bluuebunny/crossref_metadata_2025_split huggingface dataset:
Earlier Age at Type 2 Diabetes Diagnosis Is Associated with Increased Genetic Risk for Cardiovascular Disease
Authors: Lee Hyunsuk , Choi Jaewon , Kim Na Yeon , Kim Jong-Il , Moon Min Kyong , Lee Seunggeun , Park Kyong Soo , Kwak Soo Heon 
Published: March 2023

<p> </p>
<p><em><strong>Objective: </strong></em>We investigated genetic risk for cardiovascular disease (CVD) by type 2 diabetes (T2D) diagnosis age.</p>
<p><em><strong>Research Design and Methods: </strong></em>We compared incident CVD events by T2D diagnosis age using UK Biobank (N=12,321) and Seoul National University Hospital (SNUH) cohort (N=1,165). Genetic risk was quantified using polygenic risk score (PRS).</p>
<p><em><strong>Results: </strong></em>People with earlier T2D diagnosis had higher CVD risk. In UK Biobank, effect size of coronary artery disease (CAD) PRS on incident CAD was largest in people diagnosed of T2D at ages 30-39 (hazard ratio 2.25, 95% CI 1.56-3.26) and decreased for later-onset: 1.51 (1.30-1.75) at 40-49, 1.36 (1.24-1.50) at 50-59, and 1.30 (1.14-1.48) at 60-69 (<em>P</em>interaction=0.0031). Similar trend was observed in SNUH cohort. This increased genetic risk associated with earlier T2D diagnosis was largely mitigated by healthy lifestyle.</p>
<p><em><strong>Conclusion: </strong></em>People with earlier T2D diagnosis have higher CAD genetic risk, and this could be used to tailor lifestyle intervention.</p>
The problem of lexical and syntactic coordination in the conceptions of S. G. Ilyenko and V. V. Stepanova
Authors: Мартьянова И.А. 
Published: March 2023

Статья посвящена исследованию лексико-синтаксической координации в русистике. Анализируются основные положения концепций С. Г. Ильенко и В. В. Степановой, их развитие в статьях членов проблемных групп кафедры русского языка Герценовского университета. Критически оценивается современное состояние изучения лексико-синтаксической координации, определяются перспективы ее дальнейшего исследования. Ключевые слова: лексико-синтаксическая координация, синтаксическая лексикализация, фразеологизация, идентификация, лексико-композиционная взаимосвязь
The article focuses on the Russian studies of lexical-syntactic coordination. The author analyzes the main provisions of S. G. Ilyenko and V. V. Stepanova’s conceptions, their development in the papers of the members at the Department of the Russian Language, Herzen State Pedagogical University. The current state of studying the lexical-syntactic coordination is critically assessed, and the prospects for its further research are determined.
The theme of civilization crisis in the short story "England, My England" by D. H. Lawrence
Authors: Норец М.В. , Кислицына Н.Н. 
Published: March 2023

Раскрытию проблемы разрушения цивилизации посвящена новелла Д. Г. Лоуренса “England, My England”. Поиск направлений самоопределения в литературе встречается довольно часто: личностного самоопределения, себя в этом мире и идеального общества. Новелла Д. Г. Лоуренса “England, My England” была написана автором в тяжелые времена Британской истории: Первая мировая война, разруха и бедность населения, формирование Соединенного Королевства Великобритании и Северной Ирландии. Все эти процессы волновали не только историков и политологов, а также нашли свое отражение в литературе этого периода.
D. H. Lawrence's short story "England, My England" considers the problem of the civilization destruction. The search for directions of self-determination in literature is quite common: personal self-determination, finding oneself in this world and an ideal society. D. H. Lawrence's short story "England, My England" was written by the author during the difficult times of British history: the First World War, devastation and poverty of the population, the formation of the United Kingdom of Great Britain and Northern Ireland. All these processes were of concern not only to historians and political scientists, but were also reflected in the literature of this period.
Specificity of song precedent statements in the prose by V. Tokareva
Authors: Киреева Ю.Н. , Гореликова О.Н. 
Published: March 2023

В статье анализируются многочисленные и разнообразные включения песенных прецедентных высказываний в ткань художественных текстов В. Токаревой. Усиливая экспрессивность текста, песенные фрагменты репрезентируют определенные идейно-методологические установки автора и отражают современную аксиологическую картину мира. Отмечено, что песенные прецедентные тексты помогают детализировать образ, передать внутреннее состояние героя, наиболее полно описать ситуацию, а также выразить авторскую позицию. Отдельные прецедентные включения позволяют достичь юмористического эффекта. Оказавшись в новом контекстном окружении, песенные строки могут изменять исходную эмотивно-оценочную сторону высказывания.
The article analyzes various inclusions of song precedent statements in prose by V. Tokareva. Song lines enhance the expressiveness of the text, reflect certain writing features of prose and reveal the modern axiological picture of the world. Precedent song texts help to detail the image, convey the inner state of the character, describe the situation most fully and express the author's position. Some statements allow achieving a humorous effect. Song lines in a new context can change the emotive-evaluative side.
Экологическая структура сообщества макроводорослей на западе Крыма
Authors: Evstigneeva I.K. , Tankovskaya I.N. 
Published: March 2023

A study of the macrophytobenthos off the western coast of Crimea in the area from Cape Tyubek to Yazykovaya Balka showed the presence of 12 ecological groups of algae. The marine, dominant, annual and oligosaprobic groups are characterized by the highest species diversity, which is typical of the Black Sea phytobenthos. Chlorophyta is an ecologically distinct group dominated by brackish-marine, mesosaprobic and rare species that rank second in other divisions. The extreme values of numbers of species in the ecogroups occur in areas of the coastal zone with varying activity of abrasion and landslide processes and anthropogenic interference. Species diversity and floristic composition of ecogroups are subject to spatial transformation even though their ratio is stable. The observed dominance of oligosaprobionts, the abundance of mesosaprobionts and the low number of polysaprobionts correspond to their proportions in the pristine marine areas. However, the values of the floristic and saprobiological coefficients show that the quality of the environment in the study area is close to mesotrophic.
Исследование макрофитобентоса у западного берега Крыма на участке от мыса Тюбек до Языковой балки показало, что в его состав входят водоросли 12 экологических групп. Наибольшим видовым разнообразием характеризуют- ся морская, ведущая, однолетняя и олигосапробная группы, что типично для черноморского фитобентоса. Экологическим своеобразием отличается Chlorophyta, в котором доминиру- ют солоноватоводно-морские, редкие и мезосапробные виды, занимающие в других отделах вторую позицию. Крайние зна- чения числа видов в экогруппах приходятся на участки при- брежной зоны с разной активностью абразионно-оползневых процессов и антропогенного вмешательства. Видовое раз- нообразие и флористический состав экогрупп подвержены пространственной трансформации, но их соотношение ста- бильно. Выявленное доминирование олигосапробионтов, многочисленность мезосапробионтов и малая доля полиса- пробионтов соответствует их пропорции на чистых морских участках. Однако величины флористического и сапробиоло- гического коэффициентов показывают, что качество среды в районе исследований приближается к мезотрофному.
Особенности экологии и биологии размножения сизоворонки Coracias garrulus L., 1758 в Ставропольском крае
Authors: Malovichko L.V. , Poddubnaya N.Ya. , Kulakov D.V. 
Published: March 2023

The results of study of the ecology and biology of the European Roller in the Stavropol Region during the period of agricultural transformation of the environment in 1984–2019 are presented. Favorable conditions for this bird species are found in steppe areas used for grazing animals and on non-irrigated arable land. Rollers nest mainly in holes in natural cliffs (46.9% of the total number of nests) and cliffs of anthropogenic origin (37.4%), as well as in tree hollows (15.7%). The nesting period of the population (the time of pairing, nest building, egg laying, development, and growth of nestlings, and feeding of nestlings) has characteristics that are associated with traditional agriculture. At the same time, the largest clutch size known for European populations, of seven eggs was found, and the eggs were somewhat smaller than in most of the range. The average clutch size (4.43 ± 0.17 eggs) and brood size (3.43 ± 0.13 chicks) correspond to the range optimum. The breeding success is 77.5%. A cautious assumption is made that the increase in clutch size and decrease in egg size may be an adaptive response of the species to changes in habitat in the last 30–50 years.
В статье представлены результаты изучения эко- логии и биологии сизоворонки Ставропольского края в период сельскохозяйственной трансформации среды 1984–2019 гг. Благоприятные условия для жизни птицы находят в степных участках для выпаса животных и на неорошаемых пахотных землях. Сизоворонки селятся преимущественно в норах естественных обрывов (46.9% от общего числа гнезд) и обрывов антропогенного происхождения (37.4%), а также в дуплах (15.7%). Гнездовая жизнь популяции (время образования пар, постройки гнезд, откладки яиц, развития и роста птенцов и питание птенцов) имеет видовые характеристики периода традиционного сельского хозяйства. Одновременно обнаружен самый большой для европейских популяций размер кладки из 7 яиц, а сами яйца несколько мельче, чем на большей части ареала. Средние значения размера кладки (4.43 ± 0.17 яиц) и выводка (3.43 ± 0.13 птенцов) соответствуют оптимуму ареала. Успешность размножения составляет 77.5%. Сделано осторожное предположение о том, что увеличение размера кладки и уменьшение размера яиц может быть адаптивной реакцией вида на изменения среды обитания в последние 30–50 лет. Ключевые слова: адаптация, поведение, проблемы сохранения биоразнообразия, редкие и угрожаемые виды, скорость изменения среды
A systematic review of allergen immunotherapy, a successful therapy for canine atopic dermatitis and feline atopic skin syndrome
Authors: Mueller Ralf S. 
Published: March 2023

Abstract
Canine atopic dermatitis and feline atopic skin syndrome are common presentations in small animal practice. Numerous drugs are used for symptomatic therapy. The only definitive treatment based on the cause of the disease is allergen immunotherapy. Classical allergen immunotherapy (AIT) consists of subcutaneous injections of an extract containing offending allergens, with increasing doses and allergen concentrations at short intervals during the induction phase of several weeks to months followed by a maintenance phase, where a fixed dose is typically given at longer intervals. Dose and interval are tailored to the individual patient. Newer types of AIT include rush immunotherapy, where the induction phase is abbreviated, intralymphatic immunotherapy, and oromucosal or sublingual immunotherapy. AIT aims at inducing a regulatory T-cell response and subsequently downregulating the exaggerated immune response to offending allergens leading to clinical signs. This article reviews the published knowledge about allergen immunotherapy in dogs and cats for small animal practitioners.
International Legal Aspects of the Asteroid Threat Prevention
Authors: Trumpel Valeria K. 
Published: March 2023

More than 900 discovered near-earth objects (NEOs), which size exceeds 140 meters, are designated as potentially hazardous natural objects (PHNOs), in other words asteroids and comets which can be a threat to Planet Earth. Experts believe that the total amount of PHNOs consists of more than 6000 objects.The existing factors such as the active media coverage, the states’ and international organizations’ attention and the public interest provoke the urgency of the asteroid threat issue. Due to baffling complexity of this problem and expensiveness of projects considering its solution the goal of prevention of the asteroid threat can be accomplished only with the consolidated efforts of the whole international community.The article concentrates on the main directions of international cooperation in the sphere of the asteroid threat prevention. The international policy concerning the NEO hazard can be divided into four groups:detection, observation and exploration of NEOs;development and use of interception, deviation and destruction measures to the PHNOs;monitoring and warning of the PHNOs;informational and educational work.
CLINICAL IMMUNOLOGY AND ALLERGOLOGY AS AN IMPORTANT COMPONENT OF CONTINUOUS MEDICAL EDUCATION OF DOCTORS
Authors: Havrylyuk Anna , Zubchenko Svitlana , Chopyak Valentyna 
Published: March 2023

The science of clinical immunology and allergology is constantly developing. Every year, new opportunities open up in the fields of immuno-, allergy diagnostics, and immunotherapy. The teaching of these disciplines has been introduced in Ukrainian higher medical institutions for more than 25 years. However, the number of credits for these disciplines is, unfortunately, decreasing every year.
Aim. The research aims at analyzing modern achievements in the field of immunology and allergology as well as emphasizing the necessity and possibilities of their practical use by teachers at the departments of clinical immunology and allergology at medical universities.
Materials and Methods. Descriptive and methodological research techniques were used to write the article: several scientific sources were analyzed, which describe the latest achievements in practical immunology and allergology and their implementation in clinical and diagnostic work; the contents of educational programs and plans for teaching clinical immunology and allergology in higher educational institutions of Ukraine were processed in detail, using the example of the Department of Clinical Immunology and Allergology of the Danylo Halytsky National Medical University, several European educational institutions that train specialists in the "Medicine" specialty.
Results and Discussion. The analysis of theoretical data shows that doctors, clinical immunologists, allergists, and specialists of related disciplines increasingly use the developments of the latest molecular-biological and hybridoma technologies in daily practical activities, which enables personalized approaches to the diagnosis of diseases and targeted therapy. However, practicing doctors have progressively less time for deep study and detailed analysis of the mechanisms, theories, and technologies of modern immunology and allergology.
Conclusions. Solving this issue is possible through the integration of the mentioned latest achievements into the educational process at the stages of undergraduate and postgraduate education.
RISK FACTORS OF LIFE QUALITY REDUCTION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Dubas Vitalii 
Published: March 2023

It is a known fact that the presence of a chronic disease or chronic pain syndrome reduces the quality of life (QoL). Despite considerable achievements in the diagnostics and treatment of systemic lupus erythematosus (SLE) over the past decades and improvements in the long-term prognosis of patients, many challenges remain unsolved. The investigation of the quality of life can help to comprehensively evaluate patients' health, the effectiveness and safety of treatment and identify other causes of reduced quality of life that are not directly related to the disease.
Aim of the academic paper lies in evaluating quality of life parameters using the SF-36 questionnaire in patients with SLE and analyzing risk factors for its reduction.
Materials and Methods. A questionnaire was conducted using the Medical Outcomes Study Short Form 36 questionnaire (SF-36) of 36 patients with systemic lupus erythematosus aged 18 to 62 years, regardless of disease activity at the time of examination, and 24 practically healthy persons, comparable in age and gender ratio. The main parameters of the quality of life in the 2 groups were compared, as well as their dependence on clinical manifestations and therapy was studied.
Results and Dyscussion. Physical well-being in patients with SLE (29.6±2.97) is significantly lower (p<0.001) than in healthy individuals (55.8±3.31). The level of mental well-being does not differ significantly, but its components, such as social functioning (p=0.047) and vital activity (p=0.01) are reduced in patients with SLE. The level of physical well-being is lower in the groups of patients with the presence of arthritis (p=0.026), avascular necrosis of the femoral head before surgery (p=0.019) and skin rash (p=0.032) in the clinical picture compared to patients without these manifestations. The use of cyclophosphamide (p=0.046) and mycophenolate mofetil (p=0.012) is associated with a higher level of mental well-being.
Conclusions. Patients with SLE have a lower level of quality of life compared to healthy individuals of the corresponding age and gender. The risk factors for reducing the level of physical well-being are the presence of arthritis, skin rash and avascular necrosis of the femoral head (prior to surgical intervention). The level of mental well-being is significantly higher among patients taking cyclophosphamide and/or mycophenolate mofetil.
Abbreviations:
ACR - American College of Rheumatology
AIDS - acquired immunodeficiency syndrome
ANFH - avascular necrosis of femoral head
CF - Cyclophosphamide
EULAR - The European Alliance of Associations for Rheumatology
GC - glucocorticoids
MMF - Mycophenolate mofetil
SLE - systemic lupus erythematosus
SLICC - The Systemic Lupus Erythematosus International Collaborating Clinics
QoL - Quality of life
Implementasi Pengendalian Persediaan Bahan Baku Menggunakan Metode Economic Order Quantity (EOQ) pada Perusahaan Sohun di Kota Madiun
Authors: Andini Anggi Surya , Wiguna Ardhitya Alam , Djamali R. Abdoel , Pratama Fredy Eka Ardhi 
Published: March 2023

Penelitian ini bertujuan untuk menentukan banyaknya jumlah pembelian bahan baku tepung sagu yang optimal pada setiap kali pemesanan, kapan waktu yang tepat untuk melakukan pemesanan kembali (reorder point) bahan baku tepung sagu, dan berapa total biaya persediaan (total inventory cost) yang optimal untuk pengadaan bahan baku tepung sagu di Perusahaan Sohun Cap Mawar dengan menggunakan metode Economic Order Quantity (EOQ). Hasil analisis yang diperoleh menunjukkan bahwa dengan menggunakan Metode Economic Order Quantity (EOQ) jumlah kuantitas pembelian bahan baku tepung sagu yang optimal adalah sebanyak 24.649 kg pada setiap kali pesan dengan frekuensi pembelian bahan baku sebanyak 4 kali dalam satu tahun. Persediaan pengaman yang dihasilkan dengan metode EOQ yaitu sebesar 1.008 kg, dengan pemesanan ulang bahan baku tepung sagu ketika persediaan mencapai sebesar 1.658 kg. Total biaya persediaan bahan baku tepung sagu dengan menggunakan metode EOQ yaitu sebesar Rp 29.578.808.
EFEKTIVITAS KEGIATAN EMPLOYEE RELATIONS BANDAR DJAKARTA ALAM SUTERA DALAM MENINGKATKAN MOTIVASI KERJA KARYAWAN
Authors: Widiyanti Zahra Dias , Weynanda Arya Andhika 
Published: March 2023

This research examines the effectiveness of employee relations conducted by Bandar Djakarta Alam Sutera in increasing employee motivation. This research uses a descriptive qualitative method with a case study approach through interviews, observations and document studies. The research subjects were carried out by the Operational Manager, Head of Public Relations, and Head of Service and Bar. The results of the study found that employee relations activities were effective in increasing employee motivation. The phenomenon of this research departs from the condition felt by employees after the Covid-19 pandemic, namely experiencing a decrease in work motivation when they have to adapt again to open spaces. This is indicated by the number of employees who arrive late to the location and the level of quality and speed of service provided. So in this case, a special focus and strategy is needed in the form of employee relations in order to maintain service quality by managing a large number of employees. In this study, the authors explain how the implementation of employee relations activities at Bandar Djakarta Alam Sutera and how effective they are in increasing employee motivation. Implementation of employee relations activities goes according to Rosady Ruslan's description of employee relations, so it is very effective in increasing employee motivation.
Keywords: employee relations, work motivation, employee
OPINI PUBLIK MENGENAI ISU “SRI MULYANI MAU ORANG KAYA BAYAR PAJAK LEBIH BANYAK” DALAM MEDIA INSTAGRAM @narasinewsroom
Authors: Rafi Mochamad , Saragih Nurhayani , Astuti Sri Wahyuning 
Published: March 2023

The issue that has been developing in recent times is the issue of the policy of the minister of finance who wants to issue a policy that the rich must pay higher than before, this policy is taken in a step to deal with Indonesia's economic recovery which was previously sluggish due to Covid-19 pandemic. The purpose of this study is to analyze Positive public opinion, negative public opinion, and neutral on the post 'Sri Mulyani Mau Orang Kaya Bayar Pajak Lebih Banyak' in Instagram Media @narasinewsroom Period July 2, 2021 In this study, researchers used the concept of public opinion which has been categorized into opinion positive, negative, and neutral.In this study, the study population took all comments on the post "Sri Mulyani Wants Rich People to Pay More Taxes" on @narasinewsroom Instagram account as many as 526 and the sample in this study was 228 comments. The data collection technique uses random sampling techniques. in testing validity and reliability using reliability between coders using hostly formulas. The results showed that there were 82 positive opinions (36% of comments), negative opinions categories got 86 frequency results (38% of comments) and neutral opinions that got frequency results of 60 (26% comments).
Keywords: public relations, new media, public opinion
STRATEGI MEMBANGUN BRAND IMAGE DALAM MENINGKATKAN DAYA SAING LEMBAGA PENDIDIKAN
Authors: Zakaria Wahyu , Yuniati Ulfa , Puspitasari Euis Evi 
Published: March 2023

Brand Image is a compilation of assumptions in the minds of consumers regarding a brand. Building a brand image in a good educational institution has a competitive influence. Brand Image in an educational institution is one of the important steps in fulfilling the maximum reputation in the minds of the wider community.The research objectives are: 1) To find out the efforts made by the strategy to form a brand image in increasing the competitiveness of educational institutions at Tanjungsari State Agricultural Development Vocational School; 2) To find out how to maintain the existence of the brand image of agricultural education institutions; 3) To find out what are the supporters and obstacles to building a brand image in increasing the competitiveness of educational institutions at Tanjungsari State Agricultural Development Vocational School. This research uses a qualitative approach with a case study research design. This research uses data collection methods, namely Field Observations and Intensive-depth Interview. The technique of analyzing data is data reduction, data presentation, and data verification. To check the validity of the data, triangulation of sources is carried out and discussions with supervisors and colleagues are carried out. The results of the study focused on SMK PPN Tanjungsari in a strategy to build a brand image to increase the competitiveness of educational institutions in surgery with the theory of brand identity, brand personality, brand association , brand attitude & behavior, and brand benefit & competence.
Keywords: brand image, competitiveness, educational institutions, strategy