bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objective and subjective barriers to the effective pediatric iron deficiency anemia control: results of questionnaire assessment of pediatricians and parents
Authors: Fisyun Ivan V. , Kuznetsova Tatiana A. 
Published: May 2023

Background. Iron deficiency anemia (IDA) remains a pressing pediatric issue to date. Despite the availability of clinical guidelines and other publications that highlight the objective causes for the lack of effectiveness of treatment and prevention of IDA in children, the subjective reasons are unrenowned.Objective. The aim of the study is to evaluate health beliefs of pediatricians and parents on the problem of anemia in children to investigation into the objective and subjective causes for inadequate control of iron deficiency conditions in childhood.Materials and methods. In September 2022, single-step parallel survey of pediatricians and parents on the problem of IDA in children was conducted by random sampling technique using original questionnaires. The questions were formulated on five topics and related to a common understanding of the term “anemia”; priority reference sources; availability of diagnosis of IDA in medical institutions (MI); the position of pediatricians and parents on the treatment and prevention of IDA in children. Based on the results, the main subjective and objective barriers to the control of IDA in children are identified. The χ2 method was used for the comparative evaluation of the responses. The differences were considered significant at statistical significance of p < 0.05.Results. Pediatricians (n = 81) and parents (n = 363) from 23 members of the Russian Federation took the survey. Among the objective barriers to the IDA control in children, the low availability of serum ferritin in MI, difficulties of venous access in children, a shortage of a range of iron preparations for children on Russian market were revealed. The subjective barriers were the skepticism of pediatricians and parents about the necessity for conservative prevention of IDA; poor knowledge of the criteria for diagnosis IDA and completion of IDA therapy by pediatricians; insufficient independence and selectivity of pediatricians when prescribing iron preparations; orientation of the majority of parents (93.7%) to the opinion of doctors, along with the actual rarity of full-fledged conversations with a pediatrician (16.3%).Conclusion. The main limitation of this study was the random sample method inclusion of respondents due to the impossibility of conducting a full-fledged population study. Elimination of the revealed subjective and objective factors can contribute to improving the detection of IDA in children, early appointment and higher effectiveness of treatment, reducing the frequency of disease recurrences, as well as increasing the confidence of parents in pediatricians.
Wertschöpfungskette für digitale Identitäten
Authors: Handke Florian 
Published: May 2023

Digitale Identitäten ermöglichen sichere Systeme in vielerlei Hinsicht. Sei es durch den Nachweis der Authentizität oder als Grundlage für die Authentisierung, die Integrität durch Signaturen oder die verschlüsselte Kommunikation in vielen TCP/IPbasierten Industrieprotokollen wie OPC UA oder MQTT. Isoliert betrachtet sind die Mechanismen aussagekräftig und verständlich. Im Verbund über mehrere Integrationsstufen vom Komponentenhersteller über einen Integrator bis hin zum Betreiber, der mehrere Anlagen unterschiedlicher Hersteller teilweise über 20 Jahre betreibt, ergibt sich ein komplexes Konstrukt, das alle Beteiligten vor große Herausforderungen stellt. Die Herausforderung besteht darin, den gesamten Lebenszyklus von Identitäten zu betrachten und die Prozesse für das Management zu automatisieren. Ansätze, wie sie in der OPC-Spezifikation 10000-21 oder RFC8995 vorgestellt werden, können dabei helfen. Der Beitrag geht auf die Mechanismen, Restriktionen und die verschiedenen Phasen ein.
EKSISTENSI DAN PEROBLEMATIKA PELESTARIAN WAYANG KULIT PADA GENERASI MUDA KEC. RINGINREJO KAB. KEDIRI
Authors: Alfaqi Mifdal Zusron 
Published: May 2023

The younger generation has a big responsibility to continue the preservation of culture, one of which is wayang. The problems that occur in the interest of the younger generation with low prevalence in wayang performances require philosophical exploration to find out the basic problems and the strategies needed. The aims of this study are a) to describe the history and values contained in wayang kulit; b) Describe the existence of shadow puppets among the younger generation; c) Preservation of shadow puppets in Ringinrejo District, Kediri Regency. The method used in this research is descriptive qualitative. The results of the study show that a) the existence of wayang kulit is caused because there are problems in preserving wayang kulit due to basic problems; b) the existence of the younger generation in the industrial revolution era is based on factors not understanding the storyline brought by the dalang, not understanding the language used by the dalang, feeling bored and having no interest in wayang kulit art because it is not integrated with modern culture, when wayang kulit shows are relatively old, and wayang kulit is an ancient culture. The rapid development of technology and cultural exchange without boundaries requires the right strategy; c) Ringinrejo Village is trying to preserve it by holding wayang kulit performances on big days and as a place for approaching and learning wayang kulit to the younger generation. Generasi muda memiliki tanggung yang besar untuk meneruskan pelestarian budaya salah satunya wayang. Problematika yang terjadi minat generasi muda dengan prevalensi yang rendah atas pagelaran wayang membutuhkan penggalian secara filosofi untuk mengetahui permasalahan mendasar dan strategi yang dibutuhkan. Tujuan dari penelitian ini adalah a) Mendeskripsikan sejarah dan nilai yang terkandung pada wayang kulit; b) Mendeskripsikan eksistensi wayang kulit di kalangan generasi muda; c) Pelestarian wayang kulit di Kecamatan Ringinrejo Kabupaten Kediri. Metode yang digunakan dalam penelitian ini yaitu deskriptif kualitatif. Hasil penelitian menunjukkan a) eksistensi wayang kulit disebabkan karena terdapat problematika pelestarian wayang kulit terkendala masalah mendasar; b) eksistensi generasi muda atas era revolusi industri didasarkan atas faktor tidak memahami alur cerita yang dibawakan oleh dalang, tidak memahami bahasa yang digunakan dalang, perasaan bosan dan tidak ada ketertarikan pada kesenian wayang kulit karena kurang terpadu dengan kebudayaan modern, waktu pertunjukan wayang kulit yang relatif lama, dan wayang kulit merupakan kebudayaan yang kuno. Perkembangan teknologi dan pertukaran budaya yang berjalan secara cepat tanpa batas membutuhkan strategi yang tepat; c) Desa Ringinrejo berusaha melestarikan dengan menggelar pagelaran wayang kulit pada hari-hari besar dan sebagai tempat untuk pendekatan dan pembelajaran wayang kulit kepada generasi muda.
De la Santa Alianza a Putin: dos siglos de tentativas hegemónicas de Rusia
Authors: Alcalde Cardoza Javier 
Published: May 2023

Sostiene que el comportamiento internacional de Rusia en nuestros días puede entenderse revisando sus tendencias históricas. Encuentra que Rusia se convierte en potencia militar dominante en Europa en 1812 y con la Santa Alianza ensaya brevemente un liderazgo hegemónico, que incluye preeminencia en el campo de las ideas. Después de la guerra de Crimea y el Gran Juego, frente a Inglaterra, Rusia vuelve a buscar la hegemonía con la Revolución bolchevique y luego en la guerra fría. Como potencia resurgente, con Putin, persigue una hegemonía regional en lo que denomina Eurasia.
Las negociaciones climáticas de Lima a París
Authors: Acurio Rómulo 
Published: May 2023

Las negociaciones climáticas bajo la CMNUCC se dirigen este año a la cita de París para adoptar un nuevo acuerdo climático universal y legalmente vinculante. Este artículo resume los resultados de la Conferencia de Lima (diciembre 2014), que sentó las bases para las negociaciones de este año, e identifica los asuntos políticos más sensibles abordados actualmente por este complejo proceso. También resalta algunos objetivos y prioridades de la Presidencia peruana de la COP20.
La labor del Comité Jurídico Interamericano
Authors: Negro Alvarado Dante 
Published: May 2023

El presente artículo retoma publicaciones anteriores sobre la labor del Comité Jurídico Interamericano. En esta ocasión, nos ocuparemos de las labores de dicho órgano de la Organización de los Estados Americanos correspondientes a los años 2012, 2013 y 2014, en particular, al desarrollo de temas tan importantes para la agenda jurídica del sistema interamericano tales como el fortalecimiento del sistema interamericano de derechos humanos, las sociedades por acción simplificadas y la ley modelo propuesta por el Comité Jurídico en esta materia, la responsabilidad social de las empresas en el campo de los derechos humanos y el medio ambiente, la protección de bienes culturales en casos de conflicto armado y el contenido de la ley modelo propuesta por el Comité Jurídico en este tema, la diversidad cultural en el desarrollo del derecho internacional y laguía de principios elaborada por el Comité, entre otros temas.
In vivo Anticoccidial Efficacy of Calotropis procera Leaf Extract as an Alternative Treatment Against Eimeria papillate Infection in Mice
Authors: Murshed Mutee , Aljawdah Hossam M.A. , Mares Mohammed M. , Al-Quraishy Saleh 
Published: May 2023

Background: Coccidiosis is still a serious parasite illness caused by Eimeria pps in many areas throughout the globe. As a consequence of eimeria medication resistance. Coccidiosis needs new drugs that contain natural antiparasitic chemical compounds. This study was conducted to investigate the in vivo anti-coccidia activity of Calotropis pocera leaf extract (CPLE) against infection of mice with Eimeria papillate. Methods: The first and second mouse groups were not infected, while the third, fourth, fifth and sixth were given 1x103 E. papillate sporulated oocysts. The fourth and fifth groups received 100 and 200 mg/kg CPLE orally and the sixth received toltrazuril 25 mg/kg in physiological saline. On day 5 p.i., animals were slaughtered and jejunum samples were prepared. Result: CPLE phytochemistry revealed 13 chemical compounds. 200 mg/kg was the most efficacious dose, reducing oocyst discharge in mouse faces by 68% and parasite stages in jejunal sections. Infection by E. papillata in mice causes inflammation, epithelial vacuolation, villi loss and a decrease in goblet cell density. When infected mice were given CPLE, histological damage was reduced by 69% and goblet cell number was restored to near-control levels. The infected group lost weight owing to emesis. However, the treated group CPLE gained weight.
Higiene y lavado de manos: propuesta para pasar de lo básico a lo avanzado
Authors: Mora-Alvarado Darner A. , Portuguez-Barquero Carlos Felipe 
Published: May 2023

Se analiza el informe “Progresos en Materia de agua potable, saneamiento e higiene. Informe de actualización de 2017 y línea de base de los ODS” de la Organización Mundial de la Salud (OMS) y el Fondo de las Naciones Unidas para la Infancia (UNICEF), con los aportes que reportaron 232 países sobre indicadores de cobertura con agua gestionada en forma segura, saneamiento de aguas residuales e higiene básica. Tomando en consideración la integralidad e interdependencia entre los indicadores, se busca determinar cuántas y cuáles naciones utilizaron agua potable y jabón durante la práctica higiénica del lavado de manos. Con esto, se establece una propuesta nacional para la clasificación del “Servicio avanzado” en el lavado de manos, en el marco de la “Escalera de la higiene”; dicha clasificación resulta fundamental para prevenir las enfermedades infecciosas entéricas y respiratorias, como la pandemia por “Covid-19” provocada por el coronavirus “SARS-CoV-2”. Se identificó que 20 países (8,6%) aportaron datos de los indicadores propuestos, pero solo siete (35%) reportaron el uso de agua potable sin contaminación fecal y cloro residual, combindo con jabón; los restantes 13 países (65%) utilizaron agua de calidad desconocida. Se propone el uso de agua potable para evitar la exposición a una carga microbiana que, lejos de limpiar las manos hace lo contrario. Ante esto, el “Servicio avanzado” de higiene (lavado de manos) se debe realizar con agua sin contaminación microbiana y con cloro residual, para contribuir en la eficiencia del lavado de manos junto con el uso de jabón.
(In)segurança alimentar e nutricional e fatores associados em famílias chefiadas por mulheres beneficiárias do Programa Bolsa Família
Authors: Bortolanza Emanueli Dalla Vecchia de Campos , Schmitt Vania , Uchida Nancy Sayuri , Santos Emilaine Ferreira dos , Vieira Daniele Gonçalves , Mazur Caryna Eurich 
Published: May 2023

Introdução: A segurança alimentar e nutricional (SAN) é a garantia do direito ao acesso regular e permanente a alimentos de qualidade, em quantidade suficiente, sem comprometer o acesso a outras necessidades essenciais. Sabe-se que a má alimentação, é mais frequente nas mulheres e crianças em situação de vulnerabilidade social e com insegurança alimentar e nutricional (IAN). Objetivo: compreender o nível de IAN em beneficiárias do Programa Bolsa Família (PBF). Método: estudo transversal realizado com 71 famílias. Utilizou-se a Escala Brasileira de Insegurança Alimentar (EBIA) para avaliar a SAN, além do estado nutricional e a ingestão alimentar. Resultados: 88,73% (n=63) das famílias apresentaram IAN. Foram observados valores significativos entre as comparações de IAN grave e SAN nas famílias que recebem doação de comida, as que têm acesso apenas por doação de terceiros, e aquelas que fazem as compras prioritariamente fora do bairro (p<0,05). Quem está em IAN grave tem 1,4 vezes mais chance de não consumir o café da manhã e 2,2 vezes mais chance de não consumir frutas. Conclusão: Foi identificado um alto nível de IAN, o que sugere que devem ser realizadas ações que melhorem este quadro.
Geophysical Modeling and Its Contribution on the Reservoir Characterization of Al Baraka in El Gallaba Plain, South Egypt
Authors: Ebraheem Mohamed O. , Ibrahim Hamza A. , Ewida Hatem F. , Senosy Ahmed H. 
Published: May 2023

Summary
The early Cretaceous formations in recent years are considered significant potential hydrocarbon-bearing rocks in many rift basins such as Komombo, south Egypt. Therefore, this study is focused on the critical analysis and interpretation of well logging together with seismic reflection data on the Al Baraka petroliferous reservoir in the Komombo subbasin. The interpretation of these data was used to construct the first 3D geophysical models in this area which were subsequently interpreted in terms of their potential to be hydrocarbon-bearing or not. The 3D petrophysical models were deduced to illustrate the spatial distribution and propagation of the petrophysical properties (laterally and vertically) within the reservoir. Additionally, 3D seismic models were prepared to get a comprehensive, in-depth picture of how the productive hydrocarbon reservoir zones are structurally controlled in different depths. So, these models are crucial for explaining reservoir characteristics and providing supported geological reservoir models for precise reservoir performance prediction. This study aims to differentiate and determine hydrocarbon potential zones in terms of the petroleum system. The results of these progressive analyses showed that only two zones (C and D) in the Six Hills Formation are considered the most productive zones because they have a large thickness of sand bodies, low-water saturation values, high porosity, and high permeability. These zones are located in the northeastern and central parts of the studied area, which represent the depocenter of the subbasin. This evidence supported and confirmed the presence of petroleum accumulations in certain zones within the Six Hills Formation. Therefore, this work can give and encourage experts with adequate knowledge to understand the development of the rift basins in Komombo and other basins in middle and south Egypt.
Curcumin regulates cell proliferation and invasion of human triple-negative breast cancer Hs578T cells via the mTOR signaling pathway
Authors: Chen Ze , Li MengHan , Zhang Qing , He Tao , Gan Lin 
Published: May 2023

Abstract
Curcumin, a polyphenolic compound isolated from the herb turmeric rhizome, is of interest for its potent biological activity, and in vitro studies have shown that it has broad anticancer activity. We investigated the impact of curcumin on the proliferation, migration, and invasion of TNBC Hs578T cells and further explored the underlying mechanisms. It was confirmed that the proliferation and motility of curcumin-treated Hs578T cells were inhibited, and bioinformatic RNA sequencing techniques further complemented the results we obtained. Finally, the sequencing results were validated using western blot experiments. Thus, we confirmed that curcumin could inhibit the proliferation and cell motility of TNBC Hs578T cells through the mTOR signaling pathway and the migration and invasion of Hs578T cells through EMT, which provide a theoretical and experimental basis for the clinical treatment of TNBC with curcumin by complementing each other through multiple approaches.
Application of multi-criteria group decision-making for water quality management
Authors: AHVAZI AMIN KARBASI , Ebadi Taghi , Zarghami Mahdi , Hashemi Seyed Hossein 
Published: May 2023

Abstract
The water quality of the Haraz River basin has been adversely affected by various factors, including domestic sewage discharge, agricultural runoff, population density, and proximity to the Amol landfill. The presence of 11 point sources (PS) of pollution, primarily in the form of domestic sewage, has led to high concentrations of CBOD, COD, and ammonium in the downstream reaches of the river. To investigate the water quality of the basin, a one-dimensional water quality model, QUAL2Kw, was employed to simulate and calibrate the water quality along the river. The model was validated using river quality data collected during a period of low flow in September 2020 and February 2020. The simulation results reveal that the downstream water quality, as assessed using the IRWQIsc index, is relatively bad. To mitigate this issue, various scenarios for waste load allocation (WLA) were evaluated, including no treatment, primary treatment, advanced secondary treatment utilizing the Activated Sludge (AS) method, and advanced treatment via the Membrane Bioreactor (MBR) method. Utilizing the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and Fuzzy TOPSIS decision-making model, it was determined that the optimal solution was the implementation of secondary treatment utilizing the Activated Sludge method for the 11 PS of pollution, while still adhering to Iranian water quality standard.
Necrosis-associated long noncoding RNA for predicting prognosis in hepatocellular carcinoma
Authors: Wang Xin , Yang Jun , Ma Zhenglai , Hu Zhongjie 
Published: May 2023

Abstract
Background and aim Histiocellular carcinoma (HCC) ranks second in the world's most deadly diseases, with a high mortality rate. Unlike apoptosis, necroptosis causes the release of molecular factors that elicit an immune response. As of yet, it has not been fully investigated how necroptotic machinery interacts with tumor-infiltrating lymphocytes in HCC .
Methods 374 patients and 50 healthy controls were analyzed using TCGA gene expression profiles, long noncoding RNA data and clinical characteristics. By analyzing lncRNA-seq data from 374 patients with HCC, an investigation of the relationships between necroptosis-related genes and tumor-infiltrating cells was conducted. A two-step multivariate Cox model and an univariate Cox model were analyzed to predict the prognosis . Nomograms were generated by combining necroptosis-related gene signatures with clinical characteristics. An analysis of HCC for PD-L1 was examined along with tumor-infiltrating immune cells .
Results Necroptosis-related pathways were enriched in lncRNA expression profiles in HCC tissues. The gene signature associated with necroptosis significantly reduced the survival rate of high-risk patients . The necroptosis-related gene signature demonstrated a high degree of predictive ability for OS (AUC= 0.781). Low-risk subgroups had significantly fewer aDCs, macrophages, and Treg cells than high-risk subgroups. In addition, scores indicating risk were positively correlated with uncharacterized cells, cancer associated fibroblast, monocyte, Macrophage/Monocyte and T cell regulatory (Tregs).
Conclusions These results revealed that the immunogenetic role of necroptosis may be influential in HCC prognosis. Exploring new possibilities for diagnostics and immunotherapy, the immune environment which was associated with necroptotic signatures needs to be assessed further based on its specific composition and functional characteristics.
Testing a Deliberative Democracy Engagement Intervention to Increase Guideline-Concordance Among Oral Health Providers: Results from the DISGO Cluster-Randomized, Stepped-Wedge Trial
Authors: Polk Deborah , Shah Nilesh H. , Dawson Tim , Gruß Inga , Pihlstrom Daniel J. , Kaplan Charles D. , Guerrero Erick G. , Fellows Jeffrey L. 
Published: May 2023

Abstract
Background
Dental caries affects billions worldwide and in the U.S. is among the most prevalent noncommunicable diseases in both children and adults. Early in the caries process, it can be arrested by dental sealants, which are non-invasive and thus tooth sparing, however, few dentists have adopted this approach. Deliberative engagement processes enable participants to engage with diverse perspectives on a policy issue and develop and share with policy makers informed opinions about the policy issue. We examined the effects of a deliberative engagement process on the ability of oral health providers to endorse implementation interventions and to apply dental sealants.
Methods
Using a stepped wedge design, 16 dental clinics were cluster randomized, and 680 providers and staff were exposed to a deliberative engagement process that included an introductory session, workbook, facilitated small group deliberative forum, and post-forum survey. Forum participants were assigned to forums to ensure diverse role representation. Mechanisms of action examined included sharing voice and diversity of opinion. Three months after each clinic’s forum, the clinic manager was interviewed about implementation interventions deployed. There were 98 clinic-months in the non-intervention period and 101 clinic-months in the intervention period.
Results
Compared with providers and staff in small clinics, providers and staff in medium and large clinics more strongly agreed that their clinic should adopt two of the three proposed implementation interventions targeting the first barrier and one of the two proposed implementation interventions targeting the second barrier. Compared with the non-intervention period, in the intervention period providers did not place more sealants on occlusal non-cavitated carious lesions. Survey respondents reported sharing both promotive and prohibitive voice. From the beginning to the end of the forums, most forum participants did not change their opinions about the possible implementation interventions. At the end of the forums, there was no significant within-group variability in implementation interventions endorsed.
Conclusions
Deliberative engagement intervention may help clinic leadership identify implementation interventions when there is a challenging problem, a network of semi-autonomous clinics, and autonomous providers within those clinics. It remains to be determined whether there is a range of perspectives within clinics.
Trial Registration:
This project is registered at ClinicalTrials.gov with ID NCT04682730. The trial was first registered on 12/18/2020. https://clinicaltrials.gov/ct2/show/NCT04682730