bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between serum albumin and prostate-specific antigen: A analysis of the National Health and Nutrition Examination Survey, 2003–2010
Authors: Xu Kailiang , Yan Youji , Cheng Cong , Li Shiqin , Liao Yixiang , Zeng Jinmin , Chen Zhongjun , Zhou Jiajie 
Published: March 2023

BackgroundPrevious studies have shown that serum albumin is associated with prostate cancer (PCa), but not with prostate-specific antigen (PSA) levels in populations without PCa history. Therefore, we analyzed secondary data provided by the National Health and Nutrition Examination Survey (NHANES) (2003–2010).MethodsIn total, 5,469 participants were selected from the NHANES database (2003–2010). Serum albumin and PSA levels were serially considered independent and dependent variables, serially. A number of covariates were included in this study, including demographic, dietary, physical examination, and comorbidity data. Using weighted linear regression model and smooth curve fitting, the linear and non-linear relationship between serum albumin and PSA was investigated.ResultsAfter modulating underlying interference factors, the weighted multivariate linear regression analysis revealed that serum albumin did not independently predict PSA levels (β = −0.009 95%CI: −0.020, 0.002). Nevertheless, a non-linear relationship was found between serum albumin and PSA, with a point of 41 g/L. Left of the inflection point, the effect size, 95%CI, and P-value were 0.019 (log2 transformation) (−0.006, 0.043) and 0.1335, respectively. We found a negative association between serum albumin and PSA on the right side of the inflection point, with effect size, 95%CI, and a P-value of −0.022 (log2 transformation) (−0.037, −0.007), 0.0036.ConclusionIn summary, serum albumin and PSA levels are not linearly related. When serum albumin levels exceed 41 g, serum albumin levels are negatively associated with PSA levels.
Intensity and lag-time of non-pharmaceutical interventions on COVID-19 dynamics in German hospitals
Authors: Montcho Yvette , Klingler Paul , Lokonon Bruno Enagnon , Tovissodé Chénangnon Frédéric , Glèlè Kakaï Romain , Wolkewitz Martin 
Published: March 2023

IntroductionEvaluating the potential effects of non-pharmaceutical interventions on COVID-19 dynamics is challenging and controversially discussed in the literature. The reasons are manifold, and some of them are as follows. First, interventions are strongly correlated, making a specific contribution difficult to disentangle; second, time trends (including SARS-CoV-2 variants, vaccination coverage and seasonality) influence the potential effects; third, interventions influence the different populations and dynamics with a time delay.MethodsIn this article, we apply a distributed lag linear model on COVID-19 data from Germany from January 2020 to June 2022 to study intensity and lag time effects on the number of hospital patients and the number of prevalent intensive care patients diagnosed with polymerase chain reaction tests. We further discuss how the findings depend on the complexity of accounting for the seasonal trends.Results and discussionOur findings show that the first reducing effect of non-pharmaceutical interventions on the number of prevalent intensive care patients before vaccination can be expected not before a time lag of 5 days; the main effect is after a time lag of 10–15 days. In general, we denote that the number of hospital and prevalent intensive care patients decrease with an increase in the overall non-pharmaceutical interventions intensity with a time lag of 9 and 10 days. Finally, we emphasize a clear interpretation of the findings noting that a causal conclusion is challenging due to the lack of a suitable experimental study design.
Knowledge and attitudes of health care workers about monkeypox virus infection in Southern Italy
Authors: Miraglia del Giudice Grazia , Della Polla Giorgia , Folcarelli Lucio , Napoli Annalisa , Angelillo Italo Francesco ,   The Collaborative Working Group
Published: March 2023

BackgroundThis present survey sought to investigate the level of knowledge and the attitudes pertaining the monkeypox (mpox) virus infection among a sample of health care workers (HCWs) in Italy, as well as the possible role of different factors on these outcomes.MethodsThe cross-sectional survey was performed from July through October, 2022 at four randomly selected hospitals located in Southern Italy.ResultsThe questionnaire was completed by 421 HCWs, for an overall 59% response rate. Less than two-thirds were able to define the disease and the correct answer of the transmission mechanisms ranged from 22.8% for contact with contaminated objects to 75.8% through close contact with body fluids. Only 4% and 12.8% indicated HCWs and elderly/frail/people with underlying immune deficiencies as risk groups. The mean overall score of the knowledge assessment on mpox was 3.4 (0–9). The multivariate logistic regression analysis showed that HCWs with a lower number of years of working experience and those who had acquired information about mpox from scientific journals were more likely to have a higher level of knowledge. The average score of the perception of the severity of the disease was 6.3. A similar score with a value of 6.1 has been observed for the statement that mpox is a serious problem for the population. Regarding the level of concern about contracting mpox, the mean score was 5.1. Only 10.5% reported that they feel that this disease can be prevented, with an overall mean score of 6.5. Almost all HCWs reported that they are still living as usual, with no modification of their behavior for fear of contracting the mpox. The results of the multivariate logistic regression model showed that women, HCWs with a higher level of knowledge about mpox, and those who needed additional information about mpox were more likely to have a higher level of perception of the severity of the disease.ConclusionThis survey has demonstrated that HCWs had an unsatisfactory level of knowledge toward mpox and only nearly half showed positive attitudes. Strategic health training programs should be made so that knowledge can be acquired.
Cost-effectiveness analysis of ceftazidime-avibactam as definitive treatment for treatment of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
Authors: Kong Wenqiang , Yang Xueting , Shu Yunfeng , Li Shiqin , Song Bihui , Yang Kun 
Published: March 2023

BackgroundCeftazidime-avibactam (CAZ-AVI) is a novel antibiotic that has been confirmed in the United States and China for use in patients with carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection (BSI). However, the cost-effectiveness of CAZ-AVI is unknown in China. This study aimed to evaluate the cost-effectiveness of CAZ-AVI compared to polymyxin B (PMB) monotherapy or PMB-based therapy for the treatment of CRKP BSI from the Chinese healthcare perspective.MethodsA hybrid decision tree and Markov model were constructed for a hypothetical cohort of patients with CRKP BSI. The time horizon of the Markov model was 5 years with an annual discount rate of 5% used in both costs and quality-adjusted life-years (QALYs). The model data was derived from published literature and publicly available database. Regimens with an incremental cost-effectiveness ratio (ICER) lower than the willingness-to-pay (WTP) threshold of $ 11,600 per QALY were considered cost-effective. Deterministic and probabilistic sensitivity analyses were performed to examine the robustness of model analysis.ResultsIn the base-analysis, CAZ-AVI provided an additional 60 QALYs and reduced the cost by $ 2,218,300, yielding an ICER of $ −36,730.9/QALY, well below the WTP threshold of $ 11,600 per QALY when compared with PMB-based therapy. CAZ-AVI provided an additional 350 QALYs and increased the cost of $ 208,400, producing an ICER of $ 591.7/QALY that was below the WTP threshold compared to PMB monotherapy. At a $ 11,600/QALY threshold, results were sensitive to the cost of PMB-based strategy, the cost of CAZ-AVI strategy, the probability of cure with CAZ-AVI, and the probability of cure with PMB or PMB-based therapy. CAZ-AVI was an optimal regimen in 76.9% and 80.8% of 10,000 Monte Carlo simulations at $ 11,600/QALY and $ 34,800/QALY, respectively. Meanwhile, CAZ-AVI was cost-effective at the WTP thresholds of all 31 Chinese provinces in 61.4% (Gansu) to 83.1% (Beijing) of simulations.ConclusionsCeftazidime-avibactam is expected to be a cost-effective treatment compared with PMB monotherapy or PMB-based therapy for CRKP BSI from the Chinese healthcare perspective.
Culture intelligent workflow, structure, and steps
Authors: Henry James Andrew 
Published: March 2023

IntroductionTechnologies abstract intelligence and provide predictor and precision insight in workflows that manage disorders, similar to cardiology and hematological disease. Positive perceptions of Artificial Intelligence (AI) that support Machine Learning (ML) and Deep Learning (DL) manage transformations with a safe system that improves wellbeing. In sections, workflow introduces an eXamination (X = AI) as an end-to-end structure to culture workstreams in a step-by-step design to manage populace health in a governed system.MethodTo better healthcare outcomes, communities and personnel benefit from an explanation and an interpretive that elucidates workflow for citizens or practitioners to comprehend personalized platforms. Therefore, the author undertook structure and practice reviews and appraised perspectives that impact the management of AI in public health and medicine.ResultsFigures for the management of AI workflow illustrate and inform on the model, structure, culture, assurance, process steps, values, and governance required for abstract insights in public health and medicine. The papers' end-to-end structure with explanans in a work culture interprets the step-by-step designs that manage the success of AI. Personalized care graphics offer an explanandum in the management of biological analytic value.DiscussionHealthcare leadership collaboratives plan population health with an upstream, workplace and workstream format. Secure workflow and safety wellbeing system requirements prove that genomics and AI improve medicine. Therefore, the paper discusses group understanding of current practice, ethics, policy, and legality.Conclusion“Culture, intelligent workflow, structure, and steps” improve wellbeing with personalized care and align a percept for national opportunities, regional control, and local needs. Personalized practice cultures support analytic systems to describe, predict, precision, and prescript medicine in population health management eXaminations.
The influence of flavoring components on the physicochemical properties of spray-dried high oleic (HO) and tofu line (TL) soymilk powder
Authors: Singh P. , Krishnaswamy K. 
Published: March 2023

Graphical AbstractGraphical representation of flavoring component integration in soymilk and spray dried to investigate the impact of flavoring components on the physicochemical parameters of a soymilk powder.
Strategies to reduce low-value care – An applied behavior analysis using a single-case design
Authors: Ingvarsson Sara , Sandaker Ingunn , Nilsen Per , Hasson Henna , Augustsson Hanna , von Thiele Schwarz Ulrica 
Published: March 2023

IntroductionImplementation science has traditionally focused on the implementation of evidence-based practices, but the field has increasingly recognized the importance of addressing de-implementation (i.e., the process of reducing low-value care). Most studies on de-implementation strategies have used a combination of strategies without addressing factors that sustain the use of LVC and there is a lack of information about which strategies are most effective and what mechanisms of change might underlie these strategies. Applied behavior analysis is an approach that could be a potential method to gain insights into the mechanisms of de-implementation strategies to reduce LVC. Three research questions are addressed in this study: What contingencies (three-term contingencies or rule-governing behavior) related to the use of LVC can be found in a local context and what strategies can be developed based on an analysis of these contingencies?; Do these strategies change targeted behaviors?; How do the participants describe the strategies' contingencies and the feasibility of the applied behavior analysis approach?Materials and methodsIn this study, we used applied behavior analysis to analyze contingencies that maintain behaviors related to a chosen LVC, the unnecessary use of x-rays for knee arthrosis within a primary care center. Based on this analysis, strategies were developed and evaluated using a single-case design and a qualitative analysis of interview data.ResultsTwo strategies were developed: a lecture and feedback meetings. The results from the single-case data were inconclusive but some of the findings may indicate a behavior change in the expected direction. Such a conclusion is supported by interview data showing that participants perceived an effect in response to both strategies.ConclusionThe findings illustrate how applied behavior analysis can be used to analyze contingencies related to the use of LVC and to design strategies for de-implementation. It also shows an effect of the targeted behaviors even though the quantitative results are inconclusive. The strategies used in this study could be further improved to target the contingencies better by structuring the feedback meetings better and including more precise feedback.
Analysis of the therapeutic interaction provided by a humanoid robot serving stroke survivors as a therapeutic assistant for arm rehabilitation
Authors: Platz Thomas , Pedersen Ann Louise , Deutsch Philipp , Umlauft Alexandru-Nicolae , Bader Sebastian 
Published: March 2023

Objective:To characterize a socially active humanoid robot’s therapeutic interaction as a therapeutic assistant when providing arm rehabilitation (i.e., arm basis training (ABT) for moderate-to-severe arm paresis or arm ability training (AAT) for mild arm paresis) to stroke survivors when using the digital therapeutic system Evidence-Based Robot-Assistant in Neurorehabilitation (E-BRAiN) and to compare it to human therapists’ interaction.Methods:Participants and therapy: Seventeen stroke survivors receiving arm rehabilitation (i.e., ABT [n= 9] or AAT [n= 8]) using E-BRAiN over a course of nine sessions and twenty-one other stroke survivors receiving arm rehabilitation sessions (i.e., ABT [n= 6] or AAT [n= 15]) in a conventional 1:1 therapist–patient setting. Analysis of therapeutic interaction: Therapy sessions were videotaped, and all therapeutic interactions (information provision, feedback, and bond-related interaction) were documented offline both in terms of their frequency of occurrence and time used for the respective type of interaction using the instrument THER-I-ACT. Statistical analyses: The therapeutic interaction of the humanoid robot, supervising staff/therapists, and helpers on day 1 is reported as mean across subjects for each type of therapy (i.e., ABT and AAT) as descriptive statistics. Effects of time (day 1 vs. day 9) on the humanoid robot interaction were analyzed by repeated-measures analysis of variance (rmANOVA) together with the between-subject factor type of therapy (ABT vs. AAT). The between-subject effect of the agent (humanoid robot vs. human therapist; day 1) was analyzed together with the factor therapy (ABT vs. AAT) by ANOVA.Main results and interpretation: The overall pattern of the therapeutic interaction by the humanoid robot was comprehensive and varied considerably with the type of therapy (as clinically indicated and intended), largely comparable to human therapists’ interaction, and adapted according to needs for interaction over time. Even substantially long robot-assisted therapy sessions seemed acceptable to stroke survivors and promoted engaged patients’ training behavior.Conclusion:Humanoid robot interaction as implemented in the digital system E-BRAiN matches the human therapeutic interaction and its modification across therapies well and promotes engaged training behavior by patients. These characteristics support its clinical use as a therapeutic assistant and, hence, its application to support specific and intensive restorative training for stroke survivors.
Predicting work engagement among young adult cancer survivors: A moderated mediation model
Authors: Musa Siti Nur Syuhada , Hamzah Siti Raba'ah , Muda Zulaiha , Asimiran Soaib , Krauss Steven E. 
Published: March 2023

IntroductionEarly research on cancer survivors was focused on exploring cancer treatments. More recently, attention has shifted to cancer survivorship research, focusing on cancer survivors as individual persons, including the multiple facets of survivors' quality of life but is inapplicable in the context of work-related role played in the young adult cancer survivors' lives. However, in recent studies on the outcomes of long-term survivorship, some of the main areas of cancer survivorship research revolves around employment issues of young adult cancer survivors. In the present study, the focus is given on the role of workplace spirituality as a mediator on the association of employee resilience and workplace social support on work engagement in a Malaysian setting, taking into consideration gender and age differences.MethodsUsing a quantitative research paradigm, data were collected from 270 respondents at Pediatric Institute Kuala Lumpur Hospital. Data were analyzed using descriptive statistics and the Partial Least Square-Structural Equation Model (PLS-SEM) to test the direct, indirect, and mediation effects.Results and discussionThe findings revealed that workplace spirituality did mediate the influence of employee resilience and workplace social support on work engagement. The findings also indicated that gender and age moderated the association of employee resilience and work engagement via workplace spirituality.
A future interstellar probe on the dynamic heliosphere and its interaction with the very local interstellar medium: In-situ particle and fields measurements and remotely sensed ENAs
Authors: Dialynas K. , Sterken V. J. , Brandt P. C. , Burlaga L. , Berdichevsky D. B. , Decker R. B. , Della Torre S. , DeMajistre R. , Galli A. , Gkioulidou M. , Hill M. E. , Krimigis S. M. , Kornbleuth M. , Kurth W. , Lavraud B. , McNutt R. , Mitchell D. G. , Mostafavi P. S. , Nikoukar R. , Opher M. , Provornikova E. , Roelof E. C. , Rancoita P. G. , Richardson J. D. , Roussos E. , Sokół J. M. , La Vacca G. , Westlake J. , Chen T. Y. 
Published: March 2023

The recently published Interstellar Probe (ISP) study report describes a pragmatic mission concept with a launch window that starts in 2036 and is expected to reach several hundreds of astronomical units past the heliopause within a time frame of ≥50 years (https://interstellarprobe.jhuapl.edu/Interstellar-Probe-MCR.pdf). Following the ISP report, this paper, that will also be accessible from the Bulletin of the AAS (BAAS) in the framework of the Decadal Survey for Solar and Space Physics (Heliophysics) 2024–2033 (Dialynas et al., A future Interstellar Probe on the dynamic heliosphere and its interaction with the very local interstellar medium: In-situ particle and fields measurements and remotely sensed ENAs, 2022a), aims to highlight the importance of studying the physics of the interactions pertaining to the expanding solar wind that meets the plasma, gas and dust flows of the very local interstellar medium, forming the complex and vast region of our astrosphere. We focus on three fundamental open science questions that reveal the dynamical nature of the heliosphere A) Where are the heliosphere boundaries and how thick is the heliosheath B) Is there a “missing” pressure component towards exploring the dynamics of the global heliosheath and its interaction with the very local interstellar medium C) Why does the shape and size of the global heliosphere appear different in different Energetic Neutral Atom energies? We argue that these questions can only be addressed by exploiting a combination of in-situ charged particle, plasma waves and fields measurements with remotely sensed Energetic Neutral Atoms that can be measured simultaneously from the instruments of a future Interstellar Probe mission, along its trajectory from interplanetary space through the heliosheath and out to the very local interstellar medium.
How to understand sports and traditional games and how to apply it to physical education. On the “Goal of Game”
Authors: Ribas J. P. , Hernández-Moreno J. , Díaz-Díaz R. , Borges-Hernández P. J. , Ruiz-Omeñaca J. V. , Jaqueira A. R. 
Published: March 2023

IntroductionDoes philosopher's stone exist in physical education? It could be said that teaching games for understanding approach (TGfU) keeps turning everything it touches into gold: its presence in the educational centers, its volume of publications, the way of teaching games and sports, its connections with other approaches, its game categories, learning transferable principles of play. But… no, all that glitters is not gold. There are TGfU issues that should be improved. For example, these categories are disconnected from each other because TGfU lacks classification criteria. The “goal of game” is a concept that has been studied, but it has not been applied to physical education. The aim of the article is to show how to deepen the understanding sports and traditional games from the “goal of game”, and to propose its applicability to physical education.MethodsThe traits of “goal of game” will be identified by investigating two close concepts, “prelusory goal” (formalist philosophy of sport) and “motor-goal” (motor praxeology).ResultsThe traits of “goal of game” concept: main-motor-problem, described in the game rules and that the players will try to solve during the game dynamics. The “goal of game” chances: (1) It allows us to understand sports and traditional games based on their internal logic (2) It allows us to classify traditional games and sports based on classification criteria and that can be useful to organize the physical education program; (3) It allows us to deepen the understanding of sporting games and their applicability to physical education: on the one hand, proposing progressively more specific goal of game options and, on the other hand, proposing a network model of intentions of play to understand the game dynamics and to design learning tasks.ConclusionsThe conclusions collect some properties of the “goal of game” concept in order to propose its applicability in physical education students learning: identify and compare the main-motor-problems of the games; solve these problems during the game dynamics; transfer the procedures used to solve other games. The goal(d) of game amazes us; maybe physical education teachers are curious to continue discovering this wonderful treasure.