bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doctors’ experiences when treating doctor–patients: a scoping review
Authors: Hutton Claire J , Kay Margaret , Round Penny , Barton Chris 
Published: July 2023

BackgroundTo work effectively, doctors need to look after themselves. They often delay seeking medical care for a range of reasons. Once they do, there is evidence that the doctors treating them (’treating doctors’) can struggle to provide optimal care.AimTo examine existing literature on what is currently known about experiences for treating doctors, in particular GPs, when their patient is also a doctor.Design & settingA scoping review of articles written in English.MethodUsing the JBI methodological framework for scoping reviews, five databases (MEDLINE, PsycINFO, CINAHL [Cumulative Index to Nursing & Allied Health], Google Scholar, and Scopus) were searched from the database start date until 31 December 2022. Qualitative and quantitative studies reporting the treating doctor’s experience, guidelines for treating doctors, expert opinion articles, and editorials were included. Grey literature was considered, searching the first 10 pages of two Google searches.ResultsForty-eight articles from eight countries met inclusion criteria, of which 12 were research studies. The main areas of focus were as follows: affective responses, which included anxiety about being criticised, concern about upsetting the doctor–patient, and discomfort regarding the acknowledgement that doctors get sick; relational factors, which included boundary issues, over-identifying with the doctor–patient, treating them as a colleague rather than a patient, and role ambiguity; confidentiality, which incorporated both affective and relational aspects; and influence of medical culture and socialisation on dynamics between treating doctor and doctor–patient. These findings have been distilled into a list of key suggestions for the treating doctor.ConclusionDoctors can find treating doctor–patients anxiety-provoking and challenging. The sources of this discomfort are multifaceted, and more empirical research is needed to better understand and address the complex relationship between treating doctor and doctor–patient.
L’acceptation de l’indemnisation du préjudice d’anxiété lié à l’exposition à l’amiante d’un travailleur par l’entreprise utilisatrice
Authors: Maimone Pierrick 
Published: July 2023

Depuis que la Cour de cassation a admis la réparation du préjudice d’anxiété d’un salarié exposé à l’amiante, elle n’a eu de cesse d’ouvrir de nouvelles voies d’indemnisation. Par un arrêt du 8 février 2023, la Cour de cassation vient d’en créer une autre : le salarié exposé à l’amiante peut également engager la responsabilité civile délictuelle de l’entreprise utilisatrice, au sein de laquelle il a travaillé.
The use of pegaspargase in adult Ph-negative acute lymphoblastic leukemia patients in the treatment according to the all-2016 protocol
Authors: Aleshina O. A. , Kotova E. S. , Isinova G. A. , Grishunina M. E. , Sveshnikova J. V. , Kaplanov K. D. , Bondarenko S. N. , Zinina E. E. , Chabaeva Yu. A. , Parovichnikova E. N. 
Published: July 2023

Introduction. There are several forms of the L-asparaginase which are characterized by differences in the half-life, the spectrum of toxicity as well as other factors.Aim — to determine the incidence of different types of L-asparaginase toxicity in adult patients with Ph-negative acute lymphoblastic leukemia (ALL) treated according to the ALL-2016 protocol.Materials and methods. From December 2016 to February 2023 the multicenter prospective randomized study “ALL-2016” included 313 patients with newly diagnosed Ph-negative ALL. Information about the 256 patients who had toxicity of native L-asparaginase was entered into an electronic database. The ratio of men and women was 155:101. The median age was 32 (18–54) years. We analyzed 1253 courses of therapy that included the administration of L-asparaginase.Results. L-asparaginase toxicity and adverse reactions were diagnosed in 67 (26 %) of 256 patients. Of the 1253 courses, 102 (8 %) had complications associated with the administration of this drug. Grade 1–2 toxicity of L-asparaginase was diagnosed in 34 (51 %) patients: allergic reaction — in 6 (18 %), thrombosis of brachiocephalic veins associated with the installation of a central venous catheter — in 2 (6 %), increased pancreatic amylase in blood serum and diastase in urine, without clinical signs of pancreatitis — in 3 (9 %), lower protein-synthesis function of liver — in 23 (68 %), hepatotoxicity — in 15 (44 %). Grade 3–4 toxicity of L-asparaginase was diagnosed in 33 (49 %) patients, of which 22 (67 %) required discontinuation of the drug. The median of the development of complications of L-asparaginase was the third administration. None of the patients died as the result of the toxicity of native form of the drug. The 5-year overall survival (OS) and the probability of relapse (PR) in the group of patients in which L-asparaginase was discontinued at the stage of induction of remission and in the group of patients who continued L-asparaginase treatment at remission consolidation and maintenance therapy did not differ significantly: OS — 89 % vs 70 % (p = 0.0921), PR — 47 % vs 33 % (р = 0.8633).Conclusion. In adult patients, L-asparaginase withdrawal due to toxicity, in most cases, occurs at the stage of the remission induction. It is possible that the replacement of the native form the drug to the pegylated one in adult patients with ALL, in whom L-asparaginase is canceled at the stage of remission induction, improves long-term survival rates.
The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management
Authors: Görlinger K. , Pérez-Ferrer A. , Dirkmann D. , Saner F. , Maegele M. , Calatayud A. A. P. , Kim T.-Y. 
Published: July 2023

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part of patient blood management (PBM) which is an important concept in improving patient safety. Here, ROTEM testing and hemostatic interventions should be linked by evidence-based, setting-specific algorithms adapted to the specific patient population of the hospitals and the local availability of hemostatic interventions. Accordingly, ROTEM-guided algorithms implement the concept of personalized or precision medicine in perioperative bleeding management (“theranostic” approach). ROTEM-guided PBM has been shown to be effective in reducing bleeding, transfusion requirements, complication rates, and health care costs. Accordingly, several randomized-controlled trials, meta-analyses, and health technology assessments provided evidence that using ROTEM-guided algorithms in bleeding patients resulted in improved patient’s safety and outcomes including perioperative morbidity and mortality. However, the implementation of ROTEM in the PBM concept requires adequate technical and interpretation training, education and logistics, as well as interdisciplinary communication and collaboration.
Collection, transportation and storage of blood during the Great Patriotic War
Authors: Kamelskikh D. V. , Serebryany R. S. 
Published: July 2023

Introduction. Blood collection technologies were of great importance during the Great Patriotic War. This was due to the need to increase the shelf life, simplify the transportation process and ensure the safety (including the exclusion of bacterial contamination) of transfusions.Aim — to describe the technologies for blood collection and transfusion, alternatives to blood transfusion and measures aimed at organizing the collection and clinical use of blood in the Great Patriotic War.Main findings. This article describes the process of collecting donated blood during the Great Patriotic War. Methods of preparing a donor for the procedure, technological methods at the time of taking blood from primary and repeated donors (anesthesia, intervals between donations, etc.) are shown. Methods for the preparation of citrated blood, preserved blood, cadaveric blood, defibrinated and placental blood are described. The labor-intensive procedure used in those years required a scrupulous attitude to the preparation of equipment and solutions. Marking, storage and transportation of donated blood were of great importance.
The Effect Differences of Learning Approach, Hitting Distance, and Kinesthetic Perception on Tennis Groundstroke Ability
Authors: Hidayah Taufiq , Pratama Rivan Saghita , Akhiruyanto Andry , Haryono Sri , Setiawan Arif , Nurrachmad Limpad , Utanto Yuli , Maretta Yoris Adi 
Published: July 2023

AIM: The purpose of this study was to determine the difference in the effect of the learning approach, hitting distance, and kinesthetic perception on the ability of tennis groundstrokes.
METHODS: In conducting this research, researchers used an experimental method with a 2 × 2 × 2 factorial design. The research sample was 40 athletes with a purposive random sampling technique. The data collection technique used was a kinesthetic perception test and a tennis groundstroke ability test. The analysis technique used was Analysis of Variance at the significance level α = 0.05.
RESULTS: The results showed that (1) There is a significant difference in the effect of the learning approach on the groundstroke ability of tennis court with the calculated F value (Fo) = 4.941 greater than F table (Ft) = 3.26, (2) There is no significant difference between the fixed hitting distance and the gradual hitting distance on the ability of tennis groundstrokes with the calculated F value (Fo) = 2.196 which is smaller than F table (Ft) = 3.26, (3) There is a significant difference in the effect between students who have good kinesthetic perception and less kinesthetic perception on tennis groundstroke ability with the calculated F value (Fo) = 11.473 greater than F table (Ft) = 3.26, (4) There is no interaction between the learning approach and hitting distance on the ability of tennis groundstrokes with the calculated F value (Fo) = 3.238 which is smaller than F table (Ft) = 3.26, (5) There is no interaction between the learning approach and the kinesthetic perception of tennis groundstroke ability with the calculated F value (Fo) = 0.908 which is smaller than F table (Ft) = 3.26, (6) There is no interaction between hitting distance and kinesthetic perception on the ability of tennis groundstrokes with the calculated F value (Fo) = 2.868 which is smaller than F table (Ft) = 3.26, (7) There is an interaction between the learning approach, hitting distance, and students’ kinesthetic perceptions of the tennis groundstroke ability with the calculated F value (Fo) = 9.423 greater than F table (Ft) = 3.26.
CONCLUSION: Overall, there is an interaction between the three variables of the training model, meaning that the learning outcomes of the tennis groundstroke ability are obtained due to regular exercise. The achievement of the groundstroke ability of the tennis court due to the application of the learning approach is directly influenced by the difference between the distance and the difference in the student’s kinesthetic perception.
Panthéon aztèque et rites des vingtaines. L’organisation et le contenu du Libro de los Ritos de Diego Durán
Authors: Peperstraete Sylvie 
Published: July 2023

Diego Durán (ca. 1537-1588), religieux dominicain ayant passé la majeure partie de sa vie en Nouvelle-Espagne, est l’auteur d’un volumineux ouvrage sur les civilisations autochtones de l’actuel Mexique central : l’Historia de las Indias de Nueva España y islas de Tierra Firme (1581)1. Le séminaire 2021-2022 a poursuivi les recherches précédemment entamées sur les pages qu’il consacra à la religion aztèque […]
Anthropologie de l’invisible
Authors: Delaplace Grégory 
Published: July 2023

C’est par un travail autour du concept d’invisible que j’ai entrepris d’inaugurer la chaire d’anthropologie du religieux de l’École pratique des hautes études. Cela permettait, en premier lieu, de récapituler les recherches menées ces dernières années dans deux situations différentes, envisagées parallèlement, qui engagent chacune un rapport particulier à l’anthropologie et à ses méthodes […]
Anthropologie linguistique du religieux
Authors: Vapnarsky Valentina 
Published: July 2023

Pour notre première année de conférences à l’EPHE, nous avons choisi d’initier un cycle « Anthropologie linguistique de la parole rituelle : vocalités, textualités, transformations ». Celui-ci conjugue la présentation et l’analyse de matériaux sur les Mayas, à une approche comparative et théorique développée grâce à l’invitation de collègues spécialistes d’autres aires […]
Origines du christianisme
Authors: Piovanelli Pierluigi 
Published: July 2023

Les conférences de cette année ont porté, respectivement, sur (1) « Paul de Tarse dans la recherche actuelle : enjeux et perspectives », et (2) « Un Judéen messianiste en mission auprès des nations ». Il s’agit de la deuxième année d’un programme de recherche qui a débuté en 2020-2021 et qui s’achèvera en 2022-2023.
Arts majeurs, arts mineurs. Genèse et premiers développements de l’imaginaire figuratif chrétien dans l’art de l’Antiquité tardive
Authors: Bisconti Fabrizio 
Published: July 2023

Nous donnons ici le texte du projet de conférences présenté en 2019 ; elles devaient avoir lieu en mars 2020. La première se tint devant une assistance nombreuse le 6 mars 2020. La conférence suivante prévue pour le 13 mars ne put être donnée en raison des mesures de restriction des libertés publiques prises en Italie puis en France dans le dessein de lutter contre la pandémie de la Covid 19. Ce n’est qu’à l’automne 2021 que F. Bisconti put revenir à Paris et y tenir le reste de ses conférences, exceptionnellement regroupées sur trois jours consécutifs, les 16-18 novembre 2021. Le soussigné rencontra pour la dernière fois Fabrizio Bisconti les 23-24 février 2022 à l’occasion du colloque organisé à Rome à la catacombe de Calliste, au Palazzo della Cancelleria et à la Protomoteca Capitolina pour célébrer le bicentenaire de la naissance de Giovanni Battista de Rossi. Les Actes en ont été tout récemment publiés (R. Giuliani, B. Mazzei, D. Mazzoleni, C. Salvetti [éd.], Il secolo di Giovanni Battista de Rossi [1822-1894]. La cultura archeologica dall’Italia all’Europa. Atti del convegno di studi, Cité du Vatican 2022). Ce fut là l’une des dernières apparitions publiques de F. Bisconti ; en à peine quelques semaines il fut brutalement et inexorablement emporté par la maladie : voir les nécrologies de Ph. Pergola, Pontificio Istituto di Archeologia Cristiana. Programma. Anno accademico (2022-2023), p. 13-16 (https://www.piac.it/piac/wp-content/uploads/2022/08/Programma-AA-2022-2023-per-sito-1.pdf) et de D. Mazzoleni, Rivista di archeologia cristiana 98 (2022/2), p. 229-235 [M.-Y. Perrin].
Citoyenneté et normalité
Authors: Liljeström Marianne 
Published: July 2023

La notion de « citoyenneté sexuelle » est généralement utilisée pour parler spécifiquement des droits sexuels accordés ou refusés aux différents groupes. Cependant, cette notion peut aussi – dans le contexte d’un discours sur la citoyenneté qui défend la « normalité » d’être gay – être conceptualisée dans un sens beaucoup plus large et appliquée à la relation entre l’hétérosexualité et la pleine citoyenneté de manière plus détaillée. Cet article traite de la construction de la citoyenneté à travers les processus de normalisation, d’assimilation et d’intégration des sujets queer, en problématisant particulièrement la division conceptuelle entre le privé et le public. Ce texte avance finalement comme thèse que, dans les politiques queer – contrairement aux politiques d’identité gay et au lieu de normaliser la morale –, il s’agit de repenser la citoyenneté démocratique et de reconstruire la vie individuelle et collective en imaginant des corps, des soi et des intimités façonnés et organisés dans un ordre social non normalisant.
Exposer la loi. L’application de la loi norvégienne sur le recours aux services sexuels
Authors: Jahnsen Synnøve Økland 
Published: July 2023

Depuis plus de vingt ans, et ce au niveau international, la lutte contre le trafic humain est devenue une question politique majeure. L’attention se portant principalement sur la prostitution et les différentes manières de la combattre, on pourrait dire que ce coup de projecteur a dans le même temps laissé dans l’ombre les autres formes de trafic humain. Cet article a pour but d’interroger « la pensée de modèles » qui caractérise les débats internationaux sur la prostitution et de poser un regard critique sur la formule nordique prétendument couronnée de succès que serait la pénalisation du recours aux services sexuels dans la lutte pour une société plus égalitaire. L’article décrit les changements récents dans les politiques norvégiennes en matière de prostitution et démontre que les mécanismes d’exclusion dans les États providence traditionnels poussent les ressortissants de pays étrangers vers les domaines de la politique pénale.
Gouverner la sexualité des couples : des cours pour les couples financés par l’état norvégien
Authors: Danielsen Hilde , Ludvigsen Kari , Mühleisen Wenche 
Published: July 2023

Cet article se propose d’analyser la construction de la sexualité des couples norvégiens telle que la présente un cours mis en place et financé par l’État à l’intention des couples appelés à devenir parents pour la première fois. Intitulé « Bien vivre ensemble » (« Godt Samliv »), ce cours, lancé en 2005, est proposé gratuitement par les Centres de santé publique. De l’analyse des documents officiels, des débats politiques et des manuels utilisés pour cet enseignement, il ressort un discours sur la sexualité spécifiquement norvégien où l’accent est mis aussi bien sur l’égalité et la neutralité du genre que sur l’idée d’une démocratisation inclusive. Les jeunes parents sont encouragés à tout faire pour maintenir une relation durable et une vie sexuelle active permettant de favoriser le bien-être des enfants. L’idée de la sexualité qu’implique cette politique conjugale est fondée sur ce que l’on pourrait appeler « le devoir de spontanéité », lequel est présenté comme une tâche à laquelle les deux parents doivent s’atteler afin d’entretenir une relation stable et saine. À notre sens, cependant, telle qu’elle apparaît dans la politique gouvernementale sur la sexualité, cette rhétorique inclusive prônant la diversité a des limites, son discours excluant certaines formes d’intimité et de sexualité.
Bacillus Calmette-Guérin–Trained Macrophages Elicit a Protective Inflammatory Response against the Pathogenic Bacteria Brucella abortus
Authors: de Araujo Ana Carolina V S C , de Queiroz Nina M G P , Marinho Fábio V , Oliveira Sergio C 
Published: July 2023

Abstract
The bacillus Calmette-Guérin (BCG) can elicit enhanced innate immune responses against a wide range of infections, known as trained immunity. Brucella abortus is the causative agent of brucellosis, a debilitating disease that affects humans and animals. In this study, we demonstrate that C57BL/6 mouse bone marrow–derived macrophages under BCG training enhance inflammatory responses against B. abortus. BCG-trained macrophages showed increased MHC class II and CD40 expression on the cell surface and higher IL-6, IL-12, and IL-1β production. The increase in IL-1β secretion was accompanied by enhanced activation of canonical and noncanonical inflammasome platforms. We observed elevated caspase-11 expression and caspase-1 processing in BCG-trained macrophages in response to B. abortus compared with untrained cells. In addition, these BCG-trained cells showed higher NLRP3 expression after B. abortus infection. From a metabolic point of view, signaling through the Akt/mammalian target of rapamycin/S6 kinase pathway was also enhanced. In addition, BCG training resulted in higher inducible NO synthase expression and nitrite production, culminating in an improved macrophage-killing capacity against intracellular B. abortus. In vivo, we monitored a significant reduction in the bacterial burden in organs from BCG-trained C57BL/6 mice when compared with the untrained group. In addition, previous BCG immunization of RAG-1–deficient mice partially protects against Brucella infection, suggesting the important role of the innate immune compartment in this scenario. Furthermore, naive recipient mice that received BM transfer from BCG-trained donors showed greater resistance to B. abortus when compared with their untrained counterparts. These results demonstrate that BCG-induced trained immunity in mice results in better control of intracellular B. abortus in vivo and in vitro.
FLUDARABINE-BASED LOW-INTENSITY CONDITIONING FOR FANCONI ANEMIA IS ASSOCIATED WITH GOOD OUTCOMES IN APLASTIC ANEMIA BUT NOT IN MDS - A SINGLE-CENTER EXPERIENCE
Authors: George Biju , Chattopadhyay Sohini , Lionel Sharon , Selvarajan Sushil , Devasia Anup , Korula Anu , Kulkarni Uday , Aboobacker Fouzia , Sindhuvi Eunice , Lakshmi Kavitha , Srivastava Alok , Abraham Aby , Mathews Vikram 
Published: July 2023

Background: Hematopoietic stem cell transplantation [HSCT] is the only curative option for Fanconi Anemia (FA) patients with hematological abnormalities.
Materials and Methods: This is a retrospective analysis of patients with FA who underwent a matched-related donor HSCT.
Results: Sixty patients underwent 65 transplants between 1999-2021 using a fludarabine-based low-intensity conditioning regimen. The median age at transplant was 11 years (range: 3-37). Aplastic anemia (AA) was the underlying diagnosis in 55 (84.6%) while 8 (12.4%) had myelodysplastic syndrome (MDS) and 2 (3%) had acute myeloid leukemia (AML). The conditioning regimen used was fludarabine with low-dose cyclophosphamide for aplastic anemia and Fludarabine with low-dose busulfan for MDS/AML. Graft versus host disease (GVHD)prophylaxis consisted of cyclosporine and methotrexate. Peripheral blood stem cells was the predominant graft source (86.2%). Engraftment occurred in all but 1 patient. The median time to neutrophil and platelet engraftment was 13 days (range: 9-29) & 13 days (range: 5-31), respectively. Day 28 chimerism analysis showed complete chimerism in 75.4 % and mixed chimerism in 18.5%. Secondary graft failure was encountered in 7.7%. Grade II–IV acute GVHD occurred in 29.2% while Grade III-IV acute GVHD occurred in 9.2%. Chronic GVHD was seen in 58.5% and was limited in most patients. The median follow-up is 55 months [range: 2-144] & the 5-year estimated overall survival (OS) is 80.2 ± 5.1%. Secondary malignancies were noted in 4 patients. The 5-year OS was significantly higher in patients undergoing HSCT for AA (86.6 + 4.7%) as compared to MDS/AML (45.7+16.6%) (p= 0.001).
Conclusion: SCT using a fully matched donor provides good outcomes with low-intensity conditioning regimens in patients with FA who have an aplastic marrow.