bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support
Authors: Yang Weiguang , Conover Timothy A. , Figliola Richard S. , Giridharan Guruprasad A. , Marsden Alison L. , Rodefeld Mark D. 
Published: August 2023

AbstractPatients with single ventricle defects undergoing the Fontan procedure eventually face Fontan failure. Long-term cavopulmonary assist devices using rotary pump technologies are currently being developed as a subpulmonary power source to prevent and treat Fontan failure. Low hydraulic resistance is a critical safety requirement in the event of pump failure (0 RPM) as a modest 2 mmHg cavopulmonary pressure drop can compromise patient hemodynamics. The goal of this study is therefore to assess the passive performance of a viscous impeller pump (VIP) we are developing for Fontan patients, and validate flow simulations against in-vitro data. Two different blade heights (1.09 mm vs 1.62 mm) and a blank housing model were tested using a mock circulatory loop (MCL) with cardiac output ranging from 3 to 11 L/min. Three-dimensional flow simulations were performed and compared against MCL data. In-silico and MCL results demonstrated a pressure drop of < 2 mmHg at a cardiac output of 7 L/min for both blade heights. There was good agreement between simulation and MCL results for pressure loss (mean difference − 0.23 mmHg 95% CI [0.24–0.71]). Compared to the blank housing model, low wall shear stress area and oscillatory shear index on the pump surface were low, and mean washout times were within 2 s. This study demonstrated the low resistance characteristic of current VIP designs in the failed condition that results in clinically acceptable minimal pressure loss without increased washout time as compared to a blank housing model under normal cardiac output in Fontan patients.
Ultrafast inactivation of SARS-CoV-2 by 254-nm UV-C irradiation on porous and non-porous media of medical interest using an omnidirectional chamber
Authors: Maubert Bertrand , Theillière Camille , Jany Prescillia , Bourlet Thomas , Deschamps Jérôme , Pozzetto Bruno , Singh Fateh , Gadea Emilie 
Published: August 2023

AbstractCovid-19 has spurred a renewed interest in decontamination techniques for air, objects and surfaces. Beginning in 2020, urgent effort was done to permit the reuse of UV-C for inactivating SARS-CoV-2. However, those studies diverged widely on the dose necessary to reach this goal; until today, the real value of the sensitivity of the virus to a 254-nm illumination is not known precisely. In this study, decontamination was performed in an original UV-C large decontamination chamber (UVCab, ON-LIGHT, France) delivering an omnidirectional irradiation with an average dose of 50 mJ/cm2 in 60 s. Viral inactivation was checked by both cell culture and PCR test. SARS-CoV-2 was inactivated by UV-C light within 3 s on both porous (disposable gown) and non-porous (stainless steel and apron) surfaces. For the porous surface, an irradiation of 5 min was needed to achieve a completely negative PCR signal. The Z value estimating the sensitivity of SARS-CoV-2 to UV-C in the experimental conditions of our cabinet was shown to be > 0.5820 m2/J. These results illustrate the ability of this apparatus to inactivate rapidly and definitively high loads of SARS-CoV-2 deposited on porous or non-porous supports and opens new perspectives on material decontamination using UV-C.
The effect of maternal educational status, antenatal care and resumption of menses on postpartum contraceptive use in Ethiopia: systematic review and meta-analysis
Authors: Gebeyehu Natnael Atnafu , Tegegne Kirubel Dagnaw , Kassaw Mesfine Wudu 
Published: August 2023

AbstractThe postpartum period is a crucial starting point for the delivery of family planning services. To date, there are numerous primary studies in Ethiopia on postpartum contraceptive use and related factors. However, the results of key variables are inconsistent, making it difficult to use the results to advance the service dimensions of postpartum contraceptive use in the country. Therefore, this systematic review and meta-analysis was required to summarize this inconsistency and compile the best available evidence on the impact of maternal educational status, antenatal care and menstrual resumption on postpartum contraceptive use in Ethiopia. PubMed, Google Scholar, Scopus, Science Direct, and the repositories of online research institutes were searched. Data were extracted with Microsoft Excel and analyzed with the statistical software STATA (version 14). Data on the study area, design, population, sample size, and observed frequency were extracted using the Joanna Briggs Institute tool. To obtain the pooled effect size, a meta-analysis was performed using a weighted inverse variance random effects model. Cochran's Q X2 test, and I2 statistics were used to test for heterogeneity, estimate the total quantity, and measure the variability attributed to heterogeneity. A mixed-effects meta-regression analysis was performed to identify possible sources of heterogeneity. To examine publication bias, the Eggers regression test and the Beggs correlation test were used at a p-value threshold of 0.001. Of the 654 articles reviewed, 18 studies met the inclusion criteria and were included in this meta-analysis. Overall, the final analysis includes 11,263 study participants. In Ethiopia, postpartum contraceptive use correlated significantly with maternal educational status (OR = 3.121:95% CI 2.127–4.115), antenatal care follow-up (OR = 3.286; 95% CI 2.353–4.220), and return of the mother's menses (OR = 3.492; 95% CI 1.843–6.615). A uniform meta-regression was performed based on publication year (p = 0.821), sample size (p = 0.989), and city of residence (p = 0.104), which revealed that none of these factors are significant. The use of postpartum contraceptives was found to be better among mothers who are educated, attended antenatal appointments, and resumed their menstrual cycle. Based on our research, we strongly recommended that antenatal care use and maternal educational accessibility need to improve. For family planning professionals, removing barriers to menstruation resumption should be a key priority.
Overlooking probabilistic mapping renders urban flood risk management inequitable
Authors: Bodoque José M. , Esteban-Muñoz Álvaro , Ballesteros-Cánovas Juan A. 
Published: August 2023

AbstractCharacterizing flood-related hazards has mostly relied on deterministic approaches or, occasionally, on particular uncertainty sources, resulting in fragmented approaches. To analyze flood hazard uncertainties, a fully integrated floodplain modeling information system has been developed. We assessed the most relevant uncertainty sources influencing the European Floods Directive’s third cycle (2022–2027) concerning extreme flood scenarios (a 500-year flood) and compared the results to a deterministic approach. Flood hazards outputs noticeably differed between probabilistic and deterministic approaches. Due to flood quantiles and floodplain roughness characterization, the flood area is highly variable and subject to substantial uncertainty, depending on the chosen approach. Model convergence required a large number of simulations, even though flow velocity and water depth did not always converge at the cell level. Our findings show that deterministic flood hazard mapping is insufficiently trustworthy for flood risk management, which has major implications for the European Floods Directive’s implementation.
The Impact of Telehealth on the Efficacy of Sound Production Treatment
Authors: Kallhoff Lydia , Mauszycki Shannon , Rose Brooke , Wambaugh Julie 
Published: August 2023

Purpose:
This investigation was designed to systematically examine the acquisition, maintenance, and response generalization effects of Sound Production Treatment (SPT) delivered via telehealth in comparison to existing in-person outcomes for SPT.

Method:
A multiple-baseline design across behaviors and participants was used with two individuals with chronic apraxia of speech (AOS) and aphasia. Accuracy of target speech sounds in treated and untreated words within phrases served as the dependent variable.

Results:
Both participants demonstrated positive gains for treatment and generalization items. Participant 1 demonstrated gains for both sets of treatment items with the application of treatment, but production accuracy at 2 and 6 weeks posttreatment was inconsistent. Participant 2 demonstrated large gains for both sets of treatment items with good maintenance at 2 and 6 weeks posttreatment. Effect sizes for both participants were similar to the traditional (in-person) SPT effect size benchmarks.

Conclusions:
The positive outcomes from this study indicate that individuals with AOS can benefit from SPT delivered via telehealth. These findings warrant further research examining the effects of SPT through telehealth and should include individuals with AOS with varying severity. This investigation serves as the first telehealth study to systematically examine treatment outcomes for SPT.
Normaldruckhydrozephalus
Authors: Kehler Uwe , Hattingen Elke 
Published: August 2023

ZusammenfassungFür Diagnostik, Differenzialdiagnostik und Differenzialtherapie des Normaldruckhydrozephalus ist die Bildgebung entscheidend. Auch wenn die Therapie eines Normaldruckhydrozephalus nicht
erfolgreich sein sollte, werden zahlreiche Fragen an den Radiologen gestellt. Der Artikel gibt eine Übersicht über das Krankheitsbild des Normaldruckhydrozephalus und die speziellen prä- und
postchirurgischen Anforderungen an die Bildgebung.
Systemtherapie des Peniskarzinoms – neue Konzepte? Neue Erfolge?
Authors: Hakenberg Oliver , Dräger Desiree Louise 
Published: August 2023

Zusammenfassung
Die systemische Chemotherapie wird seit Jahren mit beim metastasierten Peniskarzinom angewandt, jedoch nur mit begrenztem Erfolg. Ihre Bedeutung liegt überwiegend im Rahmen der multimodalen Therapie bei lymphogener Metastasierung in Zusammenhang mit radikaler Lymphknotenchirurgie. Bei begrenztem Lymphknotenbefall kann die Kombination von operativer Therapie mit cisplatin- und taxanhaltigen Dreifachkombinationen kurativ sein.

Fortschritte im Verständnis der molekularen Veränderungen beim Peniskarzinom und die Suche nach potenziellen Therapietargets haben zur Auflegung zahlreicher Studien geführt. Trotz Hinweisen auf die Wirksamkeit von Immuntherapeutika haben sich bislang jedoch keine wesentlichen therapeutischen Verbesserungen für die klinische Praxis ergeben.
Organerhaltende Therapie als wichtigste Option in der Behandlung des Primärtumors des Peniskarzinoms
Authors: Protzel Chris , Kutschke Richard , Eckert Marie-Luise 
Published: August 2023

Zusammenfassung
Die Therapie des Peniskarzinoms stellt eine relevante Herausforderung für Therapeuten wie für Patienten dar. Dabei muss der Schwerpunkt nicht nur auf operative Techniken, sondern sehr viel mehr auf Patienteninformation und gemeinsame Therapieplanung gelegt werden. Eine konsequente Aufklärung über möglichen Organerhalt und dessen Konsequenzen ist erforderlich. Nach klinischer Untersuchung und histologischer Sicherung des Befundes sollte in fast allen Fällen organerhaltendes stadienadaptiertes OP-Verfahren genutzt werden. Intraoperativ ist einer Sicherung tumorfreier Schnittränder mittels Schnellschnittuntersuchung anzustreben. Eine psychoonkologische Mitbetreuung soll allen Patienten angeboten werden.
Eine Zentralisierung der Therapie erscheint aufgrund der exzellenten Ergebnisse in
englischen wie niederländischen Zentren auch für Deutschland unbedingt wünschenswert. Bis
dahin kann in Anlehnung an die sehr guten Erfahrungen des Zweitmeinungsnetzwerks Hodentumor
die Zweitmeinungsplattform eKonsil Urologie (https://www.ekonsil.org) genutzt werden.
Eine Applikation für die rheumatologische Versorgung:
RheCORD
Authors: Welcker Martin , Klennert Michael , Aries Peer , Bartz-Bazzanella Peter , Von der Decken Cay , Engelbrecht Matthias , Gauler Georg , Hornig Johannes , Karberg Kirsten , Kuhn Christoph , Schuch Florian , Späthling-Mestekemper Susanna , Vorbrüggen Wolfgang , Wurth Patrick , Muth Theresia , Froschauer-Häfele Sonja , Mühlensiepen Felix , Popp Florian , Burigk Kristin , Kladny Heike , Kleinert Stefan 
Published: August 2023

ZusammenfassungHeutzutage haben medizinische Gesundheits-Applikationen (Apps) einen zunehmenden
Stellenwert. Auf nahezu jedem neuen Smartphone sind Gesundheits-Applikationen
installiert. RheCORD, eine medizinische Applikation in der Rheumatologie, wird
im Folgenden beschrieben und im medizinischen Kontext bewertet.
Einsatzmöglichkeiten,Vorteile und Limitationen werden beschrieben.
POINT: Pipeline for Offline Conversion and Integration of Geocodes and Neighborhood Data
Authors: Guo Kevin , McCoy Allison B. , Reese Thomas J. , Wright Adam , Rosenbloom Samuel Trent , Liu Siru , Russo Elise M. , Steitz Bryan D. 
Published: August 2023

Abstract
Objectives Geocoding, the process of converting addresses into precise geographic coordinates, allows researchers and health systems to obtain neighborhood-level estimates of social determinants of health. This information supports opportunities to personalize care and interventions for individual patients based on the environments where they live. We developed an integrated offline geocoding pipeline to streamline the process of obtaining address-based variables, which can be integrated into existing data processing pipelines.
Methods POINT is a web-based, containerized, application for geocoding addresses that can be deployed offline and made available to multiple users across an organization. Our application supports use through both a graphical user interface and application programming interface to query geographic variables, by census tract, without exposing sensitive patient data. We evaluated our application's performance using two datasets: one consisting of 1 million nationally representative addresses sampled from Open Addresses, and the other consisting of 3,096 previously geocoded patient addresses.
Results A total of 99.4 and 99.8% of addresses in the Open Addresses and patient addresses datasets, respectively, were geocoded successfully. Census tract assignment was concordant with reference in greater than 90% of addresses for both datasets. Among successful geocodes, median (interquartile range) distances from reference coordinates were 52.5 (26.5–119.4) and 14.5 (10.9–24.6) m for the two datasets.
Conclusion POINT successfully geocodes more addresses and yields similar accuracy to existing solutions, including the U.S. Census Bureau's official geocoder. Addresses are considered protected health information and cannot be shared with common online geocoding services. POINT is an offline solution that enables scalability to multiple users and integrates downstream mapping to neighborhood-level variables with a pipeline that allows users to incorporate additional datasets as they become available. As health systems and researchers continue to explore and improve health equity, it is essential to quickly and accurately obtain neighborhood variables in a Health Insurance Portability and Accountability Act (HIPAA)-compliant way.
Association Between Diabetes and Personality Traits Among the Elderly
in China: A Latent Class Analysis
Authors: Xiong Peisheng , Ye Wanbao , Xiong Meijuan , Chen Kangkang , Xu Kai 
Published: August 2023

Abstract
Background The present study aimed to identify individuals with different
personalities using latent class analysis and further distinguish those with a
high risk of diabetes among different clusters.
Methods Data were utilized from a large-scale, cross-sectional
epidemiological survey conducted in 2018 across 23 provinces in China, employing
a multi-stage, stratified sampling technique. Latent class cluster analysis was
performed to identify distinct personality clusters based on a series of
variables concerning life attitudes. Logistic regression was used to calculate
adjusted odds ratios (AORs) after controlling for potential confounding
variables, including age, gender, body mass index, smoking status, alcohol
consumption, hypertension, and physical activity levels, to determine the
association between these groups and diabetes.
Results Four distinct personality clusters were identified, namely the
energy-poor (2.0%), self-domination (61.3%), optimistic
(21.3%), and irritable (15.4%) groups. The prevalence of
diabetes in these groups was 14.6%, 9.7%, 9.3%, and
11.6%, respectively. After adjusting for potential confounders, the
“energy-poor group” exhibited more odds of having diabetes as
compared to the “optimistic group” (AOR 1.683, 95%CI:
1.052–2.693; P=0.030).
Conclusion This study identified an energy-poor group of individuals with
a high risk of diabetes. Targeted interventions should consider the emotional
and personality characteristics of the elderly.
Palliative Care: From Global to Local Needs
Authors: Gómez García Wendy Cristhyna , Torres Núñez Marleni Regalada 
Published: August 2023

AbstractPalliative care (PC) is a comprehensive approach that focuses on improving the quality of life of patients and families that face fatal diseases by optimal minimization of suffering. Seventy-eight percent of patients who benefit from palliative support live in low-and-middle-income countries, where the access to these services is limited. Six percent of the patients are below the age of 15. The aim of this study is to review briefly the history of PC and its global challenges and indicate its impact and barriers in the Dominican Republic. A literature review in PubMed and analysis of the history of impact globally of PC and a remark of Dominican Republic local program. Some of the identifiable barriers are the limited support from authorities and health systems, the discomfort of healthcare staff in providing PC, the lack of knowledge, as well as experience, and team support. Not only do low-and-middle-income countries face these challenges, but also globally there is an urgency of the integration of PC services to the different healthcare systems to improve quality of life. This was experienced in the Dominican Republic when the first PC program started in 2012. Currently, local efforts are being made to increase the impact of the program and to make it accessible to more patients and families.
Comparative Evaluation of Postoperative Pain Scores and Opioid Consumption in Septorhinoplasty After Administration of Single-Dose Preemptive Paracetamol and Ibuprofen: A Randomized Controlled Trial
Authors: Alshehri Ali Abdullah 
Published: August 2023

Abstract
Introduction Septorhinoplasty operates on the nose's bone and cartilage and is ensued by severe postoperative pain.
Objective The objective of this study is to evaluate the effects of preoperative administration of intravenous (IV) paracetamol and ibuprofen on postoperative pain scores in patients undergoing septorhinoplasty.
Methods A total of 150 patients undergoing septorhinoplasty were randomly assigned into 3 groups with 50 patients in each group. The control group (group A) was administered 100 ml saline solution; the paracetamol group (group B) was administered 1,000 mg of IV paracetamol in 100 ml of saline solution; and the ibuprofen group (group C) was administered 800 mg of IV ibuprofen in 100 ml of saline solution before surgery. Opioid analgesics were employed to achieve postoperative analgesia. Postoperative pain was evaluated using the visual analogue scale (VAS). Postoperative opioid consumption and adverse effects were also recorded for each patient.
Results In comparison with group A, the score in the VAS of groups B and C was statistically lower in all the time intervals (p < 0.05). In the 1st and 6th hours postoperatively, group C's score in the VAS in was lower than that of group B (p < 0.05). In the control group, total opioid consumption was highest in all time intervals (p < 0.05). In group C, total opioid consumption was significantly lower than in group B in the 0 to 6 and 6 to 12 hours intervals. (p < 0.05).
Conclusion The single-dose preemptive administration of ibuprofen has a more profound postoperative analgesic effect than paracetamol in the first 6 hours after septorhinoplasty. After the first 6 hours postsurgery, there is no difference between ibuprofen and paracetamol in terms of analgesic effect.
Multidisciplinary Cognitive Function Assessment of Good versus Poor Performance in Children with Cochlear Implants: An Observational Cross-Sectional Study
Authors: Ibraheem Ola A. , Abdelghani Mohamed , Hassan Elham M. , El-Nebtity Nadia , Gad Nahlah H. 
Published: August 2023

AbstractIntroduction Despite the developing technology of cochlear implants (CIs), implanted prelingual hearing-impaired children exhibit variable speech processing outcomes. When these children match in personal and implant-related criteria, the CI outcome variability could be related to higher-order cognitive impairment.Objectives To evaluate different domains of cognitive function in good versus poor CI performers using a multidisciplinary approach and to find the relationship between these functions and different levels of speech processing.Methods This observational, cross-sectional study used the word recognition score (WRS) test to categorize 40 children with CIs into 20 good (WRS/65%) and 20 poor performers (WRS < 65%). All participants were examined for speech processing at different levels (auditory processing and spoken language) and cognitive functioning using (1) verbal tests (verbal component of Stanford-Binet intelligence [SBIS], auditory memory, auditory vigilance, and P300); and (2) performance tasks (performance components of SBIS, and trail making test).Results The outcomes of speech processing at different functional levels and both domains of cognitive function were analyzed and correlated.Speech processing was impaired significantly in poor CI performers. This group also showed a significant cognitive function deficit, in which the verbal abilities were more affected (in 93.5%) than in the good performers (in 69.5%). Moreover, cognitive function revealed a significant correlation and predictive effect on the CI speech outcomes.Conclusion Cognitive function impairment represented an important factor that underlies the variable speech proficiency in cochlear-implanted children. A multidisciplinary evaluation of cognitive function would provide a comprehensive overview to improve training strategies.