bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mine Induced Airblast prediction: An Application of Chaos Game Optimization based soft computing approaches
Authors: Hosseini Shahab , Taiwo Blessing Olamide , Fissha Yewuhalashet , Sakinala Vikram , Chandra N Sri , Famobuwa Oluwaseun Victor , Akinlabi Adams Abiodun 
Published: May 2023

Abstract

Air overpressure, often known as AOp, is one of the unfavourable effects of galena blasting. It has high damage potential to structural buildings, ecosystem, and occasionally endanger mine workers due to the ore characteristics. The efficiency of most available techniques to manage this mine challenge is site specific and sometimes limited by poor prediction accuracy. In the current study, several deep and machine learning approaches have used to develop blast-induced AOP prediction models as a way forward to the recent gap. These techniques include, Long Short-Term Memory (LSTM), Multi-Layer Perceptron (MLP), Support Vector Regression (SVR), Random Forest (RF), and Multivariate Adaptive Regression Splines (MARS). To achieve the research aim, 90 measured field data sets were monitored and collected from the Anguran open-pit lead-and-zinc mine (Iran). To improve the proposed model performance, chaos game optimisation (CGO) as a nature-inspired algorithm was adopted. The optimized models were compared with each other and as well with the ordinary models to determine the model with the best prediction accuracy. The results show that, in terms of accuracy levels, the performance of hybrid algorithm approach is superior to that of single based models. The LSTM-CGO model, out of the 10 proposed models, has the highest prediction accuracy statistically. This study demonstrated how well deep learning techniques provide solution to safe and environmental friendly mining operation. The proposed soft computing models are applicable as a tool to forecast AOP in surface mine blasting operation as a pre-blast design decision making reference.
Thermal Expansion of Silicon Between 293k and 873k Using a Capacitor Dilatometer
Authors: Altshuler Thomas L. 
Published: May 2023

Abstract
A fused silica dilatometer consisted of a rod and tube that had capacitance discs attached at one end. The cylindrical specimen of polycrystalline pure silicon 2.54 centimeters long and 0.635 centimeters in diameter was clamped between the other end of the rod and tube. These were enclosed in a fused silica furnace tube within the furnace. The furnace tube was sealed with helium that did not flow. The capacitance discs were sealed in a container outside of the furnace. Helium flowed within that container. These disks were used to measure the thermal expansion of pure silicon between 200 and 600 Celsius. The capacitance measurements were made by an Andean Hager ling capacitance bridge with a readout of ten digits and a sensitivity of 0.5 attofarads. The rate of heating and cooling was 10C per minute. The specimen temperature was measured using a calibrated platinum thermometer 3 millimeters away from the specimen. To correct for changes in disc expansion during a test, a silicon diode measured the temperature. Calibration of the capacitor extensometer was made using NIST fused silica and NIST stainless steel. The total thermal expansion of three silicon specimens measured between 200 and 600 Celsius was 2074.83 strain with a standard deviation of 17.43 strain. The hysteresis difference between the warming and cooling curves for the silicon was less than 7 strain.
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Authors: Watamura Naoto , Foiani Martha , Bez Sumi , Frodsham Claire , Kamano Naoko , Takahashi Mika , Bourdenx Mathieu , Camporesi Elena , Brinkmalm Gunnar , Turkes Emir , Patel Saisha , Hashimoto Shoko , Sasaguri Hiiroki , Saito Takashi , Seico BENNER , Endo Toshihiro , Kobayashi Katsuji , Ishida Chiho , Zetterberg Henrik , Yamada Masahito , Duff Karen , Saido Takaomi 
Published: May 2023

Abstract

Tau pathology is a hallmark feature of several neurodegenerative diseases including frontotemporal dementia (FTD) spectrum and Alzheimer’s disease. The accumulation of pathological tau is linked to cognitive impairment. However, the sequence of events and the form of tau that confers toxicity are still unclear, due to the lack of physiological models of tauopathy initiation and progression in which to test hypotheses. We have developed a series of novel, targeted mice expressing FTD-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy. MAPTInt10+3G>A and MAPTS305N;Int10+3G>A lines show abundant hyperphosphorylated tau in the hippocampus and entorhinal cortex but no seed-competent fibrillar structures. Accumulation of hyperphosphorylated tau was accompanied by neurite degeneration, loss of viable synapses and indicators of behavioral abnormalities. Our results demonstrate that neuronal toxicity can occur in the absence of fibrillar, higher-order structures and confirm that tau hyperphosphorylation plays a role in the earliest etiological events in tauopathy.
Study of peculiar behaviour of gas flow in microchannel with 90° bends
Authors: Singh H. S. , Subbarao P. M.V 
Published: May 2023

Abstract
The most often found element of complex microchannel in microdevices is microchannel having 90° bend/bends. Study of the flow through these channels is needed to know the flow physics through it. In this article, the peculiar behaviour of gas flow through microchannel with 90° bends was investigated using experimental and numerical analysis within slip regime. Microchannel system of twenty channels having dimensions 1.03 × 393.96 × 25200 µm3 with 90°bend at two places was fabricated on a silicon wafer. This channel system has a common inlet and outlet passage. Nitrogen gas was used as the working fluid. Experimental data through microchannel system was obtained in slip regime with pressure ratio ranging 1.30-1.55 covering range of Knudsen number from 0.0662 to 0.0805. Study of mass flow rate ratio variation in slip regime was performed. Further, flow separation near bend corners was studied using Ansys fluent 18.1 for three dimensional numerical simulations of isothermal gas flow in slip regime.
CD147 promotes breast cancer invasion and metastasis by inducing EMT and upregulating MMPs via the MAPK/ERK signaling pathway
Authors: Li Fang , Yan Yuqiong , Guo Jiqiang , Bai Chongzhi 
Published: May 2023

Abstract
Metastatic breast cancer is the main cause of death among women worldwide. It is crucial to identify new markers associated with breast cancer metastasis in order to predict tumor progression and develop therapeutic molecular targets. In our previous study, we found that CD147 was up-regulated in breast cancer cells and promoted their invasion and metastasis. Although most epithelial tumor cells undergo epithelial-mesenchymal transition (EMT) to invade nearby tissues and metastasize, it is not clear whether EMT also participates in the invasion and metastasis of CD147-induced breast cancer. Furthermore, the MAPK/ERK signaling pathway is frequently dysregulated during malignant transformation. It remains to be elucidated whether this pathway is involved in metastatic breast cancer as well. The aim of the present study was to evaluate the molecular mechanisms underlying CD147-driven metastasis and invasion of breast cancer cells. We analyzed the expression of CD147 in four breast cancer cell lines, and found that MCF-7 cells expressed the highest levels of CD147 mRNA and protein, whereas the BT549 cells had the lowest expression levels. Knocking down and overexpressing CD147 in the MCF-7 and BT549 cells respectively altered the expression levels of E-cadherin, vimentin and MMP-9, indicating that CD147 regulates EMT of breast tumor cells. Furthermore, the CD147 expression level was positively correlated with ERK phosphorylation, which suggested that the MAPK/ERK signaling pathway is involved in CD147-induced metastasis. In conclusion, our findings indicate that CD147 promotes breast cancer invasion and metastasis by inducing EMT and upregulating MMPs via the MAPK/ERK signaling pathway.
Comprehensive analysis of clinical significance and potential molecular mechanism of PAX gene family in lung squamous cell carcinoma
Authors: Zhang Weiming , Chen Hui , Cai Junlan , Zhang Xiaowen , Tang Yating , Cai Xiaolian , Wei Lijuan , Zeng Yong 
Published: May 2023

Abstract
Purpose The paired box(PAX) gene family encodes a group of putative transcription factors and associates with pathogenesis and development of various cancers. However, the role of PAX gene family in lung squamous cell carcinoma (LUSC) remains largely unknown. This study aimed to explore its clinical significance and potential molecular mechanism in LUSC.
Methods LUSC data was downloaded from TCGA and GEO database to analyze the correlation between PAX gene family and LUSC prognostic. The possible mechanism of PAX gene family acting on LUSC was explored via biological information annotation. The co-expression and interaction network analysis method were performed among PAX gene family and relative genes.
Results Significant differential expression of PAX gene family was found between LUSC and normal tissues. Prominently, PAX9 showed the strongest diagnostic ability for LUSC. According to Cox model, PAX9 might be an independent prognostic factor of LUSC. GO and KEGG analysis suggested PAX gene family was related to transcription, DNA binding, etc. PAX9 co-expressed with the genes included KRT13, TMPRSS4, etc. and might act on LUSC through pathways such as MYC pathway, EIF pathway, etc.
Conclusion PAX9 is expected as a potential target for the diagnosis and prognostic of LUSC.
ANALISIS RASIO KEUANGAN DAERAH UNTUK MENILAI KINERJA KEUANGAN DAERAH DI WILAYAH MATARAMAN TAHUN 2019-2020
Authors: Atmaja Deby Kusuma , Himmati Risdiana 
Published: May 2023

Abstrak: Tujuan penelitian ini adalah guna mengetahui kinerja keuangan daerah di wilayah Mataraman di masa pandemic Covid-19 dilihat dari Rasio Kemandirian Keuangan Daerah, Rasio Efektivitas PAD, Rasio Efisiensi Keuangan Daerah, dan Rasio Pertumbuhan. Data yang yang digunakan pada penelitian ini menggunakan data sekunder dengan menggunakan metode deskriptif kuantitatif. Metode yang digunakan pada penelitian ini menggunakan purposive sampling. Hasil penelitian ini menunjukan Rasio Kemandirian Keuangan Daerah sudah optimal karena peran pemerintah daerah tidak terlalu dominan dalam pelaksanaan program dan kegiatan yang dilaksanakan oleh daerah, Rasio Efektivitas menunjukan ketidakefektivitas dalam sektor keuangan dikarenakan tidak sesuainya realisasi PAD dengan target penerima sehingga menyebabkan dana yang akan direalisasikan pada pemerintah daerah tidak mencukupi, Rasio Efisiensi sendiri menunjukan anggaran PAD stabil dengan rata-rata 0,809% di tahun 2019 dan 0,709% tahun 2020 Pada Rasio Pertumbuhan sendiri menggambarkan bahwa pertumbuhannya negatif dikarenakan tingginya PAD dan belanja operasi dengan diikutinya belanja modal yang rendah.
Kata Kunci: Rasio Kemandirian; Rasio efektivitas; Rasio Efisiensi; Kinerja Keuangan

Abstract: The purpose of this study was to determine the regional financial performance in the Mataraman area during the Covid-19 pandemic seen from the Regional Financial Independence Ratio, PAD Effectiveness Ratio, Reginoal Financial Efficiency Ratio, and Growth Ratio. The data used in this study uses secondary data using quantitative descriptive methods. The methode used in this study using purposive sampling. The results of this study indicate that the Regional Financial Independence Ratio is optimal because the role of local goverments is not too dominant in the implementation of programs and activities carried out by regions. The Effectiveness Ratio shows ineffectiveness in the financial sector due to the incompatibility of PAD realization with target recipients, causing funds to be realized in the government inadeguate regions, the Efficiency Ratio itself shows a stable PAD budget with an average of 0,809% in 2019 and 0,709% in 2020. The Growth ratio itself illustrates that the growth is negative due to high PAD and operating expenditures foolowed by low capital expenditures.
Keywords: Independence Ratio; Effectiveness Ratio; Efficiency Ratio; Financial Performance.
Focusing on the big ideas: Non-biology science teachers learning experiences on biological evolution
Authors: Picardal Marchee Tabotabo , Picardal Jay Pajanustan 
Published: May 2023

Recognizing the ways teachers develop conceptual understanding of biological concepts bridges the gap between misconception and instruction. This descriptive phenomenology explored the learning experiences of eight non-biology major science teachers on evolution. Thematic analysis revealed six emergent themes: (a) First exposure was faulty and insufficient; (b) Lack of content knowledge leads to advanced studies; (c) Technology-supported learning resources facilitated learning process; (d) Rationalization of both old and new conceptions; (e) Application of concepts in different fields; and (f) Focusing on the big ideas. Overall, themes revealed that teachers developed a conceptual understanding of biological evolution through time and various means. Their adherence to the teleological beliefs leads them to experience confusion and misconceptions; however, as science teachers, they resolved the conflict to learning through content enrichment and professional development. A strong emphasis on the core principles of the Nature of Science and domains of biology in the curriculum across all levels and the teacher education program is imperative. Teachers can enhance their conceptual understanding and teaching efficacy through professional development and content enrichment.
Information and Communication Technologies to Support the Provision of Respite Care Services: Scoping Review
Authors: Castro Aimee R , Ould Brahim Lydia , Chen Qirong , Arnaert Antonia , Quesnel-Vallée Amélie , Moffatt Karyn , Kildea John , Bitzas Vasiliki , Pang Carolyn , Hall Audrey-Jane , Pagnotta Ariana , Tsimicalis Argerie 
Published: May 2023

Background
Respite care is one of the most frequently requested support services by family caregivers. Yet, too often, respite care services are inaccessible, due in part to families’ lack of knowledge regarding available services and a lack of service flexibility. Information and communication technologies (ICTs) may help to improve the flexibility of services available and families’ knowledge of such services. However, an understanding of the use of ICTs and research in this area is lacking.

Objective
The objective of this study was to provide a comprehensive overview of the academic literature on ICTs for supporting the provision of respite care services.

Methods
A scoping review study was conducted. Six library databases were systematically searched for relevant literature. Key data were extracted into a summary chart. Text and quantitative data were coded using descriptive qualitative content analysis techniques, and the results were collated and summarized into a comprehensive narrative.

Results
A total of 23 papers describing 15 unique ICT programs exploring the potential of ICTs to support respite care services met the inclusion criteria. ICTs supported the provision of respite care by facilitating information-sharing with families and providers, recruiting and training respite care providers, and coordinating services. Key design considerations for developing respite care ICTs were trustworthiness and participatory design methods. Implementation considerations included designing for complementarity with existing services, assessing the appropriate timing for introducing the ICT-based services, and ensuring adequate promotion strategies to raise awareness about the services.

Conclusions
There is limited but promising research on the potential of ICTs to support the provision of respite care services. Further research should be conducted to advance the results of this review, ultimately aiming to build ICTs that can improve the quality of, and access to, respite care services.
Understanding Beschikking, Regeling and Beleidsregel in Indonesian Legal System
Authors: Al-Fatih Sholahuddin , Muluk Mujibur Rahman Khairul 
Published: May 2023

This article examines beschikking, regeling, and beleidseregel in the Indonesian legal system. This article aims to understand beschikking, regeling, and beleidseregel in the context of its content's type, form, and material. Using a conceptual approach method, this article will likely provide an understanding for academics and practitioners in the field of legislation. The results of this study show that beschikking in Indonesia appears in the form of KTUN. In contrast, regeling appears in the form of laws and regulations, while beleidseregel manifests in circulars and instructions. Measuring the marketability, binding, and usability of a beschikking, regeling, and beleidseregel uses a typology approach to the division of power.
Geomorfologi Karst Studi Geomorfologi Karst Pulau Muna, Provinsi Sulawesi Tenggara dan Potensinya Sebagai Geowisata
Authors: Okto Ali , Meliawati  , Hasria  , Muliddin  , Arisona  , Suryawan  , Sawaluddin  
Published: May 2023

Penelitian ini terletak di Kabupaten Muna Provinsi Sulawesi Tenggara. Kabupaten Muna merupakan daratan karst yang berkembang cukup baik terutama di bagian timur pulau Muna. Morfologi karst yang tersusun atas batugamping memiliki daya tarik tersendiri baik di bidang pertambangan maupun bidang pariwisata. Pemanfaatan batugamping dalam industri pertambangan memberikan ancaman kerusakan Kawasan karst secara langsung. Oleh sebab itu pemahaman Kawasan Karst sebagai salah satu aset pengembangan geowisata dan pelestarian lingkungan menjadi hal yang mesti diperhatikan. Analisis terhadap keragaman morfologi dan potensi geowisata menjadi hal yang sangat penting dalam menjawab hal tersebut. Penelitian ini bertujuan untuk melakukan analisis terhadap morfologi yang berkembang dan berpotensi untuk dikembangkan sebagai geowisata. Metode yang digunakan berupa observasi lapangan dan deskripsi kualitatif terhadap jenis litologi batuan dan jenis morfologinya. Jenis batuan yang ditemukan di lapangan yaitu batugamping Packstone, Weckestone dan Crystalline. Morfologi yang berkembang antara lain cliff, notch, sactk, stump, hasil endapan organisme, natural arch, danau air asin, gua, dan perbukitan bergelombang. Beberapa morfologi tersebut telah dikembangkan sebagai lokasi geowisata, tetapi masih banyak lokasi lain yang berpotensi untuk terus dikembangkan. Keberagaman morfologi karst dan unik yang terdapat di Pulau Muna memiliki potensi yang cukup besar untuk dikembangkan sebagai bagian dari geowisata Sulawesi tenggara.
PENGARUH MODEL PROBLEM BASED LEARNING BERBANTUAN MULTIMEDIA INTERAKTIF DAN COOPERATIVE LEARNING TIPE STAD PADA PEMBELAJARAN MATEMATIKA TERHADAP KEMAMPUAN HOTS (STUDI EKSPERIMEN PADA SISWA KELAS V SD DI KECAMATAN SUKASARI)
Authors: Rahmanudin Arif , Mulyasa Enco , Cahyani Isah 
Published: May 2023

Implementasi pendidikan abad 21 salah satunya diarahkan pada pembelajaran HOTS (Higher Order Thinking Skills). HOTS merupakan kompetensi penting yang diharapkan muncul sebagai hasil dari proses pembelajaran termasuk dalam pembelajaran matematika. Tujuan penelitian adalah untuk : (1) membuktikan pengaruh model problem based learning berbantuan multimedia interaktif terhadap kemampuan HOTS siswa; (2) membuktikan pengaruh model cooperative learning tipe STAD pada terhadap kemampuan HOTS siswa; (3) Menganalisis dan mendeskripsikan perbedaan pengaruh antara model problem based learning berbantuan multimedia interaktif dengan model cooperative learning tipe STAD terhadap kemampuan HOTS siswa. Metode penelitian adalah kuasi eksperimen dengan rancangan pretest-postest kelompok kontrol non ekuivalen. Populasi penelitian adalah seluruh siswa kelas V SD pada 11 Sekolah Dasar di Kecamatan Sukasari Kabupaten Purwakarta. Sampel dipilih dengan teknik random sampling. SDN 2 Sukasari sebagai kelas eksperimen dan SDN 1 Ciririp sebagai kelas kontrol. Instrumen yang digunakan adalah soal pretest dan postets untuk mengukur kemampuan HOTS siswa. Hasil penelitian membuktikan bahwa (1) Terdapat pengaruh model problem based learning berbantuan multimedia interaktif terhadap kemampuan HOTS siswa, (2) Terdapat pengaruh model cooperative learning tipe STAD terhadap kemampuan HOTS siswa, dan (3) Terdapat perbedaan pengaruh antara model problem based learning berbantuan multimedia interaktif dengan model cooperative learning tipe STAD terhadap kemampuan HOTS siswa. Kemampuan HOTS siswa yang mendapatkan pembelajaran dengan model problem based learning berbantuan multimedia interaktif lebih baik dibandingkan dengan siswa yang mendapatkan pembelajaran dengan model cooperative learning tipe STAD.
PENERAPAN MEDIA PAPAN HITUNG UNTUK MENINGKATKAN KEMAMPUAN BERHITUNG SISWA DI SDN PANDEAN LAMPER 04 SEMARANG
Authors: Hariyanti Ratna Sari , Siswanto Joko , Roshayanti Fenny , Handayaningsih Susi 
Published: May 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan berhitung siswa melalui penerapan media papan hitung pada siswa kelas 1 di SDN Pandeanlamper 04 Semarang. Penelitian ini menggunakan metode penelitian tindakan kelas yang terdiri dari kegiatan Siklus I dan siklus II. Masing-masing siklus terdiri dari 4 tahapan yaitu, tahap perencanaan, tahap pelaksanaan tindakan, tahap observasi, dan tahap refleksi. Dalam penelitian ini, instrumen yang digunakan untuk mengumpulkan data adalah tes hasil belajar, observasi dan dokumentasi. Data yang diperoleh kemudian dianalisis dengan rumus ketuntasan klasikal. Berdasarkan hasil data awal menunjukkan bahwa hasil kemampuan berhitung siswa tanpa penggunaan media papan hitung mencapai (46%) masih di bawah KKM. Namun pada Siklus I kemampuan berhitung siswa mencapai (64%), yang mana terdapat 10 siswa yang masih di bawah KKM. Akan tetapi, setelah diterapkan media papan hitung kemampuan berhitung siswa mencapai (89%) ada 3 siswa yang di bawah KKM. Maka dapat disimpulkan bahwa penerapan media papan hitung dapat meningkatkan kemampuan berhitung siswa kelas I di SDN Pandeanlamper 04 Semarang
PENGARUH PENGGUNAAN MEDIA MICROVIDIO TERHADAP KEMAMPUAN MEMBACA SISWA SEKOLAH DASAR
Authors: Maulidya Safitri Putri Andini , Liansari Vevy 
Published: May 2023

Penelitian ini untuk melihat pengaruh media mikrovideo terhadap kemampuan membaca siswa kelas III SD yang berjumlah 24 siswa yang seluruhnya menjadi sampel. Penelitian kuantitatif menggunakan eksperimen. Metode penelitian menggunakan satu kelompok dengan desain pretest – posttest, teknik pengumpulan data berupa tes lisan dengan 5 komponen. Nilai awal (bentuk huruf 3,71 elemen kata3,21, pola ejaan3,21 dan kecepatan baca3,21) dan nilai setelah perlakuan (bentuk huruf 3,79, elemen kata3,79, pola ejaan3,29, dan kecepatan membaca3,29) menyatakan bahwa terjadi peningkatan penggunaan media microvidio. Dari data di atas, disimpulkan bahwa uji hipotesis yang telah dilakukan thitung = 4,082 dan ttabel = 2,069. Jadi t hitung tabel > t. BahwaH0 ditolak dan Ha diterima, yang berarti penerapan media mikrovideo pada keterampilan membaca siswa kelas III SDI Muhammadiyah 1 Gempol berpengaruh.