bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating ecological niche and hydrological connectivity models to assess the impacts of hydropower plants on an endemic and imperilled freshwater turtle
Authors: Regolin André Luis , Bressan Raíssa , Kunz Tobias S. , Martello Felipe , Ghizoni‐Jr Ivo R. , Cherem Jorge José , Capela Danilo José Vieira , Oliveira‐Santos Luiz Gustavo R. , Collevatti Rosane Garcia , Sobral‐Souza Thadeu 
Published: June 2023

AbstractHydropower is the main renewable energy source around the globe; however, cumulative impacts of hydropower plants (HPPs) come with vast environmental concerns. As freshwater species are susceptible to hydrodam‐induced environmental modifications, an understanding of how HPPs change species distribution is required to predict and mitigate the impacts of the expansion of hydroelectric matrices generation, securing energy provision and biodiversity conservation.We assessed the impacts of HPPs on the distribution of an endemic and imperilled freshwater turtle with very unique ecological requirements, the Williams' side‐necked turtlePhrynops williamsi. To prevent and mitigate impacts, we prioritized sites for species conservation by classifying planned HPP locations according to their predicted adverse effects on species distribution.We built ecological niche models to estimate the distribution of the species. Then, we contrasted the species distribution with current and planned HPPs in Brazil to (i) verify whether HPPs locations coincide with high suitability areas; (ii) assess the difference in the magnitude of impacts on species caused by HPPs regarding their licensing stage and type; and (iii) identify priority areas for species conservation over the sites where new HPPs are planned based on an integrative analysis of ecological niche and hydrological connectivity models. Finally, we assessed the risk of species extinction at multiple levels according to IUCN criteria.HPPs overlap areas of high suitability for the species, independently of type or licensing stage. Differences in adverse impacts among HPP types were determined by the affected area and the degree of disruption in connectivity. In the future, the area impacted by small HPPs will nearly equal those of large HPPs, which currently have the highest impacts on species. The conservation status of the species partially corroborated previous assessments and suggested that its extinction risk was underestimated at some levels.Synthesis and applications. Our modelling approach highlights potential conflicts between hydropower generation and species conservation. This analysis can be a complementary tool to drive decisions on the ecological sustainability of HPPs; it can reveal the patterns of cumulative impacts of HPPs on riverine species and freshwater ecosystems, informing the planning of sustainable energy provision.
Insect‐specific RNA virus affects the stylet penetration activity of brown citrus aphid (Aphis citricidus) to facilitate its transmission
Authors: An Xin , Gu Qiaoying , Wang Jing , Chang Tengyu , Zhang Wei , Wang Jin‐Jun , Niu Jinzhi 
Published: June 2023

AbstractSap‐sucking insects often transmit plant viruses but also carry insect viruses, which infect insects but not plants. The impact of such insect viruses on insect host biology and ecology is largely unknown. Here, we identified a novel insect‐specific virus carried by brown citrus aphid (Aphis citricidus), which we tentatively named Aphis citricidus picornavirus (AcPV). Phylogenetic analysis discovered a monophyletic cluster with AcPV and other unassigned viruses, suggesting that these viruses represent a new family in order Picornavirales. Systemic infection with AcPV triggered aphid antiviral immunity mediated by RNA interference, resulting in asymptomatic tolerance. Importantly, we found that AcPV was transmitted horizontally by secretion of the salivary gland into the feeding sites of plants. AcPV influenced aphid stylet behavior during feeding and increased the time required for intercellular penetration, thus promoting its transmission among aphids with plants as an intermediate site. The gene expression results suggested that this mechanism was linked with transcription of salivary protein genes and plant defense hormone signaling. Together, our results show that the horizontal transmission of AcPV in brown citrus aphids evolved in a manner similar to that of the circulative transmission of plant viruses by insect vectors, thus providing a new ecological perspective on the activity of insect‐specific viruses found in aphids and improving the understanding of insect virus ecology.
Comparative effect of various powder diets on growth of big‐eyed bug Geocoris ochropterus (Fieber) (Hemiptera: Geocoridae)
Authors: Chau Nguyen Ngoc Bao , Nhu Le Thuy To , Quoc Nguyen Bao 
Published: June 2023

AbstractApplication of powder diets may promote development of the predator Geocoris ochropterus (Fieber) when densities are low in greenhouses or fields. Development and nymphal survival ratio of G. ochropterus fed on different powder diets including silkworm pupae (A), crickets (B), silkworm pupae and sunflower seed (C) and crickets and sunflower seed (D) were examined. Total average development period was 30.14 days for instars fed on silkworm pupae, 34.43 days for instars fed on crickets, 26.28 days for instars fed on silkworm pupae and sunflower seed and 29.67 days for instars fed on crickets and sunflower seed, and they were significantly different. Head width, body length, forewing length, dry body weight of adults and sex ratio were not affected by the different diets. There were significantly different found in survival rates among the diets when the nymph reached 5th instar. Results indicate that the combination powder of silkworm pupae and sunflower seed will promise as an alternative diet in the greenhouses to maintain the population of G. ochropterus.
Mind the gap: The global governance of just transitions
Authors: Newell Peter , Daley Freddie , Mikheeva Olga , Peša Iva 
Published: June 2023

AbstractTransitions away from fossil fuels need to be governed, financed, regulated and coordinated, patterns of production and innovation need to be steered and shaped by rulemaking bodies at all levels of authority. For this to happen across a highly uneven international system, global institutions have a vital role to play in supporting and implementing just transitions (JTs) that align with principles addressing the procedural, distributional, intergenerational and recognition‐based aspects of justice and which help to address the temporal and spatial aspects of transitions. In this paper, we review the ways in which global institutions are involved in the governance of JTs. We illustrate the roles these institutions are playing through three key areas vital to JTs: the (i) governance of finance (ii) labour protection and (iii) mobilising alternatives. To make sense of the diverse and uneven nature of these engagements and their implications, we explore in turn four key gaps in the way global institutions are approaching the issue of JTs.
Association of sickle cell trait with adverse pregnancy outcomes in a population‐based cohort
Authors: Hulsizer Joseph , Rifkin Andrew S. , Shi Zhuqing , Wei Jun , Zheng S. Lilly , Helfand Brian T. , Morgan Jessica , Ouyang David W. , Caplan Michael S. , Xu Jianfeng 
Published: June 2023

AbstractIntroductionSickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non‐Hispanic Black women, including (1) validate the associations of SCT with previously reported APOs, (2) test novel associations of SCT with broad spectrum of APOs, and (3) estimate the attributable risk of SCT for implicated APOs.Material and methodsThis is a retrospective analysis of a prospectively designed population‐based cohort. Women/participants were self‐reported non‐Hispanic Black women from the UK Biobank (UKB). SCT status was determined based on heterozygous Glu6Val in the HBB gene. Several APOs were studied, including four previously reported SCT‐associated APOs (preeclampsia, bacteriuria, pregnancy loss, and preterm delivery), and broad conditions related to pregnancy, childbirth, and the puerperium. APOs were curated by experts’ peer review and consensus processes. Associations of SCT with APOs were tested by estimating its relative risk and 95% confidence interval (95% CI), adjusting for number of live births and age at first birth. Attributable risk proportion (ARP) and population attributable risk proportion (PARP) of SCT to APOs were estimated.ResultsAmong the 4057 self‐reported non‐Hispanic Black women with pregnancy records in the UKB, 581 (14.32%) were SCT carriers. For four previously reported SCT‐associated APOs, two were confirmed at a nominal P < 0.05; relative risk (RR) was 2.39 (95% CI 1.09–5.23) for preeclampsia, and 4.85 (95% CI 1.77–13.27) for bacteriuria. SCT contributed substantially to these two APOs among SCT carriers, with attributable risk proportion estimated at 61.00% and 68.96% for preeclampsia and bacteriuria, respectively. SCT also contributed substantially to these two APOs in the population (self‐reported Black UK women), with population attributable risk proportion estimated at 18.30% and 24.14% for preeclampsia and bacteriuria, respectively. In addition, novel associations were found for seven other APOs (nominal P < 0.05).ConclusionsSCT is significantly associated with APOs in this study and contributes substantially to APOs among self‐reported Black women in the UK. Confirmation of these findings in independent study populations is required.
Attachment‐focused iMAgery therapy for PSychosis (A‐iMAPS): A case series targeting psychosis‐related trauma
Authors: Airey Nicola D. , Berry Katherine , Taylor Christopher D. J. 
Published: June 2023

AbstractObjectivesThe experience of psychosis and its sequelae (including treatment experiences) can be traumatic and affect feelings of safety and security. Until relatively recently, trauma therapy has been avoided with psychosis populations due to concerns about additional harm. Intervention‐based research is growing, but focus on psychosis‐related trauma is limited. Engendering psychological safety may support engagement with trauma‐focused therapy, for which attachment theory provides a strong foundation. Imagery can enhance felt security and is an effective modality for working with trauma. Therefore, this study aimed to examine feasibility and preliminary outcomes of a novel attachment‐focused imagery therapy (A‐iMAPS) addressing psychosis‐related trauma.MethodsA multiple baseline case series: Participants received between two and five baseline assessments then engaged in the six‐session A‐iMAPS intervention. Participants completed weekly measures of trauma symptoms and felt security. Further measures were completed pre‐ and post‐intervention.ResultsTwelve clinical participants were recruited from NHS services in Northwest England and eight retained through baseline and intervention to the end‐of‐therapy assessment (attending all sessions). A significant improvement was seen for felt security between baseline and intervention phases. Other measures of trauma symptoms, core schemas, paranoia and attachment varied in change from baseline to end of therapy, but some promising preliminary results were seen.ConclusionsThis study shows that a brief attachment‐focused imagery therapy is a promising intervention for targeting psychosis‐related trauma, for which there are currently no other specific intervention studies. Utilizing an attachment‐informed framework when working with trauma in psychosis should be considered in future intervention studies.
‘ACOPP’ chemotherapy for older and less fit patients with Hodgkin lymphoma—A multicentre, retrospective study
Authors: Wilson Matthew R. , Haynes Euan , Parsons Katrina , Hopkins David , Robertson Elizabeth , Ferguson Graeme , Quinn Daire , Murray Jim , Osborne Wendy , Leach Mike , McKay Pam 
Published: June 2023

SummaryManagement of classical Hodgkin lymphoma in older patients is challenging due to poor tolerance of the chemotherapy regimens used in younger patients. We modified the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone), whereby bleomycin and etoposide were removed and cyclophosphamide dose was reduced, for older patients with co‐morbidities. Here we present data from the first 41 patients treated with ‘ACOPP’ across 3 centres, demonstrating that it can be delivered, with a favourable toxicity profile (TRM 2%) and promising efficacy (2‐year PFS and OS, 73% (95% CI: 52–94) and 93% (95% CI: 80–100) respectively).
Next‐generation diagnostic instruments in haematology
Authors: Nagler Michael , Nilius Henning 
Published: June 2023

Gallo et al. assessed the impact of implementing a clinical decision support tool in a multi‐hospital setting. This is one of three important points to unlock the capabilities of the next‐generation of diagnostic instruments: (a) integrating diagnostic information from various sources, (b) ensuring accurate development and validation in well‐designed clinical studies and (c) seamlessly integrating them into clinical practice.Commentary on: Gallo et al. Clinical decision support to reduce unnecessary diagnostic testing for heparin‐induced thrombocytopenia. Br J Haematol 2023;202:1011–1017.
Low‐ versus standard‐ pneumoperitoneum in patients undergoing robot‐assisted radical prostatectomy: a randomised, triple‐blinded study
Authors: Alhusseinawi Hayder , Sander Lotte , Rosenvinge Pernille M. , Jensen Sarah L. , Bruun Niels Henrik , Kingo Pernille S. , Jensen Jørgen B. , Rasmussen Sten 
Published: June 2023

ObjectiveTo investigate the effectiveness and impact of low‐pressure pneumoperitoneum (Pnp) on postoperative quality of recovery (QoR) and surgical workspace (SWS) in patients with prostate cancer undergoing robot‐assisted radical prostatectomy (RARP).Patients and MethodsA randomised, triple‐blinded trial was conducted in a single centre in Denmark from March 2021 to January 2022. A total of 98 patients with prostate cancer undergoing RARP were randomly assigned to either low‐pressure Pnp (7 mmHg) or standard‐pressure Pnp (12 mmHg). Co‐primary outcomes were postoperative QoR measured via the QoR‐15 questionnaire on postoperative Day 1 (POD1), POD3, POD14, and POD30, and SWS assessed intraoperatively by a blinded assessor (surgeon) via a validated SWS scale. Data analysis was performed according to the intention‐to‐treat principle.ResultsPatients who underwent RARP at low Pnp pressure demonstrated better postoperative QoR on POD1 (mean difference = 10, 95% confidence interval [CI] 4.4–15.5), but no significant differences were observed in the SWS (mean difference = 0.25, 95% CI −0.02 to 0.54). Patients allocated to low‐pressure Pnp experienced statistically higher blood loss than those in the standard‐pressure Pnp group (mean difference = 67 mL, P = 0.01). Domain analysis revealed significant improvements in pain (P = 0.001), physical comfort (P = 0.007), and emotional state (P = 0.006) for patients with low‐pressure Pnp. This trial was registered at ClinicalTrials.gov, NCT04755452, on 16/02/2021.ConclusionPerforming RARP at low Pnp pressure is feasible without compromising the SWS and improves postoperative QoR, including pain, physical comfort, and emotional state, compared to the standard pressure.
Clinical and prognostic features of Langerhans cell histiocytosis in adults
Authors: Sato Aki , Kobayashi Masayuki , Yusa Nozomi , Ogawa Miho , Shimizu Eigo , Kawamata Toyotaka , Yokoyama Kazuaki , Ota Yasunori , Ichinohe Tatsuo , Ohno Hitoshi , Mori Yasuo , Sakaida Emiko , Kondo Tadakazu , Imoto Seiya , Nannya Yasuhito , Mitani Kinuko , Tojo Arinobu 
Published: June 2023

AbstractLangerhans cell histiocytosis (LCH) is a rare disease characterized by clonal expansion of CD1a+CD207+ myeloid dendritic cells. The features of LCH are mainly described in children and remain poorly defined in adults; therefore, we conducted a nationwide survey to collect clinical data from 148 adult patients with LCH. The median age at diagnosis was 46.5 (range: 20–87) years with male predominance (60.8%). Among the 86 patients with detailed treatment information, 40 (46.5%) had single system LCH, whereas 46 (53.5%) had multisystem LCH. Moreover, 19 patients (22.1%) had an additional malignancy. BRAF V600E in plasma cell‐free DNA was associated with a low overall survival (OS) rate and the risk of the pituitary gland and central nervous system involvement. At a median follow‐up of 55 months from diagnosis, six patients (7.0%) had died, and the four patients with LCH‐related death did not respond to initial chemotherapy. The OS probability at 5 years post‐diagnosis was 90.6% (95% confidence interval: 79.8–95.8). Multivariate analysis showed that patients aged ≥60 years at diagnosis had a relatively poor prognosis. The probability of event‐free survival at 5 years was 52.1% (95% confidence interval: 36.6–65.5), with 57 patients requiring chemotherapy. In this study, we first revealed the high rate of relapse after chemotherapy and mortality of poor responders in adults as well as children. Therefore, prospective therapeutic studies of adults with LCH using targeted therapies are needed to improve outcomes in adults with LCH.
Health care resource utilization and clinical outcomes for adult heart transplant recipients with primary graft dysfunction
Authors: McCartney Sharon L. , Peskoe Sarah , Wright Mary Cooter , Mamoun Negmeldeen , Schroder Jacob N. , DeVore Adam D. , Nicoara Alina 
Published: June 2023

AbstractIntroductionThe advent of new technologies to reduce primary graft dysfunction (PGD) and improve outcomes after heart transplantation are costly. Adoption of these technologies requires a better understanding of health care utilization, specifically the costs related to PGD.MethodsRecords were examined from all adult patients who underwent orthotopic heart transplantation (OHT) between July 1, 2013 and July 30, 2019 at a single institution. Total costs were categorized into variable, fixed, direct, and indirect costs. Patient costs from time of transplantation to hospital discharge were transformed with the z‐score transformation and modeled in a linear regression model, adjusted for potential confounders and in‐hospital mortality. The quintile of patient costs was modeled using a proportional odds model, adjusted for confounders and in‐hospital mortality.Results359 patients were analyzed, including 142 with PGD and 217 without PGD. PGD was associated with a .42 increase in z‐score of total patient costs (95% CI: .22‐.62; p < .0001). Additionally, any grade of PGD was associated with a 2.95 increase in odds for a higher cost of transplant (95% CI: 1.94‐4.46, p < .0001). These differences were substantially greater when PGD was categorized as severe. Similar results were obtained for fixed, variable, direct, and indirect costs.ConclusionsPGD after OHT impacts morbidity, mortality, and health care utilization. We found that PGD after OHT results in a significant increase in total patient costs. This increase was substantially higher if the PGD was severe.SummaryPrimary graft dysfunction after heart transplantation impacts morbidity, mortality, and health care utilization. PGD after OHT is costly and investments should be made to reduce the burden of PGD after OHT to improve patient outcomes.
Institutional reform paths
Authors: Buchen Clemens 
Published: June 2023

AbstractThis paper develops a dynamic population game in which agents play a simple anonymous‐exchange game of cooperating or defecting. Agents switch to the strategy with a higher expected payoff. Reformers can affect the payoff structure of the stage game to maximize the number of cooperators in the population by either enacting legal reform (institutional quality of contract law) or focusing on the macro outlook of the economy. Based on the theoretical model, the paper predicts which types the reformer should enact first and under which conditions reform will not be successful.
Distance‐dependent attraction of the generalist aphid parasitoid Aphidius colemani towards synthetic volatile organic compounds under greenhouse conditions
Authors: van Neerbos Francine A. C. , Mertens Rani , Wäckers Felix L. , Bosmans Lien , Jacquemyn Hans , Lievens Bart 
Published: June 2023

AbstractManipulation of insect foraging may provide the basis for effective insect pest control strategies. Recent laboratory and small‐scale greenhouse experiments have shown that a blend of styrene and benzaldehyde is attractive to some Aphidius parasitoids, making it a good candidate for attracting and retaining these natural enemies in cropping systems. However, an appropriate dispenser type and appropriate dose for field application and its attraction range have yet to be identified. In this study, we performed experiments to determine an appropriate dispenser type – Omnilure® vs. low‐density polyethylene (LDPE) bags – and the most suitable dose to attract Aphidius colemani Viereck (Hymenoptera: Braconidae) under commercial greenhouse conditions and to determine the maximum distance of attraction. A mixture of 10 mg styrene and 100 μg benzaldehyde was the most attractive dose for A. colemani when provided by the dispensers under greenhouse conditions. The highest percentage of parasitoids was attracted when insects were released at a distance of 0.5 m from the Omnilure dispensers. Nevertheless, compared to the solvent control the blend of styrene and benzaldehyde remained attractive over a distance of up to 5 m. The potential application of these results in novel augmentation biocontrol strategies is discussed.
Equine dental caries and restoration
Authors: Rawlinson Jennifer E. 
Published: June 2023

SummaryPeripheral, infundibular, and occlusal caries can result in significant dental disease affecting the quality of life of the horse. Recognition of dental caries and understanding the grading/classification and treatment options are vital for providing optimal equine oral health care. Accurate grading of dental caries and the recognition of the importance of location on the tooth impacts treatment planning that may or may not include restoration. Restoration of teeth can be performed to reduce dental decay and improve patient comfort. Restoration of teeth requires an armoury of dental restorative equipment and materials, and it is technique sensitive requiring the practitioner to have a deep understanding of dental materials and restorative dentistry. This commentary reviews the types and grading of equine dental decay, case selection for restoration, and the treatment steps for restoration of equine caries.
A causative role for remote dural puncture and resultant arachnoid bleb in new daily persistent headache: A case report
Authors: Callen Andrew L. , Lennarson Peter , Carroll Ian R. 
Published: June 2023

AbstractA 24‐year‐old woman experienced a postdural puncture headache following a labor epidural, recovered following bedrest, and was then without headache for 12 years. She then experienced sudden onset of daily, holocephalic headache persisting for 6 years prior to presentation. Pain reduced with prolonged recumbency. MRI brain, MRI myelography, and later bilateral decubitus digital subtraction myelography showed no cerebrospinal fluid (CSF) leak or CSF venous fistula, and normal opening pressure. Review of an initial noncontrast MRI myelogram revealed a subcentimeter dural outpouching at L3–L4, suspicious for a posttraumatic arachnoid bleb. Targeted epidural fibrin patch at the bleb resulted in profound but temporary symptom relief, and the patient was offered surgical repair. Intraoperatively, an arachnoid bleb was discovered and repaired followed by remission of headache. We report that a distant dural puncture can play a causative role in the long delayed onset of new daily persistent headache.