bluuebunny/crossref_metadata_2025_split huggingface dataset:
A role for Toll-like receptor 3 in lung vascular remodeling associated with SARS-CoV-2 infection
Authors: Farkas Daniela , Bogamuwa Srimathi , Piper Bryce , Newcomb Geoffrey , Gunturu Pranav , Bednash Joseph S. , Londino James D. , Elhance Ajit , Nho Richard , Mejia Oscar Rosas , Yount Jacob S. , Horowitz Jeffrey C. , Goncharova Elena A. , Mallampalli Rama K. , Robinson Richard T. , Farkas Laszlo 
Published: January 2023

ABSTRACTCardiovascular sequelae of severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) disease 2019 (COVID-19) contribute to the complications of the disease. One potential complication is lung vascular remodeling, but the exact cause is still unknown. We hypothesized that endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2. In the lungs of COVID-19 patients and SARS-CoV-2 infected Syrian hamsters, we discovered thickening of the pulmonary artery media and microvascular rarefaction, which were associated with decreased TLR3 expression in lung tissue and pulmonary artery endothelial cells (ECs).In vitro, SARS-CoV-2 infection reduced endothelial TLR3 expression. Following infection with mouse-adapted (MA) SARS-CoV-2, TLR3 knockout mice displayed heightened pulmonary artery remodeling and endothelial apoptosis. Treatment with the TLR3 agonist polyinosinic:polycytidylic acid reduced lung tissue damage, lung vascular remodeling, and endothelial apoptosis associated with MA SARS-CoV-2 infection. In conclusion, repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection associated lung vascular remodeling and enhancing TLR3 signaling is a potential strategy for treatment.
Coronaviruses use ACE2 monomers as entry receptors
Authors: Eiring Patrick , Klein Teresa , Backes Simone , Streit Marcel , Doose Sören , Beliu Gerti , Sauer Markus 
Published: January 2023

AbstractThe angiotensin-converting enzyme 2 (ACE2) has been identified as entry receptor on cells enabling binding and infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via trimeric spike (S) proteins protruding from the viral surface1,2. It has been suggested that trimeric S proteins preferably bind to plasma membrane areas with high concentrations of preferably multimeric ACE2 receptors to achieve a higher binding and infection efficiency1,3. However, our current knowledge about the influence of ACE2 expression and organization in the plasma membrane on SARS-CoV-2 infection efficiency remains elusive. Here we useddirectstochastic optical reconstruction microscopy (dSTORM) in combination with different labeling approaches to visualize the distribution and quantify the expression of ACE2 on different cells. Our results reveal that endogenous ACE2 receptors are present as monomers in the plasma membrane with densities of only 1-2 receptors μm-2. In addition, binding of trimeric S proteins does not induce clustering of ACE2 receptors in the plasma membrane. Supported by infection studies using vesicular stomatitis virus (VSV) particles bearing S proteins our data demonstrate that a single S protein interaction per virus particle with a monomeric ACE2 receptor is sufficient for infection which attests SARS-CoV-2 a high infectivity.
A ROS-based hybrid algorithm for the UAV path planning problem
Authors: Canpolat Tosun Demet , Işık Yasemin 
Published: January 2023

Purpose
It is possible with classical path planning algorithms to plan a path in a static environment if the instant position of the vehicle is known and the target and obstacle positions are constant. In a dynamic case, these methods used for the static environment are insufficient. The purpose of this study is to find a new method that can provide a solution to the four-rotor unmanned aerial vehicle (UAV) path planning problem in static and dynamic environments.

Design/methodology/approach
As a solution to the problem within the scope of this study, there is a new hybrid method in which the global A* algorithm and local the VFH+ algorithm are combined.

Findings
The performance of the designed algorithm was tested in different environments using the Gazebo model of a real quadrotor and the robot operating system (ROS), which is the widely used platform for robotic applications. Navigation stacks developed for mobile robots on the ROS platform were also used for the UAV, and performance benchmarks were carried out. From the proposed hybrid algorithm, remarkable results were obtained in terms of both planning and implementation time compared to ROS navigation stacks.

Originality/value
This study proposes a new hybrid approach to the path planning problem for UAVs operating in both static and dynamic environments.
The role of purchasing in raising the maturity of smart maintenance management
Authors: Johannes Koos , Voordijk Hans , Aranda-Mena Guillermo 
Published: January 2023

PurposeThe aim of this study is to provide insights into how the purchasing function can increase the maturity of smart maintenance management (SMM) in construction clients by (1) assessing current SMM maturity and (2) developing an adapted service triad for purchasing's meaningful involvement in SMM.Design/methodology/approachA multiple case research design was used, and data were collected from four higher education institutes in the Netherlands through an assessment of their current SMM maturity. Coding and a cross-case analysis were used to qualitatively analyze the data to identify roles and value chain integration factors as intermediate steps in adapting the service triad to a service hexad.FindingsWithin construction client organizations, collaboration between maintenance management, project management and ICT services requires improvement. The proposed service hexad redefines the client's SMM roles with the aim of improving collaboration. The authors discuss how this enables a transition to higher levels of SMM maturity.Research limitations/implicationsThe findings were derived from a particular class of construction clients: higher education institutes that operate owner-occupied properties. Although the service hexad could be adapted, to owner-occupied multi-user properties, further research is necessary to assess its relevance for investor-owned properties.Practical implicationsImplementing the service hexad provides construction clients with a stronger position in supply networks. It clarifies the briefing process in construction management and emphasizes the data supply responsibilities of construction management professionals.Originality/valueThe study draws on the service triads and meaningful involvement concepts from the purchasing literature and applies them to SMM.
ABEE: automated bio entity extraction from biomedical text documents
Authors: Kumar Ashutosh , Sharaff Aakanksha 
Published: January 2023

PurposeThe purpose of this study was to design a multitask learning model so that biomedical entities can be extracted without having any ambiguity from biomedical texts.Design/methodology/approachIn the proposed automated bio entity extraction (ABEE) model, a multitask learning model has been introduced with the combination of single-task learning models. Our model used Bidirectional Encoder Representations from Transformers to train the single-task learning model. Then combined model's outputs so that we can find the verity of entities from biomedical text.FindingsThe proposed ABEE model targeted unique gene/protein, chemical and disease entities from the biomedical text. The finding is more important in terms of biomedical research like drug finding and clinical trials. This research aids not only to reduce the effort of the researcher but also to reduce the cost of new drug discoveries and new treatments.Research limitations/implicationsAs such, there are no limitations with the model, but the research team plans to test the model with gigabyte of data and establish a knowledge graph so that researchers can easily estimate the entities of similar groups.Practical implicationsAs far as the practical implication concerned, the ABEE model will be helpful in various natural language processing task as in information extraction (IE), it plays an important role in the biomedical named entity recognition and biomedical relation extraction and also in the information retrieval task like literature-based knowledge discovery.Social implicationsDuring the COVID-19 pandemic, the demands for this type of our work increased because of the increase in the clinical trials at that time. If this type of research has been introduced previously, then it would have reduced the time and effort for new drug discoveries in this area.Originality/valueIn this work we proposed a novel multitask learning model that is capable to extract biomedical entities from the biomedical text without any ambiguity. The proposed model achieved state-of-the-art performance in terms of precision, recall and F1 score.
Taking action in the first five years to increase career equality: the impact of professional relationships on young women’s advancement
Authors: Olsen Katie , LaGree Danielle 
Published: January 2023

Purpose
The purpose of this paper is to examine how young women understand and make meaning of their status as early-career women (ECW) in the creative communication industry, which is typically dominated by male leadership. It explores how professional relationships influence their transition into full-time employment and influences their career trajectories.

Design/methodology/approach
Interviews with 31 women in the first five years of their communication careers provided insights into how they experience professional relationships in the workplace in relation to leadership advancement. Inductive coding, a feminist organizational communication lens and literature on mentorship and role modeling was used to explore the standpoint of these young women.

Findings
Young women understand that professional relationships are necessary for acclimation and professional development. Our analysis revealed an intersection of three distinct ways these relationships help young women cultivate a strong career foundation, positioning themselves for leadership opportunities.

Practical implications
This study provides insight into the experiences of ECW, a group significantly overlooked by industry and research as a way to increase career equity. Findings from this study guide programmatic and socialization practices to help young women overcome barriers.

Originality/value
Developing a deeper understanding of women worker’s realities, this research encourages industries to regard the entire career path, emphasizing the importance of beginning socialization experiences in the workplace. It offers actionable managerial practices, and it drives a new scholarly focus on a demographic critical to closing the leadership gender gap.
Productivity and real exchange rates for India: does Balassa-Samuelson effect explain?
Authors: Ghosh Saurabh , Nath Siddhartha , Srivastava Sauhard 
Published: January 2023

PurposeThis study aims to explore the long-run equilibrium relationship between India’s real exchange rate and sectoral productivity trends using internationally comparable KLEMS databases on productivity for India, China, Euro area, the USA, the UK and Japan.Design/methodology/approachThis study uses pooled mean group estimations for panel data suggested by Pesaranet al.(1999). This method is chosen because of the presence of variables with different orders of integration.FindingsThe results find support for an “extended” Balassa–Samuelson (BS) hypothesis which allows labour market frictions that does not allow for wage equalisation between traded and non-traded sectors within a country. This mechanism continues to find some support when we separate out distribution sector that comprises wholesale and retail trade in the domestic services sector. The empirical evidence suggests that India’s real exchange rate is anchored to domestic fundamentals and is closely aligned to its fair value over a medium to long-time horizon.Originality/valueTo the best of the authors’ knowledge, unlike the available literature, which uses aggregate per-capita income as proxy for a country’s productivity growth, this paper perhaps makes the first attempt to validate the BS hypothesis by accounting for productivity differential at the sectoral levels using KLEMS data across countries. Moreover, this study takes the country’s productivity improvement rather than using a basket of countries, a prevalent practice in the literature. While this paper uses India’s data, which witnessed a prolonged appreciation in its real effective exchange rate and rapid technological progress, the authors believe its findings and policy implications could be applicable to the similar emerging market economies.
A critical reflection on digitalization for the hospitality and tourism industry: value implications for stakeholders
Authors: Ozdemir Ozgur , Dogru Tarik , Kizildag Murat , Erkmen Ezgi 
Published: January 2023

Purpose
This study aims to critically review the emerging technological developments and digitalization efforts in the hospitality and tourism (HT) industry and discuss the implications of digitalization on various stakeholders (e.g. consumers, employees, companies and operators) with reference to value creation.

Design/methodology/approach
This paper is a conceptual, critical reflection paper. Thus, the study reflects the authors’ assessment and reflection of the current digitalization efforts in the HT industry with a particular interest in value creation.

Findings
The study suggests that digitalization is still in its infancy state in terms of adoption and value creation in the HT industry. Yet, there are various opportunities for all stakeholders to benefit from existing and emerging digitalization applications.

Practical implications
This study can be used by industry professionals and scholarly researchers as a reflection of past and current digitalization efforts in the HT industry. Moreover, the study offers directions regarding the future digitalization movement in the HT industry and how such a movement might create important value propositions for various stakeholders.

Originality/value
The study is uniquely positioned as a critical reflection paper on the digitalization effort of the HT industry and offers new practical insights regarding how digitalization could create value for industry stakeholders as it finds more application areas. In this regard, it differs from prior review studies that focused solely on the use of new and emerging technologies in HT operations.
Do managers’ negotiation styles make employees’ relational justice-emotional experiences links sporadic?
Authors: Iqbal Muhammad Zahid , Shakoor Ayesha , Ikramullah Malik , Khan Tamania 
Published: January 2023

Purpose
Being grounded in interdependence theory, this study aims to address the following research question: Do managers’ negotiation styles (collaborative versus competitive) make employees’ relational justice-emotional experiences links sporadic?

Design/methodology/approach
Data elicited from N = 139 Pakistani undergraduate students participating in an online scenario-based experiment were used to employ repeated measures analysis and partial least square structural equation modeling techniques.

Findings
Results suggest that employees’ relational justice is likely to be higher when managers use a collaborative negotiation style than when they use competitive style in performance review meetings. Moreover, per managers’ different negotiation styles, employees’ relational justice perceptions may predict their positive emotions differently. That is, when managers use collaborative negotiation style, employees’ relational justice perceptions may positively predict their hope but not optimism, whereas when managers use competitive negotiation style, employees’ relational justice perceptions may positively predict their optimism but not hope. Furthermore, the positive relationship between employees’ relational justice and their optimism is stronger when their trust in manager is low than when it is high.

Originality/value
The study is of value for performance management theorists who aim to address the issue of ineffectiveness of the practice through relational means. The study includes the recently explicated concept of relational justice and examines its links with employee emotional reactions to performance reviews. Moreover, the study unveils how managers’ negotiation styles in performance review meetings cause variations in the links between employees’ perceptions of relational justice and their emotional experiences.
COVID-19 phobia, response to the vaccine and the right of urban migrant dwellers in the Ghanaian slums
Authors: Agyabeng Anthony Nkrumah , Preko Alexander , Avusuglo Kofi Hilla , Kumasey Anthony Sumnaya , Kantanka Akwasi Sarfo , Feglo Mawuli 
Published: January 2023

Purpose
This study investigate urban migrant dwellers’ gender and age differences in response to the specific phobia of COVID-19 and hesitancy toward vaccines in the slum settlements.

Design/methodology/approach
The study anchored on the two-factor model proposed by Mowrer (1939) and used a quantitative design approach with a convenience sampling method for data gathering among 362 urban migrants residing and working in the cities of Ghana. The study used the Mann–Whitney U test and the regression analysis for the analysis.

Findings
The result showed that there is a significant difference between males and females in their understanding of economic phobia, thoughts on social phobia and perception level of vaccine hesitancy. Additionally, there is a significant difference between age groups in their level of thoughts of psychological phobia, economic phobia and thoughts of vaccine hesitancy. Finally, the specific of phobias of COVID-19 are significant predictors of vaccine hesitancy.

Research limitations/implications
This research is slum-specific, which implies that the outcome cannot be generalized to other geographical settings.

Practical implications
The study demonstrates how a pandemic manifests itself to dwellers in slums. The outcome of the study sheds light on how policymakers appreciate the dynamics of the pandemic in a developing country, which may guide future responses to pandemics.

Originality/value
The outcome of the study sheds light on how policymakers appreciate the dynamics of the pandemic in a developing country, which may guide future responses to pandemics.
Role of risk disclosure on creditworthiness and driving forces of risk disclosure of banks: Islamic vs conventional banks
Authors: Hasan Md. Bokhtiar , Raza Rabbani Mustafa , Sarker Tapan , Akter Tanzila , Hasan Shaikh Masrick 
Published: January 2023

Purpose
This study aims to examine the effect of risk disclosure (RD) on commercial banks’ credit rating (CR) in the context of Bangladesh. It also explores the factors influencing RD in both Islamic and conventional banks.

Design/methodology/approach
The sample includes 200 bank-year observations consisting of 20 commercial banks (15 conventional and 5 Islamic banks) from 2010 to 2019. The sample is further segregated into Islamic and conventional banks. Ordered logit and random effect ordinary least square models are used to analyze the data. Furthermore, the two-stage least squares approach is used to perform a robustness test.

Findings
This study shows that RD significantly positively impacts CR, with a stronger effect in Islamic banks than in conventional banks. This study also finds that banks’ age and leverage negatively influence CRs. Moreover, banks’ size and total capital have a positive and negative influence on CRs, respectively. This study also shows that the age of Islamic and conventional banks positively and negatively influences the RD scores, respectively. In contrast, the RD score of conventional banks is positively impacted by bank size.

Practical implications
By examining which variables substantially impact RD and, hence, CR scores, bank stakeholders may make better financing, investment and other policy decisions. Investors may choose stocks with a high level of RD in the annual reports as the earlier studies imply that higher RD enhances CR.

Originality/value
Only a few studies have examined the relationship between RD and CRs, while, to the best of the authors’ knowledge, this study is the maiden attempt in the Bangladesh context. This study also compares the link between Islamic and conventional banks.
Financial analysts’ personal values, perceived behavioural risk and investment decisions in evaluating CSR
Authors: Shahid Ahmad Usman , Tufail Hafiza Sobia , Ali Hafiz Yasir , Jonathan Joane 
Published: January 2023

Purpose
This paper aims to contribute to the corporate social responsibility (CSR) literature by providing holistic insights into financial analysts’ personal values, perceived behavioural risk and investment decisions relating to the social aspects of CSR. Specifically, this paper examines whether analysts’ personal values, such as religiosity, spirituality and social consciousness, influence their investment decisions relating to a highly profitable firm that is alleged of exploiting labour rights. This study also examines the mediating role of analysts’ perceived behavioural risk between personal values and investment decisions.

Design/methodology/approach
Data were collected, using a scenario-based survey, from 145 financial analysts at both public and private companies in Pakistan.

Findings
The results show that analysts’ values, including religiosity, spirituality and social consciousness, have a significant negative impact on their investment decisions. The results also demonstrate that perceived behavioural risk mediates the relationship between these values and investment decisions.

Practical implications
This study has implications for the globalised business world, regulators and researchers for incorporating personal and ethical values into risk and investment decision-making.

Originality/value
This study establishes the importance of analysts’ personal values in risky investment decision-making.