bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systems genetics identifies miRNA-mediated regulation of host response in COVID-19
Authors: Gjorgjieva T. , Chaloemtoem A. , Shahin T. , Bayaraa O. , Dieng M. M. , Alshaikh M. , Abdalbaqi M. , Del Monte J. , Begum G. , Leonor C. , Manikandan V. , Drou N. , Arshad M. , Arnoux M. , Kumar N. , Jabari A. , Abdulle A. , ElGhazali G. , Ali R. , Shaheen S. Y. , Abdalla J. , Piano F. , Gunsalus K. C. , Daggag H. , Al Nahdi H. , Abuzeid H. , Idaghdour Y. 
Published: June 2023

Abstract
Background
Individuals infected with SARS-CoV-2 vary greatly in their disease severity, ranging from asymptomatic infection to severe disease. The regulation of gene expression is an important mechanism in the host immune response and can modulate the outcome of the disease. miRNAs play important roles in post-transcriptional regulation with consequences on downstream molecular and cellular host immune response processes. The nature and magnitude of miRNA perturbations associated with blood phenotypes and intensive care unit (ICU) admission in COVID-19 are poorly understood.

Results
We combined multi-omics profiling—genotyping, miRNA and RNA expression, measured at the time of hospital admission soon after the onset of COVID-19 symptoms—with phenotypes from electronic health records to understand how miRNA expression contributes to variation in disease severity in a diverse cohort of 259 unvaccinated patients in Abu Dhabi, United Arab Emirates. We analyzed 62 clinical variables and expression levels of 632 miRNAs measured at admission and identified 97 miRNAs associated with 8 blood phenotypes significantly associated with later ICU admission. Integrative miRNA-mRNA cross-correlation analysis identified multiple miRNA-mRNA-blood endophenotype associations and revealed the effect of miR-143-3p on neutrophil count mediated by the expression of its target gene BCL2. We report 168 significant cis-miRNA expression quantitative trait loci, 57 of which implicate miRNAs associated with either ICU admission or a blood endophenotype.

Conclusions
This systems genetics study has given rise to a genomic picture of the architecture of whole blood miRNAs in unvaccinated COVID-19 patients and pinpoints post-transcriptional regulation as a potential mechanism that impacts blood traits underlying COVID-19 severity. The results also highlight the impact of host genetic regulatory control of miRNA expression in early stages of COVID-19 disease.
Numerical modelling of the process chain for aluminium Tailored Heat-Treated Profiles
Authors: Fröck Hannes , Graser Matthias , Reich Michael , Lechner Michael , Merklein Marion , Kessler Olaf 
Published: June 2023

AbstractLightweight construction in modern car design leads to an increased usage of various aluminium semi-finished products. Besides sheet material, aluminium extrusion profiles are frequently used due to their high stiffness and variety of possible cross-sections. However, similar to sheet material, aluminium profiles exhibit limited formability in comparison to mild steel materials. One possibility to increase the forming limits of precipitation hardened aluminium alloys is the so-called Tailored Heat Treatment technology. By a local short-term heat treatment, the material is softened and the material flow can be controlled to reduce stresses in critical forming zones. The purposeful definition of the heat treatment zones is mandatory to improve the forming results. Therefore, numerical methods are necessary. In this investigation, a numerical process chain is presented. It combines the thermo-mechanical simulation of a local laser heat treatment with a subsequent bending process of the heat-treated profile using the alloy EN AW-6082. The temperature distribution, mechanical properties, and finally, the bending result of the numerical model are validated by experimental tests.
A review on lung disease recognition by acoustic signal analysis with deep learning networks
Authors: Sfayyih Alyaa Hamel , Sulaiman Nasri , Sabry Ahmad H. 
Published: June 2023

AbstractRecently, assistive explanations for difficulties in the health check area have been made viable thanks in considerable portion to technologies like deep learning and machine learning. Using auditory analysis and medical imaging, they also increase the predictive accuracy for prompt and early disease detection. Medical professionals are thankful for such technological support since it helps them manage further patients because of the shortage of skilled human resources. In addition to serious illnesses like lung cancer and respiratory diseases, the plurality of breathing difficulties is gradually rising and endangering society. Because early prediction and immediate treatment are crucial for respiratory disorders, chest X-rays and respiratory sound audio are proving to be quite helpful together. Compared to related review studies on lung disease classification/detection using deep learning algorithms, only two review studies based on signal analysis for lung disease diagnosis have been conducted in 2011 and 2018. This work provides a review of lung disease recognition with acoustic signal analysis with deep learning networks. We anticipate that physicians and researchers working with sound-signal-based machine learning will find this material beneficial.
Detecting unregistered users through semi-supervised anomaly detection with similarity datasets
Authors: Heo Dong Hyuk , Park Sung Ho , Kang Soon Ju 
Published: June 2023

AbstractRecent research has focused on exploring systems that incorporate anomaly detection models to automate the addition of users in user recognition systems. Anomaly detection, a method used to distinguish between new and existing users by identifying abnormal images, has gained significant attention. Researchers have been actively investigating the Semi-Supervised Learning method, which utilizes only existing user data to differentiate between existing and new users. However, existing semi-supervised learning based anomaly detection models exhibit high performance on datasets with low similarity but experience a sharp decline in performance on datasets with high similarity. Furthermore, their large model size makes it challenging to execute them on edge nodes. To address these limitations, this paper proposes a model that can be executed on edge nodes and guarantees good performance on both low and high similarity datasets. The proposed model utilizes the LeNet-5, a user recognition model with fewer weights and multiple images as input, for classifying new users. This study compared the existing anomaly detection models with the proposed model using three datasets with varying similarities. The performance evaluation involved comparing the accuracy, ROC curve, and AUC of each model on a training server. Subsequently, the top three models were optimized for execution on the edge node (STM32F207ZG MCU) and further evaluated by comparing their accuracy, inference speed, and model size. The results revealed that the proposed model achieved an approximate 53% improvement in accuracy compared to the existing anomaly detection models. Furthermore, when executed on the edge node, the proposed model demonstrated significant memory savings, with a maximum reduction of approximately 530% and approximately 40% reduction in flash memory usage compared to the existing models.
Exploring the general practitioners’ point of view about clinical scores: a qualitative study
Authors: Pautrat Maxime , Palluau Remy , Druilhe Loic , Lebeau Jean Pierre 
Published: June 2023

AbstractBackgroundClinical scores help physicians to make clinical decisions, and some are recommended by health authorities for primary care use. As an increasing number of scores are becoming available, there is a need to understand general practitioner expectations for their use in primary care. The aim of this study was to explore general practitioner opinions about using scores in general practice.MethodThis qualitative study, with a grounded theory approach, used focus groups with general practitioners recruited from their own surgeries to obtain verbatim. Two investigators performed verbatim analysis to ensure data triangulation. The verbatim was double-blind labeled for inductive categorization to conceptualize score use in general practice.ResultsFive focus groups were planned, 21 general practitioners from central France participated. Participants appreciated scores for their clinical efficacy but felt that they were difficult to use in primary care. Their opinions revolved around validity, acceptability, and feasibility. Participants have little regard for score validity, they felt many scores are difficult to accept and do not capture contextual and human elements. Participants also felt that scores are unfeasible for primary care use. There are too many, they are hard to find, and either too short or too long. They also felt that scores were complex to administer and took up time for both patient and physician. Many participants felt learned societies should choose appropriate scores.DiscussionThis study conceptualizes general practitioner opinions about score use in primary care. The participants weighed up score effectiveness with efficiency. For some participants, scores helped make decisions faster, others expressed being disappointed with the lack of patient-centeredness and limited bio-psycho-social approach.
Sensing as the key to the safety and sustainability of new energy storage devices
Authors: Yi Zhenxiao , Chen Zhaoliang , Yin Kai , Wang Licheng , Wang Kai 
Published: June 2023

AbstractNew energy storage devices such as batteries and supercapacitors are widely used in various fields because of their irreplaceable excellent characteristics. Because there are relatively few monitoring parameters and limited understanding of their operation, they present problems in accurately predicting their state and controlling operation, such as state of charge, state of health, and early failure indicators. Poor monitoring can seriously affect the performance of energy storage devices. Therefore, to maximize the efficiency of new energy storage devices without damaging the equipment, it is important to make full use of sensing systems to accurately monitor important parameters such as voltage, current, temperature, and strain. These are highly related to their states. Hence, this paper reviews the sensing methods and divides them into two categories: embedded and non-embedded sensors. A variety of measurement methods used to measure the above parameters of various new energy storage devices such as batteries and supercapacitors are systematically summarized. The methods with different innovative points are listed, their advantages and disadvantages are summarized, and the application of optical fiber sensors is emphasized. Finally, the challenges and prospects for these studies are described. The intent is to encourage researchers in relevant fields to study the early warning of safety accidents from the root causes.
Effect of fermentation process on hygiene and perceived quality of lait caillé, an ethnic milk product from Burkina Faso
Authors: Bayili Geoffroy Romaric , Konkobo-Yaméogo Charlotte , Diarra Sinaly , Diawara Bréhima , Jespersen Lene , Sawadogo-Lingani Hagretou 
Published: June 2023

AbstractLait caillé is a traditional fermented milk product in Burkina Faso. The objective of this study was to contribute to consumer acceptance of lait caillé. For this purpose, the production practices in rural and urban areas were identified through semi-structured interviews, while the perceived quality of lait caillé in urban area was investigated through a survey. Then, microbiological and physico-chemical parameters were analysed on samples from rural and urban sites. Finally, an attempt to improve the hygiene of the traditional processing was proposed by use of Lactococcus lactis and Leuconostoc mesenteroides stains as starter. These were previously isolated from traditional lait caillé. The results on the manufacturing processes revealed from the raw milk practices of spontaneous fermentation, backslopping and contact with bacterial biofilms attached to container. The survey on perceived quality indicated that traditional lait caillé possessed a niche market which could be enlarged by implementation of good manufacturing practices in the production sites. The microbiota of the end product was characterised by high loads of Enterococcus spp., Enterobacteria and Pichia spp. Fermented milks by starter cultures showed improved hygienic quality and a positive sensory appreciation. However, the use of selected strains might be followed by loss of some features of traditional lait caillé, which scientists should work to resolve.
Study on systematic errors of BDS-3 broadcast ephemeris and their effects with Helmert transformation
Authors: Li Min , Zhang Jiangnan , Chen Guo , Chen Liang , Zhao Qile 
Published: June 2023

AbstractPrevious studies have not evaluated the systematic errors implied in the third generation of BeiDou-3 Navigation Satellite System (BDS-3) broadcast ephemeris. In this paper we evaluate the systematic pattern described by the Helmert transformation parameters, including translations, rotations, and scale. BDS-3 broadcast and precise ephemerides from December 2019 to 2022 are collected, and the characteristics of the transformation parameters as well as their effects on the signal in space error are analysed. The annual variation in the z-translation is obtained, and the similar amplitudes of 5.5 cm and phases of approximate 300 days are obtained for different years. When the rotation parameters are considered in the orbit comparison, the Root Mean Square (RMS) errors of the along- and cross-track orbital differences decrease from 29.1 to 12.5 cm and from 30.6 to 9.2 cm, respectively, because the three rotation parameters compensate for the majority of the errors in the BDS-3 broadcast ephemeris. Moreover, the high correlations in the obtained rotation parameters among the three orbital planes suggest that the orientation of the BDS-3 broadcast ephemeris is influenced by common model errors, i.e., uncertainty of Earth Rotation Parameters (ERPs). Further research is required because an offset of 1.5 × 10–9 for the scale parameter is observed. A degraded User Range Error (URE) for epochs of up to 84% is attained when the systematic pattern is considered, though the impact of the systematic pattern indicated by the z-translation and rotation parameters on the URE is less than 5.0 cm. With the refinement of the ERPs implemented in the new generation of broadcast ephemeris, we anticipate that the broadcast ephemeris performance of BDS-3 will be improved.
What’s beyond breast asymmetry? Comparative study between artificial intelligence and contrast-enhanced spectral mammography in the assessment of various types of breast asymmetries
Authors: Sobhi Aalaa , Mohammed Nada A. , Ali Engy A. 
Published: June 2023

Abstract
Background
Breast asymmetries are prevalent findings in mammograms and are commonly caused by variations in normal breast tissue. However, they may imply significant underlying causes in some cases. Such cases necessitate further assessment by adding further mammography views, targeted ultrasound, and investigations to exclude underlying pathology.

Objectives
To investigate the role of artificial intelligence (AI) compared to contrast-enhanced spectral mammography (CESM) in the assessment of breast asymmetries and their performance as diagnostic modality among different types of breast asymmetries as well as the additive value of AI software to mammography in these cases.

Methods
Sixty-four female patients were diagnosed with breast asymmetries by standard mammography (MMG) on both craniocaudal (CC) and mediolateral oblique (MLO). Digital breast tomosynthesis (DBT) may have been added. After evaluating the breast asymmetry by MMG and complementary breast ultrasound (US), both CESM and AI were performed for all cases and analyzed, then the interpreted results were compared accordingly either by histopathology from suspected lesions scored as BI-RADS 4 or 5 or through further close follow-up by single-view mammography in benign cases scored as BI-RADS 2 or 3.

Results
The sensitivity and specificity of CESM in the assessment of breast asymmetry in correlation with pathological data/follow-up results were 100% and 60% (p < 0.001). The corresponding values for AI were 70.83% and 75%; however, the estimated overall accuracy for both CESM and AI was close to each other measuring 75% and 73.44%, respectively (p < 0.001). The diagnostic accuracy of CESM to detect malignant causes of breast asymmetry was 100%; however, the detection of benign causes of breast asymmetry was 40%. The corresponding values for AI were 70.83% and 25%, respectively, with significant p-value (p < 0.001).

Conclusions
The CESM was more sensitive; however, the AI was more specific in the assessment of different breast asymmetries. Although the diagnostic accuracy of both is close to each other. Therefore, AI-aided reading can replace CESM in most cases, especially for those contraindicated to do CESM. AI also can reduce the radiation exposure hazards of a second dose of radiation for CESM and its financial cost as well. AI-aided reading in breast screening programs can reduce the recall of patients, unnecessary biopsies, and short-interval follow-up exams.
Celiac plexus neurolysis in pancreatic neoplasm with celiacomesenteric trunk: a case report
Authors: Paul Sounak , Mazumder Suparna , Mandal Sandip Swarup , Thakkar Dhaval Bhaveshkumar , Kukreja Prachi 
Published: June 2023

Abstract
Background
Celiac plexus neurolysis is an effective mode of long-term palliation of somatic pain in inoperable upper gastro-intestinal neoplasm. CT guidance is the most accepted method of localising the tip of the needle, through which, the neurolytic agent, commonly Absolute Alcohol, is introduced along the celiac ganglion. Three dimensional assessment of the retroperitoneal anatomy avoids injury to adjacent viscera and vascular structures. Para-aortic needle tip position between the origins of celiac and superior mesenteric arteries is an accepted position to inject neurolytic agent. We report a case of successful celiac plexus neurolysis in a patient with a celiacomesenteric trunk. Till date no such case has been reported, primarily due to the Low incidence of celiacomesenteric trunk.

Case presentation
A 63-year-old man developed progressive icterus and severe abdominal pain over 3 months. The pain severity was 6/10. An Ultrasonography and contrast enhanced CT of the abdomen revealed inoperable carcinoma of head of pancreas and a celiacomesenteric trunk. The pancreatic mass extended along the right lateral border of the celiacomesenteric trunk, not extending upto the aorta. Considering the severity of pain, poor compliance to opioid pain medication, and a possibility of early tumour extension upto the aortic margin, celiac plexus neurolysis was considered. The procedure was performed under CT guidance and local anaesthesia, using a mixture of absolute alcohol, Bupivacaine and diluted iodinated contrast. Bilateral paravertebral antecrural access was performed, using 22 gauge Chiba needles, after localisation on preprocedural CT-scan. On the left, hydrodissection was performed using normal saline, to displace the left renal parenchyma from the trajectory of the needle to be used for neurolysis. The patient’s pain visual analogue scale score reduced to 0/10, immediately after the procedure. He had a post procedural hypotension, managed conservatively by complete bed rest for 1 day and intravenous fluid administration.

Conclusions
Celiac plexus neurolysis can safely be done in aberrant upper abdominal vascular anatomy, under CT guidance and local anaesthesia. To avoid periprocedural complications, hydrodissection may be effectively used to displace normal anatomical structures from the trajectory of the access needle, through which a mixture of absolute alcohol and local anaesthetic may be delivered.
Association of Obstructive Sleep Apnea With Unanticipated Admission Following Nonotolaryngologic Pediatric Ambulatory Surgery
Authors: Willer Brittany L. , Petkus Holly , Manupipatpong Katherine , Tram Nguyen , Nafiu Olubukola O. , Tobias Joseph D. , Mpody Christian 
Published: June 2023

BACKGROUND:
Approximately 2% of ambulatory pediatric surgeries require unanticipated postoperative admission, causing parental dissatisfaction and suboptimal use of hospital resources. Obstructive sleep apnea (OSA) occurs in nearly 8% of children and is known to increase the risk of perioperative adverse events in children undergoing otolaryngologic procedures (eg, tonsillectomy). However, whether OSA is also a risk for unanticipated admission after nonotolaryngologic surgery is unknown. The objectives of this study were to determine the association of OSA with unanticipated admission after pediatric nonotolaryngologic ambulatory surgery and to explore trends in the prevalence of OSA in children undergoing nonotolaryngologic ambulatory surgery.

METHODS:
We used the Pediatric Health Information System (PHIS) Database to evaluate a retrospective cohort of children (<18 years) undergoing nonotolaryngologic surgery scheduled as ambulatory or observation status from January 1, 2010, to August 31, 2022. We used International Classification of Diseases codes to identify patients with OSA. The primary outcome was unanticipated postoperative admission lasting ≥1 day. Using logistic regression models, we estimated the odds ratio (OR) and 95% confidence intervals (CIs) for unanticipated admission comparing patients with and without OSA. We then estimated trends in the prevalence of OSA during the study period using the Cochran-Armitage test.

RESULTS:
A total of 855,832 children <18 years underwent nonotolaryngologic surgery as ambulatory or observation status during the study period. Of these, 39,427 (4.6%) required unanticipated admission for ≥1 day, and OSA was present in 6359 (0.7%) of these patients. Among children with OSA, 9.4% required unanticipated admission, compared to 5.0% among those without. The odds of children with OSA requiring unanticipated admission were more than twice that in children without OSA (adjusted OR, 2.27; 95% CI, 1.89–2.71; P < .001). The prevalence of OSA among children undergoing nonotolaryngologic surgery as ambulatory or observation status increased from 0.4% to 1.7% between 2010 and 2022 (P trends < .001).

CONCLUSIONS:
Children with OSA were significantly more likely to require unanticipated admission after a nonotolaryngologic surgery scheduled as ambulatory or observation status than those without OSA. These findings can inform patient selection for ambulatory surgery with the goal of decreasing unanticipated admissions, increasing patient safety and satisfaction, and optimizing health care resources related to unanticipated admission.
The Symptomatological Imagination
Authors: Baasch Kyle 
Published: June 2023

AbstractCultural and literary critics have begun to abandon a long-standing commitment to poststructuralist and deconstructive interpretative methods in favor of an ostensibly Marxist aspiration to comprehend cultural phenomena as symptomatic expressions of a social totality. This essay identifies some of the advantages and shortcomings of this symptomatological mode of interpretation by returning to a dispute in the German scientific establishment around the turn of the twentieth century concerning the applicability of biological conceptions of organic wholeness in cultural and social analysis. The dispute culminates in Max Weber’s nuanced defense of biological metaphors as indispensable heuristic devices for cultural inquiry that can nevertheless result in dangerous consequences when they are inappropriately employed. This essay ultimately argues that Weber’s contribution to cultural analysis remains an underappreciated and vital methodological resource for researchers who wish to rehabilitate the concept of totality today.