bluuebunny/crossref_metadata_2025_split huggingface dataset:
PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer
Authors: Ye Huili , Shi Wengui , Yang Jing , Wang Long , Jiang Xiangyan , Zhao Huiming , Qin Long , Qin Junjie , Li Lianshun , Cai Weiwen , Guan Junhong , Yang Hanteng , Zhou Huinian , Yu Zeyuan , Sun Hui , Jiao Zuoyi 
Published: August 2023

Abstract

The chemotherapeutic agent 5-fluorouracil (5-FU) remains the backbone of postoperative adjuvant treatment for gastric cancer. However, fewer than half of patients with gastric cancer benefit from 5-FU–based chemotherapies owing to chemoresistance and limited clinical biomarkers. Here, we identified the SNF2 protein Polo-like kinase 1-interacting checkpoint helicase (PICH) as a predictor of 5-FU chemosensitivity and characterized a transcriptional function of PICH distinct from its role in chromosome separation. PICH formed a transcriptional complex with RNA polymerase II (Pol II) and ATF4 at the CCNA1 promoter in an ATPase-dependent manner. Binding of the PICH complex promoted cyclin A1 transcription and accelerated S-phase progression. Overexpressed PICH impaired 5-FU chemosensitivity in human organoids and patient-derived xenografts. Furthermore, elevated PICH expression was negatively correlated with survival in postoperative patients receiving 5-FU chemotherapy. Together, these findings reveal an ATPase-dependent transcriptional function of PICH that promotes cyclin A1 transcription to drive 5-FU chemoresistance, providing a potential predictive biomarker of 5-FU chemosensitivity for postoperative patients with gastric cancer and prompting further investigation into the transcriptional activity of PICH.

Significance:
PICH binds Pol II and ATF4 in an ATPase-dependent manner to form a transcriptional complex that promotes cyclin A1 expression, accelerates S-phase progression, and impairs 5-FU chemosensitivity in gastric cancer.
Movilidades y experiencia escolar en la periferia urbana de Córdoba, Argentina
Authors: García-Bastán Guido 
Published: August 2023

(analítico)Se analizan las intersecciones entre territorio, movilidades y experiencias educativas de jóvenes de un barrio periférico de la ciudad de Córdoba, Argentina. A partir de un abordaje etnográfico, basado en observaciones, talleres de mapeo territorial y entrevistas grupales con estudiantes de nivel secundario, damos cuenta de una monopolización de tiempos y espacios por parte de la escuela, que inhibe su participación en otras esferas sociales significativas. Desde la perspectiva juvenil, la escuela asume una connotación paradojal: es un «buen lugar» para estar, aunque también un ámbito que no satisface demandas específicas relativas a la salud, el respeto a la diversidad y el reconocimiento. El papel de las/os educadoras/es no es impugnado, tanto como el modo en que muchas/os están pudiendo hacer frente a dichas demandas.
Palabras clave: Joven; escuela secundaria; comunidad; investigación participativa.
Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome
Authors: Stifel Ulrich , Vogel Frederick , Caratti Giorgio , Reincke Martin , Tuckermann Jan 
Published: August 2023

BACKGROUND:
Cushing syndrome (CS) is a rare disease caused by excess cortisol levels with high cardiovascular morbidity and mortality. Hypertension in CS promotes hypercortisolism-associated cardiovascular events. Adipose tissue is a highly plastic tissue with most cell types strongly affected by the excess cortisol exposure. We hypothesized that the molecular and cellular changes of periadrenal adipose tissue in response to cortisol excess impact systemic blood pressure levels in patients with CS.

METHODS:
We investigated gene expression signatures in periadrenal adipose tissue from patients with adrenal CS collected during adrenal surgery.

RESULTS:
During active CS we observed a downregulation of gene programs associated with inflammation in periadrenal adipose tissue. In addition, we observed a clustering of the patients based on tissue gene expression profiles into 2 groups that differed in blood pressure levels (CS low blood pressure and CS high blood pressure). The 2 clusters showed significant differences in gene expression pattens of the renin-angiotensin-aldosterone-system. Renin was the strongest regulated gene compared with control patients and its expression correlated with increased blood pressure observed in our patients with CS. In the CS high blood pressure group, systemic renin plasma levels were suppressed indicative of an abnormal blood pressure associated with periadrenal adipose tissue renin-angiotensin-aldosterone-system activation.

CONCLUSIONS:
Here, we show for the first time a relevant association of the local renin-angiotensin-aldosterone-system and systemic blood pressure levels in patients with CS. Patients from the CS high blood pressure group still had increased blood pressure levels after 6 months in remission, highlighting the importance of local tissue effects on long-term systemic effects observed in CS.
Differential Treatment and Outcomes for Patients With Heart Attacks in Advantaged and Disadvantaged Communities
Authors: Shen Yu‐Chu , Sarkar Nandita , Hsia Renee Y. 
Published: August 2023

Background
Racially and ethnically minoritized groups, people with lower income, and rural communities have worse access to percutaneous coronary intervention (PCI) than their counterparts, but PCI hospitals have preferentially opened in wealthier areas. Our study analyzed disparities in PCI access, treatment, and outcomes for patients with acute myocardial infarction based on the census‐derived Area Deprivation Index.

Methods and Results
We obtained patient‐level data on 629 419 patients with acute myocardial infarction in California between January 1, 2006 and December 31, 2020. We linked patient data with population characteristics and geographic coordinates, and categorized communities into 5 groups based on the share of the population in low or high Area Deprivation Index neighborhoods to identify differences in PCI access, treatment, and outcomes based on community status. Risk‐adjusted models showed that patients in the most advantaged communities had 20% and 15% greater likelihoods of receiving same‐day PCI and PCI during the hospitalization, respectively, compared with patients in the most disadvantaged communities. Patients in the most advantaged communities also had 19% and 16% lower 30‐day and 1‐year mortality rates, respectively, compared with the most disadvantaged, and a 15% lower 30‐day readmission rate. No statistically significant differences in admission to a PCI hospital were observed between communities.

Conclusions
Patients in disadvantaged communities had lower chances of receiving timely PCI and a greater risk of mortality and readmission compared with those in more advantaged communities. These findings suggest a need for targeted interventions to influence where cardiac services exist and who has access to them.
New Users of Angiotensin II Receptor Blocker–Versus Angiotensin‐Converting Enzyme Inhibitor–Based Antihypertensive Medication Regimens and Cardiovascular Disease Events: A Secondary Analysis of ACCORD‐BP and SPRINT
Authors: King Jordan B. , Berchie Ransmond O. , Derington Catherine G. , Marcum Zachary A. , Scharfstein Daniel O. , Greene Tom H. , Herrick Jennifer S. , Jacobs Joshua A. , Zheutlin Alexander R. , Bress Adam P. , Cohen Jordana B. 
Published: August 2023

BACKGROUND
Angiotensin II receptor blockers (ARBs) and angiotensin‐converting enzyme inhibitors (ACEIs) block distinct components of the renin‐angiotensin system. Whether this translates into differential effects on cardiovascular disease events remains unclear.

METHODS AND RESULTS

We used the ACCORD‐BP (Action to Control Cardiovascular Risk in Diabetes–Blood Pressure) trial and the SPRINT (Systolic Blood Pressure Intervention Trial) to emulate target trials of new users of ARBs versus ACEIs on cardiovascular disease events (primary outcome) and death (secondary outcome). We estimated marginal cause‐specific hazard ratios (HRs) and treatment‐specific cumulative incidence functions with inverse probability of treatment weights. We identified 3298 new users of ARBs or ACEIs (ACCORD‐BP: 374 ARB versus 884 ACEI; SPRINT: 727 ARB versus 1313 ACEI). For participants initiating ARBs versus ACEIs, the inverse probability of treatment weight rate of the primary outcome was 3.2 versus 3.5 per 100 person‐years in ACCORD‐BP (HR, 0.91 [95% CI, 0.63–1.31]) and 1.8 versus 2.2 per 100 person‐years in SPRINT (HR, 0.81 [95% CI, 0.56–1.18]). There were no appreciable differences in pooled analyses, except that ARBs versus ACEIs were associated with a lower death rate (HR, 0.56 [95% CI, 0.37–0.85]). ARBs were associated with a lower rate of the primary outcome among subgroups of male versus female participants, non‐Hispanic Black versus non‐Hispanic White participants, and those randomly assigned to standard versus intensive blood pressure (
P
interaction
: <0.01, 0.05, and <0.01, respectively).

CONCLUSIONS
In this secondary analysis of ACCORD‐BP and SPRINT, new users of ARB‐ versus ACEI‐based antihypertensive medication regimens experienced similar cardiovascular disease events rates, with important subgroup differences and lower rates of death overall.

REGISTRATION

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT01206062, NCT00000620.
Risk and Prognosis of Cancer in Patients With Cerebral Venous Thrombosis Compared With the Danish General Population
Authors: Skajaa Nils , Farkas Dóra Körmendiné , Adelborg Kasper , Sørensen Henrik Toft 
Published: August 2023

BACKGROUND:
Whether cerebral venous thrombosis (CVT) is a marker of cancer in clinical practice remains unknown. Little is known about the prognosis of cancer detected subsequent to CVT.

METHODS:
We used Danish nationwide registries (1996–2019) to identify patients with a first-time primary inpatient diagnosis of CVT without a history of cancer (N=811, 65% women, median age 42 years). We assessed the risk of an incident cancer diagnosis using standardized incidence ratios (SIRs). This measure contrasts the number of observed cancers among patients with CVT to the number of expected cancers where patients with CVT have the same cancer risk as the general population. We used Kaplan-Meier survival analysis and Cox regression to compare the survival of patients with both cancer and CVT with the survival of patients with cancer but without CVT, matched on cancer site, sex, age, and year of cancer diagnosis.

RESULTS:
Observing 43 incident cancer cases during follow-up, the overall SIR was unity (SIR, 1.04 [95% CI, 0.75–1.40]). However, the risk was ≈7-fold the expected level in the first 3 months following CVT diagnosis (SIR, 7.00 [95% CI, 3.02–13.80]) and ≈2-fold the expected level from 3 to 12 months following CVT diagnosis (SIR, 2.21 [95% CI, 0.89–4.56]). By 12 months following CVT diagnosis, the risk resembled the expected level (SIR, 0.76 [95% CI, 0.50–1.09]). Survival among cancer patients with prior CVT versus cancer patients without prior CVT was 91% versus 87% after 6 months and 65% versus 70% after 5 years. The adjusted hazard ratio of death was 0.78 (95% CI, 0.44–1.38).

CONCLUSIONS:
Patients with CVT were not at overall increased risk of a cancer diagnosis, except in the first 3 months after diagnosis during which period the risk was elevated ≈7-fold. The estimate from this early period, however, was based on only a few cancer diagnoses. Unlike other forms of venous thrombosis, a prior diagnosis of CVT did not negatively impact cancer survival.
New and additional records of Anacroneuria Klapálek (Plecoptera: Insecta) from Tocantins state, Brazil
Authors: RIPPEL MELLIS LAYRA SOARES , SALLES FREDERICO FALCÃO , FERNANDES ANDRÉ SILVA , KROLOW TIAGO KÜTTER 
Published: August 2023

In this study we provide an updated list of Plecoptera based on recent collections covering areas from northern to southeastern Tocantins state, Brazil. It is the first work focused on the geographical distribution of the order in this region. Herein, we register Anacroneuria atrifrons Klapálek, 1922, Anacroneuria jaciara Bispo & Neves, 2005, Anacroneuria manauensis Ribeiro-Ferreira, 2001, and Anacroneuria terere Righi-Cavallaro & Lecci, 2010 for the first time to Tocantins with notes and illustrations of diagnostic features for these four species. Our work raises the number of stoneflies known from Tocantins to 13 species. Despite this increase in the number of species, we highlight the importance of expanding field collection efforts in different locations of the state, especially in the west and south regions, as well as increasing collection effort in each location, aiming for a better comprehension of this fauna.
HAPLN1 matrikine: a bone marrow homing factor linked to poor outcomes in patients with MM
Authors: Chang Hae Yeun , Huynh Mailee , Roopra Avtar , Callander Natalie S. , Miyamoto Shigeki 
Published: August 2023

Abstract
The bone marrow (BM) microenvironment is critical for dissemination, growth, and survival of multiple myeloma (MM) cells. Homing of myeloma cells to the BM niche is a crucial step in MM dissemination, but the mechanisms involved are incompletely understood. In particular, any role of matrikines, neofunctional peptides derived from extracellular matrix proteins, remains unknown. Here, we report that a matrikine derived from hyaluronan and proteoglycan link protein 1 (HAPLN1) induces MM cell adhesion to the BM stromal components, such as fibronectin, endothelial cells, and stromal cells and, furthermore, induces their chemotactic and chemokinetic migration. In a mouse xenograft model, we show that MM cells preferentially home to HAPLN1 matrikine–conditioned BM. The transcription factor STAT1 is activated by HAPLN1 matrikine and is necessary to induce MM cell adhesion, migration, migration-related genes, and BM homing. STAT1 activation is mediated by interferon beta (IFN-β), which is induced by NF-κB after stimulation by HAPLN1 matrikine. Finally, we also provide evidence that higher levels of HAPLN1 in BM samples correlate with poorer progression-free survival of patients with newly diagnosed MM. These data reveal that a matrikine present in the BM microenvironment acts as a chemoattractant, plays an important role in BM homing of MM cells via NF-κB–IFN-β–STAT1 signaling, and may help identify patients with poor outcomes. This study also provides a mechanistic rationale for targeting HAPLN1 matrikine in MM therapy.
Source Quantitative Identification by Reference-Based Cubic Blind Deconvolution Algorithm
Authors: Luo Xin , Zhang Zhousuo , Gong Teng , Li Yongjie 
Published: August 2023

AbstractThe semi-blind deconvolution algorithm improves the separation accuracy by introducing reference information. However, the separation performance depends largely on the construction of reference signals. To improve the robustness of the semi-blind deconvolution algorithm to the reference signals and the convergence speed, the reference-based cubic blind deconvolution algorithm is proposed in this paper. The proposed algorithm can be combined with the contribution evaluation to provide trustworthy guidance for suppressing satellite micro-vibration. The normalized reference-based cubic contrast function is proposed and the validity of the new contrast function is theoretically proved. By deriving the optimal step size of gradient iteration under the new contrast function, we propose an efficient adaptive step optimization method. Furthermore, the contribution evaluation method based on vector projection is presented to implement the source contribution evaluation. Numerical simulation analysis is carried out to validate the availability and superiority of this method. Further tests given by the simulated satellite experiment and satellite ground experiment also confirm the effectiveness. The signals of control moment gyroscope and flywheel were extracted, respectively, and the contribution evaluation of vibration sources to the sensitive load area was realized. This research proposes a more accurate and robust algorithm for the source separation and provides an effective tool for the quantitative identification of the mechanical vibration sources.
Low-intensity transcranial ultrasound stimulation modulates neural activities in mice under propofol anaesthesia
Authors: Liu Meiqi , Yuan Yi , Wang Xingran , Wang Teng , Bian Nannan , Zhao Li , Cui Guangying , Liu Wenchao , Ma Zhongfeng , Yang Xiaochun , Liang Shujuan , Liu Zhuo 
Published: August 2023

Abstract
Background
Previous studies have reported that transcranial focused ultrasound stimulation can significantly decrease the time to emergence from intraperitoneal ketamine-xylazine anaesthesia in rats. However, how transcranial focused ultrasound stimulation modulates neural activity in anaesthetized rats is unclear.

Methods
In this study, to answer this question, we used low-intensity transcranial ultrasound stimulation (TUS) to stimulate the brain tissue of propofol-anaesthetized mice, recorded local field potentials (LFPs) in the mouse motor cortex and electromyography (EMG) signals from the mouse neck, and analysed the emergence and recovery time, mean absolute power, relative power and entropy of local field potentials.

Results
We found that the time to emergence from anaesthesia in the TUS group (20.3 ± 1.7 min) was significantly less than that in the Sham group (32 ± 2.6 min). We also found that compared with the Sham group, 20 min after low-intensity TUS during recovery from anaesthesia, (1) the absolute power of local field potentials in mice was significantly reduced in the [1–4 Hz] and [13–30 Hz] frequency bands and significantly increased in the [55–100 Hz], [100–140 Hz] and [140–200 Hz] frequency bands; (2) the relative power of local field potentials in mice was enhanced at [30–45 Hz], [100–140 Hz] and [140–200 Hz] frequency bands; (3) the entropy of local field potentials ([1-200 Hz]) was increased.

Conclusion
These results demonstrate that low-intensity TUS can effectively modulate neural activities in both awake and anaesthetized mice and has a positive effect on recovery from propofol anaesthesia in mice.
Poor preoperative performance at Clock Drawing Test is associated with postoperative decline in olfaction in older patients: an observational pilot study
Authors: Van Regemorter Victoria , Coulie Richard , Dollase Jordi , Momeni Mona , Stouffs Alexandre , Quenon Lisa , Mouraux André , Huart Caroline 
Published: August 2023

Abstract
Background
Decline in olfaction may occur after general anesthesia, but the exact incidence and underlying physiopathology remain scarcely investigated. Olfactory dysfunction arises with aging and is known to be linked to cognitive impairment. In this pilot study, we evaluated the incidence of immediate postoperative decline in olfaction and its association with a preoperative cognitive test, performance at Clock Drawing Test (CDT), in a group of older patients.

Methods
This pilot study is a sub-analysis of a prospective observational study. Patients ≥ 65 years old and scheduled for elective non-cardiac surgery under sevoflurane-based anesthesia were enrolled. CDT was part of the preoperative evaluation. We assessed olfaction on the day before and the day after surgery (between 16 and 26 h postoperatively) using the Sniffin’ Sticks 12-item identification test, which consists of pen-like devices displaying 12 different odors. Postoperative decline in olfaction was defined as a decrease of at least 1 standard deviation in the olfactory score.

Results
We included a total of 93 patients, among whom 19 (20.4%) presented a postoperative decline in olfaction. The incidence of postoperative decline in olfaction was higher in the “CDT low-score” (score ≤ 5/8) group (11/34, 32.4%) than in the “CDT high-score” (score ≥ 6/8) group (8/58, 13.6%) (P = 0.030). Despite adjusting for confounding variables, CDT score remained independently associated with immediate postoperative decline in olfactory identification function (OR 0.67, 95% CI 0.48 to 0.94, P = 0.022).

Conclusions
Postoperative decline in olfaction occurred in 20.4% of older patients and was associated with poor preoperative performance at CDT.

Trial registration
This study was retrospectively registered on https://clinicaltrials.gov/ under the NCT04700891 number (principal investigator: Victoria Van Regemorter), in December 2020.
Value of gym-based group exercise versus usual care for young adults receiving antipsychotic medication: study protocol for the multicenter randomized controlled Vega trial
Authors: Rafn Bolette Skjødt , Andersen Martin Færch , Sørensen Victor , Bjerre Eik Dybboe , Baandrup Lone , Vernal Ditte Lammers , Mors Ole , Knop Filip Krag , Wolf Rasmus Trap , Tolver Anders , Firth Joseph , Nøhr Nikolaj , Skou Søren T. , Ebdrup Bjørn H. , Midtgaard Julie 
Published: August 2023

Abstract
Background
Exercise is recommended to protect physical health among people with severe mental illness and holds the potential to facilitate long-term recovery. An inclusive exercise community provides an opportunity for life skill training and social connectedness and may reduce the experience of loneliness and internalized stigmatization which together may improve personal recovery. Using a pragmatic randomized design, we aim to examine the effectiveness of a gym-based exercise intervention tailored to young adults in antipsychotic treatment (i.e., Vega Exercise Community) compared to usual care. It is hypothesized that the Vega Exercise Community will be superior to usual care for personal recovery at four months.

Methods
The trial will be conducted at four sites in Denmark from which 400 participants, aged 18 to 35 years, who are in current treatment with antipsychotic medications for the management of schizophrenia spectrum or affective disorders, will be recruited. Participants will be randomized (2:1) to Vega Exercise Community or usual care. Vega Exercise Community includes three weekly group-based exercise sessions hosted in commercial functional training centers delivered by certified Vega instructors. After four months, participants in Vega Exercise Community will be randomized (1:1) to minimal versus extended support with regards to sustained physical activity. Data will be collected at baseline, four, six and 12 months. The primary outcome is personal recovery assessed by Questionnaire about the Process of Recovery at four months. Behavioral symptoms, health-related quality of life, metabolic health, and program costs will be evaluated to further determine the effectiveness and cost-effectiveness of the Vega Exercise Community. Finally, the quality of life and physical and mental health of the participants’ primary relative will be evaluated.

Discussion
The results of this trial may have important implications for health, sustained physical activity, and recovery for individuals in treatment with antipsychotics. Given the pragmatic design, positive results may readily be implemented by mental health care professionals to promote exercise as an integrated part of treatment of severe mental illness.

Trial registration
Clinical Trials.gov (NCT05461885, initial registration June 29th, 2022). WHO Universal Trial Number (UTN): U1111-1271–9928.