bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liquefaction assessment using alternative approaches: a case study of Ho Chi Minh City stratigraphy
Authors: DOAN NHAT-PHI , Nguyen Van Nam , Doan Duy Triet , Park Sung-Sik 
Published: March 2023

Abstract

Liquefaction has been known as a phenomenon in which the shear strength and stiffness of saturated soil are reduced by the generation of pore water pressure under earthquake loading. Consequently, liquefaction-induced settlement can result in severe damages including building cracks or slope failure, which pose a threat to human lives and properties. In the current Vietnamese standard TCVN 9386:2012, liquefaction potential hazard is often evaluated using the simplified method, which solely identifies the areas with a high risk of liquefaction. Prediction of Safety Factor (FS), Settlement (S), Liquefaction Potential Index (LPI), and Liquefaction Severity Number (LSN) has not received sufficient attention to a completeness standard. This study assesses the liquefaction of the ground at Ho Chi Minh City, Vietnam by using four conventional methods: the simplified procedure, linear equivalent analysis, loosely-coupled effective stress analysis, and fully-coupled effective stress analysis based on standard penetration test (SPT) data in Ho Chi Minh Metropolitan City. A class of seismic events that are compatible with the design response spectrum in the Vietnamese standard TCVN 9386:2012 is used as input ground motion at the bedrock. According to the results of different methods, maps of ground settlement, LPI, and LSN are proposed as useful references for construction works on such ground, which may have a high potential for liquefaction and subsidence.
Prediction of Coral Sea tropical cyclone power and latitude of maximum intensity using climate indices
Authors: Miller John G. , Silva Guilherme Vieira da , Strauss Darrell 
Published: March 2023

Abstract

Tropical cyclone (TC) wind power, often highly destructive, can be quantified using the power dissipation index (PDI) and in this study, the PDIs for Coral Sea TC tracks, as well as the latitude of maximum intensity (LMI) were investigated for correlation with climatological indices. Multiple linear regression with collinearity removed and an overall Pearson correlation of 0.7 or above was used for this. The results for all tracks showed that three indices dominated for PDI: Niño 4 Sea Surface Temperature (SST), the Dipole Mode Index (DMI) and the Madden Julian Oscillation (MJO). The TC tracks clustered by maximum windspeed-weighted locations were then examined: For cluster 1 (located SE Australia), the additional influence of the Southern Annular Mode (SAM) was apparent, whilst for cluster 2 (located NW Australia), the same indices dominated as for the all-tracks model. For LMI, four indices were identified: the Indian Ocean East SST Anomaly (DMI E), the MJO, the Southern Oscillation Index (SOI) and the SAM. Only TCs clustered in the northeast of Australia had a valid model for LMI, with correlation 0.8, using three indices: DMI E, DMI and the SOI. Overall, raised Niño 4 SST combined with a negative DMI and low MJO amplitude were shown to predict large increases in TC power, whilst a combination of increasing DMI E temperature anomaly with a positive SOI moves LMI equator-wards. Improved understanding of the relative influences of the climate indices on TC power dissipation has direct ramifications for the future risk/hazard profile of coastal communities.
Effects of maternal subclinical hypothyroidism on neurodevelopment of offspring-An animal-based study
Authors: Farhat Sabah , Fatima Syeda Sadia , Iqbal Mehirunisa , Arain Fazal 
Published: March 2023

Abstract

Background: Subclinical hypothyroidism (SCH) is characterized by high thyroid stimulating hormone (TSH) levels (4.5 to 10 IU/L) and normal T3 and T4 hormones. It may occur with or without mild symptoms of hypothyroidism and autoimmunity. In pregnancy one of the common complications is SCH. Multiple adverse maternal and neonatal outcomes such as cognitive and neuropsychiatric effects are associated with SCH. Globally, 3-15% of the general population is affected by SCH. In Pakistan, the prevalence of SCH is ~ 8.1% in women during gestation. This study was conducted to see the effects of maternal SCH during pregnancy on young rats in terms of behavioural and gross brain structure changes and their reversibility after treatment with levothyroxine. Method: 14 Female Sprague Dawley rats (200–300g) were acclimatized and allowed to get impregnated. They were divided into 3 groups. 1. Treated (n=4): was induced with SCH by propylthiouracil (PTU) 5µg/kg/day at PD6 and treated with levothyroxine from gestational day 16 to postnatal day 40. 2. Untreated (n=5): was induced with SCH and left untreated. 3. Control (n=5) was administered with equal volumes of saline. Body weight of pups was recorded regularly. Histological procedures were performed at postnatal day 7, 14 and 21 to identify any neonatal neurological problems. Behavioural tests such as elevated plus maze, forced swim and tail suspension tests were performed to test anxiety and depression. Result: On postnatal day 7, pups from the untreated mothers showed a substantial decline in body weight compared to treated and control groups. These differences were more profound with age at P14 and P21. No major changes were seen in the gross brain structure of untreated rats as compared to treated rats. The most depressed behaviour was found in pups from untreated dams evident from significantly increased immobility time in FST and TST as compared to healthy ones. Conclusion: Despite the absence of any gross changes in the brain structure, minor but significant behavioural difference, indicative of depression, was observed in the pups of untreated rats.
A Comparative Analyses of Lipid Ratios Representing Desaturase Enzyme Activity between Preterm and Term Infants Within the First Ten Weeks of Life
Authors: Kasim Hanis Hidayu , Olga Laurentya , Snowden Stuart , Cropp Eliza , Koulman Albert , Beardsall Kathrynn 
Published: March 2023

Abstract
Background
Desaturase enzymes play a key role in several pathways including biosynthesis of poly unsaturated fatty acids (PUFAs). In preterm infants, desaturase enzyme activity (DA) may be a rate-limiting step in maintaining PUFAs levels during this critical developmental window and impact on long term metabolic health. The study tested the hypothesis that desaturase enzyme activity is altered in preterm infants compared to term infants in early life.
Methods
Lipidomic analyses were conducted using blood samples from two established UK-based cohorts, involving very preterm (n = 105) and term (n = 259) infants. Blood samples were taken from term infants at birth, two and six weeks and from preterm infants when established on enteral feeds and at term corrected age. DA of the 2 groups of infants were estimated from product/precursor lipids ratios of phosphatidylcholine (PC) and triglycerides (TG) species and reported according to their postmenstrual and postnatal ages.
Results
There were changes in lipid ratios representing desaturase enzyme activity in preterm infants in the first weeks of life with increasing activity of fatty acid desaturase 2 (FADS2) TG but a significant reducing activity of stearoyl-COA desaturase (SCD1) and FADS2(PC). In comparison to term infants, preterm have lower FADS1 but higher FADS2 at all postnatal ages. Although point levels of DA were different, trajectories of changes in DA over time were similar in preterm and term infants.
Conclusions
This study findings suggest the patterns of DA in preterm infants differ from that of term infants but their trajectories of change in the first 10 weeks of life were similar. These differences of desaturases activity if they persist in later life could contribute to the mechanism of diseases in preterm adulthood and warrant further investigations.
Association between macronutrient intake and liver dysfunction among tuberculosis patients in rural China
Authors: Liangjie Zhao , Li Mingxin , Li Yue , Hao Haibo , Zhao Shanliang , Ma Aiguo , Cai Jing 
Published: March 2023

Abstract
Background
Macronutrients play a vital role in liver dysfunction and affect the treatment and prognosis of tuberculosis. This study aimed to clarify the associations between macronutrients intakes or to energy percentages and liver dysfunction in tuberculosis patients.
Methods
In this cross-sectional study, 2695 active tuberculosis patients aged ≥ 18 years were included based on the data from local tuberculosis clinics in Linyi rural areas, China. Macronutrients intakes and to energy percentages were assessed by the 24-hour dietary recalls. The concentration of alanine transferase (ALT) or aspartate transaminase (AST) greater than 40 U/L was defined liver dysfunction. In addition, restricted cubic spline (RCS) was applied to determine the dose-response relationships.
Results
Among those who were male, or normal BMI, or consumed energy less than 1646.80 kcal/d, it was suggested both inverse associations between protein (47.30–78.80 g/d) or fat (> 20.30 g/d) intake and the risks of liver dysfunction in all models (all P-trend < 0.05). Moreover, the RCS model showed J-shaped associations between protein, fat intake, the fat or carbohydrate to energy percentages and the odds of liver dysfunction (the cut-off values = 70.69 g/d, 47.50 g/d, 22% and 69%, respectively, and all P-nonlinearity < 0.05).
Conclusions
An appropriate increase in dietary intakes of protein or fat might reduce liver dysfunction risk. However, intakes of more than 70.69 g/d for protein or 47.50 g/d for fat could increase the risk of liver dysfunction. Our study may provide a novel idea of alleviating liver dysfunction with nutritional improvement.
Water productivity and production of grape tomatoes under different irrigation regimes controlled by modeled substrate matric potential
Authors: de Freitas Fabio Tayrone Oliveira , Silva Alisson Jadavi Pereira da , Vellame Lucas Melo 
Published: March 2023

Abstract

The knowledge of critical limits of water potential in the substrate (Ψ) allows performing irrigations that do not exceed the capacity of water storage in the substrate and do not harm crop yield through water stress of plants. This is an irrigation management strategy particularly useful for automation of soil water sensing systems. In this study, substrate water retention curve was determined by inverse modeling and originated two ranges of Ψ used as a reference for irrigation scheduling: range 1, upper critical (UP Ψ) = -6 kPa and lower critical (LC Ψ) = -40 kPa; and range 2, UP Ψ = -14 kPa and LC Ψ = -40 KPa. These limits were applied in the irrigation scheduling of grape tomato in a fixed form and by changing the critical limits according to the crop development stage. The irrigation water productivity of tomato crop was determined as a function of variations in the values and form of application of Ψ. The experiment was carried out in a greenhouse. Tomato plants were cultivated in pots filled with substrate, fertigated by an automated drip irrigation system. Tomato evapotranspiration was determined using a weighing lysimeter. Soil water content was monitored by GS1 and TDR100 sensors. Grape tomato yield was not significantly affected by the different ranges of Ψ applied. On the other hand, water productivity was statistically higher in plants subjected to range 2 throughout the crop cycle and when this range was applied in at least one of the crop development stages.
The Effect of the JAK-inhibitor Tofacitinib on Chondrocyte Autophagy in Osteoarthritis
Authors: Zhang Ping , Xiao Juan , Luo Chenggen , Liu Xiaorui , Li Chunyan , Zhao Jing , Liu Xu , Pan Xiaoli , Tian Mei 
Published: March 2023

Abstract

Osteoarthritis (OA) is a multifactorial disease of the whole joint that has a complex pathogenesis. There is currently no cure for OA. Tofacitinib is a broad JAK inhibitor that can have an anti-inflammatory effect. The objective of this study was to investigate the effect of tofacitinib on the cartilage extracellular matrix in OA and determine whether tofacitinib exerts a protective effect by inhibiting the JAK1/STAT3 signaling pathway and upregulating autophagy in chondrocytes. We established an vitro OA model by exposing SW1353 cells to interleukin-1β (IL-1β) and induced OA in rats using the modified Hulth method. We found that IL-1β promoted the expression of OA-related matrix metalloproteinases (MMP-3 and MMP-13), reduced the expression of collagen II, reduced the expression of beclin1 and LC3-II/I, and promoted the accumulation of p62 in SW1353 cells. Tofacitinib attenuated IL-1β-stimulated changes in MMPs and collagen II and restored chondrocyte autophagy. In IL-1β-stimulated SW1353 cells, the JAK1/STAT3 signaling pathway was activated. Tofacitinib inhibited the IL-1β-stimulated expression of p-JAK1 and p-STAT3 and prevented translocation of p-STAT3 to the nucleus. In the rat model of OA, tofacitinib reduced articular cartilage degeneration by delaying cartilage extracellular matrix degradation and increasing chondrocyte autophagy. Our study demonstrates that chondrocyte autophagy was impaired in experimental models of OA. Tofacitinib reduced the inflammatory response and restored the damaged autophagic flux in OA.
Development and implementation of in-process, orbiting laser-assisted healing technique on fused filament fabrication
Authors: Han Pu , Zhang Sihan , Tofangchi Alireza , Izquierdo Julio , Torabnia Shams , Hsu Keng 
Published: March 2023

Abstract
Fused filament fabrication is one of the most widely used additive manufacturing processes for producing thermal plastic polymer materials due to the affordable cost and capability to build objects with complex structures. However, parts fabricated with this process exhibit lower mechanical strength when compared to parts manufactured using traditional methods. In this work, an in-process orbiting laser healing technique is developed and implemented on a 3D printer to enhance mechanical strength by improving interlayer adhesion. The orbiting laser assembly can position and align the laser-heated spot before the change of nozzle direction occurs, ensuring that the previous layer is heated prior to material deposition. This laser-heating technique increases the bending strength along build direction by 40% and reaches 88.9% of strength along track direction. With this technique, the displacement at facture also increased by 54.3% compared to control sample. The thermal profile of the melting pool and fracture surface was further characterized using a thermal camera and SEM to support the effect of laser heating on polymer microstructure, respectively. Due to its enhanced print quality and lower cost, this technique has the potential to expand the application field of fused filament fabrication to small batch and series production that are currently dominated by injection molding, as well as the high-quality prototyping field.
Influence of Adaptive Coupling Points on Coalition Formation in Multi-Energy Systems
Authors: Schrage Rico , Nieße Astrid 
Published: March 2023

Abstract
The share and variants of coupling points (CPs) between different energy carrier networks (such as the gas or power grids) are increasing, which results in the necessity of the analysis of so-called multi-energy systems (MES). One approach is to consider the MES as a graph network, in which coupling points are modeled as edges with energy efficiency as weight. On such a network, local coalitions can be formed using multi-agent systems leading to a dynamic graph partitioning, which can be a prerequisite for the efficient decentralized system operation. However, the graph can not be considered static, as the energy units representing CPs can shut down, leading to network decoupling and affecting graph partitions. This paper aims to evaluate the effect of network adaptivity on the dynamics of an exemplary coalition formation approach from a complex network point of view using a case study of a benchmark power network extended to an MES. This study shows: first, the feasibility of complex network modeling of MES as a cyber-physical system; second, how the coalition formation system behaves, how the coupling points impact this system, and how these impact metrics relate to the CP node attributes.
The Role of Glycogen Synthase Kinase-3β in Zinc Mediated Neuroprotective Effect of Metformin in Rats With Glutamate Neurotoxicity
Authors: Oruc Aykut , Oruc Kadriye Yagmur , Yanar Karolin , Mengi Murat , Caglar Aysel , Kurt Bahar Ozturk , Altan Mehmet , Sonmez Osman Fuat , Cakatay Ufuk , Uzun Hafize , Simsek Gonul 
Published: March 2023

Abstract
Metformin has been suggested to have protective effects on the central nervous system with an unclarified mechanism. The similarity between the effects of metformin and the inhibition of glycogen synthase kinase (GSK)-3β suggests that metformin may inhibit GSK-3β. In addition, zinc is an important element that inhibits GSK-3β by phosphorylation. In this study, it was investigated whether the effects of metformin on neuroprotection and neuronal survival were mediated by zinc-dependent inhibition of GSK-3β in rats with glutamate-induced neurotoxicity. Forty adult male rats were divided into 5 groups; Control, Glutamate, Metformin + Glutamate, Zinc Deficiency + Glutamate, Zinc Deficiency + Metformin + Glutamate. Zinc deficiency was induced with a zinc-poor pellet. Metformin was given orally for 35 days. D-glutamic acid was administered intraperitonally on the 35th day. On the 38th day, neurodegeneration was examined histopathologically and effects on neuronal protection and survival were evaluated via intracellular S-100β immunohistochemical staining. The findings were examined in relation to non-phosphorylated (active) GSK-3β levels and oxidative stress parameters observed in brain tissue and blood. Neurodegeneration was higher (p < 0.05) in rats fed with an inadequate zinc diet. Active GSK-3β levels were increased in groups with neurodegeneration (p < 0.01). Decreased neurodegeneration and increased neuronal survival (p < 0.01); decreased active GSK-3β (p < 0.01) levels and oxidative stress parameters, and increased antioxidant parameters were observed in groups treated with metformin (p < 0.01). Metformin had less protective effects in rats fed with an inadequate zinc diet. Metformin may demonstrate its neuroprotective effects and may increase S-100β mediated neuronal survival by a zinc-dependent inhibition of GSK-3β in glutamate neurotoxicity.
A simple neural model for unlabelled data
Authors: Çiftçi Ünver 
Published: March 2023

Abstract
Neural networks are powerful tools for modelling big unstructured data. Advanced architectures and learning methods are used in applications. Nevertheless simpler models which use less data could be helpful. We propose a very simple learning algorithm in order to model the data distribution. Experiments show how effective and data-efficient our method is. Code is available at https://github.com/unverciftci/toUniform.
In situ synthesis of AuNPs by hyperbranched polyethyleneimine-functionalized apple pomace-derived cellulose as recyclable catalysts for 4-nitrophenol reduction
Authors: Lin Tao , Li Yuxi , Zhang Jifan , Zhang Yixun , Huo Kefeng , Liu Yi , Liu Xunyong 
Published: March 2023

Abstract
To improve the utilization rate of apple pomace and the catalytic stability and recycling performance of gold nanoparticles (AuNPs), as well as realize the high value utilization of inexpensive materials and the reuse of expensive materials, a recyclable AuNP catalyst based on hyperbranched polyethyleneimine-dialdehyde cellulose (HPEI-DAC) was developed. We used apple pomace as raw material to extract cellulose and oxidize it into easily modifiable DAC. A novel HPEI-DAC carrier with both reduction performance and easy separation performance was successfully prepared by grafting HPEI onto DAC through a Michael addition reaction. Taking advantage of the reduction properties and special topology of HPEI-DAC, AuNPs with high stability were prepared in situ. The prepared AuNPs/HPEI-DAC had high catalytic activity and reusability, which could realize the catalytic reduction of 4-nitrophenol (4-NP) and the recovery of AuNPs after catalysis. At 25 ℃, the catalytic efficiency of AuNPs/HPEI-DAC only decreased from 100% to 91% after being reused 6 times that was, its catalytic activity did not decrease significantly. These results show that the catalyst has excellent catalytic performance and reusability in reducing 4-NP organic pollutants and is expected to be used as an ideal catalyst in environmental treatment and other fields.
Some q-supercongruences for double basic hypergeometric series
Authors: Wei Chuanan , Li Chun 
Published: March 2023

Abstract
In terms of the creative microscoping method, El Bachraoui’s lemma, and the Chinese remainder theorem for coprime polynomials, we establish some q-supercongruences for double basic hypergeometric series modulo the fifth and fourth powers of a cyclotomic polynomial. Several related conjectures are also proposed for further research.
AMS Subject Classifications: 11A07, 11B65
Morphological and molecular characterization of multiplier onion (Allium cepa var. aggregatum) genotypes
Authors: Gupta Amar Jeet , Khade Yogesh P. , Mahajan V , Hange SR , Shalaka RS , Singh Major 
Published: March 2023

Abstract
Multiplier onion (Allium cepa var. aggregatum), commonly known as shallot or potato onion, has been cultivated on a large scale in southern parts of India. It is mostly propagated by bulbs except few genotypes which produces seeds. It is famous for its use in the preparation of sambar which is an important South Indian dish. The multiplier onion produces 6–15 small bulbs in a cluster. Thus, its morphological and molecular characterization is an essential part for the genetic improvement. An experiment was laid out in the experimental field of ICAR-DOGR, Rajgurunagar, Pune during rabi 2019-20 and 2020-21 for screening of multiplier onion lines suitable for domestic as well as export purpose. The genotype 1534-Agg recorded highest total yield (287.17 q/ha). Molecular characterization of the multiplier onion was performed using recently produced polymorphic DNA-based molecular markers in onions (ILP-Intron Length Polymorphism markers). The genetic diversity of 36 genotypes of multiplier onion was examined using 17 ILP markers in this study. PIC values ​​ranged from 0.03 to 0.44 with a mean of 0.24, and amplification of ILP markers revealed a total of 41 loci, one of which was monomorphic. A total of 1008 bands were obtained. Principal component analysis (PCA) detected one PC contributing 54.54% of the genetic diversity of genotypes. A total of 17 primers were amplified and they produced 41 alleles in these genotypes. The genotypes 1539-Agg and 1523-Agg have the highest degree of similarity (0.97) in cluster A whereas, the least degree of similarity was revealed in cluster E between genotypes 1549-Agg and 1533-Agg. The genetic diversity among multiplier onion genotypes was estimated based on similarity coefficient of molecular markers facilitates the selection of diverse parents that can generate desirable segregants in future breeding program.