bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between High-density Lipoproteins and Periodontitis
Authors: Ehteshami Ailin , Shirban Farinaz , Bagherniya Mohammad , Sathyapalan Thozhukat , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: July 2023

:
Periodontitis is one of the most typical chronic dental diseases. This inflammatory
disease can change various functions of immune cells and impair lipid metabolism
through proinflammatory cytokines. High-Density Lipoprotein (HDL) is considered protective
of the cardiovascular system. It has anti-thrombotic and anti-inflammatory effects.
In this article, we have reviewed the association between periodontitis and HDL.
Various studies have demonstrated a reverse relationship between inflammatory cytokines
and HDL. HDL contains antioxidative enzymes and proteins, whereas periopathogens
impair HDL's antioxidant function. The presence of periodontal bacteria is associated
with a low HDL level in patients with periodontitis. Genetic variants in the interleukin-
6 (IL)-6 gene and cytochrome (CYP)1A1 rs1048943 gene polymorphism are associated
with HDL levels and periodontal status. Studies showed that HDL levels improve after
treatment for periodontitis. On the one hand, periodontal pathogenic bacteria and their
metabolites and pro-inflammatory cytokines from periodontal infection can result in various
disorders of lipid metabolism and lipid peroxidation. On the other hand, hyperlipidemia
and lipid peroxidation stimulate proinflammatory cytokines, resulting in oxidative
stress and delayed wound healing, making individuals susceptible to periodontitis.
The Nanotech Potential of Curcumin in Pharmaceuticals: An Overview
Authors: Pardeshi Sagar , Mohite Popat , Rajput Tanavirsing , Puri Abhijeet 
Published: July 2023

Abstract:
It is safe to use Curcumin as a cosmetic and therapeutic ingredient in pharmaceutical products.
For the uses mentioned above and for fundamental research, it is essential to obtain pure Curcumin
from plant sources. There is a requirement for effective extraction and purification techniques that
adhere to green chemistry standards for efficiency improvement, process safety, and environmental
friendliness. Several outstanding studies have looked into the extraction and purification of Curcumin.
This review thoroughly covers the currently available curcumin extraction, synthesis, and transformation
techniques. Additionally, Curcumin's poor solubility and low absorption in the human
body have limited its potential for pharmaceutical use. However, recent developments in novel curcumin
formulations utilizing nanotechnology delivery methods have provided new approaches to
transport and maximize the human body's curcumin absorption efficiency. In this review, we explore
the various curcumin nanoformulations and the potential medicinal uses of nano curcumin. Additionally,
we review the necessary future research directions to recommend Curcumin as an excellent therapeutic
candidate.
Synthesis, Characterization, DPPH Radical Scavenging, Urease Enzyme Inhibition, Molecular Docking Simulation, and DFT Analysis of Imine Derivatives of 4-formylpyridine with Selective Detection of Cu+2 Ions
Authors: Zia Ambreen , Ali Syed Nawazish , Hasan Erum , Lateef Mehreen , Zia Syeda Rehana , Gul Sana , Bukhari Syeda Farah , Dildar Nazish 
Published: July 2023

Background::
Three imine derivatives (1, 2 & 3) have been prepared via condensation reaction
of phenyl hydrazine, 2-hydrazino pyridine and 4-methoxy aniline with 4-formyl pyridine.

Materials and Methods:
Electron impact mass spectrometry (EIMS), proton nuclear magnetic resonance
(1H-NMR), ultra violet- visible (UV-Vis) and fourier transform infrared (FTIR) spectroscopy have been
utilized for the characterization. The chemosensing properties of [4((2-phenyl hydrazono)methyl) pyridine]
(1), [2-(2-(pyridin-4-ylmethylene)hydrazinyl) pyridine] (2) & [4-methoxy-N-yl methylene) aniline]
(3) imino bases are explored for the first time in aqueous media. The photophysical properties of
chemosensors (1, 2 and 3) were examined by various cations (Na+, NH4+, Ba+2, Ni+2, Ca+2, Hg+2, Cu+2,
Mg+2, Mn+2 and Pd+2).

Results and Discussion:
The chemosensor (1) has shown very selective binding capability with copper
ions at low concentration (20 μM) without influence of any other mentioned ions. The maximum complexation
was noted with Cu+2 and 1 at pH (7-7.5). The stoichiometry binding ratio between chemosensor
(1) and Cu+2 was determined by Job’s plot and it is found to be (1:2).

Conclusion::
Current study explores the use of these Schiff bases for the first time as heterocyclic
chemosensors. DPPH radical scavenging, urease enzyme inhibition activities along with molecular docking
simulation and density functional theory (DFT) analysis of compounds 1, 2 and 3 were also explored.
Evaluation of DPP4/CD26 Potential Role for the Management of
Inflammation in COVID-19 Patients
Authors: Akbarian Fatemeh , Chafjiri Sanam Rezazadeh , Poornabi Marziye , Khani Farzaneh , Abolhasanzadeh Solmaz , Hosseini Fatemeh Sadat 
Published: July 2023

Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is re-sponsible for Coronavirus Disease 2019 (COVID-19) pandemic. Cell entry of the virus can be me-diated by several enzymes, such as ACE-2, DPP4/CD26, and TMPRSS2, upon viral membrane fu-sion through SARS-CoV-2 envelope spike glycoproteins. In docked molecular complexes, DPP4/CD26 functional receptors and viral spike proteins have a large interface, potentially leading to inflammation in severe COVID-19.

Objective:
The aim of this study is to review the role of DPP4/CD26 in the immune system and its effects on the production of cytokine storms in COVID-19. Furthermore, we hypothesize that tar-geting DPP4/CD26 as a therapeutic strategy could reduce the inflammatory complications of SARS-CoV-2 infection.

Methods:
The current review was conducted using keywords such as COVID-19, SARS-CoV-2, dipeptidyl peptidase-4, CD26, cytokine storm, and treatment to search for articles in Google Scholar and PubMed databases that were specifically oriented towards our objectives.

Results:
The regulation or inhibition of DPP4/CD26 might affect one or more stages in COVID-19 immuno- pathogenesis due to its associations with many immunological functions, such as modulat-ing the NF-kB pathway, upregulating CD86 expression, activating proliferation of T cells, and in-fluencing the antiviral response and cytokine storm in COVID-19. In this regard, the applications of DPP4/CD26 inhibitors, DPP4/CD26 siRNAs, and CD26 antibodies have been demonstrated to pre-vent cytokine storms and airway inflammation.

Conclusion:
It is suggested to utilize novel technologies such as CRISPR/Cas and chimeric antigen receptor T cells, based on their many advantages, to increase the sensitivity and specificity of future treatment methods.
Nanobots: Revolutionising the Next Generation of Biomedical Technology
and Drug Therapy
Authors: Panda Vandana , Saindane Akash , Pandey Aditya 
Published: July 2023

Abstract:
Nanoscale machines called “nanorobots” that were hitherto only futuristic ideas are set to
storm healthcare and pharmaceuticals with newer technologies for minimally invasive diagnosis, quick
and precise surgeries, and targeted drug delivery, which is challenging to achieve by conventional drug
delivery systems. Nanobots can be defined as controllable nano-sized mechanical or electromechanical
devices which are easily incorporated into cells and used for a variety of cellular functions like combating
bacteria and viruses, disposing away dead cells/tissue at the place of a wound, cell/tissue repair and
destruction of cancer cells, and also for transporting drugs to cells. Nanorobots can help avoid the untoward
effects of traditional drug delivery systems and ameliorate the efficiency of drug delivery by quickly
entering the desired cells without affecting other organs. With the advent of mobile communication,
artificial neural networks, and Information Technology, futuristic and more advanced nanobots with artificial
intelligence are in the offing. However, the challenges to this revolutionary technology are umpteen,
the major concern being their interaction inside the human body. This review explicitly expounds
on nanobots and their applications to medicine, biomedical research, and drug delivery.
Green and Eco-friendly Synthetic Strategies for Quinoxaline Derivatives
Authors: Ali Irfan , Bhatia Rohit 
Published: July 2023

Abstract:
Advancement in green synthetic methodologies has brought a revolution in heterocyclic synthesis.
Green synthesis has bypassed the classical procedures involving toxic/hazardous solvents or catalysts
and improved the current environmental safety standards by many folds. Green chemistry research
has continuously made significant contributions to the development of heterocyclic scaffolds both at laboratory
and commercial scales. Researchers are continuously developing and exploring the principles of
green chemistry for the development of novel therapeutic agents. Quinoxaline lies in the category of versatile
heterocyclic motifs, which possesses a wide diversity in its derivatives as well as a broad profile of
its therapeutic potential. In the past decades, many new green synthetic protocols have been developed
and employed successfully for the synthesis of quinoxaline derivatives. These include the use of reusable
nanocatalysts, polymers, various green solvents, tonsils, catalysts, water as a catalyst, microwave irradiation,
ultrasonic waves, non-toxic metal catalysts, surfactants, etc. The present review focuses on various
green synthetic procedures reported for quinoxalines along with the specializations and applications of the
reactions.
Análisis cualitativo y dimensionamiento del impacto ambiental del uso de la Energía Fotovoltaica: 3 Casos de estudio en el Perú
Authors: Sánchez Talledo Dairo Alejandro , Paragua Macuri Carlos Alberto , Paragua Morales Melecio , Paragua Macuri Melissa Gabriela 
Published: July 2023

El objetivo del presente trabajo es analizar y dimensionar el impacto ambiental del ciclo de vida del uso de la energía fotovoltaica a través de tres sistemas fotovoltaicos policristalinos ya existentes en el Perú. Para ello, se realizó un balance energético o energy payback time (EPBT) y un dimensionamiento de la huella de carbono que produce cada sistema en su tiempo de vida. En el análisis, se consideró la etapa de fabricación, transporte, instalación y desinstalación de los paneles solares; asimismo, la fabricación de los componentes del Balance del Sistema (BOS) que aportan significativamente en el ciclo de vida de los paneles solares.
El primer caso es un grupo de 5 viviendas rurales en Puno que consumen 10 kWh/día, el segundo caso es el sistema fotovoltaico que se encuentra instalado en el techo del Instituto de Ingenieros de Minas del Perú que tiene una capacidad de 20.8 kWp y, el tercer caso es la Central Solar Rubí ubicada en Moquegua, la cual tiene una capacidad de 179.5 MWp. Se obtuvo en los resultados que el EPBT para cada caso es de 4.68, 6.42 y 3.64 años, respectivamente. Del mismo modo, que la huella de carbono que produjeron los sistemas fotovoltaicos fue de 11 tCO2eq, 71.41 tCO2eq y 0.57 MtCO2eq, respectivamente, mediante una herramienta de cálculo propia.
Gamification and Soft Skills Assessment in the Development of a Serious Game: Design and Feasibility Pilot Study
Authors: Altomari Luca , Altomari Natalia , Iazzolino Gianpaolo 
Published: July 2023

Background
The advent of new technologies has had a profound impact on the labor market, transforming the way we work and interact with each other. With the rise of digital tools and platforms, gamification has emerged as a powerful technique for enhancing productivity and engagement in various fields, including human resource management. In particular, gamification has been found to be effective in developing and assessing soft skills, which play a critical role in determining the success of individuals, teams, and organizations.

Objective
We present a serious game that identifies the most sought-after skills in the job market and offers feedback, and we provide a set of guidelines for the creation of serious games.

Methods
We present the serious game Among the Office Criticality (AOC). The AOC game structure involves a set of sequence analysis techniques, which is known as process mining.

Results
The pilot study findings indicate that the game is both engaging and beneficial to subjects, suggesting that the results align with current theoretical perspectives. Furthermore, the study suggests that the obtained data can be extended to the broader population.

Conclusions
This study illustrates a serious game structured according to the needs of the labor market and developed to put the user at the center, using evaluation techniques consistent with the literature, with the aim of constituting an interdisciplinary approach suitable for adequately assessing users and creating value for them.
Penerapan Model Problem Based Learning Untuk Meningkatkan Hasil Belajar IPA Siswa MTs Ma’arif Bakalan
Authors: Khasanah Uswatun , Fatkhurrohman Fatkhurrohman , Fatiatun Fatiatun 
Published: July 2023

Latar belakang dalam penelitian ini ada pada pembelajaran IPA di kelas VII MTs Ma’arif Bakalan yang masih menerapkan pendekatan Teacher Centered Learning (TCL). Tujuan dari penelitian ini antara lain: (1) Untuk mengetahui penerapan model problem based learning dalam pembelajaran IPA siswa kelas VII MTs Ma’arif Bakalan. (2) Untuk mengetahui peningkatan hasil belajar IPA setelah diterapkannya model problem based learning pada siswa kelas VII MTs Ma’arif Bakalan. (3) Untuk mengetahui perbedaan hasil belajar IPA antara kelas yang menggunakan model problem based learning dengan kelas yang tidak menggunakan model problem based learning pada siswa kelas VII MTs Ma’arif Bakalan. Metode yang diterapkan pada penelitian ini ialah metode eksperimen melalui model quasi eksperiment serta desain non equivalent control group. Populasi yang dipilih ialah siswa kelas VII. Sampel yang diambil yaitu kelas VII A dengan total 20 siswa serta VII B dengan total 20 siswa. Hasil Penelitian menunjukan bahwa berdasarkan hasil posttest menggunakan uji N-Gain kelas eksperimen meningkat sebanyak 0,57 dan kelas kontrol didapat N-Gain sebanyak 0,23. Dengan ini telah terbukti adanya kenaikan hasil belajar IPA kelas eksperimen dengan menerapkan model problem based learning dengan kategori sedang. Terdapat selisih perbedaan antara hasil belajar IPA kelas dengan model problem based learning dan kelas tidak dengan model problem based learning. Terbukti dengan menggunakan uji-t yaitu Ho ditolak yang ditunjukkan dengan perolehan thitung = 4,69 > ttabel = 2,02 dengan taraf signifikan 5% dan thitung = 4,69 > ttabel = 2,71 dengan taraf signifikan 1% sehingga Ha diterima. Dari data tersebut bisa ditarik kesimpulan bahwasanya penerapan model PBL bisa meningkatkan hasil belajar IPA siswa kelas VII di MTs Ma’arif Bakalan tahun pelajaran 2022/2023.
ANALISIS KEMAMPUAN BERPIKIR LOGIS SISWA KELAS VIII MELALUI PERCOBAAN SEDERHANA PADA PELAJARAN IPA
Authors: Arifiya Nur 
Published: July 2023

Penelitian ini bertujuan untuk menganalisis kemampuan berfikir logis siswa untuk mencari sebab akibat dan menemukan benang merah dari percobaan sederhana yang telah dilakukan. Aktivitas siswa dalam berpikir logis yaitu berusaha menjelaskan apa yang telah diperoleh dan melatih siswa untuk melakukan aktifitas yang lebih luas dalam menarik kesimpulannya. Penelitian ini menggunakan metode penelitian kualitatif yang menghasilkan data deskriptif berupa kata-kata. Penelitian dilakukan di SMP Islam Bojonggede Bogor, peserta didik kelas VIII berjumlah 12 orang siswa. Peserta didik diberikan tugas percobaan sederhana untuk materi gelombang dan bunyi dengan menggunakan alat yang sederhana, percobaan ini dilakukan secara individu serta dibuat laporan tertulis masing-masing siswa dan secara kelompok dalam presentasinya. Berdasarkan hasil penelitian ini terlihat bahwa subjek yangmemiliki kemampuan lebih baik, jika focus dan motivasinya baik. Maka akan menghasilkan berpikir logis yang baik pula, namun jika kurang focus dan motivasinya tidak maksimal, maka kemampuan berpikir logisnya akan lebih rendah dengan subjek yang memiliki kemampuan dasarnya di bawah subjek tersebut.
PERKEMBANGAN KOREAN CULTURE DI KOTA JAMBI MASA REFORMASI (2000-2021)
Authors: Al-Habro Akil , Alvian Ali Nur , Seprina Reka 
Published: July 2023

Rumusan masalah dalam penelitian Perkembangan Korean Culture di Kota Jambi ini adalah Bagaimana Perkembangan Korean Culture Di Kota Jambi Masa Reformasi (2000-2021)”. Penelitian ini bertujuan untuk mendeskripsikan Perkembangan Korean Culture di Kota Jambi Masa Reformasi (2000-2021). Penelitian ini tergolong dalam penelitian Kualitatif dengan pendekatan histories. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang melalui beberapa tahap yaitu: heuristik, kritik sumber, interpretasi dan historiografi. Hasil penelitian menunjukkan bahwa Korean Culture telah suskes berkembang di jambi sejak dimulainya Korean Wave yang masuk ke Indonesia yang kemudia menyebar keseluruh Indonesia termasuk jambi. Masuknya budaya Korea di Kota Jambi dengan pengenalan K-Drama ke Indonesia. Korean Wave dapat diterima oleh sebagian besar masyarakat Jambi, berhasil dengan K-Drama, memberi jalan terhadap berbagai produk-produk Korea lainnya seperti K-Pop, K-Food, K-Style, Bahasa Korea, Teknologi Korea.
MASALAH SOSIAL DAN SOLUSI DALAM MENGHADAPI FENOMENA STUNTING PADA ANAK
Authors: Rumlah Siti 
Published: July 2023

Indonesia memiliki persoalan gizi yang relatif berat yg ditandai dengan banyaknya masalah gizi kurang. Malnutrisi ialah suatu akibat keadaan status gizi. Stunting ialah salah satu keadaan malnutrisi yg berkaitan dengan ketidakcukupan zat gizi masa lalu sebagai akibatnya termasuk dalam problem gizi yang bersifat kronis. hegemoni yg paling menentukan untuk bisa mengurangi pervalensi stunting oleh karena itu perlu dilakukan di 1.000 Hari Pertama Kehidupan (HPK) dari anak balita. Pencegahan stunting bisa dilakukan diantaranya menggunakan cara 1. Pemenuhan kebutuhan zat gizi bagi bunda hamil. 2. ASI eksklusif hingga umur 6 bulan serta sesudah umur 6 bulan diberi kuliner pendamping ASI (MPASI) yang cukup jumlah serta kualitasnya. 3. Memantau pertumbuhan balita di posyandu. 4. menaikkan akses terhadap air bersih serta fasilitas sanitasi, dan menjaga kebersihan lingkungan.
O roleplaying game (RPG) como ferramenta dialógica para a promoção dos letramentos digital e literário
Authors: Botelho Marina Alvarenga , Dias Fábio Luiz de Castro , Petronilho Caio Gutemberg da Silva 
Published: July 2023

O advento, no decorrer das últimas três décadas, das novas tecnologias de informação e comunicação levou a humanidade a sofrer mudanças drásticas em seu cotidiano, principalmente no que diz respeito às práticas letradas. Novas formas de letramento, que compõem o incontestável vernáculo multimodal (DALEY, 2010) da atualidade, composto por formas sígnicas vinculadas a gêneros discursivos inovadores que, em telas de diversos tipos e tamanhos, mesclam voz, escrita, imagem, música e vídeo, impulsionaram discussões que buscaram reinventar a acepção científica desse fenômeno, bem como o tratamento pedagógico das atividades sociais que dependem da língua escrita. Tendo em vista essa necessidade de reconfiguração da prática docente com vistas a acompanhar a imposição de um novo paradigma semiótico, este trabalho propõe o uso do roleplaying game (RPG), ou, em tradução literal, jogo de interpretação de papéis, como ferramenta dialógica que permite, entre outras possibilidades, a promoção dos letramentos digital e literário em sala de aula, pois se configura como um recurso lúdico. Para isso, discute-se a ideia de letramento, que hoje é comumente entendida por intermédio do conceito de multiletramentos, bem como se recorre a discussões específicas sobre o letramento literário e sobre o letramento digital. Em adição, fala-se sobre o que é o RPG, por meio de um breve histórico e da apresentação de suas principais características, e propõe-se o uso do mRPG, software que permite a criação personalizada de universos de RPG, apresentando-se um roteiro para seu uso e sugestões de tratamento de temas referentes à literatura com base nessa plataforma.
Analysis of Bottom-Hole Temperature and Preliminary Estimation Of Heat Flow in Portuguese Sedimentary Basins
Authors: Camelo Susana Maria Lasbarrares 
Published: July 2023

Determination of the geothermal gradient and heat flow from bottom temperatures (BHT) were measured for wells in the Portuguese offshore and onshore (Algarve and Lusitanian Basins). The temperature BHT's are corrected by empirical relations with available data, but in cases where multiple BHT's are measured at the same depth at successive times the method developed by Dowdle & Cobb (1975) is used. The general least square inversion theory is applied to the estimation of heat flow and its uncertainty, Vasseur & Lucazeau (1985). Estimates for heat flow density in the Lusitanian Basin are around 80 mWm-2, but values up to 106 mWm-2 occur where salt diapirs occur. Geothermal gradients range from 21.6 to 35.5°C/km, with an average of 27.7°C/km. One value for the Algarve Basin showed lower heat flow density. Os gradientes geotérmicos e o fluxo de calor a partir de temperatura de fundo de poço (BHT) foram obtidos para poços terrestres e marinhos da costa portuguesa (Bacias de Algarve e Lusitana).As temperaturas de fundo de poço (BHT) foram corrigidas através de relações empíricas obtidas a partir dos dados observados, mas em casos em que múltiplas BHT na mesma profundidade e para tempos diferentes eram disponíveis, o método desenvolvido por Dowdle & Cobb (1975) foi utilizado. A teoria de inversão generalizada por mínimos quadrados foi utilizada para estimar o fluxo térmico e sua respectiva incerteza (Vasseur & Lucazeau, 1985). As estimativas de densidade de fluxo térmico na Bacia Lusitana são de aproximadamente 80 mWm-2, mas valores de até 106 mWm-2 são observados onde ocorrem diapiros de sal. Os gradientes geotérmicos variam de 21,6 a 35,5°C/km, com um valor médio de 27,7°C/km. Um único valor para a Bacia do Algarve sugere um valor de densidade de fluxo térmico inferior.