bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Belt and Road Initiative and Urban Entrepreneurship: Evidence From the Opening Policy From China
Authors: Xiong Ding , Zhong Xin , Sun Kai , Zhao Sirui 
Published: January 2025

ABSTRACTEntrepreneurship is a vital source of high‐quality employment in China and is crucial in advancing Chinese‐style modernization. Using panel data from 281 prefecture‐level cities in China from 2003 to 2021, this study employs difference‐in‐differences and double machine learning models to examine the impact of the Belt and Road Initiative (BRI) on entrepreneurship. The research findings are as follows: The BRI implementation significantly enhances entrepreneurship at city and provincial levels, with results remaining robust across various tests. The BRI promotes entrepreneurship through industrial innovation, digital trade development, and economic agglomeration. Heterogeneity analysis reveals that the BRI's positive effects on entrepreneurship are more pronounced in small and medium‐sized cities and central and western regions. Furthermore, the BRI exhibits significant spatial spillover effects, stimulating entrepreneurship in neighboring cities. The initiative also effectively reduces relative disparities in entrepreneurship across regions, particularly between eastern, central, and western areas, thus promoting coordinated regional development. Additionally, triple‐difference results indicate that the BRI's positive effects on urban industrial innovation are mainly concentrated in manufacturing sectors such as energy, equipment, and information technology. This study complements the BRI's effects and provides policy implications for narrowing regional entrepreneurship gaps and promoting high‐quality full employment in China.
LHPP‐P38 MAPK/ERK‐ETS1 Axis Negative Feedback Signaling Restrains Progression in Breast Cancer
Authors: Liu Xu , Yu Deyang , Yu Zhen , Su Sisi , Jiang Meixia , Zhao Chunbo 
Published: January 2025

ABSTRACTInvasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor‐suppressive effects, has an undefined role in BRCA. We found reduced LHPP protein in BRCA tissues, with lower levels correlating with poor patient outcomes. In vitro studies show LHPP inhibits BRCA cell proliferation, migration, invasion, and stemness. In vivo xenograft models support LHPP's role in curbing tumorigenesis and lung metastasis. Mechanistically, LHPP interacts with ERK and P38 MAPK, leading to their dephosphorylation and suppression of the MAPK pathway. We also reveal ETS1, a MAPK effector, repressing LHPP mRNA transcription, suggesting a LHPP‐P38 MAPK/ERK‐ETS1 negative feedback loop as a key regulatory mechanism in controlling BRCA invasion and metastasis.
Physiological condition drives ecological functions of two highly abundant and widespread dung beetles of South American pasturelands
Authors: Correa César M. A. , de Oliveira Pedro Lucas Moreira , de Cerqueira Leonardo Vilas‐Boas M. P. , González‐Tokman Daniel , Abot Alfredo R. , Salomão Renato Portela 
Published: January 2025

Abstract
Physiological condition plays a pivotal role on the interaction between individuals and the environment, consequently being related to the ecological functions that organisms provide. Body dry mass, fat and muscle mass have been proved to affect the way in which organisms behave, as the depletion of nutrients in their body affect the strategies that they present.
In this study, we used two dung beetle species as a model to test the effects of individual traits and physiological condition on the ecosystem services provided by them (e.g., dung removal and soil excavation). To attain this goal, we used Dichotomius nisus and D. bos, which are widespread species that inhabit South American pasturelands and are considered important for the ecosystem functioning of these regions.
The beetles were collected from introduced pastures (Urochloa spp.) in the Brazilian Cerrado biome, and the functions performed by the individuals were evaluated in the laboratory, with females and males in buckets filled with soil.
Our results show that individuals with higher amounts of fat mass performed less ecosystem functions. Furthermore, dung beetles with more muscle removed more dung and soil during their activities. Lastly, these patterns were sex and species dependent.
Our study provides evidence that individual physiological condition affects ecological functions provided by dung beetles. Thus, the integration of animal condition may allow a deeper understanding of the physiological basis of the ecosystem services provided by dung beetles, as well as an individual perspective on the contribution of their ecological services.
Hematologic Complications of Pregnancy
Authors: Patel Payal Bharatkumar , Patel Nidhi , Hedges Madeline A. , Benson Ashley E. , Tomer Arjun , Lo Jamie O. , Shatzel Joseph J. 
Published: January 2025

ABSTRACTHematologic complications are common in pregnancy and can significantly impact both maternal and fetal health. Recognizing and treating these complications can be challenging due to the limited evidence available to guide clinical consultants. Iron deficiency anemia is the most prevalent hematologic issue in pregnancy and often occurs due to increased maternal blood volume and the nutritional demands of the growing fetus. Thrombocytopenia is the second most commonly occurring hematologic issue in pregnancy and can be associated with increased blood loss and complications during childbirth. However, the most common type of thrombocytopenia in pregnancy is gestational thrombocytopenia, which does not typically require clinical management. Thus, it is important to distinguish gestational thrombocytopenia from other etiologies of thrombocytopenia in pregnancy that require immediate treatment, including immune thrombocytopenia, thrombotic thrombocytopenic purpura, preeclampsia, and HELLP (hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome. Other important hematologic conditions in pregnancy include non‐inherited anemias, such as autoimmune hemolytic anemia and aplastic anemia, as well as inherited anemias, such as sickle cell disease and thalassemia, which may require specialized management to optimize maternal and fetal outcomes. Additionally, bleeding disorders, such as von Willebrand disease and hemophilia, pose unique challenges in pregnancy, especially around the time of delivery, due to the risk of excessive bleeding. Lastly, thromboembolic disorders, such as venous thromboembolism (VTE), remain the leading cause of mortality in pregnancy in developed countries. Pregnancy‐related hormonal changes, venous stasis, and hypercoagulability contribute to an increased thromboembolic risk, further exacerbated by additional risk factors such as obesity or a prior personal or family history of VTE. This review aims to summarize current guidelines and management of the most common hematologic disorders in pregnancy.
Machine Learning Algorithms to Address the Polarity and Stigma of Mental Health Disclosures on Instagram
Authors: Merayo Noemí , Ayuso‐Lanchares Alba , González‐Sanguino Clara 
Published: January 2025

ABSTRACTThis research explores the social response to disclosures and conversations about mental health on social media, which is a pioneering and innovative approach. Unlike previous studies, which focused predominantly on psychopathological aspects, this study explores how communities react to conversations about mental health on Instagram, one of the favourite social media platforms among young people, breaking new ground not only in the Spanish context, but also on a global scale, filling a gap in international research. The study created a novel corpus by collecting and labelling comments on Instagram posts related to celebrity mental health disclosures, categorising them by polarity (positive, negative, neutral) and stigma. Additionally, the research implements machine learning algorithms to detect stigma and polarity in mental health disclosures on Instagram. While traditional techniques like Support Vector Machine (SVM) and RF (Random Forest) displayed decent performance with lower computational loads, advanced deep learning and BERT (Bidirectional Encoder Representation from Transformers) algorithms achieved outstanding results. In fact, BERT models achieve around 96% accuracy in polarity and stigma detection, while deep learning models achieve 80% for polarity and 87% for stigma, very high accuracy metrics. This research contributes significantly to understanding the impact of mental health discussions on social media, offering insights that can reduce stigma and raise awareness. Artificial intelligence can be used for more responsible use of social media and effective management of mental health problems in digital environments.
Ethnic Inequity in the Current Approach to H. pylori Testing and Treatment: Linked Data Cohort Analysis
Authors: Teng Andrea , Hildred Erin , Stanley James , Inns Stephen , McLeod Melissa 
Published: January 2025

ABSTRACTBackgroundAs seen globally, there are up to sixfold differences in gastric cancer mortality by ethnicity in Aotearoa New Zealand, and H. pylori is the major modifiable risk factor. This study investigates whether current H. pylori testing and treatment approaches are equitable.Materials and MethodsThe study design was a retrospective cohort analysis of linked administrative health data. Laboratory testing data and pharmacy dispensing were linked to the Northern region health user population dataset (1.9 million) from 2015 to 2018. We investigated an individual's first test for H. pylori. Regression analyses compared ethnic differences in rates of H. pylori testing, infection, treatment, and retesting, adjusted for age, sex, and calendar year.ResultsEthnic inequities were present across the clinical pathway. Compared to sole‐European, testing rates were lowest in Māori (OR 0.69) and Pacific (OR 0.81) and highest in Middle‐Eastern/Latin‐American/African (MELAA) (OR 2.21) and Asian (OR 2.02). Positivity rates were highest in MELAA (RR 2.96, 39%) and Pacific (RR 2.84, 38%) followed by Asian (RR 1.93, 26%) and Māori (RR 1.71, 23%). Treatment rates were similar for Asian (HR 1.05), MELAA (HR 1.03), and Māori (HR 0.98) compared to sole‐European but lower in Pacific (HR 0.90). Māori and Pacific were half as likely to be retested as sole‐European.ConclusionsDespite the higher prevalence of H. pylori and gastric cancer, Māori and Pacific are relatively underserved with lower rates of testing and treatment than sole‐European. Improved guidelines and the consistent application of these along with an equity‐focused test and treat program are likely to be particularly beneficial for Māori and Pacific in addressing inequities.
Liver‐to‐spleen ratio obtained from gadoxetate disodium‐enhanced magnetic resonance imaging predicts intrahepatic recurrence after curative resection of hepatocellular carcinoma
Authors: Notake Tsuyoshi , Shimizu Akira , Kubota Koji , Kitagawa Noriyuki , Sugenoya Shinsuke , Yoshizawa Takahiro , Sakai Hiroki , Hayashi Hikaru , Tomida Hidenori , Yamazaki Shiori , Hayashi Shigeki , Yamada Akira , Fujinaga Yasunari , Soejima Yuji 
Published: January 2025

AbstractAimThe purpose of this study was to evaluate whether parameters obtained from gadoxetate disodium‐enhanced magnetic resonance imaging (EOB‐MRI) could predict intrahepatic tumor recurrence in patients who underwent curative hepatectomy for hepatocellular carcinoma (HCC).MethodsThis study included 208 patients who underwent EOB‐MRI before hepatectomy for HCC. The mean signal intensity of the liver (L20) and spleen (S20) was obtained from preoperative EOB‐MRI, and liver‐to‐spleen ratio (LSR) was calculated from these values as: LSR = L20/S20. The association of LSR value with intrahepatic recurrence of HCC after curative hepatectomy was analyzed.ResultsIntrahepatic recurrence in the remnant liver developed in 111 (53%) patients during the median follow‐up period of 52.0 (range, 7.0–134.9) months after hepatectomy. Cumulative incidence of intrahepatic recurrence was significantly higher in patients with low LSR (<2.0) than in those with high LSR (≥2.0) (p < 0.001). In multivariable analysis, low LSR was identified as an independent predictor of intrahepatic recurrence (hazard ratio, 1.83; 95% confidence interval [CI], 1.23–2.72; p = 0.002), together with multiple tumors, macroscopic vascular invasion, and high‐grade fibrosis of the background liver. Subgroup analysis according to the time of recurrence (within 1 year or more) revealed that low LSR was significantly associated with late recurrence (hazard ratio, 2.35; 95% CI, 1.40–3.94; p = 0.001), but not with early recurrence.ConclusionsLow LSR was an independent risk factor of intrahepatic recurrence after curative hepatectomy for HCC, and was especially associated with late recurrence developing more than 1 year after curative hepatectomy.
In vivo efficacy of a stabilized Vitamin C‐based serum at pH 6 on some ageing facial signs of women of different ages and phototypes
Authors: Isoir‐Ingrez Muriel , Veriato Anna , Figueiredo Sara , Cornillon Céline , Hassler Sandra , Wang Pamella H. , Simonnet Jean‐Thierry 
Published: January 2025

AbstractObjectiveTo assess, clinically and instrumentally, the efficacy of a stabilized 12% Vitamin C (VC)‐based serum (pH 6) on skin photoageing of women of various age and phototype.Materials and MethodsEighty women, with Phototypes I to VI, of various age (45–70y) living in Mauritius, participated in an open, uncontrolled study. After a two‐week period of washout, they applied the Vitamin C‐based serum twice a day for 2 months onto their whole face as well as a hydrating cream every evening to ensure a comparable skin hydration level in all subjects. At set time intervals (D0, D immediate, D14, D28 and D56), a local dermatologist graded eight facial signs by visual or tactile assessments, using a 0–9 structured scale. At each time interval, the facial skin was imaged by standardized technique (Colorface™) and through echography (Dermascan™) to record its thickness and density. Skin elasticity was recorded by a the Cutometer® device under a controlled suctional stress. A questionnaire was filled out by all subjects recording their self‐assessments of the serum's effects and several organoleptic properties.ResultsCompared with the baseline values (D0), the skin of all subjects showed progressive and significant changes in glow, tone evenness, radiance, firmness, softness and smoothness, associated with a reduction in fine lines. Deep wrinkles, only observed on 26 subjects, were found to be reduced. Self‐assessments corresponded well with both clinical and instrumental results and indicated excellent skin tolerance. Ultrasound recordings exhibited significantly thicker and denser skin at D56.ConclusionIf certain changes in some skin facial signs (skin tone and related items, firmness, sagging…) are linked to the high concentration of VC, a complementary impact of increased skin hydration remains possible due to the glycerol present in the serum and hydrating cream. These significant performance results in vivo showed that a very acidic medium (∼pH 3) is not a prerequisite to an efficient VC cosmetic formula, as has long been accepted in the cosmetics industry. Such a low pH can fragilize the skin equilibrium over time. As second originality, the studied formula seemed to fit all phototypes.
Clinical efficacy of OS‐01 peptide formulation in reducing the signs of periorbital skin aging
Authors: Zonari Alessandra , Brace Lear E. , Li Fanghua , Harder Nathaniel H. O. , Harker Claire , Jacob Carolyn , Kaufman Joely , Chilukuri Suneel , Oliveira Carolina R. , Boroni Mariana , Carvalho Juliana L. 
Published: January 2025

AbstractBackgroundThe aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.ObjectiveThis study investigates the efficacy of a novel topical formulation, OS‐01 EYE, containing the senomorphic peptide, OS‐01, along with other active ingredients, in improving the skin around the eyes.MethodsA 12‐week clinical study was conducted with 22 participants who applied OS‐01 EYE twice daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under‐eye puffiness, and dark circles.ResultsAfter 12 weeks of product use, transepidermal water loss (TEWL) decreased by 17.33%, hydration increased by 32.49%, skin firmness improved by 10.19%, and elasticity increased by 25.58%, compared to baseline, which was all statistically significant. Expert grading revealed a decrease in fine lines and wrinkles, under‐eye puffiness, and dark circles over the study period. Furthermore, subjective assessments showed that 95.46% of participants reported improvements in overall appearance.ConclusionThe OS‐01 EYE formulation was found to be safe and effective in mitigating the visible signs of aging in the periorbital region, making it a potent treatment option for enhancing periorbital skin health, function, and appearance.
Development of (W,Ti,Ta)C/CaF2 nano‐self‐lubricating cermet tool and its dual lubrication cutting mechanism
Authors: Yi Mingdong , Zhao Long , Zhang Zhihui , Yu Yansong , Bao Yunchu , Wang Jiaxiang , Shan Ting , Zhang Jingjie , Chen Hui , Chen Zhaoqiang , Xiao Guangchun , Xu Chonghai 
Published: January 2025

AbstractA (W,Ti,Ta)C/CaF2 nano‐self‐lubricating cermet tool was prepared by spark plasma coupling high‐frequency induction sintering (SP–HF sintering) process. Under the optimal sintering parameters, nano CaF2 was uniformly distributed within the matrix grain, forming an intragranular nanostructure. When the content of nano CaF2 is 5 vol.%, the flexural strength, hardness, and fracture toughness of (W,Ti,Ta)C/CaF2 nano‐self‐lubricating cermet tool were 1134 ± 28 MPa, 18.97 ± 0.22 GPa, and 8.52 ± 0.16 MPa·m1/2, respectively. The antifriction mechanism in turning of Cr12 steel was studied with nano solid lubricating technology and minimum quantity lubrication (MQL) technology. The results showed that nano CaF2 diffused into the internal friction zone during the cutting process to form a lubricating film, and the MQL technology provided a lubrication effect in the external friction zone. The combination of solid lubrication and minimum quantity lubrication reduced the cutting force, cutting temperature, metamorphic layer thickness, and oxidation degree. The dual lubrication mode significantly improved the wear resistance of the tool. Under the conditions of cutting speed vc = 300 m/min, back engagement ap = 0.15 m/min, and feed rate f = 0.102 mm/r, the tool life was about 15 000 m, and the stable wear stage was effectively extended. The surface roughness of the workpiece within the effective cutting distance was about 0.630 µm.
Prenatal exposure to particulates and anthropometry through 9 years of age in a birth cohort
Authors: Trees Ian R. , Saha Abhisek , Putnick Diane L. , Clayton Priscilla K. , Mendola Pauline , Sundaram Rajeshwari , Yeung Edwina H. 
Published: January 2025

SummaryBackgroundPrevious research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied. Aim: We examined prenatal particulate matter (PM10, PM2.5) exposure and child anthropometry.Materials & MethodsChildren's body mass index z‐scores (zBMI) at 0–3 (N = 4370) and 7–9 (n = 1191) years were derived from reported anthropometry at paediatric visits. We ran linear mixed models for six windows, adjusting for maternal, child, and neighbourhood factors.ResultsPM10 exposure across pregnancy and at multiple windows was associated with higher zBMI in both early and middle childhood. For instance, one interquartile range increase in PM10 exposure during the first 2 weeks of pregnancy was associated with higher zBMI at 0–3 (0.05, 95% CI: 0.01, 0.10) and 7–9 (0.14, 95% CI: 0.02, 0.23). PM2.5 exposure during the final 2 weeks of gestation was associated with higher zBMI at 7–9 years (B: 0.12, 95% CI: 0.04, 0.22).ConclusionEven at low levels of air pollution, prenatal PM10 exposure was associated with higher zBMI in childhood.
CEOs With a Financial Background and Corporate Risk‐Taking
Authors: Wei Dianlong , Luo Chunhua , Lu Jinjing 
Published: January 2025

ABSTRACTThis study assesses the effect of CEOs' financial background characteristics on corporate risk‐taking. Although previous studies have extensively examined how CEOs' financial background characteristics influence firm behavior, few have focused on their effects on corporate risk‐taking. Using a sample of 26,084 firm‐year observations of 3468 listed firms in China between 2008 and 2020, we examine whether CEOs' background characteristics, particularly having a financial background, affect corporate risk‐taking. We find that a CEO with a financial background tends to adopt higher levels of corporate risk‐taking. Moreover, our findings suggest that these CEOs increase corporate risk‐taking by alleviating financing constraints, fostering the integration of industrial and financial capital, and promoting the financialization of enterprises. Overall, our findings contribute to the literature on the relationship between executives' financial backgrounds and corporate risk‐taking by offering insights from the perspective of CEOs' experience. These results have important implications for firms in terms of executive selection, management team optimization, and fostering greater integration between industry and finance.
Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution
Authors: Vacher Claire‐Marie , Tsompanidis Alex , Firestein Morgan R. , Penn Anna A. 
Published: January 2025

AbstractThe placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta‐brain axis and the links between placental function and brain development represents an emerging research area dubbed “neuroplacentology.” The placenta drives many circulating fetal steroids to very high levels during gestation. Recent studies have highlighted the critical role of placental steroids in shaping specific brain structures and behaviors. This review uses a cross‐species framework to discuss the genomic factors, in‐utero environmental changes, and placental conditions that alter placental steroidogenesis, leading to changes in early developmental trajectories relevant for psychiatric conditions such as autism, in a sex‐linked manner.