bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological Responses to Organizational Stressors Among Police Managers
Authors: Nota Paula M. Di , Scott Sarah C. , Huhta Juha-Matti , Gustafsberg Harri , Andersen Judith P. 
Published: August 2023

Abstract
Police officers demonstrate increased risk of physical and mental health conditions due to repeated and prolonged exposure to stressful occupational conditions. Occupational stress is broken into two types: operational stress, related to the content of field duties (e.g., physical demands); and organizational stress, related to cultural and structural contexts (e.g., interpersonal relationships). Applied police research focuses on physiological activation in operational tasks as a mechanism explaining health risk and non-optimal performance outcomes. However, recent survey-based studies indicate numerous organizational stressors associated with self-reported mental health symptoms. The question of whether organizational stressors elicit significant physiological activity remains unknown. The current proof-of-concept field study tests the hypothesis that police managers will display significant physiological reactivity before, during, and after engaging in reality-based scenarios representative of stressful police management tasks developed from evidence-based pedagogical approaches. A sample of 25 training police managers (7 female, M = 16 +/- 5.3 years of experience) completed 5 reality-based scenarios, including resolving a heated conflict between colleagues, delivering negative feedback to a subordinate, and critical incident command. Significant increases in heart rate relative to rest were observed during all tasks, and in anticipation of several tasks. Greater increases in reactive heart rate were associated with longer recovery times. Sex differences and relationships between objective biological and subjective psychological measures of stress are discussed. The current findings demonstrate significant physiological responses to organizational stressors similar to levels observed during operational tasks, despite the absence of physical or aerobic exertion. Implications for police health and training are discussed.
Strict intuitionistic fuzzy distance/similarity measures based onJensen-Shannon divergence
Authors: Wu Xinxing , Zhu Zhiyi , Garg Harish , Chen Guanrong , Liu Peide 
Published: August 2023

Abstract
Being a pair of dual concepts, the normalized distance and similarity measures are important tools fordecision-making and pattern recognition under an intuitionistic fuzzy set framework. A good normalizeddistance measure should ensure that its dual similarity measure satisfies the axiomatic definition in orderto be more effective for problems. In this paper, we first construct some counterexamples to illustrate thattwo existing measures do not meet the axiomatic definition of intuitionistic fuzzy similarity measures.We then show that (1) these two measures cannot effectively distinguish some intuitionistic fuzzy values(IFVs), which can be directly judged by our intuition; (2) except for the endpoints, there exist infinitelymany pairs of IFVs, where the maximum distance 1 can be achieved under these two distances, leading tocounter-intuitive results. To overcome these drawbacks, we introduce the concept of strict intuitionisticfuzzy distance measure (SIFDisM) and strict intuitionistic fuzzy similarity measure (SIFSimM), andpropose an improved intuitionistic fuzzy distance measure based on Jensen-Shannon divergence. Weprove that (1) it is a SIFDisM; (2) its dual similarity measure is a SIFSimM; (3) its induced entropyis an intuitionistic fuzzy entropy. Comparative analysis and numerical examples demonstrate that ourproposed distance measure is completely superior to the existing ones.
Unveiling The Role of lncRNA NRON and NFATc3 In Type 2 Diabetes Mellitus: A Molecular Insight for Disease Pathogenesis and Biomarker Discovery
Authors: Zebardast Diba , Salehi Zivar , Zaersabet Mona , Sojoudi Kiana , Mashayekhi Farhad , Motamed Behrang 
Published: August 2023

Abstract
Background
Long non-coding RNAs (lncRNAs) are key factors in the progression of many metabolic diseases. This study aimed to investigate the role of long non-coding RNA repressor of the nuclear factor of activated T cells (lncRNA NRON) and nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) in type-2 diabetes mellitus (T2DM).
Methods and Results
The expression patterns of NRON and NFATc3 were measured using quantitative real-time PCR and western blotting. Network analysis and gene enrichment analysis were carried out using bioinformatic tools and the Cytoscape platform. The results showed that NRON was upregulated in T2DM patients, while NFATc3 gene and protein accounted for a lower expression (p < 0.05). Bioinformatics analysis displayed that these biomarkers play key roles in multiple mechanisms and pathways linked to the development of T2DM.
Conclusions
lncRNA NRON and NFATc3 can act as potential biomarkers for the diagnosis and prognosis of T2DM.
Decreased gene expression of common γ-chain receptor (CD132) in tissues of Crohn’s disease patients
Authors: JC Andreu-Ballester , Hurtado-Marcos Carolina , García-Ballesteros Carlos , Pérez-Griera Jaime , Izquierdo Fernando , Ollero Dolores , Gil-Borras Rafael , Llombart_Cussac Antonio , Lopez_Chulia Francisca , Cuéllar Carmen 
Published: August 2023

Abstract
Background.
A deficiency of γδ T cells has been described in Crohn's disease (CD). Our goal was to analyze the gene expression of IL-7 and its receptors in tissues of patients with CD.
Methods
We studied the peripheral blood of 80 patients with Crohn's disease, comparing them with a group of 80 healthy subjects. The number and apoptosis of αβ and γδ T cells in peripheral blood and the proportion of αβ and γδ T cells in intestinal tissues of CD patients (n = 25) were studied. IL-7 gene expression, IL-7 protein, common γ-chain receptor (CD132), receptor α (CD127) and caspase 3 in tissues were analyzed by qPCR. Serum IL-7 levels were analyzed.
Results
An increase in apoptosis of CD56 + αβ and γδ T cells in peripheral blood was observed, beside IL-7 gene expression and IL-7 protein in tissues of these patients were increased. The titers of caspase 3 in tissues were low. The number of γδ T cells decreased, and was directly related to IL-7 levels in peripheral blood. The expression of common γ-chain receptor (CD132) is greatly decreased in the tissues of Crohn's disease patients.
Conclusion
There may be a cause-effect relationship between the lower gene expression of the common receptor of the γ chain (CD132) and this immunodeficiency.
WoS-CoMS : Work Stealing-based Congestion Management Scheme for SDN programmable networks
Authors: Yankam Yannick Florian , Tchendji Vianney Kengne , Myoupo Jean Frédéric 
Published: August 2023

Abstract
In recent years, the SDN (Software-Defined Networking) paradigm emerged as an easy way to manage large-scale network infrastructures through programmability brought out and its control plane/data plane decoupling logic. This enables infrastructure and service providers to have a global view of the network and track traffic flows from a remote controller. However, congestion control remains a concern due to the evolution of increasingly complex and resource-intensive user requirements (virtual reality, metaverse, Internet of Things (IoT), Artificial Intelligence (AI), Cloud, ...) on network infrastructures. This server state leads to high latency in request processing and data loss. This paper proposes in such controller-supervised environment, a congestion management scheme within network service servers to maintain acceptable quality of service. The strategy relies on work stealing to ensure better workload balancing. Simulations show that the proposed solution can reduce congestion load into the servers by up to 22%, depending on request grain size, within a shorter latency than other works in the literature. Moreover, the proposed solution allows stolen tasks to be completed within a shorter timeframe.
Novel 4-nitroimidazole analogues: Synthesis, in vitro biological evaluation, in silico studies and molecular dynamics simulation
Authors: Al-Soud Yaseen A. , Al-Sawakhnah Sondos O. , Al-Qawasmeh Raed A. , Al-Masoudi Najim A. , Al-Ahmad Ala’a H. , Al-Maliki Lamia , Geelen Lasse , Kalscheuer Rainer , Saeed Bahjat A. , Shtaiwi Amneh , Stark Holger 
Published: August 2023

Abstract

A new series of 4-nitroimidazole bearing substituted aryl piperazines 7-16, tetrazole 17 and 1,3,4-thiadiazole 18 derivatives was designed and synthesized. All derivatives were screened for their anticancer activity against eight diverse human cancer cell lines (Capan-1, HCT-116, LN229, NCI-H460, DND-41, HL-60, K562 and Z138). Compound 17 proved the most potent compound of the series inhibiting proliferation of most of the selected human cancer cell lines with IC50 values in the low micromolar range. In addition, compound 11 exhibited IC50 values ranging 8.60 to 64.0 μM against a selection of cancer cell lines, whereas compound 18 showed IC50 values varying between 8.25 and 43.55 μM against all the selected cancer cell lines, whereas. These findings suggest that derivative 17 can potentially be a new lead compound for further development of novel antiproliferative agents. Additionally, compounds 17-18 were assessed for their antibacterial and antituberculosis activity, where derivatives 17 and 18 were the most potent compounds of the series against both Staphylococcus aureus strain Wichita and a methicillin resistant strain of Staphylococcus aureus (MRSA), as well as against M. tuberculosis strain mc26230. The antiviral activity of compounds 7-18 was also evaluated but no activity was found against the selected viruses. The docking studies were conducted to predict the interaction of derivative 17 with putative protein targets in acute myeloid leukemia, specifically Fms-like tyrosine kinase-3 (FLT3). The results showed a docking score of -8.132 kcal/mol-1, indicating a strong binding affinity. Additionally, it was observed that derivative 17 exhibited favorable hydrophobic interactions with the active site of the tyrosine kinase-3. Furthermore, the analysis of the 200 ns molecular dynamics simulation results based on the best-docked complexes 17 and 18 with tyrosine kinase-3 receptor demonstrates stable interactions, and the complexes undergo the same conformational fluctuations. The average of the calculated binding free energy of complex 17 and 18 are -184.6 kJ/mol and -160.2 kJ/mol, respectively, and the result demonstrated that complex 17 promoted higher stability than complex 18 to the tyrosine kinase-3.
Use of Continuous Glucose Monitoring in Insulin-Treated Older Adults with Type 2 Diabetes
Authors: Leite Silmara A O , Silva Michael P , Lavalle Ana C R , Bertogy Maria C V , Bastos Murilo , Kuklik Suelen C V , Umpierrez Guillermo 
Published: August 2023

Abstract
Background
Few studies have reported on the adherence and efficacy of continuous glucose monitoring (CGM) in improving diabetes management in insulin-treated older adults with type 2 diabetes mellitus (T2DM).
Methods
Prospective observational cohort study using FreeStyle Libre Flash CGM in insulin-treated adults > 65 years with T2DM and HbA1c between 7% and 9%. Participants wore the CGM during a 6-weeks study period. The primary outcome was time in range (TIR) between 70–180 mg/dl. Secondary outcomes included time below range (TBR), glycemic variability (GV), adherence, and use of glucose data for self-insulin adjustment.
Results
A total of 66 participants completed the six weeks of CGM (age 72·8 ± 5·3 years; BMI 27·8 ± 3·6 kg/m2), HbA1c: 8·0 ± 0·6%, with an overall sensor utilization of 93·1 ± 6·0%. Compared to baseline, we observed stability in TIR (67% vs. 70%, p = 0.190, and a significant reduction in glucose variability (34·9 ± 7·2 vs. 32·9 ± 6·8, p = < 0.001) and in TBR (4% vs. 2%, p = 0.008).
Conclusion
The FreeStyle Libre Flash CGM was well accepted by older adults with T2DM and allowed participants to make therapy decisions to improve TIR and reduce TBR and glycemic variability. This real-world study indicates that CGM is safe and effective in improving glycemic control and should be offered to insulin-treated older adults with T2DM.
Fibrin Glue Closure Versus Lateralising Flap Procedures in the Management of Pilonidal Sinus Disease in Adolescents: A 14-year Cohort Study
Authors: Giles William , Murthi Govind , Lindley Richard 
Published: August 2023

Abstract
Introduction
Pilonidal sinus disease (PSD) arises in the hair follicles of the gluteal cleft with many cases occurring during adolescence. Early studies of pit excision with fibrin glue closure (PEF), a minimally invasive procedure for the management of chronic PSD, suggest it is safe and effective with similar results to traditional lateralising flap procedures (LFP), without the need for extensive tissue excision and associated complications. However, these studies lack large sample sizes and prolonged follow-up.
Methodology
All children undergoing primary operative procedures for chronic PSD from May 2009 to February 2023 received either a PEF or a LFP. Recurrence and complications rates alongside their demographic and disease severity data were compared using statistical and Kaplan-Meier analyses.
Results
Seventy-eight children had 33 primary PEF and 45 primary LFP procedures with a median follow-up of 2.21 and 2.52 years respectively. Demographic and disease severity indicators were similar between groups (p>0.05).
The overall recurrence rate in each cohort was 3% for PEF and 11% for LFP respectively (p = 0.2346). The all-cause repeat intervention rate was 12% and 49% in the PEF and LFP cohorts respectively (p = 0.0007). Kaplan-Meier analysis showed a reduction in the requirement of re-operation in the PEF cohort (p = 0.0340).
Operative time was significantly decreased in the PEF cohort compared to the LFP cohort (p <0.0001). Wound dehiscence was significantly decreased in the PEF cohort compared to the LFP cohort (3% vs 31%; p = 0.0026).
Conclusion
This 14-year study is the largest paediatric-focussed cohort utilising PEF to manage PSD and demonstrated clinically relevant decreases in symptom recurrence alongside significantly decreased rates of complications and further surgical intervention compared to traditional LFP techniques. We conclude that PEF is a viable minimally invasive technique in the management of paediatric PSD.
Muscone Inhibits Angiotensin II–induced Cardiac Hypertrophy Through the STAT3, MAPK and TGF-β/SMAD Signaling Pathways
Authors: Liu Yi-jiang , Xu Jia-jia , Yang Cui , Li Yan-ling , Chen Min-wei , Liu Shi-xiao , Zheng Xiang-hui , Luo Ping , Li Rui , Xiao Di , Shan Zhong-gui 
Published: August 2023

Abstract
Context: Muscone is a chemical monomer derived from musk. Although many studies have confirmed the cardioprotective effects of muscone, the effects of muscone on cardiac hypertrophy and its potential mechanisms are unclear.
Objective: The aim of the present study was to investigate the effect of muscone on angiotensin (Ang) II-induced cardiachypertrophy.
Materials and methods: The viability of H9C2 and AC16 cells was assessed by CCK8 assay. The expression of proteins was evaluated by RT-PCR and Western blot analysis. Echocardiographic paraments were obtained by a Visual sonics high resolution Vevo 2100 system. H&E staining was used to assess myocardial structural changes. Masson trichrome staining was used to assess degree of fibrosis. Serum Biochemical Indexes were detected by automatic chemistry analyzer.
Results: In the present study, we found for the first time that muscone exerted inhibitory effects on Ang II-induced cardiac hypertrophy and cardiac injury in mice. Secondly, we showed that muscone attenuated cardiac injury by reducing the secretion of proinflammatory cytokines and promoting the secretion of anti-inflammatory cytokines. Moreover, we found that muscone exerted cardioprotective effects by inhibiting phosphorylation of key proteins in the STAT3, MAPK and TGF-β/SMAD pathways. In addition, the in vivo and in vitro validation found no significant toxicity or side effects of muscone on normal cells and organs.
Discussion and conclusions: Muscone could attenuate Ang II-induced cardiac hypertrophy, in part, by inhibiting the STAT3, MAPK, and TGF-β/SMAD signaling pathways.
Investigation on the volatiles and aromatic characteristic of Raw Pu-erh tea with different storage durations by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry and odor activity value analysis
Authors: Guo Jie , Yu Zhihao , Liu Meiyan , Guan Mengdi , Shi Aiyun , Hu Yongdan , Li Siyu , Ren Dabing , Yi Lunzhao 
Published: August 2023

Abstract
Volatile constituents are critical to the flavor of tea, but the changes of them in Raw Pu-erh tea (RAPT) during storage have not been clearly understood. This work aimed to investigate the volatile composition and their changes of RAPT at various storage durations. The volatile profile of RAPT was determined using headspace solid-phase microextraction in combination gas chromatography-mass spectrometry. A total of 130 volatile compounds were identified in RAPT samples, and 64 of them were shared by all samples. The aroma attributes of RAPT over a storage period ranging from 0 to 10 years were assessed through the integration of odor activity value, aroma characteristic influence value and multivariate statistical. The results revealed that RAPT highlighted a distinct floral and fruity aroma profile after storage for approximately 3 - 4 years. Furthermore, a notable shift in aroma was observed after 5 and 10 years of storage. According to the odor activity value (≥ 100), eight volatile compounds were revealed as the key compounds to the aroma of RAPT during storage. These compounds include linalool, α-terpineol, geraniol, trans-𝛽-ionone, α-ionone, (E,E)-2,4-heptadienal, 1-octanol, and octanal. The findings of this study offer a scientific foundation and valuable insights for understanding the quality of RAPT during storage.
On the Thermal Hysteresis Behavior of Encapsulated Latent Heat Storage with Various Geometry
Authors: Ali Farooq Hassan , Hamzah Hameed Kadhem , Alhattab Tahssen , Hayder Abdul-Mohsin , Ajarostaghi Seyed 
Published: August 2023

Abstract
In this work, thermal hysteresis of PCM inside different encapsulated configuration (circle, triangle and square) during melting and solidification processes are investigated numerically. Charging and discharging of a latent heat storage during unsteady complex phenomena was simulated numerically using finite element method. The results indicate that time elapsed was minimum for triangular encapsulated configuration and maximum time for circular encapsulated configuration for both melting and solidification process. The time of thermal hysteresis of melting and solidification process decreased with the increasing Ryleigh number for all encapsulated configuration. Circular encapsulated configuration having higher latent heat storage than triangular and square encapsulated configurations, while circular encapsulated configuration has minimum.
Kaumātua (elders’) insights into indigenous Māori approaches to understanding and managing pain: A qualitative Māori-centred study
Authors: Morunga Eva , Bean Debbie , Tuahine Korina , Hohepa Karlee , Lewis Gwyn , Ripia Donald , Terry Gareth 
Published: August 2023

Abstract

Background:
Chronic pain/mamae is a major public health problem worldwide, and disproportionately affects indigenous populations impacted by colonisation. In Aotearoa New Zealand, indigenous Māori experience a greater burden of chronic pain than non-Maori. However, pain services based on Western models are unlikely to meet the needs of indigenous peoples well. Little is published about traditional Māori views of, or approaches to, managing mamae/pain, knowledge that is traditionally held by kaumātua/elders. This study therefore aimed to understand kaumātua (Māori elder) views on the effects of pain, traditional pain management practices, and mātauranga (Māori knowledge) relating to managing pain.
Methods:
14 kaumātua participated in interviews or a hui/focus group. Methods honoured tikanga (Māori protocol) and centralised whanaungatanga (relationships). Interviews and the hui/focus group were transcribed, and reflexive thematic analysis was conducted.
Results:
Three themes were developed: 1. The Multidimensional Aspects of Pain: Pain stretched beyond the physical and encompassed emotional and mental trauma, wairua/spiritual pain, grief from the loss of loved ones, contamination of the environment or breaches of tikanga/protocol. Some mamae/pain was described as everlasting, passing between people or generations. 2.Whakawhanaungatanga/Relationships: Healing through Connection. Healing of pain was seen to occur through strengthening connections with people, the spiritual realm, the natural world, and with papakāinga (one’s ancestral homeland). 3.Tino Rangatiratanga/Self-determination: Strength to Self-Manage Pain. Self-reliance to manage pain and self-determination to make health decisions were critical, and a stoical approach to pain was described. Stoicism was noted to avoid perceptions of weakness and burdening whānau/family, but may inhibit emotional expression, connection and healing.
Conclusions:
Mātauranga/Māori knowledge emphasises that pain and its healing should be considered multidimensional, incorporating physical, mental, and relational components, existing in the spiritual realm and incorporating links between people, places, the past and future. Individuals may approach pain with a stoical approach, which may have both positive and negative features. Pain services may wish to incorporate this knowledge of the spiritual, social and psychological aspects of pain and pain management to provide more meaningful care for people with pain.
A permutation-based funnel plot for subgroup analysis
Authors: Veltri Carlo , Kirsch Bodo , Kulmann Hermann 
Published: August 2023

Abstract
This article presents an extension to the Subgroup Explorer, an interactive R Shiny app used for explorative post-hoc subgroup screening in clinical trials. The original method calculates point estimates for all subgroups in a clinical trial and visualizes them in a scatter plot. The proposed extension introduces confidence intervals for the treatment effect estimates, obtained through the inversion of permutation tests. The confidence intervals are constructed for a larger number of point estimates, allowing for a twodimensional confidence region along the funnel plot. The method's performance is evaluated on synthetic clinical trial data.