bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of pulsed electric current on the structural and mechanical behavior of 6016 aluminium alloy in different states of hardening
Authors: Dobras Daniel , Zimniak Zbigniew , Zwierzchowski Maciej 
Published: June 2023

Abstract
This study presents the effect of high current pulses on the structural and mechanical behavior of the 6016 aluminium alloy in three different states of hardening: naturally aged, super saturated, and annealed. The 6016 aluminium alloy was used for the first time in terms of electrically-assisted forming. The influence of the application of different current parameters on the material behavior was conducted. The study of electrically-assisted tensile tests showed that the application of current pulses results in a distinct response of the material, depending on the hardening state. Although in a hardened state, the mechanical properties and plasticity are deteriorated, in the solution treated state, they are improved. For the changes of the material properties is responsible the interaction of the flowing current with the precipitates and the aging process. The new parameters were proposed to describe the distinctions in the material properties between the different states of hardening of the aluminium alloy during the electrically-assisted tension. The material examination was conducted using light and scanning electron microscopy, using also electron backscattered diffraction methods. The application of, for example, the grain orientation spread parameter demonstrated the presence of recrystallized grains, in electrically-assisted specimens.
Eco-friendly agro-waste based geopolymer-concrete: a systematic review
Authors: Alaneme George Uwadiegwu , Olonade Kolawole Adisa , Esenogho Ebenezer 
Published: June 2023

AbstractNumerous scientific studies have been conducted, and a wide range of new inorganic geopolymer composite applications have emerged as a result. This innovative material can be made from agricultural waste sources rich in aluminosilicate, which provides best substitute for traditional cement in terms of both quality and cost. This paper presents the state-of-the-art review of deploying agro-wastes as precursor for geopolymer concrete with the view to aggregating the research studies of using agro waste ash-based geopolymer as the most auspicious, durable, inexpensive, user-friendly, and eco-beneficial construction materials for the long-term use. This paper thoroughly examines the rheological, workability, chemistry, and mechanical characteristics of agro-waste ash-based geopolymer concrete with emphasis on sugarcane bagasse and banana peels ash. Sugarcane and green bananas (matooke) play vital roles in East African agriculture, economy and food security. The effects micro-structures, curing conditions, molarity of metallic alkalis, proportioning of alkaline-binder ratio, aggregates content and size fractions effects on the behavior of geopolymer concrete were critically assessed. The study highlighted the abundance of these agro products which serve as staple food in East African region, therefore, it becomes imperative to recycle its waste to produce durable concrete by way of waste management strategy. As a vital component of the readily available building materials, they have a crucial role to play in providing the construction sector with a sustainable outlook while concluding that agro-wastes are potential material that could be a game changer for geopolymer concrete, a number of research gaps that worthy for further study were identified. The findings of this review further demonstrates that agro-waste derivatives when used as binder materials in geopolymer concrete can be a viable and sustainable alternative to conventional cementitious materials.
Word choice for writing: the nature and types of children’s meta-lexical awareness
Authors: Newton Moira , Jesson Rebecca , Parr Judy 
Published: June 2023

Abstract
Children’s increasing expertise in composition relies partly on word choice. Little is known about how children consider words as they write, their meta-lexical awareness, or about their choice of words for writing. In this study, we investigate children’s meta-lexical awareness, as one aspect of their metalinguistic awareness, which guides their word choices as they write. We describe how child writers express their meta-lexical awareness and how this might relate to writing achievement. We view language as functional in context of use following systemic, functional grammar theorists. We employ a mixed methods approach using writing achievement scores and a modified think aloud protocol to understand what children think about words as they write. Findings show that children develop increasing sophistication in the way they consider and choose words and that this relates to their writing achievement. The nature of children’s meta-lexical awareness and its relationship to writing achievement is theorised, adding to the growing body of research into the importance of metalinguistic awareness to children’s writing.
Rotated Transtensional Basins Formed During Back‐Arc Spreading in Japan: Simultaneous Rapid Tectonic Rotation and Basin Subsidence
Authors: Hosoi J. , Tanii Y. , Okada M. , Haneda Y. 
Published: June 2023

AbstractPrevious models of strike‐slip basins do not consider the rotation of the basin itself; however, we show that the Tanakura transtensional basin in Japan was rotated and propose that this basin rotation was related to rifting caused by back‐arc spreading. The Tanakura Basin was formed by displacement along the Tanakura Fault Zone, one of the major active transform faults during the opening of the Sea of Japan. We carried out paleomagnetic analyses and U–Pb dating of the Neogene Tanakura Basin fill rocks. We present a revised, high‐precision stratigraphic record for the Neogene Tanakura Basin fill sequence shows that vertical‐axis counter‐clockwise rotation occurred between ∼17.2 and ∼16.6 Ma. Comparison with paleomagnetic data from adjacent areas shows that rotation was restricted to the basin. In addition, the timing of basin rotation corresponds to the rifting phase of the Tanakura Basin, suggesting that rapid basin subsidence owing to rifting and rapid basin rotation owing to strike‐slip faulting occurred simultaneously. The Tanakura Basin has the characteristics of both rift and transtensional basins that have experienced rotation. This study reveals the detailed relationships between the development and rotation of the Tanakura Basin: rifting‐related subsidence accompanied by basin rotation. Rifting owing to back‐arc spreading may have been accompanied by tectonic basin rotation in Northeast Japan, leading to variations in the magnitude and age of rotation, as the rifting occurred at different times in different locations.
The Generalized Application of a New Surface Pressure Tendency Equation in Synoptic Weather Systems
Authors: Zhang Deyuan , Ma Zhanhong 
Published: June 2023

AbstractThe surface pressure tendency equation (SPTE) is an important theoretical tool in understanding the development of weather systems, with various forms being proposed over the past 100 years. In this study, a new version of the SPTE, which eliminates the explicit or implicit pressure tendency term on the right‐hand side, is applied to three typical synoptic weather systems in terms of tropical cyclones, explosive cyclones anticyclones, and two mesoscale systems in terms of squall lines and supercells based on numerical simulations. Results reveal promising performance of the new equation in understanding the surface pressure tendency of three synoptic systems, showing advantages in uncovering their dominant physical processes as well as inherent discrepancies. For the tropical cyclone, the latent heating is largely responsible for the surface pressure fall, whereas the surface pressure rise of the anticyclone is mainly fueled by the upper‐level advection of potential temperature. The leading factors for the explosive cyclone intensification demonstrate a transition from mid‐level diabatic heating at the early stage to upper‐level potential temperature advection related to stratospheric air intrusion during the later intensification period. For the squall line and supercell, however, local breakdown of hydrostatic balance can be as large as ∼10%, and consequently, caution should be taken when the equation is used in mesoscale systems, especially for the supercell. These results suggest that the new SPTE can be well applied in synoptic weather systems, and can provide new insights into their intensity evolutions and contributions of diverse physical processes.
Manganese in residential drinking water from a community-initiated case study in Massachusetts
Authors: Friedman Alexa , Boselli Elena , Ogneva-Himmelberger Yelena , Heiger-Bernays Wendy , Brochu Paige , Burgess Mayah , Schildroth Samantha , Denehy Allegra , Downs Timothy , Papautsky Ian , Clauss Henn Birgit 
Published: June 2023

Abstract
Background
Manganese (Mn) is a metal commonly found in drinking water, but the level that is safe for consumption is unknown. In the United States (U.S.), Mn is not regulated in drinking water and data on water Mn concentrations are temporally and spatially sparse.

Objective
Examine temporal and spatial variability of Mn concentrations in repeated tap water samples in a case study of Holliston, Massachusetts (MA), U.S., where drinking water is pumped from shallow aquifers that are vulnerable to Mn contamination.

Methods
We collected 79 residential tap water samples from 21 households between September 2018 and December 2019. Mn concentrations were measured using inductively coupled plasma mass spectrometry. We calculated descriptive statistics and percent of samples exceeding aesthetic (secondary maximum containment level; SMCL) and lifetime health advisory (LHA) guidelines of 50 µg/L and 300 µg/L, respectively. We compared these concentrations to concurrent and historic water Mn concentrations from publicly available data across MA.

Results
The median Mn concentration in Holliston residential tap water was 2.3 µg/L and levels were highly variable (range: 0.03–5,301.8 µg/L). Mn concentrations exceeded the SMCL and LHA in 14% and 12% of samples, respectively. Based on publicly available data across MA from 1994–2022, median Mn concentration was 17.0 µg/L (N = 37,210; range: 1–159,000 µg/L). On average 40% of samples each year exceeded the SMCL and 9% exceeded the LHA. Samples from publicly available data were not evenly distributed between MA towns or across sampling years.

Impact statement

This study is one of the first to examine Mn concentrations in drinking water both spatially and temporally in the U.S. Findings suggest that concentrations of Mn in drinking water frequently exceed current guidelines and occur at concentrations shown to be associated with adverse health outcomes, especially for vulnerable and susceptible subpopulations like children. Future studies that comprehensively examine exposure to Mn in drinking water and its associations with children’s health are needed to protect public health.
The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation
Authors: Domingo-Reinés Joan , Montes Rosa , Garcia-Moreno Adrián , Gallardo Amador , Sanchez-Manas Jose Manuel , Ellson Iván , Lamolda Mar , Calabro Chiara , López-Escamez Jose Antonio , Catalina Purificación , Carmona-Sáez Pedro , Real Pedro J. , Landeira David , Ramos-Mejia Verónica 
Published: June 2023

AbstractPediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience a relapse. It is not possible to improve prognosis only with further intensification of chemotherapy, as come with a severe cost to the health of patients, often resulting in treatment-related death or long-term sequels. To design more effective and less toxic therapies we need a better understanding of pediatric AML biology. The NUP98-KDM5A chimeric protein is exclusively found in a particular subgroup of young pediatric AML patients with complex karyotypes and poor prognosis. In this study, we investigated the impact of NUP98-KDM5A expression on cellular processes in human Pluripotent Stem Cell models and a patient-derived cell line. We found that NUP98-KDM5A generates genomic instability through two complementary mechanisms that involve accumulation of DNA damage and direct interference of RAE1 activity during mitosis. Overall, our data support that NUP98-KDM5A promotes genomic instability and likely contributes to malignant transformation.
Site-specific fabrication of a melanin-like pigment through spatially confined progressive assembly on an initiator-loaded template
Authors: Jeong Haejin , Lee Jisoo , Kim Seunghwi , Moon Haeram , Hong Seonki 
Published: June 2023

AbstractMelanin-like nanomaterials have emerged in surface biofunctionalization in a material-independent manner due to their versatile adhesion arising from their catechol-rich structures. However, the unique adhesive properties of these materials ironically raise difficulties in their site-specific fabrication. Here, we report a method for site-specific fabrication and patterning of melanin-like pigments, using progressive assembly on an initiator-loaded template (PAINT), different from conventional lithographical methods. In this method, the local progressive assembly could be naturally induced on the given surface pretreated with initiators mediating oxidation of the catecholic precursor, as the intermediates generated from the precursors during the progressive assembly possess sufficient intrinsic underwater adhesion for localization without diffusion into solution. The pigment fabricated by PAINT showed efficient NIR-to-heat conversion properties, which can be useful in biomedical applications such as the disinfection of medical devices and cancer therapies.
Quality evaluation of ground improvement by deep cement mixing piles via ground-penetrating radar
Authors: Shen Hongyan , Li Xinsheng , Duan Ruifeng , Zhao Yong , Zhao Jing , Che Han , Liu Guoxin , Xue Zhijia , Yan Changgen , Liu Jiwei , Jiang Chao , Li Boke , Chang Hong , Gao Jianqiang , Yan Yueying 
Published: June 2023

AbstractDeep cement mixing piles are a key technology for treating settlement distress of soft soil subgrade. However, it is very challenging to accurately evaluate the quality of pile construction due to the limitations of pile material, large number of piles and small pile spacing. Here, we propose the idea of transforming defect detection of piles into quality evaluation of ground improvement. Geological models of pile group reinforced subgrade are constructed and their ground-penetrating radar response characteristics are revealed. We have also developed ground-penetrating radar attribute analysis technology and established ground-penetrating radar technical system for evaluating the quality of ground improvement. We further prove that the ground-penetrating radar results integrating single-channel waveform, multi-channel section and attributes can effectively detect the defects and stratum structure after ground improvement. Our research results provide a rapid, efficient and economic technical solution for the quality evaluation of ground improvement in soft soil subgrade reinforcement engineering.
Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing
Authors: Brooks Dominique L. , Carrasco Manuel J. , Qu Ping , Peranteau William H. , Ahrens-Nicklas Rebecca C. , Musunuru Kiran , Alameh Mohamad-Gabriel , Wang Xiao 
Published: June 2023

AbstractPhenylketonuria (PKU), an autosomal recessive disorder caused by pathogenic variants in the phenylalanine hydroxylase (PAH) gene, results in the accumulation of blood phenylalanine (Phe) to neurotoxic levels. Current dietary and medical treatments are chronic and reduce, rather than normalize, blood Phe levels. Among the most frequently occurring PAH variants in PKU patients is the P281L (c.842C>T) variant. Using a CRISPR prime-edited hepatocyte cell line and a humanized PKU mouse model, we demonstrate efficient in vitro and in vivo correction of the P281L variant with adenine base editing. With the delivery of ABE8.8 mRNA and either of two guide RNAs in vivo using lipid nanoparticles (LNPs) in humanized PKU mice, we observe complete and durable normalization of blood Phe levels within 48 h of treatment, resulting from corrective PAH editing in the liver. These studies nominate a drug candidate for further development as a definitive treatment for a subset of PKU patients.
GepLiver: an integrative liver expression atlas spanning developmental stages and liver disease phases
Authors: Li Ziteng , Zhang Hena , Li Qin , Feng Wanjing , Jia Xiya , Zhou Runye , Huang Yi , Li Yan , Hu Zhixiang , Hu Xichun , Zhu Xiaodong , Huang Shenglin 
Published: June 2023

AbstractChronic liver diseases usually developed through stepwise pathological transitions under the persistent risk factors. The molecular changes during liver transitions are pivotal to improve liver diagnostics and therapeutics yet still remain elusive. Cumulative large-scale liver transcriptomic studies have been revealing molecular landscape of various liver conditions at bulk and single-cell resolution, however, neither single experiment nor databases enabled thorough investigations of transcriptomic dynamics along the progression of liver diseases. Here we establish GepLiver, a longitudinal and multidimensional liver expression atlas integrating expression profiles of 2469 human bulk tissues, 492 mouse samples, 409,775 single cells from 347 human samples and 27 liver cell lines spanning 16 liver phenotypes with uniformed processing and annotating methods. Using GepLiver, we have demonstrated dynamic changes of gene expression, cell abundance and crosstalk harboring meaningful biological associations. GepLiver can be applied to explore the evolving expression patterns and transcriptomic features for genes and cell types respectively among liver phenotypes, assisting the investigation of liver transcriptomic dynamics and informing biomarkers and targets for liver diseases.
Adaptive EWMA control chart using Bayesian approach under ranked set sampling schemes with application to Hard Bake process
Authors: Khan Imad , Noor-ul-Amin Muhammad , Khan Dost Muhammad , AlQahtani Salman A. , Sumelka Wojciech 
Published: June 2023

AbstractThe memory-type control charts, such as cumulative sum (CUSUM) and exponentially weighted moving average control chart, are more desirable for detecting a small or moderate shift in the production process of a location parameter. In this article, a novel Bayesian adaptive EWMA (AEWMA) control chat utilizing ranked set sampling (RSS) designs is proposed under two different loss functions, i.e., square error loss function (SELF) and linex loss function (LLF), and with informative prior distribution to monitor the mean shift of the normally distributed process. The extensive Monte Carlo simulation method is used to check the performance of the suggested Bayesian-AEWMA control chart using RSS schemes. The effectiveness of the proposed AEWMA control chart is evaluated through the average run length (ARL) and standard deviation of run length (SDRL). The results indicate that the proposed Bayesian control chart applying RSS schemes is more sensitive in detecting mean shifts than the existing Bayesian AEWAM control chart based on simple random sampling (SRS). Finally, to demonstrate the effectiveness of the proposed Bayesian-AEWMA control chart under different RSS schemes, we present a numerical example involving the hard-bake process in semiconductor fabrication. Our results show that the Bayesian-AEWMA control chart using RSS schemes outperforms the EWMA and AEWMA control charts utilizing the Bayesian approach under simple random sampling in detecting out-of-control signals.
Simulation study of cone-in-shell target for indirect-drive ion fast ignition concept under the theory of an effective interaction potential
Authors: Mehrangiz Mahsa , Khoshbinfar Soheil 
Published: June 2023

AbstractThe stopping power of charged particles released by the deuterium–tritium nuclear reactions has been extensively studied in the weakly to moderately coupled plasma regimes. We have modified the conventional effective potential theory (EPT) stopping framework to have a practical connection to investigate the ions energy loss characteristics in fusion plasma. Our modified EPT model differs from the original EPT framework by a coefficient of order $$1 + {2 \mathord{\left/ {\vphantom {2 {(5}}} \right. \kern-0pt} {(5}}\ln \overline{\Xi }),$$

1
+

2

/

(
5

ln

Ξ
¯

)
,

($$\ln \overline{\Xi }$$

ln

Ξ
¯

is a velocity-dependent generalization of the Coulomb logarithm). Molecular dynamics simulations agree well with our modified stopping framework. To study the role of related stopping formalisms in ion fast ignition, we simulate the cone-in-shell configuration under laser-accelerated aluminum beam incidence. In ignition/burn phase, the performance of our modified model is in agreement with its original form and the conventional Li-Petrasso (LP) and Brown-Preston-Singleton (BPS) theories. The LP theory indicates the fastest rate in providing ignition/burn condition. Our modified EPT model with a discrepancy of $$\sim$$
∼
9%, has the most agreement with LP theory, while that of the original EPT (with a discrepancy of $$\sim$$
∼
47% to LP) and BPS (with a discrepancy of $$\sim$$
∼
48% to LP) methods maintain the third and fourth contributions in accelerating the ignition time, respectively.
Flow investigation of the stagnation point flow of micropolar viscoelastic fluid with modified Fourier and Fick’s law
Authors: Naveed Khan Muhammad , Abbas Khan Aamir , Wang Zhentao , F. Alrihieli Haifaa , M. Eldin Sayed , Aldosari F. M. , E. Elseesy Ibrahim 
Published: June 2023

AbstractNon-Newtonian fluids are extensively employed in many different industries, such as the processing of plastics, the creation of electrical devices, lubricating flows, and the production of medical supplies. A theoretical analysis is conducted to examine the stagnation point flow of a 2nd-grade micropolar fluid into a porous material in the direction of a stretched surface under the magnetic field effect, which is stimulated by these applications. The stratification boundary conditions are imposed on the surface of the sheet. Generalized Fourier and Fick’s laws with activation energy is also considered to discuss the heat and mass transportation. To obtain the dimensionless version of the flow modeled equations, an appropriate similarity variables are used. These transfer version of equations is solved numerically by the implement of the BVP4C technique on MATLAB. The graphical and numerical results are obtained for various emerging dimensionless parameters and discussed. It is noted that by the more accurate predictions of $$\varepsilon$$
ε
and M, the velocity sketch is decreased due to occurrence of resistance effect. Further, it is seen that larger estimation of micropolar parameter improves the angular velocity of the fluid.