bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in voice characteristics in patients with heart failure (VENTURE) in Switzerland: Protocol for a longitudinal observational pilot study
Authors: Wu Fan , Nägele Matthias , Cleres David , Haider Thomas , Fleisch Elgar , Ruschitzka Frank , Flammer Andreas , Barata Filipe 
Published: April 2023

Introduction
Heart Failure (HF) is a major health and economic issue worldwide. HF-related expenses are largely driven by hospital admissions and re-admissions, many of which are potentially preventable. Current self-management programs, however, have failed to reduce hospital admissions. This may be explained by their low predictive power for decompensation and high adherence requirements. Slight alterations in the voice profile may allow to detect decompensation in HF patients at an earlier stage and reduce hospitalizations. This pilot study investigates the potential of voice as a digital biomarker to predict health status deterioration in HF patients.

Methods and analysis
In a two-month longitudinal observational study, we collect voice samples and HF-related quality-of-life questionnaires from 35 stable HF patients. Patients use our developed study application installed on a tablet at home during the study period. From the collected data, we use signal processing to extract voice characteristics from the audio samples and associate them with the answers to the questionnaire data. The primary outcome will be the correlation between voice characteristics and HF-related quality-of-life health status.

Ethics and dissemination
The study was reviewed and approved by the Cantonal Ethics Committee Zurich (BASEC ID:2022-00912). Results will be published in medical and technical peer-reviewed journals.
Healthcare resource utilisation and cost of pneumococcal disease from 2003 to 2019 in children ≤17 years in England
Authors: Mohanty Salini , Podmore Bélène , Cuñado Moral Ana , Matthews Ian , Sarpong Eric , Azpeitia Agueda , Qizilbash Nawab 
Published: April 2023

Objective
To estimate healthcare resource utilisation (HCRU) and costs associated with pneumococcal disease (PD) in children aged ≤17 years in England from 2003–2019.

Methods
A retrospective study in children aged ≤17 years was conducted using the Clinical Practice Research Datalink Gold primary care database and Hospital Episodes Statistics Admitted Patient Care database from 2003–2019. Episodes of invasive pneumococcal disease (IPD) were identified in hospital, pneumococcal pneumonia (PP) and all-cause pneumonia (ACP) episodes in primary care and in hospital, and acute otitis media (AOM) episodes in primary care. General practitioner (GP) visits and inpatient admission yearly rates were calculated per 1,000 persons. The average inpatient and primary care cost per episode were calculated. The Mann-Kendall test was used to assess monotonic time trends.

Results
1,500,686 children were followed from 2003–2019. The highest average inpatient cost per episode [£34,255 (95%CI 27,222–41,288)] was in IPD, followed by ACP [£3,549 (95%CI 3,405–3,693)] and PP [£1,498 (95%CI 1,153–1,843)]. The highest primary care costs per episode were in AOM [£48.7 (95%CI 48.7–48.7)], followed by PP [£38.4 (95%CI 37.0–39.7)] and ACP [£28.6 (95%CI 28.2–29.1)]. The highest inpatient admission and GP visits yearly rates were observed in children aged <2 years. Across years, a significant decrease in GP visits yearly rates was observed for PP, ACP and AOM in children overall (p-value<0.001). A decrease in primary care costs was observed for ACP (p-value<0.001). There was an increasing trend in AOM primary care costs (p-value<0.001). No significant trends were observed in inpatient admission yearly rates in PP, ACP or IPD and inpatient costs per episode in PP, ACP and IPD.

Conclusion
From 2003–2019, primary care HCRU and costs decreased (except for PP cost), but no trends in inpatient HCRU and costs were observed. The economic burden of pneumonia, IPD and AOM remains substantial in children aged ≤17 years in England.
Orthogeriatric co-management for older patients with a major osteoporotic fracture: Protocol of an observational pre-post study
Authors: Janssens Sigrid , Dejaeger Marian , Sermon An , Fagard Katleen , Cerulus Marie , Cosyns Heidi , Flamaing Johan , Deschodt Mieke 
Published: April 2023

Background
Osteoporotic fractures are associated with postoperative complications, increased mortality, reduced quality of life, and excessive costs. The care for older patients with a fracture is often complex due to multimorbidity, polypharmacy, and presence of geriatric syndromes requiring a holistic multidisciplinary approach based on a comprehensive geriatric assessment. Nurse-led geriatric co-management has proven to prevent functional decline and complications, and improve quality of life. The aim of this study is to prove that nurse-led orthogeriatric co-management in patients with a major osteoporotic fracture is more effective than inpatient geriatric consultation to prevent in-hospital complications and several secondary outcomes in at least a cost-neutral manner.

Methods
An observational pre-post study will be performed on the traumatology ward of the University Hospitals Leuven in Belgium including 108 patients aged 75 years and older hospitalized with a major osteoporotic fracture in each cohort. A feasibility study was conducted after the usual care cohort and prior to the intervention cohort to measure fidelity to the intervention components. The intervention includes proactive geriatric care based on automated protocols for the prevention of common geriatric syndromes, a comprehensive geriatric evaluation followed by multidisciplinary interventions, and systematic follow-up. The primary outcome is the proportion of patients having one or more in-hospital complications. Secondary outcomes include functional status, instrumental activities of daily living status, mobility status, nutritional status, in-hospital cognitive decline, quality of life, return to pre-fracture living situation, unplanned hospital readmissions, incidence of new falls, and mortality. A process evaluation and cost-benefit analysis will also be conducted.

Discussion
This study wants to prove the beneficial impact of orthogeriatric co-management in improving patient outcomes and costs in a heterogenous population in daily clinical practice with the ambition of long-term sustainability of the intervention.

Trial registration
International Standard Randomised Controlled Trial Number (ISRCTN) Registry: ISRCTN20491828. Registered on October 11, 2021, https://www.isrctn.com/ISRCTN20491828.
Investigating donor human milk composition globally to develop effective strategies for the nutritional care of preterm infants: Study protocol
Authors: Perrin Maryanne T. , Mansen Kimberly , Israel-Ballard Kiersten , Richter Scott , Bode Lars , Hampel Daniela , Shahab-Ferdows Setareh , Allen Lindsay H. , Maggio Francisca Cofré , Njuguna Emily , Tran Hoang Thi , Wesolowska Aleksandra 
Published: April 2023

Background
Globally, almost 15 million infants are born prematurely each year, disproportionately affecting low and middle-income countries. In the absence of mother’s milk, the World Health Organization recommends using donor human milk (DHM) due to its protective effect against necrotizing enterocolitis, a life-threatening intestinal disorder. The use of DHM is increasing globally, with many low and middle-income countries integrating donor milk banks into their public health strategies to reduce neonatal mortality, yet very little is known about the nutritional composition of DHM. Additional knowledge gaps include how DHM composition is influenced by milk banking practices, and whether preterm nutrient recommendations are achieved when DHM is used with commercially available fortifiers.

Methods
We designed a multi-site study with eight geographically diverse milk bank partners in high, middle, and low-income settings that will examine and compare a broad range of nutrients and bioactive factors in human milk from 600 approved milk bank donors around the world to create comprehensive, geographically diverse nutrient profiles for DHM. We will then simulate the random pooling of 2 to 10 donors to evaluate the impact of pooling as a potential strategy for milk banks to manage nutrient variability in DHM. Finally, we will evaluate whether commercially available fortifiers meet nutrient recommendations when used with DHM.

Discussion
We expect that results from this study will improve nutritional care globally for the growing number of preterm infants who receive donor human milk.
Finite element method on topology optimization applied to laminate composite of fuselage structure
Authors: Aribowo Agus , Adhynugraha Muhammad Ilham , Megawanto Fadli Cahya , Hidayat Arif , Muttaqie Teguh , Wandono Fajar Ari , Nurrohmad Abian , Chairunnisa  , Saraswati Sherly Octavia , Wiranto Ilham Bagus , Al Fikri Iqbal Reza , Saputra Muhammad Dito 
Published: April 2023

Abstract
This research applies a numerical study of topology optimization of laminate composite structures by using a finite element method (FEM). In this methodology, the plies orientation is excluded from the optimization. The geometry-based optimization from frames of a MALE UAV fuselage structure is presented. The minimum strain energy with an optimization constraint of 20% of weight reduction is used in the objective function. Before the primary analysis, benchmark studies of topology optimization without considering orientations from previously published literature are performed. The convergence studies were taken to acquire the appropriate mesh size in the FEM technique, which utilized a four-noded shell element. The finite element analysis and optimization results showed that the structural design of the newly framed composite fuselage MALE UAV meets the structural strength requirements specified in the airworthiness standard STANAG 4671.
The Influence of Top Management’s Strategic Planning Capacity and Entrepreneurial Orientation on Corporate Entrepreneurship
Authors: Hung Kuo-Ting , Banerjee Somnath , Nordstrom Onnolee , Tangpong Chanchai , Li Yue , Li Jin 
Published: April 2023

Abstract
This study examines whether, and how, top management influences middle management’s support of corporate entrepreneurship activities. Specifically, the study explores the influence of top management characteristics, i.e. strategic planning capacity and entrepreneurial orientation, on manager’s decision to support innovation adoption. We report on the findings from a vignette study. Research participants included a group of 259 experienced business professionals: 148 from the United States and 111 from China. The results suggest that the alignment of strategic planning capacity and entrepreneurial orientation influences middle management’s support for corporate entrepreneurship in both cultural settings.
Youth, Quechua and neoliberalism in contemporary Perú
Authors: Zavala Virginia 
Published: April 2023

AbstractFramed within a critical and ethnographic approach to language policy, my study addresses the phenomenon of language commodification and the construction of neoliberal subjectivities in contemporary Perú. Specifically, I address a project of Quechua teaching in the city of Lima called Quechua para Todos, or Quechua for All, promoted by young Quechua activists developing interventions to change historically established imaginaries. Taking this project as a starting point, I analyze what is behind the extremely high demand these Quechua courses are having among youth in the capital city, where Quechua has been historically silenced. My argument is that a significant group of the young students from the courses have begun to integrate the Quechua language to the figure of the entrepreneurial subject for whom both personal and national branding is central. While speaking Quechua has historically indexed ‘indianness’ linked to backwardness, rurality, ancestrality and ignorance, it is now being associated with other linguistic and non-linguistic signs (such as being a professional and knowing English) to enregister a multicultural citizenship within a context of neoliberal economic growth and state policies of cultural branding. Although the demand to study Quechua in Lima is shifting the meanings and values of Quechua, at least within a domain of speakers, it may also be erasing ongoing processes of racialization of indigenous peoples in Peruvian society and fundamental gaps in access to education and economic resources.
Protected Interests under the Principles of European Tort Law (Art 2:102 PETL) – Preserving the Past for Shaping the Future
Authors: Infantino Marta 
Published: April 2023

Abstract
The paper examines gaps and potential amendments of art 2:102 of the Principles of European Tort Law (PETL) on the scope of protected interests in tort law, also in light of Prof Bénédict Winiger’s teachings on the history of tort law. To this end, the paper starts by highlighting the many strengths of art 2:102 PETL, focusing in particular on its ability to capture continental European identity and its inherent flexibility, making it resistant to time and compatible with multiple interpretations. It then delves into what may be undertaken to further strengthen art 2:102 PETL. Rather than modifying the provision, the paper suggests that what is most needed is further empirical research about the real world of European tort laws and a more transparent discussion about the functions that tort laws do, and could, perform.
Spin–orbit interactions in plasmonic crystals probed by site-selective cathodoluminescence spectroscopy
Authors: Taleb Masoud , Samadi Mohsen , Davoodi Fatemeh , Black Maximilian , Buhl Janek , Lüder Hannes , Gerken Martina , Talebi Nahid 
Published: April 2023

Abstract
The study of spin–orbit coupling (SOC) of light is crucial to explore the light–matter interactions in sub-wavelength structures. By designing a plasmonic lattice with chiral configuration that provides parallel angular momentum and spin components, one can trigger the strength of the SOC phenomena in photonic or plasmonic crystals. Herein, we explore the SOC in a plasmonic crystal, both theoretically and experimentally. Cathodoluminescence (CL) spectroscopy combined with the numerically calculated photonic band structure reveals an energy band splitting that is ascribed to the peculiar spin–orbit interaction of light in the proposed plasmonic crystal. Moreover, we exploit angle-resolved CL and dark-field polarimetry to demonstrate circular-polarization-dependent scattering of surface plasmon waves interacting with the plasmonic crystal. This further confirms that the scattering direction of a given polarization is determined by the transverse spin angular momentum inherently carried by the SP wave, which is in turn locked to the direction of SP propagation. We further propose an interaction Hamiltonian based on axion electrodynamics that underpins the degeneracy breaking of the surface plasmons due to the spin–orbit interaction of light. Our study gives insight into the design of novel plasmonic devices with polarization-dependent directionality of the Bloch plasmons. We expect spin–orbit interactions in plasmonics will find much more scientific interests and potential applications with the continuous development of nanofabrication methodologies and uncovering new aspects of spin–orbit interactions.
Synthesis and structural analysis of d-fructofuranosylated compounds for the analysis of GH172 difructose dianhydride I synthase/hydrolase
Authors: Ishiwata Akihiro , Kashima Toma , Kaieda Machika , Tanaka Katsunori , Fujita Kiyotaka , Fushinobu Shinya , Ito Yukishige 
Published: April 2023

Abstract

d-Arabinofuranosidases (Arafases) degrade the arabinan in the cell wall of acid-fast bacteria like Mycobacterium. Synthetic arabinan fragment probes could be used to investigate the function of d-Arafases, whose synthetic studies had been reported previously. The homologue of one of the arabinan-degrading enzymes, exo-α-d-Arafase, was identified as BBDE_2040 from Bifidobacterium dentium. BBDE_2040, which is a homologue of α-d-Arafase, was also observed to hydrolyze α-d-fructofuranosides (Fruf), whose linkage is found in food. In this paper, we present synthetic studies and structural analysis of the α-d-Araf and α-d-Fruf derivatives as substrates and products of the enzymatic reaction for a thorough examination of BBDE_2040. The results indicated that BBDE_2040 is a glycoside hydrolase (GH) family 172 difructose dianhydride I synthase/hydrolase and an anomer-retaining GH.
Chemistry of 2,2′-(diamino)azobenzene ligand: a brief review
Authors: Mandal Paritosh , Pratihar Jahar L. 
Published: April 2023

Abstract
In the last few decades, transition metal complexes incorporating various azo ligands have drawn much attention. A different group of researchers designed various multidentate azo ligands and explored the coordinating behavior with transition metals of such azo ligands. Transition metal chelates have a wide range of applications in synthetic chemistry. The ligand backbone containing both azo (–N=N–) and azomethine (–CH=N–) or imine (C=N–) groups have gained remarkable impetus for research in organometallic chemistry. The transition metal chelates incorporating azo-azomethine ligands are plentiful owing to their variant features with multiple coordination sites of the polydentate ligands. The versatile geometry of metal chelates and their potential applications in various fields of life has bestowed a high platform in coordination chemistry. The current review covers the synthetic strategies and coordination behavior of a potential azo ligand named 2,2′-bis(diamino)azobenzene and its related ligands with metal complexes of d-block elements. We have also scrutinized the applications of these ligands in synthetic chemistry and the azo-imine character of ligands in metal complexes.
Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration
Authors: Lawrence Jessica A. , Aguilar-Calvo Patricia , Ojeda-Juárez Daniel , Khuu Helen , Soldau Katrin , Pizzo Donald P. , Wang Jin , Malik Adela , Shay Timothy F. , Sullivan Erin E. , Aulston Brent , Song Seung Min , Callender Julia A. , Sanchez Henry , Geschwind Michael D. , Roy Subhojit , Rissman Robert A. , Trejo JoAnn , Tanaka Nobuyuki , Wu Chengbiao , Chen Xu , Patrick Gentry N. , Sigurdson Christina J. 
Published: April 2023

Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or for release in exosomes, yet how prions impact proteostatic pathways is unclear. We found that prion-affected human and mouse brain showed a marked reduction in Hrs and STAM1 (ESCRT-0), which route ubiquitinated membrane proteins from early endosomes into MVBs. To determine how the reduction in ESCRT-0 impacts prion conversion and cellular toxicityin vivo, we prion-challenged conditional knockout mice (male and female) havingHrsdeleted from neurons, astrocytes, or microglia. The neuronal, but not astrocytic or microglial, Hrs-depleted mice showed a shortened survival and an acceleration in synaptic derangements, including an accumulation of ubiquitinated proteins, deregulation of phosphorylated AMPA and metabotropic glutamate receptors, and profoundly altered synaptic structure, all of which occurred later in the prion-infected control mice. Finally, we found that neuronal Hrs (nHrs) depletion increased surface levels of the cellular prion protein, PrPC, which may contribute to the rapidly advancing disease through neurotoxic signaling. Taken together, the reduced Hrs in the prion-affected brain hampers ubiquitinated protein clearance at the synapse, exacerbates postsynaptic glutamate receptor deregulation, and accelerates neurodegeneration.SIGNIFICANCE STATEMENTPrion diseases are rapidly progressive neurodegenerative disorders characterized by prion aggregate spread through the central nervous system. Early disease features include ubiquitinated protein accumulation and synapse loss. Here, we investigate how prion aggregates alter ubiquitinated protein clearance pathways (ESCRT) in mouse and human prion-infected brain, discovering a marked reduction in Hrs. Using a prion-infection mouse model with neuronal Hrs (nHrs) depleted, we show that low neuronal Hrs is detrimental and markedly shortens survival time while accelerating synaptic derangements, including ubiquitinated protein accumulation, indicating that Hrs loss exacerbates prion disease progression. Additionally, Hrs depletion increases the surface distribution of prion protein (PrPC), linked to aggregate-induced neurotoxic signaling, suggesting that Hrs loss in prion disease accelerates disease through enhancing PrPC-mediated neurotoxic signaling.
Isolation of rice endophytic bacterial strain VY81 and study on its bioactive compound antagonizing the phytopathogen Dickeya zeae
Authors: Duy Toi Nguyen , Ngoc Mai Dinh Thi , Hieu Thu Nguyen Thi , Tien Dat Nguyen , Nhu Thao Nguyen Kim , Thuy Hang Dinh 
Published: April 2023

The bacterial communities performing endophytic lifestyle have been proven to possess a number of characteristics useful to host plants and thus are considered as “plant probiotics”. Many probiotic bacteria were reported for antagonism against different plant pathogens, including bacteria, fungi, and nematodes. The use of endophytic bacteria as biocontrol agents would have great potentials, allowing reducing the use of agrochemicals and thus support a sustainable agriculture.
In this study, endophytic bacteria isolated from rice plants of IR4625 cultivar from Long An province, Vietnam were used for screening strains that have antagonistic activity against Dickeya zeae (Dz), the bacterium causing foot rot disease. The rice plants had foot rot disease symptoms, i.e. dark-brown foot with odor smell typical for bacterial infection. Strain VY81 was isolated from a surface sterilized rice stem sample adjacent to the foot rot area. The crude extract of strain VY81 showed significant antagonistic activity against Dz, with the inhibition zone of 14,25 mm ± 1,06 in diameter. Strain VY81 produced the compound antagonizing Dz at maximal level after 48 h cultivated in TSB medium. The activity was found mainly in the culture broth, just a small part was found intracellularly. The bioactive compound antagonizing D. zeae produced by strain VY81 was purified by HPLC and analyzed by mass spectrometry and NMR spectroscopy. The compound was identified as a quinoline alkaloid, the chemical formula is C17H21ON with chemical name 2-(2-heptenyl)-3-methyl-4(1H)-quinolone. Comparative analyses of the 16S rDNA gene sequence revealed that strain VY81 belonged to the genus Burkholderia, most closely related to Burkholderia cepacia (99,77% sequence homology). The 16S rDNA sequence of strain VY81 was deposited at GenBank under accession number MW056196. Strain VY81 and its quinolone compound would have application potential for development of biocontrol product against the foot rot disease caused by Dickeya zeae.