bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional and psychosexual well‐being is influenced by ethnicity and birthplace in women and individuals with polycystic ovary syndrome in the UK and India
Authors: Sheikh Jameela , Khalil Halimah , Shaikh Salomi , Hebbar Meghnaa , Zia Nawal , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Subramanian Anuradhaa , Malhotra Kashish , Chapman Rachel , Gillett Caroline , Gleeson Helena K. , Robinson Lynne , Chu Justin J. , Lathia Tejal , Selvan Chitra , O'Reilly Michael W. , Manolopoulos Konstantinos N. , Arlt Wiebke , Kempegowda Punith ,   the PCOS SEva team
Published: February 2023

AbstractObjectiveTo assess the association of ethnicity and birthplace on emotional and psychosexual well‐being in women with polycystic ovary syndrome (PCOS).DesignCross‐sectional study.SettingCommunity recruitment via social media campaigns.PopulationWomen with PCOS completing an online questionnaire in September–October 2020 (UK) and May–June 2021 (India).MethodsThe survey has five components, with a baseline information and sociodemographic section followed by four validated questionnaires: Hospital Anxiety and Depression Scale (HADS); Body Image Concern Inventory (BICI); Beliefs About Obese Persons Scale (BAOP); and Female Sexual Function Index (FSFI).Main outcome measuresWe used adjusted linear and logistic regression models, adjusting for age, education, marital status and parity, to evaluate the impact of ethnicity and birthplace on questionnaire scores and outcomes (anxiety and/or depression, HADS ≥ 11; body dysmorphic disorder (BDD), BICI ≥ 72).ResultsA total of 1008 women with PCOS were included. Women of non‐white ethnicity (613/1008) reported higher rates of depression (OR 1.96, 95% CI 1.41–2.73) and lower BDD (OR 0.57, 95% CI 0.41–0.79) than white women (395/1008). Women born in India (453/1008) had higher anxiety (OR 1.57, 95% CI 1.00–2.46) and depression (OR 2.20, 95% CI 1.52–3.18) but lower BDD rates (OR 0.42, 95% CI 0.29–0.61) than women born in the UK (437/1008). All sexual domains, excluding desire, scored lower for non‐white women and women born in India.ConclusionsNon‐white women and women born in India reported higher emotional and sexual dysfunction, whereas white women and women born in the UK reported higher body image concerns and weight stigma. Ethnicity and birthplace need to be considered for tailored, multidisciplinary care.
Type 1 diabetes management: Room for improvement
Authors: Varkevisser Rita D. M. , Birnie Erwin , Mul Dick , van Dijk Peter R. , Aanstoot Henk‐Jan , Wolffenbuttel Bruce H. R. , van der Klauw Melanie M. 
Published: February 2023

AbstractAims/HypothesisOptimal diabetes care and risk factor management are important to delay micro‐ and macrovascular complications in individuals with type 1 diabetes (T1D). Ongoing improvement of management strategies requires the evaluation of target achievement and identification of risk factors in individuals who do (or do not) achieve these targets.MethodsCross‐sectional data were collected from adults with T1D visiting six diabetes centers in the Netherlands in 2018. Targets were defined as glycated hemoglobin (HbA1c) <53 mmol/mol, low‐density lipoprotein‐cholesterol (LDL‐c) <2.6 mmoL/L (no cardiovascular disease [CVD] present) or <1.8 mmoL/L (CVD present), or blood pressure (BP) <140/90 mm Hg. Target achievement was compared for individuals with and without CVD.ResultsData from 1737 individuals were included. Mean HbA1c was 63 mmol/mol (7.9%), LDL‐c was 2.67 mmoL/L, and BP 131/76 mm Hg. In individuals with CVD, 24%, 33%, and 46% achieved HbA1c, LDL‐c, and BP targets respectively. In individuals without CVD these percentages were 29%, 54%, and 77%, respectively. Individuals with CVD did not have any significant risk factors for HbA1c, LDL‐c, and BP target achievement. In comparison, individuals without CVD were more likely to achieve glycemic targets if they were men and insulin pump users. Smoking, microvascular complications, and the prescription of lipid‐lowering and antihypertensive medication were negatively associated with glycemic target achievement. No characteristics were associated with LDL‐c target achievement. Microvascular complications and antihypertensive medication prescription were negatively associated with BP target attainment.ConclusionOpportunities for improvement of diabetes management exist for the achievement of glycemic, lipid, and BP targets but may differ between individuals with and without CVD.
Paradigm guiding to tapering or discontinuation of biologic and targeted synthetic disease‐modifying antirheumatic drugs in the treatment of patients with rheumatoid arthritis: Results from a local prospective study
Authors: Kaban Nedim , Harman Halil 
Published: February 2023

AbstractObjectiveWe prospectively conduct the current study to figure out predicting factors whether biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) can be discontinued or tapered in patients with rheumatoid arthritis (RA).Materials and MethodsThe study population encompassed 126 consecutive RA patients on b/tsDMARDs for at least 1 year. Remission was defined as a Disease Activity Score of 28 joints (DAS28) ‐ erythrocyte sedimentation rate <2.6. The b/tsDMARD dosing interval was increased in patients in remission for at least 6 months. In patients in whom the b/tsDMARD dosing interval could be increased by 100% for at least 6 months, the b/tsDMARD was stopped at the end of this period. Disease relapse was defined as deterioration from remission to moderate or high disease activity.ResultsThe mean duration of b/tsDMARD treatment for all patients was 2.54 ± 1.55 years. Logistic regression analysis did not identify any independent predictor of treatment discontinuation. Independent predictors for tapering in b/tsDMARD treatment are no switch to another therapy and lower baseline DAS28 scores (respectively, P = .029, .024). Time to relapse after tapering was shorter in patients requiring corticosteroids when the 2 groups were compared with the log‐rank test (2.83 vs 10.8 months; P = .05).ConclusionIt seems a reasonable approach to consider b/tsDMARD tapering in patients with remission period of >3.5 months, lower baseline DAS28 scores and without requiring corticosteroid use. Unfortunately, no predictor has been found to predict b/tsDMARD discontinuation.
Inhibitory control in young adult women with fetal alcohol syndrome: Findings from a pilot functional magnetic resonance imaging study
Authors: Rau Johanna M. H. , Sundermann Benedikt , Pfleiderer Bettina , Dehghan‐Nayyeri Mahboobeh , Garde Stefan , Weglage Josef , Feldmann Reinhold 
Published: February 2023

AbstractBackgroundExecutive dysfunction, especially impaired inhibitory control, is a common finding in individuals with fetal alcohol syndrome (FAS). Previous research has mostly focused on neural correlates of inhibitory deficits in children and adolescents. We investigated inhibitory functions and underlying cerebral activation patterns in young adult women with FAS.MethodsTask performance and functional magnetic resonance imaging (fMRI) data were acquired during a Go/NoGo (GNG) inhibition task in 19 young adult women with FAS and 19 healthy female control subjects. Whole‐brain activation and task performance analyses were supplemented by region of interest (ROI) analyses of fMRI data within a predefined cognitive control network (CCN).ResultsTask performance did not differ significantly between groups on errors of commission, associated with inhibitory control. Similarly, overall activation within the preselected ROIs did not differ significantly between groups for the main inhibitory contrast NoGo > Go. However, whole‐brain analyses revealed activation differences in the FAS group when compared to controls under inhibitory conditions. This included hyperactivations in the left inferior frontal, superior temporal, and supramarginal gyri in the FAS group. Likewise, lateralization tendencies toward right‐hemispheric ROIs were weaker in FAS subjects. In contrast to comparable inhibitory performance, attention‐related errors of omission were significantly higher in the FAS group. Correspondingly, FAS subjects had lower activity in attention‐related temporal and parietal areas.ConclusionsThe known alterations of inhibitory functions associated with prenatal alcohol exposure in children and adolescents were not seen in this adult sample. However, differential brain activity was observed, reflecting potential compensatory mechanisms. Secondary results suggest that there is impaired attentional control in young adult women with FAS.
Transient apical breakdown of a discoloured maxillary central incisor during orthodontic treatment: A case report
Authors: Zhu Zufeng 
Published: February 2023

AbstractTransient apical breakdown (TAB) appears to be a repair process taking place in the pulp and periapical area of traumatised teeth which may display crown discoloration and have no responses to pulp sensitivity tests. Few TAB cases induced by orthodontic forces have been reported so far. Presented is a case report in which TAB occurred on the maxillary right central incisor during orthodontic treatment. The affected tooth suddenly displayed crown discoloration and had no response to pulp testing at 6 weeks after the placement Invisalign Clear Aligner appliances. Condition of the discoloured tooth was monitored by periodic recall examinations without any active treatment. Six months after the occurrence of discoloration, the affected tooth recovered to its original shade and responded normally to pulp sensitivity tests.
Bag‐in‐the‐lens intraocular lens implantation before 12 weeks of age in congenital cataract
Authors: Sand Mari Kathrine , Cholidis Symira , Kristianslund Olav , Drolsum Liv 
Published: February 2023

AbstractPurposeThe aim of this study was to evaluate the intra‐ and postoperative complications, especially the risk of visual axis opacification (VAO), following the implantation of the bag‐in‐the‐lens (BIL) intraocular lens (IOL) in infants with congenital cataract operated on before 12 weeks of age.MethodsInfants operated on before 12 weeks of age between June 2020 and June 2021 with a follow‐up longer than 1 year were included in the present retrospective study. This was a first‐experience cohort of an experienced paediatric cataract surgeon with this type of lens.ResultsNine infants (13 eyes) with a median age at surgery of 28 days (range, 21–49 days) were included. The median follow‐up time was 21.6 months (range, 12.2–23.4 months). The lens was correctly implanted with the anterior and posterior capsulorhexis edges placed into the interhaptic groove of the BIL IOL in seven of 13 eyes; none of these eyes developed VAO. In the remaining six eyes, the IOL was only fixated to the anterior capsulorhexis edge, and in these cases, an anatomical anomaly of the posterior capsule and/or anterior vitreolenticular interface dysgenesis were observed. These six eyes developed VAO. One eye had a partial iris capture in the early postoperative phase. Otherwise, the IOL remained well centred and stable in all eyes. Anterior vitrectomy was necessary in seven eyes due to vitreous prolapse. One patient with unilateral cataract was diagnosed with bilateral primary congenital glaucoma at 4 months of age.ConclusionImplantation of the BIL IOL is safe even in the youngest age group less than 12 weeks of age. Although being a first‐experience cohort, the BIL technique is shown to reduce the risk of VAO and the number of surgical procedures.
Patient‐targeted interventions for opioid deprescribing: An overview of systematic reviews
Authors: Langford Aili V. , Schneider Carl R. , Lin Chung‐Wei Christine , Bero Lisa , Collins Jack C. , Suckling Benita , Gnjidic Danijela 
Published: February 2023

AbstractBackgroundDeprescribing (reduction or cessation) of prescribed opioids can be challenging for both patients and healthcare professionals.ObjectiveTo synthesize and evaluate evidence from systematic reviews examining the effectiveness and outcomes of patient‐targeted opioid deprescribing interventions for all types of pain.MethodsSystematic searches were conducted in five databases with results screened against predetermined inclusion/exclusion criteria. Primary outcomes were (i) reduction in opioid dose, reported as change in oral Morphine Equivalent Daily Dose (oMEDD) and (ii) success of opioid deprescribing, reported as the proportion of the sample for which opioid use declined. Secondary outcomes included pain severity, physical function, quality of life and adverse events. The certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.FindingsTwelve reviews were eligible for inclusion. Interventions were heterogeneous in nature and included pharmacological (n = 4), physical (n = 3), procedural (n = 3), psychological or behavioural (n = 3) and mixed (n = 5) interventions. Multidisciplinary care programmes appeared to be the most effective intervention for opioid deprescribing; however, the certainty of evidence was low, with significant variability in opioid reduction across interventions.ConclusionsEvidence is too uncertain to draw firm conclusions about specific populations who may derive the greatest benefit from opioid deprescribing, warranting further investigation.
Medication incidents and medication errors in Danish healthcare: A descriptive study based on medication incident reports from the Danish Patient Safety Database, 2014–2018
Authors: Tchijevitch Olga , Hallas Jesper , Bogh Søren B. , Birkeland Søren F. 
Published: February 2023

AbstractIn Denmark, reporting of safety incidents to the nationwide Danish Patient Safety Database (DPSD) is mandatory. Medication incident reports constitute the largest category of safety reports. We aimed to provide numbers and characteristics of medication incidents and MEs reported to DPSD focusing on medication, their severity and the trends therein. This is a cross‐sectional study of medication incident reports for individuals ≥18, submitted to DPSD in 2014–2018. We performed analyses on the (1) medication incident and (2) ME levels. Out of 479 814 incident reports, 61.18% (n = 293 536) were related to individuals ≥70 and 44.6% (n = 213 974) to nursing homes. Most of the events were harmless (70.87%, n = 340 047) and 0.8% (n = 3859) had caused severe harm or death. ME‐analysis (n = 444 555) revealed that paracetamol and furosemide were the most frequently reported drugs. The most common drugs for severe and fatal MEs were warfarin, methotrexate, potassium chloride, paracetamol and morphine. When the reporting ratio for all MEs and harmful MEs was considered, other drugs than the most frequently reported ones were found to be associated with harm. We found a large proportion of harmless medication incident reports and reports from community healthcare services and identified high‐risk medicines associated with harm.
Microstructure and asset pricing: An insight on African frontier stock markets
Authors: Hikouatcha Prince , Njamen Kengdo Arsène Aurelien , Bidias Menik Hans Patrick , Tchoffo Tioyem Pierre Ghislain , Nchofoung Tii Njivukuh 
Published: February 2023

AbstractThis article investigates the impact of microstructure factors on asset pricing in some African stock markets. We use data on stocks listed on the Johannesburg Stock Exchange, the “Bourse Régionale des Valeurs Mobilières,” and the Nigeria Stock Exchange, and we consider international portfolio management from 2000 to 2014. Generalized least square and fixed effect are estimation methods used to highlight the effect of microstructure variables on expected return. At the same time, panel smooth transition regression (PSTR) modeling is considered to identify the thresholds in this effect. The results show that liquidity and to a lesser extent the number of trading days are the most common significant microstructure variables for all the studied markets. However, other variables’ effects on the return are specific to the considered stock markets. Furthermore, the PSTR estimator reveals that the impact of indicated factors on asset pricing is not linear because it produces a double threshold between return and microstructure.
Upper thermal limits predict herpetofaunal responses to forest edge and cover
Authors: Veselka Andrew J. , Aponte‐Gutiérrez Andrés , Medina‐Báez Osmary A. , Watling James I. 
Published: February 2023

AbstractAmphibians and reptiles are sensitive to changes in the thermal environment, which varies considerably in human‐modified landscapes. Although it is known that thermal traits of species influence their distribution in modified landscapes, how herpetofauna respond specifically to shifts in ambient temperature along forest edges remains unclear. This may be because most studies focus on local‐scale metrics of edge exposure, which only account for a single edge or habitat patch. We predicted that accounting for the combined effect of multiple habitat edges in a landscape would best explain herpetofaunal response to thermally mediated edge effects. We (1) surveyed herpetofauna at two lowland, fragmented forest sites in central Colombia, (2) measured the critical thermal maximum (CTmax) of the species sampled, (3) measured their edge exposure at both local and landscape scales, and (4) created a thermal profile of the landscape itself. We found that species with low CTmax occurred both further from forest edges and in areas of denser vegetation, but were unaffected by the landscape‐scale configuration of habitat edges. Variation in the thermal landscape was driven primarily by changes in vegetation density. Our results suggest that amphibians and reptiles with low CTmax are limited by both canopy gaps and proximity to edge, making them especially vulnerable to human modification of tropical forest.Abstract in Spanish is available with online material.
Making the most out of the innovation of meaning: The importance of inclusion for creativity in inside‐out envisioning
Authors: Goto Satoru , Makino Hikaru , Ando Takuo 
Published: February 2023

Innovation of meaning (IoM) is one of the streams that has attracted attention in design thinking research. Inside‐out envisioning aims to assist non‐designer employees practice IoM in a similar manner to how visionary executives and designers perform. The process starts with exposing their intrinsic visions to innovate the dominant social or organizational meanings. This makes the employees' creativity that comes from intrinsic goals and values an important driving force of inside‐out envisioning. Thus, it is crucial to foster an organizational culture that encourages employees to engage in inside‐out envisioning and enhance their creativity. This study explores whether inclusion, as an organizational culture, is an antecedent of creativity in inside‐out envisioning. Inclusion refers to a state in which an individual's uniqueness is valued by other group members and externalized to improve group performance. Based on data from a survey conducted with 1104 Japanese employees, this study reveals that inclusion significantly impacts creativity in inside‐out envisioning. A multigroup analysis demonstrates differences in the effects of the mediating variables of this relationship based on the successful experience of inside‐out envisioning. This study concludes that it is important for design thinking researchers to study inclusion more deeply as a way to implement inside‐out envisioning.
Age‐dependent changes in the prognostic advantage of papillary thyroid cancer in women: A SEER‐based study
Authors: Liu Qi , Ma Bing , Song Mingyuan , Sun Wei , Zhang Hao 
Published: February 2023

AbstractBackgroundPapillary thyroid cancer (PTC) is more prevalent in women, and women show a better prognosis than men; however, the factors contributing to this prognostic difference are confounding. Therefore, we aimed to investigate the effect of the interaction between sex and age on the prognosis of PTC.MethodsA total of 108,459 patients with PTC were retrospectively analysed, and Cox‐regression models were used to assess differences in disease specific survival (DSS) by sex, with inverse probability of treatment weighting (IPTW) to control for between‐group differences in prognosis by sex due to age change. Restricted cubic splines were used to analyse prognostic differences between sexes for papillary thyroid microcarcinoma (PTMC) and PTC. Multiple mediation analyses were used to assess the direct or indirect effect of sex on DSS.ResultsThe DSS was higher for women than men (98.6% vs. 95.4%, χ2 = 458.57, p < .001). After IPTW adjustment, the DSS of women was better than that of men (HR = 0.67, 0.60−0.76). In the subgroup analysis, women had an advantage in DSS across most age intervals (crude HR = 0.166 [0.082−0.337], p < .001, IPTW‐adjusted HR = 0.331 [0.161−0.681], p < .001). The difference between the two gradually narrowed with increasing age, and the prognosis of women was better than that of men in PTMC, while this advantage was not obvious in PTC.ConclusionsThe overall PTC prognosis of women is better than that of men, but the prognostic advantage of women diminishes with age and tumour growth. These differences in prognosis may be due to some indirect factors caused by different sexes.
Epoxy allergy, investigation of a modern industry
Authors: Lejding Tina , Källberg Kajsa , Bergendorff Ola , Jacobsson Susanne , Svedman Cecilia , Bruze Magnus 
Published: February 2023

AbstractBackgroundFive workers from an industry manufacturing various articles from carbon fibre reinforced epoxy plastics were referred to our department because of suspected occupational allergic contact dermatitis (OACD). When patch tested, four of them had positive reactions to components of epoxy resin systems (ERSs) that could explain their current skin problems. All of them had been working at the same workstation at a specially designed pressing machine, with operations including manually mixing epoxy resin with hardener. Multiple cases of OACD in the plant prompted an investigation including all workers with possible risk exposures at the plant.ObjectivesTo investigate the prevalence of occupational dermatoses and contact allergies among the workers at the plant.Materials and MethodsTotally 25 workers underwent investigation that included a brief consultation with a standardized anamnesis and clinical examination followed by patch testing.ResultsERSs‐related reactions were found in 7 of the 25 investigated workers. None of the seven had a history of previous exposure to ERSs and they are regarded as sensitized through work.ConclusionsTwenty‐eight percent of investigated workers showed reactions to ERSs. Of these the majority would have been missed if supplementary testing would not have been added to testing with the Swedish base line series.