bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Dry Fasting Effect during Ramadan on Protein Glycation in Saudi Individuals
Authors: AL-Amri Abdulaziz S. , Abo-Elmagd Yousry E. , Kadi Mai S. , Aloufi Faisal F. , Bakheit Khalid H. 
Published: March 2023

Introduction: The non-enzymatic protein glycation alters protein function and contributes to many biochemical disorders. The accumulation of advanced glycation end-products (AGEs) is associated with the complications of diabetes, kidney disease, metabolic disorders and degenerative diseases.
Objectives: This study was designed to measure the level of some glycated proteins such as glycated insulin and glycated hemoglobin in Saudi volunteers before and after dry fasting in Ramadan.
Methods: Blood samples were collected twice; first sample (before) and second sample (after) dry fasting. The study included 45 Saudi male volunteers, whose ages ranged between23 and 52 years They were divided into four groups: healthy, type II diabetic patients, smokers, and obese individuals. Plasma glucose level and HbA1c were measured immediately using (Beckman coulter). Assessment of insulin resistance was determined using the equation of homeostasis model for insulin resistance (HOMA-IR). Plasma insulin level and glycated insulin % were assayed by TSQ Vantage Triple Stage Quadruple LC/MS Mass Spectrometer from Thermo Scientific.
Results: Level of HbA1c, HOMA IR and glycated insulin in healthy, type II diabetic patients, smokers, and obese individuals showed significant decrease in the second sample. The level of HbA1c showed a significant decrease (p-value <0.0001) after dry fasting (5.69 ± 1.55 %), (6.14 ± 1.77%). The level of HOMA IR showed significant decrease (p-value <0.0001) after dry fasting (1.97 ± 1), (2.46 ± 1.28). The level of glycated insulin showed significant decrease (p-value <0.0001) after dry fasting (6.25 ± 2%), (7.71 ± 2.48%).
Conclusion: Glucose, HbA1c, HOMA IR, and glycated insulin levels showed a significant decrease after dry fasting. Reduced protein glycation and formation of advanced glycation end products, can improve the clinical course of many medical disorders. More researches are needed to understand the molecular mechanisms behind glycation-induced clinical disorders and diseases, as well as to correlate these mechanisms to the diagnosis and prevention of lifestyle-related diseases.
Does Psychoactive Substance Use Affect Academic Performance of Medical Students? A Systematic Review
Authors: Nkporbu A. K. , Stanley P. C. 
Published: March 2023

Background: The use of illicit drugs, alcohol, and tobacco is very common among medical students. Problems related to substance usage are currently of concern on a global scale. Despite this, the condition is frequently misdiagnosed because students attempt to conceal their issues and do not seek professional assistance.
Aim: To investigate how drug usage affects medical students' academic performance.
Design: A systematic review.
Data Sources: Systematic search for worldwide published literature from PsycINFO, Cochrane, Google Scholar, Science Direct, PubMed, and WHOLIS.
Study Eligibility Criteria: Studies that were part of this review provided information on the methodology, methods, and/or measurements for how drug usage affected medical students' academic performance.
Data Extraction: The researcher further gathered the information from the chosen publications and recorded the following information in a consistent table: (i) publication information (first author's last name, year, and location of study); (ii) the sample size of the report; (iii) the impact of substance abuse on medical students' educational outcomes; (iv) the tool used to measure academic performance; (v) the average age of the sample size; and (vi) the percentage of female and unmarried medical students.
Results: Only 8 studies out of a total of 2,007 papers met all the inclusion criteria. Selection procedure was based on the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA).
Conclusion: Medical students and people who use psychoactive substances become unproductive in their lives. Due to the dearth of longitudinal investigations, understanding the true origins of this situation is challenging. To ensure that students attain the goals of their medical education and contribute to society's demand for more qualified and better trained medical professionals, medical training institutes may need to enact stricter prohibitions on drug use among students. The availability of medicines should be restricted in order to deter medical students from using and misusing them.
Hospital Location Allocation in Murshidabad District by GIS-Based MCA and Analytical Hierarchy Process
Authors: Mandal Sakti 
Published: March 2023

Hospitals are one of the most important infrastructural objects. The increasing population, especially in developing countries, amplifies the demand for new hospitals. Identifying the best locations for new hospitals is an important issue due to the fact that selecting suitable locations will help the government to optimize the allocation of medical resources, simplify social contradictions and control the health care development in rural and urban areas.
The district Murshidabad is situated in the bank of Padma and Bhagirathi River. Only 135 primary health centers are there, which provide very basic health services and they are randomly located in the district. No emergency health supporting facilities are present in those health centers and some of them are not opened for 24 hours in a day. Even the block primary health center is also very poor to take admissions of serious patients. Most of the times these health centers ask patient-parties to shift the patient Murshidabad medical college hospital. This is a very tuff job for emergency patients. Sometimes, patient-parties fail to shift the patient to a good hospital for very limited ambulance facility.
To solve the problem, it is very necessary to establish new hospitals or improve the services provided by the existing health centers. And as hospitals are one of the most important health services needed for the whole society, so they must be located in a rational manner so that we can maximize the accessibility of healthcare.
In this paper, we built site suitability analysis for selecting the optimal site for building new hospitals based on using MCA, AHP and Pair wise comparison method.GIS tool and techniques are employed to analyze the list of identified criteria in hospital site selection. These criterion are Population density, Distance from existing health centers, Proximity to road, Distance from railway track, Distance from river, Distance from industrial zones, Proximity to settlement, Proximity to educational institutions, Proximity to rail stations.
The results shows that though suitable areas are scattered over the entire region but most of the suitable areas are situated in the northern part of Murshidabad as national highway andrailway enhance the accessibility of the region. And also the result shows that the southernpart some area is very unsuitable for building new hospital. And it is also true that someexisting hospitals were not built in the suitable place.
In‐vivo quality assurance of dynamic tumor tracking (DTT) for liver SABR using EPID images
Authors: Rostamzadeh Maryam , Luchka Kurt , Ma Roy , Liu Mitchell , Dunne Emma , Camborde Marie‐Laure , Karan Tania , Mestrovic Ante , Bergman Alanah 
Published: March 2023

AbstractPurposeTo assess dynamic tumor tracking (DTT) target localization uncertainty for in‐vivo marker‐based stereotactic ablative radiotherapy (SABR) treatments of the liver using electronic‐portal‐imaging‐device (EPID) images. The Planning Target Volume (PTV) margin contribution for DTT is estimated.MethodsPhantom and patient EPID images were acquired during non‐coplanar 3DCRT‐DTT delivered on a Vero4DRT linac. A chain‐code algorithm was applied to detect Multileaf Collimator (MLC)‐defined radiation field edges. Gold‐seed markers were detected using a connected neighbor algorithm. For each EPID image, the absolute differences between the measured center‐of‐mass (COM) of the markers relative to the aperture‐center (Tracking Error, (ET)) was reported in pan, tilt, and 2D‐vector directions at the isocenter‐plane.Phantom studyAn acrylic cube phantom implanted with gold‐seed markers was irradiated with non‐coplanar 3DCRT‐DTT beams and EPID images collected. Patient Study: Eight liver SABR patients were treated with non‐coplanar 3DCRT‐DTT beams. All patients had three to four implanted gold‐markers. In‐vivo EPID images were analyzed.ResultsPhantom Study: On the 125 EPID images collected, 100% of the markers were identified. The average ± SD of ET were 0.24 ± 0.21, 0.47 ± 0.38, and 0.58 ± 0.37 mm in pan, tilt and 2D directions, respectively. Patient Study: Of the 1430 EPID patient images acquired, 78% had detectable markers. Over all patients, the average ± SD of ET was 0.33 ± 0.41 mm in pan, 0.63 ± 0.75 mm in tilt and 0.77 ± 0.80 mm in 2D directions The random 2D‐error, σ, for all patients was 0.79 mm and the systematic 2D‐error, Σ, was 0.20 mm. Using the Van Herk margin formula 1.1 mm planning target margin can represent the marker based DTT uncertainty.ConclusionsMarker‐based DTT uncertainty can be evaluated in‐vivo on a field‐by‐field basis using EPID images. This information can contribute to PTV margin calculations for DTT.
Mirror Surface Nanostructuring via Laser Direct Writing—Characterization and Physical Origins
Authors: Vretenar Mario , Puplauskis Marius , Klaers Jan 
Published: March 2023

AbstractThe addition of an optically absorptive layer to otherwise standard dielectric mirrors enables a set of laser direct writing nanostructuring methods that can add functionality to such mirrors while retaining their high reflectivity. A thorough characterization of this method is given in this paper, and its physical origins are investigated. In particular, these measurements show that laser direct writing of such mirrors has a reversible and a permanent component. The reversible process originates from the thermal expansion of the surface and allows a simple yet precise way to temporarily modify the shape of the mirror. Scanning electron microscope cross‐sectional images suggest that the permanent part of the nanostructuring process is due to thermally induced pore formation and enlargement in the tantalum oxide layers of the used dielectric mirror.
Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA‐Seq
Authors: Huang Meng , Xu Shao , Li Yuzhe , Shang Li , Zhan Xiudan , Qin Chaoyin , Su Jun , Zhao Zijin , He Yi , Qin Lina , Zhao Wei , Long Wenyong , Liu Qing 
Published: March 2023

AbstractHigh‐grade meningioma has an unsatisfactory outcome despite surgery and postoperative radiotherapy; however, the factors driving its malignancy and recurrence remain largely unknown, which limits the development of systemic treatments. Single‐cell RNA sequencing (scRNA‐Seq) technology is a powerful tool for studying intratumoral cellular heterogeneity and revealing the roles of various cell types in oncogenesis. In this study, scRNA‐Seq is used to identify a unique initiating cell subpopulation (SULT1E1+) in high‐grade meningiomas. This subpopulation modulates the polarization of M2‐type macrophages and promotes meningioma progression and recurrence. A novel patient‐derived meningioma organoid (MO) model is established to characterize this unique subpopulation. The resulting MOs fully retain the aggressiveness of SULT1E1+ and exhibit invasiveness in the brain after orthotopic transplantation. By targeting SULT1E1+ in MOs, the synthetic compound SRT1720 is identified as a potential agent for systemic treatment and radiation sensitization. These findings shed light on the mechanism underlying the malignancy of high‐grade meningiomas and provide a novel therapeutic target for refractory high‐grade meningioma.
Developing and authenticating an electronic health record–based report card for assessing residents' clinical performance
Authors: Sebok‐Syer Stefanie S. , Dukelow Adam M. , Sedran Robert , Shepherd Lisa , McConnell Allison , Shaw Jennifer M. , Lingard Lorelei 
Published: March 2023

AbstractPurposeThe electronic health record (EHR) is frequently identified as a source of assessment data regarding residents' clinical performance. To better understand how to harness EHR data for education purposes, the authors developed and authenticated a prototype resident report card. This report card used EHR data exclusively and was authenticated with various stakeholders to understand individuals' reactions to and interpretations of EHR data when presented in this way.MethodsUsing principles derived from participatory action research and participatory evaluation, this study brought together residents, faculty, a program director, and medical education researchers (n = 19) to develop and authenticate a prototype report card for residents. From February to September 2019, participants were invited to take part in a semistructured interview that explored their reactions to the prototype and provided insights about how they interpreted the EHR data.ResultsOur results highlighted three themes: data representation, data value, and data literacy. Participants varied in terms of the best way to present the various EHR metrics and felt pertinent contextual information should be included. All participants agreed that the EHR data presented were valuable, but most had concerns about using it for assessment. Finally, participants had difficulties interpreting the data, suggesting that these data could be presented more intuitively and that residents and faculty may require additional training to fully appreciate these EHR data.ConclusionsThis work demonstrated how EHR data could be used to assess residents' clinical performance, but it also identified areas that warrant further consideration, especially pertaining to data representation and subsequent interpretation. Providing residents and faculty with EHR data in a resident report card was viewed as most valuable when used to guide feedback and coaching conversations.
Serving conservation from reef to plate: Barriers and opportunities for invasive lionfish consumption in restaurants
Authors: Smith Nathan , Burgess Kate , Clements Kaylin R. , Burgess Joanne C. , Lavoie Anna , Solomon Jennifer N. 
Published: March 2023

Abstract

Invasive lionfish (Pterois volitans, Pterois miles), introduced to Florida in the 1980s, colonized coral reef ecosystems in the western Atlantic and have been documented beyond recreational diving depths. In addition to threatening coral reef ecosystems, invasive lionfish have been linked to economic damage in the form of reduced native fish yields for local fishers and high management costs incurred in the physical removal of lionfish.
While few examples exist of successful management of marine invasive species, studies show that lionfish removal can mitigate their harmful impacts. One promising market‐based approach that offers benefits to both human livelihoods and marine ecosystems is increasing the demand for the consumption of lionfish. This study focuses on Florida's consumptive lionfish market and fills a gap in understanding of the lionfish supply chain for Florida's restaurant industry.
Twenty culinary professionals in Florida were interviewed to determine their perceptions of barriers and opportunities for increasing their use of lionfish. The most commonly identified barriers were price and consistency of supply, while the most prominent opportunities were improved awareness and culinary potential. Conservation managers, culinary professionals and policymakers should leverage these findings to facilitate opportunities, address barriers and promote public education about invasive lionfish and their impacts.
Flow injection assays for NADH and ethanol using photosensitized rose bengal and luminol–copper (II) chemiluminescence system
Authors: Asghar Muhammad , Yaqoob Mohammad , Ali Samar , Waseem Amir 
Published: March 2023

AbstractThe online photoreaction of the rose bengal photosensitized luminol–copper (II) chemiluminescence (CL) system was used for the determination of β‐nicotinamide adenine dinucleotide (NADH) and ethanol (EtOH) in pharmaceutical formulations combined with a flow injection technique. NADH can significantly enhance the CL emission of the reaction. For EtOH, alcohol dehydrogenase in soluble form was utilized in the presence of nicotinamide adenine dinucleotide resulting in NADH production. The limit of detection (3σ blank, 𝑛 = 3) of 4.0 × 10−8 and 2.17 × 10−5 M, and linear range 1.3 × 10−7 to 2.5 × 10−5 M (R2 = 0.9998, n = 6) and 0.11–2.17 × 10−3 M (R2 = 0.9996, n = 6) were obtained for NADH and EtOH respectively. The injection rate was 100 h−1 with a relative standard deviation (n = 3) of 1.5–4.8% in the range studied for both analytes. The procedure was satisfactorily applied to pharmaceutical formulations with recoveries in the range 91.6 ± 3.0% to 110 ± 2.0% for NADH and 88 ± 3.0% to 95.4 ± 4.0% for EtOH. The results obtained were very consistent and did not differ considerably from the reported approaches at a 95% confidence limit. The possible mechanism of the CL reaction is also explained briefly.
Experiences of psychotherapists transitioning to private practice during COVID‐19
Authors: Duquette Christine L. , Morgan Stephanie M. 
Published: March 2023

AbstractThe purpose of this qualitative phenomenological study was to gain insight into the lived experiences of psychotherapists transitioning to private practice during the COVID‐19 pandemic. With an ever‐expanding need for targeted and accessible mental health care, it is vital to understand this phenomenon and how it impacted patient access and care, and the providers themselves. Eighteen licensed psychotherapists were interviewed and their responses highlighted meaningful professional and clinical implications. As a result of the participant interviews, three major themes were identified: (1) the unknown related to COVID‐19, (2) ease of transition and (3) work–life balance. Eleven additional subthemes emerged. Results suggested that psychotherapists had various personal and professional stressors exacerbated by the pandemic, along with a desire to balance work and life, manage the changes brought on by the pandemic, and gain or retain autonomy in their professional careers. Ultimately, the results of the study point to some shared experiences among psychotherapists, potential issues of access to psychotherapy, issues related to career satisfaction among psychotherapists, as well as some important areas for future research.
Muss Rewind Therapy to alleviate symptoms related to some form of traumatic experience: A thematic analysis of participants' experiences and their perceived effectiveness of MRT
Authors: Hartford Lisa , Horrocks Matthew 
Published: March 2023

AbstractSometimes referred to as a memory reconsolidation treatment, Muss Rewind Therapy (MRT) is a brief psychological intervention which has shown promise in treating symptoms related to some forms of traumatic experience. This study aimed at adding to minimal existing research by exploring the experiences of UK participants who have chosen to self‐refer for MRT for help with symptoms they attributed to some form of previous traumatic experience. Ten participants were interviewed online, and qualitative data were collected using video recordings and transcription. A semistructured framework was employed to explore participants' individual experiences of MRT. All participants rated MRT as helping alleviate the symptoms they related to a previous traumatic experience. Several key themes emerged regarding the participants' experiences of the treatment, including the overall role of the therapist; participants being at the end of their tether before seeking help; experiencing negative emotions during the intervention; repetition of the MRT process in the therapy room; and experiencing some positive outcomes. However, it was unclear whether positive impacts reported after MRT were due specifically to MRT or nonspecific therapy factors because of variations in the way the MRT protocol was delivered and inclusion of other techniques in or before the MRT sessions. Whilst more rigorous research is needed, including research which follows a strict protocol when MRT is provided, to compare MRT versus control group, this novel addition to the existing research, which looks at clients' perspectives on their experiences and their perceived effectiveness of MRT, can add to and inform further research development.
Congenital abnormalities of heart and kidney
Authors: Takafuji Hiroya , Kato Nahoko , Azumi Yuta , Obunai Kotaro 
Published: March 2023

AbstractPatients with congenital anomalies of the kidney and urinary tract (CAKUT) may be at risk for congenital cardiac defects or cardiomyopathies as comorbidities. It is crucial to recognize the coexistence of cardiac abnormalities and CAKUT and recommend screening for cardiac involvement in CAKUT patients using echocardiography.
Star polyethylenes by coordinative polymerization
Authors: Ye Zhibin , Subramanian Ramesh 
Published: March 2023

AbstractWith their distinct star architecture, star polymers show some desirable materials properties and have received extensive research interest. To date, the advancements in living anionic and controlled radical polymerization techniques have empowered the versatile synthesis of a variety of star polymers from several groups of monomers that are amenable to these polymerization techniques. Despite the fact that polyethylene is the largest produced commodity polymer worldwide, the synthesis of star polyethylenes as a unique polyethylene grade has somehow lagged due to the limited availability of powerful transition metal catalysts that can effectively facilitate ‘living’ ethylene polymerization for the construction of star architectures. Nevertheless, some progress had been made over the past two decades. In this review, we attempt to summarize the developments in the area, with an emphasis on synthesis strategies.
Alternanthera flavescens (Amaranthaceae), a new addition to Flora of India
Authors: Sindhu Arya , Venugopalan Nair Saradamma Anil Kumar 
Published: March 2023

AbstractSome populations identifiable as Alternanthera flavescens were discovered in the Kerala region (SE‐India), representing the first record of the national Flora. A macro‐ and micro‐morphological description based on the plants found, as well as ecological notes, are given. The phenotypic plasticity observed was also discussed.