bluuebunny/crossref_metadata_2025_split huggingface dataset:
Іnfluence of finishing on the material performances
Authors: Danylkovych Anatolyi , Sanginova Olga 
Published: July 2023

The complex of polyacrylic and polyurethane films physical and mechanical properties and the operational properties of leather decorated with them has been studied. The polyacrylate and polyurethane protective coatings formation is performed on the grain face of the semi-finished leather.
150–200 µm thick films are formed from the polymer solutions and aqueous dispersions. Acrylic films are obtained from a dispersion of methylbutylacrylate and a dispersion modified by acrylic lcarboxyethanolamine of kerosene-gas-oil fraction natural naphthenic acids. Polyurethane films are formed by the method of condensation structure formation in the presence of water vapor based on 4,4’-diphenylmethanediisocyanate, polyethylene glycol and polyester. Polyacrylurethane films are obtained from an aqueous dispersion of polyurethane and acrylate Lepton SPC.
The coating is applied to the semi-finished leather by watering and spraying the polymer composition. The complex of physical-mechanical and sorption-diffusion properties of polymer films has been studied. It was found that the films obtained from the polyacrylurethane composition outperform polyurethane and polyacrylic by 1.9 and 6.7 times, respectively. Modification of the polyurethane composition with a polyacrylic polymer makes it possible to obtain films with higher sorption-diffusion properties.
Polyurethane coated leather is superior to polyacrylic in the complex of physical and mechanical parameters, in particular in terms of adhesive strength in 3.4-4.4 times, and polyacrylurethane coated leather - in 5 times. Such leather has the highest sorbino-diffusion capacity, which is 1.4 times higher in vapor permeability compared to skins with polyacrylic coating. The acrylurethane polymer-based composition is promising formation of eco-coatings based on them in the technology of manufacturing leather materials. The studied polymeric film formers can be used for the formation of various kind protective coatings on a wide range of semi-finished leather products.
IMPLEMENTASI CORPORATE SOCIAL RESPONSIBILITY (CSR) DI ERAMART SAMARINDA DALAM PERSPEKTIF EKONOMI ISLAM
Authors: Syahrullah Syahrullah , Iswadi Muhammad , Tikawati Tikawati , Hasbi Muhamad 
Published: July 2023

Corporate Social Responsibility (CSR) merupakan sebuah gagasan yang menjadikan perusahaan tidak hanya bertanggung jawab pada nilai perusahaan saja, tetapi juga berpijak pada kegiatan ekonomi, sosial dan lingkungan dari sebuah entitas. CSR di perlukan sebagai suatu komitmen berkelajutan dari perusahaan untuk bertanggung jawab secara ekonomi sosial, dan ekologis kepada masyarakat, lingkungan, serta para pemanggku kepentingan (Stageholder). Sehingga dalam pelaksanaan kegiatan Corporate Social Responsibility oleh Eramart Samarinda terdapat beberapa jenis yang di lakukan oleh perusahaan dalam mengimplementasikan kegitan CSR Maka peneliti ingin melakukan penelitian di suatu perusahaan ritel lokal di Samarinda dengan tujuan untuk mengetahui bagaimana implementasi program kerja Corporate Social Responsibility (CSR) yang ada di Eramart Samarinda serta apakah implementsinya sesuai dengan prinsip Ekonomi Islam. Adapun metode yang di gunakan dalam penelitian ini adalah Tield Research (Lapangan) dengan jenis Kualitatif – deskriptif menggunakan analisis isi (Content Analisis) data yang dianalisis yaitu data yang terbagi menjadi dua yakni data primer berupa data langsung dari PT Eramart group dan data sekunder berupa refrensi teori serta dalam teknik pengumpulan data menggunakan Dokumentasi, Observasi, dan Wawancara.Hasil penelitian ini menunjukkan bahwa Implementasi Program Corporate Social Responsibility di Eramart Samarinda dalam bidang pendidikan dan sosial diantaranya 1) dengan menggunakan pola implementasi melalui yayasan atau organisasi perusahaan dengan mendirikan Yayasan Rumah Tahfidz. 2) Implementasi keterlibatan langsung dengan memberikan bantuan kepada yayasan panti asuhan Darul Falah berupa dana dan sembako. 3) Implementasi kerjasama dengan lembaga sosial atau organisasi non Pemerintah. Implementasi Program Kerja Corporate Social Responsibility (CSR) di Eramart Samarinda menggunakan prinsip ekonomi Islam di antaranya Prinsip keadilan, Prinsip Raḥmatan Lil‟alamῑn dan Prinsip Maslahah (Kepentingan Masyarakat).
Effects of Calcium Supplementation on Changes in the Il2, Il4, Il6, Il10 Axes and Oxidative Stress in Pregnant Women at Risk for Pre-eclampsia: Clinical Trial
Authors: Pitilin Erica Brito , Marafon Filomena , Bonadiman Beatriz da Silva Rosa , Pelazza Bruno Bordin , Pillat Micheli Mainardi , Lara Jéssica Dotto , Oliveira Patrícia Pereira , Bagatini Margarete Dulce , Schirmer Janine 
Published: July 2023

Abstract

Background
Pregnant women with hypertensive disorders are at increased risk for inflammatory diseases and oxidative stress. The dilemma raised by the best dosage of calcium supplementation on these factors is evident. The aim of the current study was to examine the effects of calcium on biomarkers of the purinergic system, inflammation and oxidative stress, which are factors contributing to vascular damage in pregnant women at high risk of pre-eclampsia.
Methods
A prospective, double-blind and placebo-controlled study conducted with 101 women at risk of pre-eclampsia were randomized to take 500 mg calcium/day or 1,500 mg calcium/day or placebo for 6 weeks from the 20th gestational week until delivery. Fasting blood samples were collected at the beginning of the study and 6 weeks after the intervention.
Results
Taking calcium supplements (500 mg calcium/day) led to a significant increase in ATP hydrolysis (p < 0.05), NTPDase activity with increased hydrolysis of ADP and AMP nucleotides in platelets and lymphocytes. In the intragroup analysis IL-2, IL-6, IL-4 and interferon-ɣ presented lower values in the calcium 1,500 mg/day group (p < 0.005). Oxidative stress was assessed by TBARS pro-oxidant marker, with an increase for the calcium groups when compared to the placebo group. The Vitamin C antioxidant marker presented a significant increase (p < 0.005) for the group that received high calcium doses.
Conclusions
Calcium administration for 6 weeks had antioxidant action and positively modulated the purinergic system and inflammatory markers in pregnant women at risk of pre-eclampsia.
Two-step hot isostatic pressing densification achieved non-porous fully-densified wood with enhanced physical and mechanical properties
Authors: Correa Esteban , Maturana Juan , Guindos Pablo , Lagos Jorge , Arroyave Catalina , Echeverría Félix 
Published: July 2023

Abstract
A new two-step densification method for wooden materials is proposed. This method achieved wood that was virtually non-porous and fully densified exceeding any value ever reported for a hardwood species. In the first step, the compressive strength of the anatomical wood structure is reduced by delignification, and, in the second, a full densification is achieved by hot isostatic pressing under argon atmosphere. Three tropical hardwood species with distinct anatomical characteristics and properties were used to test the method. The HIP-densified wood's microstructural, chemical, physical, and mechanical properties were assessed. The results indicate that proposed method was effective for all the tested species, obtaining a material that it is mostly non porous, shows homogenous density patterns, preserves the original volume, features great stability and it has enhanced mechanical properties. Therefore, the HIP wood densification may be a promising densification technique since it overcomes several limitations faced by previous wood densification methods.
Non-Markovian cost function for quantum error mitigation with Dirac Gamma matrices representation
Authors: Ahn Doyeol 
Published: July 2023

Abstract
This paper investigates the non-Markovian cost function in quantum error mitigation (QEM) and employs Dirac Gamma matrices to illustrate two-qubit operators, significant in relativistic quantum mechanics. Amid the focus on error reduction in noisy intermediate-scale quantum (NISQ) devices, understanding non-Markovian noise, commonly found in solid-state quantum computers, is crucial. We propose a non-Markovian model for quantum state evolution and a corresponding QEM cost function, using simple harmonic oscillators as a proxy for environmental noise. Owing to their shared algebraic structure with two-qubit gate operators, Gamma matrices allow for enhanced analysis and manipulation of these operators. We evaluate the fluctuations of the output quantum state across various input states for identity and SWAP gate operations, and by comparing our findings with ion-trap and superconducting quantum computing systems' experimental data, we derive essential QEM cost function parameters. Our findings indicate a direct relationship between the quantum system's coupling strength with its environment and the QEM cost function. The research highlights non-Markovian models' importance in understanding quantum state evolution and assessing experimental outcomes from NISQ devices.
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity
Authors: Chen Jiasheng , Lin Yuxin , Zheng Shukai , Chen Qingshan , Tang Shijie , Zhong Xiaoping 
Published: July 2023

Abstract
Background: A chromobox homologue 3(CBX3) is elevated in various cancers and significantly contributes to the promotion of malignant behavior; despite this, its exact involvement in clear cell renal cell carcinoma (ccRCC) is yet unknown.
Methods: The Cancer Genome Atlas database served to evaluate CBX3 production and its connection to survival in patients with ccRCC. Our team evaluated the effects of knockdown of CBX3 levels in ccRCC cell populations using in vitro together with in vivo models. CBX3, proteins related to death, and EMT-related proteins were measured in ccRCC cells using western blotting and immunohistochemical assays. Through the analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) and GeneOntology (GO) and Gene Set Enrichment Analysis (GSEA), the biological processes and signal pathways related to CBX3 expression were identified. Immune-related activity reduced by CBX3 was assessed using various online tools.
Results: Both genomic and protein expression showed that CBX3 was upregulated in ccRCC. Further functional analyses revealed that CBX3 played a crucial role in enhancing cell growth, migration, and epithelial-to-mesenchymal transition (EMT) in vitro along with in vivo. Moreover, we provide distinct mechanistic evidence that CBX3 achieves all its pathological functions in ccRCC by activating the PI3K/AKT pathway. Finally, immunoassays revealed that CBX3, a possible biomarker of ccRCC, was significantly associated with immunity.
Conclusions: Our results suggest that CBX3 is overexpressed and promotes ccRCC advancement through PI3K/AKT activation and even immunological dysregulation, making it a potentially viable and beneficial target.
Structural and intermediary socioeconomic determinants of health associated with hospitalizations and doctor visits in older adults in Europe.
Authors: Amo-Saus Elisa , Martínez-Lacoba Roberto , Pardo-García Isabel , Moya-Martínez Pablo 
Published: July 2023

Abstract
The aging population in Europe has increased the demand for healthcare, with doctor visits and hospitalizations being key indicators of this trend. This demand is influenced by various individual and lifestyle factors, as well as structural and systemic macrovariables that cannot be modified through behavioral changes. This study aimed to investigate inequalities in access to healthcare across European countries, finding that macrovariables explained between 3.3% and 4.9% of the differences in the likelihood of hospitalizations and approximately 10% of the likelihood of visiting a doctor at least once a year. Life expectancy and number of beds were the macrovariables most associated with a reduced probability of hospitalization and doctor visits, respectively. The study also found that comorbidity and employment status were risk factors associated with hospitalization and doctor visits, while physical activity was a protective factor. These findings are useful in developing healthcare policies at the European level.
Identification of common hub genes in gastrointestinal cancers and their role in prognosis and Immune cell infiltration in hepatocellular carcinoma
Authors: Yang Cheng-Lei , Chen Bing-Sheng , Li Shuai-Jun , Hu Jun-Wen , Li Yuan-Kuan , Wu Zong-Ze , Zhou Min , Song Rui , Yu Hong-Ping , Xiang Bang-De 
Published: July 2023

Abstract
Background
Common hub genes (CHGs) in gastrointestinal cancers (GICs) and their prognostic potential and immune infiltration in hepatocellular carcinoma (HCC) are limited.
Methods
Differential analysis of genes in the six GICs was performed, and CHGs were identified using the survival and protein-protein interaction (PPI) network analyses. A polygenic prognostic model was constructed based on the CHGs using the LASSO-Cox regression algorithm and validated in two cohorts. CHGs-related multivariate Cox regression and immune infiltration analyses were performed.
Results
Ten CHGs (TOP2A, CCNB1, CDK1, MAD2L1, RRM2, CCNA2, BUB1B, CDC6, AURKA, and BUB1) were obtained. In The Cancer Genome Atlas (TCGA) cohort, a 3-gene (CCNB1, MAD2L1, and BUB1) prognostic model was built. A significant difference was showed in the overall survival of patients between the two groups. Moreover, both type I and II interferon response pathways decreased in high-risk HCC patients. These results were also validated in the ICGC and internal cohorts.
Conclusions
10 CHGs in six GICs was revealed. In HCC, a prognostic model based on the 3 CHGs in GICs was constructed. Both type I and II interferon response pathways markedly decreased in the high-risk group of HCC patients. This might provide novel perspectives for the targeting and immunotherapy of GICs.
Expression of CYP4X1 in colorectal carcinoma is associated with metastasis and poor prognosis
Authors: Kim Sooyoun , Hong Inpyo , Lee Minho , Kim Hak Chun , Ji Sanghee , Kim Hyeongjoo , Kwak Hyoung Jong , Kim Chang-Jin , Jeong Dongjun 
Published: July 2023

Abstract
Background
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate. The recurrence rate of colorectal cancer is 30–50%, and the survival rate of patients with recurrence and metastasis is very low. Prognostic biomarkers of colorectal cancer can be guidelines for the therapeutic management of the cancer patients. The cytochrome P450 (CYP) family is upregulated in various cancers and contributes to cancer cell proliferation, signaling and drug metabolism. In addition, the Cytochrome P450 family is related to various xenobiotics and endogenous compounds. Nevertheless, the role of CYP4X1 in regulating the progression and growth of colorectal cancer remains unclear.
Methods
To investigate the relationship between CYP4X1 expression and colorectal cancer, CYP4X1 expression was inhibited in colorectal cancer cells using siRNA and confirmed at mRNA and protein levels. WST-1, Transwell and colony formation assays were performed using CYP4X1 downregulated cells. We performed immunohistochemistry for the CYP4X1 expression of 243 colorectal cancer tissues and investigated the expression with the patient’s clinical parameters.
Results
In colorectal cancer, downregulated CYP4X1 suppressed proliferation, migration, invasion, and colony formation. CYP4X1 overexpression was found to be related to TNM stage, degree of tumor differentiation, invasion of the primary tumor, clinical stages, and lymph node metastasis. In addition, the high CYP4X1 expression revealed a shorter survival period than those with low CYP4X1 expression by Kaplan-Meier survival analysis.
Conclusions
Upregulated CYP4X1 may be an independent prognostic marker for CRC, and CYP4X1 may be a therapeutic target for CRC patients. Epoxyeicosatrienoic acid (EET) derived from arachidonic acid has been implicated in carcinogenesis due to its CYP polymorphism. Whether CYP4X1 regulates EET in CRC remains unknown. Therefore, the increased CYP4X1 in EET requires further studies on the correlation between EGFR phosphorylation and PI3K/AKT and MAPK signaling.
Antibacterial and swelling performance of superabsorbent polymers incorporated with magnesium oxide nanoparticles
Authors: Noor Hafiz Muhammad Zia ul , Ahmad Ali , Rafique Sikander , Akram Naeem , Durrani Abdullah Khan 
Published: July 2023

Abstract
Super absorbent copolymer incorporated with magnesium oxide nanoparticles was investigated for absorptivity in an aqueous solution and anti-bacterial activity against gram-negative Escherichia Coli. Cross-linked copolymers of ionic acrylic acid (A.A.) and nonionic acrylamide (AAm) were synthesized in an aqueous solution via free radical polymerization by providing vigorous mixing and heating. MgO nanoparticles were incorporated into the super-absorbent copolymers during polymerization. For all preparations, the degree of neutralization of acrylic acid was fixed at 75%, the amount of cross-linker NN-MBA was 1% moles of initial monomer, and the initiator potassium persulfate amount was 150 mg. The highest absorption of distilled water was 147 g/g at 80% acrylic acid without MgO nanoparticles content (AA30M). While in 0.9% saline solution, the highest absorption capacity was 39 g/g at 40% acrylamide content (AA10M). Reduced swelling ability was observed by increased magnesium oxide nanoparticles dosage as 121.5 g/g in AA33M copolymer. However, maximum bactericidal activity was observed for AA33M on the agar plate method and Lysogeny broth medium method via UV-spectrophotometer, where the optical density (O.D.) 600 was 0.022. This study is expected to provide a viable solution due to its eco-friendliness, ease of availability, and low cost.
Prioritizing Educational Initiatives on Emerging Technologies for Italian Pediatricians: bibliometric review and a survey
Authors: Tozzi Alberto Eugenio , Gesualdo Francesco , Pandolfi Elisabetta , Ferro Diana , Cinelli Giulia , Bozzola Elena , Aversa Tommaso , Mauro Antonio Di , Mameli Chiara , Croci Ileana 
Published: July 2023

Abstract
Background
Emerging technologies have demonstrated outstanding potential in improving healthcare, yet their full integration remains a challenge for all medical specialties, including pediatrics. To support the swift implementation of technologies, we identified the current trends through a bibliometric review, and we conducted a survey on Italian pediatricians to gauge educational needs and willingness to integrate technologies into clinical practice.
Methods
A working group of pediatricians representing various backgrounds designed and coordinated the study. To identify relevant topics for educational strategy development, we focused on virtual reality, telehealth, natural language processing, smartphone applications, robotics, genomics, and artificial intelligence. A bibliometric analysis limited to 2018-2023 was performed to identify trends and emerging applications within each topic. Based on the results, a questionnaire was developed and made available online to all Italian pediatricians. The results were analyzed through descriptive analysis and a multivariable logistic regression to explore associations between technology adoption and sociodemographic characteristics.
Results
A total of 3,253 publications were found, with Telehealth and Telemedicine having the highest number of publications and Natural Language Processing the lowest. The number of respondents to the online questionnaire was 1,540, predominantly medical doctors with over 20 years of experience working as family pediatricians. Telehealth had the highest level of knowledge (95.2%), followed by smartphone applications (89.1%) and genomics (63.2%). The greatest potential for increased use through education programs was projected for natural language processing (+43.1%), artificial intelligence (+39.6%), and virtual and mixed reality (+38.1%). Female respondents and older individuals were less likely to use emerging technologies. Hospital pediatricians and residents were more likely to use AI.
Conclusions
We developed a replicable strategy to identify emerging themes in medical technologies relevant to pediatrics and assess the educational needs of pediatricians. A significant gap still exists between current and potential usage of emerging technologies among Italian pediatricians although they showed a positive attitude towards implementing these technologies following specific education programs. The study highlights the need for comprehensive education programs on emerging technologies in pediatrics and recommends addressing gender and age disparities in technology adoption.
Causal Relationship between Multiple Autoimmune Diseases and Pregnancy Loss: A Two-Sample Mendelian Randomization Study
Authors: Chen Liang , Guo Juanjuan , Xia Yi , Wang Mei , Zhang Yuanzhen , Yang Meitao 
Published: July 2023

Abstract
Background
Although systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) have been clinically confirmed to cause pregnancy loss and effective clinical treatment and nursing programs have been proposed to greatly improve pregnancy outcomes, the relationship between other types of autoimmune diseases (ADs) and pregnancy loss remains unclear due to inconsistent conclusions from existing observational studies. This has hindered the formation of clinical consensus and the implementation of comprehensive management for pregnant women with ADs. To address this gap, we executed a two-sample mendelian randomization(MR) approach intending to assess the potential causal impact of 29 ADs on 7 types of pregnancy loss.
Results
The two-sample MR investigations with inverse variance weighted(IVW) approach revealed strong causal relationship between broadly defined ADs and stillbirth, spontaneous miscarriage, or termination [Odd ratios (ORs), 1.00846; 95% confidence intervals (CIs), 1.00095–1.01602; p value = 0.027]. Type 1 diabetes (T1D) exhibited a positive link with the number of spontaneous miscarriages [OR, 1.00709; 95%CI, 1.00134–1.01288; p value = 0.016]. Meanwhile, autoimmune hypothyroidism was strongly linked to ever had stillbirth, spontaneous miscarriage, or termination [OR, 1.00413; 95%CI, 1.00043–1.00784; p value = 0.028]. Additionally, crohn's disease (CD), a gastrointestinal immune disease, exhibited a significantly positive correlation with spontaneous abortion [OR, 1.00036; 95%CI, 1.00012–1.00059; p value = 0.003]. Interestingly, we observed that rheumatoid arthritis (RA) indicated a negative connection with spontaneous abortion [OR, 0.99953; 95%CI, 0.99909–0.99997; p value = 0.036].
Conclusion
The findings of this study implied a causal association between different ADs and pregnancy loss, thus advancing our comprehension of the ADs-mediated etiology and pathogenesis of pregnancy loss.