bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and correlates of stress, anxiety, and depression in patients with chronic diseases: a cross-sectional study
Authors: M. Swathi , S. Manjusha , Vadakkiniath Isatrin J. , A. Gururaj 
Published: August 2023

Abstract
Background
Many chronic diseases, including diabetes, heart disease, cancer, and respiratory problems, can lead to emotional distress, anxiety, and depression among patients. Likewise, psychological conditions such as anxiety and depression can elevate the risk of developing chronic diseases. The objective of the study was to examine the prevalence of stress, anxiety, and depression in individuals with chronic diseases, as well as to identify the chronic disease with the highest prevalence among all chronic conditions and the factors associated with stress, anxiety, and depression.

Results
In our study, the prevalence rate of stress, anxiety, and depression in patients having chronic diseases was found to be 68.7%, 51.1%, and 58.8%, respectively. The chronic diseases which are included in this study are cardiovascular diseases, metabolic disorders, cancer, respiratory disorders, degenerative disorders, chronic kidney disease, and chronic liver disorders. Among these diseases, cardiovascular disease patients were found to have the highest prevalence of stress, anxiety, and depression. The psychosocial determinants that can trigger stress, anxiety, and depression were analyzed. The factors like age, marital status, primary caretakers of the patient, social isolation, length of hospital stay, social relationships, number of frequent visits to the hospital/month, and the lifestyle of the patient have a significant association with the levels of stress, anxiety, and depression. Factors like monthly income and educational status were also found to be statistically significant with the stress levels, and length of intensive care unit (ICU) stay was significantly associated with the levels of anxiety.

Conclusion
In conclusion, this study found a high prevalence of stress, anxiety, and depression among patients with chronic disease(s). Among all the chronic diseases, cardiovascular disease patients were found to have the highest prevalence of stress, anxiety, and depression. In addition, our study also identified several psychosocial factors that contribute to the development of these mental health conditions which exacerbate the present chronic condition of the patient. These findings highlight the importance of considering the impact of chronic disease on mental health problems.
Low-dose CT radiomics features-based neural networks predict lymphoma types
Authors: Erturk Hasan , Eser Mehmet Bilgin , Buz Yaşar Aysenur , Ayaz Muzaffer , Atalay Basak , Tatoglu Mehmet Tarık , Caymaz Ismail 
Published: August 2023

Abstract
Background
Fluorodeoxyglucose positron emission tomography (PET)–computed tomography (CT) is preferred for pretreatment staging and treatment planning in patients with lymphoma. This study aims to train and validate the neural networks (NN) for predicting lymphoma types using low-dose CT radiomics.

Results
Few radiomics features were stable in intraclass correlation coefficient and coefficient of variation analysis (n = 119). High collinear ones with variance inflation factor were eliminated (n = 56). Twenty-four features were selected with the least absolute shrinkage and selection operator regression for network training. NN had 75.76% predictive accuracy in the validation set and has 0.73 (95% CI 0.55–0.91) area under the curve (AUC) to differentiate Hodgkin lymphoma from non-Hodgkin lymphoma. NN which was used to differentiate B-cell lymphoma from T-cell lymphoma had 78.79% predictive accuracy and has 0.81 (95% CI 0.63–0.99) AUC.

Conclusions
In this study, in which we used low-dose CT images of PET–CT scans, predictions of the neural network were near acceptable lower bound for Hodgkin and non-Hodgkin lymphoma discrimination, and B-cell and T-cell lymphoma differentiation.
Influencing factors of e-learning adoption amongst students in a developing country: the post-pandemic scenario in Bangladesh
Authors: Maisha Kashfia , Shetu Sabakun Naher 
Published: August 2023

AbstractE-learning is the consequence of the merging of technology and education, and it is now a highly efficient educational medium. Therefore, this study aims to explore the notion of continuous usage of online learning in education. Here, the study examined the key elements influencing whether Bangladeshi university students will continue usage of online learning following the outbreak. It explores a novel setting, extending the UTAUT model and laying the groundwork for upcoming scholars. The UTAUT3 model served as the theoretical foundation for the analysis of the relationship between the components using structural equation modeling. Additionally, this research was conducted as soon as face-to-face education resumed following each pandemic lockdown. According to the study's findings, among the independent variables-performance expectancy, social influence, and behavioral intention were the most important indicators of students' intention to continue use e-learning systems after the COVID-19 pandemic. Moreover, voluntariness of use on social influence was also found to be significant. This is one of the first studies to investigate a new technical service (e-learning services) in the extended framework of UTAUT3 model and gives us an understanding of reasons as to why students keep using e-learning following the epidemic. Furthermore, the findings of the current study provide an innovative perspective for Bangladeshi university administration and policymakers to assess and apply to ensure the successful application of e-learning technologies.
Is the frontal sinus immune to carcinoma? A retrospective study and review of the literature
Authors: Rifai Mohamed , Zaki Maha , Abdelmalek M. E. 
Published: August 2023

Abstract
Background
Frontal sinus carcinoma is commonly seen as an extension of the ethmoid sinus, overlying skin, or lacrimal gland. The existence of this disease has been unclear. We aimed to describe the occurrence of primary frontal sinus carcinoma.

Methods
We conducted a systematic literature review and a retrospective review of the medical records at our institution in the past 10 years.

Results
Sixty-four articles were included in the literature review. Most frontal sinus carcinomas involved surrounding structures as the sphenoid or ethmoid sinus, and a primary origin in the frontal sinus could not be confirmed. No cases of primary frontal sinus carcinoma were identified at our hospital.

Conclusion
Isolated primary frontal sinus carcinoma, if exists, is very rare. There is uncertainty regarding the primary origin of frontal sinus carcinoma in most studies. The frontal sinus seems to be immune from primary carcinoma. Further studies are needed to explain such immunity.
Consensus evidence-based recommendations for transition of care for adolescents with juvenile idiopathic arthritis: meeting patients’, parents’, and rheumatologists’ perspectives
Authors: Miedany Yasser El , Abu-Zaid Mohammed Hassan , Eissa Mervat , Hassan Waleed A. , Mortada Mohamed , Tabra Samar abd Alhamed , Mohamed Sally S. , Maher Sheren Esam , Gaafary Maha El , Medhat Basma M. , Mosa Doaa Mosad , Fouad Nermeen Ahmed , Amer Youmna Ahmed , Nasef Samah Ismail , Shalaby Radwa H. , Adel Yasmin , Elkhalek Reham Abd , Mahgoub Marwa Yahia , Lotfy Hala M. 
Published: August 2023

Abstract
Background
Transition of care means the process of educating and empowering adolescents and young adults to take an active role in their own healthcare, develop decision-making skills, and eventually transition from paediatric to adult healthcare providers. Most people do not switch doctors until they are young adults, but it can be beneficial to start preparing children earlier. We aimed to develop a specific toolkit tailored to paediatric and adult rheumatologists to assist them in transitioning of care of young people with juvenile onset rheumatic musculoskeletal diseases from the paediatric to adult rheumatology care.

Results
The expert panel was confined to an online survey (n = 18), all the experts completed the two rounds. At the conclusion of round 2, a total of 10 points were gathered. The range of respondents (ranks 7–9) who agreed with the recommendations was 88.9 to 100%. All 10 clinical standards identified by the scientific committee were written in the same way. Based on the answers to the structured key questions and the literature review, a structured template was developed presenting transition of care integrated pathway.

Conclusion
The developed rheumatology-specific guideline offers adolescents and young adults a focussed, multidisciplinary transition of care approach with equity of access, quality of care and flexibility and set up standards for transitional care for young adults with juvenile rheumatological diseases.
A Year at the Forefront of Gliding Locomotion
Authors: Khandelwal Pranav C. , Zakaria Mohamed A. , Socha John J. 
Published: August 2023

ABSTRACT
This review highlights the largely understudied behavior of gliding locomotion, which is exhibited by a diverse range of animals spanning vertebrates and invertebrates, in air and in water. The insights in the literature gained from January 2022 to December 2022 continue to challenge the previously held notion of gliding as a relatively simple form of locomotion. Using advances in field/lab data collection and computation, the highlighted studies cover gliding in animals including seabirds, flying lizards, flying snakes, geckos, dragonflies, damselflies, and dolphins. Altogether, these studies present gliding as a sophisticated behavior resulting from the interdependent aspects of morphology, sensing, environment, and likely selective pressures. This review uses these insights as inspiration to encourage researchers to revisit gliding locomotion, both in the animal's natural habitat and in the laboratory, and to investigate questions spanning gliding biomechanics, ecology, sensing, and the evolution of animal flight.
Glucose oxidation drives trunk neural crest cell development and fate
Authors: Nekooie Marnany Nioosha , Fodil Redouane , Féréol Sophie , Dady Alwyn , Depp Marine , Relaix Frederic , Motterlini Roberto , Foresti Roberta , Duband Jean-Loup , Dufour Sylvie 
Published: August 2023

ABSTRACT
Bioenergetic metabolism is a key regulator of cellular function and signaling, but how it can instruct the behavior of cells and their fate during embryonic development remains largely unknown. Here, we investigated the role of glucose metabolism in the development of avian trunk neural crest cells (NCCs), a migratory stem cell population of the vertebrate embryo. We uncovered that trunk NCCs display glucose oxidation as a prominent metabolic phenotype, in contrast to what is seen for cranial NCCs, which instead rely on aerobic glycolysis. In addition, only one pathway downstream of glucose uptake is not sufficient for trunk NCC development. Indeed, glycolysis, mitochondrial respiration and the pentose phosphate pathway are all mobilized and integrated for the coordinated execution of diverse cellular programs, epithelial-to-mesenchymal transition, adhesion, locomotion, proliferation and differentiation, through regulation of specific gene expression. In the absence of glucose, the OXPHOS pathway fueled by pyruvate failed to promote trunk NCC adaptation to environmental stiffness, stemness maintenance and fate-decision making. These findings highlight the need for trunk NCCs to make the most of the glucose pathway potential to meet the high metabolic demands appropriate for their development.
Armored heart as an image of constrictive pericarditis - a review of the literature
Authors: Wokurka Wojciech , Węgrzyniak Agata , Drobek Dominik , Winiarz Aleksandra , Szlendak Paula , Toś Katarzyna , Wojtala Kacper , Turek Michał , Wąsala Katarzyna , Grosman Sylwia 
Published: August 2023

Introduction: Pericarditis is diagnosed among 5% patients hospitalized due to chest pain. It is included in pericardial syndromes together with constrictive pericarditis, pericardial effusion and cardiac tamponade. There are many documented etiological factors leading to pericarditis, most commonly divided into infectious and non-infectious ones. The disease typically presents with chest pain, ECG changes, pericardial rub and pericardial effusion. The diagnosis is made with the results of parameters found in patients’ blood and imaging tests. Treatment is usually based on pharmacological therapy, although in some cases the pericardial surgery is necessary. One of the characteristic changes in imaging diagnostics in patients with pericarditis is thickening of pericardial layers, the so-called armored heart.
Aim of the study: The aim of the study was to find clear diagnostic criteria for armored heart as a unique type of constrictive pericarditis.
Materials and methods: Articles available in the databases of medical publications: PubMed, Google Scholar, SCOPUS were analysed using the search phrase: armored heart* AND (pericarditis OR acute pericarditis).
Results: The search phrase was included in 18 records. After the initial verification, repetitive, unavailable and foreign papers were rejected. Finally, 3 manuscripts were included in further analyses. No clear criteria were found to classify constrictive pericarditis as an armored heart.
Conclusions: Armored heart is a 'subtype' of constrictive pericarditis. It seems that this term is used subjectively, based on imaging studies.
Hearing Loss in Adults - Silent Epidemic
Authors: Magda Inga , Gaik Magdalena , Uram Ewa , Bogacz Rafał , Osuch Magdalena , Woźniak Justyna , Womperski Karol 
Published: August 2023

Introduction: Hearing loss affects 15% of Poles, i.e. more than 5.7 million people. Despite this, it is still underdiagnosed and insufficiently often treated. As its incidence increases significantly with age, this issue will only affect more people with a rapidly ageing population. Hearing loss has a number of different negative consequences, significantly reducing patients' quality of life, but it is also a problem for society as a whole.Aim of the study: Review of current knowledge on hearing loss, detailing pathophysiology, prevention, screening, diagnosis and treatment.Methods and materials: A review of chosen literature in the PubMed database, Scopus, and Google Scholar using the keywords of “hearing loss”, „ conductive hearing loss”, “sensorineural hearing loss”, “hearing loss in adults”, “diagnosing hearing loss” and „hearing loss treatment”.
Results: Hearing loss is categorized as conductive, sensorineural or mixed, with the most common being presbyacusis. Although it is a multi-factorial condition, reducing exposure to excessive noise is most important. There is no consensus on screening in adults. Various diagnostic methods exist with tonal audiometry being the most important. Conductive hearing loss is potentially amendable surgically, while in case of sensorineural hearing loss, hearing aids are the most common treatment method. Satisfactory results in the treatment of severe hearing loss and deafness can be achieved with cochlear implants. Recent research offers hope for the future of hearing loss treatment.
Conclusions: Timely diagnosis, which can be performed with relatively simple tools, is of the utmost importance. There are a number of treatment methods, which must be individually selected with the patient's participation, that yield good results.
Branched-Chain Amino Acids (BCAAs) - oral supplementation and its effects in resistance training and treatment
Authors: Bieńkowski Borys , Feja Krzysztof , Łuczak Ewa , Jachowicz Krzysztof , Petryla Piotr , Suwała Zuzanna , Marchewka Urszula , Ostafin Kamil , Rektor Natalia , Edyko Krzysztof 
Published: August 2023

Introduction: Branched - chain amino acids (BCAAs) are essential components of proteins that play a crucial role in regulating numerous physiological processes in the human body. This article provides a comprehensive analysis of scientific research on BCAAs, including their involvement in metabolism, protein biosynthesis, and the regulation of anabolic processes. We reviewed the supplementation of BCAAs and its impact on sports performance, body composition, and the therapeutic applications of BCAAs
Materials and methods: This study is based on medical articles collected from the PubMed database spanning the years 2011-2023. The research was conducted through the analysis of keywords such as "BCAA supplementation", "BCAA metabolism", and "BCAA treatment".
Results: The physiology of BCAAs is well understood. The use of oral supplements containing BCAAs does not have a positive impact on muscle hypertrophy, muscle strength, and post-workout muscle soreness in resistance training. However, branched chain amino acids may serve as a safe and effective therapeutic approach in the treatment of liver cirrhosis.
High-sensitivity fiber optic Fabry–Perot ultrasonic sensor based on a grooved silicon diaphragm for partial discharge detection
Authors: Zhang Lina , Huang Yi , Niu Xiling , Wang Liangjie , Hu Chengyong , Deng Chuanlu , Wu Peng , Lu Yuncai , Li Qun , Dong Yanhua , Zhang Qi , Zhang Xiaobei , Wang Tingyun 
Published: August 2023

An extrinsic fiber optic Fabry–Perot interferometric (EFPI) ultrasonic sensor based on a grooved silicon diaphragm for partial discharge (PD) detection has been proposed. The size of the groove is determined by finite element simulation, which allows the resonant frequency of the sensor to meet the requirements of PD ultrasonic detection and improves the sensitivity of the sensor by 5.07 times compared with that based on a traditional circular diaphragm. The microelectro–mechanical system process is used to fabricate the diaphragm on a silicon-on-insulator wafer, and the prepared diaphragm has a grooved section with a diameter of 829.34 µm and a thickness of only 2.09 µm. At its resonant frequency of 61.5 kHz, the acoustic pressure sensitivity of the sensor is 172.42 mV/Pa. The ultrasonic signal detection capability of the sensor is verified in the PD experiment. Furthermore, the characteristics of the corona discharge are successfully manifested based on the ultrasonic waves detected by the EFPI sensor. It is demonstrated that the proposed sensor is suitable for PD detection due to its high sensitivity, simple production process, and good resistance to environmental interference.
Multi-longitudinal mode laser beat-frequency optical fiber vibration sensing system based on an FM radio module
Authors: Wang Xu , Wang Shanjin , Zhou Ziqiang , Wang Fang 
Published: August 2023

A multi-longitudinal mode (MLM) laser beat-frequency optical fiber vibration sensor using a frequency modulation (FM) radio integrated circuit module as the FM demodulation scheme is presented and demonstrated. To the best of our knowledge, this is the first case where a fiber-optic sensing system is combined with an FM radio module, and dynamic sensing is well achieved. As the carrier of the vibration source, the beat-frequency signal (BFS) generated by the MLM laser is transmitted to the FM radio module for FM and demodulation. The experimental results show that the system can successfully detect the vibration signal in the frequency range of 20 Hz to 18 kHz and accurately demodulate the waveform and amplitude of the vibration signal source. The minimum shape variable detected by the system is 20.67 nm, based on the performance of the commercial FM radio module itself, which can effectively solve the problem of detecting tiny vibration. The idea of the optical fiber vibration sensing system is extremely innovative, with high sensitivity, high signal-to-noise ratio (SNR), good stability, and strong resistance to electromagnetic interference.
Safety and immunogenicity of a new formulation of a pentavalent DTwP-HepB-Hib vaccine in healthy Indian infants–A randomized study
Authors: Aloysia D’Cor Naveena , Siddaiah Prashanth , Mohapatra Satyajit , Dhaded Sangappa Malappa , I. V. Padmavathi , Kar Sonali , V. N. Tripathi , Muley Prasad , Chhatwal Jugesh , Patnaik Badri Narayan , Vidor Emmanuel , Moureau Annick , Patel Dhaval M. , Midde Venkata Jayanth , Jagga Sathish Reddy , Peesapati Satyanarayana , Noriega Fernando 
Published: August 2023

Background
Pentavalent vaccines (DTP-HepB-Hib) have been introduced in many countries in their routine public immunization programmes to protect against diphtheria (D), tetanus (T), pertussis (P), hepatitis B (Hep B) and Hemophilus influenzae type b (Hib) diseases. This study compared the safety and immunogenicity of a new formulation of a whole-cell Bordetella pertussis (wP) based pentavalent vaccine (DTwP-HepB-Hib). The new formulation was developed using well-characterized hepatitis B and pertussis whole cell vaccine components.

Methods
This was a phase III, observer-blind, randomized, non-inferiority, multi-center study conducted in India among 460 infants who were followed up for safety and immunogenicity for 28 days after administration of three doses of either investigational or licensed comparator formulations at 6–8, 10–12 and 14–16 weeks of age.

Results
The investigational formulation of DTwP-HepB-Hib vaccine was non-inferior to the licensed formulation in terms of hepatitis B seroprotection rate (% of subjects with HepB antibodies ≥10mIU/mL were 99.1% versus 99.0%, respectively, corresponding to a difference of 0.1% (95% CI, -2.47 to 2.68)) and pertussis immune responses (adjusted geometric mean concentrations of antibodies for anti-PT were 76.7 EU/mL versus 63.3 EU/mL, with a ratio of aGMTs of 1.21 (95% CI, 0.89–1.64), and for anti-FIM were 1079 EU/mL versus 1129 EU/mL, with a ratio of aGMTs of 0.95 (95% CI, 0.73–1.24), respectively). The immune responses to other valences (D, T, and Hib) in the two formulations were also similar. The safety profile of both formulations was found to be similar and were well tolerated.

Conclusions
The investigational DTwP-HepB-Hib vaccine formulation was immunogenic and well-tolerated when administered as three dose primary series in infants.

Clinical trial registration
Clinical Trials Registry India number: CTRI/2018/12/016692.
The Family Involvement in Care Questionnaire—An instrument measuring family involvement in inpatient care
Authors: Drakenberg Anna , Prignitz Sluys Kerstin , Ericsson Elisabeth , Sundqvist Ann-Sofie 
Published: August 2023

BackgroundFamily involvement in care can be seen as a prerequisite for high-quality family-centered care. It has been identified to improve both patient safety and the quality of care by reducing patient complications and hospital length of stay.ObjectiveTo develop and evaluate the content validity of a questionnaire measuring family involvement in inpatient care.MethodsThe study followed a systematic approach in building a rigorous questionnaire: identification of domain, item generation, and assessment of content validity. The content validity index was calculated based on ratings of item relevance by an expert group consisting of seven senior nurses. Subsequently, 19 online cognitive interviews using the Think-aloud method were conducted with family members of former patients who had undergone open-heart surgery.ResultsFive aspects of family involvement were identified, and the initial pool of items were selected from two preexisting questionnaires. The experts’ ratings resulted in item content validity of 0.71–1.00, and the scale content validity/averaging was 0.90, leading to rewording, exclusion, and addition of items. The pretesting of items through two rounds of cognitive interviews with family members resulted in the identification of three main problem areas: defining family involvement, misinterpretation of different terms, and underuse of the not relevant response option. The problems were adjusted in the final version of the questionnaire, which consists of 16 items with a four-point Likert scale and two open-ended items.ConclusionsThe Family Involvement in Care Questionnaire has demonstrated potential in evaluating family involvement in inpatient care. Further psychometric properties regarding reliability and validity need to be established.