bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT characteristics of bronchopulmonary abnormalities caused by pepper aspiration
Authors: Liang Zhang-rui , Fu Bin-jie , Xiao Yang , Li Yi-shi , Chu Zhi-gang 
Published: July 2023

Abstract

Purpose: To investigate the computed tomography (CT) characteristics of bronchopulmonary abnormalities caused by pepper aspiration for improving diagnosis.
Materials and methods: From January 2016 to September 2022, 28 adult patients with confirmed obstructive pneumonia caused by pepper aspiration were enrolled. The CT characteristics of bronchial changes and pulmonary lesions caused by pepper were analyzed and summarized.
Results: Among the 28 patients, the most common symptom was cough (26, 92.9%), followed by expectoration (23, 82.1%). Bronchoscopy examination revealed that the pepper was mainly located in the right lower lobe bronchus (18, 64.3%), followed by the left lower lobe bronchus (5, 17.9%). In combination with bronchoscopy results, the pepper in bronchus was manifested as circular or V/U-shaped high density, localized soft tissue, and flocculent opacification in 8 (28.6%), 16 (57.1%), and 3 (10.7%) cases on CT images, respectively. The bronchial wall around the pepper was thickened with localized occlusion (19, 67.9%) and stenosis (9, 32.1%). Regarding the adjacent bronchi without pepper, extensive wall thickening with stenosis and/or occlusion were found in 23 (82.1%) cases. Distal pulmonary lesions frequently involved two or three segments (21, 75.0%) and mainly presented as patchy consolidation or atelectasis (24, 85.7%).
Conclusion: In combination to history of eating pepper and clinical symptoms, bronchopulmonary abnormalities caused by pepper should be highly suspected if U/V shaped and annular high density or localized soft tissue density was detected in the lower lobe bronchus, with extensive bronchial wall thickening, stenosis, or occlusion, and consolidation or atelectasis in multiple distal lung segments.
Development of Novel Preclinical Model of Frostbite Injury-Induced Chronic Pain Using Deep Frozen Magnets
Authors: Ummadisetty Obulapathi , . Akhilesh , Gadepalli Anagha , Chouhan Deepak , Tiwari Vinod 
Published: July 2023

Abstract
Frostbite is a devastating condition that majorly affects the quality of life of military veterans and people residing at high altitudes. Pain in extreme cold conditions drives protective behavior against noxious cold injury, but when unattended it leads to ischemia followed by tissue damage leading to chronic pain. There has been an increase in the development of pre-clinical models for studying frostbite, but utilizing these models for pain evaluation is ill suited. The major hurdle in the development of novel therapeutics for the treatment of frostbite injury-induced chronic pain is the unavailability of well-established preclinical models. In this work, we have used deep freeze magnets to induce the frostbite and carried out the pharmacological validation phases including face, predictive and constructive to develop the frostbite induced pain model. We have quantified the pain components like allodynia and hyperalgesia by multiple behavioral assays. Molecular studies revealed a significant increase in oxidative stress and microgliosis marked by an increase in protein expression of IBA1 followed by ICAM1 and TNF-α in the dorsal root ganglion and spinal cord. We also found that peripheral microgliosis leads to an increase in the levels of proinflammatory cytokines in the spinal cord which sensitized the different nociceptors. In DRG of frostbite rats, nociceptors such as TRP channels and neuropeptides were found to be upregulated. Although NR2B was upregulated in the DRG its expression in the spinal cord remained unchanged. Interestingly our findings exclude the role of NMDA receptors in frostbite-induced chronic pain in the spinal cord. Treatment with ibuprofen (25, 50, and 100 mg/kg, i.p.) leads to significant restoration in behavioral, biochemical, and molecular alterations in frostbite rats as compared to the vehicle-administered group. The frostbite rat model successfully demonstrated the standard pharmacological paradigm like face, predictive and constructive validity and has a potential of being utilized to quantify pain parameters like allodynia and hyperalgesia in frostbite-induced chronic pain and to screen future treatment modalities.
High-risk groups of Neonatal Lupus Erythematosus in term infants: a birth cohort study
Authors: Jingran Ma , Zhenghong Li , Hongmei Song , Lejia Zhang 
Published: July 2023

Abstract
Purpose: This study aims to analyse the clinical characteristics and risk factors of high-risk groups of neonatal lupus erythematosus (NLE) in term infants.
Methods: The high-risk groups of NLE whose mothers were positive of anti-SSA, SSB or U1RNP antibodies during pregnancy were enrolled. They were born from February 2013 to February 2020, with a gestational age not less than 37 weeks. We analyzed their clinical data from birth to 24 months after birth.
Results: A total number of 105 cases of NLE high-risk groups were included. Among them, 30 cases were diagnosed with NLE (NLE group) and 75 cases were not (non-NLE group). The affected systems of the NLE group included dermal (13.3%), hepatic (76.0%), and hematological system (43.3%). Hepatic involvement, anemia and thrombocytopenia could not emerge until 60 days, 41 days and 22 days after birth in some cases. The systems involvement could be cured within 3 to 12 months after birth. The clearance time of specific autoantibodies was 12 months after birth. There was no significant difference in clinical characteristics of babies and their mothers between the two groups, neither of the positive rate or clearance time of specific autoantibodies.
Conclusion: After standardized prenatal health care, there is still a high risk of dermal, hepatic, or hematological system involvement for high-risk groups of NLE. There are no specific indicators to predict whether the babies will develop to NLE or not. All of them need to be followed up closely within one year after birth.
Multi-objective optimization of concave radial forging process parameters based on response surface methodology and genetic algorithm
Authors: Du Zun , Xu Wenxia , Wang Zhaohui , Zhu Xuwen , Wang Junshi , Wang Hongxia 
Published: July 2023

Abstract
In order to improve the forming quality of the forging and reduce the forging cost in the concave radial forging process. In this paper, the influence of process parameters (radial reduction Δh, rotation angle β, friction coefficient μ) on the forging process is investigated by numerical simulation, and the trade-off between the objective functions (strain homogeneity 𝐸, forging load 𝐹) is achieved by a multi-objective optimization method. First, sample points for different combinations of process parameters were obtained by the central composite experimental design. Then the mathematical model between the process parameters and the objective function was established using the response surface method, and the model was subjected to variance analysis and sensitivity analysis. Finally, the optimal process parameter combination was obtained according to the NSGA-II algorithm and the satisfaction function. The optimization results were also verified by finite element simulations. The optimized process combination: Δℎ=0.25 𝑚𝑚, 𝛽 = 21.68°, 𝜇 = 0.05. The corresponding 𝐸 and 𝐹 are 0.241367 and 577.029, respectively. Compared with the initial process, the standard deviation of the overall strain is reduced by 14.25% and the forging load is reduced by 1.76%. The results indicate that the quality of the forgings was significantly improved while the forging cost was reduced to some extent.
Prevalence and correlates of severe anxiety in patients with first hospitalization for major depressive disorder combined with dyslipidemia: a large sample cross-sectional study
Authors: Yin Huimin , Zhang Yanting , Liu Xuebing , Li Yi , Ma Jun 
Published: July 2023

Abstract
Background: Anxiety symptoms and dyslipidemia are common comorbidities in patients with major depressive disorder (MDD), and there are complex pathophysiologic as well as clinical mechanisms underlying the association between the three. In this study, we investigated the prevalence and associated factors of severe anxiety in first-time hospitalized patients with MDD with dyslipidemia.
Methods: We included 708 patients with major depressive disorder with comorbid dyslipidemia and collected their sociodemographic and general clinical data as well as biochemical parameters such as lipids, thyroid function and blood glucose. We also completed the Hamilton Anxiety Scale (HAMD), Hamilton Depression Scale (HAMD), Positive Symptom Scale (PSS) and Clinical General Impression Scale (CGI) to assess their clinical symptoms.
Results: The prevalence of severe anxiety disorder in MDD patients with dyslipidemia combined with first hospitalization was 11. 02%. HAMD score, PSS score, history of suicide, body mass index (BMI), thyroid-stimulating hormone (TSH) level, and tetra-iodothyronine (FT4) level were the risk factors for the development of severe anxiety disorders in patients with MDD who were comorbid with dyslipidemia. Higher HAMD scores and TSH level may exacerbate the development of severe anxiety symptoms.
Conclusion: This study reports and identifies the prevalence of anxiety symptoms in first-time hospitalized MDD patients with comorbid dyslipidemia, as well as risk factors for anxiety symptoms and severity of anxiety symptoms, and these identified factors may be potentially useful and informative for preventing and intervening in severe anxiety in this target population.
Crispr-Cas9-based lncRNA interference and activation identified aberrant expression of MYC- regulated ST8SIA6-AS1 promotes tumorigenesis and metastasis in hepatocellular carcinoma
Authors: Liu Xue-Qian , Jiang Dong , Liu Yang , Xie Kun , Zhao Yi-Jun , Liu Fu-Bao 
Published: July 2023

Abstract
Background
Long noncoding RNAs (lncRNAs) participate in the formation, progression, and metastasis of cancer. This study aimed to explore the roles of lncRNA ST8SIA6-AS1 in the initiation and progression of hepatocellular carcinoma (HCC) and elucidate the underlying regulatory mechanisms.
Methods
Fifty-six in-house pairs of HCC tissues were included in this study and the ST8SIA6-AS1 RNA level were determined by real‑time PCR. The knockdown and overexpression of ST8SIA6-AS1 in HCC cell lines were performed by Crispr-Cas9-based gene repression and activation. The effects of LncRNA ST8SIA6-AS1 on the biological behavior of HCC cells were determined in vitro and in vivo. Luciferase reporter assays, ChIP qPCR, and co-IP assays were performed to detect the binding sites and biological behavior of MYC and FOXA1 on chromatin. In this study, databases ENCODE and GEPIA were invoked to analyze the regulatory mechanisms of ST8SIA6-AS1 expression.
Results
Here, the results showed that the expression of ST8SIA6-AS1 is limited to the testes and prostate, but not liver tissue, in physiological states, significantly increased in HCC. This finding was validated in multiple HCC cell lines and 56 in-house pairs of HCC tissues. Functionally, high-efficiency Crispr-Cas9-based knockdown of ST8SIA6-AS1 revealed that ST8SIA6-AS1 knockdown attenuated the proliferation, and decreased the migration and infiltration of HCC cells. ST8SIA6-AS1 knockdown also significantly reduced the growth rate of subcutaneous and orthotopic HCC tumors. Conversely, Crispr-Cas9-based ST8SIA6-AS1 overexpression significantly improved the oncogenic characteristics of HCC cells. These results suggest that aberrant ST8SIA6-AS1 expression enhances the oncogenic characteristics in the liver. Further analysis showed that ST8SIA6-AS1 upregulation was regulated by the direct binding of transcription factor MYC to the − 260 bp to + 155 bp and + 1003 bp to + 1312 bp region of the ST8SIA6-AS1 transcription start site, a segment with high H3K27 acetylation. MYC knockdown or treatment with the BET bromodomain inhibitor JQ-1 significantly reduced ST8SIA6-AS1 RNA expression in HCC cells.
Conclusion
Aberrant ST8SIA6-AS1 expression in HCC is mediated by MYC and FOXA1, which plays an oncogenic role in HCC. And ST8SIA6-AS1 could serve as a molecular marker for HCC diagnosis.
Psychological and Socio-ecological correlates of 12-month Suicide behavior among Junior High school students in the Greater Accra Region of Ghana.
Authors: Azasu Enoch , Quarshie Emmanuel , Messias Erick , Larnyoh Marcus , Ali Elizabeth , Joe Sean 
Published: July 2023

Abstract
In Ghana, we know little about the epidemiology of suicide ideation, plan and attempts among junior high school (JHS) students in Ghana including the years preceding high school. This study explores the onset, characteristics, and recent patterns of 12-month suicide behavior among Ghanaian junior high school (JHS) students. Paper based surveys were administered to a sample (n = 800) of junior high school students in the Greater Accra region of Ghana. Self-reported measures on suicide ideation, plan and attempt as well as several psychological and psychosocial factors related to mental health, substance use, poverty, sexual behavior, interpersonal relationships, and family structure were employed. Bi-variate, Multivariate and Logistic regression analysis were performed using Statistical Package for the Social Sciences (SPSS version 25). This study found that 1 out of 5 adolescents have experienced suicide ideation in the last 12 months. Girls had significantly higher 12-month (χ2 = 3.5, p < 0.05) suicide ideation rates than boys. More importantly, the study found stress significantly increasing the odds of suicide behaviors in the last 12 months (β = 1.14; CI = 1.05–1.24, p < 0.05) and parental support significantly reducing the odds of suicide behaviors in the last 12 months (β = 0.86; CI = 0.81–0.91, p < 0.05). Additionally, we found significant associations between sexual intercourse, dating, hunger, substance use, suicide stigma and suicide behaviors. This finding highlights a potential emerging suicide crisis among preteens which warrants attention. Additional studies are needed to observe these increasing trends, identify risk, protective and precipitating factors to help prevent suicide among these children.
Fabrication and optical properties of the oxygen-ion implanted waveguides in Er 3+ -doped germanate glasses
Authors: Zhao Jie , Zhu Ze-Rui , Lu Yan , Ni Xiao , Zhang Liao-Lin , Wang Xiang-Fu , Liu Chun-Xiao 
Published: July 2023

Abstract

In this work, the planar optical waveguide on the Er3+-doped germanate glass was fabricated by the oxygen ion implantation with the energy of 6.0 MeV and the fluence of 5×1014 ions/cm2. The waveguide was characterized with the techniques of the m-line setup and the near-field pattern. The waveguide shows guided-mode propagation at a wavelength of 632.8 nm. The formation theory of the planar waveguide was discussed through simulating the energy loss distribution and analyzing the reconstructed refractive index profile. The ion implantation results in around 4.8 µm thickness of higher refractive index layer to guide light as a waveguide core in the Er3+-doped germanate glass, which could be used for applications in future integrated optical systems.
Pilot-scale field studies on activated microbial remediation of petroleum contaminated soil
Authors: Sun Wu-Juan , Li Qian , Luo Bo-Yun , Sun Rui , Ke Cong-Yu , Wang Si-Chang , Zhang Qun-Zheng , Zhang Xun-Li 
Published: July 2023

Abstract

A simple and cost-effective microbial remediation process has been developed for the treatment of petroleum contaminated soil by adding microbial activators to active the native microorganisms for enhancing the degradation of petroleum hydrocarbon. The microbial activator is formulated to provide nitrogen sources, phosphorus sources, trace elements, growth factors, biosurfactants, and soil pH regulators. The field trials, involving two 500 m3 oily soil samples with initial oil content of 5.01% and 2.15%, respectively, show that the petroleum hydrocarbon content can be reduced to 0.41% and 0.02%, respectively, in 50 days, reaching the national standard of cultivated land category II. The treatment period is significantly shorter than the commonly used composting and bioaugmentation methods. The remediation effect of microbial activator on oily soil was investigated through the germination experiment of rye seeds. The results showed that the activator itself could not only activate the functional microorganisms in the soil, but also reduce the biological toxicity of oily soil. After 40 days of treatment, the germination rate of rye seeds increased from 20–90%, indicating that the microbial activator could be effectively used for rapid in-situ remediation of oil contaminated soil.
Robust 3D Object Tracking with X-Triplet Markers: A Machine Learning-Based Approach
Authors: Shen Hongbin , Meng Cai , Deng Xinliang , Chen Diansheng 
Published: July 2023

Abstract
In this paper, we propose an efficient and robust X-Triplet detection method based on the support vector machine (SVM) and an adjacent matrix for locating and tracking objects through stereo vision with minimal feature points. The X-Triplet, denoted as Tri-X, is a composite marker consisting of three sequential X-corners. The definition and types of Tri-X markers are initially presented. Further, a fast and robust X-corner detector based on the block search strategy and SVM is proposed for extracting X-corner candidates along with their sub-pixel locations and orientations. The X-corner adjacent matrix (XAM) is then constructed using the orientation angle error to describe the possibility that any X-corner pair can form a valid edge vector. The Tri-X candidates are extracted efficiently from the XAM. Once the Tri-X markers are detected in binocular images, their 6D pose information can be recovered through stereo matching and triangulation technique. When multiple targets are involved simultaneously, different Tri-X markers can be utilized to identify different objects. Experimental results demonstrate the superiority of our method in terms of both accuracy and efficiency for X-corner and Tri-X marker detection, surpassing state-of-the-art approaches. Notably, our method achieves exceptional localization precision with a remarkable position error below 0.1mm and an orientation error below 1 degree. Additionally, our method exhibits great potential for utilization in user-defined specific tracking tasks, offering flexibility and adaptability to various tracking requirements.
A comparison of demographic, medical, social, and lifestyle behaviour correlates between cancer and non-cancer populations: a secondary analysis of the English Longitudinal Study of Aging cohort
Authors: De-Alker Elisha Cerys , Forbes Cynthia C. 
Published: July 2023

Abstract
Purpose
This secondary analysis of the English Longitudinal Study of Aging (ELSA) dataset aims to explore differences in sociodemographic, medical, psychosocial, and behavioural characteristics between cancer and non-cancer populations.
Methods
Data was collected in waves via computer-assisted interviewing, self-led questionnaires, and nurse-led physical measurements. Datasets were arranged according to variables of interest. IBM SPSS Statistics v27.0 software was used to perform parallel cross-sectional analyses. Chi-squares determined differences in categorical variables and Analyses of Variance (ANOVAs) determined differences in continuous variables.
Results
Cancer groups were more likely to report poor or fair general health than those without cancer (p < .001 in Waves 2, 6, 9 and COVID Wave 2; p = .016 in COVID Wave 1). They were also more likely to report often being troubled by pain (Wave 2 p = .037, Wave 6 p = .036, Wave 9 p = .006) and a difficulty with one or more activities of daily living (ADLs) and mobility (p < .001 in Waves 2, 6 and 9). In Waves 6, 9 and COVID Wave 2, cancer groups were less likely to report being current smokers (p < .001) and more likely to report being ex-smokers having smoked regularly in the past (p < .001). Cancer groups reported less frequent engagement in mild, moderate or vigorous physical activity in Wave 2 (p < .001, p = .005, p = .008) and Wave 9 (p = .003, p < .001, p < .001). Those with cancer were more likely to experience depression (p = .026) in Wave 6.
Conclusion
These findings indicate pain management may be a useful therapeutic aim in combination with targeted physical activity advice and psychosocial interventions for cancer populations.
Design Optimization of Marine Propeller using Elitist Particle Swarm Intelligence
Authors: Khan Fahad Ali , Shoukat Nadeem , Shah Ajmal , Bhatti Matloob Hussain , Hashmi Abrar , Muhammad Usama , Tariq Muhammad Atiq Ur Rehman , Jan Syed Mansoor 
Published: July 2023

Abstract
Marine transportation is still the primary source of global transportation. The propeller, which is a critical componentof the propulsion system, must be designed with multiple constraints and objectives to satisfy the need. Recent studies propose that utilizing an improved optimization algorithm and computational analysis would explore better designs than conventionalmethods. In the present study, Elitist Particle Swarm Optimization (EPSO) technique is implemented to optimize the design ofa marine propeller. Potsdam’s Conventional Propeller VP 1304 is used as a benchmark design case. Reynold’s Averaged NavierStokes equation based Computational Fluid Dynamics (CFD) along with Vortex Lattice Method (VLM) and Fluid StructureInteraction (FSI) model is used for computational analysis. The results obtained in this study are validated against the previously published experimental data. An optimized propeller design is proposed based on the Elitist Particle Swarm Optimization technique.It is observed that the proposed design shows improved open water performance for lower advance coefficient (J) valuesbased on the given constraints. It’s also observed that open water efficiency is improved by 7 percent for J=0.6 compared tothe original design. The one-way Fluid Structure Interaction analysis shows that the proposed design is structurally stable underopen water test conditions