bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults
Authors: Acosta Julián N , Haider Stefan P , Rivier Cyprien , Leasure Audrey C , Sheth Kevin N , Falcone Guido J , Payabvash Seyedmehdi 
Published: March 2023

Background and objectivesWe aimed to investigate the white matter (WM) microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure (SBP), and whether they mediate SBP effects on cognitive performance in middle-aged adults.MethodsUsing the UK Biobank study of community-dwelling volunteers aged 40–69 years, we included participants without a history of stroke, dementia, demyelinating disease or traumatic brain injury. We investigated the association of SBP with MRI diffusion metrics: fractional anisotropy (FA), mean diffusivity (MD), intracellular volume fraction (a measure of neurite density), isotropic (free) water volume fraction (ISOVF) and orientation dispersion across WM tracts. Then, we determined whether WM diffusion metrics mediated the effects of SBP on cognitive function.ResultsWe analysed 31 363 participants—mean age of 63.8 years (SD: 7.7), and 16 523 (53%) females. Higher SBP was associated with lower FA and neurite density, but higher MD and ISOVF. Among different WM tracts, diffusion metrics of the internal capsule anterior limb, external capsule, superior and posterior corona radiata were most affected by higher SBP. Among seven cognitive metrics, SBP levels were only associated with ‘fluid intelligence’ (adjusted p<0.001). In mediation analysis, the averaged FA of external capsule, internal capsule anterior limb and superior cerebellar peduncle mediated 13%, 9% and 13% of SBP effects on fluid intelligence, while the averaged MD of external capsule, internal capsule anterior and posterior limbs, and superior corona radiata mediated 5%, 7%, 7% and 6% of SBP effects on fluid intelligence, respectively.DiscussionAmong asymptomatic adults, higher SBP is associated with pervasive WM microstructure disintegrity, partially due to reduced neuronal count, which appears to mediate SBP adverse effects on fluid intelligence. Diffusion metrics of select WM tracts, which are most reflective of SBP-related parenchymal damage and cognitive impairment, may serve as imaging biomarkers to assess treatment response in antihypertensive trials.
Smoke-free law compliance and predictive factors in Ethiopia: observational assessment of public places and workplaces
Authors: Mengesha Sisay Derso , Shimeles Bitsat , Zewdie Baharu , Alermu Asnakech , Gerba Heran , Gartner Coral E 
Published: March 2023

ObjectivesThe primary objective of this observational study was to assess the status of public place and workplace compliance with smoke-free provisions in Ethiopia.MethodsThis study was conducted in four regions of Ethiopia (Oromia; Sidama; Harari; and Southern Nations, Nationalities, and Peoples’ Region) from September to October 2021. Data were collected using a standardised smoke-free checklist. Χ2tests were used to assess the association between categorical variables and the smoke-free status. Multivariable binary logistic regression analysis was used to identify factors associated with the presence of at least one person actively smoking.ResultsApproximately 97% (95% CI 93.1%, 98.8%) of government buildings, 92.5% (95% CI 85.7%, 96.2%) of educational institutions, 89.8% (95% CI 86.3%, 92.5%) of bars, restaurants and cafés, 88.4% (95% CI 82.9%, 92.3%) of food establishments and 84.0% of hotels (95% CI 79.5%, 87.6%) were non-compliant with the tobacco control law. Overall, only 12.3% of sites met the requirements of the current smoke-free law. The multivariable logistic regression models showed that transit facilities (adjusted OR (AOR)=26.66 (95% CI 7.53, 94.41)) and being located in the Harari region (AOR=4.14 (95% CI 2.30, 7.45)) were strongly associated with the presence of active smoking observed during the site visit.ConclusionThis study indicated that public place and workplace non-compliance level was very high in all sites. This calls for more effective implementation of complete smoke-free provisions across all government buildings and institutions in all regions, such as public educational campaigns about the laws and enforcement action for non-compliance. Furthermore, all regional states should adopt Federal Proclamation 1112/2019.
Industry marketing of tobacco products on social media: case study of Philip Morris International’s IQOS
Authors: Abroms Lorien C , Wysota Christina N , Tosakoon Sararat , Khayat Amal , Duan Zongshuan , Bar-Zeev Yael , Berg Carla J , Levine Hagai 
Published: March 2023

Significance
Newer tobacco products might be particularly likely to use social media as they emerge in the global market. Little is known about the official use of social media in marketing heated tobacco products (HTPs). This study examined Philip Morris International’s (PMI) social media marketing globally of its leading HTP, IQOS.

Methods
PMI IQOS country-specific official websites were accessed (N=59) in May to September 2022 and social media accounts listed were recorded. Accounts were then coded for their number of posts in the past month and year and for their number of subscribers. Posts on online accounts with at least one past-month post were categorised to describe the post’s function: instructional, general advertising, price promotions or event promotions.

Results
Of the 59 country websites, 45 (76.3%) listed at least one social media account; of these, an average of 2.5 accounts (SD=0.8) were listed. Across websites, 111 accounts were identified: 42 Facebook, 23 YouTube, 21 Twitter, 19 Instagram, 2 Telegram, 1 LinkedIn, 1 KakaoTalk, 1 VK and 1 LINE. Across YouTube, Twitter and Instagram, accounts made 2550 past-year posts and had ~490 961 subscribers. Of the 165 past-month posts, 101 (60.1%) functioned as general advertising, 30 (17.9%) instructional, 29 (17.3%) event promotions and 8 (4.8%) price promotions.

Conclusion
Social media posts were used to engage consumers with advertising, event promotions, product use instructions and price promotions. The study provides evidence of the company-sponsored official marketing of an HTP via social media globally, underscoring the need for monitoring and tobacco control regulatory efforts in the digital arena.
Screening and intervention for intimate partner violence at trauma centers and emergency departments: an evidence-based systematic review from the Eastern Association for the Surgery of Trauma
Authors: Teichman Amanda L , Bonne Stephanie , Rattan Rishi , Dultz Linda , Qurashi Farheen A , Goldenberg Anna , Polite Nathan , Liveris Anna , Freeman Jennifer J , Colosimo Christina , Chang Erin , Choron Rachel L , Edwards Courtney , Arabian Sandra , Haines Krista L , Joseph D'Andrea , Murphy Patrick B , Schramm Andrew T , Jung Hee Soo , Lawson Emily , Fox Kathleen , Mashbari Hassan Naser A , Smith Randi N 
Published: March 2023

BackgroundIntimate partner violence (IPV) is a serious public health issue with a substantial burden on society. Screening and intervention practices vary widely and there are no standard guidelines. Our objective was to review research on current practices for IPV prevention in emergency departments and trauma centers in the USA and provide evidenced-based recommendations.MethodsAn evidence-based systematic review of the literature was conducted to address screening and intervention for IPV in adult trauma and emergency department patients. The Grading of Recommendations, Assessment, Development and Evaluations methodology was used to determine the quality of evidence. Studies were included if they addressed our prespecified population, intervention, control, and outcomes questions. Case reports, editorials, and abstracts were excluded from review.ResultsSeven studies met inclusion criteria. All seven were centered around screening for IPV; none addressed interventions when abuse was identified. Screening instruments varied across studies. Although it is unclear if one tool is more accurate than others, significantly more victims were identified when screening protocols were implemented compared with non-standardized approaches to identifying IPV victims.ConclusionOverall, there were very limited data addressing the topic of IPV screening and intervention in emergency medical settings, and the quality of the evidence was low. With likely low risk and a significant potential benefit, we conditionally recommend implementation of a screening protocol to identify victims of IPV in adults treated in the emergency department and trauma centers. Although the purpose of screening would ultimately be to provide resources for victims, no studies that assessed distinct interventions met our inclusion criteria. Therefore, we cannot make specific recommendations related to IPV interventions.PROSPERO registration numberCRD42020219517.
Improving the Computational Efficiency of ROVIO
Authors: Bahnam S. A. , De Wagter C. , de Croon G. C. H. E. 
Published: March 2023

ROVIO is one of the state-of-the-art monocular visual inertial odometry algorithms. It uses an Iterative Extended Kalman Filter (IEKF) to align visual features and update the vehicle state simultaneously by including the feature locations in the state vector of the IEKF. This algorithm is single-core intensive, which allows the other cores to be used for other algorithms, such as object detection and path optimization. However, the computational cost of the algorithm grows rapidly with the maximum number of features to track. Each feature adds three new states (a 2D bearing vector and inverse depth), leading to bigger matrix multiplications that are computationally expensive. The main computational load of ROVIO is the iterative update step of the IEKF. In this work, we reduce the average computational cost of ROVIO by [Formula: see text] on an NVIDIA Jetson TX2, without affecting the accuracy of the algorithm. This computational gain is mainly achieved by exploiting the sparse matrices in ROVIO. Furthermore, we reduce the computational peaks by pre-selecting new features based on their already calculated FAST score. The combination of both modifications allows us to run ROVIO on the computationally restricted Raspberry Pi Zero 2[Formula: see text]W.
A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
Authors: Jang H. Josh , Hostetter Galen , Macfarlane Alexander W. , Madaj Zachary , Ross Eric A. , Hinoue Toshinori , Kulchycki Justin R. , Burgos Ryan S. , Tafseer Mahvish , Alpaugh R. Katherine , Schwebel Candice L. , Kokate Rutika , Geynisman Daniel M. , Zibelman Matthew R. , Ghatalia Pooja , Nichols Peter W. , Chung Woonbok , Madzo Jozef , Hahn Noah M. , Quinn David I. , Issa Jean-Pierre J. , Topper Michael J. , Baylin Stephen B. , Shen Hui , Campbell Kerry S. , Jones Peter A. , Plimack Elizabeth R. 
Published: March 2023

AbstractPurpose:On the basis of preclinical evidence of epigenetic contribution to sensitivity and resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine (hypomethylating agent) and atezolizumab [anti–programmed cell death ligand 1 (PD-L1)] together would potentiate a clinical response in patients with metastatic urothelial carcinoma (UC) unresponsive to initial immune checkpoint blockade therapy.Patients and Methods:We designed a single arm phase II study (NCT03179943) with a safety run-in to identify the recommended phase II dose of the combination therapy of guadecitabine and atezolizumab. Patients with recurrent/advanced UC who had previously progressed on ICI therapy with programmed cell death protein 1 or PD-L1 targeting agents were eligible. Preplanned correlative analysis was performed to characterize peripheral immune dynamics and global DNA methylation, transcriptome, and immune infiltration dynamics of patient tumors.Results:Safety run-in enrolled 6 patients and phase II enrolled 15 patients before the trial was closed for futility. No dose-limiting toxicity was observed. Four patients, with best response of stable disease (SD), exhibited extended tumor control (8–11 months) and survival (&gt;14 months). Correlative analysis revealed lack of DNA demethylation in tumors after 2 cycles of treatment. Increased peripheral immune activation and immune infiltration in tumors after treatment correlated with progression-free survival and SD. Furthermore, high IL6 and IL8 levels in the patients’ plasma was associated with short survival.Conclusions:No RECIST responses were observed after combination therapy in this trial. Although we could not detect the anticipated tumor-intrinsic effects of guadecitabine, the addition of hypomethylating agent to ICI therapy induced immune activation in a few patients, which associated with longer patient survival.
Prognostic Value of Transthoracic Echocardiography in Children With Pulmonary Arterial Hypertension
Authors: Lammers Astrid E. , Marek Jan , Diller Gerhard‐Paul , Haworth Sheila G. , Moledina Shahin 
Published: March 2023

Background
Transthoracic echocardiography is part of the regular follow‐up protocol at most pediatric pulmonary arterial hypertension (PAH) centers. We aimed to develop a comprehensive and simple echocardiographic risk stratification for children with PAH.

Methods and Results

We included 63 children with PAH and a biventricular cardiac anatomy without relevant shunt lesions (60% female patients; mean age, 9.0 years; 42 idiopathic PAH and 21 associated PAH) undergoing a standardized transthoracic echocardiographic assessment. The prognostic value of echocardiographic parameters was assessed using Cox proportional hazards survival analysis and recursive partitioning for classification tree methods. Over a median follow‐up period of 4.0 years, 17 patients died and 4 underwent lung transplantation. Various echocardiographic parameters were associated with the combined endpoint of death and transplantation on univariate analysis. On further analysis, right atrial area (
z
score) and left ventricular diastolic eccentricity index (LVEId) emerged as robust and independent predictors of transplant‐free survival. Considering mortality alone as an end point, a combination of right atrial area, left ventricular diastolic eccentricity index, and tricuspid annular plane systolic excursion were identified as independent predictors of outcome. Based on these parameters, we propose simple risk scores that can be applied at the bedside without computer assistance.

CONCLUSIONS
Echocardiographic parameters predict prognosis in children with pulmonary hypertension. A combination of widely available parameters including right atrial area, left ventricular eccentricity index, and tricuspid annular plane systolic excursion emerged as risk stratifiers that await external validation but may assist clinicians determining the prognosis of children with PAH.
An Empirical Survey of Data Augmentation for Limited Data Learning in NLP
Authors: Chen Jiaao , Tam Derek , Raffel Colin , Bansal Mohit , Yang Diyi 
Published: March 2023

AbstractNLP has achieved great progress in the past decade through the use of neural models and large labeled datasets. The dependence on abundant data prevents NLP models from being applied to low-resource settings or novel tasks where significant time, money, or expertise is required to label massive amounts of textual data. Recently, data augmentation methods have been explored as a means of improving data efficiency in NLP. To date, there has been no systematic empirical overview of data augmentation for NLP in the limited labeled data setting, making it difficult to understand which methods work in which settings. In this paper, we provide an empirical survey of recent progress on data augmentation for NLP in the limited labeled data setting, summarizing the landscape of methods (including token-level augmentations, sentence-level augmentations, adversarial augmentations, and hidden-space augmentations) and carrying out experiments on 11 datasets covering topics/news classification, inference tasks, paraphrasing tasks, and single-sentence tasks. Based on the results, we draw several conclusions to help practitioners choose appropriate augmentations in different settings and discuss the current challenges and future directions for limited data learning in NLP.
Bureaucratic Acquiescence as an Institutional Strategy in the African Union
Authors: Iroulo Lynda Chinenye , Boateng Oheneba A. 
Published: March 2023

Abstract
The paper conceptualizes acquiescence as a strategy bureaucrats adopt to deal with contestation between themselves and political leaders. The literature on bureaucratic politics argues that policy outcomes result from a game of bargaining between bureaucrats and political leaders. These actors employ diverse strategies like bargaining for more authority, exploiting loopholes, challenging the political class, and, at other times, using the threat of resignation to implement their preferred priorities. However, we advance the above argument by introducing another strategy that bureaucrats use, acquiescence. We analyze African Union (AU) bureaucratic politics through speeches, press releases, and secondary materials. The paper argues that rather than opting for standard bureaucratic strategies, AU bureaucrats acquiesce because the institutional structure, material resources, and the AU solidarity norm make it difficult for them to do otherwise. Acquiescence is the reluctant acceptance of decisions in bureaucratic politics in the form of silence or an absence of protest. We show examples of AU institutional reform and the Burundi crisis debates, where acquiescence can explain decision-making outcomes in the organization. We conclude that acquiescence is a relevant conceptual tool in explaining the outcomes of bureaucratic politics in the AU and can be generalized to investigate institutional politics in other international organizations within and outside of the continent.
Hollow Ways near Tanais
Authors: Garbuzov Gennady P. , Tolochko Irina V. 
Published: March 2023

Abstract
Two ancient roads have been revealed with the help of remote sensing data near Tanais, ancient Greek city in Southern Russia. These roads belong to the class of hollow ways which are often found in the vicinities of Greek settlements in the Northern Black Sea region. Very alike hollow ways were discovered in space photographs around the Bronze Age settlements in Upper Mesopotamia. It is assumed that the mechanisms for the formation of such roads both in the Northern Black Sea region and in Upper Mesopotamia are similar. The development of hollow ways is mainly associated with certain environmental conditions and a special economic model.
Long Knives of the Scythian Culture: Tool or Weapon?
Authors: Shelekhan Oleksandr 
Published: March 2023

Abstract
The article examines Scythian long knives that are similar in length to double-edged daggers. Critically analysing the hypothesis which interprets these items as weapons, it shows that the difference between a fighting knife and utilitarian knife consists not in their measurements, but in their constructive features.
In particular, long knives have much slimmer proportions, unlike daggers. They have neither cross guards nor pommels. This study is concerned with both flat full-metal knives and knives with a short tang. Considering those knives with a partial tang, even the longest ones looks less durable when compared with samples truly designed for combat, as the construction was not intended for heavy strikes. As a result, only full-metal specimens with organic plates on the hilt are here interpreted as weapons. They are similar to those finds from the Northern Balkan region and their morphological features allow us to consider them to be much like daggers.
One can suppose that some of the long knives could have been used in ritual proceedings, during feasts or sacrificial offerings. In some cases, it is also possible to consider long knives as a symbolic alternative to the weapon in the burial inventory. At the same time, it is clear that long knives were in use mostly as utilitarian tools.
The difference in morphology between the Archaic and Classical knives shows the variation in the culture of these two periods of the Scythian culture. The spread of the long knives across the Steppe and Forest-Steppe areas also indicates the cultural connections between these regions.
The Most Western Find of a Chinese Mirror with T-shaped Hieroglyphs in Eurasia
Authors: Treister Mikhail , Ravich Irina 
Published: March 2023

Abstract
The paper discusses the find of a Chinese mirror with T-shaped hieroglyphs, dated to the last third of the 5th–the first half of the 4th century BC and originating from a nomadic burial in the Southern Urals. This is not only the oldest find of a mirror of this type outside China, but also the most western find of a mirror of the Warring States Period in Eurasia. The chemical and technological characteristics of the mirror, studied with the help of scanning electron microscopy and metallography, demonstrate that they are close to the data given in the publications of mirrors from China and thus give no grounds for doubting the origin of the mirror.
Boni Gone Bad: Cicero’s Critique of Epicureanism in De Finibus 1 and 2
Authors: Clarke Michelle T. 
Published: March 2023

Abstract
This paper argues that Cicero’s critique of Epicureanism in De finibus is motivated by a concern about its degrading effect on the moral sensibility of Rome’s best men. In place of earlier objections to Epicureanism, which centered on its inability to explain or recommend the virtuous conduct of Roman maiores, De finibus focuses on its inability to do so properly and, more prospectively, to assist boni in the work of maintaining the dignity and respectability of Roman civic life. Responding to optimates like Cassius who claimed that Epicureanism was compatible with Roman politics because it treats virtue as being necessary for pleasure, Cicero holds that instrumentalizing virtue in this way is actually a grave corruption of it. Not only do Epicureans debase politics by reducing it to considerations of utility alone: they also introduce deeper forms of civic confusion by distorting and abusing the very idea of honorableness.
Republicanism in Desperate Times: Cicero’s Critique of Cato’s Stoicism
Authors: Yellin Mark E. 
Published: March 2023

Abstract
This essay examines two articles by Rex Stem about Cicero and Cato: ‘The First Eloquent Stoic and Cato the Younger’ and ‘Cicero as Orator and Political Philosopher: The Value of the Pro Murena for Ciceronian Political Thought’. It places these articles in dialogue and draws upon them to present an overarching argument about Cicero’s critique of Cato’s Stoicism. It also assesses their respective defenses of Roman republicanism, offering counterarguments to Cicero’s critique of Cato and underlining the ways in which the two men were allies.
The Society of the Cincinnati and Exemplarity in Late 18th-Century America
Authors: Kapust Daniel 
Published: March 2023

Abstract
Drawing on Rex Stem’s analysis of exempla, I explore Mercy Otis Warren and John Marshall’s narrations of the Society of the Cincinnati, and Washington’s place within it, to draw out the lessons they sought to impart. Beginning with an exploration of Cincinnatus’ exemplum in antiquity, its relationship to late 18th-century portrayals of Washington, and its invocation in the establishment of the Society of the Cincinnati, I also discuss the exemplum by a prominent critic of the Society of the Cincinnati, Aedanus Burke. I then turn to Warren and Marshall’s accounts of the Cincinnati. I do so with a particular focus on how a single exemplary American – George Washington – is depicted in two different ways, exemplifying two different sets of moral teaching. I conclude by suggesting that Warren, Marshall, and Burke’s battle over the exemplum of Cincinnatus is a battle over the moral ordering of America’s future.