bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propensity Score Matching Analysis for Alcohol‐Related Liver Disease
Authors: Duan Fangfang , Song Shanshan , Zhai Hang , Wang Yazhi , Cheng Jun , Yang Song 
Published: January 2025

ABSTRACTObjectivesThis study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol‐related liver disease (ARLD).MethodsPatients with ARLD and those with ARLD co‐morbid with CHB were included in this study and designated as the ARLD group and the ARLD + HBV group, respectively. Propensity score matching (PSM) was then employed to compare survival rates and liver cancer development between these two groups.ResultsAmong the 404 patients, 254 were in the ARLD group and 150 in the ARLD + HBV group. After propensity score matching, each group comprised 67 patients. Initially, the ARLD + HBV group exhibited lower 5‐year survival rates compared to the ARLD group (51.3% vs. 70.1%, p < 0.001). However, PSM mitigated this difference, with survival rates now comparable (61.2% vs. 60.9%, p = 0.390). Notably, the ARLD + HBV group showed a higher incidence of liver‐specific mortality after matching (32.6% vs. 6.2%, p = 0.018). Furthermore, although a higher proportion of patients in the ARLD + HBV group developed liver cancer post‐matching, the difference was not statistically significant compared to the ARLD group (15.7% vs. 9.8%, p = 0.170).ConclusionCo‐morbidity with CHB in ARLD patients elevates the risk of liver‐related mortality.
A Review on the Role of Human Solute Carriers Transporters in Cancer
Authors: Hossen Md. Shafiul , Islam Mohammed Shafin Ul , Yasin Mohammad , Ibrahim Mohammed , Das Abhijit 
Published: January 2025

ABSTRACTBackground and AimThe high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer.MethodsWe retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE regarding the influence of human SLCs on the development of cancer. Articles published in English before August 2024 were included in the study.ResultsThe overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response.ConclusionThe review recognized the crucial role of SLC transporters in different types of cancer progression. Therefore, to confirm our findings, a case‐control study is required to investigate the role of amino acid transporters in cancer development.
Horizontal Magnetic Field Influence on Fluid Flow Across a Variable Thickness Rotating Disk With Stretching and Melting Phenomenon
Authors: Rauf Amar , Ramesh Gosikere Kenchappa , Fatima Syeda , Shehzad Sabir Ali , Madhukesh Javali Kotresh , Siddiq Muhammad Kamran 
Published: January 2025

ABSTRACTAn incompressible steady‐state flow of viscous fluid subjected to a variable thickness rotating surface is examined. The laminar flow stream is also affected by the disk stretching. A horizontal magnetic field is applied along the disk to stabilize the flow dynamics depending on its orientation and strength. The implication of a horizontal magnetic field is also effective in regulating the thermal energy in high‐temperature environments such as turbines and nuclear reactors. The thermal features are also characterized by thermal radiation and melting heating. The melting phenomenon is useful in phase‐change materials for efficient thermal storage and release like polymer molding or metal casting. Similarity transformations that account for the variable thickness of the disk surface are utilized to dimensionalize the flow equations and to obtain a self‐similar solution. The numerical scheme Runge‐Kutta‐Fehlberg (RKF‐45) built‐in package is used for the solution of the normalized flow model. The salient nature of the physical parameters is illustrated in the momentum and thermal fields. The numerical data on skin‐friction coefficient and local Nusselt number at the stretchable surface is also calculated. The graphical results indicate that the flow and temperature profiles are strongly influenced by the physical parameters under consideration. It can be deduced that melting decreases the fluid resistance close to the surface, reducing drag, and in turn increasing flow velocity. The latent energy absorbed during the melting process reduces the effective thermal energy into the fluid that reduces the temperature gradients in the thermal boundary layer flow. The stabilizing effect of the horizontal magnetic field on the flow phenomenon along the radial direction is observed for the angle varying from 0 to 30 degrees. It is seen that the dimensionless radius facilitates the thermal transport phenomenon from the disk surface to the fluid, thus resulting in reduction of the thermal field.
Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions
Authors: Wang Yunge , Ma Xueping , Zhang Tao , Wang Lingfei , Liu Yunlong , Zhou Guohua , Wu Haiping 
Published: January 2025

AbstractCervical cancer is one of the most common malignant tumors that seriously threaten women's health. Persistent infection with high risk human papillomavirus (HPV) is closely related to the progression of cervical cancer. Cervical cancer screening is an effective measure to reduce the incidence and mortality of cervical cancer. The two most common screening strategies are cytology and HPV testing, but they easily lead to missed diagnosis or overdiagnosis. To overcome such limitations, a new triage method needs to be explored. The World Health Organization second edition guideline includes DNA methylation testing as a new method to be evaluated. DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. In recent years, many methylated genes have been found to be biomarkers for cervical cancer and precancerous lesions diagnosis. In this paper, we focus on the role and application of host DNA methylation, HPV DNA methylation, as well as combined host and HPV DNA methylation in the screening of cervical cancer and precancerous lesions.
Novel Foamed Magnesium Phosphate Antimicrobial Bone Cement for Bone Augmentation
Authors: Chen Jie , Cheng Ziqing , Wang Jiawen , Ding Huifen , Wang Kai , Deng Ping , Xu Ling , Huang Jiao 
Published: January 2025

ABSTRACTIn dental implant surgery, infection is identified as the primary factor contributing to the failure of bone grafts. There is an urgent need to develop bone graft materials possessing antibacterial characteristics to facilitate bone regeneration. Magnesium phosphate bone cement (MPC) is highly desirable for bone regeneration due to its favorable biocompatibility, plasticity, and osteogenic capabilities. However, the limited porosity of conventional MPC hinders the nutrient supply, gas diffusion, and cell infiltration, thereby compromising its osteogenic efficacy. This research focused on the fabrication of a highly porous MPC (CaCO3/CA‐MPC) by incorporating citric acid (CA) and calcium carbonate (CaCO3) as foaming agents. The resulting material demonstrated enhanced physicochemical properties, bioactivity, and antimicrobial effects. When compared with conventional MPC, human periodontal ligament stem cells (hPDLSCs) showed improved osteogenic differentiation when cultured with CaCO3/CA‐MPC. The inclusion of foaming agents significantly enhanced the antimicrobial efficacy of MPC against both Gram‐positive bacteria (Staphylococcus aureus) and Gram‐negative bacteria (Escherichia coli). The results of in vivo anti‐infection experiments in rats revealed that 3%CaCO3/CA‐MPC displayed superior bactericidal activity compared with Bio‐Oss and control groups (p < 0.05), thereby enhancing the anti‐infective outcomes post‐bone grafting and stimulating osteogenesis in the infected bone defect region. The study demonstrated that MPC containing 3%CaCO3/CA exhibited excellent antimicrobial and osteogenic properties both in vitro and in vivo, suggesting its potential as a promising candidate as bone graft material for dental implant surgeries.
A Theoretical Study on Crossings Among Electronically Excited States and Laser Cooling of Group VIA (S, Se, and Te) Hydrides
Authors: Li Donghui , Fayyaz Faiza , Bian Wensheng 
Published: January 2025

ABSTRACTVarious electronically excited states and the feasibility of direct laser cooling of SH, SeH, and TeH are investigated using the highly accurate ab initio and dynamical methods. For the detailed calculations of the seven low‐lying Λ‐S states of SH, we utilized the internally contracted multireference configuration interaction approach, considering the spin‐orbit coupling (SOC) effects. Our calculated spectroscopic constants are in very good agreement with the available experimental results. It is found that, from SH to TeH, the crossing points among the A2Σ+ and three electronically excited states gradually shift downward toward the ground vibrational level of the A2Σ+ state. This is consistent with our previous findings in other molecular systems and makes the laser cooling of TeH unfeasible. Our calculations indicate that the three crossing points, respectively, between the A2Σ+ and a4Σ−, A2Σ+ and B2Σ−, and A2Σ+ and b4Π states of SH, all lie above the v' = 1 vibrational level of the A2Σ+ state, as a result of which the crossings involving electronic states of higher energy would not hinder its laser cooling. Based upon our study on various excited states, we have constructed a viable laser‐cooling scheme for SH, utilizing three laser beams and leveraging the A2Σ+ → X2Π transition. This transition possesses a very large vibrational branching ratio R00 (0.9558), an abundant number of scattered photons (9.30 × 103), and a short radiative lifetime (787 ns). Our work underscores the important role of excited‐state crossings in molecular laser cooling and demonstrates that SH emerges as a very good candidate for ultracold molecules.
Linear or Cyclic? Theoretical Investigation of Astrophysically Relevant Magnesium‐Bearing MgCnH Carbon Chains and Related Isomers
Authors: Gomes A. Karolyna M. S. , Oliveira Ricardo R. , Cardozo Thiago M. , Fantuzzi Felipe 
Published: January 2025

ABSTRACTMagnesium‐containing molecules, including MgC2H, MgC4H, and MgC6H, have been detected in the interstellar medium, largely facilitated by their high dipole moments. However, despite great efforts, MgC2m + 1H species remain elusive. Given the challenges in obtaining experimental data for these molecules, theoretical studies play a crucial role in guiding their detection. In this work, we present a theoretical analysis of MgCnH isomers (n = 4–7) using density functional theory and coupled‐cluster methods to identify low‐lying isomers and characterize their structural and electronic properties. Our findings reveal that across the entire series investigated, the global minimum geometry is linear for even values of n, whereas for odd values, a cyclic geometry is favored. Additionally, our calculations highlight the enhanced stability of anionic MgCnH− systems, providing insights that could aid future astronomical detections in the interstellar medium.
Navigated instrumentation and ligament tensioning device enhances initial gap acquisition during total knee arthroplasty procedure: A cadaveric study
Authors: Boux de Casson François , Angibaud Laurent , Kerveillant Florian , Nogaret Faustine , Ruffin Joris , Duporté Léonard , Giordano Gérard , Dagneaux Louis 
Published: January 2025

AbstractPurposeGap‐balanced total knee arthroplasty (TKA) technique relies on initial ligament evaluation, particularly in patient‐specific implantation using computer‐assisted technologies. This cadaveric study aimed to compare the reproducibility and reliability of medial and lateral gap measurements between manual stress testing and dynamic ligament balancer.MethodsInitial gap acquisitions were assessed from eight cadaveric knees (four specimens) during the same navigated TKA procedure by five differently skilled surgeons (three seniors and two juniors). Medial and lateral gaps were sequentially acquired from extension to maximum knee flexion, applying manual stress prior to any bone cuts (conventional technique), and using intra‐articular tensioning device placed between the tibial cut and the native femur (instrumented technique). Reproducibility was assessed using intraclass correlation coefficient (ICC), stratified by the measurement technique, the type of gaps and the operator experience. Differences in gaps (mm) between techniques were assessed using the Bland and Altmann method.ResultsThe instrumented technique showed higher ICCs than the conventional technique for medial and lateral gaps (0.87 vs. 0.60, P = 0.002, and 0.92 vs. 0.25, p < 0.0001, respectively), and showed no difference in ICCs between medial and lateral gap acquisitions (0.87 vs. 0.92, p = 0.8). Senior surgeons achieved higher ICCs than juniors, while non‐significant with both techniques. Differences in gaps between techniques increased with knee flexion angle (0.8, 2.8 and 3.5 mm at 10°, 45° and 90° of flexion angle, respectively) and decreased with the operator experience (p = 0.003).ConclusionThe instrumented balancing technique offered better reproducibility than using manual valgus and varus stress, when measuring medial and lateral gaps. Tensioning devices may play a significant role in enhancing initial gap acquisition, disregarding the flexion angle and the operator experience.Level of EvidenceLevel IV (observational study involving cadaveric specimens).
Chronic enrichment affects nitrogen removal in tidal freshwater river and estuarine creek sediments
Authors: Smiley Anne Margaret H. , Thompson Suzanne P. , Piehler Michael F. 
Published: January 2025

AbstractPopulation growth in coastal areas increases nitrogen inputs to receiving waterways and degrades water quality. Wetland habitats, including floodplain forests and marshes, can be effective nitrogen sinks; however, little is known about the effects of chronic point source nutrient enrichment on sediment nitrogen removal in tidally influenced coastal systems. This study characterizes enrichment patterns in two tidal systems affected by wastewater treatment facility (WWTF) effluent and assesses the impact on habitat nitrogen removal via denitrification. We collected intact sediment cores from prevalent habitats in a tidal freshwater river (TFZ; swamp forest) and a tidal estuarine creek system (EST; salt marsh) upstream and downstream of a WWTF outfall, and quantified dissolved gas fluxes across the sediment‐water interface during wet conditions in early summer and dry conditions in late summer. Data collected during two synoptic water quality monitoring campaigns complimented laboratory experiments to provide environmental context for biogeochemical processing. The two systems exhibited different enrichment patterns such that the river‐dominated TFZ system was characterized by consistently elevated nitrate + nitrite concentrations downstream of the WWTF, whereas precipitation and tidal influence affected nutrient distributions in the EST creek. Downstream sediments in TFZ exhibit an apparent saturation response, while upstream rates may be limited by other factors, such as labile organic matter availability. In contrast, downstream sediments in EST denitrify at higher rates than upstream during wet conditions that may enhance transport of effluent. This work provides information on ecosystem functioning in human‐influenced environments and can be of use in developing nature‐based solutions, such as water treatment wetlands, for nitrogen removal.
ECB‐WQ: A Long‐Term Agroecosystem Research (LTAR)—Eastern Corn Belt node field‐scale water quality dataset
Authors: King Kevin W. , Williams Mark R. , Bos Janae , Rumora Kathryne , Stinner Jedediah 
Published: January 2025

AbstractThe Eastern Corn Belt (ECB) node of the Long‐Term Agroecosystem Research (LTAR) network is representative of row crop agricultural production systems in the poorly drained, humid regions of the US Midwest and a significant focus for addressing water quantity and quality concerns affecting Lake Erie and the Gulf of Mexico. The objectives of this paper were to (1) present relevant background information and collection methodology, (2) provide summary analyses of measured data, and (3) provide details for accessing the dataset and discuss potential database applications. The ECB‐water quality (ECB‐WQ) database is comprised of hydrology and water quality data from three privately owned farms in Northwest Ohio and Northeast Indiana and is available for download through the United States Department of Agriculture Ag Data Commons. The dataset includes information on site characteristics (drainage area and soil type), field management (fertilizer application, planting rate, and yield), and daily discharge and measured nutrient concentrations from surface and subsurface tile drainage outlets. Discharge and water quality vary widely across the ECB and are paramount to developing innovative management strategies that balance crop production goals with environmental targets. Discharge is generally greater from subsurface tile drainage compared to surface runoff. Phosphorus concentrations are typically greater in the surface runoff compared to tile drainage, while nitrogen concentrations are greater in subsurface tile drainage. The ECB‐WQ database was developed to better facilitate understanding of water quantity and quality within this unique, systematic, artificially tile‐drained region and is critical for understanding implications of field management practices, quantifying environmental and production processes, constraining hydrology/water quality models, and informing future water quality policies.
Anatomical dissection influences emotions of podiatry students
Authors: Mohedano‐Moriano Alicia , Romo‐Barrientos Carmen , Flores‐Cuadrado Alicia , Ubeda‐Bañon Isabel , Gonzalez‐Gonzalez Jaime , Gil Ruiz Maria Teresa , Saiz‐Sanchez Daniel , Astillero‐Lopez Veronica , Marcos‐Tejedor Felix , Martinez‐Marcos Alino , Viñuela Antonio , Criado‐Alvarez Juan Jose 
Published: January 2025

AbstractBackgroundDissection and examination of prosected cadavers is a tool for teaching anatomy. However, this experience can provoke anxiety and stress among students. This study aims to understand the attitudes, reactions, fears, and anxiety states of podiatry students before their first dissection in addition to evaluate its usefulness as an educational tool for academic training in anatomy.MethodsA cross‐sectional study was carried out before and after the dissection room visit of first‐year podiatry students. They were given several questionnaires: State‐Trait Anxiety Inventory questionnaires (STAI‐state anxiety and STAI‐trait anxiety) and two anonymous questionnaires.ResultsLevels of total emotional anxiety (STAI‐state anxiety) decreased significantly (p < 0.05) from 16.9 points before practice to 10.9 points after practice. In terms of gender, significant differences (p < 0.05) were observed in anxiety levels before and after practice. However, female students had significantly (p < 0.05) higher pre‐practice levels of STAI‐state anxiety than male students.ConclusionsAlthough 100% of students (3.98 ± 0.149, over 4) expressed satisfaction with the practical's dissection and considered that these contributed significantly to the consolidation of their anatomical knowledge, the experience generated emotional responses that need to be addressed. Higher levels of anxiety were observed among female students, highlighting the need to implement effective coping mechanisms to mitigate emotional reactions, with special emphasis on this population.
Influence of endoscopic sphincterotomy on hepatolithiasis with Oddi sphincter‐preserved cholangioplasty with hepatico‐subcutaneous stoma: A three‐decade, real word cohort study
Authors: Yu Xue , Zhang Jie , Zhang Yunyi , Zhao Xiaoyu , Xu Zhi , Wang Lixin , Hou Chunsheng , Zhang Lingfu , Ling Xiaofeng 
Published: January 2025

AbstractBackgroundHepatolithiasis frequently presents with recurring cholangitis and complications. Oddi sphincter‐preserved cholangioplasty with hepatico‐subcutaneous stoma (OSPCHS), introduced in 1993, has shown favorable long‐term results. Endoscopic sphincterotomy (EST) is commonly used, but its impact on OSPCHS outcomes remains unclear.MethodsFrom January 1993 to June 2021, 254 patients with hepatolithiasis underwent OSPCHS. A total of 31 patients had prior EST (group with EST, n = 31), while 223 did not (group without EST, n = 223). Perioperative and long‐term outcomes were compared, and risk factors for stone and cholangitis recurrence were analyzed using a Cox regression model.ResultsThe immediate and final stone clearance rates were 67.3% and 81.9%, respectively. Patients with prior EST had higher rates of stone recurrence (57.7% vs. 35.7%, p = .031), shorter stone‐free duration (median: 51.5 vs. 112.0 months, p = .001), higher cholangitis recurrence (45.2% vs. 25.6%, p = .023), and shorter cholangitis‐free duration (median: 71.0 vs. 134.0 months, p = .006). Multivariable analysis identified bilateral intrahepatic stones (HR: 1.815, p = .010) and prior EST (HR: 3.157, p = .000) as independent risk factors for stone recurrence, whereas combined hepatectomy was a protective factor (HR: 0.448, p = .001). For cholangitis recurrence, male gender (HR: 2.308, p = .001) and EST (HR: 2.241, p = .009) were independent risk factors, while complete stone clearance reduced recurrence risk (HR: 0.423, p = .002).ConclusionPrior EST adversely affects the long‐term outcomes of OSPCHS. Therefore, in the management of hepatolithiasis, emphasis should be placed on preserving the Oddi sphincter.
Modulation of Cell Cycle Kinases by Kaposi's Sarcoma‐Associated Herpesvirus
Authors: Longworth Steven , Damania Blossom 
Published: January 2025

ABSTRACTThe cell cycle is governed by kinase activity that coordinates progression through a series of regulatory checkpoints, preventing the division of damaged cells. The Kaposi's sarcoma‐associated herpesvirus (KSHV) encodes multiple genes that modulate or co‐opt the activity of these kinases, shaping the cellular environment to promote viral persistence. By advancing the cell cycle, KSHV facilitates latent replication and subsequent transmission of viral genomes to daughter cells, while also contributing to the establishment of multiple cancer types. Conversely, during viral lytic replication, KSHV extends the resting phase of the cell cycle to prevent cellular DNA synthesis that would otherwise compete for essential replication precursors. This review will examine the mechanisms KSHV has evolved to control the kinase activity regulating host cell cycle progression.