Regenerative surgical therapy in a frequent cannabis consumer: A case study
Authors: Bozal Carola B. , Sosa Marina , Aguirre Sofía , Rodríguez Cristina , Adrados Mariano , Gómez Mariel , Romanelli Hugo J. 
Published: January 2025

AbstractBackgroundThere is substantial evidence that smokers present a less favorable response following regenerative periodontal surgery. However, there are no reports to date on the response to regenerative procedures in chronic cannabis smokers. In the present case study, we discuss the periodontal outcomes of reparative and regenerative surgical treatment in a cannabis consumer patient with generalized stage III grade C periodontitis.Methods and ResultsWe report the case of a young adult cannabis consumer patient diagnosed with generalized stage III grade C periodontitis who had a probing depth (PD) of ≥ 4 at 18% of sites and of ≥ 7 mm at 12% of sites and radiographically confirmed generalized interproximal bone loss with horizontal and angular defects that reached the middle and apical third of the roots. An appropriate sequence of therapy based on the recommendations in the Clinical Practice Guideline (CPG) involving reparative and regenerative surgical procedures (steps 1–3) was followed. Clinical outcomes at 6 months included a decrease in PD of up to 7 mm and radiographic evidence of newly formed bone in the bony defects.ConclusionThe present case study demonstrates the use of regenerative periodontal procedures as part of a stepwise treatment approach, with different interventions at each step, to successfully manage intrabony periodontal defects in a healthy young adult male cannabis consumer.Key points
Smoking is a well‐documented dose‐dependent risk factor for periodontal disease, with a demonstrated negative effect on periodontal therapy outcomes. However, the usefulness of regenerative periodontal therapy in cannabis smokers has not been established to date. This case presents new information in that it is the first report to show that appropriate periodontal treatment can stabilize the periodontal disease and that regenerative therapies were successful in healing intrabony periodontal defects in a healthy young adult cannabis user.
The keys to successful management of this case are:

Attention to detail in all aspects of therapy.
Patient compliance as a co‐therapist by maintaining effective plaque control.
Patient acceptance of supportive care recommendations.

The primary limitations of this case study are:

The main limitation of this study is that a single clinical case study is too small to draw conclusions about regenerative treatment in patients who use cannabis.
The follow‐up assessment times were not sufficient to determine the long‐term success of regenerative surgery.
Patient compliance with oral hygiene recommendations and supportive care are key to achieving long‐term success in regenerative therapy.

Plain language summaryBackground: Smokers have a worse response to regenerative periodontal surgery. There are no reports on how cannabis smokers respond to regenerative procedures. This case study discusses how periodontal surgery worked in a young adult patient with severe periodontitis who was a frequent cannabis user.After 6 months of an appropriate sequence of therapy including strict regenerative surgical procedures, there was new bone filling in the bony defects.Conclusions: This case shows that regenerative periodontal procedures can successfully treat intraosseous periodontal defects in a healthy young adult male cannabis user.