bluuebunny/crossref_metadata_2025_split huggingface dataset:
No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies
Authors: Pushpamithran Giggil , Skoglund Camilla , Olsson Fanny , Méndez-Aranda Melissa , Schön Thomas , Segelmark Mårten , Stendahl Olle , Gilman Robert H. , Blomgran Robert 
Published: June 2023

AbstractHelminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb have long been ranked as the number one single infectious agent claiming the most lives. The only licensed vaccine for TB (BCG) offers highly variable protection against TB, and almost no protection against transmission of Mtb. In recent few years the identification of naturally occurring antibodies in humans that are protective during Mtb infection has reignited the interest in adaptive humoral immunity against TB and its possible implementation in novel TB vaccine design. The effects of helminth/TB coinfection on the humoral response against Mtb during active pulmonary TB are however still unclear, and specifically the effect by globally prevalent helminth species such as Ascaris lumbricoides, Strongyloides stercoralis, Ancylostoma duodenale, Trichuris trichiura. Plasma samples from smear positive TB patients were used to measure both total and Mtb-specific antibody responses in a Peruvian endemic setting where these helminths are dominating. Mtb-specific antibodies were detected by a novel approach coating ELISA-plates with a Mtb cell-membrane fraction (CDC1551) that contains a broad range of Mtb surface proteins. Compared to controls without helminths or TB, helminth/TB coinfected patients had high levels of Mtb-specific IgG (including an IgG1 and IgG2 subclass response) and IgM, which were similarly increased in TB patients without helminth infection. These data, indicate that helminth/TB coinfected have a sustained humoral response against Mtb at the level of active TB only. More studies on the species-specific impact of helminths on the adaptive humoral response against Mtb using a larger sample size, and in relation to TB disease severity, are needed.
Economical revenue maximization in mobile edge caching and blockchain enabled space-air-ground integrated networks
Authors: Du Jianbo , Lv Jiaju , Lu Guangyue 
Published: June 2023

AbstractIn this paper, we study an edge caching and blockchain enabled space-air-ground integrated networking (SAGIN) network, where a low-earth-orbit (LEO) satellite serves as the content provider, and multiple edge caching enabled unmanned aerial vehicles (UAVs) will cache some contents to provide user equipments (UEs) with satisfactory content access services together with the satellite. Moreover, there’s a blockchain system that is deployed on UAVs, to provide the network with trust mechanism without requiring a centralized authority. From the standpoint of the operator, we intend to maximize the long-term averaged economical revenue by providing UEs with satisfactory and secure content access services. To achieve this purpose, we will jointly optimize the content placement of each UAV, content replacement when each UAV is full, the access control of each UE, and the blockchain deployment strategy about each UAV. the concept of queues in Lyapunov optimization is utilized to represent the backlog of edge equipment, ensuring the stability of virtual queues on UAVs and satellites, while satisfying the caching capacity constraints for content caching and blockchain deployment. Due to the tight coupling of optimization in each time slot and the variables within each time slot, our problem, which involves stochastic optimization and binary integer programming, is challenging to solve. To address this issue, we initially employ Lyapunov optimization theory to transform and decouple the problem into individual time-slot optimization problems. Subsequently, we utilize an effective heuristic algorithm called the fireworks algorithm to solve these individual optimization problems. However, the original fireworks algorithm cannot be directly applied to our problem due to its binary characteristics and inter-coupling constraints. Therefore, we have redesigned the explosion and mutation operations to adapt them to our specific problem. Simulation results demonstrate that our proposed algorithm outperforms other baseline algorithms.
Normal thyroid stimulating hormone is associated with all-cause mortality in patients with acute myocardial infarction after percutaneous coronary intervention
Authors: Ni Wei-cheng , Kong Shu-ting , Lin Ken , Huang Yu-heng , Li Jun-feng , Shi San-ling , Lu Yu-cheng , Cheng Ling , Chen Chang-xi , Zhou Hao 
Published: June 2023

Abstract
Background
Circulating thyroid-stimulating hormone (TSH) levels within the normal reference range can affect the cardiovascular system. The present study investigated the prognostic value of normal TSH levels in patients presenting with acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI).

Methods
Between January 2013 and July 2019, 1240 patients with AMI and normal thyroid function were enrolled and classified according to TSH tertile. The trial endpoint was all-cause mortality. The integrated discrimination index (IDI) and the net reclassification index (NRI) were used to assess the combined predictive values of the TSH levels and the Global Registry of Acute Coronary Events (GRACE) scores.

Results
After a median 44.25-month follow-up, 195 individuals died. Even after covariate adjustment by multivariate Cox regression (HR: 1.56; 95% CI 1.08–2.25; P = 0.017), the patients in the third TSH tertile were at the highest risk of all-cause mortality. A subgroup analysis revealed significant interactions between the TSH levels and the GRACE scores (high risk vs. low/medium risk) (P = 0.019). The addition of the TSH levels to the GRACE scores substantially improved the prediction of all-cause mortality, especially for high-risk patients (NRI = 0.239; IDI = 0.044; C-statistic value range 0.649–0.691; all significant).

Conclusions
The third TSH tertile is associated with a higher incidence of all-cause mortality than the first TSH tertile in high-risk patients presenting with AMI after PCI.
Examining correlates of aggression and mediating effect of psychological distress between exposure to media violence and aggression in lebanese adults
Authors: Chabbouh Alfred , Hallit Souheil , Farah Nour , Youssef Christina , Hankache Abdo , Fekih-Romdhane Feten , Bitar Zeinab , Obeid Sahar 
Published: June 2023

Abstract
Background
Violent media is the most consumed type of media in Lebanon. Many studies have linked exposure to media violence to increased aggression and psychological distress. As Lebanon is going through socio-political turmoil, we aimed to [1] explore the correlates of aggression (i.e., sociodemographic factors, BMI, loneliness, social competence, and psychological distress) in a sample of Lebanese adults from the general population, and [2] to examine the mediating effect of psychological distress in the association between exposure to media violence and aggression in this sample.

Methodology
Adults were recruited through online convenience sampling. We employed scales to assess content-based media exposure (C-ME), aggression (BPAQ-SF), psychological distress (DASS-8), loneliness (JGLS), and perceived social competence (PSCS).

Results
Exposure to media violence was associated with all four aggression subtypes (verbal, physical, hostility, and anger). Psychological distress partially mediated all these associations; higher exposure to media violence was significantly associated with more psychological distress, which was significantly associated with higher levels of all types of aggression. Moreover, higher exposure to media violence was significantly associated with higher levels of all types of aggression.

Conclusion
In the sociopolitical context of Lebanon, violent media could be considered a public hazard. Psychological distress likely potentiates the association between exposure to violent media and aggression. Future research should focus on determining what components of psychological distress underpin this mediation.
The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
Authors: Fodder Katherine , de Silva Rohan , Warner Thomas T. , Bettencourt Conceição 
Published: June 2023

AbstractNeurodegenerative diseases encompass a heterogeneous group of conditions characterised by the progressive degeneration of the structure and function of the central or peripheral nervous systems. The pathogenic mechanisms underlying these diseases are not fully understood. However, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in Alzheimer’s disease (AD), inclusions of hyperphosphorylated microtubule-binding tau in AD and other tauopathies, or inclusions containing α-synuclein in Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Various pathogenic mechanisms are thought to contribute to disease, and an increasing number of studies implicate dysfunction of oligodendrocytes (the myelin producing cells of the central nervous system) and myelin loss. Aberrant DNA methylation, the most widely studied epigenetic modification, has been associated with many neurodegenerative diseases, including AD, PD, DLB and MSA, and recent findings highlight aberrant DNA methylation in oligodendrocyte/myelin-related genes. Here we briefly review the evidence showing that changes to oligodendrocytes and myelin are key in neurodegeneration, and explore the relevance of DNA methylation in oligodendrocyte (dys)function. As DNA methylation is reversible, elucidating its involvement in pathogenic mechanisms of neurodegenerative diseases and in dysfunction of specific cell-types such as oligodendrocytes may bring opportunities for therapeutic interventions for these diseases.
Nano-fluorescent quantum dots as substrates for determination of ribavirin in pharmaceuticals and human plasma as well as monitoring of its kinetic interaction with salmon sperm DNA
Authors: Abdel Hakiem Ahmed Faried , Boushra John M. , Noureldeen Deena A. M. , Lashien Adel S. , Attia Tamer Z. 
Published: June 2023

AbstractRibavirin (RIB) was successfully determined by fluorescence spectroscopy upon its quenching to environment friendly phosphorus and nitrogen co-doped carbon quantum dots (PNQDs). Different analytical parameters affecting the fluorescence spectra have been optimized and validated in accordance to the ICH guidelines. The proposed method has provided an efficient tracing of the interaction between RIB molecules and the synthesized QDs in an acidic medium (off-mode). The RIB molecules have shown excellent sensitivity by quenching of the emission band at 401 nm upon excitation at 245 nm throughout a linear range of 0.06–10.00 µg/mL with detection and quantitation limits down to 14.00 and 40.00 ng/mL, respectively. The quenching mode was proven to be static in raw samples and samples extracted of spiked plasma for quenching rate constants of 1.30 × 1012 L M−1 S−1 and 1.73 × 1012 L M−1 S−1, respectively. The proposed method has been successfully applied for determination of RIB in the commercial capsules and spiked human plasma samples with good recovery percentages in between 102.00 and 103.00%. Interestingly, these carbon dots have been utilized as nano-fluorescent platforms for assessment of the binding interaction kinetics between the RIB molecules and salmon sperm DNA (ssDNA). This has been implemented through peeling off the RIB molecules from surface of the PNQDs upon successive addition of the ssDNA and hence fluorescence restoration (turning on). Consequently, this provides a successful monitoring of its antimicrobial potency. It was evidenced a strong binding interaction with a binding constant of 2.38 × 104 mol−1/L. Significantly, this could open doors for an extended application for on-site monitoring of RIB as well as its interactions with biomolecules and microorganisms.
Robotic‐assisted total knee arthroplasty is not associated with increased risk of postoperative deep vein thrombosis
Authors: Itou Junya , Kuwashima Umito , Itoh Masafumi , Okazaki Ken 
Published: June 2023

AbstractPurposeProlongation of operation time due to registration and pin insertion has been reported with robotic‐assisted total knee arthroplasty (RATKA), and there has been concern about an increase in the postoperative incidence of deep vein thrombosis (DVT). In this study, we compared the incidence of DVT after RATKA with that after conventional manual TKA (mTKA).MethodsThis consecutive retrospective series included 141 knees that underwent primary TKA using the Journey II system. The CORI robot was used. There were 60 RATKAs and 81 mTKAs. Doppler ultrasound was performed in all patients on postoperative day 7 to determine whether DVT was present.ResultsThe operation time was longer in the RATKA cohort (99.5 min vs 78.0 min, p < 0.001). The overall incidence of DTV was 43.9% (62/141 knees), all of which were asymptomatic. There was no significant difference in incidence of DVT between RATKA and mTKA (50.0% vs 39.5%, p = 0.23). Use of the robot did not affect the incidence of DVT following TKA (odds ratio 1.02, 95% confidence interval 0.40–2.60; p = 0.96).ConclusionThe incidence of DVT was not significantly different between RA‐TKA and mTKA. Multiple logistic regression indicated that RATKA is not associated with increased risk of postoperative DVT.Level of evidenceIV.
A randomised controlled feasibility trial of an early years language development intervention: results of the ‘outcomes of Talking Together evaluation and results’ (oTTer) project
Authors: Nielsen Dea , d’Apice Katrina , Cheung Rachael W. , Bryant Maria , Heald Rebecca , Storr Chloe , Tracey Louise , Rashid Rukhsana , Dickerson Josie , Bowyer-Crane Claudine 
Published: June 2023

Abstract
Background
Early language difficulties are associated with poor school readiness and can impact lifelong attainment. The quality of the early home language environment is linked to language outcomes. However, few home-based language interventions have sufficient evidence of effectiveness in improving preschool children’s language abilities. This study reports the first stage in the evaluation of a theory-based programme, Talking Together (developed and delivered by BHT Early Education and Training) given over 6 weeks to families in the home setting. We aimed to test the feasibility and acceptability of delivering Talking Together in the Better Start Bradford community prior to a definitive trial, using a two-armed randomised controlled feasibility study.

Methods
Families from a single site within the Better Start Bradford reach area were randomly allocated (1:1) to the Talking Together intervention or a wait list control group. Child language and parent-level outcome measures were administered before randomisation (baseline), pre-intervention (pre-test), 2 months post-intervention start (post-test), and 6 months post-intervention start (follow-up). Routine monitoring data from families and practitioners were also collected for eligibility, consent, protocol adherence, and attrition rates. Descriptive statistics on the feasibility and reliability of potential outcome measures were analysed alongside qualitative feedback on trial design acceptability. Pre-defined progression-to-trial criteria using a traffic light system were assessed using routine monitoring data.

Results
Two-hundred and twenty-two families were assessed for eligibility; of these, 164 were eligible. A total of 102 families consented and were randomised (intervention: 52, waitlist control: 50); 68% of families completed outcome measures at 6-month follow-up. Recruitment (eligibility and consent) reached ‘green’ progression criteria; however, adherence reached ‘amber’ and attrition reached ‘red’ criteria. Child- and parent-level data were successfully measured, and the Oxford-CDI was identified as a suitable primary outcome measure for a definitive trial. Qualitative data not only indicated that the procedures were largely acceptable to practitioners and families but also identified areas for improvement in adherence and attrition rates.

Conclusions
Referral rates indicate that Talking Together is a much-needed service and was positively received by the community. A full trial is feasible with adaptations to improve adherence and reduce attrition.

Trial registration
ISRCTN registry ISRCTN13251954. Retrospectively registered 21 February 2019
A fatal case of fulminant group: a streptococcal infection in a neonate
Authors: Satoh Fumiko , Irie Wataru , Sasaki Chizuko , Ochiai Eriko , Kondo Maho 
Published: June 2023

Abstract
Background
Fulminant hemolytic streptococcal infection is a condition of sudden onset and rapidly progressing septic shock caused by Streptococcus pyogenes. It causes beta (complete) hemolysis. Although type A Streptococcus occurs more frequently, all streptococci that cause beta-hemolysis are eligible as causes. This report describes a rare autopsy case of fulminant group A streptococcal infection in a neonate.

Case presentation
A 16-day-old girl, 3300 g, born by spontaneous delivery at 41 weeks 1 day, experienced a 1-day history of low-grade fever, malaise, and a few hours of cyanosis and anuria, prompting her parents to bring her to the hospital. Her eldest brother, who lived with her, had been infected with Streptococcus approximately one month earlier, and had been treated with ten days of antibiotics. The infant died three hours after presentation. Autopsy findings indicated her to be 52 cm in length, weighing 3585 g, with medium build and normal nutrition. Her lungs were slightly oligemic with decreased volumes. The liver and kidneys were mildly enlarged. The spleen was markedly enlarged. The adrenal glands showed diffuse cortical hemorrhage (Fig. 1). There was some thymic atrophy (thymus weight 7.4 g, < 1 SD below the mean). Histopathological findings included chronic and neutrophilic infiltration of the tonsils and multiple septic emboli containing cocci in the lungs. Perivascular inflammatory cell infiltrates were observed in the lungs, myocardium, kidneys, adrenal glands, brain, meninges, and liver, with micro-necrotic changes in the kidneys and liver. Fibrin thrombi were observed in multiple renal glomeruli. Hemophagocytosis by macrophages was observed in the spleen, liver, lymph nodes, bone marrow, and adrenal glands. Immunostaining showed positive results for group A Streptococcus antibody in the tonsils, with bacterial masses. Blood cultures were positive for group A Streptococcus pyogenes.

Conclusions
Because of the lower respiratory tract infection and suspected sibling transmission, in addition to the adrenal hemorrhages, a diagnosis of fulminant sepsis with group A Streptococcus pyogenes with associated Waterhouse–Friderichsen syndrome was made.
Interleukin 8 in children with obstructive sleep apnea before and after adenotonsillectomy
Authors: Abdelmonem Nourhan I. , Tabbakh Mohammed T. El , Farid Alaa M. , Rashwan Mohamed S. 
Published: June 2023

Abstract
Objective
To assess serum interleukin 8 (IL-8) levels after adenotonsillectomy in children with symptoms suggestive for OSA.

Study design
Prospective interventional study.

Settings
The study was carried out on 30 children with OSA attending ENT clinic of Suez Canal University Hospital.

Methods
Including, children with sleep-related chronic intermittent hypoxia (CIH) and OSA symptoms performed an elective adenotonsillectomy, and aged (3–12 years). Excluding, children with acute tonsillitis, cardiorespiratory, craniofacial, or diseases affecting IL-8 level as cystic fibrosis, COVID-19 patients, and hepatitis C, taking drugs affecting IL-8 level as benzodiazepines or glutamine supplementation. Children were subjected to full history, clinical examination and laboratory investigations. Nocturnal pulse oximetry (ChoiceMMed) was performed (48–72 h preoperative and 3–4 weeks postoperative) used to determine the number of 4% dips in saturation from baseline, and the nadir saturation (nSAT). IL-8 was measured 1 month pre-operative and 1 month post-operative by flow cytometry using the Human Inflammatory Cytometric Bead Array kit.

Results
The mean preoperative IL-8 (237.55 p/ml) and oxygen desaturation index (7.77%)cwere statistically significantly higher than mean postoperative IL-8 (207.98 p/ml) and oxygen desaturation index (2.90). The mean pre-operative SpO2 is 98.27 ranged (96.00–100.0%), while the mean postoperative SpO2 is 98.77 ranged (97.00–100.0%), with no statistically significant difference between them (p = 0.069). Preoperative IL-8 (p/ml), postoperative IL-8 (p/ml), and preoperative SpO2 (%) were found to be negatively correlated with IL-8 change.

Conclusion
IL-8 level significantly decreased after adenotonsillectomy in children with symptoms suggestive for OSA.
A Plea for the Insane by Lionel Weatherly
Authors: Hilton Claire 
Published: June 2023

SUMMARYIn A Plea for the Insane (1918), Lionel Weatherly outlined the inadequacies of the Lunacy Act 1890 and of asylum care in England and Wales, and proposed solutions and ways to bring about improvements. It took courage to persist, but Weatherly was undeterred by controversy or criticism. This article reflects on his book and its context and timing at the end of the First World War, and considers whether we may be inspired to confront current healthcare crises with the same sort of passion and fervour as he did.
Improving the Quality of the Delivery of Nutritional Care Among Children Undergoing Treatment for Cancer in a Low- and Middle-Income Country
Authors: Damasco-Avila Erika , Zelaya Sagastizado Stephany , Carrillo María , Blanco Jessica , Fu Ligia , Espinoza Darrell , Ladas Elena J. 
Published: June 2023

PURPOSE International twinning programs have been well-established between institutions in childhood cancer and have led to pediatric cancer units in low- and middle-income countries (LMICs) adopting multidisciplinary forms of care. To advance nutritional care in LMICs, the International Initiative for Pediatrics and Nutrition (IIPAN) provided the structural framework and personnel for the delivery of nutritional care. We describe the impact of a newly established nutrition program on the delivery of nutritional care and nutrition-related clinical outcomes in children and adolescents undergoing treatment for cancer in Nicaragua and Honduras. METHODS A prospective cohort (N = 126) collected clinical data over a 2-year period. Collection of IIPAN's nutritional services received during treatment and clinical data were abstracted from medical charts and registered in Research Electronic Data Capture (REDCap) database. Chi-square, ANOVA, and generalized linear mixed models were used; P < .05 was considered statistically significant. RESULTS Nutritional assessments led to a higher number of patients receiving recommended standard of care. Children classified as underweight during treatment presented higher number of infections and toxicities, length of hospital stay, and days of treatment delays during treatment. Overall, from the start to end of treatment, 32.5% of patients improved nutritional status, 35.7% maintained it, and 17.5% worsened. On the basis of metrics, the cost per consultation was less than 4.80 US dollars (USD; Honduras) and 1.60 USD (Nicaragua). CONCLUSION Integration and equitable access of the nutritional care process for all patients needs to be recognized as a component of the basic management in pediatric oncology care. IIPAN's nutritional program demonstrates that nutritional care is economical and feasible in a limited resource setting.