bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children
Authors: Seijbel Thomas C. , Hoste Levi , Buysse Corinne M. P. , Dulfer Karolijn , Haerynck Filomeen , de Hoog Matthijs , Ketharanathan Naomi 
Published: January 2025

OBJECTIVES:
The COVID-19 pandemic gave rise to uncertainty concerning potential sequelae related to a severe acute respiratory syndrome coronavirus 2 infection. This landscape is currently unfolding with studies reporting sequelae on various domains (physical, cognitive, and psychosocial), although most studies focus on adults or only one domain. We sought to investigate concurrent sequelae on multiple domains 1 year after PICU admission for Multisystem Inflammatory Syndrome in Children (MIS-C).

DESIGN:
Prospective cohort study.

SETTING:
Two academic, tertiary referral hospitals in The Netherlands and Belgium.

PATIENTS:
Patients (< 18 yr, n = 58) seen in-person 1-year after PICU admission for MIS-C.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Seventy MIS-C patients (62% male; median age, 10.0 [interquartile range, 7.4–13.0]) were admitted to the PICU, mostly (86%) due to (imminent) circulatory failure. The majority received IV immunoglobulins (95%), steroids (83%), and vasopressors and/or inotropes (72%). Invasive respiratory support and extracorporeal membrane oxygenation were necessary in 7% and 2%, respectively. All patients survived. Fifty-eight patients (83%) attended 1-year follow-up. Although most patients had normal functional performance scores (Pediatric Cerebral Performance Category, Pediatric Overall Performance Category, and Functional Status Score), 62% still experienced physical sequelae: fatigue (40%), headaches (27%), and decreased exercise tolerance (19%). Cognitive, behavioral, and psychological problems were reported in 14%, 13%, and 23%, respectively. This resulted in 22% requiring ongoing healthcare utilization, 9% not being able to return to full-time school attendance and cessation of hobbies in 7%.

CONCLUSIONS:
This is the first 1-year outcome study of MIS-C PICU patients to include both physical and psychosocial characteristics. One year after PICU admission, most children had normalized functional performance as measured by three validated performance scores. However, many still reported a variety of multidimensional sequelae at 1-year follow-up impacting daily life. This emphasizes the importance of continued investigative efforts and multidisciplinary follow-up programs to better understand pathophysiology and contributing factors to the MIS-C disease trajectory and initiate patient-specific interventions to improve outcome and social participation.
Diagnostic Accuracy of Rapid Antigen Tests for Trichomoniasis: A Meta-analysis
Authors: Hsiao Ke-Yu , Lin Hsiu-Ling , Chen Hui-Mei , Chen Cheng-Chieh 
Published: January 2025

Objective
Trichomoniasis is a globally prevalent sexually transmitted infection caused by the protozoan Trichomonas vaginalis. Polymerase chain reaction (PCR) is the gold standard for diagnosing trichomoniasis, but it is expensive. Antigen tests are immunochromatographic immunoassays that detect T. vaginalis membrane proteins. Despite being user-friendly and rapid, the diagnostic accuracy of antigen tests remains uncertain. Therefore, this meta-analysis aimed to evaluate the diagnostic accuracy of antigen tests for T. vaginalis infections.

Materials and Methods
We mined the PubMed, Embase, and Cochrane Library databases for studies evaluating the diagnostic accuracy of antigen tests for T. vaginalis. We included studies that provided diagnostic test accuracy data in order to conduct a meta-analysis. We evaluated antigen tests based on immunochromatography and lateral flow devices. The meta-analysis was conducted by using the hierarchical summary receiver operating characteristic model.

Results
Eleven studies with 5,884 samples were included. The meta-analysis yielded a pooled sensitivity of 87.0% and a pooled specificity of 98.3%. A subgroup analysis employing PCR as the reference standard yielded a sensitivity of 58.5%, whereas another subgroup analysis using culture returned a sensitivity of 95.9%. The subgroup analysis of 6 studies comprising 2,328 specimens from symptomatic individuals yielded a pooled sensitivity of 85% and a specificity of 99.9%.

Conclusions
The antigen tests exhibited high sensitivity and specificity. Additionally, subgroup analyses revealed that antigen tests demonstrated greater sensitivity in diagnosing symptomatic patients compared to asymptomatic individuals. While less sensitive than PCR, antigen testing remains a promising avenue for detecting T. vaginalis infections.
The role of 18F-FDG PET/CT in detecting recurrence and metastasis in posttreatment nasopharyngeal carcinoma patients with elevated Epstein–Barr virus DNA
Authors: Su Shuting , Wang Ge , Ye Xiuhuan , Wang Hao , Chen Yuxuan , Song Shaoli , Yang Zhongyi 
Published: January 2025

Objective
The objective of this study is to evaluate and compare the clinical utility of 18F-fluoro-2-deoxy-d-glucose PET and computed tomography (18F-FDG PET/CT) in detecting recurrence and metastasis in patients with nasopharyngeal carcinoma (NPC) who exhibit elevated levels of Epstein–Barr virus (EBV) DNA following treatment.

Methods
A total of 103 patients with NPC were studied retrospectively. All patients were in remission following initial treatment. Elevated EBV DNA was found for the first time at review and 18F-FDG PET/CT imaging was completed. The number of tracer lesions and the maximum standardized uptake value in the body region were recorded to evaluate the diagnostic ability of 18F-FDG PET/CT. The final diagnosis was confirmed either through pathology or clinical follow-up lasting 6 months or longer.

Results
Out of the 103 patients, 97 patients had a total of 434 lesions that were ultimately diagnosed as recurrent or metastatic. In patient-based analyses, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 18F-FDG PET/CT imaging were 100%, 50%, 97%, and 100%, respectively. In lesion-based analyses, the sensitivity, specificity, PPV, and NPV of 18F-FDG PET/CT imaging were 99.3%, 30.3%, 94.9%, and 83.3%, respectively.

Conclusion

18F-FDG PET/CT demonstrates potential value in detecting recurrence and metastasis of NPC.
Barriers and Facilitators of Implementing Colorectal Cancer Screening Management in China
Authors: Shi Bingzi , Zhang Jing , Zhang Yasi , Sun Yujing , Xu Chen , Cui Wenming 
Published: January 2025

Background
Colorectal cancer is a major cause of cancer-related deaths in China. Timely screening is essential for reducing mortality, but implementing comprehensive programs in Chinese healthcare settings is challenging.

Objective
This study identifies barriers and facilitators to colorectal cancer screening (CRCS) in China and recommends effective implementation strategies.

Methods
Conducted from October 2023 to April 2024, this mixed-methods study under the Consolidated Framework for Implementation Research involved 128 practitioners and 440 residents near 5 community health centers and 4 tertiary care hospitals in Harbin, Heilongjiang Province. Quantitative data were analyzed using descriptive statistics and logistic regression, whereas qualitative data from 21 practitioners and 23 community members underwent directed content analysis.

Results
The study identified 18 facilitators and 29 barriers to CRCS implementation in China, analyzed across 5 Consolidated Framework for Implementation Research domains: innovation (2 facilitators, 5 barriers), outer setting (5 facilitators, 4 barriers), inner setting (3 facilitators, 4 barriers), individual characteristics (5 facilitators, 11 barriers), and implementation process (3 facilitators, 5 barriers).

Conclusion
This study highlights critical facilitators and barriers from the perspectives of healthcare professionals and the screening-eligible population. It suggests strategies to enhance early CRCS initiatives in China, including regular training, public education, financial support, and improved accessibility.

Implications for Practice
The findings from this study provide actionable insights for enhancing the implementation of CRCS in Chinese healthcare settings.
Predictors of Resilience in Prelicensure Nursing Faculty
Authors: Jones Hope E. , Beebe Lora Humphrey 
Published: January 2025

Background:
Nursing faculty vacancies reduce the numbers of students entering the nursing profession, exacerbating the health care workforce crisis. Resilience, known to mitigate occupational burnout, may play a role in retaining existing prelicensure nursing faculty (PNF), a population that has not been extensively studied.

Purpose:
We examined compassion satisfaction (CS), perceived support (PS), and associated demographic factors of resilience among PNF.

Methods:
This cross-sectional study used a secondary data analysis of survey responses from 499 PNF. Multiple linear regression analyses were conducted to identify significant predictors of resilience.

Results:
Multivariate analysis revealed CS and PS were significant predictors of resilience when controlling for age, with CS being the strongest predictor in the regression model.

Conclusions:
This study highlights the importance of CS and PS in fostering resilience among PNF. Understanding these factors can guide academic institutions in developing interventions to retain nursing faculty, thereby addressing the broader nursing shortage.
Nutritional Changes to Improve Female Fertility: Role of Obesity, Hormones, Dietary Patterns and Endocrine Disrupting Chemicals
Authors: Noguera-Navarro Clara , Candela-González Joana , Orenes-Piñero Esteban 
Published: January 2025

Importance
Infertility affects around 180 million people in the world and can be influenced by a number of nutritional factors.

Objective
The idea of a pretreatment optimization including beneficial weight loss, adequate physical activity, and good lifestyle habits could enhance fertility for many couples who want to conceive a baby.

Results
There are different aspects related to nutrition, such as obesity (affecting 23%–30% of reproductive-aged women), dietary patterns (type of diet, good or bad habits, and physical activity), nutrients (vitamins or minerals), hormones (adipokines, among others), and endocrine-disrupting chemicals (phytoestrogens and bisphenol A, among others) that have a clear impact on women’s fertility.

Evidence Acquisition
Findings have shown that a Mediterranean or balanced diet with an adequate weight loss in case of obesity and an appropriate serum concentration of different nutrients with low endocrine-disrupting exposure could improve female fertility. In addition, the context is quite important, as there are many differences between overweight and low-weight women, and both can encounter difficulties conceiving.

Conclusions and Relevance
The aim of this review is to elucidate the impact of obesity and hormones in women’s fertility. In addition, how dietary patterns could help people to increase probability of conception and birth using less fertility treatments cycles will be also analyzed. Moreover, the role of endocrine-disrupting chemicals, pollutants, and contaminants will be discussed.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning objectives
After completing this activity, the learner will be better able to discuss how obesity and hormones impact fertility; explain the role of dietary patterns regarding conception and birth; and describe the effect of endocrine-disrupting chemicals, pollutants, and contaminants.
Preoperative Anemia Prior to Gynecologic Surgery Is Associated With Increased Healthcare Costs
Authors: Murji Ally , Lam Melody , Shirreff Lindsay , Lipscombe Lorraine , Isaranuwatchai Wanrudee 
Published: January 2025

(Abstracted from J Minim Invasiv Gynecol 2024;31:778.e1–786.e1
Current guidelines state that preoperative anemia is a risk factor for adverse outcomes such as perioperative blood transfusion, surgical site infection, prolonged hospital stay, and hospital readmission after myomectomy or hysterectomy. Though standardized guidance states that this should be addressed prior to surgical procedures, it has been reported that as many as 1 in 5 patients having hysterectomies or myomectomies for benign causes is anemic at the time of their procedure.
Smoking and Risks Contributing to COVID-19 Hospitalization in Washoe County, Nevada, 2020-2021
Authors: Williams Danika M. , Lu Minggen , Weber Ann M. , Cook Daniel M. , Wang Lingchen , Yang Wei 
Published: January 2025

Objectives:
To investigate the association between smoking behavior and COVID-19 hospitalization, integrating individual and regional factors such as community resilience and social determinants of health (SDOH), addressing gaps in existing research.

Design:
Retrospective cohort study utilizing multilevel analytical methods to evaluate the effects of individual smoking status and regional SDOH on COVID-19 hospitalization.

Setting:
Washoe County, Nevada, during the first year of the COVID-19 pandemic (March 5, 2020, to April 30, 2021).

Participants:
All reported laboratory-positive COVID-19-infected adult residents of Washoe County collected by the Washoe County Health District through mandated disease surveillance for which smoking status was recorded, totaling 10,215 cases after data cleaning.

Main Outcome Measure:
Hospitalization among those with COVID-19 was the primary outcome measure, analyzed in relation to individual smoking status and zip code tabulation area (ZCTA)-level SDOH variables.

Results:
The analysis found that individuals infected with COVID-19 who currently and formerly smoked had significantly higher odds of hospitalization compared to those who never had smoked, with odds ratios adjusted for demographics and comorbidities. An increased odds of hospitalization among those with COVID-19 were associated with higher local unemployment, a significant ZCTA-level factor.

Conclusions:
Smoking may have increased the odds of hospitalization among those infected with COVID-19, as well as the socioeconomic factor of unemployment. The integration of SDOH into the assessment of health outcomes underscores the need for targeted public health interventions that address both individual behaviors and community-level factors. Future research should continue to explore these factors to inform more effective public health strategies and policy decisions.
Senility-Related Mortality in the United States During the COVID-19 Pandemic
Authors: Soin Sabrina , Mouhaffel Rama , Nhat Pham Hoang , Sainbayar Enkhtsogt , Abdelnabi Mahmoud , Ibrahim Ramzi 
Published: January 2025

Context:
Senility has been shown to negatively impact health outcomes. While national stressors have altered death trajectories for numerous diseases, little is known about the impact of the COVID-19 pandemic on senility-related outcomes.

Objective:
To evaluate the impact of the COVID-19 pandemic on senility-related mortality in the United States.

Design, Setting, and Participants:
This is a retrospective analysis of US decedents with documented senility-related death using the CDC WONDER database. We estimated annual trends in senility-related age-adjusted mortality rates (AAMR) from 1999 to 2020 using log-linear regression models. Calculation of excess deaths attributable to the COVID-19 pandemic was completed by comparison of actual 2020 mortality rates and estimated 2020 mortality using average annual percentage changes.

Results:
A total of 510 819 senility-related deaths were identified. AAMR declined by 9.76%, from 7.48 in 1999 to 6.75 deaths per 100 000 in 2020. Year 2020 showed a marked increase in mortality, with 1.13 excess deaths per 100 000 population attributable to the COVID-19 pandemic. The COVID-19 pandemic contributed to an additional burden of mortality across both sexes, resulting in an estimated 1.18 and 0.99 per 100 000 excess deaths among females and males, respectively. The excess death rates per 100 000 for Black, White, Asian/Pacific Islander, and American Indian/Alaska Native populations were 1.84, 1.05, 0.99, and 1.16, respectively. The impact on US census regions was reflected in excess death rates, with the Northeastern, Midwestern, Southern, and Western regions seeing 1.27, 1.27, 1.39, and 0.31 excess deaths per 100 000, respectively.

Conclusions:
These findings suggest that the pandemic had an association with excess senility-related mortality. Further investigation is warranted to identify factors that impact senility-related outcomes.
Recent Advancements and Future Perspectives on Molecular Biomarkers in Adult Lower-Grade Gliomas
Authors: Fleming Jessica L. , Chakravarti Arnab 
Published: January 2025

Abstract
There has been a significant paradigm shift in the clinical management of lower-grade glioma patients given the recent updates to the 2021 World Health Organization classification along with long-term results from randomized phase III clinical trials. As a result, we are now better able to diagnose and assign patients to the most appropriate treatment course. This review provides a comprehensive summary of the most robust and reliable molecular biomarkers for adult lower-grade gliomas and discusses current challenges facing this patient population that future correlative biology studies combined with advancements in technologies could help overcome.
The Impact of International Fellowship on Research Productivity
Authors: James Andrew J. , Dean Yomna E. , Savitz Benjamin L. , Sullivan Lauren E. , Saad Mariam , Torres-Guzman Ricardo A. , Abbott Erin N. , Cornely Ronald M. , Gutama Barite W. , Alter Noah E. , Bhandari Panambur L. 
Published: January 2025

Abstract
International medical graduates (IMGs) represent a significant portion of the US physician workforce, comprising 25% across all specialties with a strong presence in internal medicine and primary care. However, their representation in plastic surgery remains limited at only 10%. Matching into a US plastic surgery residency is highly competitive for both US medical graduates and IMGs. This study aimed to quantify and identify trends in academic contributions from IMGs applicants in a plastic surgery residency program over the past 13 years, hypothesizing that IMG applicants have increasingly contributed to collaborative research projects.
Data from National Resident Matching Program annual reports were analyzed, focusing on publications, research experience, and match status. An analysis of variance revealed significant differences between US MDs and IMGs in terms of publications and research experience. IMGs had a higher number of publications and work experience compared to matched US MDs, while US MDs had more research experiences than IMGs.
The findings underscore the importance of research for IMGs, who often engage in additional research experiences to enhance their competitiveness for residency positions. The study showed that IMGs have a greater research output, contributing significantly to academic publications within the plastic surgery field. This productivity benefits the IMGs in securing residency positions and enriches the academic research environment of the residency programs.
IMGs bring unique perspectives and innovative approaches to research, often collaborating internationally, which enhances the scope and quality of research projects. Their contributions are vital to the advancement of plastic surgery and the broader medical field. As the demand for physicians in the US grows, integrating IMGs into the healthcare system through strategic inclusion in research and clinical training is essential. This study highlights the critical role of IMGs in driving medical research and underscores the need for supportive policies to facilitate their integration into the US healthcare workforce.
Early Cold Stored Platelet Transfusion Following Traumatic Brain Injury
Authors: Neal Matthew D. , Okonkwo David O. , Guyette Francis X. , Luther James F. , Vincent Laura E. , Puccio Ava M. , Harner Ashley M. , Agnone Allison G. , Brubaker Donovan P. , Love Emily T. , Leeper Christine M. , Brown Joshua B. , Forsythe Raquel , Spinella Philip C , Yazer Mark H. , Wisniewski Stephen R. , Sperry Jason L. ,   and the Cold Stored Platelet for Traumatic Brain Injury (CRISP-TBI) study group
Published: January 2025

Objective:
To determine the feasibility, efficacy, and safety of cold stored compared to room temperature platelet transfusion in patients with traumatic brain injury.

Summary Background Data:
Data demonstrating the safety and efficacy of cold stored platelet transfusion are lacking following traumatic brain injury.

Methods:
A phase 2, randomized, open label, clinical trial was performed at a single U.S. trauma center. Traumatic brain injured patients with positive brain imaging and a need for platelet transfusion received up to two apheresis units of cold stored platelets stored out to 14 days versus standard care room temperature platelet transfusion. The primary outcome was feasibility and the principal clinical outcome for efficacy and safety was the 6-month Glasgow Coma Scale-Extended score.

Results:
The 6-month Glasgow Outcome Scale-Extended score distributions were not different across cold stored and room temperature platelet arms (OR-1.58, 95%CI 0.71 to 3.54, P=0.27). A lower rate of neurosurgical craniotomy/craniectomy was found for those receiving cold stored platelets (difference -14.4%, 95%CI -26.5% to -2.3%, P=0.03). Adverse event rates did not differ across groups. The storage age of the cold stored product was not associated with outcome differences.

Conclusions and Relevance:
In brain injured patients requiring platelet transfusion, early cold stored platelet transfusion is feasible, and did not result in improved 6-month Glasgow Coma Scale-Extended scores. Early cold stored platelet transfusion was associated with a lower rate of neurosurgical operative intervention without an increase in adverse events. The storage age of the cold stored platelet product was not associated with outcome differences. Future phase 3 clinical trials are required to determine clinical outcome differences and safety attributable to cold stored platelet transfusion following traumatic brain injury.
A new conceptual model for seed germination and seedling tillering of winter wheat in the field
Authors: Chen Jinping , Whalley Peter A. , Li Zhongyang , Zhang Xiaoxian , Hawkesford Malcolm J. , Whalley W. Richard 
Published: January 2025

Seed germination is a crucial stage in plant development, intricately regulated by various environmental stimuli. Understanding these interactions is essential for optimizing planting and seedling management but remains challenging due to the trade-off effects of environmental factors on the germination process. We proposed a new conceptual model by viewing seed germination as a dynamic process in a physiological dimension, with the influence of environmental factors and seed heterogeneity characterized by a germination speed and a dispersion coefficient. To validate the model, we conducted field experiments by drilling wheat seeds at different dates to establish a temperature gradient and in different plots to create a soil water content gradient. Comparisons with our experimental data and literature results show the model accurately reproduces all germination patterns and the subsequent seedling tillering, with
R
2
> 0.95. Our results reveal that within suboptimal temperature range, the seed germination increases asymptotically with temperature, and that as soil water content increases, the germination speed increases initially before decreasing, illustrating the trade-off effect of soil water on bioavailability of water and oxygen. Introducing a physiological dimension enables seed germination and the subsequent tillering process to be modelled as a continuous physiological process, providing deeper insight into plant growth dynamics.