bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contact-engineered reconfigurable two-dimensional Schottky junction field-effect transistor with low leakage currents
Authors: Zhou Yaoqiang , Tong Lei , Chen Zefeng , Tao Li , Pang Yue , Xu Jian-Bin 
Published: July 2023

AbstractTwo-dimensional (2D) materials have been considered promising candidates for future low power-dissipation and reconfigurable integrated circuit applications. However, 2D transistors with intrinsic ambipolar transport polarity are usually affected by large off-state leakage currents and small on/off ratios. Here, we report the realization of a reconfigurable Schottky junction field-effect transistor (SJFET) in an asymmetric van der Waals contact geometry, showing a balanced and switchable n- and p-unipolarity with the Ids on/off ratio kept >106. Meanwhile, the static leakage power consumption was suppressed to 10−5 nW. The SJFET worked as a reversible Schottky rectifier with an ideality factor of ~1.0 and a tuned rectifying ratio from 3 × 106 to 2.5 × 10−6. This empowered the SJFET with a reconfigurable photovoltaic performance in which the sign of the open-circuit voltage and photo-responsivity were substantially switched. This polarity-reversible SJFET paves an alternative way to develop reconfigurable 2D devices for low-power-consumption photovoltaic logic circuits.
Atomic stiffness for bulk modulus prediction and high-throughput screening of ultraincompressible crystals
Authors: Jin Ruihua , Yuan Xiaoang , Gao Enlai 
Published: July 2023

AbstractDetermining bulk moduli is central to high-throughput screening of ultraincompressible materials. However, existing approaches are either too inaccurate or too expensive for general applications, or they are limited to narrow chemistries. Here we define a microscopic quantity to measure the atomic stiffness for each element in the periodic table. Based on this quantity, we derive an analytic formula for bulk modulus prediction. By analyzing numerous crystals from first-principles calculations, this formula shows superior accuracy, efficiency, universality, and interpretability compared to previous empirical/semiempirical formulae and machine learning models. Directed by our formula predictions and verified by first-principles calculations, 47 ultraincompressible crystals rivaling diamond are identified from over one million material candidates, which extends the family of known ultraincompressible crystals. Finally, treasure maps of possible elemental combinations for ultraincompressible crystals are created from our theory. This theory and insights provide guidelines for designing and discovering ultraincompressible crystals of the future.
Block-level vulnerability assessment reveals disproportionate impacts of natural hazards across the conterminous United States
Authors: Yarveysi Farnaz , Alipour Atieh , Moftakhari Hamed , Jafarzadegan Keighobad , Moradkhani Hamid 
Published: July 2023

AbstractThe global increase in the frequency, intensity, and adverse impacts of natural hazards on societies and economies necessitates comprehensive vulnerability assessments at regional to national scales. Despite considerable research conducted on this subject, current vulnerability and risk assessments are implemented at relatively coarse resolution, and they are subject to significant uncertainty. Here, we develop a block-level Socio-Economic-Infrastructure Vulnerability (SEIV) index that helps characterize the spatial variation of vulnerability across the conterminous United States. The SEIV index provides vulnerability information at the block level, takes building count and the distance to emergency facilities into consideration in addition to common socioeconomic vulnerability measures and uses a machine-learning algorithm to calculate the relative weight of contributors to improve upon existing vulnerability indices in spatial resolution, comprehensiveness, and subjectivity reduction. Based on such fine resolution data of approximately 11 million blocks, we are able to analyze inequality within smaller political boundaries and find significant differences even between neighboring blocks.
IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
Authors: Koncina E. , Nurmik M. , Pozdeev V. I. , Gilson C. , Tsenkova M. , Begaj R. , Stang S. , Gaigneaux A. , Weindorfer C. , Rodriguez F. , Schmoetten M. , Klein E. , Karta J. , Atanasova V. S. , Grzyb K. , Ullmann P. , Halder R. , Hengstschläger M. , Graas J. , Augendre V. , Karapetyan Y. E. , Kerger L. , Zuegel N. , Skupin A. , Haan S. , Meiser J. , Dolznig H. , Letellier E. 
Published: July 2023

AbstractFibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. This subtype of fibroblasts is linked to T cell and macrophage suppression and leads to increased cancer cell growth in 3D co-culture assays. Furthermore, both a fibroblast-specific IL1R1 knockout and IL-1 receptor antagonist Anakinra administration reduce tumor growth in vivo. This is accompanied by reduced intratumoral Th17 cell infiltration. Accordingly, CRC patients who present with IL1R1-expressing cancer-associated-fibroblasts (CAFs), also display elevated levels of immune exhaustion markers, as well as an increased Th17 score and an overall worse survival. Altogether, this study underlines the therapeutic value of targeting IL1R1-expressing CAFs in the context of CRC.
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
Authors: Ghersi Joey J. , Baldissera Gabriel , Hintzen Jared , Luff Stephanie A. , Cheng Siyuan , Xia Ivan Fan , Sturgeon Christopher M. , Nicoli Stefania 
Published: July 2023

AbstractDefinitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of haemogenic endothelial cells in the aorta–gonad–mesonephros (AGM). HSPCs in the AGM are heterogeneous in differentiation and proliferative output, but how these intrinsic differences are acquired remains unanswered. Here we discovered that loss of microRNA (miR)-128 in zebrafish leads to an expansion of HSPCs in the AGM with different cell cycle states and a skew towards erythroid and lymphoid progenitors. Manipulating miR-128 in differentiating haemogenic endothelial cells, before their transition to HSPCs, recapitulated the lineage skewing in both zebrafish and human pluripotent stem cells. miR-128 promotes Wnt and Notch signalling in the AGM via post-transcriptional repression of the Wnt inhibitor csnk1a1 and the Notch ligand jag1b. De-repression of cskn1a1 resulted in replicative and erythroid-biased HSPCs, whereas de-repression of jag1b resulted in G2/M and lymphoid-biased HSPCs with long-term consequence on the respective blood lineages. We propose that HSPC heterogeneity arises in the AGM endothelium and is programmed in part by Wnt and Notch signalling.
Emissions savings from equitable energy demand reduction
Authors: Büchs Milena , Cass Noel , Mullen Caroline , Lucas Karen , Ivanova Diana 
Published: July 2023

AbstractEnergy demand reduction (EDR) will be required to reach climate targets in the Global North. To be compatible with just transitions principles, EDR needs to be equitable. Equitable EDR may involve targeting high energy users while ensuring the satisfaction of needs for all, which could require increasing consumption of low users. Emissions impacts of equitable EDR approaches have not yet been assessed. This Article finds that capping energy use of the top quintile of consumers across 27 European countries can achieve considerable greenhouse gas emissions reductions of 11.4% from domestic energy, 16.8% from transport and 9.7% from total energy consumption. Increasing consumption of low energy users in poverty reduces these savings by only 1.2, 0.9 and 1.4 percentage points, respectively. Additional high annual emissions cuts of 7.3–24.0% would be required for Europe to meet globally equitable 2050 emissions budgets. Equitable EDR could make an important contribution to increasing public acceptance of such transformative action.
DNA-origami-directed virus capsid polymorphism
Authors: Seitz Iris , Saarinen Sharon , Kumpula Esa-Pekka , McNeale Donna , Anaya-Plaza Eduardo , Lampinen Vili , Hytönen Vesa P. , Sainsbury Frank , Cornelissen Jeroen J. L. M. , Linko Veikko , Huiskonen Juha T. , Kostiainen Mauri A. 
Published: July 2023

AbstractViral capsids can adopt various geometries, most iconically characterized by icosahedral or helical symmetries. Importantly, precise control over the size and shape of virus capsids would have advantages in the development of new vaccines and delivery systems. However, current tools to direct the assembly process in a programmable manner are exceedingly elusive. Here we introduce a modular approach by demonstrating DNA-origami-directed polymorphism of single-protein subunit capsids. We achieve control over the capsid shape, size and topology by employing user-defined DNA origami nanostructures as binding and assembly platforms, which are efficiently encapsulated within the capsid. Furthermore, the obtained viral capsid coatings can shield the encapsulated DNA origami from degradation. Our approach is, moreover, not limited to a single type of capsomers and can also be applied to RNA–DNA origami structures to pave way for next-generation cargo protection and targeting strategies.
Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain
Authors: Vieira Ricardo , Mariani John N. , Huynh Nguyen P. T. , Stephensen Hans J. T. , Solly Renee , Tate Ashley , Schanz Steven , Cotrupi Natasha , Mousaei Marzieh , Sporring Jon , Benraiss Abdellatif , Goldman Steven A. 
Published: July 2023

AbstractCompetition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, we engrafted wild-type (WT) human glial progenitor cells (hGPCs) produced from human embryonic stem cells into the striata of adult mice that had been neonatally chimerized with mutant Huntingtin (mHTT)-expressing hGPCs. The WT hGPCs outcompeted and ultimately eliminated their human Huntington’s disease (HD) counterparts, repopulating the host striata with healthy glia. Single-cell RNA sequencing revealed that WT hGPCs acquired a YAP1/MYC/E2F-defined dominant competitor phenotype upon interaction with the host HD glia. WT hGPCs also outcompeted older resident isogenic WT cells that had been transplanted neonatally, suggesting that competitive success depended primarily on the relative ages of competing populations, rather than on the presence of mHTT. These data indicate that aged and diseased human glia may be broadly replaced in adult brain by younger healthy hGPCs, suggesting a therapeutic strategy for the replacement of aged and diseased human glia.
Psychological profiles of anti-vaccination argument endorsement
Authors: Holford Dawn L. , Fasce Angelo , Costello Thomas H. , Lewandowsky Stephan 
Published: July 2023

AbstractThe proliferation of anti-vaccination arguments online can threaten immunisation programmes, including those targeting COVID-19. To effectively refute misinformed views about vaccination, communicators need to go beyond providing correct information and debunking of misconceptions, and must consider the underlying motivations of people who hold contrarian views. Drawing on a taxonomy of anti-vaccination arguments that identified 11 “attitude roots”—i.e., psychological attributes—that motivate an individual’s vaccine-hesitant attitude, we assessed whether these attitude roots were identifiable in argument endorsements and responses to psychological construct measures corresponding to the presumed attitude roots. In two UK samples (total n = 1250), we found that participants exhibited monological belief patterns in their highly correlated endorsements of anti-vaccination arguments drawn from different attitude roots, and that psychological constructs representing the attitude roots significantly predicted argument endorsement strength and vaccine hesitancy. We identified four different latent anti-vaccination profiles amongst our participants’ responses. We conclude that endorsement of anti-vaccination arguments meaningfully dovetails with attitude roots clustering around anti-scientific beliefs and partisan ideologies, but that the balance between those attitudes differs considerably between people. Communicators must be aware of those individual differences.
Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients
Authors: van Genugten Evelien A. J. , van Lith Theresa J. , van den Heuvel Frederik M. A. , van Steenis Josee L. , ten Heggeler Romy M. , Brink Monique , Rodwell Laura , Meijer Frederick J. A. , Lobeek Daphne , Hagmolen of ten Have Wanda , van de Veerdonk Frank L. , Netea Mihai G. , Prokop Mathias , Nijveldt Robin , Tuladhar Anil M. , Aarntzen Erik H. J. G. 
Published: July 2023

AbstractIn coronavirus disease 2019 (COVID-19), endothelial cells play a central role and an inadequate response is associated with vascular complications. PET imaging with gallium-68 labelled RGD-peptide (68Ga-RGD) targets αvβ3 integrin expression which allows quantification of endothelial activation. In this single-center, prospective observational study, we included ten hospitalized patients with COVID-19 between October 2020 and January 2021. Patients underwent 68Ga-RGD PET/CT followed by iodine mapping of lung parenchyma. CT-based segmentation of lung parenchyma, carotid arteries and myocardium was used to quantify tracer uptake by calculating standardized uptake values (SUV). Five non-COVID-19 patients were used as reference. The study population was 68.5 (IQR 52.0–74.5) years old, with median oxygen need of 3 l/min (IQR 0.9–4.0). 68Ga-RGD uptake quantified as SUV ± SD was increased in lungs (0.99 ± 0.32 vs. 0.45 ± 0.18, p < 0.01) and myocardium (3.44 ± 1.59 vs. 0.65 ± 0.22, p < 0.01) of COVID-19 patients compared to reference but not in the carotid arteries. Iodine maps showed local variations in parenchymal perfusion but no correlation with SUV. In conclusion, using 68Ga-RGD PET/CT in COVID-19 patients admitted with respiratory symptoms, we demonstrated increased endothelial activation in the lung parenchyma and myocardium. Our findings indicate the involvement of increased and localized endothelial cell activation in the cardiopulmonary system in COVID-19 patients.Trail registration: NCT04596943.
Elite male table tennis matches diagnosis using SHAP and a hybrid LSTM–BPNN algorithm
Authors: Song Honglin , Li Yutao , Zou Xiaofeng , Hu Ping , Liu Tianbiao 
Published: July 2023

AbstractThis study adopts a new approach, SHapley Additive exPlanation (SHAP), to diagnose the table tennis matches based on a hybrid algorithm, namely Long Short-Term Memory–Back Propagation Neural Network (LSTM–BPNN). 100 male singles competitions (8535 rallies) from 2019 to 2022 are analyzed by a hybrid technical–tactical analysis theory, which hybridizes the double three-phase and four-phase evaluation theories. A k-means cluster analysis is conducted to classify 59 players’ winning rates into three levels (high, medium, and low). The results show that LSTM–BPNN has excellent performance (MSE = 0.000355, MAE = 0.014237, RMSE = 0.018853, and$${\mathrm{R}}^{2}$$R2= 0.988311) compared with six typical artificial intelligence algorithms. Using LSTM–BPNN to calculate the SHAP value of each feature, the global results find that the receive-attack and serve-attack phases of the ending match have essential impacts on the mutual winning probabilities. Finally, case applications show that the SHAP can directly obtain each feature importance on one or more matches, which is more objective and reliable than the traditional simulation method. This research explores an innovative way to understand and analyze matches, and these results have implications for the performance analysis of table tennis and related racket sports.
Ferromagnetism in two-dimensional metal dibromides induced by hole-doping
Authors: Meng Ruishen , Houssa Michel 
Published: July 2023

AbstractUsing spin-polarized first-principles calculations based on density functional theory, we study the stability, electronic properties and magnetic behavior induced by hole-doping of two-dimensional (2D) PbBr2 and HgBr2. Although inherently nonmagnetic, these materials can exhibit stable ferromagnetic order when hole-doped at densities above a few 1013 cm-2. We also examined the impact of intrinsic and extrinsic defects on inducing hole-doping and subsequent ferromagnetism. Our findings suggest that p-type doping can be achieved by Pb and Hg vacancies and Br antisites, but the latter behaves as deep acceptors. Among the possible dopants we considered, Li substituting Pb or Hg, and S replacing Br in 2D HgBr2, can produce shallow acceptor states near the valence band edges and potentially result in a stable ferromagnetic order in these 2D dibromides.
Predicting overall performance in Ironman 70.3 age group triathletes through split disciplines
Authors: Nikolaidis Pantelis Theodoros , Valero David , Weiss Katja , Villiger Elias , Thuany Mabliny , Sousa Caio Victor , Andrade Marilia , Knechtle Beat 
Published: July 2023

AbstractKnowing which discipline contributes most to a triathlon performance is important to plan race pacing properly. To date, we know that the running split is the most decisive discipline in the Olympic distance triathlon, and the cycling split is the most important discipline in the full-distance Ironman® triathlon. However, we have no knowledge of the Ironman® 70.3. This study intended to determine the most crucial discipline in age group athletes competing from 2004 to 2020 in a total of 787 Ironman® 70.3 races. A total of 823,459 athletes (198,066 women and 625,393 men) from 240 different countries were analyzed and recorded in 5-year age groups, from 18 to 75 + years. Correlation analysis, multiple linear regression, and two-way ANOVA were applied, considering p < 0.05. No differences in the regression analysis between the contributions of the swimming, cycling, and running splits could be found for all age groups. However, the correlation analysis showed stronger associations of the cycling and running split times than the swimming split times with overall race times and a smaller difference in swimming performance between males and females in age groups 50 years and older. For age group triathletes competing in Ironman® 70.3, running and cycling were more predictive than swimming for overall race performance. There was a progressive reduction in the performance gap between men and women aged 50 years and older. This information may aid triathletes and coaches in planning their race tactics in an Ironman® 70.3 race.
Evaluation of stresses on mandible bone and prosthetic parts in fixed prosthesis by utilizing CFR-PEEK, PEKK and PEEK frameworks
Authors: Shash Yomna H. , El-Wakad Mohamed T. , El-Dosoky Mohamed A. A. , Dohiem Mohamed M. 
Published: July 2023

AbstractFixed prostheses are appropriate treatment solutions for edentulous patients. In fixed prostheses, following “All on four”, titanium frameworks are commonly used to support the implants. However, the limitations of titanium have prompted researchers to search for alternative materials (e.g. polymers). This study applied finite element investigation to evaluate the stress distribution in the parts of fixed prosthesis and the surrounding bone tissue, using polymeric frameworks in place of titanium, and different densities of spongy bone. As, the success of fixed prosthesis was predicted to be influenced also by bone quality, particularly spongy bone density. Fixed prosthesis was constructed on edentulous mandible, then different frameworks (CFR-PEEK 60%, CFR-PEEK 30%, PEKK, and PEEK) were stimulated instead of titanium, under 300N unilateral and bilateral forces. Three densities of spongy bone were stimulated which are normal, low and high. The choice of framework material depended on the density of spongy bone. Moreover, PEEK framework showed the lowest stress values on bone tissues and the highest stress values on mucosa. All frameworks could be used in the fixed prosthesis, in the cases of normal and high densities of spongy bone. In low-density case, soft frameworks (PEKK and PEEK) were recommended to reduce the stresses generated on bone tissues.
Super-resolution of magnetic systems using deep learning
Authors: Lee D. B. , Yoon H. G. , Park S. M. , Choi J. W. , Chen G. , Kwon H. Y. , Won C. 
Published: July 2023

AbstractWe construct a deep neural network to enhance the resolution of spin structure images formed by spontaneous symmetry breaking in the magnetic systems. Through the deep neural network, an image is expanded to a super-resolution image and reduced to the original image size to be fitted with the input feed image. The network does not require ground truth images in the training process. Therefore, it can be applied when low-resolution images are provided as training datasets, while high-resolution images are not obtainable due to the intrinsic limitation of microscope techniques. To show the usefulness of the network, we train the network with two types of simulated magnetic structure images; one is from self-organized maze patterns made of chiral magnetic structures, and the other is from magnetic domains separated by walls that are topological defects of the system. The network successfully generates high-resolution images highly correlated with the exact solutions in both cases. To investigate the effectiveness and the differences between datasets, we study the network’s noise tolerance and compare the networks’ reliabilities. The network is applied with experimental data obtained by magneto-optical Kerr effect microscopy and spin-polarized low-energy electron microscopy.
Predicting current and future high-risk areas for vectors and reservoirs of cutaneous leishmaniasis in Iran
Authors: Bozorg-Omid Faramarz , Kafash Anooshe , Jafari Reza , Akhavan Amir Ahmad , Rahimi Mohammad , Rahimi Foroushani Abbas , Youssefi Fahimeh , Shirzadi Mohammad Reza , Ostadtaghizadeh Abbas , Hanafi-Bojd Ahmad Ali 
Published: July 2023

AbstractClimate change will affect the distribution of species in the future. To determine the vulnerable areas relating to CL in Iran, we applied two models, MaxEnt and RF, for the projection of the future distribution of the main vectors and reservoirs of CL. The results of the models were compared in terms of performance, species distribution maps, and the gain, loss, and stable areas. The models provided a reasonable estimate of species distribution. The results showed that the Northern and Southern counties of Iran, which currently do not have a high incidence of CL may witness new foci in the future. The Western, and Southwestern regions of the Country, which currently have high habitat suitability for the presence of some vectors and reservoirs, will probably significantly decrease in the future. Furthermore, the most stable areas are for T. indica and M. hurrianae in the future. So that, this species may remain a major reservoir in areas that are present under current conditions. With more local studies in the field of identifying vulnerable areas to CL, it can be suggested that the national CL control guidelines should be revised to include a section as a climate change adaptation plan.