bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROGRAMA MINHA CASA MINHA VIDA: Gestão de obras e manifestações patológicas na cidade de Floriano-Piauí
Authors: Eufrasio Maria Catharyna Mousinho , Santos Glauce Barros 
Published: February 2023

Com o propósito de abordar sobre o gerenciamento de obras e projetos na cidade de Floriano/PI, o presente trabalho reúne resultados obtidos por pesquisa que relaciona a gestão de obras e processos construtivos de algumas obras financiadas pelo Programa Minha Casa Minha Vida (MCMV).Esta pesquisa tem como objetivo despertar a população sobre a importância de gestão de obras, relatando sobre as manifestações patológicas mais recorrentes neste espaço, como também a qualidade construtiva das mesmas. Para cumprimento desses objetivos foi realizada revisão bibliográfica através de artigos relacionados ao tema e uma fase investigativa realizada por meio de pesquisa ex-post-facto e observação in loco, onde realizou-se uma lista das manifestações patológicas mais encontradas nas edificações que estão discriminadas por subsistemas, problemas e representatividade. Através dos resultados obtidos nas pesquisas, percebemos que mesmo com todos os benefícios do programa MCMV, as edificações vêm sendo alvo de inúmeras reclamações por parte dos moradores no que tange a qualidade construtiva, bem como o surgimento de patologias ocasionadas por falhas ou ausência do gerenciamento de obras. Percebemos que pelo fato de abranger obras destinadas a população de baixa renda, no Programa MCMV é comum uso de mão de obra desqualificada e materiais de baixa qualidade com a intenção de reduzir custo como também cumprir um prazo para entrega das habitações, dessa forma é importante um bom gerenciamento de obras na qualidade dos serviços, pois observa-se que quando isso não acontece ocorre instabilidade na obra, prejudicando a segurança, os recursos financeiros e a saúde dos moradores.
A IMPORTÂNCIA DA EDUCAÇÃO FISCAL PARA A GESTÃO PÚBLICA E PARA A SOCIEDADE
Authors: Barroso Elisa De Carvalho , Dantas Leonardo Silvério , Araújo Leonardo Batista de , Kalume Mary Correia Moreira , Freitas Ednara Barros de 
Published: February 2023

O presente trabalho aborda a importância da Educação Fiscal como instrumento de aperfeiçoamento da Gestão Pública como também para a formação de uma Sociedade cada vez mais consciente dos seus direitos e deveres. Nesse sentido, propõe-se uma abordagem na difusão dos conhecimentos sobre o funcionamento da administração pública, estimulando o cidadão a refletir sobre a função socioeconômica dos tributos. Para tanto o trabalho foi realizada através de pesquisa bibliográfica com base na revisão da literatura existente em livros e revistas especializadas no assunto publicados no período de 2001 á 2016. Pôde-se constatar a complexidade do funcionamento da máquina pública, bem como, a necessidade de Incentivar continuamente a participação e o acompanhamento, pela sociedade, desde o processo de planejamento governamental até a aplicação dos recursos públicos. O estudo e a disseminação da Educação Fiscal são importantes principalmente para criar condições para uma relação harmoniosa entre o Estado e a sociedade.
GRAVIDEZ NA ADOLESCÊNCIA: IMPLICAÇÃO SOCIAL
Authors: Barros Letícia Rodrigues , Santos Glauce Barros 
Published: February 2023

INTRODUÇÃO: A adolescência é o período de transição da infância para a idade adulta, é nela que há o descobrimento do corpo e dos órgãos sexuais. Nessa etapa os adolescentes não pensam nas consequências dos seus atos, não usam métodos contraceptivos, acarretando assim gravidez indesejada, IST’s (Infecções Sexualmente Transmissíveis) sem dizer que os índices de gravidez na adolescência vêm aumentando cada vez mais no Brasil (MOREIRA, ET AL, 2007). OBJETIVO: Descrever as relações evidenciadas quanto a gravidez na adolescência como uma experiência desejada ou não e suas possíveis consequências. METODOLOGIA: Tratou-se de uma pesquisa exploratória e descritiva, utilizando-se a revisão bibliográfica. RESULTADO/DISCUSSÃO: Os artigos analisados revelaram que a gravidez na adolescência é mais pesquisada na área da saúde e da psicologia e Serviço Social, sendo assim considerada como um problema de saúde pública. Muitos pais não conversam com seus filhos sobre sexo, as vezes por falta de tempo, desinteresse ou mesmo por constrangimento, obrigando-os a procurarem outras fontes de conhecimentos, como: internet, tv ou experiências de amigos e com isso terminam não cumprindo o seu papel de educador. Os adolescentes não têm muito conhecimento de como se usa os métodos contraceptivos, acarretando assim gravidez e IST’s (Infecções Sexualmente Transmissíveis) (MOREIRA, ET AL, 2007). Meninas de nível econômico menos favorecido relatam que ter um filho é uma benção divina e que a maternidade dá um reconhecimento, o de ser mulher. Já as de nível econômico médio, pensam mais no futuro, que não é a hora certa e que a gravidez pode comprometer o futuro (DIAS; TEIXEIRA, 2007). CONCLUSÃO: Sabemos que muitas adolescentes veem a maternidade como um presente, outras percebe-se como forma de comprometimento do futuro. Nesse sentido, a equipe de saúde junto com o psicólogo e o assistente social tende a trabalhar na prevenção da gravidez, formulando novas propostas junto com as adolescentes para se trabalhar diversos temas ,propondo palestras, oficinas educativas e aulas interativas para que as jovens fiquem mais informadas a respeito da sexualidade, gravidez, IST’s (Infecções Sexualmente Transmissíveis), métodos contraceptivos para que assim possam ter consciência das possíveis consequências geradas a partir de uma gravidez indesejada ou uma gravidez prematura.
Construindo uma carreira acadêmica e profissional
Authors: Saraiva Louise Cristina Freitas 
Published: February 2023

É com muito orgulho que onde chego falo que estudei na FAESF, pois foi o lugar em que eu pude não somente ter uma profissão, mas que me abriu novos horizontes e que me ensinou a olhar o mundo de uma forma diferente.Desde o início, sabia que a jornada não seria fácil, mas graças aos mestres que passaram pelo meu caminho e às oportunidades que foram surgindo me mostraram que eu estava no caminho certo. E foi devido a isso que logo no início do curso, obtive meu primeiro contato com a vida profissional, quando consegui um estágio no Conselho Regional de Farmácia e pude conhecer um pouco da parte burocrática da profissão farmacêutica. Em seguida, fui selecionada para um estágio no Laboratório Sobral, onde vivenciei uma experiência incrível ao ter a oportunidade de passar por diversos setores e trabalhar ao lado de grandes profissionais. Assim, findados os dois anos deste estágio e ainda no último semestre da faculdade, fui contratada como funcionária da empresa como analista de pesquisa e desenvolvimento e, após formada, como farmacêutica no mesmo departamento. Pouco tempo depois, veio a aprovação no mestrado em Ciências Farmacêuticas da UFPI e em uma especialização em Gestão em Saúde na UESPI. Desse modo, acabei optando por dar continuidade à carreira acadêmica e mergulhar na luta pelo meu grande sonho, que é ser professora universitária. Hoje me sinto realizada por ter chegado até aqui, mesmo sabendo que tudo é ainda uma sementinha. Só tenho a agradecer à FAESF e aos professores pelo apoio e incentivo que sempre me deram, grande parte do que conquistei foi graças a vocês.
PARP inhibitors as first-line maintenance therapy in ovarian cancer: recommendations from an expert panel from Brazil
Authors: Calabrich Aknar FC , Assad Daniele Xavier , Dal-Molin Graziela , Melo Andreia C , Nogueira-Rodrigues Angelica , Kalil Karime , Guimarães Andrea PG , Almeida Michelle Samora , de-Azevedo Carla Rameri , de-Freitas Daniela , Morelle Alessandra Menezes , Leite Ana Carolina , Crosara Marcela , Nunes João Soares , Signorini Poliana , Cronemberger Eduardo , Cossetti Rachel , Guindalini Rodrigo , Paulino Eduardo , Maluf Fernando C 
Published: February 2023

ABSTRACTTo report consensus recommendations on the current role of poly(ADP-ribose) polymerase (PARP) inhibitors in the front-line management of patients with epithelial ovarian cancer (EOC) in the healthcare setting of Brazil. The expert panel convened in March 2021 and comprised 20 medical oncologists focus on gynecological oncology. The panel answered anonymously and based on scientific evidence a total of 67 questions. The panel reached consensus (at least 75% of votes for the same recommendation) or majority vote (50% to 74.9%) for the majority of questions that addressed: (1) who and when to test for BRCA mutations or homologous recombination deficiency (2) what test should be used; (3) when should maintenance PARP inhibitor therapy be indicated; (4) which PARP inhibitor should be used; (5) when should bevacizumab be combined; and (6) toxicity management. The current recommendations may help Brazilian practitioners to improve the use of PARP inhibitors in front-line management of EOC.
Risk Perception of Pineapple Farmers in the Context of Covid-19 in Kerala
Authors: Arshad N. , Vijayan Aswathy , Lazarus T. Paul , Durga A. R. , Suresh A. , Gopinath Pratheesh P. 
Published: February 2023

Aims : To assess the risk perception of pineapple farmers in the context of Covid 19.
Place and Duration of the Study: Muvattupuzha block panchayat in Ernakulam district in Kerala between September 2021 to September 2022.
Methodology: The data relating to the study were collected during September 2021 from 120 pineapple farmers, using a well-structured interview schedule. Based on a four-point Likert scale, a Standardized Covid -19 Risk Perception Index (SCovRPI) was developed to assess the risk perception against fourteen identified risks faced by pineapple farmers during Covid 19. Farmers were asked to score the risks based on their level of perception.
Results: Realisation of low price, restrictions in transportation, low demand for pineapple in market, disruption in farming activities and non-availability of adequate hired labour are the major risks perceived by pineapple farmers during Covid 19.
Conclusion: findings of the study are relevant for policymakers as they work to seek remedial measures that enhance the living standards and resilience of pineapple farmers.
Diffuse Large B Cell Lymphoma of the Maxilla. A Rare Case Report Emphasizing Differential Diagnosis of Maxillary Involvement
Authors: Sutare Ajay , Parihar Ajay Pratap Singh , Reddy Prashanthi , Varsha A. C. 
Published: February 2023

Aims: Report a rare case of Diffuse large B cell lymphoma (DLBCL) of the maxilla which is difficult to diagnose clinically and radiographically with a wide array of differential diagnosis lists.
Presentation of Case: A case of a 16-year male with well-defined swelling in the posterior region of the right maxilla associated with pain, paraesthesia, and abnormal mobility of teeth which mimicked a localized periodontal abscess. The clinical diagnosis of DLBCL poses a challenge opening a wide array of false diagnostic impressions.
Discussion: Traditionally lymphoma is classified into Hodgkin’s (HL) and non-Hodgkin’s lymphoma (NHL) and NHL involves the extra-nodal site including the gastrointestinal tract, central nervous system, skin as well as in the head and neck area involving waldeyer’s ring, buccal mucosa, tongue, maxilla, and mandible
Conclusion: The diagnosis of DLBCL may get delayed with a wide range of differentials in the jaw. A false diagnosis like periapical pathology or other benign lesions would delay the treatment plan. Clinically any lesion suspicious of malignancy in the jaw requires the attention of clinicopathological and radiographic correlation with special diagnostic techniques like immunohistochemistry.
Characterizing Moral Injury and Distress in US Military Surgeons Deployed to Far-Forward Combat Environments in Afghanistan and Iraq
Authors: Ryu Madeline Y. , Martin Matthew J. , Jin Alexander H. , Tabor Holly K. , Wren Sherry M. 
Published: February 2023

ImportanceMoral injury and distress (MID), which occurs when individuals have significant dissonance with their belief system and overwhelming feelings of being powerless to do what is believed to be right, has not been explored in the unique population of military surgeons deployed far forward in active combat settings. Deployed military surgeons provide care to both injured soldiers and civilians under command-driven medical rules of engagement (MROE) in variably resourced settings. This practice setting has no civilian corollary for comparison or current specific tool for measurement.ObjectiveTo characterize MID among military surgeons deployed during periods of high casualty volumes through a mixed-methods approach.Design, Setting, and ParticipantsThis qualitative study using convergent mixed methods was performed from May 2020 to October 2020. Participants included US military surgeons who had combat deployments to a far-forward role 2 treatment facility during predefined peak casualty periods in Iraq (2003-2008) and Afghanistan (2009-2012), as identified by purposeful snowball sampling. Data analysis was performed from October 2020 to May 2021.Main Outcomes and MeasuresMeasure of Moral Distress for Healthcare Professionals (MMD-HP) survey and individual, semistructured interviews were conducted to thematic saturation.ResultsThe total cohort included 20 surgeons (mean [SD] age, 38.1 [5.2] years); 16 (80%) were male, and 16 (80%) had 0 or 1 prior deployment. Deployment locations were Afghanistan (11 surgeons [55%]), Iraq (9 surgeons [45%]), or both locations (3 surgeons [15%]). The mean (SD) MMD-HP score for the surgeons was 104.1 (39.3). The primary thematic domains for MID were distressing outcomes (DO) and MROE. The major subdomains of DO were guilt related to witnessing horrific injuries; treating pregnant women, children, and US soldiers; and second-guessing decisions. The major subdomains for MROE were forced transfer of civilian patients, limited capabilities and resources, inexperience in specialty surgical procedures, and communication with command. Postdeployment manifestations of MID were common and affected sleep, medical practice, and interpersonal relationships.Conclusions and RelevanceIn this qualitative study, MID was ubiquitous in deployed military surgeons. Thematic observations about MID, specifically concerning the domains of DO and MROE, may represent targets for further study to develop an evaluation tool of MID in this population and inform possible programs for identification and mitigation of MID.
A Competition, Benchmark, Code, and Data for Using Artificial Intelligence to Detect Lesions in Digital Breast Tomosynthesis
Authors: Konz Nicholas , Buda Mateusz , Gu Hanxue , Saha Ashirbani , Yang Jichen , Chłędowski Jakub , Park Jungkyu , Witowski Jan , Geras Krzysztof J. , Shoshan Yoel , Gilboa-Solomon Flora , Khapun Daniel , Ratner Vadim , Barkan Ella , Ozery-Flato Michal , Martí Robert , Omigbodun Akinyinka , Marasinou Chrysostomos , Nakhaei Noor , Hsu William , Sahu Pranjal , Hossain Md Belayat , Lee Juhun , Santos Carlos , Przelaskowski Artur , Kalpathy-Cramer Jayashree , Bearce Benjamin , Cha Kenny , Farahani Keyvan , Petrick Nicholas , Hadjiiski Lubomir , Drukker Karen , Armato Samuel G. , Mazurowski Maciej A. 
Published: February 2023

ImportanceAn accurate and robust artificial intelligence (AI) algorithm for detecting cancer in digital breast tomosynthesis (DBT) could significantly improve detection accuracy and reduce health care costs worldwide.ObjectivesTo make training and evaluation data for the development of AI algorithms for DBT analysis available, to develop well-defined benchmarks, and to create publicly available code for existing methods.Design, Setting, and ParticipantsThis diagnostic study is based on a multi-institutional international grand challenge in which research teams developed algorithms to detect lesions in DBT. A data set of 22 032 reconstructed DBT volumes was made available to research teams. Phase 1, in which teams were provided 700 scans from the training set, 120 from the validation set, and 180 from the test set, took place from December 2020 to January 2021, and phase 2, in which teams were given the full data set, took place from May to July 2021.Main Outcomes and MeasuresThe overall performance was evaluated by mean sensitivity for biopsied lesions using only DBT volumes with biopsied lesions; ties were broken by including all DBT volumes.ResultsA total of 8 teams participated in the challenge. The team with the highest mean sensitivity for biopsied lesions was the NYU B-Team, with 0.957 (95% CI, 0.924-0.984), and the second-place team, ZeDuS, had a mean sensitivity of 0.926 (95% CI, 0.881-0.964). When the results were aggregated, the mean sensitivity for all submitted algorithms was 0.879; for only those who participated in phase 2, it was 0.926.Conclusions and RelevanceIn this diagnostic study, an international competition produced algorithms with high sensitivity for using AI to detect lesions on DBT images. A standardized performance benchmark for the detection task using publicly available clinical imaging data was released, with detailed descriptions and analyses of submitted algorithms accompanied by a public release of their predictions and code for selected methods. These resources will serve as a foundation for future research on computer-assisted diagnosis methods for DBT, significantly lowering the barrier of entry for new researchers.
Risk Prediction Models for Cardiotoxicity of Chemotherapy Among Patients With Breast Cancer
Authors: Kaboré Elisé G. , Macdonald Conor , Kaboré Ahmed , Didier Romain , Arveux Patrick , Meda Nicolas , Boutron-Ruault Marie-Christine , Guenancia Charles 
Published: February 2023

ImportanceCardiotoxicity is a serious adverse effect that can occur in women undergoing treatment for breast cancer. Identifying patients who will develop cardiotoxicity remains challenging.ObjectiveTo identify, describe, and evaluate all prognostic models developed to predict cardiotoxicity following treatment in women with breast cancer.Evidence ReviewThis systematic review searched the Medline, Embase, and Cochrane databases up to September 22, 2021, to include studies developing or validating a prediction model for cardiotoxicity in women with breast cancer. The Prediction Model Risk of Bias Assessment Tool (PROBAST) was used to assess both the risk of bias and the applicability of the prediction modeling studies. Transparency reporting was assessed with the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) tool.FindingsAfter screening 590 publications, we identified 7 prognostic model studies for this review. Six were model development studies and 1 was an external validation study. Outcomes included occurrence of cardiac dysfunction (echocardiographic parameters), heart failure, and composite clinical outcomes. Model discrimination, measured by the area under receiver operating curves or C statistic, ranged from 0.70 (95% IC, 0.62-0.77) to 0.87 (95% IC, 0.77-0.96). The most common predictors identified in final prediction models included age, baseline left ventricular ejection fraction, hypertension, and diabetes. Four of the developed models were deemed to be at high risk of bias due to analysis concerns, particularly for sample size, handling of missing data, and not presenting appropriate performance statistics. None of the included studies examined the clinical utility of the developed model. All studies met more than 80% of the items in TRIPOD checklist.Conclusions and RelevanceIn this systematic review of the 6 predictive models identified, only 1 had undergone external validation. Most of the studies were assessed as being at high overall risk of bias. Application of the reporting guidelines may help future research and improve the reproducibility and applicability of prediction models for cardiotoxicity following breast cancer treatment.
Research on surface defect detection and fault diagnosis of mechanical gear based on R‐CNN
Authors: Guo Wu 
Published: February 2023

AbstractGears are the basic units in modern power systems. The detection and diagnosis of surface defects and faults in gears are conducive to improving product quality, ensuring the safety of mechanical equipment, and reducing maintenance costs. However, the accuracy of manual and traditional automated target detection algorithms is not satisfactory. Therefore, this research uses the R‐CNN algorithm for gear detection, improves its non‐maximum suppression algorithm and multi‐task loss function, and obtains the improved Faster R‐CNN algorithm. The test was carried out on the built data set. The actual measurement shows that the recall rate of the improved Faster R‐CNN is up to 0.951 and the lowest is 0.816. Its AP value is as low as 0.677 and as high as 0.858, and the mAP value is 0.843. Horizontal comparison, the comparison results show that the mAP of Faster R‐CNN is 0.80 1, second only to R‐CNN among the tested algorithms, and 8.83% higher than the original Faster R‐CNN. Under the condition of AP@0.5:0.95, among all the tested algorithms, its AR index is the highest at 54.3, and the detection speed is 18 FPS/s. Although the detection speed has decreased, the detection and recognition accuracy has been significantly improved, which provides feasibility for the R‐CNN series of algorithms new optimization directions. The research provides a better automatic detection method for product quality inspection in gear manufacturing industry.
Cell Membranes from Tumor‐Tropic MSCs Screened by a Microfluidic Chip for Drug Nanoparticles Encapsulation and Cancer Targeted Therapy
Authors: Song Yizuo , Shou Xin , Sheng Bo , Mei Jie , Shi Keqing , Shang Luoran , Zhu Xueqiong 
Published: February 2023

AbstractNanoparticles (NPs)‐based drug carriers are effective in reducing systemic toxicity and drug resistance for chemotherapy, and an emerging trend focuses on integrating cell membranes with nanomedicines for tumor targeting. Mesenchymal stem cells (MSCs) are promising candidates due to their unique tropism toward cancer cells, yet the tumor‐tropic abilities can differ for MSCs sourced from different tissues. Here, a multichannel microfluidic chip to screen different sourced MSCs with the greatest tropism toward cervical cancer cells is developed. Based on this, the cell membranes from the chorionic plate‐derived MSC are isolated and membrane‐camouflaged platinum prodrug composite NPs for cervical cancer treatment are prepared. Results demonstrate that the composite NPs can effectively target tumor sites and have a therapeutic effect both in vitro and in vivo. It is believed that the present microfluidic platform is a powerful tool for cell screening and tumor‐on‐a‐chip studies, and the derived nanodelivery system represents the great value of cell membrane‐camouflaged nanomedicine for targeted cancer therapy.
Polyampholyte‐Based Polymer Hydrogels for the Long‐Term Storage, Protection and Delivery of Therapeutic Proteins
Authors: Rajan Robin , Kumar Nishant , Zhao Dandan , Dai Xianda , Kawamoto Keiko , Matsumura Kazuaki 
Published: February 2023

AbstractProtein storage and delivery are crucial for biomedical applications such as protein therapeutics and recombinant proteins. Lack of proper protocols results in the denaturation of proteins, rendering them inactive and manifesting undesired side effects. In this study, polyampholyte‐based (succinylated ε‐poly‐l‐lysine) hydrogels containing polyvinyl alcohol and polyethylene glycol polymer matrices to stabilize proteins are developed. These hydrogels facilitated the loading and release of therapeutic amounts of proteins and withstood thermal and freezing stress (15 freeze–thaw cycles and temperatures of −80 °C and 37 °C), without resulting in protein denaturation and aggregation. To the best of our knowledge, this strategy has not been applied to the design of hydrogels constituting polymers, (in particular, polyampholyte‐based polymers) which have inherent efficiency to stabilize proteins and protect them from denaturation. Our findings can open up new avenues in protein biopharmaceutics for the design of materials that can store therapeutic proteins long‐term under severe stress and safely deliver them.