bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical inference for strong gravitational lensing observations in the presence of dark matter
Authors: Negrete‐Serrato Jose Salvador , Ureña‐López Luis Arturo 
Published: January 2023

AbstractWe study the properties of strong lenses generated by dark matter galaxy halos in the Universe and the statistical inference process to understand the density profile of the lens. For that, we used mock data of strong gravitational lenses using the publicly available software paltas, which is a pipeline based on the well‐known package lenstronomy and written in Python. The deflectors are modeled according to the so‐called elliptical power law lens profile, and the background cosmology is assumed to be that of the standard cosmological model ΛCDM. The generated lensing observations include the contribution of dark matter substructure in the form of either subhalos or halos along the line of sight. In both cases, the underlying profile is the Navarro‐Frenk‐White one, which corresponds to the cold dark matter model. Performing a statistical inference process on these mock observations, our final objective is to identify the influence of the substructure on the inferred parameters that describe the lens profile.
Effects of soybean varieties on life‐cycle greenhouse gas emissions of biodiesel and renewable diesel
Authors: Li Yuan , Xu Hui , Northrup Daniel , Wang Michael 
Published: January 2023

AbstractThis study presents a life‐cycle analysis (LCA) of the greenhouse gas (GHG) emissions of biodiesel (BD) and renewable diesel (RD) produced from soybean varieties with altered oil profiles and meal composition. The varieties evaluated include those with high oleic oil content (78% of oil being oleic oil vs. the current content of 25%), high lipid content (25% vs. the current content of 19%) or high protein content (45% vs. the current content of 35%). The results suggest that high‐oleic soybean oil could reduce GHG emissions of RD by 1 g CO2e/MJ by reducing hydrogen consumption in the hydro‐treating stage of RD production. With the default allocation method (mass‐based allocation between oil and meal), changes in lipid and protein contents have negligible impacts on GHG emissions of BD/RD pathways. Since high‐protein soybean meal has a higher nutrient value, we employed the market‐based allocation for sensitivity analysis. Assuming a market price of $1.17/dry kg and an average of two substitute feeds with similar protein contents (corn gluten and fish meal), the allocation factor for soybean meal increases from 63 to 81%. Compared with the results for the case with commodity soybean using mass allocation, GHG emissions could be 1.9 and 1.8 g CO2e/MJ lower for BD and RD, respectively. In addition to product‐level LCA, we employed a land‐based LCA to evaluate the effect of soybean properties on product slates with the same land area and the associated displacement of conventional products. The results suggest that high‐lipid soybeans may offer more GHG savings than other varieties as the higher BD/RD yield replaces more fossil diesel. © 2023 UChicago Argonne, LLC, Operator of Argonne National Laboratory and Northrup, Ag. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
Discovery of novel 4‐methylpiperidinyl benzamide derivatives as 5‐HT4 receptor agonist for the treatment of gastrointestinal disorders
Authors: Choi Sunho , Lee Min Jung , Ahn Kwang‐Hyun 
Published: January 2023

AbstractNovel 4‐methypiperidinyl benzamide derivatives were synthesized and evaluated for in vitro and in vivo prokinetic activities. In these derivatives, 3‐methoxypiperidine moiety of norcisapride, a pharmacophore of cisapride and DA‐6650, were replaced to 4‐methylpiperidinyl moiety without chiral center. Among these derivatives, Compound 28b had a potent 5‐HT4 receptor‐binding affinity (IC50 = 0.067 μM) and improved safety profiles without inhibiting CYP3A4 (IC50 = 7.272 μM) and blocking human ether‐à‐go‐go‐related gene (hERG) channel (IC50 > 10 μM). In vivo rat models, Compound 28b enhanced gastric emptying rate (68.2%) and showed over twofold increased defecation weight compared to the control. Moreover, it showed the alleviation effect of visceral hypersensitivity in the irritation rat model. Thus, Compound 28b was selected preclinical candidate as a prokinetic agent with a favorable safety profile for treating gastrointestinal disorders.
Throughput analysis in censoring‐based cooperative cognitive radio network with energy harvesting
Authors: Chandra Das Gopal , Saha Seemanti , Bhowmick Abhijit , Maity Santi P. 
Published: January 2023

SummaryAn energy harvesting (EH) and cooperative cognitive radio (CR) network (CRN) is studied in this paper where CR users transmit data through a primary user (PU) channel if the channel remains idle, else an optimal number CRs helps in transmission of PU. To achieve the optimum number of CRs (ONCR) involved in cooperation, a novel scheme based on a combination of channel censoring and total error is proposed. The performance of the proposed scheme is investigated under RF harvesting scenario. The EH is dependent on sensing decision and a CR source harvests energy from PU's RF signal. The harvested energy (HE) is split into two parts: One part is used by the CR network (CRN) for its own transmission, and the other part is used for supporting PU. The effect of the energy allocation factor on total throughput is also investigated. New expressions for optimal number of CRs and throughput are developed. The effect of network parameters such as sensing time, censoring threshold, and energy allocation parameter (EAP) on throughput is investigated. Impact of distance between nodes is also studied.
Superficial radiation therapy for nonmelanoma skin cancer: A review
Authors: Han Haowei , Gade Anita , Ceci Francesca M. , Lawson Alec , Auerbach Sloane , Nestor Mark S. 
Published: January 2023

AbstractBackgroundThe high prevalence of nonmelanoma skin cancer (NMSC) has become a global health‐care burden. Various modalities have been established to treat NMSC, with surgery being the mainstay approach. Superficial radiation therapy (SRT) has been in use for over a century to treat various conditions. Recent discussion among the dermatological community has promoted the use of SRT for the treatment of NMSC.Materials and MethodsA literature search was conducted using electronic databases (Medline, Pubmed, Embase, CINAHL, EBSCO) and textbooks, in addition to the authors' clinical experience with SRT.ResultsMultiple retrospective medical record reviews have deemed SRT to be highly effective and associated with minimal side effects. Moreover, SRT yields superior cosmetic results. Over the past decade, SRT has become a mainstay of dermatologist treatment of NMSC due to the new technological advances of the devices. These advances include improved controllability, precision in delivery, additional safety precautions, and have sparked a resurgence in research and clinical evidence on SRT. Most recent data have revealed that the NMSC cure rate is about 93%–100% with excellent 5‐year follow‐up data. Image‐guided SRT using ultrasound guidance may additionally improve cure rates in the future.ConclusionSRT has shown to be an effective option for NMSC. It can also be effectively used in the management of keloids. The limitations across most studies encompass localized patient selection and a predominance of retrospective reviews in the literature. Additional research is warranted to further support SRT's efficacy in clinical practice.
Nutrient loss to erosion responds to rain characteristics under transformed landscapes in the Río Grande basin, Colombian Andes
Authors: Suescún Diego , León Juan Diego , Villegas Juan Camilo , Correa‐Londoño Guillermo Antonio 
Published: January 2023

AbstractThe functioning of tropical montane ecosystems are key provider of environmental services. However, climate and land use change interactively affect the ecohydrological and biogeochemical processes that support the provision of such services. We evaluate the effect of land use/land coverand the seasonality and intensity of the rainfall on the ecological functions of erosion control and nutrient regulation in a gradient of human intervention in the Central Andes of Colombia. Our results show that soil erosion (kg/ha/year) was higher in the transitory crop (187.7), followed by the permanent crop (98.2), and much lower in the pasture (8.0) and native forest (7.2). Our results also indicate a differential effect of land use and rainfall seasonality on erosion and nutrient transport, both processes being significantly higher in crops and lower in forest, both for the wet and dry seasons. However, the relationships between erosion and rainfall intensity varied depending on the hydrological season (in the wet seasons, no linear model was significant, while in the dry seasons, linear models for maximum rainfall intensity were significant in both crops and in the oak forest, and linear models with mean intensity were significant for both types of crops). Nitrogen exhibited the highest rates of transport, which can have important implications for water and soil pollution. Nitrogen transport via erosion (g/ha/year) was consistent with erosion results, being higher in the transitory crop (399.9) and permanent crop (265.3) that in the oak forest (6.9) and pasture (6.8). These results indicate that converting forests affects the capacity of ecosystems to provide environmental services, which is further amplified by projections of climate change.
How accurately do adult patients report their absence seizures?
Authors: Pizarro Joao , O'Sullivan Suzanne , Walker Matthew C. 
Published: January 2023

AbstractWe depend upon self‐reporting to determine seizure frequency for epilepsy management decisions, but people often misreport their seizures. Here, we determined misreporting rates in adults with absence seizures, undergoing inpatient video‐EEG telemetry (VET) or outpatient ambulatory electroencephalography (aEEG). Under‐reporting rates were based on VET data, where behavior could be assessed, whilst over‐reporting was assessed using both VET and aEEG. Forty‐two patients (31 female and 11 males, median age 28.5 years) and 759 reported absence seizures were included in this study. Overall, only 24% of the 759 reported seizures had an associated EEG correlate, indicating a high over‐reporting rate, which occurred in 57% of patients. Age, sex, time of epilepsy, VET versus aEEG, epilepsy syndrome, or medication were not significant predictors of over‐reporting. In the VET group in which we could assess both over‐ and under‐reporting (22 patients), only 2 patients correctly reported their seizures, and patients were predominantly over‐reporters or under‐reporters, not both. Only 26% of 423 absence seizures were reported. Use of zonisamide or valproate was associated with under‐reporting, possibly through an impact on attention. These findings indicate that self‐reported absence seizures are a poor measure to use for treatment decisions due to both over‐ and under‐reporting.
Effect of spectrum measurement position on detection of Klason lignin content of snow pears by a portable NIR spectrometer
Authors: Wu Xin , Li Guanglin , Fu Xinglan , He Fengyun , Wu Weixin 
Published: January 2023

AbstractSnow pears are an important and widespread agricultural product that can relieve respiratory symptoms, constipation, and alcoholism. Lignin content (LC) has a direct and negative role on the fruit texture and taste of snow pears. Here, we studied the effect on the near‐infrared (NIR) spectroscopy determination of the LC in snow pears due to the position at which spectral measurements were obtained. NIR diffuse reflection spectra were collected from nine measurement positions on each sample by a portable NIR spectrometer. Partial least squares regression (PLSR) was used to develop spectrum compensation models of the LC for three local spectrum models, an average spectrum model, and a global spectrum model. The results indicated that the prediction accuracy of the LC was affected by the spectral measurement position. Compared with the local spectrum models and the global spectrum model, the average spectrum model had good prediction results. Next, synergy interval partial least squares, bootstrapping soft shrinkage, competitive adaptive reweighted sampling, genetic algorithm, and an improved variable stability and frequency analysis algorithm (VSFAA) method were used to select the most effective variables to build the PLSR model. The average spectrum calibration model established using the 10 effective variables selected by VSFAA reduced the influence of the variation of the spectral measurement position for LC prediction and achieved more promising results, with the correlation coefficient of calibration and prediction of 0.842 and 0.824, respectively. The root mean square error of cross‐validation and prediction were 0.736 and 0.694, respectively. The overall results showed that the average spectrum model based on the nine spectral measurement positions reduced the sensitivity to the variation of spectral measurement position for predicting the LC and combined the VSFAA variable selection algorithm to improve the accuracy and provide a robust model for prediction of LC in snow pears. Compared with the local spectrum position models and the global spectrum position model, the average spectrum position model combining the nine measurement positions (three stem‐calyx longitudes intersected three latitudes (stem, equator, calyx)) produced good prediction results and reduced the sensitivity to the variation of the spectral measurement position. The effective wavelengths (SNV‐VSFAA‐PLSR)‐average spectrum position model achieved good results, reducing the influence of the variation of the spectral measurement position for LC prediction, and the effective wavelengths selected from the average spectrum position model were helpful for offsetting the influence of the variation of spectral measurement position on the PLSR models based on the spectrum from the equatorial positions alone.
Nutritional qualities and antioxidant properties of ginger‐flavored biscuits developed from wheat, bambara groundnut, and plantain flour blends
Authors: Arogundade Toyin Joy , Oluwamukomi Matthew Olusola , Dada Mopelola Ajoke 
Published: January 2023

AbstractGlobal research toward the utilization of spices in plant‐based foods for the management of diseases resulting from the generation of free radicals has been progressive drastically. Ginger contains bioactive compounds with anti‐inflammatory and antioxidant properties. Hence, the effect of ginger on nutritional and antioxidant properties of biscuits produced from wheat, bambara groundnut, and plantain was investigated. Bambara groundnut flour (BF) and unripe plantain flour (PF) were used to supplement wheat flour (WF) to produce flour blends that were flavored with 2.5% ginger powder (GP) to produce ginger‐flavored biscuits, whereas 100% WF biscuit served as the control. The protein content of the biscuits ranged from 8.07% to 10.30%, whereas calcium (33.01–42.33 mg/100 g) was the most abundant mineral element in the biscuits. Essential amino acids, in vitro protein, and starch digestibility of the biscuits ranged from 30.03 to 35.31 g/100 g protein, 67.95% to 69.36%, and 51.86% to 52.35%, respectively. Total phenol and total flavonoid contents of the biscuits ranged from 2.86 to 4.48 mg GAE/g and 1.65 to 2.87 mg QE/g, respectively. However, there was no significant difference (p ≥ .05) in the overall acceptability of the biscuits. The ginger‐flavored biscuits demonstrated higher antioxidant properties than the control biscuit. Nevertheless, BFB‐1 (biscuit produced from 54.74% WF:13.68% BF:31.58% PF:2.5% GP) had the highest total phenol content, total flavonoid content, and antioxidant properties that could be attributed to its level of phenolic constituents. Hence, BFB‐1 could serve as a functional food for the management of oxidative stress‐related diseases.
Personality and contextual predictors of career advancement procrastination: An application of the social cognitive model of career self‐management
Authors: Zhu Lin , Hecht Tracy D. , Lefter Alexandru M. , Boies Kathleen 
Published: January 2023

AbstractThis research explored procrastination in the context of career self‐management, a construct that we refer to as career advancement procrastination (CAP). Drawing on the career self‐management model extension of social cognitive career theory, we hypothesized that personality traits (i.e., trait passive procrastination and trait active procrastination) and contextual factors (i.e., career resources and career barriers) have effects on passive CAP and active CAP via career self‐efficacy. Hypotheses were tested on a sample of employed Canadians in a two‐wave study (N = 201). As predicted, we found that trait passive procrastination was positively related to passive CAP, trait active procrastination was positively related to active CAP, and career barriers were related to both passive CAP and active CAP. We also found positive indirect effects of trait passive procrastination and career barriers, and negative indirect effects of career resources, on both passive CAP and active CAP via career self‐efficacy. Taken together, these findings suggest that companies can decrease CAP by helping employees curb their dispositional procrastination tendencies, as well as by reducing career barriers and increasing career resources, all of which should also aid in increasing employees' career self‐efficacy.
The role of immunotherapy and targeted therapy in the multimodal therapy for resectable lung cancer
Authors: Deboever Nathaniel , Eisenberg Michael , Chidi Alexis , Sepesi Boris 
Published: January 2023

AbstractAs the immunotherapeutic milieu in resectable nonsmall cell lung cancer continues to evolve, the field of thoracic oncology actively moves towards better patient selection based on biomarkers and oncogenic drivers. In this article, we review the current standard of oncologic care in this population and discuss the ongoing phase III clinical trials investigating the use of immunotherapy or targeted therapy in the perioperative period. We also discuss genotyping initiatives, biomarkers, and trial endpoints.
Prevalence, incidence and relative risk of cardiovascular disease risk factors in adults with atopic dermatitis: A systematic review
Authors: Thyssen Jacob P. , Ross Terres Jorge A. , Pierce Evangeline J. , Feely Meghan A. , Silverberg Jonathan I. 
Published: January 2023

AbstractAtopic dermatitis (AD) has been associated with cardiovascular disease (CVD). A better understanding of CVD risk factors in AD populations may help dermatologists better counsel their patients regarding potential risks and treatment choices. This systematic literature review evaluated the prevalence, absolute risk (i.e., incidence) and relative risk of CVD risk factors in adults with AD. MEDLINE, Embase and The Cochrane Library were searched for English‐language articles published between January 2005 and the search date (16–17 March 2021) using terms for AD, prevalence/risk and CVD risk factors. Observational studies that reported the prevalence, absolute risk and/or relative risk of CVD risk factors in adults with AD were eligible. Of the 1277 unique articles identified, 71 met the inclusion criteria. Most studies were cross‐sectional or retrospective cohort studies from Europe, North America or Asia; many used national databases. Studies were heterogeneous, with inconsistent definitions of AD and risk factors (especially smoking and obesity), different methodologies and different populations (e.g., ethnicity). Within most controlled studies, the prevalence of several risk factors, particularly obesity, hypertension and dyslipidemia, was higher for AD than for controls. Where assessed, the prevalence of most CVD risk factors increased with increasing AD severity. Relative risks varied across studies. Only nine studies reported the temporal relationship between AD and CVD risk factors. Six studies reported absolute or relative risk of developing CVD risk factors (diabetes, hypertension and smoking) in AD populations; only one of these reported an elevated risk (hypertension). Despite the high number of studies to date, conclusive data regarding the relationship between AD and many CVD risk factors are lacking, and additional, carefully designed, prospective studies are required.
Video content can be heard at https://onlinelibrary.wiley.com/doi/10.1002/jvc2.87none
Mechanistic understanding of diazotroph aggregation and sinking: “A rolling tank approach”
Authors: Ababou Fatima‐Ezzahra , Le Moigne Frédéric A. C. , Grosso Olivier , Guigue Catherine , Nunige Sandra , Camps Mercedes , Bonnet Sophie 
Published: January 2023

AbstractDiazotrophs are ubiquitous in the surface (sub)tropical ocean, where they sustain most new primary production. Several recent studies also report the presence of diverse cyanobacterial diazotrophs in the mesopelagic and bathypelagic ocean, suggesting that they gravitationally sink, potentially supporting organic matter export and the biological carbon pump. Yet, the mechanisms leading to their export are not elucidated. Here, we simulated the sinking of diazotrophs in the water column by using rolling tanks, and measured the aggregation capacity and sinking velocities of four globally distributed strains having different sizes, shapes, and abilities to produce transparent exopolymer particles (TEP): two filamentous diazotrophs (Trichodesmium erythraeum, Calothrix sp.) and two unicellular cyanobacterial diazotrophs (UCYN‐B, Crocosphaera watsonii) and (UCYN‐C, Cyanothece sp.). All diazotrophs tested, regardless their size and shape, were capable of forming aggregates and sunk, albeit at different velocities depending on the aggregation capacity. Overall, UCYN formed aggregates as large as those formed by the filamentous diazotrophs (7000–32,014 μm ESD, equivalent spherical diameter), and sunk at 100–400 m d−1, i.e., at the same velocity as filamentous diazotrophs (92–400 m d−1). Although TEP are generally considered as enhancers of aggregation, TEP did not clearly influence aggregation rates nor sinking velocities during our study. We conclude that diazotrophs may be important contributors to carbon export in the ocean and need to be considered in future studies to improve the accuracy of current regional and global estimates of export.