bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 pandemic on nonpharmacological pain management trials in military and veteran healthcare settings: an evaluation informed by implementation science
Authors: Midboe Amanda M , Javier Sarah J , Salsbury Stacie A , Katsovich Lily , Burgess Diana J , King Heather A , Taylor Stephanie L , Martino Steve , Mayer John M , Wallace Robert B , Der-Martirosian Claudia , Kerns Robert D 
Published: April 2023

Abstract
The coronavirus disease (COVID-19) pandemic disrupted healthcare and clinical research, including a suite of 11 pragmatic clinical trials (PCTs), across clinics within the Department of Veterans Affairs (VA) and the Department of Defense (DOD). These PCTs were designed to evaluate an array of nonpharmacological treatments and models of care for treatment of patients with pain and co-occurring conditions.
The aims of the study are to (a) describe modifications to PCTs and interventions to address the evolving pandemic and (b) describe the application of implementation science methods for evaluation of those PCT modifications.
The project used a two-phase, sequential, mixed-methods design. In Phase I, we captured PCT disruptions and modifications via a Research Electronic Data Capture questionnaire, using Periodic Reflections methods as a guide. In Phase II, we utilized the Framework for Reporting Adaptations and Modifications-Expanded (FRAME) taxonomy to develop a focus group interview guide and checklist that would provide more in-depth data than Phase I. Data were analyzed using directed content analysis.
Phase I revealed that all PCTs made between two and six trial modifications. Phase II, FRAME-guided analyses showed that the key goals for modifying interventions were increasing treatment feasibility and decreasing patient exposure to COVID-19, while preserving intervention core elements. Context (format) modifications led eight PCTs to modify parts of the interventions for virtual delivery. Content modifications added elements to enhance patient safety; tailored interventions for virtual delivery (counseling, exercise, mindfulness); and modified interventions involving manual therapies.
Implementation science methods identified near-real-time disruptions and modifications to PCTs focused on pain management in veteran and military healthcare settings.
Worlds Apart: Does Perceptual Congruence Between Leaders and Older Employees Regarding Age-Friendly Organizational Climate, Management, and Work Design Matter?
Authors: Finsel Julia S , Venz Laura , Wöhrmann Anne M , Wilckens Max R , Deller Jürgen 
Published: April 2023

Abstract
Research on the effectiveness of age-friendly organizational practices tends to focus on older employees’ perceptions of these. Drawing on perceptual congruence and psychological contract theory, we hypothesize that leaders’ perceptions of these organizational practices are relevant as well. Specifically, we argue that (dis)agreement between leaders’ and older employees’ perceptions (i.e., perceptual (in)congruence) of organizational practices related to age-friendly organizational climate, management, and work design plays a role in older employees’ well-being. Polynomial regression and response surface analysis were applied to a dyadic sample of 484 older employees and their leaders from 100 diverse organizations. Results reveal that leader-employee perceptual congruence on high levels of perceived age-friendly work design was related to higher employee well-being. By contrast, older employees’ well-being was lower when leaders evaluated the three age-friendly organizational practices higher than their older employees. Our findings suggest that further theoretical consideration of the role of leader-employee perceptual (in)congruence for aging workforces is needed, and that scholars and organizations should acknowledge the relevance and interplay of different stakeholders’ perceptions within an organization.
Sensory Loss and its Association with Different Types of Departures from the Labor Force Among Older Adults in the US
Authors: Garcia Morales Emmanuel E , Powel Danielle S , Gray Andrew , Assi Lama , Reed Nicholas S 
Published: April 2023

Abstract
To investigate the association between sensory loss and the timing and type of self-reported departures from the labor force, via retirement or disability, we used data from the Health and Retirement Study, cycles 2004–2018. Based on self-reported sensory loss, we classified individuals into four groups: no sensory loss, hearing loss only, vision loss only, and dual sensory loss (vision and hearing loss). We assumed that older adults could leave the labor force either by retirement or due to disability. Because once one type of exit is observed the other type cannot be observed, we implemented a competing risk approach to estimate the instantaneous rate of departure (sub-distribution hazard rate) for leaving the labor force due to disability, treating retirement as a competing risk, and for departures via retirement, with disability as the competing risk. We found that compared to older adults with no sensory loss, adults with vision loss are at a higher risk for leaving the labor force via disability (when treating retirement as a competing risk). Compared to no sensory loss, hearing loss was associated with a higher risk for retirement in models treating disability as a competing risk. Given the differences between disability and retirement benefits (before and after retirement age), policies intended to keep people with sensory loss from early labor force departures, such as accommodations in the workplace and/or hearing and vision care coverage, might contribute to better retiring conditions and healthy aging among older adults with sensory loss.
Identification and characterization of a hepatic IL-13–producing ILC3-like population potentially involved in liver fibrosis
Authors: Raabe Jan , Kaiser Kim M. , ToVinh Michael , Finnemann Claudia , Lutz Philipp , Hoffmeister Christoph , Bischoff Jenny , Goeser Felix , Kaczmarek Dominik J. , Glowka Tim R. , Manekeller Steffen , Charpentier Arthur , Langhans Bettina , Nischalke Hans Dieter , Toma Marieta , Strassburg Christian P. , Spengler Ulrich , Abdallah Ali T. , Krämer Benjamin , Nattermann Jacob 
Published: April 2023

Background and Aims:
Human innate lymphoid cells (ILCs) are critically involved in the modulation of homeostatic and inflammatory processes in various tissues. However, only little is known about the composition of the intrahepatic ILC pool and its potential role in chronic liver disease. Here, we performed a detailed characterization of intrahepatic ILCs in both healthy and fibrotic livers.

Approach and Results:
A total of 50 livers (nonfibrotic = 22, and fibrotic = 29) were analyzed and compared with colon and tonsil tissue (each N = 14) and peripheral blood (N = 32). Human intrahepatic ILCs were characterized ex vivo and on stimulation using flow cytometry and single-cell RNA sequencing. ILC differentiation and plasticity were analyzed by both bulk and clonal expansion experiments. Finally, the effects of ILC-derived cytokines on primary human HSteCs were studied. Unexpectedly, we found that an “unconventional” ILC3-like cell represented the major IL-13-producing liver ILC subset. IL-13+ ILC3-like cells were specifically enriched in the human liver, and increased frequencies of this cell type were found in fibrotic livers. ILC3-derived IL-13 production induced upregulation of proinflammatory genes in HSteCs, indicating a potential role in the regulation of hepatic fibrogenesis. Finally, we identified KLRG1-expressing ILC precursors as the potential progenitor of hepatic IL-13+ ILC3-like cells.

Conclusions:
We identified a formerly undescribed subset of IL-13–producing ILC3-like cells that is enriched in the human liver and may be involved in the modulation of chronic liver disease.
Evaluation of serum vitamin D concentration and blood eosinophil and basophil counts in patients with vitiligo: cross-sectional study from Rafsanjan and Zarand, Iran
Authors: Taghizadeh Ghavamabadi Razieh , Pishgooie Reihaneh , Behfar Shadi , Taghavi Mohammad Mohsen , Babaee Abdolreza , Taghipour Zahra 
Published: April 2023

Objective:
Vitiligo is a chronic autoimmune depigmenting skin disorder. In this disease, the destruction of functional melanocytes can lead to reduced or absent pigmentation of the skin. Vitamin D deficiency has been reported in some autoimmune diseases. The association of eosinophils and basophils with autoimmune diseases has also been recently examined.

Methods:
The present study was performed to evaluate the serum vitamin D concentration and blood eosinophil and basophil counts in patients with vitiligo.

Results:
This descriptive cross-sectional study involved 30 patients with vitiligo. The average serum vitamin D concentration was significantly lower in the case group than in the control group (P = 0.01). Furthermore, the mean serum vitamin D concentration was significantly lower in women than in men (P = 0.03). The average eosinophil and basophil counts were not significantly different between the case and control groups.

Discussion:
The results of this study showed that the serum vitamin D concentration is low in patients with vitiligo. However, whether this reduction is a factor in the promotion of vitiligo or occurs after the onset of vitiligo remains unknown. Further studies on the serum vitamin D concentration in patients with vitiligo are needed to clarity this issue and develop effective treatments.
Association Between Rosacea and Frequent Changes in Moisturizing Products: A Multicenter Retrospective Case–control Survey
Authors: Jiang Yu-Meng , Yao Ya-Nan , Li Guo , Zheng Bo-Lan , Xie Hong-Fu , Li Ji , Huang Ying-Xue 
Published: April 2023

Objective:
To investigate the detailed relationship between frequent replacement of moisturizing product brands and the development of rosacea, with the overall goal of establishing guidelines for patients with rosacea.

Methods:
A multicenter retrospective case–control survey of 849 patients with rosacea and 980 controls with healthy skin was conducted using a standardized questionnaire. The questionnaire mainly included demographic data, the behavior of frequently changing moisturizing product brands, history of skin allergy or sensitivity symptoms within 2 years before rosacea onset for the patient group and within the most recent 2 years for the control group, current symptoms and signs, and self-reported symptoms. A comparative analysis was performed using the chi-square test and logistic regression analysis.

Results:
The behavior of frequently replacing moisturizing product brands was positively correlated with rosacea (P < 0.001, odds ratio [OR] = 1.522, 95% confidence interval [CI] = 1.148-2.018), and this correlation was more apparent in individuals with non-sensitive skin (P = 0.008, OR = 1.634, 95% CI = 1.135-2.352). With respect to different subtypes of rosacea, frequent replacement of moisturizing product brands was more likely to be associated with papulopustular rosacea (P = 0.003, OR = 1.804, 95% CI = 1.219-2.672) than with erythematotelangiectatic rosacea (P = 0.031, OR = 1.432, 95% CI = 1.033-1.984) compared with people who did not frequently replace their moisturizing product brands; however, these effects were not observed for phymatous rosacea (P > 0.05). We further investigated the clinical features of patients who frequently replaced their moisturizing products. Among invisible symptoms, these patients most often reported a stinging sensation (P = 0.007, OR = 1.497, 95% CI = 1.119-2.003), and among visible symptoms, telangiectasia was most common (P = 0.027, OR = 1.411, 95% CI = 1.041-1.913).

Conclusion:
Frequent replacement of moisturizing product brands was closely associated with the occurrence of rosacea. Our study provides useful information regarding skin care habits to the public and will help to promote the prevention and management of rosacea.
Epidemiology of depression and suicidal ideation in patients with psoriasis: A meta-analysis of prospective cohort studies
Authors: Yu Yi-Hui , Zhang San-Quan , Li Qian , Li Wei , Zhou Xin , Xue Ru-Jun , Liang Jing-Yao , Zhang Xi-Bao 
Published: April 2023

Background:
Psoriasis is an immune-mediated inflammatory, chronic, recurrent skin disease associated with a high risk of developing psychiatric disorders, especially depression and suicidal ideation, leading to functional disability and poor quality of life.

Objective:
To comprehensively review and assess the epidemiologic association between psoriasis and the risk ratios (RRs) of depression or suicidal ideation.

Methods:
Five databases (PubMed, Wanfang Database, CNKI, The Cochrane Library, and EMBASE) were searched for prospective cohort studies on the prevalence of depression and/or suicidal ideation in patients with psoriasis updated to 2 February 2023. Two independent reviewers evaluated and extracted the data, which were then pooled into a summary RR with corresponding 95% confidence interval (CI) using random-effects models in Stata/MP14.0.

Results:
Sixteen cohort studies comprising 1,166,840 patients with psoriasis and 3,294,205 controls were eligible for the final analysis. The pooled RR for depression was 1.43 (95% CI = 1.13–1.81) in patients with psoriasis and1.55 (95% CI = 1.40–1.71) in patients with psoriatic arthritis. In the subgroup analysis, Asian patients with psoriasis (RR=1.38, 95% CI =1.17–1.63) had a lower pooled RR for depression than non-Asian patients (RR=1.45, 95% CI = 1.07–1.97), and patients with moderate to severe psoriasis (RR=1.69, 95% CI = 1.15–2.50) showed a higher RR for depression than patients with mild psoriasis (RR=1.60, 95% CI= 1.06–2.42). We also found no increase in the RR for suicidal ideation among people with psoriasis (RR=1.25, 95% CI =0.95–1.65).

Conclusions:
Patients with psoriasis are at increased risk of depression. Among patients with psoriasis, those with psoriatic arthritis, those who are non-Asian, and those with moderate to severe psoriasis are at higher risk for depression. However, the available evidence does not support an association between psoriasis and suicidal ideation.
Oral Chinese medicines for treating diabetic macular edema: Protocol for a systematic search of randomized studies and meta-analysis
Authors: Gao Miaoran , Huang Sheng , Zhou Jian , Yang Yiqiu , Luo Xianke , Yang Changlu , Yu Xinning , Tang Mengdan , Yan Xiaoling 
Published: April 2023

AbstractIntroductionThe diabetic macular edema (DME) is a relevant cause of visual impairment in diabetes. The current treatments are limited by high costs, risk of infections and damage to retinal cells. Randomized controlled studies (RCTs) have investigated oral traditional Chinese medicines (TCMs) for the treatment of DME. We aimed at determining the efficacy and safety of oral TCMs by systematically reviewing the full set of studies.Methods and analysisPublished RCTs will be searched through 12 databases until October 1, 2022. Two investigators will conduct independent literature search, data extraction and assessment of quality. The risk of bias will be judged with the version 2 of the Cochrane risk-of-bias tool. The RevMan software will be utilized to analyze data. Dichotomous data will be assessed by using odds ratios and 95% confidence intervals (CIs). We will evaluate continuous data by using weighted mean differences and 95% CIs. We are going to assess heterogeneity by Cochran’s Q test and the I2statistics. We plan sensitivity analysis and subgroup analysis to identify sources of heterogeneity. Funnel plots, Egger’s tests and Begg’s tests will be also performed.Protocol registration numberThe study protocol is registered on PROSPERO (CRD42022379268).Strengths and limitationsThis is the first systematic study examining the efficacy and safety of orally administered Chinese medicines for DME.We will search randomized controlled trials in 12 databases.We will implement subgroup analysis and sensitivity analysis to explore any source of heterogeneity.The presence of several types of macular oedema might challenge the workload for this study.
Systematic mapping of chemoreceptor specificities forPseudomonas aeruginosa
Authors: Xu Wenhao , Cerna-Vargas Jean Paul , Tajuelo Ana , Montoya Andrea Lozano , Kivoloka Melissa , Krink Nicolas , Monteagudo-Cascales Elizabet , Matilla Miguel A. , Krell Tino , Sourjik Victor 
Published: April 2023

AbstractThe chemotaxis network, one of the most prominent prokaryotic sensory systems, is present in most motile bacteria and archaea. Although the conserved signaling core of the network is well characterized, ligand specificities of a large majority of diverse chemoreceptors encoded in bacterial genomes remain unknown. Here we performed a systematic identification and characterization of new chemoeffectors for the opportunistic pathogenPseudomonas aeruginosa, which has 26 chemoreceptors possessing most of the common types of ligand binding domains. By performing capillary chemotaxis assays for a library of growth-promoting compounds, we first identified a number of novel chemoattractants of varying strength. We subsequently mapped specificities of these ligands by performing Förster resonance energy transfer (FRET) and microfluidic measurements for hybrids containing ligand binding domains ofP. aeruginosachemoreceptors and the signaling domain of theEscherichia coliTar receptor. Direct binding of ligands to chemoreceptors was further confirmedin vitrousing thermal shift assay and microcalorimetry. Altogether, the combination of methods enabled us to assign several new attractants, including methyl 4-aminobutyrate, 5-aminovalerate, L-ornithine, 2-phenylethylamine and tyramine, to previously characterized chemoreceptors and to annotate a novel purine-specific receptor PctP. Our screening strategy could be applied for the systematic characterization of unknown sensory domains in a wide range of bacterial species.ImportanceChemotaxis of motile bacteria has multiple physiological functions. It enables bacteria to locate optimal ecological niches, mediates collective behaviors, and can play an important role in infection. These multiple functions largely depend on ligand specificities of chemoreceptors, and the number and identities of chemoreceptors show high diversity between organisms. Similar diversity is observed for the spectra of chemoeffectors, which include not only chemicals of high metabolic value but also bacterial, plant and animal signaling molecules. However, the systematic identification of chemoeffectors and their mapping to specific chemoreceptors remains a challenge. Here, we combined severalin vivoandin vitroapproaches to establish a systematic screening strategy for the identification of receptor ligands, and we applied it to identify a number of new physiologically relevant chemoeffectors for the important opportunistic human pathogenP. aeruginosa. This strategy can be equally applicable to map specificities of sensory domains from a wide variety of receptor types and bacteria.
Broad functional profiling of fission yeast proteins using phenomics and machine learning
Authors: Rodríguez-López María , Bordin Nicola , Lees Jon , Scholes Harry , Hassan Shaimaa , Saintain Quentin , Kamrad Stephan , Orengo Christine , Bähler Jürg 
Published: April 2023

AbstractMany proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches withSchizosaccharomyces pombefor broad cues on protein functions. We assayed colony-growth phenotypes to measure the fitness of deletion mutants for 3509 non-essential genes in 131 conditions with different nutrients, drugs, and stresses. These analyses exposed phenotypes for 3492 mutants, including 124 mutants of ‘priority unstudied’ proteins conserved in humans, providing varied functional clues. For example, over 900 proteins were newly implicated in the resistance to oxidative stress. Phenotype-correlation networks suggested roles for poorly characterized proteins through ‘guilt by association’ with known proteins. For complementary functional insights, we predicted Gene Ontology (GO) terms using machine learning methods exploiting protein-network and protein-homology data (NET-FF). We obtained 56,594 high-scoring GO predictions, of which 22,060 also featured high information content. Our phenotype-correlation data and NET-FF predictions showed a strong concordance with existing PomBase GO annotations and protein networks, with integrated analyses revealing 1,675 novel GO predictions for 783 genes, including 47 predictions for 23 priority unstudied proteins. Experimental validation identified new proteins involved in cellular ageing, showing that these predictions and phenomics data provide a rich resource to uncover new protein functions.
Antibacterial Activity ofAndrographis paniculataandPiper betleand their Interactive Effects with Amoxicillin Against Selected Respiratory Pathogens
Authors: Mejos Cristian B. , Poblete Joshua G. , Sarino Paula Jean C. , Cruzada Ma. Fatima I. 
Published: April 2023

ABSTRACTThis study was undertaken to determine the antibacterial activity and interactive effects of the methanol, ethanol and aqueous extract ofAndrographis paniculataandPiper betleleaves with amoxicillin against selected clinical isolates of respiratory pathogens:Escherichia coliUSTCMS 1030,Pseudomonas aeruginosa USTCMS10013, andStaphylococcus aureusUSTCMS 1097. Antibacterial activity of the plant extracts using disk diffusion showed that the methanol extract ofP. betleexhibited inhibitory activity against all the test organisms, whereas the methanol and ethanol extracts ofA. paniculataexhibited antibacterial activity toS. aureusUSTCMS 1097 only. The antimicrobial properties of each plant extract were further evaluated using broth microdilution. Results showed that the ethanol extract ofP. betlehad the most potent antibacterial activity against all test bacteria with minimum inhibitory concentrations of 6.5 mg/mL, 3.25 mg/mL, and 0.2 mg/mL forE. coliUSTCMS 1030,P. aeruginosaUSTCMS 10013 andS. aureusUSTCMS 1097, respectively. However, resazurin showed an inhibitory activity againstS. aureusUSTCMS 1097 in usual concentrations used in the assay, which is a novel finding since it is typically used as an indicator. Based on disk diffusion, the methanol and aqueous extracts ofP. betleshowed promising synergistic effect with the antibiotic amoxicillin. This was confirmed by checkerboard assay wherein the aqueous extract ofP. betleshowed an additive effect to amoxicillin againstE. coliUSTCMS 1030 (FICI = 0.66), while the methanol extract ofP. betleexhibited true synergism with amoxicillin againstP. aeruginosaUSTCMS 10013 (FICI = 0.33). This synergism between the ethanol extract ofP. betleand amoxicillin was significant since the activity of amoxicillin increased by 128-fold. This combination has potential in treating diseases associated with amoxicillin- resistantP. aeruginosa.