bluuebunny/crossref_metadata_2025_split huggingface dataset:
PaPILO: A Parallel Presolving Library for Integer and Linear Optimization with Multiprecision Support
Authors: Gleixner Ambros , Gottwald Leona , Hoen Alexander 
Published: June 2023

Presolving has become an essential component of modern mixed integer program (MIP) solvers, both in terms of computational performance and numerical robustness. In this paper, we present PaPILO, a new C++ header-only library that provides a large set of presolving routines for MIP and linear programming problems from the literature. The creation of PaPILO was motivated by the current lack of (a) solver-independent implementations that (b) exploit parallel hardware and (c) support multiprecision arithmetic. Traditionally, presolving is designed to be fast. Whenever necessary, its low computational overhead is usually achieved by strict working limits. PaPILO’s parallelization framework aims at reducing the computational overhead also when presolving is executed more aggressively or is applied to large-scale problems. To rule out conflicts between parallel presolve reductions, PaPILO uses a transaction-based design. This helps to avoid both the memory-intensive allocation of multiple copies of the problem and special synchronization between presolvers. Additionally, the use of Intel’s Threading Building Blocks library aids PaPILO in efficiently exploiting recursive parallelism within expensive presolving routines, such as probing, dominated columns, or constraint sparsification. We provide an overview of PaPILO’s capabilities and insights into important design choices. History: Accepted by Ted Ralphs, Area Editor for Software Tools. Funding: This work has been financially supported by Research Campus MODAL, funded by the German Federal Ministry of Education and Research [Grants 05M14ZAM, 05M20ZBM], and the European Union’s Horizon 2020 research and innovation programme under grant agreement No 773897 (plan4res). The content of this paper only reflects the author’s views. The European Commission / Innovation and Networks Executive Agency is not responsible for any use that may be made of the information it contains. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0171 ), as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0171 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Nachhaltige Digitalisierung oder Nachhaltigkeit durch Digitalisierung?
Authors: Winkler Stefan , Günther Jochen , Pfennig Roland 
Published: June 2023

ZusammenfassungDigitalisierung und Nachhaltigkeit sind Megatrends des 21. Jahrhunderts mit hoher transformativer Kraft, die sich potenziell gegenseitig verstärken können. Bisher wurden beide Themen meist nur separat diskutiert und keine Strategien erarbeitet, die sich auf die inhaltliche Schnittmenge beziehen. Der Beitrag strukturiert die Korrelation beider Themen aus einer Unternehmensperspektive in eine nachhaltige Gestaltung der Digitalisierung (Stichwort „Green IT“ als Ressourceneffizienz, Energiesparsamkeit, etc.) sowie in den Einsatz der Digitalisierung für mehr Nachhaltigkeit (Stichwort „Green through IT“ in Form von Smart Services, Prozesseffizienz, Ressourcenschonung, etc.). Auf Basis der Auswertung von Unternehmensbeispielen aus verschiedensten Branchen im deutschen Raum wird in einem induktiven Ansatz ein praxisnahes Modell mit vier strategischen Handlungsoptionen mit Bezug auf die Twin Transformation für Unternehmen entwickelt (Corporate Digital Responsibility, Digitale Sozialprojekte, Geschäftsmodelle für eine nachhaltigere Digitalisierung, Digitale Geschäftsmodelle für mehr Nachhaltigkeit).
Susceptibility of Aedes albopictus, Ae. aegypti and human populations to Ross River virus in Kuala Lumpur, Malaysia
Authors: Fu Jolene Yin Ling , Chua Chong Long , Abu Bakar Athirah Shafiqah , Vythilingam Indra , Wan Sulaiman Wan Yusoff , Alphey Luke , Chan Yoke Fun , Sam I-Ching 
Published: June 2023

Background
Emerging arboviruses such as chikungunya and Zika viruses have unexpectedly caused widespread outbreaks in tropical and subtropical regions recently. Ross River virus (RRV) is endemic in Australia and has epidemic potential. In Malaysia, Aedes mosquitoes are abundant and drive dengue and chikungunya outbreaks. We assessed risk of an RRV outbreak in Kuala Lumpur, Malaysia by determining vector competence of local Aedes mosquitoes and local seroprevalence as a proxy of human population susceptibility.

Methodology/Principal findings
We assessed oral susceptibility of Malaysian Ae. aegypti and Ae. albopictus by real-time PCR to an Australian RRV strain SW2089. Replication kinetics in midgut, head and saliva were determined at 3 and 10 days post-infection (dpi). With a 3 log10 PFU/ml blood meal, infection rate was higher in Ae. albopictus (60%) than Ae. aegypti (15%; p<0.05). Despite similar infection rates at 5 and 7 log10 PFU/ml blood meals, Ae. albopictus had significantly higher viral loads and required a significantly lower median oral infectious dose (2.7 log10 PFU/ml) than Ae. aegypti (4.2 log10 PFU/ml). Ae. albopictus showed higher vector competence, with higher viral loads in heads and saliva, and higher transmission rate (RRV present in saliva) of 100% at 10 dpi, than Ae. aegypti (41%). Ae. aegypti demonstrated greater barriers at either midgut escape or salivary gland infection, and salivary gland escape. We then assessed seropositivity against RRV among 240 Kuala Lumpur inpatients using plaque reduction neutralization, and found a low rate of 0.8%.

Conclusions/Significance
Both Ae. aegypti and Ae. albopictus are susceptible to RRV, but Ae. albopictus displays greater vector competence. Extensive travel links with Australia, abundant Aedes vectors, and low population immunity places Kuala Lumpur, Malaysia at risk of an imported RRV outbreak. Surveillance and increased diagnostic awareness and capacity are imperative to prevent establishment of new arboviruses in Malaysia.
Experiences and preferences for advance care planning following a diagnosis of dementia: Findings from a cross-sectional survey of carers
Authors: Bryant Jamie , Mansfield Elise , Cameron Emilie , Sanson-Fisher Rob 
Published: June 2023

Background
Future medical and financial planning is important for persons with dementia given the impact of the disease on capacity for decision making.

Aims
To explore from the perspective of carers of persons with dementia: (1) Participation in future medical and financial planning by the person they care for, including when planning was undertaken and the characteristics associated with having an advance care directive completed; (2) The type of healthcare providers who discussed advance care planning following diagnosis; and (3) Preferences for timing of discussions about advance care planning following diagnosis.

Methods
Recruitment and data collection took place between July 2018 and June 2020. Carers of persons with dementia aged 18 years and older were mailed a survey. Participants completed questions regarding completion of various future planning documents by the person they support, including time of completion and who discussed advance care planning following diagnosis. Participants were presented with information about the benefits and consequences of early and late discussions of advance care planning and asked when discussions about advance care planning were best initiated.

Results
198 carers participated. Most participants were female (74%) and had been a carer for more than 2 years (82%). Most participants reported that the person with dementia they support had made a Will (97%) and appointed an Enduring Guardian (93%) and Enduring Power of Attorney (89%). Only 47% had completed an advance care directive. No significant associations were found between characteristics of persons with dementia and completion of an advance care directive. Geriatricians (53%) and GPs (51%) most often discussed advance care planning following diagnosis. Most carers thought that discussions about advance care planning should occur in the first few weeks or months following diagnosis (32%), at the healthcare provider’s discretion (31%), or at the time of diagnosis (25%).

Conclusions
More than half of persons with dementia do not have an advance care directive. There is variability in preferences for timing of discussions following dementia diagnosis.
Reporting on Sexual Violence in the #MeToo Era, Andrea Baker and Usha Manchanda Rodrigues (eds) (2022)
Authors: Gleave Josie 
Published: June 2023

Review of: Reporting on Sexual Violence in the #MeToo Era, Andrea Baker and Usha Manchanda Rodrigues (eds) (2022)
London: Taylor & Francis Group, 224 pp.,
ISBN 978-1-03211-552-8, h/bk, USD 252
ISBN 978-1-00322-041-1, p/bk, USD 73.99
ISBN 978-1-00077-104-6, e-book, USD 60.29
Mise en scène, Acting, and Space in Comics, Geraint D’Arcy (2020)
Authors: Nagtegaal Jennifer 
Published: June 2023

Review of: Mise en scène, Acting, and Space in Comics, Geraint D’Arcy (2020)
Cham: Nature Switzerland AG, 136 pp.,
ISBN 978-3-03051-113-5, p/bk, $69.99
Association of Alanine Aminotransferase Flares to Hepatitis B Surface Decline During Tenofovir Alone or With Pegylated Interferon Alfa
Authors: Perrillo Robert , Lok Anna S. , Leonard Kelsey , Ghany Marc G. , Terrault Norah , Belle Steven H. , Janssen Harry L.A. ,   for the Hepatitis B Research Network
Published: June 2023

INTRODUCTION:
We aimed to determine whether the intensity of alanine aminotransferase (ALT) flares during antiviral therapy is associated with the level of hepatitis B surface antigen (HBsAg) decline.

METHODS:
Quantitative HBsAg was determined during tenofovir monotherapy or tenofovir plus peginterferon alfa-2a in 201 participants with hepatitis B e antigen–positive or –negative chronic hepatitis B. A multivariable analysis identified factors associated with a shorter time to reduction in HBsAg.

RESULTS:
Fifty flares occurred during treatment of which 74% were moderate (ALT >5–10 × upper limit of normal) or severe (ALT >10 × upper limit of normal). These flares were associated with greater HBsAg decline compared with no flares. Significantly faster times to HBsAg decline >1 log10 IU (P = 0.04) and to HBsAg level <100 IU/mL (P = 0.01) were observed with severe flares.

DISCUSSIONS:
Flare severity is a potentially important factor associated with shorter time to HBsAg reduction. These findings can be useful when evaluating HBsAg response to evolving hepatitis B virus therapies.
Immune Checkpoint Inhibitors Suppress Hepatitis C Virus Replication in Infected Patients With Solid Tumors
Authors: Yibirin Marcel , Mustafayev Khalis , Hosry Jeff , Pundhir Pooja , Klingen Joseph , Yepez Guevara Eduardo , Granwehr Bruno P. , Kaseb Ahmed , Naing Aung , Patel Sapna , Shah Amishi Y. , Skoulidis Ferdinandos , Tawbi Hussein A. , Wang Lan , Miller Ethan , Zhang Hao Chi , Zurita-Saavedra Amado , Torres Harrys A. 
Published: June 2023

INTRODUCTION:
Data are scarce regarding the virologic impact and safety of immune checkpoint inhibitors (ICI) in patients with chronic hepatitis C virus (HCV) infection. We examined the virologic impact of ICI in HCV-infected patients with solid tumors and their safety.

METHODS:
HCV-infected patients with solid tumor treated with ICI at our institution between April 26, 2016, and January 5, 2022, were enrolled in a prospective observational study. The primary outcomes were ICI-induced changes in HCV viremia (HCV inhibition and HCV reactivation) and safety of ICI.

RESULTS:
We enrolled 52 consecutive patients with solid tumors treated with ICI. Most were men (41; 79%), White (31; 59%), without cirrhosis (34; 65%), and with HCV genotype 1 (40; 77%). Four patients (7.7%) experienced HCV inhibition while receiving ICI including 1 patient who developed undetectable viremia for 6 months in the absence of direct-acting antivirals (DAA). Two patients (4%) developed HCV reactivation, both while receiving immunosuppressive therapy for ICI-related toxic effects. Adverse events occurred in 36 patients (69%), and 39 of the 47 adverse events (83%) were grade 1–2. Grade 3–4 adverse events occurred in 8 patients (15%), and in all cases, they were related to ICI, not to HCV. No HCV-associated liver failure or death occurred.

DISCUSSION:
Inhibition of HCV replication with virologic cure can develop in patients receiving ICI without DAA. HCV reactivation occurs primarily in patients receiving immunosuppressants for ICI-related toxic effects. ICI are safe in HCV-infected patients with solid tumors. Chronic HCV infection should not be considered a contraindication for ICI therapy.
Implementation of the EVRF2007 height reference frame in Poland
Authors: Borowski Łukasz , Kubicki Bartosz , Gołąb Janusz 
Published: June 2023

Abstract
Currently, in Poland, the State Spatial Reference System (SSRS) includes two height reference frames: PL-KRON86-NH and PL-EVRF2007-NH as the Polish implementation of the European Vertical Reference System (EVRF). The deadline for EVRF2007 implementation in Poland, as the only legally permitted height frame, is set at the end of 2023. Because of the administrative division, the implementation was planned in two stages: at the state level (government) and the local level (districts). In the article, the local ones are reviewed, especially regarding the aim of height conversion methods, costs and their progress. As a background, a historical perspective of height systems and frames used in Poland since the beginning of the 20th century is provided. The source of data was the Head Office of Geodesy and Cartography (HOGC), as well as the district surveying departments’ official answers; open documents posted on the Internet, e.g. tender documentation and their results were also analysed.
Crisis as Opportunities for Robust Government: A Systematic Review of Policy Process Literature
Authors: Zhang Manli , Crow Deserai A. , Dai Shihao , Ma Ben 
Published: June 2023

Abstract
Increasing risks and crises present a challenging new normal for contemporary emergency management. It is important for public organizations to build robust government structures that can adapt to changing circumstances, rather than conform to rigid established procedures. Nevertheless, scholars have not fully explored how the transition to such robustness develops after crisis events. This paper fills the research gap by proposing an event-driven policy process model based on 171 identified crisis event studies, whereby a crisis drives learning that leads to changes in government structures or policy processes. Using a systematic review of the literature, we find that variation in crisis type and scale of impact influence subsequent policy dynamics that are critical to learning by governments. Key process dynamics (e.g. agenda setting, policy formulation, and implementation) and various types of learning are identified in the crisis-driven process that leads to robustness in public organizations. In addition, the role of scientific evidence and learning decay also play roles in this transition.
Neuropathy in paediatric type 1 diabetes mellitus – clinical characterization and analysis of risk factors in the diabetes prospective follow-up registry DPV (Diabetes-Patienten-Verlaufsdokumentation)-registry
Authors: Pappa Angeliki , Haeusler Martin G. , Tittel Sascha R. , Boettcher Claudia , Hilgard Doerte , Knauer-Fischer Sabine , Pavel Marianne , Woelfle Joachim , Holl Reinhard W. 
Published: June 2023

Abstract

Objectives
Data on the prevalence, clinical features and risk factors associated with paediatric diabetic neuropathy (DN) are scarce.

Methods
We retrospectively analysed data from the DPV registry, including patients under 20 years of age, treated for type 1 diabetes mellitus (T1D) between 2005 and 2021. Patients with non-diabetic neuropathy were excluded. Data came from centres in Austria, Germany, Luxembourg and Switzerland.

Results
1,121 of the 84,390 patients included had been diagnosed with DN. Univariate analysis showed patients with DN to be older and predominantly female, with a longer duration of T1D, higher insulin dosages per kg and day, lower rates of insulin pump therapy, higher postprandial glucose-, higher HbA1c-and higher cholesterol levels, and higher diastolic and systolic blood pressure values. There was also a larger proportion of smokers and higher prevalence of diabetic retinopathy. Median duration of diabetes at diagnosis of DN was 8.3 years. Multivariable analysis, adjusted for demographics revealed an increased risk for DN among female patients and those who were older, underweight (BMI-SDS), smoked cigarettes or had a longer duration of T1D or higher levels of HbA1c and postprandial blood glucose. The presence of retinopathy and higher cholesterol levels were also linked to increased risk while not-using insulin pump therapy was not.

Conclusions
DN can develop after just a short duration of T1D. Prevention may be achieved by a lowering of HbA1c-and postprandial glucose levels through improved glycaemic control. This warrants further investigation. The slight female predominance suggests further hormonal and genetic etiological factors.
Quality assurance within the context of genome diagnostics (a german perspective)
Authors: Florian Kraft , Benet-Pagès Anna , Berner Daniel , Teubert Anna , Eck Sebastian , Arnold Norbert , Bauer Peter , Begemann Matthias , Sturm Marc , Kleinle Stephanie , B. Haack Tobias , Eggermann Thomas 
Published: June 2023

Abstract
The rapid and dynamic implementation of Next-Generation Sequencing (NGS)-based assays has revolutionized genetic testing, and in the near future, nearly all molecular alterations of the human genome will be diagnosable via massive parallel sequencing. While this progress will further corroborate the central role of human genetics in the multidisciplinary management of patients with genetic disorders, it must be accompanied by quality assurance measures in order to allow the safe and optimal use of knowledge ascertained from genome diagnostics. To achieve this, several valuable tools and guidelines have been developed to support the quality of genome diagnostics. In this paper, authors with experience in diverse aspects of genomic analysis summarize the current status of quality assurance in genome diagnostics, with the aim of facilitating further standardization and quality improvement in one of the core competencies of the field.
Grand strategy of politeness in new social networks: revisiting Leech’s politeness theory among Iranian EFL learners using Telegram
Authors: Ahmadi Reza , Weisi Hiwa 
Published: June 2023

Abstract
Human beings utilize varied linguistic politeness to facilitate interaction and minimize the potential for conflict. With the advancement of the Computer-Mediated Communication (CMC) and the introduction of new social networks, studying how politeness operates within human communication opened up new avenues for research, particularly within diverse cultures. For this reason, the current study sought to report on the “whats” and “hows” of politeness strategies identified in Telegram messages delivered by EFL Learners in Iran. Data were analyzed based on Leech’s (Leech, Geoffrey. 2007. Politeness: Is there an East-West divide? Journal of Politeness Research 3(2). 167–206) Grand Strategy of Politeness, considering the purpose of communication, politeness strategies, and context. The corpus for this study encompassed 1,413 text messages sent via Telegram by 9 EFL learners during one year. Findings indicated a number of different politeness strategies in Iranian culture, specifically the modesty constraint – the speaker maximizes dispraise of himself – which can be construed as one of the unique features and influences of Islamic teachings. Moreover, the Leech’s model might appropriately describe politeness principles in Asian contexts, including Iran, and how cultural dynamics manifest themselves in interpreting the concept of politeness.
Spencer-Brown, Luhmann and Klein on Symmetry
Authors: Guy Jean-Sébastien 
Published: June 2023

Abstract
This article discusses the concept of symmetry as Felix Klein developed it in his works on geometry as a measure of invariance. The objective is to generalize from Klein’s model and principles to be able to apply the concept of symmetry to the study of social structures or social formations in sociology. To achieve this goal, the article goes on to consider how the concept of symmetry bears on the Laws of Form of George Spencer-Brown and on Niklas Luhmann’s theory of functional differentiation. Both of them are reinterpreted in terms of symmetry breaking.
Distinction Dynamics: A Form Analysis of Self-Descriptions in Agile Teams
Authors: Grote Florian 
Published: June 2023

Abstract
Teams are the backbone and the most successful form of cooperation in contemporary product development organizations. Based on the agile mindset, many best practices of team organization have emerged. However, real teams do not always follow the blueprints of the methodology. They represent the complexity they face, which becomes evident in a situation where a global pandemic brings about dramatic changes in the contexts they operate in. This study is based on consultations with teams that sought outside support maneuvering their way through this complexity, and it looks for patterns in how they coped. How do teams describe their own journey? How do they set a focus and develop as teams? The study aims to identify and describe functional dynamics of decision-making in teams, to understand how structure and semantics, traditionally seen as separate, are interrelated in their morphogenesis.
Real-time vignetting compensation and exposure correction for panoramic images by optimizing irradiance consistency
Authors: Kinzig Christian , Feng Guanzhi , Granero Miguel , Stiller Christoph 
Published: June 2023

Abstract
Image-based object detection is a crucial task in autonomous driving. In many cases, objects are not correctly detected and classified if they are only partially visible due to a limited field of view. Also, even if stitched panoramic images are used, errors in object detection can still occur if the seam between individual images is visible. This happens due to vignetting or different exposure, although the images are optimally aligned. In this article, we present a real-time capable and effective method for vignetting compensation and exposure correction. Before runtime, the camera response function is determined and the vignetting model is preliminarily approximated. We obtain the irradiance from the intensity values of incoming images. Then, the vignetting model is applied. Afterwards, the pixels at the seam are used to correct the exposure. Finally, we convert the corrected irradiance back to intensity values. We evaluate our approach by measuring the image stitching accuracy in the overlapping area by the IoU of grayscale histograms and the mean absolute error of intensity values. The metrics are applied both on data recorded with our experimental vehicle and on the publicly available nuScenes dataset. Finally, we demonstrate that our approach runs in real-time on GPU.