bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ameliorating Effect of Ashwagandha (Withania Somnifera) Extract on Hippocampus and Growth Plate Changes Associated With Propylthiouracil Induced Hypothyroidism in Juvenile Rats
Authors: Ibrahim Noha , Diab Marwa , Hassan Aliaa , Anwar Hend , Ragab Waleed , Morsi Enas , Diab Marwa , Boushra Amy , Sadek Nehad 
Published: April 2023

Background: Hypothyroidism is a decrease in the production of the thyroid hormones and leads to gland dysfunction. Ashwagandha extract was used as an ayurvedic treatment and supposed to be as antihypothyroidism agent.
Objectives: to investigate the impact of ashwagandha (Ash) extract on propylthiouracil (PTU)-induced hypothyroidism in rats.
Subjects and Methods: The rats were divided into three groups, control group, PTU (hypothyroid) group (6mg/kg/day by oral route), PTU (6mg/kg/day by oral route) +Ash (50mg/kg/day by oral route) treated group. All treatment continued for 30 days. At the end of experiment, measurement of serum T3, T4 and TSH was performed. Thyroid gland, right sided tibia and dentate gyrus region of hippocampus were examined using histological, histochemical and immunohistochemical studies. All measurements were statistically analyzed.
Results: Decrease in serum T3 and T4 and congestion of the blood capillaries, follicular distortion, and vacuolar degeneration of some follicular cells were exhibited in thyroid gland of hypothyroid group. Histological changes in growth plate cartilage in the form of decrease of matrix deposition and plate thickness were detected. Dentate gyrus showed distorted granule cell layer. Immunohistochemically, low expression of the GFAP was expressed in astrocytes. PTU+Ash treated group showed improvement of the previous changes.
Conclusion: Administration of ashwagandha with PTU displayed protective effect on the thyroid gland and its associated histological changes in growth plate cartilage and dentate gyrus. Higher doses of ashwagandha should be used for extrapolation if it may give better results than the used dose.
Empirical Evaluation of Financial Performance Differentials between Quoted and Unquoted Firms in Nigeria: Asset Base and Revenue as critical Determinants
Authors: Osirim Monday , Wadike Chile George 
Published: April 2023

There has been a long debate on what constitutes the financial performance of a firm. The thrust of this paper therefore was to determine the financial performance of quoted and unquoted firms in Nigeria using asset base and revenue as critical determinants. The study is hinged on the philosophy and perception that quoted firms performs better than unquoted firms. A sample of Eighteen (18) firms was selected, nine apiece for quoted and unquoted companies. The analysis of the firms covered a period of nine years from 2008 to 2017. Vital information from the selected firms’ audited financial reports for various years were collected and analyzed. A Panel data fixed effect was used to determine the financial performance of quoted and unquoted firms while a paired sample statistics test was used in comparing the mean difference of both firms. Empirical results indicate that asset base and revenue have positive impact on the financial performance of quoted firms while only revenue has a positive relationship with financial performance of unquoted firms. The study concludes that there is a difference in the financial performance of quoted and unquoted firms in Nigeria. This difference may have emanated from the fact that unquoted companies lack the financial muscle that could be garnered by quoted firms; thus necessitating the recommendations that the Nigerian Stock Exchange should review its listing requirements to accommodate unquoted companies intending to be quoted.
Agricultural Financing - Agricultural Sector Output Nexus: A Case Study of The Nigerian Economy
Authors: Helen Falaye Motunrayo 
Published: April 2023

The study “Agricultural Financing -Agricultural sector output nexus: in Nigeria” investigated the effect of agricultural financing, both public and private on the outputs of two main sectors of agriculture: crop production and livestock production. Three objectives were formulated to provide guide to this study: examine the long and short run relationship of agricultural financing on crop production output and livestock production output, and to examine the causal relationship between agricultural financing and agricultural sector output. To achieve these objectives, the study employed two models, each using ARDL Test, Bounds Test, and Granger causality test using time series data from 1981 to 2019.Data was obtained from CBN and World Bank data base. Dependent variables were Crop Production output and Livestock Production output respectively and independent variables were Public Finance, Commercial Bank Credit to Agriculture, Inflation Rate and Interest Rate. The model was tested using descriptive statistics to analyse the significance of the relationship between the dependent and independent variables. The results show that both public and private finance were positive but insignificant in the short run. In the long run, public finance remained insignificant whereas private finance was positive and significant. Thus, private financing is more effective at improving agricultural output than public finance. The study also revealed a negative long run relationship between interest rate and the outputs of crop and livestock production during the period. It is therefore recommended that the government encourages private investment in agricultural activity, and puts measures in place to curb corruption and embezzlement. Government should also ensure that credit facilities are provided to farmers at low interest rate to reduce detrimental influences.
Using Mitral Annular Plane Systolic Excursion (MAPSE) and Tissue Doppler Imaging Systolic Velocity (TDIS’) As Surrogates of Left Ventricular Systolic Function
Authors: Aiwuyo Henry Osarume , Osarenkhoe Osaretin John , Umuerri Ejiroghene Martha , Aigbe Fredrick I , Onuwaje Okoke Eseoghene , Atoe-Imagbe Osagioduwa Mike , Obasohan Austine O 
Published: April 2023

Purpose: Echocardiography has become a useful method for assessing structural diseases of the heart. MAPSE and TDI S’ have also been shown to be reproducible assessments of longitudinal heart changes as LVEF is ineffective in cases of sub-optimal echocardiographic imagery caused by artefacts or air trapping.
Methodology: One hundred patients referred for echocardiography at the cardiac laboratory of DELSUTH, Oghara, Nigeria was recruited for the study. All patients had trans-thoracic echocardiography done with M-Mode, 2D and Spectral Doppler and Tissue Doppler echocardiographic images acquired. Data obtained was analyzed using IBM-SPSS version 22. A p-value of ≤0.05 was considered significant for all comparisons.
Findings: Hypertension was the commonest indication for an echocardiogram. The prevalence of abnormal left ventricular function was 13%, 24% and 28% as determined using LVEF, TDI S’ and MAPSE. MAPSE had a higher specificity than TDI S’ with statistically significant correlations found between TDI S’ (p<0.001); MAPSE (p=0.032) and LVEF. Multiple linear and binomial logistic regression analysis showed significant relationships (beta=0.423; p <0.001) and odd ratios [OR(CI) = 10.80(2.56- 49.07)] respectively between TDI S’ and LVEF.
Unique Contribution to Theory, Policy and Practice: MAPSE’s specificity allows for diagnosis of longitudinal heart functional changes even in cases where the LVEF may be within normal limits. A combination of both MAPSE and TDI S’ offer a greater prognostic significance. The correlation between MAPSE and TDI S’ were good. Thus, MAPSE and TDI S’ can serve as surrogates for LVEF in assessing left ventricular systolic function and prognosticating cardiac disease
MOLECULAR DIAGNOSTIC LABORATORY SETUP AND MAINTENANCE FOR SARS-COV-2
Authors: GÜRER GİRAY Burcu , GÜVEN AÇIK Gökçe , BULUT Yunus Emre , ŞİMŞEK Asiye Çiğdem , KOTANOĞLU Mustafa Sırrı 
Published: April 2023

Abstract
Aim: Importance of laboratory diagnosis has come to the spotlight once again with the Covid-19 pandemic caused by Sars-CoV-2 and significant changes have taken place in terms of laboratory operation. A global effort has emerged when all healthcare professionals faced a biological threat. Interlaboratory collaboration and multidisciplinary approach contributed to this effort. This study aims to explain step-by-step establishment of a fully capable laboratory for Sars-CoV-2 diagnosis to support local and global fight for the COVID-19 pandemic.
Methods: Several precautions were taken, and disaster plans were updated because of the changes in employee health and workload distribution. Some of these are setting up a laboratory from scratch for microorganism diagnostic tests performed in pandemic cases, measures for healthcare workers, personnel assignment planning, changes in the variety and number of tests, innovations in quality standards and the contribution of laboratories to scientific studies.
Results: XXXXX Molecular Diagnostic Laboratory has become one of the laboratories in Türkiye where Sars-Cov-2 and its mutations have been studied the most with 1,710,856 samples between 01 October 2020 and 01 May 2022 since its establishment and it has become the laboratory with the highest number of equipment and technical personnel in the capital.
Conclusion: This study summarizes all the phases of XXXXX Molecular Diagnostic Laboratory beginning with its establishment from the scratch and covers all the steps to render this facility fully operational.

Keywords: COVID-19, laboratory disaster planning, laboratory staff, personal protective equipment, Sars-CoV-2
HIPERPLASIA VAGINAL EM CADELA: RELATO DE CASO
Authors: Ferreira Gislene Fernanda Oliveira , Davidsohn Alexia Franscoviaki , Jaines Vanessa Ingrid 
Published: April 2023

A puberdade é definida pela maturidade sexual, onde ocorre a liberação de hormônios da reprodução para que as fêmeas estejam aptas a gerar um novo ser. Infortunamente, algumas patologias reprodutivas podem surgir por meio de disfunções no funcionamento do sistema reprodutor, principalmente em cadelas fêmeas. Essas condições são de suma importância para a rotina clínica médica veterinária, o diagnóstico e prevenção de tais doenças devem ser certeiros para manter o bem-estar e saúde destes animais durante seu período de vida. Visto isso, o presente trabalho relata um episódio de hiperplasia vaginal grau III em uma cadela sem raça definida de um ano e três meses, na qual o tutor observou uma massa edemaciada de coloração normocorada se protruindo da vulva. O diagnóstico foi realizado através da anamnese sendo o tratamento recomendado ovário-histerectomia (OH), após o procedimento, a paciente apresentou total recuperação do quadro clínico.
O ESTÁGIO DOCENTE NO ENSINO SUPERIOR E OS MOVIMENTOS DE CONSTITUIÇÃO PROFISSIONAL: TESSITURAS DE UMA EXPERIÊNCIA
Authors: Silva Naiara Bamberg da , Silva Américo Junior Nunes da 
Published: April 2023

Este artigo tem por objetivo relatar as experiências oriundas de um Estágio Docente, realizado no Ensino Superior e obrigatório para os estudantes do Programa de Pós-Graduação em Educação, Cultura e Territórios Semiáridos (PPGESA) da Universidade do Estado da Bahia (Uneb), Campus III, Juazeiro – BA; refletindo acerca desse momento para o desenvolvimento profissional de uma professora experiente, que já atua na Educação Básica. O referido estágio foi realizado no componente curricular de Alfabetização na Educação de Jovens e Adultos (EJA), em uma turma do Curso de Licenciatura em Pedagogia da mesma instituição. As vivências oportunizadas proporcionaram problematizar sobre o papel do professor no ensino superior, em um curso de licenciatura, e o compromisso inerente à docência, sobretudo, da responsabilidade assumida com a formação de futuros professores, nesse caso alfabetizadores e atuantes na Educação de Jovens e Adultos, e o entendimento do papel do tirocinante como formador. Foi possível perceber, também, a relevância das atividades desenvolvidas e o amadurecimento que o contato com esse espaço do tirocínio e com os demais tirocinantes, a partir dos momentos de diálogo estabelecido, teve para a formação dos estudantes da licenciatura e para o desenvolvimento profissional do formador de professores.
Aligning Pancasila Values in The Regulation For Worship House Construction in Indonesia
Authors: Kiftiyah Anifatul , Sutrisno Tri 
Published: April 2023

Indonesia regulates the establishment of places of worship because its people adhere to different religions and beliefs, so it greatly influences the construction of the establishment of places of worship. The regulations for the construction of places of worship written in the Peraturan Bersama Menteri Agama dan Menteri Dalam Negeri (PBM) Nomor 9 and 8 Tahun 2006 are considered policies that discriminate against minorities. This research is a normative research with a juridical approach that uses the library research method to obtain valid sources as written references. The purpose of this research is that the regulations for the establishment of places of worship can be reviewed by synergizing Pancasila values ​​in them to avoid religious conflicts and for the sake of creating religious harmony. The conclusion of this study is that there are many cases of the construction of places of worship due to conditions that are considered discriminatory by minorities. So that this regulation needs to be reviewed by aligning the indicators of Pancasila values ​​based on the Badan Pembinaan Ideologi Pancasila Nomor 4 Tahun 2022 concerning Pancasila Indicators. Upholding Pancasila as grundnorm and staatfundamentalnorm means that all laws and policies must refer to Pancasila.
Problematik Konstitusionalitas Naturalisasi di Indonesia
Authors: Bimasakti Muhammad Adiguna 
Published: April 2023

Pewarganegaraan (naturalisasi) adalah proses pemberian kewarganegaraan bagi seorang warga negara asing. Pasal 26 ayat (1) Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 (UUD NRI Tahun 1945) mengamanatkan bahwa pengesahan kewarganegaraan bagi bangsa asing yang menjadi warga negara Indonesia ditetapkan dengan undang-undang. Sedangkan ketentuan dalam Pasal 13 ayat (1) Undang-Undang Nomor 12 Tahun 2006 Tentang Kewarganegaraan Republik Indonesia mengatur bahwa pemberian kewarganegaraan atau pewarganegaraan diberikan dengan keputusan presiden. Kedua norma ini tentu bertentangan satu sama lain. Pertanyaannya dalam rumusan masalah yang diangkat dalam tulisan ini adalah bagaimana pengaturan pewarganegaraan menurut Pasal 26 ayat (1) UUD NRI Tahun 1945 dan apakah pengaturan mengenai pemberian pewarganegaraan dengan keputusan presiden dalam Pasal 13 Undang-Undang Nomor 12 Tahun 2006 Tentang Kewarganegaraan Republik Indonesia konstitusional atau tidak. Penulisan artikel ini menggunakan metode yuridis normatif yakni penelitian hukum yang menggunakan bahan hukum primer dan sekunder yang terdiri dari peraturan perundang-undangan seputar topik mengenai pewarganegaraan, dan juga literatur terkait pewarganegaraan baik dari buku, artikel jurnal mau pun tulisan ilmiah lain yang relevan. Tulisan ini menemukan bahwa Pasal 26 ayat (1) UUD NRI Tahun 1945 mengatur pengesahan pewarganegaraan harus ditetapkan dengan undang-undang. Maksudnya bukan berarti pengesahan pewarganegaraan diatur dengan undang-undang tetapi benar-benar harus disahkan dengan suatu undang-undang tentang pengesahan pewarganegaraan dari pemohon pewarganegaraan. Kemudian tulisan ini juga menemukan bahwa pengaturan dalam Pasal 13 ayat (1) UU Kewarganegaraan yang mengatur bahwa pewarganegaraan diberikan dengan keputusan presiden adalah bertentangan dengan Pasal 26 ayat (1) UUD NRI Tahun 1945 atau dengan kata lain inkonstitusional sehingga harus diubah.
The Relationship Between HbA1c and 25-hidroxy Vitamin D Levels in Adult Diabetic Patients
Authors: ÖZDİN Mehmet , MUNDAN Durhasan 
Published: April 2023

Objective: The aim of this study was to determine vitamin D levels in patients with type II Diabetes Mellitus who applied to the internal medicine diabetes and endocrinology policlinic of a training and research hospital, and to determine the relationship between HbA1c and 25-hydroxy vitamin D levels.
Material and Method: Type II Diabetes Mellitus patients constituted the material of the study. The study was conducted between 2018-2019. The data were obtained from the hospital information management system. Those with bone-derived malignancies and pregnant women were excluded from the study. A total of 65 patients, 40 (61%) female and 25 (39%) males were included in the study. Statistical analyzes were made with the help of IBM SPSS for Windows 26.0 package program. The normal distribution was tested for the categories of factors affecting vitamin D levels. Accordingly, the hypothesis test was chosen and the descriptive statistics values suitable for the used hypothesis test were calculated. Variables indicated by measurement mean ± SD, smallest and largest; Variables that are represented by numbers are indicated by %. Pearson correlation coefficients were used to evaluate the correlations.
Results: HbA1c and 25-hydroxy vitamin D levels were determined in the patients included in the study. HbA1C levels were found to be 9,023 ± 1.72 (%) higher than the normal values. 25-hydroxy vitamin D levels were 13.94±4.12 ng/ml and were lower than normal values. HbA1c levels and 25-hydroxy vitamin D levels were found to be statistically significant in type II Diabetes Mellitus patients (p
ANALISIS PERHITUNGAN PENYUSUTAN AKTIVA TETAP MENURUT STANDAR AKUNTANSI KEUANGAN
Authors: Yuli Dianto Alfin , Winarko Puji 
Published: April 2023

Aktiva tetap merupakan salah satu sarana pendukung kegiatan operasional perusahaan. Namun seiring dengan pemakaiannya, suatu aktiva akan mengalami penyusutan. Penyusutan aktiva tetap akan menimbulkan biaya penyusutan yang dibebankan ke dalam laporan laba rugi setiap periode akuntansi.
Pada penelitian ini penulis menganalisis perhitungan penyusutan aktiva tetap menurut standar akuntansi keuangan serta undang-undang perpajakan terhadap penghasilan kena pajak pada perum pegadaian pusat.
Metode penelitian yang digunakan penulis adalah deskriptif kualitatif. Sedangkan jenis data yang digunakan adalah data Kualitatif dan data Kuantitatif. Berdasarkan penelitian ini menunjukkan Aktiva tetap Perum Pegadaian Pusat sudah dikelompokkan sesuai dengan jenis dan masa manfaat yang diharapkannya. Kebijakan perhitungan penyusutan untuk seluruh aktiva tetap Perum Pegadaian Pusat berdasarkan ketentuan perundang – undangan perpajakan pasal 11 Undang- undang No 17 Tahun 2000 tentang Pajak Penghasilan, untuk aktiva tetap kelompok bangunan disusutkan dengan metode garis lurus (Straight Line Method), sedangkan untuk kelompok bukan bangunan menggunakan saldo menurun ganda (Double Declining Method). Dan laba kena pajak komersial Perum Pegadaian Pusat per 31desember 2006 mengalami perbedaan.
İç Anadolu’da İklim Değişikliği Sürecinde Rüzgâr Erozyonu ve Rüzgâr Perdeleri Üzerine Değerlendirmeler ve Öneriler
Authors: YAVUZ Özlem 
Published: April 2023

İç Anadolu kuzey ve güneyinde dağlık arazi arasında bulunmakta olup, deniz etkisine kapalı bölgemizdir. İç Anadolu Bölgesi’nde yağışlar çok az (300-350 mm/yıl) olup, yazları sıcak ve kurak, kışları soğuk ve kurak olan tipik bir “Bozkır İklimi” etkilidir. Tarih boyunca Hitit’lerden beri yoğun bir alanı olan İç Anadolu’da nüfus yoğunluğu arttıkça orman tahribi de yaygınlaşmıştır. Kurak bölge ormanları kesilmiş, otlaklarda ve ormanlarda aşırı otlatmalar bitki örtüsünü yok edecek ölçüde tahribine sebep olmuştur. Bölgede esen kuru ve kurutucu rüzgârların etkisi ile bitki örtüsü yok edilmiş ve korumasız kalmış olan toprakların ince bölümü (Kil ve toz) taşınmıştır. Geriye kalan kum bölümü ile tarım, otlak ve orman alanları giderek kara kumulları ile kaplanmıştır. Kara kumullarına karşı 1962 yılında Karapınar’da başlatılan “Kumul önleme çalışmaları” ve iki Devlet Üretme çiftliğinde yetiştirilen “Rüzgâr Perdeleri” başarılı örnek ağaçlandırmalardır. Bu ağaçlandırmalar bazı köy çevrelerinde de koruyucu ormanların kurulmasına örnek olmuştur. Alçak arazide yapılan bu çalışmaların yanında, dağlık arazide de başarılı ağaçlandırmalar yapılmıştır. Böylece dağlık araziye düşen yağışların toprağa sızdırılması sağlanmıştır.
Ancak küresel iklim değişimi İç Anadolu’da “Isınma/kuraklaşma” süreci olarak etkisini göstermektedir. Ortalama sıcaklık değerlerinde belirgin bir artış vardır. Yıllık toplam yağışlar ise zaten çok az olduğu ve de pek az arttığı için yetersizdir. Artan kuraklık ve daha kuru esen rüzgârlar İç Anadolu Bölgesi’nde alçak arazideki otlaklarda rüzgâr perdelerinin kurulmasını, tahrip edilmiş, seyrek çalılıklara dönüştürülmüş orman alanlarının hızla ağaçlandırılmasını ve de tarım alanlarında koruyucu ağaç ve çalı perdelerinin yetiştirilmesini gerektirmektedir.
Langkah-langkah Manajemen Strategik di Lembaga Pendidikan Islam
Authors: Kautsar Muhammad , Julaiha Siti 
Published: April 2023

Manajemen strategik adalah proses dari tiga kegiatan: pengembangan strategi, pelaksanaan strategi, dan evaluasi strategi. Pada dasarnya manajemen strategik lebih kepada pengembangan sebuah bisnis atau organisasi. Keputusan perencanaan strategik mengikat pada perusahaan atau organisasi dengan produk, pasar, sumber daya, dan teknologi tertentu dari waktu ke waktu. Strategik sendiri menciptakan keunggulan kompetitif jangka panjang. Apapun yang terjadi, keputusan strategik memiliki dampak fungsional dan jangka panjang yang signifikan pada sebuah lembaga pendidikan islam. Menerapkan strategi mengharuskan sebuah lembaga Pendidikan untuk menetapkan tujuan tahunan, memberikan pedoman, memotivasi guru dan karyawan, dan mengalokasikan sumber daya sehingga strategik yang dirumuskan dapat diimplementasikan. Eksekusi strategi adalah mobilisasi guru, karyawan dan kepala madrasah selaku manajer untuk menerapkan strategi yang telah dirumuskan ke dalam tindakan. Evaluasi strategi adalah tahapan terakhir dari manajemen strategik. Proses manajemen strategik terdiri dari tiga tahap atau langkah. Adapun tahap atau langkah tersebut adalah: Perumusan strategi, Pelaksanaan Strategi, dan Evaluasi strategi.
PENGARUH BRAND IMAGE DAN BRAND TRUST TERHADAP PURCHASE BEHAVIOR PADA GENERASI Y DAN Z DENGAN COSTUMER LOYALITY SEBAGAI VARIABEL INTREVENING PADA GENERASI Y DAN Z (STUDI KASUS TOKO AZZAM COLLECTION)
Authors: Ristanti Aquarini  , Sumitro  , Aulia Indra  
Published: April 2023

Penelitian ini bertujuan untuk meneliti Pengaruh Brand Image Dan Brand Trust Terhadap Purchase Behavior Pada Generasi Y Dan Z Dengan Costumer Loyality Sebagai Variabel Intrevening Pada Generasi Y Dan Z. Pengumpulan data dilakukan dengan penyebaran kuesioner dan disebar kepada 100 sampel penelitian. Analisis data pada penelitian ini menggunakan bantuan SPSS versi 20. Teknik pengujian data yang dilakukan pada penelitian ini meliputi uji validitas dan reabilitas, Uji asumsi klasik, analisis regresi linier berganda, dan Pengujian secara parsial dan simultan. Hasil analisis menunjukkan bahwa brand image berpengaruh positif dan signifikan terhadap purchase behavior hal ini telihat dari hasil pengujian t tabel yang menunjukkan bahwa 6,737<1,984 (t hitung>t tabel), brand trust berpengaruh positif dan signifikan terhadap purchase behavior hal ini telihat dari hasil pengujian t tabel yang menunjukkan bahwa 2,814<1,984 (t hitung>t tabel), brand image berpengaruh positif dan signifikan terhadap costumers loyality hal ini telihat dari hasil pengujian t tabel yang menunjukkan bahwa 2,892<1,984 (t hitung>t tabel), brand trust berpengaruh positif dan signifikan terhadap custumers loyality hal ini telihat dari hasil pengujian t tabel yang menunjukkan bahwa 3,038<1,984 (t hitung>t tabel). Hal penelitian diketahui dari pengujian secara parsial yang menunjukkan bahwa variabel independent memberikan pengaruh terhadap variabel independen dan intrevening.