bluuebunny/crossref_metadata_2025_split huggingface dataset:
New criteria for existence of solutions for equilibrium problems
Authors: Balaj Mircea , Castellani Marco , Giuli Massimiliano 
Published: February 2023

AbstractEquilibrium problems provide a mathematical framework which includes optimization, variational inequalities, fixed point and saddle point problems, and noncooperative games as particular cases. In this paper sufficient conditions for the existence of solutions of an equilibrium problem are given by weakening the assumption of quasiconvexity of the involved equilibrium bifunction. The existence of solutions is established both in presence of compactness of the feasible set as well with a coercivity assumption. The results are obtained in an infinite dimensional setting, and they are based on the so called finite solvability property which is weaker than the recently introduced finite intersection property and in turn, weaker than most common cyclic and proper quasimonotonicity. Some examples are presented to illustrate the various cases in which other existence results for equilibrium problems do not apply. Finally, applications to the solution of quasiequilibrium problems, quasioptimization problems and generalized quasivariational inequalities are discussed.
Multi-scale Modelling of Shear Stress on the Syncytiotrophoblast: Could Maternal Blood Flow Impact Placental Function Across Gestation?
Authors: Lee Tet Chuan , Moulvi Ali , James Joanna L. , Clark Alys R. 
Published: February 2023

Abstract
The placenta is a critical fetal exchange organ, with a complex branching tree-like structure. Its surface is covered by a single multinucleated cell, the syncytiotrophoblast, which bathes in maternal blood for most of pregnancy. Mechanosensing protein expression by the syncytiotrophoblast at term suggests that shear stress exerted by maternal blood flow may modulate placental development and function. However, it is not known how the mechanosensitive capacity of the syncytiotrophoblast, or the shear stress it experiences, change across gestation. Here, we show that the syncytiotrophoblast expresses both mechanosensitive ion channels (Piezo 1, Polycystin 2, TRPV6) and motor proteins associated with primary cilia (Dynein 1, IFT88, Kinesin 2), with higher staining for all these proteins seen in late first trimester placentae than at term. MicroCT imaging of placental tissue was then used to inform computational models of blood flow at the placentone scale (using a porous media model), and at the villous scale (using explicit flow simulations). These two models are then linked to produce a combined model that allows the variation of shear stress across both these scales simultaneously. This combined model predicts that the range of shear stress on the syncytiotrophoblast is higher in the first-trimester than at term (0.8 dyne/cm2 median stress compared to 0.04 dyne/cm2) when considering both these scales. Together, this suggests that the nature of blood flow through the intervillous space, and the resulting shear stress on the syncytiotrophoblast have important influences on placental morphogenesis and function from early in pregnancy.
Deep learning: survey of environmental and camera impacts on internet of things images
Authors: Kaur Roopdeep , Karmakar Gour , Xia Feng , Imran Muhammad 
Published: February 2023

AbstractInternet of Things (IoT) images are captivating growing attention because of their wide range of applications which requires visual analysis to drive automation. However, IoT images are predominantly captured from outdoor environments and thus are inherently impacted by the camera and environmental parameters which can adversely affect corresponding applications. Deep Learning (DL) has been widely adopted in the field of image processing and computer vision and can reduce the impact of these parameters on IoT images. Albeit, there are many DL-based techniques available in the current literature for analyzing and reducing the environmental and camera impacts on IoT images. However, to the best of our knowledge, no survey paper presents state-of-the-art DL-based approaches for this purpose. Motivated by this, for the first time, we present a Systematic Literature Review (SLR) of existing DL techniques available for analyzing and reducing environmental and camera lens impacts on IoT images. As part of this SLR, firstly, we reiterate and highlight the significance of IoT images in their respective applications. Secondly, we describe the DL techniques employed for assessing the environmental and camera lens distortion impacts on IoT images. Thirdly, we illustrate how DL can be effective in reducing the impact of environmental and camera lens distortion in IoT images. Finally, along with the critical reflection on the advantages and limitations of the techniques, we also present ways to address the research challenges of existing techniques and identify some further researches to advance the relevant research areas.
Widespread chromosomal rearrangements preceded genetic divergence in a monitor lizard, Varanus acanthurus (Varanidae)
Authors: Dobry Jason , Wapstra Erik , Stringer Emily J. , Gruber Bernd , Deakin Janine E. , Ezaz Tariq 
Published: February 2023

AbstractChromosomal rearrangements are often associated with local adaptation and speciation because they suppress recombination, and as a result, rearrangements have been implicated in disrupting gene flow. Although there is strong evidence to suggest that chromosome rearrangements are a factor in genetic isolation of divergent populations, the underlying mechanism remains elusive. Here, we applied an integrative cytogenetics and genomics approach testing whether chromosomal rearrangements are the initial process, or a consequence, of population divergence in the dwarf goanna, Varanus acanthurus. Specifically, we tested whether chromosome rearrangements are indicators of genetic barriers that can be used to identify divergent populations by looking at gene flow within and between populations with rearrangements. We found that gene flow was present between individuals with chromosome rearrangements within populations, but there was no gene flow between populations that had similar chromosome rearrangements. Moreover, we identified a correlation between reduced genetic variation in populations with a higher frequency of homozygous submetacentric individuals. These findings suggest that chromosomal rearrangements were widespread prior to divergence, and because we found populations with higher frequencies of submetacentric chromosomes were associated with lower genetic diversity, this could indicate that polymorphisms within populations are early indicators of genetic drift.
Evaluation of a multifaceted medication review in older patients in the outpatient setting: a before-and-after study
Authors: Zwietering N.A. , Linkens A. E. M. J. H. , van der Kuy P. H. M. , Cremers H. , van Nie-Visser N. , Hurkens K. P. G. M. , Spaetgens Bart 
Published: February 2023

Abstract
Background
The prevalence of medication-related emergency department visits and acute hospital admissions in older patients is rising due to the ageing of the population and increasing prevalence of multimorbidity and associated polypharmacy.

Aim
To explore whether a combined medication review performed in the outpatient setting reduces the number of medication-related emergency department visits and hospital (re)admissions.

Method
All consecutive patients visiting the geriatric outpatient clinic underwent a multifaceted medication review (i.e. evaluation by at least a geriatrician, and/or pharmacist and use of clinical decision support system). Subsequently, we analysed the number of, and reason for, emergency department visits, acute hospital admissions and readmissions in the year prior to and the year following the index-date (date of first presentation and medication review).

Results
A multifaceted medication review reduced the number of potentially medication-related emergency department visits (38.9% vs. 19.6%, p < 0.01), although the total number of ED visits or acute hospital admissions per patient in the year before and after medication review did not differ.

Conclusion
A multifaceted medication review performed in the outpatient clinic reduced the number of potentially medication-related emergency department visits and could therefore reduce negative health outcomes and healthcare costs.
Adding Modified Buckwheat Sprouts to an Atherogenic Diet — the Effect on Selected Nutritional Parameters in Rats
Authors: Molska Marta , Reguła Julita , Świeca Michał 
Published: February 2023

Abstract
The germinated seeds of many plants are a natural source of substances that can be used to supplement food and increase its functionality. The seeds’ metabolism may be modified during germination to produce specific health-promoting compounds. Fagopyrum esculentum Moench is a rich source of nutrients. Buckwheat seeds modified during germination may be helpful as an additive to new functional food products with anti-atherogenic properties. However, their effect and safety should be assessed in in vivo studies. The aim of the study was to evaluate the effect that adding modified buckwheat sprouts (Fagopyrum esculentum Moench) to an atherogenic (high-fat) diet has on the morphology and digestibility parameters of rats. Buckwheat seeds were modified by adding the probiotic strain of the yeast Saccharomyces cerevisiae var. boulardii. The study was carried out on 32 Wistar rats, and digestibility and blood counts were assessed during the experiment. There was no evidence of an adverse effect on the animals' weight gain and nutritional efficiency. However, the influence of diets with freeze-dried buckwheat sprouts on digestibility and morphological parameters was noticed. Fat digestibility registered a statistically significant decrease in the groups fed a high-fat diet with the addition of sprouts. The study shows a new direction in the use of buckwheat sprouts.
Parametric mapping of QTL for resistance to European canker in apple in ‘Aroma’ × ‘Discovery’
Authors: Skytte af Sätra Jonas , Odilbekov Firuz , Ingvarsson Pär K. , van de Weg Eric , Garkava-Gustavsson Larisa 
Published: February 2023

AbstractResistance to European canker (Neonectria ditissima) in apple is currently one of the most important breeding targets for commercial production in Sweden. Previous research has identified significant genetic variation in susceptibility to the disease, with the local Swedish cultivar ‘Aroma’ considered as one of the most resistant cultivars. Identification of genetic regions underlying the resistance of this cultivar would be a valuable tool for future breeding. Thus, we performed Bayesian quantitative trait loci (QTL) mapping for resistance to European canker in a full-sib family of ‘Aroma’ × ‘Discovery’. Mapping was performed with the area under the disease progression curves (AUDPCs) from all seven (AUDPC_All7) and the first four assessments (AUDPC_First4), and three parameters of a sigmoid growth model for lesion length. As a scale for the effect of the different parameters, historic phenotypic data from screenings of a genetically diverse germplasm was compiled and re-analyzed. The parametrization of the data on lesion growth increased the number of QTL that could be identified with high statistical power, and provided some insight into their roles during different stages of disease development in the current experimental setup. Five QTL regions with strong or decisive evidence were identified on linkage groups 1, 8, 15, and 16. The QTL regions could be assigned to either of the parameters lesion length at the first assessment (‘LL_A1’), the maximal lesion growth rate (lesion length doubling time, ‘t_gen’), and the lesion length at girdling (‘LL_G’). Three of these QTL were traced along the pedigrees of some known relatives of the FS family, and discussed in relation to future crosses for breeding and genetic research.
Spatial distribution of metabolites in the retina and its relevance to studies of metabolic retinal disorders
Authors: Bonelli Roberto , Woods Sasha M. , Lockwood Sarah , Bishop Paul N. , Khan Kamron N. , Bahlo Melanie , Ansell Brendan R. E. , Fruttiger Marcus 
Published: February 2023

Abstract
Introduction
The primate retina has evolved regional specialisations for specific visual functions. The macula is specialised towards high acuity vision and is an area that contains an increased density of cone photoreceptors and signal processing neurons. Different regions in the retina display unique susceptibility to pathology, with many retinal diseases primarily affecting the macula.

Objectives
To better understand the properties of different retinal areas we studied the differential distribution of metabolites across the retina.

Methods
We conducted an untargeted metabolomics analysis on full-thickness punches from three different regions (macula, temporal peri-macula and periphery) of healthy primate retina.

Results
Nearly half of all metabolites identified showed differential abundance in at least one comparison between the three regions. Furthermore, mapping metabolomics results from macula-specific eye diseases onto our region-specific metabolite distributions revealed differential abundance defining systemic metabolic dysregulations that were region specific.

Conclusions
The unique metabolic phenotype of different retinal regions is likely due to the differential distribution of different cell types in these regions reflecting the specific metabolic requirements of each cell type. Our results may help to better understand the pathobiology of retinal diseases with region specificity.
Effect of microorganisms on degradation of fluopyram and tebuconazole in laboratory and field studies
Authors: Podbielska Magdalena , Kus-Liśkiewicz Małgorzata , Jagusztyn Bartosz , Szpyrka Ewa 
Published: February 2023

Abstract
Nowadays, chemical pesticides are the most widespread measure used to control crop pests and diseases. However, their negative side effects prompted the researchers to search for alternative options that were safer for the environment and people. Pesticide biodegradation by microorganisms seems to be the most reasonable alternative. The aim of the laboratory studies was to assess the influence of Bacillus subtilis and Trichoderma harzianum, used separately and combined together, on fluopyram and tebuconazole degradation. In field studies, the degradation of fluopyram and tebuconazole after the application of the biological preparation in apples was investigated. The results from the laboratory studies show that the greatest decomposition of fluopyram and tebuconazole was observed in tests with T. harzianum in a range of 74.3–81.5% and 44.5–49.2%, respectively. The effectiveness of fluopyram degradation by B. subtilis was 7.5%, while tebuconazole inhibited bacterial cell growth and no degradation was observed. The mixture of microorganisms affected the degradation of fluopyram in a range of 8.3–24.1% and tebuconazole in a range of 6.1–23.3%. The results from the field studies show that degradation increased from 3.1 to 30.8% for fluopyram and from 0.4 to 14.3% for tebuconazole when compared to control samples. The first-order kinetics models were used to simulate the residue dissipation in apples. For the determination of pesticide residues, the QuEChERS method for apple sample preparation was performed, followed by GC–MS/MS technique. Immediately after the treatments, the maximum residue level (MRL) values for tebuconazole were exceeded, and it was equal to 100.7% MRL for the Red Jonaprince variety and 132.3% MRL for the Gala variety. Thus, preharvest time is recommended to obtain apples in which the concentration of pesticides is below the MRL and which can be recognized as safe for humans.
The role of teachers in a sustainable university: from digital competencies to postdigital capabilities
Authors: Markauskaite Lina , Carvalho Lucila , Fawns Tim 
Published: February 2023

AbstractAn increase in online and hybrid education during and after the Covid-19 pandemic has rapidly accelerated the infiltration of digital media into mainstream university teaching. Global challenges, such as ecological crises, call for further radical changes in university teaching, requiring an even richer convergence of ‘natural,’ ‘human’ and ‘digital’. In this paper, we argue that this convergence demands us to go beyond ‘the great online transition’ and reframe how we think about university, teachers’ roles and their competencies to use digital technologies. We focus on what it takes to be a teacher in a sustainable university and consider emerging trends at three levels of the educational ecosystem—global developments (macro), teachers’ local practices (meso), and daily activities (micro). Through discussion of examples of ecopedagogies and pedagogies of care and self-care, we argue that teaching requires a fluency to embrace different ways of knowing and collective awareness of how the digital is entwined with human practices within and across different levels of the educational ecosystem. For this, there is a need to move beyond person-centric theorisations of teacher digital competencies towards more holistic, ecological conceptualisations. It also requires going beyond functionalist views of teachers’ roles towards enabling their agentive engagement with a future-oriented, sustainable university mission.
Evolution of Martensite Tetragonality in High-Carbon Steels Revealed by In Situ High-Energy X-Ray Diffraction
Authors: Kohne Thomas , Fahlkrans Johan , Stormvinter Albin , Maawad Emad , Winkelmann Aimo , Hedström Peter , Borgenstam Annika 
Published: February 2023

Abstract
The martensitic transformation was studied by in situ and ex situ experiments in two high-carbon, 0.54 and 0.74 wt pct C, steels applying three different cooling rates, 15 °C/s, 5 °C/s, and 0.5 °C/s, in the temperature range around Ms, to improve the understanding of the evolution of martensite tetragonality c/a and phase fraction formed during the transformation. The combination of in situ high-energy X-ray diffraction during controlled cooling and spatially resolved tetragonality c/a determination by electron backscatter diffraction pattern matching was used to study the transformation behavior. The cooling rate and the different Ms for the steels had a clear impact on the martensitic transformation with a decrease in average tetragonality due to stronger autotempering for a decreasing cooling rate and higher Ms. A slower cooling rate also resulted in a lower fraction of martensite at room temperature, but with an increase in fraction of autotempered martensite. Additionally, a heterogeneous distribution of martensite tetragonality was observed for all cooling rates.
Development of High-Resolution Nuclear Emulsion Plates for Synchrotron X-Ray Topography Observation of Large-Size Semiconductor Wafers
Authors: Harada Shunta , Nishigaki Taketo , Kitagawa Nobuko , Ishiji Kotaro , Hanada Kenji , Tanaka Atsushi , Morishima Kunihiro 
Published: February 2023

AbstractCharacterization of defects in semiconductor wafers is essential for the development and improvement of semiconductor devices, especially power devices. X-ray topography (XRT) using synchrotron radiation is a powerful methods used for defect characterization. To achieve detailed characterization of large-size semiconductor wafers by synchrotron XRT, we have developed nuclear emulsion plates reaching a high-resolution and wide dynamic range. We have shown that higher-resolution XRT images could be obtained using emulsions with smaller iodobromide crystals, and demonstrated clear observation of threading edge dislocations in a SiC epitaxial layer having small contrast. Furthermore, we demonstrated XRT image acquisition for almost all of a 150-mm SiC wafer with one plate. Our development will contribute to advances in electronic materials, especially in the field of power electronics, in which defect characterization is important for improving the performance and yield of devices.
Inflammatory biomarkers of ischemic stroke
Authors: Tirandi Amedeo , Sgura Cosimo , Carbone Federico , Montecucco Fabrizio , Liberale Luca 
Published: February 2023

AbstractIschemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.
Evaluation of Different Copper Sources in Nile Tilapia Diets: Growth, Body Indices, Hematological Assay, Plasma Metabolites, Immune, Anti-Oxidative Ability, and Intestinal Morphometric Measurements
Authors: EL-Erian Mohamed A. , Ibrahim Mohamed S. , Salem Shimaa M. R. , Mohammady Eman Y. , El-Haroun Ehab R. , Hassaan Mohamed S. 
Published: February 2023

Abstract
The goal of the current study was to compare how well Nile tilapia, Oreochromis niloticus, utilized copper (Cu) as bulk and nano sources by evaluating fish growth, body indices, hematological assays, plasma metabolites, immune and anti-oxidative abilities, and intestinal morphometric measurements. The basal diet served as a control, with no Cu added, whereas the experimental diets were formed by adding bulk-Cu and nano-Cu to the basal diet to keep Cu levels at 3 and 6 mg kg−1, respectively, in both Cu sources. Tilapia (9.10 ± 0.014 g) were fed the control diet and four experimental diets for 12 weeks. Results indicated that growth, feed utilization, and body indices demonstrated a substantial improvement (P ≤ 0.05) in tilapia that received a diet containing 3 and 6 Nano-Cu mg kg−1 diet, compared to the performance of fish that received diets containing 3 and 6 Bulk-Cu mg kg−1 diet and the control diet. Villi height, villi width, absorption area of villous (AAV), and mucosal to serosal amplification ratio (MSR) values demonstrated a substantial increase (P ≤ 0.05) in tilapia fed 3 and 6 mg kg−1 Nano-Cu compared to the values observed in fish fed the control and Bulk-Cu supplemented diets. Fish fed Bulk-Cu recorded the highest (P ≤ 0.05) hemoglobin concentration in those fed 6 mg kg−1 compared to 3 mg kg−1. Hematocrit value considerably improved (P ≤ 0.05) by supplementation of Cu, whereas the highest significant value demonstrated in fish provided 6 mg/kg−1 Nano-Cu. A fish-fed diet containing 3 mg kg−1 Nano-Cu revealed the best (P ≤ 0.05) values of plasma albumin, total protein, and globulins. Plasma HDL-C highest concentrations (P ≤ 0.05) were reported in fish fed diet supplemented with 6 mg/kg−1 either Bulk or Nano Cu, whereas values of plasma TG and VLDL-C declined as Cu supplementation level increased either from Bulk or Nano source. Also, the best (P ≤ 0.05) values of CAT and GPX were seen in fish given diet supplemented with 6 Nano-Cu mg/kg−1. Fillets of fish-fed Nano-Cu-supplemented diets showed a marked decline (P ≤ 0.05) in moisture and fat contents, while crude protein, ash, and Cu contents considerably increased in the fillet by dietary supplementation of Nano-Cu at both levels 3 and 6 mg kg−1. In conclusion, the supplemental diets with 3 or 6 Nano-Cu mg/kg−1 enhanced growth, feed utilization, body indices, fillet nutrient composition, hematological assay, plasma metabolites, immune, antioxidant activities, and intestinal morphometry of Nile tilapia.