bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Objectivist Attempt to Appropriate Subjective Value
Authors: Sobel David , Wall Steven 
Published: July 2023

Abstract
This chapter explores objectivist responses to the problem of mere taste—the appearance that, at least in such contexts, our unwarranted favoring attitudes play a normative role in determining our good. The chapter critiques objectivist responses that concede this appearance is correct, yet nonetheless maintain that this is compatible with a thoroughgoing objectivism. Some such objectivist responses make use of the “combo view” of the value-bearer—that is, they claim that it is not the object of the attitudes that have value but a combination of the object and the attitude. In responding to such objectivist arguments, the authors’ investigation sorts out the best understanding of the subjective/objective divide. The chapter is unique in sorting through several different such understandings and arguing for the authors’ own favored understanding. With a proper understanding of the divide, the above objectivist moves are revealed to be attempting to appropriate what is really subjective value.
Advancements and challenges in bamboo breeding for sustainable development
Authors: Sun Huayu , Wang Jiangfei , Li Hui , Li Tiankuo , Gao Zhimin 
Published: July 2023

Abstract
Bamboo is a highly renewable biomass resource with outstanding ecological, economic and social benefits. However, its lengthy vegetative growth stage and uncertain flowering period have hindered the application of traditional breeding methods. In recent years, significant progress has been made in bamboo breeding. While technical advances in bamboo breeding have been impressive, it is essential to also consider the broader implications we can learn from bamboo’s extraordinary features for sustainable development. This review provides an overview of the current status of bamboo breeding technology, including a detailed history of bamboo breeding divided into four eras, a comprehensive map of bamboo germplasm gardens worldwide, with a focus on China, and a summary of available transgenic technologies for gene function verification and genetic improvement. As the demand for bamboo as a sustainable and renewable resource increases continuously, breeding objectives should be focused on enhancing yield, wood properties and adaptability to diverse environmental conditions. In particular, priority should be given to improving fiber length, internode length and wall thickness, as well as regulating lignin and cellulose content for papermaking, substitute for plastic and other applications. Furthermore, we highlight the challenges and opportunities for future research and development in bamboo breeding, including the application of omics technologies, artificial intelligence and the development of new breeding methods. Finally, by integrating the technical advances in bamboo breeding with a discussion of its broader implications for sustainable development, this review provides a comprehensive framework for the development of bamboo industry.
Young adults with congenital heart disease heading to college: Are college health centers and providers prepared?
Authors: Hardy Rose Y. , Babu Suhas , Jackson Jamie L. , George Sandra , Andrews Jennifer G. , Daskalov Rachel , May Susan C. , Miller Paula , Timmins Susan , Pike Nancy A. ,   for the Congenital Heart Public Health Consortium
Published: July 2023

ABSTRACT

Background:
An estimated 1.4 million adults in the United States have congenital heart disease (CHD). As this population grows and many pursue postsecondary education, these adults' health care needs and concerns should be at the forefront for providers, particularly nurse practitioners, at college health centers.

Purpose:
To understand how college health centers and providers identify and manage the care of students with chronic conditions to further support their health care transition, with a focus on students with CHD.

Methodology:
Qualitative key informant interviews were performed with providers at five college health centers to understand the processes in place and the challenges health care providers on college campuses face when caring for students with CHD.

Results:
Most of the college health centers did not have formalized processes in place to care for these students. Although many felt that they had the capabilities in their health centers to manage these students' maintenance/preventive care needs, fewer felt comfortable with their urgent or emergent care needs. The onus was often on students or parents/guardians to initiate these transitions.

Conclusions:
This study highlights some challenges to providing care to students with chronic conditions like CHD. More collaborative relationships with specialists may be critical to ensuring that all the care needs of chronic disease students are met on college campuses.

Implications:
Nurse practitioners, who often staff these clinics, are well positioned to support this transition onto campuses and lead the development of processes to identify these students, ease care management transitions, and ensure easy provider communication that allow students with chronic diseases to thrive on campus.
Origami-based growing tube model for reproducing shell shapes
Authors: Ueda Maho , Fukunaga Nozomi , Yamashita Noa , Yokoyama Yuki , Kida Hideaki , Matsuda Keisuke 
Published: July 2023

AbstractMathematical models for shell morphology have been well-studied in theoretical morphology. The growing tube model proposed by Takashi Okamoto was developed to reproduce heteromorph ammonoids and can generate various shells by changing three parameters: curvature, torsion, and enlarging ratio. Previous studies in theoretical morphology have employed computers to visualize mathematical models. However, computers are not accessible to everyone, and merely observing the graphics of the reproduced shells does not deepen understanding of the mathematical model. Therefore, in this study, we considered using origami, which is inexpensive and readily available, to make users understand mathematical models through hands-on folding. First, we simplified the crease pattern of seashells, originally devised by an origami artist Tomoko Fuse, to create a basic crease pattern. We then identified the crease pattern elements corresponding to the three parameters in the growing tube model and the aperture-apex position determiner. Based on them, we reproduced various shell shapes, including a heteromorph-ammonoid-like shape, with origami. Finally, we investigated the constraints between parameters in the origami-growing tube model. The origami-growing tube model is expected to help disseminate mathematical models and promote theoretical biology.
ERK signalling orchestrates metachronous transition from naïve to formative pluripotency
Authors: Mulas Carla , Stammers Melanie , Salomaa Siiri I. , Heinzen Constanze , Suter David M. , Smith Austin , Chalut Kevin J. 
Published: July 2023

ABSTRACTNaïve epiblast cells in the embryo and pluripotent stem cellsin vitroundergo developmental progression to a formative state competent for lineage specification. During this transition, transcription factors and chromatin are rewired to encode new functional features. Here, we examine the role of mitogen-activated protein kinase (ERK1/2) signalling in pluripotent state transition. We show that a primary consequence of ERK activation in mouse embryonic stem cells is elimination of Nanog, precipitating breakdown of the naïve state gene regulatory network. Cell variability in pERK dynamics results in metachronous down-regulation of Nanog and naïve state exit. Knockdown of Nanog allows exit without ERK activation. However, transition to formative pluripotency does not proceed and cells collapse to an indeterminate identity. This failure is attributable to loss of expression of the central pluripotency factor Oct4. Thus, during formative transition ERK signalling both dismantles the naïve state and preserves pluripotency. These results illustrate that a single signalling pathway can both drive exit from a developmental state and safeguard progression to the successor state.
Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury
Authors: Yu Ziyang , Pang Huize , Yang Yifan , Luo Doudou , Zheng Haiping , Huang Zicheng , Zhang Mingxia , Ren Ke 
Published: July 2023

AbstractAimsAcute kidney injury (AKI) has been associated with a variety of neurological problems, while the neurobiological mechanism remains unclear. In the present study, we utilized resting‐state functional magnetic resonance imaging (rs‐fMRI) to detect brain injury at an early stage and investigated the impact of microglia on the neuropathological mechanism of AKI.MethodsRs‐fMRI data were collected from AKI rats and the control group with a 9.4‐Tesla scanner at 24, 48, and 72 h post administration of contrast medium or saline. The amplitude of low‐frequency fluctuations (ALFF) was then compared across the groups at each time course. Additionally, flow cytometry and SMART‐seq2 were employed to evaluate microglia. Furthermore, pathological staining and Western blot were used to analyze the samples.ResultsMRI results revealed that AKI led to a decreased ALFF in the hippocampus, particularly in the 48 h and 72 h groups. Additionally, western blot suggested that AKI‐induced the neuronal apoptosis at 48 h and 72 h. Flow cytometry and confocal microscopy images demonstrated that AKI activated the aggregation of microglia into neurons at 24 h, with a strong upregulation of M1 polarization at 48 h and peaking at 72 h, accompanying with the release of proinflammatory cytokines. The ALFF value was strongly correlated with the proportion of microglia (|r| > 0.80, p < 0.001).ConclusionsOur study demonstrated that microglia aggregation and inflammatory factor upregulation are significant mechanisms of AKI‐induced neuronal apoptosis. We used fMRI to detect the alterations in hippocampal function, which may provide a noninvasive method for the early detection of brain injury after AKI.
Significant reduction in diabetes distress and improvements in psychosocial outcomes: A pilot test of an intervention to reduce diabetes distress in adults with type 1 diabetes and moderate‐to‐severe diabetes distress (REDUCE)
Authors: Stenov Vibeke , Due‐Christensen Mette , Cleal Bryan Richard , Tapager Ingrid Willaing 
Published: July 2023

AbstractAimTo pilot‐test an intervention, co‐designed with people with type 1 diabetes (T1DM) and diabetes specialist nurses, to reduce diabetes distress (DD) in adults with T1DM and moderate‐to‐severe DD.MethodsA group‐based programme to reduce DD in people with T1DM and moderate‐to‐severe DD (REDUCE) was pilot‐tested in four groups with five bi‐weekly two and a half‐hour meetings facilitated by two trained diabetes specialist nurses. Data collection included baseline and post‐intervention questionnaires measuring DD and psychosocial outcomes and semi‐structured interviews with participants post‐intervention (n = 18). Data were analysed using descriptive statistics and systematic text condensation.ResultsTwenty‐five adults with T1DM participated in the study. The median age and diabetes duration of participants were 50 (IQR: 32;57.5) years and 26 (IQR: 18;45) years, respectively. Seventeen (68%) were women. The pilot study showed a significant reduction in DD (measured by Type 1 Diabetes Distress Scale) between baseline and post‐intervention from 2.6 ± 0.7 to 1.9 ± 0.6 (mean ± SD) (p < 0.001). The largest reductions were seen on the subscales: powerlessness 1.2 ± 1.1, eating distress 0.9 ± 1.2 and fear of hypoglycaemia 0.8 ± 1.0 (mean ± SD). Significant improvements were also seen for quality of life, diabetes empowerment and emotion regulation. Qualitative data showed that REDUCE supported participants in verbalizing emotions and seeing worries in a more constructive perspective. Acknowledgement of negative diabetes experiences eased negative self‐judgments. Sharing experiences among peers increased relatedness and reduced loneliness.ConclusionParticipation in REDUCE was associated with significant reduction in DD and significant increase in quality of life. Larger scale studies are planned to determine sustained effectiveness of REDUCE.
Effect of combined aerobic–resistance training and subsequent detraining on brain‐derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial
Authors: Donyaei Adel , Kiani Elina , Bahrololoum Hassan , Moser Othmar 
Published: July 2023

AbstractAimsIn this study, we assessed the effects of a 12‐week combined aerobic–resistance training and subsequent detraining on Beck Depression Inventory (BDI) score and mediating role of BDNF and also investigated whether exercise‐induced alterations are maintained following a short period of detraining in women with type 2 diabetes (T2D).Materials and MethodsThirty‐four women with T2D were randomly assigned to experimental or control group (age: 60.6 ± 6.3, body mass index (BMI): 30.2 ± 1.3 kg/m2, HbA1c: 8.09 ± 0.73%). The exercise training comprised of combined aerobic–resistance programme (50%–70% heart rate reserve for aerobic exercise, and 50%–70% 1 repetition maximum for resistance exercise, respectively) performed three sessions per week over 12 weeks. The intervention period was followed by an 8‐week detraining period. Data were collected at baseline and also following exercise intervention and detraining. Data were analysed by linear mixed model at p < 0.05.ResultsAfter 12 weeks of combined exercise training and 8 weeks of detraining, there was a significant difference in BDNF (0.08; 95% confidence interval [CI] = 0.07–0.10; p = 0.001), fasting blood glucose (FBG) (−45.41; CI = −50.83, ‐39.98; p = 0.001), insulin (−6.47; CI = −7.04, −5.9; p = 0.001), HOMA‐IR (−3.76; CI = −4.07, −3.45; p = 0.001) and BDI score (−17.17; CI = −20.29, −14.05; p = 0.001) between the experimental and control group. Multiple mediation analysis indicated that BDNF seems to have a mediating role in exercise‐induced improvement of depression (p = 0.04). After the detraining period, BDI score remained unchanged and it showed a significant increase compared to before the start of training (p = 0.001).ConclusionsIt may be concluded that exercise training improves depression that is likely to be explained by increased BDNF concentration in TD2. In spite of decreased BDNF concentration following an 8‐week detraining, depression score was maintained.
Diversity, Equity and Inclusion in the AIS: Challenges and opportunities of remote conferences
Authors: Marabelli Marco , Zaza Sam , Masiero Silvia , Li Jingyao (Lydia) , Chudoba Kathy 
Published: July 2023

AbstractWith this research opinion article, we aim to contribute to the ongoing conversation concerning diversity, equity and inclusion (DEI) within the IS community. Following Windeler et al.'s (2020) research on perceptions of DEI among members of the Association for Information Systems (AIS), we focus on how conferences should be convened in the post‐COVID‐19 era to maximise inclusivity. What are the benefits, challenges and implications of holding online and hybrid conferences? Informed by feedback from a survey involving IS scholars in the Global South and from a wide array of AIS senior scholars and conference leaders, we identify several challenges and opportunities of online and hybrid conferences (or, more generally, conferences allowing remote access) for the IS community. We weigh these tradeoffs and implications for DEI and provide reflections to generate constructive discussion on the future of AIS conferences.
The influence of loss to follow‐up in autism screening research: Taking stock and moving forward
Authors: Sheldrick R. Christopher , Hooker Jessica L. , Carter Alice S. , Feinberg Emily , Croen Lisa A. , Kuhn Jocelyn , Slate Elizabeth , Wetherby Amy M. 
Published: July 2023

BackgroundHow best to improve the early detection of autism spectrum disorder (ASD) is the subject of significant controversy. Some argue that universal ASD screeners are highly accurate, whereas others argue that evidence for this claim is insufficient. Relatedly, there is no clear consensus as to the optimal role of screening for making referral decisions for evaluation and treatment. Published screening research can meaningfully inform these questions—but only through careful consideration of children who do not complete diagnostic follow‐up.MethodsWe developed two simulation models that re‐analyze the results of a large‐scale validation study of the M‐CHAT‐R/F by Robins et al. (2014, Pediatrics, 133, 37). Model #1 re‐analyzes screener accuracy across six scenarios, each reflecting different assumptions regarding loss to follow‐up. Model #2 builds on this by closely examining differential attrition at each point of the multi‐step detection process.ResultsEstimates of sensitivity ranged from 40% to 94% across scenarios, demonstrating that estimates of accuracy depend on assumptions regarding the diagnostic status of children who were lost to follow‐up. Across a range of plausible assumptions, data also suggest that children with undiagnosed ASD may be more likely to complete follow‐up than children without ASD, highlighting the role of clinicians and caregivers in the detection process.ConclusionsUsing simulation modeling as a quantitative method to examine potential bias in screening studies, analyses suggest that ASD screening tools may be less accurate than is often reported. Models also demonstrate the critical importance of every step in a detection process—including steps that determine whether children should complete an additional evaluation. We conclude that parent and clinician decision‐making regarding follow‐up may contribute more to detection than is widely assumed.
Association between physicians' geriatric training and patterns of end‐of‐life care delivered to persons with dementia
Authors: Gotanda Hiroshi , Zhang Jessica J. , Reuben David B. , Walling Anne M. , Xu Haiyong , Jena Anupam B. , Gross Nate , Tsugawa Yusuke 
Published: July 2023

AbstractBackgroundGeriatric training is designed to prepare physicians to meet the complex needs of older adults, including persons with dementia at the end‐of‐life (EOL) stage. We sought to compare patterns of EOL care delivered to persons with dementia between physicians with versus without geriatric training.MethodsWe conducted a cross‐sectional study of a 20% random sample of fee‐for‐service Medicare beneficiaries with dementia who died in 2016–2018 (n = 99,631). We attributed beneficiaries to a physician who had the largest number of primary care visits during the last 6 months of life and determined whether the physician was trained in geriatrics. Our outcome measures included: (i) advance care planning (ACP) and palliative care (e.g., ACP, hospice enrollment in the last 90 days of life), and (ii) high‐intensity EOL care (e.g., emergency department visits or hospital admissions in the last 30 days of life).ResultsBeneficiaries with dementia under the care of physicians with geriatric training had a higher proportion of ACP (adjusted proportion, 15.8% vs. 13.0%;p < 0.001 after accounting for multiple comparisons), palliative care counseling (22.4% vs. 20.9%;p = 0.01), and hospice enrollment (63.7% vs. 60.6%;p < 0.001). Geriatric training was also associated with a lower proportion of emergency department visits (55.1% vs. 59.1%;p < 0.001), hospital admissions (48.8% vs. 52.3%;p < 0.001), ICU admissions (24.9% vs. 27.4%;p < 0.001), use of mechanical ventilation (11.2% vs. 13.0%;p < 0.001), and use of cardiopulmonary resuscitation (2.1% vs. 2.4%;p = 0.03) in the last 30 days of life. There was no evidence that the placement of feeding tubes differed between the two groups.ConclusionsPhysicians' geriatric training was associated with the receipt of more ACP and palliative care and less intensive EOL care among persons with dementia. Provision of geriatric training for physicians may have the potential to improve the quality of EOL care delivered to persons with dementia.
Serotonergic regulation of appetite and sodium appetite
Authors: Shin Yurim , Kim Seungjik , Sohn Jong‐Woo 
Published: July 2023

AbstractSerotonin is a neurotransmitter that is synthesized and released from the brainstem raphe nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic neurons is changed in response to the changes in feeding status to regulate appetite via the serotonin receptors. Likewise, changes in volume status are known to alter the activity of raphe serotonergic neurons and drugs targeting serotonin receptors were shown to affect sodium appetite. Therefore, the central serotonin system appears to regulate ingestion of both food and salt, although neural mechanisms that induce appetite in response to hunger and sodium appetite in response to volume depletion are largely distinct from each other. In this review, we discuss our current knowledge regarding the regulation of ingestion – appetite and sodium appetite – by the central serotonin system.
A comprehensive item‐level examination of Conscientiousness' underlying structure across three large samples
Authors: Phillips Nathaniel L. , Van Til Kaela , Lynam Donald R. , Miller Joshua D. 
Published: July 2023

AbstractObjectiveThe present study examined the hierarchical structure of Conscientiousness across three large samples using item‐level analyses.BackgroundConscientiousness is among the strongest predictors of individual differences in major life outcomes. Yet decades of work understanding the optimal lower‐order structure of Conscientiousness has not rectified the differences that remain among existing models and measures. To precisely measure its relations to major life outcomes, it is necessary to work toward a comprehensive, replicable conceptualization of the construct's structure.MethodsThe present pre‐registered study used three samples (Ns = 446, 406, & 424) to explore the domain's latent structure with item‐level “bass‐ackward” factor analyses and evaluate the resulting structure's interpretability, parsimony, and replicability. Participants completed self‐report measures of Conscientiousness and criteria in its nomological network (e.g., FFM traits, externalizing behavior, disinhibitory traits; informant reports were collected as well).ResultsThe factor analyses identified five interpretable and replicable factors (i.e., deliberation, order, industriousness, self‐discipline, and dependability) using predominant measures of general personality. An additional factor (i.e., traditionalism) was introduced in the six‐factor solution when the item pool was expanded to include less widely used measures of general personality.ConclusionThe authors discuss the item composition of each factor, their relation to existing models and measures of the domain's structure, their association with relevant criteria, and the general implications of conceptualizing Conscientiousness using flexible, item‐level factor analysis.