bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal Metastases with Intrabiliary Growth: incidence, treatment and outcomes
Authors: Langella Serena , Armentano Serena , Russolillo Nadia , Luzzi Andrea-Pierre , Fontana Andrea Pierluigi , Ferrero Alessandro 
Published: March 2023

Abstract
Purpose: intrabiliary growth (IG) is an unusual modality for colorectal metastases to spread. Relatively little is known about this condition because large series are lacking. The aim of the study was to compare the surgical and oncological outcomes of patients with or without IG.
Methods: From 01/2010 to 12/2020, 999 patients underwent hepatectomy for colorectal metastases. Clinicopathological variables were retrospectively analysed from a prospective-collected database of patients with or without IG.
Results: At first hepatectomy, 29 patients (2.9%) had IG: 7 isolated IG and 22 mixed-type (mass-forming lesion with IG). 4 patients presented IG at repeat hepatectomy for recurrence, of whom 3 had no biliary invasion at initial surgery. IG resulted to be more common in older patients (median age 70 in IG vs 60 years of no-IG, p=0.004). Mean time from colorectal tumour was longer in IG (20.4 months) than no-IG (12.9 months), p=0.038. Major hepatectomies (55.2% IG vs 29.7% no-IG, p=0.003) and anatomic resections (89.7% vs 58.2%, p=0.001) were more frequently required to treat IG. In 5 (17%) of IG a resection of main bile duct was performed. Overall postoperative mortality and complications were similar in the two groups, while bile leak was 17.2% IG vs 5.6% no-IG (p=0.024). Median margin width was comparable in IG (1.4mm) and no-IG (2mm). Five years-Overall Survival(IG 45.9% vs no-IG 44.5%) and Disease-Free Survival (IG 35.9% vs no-IG 36.6%) were similar in the two groups.
Conclusion: IG has similar oncological outcomes of resected colorectal metastases without IG, although it affects surgical management.
‘United We Stand”: A Rare Case of Non-Incorporation of the Common Pulmonary Vein into Left Atrium
Authors: Chandrupatala Mrudula , Geetha S G 
Published: March 2023

Abstract
Purpose: Anatomic variations of left atrium that are commonly observed and reported are the occurrence of a common Right or Left pulmonary venous ostia though a solitary ostium for a common pulmonary vein on the left atrial wall in an adult cadaveric heart has hardly been reported before.
Method: A heart with a single ostium for PV was observed in the specimen collection of the gross anatomy lab. The organ was studied for identifying all external and internal features.
Results: A very rare case of a Solitary Pulmonary ostium on the posterior aspect of Left Atrium in an otherwise normal heart was observed.
Conclusion:This abnormal situation occurs when the solitary pulmonary vein which develops from an out-pouching of the primitive atrial chamber develops and its primary divisions fail to get incorporated into the left atrial wall as expected during development. Variant pulmonary veins have been reported as ectopic trigger spots for atrial fibrillation. This knowledge would benefit the radiologists and cardiovascular surgeons in this regard.
Identification, morphometry and volumetric analysis of the genial tubercles in radiographic and tomographic examinations
Authors: Oliveira Wallace , Melo Natalia , Silva Fernanda , Miranda Diogo A , Lima Izabella L A , Fernandino Lucas S , Manzi Flavio R 
Published: March 2023

Abstract
Purpose: To determine the identification, morphometry and volumetric analysis of genital tubercles in radiographic and tomographic examinations.
Methods: 15 dry human jaws were exposed to four stages. At first, they were exposed to two-dimensional radiographic and three-dimensional image examinations. In the second stage, the same image exams were performed on the mandibles with the genial tubers accentuated with barium sulphate. In the third stage, a gingival needle was inserted in the lingual foramen to perform the imaging exams. In the last stage, the genial tubercles were removed for imaging. The radiographs were evaluated by two radiologist dentists trained for morphological analysis. For the morphometric evaluation, the software ITK-snap® Version 3.6.0 was used.
Results: As a result of the periapical radiographs, no changes were observed in the initial or final images. In addition, with the highlight of barium sulphate, it is noticed that the genial tubers increase the radiopacity of the symphysis region. In the occlusal radiographic images, changes were observed in each of the stages, since the position of the mandible during the examination shows the projections of the genial tubercles, and the two-dimensional examination is indicated for the evaluation of these anatomical structures.
Conclusion: Cone beam computed tomography has, in a different way, the property of providing three-dimensional images rich in detail. Thus, it can be concluded that the periapical radiography of the lower incisors highlights the lingual canal, the occlusal radiography highlights the genial tubercles and tomography is the exam that presents the conditions to differentiate these structures.
Assessment on Heavy metals contamination of Ponnai River Sand in Tamil Nadu – A statistical approach using pollution indices
Authors: Kumar C. K. Senthil , Chandrasekaran A. , Gurumoorthy C. 
Published: March 2023

Abstract
Anthropogenic activities such as wastewater discharge by industries, mining, and electricity generation cause an increase in the concentration of some toxic heavy metals in the river environment. In addition, agricultural activities in the vicinity of the river environment may cause the enrichment of heavy metals. In the present study, heavy metal concentrations of Pb, As, Hg, Ni, Zn, Cu, Cr, and Mn along the Ponnai river, Tamil Nadu are considered to assess the role of industrial and agricultural activities. Emanating from the Paradarami hill ranges, the Ponnai River is seasonal and remains generally dry and sandy throughout the year, and does not contribute much to sustained irrigation. However, the river area has the benefit of receiving rainfall during both southwest and northeast monsoon periods. Statistical approach to assess the distribution of heavy metals by means of quantitative pollution parameters like the geo-accumulation index (Igeo), contamination factor (CF), and pollution load index (PLI) indicate the sand samples are not polluted by measured heavy metals and hence there is no influence of anthropogenic activities are in the study area. In this analysis, PLI accounted for 25.34% of the total variance and was positive with loadings of As, Cu, Zn, Cr, Ni, and Mn; PC2 accounted for 11.25% of the total variance and was significant loadings with Cu, Cr, and Ni. These results suggest that the heavy metals represented by PLI were predominantly derived from natural sources, except for As and Cr.
A Hybrid Arabic text summarization Approach based on Seq-to-seq and Transformer
Authors: Elsaid asmaa , mohamed ammar , Fattouh lamiaa , sakre mohamed 
Published: March 2023

Abstract
Text summarization is essential in natural language processing as the data volume increases quickly. Therefore, the user needs to summarize that data into a meaningful text in a short time. There are two common methods of text summarization: extractive and abstractive. There are many efforts to summarize Latin texts. However, summarizing Arabic texts is challenging for many reasons, including the language’s complexity, structure, and morphology. Also, there is a need for benchmark data sources and a gold standard Arabic evaluation metrics summary. Thus, the contribution of this paper is multi-fold: First, the paper proposes a hybrid approach consisting of a Modified Sequence-To-Sequence (MSTS) model and a transformer-based model. The seq-to-seq-based model is modified by adding multi-layer encoders and a one-layer decoder to its structure. The output of the MSTS model is the extractive summarization. To generate the abstractive summarization, the extractive summarization is manipulated by a transformer-based model. Second, it introduces a new Arabic benchmark dataset, called the HASD, which includes 43k articles with their extractive and abstractive summaries. Third, this work modifies the well-known extractive EASC benchmarks by adding to each text its abstractive summarization. Finally, this paper proposes a new measure called the Arabic-rouge measure for the abstractive summary depending on structure and similarity between words. The proposed method is tested using the proposed HASD and Modified EASC benchmarks and evaluated using Rouge, Bleu, and Arabic Rouge. The experimental results show satisfactory results compared to state-of-the-art methods.
Structural, Mechanical and Morphological Analysis of Treated Sisal Fibers and Cellulose Extracted from Sisal and it effect on Improving the Plaster-based Composites Mechanical Properties
Authors: Zidi Samir , miraoui Imed , Jaballi Sebti 
Published: March 2023

Abstract

In the context of attempts to protect the environment and the ongoing exhaustion of fossil resources, using biomass raises significant environmental concerns. From this approach, sisal fibers and the cellulose extracted from them are used as bio-reinforcement in the production of composite materials. The first part of this paper will examine the effects of sodium hydroxide treatment on the mechanical characteristics of natural sisal fibers. Then, the morphological properties of the surface of the fibers were determined using scanning electron microscopy (SEM). X-ray diffraction was performed on the treated and untreated fibers. The results showed that the cellulose and the treated fibers had a greater crystallinity index than the untreated fibers. The results of the FTIR spectroscopic examination were strongly congruent with the results of the XRD and SEM analyses. The ATG, which was performed on both natural sisal fibers, treated sisal fibers, and cellulose fibers, also showed that treatment of the fibers increased their thermal resistance and stability. According to research on composite materials made of plaster reinforced by fibers, increasing the sisal treated fibers content in plaster molasses to 1.25% led to a greater improvement in the mechanical and physical characteristics with a rise of 35% in resistance to bending. Additionally, when applying the cellulose fibers extracted from sisal as a reinforcement to the plaster-based composite material, we obtain an incensement in the resistance bending by 48%.
Gray Wolf Optimizer with Communication Strategy Based on DV-Hopfor Nodes Location ofWireless Sensor Networks
Authors: Yu Dan , Yuan Ting , Qing Haiyin , Xie Wenwu , Zhu Peng 
Published: March 2023

Abstract
Node localization has been one of the critical and significant research problems in wireless sensornetworks (WSN). The DV-Hop method determines the location of an unknown node based onthe anchor node location and the multi-hop forwarding principle, but the method falls far shortof satisfactory localization accuracy. Therefore, an improved Gray Wolf Optimizer (GWO) withcommunication strategy (IGWO-CS) is proposed in this paper. A convergence function based onthe sine function is proposed to eliminate the limitation of the convergence factor 𝑎 on the searchability of the GWO algorithm. A communication strategy based on Lévy flight is designed, which canimprove the efficiency of information interaction between wolves 𝛼, 𝛽 and 𝛿 while also improving thesearch accuracy and convergence speed. Extensive experimental results on 23 well-known benchmarkfunctions and unknown nodes location in WSN demonstrate the effectiveness of the proposed IGWO-CS method and also show sufficient competitiveness compared with other state-of-the-art algorithms,while the proposed IGWO-CS algorithm can achieve satisfactory performance in a short time.
Lactobacillus rhamnosus ameliorates the arsenic induced toxicity in the gut microbiome and embryonic development of zebrafish (Danio rerio)
Authors: Jain Abhishek , Jain Roshni , Jain Subodh 
Published: March 2023

Abstract
Arsenic contamination related human health is an ongoing global problem. Thus, extremely efficient bioremediation methods is need of the day. By incorporating specific probiotic species as dietary supplements, gut bioremediation may be possible, it is a simple, affordable, and effective method of purging the human body of arsenic pollutants. It has been established that probiotic strains play significant roles in various biological processes, including gut homeostasis, growth, and development. However, no study have been conducted on the relationship among arsenic toxicity, probiotics, parental gut microbiome and the ability to modulate maternal transcripts. In this study, the effects of arsenic trioxide and Lactobacillus rhamnosus (L. rhamnosus) supplement on fish and changes in the gut microbiome and embryonic development were assessed using qPCR in zebrafish exposed to 10 (low), 250 (medium) and 500(high) ppb arsenic trioxide for 2, 6 and 12 weeks. Our results show that arsenic toxicity induce significant changes in gut microbiome composition and embryonic development and probiotic L. rhamnosus cause ameliorative effects. Two predominant phyla of gut microbiome herein investigated- Firmicutes and Bacteroidetes proportions were significantly increased in arsenic exposed groups, while no significant changes observed in L. rhamnosus exposed groups as compared to control. Also, expression of key genes involved in defence against xenobiotic and embryo development- DVR1 and ABCC5, respectively decreased significantly in arsenic exposed groups and ameliorative effects observed in L. rhamnosus exposed groups. The results suggested that the L. rhamnosus supplement can overcome arsenic induced toxicity.
The critical points of entire fractions and B.Shapiro's 12th conjecture of entire functions
Authors: Ma Lande , Ma Zhaokun 
Published: March 2023

Abstract
For any real polynomial p(x) of even degree k. B. Shapiro propose the 12th conjecture saying that the sum of the number of real zeros of two polynomials ((k - 1)(p'(x))2 - kp(x)p''(x) and p(x)) is larger than 0. We comprehensively prove the original B.Shapiro's 12th conjecture and B.Shapiro's 12th conjecture of entire functions by showing all cases that the conjecture are true, and the case that it is not true.
Mathematics Subject Classification: Primary 30C15 Secondary 30D20, 26C10
Personalized brachytherapy for a Herlyn-Werner-Wunderlich syndrome patient with endometrial cancer: A case report
Authors: Zeng Zheng , Lu Yuanyuan , Zhang Fuquan , Zhang Jie , Zhang Wenjun , Luo Chunli , Guo Yuping , Yan Junfang , Yu Lang 
Published: March 2023

Abstract
Background: Endometrial carcinoma (EC) is a common gynecological malignancy. Vaginal cuff brachytherapy (VBT) is an adjuvant treatment ​for EC. Because a single-channel cylinder sometimes delivers inadequate dose coverage to the vaginal apex, three-dimensional (3D)-printing technology can be used to achieve satisfactory dose
distribution. Here, we report the first case of an EC patient with Herlyn-Werner-Wunderlich syndrome (HWWS) treated with VBT using 3D-printed applicators.
Case presentation: Here, we present a case study of endometrial cancer patient with Herlyn‑Werner‑Wunderlich syndrome who underwent surgery. During adjuvant radiotherapy, 3D-printed applicators were used in vaginal cuff brachytherapy. To accomplish the reconstruction of the source pathways on MRI, catheters with copper sulfate were placed in two 3D-printed applicators. The early tolerance of this treatment was positive. During the 6-month follow-up, locoregional recurrence was not detected.
Conclusions: Our findings strongly indicate that VBT with 3D-printed applicators may be a reasonable treatment option for EC with HWWS.
Physiological genetic identification of wild cornelian cherry genotypes in terms of phenolic compounds, organic acids and antioxidants
Authors: Taş Akgul , Gundogdu Muttalip 
Published: March 2023

Abstract
In this study, antioxidant, total monomeric anthocyanin (3-rutinoside), phenolic compounds, organic acids and vitamin C contents of fruits belonging to cornelian cherry genotypes were determined. Principal component and cluster analyzes were performed to determine the correlation between compounds. In the study, when the organic acid content of the fruits was examined, it was seen that tartaric acid and citric acid followed this acid with the highest malic acid content. It was determined that ellagic acid, catechin and chlorogenic acid, which are specific phenolics, are generally higher than other phenolic compounds. Total anthocyanin content showed great variation between genotypes and ranged from 3.79 µg cy-3-glu/g (14BL06) to 77.65 µg cy-3-glu/g. TEAC values were determined between 4.14 µmol TE/g − 11.03 µmol TE/g and FRAP values are between 3.37 µmol TE/g − 10.50 µmol TE/g. According to principal component analysis, the correlation between total antioxidant, total phenolic and total anthocyanins was 94.70%. While the correlation between phenolic compounds was determined as 42.40%, it was determined that the correlation between organic acids was 59%. As a result, it has been revealed that cornelian cherry gene sources are rich in biochemical contents and can be used effectively in functional foods.
NiZnFe2O4: An eco-compatible and magnetically separable catalyst for multicomponent synthesis of 2-amino-4H-chromenes
Authors: Patil Sandip P. , Shinde Sachinkumar K. , Desai Vikram M. , Pawar Arvind A. , Patil Suresh S. 
Published: March 2023

Abstract
The magnetically separable heterogeneous Nickel-Zinc ferrite (NiZnFe2O4) catalyst was synthesized and used for the first time as an environmentally friendly reusable catalyst for the synthesis of 2-amino-4H-chromene derivatives via a one-pot three-component condensation reaction of various salicylaldehydes and malononitrile or ethyl cyanoacetate with nitromethane or nitroethane in an ethanol at room temperature. There have been no reports of nickel zinc ferrite being used as a catalyst. The catalyst was specified by using several techniques, including DSC-TGA, FT-IR, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), BET, and scanning electron microscope (SEM). The present protocol suggests some benefits, which include green reaction conditions, simple reaction work-up, short reaction time, excellent product yields, chromatography-free purification, and high efficiency of the heterogeneous catalyst. More importantly, this catalyst was recovered from the reaction mixture using a simple external magnet, and it was reused successively at least seven times without any significant loss of catalytic activity.
Relative Timing Information and Orthology inEvolutionary Scenarios
Authors: Schaller David , Hartmann Tom , Lafond Manuel , Stadler Peter F. , Wieseke Nicolas , Hellmuth Marc 
Published: March 2023

Abstract
Background: Evolutionary scenarios describing the evolution of a family of genes within a collection of species comprise the mapping of the vertices of a gene tree T to vertices and edges of a species tree S. The relative timing of the last common ancestors of two extant genes (leaves of T) and the last common ancestors of the two species (leaves of S) in which they reside is indicative of horizontal gene transfers (HGT) and ancient duplications. Orthologous gene pairs, on the other hand, require that their last common ancestors coincides with a corresponding speciation event. The relative timing information of gene and species divergences is captured by three colored graphs that have the extant genes as vertices and the species in which the genes are found as vertex colors: the equal-divergence-time (EDT) graph, the later-divergence-time (LDT) graph and the prior-divergence-time (PDT) graph, which together form an edge partition of the complete graph.
Results: Here we give a complete characterization in terms of informative and forbidden triples that can be read off the three graphs and provide a polynomial time algorithm for constructing an evolutionary scenario that explains the graphs, provided such a scenario exists. While both LDT and PDT graphs are cographs, this is not true for the EDT graph in general. We show that every EDT graph is perfect. While the information about LDT and PDT graphs is necessary to recognize EDT graphs in polynomial-time for general scenarios, this extra information can be dropped in the HGT-free case. However, recognition of EDT graphs without knowledge of putative LDT and PDT graphs is NP-complete for general scenarios. In contrast, PDT graphs can be recognized in polynomial-time. We finally connect the EDT graph to the alternative definitions of orthology that have been proposed for scenarios with horizontal gene transfer. With one exception, the corresponding graphs are shown to be colored cographs.
Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias
Authors: Bentivenga Giuseppe Mario , Baiardi Simone , Mastrangelo Andrea , Zenesini Corrado , Mammana Angela , Polischi Barbara , Capellari Sabina , Parchi Piero 
Published: March 2023

Abstract
Background
The levels of synaptic markers synaptosomal-associated protein 25 (SNAP-25) and neurogranin (Ng) have been shown to increase early in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob disease (CJD) and to have prognostic potential. However, no validation studies assessed these biomarkers' diagnostic and prognostic value in a large clinical setting cohort of rapidly progressive dementia.
Methods
In this retrospective study, using commercially available immunoassays, we measured the levels of SNAP-25, Ng, 14-3-3, total-tau (t-tau), neurofilament light chain (NfL), and phospho-tau181 (p-tau) in CSF samples from consecutive patients with CJD (n = 220) or non-prion rapidly progressive dementia (np-RPD) (n = 213). We evaluated and compared the diagnostic accuracy of each CSF biomarker and biomarker combination by receiver operating characteristics curve (ROC) analyses, studied SNAP-25 and Ng CSF concentrations distribution across CJD subtypes, and estimated their association with survival using multivariate Cox regression analyses.
Results
CSF SNAP-25 and Ng levels were higher in CJD than in np-RPD (SNAP-25: 582, 95% CI 240–1250 vs. 115, 95% CI 78–157 pg/ml, p < 0.0001; Ng: 841, 95% CI 411–1473 vs. 390, 95% CI 260–766 pg/ml, p < 0.001). SNAP-25 diagnostic accuracy (AUC 0.902, 95% CI 0.873–0.931) exceeded that of 14-3-3 (AUC 0.853, 95% CI 0.816–0.889), t-tau (AUC 0.878, 95% CI 0.845–0.901), and the t-tau/p-tau ratio (AUC 0.884, 95% CI 0.851–0.916). In contrast, Ng performed worse (AUC 0.697, 95% CI 0.626–0.767) than all other surrogate biomarkers, except for NfL (AUC 0.649, 95% CI 0.593–0.705). SNAP-25 maintained a relatively high diagnostic value even for atypical CJD subtypes (AUC 0.792, 95% CI 0.729–0.854). In Cox regression analyses, SNAP-25 levels were significantly associated with survival in CJD (hazard ratio [HR] 1.71 95% CI 1.40–2.09). Conversely, Ng was associated with survival only in the most rapidly progressive CJD subtypes (sCJD MM(V)1 and gCJD M1) (HR 1.81 95% CI 1.21–2.93).
Conclusions
In the clinical setting, CSF SNAP-25 is a viable alternative to t-tau, 14-3-3, and the t-tau/p-tau ratio in discriminating the CJD subtypes from other RPDs. Additionally, both CSF SNAP-25 and Ng predict survival in CJD, with the former showing a higher prognostic value.