bluuebunny/crossref_metadata_2025_split huggingface dataset:
International fitness scale (IFIS): association with motor performance in children with obesity
Authors: Puci Mariangela Valentina , Cavallo Caterina , Gatti Alessandro , Carnevale Pellino Vittoria , Lucini Daniela , Calcaterra Valeria , Zuccotti Gianvincenzo , Lovecchio Nicola , Vandoni Matteo 
Published: July 2023

Background
Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health; and compared with their normal-weight peers, these individuals tend to have a lower level of self-confidence, and consequently lower physical activity adherence. Due to these self-perceived barriers, the aim of our study was to evaluate the efficacy of an online training program on self-reported physical fitness (SRPF) in children with obesity (OB).

Methods
A total of 32 children with OB carried out physical fitness (PF) tests and were asked to complete the International Fitness Enjoyment Scale (IFIS) questionnaire. The physical fitness tests were the Standing Broad Jump (SBJ), the 6-Min Walking Test (6MWT) and the 4 × 10 m sprint test. Children participated in a 3-weekly 60-min training session through Zoom platform. Before the beginning of the training protocol, OB children were compared with normal weight (NW) ones for PF batteries and the IFIS questionnaire. Changes in performances after the training were assessed by paired Student t and Wilcoxon tests.

Results
After the online training program children increased their performance in 6MWT (mean difference (MD) = 54.93; p < 0.0001) in SBJ (MD = 10.00; p = 0.0001) and in 4 × 10 m sprint test (MD = −0.78; p < 0.0001). No differences were found in children’s physical fitness perception.

Discussion
Our study highlighted how a structured online training program can lead to improvements in PF of children with OB. Instead, the lack of differences in SRPF after the training suggests interesting questions to be explored on the aspects linked to self-perception. Therefore, even if our training protocol could not directly improve SRPF in children with obesity, the enhancement of their PF could be a starting point for achieving this result with a longer training period and consequently improve PA participation for children with OB.
Overconfidence and Herding Bias on Investment Decisions the Role of Risk Perception as a Mediator
Authors: Purwidianti Wida , Rahmawati Ika Yustina , Dwiyanti Retno 
Published: July 2023

Aims: The investment decision is essential in Small and Medium Enterprises (SMEs). The behavioral financial theory explains that behavioral biases and risk perceptions of SME owners will influence investment decisions. This study highlights the relationship between overconfidence and herding bias toward investment decisions mediated by Risk Perception.
Study Design: The research population is SME owners in Banyumas Regency. The sample used was 118 SME owners. The data was collected using a questionnaire distributed to SME owners.
Methodology: This study uses the PLS-SEM analysis tool. The method used to gather the data was purposeful sampling. Test the validity and reliability using the outer model. Hypothesis testing uses the inner model.
Results: The study proves that partial overconfidence and herding bias positively affect risk perception. Overconfidence, herding bias, and Risk Perception positively affect investment decisions. The research results have not been able to prove that there is a mediating effect of risk perception on the relationship between overconfidence and herding bias on investment decisions. This research has theoretical and practical implications. Theoretical implications, especially for developing financial behavioral theory in investment decisions. For practical implications for stakeholders in SME development, it is necessary to pay attention to the behavioral biases in SME owners.
Environmental Enrichment Improves Motor Function and Muscle Transcriptome of Aged Mice
Authors: Huang Wei , Bates Rhiannon , Zou Xunchang , Queen Nicholas J. , Mo Xiaokui , Arnold W. David , Ray Alissa , Owendoff Gregory , Cao Lei 
Published: July 2023

AbstractAging results in the progressive decline of muscle strength. Interventions to maintain muscle strength may mitigate the age‐related loss of physical function, thus maximizing health span. The work on environmental enrichment (EE), an experimental paradigm recapitulating aspects of an active lifestyle, has revealed EE‐induced metabolic benefits mediated by a brain‐fat axis across the lifespan of mice. EE initiated at 18‐month of age shows a trend toward an increased mean lifespan. While previous work described EE's influences on the aging dynamics of several central‐peripheral processes, its influence on muscle remained understudied. Here, the impact of EE is investigated on motor function, neuromuscular physiology, and the skeletal muscle transcriptome. EE is initiated in 20‐month‐old mice for a five‐month period. EE mice exhibit greater relative lean mass that is associated with improved mobility and hindlimb grip strength. Transcriptomic profiling of muscle tissue reveals an EE‐associated enrichment of gene expression within several metabolic pathways related to oxidative phosphorylation and the TCA cycle. Many mitochondrial‐related genes—several of which participate in the electron transport chain—are upregulated. Stress‐responsive signaling pathways are downregulated because of EE. The results suggest that EE improves motor function—possibly through preservation of mitochondrial function—even late in life.
Liposomes Co‐Delivering Curcumin and Colistin to Overcome Colistin Resistance in Bacterial Infections
Authors: Qin Chengyuan , Tang Ning , Gan Yingying , Zhao Huimin , Li Yuzhen , Tian Guo‐bao , Yang Yi Yan , Yuan Peiyan , Ding Xin 
Published: July 2023

AbstractAntibiotic colistin is the last line of defense against multidrug‐resistant (MDR) Gram‐negative bacterial infections. Emergence of colistin resistance in microbes is a critical challenge. Herein, curcumin is discovered, for the first time, to reverse the resistance phenotype of colistin‐resistant bacteria via a checkerboard assay. For the co‐delivery of curcumin and colistin, negatively charged poly(ethylene glycol)‐functionalized liposomes encapsulating both drugs (Lipo‐cc) are prepared. Killing kinetics and live/dead assays confirm the antibacterial activity of Lipo‐cc against colistin‐resistant bacteria, which is more potent than that of the free curcumin and colistin combination. Mechanistical studies reveal that Lipo‐cc restores the affinity of colistin for the bacterial membrane and improves the uptake of curcumin, which leads to reduced efflux pump activity, achieving a synergistic effect of colistin and curcumin. At the effective antibacterial dose, Lipo‐cc does not exhibit any toxicity. The therapeutic efficacy of Lipo‐cc is further demonstrated in an intestinal bacterial infection model induced with colistin‐resistant Escherichia coli. Lipo‐cc reduces the bacterial burden with over 6‐log reduction and alleviated inflammation caused by infection. Importantly, unlike colistin, Lipo‐cc does not affect the homeostasis of the intestinal flora. Taken together, Lipo‐cc successfully overcame colistin resistance, indicating its potential for the treatment of colistin‐resistant bacterial infections.
Personalized 3D‐Printed Scaffolds with Multiple Bioactivities for Bioroot Regeneration
Authors: Huang Yibing , Zhang Zhijun , Bi Fei , Tang Huilin , Chen Jiahao , Huo Fangjun , Chen Jie , Lan Tingting , Qiao Xiangchen , Sima Xiutian , Guo Weihua 
Published: July 2023

AbstractRecent advances in 3D printing offer a prospective avenue for producing transplantable human tissues with complex geometries; however, the appropriate 3D‐printed scaffolds possessing the biological compatibility for tooth regeneration remain unidentified. This study proposes a personalized scaffold of multiple bioactivities, including induction of stem cell proliferation and differentiation, biomimetic mineralization, and angiogenesis. A brand‐new bioink system comprising a biocompatible and biodegradable polymer is developed and reinforced with extracellular matrix generated from dentin tissue (treated dentin matrix, TDM). Adding TDM optimizes physical properties including microstructure, hydrophilicity, and mechanical strength of the scaffolds. Proteomics analysis reveals that the released proteins of the 3D‐printed TDM scaffolds relate to multiple biological processes and interact closely with each other. Additionally, 3D‐printed TDM scaffolds establish a favorable microenvironment for cell attachment, proliferation, and differentiation in vitro. The 3D‐printed TDM scaffolds are proangiogenic and facilitate whole‐thickness vascularization of the graft in a subcutaneous model. Notably, the personalized TDM scaffold combined with dental follicle cells mimics the anatomy and physiology of the native tooth root three months after in situ transplantation in beagles. The remarkable in vitro and in vivo outcomes suggest that the 3D‐printed TDM scaffolds have multiple bioactivities and immense clinical potential for tooth‐loss therapy.
Mechanism of Action of Oxazoline‐Based Antimicrobial Polymers Against Staphylococcus aureus: In Vivo Antimicrobial Activity Evaluation
Authors: Concilio Matilde , Garcia Maset Ramón , Lemonche Laia Pasquina , Kontrimas Vito , Song Ji‐Inn , Rajendrakumar Santhosh Kalash , Harrison Freya , Becer C. Remzi , Perrier Sébastien 
Published: July 2023

AbstractAntimicrobial‐resistant pathogens have reached alarming levels, becoming one of the most pressing global health issues. Hence, new treatments are necessary for the fight against antimicrobial resistance. Synthetic nanoengineered antimicrobial polymers (SNAPs) have emerged as a promising alternative to antimicrobial peptides, overcoming some of their limitations while keeping their key features. Herein, a library of amphiphilic oxazoline‐based SNAPs using cationic ring‐opening polymerization (CROP) is designed. Amphipathic compounds with 70% cationic content exhibit the highest activity against clinically relevant Staphylococcus aureus isolates, maintaining good biocompatibility in vitro and in vivo. The mechanism of action of the lead compounds against S. aureus is assessed using various microscopy techniques, indicating cell membrane disruption, while the cell wall remains unaffected. Furthermore, a potential interaction of the compounds with bacterial DNA is shown, with possible implications on bacterial division. Finally, one of the compounds exhibits high efficacy in vivo in an insect infection model.
A Hyperspectral Camouflage Colorant Inspired by Natural Leaves
Authors: Xie Dongjin , Zu Mei , Li Mingyang , Liu Dongqing , Wang Zi , Li Qingwen , Cheng Haifeng 
Published: July 2023

AbstractThe unmet spectral mimicry of foliar green in camouflage materials is hampered by the lack of colorants with similar spectral properties to chlorophyll, resulting in substantial risks of exposure from hyperspectral target detection. By drawing inspiration from leaf chromogenesis, a microcapsule colorant with a chloroplast‐like structure and chlorophyll‐like absorption is developed, and a generic bilayer coating is designed to provide high spectral similarity to leaves with different growth stages, seasons, and species. Specifically, the microcapsule colorant preserves the monomeric absorption of the internal phthalocyanine and features the manufacturability of conventional pigments, such as amenability to painting and patterning, and compatibility to different substrates. The pigmented artificial leaves successfully deceive the hyperspectral classification algorithm in a foliar background, and outperforming the state‐of‐art spectral simulation materials. This coloration strategy expands the knowledge base of the spectral fine tuning of composite colorants, which are essential for their application in spectral‐resolved optical materials.
A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer
Authors: Zhang Peng , Li Zhi , Cao Weiling , Tang Jingjie , Xia Yi , Peng Ling , Ma Jing 
Published: July 2023

AbstractBreast cancer is the most frequent malignancy affecting women, yet current therapeutic strategies remain ineffective for patients with late‐stage or metastatic disease. Here an effective strategy is reported for treating metastatic breast cancer. Specifically, a self‐assembling dendrimer nanosystem decorated with an antibody against programmed cell death ligand 1 (PD‐L1) is established for delivering a small interfering RNA (siRNA) to target 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1), a kinase involved in cancer metabolism and metastasis. This nanosystem, named PPD, is designed to target PD‐L1 for cancer‐specific delivery of the siRNA to inhibit PDK1 and modulate cancer metabolism while promoting programmed cell death 1 (PD‐1)/PD‐L1 pathway‐based immunotherapy. Indeed, PPD effectively generates simultaneous inhibition of PDK1‐induced glycolysis and the PD‐1/PD‐L1 pathway‐related immune response, leading to potent inhibition of tumor growth and metastasis without any notable toxicity in tumor‐bearing mouse models. Collectively, these results highlight the potential use of PPD as an effective and safe tumor‐targeting therapy for breast cancer. This study constitutes a successful proof of principle exploiting the intrinsic features of the tumor microenvironment and metabolism alongside a unique self‐assembling dendrimer platform to achieve specific tumor targeting and siRNA‐based gene silencing in combined and precision cancer therapy.
Sunflower‐Inspired Light‐Tracking System and Spatial Encryption Imaging based on Linear Flexible Perovskite Photodetector Arrays
Authors: Huang Rongqing , Wu Ketai , Li Wanjun , Huang Xinyue , Zhou Sitong , Jiang Shaowei , Fu Yong , Zhao Zhijuan , Mai Wenjie , Zhao Chuanxi 
Published: July 2023

AbstractLight‐tracking systems and wide‐angle imaging are garnering increasing interest in the field of artificial intelligence due to their benefits to improve the light collection efficiency. Perovskite photodetectors have become the mainstream choice for their high adsorption coefficient, flex‐compatible properties, and low‐cost solution process. However, the fabrication of precise angle‐sensitive flexible detectors remains challenging due to the uncontrollable deposition of photosensitive layers. Herein, wide‐angle‐sensitive linear flexible perovskite photodetector arrays are successfully fabricated. The device exhibits a broad range of 144°, high‐resolution of 2.8°, and long‐term stability of 3000 cycles. As a proof‐of‐concept demonstration, a sunflower‐inspired light‐tracking system with adaptive following performance is illustrated. Furthermore, spatially encrypted imaging is achieved using linear perovskite photodetector arrays coupled with algorithms. This work confirms the superiority of flexible perovskite photodetectors in angle‐sensing and encryption imaging.
On‐Chip Single‐Molecule Fluorescence Enhancement via Slotted Gallium Phosphide Nanodisks at Anapole States
Authors: Yang Yatao , Wang Yifan , Yan Yongxian , Cheng Weiren , Zhao Qiancheng , Li Yi 
Published: July 2023

AbstractSurface‐enhanced fluorescence of single emitters lies at the heart of single‐molecule DNA sequencers as well as quantum light sources. The state‐of‐the‐art metallic nanoapertures are impaled in a dilemma between enhancing radiative decays and minimizing nonradiative issues such as quenching and resistive heating. Here, lossless gallium phosphide slotted nanodisks are proposed that operate at anapole states by in‐plane excitation, precisely aligning the optical “hot spots” with fluidic focuses of zeptomolar sensing volume. Unlike traditional microscopic configurations, this proposed scheme excited via butt‐coupled in‐plane waveguides not only exhibits averagely 12.4× excitation enhancement growth for a single emitter located in the slot, but also enables precise manipulation of the local density of optical states which gives rise to 13.2× when QY0 = 0.003. Surprisingly, directional collection from the excitation waveguide appears in the optimal approach rather than the collection from a CMOS camera at the bottom. The overall on‐chip fluorescent enhancement is benchmarked with the four dyes’ colors, lowering the excitation power to 5.3% of contemporary zero‐mode waveguide (ZMW) devices.
Electronic and Magnetic Properties of Co‐Decorated Molecular Organic Network Adsorbed on Graphene
Authors: Abbasian Hamed 
Published: July 2023

AbstractFirst‐principles calculations based on density functional theory (DFT) are performed for investigating the electronic and magnetic properties of a heterostructure formed by Co‐decorated trimesic acid (TMA) self‐assembling network (SAN) adsorbed on graphene. The concentration and spatial position of Co adatom on graphene is regulated by the architecture of SAN. The obtained optimized geometry shows that Co adatom ends up at the top of a C atom on graphene in the heterostructure. The spin‐polarized calculations upon Co‐SAN/G, illustrate that Co adsorption on top site, which is favored by the self‐assembling network, causes an alternating change in the local density of states (LDOS) of graphene that consequently gives rise to sublattice symmetry‐breaking effects reflected in the different gap opening at K valleys. It is demonstrated that a single Co atom adsorbed on top of a C atom on graphene generates similar physical properties as Co‐SAN/G and, in fact, the SAN acts as a template for patterning Co on graphene without interfering with the magnetic properties originated from the adsorbate. Furthermore, Co atoms in the Co‐SAN/G structure, which are localized on just one sublattice type and separated by 10 Å in a triangular lattice, constitute ferromagnetically aligned spin centers.
Octupole Last‐Passage Algorithm for Charge Density on the Fichera‐Corner Conducting Surface
Authors: Jang Hoseung , Yu Unjong , Hwang Chi‐Ok 
Published: July 2023

AbstractIn a series of papers, it has been developing last‐passage algorithms such as last‐passage algorithm and off‐centered last‐passage algorithm on a flat conducting surface, quadrupole last‐passage algorithm on an L‐shaped conducting surface and so on, held at (non)constant potentials. In this paper, it further develops the last‐passage algorithms on the Fichera‐corner (cubic trihedral) conducting flat surface. To demonstrate the algorithm, it computes charge densities on the Fichera‐corner conducting surface in 3D space and finds that the results agree very well with the ones from the Given‐Hwang's original last‐passage algorithm on a flat surface. Compared with the Given‐Hwang's last‐passage algorithm, the octupole last‐passage one is very suitable for computing charge density near the corner of the Fichera‐corner conducting surface.
Simultaneous design and NMPC control under uncertainty and structural decisions: A discrete‐steepest descent algorithm
Authors: Palma‐Flores Oscar , Ricardez‐Sandoval Luis A. , Biegler Lorenz T. 
Published: July 2023

AbstractIn this article, we address the integration of design and nonlinear model‐based control under uncertainty and structural decisions for naturally ordered structures. We propose an algorithmic framework to determine the optimal location of process units or streams over an ordered discrete set that operates in closed‐loop with a model‐based controller. The formulation corresponds to a mixed‐integer bilevel problem (MIBLP) that is transformed into a single‐level mixed‐integer nonlinear problem (MINLP) using a KKT transformation strategy. In our methodology, the integer decisions are partitioned into subsets calledexternal variables, such that the MINLP is decomposed into an integer‐basedmasterproblem andprimalsubproblems with fixed discrete variables. Themasterandprimalproblems are solved using a Discrete‐Steepest Descent Algorithm (D‐SDA). We illustrate the discrete‐based methodology in a case study for a binary distillation column. The D‐SDA showed an improved performance compared to a benchmark continuous‐based formulation using differentiable distribution functions (DDFs).
Surface‐Controlled CdS/Ti3C2 MXene Schottky Junction for Highly Selective and Active Photocatalytic Dehydrogenation‐Reductive Amination
Authors: Han Yi‐Wen , Ye Lei , Gong Tian‐Jun , Fu Yao 
Published: July 2023

AbstractPhotocatalytic valorization and selective transformation of biomass‐derived platform compounds offer great opportunities for efficient utilization of renewable resources under mild conditions. Here, the novel three‐dimensional hierarchical flower‐like CdS/Ti3C2 Schottky junction (MCdS) composed of surface‐controlled CdS and pretreated Ti3C2 MXene is created for photocatalytic dehydrogenation‐reductive amination of biomass‐derived amino acid production under ambient temperature with unprecedented activity and selectivity. Schottky junction efficiently promotes photoexcited charge migration and separation and inhibits photogenerated electron‐hole recombination, which results in a super‐high activity. Meanwhile, CdS with the reduced surface energy supplies sufficient hydrogen sources for imine reduction and induces the preferential orientation of alanine, thus contributing superior selectivity. Moreover, a wide range of hydroxyl acids are successfully converted into corresponding amino acids and even one‐pot conversion of glucose to alanine is easily achieved over MCdS. This work illustrates the mechanism of crystal orientation control and heterojunction construction in controlling catalytic behavior of photocatalytic nanoreactor, providing a paradigm for construction of MXene‐based heterostructure.
Molecular studies regarding colon cancer cell line (HCT116) treated by new ruthenium and palladium complexes
Authors: Mohamed Magda F. , Kashmiry Alaa A. , Hassan Safaa S. 
Published: July 2023

Ru(H2dtpa) (H2O) and Pd (DME)Cl2 were prepared, and their structures were confirmed by different structural tools. [Ru(H4dtpa) (cysteine)] Cl was separated as a model for the interaction of Ru (III) complex containing DTPA ligand with its corresponding most active amino acid and the geometrical parameters for the ternary complex and their constituent ligands are evaluated. Cytotoxicity was examined for both complexes against different cancer cell lines (HCT116, A549 and Mcf7). They were tested against a normal human lung cell line (W138). In addition, both complexes ensured cytocidal, not cytostatic effect. Several molecular tools were utilized in order to figure out the mechanism of action that two complexes followed to inhibit human colon cancer (HCT116) cell line. Gene expression analysis, cell cycle assay, genomic DNA analysis, and apoptosis were a molecular techniques that proved both Ru(H2dtpa) (H2O) and Pd (DME)Cl2 complexes were promising and effective chemotherapeutic agents against colon carcinoma in this current study. So, authors recommended more in vivo future studies should be done to make sure of complexes bioactivity and safety before they would be used commercially.