bluuebunny/crossref_metadata_2025_split huggingface dataset:
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation
Authors: Ma Cunying , Wang Dandan , Tian Zhuangfei , Gao Wenrong , Zang Yichen , Qian Lilin , Xu Xia , Jia Jihui , Liu Zhifang 
Published: June 2023

AbstractThe reversible post-translational modifications of protein ubiquitination and deubiquitination play a crucial regulatory role in cellular homeostasis. Deubiquitinases (DUBs) are responsible for the removal of ubiquitin from the protein substrates. The dysregulation of the DUBs may give rise to the occurrence and development of tumors. In this study, we investigated the gastric cancer (GC) data from the TCGA and GEO databases and found that ubiquitin-specific protease USP13 was significantly up-regulated in GC samples. The higher expression of USP13 was associated with the worse prognosis and shorter overall survival (OS) of GC patients. Enforced expression of USP13 in GC cells promoted the cell cycle progression and cell proliferation in an enzymatically dependent manner. Conversely, suppression of USP13 led to GC cell cycle arrest in G1 phase and the inhibition of cell proliferation. Nude mouse experiments indicated that depletion of USP13 in GC cells dramatically suppressed tumor growth in vivo. Mechanistically, USP13 physically bound to the N-terminal domain of cyclin D1 and removed its K48- but not K63-linked polyubiquitination chain, thereby stabilizing and increasing cyclin D1. Furthermore, re-expression of cyclin D1 partially reversed the cell cycle arrest and cell proliferation inhibition induced by USP13 depletion in GC cells. Additionally, USP13 protein abundance was positively correlated with the protein level of cyclin D1 in human GC tissues. Taken together, our data demonstrate that USP13 deubiquitinates and stabilizes cyclin D1, thereby promoting cell cycle progression and cell proliferation in GC. These findings suggest that USP13 might be a promising therapeutic target for the treatment of GC.
Detection of approximal caries in digital radiographs before and after correction for attenuation and visual response. An in vitro study.
Authors: Li G , Yoshiura K , Welander U , Shi X Q , McDavid W D 
Published: June 2023

OBJECTIVE To evaluate if digital compensation for exponential attenuation and the characteristics of the human visual system improves the diagnosis of approximal caries from digital radiographs. MATERIAL AND METHODS Forty premolar teeth were mounted in plaster blocks. Radiographs of the teeth were exposed with the Dixi digital intraoral system employing a Prostyle Intra dental X-ray unit (Planmeca Oy, Helsinki, Finland). Thirteen radiographs were then processed to compensate for the exponential attenuation and for the characteristic of the human visual system using equations presented in the paper. Ten observers were asked to diagnose approximal caries in all radiographs. ROC analyses were performed. The teeth were subsequently sectioned for histological validation of the lesions. The areas under ROC curves of original and processed radiographs were compared and analysed using Wilcoxon's signed-ranks test. RESULTS There were significant diagnostic differences between the two types of radiographs (all lesions P=0.005. enamel P=0.028, and dentine P=0.050). CONCLUSION Digital radiographs processed to compensate for exponential attenuation and the characteristics of the human visual system significantly improves the diagnosis of approximal caries in vitro.
Generalizable and efficient cross‐domain person re‐identification model using deep metric learning
Authors: Faghih Imani Saba Sadat , Fouladi‐Ghaleh Kazim , Aghababa Hossein 
Published: June 2023

AbstractMost of the successful person re‐ID models conduct supervised training and need a large number of training data. These models fail to generalise well on unseen unlabelled testing sets. The authors aim to learn a generalisable person re‐identification model. The model uses one labelled source dataset and one unlabelled target dataset during training and generalises well on the target testing set. To this end, after a feature extraction by the ResNext‐50 network, the authors optimise the model by three loss functions. (a) One loss function is designed to learn the features of the target domain by tuning the distances between target images. Therefore, the trained model will be more robust to overcome the intra‐domain variations in the target domain and generalises well on the target testing set. (b) One triplet loss is used which considers both source and target domains and makes the model learn the inter‐domain variations between source and target domain as well as the variations in the target domain. (c) Also, one loss function is for supervised learning on the labelled source domain. Extensive experiments on Market1501 and DukeMTMC re‐ID show that the model achieves a very competitive performance compared with state‐of‐the‐art models and also it requires an acceptable amount of GPU RAM compared to other successful models.
Multi‐component condition monitoring method for wind turbine gearbox based on adaptive noise reduction
Authors: Chen Yang , Liu Yongqian , Han Shuang , Qiao Yanhui 
Published: June 2023

AbstractWind turbine gearbox condition monitoring (C&M) is a key technology to promote wind farm maintenance cost reduction and power generation improvement. Existing gearbox C&M methods usually adopt the component‐by‐component modelling approach. Firstly, this approach is inefficient in modelling; secondly, due to the thermal conduction effect, abnormalities in one gearbox component usually affect other components, making it difficult to identify the source of faults. To solve these problems, a normal behaviour model (NBM) combining data adaptive noise reduction and an improved variational auto‐encoder (VAE) is proposed, which can monitor the operational condition of multiple components of one gearbox simultaneously and takes into account the correlation between components when warning of the specific abnormal component. As verified by practical cases, the method balances the modelling accuracy and efficiency of the multi‐component NBM and achieves effective early warning and accurate localization of gearbox abnormalities. The proposed model has lower false alarm and missed alarm rates compared to other single‐component and multi‐component NBMs.
Effects of heat pump scheduling on low‐voltage grids using a receding horizon control strategy
Authors: Haendel Michael , Hug Gabriela , Klobasa Marian 
Published: June 2023

AbstractHeat pumps (HPs) are a promising option for decarbonizing the residential heating sector. Their use leads to an increased demand for electricity, which can burden the grid in uncontrolled operation, while controlled HPs can provide additional flexibility to the system. In this paper, the integration of HPs through a receding horizon approach into a power market model is presented to study the behavior of HPs considering electricity market prices and network constraints of a low‐voltage grid. In a case study with centralized and self‐consumption optimized control strategies, the effects of HPs are analyzed. Furthermore, the authors investigate how the aggregation of several households into energy communities affects the system. The results show that for the considered grid, the additional power demand of HPs is usually uncritical and a strictly cost‐minimizing operation is often possible from a grid perspective. Typically, critical grid situations occur only at times of high PV feed‐in with low HP flexibility. The formation of energy communities compared to individual households differs primarily in the allocation of cost savings to individual consumers. The difference in the impact of the two control strategies on the grid is negligible in this case.
Complete X-ray census of M dwarfs in the solar neighborhood
Authors: Caramazza M. , Stelzer B. , Magaudda E. , Raetz St. , Güdel M. , Orlando S. , Poppenhäger K. 
Published: June 2023

Context. X-ray emission is the most sensitive diagnostic of magnetic activity in M dwarfs and, hence, of the dynamo in low-mass stars. Moreover it is crucial for quantifying the influence of the stellar irradiation on the evolution of planet atmospheres.
Aims. We have embarked in a systematic study of the X-ray emission in a volume-limited sample of M dwarf stars to explore the full range of activity levels present in their coronae. We look to obtain a better understanding of the conditions in their outer atmospheres and their possible impact on the circumstellar environment.
Methods. Based on a recent catalog of Gaia objects within 10 pc from the Sun, we identified all its stars with spectral types between M0 and M4 and we carried out a systematic search for X-ray measurements of this sample. To this end, we used both archival data from ROSAT, XMM-Newton, and the ROentgen Survey with an Imaging Telescope Array (eROSITA) on board the Russian Spektrum-Roentgen-Gamma mission, as well as our own dedicated XMM-Newton observations. To make inferences on the properties of the M dwarf corona, we compared the range of their observed X-ray emission levels to the flux radiated by the Sun from different types of magnetic structures: coronal holes, background corona, active regions, and cores of active regions. In this work, we focus on the properties of stars with the faintest X-ray emission.
Results. At the current state of our project, with more than 90% of the 10 pc M dwarf sample observed in the X-ray, there is only one star that has had no detections: GJ 745 A. With an upper limit luminosity of log Lx (erg s−1) < 25.4 and an X-ray surface flux of log FX,SURF (erg cm−2 s−1) < 3.6, GJ 745 A defines the lower boundary of the X-ray emission level for M dwarfs. Together with its proper motion companion (GJ 745 B), it is the only star in this volume-complete sample located in the range of X-ray surface flux that corresponds to the faintest solar coronal structures, namely: coronal holes. The fact that the ultra-low X-ray emission level of GJ 745 B (log Lx (erg s−1) = 25.6 and log FX,SURF (erg cm−2 s−1) = 3.8) is entirely attributed to flaring activity indicates that while its corona is dominated by “holes,” at least one magnetically active structure is present. This structure determines the total X-ray brightness and the coronal temperature of the star.
Social Drivers of COVID-19 Disease Severity in Pregnant Patients
Authors: Mckinney Jennifer , Salmanian Bahram , Grace Rebecca , Moufarrij Sara , Sangi-Haghpeykar Haleh , Eppes Catherine , Gandhi Manisha 
Published: June 2023

Objective While coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had global impact in all populations, certain groups of patients have experienced disproportionate rates of morbidity and mortality. The purpose of this study was to assess the relationship between COVID-19 disease severity, demographic variables, race and ethnicity, and social determinants of health among pregnant patients in a diverse urban population.
Study Design A retrospective analysis was performed of all pregnant patients diagnosed with COVID-19 at two urban tertiary care centers in Houston, TX between March and August 2020. Maternal demographic, COVID-19 illness criteria, and delivery characteristics were collected. The Centers for Disease Control and Prevention Social Vulnerability Index (SVI) and COVID-19 Community Vulnerability Index (CCVI) were obtained based on a patients' census tract of residence. Analyses compared persons with asymptomatic, mild, or severe-critical disease at diagnosis.
Results A total of 317 persons tested positive for COVID-19 during this time period. Asymptomatic persons were more likely to be diagnosed at later gestational ages, but there were no other differences in baseline maternal characteristics. Persons with more severe disease had greater social vulnerability specifically for housing and transportation than those with mild disease (mean SVI [standard error]: 0.72 [0.06] vs. 0.58 [0.2], p = 0.03). Total SVI, total CCVI, and other themed SVI and CCVI indices were not significantly different between groups.
Conclusion In this cohort of pregnant persons infected with SARS-CoV-2, an association was shown between disease severity and increased vulnerability in living conditions and transportation. Drivers of the pandemic and COVID-19 outcomes are complex and multifactorial, and likely change over time. However, continued efforts to accurately identify and measure social determinants of health in medicine will likely help identify geographic areas and patient populations that are at risk of higher disease burden. This could facilitate preventative and mitigation measures in these areas in future disaster or pandemic situations.
Key Points
Exposure to Prolonged Rupture of Membranes at Term Increases the Risk for Ventilatory Support in Uninfected Neonates
Authors: Tramontano Anna L. , Menichini Daniela , Lazzarin Sara , Sponzilli Alessandra , Zinani Isotta , Facchinetti Fabio , Berardi Alberto 
Published: June 2023

Objective The effects of prolonged rupture of membranes (ROMs) on perinatal outcomes are still unclear, and it remains controversial for the management of those labors. This study aims to evaluate how the exposure of pregnant women to a prolonged ROM (≥ 24 hours) affects maternal and neonatal outcomes.
Study Design This retrospective cohort study included singleton pregnant women at term delivering between January 2019 and March 2020 in a tertiary hospital. All relevant sociodemographic, pregnancy, and perinatal variables (maternal age, prepregnancy body mass index, labor, and delivery outcomes) were collected anonymously. Data were compared between the “ROM < 24 hours” and “ROM ≥ 24 hours” study groups.
Results A total of 2,689 dyads were included in the study and divided according to their ROM-delivery time: ROM <24 hours (2,369 women, 88.1%), and ROM ≥ 24 hours (320 women, 11.9%). Maternal baseline characteristics were comparable except for the rate of nulliparous women, which was significantly higher among patients with ROM ≥ 24 hours. No significant differences were found regarding infectious neonatal outcomes. However, mechanical ventilation and continuous positive airway pressure were more common among neonates born after ROM ≥ 24 hours. The greater likelihood of neonatal respiratory distress was also confirmed among infants born to Group-B Streptococcus-negative women with ROM ≥ 24 hours (15 out of 267 neonates, 5.6% vs. 52 out of 1,529 with ROM < 24 hours, 3.4%, p = 0.04).
Conclusion According to the actual expectant policy, prolonged ROM is associated with an increased risk of respiratory support in noninfected neonates. Further investigations are required to explain such an association.
Key Points
First-principles investigation on the high-pressure phase transitions and elastic constants of chromium nitrides
Authors: Hao Xiaofeng , Bai Yan , Li Bin , Shi Zhixiang 
Published: June 2023

We performed first-principles calculations on the structural and electronic properties of chromium nitrides under high pressure. Based on crystal structure predictions, we identified several novel chromium nitrogen compounds and pressure-induced phase transitions in the Cr–N system from ambient pressure to 200 GPa. The dynamic stable compounds—CrN2, CrN6, and Cr2N3—are studied through both electronic and phononic calculations. This work provides a theoretical basis for the phase transition of Cr–N compounds under different pressures, points out the direction of future research on Cr–N systems, and may stimulate the synthesis of superhard and high energy density materials in the future.
Nonlinear stability of self-gravitating massive fields. A wave-Klein–Gordon model
Authors: LeFloch Philippe G , Ma Yue 
Published: June 2023

Abstract
In recent years, significant progress has been made in understanding the global evolution of self-gravitating massive matter in the small-perturbative regime near Minkowski spacetime. To investigate the interaction between a Klein–Gordon equation and Einstein’s field equations, we developed a new approach called the Euclidean-hyperboloidal foliation method. This method involves constructing a spacetime foliation that is well-suited for deriving precise decay estimates for wave and Klein–Gordon equations in curved spacetime. In this article, we provide an overview of our method and present a complete proof for a wave-Klein–Gordon model that captures some of the key challenges associated with the Einstein-matter system.
Nonsingular black holes from conformal symmetries
Authors: Cadoni M , Sanna A P 
Published: June 2023

AbstractWe derive the form of the metric for static, nonsingular black holes with a de Sitter core, representing a deformation of the Schwarzschild solution, by assuming that the gravitational sources describe a flow between two conformal points, at small and great distances. The resulting black-hole metric turns out to be a particular case of the Fan & Wang metric, whose parameters have been recently constrained by using the data of the S2 star orbits around the galactic center SgrA∗.
Fatigue fracture mechanics in gold-based MEMS notched specimens: experimental and numerical study
Authors: Pistorio Francesca , Somà Aurelio 
Published: June 2023

Abstract
The characterization of fatigue fracture mechanics in gold-MEMS notched specimens is presented in this work. A test microstructure with a central notched specimen is specifically designed and built to perform on-chip fatigue test. The central specimen undergoes cyclic loading due to the application of alternating voltage. The variation in the microstructure deflection is measured using an optical profilometer and is attributed to the crack growth in the gold material, causing the variation in the specimen stiffness. The occurrence of pull-in condition is used as a fracture detector, then the fracture of the specimen can be recognized without performing scanning electron microscope inspections during the fatigue test. Crack propagation in the test specimen is simulated through a coupled-field electromechanical fracture finite element model and the resulting crack path is compared to the experimental measurments performed with scanning electron microscope analyses. Finally, Paris’ law is applied and the number of cycles to failure is computed by exploiting the results of the fracture model and experimental measurements. Both experimental and numerical results demonstrate that the notch acts as a stress and strain raiser, fostering crack nucleation, and that the linear elastic fracture mechanics theory is still valid to describe crack propagation in micro-size samples.
Accelerated measurement of electrical resistivity and Seebeck coefficient for thin-layer thermoelectric materials
Authors: Yao Lei , Yang Dongwang , Tao Qirui , Zhang Zhengkai , Luo Jiangfan , Yan Yonggao , Tang Xinfeng 
Published: June 2023

Abstract
Compared to the diffusion couple and thin film material library, the thin-layer (also known as thick film) material library with discrete compositions is more suitable for the screening of high performance thermoelectric (TE) materials. However, there are few apparatuses for high throughput characterizing TE properties of thin-layer material library. In this work, a tool with high reliability for effectively and quickly measuring electrical resistivity and Seebeck coefficient has been successfully developed via using a combination of van der Pauw and quasi-steady state method. The relative measurement errors of the electrical resistivity and Seebeck coefficient are less than 10%, comparable to commercial ZEM-3 equipment. The time to measure the electrical resistivity and Seebeck coefficient at a single temperature point is 4 min, saving up to 61.8% of the time compared to ZEM-3. This will contribute to the screening of novel TE materials from the thin-layer TE material libraries in the future.
Atomic simulation of the effect of supersonic fine particle bombardment process parameters on the mechanical properties of polycrystalline γ-TiAl alloy
Authors: Yu Zhaoliang , Cao Hui , Zhou Baocheng , Liu Jianhui , Feng Ruicheng , Wang Jingqi , Yang Wenle 
Published: June 2023

Abstract

γ-TiAl alloys are the most promising lightweight high-temperature structural materials, but the materials often fail from the surface, which is mainly attributed to the stress state of the material surface. In this paper, the orthogonal experiment method and molecular dynamics modeling are used to choose a set of the best process parameters for supersonic fine particle bombardment (SFPB). Furthermore, by determining the optimal process parameters, this study examines the influence of residual stress distribution on the mechanical properties of the material under various process conditions. The simulation results reveal that the residual stress distribution is minimally impacted by particle radius, nonetheless, maintaining a moderate level of compressive residual stress within a specific range can substantially augment both the tensile strength and indentation hardness. An increase in the number of particles results in a more uniform distribution of surface residual stresses. Conversely, an increase in the number of impacts causes stress concentration to intensify at the particle’s contact point, and thus a deeper distribution of residual stress is observed. This study illustrates how the mechanical properties of polycrystalline γ-TiAl alloy are affected by the process parameters of SFPB in terms of atomic size in order to develop and select the optimal SFPB parameters.
Spin-dependent thermoelectric transport properties of Cr-doped blue phosphorene
Authors: Shi H L , Yang J , Han Q Z , Ren Y H , Zhao Y H , He S Y , Gong L J , Jiang Z T 
Published: June 2023

Abstract
We systematically investigate the thermoelectric (TE) properties of the Cr-doped blue phosphorene (blue-P) along the armchair and zigzag directions. First, we find the semiconducting band structure of the blue-P will become spin-polarized due to the Cr-doping, and can be seriously changed by the doping concentration. Then we show the Seebeck coefficient, the electronic conductance, the thermal conductance, and the figures of merit ZTs are all dependent on the transport directions and doping concentration. However, two pairs of the peaks of the charge and spin ZTs can be always observed with the low-height (high-height) pair on the side of the negative (positive) Fermi energy. In addition, at temperature 300 K the extrema of the charge (spin) ZTs of the blue-P along the two directions are kept to be larger than 22 (90) for the different doping concentrations and will be further enhanced at lower temperature. Therefore, we believe the Cr-doped blue-P should be a versatile high-performance TE material which may be used in the fields of the thermorelectrics and spin caloritronics.