bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUTU PENDIDIKAN ISLAM: JENIS KESISTEMAN, KONSTRUKSI KESISTEMAN DAN BERFIKIR KESISTEMAN
Authors: Fardinal Fardinal , Ali Hapzi , Anwar US Kasful 
Published: September 2023

Dalam meningkatkan Mutu Pendidikan Islam sangat di perlukan Perubahan dan usaha yang lebih baik lagi, di karenakan tantangangan zaman yang akan datang menuntut lembaga pendidikan islam untuk mengikuti perkembangan zamannya, untuk menumbuhkan kepercayaan dan minat masyarakat sangat perlu peningkatan Mutu pendidikan itu sendiri, agar anak anak yang mereka titipkan pada Lembaga pendidikan Islam mampu bersaing dan mampu mengahadapi era saat ini. Pendekatan sistem atau berpikir kesisteman adalah salah satu solusi mendasar yang harus dipahami dan diterapkan oleh setiap manajer lembaga pendidikan Islam agar Lembaga Pendidikan Islam menjadi Lembaga pendidikan yang bermutu. Artikel ini mereview Faktor-faktor yang mempengaruhi Mutu Pendidikan Islam, yaitu: Jenis Kesisteman, Konstruksi Kesisteman dan Berfikir Kesisteman, suatu studi literatur Manajemen Sumberdaya Manusia. Tujuan penulisan artikel ini guna membangun hipotesis pengaruh antar variabel untuk digunakan pada riset selanjutnya. Hasil artikel literature review ini adalah: 1) Jenis Kesisteman berpengaruh terhadap Mutu Pendidikan Islam; 2) Konstruksi Kesisteman berpengaruh terhadap Mutu Pendidikan Islam; dan 3) Berfikir Kesisteman berpengaruh terhadap Mutu Pendidikan Islam.
Faktor-Faktor Yang Mempengaruhi Tingkat Deviasi Halaman III DIPA pada Satker Lingkup Kemenag Bangka Belitung
Authors: Arnida Arnida 
Published: September 2023

Tujuan penulisan ini adalah untuk meneliti faktor-faktor yang mempengaruhi tingkat deviasi halaman III DIPA dengan studi penelitian pada satker lingkup kementerian agama provinsi Bangka Belitung. Penilaian kinerja atas pelaksanaan anggaran pada satuan kerja diukur melalui sebuah tool yang dinamakan Indikator Kinerja Pelaksanaan Anggaran (IKPA) yang menilai aspek perencanaan, pelaksanaan, dan aspek hasil. Indikator deviasi halaman III DIPA merupakan salah satu indikator pada aspek kualitas perencanaan anggaran. Pada tahun 2020 dan 2021, indikator deviasi halaman III DIPA menjadi indikator yang selalu muncul sebagai salah satu indikator yang tidak mencapai target. Nilai pada indikator ini menunjukkan kualitas penyusunan perencanaan penarikan dana yang tertuang pada Halaman III DIPA yang disusun oleh satker . Dari sisi lain, kurang akuratnya rencana penarikan dana ini dapat mempengaruhi kredibilitas pemerintah dalam hal memenuhi ketersediaan dana kas negara untuk keperluan belanja yang dibiayai oleh Anggaran Pendapatan Belanja Negara (APBN).
Pengaruh Disiplin Kerja, Motivasi Kerja dan Budaya Organisasi Melalui Kepuasan Kerja sebagai Variabel Mediasi terhadap Pengembangan Karir (Suatu Kajian Studi Literatur Manajemen Sumberdaya Manusia)
Authors: Dias Amaral Feodora , EHJ FoEh John , Man Stanis , Ayu Diah 
Published: September 2023

Karya ilmiah ini mengulas mengenai kajian pustaka, terutama faktor yang berpengaruh kepada pengembangan karier: kepuasan kerja sebagai variabel intervening, serta disiplin kerja, motivasi kerja maupun budaya organisasi. Karya ilmiah ini peneliti tulis agar bisa menentukan hipotesis yang berpengaruh ke antarvariabel supaya bermanfaat bagi penulisan selanjutnya. Hasil yang didapat ialah disiplin kerja berakibat positif dan penting kepada pengembangan karir; motivasi kerja berakibat positif dan penting kepada pengembangan karir; budaya organisasi berakibat positif dan penting kepada pengembangan karir; disiplin kerja berakibat positif dan penting kepada kepuasan kerja; motivasi kerja berakibat positif dan penting kepada kepuasan kerja; budaya organisasi berakibat positif dan penting kepada kepuasan kerja; dan kepuasan kerja mempengaruhi positif maupun krusial bagi pengembangan karir.
Approximate Model-Based Shielding for Safe Reinforcement Learning
Authors: Goodall Alexander W. , Belardinelli Francesco 
Published: September 2023

Reinforcement learning (RL) has shown great potential for solving complex tasks in a variety of domains. However, applying RL to safety-critical systems in the real-world is not easy as many algorithms are sample-inefficient and maximising the standard RL objective comes with no guarantees on worst-case performance. In this paper we propose approximate model-based shielding (AMBS), a principled look-ahead shielding algorithm for verifying the performance of learned RL policies w.r.t. a set of given safety constraints. Our algorithm differs from other shielding approaches in that it does not require prior knowledge of the safety-relevant dynamics of the system. We provide a strong theoretical justification for AMBS and demonstrate superior performance to other safety-aware approaches on a set of Atari games with state-dependent safety-labels.
Automatic Parallel Portfolio Selection
Authors: Kashgarani Haniye , Kotthoff Lars 
Published: September 2023

Algorithms to solve hard combinatorial problems often exhibit complementary performance, i.e. where one algorithm fails, another shines. Algorithm portfolios and algorithm selection take advantage of this by running all algorithms in parallel or choosing the best one to run on a problem instance. In this paper, we show that neither of these approaches gives the best possible performance and propose the happy medium of running a subset of all algorithms in parallel. We propose a method to choose this subset automatically for each problem instance, and demonstrate empirical improvements of up to 19% in terms of runtime, 81% in terms of misclassification penalty, and 26% in terms of penalized averaged runtime on scenarios from the ASlib benchmark library. Unlike all other algorithm selection and scheduling approaches in the literature, our performance measures are based on the actual performance for algorithms running in parallel rather than assuming overhead-free parallelization based on sequential performance. Our approach is easy to apply in practice and does not require to solve hard problems to obtain a schedule, unlike other techniques in the literature, while still delivering superior performance.
Seeing Like a Market: to the Question of the Ethical Assessment of the Privatization of East German Companies in 1990–1994
Authors: Mironov V. A. 
Published: September 2023

The article deals with the problem of ethical assessment of the liquidation of the GDR as a state structure and its integration into the political and economic space of the FRG. According to a number of historical and sociological sources, “reunification” was not the reason for the search and finding of a common language between West and East Germans, but, on the contrary, the reasons for discord and deep mutual distrust and rejection. On this basis, the work analyzes the views of both sides, and also conducts a philosophical reflection on the value bases (ethical axioms) of the key evaluative positions of both East and West Germans regarding the actions of the West German government, the conditions for concluding a monetary union of the two Germanys, as well as in relation to privatizations East German companies.
Effect of low-dose blanched Saccharina latissima in finishing bulls’ diets on carcass and meat quality traits
Authors: Grabež Vladana , Mydland Liv Torunn , Papoutsis Dimitrios , Øverland Margareth , Egelandsdal Bjørg 
Published: September 2023

Nutritional and bioactive compounds present in seaweeds make them suitable supplements or feed ingredients in livestock diets. This study assessed the effect of blanched seaweed (Saccharina latissima) as a supplement in finishing bulls’ diets on carcass traits and the quality of the longissimus lumborum (LL) and semimembranosus (SM) muscles. A concentration of 0.8% dry matter of blanched S. latissima in bulls’ diets was the maximum amount allowed, owing to iodine and arsenic thresholds in animal feed. Nineteen Limousin crossbreed bulls were randomly assigned to two groups, fed a control (CD, n = 9) diet or a test diet supplemented with blanched seaweed (SW, n = 10), and fed for 48 days pre slaughter. The carcasses from the bulls finished on a seaweed-supplemented diet were heavier (p &lt; 0.05) than those in the control group, while levels of conformation and fatness were similar between the groups (p &gt; 0.05). The pH was lower (p &lt; 0.05) in the LL of CD-fed animals in early post mortem than in the LL of SW-fed animals, whereas no differences (p &gt; 0.05) were found in the ultimate pH. The meat from the bulls fed both diets had a similar (p &gt; 0.05) drip loss and shear force at days 7 and 14. The cooking loss at day 7 was not affected (p &gt; 0.05) by diet, whereas on day 14 the cooking loss was greater (p &lt; 0.05) for SW than for CD meat. Warmed-over flavor and shear force were muscle dependent and lower (p &lt; 0.05) for LL than SM. Seaweed supplementation in finishing bulls’ diets had no clear effect on color changes (L*, a*, and b* values) during chilled storage, although reduced b* values (p &lt; 0.05) suggest an improved color stability of meat from SW- compared with CD-fed animals. The iodine content was higher (p &lt; 0.05) in the SW meat than in the CD meat, even when using the low seaweed supplementation level requested by the authorities. A small increase of arsenic in the meat with seaweed supplementation has no implications on human health. Cost-efficient processing methods for the further reduction of iodine and arsenic are needed to increase the utilization of seaweed as a feed additive/ingredient and attain a clear effect on meat quality.
ICOSLG-associated immunological landscape and diagnostic value in oral squamous cell carcinoma: a prospective cohort study
Authors: Dong Yuexin , Hu Xinyang , Xie Shixin , Song Yuxian , He Yijia , Jin Wanyong , Ni Yanhong , Wang Zhiyong , Ding Liang 
Published: September 2023

Background: We previously reported that stroma cells regulate constitutive and inductive PD-L1 (B7-H1) expression and immune escape of oral squamous cell carcinoma. ICOSLG (B7-H2), belongs to the B7 protein family, also participates in regulating T cells activation for tissue homeostasis via binding to ICOS and inducing ICOS+ T cell differentiation as well as stimulate B-cell activation, while it appears to be abnormally expressed during carcinogenesis. Clarifying its heterogeneous clinical expression pattern and its immune landscape is a prerequisite for the maximum response rate of ICOSLG-based immunotherapy in a specific population.Methods: This retrospective study included OSCC tissue samples (n = 105) to analyze the spatial distribution of ICOSLG. Preoperative peripheral blood samples (n = 104) and independent tissue samples (n = 10) of OSCC were collected to analyze the changes of immunocytes (T cells, B cells, NK cells and macrophages) according to ICOSLG level in different cellular contents.Results: ICOSLG is ubiquitous in tumor cells (TCs), cancer-associated fibroblasts (CAFs) and tumor infiltrating lymphocytes (TILs). Patients with high ICOSLGTCs or TILs showed high TNM stage and lymph node metastasis, which predicted a decreased overall or metastasis-free survival. This sub-cohort was featured with diminished CD4+ T cells and increased Foxp3+ cells in invasive Frontier in situ, and increased absolute numbers of CD3+CD4+ and CD8+ T cells in peripheral blood. ICOSLG also positively correlated with other immune checkpoint molecules (PD-L1, CSF1R, CTLA4, IDO1, IL10, PD1).Conclusion: Tumor cell-derived ICOSLG could be an efficient marker of OSCC patient stratification for precision immunotherapy.
Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot
Authors: Harvey Drayton C. , Verma Riya , Sedaghat Brandon , Hjelm Brooke E. , Morton Sarah U. , Seidman Jon G. , Kumar S. Ram 
Published: September 2023

ObjectiveEighty percent of patients with a diagnosis of tetralogy of Fallot (TOF) do not have a known genetic etiology or syndrome. We sought to identify key molecular pathways and biological processes that are enriched in non-syndromic TOF, the most common form of cyanotic congenital heart disease, rather than single driver genes to elucidate the pathogenesis of this disease.MethodsWe undertook exome sequencing of 362 probands with non-syndromic TOF and their parents within the Pediatric Cardiac Genomics Consortium (PCGC). We identified rare (minor allele frequency &lt;1 × 10−4), de novo variants to ascertain pathways and processes affected in this population to better understand TOF pathogenesis. Pathways and biological processes enriched in the PCGC TOF cohort were compared to 317 controls without heart defects (and their parents) from the Simons Foundation Autism Research Initiative (SFARI).ResultsA total of 120 variants in 117 genes were identified as most likely to be deleterious, with CHD7, CLUH, UNC13C, and WASHC5 identified in two probands each. Gene ontology analyses of these variants using multiple bioinformatic tools demonstrated significant enrichment in processes including cell cycle progression, chromatin remodeling, myocyte contraction and calcium transport, and development of the ventricular septum and ventricle. There was also a significant enrichment of target genes of SOX9, which is critical in second heart field development and whose loss results in membranous ventricular septal defects related to disruption of the proximal outlet septum. None of these processes was significantly enriched in the SFARI control cohort.ConclusionInnate molecular defects in cardiac progenitor cells and genes related to their viability and contractile function appear central to non-syndromic TOF pathogenesis. Future research utilizing our results is likely to have significant implications in stratification of TOF patients and delivery of personalized clinical care.
Effect of physical activity and different exercise modalities on glycemic control in people with prediabetes: a systematic review and meta-analysis of randomized controlled trials
Authors: Bennasar-Veny Miquel , Malih Narges , Galmes-Panades Aina M. , Hernandez-Bermudez Ivonne C. , Garcia-Coll Natalia , Ricci-Cabello Ignacio , Yañez Aina M. 
Published: September 2023

BackgroundNumerous studies have shown the beneficial effects of exercise on glycemic control in people with prediabetes. However, the most effective exercise modality for improving glycemic control remains unclear. We aimed to assess which exercise training modality is most effective in improving glycemic control in a population with prediabetes.MethodsWe conducted searches in Pubmed/MEDLINE, EMBASE, SPORTDiscus, Web of Science, PEDro, BVS, and the Cochrane Library from inception to June 2022. Included studies reported fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and 2-hour postprandial (2hPP) levels and implemented an exercise program lasting at least 12 weeks in adults with prediabetes. We performed a direct meta-analysis using a random-effects model and a network meta-analysis. Cochran’s Q statistic and the inconsistency I2 test were used to assess the heterogenicity between studies.ResultsTwenty trials were included, with 15 trials (comprising 775 participants with prediabetes) combined in the meta-analysis, and 13 in the network meta-analysis. The meta-analysis results did not show a statistically significant reduction in fasting plasma glucose (FPG) after aerobic training (AT) intervention compared to a control group (mean (95%CI) difference = -5.18 (-13.48; 3.12) mg/dL, Z=1.22, p=0.22). However, a difference of -7.25 (-13.79; -0.71) mg/dL, p=0.03, in FPG after interval training (IT) intervention was detected compared to a control group. After resistance training (RT) intervention, FPG was significantly lower -6.71 (-12.65,-0.77) mg/dL, Z=2.21, p=0.03, and HbA1c by -0.13 (-0.55, 0.29), p=0.54, compared to the control group. The impact of RT compared to no intervention on 2hPP was not statistically significant (p=0.26). The network meta-analysis did not show statistical significance. Most of the studies presented an unclear risk of bias, and a low and very low-quality of evidence. According to the GRADE criteria, the strength of the body of evidence was low.ConclusionResistance training and IT had demonstrated benefits on glycemic indices, especially on FPG, in a population with prediabetes. Further studies with larger sample sizes and a more robust methodology that compare different types of exercise modalities, frequencies, and durations, are needed to establish a beneficial exercise intervention.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=370688, identifier CRD42022370688.
Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review
Authors: Li Honglin , Zhang Lei , Yang Feiran , Zhao Ruohan , Li Xiurong , Li Huijie 
Published: September 2023

IntroductionCancer is a major global health concern, and immune checkpoint inhibitors (ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can be influenced by various factors, including the use of concomitant medications.MethodsWe searched databases (PubMed, Embase, Cochrane Library, Web of Science) for systematic reviews and meta-analyses for systematic reviews and meta-analyses on the impact of concomitant medications on ICIs efficacy, published from inception to January 1, 2023. We evaluated the methodological quality of the included meta-analyses, and re-synthesized data using a random-effects model and evidence stratification.ResultsWe included 23 publications, comprising 11 concomitant medications and 112 associations. Class II-IV evidence suggested that antibiotics have a negative impact on ICIs efficacy. However, ICIs efficacy against melanoma, hepatocellular carcinoma, and esophageal squamous cell carcinoma was not affected, this effect was related to the exposure window (class IV). Class III evidence suggested that proton pump inhibitors have a negative impact on ICIs efficacy; nevertheless, the efficacy against melanoma and renal cell carcinoma was not affected, and the effect was related to exposure before the initiation of ICIs therapy (class II). Although class II/III evidence suggested that steroids have a negative impact, this effect was not observed when used for non-cancer indications and immune-related adverse events (class IV). Class IV evidence suggested that opioids reduce ICIs efficacy, whereas statins and probiotics may improve ICIs efficacy. ICIs efficacy was not affected by histamine 2 receptor antagonists, aspirin, metformin, β-blockers, and nonsteroidal anti-inflammatory agents.ConclusionCurrent evidence suggests that the use of antibiotics, PPIs, steroids, and opioids has a negative impact on the efficacy of ICIs. However, this effect may vary depending on the type of tumor, the timing of exposure, and the intended application. Weak evidence suggests that statins and probiotics may enhance the efficacy of ICIs. Aspirin, metformin, β-blockers, and NSAIDs do not appear to affect the efficacy of ICIs. However, caution is advised in interpreting these results due to methodological limitations.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO,identifier, CRD42022328681.
Morbidity and mortality related to type II odontoid fractures in octogenarians undergoing surgery: a retrospective study with 5 year follow up
Authors: Lenga Pavlina , Gülec Gelo , Kiening Karl , Unterberg Andreas W. , Ishak Basem 
Published: September 2023

IntroductionThe prevalence of trauma is increasing in the geriatric population. The optimal therapy for type II odontoid fractures in the elderly is controversial. This study aims to assess the morbidity and mortality associated with odontoid fractures in octogenarians undergoing C1/C2 posterior screw fixation and describe the perioperative and post-operative complications and risk factors associated with mortality.Materials and methodsElectronic medical records from a single institution pertaining to the period between September 2005 and December 2020 were retrieved. Data on patient demographics, neurological conditions, surgical characteristics, complications, hospital course, and 90-day mortality were collected.ResultsOver a 16-year period, 60 patients aged ≥80 years diagnosed with type II odontoid fractures were enrolled in the study. The mean age was 85.0 ± 1.9 years. The mean Charlson Comorbidity Index (CCI) was &gt;6 indicating a poor baseline reserve (8.5 ± 1.9), while cardiovascular diseases were the most prevalent among comorbidities. The mean surgical duration was 217.5 ± 65.9 min, with a mean blood loss of 725.5 ± 275.7 mL. The in-hospital was 5–0% and the 90-day mortality rates increased at 10.0%. No revision surgery was needed in any of the cases. Intraoperative and post-operative X-ray and computed tomography (CT) imaging revealed correct screw placement. Proper alignment of the atlantoaxial spine and fusion could be achieved in all cases. The unique risk factors for mortality included the presence of comorbidities and the occurrence of post-operative complications.ConclusionThe complication and mortality rates associated with odontoid fractures in octogenarians are relatively high. However, the therapeutic goals in this population also include bone union and preservation of neurological status. Despite the often-high comorbidity rate, we still recommend that surgery should be considered in patients over 80 years. However, it is necessary to evaluate several approaches when treating such frail patients.
Inonotus obliquus polysaccharide are linear molecules that alter the abundance and composition of intestinal microbiota in Sprague Dawley rats
Authors: Liu Songqing , Zhou Wenjing , Deng Xin , Jiang Wei , Wang Yanping , Zhan Jiasui , Hu Binhong 
Published: September 2023

IntroductionThe macromolecular polysaccharide Inonotus obliquus polysaccharide (IOP) is composed of various monosaccharides, and it could modulate the composition and diversity of intestinal flora. However, its impact on the intestinal flora in rats of different genders remains unclear. Therefore, this study aims to investigate the structural changes of IOP and its effects on the intestinal flora after administration in male and female rats.MethodsIn this study, the molecular weight and purity of IOP were analyzed by high-performance gel permeation chromatography (HPGPC) and phenol sulfuric acid method, and NMR was used to confirm the chemical structure of IOP. Sex hormone [testosterone (T) and estradiol (E2)] levels and intestinal microbial changes were detected by enzyme-linked immunosorbent assay (ELISA) and 16S rRNA, respectively, after gavage of IOP (100 mg/kg) in male and female Sprague Dawley (SD) rats.ResultsHPGPC analysis showed that the average molecular weight (Mw) of IOP was 4,828  Da, and the total sugar content of the purified IOP was 96.2%, indicating that the polysaccharide is of high purity. NMR revealed that IOP is a linear macromolecule with an α-D-type glucose backbone. The results of ELISA and 16S rRNA showed that the IOP increased the abundance of beneficial bacteria, such as Clostridia_UCG-014 and Prevotellaceae_NK3B31, and reduced that of harmful bacteria, such as Colidextribacter and Desulfobacterota in the intestine of both male and female rats, and IOP changed the levels of sex hormones in male and female rats. Further analyses revealed that the increase in alpha diversity was higher in male than female rats. α diversity and β diversity revealed a significant difference in the composition of cecal microbiota between male and female rats in the control group, but IOP intake reduced this difference. Meanwhile, α analysis revealed a change in the composition of bacterial flora was more stable in male than female rats.ConclusionsThis study enhances our comprehension of the IOP structure and elucidates the alterations in intestinal flora following IOP administration in rats of varying genders. Nonetheless, further investigation is warranted to explore the specific underlying reasons for these discrepancies.