bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children’s Oncology Group
Authors: Erbe Amy K , Diccianni Mitch B , Mody Rajen , Naranjo Arlene , Zhang Fan F , Birstler Jen , Kim KyungMann , Feils Arika S , Hung Jung-Tung , London Wendy B , Shulkin Barry L , Mathew Varsha , Parisi Marguerite T , Servaes Sabah , Asgharzadeh Shahab , Maris John M , Park Julie , Yu Alice L , Sondel Paul M , Bagatell Rochelle 
Published: February 2023

BackgroundIn the Children’s Oncology Group ANBL1221 phase 2 trial for patients with first relapse/first declaration of refractory high-risk neuroblastoma, irinotecan and temozolomide (I/T) combined with either temsirolimus (TEMS) or immunotherapy (the anti-GD2 antibody dinutuximab (DIN) and granulocyte macrophage colony stimulating factory (GM-CSF)) was administered. The response rate among patients treated with I/T/DIN/GM-CSF in the initial cohort (n=17) was 53%; additional patients were enrolled to permit further evaluation of this chemoimmunotherapy regimen. Potential associations between immune-related biomarkers and clinical outcomes including response and survival were evaluated.MethodsPatients were evaluated for specific immunogenotypes that influence natural killer (NK) cell activity, including killer immunoglobulin-like receptors (KIRs) and their ligands, Fc gamma receptors, and NCR3. Total white cells and leucocyte subsets were assessed via complete blood counts, and flow cytometry of peripheral blood mononuclear cells was performed to assess the potential association between immune cell subpopulations and surface marker expression and clinical outcomes. Appropriate statistical tests of association were performed. The Bonferroni correction for multiple comparisons was performed where indicated.ResultsOf the immunogenotypes assessed, the presence or absence of certain KIR and their ligands was associated with clinical outcomes in patients treated with chemoimmunotherapy rather than I/T/TEMS. While median values of CD161, CD56, and KIR differed in responders and non-responders, statistical significance was not maintained in logistic regression models. White cell and neutrophil counts were associated with differences in survival outcomes, however, increases in risk of event in patients assigned to chemoimmunotherapy were not clinically significant.ConclusionsThese findings are consistent with those of prior studies showing that KIR/KIR-ligand genotypes are associated with clinical outcomes following anti-GD2 immunotherapy in children with neuroblastoma. The current study confirms the importance of KIR/KIR-ligand genotype in the context of I/T/DIN/GM-CSF chemoimmunotherapy administered to patients with relapsed or refractory disease in a clinical trial. These results are important because this regimen is now widely used for treatment of patients at time of first relapse/first declaration of refractory disease. Efforts to assess the role of NK cells and genes that influence their function in response to immunotherapy are ongoing.Trial registration numberNCT01767194.
Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: results from phase II study, BTCRC-GU15-023
Authors: Joshi Monika , Tuanquin Leonard , Zhu Junjia , Walter Vonn , Schell Todd , Kaag Matthew , Kilari Deepak , Liao Jiangang , Holder Sheldon L , Emamekhoo Hamid , Sankin Alexander , Merrill Suzzane , Zheng Hong , Warrick Joshua , Hauke Ralph , Gartrel Benjamin , Stein Mark , Drabick Joseph , Degraff David J , Zakharia Yousef 
Published: February 2023

BackgroundPatients with bladder cancer (BC) who are cisplatin ineligible or have unresectable disease have limited treatment options. Previously, we showed targeting programmed death-ligand 1 (PD-L1) with durvalumab (durva) and radiation therapy (RT) combination was safe in BC. We now report results from a phase II study evaluating the toxicity and efficacy of durva and RT in localized BC.MethodsThis is a single-arm, multi-institutional phase II study; N=26. Enrolled patients had pure or mixed urothelial BC (T2-4 N0-2 M0) with unresectable tumors and were unfit for surgery or cisplatin ineligible. Patients received durva concurrently with RT ×7 weeks, followed by adjuvant durva × 1 year.Primary endpoints: (A) progression-free survival (PFS) at 1 year and (B) disease control rate (DCR) post adjuvant durva. Key secondary endpoints: (A) complete response (CR) post durvaRT (8 weeks), (B) overall survival (OS), (C) PFS and (D) toxicity. Correlative studies included evaluation of baseline tumor and blood (baseline, post durvaRT) for biomarkers.ResultsMedian follow-up was 27 months. Evaluable patients: 24/26 post durvaRT, 22/26 for DCR post adjuvant durva, all patients for PFS and OS. Post adjuvant durva, DCR was seen in 72.7%, CR of 54.5%. 1-year PFS was 71.5%, median PFS was 21.8 months. 1-year OS was 83.8%, median OS was 30.8 months. CR at 8 weeks post durvaRT was 62.5%. Node positive (N+) patients had similar median PFS and OS. DurvaRT was well tolerated. Grade ≥3 treatment-related adverse events: anemia, high lipase/amylase, immune-nephritis, transaminitis, dyspnea (grade 4-COPD/immune), fatigue, rash, diarrhea and scleritis. No difference in outcome was observed with PD-L1 status of baseline tumor. Patients with CR/PR or SD had an increase in naïve CD4 T cells, a decrease in PD-1+CD4 T cells at baseline and an increase in cytokine-producing CD8 T cells, including interferon gamma (IFNγ) producing cells, in the peripheral blood.ConclusionDurva with RT followed by adjuvant durva was safe with promising efficacy in localized BC patients with comorbidities, including N+ patients. Larger randomized studies, like S1806 and EA8185, are needed to evaluate the efficacy of combining immunotherapy and RT in BC.Trial registration numberNCT02891161.
Mesoproterozoic basins (Yukon, Canada) in the evolution of supercontinent Columbia
Authors: Medig K.P.R. , Thorkelson D.J. , Turner E.C. , Rainbird R.H. , Gibson H.D. , Marshall D.D. 
Published: February 2023

Geochemical and geochronological data from the Pinguicula Group and unit PR1 of the lower Fifteenmile Group (Yukon, Canada) provide information on sediment provenance and timing of break-up of supercontinent Columbia and seaway development on Laurentia’s northwestern margin. The older unit PR1, in the Coal Creek inlier, has a near-unimodal detrital zircon population with an age of 1499 ± 3 Ma. The Pinguicula Group detrital zircon data, in the Wernecke and Hart River inliers, display a polymodal detrital zircon population with a maximum age of <1322 ± 23 Ma. Using detrital zircon signatures, Sm–Nd isotopic data, and C-isotopic signatures, lithostratigraphic correlations between the Pinguicula Group in the Wernecke and Hart River inliers are confirmed, whereas the Pinguicula Group and unit PR1 are no longer considered correlative. The zircon population in unit PR1 requires a proximal source, but sources of this age are not known in western Laurentia. Based on detrital zircon and Sm–Nd data, sediment in unit PR1 was derived from the Mt. Isa inlier in northeastern Australia sometime after 1460 Ma. Unit PR1 correlates with older Mesoproterozoic successions, including the Belt-Purcell, that were deposited during break-up of supercontinent Columbia, and contain sediment from Australia and the Mawson continent. Mesoproterozoic successions deposited after 1.45 Ga, including the Missoula Group, lack North American Magmatic Gap (NAMG)-aged zircon and instead record sediment provenance from southern Laurentia, as north Australia and the Mawson continent rifted from Laurentia’s western margin. The Pinguicula Group has few NAMG-aged grains that were probably recycled from older Mesoproterozoic basins.
Quantifying genetic differentiation and population assignment between two contingents of Atlantic mackerel (Scomber scombrus) in the Northwest Atlantic
Authors: Bourret Audrey , Smith Andrew , Van Beveren Elisabeth , Plourde Stéphane , Curti Kiersten L. , Jansen Teunis , Richardson David E. , Castonguay Martin , Rodriguez-Ezpeleta Naiara , Parent Geneviève J. 
Published: February 2023

In the Northwest Atlantic (NWA), the Atlantic mackerel ( Scomber scombrus) has a northern and a southern contingent, which spawn in Canada and the United States (U.S.), respectively. Both contingents mix mostly along the U.S. shelf during overwintering. The discrimination of individuals from each contingent in fisheries could improve the management of this depleted species in both countries. Here, we used genome-wide markers (>10 000 single nucleotide polymorphisms (SNPs)) to assess genomic differences between mackerel of both contingents, and possibly infer the proportions of each contingent in NWA management units. Small but significant genetic differentiation was observed between the northern and southern contingents ( FST = 0.0010). Genetic assignments to reference samples from the two contingents were performed with predictive accuracy > 85%. Fish from both contingents were present along the U.S. shelf during late winter and early spring but also, without prior evidence of this, likely in Canadian waters from late spring to fall. Genetic assignments could be used as a stock discrimination tool so that fishery removals can be effectively determined and managed on a contingent level.
Planting The Seeds of Gratitude for Sustainable Corporate Social Responsibility and The Quality of Life
Authors: Ong Cordero Ernesto 
Published: February 2023

The study sought to determine the implementation of CSR activities and their effects on the beneficiaries' quality of life.
This study used mixed-method research, combining quantitative correlational and qualitative analysis. In addition, it utilized statistical tools such as frequency, percentage, mean, weighted mean, and regression analysis.
The research instrument was standardized and adopted from Kim, Uysal, and Sirgy's (2012) study entitled" How does tourism in a community impact the quality of life of community residents?"
The interview used guide questions to direct the responses of the respondents. The study's subject is the 400 beneficiaries of the Southern Mindanao plantation communities.
The findings revealed that the company's economic, social, cultural, and environmental CSR activities were implemented to a moderate extent. On the other hand, the beneficiaries' quality of life regarding life satisfaction under various conditions, level of life satisfaction, and satisfaction level on health and safety were categorized as reasonably satisfied.
The CSR factors, such as economic, social, and cultural, were not statistically significant to claim their influence on the community's quality of life. However, though environmental factors significantly influence the community's quality of life, the extent or magnitude of its influence cannot have a significant effect as its beta coefficient is at 0.65, indicating a weak effect.
Considering the findings and conclusions of the study, the following recommendations were suggested: 1. To offer more information or seminars on the preservation of the natural environment. 2. To conduct regular tree planting in the community to improve the environment and help reduce temperature, produce clean air, reduce greenhouse gasses, and prevent flooding and soil erosion. 3. To teach the community proper waste disposal at home through Green Alternatives, the Five R's Reduce, Reuse, Repair, Rot, and Recycle. 4. To determine program services that will change and expand the community/students' needs. 5. To conduct a workshop on CSR's goals and objectives to increase the level of awareness of the beneficiaries on the accurate picture of CSR in their lives, 6. For the companies/administrators to apply the proposed strategic approaches in enhancing the CSR programs to their beneficiaries.
Reexamining and Reimagining the Future of Barangay (Village) Nagbalon: Solidarity Program and Community Based Enterprise Approaches for the Local Governance of the Sustainable Development Goals
Authors: Valenzuela Victoria P. , Batac Joseph H. , Parinas Sherwin S. 
Published: February 2023

The UN SDG for performance measures is already in place that makes the Barangay Solidarity Program build to address one of the issues which are ageism. In today’s changing society, not only changing values are important, but also changing the numbers and mindset of the people. Old persons have seen many changes in their lives, and the changes associated with aging are taken pretty much in stride. This study examines the real happiness of older persons, the expectations that society has for them, how people adapt to future forces in later life. The study employed a mixed-method approach. The successful aging dimensions were reviewed among older persons. A quantitative survey among 200 older persons and exploratory factor analysis was applied to test the structural validity of the instrument. This includes the ten dimensions of happiness namely: food, family, friends, faculty, fitness, financial, faith, future, and fear. In addition, this study explores that the older persons of the future may have no choice but to be self-reliant. The obtained results indicated that the happiness of older persons has significant effects on their faculty, faith, and future singly and in the combination of moderating variables such as age, gender, and pension. The different stakeholders' collaboration, co-production, and co-creation should be realized to meet the challenges on what the people feel, need, and get involved in their resilient bright future and capacity building as part of community-based enterprises. For future undertakings, other researchers may consider government organizations as co-leadership, and co-organizers of every barangay success for aging society, pandemic crisis and disaster preparedness, and economic enterprises at individual and social levels for sustainable development goals of local governance.
Seaborne Patrollers Performance Evaluation: A Framework for A Proposed Development Plan
Authors: Tutaan Mary Jaemee Lauren , Bakingkito PLT Rochelle G , Atanacio Precious F. , Dauis Dennis Victor S. , Malang Bernandino P. , Vigonte Florinda G. 
Published: February 2023

The study focused on the analysis of the work performance of the seaborne patrollers through their individual performance evaluation reports. The study aimed to evaluate the overall performance standing of the police officers in terms of their output, core competencies, and personal qualities which would be the basis for a proposed developmental framework that would maximize the capacity and capability of the personnel of the PNP Maritime Group. The respondents of the study were the police officers of the PNP Maritime Group in the municipality of Pangasinan composed of sixty-six (66) police non-commissioned officers and nine (9) police commissioned officers. The researcher used the descriptive method of research to obtain factual and quality data and aided the researchers in describing and explaining the current situation. The researchers used Individual Performance Evaluation Report (IPER) to measure the respondents' work and personal qualities. The data was manually encoded by the researchers using Microsoft Excel accurately to attain descriptive validity. Upon analyzing the gathered data, it was found that the high level of scores extracted from the respondents' Individual Performance Evaluation Report (IPER) is highly capable of their mandate as police officers. There are also enhancements presented in the study that needs to be integrated with the need to be integrated with the existing program to create opportunities to develop personal and professional qualities. In turn, this better and more responsive organization. Among the recommendations observed in the study are the following: maintaining the practice of the Individual Performance Evaluation Report (IPER); adopting the developmental plan; crafting the scorecard as an instrument that would translate the aspects of the Individual Performance Evaluation Report (IPER) into a more understandable and detailed plan for the development of the individual; implementing refresher course and orientation for new police officers on the importance of Individual Performance Evaluation Report (IPER) not only as compliance at work but more so as an instrument to grow and develop personally and professionally; the implementation of the Individual Performance Evaluation Report (IPER) program must be further studied in terms of process and evaluation; there must be a holistic evaluation and monitoring process for every project or program in connection with the Individual Performance Evaluation Report (IPER), and lastly, there must be a program to monitor the effectiveness of the Individual Performance Evaluation Report (IPER) as time continues, checking on its relevance, and looking for weak points to improve and strong points to standardize.
Challenges and Opportunities Encountered by the Master of Arts in Educa-tion (MAED) Students in Cotabato City
Authors: Dangalao Tong Kabenbelan 
Published: February 2023

This study aimed to determine the needs and problems in conducting research among the MAED students of Higher Education Institutions in Cotabato City Graduate Schools. It utilized the descriptive–quantitative type of research, and it was conducted in the selected college and universities-graduate schools in Cotabato City. The study's respondents were the forty-four (44) Master of Arts in Education graduating students for 2015-2016. The study employed total enumeration as a sampling technique. A survey questionnaire was generated upon reviewing the related literature and other secondary sources such as research articles and journals. The study's statistical tools used frequency and percentage counts, mean, and the grand mean.
The needs of the MAED students in conducting research were perceived as "needed," while the level of difficulties encountered by the MAED students was perceived as "difficult."
Financial aspects were seen as a hindrance to their research work. Likewise, a school offering graduate college in the city has equipped a library to give students access to the research materials they need. Similarly, there is still a need to develop the student's skills in conducting research. Students conducting research were it hard to manage their time while most of them were married and at the same time working.
It is recommended that research subjects be emphasized to students taking research courses. There should be an organized schedule for students to consult closely with their adviser. The graduate studies program in the city should strengthen its research program.
Mean State AMOC Affects AMOC Weakening through Subsurface Warming in the Labrador Sea
Authors: Lin Yuan-Jen , Rose Brian E. J. , Hwang Yen-Ting 
Published: February 2023

Abstract
While most models agree that the Atlantic meridional overturning circulation (AMOC) becomes weaker under greenhouse gas emission and is likely to weaken over the twenty-first century, they disagree on the projected magnitudes of AMOC weakening. In this work, CMIP6 models with stronger climatological AMOC are shown to project stronger AMOC weakening in both 1% ramping CO2 and abrupt CO2 quadrupling simulations. A physical interpretation of this result is developed. For models with stronger mean state AMOC, stratification in the upper Labrador Sea is weaker, allowing for stronger mixing of the surface buoyancy flux. In response to CO2 increase, surface warming is mixed to the deeper Labrador Sea in models with stronger upper-ocean mixing. This subsurface warming and corresponding density decrease drives AMOC weakening through advection from the Labrador Sea to the subtropics via the deep western boundary current. Time series analysis shows that most CMIP6 models agree that the decrease in subsurface Labrador Sea density leads AMOC weakening in the subtropics by several years. Also, idealized experiments conducted in an ocean-only model show that the subsurface warming over 500–1500 m in the Labrador Sea leads to stronger AMOC weakening several years later, while the warming that is too shallow (<500 m) or too deep (>1500 m) in the Labrador Sea causes little AMOC weakening. These results suggest that a better representation of mean state AMOC is necessary for narrowing the intermodel uncertainty of AMOC weakening to greenhouse gas emission and its corresponding impacts on future warming projections.
How Little Does It Take to Trigger a Peer Effect? An Experiment on Crime as Conditional Rule Violation
Authors: Engel Christoph 
Published: February 2023

Objectives Peer effects on the decision to commit a crime have often been documented. But how little does it take to trigger the effect? Method A fully incentivized, anonymous experiment in the tradition of experimental law and economics provides fully internally valid causal evidence. A companion vignette study with members of the general public extends external validity. Results (a) the more of their peers violate an arbitrary rule, the more participants do; (b) a minority has a threshold and switches from rule-abiding to violation once a sufficient number of their peers violate the rule; (c) the more the rule is constraining, the more participants are sensitive to the number of others who violate the rule; (d) if participants do not have explicit information about the incidence of rule violations in their community, they rely on their beliefs. Conclusion In terms of substance, the paper shows that mere social information is the core of peer effects. In terms of methodology, the paper demonstrates the power of incentivized, decontextualized lab experiments for isolating mental building blocks of the decision to commit a crime.
Early career demanding psychosocial work environment and severe back pain and neck/shoulder pain in experienced nurses: A cohort study
Authors: Sundberg Tobias , Skillgate Eva , Gustavsson Petter , Rudman Ann 
Published: February 2023

Aims: Back pain and neck/shoulder pain are common among nurses. The aim of this study was to investigate the association between nurses’ exposure to a demanding psychosocial work environment during the first three years after graduation and the occurrence of severe back pain and neck/shoulder pain in the longer term, 11–15 years later. Methods: The Longitudinal Analysis of Nursing Education (LANE) study (nursing graduates from 26 Swedish universities in the years 2002, 2004 and 2006) was used to create two risk cohorts of nurses not reporting severe back pain ( n=1764) or neck/shoulder pain ( n=1707). Nurses exposed to a demanding psychosocial work environment for one, two or three of the first three years in their career were compared to nurses not having a demanding psychosocial work environment for any of these three years regarding the incidence of severe back pain or neck/shoulder pain at follow-up, 11–15 years later. Relative risks (RR) with 95% confidence intervals (CI) were calculated using binomial regression. Results: The RR (95% CI) of having severe back pain for nurses who had a demanding psychosocial work environment for one of the three years was 1.36 (0.82–2.28) and 2.08 (1.21–3.57) for two of the three years and 2.82 (1.43–5.55) for all three years. Corresponding RRs (95% CIs) for severe neck/shoulder pain were 1.35 (0.87–2.10), 1.49 (0.88–2.51) and 1.41 (0.62–3.20), respectively. Conclusions: Nurses who were repeatedly exposed to a demanding psychosocial work environment early in their career reported severe back pain to a higher extent in the longer term.