bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basolateral Amygdala Corticotrophin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory
Authors: Hafenbreidel Madalyn , Briggs Sherri B. , Arza Meghana , Bonthu Shalakha , Fisher Cadence , Tiller Annika , Hall Alice B. , Reed Shayna , Mayorga Natasha , Lin Li , Khan Susan , Cameron Michael D. , Rumbaugh Gavin , Miller Courtney A. 
Published: May 2023

AbstractInhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory. The effect is highly selective, as NMII inhibition has no effect in other relevant brain regions (e.g. dorsal hippocampus [dPHC], nucleus accumbens [NAc]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (COC). To investigate a potential source of this specificity, pharmacokinetic differences in METH and COC brain exposure were examined. Replicating METH’s longer half-life with COC did not render the COC association susceptible to disruption by NMII inhibition. Therefore, transcriptional differences were next assessed. Comparative RNA-seq profiling in the BLA, dHPC and NAc following METH or COC conditioning identifiedcrhr2, which encodes the corticotrophin releasing factor receptor 2 (CRF2), as uniquely upregulated by METH in the BLA. CRF2 antagonism with Astressin-2B (AS2B) had no effect on METH-associated memory after consolidation, allowing for determination of CRF2 influences on NMII-based susceptibility after METH conditioning. Pretreatment with AS2B occluded the ability of Blebb to disrupt an established METH-associated memory. Alternatively, the Blebb-induced, retrieval-independent memory disruption seen with METH was mimicked for COC when combined with CRF2 overexpression in the BLA and its ligand, UCN3 during conditioning. These results indicate that BLA CRF2 receptor activation during learning can prevent stabilization of the actin-myosin cytoskeleton supporting the memory, rendering it vulnerable to disruption via NMII inhibition. CRF2 represents an interesting target for BLA-dependent memory destabilization via downstream effects on NMII.
Seasonal Variation in Bacterial Community Structures of Mangrove Sediments
Authors: Wang Nan , Liu Lu , Guo Zixiao , Xu Shaohua , Zhang Rufan , Zhong Cairong , Shi Suhua , He Ziwen 
Published: May 2023

AbstractClimate change globally and sea level rise affect the mangrove ecosystem. The high diversity and temporal heterogeneity of the mangrove ecosystem will lead to a high diversity of sediment bacterial community structure and function. However, seasonal variations and potential assembly mechanisms of sediment bacterial communities in mangrove ecosystems remain to be discovered. We collected rhizosphere sediments and bulk sediments fromKandelia obovataandAegiceras corniculatumat three locations covering Dongzhai Harbour in spring, summer, autumn, and winter, and sequenced 16S rRNAs. The results indicated that the alpha and beta diversity of bacterial communities in mangrove sediments differed significantly between seasons, and the bacterial communities in rhizosphere sediments had smaller seasonal changes and were more stable than those in bulk sediment bacterial communities. The seasonal changes in carbon, nitrogen content, and pH were the main influencing factors. The stochastic process dominated the assembly of bacterial communities in mangrove sediments. The assembly of bacterial communities varies between seasons. We found that the proportion of dispersal limitation was significantly negatively correlated with the carbon and nitrogen content in the sediment. Compared with bulk components, the dispersal limitation of bacterial communities in rhizosphere sediments accounted for a lower proportion of community construction, which might be caused by higher carbon and nitrogen content conditions in rhizosphere sediments. We found that beta diversity based on Bray-Curtis distance was significantly positively correlated with dispersal limitation, which explained why the beta diversity of bacterial communities in rhizosphere sediments was significantly lower than that of bulk components. This study increases the understanding of the responses of mangrove bacterial communities to seasonal change and may be beneficial for the protection of mangrove ecosystems in the face of climate change.
Analysis of barriers of mHealth adoption in the context of sustainable operational practices in health care supply chains
Authors: Swain Suchismita , Muduli Kamalakanta , Kumar Anil , Luthra Sunil 
Published: May 2023

PurposeThe goal of this research is to analyse the obstacles to the implementation of mobile health (mHealth) in India and to gain an understanding of the contextual inter-relationships that exist amongst those obstacles.Design/methodology/approachPotential barriers and their interrelationships in their respective contexts have been uncovered. Using MICMAC analysis, the categorization of these barriers was done based on their degree of reliance and driving power (DP). Furthermore, an interpretive structural modeling (ISM) framework for the barriers to mHealth activities in India has been proposed.FindingsThe study explores a total of 15 factors that reduce the efficiency of mHealth adoption in India. The findings of the Matrix Cross-Reference Multiplication Applied to a Classification (MICMAC) investigation show that the economic situation of the government, concerns regarding the safety of intellectual technologies and privacy issues are the primary obstacles because of the significant driving power they have in mHealth applications.Practical implicationsPromoters of mHealth practices may be able to make better plans if they understand the social barriers and how they affect each other; this leads to easier adoption of these practices. The findings of this study might be helpful for governments of developing nations to produce standards relating to the deployment of mHealth; this will increase the efficiency with which it is adopted.Originality/valueAt this time, there is no comprehensive analysis of the factors that influence the adoption of mobile health care with social cognitive theory in developing nations like India. In addition, there is a lack of research in investigating how each of these elements affects the success of mHealth activities and how the others interact with them. Because developed nations learnt the value of mHealth practices during the recent pandemic, this study, by investigating the obstacles to the adoption of mHealth and their inter-relationships, makes an important addition to both theory and practice.
Managing government commissioning and philanthropic expectations: earnings management in Australian nonprofit disability service providers
Authors: Gilchrist David John , Etheridge Dane , Liu Zhangxin (Frank) 
Published: May 2023

PurposeThe purpose of this study is to investigate the prevalence of earnings management in the Australian not-for-profit (NFP) disability service providers sector, as well as to understand the motivations for and implications of such practices. This research is important for stakeholders, such as members and funders, as well as the broader Australian community, considering the significant financial resources allocated to these organizations from the public purse.Design/methodology/approachThe authors employ a longitudinal dataset containing financial data from 154 Australian NFP disability service providers, collected over a two-year period (2015–2016). Through the analysis of detailed balance sheets and income statements, the authors seek to uncover evidence of earnings management practices in this sector. The study’s results provide valuable insights into the behaviour of the charitable human services sector.FindingsThe findings reveal that Australian NFP disability service providers engage in earnings management practices, primarily aimed at reducing reported profits to meet the normative financial expectations of stakeholders, such as public sector funders and philanthropists. The executives of these organizations strive to report profits close to zero, being cautious not to report a loss, which might raise concerns about their sustainability.Originality/valueThe authors contribute to the existing literature on earnings management in the NFP sector by focussing on Australian disability service providers, an area that has been under-researched due to a lack of suitable data. The results offer insights into the incentives and implications of earnings management practices in this sector and highlight the need for a revaluation of accounting standards, reporting requirements and audit arrangements applicable to the NFP sector.
Alpha-Stim AID cranial electrotherapy stimulation (CES) anxiety treatment: anxiety, depression and health-related quality-of-life outcomes in primary health-care social prescribing services
Authors: Griffiths Chris , da Silva Ksenija , Jiang Harmony , Walker Kate , Smart David , Zafar Azhar , Deeks Sarah , Galvin Sinead , Shah Taz 
Published: May 2023

Purpose
This study aims to evaluate the effect of Alpha-Stim Anxiety, Insomnia and Depression (AID) cranial electrotherapy stimulation (CES) on anxiety, depression and health-related quality of life for primary care social prescribing service patients with anxiety symptoms.

Design/methodology/approach
Open-label patient cohort design with no control group. A total of 33 adult patients (average age 42 years) completed six weeks of Alpha-Stim AID use. Pre- and post-intervention assessment with participant self-report measures: Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder (GAD-7) and European Quality of Life Five Dimension (EQ-5D-5L).

Findings
Reliable improvement and remission rates, respectively, were 53.39% and 33.3% for GAD-7; 46.7% and 29.5% for PHQ-9. There was a significant improvement in GAD-7 and PHQ-9 with large effect sizes. EQ-5D-5L results showed significant improvements in health-related quality of life. Perceived quality of life increased by 0.17 on the health index score, with the intervention adding 1.68 quality-adjusted life years (QALYs).

Practical implications
Alpha-Stim AID can be delivered through a primary health-care social prescribing service and most patients will use as prescribed and complete treatment course. Alpha-Stim AID CES may be an effective anxiety and depression treatment for people with anxiety symptoms. The widespread roll-out of Alpha-Stim AID in health-care systems should be considered.

Originality/value
To the best of the authors’ knowledge, this is the first study to respond to the UK’s National Institute for Health and Care (NICE) request for the collection of real-world data to understand better Alpha-Stim AID in relation to people’s treatment uptake, response rates and treatment completion rates (NICE, 2021).
Cumulative exposure to immunomodulators increases risk of cervical neoplasia in women with inflammatory bowel disease
Authors: Kreijne J. E. , Goetgebuer R. L. , Erler N. S. , De Boer N. K. , Siebers A. G. , Dijkstra G. , van Kemenade F. A. , Hoentjen F. , Oldenburg B. , van der Meulen A. E. , Ponsioen C. I. J. , Pierik M. J. , van der Woude C. J. , de Vries A. C. ,   the Dutch Initiative on Crohn and Colitis (ICC)
Published: May 2023

SummaryBackgroundWomen with inflammatory bowel disease (IBD) are at increased risk of high‐grade cervical intraepithelial neoplasia and cervical cancer (CIN2+).AimTo assess the association between cumulative exposure to immunomodulators (IM) and biologic agents (BIO) for IBD and CIN2+MethodsAdult women diagnosed with IBD before December 31st 2016 in the Dutch IBD biobank with available cervical records in the nationwide cytopathology database were identified. CIN2+ incidence rates in IM‐ (i.e., thiopurines, methotrexate, tacrolimus and cyclosporine) and BIO‐ (anti‐tumour necrosis factor, vedolizumab and ustekinumab) exposed patients were compared to unexposed patients and risk factors were assessed. Cumulative exposure to immunosuppressive drugs was evaluated in extended time‐dependent Cox‐regression models.ResultsThe study cohort comprised 1981 women with IBD: 99 (5%) developed CIN2+ during median follow‐up of 17.2 years [IQR 14.6]. In total, 1305 (66%) women were exposed to immunosuppressive drugs (IM 58%, BIO 40%, IM and BIO 33%). CIN2+ risk increased per year of exposure to IM (HR 1.16, 95% CI 1.08–1.25). No association was observed between cumulative exposure to BIO or both BIO and IM and CIN2+. In multivariate analysis, smoking (HR 2.73, 95%CI 1.77–4.37) and 5‐yearly screening frequency (HR 1.74, 95% CI 1.33–2.27) were also risk factors for CIN2+ detection.ConclusionCumulative exposure to IM is associated with increased risk of CIN2+ in women with IBD. In addition to active counselling of women with IBD to participate in cervical screening programs, further assessment of the benefit of intensified screening of women with IBD on long‐term IM exposure is warranted.
Accelerated death of megakaryocytes from Wiskott–Aldrich syndrome patients
Authors: Obydennyi Sergei I. , Kuznetsova Sofya A. , Fedyanina Olga S. , Khoreva Anna , Voronin Kirill , Mazurov Alexey V. , Glukhova Anna A. , Artemenko Elena O. , Ataullakhanov Fazoil I. , Maschan Alexey A. , Novichkova Galina A. , Shcherbina Anna , Panteleev Mikhail A. 
Published: May 2023

SummaryWiskott–Aldrich syndrome (WAS) is an X‐linked recessive disorder caused by WAS gene mutations resulting in haematopoietic/immune cell defects. Recent studies report accelerated death of WAS platelets and lymphocytes. Data on megakaryocyte (MK) maturation, viability and their possible role in thrombocytopenia development in WAS are limited. In this study we evaluate the MK viability and morphology in untreated, romiplostim‐treated WAS patients compared with normal controls. The study included 32 WAS patients and 17 healthy donors. MKs were captured from bone marrow aspirates by surface‐immobilized anti‐GPIIb‐IIIa antibody. Viability (by phosphatidylserine [PS] externalization), distribution by maturation stages and size of MK were determined by light microscopy. MK distribution by maturation stages in patients differed from controls. 40 ± 22% of WAS MKs versus 23 ± 11% of normal MKs were at maturation stage 3 (p = 0.02), whereas 24 ± 20% in WAS and 39 ± 14% in controls had megakaryoblast morphology (p = 0.05). Romiplostim treatment changed the MK maturation stages distribution close to normal. PS‐positive (PS+) MK in WAS was significantly higher (21 ± 21%) than in healthy controls (2 ± 4%, p < 0.01). WAS patients with more damaging truncating mutations and higher disease score had higher PS+ MK fraction (Spearman r = 0.6, p < 0.003). We conclude that WAS MKs have increased cell death tendency and changes in maturation pattern. Both could contribute to thrombocytopenia in WAS patients.
Diffusion tensor imaging‐based machine learning for IDH wild‐type glioblastoma stratification to reveal the biological underpinning of radiomic features
Authors: Wang Zilong , Guan Fangzhan , Duan Wenchao , Guo Yu , Pei Dongling , Qiu Yuning , Wang Minkai , Xing Aoqi , Liu Zhongyi , Yu Bin , Zheng Hongwei , Liu Xianzhi , Yan Dongming , Ji Yuchen , Cheng Jingliang , Yan Jing , Zhang Zhenyu 
Published: May 2023

AbstractIntroductionThis study addresses the lack of systematic investigation into the prognostic value of hand‐crafted radiomic features derived from diffusion tensor imaging (DTI) in isocitrate dehydrogenase (IDH) wild‐type glioblastoma (GBM), as well as the limited understanding of the biological interpretation of individual DTI radiomic features and metrics.AimsTo develop and validate a DTI‐based radiomic model for predicting prognosis in patients with IDH wild‐type GBM and reveal the biological underpinning of individual DTI radiomic features and metrics.ResultsThe DTI‐based radiomic signature was an independent prognostic factor (p < 0.001). Incorporating the radiomic signature into a clinical model resulted in a radiomic‐clinical nomogram that predicted survival better than either the radiomic model or clinical model alone, with a better calibration and classification accuracy. Four categories of pathways (synapse, proliferation, DNA damage response, and complex cellular functions) were significantly correlated with the DTI‐based radiomic features and DTI metrics.ConclusionThe prognostic radiomic features derived from DTI are driven by distinct pathways involved in synapse, proliferation, DNA damage response, and complex cellular functions of GBM.
Drainage pattern of the splenic flexure vein and its accompanying arteries using three‐dimensional computed tomography angiography: a single‐centre study of 600 patients
Authors: Sakamoto Kyoko , Okabayashi Koji , Matsumoto Shunsuke , Matsui Shimpei , Seishima Ryo , Shigeta Kohei , Kitagawa Yuko 
Published: May 2023

AbstractAimThe splenic flexure has variable vascular anatomy, and the details of the venous forms are not known. In this study, we report the flow pattern of the splenic flexure vein (SFV) and the positional relationship between the SFV and arteries such as the accessory middle colic artery (AMCA).MethodsThis was a single‐centre study using preoperative enhanced CT colonography images of 600 colorectal surgery patients. CT images were reconstructed into 3D angiography. SFV was defined as a vein flowing centrally from the marginal vein of the splenic flexure visible on CT. AMCA was defined as the artery feeding the left side of the transverse colon, separate from the left branch of the middle colic artery.ResultsThe SFV returned to the inferior mesenteric vein (IMV) in 494 cases (82.3%), the superior mesenteric vein in 51 cases (8.5%) and the splenic vein in seven cases (1.2%). The AMCA was present in 244 cases (40.7%). The AMCA branched from the superior mesenteric artery or its branches in 227 cases (93.0% of cases with existing AMCA). In the 552 cases in which the SFV returned to the IMV, superior mesenteric vein or splenic vein, the left colic artery was the most frequent artery accompanying the SFV (42.2%), followed by the AMCA (38.1%) and the left branch of the middle colic artery (14.3%).ConclusionsThe most common flow pattern of the vein in the splenic flexure is from the SFV to IMV. The SFV is frequently accompanied by the left colic artery or AMCA.
The Gospel according to civic engagement
Authors: Peñaranda Nicolette Marie 
Published: May 2023

AbstractThe author of this passage suggests that hospitality is at the heart of both Christianity and politics. They draw on the writing of Martin Luther, who argues that Christians do not live in themselves but in Christ and their neighbor. This paper invites us to consider that Christian relationships should not be individualistic, as this removes them from the community and movement that Jesus established. Rather, Christians must act collectively to combat societal issues and oppression. By choosing to get involved civically, whether through elections, community organizing, or advocacy, individuals can choose to side with either self‐interest or radical hospitality. The author suggests that choosing radical hospitality is the way to live in Christ and our neighbor, and to truly demonstrate authentic love for those around us. The author is reflecting on their decision to engage in local politics after witnessing civil unrest and racial injustices in their community. They highlight the importance of public witness as a prophetic act, grounded in faith and a desire for justice. The author draws on the teachings of Martin Luther and the tradition of the Black church as inspiration for their political engagement, which they see as a way to serve their neighbors and demonstrate their love and teachings. They also acknowledge the challenges and complexities of political leadership, especially in the face of corruption and unethical practices. Overall, the author's message is one of hope and a commitment to working towards a more equitable and hospitable community for all.
Association between COVID‐19 vaccination and 28‐day all‐cause mortality in SARS‐CoV‐2–infected older people living in residential aged care facilities
Authors: Yap Sok Shin , Low Zi Yi , Kovaleva Natalia , Tacey Mark , Hurley Kate , Harvey Penelope , Brown Sandra 
Published: May 2023

AbstractThis retrospective cross‐sectional study reviewed the association between COVID‐19 vaccination and the 28‐day all‐cause mortality amongst SARS‐CoV‐2–infected older people living in residential aged care facilities. A lower mortality rate was observed in fully vaccinated residents compared with not fully vaccinated residents. Further research is required to investigate the optimal timing of vaccination boosters and vaccine efficacy as variants evolve.
Morphology and dynamic behavior of anal pores during defecation in the ctenophore Pleurobrachia pileus
Authors: Tamm Sidney L. 
Published: May 2023

AbstractDefecation in the lobate ctenophore Mnemiopsis leidyi was recently shown to occur periodically with an ultradian rhythm through a single transient anal pore which suddenly appeared, expelled waste, and disappeared afterward. To discover whether this novel method of defecation occurs in other kinds of ctenophores, I examined individuals of Pleurobrachia pileus and Beroe cucumis. Both ctenophores were found to have two identical and permanent anal pores as described in the scientific literature and textbooks. In P. pileus, both anal pores commonly participated in a defecation, but they did so asynchronously with independent and irregular opening and closing kinetics. Individuals of P. pileus defecated with an ultradian rhythm. Closed anal pores in P. pileus and B. cucumis consisted of a continuous ectodermal epithelium overlying a continuous endodermal epithelium with a cup‐shaped group of thickened endodermal cells bearing a tuft of cilia which beats into the anal cavity. The rims of opening or closing pores were smooth and uniform without encircling muscles or fibers. This morphology and the continuity of the epithelial layers between defecations suggest that anal pores may not operate by a contractile sphincter, but by a reversible ring of tissue fusion between apposed ectodermal and endodermal epithelia to create an adjustable hole to expel waste.