bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gilteritinib in Combination With Induction and Consolidation Chemotherapy and as Maintenance Therapy: A Phase IB Study in Patients With Newly Diagnosed AML
Authors: Pratz Keith W. , Cherry Mohamad , Altman Jessica K. , Cooper Brenda W. , Podoltsev Nikolai A. , Cruz Jose Carlos , Lin Tara L. , Schiller Gary J. , Jurcic Joseph G. , Asch Adam , Wu Ruishan , Hill Jason E. , Gill Stanley C. , James Angela J. , Rich Elizabeth Shima , Hasabou Nahla , Perl Alexander E. , Levis Mark J. 
Published: June 2023

PURPOSE Gilteritinib is a type 1 FLT3 inhibitor active as monotherapy for relapsed or refractory FLT3-mutated AML. We investigated the safety, tolerability, and efficacy of gilteritinib incorporated into intensive induction and consolidation chemotherapy, and as maintenance therapy for adult patients with newly diagnosed, non–favorable-risk AML. METHODS In this phase IB study (2215-CL-0103; ClinicalTrials.gov identifier: NCT02236013 ), 103 participants were screened and 80 were allocated to treatment. The study was divided into four parts: dose escalation, dose expansion, investigation of alternate anthracycline and gilteritinib schedule, and continuous gilteritinib during consolidation. RESULTS After dose escalation, 120 mg gilteritinib once daily was chosen for further study. There were 58 participants evaluable for response at this dose, 36 of whom harbored FLT3 mutations. For participants with FLT3-mutated AML, the composite complete response (CRc) rate was 89% (83% were conventional complete responses), all achieved after a single induction cycle. The median overall survival time was 46.1 months. Gilteritinib was well-tolerated in this context although the median time to count recovery during induction was approximately 40 days. Longer time-to-count recovery was associated with higher trough levels of gilteritinib, which, in turn, were associated with azole use. The recommended regimen is gilteritinib at a dose of 120 mg once daily from days 4 to 17 or 8 to 21 of a 7 + 3 induction with either idarubicin or daunorubicin and from day 1 continuously with high-dose cytarabine consolidation. Maintenance therapy with gilteritinib was well-tolerated. CONCLUSION These results demonstrated the safety and tolerability of gilteritinib incorporated into an induction and consolidation chemotherapy regimen, and as single-agent maintenance therapy for patients with newly diagnosed FLT3-mutant AML. The data herein provide an important framework for the design of randomized trials comparing gilteritinib with other FLT3 inhibitors.
FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study
Authors: Tournigand Christophe , André Thierry , Achille Emmanuel , Lledo Gérard , Flesh Michel , Mery-Mignard Dominique , Quinaux Emmanuel , Couteau Corinne , Buyse Marc , Ganem Gérard , Landi Bruno , Colin Philippe , Louvet Christophe , de Gramont Aimery 
Published: June 2023

PURPOSE In metastatic colorectal cancer, phase III studies have demonstrated the superiority of fluorouracil (FU) with leucovorin (LV) in combination with irinotecan or oxaliplatin over FU + LV alone. This phase III study investigated two sequences: folinic acid, FU, and irinotecan (FOLFIRI) followed by folinic acid, FU, and oxaliplatin (FOLFOX6; arm A), and FOLFOX6 followed by FOLFIRI (arm B). PATIENTS AND METHODS Previously untreated patients with assessable disease were randomly assigned to receive a 2-hour infusion of l-LV 200 mg/m2 or dl-LV 400 mg/m2 followed by a FU bolus 400 mg/m2 and 46-hour infusion 2,400 to 3,000 mg/m2 every 46 hours every 2 weeks, either with irinotecan 180 mg/m2 or with oxaliplatin 100 mg/m2 as a 2-hour infusion on day 1. At progression, irinotecan was replaced by oxaliplatin (arm A), or oxaliplatin by irinotecan (arm B). RESULTS Median survival was 21.5 months in 109 patients allocated to FOLFIRI then FOLFOX6 versus 20.6 months in 111 patients allocated to FOLFOX6 then FOLFIRI ( P = .99). Median second progression-free survival (PFS) was 14.2 months in arm A versus 10.9 in arm B ( P = .64). In first-line therapy, FOLFIRI achieved 56% response rate (RR) and 8.5 months median PFS, versus FOLFOX6 which achieved 54% RR and 8.0 months median PFS ( P = .26). Second-line FOLFIRI achieved 4% RR and 2.5 months median PFS, versus FOLFOX6 which achieved 15% RR and 4.2 months PFS. In first-line therapy, National Cancer Institute Common Toxicity Criteria grade 3/4 mucositis, nausea/vomiting, and grade 2 alopecia were more frequent with FOLFIRI, and grade 3/4 neutropenia and neurosensory toxicity were more frequent with FOLFOX6. CONCLUSION Both sequences achieved a prolonged survival and similar efficacy. The toxicity profiles were different.
Ειδικά θέματα Φωτογραμμετρίας για animation.
Authors: Αναστασία  , ΣΙΑΚΑΣ Σπύρος 
Published: June 2023

Η εργασία αυτή αφορά στην αξιοποίηση της Φωτογραμμετρίας στο χώρο του animation. Τόσο στην περίπτωση των ταινιών όσο και στην περίπτωση των gamification εφαρμογών. Μελετώνται οι εξελίξεις στο χώρο της Φωτογραμμετρίας από θέμα λογισμικών και μέσων λήψης αλλά και οι ανάγκες σε τρισδιάστατα μοντέλα σε μια παραγωγή animation για ταινία ή gamification εφαρμογή. Γίνεται μια κατηγοριοποίηση όσον αφορά στο θέμα της λήψης μέσα σε στούντιο ειδικά διαμορφωμένο, σε Μουσείο ή σε εξωτερικό χώρο. Επίσης επιχειρείται κατηγοριοποίηση και ως προς το μέγεθος των προς αποτύπωση μοντέλων. Διερευνώνται και καταγράφονται σημαντικοί παράγοντες επιτυχίας της διαδικασίας αλλά και περιπτώσεις δυσκολίας με αποτυχημένο αποτέλεσμα. Σημαντικές εργασίες που αξιοποιούνται για παρατήρηση είναι η διαδραστική έκθεση « Μορφές Ελευθερίας», η 3D animation ταινία «Ανοιχτά φτερά» αλλά και Φωτογραμμετρία που έγινε σε πολλά Λαογραφικά Μουσεία. Τα συμπεράσματα σκοπό έχουν να συντελέσουν στην επιτυχημένη και συστηματική αξιοποίηση της Φωτογραμμετρίας σε παραγωγή τρισδιάστατων μοντέλων για αξιοποίηση στο χώρο του animation σε όλες τις εκδοχές του.
Μια συγκριτική μελέτη σπουδών κινηματογραφικής εκπαίδευσης στην Ελλάδα
Authors: Τριβέλλα Λαμπρινή , Ζερεφός Στυλιανός , ΣΙΑΚΑΣ Σπυρίδων , Βλαβιανού Αντιγόνη , Σακαρίδης Ιωάννης 
Published: June 2023

Η παρούσα εργασία περιγράφει το πλαίσιο ανάπτυξης ενός ανοικτού προγράμματος κινηματογραφικών σπουδών σε περιβάλλον εξ αποστάσεως εκπαίδευσης σε ανώτατα εκπαιδευτικά ιδρύματα, με βάση συγκεκριμένες προδιαγραφές και αρχές μάθησης, ενώ επιχειρεί τη συγκριτική ανάλυσή του με υφιστάμενα αντίστοιχα συμβατικά προγράμματα σπουδών.
Αρχικά, προσδιορίζονται οι βασικές αρχές ανάπτυξης προγραμμάτων σπουδών με βάση τα διεθνή πρότυπα, όπως ορίζονται από την UNESCO, EUA, σε συνδυασμό με αρχές ενεργητικής και φοιτητοκεντρικής μάθησης στην εξ Αποστάσεως Εκπαίδευση (εξΑΕ).
Με βάση αυτό το θεωρητικό πλαίσιο, μελετάται η περίπτωση του εν λειτουργία προπτυχιακού προγράμματος σπουδών «Σπουδές Κινηματογραφικής Γραφής, Πρακτικής και Έρευνας (ΣΚΙ)» του Ελληνικού Ανοικτού Πανεπιστημίου (ΕΑΠ), συγκριτικά με τα αντίστοιχα προγράμματα προπτυχιακών σπουδών στην Ελλάδα.
How to link organizational resilience to transformational entrepreneurship behavior as theoretical framework gap – A systematic literature review
Authors: Gunawan Michael , Soetjipto Budi , Sudhartio Lily 
Published: June 2023

Background: Numerous enterprises face great challenges during uncertain economic conditions. This is particularly true for micro, small, and medium-scale companies, which are slumped against disruption from the COVID-19 pandemic—owing to lockdowns, decreased demand, and a disrupted supply chain. This has impacted the economy worldwide but also the social community and the environment that forms its ecosystem. Organizational resilience allows for socio-economic growth and enterprises to build environmental sustainability and balanced community development. Therefore, the behavior of companies must be transformed in building entrepreneurship to encourage socio-economic growth. Methods: We conducted an advanced search on Business Source Premier, ABI/INFORM (ProQuest), Emerald Insight, and Web of Science database between March and June 2022. We screened the bibliographies of the articles from the database search using a set of inclusion criteria such as studies with quantitative design with unit analysis population sample based microfinance institutions and cooperative-based microfinance institutions, MSEs, and MSMEs as well as other industries such as travel agents, property, restaurants, food and beverages, manufacturing and plantations; exploration of transformational entrepreneurship behavior and organizational resilience determinant factors and conceptual manuscripts written in English; and published between 2005 till 2019 for transformational entrepreneurship and 1997 till 2000 for organizational resilience. Results: This study reviewed 22 articles focusing on the role and influence of organizational resilience on transformational entrepreneurship behavior from a lens that posits the importance of organizational resilience in the face of uncertain economic turbulence. The orientation of entrepreneurship behavior has been neglected in research so far. This systematic literature review study reveals important research gaps, such as the influence of organizational resilience in promoting the development of transformational entrepreneurship behavior and the determinants that build organizational resilience. Conclusions: Research related to a company’s transformational entrepreneurship behavior offers a broad area of ​​scientific research; hence, encouraging further investigation is necessary.
Secondary polycythemia and venous thromboembolism: a systematic review
Authors: Panjwani Amelia , Burle Venkata Sathya , Raj Rhea , Thomas Sneha , Gorantla Vasavi 
Published: June 2023

Background Secondary polycythemia is an acquired condition characterized by an elevation in red blood cell (RBC) mass either in response to tissue hypoxia or inappropriate erythropoietin (EPO) secretion. It is proposed that the elevation of RBC mass in secondary polycythemia can lead to hyperviscosity and VTE. This systematic review aims to assess the relationship between secondary polycythemia and venous thromboembolism and discuss diagnostic strategies and management of secondary polycythemia and VTE. Methods This systematic review was conducted on September 2, 2022, and followed PRISMA guidelines to select and analyze relevant articles using the following databases: PubMed, ScienceDirect, and CINAHL. The queries used were “secondary polycythemia AND venous thromboembolism,” “secondary polycythemia AND deep vein thrombosis,” “secondary polycythemia AND pulmonary embolism,” “chronic obstructive pulmonary disease AND venous thromboembolism,” “chronic obstructive pulmonary disease AND deep vein thrombosis,” “chronic obstructive pulmonary disease AND pulmonary embolism,” “high altitude AND venous thromboembolism,” “high altitude AND deep vein thrombosis,” “high altitude AND pulmonary embolism,” “smoking AND venous thromboembolism,” “smoking AND deep vein thrombosis”, “smoking AND pulmonary embolism”, “hypoventilation AND venous thromboembolism”, “hypoventilation AND deep vein thrombosis”, “hypoventilation AND pulmonary embolism”, “testosterone AND venous thromboembolism”, “testosterone AND deep vein thrombosis”, and “testosterone AND pulmonary embolism.” The search duration was set from 2012–2022. Relevant publications were selected based on the inclusion and exclusion criteria. Results The initial search generated 5,946 articles. After narrowing the search based on inclusion and exclusion criteria, 30 articles were selected for this systematic review. Conclusion We found evidence to support the relationship between secondary polycythemia and VTE. Therapies targeting the factors that lead to secondary polycythemia can correct it and prevent VTE progression. If VTE occurs as a result of secondary polycythemia, anticoagulation therapy is recommended or inferior vena cava filters if contraindicated.
Krzemień jurajski podkrakowski w neolicie ziemi chełmińskiej
Authors: Małecka-Kukawka Jolanta 
Published: June 2023

Artykuł prezentuje dane dotyczące materiałów krzemiennych z surowca jurajskiego podkrakowskiego w inwentarzach kultury ceramiki wstęgowej rytej, kultury późnej ceramiki wstęgowej i kultury pucharów lejkowatych. Dotychczasowe studia nad krzemieniarstwem neolitycznym wykazały, że obszar ten był włączony w dalekosiężną wymianę surowców ze skał krzemionkowych pochodzących z południa – z krzemienionośnego obrzeżenia Gór Świętokrzyskich (krzemień jurajski podkrakowski, krzemień świeciechowski, krzemienie czekoladowe) i południowego wschodu – Wyżyny Ukraińskiej (surowce „wołyńskie”).
A review of the possibilities of gene doping in sports focused on the advantages and disadvantages
Authors: Bara Sebastian , Barczuk Patryk , Gałajda Elżbieta , Antonik Jacek , Barczak Iga , Barć Jan , Kochan Robert , Bączek Kacper , Dzięgielewski Jędrzej , Bondos Borys 
Published: June 2023

Introduction and purpose: Gene therapy can be defined as a modification of gene expression in a patient's body. There are two main strategies: the abuse of "classical" gene therapy and strategies of RNA interference with gene transfer. The aim of the study is to analyze scientific literature on gene doping, with a focus on the advantages and disadvantages of using genes related to sports.
Materials and methods: The literature available on PubMed was reviewed using the words “gene therapy”, “sport”.
Description of the state of knowledge:
The potential modification of genes such as EPO, IGF1/GH, HIF-1, PPAR have been identified as having beneficial effects for athletes. Modifying the EPO gene could lead to an increase in red blood cells and oxygen in the blood, which could increase muscle endurance. Modification of the IGF1/GH gene can lead to muscle hypertrophy, block muscle atrophy. The HIF-1 gene codes proteins involved in the hypoxia process and can increase endurance by facilitating the adaptation of cells to low oxygen conditions. Modifying the PPAR gene can impact carbohydrate and lipid metabolism, regulating body mass. Gene therapy could provide a potential cure for diseases such as acute anemia and muscular dystrophy. However, it is important to consider the ethical and health implications of gene doping.
Summary: "Gene doping" is a practice that can lead to improved athletic performance but also to serious health problems. The introduction of regulations and doping tests detecting changes in the genome would exclude this practice among athletes who take risky and morally incorrect actions. Increasing the expression of genes such as EPO, IGF-1, HIF-1, PCK1 results in increased muscle endurance and performance. Further research is needed to understand the exact mechanisms and effects of gene therapy. Genetic modification has the potential to bring benefits such as treating diseases such as acute anemia resulting from kidney failure.
Neutralność Szwajcarii
Authors: Popławski Dariusz 
Published: June 2023

SWISS NEUTRALITY: CHALLENGES OF THE 21ST CENTURY
The main research objective of the article is to show the evolution of Switzerland’s neutrality after the Cold War. Based on the analysis of internal and external conditions, the thesis is formulated that in the conceptual sphere, Switzerland refers to the traditional principles of perpetual neutrality, both in official positions as well as political rhetoric. This aspect clearly distinguishes it from the neutral and non-aligned European Union states. At the same time, in the realm of implementation, it is actually shifting to positions of non-alignment/post-neutrality. The main components of the redefinition of neutrality materialised in the form of a rejection of the principles of the so-called economic neutrality as well as a change of attitude towards armed conflicts. Their implementation opened up opportunities for participation in the process of European integration and a broader commitment to international solidarity as well as management crises. It was in line with the expectations of the international community. The lack of consequences was critically assessed as well as the main barriers to the implementation of the principles of the new concept of neutrality in the 1990s. The beginning of the 21st century brings a clear stabilisation of Helvetic neutrality, including changes in the field of cooperative security policy. Joining the European Union’s sanctions against Russia confirms the continuity of the assumptions of the post-Cold War concept of neutrality.
Using Software Containers for Privileged Access Management in Cloud Environments: A Novel Approach to Handle Access Management for Cloud-based Networks
Authors: Steinhoff Marleen 
Published: June 2023

This paper presents a novel approach for privileged access and session management using containers. Current solutions are built using proxies, proxy suites or jump servers, but they do not cater for third party remote access security requirements, have additional vulnerabilities and have scalabilty limitations.
The novelty of the solution proposed in this paper is a global orchestrator that instantiates a purpose-built container adapted to the virtual network functions’ system. Every container has a logging function, a pre-defined time-to-live and one-time-credentials. This approach is secure because the containers isolate different connections, privileges are restricted, permissions are always time-limited and the provider has full control over the sessions. The solution brings several other security enhancements, discussed in this paper.
Multiple bound states in the continuum based on the dielectric metasurface
Authors: Xie Suxia , Yang Jingcheng , Shen Weiwei , Bai Chongjun , Sun Siyi , Guan Xin 
Published: June 2023

Optical metasurfaces with high quality factors (Q-factors) of bound states in the continuum (BICs) can substantially boost light–matter interaction for various applications in ultrathin and active metadevices. In this paper, we propose a metasurface supporting both at Γ BICs and off Γ BICs, and they can be modulated regularly. The sensitivities of the monolayer and bi-layer structures can reach 157.918 nm/RIU and 165.76 nm/RIU, respectively, at incident angles of 0.01 deg. For the bi-layer metasurface, four BICs at Γ point are achieved, and they are influenced by the structural parameters dramatically. Additionally, the four at Γ BICs coincide into two and then behave similarly to the monolayer case with the distance being large enough, which is associated with the BICs becoming uncoupled when the layers get far from each other. Furthermore, similar behaviors (four at Γ BICs coincide into two) are observed by varying the nanopore size in one layer of the bi-layer metasurface. For an oblique incidence, two off Γ BICs show up, and their center wavelengths have a dependent relationship with the size of the nanopores and the distance between layers. The results for monolayer and bi-layer metasurfaces are useful for potential applications based on BICs, such as sensors and filters.
Impact of a bi-annual community-directed treatment with ivermectin programme on the incidence of epilepsy in an onchocerciasis-endemic area of Mahenge, Tanzania: A population-based prospective study
Authors: Bhwana Dan , Amaral Luís-Jorge , Mhina Athanas , Hayuma Paul Martine , Francis Filbert , Siewe Fodjo Joseph N. , Mmbando Bruno P. , Colebunders Robert 
Published: June 2023

BackgroundCommunity-directed treatment with ivermectin (CDTi) is used to eliminate onchocerciasis. However, despite 25 years of annual CDTi in Mahenge, Tanzania, the prevalence of onchocerciasis and onchocerciasis-associated epilepsy remained high in certain rural villages. Therefore, in 2019, bi-annual CDTi was introduced in the area. This study assessed the impact of the programme on the incidence of epilepsy in four villages.MethodologyDoor-to-door epilepsy surveys were conducted prior to (2017/18) and after (2021) implementing a bi-annual CDTi program. All household members were screened for epilepsy symptoms using a validated questionnaire, and suspected cases were examined by a medical doctor to confirm/reject the diagnosis of epilepsy. The prevalence and annual incidence of epilepsy, including nodding syndrome, were calculated with 95% Wilson confidence intervals with continuity correction. The latter was also done for CDTi coverage in 2016 and 2021.ResultsPrecisely 5,444 and 6,598 persons were screened for epilepsy before and after implementing the intervention. The CDTi coverage of the overall population was 82.3% (95%CI: 81.3–83.2%) in 2021 and sustained in both distribution rounds (81.5% and 76.8%). The coverage was particularly high in children and teenagers aged 6 to 18 years (93.2%, 95%CI: 92.1–94.2%). The epilepsy prevalence remained similar: 3.3% (95%CI: 2.9–3.9%) in 2017/18 versus 3.1% (95%CI: 2.7–3.5%) in 2021. However, the incidence of epilepsy declined from 177.6 (95%CI: 121.2–258.5) in 2015–2017 and 2016–2018 to 45.5 (95%CI: 22.2–89.7) in 2019–2021 per 100,000 persons-years. The incidence of probable nodding syndrome varied from 18.4 (95%CI: 4.7–58.5) to 5.1 (95%CI: 0.3–32.8). None of the nine incidence cases of epilepsy for which information on ivermectin intake was available took ivermectin in the year they developed their first seizures.ConclusionA bi-annual CDTi programme should be implemented in areas with high prevalence of onchocerciasis and epilepsy. High CDTi coverage among children is particularly important to prevent onchocerciasis-associated epilepsy.
The impact of university STEM assets: A systematic review of the empirical evidence
Authors: Billing Chloe , Bramley George , Ioramashvili Carolin , Lynam Robert , Cepeda Zorrilla Magda , Collinson Simon , Humphreys Kelvin , Kollydas Konstantinos , Pan Fengjie , Pugh Alice , Sevinc Deniz , Yuan Pei-Yu 
Published: June 2023

Background
Innovation ecosystems are an important driver of regional economic growth and development. STEM assets connected to universities may play an important role in such ecosystems.

Objective
To systematically review the literature relating to the effect of university STEM assets on regional economies and innovation ecosystems, providing a better understanding of how the impact is generated and constrained, as well as identifying any gaps in knowledge.

Methods
Keyword and text word searches using the Web of Science Core Collection (Clarivate), Econlit (EBSCO) and ERIC (EBSCO) were performed in July 2021 and February 2023. Papers were double screened on abstract and title, and were included if there was consensus that they fulfilled the inclusion criteria of: (i) relating to an OECD country; (ii) having been published between 1 January 2010 and 28 February 2023; and (iii) concerning the impact of STEM assets. Data extraction was undertaken for each article by a single reviewer and checked by a second reviewer. Due to the heterogeneity of the study designs and outcome measures used, it was not possible to perform a quantitative synthesis of results. A narrative synthesis was subsequently undertaken.

Results
Of the 162 articles identified for detailed review, 34 were accepted as being sufficiently relevant to the study to be included for final analysis. Three important features identified were that the literature: i) is predominately concerned with supporting new businesses; ii) describes a high level of involvement with a university in providing that support; and iii studies economic impacts at local, regional and national levels.

Discussion
The evidence points to a gap in the literature relating to looking at the broader impact of STEM assets and any corresponding transformational, system-level effects that go beyond narrowly defined, short to medium-term outcomes. The main limitation of this review is that information on STEM assets in the non-academic literature is not captured.