bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of prone positioning and skin damage prevention digital education: the PRONEtect project
Authors: Fourie Anika , Ahtiala Maarit , Black Joyce , Campos Heidi Hevia , Coyer Fiona , Gefen Amit , LeBlanc Kim , Smet Steven , Vollman Kathleen , Walsh Yolanda , Beeckman Dimitri 
Published: September 2023

Objective: The incidence of skin/tissue damage, such as pressure ulcers, remains high in mechanically ventilated patients in the prone position. According to guidelines, critically ill patients with acute respiratory distress syndrome (ARDS) should be prone for at least 12–16 hours to improve oxygenation and decrease mortality. Therefore, educating clinicians on how to reposition and manage the patient safely in a prone position plays a vital role in preventing adverse events. This project aimed to develop accessible online educational content to assist clinicians in safely executing the prone manoeuvre and minimise skin/tissue damage. Method: The development of the educational content was based on: a gap analysis and comprehensive review of available educational resources; evidence-based scientific literature; advice from international experts; and a qualitative study exploring the learning needs of 20 clinicians in Belgium and Sweden between February–August 2022. Results: Volunteer clinicians assisted with the creation of eight simulation videos which were professionally filmed and edited. The interactive videos included the supine-to-prone and prone-to-supine manoeuvres, endotracheal and nasogastric tube securement, eye care, stoma care, protecting high-risk areas from pressure damage, and incontinence-associated dermatitis prevention. A prone positioning protocol, a checklist summarising the key aspects of the protocol, and teaching aids (slide deck for didactic lecturing) were developed and validated by a review of the relevant evidence-based literature and the international expert panel. A website was designed to host the content, with free user access, at www.pronetection.com . Conclusion: Education is one strategy towards prevention of complications of prone positioning. Accessible education could assist clinicians unfamiliar with prone positioning or current clinicians requiring refresher training to safely manage patients in this position.
Mental stress objective screening for workers using urinary neurotransmitters
Authors: Tanabe Kazuhiro , Yokota Asaka 
Published: September 2023

Background
Almost 10% of the population develop depression or anxiety disorder during their lifetime. Considering that people who are exposed to high stress are more likely to develop mental disorders, it is important to detect and remove mental stress before depression or anxiety disorder develops. We aimed to develop an objective screening test that quantifies mental stress in workers so that they can recognize and remove it before the disorder develops.

Methods
We obtained urine specimens from 100 healthy volunteers (49 men and 51 women; age = 48.2 ± 10.8 years) after they received medical checks and answered the Brief Job Stress Questionnaire (BJSQ). Participants were divided into high- and low- stress groups according to their total BJSQ scores. We further analyzed six urinary neurotransmitters (dopamine, serotonin, 5-hydoroxyindoleacetic acid, gamma-aminobutyric acid, homovanillic acid, and vanillylmandelic acid) using liquid chromatography-mass spectrometry to compare their levels between the two groups.

Results
We obtained the concentrations of the six analytes from 100 examinees and revealed that the levels of urinary dopamine (p = 0.0042) and homovanillic acid (p = 0.020) were significantly lower in the high-stress group than those in the low-stress group. No biases were observed between the two groups in 36 laboratory items. The stress index generated from the six neurotransmitter concentrations recognized high-stress group significantly. Moreover, we discovered that the level of each urinary neurotransmitter changed depending on various stress factors, such as dissatisfaction, physical fatigue, stomach and intestine problems, poor appetite, poor working environments, sleep disturbance, isolation, worry, or insecurity.

Conclusion
We revealed that urinary neurotransmitters could be a promising indicator to determine underlying mental stress. This study provides clues for scientists to develop a screening test not only for workers but also for patients with depression.
Predictors of missed HIV screening opportunities among newly diagnosed individuals at an urban medical center in New York City, 2018–2022
Authors: Paer Jeffrey , Ratcliffe Judy , Chang Michelle , Carnevale Caroline , Quigee Daniela , Gordon Peter , Olender Susan , Sobieszczyk Magdalena E. , Zucker Jason 
Published: September 2023

Objective
To identify demographic and clinical factors predictive of having a missed opportunity (MO) for HIV screening.

Design
Retrospective cohort study.

Methods
Electronic medical records were queried for individuals newly diagnosed with HIV in different sites within a large urban academic medical center in New York City between 2018 and 2022. The primary outcome was having one or more MO for HIV screening within the institution, defined as any encounter at which screening was not performed in the 365 days preceding the HIV diagnosis.

Results
Over one third of new diagnoses had at least one MO in the preceding year. Older individuals, cisgender women and those assigned female sex at birth, and heterosexual individuals were more likely to have at least one MO. An initial CD4 < 200 cells/ul was more likely among men who have sex with women specifically. Most MOs occurred in the emergency department and outpatient settings, with minimal HIV prevention discussions documented during each MO.

Conclusions
These findings suggest that populations perceived to be at lower risk for HIV are more likely to have MOs and possibly late diagnoses, and that universal HIV screening must be implemented into the workflows of emergency department and outpatient settings to facilitate early diagnosis and reduce the incidence of HIV.
Relationships of internet gaming engagement, history, and maladaptive cognitions and adolescent internet gaming disorder: A cross-sectional study
Authors: Wang Xin , Liu Yishen , Chu Harry Kwan-ching , Wong Samuel Yeung-shan , Yang Xue 
Published: September 2023

Objective
This study tested the mediation effect of maladaptive cognition of internet gaming and moderation effect of internet gaming history in the relationship between internet gaming engagement and internet gaming disorder in adolescents.

Method
A total of 2,902 secondary school students were surveyed in Hong Kong from February 2021 to December 2021. The proposed moderated mediation model was tested by PROCESS.

Results
Internet gaming engagement, internet gaming history and maladaptive cognition were positively associated with internet gaming disorder symptoms. Maladaptive cognition significantly mediated the association between internet gaming engagement and internet gaming disorder symptoms in both males and females. In addition, a significant interaction between internet gaming engagement and internet gaming history was detected among females but not for males, namely, the positive relationships of internet gaming engagement with maladaptive cognition and internet gaming disorder symptoms were weaker with the increased years of internet gaming.

Conclusions
Our study provides a better understanding of the underlying mechanism and boundary condition in the association between internet gaming engagement and internet gaming disorder among adolescents. Preventing interventions should aim to reduce maladaptive cognition and internet gaming engagement. Interventions targeting internet gaming engagement maybe more effective among female gamers who are beginners and all male gamers.
The association between depression and addictive social media use during the COVID-19 pandemic: The mediating role of sense of control
Authors: Vally Zahir , Helmy Mai , Fourie Louis 
Published: September 2023

Background
COVID-19 precipitated a plethora of mental health difficulties, particularly for those with pre-existing mental health concerns such as depression or addictive tendencies. For some, the distress that emanated from the experience of the pandemic prompted excessive engagement in the safety of online interactions on social media. The present study examined whether variation in individuals’ sense of control explained the association between depression and addictive social media use.

Method
A sample of 1322 participants from two Middle Eastern nations provided data collected during the peak of the pandemic from February to May 2021. A combination of convenience and snowball sampling were used to recruit and collect data from college-aged students enrolled at two universities in Egypt and the United Arab Emirates, respectively. This study adopted a cross-sectional design in which participants completed a self-administered survey that consisted of measures that assessed depressive affect, sense of control, and addictive social media use.

Results
Depression was significantly and positively associated with addictive SMU. Sense of control was negatively related to both depression and SMU and significantly mediated the association between these two variables (β = .62, SE = .03, 95%CI .56, .68).

Conclusion
This study identified a potential protective variable that could be targeted by psychological treatment to ameliorate the potential onset of addictive SMU in individuals with depressive symptoms under conditions of immense psychological distress such as a worldwide pandemic.
Making a Reality: Inclusive Wedding Vendors and Extramarket Morality
Authors: Parkins Ilya , Findlay Rosie 
Published: September 2023

Abstract
This article analyses a series of interviews with queer-positive wedding apparel and style providers. Vendors’ descriptions of their relationships with clients reveal a prioritization of embodied intersubjectivity. We explore vendors’ construction of themselves as providing respite, in the wedding apparel production process, from clients’ repertoire of experiences of exclusion in a hetero- and cisnormative fashion industry. The intercorporeal ethics at work in the relationships between vendors and clients suggests the persistence of what Wendy Brown has called “extramarket morality” inside the wedding attire marketplace.
Communication and academic burnout: The effects of social support and participation in decision-making
Authors: Ivančević Sonja , Maričić Milica , Vlastelica Tamara 
Published: September 2023

AbstractJust as burnout is manifested through changes in behavioural and communication patterns, it is important to examine whether certain aspects of communication can affect student burnout development. Therefore, this study aims to investigate the relationship between communication and academic burnout. To achieve this, the study proposes an integrated model examining the effects of three communication dimensions – support from academic staff, support from colleagues, and participation in decision-making – on four different dimensions of academic burnout, as well as students’ overall burnout. The model is tested using structural equation modelling (SEM) analysis. High coefficients of determination regarding particular burnout dimensions validate the strength of the proposed model. The results show that support from academic staff and support from fellow students significantly and negatively influence academic burnout, and might be instrumental in its reduction. Unexpectedly, participation in decision-making is shown to be positively related to academic burnout.
Reciprocal Teaching as a Cognitive and Metacognitive Strategy in Promoting Saudi University Students’ Reading Comprehension
Authors: Abdelmoati Mohamed Rafik Ahmed 
Published: September 2023

AbstractReciprocal teaching (RT) involves collaborative dialogue between the teacher and students, with the aim of jointly constructing the meaning from a shared text. This study employs RT as a cognitive and metacognitive set of strategies for enhancing students’ reading comprehension and monitoring skills. Thirty-four students were assigned to the RT group for reading instruction, whereas 30 students were assigned to the control group for regular reading instruction. The four RT strategies (predicting, questioning, clarifying, and summarizing) empowered the students to engage in a non-linear approach to comprehend texts and monitor their reading comprehension. They afforded the students the chance to engage in pre-, during-, and post-reading cognitive and metacognitive processes, collaborate with their peers, read with intentionality and focus, and assume shared responsibility for monitoring their advancement in reading comprehension. The students engaged in the scaffolded activities of read-aloud, dialogue, structured comprehension, and peer teaching to develop their reading comprehension and monitoring skills. The results showed that the RT group outperformed the control group on the post-test in both total score of reading comprehension and individual reading skills. Therefore, language instructors are recommended to use an array of effective RT strategies to enhance their students’ reading comprehension and monitoring skills.
The Zika virus infection remodels the expression of the synaptotagmin-9 secretory protein
Authors: Leiva Santiago , Cantoia Alejo , Fabbri Cintia , Bugnon Valdano Marina , Luppo Victoria , Morales María Alejandra , Rosano Germán , Gardiol Daniela 
Published: September 2023

Abstract
The exact mechanisms involved in flaviviruses virions’ release and the specific secretion of viral proteins, such as the Non Structural protein-1 (NS1), are still unclear. While these processes might involve vesicular transport to the cell membrane, NS1 from some flaviviruses was shown to participate in viral assembly and release. Here, we assessed the effect of the Zika virus (ZIKV) NS1 expression on the cellular proteome to identify trafficking-related targets that may be altered in the presence of the viral protein. We detected an increase in the synaptotagmin-9 (SYT9) secretory protein, which participates in the intracellular transport of protein-laden vesicles. We confirmed the effect of NS1 on SYT9 levels by transfection models while also detecting a significant subcellular redistribution of SYT9. We found that ZIKV prM-Env proteins, required for the viral particle release, also increased SYT9 levels and changed its localization. Finally, we demonstrated that ZIKV cellular infection raises SYT9 levels and promotes changes in its subcellular localization, together with a co-distribution with both Env and NS1. Altogether, the data suggest SYT9’s implication in the vesicular transport of viral proteins or virions during ZIKV infection, showing for the first time the association of synaptotagmins with the flavivirus’ life cycle.
Promoting the formation of environmental awareness in children: the representation of nature in Chinese language textbooks
Authors: Ma Jingxue 
Published: September 2023

Abstract
The main purpose of this study is to investigate the integration of environmental education into language education. Drawing inspiration from Systemic Functional Linguistics (SFL), our focus lies on examining the kinds of participants in material processes in texts carefully chosen from a collection of widely utilized primary school Chinese language textbooks. We pay particular attention to the power and activity hierarchy of participants, to understand how these texts represent nature and the interconnections between fundamental elements in nature. Our findings reveal that these textbooks, through age-appropriate content, are deliberately crafted to instill environmental knowledge in young learners, nurture their ecological awareness and inspire actions aimed at safeguarding the delicate ecosystems that sustain all life forms.
Electrochemical, mechanical, and antibacterial properties of the AZ91 Mg alloy by hybrid and layered hydroxyapatite and tantalum oxide sol–gel coating
Authors: Albayrak Sevda , Gül Canser , Emin Nuray , Gökmen Uğur , Karakoç Halil , Uzun Arif , Çinici Hanifi 
Published: September 2023

Abstract
The corrosion and bacterial behavior of AZ91 magnesium alloy coated with sol–gel-deposited amorphous tantalum oxide and hydroxyapatite have been investigated. The objective was to assess the potential suitability of AZ91 for permanent prosthesis applications. The coatings were applied in layered and hybrid configurations and characterized using various techniques including X-ray diffractometry, Fourier transform infrared spectroscopy, scanning electron microscopy/energy dispersive spectrometry, and drop analyses. The antibacterial properties were evaluated through interactions with Staphylococcus aureus and Escherichia coli strains. Mechanical properties and adhesion were determined via linear scratch tests, and electrochemical corrosion tests were conducted in different media. The release of aluminum ions from the samples in Dulbecco’s Modified Eagle’s Medium was monitored over 28 days. The findings revealed that the amorphous tantalum oxide coating, particularly in combination with hydroxyapatite, improved antibacterial properties and positively influenced corrosion and scratch resistance. The layered and hybrid coatings demonstrated the highest corrosion resistance. The release of aluminum ions remained within acceptable levels in the tested medium. Overall, the study provides valuable insights into the potential of sol–gel coatings on AZ91 for prosthetic applications, considering antibacterial behavior, corrosion resistance, and aluminum release.
Crystal structure of catena-poly[(μ
2-1,4-di(pyridin-4-yl)benzene-κ
2
N:N′)-(4-bromobenzoate-κ
2
O:O′)-(μ-2-bromobenzoate-κ
2
O,O′)nickel(II)] – water (2/1), C30H21Br2N2NiO4.5
Authors: Bao Xiaobo , Tian Chongchong 
Published: September 2023

Abstract
C30H21Br2N2NiO4.5, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.7895(17) Å, b = 13.167(3) Å, c = 14.067(3) Å, α = 109.049(3)°, β = 92.619(3)°, γ = 108.533(3)°, V = 1438.6(5) Å3, Z = 2, R

gt
(F) = 0.0496, wR

ref
(F
2) = 0.1003, T = 296(2) K.
Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins
Authors: Plaidy Pauline , Bouattour Yassine , Yessaad Mouloud , Sautou Valérie , Chennell Philip 
Published: September 2023

Abstract

Objectives
Ceftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The objective of this work was to compare the stability during 168 days of frozen storage of two formulations combining VA and CZ at a final concentration of 25 mg/mL: a CD-free formulation, at a pH=8.5 and a formulation with CD.

Methods
Beforehand, a stability indicating method (SIM) was developed. Samples were analysed after 1, 3 and 6 months, and after 12, 24 and 72 h after defrosting. Analyses performed were the following: visual inspection, chromaticity, turbidity, osmolality and pH measurements, particles counting, CZ and VM quantification, breakdown product research, and sterility assay.

Results
The developed SIM allowed the simultaneous quantification and breakdown products research of both VM and CZ, without interference of the breakdown products. The analyses showed the presence of a visually detectable precipitate and increased turbidity as early as the first day after thawing for CD-free formulation and on the third day for the formulation with CD. CZ concentrations systematically decreased after thawing for both formulations whilst VM concentrations remained stable. Osmolality and pH remained unchanged, and no microbial growth was detected throughout the study.

Conclusions
CD delayed precipitation by 48 h compared to the CD-free formulation but did not permanently eliminate it. Both formulations showed very limited physicochemical stability after thawing.
Brain functional connectivity and network characteristics changes after vagus nerve stimulation in patients with refractory epilepsy
Authors: Ding Yongqiang , Guo Kunlin , Wang Xinjun , Chen Mingming , Li Xinxiao , Wu Yuehui 
Published: September 2023

Abstract

Objective
This study aims to investigate the impact of vagus nerve stimulation (VNS) on the connectivity and small-world metrics of brain functional networks during seizure periods.

Methods
Ten refractory epilepsy patients underwent video encephalographic monitoring before and after VNS treatment. The 2-min electroencephalogram segment containing the ictal was selected for each participant, resulting in a total of 20 min of seizure data. The weighted phase lag index (wPLI) and small-world metrics were calculated for the whole frequency band and different frequency bands (delta, theta, alpha, beta, and gamma). Finally, the relevant metrics were statistically analyzed, and the false discovery rate was used to correct for differences after multiple comparisons.

Results
In the whole band, the wPLI was notably enhanced, and the network metrics, including degree (D), clustering coefficient (CC), and global efficiency (GE), increased, while characteristic path length (CPL) decreased (P < 0.01). In different frequency bands, the wPLI between the parieto-occipital and frontal regions was significantly strengthened in the delta and beta bands, while the wPLI within the frontal region and between the frontal and parieto-occipital regions were significantly reduced in the beta and gamma bands (P < 0.01). In the low-frequency band (<13 Hz), the small-world metrics demonstrated significantly increased CC, D, and GE, with a significantly decreased CPL, indicating a more efficient network organization. In contrast, in the gamma band, the GE decreased, and the CPL increased, suggesting a shift toward less efficient network organization.

Conclusion
VNS treatment can significantly change the wPLI and small-world metrics. These findings contribute to a deeper understanding of the impact of VNS therapy on brain networks and provide objective indicators for evaluating the efficacy of VNS.