bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syringaresinol inhibits cardiorenal fibrosis through HSP90 in a cardiorenal syndrome type 2
Authors: Wang Jianjie , Zou Jianqin , Zhao Cheng , Yu Han , Teng Jiajia , Dong Lei 
Published: March 2023

Background Syringaresinol processes anti-inflammatory and antioxidative activity. However, the effects of syringaresinol on cardiorenal fibrosis caused by cardiorenal syndrome type 2 (CRS2) are unclear. Methods Molecular docking predicted binding activity of syringaresinol to heat shock protein 90 (HSP90). The toxicity of a 4-weeks treatment with 20 mg/kg of syringaresinol was observed by measuring serum pro-inflammatory cytokines levels and by cardiorenal pathology. A CRS2 rad model was established by myocardial infarction using ligation over an 8 week-period. Rats were divided into five groups, including sham, CRS2, pimitespib, syringaresinol, and HSP90 + syringaresinol. Rats were received a 4-weeks daily treatment with 10 mg/kg pimitespib (a HSP90 inhibitor) or 20 mg/kg syringaresinol. Recombinant adeno-associated virus (rAAV) carrying a periostin (PE) promoter driving the expression of wild-type HSP90 (rAAV9-PE-HSP90, 1 × 1011 μg) was treated intravenously once in CRS2 model rats. Cardiorenal function and pathology were assessed. Expressions of HSP90 and TGF-β1 in the myocardium and kidney were measured by immunohistochemistry and western blotting. Results Syringaresinol showed good binding activity with HSP90, and no signs of toxicity in rats following treatment. Pimitespib or syringaresinol significantly improved the cardiorenal function and fibrosis in rats with CRS2. Meanwhile, the rAAV9-PE-HSP90 injection obviously blocked the effects of syringaresinol. Conclusions Syringaresinol targets HSP90 to suppress CRS2-induced cardiorenal fibrosis, providing a promising therapeutic drug for CRS2.
Simulated Weightbearing Fluoroscopy to Assess Intraoperative Hindfoot Alignment
Authors: Li Ying , Li Wenjing , Sun Ning , Zhang Baozhou , Wu Yong 
Published: March 2023

Background: Intraoperative evaluation of hindfoot alignment is one of the factors that may affect outcomes for foot and ankle reconstructive surgery. The present study was performed to evaluate the effect of simulated weightbearing fluoroscopy on the intraoperative assessment of hindfoot alignment reconstruction. Methods: The medical records of patients diagnosed with disorders of the foot and ankle with abnormal hindfoot alignment were retrospectively reviewed from November 2014 to November 2021. Hindfoot alignment view (HAV) fluoroscopy in the simulated weightbearing position and HAV radiographs were routinely recorded during and after surgery, respectively. The hindfoot alignment angle (HAA) and hindfoot alignment ratio (HAR) were measured on intraoperative and postoperative images, respectively. Results: Seventy-two women and 82 men (155 ankles) with a mean age of 45.48 years were included in the present study. The intraobserver and interobserver reliabilities of the HAA and HAR measurements were satisfactory. The intraoperative and postoperative HAA was −0.7 ± 4.8 degrees and −0.2 ± 5.0 degrees, respectively. The mean HAR on intraoperative fluoroscopy and postoperative radiographs was 37.4% ± 19.7% and 40.4% ± 18.2%, respectively. Simple regression analysis revealed a correlation between the intraoperative and postoperative HAA ( R2 = 0.631, P < .001) and HAR ( R2 = 0.262, P < .001). Univariate analysis suggested that the difference between the intraoperative and postoperative HAA was positively affected by the body mass index ( P < .001). Conclusion: The present study showed that intraoperative HAV fluoroscopy in the simulated weightbearing position is a potentially useful method to predict postoperative hindfoot alignment in the weightbearing position. Patients with a lower body mass index had smaller HAA deviations between intraoperative and postoperative measurements of hindfoot alignment. Level of Evidence: Level IV, retrospective case series.
Design and characterization of reversible thermodynamic SMPU-based fabrics with improved comfort properties
Authors: Gonzalez Bertran Judit , Ardanuy Mònica , González Marta , Rodriguez Rosa , Jovančić Petar 
Published: March 2023

In recent years, great efforts have been made to research and develop advanced thermodynamic textiles that can change their thermal behavior in response to external stimuli. More specifically, shape memory alloys and shape memory polymer coatings have used for thermal comfort applications. However, the use of shape memory polymers in the form of filament yarns integrated in the fabrics has not yet reported. These fabrics have some advantages related to versatility in shape design. The aim of this study was to develop woven SMPU-based fabrics with reversible thermodynamic properties induced by weft SMPU filament yarns interlaced into polyester (PES) fabrics. To this end, PES woven fabrics with different ratios of weft SMPU filament yarns (PES/SMPU 1:0; 3:1; 1:1; 1:3, and 0:1) were developed and their thermodynamic properties (thermal resistance, water vapor resistance, and permeability index), shape memory effect, and mechanical performance were evaluated and compared to the 100% PES reference fabric. All the SMPU-based fabrics developed were classified as extremely breathable (water vapor resistance <6 m2·Pa/W) and thermally comfortable (water vapor permeability index <0.3). The fabrics integrating the SMPU filament yarns reacted dynamically to the temperature stimuli over and below Tg, whereas the 100% PES fabric showed passive thermodynamic behavior. This dynamism led to an improvement in thermal protection against an increase in ambient temperature, reaching values of 13.18 mK·m2/W in thermal resistance (PES/SMPU 0:1), while also maintaining good moisture management properties, reaching values of 5.19 m2·Pa/W in water vapor resistance (PES/SMPU 0:1).
Mindfulness Using a Wearable Brain Sensing Device for Health Care Professionals During a Pandemic: A Pilot Program
Authors: Ghosh Karthik , Nanda Sanjeev , Hurt Ryan T. , Schroeder Darrell R. , West Colin P. , Fischer Karen M. , Bauer Brent A. , Fokken Shawn C. , Ganesh Ravindra , Hanson Jennifer L. , Lindeen Stephanie A. , Pruthi Sandhya , Croghan Ivana T. 
Published: March 2023

Objective: The purpose of this feasibility pilot study was to evaluate safety and adherence of a wearable brain sensing wellness device designed to reduce stress among healthcare professionals (HCP). Methods: A total of 40 HCP were invited to participate in an open-label pilot study. Participants were asked to use a brain sensing wearable device (MUSE-S™) on a daily basis to reduce their stress, for a total of 90 days. Total study participation duration was 180 days. Study enrollment began in August 2021 and ended December 2021. The exploratory outcomes included stress, depression, sleep, burn-out, resilience, quality of life, and cognition. Results: Among the 40 HCP in study, the majority were female (85%), white (87.5%) and with an average age of 41.3 ± 11.0 years (SD). Participants used the wearable device an average of 23.8 times over a 30-day period with a mean duration of 5.8 min with each use. Study results demonstrate the positive impact of guided mindfulness using the wearable device MUSE-S™ and its accompanying application (APP). A statistically significant improvement was found for a reduction in stress ( P < .001) and improvement in resilience ( P = .02), quality of life ( P = .003), and cognition ( P < .001). The majority (91.9%) of the participants indicated they felt more relaxed after using the device, and 73% indicated they would continue to use this device at end-of-study. No adverse effects were reported. Conclusion: Study results show that 3 to 10 min of guided meditation during work hours through the use of a brain sensing wearable device is safe and acceptable, with associated health benefits for HCP.
Prevalence of chronic periodontitis in patients undergoing peritoneal dialysis and its correlation with peritoneal dialysis-related complications
Authors: Chen Zhihao , Deng Hai , Sun Kristine , Huang Zehui , Wei Shan , Lin Yunyao , Song Zhongchen , Liu Yingli 
Published: March 2023

AbstractObjectiveThe microinflammatory state can influence the occurrence of dialysis-related complications in dialysis patients. Chronic periodontitis (CP), in which plaque biofilm is considered to be the initiating factor, is a chronic infectious disease in the oral cavity. It is still uncertain whether CP affects the microinflammatory state in peritoneal dialysis (PD) and the occurrence of dialysis-related complications. The purpose of this study was to investigate the correlation between the periodontal index and clinical parameters in peritoneal dialysis patients with CP and dialysis-related complications, including peritoneal dialysis-associated peritonitis (PDAP) and cardiovascular and cerebrovascular events (CCEs).MethodsThis was a retrospective cohort study, and 76 patients undergoing PD were enrolled. Clinical parameters, the occurrence of PD-related complications and periodontitis-related indicators, including the gingival index (GI), plaque index (PLI), probing depth (PPD) and clinical attachment loss (CAL), were collected. Correlation analysis was used to explore the correlation between periodontal or clinical parameters and the occurrence of PD-related complications.ResultsAll the patients had different degrees of periodontitis (mild 9.2%, moderate 72.4%, severe 18.4%); PPD was inversely related to serum albumin (r = − 0.235,p = 0.041); CAL has a positive correlation with serum C-reactive protein (rs = 0.242,p = 0.035); PLI was positively correlated with serum calcium (r = 0.314,p = 0.006). ANOVA, multivariate logistic regression analysis and Kaplan-Meier Survival curve suggested that CAL was a risk factor for the occurrence of PDAP. There was no correlation between periodontal parameters and CCEs or poor prognosis.ConclusionCP is universally present in PD patients, and the presentation of periodontitis influences the systemic inflammatory state in PD patients. CP is a risk factor for PDAP.
Nursing in oncology ward with intertwined roles: a focused ethnography
Authors: Ziarat Hadiseh Monadi , Seyedfatemi Naima , Mardani-Hamooleh Marjan , Farahani Mansoureh Ashghali , Vedadhir AbouAli 
Published: March 2023

Abstract
Background
Characteristics of nursing care in the oncology ward depend on this ward’s specific context. This study aimed to investigate the nursing care in the oncology ward regarding the culture of this ward.

Methods
This qualitative study was conducted in an oncology ward using a focused ethnographic approach. The whole nursing team of the selected ward (N = 16) participated in the study through purposeful sampling. Three methods of observation, interview, and field documents were used for data collection. Data were analyzed by Spradley’s (1980) ethnographic method.

Results
‘Nursing in the oncology ward with intertwined roles’ emerged as the main theme. This theme included the following subthemes: ‘Robin Hood nurse,’ ‘a secretive nurse,’ ‘a negligent nurse,’ ‘a snitching nurse,’ ‘a complaining nurse,’ ‘an apathetic senior nurse,’ ‘a stigmatized training nurse,’ ‘a brazen-bodied nurse,’ ‘a compassionate nurse,’ ‘a moonlighting nurse,’ and ‘a drug bartender.’

Conclusion
This study provided a deep cultural insight into nursing care in the oncology ward, considering the particular culture of this ward and emphasizing the nurses’ intertwined roles. These roles are on a spectrum, with positive roles, such as compassion, on one side and negative roles, such as negligence, on the other. The results of this study can be provided to nursing managers; therefore, by being aware of nurses’ roles considering the specific subculture of the oncology ward, they can provide psychological interventions to improve the mental health of reluctant and complaining nurses and ethics-based training for secretive, negligent, and snitching nurses to provide quality care to the patient.
Inhibition of miR-4640-5p alleviates pulmonary hypertension in chronic obstructive pulmonary disease patients by regulating nitric oxide synthase 1
Authors: Yang Zhao , Li Ping , Yuan Qun , Wang Xi , Ma Hong-Hong , Zhuan Bing 
Published: March 2023

Abstract
Background
Pulmonary hypertension (PH) is a devastating disease characterized by vasoconstriction and vascular remodeling, leading to right ventricular failure and death. PH is a common complication of chronic obstructive pulmonary disease (COPD). Accumulating evidence demonstrate that microRNAs participate in the pathobiology of PH in COPD patients. In this study, we aimed to evaluate the expression and function of microRNA-4640-5p (miR-4640-5p) in PH.

Methods
The mRNA and protein levels were determined by quantitative polymerase chain reaction (qPCR) and western blot, separately. Functional assays and western blot were performed to determine the effects of miR-4640-5p and NOS1 on cell growth, migration. Besides, the dual-luciferase reporter assays were used to validate miR-4640-5p and NOS1 interactions.

Results
We found that miR-4640-5p expression was significantly higher in the lung tissues of COPD-PH patients than in the healthy controls while higher expression of miR-4640-5p was correlated with more severe COPD-PH. By using pulmonary artery smooth muscle cell (PASMC) in in vitro assays, we demonstrated that inhibition of miR-4640-5p suppressed cell proliferation and migration of PASMC via regulating mTOR/S6 signaling. Bioinformatics analysis and validation experiments revealed that nitric oxide synthase 1 (NOS1) was a direct downstream target of miR-4640-5p. Overexpression of NOS1 partially antagonized the effect of miR-4640-5p in regulating PASMC cell proliferation and migration. In addition, our findings suggested that miR-4640-5p/NOS1 axis regulated mitochondrial dynamics in PASMCs. Furthermore, in the hypoxia-induced PH rat model, inhibition of miR-4640-5p ameliorated PH with reduced right ventricular systolic pressure and Fulton index.

Conclusions
miR-4640-5p regulates PH via targeting NOS1, which provides a potential diagnostic biomarker and therapeutic target for COPD-PH patients.
Intense solar activity reduces urinary 6-sulfatoxymelatonin in patients with COPD
Authors: Zilli Vieira Carolina L. , Koutrakis Petros , Liu Man , Gottlieb Daniel J. , Garshick Eric 
Published: March 2023

Abstract
Background
Little is known about the link between solar activity and variations in melatonin. In this study, we investigated if melatonin's major urinary metabolite, urinary 6-sulfatoxymelatonin (aMT6s), is lowest under periods of intense solar activity.

Methods
We investigated associations between high-energy solar particle events [Coronal Mass Ejection (CME) mass, speed and energy] on creatinine-adjusted aMT6s (aMT6sr) concentrations in 140 patients with chronic obstructive pulmonary disease (COPD) using up to four seasonal urine samples (n = 440). Mixed effect models with a random intercept for each subject were used to estimate associations, including effect modification attributable to diabetes, obesity, and reduced pulmonary function.

Results
Higher values of CME were associated with reduced aMT6sr concentrations, with stronger associations in patients with diabetes. An interquartile range (IQR) increase in natural log CMEspeed averaged through two days before urine collection was associated with a reduction of 9.3% aMT6sr (95%CI: − 17.1%, − 0.8%) in aMT6sr. There was a greater reduction in aMT6sr in patients with diabetes (− 24.5%; 95%CI: − 35.9%, − 11.6%). In patients without diabetes there was no meaningful association (− 2.2%; 95%CI: − 12%, 8.4%). There were similar associations with CMEenergy and CMEmass. There was no effect modification attributable to reduced pulmonary function or obesity.

Conclusions
This is the first study in patients with COPD to demonstrate strong detrimental impact of high-energy solar particle events on aMT6sr, with greater associations in patients with diabetes. Since melatonin is an anti-oxidant, it is possible that adverse effects of intense solar activity may be attributable to a reduction in circulating melatonin and that patients with both COPD and diabetes may be more susceptible.
Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC
Authors: Venkateswaran Suresh , Somineni Hari K. , Matthews Jason D. , Kilaru Varun , Hyams Jeffrey S. , Denson Lee A. , Kellamayer Richard , Gibson Greg , Cutler David J. , Conneely Karen N. , Smith Alicia K. , Kugathasan Subra 
Published: March 2023

Abstract
Background
In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) patients, focusing on constituent cell types with the goal of identifying therapeutic targets for UC other than the immune system. We profiled DNAm of rectal mucosal biopsies of pediatric UC at diagnosis (n = 211) and non-IBD control (n = 85) patients and performed epigenome-wide association studies (EWAS) of specific cell types to understand DNAm changes in epithelial, immune and fibroblast cells across disease states, course, and clinical outcomes. We also examined longitudinal analysis on follow-up samples (n = 73), and comparisons were made among patients with clinical outcomes including those undergoing colectomy versus those who did not. Additionally, we included RNA-seq from the same subjects to assess the impact of CpG sites on the transcription of nearby genes during the disease course.

Results
At diagnosis, UC rectal mucosa exhibited a lower proportion of epithelial cells and fibroblasts, and higher proportion of immune cells, in conjunction with variation in the DNAm pattern. While treatment had significant effects on the methylation signature of immune cells, its effects on fibroblasts and epithelial cells were attenuated. Individuals who required colectomy exhibited cell composition and DNAm patterns at follow-up more similar to disease onset than patients who did not require colectomy. Combining these results with gene expression profiles, we identify CpG sites whose methylation patterns are most consistent with a contribution to poor disease outcomes and could thus be potential therapeutic targets.

Conclusions
Cell-specific epigenetic changes in the rectal mucosa in UC are associated with disease severity and outcome. Current therapeutics may more effectively target the immune than the epithelial and fibroblast compartments.

Graphical abstract
Cultivating EFL learners’ productive skills by employing dynamic and non-dynamic assessments: attitude in focus
Authors: Riswanto  , Teferi Habesha , Ahmed Abdel-Al Ibrahim Khaled 
Published: March 2023

AbstractIn this study, the potential impacts of dynamic assessment (DA) and non-dynamic assessment (non-DA) on Ethiopian EFL students’ productive skills were investigated. Additionally, this study examined Ethiopian EFL students’ attitudes regarding using DA in their speaking and writing classes. Fifty-three Ethiopian intermediate EFL learners were selected using the convenience sampling method and separated into two groups in order to accomplish these goals. Next, both groups were pretested on two skills of writing and speaking. Then, one group received speaking and writing instruction utilizing DA, whereas the other group received instruction using non-DA. After 16 sessions of training, the groups received writing and speaking posttests, and the DA group also received an attitude questionnaire. The results indicated that there was a significant difference between the speaking and writing posttests of both groups in favor of the experimental group. In fact, the study’s findings revealed that the DA group outstripped the non-DA group on the speaking and writing posttests. The outcomes also indicated that the participants of the DA group held positive attitudes toward the AD. It was concluded that using the DA in EFL classes is an effective method for advancing EFL students’ English language acquisition. The implications of this research can persuade teachers to apply DA in their teaching process.
State of conservation analysis of the Elliptical Wall of the Temple of the Sun in Ingapirca (Ecuador) and its relationship with climate conditions
Authors: Aguirre Ullauri María del Cisne , Torres-Quezada Jefferson , López Suscal Michelle 
Published: March 2023

Abstract
The conservation of cultural heritage in Ecuador is an increasingly complex task, evident for several centuries in the Ingapirca Archaeological Complex and particularly in the Elliptical Wall of the Temple of the Sun. Given the weathering, intensified by its geographic location, this monument presents a high level of deterioration despite much previous research and the execution of conservation actions. Therefore, this research proposes a comprehensive study that relates the deterioration processes of the Elliptical Wall and the climate conditions where it is located. The method of wall stratigraphic reading has been used, complemented by an analysis of condensation and solar gain. The results show that the building comprises nine phases, four in common for all the orientations from 700 AD, which define the property's authenticity, and five characterized by diverse interventions. At least 38 construction, reconstruction, and maintenance activities have been identified in 9 historical-construction phases and ten degradation phases. In addition, all the orientations of the Elliptical Wall reach the dew point at night, given the relative humidity and air temperature levels in the study region. The southern orientation stands out as the surface with the highest frequency of condensation, the lowest solar gain, and the highest percentage of affections. Thus, this study supports that the deterioration of this building has a high correlation with its condensation capacity, which intensifies or reduces depending on the levels of solar capture; the monument will continue to be transformed and even eliminate historic strata due to the irreversible deterioration in different sectors and the current difficulties in mitigating it.
Demurrage and detention: from operational challenges towards solutions
Authors: Storms Katrien , Sys Christa , Vanelslander Thierry , Van Deuren Ruben 
Published: March 2023

AbstractReduced free time and increased fees for demurrage and detention create organizational challenges with respect to intermodal transport. As a result, actors within the maritime supply chains are confronted with greater complexity and higher risk of costs; and, therefore, often fall back on transportation by truck to and from the hinterland. That is why the present research examines the impact of this evolution on the bottom line of the involved actors from a maritime supply chain perspective. The research approach consists of reviewing the relevant literature, analyzing the available sector data obtained through interviews and professional experience, and validating the proposed solutions. Starting from the research results, the problem-solving discussions resulted in the following top three as feasible solutions: digitalization, extra ‘free time’ for hinterland locations, and more attention during the negotiation process.