bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dietary cholesterol intake with the risk of fatal cardiovascular events in individuals with type 2 diabetes
Authors: Kuntsevich A. K. , Rymar O. D. , Mustafina S. V. , Simonova G. I. , Shcherbakova L. V. , Verevkin E. G. , Shchetinina A. O. , Malyutina S. K. 
Published: September 2023

BACKGROUND: Nutrition is one of the factors affecting the health of a population. One of the nutritional components in the diet is dietary cholesterol, which comes from meat products and eggs. To date, there is no unequivocal answer about the presence of a relationship between cholesterol consumption and the risk of cardiovascular diseases, which determines the relevance of the study of this issue.AIM: To study the association of dietary cholesterol with the risk of fatal outcomes from cardiovascular disease (CVD) in individuals with type 2 diabetes mellitus (DM2).MATERIALS AND METHODS: The baseline study was carried out within the framework of the HAPIEE project in 2003-2005. The period of observation of the cohort, incl. for persons with DM2 lasted from 2003- 2005 to December 31, 2018 and averaged 12.8 years, the average age for both sexes was 58.1±6.6 years. Data on actual nutrition were obtained from a survey of 678 participants using a questionnaire to assess the frequency of food intake and included information on 147 products. Statistical data processing was carried out using the SPSS v.13.0 application package. To compare independent paired groups of variables, the nonparametric Mann-Whitney U test was used. The risk ratio (HR) was estimated using Cox regression. The critical level of statistical significance of differences was taken at p<0.05.RESULTS: It was found that in individuals with DM2, the risk of a fatal outcome from CVD in the maximum tertile of dietary cholesterol intake/1000 kcal increased by 56% compared with controls (p=0.009). An analysis of the consumption of chicken eggs/1000 kcal in the diet showed an increase in the risk of death from CVD in the maximum tertile of by 52% (p=0.003). Consumption of meat products/1000 kcal was not associated with the risk of death from CVD (p = 0.361).CONCLUSION: In the surveyed cohort of Novosibirsk residents with a history of DM2, high dietary cholesterol levels (505 mg/day in the maximum tertile) in the diet were significantly associated with an increased risk of death from CVD. The results of this study may suggest a possible association of high-cholesterol foods with an increased risk of death in people with type 2 diabetes, pointing to the need for people with diabetes to control their dietary cholesterol levels and more optimal type of diet for this population.
Polymorphism of coagulation factor genes in patients with type 2 diabetes mellitus and chronic heart failure with retained ejection fraction
Authors: Sveklina T. S. , Shustov S. B. , Kolyubayeva S. N. , Kuchmin A. N. , Kozlov V. A. , Miroshnichenko O. A. 
Published: September 2023

BACKGROUND. Patients with type 2 diabetes mellitus (DM2) have disorders of cellular and plasma hemostasis independent of the level of glycemia, increased platelet activation, combined with microvascular angiopathy. The study of the role of genetic markers of hemostasis disorders in the formation and progression of chronic heart failure (CHF) in patients with type 2 diabetes will allow for prevention, possibly optimize treatment and improve prognosis.AIM. To reveal polymorphisms of genes of the hemostasis system in patients with type 2 diabetes mellitus and chronic heart failure with preserved ejection fraction.MATERIALS AND METHODS. The frequency of coagulation factor genetic polymorphisms was studied in patients with CHF-pEF and DM2 (52 people), CHF with reduced ejection fraction (CHF-rEF) and DM2 (49) and healthy volunteers (66), mean age 69.9±10.1 years old. DNA was isolated from venous blood according to the method of the manufacturer. Genetic polymorphisms were determined by real-time polymerase chain reaction.RESULTS. The frequencies of polymorphisms rs1799963 and rs6025 of the genes of blood coagulation factors F2 (prothrombin) and F5 (factor V of blood coagulation) in all three groups were insignificant and comparable in magnitude. In patients with CHF and DM2, the frequencies of the rs6046 polymorphism of the factor F7 gene in the heterozygous form were slightly higher (by 2.6 and 1.7 times, respectively) than in the control group, but the result was not statistically significant. The CHF-pEF and CHF-rEF groups differ in the frequencies of F13 (rs5985) and fibrinogen (rs1800790) genetic polymorphisms, but are more common in patients with CHF-rEF and DM2.CONCLUSION. Based on the results of the study, it follows that the groups of CHF-pEF and CHF-rEF differ significantly in the frequencies of polymorphisms of the studied genes, both among themselves and with the control group. The highest frequency of polymorphisms of genes, the products of which are involved in the coagulation and cellular components of hemostasis, is observed in the group of patients with DM2 and CHF-rEF.
Existence and nonexistence of nontrivial solutions for the Schrödinger-Poisson system with zero mass potential
Authors: Wang Xiaoping , Chen Fulai , Liao Fangfang 
Published: September 2023

Abstract
In this article, under some weaker assumptions on

a
>
0

a\gt 0

and

f

f

, the authors aim to study the existence of nontrivial radial solutions and nonexistence of nontrivial solutions for the following Schrödinger-Poisson system with zero mass potential

−
Δ
u
+
ϕ
u
=
−
a

∣
u
∣

p
−
2

u
+
f

(

u

)

,

x
∈

R

3

,

−
Δ
ϕ
=

u

2

,

x
∈

R

3

,

\left\{\begin{array}{ll}-\Delta u+\phi u=-a{| u| }^{p-2}u+f\left(u),& x\in {{\mathbb{R}}}^{3},\\ -\Delta \phi ={u}^{2},& x\in {{\mathbb{R}}}^{3},\end{array}\right.

where

p
∈

2
,

12

5

p\in \left(2,\frac{12}{5}\right)

. In particular, as a corollary for the following system:

−
Δ
u
+
ϕ
u
=
−

∣
u
∣

p
−
2

u
+

∣
u
∣

q
−
2

u
,

x
∈

R

3

,

−
Δ
ϕ
=

u

2

,

x
∈

R

3

,

\left\{\begin{array}{ll}-\Delta u+\phi u=-{| u| }^{p-2}u+{| u| }^{q-2}u,& x\in {{\mathbb{R}}}^{3},\\ -\Delta \phi ={u}^{2},& x\in {{\mathbb{R}}}^{3},\end{array}\right.

a sufficient and necessary condition is obtained on the existence of nontrivial radial solutions.
Unveiling Brand Convergence in Consideration Sets: The Effects of Purchase for Self or Others and Product Nature
Authors: Kikuchi Fumiaki 
Published: September 2023

Abstract
The creation of a consideration set, which constitutes a cluster of brands that a consumer contemplates buying from, plays a vital role in purchasing behavior. An understanding of its composition aids in the development of effective marketing strategies. However, existing research does not sufficiently explore brand convergence in the consideration set across consumers (BCCS). This study explored variations in BCCS according to whether the purchase is intended for self-use or as a gift, as well as the nature of the product (utilitarian or hedonic). A questionnaire survey involving 1219 participants provided data for empirical analysis. The findings revealed a higher BCCS for purchases made for self with respect to utilitarian products such as ballpoint pens, whereas hedonic products such as chocolates showed a higher BCCS when purchased for others than for self. These findings offer new insights into the underexplored area of BCCS; they suggest that desired assortment size should be tailored according to purchase intent and the nature of the targeted product (utilitarian or hedonic).
Diminutive formation in Brazilian Portuguese: a survey
Authors: Newell Cristina , Ellingson Eddington David 
Published: September 2023

Abstract
In a survey, 1,053 Brazilians provided the diminutive form of 60 test words. For example, given desconto participants provided diminutives such as descontinho or descontito. Most responses involved the suffixes -zinho and -inho. However, in many cases -zito and -ito were given as well. Statistical analysis revealed that the final phone and stress pattern of the base word were the most important predictors of diminutive form. A number of age-apparent changes were observed suggesting that certain diminutive forms may be on their way out in words with a particular phonological shape or in certain states. The state of residence, often in interaction with another predictor, proved to be an influencing factor as well. However, similar diminutivization patterns did not hold between geographically contiguous states, but between states with similarly sized populations suggesting an urban versus rural divide in Brazil.
Deletion as novel variants in VPS13B gene in Cohen syndrome: Case series
Authors: Kang Li , Ma Yixuan , Zhao Peng 
Published: September 2023

Abstract

Background
Cohen syndrome (OMIM No. # 216550) is a rare autosomal recessive disorder caused by homozygous mutation in the vacuolar protein sorting 13 homolog B (VPS13B) gene on chromosome 8q22.2. Clinical manifestations include hypermobile joints, microcephaly, intellectual disabilities, craniofacial and limb anomalies, and neutropenia. To date, more than 200 mutations of VPS13B have been reported in over 1,000 Cohen syndrome patients. This article reviews the clinical data of two cases of Cohen syndrome diagnosed by whole exome sequencing.

Results
Both children visited for psychomotor retardation. Gene detection showed a mutation in 8q22.2, NM_017890.4 Intron38 c.6940+1G > T and heterozygotic deletion of exon 3-19 of the VPS13B gene (Case 1), and a mutation in 8q22.2, NM_017890.4 Intron38 c.6940+1G > T and 8q22, NM_017890.4 Exon56 c10334_10335del in the VPS13B gene (Case 2). The variation was predicted to be pathogenic by related software, and they have not been reported.

Conclusion
Cohen syndrome should be considered in the differential diagnosis of any child with developmental retardation and neutropenia. The present study increases the mutation spectrum of the VPS13B gene and could be helpful in genetic diagnosis and genetic counseling in Cohen syndrome patients.
A symptom-based algorithm for calcium management after thyroid surgery: a prospective multicenter study
Authors: van Kinschot Caroline M J , Lončar Ivona , van Ginhoven Tessa M , Visser W Edward , Peeters Robin P , van Noord Charlotte , _ _ 
Published: September 2023

Objective
Evidence-based treatment guidelines for the management of postthyroidectomy hypocalcemia are absent. The aim of this study was to evaluate a newly developed symptom-based treatment algorithm including a protocolized attempt to phase out supplementation.

Methods
In a prospective multicenter study, patients were treated according to the new algorithm and compared to a historical cohort of patients treated with a biochemically based approach. The primary outcome was the proportion of patients receiving calcium and/or alfacalcidol supplementation. Secondary outcomes were calcium-related complications and predictors for supplementation.

Results
One hundred thirty-four patients were included prospectively, and compared to 392 historical patients. The new algorithm significantly reduced the proportion of patients treated with calcium and/or alfacalcidol during the first postoperative year (odds ratio (OR): 0.36 (95% CI: 0.23–0.54), P < 0.001), and persistently at 12 months follow-up (OR: 0.51 (95% CI: 0.28–0.90), P < 0.05). No severe calcium-related complications occurred, even though calcium-related visits to the emergency department and readmissions increased (OR: 11.5 (95% CI: 4.51–29.3), P <0.001) and (OR: 3.46 (95% CI: 1.58–7.57), P < 0.05), respectively. The proportional change in pre- to postoperative parathyroid hormone (PTH) was an independent predictor for supplementation (OR: 1.04 (95% CI: 1.02–1.07), P < 0.05).

Conclusions
Symptom-based management of postthyroidectomy hypocalcemia and a protocolized attempt to phase out supplementation safely reduced the proportion of patients receiving supplementation, although the number of calcium-related hospital visits increased. For the future, we envision a more individualized treatment approach for patients at risk for delayed symptomatic hypocalcemia, including the proportional change in pre- to post- operative PTH.
Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice
Authors: Eszlinger Markus , Stephenson Alexandra , Mirhadi Shideh , Patyra Konrad , Moran Michael F , Khalil Moosa , Kero Jukka , Paschke Ralf 
Published: September 2023

Objective
Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for hot thyroid nodules. In the first model for NAH in mice nearly all homozygous mice had developed papillary thyroid cancer by 12 months of age.

Methods
To further evaluate these mice, whole exome sequencing and phosphoproteome analysis were employed in a further generation of mice to identify any other mutations potentially responsible and to identify the pathways involved in thyroid carcinoma development.

Results
Only three genes (Nrg1, Rrs1, Rasal2) were mutated in all mice examined, none of which were known primary drivers of papillary thyroid cancer development. Wild-type and homozygous TSHR D633H knockin mice showed distinct phosphoproteome profiles with an enrichment of altered phosphosites found in ERK/mitogen-activated protein kinase (MAPK) signaling. Most importantly, phosphosites with known downstream effects included BRAF p.S766, which forms an inhibitory site: a decrease of phosphorylation at this site suggests an increase in MEK/ERK pathway activation. The decreased phosphorylation at BRAF p.S766 would suggest decreased AMP-activated protein kinase (AMPK) signaling, which is supported by the decreased phosphorylation of STIM1 p.S257, a downstream AMPK target.

Conclusion
The modified phosphoproteome profile of the homozygous mice in combination with human literature suggests a potential signaling pathway from constitutive TSHR signaling and cAMP activation to the activation of ERK/MAPK signaling. This is the first time that a specific mechanism has been identified for a possible involvement of TSH signaling in thyroid carcinoma development.
Unnecessary thyroid surgery rate for suspicious nodule in the absence of molecular testing
Authors: Mavromati Maria , Saiji Essia , Demarchi Marco Stefano , Lenoir Vincent , Seipel Amanda , Kuczma Paulina , Jornayvaz François R , Becker Minerva , Fernandez Eugenio , De Vito Claudio , Triponez Frédéric , Leboulleux Sophie 
Published: September 2023

Background
Molecular tests for suspicious thyroid nodules decrease rates of unnecessary surgeries but are not widely used due to reimbursement issues. The aim of this study was to assess the rate of unnecessary surgery performed in real-life setting for Bethesda III, IV and V nodules in the absence of molecular testing.

Method
This is a single-center retrospective study of consecutive patients undergoing fine needle aspiration cytology (FNAC) with rapid on-site evaluation between January 2017 and December 2021. Unnecessary surgery was defined as surgery performed because of Bethesda III, IV, or V results in the absence of local compressive symptoms with final benign pathology and as second surgery for completion thyroidectomy.

Results
In the 862 patients (640 females, mean age: 54.2 years), 1010 nodules (median size: 24.4 mm) underwent 1189 FNAC. Nodules were EU-TIRADS 2, 3, 4, and 5 in 3%, 34%, 42%, and 22% of cases, respectively. FNAC was Bethesda I, II, III, IV, V, and VI in 8%, 48%, 17%, 17%, 3%, and 6%, respectively. Surgery was performed in 36% of Bethesda III nodules (benign on pathology: 81%), in 74% of Bethesda IV nodules (benign on pathology: 76%) and in 97% of Bethesda V nodules (benign on pathology: 21%). Surgery was considered unnecessary in 56%, 68%, and 21% of patients with Bethesda III, IV, and V nodules, respectively.

Conclusion
In this real data cohort surgery was unnecessary in more than half of patients with Bethesda III and IV nodules and in 21% of patients with Bethesda V nodules.
PENGEMBANGAN BAHAN AJAR BERBASIS KEMAMPUAN PEMECAHAN MASALAH PADA MATERI KESEBANGUNAN DAN KEKONGRUENAN
Authors: Kurniawati Lia , Musyrifah Eva , Narulita Utari 
Published: September 2023

AbstractThis study aims to develop teaching materials based on problem-solving abilities in the materials of similarity and congruence at SMP/MTS. Problem solving ability is the ability to solve mathematical problems that are non-routine or procedural as usual which require deeper thinking in solving them. The teaching materials chosen are in the form of student worksheets (LKS). The trial subjects were taken based on nonprobability sampling techniques, specifically purposive sampling, namely 13 students one of the SMP/MTS level schools in Pamulang. The method used in this research is the ADDIE model development research method (Analysis, Design, Development, Implementation, Evaluation). The results showed that the teaching materials developed fell into the very feasible category with a percentage score of 87.11% according to experts consisting of 3 lecturers in the mathematics education department at UIN Syarif Hidayatullah Jakarta and 5 mathematics teachers from several SMP/MTS. The results of the limited trial for students who obtained a percentage score of 80.92% were categorized as feasible by the students. Keywords: Problem Solving Ability, Similarity and Congruence Materials, ADDIE Development Model. AbstrakPenelitian ini bertujuan untuk mengembangkan bahan ajar berbasis kemampuan pemecahan masalah pada Materi Kesebangunan dan Kekongruenan SMP/MTS. Kemampuan pemecahan masalah adalah kemampuan dalam menyelesaikan permasalahan matematika yang bersifat non-rutin atau tidak sesuai prosedural seperti biasa yang dalam menyelesaikannya memerlukan pemikiran yang lebih mendalam. Bahan ajar yang dipilih berupa Lembar Kerja Siswa (LKS). Subjek penelitian diambil berdasarkan teknik nonprobability sampling, tepatnya purposive sampling yaitu 13 orang siswa kelas IX salah satu sekolah tingkat SMP/MTS di Pamulang. Metode yang digunakan dalam penelitian ini adalah metode penelitian pengembangan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Hasil penelitian menunjukkan bahwa bahan ajar yang dikembangkan masuk ke dalam kategori sangat layak dengan skor persentase 87,11% menurut para ahli yang terdiri dari 3 orang dosen jurusan pendidikan matematika UIN Syarif Hidayatullah Jakarta dan 5 orang guru matematika yang berasal dari beberapa sekolah tingkat SMP/MTS. Hasil uji coba terbatas kepada siswa memperoleh skor persentase 80,92% dikategorikan layak oleh siswa. Kata kunci: Kemampuan Pemecahan Masalah, Matei Kesebangunan dan Kekongurenan, Model Pengembangan ADDIE.
CROSS FLOW IN THE WELL
Authors: Filippov A.I. , Zelenova M.A. , Akhmetova O.V. , Levina T.M. , Gubajdullin R.G. 
Published: September 2023

The article considers the problem of pressure fields in a system consisting of two perforated reservoirs penetrated by one well, providing a hydrodynamic connection between them. One-dimensional equations of piezoconductivity in radial geometry are used to describe the pressure fields in the reservoirs. The hydrodynamic connection between the layers through the well is given by an integro-differential equation obtained on the basis of mass balance and Darcy's law.It is assumed that there are no pressure disturbances at the initial moment of time and in the parts of the reservoirs remote from the well. At the boundaries between the well and the reservoirs for the time t>0, the conditions for equal pressures are set. Exact analytical solutions describing pressure fields in reservoirs and wells are constructed in the Laplace–Carson image space. Computational experiments for modeling pressure fields and flows were carried out using the Stehfestand den Iseger algorithms, which made it possible to eliminate the time-consuming procedure of transition to the original space. The joint use of these algorithms made it possible to increase the reliability and accuracy of the results of field calculations, since direct control based on analytical formulas in the originals is difficult.
The purpose of computational experiments is to determine the conditions for the existence of interlayer cross flows and their temporal dynamics in the absence of production from the well. Calculations are made for the case when reservoir characteristics of reservoirs are the same. For definiteness, it is assumed that the reservoir, which occurs at a shallower depth, is high-pressure. It is shown that in the absence of production from the well, after some time, an equilibrium pressure that changes slightly with time is established in the wellbore, equal to the average hydrostatic pressure of the lower and upper reservoirs. At the same time, in the region of short times, the flow rate of each reservoir depends on the value of the initial hydrostatic pressure in the well, and in the region of long times, this pressure does not affect the dynamics of interlayer flows. It has been established that the total flow rate of reservoirs is equal to zero only for times longer than the relaxation time. It is noted that the pressure relaxation time in the well increases with a decrease in reservoir permeability.
Consumo de linaza molida para la reducción de peso corporal en personas con exceso de peso
Authors: Ruiz Pineda Adriana Marcela , Gaviria Gómez Berta Lucia , Arango Alzate Catalina María , Molina Castaño Carlos Federico , López Marín Beatriz Estella 
Published: September 2023

Objetivo: describir los cambios en el peso, el porcentaje de grasa corporal y la ingesta de alimentos de personas con sobrepeso y obesidad, que consumieron 30 g diarios de linaza molida durante ocho semanas y reportar su tolerancia a este tratamiento. Materiales y métodos: se intervino un grupo de 10 participantes adultos con exceso de peso, voluntarios, quienes consumieron una dosis diaria de 30 g de linaza molida durante ocho semanas y a quienes se les solicitó que no modificaran su ingesta usual de alimentos y que no cambiaran su patrón de actividad física durante la intervención. Se midieron variables antropométricas, de consumo de alimentos y de actividad física en las semanas cero, cuatro y ocho, y se evaluó semanalmente la aceptación y tolerancia al tratamiento. Resultados: al finalizar la intervención los participantes no tuvieron cambios significativos en su peso (p=0,610), ni en su porcentaje de grasa corporal (p=0,866). No se presentaron efectos adversos. Conclusión: el consumo de 30 g diarios de linaza molida durante ocho semanas, sin hacer reducciones en el consumo calórico y sin incrementos en la realización de actividad física, no permite reducciones de peso corporal en personas con exceso de peso.
Aspectos socioculturales y técnico-nutricionales en la alimentación de un grupo de adultos mayores del centro gerontológico Colonia de Belencito de Medellín-Colombia
Authors: Franco Giraldo Fabio Andrés , Arboleda Montoya Luz Marina 
Published: September 2023

Objetivo: interpretar los aspectos socioculturales y técnico-nutricionales de la alimentación de un grupo de adultos mayores del centro gerontológico Colonia de Belencito. Materiales y métodos: el estudio se fundamentó en el enfoque de investigación cualitativa y se utilizó como perspectiva metodológica la etnografía de tipo particularista o enfocada. Las técnicas para la recolección de la información fueron la observación participante, la entrevista en profundidad, la entrevista semiestructurada y los grupos de discusión. Resultados: entre los principales hallazgos se encontró que el concepto de adulto mayor y los aspectos socioculturales de las directrices políticas que rigen la alimentación en la institución, no corresponden a lo que se propone para un proceso de envejecimiento activo; las especificaciones técnicas para el diseño de la minuta alimentaria se enmarcan en un modelo medicalizado de la alimentación; los adultos mayores manifestaron un gusto marcado por la alimentación tradicional, la cual dentro de los procesos de socialización marca una identidad y un entorno de significaciones alimentarias.