bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of subclinical left ventricular systolic dysfunction in patients with asymptomatic severe aortic stenosis with preserved left ventricular systolic function by three‐dimensional speckle tracking echocardiography
Authors: Nahar Nurun , Haque Tuhin , kabiruzzaman Mohammad , Khan Mohammad Abdul Mazid , Choudhury Sohel Reza , Malik Fazila‐tun‐nesa 
Published: July 2023

AbstractObjectivesLeft ventricular dysfunction and remodeling can occur as a result of aortic valve stenosis (AS). Three‐dimensional speckle tracking echocardiography (3D‐STE) can detect early left ventricular myocardial dysfunction even before ejection fraction declines. The purpose of this study was to look at the relationship between various myocardial strain parameters measured by 3D‐STE in asymptomatic severe AS patients from Bangladesh.MethodsThis study included 46 patients with asymptomatic severe AS but preserved LV systolic function (mean age 50.11 ± 12.66 years, LVEF 63.78 ± 3.95%, AS group) and 33 healthy subjects with no cardiovascular disease (mean age 48.21 ± 4.53 years, LVEF 65.15 ± 3.13%, control group). 3D‐STE was used to measure left ventricular global myocardial strain parameters such as peak systolic longitudinal strain (PSLS), circumferential strain, radial strain, and area strain.ResultsThe AS group had significantly thicker interventricular septum and posterior ventricular wall than the control group (1.49 ± .19 cm vs. .81 ± .09 cm, p < .001; 1.73 ± 1.71 cm vs. .81 ± .10 cm, p = .003, respectively.) In the AS group, the Indexed Aortic Valve Area (AVA) was significantly lower than in the control group. (.29 ± .10 vs. 2.03 ± .18, p < .001, respectively). In terms of LVEF (p = .102), left ventricular end diastolic volume (p = .075), or left ventricular end systolic volume (p = .092), no significant inter‐group difference was found. However, global PSLS (−10.75 ± 2.27 vs. −16.42 ± 2.76, p < .001), circumferential strain (−14.26 ± 3.40 vs. −16.64 ± 2.56, p = .001), area strain (−22.70 ± 4.19 vs. −26.45 ± 9.90, p = .024) and radial strain (32.20 ± 8.77 vs. 41.00 ± 7.52, p < .001) in the AS group were significantly lower than in the control group.ConclusionOur findings showed reductions in left ventricular global myocardial strains, particularly PSLS in patients suffering from asymptomatic severe AS in Bangladesh; this is consistent with other studies. Reduced area strain, detectable with 3D‐STE, is also consistent with that pattern.
Catches of Euxoa tritici in pheromone traps for Anarsia lineatella are due to the presence of (Z)‐5‐decenyl acetate as an impurity
Authors: Nagy Antal , Szarukán István , Bohman Björn , Szanyi Szabolcs , Kozák Lajos , Szilágyi Arnold , Imrei Zoltán , Vuts József , Matula Eszter , Varga Zoltán , Tóth Miklós 
Published: July 2023

AbstractTraps baited with the synthetic pheromone of Anarsia lineatella Zeller (Lepidoptera: Gelechiidae) frequently captured also Euxoa tritici L. males (Lepidoptera: Noctuidae) in field tests in Hungary. As (E)‐monounsaturated compounds are uncommon among sex attractants or pheromone components of Noctuidae, it was hypothesized that the Euxoa catches may have been due to impurities of the (Z) isomer in synthetic (E)‐5‐decenyl acetate, which is the major component in the pheromone lure of A. lineatella. Traps baited with synthetic (Z)‐5‐decenyl acetate captured large numbers of E. tritici, and the compound showed a clear dose–response effect. Reanalysis of the synthetic batch of (E)‐5‐decenyl acetate used in preparation of the A. lineatella lure showed the presence of 10% of the (Z) isomer. Traps baited with synthetic (Z)‐5‐decenyl acetate can be used in the future for detection and monitoring purposes of E. tritici, a widely distributed pest of cereals and other field crops. The compound also showed attraction of Euxoa seliginis Duponchel.
Inflammation biomarkers in acute ischemic stroke according to different etiologies
Authors: Meisinger Christa , Freuer Dennis , Schmitz Timo , Ertl Michael , Zickler Philipp , Naumann Markus , Linseisen Jakob 
Published: July 2023

AbstractBackgroundHigh throughput technologies provide new opportunities to further investigate the pathophysiology of ischemic strokes. The present cross‐sectional study aimed to evaluate potential associations between the etiologic subtypes of ischemic stroke and blood‐based proteins.MethodsWe investigated the associations between ischemic stroke subtypes and a panel of circulating inflammation biomarkers in 364 patients included in the Stroke Cohort Augsburg (SCHANA). Stroke etiologies were categorized according to the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification. Serum concentrations of 52 biomarkers were measured using the Bio‐Plex Pro™ Human Cytokine Screening Panel, ICAM‐1 set and VCAM‐1 set, plus the Pro™ Human TH17 cytokine sCD40L set and IL31 set (all Bio‐Rad, USA). Multivariable linear regression models were used to examine associations. Point estimates were calculated as the mean difference in ‐standardized cytokine levels on the log2‐scale.ResultsStromal‐cell‐derived‐factor 1 alpha (SDF‐1a) showed significantly higher serum levels in cardioembolic compared with large vessel atherosclerotic stroke (β = 0.48; 95% CI 0.22; 0.75; Padj = 0.036). Significantly lower levels of interleukin‐6 (IL‐6) (β = −0.53; 95% CI −0.84; −0.23; Padj = 0.036) and macrophage migration inhibitory factor (MIF) (β = −0.52; 95% CI −0.84; −0.21; Padj = 0.043) were found in the small vessel versus large vessel stroke subtype.ConclusionsImmune dysregulations observed in different stroke subtypes might help uncover pathophysiological mechanisms of the disease. Further studies are needed to validate identified biomarkers in diverse study populations before they can potentially be used in clinical practice to further improve stroke management and patient outcomes.
Statistical guidance provided to authors by clinical neurology and neuroscience journals
Authors: Tumma Sanjana , Sonneborn Claire , Padate Aishwarya , Hogue Olivia 
Published: July 2023

AbstractBackground and purposeTransparent reporting and appropriate interpretation of statistical methods and results are important to facilitate scientific evaluation and enable future replication. The goal of this study was to describe statistical reporting guidance provided to authors by clinical neurology and neuroscience journals.MethodsFor first‐quartile journals in each discipline (per Clarivate InCites), information collected from Instructions to Authors website sections included whether journals required presentation of sample size justification, estimates of precision, and method of checking assumptions; and guidance for interpretation of p‐values and appropriate presentation of descriptive statistics and graphs. Journal endorsement of common but statistically nonspecific published transparent reporting guidelines for human and animal research was also collected, to capture the select statistical reporting items included in each guideline.ResultsJournals (n = 85) frequently did not require/recommend sample size justifications (15% not required; 62% only required per external transparent reporting guideline), estimates of precision (15% not required; 41% only required per external guidelines), or disclosure of method of checking assumptions (46%); nor provide guidance for reporting/interpretation of p‐values (71%), reporting of descriptive statistics (75%), or use of appropriate graphs (92%). Endorsement of statistically nonspecific standalone reporting guidelines ranged between 52% and 68%, depending on the guideline.ConclusionsThere is opportunity for journals to facilitate improvement in transparency of statistical methods and results for clinical neurology and neuroscience studies by providing guidelines and advice to authors at manuscript submission.
Partner‐seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster)
Authors: Vitale Erika M. , Kirckof Adrianna , Smith Adam S. 
Published: July 2023

AbstractDeath of a loved one is recognized as one of life's greatest stresses, and 10%–20% of bereaved individuals will experience a complicated or prolonged grieving period that is characterized by intense yearning for the deceased. The monogamous prairie vole (Microtus ochrogaster) is a rodent species that forms pair bonds between breeding partners and has been used to study the neurobiology of social behaviors and isolation. Male prairie voles do not display distress after isolation from a familiar, same‐sex conspecific; however, separation from a bonded female partner increases emotional, stress‐related, and proximity‐seeking behaviors. Here, we tested the investigatory response of male voles to partner odor during a period of social loss. We found that males who lost their partner spent significantly more time investigating partner odor but not non‐partner social odor or food odor. Bachelor males and males in intact pairings did not respond uniquely to any odor. Furthermore, we examined dopamine (DA) receptor mRNA expression in the anterior insula cortex (aIC), nucleus accumbens (NAc), and anterior cingulate (ACC), regions with higher activation in grieving humans. While we found some effects of relationship type on DRD1 and DRD2 expression in some of these regions, loss of a high‐quality opposite‐sex relationship had a significant effect on DA receptor expression, with pair‐bonded/loss males having higher expression in the aIC and ACC compared with pair‐bonded/intact and nonbonded/loss males. Together, these data suggest that both relationship type and relationship quality affect reunion‐seeking behavior and motivational neurocircuits following social loss of a bonded partner.
Harnessing the conditioned pain modulation response in migraine diagnosis, outcome prediction, and treatment—A narrative review
Authors: Nahman‐Averbuch Hadas , Callahan David , Darken Rachel , Haroutounian Simon 
Published: July 2023

AbstractObjectiveTo present the potential use and relevance of the conditioned pain modulation (CPM) response to migraine diagnosis, outcome prediction, and treatment.BackgroundThe CPM response is a widely used laboratory test to examine inhibitory pain modulation capabilities.MethodsThis narrative review summarizes and synthesizes the findings on the CPM response in patients with migraine.ResultsFor diagnosis, we summarized the studies comparing CPM responses between patients with migraine and individuals without migraine or with other headache syndromes, as well as between patients with subtypes of migraine. For prediction, we summarized the studies utilizing the CPM response to predict migraine outcome, such as response to interventions. For treatment, we described a device that utilizes the CPM response for acute and preventative migraine treatment. In addition, we suggest the requirements needed for the CPM response to be used for migraine diagnosis, outcome prediction, and treatment.ConclusionsAlthough more research is needed, the CPM response could be a useful tool for improving migraine management.
Antecedents and outcomes of work engagement among nursing staff in long‐term care facilities—A systematic review
Authors: Midje Hilde Hovda , Nyborg Vibeke Narverud , Nordsteien Anita , Øvergård Kjell Ivar , Brembo Espen Andreas , Torp Steffen 
Published: July 2023

AbstractAimTo determine antecedents and outcomes of work engagement (WE) among nursing staff in long‐term care (LTC) using the Job Demand‐Resources model.DesignA systematic review following the Preferred Reporting Items for Systematic Review and Meta‐Analysis statement and Synthesis Without Meta‐analysis in systematic reviews guideline. A study protocol was registered in PROSPERO (registration number CRD42022336736).Data SourcesThe initial searches were performed in PsycInfo, Medline, Academic Search Premier, CINAHL and Scopus and yielded 3050 unique publications. Updated searches identified another 335 publications. Sixteen studies published from 2010 to 2022 were included.Review MethodsThe screening of titles and abstracts, and subsequently full‐text publications, was performed blinded by two author teams using the inclusion/exclusion criteria. When needed, a mutual consensus was obtained through discussion within and across the teams. A descriptive and narrative synthesis without a meta‐analysis of the included studies was performed.ResultsThe extent of research on WE in LTC facilities is limited and the factors examined are heterogeneous. Of forty‐two unique antecedents and outcomes, only three factors were assessed in three or more studies. Antecedents—in particular job resources—are more commonly examined than outcomes.ConclusionExisting literature offers scant evidence on antecedents and outcomes of WE among nursing staff in LTC facilities. Social support, learning and development opportunities and person‐centred processes are the most examined factors, yet with ambiguous results.ImpactAntecedents and outcomes of engagement among nursing staff in LTC facilities have not previously been reviewed systematically. Engagement has been correlated with both more efficient and higher‐quality service delivery. Our findings suggest opportunities to improve health and care services by enhancing engagement, whilst at the same time better caring for employees. This study lays the groundwork for more detailed research into the contributing factors and potential results of increasing caregivers' engagement.No patient or public contribution.
Local recurrence risk of esophageal squamous cell carcinoma due to intralesional damage during endoscopic submucosal dissection
Authors: Minamide Tatsunori , Kawata Noboru , Maeda Yuki , Yoshida Masao , Yamamoto Yoichi , Ashizawa Hiroshi , Takada Kazunori , Kishida Yoshihiro , Ito Sayo , Imai Kenichiro , Hotta Kinichi , Sato Junya , Ishiwatari Hirotoshi , Matsubayashi Hiroyuki , Sugino Takashi , Ono Hiroyuki 
Published: July 2023

AbstractBackground and AimIt is unclear whether additional treatment should be considered given the recurrence risk after endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) when the vertical margin is positive or unclear (VM1/VMX) due to intralesional damage. This study aimed to elucidate the local recurrence risk of ESCC caused by intralesional damage during ESD.MethodsAmong consecutive patients with pT1a ESCCs initially treated by ESD at our institution between January 2006 and December 2018, ESCCs diagnosed as VM1/VMX were retrospectively reviewed. Exclusion criteria were piecemeal resection and any additional treatment after ESD. Intralesional damage included the following three types: a macroscopic hole inside the lesion, an incision from the lateral margin of the specimen into the lesion, and crushing injury or burn effect into the deepest area of the lesion without an obvious hole. The local recurrence rate after ESD was primarily analyzed.ResultsOf 1174 pT1a ESCCs initially treated using ESD, 22 lesions were histopathologically diagnosed as VM1/VMX due to intralesional damage (1.9%; 95% confidence interval [CI], 1.2–2.8%). At a median follow‐up period of 60.0 (interquartile range, 15.0–84.0) months, no local recurrence was observed (0.0%; 95% CI, 0.0–13.3%) among 21 lesions finally evaluated.ConclusionsThe impact of intralesional damage during ESD for ESCC on local recurrence might be negligible. Follow‐up without additional treatment may be acceptable even if intralesional damage occurs and results in VM1/VMX after ESD for pT1a ESCCs.
Does the Government Spending Multiplier Depend on the Business Cycle?
Authors: LAUMER SEBASTIAN , PHILIPPS COLLIN 
Published: July 2023

AbstractWe investigate the state dependency of the government spending multiplier across the business cycle using a nonlinear two‐regime VAR model. We find little evidence that multipliers vary between expansionary and recessionary periods. This is because the state of the business cycle itself changes after government spending shocks and converges toward a similar state. This result holds true regardless of how we model the business cycle. Our analysis shows that assumptions about the economic state built into linear impulse response functions are the key driver of the state dependency reported elsewhere in the literature.
Identifying genetic loci that are associated with changes in gene expression in PTSD in a South African cohort
Authors: Swart Patricia C. , Du Plessis Morne , Rust Carlien , Womersley Jacqueline S. , van den Heuvel Leigh L. , Seedat Soraya , Hemmings Sian M. J. 
Published: July 2023

AbstractThe molecular mechanisms underlying posttraumatic stress disorder (PTSD) are yet to be fully elucidated, especially in underrepresented population groups. Expression quantitative trait loci (eQTLs) are DNA sequence variants that influence gene expression, in a local (cis‐) or distal (trans‐) manner, and subsequently impact cellular, tissue, and system physiology. This study aims to identify genetic loci associated with gene expression changes in a South African PTSD cohort. Genome‐wide genotype and RNA‐sequencing data were obtained from 32 trauma‐exposed controls and 35 PTSD cases of mixed‐ancestry, as part of the SHARED ROOTS project. The first approach utilised 108 937 single‐nucleotide polymorphisms (SNPs) (MAF > 10%) and 11 312 genes with Matrix eQTL to map potential eQTLs, while controlling for covariates as appropriate. The second analysis was focused on 5638 SNPs related to a previously calculated PTSD polygenic risk score for this cohort. SNP‐gene pairs were considered eQTLs if they surpassed Bonferroni correction and had a false discovery rate <0.05. We did not identify eQTLs that significantly influenced gene expression in a PTSD‐dependent manner. However, several known cis‐eQTLs, independent of PTSD diagnosis, were observed. rs8521 (C > T) was associated with TAGLN and SIDT2 expression, and rs11085906 (C > T) was associated with ZNF333 expression. This exploratory study provides insight into the molecular mechanisms associated with PTSD in a non‐European, admixed sample population. This study was limited by the cross‐sectional design and insufficient statistical power. Overall, this study should encourage further multi‐omics approaches towards investigating PTSD in diverse populations.image
Repeated transvaginal natural orifice transluminal endoscopic surgery: An initial Chinese experience
Authors: Feng Dan , Liu Tianjiao , Li Xin , Peng Jieru , Huang Lu , He Li 
Published: July 2023

AbstractAimsTo investigate the perioperative outcomes and sexual function of patients undergoing repeated transvaginal natural orifice transluminal endoscopic surgery (vNOTES).MethodsWe retrieved the records of patients who underwent vNOTES twice at our institute between April 2019 and December 2022 and analyzed their baseline information and perioperative complications, and compared the pre‐ and postoperative sexual function of both vNOTES.ResultsPatients' mean age and body mass index were 29.00 ± 3.59 and 30.4 ± 4.00 years and 21.89 ± 3.69 and 22.76 ± 3.88 kg/m2, respectively, when receiving the first and second vNOTES. Ectopic pregnancy was the most frequent indication for vNOTES, with 7 cases in the first vNOTES and 11 cases in repeated vNOTES. The interval between the two vNOTESs ranged from 9 days to 38 months. The operation duration (63.33 ± 13.71 vs. 67.33 ± 22.51 min, p = 0.723), intraoperative estimated blood loss (32.00 ± 20.42 vs. 30.00 ± 9.26 mL, p = 0.429), and duration of postoperative hospital stay (2.20 ± 0.56 vs. 2.40 ± 0.51 days, p = 0.082) of both vNOTESs were comparable. No significant differences were found in any of the domains in the comparison of pre‐first and post‐first vNOTES, pre‐second and post‐second vNOTES, and pre‐first and post‐second vNOTES female sexual function index. None of the patients delivered after the second vNOTES.ConclusionRepeated vNOTES is safe and feasible. No significant change in the patients' sexual function was found in our cohort after the first and second vNOTES.
Incidence and determinants of venous thromboembolism over 90 days in hospitalized and nonhospitalized patients with COVID‐19
Authors: Tholin Birgitte , Ghanima Waleed , Selle Maria Lie , Stavem Knut 
Published: July 2023

AbstractIntroductionCOVID‐19 is associated with an increased risk of venous thromboembolism (VTE), but there is great variation among reported incidence rates. Most previous studies have focused on hospitalized patients with COVID‐19, and only a few reports are from population‐based registries.MethodsWe studied the 90‐day incidence of VTE, associated risk factors and all‐cause mortality in hospitalized and nonhospitalized patients with COVID‐19 in a nationwide cohort. Data on hospitalizations and outpatient visits were extracted from two national registries with mandatory reporting linked by a unique national identification number carried by all Norwegian residents. We performed Cox proportional hazards regression to determine risk factors for VTE after infection with SARS‐CoV‐2.ResultsOur study included 30,495 patients with positive SARS‐CoV‐2 polymerase chain reaction with a mean (SD) age of 41.9 (17.3) years, and 53% were males. Only 2081 (6.8%) were hospitalized. The 90‐day incidence of VTE was 0.3% (95% CI: 0.21–0.33) overall and 2.9% (95% CI: 2.3–3.7) in hospitalized patients. Age (hazard ratio [HR] 1.28 per decade, 95% CI: 1.11–1.48, p < 0.05), history of previous VTE (HR 4.69, 95% CI: 2.34–9.40, p < 0.05), and hospitalization for COVID‐19 (HR 23.83, 95% CI: 13.48–42.13, p < 0.05) were associated with risk of VTE.ConclusionsThe 90‐day incidence of VTE in hospitalized and nonhospitalized patients with COVID‐19 was in the lower end compared with previous reports, with considerably higher rates in hospitalized than nonhospitalized patients. Risk factors for VTE were consistent with previously reported studies.
Sex‐specific mercury levels in skin samples of southern elephant seals (Mirounga leonina) at Isla 25 de Mayo (King George Island), Antarctic Peninsula
Authors: Barragán‐Barrera Dalia C. , Riet‐Sapriza Federico G. , Mojica‐Moncada Diego F. , Negrete Javier , Curtosi Antonio , Bustamante Paco , Caballero Susana , Luna‐Acosta Andrea 
Published: July 2023

AbstractThe southern elephant seal (SES; Mirounga leonina) has a circumpolar distribution, breeding mainly on sub‐Antarctic islands and making long trips between breeding or molting and foraging areas. Most individuals from colonies in the South Shetland Islands (western Antarctic Peninsula; WAP) are distributed in Antarctic Specially Protected Areas (ASPA). Despite these protected habitats, pollutants can reach such remote areas far away from emission sources, affecting local fauna. To assess possible mercury (Hg) contamination in SES, we analyzed skin samples collected from free‐ranging molting individuals using the remote biopsy PAXARMS system in Isla 25 de Mayo/King George Island (62°15′S, 58°39′W; ASPA 132). Hairless skin samples were analyzed to determine total‐Hg (THg) concentrations, which ranged between 145 ng/g and 1,915 ng/g (M = 730, SD = 388 ng/g), showing significant differences between sexes, with adult‐females having higher concentrations (range = 306–1,915, M = 859, SD = 427 ng/g dw) than subadult‐males (range = 145–1,645, M = 629, SD = 329 ng/g dw). These differences may be explained mainly by feeding‐niche partitioning between sexes. Females prefer mesopelagic prey or prey associated with sea‐ice in the WAP, which are enriched in methylmercury. These results provide insight regarding Hg contamination in top Antarctic predators like SES, and the need to monitor for potential effects of Hg contamination in Antarctic marine mammals.