bluuebunny/crossref_metadata_2025_split huggingface dataset:
The timing of the deglaciation in the Atlantic Iberian mountains: Insights from the stratigraphic analysis of a lake sequence in Serra da Estrela (Portugal)
Authors: Hernández Armand , Sáez Alberto , Santos Ricardo N. , Rodrigues Teresa , Martin‐Puertas Celia , Gil‐Romera Graciela , Abbott Mark , Carballeira Rafael , Costa Pedro , Giralt Santiago , Gomes Sandra D. , Griffore Melissa , Ibañez‐Insa Jordi , Leira Manel , Moreno João , Naughton Filipa , Oliveira Dulce , Raposeiro Pedro M. , Trigo Ricardo M. , Vieira Gonçalo , Ramos Alexandre M. 
Published: December 2022

AbstractUnderstanding the environmental response to the last glacial termination in regions located in transitional climate zones such as the Atlantic Iberian mountains is crucial to estimate potential changes in regions affected by current glacial melting. We present an 8.5 m‐long, solid last deglaciation and Holocene chronostratigraphic record including detailed sediment analysis from Lake Peixão, a pro‐glacial lake in the Serra da Estrela (Central Portugal). The age–depth model relies on a Bayesian approach that includes 16 AMS 14C dates and 210Pb–137CS measurements, robustly dating the lake formation at 14.7 ± 0.32 cal. ka BP. This chronological reconstruction shows an average sedimentation rate of ca. 0.07 cm yr−1 (15 yr cm−1), enabling proxy analyses at decadal timescales. The sediment sequence is composed of five lithological units: (U1) coarse and unsorted fluvioglacial lacustrine deposits; (U2) massive fluvioglacial lacustrine deposits (863–790 cm below surface [bsf]; 14.7 ± 0.32–13.8 ± 0.12 cal. ka BP); (U3) water current fluvioglacial lacustrine deposits (790–766 cm bsf; 13.8 ± 0.12–12.9 ± 0.29 cal. ka BP); (U4) laminated/banded lacustrine deposits characterized by terrigenous deposits from ice‐covered lake periods and episodic events of ice and snow melting (766–752 cm bsf; 12.9 ± 0.29–11.7 ± 0.15 cal. ka BP); and (U5) massive muddy lacustrine deposits (752–0 cm bsf; 11.7 ± 0.15 cal. ka BP–present). The occurrence of U2 to U4 deposits defines the transition from glacial cold (U1) to net warm postglacial conditions (U5). These climate transitions are marked by changes in sediments and the presence of very low sedimentation rate periods, possibly related to the Intra‐Allerød Cold Period and the coldest phase of the Younger Dryas. Our results support the previously proposed timing of the retreat of the Serra da Estrela glaciers ca. 13.8 ± 0.12 cal. ka BP. The robust chronology of Lake Peixão highlights the potential of Iberian pro‐glacial lakes for dating deglaciation processes and will lead to unprecedented decadal‐to‐centennial timescale palaeoclimate reconstructions in this region since the last glacial–interglacial transition.
The impact of a meta‐analysis on orthopaedic surgeons' practice with regards to vancomycin graft pre‐soaking in anterior cruciate ligament reconstruction: A paper questionnaire survey study
Authors: Kuršumović Kenan , Charalambous Charalambos Panayiotou 
Published: December 2022

AbstractBackground and AimsUnderstanding the impact of orthopaedic scientific research is vital in identifying facilitators and barriers to its implementation in clinical practice. A meta‐analysis was carried out which showed that presoaking hamstring (HT) autografts in vancomycin was associated with a 10‐fold reduction in infection rate in anterior cruciate ligament (ACL) reconstruction. Our aim was to determine the practice of orthopaedic surgeons with regards to vancomycin presoaking and explore whether they would adopt the findings of this meta‐analysis.MethodsA paper questionnaire survey was administered to attendees of an annual EFORT podium presentation of the meta‐analysis findings. Descriptive statistics were used to summarize the characteristics of respondents and their responses.ResultsA total of 29 senior surgeons/subspecialists performing a median of 40 ACL reconstructions per year completed the survey of whom 7 (24.1%) had encountered an ACL graft infection in the previous 2 years and 14 (48.3%) in the previous 5 years. Only 3 (10.3%) presoaked the ACL graft with an antibiotic. About 1/4 of those who up to then did not pre‐soak the graft (6/26, 23.1%) would consider changing their practice to pre‐soaking with vancomycin, with similar findings (5/20, 25.0%) in those that used a HT autograft as their first choice.ConclusionsOrthopaedic surgeons are receptive to the findings of a meta‐analysis reporting on the effectiveness of vancomycin graft presoaking in ACL reconstruction, which can thus have a substantial impact upon clinical care. Addressing concerns about vancomycin induced graft toxicity and comparing the pre‐soaking effect to that of specific intravenous antibiotic regimens may further enhance the uptake of this practice.
Long‐term survival trends in solid cancers in the Nordic countries marking timing of improvements
Authors: Hemminki Kari , Försti Asta , Liska Vaclav , Kanerva Anna , Hemminki Otto , Hemminki Akseli 
Published: December 2022

AbstractSurvival studies are an important indicator of the success of cancer control. We analyzed the 5‐year relative survival in 23 solid cancers in Denmark, Finland, Norway and Sweden over a 50‐year period (1970‐2019) at the NORDCAN database accessed from the International Agency for Research on Cancer website. We plotted survival curves in 5‐year periods and showed 5‐year periodic survival. The survival results were summarized in four groups: (1) cancers with historically good survival (>50% in 1970‐1974) which include melanoma and breast, endometrial and thyroid cancers; (2) cancers which constantly improved survival at least 20% units over the 50 year period, including cancers of the stomach, colon, rectum, kidney, brain and ovary; (3) cancer with increase in survival >20% units with changes taking place in a narrow time window, including oral, oropharyngeal, testicular and prostate cancers; (4) the remaining cancers with <20% unit improvement in survival including lung, esophageal, liver, pancreatic, bladder, soft tissue, penile, cervical and vulvar cancers. For cancers in groups 1 and 2, the constant development implied multiple improvements in therapy, diagnosis and patient care. Cancers in group 3 included testicular cancers with known therapeutic improvements but for the others large incidence changes probably implied that cancer stage (prostate) or etiology (oropharynx) changed into a more tractable form. Group 4 cancers included those with dismal survival 50 years ago but a clear tendency upwards. In 17 cancers 5‐year survival reached between 50% and 100% while in only six cancers it remained at below 50%.
Increased nuchal translucency with normal karyotype and genomic microarray analysis: A multicenter observational study
Authors: Spataro Elisa , Cordisco Adalgisa , Luchi Carlo , Filardi Gilda Rosaria , Masini Giulia , Pasquini Lucia 
Published: December 2022

AbstractObjectiveTo define the residual risk of morbidity‐related outcome in fetuses with nuchal translucency (NT) of 3.5 mm or more after normal genetic testing and mid‐trimester anomaly scan.MethodsA total of 114 fetuses with isolated NT of 3.5 mm or more, normal karyotype, and array‐based comparative genomic hybridization (array‐CGH) were included and divided in three groups: NT 3.5–4.5 mm, NT 4.5–6 mm, and NT greater than 6 mm. RASopathy testing and ultrasound follow up were performed in all fetuses. We evaluated: (1) incidence of genetic disorders; (2) incidence of structural abnormalities; (3) pregnancy outcome; (4) long‐term pediatric outcome before (point 1) and after (point 2) a normal RASopathy testing and mid‐trimester anomaly scan.ResultsAfter normal karyotype and array‐CGH the residual risk of morbidity‐related outcome was 24.64% for NT 3.5–4.5 mm, 25% for NT 4.5–6 mm and 76.47% for NT more than 6 mm. After a normal RASopathy testing and mid‐trimester anomaly scan the residual risks decreased to 7.14%, 8.69%, and 33.3% in the three groups, respectively.ConclusionIn fetuses with an NT of 3.5 mm or more and both normal karyotype and array‐CGH, the rate of morbidity‐related outcome depends on NT size. A normal RASopathy testing and mid‐trimester ultrasound are reassuring but the residual risk of morbidity‐related outcome is increased compared with the general population, particularly if NT is greater than 6 mm.
Endometrial Cancer Individualized Scoring System (ECISS): A machine learning‐based prediction model of endometrial cancer prognosis
Authors: Shazly Sherif A. , Coronado Pluvio J. , Yılmaz Ercan , Melekoglu Rauf , Sahin Hanifi , Giannella Luca , Ciavattini Andrea , Carpini Giovanni Delli , Di Giuseppe Jacopo , Yordanov Angel , Karakadieva Konstantina , Nedelcheva Nevena Milenova , Vasileva‐Slaveva Mariela , Alcazar Juan Luis , Chacon Enrique , Manzour Nabil , Vara Julio , Karaman Erbil , Karaaslan Onur , Hacıoğlu Latif , Korkmaz Duygu , Onal Cem , Knez Jure , Ferrari Federico , Hosni Esraa M. , Mahmoud Mohamed E. , Elassall Gena M. , Abdo Mohamed S. , Mohamed Yasmin I. , Abdelbadie Amr S. ,   Middle‐Eastern College of Obstetricians and Gynaecologists (MCOG) Muti‐Center Studies (MCS) office and Artificial Intelligence Unit (AI)
Published: December 2022

AbstractObjectiveTo establish a prognostic model for endometrial cancer (EC) that individualizes a risk and management plan per patient and disease characteristics.MethodsA multicenter retrospective study conducted in nine European gynecologic cancer centers. Women with confirmed EC between January 2008 to December 2015 were included. Demographics, disease characteristics, management, and follow‐up information were collected. Cancer‐specific survival (CSS) and disease‐free survival (DFS) at 3 and 5 years comprise the primary outcomes of the study. Machine learning algorithms were applied to patient and disease characteristics. Model I: pretreatment model. Calculated probability was added to management variables (model II: treatment model), and the second calculated probability was added to perioperative and postoperative variables (model III).ResultsOf 1150 women, 1144 were eligible for 3‐year survival analysis and 860 for 5‐year survival analysis. Model I, II, and III accuracies of prediction of 5‐year CSS were 84.88%/85.47% (in train and test sets), 85.47%/84.88%, and 87.35%/86.05%, respectively. Model I predicted 3‐year CSS at an accuracy of 91.34%/87.02%. Accuracies of models I, II, and III in predicting 5‐year DFS were 74.63%/76.72%, 77.03%/76.72%, and 80.61%/77.78%, respectively.ConclusionThe Endometrial Cancer Individualized Scoring System (ECISS) is a novel machine learning tool assessing patient‐specific survival probability with high accuracy.
The incidence of post‐traumatic stress disorder following traumatic childbirth: A systematic review and meta‐analysis
Authors: Lai Xiaolu , Chen Jingfen , Li Haiqi , Zhou Lepeng , Huang Qianyi , Liao Yan , Krewski Daniel , Wen Shi Wu , Zhang Lili , Xie Ri‐Hua 
Published: December 2022

AbstractBackgroundAlthough birth trauma may be a risk factor for postpartum post‐traumatic stress disorder (PTSD), no systematic review regarding the incidence of postpartum PTSD in women with traumatic childbirth has been reported.ObjectiveTo estimate the incidence of PTSD in women following traumatic childbirth by systematically reviewing and synthesizing all available evidence.Search StrategySix databases were searched using a combination of related terms for birth trauma and PTSD.Selection CriteriaCohort and cross‐sectional studies that were related to traumatic childbirth and PTSD were included.Data Collection and AnalysisTwo reviewers independently screened potentially relevant studies and extracted key data elements. A series of meta‐analyses were conducted using STATA 17.0 software, with pooled incidence rates estimated using random effects models.Main ResultsA total of nine studies were included in this study. The pooled incidence of PTSD after traumatic childbirth was 19.4% (95% confidence interval 11.9%–26.5%). The incidence of PTSD varied with the scales used to assess traumatic birth and PTSD, evaluation times of PTSD after childbirth, and types of study participants.ConclusionsThe incidence of PTSD in women with traumatic childbirth is about 19%, higher than the general obstetric population, suggesting that trauma‐related care for them should be enhanced.
Benefits of physical therapy in improving quality of life and pain associated with endometriosis: A systematic review and meta‐analysis
Authors: Abril‐Coello Rebeca , Correyero‐León Marta , Ceballos‐Laita Luis , Jiménez‐Barrio Sandra 
Published: December 2022

AbstractObjectiveTo assess whether non‐pharmacologic conservative therapeutic interventions are beneficial in improving pain intensity and quality of life in women with endometriosis compared with placebo.MethodsA systematic review with meta‐analysis was designed. A literature search was performed in the following databases: PubMed, PEDro, Embase, CINAHL, Isi Web of Science, Enfispo, and Cochrane. Randomized controlled trials included women with endometriosis treated with conservative treatment versus placebo. The quality of the studies was assessed using the PEDro scale, and the risk of bias of the individual studies was assessed using the Cochrane Risk of Bias tool. For the overall quality of the studies, the GRADE guidelines were used.ResultsMeta‐analysis included six studies. Significant results were obtained for pain intensity (standardized mean difference [SMD] –0.89; 95% confidence interval [CI] –1.21 to −0.57; I2 69%) and concerning quality of life, significant results were only obtained for the sub‐variable physical function (SMD –1.49; 95% CI –2.88 to −0.10; I2 95%). No statistically significant differences were found for the rest of the variables analyzed.ConclusionNon‐pharmacologic conservative therapies are a therapeutic option for women with endometriosis for improving pain intensity and physical function.
Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties
Authors: Radisavljevic Andjela , Stojanovic Dusica B. , Petrovic Milos , Radojevic Vesna , Uskokovic Petar , Rajilic‐Stojanovic Mirjana 
Published: December 2022

AbstractIn this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract‐ Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an increase in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow‐loaded PCL nanofiber mats appeared to be multi‐functional biomaterials suitable for the production of catheter‐coating materials, patches, or gauzes with antibacterial and antioxidant properties.
Triceps skinfold–albumin index significantly predicts the prognosis of cancer cachexia: A multicentre cohort study
Authors: Yin Liangyu , Cui Jiuwei , Lin Xin , Li Long , Li Na , Fan Yang , Zhang Ling , Liu Jie , Chong Feifei , Lu Zongliang , Wang Chang , Liang Tingting , Liu Xiangliang , Deng Li , Yang Mei , Yu Jiami , Wang Xiaojie , Cong Minghua , Li Zengning , Weng Min , Yao Qinghua , Jia Pingping , Guo Zengqing , Li Wei , Song Chunhua , Shi Hanping , Xu Hongxia 
Published: December 2022

AbstractBackgroundThe fat mass and nutritional status play important roles in the onset and progression of cancer cachexia. The present study evaluated the joint prognostic value of the fat mass, as indicated by the triceps skinfold thickness (TSF), and the serum albumin level, for mortality in patients with cancer cachexia.MethodsWe performed a multicentre cohort study including 5134 patients with cancer cachexia from January 2013 to April 2019. The sum of the TSF (mm) and serum albumin (g/L) was defined as the triceps skinfold–albumin index (TA). Harrell's C index, a time‐dependent receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC) were used to evaluate the prognostic performance of the TA and other indices. Optimal stratification was used to identify the thresholds to define a low TA, and the association of the TA with all‐cause mortality was evaluated using Kaplan–Meier analysis and Cox proportional hazard regression models.ResultsThe study enrolled 2408 women and 2726 men with a median age of 58.6 years and a median follow‐up of 44 months. A total of 607 women (TA < 49.9) and 817 men (TA < 45.6) were classified as having a low TA. The TA showed better discrimination performance (C index = 0.621, 95% confidence interval [CI] = 0.607–0.636) to predict mortality in patients with cancer cachexia than the handgrip strength, the nutritional risk index, the prognostic nutritional index, the controlling nutritional status index, the systemic immune‐inflammation index, the modified Glasgow prognostic score, and the TSF or albumin alone in the study population (all P < 0.05). The 1‐, 3‐ and 5‐year time‐dependent ROC analyses (AUC = 0.647, 0.625 and 0.630, respectively) showed that the TA had the highest prognostic value among all indices investigated (all P < 0.05). Univariate analysis showed that a lower TA was associated with an increased death hazard (hazard ratio [HR] = 1.859, 95% CI = 1.677–2.062), regardless of the sex and cancer type. Multivariable survival analysis showed that a lower TA was independently associated with an increased death hazard (HR = 1.381, 95% CI = 1.223–1.560). This association was significantly strengthened in patients who did not receive curative chemotherapy (HR = 1.491, 95% CI = 1.298–1.713), those who had higher serum total protein levels (HR = 1.469, 95% CI = 1.284–1.681) and those with better physical performance (HR = 1.453, 95% CI = 1.271–1.662).ConclusionsThis study defined and evaluated a new prognostic index, the TA, which may improve the selection of intervention strategies to optimize the survival of patients with cancer cachexia.
High physical activity alleviates the adverse effect of higher sedentary time on the incidence of chronic kidney disease
Authors: Oh Wonsuk , Cho Minhae , Jung Su Woong , Moon Ju‐Young , Lee Sang‐Ho , Hwang You‐Cheol , Kim Yang Gyun 
Published: December 2022

AbstractBackgroundLow physical activity (PA) increases the prevalence of chronic kidney disease (CKD). This study aimed to investigate the effects of PA and sedentary time (ST) on the changes in renal function and the development of CKD in the middle‐aged Korean population.MethodsFrom the Korean Genome and Epidemiology Study Database, 7988 participants in their 40s and 60s were identified and stratified by (1) PA: high‐PA (>24 MET‐h/day), moderate‐PA (9–24 MET‐h/day) and low‐PA (<9 MET‐h/day); and (2) ST: high‐ST (>6 h/day), moderate‐ST (3–6 h/day) and low‐ST (<3 h/day). Incident CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 following the Chronic Kidney Disease Epidemiology Collaboration equation.ResultsThe mean age of the participants was 52.0 years. The overall incidence of CKD was 16.8 per 1000 person‐years over a median of 12 years. The lower the PA and the higher the ST, the lower the baseline eGFR. Relative to the high‐PA, the coefficients of the annual eGFR decline were −0.12 (95% confidence interval [CI]: −0.26 to 0.001, P = 0.081) and −0.13 (95% CI: −0.27 to 0.01, P = 0.078) in the moderate‐ and low‐PA groups, respectively. Similarly, relative to the low‐ST, the coefficients of annual eGFR decline were −0.07 (59% CI: −0.19 to 0.05, P = 0.236) and −0.14 (95% CI: −0.28 to −0.01, P = 0.039) in the moderate‐ and high‐ST groups, respectively. Incident CKD was higher with lower PA (hazard ratio: high‐PA 1.00, moderate‐PA 1.13 [1.00, 1.28, P = 0.056] and low‐PA 1.25 [1.11, 1.24, P < 0.001]) and higher ST (hazard ratio: low‐ST 1.00, moderate‐ST 1.04 [0.94, 1.16, P = 0.440] and high‐ST 1.19 [1.05, 1.34, P = 0.007]). The high‐PA reduced the risk for the CKD development irrespective of the amount of ST.ConclusionsLow‐PA and high‐ST are risk factors for the development of CKD in the middle‐aged Korean population. High‐PA recovers high‐ST, inducing a harmful effect on the occurrence of CKD.
Noninvasive endoscopic hemostasis technique for post‐papillectomy bleeding using a novel self‐assembling peptide (with video)
Authors: Miyano Akira , Ogura Takeshi , Nishikawa Hiroki 
Published: December 2022

AbstractAlthough a novel hemostatic agent has been used for endoscopic mucosal resection in submucosal dissection, there are few case reports of its use in pancreato‐biliary endoscopic procedures. We describe a case of post‐endoscopic papillectomy bleeding in which endoscopic hemostasis was achieved using a novel hemostatic agent.
Allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma in Switzerland, 20 years of experience: 2001–2020
Authors: Simeunovic Helena , Dickenmann Martina , Nabergoj Mitja , Baldomero Helen , Masouridi‐Levrat Stavroula , Nair Gayathri , Schanz Urs , Passweg Jacob , Rovo Alicia , Chalandon Yves , Rebmann Ekaterina 
Published: December 2022

AbstractDespite the high cure rate with initial therapy, approximately 10% of Hodgkin lymphoma (HL) patients are refractory to initial treatment, and up to 30% of patients will relapse after achieving initial complete remission. Despite promising initial results of treatment by immune checkpoint inhibitors, most patients will eventually progress. We analyzed 62 adult patients with relapsed or refractory HL (rrHL) treated by allogeneic hematopoietic stem cell transplantation (allo‐HSCT) in one of three University Hospitals of Switzerland (Zurich, Basel, and Geneva) between May 2001 and January 2020. The primary endpoint was overall survival (OS). Secondary endpoints were relapse‐free survival (RFS), non‐relapse mortality (NRM), and relapse incidence, which were assessed in univariate analysis. The median follow‐up was 61 months (interquartile range 59–139). The 2‐ and 5‐year OS was 54% (standard error (SE) ±12) and 50.2% (SE ±13.3), respectively, and the 2‐ and 5‐year RFS was 40.7% (SE ±16.3) and 34.4% (SE ±19.0), respectively. NRM was 23.1% (SE ±2.2) and 27.4% (SE ±2.5) at 2 and 5 years, respectively. The cumulative incidence of relapse was 36.1% (SE ±5.6) at 2 years and 38.2% (SE ±6.6) at 5 years. Our analysis of allo‐HSCT outcomes in the context of rrHL shows encouraging OS and RFS rates, with the mortality rate reaching plateau at 50% at 2 years after allo‐HSCT. This confirms that allo‐HSCT still remains as a potentially curative option for half of patients with rrHL.