bluuebunny/crossref_metadata_2025_split huggingface dataset:
4D Printing of Polyvinyl Chloride (PVC): A Detailed Analysis of Microstructure, Programming, and Shape Memory Performance
Authors: Aberoumand Mohammad , Soltanmohammadi Kianoosh , Rahmatabadi Davood , Soleyman Elyas , Ghasemi Ismaeil , Baniassadi Majid , Abrinia Karen , Bodaghi Mahdi , Baghani Mostafa 
Published: February 2023

AbstractIn this research, polyvinyl chloride (PVC) with excellent shape‐memory effects is 4D printed via fused deposition modeling (FDM) technology. An experimental procedure for successful 3D printing of lab‐made filament from PVC granules is introduced. Macro‐ and microstructural features of 3D printed PVC are investigated by means of wide‐angle X‐ray scattering (WAXS), differential scanning calorimetry (DSC), and dynamic mechanical thermal analysis (DMTA) techniques. A promising shape‐memory feature of PVC is hypothesized from the presence of small close imperfect thermodynamically stable crystallites as physical crosslinks, which are further reinforced by mesomorphs and possibly molecular entanglement. A detailed analysis of shape fixity and shape recovery performance of 3D printed PVC is carried out considering three programming scenarios of cold (Tg −45 °C), warm (Tg −15 °C), and hot (Tg +15 °C) and two load holding times of 0 s, and 600 s under three‐point bending and compression modes. Extensive insightful discussions are presented, and in conclusion, shape‐memory effects are promising,ranging from 83.24% to 100%. Due to the absence of similar results in the specialized literature, this paper is likely to fill a gap in the state‐of‐the‐art shape‐memory materials library for 4D printing, and provide pertinent results that are instrumental in the 3D printing of shape‐memory PVC‐based structures.
Facile Synthesis of Fe3O4−SiO2Nanocomposites for Wastewater Treatment
Authors: Yaseen Muhammad , Khan Abbas , Humayun Muhammad , Farooq Saima , Shah Nasrullah , Bibi Shaista , Khattak Zafar A. K. , Rehman Ata Ur , Ahmad Sajjad , Ahmad Shah Masood , Bououdina Mohamed , Ullah Habib 
Published: February 2023

AbstractWater constitutes ≈70–90% of the organism's body by mass and is highly important for its survival. Water contains a variety of chemical contaminants introduced by various sectors, resulting in contamination that has a direct impact on the ecosystem. Various approaches are in practice to tackle these issues. Among these, semiconductor photocatalysis appears to be the cutting‐edge technology for the degradation of wastewater contaminants. Herein, the fabrication of Fe3O4−SiO2nanocomposite via facile co‐precipitation and Stober methods are reported. Various characterization techniques are employed for the structural elucidation, morphology, crystallinity, and stability of the as‐prepared composite. The nanocomposite is employed in catalytic and photocatalytic applications toward the removal of methylene blue (MB) and methyl orange (MO) dyes from a comparative perspective. It is observed that the composite can remove about 93% of MB and 51% of MO within 7 and 6 h, respectively. These findings indicate that the nanocomposite has a higher MB removal effectiveness than the MO. This trend can be accredited to the difference in the chemical structure of both dyes. The nanocomposite is also evaluated for antioxidant and antileishmanial activity, and it is shown to be quite effective even at very low concentrations.
Hallmarks and potential pitfalls of customer‐ and consumer engagement scales: A systematic review
Authors: Hollebeek Linda D. , Sarstedt Marko , Menidjel Choukri , Sprott David E. , Urbonavicius Sigitas 
Published: February 2023

AbstractMultiple scales measuring a customer's, or consumer's, engagement (CE) with a brand or specific brand elements (e.g., advertising/social media content) have been proposed in the literature, offering researchers different options to gauge CE. However, the myriad proposed operationalizations can yield confusion among scholars regarding how to best capture CE, exposing a growing issue for CE research. Addressing this issue, we take stock of major scales measuring a CE with a brand or specific brand elements. To achieve this objective, we performed a systematic review of major CE scale development articles (2005 to January 2023) using the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) approach. We systematically evaluated these scales in terms of their respective CE conceptualization, dimensionality, itemization, and underlying theoretical perspective. We also identify potential scale‐related risks, or pitfalls, exposing important insight for CE researchers. Overall, the results suggest the existence of theoretical contamination in specific CE measures (e.g., through the inclusion of related concepts in the proposed CE definition), compromising their theoretical rigor and raising a need for scholars to verify the theoretical underpinnings of their adopted CE scales.
It's not mine: Anthropomorphism attenuates the effect of psychological ownership on product‐to‐self judgment
Authors: Zhang Ziqi , Zhou Qiang (Kris) , Yan Dengfeng 
Published: February 2023

AbstractPrevious literature has shown that consumers often see themselves as possessing the characteristics of products they own, referring to product‐to‐self judgment effect. For example, consumers perceive themselves as more innovative after owning an innovative product. The current research identifies and demonstrates a boundary condition for this effect, showing that product anthropomorphism lowers the tendency for consumers to judge themselves in assimilation with the traits and abilities of the product. We further demonstrate that this moderating effect arises because consumers are less likely to classify anthropomorphized product into the “Self” category, for they see the product as an entity like other people. Three experiments provide supportive evidence for this moderating effect and the underlying mechanism. Overall, our research contributes to the literature by uncovering the process of how product anthropomorphism may hinder consumers from using products to express themselves, thus providing implications for promoting products that focus on enhancing consumer self‐expression.
Have We Forgotten What Tics Are? A Re‐Exploration of Tic Phenomenology in Youth with Primary Tics
Authors: Nilles Christelle , Martino Davide , Fletcher Julian , Pringsheim Tamara 
Published: February 2023

ABSTRACTBackgroundThe first systematic description of tics in a large sample was in 1978.ObjectivesTo assess the phenomenology of tics in youth and investigate how age and sex influence tic phenomenology.MethodsChildren and adolescents with primary tic disorders have been prospectively included in our Registry in Calgary, Canada, since 2017. We examined tic frequency and distribution using the Yale Global Tic Severity Scale, differences between sexes, and changes in tic severity with age and with mental health comorbidities.ResultsA total of 203 children and adolescents with primary tic disorders were included (76.4% males; mean age = 10.7 years, 95% CI = 10.3–11.1). At first assessment, the most common simple motor tics were eye blinking (57%), head jerks/movements (51%), eye movements (48%) and mouth movements (46%); 86% had at least one simple facial tic. The most frequent complex motor tics were tic‐related compulsive behaviors (19%). Throat clearing was the most common simple phonic tic (42%); 5% only had coprolalia. Females had higher frequency and intensity of motor tics than males (P = 0.032 and P = 0.006, respectively), associated with greater tic‐related impairment (P = 0.045). Age was positively correlated with the Total Tic Severity Score (coefficient 0.54, P = 0.005), along with the number, frequency and intensity of motor tics but not with their complexity. Psychiatric comorbidities were associated with greater tic severity.ConclusionsOur study suggests that age and sex affect clinical presentation in youth with tics. The phenomenology of tics in our sample was similar to the 1978 description of tics, and contrasts with functional tic‐like behaviors.
Impact of sex and aging on radiographic and functional parameters of the anal sphincter complex in patients with accidental bowel leakage
Authors: Artsen Amanda M. , Dyer Keisha Y. , Routzong Megan R. , Zazueta‐Damian Gisselle , Weinstein Milena M. , Alperin Marianna 
Published: February 2023

AbstractAimsTreatment outcomes for accidental bowel leakage (ABL) may be influenced by age‐related sarcopenia. We sought to determine if thickness of the anal sphincter complex on endoanal ultrasound correlated with function in women and men with ABL and if women demonstrated age‐related anal sphincter thinning.MethodsConsecutive patients with ABL presenting to our pelvic floor clinic from 2012 to 2017 were included. Clinical data were obtained from medical records. External anal sphincter (EAS), imaged by endoanal ultrasound at proximal, mid and distal locations, and IAS thickness were measured at 12, 3, 6, and 9 o'clock; puborectalis muscle (PRM) was measured at 4, 6, and 8 o'clock; and averaged. Anorectal manometry was conducted when clinically indicated. Data were compared using Mann–Whitney tests and linear regression. Results are reported as mean ± SD or median (IQR).ResultsWomen (n = 136) were younger than men (n = 26) (61 ± 13 vs. 67 ± 13 years, p = 0.02). More women than men had pelvic surgery and less had colorectal surgery, spinal disorders, or a history of smoking (p < 0.05). Eighty‐two percentage of women had an anal sphincter defect versus 31% of men (p < 0.01). All anal sphincter complex components were thinner in women than men with lower squeeze and resting pressures (p < 0.03), even in nulliparous women. Mean resting pressure was lower in older 6.1 (4.6–7.8) versus younger women 8.3 (5.0–12.9) mmHg, p = 0.04.ConclusionsWomen, even nulliparous, with ABL demonstrate thinner and weaker anal sphincters than men, Aging correlated with an increase in anal sphincter thickness, suggesting that age‐related changes in the intrinsic components of the anal sphincter complex associated with ABL are complex and are not always well demonstrated on endoanal ultrasound.
Effects of acupuncture on obstructive sleep apnea–hypopnea syndrome: A meta‐analysis
Authors: Lin Jiamin , Kong Yue , Chen Hailan , Zhu Meilin , Lv Qian , Xu Baoling , Zhu Fangfang 
Published: February 2023

AbstractOur study aimed to systematically evaluate the effect of acupuncture in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). Literature search of four Chinese databases and six English databases for studies published from the inception of each database to March 1, 2022 and identify relevant studies published in Chinese or English. Related randomized controlled trials of acupuncture for the treatment of OSAHS were included to analyze the efficacy of acupuncture. Two researchers independently reviewed all of the retrieved studies to screen for eligible studies and extract the required relevant data. Included studies were subjected to a methodological quality assessment using the Cochrane Manual 5.1.0, and to a meta‐analysis using Cochrane Review Manager version 5.4. A total of 19 studies with 1365 participants were examined. Compared with the control group, the apnea–hypopnea index, lowest oxygen saturation, Epworth Sleepiness Scale, interleukin‐6, tumor necrosis factor α, and nuclear factor κ‐B indicators all exhibited statistically significant changes. Thus, acupuncture was effective in alleviating the state of hypoxia and sleepiness and reduced the inflammatory response and disease severity among reported patients with OSAHS. Therefore, acupuncture could be widely used in the clinical treatment of OSAHS patients as a complementary strategy and warrants further study.
Fabrication and characterization of polylactic acid/natural fiber extruded composites
Authors: Alothman Othman Y. , Awad Sameer , Siakeng Ramengmawii , Khalaf Eman M. , Fouad Hassan , Abd El‐salam Nasser M. , Ahmed Faraz , Jawaid M. 
Published: February 2023

AbstractIn this work, the fabricated polylactic acid (PLA) and hybrid natural fiber (NF) biocomposites via a melt extrusion method were investigated. NFs from locally grown plants were utilized as fillers. Polyethene glycol (PEG) was used as the plasticizer to improve the processability of the PLA. The effect of PLA/NF biocomposite processing was assessed by mechanical characterization (tensile, modulus, strain at break, and impact tests), and thermal properties (thermogravimetric analysis and differential scanning calorimetry [DSC] analysis). The dynamic mechanical analysis (DMA), and thermo‐mechanical analysis (TMA) of the samples were also analyzed. The mechanical properties of PLA/NF biocomposites improved as compared with that of PLA. The DMA findings show that the storage modulus and loss modulus exhibited a slight reduction for PLA/NF biocomposites compared with the PLA sample. In opposite, the glass transition temperature (Tg) from DSC thermogram results showed no obvious changes in values compared with the PLA sample. Furthermore, the findings of TMA showed a significant decrease in coefficient of thermal expansion values of PLA/NF biocomposites compared with those of PLA samples. The overall findings from this work indicated that PLA/NF biocomposites have the potential to make novel biocomposites and suitable for further application especially in biomedical applications due to its good stiffness, tensile strength, and dimensional stability.
Integrated tandem affinity protein purification using the polyhistidine plus extra 4 amino acids (HiP4) tag system
Authors: Ino Yoko , Yamaoka Yutaro , Tanaka Kiho , Miyakawa Kei , Nishi Mayuko , Hatayama Yasuyoshi , Kimura Hirokazu , Kimura Yayoi , Ryo Akihide 
Published: February 2023

AbstractPeptide tag systems are a robust biophysical and biochemical method that is widely used for protein detection and purification. Here, we developed a novel tag system termed “HiP4” (histidine plus four amino acids) whose epitope sequence comprises only seven amino acids (HHHDYDI) that partially overlap with the conventional 6x histidine tag (6xHis‐tag). We produced a monoclonal antibody against the HiP4 tag that can be used in multiple immunoassays with high specificity and affinity. Using this system, we developed a tandem affinity purification (TAP) and mass spectrometry (TAP‐MS) system for comprehensive protein interactome analysis. The integrated use of nickel bead purification followed by HiP4 tag immunoprecipitation made it possible to reduce nonspecific binding and improve selectivity, leading to the recovery of previously unrecognized proteins that interact with hepatitis B virus X (HBx) protein or TAR DNA‐binding protein 43 (TARDBP or TDP‐43). Our results indicate that this system may be viable as a simple and powerful tool for TAP‐MS that can achieve low background and high selectivity in comprehensive protein–protein interaction analyses.
Impact of elexacaftor/tezacaftor/ivacaftor on bacterial cultures from people with cystic fibrosis
Authors: Beck Michael R. , Hornick Douglas B. , Pena Tahuanty A. , Singh Sachinkumar B. , Wright Brittany A. 
Published: February 2023

AbstractBackgroundCystic fibrosis transmembrane conductance regulator (CFTR) modulators have shown beneficial effects on both forced expiratory volume in 1 s (FEV1) and frequency of pulmonary exacerbations in people with cystic fibrosis (CF). These positive outcomes may be related to changes in bacterial colonization within the lungs. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is the first triple therapy CFTR modulator approved for use in people with CF 6 years and older. This study aimed to determine the impact of ELX/TEZ/IVA on the isolation of Pseudomonas aeruginosa (Pa), methicillin‐resistant and methicillin‐susceptible Staphylococcus aureus (MRSA and MSSA, respectively) in respiratory cultures.MethodsA retrospective chart review of the electronic medical record at the University of Iowa was completed for individuals 12 years and older taking ELX/TEZ/IVA for at least 12 months. The primary outcome was determined by assessing bacterial cultures pre‐ and postinitiation of ELX/TEZ/IVA. Baseline demographic and clinical characteristics were summarized using mean and standard deviation for continuous outcomes and count and percentage for categorical outcomes. Culture positivity for Pa, MSSA, and MRSA was compared among enrolled subjects between pre‐ and posttriple combination therapy periods using an exact McNemar's test.ResultsOne hundred and twenty‐four subjects prescribed ELX/TEZ/IVA for at least 12 months met the requirements for inclusion within our analysis. Culture positivity for Pa, MSSA, and MRSA was approximately 54%, 33%, and 31%, respectively, for the pre‐ELX/TEZ/IVA period. Prevalence decreased to approximately 30%, 32%, and 24% (−24.2% [p < 0.0001], −0.7% [p = 1.00], and −6.5% [p = 0.0963], respectively) post‐ELX/TEZ/IVA. The source of bacterial culture was predominantly sputum (70.2%) in the pre‐ELX/TEZ/IVA group, whereas a throat source (66.1%) was more common post‐ELX/TEZ/IVA.ConclusionsELX/TEZ/IVA treatment has an appreciable impact on the detection of common bacterial pathogens in CF respiratory cultures. While previous studies have found a similar effect with single and double CFTR modulator therapies, this is the first single‐center study to show the impact of triple therapy, ELX/TEZ/IVA, on bacterial isolation from airway secretions.
Defined daily doses in pediatric dosing‐ a theoretical example
Authors: Dahlén Elin , Kindblom Jenny Marianne , Kimland Elin Eyfells 
Published: February 2023

AbstractA defined daily dose for children (cDDD) taking body weight into account, was proposed as a better measure of drug utilization in children than the World Health Organization's DDD. There is no global definition of DDDs for children, and it is unclear which standard doses should be used for children when conducting drug utilization studies. We used doses according to the authorized medical product information and body weight according to national pediatric growth curves to calculate theoretical cDDD for three common medicines in children in a Swedish setting. These examples demonstrate that the concept of cDDD may not be optimal for drug utilization studies in children, especially not for younger children and when dosing is done according to weight is crucial. Validation of cDDD in real‐world data is warranted. When conducting pediatric drug utilization studies, accessibility to individual‐level data on body weight and age combined with dosing information is needed.
The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella(L.)
Authors: Li Yifan , Ni Shujun , Wang Yunping , Li Ruichi , Sun Hong , Ye Xuan , Tian Zhen , Zhang Yalin , Liu Jiyuan 
Published: February 2023

AbstractBACKGROUNDInsecticide resistance continuously poses a threat to agricultural production. Chemosensory protein‐mediated resistance is a new mechanism of insecticide resistance discovered in recent years. In‐depth research on resistance mediated by chemosensory proteins (CSPs) provides new insight into aid insecticide resistance management.RESULTSChemosensory protein 1 in Plutella xylostella (PxCSP1) was overexpressed in the two indoxacarb‐resistant field populations and PxCSP1 has a high affinity with indoxacarb. PxCSP1 was upregulated when exposed to indoxacarb and the knockdown of this gene elevated sensitivity to indoxacarb, which demonstrate that PxCSP1 is involved in the indoxacarb resistance. Considering that CSPs may confer resistance in insects via binding or sequestering, we explored the binding mechanism of indoxacarb in PxCSP1‐mediated resistance. Using molecular dynamics simulations and site‐directed mutation, we found that indoxacarb forms a solid complex with PxCSP1 mainly through van der Waals interactions and electrostatic interactions. Between these, the electrostatic interaction provided by the Lys100 side chain in PxCSP1, and especially the hydrogen bonding between the NZ atom and the O of the carbamoyl carbonyl group of indoxacarb, are the key factors for the high affinity of PxCSP1 to indoxacarb.CONCLUSIONSThe overexpression of PxCPS1 and its high affinity to indoxacarb is partially responsible for indoxacarb resistance in P. xylostella. Modification of indoxacarb's carbamoyl group has the potential to alleviate indoxacarb resistance in P. xylostella. These findings will contribute to solving chemosensory protein‐mediated indoxacarb resistance and provide a better understanding of the insecticide resistance mechanism. © 2023 Society of Chemical Industry.
Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model
Authors: Timalsina Binod , Haque Md Nazmul , Choi Ho Jin , Dash Raju , Moon Il Soo 
Published: February 2023

AbstractSeveral reports have stated the neuroprotective and learning/memory effects ofTachyspermum ammiseed extract (TASE) and its principal component thymol; however, little is known about its underlying molecular mechanisms and neurogenesis potential. This study aimed to provide insights into TASE and a thymol‐mediated multifactorial therapeutic approach in a scopolamine‐induced Alzheimer's disease (AD) mouse model. TASE and thymol supplementation significantly reduced oxidative stress markers such as brain glutathione, hydrogen peroxide, and malondialdehyde in mouse whole brain homogenates. Tumor necrosis factor‐alpha was significantly downregulated, whereas the elevation of brain‐derived neurotrophic factor and phospho‐glycogen synthase kinase‐3 beta (serine 9) enhanced learning and memory in the TASE‐ and thymol‐treated groups. A significant reduction in the accumulation of Aβ 1–42 peptides was observed in the brains of TASE‐ and thymol‐treated mice. Furthermore, TASE and thymol significantly promoted adult neurogenesis, with increased doublecortin positive neurons in the subgranular and polymorphic zones of the dentate gyrus in treated‐mice. Collectively, TASE and thymol could potentially act as natural therapeutic agents for the treatment of neurodegenerative disorders, such as AD.