bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orb2 enables rare-codon-enriched mRNA expression duringDrosophilaneuron differentiation
Authors: Stewart Rebeccah K , Nguyen Patrick , Laederach Alain , Volkan Pelin C , Sawyer Jessica K , Fox Donald T 
Published: July 2023

AbstractRegulation of codon optimality is an increasingly appreciated layer of cell- and tissue-specific protein expression control. Here, we use codon-modified reporters to show that differentiation ofDrosophilaneural stem cells into neurons enables protein expression from rare-codon-enriched genes. From a candidate screen, we identify the cytoplasmic polyadenylation element binding (CPEB) protein Orb2 as a positive regulator of rare-codon-dependent expression in neurons. Using RNA sequencing, we reveal that Orb2-upregulated mRNAs in the brain with abundant Orb2 binding sites have a rare-codon bias. From these Orb2-regulated mRNAs, we demonstrate that rare-codon enrichment is important for expression control and social behavior function of the metabotropic glutamate receptor (mGluR). Our findings reveal a molecular mechanism by which neural stem cell differentiation shifts genetic code regulation to enable critical mRNA and protein expression.
Clinical practice guidelines to prevent hospital falls: protocol for a systematic review
Authors: McKercher Jonathan P. , Peiris Casey L. , Hill Anne-Marie , Morris Meg E. 
Published: July 2023

ABSTRACTBackgroundHospital falls are a major global problem responsible for considerable morbidity, mortality, and healthcare costs. Clinical practice guidelines for hospital falls prevention, facilitate the implementation of falls prevention research into practice, through the provision of evidence-based recommendations to mitigate the risk of falls. The review aims to identify, synthesise, appraise, and compare published clinical practice guidelines on hospital falls prevention.Methods and analysisThe databases of MEDLINE, Embase, CINAHL, Cochrane CENTRAL, PEDro, Web of Science, Infobase of Clinical Practice Guidelines, and Epistemonikos will be searched for clinical practice guidelines published between 1993 and 2023. The quality of the guidelines will be evaluated using the Appraisal of Guidelines for Research and Evaluation Global Rating Scale and Recommendation EXcellence tools. A thematic synthesis will be performed on the content of the included clinical practice guidelines. The synthesis findings will be graded using the Grading of Recommendations Assessment, Development and Evaluation Confidence in Evidence from Reviews of Qualitative Research approach.Ethics and disseminationEthics approval is not required for the review. The review will be submitted for publication to a peer-reviewed journal.
The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics
Authors: Verdys Perrine , Barroso Javier Rey , Vermeil Joseph , Bergert Martin , Sanchez Thibaut , Métais Arnaud , Mangeat Thomas , Bellard Elisabeth , Bigot Claire , Girard Jean-Philippe , Maridonneau-Parini Isabelle , Vérollet Christel , Lagarrigue Frédéric , Diz-Muñoz Alba , Heuvingh Julien , Piel Matthieu , Roure Olivia Du , Cabec Véronique Le , Carréno Sébastien , Poincloux Renaud 
Published: July 2023

AbstractThe cellular actin cortex provides crucial mechanical support and plays critical roles in numerous functions, including cell division and migration. The proteins of the ERM family, ezrin, radixin, and moesin, are central to these processes by linking the plasma membrane to the actin cytoskeleton. To investigate the individual contributions of these three proteins to leukocyte migration, we generated single and triple ERM knock-out macrophages. Surprisingly, we found that even in the absence of ERMs, macrophages can still form the different actin structures promoting cell migration, such as filopodia, lamellipodia, podosomes, and ruffles. Furthermore we discovered that, unlike every other cell type previously investigated, the single or triple knock-out of ERMs does not affect macrophage migration in a large diversity of contexts. Finally, we demonstrated that the loss of ERMs in macrophages does not affect the mechanics of their actin cortex. These findings challenge the notion that ERMs are universally essential for cortex mechanics and cell migration and support the notion that the macrophage cortex may have diverged from that of other cells to allow for their adaptive cortical plasticity.
Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties
Authors: van Genderen Maisa , Kneppers Jeroen , Zaalberg Anniek , Bekers Elise , Bergman Andries M , Zwart Wilbert , Eduati Federica 
Published: July 2023

AbstractInhibiting androgen receptor (AR) signaling through androgen deprivation therapy (ADT) reduces prostate cancer (PCa) growth in virtually all patients, but response is temporary, and resistance inevitably develops, ultimately leading to lethal castration-resistant prostate cancer (CRPC). The tumor microenvironment (TME) plays an important role in the development and progression of PCa. In addition to tumor cells, TME-resident macrophages and fibroblasts express AR and are therefore also affected by ADT. However, the interplay of different TME cell types in the development of CRPC remains largely unexplored.To understand the complex stochastic nature of cell-cell interactions, we created a PCa-specific agent-based model (PCABM) based onin vitrocell proliferation data. PCa cells, fibroblasts, “pro-inflammatory” M1-like and “pro-tumor” M2-like polarized macrophages are modeled as agents from a simple set of validated base assumptions. PCABM allows us to simulate the effect of ADT on the interplay between various prostate TME cell types. The resultingin vitrogrowth patterns mimic human PCa.Our PCABM can effectively model hormonal perturbations by ADT, in which PCABM suggests that CRPC arises in clusters of resistant cells, as is observed in multifocal PCa. In addition, fibroblasts compete for cellular space in the TME while simultaneously creating niches for tumor cells to proliferate in. Finally, PCABM predicts that ADT has immunomodulatory effects on macrophages that may enhance tumor survival. Taken together, these results suggest that AR plays a critical role in the cellular interplay and stochastic interactions in the TME that influence tumor cell behavior and CRPC development.
Electronics manufacturing entrepreneurs in a performance bonsai trap: the case of an emerging economy
Authors: Mishra Brajesh , Kumar Avanish , Mishra Ishaan 
Published: July 2023

PurposeThe study explores the evolution of Indian domestic electronics manufacturing post-economic reforms and also investigates the lack of natural growth stages among Indian start-up/SME electronics manufactures.Design/methodology/approachThe theoretical framework is inspired by Dawar and Frost's survival strategy theory that local companies may follow to overcome competitive threats from MNCs. The study adopts a qualitative methodology, more precisely, a phenomenological approach to walking through policy/regulatory reforms amid market distortions, technological gaps and colonial mindset from the perspective of Indian domestic electronics manufacturers. The study has adopted Gioia method of data analysis to inductively suggest a few research propositions.FindingsThe phenomenological approach revealed eight essential structure (essence) narratives to explore the complex issue that plague the industry: make in India, made in India, preferential market access strategy, equitable market access strategy, blue ocean strategy, competitive positioning strategy, technical capability and importance of policy/regulatory arbitrage.Practical implicationsThe situation of Indian electronics manufacturing units is comparable to the bonsai tree situation, where natural evolution in business stages does not exist; they are born and die as start-ups/MSMEs. The study advocates for equitable market access by removing market distortions. The long-term solution may lie in making available locally manufactured products as a dependable alternative to the imported products or produced locally by MNC OEMs in terms of cost, quality, technology, volume, after-sale service and integrated supply chain.Originality/valueWhile the favorable FDI policies, digital India and make-in India initiatives have strengthened domestic electronics production, it is yet to significantly impact India's position in global trade, including manufacturing and exports.
The contagious effect of economic policy uncertainty in the post-crisis period
Authors: Seker Onur 
Published: July 2023

PurposeThis study aims to analyze the contagious effects of economic policy uncertainties in the USA on the economies of its important trading partners, such as Japan, Canada, Mexico and the Eurozone.Design/methodology/approachIn the study using the uncertainty index created by Baker et al. (2016), the interaction between variables was analyzed with structural VAR (SVAR) models.FindingsAccording to the results obtained from the analysis, economic policy uncertainties in the USA had significant effects on the economies of its high-volume trading partners. The internal debt crisis experienced in the Eurozone after the 2008 crisis caused the European Central Bank to respond to the economic policy uncertainties in the USA with contractionary monetary policies, unlike other countries. In addition to these results, Mexico, which has a more fragile economic structure than other countries in the analysis, was more impacted by increasing uncertainties, as expected.Originality/valueThe present study aimed to bring a new perspective to the literature by evaluating the contagiousness of local uncertainty in the globalizing world and the monetary policies implemented as a precaution against this situation on an empirical plane.
The effect of small-scale changes in wealth on risk attitudes: an experimental study
Authors: Almeida Sergio 
Published: July 2023

PurposeThis study aims to examine the effects of prior small-scale changes to wealth on subsequent risky choices.Design/methodology/approachThe paper opted for a laboratory experiment in which subjects perform two sequences of risky tasks. In between these two sets, the author transfers money for real for a randomly selected half of the subjects. Data on choices before and after the transfer of money are used to estimate risk attitudes and analyze whether the transfer of money affected attitudes to risk.FindingsThe author finds that the money gain does not change subjects' risk preferences – neither in a within- nor in a between-subject design. This suggests that individuals' risky choices are consistent with their constant absolute (CARA) risk aversion preferences, a result that supports a key assumption in recent literature on the calibration critique of decision theories and the view that individuals engage in narrow framing.Research limitations/implicationsBecause of the relatively small transfer of money, the research results may lack generalizability.Practical implicationsThe paper includes implications for the reference-dependent and other theories that explain how prior outcomes affect risk-taking behavior in sequential problems.Social implications The results are relevant to the research community studying risk-taking behavior as the results shed new light on a well-known result put forward by a seminal paper by Thaler.Originality/valueThis paper fills in an identified gap in the literature which is the need to test the house-money effect in a more realistic setting (over repeated risk-elicitation tasks, with money given outside the lotteries and in a within-subject design).
IoT-based entrepreneurial opportunities in smart transportation: a multidimensional framework
Authors: Jami Pour Mona , Hosseinzadeh Mahnaz , Moradi Maryam 
Published: July 2023

PurposeThe Internet of Things (IoT), as one of the new digital technologies, has created wide applications in various industries, and one of the most influential industries of this technology is the transportation industry. By integrating the IoT with the transportation industry, there will be dramatic changes in the industry, and it will provide many entrepreneurial opportunities for entrepreneurs to develop new businesses. Opportunity identification is at the heart of the entrepreneurial process, and entrepreneurs identify innovative goods or services to enter a new market by identifying, evaluating, and exploiting opportunities. Despite the desire of transportation managers to invest in the IoT and the increase in research in this area, limited research has focused on IoT-based entrepreneurial opportunities in the transportation industry. Therefore, the present study aims to identify IoT-based entrepreneurial opportunities in the transportation industry and examine their importance.Design/methodology/approachTo achieve the research objective, the authors applied a mixed approach. First, adapting the lens of the industry value chain theory, a comprehensive literature review, besides a qualitative approach including semi-structured interviews with experts and thematic analysis, was conducted to identify the entrepreneurial opportunities. The identified opportunities were confirmed in the second stage using a quantitative survey method, including the Student t-test and factor analysis. Finally, the identified opportunities were weighted and ranked using the best worst method (BWM).FindingsEntrepreneurial opportunities are classified into five main categories, including “smart vehicles”, “business partners/smart transportation supply side”, “supporting services”, “infrastructures”, and “smart transport management and control”. The infrastructures group of opportunities ranked the highest amongst the identified groups.Originality/valueThis study adds to the digital entrepreneurship opportunity recognition literature by addressing opportunities in a smart industry propelled by digital technologies, including developing new products or new applications of the available technologies. Additionally, inspired by the industry value chain theory, this article develops a framework including various digital entrepreneurial opportunity networks which are necessary to add value to any industry and, thus, could be applied by entrepreneurs to recognize opportunities for new intermediaries to enter other digital-based industries. Finally, the present study identifies the IoT-based entrepreneurial opportunities in the smart transportation industry and prioritizes them, providing practical insights regarding the creation of entrepreneurial ecosystems in the field of smart transportation for entrepreneurs and policymakers.
Do ICTs reduce inequalities in access to professional training in Cameroon?
Authors: Nzepang Fabrice , Atangana Siméon Serge , Nguenda Anya Saturnin Bertrand 
Published: July 2023

PurposeThis work aims to assess the effects of information and communication technology (ICT) on inequalities in access to professional training (PT) in Cameroon.Design/methodology/approachThis study used data from the fourth Cameroonian Household Survey (ECAM 4), the concentration index (CI) calculations and the Wagstaff et al. (2003) decomposition.FindingsThe preliminary results show that the CI calculations by groups of individuals reveal the existence of significant inequalities in favour of the poor. This is the case for all groups of individuals who use ICT tools, namely radio, internet, telephone and television. The results of the Wagstaff et al. (2003) decomposition reveal that an equitable distribution of income between those who use and those who do not use the telephone, radio and internet reduces inequalities in access to FP in favour of the poor.Originality/valueDespite the wealth of literature devoted to the study of inequalities in access to education, the consideration of PT is still very marginal. In Cameroon, the literature devoted to the study of inequalities in access to PT is still almost non-existent, probably because of a low level of interest in the scientific community. However, as just seen, PT is a tool for combating unemployment, particularly in economies where the informal sector is important, insofar as the proportion of unemployed and inactive people is very low amongst the ones that have taken a PT course. Moreover, studies on the effects of ICT on inequalities in access to PT are still rare in the literature.
Employees' learning behavior in the context of AI collaboration: a perspective on the job demand-control model
Authors: Chen Aihui , Yang Tuo , Ma Jinfeng , Lu Yaobin 
Published: July 2023

PurposeMost studies have focused on the impact of the application of AI on management attributes, management decisions and management ethics. However, how job demand and job control in the context of AI collaboration determine employees' learning process and learning behaviors, as well as how AI collaboration moderates employees' learning process and learning behaviors, remains unknown. To answer these questions, the authors adopted a Job Demand-Control (JDC) model to explore the influencing factors of employee's individual learning behavior.Design/methodology/approachThis study used questionnaire survey in organizations using AI to collect data. Partial least squares (PLS) predict algorithm and SPSS were used to test the hypotheses.FindingsJob demand and job control positively influence self-efficacy, self-efficacy positively influences learning goal orientation and learning goal orientation positively influences learning behavior. Learning goal orientation plays a mediating role between self-efficacy and learning behavior. Meanwhile, collaboration with AI positively moderates the impact of employees' job demand on self-efficacy and the impact of self-efficacy on learning behavior.Originality/valueThis study introduces self-efficacy as the outcome of JDC model, demonstrates the mediating role of learning goal orientation and introduces collaborative factors related to artificial intelligence. This study further enriches the theoretical system of human–AI interaction and expands the content of organizational learning theory.
Role of community trust in driving brand loyalty in large online B2B communities
Authors: Sethi Amit Rakesh , Dash Satyabhusan , Mishra Abhishek , Cyr Dianne 
Published: July 2023

Purpose
Online customer communities have become a strategic tool for business-to-business (B2B) firms to drive collaboration among customers around the company’s products and services. This paper aims to argue that the three social capital dimensions, that is, structural, relational and cognitive, themselves driven by brand community trust, can affect brand loyalty for the organization.

Design/methodology/approach
The authors use a survey to collect data and structural equation modeling to test the conceptual framework by collecting data from 214 participants across three online B2B communities operated by three technology firms in India.

Findings
Brand community trust is found to have a strong association with social network ties, identification and norm of reciprocity and shared vision. These three have concomitant effects on the quality of customer-to-customer (C2C) interactions. Such communication generates functional, emotional and social benefits, which, in turn, curate brand loyalty.

Practical implications
The authors’ findings guide community managers in leveraging such conversations in shaping customer loyalty for the corporate brand.

Originality/value
This work provides an integrated framework to explain the important role of C2C interactions in B2B online brand communities.
Changing learning paradigms: an interplay of Digital Taylorism and technostress on perceived employability
Authors: Duggal Harshleen Kaur , Khatri Puja , Thomas Asha , Pironti Marco 
Published: July 2023

Purpose
Massive open online courses (MOOCs), a Taylorist attempt to automate instruction, help make course delivery more efficient, economical and better. As an implementation of Digital Taylorism Implementation (DTI), MOOCs enable individuals to obtain an occupation-oriented education, equipping them with knowledge and skills needed to stay employable. However, learning through online platforms can induce tremendous amounts of technology-related stress in learners such as complexity of platforms and fears of redundancy. Thus, the aim of this paper is to study how student perceptions of DTI and technostress (TS) influence their perceived employability (PE). The role of TS as a mediator between DTI and PE has also been studied.

Design/methodology/approach
Stratified sampling technique has been used to obtain data from 305 students from 6 universities. The effect of DTI and TS on PE, and the role of TS as a mediator, has been examined using the partial least squares (PLS) structural equation modelling approach with SMART PLS 4.0. software. Predictive relevance of the model has been studied using PLSPredict.

Findings
Results indicate that TS completely mediates the relationship between DTI and PE. The model has medium predictive relevance.

Practical implications
Learning outcomes from Digitally Taylored programs can be improved with certain reforms that bring the human touch to online learning.

Originality/value
This study extends Taylorism literature by linking DTI to PE of students via technostress as a mediator.
How source of product acquisition affects consumers' reliance on positive word-of-mouth: a mental imagery perspective
Authors: Chen Chunfeng , Zhang Depeng 
Published: July 2023

PurposeThis research focuses on the role of product acquisition cues in positive word-of-mouth (PWOM) content on social media, comparing the characteristics of different sources of product acquisition (purchased vs. gifted) and exploring whether and how they affect consumers' reliance on word-of-mouth (WOM).Design/methodology/approachThe research model was developed based on the mental imagery theory. Two offline experiments and two online experiments were used to test the proposed hypotheses.FindingsThe results show that, compared to the purchased source, the gifted source evokes more positive mental imagery and greater emotional attachment to the product, resulting in greater consumer reliance on PWOM. In addition, the effect of the source of product acquisition on reliance on PWOM was stronger for experiential (vs. material) products and for consumers with higher interdependent (vs. independent) self-construal.Originality/valueThis research highlights the role of product acquisition cues in PWOM in influencing consumers' evaluation of WOM, while also revealing the processes inherent in how consumers process information through mental imagery. The findings provide a more comprehensive understanding of the antecedents of reliance on WOM and offer new insights and recommendations for management practitioners.