bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral Blok Fascial Pekto Interkosta Sebagai Ajuvan pada Operasi CABG
Authors: Herlambang Dedi , Hadinata Yudi 
Published: February 2023

Latar Belakang: Regional blok sebagai ajuvan dalam operasi jantung mulai banyak digunakan sebagai terapi tambahan untuk mengurangi nyeri selama periode intraoperatif dan pascaoperasi, diantaranya blok Pekto Interkosta Fasial (PIF). Pembedahan jantung identik dengan penggunaan opioid dosis tinggi. Pada laporan kasus ini, kami melaporkan penggunaan blok PIF pada pasien dewasa yang menjalani operasi CABG.Kasus: Laki-laki, usia 58tahun, diagnosa penyakit jantung koroner, menjalani operasi CABG. Pembahasan: Kami lakukan ajuvan blok PIF pada anestesi umum dengan anestesi lokal bupivakain 0,25%+ epinephrine 1:200.000 dengan volume 20ml sisi kanan dan 20ml sisi kiri. Hemodinamik terpantau stabil tanpa penambahan opioid selama periode operasi.Kesimpulan: Penggunaan teknik PIF Blok efektif menurunkan penggunaan opioid dan menjamin pengelolaan nyeri yang adekuat pada operasi CABG. Blok ini dapat dipergunakan sebagai salah satu alternatif teknik analgesia untuk pasien sternotomi maupun kasus lain yang melibatkan rongga dada bagian depan.
Entrepreneurial Attitudes, Intentions and Motivations among University Students in the National Capital Region
Authors: Mangada Miguel E. 
Published: February 2023

Utilizing the descriptive-comparative and descriptive-correlational research designs, the researcher employed a questionnaire as the principal tool in gathering data from 518 college students enrolled in the business program of the different universities in the National Capital Region (NCR) during the school year 2014-2015 through a convenience sampling.
The findings of the study revealed that majority of the university college students belonged to the 20 years old group, were females, born in the middle sibling order, had parents who reached college, and had an average monthly income ranging from P30,000 and above, and whose families were self-employed, and had previous entrepreneurial family experience.
The study indicated that the respondents had a positive attitude towards entrepreneurship. The respondents were found to have high entrepreneurial intentions. For the push factors that motivate respondents to become

entrepreneurs, the respondents were much affected by the different push factors, while the pull factors were not very important to them. .
The study also found that the exogenous factors hindering the respondents’ intention of becoming entrepreneurs will be serious problem to the respondents if they enter the world of entrepreneurship and these will bother them a lot especially upon starting a business, and so do the endogenous factors.
Furthermore, the study found the following: a) that there was a significant difference between gender and entrepreneurial attitudes as manifested by the p- value of 0.000 which is less than 0.05 or 5%; b)that there was a significant relationship between the entrepreneurial attitudes and intention of the respondents as manifested by the p-value which is -0.169 and verbally interpreted as very low correlation and with the p-value = 0.000 which is less than 0.05 or 5%, thus, led the researcher to reject the null hypothesis (Ho); c) that there was no significant relationship between entrepreneurial intentions and motivational factors as manifested by the p-value of 0.505 and 0.611 which were higher than 0.05 or 5 percent; d) that in terms of pull factors, the entrepreneurial intentions do not affect the motivational factors or the other way around; e) that the push factors or the motivational factors do not affect the entrepreneurial intentions of the respondents. This means that even if how good are the entrepreneurial intentions, there is a possibility that motivational factors will not be good and vice versa; f) in terms of exogenous factors, the entrepreneurial intention and hindering factors do not significantly relate with one another as manifested by the r- value of 0.075 and also p-value

of 0.870 which is greater than 0.05 or 5 percent; and g) when endogenous factors were considered, a significant relationship exists between the entrepreneurial intention and hindering factors.
Impaired calcium handling mechanisms in atrial trabeculae of diabetic patients
Authors: Jones Timothy L. M. , Kaur Sarbjot , Kang Nicholas , Ruygrok Peter N. , Ward Marie‐Louise 
Published: February 2023

AbstractThe aim of this study was to investigate cardiomyocyte Ca2+ handling and contractile function in freshly excised human atrial tissue from diabetic and non‐diabetic patients undergoing routine surgery. Multicellular trabeculae (283 ± 20 μm in diameter) were dissected from the endocardial surface of freshly obtained right atrial appendage samples from consenting surgical patients. Trabeculae were mounted in a force transducer at optimal length, electrically stimulated to contract, and loaded with fura‐2/AM for intracellular Ca2+ measurements. The response to stimulation frequencies encompassing the physiological range was recorded at 37°C. Myofilament Ca2+ sensitivity was assessed from phase plots and high potassium contractures of force against [Ca2+]i. Trabeculae from diabetic patients (n = 12) had increased diastolic (resting) [Ca2+]i (p = 0.03) and reduced Ca2+ transient amplitude (p = 0.04) when compared to non‐diabetic patients (n = 11), with no difference in the Ca2+ transient time course. Diastolic stress was increased (p = 0.008) in trabeculae from diabetic patients, and peak developed stress decreased (p ≤ 0.001), which were not accounted for by reduction in the cardiomyocyte, or contractile protein, content of trabeculae. Trabeculae from diabetic patients also displayed diminished myofilament Ca2+ sensitivity (p = 0.018) compared to non‐diabetic patients. Our data provides evidence of impaired calcium handling during excitation‐contraction coupling with resulting contractile dysfunction in atrial tissue from patients with type 2 diabetes in comparison to the non‐diabetic. This highlights the importance of targeting cardiomyocyte Ca2+ homeostasis in developing more effective treatment options for diabetic heart disease in the future.
Symmetry and nonsymmetry of minimal action sign-changing solutions for the Choquard system
Authors: Chen Jianqing , Zhang Qian 
Published: February 2023

AbstractIn this article, we consider the following Choquard system inRNN≥1{{\mathbb{R}}}^{N}N\ge 1−Δu+u=2pp+q(Iα∗∣v∣q)∣u∣p−2u,−Δv+v=2qp+q(Iα∗∣u∣p)∣v∣q−2v,u(x)→0,v(x)→0as∣x∣→∞,\left\{\begin{array}{l}-\Delta u+u=\frac{2p}{p+q}({I}_{\alpha }\ast | v{| }^{q})| u{| }^{p-2}u,\\ -\Delta v+v=\frac{2q}{p+q}({I}_{\alpha }\ast | u{| }^{p})| v{| }^{q-2}v,\\ u\left(x)\to 0,v\left(x)\to 0\hspace{1em}\hspace{0.1em}\text{as}\hspace{0.1em}\hspace{0.33em}| x| \to \infty ,\end{array}\right.whereN+αN<p,q<N+αN−2\frac{N+\alpha }{N}\lt p,q\lt \frac{N+\alpha }{N-2},2∗α{2}_{\ast }^{\alpha }denotesN+αN−2\frac{N+\alpha }{N-2}ifN≥3N\ge 3and2∗α≔∞{2}_{\ast }^{\alpha }:= \inftyifN=1,2N=1,2,Iα{I}_{\alpha }is a Riesz potential. By analyzing the asymptotic behavior of Riesz potential energy, we prove that minimal action sign-changing solutions have an odd symmetry with respect to the a hyperplane whenα\alphais either close to 0 or close toNN. Our results can be regarded as a generalization of the results by Ruiz et al.
Visual inspection intelligent robot technology for large infusion industry
Authors: Liang Qilang , Luo Bangshun 
Published: February 2023

Abstract
The application of intelligent technology has realized the transformation of people’s production and lifestyle, and it has also promoted the development of the field of medicine. At present, the intensity of intelligence in the field of medicine is increasing. By using its cash methods and techniques combined with the mechanical field, this article proposes to use visual inspection technology to understand the fusion of the medical field and the mechanical field. It is helpful to analyze and solve objective problems such as low efficiency in current infusion and insufficient rigidity of large infusion plastic bottles. Drawing on the principles and laws of deep learning algorithms and neural networks, the technical research of intelligent robots for visual inspection is carried out to realize the intelligence of infusion robots. In the research accuracy of detection, the detection rate of standard particles higher than 85 µM has reached almost 100%, and the rate of 50 µM standard particles is lower and unstable. The detection effect of the control light bulb control was different, and the detection rate was between 50 and 80%, which was obviously worse than the detection robot effect. Therefore, the current research on the technology of intelligent robots is very important.
Bond of corroded reinforcement in strain resilient cementitious composites
Authors: Tastani Sousana 
Published: February 2023

Abstract
In corroded steel anchorages, radial pressures generated by corrosion and bond are balanced by hoop tension provided by the concrete cover. As the concrete has negligible tension strain capacity, in the absence of confinement, anchorage failure occurs by cover splitting and consequent bond deterioration. This paper presents an experimental study of short reinforcement anchorages embedded in a strain resilient cementitious composite matrix, which were preconditioned under simulated corrosion before mechanical loading. The experiment was meant to assess the restraining effect of randomly dispersed plastic fibers on the build-up of expansive rust, by measuring the degree of rebar corrosion that led to cracking of the concrete cover, and the consequent improvements in residual anchorage capacity, by measuring the mechanical response to four-point loading. A total of eighteen short beams were tested with variables being the anchorage length extending into the shear span of the beams as well as the matrix (with and without fibers). Comparisons among artificially corroded and non-corroded coupons demonstrate the favorable effect a strain resilient matrix has in delaying metal consumption as a consequence of the fibers’ restrain against crack initiation/widening; their mechanical testing reveals even increase of local bond strength for corrosion level less than 10%.
Numerical simulation of fluid flow mixing in flow-focusing microfluidic devices
Authors: Aghaei Halimeh , Solaimany Nazar Ali Reza 
Published: February 2023

Abstract
A numerical simulation through computational fluid dynamics is presented on the fluid flow mixing in a flow-focusing microfluidic device with three inlet channels confluence angles of 45, 67.5, and 90°. The effect of various parameters such as aspect ratio (0.5, 1, and 1.5), mixing channel length (1–4 mm), and Reynolds number (1–20) on the mixing efficiency, and the pressure drop are evaluated. The results demonstrate that the increase in mixing efficiency results from an increase in the Reynolds number and aspect ratio for all the angles. In addition, an increase in the pressure drop due to an increase in the Reynolds number and a decrease in the aspect ratio is observed. A longer length of the mixing channel indicates a higher mixing efficiency. The mixing efficiency is more suitable at an angle of 45° among the applied angles in terms of the operational and geometric parameters due to an increase in the contact surface of the flows at the inlet channels junction since the mixing index range is between 0.54 and 1 by varying the mentioned parameters.
Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions
Authors: Wadey Geoffrey P. , Doherty Katrina E. , Sandoval Arturo León , Leadbeater Nicholas E. 
Published: February 2023

Abstract
Novel acyl pyrazoles and acyl triazoles have been prepared by means of the oxidative amidation of aldehydes in the presence of the requisite azole. Yields range from modest to good in both cases, and some limitations of the substrate scope have been discovered. Acyl pyrazoles were prepared by treatment of a mixture of aldehyde and pyrazole with an oxoammonium salt bearing the nitrate anion. In the case of acyl triazoles, the oxidative functionalization was performed using sodium persulfate as a terminal oxidant in the presence of a catalytic quantity of a nitroxide.
Contextual Specificity of (Un)Healthy Food/Drink Intake in Everyday Life: A Study Based on Episodic Memories
Authors: Laguna-Camacho Antonio 
Published: February 2023

Abstract
Identifying the contexts of episodes of (un)healthy food/drink intake could inform strategies for eating more healthily. This study assessed memories of recent episodes of healthy and unhealthy eating from adults in Mexico. For each (un)healthy eating episode participants recalled place, time of day, people present and food/drink intake. Categories were formed for the contextual features and foods/drinks that were reported, then the relative frequency of each category was tested between healthy and unhealthy eating episodes. Overall, there was a large set of categories of (un)healthy food/drink choices, and there were more healthy eating episodes with family at home and unhealthy eating episodes with friends out of home. However, as expected, a more specific context as well as food/drink intake was identified for each sort of recalled (un)healthy eating episode of the day. Additionally, eating out of home, later in the day and with people present were features related to higher estimated energy content across (un)healthy eating episodes. These findings support the assessment of self-reported memories of recent eating episodes to generate evidence that contribute to contexts that support healthy eating habits.
Abstinence-Induced Nicotine Seeking Relays on a Persistent Hypoglutamatergic State within the Amygdalo-Striatal Neurocircuitry
Authors: Domi Ana , Domi Esi , Lagstrom Oona , Gobbo Francesco , Jerlhag Elisabet , Adermark Louise 
Published: February 2023

AbstractNicotine robustly sustains smoking behavior by acting as a primary reinforcer and by enhancing the incentive salience of the nicotine-associated stimuli. The motivational effects produced by environmental cues associated with nicotine delivery can progressively manifest during abstinence resulting in reinstatement of nicotine seeking. However, how the activity in reward neuronal circuits is transformed during abstinence-induced nicotine seeking is not yet fully understood. In here we used a contingent nicotine and saline control self-administration model to disentangle the contribution of cue-elicited seeking responding for nicotine after drug abstinence in male Wistar rats. Usingex vivoelectrophysiological recordings and a network analysis approach, we defined temporal and brain-region specific amygdalo-striatal glutamatergic alterations that occur during nicotine abstinence. The results from this study provide critical evidence indicating a persistent hypoglutamatergic state within the amygdalo-striatal neurocircuitry over protracted nicotine abstinence. During abstinence-induced nicotine seeking, electrophysiological recordings showed progressive neuroadaptations in dorsal and ventral striatum already at 14-d abstinence while neuroadaptations in subregions of the amygdala emerged only after 28-d abstinence. The observed neuroadaptations pointed to a brain network involving the amygdala and the dorsolateral striatum (DLS) to be implied in cue-induced reinstatement of nicotine seeking. Together these data suggest long-lasting neuroadaptations that might reflect neuroplastic changes responsible to abstinence-induced nicotine craving. Neurophysiological transformations were detected within a time window that allows therapeutic intervention advancing clinical development of preventive strategies in nicotine addiction.
The essential role of forkhead box P4 (FOXP4) in thyroid cancer: a study related to The Cancer Genome Atlas and experimental data
Authors: Zhou Tian , Zhao Dai-wei , Ma Ning , Zhu Xue-ying , Chen Xing-hong , Luo Xue , Chen Song , Gao Qing-jun 
Published: February 2023

Objective
Thyroid cancer (THCA) is the most common endocrine cancer in the world. Although most patients with THCA have a good prognosis, the prognosis of those with THCA who have an extra-glandular invasion, vascular invasion, and distant metastasis is poor. Therefore, it is very important to find potential biomarkers that can effectively predict the prognosis and progression of highly aggressive THCAs. It has been identified that forkhead box P4 (FOXP4) may be a new biomarker for the proliferation and prognosis for tumor diagnosis. However, the expression and function of FOXP4 in THCA remain to be determined.

Methods
In the present study, the function of FOXP4 in cells was investigated through the comprehensive analysis of data in The Cancer Genome Atlas and combined with experiments including immunohistochemistry (IHC), colony formation, Cell Counting Kit-8 assay, wound scratch healing, and transwell invasion assay.

Results
In the present study, relevant bioinformatic data showed that FOXP4 was highly expressed in THCA, which was consistent with the results of the IHC and cell experiments. Meanwhile, 10 FOXP4-related hub genes were identified as potential diagnostic genes for THCA. It was found in further experiments that FOXP4 was located in the nucleus of THCA cells, and the expression of FOXP4 in the nucleus was higher than that in the cytoplasm. FOXP4 knockdown inhibited in vitro proliferation of the THCA cells, whereas overexpression promoted the proliferation and migration of THCA cells. Furthermore, deficiency of FOXP4 induced cell-cycle arrest.

Conclusion
FOXP4 might be a potential target for diagnosing and treating THCA.
Testosterone therapy increases the anticoagulant potential in men with opioid-induced hypogonadism: a randomized, placebo-controlled study
Authors: Bøgehave Mette , Glintborg Dorte , Gram Jørgen Brodersen , Bladbjerg Else-Marie , Andersen Marianne Skovsager , Sidelmann Johannes Jakobsen 
Published: February 2023

Introduction
Hypogonadism is prevalent during opioid treatment, and low testosterone concentrations are associated with cardiovascular disease. The effect of testosterone replacement therapy (TRT) on the coagulation system in men with hypogonadism is not clarified. We investigate the effects of TRT on the tissue factor (TF) and contact activation pathways of coagulation in opioid-treated men.

Materials and methods
This was a double-blinded, placebo-controlled study in 37 men with total testosterone < 12 nmol/L randomized to 24 weeks of testosterone injections (n = 17) or placebo (n = 20). Variables of the coagulation system were analysed at baseline and after 24 weeks. Measurements included the TF pathway (endogenous thrombin potential (ETP) and peak thrombin), the contact activation pathway (endogenous kallikrein potential (EKP) and peak kallikrein), coagulation factors (FVII, FX, prothrombin, and FXII), and inhibitors (tissue factor pathway inhibitor (TFPI), protein C, protein S, antithrombin, and C1 esterase inhibitor (C1inh)). Between-group differences at 24 weeks were determined with analysis of covariance. Within-group changes in TRT and placebo were analysed with paired t-test.

Results
Between-group differences at 24 weeks were observed for ETP (P = 0.036), FVII (P = 0.044), FX (P = 0.015), prothrombin (P = 0.003), protein C (P = 0.004), and protein S (P = 0.038). Within the TRT group, ETP, peak thrombin, FVII, FX, prothrombin, TFPI, protein C, FXII, and C1inh decreased and protein S increased (all P < 0.05). Within the placebo group, coagulation outcomes were unchanged.

Conclusion
TRT affects the coagulation system in an anticoagulant direction through suppressed TF pathway in men with opioid-induced hypogonadism.
Epistemología del sur y Movimientos Sociales de Abya Yala en Re-existencia territorial
Authors: DUQUINO ROJAS LUIS GABRIEL 
Published: February 2023

El presente artículo tiene como objetivo presentar, en el corpus de la epistemología del sur, revisada desde la perspectiva de los pueblos del sur global, una estructura válida para el estudio y entendimiento de los movimientos sociales en re-existencia territorial de Abya Yala. La metodología esta basada en la propia estructura de la epistemología del sur, en las herramientas constituidas por la hermenéutica diatópica, la dialógica crítica y la construcción solidaria del conocimiento. Como resultado se presenta el discurso desde los pueblos originarios en re-existencia como ejercicio de vencimiento de la producción de las ausencias y superación de la epistemología de la ceguera del pensamiento moderno colonial. En conclusión, se evidencia que, aun cuando los principales enunciados de la epistemología del sur corresponden al mundo académico, este se alimentó principalmente de los saberes-sentires-pensares de los pueblos en re-existencia del Sur Global, y que se hace urgente devolverles esa voz central en los procesos de revalidación y valoración de sus luchas.
Hacia un método de aprendizaje en la ciudad: The city as a lab idea
Authors: Sarmiento-Díaz Javier Francisco 
Published: February 2023

Este artículo presenta los resultados de una investigación doctoral que emplea el escenario de la ciudad para avanzar en la construcción de un método para la enseñanza del espacio urbano en los talleres de urbanismo, en Arquitectura. A través de la estrategia de recorridos urbanos en la ciudad de Bogotá, planteados pedagógicamente, se busca que los estudiantes avancen en la comprensión e interpretación del espacio urbano. Esta investigación es de enfoque cualitativo, desde parte de un diseño de investigación acción pedagógica (IAP) y usa los instrumentos de entrevista, cuestionario abierto y observación participante para triangular la información recolectada. El análisis se centró en determinadas características asociadas con el método de aprendizaje, evidenciadas a través de los recorridos, así como en la comprensión del espacio urbano. El escenario posibilitó a los estudiantes avanzar hacia la comprensión e interpretación de un espacio geográfico en el que se ubica la vida social y las diferentes dimensiones que conforman el espacio urbano y lo dotan de significados a través del tiempo: así, la ciudad se entiende como un sistema complejo que representa un potencial de aprendizaje para el urbanismo en la enseñanza universitaria.