bluuebunny/crossref_metadata_2025_split huggingface dataset:
A potential novel biomarker: Comprehensive analysis of prognostic value and immune implication of CES3 in colonic adenocarcinoma
Authors: He Lulu , Zhao Chenyi , Xu Jingjing , Li Wenjing , Lu Yujie , Gong Yang , Gu Dingyi , Wang Xiaoyan , Guo Feng 
Published: June 2023

Abstract
Purpose: Colon cancer is the most common malignant tumor in the intestine. Abnormal Carboxylesterases 3 (CES3）expression had been reported to be correlated to multiple tumor progression. However, the association among CES3 expression and prognostic value and immune effects in colonic adenocarcinoma (COAD) were unclear.
Patients and methods: The transcription profile of CES3 were downloaded from The Cancer Genome Atlas (TCGA). The CES3 protein expression and the prognostic value were verified based on tissue microarray data. The Cancer immune group Atlas (TCIA), Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and the GSE78220 immunotherapy cohort were used to forecast immunotherapy efficacy. Finally, a prognostic immune signature was constructed and verified.
Results: Compared with normal colon tissues, the expression of mRNA and protein levels of CES3 were downregulated in tumor tissues. CES3 expression was associated with TIICs. Hihg-CES3 COAD patients had better efficacy of concurrent immunotherapy. CES3-related immune genes (CRIs) were identified and were then used to construct prognostic immune signature and had been successfully verified in GES39582.
Conclusion: CES3 might be a potential immune-related gene and promising prognostic biomarker in COAD.
Simulation Method of Outdoor AGV Obstacle Crossing without 3D Model
Authors: yingbo Zhao , Xiu Shi-chao , Hong Yuan , Bu Xinyu 
Published: June 2023

Abstract
In this study, an outdoor Automated guided vehicle (AGV) with an absorbent vibration system was designed, and a 7-DOF model was established for this system. We built a simulation model in Simulink software that serves as the 7-DOF model. The three indicators for evaluating the stability of the AGV are simulated and analyzed in the simulation model when one side of the AGV crosses a sloping obstacle. A vibration absorptive property experiment of the AGV was performed, and the average maximum displacement of the AGV sprung mass was 13.42 mm. The maximum predicted amplitude of sprung mass in the Simulink simulation model is 12.8mm, and its prediction error is about 4.6%. The prediction accuracy of the Simulink model is higher than that of the Adams simulation method.According to the efficiency comparison experiment of the AGV obstacle crossing simulation method, the obstacle crossing simulation method based on Simulink designed in this paper saves about 28% of the working time of the designer compared with the traditional Adams simulation method, which provides a new idea for the simulation method of outdoor AGV obstacle crossing before the 3D model is established.
Therapeutic efficacy of Oral Carica papaya leaf juice extract in the supportive care of infectious thrombocytopenia in bleeding dogs.
Authors: G.R BARANIDHARAN , A.P NAMBI 
Published: June 2023

Abstract

Background: In rural India, oral Carica papaya leaf extract juice (CPLE) has been used to control bleeding and recover platelet counts in human patients with dengue fever, and few reports of successful outcomes have been published.
Hypothesis: CPLE juice oral dosing has thrombopietic properties that significantly increase platelet counts in thrombocytopenic dogs with bleeding tendencies.
Animals: Ninetythrombocytopenic dogs with ehrlichiosis, babesiosis, and/or leptospirosis referred to Madras Veterinary College Teaching Hospital were studied.
Methods:
During a one-year period, 90 thrombocytopenic dogs with ehrlichiosis, babesiosis, and/or leptospirosis with mild thrombocytopenia (platelets 50,000-100,000/µl) to severe thrombocytopenia (platelets less than 25,000µl) with bleeding were studied. ... In addition, coagulation profiles, buccal mucosal bleeding times, saline agglutination tests, spherocyte studies, direct Coombs’ (Direct Antiglobin) tests, Von Willebrand Factor assays, Platelet-associated antibody (PSAb) assays, bone marrow aspiration cytology, and DEA 1 typing were determined. Platelet-rich plasma or fresh whole blood wastransfused in casesof severe (platelets <20,000 cells/µl) thrombocytopenia and/or anemia, and all dogs received doxycycline and prednisone. CPLE was administered at 5 ml per 10 kg body weight for 3 weeks.
Results:
Dogs with Ehrlichiosis, Babesiosis and Leptospirosis with clinical bleeding signs with mild thrombocytopenia (50,000 – 100,000 platelets/cmm) responded well to oral administration of Carica papaya leaf extract 5 ml per 10 kg b.wt + doxycycline @ 10 mg/kg b.wts.i.d orally + prednisolone @ 1 mg/kg b.wt once a day tapering dose orally for 3 weeks.
Clinical trials with Caricapapaya leaf extract confirmed an increase in the platelet counts from day two, and they were on a significantly increasing trend up to day seven, proving the thrombopoietic properties of CPLE juice in dogs.
Conclusion:
CPLE may be an inexpensive supplement to more rapidly control thrombocytopenia and bleeding in dogs with hemoprotozoan diseases along with specific therapies and transfusion.
Degradation of aniline: sodium alginate/modified pomelo cellulose double cross-linking system as a bacterial immobilization carrier
Authors: Fan Zheng , Fang Zhenzhen , Tao Peng , Jin Laiyun , Zhang Guoliang 
Published: June 2023

Abstract
Pectin cellulose grafted with glycidyltrimethylammoniochloride (GTMAC) was successfully obtained following the processes of depectinfibrillation and cellulose cationization using ordinary Shatian pomelo peel produced in Yongzhou, Hunan, as the raw material. This is the first report on a new type of functionalized sodium alginate-immobilized material prepared from the fibers of pomelo peel. The material was prepared by combining modified pomelo peel cellulose and sodium alginate following the processes of physical and chemical double cross-linking. The prepared material was used to embed the target bacteria to achieve the biodegradation of p-aniline. The concentration of CaCl2 was adjusted when the alginate gelled, and the alginate to yuzu peel cellulose ratio was tuned. The immobilized material-embedded bacteria help achieve the best degradation effect. Bacteria are embedded during the process of the degradation of aniline wastewater, and the functionalization of the cellulose/sodium alginate-immobilized material results in unique surface structure performance. The performance of the prepared system is better than that of the single sodium alginate-based material characterized by a large surface area and good mechanical properties. The degradation efficiency of the system is improved significantly for the cellulose materials, and the prepared materials can potentially find applications in the field of bacteria-fixed technology.
Outcomes and Factors Affecting Transcranial Direct Current Stimulation
in Alzheimer's Disease Patients: A Systematic Review
Authors: Tariq Rabeet , Kansal Bhavya , Shaikh Rameen , Datta Shria , Anadkat Harsh , Bista Seema 
Published: June 2023

Introduction:
Alzheimer's disease (AD) is the most common form of dementia. There have
been various proposed pharmacologic and non-pharmacologic treatments proposed for preventing
cognitive decline in AD patients. Transcranial Direct Current Stimulation (tDCS) is a neuromodulation
technique used to enhance cognitive functions and motor skills of the brain. Our study aimed to
assess the effects of tDCS in AD patients, including effects on general cognitive status, memory, attention,
executive functions, language, IQ, and neuropsychological effects, along with the factors influencing
the outcomes.

Methods:
Systematic searches were conducted for relevant evidence using PubMed, ScienceDirect,
and Cochrane Library databases for (Transcranial Direct Current Stimulation) and (Alzheimer’s). Duplicates
were removed, and the remaining articles were screened for double-blind, placebo-controlled,
randomized clinical trials (Phase III), case studies, and case series on patients diagnosed with AD using
tDCS. The articles were assessed for full text, and studies were selected and analyzed to include in
the review.

Results:
Overall, 20 studies were reviewed. Cognitive status, executive function and working
memory, recognition memory, and language function may improve following AtDCS depending on
the stimulation polarity and area stimulated. No significant effects of tDCS were seen on attention,
associative memory, recall memory, visuospatial ability, and neuropsychiatric symptoms

Discussion:
Therapy outcomes and the factors that could affect them were analyzed, which included
the number of sessions taken, current density, stimulation polarity (cathodal/anodal/dual), area stimulated,
training(s) given, and study timeline.

Conclusion:
tDCS is a well-tolerated therapy that can be used for improving several cognitive domains
in patients having Alzheimer’s disease. Its treatment outcomes are affected by polarity (cathodal/
anodal), site of stimulation, number of sessions taken, and any training(s) given during the study.
Investigating Factors Affecting Preterm Delivery from the Viewpoint of
Physicians and Midwives in Mashhad
Authors: Talebizadeh Seyedeh Zeinab , Salehi Fatemeh , Setoodefar Masood , Habibi Mohammad Reza Mazaheri 
Published: June 2023

Background:
Premature delivery is a significant risk factor for mortality in both developed
and developing nations, causing long-term adverse effects on families in terms of physical, psychological,
and economic consequences.

Objective:
This research aimed to examine the elements influencing preterm delivery from the perspectives
of obstetrics, gynecology specialists, and midwives in Mashhad, Iran's metropolis.

Method:
This study was a descriptive cross-sectional study. A questionnaire was used to collect data
from 30 medical professionals working in clinics, hospitals, and health facilities in Mashhad in 2020.
In this study, 30 medical professionals participated, including 10 obstetrics and gynecology specialists
with a mean age of 50±8.0, and 20 midwives with a mean age of 34±4 years. The survey found that
premature rupture of the amniotic sac (water sac) was the most frequent factor contributing to preterm
delivery, with a frequency of 96.7%. This was followed by uterine abnormality, preeclampsia, and
chorioamnionitis, each with a frequency of 93.3%. Other factors such as a history of preterm delivery
and multiple pregnancies were also found to impact preterm delivery, with a frequency of 90%. Additionally,
the study revealed that stress factors had the highest frequency in the high-impact spectrum,
with a frequency of 86.7%.

Results:
This study is a survey of caregiver’s opinions about preterm birth from one location. The
findings revealed that the main causes of preterm delivery were premature rupture of the amniotic sac,
uterine abnormalities, preeclampsia, and chorioamnionitis.

Conclusion:
Furthermore, background factors, such as stress factors and domestic violence in mothers
can affect this phenomenon. Overall, these findings highlight the critical role of clinical and lifestyle
factors in preterm delivery.
The Implication of Alu cDNA in the Pathogenesis of ARMD
Authors: Nouraeinejad Ali 
Published: June 2023

Abstract:
Age-related macular degeneration (ARMD or AMD) is a progressive, sight-threatening
disease. The pathogenesis of ARMD is complex, involving many factors, such as metabolic, functional,
genetic, and environmental factors. Recently, long interspersed nuclear element-1 (L1)–
mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
(cDNA) has been associated with retinal pigment epithelium (RPE) destruction. These findings
provide a strong input for a new direction in the management of ARMD, as certain human immunodeficiency
virus (HIV) drugs, such as nucleoside reverse transcriptase inhibitors (NRTIs), were
found to suppress inflammation and protect cells of the retina.
Focus. Nieuwe kijk op wet en evangelie
Authors: Te Velde R.T. 
Published: June 2023

N.a.v.: Maarten Wisse, Reinventing Christian Doctrine. Retrieving the Law-Gospel Distinction (Londen e.a.p.: T&T Clark, 2023) 216 p., € 129,95 (ISBN: 978-0-5677-0430-6).
Improving the Health and Well-Being of Individuals by Addressing Social, Economic, and Health Inequities (Healthy Eating Active Living): Protocol for a Cohort Study
Authors: Joshi Ashish , Mohan Surapaneni Krishna , Pandya Apurva Kumar , Grover Ashoo , Kaur Harpreet , Gupta Mansi , Aurora Heemanshu , Bhatt Ashruti 
Published: June 2023

Background
Health inequity is interlinked with the good health and well-being of an individual. Health inequity can be due to various socioeconomic factors like income levels or social status. Digital health interventions have the potential to reduce the existing health inequities.

Objective
This study aims to identify determinants of social, economic, and health inequity in diverse settings to enhance healthy eating and active living. It further aims to design and develop a digital health intervention HEAL (Healthy Eating Active Living) that incorporates a human-centered design framework in order to improve healthy eating and active living among rural and urban population groups in Chennai, Tamil Nadu, India.

Methods
A prospective, 3-year cohort study will be conducted. This study aims to recruit 6350 individuals across rural and urban settings of Chennai. A total of 11 sites have been selected for participation in the study. Data on sociodemographic characteristics; economic inequity; HEAL profile; depression, anxiety, and stress; well-being; sources of health information; perceived access to health care; health literacy; navigation of health literacy; and satisfaction with the health system will be gathered. This study would help to explore the determinants of social, economic, and health inequity across multiple sites. SAS (version 9.3; SAS Institute Inc) will be used for data analysis, and results will be reported as 95% CI and P values. This study’s findings will guide the design and development of a tailored, human-centered digital health intervention to enhance the health and well-being of Chennai’s population groups.

Results
As of December 2024, the literature review for the development of the intervention has been completed. The recruitment for the baseline data collection will begin shortly, followed by the development of HEAL intervention.

Conclusions
The proposed study will help in examining the role of the proposed HEAL intervention to enhance the health and well-being of the population groups of Chennai.

International Registered Report Identifier (IRRID)
PRR1-10.2196/41169
Effectiveness of Digital Health Interventions Containing Game Components for the Self-management of Type 2 Diabetes: Systematic Review
Authors: Ossenbrink Linda , Haase Tina , Timpel Patrick , Schoffer Olaf , Scheibe Madlen , Schmitt Jochen , Deckert Stefanie , Harst Lorenz 
Published: June 2023

Background
Games and game components have become a major trend in the realm of digital health research and practice as they are assumed to foster behavior change and thereby improve patient-reported and clinical outcomes for patients with type 2 diabetes.

Objective
The aim of this systematic review was to summarize and evaluate the current evidence on the effectiveness of digital health interventions containing game components on behavioral, patient-reported, and clinical outcomes for patients with type 2 diabetes.

Methods
An electronic search was conducted in MEDLINE and PsycINFO in April 2020; updated in April 2022; and supplemented by additional searches via Google Scholar, Web of Science (which was used for forward citation tracking), and within the references of the included records. Articles were identified using predefined inclusion and exclusion criteria. In total, 2 reviewers independently conducted title, abstract, and full-text screening and then individually performed a critical appraisal of all the included studies using the Cochrane risk-of-bias tool version 2. A consensus was reached through discussion.

Results
Of 2325 potentially relevant titles (duplicates excluded), 10 (0.43%) randomized controlled trials were included in this review. Quality assessment revealed a high risk of bias for all randomized controlled trials except for 10% (1/10), with performance bias due to the lack of blinding being the major source of bias. There is evidence suggesting that digital health interventions containing game components can substantially improve motivation for physical activity (1/1, 100% of the studies dealing with PA motivation), exercise intensity (3/5, 60%), dietary behavior (4/4, 100%), health literacy (1/3, 33%), mental quality of life (2/2, 100%), glycated hemoglobin level (2/6, 33%), BMI (1/3, 33%), fasting plasma glucose level (1/2, 50%), waist circumference (1/1, 100%), and aerobic capacity (1/1, 100%).

Conclusions
Published studies indicated that digital health interventions containing game components might improve health behavior patterns, quality of life, and clinical outcomes in patients with type 2 diabetes. However, the intervention types and outcomes studied were heterogeneous, and study quality was mostly low, which translates to ambiguous results. Future research should focus on sound methodology and reporting as well as on identifying game components that contribute to significant positive effects.

Trial Registration
PROSPERO CRD42020209706; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=209706
Supporting Adolescents With HIV in South Africa Through an Adherence-Supporting App: Mixed Methods Beta-Testing Study (Preprint)
Authors: Mulawa Marta I , Mtukushe Bulelwa , Knippler Elizabeth T , Matiwane Mluleki , Al-Mujtaba Maryam , Muessig Kathryn E , Hoare Jacqueline , Hightow-Weidman Lisa B 
Published: June 2023

BACKGROUND

Novel smartphone app–delivered interventions have the potential to improve HIV treatment adherence among adolescents with HIV, although such interventions are limited. Our team has developed <i>Masakhane Siphucule Impilo Yethu</i> (MASI; Xhosa for “Let's empower each other and improve our health”), a smartphone app–delivered intervention to improve treatment adherence among adolescents with HIV in South Africa. MASI was adapted to the South African cultural context using the HealthMpowerment platform, an evidence-based digital health intervention developed for and with youth in the United States.

OBJECTIVE

We conducted this beta-testing study to (1) explore the initial usability of MASI, (2) examine engagement and experiences using MASI features, and (3) inform refinements to the app and intervention implementation plan prior to a subsequent pilot randomized controlled trial (RCT).

METHODS

This study was conducted from August 2021 to December 2021 in Cape Town, South Africa. Beta-testing participants received access to MASI for 3 weeks. A mixed methods approach was used, with brief questionnaires and semistructured in-depth interviews conducted prior to app installation and after 1 week to 2 weeks of app testing. Engagement with MASI was measured through analysis of back-end app paradata, and follow-up in-depth interview guides were tailored to each participant based on their app use.

RESULTS

Participants in the beta-testing study (6 male participants, 6 female participants; ages 16-19 years) collectively spent 4.3 hours in MASI, averaging 21.4 minutes per participant over the 3-week period (range 1-51.8 minutes). Participants logged into MASI an average of 24.1 (range 10-75) times during the study period. The mean System Usability Scale score was 69.5 (SD 18), which is considered slightly above average for digital health apps. Thematic analysis of qualitative results revealed generally positive experiences across MASI features, although opportunities to refine the app and intervention delivery were identified.

CONCLUSIONS

Initial usability of MASI was high, and participants described having a generally positive experience across MASI features. Systematically analyzing paradata and using the interview findings to explore participant experiences allowed us to gain richer insights into patterns of participant engagement, enabling our team to further enhance MASI. The results from this study led to a few technological refinements to improve the user experience. Enhancements were also made to the intervention implementation plan in preparation for a pilot RCT. Lessons learned from the conduct of this beta-testing study may inform the development, implementation, and evaluation of similar app-delivered interventions in the future.
Formulation Perspectives in Topical Antifungal Drug Therapy: A Review
Authors: Godge Ganesh Raosaheb , Bharat S. C. , Shaikh A. B. , Randhawan B. B. , Raskar M. A. , Hiremath S. N. 
Published: June 2023

Topical medication delivery is the process of directly treating a cutaneous ailment or the cutaneous manifestation of a general disease by applying a pharmaceutical dosage form to the skin with the goal of reducing the drug's pharmacological or other effects to the surface of skin. A wide range of pharmacological dosage forms, such as semisolids, liquid preparations, sprays, solid powders, gels, creams, and ointments, are used in topical drug delivery systems. A gel is a cross-linked polymer network swollen in a liquid medium. Its properties depend strongly on the interaction between solid state polymer and the liquid component. Gels don't have a flow that is steady. An interlacing three-dimensional network of dispersed phase particles is created by the interaction of the polymer and the liquid dispersion medium. Because topical gel formulations are less oily and readily removed from the skin, they provide an effective medication delivery mechanism. Compared to cream and ointments, gel composition offers greater application properties and stability. One of the most frequent issues with dermatological problems is fungal infection of the skin. The most effective option for treating cutaneous infections is topical treatment. The most popular antifungals in the treatment of both local and systemic fungal infections are azoles. The benefits of topical treatment for fungal infections include less risk of systemic adverse effects and medications that are targeted to the infection site. Important actions for boosting treatment effectiveness include formulation design and optimization. The most helpful aspects of a topical medication delivery system are the medication's physiochemical characteristics and formulation type. As a result, some recent developments in formulation have been researched for the delivery of antifungal medications via the target region of the skin. This review focuses on the research that has been done so far on antifungal gel and a thorough analysis of it.
Keywords: Topical gel, Antifungal, Drug delivery, dispersion medium, fungal infection, adverse effects
A produção do espaço urbano em Frecheirinha-CE: O polo produtor de peças íntimas no Sertão Cearense
Authors: Vasconcelos Milvane 
Published: June 2023

O artigo analisa o processo de produção do espaço urbano em Frecheirinha-CE, bem como os processos que auxiliam para a construção das materialidades espaciais pelo circuito espacial da produção têxtil no seguimento de peças íntimas, papel no processo de reestruturação produtiva; identificar os agentes envolvidos, analisando as articulações empreendidas entre eles nos círculos de cooperação do espaço; culminando com a organização o território em questão. Para compreender melhor o paradigma atual da produção têxtil e de peças íntimas precisamos desvincular nossos olhares aos moldes da produção tradicional. Localizada na região Noroeste do Estado do Ceará, cidade pequena de aproximadamente 13 mil habitantes, abriga mais de 30 fábricas de peças íntimas, além de uma comércio depende dessa atividade.