bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentiment analysis of Indonesian tweets on COVID-19 and COVID-19 vaccinations
Authors: Kalanjati Viskasari Pintoko , Hasanatuludhhiyah Nurina , d'Arqom Annette , Arsyi Danial H. , Marchianti Ancah Caesarina Novi , Muhammad Azlin , Purwitasari Diana 
Published: August 2023

Background: Sentiments and opinions regarding COVID-19 and the COVID-19 vaccination on Indonesian-language Twitter are scarcely reported in one comprehensive study, and thus were aimed at our study. We also analyzed fake news and facts, and Twitter engagement to understand people’s perceptions and beliefs that determine public health literacy. Methods: We collected 3,489,367 tweets data from January 2020 to August 2021. We analyzed factual and fake news using the string comparison method. The difflib library was used to measure similarity. The user's engagement was analyzed by averaging the engagement metrics of tweets, retweets, favorites, replies, and posts shared with sentiments and opinions regarding COVID-19 and COVID-19 vaccination. Result: Positive sentiments on COVID-19 and COVID-19 vaccination dominated, however, the negative sentiments increased during the beginning of the implementation of restrictions on community activities (PPKM). The tweets were dominated by the importance of health protocols (washing hands, keeping distance, and wearing masks). Several types of vaccines were on top of the word count in the vaccine subtopic. Acceptance of the vaccination increased during the studied period, and the fake news was overweighed by the facts. The tweets were dynamic and showed that the engaged topics were changed from the nature of COVID-19 to the vaccination and virus mutation which peaked in the early and middle terms of 2021. The public sentiment and engagement were shifted from hesitancy to anxiety towards the safety and effectiveness of the vaccines, whilst changed again into wariness on an uprising of the delta variant. Conclusion: Understanding public sentiment and opinion can help policymakers to plan the best strategy to cope with the pandemic. Positive sentiments and fact-based opinions on COVID-19, and COVID-19 vaccination had been shown predominantly. However, sufficient health literacy levels could yet be predicted and sought for further study.
An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line
Authors: Al-Roshdi Maha , Stevenson Thomas , Görtler Franziska , Grellscheid Sushma Nagaraja 
Published: August 2023

Background: Senescent cells are characterized by an arrest in proliferation. In addition to replicative senescence resulting from telomere exhaustion, sub-lethal genotoxic stress resulting from DNA damage, oncogene activation or mitochondrial dysfunction also elicits a senescence phenotype. Methods: Senescence was induced in an osteocarcinoma cancer cell line in response to sub-lethal doses of a genotoxic chemotherapeutic agent, followed by quantitative SWATH proteomics and RNA-seq analyses. Results: We present here an integrative multi-omic analysis of proteomic and RNA-seq from proliferating and senescent osteosarcoma cells. Senescence is a controlled program affecting a wide variety of biological processes with some core hallmarks of senescence as well as cell type specific changes. Conclusions: This study presents an integrated analysis and makes available both RNA-seq and proteomic data from proliferating and senescent cells in appropriate FAIR data repositories to aid reuse by the community.
Estimation of prevalence of risk factor of hypertension among population of Wardha district between age group of 35-60 years: a study protocol.
Authors: Dadmal Amruta , Mude Gaurav 
Published: August 2023

A serious medical condition known as hypertension or elevated blood pressure significantly rises the risk of brain, heart, kidney, and other medical conditions. It is the most common cardiovascular disease globally and is now recognized as a major health issue that needs to be addressed. It serves as a warning sign for serious illnesses including myocardial infarction, stroke and renal failure. An estimated 46% of the population with hypertension are not aware of the condition they have. Only 42% of those diagnosed with hypertension receive a diagnosis and treatment. 21% (1/5) of the population who have hypertension have it under control. Around the world, high blood pressure (HBP) is a main cause of early death. Knowledge on the prevalence of risk factors for hypertension is needed because there are relatively few community-based research projects on the condition. The objective of this study is to assess the prevalence of hypertension risk factor in the Wardha district in the state of Maharashtra in western India. A cross-sectional study will be performed. The study’s strength lies in the use of a standardized risk factor check list, which will ensure consistency in data collection and minimize bias. The use of a large sample size (165 patients) will also improve the precision of study and increase the generalization of the result.
Investigating how the electronic and optical properties of a novel cubic inorganic halide perovskite, Sr3NI3 are affected by strain
Authors: Shanto Md. Abul Bashar , Rahman Md. Ferdous , Islam Md. Rasidul , Ghosh Avijit , Azzouz-Rached Ahmed , Albalawi Hind , Mahmood Q. 
Published: August 2023

Background: Inorganic Perovskite materials have sparked the attention of the solar technology sector due to their remarkable structural, optical, and electrical capabilities. In the realm of efficient LEDs, inorganic perovskites have displayed considerable promise, showcasing various benefits such as exceptional color purity, the ability to adjust emission wavelengths, and cost-effective fabrication methods. Methods: The study extensively investigated the bandgap, density of states, electron charge density, structural properties, dielectric properties, loss function, and absorption coefficient of Sr3NI3 under strain using first-principles density functional theory (DFT). Results: At the Gamma (Γ) point, the unstrained flat structure of Sr3NI3 exhibits a direct band gap of 0.733 eV. Observing the spin-orbital coupling (SOC) effect reduces the bandgap to 0.711 eV in Sr3NI3 perovskite. Compressive strain minimizes the prevalence of the structure's bandgap, whereas tensile strain causes a slight elevation. The optical properties of this material, including the dielectric functions, absorption coefficient, reflectivity, and electron loss function, exhibit its excellent absorption capacity in the visible area because of its band characteristics. Conclusions: The research indicates that as the amount of compressive strain rises, the peak values of the dielectric constant of Sr3NI3 shift towards lower photon energy (redshift); meanwhile, when tensile strain is executed, it displays the behavior of altered photon energy with an increase towards higher energy levels (blueshift). Thus, the potential of utilizing Sr3NI3 perovskite in solar cells for energy production and light management is considered promising.
Symptoms of sexuality-related disorders in the group of overweight and obese women
Authors: Fuksiewicz Anna , Kostecka Barbara , Kot Emilia , Jodko-Modlińska Aleksandra , Kucharska Katarzyna 
Published: August 2023

Cel pracyCelem badania była ocena obecności objawów zaburzeń związanych z seksualnością (ZzS) w grupie kobiet z nadwagą i otyłością oraz związku tych objawów z nieadaptacyjnymi postawami i przekonaniami na temat jedzenia, nasileniem objawów lękowych i depresyjnych, spożywaniem alkoholu, trudnościami w regulacji emocjonalnej oraz jakością życia.MetodaGrupę badaną (GB) stanowiły 44 kobiety z nadwagą/otyłością, grupę kontrolną (GK) – 51 kobiet z prawidłową masą ciała w wieku 18-40 lat. Zastosowano: Kwestionariusz Seksuologiczny, Test Postaw Wobec Jedzenia, Kwestionariusz Przekonań Dotyczących Jedzenia, Test Rozpoznawania Problemów Alkoholowych, Szpitalną Skalę Lęku i Depresji oraz Kwestionariusz Oceny Jakości Życia.WynikiW GB zaobserwowano większą ilość objawów ZzS, w tym objawów dysfunkcji seksualnych i objawów zaburzeń preferencji seksualnych w porównaniu do GK. Pomimo licznych podobieństw, w GB zaobserwowano więcej istotnych statystycznie korelacji między ZzS a badanymi zmiennymi, szczególnie w obszarze trudności w regulacji emocjonalnej. W GB istotna dla ZzS okazała się obecność negatywnych i permisywnych przekonań żywieniowych, a w GK – przekonań pozytywnych. Ilość objawów ZzS okazała się ponadto istotnym predyktorem jakości życia.WnioskiOtrzymane wyniki wskazują na związek nadmiernej masy ciała z większą ilością objawów ZzS oraz związek objawów ZzS z poziomem zmiennych klinicznych i jakością życia. Niezbędne są dalsze badania eksplorujące mechanizmy zaobserwowanych zależności.
Baclofen - a great chance or danger - discussion of poisoning based on research
Authors: Świątek Gabriela , Tkaczyk Rafał , Radoniewicz–Tchórz Anna , Sosnowska Weronika , Brzozowska Aleksandra , Tomkiewicz Maria , Tomczyk Jakub , Tomkiewicz Maciej , Trusz Kornelia , Wanat Iwona 
Published: August 2023

Introduction and purpose: Baclofen is a derivative of γ-aminobutyric acid (GABA). It is a spasmolytic drug that reduces skeletal muscle tension and is used in spasticity. Despite its many positive functions, its use is associated with a risk of side effects. The aim of this work is to gain a better understanding of baclofen and to highlight the toxicity and dangers of its misuse.
Material and methods: The study was retrospective in nature. It used an analysis of the records of 11648 intoxications in patients hospitalised from 01.04.2013 to 01.04.2023 in the Clinical Toxicology and Cardiology Department of the Stefan Cardinal Wyszyński Provincial Hospital in Lublin, from which a group of baclofen intoxicated patients (T55), consisting of 19 cases, was distinguished.
Results: The study population consisted of 10 women (52.63%) and 9 men (47.37%), aged between 16 and 83 years. The largest group consisted of patients aged up to 30 years - 9 patients (47.37%). The majority of patients - 11 patients (59.89%) were in a severe condition. An overwhelming number reported intentional poisoning - 16 cases (84.21%), including five suicide attempts (31.25%). Patients took other drugs and medicines in addition to baclofen. The most common was ethanol - 8 people (42.11%), followed by NSAIDs - 5 people (26.32%).
Conclusions: In order to prevent complications following the use of baclofen, it is very important to educate patients, their family members and the general public about the mechanism of action of the drug itself, its function on the body and the risks of taking it. Prophylactic measures and education on how to deal with poisoning situations are necessary, as they are entirely preventable with immediate diagnosis and treatment.
Medicinal plants in burns treatment – a systematic review
Authors: Łopuszyńska Inga , Adamowicz Dominik , Rudziński Patrtyk , Wosińska Alicja , Meliksetian Astrik , Pazik Dorota , Kosecka Katarzyna , Cieślik Aleksandra , Jargieło Anna , Kosieradzka Karolina 
Published: August 2023

Introduction and aim. The World Health Organization (WHO) reports that around 11 million people experience burn injuries each year.1,2 Burn injuries occur when tissue damage is caused by various factors such as UV radiation, heat, chemicals, or electric current.3,4 While burns primarily affect the skin, they can also extend to deeper tissues like bones or muscles. When the skin is burned, its vital functions, including protection against the external environment, pathogens, and evaporation, are compromised.1 The appropriate treatment method must be chosen based on the burn stage, the patient's condition, and the cause. The aim of this paper is to provide a comprehensive review based on literature, concerning superficial burns and sunburns treatment, with a focus on nature-derived topical treatment methods.
Material and methods. PubMed database was searched for the following terms: “burns”, “burn treatment”, “aloe vera”, “sunburn”, “centella asiatica”, “climate change”, “wound healing” for the articles published between 2005-2023 and written in the English language.
Conclusion. Herbal-derived compounds, with their diverse mechanisms of action, antibacterial activity, and safety profiles present a competitive alternative to conventional treatment of burns and sunburns, however, there are still not enough clinical trials to assess the effectiveness and safety profiles of nature-derived compounds.
Robust Dynamic Assortment Optimization in the Presence of Outlier Customers
Authors: Chen Xi , Krishnamurthy Akshay , Wang Yining 
Published: August 2023

Robust Dynamic Assortment Optimization Assortment optimization with choice model estimation and learning has been studied extensively in the data-driven revenue management literature. Existing methods and analysis, however, do not take into consideration the fact that some customers arriving at certain time periods might exhibit outlier purchasing behaviors. The work of Chen et al. studies dynamic assortment optimization in the presence of outlier customers modeled by an [Formula: see text]-contamnination model. The impact of outlier customers on the revenue performance of an algorithm is analyzed and discussed.
Multifocal multilevel diffractive lens by wavelength multiplexing
Authors: Jia Wei , Lin Dajun , Menon Rajesh , Sensale-Rodriguez Berardi 
Published: August 2023

Flat lenses with focal length tunability can enable the development of
highly integrated imaging systems. This work explores machine learning
to inverse design a multifocal multilevel diffractive lens (MMDL) by
wavelength multiplexing. The MMDL output is multiplexed in three color
channels, red (650 nm), green (550 nm), and blue
(450 nm), to achieve varied focal lengths of 4 mm,
20 mm, and 40 mm at these three color channels,
respectively. The focal lengths of the MMDL scale significantly with
the wavelength in contrast to conventional diffractive lenses. The
MMDL consists of concentric rings with equal widths and varied
heights. The machine learning method is utilized to optimize the
height of each concentric ring to obtain the desired phase
distribution so as to achieve varied focal lengths multiplexed by
wavelengths. The designed MMDL is fabricated through a direct-write
laser lithography system with gray-scale exposure. The demonstrated
singlet lens is miniature and polarization insensitive, and thus can
potentially be applied in integrated optical imaging systems to
achieve zooming functions.
Multicenter Longitudinal Observational Study Pharmaceuticals Alflutop in Russia (message 2)
Authors: Lila A. M. , Taskina E. A. , Alekseeva L. I. , Kashevarova N. G. 
Published: August 2023

Osteoarthritis (OA) is one of the most important medical and social problems due to the steady increase in morbidity and disability. Prevention, management of risk factors, and early treatment of OA are critical.Objective of the ISKRA study was to evaluate the efficacy of Alflutop in patients with OA of different locations and/or low back pain (LBP) with or without concomitant diseases.Material and methods. We selected 11,136 patients with OA of specific localizations aged 50 to 72 years. The duration of the study ranged from 20 to 31 days, and the number of visits was 2 (B1 and B2). Alflutop was prescribed 1 ml intramuscularly (IM) daily No. 20 or 2 ml IM every other day No. 10.The efficacy of therapy was determined by the time of onset of clinical effect (pain reduction, as assessed by the patient), the dynamics of pain intensity in the studied joint during movement and/or LBP according to the visual analogue scale (VAS), the assessment of quality of life according to the EQ-5D questionnaire and the patient's general health status (PGH) according to VAS. We assessed treatment adherence, need for nonsteroidal anti-inflammatory drugs (NSAIDs), satisfaction with treatment (based on VAS). The presence of comorbidities was also considered.Results and discussion. In hand OA (n=2776), a positive effect of therapy was observed in 98.6% of cases, according to patients' assessment. During the course of therapy, there was a significant decrease in pain on movement in the hands (according to VAS), improvement in PGH and quality of life (according to EQ-5D). Rapid development of the analgesic effect was seen on average at day 9.In hip OA (n=6666), a decrease in pain was noted in 83.3% of cases (<40 mm), improvement in PGH and quality of life in most patients, and a decrease in the need for NSAIDs in 64.9%.In the generalized form of OA (n=1694), significant clinical improvement was achieved in 97.1% of patients. A pain reduction ≥50% from baseline was noted in nearly 65% of cases.Elderly age, more severe radiographic manifestations of OA, low quality of life and compliance, and concomitant diseases were associated with a lower effect of therapy in hand and hip OA. In hand OA, high pain scores and worse PGH VAS scores also played a role. In hip OA, lower success was observed more often in women, and in hand OA — in men.In the generalized form of OA, lower satisfaction with pain management was associated with age, female sex, high body mass index, long history of OA, advanced radiographic stages, poorer quality of life and compliance, and comorbidity.Conclusion. The results of the use of Alflutop in hand and hip OA and generalized form of OA suggest the usefulness of its wide application in real clinical practice. Consideration and correction of the factors associated with less pronounced analgesic effect of the drug will improve the effectiveness of OA therapy.
Karst dan Dinamika Tektonik Formasi Wapulaka Kota Baubau
Authors: La Ode Malim Anna Irada , Amala RM Wa Ode 
Published: August 2023

Kota Baubau terletak di bagian barat daya Pulau Buton. Perkembangan dan pembangunan fisik serta ekonomi wilayahnya saat ini lebih terpusat pada bentangalam karst yang termasuk dalam Formasi Wapulaka karena lokasinya yang strategis. Namun, pembangunan di wilayah ini belum ditunjang dengan pemahaman yang memadai mengenai karakteristik karst itu sendiri. Pembentukan bentangalam karst dengan berbagai model morfologinya sangat dipengaruhi oleh aktifitas tektonik dan pelarutan. Pelarutan dapat membentuk rongga, meningkatkan porositas dan melemahkan batuan serta menyebabkan penurunan daya dukung lingkungan. Penelitian mengenai karakteristik karst diperlukan dalam pertimbangan penentuan arah pembangunan wilayah kota. Penelitian ini dilakukan dengan metode observasi lapangan dalam pengumpulan data morfologi permukaan dan bawah permukaan untuk menentukan tipe kelas karst, selanjutnya dikorelasikan dengan kelurusan topografi yang diidentifikasi dari peta SRTM, data sekunder berupa geologi regional dan hasil penelitian terdahulu, untuk membantu memahami peran tektonik dalam pembentukan morfologi karst tersebut. Perkembangan fitur karst permukaan dan bawah permukaan menunjukkan bahwa karst di wilayah ini termasuk kelas karst kompleks. Analisis kelurusan topografi menunjukkan dua periode deformasi yang berpengaruh pada orientasi morfologi karst. Korelasi data morfologi, kelurusan topografi, arah bukaan gua dan penelitian terdahulu mengindikasikan bahwa aktifitas tektonik sangat berpengaruh dalam pembentukan dan orientasi morfologi karst termasuk arah bukaan gua di bawah permukaan.
The Impact of the CARES Stimulus Payments on COVID-19 Transmission and Mortality
Authors: Atwood Alicia , Fleming Caitlyn 
Published: August 2023

Abstract
In this paper, we study the impact of the Coronavirus Aid, Relief, and Economic Security (CARES) Act economic impact payments to individuals on the spread of COVID-19 and subsequent mortality. There is a large economic literature linking income shocks and mortality. Using an event study approach and controlling for time-varying stay-at-home directives, we find no statistically significant change in confirmed case rates and no meaningful change to death rates from COVID-19. Our research suggests that distributing the individual stimulus payments at the same time to everyone had no effect on the spread of COVID-19.
Geological earthquake simulations generated by kinematic heterogeneous energy-based method: Self-arrested ruptures and asperity criterion
Authors: Venegas-Aravena Patricio 
Published: August 2023

Abstract
The lack of clarity regarding slip distribution within heterogeneous rupture areas has a significant impact on characterizing the seismic source and the role of heterogeneities in determining ground motion. One approach to understand the rupture process is through dynamic simulations, which require substantial computational resources, thereby limiting our comprehension of seismic rupture processes. Consequently, there is a need for methods that efficiently describe the spatial complexities of seismic rupture in a realistic manner. To address this, the statistics of real self-arrested ruptures that conform to the asperity criterion are investigated. This research demonstrates that power law distributions can describe the final slip statistics. Regarding the computational efficiency, a simple heterogeneous energy-based (HE-B) method is proposed. The HE-B method is characterized by the spatial correlation between the rupture parameters, such as the final slip or the rupture velocity, and the distribution of residual energy which determines the zones where the rupture could occur. In addition, the HE-B method defines the rupture area in those zones of the fault where the coupling function exceeds the energy required for rupture initiation. Therefore, the size of the earthquake is directly influenced by the distribution of coupling within faults. This method also leads to the successful reproduction of the statistical characteristics of final slip and generates slip rates that match the kinematic behavior of seismic sources. Notably, this kinematic rupture simulation produces seismic moment rates characterized by

f

−
1

{f}^{-1}

and

f

−
2

{f}^{-2}

spectra with a double corner frequency. Finally, it is observed that the maximum fracture energy value within the ruptured area is strongly correlated with both the magnitude and peak seismic moment rate. Thus, by employing this method, realistic rupture scenarios can be generated efficiently, enabling the study of spatial correlations among rupture parameters, ground motion simulations, and quantification of seismic hazard.
SnakeLines: integrated set of computational pipelines for sequencing reads
Authors: Budiš Jaroslav , Krampl Werner , Kucharík Marcel , Hekel Rastislav , Goga Adrián , Sitarčík Jozef , Lichvár Michal , Smol’ak Dávid , Böhmer Miroslav , Baláž Andrej , Ďuriš František , Gazdarica Juraj , Šoltys Katarína , Turňa Ján , Radvánszky Ján , Szemes Tomáš 
Published: August 2023

Abstract
With the rapid growth of massively parallel sequencing technologies, still more laboratories are utilising sequenced DNA fragments for genomic analyses. Interpretation of sequencing data is, however, strongly dependent on bioinformatics processing, which is often too demanding for clinicians and researchers without a computational background. Another problem represents the reproducibility of computational analyses across separated computational centres with inconsistent versions of installed libraries and bioinformatics tools. We propose an easily extensible set of computational pipelines, called SnakeLines, for processing sequencing reads; including mapping, assembly, variant calling, viral identification, transcriptomics, and metagenomics analysis. Individual steps of an analysis, along with methods and their parameters can be readily modified in a single configuration file. Provided pipelines are embedded in virtual environments that ensure isolation of required resources from the host operating system, rapid deployment, and reproducibility of analysis across different Unix-based platforms. SnakeLines is a powerful framework for the automation of bioinformatics analyses, with emphasis on a simple set-up, modifications, extensibility, and reproducibility. The framework is already routinely used in various research projects and their applications, especially in the Slovak national surveillance of SARS-CoV-2.