bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of SMEs’ R&D performances by machine learning for project selection
Authors: Yoo Hyoung Sun , Jung Ye Lim , Jun Seung-Pyo 
Published: May 2023

AbstractTo improve the efficiency of government-funded research and development (R&D) programs for small and medium enterprises, it is necessary to make the process of selecting beneficiary firm objective. We aimed to develop machine learning models to predict the performances of individual R&D projects in advance, and to present an objective method that can be utilized in the project selection. We trained our models on data from 1771 R&D projects conducted in South Korea between 2011 and 2015. The models predict the likelihood of R&D success, commercialization, and patent applications within 5 years of project completion. Key factors for predicting the performances include the research period and area, the ratio of subsidy to research budget, the firm’s region and venture certification, and the average debt ratio of the industry. Our models’ precisions were superior to qualitative expert evaluation, and the machine learning rules could be explained theoretically. We presented a methodology for objectively scoring new R&D projects based on their propensity scores of achieving the performances and balancing them with expert evaluation scores. Our methodology is expected to contribute to improving the efficiency of R&D investment by supplementing qualitative expert evaluation and selecting projects with a high probability of success.
Photogrammetry as a promising tool to unveil marine caves’ benthic assemblages
Authors: Pulido Mantas Torcuato , Roveta Camilla , Calcinai Barbara , Coppari Martina , Di Camillo Cristina Gioia , Marchesi Veronica , Marrocco Teo , Puce Stefania , Cerrano Carlo 
Published: May 2023

AbstractTraditionally, monitoring approaches to survey marine caves have been constrained by equipment limitations and strict safety protocols. Nowadays, the rise of new approaches opens new possibilities to describe these peculiar ecosystems. The current study aimed to explore the potential of Structure from Motion (SfM) photogrammetry to assess the abundance and spatial distribution of the sessile benthic assemblages inside a semi-submerged marine cave. Additionally, since impacts of recent date musselLithophaga lithophagaillegal fishing were recorded, a special emphasis was paid to its distribution and densities. The results of SfM were compared with a more “traditional approach”, by simulating photo-quadrats deployments over the produced orthomosaics. A total of 22 sessile taxa were identified, with Porifera representing the dominant taxa within the cave, andL. lithophagapresenting a density of 88.3 holes/m2. SfM and photo-quadrats obtained comparable results regarding species richness, percentage cover of identified taxa and most of the seascape metrics, while, in terms of taxa density estimations, photo-quadrats highly overestimated their values. SfM resulted in a suitable non-invasive technique to record marine cave assemblages. Seascape indexes proved to be a comprehensive way to describe the spatial pattern of distribution of benthic organisms, establishing a useful baseline to assess future community shifts.
Extracellular vesicles of trypomastigotes of Trypanosoma cruzi induce changes in ubiquitin-related processes, cell-signaling pathways and apoptosis
Authors: Cornet-Gomez Alberto , Retana Moreira Lissette , Kronenberger Thales , Osuna Antonio 
Published: May 2023

AbstractChagas disease is caused by the protozoan parasite Trypanosoma cruzi. The disease has an acute and a chronic phase in which approximately 30% of the chronic patients suffer from heart disease and/or gastrointestinal symptoms. The pathogenesis of the disease is multifactorial and involves the virulence of the strains, immunological factors and extracellular vesicles (EV) shed by the parasite which participate in cell–cell communication and evasion of the immune response. In this work, we present a transcriptomic analysis of cells stimulated with EV of the trypomastigote stage of T. cruzi. Results after EV-cell incubation revealed 322 differentially expressed genes (168 were upregulated and 154 were downregulated). In this regard, the overexpression of genes related to ubiquitin-related processes (Ube2C, SUMO1 and SUMO2) is highlighted. Moreover, the expression of Rho-GTPases (RhoA, Rac1 and Cdc42) after the interaction was analyzed, revealing a downregulation of the analyzed genes after 4 h of interaction. Finally, a protective role of EV over apoptosis is suggested, as relative values of cells in early and late apoptosis were significantly lower in EV-treated cells, which also showed increased CSNK1G1 expression. These results contribute to a better understanding of the EV-cell interaction and support the role of EV as virulence factors.
Identification of a new gibberellin receptor agonist, diphegaractin, by a cell-free chemical screening system
Authors: Nozawa Akira , Miyazaki Ryoko , Aoki Yoshinao , Hirose Reina , Hori Ryosuke , Muramatsu Chihiro , Shigematsu Yukinori , Nemoto Keiichirou , Hasegawa Yoshinori , Fujita Keiko , Miyakawa Takuya , Tanokura Masaru , Suzuki Shunji , Sawasaki Tatsuya 
Published: May 2023

AbstractGibberellin (GA) is a phytohormone that regulates various developmental processes during the plant life cycle. In this study, we identify a new GA agonist, diphegaractin, using a wheat cell-free based drug screening system with grape GA receptor. A GA-dependent interaction assay system using GA receptors and DELLA proteins fromVitis viniferawas constructed using AlphaScreen technology and cell-free produced proteins. From the chemical compound library, diphegaractin was found to enhance the interactions between GA receptors and DELLA proteins from grape in vitro. In grapes, we found that diphegaractin induces elongation of the bunch and increases the sugar concentration of grape berries. Furthermore, diphegaractin shows GA-like activity, including promotion of root elongation in lettuce and Arabidopsis, as well as reducing peel pigmentation and suppressing peel puffing in citrus fruit. To the best of our knowledge, this study is the first to successfully identify a GA receptor agonist showing GA-like activity in agricultural plants using an in vitro molecular-targeted drug screening system.
Thermal transport in warm dense matter revealed by refraction-enhanced x-ray radiography with a deep-neural-network analysis
Authors: Jiang S. , Landen O. L. , Whitley H. D. , Hamel S. , London R. , Clark D. S. , Sterne P. , Hansen S. B. , Hu S. X. , Collins G. W. , Ping Y. 
Published: May 2023

AbstractTransport properties of high energy density matter affect the evolution of many systems, ranging from the geodynamo in the Earth’s core, to hydrodynamic instability growth in inertial confinement fusion capsules. Large uncertainties of these properties are present in the warm dense matter regime where both plasma models and condensed matter models become invalid. To overcome this limit, we devise an experimental platform based on x-ray differential heating and time-resolved refraction-enhanced radiography coupled to a deep neural network. We retrieve the first measurement of thermal conductivity of CH and Be in the warm dense matter regime and compare our measurement with the most commonly adopted models. The discrepancies observed are related to the estimation of a correction term from electron-electron collisions. The results necessitate improvement of transport models in the warm dense matter regime and could impact the understanding of the implosion performance for inertial confinement fusion.
Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain β-amyloid pathology
Authors: Pan Fengfeng , Huang Yanlu , Cai Xiao , Wang Ying , Guan Yihui , Deng Jiale , Yang Dake , Zhu Jinhang , Zhao Yike , Xie Fang , Fang Zhuo , Guo Qihao 
Published: May 2023

Abstract
Background
Accurate prediction of cerebral amyloidosis with easily available indicators is urgently needed for diagnosis and treatment of Alzheimer’s disease (AD).

Methods
We examined plasma Aβ42, Aβ40, T-tau, P-tau181, and NfL, with APOE genotypes, cognitive test scores and key demographics in a large Chinese cohort (N = 609, aged 40 to 84 years) covering full AD spectrum. Data-driven integrated computational models were developed to predict brain β-amyloid (Aβ) pathology.

Results
Our computational models accurately predict brain Aβ positivity (area under the ROC curves (AUC) = 0.94). The results are validated in Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Particularly, the models have the highest prediction power (AUC = 0.97) in mild cognitive impairment (MCI) participants. Three levels of models are designed with different accuracies and complexities. The model which only consists of plasma biomarkers can predict Aβ positivity in amnestic MCI (aMCI) patients with AUC = 0.89. Generally the models perform better in participants without comorbidities or family histories.

Conclusions
The innovative integrated models provide opportunity to assess Aβ pathology in a non-invasive and cost-effective way, which might facilitate AD-drug development, early screening, clinical diagnosis and prognosis evaluation.
Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain
Authors: Czaplewski Lloyd G. , Zeitlinger Marcus , Standing Joseph F. 
Published: May 2023

AbstractOral coamoxiclav and amoxicillin, for extended dose regimens of up to 100 days, have shown benefit in the treatment of Chronic Lower Back Pain (CLBP) associated with vertebral bone oedema, known as Modic type 1 changes, which may be caused by a bacterial infection, but the magnitude of clinical improvement has been variable. The objectives of this review were to use sparse data from the literature to estimate the exposure of amoxicillin in the intervertebral disc, and to determine whether adequate antimicrobial exposure may have been achieved. Exposure to amoxicillin in herniated disc tissue was approximately 6.5% of the serum concentration. Dosing of oral amoxicillin, Q12h, at doses of up to 1,000 mg is unlikely to lead to effective exposure in disc tissue. Mean exposure to 500 mg or 750 mg of oral Q8h amoxicillin may reach the efficacy target for ~50% ofCutibacterium acnesstrains, but not for 90% ofC. acnesstrains. Mean exposure to 1,000 mg of oral amoxicillin Q8h may reach the target exposure for 90% of strains. Oral amoxicillin CLBP studies may all be underdosed. More than 1400 patients with CLBP and Modic type 1 changes have been exposed to oral amoxicillin for up to 100 days, with no apparent evaluation of systemic or intradiscal pharmacokinetics. Additional clinical evaluations of amoxicillin and alternative antibiotics, their dose regimens, and intradiscal pharmacokinetics are warranted to optimize treatment for this indication. Expertise in antibacterial pharmacokinetics and pharmacodynamics should be included in the design and execution of future studies.
An unusually low-density super-Earth transiting the bright early-type M-dwarf GJ 1018 (TOI-244)
Authors: Castro-González A. , Demangeon O. D. S. , Lillo-Box J. , Lovis C. , Lavie B. , Adibekyan V. , Acuña L. , Deleuil M. , Aguichine A. , Zapatero Osorio M. R. , Tabernero H. M. , Davoult J. , Alibert Y. , Santos N. , Sousa S. G. , Antoniadis-Karnavas A. , Borsa F. , Winn J. N. , Allende Prieto C. , Figueira P. , Jenkins J. M. , Sozzetti A. , Damasso M. , Silva A. M. , Astudillo-Defru N. , Barros S. C. C. , Bonfils X. , Cristiani S. , Di Marcantonio P. , González Hernández J. I. , Curto G. Lo , Martins C. J. A. P. , Nunes N. J. , Palle E. , Pepe F. , Seager S. , Suárez Mascareño A. 
Published: May 2023

Context. Small planets located at the lower mode of the bimodal radius distribution are generally assumed to be composed of iron and silicates in a proportion similar to that of the Earth. However, recent discoveries are revealing a new group of low-density planets that are inconsistent with that description.
Aims. We intend to confirm and characterize the TESS planet candidate TOI-244.01, which orbits the bright (K = 7.97 mag), nearby (d = 22 pc), and early-type (M2.5 V) M-dwarf star GJ 1018 with an orbital period of 7.4 days.
Methods. We used Markov chain Monte Carlo methods to model 57 precise radial velocity measurements acquired by the ESPRESSO spectrograph together with TESS photometry and complementary HARPS data. Our model includes a planetary component and Gaussian processes aimed at modeling the correlated stellar and instrumental noise.
Results. We find TOI-244 b to be a super-Earth with a radius of Rp = 1.52 ± 0.12 R⊕ and a mass of Mp = 2.68 ± 0.30 M⊕. These values correspond to a density of ρ = 4.2 ± 1.1 g cm−3, which is below what would be expected for an Earth-like composition. We find that atmospheric loss processes may have been efficient to remove a potential primordial hydrogen envelope, but high mean molecular weight volatiles such as water could have been retained. Our internal structure modeling suggests that TOI-244 b has a 479−96+128 km thick hydrosphere over a 1.17 ± 0.09 R⊕ solid structure composed of a Fe-rich core and a silicate-dominated mantle compatible with that of the Earth. On a population level, we find two tentative trends in the density-metallicity and density-insolation parameter space for the low-density super-Earths, which may hint at their composition.
Conclusions. With a 8% precision in radius and 12% precision in mass, TOI-244 b is among the most precisely characterized super-Earths, which, together with the likely presence of an extended hydrosphere, makes it a key target for atmospheric observations.
Acute Responses in Blood Flow Restriction Low-intensity Aerobic
Training: A Meta-analysis
Authors: de Queiros Victor Sabino , Rolnick Nicholas , Sabag Angelo , de França Ingrid Martins , Wilde Phelipe , Vieira João Guilherme , Reis Victor Machado , Formiga Magno F. , Cabral Breno Guilherme de Araújo Tinôco , Dantas Paulo Moreira Silva 
Published: May 2023

AbstractThe purpose was to determine the effect low-intensity training with blood flow
restriction (LI-BFR) versus high-intensity aerobic training (HIT) on acute
physiological and perceptual responses. The Cumulative Index to Nursing and
Allied Health Literature, National Library of Medicine, Scopus, SPORTDiscus and
Web of Science databases and the reference list of eligible studies were
consulted to identify randomized experimental studies, published until July 4,
2022, that analyzed physiological or perceptual responses between LI-BFR versus
HIT in healthy young individuals. Mean difference (MD) and standardized mean
difference (SMD) were used as effect estimates and random effects models were
applied in all analyses. Twelve studies were included in this review. During
exercise sessions, HIT promoted higher values of heart rate (MD=28.9
bpm; p<0.00001; I

2
=79%), oxygen
consumption (SMD=4.01; p<0.00001;
I

2
=83%), ventilation
(MD=48.03 l/min; p=0.0001;
I

2
=97%), effort (SMD=1.54;
p=0.003; I

2
=90%) and blood
lactate (MD=3.85 mmol/L; p=0.002;
I

2
=97%). Perception of
pain/discomfort was lower in HIT (SMD=−1.71;
p=0.04; I

2
=77.5%). In
conclusion, LI-BFR promotes less pronounced physiological responses than HIT but
with greater perception of pain.
Muscle Hypertrophy Responses to Changes in Training Volume: A Retrospective Analysis
Authors: de Camargo Júlio Benvenutti Bueno , Barbosa Paulo Henrique , Brigatto Felipe Alves , Braz Tiago Volpi , Lopes Charles Ricardo 
Published: May 2023

AbstractThis study assessed associations between changes in the weekly number of sets performed and the percentage change in muscle thickness of the biceps (MTBB) and triceps (MTTB) brachii muscles. Through a retrospective analysis, sixty-eight resistance-trained subjects that participated in previous studies had their previous training volumes analyzed and compared to the volume imposed during each individual study. The relationship between variables was determined through Spearman correlation and a k-cluster analysis was performed to subdivide the participants into three groups and classified as:<0%; 0–50%, and >50% increase in the number of sets for both muscle groups. Moderate and weak correlations were observed between the alterations in training volume and changes in MTBB (rs=0.44, p=0.001) and MTTB (rs=0.35, p=0.002), respectively. A significant difference was noted between<0% to >50% for MTBB and MTTB (p=0.017; p=0.042, respectively), while no significant difference was observed between<0% to 0–50% and 0–50% to >50% (both p >0.05) for both muscle groups. In conclusion, muscle hypertrophy of the upper limbs is only weakly to moderately associated with changes in training volume of trained subjects.
Sarcopenia, More Than Just Muscle Atrophy: Imaging Methods for the Assessment of Muscle Quantity and Quality
Authors: Vasilevska Nikodinovska Violeta , Ivanoski Slavcho 
Published: May 2023

Background Sarcopenia, a progressive reduction of muscle mass and function, is associated with adverse outcomes in the elderly. Sarcopenia and muscle atrophy are not equal processes. Low muscle strength in association with muscle quantity/quality reduction is currently the optimal method for assessing sarcopenia. There is a practical need for indirect measurement of muscle strength using state-of-the-art imaging techniques.Methods The following provides a narrative, broad review of all current imaging techniques for evaluating muscles and identifying sarcopenia, including DEXA, CT, MRI, and high-resolution ultrasound, their main strengths, weaknesses, and possible solutions to problems regarding each technique.Results and Conclusion Well-recognized imaging methods for the assessment of muscle mass are explained, including evaluation with DEXA, CT, and MRI muscle quantity assessment, ultrasound evaluation of muscle thickness and CSA, and their correlations with established muscle mass calculation methods. A special focus is on imaging methods for muscle quality evaluation. Several innovative and promising techniques that are still in the research phase but show potential in the assessment of different properties of muscle quality, including MRI DIXON sequences, MRI spectroscopy, Diffusion Tensor Imaging, ultrasound echo intensity, ultrasound elastography, and speed-of-sound ultrasound imaging are briefly mentioned.Key Points: Citation Format
Unexpected metallic foreign bodies on panoramic scans – a narrative review
Authors: Brauer Hans Ulrich , Bartols Andreas , Hellmann Daniel , Boldt Julian 
Published: May 2023

Background The digital panoramic radiograph (orthopantomogram, OPG) is the standard radiographic technique for basic diagnostics in dental practice. A correctly taken image provides a good overview of teeth and jaw, whereas radiopaque foreign materials, e. g. metal, can obscure relevant findings.
Methods A literature review on unexpected metallic foreign bodies in OPG was performed to determine the spectrum of metallic foreign bodies that may cause radiopaque areas on panoramic radiographs in routine clinical use.
Results and Conclusion A total of 37 different unexpected metallic foreign bodies were found. They can be categorized as jewelry, clothing, personal protective equipment, medical devices, iatrogenic foreign bodies, and rare incidental findings. Radiopaque foreign materials in the OPG are often relatively easy to recognize as artifacts because of their location, and they are avoidable in most cases. If unclear, a three-dimensional radiograph was helpful for determining the location. Radiopaque areas caused by foreign bodies can lead to misinterpretation or partial or complete non-evaluability and should therefore be avoided.
Key Points:
Citation Format
Modulation of Extravascular Binding of Recombinant Factor IX Impacts the Duration of Efficacy in Mouse Models
Authors: Pestel Sabine , Ponnuswamy Padmapriya , Machado Steffi Knoll , Peil Hendrik , Kraushaar Timo , Claar Philipp , Mischnik Marcel , Lind Holger , Herzog Eva , Bacher Michael , Nolte Marc Wolfgang , Bielohuby Maximilian 
Published: May 2023

Background There is an emerging concept that in addition to circulating coagulation factor IX (FIX), extravascular FIX contributes to hemostasis.
Objective Our objective was to evaluate the efficacy of extravascular FIX using animal models of tail clip bleeding and ferric chloride-induced thrombosis.
Methods Mutant rFIX proteins with described enhanced (rFIXK5R) or reduced (rFIXK5A) binding to extracellular matrix were generated and characterized using in vitro aPTT, one-stage clotting, and modified FX assays. Using hemophilia B mice, pharmacokinetic (PK) parameters and in vivo efficacy of these proteins were compared against rFIX wild-type protein (rFIXWT) in a tail clip bleeding and FeCl3-induced thrombosis model. Respective tissue disposition of FIX was evaluated using immunofluorescence.
Results In vitro characterization demonstrated comparable clotting activity of rFIX proteins. The PK profile showed that rFIXK5A displayed the highest plasma exposure compared to rFIXWT and rFIXK5R. Immunofluorescence evaluation of liver tissue showed that rFIXK5R was detectable up to 24 hours, whereas rFIXWT and rFIXK5A were detectable only up to 15 minutes. In the tail clip bleeding model, rFIXK5R displayed significant hemostatic protection against bleeding incidence for up to 72 hours postintravenous administration of 50 IU/kg, whereas the efficacy of rFIXK5A was already reduced at 24 hours. Similarly, in the mesenteric artery thrombus model, rFIXK5R and rFIXWT demonstrated prolonged efficacy compared to rFIXK5A.
Conclusion Using two different in vivo models of hemostasis and thrombosis, we demonstrate that mutated rFIX protein with enhanced binding (rFIXK5R) to extravascular space confers prolonged hemostatic efficacy in vivo despite lower plasma exposure, whereas rFIXK5A rapidly lost its efficacy despite higher plasma exposure.
Short Synthesis of a Biphenyl-Based Amino Triflamide Catalyst and Its Application in Enamine Catalysis
Authors: Kano Taichi , Uwaso Yuki , Yokoyama Naoki 
Published: May 2023

AbstractA novel axially chiral biphenyl-based amino triflamide has been designed and successfully synthesized from 1-nitropyrene in 6 steps. This chiral amino triflamide functions as effective catalyst for asymmetric Mannich reaction through enamine intermediates.
Measurement properties of the Brazilian Portuguese version of the Lower-Extremity Motor Activity Log for chronic hemiparetic poststroke patients
Authors: Menezes-Oliveira Elaine , Cecconi Marília Escudero , Oliveira Clarissa Barros de , Vegas Milena , Alouche Sandra Regina , Arida Ricardo Mario , Matuti Gabriela da Silva 
Published: May 2023

Abstract
Background Stroke is among the three leading causes of disability around the world, and it results in immediate difficulty in mobility and gait. There is a lack of instruments to evaluate what daily life is like for these individuals using their lower limbs in real-life environments (outside of the clinical environment).
Objective To perform the translation and cultural adaptation to Brazilian Portuguese of the Lower-Extremity Motor Activity Log (LE-MAL) and test its measurement properties in chronic poststroke individuals.
Methods The LE-MAL was translated into Brazilian Portuguese and adapted to the Brazilian culture. The comprehension and relevance of the final version were analyzed by a committee of specialists. The reliability, validity, and responsiveness of the LE-MAL/Brazil to detect changes after lower extremity constraint-induced movement therapy (LE-CIMT) and an intensive conventional therapy were tested.
Results The LE-MAL/Brazil showed excellent inter- and intrarater reliability, with an intraclass correlation coefficient and Cronbach alpha > 0.70, as well as standard error of measurement and smallest detectable change < 10% of the total instrument score when applied by the same evaluators.
Conclusion The responsiveness of the LE-MAL/Brazil to detect changes showed better results after LE-CIMT than after the intensive conventional therapy, with most of the correlations > 0.50.