bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between fibroblast growth factor receptor mutation, programmed death ligand-1 expression and survival in urinary bladder cancer based on real-world data
Authors: Revesz Janos , Posfai Boglarka , Pajor Laszlo , Papdan Timea , Varga Linda , Paczona Viktor R. , Varga Zoltan , Sukosd Farkas , Maraz Aniko 
Published: April 2023

Background: Programmed cell death (PD)-1/PD-ligand 1 (PD-L1) inhibitors have made a breakthrough in the therapy of advanced urothelial bladder cancer (UBC). The impact of Fibroblast Growth Factor Receptor 3 (FGFR3) mutation on the effectiveness of PD-L1 treatment remains still unclear. Objective: Our study aimed to investigate the frequency of FGFR mutations at different tumor stages, and their relation to PD-L1 status and survival.Methods: 310 patients with urothelial bladder cancer and subsequent radical cystectomy were included in a retrospective study over a 10-year study period at the University of Szeged, Hungary. FGFR3 mutations from the most infiltrative areas of the tumor were analyzed by targeted next-generation sequencing and PD-L1 (28-8 DAKO) tests (tumor positive score -TPS and combined positives score–CPS). In T0 cases FGFR3 mutations were analyzed from the earlier resection samples. Survival and oncological treatment data were collected from the National Health Insurance Fund (NHIF). Neoadjuvant, adjuvant and palliative conventional chemotherapies were allowed; immunotherapies were not. The relationship between the covariates was tested using chi-square tests, and survival analysis was performed using the Kaplan-Meier model and Cox proportional hazards regression.Results: PD-L1 and FGFR could be tested successfully in 215 of the 310 UBC samples [pT0cyst 19 (8.8%); St.0-I 43 (20%); St.II 41 (19%); St.III-IV 112 (52%)]. Significant pairwise dependency was found between tumor stage, FGFR3 mutation status and PD-L1 expression (p &lt; 0.01). Samples with FGFR mutation were more common in less advanced stages and were also less likely to demonstrate PD-L1 expression. The effect of all investigated factors on survival was found to correlate with tumor stage.Conclusion: FGFR alteration frequency varied between the different stages of cancer. Higher positivity rates were observed at early stages, but lower levels of PD-L1 expression were detected in patients with FGFR mutations across at all stages of the disease.
Chinese Cabbage BrCAP Has Potential Resistance against Plasmodiophora brassicae
Authors: Zou Jiawei , Gao Shiqi , Zhang Bo , Ge Wenjie , Zhang Jing , Ji Ruiqin 
Published: April 2023

Clubroot disease caused by Plasmodiophora brassicae Woronin (P. brassicae) has seriously influenced the production of Brassica rapa crops, but the interaction mechanism between P. brassicae and Brassica rapa is not clear. In our previous study, a differentially expressed protein, G15, was found between the roots of Chinese cabbage inoculated and un-inoculated with P. brassicae through two-dimensional electrophoresis (2-DE) and mass spectrometry, and G15 was matched with Bra011464. In this study, Bra011464 was found to have a 94% percent identity with Arabidopsis thaliana CAP, named BrCAP. The expression of BrCAP was the highest in the root compared with the stems and leaves of Chinese cabbage, and its expression in the roots of Chinese cabbage inoculated with P. brassicae was significantly higher than that in the control. The results were verified by real-time quantitative polymerase chain reaction (RT-qPCR) and in situ hybridization. Subcellular localization showed that BrCAP was localized on chloroplasts of leaf epidermal cells. To verify the function of BrCAP, it was found that the Arabidopsis thaliana mutant cap was more susceptible to infection with P. brassicae than the wild type (WT), which suggested that BrCAP has a potential role in the resistance progress of Chinese cabbage to P. brassicae.
DESIGNING OF TECTONIC FORM OF CLOTHES IN THE PROCESS OF TEACHING PROFESSIONAL EDUCATION SPECIALISTS
Authors: Orlova N. 
Published: April 2023

The article considers the process of teaching the artistic designing of clothes which necessarily involves the study of technological properties of materials, especially the ability to form and deform. Clothes are made with different materials: fabrics, knitwear, non-woven fabrics, etc., and it is the source material that determines the method of forming, and the methods of forming clothes – the stability of clothing and its individual parts. The tectonically perfect shape of a suit is a harmonious ratio of shape, construction, and material, as well as the implementation of the function of the direct purpose of clothes. The tectonic approach to designing clothes increases the aesthetic level of light industry products, and their quality, which is achieved by taking into account the properties of fabrics. In classes on designing a new product, the main task of students is to create a form that will fully reveal the content of the product.
The first stage of designing a tectonic form of clothes is to determine its functional purpose, which determines the basic principles of organizing the spatial form of the product. It is followed by determining the properties of fabrics and searching for a design solution for the projected tectonic three-dimensional shape. The most informative is the classification of fabrics according to their functional purpose since it combines both the physical and mechanical properties of fabrics (mandatory for the selected type of clothing), as well as the characteristics of the raw material composition, weave, and other properties. The usage of the principles of the tectonic formation while designing sewing products makes it possible to efficiently carry out design activities and create harmonious solutions in clothes.
THE USAGE OF PROJECT-BASED LEARNING TECHNOLOGY IN THE PROCESS OF TRAINING MASTERS OF VOCATIONAL EDUCATION
Authors: Yaprynets T. , Antonets A. 
Published: April 2023

The article substantiates the theoretical and methodological aspects of the usage of project learning technology in the course of training masters of vocational education. The advantages of using project-based learning are noted, which stimulates the interest of higher education students in solving various production tasks and situations based on their previous experience, creates conditions for increasing students’ motivation and creative self-realization, and develops their intellectual abilities.
The pedagogical conditions for the implementation of project activities by future teachers of vocational education are highlighted, taking into account their level of training and individual capabilities. Classifications of projects are highlighted according to the following essential characteristics: dominant activity, subject-matter areas; the nature of relationships and coordination of the project; the number of project participants, and its duration. Methodological aspects and stages of project implementation in the course of mastering the basics of pedagogical management are revealed. Conclusions have been made regarding the fact that the project learning technology is a modern tool for the personality’s comprehensive development in the course of training future masters of professional education. The usage of technology creates opportunities to combine traditional teaching methods with active and interactive ones. It makes it possible to actualize, integrate and practice acquired knowledge, abilities, and skills. While using project learning technology, the teacher can use a set of search, research, and creative didactic tools. The usage of project technology in the course of master of vocational education training creates comprehensive opportunities for the formation of professional knowledge and skills, abilities and skills of self-organization in one’s pedagogical activities, development of critical thinking, the ability to search for information and innovative activities.
PREPARATION OF FUTURE TEACHERS OF NATURAL SCIENCES FOR WORK IN THE NEW UKRAINIAN SCHOOL
Authors: Hrytsai N. 
Published: April 2023

The article shows the main trends in the development of natural education worldwide. Methodical features of teaching natural subjects in the conditions of the New Ukrainian School are revealed. Emphasis is placed on the availability of various model curricula of integrated courses, i.e., «Natural Sciences,» «Knowing Nature,» and «Environment.» The necessity of teacher training for work in the New Ukrainian School is substantiated. The relevance of the specialty 014.15 Secondary education (Natural Sciences) in higher education institutions is confirmed. Educational training programs for future teachers of natural sciences, physics, chemistry, and biology are analyzed. The main methodological guidelines in the teaching of natural sciences are outlined: implementation of an integrative approach to the content of courses through the introduction of special integrated courses in the field of natural sciences, using integrated tasks (physics + chemistry + biology + geography), conducting integrated lessons and extracurricular activities; the use of competence-oriented tasks that model standard or non-standard life and professional situations and require students to independently engage in cognitive activities, as well as personal qualities that determine readiness for such activities; implementation of educational projects; implementation of a research approach using methods similar to the scientific activity of a scientist (observation, experiment, formulation of a hypothesis, substantiation of a theory, processing of data, formulation of conclusions, design of subsequent studies); use of elements of STEM education, in particular, making; application of various digital computer technologies, equipment of specialized offices with multimedia projectors, interactive whiteboards, tablets, etc.; formative assessment of students’ knowledge.
Each of these guidelines is described in detail. Thus the essence of integrative and research approaches is revealed, the peculiarities of competence-oriented tasks and formative assessment are clarified, digital resources of natural sciences are indicated, and STEM education in general and one of its directions is characterized. Nowadays, significant changes are taking place in school science education due to the implementation of the conceptual provisions of the New Ukrainian School. All in all, it is crucial to prepare future science teachers for the introduction of new integrated courses in the field of science education. The mentioned issues can be systematically considered during the study of the educational discipline «Methodology of Teaching Integrated Courses in Natural Sciences.»
FIRST-YEAR STUDENTS’ PROFESSIONAL CULTURE FORMATION IN THE COLLEGES OF ARTS CULTURE BY MEANS OF DISCIPLINES OF DECORATIVE AND APPLIED DIRECTION ORIENTATION
Authors: Tetianin I. 
Published: April 2023

Analysis of culture as an anthropological phenomenon shows that culture is congruent with human beings. Historically, the cultural phenomenon has always reflected processes related to education, enlightenment, formation, and development of a person. Without education and training, without the active transmission of new achievements of human culture to new generations, the movement of history would be impossible. Therefore, the article updates the expediency of using profile subjects from the specialty «Decorative and Applied Arts» as a component of attracting first-year students of art educational institutions to the formation of their own professional culture.
The main art subjects and tasks (from simple to complex) are introduced into the educational context of future artist-decorative and applied arts teacher training are considered. Students are involved in working on the material together with the teacher. The student learns all the subtleties of mastery in practical work. In the mentioned direction, the concepts of «competence» and «mastery» are distinguished. It is stated that professional skill involves comprehensive knowledge of production or any other professional process, the ability to implement it, to set it in motion.
Since the development of culture and education are processes that are carried out mainly in parallel, synchronously, and interconnected, the essence of the meaning of the technology of situational learning (case method), which consists in modeling a specific situation that occurs in regional professional practice, has been clarified. Based on that, a didactic package of tasks for solving a certain issue is developed. The case method for first-year students is specific learning situations that are specially developed based on actual material for further study in classes.
STUDENTS’ DESIGN ACTIVITY AS A MEANS OF FORMING ECOLOGICAL AND AESTHETIC COMPETENCES
Authors: Tytarenko O. 
Published: April 2023

The article clarified the need for the formation of pupils’ and student youth’s technological artistic and project competence based on the modern vision of reforming national education in the context of the world and European civilization trends in the development of society (increasing the intellectual potential of nations, all-round development of the individual as the highest value of society and avoiding environmental hazards and disasters caused by military actions).
The study aimed to choose the multifaceted nature of the formation of future technology teachers’ ecological and aesthetic competencies by studying and systematizing aspects of national experience, summarizing the theoretical ideas and practices of leading design specialists, opportunities for design education, and design activities of future specialists.
The support of the scientific position regarding the fact that the means and methods of design activity can be used to protect nature from the standpoint of cultural values, to fight for the environmental cleanliness of construction and processing materials, to improve the condition of the subject environment of many spheres of people’s lives, led to the selection of design education tools for the educational discipline «Fundamentals of Landscape Design», proposed for future teachers of the educational field «Technology» to study. These means include awareness of the socially significant functions of design, knowledge of socially essential tasks of design activity, the structure of future technology teachers' ecological and aesthetic competencies based on design education, and ways to increase student youth’s ecological and aesthetic competencies in design activities together with the teacher.
From the perspective of the research, the need to use the national characteristics of Ukrainian people’s culture in the educational process of secondary education, their ideas about the aesthetics of nature and man, and the ability to aesthetically improve the living environment by means of design are determined.
ETHNOGRAPHIC ASPECT IN THE CONTENT OF FUTURE SPECIALISTS’ TRAINING AND ETHNOCULTURAL ACTIVITIES
Authors: Petrenko L. 
Published: April 2023

The purpose of the article is to analyze the prospects for the ethnographic aspect usage as a component of the content of higher education and ethno cultural activities of future specialists. Certain aspects of the study of disciplines from the standpoint of Ukrainian ethnology are highlighted. The importance of using materials from Ukrainian ethnology for the spiritual development and education of youth is emphasized. It is emphasized that understanding the formation of national self-identification as a result of the appropriate provision of the professional training process is one of the most significant competencies of the 21st century. The possibilities of ethnology for updating the content of teaching professional disciplines for future specialists in the humanitarian field have been identified.
The issue’s relevance is explained by the need to form a young person’s worldview based on national and universal spiritual values, respect for the achievements of national culture, and the use of rich folk traditions in the course of ethno cultural activities. One of the main tasks of reforming the modern education system is to provide a solution to the issue of the formation of civil society as a community ready to participate in the processes of state formation and to protect democratic values, the territorial integrity of the country since without the affirmation of democratic values in the consciousness of the individual, an active civic position formation, moral responsibility for the fate of the country, education of beliefs, feelings of love and respect for the cultural and historical past of Ukraine, solving the task of modern transformation of Ukrainian society is not possible.
Ethnology is considered to be an integrative component of the content of education in secondary and higher education institutions; the need for a more systematic approach to the content of the educational material of Ukrainian-cultural disciplines, which contain a powerful formative and educational potential, which contributes to the process of self-awareness of the Ukrainian people, the establishment of Ukraine as a political nation and an independent state, is emphasized.
TEACHING PHARMACEUTICAL CHEMISTRY TO FUTURE MASTERS OF PHARMACY IN A SCIENTIFIC AND PEDAGOGICAL DISCOURSE
Authors: But I. 
Published: April 2023

The article reviews the specifics of teaching pharmaceutical chemistry to future pharmacists in domestic institutions of higher medical (pharmaceutical) education from the standpoint of scientific and pedagogical discourse. The review is based on the analysis of the leading groups of sources and work experience of the Department of Drug Chemistry and Medicinal Toxicology of the Bogomolets National Medical University. The study reveals the growing interest of stakeholders, medical university teachers, and educational service consumers in teaching chemical disciplines, particularly pharmaceutical chemistry, as the introduction of distance learning, which was actualized in the settings of the COVID-19 pandemic and martial law in Ukraine. In the context of distance learning of future pharmacists, innovative technologies – workshops; simulation training; case methods; smart technologies; problem-based learning; video visualization, etc – in the educational process are being improved. New areas of research have become the following: improving the quality of the educational process; using digital tools in the teaching of chemical disciplines.
The search for answers to the question of improving the efficiency of the organization of independent work of future masters of pharmacy remained relevant for scientists, employers, and participants of the educational process of institutions of higher medical (pharmaceutical) education in Ukraine; implementation of best international practices of training future specialists of the pharmaceutical industry; boosting the practice-oriented component in the training of future pharmacists, in particular during the delivery of pharmaceutical chemistry; fostering ‘soft skills’ and ‘hard skills’ (professional knowledge and skills) in students of higher medical (pharmaceutical) education institutions.
Sur les fluctuations de période annuelle de la rotation de la Terre
Authors: Laurent Mariette 
Published: April 2023

Développement de la note publiée sous le même titre dans le Bulletin de l’Académie royale de Belgique (Classe des Sciences) de décembre 1949.
Relevés, d’après Napier Shaw, de la répartition des pressions pour tous les mois de l’année. Valeurs correspondantes des moments d’inertie de l’atmosphère. Résultats numériques relatifs aux seules aires occupées par les terres émergées (schéma de Prey). Indications fournies par ces résultats.
Une propriété générale du tourbillon dans le mouvement permanent d’un fluide parfait
Authors: Lahaye Edmond 
Published: April 2023

On considère le mouvement permanent d’un fluide parfait en contact avec une surface (S) non cylindrique, simplement connexe et sans singularités réelles, mouvement défini par les suites de valeurs que les composantes de la vitesse prennent sur (S). De la condition que la vitesse doit être tangente à (S) résulte que (S) est une surface caractéristique pour certaines des équations du mouvement. L’étude approfondie de cette propriété permet d’établir, dans le cas général que : 1) le tourbillon est proportionnel à la vitesse ; 2) le facteur de proportionnalité est kp, k étant constant dans tout le fluide, ou nul.
Si la surface (S) est cylindrique, le tourbillon est nul dans le cas général. Il existe cependant des mouvements particuliers dans lesquels le tourbillon est parallèle aux génératrices de (S), mais dans ces cas, les composantes de la vitesse ne peuvent être choisies a priori sur (S).
La sécrétion externe et interne des glandes salivaires postérieures des Céphalopodes octopodes
Authors: Bacq Zénon Marcel , Ghiretti Fr. 
Published: April 2023

I) Grâce à la technique de perfusion des glandes salivaires isolées de trois Céphalopodes octopodes (O. macropus, O. vulgaris, et Eledone moschata), nous avons pu :
1° étudier comparativement les modalités de la sécrétion externe, les propriétés physicochimiques et physiologiques des salives de ces trois espèces ;
2° démontrer que, au cours de l’excitation nerveuse de ces glandes, des dérivés phénoliques (vraisemblablement des amines) passent dans le perfusat à concentration telle que ce perfusat acquiert des propriétés physiologiques particulières (excitation du cœur et des vaisseaux). La ou les amines phénoliques dont dispose Eledone moschata et surtout l’O. vulgaris, sont beaucoup plus actives physiologiquement que celle synthétisée par O. macropus dont les propriétés sont comparables à celles de la tyramine.
II) La discussion montre que les glandes salivaires postérieures des Céphalopodes sont bien des glandes à sécrétion interne, homologues de la surrénale des Vertébrés.
Note sur le système nerveux de l’Hydre
Authors: Van Gansen Paulette 
Published: April 2023

Le système nerveux de l’Hydre est formé de protoneurones.
Ce sont des cellules dont les prolongements ramifiés sont variables en nombre et en longueur. Dans l’ectoderme, où les cellules multipolaires dominent, ces prolongements s’anastomosent en un plexus de dispersion homogène au sein duquel l’influx nerveux n’est pas polarisé.
Il n’y a pas de centre coordonnateur. L’endoderme présente de nombreux protoneurones presque toujours bipolaires et apparemment isolés. L’hypothèse de l’existence d’un plexus unique neuro-musculaire est discutée.
L’Hydre possède des cellules sensorielles tant dans l’ecto- que dans l’endoderme. Elles ne sont nombreuses que dans les régions glandulaires : lèvres hypostomiales endodermiques, sole pédieuse ectodermique. Les multiples terminaisons protoneurales qui s’intriquent dans le feuillet externe contribuent à déterminer l’évidente excitabilité de l’Hydre.
Influence des impuretés contenues dans les hormones de synthèse (qualité technique) sur la croissance d’organismes végétaux inférieurs
Authors: Bouillenne Raymond Léon Eugène , Bouillenne-Walrand M. 
Published: April 2023

Les auteurs ont mis en évidence et isolé un corps manifestant des activités mycocidales jusqu’à des dilutions de 1 pour 57.000 (20γ par c. c., environ). A la dilution de 1 pour 20.000, il inhibe totalement la croissance des 17 organismes expérimentés (Champignons et Levures) ; à 1 pour 45.000, il réagit sélectivement sur certaines espèces dont il arrête toute croissance.
Ce corps se trouve à l’état d’impureté dans les sels sodiques de l’acide 2-4-5 Trichlorophénoxyacétique, en qualité technique, de diverses origines.
L’action toxique de ce corps se manifeste aussi bien au pH 4.9, qu’au pH 6.9 et ne comporte aucune synergie ni antagonisme avec le 2-4-5 T. pur, auquel il est mélangé.
Des essais cliniques en cours étudient ses propriétés thérapeutiques. Il est proposé de le nommer Trichlorex.