bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic artery thrombosis and use of anticoagulants and antiplatelet agents in pediatric liver transplantation
Authors: Feldman Keith , Heble Daniel E. , Hendrickson Richard J. , Fischer Ryan T. 
Published: August 2023

AbstractBackgroundHepatic artery thrombosis (HAT) is a reported complication of 5%–10% of pediatric liver transplantations, rates 3–4 times that seen in adults. Early HAT (seen within 14 days after transplant) can lead to severe allograft damage and possible urgent re‐transplantation. In this report, we present our analysis of HAT in pediatric liver transplant from a national clinical database and examine the association of HAT with anticoagulant or antiplatelet medication administered in the post‐operative period.MethodsData were obtained from the Pediatric Health Information System database maintained by the Children's Hospital Association. For each liver transplant recipient identified in a 10‐year period, diagnosis, demographic, and medication data were collected and analyzed.ResultsOur findings showed an average rate of HAT of 6.3% across 31 centers. Anticoagulant and antiplatelet medication strategies varied distinctly among and even within centers, likely due to the fact there are no consensus guidelines. Notably, in centers with similar medication usage, HAT rates continue to vary. At the patient level, use of aspirin within the first 72 h of transplantation was associated with a decreased risk of HAT, consistent with other reports in the literature.ConclusionWe suggest that concerted efforts to standardize anticoagulation approaches in pediatric liver transplant may be of benefit in the prevention of HAT. A prospective multi‐institutional study of regimen—possibly including aspirin—following transplantation could have significant value.
Safety and efficacy of bronchial thermoplasty in Australia 5 years post‐procedure
Authors: Hatch Monica , Lilburn Paul , Scott Caroline , Ing Alvin , Langton David 
Published: August 2023

AbstractBackground and ObjectiveOutside clinical trials, there is limited long‐term data following bronchial thermoplasty (BT). In a cohort of real‐world severe asthmatics in an era of biological therapy, we sought to evaluate the safety and efficacy of BT 5 years post‐treatment.MethodsEvery patient treated with BT at two Australian tertiary centres were recalled at 5 years, and evaluated by interview and record review, Asthma Control Questionnaire (ACQ), spirometry and high‐resolution CT Chest. CT scans were interpreted using the modified Reiff and BRICS CT scoring systems for bronchiectasis.ResultsFifty‐one patients were evaluated. At baseline, this cohort had a mean age of 59.0 ± 11.8 years, mean ACQ of 3.0 ± 1.0, mean FEV1 of 55.5 ± 18.8% predicted, and 53% were receiving maintenance oral steroids in addition to triple inhaler therapy. At 5 years, there was a sustained improvement in ACQ scores to 1.8 ± 1.0 (p < 0.001). Steroid requiring exacerbation frequency was reduced from 3.8 ± 3.6 to 1.0 ± 1.6 exacerbations per annum (p < 0.001). 44% of patients had been weaned off oral steroids. No change in spirometry was observed.CT scanning identified minor degrees of localized radiological bronchiectasis in 23/47 patients with the modified Reiff score increasing from 0.6 ± 2.6 at baseline to 1.3 ± 2.5 (p < 0.001). However, no patients exhibited clinical features of bronchiectasis, such as recurrent bacterial infection.ConclusionSustained clinical benefit from BT at 5 years was demonstrated in this cohort of very severe asthmatics. Mild, localized radiological bronchiectasis was identified in a portion of patients without clinical features of bronchiectasis.
Monitoring lower limb biomechanical asymmetry and psychological measures in athletic populations—A scoping review
Authors: Keogh Joshua A. J. , Waddington Emma E. , Masood Zaryan , Mahmood Sobia , Palanisamy Anil C. , Ruder Matthew C. , Karsan Sameena , Bishop Chris , Jordan Matthew J. , Heisz Jennifer J. , Kobsar Dylan 
Published: August 2023

AbstractBackgroundLower limb biomechanics, including asymmetry, are frequently monitored to determine sport performance level and injury risk. However, contributing factors extend beyond biomechanical and asymmetry measures to include psychological, sociological, and environmental factors. Unfortunately, inadequate research has been conducted using holistic biopsychosocial models to characterize sport performance and injury risk. Therefore, this scoping review summarized the research landscape of studies concurrently assessing measures of lower limb biomechanics, asymmetry, and introspective psychological state (e.g., pain, fatigue, perceived exertion, stress, etc.) in healthy, competitive athletes.MethodsA systematic search of MEDLINE, Embase, CINAHL, SPORTDiscus, and Web of Science Core Collections was designed and conducted in accordance with PRISMA guidelines. Fifty‐one articles were included in this review.ResultsSignificant relationships between biomechanics (k = 22 studies) or asymmetry (k = 20 studies) and introspective state were found. Increased self‐reported pain was associated with decreased range of motion, strength, and increased lower limb asymmetry. Higher ratings of perceived exertion were related to increased lower limb asymmetry, self‐reported muscle soreness, and worse jump performance. Few studies (k = 4) monitored athletes longitudinally throughout one or more competitive season(s).ConclusionThis review highlights the need for concurrent analysis of introspective, psychological state, and biomechanical asymmetry measures along with longitudinal research to understand the contributing factors to sport performance and injury risk from biopsychosocial modeling. In doing so, this framework of biopsychosocial preventive and prognostic patient‐centered practices may provide an actionable means of optimizing health, well‐being, and sport performance in competitive athletes.
Genome sequence of
Emydomyces testavorans
type strain 16-2883 (ATCC TSD-145), an onygenalean fungus associated with freshwater aquatic turtle shell lesions
Authors: Hoyer Lois L. , Hogan Elizabeth K. , Adamovicz Laura , Allender Matthew C. , Terio Karen A. , Hernandez Alvaro G. 
Published: August 2023

ABSTRACT

Emydomyces testavorans
is an onygenalean keratinophilic fungus associated with shell and skin lesions in freshwater aquatic turtles. The genome sequence presented here includes five contigs (ranging in size from 2.8 to 9.8 Mb; 31.8 Mb total; 40% GC) and a 92.2-kb mitochondrial genome. The nuclear genome predicted 7,550 genes.
Salivary antibodies induced by BA.4/BA.5-convalescence or bivalent booster Immunoglobulin vaccination protect against novel SARS-COV-2 variants of concern
Authors: Diem Gabriel , Dichtl Stefanie , Zaderer Viktoria , Lass-Flörl Cornelia , Reindl Markus , Lupoli Gaia , Dächert Christopher , Muenchhoff Maximilian , Graf Alexander , Blum Helmut , Keppler Oliver T. , Wilflingseder Doris , Posch Wilfried 
Published: August 2023

ABSTRACT
Currently, SARS-CoV-2 Omicron BA.5 subvariants BF.7 and BQ.1.1 are rapidly emerging worldwide. To evaluate the SARS-CoV-2-neutralizing capacity of sera and saliva from triple vaccinated individuals, either boosted with an adapted bivalent COVID-19 vaccine or recovered from BA.4/BA.5 infection, we analyzed the sensitivity of replication-competent SARS-CoV-2 Omicron subvariants BA.4/5, BQ.1.1 and BF.7 to neutralization. Analysis of SARS-CoV-2-specific IgGs and IgAs showed increased serum IgG titers in the vaccinated group, while the serum and salivary IgA levels were comparable. Similar and efficient serum neutralization against the ancestral strain of SARS-CoV-2 and Omicron BA.4/BA.5 was detected in both cohorts, but critically reduced for BQ.1.1 and BF.7. In contrast, salivary neutralization against BA.4/BA.5 was increased in the convalescent compared to the vaccinated group, while salivary neutralizing capacity against BQ.1.1 and BF.7 was comparable in these groups. Further, personalized protective effects studied in a human 3D respiratory model revealed the importance of salivary protection against different Omicron subvariants.

IMPORTANCE
In BA.4/BA.5-convalescent versus vaccinated groups, salivary neutralization capacity increased against SARS-CoV-2 Omicron BA.4/BA.5. In contrast, it neutralized novel Omicron subvariants BQ.1.1 and BF.7 similarly. Salivary protection against various Omicron subvariants was even more evident when tested in a personalized approach using highly differentiated respiratory human 3D models.
Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance
Authors: Ferguson Katie , Neilson Matthew , Mercer Rachel , King Jenny , Marshall Kelly , Welch Hugh , Tsim Selina , Maskell Nick A , Rahman Najib M , Evison Matthew , Blyth Kevin G 
Published: August 2023

ObjectivesTo assess key elements of the design for Meso-ORIGINS (Mesothelioma Observational study of RIsk prediction and Generation of paired benign-meso tissue samples, Including a Nested MRI Substudy), an ambitious, UK-wide, prospective study that will collect ≥63 matched benign-mesothelioma tissue pairs through longitudinal surveillance and repeat biopsy of patients with asbestos-associated pleural inflammation (AAPI).DesignA multicentre, mixed-methods feasibility study, comprising a prospective observational element, evaluating recruitment feasibility, technical feasibility of repeat local anaesthetic thoracoscopy (LAT) and patient acceptability, and a retrospective cohort study focused on AAPI-mesothelioma evolution rate, informing sample size.Setting4 UK pleural disease centres (February 2019–January 2020).ParticipantsPatients with AAPI (history or typical imaging plus appropriate pleural histology) were eligible for both elements. In August 2019, eligibility for the prospective element was broadened, including addition of radiological AAPI for technical feasibility and patient acceptability endpoints only. Retrospective cases required ≥2 years follow-up.Outcome measuresA prospective recruitment target was set a priori at 27 histological AAPI cases (or 14 in any 6 months). Technical feasibility and patient acceptability were determined at 6-month follow-up by thoracic ultrasound surrogates and questionnaires, respectively. Retrospective malignant pleural mesothelioma evolution rate was defined by proportion (95% CI). Baseline predictors of evolution were identified using logistic regression.Results296 patients with AAPI (39 prospective, 257 retrospective) were recruited/selected. 21/39 prospective recruits were histologically diagnosed (target n=27). Repeat LAT was technically feasible and acceptable in 13/28 (46%) and 24/36 (67%) cases with complete follow-up data. Mesothelioma evolution was confirmed histologically in 36/257 retrospective cases (14% (95% CI 10.3% to 18.8%)) and associated with malignant CT features (OR 4.78 (95% CI 2.36 to 9.86)) and age (OR 1.06 (95% CI 1.02 to 1.12)).ConclusionsOur initial eligibility criteria were too narrow. Meso-ORIGINS will recruit a broader cohort, including prevalent cases, any biopsy type and patients with malignant CT features. A range of rebiopsy techniques will be allowed, accounting for technical and patient factors. The sample size has been reduced to 500.Trial registration numberISRCTN12840870.
Does monoclonal antibody treatment for COVID-19 impact short and long-term outcomes in a large generalisable population? A retrospective cohort study in the USA
Authors: Griffin Daniel , McNeil Chace , Okusa James , Berrent Diana , Guo Yinglong , Daugherty Sarah E 
Published: August 2023

ObjectivesTo explore whether monoclonal antibodies (MAb) administered to high-risk patients with COVID-19 during the first week of illness prevent postacute sequelae of SARS-CoV-2 infection.DesignRetrospective cohort study.SettingUSA.ParticipantsA sample of 3809 individuals who received MAbs and a matched one-to-one comparison group from a set of 327 079 eligible patients who did not receive MAb treatment were selected from a deidentified administrative data set from commercial and Medicare Advantage health plan enrollees in the USA, including claims and outpatient laboratory data.ResultsIndividuals who received MAb were 28% less likely to be hospitalised (HR=0.72, 95% CI 0.58 to 0.89) and 41% less likely to be admitted to the intensive care unit (HR=0.59, 95% CI 0.38 to 0.89) 30 days from SARS-CoV-2 diagnosis compared with individuals who did not receive MAb. A higher proportion of individuals given MAb therapy received care for clinical sequelae in the postacute phase (p=0.018).ConclusionsWhile MAb therapy was associated with benefits in the acute period, the benefit of therapy did not extend into the postacute period and did not reduce risk for clinical sequelae.
Artificial intelligence in detecting dentomaxillofacial fractures in diagnostic imaging: a scoping review protocol
Authors: Diba Silviana Farrah , Sari Dwi Cahyani Ratna , Supriatna Yana , Ardiyanto Igi , Bintoro Bagas Suryo 
Published: August 2023

IntroductionThe dentomaxillofacial (DMF) area, which includes the teeth, maxilla, mandible, zygomaticum, orbits and midface, plays a crucial role in the maintenance of the physiological functions despite its susceptibility to fractures, which are mostly caused by mechanical trauma. As a diagnostic tool, radiographic imaging helps clinicians establish a diagnosis and determine a treatment plan; however, the presence of human factors in image interpretation can result in missed detection of fractures. Therefore, an artificial intelligence (AI) computing system with the potential to help detect abnormalities on radiographic images is currently being developed. This scoping review summarises the literature and assesses the current status of AI in DMF fracture detection in diagnostic imaging.Methods and analysisThis proposed scoping review will be conducted using the framework of Arksey and O’Malley, with each step incorporating the recommendations of Levacet al. By using relevant keywords based on the research questions. PubMed, Science Direct, Scopus, Cochrane Library, Springerlink, Institute of Electrical and Electronics Engineers, and ProQuest will be the databases used in this study. The included studies are published in English between 1 January 2000 and 30 June 2023. Two independent reviewers will screen titles and abstracts, followed by full-text screening and data extraction, which will comprise three components: research study characteristics, comparator and AI characteristics.Ethics and disseminationThis study does not require ethical approval because it analyses primary research articles. The research findings will be distributed through international conferences and peer-reviewed publications.
Digital home monitoring for capturing daily fluctuation of symptoms; a longitudinal repeated measures study: Long Covid Multi-disciplinary Consortium to Optimise Treatments and Services across the NHS (a LOCOMOTION study)
Authors: Mansoubi Maedeh , Dawes Joanna , Bhatia Aishwarya , Vashisht Himanshu , Collett Johnny , Greenwood Darren C , Ezekiel Leisle , O’Connor Daryl , Leveridge Phaedra , Rayner Clare , Read Flo , Sivan Manoj , Tuckerbell Ian , Ward Tomas , Delaney Brendan , Muhlhausen Willie ,   Locomotion consortium, Dawes Helen 
Published: August 2023

IntroductionA substantial proportion of COVID-19 survivors continue to have symptoms more than 3 months after infection, especially of those who required medical intervention. Lasting symptoms are wide-ranging, and presentation varies between individuals and fluctuates within an individual. Improved understanding of undulation in symptoms and triggers may improve efficacy of healthcare providers and enable individuals to better self-manage their Long Covid. We present a protocol where we aim to develop and examine the feasibility and usability of digital home monitoring for capturing daily fluctuation of symptoms in individuals with Long Covid and provide data to facilitate a personalised approach to the classification and management of Long Covid symptoms.Methods and analysisThis study is a longitudinal prospective cohort study of adults with Long Covid accessing 10 National Health Service (NHS) rehabilitation services in the UK. We aim to recruit 400 people from participating NHS sites. At referral to study, 6 weeks and 12 weeks, participants will complete demographic data (referral to study) and clinical outcome measures, including ecological momentary assessment (EMA) using personal mobile devices. EMA items are adapted from the COVID-19 Yorkshire Rehabilitation Scale items and include self-reported activities, symptoms and psychological factors. Passive activity data will be collected through wrist-worn sensors. We will use latent class growth models to identify trajectories of experience, potential phenotypes defined by co-occurrence of symptoms and inter-relationships between stressors, symptoms and participation in daily activities. We anticipate that n=300 participants provide 80% power to detect a 20% improvement in fatigue over 12 weeks in one class of patients relative to another.Ethics and disseminationThe study was approved by the Yorkshire & The Humber—Bradford Leeds Research Ethics Committee (ref: 21/YH/0276). Findings will be disseminated in peer-reviewed publications and presented at conferences.Trial registration numberISRCTN15022307.
The Diverse Mechanisms that Animals Use to Resist Toxins
Authors: Tarvin Rebecca D. , Pearson Kannon C. , Douglas Tyler E. , Ramírez-Castañeda Valeria , Navarrete María José 
Published: August 2023

Biological toxins are entrenched within ecosystems. Thus, animals are often exposed to such toxins, and how they adapt can be a key determinant of their evolutionary trajectories. In this review, we provide an overview of the diversity of toxin resistance mechanisms, with a focus on animals that sequester toxins from their diet and their natural predators and parasites. We propose a structured framework in which to study toxin resistance by recategorizing and reorganizing known mechanisms into avoidance, metabolism, and target categories. Then, using this framework, we review evidence regarding how animals resist four widely studied compounds: tetrodotoxin, batrachotoxin, cardiotonic steroids, and pyrrolizidine alkaloids. Based on the available data, we conclude that toxin resistance and sequestration are interrelated from both ecological and evolutionary perspectives. To conclude, we highlight open questions regarding toxin resistance and review its importance as a field. En los ecosistemas las toxinas de origen biológico son componentes intrínsecos. Por esta razón, los animales se ven expuestos frecuenciamente a dichas toxinas y la forma en que se adaptan puede ser un factor que determina su trayectoria evolutiva. Esta revisión ofrece una visión general de la diversidad de mecanismos de resistencia a toxinas, centrándose en animales que secuestran toxinas de su dieta y en sus depredadores y parásitos naturales. En este texto se propone un marco estructural para estudiar la resistencia a toxinas mediante la recategorización y reorganización de mecanismos conocidos en categorías de: evación, metabolismo y moléculas diana. A continuación, utilizando este marco, revisamos la literatura científica en busca de evidencia sobre cómo los animales resisten a cuatro compuestos ampliamente estudiados: tetrodotoxina, batracotoxina, esteroides cardiotónicos y alcaloides de pirrolizidina. A partir de los datos disponibles, llegamos a la conclusión de que la resistencia y la retención de toxinas están interrelacionadas tanto desde el punto de vista ecológico como evolutivo. Por último, destacamos algunas preguntas abiertas en torno a la resistencia a las toxinas y resaltamos su importancia como campo de estudio en el futuro.
“Telemachising” the Poor Old Woman: Cathleen ni Houlihan “Restaged” at the Martello Tower
Authors: Greer Mick 
Published: August 2023

In 1904, Joyce launched his satirical broadside, “The Holy Office”, attacking the members of the Abbey Theatre. For the young Joyce, it appeared “that mumming company”, run by Yeats and Lady Gregory, had “surrendered to the popular will”. He craved to show how he had broken away from what he considered the folksy, pseudo Irishness of “gold-embroidered Celtic fringes” and those who in their “foolishness . . . sigh back for the good old times” (Occasional, Critical, and Political Writings 28) – times encapsulated, for him, in Cathleen ni Houlihan. Despite telling us that “Cathleen was received with rapturous applause”, Stanislaus Joyce stresses the fact that his brother “was scornful and indignant that Yeats should write such political and dramatic claptrap” (My Brother’s Keeper 187). In “Telemachus”, the more mature Joyce took the opportunity to put his art at the service of his taste for personal and literary revenge through incorporating a brief, parodic take on Yeats and Gregory’ play through the scene with the milk woman. By setting “Cathleen” before his “cracked lookingglass” (Ulysses 6), he was able not only to explore an ironic echo of various tensions between the colonised Irish and the colonising Englishman, but also to ridicule the romanticised view of Ireland presented by much Celtic Revival writing – including drama – at the time Ulysses was set, and that would extend well beyond the time in which it was written and published.
Effect of salt stress on morpho-physiological and anatomical attributes of Salix clones
Authors: Kaur Manpreet , Thakur Sapna , Choudhary O.P. , Kaur Ravneet , Kaila Vineeta , Sharma Jai Pal , Bharti  
Published: August 2023

Abstract
The aim of the study was to assess and quantify the impact of salt stress on key morpho-physiological traits that influence biomass production in Salix clones. In February 2021, a pot experiment was conducted using stem cuttings of five selected Salix clones. The experiment followed a Factorial Completely Randomized Design (CRD) with four replications. The clones were subjected to different levels of NaCl treatments (0, 20, 40, 60, and 80 mM) during the active growth period. The observations on growth and physiological characteristics of clones were recorded at an interval of two months after initiation of salinity treatments i.e., May, July and October. However, the biomass parameters were recorded at the end of experiment. All the growth and biomass traits showed significant reduction with increase in salinity treatments. Among physiological traits significant reduction were observed in total chlorophyll, carotenoids and relative water content, while salinity stress raised the content of proline, total soluble sugar, total soluble protein and Na+/K+ ratio in all the clones. The enzymatic activities of POD and SOD increased in all the clones when subjected to higher levels of salinity stress. On the basis of overall mean performance, clone UHF-03 showed optimum growth and biomass accumulation at 80 mM and was found to be the most tolerant to salinity stress. SEM and EDS mapping confirmed anatomical changes and Na accumulations in the roots and leaves of Salix in response to salinity stress.