bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurointerventional infusion of hemoglobin oxygen carrier prevents brain damage from acute cerebral ischemia in rats
Authors: Gao Hong , Peng Han , Yang Hua , Li Qiuping , Xiang Xin 
Published: March 2023

AimTo save brain cells in acute cerebral infarction by injecting hemoglobin oxygen carrier (HBOC) into the blood vessel blockage of the cerebral infarction site through a microcatheter.Methods120 male rats were divided into four groups: control (CTRL), ischemia (I), ischemia + low perfusion (I + LP), and ischemia + high perfusion (I + HP). Perfusion groups (ischemia, I + LP, and I + HP) underwent MCAO surgery with intraluminal monofilament. These groups were subdivided into 6 h, 12 h, and 24 h (n = 10/group). RT-PCR, Western-Blot, immunohistochemistry, and apoptosis assays were used to detect apoptosis, hypoxia range and extent, and ischemia.ResultsCompared with the I group, the neurological deficit sign scores of the I + HP group were statistically significant at 12 h. Compared with the I group, the neurological deficit sign scores of the I + LP group and the I + HP group were statistically significant at 24 h. At all time points, compared with the I group and the I + LP group, Caspase-3, HIF-1α, and Cytochrome C protein levels were significantly decreased in the I + HP group. Bcl-2 and BAX mRNA levels were also significantly decreased in the same group. TNF-α, IL-6, and IL-1β cytokines were significantly decreased in the I + HP group as well. The infarct size of rats in the I + HP group was smaller than that of the I + LP group, which was smaller than ischemia alone. Time of perfusion had an obvious effect as infarct size was smaller with longer perfusion. The number of Nissl stained cells in the I + HP group was increased compared with the ischemia and the I + LP group, and was proportional to the time of perfusion.ConclusionTime- and rate-controlled perfusion of HBOC to acutely occluded cerebral vascular regions through microcatheters can effectively protect ischemic brain tissue in rats.
Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint
Authors: Zamith Cunha Rodrigo , Zannoni Augusta , Salamanca Giulia , De Silva Margherita , Rinnovati Riccardo , Gramenzi Alessandro , Forni Monica , Chiocchetti Roberto 
Published: March 2023

BackgroundThe metacarpophalangeal joint undergoes enormous loading during locomotion and can therefore often become inflamed, potentially resulting in osteoarthritis (OA). There are studies indicating that the endocannabinoid system (ECS) modulates synovium homeostasis, and could be a promising target for OA therapy. Some cannabinoid receptors, which modulate proliferative and secretory responses in joint inflammation, have been functionally identified in human and animal synovial cells.ObjectiveTo characterize the cellular distribution of the cannabinoid receptors 1 (CB1R) and 2 (CB2R), and the cannabinoid-related receptors transient receptor potential vanilloid type 1 (TRPV1), G protein-related receptor 55 (GPR55) and peroxisome proliferator-activated receptor alpha (PPARα) in the synovial membrane of the metacarpophalangeal joint of the horse.AnimalsThe dorsal synovial membranes of 14 equine metacarpophalangeal joints were collected post-mortem from an abattoir.Materials and methodsThe dorsal synovial membranes of 14 equine metacarpophalangeal joints were collected post-mortem from an abattoir. The expression of the CB1R, CB2R, TRPV1, GPR55, and PPARα in synovial tissues was studied using qualitative and quantitative immunofluorescence, and quantitative real-time reverse transcriptase PCR (qRT-PCR). Macrophage-like (MLS) and fibroblast-like (FLS) synoviocytes were identified by means of antibodies directed against IBA1 and vimentin, respectively.ResultsBoth the mRNA and protein expression of the CB2R, TRPV1, GPR55, and PPARα were found in the synoviocytes and blood vessels of the metacarpophalangeal joints. The synoviocytes expressed the mRNA and protein of the CB1R in some of the horses investigated, but not in all.Conclusions and clinical importanceGiven the expression of the CB1R, CB2R, TRPV1, GPR55, and PPARα in the synovial elements of the metacarpophalangeal joint, these findings encouraged the development of new studies supporting the use of molecules acting on these receptors to reduce the inflammation during joint inflammation in the horse.
COVID-19 and Breast Cancer in Brazil
Authors: Rocha Aline Ferreira Bandeira Melo , Freitas-Junior Ruffo , Ferreira Glalber Luiz Rocha , Rodrigues Danielle Cristina Netto , Rahal Rosemar Macedo Sousa 
Published: March 2023

Objectives: This study aimed to evaluate COVID-19 effects on breast cancer screening and clinical stage at diagnosis in patients of 50–69 years of age receiving care within the public healthcare network (SUS) in 2013–2021 in Brazil and its macro-regions.Methods: This ecological study used Poisson regression to analyze trends in screening and staging. A secondary database was formed using SUS sources: outpatient data system of the SUS network and Oncology—Brazil Panel.Results: There was a reduction in screening, with an annual percent change of −5.9 (p &lt; 0.022). The number of notified cases fell by 31.5% in 2020–2021 compared to 2018–2019. There was a 10.7% increase in the proportion of stage III/IV cases (p &lt; 0.001) in 2020–2021 compared to 2013–2019, now surpassing the number of cases of early stage breast cancer.Conclusion: COVID-19 led to a reduction in breast cancer screening and an expressive increase in advanced tumors in users of the public healthcare network. Urgent interventions in public policies are required as the negative effects of the pandemic on the diagnosis/treatment of breast cancer are becoming apparent even earlier than expected.
Simulação realística em enfermagem: a experiência discente enquanto vítima de trauma em desafio
Authors: França Júlio Ricardo , Costa Letícia Dantas , Rodrigues Filho Luiz Fernando , Pereira Nicolle Garcia Beltran Gonçalves , Soares Nicole da Silva 
Published: March 2023

Introdução: Compreende-se como APH um serviço prestado que abrange intervenções perante cenas que causam risco iminente à vida, esta assistência prévia pode minimizar as taxas de morbimortalidade antecedente à chegada em uma unidade hospitalar. Objetivos: Descrever as experiências vivenciadas por acadêmicos sob a perspectiva de atuarem como vítimas no 1° Desafio Sul-Mato Grossense de Salvamento Veicular e Trauma. Metodologia: Relato de experiência descritivo, realizado a partir da vivência de estudantes de uma liga acadêmica de enfermagem, que participaram como vítimas realísticas, no 1º Desafio Sul-Mato-Grossense de Salvamento Veicular e Trauma. Resultados: Os manequins vivos obtiveram maior aprendizado, pois, participaram da simulação de forma direta, sem ter o sentimento de nervosismo ou estar disperso com a vibração da torcida, e o mais importante observaram de outro ângulo, no qual remete a visão de uma vítima real e sentir vivência de receber um atendimento de diferentes profissionais em diferentes situações. Discussão: Para que seja realizado um atendimento de qualidade, as formações acadêmicas devem estar de acordo com o que exige do profissional em campo, pode-se visualizar a necessidade de relacionar a teoria com a prática, bem como o preparo físico e psicológico, agilidade e perfil para atuar no APH. Considerações finais: vivenciar o atendimento inicial à vítima de trauma, promove em alunos a oportunidade de acompanhar e solucionar o que era proposto de acordo com o caso evidenciado, bem como desenvolver visão crítica para a resolução dos problemas.
hijos del obraje a productores algodoneros.
Authors: Bonetti Carlos , Suárez Mauricio , Franzzini Mónica 
Published: March 2023

El artículo pone el foco en el surgimiento de la acción colectiva del campesinado santiagueño durante la década del ochenta, específicamente en la localidad de Los Juríes. Por una parte, se describe el proceso organizativo y sus vínculos con actores eclesiales, técnicos, gremiales y estatales en un derrotero de politización del sector que se materializó en la conformación de la Comisión Central de Campesinos. Por otro, se busca problematizar la producción de discursos sobre la identidad campesina evidenciado las representaciones que diversos actores –de manera positiva o negativa- comienzan a cimentar discursivamente en la construcción de un sujeto colectivo que posteriormente decantará en la formación del MOCASE (Movimiento Campesino de Santiago del Estero) y de otras organizaciones y comunidades indígenas en los últimos años. A partir del análisis de un corpus documental compuesto por recortes periodísticos, informes técnicos, actas de reuniones, conjuntamente con entrevistas a informantes claves, contribuimos a problematizar las formas de construcción de la identidad política campesina en momentos embrionarios de lucha y resistencia tras los conflictos territoriales.
A família Orchidaceae em um fragmento de floresta estacional semidecidual, no município de Barroso, Minas Gerais, Brasil
Authors: Menini Neto Luiz , Assis Leandro C. de S. , Forzza Rafaela C. 
Published: March 2023

The present study is an account of the species of Orchidaceae occurring in the Mata do Baú, localized in the municipality of Barroso, in the Campo das Vertentes in Minas Gerais. The predominant vegetational formation in the area studied is a seazonal semidecidous forest, which is associated to areas of riverine forest and of campo-cerrado. The family Orchidaceae is represented in the area by 25 genera and 44 species. The genera with higher diversity are Epidendrum and Oncidium (5 spp.), Campylocentrum (4 spp.), and Encyclia, Habenaria and Pleurothallis (with three species each one). Keys, descriptions, illustrations, geographical distribuition and taxonomic comments to each species are provided.
Key words: Orchidaceae, Cerrado, “Campo das Vertentes”, Taxonomy, Minas Gerais, Seazonal Semidecidous Forest.
Efemeropterofauna (Insecta: Ephemeroptera) do trecho ritral inferior do Rio Campo Belo, Itatiaia, RJ: composição e mesodistribuição
Authors: Francischetti Cesar N. , Silva Elidiomar R. da , Salles Frederico F. , Nessimian Jorge L. 
Published: March 2023

Samples from the Campo Belo river located in the municipality of Itatiaia, RJ (22o28’S; 44o34’W), in different mesohabitats, registered the occurrence of 22 species, distributed in the following genera (number of species between brackets): Americabaetis (2), Aturbina (1), Baetodes (1), Callibaetis (1), Camelobaetidius (2), Cloeodes (1), Paracloeodes (2) (Baetidae); Leptohyphes (2), Leptohyphodes (1), Tricorythopsis (3), Tricorythodes (1) (Leptohyphidae), Farrodes (1), Massartella (1), Miroculis (1), Thraulodes (1); and Ulmeritoides (1) (Leptophlebiidae). From monthly quantitative collections, taken from October 1999 to September 2000, 3.175 specimens were obtained, 1.002 from the riparian vegetation, 785 from pool litter, 665 from the rocky substratum, 436 from the riffle litter and 287 from gravel/sand. The months with the highest number of individuals were November (595 individuals) and October 1999 (480 individuals). Species number collected in the studied site should be considered in a high degree in compare with other studies carried out in 3rd and 4th orders rivers in Brazil. This fact was probably produced due a most precise identification of the taxa, as a consequence of the recent improves of the taxonomic studies about Ephemeroptera in Brazil and South America.
Key words: Ephemeroptera, mesodistribution, southeastern Brazil.
Studies on Neotropical Protoneuridae. 16. The female of Neoneura gaida Racenis, 1953 (Odonata: Protoneuridae)
Authors: Machado Ângelo B. M. 
Published: March 2023

The female of Neoneura gaida Racenis, 1953 is described and illustrated. It is very close to that of N. cristina Racenis, 1955 but can be separated from it by the shape of the posterior pterothoracic lobe.
Keywords: Odonata, Protoneuridae, Neoneura.
Variação geográfica de Roeboexodon geryi (Myers) (Ostariophysi: Characiformes: Characidae)
Authors: Lucena Carlos A. S. de , Lucinda Paulo H. F. 
Published: March 2023

Populations of Roeboexodon geryi from Suriname, French Guiana, rio Xingu, rio Tapajós, and rio Tocantins in the Amazon region obtained from zoological collections were studied in order to verify the existence of undescribed species in the genus. However, although the results showed trends on differentiation between Surinam/French Guiana vs. Amazon basin relative to number of scales on lateral line, these were not diagnostic. The results of a Free-Size Canonical Variate Analysis also revealed trends on formation of distinct morphological groups, but did not revealed diagnosable populations which could be putative species. These local differences are therefore interpreted as geographical variations of a single species of the monotypic genus Roeboexodon.
Keywords: fishes, distribution, taxonomy, neotropical region
Peningkatan Keaktifan dan Hasil Belajar Matematika Materi Uang Kertas menggunakan Model Role Playing Siswa Kelas II SD Negeri 3 Dermaji Tahun Pelajaran 2020/2021
Authors: Permana Gita Prihastiwi 
Published: March 2023

Peningkatan Keaktifan dan Hasil Belajar Matemtika Materi Uang Kertas Menggunakan Role Playing Siswa Kelas II SD Negeri 3 Dermaji Tahun Pelajaran 2020/2021”. Penelitian tindakan kelas ini didasari dari rendahnya keaktifan dan hasil belajar siswa pada muatan pelajaran Matematika materi “Uang Kertas” Kelas II SD Negeri 3 Dermaji. Tujuan perbaikan pembelajaran adalah untuk meningkatkan keaktifan dan hasil siswa kelas Kelas II SD Negeri 3 Dermaji muatan pelajaran Matematika materi “Uang Kertas”. Peneliti melaksanakan penelitian ini untuk memperbaiki proses pembelajaran, peneliti mengadakan perbaikan pembelajaran dengan menggunakan model Role Playing dengan menerapkan prinsip dan langkah PTK yaitu yaitu merencanakan (Planning), melakukan tindakan (Acting), mengamati (Observing) dan refleksi (Reflecting) dan dilakukan secara berdaur. Peneliti melaksanakan penelitian ini dalam 2 siklus perbaikan pembelajaran. Hasil yang diperoleh dari perbaikan pembelajaran ini adalah penggunaan model pembelajaran model Role playing dapat meningkatkan keaktifan belajar siswa di Kelas II SD Negeri 3 Dermaji. Pada siklus I siswa aktif sebesar 72.2%, siklus II sebesar 88.9%. Penggunaan model pembelajaran model Role Playing dapat meningkatkan hasil belajar siswa di Kelas II SD Negeri 3 Dermaji. Pada pra siklus sebesar 33.7%, siklus I sebesar 66.7%, dan siklus II sebesar 100%, sehingga peningkatan hasil belajar dari pra siklus ke siklus II sebesar 66.3%.
Peningkatan Keaktifan dan Hasil Belajar Peserta Didik Melalui Penerapan Model Pembelajaran Kooperatif Picture And Picture pada Tema Hidup Bersih dan Sehat Kelas II SD Negeri Kemitir 01
Authors: Indriani Titik 
Published: March 2023

Penelitian tindakan kelas ini bertujuan untuk meningkatkan hasil belajar peserta didik kelas II SD Negeri Kemitir 01 Kecamatan Sumowono Kabupaten Semarang. Berdasarkan observasi awal peneliti, pembelajaran yang dilaksanakan oleh guru dilakukan dengan ceramah, penugasan, tanya jawab, dan diskusi klasikal. Proses pembelajaran tersebut memberikan hasil belajar yang rendah. Oleh karena itu, peneliti menerapkan model pembelajaran Kooperatif Picture and Picture. Subjek penelitian tindakan adalah peserta didik kelas II SD Negeri Kemitir 01 Kecamatan Sumowono Kabupaten Semarang semester 1 tahun pelajaran 2020 / 2021. Subyek penelitian berjumlah 11 peserta didik meliputi 7 peserta didik laki-laki dan 4 peserta didik perempuan. Pelaksanaan penelitian dilakukan pada tanggal 17 November 2020 dan 23 November 2020. Instrumen penelitian berupa lembar observasi kegiatan guru, lembar kerja peserta didik, lembar penilaian tes formatif siklus 1 dan siklus 2. Hasil penelitian yang diperoleh dari penerapan model pembelajaran Kooperatif Picture and Picture adalah adanya peningkatan hasil belajar peserta didik kelas II SD Negeri Kemitir 01 Kecamatan Sumowono Kabupaten Semarang. Hasil tindakan siklus I adalah 36% peserta didik sudah mendapatkan hasi melampaui Kriteria Ketuntasan Minimal ( KKM ) yaitu 70 yang sebelumnya hanya 18% peserta didik yang dapat melampaui KKM. Sedangkan pada siklus II 82% dari peserta didik sudah dapat melampaui KKM. Simpulan dalam penelitian tindakan ini adalah penerapan model pembelajaran Kooperatif Picture and Picture dapat meningkatkan keaktifan dan hasil belajar peserta didik. Cara belajar dan pemahaman materi berpengaruh pada keaktifan dan hasil belajar. Saran dalam penelitian tindakan ini adalah: 1.) Dalam kegiatan belajar mengajar guru perlu memperhatikan kebutuhan peserta didik, kondisi fisik peserta didik dan psikis peserta didik agar tujuan pembelajaran dapat tercapai. 2.) Gunakan metode dan model pembelajaran yang bervariasi. 3.) Suasana pembelajaran yang menyenangkan sangat membantu peserta didik untuk dapat menyerap materi pelajaran dengan baik. 4.)Rencana pembelajaran hendaknya dipersiapkan dengan teliti termasuk evaluasi sehingga tujuan pembelajaran yang telah ditetapkan dapat tercapai. 5.) Berikan kesempatan peserta didik untuk mengekspresikan kemampuannya dalam papan pajangan.
Práticas didáticas e conhecimentos estatísticos de professoras da Educação de Jovens e Adultos
Authors: Santos Andrade Amanda Regina dos , Guimarães Gilda Lisbôa 
Published: March 2023

Objetivamos nesse estudo investigar as práticas didáticas e conhecimentos estatísticos de professoras da Educação de Jovens e Adultos sobre o ensino de pesquisa estatística. Para isso, procedemos uma entrevista semiestruturada tendo como instrumento um questionário que versou sobre o perfil dos professores e alunos da EJA, o ensino de estatística, a pesquisa e suas fases, e situações referentes à algumas fases do ciclo investigativo a serem solucionadas. Os resultados do estudo evidenciaram que os professorasapresentam limitações conceituais e metodológicas referentes aos conceitos estatísticos. Nesse sentido, demonstraramdificuldades em dominar e explorar conceitos ligados a estatística e a pesquisa, apresentando em muitas situações divergênciasentre o currículo previsto e as práticas docentes. Além disso, apresentaram dificuldades em construir gráficos e analisarprotocolos de estudantes da EJA, desconhecendo elementos estruturantes básicos, sendo a escala seu maior obstáculo. Concluímos que esses resultados refletem a necessidade de ampliar discussões em relação as concepções de ensino de conteúdos estatísticos das docentes que atuam na EJA, contribuindo para superação de lacunas que persistem.
Russia's new nuclear doctrine. Russian policy of deterrence.
Authors: slawomir.kleszcz@wat.edu.pl Sławomir 
Published: March 2023

ObjectivesThe main purpose of the article is to address the issues arising from the new nuclear doctrine of Russia. An attempt to analyze the document is "Russia's Nuclear Doctrine" as a new tool for the Russian Federation's nuclear deterrent policy. The performance changes over the years in Russia's approach to the use of nuclear weapons in the new doctrine in the times of the Soviet Union in global terms, as well as in the micro-region of Central Europe, especially during the war in Ukraine.MethodsThe article is theoretical and descriptive. The main research methods and techniques included in the work are: analysis and synthesis of literature; comparative method; inductive and deductive method.ResultsAn attempt was made to analyze the document "Russia's Nuclear Doctrine" as a new tool for the Russian Federation's nuclear deterrent policy. A presentation of how Russia's approach to the use of nuclear weapons has changed over the years.ConclusionsThe Russian approach to nuclear deterrent policy is changing and is often used as flexibly as Russia's policy towards the West is forged in a given situation - to build its own political interests. All this is very efficiently and sophisticatedly applied in society by means of propaganda and media controlled by the authorities, with which the rulers manipulate public opinion. According to the decree, the threshold for Russia's use of nuclear weapons remains unchanged and is relatively high. The essence of the Russian doctrine is the uncertainty of a potential adversary as to when it will be used.
Análisis de la producción y comercialización de banano en la provincia de El Oro en el periodo 2018-2022
Authors: León Ajila Josué Paúl , Espinosa Aguilar Marco Antonio , Carvajal Romero Héctor Ramiro , Quezada Campoverde Jesica 
Published: March 2023

El banano ocupa la posición número cuatro como alimento más importante en el planeta, donde Ecuador destaca como el principal exportador en el mundo cubriendo en un 29% el mercado internacional. La presente se plantea como objetivo analizar la producción y comercialización de banano en la provincia de El Oro en el periodo 2018-2022 y su contribución a la economía nacional. El tipo de investigación es de enfoque descriptivo, lo que permitió recopilar información relevante acerca de los datos históricos de la evolución de las exportaciones de banano. Las exportaciones de banano son el eje fundamental de la económica ecuatoriana en términos de valor bruto de producción después del cacao, el camarón y el café. En los últimos 5 años las exportaciones de banano decrecieron producto de la pandemia Covid-19, así como por los conflictos de la geopolítica internacional, aunque la economía se estableció con un crecimiento constante para el año 2021, se exportaron 6411,92 t obteniendo ingreso FOB de $ 3.181.532, mientras que para el año 2022 las exportaciones fueron de 6025,10 t logrando ingresos de $ 3.124.220 FOB, lo que significó un decreciente del -1,8% tanto en las exportaciones como en los ingresos de divisas generados. Cabe destacar que la producción y comercialización de banano, contribuye de forma significativa a la economía del país, proporcionando ingresos y empleo a las familias rurales que se dedican a esta actividad de subsistencia.
Fistula Arteriovenosa Congénita de Brazo Derecho en paciente masculino de 3 años con resolución quirúrgica. Informe de Caso
Authors: Alvarez Saltos Miguel David , Pérez Landázuri Tatiana Del Rosario , Vallejo Paccha Tatiana Lizbeth , Ríos Moreira Janina Margarita , Ocampo Bastidas Anabelle del Carmen 
Published: March 2023

Introducción: Se entiende como fístula arteriovenosa a una comunicación anormal que se produce entre las arterias y las venas. Las fístulas arteriovenosas pueden ser congénitas o adquiridas durante la vida. Sin embargo, en la presente investigación se analiza la fístula arteriovenosa desarrollada como congénita con antecedentes desde hace 2 años de masa pulsátil a nivel anterior de pliegue de codo del brazo derecho.
Objetivo general: Presentación de un caso clínico de Paciente masculino de 3 años que presenta cuadro de 2 años de evolución caracterizado por cianosis peribucal al esfuerzo físico que se acompaña de masa pulsátil a nivel anterior de pliegue del codo derecho compatible con fistula arteriovenosa congénita.
Conclusiones: Paciente masculino de 3 años sin antecedentes de importancia que acude a la emergencia por presentar cuadro de 2 años de evolución caracterizado por cianosis peribucal al esfuerzo físico que se acompaña de masa pulsátil a nivel anterior de pliegue del codo derecho donde se diagnostica fistula arteriovenosa congénita la cual requiere de resolución quirúrgica