bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catastrophic health expenditure, incidence, trend and socioeconomic risk factors in China: A systematic review and meta-analysis
Authors: Zhang Fangkai , Jiang Jianjun , Yang Min , Zou Kun , Chen Dandi 
Published: January 2023

ObjectiveTo evaluate the incidence and trend of catastrophic health expenditures (CHE) in China over the past 20 years and explore the socioeconomic factors affecting China's CHE rate.MethodsThe systematic review was conducted according to the Cochrane Handbook and reported according to PRISMA. We searched English and Chinese literature databases, including PubMed, EMbase, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang, China Science and Technology Journal Database (CQVIP), and CBM (Sino Med), for empirical studies on the CHE rate in China and its associated socioeconomic factors from January 2000 to June 2020. Two reviewers conducted the study selection, data extraction, and quality appraisal. The secular trend of the CHE rate was examined, and factors associated with CHE were explored using subgroup analysis and meta-regression.ResultsA total of 118 eligible studies with 1,771,726 participants were included. From 2000 to 2020, the overall CHE rate was 25.2% (95% CI: 23.4%−26.9%) in China. The CHE rate continued to rise from 13.0% in 2000 to 32.2% in 2020 in the general population. The CHE rate was higher in urban areas than in rural areas, higher in the western than the northeast, eastern, and central region, in the elderly than non-elderly, in low-income groups than non-low-income groups, in people with cancer, chronic infectious disease, and cardio-cerebrovascular diseases (CCVD) than those with non-chronic disease group, and in people with NCMS than those with URBMI and UEBMI. Multiple meta-regression analyses found that low-income, cancer, CCVD, unspecified medical insurance type, definition 1 and definition 2 were correlated with the CHE rate, while other factors were all non-significantly correlated.ConclusionIn the past two decades, the CHE rate in China has been rising. The continuous rise of health expenditures may be an important reason for the increasing CHE rate. Age, income level, and health status affect the CHE rate. Therefore, it is necessary to find ways to meet the medical needs of residents and, at the same time, control the unreasonable rapid increase in health expenditures in China.
Extraction of high-quality grade cellulose and cellulose nanocrystals from different lignocellulosic agri-food wastes
Authors: Rovera Cesare , Carullo Daniele , Bellesia Tommaso , Büyüktaş Duygu , Ghaani Masoud , Caneva Enrico , Farris Stefano 
Published: January 2023

IntroductionPrompted by the increasing need for an intensified valorization of agri-food waste, in this work a three-step chemical procedure was used to extract high-purity cellulose from garlic stalk, corncob, and giant cane cut-up by a sequential removal of hemicellulose, lignin, ash, and organic compounds. Cellulose nanocrystals of potential interest for nanocomposite applications were then obtained through acid hydrolysis.MethodsThe purity of the cellulose was determined employing Nuclear Magnetic Resonance and infrared spectroscopy, whereas dynamic light scattering, optical, atomic force microscopy, and transmission electron microscopy were used for morphological characterization. The high purity and crystallinity of cellulose was confirmed by comparison with the ultra-pure bacterial cellulose originating from K. sucrofermentans, irrespective of the waste used.Results and discussionAt the end of the extraction procedure, cellulose yields of 35.73, 37.15, and 39.10%, for garlic stalk, corncob, and giant cane cut-up, respectively, were achieved. Dynamic light scattering and atomic force microscopy analyses showed that the length of the whisker-like nanocrystals depended on the raw material (from ~100 nm up to &gt; 2μm), while the final yield was ~40–50% for all three wastes. The versatility and effectiveness of the method here proposed can be profitably used for a wide range of agro-waste feedstocks.
Signatures and prognostic values of related immune targets in tongue cancer
Authors: Lv Xiaofei , Yu Xi 
Published: January 2023

BackgroundTongue cancer, as one of the most malignant oral cancers, is highly invasive and has a high risk of recurrence. At present, tongue cancer is not obvious and easy to miss the opportunity for early diagnosis when in the advanced stage. It is important to find markers that can predict the occurrence and progression of tongue cancer.MethodsBioinformatics analysis plays an important role in the acquisition of marker genes. GEO and TCGA data are very important public databases. In addition to expression data, the TCGA database also contains corresponding clinical data. In this study, we screened three GEO data sets that met the standard, which included GSE13601, GSE34105, and GSE34106. These data sets were combined using the SVA package to prepare the data for differential expression analysis, and then the limma package was used to set the standard to p &lt; 0.05 and |log2 (FC)| ≥ 1.5.ResultsA total of 170 differentially expressed genes (DEGs) were identified. In addition, the DEseq package was used for differential expression analysis using the same criteria for samples in the TCGA database. It ended up with 1,589 DEGs (644 upregulated, 945 downregulated). By merging these two sets of DEGs, 5 common upregulated DEGs (CCL20, SCG5, SPP1, KRT75, and FOLR3) and 15 common downregulated DEGs were obtained.ConclusionsFurther functional analysis of the DEGs showed that CCL20, SCG5, and SPP1 are closely related to prognosis and may be a therapeutic target of TSCC.
Joys or Sorrows of Parenting During the COVID-19 Lockdown: A Scoping Review
Authors: Fadda Marta , Melotto Matilde , Caiata-Zufferey Maria , Puhan Milo Alan , Frei Anja , Albanese Emiliano , Camerini Anne-Linda 
Published: January 2023

Objectives: The aim of this scoping review was to map out the existing evidence of the impact of the COVID-19 lockdown on parents of children and adolescents. We sought to: 1) identify parenting domains that were particularly affected by lockdown measures, 2) describe the challenges and opportunities of lockdown measures in these domains, and 3) define protective and exacerbating factors modulating the effect of lockdown measures on parents.Methods: We identified five main domains investigated in the context of parenting during the early COVID-19 lockdown derived from 84 studies: health and wellbeing, parental role, couple functioning, family and social relationships, and paid and unpaid work. For each domain, we listed challenges and opportunities, as well as discriminant factors.Results: The lockdown impacted all five different but interconnected domains, introduced new roles in parents’ lives, and particularly affected women and vulnerable populations.Conclusion: This scoping review highlights the importance of approaching public health policymaking from a social justice perspective. Such an approach argues for social and public health policies to promote health accounting for its social, economic, political, and commercial determinants.
Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation
Authors: Liao Xiaoli , Chen Junming , Luo DongCheng , Luo Baohua , Huang Wenfeng , Xie Weimin 
Published: January 2023

Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p &lt; 0.05). High MALAT1 expression was associated with mutations in two genes leading to poor prognosis and may upregulate some prognostic risk genes through methylation. MALAT1 was significantly co-expressed with various signatures of genes involved in HCC progression, including the cell cycle, DNA damage repair, mismatch repair, homologous recombination, molecular cancer m6A, exosome, ferroptosis, infiltration of lymphocyte (p &lt; 0.05). The expression of MALAT1 was markedly upregulated in HCC tissues compared with PANTs. In Kaplan-Meier analysis, patients with high MALAT1 expression had significantly shorter progression-free survival (PFS) (p = 0.033) and overall survival (OS) (p = 0.023) than those with low MALAT1 expression. Median PFS was 19.2 months for patients with high MALAT1 expression and 52.8 months for patients with low expression, while the corresponding median OS was 40.5 and 78.3 months. In subgroup analysis of patients with vascular invasion, cirrhosis, and HBsAg positive or AFP positive, MALAT1 overexpression was significantly associated with shorter PFS and OS. Models for predicting PFS and OS constructed based on MALAT1 expression and clinicopathological features had moderate predictive power, with areas under the receiver operating characteristic curves of 0.661–0.731. Additionally, MALAT1 expression level was significantly associated with liver cirrhosis, vascular invasion, and tumor capsular infiltration (p &lt; 0.05 for all).Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.
Lactic Bacteria in Artisanal Cheese: Characterization through Metagenomics
Authors: Erhardt Magnolia Martins , Oliveira Wemerson de Castro , Fröder Hans , Marques Pedro Henrique , Oliveira Maria Beatriz Prior Pinto , Richards Neila Silvia Pereira dos Santos 
Published: January 2023

Artisanal cheese, produced with raw milk by a predominantly manual approach, has a historical and cultural tradition related to the region of origin. Given its economic and cultural importance, the main objective of this study was to investigate and characterize the diversity of lactic acid bacteria (LAB) of artisanal cheeses produced and traded by family agro-industries in a region of southern Brazil. The LAB composition of artisanal cheese samples, belonging to different municipalities of the Region of Vale do Taquari, were characterized by the next-generation sequencing (NGS) method, amplifying the V3/V4 region of the 16S rRNA gene. A total of 35 LAB species, distributed in seven genera, were identified, and rarefaction analysis suggested that the total diversity assessed by 16S rRNA analysis was high in the analyzed samples. The average Ph ranged from 4.6 to 6.6, and a correlation with the genus Lactococcus (r = 0.62) was the most expressive. The LAB genera identified in the cheese samples were Bavariicococcus, Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Marinillactibacillus, and Pediococcus. Lactococcus lactis was the most predominant species, present in all samples. Although some species have been identified in the three altitudes studied, the abundance varied according to geographic environments. Enterococcus italicus is more present at high altitudes, unlike Lactococcus plantarum and Lactococcus raffinolactis at low altitudes. Lactococcus lactis was present in the three geographic environments evaluated, but the highest abundance was observed at high altitudes. The identification of LAB present in fermented cheeses is essential to understand the organoleptic quality during the maturation process as well as to establish the shelf life, including the safety and the overall quality of the cheese. This specific microbiota contributes to the flavor and unique characteristics of the regional dairy products, and on the other hand can be a source of specific starter cultures that guarantee the product’s identity.
Topological Structure of Solution Sets of Fractional Control Delay Problem
Authors: Ghafli Ahmed A. Al , Shafqat Ramsha , Niazi Azmat Ullah Khan , Abuasbeh Kinda , Awadalla Muath 
Published: January 2023

This paper is concerned with the existence of a mild solution for the fractional delay control system. Firstly, we will study the control problem. Then, we will deal with the topological structure of the solution set consisting of the compactness and Rσ property. We will derive a mild solution to the above delay control problem by using the Laplace transform method.
Genome-Wide Identification and Characterization of the Trehalose-6-Phosphate Synthetase Gene Family in Chinese Cabbage (Brassica rapa) and Plasmodiophora brassicae during Their Interaction
Authors: Kong Liyan , Liu Jiaxiu , Zhang Wenjun , Li Xiaonan , Zhang Yuting , Chen Xueyu , Zhan Zongxiang , Piao Zhongyun 
Published: January 2023

Trehalose is a nonreducing disaccharide that is widely distributed in various organisms. Trehalose-6-phosphate synthase (TPS) is a critical enzyme responsible for the biosynthesis of trehalose, which serves important functions in growth and development, defense, and stress resistance. Although previous studies have found that the clubroot pathogen Plasmodiophora brassicae can lead to the accumulation of trehalose in infected Arabidopsis organs, it has been proposed that much of the accumulated trehalose is derived from the pathogen. At present, there is very little evidence to verify this view. In this study, a comprehensive analysis of the TPS gene family was conducted in Brassica rapa and Plasmodiophora brassicae. A total of 14 Brassica rapa TPS genes (BrTPSs) and 3 P. brassicae TPS genes (PbTPSs) were identified, and the evolutionary characteristics, functional classification, and expression patterns were analyzed. Fourteen BrTPS genes were classified into two distinct classes according to phylogeny and gene structure. Three PbTPSs showed no significant differences in gene structure and protein conserved motifs. However, evolutionary analysis showed that the PbTPS2 gene failed to cluster with PbTPS1 and PbTPS3. Furthermore, cis-acting elements related to growth and development, defense and stress responsiveness, and hormone responsiveness were predicted in the promoter region of the BrTPS genes. Expression analysis of most BrTPS genes at five stages after P. brassicae interaction found no significant induction. Instead, the expression of the PbTPS genes of P. brassicae was upregulated, which was consistent with the period of trehalose accumulation. This study deepens our understanding of the function and evolution of BrTPSs and PbTPSs. Simultaneously, clarifying the biosynthesis of trehalose in the interaction between Brassica rapa and P. brassicae is also of great significance.
How Can We Stabilize Soil Using Microbial Communities and Mitigate Desertification?
Authors: Dhawi Faten 
Published: January 2023

The desert, which covers around one-third of Earth’s continental surface, is defined as the harshest terrestrial environment and comprises a highly extensive biome of the terrestrial ecosystem. Microorganisms are key drivers that maintain the integrity of desert terrestrial ecosystems. Over the past few decades, desertification has increased owing to changes in rainfall patterns and global warming, characterized by land degradation, loss of microbial diversity (biocrust diversity), and multifunctionality with time. Soil stabilization is a geotechnical modality that improves the physiochemical properties of the soil. Biological modality is an emerging method that attracts the scientific community for soil stabilization. Enriching the soil with microorganisms such as some bacteria geniuses (Cystobacter, Archangium, Polyangium, Myxococcus, Stigmatella and Sorangium, Bacillus, Acinetobacter, Proteus, Micrococcus, and Pseudom) or Cyanobacteria (Oscillatoria pseudogeminata, Chroococcus minutus, Phormidium Tenue, and Nostoc species), and Lichens (Collema sps., Stellarangia sps., and Buellia species) might contribute to stabilizing the soil and mitigating desertification. In this timeline review article, we summarize the biological method of soil stabilization, especially focusing on the role of microorganisms in soil stabilization in the desert.
Screening Wild Pepper Germplasm for Resistance to Xanthomonas hortorum pv. gardneri
Authors: Tóth Zoltán Gábor , Tóth Máté , Fekete Sándor , Szabó Zoltán , Tóth Zoltán 
Published: January 2023

Bacterial spot disease on peppers is caused by four species of the genus Xanthomonas. This disease causes black spot lesions not only on the leaves but also on the fruit, leading to yield and quality loss. Xanthomonas species cause major disease outbreaks in tropical, subtropical and humid continental regions worldwide. Bacterial blight caused by xanthomonads occurs on both greenhouse- and field-grown peppers and is particularly important in areas characterized by hot and humid environmental conditions. As pesticides are currently not sufficiently effective in the control of bacterial spot, the development of pepper varieties resistant to Xanthomonas species, including X. hortorum pv. gardneri, is of primary importance for sustainable production. In our research, 119 lines of Capsicum baccatum from the USDA ARS gene bank (Griffin, GA) and MATE (Hungarian University of Agriculture and Life Sciences) were tested against strains of X. hortorum pv. gardneri under greenhouse conditions. Four accessions of the wild pepper species C. baccatum appeared to be resistant to seven strains of X. hortorum pv. gardneri in greenhouse trials. The resistant genotypes of X. hortorum pv. gardneri identified in this study can be used for the resistance gene pyramidation against different bacterial spotted Xanthomonas species in pepper.
L’évolution du genre « histoire alternative » dans les littératures russes contemporaines de l’imaginaire
Authors: Goularian Artem 
Published: January 2023

The Evolution of Alternative History in Russian Science Fiction.
The production of alternative history has long been a feature of russian science fiction, echoing social debate on the country’s past and the appropriateness of its present-day political structure. The subjects range from the time of troubles to Gorbachev’s perestroika. of greatest interest are the Civil War and World War II. Attempts to revise the past represent attempts to right presumed historical injustice.
Les traditions classiques et les anti-utopies russes contemporaines
Authors: Lanine Boris 
Published: January 2023

The classical tradition and the modern Russian dystopian novel.
This article argues that modern Russian dystopian fiction draws upon such wellknown classical texts as ‘ We’ by Evgeny Zamyatin and ‘ 1984’ by George Orwell. In the analysis of modern russian anti-utopian novels by Vladimir Sorokin, Victor Pelevin, Mikhail Yur´ev features of the genre emerge as follows : 1) the impact of a failed utopian project ; 2) a catastrophic event triggers the rise of a new historical order or at least a new order of priorities in envisaging the chronology of events in the past ; 3) an ‘ anti-utopian virus’ is spread by a charismatic protagonist 4) ‘ utopian’ mythology of body 5) the presence of a border between the utopian world and ‘ another’ world ; 6) Big Brother or Benefactor whose presence is felt everywhere ; 7) symbolic representation of devices for maintaining hegemonic control : the ‘ Integral,’ ‘ Mystery Weapon,’ or ‘ Global Shield’ (as in Mikhail Yur´ev’s novel ‘The Third empire’) ; 8) parody and social satire.
La composante ukrainienne des littératures de l’imaginaire dans l’espace postsoviétique
Authors: Logvinenko Natalia 
Published: January 2023

Ukrainian Fantastic Fiction in Russian.
The article considers the underpinnings of this genre in mythological, utopian and dystopian writing, historical, humorous and satirical science fiction, alternative history, crypto-story, philosophical thriller, the literary fairy tale, speculative fiction, turbo-realism and horror fiction. Considering the most prominent themes – mysticism and fantasy – the authors surveys the works of Marina and Sergey Dyachenko, Dmitryi Gromov and Oleg Ladyzhenskyi, Andrey Valentinov.
La gourmandise poétique ou les banquets philosophiques de Gavriil Derjavine
Authors: Vatcheva Anguélina 
Published: January 2023

The Poetical Glutton : Derzhavin’s Philosophical Banquets.
this paper focuses on the poetic still lives of the great russian poet of the late 18th – early 19th century Gavrila derzhavin. derzhavin was among the first people in russia to show interest to this specific genre, long before it became popular in russian art. the poet’s famous depictions of food and friendly banquets conveyed a specific philosophical message. they expressed derzhavin’s reflections on the meaning of life and the inevitability of death, on the search of pleasure and the price of friendship. While they often appeared as parts of wider poems, especially in derzhavin’s grand “ apologetic” odes, these still lives also appeared as independant texts. they were highly picturesque, particularly when describing russian national food. Famous for their sophisticated use of color, derzhavin’s still lives also served as a laboratory for the poet’s experiments with poetic langage.
Portrait du Voyageur en mangeur sensible : nourriture et pratiques de consommation dans les parties allemande et suisse des Lettres d’un voyageur russe de Nikolaï Karamzine
Authors: Baudin Rodolphe 
Published: January 2023

Portrait of the Traveler at the Dinner Table : Food in the German and Swiss Parts of Karamzin’s Letters of a Russian Traveler.
As I have shown in a previous study, the French and british parts of Karamzin’s
Letters of a Russian Traveler resort to the description of food primarily to depict national identities and to address political issues. the German and Swiss parts of the texts, which I explore in the present paper, mostly use it to characterize the new type of individual promoted by russian sentimentalism : the man of feeling. the study of the russian traveler’s food habits in Germany and Switzerland shows his endorsement of values such as moderation and cosmopolitism, as well as his taste for all things natural and his sense of sharing. It also reveals his sense of unobtrusive sophistication. these values are instrumental in defining the middle class russian nobility, whose distinctive values are popularized by Letters of a Russian Traveler.
La nourriture au service de la littérature : le banquet d’inauguration du monument à Karamzine à Simbirsk en 1845
Authors: Sapchenko Lioubov 
Published: January 2023

Celebrating Literature with Food : The Inauguration Banquet for Karamzin’s Monument in Simbirsk in 1845.
the present paper analyzes the reference to food in Mikhail Pogodin’s depiction of the banquet given by the nobility of Simbirsk on the occasion of the inauguration of the monument to nikolay Karamzin in 1845. After reminding how the different genres of classical poetry deal with the depiction of food, particularly with fish, the author shows how Pogodin used the specific features of the odic tradition, from the hyperbole to the enthusiastic tone, in his depiction of the Simbirsk banquet.