bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint disaster relief: The Chinese Civilian Rescue Teams' response to the 2021 Henan Flood
Authors: Lu Yi , Gan Yutong , Zhang Zhiyue 
Published: June 2023

Abstract
In China, the involvement of civilian rescue teams (CRTs) in emergency-response has continued to grow and has progressively developed as an effective complement to the government’s emergency management system. However, their emergency-response mechanisms, functions, and networks have not been extensively studied. Based on an empirical case study of the 2021 Henan flood, this study employed a mixed methods research model, combining in-depth interviews with social network analysis (SNA) to investigate the mechanism and functions of CRTs and analyse the joint relief networks involving these teams. The CRT emergency-response mechanism comprised five phases: assessment, preparation, mobilisation, operation, and review. The main emergency support functions of CRTs were searching for and rescuing people and transferring and distributing rescue supplies. In the CRT joint relief network, government agencies retain their dominant emergency management positions, with the frontline coordination centre playing a key role in integrating relief information and acting as a bridge between CRTs, local governments, and disaster areas. These research results can motivate CRTs to improve their capabilities, thereby increasing the efficiency and quality of their joint disaster responses. Furthermore, these findings can assist governments in formulating more effective emergency-response management policies and promote cooperation between CRTs and government entities.
Evaluation of Low-Cost Sensors for PM2.5 Monitoring: Performance, Reliability, and Implications for Air Quality Assessment
Authors: Kurniawati Syukria , Santoso Muhayatun , Nurhaini Feni Fernita , DA Djoko Prakoso , Lestiani Diah Dwiana , Ramadhani Moch. Faizal , Kusmartini Indah , Syahfitri Woro Yatu Niken , Damastuti Endah 
Published: June 2023

Abstract
PM2.5 become people’s concern due to its health effect and its presence in the air that reduce visibility when levels are raised. Therefore, monitoring of PM2.5 level is essential for assessing the level as well as the variability. In this study, the low-cost sensor Purple Air was utilized for PM2.5 monitoring. Evaluation of the low-cost sensor was done by co-location sampling with the filter-based Super Speciation Air Sampling System (Super SASS) instrument as the Federal Reference Method (FRM). The low-cost data during June 2022 - May 2023 were compared to the data from Super SASS. Sampling was done in Tamansari Bandung, Indonesia. The average mass concentration of PM2.5 from the low-cost sensor was 39.04±15.16 mg/m3. The comparative results of the two methods were obtained with a coefficient of determination value of 0.96. An average ratio of 1.24 shows that the concentration of PM2.5 from low-cost sensors is generally higher by 24% than from Super SASS. The low-cost sensor in this study was utilized for monitoring the temporal variation of PM2.5. Temperature and humidity measured by the low-cost sensor and the value obtained in the range of 26.29-33.41°C and 37.41-63.91%, respectively. The low-cost sensor shows its capability in monitoring the temporal variation of PM2.5 in Bandung, where the results indicate that PM2.5 levels are influenced by meteorological factors and emission sources. The outcomes of this study provide valuable information to authorities, enabling them to establish appropriate measures and policies to control and mitigate the impacts of air pollution on air quality.
Uplifting of anticorrosive coatings performance via TiO2 /ZnO core-shell pigment for oil and gas pipelines protection
Authors: Ahmed Nivin M. , Mohamed Mostafa G. 
Published: June 2023

Abstract
Cheap and safe ways for transportation are among the forehead crucial requirements to distribute petroleum products and natural gas to the different areas; and the most profitable method is via steel pipelines. Nonetheless these pipelines are subjected to corrosion, and therefore an economically feasible defense system is a must. Accordingly, new core-shell pigment (TiO2/ZnO) was prepared and characterized via XRD, XRF, TEM, SEM, and EDX analysis to be encountered in polymeric coating formulations, then subjected to standard corrosion experiments; including immersion test, adhesion, and electrochemical measurements. Impedance spectroscopy was hired for observing the resistance and capacitance of the coatings during 28 days. The obtained results conveyed that the prepared core-shell pigment with its unique structure can strongly enhance the resistivity of the formulated coating to protect the pipeline outer-wall from corrosion. Eventually, these results can develop the knowledge about the combination of high performance and low cost anticorrosive coatings that can be applied in high corrosive media.
Research on Propagation Characteristics of Tire Cavity Resonance Noise in the Wheel
Authors: Hu Xiaojun , Liu Xiandong , Shan Yingchun , He Tian 
Published: June 2023

Abstract

Tire cavity resonance noise (TCRN) is one of main contributors to vehicle interior noise which has been a concern in the automotive industry. As the wheel is the first part of TCRN energy propagating into the vehicle, the propagation characteristics of energy in the wheel are studied. Firstly, the finite element models of wheels (steel wheels and aluminum alloy wheels with the same type) are established, and the propagation characteristics of TCRN in steel wheels and aluminum alloy wheels are studied and compared by the power flow method. Then, the models of three aluminum alloy wheels with different spoke configurations are established, and the propagation characteristics of TCRN in different aluminum wheels are studied by the power flow method. TCRN is easier to propagate in Y-shaped wheels than in V-shaped and star-shaped wheels, while the TCRN propagation characteristics in V-shaped or star-shaped wheels are not significantly different. So the study of propagation characteristics can provide basis for aluminum alloy wheel spoke design.
Hsa_circ_0000417 downregulation promotes hypospadiac formation by modulating AR-PTEN-AKT axis
Authors: su cheng , Jia Wei , Huang Rongzhi , Huang Junqiang , Xie Qike , Ma Qianqian , Dong Jie , Lin Yingfu , Chen Chao 
Published: June 2023

Abstract
Background: Congenital hypospadias is a common congenital malformation of the urinary system in male children. To explore the mechanism of hypospadias is particularly important,because it could provide a potential guide for clinical treatment. Dysregulated apoptosis of penile mesenchymal cells has been previously demonstrated to underly hypospadiac urethral closure failure.we found hsa_circ_0000417 significantly downregulated in hypospadias preputial specimens,act as a ceRNA for AR via sequestering hsa_miR-6756-5p, and that the biological functions of hsa_circ_0000417 may significantly involve the PI3K/AKT pathway in previous reports.However, the regulatory mechanisms remain poorly unknown.
Methods: We performed study on primary culture fibroblasts from normal and hypospadias tissues in vitro.The cell apoptosis was measured by fow cytometry using Apoptosis Detection Kit,and the protein level of AR,bax, caspase 9 and AKT signaling pathway were measured by Western Blot (WB). we examined the role of hsa_circ_0000417 in vivo using the mouse model of hypospadias.
Results: The effects of hsa_circ_0000417 in foreskin fibroblasts were studied both in vitro and vivo. Functionally, knockdown of hsa_circ_0000417 influence the mesenchymal cell apoptosis whereas overexpression had the reverse effects. Mechanistically, primary culture fibroblasts and mice models were detected by flow cytometry and Western Blot (WB)，androgen receptor (AR)、cell apoptosis proteins of AKT、BAX、Caspase9 were significantly decreased expression compared with normal tissues, attenuated mesenchymal cell apoptosis. Further investigation revealed that hsa_circ_0000417 directly interacted with miR-6756. miR-6756 inhibitors had a rescue effect on the proliferation and apoptosis capacities by knockdown of hsa_circ_0000417.It suggested that hsa_circ_0000417 may regulate AR-PTEN-AKT pathway influence the apoptosis of fibroblasts.
Conclusions: Taken together,hsa_circ_0000417 functioned as a molecular sponge for miR-6756 promotes the occurrence of hypospadias through the AR-PTEN-AKT axis and may serve as a novel diagnostic marker and target for treatment of hypospadiac patients.
Comprehensive Analysis of Long Non-Coding RNAs and mRNAs Expression in Single Suture Craniosynostosis Patients
Authors: Lan Dongyi , Wang Yueqing , Zhang Songchunyuan , Liu Baihui , Ge Qianyun , Dong Chenbin 
Published: June 2023

AbstractAim To investigate the expression profile of long non-coding RNAs (lncRNAs) in closed and patent sutures from single suture craniosynostosis patients and explore their underlying functions. Methods Using a lncRNA microarray assay to determine the differential expression profile of lncRNA in sutures from three single suture craniosynostosis patients (two sagittal, one uni-coronal). We performed the functional analysis and constructed the lncRNA-mRNA co-expression network to explore the biological functions. Results There were 98 up-regulated, 125 down-regulated lncRNAs and 88 up-regulated, 122 down-regulated mRNAs identified in the closed sutures compared to the patent sutures (fold change > 1.5,P < 0.05). GO enrichment and KEGG pathway analyses indicated that altered genes enriched in “extracellular matrix,” “skeletal system development,” and “osteoclast differentiation.” The lncRNAs-mRNAs co-expression network manifested the implication of lncRNA expression profiles in single suture craniosynostosis via interactions with mRNAs. Conclusion This is a novel study to present an expression profile of lncRNAs from craniosynostosis patients. lncRNAs may play a functional role in cranial suture development and premature fusion. The results provide a new perspective on the etiology of single suture craniosynostosis.
Cardiovascular Mortality among Patients with Pancreatic Cancer: A Population-based Study
Authors: Liu Gen , Zhang Bo-fang 
Published: June 2023

Abstract
Background
With the advancements in detection and treatment, the survival rates of patients with pancreatic cancer have gradually increased. However, cardiovascular disease has become a common complication among tumor patients due to treatments. The mortality and risks of cardiovascular mortality in patients with pancreatic cancer remain unclear.
Objectives
This retrospective cohort study aimed to evaluate the mortality patterns and quantify cardiovascular mortality risk in patients with pancreatic cancer.
Methods
Data extracted from the US Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2018 were used to conduct this study. Patients aged 15 or older with a primary diagnosis of pancreatic cancer were included. The primary endpoint was the death of cardiovascular disease among pancreatic cancer patients. Standardized mortality ratios (SMRs) were compared with the general cancer population in the US. The Competing Risk model was used to assess the association between pancreatic cancer and cardiovascular disease.
Results
A total of 125,324 patients primarily diagnosed with pancreatic cancer were enrolled, with a median follow-up time of 4.0 (1.0–12.0) months. The mean age at diagnosis was 68.97 ± 12.88 years, and 62,271 (49.69%) were male. Overall, 2862 patients died of cardiovascular disease. The SMR of cardiovascular disease was 1.81 (1.74–1.88), and the highest SMR in the subtype of cardiovascular disease was atherosclerosis (2.69, 95%CI: 1.90–3.48). In the multivariable Competing Risk model, patients with older age at diagnosis and who underwent surgery were associated with higher risks of cardiovascular diseases.
Conclusions
Cardiovascular disease mortality among patients with pancreatic cancer is higher than that in the general cancer population in the US. Patients with pancreatic cancer at higher risk of cardiovascular disease need more attention.
Effect of siRNA-promoted Silencing of Prion Protein on Doxorubicin-induced Cell Death Machineries in Human Adriamycin-resistant Small Cell Lung Cancer Cell Line H69AR
Authors: Kadınşah Hayrettin , Öztel Zübeyde , Tuğrul Berrin , Balcan Erdal 
Published: June 2023

Abstract
Background
Multidrug resistance is one of major challenges in cancer therapy. Recent data have proposed that among its many cellular functions, prion protein (PrP) is also involved in the acquisition of a multidrug resistance phenotype of cancer cells. In this study, we examined the effect of PrP on doxorubicin-induced cell death in the human adriamycin-resistant small cell lung cancer cell line H69AR.
Methods
We established an experimental design with a series of groups including knockdown of PrP expression in H69AR cells by siRNA (siRNA group), doxorubicin treatment at IC50 concentration (Doxo IC50 group) and combination of siRNA transfection/doxorubicin IC50 treatment (siRNA/Doxo IC50 group). qRT-PCR and immunocytochemistry analyses were performed for PrP, CD44, Bax and Beclin-1 expressions.
Results
siRNA transfection and co-delivery of siRNA transfection/doxorubicin treatment decreased the PrP mRNA expression and immunofluorescence signals for PrP. However, doxorubicin treatment at IC50 concentration increased the PrP levels. Besides, the increased expression of CD44, Bax and Beclin-1 proteins was observed in all three groups. Monodansylcadaverine results indicated that the number of autophagic vacuoles was increased in all the experimental conditions.
Conclusions
Our results suggest that knockdown of PrP in H69AR cells may ameliorate the doxorubicin-induced cell death machineries such as apoptosis and autophagy. In conclusion, the knockdown of PrP may be an attractive strategy for the treatment of drug-resistant cancers to improve the effect of conventional chemotherapeutics.
The Influence of Light-Induced Pupil Constriction on the Vault of Implantable Collamer Lens and Its Determinants
Authors: Song Zhenhao , Li Qi , Xiong Ying , Mao Yingyan , Wang Xiaofei 
Published: June 2023

Abstract
Purpose
To investigate the change in the vault of the Implantable collamer lens (ICL) under dark-to-light conditions and its associations with anterior chamber parameters in patients who have undergone ICL surgery.
Methods
For 76 eyes from 80 patients, some anterior chamber volume (ACV), pupil diameter (PD), anterior chamber angle, central corneal thickness (CCT), white-to-white (WTW), lens thickness (LT), axial length (AL) and the patient’s age preoperatively were collected. Using anterior segment optical coherence tomography (AS-OCT), to measure postoperative vault, PD and LT under scotopic and photopic conditions and calculated the changes. Mixed-effects models were used to analyze the correlation between the vault change under dark-to-light conditions and the demographic and ocular parameters of all subjects and the high-vault subgroup.
Results
The vault under photopic condition (648.36 ± 304.47µm) was significantly smaller compared to the vault under scotopic condition (708.89 ± 316.15µm). In all patients, vault change increased with the increase of age, LT change and PD change; and increased with the decrease of ACV and baseline vault (vault under scotopic condition). In the subgroup of patients with high vault, vault change increased with the increase of CCT and PD change; and increased with the decrease of ACV.
Conclusions
The changes in ICL vault under dark-to-light conditions had a significant correlation with specific anterior segment parameters. Changes in vault were primarily due to the posterior shift of the ICL and alterations in lens thickness and position.
Effect of age and gender on ventricular-arterial coupling estimated using a non-invasive technique
Authors: Obata Yurie , Matsuki Yuka , Okafuji Kazuhiro , Shigemi Kenji 
Published: June 2023

Abstract
Background: Left ventricular-arterial coupling is assessed as the ratio of left ventricular end-systolic elastance (Ees) to arterial elastance (Ea). Previous studies have introduced non-invasive estimations of Ees/Ea. It requires only four variables, namely pre-ejection period, ejection time, end-systolic pressure and diastolic pressure. The aims of the present study were to clarify the reference values of Ees/Ea estimated using the noninvasive technique, and to investigate the effects of age and gender on Ees/Ea in healthy subjects.
Methods: This retrospective study utilized data from healthy, 30-79 year old subjects. We recorded electrocardiogram, phonocardiogram, and brachial arterial pulse waves simultaneously using the vascular screening system, and used the observed variables to calculate Ees/Ea. We separated subjects into five groups according to their age and compared Ees/Ea among the different age groups.
Results: The study included 2114 males and 2292 females. Ees/Ea ranged from 1.87 to 2.04 in males, and 1.97 to 2.32 in females. We observed no age-related differences in Ees/Ea in males (p=0.10), and significant differences in females (p<0.001). Ees/Ea in males was not different compared to those in females in 60-69 year old group. Whereas Ees/Ea was higher in females compared to those in males in the other age groups.
Conclusions: We clarified the reference values of Ees/Ea in healthy subjects. The effect of age on Ees/Ea is different in males and females, although Ees/Ea is maintained within a relatively narrow range in all subjects.
Dynamic resonance fluorescence in cavity quantum electrodynamics
Authors: Liu Jin , Liu Shunfa , Gustin Chris , Liu Hanqing , Li Xueshi , Yu Ying , Ni Haiqiao , Niu Zhichuan , Hughes Stephen , Wang Xue-Hua 
Published: June 2023

Abstract
The coherent interaction between a two-level system and electromagnetic fields serves as a foundation for fundamental quantum physics and modern photonic quantum technology. A profound example is resonance fluorescence, where the non-classical photon emission appears in the form of a Mollow-triplet when a two-level system is continuously driven by a resonant laser. Pushing resonance fluorescence from a static to dynamic regime by using short optical pulses generates on-demand emissions of highly coherent single photons. Further increasing the driving strength in the dynamical regime enables the pursuit of exotic non-classical light emission in photon number superposition, photon number entanglement, and photon bundle states. However, the long-sought-after spectrum beyond the Mollow-triplet, a characteristic of dynamic resonance fluorescence under strong driving strength, has not been observed yet. Here we report the direct observation and systematic investigations of dynamic resonance fluorescence spectra beyond the Mollow-triplet in a solid-state cavity quantum electrodynamic system. The dynamic resonance fluorescence spectra with up to five pairs of side peaks, excitation detuning induced spectral asymmetry, and cavity filtering effect are observed and quantitatively modeled by a full quantum model with phonon scattering included. Time-resolved measurements further reveal that the multiple side peaks originate from interference of the emission associated with different temporal positions of the excitation pulses. Our work facilitates the generation of a variety of exotic quantum states of light with dynamic driving of two-level systems.
Dual-Wing Ligand Constructed Metal-Organic Framework Membranes with Finely Tuned Apertures for Natural Gas Separation
Authors: Jin Jian , Shi Yapeng , Wang Zhenggong , Lai Weikang , Liao Yining , Lu Kuan , Liu Yang , Niu Zheng 
Published: June 2023

Abstract
Metal-organic framework (MOF) membranes with apparent molecular sieving effect have great potential for gas separation. However, their application in light-gas separation (e.g. CO2/CH4 and H2/CH4) remains challenging due to their enlarged pore structures under transmembrane pressure. In this work, we report a series of MOF membranes constructed from dual-wing (DW) ligands including 2-chloromethylbenzimidazole, 2-methylbenzimidazole, 2-ethylbenzimidazole, and 2-phenylbenzimidazole, to finely tune apertures and enhance molecule sieving property for small-size gases. These DW-ligands provide steric resistance in two directions perpendicular to the coordination bond, leading to a much finer pore structure. The introduction of the DW-ligands endows the DW/ZIF-8 membranes with an adjustable bottleneck door for regulating gas diffusion, blocking the transport of large-size CH4 while allowing small-size CO2 to permeate. The membranes show significantly improved molecular sieving property with separation factor of CO2/CH4 above 55 in the case of 2-chloromethylbenzimidazole23/ZIF-8 membrane, which represents the highest value among the reported MOF membranes. The membrane also exhibits exceptional separation performance for H2/CH4 and H2/C3H8 with separation factors of 430 and 34341, surpassing most of the reported MOF membranes. This study presents a facile and efficient strategy for regulating MOF aperture and constructing high-performance membranes for natural gas separation.
Ultrasensitive touch sensor for simultaneous tactile and slip sensing
Authors: Pan Caofeng , Liu Yue , Tao Juan , Mo Yepei , Bao Rongrong 
Published: June 2023

AbstractTouch is a general term to describe mechanical stimuli. It is extremely difficult to develop touch sensors that can detect different modes of contact forces due to their low sensitivity. A high sensitivity response to complex contact states, such as pressure and slip, requires effective material design strategies for the sensor sensitivity layers. In this work, an ultrasensitive piezoresistive touch sensor is developed using a one-step phase-inversion-to-film strategy along with the sacrificial template method. The spectral analysis of the output signal is performed using a wavelet transform. This enables the sensor to be used for normal pressure and slip sensing. This work confirms that an interconnected porous structure can be easily controlled using this strategy. The sensor shows an ultra-high sensitivity of 1167 kPa− 1and a low-pressure detection limit of 1.34 Pa due to its considerably low compression modulus of 23.8 Pa. A wavelet transform is used to successfully detect different contact states and identify various materials. This novel fabrication strategy and signal analysis method provides a new direction for the development of tactile/slip sensors.
Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: A two-sample bidirectional Mendelian randomization study
Authors: Wang Haikuo , Chen Xiaolin , Wang Siming , Zhang Heyun 
Published: June 2023

Abstract
Objective
To explore the underlying causal relationship between leukocyte telomere length (LTL) and four gastrointestinal diseases, we designed a two-sample bidirectional Mendelian randomization study.
Methods
Two-sample Mendelian randomization was used to explore genetic predictive causality between LTL and four gastrointestinal diseases, including irritable bowel syndrome (IBS), gastroesophageal reflux (GERD), gastrointestinal ulcers disease (GUD), and nonalcoholic fatty liver disease (NAFLD). Fixed-effect model IVW results were used as the primary outcome of MR analysis. Cochran's Q was calculated to check for heterogeneity, and MR-Egger and MR-presso were detected for pleiotropy. To increase the credibility of the findings, SNPs with a significance level of 5e-7 for selected exposure were adjusted for secondary analysis.
Results
MR analysis showed that LTL increased the incidence of IBS (OR, 95% CI: 1.002, 1.000-1.004; p = 0.040), reducing the incidence of GERD (OR, 95% CI: 0.890, 0.800 to 0.991; p = 0.033), and the conclusion was not affected by the reverse causal effect. The results of MR analysis showed that there was no potential causal relationship between the change of LTL length and the pathogenesis of PUD and NAFLD.
Conclusion
The shortening of LTL predicts a low risk of IBS and a high risk of GERD. Although changes in LTL may not be a direct cause of gastrointestinal diseases, it may be used as a biomarker for the prediction of digestive tract diseases as a potential therapeutic target.