bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environment‐Responsive Peptide Dimers Bind and Stabilize Double‐Stranded RNA
Authors: McLoughlin Niall M. , Albers Marvin A. , Collado Camps Estel , Paulus Jannik , Ran Youri A. , Neubacher Saskia , Hennig Sven , Brock Roland , Grossmann Tom N. 
Published: August 2023

AbstractDouble‐stranded RNAs (dsRNA) possess immense potential for biomedical applications. However, their therapeutic utility is limited by low stability and poor cellular uptake. Different strategies have been explored to enhance the stability of dsRNA, including the incorporation of modified nucleotides, and the use of diverse carrier systems. Nevertheless, these have not resulted in a broadly applicable approach thereby preventing the wide‐spread application of dsRNA for therapeutic purposes. Herein, we report the design of dimeric stapled peptides based on the RNA‐binding protein TAV2b. These dimers are obtained via disulfide formation and mimic the natural TAV2b assembly. They bind and stabilize dsRNA in the presence of serum, protecting it from degradation. In addition, peptide binding also promotes cellular uptake of dsRNA. Importantly, peptide dimers monomerize under reducing conditions which results in a loss of RNA binding. These findings highlight the potential of peptide‐based RNA binders for the stabilization and protection of dsRNA, representing an appealing strategy towards the environment‐triggered release of RNA. This can broaden the applicability of dsRNA, such as short interfering RNAs (siRNA), for therapeutic applications.
Catalytic Synthesis of β‐(Hetero)arylethylamines: Modern Strategies and Advances
Authors: Pozhydaiev Valentyn , Muller Cyprien , Moran Joseph , Lebœuf David 
Published: August 2023

Abstractβ‐(Hetero)arylethylamines appear in a myriad of pharmaceuticals due to their broad spectrum of biological properties, making them prime candidates for drug discovery. Conventional methods for their preparation often require engineered substrates that limit the flexibility of the synthetic routes and the diversity of compounds that can be accessed. Consequently, methods that provide rapid and versatile access to those scaffolds remain limited. To overcome these challenges, synthetic chemists have designed innovative and modular strategies to access the β‐(hetero)arylethylamine motif, paving the way for their more extensive use in future pharmaceuticals. This review outlines recent progresses in the synthesis of (hetero)arylethylamines and emphasizes how these innovations have enabled new levels of molecular complexity, selectivity, and practicality.
Asymmetric Allenylation of Alkynes mediated by Chiral Organoselenated Reagents under Oxidative Conditions
Authors: Sun Rongyu , Viaud Emilie , Nomula Rajesh , Naubron Jean‐Valère , Daugey Nicolas , Buffeteau Thierry , Castet Frédéric , Toullec Patrick Y. , Quideau Stéphane , Peixoto Philippe A. 
Published: August 2023

AbstractThe reactivity of novel chiral lactamide‐substituted diselenide‐based reagents under oxidative conditions was exploited to develop a metal‐free method for the preparation of enantioenriched allenylamides from simple alkynes in good yields, and with enantiomeric excesses up to 99 %. The key of the success in this method is attributed to the hydrogen‐bonded lactamide appendages that ensure configurational stability of chiral vinyl selenoxide intermediates for an optimal enantiotopic β‐syn‐elimination step.
Molecular simulation on the mechanical and thermal properties of modified insulating paper cellulose doped with trapezoidal polyphenylsesquisiloxane at different temperature
Authors: Zeng Zhenglin , Su Ziming , Wang Shumin , Wang Zuhao , Tang Chao 
Published: August 2023

AbstractWith the further development of the transmission and distribution network, the requirements for the insulating system of power equipment are further deepened. As one of the important factors, insulating paper is of great value to improve its performance. The pure cellulose model and trapezoidal polyphenylsesquisiloxane (T‐PPSQ) composite model are established to analyze the mechanical and thermal properties of insulating paper cellulose. The effects of T‐PPSQ doping at different temperature on properties of cellulose are investigated by comparing the radial distribution function, mechanical parameters, glass transition temperature, mean square displacement (MSD), and free volume fraction (FVF) through molecular dynamics method. The results show that T‐PPSQ can improve the ability of cellulose to resist shear stress at different temperatures, showing good mechanical properties. When the temperature is 423 K, the mechanical performance parameters elastic modulus, bulk modulus and shear modulus can be increased by 47.2%, 18.2%, and 38.56% at most. The glass transition temperature of the insulating paper cellulose with T‐PPSQ increases by 64 K, the MSD and the FVF all decrease at different temperature which demonstrated it has improved thermal stability. The research in this paper is of great significance for improving the life of the insulating system of power equipment.
Ecological risk assessment in the southern Indian Ocean: Towards better seabird bycatch mitigation
Authors: Reid Keith , Baker G. Barry , Delord Karine 
Published: August 2023

Abstract

Fisheries bycatch has been identified as the most serious threat to many seabird species and there is an increasing awareness of the responsibility of fisheries management bodies to include the impact on non‐target species in their management and regulatory frameworks.
In 2022, an ecological risk assessment (ERA) for seabirds and fisheries was presented to the Scientific Committee of the Southern Indian Ocean Fisheries Agreement (SIOFA). This ERA identified 32 seabird species that regularly occurred in the SIOFA Area, of which 11 were determined as being at high risk. This high‐risk group included 10 albatross species that have the greatest likelihood of interacting with SIOFA managed fisheries in Subareas 1, 2 and 3b (west of 40° E) where they overlap with the pelagic longline fishery.
Although the pelagic longline fishery for Ruvettus pretiosus is the largest fishery under the auspices of SIOFA, in terms of catch and number of vessels, the existing management measures of SIOFA focused on demersal fisheries and did not include any mitigation requirements for pelagic longlines. In response to the outcomes of the ERA, a proposed amendment to SIOFA's management measures was presented by France to the Meeting of Parties of SIOFA and led to the revision of SIOFA's seabird bycatch mitigation measures in respect of pelagic longlines, making them consistent with those agreed by the Indian Ocean Tuna Commission.
Regulatory diffusion, the increased likelihood of adoption of regulation by one agency if that regulation has been adopted by another agency, contributed to the relatively rapid transition from the identification of the risk posed by pelagic longline vessels to the change in regulations to address those risks in SIOFA.
Biological evaluation of [4‐(4‐aminophenyl)‐1‐(4‐fluorophenyl)‐1H‐pyrrol‐3‐yl](3,4,5‐trimethoxyphenyl)methanone as potential antineoplastic agent in 2D and 3D breast cancer models
Authors: Mazzoccoli Carmela , Crispo Fabiana , Laurenzana Ilaria , Pietrafesa Michele , Sisinni Lorenza , Lerose Rosa , Telesca Donatella , Milella Maria R. , Liu Te , Della Sala Gerardo , Sebastiani Jessica , Silvestri Romano , La Regina Giuseppe 
Published: August 2023

AbstractTargeting tubulin polymerization and depolymerization represents a promising approach to treat solid tumors. In this study, we investigated the molecular mechanisms underlying the anticancer effects of a structurally novel tubulin inhibitor, [4‐(4‐aminophenyl)‐1‐(4‐fluorophenyl)‐1H‐pyrrol‐3‐yl](3,4,5‐trimethoxyphenyl)methanone (ARDAP), in two‐ and three‐dimensional MCF‐7 breast cancer models. At sub‐cytotoxic concentrations, ARDAP showed a marked decrease in cell proliferation, colony formation, and ATP intracellular content in MCF‐7 cells, by acting through a cytostatic mechanism. Additionally, drug exposure caused blockage of the epithelial‐to‐mesenchymal transition (EMT). In 3D cell culture, ARDAP negatively affected tumor spheroid growth, with inhibition of spheroid formation and reduction of ATP concentration levels. Notably, ARDAP exposure promoted the differentiation of MCF‐7 cells by inducing: (i) expression decrease of Oct4 and Sox2 stemness markers, both in 2D and 3D models, and (ii) downregulation of the stem cell surface marker CD133 in 2D cell cultures. Interestingly, treated MCF7 cells displayed a major sensitivity to cytotoxic effects of the conventional chemotherapeutic drug doxorubicin. In addition, although exhibiting growth inhibitory effects against breast cancer cells, ARDAP showed insignificant harm to MCF10A healthy cells. Collectively, our results highlight the potential of ARDAP to emerge as a new chemotherapeutic agent or adjuvant compound in chemotherapeutic treatments.
Beyond Molecular Recognition: A Perylene Bisimide Derivative as a Functional Mimic of Chlorpyrifos
Authors: Devi Minakshi , Sharma Pooja , Sharma Neha , Kaur Satwinderjeet , Devi Meena , Kaur Sanehdeep , Sharma Kavita , Raghav Neera , Singh Lovedeep , Bhatti Rajbir , Kumar Manoj , Bhalla Vandana 
Published: August 2023

AbstractSupramolecular assemblies of perylene bisimide derivative (PBI‐SAH) have been developed which show ‘turn‐on’ detection of chlorpyrifos in aqueous media, apple residue and blood serum. Differently from the already reported fluorescent probes for the detection of CPF, PBI‐SAH assemblies also show affinity for acetylcholinesterase (AChE) which endow the PBI‐SAH molecules with mixed inhibitory potential to restrict the AChE catalysed hydrolysis of acetylthiocholine (ATCh) in MG‐63 cell lines (in vitro) and in mice (in vivo). The molecular docking studies support the inhibitory activity of PBI‐SAH assemblies and their potential to act as safe insecticide with high benefit to harm ratio. The insecticidal potential of PBI‐SAH derivative has been examined against Spodoptera litura (S. litura) and these studies demonstrate its excellent insecticidal activity (100 % mortality in nineteen days). To the best of our knowledge, this is the first report regarding development of PBI‐SAH assemblies which not only detect chlorpyrifos but also mimic AChE inhibitory activity of CPF to show promising aptitude as safe insecticide.
A PSCLC Pattern Prepared Based on Handedness Inversion for Anti‐counterfeiting
Authors: Zhao Jinghua , Yu Runwei , Wu Limin , Li Yi , Liu Wei , Yang Yonggang 
Published: August 2023

AbstractHandedness inversion has been widely studied in supramolecular chemistry and material sciences. Herein, a photoisomerizable chiral dopant was synthesized, which could induce the formation of a cholesteric phase with right‐handedness. The Bragg reflection band of the cholesteric liquid crystal (CLC) mixture shifted to the long wavelength with extending 365 nm UV light irradiation time. Based on this photochromic property, a colourful polymer‐stabilized CLC (PSCLC) film was prepared using a grayscale mask. A handedness reversible CLC mixture was prepared using a mixture of this chiral dopant and S5011. With extending the UV light irradiation time, the handedness of the CLC mixture changed from right‐ to left‐handedness. A patterned PSCLC film was prepared using this CLC mixture. Complementary images were observed under right‐ and left‐handedness circularly polarized lights. The results shown here not only give us a better understanding the competition between photopolymerization and photoisomerization, but also lay the foundations for decoration and anti‐counterfeiting.
The application of electrosprayed minocycline‐loaded PLGA microparticles for the treatment of glioblastoma
Authors: Arriaga Marco A. , Amieva Juan A. , Quintanilla Jaqueline , Jimenez Angela , Ledezma Julio , Lopez Silverio , Martirosyan Karen S. , Chew Sue Anne 
Published: August 2023

AbstractThe survival of patients with glioblastoma multiforme (GBM), the most common and invasive form of malignant brain tumors, remains poor despite advances in current treatment methods including surgery, radiotherapy, and chemotherapy. Minocycline is a semi‐synthetic tetracycline derivative that has been widely used as an antibiotic and more recently, it has been utilized as an antiangiogenic factor to inhibit tumorigenesis. The objective of this study was to investigate the utilization of electrospraying process to fabricate minocycline‐loaded poly(lactic‐co‐glycolic acid) (PLGA) microparticles with high drug loading and loading efficiency and to evaluate their ability to induce cell toxicity in human glioblastoma (i.e., U87‐MG) cells. The results from this study demonstrated that solvent mixture of dicholoromethane (DCM) and methanol is the optimal solvent combination for minocycline and larger amount of methanol (i.e., 70:30) resulted in a higher drug loading. All three solvent ratios of DCM:methanol tested produced microparticles that were both spherical and smooth, all in the micron size range. The electrosprayed microparticles were able to elicit a cytotoxic response in U87‐MG glioblastoma cells at a lower concentration of drug compared to the free drug. This work provides proof of concept to the hypothesis that electrosprayed minocycline‐loaded PLGA microparticles can be a promising agent for the treatment of GBM and could have potential application for cancer therapies.
Occupational health and safety management policies and employee quality of life in developing countries: Insights from Ghana
Authors: Atarah Bede Akorige , Frimpong Naana , Ahwireng Patience Obeng 
Published: August 2023

AbstractThis study explores the formulation and implementation of occupational health and safety management (OHSM) policies by multinational manufacturing firms operating in sub‐Saharan Africa and how they influence employees' quality of life (QOL). We used Afrifoods (pseudonym), a food manufacturing multinational company in Ghana as a case. Gathering qualitative data through interviews, focus group discussions, and archival sources, we found that despite the prevailing institutional deficiencies in sub‐Saharan African countries especially in ensuring the implementation of health and safety policies, food manufacturing multinational companies formulate and implement health and safety policies. And, the high rates of unemployment notwithstanding, employees of manufacturing companies prioritize safe and healthy working environment and consider it the first and most important attribute of their QOL. Employees also consider being able to provide their family needs as well as being recognized for the efforts expended at work as other determinants of their QOL. Multinational firms operating or intending to go into sub‐Saharan Africa should consider health and safety policies as indispensable in their business strategy formulation, if they wish to get the maximum benefit from their employees. Governments must also intensify monitoring to ensure firms' compliance with national health and safety laws at their work sites.
Determinants of social innovation in hybrid organisations: The moderating role of technology readiness
Authors: Erdiaw‐Kwasie Michael Odei , Abunyewah Matthew 
Published: August 2023

AbstractA balance between economic, social, and ecological performance has emerged as a key concern for organisations around the world. The modern era emphasises achieving eco‐friendly business outcomes to drive social needs along with higher financial performance. However, hybrid organisations in developing countries frequently progress in ecological and economic terms but struggle with social innovation. Based on this backdrop, this study aimed to investigate whether or not technological readiness, organisational learning, transformational leadership, and sustainability orientation influence social innovation within hybrid organisations. Data from 447 hybrid organisations in Ghana are used in the study. Study findings reveal that transformational leadership promotes social innovation among hybrid enterprises, while sustainability orientation decreases it significantly. Technology readiness also reduced the social outcome associated with sustainability orientation by moderating their negative effects. To maximise social innovation outcomes, this study recommends managers of hybrid organisations to adopt policies regarding the efficient use of internal resources and processes through technological readiness. Furthermore, the organisation's future learning processes, leadership structures, and sustainability orientation policies should be aligned with its social innovation goals.
Clinical characteristics of malignant germ cell tumors in adolescents: A multicenter 10‐year retrospective study in Beijing
Authors: Zhao Qian , Li Miao , Sun Qing , Zhi Tian , Jin Mei , Zhao Wen , Wang Xisi , Duan Chao , Ma Xiaoli , Wu Wanshui , Zhao Weihong , Huang Dongsheng , Su Yan 
Published: August 2023

AbstractBackgroundThe aim of this study was to review clinical features of adolescent malignant germ cell tumors (MGCTs) in Beijing and analyze the peculiar characteristics of this age group.MethodsClinical characteristics, pathological presentations, and survival outcomes of 34 patients were analyzed retrospectively.ResultsOf 34 patients, 12 girls and 22 boys, 18 (52.9%) had an extra‐cranial tumor, including one testicular tumor, five ovarian tumors, one sacrococcygeal tumor, and 11 mediastinal tumors. Histologically, we found immature teratomas (n = 6), yolk sac tumors (n = 5), mixed malignant tumors (n = 5), an embryonic carcinoma (n = 1), and seminoma (n = 1). Three‐year event‐free survival (EFS) and overall survival (OS) were 48.8% and 62.9%, respectively. Another 16 (47.1%) patients had an intracranial tumor, including nine in the pineal region, five in the suprasellar region, one in basal ganglia, and one in cerebellopontine. All patients had localized disease and an excellent outcome with 3‐year EFS and OS of 93.7% and 100%, respectively.ConclusionsAdolescent MGCTs are rare with a strong dependence on gender, and the mediastina and pineal region are the most common tumor locations. The prognosis is promising compared with that of other adolescent tumors and MGCTs in other age groups. MGCTs in mediastina have a tendency to companion with other hematological malignancies, and the prognosis is extremely poor in these patients.
Synthesis, in Silico Study and Biological Evaluation of N‐(Benzothiazol/Thiazol‐2‐yl)benzamide Derivatives as Quorum Sensing Inhibitors against Pseudomonas aeruginosa
Authors: Sharma Nikhil , Srivastava Namita , Kaushal Ashutosh , Das Bhanuranjan , Vashistha Aditi , Kumar Lokender , Kumar Rajnish , Kumar Yadav Ashok 
Published: August 2023

AbstractThe development of bacterial resistance to chemical therapy poses a severe danger to efficacy of treating bacterial infections. One of the key factors for resistance to antimicrobial medications is growth of bacteria in biofilm. Quorum sensing (QS) inhibition was created as an alternative treatment by developing novel anti‐biofilm medicines. Cell‐cell communication is impeded by QS inhibition, which targets QS signaling pathway. The goal of this work is to develop newer drugs that are effective against Pseudomonas aeruginosa by decreasing QS and acting as anti‐biofilm agents. In this investigation, N‐(benzo[d]thiazol‐2‐yl)benzamide/N‐(thiazol‐2‐yl)benzamide derivatives 3a‐h were designed and synthesized in good yields. Further, molecular docking analyses revealed that binding affinity values were founded −11.2 to −7.6 kcal/mol that were moderate to good. The physicochemical properties of these prepared compounds were investigated through in‐silico method. Molecular dynamic simulation was also used to know better understanding of stability of the protein and ligand complex. Comparing N‐(benzo[d]thiazol‐2‐yl)benzamide 3a to salicylic acid (4.40±0.10) that was utilised as standard for quorum sensing inhibitor, the anti‐QS action was found greater for N‐(benzo[d]thiazol‐2‐yl)benzamide 3a (4.67±0.45) than salicylic acid (4.40±0.10). Overall, research results suggested that N‐(benzo[d]thiazol‐2‐yl)benzamide/N‐(thiazol‐2‐yl)benzamide derivatives 3a‐h may hold to develop new quorum sensing inhibitors.
Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway
Authors: Luo Jing , Deng Yijue , Ding Yi , Tang Chenguang , Wang Mengqing 
Published: August 2023

AbstractThis study aimed to determine the effects of Xiebai Zengye decoction (XBZY) on airway inflammation and respiratory function in rats with postinfectious cough (PIC), and its regulatory effects on the extracellular signal‐regulated kinase (ERK) signaling pathway. Compared with the normal group, the rats from the PIC group had significantly shortened expiratory time (TE) and enhanced pause (EEP), increased resistance (RT), and enhanced pause (Penh), along with increased levels of serum interleukin‐4 (IL‐4) and IL‐6, and decreased levels of IL‐10. The lung and colon tissues of rats from the PIC group showed histopathological changes, including inflammatory cell infiltration, damaged mucosal epithelium, and crypt structure, with significantly increased ERK mRNA and protein expression levels. Treatment with XBZY and montelukast sodium (MAS) improved the respiratory function and serum cytokine levels, reduced tissue inflammation, and decreased ERK mRNA and protein expression levels in the lung and colon tissues. In the lung tissues, XBZY treatment significantly decreased the expression of phosphorylated‐ERK (p‐ERK) protein, as well as p‐MEK1/2, p‐ERK1/2, and p‐c‐Fos proteins, while in the colon tissues, XBZY significantly decreased the expression of p‐ERK1/2 and p‐c‐Fos proteins. However, MAS treatment only showed significant improvement in the lung tissue inflammation score, and the expression level of p‐ERK protein in the lung tissue was decreased. In conclusion, the present study suggests that XBZY has a potential therapeutic effect on PIC by improving respiratory function and attenuating inflammation, and this effect may be associated with the inhibition of the ERK signaling pathway. These findings could provide a new direction for the development of treatments for PIC. However, further research is needed to elucidate the underlying molecular mechanisms of XBZY and to confirm its safety and efficacy in clinical trials.