bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axl alleviates DSS-induced colitis by preventing dysbiosis of gut microbiota
Authors: Yee Su-Min , Choi Harim , Seon Jeong-Eun , Ban Yu-Jin , Kim Min-Jae , Seo Jae-Eun , Seo Ja Hun , Kim Sehyeon , Moon Seo Hee , Yun Chul-Ho , Lee Hyang Burm , Kang Hyung-Sik 
Published: April 2023

AbstractAxl is a tyrosine kinase receptor, a negative regulator for innate immune responses and inflammatory bowel disease (IBD). The gut microbiota regulates intestinal immune homeostasis, but the role of Axl in the pathogenesis of IBD through the regulation of gut microbiota composition remains unresolved. In this study, mice with DSS-induced colitis showed increased Axl expression, which was almost entirely suppressed by depleting the gut microbiota with antibiotics. Axl−/− mice without DSS administration exhibited increased bacterial loads, especially the Proteobacteria abundant in patients with IBD, significantly consistent with DSS-induced colitis mice. Axl−/− mice also had an inflammatory intestinal microenvironment with reduced antimicrobial peptides and overexpression of inflammatory cytokines. The onset of DSS-induced colitis occurred faster with an abnormal expansion of Proteobacteria in Axl−/− mice than in WT mice. These findings suggest that a lack of Axl signaling exacerbates colitis by inducing aberrant compositions of the gut microbiota in conjunction with an inflammatory gut microenvironment. In conclusion, the data demonstrated that Axl signaling could ameliorate the pathogenesis of colitis by preventing dysbiosis of gut microbiota. Therefore, Axl may act as a potential novel biomarker for IBD and can be a potential candidate for the prophylactic or therapeutic target of diverse microbiota dysbiosis-related diseases.
Corneal higher-order aberrations in corneal endothelial decompensation secondary to obstetric forceps injury
Authors: Kasamatsu Hirotsugu , Yagi-Yaguchi Yukari , Yamaguchi Takefumi , Nishisako Sota , Murata Toshinori , Shimazaki Jun 
Published: April 2023

AbstractForceps corneal injuries during infant delivery cause Descemet membrane (DM) breaks, that cause corneal astigmatism and corneal endothelial decompensation. The aim of this study is to characterise corneal higher-order aberrations (HOAs) and corneal topographic patterns in corneal endothelial decompensation due to obstetric forceps injury. This retrospective study included 23 eyes of 21 patients (54.0 ± 9.0 years old) with forceps corneal injury, and 18 healthy controls. HOAs and coma aberrations were significantly larger in forceps injury (1.05 [0.76–1.98] μm, and 0.83 [0.58–1.69], respectively) than in healthy controls (0.10 [0.08–0.11], and 0.06 [0.05–0.07], respectively, both P < 0.0001). Patient visual acuity was positively correlated with coma aberration (rs = 0.482, P = 0.023). The most common topographic patterns were those of protrusion and regular astigmatism (both, six eyes, 26.1%), followed by asymmetric (five eyes, 21.7%), and flattening (four eyes, 17.4%). These results indicate that increased corneal HOAs are associated with decreased visual acuity in corneal endothelial decompensation with DM breaks and corneal topography exhibits various patterns in forceps injury.
Optimisation of collaborative supply transportation based on traffic road network topology
Authors: Wang Aihui , Han Xiaobo , Liao Wudai , Liu Ping , Song Jingwen , Li Daming 
Published: April 2023

AbstractWith the rapid development of China's economy, enterprises need to plan their logistics transportation routes reasonably in advance. This will make the transportation service more efficient. For the supplier's transportation service problem, an analysis method of critical path nodes is provided and a multi‐supplier collaborative transportation strategy is designed in this article. First, a model for minimising the transportation cost was established, then a path diagram was simulated and the optimal and alternative transportation paths of suppliers based on the k‐shortest path algorithm were calculated. In addition, path node availability during COVID‐19 is used as a research context in this article. A multi‐stage path analysis method was provided by discussing different cases of critical path nodes, which can make a reasonable selection of paths in a timely and effective manner. Finally, simulations of collaborative transportation for suppliers were performed in three scenarios and the results verified the effectiveness of the collaborative transportation strategy. The proposed collaborative transportation strategy of suppliers not only strengthened the synergistic cooperation among suppliers, but also cultivated the potential customer for suppliers in this article. Furthermore, the strategy could improve the flexibility of the supply chain, maximise the overall efficiency and also provide a new solution for the development of logistics and transportation services.
CNN‐based received signal strength prediction: A frequency conversion scheme
Authors: Huang Siyi , Zhang Xingqi 
Published: April 2023

AbstractTo support the design and deployment of emerging high‐frequency wireless systems in various applications such as intelligent transportation, advanced received signal strength (RSS) simulation tools for radio coverage prediction are needed. In railway transportation, the vector parabolic equation (VPE) method is a commonly used approach for radio wave propagation modelling in large guiding structures such as tunnels. However, running VPE simulations at high frequencies in such an environment is computationally expensive, as the discretization parameters are closely related to the wavelength. In this letter, the authors propose a convolutional neural network‐based model that can efficiently provide RSS prediction at high frequencies by leveraging data obtained from VPE simulations at a lower frequency as an anchor. This proposed model can significantly improve the efficiency of VPE for high‐frequency RSS predictions and has been validated against conventional VPE in various tunnel cases.
Eco‐friendly polypropylene power cable insulation: Present status and perspective
Authors: Li Jianying , Yang Kai , Wu Kangning , Jing Zhenghong , Dong Jin‐Yong 
Published: April 2023

AbstractEnvironmental protection is the future trend of power equipment development, and is also a research hotspot in the field of power cable insulation in recent years. Due to the excellent electrical properties and recyclability, polypropylene (PP) based composites are regarded as promising insulating materials for eco‐friendly next‐generation power cables. However, the high modulus and hardness of pure PP make it difficult to be directly employed as cable insulations, which needs to be further optimised. General methods of mechanical performance regulation often result in the deterioration of electrical performance, such as breakdown strength, space charge and so on. Therefore, it is recognised that the major challenge impeding practical applications of PP power cable insulation arises from the synergetic regulation of multi‐performances. The multi‐level structures influencing the multi‐performances of PP are introduced by the authors and the researches on the performance enhancement of PP through nanoscale structure regulation in recent years are reviewed in detail. Seven kinds of modification methods including nano‐doping, chemical grafting, in‐suit copolymerisation, heat treatment, nucleating agent, voltage stabiliser and elastomer blending are paid special attention. Based on the full understanding of the research status, the challenges and issues of future research are put forward for eco‐friendly PP power cable insulation.
Mother of dragons
Authors: Barnes A. T. , Liu J. , Zhang Q. , Tan J. C. , Bigiel F. , Caselli P. , Cosentino G. , Fontani F. , Henshaw J. D. , Jiménez-Serra I. , Kalb D.-S. , Law C. Y. , Longmore S. N. , Parker R. J. , Pineda J. E. , Sánchez-Monge A. , Lim W. , Wang K. 
Published: April 2023

Context. Core accretion models of massive star formation require the existence of massive, starless cores within molecular clouds. Yet, only a small number of candidates for such truly massive, monolithic cores are currently known.
Aims. Here we analyse a massive core in the well-studied infrared-dark cloud (IRDC) called the ‘dragon cloud’ (also known as G028.37+00.07 or ‘Cloud C’). This core (C2c1) sits at the end of a chain of a roughly equally spaced actively star-forming cores near the center of the IRDC.
Methods. We present new high-angular-resolution 1 mm ALMA dust continuum and molecular line observations of the massive core.
Results. The high-angular-resolution observations show that this region fragments into two cores, C2c1a and C2c1b, which retain significant background-subtracted masses of 23 M⊙ and 2 M⊙ (31 M⊙ and 6 M⊙ without background subtraction), respectively. The cores do not appear to fragment further on the scales of our highest-angular-resolution images (0.2″, 0.005 pc ~ 1000 AU). We find that these cores are very dense (nH2 > 106 cm−3) and have only trans-sonic non-thermal motions (ℳs ~ 1). Together the mass, density, and internal motions imply a virial parameter of <1, which suggests the cores are gravitationally unstable, unless supported by strong magnetic fields with strengths of ~1–10 mG. From CO line observations, we find that there is tentative evidence for a weak molecular outflow towards the lower-mass core, and yet the more massive core remains devoid of any star formation indicators.
Conclusions. We present evidence for the existence of a massive, pre-stellar core, which has implications for theories of massive star formation. This source warrants follow-up higher-angular-resolution observations to further assess its monolithic and pre-stellar nature.
Soft gamma-ray spectral and time evolution of the GRB 221009A: Prompt and afterglow emission with INTEGRAL/IBIS-PICsIT
Authors: Rodi James , Ubertini Pietro 
Published: April 2023

Aims. The gamma-ray burst (GRB) 221009A, with its extreme brightness, has provided the opportunity to explore GRB prompt and afterglow emission behavior on short timescales with high statistics. In conjunction with detection up to very-high-energy gamma rays, studies of this event shed light on the emission processes at work in the initial phases of GRBs’ emission.
Methods. Using INTEGRAL/IBIS’s soft gamma-ray detector, PICsIT (200–2600 keV), we studied the temporal and spectral evolution during the prompt phase and the early afterglow period.
Results. We found a “flux-tracking” behavior with the source spectrum “softer” when brighter. However, the relationship between the spectral index and the flux changes during the burst. The PICsIT light curve shows that afterglow emission begins to dominate at ∼T0 + 630 s and decays with a slope of 1.6 ± 0.2, consistent with the slopes reported at soft X-rays.
Manganese-Catalyzed ortho-Hydroalkylation of Aryl-Substituted N-Heteroaromatic Compounds with Maleimides
Authors: Shinde Vikki N. , Bhawani Bhawani , Kumar Anil , Nipate Dhanajay S. , Sonam Sonam , Meena Neha , Rangan Krishnan , Kumar Dalip 
Published: April 2023

AbstractA regioselective manganese-catalyzed ortho-hydroalkylation of aryl-substituted N-heteroaromatic compounds with a range of maleimides is described. The developed C–H bond functionalization protocol allowed the introduction of the succinimide motif at the ortho-position of the aryl ring of N-heteroaromatic compounds, such as 2-arylimidazo[1,2-a]pyridines, 2-arylindazoles, 2-phenylpyridine, 2-phenyl­pyrimidine, 2-phenylimidazo[1,2-a]pyrimidine, 2-phenylimidazo[2,1-b]thiazole, 2-phenylbenzo[d]imidazo[2,1-b]thiazole, 1-phenylindazole and 1-phenylpyrazole, to produce 3-(2-(N-heteroaryl)aryl)pyrrolidine-2,5-diones in good yields. The protocol exhibited broad substrate scope, good functional group tolerance and excellent regioselectivity under mild and additive-free reaction conditions.
Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonyl Fluorides
Authors: Duan Wei-Liang , Cheng An-Qi , Wu Zeng-Hua , Yang Huai-Lan 
Published: April 2023

AbstractA Pd-catalyzed asymmetric phosphination of α,β-unsaturated sulfonyl fluorides was developed, and a series of tertiary phosphorus compounds were obtained in excellent yields and enantioselectivities (up to 99% ee). The chiral adduct can be further converted into chiral phosphine sulfonic acid as the ligand for the arene Ru metal complex.
Long-term outcomes of Zenker’s peroral endoscopic myotomy (Z-POEM) for treatment of Zenker’s diverticulum
Authors: Steinway Steven , Zhang Linda , Amundson Julia , Nieto Jose , Desai Pankaj , Jacques Jeremie , Bejjani Michael , Pioche Mathieu , Kumta Nikhil , Hernandez-Mondragon Oscar , Ujiki Michael , Khashab Mouen 
Published: April 2023

Abstract
Background and study aims Z-POEM is now an established therapy for symptomatic Zenker’s diverticulum (ZD). Short-term follow-up of up to 1-year post Z-POEM suggests excellent efficacy and safety; however, long-term outcomes are not known. Thus, we sought to report on longer-term outcomes (≥ 2 years) following Z-POEM for treatment of ZD.
Patients and methods This was an International multicenter retrospective study at eight institutions across North America, Europe, and Asia over a 5-year period (from December 3, 2015 to March 13, 2020) of patients who underwent Z-POEM for management of ZD with a minimum 2-year follow-up. The primary outcome was clinical success, defined as improvement in dysphagia score to ≤ 1 without need for further procedures during the first 6 months. Secondary outcomes included rate of recurrence in patients initially meeting clinical success, rate of reintervention, and adverse events (AEs).
Results A total of 89 patients (male 57.3 %, mean age 71 ± 12 years) underwent Z-POEM for treatment of ZD (mean diverticulum size was 3.4 ± 1.3 cm). Technical success was achieved in 97.8 % of patients (n = 87) with a mean procedure time of 43.8 ± 19.2 minutes. The median post-procedure hospital stay was 1 day. There were eight AEs (9 %) (3 mild, 5 moderate). Overall, clinical success was achieved in 84 patients (94 %). Mean dysphagia, regurgitation, and respiratory scores all improved dramatically from 2.1 ± 0.8, 2.8 ± 1.3, and 1.8 ± 1.6 pre-procedure to 0.13 ± 0.5, 0.11 ± 0.5, and 0.05 ± 0.4, respectively, post-procedure at most recent follow-up (all P < 0.0001). Recurrence occurred in six patients (6.7 %) during a mean length of follow-up of 37 months (range 24 to 63 months).
Conclusions Z-POEM is a highly safe and effective treatment for Zenker’s diverticulum with durable treatment effect to at least 2 years.
Imaging of Anatomical Variants of the Long Head Biceps Tendon
Authors: Fischetti Michele , Romano Alfonso Maria , Albano Domenico , Di Salvatore Mariano Giuseppe , Sconfienza Luca Maria , Zappia Marcello 
Published: April 2023

AbstractAnatomical variants of the long head of biceps (LHB) tendon are widely discussed in the literature. As one of the few intra-articular tendons, magnetic resonance arthroscopy can quickly evaluate the proximal part of LHB morphology. It provides good assessment of both intra-articular and extra-articular portions of the tendons. In-depth knowledge about imaging of the anatomical LHB variants discussed in this article is useful preoperatively for orthopaedists and also helps avoid potential diagnostic misinterpretations.
Anatomical Variants of the Upper Limb Nerves: Clinical and Preoperative Relevance
Authors: Schwabl Christoph , Hörmann Romed , Strolz Carola Johanna , Drakonaki Elena , Zimmermann Robert , Klauser Andrea Sabine 
Published: April 2023

AbstractProfound knowledge of nerve variations is essential for clinical practice. It is crucial for interpreting the large variability of a patient's clinical presentation and the different mechanisms of nerve injury. Awareness of nerve variations facilitates surgical safety and efficacy. Clinically significant anatomical variations can be classified into two main groups: variability in the course of the nerve and variability of structures surrounding the nerve. In this review article we focus on the most common nerve variants of the upper extremity and their clinical relevance.
Anatomical Variants of the Sacroiliac Joint
Authors: Badr Sammy , Khizindar Huda , Boulil Youssef , Abou Diwan Ralph , Demondion Xavier , Cotten Anne 
Published: April 2023

AbstractAnatomical variants are frequently encountered when assessing the sacroiliac joints (SIJ) using magnetic resonance imaging. When not located in the weight-bearing part of the SIJ, variants associated with structural and edematous changes can be misinterpreted as sacroiliitis. Their correct identification is necessary to avoid radiologic pitfalls. This article reviews five SIJ variants involved in the dorsal ligamentous space (accessory SIJ, iliosacral complex, semicircular defect, bipartite iliac bony plate, and crescent iliac bony plate) and three SIJ variants involved in the cartilaginous part of the SIJ (posterior dysmorphic SIJ, isolated synostosis, and unfused ossification centers).
Ulam–Hyers stability for second-order non-instantaneous impulsive fractional neutral stochastic differential equations
Authors: K. Dhanalakshmi , P. Balasubramaniam 
Published: April 2023

In this paper, sufficient conditions are established for the Ulam–Hyers stability of second-order non-instantaneous impulsive fractional neutral stochastic differential equations (NIIFNSDEs) with supremum norm in the pth means square sense. The existence of solution of NIIFNSDEs is derived by using the cosine family of linear operator, Itô’s formula, and Mönch fixed point theorem in infinite-dimensional space. Finally, an example is demonstrated to illustrate the obtained theoretical results.
Performance of small- and wide-angle x-ray scattering beamline at Indus-2 synchrotron
Authors: Das Avik , Bahadur Jitendra , Kumar Ashwani , Sen Debasis 
Published: April 2023

A Small- and Wide-Angle X-ray Scattering (SWAXS) beamline (BL-18) is installed and commissioned at a 1.5 T bending magnet port (5°) of Indus-2 synchrotron at RRCAT, Indore, India. The ∼40-m-long beamline has tunable x-ray energy in the range of 5–20 keV by using a double crystal monochromator. A 1.5-m-long toroidal mirror is used to focus the x-ray beam at the detector position. The beamline is equipped with a 6-m-long movable detector stage to access different wave-vector transfer ranges. At present, an online image plate area detector and a linear position-sensitive gas detector are installed for Small-Angle X-ray Scattering (SAXS) and Wide-Angle X-ray Scattering (WAXS) measurements, respectively. The beamline is operational in simultaneous SAXS/WAXS mode to probe the mesoscopic as well as molecular level structure over a wide range of wave-vector transfer. The specification of the beamline and its performance are reported here. A few recent experimental results, as obtained from BL-18, are also described in brief.
Focused laser differential interferometry post-processing methodology for flowfields with circular symmetry
Authors: Camillo Giannino Ponchio , Wagner Alexander 
Published: April 2023

An analytic methodology is presented to reconstruct the pressure waveform of flowfields with circular symmetry from the phase shift detected with Focused Laser Differential Interferometry (FLDI). A weak blast wave generated by an electric spark in ambient air is investigated with the proposed approach. Values of separation distance between the differentiating foci of the FLDI Δx of 76, 120, 175, and 252 μm are employed to probe the flowfield at locations between 3 and 50 mm from the spark source. In a subset of these distances, reference measurements of peak pressure obtained with a surface pressure sensor indicate good agreement with the reconstructed data when small separation distances are used. Further analysis of FLDI reconstructed data is conducted using theoretical correlations for N-waves in terms of the distribution of pressure peak amplitude and compression phase as the wave front propagates. Agreement with theory is verified for all differentiation separation distances except the largest, for which peak pressure comparison shows a 10% loss of measured vs predicted value. A computational FLDI is employed to scrutinize the simplifying hypotheses supporting the waveform reconstruction approach. The direct comparison between experimental and computational FLDI output reveals additional discrepancies for intermediate Δx values but very good agreement for the smallest Δx. The proposed methodology is thus verified to be reasonable, upon appropriate minimization of the FLDI differentiation distance. A parametric analysis using computational FLDI indicates the adequate value of FLDI Δx to be 20% or less of the flowfield characteristic length in terms of density gradient.
A new high-pressure high-temperature deformation apparatus to study the brittle to ductile transition in rocks
Authors: Meyer G. G. , Acosta M. , Leclere H. , Morier L. , Teuscher M. , Garrison G. , Schubnel A. , Violay M. 
Published: April 2023

Understanding the micro-mechanisms underlying the localized–ductile transition (LDT) as well as the brittle–plastic transition (BPT) has become crucial for our wider understanding of crustal processes and seismicity. Given how difficult in situ observations of these transitions are to perform, laboratory experiments might be our only way to investigate the processes active under these conditions (high T and high P). Here, we present Triaxial AppaRatus for GEoThermal energy, a new gas-based triaxial apparatus located at EPFL in Switzerland that was specifically designed to operate under conditions where both the LDT and BPT can occur in geomaterials. We show that the machine is capable of deforming rock samples at confining pressures of up to 400 MPa, temperatures of up to 800 °C, and pore pressures (liquid or gas) of up to 300 MPa while keeping the temperature gradient along samples of 40 mm in length and 20 mm in diameter minimal (less than 30 at 700 °C). Most importantly, the maximum load is 1000 kN (stresses as high as 2.2 GPa on 24 mm samples and 3 GPa on 20 mm samples), allowing for the deformation of very competent rock samples. Moreover, during deformation, the pair of syringe pore pressure pumps allow for continuous permeability or dilatancy recording. We benchmarked our machine against existing data in the literature and show that it accurately and precisely records stress, strain, permeability, pressure, and temperature.
High efficiency radio frequency antennas for amplifier free quantum sensing applications
Authors: Mahtab S. , Milas P. , Veal D.-T. , Spencer M. G. , Ozturk B. 
Published: April 2023

Radio frequency (RF) signals are frequently used in emerging quantum applications due to their spin state manipulation capability. Efficient coupling of RF signals into a particular quantum system requires the utilization of carefully designed and fabricated antennas. Nitrogen vacancy (NV) defects in diamond are commonly utilized platforms in quantum sensing experiments with the optically detected magnetic resonance (ODMR) method, where an RF antenna is an essential element. We report on the design and fabrication of high efficiency coplanar RF antennas for quantum sensing applications. Single and double ring coplanar RF antennas were designed with −37 dB experimental return loss at 2.87 GHz, the zero-field splitting frequency of the negatively charged NV defect in diamond. The efficiency of both antennas was demonstrated in magnetic field sensing experiments with NV color centers in diamond. An RF amplifier was not needed, and the 0 dB output of a standard RF signal generator was adequate to run the ODMR experiments due to the high efficiency of the RF antennas.