bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doors to the Homes: Signal Potential of Red Coloration of Claws in Social Hermit Crabs
Authors: Doherty C T M , Laidre M E 
Published: May 2023

SynopsisRed coloration on a signaler's body may be an informative signal in many animals. For species that inhabit architecture (e.g., burrows, nests, or other structures), certain parts of the body are more exposed than others, potentially serving as superior platforms for signaling via coloration. Yet whether animals differentially advertise red coloration on body parts that are more versus less exposed from their architecture remains to be tested. Here, we systematically quantified red coloration in social hermit crabs (Coenobita compressus). These crabs inhabit architecturally remodeled shells and have claws that visibly block the shell entrance, like doors to their homes. We hypothesized that red coloration of claws may be a signal of resource-holding potential (RHP). Consistent with this RHP signaling hypothesis, we found that within the same individuals’ bodies, exposed claws showed significantly greater red coloration than unexposed carapaces. Furthermore, larger body size predicted greater red coloration of claws. Competing hypotheses (e.g., interspecific signaling, camouflage, and UV protection), while not explicitly tested, nevertheless appear unlikely based on natural history. Red claw coloration may therefore function as a signal to conspecifics, and experiments are now needed to test recipient responses. Broadly, relative to surrounding architecture, exposed body surfaces offer rich potential as signaling platforms for coloration.
Prey-associated genetic differentiation in two species of silver fly (Diptera: Chamaemyiidae), Leucotaraxis argenticollis and L. piniperda
Authors: Havill Nathan P , Bittner Tonya D , Andersen Jeremy C , Dietschler Nicholas J , Elkinton Joseph S , Gaimari Stephen D , Griffin Brian P , Zembrzuski Deanna , Whitmore Mark C 
Published: May 2023

AbstractSympatric host-associated genetic differentiation is a prominent pattern that could lead to speciation. In insects, there are numerous examples of host-associated differentiation among herbivores that prefer different plants, and parasitoids that prefer different hosts, but few examples for specialist predators. We developed new microsatellite loci for two species of silver fly, Leucotaraxis argenticollis (Zetterstedt) and L. piniperda (Malloch) (Diptera: Chamaemyiidae), being evaluated as biological control agents for the hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae), in eastern North America where it is a nonnative pest. We obtained DNA from specimens of both fly species feeding on native A. tsugae in western North America, as well as on other western and eastern adelgid species. We performed population genetic analyses using the new loci and DNA barcode sequences. Our results confirmed east–west allopatric divergence and uncovered nested genetic differentiation associated with different adelgid prey species and their host plants in western North America for both species of silver flies. For both species, there is also evidence for a longer history of diversification in the west, with ancestral specialization of feeding on pine adelgids, which was retained after range expansion to the east. More recently, divergence to feeding on new adelgid prey species occurred in the west. Our findings are consistent with the hypothesis that host-alternating life cycles in Adelgidae may provide temporary escape from specialist predators. We discuss the implications for biological control efficacy and potential for lineage hybridization as western flies are released in the east to control A. tsugae.
Music Therapy Increases Social and Emotional Well-Being in Persons With Dementia: A Randomized Clinical Crossover Trial Comparing Singing to Verbal Discussion
Authors: Reschke-Hernández Alaine E , Gfeller Kate , Oleson Jacob , Tranel Daniel 
Published: May 2023

AbstractThe number of people living with Alzheimer’s disease and related dementias (ADRD) is growing proportional to our aging population. Although music-based interventions may offer meaningful support to these individuals, most music therapy research lacks well-matched comparison conditions and specific intervention focus, which limits evaluation of intervention effectiveness and possible mechanisms. Here, we report a randomized clinical crossover trial in which we examined the impact of a singing-based music therapy intervention on feelings, emotions, and social engagement in 32 care facility residents with ADRD (aged 65–97 years), relative to an analogous nonmusic condition (verbal discussion). Both conditions were informed by the Clinical Practice Model for Persons with Dementia and occurred in a small group format, three times per week for two weeks (six 25-minute sessions), with a two-week washout at crossover. We followed National Institutes of Health Behavior Change Consortium strategies to enhance methodological rigor. We predicted that music therapy would improve feelings, positive emotions, and social engagement, significantly more so than the comparison condition. We used a linear mixed model approach to analysis. In support of our hypotheses, the music therapy intervention yielded significant positive effects on feelings, emotions, and social engagement, particularly for those with moderate dementia. Our study contributes empirical support for the use of music therapy to improve psychosocial well-being in this population. Results also highlight the importance of considering patient characteristics in intervention design and offer practical implications for music selection and implementation within interventions for persons with ADRD.
Republican Freedom and Committees of Safety: Notes on Historicization in Critical Security Studies
Authors: Bonacker Thorsten , Carl Horst , Langenohl Andreas , Marciniak Angela L 
Published: May 2023

AbstractThis paper discusses the historical case of committees of safety and their role in three republican revolutions in early modern western political history in order to conceptually contribute to the historicization of critical security studies. These committees were significant in amalgamating republican understandings of public freedom with demands for security from tyrannical oppression, thus highlighting the constitutive role of security considerations in the formation of republican polities and republican political constituencies. Yet, they also pointed to the seemingly self-defeating effects of those committees’ practices in situations perceived as revolutionary, which regularly involved clandestine, self-legitimating, and oppressive force against “enemies of the revolution” and potential internal opposition alike, and hence undermined normative notions of republican freedom. The paper introduces an analytical triad, consisting of definition of security situation, interpretative frame, and security repertoire, which allows analyzing historical situations of securitization in full complexity while at the same time allowing inter-comparability and the modeling of dynamic invocations of security by interdependent actors. Applied to the historical narrative, two interrelated conceptual consequences for a historicization of critical security studies are derived. First, prominent strands in critical security studies will profit from studying securitization as a politically constitutive, as opposed to a merely transformative, act, precisely as securitization crystallizes in historically specific, politically constitutive organizational forms, such as committees of safety. Second, the paper complicates accounts concerning the security/freedom nexus inherited from conceptual history, analyzing the entanglement of republicanism with security reasoning from the perspective of historically situated practices.
How Can We Know What We Think We Know about Cyber Operations?
Authors: Lilli Eugenio 
Published: May 2023

Abstract
Academic research on cyber operations is characterized by an exceptional paucity of work on sources and methods of information gathering and analysis. This lack of attention can arguably hinder the future development of this increasingly important area of research and weaken its potential impact on policymaking and the wider society. This article sets to redress this undesirable situation by addressing a number of critical questions: What obstacles make collecting information on cyber operations especially hard? What are the main sources of information available to the scholar of cyber international relations? Why should we rely critically on these sources? This article's second main contribution is to advance the adoption of a research technique for the study of cyber operations based on a combination of Triangulation and Problematization called TP technique. The article also provides three detailed examples of how this research technique can be used in practice to investigate specific scenarios concerning real-world cyber operations. The article ends with a discussion of the limitations of the proposed technique while also reaffirming the benefits deriving from its application to the study of cyber operations.
An elusive dark central mass in the globular cluster M4
Authors: Vitral Eduardo , Libralato Mattia , Kremer Kyle , Mamon Gary A , Bellini Andrea , Bedin Luigi R , Anderson Jay 
Published: May 2023

ABSTRACT
Recent studies of nearby globular clusters have discovered excess dark mass in their cores, apparently in an extended distribution, and simulations indicate that this mass is composed mostly of white dwarfs (respectively stellar-mass black holes) in clusters that are core collapsed (respectively with a flatter core). We perform mass-anisotropy modelling of the closest globular cluster, M4, with intermediate slope for the inner stellar density. We use proper motion data from Gaia Early Data Release 3 (EDR3) and from observations by the Hubble Space Telescope. We extract the mass profile employing Bayesian Jeans modelling, and check our fits with realistic mock data. Our analyses return isotropic motions in the cluster core and tangential motions (β ≈ −0.4 ± 0.1) in the outskirts. We also robustly measure a dark central mass of roughly $800\pm 300 \, \rm M_\odot$ , but it is not possible to distinguish between a point-like source, such as an intermediate-mass black hole (IMBH), and a dark population of stellar remnants of extent ${\approx} 0.016\, {\rm pc} \simeq 3300\, {\rm au}$ . However, when removing a high-velocity star from the cluster centre, the same mass excess is found, but more extended (${\sim} 0.034\, {\rm pc} \approx 7000\, {\rm au}$ ). We use Monte Carlo N-body models of M4 to interpret the second outcome, and find that our excess mass is not sufficiently extended to be confidently associated with a dark population of remnants. Finally, we discuss the feasibility of these two scenarios (i.e. IMBH versus remnants), and propose new observations that could help to better grasp the complex dynamics in M4’s core.
A search for tryptophan in the gas of the IC 348 star cluster of the Perseus molecular cloud
Authors: Iglesias-Groth Susana 
Published: May 2023

ABSTRACT
We have used spectra of the Spitzer Space Telescope to conduct a search for the aromatic amino acid tryptophan in the interstellar gas of the young star cluster IC 348. For all the strongest mid-infrared (mid-IR) laboratory bands of tryptophan, we have found counterpart emission lines in the observed spectrum which are consistent in wavelength and strength with the laboratory measurements. Assuming that the detected emission lines are due to tryptophan and using the measured fluxes, we estimate a tryptophan column density in the line of sight of the core of IC 348 in the range 109–1011 cm−2. The observed emission lines are also found in the combined spectrum of &gt;30 interstellar locations obtained in diverse unrelated star-forming regions observed by Spitzer. This could be an indication that the molecule causing the emission is widespread in interstellar space. Future high spectral resolution mid-IR searches for proteinogenic amino acids in protostars, protoplanetary discs, and in the interstellar medium will be key to study an exogenous origin of meteoritic amino acids and to understand how the pre-biotic conditions for life were set in the early Earth.
On the distribution of the cold neutral medium in galaxy discs
Authors: Smith Rowan J , Tress Robin , Soler Juan D , Klessen Ralf S , Glover Simon C O , Hennebelle Patrick , Molinari Sergio , Mac Low Mordecai-Mark , Whitworth David 
Published: May 2023

ABSTRACT
The cold neutral medium (CNM) is an important part of the galactic gas cycle and a precondition for the formation of molecular and star-forming gas, yet its distribution is still not fully understood. In this work, we present extremely high resolution simulations of spiral galaxies with time-dependent chemistry such that we can track the formation of the CNM, its distribution within the galaxy, and its correlation with star formation. We find no strong radial dependence between the CNM fraction and total neutral atomic hydrogen (H i) due to the decreasing interstellar radiation field counterbalancing the decreasing gas column density at larger galactic radii. However, the CNM fraction does increase in spiral arms where the CNM distribution is clumpy, rather than continuous, overlapping more closely with H2. The CNM does not extend out radially as far as H i, and the vertical scale height is smaller in the outer galaxy compared to H i with no flaring. The CNM column density scales with total mid-plane pressure and disappears from the gas phase below values of PT/kB = 1000 K cm−3. We find that the star formation rate density follows a similar scaling law with CNM column density to the total gas Kennicutt–Schmidt law. In the outer galaxy, we produce realistic vertical velocity dispersions in the H i purely from galactic dynamics, but our models do not predict CNM at the extremely large radii observed in H i absorption studies of the Milky Way. We suggest that extended spiral arms might produce isolated clumps of CNM at these radii.
What boost galaxy mergers in two massive galaxy protoclusters at z = 2.24?
Authors: Liu Shuang , Zheng Xian Zhong , Shi Dong Dong , Cai Zheng , Fan Xiaohui , Wang Xin , Yuan Qirong , Xu Haiguang , Pan Zhizheng , Liu Wenhao , Qin Jianbo , Zhang Yuheng , Wen Run 
Published: May 2023

ABSTRACT
Characterizing the structural properties of galaxies in high-redshift protoclusters is key to our understanding of the environmental effects on galaxy evolution in the early stages of galaxy and structure formation. In this study, we assess the structural properties of 85 and 87 Hα emission-line candidates (HAEs) in the densest regions of two massive protoclusters, BOSS1244 and BOSS1542, respectively, using the Hubble Space Telescope (HST) H-band imaging data. Our results show a true pair fraction of 22 ± 5 (33 ± 6) per cent in BOSS1244 (BOSS1542), which yields a merger rate of 0.41 ± 0.09 (0.52 ± 0.04) Gyr−1 for massive HAEs with log (M*/M⊙) ≥ 10.3. This rate is 1.8 (2.8) times higher than that of the general fields at the same epoch. Our sample of HAEs exhibits half-light radii and Sérsic indices that cover a broader range than field star-forming galaxies. Additionally, about 15 per cent of the HAEs are as compact as the most massive (log (M*/M⊙) ≳ 11) spheroid-dominated population. These results suggest that the high galaxy density and cold dynamical state (i.e. velocity dispersion of &lt;400 km s−1) are key factors that drive galaxy mergers and promote structural evolution in the two protoclusters. Our findings also indicate that both the local environment (on group scales) and the global environment play essential roles in shaping galaxy morphologies in protoclusters. This is evident in the systematic differences observed in the structural properties of galaxies between BOSS1244 and BOSS1542.
Epidemiology of Gram-Negative Bloodstream Infections in the United States: Results From a Cohort of 24 Hospitals
Authors: Ince Dilek , Fiawoo Suiyini , Choudhury Rebecca , Cosgrove Sara E , Dobrzynski David , Gold Howard , Lee Jae Hyoung , Percival Kelly M , Shulder Stephanie , Sony Deepthi , Spivak Emily S , Tamma Pranita D , Nori Priya 
Published: May 2023

Abstract

Background
To address knowledge gaps in management of Gram-negative bloodstream infection, the Antibiotic Stewardship Implementation Collaborative was established consisting of programs from 24 academic and community hospitals across the United States.

Methods
A retrospective cohort study was conducted of unique adult patients with Gram-negative bloodstream infection hospitalized at participating hospitals from January to December 2019. Patient level and microbiologic data were collected via electronic medical record review with a standardized data collection form and data dictionary. Data analysis was largely descriptive. The Pearson χ2 test to compare categorical variables and the Wilcoxon rank sum test for continuous variables were used.

Results
In total, 4851 bacterial isolates from 3710 eligible unique patients were included in the cohort. Most common source of infection was the urinary tract (47.9%). Source control was achieved in 84% of cases. Escherichia coli (2471, 51.0%) was the most common Gram-negative organism recovered. Antibiogram combining isolates from all participating centers with species-level susceptibilities and source specific antibiograms for isolates from urinary, respiratory, and intraabdominal source were created. Northeast sites contributed the most extended spectrum beta-lactamase (ESBL) producing organisms (73%), but West sites had the highest percentage of ESBL producers of total isolates (16%). A statistically significant difference in percentage of ESBL-producing organisms in Whites vs. non-Whites (14.6 % and 9.5 %, respectively, P&lt;0.01) was observed.

Conclusions
While the present study was conducted pre-pandemic, it highlights the need for stewardship data collaboratives to enhance our understanding of the antimicrobial resistance patterns.
Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms
Authors: Xiong Jiachao , Chen Guodong , Liu Zhixiao , Wu Xuemei , Xu Sha , Xiong Jun , Ji Shizhao , Wu Minjuan 
Published: May 2023

Abstract

Objectives
Alopecia areata (AA) is an autoimmune-related non-cicatricial alopecia, with complete alopecia (AT) or generalized alopecia (AU) as severe forms of AA. However, there are limitations in early identification of AA, and intervention of AA patients who may progress to severe AA will help to improve the incidence rate and prognosis of severe AA.

Methods
We obtained two AA-related datasets from the gene expression omnibus database, identified the differentially expressed genes (DEGs), and identified the module genes most related to severe AA through weighted gene co-expression network analysis. Functional enrichment analysis, construction of a protein–protein interaction network and competing endogenous RNA network, and immune cell infiltration analysis were performed to clarify the underlying biological mechanisms of severe AA. Subsequently, pivotal immune monitoring genes (IMGs) were screened through multiple machine-learning algorithms, and the diagnostic effectiveness of the pivotal IMGs was validated by receiver operating characteristic.

Results
A total of 150 severe AA-related DEGs were identified; the upregulated DEGs were mainly enriched in immune response, while the downregulated DEGs were mainly enriched in pathways related to hair cycle and skin development. Four IMGs (LGR5, SHISA2, HOXC13, and S100A3) with good diagnostic efficiency were obtained. As an important gene of hair follicle stem cells stemness, we verified in vivo that LGR5 downregulation may be an important link leading to severe AA.

Conclusion
Our findings provide a comprehensive understanding of the pathogenesis and underlying biological processes in patients with AA, and identification of four potential IMGs, which is helpful for the early diagnosis of severe AA.
Effect of added calcium carbonate without and with benzoic acid on weanling pig growth performance, fecal dry matter, and blood Ca and P concentrations
Authors: Warner Alan J , DeRouchey Joel M , Tokach Mike D , Woodworth Jason C , Goodband Robert D , Gebhardt Jordan T 
Published: May 2023

Abstract
The objective of these studies was to determine the effects of increasing levels of calcium carbonate (CaCO3) with and without benzoic acid on weanling pig growth performance, fecal dry matter (DM), and blood Ca and P concentrations. In experiment 1, 695 pigs (DNA Line 200 × 400, initially 5.9 ± 0.02 kg) were used in a 28 d study. Pigs were weaned at approximately 21 d of age and randomly assigned to pens and then pens were allotted to one of five dietary treatments. Treatment diets were fed from weaning (day 0) to day 14, with a common diet fed from days 14 to 28. Dietary treatments were formulated to provide 0%, 0.45%, 0.90%, 1.35%, and 1.80% added CaCO3 at the expense of ground corn. From days 0 to 14 (treatment period), average daily gain (ADG) and G:F decreased (linear, P ≤ 0.01) as CaCO3 increased. From days 14 to 28 (common period) and for the overall experiment (days 0 to 28), there was no evidence of differences in growth performance between treatments. For fecal DM, there was a trend (quadratic, P = 0.091) where pigs fed with the highest CaCO3 diets had the greatest fecal DM. Experiment 2 used 360 pigs (DNA Line 200 × 400, initially 6.2 ± 0.03 kg) in a 38 d study. Upon arrival to the nursery facility, pigs were randomly assigned to pens and then pens were allotted to one of six dietary treatments. Dietary treatments were fed in three phases with treatment diets fed from days 0 to 10 and days 10 to 24, and a common phase 3 diet fed from days 24 to 38. Dietary treatments were formulated to provide 0.45%, 0.90%, and 1.35% added CaCO3 with or without 0.5% benzoic acid (VevoVitall, DSM Nutritional Products, Parsippany, NJ) added at the expense of ground corn. There was no evidence (P &gt; 0.05) for any CaCO3 by benzoic acid interactions. For the experimental period (days 0 to 24), there was a tendency for benzoic acid to increase ADG (P = 0.056), average daily feed intake (ADFI; P = 0.071), and gain-to-feed ratio (G:F; linear, P = 0.014) as CaCO3 decreased. During the common period (days 24 to 38), pigs previously fed benzoic acid had increased (P = 0.045) ADG and marginally increased (P = 0.091) ADFI. For the overall study, pigs fed benzoic acid had increased ADG (P = 0.011) and ADFI (P = 0.030), marginally increased G:F (P = 0.096) and final body weight (P = 0.059). Serum Ca decreased (linear, P &lt; 0.001) as CaCO3 decreased in the diet. These data show that decreasing the CaCO3 content in the nursery diet immediately after weaning may improve ADG and G:F. Dietary addition of benzoic acid may also provide beneficial effects on ADG and ADFI, regardless of dietary Ca level.