bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Shifts
Authors: Schleifer Philip 
Published: March 2023

What global shifts in markets and power mean for the politics and governance of sustainability.
In recent years, major shifts in global markets from North to South have created a new geography of trade and consumption, particularly in the agricultural sector. How this shift affects the governance of sustainability, and thus the future of the planet, is the pressing topic Philip Schleifer takes up in this book. The processes of twenty-first-century globalization are fundamentally changing the politics and governance of commodity production, Schleifer argues, with profound implications for the environment in the food-producing countries of the Global South.
At the center of Schleifer's study are Brazil and Indonesia—two key sites of experimentation in new models of global environmental and commodity governance—where palm oil and soy supply chains have seen unprecedented degrees of private environmental governance in recent years. However, instead of transforming these industries, the diffusion of transnational sustainability standards has accompanied a worsening ecological crisis, with mounting evidence of increasingly strong links between deforestation and globalization in twenty-first-century agricultural trade. To uncover the causes of this governance failure, Schleifer develops a multi-level framework for analyzing how contemporary globalization is reconfiguring the political economies of such industries. The result is the first comprehensive analysis of the shift of global agricultural trade to the South and the deepening crisis of commodity-driven deforestation—and a complex and evolving picture of both the risks and opportunities for sustainability presented by this transformative shift.
Incorporating dietary fiber from fruit and vegetable waste in meat products: a systematic approach for sustainable meat processing and improving the functional, nutritional and health attributes
Authors: Haque Abdul , Ahmad Saghir , Azad Z. R. A. A. , Adnan Mohd , Ashraf Syed Amir 
Published: March 2023

Background
Every year, the food business produces a sizeable amount of waste, including the portions of fruits and vegetables that are inedible, and those that have reached a stage where they are no longer suitable for human consumption. These by-products comprise of components such as natural antioxidants (polyphenols, carotenoid etc.), dietary fiber, and other trace elements, which can provide functionality to food. Due to changing lifestyles, there is an increased demand for ready-to-eat products like sausages, salami, and meat patties. In this line, meat products like buffalo meat sausages and patties are also gaining the interest of consumers because of their rich taste. Meat, however, has a high percentage of fat and is totally deprived of dietary fiber, which poses severe health problems like cardiovascular (CV) and gastrointestinal diseases. The health-conscious consumer is becoming increasingly aware of the importance of balancing flavor and nutrition. Therefore, to overcome this problem, several fruit and vegetable wastes from their respective industries can be successfully incorporated into meat products that provide dietary fiber and play the role of natural antioxidants; this will slow down lipid oxidation and increase the shelf-life of meat products.

Methodology
Extensive literature searches have been performed using various scientific search engines. We collected relevant and informative data from subject-specific and recent literature on sustainable food processing of wasted food products. We also looked into the various applications of waste fruit and vegetable products, including cereals, when they are incorporated into meat and meat products. All relevant searches meeting the criteria were included in this review, and exclusion criteria were also set.

Results
The pomace and peels of fruits like grapes, pomegranates, cauliflower, sweet lime, and other citrus are some of the most commonly used fruit and vegetable by-products. These vegetable by-products help inhibit oxidation (of both lipids and proteins) and the growth of pathogenic and spoilage bacteria, all without altering the consumer’s acceptability of the product on a sensory level. When included in meat products, these by-products have the potential to improve the overall product quality and lengthen its shelf-life under certain circumstances.

Conclusion
Cost-effective and easily accessible by-products from the fruit and vegetable processing industries can be used in meat products to enhance their quality features (physicochemical, microbial, sensory, and textural aspects) and health benefits. Additionally, this will provides environmental food sustainability by lowering waste disposal and improving the food’s functional efficacy.
Lean construction: perspectivas no âmbito da construção civil brasileira
Authors: De Araújo Carlos Henrique , Guimarães Irce Fernandes Gomes , Nascimento Alessandra Bruna Silva , Andrade Pedro Artur Fernandes Lino 
Published: March 2023

A construção civil tem um papel de destaque na economia dos países, não sendo diferente na economia brasileira. Este setor é responsável por considerável movimentação financeira que impulsiona parte do desenvolvimento econômico. Sabe-se que, no referido setor, existe um grande índice de desperdício, retrabalho, necessidade de aprimoramento na organização de estoque, sequência das atividades e acompanhamento das operações. Diversos autores apresentam ferramenta lean construction para aumentar a produtividade, diminuir custos, aprimorar a execução das atividades e gerar valor por meio da análise de desperdícios nos serviços envolvidos na construção civil. Neste contexto, este artigo tem o objetivo de apresentar os resultados de uma análise preliminar de como a construção enxuta é aplicada no cotidiano de um grupo de profissionais técnicos, engenheiros, arquitetos, diretores, gerentes e outros envolvidos no setor da construção civil em uma cidade do estado de Minas Gerais.
Production of Acetic Indole Acid in Macrophomina phaseolina
Authors: Amairani Alanís-Rodríguez Lizeth , Rodríguez-Castillejos Guadalupe , Garza-Cano Efrén , Ramírez-Quintanilla Laura , Oliva-Hernández Amanda , Lizarazo-Ortega Cristian , Hernández-Mendoza José Luis 
Published: March 2023

The fungus Macrophomina phaseolina is a phytopathogen of great importance attacking various crops and causing severe losses especially in sorghum, beans, soybeans and others. Since acetic indole acid (AIA) is a hormone that some authors associate with the pathogenic power of other fungi such as Fusarium oxysporum, it was decided to perform this work to detect whether M phaseolina isolated from beans is layers of producing AIA and which synthesis pathways are involved in its production. The analyses performed using HPLC showed the production of indole acetamide (ACM) that occurs in the first 60 hours of incubation. Another compound produced is Indole (IND) which is released after 60 hours when ACM production has ceased. Similarly, the fungus can metabolize AIA in the culture medium and tryptophan, the main precursor of AIA, apparently has no effect on the amount of AIA synthesized.
Conclusion: The phytopathogenic fungus Macrophomina phaseolina can produce indole acetic acid, a hormone that stimulates plant growth through the TRP-D pathway via indole acetamide, which occurs mainly in the first 60 hours of growth of the fungus in the culture medium. In addition, the presence of indole was detected, which allows us to estimate that the fungus uses another little explored route that is TRP-I and that from this compound the AIA can be synthesized directly or transformed into TRP. This means that when a metabolic pathway of IAA is turned off (ACM) it is replaced by another pathway (Indole). The convenient is to correlate the release of indole acetic acid with the pathogenicity of M phaseolina.
Towards Positive Behaviours: An Evaluation of a Teachers’ Training on Classroom-based Interventions for Managing Problem Behaviours in Preschoolers in Nigeria
Authors: Obiejemba Ngozi , Adeniyi Yetunde C. , Omigbodun Olayinka O. 
Published: March 2023

Aim: This study was a cluster randomized trial, designed to evaluate the effect of a teachers’ training on Classroom-based Interventions for Managing Problem Behaviours in Preschoolers in Nigeria.
Methodology: A total of 110 preschool teachers participated in the study. Fifty-five were randomly assigned to each of the intervention and the wait-list groups. Participants in the intervention group received two training sessions on child behaviour problems and management. Data was collected in 3 phases; baseline, immediate post-intervention and one-month post-intervention.
Results: The proportion of participants in the intervention group who felt frustrated about managing challenging behaviours, reduced significantly (p=0.045) at follow up (14.5%) compared to baseline (32.7%). There was a statistically significant (p<0.001) increase in the proportion of those who documented problem behaviours occurring at school (72.7%) at follow up, compared to baseline (38.2%). Participants in the intervention group reported increased confidence and competence to manage problem behaviours in their classroom settings.
Conclusion: This study showed that training interventions can improve the perception, competence and skills of teachers in managing problem behaviours among preschoolers. It is recommended that preschool teachers receive training that will improve their classroom management of children with problem behaviours, even in low-income settings.
A preliminary evaluation of N-acetylcysteine's effects on patient adherence to treatment for cocaine use disorder
Authors: Schechter Jake , Brown Geoffrey W. , Janda Maria 
Published: March 2023

AbstractIntroductionCocaine use disorder (CUD) is a disabling disease associated with high rates of relapse and intense cravings. Patients with CUD struggle to adhere to treatment, which contributes to relapse and frequent readmissions to residential rehab (RR) facilities. Preliminary studies suggest that N-acetylcysteine (NAC) attenuates cocaine-induced neuroplasticity and, therefore, may assist with cocaine abstinence and adherence to treatment.MethodsThis retrospective cohort study obtained data from 20 RR facilities across Western New York. Eligible subjects were 18 or older, diagnosed with CUD, and were divided based on their exposure to 1200 mg NAC twice daily during RR. The primary outcome was treatment adherence measured by outpatient treatment attendance rates (OTA). Secondary outcomes included length of stay (LOS) in RR and craving severity on a 1 to 100 visual analog scale.ResultsOne hundred eighty-eight (N = 188) patients were included in this investigation: NAC, n = 90; control, n = 98. NAC did not significantly impact OTA (% appointments attended), NAC 68%; control 69%, (P = .89) or craving severity NAC 34 ± 26; control 30 ± 27, (P = .38). Subjects treated with NAC had a significantly longer average LOS in RR compared with controls, NAC 86 ± 30; control 78 ± 26, (P = .04).DiscussionIn this study, NAC did not impact treatment adherence but was associated with a significantly longer LOS in RR for patients with CUD. Owing to limitations, these results may not be applicable to the general population. More rigorous studies examining NAC's impact on treatment adherence in CUD are warranted.
Strategies to Improve Adherence to Skin Self-examination and Other Self-management Practices in People at High Risk of Melanoma
Authors: Ackermann Deonna M. , Bracken Karen , Janda Monika , Turner Robin M. , Hersch Jolyn K. , Drabarek Dorothy , Bell Katy J. L. 
Published: March 2023

ImportanceAdherence, both in research trials and in clinical practice, is crucial to the success of interventions. There is limited guidance on strategies to increase adherence and the measurement and reporting of adherence in trials of melanoma self-management practices.ObjectiveThis scoping review aimed to describe (1) strategies to improve adherence to self-management practices in randomized clinical trials of people at high risk of melanoma and (2) measurement and reporting of adherence data in these trials.Evidence ReviewFour databases, including MEDLINE, Embase, CENTRAL, and CINAHL, were searched from inception to July 2022. Eligible studies were randomized clinical trials of self-monitoring interventions for early detection of melanoma in people at increased risk due to personal history (eg, melanoma, transplant, dysplastic naevus syndrome), family history of melanoma, or as determined by a risk assessment tool or clinical judgment.FindingsFrom 939 records screened, 18 eligible randomized clinical trials were identified, ranging in size from 40 to 724 participants, using a range of adherence strategies but with sparse evidence on effectiveness of the strategies. Strategies were classified as trial design (n = 15); social and economic support (n = 5); intervention design (n = 18); intervention and condition support (n = 10); and participant support (n = 18). No strategies were reported for supporting underserved groups (eg, people who are socioeconomically disadvantaged, have low health literacy, non-English speakers, or older adults) to adhere to self-monitoring practices, and few trials targeted provider (referring to both clinicians and researchers) adherence (n = 5). Behavioral support tools included reminders (n = 8), priority-setting guidance (n = 5), and clinician feedback (n = 5). Measurement of adherence was usually by participant report of skin self-examination practice with some recent trials of digital interventions also directly measuring adherence to the intervention through website or application analytic data. Reporting of adherence data was limited, and fewer than half of all reports mentioned adherence in their discussion.Conclusions and RelevanceUsing an adaptation of the World Health Organization framework for clinical adherence, this scoping review of randomized clinical trials identified key concepts as well as gaps in the way adherence is approached in design, conduct, and reporting of trials for skin self-examination and other self-management practices in people at high risk of melanoma. These findings may usefully guide future trials and clinical practice; evaluation of adherence strategies may be possible using a Study Within A Trial (SWAT) framework within host trials.
Switchable Brønsted Acid‐Catalyzed Ring Contraction of Cyclooctatetraene Oxide Towards the Enantioselective Synthesis of Cycloheptatrienyl‐Substituted Homoallylic Alcohols and Oxaborinanes
Authors: Sendra Jana , Salvado Oriol , Pedrón Manuel , Reyes Efraim , Tejero Tomás , Fernández Elena , Merino Pedro , Vicario Jose L. 
Published: March 2023

AbstractThe ability of cyclooctatetraene oxide to undergo two sequential ring contraction events under mild conditions, using Brønsted acid catalysis, has been studied in detail. We have found that the selectivity can be controlled by the acidity of the catalyst and by the temperature, being able to obtain selectively either the cycloheptatriene carbaldehyde product, arising from a single ring‐contraction event, or phenylacetaldehyde that is formed after a second ring contraction process. A complete mechanistic picture of the reaction and a rationale behind the influence of the catalyst is provided based on both experimental and computational data. Finally, this acid‐catalyzed ring contraction has been coupled with an in situ enantioselective allylation reaction, delivering enantioenriched cycloheptatrienyl‐substituted homoallylic alcohols when it is carried out in the presence of a chiral phosphoric acid catalyst. These homoallylic alcohols have also been converted into enantioenriched oxaborinanes through copper‐catalyzed nucleophilic borylation/cyclization protocol.magnified image
A Cooperative Rhodium/Secondary Phosphine Oxide [Rh/P(O)nBu2] Template for Catalytic Hydrodefluorination of Perfluoroarenes
Authors: Chang Wei‐Chieh , Randel Helena , Weyhermüller Thomas , Auer Alexander A. , Farès Christophe , Werlé Christophe 
Published: March 2023

AbstractThe selective activation of C−F bonds under mild reaction conditions remains an ongoing challenge of bond activation. Here, we present a cooperative [Rh/P(O)nBu2] template for catalytic hydrodefluorination (HDF) of perfluoroarenes. In addition to substrates presenting electron‐withdrawing functional groups, the system showed an exceedingly rare tolerance for electron‐donating functionalities and heterocycles. The high chemoselectivity of the catalyst and its readiness to be deployed at a preparative scale illustrate its practicality. Empirical mechanistic studies and a density functional theory (DFT) study have identified a rhodium(I) dihydride complex as a catalytically relevant species and the determining role of phosphine oxide as a cooperative fragment. Altogether, we demonstrate that molecular templates based on these design elements can be assembled to create catalysts with increased reactivity for challenging bond activations.
Bioorthogonal Probes for Analyzing Non‐Enzymatic Post‐Translational Modifications
Authors: Shao Zhentao , Zhu Yingdi , Li Juan 
Published: March 2023

AbstractNon‐enzymatic post‐translational modifications (nPTMs) have been proposed as indicators of cellular stresses and diseases. Unfortunately, direct assessment of nPTMs in native environment is extremely challenging due to the heterogeneity of adducts and the lack of tagging tools. Given these challenges, bioorthogonal probes (BPs) have been developed for the analysis of nPTMs. The rationality is that BPs could selectively install azides or alkynes into nPTMs as a biorthogonal handle for the following enrichment or tracking. Herein, we review the state‐of‐art of BPs used for nPTMs studies, clarify their working principles, and highlight how they advance our understanding of the biological functions of nPTMs.
Inhibition of interleukin‐1 with rilonacept is not effective in cold urticaria—Results of a randomized, placebo‐controlled study
Authors: Bonnekoh Hanna , Butze Monique , Spittler Sebastian , Staubach Petra , Weller Karsten , Scheffel Jörg , Maurer Marcus , Krause Karoline 
Published: March 2023

AbstractBackgroundCold urticaria (ColdU) is characterized by pruritic wheals following exposure of the skin to cold. Many patients show insufficient response to antihistamines, the first line treatment. Based on the high efficacy of interleukin‐1(IL‐1)‐inhibition in cold‐induced urticarial autoinflammatory diseases, we assessed the effects of rilonacept, an IL‐1 inhibitor, in ColdU patients unresponsive to standard treatment.MethodsIn this randomized, double‐blind, placebo‐controlled two‐center study, we included 20 patients with ColdU. In the first part, patients received 320 mg rilonacept or placebo (1:1) followed by weekly doses of 160 mg rilonacept or placebo for 6 weeks. In the second part, all patients received weekly 160 mg or 320 mg rilonacept for 6 weeks, open‐label. The primary endpoint was change in critical temperature threshold (CTT). Secondary endpoints included changes in quality of life impairment (Dermatology Life Quality Index, DLQI), differences of inflammatory mediators upon cold provocation and safety assessment over the study period.ResultsBaseline mean CTTs were 20.2°C (placebo) and 17.3°C (rilonacept). Mean CTTs did not change significantly during the 6‐week double‐blind treatment (placebo – 0.45°C; rilonacept +0.89°C). IL‐6, IL‐18 and HSP‐70 blood levels showed interindividual variability without significant changes during hand cold water bath provocation in placebo‐ or rilonacept‐treated patients. In contrast, DLQI significantly improved in the rilonacept (mean DLQI reduction of 3.8; p = 0.002) but not in the placebo group (mean DLQI reduction of 0). Comparing baseline with the rilonacept open‐label treatment, there were no changes in CTTs or DLQI scores.ConclusionIL‐1 inhibition with rilonacept did not improve ColdU, but demonstrated a good safety profile.Clinical Trial RegistrationEudraCT number: 2012‐005726‐30. ClinicalTrials.gov identifier: NCT02171416.
Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of AGTR1+CAFs in intrahepatic cholangiocarcinoma
Authors: Li Jian‐Hui , Wu Xiao , Ni Xuhao , Li Ya‐Xiong , Xu Long , Hao Xiao‐Yi , Zhao Wei , Zhu Xiao‐Xu , Yin Xiao‐Yu 
Published: March 2023

AbstractBackgroundIntrahepatic cholangiocarcinoma (iCCA) is a highly lethal malignancy characterized by massive fibrosis and has ineffective adjuvant therapies. Here, we demonstrate the potential of angiotensin receptor blockers (ARBs) in targeting iCCA.MethodsMasson's trichrome staining was used to assess the effect of ARBs in iCCA specimens, CCK8 and gel contraction assays in vitro and in xenograft models in vivo. RNA‐seq and ATAC‐seq were used for mechanistic investigations.ResultsPatients with iCCA who were administered ARBs had a better prognosis and a lower proportion of tumour stroma, indicating alleviated fibrosis. The presence of AGTR1, the ARBs receptor, is associated with a poor prognosis of iCCA and is highly expressed in tumour tissues and cancer‐associated fibroblasts (CAFs). The ARBs strongly attenuated the viability of AGTR1+CAFs in vitro and retarded tumour progression and fibrosis in xenograft models of co‐cultured CAFs and iCCA cells. Still, they did not have a significant effect on AGTR1−CAFs. Moreover, ARBs decreased the secretion of AGTR1+CAF‐derived MFAP5 via the Hippo pathway, weakened the interaction between CAFs and iCCA cells, and impaired the aggressiveness of iCCA cells by attenuating the activation of the Notch1 pathway in iCCA cells.ConclusionsARBs exhibit anti‐fibrotic function by inhibiting the viability of AGTR1+CAFs. These findings support using ARBs as a novel therapeutic option for targeting iCCA.
DC: 0–5 system in clinical assessment with specialty pediatric populations
Authors: Dahl Claire M. , Bauer Maya J. , Kroupina Maria 
Published: March 2023

AbstractEarly childhood mental health (ECMH) programs provide an opportunity to provide specialized mental health services to vulnerable young children and connect them with necessary evidence‐based early intervention. However, there is a paucity of descriptive and explorative studies of the clinic protocols in the literature. Even within published work, there is a lack of standardization in clinical models and diagnostic systems limiting comparison and extrapolation. This paper describes how the DC: 0–5 framework guides the development of the model for an ECMH clinic embedded in the context of academic pediatrics. It also highlights the opportunity the DC 0–5 presents for developing the standardized protocols and a mechanism for standardized data collection in clinical settings. The paper demonstrates the utility of using the DC 0–5 in protocol development, assessment and data collection the mental health assessments of 87 children ages 0–6 were reviewed to gather information on history, presenting problems, parent‐child relationship, and mental health diagnoses. This paper and associated data underscore the utility and necessity of ECMH clinics while identifying challenges in the field.