bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anemia hemolítica en una adolescente de 16 años como manifestación de infección por Mycobacterium tuberculosis
Authors: Osorio Milena Villamil , Gualteros Sonia María Restrepo , Tafurth Nasly Katerin , Camacho Germán 
Published: February 2023

INTRODUCCIÓN Y OBJETIVOS En la anemia hemolítica autoinmune hay producción de anticuerpos contra los glóbulos rojos y, por ende, destrucción de los mismos. La tuberculosis es una infección bacteriana crónica de distribución mundial que puede afectar diferentes órganos y sistemas. Se ha considerado que la anemia normocítica, normocrómica es el hallazgo hematológico más frecuente en paciente con tuberculosis y que la anemia hemolítica es muy rara. En un país endémico como el nuestro se debe buscar de manera activa la tuberculosis; nuestro objetivo es mostrar la presentación atípica de una infección bastante típica. INFORME DEL CASONiña de 16 años de edad, con cuadro clínico de 1 mes de síntomas constitucionales, 2 semanas de coluria e ictericia en las escleróticas, remitida para estudio de síndrome anémico con hemoglobina de 5,7 g/dL. Los análisis de laboratorio mostraron anemia hemolítica y las imágenes de tórax, cavitación pulmonar apical izquierda; inicialmente se pensó en neumonía necrosante. Se inició tratamiento de la anemia con un corticoide sistémico. Como cumplía los criterios tuberculínico, radiológico y clínico para el diagnóstico de tuberculosis se inició el tratamiento tetraconjugado.La reacción en cadena de la polimerasa para tuberculosis fue positiva en el líquido de lavado broncoalveolar. La paciente presentó mejoría clínica con el tratamiento y se resolvieron los síntomas constitucionales y la anemia.CONCLUSIONESLa tuberculosis infecta a un tercio de la población mundial y en 1993 fue declarada emergencia sanitaria global por la Organización Mundial de la Salud. Esta enfermedad se ha asociado a vasculitis del sistema nervioso central, arteritis y trombocitopenia inmune, pero encontramos muy pocos casos en la literatura de pacientes tuberculosos con anemia hemolítica, la mayoría de ellos adultos. Se han propuesto varios mecanismos para explicar su ocurrencia: en modelos animales se ha documentado que los productos de M. tuberculosis producen anemia, pancitopenia y mielofibrosis; en humanos se considera que la amplia distribución de los bacilos y sus productos puede llevar a proliferación del tejido reticuloendotelial con trastornos hematológicos por alteración inmune; sin embargo, los descensos marcados de la hemoglobina son raros lo que nos motivó a reportar este caso.Recalcamos la importancia de tener sospecha diagnóstica para tuberculosis aun cuando la presentación inicial no es la típica.
Serología en hepatitis virales
Authors: Jaramillo Aristizábal María Clara , García Rendón María Valentina , Restrepo Gutiérrez Juan Carlos 
Published: February 2023

Cuando ocurre infección por el virus de hepatitis A (VHA), virus de hepatitits B (VHB), virus de hepatitis C (VHC) virus de hepatitis D o virus de hepatitis E (VHE) el cuadro clínico y bioquímico es similar, por lo que se hace necesario recurrir a pruebas de laboratorio diferentes a las de función hepática para identificar con certeza el agente etiológico; dentro de estas se encuentran: la serología, que permite detectar antígenos virales o anticuerpos contra estos y las pruebas moleculares que permiten detectar el genoma viral. Para diagnosticar la existencia de una infección actual por alguno de estos virus basta con la realización de pruebas serológicas, excepto en el caso del infección por VHC para la que es necesario realizar detección del genoma viral. Las pruebas moleculares son de gran utilidad para el seguimiento y la toma de decisiones terapéuticas en los pacientes con infección crónica por VHB o VHC.
Una visión sucinta de la enseñanza de la medicina a lo largo de la historia: I. Desde el Antiguo Imperio Egipcio hasta el siglo XVII
Authors: Díaz Hernández Diana Patricia 
Published: February 2023

Para llegar a una comprensión sobre cómo se ha enseñado la medicina a través de los tiempos, es necesario apoyarse en los historiadores que han abordado la evolución de la medicina y, a partir de ello, indagar sobre cuál era la actitud del médico en su posición de docente y cómo era la apropiación del conocimiento de la época por parte de los estudiantes. En este artículo se presentará un recorrido a través de de las diferentes épocas que impactaron en los avances y retrocesos de la enseñanza de la medicina; desde el antiguo imperio egipcio (3000-2500 A.de.C) y su gran legado en los papiros continuando con los grandes progresos de la medicina griega para terminar con el oscurantismo en la edad media.
Anwendung der Verwaltungsschale in der Prozessindustrie
Authors: Höper Björn , Schüller Andreas , Tauchnitz Thomas 
Published: February 2023

Das Konzept der Verwaltungsschale (VWS) wird seit dem Jahr 2018 als eine technische Implementierung zur Ermöglichung von interoperablen digitalen Zwillingen entwickelt. Die Verwaltungsschale erlaubt die strukturierte Sammlung und Verwaltung aller digitalen Informationen eines Assets. Im Bereich der Fabrikautomation wird die VWS in ersten Use Cases eingesetzt. Die NAMUR hat im November 2021 den Arbeitskreis AK 1.4 „Verwaltungsschale“ gegründet, um die Anwendung in der Prozessindustrie zu prüfen und zu fördern. Dieser Beitrag stellt die ersten beiden erarbeiteten Use Cases für die Anwendung der VWS beim Engineering einer PLT-Stelle und bei einem Geräteaustausch dar. Anhand dieser Beispiele werden Anforderungen und Möglichkeiten dafür entwickelt, wie die in den Use Cases beschriebenen Arbeitsschritte durch Verwaltungsschalen und Teilmodelle abgebildet werden können.
THE CLINICAL AND LABORATORY EVALUATION OF THE EFFECTIVENESS OF THE APPLICATION OF PHARMACOLOGICAL COMPOSITION BASED OF THE COMPONENTS MAKING AN EFFECT ON THE CONNECTIVE TISSUE EXCHANGE DURING COMPLEXED PERIODONTITIS TREATMENT OF THE PATIENTS WITH DYSPLASIA OF THE CONNECTIVE TISSUE
Authors: Nagaeva Marina , Griroriev Sergey , Kolpakov Viktor 
Published: February 2023

Periodontal Inflammatory diseases of the patients with dysplasia of the connective tissue (DCT) characterized by the torpidity; the decreased reaction to the topical treatment. To maintain the effectiveness of the treatment of the destructive-inflammatory diseases of the periodontitis of the people with DCT, medicinal composition was invented. The medical composition consists of the components involved in the biosynthesis of the connective tissue, having high level of the transmucosal activity, anti-inflammatory and reparative effect.
The purpose of the study is an evaluation of the effectiveness of the local application of the pharmacological composition with the reparative effect consisting of the components making an effect on the connective tissue exchange during complexed periodontitis treatment of the patients with dysplasia of the connective tissue.
Methodology. In the research, 56 adults were involved (37,9 ± 2,2 years old). The participants are male and female, having undifferentiated forms of DCT and moderately severe chronic periodontitis diagnosis. The patients were divided into two groups: 1st group – got the standardized treatment of the chronic periodontitis according to the clinical recommendations n = 27); 2nd group – got the standardized treatment of the chronic periodontitis supplemented with the application of the invented pharmacological composition after the surgical stage for the 14-day period, n = 29. An original and dynamic evaluation of the clinical and laboratory indicators (the index evaluation of the periodontitis and hygiene of the oral cavity; the index of hemomicrocirculation in the periodontal tissues; oxyproline content in the oral fluid) was conducted after 7, 14, 30 and 180 days.
The results: The effectiveness was confirmed with the complexed dynamic comparative monitoring of the several clinical and laboratory indicators for the 6-month period. The statistically important differences were revealed in the index evaluation (PMA, PBI, PI); the index of the local hemomicrocirculation (Q am, the pulsation index); the content of the oxyproline in the oral fluid after 30 and 180-days periods.
Conclusion. The invented pharmacological composition with the reparative effect consisting of the components making an effect on the connective tissue exchange, has shown the effectiveness while the complexed treatment of the periodontitis of the patients with undifferentiated dysplasia of the connective tissue.
STUDY OF THE MINERALIZATION OF HARD TISSUES OF THE TEETH AFFECTED BY RADIATION CARIES USING THE METHOD OF RAMAN FLUORESCENT DIAGNOSIS
Authors: Nurieva Natal'ya , Belaykov German 
Published: February 2023

Subject. Mineralization of hard tissues of teeth affected by radiation caries in patients after radiation therapy of malignant neoplasms.
Objectives. To develop a digital method for diagnosing radiation caries based on Raman fluorescence technology.
Methodology. The study was conducted at the Department of Orthopedic Dentistry and Orthodontics of South Ural State Medical University. The study was conducted on two groups of people (cohorts) comparable in sex and age, who voluntarily agreed to take part in it. The main group consisted of 20 people (patients with radiation caries), the comparison group – 20 people (without radiation caries). The main research method was the study of Raman fluorescence of tooth areas using the «InSpectr» hardware-software complex with diagnostic sensitivity according to the integral concentration of aerobic-anaerobic microbial suspension up to 109 KOE/ml. A study was made of teeth in the pathological area in patients of the main group, and in the intact area in patients of the comparison group.
Results. Raman fluorescent diagnostics of the intact tooth surface and the surface with a pathological focus made it possible to clearly see the difference in mineralization in digitized indicators. So, for example, according to the indicators of patients with damage to the teeth by radiation caries, it can be concluded that the indicators of mineralization in the focus affected by radiation caries ( y = 172 ± 0.04, x = 963 cm-1) are lower than those of the intact area (y = 1174 ± 0.071, x = 963 cm-1)
Conclusion. The method of Raman fluorescence diagnostics can be used in the diagnosis of radiation caries, since there is a potential difference between the healthy and the affected areas of the hard tissues of the tooth. On the basis of the study, the author recommends using the «InSpectr» hardware-software complex for diagnosing radiation caries.
CLINICAL AND RADIOLOGICAL ANALYSIS OF PERIODONTAL STRUCTURES IN ANATOMICAL AND FUNCTIONAL DISORDERS OF THE MUCOGINGIVAL COMPLEX
Authors: Kirienkova Ekaterina , Tokmakova Svetlana , Chudova Larisa , Gurevich Yuri , Levchenko Olga , Gaidarova Tatiana , Zhukova Elena 
Published: February 2023

Subject. Anatomical and functional disorders of the mucogingival complex.
Objectives. To evaluate microcirculatory, clinical and radiological changes in periodontal tissues in various variants of mucogingival complex disorders.
Methodology. The study was conducted at the Department of Therapeutic Dentistry of ASMU. In the course of the study, 80 patients (49 women, 31 men) aged 18 to 35 years were examined with a ratio of dentition close to orthognathic bite in the presence of maximum occlusion. Three groups were formed depending on the anatomical and functional state of the mucogingival complex. In the clinical part of the study, an objective assessment of the condition of periodontal tissues was carried out on the basis of a dental examination with a comprehensive analysis of the periodontal status. The X-ray examination included the analysis and description of cone-beam computed tomograms for patients of clinical groups. To assess microcirculation in periodontal tissues, the method of ultrasonic Dopplerography with functional probe breakdown was used.
Results. In the studied groups, the level of oral hygiene was characterized as good, and the indicators of hygiene indices did not differ significantly, periodontal indices indicated the absence or minimal degree of inflammation in periodontal tissues. Carrying out a functional tension test made it possible to divide patients into subgroups according to the type of reaction: normal, compensated, subcompensated, decompensated. According to the results of the study of CBCT in the comparison group, pathological changes in the bone tissue of the alveolar process of the studied areas were not recorded, in patients of the first clinical group, in most cases (80.2%), pathological changes in the bone tissue of the alveolar process were not observed, in the rest (19.8%), a low level of alveolar bone was noted. In patients of the second clinical group, the phenomena of osteoporosis and an increase in the distance from the dental enamel-cement border to the edge of the outer cortical plate were recorded.
Conclusions. X-ray changes in bone tissue most often corresponded to the already existing clinical symptoms of periodontal tissue damage against the background of mucogingival pathology. The predictors of prenosological diagnosis in anatomical and functional disorders of the mucogingival complex were changes in microcirculation indicators.
IMPROVING THE PROTOCOL FOR THE OPERATION OF ONE-STAGE DENTAL IMPLANTATION OF PATIENTS WITH TOOTH LOSS
Authors: Diachkova Ekaterina , Tarasenko Svetlana , Sudiev Sergey , Ivanov Sergey , Kuznetsov Alexei , Atef Sokar , Bekasov Il'a 
Published: February 2023

Subject. The technique of immediate dental implantation, analysis of its results and treatment protocol improvement.
Aim. To increase the effectiveness of the rehabilitation of patients with chronic periodontitis and traumatic tooth fracture (with indications for extraction) based on the improvement of the protocol for the operation of one-stage dental implantation.
Methodology. In the period from 2020 to 2022, on the basis of the Department of Oral Surgery and Maxillofacial surgery department of the RUDN University and Sechenov University, the immediate dental implantation was performed in 20 patients with a diagnosis of Chronic periodontitis and tooth fracture (K.04.5, S02.5 ICD-10) (with indications for their removal ) with the installation of 20 dental implants: Osstem Implant (South Korea) – 10 units (50%), IRIS (Russia) – 10 units (50%). In all cases, the gingival cuff shapers were installed simultaneously. If necessary, osteoplastic materials and gingival autografts were used. The installation of dental implants was carried out with a depth of 2–3 mm, depending on the jaw section, and was displaced orally with a minimum distance to the vestibular cortical plate of 1.5 mm.
Results. At the end of our study, no complications were identified, 100% integration of implants was obtained, as well as their 100% survival and stability, both according to CBCT data, and according to the results of a follow-up examination 12 months after permanent prosthetics restorations.
Conclusion. According to the results of our study, immediate implantation made it possible to carry out a full-fledged rehabilitation of patients if tooth extraction was necessary, to reduce the overall treatment time in the absence of complications in the postoperative period.
ASSOCIATIONS OF POLYMORPHISM OF THE VITAMIN D RECEPTOR (VDR) GENE AND GINGIVAL RECESSION IN MIXED DENTITION
Authors: Akisheva Aigul , Valeeva Ildaria , Mamaeva Elena , Akhtereeva Alsu , Valeeva Elena , Akhmetov Ildus 
Published: February 2023

Subject of study. The development of new approaches to early diagnosis and identification of predisposition to the formation of gingival recession in children is an urgent task of modern dentistry. It is known that vitamin D plays an important role, affecting, among other things, the immune system and calcium-phosphorus homeostasis through the vitamin D receptor (VDR). In connection with the above, a promising direction is the study of polymorphisms of the vitamin D receptor gene to determine markers of gingival recession in a removable bite.
Purpose: to study the relationship of the polymorphic marker Bsm I (rs1544410 T/C) of the VDR gene with a predisposition to gingival recession in children in a removable bite living in the Republic of Tatarstan.
Methodology. We examined 81 children with gingival recession in a removable bite (8 ± 1 years old) living in the Republic of Tatarstan. DNA was isolated from buccal epithelial cells. Genotyping of the rs1544410 polymorphism of the VDR gene was performed using a real-time PCR.
Results. A positive relationship was found for the rs1544410 T allele of the VDR gene with class II gingival recession in a removable bite according to Miller's classification (p = 0.021, r = 0.258), and recession depth (p = 0.029, r = 0.24).
Conclusions. 1. A positive correlation was found between the risk allele T of the BsmI (rs1544410) polymorphism of the VDR gene and clinical manifestations of gingival recession in a removable bite in a sample of the population of the Republic of Tatarstan. 2. The distribution of alleles and genotypes of the BsmI (rs1544410) polymorphism of the VDR gene did not differ between the observation and control groups.
MAKNA SABAR BAGI TERAPIS (Studi Fenomenologis di Yayasan Bina Autis Mandiri Palembang)
Authors: Darmawan Amita , Lukmawati Lukmawati 
Published: February 2023

Autis adalah anak yang memiliki hambatan dalam proses sosial, komunikasi, perilaku dan bahasa. Setiap anak autis memiliki kondisi yang berbeda-beda, untuk kondisi autis berat memiliki perilaku tantrum yang berlebihan, yaitu sering menunjukkan perilaku negatif pada orang-orang di sekitarnya terutama pada para terapis.Oleh sebab itu, dalam mendidik anak autis dibutuhkan kesabaran yang ekstra.Sebagaimana fenomena yang peneliti temukan di yayasan Bina Autis Mandiri Palembang (BAM) menunjukkan bahwa beberapa terapis sering mendapatkan perlakuan negatif dari anak-anak autis yang diterapinya.Adapun beberapa bentuk perilaku negatif yaitu meninju, memukul dan mancakar terapis.Untuk itu penelitian ini bertujuan untuk memahami makna sabar bagi masing-masing para terapis.Metode yang digunakan dalam penelitian ini adalah kualitatif-fenomenologis.Fenomenologi menekankan pengalaman subjektifitas atau pandangan berfikir yang menekankan pada pengalaman-pengalaman subjektif manusia dan interpretasi-interpretasi dunia subyek. Peneliti menggunakan empat subyek yaitu terapis yang bekerja di yayasanBina Autis Mandiri Palembang.Metode pengumpulan data menggunakan wawancara mendalam, observasi dandokumentasi.Hasil penelitian menunjukkan bahwa subjek memaknai sabar: (1) menerima semua kondisi, muncul perilau sabar berawal dari rasa sayang dan ketulusan serta tetap tenang dalam menghadapi perilaku anak autis. (2) menerima dengan ikhlas apapun ujian yang Allah berikan dan selalu berprasangka baik (husnudzon) terhadap semua masalah. (3) dapat menahan diri dan emosi atas perilaku negatif dari anak-anak autis, misalnya saat mereka refleks memukul ataupun melakukan hal negatif lainnya yang dapat menyakiti fisik terapis, untuk tidak membalas perlakuan tersebut. (4) dapat mengatur emosi dengan cara berusaha menekan egonya.
MENYIKAPI DORONGAN SEKSUAL DI MASA REMAJA (Tinjauan Hadist Psikologi)
Authors: Hariyanto Toto 
Published: February 2023

Hal yang dapat dilakukan secara nyata untuk menangulangiperilaku seks bebas di kalangan remaja adalah melalui pendidikan . Adapun tujuan pendidikan Agama pada remaja yaitu untuk memberikan informasi yang benar mengenai perilaku dan kehidupan seks yang baik sesuai dengan norma dan nilai-nilai yang berlaku di masyarakat. Rasulullah saw telah memberikan tuntunan yang tepat menyikapi dorongan seksual di masa remaja. Sehingga perubahan yang terjadi dalam diri remaja yang memiliki dampak dalam proses tumbuh kembang kehidupan remaja dapat diarahkan sesuai dengan aturan syariat dan akhlak.
HUBUNGAN ANTARA KOHESIVITAS DENGAN INTENSI PERILAKU AGRESI PADA SUPORTER SEPAK BOLA
Authors: Safitri Anfa , Andrianto Sonny 
Published: February 2023

This research aims to find out there is whether or not a corelation between cohesivity with intention of aggression behavior on football supporters. Early allegations put forward in the present study is there is a positive corelation between cohesiveness with Intention of aggression behaviour. The subjects in this research is 50 student Supporters of football Slemania, everything is made up of men. The scale is a scale used Intention of aggression behaviour laid out based on intention behavior researchers according to the aspect Fishbein dan Ajzen (1975) \the General behavior of aggression according to classification Buss & Perry (Nashori & Diana, 2007), as for measuring cohesiveness using aspects of forsyth (1999).Methods of data analysis conducted in the present study uses statistical analysis using correlation spearmant correlation coefficients of r = 0,265 show with p = 0, 014 (p<0,05). Correlation analysis can be taken to mean that there is a very significant positive relationship between cohesiveness with Intention of aggression behaviour on football supporters. That means the higher the level of cohesiveness owned by supporters then it will be the higher Intention of aggression behaviour. Conversely, the lower the level of cohesiveness that it will be the lower clubs too Intention of aggression behaviour.
EFEKTIVITAS SALAT TAUBAT DALAM MENINGKATKAN KETENANGAN HATI
Authors: Rusdi Ahmad 
Published: February 2023

The purpose of this study is examine the prayers of repentance effect on sobriety. Respondents of this study are 49 Students. This research was conducted by using a simple experiment. Researchers have explained how the prayers of repentance to be done during one week. sobriety was measured before and after one week. sobriety consists of two aspects, composure (al-suku>n) and conviction (al-yaqi>n). After prayers of repentance for one week, sobriety on respondents increased significantly (Sig 0,00) both aspects, al-suku>n (Sig 0,00) and al-yaqi>n (Sig 0,036). Some details of the results of this study showed unique results. This study concluded that multidimensional prayers of repentance will increase sobriety periodically.
LATAR BELAKANG KECEMASAN ANAK PRA SEKOLAH KASUS A (IM) SISWA TAMAN KANAK-KANAK AR-RAHMAH PALEMBANG
Authors: Tamisa Aslam 
Published: February 2023

he reseach aims to find out the background of pre-school children's anxiety cases A kindergarten student Ar-Rahmah Palembang. The problem of being discussed is how background anxiety pre-school children. This reseach was a qualitative case study. Data collection techniques using observation, interviews, documentation, and analysis using the concept of "fish bone" is looking for the cause of anxiety. Comparing data observations with interviews, compares the results interview delivered in public with what is said in private, and comparing sources perspective with expert opinions psychology. Results of research conducted on a pre-school children Kindergarten students obtained the information came from families where both parents work in a private company from morning until afternoon, had an attitude and behavior that makes the subject is always full of excessive fear. Subjects behave like screaming, aloof, evasive and not able to be with his friends, cold hands or palms are always wet, often to the bathroom with no apparent reason. His parents, especially the father always angry rebuke and erratically toward the subject so that the subject is always crying for attention excess of teachers in schools. Conclusion experienced subjects is excessive anxiety, need attention and affection from their parents, as well as applying parenting attached to embed principles such as compassion positive touch, sensitivity to the needs of children, and to have time with the child.