bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work–Family Conflict: Understanding Workplace Relationships for Collegiate Athletic Trainers
Authors: Singe Stephanie M. , Tannebaum Chloe , Cairns Alexandrya H. 
Published: April 2023

Role congruence has been suggested to be a facilitator for work–life balance for the athletic trainer, but to date, it has only been superficially explored. Conceptually, role congruence is based on relationships and roles within the organization; thus, the purpose of the study was to further investigate professional relationships between coaches and athletic trainers related to work–life balance. To accomplish this, 28 credentialed athletic trainers were interviewed via the Zoom platform. Three identifiable themes were found within the data. The first them role congruence reduces stress for the athletic trainer and was supported by two themes: (a) role congruence facilitates a positive work environment and (b) incongruence facilitates a stressful work environment. The second theme, peak season expectations and job demands limit work–life balance, was defined by (a) hours worked, (b) coaches’ expectations, and (c) sport is demanding, which impacts work–life balance.
Hemagglutinin destabilization in H3N2 vaccine reference viruses skews antigenicity and prevents airborne transmission in ferrets
Authors: Hu Meng , Kackos Christina , Banoth Balaji , Ojha Chet Raj , Jones Jeremy C. , Lei Shaohua , Li Lei , Kercher Lisa , Webby Richard J. , Russell Charles J. 
Published: April 2023

During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes membrane fusion after endosomal acid activation. To improve vaccine efficiency and pandemic risk assessment for currently-dominant H3N2 influenza viruses, we investigated HA stability of 6 vaccine reference viruses and 42 circulating viruses. Recent vaccine reference viruses had destabilized HA proteins due to egg-adaptive mutation HA1-L194P. Virus growth in cell culture was independent of HA stability. In ferrets, the vaccine reference viruses and circulating viruses required a relatively stable HA (activation and inactivation pH < 5.5) for airborne transmissibility. The recent vaccine reference viruses with destabilized HA proteins had reduced infectivity, had no airborne transmissibility unless reversion to HA1-P194L occurred, and had skewed antigenicity away from the studied viruses and circulating H3N2 viruses. Other vaccine reference viruses with stabilized HAs retained infectivity, transmissibility, and antigenicity. Therefore, HA stabilization should be prioritized over destabilization in vaccine reference virus selection to reduce mismatches between vaccine and circulating viruses.
Determinants of recreational screen time behavior following the COVID-19 pandemic among Canadian adults
Authors: Liu Sam , Coulter Rebecca , Sui Wuyou , Nuss Kayla , Rhodes Ryan E. 
Published: April 2023

The objectives of our study were to examine recreational screen time behavior before and 2 years following the COVID-19 pandemic lockdown, and explore whether components of the capability–opportunity–motivation–behavior (COM-B) model would predict changes in this recreational screen time behavior profile over the 2-year period. This cross-sectional, retrospective study was conducted in March 2022. Canadian adults ( n = 977) completed an online survey that collected demographic information, current screen time behavior, screen time behavior prior to the pandemic, and beliefs about capability, opportunities, and motivation for limiting screen time based on the COM-B model. We found that post-pandemic recreational screen time (3.91 ± 2.85 h/day) was significantly higher than pre-pandemic levels (3.47 ± 2.50 h/day, p < 0.01). Three recreational screen time behavior profiles were identified based on the Canadian 24-Hour Movement Guidelines: (1) always met screen time guidelines (≤3 h/day) (47.8%; n = 454); (2) increased screen time (10.1%; n = 96); and (3) never met screen time guidelines (42%; n = 399). The overall discriminant function was found to be significant among the groups (Wilks’ λ = 0.90; canonical r = 0.31, χ2 = (14) = 95.81, p < 0.001). The group that always met screen time guidelines had the highest levels of automatic motivation, reflective motivation, social opportunity, and psychological capabilities to limit screen time compared to other screen time profile groups. In conclusion, recreational screen time remains elevated post-pandemic. Addressing motivation (automatic and reflective), psychological capabilities, and social opportunities may be critical for future interventions aiming to limit recreational screen time.
Abnormal Traffic Detection Method of Internet of Things Based on Deep Learning in Edge Computing Environment
Authors: Qiu Lingcong , Wang Lei 
Published: April 2023

In this paper, a method based on deep learning to detect abnormal traffic of IoTs in edge computing environment is proposed. Firstly, the data are preprocessed by data cleaning, normalization, oversampling and undersampling, and data set segmentation to obtain a data set with balanced data distribution. Secondly, a method of calculating feature information based on data increment is adopted, which can accurately extract feature information from the dynamic data flow. Finally, the convolution neural network (CNN) is used to extract the local features of the data, and the bi-directional gated loop unit (BiGRU) is used to extract the long sequence correlation of the data. The two networks work together to extract data features. The self-focus mechanism is introduced to deal with redundant data. Experiments show that the accuracy, recall and [Formula: see text]1 value of the proposed method are 97.36%, 98.38% and 97.16%, respectively, in the normal class, which are higher than the comparison algorithm.
Optimization-Aware Compiler-Level Event Profiling
Authors: Basso Matteo , Prokopec Aleksandar , Rosà Andrea , Binder Walter 
Published: April 2023

Tracking specific events in a program’s execution, such as object allocation or lock acquisition, is at the heart of dynamic analysis. Despite the apparent simplicity of this task, quantifying these events is challenging due to the presence of compiler optimizations. Profiling perturbs the optimizations that the compiler would normally do—a profiled program usually behaves differently than the original one.In this article, we propose a novel technique for quantifying compiler-internal events in the optimized code, reducing the profiling perturbation on compiler optimizations. Our technique achieves this by instrumenting the program from within the compiler, and by delaying the instrumentation until the point in the compilation pipeline after which no subsequent optimizations can remove the events. We propose two different implementation strategies of our technique based on path-profiling, and a modification to the standard path-profiling algorithm that facilitates the use of the proposed strategies in a modernjust-in-time (JIT)compiler. We use our technique to analyze the behaviour of the optimizations in Graal, a state-of-the-art compiler for the Java Virtual Machine, identifying the reasons behind a performance improvement of a specific optimization, and the causes behind an unexpected slowdown of another. Finally, our evaluation results show that the two proposed implementations result in a significantly lower execution-time overhead w.r.t. a naive implementation.
PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis
Authors: Moyo Tamara K. , Kishtagari Ashwin , Villaume Matthew T. , McMahon Brandon , Mohan Sanjay R. , Stopczynski Tess , Chen Sheau-Chiann , Fan Run , Huo Yuankai , Moon Hyeonsoo , Tang Yucheng , Bejan Cosmin A. , Childress Merrida , Anderson Ingrid , Rawling Kyle , Simons Rhea M. , Moncrief Ashley , Caza Rebekah , Dugger Laura , Collins Aunshka , Dudley Channing V. , Ferrell P. Brent , Byrne Michael , Strickland Stephen A. , Ayers Gregory D. , Landman Bennett A. , Mason Emily F. , Mesa Ruben A. , Palmer Jeanne M. , Michaelis Laura C. , Savona Michael R. 
Published: April 2023

Abstract

Purpose:
Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates with ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of JAK2V617F-mutant cell lines.

Patients and Methods:
In a phase I dose-escalation and -expansion study, we evaluated the safety and efficacy of a selective PI3Kδ inhibitor, umbralisib, in combination with ruxolitinib in patients with MF who had a suboptimal response or lost response to ruxolitinib. Enrolled subjects were required to be on a stable dose of ruxolitinib for ≥8 weeks and continue that MTD at study enrollment. The recommended dose of umbralisib in combination with ruxolitinib was determined using a modified 3+3 dose-escalation design. Safety, pharmacokinetics, and efficacy outcomes were evaluated, and spleen size was measured with a novel automated digital atlas.

Results:
Thirty-seven patients with MF (median age, 67 years) with prior exposure to ruxolitinib were enrolled. A total of 2 patients treated with 800 mg umbralisib experienced reversible grade 3 asymptomatic pancreatic enzyme elevation, but no dose-limiting toxicities were seen at lower umbralisib doses. Two patients (5%) achieved a durable complete response, and 12 patients (32%) met the International Working Group-Myeloproliferative Neoplasms Research and Treatment response criteria of clinical improvement. With a median follow-up of 50.3 months for censored patients, overall survival was greater than 70% after 3 years of follow-up.

Conclusions:
Adding umbralisib to ruxolitinib in patients was well tolerated and may resensitize patients with MF to ruxolitinib without unacceptable rates of adverse events seen with earlier generation PI3Kδ inhibitors. Randomized trials testing umbralisib in the treatment of MF should be pursued.
New Signal Processing Techniques for Phased-Array Oceanographic Radars: Self-Calibration, Antenna Grouping, and Denoising
Authors: Dumas Dylan , Guérin Charles-Antoine 
Published: April 2023

Abstract
Original techniques are proposed for the improvement of surface current mapping with phased-array oceanographic high-frequency radars. The first idea, which works only in bistatic configuration, is to take advantage of a remote transmitter to perform an automatic correction of the receiving antennas based on the signal received in the direct path, an adjustment that is designated as “self-calibration.” The second idea, which applies to both mono- and bistatic systems, consists in applying a direction finding (DF) technique (instead of traditional beamforming), not only to the full antenna array but also to subarrays made of a smaller number of sequential antennas, a method that is referred to as “antenna grouping.” In doing this, the number of sources can also be varied, leading to an increased number of DF maps that can be averaged, an operation that is designated as “source stacking.” The combination of self-calibration, antenna grouping, and source stacking makes it possible to obtain high-resolution maps with increased coverage and is found robust to damaged antennas. The third improvement concerns the mitigation of noise in the antenna signal. These methods are illustrated with the multistatic high-frequency radar network in Toulon and their performances are assessed with drifters. The improved DF technique is found to significantly increase the accuracy of radar-based surface current when compared to the conventional beamforming technique.
Three-Dimensional Fujiwhara Effect for Binary Tropical Cyclones in the Western North Pacific
Authors: Ito Kosuke , Hirano Soichiro , Lee Jae-Deok , Chan Johnny C. L. 
Published: April 2023

Abstract
Recent idealized simulations have shown that a system of binary tropical cyclones (TCs) induces vertical wind shear (VWS) in each TC, which can subsequently modify the tracks of these TCs through asymmetric diabatic heating. This study investigates these three-dimensional effects in the western North Pacific using the best track and ERA5 reanalysis data. The TC motion was found to deviate systematically from the steering flow. The direction of deviation is clockwise and repelling with respect to the midpoint of the binary TCs with a separation distance of more than 1000 km. The large-scale upper-level anticyclonic and lower-level cyclonic circulations serve as the VWS for each TC in a manner consistent with the idealized simulations. The VWS of a TC tends to be directed to the rear-left quadrant from the direction of the counterpart TC, where the maxima of rainfall and diabatic heating are observed. The potential vorticity budget analysis shows that the actual TC motion is modulated by the diabatic heating asymmetry that offsets the counterclockwise and approaching motion owing to horizontal advection when the separation distance of the binary TCs is 1000–2000 km. With a small separation distance (<1000 km), horizontal advection becomes significant, but the impact of diabatic heating asymmetry is not negligible. The abovementioned features are robust, while there are some dependencies on the TC intensities, size, circulation, duration, and geographical location. This research sheds light on the motion of binary TCs that has not been previously explained by a two-dimensional barotropic framework.
Prevalence and correlates of addictive eating behaviours in a large cohort of Australian adolescents
Authors: Smout Scarlett , Gardner Lauren A , Champion Katrina E , Osman Bridie , Kihas Ivana , Thornton Louise , Teesson Maree , Newton Nicola C , Burrows Tracy 
Published: April 2023

Objective: Research shows highly palatable foods can elicit addictive eating behaviours or ‘food addiction’. Early adolescence is theorised to be a vulnerable period for the onset of addictive eating behaviours, yet minimal research has examined this. This study explored the prevalence and correlates of addictive eating behaviours in a large early adolescent sample. Methods: 6640 Australian adolescents (Mage = 12.7 ± 0.5, 49%F) completed an online survey. Addictive eating was measured with the Child Yale Food Addiction Scale (YFAS-C). Negative-binomial generalised linear models examined associations between addictive eating symptoms and high psychological distress, energy drink consumption, sugar-sweetened beverage (SSB) consumption, alcohol use, and cigarette use. Results: Mean YFAS-C symptom criteria count was 1.36 ± 1.47 (of 7). 18.3% of participants met 3+ symptoms, 7.5% endorsed impairment and 5.3% met the diagnostic threshold for food addiction. All examined behavioural and mental health variables were significantly associated with addictive eating symptoms. Effects were largest for high psychological distress and cigarette use; with those exhibiting high psychological distress meeting 0.65 more criteria (95%CI = 0.58–0.72, p < 0.001) and those who smoked a cigarette meeting 0.51 more criteria (95%CI = 0.26–0.76, p < 0.001). High psychological distress and consumption of SSB and energy drinks remained significant when modelling all predictors together. Conclusion: In this large adolescent study, addictive eating symptoms were common. Further research should establish directionality and causal mechanisms behind the association between mental ill-health, alcohol and tobacco use, and addictive eating behaviours. Cross-disciplinary prevention initiatives that address shared underlying risk factors for addictive eating and mental ill-health may offer efficient yet substantial public health benefits.
Health-related quality of life in children, adolescents and young adults with self-harm or suicidality: A systematic review
Authors: Le Ngoc , Belay Yared Belete , Le Long Khanh-Dao , Pirkis Jane , Mihalopoulos Cathrine 
Published: April 2023

Objective: Self-harm and suicidality are associated with substantial social and economic burden, especially among children, adolescents and young adults. The aim of this review was to systematically synthesize the literature on the association between health-related quality of life and self-harm/suicidality in children, adolescents and young adults. Methods: Searches were conducted via MEDLINE, PsycINFO, CINAHL, EconLit and EMBASE. Search terms were the combination of the following blocks: (1) self-harm/suicidality, (2) health-related quality of life/well-being/life satisfaction and (3) children/adolescents/young adults. The quality of studies was assessed using the Effective Public Health Practice Project tool. Results: We identified 23 relevant studies. Findings showed that participants who reported self-harm had lower well-being, life satisfaction or overall health-related quality of life compared to those without self-harm. There was also evidence supporting the association between health-related quality of life and suicidal attempt. However, the results for the association with suicidal ideation remained inconsistent. Additionally, mental health, emotional well-being, physical health, oral health, existential well-being and family quality of life were found to be significant domains associated with self-harm or suicidality. Regarding the quality of included studies, 35% ( n = 8), 39% ( n = 9) and 26% ( n = 6) of studies were scored as ‘Strong’, ‘Moderate’ and ‘Weak’, respectively. Conclusion: Findings from the review showed that health-related quality of life varied according to the severity of suicidality (from ideation to attempt). There was also no evidence to infer the direction of causality between health-related quality of life and self-harm/suicidality. The findings suggest a need for further research, in particular longitudinal studies to fill identified gaps in the literature.
Experiences of care-seeking by schizophrenia patients with delayed diagnosis and treatment in rural China: A qualitative study
Authors: Wang Xiao-qing , Wang Yu , Yu Kai , Ma Rui , Zhang Jia-yuan , Zhou Yu-qiu 
Published: April 2023

Background: Patients with schizophrenia in rural areas of China face severe delays in getting appropriate treatment due to poverty, transportation, and limited availability of mental healthcare services. However, the experiences of care-seeking among patients with delayed diagnosis and treatment in rural areas remain poorly understood, and it remains unclear how these experiences influence patients’ medical mistrust or expectations of care. This study aims to fill that void. Methods: We applied a qualitative phenomenological method. Patients were recruited through purposive sampling at a psychiatric hospital in Harbin, China. Semi-structured, one-to-one interviews were conducted, guided by an interview outline. Thematic analysis was performed using Colaizzi’s seven-step method. Results: Data saturation was achieved after interviewing 13 participants aged 21 to 53 years. Three themes with eight subthemes were identified: (i) Barriers to seeking care, (ii) Feelings for psychiatric treatment, and (iii) Demand for mental healthcare. Several factors that may impede the timely diagnosis and treatment were identified, including patients, physicians, and institutions. The participants described their feelings of adverse treatment experiences, as well as expectations arising from this process. It predominantly covers awareness of the disease, supportive access to care, and geographic accessibility of services. Conclusion: Patients with delayed diagnosis and treatment in rural areas often have negative experiences and various needs for mental health services in the pursuit of effective treatments. Policymakers and health planners should seriously consider the current challenges in rural mental healthcare to develop comprehensive strategies for improving prehospital delays and medical experience for this group of patients.
Bladder exstrophy-epispadias complex related litigation: A legal database review
Authors: Morrill Christian C , Haffar Ahmad , Ditton Thomas , DiCarlo Heather N , Gearhart John P , Crigger Chad 
Published: April 2023

Objective To review the nature and extent of bladder exstrophy-epispadias related malpractice litigation in the United States. Methods Two legal databases (Nexis Uni, WestLaw) were reviewed for state and federal cases using the terms “bladder exstrophy”, “cloacal exstrophy”, “epispadias”, in combination with “medical malpractice”, or “negligence”, or “medical error”, or “complication”, or “malpractice”, or “tort”. Databases were queried from 1948 to 2022 and reviewed for medical and legal details. Results Our search yielded 16 unique legal cases with 6 fitting established criteria for analysis. Urology and paediatric urologists were named in 50% of cases as were community medical systems. Cause for lawsuit included negligence in surgical performance (50%), primary closure of exstrophy (33%), and post-operative care (50%). Settlement agreement was reached in one case (17%). Outcomes favoured the physician in 60% of trials. Lawsuits alleging negligent surgical performance and/or post-operative care exclusively named urologists with outcomes favouring the surgeon in 66% of cases. The settlement payment (n = 1) was $500,000 and monetary damages (n = 1) equated to $1.3 million. Conclusions Malpractice litigation related to BEEC treatment is rare. Trial outcomes favour the medical provider. Cases that resulted in financial liability successfully alleged avoidable negligence resulting in irreversible physical damage. The authors recommend families with BEEC seek board-certified paediatric urologists experienced in treating this complex and/or Bladder Exstrophy Centers of Excellence. Further, we recommend surgeons treating BEEC properly educate patients and families on the severity of this major birth defect including its lifelong implications and need for surgical revisions.
Accuracy of Predicted Intraset Repetitions in Reserve (RIR) in Single- and Multi-Joint Resistance Exercises Among Trained and Untrained Men and Women
Authors: Remmert Jacob F. , Laurson Kelly R. , Zourdos Michael C. 
Published: April 2023

We assessed the accuracy of intraset repetitions in reserve (RIR) predictions on single-joint machine-based movements of trained and untrained men and women. Participants were 27 men ( M age = 22, SE = 0.6 years; M weight = 90.8, SE = 4.0 kg; M height = 182.3, SE = 1.4 cm; M training experience = 66, SE = 9 months) and 31 women ( M age = 20, SE = 0.4 years; M weight = 67.8, SE = 2.3 kg; M height = 167.6, SE = 1.1 cm; M training experience = 22, SE = 4 months). In one session, participants performed a five-repetition maximum (5RM) test on biceps curl, triceps pushdown, and seated row exercises; we then estimated one repetition maximum (1RM). Participants then performed four sets of each exercise, in a randomized order, to the point of momentary muscular failure at 72.5% of 1RM. During each set, participants indicated when they first perceived 5RIR and then predicted RIR on every repetition thereafter until failure. The difference between actual repetitions performed and predicted repetitions at each intraset prediction was determined to be the RIR difference (RIRDIFF). A 3-way repeated measures ANCOVA found that a 3-way interaction was not statistically significant ( p = 0.435) and no covariates of sex ( p = 0.917), training experience ( p = 0.462) nor experience rating RIR significantly affected RIRDIFF ( p = 0.462–0.917). There were significant main effects for the proximity to failure of the prediction and the set number ( p < 0.01) but not for exercise ( p = 0.688). Thus, intraset RIR predictions were more accurate when closer to failure and in later sets, but sex, training experience, and experience rating RIR did not significantly influence RIR prediction accuracy on machine-based single-joint exercises.