bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Knowledge and Compliance with Pitch Count Recommendations Among Youth Baseball Coaches Over a Decade and Its Actual Conditions of Coaching
Authors: Onishi Miyu , Kouno Chika , Kawabe Rika , Doi Naoki , Tahu Yukinobu , Nagai-Tanima Momoko , Aoyama Tomoki 
Published: March 2023

Abstract

Background: In Japan, pitch count recommendations were proposed to prevent throwing injuries. In our laboratory, 10 years ago, the knowledge and compliance with pitch count recommendations were assessed among coaches in Kyoto Prefecture and compared with those in the U.S. The environment surrounding youth baseball has changed over time, but there are no studies that survey changes in knowledge and compliance with pitch count recommendations among coaches, as a result of changes in the baseball environment. Although it is important for coaches to have prior knowledge of injuries in order to prevent the incidence of baseball elbow, few studies have assessed the actual experience of coaches.Methods: We conducted a paper-based survey among coaches of youth baseball teams in Kyoto Prefecture. The survey included the questions about basic information, knowledge about baseball elbow, compliance with the recommendations, and participation in seminars and workshops.Results: A total of 242 participants (84 teams) participated in this study, and data of 172 coaches were analyzed. Approximately 52.3% coaches had knowledge on pitch count recommendations, an increase from 39.8% conducted in our laboratory 10 years ago, but the compliance rate has not changed. There was a significant difference between the presence of knowledge about baseball elbow and participation in seminars and workshops regarding coaching experience.Conclusion: Knowledge retention rate increased compared to 10 years ago, but compliance rates did not change. Additionally, characteristics of the coaches were revealed regarding their coaching experience.
Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice
Authors: Zuo Yuanbojiao , Zhang Chen , Zhou Yuan , Li Haiwen , Xiao Weidong , Herzog Roland W. , Xu Jie , Zhang Jifeng , Chen Eugene Y. , Han Renzhi 
Published: March 2023

Abstract
Background:
Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene editing offers hope for a permanent solution to lower cardiovascular disease risks associated with hypercholesterolemia.
Results:
In this study, we developed a liver-specific base editing therapeutic approach delivered by dual adeno-associated virus (AAV) to enable liver-specific targeting of Angptl3 to lower blood lipid levels. Systemic AAV9-mediated delivery of AncBE4max, a cytosine base editor (CBE), targeting mouse Angptl3 resulted in the installation of a premature stop codon in Angptl3 with an average efficiency of 63.3 ± 2.3% in the bulk liver tissue. A near-complete knockout of the ANGPTL3 protein in the circulation were observed within 2-4 weeks following AAV administration. Furthermore, the serum levels of triglyceride (TG) and total cholesterol (TC) were decreased by approximately 58% and 61%, respectively, at 4 weeks after treatment.
Conclusions:
These results highlight the promise of liver-targeted Angptl3 base editing for blood lipid control.
Relationships between self-perceived and clinical expression of pain and function differ based on the underlying pathology of the human hip
Authors: Nunley Brandon , Mulligan Edward , Chhabra Avneesh , Fey Nicholas , Wells Joel 
Published: March 2023

Abstract
Background
Patient-reported outcomes are commonly used to assess patient symptoms and track post-operative improvements. The effect that specific hip pathology has on the relationship between perceived and objectively measured symptoms remains unclear. The purpose of this study was (1) to evaluate differences of function and pain in FAIS and DDH patients, (2) to assess the correlation between perceived and true functional ability, and (3) to determine the influence of pain on measures of function.
Methods
This prospective cross-sectional study included 73 pre-operative patients with femoroacetabular impingement syndrome (FAIS) and developmental dysplasia of the hip (DDH), who were diagnosed based on clinical history, physical examination, and radiographic findings. Objectively measured function (6-minute walk test [6MWT], single leg hop test [SLHT], Biodex sway test [BST], hip abduction strength test [HABST], and STAR excursion balance reach tests [STAR] in multiple directions), patient-reported function (UCLA Activity scale, Hip Outcome Score [HOS] activities of daily living [ADL] and Sport subscales, Short Form 12 [SF-12] Physical Activity subscale, and the Hip Disability and Osteoarthritis Outcome Score [HOOS] ADL and Sport), and patient-reported pain data (HOOS Pain, visual analogue scale (VAS), and a pain location scale with eight bilateral body locations) were collected during pre-surgical clinic visits. Patient demographics were compared using independent two-sample t-tests. Between-group comparisons of patient scores were performed using Wilcoxon Rank-Sum tests. Within-group relationships between pairs of outcome variable were analyzed using Spearman’s rank correlation coefficients. The level of significance for all statistical tests was set at α = 0.05 (two-tailed).
Results
6MWT was moderately-to-strongly correlated with nearly all patient-reported measures of function (FAIS: r = 0.34–0.62, DDH: r = 0.27–0.56). In FAIS patients, only HOOS Pain was significantly correlated with an objective measure of function, which was 6MWT (r=-0.53). However, in DDH patients, patient-reported pain scores were moderately correlated with a number of objective measures of function (r=-0.32–0.48).
Conclusion
FAIS patients reported significantly higher function and lower pain compared to DDH patients. No single patient-reported measure of function was broadly significantly correlated with objective measures of function in either patient group. Functional performance in patients with DDH appears to be influenced by self-perceived pain.
Characterization of fine particles in urban areas of Shanghai
Authors: Wang Hongqiang , Gao Xing , Chen Mingtao , Huang Jun , Zuo Yanqiu 
Published: March 2023

Abstract
Based on five consecutive years of measured data from January 2008 to December 2012 at representative observation sites in Shanghai, we analyzed the fine particle mass concentrations and their variation characteristics. The main conclusions drawn are as follows: the annual average mass concentrations of PM (including PM1, PM2.5 and PM10) in Shanghai city exhibited a decreasing trend. PM1 decreased from 46.7 ± 34.7 to 32.1 ± 25.4 µg/m3 (annual mean ± standard deviation), PM2.5 decreased from 53.2 ± 37.4 to 36.7 ± 26.9 µg/m3 and PM10 decreased from 70.2 ± 46.7 to 49.2 ± 34.7 µg/m3. In terms of the 5-year average mass concentrations, PM1, PM1–2.5 (particulate matter with a particle size dp of 1–2.5 µm) and PM2.5–10 (particulate matter with a dp of 2.5–10 µm) accounted for about 61.1%, 11.3% and 27.6% of PM10, respectively. The seasonal average mass concentrations of PM1, PM2.5 and PM10 from 2008 to 2012 were highest in winter, followed by autumn and lowest in summer. The average mass concentration of PM1–10 (particulate matter with a dp of 1–10 µm) was 2.2, 1.7 and 1.4 times higher in spring than in summer, autumn and winter, respectively. The proportion of PM1–10 to PM10 was 48.9%, 37.0%, 35.9% and 33.3% in spring, summer, autumn and winter. In spring, Shanghai was affected by sand and dust aerosols from northern China and more severely by PM1–10 from Zhejiang, Jiangxi and Fujian; in autumn and winter, Shanghai was more influenced by PM1–10 from Henan, Hubei and Anhui.
C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel
Authors: Shirakawa Tsuyoshi , Akitaka Makiyama , Shimokawa Mototsugu , Otsuka Taiga , Shinohara Yudai , Koga Futa , Ueda Yujiro , Nakazawa Junichi , Otsu Satoshi , Komori Azusa , Arima Shiho , Fukahori Masaru , Taguchi Hiroki , Honda Takuya , Shibuki Taro , Nio Kenta , Ide Yasushi , Ureshino Norio , Mizuta Toshihiko , Mitsugi Kenji , Akashi Koichi , Baba Eishi 
Published: March 2023

Abstract
There are limited absolute biomarkers for determining the prognosis before first- and second-line palliative chemotherapy in unresectable pancreatic cancer (urPC) patients. To find the best prognostic inflammatory marker, we investigated relationships between overall survival (OS) and six inflammatory markers; C-reactive protein/albumin ratio (CAR), neutrophil–lymphocyte ratio (NLR), prognostic nutrition index (PNI), platelet–lymphocyte ratio (PLR), Glasgow prognostic score (GPS), and prognostic index (PI). We examined 255 patients who received gemcitabine + nab-paclitaxel or FOLFIRINOX as first-line chemotherapy and 159 patients who subsequently underwent second-line chemotherapy. First-line patients with lower CAR had better OS compared to those with a higher CAR (hazard ratio 0.57; 95% confidential index 0.42–77; P < 0.01). Similarly, lower NLR (P = 0.01), higher PNI (P = 0.04), lower PLR (P = 0.03), GPS score of 0 (P < 0.01) and PI score of 0 (P < 0.01) were all associated with better OS. CAR demonstrated the best superiority for determining survival prognosis through the use of AUC of time-dependent ROC curves. Furthermore, a lower CAR before second-line therapy exhibited better OS versus higher CAR (P < 0.01). Therefore, CAR might be a useful biomarker for predicting urPC patient prognosis in both first- and second-line chemotherapy.
A case of subclinical immune checkpoint inhibitor‐associated myocarditis in non-small cell lung cancer
Authors: Hu Yue , Liu Cuixia , Jin Shaojun , Yi Zihan , Wang Chao , Pan Xiaohong , Huang Huaqiong 
Published: March 2023

Abstract
Background: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of cancer. Meanwhile, immune-related adverse events (irAEs) have become a new clinical challenge. ICI-associated myocarditis is a rare but fatal condition among diverse organ injuries, and early recognition and effective interventions are critical for patients.
Case presentation: In this report, we present the case of a healthy 60-year-old male who was diagnosed with lung squamous cell carcinomas following chemotherapy and received ICIs. The patient presented with asymptomatic cardiac biomarker elevation followed by immune-related myocarditis. Fortunately, the patient achieved a good clinical result after receiving high-dose steroids. The treatment with ICIs was discontinued because of recurrent increases in troponin T.
Conclusion: ICI-mediated associated myocarditis is an uncommon but potentially life-threatening adverse event. The current data suggest that clinicians need to be cautious about reinitiation in low-grade patients; however, further study of the diagnosis and treatment is necessary.
Knowledge, Attitude, and Readiness of Pharmacists in Iraq toward Medication Therapy Management for Patients with Attention Deficit Hyperactivity Disorder: A Cross-sectional Study
Authors: Al-Dujaili Zahraa , Hallit Souheil , Faraj Achraf Al 
Published: March 2023

Abstract
Background
Medication Therapy Management (MTM) is a patient-centered, collaborative service that optimizes drug therapy and improves clinical outcomes, including quality of life. Pharmacists play a critical role in MTM service and are uniquely positioned to provide comprehensive medication management for patients with attention deficit hyperactivity disorder (ADHD).
Aim
The aim of this study was to assess the knowledge, attitude, and readiness of Iraqi pharmacists regarding MTM service in general and medication management of ADHD patients.
Method
A cross-sectional study was conducted among 480 Iraqi pharmacists working in community pharmacies in Baghdad. Data were collected using a pre-validated 34-item self-administered questionnaire.
Results
Results showed that only 26.5% of pharmacists had good knowledge, 30.4% had good attitude, and 30.8% had high readiness regarding MTM service and ADHD medication management. Multivariate analyses revealed that a higher number of hours worked per week in the hospital was significantly associated with a lower likelihood of a high attitude, whereas experience with MTM, high knowledge, and high attitude were significantly associated with a higher likelihood of high readiness.
Conclusion
The findings of this study indicate that knowledge, attitudes, and readiness regarding MTM service and ADHD medication management are inadequate. Therefore, there is an urgent need for effective educational strategies to better prepare pharmacists for their potential role in the community, particularly for the provision of MTM service and ADHD care. In this way, pharmacists can better assist patients in managing their medications, improve clinical outcomes and ultimately increase the efficiency of the overall health care system.
Association between location of prenatal care services and non-consented cesarean sections in Mexico: a secondary analysis of the National Survey on the Dynamics of Household Relationships 2016
Authors: Marian Marian , Pérez Ramona 
Published: March 2023

Abstract
Background
Mexico has one of the world’s highest rates of cesarean section (C-section), which is part of the growing problem with obstetric violence the country faces. Little is known about Mexico’s frequency of and risk factors for non-consented C-sections, a form of obstetric violence. We examined the association between the location of prenatal care services and receiving a non-consented C-section.
Methods
We used the 2016 Mexico National Survey on the Dynamics of Household Relationships (ENDIREH 2016) to conduct secondary data analysis with a sample of 10,306 women who reported a C-section during their latest pregnancy. We conducted multivariable logistic regression to examine the relationship between location of prenatal care service and receiving a non-consented cesarean delivery between 2011 and 2016 among Mexican women of reproductive age.
Results
Of all women, 9.8% of respondents who had C-sections were not informed that it was necessary, while 9.2% did not give permission for this procedure. The odds of having a non-consented cesarean were higher for women who received prenatal services in private settings, an IMSS facility, an ISSSTE facility, or more than one type of facility, compared to a public community health center. Among participants who reported Indigenous belonging, receiving prenatal services at a private or ISSSTE facility was also associated with non-consented cesarean delivery. Additionally, when comparing all public prenatal care locations with private, we found that receiving prenatal care at a private facility or at both public and private settings, were associated with increased odds of non-consented cesarean delivery. Similar results were observed for participants not of Indigenous belonging, while only private setting was associated with increased odds of non-consented C-sections for respondents of Indigenous belonging.
Conclusions
This analysis indicates that receiving prenatal care at an ISSSTE, IMSS, private facility, or a combination of public and private services increases the risk of non-consented C-section in Mexico. These findings recommend the need to implement actions to improve the functioning of prenatal and delivery care in the different health systems to prevent mistreatment during C-section procedures. Additional research is required to further understand the factors associated with non-consented C-sections in Mexico.
A novel concentrated growth factor (CGF)-based strategy for second molar protection after impacted mandibular third molar extraction: a randomized controlled clinical study
Authors: Sun Shoufu F. , Xu Xiaodong D. , Zhang Zhongxiao X. , Zhang Ying , Wei Wenjia J. , Jiang Yunan N. , Guo K. 
Published: March 2023

Abstract
Background：The extraction of impacted mandibular third molars might cause large bone defects in the distal area of second molars. A new strategy was innovatively employed here combining autologous bone, Bio-Oss, concentrated growth factors (CGF) gel and CGF membrane for bone repair, and the present study aimed at exploring safety as well as short- and long-term efficacy of this new protocol clinically.
Materials and methods: A total of 66 participants were enrolled in this randomized single-blind clinical trial, and randomly allocated to control group (only blood clots), test A group (autogenous bone，Bio-Oss with oral repair membrane) and test B group (autogenous bone，Bio-Oss, CGF gel with CGF membrane). The postoperative outcomes including PoSSe scale, periodontal probing depth (PD), degree of gingival recession and computed tomography measurements were assessed at 3th, 6th, 12th month. A p-value<0.05 was considered statistically significant.
Results: In PoSSe scale, no significant difference was observed except a significant alleviation of early-stage pain perception in test B group (p<0.05). Also, test B group exhibited better effect on periodontal healing and gingival recession reduction after 6 months (p<0.05). Both two test groups showed more new bone formation than the control group (p<0.05). It is noteworthy that the bone repair of test B group was significantly better than that of test A at 3th and 6th month (p<0.05), yet no difference was observed at 12th month (p>0.05).
Conclusion: Both two test groups could achieve stable long-term efficacy on alveolar bone repair. The use of CGF gel and CGF membrane could accelerate early-stage bone repair, alleviate short-term pain after surgery, reduce long-term probing depth and relieve economic cost for patients. This new bone repair protocol is worthy of promoting by clinicians.
Trial registration: This study was registered with the identification number ChiCTR2300068466 on 20/02/2023 at Chinese Clinical Trial Registry. Also, it was ethically approved from the institutional ethics committee at the Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (No:2023-010-01), and has been conducted in accordance to the guidelines of the declaration of Helsinki. Written informed consent was obtained from all participants in the study.
Machining Grade 4 Titanium alloy by Minimum Quantity Lubrication (MQL) for enhanced environmentally sustainable manufacturing.
Authors: Mathonsi Thabo Nelson , Laubscher Rudolph Frans 
Published: March 2023

Abstract
Machining is a widely used class of industrial manufacturing operation, wherein cutting fluids play a vital role in terms of machining accurate dimensional quality objects due to their cooling, lubricant and chip removal abilities. Although certain advanced cutting fluids have changed the manufacturing industry for the better, there are some environmental concerns associated with some of these fluids. The use and disposal of cutting fluids may be costly and subjected to stringent government laws. Hence, the ever-growing research conducted on environmentally friendly cutting fluids that may lead to enhanced sustainable manufacturing. The aim of this investigation is therefore to investigate the viability of Minimum Quantity Lubrication (MQL) during machining of titanium alloys with specific focus on the commercially pure grades (Grade 4). A comparative study was conducted in order to establishing the effects of different modes of lubrication i.e. Dry, wet and MQL machining on titanium.
Ce-Mediated Molecular Tailoring on an Unprecedented Gigantic Polyoxometalate {Mo132} into Half-Closed Product {Ce11Mo96} for Achieving High Proton Conduction
Authors: Li Xue-Xin , Li Cai-Hong , Hou Ming-Jun , Chen Wei-Chao , Sun Chun-Yi , Yuan Ye , Qin Chao , Shao Kui-Zhan , Wang Xinlong , Su Zhong-Min 
Published: March 2023

AbstractPrecise synthesis of polyoxometalates (POMs) is important for the fundamental understanding of the relationship between the structure and function of each building motif. However, it is a great challenge to realize the atomic-level tailoring of specific sites in POMs without altering the major framework. Herein, we report the first case of Ce-mediated molecular tailoring on the unprecedented gigantic {Mo132}, which has a closed structural motif involving a never seen {Mo110} decamer. Such capped wheel {Mo132} undergoes a rare quasi-isomerism with known {Mo132} ball displaying different optical behaviors. Experiencing an ‘Inner-On-Outer’ binding process with the substituent of {Mo2} reactive sites in {Mo132}, the site-specific Ce ions drive the dissociation of {Mo2*} clipping sites and finally give rise to a predictable half-closed product {Ce11Mo96}. By virtue of the tailor-made open cavity, the {Ce11Mo96} achieves high proton conduction, nearly two orders of magnitude than that of {Mo132}. This work offers a significant step toward the controllable assembly of POM clusters through a Ce-mediated molecular tailoring process for desirable properties.
F-RUS-RF: A Hybrid Machine Learning Approach for Cancer Detection in Older Adults
Authors: Javeed Ashir , Dallora Ana Luiza , Saleem Muhammad Asim , Ali Liaqat , Berglund Johan Sanmartin , Anderberg Peter 
Published: March 2023

Abstract
Background: Globally, cancer is the second-leading cause of mortality, behind cardiovascular diseases. Although cancer affects people of all ages, most cases occur among those in their fifth or sixth decade of life; hence, the chance of developing cancer grows significantly with age. Early cancer prediction and its risk factors are crucial since it increases survival rates. Motivated by this fact, we conducted this study on a Swedish older adult sample, where the proposed model based on machine learning (ML) not only predicted cancer but also identified risk factors for cancer in older adults.
Results: The newly proposed model comprises two modules. The first module uses an F-score statistical model to rank the variables from the acquired dataset, which consists of 75 variables, and the second module serves as a classifier. For the classification job, we deployed the random forest (RF) algorithm, and the hyperparameters of the RF model were optimized by employing a genetic algorithm. The highly significant variables determined in the first module are fed into the second module for cancer prediction. It was observed during the study that classes in the dataset were highly imbalanced. To avoid the problem of bias in the ML model, we deployed a random undersampling approach to balance the classes in the dataset. The components of the proposed model are combined into a single unit that functions as a ”black box.” The newly constructed model for cancer prediction was named F-RUS-RF. The highest accuracy achieved by the F-RUS-RF model for cancer prediction while using only the top six ranked variables was 86.15%, with sensitivity and specificity of 92.25% and 85.14%, respectively.
Conclusions: The proposed F-RUS-RF model helped us predict cancer and identified the risk factors of cancer in older adults. From the total of 75 variables in the dataset, the six most significant variables were determined by the proposed F-RUS-RF model, which actually causes cancer in older adults. By taking care of these risk factors, we can reduce the risk of cancer in older adults.