bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional network‐building for complexity: A region‐oriented policy response to increasing and varied demands for older person care in the Netherlands
Authors: van der Woerd Oemar , Wallenburg Iris , van der Scheer Wilma , Bal Roland 
Published: April 2023

AbstractNetworks are increasingly seen as promising generic solutions to complex public problems. This article analyzes network‐building in action within a specific regional setting as an attempt to cope with increasing and varied demands for older person care, studying everyday organizational and policy activities of actors. Drawing on a qualitative in‐depth case study of a regional network in Zeeland—the most aging region in the Netherlands—our findings illuminate how this network is created, nurtured, and sustained, and the particularities and complexities this involves. Our practice‐based approach demonstrates that network‐building requires the ongoing work of many agents within organizational contexts, as well as the outside interference of stakeholders to make the network “work” within the wider population of networks, institutional context, and geographical place. This highlights to network literature the importance of place‐based interventions that characterize how a network develops and pursues opportunities to come up with suitable responses to local needs.
Temporal population structure of rubber tree powdery mildew pathogen Erysiphe quercicola in Hainan, China
Authors: Cao Xueren , Xiao Ying , Han Qiaohui , West Jonathan S. , Daquan Luo 
Published: April 2023

AbstractRubber tree powdery mildew, caused by the obligate pathogen Erysiphe quercicola, is a major threat to rubber tree plantations worldwide. To investigate the temporal changes in the population structure of E. quercicola, diseased samples were collected at three disease epidemic stages (overwinter, early epidemic and late epidemic) from three counties in Hainan, China. Population structure was assessed using 16 polymorphic microsatellite markers. Both permutational multivariate analysis of variance (PERMANOVA) and analysis of molecular variance (AMOVA) indicated that there were significant differences among the population structure of E. quercicola at different epidemic stages. Furthermore, the late epidemic populations had higher genetic diversity than the other two stages. Discriminant analysis of principal components (DAPC) and STRUCTURE analysis showed that E. quercicola samples grouped into four clusters. One of the clusters included only samples from the late epidemic stage, while the other three clusters included samples from all three sample stages. Further analysis confirmed that there were significant (p = 0.001) genetic differences among these four clusters. As the teleomorph stage of E. quercicola has not yet been reported on rubber tree, these findings suggest that the epidemic of rubber tree powdery mildew is not only established by local inoculum sources, but also may be by inoculum drifting from other plantations or through host jumps from other hosts.
Regulation of proteolysis in bovine cumulus cells with possible inclusion of proton pump activators
Authors: Coruhlu Ipek , Tepekoy Filiz 
Published: April 2023

AbstractThe aim of this study was to reveal the effects of V‐ATPase proton pump activation on lysosomal acidity and protein degradation in cultured cumulus cells. Cumulus cells from bovine ovaries were cultured in the presence of 10 and 50 μM doses of V‐ATPase proton pump activators PIP2, PMA and DOG for 12 and 24 h. At the end of the culture period, the level of protein degradation was evaluated through DQ‐Red‐BSA analysis and the lysosomes were detected through a fluorescent probe. In addition, total and phosphorylated MAPK1/3 and AKT protein levels of cumulus cells were determined through Western blotting. PIP2 and PMA were shown to increase protein degradation and lysosomal acidity in cultured bovine cumulus cells, whereas DOG did not have any significant effects on these cells. Total and phosphorylated MAPK and AKT protein levels were higher in PIP2 and PMA groups compared with the control and DOG. It was concluded that particular proton pump activators can enhance protein degradation and lysosomal acidification in cultured bovine cumulus cells without having detrimental effects on cell signalling members required for cell viability and proper functioning. Due to the cellular interactions, increasing the lysosomal activity in cumulus cells in the culture environment could also affect the removal of protein aggregates in the oocytes. This strategy could be effective for improving in vitro maturation of the oocytes by providing proteostasis.
Measuring climate change adaptation policy output: Toward a two‐dimensional approach
Authors: Schulze Kai , Schoenefeld Jonas J. 
Published: April 2023

AbstractAs jurisdictions across the globe step up their efforts to adapt to climate change, it is important to assess progress by taking stock of and comparing adaptation policy. However, scholars and practitioners are struggling to conceptualize and measure adaptation policy. In this article, we propose a new two‐dimensional framework to measure public adaptation policy output, namely, the Climate Adaptation Policy Index (CAPI). The index combines multiple indicators from two core interdependent dimensions, namely, an institutionalization dimension focusing on strategic plans and administrative capacities for adaptation; and a measures dimension capturing concrete adaptation measures in relevant action areas such as in green and open spaces, transport infrastructure, buildings, public education, and disaster management. Our approach is extensive but feasible and may be adjusted for use in different contexts and policy areas. We probe our approach at the local level using original survey data from a diverse sample of 211 municipalities located in the state of Hessen in central Germany. A factor analysis suggests that the two dimensions constitute a meaningful measurement of municipal adaptation policy output. A cluster analysis identifies five groups of municipalities representing different stages of adaptation policy progress in Hessen. Finally, a regression analysis examines potential determinants of local adaptation policy making such as the size and wealth of municipalities. The results highlight the potential of the CAPI for analyzing both the state and the making of municipal adaptation policy.
A continuous analog of the binary Darboux transformation for the Korteweg–de Vries equation
Authors: Rybkin Alexei 
Published: April 2023

AbstractIn the Korteweg–de Vries equation (KdV) context, we put forward a continuous version of the binary Darboux transformation (aka the double commutation method). Our approach is based on the Riemann–Hilbert problem and yields a new explicit formula for perturbation of the negative spectrum of a wide class of step‐type potentials without changing the rest of the scattering data. This extends the previously known formulas for inserting/removing finitely many bound states to arbitrary sets of negative spectrum of arbitrary nature. In the KdV context, our method offers same benefits as the classical binary Darboux transformation does.
Educational strategies for oral assistance for the disabled and their effects on dentistry students’ formation: A systematic review
Authors: Silva Fernanda Luiza , Tavares Sandro Junio de Oliveira , Silveira Flávia Maia , Antunes Leonardo Santos , Antunes Lívia Azeredo Alves , Assaf Andréa Videira 
Published: April 2023

AbstractAimsThis systematic review aimed to analyze the influence of educational strategies for oral health care for Persons with disabilities (PwDs) on the technical, ethical, and social training of undergraduate dental students.Methods and resultsAn extensive search was performed in the following databases: Cochrane, Embase, PubMed, Scopus, Web of Science, LILACS/BBO and OpenGrey database. Observational, nonrandomized, and quantitative comparisons before and after some type of educational strategy in undergraduate dentistry was included. The risk of bias was assessed using the risk of bias in nonrandomized intervention studies (ROBINS‐I) tool. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Nine were included and suggested that a significant improvement was observed in the technical training of undergraduate dental students although there was no consensus on the acquisition of ethical/social competences after the application of educational strategies. The included studies presented a moderate to serious risk of bias, and the certainty of evidence for both, technical and ethical/social evaluative constructs, as very low.ConclusionAlthough studies show that awareness regarding PwD significantly increases technical skills in dental students, the evidence is poor due to the high risk of bias and inconsistency observed in both the technical and ethical/social constructs; further studies on this topic are therefore essential. Prospero: (CRD42021288463).
OsWRKY10 extensively activates multiple rice diterpenoid phytoalexin biosynthesis genes to enhance rice blast resistance
Authors: Wang Liping , Fu Jingye , Shen Qinqin , Wang Qiang 
Published: April 2023

SUMMARYPhytoalexin is the main chemical weapon against pathogens in plants. Rice (Oryza sativa L.) produces a number of phytoalexins to defend against pathogens, most of which belong to the class of diterpenoid phytoalexins. Three biosynthetic gene clusters (BGCs) and a few non‐BGC genes are responsible for rice diterpenoid phytoalexin biosynthesis. The corresponding regulatory mechanism of these phytoalexins in response to pathogen challenges still remains unclear. Here we identified a transcription factor, OsWRKY10, which positively regulates rice diterpenoid phytoalexin biosynthesis. Knockout mutants of OsWRKY10 obtained by CRISPR/Cas9 technology are more susceptible to Magnaporthe oryzae infection, while overexpression of OsWRKY10 enhances resistance to rice blast. Further analysis revealed that overexpression of OsWRKY10 increases accumulation of multiple rice diterpenoid phytoalexins and expression of genes in three BGCs and non‐BGC genes in response to M. oryzae infection. Knockout of OsWRKY10 impairs upregulation of rice diterpenoid phytoalexin biosynthesis gene expression by blast pathogen and CuCl2 treatment. OsWRKY10 directly binds to the W‐boxes or W‐box‐like elements (WLEs) of rice diterpenoid phytoalexin biosynthesis gene promoters to regulate gene expression. This study identified an extensive regulator (OsWRKY10) with broad transcriptional regulatory effects on rice diterpenoid phytoalexin biosynthesis genes, providing insight into the regulation of chemical defense to improve disease resistance in rice.
Cold storage of whole blood in an additive solution containing apoptotic and necrotic inhibitors
Authors: Reddoch‐Cardenas Kristin M. , McIntosh Colby , Barrera Gema , Bynum James A. 
Published: April 2023

AbstractBackgroundWhole blood (WB) reigns superior to component therapy for the treatment of hemorrhagic shock on the battlefield. Though cold storage of WB offers a shelf life of 21 to 35 days, storage lesions and the potential for blood wastage remain. Storing WB in an additive solution (AS) containing apoptotic inhibitors may help preserve blood cell viability and improve blood quality over extended cold storage.Study Design and MethodsNon‐leukoreduced WB was obtained from healthy individuals and dosed with: AS, AS+Necrostatin‐1 (AS+N1), AS+Boc‐D‐fmk (AS+B; apoptosis inhibitor), AS+Q‐VD‐OPh (AS+Q; apoptosis inhibitor), and Control (0.9% saline). Blood bags were kept refrigerated (1°–6°C) for 21 days. Bags were tested on days 0, 7, 14, and 21 for complete blood count, metabolism, clot formation, aggregation function, platelet activation, and red blood cell quality.ResultsPlatelet count was better preserved in all AS‐containing samples. All groups displayed increased glucose consumption and lactate production with storage. Furthermore, all groups displayed a similar decline in clot strength (max amplitude) over the 21‐day storage period. Bags that received AS displayed greater preservation of GPIIb expression and lower phosphatidylserine exposure. P‐selectin expression was increased in all AS groups.DiscussionTreatment of hemorrhagic shock with WB transfusion is logistically simpler than component therapy. Results from our study suggest that refrigerated WB stored with an AS containing apoptotic and necrotic inhibitors helps better preserve platelet count but does not improve platelet function. The future development of WB ASs is warranted to optimize both platelet quality and hemostatic function.
A Python Implementation of a Robust Multi-Harmonic Balance With Numerical Continuation and Automatic Differentiation for Structural Dynamics
Authors: S. Martins Tiago , Trainotti Francesco , Zwölfer Andreas , Afonso Frederico 
Published: April 2023

Abstract
This work presents a tool that performs simulations in nonlinear vibration analysis. It can be used to appraise the structure's functionality and to determine the loading effects. Oscillations are fundamental in nature, appearing in practical engineering applications. General nonlinear problems hardly have analytical solutions, requiring sophisticated techniques to reach approximate solutions. This toolbox is an open-source Python implementation of a robust multiharmonic balance with predictor–corrector numerical continuation, Newton–Raphson root-solver, and forward automatic differentiation with dual numbers, which is a novelty. It shows promising converging robustness, especially in the construction of frequency response curves, when dealing with polynomial as well as sharp nonlinearities, such as dry-friction.
Numerical Investigation of Conjugate Natural Convection From a Vertical Cylindrical Open Cavity
Authors: Mohamad Shafiq , Rout Sachindra Kumar , Senapati Jnana Ranjan , Sarangi Sunil Kumar 
Published: April 2023

AbstractAn extensive numerical analysis is performed on a vertical cylindrical open cavity made of aluminum with varying thicknesses to study conjugate natural convection. The key purpose of this study is to evaluate the effect of cylinder wall thickness on natural convection at the outer wall of the cylinder, which is coupled to the inner cylinder wall that has a constant temperature of 450 K and the ambient air which temperature is 300 K. The Navier–Stokes equations, continuity equation, and energy equations are solved numerically. The finite volume method is applied in the computational domain that includes the vertical cylindrical open cavity by using ansys-fluent 18 to specify the properties of flow and exchange of thermal energy. A couple of pertinent parameters are used for the numerical investigation like Rayleigh number within laminar regime (within range 104–108), aspect ratio (undefined proportion of length to diameter of the cylinder (L/D)) of the vertical cylindrical open cavity (2, 4, 6, 8, 10), and cylinder wall thickness (0, 1, 2, 3, 4 mm). This study presents the velocity vector field and thermal plume contours. An approximate Nusselt number to Rayleigh number equation is developed for the vertical cylindrical cavity within the range of Rayleigh numbers addressed by this work.
Positioning Accuracy Prediction and Tolerance Allocation of Cycloid Reducers Based on a BDTCA Model
Authors: Wang Xincheng , Li Luyang , Ye Jianfeng , Yang Xuefeng , Wang Huaming , He Xigang 
Published: April 2023

Abstract
The reliability of the prediction model and test scheme for the positioning accuracy of the cycloid reducer is very important. This paper proposes an efficient bidirectional drive tooth contact analysis (BDTCA) model that can simultaneously analyze the forward transmission error (TE), the reverse TE, and the global lost motion (GLM) of a cycloid drive, considering a variety of manufacturing and assembly errors (including pin assembly error). The results of the BDTCA case studies show that the sensitivity of the pin radius error to the GLM considering pin assembly error is twice that of the sensitivity without considering pin assembly error. Therefore, the influence of pin assembly error on the GLM cannot be ignored. The equivalent error model for BDTCA is established based on Latin hypercube sampling and template measurement, and the positioning accuracy of 50,000 reducer virtual prototypes is predicted. According to the positioning accuracy requirements, the tolerance allocation is optimized by using the discrete particle swarm optimization algorithm, and the qualified rate after optimization is significantly improved. A bidirectional drive test (BDT) scheme is proposed according to the BDTCA model. By comparing with the traditional hysteresis curve test, the superiority of the BDT scheme and the rationality of the tolerance allocation optimization are proved. The sensitivity of the pin radius error to the GLM is obtained through a comparison BDT, which verifies the correctness of the BDTCA model considering pin assembly error. This BDTCA model provides more reliable theoretical guidance for the design and manufacture of cycloid reducers.
Heat Transfer Enhancement in Laminar Pipe Flow Using Al2O3–Water Nanofluid and Twisted Tape Inserts
Authors: Bairagi Santinath , Roy Ranendra , Mandal Bijan Kumar 
Published: April 2023

Abstract
In this study, an attempt has been made to carry out a numerical investigation using water-based Al2O3 nanofluid, flowing through a circular tube under constant inlet temperature and constant heat flux conditions in the laminar flow regime. The water-based Al2O3 nanofluid is used in a circular plain tube first, and then, this process is repeated for the same tube fitted with twisted tape inserts of twist ratio 1.85 at Reynolds numbers ranging from 680 to 2030. For the numerical analysis, ANSYS FLUENT is used to solve three-dimensional conservation equations of mass, momentum, and energy. The simulated results indicate that when twisted tape is used, heat transfer rates increase significantly with the use of nanofluid. In the case of nanofluid with the plain tube, only 10–24% enhancement in heat transfer rate is noted. On the other hand, almost 27–45% increase in heat transfer is observed compared to that with only water when twisted tape is inserted into it. Also, the friction factor increases as the nanoparticle volume fraction increases. However, the effect on the heat transfer rate is more significant than that on the friction factor. The best thermohydraulic performance factor achieved is 2.1 using nanofluids with a 5% volume fraction of the nanoparticles at a high Reynolds number when twisted tape is also inserted.
Thermo-Economic Comparative Study and Multi-Objective Optimization of Supercritical CO2-Based Mixtures Brayton Cycle Combined With Absorption Refrigeration Cycle
Authors: Ma Ya-Nan , Hu Peng 
Published: April 2023

Abstract
In this paper, a novel system based on the combination of a supercritical recompression Brayton cycle (SRBC) and LiBr-H2O absorption refrigeration cycle (ARC) is proposed, in which ARC utilizes the waste heat of SRBC for cooling and further reduces the main compressor inlet temperature. The potential of using xenon and krypton as additives for the supercritical CO2 Brayton cycle is explored via comparative analysis. The results show that CO2/Krypton is more suitable to be the working fluid of the combined system because of its higher thermal efficiency and lower costs. The effects of the operating parameters and mass fraction of krypton on the thermo-economic performance of the combined system are discussed. Multi-objective optimization is applied to simultaneously optimize the thermal efficiency and total product unit cost of the system. Compared with the stand-alone cycle, the combined system can improve the cycle efficiency over a wide temperature range. The exergy efficiency of SRBC/ARC using CO2/Krypton (0.64/0.36) increased from 0.638 to 0.688, from 0.653 to 0.665, and from 0.586 to 0.646 at ambient temperature T0 = 10, 25, 35 °C, respectively, increasing by 7.84%, 1.84%, and 10.24% compared with that of SCO2RBC. The combined system will achieve its full potential when the critical temperature of the working fluid is close to the ambient temperature.
Reduction of Pressure Pulsation for Pump-Turbine by Variable Speed Operation
Authors: Li Yulan , Yang Weijia , Huang Yifan , Ma Weichao , Zhao Zhigao , Yang Jiebin , Cheng Yongguang , Qian Zhongdong , Yang Jiandong 
Published: April 2023

Abstract
Variable speed operation has emerged as a key direction in the development of pumped storage technology. Maintaining pressure pulsation within the control range is particularly critical for ensuring operational safety of variable-speed pumped storage plants (VSPSPs). However, there is limited research on the relationship between pressure pulsation for pump-turbine and variable speed operation. This paper presents amplitude distribution diagrams of pressure pulsation, obtained from processing model test results of a real VSPSP. Different conditions of variable speed operation are simulated by a numerical model to analyze the influence of operating trajectory on pressure pulsation, and the intensity of pressure pulsation is quantitatively evaluated. According to the results, when the initial speed or speed command increases, the trajectory passes through more regions with high-amplitude pressure pulsation and gradually moves toward the S-shaped region, leading to pressure oscillations. When speed command reduces, maximum pressure pulsation at the volute inlet and in the draft tube can be reduced by 82.18% and 63.24% at most, and the evaluation score can be increased by 28.77%. The findings of this study can offer theoretical guidance for operating VSPSPs.
Fatigue Damage Study of Steel–Aluminum Friction Stir Welding Joints Based on Equivalent Damage Model
Authors: Wu Haifeng , Xu Sha , Chen Hao , Yang Yali , Gao Kun , Li Yongfang 
Published: April 2023

Abstract
An equivalent damage model was established to study the fatigue damage behavior of steel–aluminum friction stir welding (FSW) joints. Internal defects of friction stir welding joint under various cyclic loading stages were observed by X-ray microcomputed tomography (X-CT). For the characteristics of defects of the steel–aluminum FSW joints, a simplified method of defects considering key parameters is proposed, and then, the defect model is established. The FSW joint model was established based on the steel–aluminum boundary contour identified by using image processing techniques. Based on the defect model and the FSW joint model, the equivalent damage model was developed. The equivalent damage model was subjected to finite element analysis and compared with the test using strain amplitude as the damage variable. The equivalent damage model can be used to assess fatigue damage in steel–aluminum FSW joints, which provides some theoretical basis for fatigue life prediction.