bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory modality profiles of antonyms
Authors: van de Weijer Joost , Bianchi Ivana , Paradis Carita 
Published: June 2023

AbstractAdjectives that are used to describe sensory experiences are often used to express more than one modality. The adjective sweet, for instance, may primarily be associated with taste (i.e., taste is the dominant modality of sweet), but it can also be used for smell, sound or sight, and possibly even for touch. It has also been shown that some sensory modalities combine more easily than others. Many adjectives that are used to describe taste, for instance, can also be used for smell, but, less likely, for sound. These associations between sensory modalities as they are expressed in language are the topic of this study. We looked at the distribution of the combinations of dominant modalities in pairs of antonymic sensory adjectives (e.g., sweet–sour), and how the dominant modality of the adjectives in these pairs differed from that of the adjectives in isolation. In our dataset, there was a sizeable number of pairs consisting of adjectives with differing dominant modalities. Within those pairs, we observed that adjectives with the dominant modality sight can also be used for touch and vice versa. Similarly, adjectives with the dominant modality of smell can also be used for taste and vice versa. Finally, adjectives with the dominant modalities sight and touch can both also be used for hearing and for taste, but not the other way around. These results contribute to our understanding of how language is used to describe sensory experiences, and, with that, how sensory experiences may be shaped by the words that we use to describe them.
Religion or Race? Using Intersectionality to Examine the Role of Muslim Identity and Evaluations on Belonging in the United States
Authors: d’Urso Amanda Sahar , Bonilla Tabitha 
Published: June 2023

AbstractHow do White Americans evaluate the politics of belonging in the United States across different ethnoreligious identity categories? This paper examines this question through two competing frameworks. On the one hand, given the salience of anti-Muslim attitudes in the United States, we consider whether White Americans penalize Muslim immigrants to the United States regardless of their ethnoracial background. On the other hand, Muslim identity is often conflated by the general public with Middle Eastern and North African (MENA) ethnoracial identity. We argue MENA-Muslim identity should be understood through the lens of intersectionality. In this case, White Americans may penalize MENA-Muslims immigrants to the United States more than Muslims from other ethnoracial groups. We test these two frameworks through a conjoint experimental design wherein respondents are asked to evaluate immigrants and indicate to whom the United States should give a green card—signaling legal belonging—and how likely the immigrant is to assimilate into America—signaling cultural belonging. Although White Americans believe White Muslims may assimilate better to the United States relative to MENA-Muslims, race does not moderate how White Americans evaluate who should be allowed to belong in the United States.
Early and mid-term outcomes of double-chambered right ventricle repair: An 8-year experience
Authors: Halder Vikram , Ghosh Soumitra , Thingnam Shyam Kumar Singh , Singh Harkant , Mishra Anand Kumar , Mahajan Sachin , Kumar Rupesh , Aggarwal Pankaj , Dutta Aduri Raja Suman , Mishra Amit 
Published: June 2023

AbstractBackground/Aim:Double-chambered right ventricle is a rare and progressive condition that is characterised by obstruction of the right ventricular tract. Double-chambered right ventricle is usually associated with ventricular septal defect. Early surgical intervention is recommended in patients with these defects. Based on this background, the present study aimed to review early and midterm outcomes of primary repair after double-chambered right ventricle.Methods:Between January 2014 and June 2021, 64 patients with a mean age of 13.42 ± 12.31 years underwent surgical repair for double-chambered right ventricle. The clinical outcomes of these patients were reviewed and assessed retrospectively.Results:An associated ventricular septal defect was present in all the recruited patients; 48 (75%) patients of sub-arterial type, 15 (23.4%) of perimembranous, and 1 (1.6%) patient of muscular type. The patients were followed up for a mean period of 46.73 ± 27.37 months. During their follow-up, a significant decrease in the mean pressure gradient from 62.33 ± 5.52 mmHg preoperatively to 15.73 ± 2.94 mmHg postoperatively was observed (p < 0.001). Notably, there were no hospital deaths.Conclusions:The development of double-chambered right ventricle in association with ventricular septal defect results in an increased pressure gradient within the right ventricle. The defect needs correction in a timely manner. In our experience, the surgical correction of double-chambered right ventricle is safe and shows excellent early and mid-term results.
The Influence of Database Characteristics on the Internal Consistency of Predictive Models of Trace Element Partitioning for Clinopyroxene, Garnet, and Amphibole
Authors: Cung Erica W. , Ustunisik Gokce K. , Wolf Aaron S. , Nielsen Roger L. 
Published: June 2023

AbstractUnderstanding the processes that produce the major and trace element signature of igneous materials requires quantitative models of the behavior of trace elements under the full range of natural conditions. Such predictive models are based on the results of laboratory experiments used to calibrate expressions via regression analysis. The predictive accuracy of those expressions depends on the number of experiments where a specific element was measured and the analytical precision/accuracy of the measurements, together with models that accommodate the known dependencies. A factor that has rarely been considered in such models is the “coverage” with respect to the range of composition, pressure, and temperature in the experimental data. The goal of this research is to evaluate how partition coefficients (Di) for clinopyroxene, amphibole, and garnet correlate with a variety of intensive and compositional variables for minerals with different substitution mechanisms. Our results show that the number of experimental determinations, even within a group of elements that behave systematically (e.g., REE), may vary by as much as a factor of five. Further, there are significant differences in the average composition, temperature, and pressure of the experimental database for each element. In addition, the combination of database differences and analytical precision for each element result in systematic differences in the magnitude of the controlling parameters. All of these factors impact the predictive power of the regressions on which we rely and can produce a bias in the predicted behavior that may be correlated with analytical error or average composition of the experiments.
Stepwise Widening of the Central Andes—The Role of the Lower Crust
Authors: Wang Huilin , Currie Claire A. 
Published: June 2023

AbstractThe outward growth of many orogens occurs through pulsed migration of the strain front. During Cenozoic shortening of the central Andes, the strain front abruptly migrated ∼400 km eastward across the Altiplano, isolating the plateau interior from major deformation. In contrast to the traditional critical wedge model that focuses on shallow crust deformation, our lithosphere‐scale numerical models show the ductile lower crust plays a key role in the dynamics of the orogen. As the orogen grows upward, the lower crust flows outward and causes stepwise expansion of the orogen through landward‐migrating deformation. The step length of the strain‐front migration increases with decreasing lower crustal strength. Topographically, a weaker crust promotes the formation of a smooth plateau and underthrusting of stronger foreland lithosphere. Our results indicate that the seemly unrelated physiography, deep‐lithosphere structure, and plateau‐wide strain migration in the Altiplano may all be the result of a weak lower crust.
Growth rate is a dominant factor predicting the rhizosphere effect
Authors: López José L , Fourie Arista , Poppeliers Sanne W M , Pappas Nikolaos , Sánchez-Gil Juan J , de Jonge Ronnie , Dutilh Bas E 
Published: June 2023

Abstract
The root microbiome is shaped by plant root activity, which selects specific microbial taxa from the surrounding soil. This influence on the microorganisms and soil chemistry in the immediate vicinity of the roots has been referred to as the rhizosphere effect. Understanding the traits that make bacteria successful in the rhizosphere is critical for developing sustainable agriculture solutions. In this study, we compared the growth rate potential, a complex trait that can be predicted from bacterial genome sequences, to functional traits encoded by proteins. We analyzed 84 paired rhizosphere- and soil-derived 16S rRNA gene amplicon datasets from 18 different plants and soil types, performed differential abundance analysis, and estimated growth rates for each bacterial genus. We found that bacteria with higher growth rate potential consistently dominated the rhizosphere, and this trend was confirmed in different bacterial phyla using genome sequences of 3270 bacterial isolates and 6707 metagenome-assembled genomes (MAGs) from 1121 plant- and soil-associated metagenomes. We then identified which functional traits were enriched in MAGs according to their niche or growth rate status. We found that predicted growth rate potential was the main feature for differentiating rhizosphere and soil bacteria in machine learning models, and we then analyzed the features that were important for achieving faster growth rates, which makes bacteria more competitive in the rhizosphere. As growth rate potential can be predicted from genomic data, this work has implications for understanding bacterial community assembly in the rhizosphere, where many uncultivated bacteria reside.
A dorsomedial prefrontal cortex-based dynamic functional connectivity model of rumination
Authors: Kim Jungwoo , Andrews-Hanna Jessica R. , Eisenbarth Hedwig , Lux Byeol Kim , Kim Hong Ji , Lee Eunjin , Lindquist Martin A. , Losin Elizabeth A. Reynolds , Wager Tor D. , Woo Choong-Wan 
Published: June 2023

AbstractRumination is a cognitive style characterized by repetitive thoughts about one’s negative internal states and is a common symptom of depression. Previous studies have linked trait rumination to alterations in the default mode network, but predictive brain markers of rumination are lacking. Here, we adopt a predictive modeling approach to develop a neuroimaging marker of rumination based on the variance of dynamic resting-state functional connectivity and test it across 5 diverse subclinical and clinical samples (total n = 288). A whole-brain marker based on dynamic connectivity with the dorsomedial prefrontal cortex (dmPFC) emerges as generalizable across the subclinical datasets. A refined marker consisting of the most important features from a virtual lesion analysis further predicts depression scores of adults with major depressive disorder (n = 35). This study highlights the role of the dmPFC in trait rumination and provides a dynamic functional connectivity marker for rumination.
Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors
Authors: Adu-Berchie Kwasi , Brockman Joshua M. , Liu Yutong , To Tania W. , Zhang David K. Y. , Najibi Alexander J. , Binenbaum Yoav , Stafford Alexander , Dimitrakakis Nikolaos , Sobral Miguel C. , Dellacherie Maxence O. , Mooney David J. 
Published: June 2023

AbstractAlthough adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a hydrogel that locally delivers adoptively transferred T cells to the tumor site while recruiting and activating host antigen-presenting cells with GMCSF or FLT3L and CpG, respectively. T cells alone loaded into these localized cell depots provided significantly better control of subcutaneous B16-F10 tumors than T cells delivered through direct peritumoral injection or intravenous infusion. T cell delivery combined with biomaterial-driven accumulation and activation of host immune cells prolonged the activation of the delivered T cells, minimized host T cell exhaustion, and enabled long-term tumor control. These findings highlight how this integrated approach provide both immediate tumor debulking and long-term protection against solid tumors, including against tumor antigen escape.
Adolescent leisure reading and its longitudinal association with prosocial behavior and social adjustment
Authors: Lenhart Jan , Richter Tobias , Appel Markus , Mar Raymond A. 
Published: June 2023

Abstract
Reading is a popular leisure activity for children, teenagers, and adults. Several theories agree that reading might improve social cognition, but the empirical evidence remains tentative, with research on adolescents especially lacking. We employed a very large, and nationally representative, longitudinal dataset from the National Educational Panel Study (NEPS) in Germany to examine this hypothesis. Specifically, we tested whether reading prospectively predicted future self-reported prosocial behavior and social adjustment in adolescents, controlling for a number of covariates. Two-way cross-lagged panel analyses probed the longitudinal relationship between leisure reading and these social outcomes from Grade 6 to Grade 9. In addition, we examined the effect of cumulative reading experience across Grades 5–8 on future social outcomes, using structural equation modeling. We also explored the unique contributions of cumulative reading experience in different literary genres (classic literature, popular literature, nonfiction, comic books). Cumulative reading in general did not predict future prosocial behavior and social adjustment. However, cumulative reading of modern classic literature was positively associated with later prosocial behavior and social adjustment.

Protocol registration
The stage 1 protocol for this Registered Report was accepted in principle on 08 November 2021. The protocol, as accepted by the journal, can be found at: https://doi.org/10.17605/OSF.IO/KSWY7.
Inhibition of cell cycle-dependent hyphal and biofilm formation by a novel cytochalasin 19,20‑epoxycytochalasin Q in Candida albicans
Authors: Watchaputi Kwanrutai , Jayasekara L. A. Channa Bhathiya , Ratanakhanokchai Khanok , Soontorngun Nitnipa 
Published: June 2023

AbstractBiofilm-mediated drug resistance is a key virulence factor of pathogenic microbes that cause a serious global health threat especially in immunocompromised individuals. Here, we investigated the antihyphal and antibiofilm activity of 19,20‑epoxycytochalasin Q (ECQ), a cytochalasin actin inhibitor isolated from medicinal mushroom Xylaria sp. BCC1067 against Candida albicans. Remarkably, 256 µg/ml of ECQ inhibited over 95% of C. albicans hyphal formation after 24 h-treatment. Combined ECQ and lipid-based biosurfactant effectively enhanced the antihyphal activity, lowering required ECQ concentrations. Hyphal fragmentation and reduction of biofilm biomass, shown by SEM and AFM visualization of ECQ-treated biofilms, were well corelated to the reduced metabolic activities of young and 24 h-preformed C. albicans biofilms. Induced intracellular accumulation of reactive oxygen species (ROS) also occurred in accompany with the leakage of shrunken cell membrane and defective cell wall at increasing ECQ concentrations. Transcriptomic analyses via RNA-sequencing revealed a massive change (> 1300 genes) in various biological pathways, following ECQ-treatment. Coordinated expression of genes, associated with cellular response to drugs, filamentous growth, cell adhesion, biofilm formation, cytoskeleton organization, cell division cycle, lipid and cell wall metabolisms was confirmed via qRT-PCR. Protein–protein association tool identified coupled expression between key regulators of cell division cyclin-dependent kinases (Cdc19/28) and a gamma-tubulin (Tub4). They coordinated ECQ-dependent hyphal specific gene targets of Ume6 and Tec1 during different phases of cell division. Thus, we first highlight the antihyphal and antibiofilm property of the novel antifungal agent ECQ against one of the most important life-threatening fungal pathogens by providing its key mechanistic detail in biofilm-related fungal infection.
Formerly bile-farmed bears as a model of accelerated ageing
Authors: Kalogeropoulu Szilvia K. , Rauch-Schmücking Hanna , Lloyd Emily J. , Stenvinkel Peter , Shiels Paul G. , Johnson Richard J. , Fröbert Ole , Redtenbacher Irene , Burgener Iwan A. , Painer-Gigler Johanna 
Published: June 2023

AbstractBear bile-farming is common in East and Southeast Asia and this farming practice often results in irreversible health outcomes for the animals. We studied long-term effects of chronic bacterial and sterile hepatobiliary inflammation in 42 Asiatic black bears (Ursus thibetanus) rescued from Vietnamese bile farms. The bears were examined under anesthesia at least twice as part of essential medical interventions. All bears were diagnosed with chronic low-grade sterile or bacterial hepatobiliary inflammation along with pathologies from other systems. Our main finding was that the chronic low-grade inflammatory environment associated with bile extraction in conjunction with the suboptimal living conditions on the farms promoted and accelerated the development of age-related pathologies such as chronic kidney disease, obese sarcopenia, cardiovascular remodeling, and degenerative joint disease. Through a biomimetic approach, we identified similarities with inflammation related to premature aging in humans and found significant deviations from the healthy ursid phenotype. The pathological parallels with inflammageing and immuno-senescence induced conditions in humans suggest that bile-farmed bears may serve as animal models to investigate pathophysiology and deleterious effects of lifestyle-related diseases.
Evaluating the use of a balance prosthesis during balance perturbations in children and young adults with cochleovestibular dysfunction
Authors: Benjamin Rebecca S. , Cushing Sharon L. , Blakeman Alan W. , Campos Jennifer L. , Papsin Blake C. , Gordon Karen A. 
Published: June 2023

AbstractStudy objectives were to: (1) quantify stability in children and young adults using cochlear implants with concurrent cochleovestibular dysfunction (CI-V) during balance perturbations and (2) to assess effects of an auditory head-referencing device (BalanCI) on their stability. The BalanCI provides auditory feedback via cochlear implants to cue posture and potentially avoid falling in children with CI-V. It was hypothesized that children and young adults with CI-V respond with larger movements to floor perturbations than typically-developing peers (controls) and that BalanCI use decreases these movements. Motion in response to treadmill perturbations was captured by markers on the head, torso, and feet in eight CI-V and 15 control participants. Stability (area under the curve of motion displacement) and peak displacement latencies were measured. The CI-V group demonstrated less stability and slower responses than the control group during medium and large backwards perturbations (p’s < 0.01). In the CI-V group, BalanCI use improved stability during large backwards perturbations (p < 0.001), but worsened stability during large sideways perturbations (p’s < 0.001). Children and young adults with CI-V move more to remain upright during perturbations than typically-developing peers. The BalanCI has potential to aid physical/vestibular therapy in children with CIs who have poor balance.
Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
Authors: Martínez-Nicolás Israel , Martínez-Sánchez Francisco , Ivanova Olga , Meilán Juan J. G. 
Published: June 2023

AbstractAge-related cognitive impairment have increased dramatically in recent years, which has risen the interes in developing screening tools for mild cognitive impairment and Alzheimer's disease. Speech analysis allows to exploit the behavioral consequences of cognitive deficits on the patient's vocal performance so that it is possible to identify pathologies affecting speech production such as dementia. Previous studies have further shown that the speech task used determines how the speech parameters are altered. We aim to combine the impairments in several speech production tasks in order to improve the accuracy of screening through speech analysis. The sample consists of 72 participants divided into three equal groups of healthy older adults, people with mild cognitive impairment, or Alzheimer's disease, matched by age and education. A complete neuropsychological assessment and two voice recordings were performed. The tasks required the participants to read a text, and complete a sentence with semantic information. A stepwise linear discriminant analysis was performed to select speech parameters with discriminative power. The discriminative functions obtained an accuracy of 83.3% in simultaneous classifications of several levels of cognitive impairment. It would therefore be a promising screening tool for dementia.
Discovery of a new Hepatozoon species namely Hepatozoon viperoi sp. nov. in nose-horned vipers in Türkiye
Authors: Ceylan Onur , Úngari Letícia Pereira , Sönmez Gonca , Gul Cigdem , Ceylan Ceylan , Tosunoglu Murat , Baycan Bengi , O’Dwyer Lucia Helena , Sevinc Ferda 
Published: June 2023

AbstractAlthough Hepatozoon spp. remains the most prevalent intracellular protozoa infecting snakes, it was reported only in a few snake species of the Colubridae family in Türkiye. Moreover, studies on these hemoparasites are not available in venomous nose-horned vipers from Türkiye. In this study, we investigated Hepatozoon spp. in three individual Vipera ammodytes using morphological and molecular methods. Our results were positive for intraerythrocytic Hepatozoon spp. gamonts in all three snakes, exhibiting low parasitemia. The microscopic findings were further confirmed through molecular data. A genus-specific PCR assay targeting the 18S rRNA gene region of Hepatozoon spp., was performed using HemoF/HemoR and Hep300/Hep900 primers. The obtained sequences were concatenated and used in phylogenetic analyses in comparison with different Hepatozoon species. Although our (OP377741) isolate was separated into a different branch, it was clustered with the isolates of H. massardi (KC342526), H. cevapii (KC342525), and H. annulatum (ON262426) from Brazilian snakes. Moreover, gene similarity and pair-wise distance between our isolate and other Hepatozoon species infecting snakes were found to be 89.30–98.63% and 0.009–0.077, respectively. Hence, we reported a new species of Hepatozoon, namely Hepatozoon viperoi sp. nov. infecting V. ammodytes. Since the literature does not indicate the existence of such a Hepatozoon species in V. ammodytes in different countries, our data may contribute to the expanding knowledge of Hepatozoon species in snakes, providing new insights into the biodiversity of the haemogregarine protozoan parasite.