bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of sentinel lymph node biopsy in elderly patients with breast cancer – 10-year experience from a Swiss university hospital
Authors: Heidinger Martin , Maggi Nadia , Dutilh Gilles , Mueller Madleina , Eller Ruth S. , Loesch Julie M. , Schwab Fabienne D. , Kurzeder Christian , Weber Walter P. 
Published: June 2023

Abstract
Background
The Choosing Wisely initiative recommended the omission of routine sentinel lymph node biopsy (SLNB) in patients ≥ 70 years of age, with clinically node-negative, early stage, hormone receptor (HR) positive and human epidermal growth factor receptor 2 (Her2) negative breast cancer in August 2016. Here, we assess the adherence to this recommendation in a Swiss university hospital.

Methods
We conducted a retrospective single center cohort study from a prospectively maintained database. Patients ≥ 18 years of age with node-negative breast cancer were treated between 05/2011 and 03/2022. The primary outcome was the percentage of patients in the Choosing Wisely target group who underwent SLNB before and after the initiative went live. Statistical significance was tested using chi-squared test for categorical and Wilcoxon rank-sum tests for continuous variables.

Results
In total, 586 patients met the inclusion criteria with a median follow-up of 2.7 years. Of these, 163 were ≥ 70 years of age and 79 were eligible for treatment according to the Choosing Wisely recommendations. There was a trend toward a higher rate of SLNB (92.7% vs. 75.0%, p = 0.07) after the Choosing Wisely recommendations were published. In patients ≥ 70 years with invasive disease, fewer received adjuvant radiotherapy after omission of SLNB (6.2% vs. 64.0%, p < 0.001), without differences concerning adjuvant systemic therapy. Both short-term and long-term complication rates after SLNB were low, without differences between elderly patients and those < 70 years.

Conclusions
Choosing Wisely recommendations did not result in a decreased use of SLNB in the elderly at a Swiss university hospital.
Paediatric Cogan´s syndrome - review of literature, case report and practical approach to diagnosis and management
Authors: Rücklová Kristina , von Kalle Thekla , Koitschev Assen , Gekeler Katrin , Scheltdorf Miriam , Heinkele Anita , Blankenburg Friederike , Kötter Ina , Hospach Anton 
Published: June 2023

Abstract
Background
Cogan´s syndrome is a rare, presumed autoimmune vasculitis of various vessels characterized by interstitial keratitis and vestibular impairment accompanied by sensorineural hearing loss. Due to the rarity of Cogan´s syndrome in children, therapeutic decision making may be challenging. Therefore, a literature search was performed to collect all published paediatric Cogan´s syndrome cases with their clinical characteristics, disease course, treatment modalities used and their outcome. The cohort was supplemented with our own patient.

Main text
Altogether, 55 paediatric Cogan´s syndrome patients aged median 12 years have been reported so far. These were identified in PubMed with the keywords “Cogan´s syndrome” and “children” or “childhood”. All patients suffered from inflammatory ocular and vestibulo-auditory symptoms. In addition, 32/55 (58%) manifested systemic symptoms with musculoskeletal involvement being the most common with a prevalence of 45%, followed by neurological and skin manifestations. Aortitis was detected in 9/55 (16%). Regarding prognosis, remission in ocular symptoms was attained in 69%, whereas only 32% achieved a significant improvement in auditory function. Mortality was 2/55. Our patient was an 8 year old girl who presented with bilateral uveitis and a history of long standing hearing deficit. She also complained of intermittent vertigo, subfebrile temperatures, abdominal pain with diarrhoea, fatigue and recurrent epistaxis. The diagnosis was supported by bilateral labyrinthitis seen on contrast-enhanced magnetic resonance imaging. Treatment with topical and systemic steroids was started immediately. As the effect on auditory function was only transient, infliximab was added early in the disease course. This led to a remission of ocular and systemic symptoms and a normalization of hearing in the right ear. Her left ear remained deaf and the girl is currently evaluated for a unilateral cochlear implantation.

Conclusions
This study presents an analysis of the largest cohort of paediatric Cogan´s syndrome patients. Based on the collected data, the first practical guide to a diagnostic work-up and treatment in children with Cogan´s syndrome is provided.
Trajectories of children and adolescents attending a psychiatric emergency unit during the COVID-19 confinements: 2020–2022 longitudinal study
Authors: Adrados-Pérez Marina , Llorca-Bofí Vicent , Laín María Mur , Porcar Carla Albert , Nicolau-Subires Eugènia , Ibarra-Pertusa Lucía , Jiménez-Mayoral Andrea , Buil-Reiné Esther , Budny Filip , Resa-Pérez Belén , Velásquez-Acebey Vanessa Gladys , Arenas-Pijoan Laura , Irigoyen-Otiñano María , López-Castroman Jorge 
Published: June 2023

Abstract
Introduction
The prevalence of psychiatric disorders has not shifted widely through the COVID pandemic, except for some specific groups such as young people or women. Our objective is to examine prospectively the evolution of children and adolescents who consulted in a psychiatric emergency service during the COVID-19 confinements.

Method
We collected prospective clinical information about 296 young people under 18 who visited a tertiary hospital for psychiatric reasons during the confinement periods in Spain. Clinical diagnoses, suicide attempts, hospital admissions, and pharmacological prescriptions were extracted from electronic health records through 2020, 2021, and 2022. Features of those who maintained psychiatric care and those who did not were compared.

Results
Three out of four children and adolescents who visited the psychiatric emergency department during the confinements continued psychiatric care at the end of 2022. Those who did not showed better premorbid adjustment at baseline. During follow-up, diagnoses of neurodevelopmental disorders and eating disorders, as well as the dosage of psychotropic drug prescriptions, increased. The diagnoses of major depressive disorder and eating disorder at baseline were associated with attempting suicide during follow-up. Patients with internalizing symptoms were admitted earlier than those with externalizing symptoms but no differences were found in terms of suicide attempts.

Conclusions
The continuity of psychiatric care after an initial emergency visit during the confinements implied greater clinical severity, as reflected by changes in clinical diagnoses and pharmacological regimens. Emergent symptoms of depression or eating disorders after social distancing or isolation could predict subsequent suicidal behavior in young populations.
Advances in the application of Mxene nanoparticles in wound healing
Authors: Liang Chengzhi , He Jing , Cao Yuan , Liu Guoming , Zhang Chengdong , Qi Zhiping , Fu Chuan , Hu Yanling 
Published: June 2023

AbstractSkin is the largest organ of the human body. It plays a vital role as the body’s first barrier: stopping chemical, radiological damage and microbial invasion. The importance of skin to the human body can never be overstated. Delayed wound healing after a skin injury has become a huge challenge in healthcare. In some situations, this can have very serious and even life-threatening effects on people’s health. Various wound dressings have been developed to promote quicker wound healing, including hydrogels, gelatin sponges, films, and bandages, all work to prevent the invasion of microbial pathogens. Some of them are also packed with bioactive agents, such as antibiotics, nanoparticles, and growth factors, that help to improve the performance of the dressing it is added to. Recently, bioactive nanoparticles as the bioactive agent have become widely used in wound dressings. Among these, functional inorganic nanoparticles are favored due to their ability to effectively improve the tissue-repairing properties of biomaterials. MXene nanoparticles have attracted the interest of scholars due to their unique properties of electrical conductivity, hydrophilicity, antibacterial properties, and biocompatibility. The potential for its application is very promising as an effective functional component of wound dressings. In this paper, we will review MXene nanoparticles in skin injury repair, particularly its synthesis method, functional properties, biocompatibility, and application.
Financial outcomes after pediatric critical illness among commercially insured families
Authors: Carlton Erin F. , Moniz Michelle H. , Scott John W. , Prescott Hallie C. , Becker Nora V. 
Published: June 2023

AbstractCritical illness results in subjective financial distress for families, but little is known about objective caregiver finances after a child’s pediatric intensive care unit (PICU) hospitalization. Using statewide commercial insurance claims linked to cross-sectional commercial credit data, we identified caregivers of children with PICU hospitalizations in January–June 2020 and January–June 2021. Credit data included delinquent debt, debt in collections (medical and non-medical), low credit score (< 660), and a composite of any debt or poor credit and were measured in January 2021 for all caregivers. For the 2020 cohort (“post-PICU”), credit outcomes in January 2021 were measured at least 6 months following PICU hospitalization and reflect financial status after the hospitalization. For the 2021 cohort (comparison), financial outcomes were measured prior to their child’s PICU hospitalization and therefore reflect pre-hospitalization financial status. We identified 2032 caregivers, 1017 post-PICU caregivers and 1015 comparison cohort caregivers, of which 1016 and 1014 were matched to credit data, respectively. Post-PICU caregivers had higher adjusted odds of having any delinquent debt [aOR 1.25; 95%CI 1.02–1.53; p = 0.03] and having a low credit score [aOR 1.29; 95%CI 1.06–1.58; p = 0.01]. However, there was no difference in the amount of delinquent debt or debt in collections among those with nonzero debt. Overall, 39.5% and 36.5% of post-PICU and comparator caregivers, respectively, had delinquent debt, debt in collections or poor credit. Many caregivers of critically ill children have financial debt or poor credit during hospitalization and post-discharge. However, caregivers may be at higher risk for poor financial status following their child’s critical illness.
Prevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study
Authors: Andrei Stefan , Bahr Pierre-Alain , Nguyen Maxime , Bouhemad Belaid , Guinot Pierre-Grégoire 
Published: June 2023

Abstract
Background
The importance of assessing venous congestion in ICU patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool. The Venous Excess Ultrasound Grading System (VExUS), based on a semi-quantitative combined ultrasound assessment, has been associated with acute kidney injury (AKI) in cardiac ICU patients. The objectives of this study were to assess the prevalence of congestion using VExUS in general ICU patients, and to evaluate the association between VExUS, AKI and death.

Methods
This prospective, observational study included adult patients within 24 h of ICU admission. VExUS and hemodynamic parameters were measured four times during the ICU stay: within 24 h of ICU admission, after day 1 (between 24 and 48 h), after day 2 (between 48 and 72 h), and last day of ICU stay. The prevalence of AKI during the first week in ICU and 28-day mortality were assessed.

Results
Among the 145 patients included, the percentage of patients with a VExUS score of 2 (moderate congestion) and 3 (severe congestion) was 16% and 6%, respectively. The prevalence did not change over the study period. There was no significant association between admission VExUS scores and AKI (p = 0.136) or 28-day mortality (p = 0.594). Admission VExUS ≥ 2 was not associated with AKI (OR 0.499, CI95% 0.21–1.17, p = 0.109) nor 28-day mortality (OR 0.75, CI95% 0.2–2.8, p = 0.669). The results were similar for VExUS scores measured at day 1 and day 2.

Conclusions
In general ICU cohort the prevalence of moderate to severe venous congestion was low. Early assessment of systemic venous congestion using VExUS scores was not associated with the development of AKI or with 28-day mortality.
Evaluation of renal values during treatment for heartworm disease in 27 client-owned dogs
Authors: Vetter C. Autumn M. , Meindl Alison G. , Lourenço Bianca N. , Coyne Michael , Drake Corie , Murphy Rachel , Roth Ira G. , Moorhead Andrew R. 
Published: June 2023

Abstract
Background
Canine heartworm disease (CHD) caused by Dirofilaria immitis remains a common preventable disease with increasing incidence in some parts of the USA. The treatment guidelines of the American Heartworm Society (AHS) currently recommend monthly macrocyclic lactone administration, 28 days of doxycycline given orally every 12 h and three injections of melarsomine dihydrochloride (1 injection on day 2 of treatment followed 30 days later by 2 injections 24 h apart). Minocycline has also been utilized when doxycycline is unavailable. The systemic effects of CHD, which particularly impact cardiac and renal function, have been described, with infected dogs often experiencing renal damage characterized by an increase in serum concentrations of renal biomarkers. Although the AHS treatment protocol for CHD has been shown to be safe and effective in most cases, the potential for complications remains. No study as of yet has evaluated changes in symmetric dimethylarginine (SDMA), a sensitive marker of renal function, during treatment for CHD. The purpose of the present study was to evaluate renal function in dogs by measuring serum creatinine and SDMA concentrations during the adulticide treatment period.

Methods
Serum creatinine and SDMA concentrations were measured in 27 client-owned dogs affected by CHD at the following time points: prior to starting doxycycline or minocycline therapy (baseline), during doxycycline or minocycline therapy (interim), at the time of the first dose of melarsomine (first dose), at the time of the second dose of melarsomine (second dose) and at the dog’s follow-up visit after treatment, occurring between 1 and 6 months after completion of therapy (post-treatment). Concentrations of creatinine and SDMA were compared between time points using a mixed effects linear model.

Results
Mean SDMA concentrations following the second dose of melarsomine were significantly lower (−1.80 ug/dL, t-test, df = 99.067, t = −2.694, P-Value = 0.00829) than baseline concentrations. There were no other statistically significant differences in the concentration of either biomarker between the baseline and the other time points in CHD dogs undergoing treatment.

Conclusions
The results suggest that the current AHS protocol may not have a substantial impact on renal function.

Graphical Abstract
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
Authors: Berumen Jaime , Orozco Lorena , Gallardo-Rincón Héctor , Rivas Fernando , Barrera Elizabeth , Benuto Rosa E. , García-Ortiz Humberto , Marin-Medina Melissa , Juárez-Torres Eligia , Alvarado-Silva Anabel , Ramos-Martinez Espiridión , MartÍnez-Juárez Luis Alberto , Lomelín-Gascón Julieta , Montoya Alejandra , Ortega-Montiel Janinne , Alvarez-Hernández Diego-Abelardo , Larriva-Shad Jorge , Tapia-Conyer Roberto 
Published: June 2023

AbstractBackgroundThis study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development.MethodsIn this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, ≤ 45 years; late, ≥ 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (R2) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist–hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models.ResultsT2D-related genes influenced T2D development most in males who were diagnosed early (R2 = 23.5%; females,R2 = 13.5%; males and females diagnosed late,R2 = 11.9% andR2 = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% ofR2) while peripheral insulin resistance-associated genes were more influential in females (52.3% ofR2). With a late diagnosis, insulin production-related genes from chromosome region 11p15.5 notably influenced males while peripheral insulin resistance and genes associated with inflammation and other processes notably influenced females. Influence of parental history was higher among those diagnosed early (males, 19.9%; females, 17.5%) versus late (males, 6.4%; females, 5,3%). Unilateral maternal T2D history was more influential than paternal T2D history. BMI influenced T2D development for all, while WHR exclusively influenced males.ConclusionsThe influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females.
A relict Triassic brittle star (Echinodermata, Ophiuroidea) in Lower Jurassic strata of Asturias, north-west Spain
Authors: Thuy Ben , Piñuela Laura , García-Ramos José Carlos 
Published: June 2023

AbstractOphiuroids, also known as brittle stars, are an important component of modern marine benthos, yet their fossil record is still poorly understood. Here, we describe new finds of ophiuroids from the upper Sinemurian (Lower Jurassic) of Asturias, north-west Spain. The material consists of several articulated specimens that show all relevant anatomical details to allow for an exhaustive description of a new species, Arenorbis santameraensis sp. nov., which adds a Jurassic member to the genus Arenorbis previously known exclusively from the Middle Triassic of central Europe. We demonstrate that Arenorbis has characters that are typically found in the suborder Ophiodermatina. The new Jurassic record of Arenorbis shows remarkable parallels with its Middle Triassic equivalents in terms of sedimentological and taphonomic context, suggesting niche conservatism in this genus. In contrast to its wide geographical distribution during the Middle Triassic, the new species is currently only known from a restricted area, which suggests that it represents a Jurassic relict of a formerly widespread Triassic lineage.ZooBank LSID: urn:lsid:zoobank.org:pub:D253BD9D-53C3-44BA-884B-15BA1F7876D3
Characterization of phytochemical profile of rhizome of artificial cultured Polygonatum sibiricum with multiple rhizome buds
Authors: Cheng Weiqing , Pan Zhibin , Zheng Hanjing , Luo Gelian , Liu Zhibin , Xu Suli , Lin Junhan 
Published: June 2023

AbstractRhizome of Polygonatum sibiricum is both a renowned traditional Chinese remedy and a commonly consumed delicacy. Due to the escalating demand and excessive overexploitation, there has been a growing interest in the artificial cultivation of this plant in recent years. To assess the therapeutic benefits of artificially cultivated P. sibiricum, it is crucial to identify and classify its phytochemical components, which are the primary bioactive compounds found in its rhizome. In this study, the phytochemical profile of an artificially cultivated P. sibiricum rhizomes with multiple rhizome buds (ACM) was characterized by using untargeted UHPLC-Q-Orbitrap-MS based approach. In addition, two-wild-types P. sibiricum rhizomes, namely the wild-type with multiple rhizome buds (WTM) and the wild-type with single rhizome bud (WTS), were used for comparison. A total of 183 phytochemicals, including 20 alkaloids, 48 flavonoids, 33 phenolic acids, and 82 terpenoids, were tentatively identified. Generally, the phytochemical profile of ACM was comparable to that of WTM and WTS. In specific, most of the identified alkaloids and phenolic acids, and approximately half of the identified terpenoids, were not significantly different. Notably, several phytochemicals with potent therapeutic properties, such as epiberberine, laetanine, sinapic acid, curcumenol, were present in ACM. Additionally, artificial cultivation increased the abundance of geniposide and naringenin, which have been linked to cardioprotective effects. These findings provide valuable insights for the future utilization of artificially cultivated P. sibiricum.
Characterisation of food governance for alternative and sustainable food systems: a systematic review
Authors: Oñederra-Aramendi Aintzira , Begiristain-Zubillaga Mirene , Cuellar-Padilla Mamen 
Published: June 2023

AbstractDespite the various studies on food governance structured around alternative food systems (AFS), analysis of the essential characteristics of it which facilitate the sustainability of the food system (FS) is still incipient. This study aims to clarify the debate on the role of governance in sustainability of the FS by way of the following two objectives: (i) to characterise the analytical approach of the literature in the processes of structuring of food governance related to AFS, and (ii) to reflect qualitatively on the essential factors to be considered which ensure sustainable processes and trajectories of the AFS. The research methodology is based on a systematic review of the literature in order to define the approaches identified in the relevant studies in their analysis of the food governance process. From the results, a conceptual framework is proposed that determines the strategies related to food governance which can help meet the challenges of the AFS. A multi-actor and multilevel governance is identified that takes into account both structural and variable aspects linked to the interdependent relationships that are involved in the construction processes of the alternative food networks (AFN). We conclude our study by identifying certain gaps in the knowledge as well as new lines of study that we deem necessary in order to consolidate the AFS from a vision of sustainability.