bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhabdomyosarcoma with isolated lung metastases: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
Authors: Vasquez Juan C. , Luo Leo Y. , Hiniker Susan M. , Rhee Daniel S. , Dasgupta Roshni , Chen Sonja , Weigel Brenda J. , Xue Wei , Venkatramani Rajkumar , Arndt Carola A. 
Published: March 2023

AbstractBackgroundTo determine outcomes of children with rhabdomyosarcoma (RMS) with isolated lung metastases.MethodsData were analyzed for 428 patients with metastatic RMS treated on COG protocols. Categorical variables were compared using Chi‐square or Fisher's exact tests. Event‐free survival (EFS) and overall survival (OS) were estimated using Kaplan–Meier method and compared using the log‐rank test.ResultsCompared with patients with other metastatic sites (n = 373), patients with lung‐only metastases (n = 55) were more likely to be <10 years of age, have embryonal histology (embryonal rhabdomyosarcoma), have N0 disease, and less likely to have primary extremity tumors. Lung‐only patients had significantly better survival outcomes than patients with all other sites of metastatic disease (p < .0001) with 5‐year EFS of 48.1 versus 18.8% and 5‐year OS of 64.1 versus 26.9%. Patients with lung‐only metastases, and those with a single extrapulmonary site of metastasis, had better survival compared with patients with two or more sites of metastatic disease (p < .0001). In patients with ERMS and lung‐only metastases, there was no significant difference in survival between patients ≥10 years and 1–9 years (5‐year EFS: 58.3 vs. 68.2%, 5‐year OS: 66.7 vs. 67.7%).ConclusionsWith aggressive treatment, patients with ERMS and lung‐only metastatic disease have superior EFS and OS compared with patients with other sites of metastatic disease, even when older than 10 years of age. Consideration should be given to including patients ≥10 years with ERMS and lung‐only metastases in the same group as those <10 years in future risk stratification algorithms.
Antenatal ultrasound features of isolated recurrent copy number variation in 7q11.23 (Williams syndrome and 7q11.23 duplication syndrome)
Authors: Courdier Cécile , Boudjarane John , Malan Valérie , Muti Christine , Sperelakis‐Beedham Brian , Odent Sylvie , Jaillard Sylvie , Quelin Chloé , Le Caignec Cédric , Patat Olivier , Dubucs Charlotte , Julia Sophie , Schluth‐Bolard Caroline , Goumy Carole , Redon Sylvia , Gaillard Jean‐Baptiste , Huynh Minh Tuan , Dupont Céline , Tabet Anne‐Claude , Cogan Guillaume , Vialard François , Dard Rodolphe , Jedraszak Guillaume , Jobic Florence , Lefebvre Mathilde , Quenum Geneviève , Inai Saori , Rama Mélanie , Sauvestre Fanny , Coatleven Frédéric , Thomas Julie , Rooryck Caroline 
Published: March 2023

AbstractObjectiveWe aimed to gather fetal cases carrying a 7q11.23 copy number variation (CNV) and collect precise clinical data to broaden knowledge of antenatal features in these syndromes.MethodsWe retrospectively recruited unrelated cases with 7q11.23 deletion, known as Williams‐Beuren syndrome (WBS), or 7q11.23 duplication who had prenatal ultrasound findings. We collected laboratory and clinical data, fetal ultrasound, cardiac ultrasound and fetal autopsy reports from 18 prenatal diagnostic centers throughout France.Results40 fetuses with WBS were collected and the most common features were intra‐uterine growth retardation (IUGR) (70.0%, 28/40), cardiovascular defects (30.0%, 12/40), polyhydramnios (17.5%, 7/40) and protruding tongue (15.0%, 6/40). Fetal autopsy reports were available for 11 cases and were compared with ultrasound prenatal features. Four cases of fetuses with 7q11.23 microduplication were collected and prenatal ultrasound signs were variable and often isolated.ConclusionThis work strengthens the fact that 7q11.23 CNVs are associated with a broad spectrum of antenatal presentations. IUGR and cardiovascular defects were the most frequent ultrasound signs. By reporting the biggest series of antenatal WBS, we aim to better delineate distinctive signs in fetuses with 7q11.23 CNVs.
A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4
Authors: Voss Martin , Cseke Leland J. , Gassmann Walter , Niefind Karsten 
Published: March 2023

AbstractEnhanced Disease Susceptibility 1 (EDS1), a key component of microbe‐triggered immunity and effector‐triggered immunity in most higher plants, forms functional heterodimeric complexes with its homologs Phytoalexin Deficient 4 (PAD4) or Senescence‐associated Gene 101 (SAG101). Here, the crystal structure of VvEDS1Nterm, the N‐terminal domain of EDS1 from Vitis vinifera, is reported, representing the first structure of an EDS1 entity beyond the model plant Arabidopsis thaliana. VvEDS1Nterm has an α/β‐hydrolase fold, is similar to the N‐terminal domain of A. thaliana EDS1 and forms stable homodimers in solution as well as in crystals. These VvEDS1Nterm homodimers are spatially incompatible with heterodimers with PAD4 or SAG101, they explain why VvEDS1Nterm does not interact with V. vinifera PAD4 according to gel filtration, and they serve as a guide to develop a plausible, albeit experimentally not verified model of full‐length EDS1. VvEDS1Nterm is a splicing variant comprising two of three exons of the VvEDS1 gene. It originates from a naturally occurring mRNA, in which the first of two introns was removed while the second one containing a stop codon close to the exon/intron border was retained. This is a potential case of intron retention and the first report of this phenomenon in the context of EDS1. Its biological significance has not yet been clarified, nor has the question if a VvEDS1Nterm protein with a specific function can occur under physiological conditions.
A CNN‐BiLSTM‐Bootstrap integrated method for remaining useful life prediction of rolling bearings
Authors: Guo Junyu , Wang Jiang , Wang Zhiyuan , Gong Yu , Qi Jinglang , Wang Guoyang , Tang Changping 
Published: March 2023

AbstractRolling bearings, an essential fundamental component in machinery and equipment, have been widely used. Predicting the remaining useful life (RUL) of rolling bearings helps maintain the reliability of mechanical systems. Accurate prediction of RUL requires extracting deep features in complex non‐linear vibration signals, the prediction results often vary widely. This paper proposes a RUL prediction method based on convolutional neural network (CNN), bi‐directional long‐short term memory (BiLSTM), and bootstrap method (CNN‐BiLSTM‐Bootstrap) to model the forecasting uncertainty. The first step is to extract the first prediction time (FPT) of the degradation phase of rolling bearings using an adaptive method for the 3σ intervals of rolling bearing vibration signal kurtosis. The model extracts the spatio‐temporal features through CNN and BiLSTM, and combines the bootstrap method to quantify the RUL prediction interval (PI) of rolling bearings. The comparison with existing models verified the effectiveness and generalization of the proposed model.
Towards the development of a systematic approach for sustainability assessment of educational infrastructure: A system of priority areas and design quality indicators
Authors: Primc Kaja , Slabe‐Erker Renata , Dominko Miha 
Published: March 2023

AbstractDesign quality indicators have yet to be widely applied for assessing the sustainability of educational infrastructure. In this sector, the indicators have centred around seismic resilience and energy performance in case‐oriented studies dependent on primary data collection. However, access to good quality data about the building stock in European Union member states is required to support the planning of beneficial public educational infrastructure. The aim of this paper is to establish the process of developing a set of key design quality indicators for educational infrastructure in line with European legislation and the Sustainable Development Goals 2030. In total, 31 design quality indicators are proposed to cover the following priority areas: building stock and safety, user experience, energy efficiency, digital infrastructure and equipment, and environment (emissions and natural resources). These proposed priority areas and analysis of the available data reveal a situation in which national and international decision‐making authorities are constrained by the lack of data and their accuracy, obsolescence and vagueness. Currently, one cannot make an unbiased decision on the investments required for educational infrastructure. This means the greatest value of this work lies in potential application of the comprehensive system of priority areas and design quality indicators for international performance comparisons and evidence‐based policy decision‐making processes related to educational infrastructure, for example, investments, engineering and social matters.
Analysing the alignment between circular economy and industry 4.0 nexus with industry 5.0 era: An integrative systematic literature review
Authors: Atif Sehrish 
Published: March 2023

AbstractCircular economy (CE) and Industry 4.0 (I4.0) laid the foundation of intelligent and sustainable manufacturing based on real‐time data collection. However, the absence of a human‐centric approach has recently pushed for a more value‐driven Industry 5.0 (I5.0) vision. A systematic literature review is conducted by critically analysing the peer‐reviewed academic journals to evaluate the material‐flow of a product's lifecycle and information‐flow in a data‐driven platform to find any existing relationship between the CE and I4.0 nexus with I5.0. The results indicate that the application of I5.0 is significantly more comprehensive as it is not limited to industry‐focused but also considers broader societal values. I5.0 places the human‐centric approach at the centre of the production process and utilise innovative technical advancement to provide a sustainable and resilient smart manufacturing path. It extends the tech features of I4.0 and complements the CE paradigm that prospers beyond jobs and growth while respecting the environment.
Synthesis of Different Nano‐layer Shells (Mono‐, Bi‐, and Alloy Layers)‐Coated Gold Spherical Nanoparticles Core for Catalysis
Authors: Sundarapandi Manickam , Shanmugam Sivakumar , Ramaraj Ramasamy 
Published: March 2023

AbstractVarious types of metal layer shells such as mono‐, bi‐, and alloy layer using gold and silver on preformed gold spherical nanoparticles core were synthesizing using sodium borohydride as reducing agent. UV‐vis absorption spectroscopy, transmission electron microscopy images, and X‐ray diffraction techniques were used to characterize the prepared pristine gold spherical nanoparticles and various core‐shell metal nanoparticles. High‐angle annular dark field scanning transmission electron microscopy‐energy dispersive X‐ray spectroscopy mapping images were recorded for the alloy and bilayer shell coated core‐shell nanoparticles. Catalytic reduction of 4‐nitroaniline in the presence of sodium borohydride was taken to study the catalytic activity of the prepared core‐shell nanostructures. Interestingly, the alloy shell coated gold spherical nanoparticles (AuNP@AgAu) showed the best catalytic activity (higher rate constant; 21.61×10−3 s−1) than that of mono‐, and bilayer core‐shell and pristine gold spherical nanoparticles.
Review of electrochemical transition‐metal‐catalyzed C−H functionalization reactions
Authors: Changmai Sumi , Sultana Sabera , Saikia Anil K. 
Published: March 2023

AbstractThe combination of organometallic C−H activation and electro‐catalysis has emerged as a potent synthetic technique for various molecular scaffolds since it avoids the use of harmful and expensive chemical oxidants in stoichiometric amounts. Moreover, the pre‐functionalization of substrates is not required and newer ways to perform metal‐catalyzed C−H activation reactions are possible. Here, we have discussed eletrochemically driven C−H acyloxylation, acetoxylation, oxygenation, acylation, amination, alkylation, halogenation, olefinations and C−H/N−H annulation reactions using various transition‐metal‐catalyst such as Ru, Rh, Pd, Co, Ni, Ir, Cu, Mn and Au by anodic oxidation, followed by reductive elimination to form the corresponding C−O, C−C, C−N and C−X (X=Cl, Br, S etc.) bonds. This review covers recent developments in transition‐metal‐catalyzed electrochemical C−H activation from 2007 until 2022.
Non‐Isothermal Kinetics of Phoenix Dactylifera L. Date Palm Seeds Pyrolysis Using Model Fitting and Iso‐Conversional Model Free Methods
Authors: Marouani Maryam El , El Hamdaoui Lahcen , Boulhaoua Mohammed , Pienaar Andrew , Trif László , Costa Guy , Simo‐Tagne Merlin , Kifani‐Sahban Fatima 
Published: March 2023

AbstractIn this paper, Phoenix dactylifera L. date palm seeds (RDS) were first characterized from a physicochemical point of view, in particular the proximate and ultimate composition, XRD, and SEM–EDX analyses. Based on findings RDS contains 77.4 % of total carbohydrates, 12.8 % of lignin, and a higher heating value (HHV) of 15.88 MJ kg−1. Immuno‐labeling intensity (OD) of non‐cellulosic RDS fraction was also determined thanks to the ELISA technique after the dissolution of polysaccharides in ionic liquid showing the presence of mannans and xyloglucans and the absence of arabinans in date seeds, a significant amount of homogalacturonans were also detected. The thermal decomposition and kinetic of date palm seeds (RDS) using TGA‐DTG, and DSC measurements were then investigated. The RDS samples were heated in the temperature ranges 25–600 °C at 5, 10, 15, and 20 °C/min. The decomposition of hemicelluloses, cellulose, and lignin, active pyrolysis of RDS, was held in a range of temperature 160–450 °C. The kinetic parameters such as activation energy (Ea) and pre‐exponential factor (A) were determined for two degradation steps by using iso‐conversional model‐free methods. The Ea and pre‐exponential factor obtained by the Kissinger method are 212 kJ mol−1 and 7.8×1019 min−1 for the first decomposition interval (I1) and 172 kJ mol−1 and 5.96×1013 min−1 for the second decomposition interval I2. The same average parameters calculated by model‐free methods are 126–156 kJ mol−1 and 180–213 kJ mol−1 and 3.36×1014 and 7.07×1017 min−1 respectively for the first and second intervals of thermal decomposition. Indicating that activation energy decreases in the final stages of the process and that the energy required for hemicelluloses degradation is lower than that of cellulose. The most probable reaction functions have been determined for these two stages, by Coats‐Redfern (CR) and Criado methods, leading to considerably improved calculation performance over the entire conversion range. The pyrolysis reaction models of RDS are described by reaction, second order F2 for cellulose and hemicelluloses. With the Arrhenius parameters obtained from the fitting model of CR, we attempt to reconstruct the temperature‐dependent mass conversion curves and have resulted in generally acceptable results. Based on the Arrhenius parameter values, obtained by the Kissinger equation, the changes in entropy, enthalpy, Gibbs free energy, and lifetime predictions have been estimated for the thermal degradation processes of RDS.
Calix[4]pyrrole‐Grafted Gold Nanoparticles as a Turn‐On Fluorescence Sensor for Noxious Fungicide Dimoxystrobin and Their Anti‐Cancer Activity against the KB‐3‐1 Cell Line
Authors: Pomal Nandan C. , Bhatt Keyur D. , Kundariya Dinesh S. , Desai Riya A. , Bhatt Vaibhav , Kongor Anita 
Published: March 2023

AbstractA rapid and easy approach for producing very stable gold nanoparticles has been discovered. Calix[4]pyrrole tetrahydrazide (CPTAH) was utilized effectively in the synthesis of gold nanoparticles as a reducing and stabilizing agent. These functionalized AuNPs were characterized by Surface Plasmon Resonance, Transmission Electron Microscopy, Selected Area Electron Diffraction, and Energy Dispersive X‐ray techniques. CPTAH‐AuNPs possessed a particle size of 11±2 nm and are highly stable at pH 7.0 for more than 150 days. The selectivity and sensitivity of CPTAH‐AuNPs as a fungicide sensor was assessed for Metalaxyl, Mancozeb, Tebuconazole, Tricyclozole, Dimoxystrobin, Kresoxim‐methyl, and Carbendazim, amongst which Dimoxystrobin (DMX) was sensed exclusively with naked eyes by means of aggregation of CPTAH‐AuNPs with a detection limit of the order of 5 ppm using “Turn‐on” fluorescence enhancement. Additionally, the CPTAH‐AuNPs were found to be effective cytotoxic agent against the human cervix cancer cell line KB‐3‐1 with IC50 value of 64.63 μg/mL which admits the employability of CPTAH‐AuNPs in the study of development of anti‐cancer drug.
Flexible Multimodal Sensor Based on Double‐network Hydrogel for Human and Robotic Applications
Authors: Zou Qiang , Zhang Shiwen , Su Qi , Xue Tao , Lan Kuibo 
Published: March 2023

AbstractWith the development of wearable technology, there are higher requirements for wearable sensors, such as multimodal sensing, superior mechanical properties, and simple and easy‐to‐fabricate structures. However, it is difficult for existing flexible sensors to possess all these advantages simultaneously. Herein, a flexible multimodal sensor based on sodium alginate/polyvinyl alcohol/graphene oxide double‐network hydrogel was prepared. The multiple hydrogen bonds between the two networks provided the gel with great mechanical properties. In addition, the flexibility and easy‐to‐fabricate simple structure of hydrogels were ideal for wearable sensors. In particular, the hydrogel sensors have a temperature sensitivity of up to 2.81 %/°C between −20 °C and 55 °C and pressure sensitivity of 0.03 kPa−1, both of which have excellent properties of stability and repeatability. Besides, the sensor also presented a humidity sensitivity of 0.027 % RH−1. This work also applied hydrogel sensors to practical applications and provided a new idea for wearable technology.
Synthesis of Functionalized 2′,5‐Oxo‐spiro[furan‐2,3′‐indoline]‐3‐carboxylate Derivatives as Antiproliferative Agents: ADMET Studies, and Molecular Docking against P2Y12 Inhibitors
Authors: Asif Mohd , Saquib Mohammad , Rahman Khan Abdul , Aqil Farrukh , salem Almalki Amani , Ali Alasmary Fatmah , Singh Jaya , Nasibullah Malik 
Published: March 2023

AbstractHerein, we present a one‐pot, three‐component synthesis of spirooxindole‐oxofuran carboxylate derivatives (4 a–d) through the Huisgen reaction. The newly synthesized spirocyclic compounds were tested for in vitroantiproliferative efficacy against 60 human cancer cell lines at the National Cancer Institute (NCI) in the United States. The screening results indicated that two spirooxindole compounds, 4 b and4 c, possessed the strongest anti‐cancer efficacy in terms of percentage growth inhibition (% GI), with values of 34.17 and 38.19 at 10−5 M concentration against the CNS cancer panel‘s SNB‐75 cell line, respectively. Furthermore, molecular docking investigations demonstrated the binding affinity for the P2Y12 receptor. The compound 4 c which exhibited strong antiproliferative activity with high binding energies might therefore, serve as a potential lead molecule for the development of more effective anti‐cancer agents.
A Novel Pyridine and Julolidine Based Chemosensor for Al3+ Detection
Authors: Zeng Junzhu , Xu Xin , Xue Lei , Xu Yang , Wang Xin , Zhang Yang , Wang Haibin 
Published: March 2023

AbstractIn this work, a pyridine and julolidine based chemosensor (L) for Al3+ with a turn‐on response in ethanol solution was designed and synthesized, whose emission intensity was enhanced by 85‐fold in the presence of Al3+ by emitting bright green fluorescence at 480 nm. Meanwhile, the recognition process was hardly affected by other common cations. Based on the fluorescence titration data, the limit of detection (LOD) for Al3+ was estimated to be as low as 2.74×10−8 M. Job's plot ascertained the coordinate stoichiometric of L to Al3+ as 1 : 1, with the association constant (Ka) of 7.24×103 M−1 depending on the Benesi‐Hildebrand equation. The combined effects of photoinduced electron transfer (PET) and excited state intramolecular proton transfer (ESIPT) were proposed as the plausible coordination mechanism of L toward Al3+. Moreover, the application ability of L for determination of Al3+ was evaluated in water samples and with test strips.
An Expeditious One‐Pot Two‐Component Synthesis of Quinoxaline Derivatives in Natural Deep Eutectic Solvents (NADESs)
Authors: Das Arindam , Dey Sovan , Naresh Yadav Ram , Jyoti Boruah Palash , Bakli Prerana , Sarkar Sourav , Mahata Partha , Kumar Paul Amit , Hossain Md. Firoj 
Published: March 2023

AbstractA facile and eco‐friendly sustainable synthesis of functionalized quinoxaline derivatives from 1,2‐diaminobenzenes and 2‐bromoacetophenones via a one‐pot two‐component reaction using choline chloride (ChCl): glycerol as a bio‐renewable DES has been developed. In this protocol, nucleophilic 1,2‐diaminobenzenes are mixed with phenacyl bromides or 3‐(bromoacetyl) coumarin to produce quinoxaline derivatives in a high yield (up to 96 %), with a clean reaction profile without the use of a solvent or catalyst at ambient temperature (80 °C). The presence of DES is proven to be essential for assuring efficient transformation, as the product yield was extremely low with a slow reaction profile in the absence of this media. The DES media could be recycled and reused up to five times without losing its efficiency or affecting the chemical yield of the reaction. In the showcase study, the reaction was also scaled up to the gram scale (10 mmol scale), revealing the synthetic potential of the current approach. A DFT calculation has been also performed to probe the mechanism and reversal of the regioselectivity in the products formation.
Glycosyl Isoxazoles for Targeting of Tumor Microenvironment and Cancer Cells: Highly Selective Inhibitors of Carbonic Anhydrases IX and XII Showing Cytotoxic Activity
Authors: Le Pors Macarena S. , Santa Maria de la Parra Lucía , Riafrecha Leonardo E. , Vullo Daniela , León Ignacio E. , Supuran Claudiu T. , Colinas Pedro A. 
Published: March 2023

AbstractWe report the synthesis of twelve novel O‐glycosylmethyl isoxazoles incorporating the phenoxyaryl moiety, that were designed to selectively target the cancer‐related human carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The O‐glycosides have been prepared by cycloaddition of nitrile oxides to O‐propargyl glycosides. Compounds were assessed as inhibitors of the physiologically dominant isozymes hCA I and II and the tumor‐associated isozyme hCA IX and hCA XII. In this study, several glycosides have been identified as highly selective inhibitors of hCA IX and XII. Glycoconjugation enhances the anticancer activity against human osteosarcoma cell line. Thus, these glycosides may prove interesting lead candidates for a targeted cancer therapy.