bluuebunny/crossref_metadata_2025_split huggingface dataset:
A voluntary-sector meeting place as a site for interpreting and ‘doing’ integration: a case of later-life Russian-speaking migrants
Authors: Asikainen Anastasia 
Published: June 2023

AbstractWhile a great deal of research has been conducted on implications of integrative policies targeted at migrants, later-life migrants and their relational and spatial negotiations and enactments of the policy-driven discourse of integration, and the dynamics under which it is interpreted remains understudied. Older migrants are presented as ‘special cases’ in the Finnish integration policy and are discussed mainly in relation to their social and health care needs. Integration is the model and aim for migrant settlements in Finland, however the aim to integrate possesses intrinsic value. Therefore, they need to make sense of what integration is for them in their everyday lives. This paper focuses on the interpretations and mundane enactments of ‘integration’ in a voluntary sector-organised meeting place for later-life Russian-speaking migrants in Finland. By comparing the views of different actors within the meeting place (steering group, organisers and attendees), the paper presents a nuanced understanding of the dynamics under which the later-life migrants negotiate their positions in the Finnish community of value, vis-à-vis the expectations of integration. The paper argues that ‘doing integration’ as a category of practice is an emergent feature in places where it is possible to negotiate integration as a lived experience. Drawing from participant observations, interviews, and applications and reports gathered in a meeting in the capital region of Finland, the paper foregrounds the lived and contested experiences of finding a sense of belonging in dialogue with the omnipresent discourse of integration. The paper concludes that the interpretations of the policy-driven discourse of integration are context-bound and negotiated in a set of relationships.
First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
Authors: Handula Maryana , Beekman Savanne , Konijnenberg Mark , Stuurman Debra , de Ridder Corrina , Bruchertseifer Frank , Morgenstern Alfred , Denkova Antonia , de Blois Erik , Seimbille Yann 
Published: June 2023

Abstract
Background
The [177Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist, [177Lu]Lu-DOTA-JR11, that demonstrated better biodistribution profile and higher tumor uptake than [177Lu]Lu-DOTA-TATE. Furthermore, treatment with alpha emitters showed improvement of the therapeutic index of PRRT due to the high LET offered by the alpha particles compared to beta emitters. Therefore, [225Ac]Ac-DOTA-JR11 can be a potential candidate to improve the treatment of NETs (Graphical abstract). DOTA-JR11 was radiolabeled with [225Ac]Ac(NO3)3 and [177Lu]LuCl3. Stability studies were performed in phosphate buffered saline (PBS) and mouse serum. In vitro competitive binding assay has been carried out in U2OS-SSTR2 + cells for natLa-DOTA-JR11, natLu-DOTA-JR11 and DOTA-JR11. Ex vivo biodistribution studies were performed in mice inoculated with H69 cells at 4, 24, 48 and 72 h after injection of [225Ac]Ac-DOTA-JR11. A blocking group was included to verify uptake specificity. Dosimetry of selected organs was determined for [225Ac]Ac-DOTA-JR11 and [177Lu]Lu-DOTA-JR11.

Results
[225Ac]Ac-DOTA-JR11 has been successfully prepared and obtained in high radiochemical yield (RCY; 95%) and radiochemical purity (RCP; 94%). [225Ac]Ac-DOTA-JR11 showed reasonably good stability in PBS (77% intact radiopeptide at 24 h after incubation) and in mouse serum (~ 81% intact radiopeptide 24 h after incubation). [177Lu]Lu-DOTA-JR11 demonstrated excellent stability in both media (> 93%) up to 24 h post incubation. Competitive binding assay revealed that complexation of DOTA-JR11 with natLa and natLu did not affect its binding affinity to SSTR2. Similar biodistribution profiles were observed for both radiopeptides, however, higher uptake was noticed in the kidneys, liver and bone for [225Ac]Ac-DOTA-JR11 than [177Lu]Lu-DOTA-JR11.

Conclusion
[225Ac]Ac-DOTA-JR11 showed a higher absorbed dose in the kidneys compared to [177Lu]Lu-DOTA-JR11, which may limit further studies with this radiopeptide. However, several strategies can be explored to reduce nephrotoxicity and offer opportunities for future clinical investigations with [225Ac]Ac-DOTA-JR11.
Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications
Authors: Zhang Weiyue , Huang Xin 
Published: June 2023

AbstractStem cell-based therapy is widely accepted to be a promising strategy in tissue regenerative medicine. Nevertheless, there are several obstacles to applying stem cells in skin regeneration and wound healing, which includes determining the optimum source, the processing and administration methods of stem cells, and the survival and functions of stem cells in wound sites. Owing to the limitations of applying stem cells directly, this review aims to discuss several stem cell-based drug delivery strategies in skin regeneration and wound healing and their potential clinical applications. We introduced diverse types of stem cells and their roles in wound repair. Moreover, the stem cell-based drug delivery systems including stem cell membrane-coated nanoparticles, stem cell-derived extracellular vesicles, stem cell as drug carriers, scaffold-free stem cell sheets, and stem cell-laden scaffolds were further investigated in the field of skin regeneration and wound healing. More importantly, stem cell membrane-coating nanotechnology confers great advantages compared to other drug delivery systems in a broad field of biomedical contexts. Taken together, the stem cell-based drug delivery strategy holds great promise for treating skin regeneration and wound healing.
The REBURN model: simulating system-level forest succession and wildfire dynamics
Authors: Prichard Susan J. , Salter R. Brion , Hessburg Paul F. , Povak Nicholas A. , Gray Robert W. 
Published: June 2023

AbstractBackgroundHistorically, reburn dynamics from cultural and lightning ignitions were central to the ecology of fire in the western United States (wUS), whereby past fire effects limited future fire growth and severity. Over millennia, reburns created heterogenous patchworks of vegetation and fuels that provided avenues and impediments to the flow of future fires, and feedbacks to future fire event sizes and their severity patterns. These dynamics have been significantly altered after more than a century of settler colonization, fire exclusion, and past forest management, now compounded by rapid climatic warming. Under climate change, the area impacted by large and severe wildfires will likely increase — with further implications for self-regulating properties of affected systems. An in-depth understanding of the ecology of reburns and their influence on system-level dynamics provides a baseline for understanding current and future landscape fire-vegetation interactions.ResultsHere, we present a detailed characterization of REBURN — a geospatial modeling framework designed to simulate reburn dynamics over large areas and long time frames. We interpret fire-vegetation dynamics for a large testbed landscape in eastern Washington State, USA. The landscape is comprised of common temperate forest and nonforest vegetation types distributed along broad topo-edaphic gradients. Each pixel in a vegetation type is represented by a pathway group (PWG), which assigns a specific state-transition model (STM) based on that pixel’s biophysical setting. STMs represent daily simulated and annually summarized vegetation and fuel succession, and wildfire effects on forest and nonforest succession. Wildfire dynamics are driven by annual ignitions, fire weather and topographic conditions, and annual vegetation and fuel successional states of burned and unburned pixels.ConclusionsOur simulation study is the first to evaluate how fire exclusion and forest management altered the active fire regime of this landscape, its surface and canopy fuel patterns, forest and nonforest structural conditions, and the dynamics of forest reburning. The REBURN framework is now being used in related studies to evaluate future climate change scenarios and compare the efficacy of fire and fuel management strategies that either enable the return of active fire regimes or depend on fire suppression and wildfire effects on forest burning.
Laboratory study of metakaolin and microsilica effect on the performance of high-strength concrete containing Forta fibers
Authors: Faghihmaleki Hadi , Nazari Hossien 
Published: June 2023

AbstractIn the present study aims to produce high-strength fiber concrete containing microsilica and metakaolin. Eight concrete mixing samples have been defined. The samples include the control concrete with ordinary Portland cement, replacing 10 percent of the weight of cement with microsilica. The amount of microsilica was kept constant in the next six designs. Three samples with the addition of Forta fibers at the rate of 0.2, 0.5, and 0.8 percent. Finally three samples with 0.5% Forta fibers and 8, 10 and 12% metakaolin were subjected to compressive, tensile and elastic modulus tests at the ages of 7 and 28 days. The addition of Forta fibers and the replacement of microsilica and metakaolin in concrete reduced the slump of concrete up to 5 cm. The highest compressive strength, tensile strength and elastic modulus at the age of 28 days of design 8 (concrete containing 10% microsilica, 0.5% Forte fibers and 12% metakaolin) are respectively equal to 73.6 MPa, 5.55 MPa and 37.49 MPa with The increase was 19.43%, 32.77% and 15.21% compared to control concrete without pozzolan and additives. Also, the relationship between compressive and tensile strength were presented. In total, all samples containing microsilica and fibers had a favorable effect on the resistance properties of concrete compared to the control design. The constant concern of bridge engineers, especially concrete bridges, is the production of concrete with high-strength and very low permeability in the face of their surroundings. Therefore, the result of this research can be a significant contribution to improving the quality of concrete used in bridge constructions.
Traits of Patients With Pituitary Tumors in Multiple Endocrine Neoplasia Type 1 and Comparing Different Mutation Status
Authors: Lin Kuan-Yu , Kuo Yu-Ting , Cheng Mei-Fang , Chen Pei-Lung , Wang Hsiu-Po , Cheng Tsu-Yao , Chang Chia-Hsuin , Kao Hsiang-Fong , Yang Shih-Hung , Li Hung-Yuan , Lin Chia-Hung , Chou Yuh-Tsyr , Chung An-Ko , Wu Wan-Chen , Lu Jin-Ying , Wang Chih-Yuan , Hsih Wen-Hui , Wen Chen-Yu , Yang Wei-Shiung , Shih Shyang-Rong 
Published: June 2023

Abstract

Context
Recent studies suggest that the clinical characteristics and biological behavior of pituitary tumors (PITs) in patients with multiple endocrine neoplasia type 1 (MEN1) may not be as aggressive as previously reported. Increased imaging of the pituitary as recommended by screening guidelines identifies more tumors, potentially at an earlier stage. However, it is unknown if these tumors have different clinical characteristics in different MEN1 mutations.

Objective
To assess characteristics of patients with MEN1 with and without PITs, and compare among different MEN1 mutations.

Methods
Data of patients with MEN1 in a tertiary referral center from 2010 to 2023 were retrospectively analyzed.

Results
Forty-two patients with MEN1 were included. Twenty-four patients had PITs, 3 of which were invasive and managed with transsphenoidal surgery. One PIT enlarged during follow-up. Patients with PITs had a higher median age at MEN1 diagnosis than those without PITs. MEN1 mutations were identified in 57.1% of patients, including 5 novel mutations. In patients with PITs, those with MEN1 mutations (mutation+/PIT+ group) had more additional MEN1-associated tumors than those without (mutation−/PIT+ group). The mutation+/PIT+ group had a higher incidence of adrenal tumors and a lower median age at initial manifestation of MEN1 than the mutation−/PIT+ group. The most common neuroendocrine neoplasm was nonfunctional in the mutation+/PIT+ group and insulin-secreting in the mutation−/PIT+ group.

Conclusion
This is the first study comparing characteristics of patients with MEN1 with and without PITs harboring different mutations. Patients without MEN1 mutations tended to have less organ involvement and it might be reasonable for them to receive less intensive follow-up.
Gestational Transient Thyrotoxicosis Complicated by Thyroid Storm in a Patient With Hyperemesis Gravidarum
Authors: Villavicencio Camila A , Franco-Akel Alberto , Belokovskaya Regina 
Published: June 2023

Abstract
We describe a patient with gestational transient thyrotoxicosis (GTT) associated with hyperemesis gravidarum (HG) in a twin gestation complicated by thyroid storm resulting in intrauterine fetal demise. GTT is a well-documented complication of the first trimester of pregnancy that may affect up to 60% of pregnancies with HG. Typically, GTT is not associated with unfavorable maternal or fetal outcomes and has a spontaneous resolution. Aside from supportive care, the use of antithyroid drugs (ATD) in GTT is not regularly recommended. Although to our knowledge one similar case has been reported in the literature, the incidence of thyroid storm in GTT has not yet been established. Our case highlights that, although rare, GTT may be complicated by thyroid storm resulting in adverse maternal and fetal outcomes. Our case further suggests that consideration of ATD use in GTT should be given in pregnancies with higher serum human chorionic gonadotropin (hCG) concentration as occurs in HG and multiple pregnancies.
Topological Data Analysis and Use of Mapper for Cerebral Aneurysm Rupture Status Discrimination Based on 3-Dimensional Shape Analysis
Authors: Lauric Alexandra , Ludwig Calvin G. , Malek Adel M. 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Topological data analysis (TDA), which identifies patterns in data through simplified topological signatures, has yet to be applied to aneurysm research. We investigate TDA Mapper graphs (Mapper) for aneurysm rupture discrimination.

METHODS:
Two hundred sixteen bifurcation aneurysms (90 ruptured) from 3-dimensional rotational angiography were segmented from vasculature and evaluated for 12 size/shape and 18 enhanced radiomics features. Using Mapper, uniformly dense aneurysm models were represented as graph structures and described by graph shape metrics. Mapper dissimilarity scores (MDS) were computed between pairs of aneurysms based on shape metrics. Lower MDS described similar shapes, whereas high MDS represented shapes that do not share common characteristics. Ruptured/unruptured average MDS scores (how “far” an aneurysm is shape-wise to ruptured/unruptured data sets, respectively) were evaluated for each aneurysm. Rupture status discrimination univariate and multivariate statistics were reported for all features.

RESULTS:
The average MDS for pairs of ruptured aneurysms were significantly larger compared with unruptured pairs (0.055 ± 0.027 vs 0.039 ± 0.015, P < .0001). Low MDS suggest that, in contrast to ruptured aneurysms, unruptured aneurysms have similar shape characteristics. An MDS threshold value of 0.0417 (area under the curve [AUC] = 0.73, 80% specificity, 60% sensitivity) was identified for rupture status classification. Under this predictive model, MDS scores <0.0417 would identify unruptured status. MDS statistical performance in discriminating rupture status was similar to that of nonsphericity and radiomics Flatness (AUC = 0.73), outperforming other features. Ruptured aneurysms were more elongated (P < .0001), flatter (P < .0001), and showed higher nonsphericity (P < .0001) compared with unruptured. Including MDS in multivariate analysis resulted in AUC = 0.82, outperforming multivariate analysis on size/shape (AUC = 0.76) and enhanced radiomics (AUC = 0.78) alone.

CONCLUSION:
A novel application of Mapper TDA was proposed for aneurysm evaluation, with promising results for rupture status classification. Multivariate analysis incorporating Mapper resulted in high accuracy, which is particularly important given that bifurcation aneurysms are challenging to classify morphologically. This proof-of-concept study warrants future investigation into optimizing Mapper functionality for aneurysm research.
Recurrent Chronic Subdural Hematoma After Burr-Hole Surgery and Postoperative Drainage: A Systematic Review and Meta-Analysis
Authors: Lodewijkx Roger , Foppen Merijn , Slot Kari-Anne Mariam , Vandertop William Peter , Verbaan Dagmar 
Published: June 2023

BACKGROUND AND OBJECTIVE:Reported recurrence rates of chronic subdural hematoma treated by burr-hole surgery with postoperative drainage vary considerably in the literature. We performed a systematic review and meta-analysis to define the recurrence rate of burr-hole surgery with postoperative drainage.METHODS:PubMed and EMBASE were searched, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. We used the Newcastle-Ottawa scale and Cochrane risk-of-bias tool for quality assessment of included studies and the random-effects model to calculate pooled incidence rates in R with the metaprop function if appropriate.RESULTS:The search yielded 2969 references; 709 were screened full text, and 189 met the inclusion criteria. In 174 studies (34 393 patients), the number of recurrences was reported as per patient and 15 studies (3078 hematomas) reported the number of recurrences per hematoma, for a pooled incidence of 11.2% (95% CI: 10.3-12.1; I2= 87.7%) and 11.0% (95% CI: 8.6-13.4; I2= 78.0%), respectively. The pooled incidence of 48 studies (15 298 patients) with the highest quality was 12.8% (95% CI 11.4-14.2; I2= 86.1%). Treatment-related mortality (56 patients) has a pooled incidence of 0.7% (95% CI 0.0-1.4; I2= 0.0%).CONCLUSION:The recurrence rate of chronic subdural hematoma treated by burr-hole surgery and postoperative drainage is 12.8%.
Expansion and Subsequent Rupture of Carotid Pseudoaneurysm After Tandem Carotid and Middle Cerebral Artery Occlusion Treated With Mechanical Thrombectomy and Carotid Stenting
Authors: Housley Steven B. , Turner Ryan C. , Bouslama Mehdi , Lim Jaims , Raygor Kunal P. , Lai Pui Man Rosalind , Monteiro Andre , Baig Ammad A. , Nyabuto Elizabeth , Davies Jason M. , Siddiqui Adnan H. , Snyder Kenneth V. , Levy Elad I. 
Published: June 2023

BACKGROUND AND IMPORTANCE:
Extracranial carotid artery pseudoaneurysm is a rare entity with potential etiologies including infection, blunt trauma, postsurgical atherosclerotic disease, and invasive neoplasia. Although the natural history of carotid pseudoaneurysm is difficult to determine because of its rarity, complications such as stroke, rupture, and local mass effect may occur at staggering rates.

CLINICAL PRESENTATION:
In this case, a middle-aged man presented with a tandem carotid, middle cerebral artery occlusion that was treated with a carotid stent and mechanical thrombectomy. He returned 3 weeks later with a ruptured carotid pseudoaneurysm that was then treated with a covered stent. He made a full recovery and was neurologically intact on follow-up.

CONCLUSION:
This case illustrates a rare potential complication of carotid occlusion and stenting with possible catastrophic consequences. The goal of this report was to educate other clinicians in remaining vigilant in awareness of this complication and provide a framework for potential treatment if and when it occurs.
Evaluation by app in smartphones of awake bruxism at the return of presential classes in two university centers
Authors: Velasquez Ron Byron , Mosquera Cisneros Veronica , Pazmiño Troncoso Pamela , Rodriguez Tates Maria , Alvares Lalvay Eddy , Chauca  Bajaña Luis , Ordoñez Balladares Andrea 
Published: June 2023

Background. The return to normality post-pandemic brought some inconveniences to the population, especially students. To evaluate the frequency of awake bruxism behaviors through the use of an app on smartphones in dental students returning to presential classes. Awake bruxism was evaluated with the creation of an app that according to the authors evaluates: relaxed jaw muscles, dental contact, jaw effort, clenching teeth and teeth grinding, 5 frequent oral conditions in the population. The frequency of awake/daytime bruxism (AB) in healthy individuals when comparing other populations with possible risk factors for additive bruxism (psychological factors, depression, suicide delusions, etc.), evaluating consequent clinical signs (fatigue, muscle pain, attritions and dental openings). Methods: The sample of three hundred (n=300) young adults legally enrolled in two Ecuadorian universities, the sample was selected among fifth, sixth, seventh, eighth and ninth semester students legally enrolled and who are attending Faculty of Dentistry classes in 2 different cities (Quito and Guayaquil). The app was configured to provide 20 alerts during the day x seven days a week, in real time. Results. The study obtained 95% reliability and 5% error in research, was used. The relaxation condition was present in all users, but 40% of the alerts were associated with jaw and tooth discomfort, 39% corresponded to the discomfort of mandibular clenching, and 24% corresponded to tooth contact. A direct significant association was found between the state of relaxation and nonrelaxation, with a high probability of reports related to nonrelaxation (p ≤ 0.05). Conclusions: Awake bruxism with the app was evaluated, identifying 5 behaviors such as: relaxed mandibular muscles, dental contact, mandibular effort, clenching and grinding teeth, frequent conditions in the population; reporting a state of mandibular relaxation, there is a high probability that a condition of nonrelaxation would be reported (p≤0.05).
Strategic Upward Striving Toward $100 Million Revenue: Setting Goals to Attract External Attention
Authors: Keum Daniel Dongil , Ryan Stephen 
Published: June 2023

We provide evidence that in certain contexts, firms set upward-striving goals and that this upward striving yields significant performance and visibility benefits. We develop a model of variable attention in which, as firms’ performance levels approach cognitively salient round numbers, managers strategically shift their focus from easier-to-reach goals based on historical and social reference points to more challenging goals that provide external visibility and capital market benefits. As one specific yet important instance of an upward shift in attention, we document a significant increase in revenue growth rates as firms’ annual revenue approaches $100 million. Firms achieving this goal obtain discontinuous increases in analyst and media coverage, investment by new institutional investors, and executive compensation. We find no evidence of decreased investment efficiency or profitability, suggesting that managers typically build slack into their goal levels. Our theory extends to goals based on other salient round numbers, such as revenue of $10 million, $500 million, and $1 billion. This study recasts behavioral theory of firm research in an open systems perspective, highlighting the externally directed aspects of firm goal setting. Supplemental Material: The online appendices are available at https://doi.org/10.1287/orsc.2021.15148 .