bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cathepsins: Novel opportunities for antibody therapeutics in cancer
Authors: David Timothée , du Roure Pénélope Desroys , Mallavialle Aude , Laurent‐Matha Valérie , Roger Pascal , Guiu Séverine , Chardès Thierry , Liaudet‐Coopman Emmanuelle 
Published: January 2025

AbstractCathepsins, the most abundant lysosomal proteases, have key functions in cell maintenance and homeostasis. They are overexpressed and hypersecreted in cancer and associated with poor prognosis. Secreted cathepsins display pro‐tumour activities in the tumour microenvironment and thus represent interesting molecular targets in oncology. Recently, several antibody‐based cancer therapies have targeted the pro‐tumour activity of the extracellular cathepsin pool, altering several cancer hallmarks, but not the intracellular cathepsin levels that are often crucial for cell homeostasis. In this mini‐review, we describe advances in antibodies against extracellular cathepsins in cancer, and their effect on the proteolytic cascade, matrix remodelling, proliferation, and modulation of the anti‐cancer immune response. We also discuss the add‐on value of combination strategies (anti‐cathepsin antibodies with chemotherapy and/or biologics) that make anti‐cathepsin antibodies a new opportunity for disease management.
Be(com)ing Family: A Systematic Review of Stakeholders' Perspectives on Family in Family Foster Care
Authors: Wulleman Lara , Grietens Hans , Noens Ilse , Vliegen Nicole 
Published: January 2025

ABSTRACTWhen a child enters a foster family, it weaves an intricate web that profoundly changes the relationships and bonds of all involved, making it difficult to define ‘family’ using predefined criteria. Despite the far‐reaching impact on all involved, no previous study has systematically reviewed and qualitatively analysed how parents, foster carers, children of foster carers and foster care workers in kith, kinship or nonkinship care understand family. This study examines the characteristics of studies examining stakeholders' family understandings, how stakeholders define family and whom they consider family. Following PRISMA guidelines, 18 studies were included and analysed using a reflexive thematic analysis. Results show a plurality of family meanings, encompassing perceptions of family in the context of care and support, biological and legal dimensions of family, emotional and relational aspects of family and family as a site of stability and transition. These meanings also involve intricate aspects, such as the thin line between devotion and duty in kith and kinship caregiving. Who stakeholders considered family could be categorized as ‘blood relatives as ‘natural’ family members’, ‘legally bounded family membership’, ‘chosen family’, ‘differing views on who is family’ and ‘reconciling all family perspectives in the foster care system’. Implications for research, practice and policymaking are discussed.
Evaluation of the Accuracy, Surgical Time, and Learning Curve of Freehand, Static, and Dynamic Computer‐Assisted Implant Surgery in an In Vitro Study
Authors: Werny Joscha Gabriel , Fan Shengchi , Diaz Leonardo , Al‐Nawas Bilal , Sagheb Keyvan , Gielisch Matthias , Schiegnitz Eik 
Published: January 2025

ABSTRACTObjectivesThis experimental study compared the accuracy of implant insertion using the free‐hand (FH) technique, static computer‐aided surgery (S‐CAIS), or dynamic computer‐assisted surgery (D‐CAIS) and to evaluate the correlation of learning curves between surgeons' experience and surgical time.Materials and MethodsThirty‐six models were randomly assigned to three groups (FH, n = 12; S‐CAIS, n = 12; D‐CAIS, n = 12). Each model was planned to receive four implants in the maxillary anterior and posterior regions. Twelve participants, six experienced surgeons, and six dental students were included in this study. The primary outcome was the deviation between the planned and final implant placement from each group. Secondary outcomes were each technique's learning curve regarding surgical time.ResultsThe average deviation at implant platform, apex and gradual deviation with FH technique were 1.31 ± 0.88 mm, 1.75 ± 0.9 mm and 6.67° ± 3.70°, respectively. The average deviation of implant platform, apex and angular in S‐CAIS were 0.67 ± 0.32 mm, 1.00 ± 0.39 and 2.66° ± 1.77°, respectively. The average deviation of implant platform, apex and angular in D‐CAIS were 1.14 ± 0.70 mm, 1.23 ± 0.58 and 3.20° ± 2.16°, respectively. Significant discrepancies at the implant platform, implant apex, and angular deviation were found between all surgical methods (p < 0.016). Learning curves were evident after multiple implant insertions using both freehand and S‐CAIS.ConclusionThe findings indicate that computer‐assisted implant insertion leads to a more precise implant alignment than implants inserted freehand in an experimental set‐up.
Meteorin‐like protein plasma levels are associated with worse outcomes in de novo heart failure
Authors: Anido‐Varela Laura , Aragón‐Herrera Alana , González‐Maestro Adrián , Bellas Carlos Tilves , Tarazón Estefanía , Solé‐González Eduard , Martínez‐Sellés Manuel , Guerra‐Ramos José María , Carrasquer Anna , Morán‐Fernández Laura , García‐Vega David , Seoane‐Blanco Ana , Moure‐González María , Seijas‐Amigo Jose , Rodríguez‐Penas Diego , García‐Seara Javier , Moraña‐Fernández Sandra , Vázquez‐Abuín Xocas , Roselló‐Lletí Esther , Portolés Manuel , Eiras Sonia , Agra Rosa M. , Álvarez Ezequiel , González‐Juanatey José R. , Feijóo‐Bandín Sandra , Lago Francisca ,   The REDINSCOR III registry
Published: January 2025

AbstractBackground and AimsMeteorin‐like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated with heart failure (HF), although with contradictory results. Our aim was to ascertain whether this adipokine could estimate the prognosis of HF in de novo HF (DNHF) patients.MethodsMetrnl plasma levels of 400 patients hospitalized with DNHF (55% of patients with HF with reduced ejection fraction, 17.3% HF with mid‐range ejection fraction, 27.8% HF with preserved ejection fraction) were measured by enzyme‐linked immunosorbent assay. We performed both sex‐pooled and sex‐specific analyses. A 12‐month follow‐up was conducted, during which clinical outcomes such as all‐cause mortality, cardiovascular death and re‐hospitalization due to HF were collected.ResultsAfter a 12‐month follow up, higher plasma Metrnl levels were associated with an increased risk for all‐cause death and cardiovascular death after adjusting by sex, age, LVEF, hypertension, diabetes, ischemic aetiology, chronic renal failure, NT‐proBNP and troponin (hazard ratio [HR] = 1.003, 95% confidence interval [CI] = 1.000–1.005; p‐value<.05 and HR = 1.004, 95% CI = 1.001–1.007, p‐value<.05, respectively). In line with this, DNHF patients with increased levels of circulating Metrnl had a higher number of occurrences of cardiovascular events. Regarding Metrnl associations with parameters implicated in the development and progression of HF, we found that Metrnl circulating levels were positively correlated with age (r = .322, p‐value<.0001), NT‐proBNP (r = .281, p‐value<.0001) and with the renal dysfunction markers urea (r = .322, p‐value<.0001) and creatinine (r = .353, p‐value<.0001) and higher in women than men (473.7 [385.9–594.0] pg/mL vs. 428.7 [349.1–561.3] pg/mL, p‐value<.006). Finally, concerning the subtype of HF, Metrnl plasma levels were higher in HF with preserved ejection fraction.ConclusionPatients with higher Metrnl levels have a worse prognosis in DNHF. Our results reinforce the association of Metrnl plasma levels with HF progression and outcomes.
Rising Tides, Sinking Approval Rates: Examining SLR Risk and Mortgage Credit Access
Authors: Fu Chengbo , Huang Qiping , Lin Meimei , Tahsin Salman 
Published: January 2025

ABSTRACTWe measure sea‐level rise (SLR) risk using two indicators: SLR Impact (whether a census tract would be inundated under a 1‐ft SLR) and SLR Exposure (percentage of land inundated under a 1‐ft SLR). SLR‐impacted areas see 0.36%–1% lower mortgage approval rates, with a 10% increase in SLR Exposure reducing approvals by 14 basis points. These patterns reflect future SLR risk expectations rather than past flood or hurricane events. We also find higher denial rates in regions with stronger climate risk beliefs and greater SLR risk. Additionally, SLR‐related mortgage denials disproportionately affect minority groups.
Policy interactions at a multiscale geographical space for developing the green economy: Evidence from the international diffusion of environmental goods
Authors: Gui Jingxuan , Mao Xiyan , Wang Peiyu 
Published: January 2025

AbstractThe institutional and multi‐scale perspective provide a promising nexus between economic geography and environmental governance. They help to overcome the duality of the global–local nexus for regions in a globalising world, enabling the rediscovery of the role of states and their governance. This article proposes that the scalar structure of institutional linkages is not continuous from the global to the local, where the state level is a discontinuity. The supra‐national interdependence is horizontal and the sub‐national governance is hierarchical. They interact with each other to affect the path development of new economies. International trade in environmental goods during 2001–19 is used as an empirical case. The results show that the liberalising trade policies (international interdependencies) open a window of opportunity for countries to develop a green economy, while domestic industrial and environmental policies (domestic governance) help to anchor the opportunities by enhancing the effect of trade policies. These results show that an enabling system of environmental governance requires a multi‐scalar structure that includes states. Domestic governance allows the states to adapt to the global governance regime, and then seize the development opportunities offered by international interdependencies. The states play a crucial role in balancing the multi‐scale interactions in the global governance regime. This is different from what the conventional global–local nexus might conclude.
The Experience of Stigma in People Affected by Fibromyalgia: A Metasynthesis
Authors: Colombo Benedetta , Zanella Eleonora , Galazzi Alessandro , Arcadi Paola 
Published: January 2025

ABSTRACTAimTo review the qualitative literature regarding how people with fibromyalgia experience and are impacted by stigma.DesignA systematic review and metasynthesis of qualitative studies was conducted following the Thomas and Harden method.MethodsThe electronic databases PubMed, CINAHL, PsycInfo, Embase and Scopus were queried (September 2023). No publication year limit was set. Twelve studies were included in the final analysis. The findings were reported according to the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) statement.FindingsThree main themes with 11 sub‐themes were identified: manifestations and roots of stigma, avoidance and coping strategies, and consequences of stigma. Stigma arises from disbelief due to the invisibility of symptoms, protracted time to diagnosis and gender stereotyping, especially against women. Various strategies to avoid or cope with prejudice may involve social isolation, hiding the disease, controlling information, getting closer to or further away from other patients, acknowledging and understanding the disease. Stigmatisation can diminish a person's integrity and dignity, undermine trust in health care professionals and worsen suffering.ConclusionThe metasynthesis findings align with previous research highlighting the pervasive stigma associated with chronic pain conditions. Greater awareness of the impact of disease‐related stigma on individuals with fibromyalgia is crucial, not only among health care professionals but also within broader societal and institutional contexts.Implications for the Profession and/or Patient CareUnderstanding the stigma experienced by individuals with fibromyalgia can guide health care professionals in adopting more empathtic approaches, potentially improving the diagnostic process and the overall management of the condition.ImpactThis study highlights the profound impact of stigma on individuals with fibromyalgia, emphasising the need for greater awareness and targeted interventions to address stigma in clinical practice and societal contexts.Patient or Public ContributionNo patient or public contribution.
Graphical Model Selection to Infer the Partial Correlation Network of Allelic Effects in Genomic Prediction With an Application in Dairy Cattle
Authors: Martínez Carlos A. , Khare Kshitij , Rahman Syed , Báez Giovanni M. 
Published: January 2025

ABSTRACTWe addressed genomic prediction accounting for partial correlation of marker effects, which entails the estimation of the partial correlation network/graph (PCN) and the precision matrix of an unobservable m‐dimensional random variable. To this end, we developed a set of statistical models and methods by extending the canonical model selection problem in Gaussian concentration, and directed acyclic graph models. Our frequentist formulations combined existing methods with the EM algorithm and were termed Glasso‐EM, Concord‐EM and CSCS‐EM, whereas our Bayesian formulations corresponded to hierarchical models termed Bayes G‐Sel and Bayes DAG‐Sel. We implemented our methods in a real bull fertility dataset and then carried out gene annotation of seven markers having the highest degrees in the estimated PCN. Our findings brought biological evidence supporting the usefulness of identifying genomic regions that are highly connected in the inferred PCN. Moreover, a simulation study showed that some of our methods can accurately recover the PCN (accuracy up to 0.98 using Concord‐EM), estimate the precision matrix (Concord‐EM yielded the best results) and predict breeding values (the best reliability was 0.85 for a trait with heritability of 0.5 using Glasso‐EM).
YouTube Videos of Pacemaker Implantation: An Assessment of Information Content and Quality
Authors: Tang Pok‐Tin , Camm C. Fielder , Rajappan Saffron , Sale Richard D. , Rajappan Kim 
Published: January 2025

ABSTRACTBackgroundPermanent pacemaker (PPM) implantation is a commonly performed procedure. Patients increasingly use the Internet for information on medical interventions. We aimed to assess the quality of videos discussing PPM implantation on YouTube for patient consumption.MethodsYouTube was searched on October 19, 2022, for “PPM implantation” and “Pacemaker.” The first 100 results from each search were screened: all English language videos containing predominant discussion of transvenous PPMs were included; YouTube shorts and advertisements were excluded. Two authors independently assessed videos for information content based on criteria generated using established patient resources supplemented by expert consensus. Video reliability and quality were assessed using a novel scoring system.ResultsThirty‐three videos with a cumulative total of 5 864 488 views were included. No video contained all essential information criteria. The average number of essential criteria covered was 8/32 (standard deviation 4.8). Peri‐operative management was, particularly, poorly covered: no item relating to preoperative management or postoperative care was covered by more than 40% of videos. None of the videos fulfilled all quality criteria, with a median score of 7.5/13 (interquartile range 6.5–8). Videos performed, particularly, poorly on providing balanced messages, creator disclosures, attribution of source content, and indicating when videos were made.ConclusionYouTube videos of PPM implantation do not contain sufficient information to allow patients to gain an appropriate understanding of this procedure. Furthermore, the information presented is of insufficient quality to support decision‐making. There is a need for a professionally regulated, comprehensive audiovisual patient resource on PPM implantation.
Dependence matters! Investor sentiment and stock returns: A sliced inverse regression approach
Authors: He Lingyu , Shi Jing , Wang Yizhi , Zhu Qiaoqiao 
Published: January 2025

AbstractWe construct a new investor sentiment index by exploiting the information of the sentiment proxies with the sliced inverse regression approach. We show that the new index is a strong negative predictor of future aggregate stock returns in both in‐sample and out‐of‐sample tests. Further evidence indicates that the new sentiment index generates large utility gains for a mean‐variance investor who optimally allocates between equities and risk‐free assets. In addition, we show that this sentiment index exhibits the strongest return predictability for portfolios sorted on size, value, momentum, and industry.
Nomograph of cancer‐specific survival in elderly patients with endometrial cancer based on SEER database
Authors: Ma Fanghua , Huang Jiesheng 
Published: January 2025

AbstractObjectiveThis study aims to identify prognostic factors for elderly patients with endometrial cancer and to develop a nomogram for predicting cancer‐specific survival in this population.MethodsClinicopathological data of elderly patients diagnosed with endometrial cancer between 2004 and 2015 were extracted from the SEER database. Patients were randomly assigned to either a training cohort or a validation cohort at a ratio of 7:3. Univariate and multivariable Cox regression analyses were performed to identify independent prognostic factors. A nomogram was then constructed based on these factors, and its predictive accuracy and discriminative ability were assessed using the C‐index, receiver operating characteristic (ROC), and calibration curve.ResultsMultivariate analysis identified age, marital status, grade, Federation of International of Gynecology and Obstetrics, surgery, chemotherapy, radiation, and tumor size as independent prognostic factors for elderly patients with endometrial carcinoma. Nomograms derived from these factors demonstrated excellent calibration and discrimination. The C‐indexes were 0.83 for the training set and 0.82 for the validation set. The area under the curve (AUC) values for the training set were 0.88, 0.87, and 0.86 at 1, 3, and 5 year respectively. Corresponding AUC values for the validation set were 0.89, 0.86, and 0.86. Calibration curves for both cohorts demonstrated close alignment with the diagonal, indicating robust agreement between nomogram predictions and actual outcomes.ConclusionA novel nomogram has been developed for personalized prognosis assessment in elderly patients with endometrial carcinoma, aiming to enhance tailored treatment strategies and clinical management.
Clinical outcomes after 2‐year follow‐up of transvaginal radiofrequency ablation of symptomatic uterine fibroids
Authors: Santalla‐Hernández Ángel , Naveiro‐Fuentes Mariña , López‐Criado María Setefilla , Naveiro‐Flores Roi , Fernández‐Parra Jorge 
Published: January 2025

AbstractAimThe aim of this study was to evaluate the efficacy after 2 years follow‐up of transvaginal radiofrequency ablation (TVRA) to treat myomas, and to identify factors predictive of the response to the treatment.MethodsThis is a prospective cohort study of a 2‐year follow‐up of 65 patients who underwent TVRA for the treatment uterine fibroids at Virgen de las Nieves University Hospital in Granada, Spain. Ultrasound mean fibroid volume, symptom severity scale, total bleeding days, complications, pregnancy outcomes were recorded.ResultsStatistically significant improvements in symptoms and bleeding were observed at 6, 12, and 24 months after the procedure. The mean myoma volume (cc) was significantly lower (p < 0.05) at 12 and 24 months, with a mean reduction in myoma volume of more than 80% and 60%, respectively. After a 24‐month follow‐up, 5 patients (7.7%) required additional surgical treatment to control symptoms. Patient age (>40 years), initial myoma size, and the timing of radiofrequency were identified as factors related to outcomes in the bivariate analysis.ConclusionsTransvaginal radiofrequency ablation is an effective and safe technique for the treatment of myomas after 2 years of follow‐up, which improves the symptoms of the patients and decreases the final volume of the myoma.
How Imprints Transcend Era and Terra: A Study of Firms' Controversial History and Present‐Day Foreign Market Entry
Authors: Qiao Kunyuan , Xia Jun 
Published: January 2025

AbstractHow do certain historical events transcend generational and geographic boundaries to shape firm strategy? We explore this question by examining how certain German firms' present‐day foreign market entry is influenced by their past leaders' support of Hitler and the Nazi Party, or Nazi imprint. We argue that this imprint persists through two mechanisms: (1) internal organizational alertness to their controversial past and (2) external collective memory sustained by Jewish communities worldwide. When Nazi‐imprinted German firms consider entering locations where their past might provoke controversy, they tend to seek informational cues from peers with the same imprint. This results in a positive relationship between the number of subsidiaries their peers have in such controversial locations and the number of new subsidiaries established by the focal firm. To illustrate these mechanisms, we argue that the communist purge in the former East Germany has reduced organizational alertness to the controversial past and thus weakened the relationship. In contrast, commemorative efforts by synagogues around the world have strengthened the collective memory, thereby reinforcing the relationship. We employ two longitudinal samples to test these hypotheses, focusing on German firms' entries into (1) non‐German cities worldwide with significant Jewish populations and (2) US counties with neo‐Nazi hate groups. We obtain robust evidence supporting our hypotheses. By demonstrating the role of extra‐organizational carriers in maintaining historical imprints and challenging the notion that inertia alone sustains them, our research advances imprinting theory and sheds light on the role of history in international business.