bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instruments measuring evidence-based practice behavior, attitudes, and self-efficacy among healthcare professionals: a systematic review of measurement properties
Authors: Landsverk Nils Gunnar , Olsen Nina Rydland , Brovold Therese 
Published: September 2023

Abstract
Background
Evidence-based practice (EBP) is well known to most healthcare professionals. Implementing EBP in clinical practice is a complex process that can be challenging and slow. Lack of EBP knowledge, skills, attitudes, self-efficacy, and behavior can be essential barriers that should be measured using valid and reliable instruments for the population in question. Results from previous systematic reviews show that information regarding high-quality instruments that measure EBP attitudes, behavior, and self-efficacy in various healthcare disciplines need to be improved. This systematic review aimed to summarize the measurement properties of existing instruments that measure healthcare professionals’ EBP attitudes, behaviors, and self-efficacy.

Methods
We included studies that reported measurement properties of instruments that measure healthcare professionals’ EBP attitudes, behaviors, and self-efficacy. Medline, Embase, PsycINFO, HaPI, AMED via Ovid, and Cinahl via Ebscohost were searched in October 2020. The search was updated in December 2022. The measurement properties extracted included data on the item development process, content validity, structural validity, internal consistency, reliability, and measurement error. The quality assessment, rating of measurement properties, synthesis, and modified grading of the evidence were conducted in accordance with the COSMIN methodology for systematic reviews.

Results
Thirty-four instruments that measure healthcare professionals’ EBP attitudes, behaviors or self-efficacy were identified. Seventeen of the 34 were validated in two or more healthcare disciplines. Nurses were most frequently represented (n = 53). Despite the varying quality of instrument development and content validity studies, most instruments received sufficient ( +) ratings on content validity, with the quality of evidence graded as “very low” in most cases. Structural validity and internal consistency were the measurement properties most often assessed, and reliability and measurement error were most rarely assessed. The quality assessment results and overall rating of these measurement properties varied, but the quality of evidence was generally graded higher for these properties than for content validity.

Conclusions
Based on the summarized results, the constructs, and the population of interest, several instruments can be recommended for use in various healthcare disciplines. However, future studies should strive to use qualitative methods to further develop existing EBP instruments and involve the target population.

Trial registration
This review is registered in PROSPERO. CRD42020196009. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020196009
Ultrasound-guided acupotomy for trigger finger: a systematic review and meta-analysis
Authors: Liang Yong-shan , Chen Ling-yan , Cui Yao-yun , Du Chun-xiao , Xu Yun-xiang , Yin Lun-hui 
Published: September 2023

Abstract
Background
Trigger finger is a common condition in the hand, and ultrasound-guided acupotomy for trigger finger has been widely used in recent years.

Purpose
This study aims to investigate the efficacy and safety of ultrasound-guided acupotomy for trigger finger.

Methods
We searched for relevant studies in the Cochrane Library, China National Knowledge Infrastructure (CNKI), Embase, PubMed, Chinese Biomedical Literature Database (CBM), Wanfang Data, and other resources from their inception to January 2023. Randomized controlled trials of ultrasound-guided acupotomy for trigger finger were included. The meta-analysis was carried out using Review Manager 5.4 and Stata 15.1.

Results
Overall, 15 studies with 988 patients were included. The experimental group was treated with ultrasound-guided acupotomy, and the Control group received traditional acupotomy, traditional operation or injection of medication. Meta-analysis showed that the overall clinical effectiveness (OR = 4.83; 95% CI 2.49–9.37; I2 = 73.1%; P < 0.001) in the experimental group was significantly better than that of the control group. And the Visual Analogue Scale (VAS) score (WMD =  − 1; 95% CI − 1.24, − 0.76; I2 = 99%; P < 0.001), the QuinneII classification (WMD = − 0.84; 95% CI − 1.28, − 0.39; I2 = 99.1%, P < 0.001), the incidence of complications (RR = 0.26; 95% CI 0.11, 0.63; I2 = 0%, P = 0.003), and the recurrence rate (RR = 0.14; 95% CI 0.03, 0.74; I2 = 0%; P = 0.021) were significantly lower in the experimental group.

Conclusion
Our systematic review and meta-analysis can prove the effectiveness and safety of ultrasound-guided acupotomy in the treatment of trigger finger, but this still needs to be verified by a clinical standard large sample test.
Peripheral blood microR-146a and microR-29c expression in children with Mycoplasma pneumoniae pneumonia and its clinical value
Authors: Wang Jingcai , Guo Chunyan , Yang Lixin , Sun Peng , Jing Xiaoqing 
Published: September 2023

Abstract
Background
We investigated changes in microR-29c and microR-146a expression in the serum of children with Mycoplasma pneumoniae pneumonia, analysed their relationship with inflammatory factors and disease severity, and evaluated their diagnostic significance.

Methods
Fifty-six children with Mycoplasma pneumoniae pneumonia were enrolled as the Mycoplasma pneumoniae pneumonia group; 37 healthy children were enrolled as the control group. The microR-29c or microR-146a serum expression levels were determined using real-time quantitative reverse transcription polymerase chain reaction. Interleukin-17, tumour necrosis factor-alpha, and interleukin-1 beta levels were detected using enzyme-linked immunosorbent assay. The correlation between serum microR-29c or microR-146a expression and inflammatory factors was analysed using the Pearson’s method. Receiver operating characteristic curves were used to evaluate the diagnostic value of serum microR-29c, microR-146a, and their combined detection in Mycoplasma pneumoniae pneumonia.

Results
Compared with that in healthy children, the microR-29c and microR-146a serum levels were significantly downregulated in children with Mycoplasma pneumoniae pneumonia; the decrease was more obvious in children with severe cases than that in those with mild cases. In addition, microR-29c and microR-146a were negatively correlated with increased expression of interleukin-17, tumour necrosis factor-alpha, and interleukin-1 beta. Receiver operating characteristic curves showed that a combination of microR-29c and microR-146a was highly suitable for diagnosing Mycoplasma pneumoniae pneumonia.

Conclusion
Serum microR-29c and microR-146a were underexpressed in children with Mycoplasma pneumoniae pneumonia, and diagnostic accuracy was significantly improved with combined microR-29c and microR-146a detection. Therefore, both microR-29c and microR-146a levels can be used as biomarkers for the diagnosis of Mycoplasma pneumoniae pneumonia.
Glycaemic control using mobile-based intervention in patients with diabetes undergoing coronary artery bypass—study protocol for a randomized controlled trial
Authors: Song Yangwu , Nan Yifeng , Feng Wei 
Published: September 2023

Abstract
Background
Applying technology through the use of the Internet and mobile phones can help provide education and trained peer support for patients with diabetes after coronary artery bypass (CABG). We are conducting a randomized controlled trial to evaluate the efficacy and feasibility of mobile-based coaching intervention in improving risk-factor control and secondary prevention in patients with diabetes after CABG.

Methods
The glycaemic control using miniprogram-based intervention in patients with diabetes undergoing coronary artery bypass to promote self-management (GUIDE ME) study is a multi-centre, randomized controlled trial of mobile intervention versus standard treatment with 6 months follow-up conducted in 2 hospitals in China. The interventions are education and a reminder system based on the WeChat mini-program. Participants in the intervention groups receive 180 videos (including lines) about secondary prevention education for 6 months as well as the standard treatment. Behavioural change techniques, such as prompting barrier identification, motivational skills, and goal setting, are employed. A total sample size of 820 patients would be adequate for the GUIDE ME study. The primary outcome is the change of glycaemic haemoglobin (HbA1c) at 6 months. Secondary outcomes include a change in the proportions of patients achieving HbA1c, fasting blood glucose, systolic blood pressure, low-density lipoprotein cholesterol (LDL-C) and medication adherence.

Discussion
This trial is the first to investigate the efficacy of mobile phone WeChat-based video coaching and medication reminder mini-program system to improve self-management in patients with diabetes and coronary heart disease (CHD) after CABG and has the potential to be applied in resource-limited settings across diverse populations. If successful, such mobile intervention could be used and scaled up to improve care for this high-risk group of patients.

Trial registration
ClinicalTrials, NCT04192409. Registered on December 10, 2019.
Echocardiographic parameters in COVID-19 patients and their association with ICU mortality: a prospective multicenter observational study
Authors: Havaldar Amarja Ashok , Kumar Merugu Vinay , Kumar Raman , Yarramalle Surya Prakash , Khan Mohammad Saif , Misra Krushna Chandra , Kamble Shubhangi , Sangale Atul , Prakash Jay , Kartik Munta , Selvam Sumithra 
Published: September 2023

Abstract
Background
Echocardiography has become an integral part of the management of critically ill patients. It helps to diagnose and treat various conditions. COVID-19 patients can develop cardiac dysfunction. We planned to study the echocardiographic parameters in COVID-19 patients.

Methods
We conducted a prospective observational multicenter study after institutional ethical committee approval. COVID-19 pneumonia patients admitted to the intensive care unit (ICU) were enrolled. The echocardiographic evaluation was done within 24–48 hours of admission. Assessment of the left and right heart with systolic and left ventricular diastolic function evaluation was done. The primary outcome was ICU mortality. The secondary outcomes were the length of ICU stay and duration of mechanical ventilation.

Results
Among 573 patients mean age was 57.17 (14.67) with 68.60% being males. On day 1 of ICU, invasive mechanical ventilation was used in 257 (45%) patients. One hundred and forty-eight (25.83%) patients were on vasopressors when echocardiography was performed. Severe left ventricle (LV) systolic dysfunction was seen in 8.7% of patients and had higher odds of mortality [2.48(1.058–5.807), p = 0.037] followed by E and e′ with odds ratio of [0.984(0.971–0.998), p = 0.021] and 0.897 (0.805–0.998), p = 0.046], respectively. E/e′ indicative of filling pressure of the LV was not found to be significant. Troponin I, E/A, and RV dilatation were similar among survivors and non-survivors.

Conclusion
Echocardiographic evaluation in COVID-19 patients showed severe LV systolic dysfunction was associated with ICU mortality. E/e′ was not found to be significant but lower e′ was associated with higher mortality.
Trial registration IEC 131/2020, CTRI/2020/06/025858 date 13th June 2020
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway
Authors: Yan Shu Wei , Zhang Ru , Guo Xin , Wang Bo Ning , Long Shao Rong , Liu Ruo Dan , Wang Zhong Quan , Cui Jing 
Published: September 2023

AbstractTrichinella spiralis dipeptidyl peptidase 1 (TsDPP1), or cysteine cathepsin C, is a secretory protein that is highly expressed during the infective larvae and adult worm stages in the intestines. The aim of this study was to investigate the mechanism by which recombinant TsDPP1 (rTsDPP1) activates macrophages M2 polarization and decreases macrophage cytotoxicity to kill newborn larvae via ADCC. RAW264.7 macrophages and murine peritoneal macrophages were used in this study. The results of the immunofluorescence test (IFT) and confocal microscopy showed that rTsDPP1 specifically bound to macrophages, and the binding site was localized on the cell membrane. rTsDPP1 activated macrophage M2 polarization, as demonstrated by high expression levels of Arg1 (M2 marker) and M2-related genes (IL-10, TGF-β, CD206 and Arg1) and high numbers of CD206+ macrophages. Furthermore, the expression levels of p-STAT6, STAT6 and PPARγ were obviously increased in rTsDPP1-treated macrophages, which were evidently abrogated by using a STAT6 inhibitor (AS1517499) and PPARγ antagonist (GW9662). The results indicated that rTsDPP1 promoted macrophage M2 polarization through the STAT6/PPARγ pathway. Griess reaction results revealed that rTsDPP1 suppressed LPS-induced NO production in macrophages. qPCR and flow cytometry results showed that rTsDPP1 downregulated the expression of FcγR I (CD64) in macrophages. The ability of ADCC to kill newborn larvae was significantly decreased in rTsDPP1-treated macrophages, but AS1517499 and GW9662 restored its killing capacity. Our results demonstrated that rTsDPP1 induced macrophage M2 polarization, upregulated the expression of anti-inflammatory cytokines, and inhibited macrophage-mediated ADCC via activation of the STAT6/PPARγ pathway, which is beneficial to the parasitism and immune evasion of this nematode.
The gametogenic cycle and spawning of the short-necked clam, Paphia undulata Born, 1778 (Bivalvia: Veneridae) from Timsah Lake, Suez Canal, Egypt
Authors: Mahmoud Mostafa A. M. , Yassien Mohamed H. 
Published: September 2023

Abstract
Background
Paphia undulata, The Short-Necked Clam, is an edible marine bivalve that is consumed internationally and locally in Egypt. Overfishing and pollution have caused population declines in Egyptian fisheries during the last decade. Accurate reproductive biology knowledge is critical for designing long-term exploitation strategy for this resource. P. undulata spawning and gametogenic cycle research were carried out from January to December 2020 along Timsah Lake, Suez Canal, Egypt.

Results
These clams are functionally dioecious with a very low incidence of hermaphroditism. The sex ratio of the clam population was 1.0:1.07:0.04 for male, female and hermaphrodite respectively. The shell lengths of the collected clams were 4.64 ± 0.83 cm in males, 4.55 ± 0.9 cm in females and 4.19 ± 0.3 cm in hermaphrodite clams. The sizes at the onset of sexual maturity in both males and females were 2.1 cm and 2.5 cm respectively.

Conclusions
Reproductive studies revealed that this species has a prolonged spawning season that is not restricted to a specific period.
Ovarian cancer beyond imaging: integration of AI and multiomics biomarkers
Authors: Hatamikia Sepideh , Nougaret Stephanie , Panico Camilla , Avesani Giacomo , Nero Camilla , Boldrini Luca , Sala Evis , Woitek Ramona 
Published: September 2023

AbstractHigh-grade serous ovarian cancer is the most lethal gynaecological malignancy. Detailed molecular studies have revealed marked intra-patient heterogeneity at the tumour microenvironment level, likely contributing to poor prognosis. Despite large quantities of clinical, molecular and imaging data on ovarian cancer being accumulated worldwide and the rise of high-throughput computing, data frequently remain siloed and are thus inaccessible for integrated analyses. Only a minority of studies on ovarian cancer have set out to harness artificial intelligence (AI) for the integration of multiomics data and for developing powerful algorithms that capture the characteristics of ovarian cancer at multiple scales and levels. Clinical data, serum markers, and imaging data were most frequently used, followed by genomics and transcriptomics. The current literature proves that integrative multiomics approaches outperform models based on single data types and indicates that imaging can be used for the longitudinal tracking of tumour heterogeneity in space and potentially over time. This review presents an overview of studies that integrated two or more data types to develop AI-based classifiers or prediction models.Relevance statement Integrative multiomics models for ovarian cancer outperform models using single data types for classification, prognostication, and predictive tasks.Key points• This review presents studies using multiomics and artificial intelligence in ovarian cancer.• Current literature proves that integrative multiomics outperform models using single data types.• Around 60% of studies used a combination of imaging with clinical data.• The combination of genomics and transcriptomics with imaging data was infrequently used.
Graphical Abstract
Harnessing the energy transition from total dependence on fossil to renewable energy in the Arabian Gulf region, considering population, climate change impacts, ecological and carbon footprints, and United Nations’ Sustainable Development Goals
Authors: Salem Hilmi S. , Pudza Musa Yahaya , Yihdego Yohannes 
Published: September 2023

AbstractThe aim of this research is to investigate various issues related to oil consumption and environmental impacts in the Gulf Cooperation Council (GCC) countries, in relation to population, climate change impacts, United Nations Sustainable Development Goals (UN’s SDGs), and ecological and carbon footprints. The GCC countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) are almost entirely dependent on fossil energy sources (oil and natural gas) domestically, industrially, commercially, economically, and transportation-wise. Although the total population of the GCC countries is around 60 million, making up only 0.76% of the world’s population (8 billion), they do consume 5.15 million barrels per day (bbl/d) of oil, forming nearly 5.8% of the world’s daily consumption, which is around 88.4 million bbl/d as of 2021. Moreover, daily per capita consumption of oil in the GCC countries is about 0.09 barrels, while it is about 0.06 barrels in the USA. These figures indicate that the GCC’s countries combined and per capita, although not industrialized and small in population, consume large quantities of oil, compared to other countries of the world that are industrialized and/or densely populated, such as the USA, India, Japan, Russia, and Germany. The high rates of oil consumption in the GCC countries, associated with the highest per capita ecological and carbon footprints worldwide, have led to negative impacts on the environment, climate, and public health. The results of this work show that some of the GCC countries have the highest per capita ecological and carbon footprints. Thus, the GCC countries should effectively reduce their dependence on fossil energy sources and gradually replace them with renewable energy sources, especially photovoltaic (PV) solar energy. Furthermore, the statistics presented in this article and the outcomes reached uncover that the GCC countries lag behind with regard to various indicators of the UN’s SDGs. This implies the GCC countries are not taking adequate actions to encounter environmental problems, in order to fulfill some of the UN’s SDGs by 2030.
People's migrations and plants for food: a review for fostering sustainability
Authors: Hanazaki Natalia , Pieroni Andrea , Ludwinsky Rafaela Helena , Gonçalves Maiara Cristina , Prakofjewa Julia , Peroni Nivaldo , Soukand Renata 
Published: September 2023

AbstractHuman movements via migrations facilitate the transport of plants and knowledge. Migrations were always present in our human history, but conflicts and environmental changes are contributing to the increase in people’s movements to and from different parts of the world. In this literature review, our focus is on the ethnobotany of food plants and migrations, and the adaptations following this process. We analyzed 58 studies dealing with human migrations and food plants, including both internal migrations and international ones, over a wide period from several centuries to the present but with the predominance of migrations since the second half of the twentieth century. Most studies reported migrations between countries or regions (80%) in which people search for better economic opportunities. Other reasons for migrations were refugees, mandatory displacements, and slavery. The studies included cultivated plants, gathered plants (foraged), and food plants purchased on markets or obtained via exchanges or importation. We discuss the identitarian role of food plants in the processes of maintenance, abandonment, replacement, and incorporation of plants; although the evidences of abandonment are the most difficult to track. After the migration, the maintenance of a food identity will depend on several variables, including how important it is to keep a distinct identity, the plant resources available, the people’s agency of the plant resources, and also the reasons for each migratory movement. Finally, we discuss the implications of this ethnobotanical knowledge and practices related to food plants for sustainability.
Diffusion tensor imaging in trigeminal neuralgia: beyond the normal morphology
Authors: Elkholy Shaima Fattouh , Gadalla Amr Abd Elfattah Hassan , Mohammad Mohammad Edrees , Mahmoud Bahaa Eldin 
Published: September 2023

Abstract
Background
Trigeminal neuralgia (TN) is an electric-like recurrent pain of a sudden onset and is localized to the area supplied by the trigeminal nerve, and the patients are usually free in between the attacks. It’s one of the most common causes of facial pain and is commonly induced by mechanical irritation, and there’s strong evidence suggesting an insult at the trigeminal nerve root which is usually caused by a neurovascular compression. The aim of the study was to evaluate the role of diffusion tensor imaging (DTI) in the detection of microstructural changes of normal appearing trigeminal nerve in patients with trigeminal neuralgia and the correlation between DTI parameters and pain severity.

Results
Thirty one cases were included in the study (16 patients with TN and 15 healthy controls) underwent MRI with diffusion tensor imaging. The fractional anisotropy (FA) values of the trigeminal nerves were recorded and then comparison between the affected and unaffected sides in TN patients and healthy controls was done, also the degree of FA reduction was correlated with the pain severity in TN groups. The mean FA value of the affected trigeminal nerves was 0.43 ± 0.083, while that of the unaffected sides was 0.56 ± 0.058. The mean FA value of the trigeminal nerves in the healthy controls was 0.54 ± 0.057. A significant statistical differences was found between affected and unaffected sides (P < 0.00001) and between the affected sides and healthy controls (P < 0.0003), while no statistically significant difference was detected between the unaffected side and the healthy controls. A strong negative correlation was found between the pain score and the degree of FA reduction (P < 0.001).

Conclusions
Diffusion tensor imaging is a functional MRI technique which can detect the microstructural changes in the normal appearing trigeminal nerves in patients with trigeminal neuralgia with a strong negative correlation between the severity of pain and the degree of FA reduction of the affected trigeminal nerve.