bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating real-world data to assess cardiac ablation device outcomes in a multicenter study using the OMOP common data model for regulatory decisions: implementation and evaluation
Authors: Yu Yue , Jiang Guoqian , Brandt Eric , Forsyth Tom , Dhruva Sanket S , Zhang Shumin , Chen Jiajing , Noseworthy Peter A , Doshi Amit A , Collison-Farr Kimberly , Kim Dure , Ross Joseph S , Coplan Paul M , Drozda Joseph P 
Published: January 2023

Abstract
The objective of this study is to describe application of the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) to support medical device real-world evaluation in a National Evaluation System for health Technology Coordinating Center (NESTcc) Test-Case involving 2 healthcare systems, Mercy Health and Mayo Clinic. CDM implementation was coordinated across 2 healthcare systems with multiple hospitals to aggregate both medical device data from supply chain databases and patient outcomes and covariates from electronic health record data. Several data quality assurance (QA) analyses were implemented on the OMOP CDM to validate the data extraction, transformation, and load (ETL) process. OMOP CDM-based data of relevant patient encounters were successfully established to support studies for FDA regulatory submissions. QA analyses verified that the data transformation was robust between data sources and OMOP CDM. Our efforts provided useful insights in real-world data integration using OMOP CDM for medical device evaluation coordinated across multiple healthcare systems.
Changes in milk fat globule physical properties and milk fatty acid composition throughout the lactation cycle of Laoshan goat
Authors: Fan Rongbo , Zhang Wenqing , Zhao Xiaowei , Ji Zhongyuan , Du Qijing , Han Rongwei , Wang Jun , Yang Yongxin 
Published: January 2023

AbstractThe objective of this study was to investigate the effect of lactation stage on the physical properties of milk fat globules (MFGs) and profiles of milk fatty acids (FAs) of milk from Laoshan dairy goats. Goat colostrum and milk samples were collected on days 1, 3, 30, 90, 150, and 240 postpartum. Milk fat content was found to significantly decrease during the first 90 d of lactation and increase thereafter as lactation progressed (P &lt; 0.01). Average area particle size and volume particle size of MFGs showed trends similar to those of the milk fat content of goat milk with the extension of lactation, and the lowest levels were 2.39 μm and 3.97 μm on day 90, respectively (P &lt; 0.01). The zeta-potential of MFGs significantly increased before 30 d of lactation, with a slight drop on day 90. It increased thereafter and tended to stabilize in the late stages of lactation (P &lt; 0.01). The content of several saturated fatty acids (SFAs) (C10:0-C16:0) in early lactation, especially in colostrum, was lower than that in other stages of lactation (P &lt; 0.05). Branched-chain fatty acids of the iso and anteiso series, including C13:0 anteiso, C15:0 anteiso, and C15:0 iso, were observed at high contents in mid-lactation goat milk (P &lt; 0.01). As lactation progressed (3 d to 240 d), the content of SFAs significantly increased (P &lt; 0.01), while the content of monounsaturated fatty acids and polyunsaturated fatty acids significantly decreased (P &lt; 0.05). Furthermore, the content of C18:0 significantly increased during the first 30 d of lactation and decreased thereafter as lactation progressed (P &lt; 0.01). Our results indicated that lactation stage has a pronounced effect on the physical properties of MFGs and the FA profiles of goat milk.
Different platforms, different uses: testing the effect of platforms and individual differences on perception of incivility and self-reported uncivil behavior
Authors: Sude Daniel J , Dvir-Gvirsman Shira 
Published: January 2023

Abstract
Two large surveys with adult samples of Americans (N = 1,105; N = 1,035) investigated differences in perceived incivility between seven social media platforms. Perceptions of incivility were targeted, given both their inherent societal relevance and the personalized nature of each user’s platform experience. Utilizing a novel approach, observations per platform were nested within each user, facilitating disentangling user-level from platform-level factors. Study 1 demonstrated that even accounting for differences between users, perceptions vary by platform. Further, while individual users do admit to generating uncivil content themselves, self-perceptions were in contrast largely stable across platforms. Study 2 built upon Study 1 by investigating additional platform-level factors that could impact perceptions of incivility: Differences in perceived affordances between platforms were related to differences in perceptions of incivility’s prevalence. Specifically, platforms characterized by either perceived anonymity or perceived network association were in turn perceived to be more uncivil.
Language use in online support provision: the impact of others’ supportive messages, support-seeking strategy, and channel publicness
Authors: Zhou Yanmengqian , High Andrew C 
Published: January 2023

Abstract
People benefit from high-quality supportive messages online, yet the production of these messages is a complex process that is shaped by multiple factors. As informed by the lens model, this study seeks to investigate the interplay of third party’s supportive messages as a form of behavioral residue and the support seeker’s seeking strategy as an identity claim on providers’ language use in supportive messages conveyed in public and private channels online. Data showed that providers’ use of words that differentiate supportive messages of varying quality (i.e., first-person singular pronouns, second-person pronouns, social process words, cognitive process words, and anxiety words) was influenced by the quality and quantity of others’ comments, the support-seeking strategy, and the publicness of the communication channel in an interactive way. Findings extend the literature by providing a more comprehensive account of online supportive communication and illuminating the actual language used to support others.
The One-Child Policy and Household Saving
Authors: Choukhmane Taha , Coeurdacier Nicolas , Jin Keyu 
Published: January 2023

Abstract
We investigate whether the “one-child policy” has contributed to the rise in China’s household saving rate and human capital in recent decades. In a life-cycle model with intergenerational transfers and human capital accumulation, fertility restrictions lower expected old-age support coming from children—inducing parents to raise saving and education investment in their offspring. Quantitatively, the policy can account for at least 30% of the rise in aggregate saving. Using the birth of twins under the policy as an empirical out-of-sample check to the theory, we find that quantitative estimates on saving and education decisions line up well with micro-data.
Developing Consensus on Clinical Outcomes for Children with Mild Pneumonia: A Delphi Study
Authors: Florin Todd A , Melnikow Joy , Gosdin Melissa , Ciuffetelli Ryan , Benedetti Jillian , Ballard Dustin , Gausche-Hill Marianne , Kronman Matthew P , Martin Lisa A , Mistry Rakesh D , Neuman Mark I , Palazzi Debra L , Patel Sameer J , Self Wesley H , Shah Samir S , Shah Sonal N , Sirota Susan , Cruz Andrea T , Ruddy Richard , Gerber Jeffrey S , Kuppermann Nathan 
Published: January 2023

AbstractBackgroundThe absence of consensus for outcomes in pediatric antibiotic trials is a major barrier to research harmonization and clinical translation. We sought to develop expert consensus on study outcomes for clinical trials of children with mild community-acquired pneumonia (CAP).MethodsApplying the Delphi method, a multispecialty expert panel ranked the importance of various components of clinical response and treatment failure outcomes in children with mild CAP for use in research. During Round 1, panelists suggested additional outcomes in open-ended responses that were added to subsequent rounds of consensus building. For Rounds 2 and 3, panelists were provided their own prior responses and summary statistics for each item in the previous round. The consensus was defined by &gt;70% agreement.ResultsThe expert panel determined that response to and failure of treatment should be addressed at a median of 3 days after initiation. Complete or substantial improvement in fever, work of breathing, dyspnea, tachypnea when afebrile, oral intake, and activity should be included as components of adequate clinical response outcomes. Clinical signs and symptoms including persistent or worsening fever, work of breathing, and reduced oral intake should be included in treatment failure outcomes. Interventions including receipt of parenteral fluids, supplemental oxygen, need for high-flow nasal cannula oxygen therapy, and change in prescription of antibiotics should also be considered in treatment failure outcomes.ConclusionsClinical response and treatment failure outcomes determined by the consensus of this multidisciplinary expert panel can be used for pediatric CAP studies to provide objective data translatable to clinical practice.
Littre’s hernia—a reason for resection
Authors: Seok David , Akrawe Silvy , Mittal Vijay 
Published: January 2023

Abstract
Littre’s hernias are exceedingly rare, with an estimated incidence of 0.09% in strangulated or incarcerated hernias. It may present as a complication of Meckel’s diverticulum in less than 1%. In the adult population, it presents as an inguinal (50%), femoral (20%) and umbilical (20%) hernias. Management of Meckel’s diverticulum when encountered during a routine repair of hernia in literature is generally resection. We present a case of a healthy 68-year-old gentleman who was found to have a Meckel’s diverticulum in the indirect hernia sac during routine elective open right inguinal hernia repair.
Nodulocystic basal cell carcinoma on the limb masquerading as vascular malformation on imaging
Authors: Ng Hung Shin Paul Brian , Tie Bibiana , Kanagarajah Vijay , Tan Ailin 
Published: January 2023

Abstract
Nodulocystic basal cell carcinoma (BCC) is a cystic variant of BCC, which can easily be misdiagnosed. We report a case of a 52-year-old man with a nodulocystic BCC that appeared at the site of a previously excised BCC 9 years prior. It examined as a benign cyst with a radiological signature of a vascular malformation. It was histologically confirmed on fine needle aspirate (FNA) and excisional biopsy to be a nodulocystic BCC. BCC is one of the most common paraneoplastic neoplasms affecting photo-exposed areas and displaying many variants. Nodulocystic BCC is a rarer variant that may have more than one dermoscopic face and can appear macroscopically benign. Given its malignant potential, it is imperative that it is accurately diagnosed. We highlighted that nodular cystic BCC can easily be misdiagnosed. Careful history and FNA are key differentiators to establish the correct diagnosis.
Management of fulminating non-cardiogenic pulmonary edema following cardiac surgery
Authors: Arima Takahiro , Tatebayashi Takayuki , Noji Sakashi 
Published: January 2023

Abstract
A malignant form of non-cardiogenic pulmonary edema (NCPE) that develops soon after the termination of cardiopulmonary bypass support during cardiac surgery is rarely encountered. It sometimes requires immediate management, including venovenous extracorporeal membrane oxygenation (VV-ECMO). In the first case, a 78-year-old female patient experienced fulminating NCPE after mitral valve plasty, which caused severe respiratory failure and hemodynamic instability due to a huge amount of sputum. In the second case, a 47-year-old male patient presented with right-sided unilateral pulmonary edema with a substantial amount of sputum after minimally invasive cardiac surgery for mitral valve repair. In both cases, VV-ECMO and aggressive fluid replacement were promptly initiated. The NCPE resolved on post-operative day 2, resulting in the successful termination of VV-ECMO. NCPE leads to lethal respiratory failure with multifactorial causes during cardiac surgery. However, as NCPE is potentially transient, immediate treatment comprising VV-ECMO and aggressive fluid replacement can improve clinical outcomes.
Unexpected finding of leiomyoma during laparoscopic gastric sleeve: a case report
Authors: Pérez Corzo Héctor Joaquín , Romero Suárez Angélica Katherine , Salgado Salas Roberto Esau , Nieto Segura Felipe , Verboonen Sotelo José Sergio , Romero Manzano Jeffry , Guzmán Barba José Aldo , Esparza Estrada Isaac 
Published: January 2023

Abstract
Obesity is a chronic disease with pandemic levels of prevalence worldwide. The most often performed bariatric procedure is sleeve gastrectomy. Although the patient’s history may not indicate preoperative imaging studies, coincidental findings of unexpected pathology are not uncommon, such as leiomyoma. A 41-year-old female was scheduled to laparoscopic gastric sleeve with no contraindications for surgery. A tumor-like mass was identified on the left lateral face of the distal third of the esophagus. Trans-surgical endoscopy and pneumatic test were performed to rule out any type of communication. The surgeon managed to remove the tumor mass, that was sent to histopathological study, and concluded the procedure without complications. Benign tumors of the esophagus are rarely found lesions. Occasionally unexpected findings may occur during surgery, and they should be resolved intraoperatively when possible to allow the completion of the originally planned surgical procedure.
Postoperative chylothorax after left pulmonary wedge resection without mediastinal lymph node dissection: a case report
Authors: Chen Li , Tian Bo , Xie Shaohua , Wei Xing , Li Qiang , Hu Bin 
Published: January 2023

Abstract
Postoperative chylothorax is a rare but serious complication after pulmonary resection. In previous studies, we have found no reports of postoperative chylothorax after left pulmonary wedge resection. Considering the many variations in the route of the thoracic duct, it also has the risk of postoperative chylothorax. We describe a case of refractory chylothorax after left pulmonary wedge resection without mediastinal lymph node dissection. Conservative treatment and supradiaphragmatic thoracic duct ligation did not obtain satisfactory results in this patient. Finally, under the guidance of magnetic resonance–thoracic ductography (MRTD), we successfully ligated the thoracic duct fistula. Thus, MRTD may contribute positively to being used to locate the thoracic duct and its fistula to support precise surgical intervention.
Fast and accurate predictions of the non-linear matter power spectrum for general models of Dark Energy and Modified Gravity
Authors: Bose B , Tsedrik M , Kennedy J , Lombriser L , Pourtsidou A , Taylor A 
Published: January 2023

ABSTRACT
We embed linear and non-linear parametrizations of beyond standard cosmological physics in the halo model reaction framework, providing a model-independent prescription for the non-linear matter power spectrum. As an application, we focus on Horndeski theories, using the Effective Field Theory of Dark Energy (EFTofDE) to parametrize linear and quasi-non-linear perturbations. In the non-linear regime, we investigate both a non-linear parametrized post-Friedmann (nPPF) approach as well as a physically motivated and approximate phenomenological model based on the error function (Erf). We compare the parametrized approaches’ predictions of the non-linear matter power spectrum to the exact solutions, as well as state-of-the-art emulators, in an evolving dark energy scenario and two well-studied modified gravity models, finding sub-per cent agreement in the reaction using the Erf model at z ≤ 1 and k ≤ 5 h Mpc−1. This suggests only an additional three free constants, above the background and linear theory parameters, are sufficient to model non-linear, non-standard cosmology in the matter power spectrum at scales down to k ≤ 3h Mpc−1 within $2{{\ \rm per\ cent}}$ accuracy. We implement the parametrizations into ver.2.0 of the ReACT code: ACTio et ReACTio.
Hybrid pulsar–magnetar model for FRB 20191221A
Authors: Beniamini Paz , Kumar Pawan 
Published: January 2023

ABSTRACT
We show that the 216.8 ± 0.1 ms periodicity reported for the fast radio burst (FRB) 20191221A is very constraining for burst models. The high accuracy of burst periodicity (better than one part in 103), and the 2 per cent duty cycle (ratio of burst duration and interburst interval), suggest a pulsar-like rotating beam model for the observed activity; the radio waves are produced along open field lines within ∼107 cm of the neutron star surface, and the beam periodically sweeps across the observer as the star spins. According to this picture, FRB 20191221A is a factor ∼1012 scaled up version of galactic pulsars with one major difference, whereas pulsars convert rotational kinetic energy to EM waves and the outbursts of 20191221A require conversion of magnetic energy to radiation.
Diffusion velocity of metals in Ap star atmospheres: the effect of ambipolar diffusion of H
Authors: Alecian G 
Published: January 2023

ABSTRACT
Ambipolar diffusion of hydrogen is effective in the atmosphere of stars when hydrogen is partially ionized. This is precisely the case for Ap stars whose atmospheres are stable enough to allow atomic diffusion in building metals stratification. Now, ambipolar diffusion of H induces an additional term to the diffusion velocity usually considered for metals. For some chemical elements, this may significantly affect the diffusion flux, and so, their abundance distribution. This effect decreases for high effective temperatures since protons density becomes very dominant compared to neutral H (that is partial ionization of H may be neglected), and so, this process has been neglected in recent models of abundance distributions in Bp stars. In this study, we evaluate for many metals the role of ambipolar diffusion in view of future detailed modelling of atomic diffusion for chemically peculiar stars with $T_{\rm eff}\lesssim 12\, 000$ K. We discuss a possible effect that we name the ambipolar flooding.
The brightest galaxies at cosmic dawn
Authors: Mason Charlotte A , Trenti Michele , Treu Tommaso 
Published: January 2023

ABSTRACT
Recent JWST observations suggest an excess of z ≳ 10 galaxy candidates above most theoretical models. Here, we explore how the interplay between halo formation time-scales, star formation efficiency, and dust attenuation affects the properties and number densities of galaxies observed in the early Universe. To guide intuition, we calculate the theoretical upper limit on the UV luminosity function (LF), assuming star formation is 100 per cent efficient and all gas in haloes is converted into stars, and that galaxies are at the peak age for UV emission (∼10 Myr). This upper limit is ∼4 orders of magnitude greater than current observations, implying no formal tension with star formation in Lambda cold dark matter cosmology. In a more realistic model, we use the distribution of halo formation time-scales derived from extended Press–Schechter theory as a proxy for star formation rate (SFR). We predict that the galaxies observed so far at z ≳ 10 are dominated by those with the fastest formation time-scales, and thus most extreme SFRs and young ages. These galaxies can be upscattered by ∼1.5 mag compared to the median UV magnitude versus halo mass relation. This likely introduces a selection effect at high redshift whereby only the youngest (≲10 Myr), most highly star-forming galaxies (specific SFR$\gtrsim 30\, \mathrm{Gyr}^{-1}$) have been detected so far. Furthermore, our modelling suggests that redshift evolution at the bright end of the UV LF is substantially affected by the build-up of dust attenuation. We predict that deeper JWST observations (reaching m ∼ 30) will reveal more typical galaxies with relatively older ages (∼100 Myr) and less extreme specific SFRs ($\sim 10\, \mathrm{Gyr}^{-1}$ for a MUV ∼ −20 galaxy at z ∼ 10).
Changes in the distribution of circum-binary material around the HMXB GX 301-2 during a rapid spin-up episode of the neutron star
Authors: Manikantan Hemanth , Paul Biswajit , Roy Kinjal , Rana Vikram 
Published: January 2023

ABSTRACT
Some accretion-powered X-ray pulsars with supergiant companion stars undergo occasional rapid spin-up episodes that last for weeks to a few months. We explore the changes in the accretion environment of the pulsar GX 301-2 during its latest 80 days long spin-up episode in 2019 when the spin frequency of the pulsar increased by ∼2 per cent over two orbits of the binary. By performing time-resolved spectroscopy with the MAXI/GSC spectra of the source, we estimated the equivalent hydrogen column density and equivalent width of the iron fluorescence line during the spin-up episode, and compared them with the long-term average values estimated by orbital-phase-resolved spectroscopy. The measured absorption column density during the spin-up episode is about twice that of an average orbit, while the equivalent width of the iron line is less than half of an average orbit. Though the spin-up episode started immediately after a pre-periastron flare and lasted for the two consecutive orbits of the binary, the associated enhancement in luminosity started a few days after the pre-periastron flare and lasted only during the first orbit, and some enhancement was seen again during the pre-periastron passage of the second orbit. The absorption column density and iron line equivalent width vary throughout the spin-up episode and are distinct from an average orbit. These observations indicate a significant change in the accretion and reprocessing environment in GX 301-2 during the spin-up episode and may hold important clues for the phenomenon in this source and several other sources with supergiant companions.
Radio detections of two unusual cataclysmic variables in the VLA Sky Survey
Authors: Ridder M E , Heinke C O , Sivakoff G R , Hughes A K 
Published: January 2023

ABSTRACT
We report two new radio detections of cataclysmic variables (CVs), and place them in context with radio and X-ray detections of other CVs. We detected QS Vir, a low accretion-rate CV; V2400 Oph, a discless intermediate polar; and recovered the polar AM Her in the Very Large Array Sky Survey 2–4 GHz radio images. The radio luminosities of these systems are higher than typically expected from coronal emission from stars of similar spectral types, and neither system is expected to produce jets, leaving the origin of the radio emission a puzzle. The radio emission mechanism for these two CVs may be electron–cyclotron maser emission, synchrotron radiation, or a more exotic process. We compile published radio detections of CVs, and X-ray measurements of these CVs, to illustrate their locations in the radio–X-ray luminosity plane, a diagnostic tool often used for X-ray binaries, active galactic nuclei, and radio stars. Several radio-emitting CVs, including these two newly detected CVs, seem to lie near the principal radio/X-ray track followed by black hole X-ray binaries at low luminosity, suggesting additional complexity in classifying unknown systems using their radio and X-ray luminosities alone.