bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into ENSO Diversity from an Intermediate Coupled Model. Part I: Uniqueness and Sensitivity of the ENSO Mode
Authors: Geng Licheng , Jin Fei-Fei 
Published: August 2023

Abstract
The basic dynamics of the spatiotemporal diversity for El Niño–Southern Oscillation (ENSO) has been the subject of extensive research and, while several hypotheses have been proposed, remains elusive. One promising line of studies suggests that the observed eastern Pacific (EP) and central Pacific (CP) ENSO may originate from two coexisting leading ENSO modes. We show that the coexistence of unstable EP-like and CP-like modes in these studies arises from contaminated linear stability analysis due to unnoticed numerical scheme caveats. In this two-part study, we further investigate the dynamics of ENSO diversity within a Cane–Zebiak-type model. We first revisit the linear stability issue to demonstrate that only one ENSO-like linear leading mode exists under realistic climate conditions. This single leading ENSO mode can be linked to either a coupled recharge-oscillator (RO) mode favored by the thermocline feedback or a wave-oscillator (WO) mode favored by the zonal advective feedback at the weak air–sea coupling end. Strong competition between the RO and WO modes for their prominence in shaping this ENSO mode into a generalized RO mode makes it sensitive to moderate changes in these two key feedbacks. Modulations of climate conditions yield corresponding modulations in spatial pattern, amplitude, and period associated with this ENSO mode. However, the ENSO behavior undergoing this linear climate condition modulations alone does not seem consistent with the observed ENSO diversity, suggesting the inadequacy of linear dynamics in explaining ENSO diversity. A nonlinear mechanism for ENSO diversity will be proposed and discussed in Part II.
Trends in mental health inequalities for people with disability, Australia 2003 to 2020
Authors: Bishop Glenda M , Kavanagh Anne Marie , Disney George , Aitken Zoe 
Published: August 2023

Objective: Cross-sectional studies have demonstrated that people with disability have substantial inequalities in mental health compared to people without disability. However, it is not known if these inequalities have changed over time. This study compared the mental health of people with and without disability annually from 2003 to 2020 to investigate time trends in disability-related mental health inequalities. Methods: We use annual data (2003–2020) of the Household, Income and Labour Dynamics in Australia Survey. Mental health was measured using the five-item Mental Health Inventory. For each wave, we calculated population-weighted age-standardised estimates of mean Mental Health Inventory scores for people with and without disability and calculated the mean difference in Mental Health Inventory score to determine inequalities. Analyses were stratified by age, sex and disability group (sensory or speech, physical, intellectual or learning, psychological, brain injury or stroke, other). Results: From 2003 to 2020, people with disability had worse mental health than people without disability, with average Mental Health Inventory scores 9.8 to 12.1 points lower than for people without disability. For both people with and without disability, Mental Health Inventory scores decreased, indicating worsening mental health, reaching the lowest point for both groups in 2020. For some subpopulations, including young females and people with intellectual disability, brain injury or stroke, mental health inequalities worsened. Conclusion: This paper confirms that people with disability experience worse mental health than people without disability. We add to previous findings by demonstrating that disability-related inequalities in mental health have been sustained for a long period and are worsening in some subpopulations.
A Survey of Pharmacists and Other Healthcare Professionals in Vietnam: Factors Influencing Knowledge and Attitudes Toward Reporting Adverse Drug Reactions
Authors: Tran Van De , Tran Thi Ngoc Kieu , Vo Quang Loc Duyen , Pham Kieu Anh Tho , Dewey Rebecca Susan , Van Cong Khanh , Dorofeeva Valeria Valeryevna 
Published: August 2023

Background: Knowledge and attitudes of healthcare professionals are significant factors that affect the reporting of adverse drug reactions (ADRs). No previous research has examined the predictors of knowledge and attitudes toward ADR reporting in Vietnam. Objectives: The aim of this study was to examine the factors (ie, demographic and job-related characteristics) associated with inadequate knowledge and negative attitudes toward ADR reporting in a Vietnamese public hospital. Methods: A survey recruited a cross-sectional sample of 511 healthcare professionals (with a response rate of 92.9%) at a public hospital in Vinh Long province, Vietnam, from December 2022 to February 2023, using a self-administered questionnaire. Factors related to knowledge and attitudes toward ADR reporting were identified using univariate and multivariate logistic regression. Results: Pharmacists had significantly lower knowledge scores (mean = 5.86) than medical practitioners (7.24) and nurses (6.72). Additionally, pharmacists’ attitudes scored significantly lower (34.61) than those of medical practitioners (37.21) and nurses (36.86). Multivariate logistic regression showed that educational level, healthcare profession, monthly on-call shifts, and number of direct patient interactions were factors associated with a lower level of knowledge regarding ADR reporting. Additionally, age group and healthcare profession were identified as factors associated with negative attitudes toward ADR reporting among healthcare workers. Conclusions: Our study identified several factors associated with lower levels of knowledge and negative attitudes toward ADR reporting among healthcare workers in Vietnam. These findings highlight the need for targeted interventions and education programs to improve healthcare workers’ knowledge and attitudes toward ADR reporting.
Effectiveness and Safety of Percutaneous Treatment in Lesions Suggestive of Thyroid Cancer (Bethesda V and VI—T1aN0M0) Compared to Surgical Treatment: Systematic Review and Meta-Analysis
Authors: Hurtado Amézquita Yesid Camilo , Latorre Nuñez Yulieth , Flórez Romero Andrés , Mejía López María Gimena 
Published: August 2023

Introduction: Thyroid nodules are common entities, with 5% malignancy. Differentiated thyroid cancer represents 90% of thyroid malignancies, with papillary carcinoma being the most common. Management is generally surgical; among its complications are injury to the recurrent laryngeal and superior laryngeal nerve, causing hoarseness, postsurgical hypoparathyroidism, hypothyroidism, and pain. Other noninvasive percutaneous interventions of thermal ablation such as microwave, radiofrequency, or laser incur lower costs and could be an option for treatment. Objective: To determine the effectiveness and safety of thermal ablation in lesions suspected of thyroid cancer (Bethesda V and VI/T1aN0M0) compared to surgical treatment. Methods: Systematic review/meta-analysis of observational studies and clinical trials. Database search includes MEDLINE/PUBMED, Embase, Scopus, Scielo, and BVS/LILACS. Studies on patients over 18 years of age with lesions suspicious of thyroid cancer were included. Results: A total of 10 studies were obtained, with 2939 patients: 1468 subjected to thermal ablation and 1471 to surgery. Regarding effectiveness, no differences were found in local recurrence [relative risk (RR) 1.17 (95% CI 0.69-1.99)] and cervical lymph node metastasis [RR 0.76 (95% CI 0.43-1.36)]. Regarding safety, infection [RR 0.29 (95% CI 0.05-1.74)], hematoma [RR 0.57 (95% CI 0.17-1.94)], and transient hoarseness [RR 0.77 (95% CI 0.39-1.51)] were evaluated, without difference. However, permanent hoarseness had significant differences in favor of thermal ablation [RR 0.29 (95% CI 0.11-0.75)]. Conclusions: Thermal ablation for the treatment of T1aN0M0 papillary thyroid carcinoma is equally effective when compared to surgical techniques and offers a better safety profile, particularly in permanent hoarseness.
Does the kidney actually swell during an acute urinary tract obstruction?
Authors: Sahlén Klara , Lönnemark Olle , Lönnemark Maria , Wernroth Lisa , Magnusson Anders 
Published: August 2023

Background The appearance of renal swelling during an acute obstruction of the urinary tract could be caused by hydronephrosis or an increase of the parenchymal volume. To the best of our knowledge no studies have been performed regarding renal parenchymal volume change during an acute urinary tract obstruction. Purpose To investigate the change in renal parenchymal volume during an acute urinary tract obstruction and to correlate any such volume change to the degree of secondary signs of obstruction. Material and Methods In total, 20 patients with obstructive ureterolithiasis were retrospectively and randomly included. Two observers measured the parenchymal volume of the obstructed and the contralateral kidney in CT examinations before, during, and after obstruction. Hydronephrosis, hydroureter, perirenal stranding, and thickening of the renal fascia were graded and correlated to volume change. Results A decreased volume was noted after obstruction in the obstructed kidneys (−24%) ( P < 0.0001) and in the contralateral kidneys (−5%) ( P = 0.0110) with a positive correlation of change in volume ( P = 0.011). The volume of the obstructed kidneys was larger than the contralateral kidneys during obstruction ( P < 0.0001) but not after obstruction ( P = 0.559). No significant difference in volume was found before compared to after obstruction. Secondary signs of obstruction did not correlate to volume change. Conclusion The parenchymal volume increases in the obstructed kidneys as well as in the contralateral kidneys during obstruction. The increase in volume was larger in the obstructed kidneys compared to the contralateral kidneys. After obstruction the kidneys regained their original volume. Secondary signs did not correlate to volume change.
Prevention of complications of surgical treatment of stage III-IV cystocele using light polypropylene mesh
Authors: Banakhevych Roman , Akymova Klavdiia , Pariienko Kateryna , Nechaiev Vsevolod 
Published: August 2023

Objective: The purpose of study was to report the subjective and objective results of different methods of surgical treatment of cystocele using the transvaginal Mesh-system. Methodology: A prospective study was conducted from January 2017 to December 2020 comparing anterior colporrhaphy with vaginal mesh and two distinct types of vaginal wall repair sutures in the surgical treatment of cystocele. The primary endpoint was the incidence rate of vaginal wall erosion complications 12 months after surgery. Secondary endpoints were anatomic outcomes, TVM-related morbidity, and patient satisfaction measured using validated questionnaires. Results: In total, 102 patients with stage III-IV cystocele and the average age of 67.2 ± 3.1 years (age range of 47–79 years old) took part in the study. Of the 102 women initially enrolled, 102 (100%) were successfully followed up 12 months after primary surgery. The primary result, the objective erosion development, was radically different in the comparison groups (1.6% against 23.5%, respectively). Analysis of the improved method of operative treatment showed a prominent level of positive, uncomplicated, surgery results of 98.4% (60/61). The anatomic success rate of recovery from cystocele was 99.9% (101/102) 12 months after surgery. Conclusion: The suggested method of restoring the anterior vaginal wall in stage III-IV isolated cystocele without signs of incomplete and complete prolapse of the uterus showed a radically positive result. The number of complications was relatively high in the comparison group, but no difference was observed in satisfaction with the anatomical results of the surgery. The percentage of the vaginal wall erosion when using a single-layer suture is 23.5%, when using a two-layer suture is 1.6%
Acceptability and Feasibility of Text Message Interface to Assess Parents’ Real-time PICU Experiences
Authors: Rothschild Charles B. , Balistreri Kathryn A. , Mulligan Kathryn , Lee K. Jane , Karst Jeffrey , Privatt Miranda , Magner Kristin , Lee Han-Joo , Scanlon Matthew , Davies W. Hobart ,   for the Pediatric Collaborative for Resilience and Emotional Wellness Science (Pediatric CREWS)
Published: August 2023

Introduction Parents of children in the pediatric intensive care unit (PICU) experience substantial stress; a parent's perception of their child's illness severity, more than objective measures, predicts psychological outcomes. No tools exist to assess parents’ real-time experiences. This pilot study evaluated the feasibility and acceptability of a text-based tool to measure parental experience. Methods Inclusion criteria included PICU stay >48 h, physician approval, smartphone access, and English-speaking caregiver. Eligible parents received a text-based baseline survey and surveys every other day while hospitalized regarding their mood/experiences and optional open-ended questions regarding stressors. They received post-discharge follow-up surveys at 1 week and 1, 3, and 6 months. Follow-up surveys assessed mood and symptoms of depression, anxiety, and post-traumatic stress. Interviews and surveys about the interface were conducted 1 week and 3 months following discharge. Feasibility was assessed by descriptive statistics (eg, response rates), and acceptability was assessed by descriptive statistics (survey results) and thematic analyses of interviews. Results Of 20 enrolled participants, the first 5 were excluded due to technical issues. Of the 15 included, results demonstrated feasibility and acceptability. Most participants (86%) completed all surveys during the PICU stay and continued to complete surveys at a high rate: 79%–94% 3 months post-discharge. All participants agreed that the system was easy to use and were satisfied with the system at discharge, and 91% remained satisfied 3 months post-discharge. Additionally, 76% reported comfort, and 69% reported benefit. From the interviews, participants lauded the system's convenience and applicability of content. Some proposed changes to improve ergonomics. Many suggested this interface could help teams better support families. Conclusions A text-based interface for measuring experience in the PICU is feasible and acceptable to parents. Further research can explore how this could identify parents most at risk of adverse psychological sequelae and lead to earlier supportive interventions.
Chlamydia trachomatis infection in Cuban adolescent and young populations
Authors: Soto Brito Yudira , Fonseca Castro Darien Alejandro , Guilarte Garcia Elias , Kouri Cardellá Vivian , Ramirez Cardentey Celeste , Mondeja Rodriguez Brian Arturo , Concepción López Jesús José , Sánchez Alvarez María de Lourdes , López Pérez Maida , Gutierrez Coronado Teresita , Torres Mosqueda Karelia , Suárez Licor Georgina 
Published: August 2023

Background In Cuba, little is known regarding the prevalence of Chlamydia trachomatis (CT) infection in adolescents and young people. We study the frequency of CT infection in these populations, and its association with clinical-epidemiological variables. Methods A total of 496 individuals aged 12 to 24 were recruited from November 2018 to November 2019. Of them, 302 were patients attending at sexually transmitted infections (STI) services and 194 were young volunteers. CT detections were carried out by real-time PCR and IgG serology. Results The prevalence of CT using PCR was 9.1% (45/496); 12.3% (37/302) for subjects attending STI service and 4.1% (8/194) for young volunteers, being significantly higher in the first group (OR=3.25; p=.001). CT IgG antibodies was detected in 38.6% (81/210). Individuals from 12 to 17 years old were more likely infected with CT (OR=2.21; p=.010). Infection was associated with the early onset of sexual intercourse, the frequent changing of sexual partners and black ethnicity. Conclusions The results suggest that Cuban adolescents and young populations are at highest risk of acquiring CT infection and developing reproductive complications. The data obtained advise the needs of implementation of a routine CT screening strategy, for timely diagnosis, detection and treatment at the earliest ages.
Breakthroughs in Alzheimer’s Research: A Path to a More Promising Future?
Authors: Fatima Hareer , Rangwala Hussain Sohail , Riaz Faiza , Rangwala Burhanuddin Sohail , Siddiq Mohammad Arham 
Published: August 2023

Background Alzheimer’s disease (AD) is a widespread neurodegenerative disorder with a significant global impact, affecting approximately 50 million individuals, and projections estimate that up to 152 million people will be affected by 2050. AD is characterized by beta-amyloid plaques and tau tangles in the brain, leading to cognitive decline. Summary Recent research on AD has made significant strides, including the development of an “amyloid clock” biomarker that tracks AD progression through positron emission tomography (PET) scans. Surf4 and other genes have been discovered to play a role in regulating beta-amyloid toxicity, while inhibiting the enzyme hexokinase-2 has shown positive results in preclinical studies. New brain mapping techniques have identified early brain-based causes of cognitive changes in AD, and biomarkers such as neuronal pentraxin protein Nptx2 and astrocytic 7-subunit of the nicotinic acetylcholine receptors (7nAChRs) show potential for early detection. Other approaches, such as replenishing the enzyme Tip60, selectively degrading the modified protein p-p38 with PRZ-18002, and targeting the protein voltage-dependent anion channel-1 (VDAC1), have shown promise in enhancing cognitive function and preventing pathophysiological alterations linked to AD. Baseline blood samples and other biomarkers such as urine formic acid, p-tau 198, microRNAs, and glial fibrillary acidic protein (GFAP) have also been discovered for early detection and intervention of AD. Additionally, recent FDA approvals for medications such as aducanumab and lecanemab provide options for reducing AD symptoms and improving function, while clinical trials for dementia vaccines show promise for the nasal and beta-amyloid 40 vaccines as well as vaccinations targeting tau. Key Messages These advancements in AD research, including biomarker discovery and the development of disease-modifying treatments, are crucial steps towards improving the lives of those affected by AD and finding a cure for this debilitating disease.
Analyzing Linguistic Disparities in Telehealth Care Outcomes at a Multidisciplinary Craniofacial Center
Authors: Danial Elizabeth , Rios Jennifer , Badiee Ryan , Rosenbluth Glenn , Pomerantz Jason H. 
Published: August 2023

Objective To examine linguistic disparities between English- and Spanish-speaking patients in access to care, satisfaction, and telehealth appointment attendance. Design Retrospective study recording demographics for non-attendance analysis and conducting phone surveys assessing satisfaction with telehealth. Setting Data was collected between March and December 2020 at the UCSF Craniofacial Center (CFC), a multidisciplinary pediatric clinic. Patients: English- and Spanish-speaking patients with a telehealth appointment. Interventions: The CFC offered language-concordant outreach, assistance with the telehealth platform, and interpreters at all telehealth appointments. Main Outcome Measures Demographics and patient-reported satisfaction with telehealth, barriers, and instruction clarity. Results Medicaid insurance was the only predictor of non-attendance. Surveys revealed that Spanish-speakers had 12.4 times the odds of lacking access to telehealth technology and 10.7 times the odds of needing help with logging on compared to English-speakers. There were no significant differences in satisfaction outcomes. Conclusions We attribute this equity in satisfaction to our language-concordant outreach efforts.
A Comparison of Injectable Diazepam and Lorazepam in the Goal-Directed Management of Severe Alcohol Withdrawal
Authors: Brickel Kendall H. , Hodge Emily K. , Zavgorodnyaya Daria , Schroeder John M. , Brown Lawrence H. , Daley Mitchell J. 
Published: August 2023

Background: Benzodiazepines are the gold standard for treatment of alcohol withdrawal, yet the selection of a preferred benzodiazepine is limited due to a lack of comparative studies. Objectives: The primary objective of this study was to compare the efficacy and safety of injectable lorazepam (LZP) and diazepam (DZP) in the treatment of severe alcohol withdrawal syndrome (AWS). Methods: Retrospective cohort study of adult patients admitted to an intensive care unit with a primary diagnosis of AWS. Subjects who received at least 12 LZP equivalent units (LEU) of injectable DZP or LZP within 24 hours of initiation of the severe AWS protocol were included. The primary outcome was time with Clinical Institute Withdrawal Assessment for Alcohol–Revised (CIWA-Ar) scores at goal over the first 24 hours of treatment. Results: A total of 191 patients were included (DZP n = 89, LZP n = 102). Time with CIWA-Ar scores at goal during the first 24 hours was similar between groups (DZP 12 hours [interquartile range, IQR, = 9-15] vs LZP 14 hours [IQR = 10-17]), P = 0.06). At 24 hours, LEU requirement was similar (DZP 40 [IQR = 22-78] vs LZP 32 [IQR = 18-56], P = 0.05). Drug cost at 24 hours was higher in the DZP group ($204.6 [IQR = 112.53-398.97] vs $8 [IQR = 4.5-14], P < 0.01). Conclusion and Relevance: DZP or LZP are equally efficacious for the treatment of severe AWS. LZP may be preferred due to cost but both medications can be used interchangeably based on availability.
The characteristic impedance calculation method of microstrip line and application in embroidered microstrip line
Authors: Zhang Yaya , Jin Haiming , Tu Huating , Zuo Yuxin , Luo Qiulan , Li Ping , Chen Zihan , Jia Jingjing , Zhang Linmei 
Published: August 2023

Presently, it is difficult to measure the characteristic impedance of embroidered microstrip line for its conductive anisotropy directly. The published work had proposed to use S-parameters to estimate the port impedance of a balanced dipole antenna, and it cannot be used to calculate the characteristic impedance of microstrip lines with one arm. Thus, it is still a problem on measuring and obtaining 50 Ω characteristic impedance of embroidered microstrip line. Therefore, taking the reflection coefficient as an intermediate variable, this work proposes to use return loss [Formula: see text] to derive the expression of the characteristic impedance of microstrip line. Combined theoretical calculation with experimental testing on characteristic impedance of the fabric-based microstrip line, the expression of the characteristic impedance was verified. Then, the expression of the characteristic impedance of microstrip line was used to calculate the characteristic impedance of embroidered microstrip line and determine its equivalent substrates. The results show that the fabric embroidered with a single-layer conductive strip is a part of its equivalent substrate, and the fabric embroidered with a double-layer conductive strip is not a part of its equivalent substrate.