bluuebunny/crossref_metadata_2025_split huggingface dataset:
DETERMINAN FAKTOR PENYEBAB KEJADIAN WASTING DI WILAYAH KERJA PUSKESMAS MUARA LABUH KABUPATEN SOLOK SELATAN
Authors: Noflidaputri Resty , Reni Gusti , Sari Mila 
Published: February 2023

<p><em>Wasting menjadi masalah kesehatan masyarakat yang penting karena memiliki dampak yang besar karena menyangkut kualitas modal sumber daya manusia di masa mendatang.Dari Laporan Puskesmas Muara Labuh bulan Agustus tahun 2021 jumlah balita kurus 78 orang (3,39%) dari 2300 balita yang ditimbang.Tujuan penelitian ini adalah Untuk mengetahui </em><em>Determinan Faktor Penyebab Kejadian Wasting di Wilayah Kerja Puskesmas Muara Labuh Kabupaten Solok Selatan</em><em>. Jenis penelitian ini survey analitik dengan desain case control. Penelitian ini dilaksanakan pada bulan Juli 2021 - Maret 2022 di Wilayah Kerja Puskesmas Muara Labuh. Populasi dalam penelitian ini adalah Seluruh Balita Wasting yang berdomisili di wilayah Kerja Puskesmas Muara Labuh berjumlah 78 orang. Sampel dalam penelitian ini dengan teknik sampel Purposive Sampling. sampel yang digunakan 100 orang (50 kasus dan 50 kontrol), serta instrumen yang digunakan adalah Kuesioner dan dianalisis dengan univariat dan bivariat dengan uji statistic chi-square. Hasil penelitian menunjukkan bahwa lebih dari separuh responden yaitu sebanyak 54 responden (55%) sudah memiliki pola makan yang baik, 67 responden (67%) tidak memiliki penyakit diare, 55 responden (55%) sudah memiliki sanitasi yang memenuhi syarat, 56 responden (56%) memiliki pola asuh yang kurang baik. Uji statistik menunjukkan bahwa ada hubungan yang bermakna antara pola makan(p=0,002; OR =41,00), Sanitasi(p=0,0001 ;OR=19,452), Pola Asuh (p=0,002; OR = 10,630) dan penyakit infeksi(p=0,002 ; OR=10,630.Disimpulkan Pola makan merupakan variabel yang paling berpengaruh dengan kejadian wasting dengan OR = 41,00.Diharapkan kepada ibu lebih memperhatikan asupan gizi untuk anak mereka sehingga gizi pada anak terpenuhi.</em><em></em></p>
Bamboo Ceiling Reframed ViMLOC Slides
Authors: Vong Silvia 
Published: February 2023

<p>A PowerPoint slide file for a presentation to members of the Visible Minority Librarians of Canada (ViMLOC), Chinese American Librarian Association (CALA), and Asian Pacific American Librarians Association (APALA). The presentation is a summary of a study conducted in 2019 with librarians that identify as Asian and their experiences with entering or working toward management roles. A book chapter was published in 2022, as a part of a commitment to transparency to the Asian librarian community, the study will be presented to the groups. </p>
A training program to increase collaboration between interpreter and therapists in psychotherapy with resettled refugees.
Authors: Rashmi Gangamma  , Shaelise Tor  
Published: February 2023

Drawing from the framework of community-academic partnerships, we describe the development and implementation of a training module to increase collaboration between interpreters and therapists in interpreter-mediated psychotherapy with refugees. Beginning with community engagement with local agencies and leaders to identify barriers to accessing psychotherapy services in the resettled refugee populations, this project involved multiple layers of collaboration to include multiple perspectives. The program was funded by a local community foundation and was implemented in three phases. In the first phase we identified key community partners and stakeholders with first-hand knowledge of the needs of refugee populations. Phase two involved a two-day workshop for student therapists from different disciplines and interpreters working in the field. Phase three included a follow up to re-assess challenges in the field and refine our training. The need to build early collaboration between therapists and interpreters was highlighted throughout the development and implementation of the project. We discuss the project’s impact, challenges encountered, and implications of lessons learned in developing community-engaged partnerships for graduate programs as a way of promoting social justice in practitioner training.
Network meta-analysis of intravitreal conbercept as an adjuvant to vitrectomy for proliferative diabetic retinopathy
Authors: Wang Weiwei , Qu Chaoyi , Yan Huanhuan 
Published: February 2023

PurposeIntravitreal Conbercept (IVC) has been shown to be effective in treating proliferative diabetic retinopathy (PDR) as an adjuvant in pars plana vitrectomy (PPV); however, the best timing of IVC injection remains unknown. This network meta-analysis (NMA) sought to ascertain the comparative efficacy of different timings of IVC injection as an adjuvant to PPV on PDR.MethodsA comprehensive literature search was conducted in PubMed, EMBASE, and the Cochrane Library to identify relevant studies published before August 11, 2022. According to the mean time of IVC injection before PPV, the strategy was defined as very long interval if it was &gt; 7 days but ≤ 9 days, long interval if it was &gt; 5 days but ≤ 7 days, mid interval if it was &gt; 3 days but ≤ 5 days, and short interval if it was ≤ 3 days, respectively. The strategy was defined as perioperative IVC if IVC was injected both before and at the end of PPV, and the strategy was intraoperative IVC if injected immediately at the end of PPV. The mean difference (MD) and odds ratio (OR) with corresponding 95% confidence interval (CI) for continuous and binary variables, respectively, were computed through network meta-analysis using Stata 14.0 MP.ResultsEighteen studies involving 1149 patients were included. There was no statistical difference between intraoperative IVC and control in treating PDR. Except for a very long interval, preoperative IVC significantly shortened operation time, and reduced intraoperative bleeding and iatrogenic retinal breaks. Long and short intervals reduced endodiathermy application, and mid and short intervals reduced postoperative vitreous hemorrhage. Moreover, long and mid intervals improved BCVA and central macular thickness. However, very long interval was associated with an increased risk of postoperative vitreous hemorrhage (RR: 3.27, 95%CI: 1.84 to 5.83). Moreover, mid interval was better than intraoperative IVC in shortening operation time (MD: -19.74, 95%CI: -33.31 to -6.17).ConclusionsThere are no discernible effects of intraoperative IVC on PDR, but preoperative IVC, except for very long interval, is an effective adjuvant to PPV for treating PDR.
Polysaccharide extracted from pomelo fruitlets attenuate hepatic lipid accumulation in hybrid groupers (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
Authors: Zou Cuiyun , Fang Yuke , Lin Nuoyi , Xiao Gengsheng , Lin Li , Liu Huifan 
Published: February 2023

IntroductionPomelo is one of the most consumed fruits due to its distinct flavor and sour taste, while large quantities of pomelo fruitlets discard during cultivation and most of them are disposed of as wastes. Such an issue has led to some research on how to make a high value-added reutilization of these fruitlets. Therefore, it was aimed to determine the structural characteristics of the polysaccharide of pomelo fruitlets and evaluate its attenuating effect on the hepatic lipid accumulation in hybrid groupers (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀).Methods and resultsIn this research, YZ-0.5A is a 15,332 Da NaCl-soluble polysaccharide extracted from pomelo fruitlet which was characterized to mainly contain galactose and galacturonic acid and its putative structure was proven to be →2,4)- α-L-Rhap-(1→4)-α-D-GalAp-(1→4)-α-D-GalAp-(1→ with 3 branches. In vivo study, five isolipidic diets (containing 15% lipid) were fed to the groupers with an initial weight of 13.46 ± 0.08 g for 8 weeks, of which the dietary level of YZ-0.5A was 0 mg/kg (control), 150 mg/kg, 300 mg/kg, 600 mg/kg and 1200 mg/kg respectively. We found that the treatment of YZ-0.5A, especially 600 mg/kg, exerted an improved effect on the excessive lipid accumulation in grouper fed with a high-fat diet. In vitro, three graded concentrations of YZ-0.5A (75, 150 or 300 μg/ml) were added to the grouper primary hepatocytes respectively after incubation with 20% lipid emulsion (2 ml/L). The signs of recovery on morphological features observed under examined by histological evaluation supported the lipid lowering effect of YZ0.5-A. Further investigation showed that YZ0.5-A mitigated lipid emulsion-induced irregular lipid deposition by regulating various lipometabolism-related indicators, thereby alleviating oxidative stress and apoptosis. DiscussionOverall results exhibited the therapeutic potential of YZ0.5-A and elucidated its underlying mechanism in the fish with excessive lipid deposition, which first suggested the feasibility of reprocessing discarded pomelo fruitlet as medicine in aquaculture.
A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia
Authors: Asare Paul Tetteh , Lee Chi-Hsien , Hürlimann Vera , Teo Youzheng , Cuénod Aline , Akduman Nermin , Gekeler Cordula , Afrizal Afrizal , Corthesy Myriam , Kohout Claire , Thomas Vincent , de Wouters Tomas , Greub Gilbert , Clavel Thomas , Pamer Eric G. , Egli Adrian , Maier Lisa , Vonaesch Pascale 
Published: February 2023

IntroductionMicrobial isolates from culture can be identified using 16S or whole-genome sequencing which generates substantial costs and requires time and expertise. Protein fingerprinting via Matrix-assisted Laser Desorption Ionization–time of flight mass spectrometry (MALDI-TOF MS) is widely used for rapid bacterial identification in routine diagnostics but shows a poor performance and resolution on commensal bacteria due to currently limited database entries. The aim of this study was to develop a MALDI-TOF MS plugin database (CLOSTRI-TOF) allowing for rapid identification of non-pathogenic human commensal gastrointestinal bacteria.MethodsWe constructed a database containing mass spectral profiles (MSP) from 142 bacterial strains representing 47 species and 21 genera within the class Clostridia. Each strain-specific MSP was constructed using &gt;20 raw spectra measured on a microflex Biotyper system (Bruker-Daltonics) from two independent cultures.ResultsFor validation, we used 58 sequence-confirmed strains and the CLOSTRI-TOF database successfully identified 98 and 93% of the strains, respectively, in two independent laboratories. Next, we applied the database to 326 isolates from stool of healthy Swiss volunteers and identified 264 (82%) of all isolates (compared to 170 (52.1%) with the Bruker-Daltonics library alone), thus classifying 60% of the formerly unknown isolates.DiscussionWe describe a new open-source MSP database for fast and accurate identification of the Clostridia class from the human gut microbiota. CLOSTRI-TOF expands the number of species which can be rapidly identified by MALDI-TOF MS.
Genomic and clinical characteristics of carbapenem-resistant Enterobacter cloacae complex isolates collected in a Chinese tertiary hospital during 2013–2021
Authors: Han Mei , Liu Chang , Xie Hui , Zheng Jie , Zhang Yan , Li Chuchu , Shen Han , Cao Xiaoli 
Published: February 2023

ObjectiveTo analyze the molecular epidemiology of carbapenem-resistant Enterobacter cloacae complex (CREC) by whole-genome sequencing and to explore its clinical characteristics.MethodsEnterobacter cloacae complex isolates collected in a tertiary hospital during 2013–2021 were subjected to whole-genome sequencing to determine the distribution of antimicrobial resistance genes (ARGs), sequence types (STs), and plasmid replicons. A phylogenetic tree of the CREC strains was constructed based on the whole-genome sequences to analyze their relationships. Clinical patient information was collected for risk factor analysis.ResultsAmong the 51 CREC strains collected, blaNDM-1 (n = 42, 82.4%) was the main carbapenem-hydrolyzing β-lactamase (CHβL), followed by blaIMP-4 (n = 11, 21.6%). Several other extended-spectrum β-lactamase-encoding genes were also identified, with blaSHV-12 (n = 30, 58.8%) and blaTEM-1B (n = 24, 47.1%) being the predominant ones. Multi-locus sequence typing revealed 25 distinct STs, and ST418 (n = 12, 23.5%) was the predominant clone. Plasmid analysis identified 15 types of plasmid replicons, among which IncHI2 (n = 33, 64.7%) and IncHI2A (n = 33, 64.7%) were the main ones. Risk factor analysis showed that intensive care unit (ICU) admission, autoimmune disease, pulmonary infection, and previous corticosteroid use within 1 month were major risk factors for acquiring CREC. Logistic regression analysis showed that ICU admission was an independent risk factor for CREC acquisition and was closely related with acquiring infection by CREC with ST418.ConclusionBlaNDM-1 and blaIMP-4 were the predominant carbapenem resistance genes. ST418 carrying BlaNDM-1 not only was the main clone, but also circulated in the ICU of our hospital during 2019–2021, which highlights the necessity for surveillance of this strain in the ICU. Furthermore, patients with risk factors for CREC acquisition, including ICU admission, autoimmune disease, pulmonary infection, and previous corticosteroid use within 1 month, need to be closely monitored for CREC infection.
Association between preoperative hematocrit and postoperative 30-day mortality in adult patients with tumor craniotomy
Authors: Liu Yufei , Li Lunzou , Hu Haofei , Yang Jihu , Zhang Xiejun , Chen Lei , Chen Fanfan , Hao Shuyu , Li Weiping , Huang Guodong 
Published: February 2023

BackgroundThe purpose of this research was to synthesize the American College of Surgeons National Surgical Quality Improvement Program database to investigate the link between preoperative hematocrit and postoperative 30-day mortality in patients with tumor craniotomy.MethodsA secondary retrospective analysis of electronic medical records of 18,642 patients with tumor craniotomy between 2012 and 2015 was performed. The principal exposure was preoperative hematocrit. The outcome measure was postoperative 30-day mortality. We used the binary logistic regression model to explore the link between them and conducted a generalized additive model and smooth curve fitting to investigate the link and its explicit curve shape. We conducted sensitivity analyses by converting a continuous HCT into a categorical variable and calculated an E-value.ResultsA total of 18,202 patients (47.37% male participants) were included in our analysis. The postoperative 30-day mortality was 2.5% (455/18,202). After adjusting for covariates, we found that preoperative hematocrit was positively associated with postoperative 30-day mortality (OR = 0.945, 95% CI: 0.928, 0.963). A non-linear relationship was also discovered between them, with an inflection point at a hematocrit of 41.6. The effect sizes (OR) on the left and right sides of the inflection point were 0.918 (0.897, 0.939) and 1.045 (0.993, 1.099), respectively. The sensitivity analysis proved that our findings were robust. The subgroup analysis demonstrated that a weaker association between preoperative hematocrit and postoperative 30-day mortality was found for patients who did not use steroids for chronic conditions (OR = 0.963, 95% CI: 0.941–0.986), and a stronger association was discovered in participants who used steroids (OR = 0.914, 95% CI: 0.883–0.946). In addition, there were 3,841 (21.1%) cases in the anemic group (anemia is defined as a hematocrit (HCT) &lt;36% in female participants and &lt;39% in male participants). In the fully adjusted model, compared with the non-anemic group, patients in the anemic group had a 57.6% increased risk of postoperative 30-day mortality (OR = 1.576; 95% CI: 1.266, 1.961).ConclusionThis study confirms that a positive and nonlinear association exists between preoperative hematocrit and postoperative 30-day mortality in adult patients undergoing tumor craniotomy. Preoperative hematocrit was significantly associated with postoperative 30-day mortality when the preoperative hematocrit was &lt;41.6.
Value of neutrophil-to-lymphocyte ratio for diagnosing sarcopenia in patients undergoing maintenance hemodialysis and efficacy of Baduanjin exercise combined with nutritional support
Authors: Wang Jun , Xu Mei-chang , Huang Li-juan , Li Bei , Yang Lei , Deng Xu 
Published: February 2023

ObjectiveTo investigate the value of neutrophil-to-lymphocyte ratio (NLR) for diagnosing sarcopenia in patients undergoing maintenance hemodialysis (MHD) and efficacy of Baduanjin exercise combined with nutritional support on MHD patients with sarcopenia.MethodsA total of 220 patients undergoing MHD in MHD centers were selected, among which 84 had occurred with sarcopenia confirmed by measurements from the Asian Working Group for Sarcopenia. Data were collected for analyzing the influencing factors that lead to the onset of sarcopenia in MHD patients with the use of one-way analysis of variance and multivariate logistic regression. The role of NLR in the diagnosis of sarcopenia was explored, and its correlation with relevant diagnostic measurement performance such as grip strength, gait speed and skeletal muscle mass index was analyzed. In the end, some 74 patients with sarcopenia that qualify for further intervention and observation standards were divided into observation group (Baduanjin exercise plus nutritional support) and control group (nutritional support only), which were both intervened for 12 weeks. A total of 68 patients finished all interventions, with 33 patients in the observation group and 35 in the control group. The grip strength, gait speed, skeletal muscle mass index as well as the NLR were compared between the two groups.ResultsWith the employment of multivariate logistic regression analysis, it was found that age, hemodialysis duration and NLR were risk factors for the onset of sarcopenia in MHD patients (P &lt; 0.05). The area under ROC curve for NLR of MHD patients with sarcopenia was 0.695, and NLR was negatively correlated with a biochemical indicator—human blood albumin (P &lt; 0.05). NLR was also negatively correlated with patient's grip strength, gait speed and skeletal muscle mass index, with the same correlation found in sarcopenia patients (all P &lt; 0.05). After intervention, patient's grip strength and gait speed were both higher, and the NLR lower in the observation group than those in the control group (P &lt; 0.05).ConclusionThe occurrence of sarcopenia in MHD patients is associated with patient's age, hemodialysis duration and NLR. Therefore, it has been concluded that NLR has certain values in the diagnosis of sarcopenia in patients undergoing MHD. Moreover, the muscular strength can be enhanced and inflammation decreased in sarcopenia patients through nutritional support and physical exercise, i.e., Bajinduan exercise.
Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke
Authors: Fast Lea , Temuulen Uchralt , Villringer Kersten , Kufner Anna , Ali Huma Fatima , Siebert Eberhard , Huo Shufan , Piper Sophie K. , Sperber Pia Sophie , Liman Thomas , Endres Matthias , Ritter Kerstin 
Published: February 2023

BackgroundAccurate prediction of clinical outcomes in individual patients following acute stroke is vital for healthcare providers to optimize treatment strategies and plan further patient care. Here, we use advanced machine learning (ML) techniques to systematically compare the prediction of functional recovery, cognitive function, depression, and mortality of first-ever ischemic stroke patients and to identify the leading prognostic factors.MethodsWe predicted clinical outcomes for 307 patients (151 females, 156 males; 68 ± 14 years) from the PROSpective Cohort with Incident Stroke Berlin study using 43 baseline features. Outcomes included modified Rankin Scale (mRS), Barthel Index (BI), Mini-Mental State Examination (MMSE), Modified Telephone Interview for Cognitive Status (TICS-M), Center for Epidemiologic Studies Depression Scale (CES-D) and survival. The ML models included a Support Vector Machine with a linear kernel and a radial basis function kernel as well as a Gradient Boosting Classifier based on repeated 5-fold nested cross-validation. The leading prognostic features were identified using Shapley additive explanations.ResultsThe ML models achieved significant prediction performance for mRS at patient discharge and after 1 year, BI and MMSE at patient discharge, TICS-M after 1 and 3 years and CES-D after 1 year. Additionally, we showed that National Institutes of Health Stroke Scale (NIHSS) was the top predictor for most functional recovery outcomes as well as education for cognitive function and depression.ConclusionOur machine learning analysis successfully demonstrated the ability to predict clinical outcomes after first-ever ischemic stroke and identified the leading prognostic factors that contribute to this prediction.
Case report: JAK inhibition as promising treatment option of fatal RVCLS due to TREX1 mutation (pVAL235Glyfs*6)
Authors: Ufer Friederike , Ziegler Susanne M. , Altfeld Marcus , Friese Manuel A. 
Published: February 2023

IntroductionAutosomal dominant mutations in the C-terminal part of TREX1 (pVAL235Glyfs*6) result in fatal retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCLS) without any treatment options. Here, we report on a treatment of a RVCLS patient with anti-retroviral drugs and the janus kinase (JAK) inhibitor ruxolitinib.MethodsWe collected clinical data of an extended family with RVCLS (TREX1 pVAL235Glyfs*6). Within this family we identified a 45-year-old woman as index patient that we treated experimentally for 5 years and prospectively collected clinical, laboratory and imaging data.ResultsWe report clinical details from 29 family members with 17 of them showing RVCLS symptoms. Treatment of the index patient with ruxolitinib for &gt;4 years was well-tolerated and clinically stabilized RVCLS activity. Moreover, we noticed normalization of initially elevated CXCL10 mRNA in peripheral blood monocular cells (PBMCs) and a reduction of antinuclear autoantibodies.DiscussionWe provide evidence that JAK inhibition as RVCLS treatment appears safe and could slow clinical worsening in symptomatic adults. These results encourage further use of JAK inhibitors in affected individuals together with monitoring of CXCL10 transcripts in PBMCs as useful biomarker of disease activity.