bluuebunny/crossref_metadata_2025_split huggingface dataset:
Montreal soundscapes during the COVID-19 pandemic: A spatial analysis of noise complaints and residents’ surveys
Authors: Trudeau Christopher , Tarlao Cynthia , Guastavino Catherine 
Published: July 2023

Abstract
Public health measures during the COVID-19 pandemic provided researchers with a quasi-experimental situation to examine what happens when anthropogenic noise sources (e.g., traffic) are greatly reduced. This article combines noise-related calls to Montreal’s 311 service (29,891 calls from 2014 to 2022) with original survey data from 240 residents collected in 2020 after the lockdown and the summer reopening. The spatial analysis of the calls revealed that, across all pandemic phases, noise complaints increased with population density, the proportion of low-income residents, and the proportion of greenspace. However, the change in the spatial distribution of noise-related calls due to the pandemic measures is positively associated with the proportions of residential and greenspace land use. That is, areas with higher proportions of residential land use and greenspace experienced the greatest increase in noise-related calls. The analysis of the survey revealed that the sounds of traffic and construction decreased during both the lockdown and the subsequent reopening, while the sounds of the neighborhood and nature increased. However, the decreased traffic noise in the downtown core also allowed for the emergence of noise from the heating, ventilation and air conditioning systems in the area. We discuss these results considering the interest in reducing noise levels in cities.
Application of waste recycle tire steel fibers as a construction material in concrete
Authors: Amin Muhammad Nasir , Khan Kaffayatullah , Nazar Sohaib , Deifalla Ahmed Farouk 
Published: July 2023

Abstract
A bulk volume of waste tires, an underrated global resource, is disposed of in landfills worldwide. Extracting recycled steel fibers from these tires is an evolving trend nowadays. The outcomes of concrete having steel fibers sourced from end-of-life tires are alike industrial steel fibers. Accordingly, the attention of researchers is focused nowadays on using alternative recycled steel fibers in place of industrial steel fibers in concrete. In the current study, the review focuses on waste recycle tire steel fiber (WRTSF)-reinforced concrete applications, considering different lengths and contents for finding the research gap in this research domain. The results and methods to recycle WRTSFs in existing studies are compiled and briefed. The adoption of appropriate composition and characteristics like length, diameter, content, etc., of WRTSFs can be made by using this study to improve the mechanical properties of respective composites. Therefore, the aim of this evaluation is to encourage the application of concrete reinforced with WRTSF for different construction purposes, including but not limited to pavements, tunnel linings, bridge decks, hydraulic structures, and slope stabilization. The study seeks to provide guidance on the appropriate composition and characteristics of WRTSFs to improve the mechanical properties of the composite material.
RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells
Authors: Joseph Ivor , Flores Juan , Farrell Victoria , Davis Justin , Bianchi‐Smak Jared , Feng Qiang , Goswami Sayantani , Lin Xiang , Wei Zhi , Tong Kevin , Feng Zhaohui , Verzi Michael P , Bonder Edward M , Goldenring James R , Gao Nan 
Published: July 2023

AbstractRAB11 small GTPases and associated recycling endosome have been localized to mitotic spindles and implicated in regulating mitosis. However, the physiological significance of such regulation has not been observed in mammalian tissues. We have used newly engineered mouse models to investigate intestinal epithelial renewal in the absence of single or double isoforms of RAB11 family members: Rab11a and Rab11b. Comparing with single knockouts, mice with compound ablation demonstrate a defective cell cycle entry and robust mitotic arrest followed by apoptosis, leading to a total penetrance of lethality within 3 days of gene ablation. Upon Rab11 deletion ex vivo, enteroids show abnormal mitotic spindle formation and cell death. Untargeted proteomic profiling of Rab11a and Rab11b immunoprecipitates has uncovered a shared interactome containing mitotic spindle microtubule regulators. Disrupting Rab11 alters kinesin motor KIF11 function and impairs bipolar spindle formation and cell division. These data demonstrate that RAB11A and RAB11B redundantly control mitotic spindle function and intestinal progenitor cell division, a mechanism that may be utilized to govern the homeostasis and renewal of other mammalian tissues.
Propuestas de actividades para el estudio de la distribución geográfica de los suelos
Authors: Molina Condú Yilian , Carrillo Menocal Héctor , Díaz Garriz Diana Rosa , Vazquez Quintana Lisbet Catalina 
Published: July 2023

La Geografía como ciencia, estudia la relación de disimiles hechos, fenómenos y procesos que se llevan a cabo en el espacio geográfico, contribuyendo a la formación de una cultura geográfica, que fomente visiones integradoras de la realidad. El presente artículo tiene como propósito la propuesta de actividades que permitan explicar la distribución geográfica de los suelos en el proceso de enseñanza aprendizaje de la Geografia en décimo grado, lo cual posibilitará adquirir conocimientos que permitan explicar los hechos fenómenos y procesos que le rodean, desarrollen habilidades y se apropien de modos de actuación responsables. Se utilizaron los métodos y técnicas de investigación: inductivo-deductivo, analítico-sintético, el análisis de documentos, la entrevista, el criterio de especialistas y la triangulación de datos.
Factors Supporting Workplace Learning in Vietnam
Authors: Hai Nguyen Thi , Xuan Bui Thanh , Oanh Duong Thi , Thu Nguyen Hoai , Thanh Pham Van 
Published: July 2023

Learning in the workplace is a fundamental component of lifelong learning, valuable and significant for both employees and employers. Learning in the workplace helps employees improve their skills, qualifications, and labor productivity. Learning in the workplace also contributes to a culture of lifelong learning. In Vietnam, there have only been small-scale studies on the workplace learning activities of each group of learners. However, in each field and industry, there have been no direct studies on factors supporting learning in the workplace. This article has researched factors that support the workplace learning of cadres, civil servants, public employees, and employees in organizations in Vietnam. The paper conducts an overview of existing work to identify and focus research on four factors that support learning in the workplace with nine basic variables. From there, a survey of employees who have regularly studied at work in different fields, and organizations. Through the processing and analysis of survey results, this study uncovered several important issues about factors supporting workplace learning. This study found that: organizations already have factors that support learning in the workplace; Workers evaluate supporting variables to varying degrees. Besides, the level of support for these factors is different between organizations as well as localities. These results have great practical significance, helping employers have plans and policies to improve the quality of workplace learning
Endocrowns – a literature review
Authors: Ciobanu Paul , Manziuc Manuela-Maria , Buduru Smaranda Dana , Dudea Diana 
Published: July 2023

Introduction. The opportunity of using Endocrown-type restorations in the current prosthetic dentistry practice as an alternative to other, well-established methods of corono-radicular restorations and the evolving palette of adhesive materials has made these restorations more popular in the last few years.
Objective. The purpose is to review the available literature about Endocrown restorations regarding mechanical properties – fracture strength and resistance, survival rate, the preparation design – marginal and internal adaptation, and esthetics.
Method. The search was carried out on four databases: PubMed, Scopus (ScienceDirect), Web of Science, and Scielo using the following terms: ”endocrowns”, ”endodontic crown”, and” no buildup crown”. Initially, a total of 163 articles published between 2015 and May 2021 were selected. After the duplicates, papers presented only as abstracts, articles in any other languages except English, and review articles were eliminated; a total of 72 articles remained to be considered for this review.
After assessing the 72 considered articles, 37 were chosen as fit for this review. The reasons for the elimination of the other 35 articles were: their main focus was other than endocrowns, e.g., direct restorations, indirect restorations of vital teeth; case reports; study protocols.
Results. From the 37 articles selected, 34 were focused on mechanical properties, including the influence of the preparation design, and three on survival rate, of which one also had a point of view regarding esthetics.
Conclusions. The literature included in this review shows that endocrowns perform similarly or even better in some cases than other coronal restorations. However, this statement must be interpreted cautiously, given that most articles were in vitro or finite element analysis studies. Given the high degree of conflicting results found in the articles included in this review, the authors consider as reasonable to conclude that further studies are needed to confirm the feasibility of endocrowns and the best choice of material.
Finerenone Added to RAS/SGLT2 Blockade for CKD in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3 −/− Mice
Authors: Zhu Zhihui , Rosenkranz Karoline A.T. , Kusunoki Yoshihiro , Li Chenyu , Klaus Martin , Gross Oliver , Angelotti Maria-Lucia , Antonelli Giulia , Cirillo Luigi , Romagnani Paola , Bouteldja Nassim , Sadr Alireza Vafaei , Bülow Roman D. , Boor Peter , Anders Hans-Joachim 
Published: July 2023

Significance Statement
We hypothesized that triple therapy with inhibitors of the renin–angiotensin system (RAS), sodium–glucose transporter (SGLT)-2, and the mineralocorticoid receptor (MR) would be superior to dual RAS/SGLT2 blockade in attenuating CKD progression in Col4a3-deficient mice, a model of Alport syndrome. Late-onset ramipril monotherapy or dual ramipril/empagliflozin therapy attenuated CKD and prolonged overall survival by 2 weeks. Adding the nonsteroidal MR antagonist finerenone extended survival by 4 weeks. Pathomics and RNA sequencing revealed significant protective effects on the tubulointerstitium when adding finerenone to RAS/SGLT2 inhibition. Thus, triple RAS/SGLT2/MR blockade has synergistic effects and might attenuate CKD progression in patients with Alport syndrome and possibly other progressive chronic kidney disorders.

Background
Dual inhibition of the renin–angiotensin system (RAS) plus sodium–glucose transporter (SGLT)-2 or the mineralocorticoid receptor (MR) demonstrated additive renoprotective effects in large clinical trials. We hypothesized that triple therapy with RAS/SGLT2/MR inhibitors would be superior to dual RAS/SGLT2 blockade in attenuating CKD progression.

Methods
We performed a preclinical randomized controlled trial (PCTE0000266) in Col4a3-deficient mice with established Alport nephropathy. Treatment was initiated late (age 6 weeks) in mice with elevated serum creatinine and albuminuria and with glomerulosclerosis, interstitial fibrosis, and tubular atrophy. We block-randomized 40 male and 40 female mice to either nil (vehicle) or late-onset food admixes of ramipril monotherapy (10 mg/kg), ramipril plus empagliflozin (30 mg/kg), or ramipril plus empagliflozin plus finerenone (10 mg/kg). Primary end point was mean survival.

Results
Mean survival was 63.7±10.0 days (vehicle), 77.3±5.3 days (ramipril), 80.3±11.0 days (dual), and 103.1±20.3 days (triple). Sex did not affect outcome. Histopathology, pathomics, and RNA sequencing revealed that finerenone mainly suppressed the residual interstitial inflammation and fibrosis despite dual RAS/SGLT2 inhibition.

Conclusion
Experiments in mice suggest that triple RAS/SGLT2/MR blockade may substantially improve renal outcomes in Alport syndrome and possibly other progressive CKDs because of synergistic effects on the glomerular and tubulointerstitial compartments.
A PRUDÊNCIA COMO PRINCÍPIO NO PROJETO EDUCACIONAL DE ALBERTO MAGNO
Authors: Costa Larissa Moreira da , Oliveira Bruna Castelhano de , Oliveira Terezinha 
Published: July 2023

O objetivo deste artigo é apresentar o conceito de prudência em Alberto Magno (1200-1280), entendendo-o como base do seu projeto educacional. Nossa fonte principal de análise será o Tratado De prudentia contido na obra Tractatus de Natura Bono (1243). Nela o autor apresenta a necessidade da formação de uma sociedade baseada no bem comum, tendo como princípio de suas ações a virtude da prudência. Segundo o autor, esta virtude é considerada como a maior de todas as demais, pois tem como objetivo guiar o homem à escolha de boas ações que assegurem bem comum social. Partindo dessa máxima, procuraremos compreender quais seriam os princípios pedagógicos para a formação de um indivíduo virtuoso, segundo o filósofo. Em virtude dessa relevante questão, pretendemos também, refletir sobre a importância deste intelectual no âmbito da história da educação. Salientamos, também, que para a elaboração desse artigo, elegemos alguns princípios da história social apresentados no âmbito da Escola dos Annales e consideramos o conceito de longa duração elaborado por Braudel (1990) como aspectos teórico-metodológicos essenciais ao nosso estudo.
Posterior Cruciate Ligament Femoral Avulsion Fractures in Pediatric Patients
Authors: Chipman Danielle E. , Cirrincione Peter M. , Mintz Douglas N. , DiFelice Gregory S. , Warren Russell F. , Green Daniel W. 
Published: July 2023

Case:
This report describes 2 cases of femoral-sided posterior cruciate ligament (PCL) avulsion injuries. A 10-year-old male patient presented with a chronic nonunion of a bony PCL femoral avulsion. In addition, a 4-year-old boy presented with an acute, displaced PCL femoral avulsion off the medial femoral condyle. Both injuries were repaired using arthroscopic techniques.

Conclusion:
Femoral-sided PCL avulsions are very rare in pediatric patients and have not been reported often. We hope to increase the awareness of PCL femoral avulsion injuries in pediatric patients by describing 2 unique cases.
Praktik Standard Contract pada PT iGrow Resources Indonesia Fatwa DSN MUI terhadap Standard Contract
Authors: Nur Aini Latifah , Tanzilulloh M. Ilham , Sidik Moch. Khoirul Fajar 
Published: July 2023

The standard contract is in the Fatwa of DSN MUI Number 117/DSN-MUI//II/2018 concerning Information Technology-Based Financing Services Based on Sharia Principles. In practice, the standard contract of PT iGrow Resources Indonesia contradicts the fatwa on profit sharing, disclaiming responsibility in the event of a loss. The objectives of this study include: knowing that iGrow's profit sharing is fluctuating and knowing that iGrow's disclaimer is contrary to the fatwa of DSN MUI. This study uses qualitative research methods, with the object of field research. The analytical method used in this study is the deductive method. The results of this study are: 1) iGrow's profit sharing is contrary to DSN Fatwa No. 117, namely financing is not allowed to have an element of usury while iGrow. It sets the amount of profit with an absolute nominal, which can be equated with usury; 2) The form of iGrow's disclaimer is contrary to the Fatwa of the MUI DSN. The standard iGrow contract states that iGrow transfers its responsibility to the capital manager in the event of a loss.
Kontrak baku dalam Fatwa DSN MUI Nomor 117/DSN-MUI//II/2018 tentang Layanan Pembiayaan Berbasis Teknologi Informasi Berdasarkan Prinsip Syariah. Dalam prakteknya kontrak baku PT iGrow Resources Indonesia bertentangan dengan fatwa pada pembagian keuntungan, pelepasan tanggung jawab jika terjadi kerugian. Tujuan penelitian ini antara lain: mengetahui pembagian keuntungan iGrow bersifat fluktuatif dan mengetahui bentuk pelepasan tanggung jawan iGrow bertentangan dengan fatwa DSN MUI. Penelitian ini menggunakan metode penelitian kualitatif, dengan objek penelitian lapangan. Metode analisis yang digunakan dalam penelitian kali ini adalah metode deduktif. Hasil dari penelitian ini adalah: 1) Pembagian keuntungan iGrow bertentangan dangan Fatwa DSN No 117 yaitu pembiayaan tidak diperbolehkan ada unsur riba sementara iGrow menetapkan jumlah keuntungan dengan nominal mutlak, ini dapat dipersamakan dengan riba; 2) Bentuk pelepasan tanggung jawab iGrow bertentangan dengan Fatwa DSN MUI. Dalam kontrak baku iGrow disebutkan bahwa iGrow mengalihkan tanggung jawabnya kepada pengelola modal apabila terjadi kerugian.
Evaluation of the Anti-diarrhoeal, Anti-inflammatory, and Analgesic Effects of the Polyherbal Formulation, Aju Mbaise in Experimental Rats.
Authors: Uroko Robert Ikechukwu , Ijioma Solomon Nnah , Ogbonna Henry Nnaemeka , Aguwamba Chinedu , Ugwuanyi Kingsley Chijioke 
Published: July 2023

Abstract

Background:Aju Mbaiseis a combination of herbs that is widely used in the southeast part of Nigeria for the purpose of managing postpartum complications and alleviating menstrual pain. The study aimed at assessing the analgesic, anti-inflammatory, and anti-diarrheal properties ofAju mbaiseextract in rats. Methods: The extract was subjected to phytochemical analysis and acute toxicity testing. Subsequently, the anti-diarrheal effects of the extract were evaluated by administering charcoal as a meal and then using the castor oil-induced models. The evaluation of its anti-inflammatory effects was conducted through the carrageenan-induced paw oedema model, while its analgesic properties were assessed using the acetic acid-induced pain model. Results: Alkaloids, tannins, phenols, steroids, cardiac glycosides, terpenoids, flavonoids, and saponins were among the components that the phytochemical study revealed to be present. The acute toxicity value was also greater than 5000 mg/kg body weight. In animal studies, the extract displayed significant inhibitory effects on intestinal motility, while also reducing the wet stool frequency. The castor oil-induced model exhibited a decrease in the weight of intestinal contents and an elevation in serum electrolyte levels. Additionally, in the anti-inflammatory study, the extract was observed to suppress paw oedema, and in the analgesic study, it demonstrated a reduction in acetic acid-induced pain in rats. Conclusions: TheAju mbaisepolyherbal extract possesses anti-diarrhoeal, anti-inflammatory, and analgesic properties, making it a potentially safe option for managing diarrhoea, inflammation, and pain. These therapeutic effects may be attributed to the extract's composition of alkaloids, tannins, phenols, steroids, cardiac glycosides, terpenoids, flavonoids, and saponins. Nonetheless, additional research is necessary to establish the extract's ideal dosages and potential adverse effects.
Measuring and Manipulating Defect-induced Micro-electronic Fields at Metal-Support Interface
Authors: Fu Engang , Wei Yi , Zhang Zichang , Du Jinlong , Xu Chuan , Sun Qiang , Chen Zhenyu , Wang Yufei 
Published: July 2023

Abstract
Tunning the micro-electric field at the metal-support interface offers great opportunities for developing heterogeneous catalysts with high stability, selectivity, and activity. However, the role of carbon support defects plays in manipulating the charge transfer process and activating the interfacial perimeter sites is still obscure due to the absence of direct experimental evidence. Herein, we develop a top-down method to synthesize a metal-defective-support model via both heavy ion irradiation and chemical impregnation. The interface electric field distribution, together with the magnitude of charge density distribution were reconstructed and visualized in the real space via four-dimension scanning transmission electron microscopy (4D-STEM).Combining the density functional theory (DFT) calculations, we further reveal the carbon topological defects induced atomic scale polarization mechanism is responsible for the reversed charge transfer behavior and demonstrate that the metal-support interaction could be precisely manipulated through controlling support defects density. This work offers new insights for understanding defects’ function of elevating the catalyst stability and performance, and facilitating the future development of advanced catalysts with high activity.
Hierarchical design of pseudosymmetric protein nanoparticles
Authors: Baker David , Dowling Quinton , Park Young-Jun , Gerstenmaier Neil , Yang Erin , Wargacki Adam , Hsia Yang , Fries Chelsea , Ravichandran Rashmi , Walkey Carl , Burrell Anika , Veesler David , King Neil 
Published: July 2023

Abstract

Discrete protein assemblies ranging from hundreds of kilodaltons to hundreds of megadaltons in size are a ubiquitous feature of biological systems and perform highly specialized functions 1–3. Despite remarkable recent progress in accurately designing new self-assembling proteins, the size and complexity of these assemblies has been limited by a reliance on strict symmetry 4,5. Inspired by the pseudosymmetry observed in bacterial microcompartments and viral capsids, we developed a hierarchical computational method for designing large pseudosymmetric self-assembling protein nanomaterials. We computationally designed pseudosymmetric heterooligomeric components and used them to create discrete, cage-like protein assemblies with icosahedral symmetry containing 240, 540, and 960 subunits. At 49, 71, and 96 nm diameter, these nanoparticles are the largest bounded computationally designed protein assemblies generated to date. More broadly, by moving beyond strict symmetry, our work represents an important step towards the accurate design of arbitrary self-assembling nanoscale protein objects.