bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy, safety, and subjective experience based on ePRO in HIV-infected individuals administered bicetivir, entatabine, and propofol tenofovir in southwest China
Authors: Kong Linghong , Xie Xiaoxin , Fu Yanhua , Gan Lin , Yang Xiaoyan , Ma Shujing , Long Hai 
Published: April 2023

Abstract
Background: Prospective studies examining long-term therapeutic outcomes of the BIC+FTC+TAF regimen in human immunodeficiency virus (HIV) infection remain limited. This study assessed the actual efficacy and safety of BIC+FTC+TAF in HIV-infected individuals in southwest China.
Methods: This was a single-center, prospective study enrolling treatment-naïve (n=32) and treatment-experienced (n=177) HIV-infected patients administered BIC+FTC+TAF treatment between March 2022 and August 2022. The data were collected until February 28, 2023. Virological reactions and adverse events to the treatment were recorded, and patient subjective feelings in the form of ePRO were collected. The primary endpoint was the rate of patients with HIV viral load <50 copies/mL at week 24.
Results: At week 24, 87.5% and 95.5% of treatment-naïve and treatment-experienced HIV patients had a viral load <50 copies/mL, respectively. CD4 cell counts in treatment-naïve and treatment-experienced patients increased significantly by 163.5 cells/μL (P=0.002) and 55.0 cells/μL (P=0.022), respectively. By week 24, no patients had discontinued the BIC+FTC+TAF treatment due to adverse events. Based on ePRO data, treatment-naïve and treatment-experienced patients at week 24 had stable disease symptom burden, quality of life, and depression level after treatment with BIC+FTC+TAF.
Conclusion: BIC+FTC+TAF reduces the viral load in treatment-naïve patients with high viral load as well as treatment-experienced patients with residual viremia. The patient's subjective experience was maintained stable after treatment with BIC+FTC+TAF. This study also revealed a very low incidence for BIC+FTC+TAF drug-related side effects.
Inhibition of cellular factor TM6SF2 suppresses secretion pathways of Hepatitis B, Hepatitis C and Hepatitis D viruses
Authors: Tu Thomas , Ajoyan Harout , Umami Rifqiyah nur , Veeraraghavan Vaishnavi , Najim Mustafa Ahmed M , Khan Anis , Bayoumi Ali , Ho Vikki , Eslam Mohammed , Berg Thomas , Chan Henry L Y , George Jacob , Douglas Mark W 
Published: April 2023

Abstract
Introduction Chronic viral hepatitis, a leading cause of global deaths, is caused by three enveloped viruses from distinct families: hepatitis B virus, hepatitis C virus, and hepatitis D virus (HBV, HCV, and HDV). Despite having different replication strategies, all three viruses rely on secretion through the host endoplasmic reticulum-Golgi pathway to maintain chronic infection. Thus, targeting key genes in this pathway offers the potential for pan-viral therapies to treat chronic hepatitis.
Methods Transmembrane 6 superfamily member 2 (TM6SF2) was knocked down using siRNA in cell culture models of HBV, HCV and HDV and virus secretion was measured. The effect of TM6SF2 polymorphisms on virus blood markers was examined in a cohort of people with hepatitis B.
Results Knockdown of TM6SF2 in cell culture models reduced secretion of infectious HCV virions, HDV virions and HBV subviral particles. Moreover, we show that a TM6SF2 polymorphism (rs58542926 CT/TT, which causes protein misfolding and reduced TM6SF2 in the liver) correlates with lower concentrations of subviral particles in blood from people with hepatitis B, complementing our previous work showing decreased HCV viral load.
Conclusions The host protein TM6SF2 is a novel drug target due to its key role in secretion of HBV, HCV and HDV. This provides the exciting potential for pan-viral agents to treat all people with chronic viral hepatitis.
The need to account for Argos Doppler errors when estimating habitat use from Argos Doppler locations: evidence and solution
Authors: Karagicheva Julia , Linscott Jennifer , Piersma Theunis , Hooijmeijer Jos C.E.W. , Howison Ruth A. , Loonstra A.H. Jelle , Senner Nathan R. , Verhoeven Mo A. , Rakhimberdiev Eldar 
Published: April 2023

Abstract

Background. Due to the large errors in Argos Doppler location estimates, Argos-based satellite transmitter data are rarely used in studies of fine-scale habitat selection by animals. Novel state-space models (SSMs) for path reconstruction from animal movement data improve location estimates, delivering refined estimations of an animal’s most likely path and, also, re-estimating the uncertainties for each location. However, the SSM-refined uncertainties are still relatively large and the true locations of animals tracked with PTTs (Platform terminal transmitters) remain impossible to determine. We suggest an approach that uses the SSM-refined location uncertainties to quantify the probabilities of an animal’s occurrence in each habitat and infer which of the habitats it most likely visited.Methods. We test the performance of our approach against habitat use assays based on most likely locations from raw Argos Doppler estimates and Argos Doppler estimates refined with an SSM. For this, we combine a GPS tracking dataset (2214 location fixes) from one individual and an Argos-PTT tracking dataset (1708 location points) from 14 individual Continental Black-tailed Godwits (Limosa limosa limosa) breeding in agricultural grasslands in The Netherlands utilizing both simulations and empirical data to assess habitat use.Results. The approach that accounted for location uncertainties on top of a state-space model improved habitat assignments in the simulation study by 5% compared with only the SSM-refined Argos location points and by 23% compared with the raw Argos locations. We provide working code in R that can be reproduced for the analysis of habitat selection of animals followed with PTTs.Conclusions. Low-precision tracking data may be suitable to study habitat selection if location uncertainties are taken into account. The approach presented here has the potential to considerably improve the validity of such analyses, opening up new opportunities for the use of Argos Doppler data in analyses of habitat selection by animals. Since Argos Doppler location uncertainty parameters are required for the inference of the most likely used habitat, it is crucial that users acquire this information from Collecte Localisation Satellites (CLS) when initiating a new study.
Neurovascular Coupling During Auditory Stimulation: Event-related Potentials and Fnirs Hemodynamic
Authors: Muñoz Vanesa , Muñoz-Caracuel Manuel , Angulo-Ruiz Brenda Y. , Gómez Carlos M. 
Published: April 2023

Abstract
Intensity Dependent Amplitude Changes (IDAP) have been extensively studied using Event-Related Potentials (ERPs) and have been linked to several psychiatric disorders. This study aimed to explore the application of functional near-infrared spectroscopy (fNIRS) in IDAP paradigms and to relate it to ERPs. Thirty-three and thirty-one subjects participated in two experiments, respectively. The first experiment consisted of the presentation of three-tone intensities (77.9dB, 84.5dB, and 89.5dB) lasting 500 ms, each type randomly presented 54 times, while the second experiment consisted of the presentation of five-tone intensities (70.9dB, 77.9dB, 84.5dB, 89.5dB, and 95.5dB) in blocks composed of eight tones of the same intensity lasting 70 ms each one, in total 20 blocks were presented. EEG was used to measure ERP components: N1, P2, and N1-P2 peak-to-peak amplitude. fNIRS allowed the analysis of the hemodynamic activity in the auditory and prefrontal cortices. The results showed an increase in N1, P2, and N1-P2 peak-to-peak amplitude with auditory intensity. Similarly, oxyhemoglobin and deoxyhemoglobin concentrations showed amplitude increases and decreases, respectively, with auditory intensity in the auditory and prefrontal cortices. Spearman correlation analysis showed a relationship between the left auditory cortex and N1 and the right dorsolateral cortex and P2 amplitude. These results suggest that there is a brain response to auditory intensity changes that can be obtained by EEG and fNIRS, supporting the neurovascular coupling process. Overall, this study contributes to the understanding and application of fNIRS in auditory paradigms and highlights its potential to be used in a complementary manner to ERPs.
A Pan-cancer Analysis of the Role of the Transmembrane Protein 91(TMEM91) in Human Tumors
Authors: Jiang Ziqing , Song Tao , Li Qianying 
Published: April 2023

Abstract
Transmembrane protein 91(TMEM91) encodes a protein belonging to the transmembrane protein family which mediates many human physiological processes, such as the regulation of cell migration and invasion, and participates in the immune response. At present, research on the TMEM family members focuses mostly on the field of molecular mechanisms, and the role of TMEM91 in tumor cells is still unrecognized. Using data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, we can analysis the expression of TMEM91 in various tumors. The Kaplan-Meier method was used for the evaluation of the prognostic significance of TMEM91 in patients with pan-cancer. The dif-ferential expression of TMEM91 in diverse cancers with different clinical characteristics was analyzed with the UALCAN database. TIMER was used to explore how TMEM91 correlates with immune infiltration. The correlations between TMEM91 expression immune checkpoint (ICP), tumor mutational burden (TMB), and microsatellite instability (MSI) in human cancers were analyzed via the SangerBox database. Gene Set Cancer Analysis (GSCA) platform was used to investigate the correlation between TMEM91 expression with Copy number variations (CNV) and methylation. Protein-Protein Interaction analysis was performed in the GeneMANIA database. Gene Ontology and Kyoto Encyclopedia of Genes pathway en-richment analyses were further conducted for exploration of TMEM91 function. According to the finding of this study, downregulated TMEM91 expression was observed in numerous tumor tissues. The low TMEM91 expression group showed poor overall survival (OS) and disease-free survival (DFS). TMEM91 was positively correlated with can-cer-associated fibroblast (CAF), and nature killer T cell (NKT), and negatively correlated with CD4 + T cells, B cells and common lymphoid progenitor (CLP). Here, we show that there is a positive relationship between Contingent Negative Variation (CNV) and expression of TMEM91, whereas the correlation of TMEM91 expression with DNA methylation was nega-tive in all cases. Molecular biology experiments were performed to confirm the tumor pro-moting role of TMEM91 in glioma. Function analysis showed that TMEM91 expres-sion-related genes were mainly enriched in response to type I interferon /regulation of viral genome replication/negative regulation of viral process/movement in host environment. In addition, the association between the expression of TMEM91 and the use of the anticancer drug, sensitive anti-tumor drug based on CellMiner were predicted, such as the anticancer drug AS-703569, Hydroxyurea. Our pan-cancer analysis provides a deep understanding of the functions of TMEM91.TMEM91 may affect the oncogenesis and metastasis in different cancers via mediating the immune infiltrating cells and the degree of methylation. This study sheds new light on the mechanism of TMEM family in cancer.
Preparation and properties of a novel decorative base paper for formaldehyde-free adhesive impregnation
Authors: Liang Min , Gong Jingya , Xu Jianfeng , Liu Ru , Long Ling 
Published: April 2023

Abstract
Formaldehyde-free adhesives are gaining attention due to their compatibility with green production methods. Decorative base paper (DBP) is known for its physical strength and printability and has a high ability for absorbing aldehyde-free adhesives for impregnation. In this paper, DBP was prepared with TiO2 and SiO2 combined with polyvinyl alcohol (PVA), where the amount of TiO2 was reduced in the pulp process. The prepared DBP was impregnated by aldehyde-free adhesive and hot-pressed on wood-based panels. The results showed that upon SiO2 coating, the surface smoothness of base paper increased by 132.3%, whereas the tensile strength increased by 33.6%. Furthermore, the color density of cyan, magenta, yellow and black colors increased by 75.4%, 99.2%, 51.9% and 90.5%, respectively. The surface properties like surface bonding strength and wear resistance of the covered wood-based panels were found to satisfy the standard requirements, which indicates the products can be used for furniture products.
Clinical utility and applicability of the ,Esophagus Complication Consensus Group’ (ECCG) classification of anastomotic leakage following hybrid Ivor-Lewis esophagectomy
Authors: Bartella Isabel , Brunner Stefanie , Schiffmann Lars M. , Schiller Petra , Schmidt Thomas , Fuchs Hans , Chon Seung , Bruns Christiane Josephine , Schröder Wolfgang 
Published: April 2023

Abstract
Purpose Anastomotic leakage (AL) remains the leading surgical complication following Ivor-Lewis (IL) esophagectomy. Different treatment options of AL exist but outcome is difficult to compare due to a lack of generally accepted classifications. This study was conducted to analyze the clinical significance of a recently proposed classification based on the management of AL.Methods A cohort of 954 consecutive patients undergoing hybrid IL esophagectomy (laparoscopy/thoracotomy) was analysed. AL was defined according to the ,Esophagus Complication Consensus Group’ (ECCG) criteria depending on its treatment: conservative (AL type I), interventional endoscopic (AL type II), and surgical (AL type III). Primary outcome was single or multiple organ failure (Clavien-Dindo IVA/B) associated with AL.Results Overall morbidity was 63.0% and 8.8% (84/954 patients) developed an AL postoperatively. Three patients (3.5%) had an AL type I, 57 patients (67.9%) an AL type II and 24 patients (28.6%) an AL type III. For patients managed surgically, AL was diagnosed significantly earlier (median days: AL type III: 2 vs AL type II: 6, p < 0.001). Associated organ failure (CD IVA/B) was significantly lower for AL type II as compared to AL type III (21.1% versus 45.8%, p < 0.0001). In-hospital mortality was 3.5% for AL type II and 8.3% for AL type III (p = 0.789). There was no difference for re-admission to ICU and overall length of hospital stay.Conclusion The proposed ECCG classification is simply to apply and discriminates the post-treatment severity of AL but does not aid to implement a treatment algorithm.
Surface Modification of Paper Substrates by A Printed UV Curing Varnish Layer and A Transferred Transparent PEDOT:PSS Electrode for Paper-based Perovskite Light-Emitting Devices in Ambient Air
Authors: Liu Guodong , Gao Xiuan , Wang Yinfeng , Li Zhijian 
Published: April 2023

Abstract
Paper, a low-cost and eco-friendly substrate, can be used to prepare flexible electronic devices by resorting to surface modification technology. In this study, we investigated the surface modification of paper substrates, including those that were uncoated or coated with traditional mineral coatings, to analyze the enhancements to surface flatness and water resistance using a UV curing varnish layer. Furthermore, we explored the formation of perovskite films on the surface-modified paper substrates utilizing a PEO-doped perovskite precursor solution in ambient air, and the surface morphology, crystallinity, photoluminescence properties, and absorption properties of the prepared perovskite films were discussed accordingly. Considering the nontransparent feature of paper-based substrates, the inverted perovskite light-emitting device was finally assembled by transfer printing a transparent PEDOT:PSS layer as a top electrode. The conductive and optical properties of the electrode layer were thus analyzed as well. It is found that the surface modification of paper substrates via printing the UV curing varnish can illustrate significant improvements, such as pore-filling on the surface, a more than 10-fold reduction in roughness, and downward penetration. Moreover, prepared perovskite films on the surface-modified coated paper exhibit superior enhancements, including photoluminescence, higher crystallinity, and surface roughness and porosity. Devices fabricated on the surface-modified substrates are less susceptible to short-circuiting. The electroluminescence improved on the surface-modified coated paper substrate is 2.16 times higher than the prepared device on the surface-modified base paper substrate and even 3.23 times higher than on the PET substrate. Therefore, it is quite feasible to fabricate a perovskite light-emitting device on the modified surface of a paper substrate by using a printed UV curing varnish layer, which is expected to be a promising coating to polish the paper surface in the preparation of electroluminescent devices.
Irregularity and Multifractal Structure of Precipitation Patterns in Europe, the Mediterranean, the Middle East, and North Africa
Authors: TATLI Hasan , KOÇAK Kasım 
Published: April 2023

Abstract
This study proposes a new perspective on analysing precipitation patterns in a large geographic region covering Europe, the Mediterranean, the Middle East, and North Africa. The primary objective is to investigate the multifractal singular spectrum structure of precipitation patterns, which is an important contribution to understanding the complex spatiotemporal variability of precipitation in this region. By using advanced statistical techniques such as multifractal detrended fluctuation analysis (MF-DFA), cross-correlation analysis (MF-DCCA), and empirical orthogonal functions (EOF) on precipitation data from the Climate Prediction Centre’s Combined Precipitation Analysis (CMAP), this study aims to enhance our understanding of precipitation patterns in the region and provide valuable insights into their multifractal singular spectrum structure. The DCCA technique was used to analyse the EOF functions of precipitation time series in the 12-month, 60-month (5-year), and 120-month (10-year) moving-window periods. In addition to the EOF patterns of the conventional (Pearson) correlation matrix, 864 precipitation time series from latitudes 20° to 75° N and longitudes 23°W to 61° E were used. The broad research area was chosen to encompass the Mediterranean basin, which is in a transition zone between the semi-arid North African belt and the moist western and central European regions. The present research employed the MF-DFA technique to compute the Hurst exponents and multiple fractal spectra of the top five significant empirical orthogonal functions (EOFs) across the studied region. Overall, this study offers a novel approach to analysing precipitation patterns in this region and can significantly contribute to our knowledge of their multifractal singular spectrum structure. The findings show that minor-scale fluctuations have a greater impact on the fixed larger-scale components, as evidenced by the q-dependent multifractal singular spectrum of the Hurst exponents. This could account for the non-uniform fractal shape and positively skewed inclination of the probability density functions of the precipitation data. The study reveals that the multifractal q-dependent structure of the EOFs remains persistent up to the 12th month or sub-year, after which it disappears. This observation is consistent with the finding that the EOF patterns, which provide insights into the geographical distribution of precipitation, are generally preserved over intervals of 12 months or more. Thus, the analysis of precipitation records across a large region highlights a prevalent climatological pattern that varies and evolves at sub-year intervals but is more stable and essentially consistent over longer timescales.
Research on similar time series data search algorithm based on dimension-by-dimension strategy
Authors: Wang Dacheng , Teng Qizhi , Jiao Yue , Zhang Ling 
Published: April 2023

Abstract
The CS search algorithm is a new type of bionic optimization algorithm, which is simple and efficient, and has been successfully used in classical theoretical research and engineering applications. The algorithm uses the overall update evaluation solution to solve the continuous function optimization problem. Due to the phenomenon of mutual dimensional interference, the local refinement ability and convergence speed of the algorithm will be affected to some extent. This paper introduces the evaluation strategy of one-dimensional update and rewrites the step formula of the random walk component so that the algorithm makes full use of one-dimensional evolution information. It strengthens the local search, improves the convergence speed and the quality of the solution, and gives experimental results. The calculation results of different dimensions show that: as the dimension increases, the dimension-by-dimension strategy improves the convergence speed and solution quality. Compared with the related improved CS algorithm and other evolutionary algorithms, the improved algorithm has certain competitiveness in solving multi-dimensional function optimization problems.
Tool State Recognition During Milling Process using Time Series Signals and Multiple Input CNN Architecture.
Authors: Bukowski Michał , Antoniuk Izabella , Szymanowski Karol , Kurek Jarosław 
Published: April 2023

Abstract
This paper presents a novel multi-input Convolutional Neural Network (CNN) architecture. Instead of commonly used, single-input variant, described method is based on 11 input images. The resulting machine learning model is applied to the problem of automatic monitoring of tool wear during chipboard milling. The main goal is to inform the machine operator about the degree of tool wear, categorized in three classes as "green," "yellow," or "red", denoting deteriorating state. Each of the initial 75 samples (25 samples per class) consisted of 11 signals. All signals were then represented as scalograms, where each image was created using the continuous wavelet transform (CWT) based on the Morse wavelet. Scalograms provide a visual representation of the signal's behavior in both time and frequency domains, simplifying the analysis and interpretation of its features. Resulting dataset containing scalogram images, consisted of 825 elements, enabling the construction of a reliable milling diagnostic model that recognized the milling tool as one of the three wear classes using the modified 11-input CNN. The advantage of this approach is the elimination of manual extraction of potential diagnostic variables for each signal and feature selection, as CNNs performs this stage without supervision and manual processes. This means that the risk of overfitting the model is reduced, and at the same time stability is increased. The obtained model accuracy surpasses previously analyzed approaches, reaching 96.00% compared to the 93.33% accuracy obtained earlier on.