bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covering the Wound: Education and the Work of Mourning
Authors: Lee Soyoung 
Published: January 2023

AbstractIn this essay, Soyoung Lee explores the theme of mourning as a way of attending to a fundamental aspect of human experience that is bound to negativity. The essay helps readers to see that experience in a different light by drawing on what is shown to be an internal connection between mourning and having language. The dominant culture of contemporary education is preoccupied with management and control, and this renders hollow the understanding of the negative experience children go through. Such experience, if it is acknowledged at all, is regarded as requiring intervention and perhaps correction. Yet negative experience, as Lee tries to show, is the very source of personal growth. This is to take human experience as wounded, and the wound as the very place for the creation of our own words. A hasty approach toward an individual's suffering, whether in the name of “healing” or “knowledge,” becomes a suppression of voice. In its denial of the otherness within the self, it neglects the possibilities of self‐transformation. The essay pursues these ideas through a reading of contrasting works of art: some poetry by Paul Celan (in conjunction with Jacques Derrida's response to it) and Still Walking, a film directed by Hirokazu Kore‐eda. Both artworks deal with their own wounds and words in ways that are instructive.
First report of branch blight disease caused by Aplosporella longipes on Physocarpus amurensis in China
Authors: Yao Chunhua , Liu Xuefeng , Diao Guiping 
Published: January 2023

AbstractFrom June through October 2020, symptoms of a branch blight disease were observed on Physocarpus amurensis plants in Harbin City, Heilongjiang Province, China. Leaves on infected branches were chlorotic, with many raised, grey spots forming on the epidermis of diseased branches. Diseased twigs formed semi‐buried, small, spherical pycnidia, which were initially light brown and later turned dark. The pathogen was isolated and its pathogenicity was verified with Koch's postulates. Based on morphological characteristics and DNA sequence data the pathogen was identified as Aplosporella longipes. This is the first report of A. longipes in China and the first report of it causing branch blight disease of P. amurensis.
Psychometric Evaluation of the Preschool Early Numeracy Skills Test–Brief Version Within the Item Response Theory Framework
Authors: Tsigilis Nikolaos , Krousorati Katerina , Gregoriadis Athanasios , Grammatikopoulos Vasilis 
Published: January 2023

AbstractThe Preschool Early Numeracy Skills Test–Brief Version (PENS‐B) is a measure of early numeracy skills, developed and mainly used in the United States. The purpose of this study was to examine the factorial validity and measurement invariance across gender of PENS‐B in the Greek educational context. PENS‐B was administered to 906 preschool children (473 boys, 433 girls), randomly selected from 84 kindergarten classrooms. A 2PL unidimensional and multidimensional item response theory analysis, using cross‐validation procedures, were used to analyze the data. Results showed that responses to 20 items can be adequately explained by a two‐dimensional model (Numbering Relations and Arithmetic Operations). Application of differential item functioning procedures did not detect any gender bias. Numeracy Relation comprises 16 items, which assess low levels of this latent trait. On the other hand, four items capture average levels of Arithmetic Operations. Total information curves revealed that both dimensions measure with precision only a small area of their underlying latent trait.
Response to erenumab assessed by Headache Impact Test‐6 is modulated by genetic factors and arterial hypertension: An explorative cohort study
Authors: Zecca Chiara , Terrazzino Salvatore , Para Davide , Campagna Giovanna , Viana Michele , Schankin Christoph J. , Gobbi Claudio 
Published: January 2023

AbstractBackground and purposeResponse predictors to erenumab (ERE) in migraine patients would benefit their clinical management. We investigate associations between patients' clinical characteristics and polymorphisms at calcitonin receptor‐like receptor (CALCRL) and receptor activity‐modifying protein 1 (RAMP1) genes and response to ERE treatment measured as clinically meaningful improvement on the Headache Impact Test‐6 (HIT‐6) score.MethodsThis post hoc analysis of a prospective, multicenter, investigator‐initiated study involves 110 migraine patients starting ERE 70 mg/month. Demographics, medical history, and migraine‐related burden measured by HIT‐6 score were collected during 3 months before and after ERE start. Selected polymorphic variants ofCALCRLandRAMP1genes were determined using real‐time polymerase chain reaction. Logistic regression models identified independent predictors for response to ERE, defined as HIT‐6 score improvement ≥ 8 points (HIT‐6 responders [HIT‐6 RESP] vs. HIT‐6 nonresponders).ResultsAt Month 3, 58 (52.7%) patients were HIT‐6 RESP. Comorbid hypertension predicted a lower probability of being HIT‐6 RESP (odds ratio [OR] = 0.160, 95% confidence interval [CI] = 0.047–0.548,p = 0.003). Compared to major alleles, minor allelesCALCRLrs6710852G andRAMPrs6431564G conferred an increased probability of being HIT‐6 RESP (for each G allele: OR = 2.82, 95% CI = 1.03–7.73,p = 0.043; OR = 2.10, 95% CI = 1.05–4.22,p = 0.037).RAMP1rs13386048A andRAMP1rs12465864G decreased this probability (for each rs13386048A, OR = 0.53, 95% CI = 0.28–0.98,p = 0.042; for each rs12465864G, OR = 0.32, 95% CI = 0.13–0.75,p = 0.009). A genetic risk score based on the presence and number of identified risk alleles was independently associated with HIT‐6 RESP (OR = 0.49, 95% CI = 0.33–0.72,p = 0.0003), surviving Bonferroni correction.ConclusionsResponse to ERE was associated with comorbid hypertension and specific allelic variants inCALCRLandRAMP1genes. Results require confirmation in future studies.
What do we currently know about incisional complications of colic surgery?
Authors: Kelmer Gal 
Published: January 2023

SummaryIt is common for horses to suffer from incisional complications after colic surgery. The complications encountered are oedema, infection, hernia and dehiscence. Oedema is a natural response to surgical trauma but when it is severe it can be associated with additional complications such as infection, hernia and dehiscence. Thus, it is worthwhile preventing marked oedema, and an abdominal bandage is an effective method for that. Infection of the incision is common, but mostly it is mild and does not require significant intervention. Many of the infections manifest after the horse is discharged from the hospital; thus, these infections are markedly underreported. Since multidrug resistance in bacteria are becoming a major problem in equine medicine, sampling the incision for monitoring is important. Hernia formation is typically preceded by incisional infection. Most hernias do not require intervention but some warrant surgical correction. The most simple and effective method to repair them is primary closure of the hernial ring followed by subcutaneous mesh implantation. By this method, one achieves both a strong body wall and a good cosmetic outlook. Complete body wall dehiscence is fortunately uncommon and is often associated with incisional infection and pregnancy. Complete body wall dehiscence usually occurs in about 5 days after surgery and is the most fatal complication. If dehiscence is noticed prior to any evisceration, conservative therapy with close monitoring and a supportive bandage is indicated and has a good chance of success. Once evisceration is noted, emergency secondary body wall closure is indicated, and the prognosis is guarded. To conclude, incisional complications are commonly encountered after colic surgery, most of them have clinically mild implications. Occasionally, these complications may become significant and even fatal. Careful attention to surgical technique and protecting the incision in the immediate post‐operative period can significantly decrease the risk of these complications.
Modeled production, oxidation, and transport processes of wetland methane emissions in temperate, boreal, and Arctic regions
Authors: Ueyama Masahito , Knox Sara H. , Delwiche Kyle B. , Bansal Sheel , Riley William J. , Baldocchi Dennis , Hirano Takashi , McNicol Gavin , Schafer Karina , Windham‐Myers Lisamarie , Poulter Benjamin , Jackson Robert B. , Chang Kuang‐Yu , Chen Jiquen , Chu Housen , Desai Ankur R. , Gogo Sébastien , Iwata Hiroki , Kang Minseok , Mammarella Ivan , Peichl Matthias , Sonnentag Oliver , Tuittila Eeva‐Stiina , Ryu Youngryel , Euskirchen Eugénie S. , Göckede Mathias , Jacotot Adrien , Nilsson Mats B. , Sachs Torsten 
Published: January 2023

AbstractWetlands are the largest natural source of methane (CH4) to the atmosphere. The eddy covariance method provides robust measurements of net ecosystem exchange of CH4, but interpreting its spatiotemporal variations is challenging due to the co‐occurrence of CH4production, oxidation, and transport dynamics. Here, we estimate these three processes using a data‐model fusion approach across 25 wetlands in temperate, boreal, and Arctic regions. Our data‐constrained model—iPEACE—reasonably reproduced CH4emissions at 19 of the 25 sites with normalized root mean square error of 0.59, correlation coefficient of 0.82, and normalized standard deviation of 0.87. Among the three processes, CH4production appeared to be the most important process, followed by oxidation in explaining inter‐site variations in CH4emissions. Based on a sensitivity analysis, CH4emissions were generally more sensitive to decreased water table than to increased gross primary productivity or soil temperature. For periods with leaf area index (LAI) of ≥20% of its annual peak, plant‐mediated transport appeared to be the major pathway for CH4transport. Contributions from ebullition and diffusion were relatively high during low LAI (<20%) periods. The lag time between CH4production and CH4emissions tended to be short in fen sites (3 ± 2 days) and long in bog sites (13 ± 10 days). Based on a principal component analysis, we found that parameters for CH4production, plant‐mediated transport, and diffusion through water explained 77% of the variance in the parameters across the 19 sites, highlighting the importance of these parameters for predicting wetland CH4emissions across biomes. These processes and associated parameters for CH4emissions among and within the wetlands provide useful insights for interpreting observed net CH4fluxes, estimating sensitivities to biophysical variables, and modeling global CH4fluxes.
The use of arts‐based methodologies and methods with young people with complex psychosocial needs: A systematic narrative review
Authors: Nathan Sally , Hodgins Michael , Wirth Jonathan , Ramirez Jacqueline , Walker Natasha , Cullen Patricia 
Published: January 2023

AbstractBackgroundArts‐based methodologies and methods (ABM) can elicit rich and meaningful data with seldom‐heard groups and empower participants in research. Young people with complex psychosocial needs could be better engaged in research using arts‐based approaches to overcome communication and literacy issues as well as distrust of those with power, including researchers. A critical review of the use and impact of ABM among this population is timely. The purpose of this review is to synthesize and examine the experience and use of ABM with young people with complex psychosocial needs.MethodsA systematic narrative literature review was conducted with a search of the literature from 2009 to 2021. All abstracts were reviewed independently by two authors and full papers were screened for eligibility against inclusion and exclusion criteria. Data synthesis focused on a descriptive numerical summary and a thematic analysis focused on key patterns across papers relating to the review objectives.Results and DiscussionA total of 25 papers were included. The most common issues of focus were mental health (n = 10) and homelessness (n = 11) and methods using Photovoice (n = 12) and Body Mapping (n = 5). Individual interview data (n = 20) were the most commonly analysed, followed by created works (n = 19). Less than half the studies involved young people in the interpretation of the data collected. Knowledge translation was not described in almost half the studies, with public exhibits (n = 7) and forums with service providers (n = 4) being the most common activities. Key themes across the studies were valued over traditional methods in eliciting data, ABM as an approach to engage these young people in research and the impact of the use of ABM on participants and on key stakeholders through knowledge translation.ConclusionsThe growing field of ABM presents opportunities to enhance research with young people with complex psychosocial needs by promoting meaningful exploration of experiences, engaging participants in research and strengthening knowledge translation. The involvement of young people in the interpretation of data and ensuring that knowledge translation occurs are key areas for future attention.Patient or Public ContributionThe findings of this review will inform future research to improve the engagement of young people with complex psychosocial needs in research and promote power sharing between researchers and research participants.
Assessment of knowledge, attitude and practice of medical and dental students about maintaining and disinfecting toothbrushes
Authors: Rajabzadeh Majid , Hajian‐Tilaki Karimollah , Ghasempour Maryam 
Published: January 2023

AbstractIntroductionProper toothbrush care and maintenance play an important role in oral health. This study aimed to investigate the knowledge, attitude and practice of medical and dental students regarding the maintenance and disinfection of toothbrushes.MethodThis cross‐sectional descriptive study examined 824 medical and dental students of Babol University of Medical Sciences, Babol, Iran. Data were collected using a researcher‐made questionnaire and analysed using chi‐square test and independent t‐test. The level of statistical significance was considered to be <0.05.ResultsNearly 63.7% of the students had a good level of knowledge regarding toothbrush maintenance, 62.2% had a positive attitude toward toothbrush care, and 53.7% had a good practice. The mean scores of knowledge, attitude, and practice were significantly higher in dental, clinical, and female students as compared to medical, preclinical, and male students, respectively. Based on the results, about 54.3% of the students kept their toothbrushes outside the bathroom; 68% kept them vertically with the bristles upright; and 54% kept them in a separate container. Also, 50.6% of the students believed that toothbrush disinfection was necessary, while 31.9% believed that only certain groups of people needed toothbrush disinfection.ConclusionThis study indicated the moderate level of knowledge, attitude, and practice of medical and dental students in maintaining and disinfecting their toothbrushes. The students' oral health habits were also at a moderate level; therefore, further improvements seem essential. To achieve this goal, educational intervention programs need to be developed in the future.
Development of a polyallylamine hydrochloride hydrogel imprinted with xylose for the purification of xylose from sugar mixture
Authors: Liu Jia , Song Qianyi , Li Youxin , Bao James J. 
Published: January 2023

SummaryA novel molecularly imprinted hydrogel (X‐MIP) was developed with poly (allylamine hydrochloride) as monomer and epichlorohydrin as crosslinker. After optimising preparation conditions including reaction temperature, the amount of NaOH and template xylose, the X‐MIP was characterised through Fourier transform infrared spectroscopy, scanning electron microscope and swelling ratio. Xylose and glucose were employed to evaluate the adsorption capacity and selectivity of the X‐MIP. Its adsorption to xylose followed pseudo‐second‐order rate kinetics and the adsorption process was multilayer adsorption based on the matched Freundlich isotherm model. Its adsorption capacity to xylose was up to 398.68 mg g−1. The similar adsorption abilities in five successive runs and the good desorption rate (98.9%) verified its reusability. The selectivity for xylose and glucose could reach 4.70, and their separation factors in simulated xylitol production feedstocks were 591.05 (xylose:glucose, 99:1) and 15.42 (xylose:glucose, 3:1), respectively. Results indicated the prepared X‐MIP has good potential in industrial xylose purification.
Effect of chestnut flour fortification on physico‐chemical characteristics of gluten‐free fresh pasta
Authors: Alinovi Marcello , Paciulli Maria , Rinaldi Massimiliano , Barbanti Davide , Chiavaro Emma 
Published: January 2023

SummaryGluten‐free (GF) products are typically characterised by lower nutritional and functional quality compared to gluten‐containing counterparts. In the last years, several studies have tried to improve the nutritional characteristics of GF products by the utilisation of alternative ingredients. In this work, the effect of three levels of chestnut flour (CF) supplementation (20, 30, 40%) on the physico‐chemical, sensory characteristics of raw and cooked GF fresh pasta, were investigated. CF showed higher water absorption properties (water binding capacity, solubility, absorption indexes) than the commercial GF mix used as control. In pasta, substitution of GF mix with CF caused a reduction in water activity and amount of freezable water due to stronger interaction of water molecules with CF components (sugars, starches, proteins). Increasing levels of CF also delivered darker, browner colour and a softer texture; the latter was also probably related to the greater cooking loss of CF, indicating a less organised network for the CF‐enriched samples compared to the control. CF also improved the antioxidant capacity, due to the presence of bioactives in chestnut integuments. CF represents a valuable ingredient for the manufacturing of functional GF pasta, more appreciated in this study at a substitution level of 30% and 40%.
The regulation of N6‐methyladenosine modification in PD‐L1‐induced anti‐tumor immunity
Authors: Yu Wei , Lin Jinti , Yu Tao , Lou Jianan , Qian Chao , Xu Ankai , Liu Bing , Tao Huimin , Jin Libin 
Published: January 2023

AbstractThere is growing evidence that programmed death ligand‐1 (PD‐L1) has exciting therapeutic efficacy in hematological malignancy and partial solid tumors. However, many patients still face failure with the treatment of immune checkpoint blockade because of PD‐L1 expression regulation during transcription and post‐transcription processes, including N6‐methyladenosine (m6A). Similar to the epigenetic regulation in DNA and histones, recent research has revealed the essential regulation of m6A modification in RNA nuclear export, metabolism and translation. Recent studies have shown that m6A‐induced PD‐L1 expression emerges as one of the main reasons for the immunological alteration in this process and contributes to the failure of T cell‐induced anti‐tumor immunity. The results of preclinical studies demonstrate the potential of m6A‐targeted therapy in combination with immune checkpoint blockade. The comprehensive expression of m6A‐related genes also provided the possibility to indicate the prognosis and to optimize the treatment for patients of various cancer types. In this review, we focus on the m6A modification in PD‐L1 mRNA as well as the regulation of PD‐L1 expression in cancer cells and summarize its clinical value in anti‐PD‐L1 cancer immune therapy.
Transmucosal abutments in the esthetic zone: Surgical and prosthetic considerations
Authors: Gamborena Iñaki , Sasaki Yoshihiro , Blatz Markus B. 
Published: January 2023

AbstractObjectiveThis article describes an updated step‐by‐step protocol for transmucosal abutment selection and treatment sequencing after immediate implant placement in the esthetic zone.Clinical ConsiderationsCurrent surgical and prosthetic concepts strive to preserve hard and soft‐tissues to provide optimal esthetics at the implant‐abutment interface. Consequently, restoring implants in the esthetic zone with transmucosal abutments presents a great challenge and must take into consideration implant depth, angulation, and bucco‐lingual position as well as transmucosal height and space for an optimized emergence profile of the restoration and the dimensions of the anterior tooth to be restored. The proper selection of the type, shape, and dimensions of implant components and connections, determined by the product portfolio offered by the implant manufacturer, play a critical role in the ability to adequately address these challenges. This article provides an update on surgical and prosthetic workflows for single implant restorations in the esthetic zone.ConclusionsFollowing esthetic, mechanical, and biologic principles, the long‐term success of implant‐supported restorations in the esthetic zone is directly correlated to proper execution and sequencing of surgical and prosthetic treatment steps, especially after immediate implant placement. These steps must be critically assessed based on the current scientific evidence to achieve the desired clinical outcomes on a predictable and consistent basis.Clinical SignificanceSelection of surgical and prosthetic treatment protocols to achieve ideal esthetic outcomes and emergence profiles in implant dentistry is often a great challenge, not only determined by technical and clinical skills of the provider but also by the type and dimensions of implant components and connections offered by the manufacturer. Following certain decision‐making principles and workflows are key for clinical success with implant‐supported restorations after immediate implant placement the esthetic zone.
Nocardia seriolae cell wall lipids: An effective protective mechanism in resistance and virulence
Authors: Nazareth Sandra Celenia , Rao Shreesha , Cheng Li‐Wu , Wang Pei‐Chi , Chen Shih‐Chu 
Published: January 2023

AbstractPiscine nocardiosis, caused by Nocardia seriolae, is a refractory granulomatous disease in South‐East Asian aquaculture. This study investigates the virulence of nocardial lipids essential for pathogenesis among Actinomycetes. Petroleum ether (PE) was used to selectively delipidate two groups of N. seriolae, namely, live cell (LC) and killed cell (KC); resulting in delipidated live cell (DLC) and delipidated killed cell (DKC), respectively. Changes post‐delipidation on genus characteristics, such as loss in acid‐fast nature and resistance to lysozyme were observed. Transmission electron microscopy revealed notable changes in the lipid layer. Additionally, Lates calcarifer, Asian seabass intraperitoneally injected with LC and DLC had mortality rates of 90% and 50%, respectively, with the latter exhibiting a delay in mortality. Reverse‐transcription quantitative PCR (RT‐qPCR) analysis of host cytokines from the spleen and head kidney showed delipidation contributed to the induction of an immune response with increased transcriptional levels of interferon‐γ (ifn‐γ). Histopathological samples collected on day 7 post‐inoculation displayed a varied granulomatous response between the treatment groups and scored for pathological changes. These findings affirm that the virulence of the lipids remains independent of the living state of the cell, significantly altering the immune and granulomatous responses in L. calcarifer to N. seriolae.