bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma
Authors: Mandelker Diana , Marra Antonio , Zheng-Lin Binbin , Selenica Pier , Blanco-Heredia Juan , Zhu Yingjie , Gazzo Andrea , Wong Donna , Yelskaya Zarina , Rai Vikas , Somar Joshua , Ostafi Silvana , Mehta Nikita , Yang Ciyu , Li Yirong , Brown David N. , da Silva Edaise M. , Pei Xin , Linkov Irina , Terraf Panieh , Misyura Maksym , Ceyhan-Birsoy Ozge , Ladanyi Marc , Berger Michael , Pareja Fresia , Stadler Zsofia , Offit Kenneth , Riaz Nadeem , Park Wungki , Chou Joanne , Capanu Marinela , Koehler Maria , Rosen Ezra , O'Reilly Eileen M. , Reis-Filho Jorge S. 
Published: August 2023

PURPOSE To determine the genetic predisposition underlying pancreatic acinar cell carcinoma (PACC) and characterize its genomic features. METHODS Both somatic and germline analyses were performed using an Food and Drug Administration–authorized matched tumor/normal sequencing assay on a clinical cohort of 28,780 patients with cancer, 49 of whom were diagnosed with PACC. For a subset of PACCs, whole-genome sequencing (WGS; n = 12) and RNA sequencing (n = 6) were performed. RESULTS Eighteen of 49 (36.7%) PACCs harbored germline pathogenic variants in homologous recombination (HR) and DNA damage response (DDR) genes, including BRCA1 (n = 1), BRCA2 (n = 12), PALB2 (n = 2), ATM (n = 2), and CHEK2 (n = 1). Thirty-one PACCs displayed pure, and 18 PACCs harbored mixed acinar cell histology. Fifteen of 31 (48%) pure PACCs harbored a germline pathogenic variant affecting HR-/DDR-related genes. BRCA2 germline pathogenic variants (11 of 31, 35%) were significantly more frequent in pure PACCs than in pancreatic adenocarcinoma (86 of 2,739, 3.1%; P < .001), high-grade serous ovarian carcinoma (67 of 1,318, 5.1%; P < .001), prostate cancer (116 of 3,401, 3.4%; P < .001), and breast cancer (79 of 3,196, 2.5%; P < .001). Genomic features of HR deficiency (HRD) were detected in 7 of 12 PACCs undergoing WGS, including 100% (n = 6) of PACCs with germline HR-related pathogenic mutations and 1 of 6 PACCs lacking known pathogenic alterations in HR-related genes. Exploratory analyses revealed that in PACCs, the repertoire of somatic driver genetic alterations and the load of neoantigens with high binding affinity varied according to the presence of germline pathogenic alterations affecting HR-/DDR-related genes and/or HRD. CONCLUSION In a large pan-cancer cohort, PACC was identified as the cancer type with the highest prevalence of both BRCA2 germline pathogenic variants and genomic features of HRD, suggesting that PACC should be considered as part of the spectrum of BRCA-related malignancies.
The road to success: drawing parallels between 'road' and 'research data' infrastructures to foster understanding between service providers, funders and policymakers
Authors: Hooft Rob W.W. , Harrison Elaine , Martin Corinne S. 
Published: August 2023

Background: The work of data research infrastructure operators is poorly understood, yet the services they provide are used by millions of scientists across the planet. Policy and implications: As the data services and the underlying infrastructure are typically funded through the public purse, it is essential that policymakers, research funders, experts reviewing funding proposals, and possibly even end-users are equipped with a good understanding of the daily tasks of service providers. Recommendations: We suggest drawing parallels between research data infrastructure and road infrastructure. To trigger the imagination and foster understanding, this policy brief contains a table of corresponding aspects of the two classes of infrastructure, and a table of policy implications. Conclusions: Just as economists and specialist evaluators are typically brought in to inform policies and funding decisions for road infrastructure, we encourage this to also be done for research infrastructures
“The person was like the glue in the cracked pot which was no longer there”: Family-focused support for bereavement via co-production of a web-based intervention
Authors: Campling Natasha , Lund Susi , Allam Alison , Precious Gail , Myall Michelle 
Published: August 2023

Background: Families, friends and support networks are key to managing bereavement. COVID-19 social restrictions prevented families and friends from being with the dying and participating in usual rituals to honour the dead. This resulted in social disconnection, feelings of guilt, and difficulty in making sense of the death and reconstructing relationships. In response to this context a theoretically informed, co-produced web-resource to facilitate meaning-making, which situates bereavement in the context of family and friends, was developed. This paper describes the development of the web-based intervention. Study aims: To co-produce a web-based intervention theoretically informed by the family level extension Dual Process Model and Family Sense of Coherence, and pilot the intervention gaining user feedback to inform refinements in readiness for adoption and implementation. Methods: Following a scoping review, a mixed methods study was undertaken using an online survey via questionnaire and virtual co-production workshop with bereaved people and bereavement professionals. Results: Survey respondents reported the pandemic negatively affected bereavement (guilt, isolation, inability to bear witness) but also presented new opportunities to celebrate the deceased and support the bereaved (new funeral rituals, technology, remote contact, social acknowledgement of grief). Sense-making and managing bereavement were helped through information-giving, support networks, and relocating the person within the family context. A web-resource to facilitate collective grief was viewed positively and endorsed. Key content including family activities to stimulate support, information regarding the range of grief experience and dealing with the practicalities, along with other sources of support was agreed by workshop participants to form the basis of the intervention. Conclusion: The Families in Bereavement intervention encourages consideration of bereavement in the context of close social networks. It enables grief to be understood and managed within a shared experience by promoting communication and meaning-making.
Solving Strong-Substitutes Product-Mix Auctions
Authors: Baldwin Elizabeth , Goldberg Paul W. , Klemperer Paul , Lock Edwin 
Published: August 2023

This paper develops algorithms to solve strong-substitutes product-mix auctions: it finds competitive equilibrium prices and quantities for agents who use this auction’s bidding language to truthfully express their strong-substitutes preferences over an arbitrary number of goods, each of which is available in multiple discrete units. Our use of the bidding language and the information it provides contrasts with existing algorithms that rely on access to a valuation or demand oracle. We compute market-clearing prices using algorithms that apply existing submodular minimization methods. Allocating the supply among the bidders at these prices then requires solving a novel constrained matching problem. Our algorithm iteratively simplifies the allocation problem, perturbing bids and prices in a way that resolves tie-breaking choices created by bids that can be accepted on more than one good. We provide practical running time bounds on both price finding and allocation and illustrate experimentally that our allocation mechanism is practical. Funding: E. Baldwin and P. Klemperer were supported by the Economic and Social Research Council [Grant ES/L003058/1]. P. W. Goldberg and E. Lock were supported by a JP Morgan faculty fellowship during the work on the final version of the paper. Supplemental Material: The online companion is available at https://doi.org/10.1287/moor.2019.0248 .
A Contextual Ranking and Selection Method for Personalized Medicine
Authors: Du Jianzhong , Gao Siyang , Chen Chun-Hung 
Published: August 2023

Problem definition: Personalized medicine (PM) seeks the best treatment for each patient among a set of available treatment methods. Because a specific treatment does not work well on all patients, traditionally, the best treatment was selected based on the doctor’s personal experience and expertise, which is subject to human errors. In the meantime, stochastic models have been well developed in the literature for a lot of major diseases. This gives rise to a simulation-based solution for PM, which uses the simulation tool to evaluate the performance for pairs of treatment and patient biometric characteristics and, based on that, selects the best treatment for each patient characteristic. Methodology/results: In this research, we extend the ranking and selection (R&S) model in simulation-based decision making to solving PM. The biometric characteristics of a patient are treated as a context for R&S, and we call it contextual ranking and selection (CR&S). We consider two formulations of CR&S with small and large context spaces, respectively, and develop new techniques for solving them and identifying the rate-optimal budget allocation rules. Based on them, two selection algorithms are proposed, which can be shown to be numerically superior via a set of tests on abstract and real-world examples. Managerial implications: This research provides a systematic way of conducting simulation-based decision-making for PM. To improve the overall decision quality for the possible contexts, more simulation efforts should be devoted to contexts in which it is difficult to distinguish between the best treatment and non-best treatments, and our results quantify the optimal trade-off of the simulation efforts between the pairs of contexts and treatments. Funding: J. Du is partially supported by the National Natural Science Foundation of China [Grant 72091211]. C.-H. Chen is partially supported by the National Science Foundation under Awards FAIN212368. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.0232 .
Adversarial Robustness for Latent Models: Revisiting the Robust-Standard Accuracies Tradeoff
Authors: Javanmard Adel , Mehrabi Mohammad 
Published: August 2023

Low-dimensional structure of data can solve the adversarial robustness-accuracy conflict for machine learning systems. Modern machine learning systems have demonstrated breakthrough performance in a multitude of applications. However, they are known to be highly vulnerable to small perturbations to the input data, known as adversarial attacks. There are many well-documented examples of such behavior, for example small perturbations of an image, which is imperceptible to a human, can significantly degrade performance of modern classifiers. Adversarial training has been put forward as a way to improve robustness of learning algorithms to adversarial attacks. However, this benefit often comes at the cost of decreasing accuracy on natural unperturbed inputs, pointing to a potential conflict between adversarial robustness and standard accuracy. In “Adversarial robustness for latent models: Revisiting the robust-standard accuracies tradeoff,” Adel Javanmard and Mohammad Mehrabi develop a theory to show that when the data enjoys low-dimensional structure, then it is possible to train models that are nearly optimal with respect to both, the standard and robust accuracies.
Analysis of Future Prospects and Opportunities for Wood Adhesives: A Review*
Authors: Hunt Christopher G. , Dunky Manfred 
Published: August 2023

Abstract
This paper addresses strengths, weaknesses, opportunities, and threats of the wood adhesives industry as discussed at the International Conference on Wood Adhesives in May 2022. The authors have organized the points made during the discussion and added further facts, assumptions, and conclusions to provide context and perspective, even surpassing the outcome of the discussion. The biggest themes of the discussion were the unprecedented opportunity for adhesives to enable forest products to supply society's surging demand for renewable materials and the challenges in meeting those demands. We see excellent opportunities for wood-based panels and with this, for wood adhesives. The abundant challenges to bio-based adhesives for wood products are highlighted by the large amount of research and commercial effort compared with the small volumes of bio-based adhesives in use. Other threats to the adhesive and bonded products industries include aversion to any chemicals (even stable adhesives), and lack of experienced work force. Wood adhesives underwent significant changes in the past decades, mainly focused on reducing emissions during panel use. Wood use in construction will be boosted by efforts to fulfil the European Green Deal, as implemented in the New European Bauhaus and European Renovation Wave.
Sodium carbonate modulated ultrashort mode-locked stretched pulses in an erbium-doped fiber laser
Authors: Najm Mustafa Mohammed , Zhang Pei , Al-Azzawi Alabbas A. , Abdullah Mohammed Najm , Yasin Moh , Harun Sulaiman Wadi 
Published: August 2023

In this paper, we propose a new, to the best of our knowledge, saturable absorber (SA)
based on sodium carbonate (Na2CO3) for producing an ultrafast
mode-locked stretched pulse in a passively erbium-doped fiber laser at
near-zero dispersion. The solid film of a Na2CO3-SA was fabricated by the drop-casting
method using polyvinyl alcohol as a host polymer. The modulation depth
of the proposed SA, which was measured by a balanced twin detector
technique, was 2.3% with saturation intensity of 181MW/cm2. The mode-locking operation of the
EDFL-based Na2CO3-SA was observed at a pump power of
117 mW. A stable stretched pulse was generated by using the
proposed Na2CO3-SA. The laser can generate pulses
with a repetition rate and duration of 1.87 MHz and
820 fs, respectively, within a bandwidth of 6.6 nm. The
single pulse energy reaches up to 5 nJ, which is equivalent to
the average output power of 9.3 mW. Finally, to the best of our
knowledge, this is the first report on using the Na2CO3-SA for generating a stretched-pulse
mode-locked fiber laser.
Mensch-Roboter-Zusammenarbeit in der Intralogistik: Vorteile und Auswirkungen auf die Beschäftigten
Authors: Zhang Minqi , Ludwig Michael G. , Grosse Eric H. 
Published: August 2023

ZusammenfassungDie Kommissionierung ist eine besonders zeit- und kostenintensive Tätigkeit in der Intralogistik, vor allem wenn diese manuell ausgeführt wird. Deswegen kann es für Unternehmen wirtschaftlich interessant sein, autonome Kommissionierroboter, die mit Menschen zusammenarbeiten, in einem hybriden System einzusetzen. Dieser Artikel gibt einen Überblick über die Vorteile der Mensch-Roboter-Zusammenarbeit in der Intralogistik und quantifiziert diese exemplarisch mit Hilfe eines Simulationsmodells. Daneben werden praxisnahe Herausforderungen bei der Implementierung derartiger hybrider Systeme in Bezug auf Menschenzentrierung, Ergonomie, Technologie-Akzeptanz und wirtschaftliche Arbeitsleistung im Sinne der Industrie 5.0 beleuchtet.
Analyse der Rolle Künstlicher Intelligenz für eine menschenzentrierte Industrie 5.0
Authors: Schmalzried Dirk , Hurst Marco , Wentzien Marcel , Gräser Max 
Published: August 2023

ZusammenfassungDie Künstliche Intelligenz ist eine bedeutende Technologie für Industrie 4.0. Sie trägt in vielen Bereichen zu Disruptionen bei. Die Nummerierung der „Industrie x.0“-Begriffe bezeichnete in der Vergangenheit disruptive Sprünge (sog. „Revolutionen“). Die aktuell für „Industrie 5.0“ vorgeschlagenen Kernelemente Menschenzentrierung, Resilienz und Nachhaltigkeit sind für sich genommen bereits im „Industrie‑4.0‑Kontext“ zentral und bezüglich ihrer Disruption diskutabel. Dieser Artikel erörtert, welche Rolle die Künstliche Intelligenz voraussichtlich in Industrie 5.0 spielen wird, insbesondere in Bezug auf das Kernelement „Menschenzentrierung“. Dazu wird der Stand der Technik zur Anwendung von künstlicher Intelligenz in Industrie 4.0 systematisiert und vorgestellt. Zu erwartende Veränderungen werden ausgehend von absehbar verfügbaren Technologien beschrieben. Die betrachteten Technologien sind Edge-AI, Metaversum, Robotik sowie erklärbare und vertrauenswürdige künstliche Intelligenz. Insgesamt kommen die Autoren zu dem Schluss, dass der Einfluss der künstlichen Intelligenz tatsächlich einen ganzen Nummernsprung rechtfertigen kann.
Characterization of 14 Triticum species for the NAM-B1 gene and its associated traits
Authors: Shoormij Fatemeh , Mirlohi Aghafakhr , Chan-Rodriguez David , Bolibok-Brągoszewska Hanna , Saeidi Ghodratollah 
Published: August 2023

Background
Wheat grain protein, zinc (Zn), and iron (Fe) content are important wheat qualities crucial for human nutrition and health worldwide. Increasing these three components simultaneously in wheat grains by a single gene came into the picture through NAM-B1 cloning. NAM-B1 gene and its association with the mentioned grain quality traits have been primarily studied in common and durum wheat and their progenitors T. dicoccum and T. dicoccoides.

Method
In the present study, for the first time, 38 wheat accessions comprising ten hexaploids from five species and 28 tetraploids from nine species were evaluated in the field for two consecutive years. Additionally, the 582 first nucleotides of the NAM-B1 gene were examined.

Result
The NAM-B1 gene was present in 21 tetraploids and five hexaploid accessions. Seven tetraploid accessions contained the wild-type allele (five T. dicoccum, one T. dicoccoides, and one T. ispahanicum) and fourteen the mutated allele with a ‘T’ insertion at position 11 in the open reading frame, causing a frameshift. In hexaploid wheat comprising the gene, only one accession of T. spelta contained the wild-type allele, and the rest resembled the insertion mutated type. In the two-year field experiment, eight accessions with the wild-type NAM-B1 allele had significantly higher protein, Zn and Fe grain content when compared to indel-type accessions. Additionally, these accessions exhibited a lower mean for seed-filling duration than all other accessions containing indel-type alleles. In terms of grain yield, 1,000-kernel weight, kernel diameter, and kernel length, T. dicoccum accessions having wild-type alleles were similar to the indel-type accessions over two years of evaluation.

Conclusion
These findings further support the possibility of simultaneous improvement of wheat grain protein, Zn, and Fe content by a single gene crucial for human nutrition and health worldwide.
Factors related to subjective well-being among community-dwelling older adults living alone: A stratified analysis by sex and marital status from the JAGES
Authors: Abe Nana , Oe Nanami , Tadaka Etsuko , Ojima Toshiyuki 
Published: August 2023

Background
Previous cross-sectional studies suggest that negative health outcomes such as mortality, social isolation, loneliness, and depression among older adults living alone vary by sex and marital status, with men often worse off than women and unmarried people worse off than married people. However, limited evidence exists from longitudinal studies regarding whether positive health outcomes such as subjective well-being (SWB) also vary by sex and marital status. The focus by sex and marital status on the positive health outcomes and diverse profiles of older adults living alone is important for public health in the near future. Therefore, the purpose of this study was to identify changes in SWB over time and its associated factors by sex and marital status among older adults living alone in the community using a longitudinal study in a representative population.

Methods
This was a longitudinal study using data from the Japan Gerontological Evaluation Study. This study is the first to reveal differences in SWB and related factors over 3 years among older adults living alone in the community (n = 8,579) who were stratified by sex and marital status (married men, non-married men, married women, and non-married women).

Results
Women moved to higher levels of SWB than did men, and married individuals moved to higher levels of SWB than did unmarried individuals. Independent functioning factors and interpersonal factors were significantly associated with SWB for married men and married women, but for unmarried women, the association by interpersonal factors was more pronounced, and for unmarried men, only limited emotional support and health promotion activities were significant among the interpersonal factors.

Conclusions
This study revealed that among older adults living alone, changes in SWB over time and the independent functioning factors and interpersonal factors associated with this change varied by sex and marital status among older people living alone. These findings are useful for policy-making and guiding intervention activities to promote SWB in a society in which the environment for older adults living alone is changing dramatically.
Ways into physical (in)activity: The role of critical life events and transitions in the reconstructions of young adults
Authors: Gropper Hannes , John Jannika M. , Thiel Ansgar 
Published: August 2023

Background
Physical activity (PA), sport, and exercise levels generally tend to fluctuate or decline from childhood to adulthood. Life events and transitions may have a positive or negative impact on these behaviors. However, most research in this regard is quantitatively framed and we know little about why and how life events and transitions affect PA-related behaviors.

Objectives
The aim of this study is to understand when, why, and how individuals change their daily PA, sport, and exercise behaviors and related attitudes in the context of life events and transitions and what underlying dynamics promote these changes from a subjective perspective.

Methods
Forty-six young inactive adults (33 women) aged between 20 and 40 years from the iReAct study participated in a mixed-method biographical mapping, which combines a semi-structured interview with a drawing activity to explore subjective experiences of life events, transitions, and PA-related behaviors across the life span. To analyze data, we conducted a reflexive thematic analysis.

Results
We developed three overarching themes that reflect the underlying dynamics which are associated with the occurrence of critical life events and transitions and lead to subsequent changes in daily PA and sport and exercise behavior: (1) The finitude of temporal resources; (2) The plasticity of priorities and motives; and (3) The (in)conveniences of context.

Conclusion
Our results illustrate that there is not a straight causal link between life events and behavior. Rather, critical life events and transitions can have a tremendous impact on temporal resources, individual priorities and motives, and contextual factors, such as the physical and infrastructural environment and social settings and relationships. Consequently, more or less extensive changes in those circumstances can lead to individual adaptations in daily PA or sport and exercise and related attitudes, as they require individuals to re-balance behavioral patterns.