bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and genotypic identification of carbapenem resistance in Bacteroides fragilis clinical strains
Authors: Kierzkowska Marta , Majewska Anna , Karłowicz Konrad , Pituch Hanna 
Published: May 2023

AbstractBacteroides fragilis is an important etiological agent of serious infections in humans. Rapid methods, readily adaptable to use in medical laboratories, are needed to detect antibiotic resistance and decrease the likelihood of therapy failure. The aim of this study was to determine the prevalence of B. fragilis cfiA-positive isolates. The second purpose was to investigate the carbapenemase activity in B. fragilis strains by Carba NP test. In the study, 5.2% of B. fragilis isolates are phenotypically resistant to meropenem. The cfiA gene was identified in 6.1% of B. fragilis isolates. The MICs of meropenem were significantly higher in cfiA-positive strains. The presence of the cfiA gene along with the IS1186 was detected in one B. fragilis strain which was resistant to meropenem (MIC 1.5 mg/L). The Carba NP test results were positive for all the cfiA-positive strains, including those susceptible to carbapenems based on their MIC values. A review of the literature revealed that the rate of B. fragilis with the cfiA gene varies from 7.6 to 38.9% worldwide. Presented results are in line with the other European studies. Phenotypic testing with the Carba NP test, it seems to be a viable alternative for the cfiA gene detection in B. fragilis isolates. The positive result obtained is of greater clinical importance than the detection of the gene cfiA.
Comparative genomic analysis of five coprinoid mushrooms species
Authors: Wang Jingjing , Zhang Ran , Ding Guoao , Wang Lingling , Wang Wei , Zhang Yan , Zhu GuiLan 
Published: May 2023

AbstractAlthough coprinoid mushrooms are widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of coprinoid mushroom species have not been extensively studied. To reveal the genomic structure and diversity in coprinoid mushroom species, the genomes of five coprinoid mushroom species were compared and analyzed. A total of 24,303 orthologous gene families, including 89,462 genes, were identified in the five species. The numbers of core, softcore, dispensable, and private genes were 5617 (25.6%), 1628 (7.4%), 2083 (9.5%), and 12,574 (57.4%), respectively. Differentiation time analysis revealed that Coprinellus micaceus and Coprinellus angulatus differentiated approximately 181.0 million years ago. Coprinopsis cinerea and Coprinopsis marcescibilis differentiated approximately 131.0 million years ago, and they were differentiated from Candolleomyces aberdarensis approximately 176.0 million years ago. Gene family contraction and expansion analyses showed that 1465 genes and 532 gene families were expanded, and 95 genes and 134 gene families were contracted. Ninety-five laccase-coding genes were detected in the five species, and the distribution of the laccase-coding genes in the five species was not uniform. These data provide a reference for a deeper understanding of the genetic structure of the genomes of coprinoid mushroom species. Furthermore, this study provides a reference for follow-up studies on the genome structure of coprinoid mushroom species and the diversity of specific functional genes.
Bioinformatics Approach to Identify the Influences of COVID-19 on Ischemic Stroke
Authors: Zhu Jiabao , Li Xiangui , Lv Fanzhen , Zhou Weimin 
Published: May 2023

AbstractAs severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is becoming more infectious and less virulent, symptoms beyond the lungs of the Coronavirus Disease 2019 (COVID-19) patients are a growing concern. Studies have found that the severity of COVID-19 patients is associated with an increased risk of ischemic stroke (IS); however, the underlying pathogenic mechanisms remain unknown. In this study, bioinformatics approaches were utilized to explore potential pathogenic mechanisms and predict potential drugs that may be useful in the treatment of COVID-19 and IS. The GSE152418 and GSE122709 datasets were downloaded from the GEO website to obtain the common differentially expressed genes (DEGs) of the two datasets for further functional enrichment, pathway analysis, and drug candidate prediction. A total of 80 common DEGs were identified in COVID-19 and IS datasets for GO and KEGG analysis. Next, the protein–protein interaction (PPI) network was constructed and hub genes were identified. Further, transcription factor–gene interactions and DEGs–miRNAs coregulatory network were investigated to explore their regulatory roles in disease. Finally, protein-drug interactions with common DEGs were analyzed to predict potential drugs. We successfully identified the top 10 hub genes that could serve as novel targeted therapies for COVID-19 and screened out some potential drugs for the treatment of COVID-19 and IS.
Designing Donation Incentive Contracts for Online Gig Workers
Authors: Reggiani Tommaso , Rilke Rainer Michael 
Published: May 2023

AbstractThis study examines the effects of donation incentives on labor supply in an online labor market through a field experiment (n = 944). We manipulate the donation purpose of the incentive to be either unifying or polarizing and the size of the donation relative to the workers’ wage. Our experimental design allows us to observe the decision to accept a job (extensive margin) and different dimensions of productivity (intensive margin). We predict and show that a unifying donation purpose attracts more gig workers and improves their productivity compared to a polarizing donation purpose. We discuss the implications of these results in order to understand the role of donation incentives and labor supply in online labor markets.
Impact of mean sea-level rise on the long-term evolution of a mega-nourishment
Authors: Ribas Francesca , Portos-Amill Laura , Falqués Albert , Arriaga Jaime , Marcos Marta , Ruessink Gerben 
Published: May 2023

AbstractMean sea-level rise (MSLR) will induce shoreline recession, increasing the stress on coastal systems of high socio-economic and environmental values. Localized mega-nourishments are meant to alleviate erosion problems by diffusing alongshore over decades and thus feeding adjacent beaches. The 21-st century morphological evolution of the Delfland coast, where the Sand Engine mega-nourishment was built in 2011, was simulated with the Q2Dmorfo model to assess the Sand Engine capacity to protect the area against the effects of MSLR. The calibrated and validated model was forced with historical wave and sea-level data and MSLR projections until 2100 corresponding to different Representative Concentration Pathways (RCP2.6, RCP4.5 and RCP8.5). Results show that the Sand Engine diffusive trend will continue in forthcoming decades, with the feeding effect to adjacent beaches being less noticeable from 2050 onward. Superimposed to this alongshore diffusion, MSLR causes the shoreline to recede because of both passive-flooding and a net offshore sediment transport produced by wave reshaping and gravity. The existing feeding asymmetry enforces more sediment transport to the NE than to the SW, causing the former to remain stable whilst the SW shoreline retreats significantly, especially from 2050 onward. Sediment from the Sand Engine does not reach the beaches located more than 6 km to the SW, with a strong shoreline and profile recession in that area, as well as dune erosion. The uncertainties in the results are dominated by those related to the free model parameters up to 2050 whilst uncertainties in MSLR projections prevail from 2050 to 2100.
Histopathological growth patterns of neuroendocrine tumor liver metastases
Authors: Meyer Y. , Bohlok A. , Olthof P. , Donckier V. , Doukas M. , Lucidi V. , Vermeulen P. , Grünhagen D. , Verhoef C. 
Published: May 2023

AbstractHistopathological growth patterns (HGPs) of liver metastases represent a potential biomarker for prognosis after resection. They have never been studied in neuroendocrine tumor liver metastases (NETLM). This study evaluated if distinct HGPs can be observed in resected NETLM and if they have prognostic value. Sixty-three patients who underwent resection of NETLM between 01–01-2001 and 31–12-2021 were retrospectively included. HGPs were scored on Haematoxylin&Eosin slides using light microscopy, distinguishing desmoplastic- (dHGP), pushing- (pHGP) and replacement HGP (rHGP). Average HGP scores were calculated per patient. Each patient was classified according to predominant HGP. Overall and Disease-Free Survival (OS and DFS) were evaluated through Kaplan–Meier analysis and Cox regression. Eighteen patients had predominant dHGP (29%), 33 had predominant pHGP (52%) and 11 had predominant rHGP (17%). One patient had mixed HGP (2%). Five-year OS was 76% (95%CI: 66–87%) for the overall cohort. Five-year OS was 92% (95%CI: 77–100%) for dHGP, was 73% (95%CI: 59–91%) for pHGP, 50% (95%CI: 25–100%) for rHGP. Five-year DFS was 39% (95%CI: 19–83%) for dHGP, 44% (95%CI: 27–71%) for rHGP and 50% (95%CI: 23–100%) for pHGP. There was no significant association between HGP and OS or DFS in multivariable analysis. Distinct HGPs could be identified in NETLM. In patients who underwent resection of NETLM, no association was found between HGPs and postoperative survival. Half of the patients with NETLM have a predominant pushing growth pattern, which is a rare growth pattern in liver metastases from breast and colorectal cancer.
Monetary policy responses to COVID-19 in emerging European economies: measuring the QE announcement effects on foreign exchange markets
Authors: Uz Akdogan Idil 
Published: May 2023

AbstractThis paper examines the effects of quantitative easing (QE) announcements by emerging market central banks in Europe during the COVID-19 pandemic, particularly on exchange rates with a higher frequency setting. Two different methodologies are used for analysing the policy announcement effects. The first methodology is the event study method that measures the sample exchange rates’ mean and cumulative mean abnormal return around the time of event. The second one is the time series approach that measures asymmetric behaviour of the exchange rate volatility to monetary policy shocks by employing exponential GARCH model. The results show that the foreign exchange markets respond to QE announcements in all selected countries. The response of exchange rates varies across countries and event windows. QE announcements cause appreciation of domestic currency in Hungary and Poland, and depreciation in Turkey. Additionally, the QE announcements increase exchange rate volatility in Hungary and Poland while they reduce volatility in Turkey. The asymmetric behaviour of domestic currencies prevails in all selected countries, but this asymmetry is sensitive to the exchange rate and the length of the window.
Asymptotic behavior of fractional-order nonlinear systems with two different derivatives
Authors: Chen Liping , Xue Min , Lopes António , Wu Ranchao , Chen YangQuan 
Published: May 2023

AbstractThis paper addresses the asymptotic behavior of systems described by nonlinear differential equations with two fractional derivatives. Using the Mittag–Leffler function, the Laplace transform, and the generalized Gronwall inequality, a sufficient asymptotic stability condition is derived for such systems. Numerical examples illustrate the theoretical results.
Validating the Communication and Symbolic Behavior Scales–Developmental Profile Infant–Toddler Checklist (CSBS–DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder
Authors: Saldaris Jacinta , Leonard Helen , Wong Kingsley , Jacoby Peter , Spence Mary , Marsh Eric D. , Benke Tim A. , Demarest Scott , Downs Jenny 
Published: May 2023

AbstractCDKL5 deficiency disorder (CDD) results in early-onset epilepsy and lifelong cognitive and motor impairments. With no validated measure for communication in CDD, this study evaluated the psychometric properties of the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist (CSBS–DP ITC). Caregivers (n = 150; affected individuals aged 1–29 years) completed the CSBS-DP ITC. Distribution of scores indicated a floor effect. There was poor divergent validity for the three-factor model but goodness of fit and convergent validity data were satisfactory for the one-factor model. Individuals with poorer overall functional abilities scored lower on the CSBS-DP ITC. Test–retest reliability was excellent. The floor effect could explain the very high reliability, suggesting problems as a sensitive outcome measure in clinical trials for CDD.
HB11—Understanding Hydrogen-Boron Fusion as a New Clean Energy Source
Authors: McKenzie Warren , Batani Dimitri , Mehlhorn Thomas A. , Margarone Daniele , Belloni Fabio , Campbell E. Michael , Woodruff Simon , Kirchhoff Jan , Paterson Adrian , Pikuz Sergey , Hora Heinrich 
Published: May 2023

AbstractHB11 Energy’s mission is to realize large-scale electricity generation from the fusion of hydrogen with boron-11 (the HB11, or “proton-boron”, reaction) without the environmental problems normally associated with nuclear energy. A non-thermal approach is taken in the initiation of the reaction using high-peak-power lasers, which was the pursuit of HB11 Energy founder Prof. Heinrich Hora’s career as a theoretical physicist. In the 1980s, the invention of Chirped Pulse Amplification (CPA) of laser pulses by Donna Strickland and Gerard Mourou (Nobel Prize 2018) enabled the possibility of experimentally validating the earlier theoretical predictions. Several experimental demonstrations of the HB11 reaction using CPA lasers inspired the establishment of HB11 Energy and with it, the possibility of realizing an aneutronic nuclear energy source with easily accessible and safe fuel resources that could last thousands of years. Like all quests for fusion energy, there are significant scientific challenges remaining. HB11 Energy Holdings Pty Ltd, an Australian company, was established as the best vehicle to co-ordinate a global collaborative research effort to address these challenges and build capacity to host large-scale public private partnerships, such as those now recommended by the US National Academies of Science, Engineering and Medicine (NASEM) (US National Academies of Sciences, Engineering and Medicine in Bringing Fusion to the U.S. Grid,: National Academies Press, Washington, D.C, 2021). If net-energy-gain can be achieved through HB11 Energy’s concepts, there are many engineering benefits over traditional DT fusion that will see a dramatically simpler and safer reactor being produced. A technoeconomic assessment of such a reactor is also discussed which presents many engineering challenges that will need to be met before commercial HB11 fusion can be deployed on a large-scale.
Using the Corner Reflection for Depth Evaluation of Surface Breaking Cracks in Concrete by Ultrasound
Authors: Rabe Ute , Pudovikov Sergey , Herrmann Hans-Georg , Wiggenhauser Herbert , Prabhakara Prathik , Niederleithinger Ernst 
Published: May 2023

AbstractThe corner echo is a well-known effect in ultrasonic testing, which allows detection of surface breaking cracks with predominantly perpendicular orientation to the surface as, for example, corrosion cracks in metal pipes or shafts. This echo is formed by two planes, the surface of the crack and the surface which the crack breaks. It can also be classified as a half-skip method, since a reflection of the pulse occurs on the backwall before the reflection at the defect takes place. In combination with the diffraction from the crack tip, the corner echo also allows crack sizing. As shown in this paper, the corner reflection can be used in civil engineering for nondestructive inspection of concrete. Commercially available low frequency ultrasonic arrays with dry point contact sources generate SH transversal waves with sufficient divergence of the sound field in order to detect corner reflections. Ultrasonic line-scans and area-scans were acquired with a linear array on flat concrete specimens, and the data were reconstructed by the Synthetic aperture focusing technique. If the angles and the area of reconstruction are chosen accordingly, the corner echo reflection can be distinguished from other ultrasonic information. The corner echo can thus be used as a method for deciding whether a crack is a partial-depth crack or a full-depth crack and thus for obtaining a statement about crack depth. This paper presents corresponding experimental results obtained on concrete specimens with artificial test defects and cracks induced under controlled conditions.
English Grammar Skills in Dutch Grade 4 Children: Examining the Relation Between L1 and L2 Language Skills
Authors: van Koert Margreet , Leona Nihayra , Rispens Judith , Tijms Jurgen , Molen Maurits van der , Grunberg Hernán Labbé , Snellings Patrick 
Published: May 2023

AbstractSecond language proficiency may be related to first language acquisition (Ganschow & Sparks, 1991), but relatively little is known about the relation between first and second language grammatical proficiency in primary school children who are in their first stages of foreign language learning. This study aims to determine whether differences in Dutch and English vocabulary and Dutch grammar skills predict differences in English grammatical proficiency in Dutch speaking children who are in grade 4 in primary school. The selected participants are monolingual Dutch pupils (N = 152), aged 9;0–10;0. To measure the children’s vocabulary the PPVT was used in Dutch (Schlichting, 2005) and in English (Dunn & Dunn, 2007). In addition, two grammar tasks in English and one in Dutch of the CELF (Semel et al., 2003) were used. The results show that English vocabulary is a strong predictor of English grammar skills, and that the Dutch vocabulary skills are weaker predictors of English grammar skills. Moreover, Dutch grammar skills predict English grammar skills for one of the grammar tasks. These results are discussed vis-à-vis hypotheses about cross-domain transfer and cross-linguistic transfer (Blom et al., 2012; Cummins, 1979; Ganschow & Sparks, 1991; Paradis, 2011; Sparks, 1995).
The Enhancing Role of Emotion Regulation in the Links between Early Positive Memories and Self-harm and Suicidal Ideation in Adolescence
Authors: Carvalho Célia Barreto , Teixeira Marco , Costa Rodrigo , Cordeiro Filipa , Cabral Joana Moura 
Published: May 2023

AbstractAdolescence is a critical developmental period associated with an increased variety of interrelated risks and vulnerabilities. Previous studies have found associations between early memories of warmth and safeness, as well as emotion regulation, and self-harm and suicidal ideation in adolescence. Additionally, these early emotional memories have been found to be positively linked with some indicators of emotion regulation during this period. The present cross-sectional study extends prior research by exploring the moderating role of emotion regulation in the relationships between early memories of warmth and safeness, as well as each of the following risk-related outcomes in adolescence, in younger (i.e., 13–15) and older (i.e., 16–19) adolescents: suicidal ideation and self-harm and its associated functions (i.e., automatic and social reinforcement. Three self-report measures of these early emotional memories, emotion regulation, and risk-related outcomes, and a sample of 7918 Portuguese adolescents (53.3% females), with ages ranging from 13 to 19 (Mage = 15.5), were used. In both age groups, at high levels of emotion regulation, early memories of warmth and safeness had a greater (negative) effect on suicidal ideation and the automatic reinforcement function of self-harm, compared to at average and low levels of emotion regulation. These findings highlight the enhancing role of emotion regulation on the associations between early memories of warmth and safeness and some risk-related outcomes in adolescents, both younger and older, which reveals the relevance of targeting emotion regulation when preventing or tackling these outcomes, regardless of adolescents’ levels of early memories of warmth and safeness.
Determinants of intra-board behavioral integration in high-tech start-ups
Authors: Bjørnåli Ekaterina , Asad Sarosh , Terjesen Siri 
Published: May 2023

AbstractThe board of directors’ behavioral dynamics can strongly influence an entrepreneurial firm’s success. Drawing on the behavioral theory of corporate governance, this study identifies and tests factors that facilitate behavioral integration in boards of high technology start-ups. We unpack the black box of board behavior with primary data collected from a survey-based sample of 149 CEOs of Norwegian high-tech start-ups supplemented by quantitative archival information. We find that intra-board behavioral integration (i.e., board members’ propensity to clearly understand one another’s issues and needs, actively solve, and share relevant information and resources) is positively affected by greater levels of informal communication between CEOs and board members. Next, we find that inter-board trust (i.e., board members interact with absolute integrity, tell the truth at meetings, trust one another, and keep mutual promises) mediates this relationship such that higher levels of inter-board trust result in greater concordance between information communication frequency and inter-board behavioral integration. We then examine the role of an efficacious board chair who motivates and uses each board member’s competence, formulates proposals for decisions and summarizes conclusions after board negotiation, and chairs board discussions without promoting their agenda, finding that efficacious board chair leadership moderates the relationship between informal communication frequency and intra-board trust. We discuss the implications of these findings for the theory and practice.