bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of alternative cannabis product use and poly-use with subsequent illicit drug use initiation during adolescence
Authors: Braymiller Jessica L. , Riehm Kira E. , Meier Madeline , Krueger Evan A. , Unger Jennifer B. , Barrington-Trimis Jessica L. , Cho Junhan , Lanza H. Isabella , Madden Danielle R. , Kechter Afton , Leventhal Adam M. 
Published: March 2023

Abstract
Rationale
Specific cannabis products may differentially increase risk of initiating non-cannabis illicit drug use during adolescence.

Objective
To determine whether ever- and poly-use of smoked, vaporized, edible, concentrate, or blunt cannabis products are associated with subsequent initiation of non-cannabis illicit drug use.

Methods
High school students from Los Angeles completed in-classroom surveys. The analytic sample (N = 2163; 53.9% female; 43.5% Hispanic/Latino; baseline M age = 17.1 years) included students who reported never using illicit drugs at baseline (spring, 11th grade) and provided data at follow-up (fall and spring, 12th grade). Logistic regression models assessed associations between use of smoked, vaporized, edible, concentrate, and blunt cannabis at baseline (yes/no for each product) and any non-cannabis illicit drug use initiation—including cocaine, methamphetamine, psychedelics, ecstasy, heroin, prescription opioids, or benzodiazepines—at follow-up.

Results
Among those who never used non-cannabis illicit drugs at baseline, ever cannabis use varied by cannabis product (smoked = 25.8%, edible = 17.5%, vaporized = 8.4%, concentrates = 3.9%, and blunts = 18.2%) and patterns of use (single product use = 8.2% and poly-product use = 21.8%). After adjustment for baseline covariates, odds of illicit drug use at follow-up were largest for baseline ever users of concentrates (aOR [95% CI] = 5.74[3.16–10.43]), followed by vaporized (aOR [95% CI] = 3.11 [2.41–4.01]), edibles (aOR [95% CI] = 3.43 [2.32–5.08]), blunts (aOR [95% CI] = 2.66[1.60–4.41]), and smoked (aOR [95% CI] = 2.57 [1.64–4.02]) cannabis. Ever use of a single product (aOR [95% CI] = 2.34 [1.26–4.34]) or 2 + products (aOR [95% CI] = 3.82 [2.73–5.35]) were also associated with greater odds of illicit drug initiation.

Conclusions
For each of five different cannabis products, cannabis use was associated with greater odds of subsequent illicit drug use initiation, especially for cannabis concentrate and poly-product use.
Abiotic factors and endophytes co-regulate flavone and terpenoid glycoside metabolism in Glycyrrhiza uralensis
Authors: Liu Zidi , Ma Yunyang , Lv Xuelian , Li Nannan , Li Xiaohan , Xing Jianmin , Li Chun , Hu Bing 
Published: March 2023

Abstract
Recently, endorhizospheric microbiota is realized to be able to promote the secondary metabolism in medicinal plants, but the detailed metabolic regulation metabolisms and whether the promotion is influenced by environmental factors are unclear yet. Here, the major flavonoids and endophytic bacterial communities in various Glycyrrhiza uralensis Fisch. roots collected from seven distinct places in northwest China, as well as the edaphic conditions, were characterized and analyzed. It was found that the soil moisture and temperature might modulate the secondary metabolism in G. uralensis roots partially through some endophytes. One rationally isolated endophyte Rhizobium rhizolycopersici GUH21 was proved to promote the accumulation of isoliquiritin and glycyrrhizic acid significantly in roots of the potted G. uralensis under the relatively high-level watering and low temperature. Furthermore, we did the comparative transcriptome analysis of G. uralensis seedling roots in different treatments to investigate the detailed mechanisms of the environment-endophyte-plant interactions and found that the low temperature went hand in hand with the high-level watering to activate the aglycone biosynthesis in G. uralensis, while GUH21 and the high-level watering cooperatively promoted the in planta glucosyl unit production. Our study is of significance for the development of methods to rationally promote the medicinal plant quality.

Key points
• Soil temperature and moisture related to isoliquiritin contents in Glycyrrhiza uralensis Fisch.
• Soil temperature and moisture related to the hosts’ endophytic bacterial community structures.
• The causal relation among abiotic factors—endophytes—host was proved through the pot experiment.
Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
Authors: Botticelli Andrea , Cirillo Alessio , Pomati Giulia , Cortesi Enrico , Rossi Ernesto , Schinzari Giovanni , Tortora Giampaolo , Tomao Silverio , Fiscon Giulia , Farina Lorenzo , Scagnoli Simone , Pisegna Simona , Ciurluini Fabio , Chiavassa Antonella , Amirhassankhani Sasan , Ceccarelli Fulvia , Conti Fabrizio , Di Filippo Alessandra , Zizzari Ilaria Grazia , Napoletano Chiara , Rughetti Aurelia , Nuti Marianna , Mezi Silvia , Marchetti Paolo 
Published: March 2023

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have particular, immune-related adverse events (irAEs), as a consequence of interfering with self-tolerance mechanisms. The incidence of irAEs varies depending on ICI class, administered dose and treatment schedule. The aim of this study was to define a baseline (T0) immune profile (IP) predictive of irAE development.MethodsA prospective, multicenter study evaluating the immune profile (IP) of 79 patients with advanced cancer and treated with anti-programmed cell death protein 1 (anti-PD-1) drugs as a first- or second-line setting was performed. The results were then correlated with irAEs onset. The IP was studied by means of multiplex assay, evaluating circulating concentration of 12 cytokines, 5 chemokines, 13 soluble immune checkpoints and 3 adhesion molecules. Indoleamine 2, 3-dioxygenase (IDO) activity was measured through a modified liquid chromatography–tandem mass spectrometry using the high-performance liquid chromatography-mass spectrometry (HPLC–MS/MS) method. A connectivity heatmap was obtained by calculating Spearman correlation coefficients. Two different networks of connectivity were constructed, based on the toxicity profile.ResultsToxicity was predominantly of low/moderate grade. High-grade irAEs were relatively rare, while cumulative toxicity was high (35%). Positive and statistically significant correlations between the cumulative toxicity and IP10 and IL8, sLAG3, sPD-L2, sHVEM, sCD137, sCD27 and sICAM-1 serum concentration were found. Moreover, patients who experienced irAEs had a markedly different connectivity pattern, characterized by disruption of most of the paired connections between cytokines, chemokines and connections of sCD137, sCD27 and sCD28, while sPDL-2 pair-wise connectivity values seemed to be intensified. Network connectivity analysis identified a total of 187 statistically significant interactions in patients without toxicity and a total of 126 statistically significant interactions in patients with toxicity. Ninety-eight interactions were common to both networks, while 29 were specifically observed in patients who experienced toxicity.ConclusionsA particular, common pattern of immune dysregulation was defined in patients developing irAEs. This immune serological profile, if confirmed in a larger patient population, could lead to the design of a personalized therapeutic strategy in order to prevent, monitor and treat irAEs at an early stage.
Adaptive Image Processing: First Order PDE Constraint Regularizers and a Bilevel Training Scheme
Authors: Davoli Elisa , Fonseca Irene , Liu Pan 
Published: March 2023

AbstractA bilevel training scheme is used to introduce a novel class of regularizers, providing a unified approach to standard regularizers$$TGV^2$$TGV2and$$NsTGV^2$$NsTGV2. Optimal parameters and regularizers are identified, and the existence of a solution for any given set of training imaging data is proved by$$\Gamma $$Γ-convergence under a conditional uniform bound on the trace constant of the operators and a finite-null-space condition. Some first examples and numerical results are given.
Prevalence of neural tube defects among pregnant women in Addis Ababa: a community-based study using prenatal ultrasound examination
Authors: Tirsit Abenezer , Zewdneh Daniel , Yigeremu Mahlet , Legese Aga , Moen Bente E. , Lie Rolv T. , Lund-Johansen Morten , Mahesparan Rupavathana 
Published: March 2023

Abstract
Purpose
The primary aim of this study was to estimate the prevalence of NTDs at ultrasound examination in communities of Addis Ababa and secondarily to provide a description of the dysmorphology of the NTD cases.

Methods
We enrolled 958 pregnant women from 20 randomly selected health centers in Addis Ababa during the period from October 1, 2018, to April 30, 2019. Of these 958 women, 891 had an ultrasound examination after enrollment, with a special focus on NTDs. We estimated the prevalence of NTDs and compared it with previously reported hospital-based birth prevalence estimates from Addis Ababa.

Results
Among 891 women, 13 had twin pregnancies. We identified 15 NTD cases among 904 fetuses, corresponding to an ultrasound-based prevalence of 166 per 10,000 (95% CI: 100–274). There were no NTD cases among the 26 twins. Eleven had spina bifida (122 per 10,000, 95% CI: 67–219). Among the 11 fetuses with spina bifida, three had a cervical and one had a thoracolumbar defect while the anatomical site for 7 was not registered. Seven of the 11 spina bifida defects had skin covering, while two of the cervical lesions were uncovered.

Conclusion
We report a high prevalence of NTDs among pregnancies in communities of Addis Ababa based on screening by ultrasound. The prevalence was higher than in previous hospital-based studies in Addis, and the prevalence of spina bifida was particularly high.
Maximum Northern Hemisphere warming rates before and after 1880 during the Common Era
Authors: Seip Knut Lehre , Wang Hui 
Published: March 2023

AbstractWe find that maximal decadal Northern Hemisphere warming increases as rapidly before as after the industrial revolution (0.86 °C decade−1 before 1880 and 0.60–0.68 °C decade−1 after 1880). However, whereas the number of decadal periods with large increase and decrease rates were about equal before 1880 (267 vs. 273), after 1880 there are more periods with high increase rates (35) than with high decrease rates (9). The same patterns hold for bi-decadal rates. However, for time windows greater than about 20 years, the slope in global warming with time becomes greater after 1880. After 1971, there is only one short 11 year period with negative slopes. This reflects the higher frequency of positive slopes during the industrial period caused by the contribution of greenhouse gases (GHG). Maximum temperature changes for detrended series were associated with the beginning and end of extreme warm or cold sub periods. They occurred throughout all of the Common Era. Because the detrended temperature series showed sign of a pacemaker mechanism (regular cycle periods) we suggest that ocean variabilities were a dominating mechanism for multidecadal temperature variability during the Common Era.
Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
Authors: Fischer Igor , Chaudhry Shafqat Rasul , Hänggi Daniel , Muhammad Sajjad 
Published: March 2023

Abstract
Post-aSAH sequela is characterized by the onset of life-threatening complications along with the upregulated underlying inflammation. Cerebral vasospasm (CVS) is one of the most frequent complication after aSAH, which contributes majorly to delayed cerebral ischemia and poor clinical outcome. The objective of this study was to identify the clusters of serum biomarkers that are associated with cerebral vasospasm (CVS) after suffering from aneurysmal subarachnoid hemorrhage (aSAH). In this single-center study, serum concentrations of 10 potential biomarkers, together with clinical and demographic parameters, for 66 aSAH patients were recorded within 24 h after aSAH. The dataset was split into a training set (43 patients) and a validation set. Correlation heatmaps for both datasets were computed. Variables with inconsistent correlations on the two subsets were excluded. Clusters of relevant biomarkers were identified on the complete set, separately for patients who developed post-aSAH CVS and those who did not. Two clusters were found to be specific for patients who suffered from CVS: mitochondrial gene fragments (cytochrome B (Cyt-B), cytochrome C oxidase subunit-1 (Cox-1), displacement loop (D-loop), and IL-23, and the other one, containing IL-6, IL-10, age, and Hunt and Hess score. Clusters of serum biomarkers, analyzed within 24 h of the onset of aSAH, days before the CVS development, are expressed differently in patients suffering from post-aSAH CVS, compared to patients without CVS. This suggests that these biomarkers may be involved in the pathophysiological processes leading to CVS and may be used as its early predictors. These interesting findings are potentially highly relevant for the management of CVS and call for validation on a larger sample of patients.
Regime shift and changes in sediment morphology driven by sea level rise affect abundance of migratory waders
Authors: Laursen Karsten , Bregnballe Thomas , Kleefstra Romke , Frikke John , Günther Klaus , Hornman Menno , Pedersen Claus L. , Blew Jan , Pape Møller Anders 
Published: March 2023

AbstractRegime shifts are likely to have strong impacts on all trophic levels and their interactions. In addition, weather conditions and sea level rise together with tidal currents may change sediment morphology in coastal areas and estuaries. Here, we studied the effects of these drivers of ecosystems on abundance of seven wader species feeding on macrozoobenthos in the German sector of the Wadden Sea. We hypothesized that regime shift caused decreases in wader abundance and that changes in sediment morphology driven by sea level rise and tidal amplitude affected these changes. We analyzed numbers of waders on a short term, 1998–2016, that matched a large-scale geographical study of sediment morphology in the German sector, and at a long term, 1987–2019. Changes in numbers of waders were estimated as slope of coefficients of the trends of wader species numbers in the two periods. The average (se) year of decreases in numbers of waders was initiated for most species and tidal basins in the year 1992 (± 0.4) that followed a regime shift in the Southern North Sea and in the Wadden Sea in 1988–1989. There were no statistical differences between the years when numbers of waders started to decrease between the northern and the southwestern tidal basins of the German sector, indicating that the drives affected both coastal sections simultaneously. Significant relationships were found between slopes of coefficients of wader species and sediment morphology and physical features as sea level rise and tidal amplitude. Relationships were most pronounced for the long term, 1987–2019 compared to the short term, 1998–2016. We conclude that regime shift and changes in sediment morphology driven by sea level rise and sediment change can affect abundance of migratory wader species in large estuaries and shallow coastal waters.
FinnSentiment: a Finnish social media corpus for sentiment polarity annotation
Authors: Lindén Krister , Jauhiainen Tommi , Hardwick Sam 
Published: March 2023

AbstractSentiment analysis and opinion mining are essential tasks with many prominent application areas, e.g., when researching popular opinions on products or brands. Sentiments expressed in social media can be used in brand name monitoring and indicating fake news. In our survey of previous work, we note that there is no large-scale social media data set with sentiment polarity annotations for Finnish. This publication aims to remedy this shortcoming by introducing a 27,000-sentence data set annotated independently with sentiment polarity by three native annotators. We had three annotators annotate the whole data set, which provides a unique opportunity for further studies of annotator behavior over the sample annotation order. We analyze their inter-annotator agreement and provide two baselines to validate the usefulness of the data set.
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors
Authors: Jimeno Antonio , Baranda Joaquina , Iams Wade T. , Park Jong Chul , Mita Monica , Gordon Michael S. , Taylor Matthew , Dhani Neesha , Leal Alexis D. , Neupane Prakash , Eng Cathy , Yeku Oladapo , Mita Alain , Moser Justin C. , Butler Marcus , Loughhead Scott M. , Jennings Julia , Miselis Nathan R. , Ji Rui-Ru , Nair Nitya , Kornacker Martin , Zwirtes Ricardo F. , Bernstein Howard , Sharei Armon 
Published: March 2023

SummaryWe conducted a dose escalation Phase 1 study of autologous PBMCs loaded by microfluidic squeezing (Cell Squeeze® technology) with HPV16 E6 and E7 antigens (SQZ-PBMC-HPV), in HLA-A*02+ patients with advanced/metastatic HPV16+ cancers. Preclinical studies in murine models had shown such cells resulted in stimulation and proliferation of antigen specific CD8+ cells, and demonstrated antitumor activity. Administration of SQZ-PBMC-HPV was every 3 weeks. Enrollment followed a modified 3+3 design with primary objectives to define safety, tolerability, and the recommended Phase 2 dose. Secondary and exploratory objectives were antitumor activity, manufacturing feasibility, and pharmacodynamic evaluation of immune responses. Eighteen patients were enrolled at doses ranging from 0.5 × 106 to 5.0 × 106 live cells/kg. Manufacture proved feasible and required < 24 h within the overall vein-to-vein time of 1 – 2 weeks; at the highest dose, a median of 4 doses were administered. No DLTs were observed. Most related TEAEs were Grade 1 – 2, and one Grade 2 cytokine release syndrome SAE was reported. Tumor biopsies in three patients showed 2 to 8-fold increases in CD8+ tissue infiltrating lymphocytes, including a case that exhibited increased MHC-I+ and PD-L1+ cell densities and reduced numbers of HPV+ cells. Clinical benefit was documented for the latter case. SQZ-PBMC-HPV was well tolerated; 5.0 × 106 live cells/kg with double priming was chosen as the recommended Phase 2 dose. Multiple participants exhibited pharmacodynamic changes consistent with immune responses supporting the proposed mechanism of action for SQZ-PBMC-HPV, including patients previously refractory to checkpoint inhibitors.
Integrated machine learning–based model and WQI for groundwater quality assessment: ML, geospatial, and hydro-index approaches
Authors: Abu El-Magd Sherif Ahmed , Ismael Ismael S. , El-Sabri Mohamed A. Sh. , Abdo Mohamed Sayed , Farhat Hassan I. 
Published: March 2023

Abstract
The demands upon the arid area for water supply pose threats to both the quantity and quality of social and economic activities. Thus, a widely used machine learning model, namely the support vector machines (SVM) integrated with water quality indices (WQI), was used to assess the groundwater quality. The predictive ability of the SVM model was assessed using a field dataset for groundwater from Abu-Sweir and Abu-Hammad, Ismalia, Egypt. Multiple water quality parameters were chosen as independent variables to build the model. The results revealed that the permissible and unsuitable class values range from 36 to 27%, 45 to 36%, and 68 to 15% for the WQI approach, SVM method and SVM-WQI model respectively. Besides, the SVM-WQI model shows a low percentage of the area for excellent class compared to the SVM model and WQI. The SVM model trained with all predictors with a mean square error (MSE) of 0.002 and 0.41; the models that had higher accuracy reached 0.88. Moreover, the study highlighted that SVM-WQI can be successfully implemented for the assessment of groundwater quality (0.90 accuracy). The resulting groundwater model in the study sites indicates that the groundwater is influenced by rock-water interaction and the effect of leaching and dissolution. Overall, the integrated ML model and WQI give an understanding of water quality assessment, which may be helpful in the future development of such areas.
Mesoporous carbon nitride supported MgO for enhanced CO2 capture
Authors: Refaat Zakaria , Saied Mohamed El , Naga Ahmed O. Abo El , Shaban Seham A. , Hassan Hanaa B. , Shehata Mohamed Refaat , Kady Fathy Y. El 
Published: March 2023

Abstract
The growing concern about the environmental consequences of anthropogenic CO2 emissions significantly stimulated the research of low-cost, efficient, and recyclable solid adsorbents for CO2 capture. In this work, a series of MgO-supported mesoporous carbon nitride adsorbents with different MgO contents (xMgO/MCN) was prepared using a facile process. The obtained materials were tested for CO2 capture from 10 vol% CO2 mixture gas with N2 using a fixed bed adsorber at atmospheric pressure. At 25 ºC, the bare MCN support and unsupported MgO samples demonstrated CO2 capture capacities of 0.99, and 0.74 mmol g−1, respectively, which were lower than those of the xMgO/MCN composites.The incorporation of MgO into the MCN improved the CO2 uptake, and the 20MgO/MCN exhibited the highest CO2 capture capacity of 1.15 mmol g−1 at 25 °C. The improved performance of the 20MgO/MCN nanohybrid can be possibly assigned to the presence of high content of highly dispersed MgO NPs along with its improved textural properties in terms of high specific surface area (215 m2g−1), large pore volume (0.22 cm3g−1), and abundant mesoporous structure. The efffects of temperature and CO2 flow rate were also investigated on the CO2 capture performance of 20MgO/MCN. Temperature was found to have a negative influence on the CO2 capture capacity of the 20MgO/MCN, which decreased from 1.15 to 0.65 mmol g−1with temperature rise from 25 C to 150º C, due to the endothermicity of the process. Similarly, the capture capacity decreased from 1.15 to 0.54 mmol g−1 with the increase of the flow rate from 50 to 200 ml minute−1 respectively. Importantly, 20MgO/MCN showed excellent reusability with consistent CO2 capture capacity over five sequential sorption–desorption cycles, suggesting its suitability for the practical capture of CO2.
Measuring stock market integration during the Gold Standard
Authors: Stuart Rebecca 
Published: March 2023

AbstractThis paper uses a broad geographical sample of economies to study stock market integration during the classical Gold Standard. It is novel in estimating a common or “global” component of stock market returns across all countries in the sample and studying how individual markets co-move with this. Variations in the integration of individual exchanges often appear related to large domestic financial and political crises as idiosyncratic shocks were more common than they are today. The results suggest that although overall integration rose during this period, it was low compared to more recent data. The results are robust to alternative formulations of the global component and alternative measures of returns.