bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective evaluation of “critical view of safety” in laparoscopic cholecystectomy
Authors: Liu Pan , Hang Xu , Li Min , Li JiaRong , Xiaohua Dai 
Published: May 2023

Abstract
Objective
The value of critical view of safety (CVS) for laparoscopic cholecystectomy (LC) was evaluated using retroactive surgical video recording and clinical data.
Methods
172 patients who underwent LC in our center from January 2022 to December 2022 were selected and the complete operation video was retained. By reviewing the surgical video and clinical data, patients were divided into CVS group and unfinished CVS (U-CVS) group, comparing patients with different cholecystitis severity, gallbladder mesangial anatomy, bile duct injury(BDI), operation time, postoperative bile leakage and hospital length between the two groups. Performed logistic regression analysis on the risk factors of U-CVS in GRADE II/III (moderate/severe)cholecystitis, ROC curve was drawn to determine its predictive value.
Results
The proportion of LC achieving CVS in the center was 70.93% (122 /172), and the proportion of GRADE I, II and III cholecystitis patients was 85.98%, 49.12% and 25.00%, respectively. Compared with GRADE I group, the exposure rates of gallbladder mesangium (48.57% vs 80%), gallbladder neck / blood vessel (42.86% vs73.33%) in GRADE II / III group were lower, and the intraoperative bile duct injury (2.85%vs0%) was higher. The preoperative WBC > 18×109/L, BMI > 24kg/m2, previous gallbladder puncture, bile duct variation and incarceration of gall bladder neck stones were independent risk factors of U-CVS. ROC analysis showed that the above risk factors had good predictive performance(0.851).
Conclusion
CVS can reduce the incidence of IBD. Mild cholecystitis is prone to operate, while operation for moderate and severe cholecystitis is difficult, which is affected by preoperative WBC > 18×109/L, BMI > 24kg/m2, past history of gallbladder puncture, variation of bile duct and stones incarceration of gall bladder neck and other factors.
Risk factors and Outcome Analysis of Delayed Neurological Sequelae in elderly patients with carbon monoxide poisoning
Authors: Ma Yuehong , Xue Ruijun , Hu Huijun , Pan Shuyi , Guo Dazhi 
Published: May 2023

Abstract
Objective Carbon monoxide (CO) poisoning is one of the common causes of poisoning in patients and can result in significant neurological sequelae. However, few studies have focused on the elderly population.
Method We retrospectively reviewed elderly (age≥60 years) with CO poisoning from non-fire accidents and non-suicid at at the 6th medical center PLA general hospital in China from 2013 to 2023. We analyzed the patients’ epidemiological characteristics and outcome; identified the risk factors for patients who developed delayed neurological sequelae (DNS) and long-term neurological sequelae (LNS); compared the data of patients who received hyperbaric oxygen (HBO) to those who received normobaric oxygen (NBO) therapy.
Result A total of 167 elderly patients were enrolled. The annual case number decreased from 2013 to 2023, particularly during the cold months (November to February). The most common source of exposure was coal heating (89.8%). The most common presenting symptoms were consciousness changes (86.8%). Eighty-eight patients (52.3%) developed DNS, of which sixty-nine patients (78.4%) converted to LNS. The most common imaging manifestations were hypoxic ischemic damage in the basal ganglia (54.3%) and demyelination in white matter (45.7%). After multivariate analysis, initial GCS score and coma time were the independent risk factor for patients with DNS (p＜0.001). Interestingly, myocardial injury was more common in non DNS elderly patients than in DNS patients (p＜0.001); only coma time was an independent risk factor for patients with LNS (p＜0.001). There was no significant difference between HBO (p=0.196) and NBO (p=0.379) in the occurrence of DNS and LNS in elderly patients with CO poisoning.
Conclusion: Only initial GCS score and coma time are the risk factors of DNS for elderly patients, and coma time alone is a high-risk factor for poor prognosis of CO poisoning in the elderly. Moreover, HBO is not superior to NBO in elderly patients with CO poisoning. Special attention should be given and follow-up should be performed to elderly patients, particularly those have longer coma time and CO exposure time, and lower initial GCS score in acute CO poisoning.
Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in the primary care setting. A prospective randomized, controlled and multicentre pilot study in primary care
Authors: Känel Roland , Neuner-Jehle Stefan , Kressig Reto W. , Guessous Idris , Krayenbühl Pierre Alexandre , Zimmerli Lukas , Angelilo-Scherer Anne , Keller Thomas , Elzner Caroline , Pauls Karl , Morin Neige , Battegay Edouard 
Published: May 2023

Abstract
Objective Unexplained fatigue is a common reason for encounter in the primary care setting, with currently no structured tool available to support diagnosis. This study evaluated the effects of the novel Fatigue Differential Diagnostic Aid (FDDA) in clinical practice.
Design This was a prospective, randomized, controlled, multicentre study comparing use of the FDDA vs usual care in patients with unexplained fatigue as the main reason for encounter.
Setting and Participants The study included 93 patients seen in the primary care setting (FDDA n=40, usual care n=53) in Switzerland.
Outcomes Patient Global Impression of Change (PGIC), patient satisfaction with treatment and fatigue improvement, treatment patterns, number of examinations, number of visits.
Results There was no statistically significant group difference for the primary endpoint of PGIC. However, five predefined endpoints met statistical significance: (1) More patients were very satisfied with treatment management in the FDDA group at both 1 month (FDDA 56.8% vs usual care 25.6%, p=0.004) and 3 months (FDDA 64.9% vs usual care 31%, p=0.003); (2) patients underwent more examinations at baseline in the FDDA group (median 11.0 for FDDA vs 7.0 for usual care, p=0.002); (3) The FDDA group received a wider range of, and more treatments at 1 month, but less iron replacement therapy (p=0.0233); the FDDA was also associated with (4) a higher total number of visits (median 4.0 vs 3.0, p <0.001), and (5) more patients reporting reduced fatigue after 3 or 6 months (FDDA 97.4% vs usual care 78.4%, p=0.011).
Conclusions The FDDA has the potential to improve the management of fatigue. The findings of this study may be relevant to clinical practice because physicians using the FDDA investigated the causes of fatigue more extensively, and more patients reported reduced fatigue. Further studies on diagnostic tools for unexplained fatigue are warranted.
Early Cambrian Protomelission is a scleritomous eumetazoan but not a bryozoan or dasyclad alga
Authors: Xiang Kai , Liu Wei , Zhao Fangchen , Zhu Maoyan , Yin Zongjun 
Published: May 2023

Abstract
The origin of Bryozoa has long been an intriguing mystery, largely due to the dearth of unambiguous bryozoan fossils within Cambrian strata1-5. Recently reported earliest bryozoan Protomelission 2, an early Cambrian phosphatized microfossil from Australia and China, was subsequently contested and proposed as calcified dasyclad algae1. Our re-analysis of raw micro-CT data from Protomelission specimens, however, unveils previously unrevealed structures, indicating Protomelission to be neither bryozoan nor alga, but almost a complete scleritome of Cambroclavus, an early Cambrian microfossil typically found as disarticulated sclerites. The long-awaited scleritomes suggest that enigmatic cambroclaves likely represent an extinct group of epitheliozoan-grade eumetazoan, with spiny sclerites covering their epidermis for defense. The prevalence of bizarre animals like cambroclaves, lacking modern analogues, implies a greater disparity of animal body plans during the Cambrian Explosion than previously understood. Our findings underscore the absence of definitive early Cambrian bryozoan fossils, further highlighting the dilemma of the origin of Bryozoa.
Predictive value of dynamic contrast-enhanced-MRI-based machine learning model for lymphovascular invasion status in node-negative invasive breast cancer
Authors: Liang Rong , Tong fang , Hua M , Liu Junjun , Li Fangfang , Shi Chenlei , Sui Lewen , Yao Jingyuan , Lu Hong 
Published: May 2023

Abstract
Purpose
To retrospectively evaluate breast magnetic resonance imaging (MRI)-based machine learning (ML) model that can preoperatively predict lymphovascular invasion (LVI) status in invasive breast cancer patients with negative axillary lymph nodes (LNs).
Methods
We retrospectively enrolled 280 patients who underwent pre-operative breast MRI and were confirmed with invasive breast cancer by surgical pathology, with absence of axillary LN metastasis. This cohort included 148 LVI-positive lesions and 141 LVI-negative lesions, randomly divided (7:3) into training and validation cohort. The tumor segmentation from the first postcontrast dynamic contrast-enhanced (DCE)-MRI was semi-automatically implemented using 3D Slicer 5.1.0 software, and radiomics features of each lesion were extracted. Least absolute shrinkage and selection operator (LASSO) regression method was used to select the significant radiomics features, and five different ML algorithms were used to build models. A clinical model was also built and integrated with the radiomics models. The predictive performance of models were evaluated by discrimination and compared using DeLong test.
Results
A total of 4 clinico‑radiological parameters and 10 selected radiomics features were selected for model construction. The RF model that was built based on the radiomics and clinico‑radiological feature information exhibited the best predictive performance, yielding high AUC (0.97 for train and 0.82 for validation, respectively). The integrated model significantly outperformed the clinical model, whereas showed no significant difference from the radiomics model.
Conclusions
The RF model integrating radiomics features with clinical information facilitate LVI detection in invasive breast cancer patient with negative axillary LNs preoperatively, which was valuable for clinical decision-making.
Impact of Refractance Window drying method on physical properties and phenolic antioxidants of tomato powder in comparison with other methods
Authors: Zomorodi Shahin , Hedayat Aida 
Published: May 2023

Abstract
In this study, the quality properties of tomato powder prepared using the Refractance Window (RW) drying method was compared with microwave, hot air and sun drying methods. The bulk density, water solubility, vitamin C, total polyphenol compounds, optical density and color index of tomato powders were determined. The results of statistical analysis showed that the vitamin C content, phenolic compounds and solubility of samples dried by microwave and RW methods were significantly higher than the other methods (p<0.05). The lowest and the highest bulk density belonged to the powders prepared by microwave and RW respectively. In samples dried by RW method, L*, b* and a* index and color score was higher and the optical density was lower than other samples. The samples dried in microwave had the lowest L* value and highest optical density value, while the b* and a* index in these sample have been higher than the samples dried by sun and hot air drying methods. Also the lowest and the highest Hue and Chroma value were found in samples dried in hot air and RW respectively, while a*/b* ratio was reversed. But the highest and the lowest the total color (ΔE) value was in the samples dried in sun and RW method respectively. All in all, it can be concluded that the Refractance Window method can be used as a suitable alternative to hot air and microwave drying methods, without undesired effects on quality properties of tomato powders.
Active tectonic deformation in the central-lower courses of Cai River, Khanh Hoa Province, Central Vietnam and its significance for the evolution of river and associated geological hazards
Authors: Tran Hai Thanh , Bui Hau Vinh , Ngo Chi Kim Thi , Phan Binh Van , Nguyen Hung Quoc , Ngo Thanh Xuan , Nguyen Nam Xuan , Hoang Do Tu Ngo , Vu Dao Anh , Nguyen Hiep Huu , Vu Linh Thai 
Published: May 2023

Abstract

The east-west trending middle and lower courses of the Cai River, central Vietnam, are underlain by a geologically complicated basement, which was strongly deformed by multiphase tectonic activities. Active tectonism is intensely, indicated by wide-spread brittle faulting, fracturing, significant uplifting or subsidence, and other tectono-geomorphological indicators, that systematically modify landscapes, drainage systems, and enhanced geological hazards such as landslides, riverbanks erosions, and coastal erosions. These, in conjunction with basement heterogeneity, have governed the evolution of the drainage network in the area. Active faulting forces the channels/currents to flow along the fault zones. The transecting of strike-slip faults across the flows leads to diversion of the flow orientation and formed complex flow patterns as well as pull-apart basins. Dip-slip motions of fault walls resulted in the formation of local uplift and/or subsidence blocks. In uplifted areas, the lowering of the base-level leads to incision and rejuvenation of the channels with a deep gorge, a step V-shape valley, and a widening of the beach. The subsidence led to a relative base-level rise, leading to lateral erosion, bankcuts and the windings of river course and formation of oxbow lake/lagoons, as well as erosion of the shoreline. In addition, uneven uplift and subsidence produce local tectonic tilting, resulting in the migration of flow towards the subsided areas. In this case, the pronounced uplifting of the south side of Cai River Valley has led to northeasterly tectonic tilting, which has forced the main flow and its mouth to migrated northeastward periodically, abandoned of older flows in the south and created an uneven north side-down river
Design and Analysis of Hanger Irrigation System
Authors: Sawant Rohit V. , Chavan Sachin S. 
Published: May 2023

Abstract
This research aims to evaluate the effectiveness of a newly designed hanger irrigation system in providing consistent water supply for agriculture in India. With agriculture being a crucial sector for the country's economic development and a significant source of livelihood for about 70% of the population, water scarcity poses a significant challenge. Traditional irrigation methods have limitations, necessitating the exploration of alternative systems that are durable and affordable. The hanger irrigation system was developed using SolidWorks software, incorporating Finite Element Analysis to enhance its vibrational sustainability and reduce deformation. The structure utilized structural steel and bamboo fiber as materials, with vibration and static analyses conducted using ANSYS 19 software to ensure stability and improve load-bearing capacity. Cost comparisons were made between bamboo and steel models. The findings of modal and static analyses for different materials were discussed to draw conclusions. Effective water management in irrigation is essential for maximizing crop productivity and meeting food production goals in India. The hanger irrigation system shows promise in providing consistent water supply while minimizing labor costs, making it a viable alternative for agricultural irrigation.
A cross-chain model with underlying security and scalability based on quantum algorithm
Authors: Wang Zhuo , Li Jian , Liu Ang , Hou Yanyan 
Published: May 2023

Abstract
As a typical cross-chain technology, the relay chain is widely applied. The transaction security in the cross-chain application of a traditional relay chain depends on the reliability of the relay part, which relies on the autonomous performance of the relay chain. However, this will lead to the risk of trust breach. There are three main security concerns: 1) No security access control for authentication; 2) Consensus transmission depends on the authority of the relay node; 3) Potential security threats from quantum computing attacks. To tackle these issues, a quantum cross-chain model (QCC) is proposed to provide post-quantum security. The QCC offers an access control policy for the global identity of application chains and two-way authentication for the cross-chain network, and a secure solution that deploys a quantum ring signature scheme (QRS) provided with audit and key-loss security for cross-chain transactions, contributing to decentralization, reliability, consensus transmissionand security of the relay chain. From a system security perspective, the security of QCC is enhanced by the underlying cryptographic algorithm--QRS, eliminating under-layer attacks and bringing a stronger guarantee for the security and scalability of upper-layer applications. In addition, the model has the advantage of scalability and supports multi-party transactions.
The Social Groups and Decline of a Southwestern Clovis Network
Authors: Wendorf M. A. 
Published: May 2023

Abstract

Shared lithic raw materials were used to map a ca. 13,000-year-old Clovis regional social network, labelled the Cochise Clovis network, that connected the Murray Springs Clovis site to Clovis assemblages in southern Arizona, southwestern New Mexico and northern Sonora, Mexico. The network retained evidence of the foraging party, seasonal aggregation, and periodic aggregation social grouping layers of a Clovis band. With numerous small nodes that coexisted with a few hubs, the link distribution of the network was consistent with a power law. The network initially extended into the Sonoran Desert to the west but subsequently declined from this region in response to a severe drought. The decline of the western portion of the network could have been asymmetric and characterized by errors. Copious flint knapping at Murray Springs presented opportunities to discuss the status of existing links using first-hand information during a time of network decline.
The 3’ non-coding sequence negatively regulates PD-L1 expression and its regulators are systematically identified in pan-cancer
Authors: Chen Zike , Pi Hui , Wang Zhiyang , Zhang Yingdan , Zhang Jie , Xu Jintai , Qu Xuanhao , Liu Lehan , Shen Haoliang , Lu Yang , Chen Miaomiao , Zhang Weibing , Mao Renfang , Sun Rong , Fan Yihui 
Published: May 2023

Abstract
Objective Comparing to the coding sequences (CDS), the 3’-untranslated region (3’-UTR) of PD-L1 is extremely longer but its role and regulators are less explored.Methods The whole 3’-UTR region was deleted by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was performed using Timer and Xcell package. Immunotherapy response prediction and cox regression were performed using R software. MicroRNA network analysis was conducted by Cytoscape software.Results The level of PD-L1 was dramatically and significantly up-regulated in 3’-UTR deficient cells. Furthermore, we found a panel of 43 RNA binding proteins (RBPs) that correlated with PD-L1 in a majority of cancer cell lines and tumor tissues. Among them, PARP14 is widely associated with immune checkpoints, tumor microenvironment and immune infiltrating cells in various cancer types. We also identified 38 MicroRNA that associated with PD-L1 across cancers. The miR-3139, miR-4761 and miR-15a-5p are significantly associated with PD-L1 in most of cancer types. Finally, we revealed 21 m6A regulators that have a strong correlation with PD-L1. More importantly, by combing the identified RBPs and m6A regulators, we established a predictive immune signature including RBMS1, QKI, YTHDC1, ZC3HAV1, RBM38 and PPARGC1B to predict the responsiveness of cancer patients upon receiving immune checkpoint blockade.Conclusions We demonstrated the critical role of 3’-UTR in the regulation of PD-L1 and uncovered a large number of potential PD-L1 regulators in pan-cancer. The generated biomarker signature has power to predict patient’s prognosis, but along with the potential PD-L1 regulators should be further biologically investigated.
Prognostic factors of non-functioning pancreatic neuroendocrine neoplasms after curative surgery and risk factors for liver recurrence
Authors: Shintakuya Ryuta , Uemura Kenichiro , Sumiyoshi Tatsuaki , Seo Shingo , Okada Kenjiro , Otsuka Hiroyuki , Baba Kenta , Murakami Yoshiaki , Serikawa Masahiro , Ishii Yasutaka , Arihiro Koji , Takahashi Shinya 
Published: May 2023

Abstract
Purpose
This study aimed to identify the prognostic factors of non-functioning pancreatic neuroendocrine neoplasms (NF-PNENs) after curative surgery and evaluate the risk factors for liver recurrence in patients with NF-PNENs.
Methods
We retrospectively analysed clinicopathological data from 1993 to 2021 to determine predictors of poor overall survival (OS) and disease-free survival (DFS) and risk factors for liver recurrence after curative surgery in patients with NF-PNENs. Independent factors associated with survival and liver recurrence were identified using multivariate analysis.
Results
Of the 107 consecutive patients with pancreatic neuroendocrine neoplasms who underwent surgical resection, 78 who underwent curative surgery were eligible for this study. The median postoperative follow-up time was 58.1 months. The 5-year OS and DFS were 90.7% and 86.8%, respectively. Eight (10%) patients had imaging findings of recurrence, with liver recurrence being the most frequent (n = 7). In multivariate analysis, lymph node metastasis (LNM) (P = 0.026) was the only independent predictor of poor OS and DFS. Moreover, LNM (P = 0.036) was the only independent risk factor for liver recurrence.
Conclusion
LNM was independently associated with poor prognosis in patients with NF-PNENs after curative surgery. LNM was the only independent risk factor for liver recurrence, which is a haematogenous metastasis. Therefore, systemic treatment may help prevent distant metastases and prolong the prognosis.
A pan-genome of 72 Arabidopsis thaliana accessions reveals a conserved genome structure throughout the global species range
Authors: Lian Qichao , Hüttel Bruno , Walkemeier Birgit , Mayjonade Baptiste , Lopez-Roques Celine , Gil Lisa , Roux Fabrice , Schneeberger Korbinian , Mercier Raphael 
Published: May 2023

Abstract
Although originally primarily a model for functional biology, the thale cress Arabidopsis thaliana has, owing to its broad geographical distribution and adaptation to diverse abiotic and biotic environments, developed into a powerful model in population genomics. Here, we present chromosome-level genome assemblies of 72 diverse accessions located across the global species range. We found that genomic co-linearity is remarkably conserved, even among geographically and genetically distant accessions. Along chromosome arms, megabase-scale rearrangements are rare, typically present only in a single accession. This indicates that the highly re-arranged karyotype of Arabidopsis thaliana (as compared to other Brassicaceae species), is quasi-fixed and that rearrangements in chromosome arms are counter-selected. In contrast, centromeric regions show much higher structural dynamics, and divergences in core centromeres account for most of the variation in genome size. Pan-genome analyses of the gene space uncovered 40,382 distinct genes, 52% being present in all accessions and 48% appearing to be dispensable, including 23% private to a single accession, indicating a vast unexplored genic diversity. The availability of 72 new Arabidopsis thaliana genome assemblies will empower future genetic research.