bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and evaluation of eco‐friendly carvacrol nanoemulsion as a sustainable biopesticide against bacterial leaf blight of cluster bean
Authors: Choudhary Pooja , Bhanjana Gaurav , Kumar Sandeep , Dilbaghi Neeraj 
Published: September 2023

AbstractBACKGROUNDThe study of carvacrol plant antibacterial components has recently become a hot topic in modern farming. Carvacrol industrial applications are restricted by their physicochemical instability and partial solubility in water. In the present study, an ultrasonic emulsification method was used to prepare a carvacrol nanoemulsion (CAR‐NE) employing nonionic surfactants. The CAR‐NE was characterized using a dynamic light scattering (DLS) instrument and transmission electron microscopy (TEM). The goal of this work was nanoencapsulation of carvacrol to improve its aqueous solubility and preservation of the encapsulated compound against climatic conditions. Another aim of the present study was the evaluation of the growth‐promoting effects and antibacterial potential of CAR‐NE against bacterial leaf blight of cluster bean.RESULTSCAR‐NE showed a hydrodynamic diameter, ZP and PDI index of 43.88 ± 4.30 nm, −47.8 ± 0.23 mV and 0.246 ± 0.04, respectively. The spherical shape morphology of CAR‐NE was confirmed by TEM imaging. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of the CAR‐NE were 20 and 160 μL mL−1 (respectively) against Xanthomonas axonopodis pv. cyamopsidis. Additionally, the antibacterial potential of CAR‐NE was evaluated for controlling bacterial blight of cluster bean in fields. The disease severity in the negative control plants (water) was 84%, but that in the CAR‐NE 160 (μL mL−1) was remarkably low at 14%, nearly the same as the positive control (streptomycin sulfate).CONCLUSIONThe shelf‐life of CAR‐NE was 2 months at room temperature without any appreciable changes in hydrodynamic diameter and zeta potential. Consequently, plants treated with CAR‐NE 160 showed substantial improvement in plant growth. © 2023 Society of Chemical Industry.
Balancing profit and sustainability: Investigating the eco‐innovation strategies of G20 polluting industries
Authors: Mahajan Alisha , Majumdar Kakali 
Published: September 2023

AbstractThe present study investigates the impact of environmental stringency and strategic behavior of G20 countries for the period of 1990–2019 using Porter and Pollution‐Haven hypotheses as frameworks to understand the potential for eco‐innovation or pollution‐paradises. Mediation Effect of Research and Development and Foreign Direct Investment are investigated between exports of environmentally sensitive goods and environmental stringency with DOLS method of estimation. Environmental Kuznets Curve (EKC) is used to analyze the relationship of growth and environmental degradation with reference to strategic behavior of the G20. Results show that majority of G20 countries are practicing the Porter Hypothesis. Overall, the findings suggest that sustainability is a critical consideration in balancing trade potential and environmental impact. The article offers a novel contribution to the field of environmental economics by comprehensively analyzing the connections between environmental regulations and strategic behaviors of the G20 countries with special reference to trade of sensitive goods.
Are entrepreneurs penalized during job searches? It depends on who is hiring
Authors: Ding Waverly W. , Lee Hyeun J. , Shapiro Debra L. 
Published: September 2023

AbstractResearch SummaryHow do job‐applicants with entrepreneurship experience—“post‐entrepreneurs”—fare in the wage labor job market? We propose an “entrepreneurship‐experience penalty” generally occurs yet varies in strength depending on the recruiters faced by post‐entrepreneurs in their job application process. In an experiment utilizing the selection‐decisions of 275 recruiters (experimental study participants) in reaction to objectively‐identical job‐applicants' resumes whose differences relate to whether their last‐held job was as a Founder or as an Executive, we found that: (a) resumes of Founders (compared to Executives) are about 23%–29% less likely to be picked as top‐choice for hire, (b) this entrepreneurship penalty is weaker for recruiters with (rather than without) entrepreneurial aspirations, and (c) this recruiter moderator‐effect is stronger for recruiters in smaller (rather than larger) firms.
Evaluation of the diagnostic accuracy of the serological test for paratuberculosis in cattle according to tuberculosis status
Authors: Jurado‐Martos Francisco , Cardoso‐Toset Fernando , Tarradas Carmen , Galán‐Relaño Ángela , Sánchez‐Carvajal José María , Ruedas‐Torres Inés , Vera‐Salmoral Eduardo , Larenas‐Muñoz Fernanda , Carrasco Librado , Gómez‐Laguna Jaime , Lorenzo Belén Huerta , Luque Inmaculada 
Published: September 2023

AbstractBackgroundEnzyme‐linked immunosorbent assays (ELISAs) are the most widely used diagnostic tools in bovine paratuberculosis (bPTB) control. However, their diagnostic accuracy may be compromised by bovine tuberculosis (bTB) infection, as both diseases share diagnostic targets.MethodsThe bPTB and bTB infection status of 228 animals was determined using microbiological tissue culture as a reference test. The diagnostic performance (sensitivity, specificity, likelihood ratios and predictive values) of the bPTB‐ELISA on blood serum samples, taking into account the bPTB animal‐level prevalence of the area and the bTB status of the animals, was evaluated.ResultsA sensitivity of 40.7% (95% confidence interval [CI]: 27.5%–53.9%) and a specificity of 94.7% (95% CI: 91.4%–98.0%) were obtained for bPTB‐ELISA in all animals. A bPTB‐ELISA‐positive animal would have a post‐test probability of 70% or more of being infected in areas with a bPTB prevalence of 23% or more. A negative bPTB‐ELISA result, in areas with a bPTB prevalence of 41% or less, would rule out the disease with more than 70% certainty. In bTB‐positive animals, sensitivity increased (94.4% [95% CI: 81.4%–100%] vs. 25.1% [95% CI: 11.8%–38.4%]) and specificity decreased (82.6% [95% CI: 71.8%–93.4%] vs. 99.4% [95% CI: 98.0%–99.9%]). The bPTB‐ELISA is a good tool to rule out bPTB co‐infection in bTB‐positive animals, while in bTB‐negative animals, it allows confirmation of disease with more than 70% probability if disease prevalence is 6% or more.LimitationsThe observed differences could be enhanced by the effect of frequent application of the intradermal tuberculin test, which was unknown in the animals studied.ConclusionsThese results provide useful guidance for the application and interpretation of ELISA as a tool for bPTB disease control.
The application advances of dendrimers in biomedical field
Authors: Li Longjie , Deng Yukai , Zeng Yonghui , Yan Bei , Deng Yulian , Zheng Ziyang , Li Siqi , Yang Yuhang , Hao Jinwei , Xiao Xianjin , Wang Xinyu 
Published: September 2023

AbstractDendrimers are a family of nano‐sized three‐dimensional polymers with unique dendritic branching structures and compact spherical geometries. In recent years, dendrimers have made a series of breakthroughs in the biomedical field. In this review, we introduce the synthesis principles, modification methods, and new materials designed based on dendrimers; discuss the importance of cytotoxicity of dendrimers for applications; and elaborate on their applications in the field of molecular assembly and cancer diagnosis and treatment. We speculate that in the near future, more new materials based on dendrimers will be applied in the biomedical field.
Prevalence of canine herpesvirus 1 and associated risk factors among bitches in Iranian breeding kennels and farms
Authors: Rezaei Mahdieh , Jajarmi Maziar , Kamani Saba , Khalili Mohammad , Babaei Homayoon 
Published: September 2023

AbstractBackgroundCanine herpesvirus 1 (CHV‐1) is an important cause of death in newborn puppies and of fertility problems in adult dogs. Identification of risk factors may help to reduce infection rates and alleviate concerns for dog owners and breeders. This study was designed to screen for CHV‐1 infection in bitches of breeding kennels and farms in Iran and relate this to possible risk factors.MethodsA total of 63 vaginal samples were collected from dogs in 5 breeding kennels (n = 47) and from 7 farms (n = 16). Real‐time polymerase chain reaction was used to detect the CHV‐1 specific glycoprotein B (gB) gene. Prevalence rates were evaluated in relation to various risk factors, including region, housing, vaccination, deworming, pregnancy, reproductive problems, number of dogs living together and hygiene conditions.ResultsIn total, 21 (33.3%) of 63 vaginal samples were positive for CHV‐1 DNA. The prevalence rate in farms (7/16; 43.7%) was higher than in kennels (14/47; 29.7%). No association was found between CHV‐1 prevalence and potential risk factors.ConclusionsCHV‐1 is highly prevalent in dogs in Iranian farms and kennels. Since the CHV1 vaccine is unlicensed in Iran, effective management strategies are essential to reduce the consequences of this pathogen.
Pflegebedürftigkeit in Deutschland
Authors: Matzk Sören , Tsiasioti Chrysanthi , Behrendt Susann , Jürchott Kathrin , Argüello Guerra Felipe , Schwinger Antje 
Published: September 2023

Zusammenfassung
Zusammenfassung
Der Beitrag liefert ein ausführliches Bild zum Stand der Pflegebedürftigkeit und der gesundheitlichen Versorgung der Pflegebedürftigen in Deutschland. Die Analysen basieren auf GKV-standardisierten AOK-Daten. Sie zeigen Prävalenz, Verläufe und Versorgungsformen der Pflege sowie Kennzahlen zur gesundheitlichen Versorgung der Pflegebedürftigen. Im Fokus stehen die Inanspruchnahme von ärztlichen und stationären Leistungen, Polymedikation und Verordnungen von PRISCUS-Wirkstoffen und Psychopharmaka. Die Ergebnisse werden der Versorgung der Nicht-Pflegebedürftigen gleichen Alters gegenübergestellt und differenziert nach Schwere der Pflegebedürftigkeit und Versorgungssetting ausgewiesen.
The article provides empirical insights on the scope and state of long″​=term care services in Germany. This includes health service provision for persons in need of care. The article lays out key figures regarding the prevalence, pathways and forms of care based on standardised AOK statutory health insurance data. An additional focus lies on the use of outpatient and inpatient health care services as well as on polypharmacy and prescriptions of PRISCUS medication and psychotropic drugs. Findings are contrasted with data on members of the same age group who are not in need of care and discussed in relation to the severity of the need of care and the care provision setting.
Forschung für mehr Qualität in der Versorgung von Pflegebedürftigen: Ein deskriptiver Blick auf die Förderprogramme in SGB V und SGB XI
Authors: Willms Gerald , Behrendt Susann , Argüello Guerra Felipe , Stegbauer Constance 
Published: September 2023

Zusammenfassung
Zusammenfassung
Angesicht der demographischen Entwicklung und der wachsenden Herausforderungen der Sicherstellung einer qualitativ hochwertigen Pflege rückt die Versorgung von dauerhaft pflegebedürftigen Menschen immer mehr auch in das versorgungswissenschaftliche Blickfeld. Begünstigt wird dies durch zahlreiche Förderprogramme für wissenschaftliche Projekte auf Bundesebene bzw. auf Ebene der Selbstverwaltung. Allerdings nimmt mit jeder Förderbekanntmachung nicht nur die Anzahl der Projekte, sondern auch die Komplexität und Vielgestaltigkeit des Projektspektrums zu. Damit steigt das Risiko, dass potenzielle Synergieeffekte der Erkenntnisse auf dem Weg zu einer besseren Versorgung von Pflegebedürftigen verloren gehen bzw. überhaupt nicht erkannt werden.
Ziel des Beitrags ist es, zunächst das Förderspektrum, die pflegerelevanten Versorgungsthemen und das Forschungsinteresse der letzten acht Jahre in deskriptiv-analytischer Perspektive, d. h. auch quantitativ abzubilden. Dabei sollen die Schwerpunktsetzungen der Forschungsförderung und damit auch die Kernelemente der wissenschaftlichen und versorgungspolitischen Auseinandersetzung identifiziert werden, wenn und soweit sie sich mit der Verbesserung der Versorgung von dauerhaft Pflegebedürftigen beschäftigen.
Gesetzliche Qualitätssicherung in der vollstationären Langzeitpflege – historische Entwicklung und Perspektiven
Authors: Schwinger Antje , Behrendt Susann 
Published: September 2023

Zusammenfassung
Zusammenfassung
Die gesetzliche Qualitätssicherung in der vollstationären Langzeitpflege hat sich seit Einführung der Pflegeversicherung erheblich gewandelt. Seit 2019 ist ein neues Qualitätssicherungssystem in Kraft, das externe und interne Qualitätssicherung miteinander verknüpfen soll. Die Ergebnisse der externen Prüfungen durch die Prüfdienste sowie die auf Eigenerhebung der Einrichtungen basierenden Indikatoren zu pflegerischen Versorgungszuständen gehen in die öffentliche Berichterstattung ein. Dies ist grundsätzlich als sinnvolle Weiterentwicklung des Systems zu werten mit dem Ziel, Transparenz für die Verbraucherinnen und Verbraucher zu schaffen und relevantes Wissen in das interne Qualitätsmanagement rückzukoppeln. Die Antwort auf die Frage, wie gut dieses Ziel mit dem neuen System erreicht wird, steht bisher aus. Ermöglicht die neue Qualitätssicherung in der stationären Langzeitpflege eine zuverlässige Bewertung der Einrichtungen? Befähigt sie die Pflegebedürftigen und ihre Angehörigen, wie gesetzlich vorgegeben Pflegeheime auf Basis für sie verständlicher prüf- und indikatorbasierter Kennzahlen für ihre Zwecke zu vergleichen? Evaluation und Weiterentwicklung des Systems sind geboten und die institutionelle Verankerung der Evaluations- und Weiterentwicklungsprozesse ist zu diskutieren.
Ergebnisse und Empfehlungen aus der Pilotierung des neuen Qualitätsprüfungsverfahrens für die ambulante Pflege
Authors: Nolting Hans-Dieter , Haaß Friederike A. , Tisch Thorsten 
Published: September 2023

ZusammenfassungMit der Pflegereform zur Einführung eines neuen Pflegebedürftigkeitsbegriffs (Pflegestärkungsgesetz II) wurde auch die Entwicklung und Einführung neuer Verfahren zur Prüfung und Darstellung der Qualität von Pflegeeinrichtungen beschlossen. Das neue Prüfverfahren für stationäre Pflegeeinrichtungen ist seit Herbst 2019 in Kraft, wogegen die Qualität ambulanter Pflegedienste bislang noch nach den in ihren Verfahrensgrundzügen seit 2016 geltenden Qualitätsprüfungsrichtlinien (QPR) geprüft wird.Ein Grund für das zeitliche Auseinanderfallen der Einführung der neuen Verfahren in beiden Sektoren dürfte in der nur für den ambulanten Bereich gesetzlich vorgesehenen Pflicht zur Pilotierung der neu entwickelten Instrumente und Verfahren bestehen (§ 113b Abs. 4 Nr. 3 SGB XI). Die von den Vertragsparteien mit der Entwicklung der neuen Verfahren beauftragten wissenschaftlichen Einrichtungen haben ihren Abschlussbericht 2018 vorgelegt (Büscher et al. 2018). Im Anschluss daran wurde von Juli 2019 bis Mai 2020 eine umfangreiche Pilotierungsstudie durchgeführt, deren Ergebnisse seit Anfang 2021 auf der Website des Qualitätsausschusses Pflege publiziert sind (Haaß et al. 2021). Der Qualitätsausschuss nimmt eine gründliche Würdigung der Pilotierungsergebnisse sowie ggf. eine Überarbeitung der Verfahren und Instrumente vor, was u. U. die Einführung des neuen Verfahrens verzögert, aber im Sinne der gesetzlich vorgesehenen „Sicherstellung der Wissenschaftlichkeit“ (§ 113b Abs. 4 Satz 1 SGB XI) ist.
Auswirkungen des ordnungspolitischen Rahmens der Pflegeversicherung auf die Qualität der pflegerischen Versorgung
Authors: Greß Stefan , Jesberger Christian 
Published: September 2023

ZusammenfassungDer ordnungspolitische Rahmen der Pflegeversicherung ist seit der Einführung dieses jüngsten Systems der Sozialversicherung im Jahr 1995 trotz einer Vielzahl von Reformen in den Grundzügen vergleichsweise stabil. Daran ändern auch die jüngsten Reformbemühungen des Gesetzgebers im Rahmen des Pflegeunterstützungs- und -entlastungsgesetzes (PUEG) nichts (Sitte et al. 2023). Als Konsequenz wirken die ordnungspolitischen Grundsatzentscheidungen bei der Einführung der Pflegeversicherung bis in die Gegenwart und bestimmen demzufolge bis heute die Reformagenden (Greß und Jesberger 2022). In deren Mittelpunkt steht in den letzten Jahren die Finanzierbarkeit der pflegerischen Versorgung aus Sicht der Kostenträger, der Pflegebedürftigen und der Anbieter. Die Versichertengemeinschaft muss steigende Kosten mit steigenden Beitragssätzen finanzieren. Gleichzeitig nimmt die Belastung der Sozialhilfeträger durch steigende Eigenanteile der Pflegebedürftigen, die selbst zunehmend finanziell überfordert sind, zu. Nach aktuellen Berechnungen werden die Ausgaben für die Hilfe zur Pflege von rund 2,5 Mrd. Euro im Jahr 2022 auf rund 4 Mrd. Euro im Jahr 2026 steigen (Rothgang et al. 2023). Diese weitgehend ungelösten Probleme im Hinblick auf die Finanzierbarkeit pflegerischer Leistungen sind demzufolge für die aktuelle pflegepolitische Debatte hoch relevant – stehen aber nicht im Vordergrund dieses Beitrags.
Minimal codewords in Norm-Trace codes
Authors: Bartoli Daniele , Bonini Matteo , Timpanella Marco 
Published: September 2023

AbstractIn this paper, we consider the affine variety codes obtained evaluating the polynomials $$by=a_kx^k+\ldots +a_1x+a_0$$

b
y
=

a
k

x
k

+
…
+

a
1

x
+

a
0

, $$b,a_i\in {\mathbb {F}}_{q^r}$$

b
,

a
i

∈

F

q
r

, at the affine $${{\mathbb {F}}}_{q^r}$$

F

q
r

-rational points of the Norm-Trace curve. In particular, we investigate the weight distribution and the set of minimal codewords. Our approach, which uses tools of algebraic geometry, is based on the study of the absolute irreducibility of certain algebraic varieties.
Improving the stability of the friction stir channelling technology via a cooled copper backing plate
Authors: Vidal Catarina , Ferreira Pedro M. , Ferreira Francisco B. , Buinho Miguel , Silva Tiago T. , Santos Telmo G. 
Published: September 2023

Abstract
The development of the friction stir channelling (FSC) technology has a potential to revolutionize the manufacturing industry, providing an innovative way to produce continuous sub-surface channels in monolithic components in a single step. However, the process generates heat that can lead to defects and loss of stationarity, affecting the quality of the channels produced and the process’ efficiency and control. To address these challenges, a ground-breaking study was conducted using a cooled copper backing plate to adjust the process temperatures and investigate the influence of the temperature on FSC stability. The results of the study showed that the cooled copper backing plate has a significantly higher rate of heat conduction, effectively preventing the processed component from overheating and ensuring that the process maintains its stationarity. When using the steel backing plate, only one combination of process parameters (a rotation speed of 450 rev/min and a traverse speed of 71 mm/min) yielded satisfactory results. Moreover, the use of the cooled copper backing plate allowed for a wider range of process parameters to be employed, resulting in sub-surface channels with higher quality and fewer defects. The 710/71 parameters combination resulted in a lower heat input, while the 900/45 parameters set produced channels with a more rectangular geometry. A rotation speed of 900 rev/min and a traverse speed of 45 mm/min have been shown to be the best choice. This innovative approach to FSC technology represents a major step forward in solid-state manufacturing, envisaging new possibilities for producing longer sub-surface channels with superior quality and greater efficiency.

Highlights
• Conducting the FSC process at low temperature has improved its stability.
• The use of a cooled copper backing plate enabled a broader range of FSC process parameters.
• Longer and stabler leak-free sub-surface channels have been produced in aluminium alloys.

Graphical Abstract
A phase I/II study of the safety and efficacy of [177Lu]Lu-satoreotide tetraxetan in advanced somatostatin receptor-positive neuroendocrine tumours
Authors: Wild Damian , Grønbæk Henning , Navalkissoor Shaunak , Haug Alexander , Nicolas Guillaume P. , Pais Ben , Ansquer Catherine , Beauregard Jean-Mathieu , McEwan Alexander , Lassmann Michael , Pennestri Daniele , Volteau Magali , Lenzo Nat P. , Hicks Rodney J. 
Published: September 2023

Abstract
Purpose
We present the results of an open-label, phase I/II study evaluating the safety and efficacy of the novel somatostatin receptor (SSTR) antagonist [177Lu]Lu-satoreotide tetraxetan in 40 patients with previously treated, progressive neuroendocrine tumours (NETs), in which dosimetry was used to guide maximum administered activity.

Methods
This study was conducted in two parts. Part A consisted of 15 patients who completed three cycles of [177Lu]Lu-satoreotide tetraxetan at a fixed administered activity and peptide amount per cycle (4.5 GBq/300 µg). Part B, which included 25 patients who received one to five cycles of [177Lu]Lu-satoreotide tetraxetan, evaluated different administered activities (4.5 or 6.0 GBq/cycle) and peptide amounts (300, 700, or 1300 μg/cycle), limited to a cumulative absorbed radiation dose of 23 Gy to the kidneys and 1.5 Gy to the bone marrow.

Results
Median cumulative administered activity of [177Lu]Lu-satoreotide tetraxetan was 13.0 GBq over three cycles (13.1 GBq in part A and 12.9 GBq in part B). Overall, 17 (42.5%) patients experienced grade ≥ 3 treatment‑related adverse events; the most common were lymphopenia, thrombocytopenia, and neutropenia. No grade 3/4 nephrotoxicity was observed. Two patients developed myeloid neoplasms considered treatment related by the investigator. Disease control rate for part A and part B was 94.7% (95% confidence interval [CI]: 82.3–99.4), and overall response rate was 21.1% (95% CI: 9.6–37.3).

Conclusion
[177Lu]Lu-satoreotide tetraxetan, administered at a median cumulative activity of 13.0 GBq over three cycles, has an acceptable safety profile with a promising clinical response in patients with progressive, SSTR-positive NETs. A 5-year long-term follow-up study is ongoing.

Trial registration
ClinicalTrials.gov, NCT02592707. Registered October 30, 2015.
Safety and Effectiveness of a Novel Tips Access Set with Steerable Cannula in a Swine Model
Authors: Ding PengXu , Ma Yujia , Zhu Xiaoxia , Wu Yijie , Ong John , Liu Pu , Xiao Jiangqiang , Zhuge Yuzheng 
Published: September 2023

Abstract
Purpose
This study aimed to assess the safety, effectiveness, and feasibility of the Liverty™ transjugular intrahepatic portosystemic shunt (TIPS) access set, which has an ergonomic handle that allows for in situ cannula tip deflection and a distal steerable cannula angle, versus the COOK® Rosch-Uchida Transjugular Liver Access Set (RUPS-100) in healthy pigs.

Methods
Twelve pigs randomly underwent TIPS with the Liverty™ set or the RUPS-100 set. Three interventionalists performed 4 TIPS procedures, 2 with each set. The primary outcome was procedural success, defined as successful establishment of the intrahepatic portosystemic shunt and stent placement.

Results
The shunt was successfully established in 11 pigs. The procedural success was achieved in all 6 pigs in the Liverty™ group and 5 out of 6 pigs for the RUPS-100 group (Fisher exact test, P > 0.999). The mean duration of puncture was shorter in the Liverty™ group versus the RUPS-100 group (12.3 ± 4.5 min vs. 16.2 ± 8.5 min), but without significant statistical difference (two sample t test, P = 0.359). The cannula angle was adjusted 69% of passes in the Liverty™ group, which was significantly higher than that in the RUPS-100 group (12%, P = 0.004). Overall, the TIPS procedural performance was comparable between the groups. Both sets were safe. No intraabdominal hemorrhage, vascular injuries, tissue or organ injuries, porto-biliary fistula, biliary peritonitis, and infection or abscess occurred in either group.

Conclusion
The Liverty™ set is safe and has similar procedural metrics to the COOK® RUPS-100 set. It allows in situ adjustment of the angle of the stiffening cannula without increasing procedure time and lessens the occurrences of periprocedural complications.

Graphical Abstract