bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in best‐case, typical and worst‐case survival scenarios of patients with non‐metastatic esophagogastric cancer between 2006 and 2020: A population‐based study
Authors: Kuijper Steven C. , Pape Marieke , Vissers Pauline A. J. , Jeene Paul M. , Kouwenhoven Ewout A. , Haj Mohammad Nadia , Ruurda Jelle P. , Sosef Meindert N. , Verhoeven Rob H. A. , van Laarhoven Hanneke W. M. 
Published: March 2023

AbstractNew treatment options and centralization of surgery have improved survival for patients with non‐metastatic esophageal or gastric cancer. It is unknown, however, which patients benefitted the most from treatment advances. The aim of this study was to identify best‐case, typical and worst‐case scenarios in terms of survival time, and to assess if survival associated with these scenarios changed over time. Patients with non‐metastatic potentially resectable esophageal or gastric cancer diagnosed between 2006 and 2020 were selected from the Netherlands Cancer Registry. Best‐case (20th percentile), upper‐typical (40th percentile), typical (median), lower‐typical (60th percentile) and worst‐case (80th percentile) survival scenarios were defined, and regression analysis was used to investigate the change in survival time for each scenario across years. For patients with esophageal cancer (N = 24 352) survival time improved on average 12.0 (until 2011), 1.5 (until 2018), 0.7, 0.4 and 0.2 months per year for the best‐case, upper‐typical, median, lower‐typical and worst‐case scenario, respectively. For patients with gastric cancer (N = 9993) survival time of the best‐case scenario remained constant, whereas the upper‐typical, median, lower‐typical and worst‐case scenario improved on average with 1.0 (until 2018), 0.5, 0.2 and 0.2 months per year, respectively. Subgroup analyses showed that, survival scenarios improved for nearly all patients across treatment groups and for patients with squamous cell carcinomas or adenocarcinomas. Survival improved for almost all patients suggesting that in clinical practice the vast majority of patients benefitted from treatment advances. The clinically most meaningful survival advantage was observed for the best‐case scenario of esophageal cancer.
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A
Authors: Taylor Susan S. , Herberg Friedrich W , Veglia Gianluigi , Wu Jian 
Published: March 2023

AbstractAlthough Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co‐discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP‐dependent protein kinase (PKA), but also by the heat‐stable, high‐affinity protein kinase inhibitor (PKI). PKI is an intrinsically disordered protein that contains at its N‐terminus a pseudo‐substrate motif that binds synergistically and with high‐affinity to the PKA catalytic (C) subunit. The sequencing and characterization of this inhibitor peptide (IP20) were validated by the structure of the PKA C‐subunit solved first as a binary complex with IP20 and then as a ternary complex with ATP and two magnesium ions. A second motif, nuclear export signal (NES), was later discovered in PKI. Both motifs correspond to amphipathic helices that convey high‐affinity binding. The dynamic features of full‐length PKI, recently captured by NMR, confirmed that the IP20 motif becomes dynamically and sequentially ordered only in the presence of the C‐subunit. The type I PKA regulatory (R) subunits also contain a pseudo‐substrate ATPMg2‐dependent high‐affinity inhibitor sequence. PKI and PKA, especially the Cβ subunit, are highly expressed in the brain, and PKI expression is also cell cycle‐dependent. In addition, PKI is now linked to several cancers. The full biological importance of PKI and PKA signaling in the brain, and their importance in cancer thus remains to be elucidated.
Elabela‐apelin‐12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1‐P2X7 signaling pathway
Authors: Chen Zhe , Luo Xuling , Liu Meiqing , Jiang Jinyong , Li Yao , Huang Zhen , Wang Lingzhi , Cao Jiangang , He Lu , Huang Shifang , Hu Haoliang , Li Lanfang , Chen Linxi 
Published: March 2023

AbstractThe elabela‐apelin/angiotensin domain type 1 receptor‐associated protein (APJ) system is an important regulator in certain thrombosis‐related diseases such as atherosclerosis, myocardial infarction, and cerebral infarction. Our previous reports have revealed that apelin exacerbates atherosclerotic lesions. However, the relationship between the elabela‐apelin/APJ system and platelet aggregation and atherothrombosis is unclear. The results of the present study demonstrate that elabela and other endogenous ligands such as apelin‐12, ‐17, and ‐36 induce platelet aggregation and thrombosis by activating the pannexin1(PANX1)‐P2X7 signaling pathway. Interestingly, the diuretic, spironolactone, a novel PANX1 inhibitor, alleviated elabela‐ and apelin isoforms‐induced platelet aggregation and thrombosis. Significantly, two potential antithrombotic drugs were screened out by targeting APJ receptors, including the anti‐HIV ancillary drug cobicistat and the traditional Chinese medicine monomer Schisandrin A. Both cobicistat and Schisandrin A abolished the effects of elabela and apelin isoforms on platelet aggregation, thrombosis, and cerebral infarction. In addition, cobicistat significantly attenuated thrombosis in a ponatinib‐induced zebrafish trunk model. Overall, the elabela–apelin/APJ axis mediated platelet aggregation and thrombosis via the PANX1‐P2X7 signaling pathway in vitro and in vivo. Blocking the APJ receptor with cobicistat/Schisandrin A or inhibiting PANX1 with spironolactone may provide novel therapeutic strategies against thrombosis.
EPISOL: A software package with expanded functions to perform 3D‐RISM calculations for the solvation of chemical and biological molecules
Authors: Cao Siqin , Kalin Michael L. , Huang Xuhui 
Published: March 2023

AbstractIntegral equation theory (IET) provides an effective solvation model for chemical and biological systems that balances computational efficiency and accuracy. We present a new software package, the expanded package for IET‐based solvation (EPISOL), that performs 3D‐reference interaction site model (3D‐RISM) calculations to obtain the solvation structure and free energies of solute molecules in different solvents. In EPISOL, we have implemented 22 different closures, multiple free energy functionals, and new variations of 3D‐RISM theory, including the recent hydrophobicity‐induced density inhomogeneity (HI) theory for hydrophobic solutes and ion‐dipole correction (IDC) theory for negatively charged solutes. To speed up the convergence and enhance the stability of the self‐consistent iterations, we have introduced several numerical schemes in EPISOL, including a newly developed dynamic mixing approach. We show that these schemes have significantly reduced the failure rate of 3D‐RISM calculations compared to AMBER‐RISM software. EPISOL consists of both a user‐friendly graphic interface and a kernel library that allows users to call its routines and adapt them to other programs. EPISOL is compatible with the force‐field and coordinate files from both AMBER and GROMACS simulation packages. Moreover, EPISOL is equipped with an internal memory control to efficiently manage the use of physical memory, making it suitable for performing calculations on large biomolecules. We demonstrate that EPISOL can efficiently and accurately calculate solvation density distributions around various solute molecules (including a protein chaperone consisting of 120,715 atoms) and obtain solvent free energy for a wide range of organic compounds. We expect that EPISOL can be widely applied as a solvation model for chemical and biological systems. EPISOL is available at https://github.com/EPISOLrelease/EPISOL.
Characterization of eyes, photoreceptors, and opsins in developmental stages of the arrow wormSpadella cephaloptera(Chaetognatha)
Authors: Wollesen Tim , Rodriguez Monje Sonia V. , Oel Adam P. , Arendt Detlev 
Published: March 2023

AbstractThe phylogenetic position of chaetognaths, or arrow worms, has been debated for decades, however recently they have been grouped into the Gnathifera, a sister clade to all other Spiralia. Chaetognath photoreceptor cells are anatomically unique by exhibiting a highly modified cilium and are arranged differently in the eyes of the various species. Studies investigating eye development and underlying gene regulatory networks are so far missing. To gain insights into the development and the molecular toolkit of chaetognath photoreceptors and eyes a new transcriptome of the epibenthic speciesSpadella cephalopterawas searched for opsins. Our screen revealed two copies ofxenopsinand a single copy ofperopsin. Gene expression analyses demonstrated that onlyxenopsin1is expressed in photoreceptor cells of the developing lateral eyes. Adults likewise exhibit twoxenopsin1 + photoreceptor cells in each of their lateral eyes. Beyond that, a singlecryptochromegene was uncovered and found to be expressed in photoreceptor cells of the lateral developing eye. In addition,cryptochromeis also expressed in the cerebral ganglia in a region in which alsoperopsinexpression was observed. This condition is reminiscent of a nonvisual photoreceptive zone in the apical nervous system of the annelidPlatynereis dumeriliithat performs circadian entrainment and melatonin release.Cryptochromeis also expressed in cells of the corona ciliata, an organ in the posterior dorsal head region, indicating a role in circadian entrainment. Our study highlights the importance of the Gnathifera for unraveling the evolution of photoreceptors and eyes in Spiralia and Bilateria.
Automatic design of microwave filters by using relational induction neural networks
Authors: Dai Xi Wang , Hu Wen Hao , Fu Yang Hui , Liu Jie , Chen Zhi Xi 
Published: March 2023

AbstractAutomatic design of microwave filter based on artificial intelligence is recognized as an alternative to conventional approach, due to the complexity of the structure parameters and the need of enormous solution space. In this paper, an unsupervised, end‐to‐end training framework, which is named Relational Induction Neural Network (RINN) is proposed. RINN discretizes the model, and makes cluster analysis on each action of geometrical parameters. Deep reinforcement learning (DRL) neural network is applied to design the filter according to reward function. Several second‐order filters with different performance and one sixth‐order filter are designed with RINN. The results show that RINN can automatically induce the relationship between microwave device structures without any prior knowledge through training or learning. This research crosses the gap between DRL and microwave filter, and can also be extended to other microwave device, antenna and other related fields.
Congenital Malformations of the Cricoid Cartilage: Upper Airway Obstruction and Treatment Strategy
Authors: Gombert Edwige , Gorostidi Francois , Sandu Kishore 
Published: March 2023

ObjectivesTo review treatment and outcomes in patients with congenital cricoid cartilage malformation.MethodsRetrospective analysis of patients with diagnosis of congenital cricoid malformation (CCM) treated in a single tertiary pediatric referral center between 1985 and 2022. Patients were grouped according to the morphology of the cricoid cartilage that was diagnosed during endoscopy. We reviewed the treatment strategy(s), decannulation rate, complications, and functional outcomes.ResultsTwenty‐nine patients were grouped into four morphological subtypes of cricoid cartilage: 10 patients had a hypoplastic cricoid, eight had an elliptic shape, five had severe anterior thickening, and six an accentuated V‐shape posterior cricoid plate. Twenty‐four patients underwent surgery, and five were closely followed up without surgical treatment. Eight patients had a tracheostomy prior to surgery, and the majority had a hypoplastic cricoid. Most patients (20 out of 24) required additional procedures postoperatively to achieve an age‐appropriate airway. Thirteen patients needed endoscopic dilatation(s) and granulation tissue removal; four needed more aggressive treatment, and three patients required revision open surgery. Decannulation was achieved after a median of 4.5 months in all previously tracheostomized patients. Endoscopy at the last follow‐up showed an age‐appropriate airway in 27 patients; 20 patients had normal oral feeding, and 11 patients had a normal voice.ConclusionEndoscopy is important to diagnose CCM and most of the time patients would need only watchful waiting. In this report, surgery was required for patients who continued to remain symptomatic and had a compromised airway. The type of surgery depends on the type of cricoid malformation and the grade of stenosis.Level of Evidence4 Laryngoscope, 133:3185–3191, 2023
Crop residue return and nitrogen fertilizer reduction alleviate soil acidification in China's croplands
Authors: Zuo Wengang , Yi Siqiang , Gu Binxian , Zhou Yuxi , Qin Tianyang , Li Yunlong , Shan Yuhua , Gu Chuanhui , Bai Yanchao 
Published: March 2023

AbstractAccurate knowledge of the soil pH in China's croplands is essential to control soil acidification and improve soil quality and sustainability of agricultural systems. Here, this study analyzed the soil pH in China's croplands and its change based on a comprehensive investigation of 8.9 million soil samples from 2534 counties. We show that China's croplands were mainly composed of weakly acidic soils (34.9%) and alkaline soils (35.3%), and the mean soil pH (0–20 cm) was 6.74–6.83 in 2010 at the national scale. Weakened acidification was observed in China's cropland soils with 0.11 units during 1980–2010. Soil acidification occurred mainly in southern, eastern, and northeastern provinces, especially in Liaoning, Hainan, Jilin, and Heilongjiang. The changes in soil pH in China's croplands during 1980–2010 were driven by initial soil pH, mean annual precipitation, crop biomass removal, and nitrogen fertilizer input, with the latter two explaining 20.9% of the total variation. Given this, four scenarios with different crop residue and nitrogen fertilizer inputs were designed to assess soil pH changes in China's croplands during 2020–2050. The results show that soil acidification will continue under existing agricultural production practices. Increasing crop residue input and reducing nitrogen fertilizer input can effectively alleviate soil acidification and even increase soil pH over the next 30 years. We also proposed targeted fertilization and crop residue returning strategies to further alleviate soil acidification in different provinces by considering current agricultural management practices.
Decoupling and partitioning the effect of climate and afforestation on long‐term vegetation greening in China since the 1990s
Authors: Li Peng , Tiantian Chen , Yuxi Wang , Qiang Wang 
Published: March 2023

AbstractVegetation is an essential component of the Earth's surface system, and is a clear indicator to global climate changes. Understanding the long‐term characteristics of vegetation variations and their relationship to climate and human activities is important for regional sustainable development and ecological construction. In this study the ensemble empirical mode decomposition, the breaks for additive seasonal and trend algorithm and trend analysis were applied to obtain the spatiotemporal characteristics of the long‐term interannual normalized difference vegetation index in China. Partial least squares‐structural equation modeling and geographically weighted regression were used to separate the effects of climate and human activities on vegetation greening and achieve the partitioning of these driving forces. The results suggested that vegetation growth in China experienced an abrupt change in 1995, there was obvious vegetation ‘browning’ during 1990–1995, and noticeable vegetation recovery from 1996 to 2018 (slope = 0.129/yr, p = 0.009). Spatially, vegetation ‘greening’ was occurred in central and southern China, reflecting the positive effect of ecological restoration projects on vegetation growth. Climate was a directly main driving force for vegetation greening in China. It played a positive role in South China, but had a negative effect in Northwest China. Improving socio‐economic conditions had a slightly negative impact on vegetation greening, while afforestation played a direct and obvious role in promoting vegetation growth, especially in Northwest China. Furthermore, afforestation and socio‐economic conditions would also indirectly affect vegetation growth by directly influencing the local microclimate, and the indirect effect of them on vegetation growth was far greater than its direct impact in some cases; therefore, research attention should be paid to the indirect effects of these driving forces on vegetation growth. There was obvious spatial heterogeneity in the effects of different forces on vegetation greening in China, and the dominant driving force of vegetation change in each geographical region also differed.
Changes in soil and litter properties differentially influence soil nematode communities across three successional stages in two contrasting forests
Authors: Wang Mengmeng , Yu Binbin , Shen Zhifeng , Zhao Lina , Zhang Jie , Cui Yang , Fan Zongji , Zu Weizhong , Dai Guanhua , Zhang Weixin , Fu Shenglei , Shao Yuanhu 
Published: March 2023

AbstractUnderstanding the linkages between aboveground and belowground ecosystems is important for explaining the variation in soil organisms with plant communities on a spatiotemporal scale. Here, soil nematode communities were investigated across three successional stages (early, mid, and late) in two contrasting forests at low and high latitudes in China. We found that forest succession affected the relative abundance of some nematode trophic groups, whereas it did not alter the total nematode abundance in the two forests. Nonmetric multidimensional scaling analysis showed that nematode community composition changed significantly from the early and mid‐stages to the late stage. The mantel analysis showed that total soil P at low latitude and litter C:N ratio at high latitude were more closely related to the variation in nematode community during forest succession, respectively. Total nematode diversity increased marginally with forest succession at low latitude, but first increased and then decreased with forest succession at high latitude. Interestingly, total nematode diversity was related to plant‐feeding nematode diversity during forest succession in both the forests. In addition, structural equation models showed that the diversity of different nematode trophic groups was directly affected by forest succession and indirectly affected by the quantity of soil resources and the quality of soil and litter. More importantly, forest succession drives total nematode diversity by directly affecting plant‐feeding nematode diversity. Collectively, forest succession alters the diversity and increases the dissimilarity of soil nematode communities. However, changes in soil and litter properties during forest succession at different latitudes differentially influence nematode communities.
Biochemical composition, bioactivity, processing, and food applications of winged bean (Psophocarpus tetragonolobus): A review
Authors: Bepary Rejaul Hoque , Roy Arnab , Pathak Khanin , Deka Sankar Chandra 
Published: March 2023

AbstractThe winged bean, Psophocarpus tetragonolobus (L.) D.C., is called the four‐angled bean or Goa bean, which is an underutilized, non‐conventional, and multipurpose tropical legume cultivated in Southeast Asia and Papua New Guinea. The objective of this article was to reveal a comprehensive view on the nutritional properties, biochemical compositions, health benefits, processing, and food applications of winged beans. The average moisture, carbohydrate, protein, fat, crude fiber, and ash content of 138 genotypes of winged bean seeds were found as 9.09 ± 1.73%, 26.81 ± 6.88%, 34.98 ± 4.63%, 18.01 ± 2.27%, 10.24 ± 5.49%, and 4.16 ± 0.41%, respectively. Leaves of winged beans are good sources of vitamins such as vitamin C (14.5–128 mg/100 g), thiamine, riboflavin, niacin, vitamin B6, folate, vitamin A (5240–20,800 IU), and vitamin E. The seed of winged beans is rich in calcium, iron, phosphorus, zinc, and copper. The anti‐nutritional factors, namely, trypsin inhibitor, chymotrypsin inhibitor, phytic acid, saponin, tannin, oxalate, and flatulence saccharides of winged bean, were reported to be in the range of 40–99.5 TIU/mg of protein, 86.4–109.6 CIU/mg of protein, 4.09%–9.96%, 0.6%, 0.77%–0.97%, 0.5%, and 0.04%–0.18%, respectively. This bean can prevent diabetes, cancer, and asthma, boost immunity, and promote women's and men's reproductive health. Winged are transformed into consumable form by processing methods such as soaking, cooking, sprouting, fermentation, roasting, and so forth. This bean is processed into traditional products (curries, soup, pickles, etc.) and contemporary products (milk, tofu, tempeh, etc.). Future research should focus on promoting its utilization as an alternative to soybeans toward meeting global food and nutritional security.
The proximal self: Why material objects are particularly relevant for consumers' self‐definition
Authors: Scharfenberger Philipp , Wentzel Daniel , Warlop Luk , Riegler Verena 
Published: March 2023

AbstractPrevious research has extensively investigated the relationships that consumers create and maintain with their possessions. However, little is known about why material objects (compared to immaterial ones) may be particularly relevant for consumers' self‐definition. In this research, we argue that being physically close to objects helps consumers to feel psychologically close to the more abstract meaning of these objects. Four experimental studies provide converging support for this reasoning. Specifically, these studies indicate that being proximal to an object reduces the psychological distance to the object's meaning and enhances the benefits that consumers associate with the object. Moreover, the effect of bodily proximity on perceived benefits is moderated by separation anxiety, such that consumers that are highly anxious about being separated from the object's meaning derive higher benefits from being proximal to it. The findings contribute to research on the extended self and highlight the potential importance of physical proximity as a motivational driver of consumer behavior.
Partially observable corporate social responsibility: The limits of differentiation
Authors: Calveras Aleix , Sákovics József 
Published: March 2023

AbstractWe investigate investment incentives in credence corporate social responsibility under different market structures. In duopoly, for high enough investment transparency (IT), exactly one firm invests in the clean technology: They differentiate their products. If the firms merge, with high enough IT and product traceability, the monopolist also invests in (only) one plant, but the necessary IT for investment is higher. Without product traceability, whenever the monopolist invests, it is in both plants, but the IT required for investment is even higher. We conclude that “green” competition policy must be nuanced, taking into account (or regulating) both transparency and traceability.