologs bind PI3P with variable affinity. Analysis of these results has also helped to pinpoint specific residues on PfHSP70s that may be engaged in these interactions. The present study may therefore form the basis for designing interventions that hinder PfHSP70-PI3P interaction and influence parasite survival.
Effect of Social Media Usage on Digital Carbon Footprint: Analyzing Awareness Level of Social Media Users of Punjab
Authors: Naeem Roha , Bajwa Amir Mehmood , Sattar Humayun , Naeem Bisma 
Published: August 2023

Abstract
The increasing use of social media platforms has raised concerns about its environmental impact in terms of digital carbon footprint. This research aims to analyze the awareness level of social media users in Punjab, Pakistan, regarding the concept of digital carbon footprint, and to identify the pro environmental behaviors that can encourage social media users to reduce their social media usage. Additionally, this research is considered to resolve the extent of coverage given to digital carbon footprint issue by English Dailies of Pakistan. Quantitative approach with two research designs i.e. survey and content analysis has been used to reach the desired objectives. The data of DAWN and Express Tribune is collected through content analysis within the selected time period (2020-2022). The major issues selected for the content analysis study are Carbon Emissions, Internet carbon emissions, Electronic Waste, Gaming carbon emission and social media carbon emission. The research was carried out under the umbrella of Agenda setting theory and Theory of planned behavior. For the survey design, a simple random sampling technique was employed to select sample (n=335) respondents between the ages of 18 and 26 from Lahore, Okara, Faisalabad, and Rawalpindi. The findings reveal a lack of awareness among social media users in Punjab regarding digital carbon footprint which is due to limited coverage provided by print media on this issue However, the results also highlights the potential of pro-environmental behavior as a means to reduce social media usage which indirectly decreases the digital carbon footprint., Ultimately, this research aims to foster a more environmentally conscious digital society by promoting responsible social media use and reducing the digital carbon footprint.
PENINGKATAN KREATIVITAS ANAK UMUR 7-8 TAHUN MELALUI PENDAMPINGAN SESI AKTIVITAS IBADAH ANAK DARING
Authors: Ratnasari Anisza 
Published: August 2023

Kondisi pandemi memaksa anak-anak untuk bermain, belajar dan beribadah di rumah. Ibadah anak daring harus memiliki esensi yang sama dengan ibadah onsite. Sesi pujian, cerita dan aktivitas disusun dengan mempertimbangkan kemampuan fisik, kognitif, motorik dan verbal anak. Kegiatan yang merupakan bagian dari komisi anak GKI GS ini dilakukan daring setiap Minggu pukul 10.30-11.45 WIB. Pelaksanaannya berfokus pada jenjang kelas tengah, yaitu anak usia 7-8 tahun (kelas 2) yang berjumlah 47 anak. Bentuk kegiatan pelayanan ini dilakukan melalui pendampingan sesi ibadah, mulai; salam pembuka, pujian, persembahan, cerita dan sesi aktivitas. Pengajar secara interaktif dan inovatif mengemas dan menyampaikan masing-masing sesi melalui berbagai media pembelajaran kreatif. Umpan balik dari pemahaman materi minggu sebelumnya dapat dilihat dari foto atau video aktivitas yang dikirimkan melalui grup whatssapp orang tua. Kurikulum pengajaran menyesuaikan kalender akademik semester genap jenjang sekolah dasar, yaitu bulan Januari-Juni. Pada 2 (dua) bulan awal hanya kurang dari 20% anak memberikan umpan balik, namun pada bulan Maret-Mei jumlah umpan balik mengalami peningkatan. Meskipun ibadah anak saat ini dilakukan secara daring, melalui pendampingan sesi aktivitas yang dikemas secara kreatif untuk mendukung tema ibadah, diharapkan menjadikan anak-anak lebih aktif, interaktif, meningkatnya motivasi belajar dan tentu saja meningkatkan kreativitas anak.
PEMBINAAN OLIMPIADE MATEMATIKA DI SMP NEGERI 4 KOTA SUNGAI PENUH
Authors: Patmala Kiki , Aien Nurul , Nada Nabillah Qatrun , Salmila Yepa , Anggraini Reri Seprina 
Published: August 2023

Kegiatan pembinaan olimpiade matematika dilaksanakan di SMP Negeri 4 Kota Sungai Penuh. Kegiatan ini diikuti oleh siswa yang memiliki minat dan potensi di bidang matematika. Pembinaan dilakukan selama 3 kali pertemuan. Kegiatan pembinaan ini terangkum dalam 3 tahapan yaitu pre test, treatment, dan post test. Metode pelaksanaan pada kegiatan pengabdian kepada masyarakat ini menggunakan metode ceramah, diskusi, presentasi. Pada hasil post test yang diberikan, menunjukkan bahwa 7 orang siswa memperoleh nilai 10-20. Hal tersebut dikarenakan beberapa siswa tidak mengikuti proses pembinaan secara keseluruhan.
Dynamics of the transport of total suspended sediments in the Mefou watershed at Nkolbisson-Yaounde
Authors: Choumele Jiague Ronny Roy , Kengni Lucas , Fouepe Takounjou Alain 
Published: August 2023

Abstract

This study carried out in the Mefou watershed aimed to assess the quantity of suspended solids in suspension. For this study, a water level gauge was installed at the main station at Etoud, four discharge measurements representing the seasons were carried out and water samples were collected. The maximum liquid discharge to the Lake Mefou was 3.92 m3/s observed during the long rainy season, while the minimum observed during the long dry season was 0.58 m3/s. Meanwhile, the maximum solid discharge to the Lake Mefou observed during the short rainy season was 598.8 mg/s and the minimum of 14.85 mg/s was observed in June during the short dry season. It is then evident that the amount of suspended sediments in the river is not proportional to the flow rate. The mobilization of solid particles in the watershed resulted in an annual total flux of 5.74 T/year into the lake reservoir. This result is not yet alarming for the reservoir lifespan but testify to the permanent activity of erosion in this environment caused by the combination of various natural and anthropogenic processes such as climate change and land use activities.
Medical Imaging Technology, 3D Printing and Medical Applications
Authors: Kauthankar Akshada 
Published: August 2023

Background:
3-dimensional (3D) printing denotes the various techniques, which are used to manufacture 3D anatomical from the patient data that is acquired. These models are rapidly gaining popularity in the medical community. Medical imaging modalities such as Computed Tomography (CT), Magnetic resonance imaging (MRI) and even ultrasonography have been used to assist in the manufacturing of 3D models. Currently, 3D printing has various medical applications, which includes pre-surgical planning, intra-operative planning, simulation models, manufacture of prosthesis and surgical tools.

Methods:
The PubMed database was searched for articles on 3D printing and applications of 3D printing. Relevant articles with basic physics, applications, advantages, and limitations were included in the study. The studies considered were dated from 2012 to 2022.

Conclusion:
3D printing is rapidly gaining popularity in the medical field due to its numerous applications. 3D printed equipment has various advantages, such as better fit due to customized implants, better patient comfort along with lesser manufacturing cost. Simulation models, Preoperative and intra-operative models help in guiding the surgeons during the surgery as well as deciding appropriate approaches for a better surgical outcome and success.