bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metformin versus levonorgestrel-releasing intrauterine system in the management of endometrial hyperplasia: a randomized clinical trial
Authors: Taha Omima T. , Abd-Elgelil Mohammed M. , Kishk Eman A. , Shaaban Mohammed , Khamees Rasha E. 
Published: August 2023

Abstract
Background
Endometrial hyperplasia is one of the common causes of bleeding in perimenopausal women. Variable treatment options aim to induce regression. The current study evaluated the regression rate of endometrial hyperplasia after treatment with levonorgestrel intrauterine system (LNG- IUS) versus Metformin.

Methods
This randomized clinical trial was conducted at the obstetrics and gynecology department of Suez Canal University hospital. We recruited women diagnosed with endometrial hyperplasia without atypia. Patients were allocated into two groups. Group one included patients treated with levonorgestrel-releasing intrauterine system and group two treated with Metformin. The rate of regression of hyperplasia in both groups after six months of intervention was the main outcome measure.

Results
Significant regression of hyperplasia was noted in the LNG-IUS group (96% versus 64%, p-value 0.009). There was a significant decrease in the endometrial thickness after treatment in both groups (17.65 ± 4.62 and 5.3 ± 2.01 in the LNG- IUS with a p-value < 0.001) (19.57 ± 6.84 and 11.22 ± 7.51 in the metformin group with a p-value < 0.001). Factors that correlated with the Δ endometrial thickness included parity in the LNG- IUS group (p-value 0.019) and age and BMI in the metformin group (p-value 0.043 and 0.004 respectively).

Conclusion
Metformin had a regressive effect on endometrial hyperplasia; however, it was not significant as that achieved with the levonorgestrel intrauterine system.

Trial registrations
PACTR201908498370196.
Date of registration: 21/8/2019.
Date of first patient enrollment: 25/8/2019.
URL: https://pactr.samrc.ac.za/Researcher/TrialRegister.aspx?TrialID=9335
Incidence of hearing loss in neonates at a secondary care hospital in North India—a pilot UNHS study
Authors: Rawat Vijay , Arora Rubeena , Singh Jitendra , Gupta Aradhana 
Published: August 2023

Abstract
Background
To evaluate the incidence of hearing loss in neonates in our secondary care hospital under pilot UNHS programme. To assess association between various risk factors and neonatal hearing loss.

Methods
Prospective, observational cohort study was done in a secondary level hospital in North India after ethical approval, for 1 year. Inclusion criteria are as follows: neonates born in hospital during study period, consenting to testing. Exclusion criteria are as follows: sick neonates, non-consenting parents. Neonates underwent TEOAE at 48 h of birth; those failing retested at 1 month. Neonates failing 2nd stage are tested after 3 months using BERA. Neonates were evaluated for the presence of maternal/neonatal high-risk factors.

Results
Out of 506 neonates, 143 passed 1st OAE screening, 363 were refer, and referral rate is 71.7%. A total of 341/345 neonates passed 2nd stage; 4 were diagnosed with hearing loss on BERA at 3 months. (18 neonates lost to follow-up, excluded from final cohort.) Overall incidence of hearing loss was 0.82%, 1.08% for males and 0.44% for females (p = 0.87, NS). One-hundred nine neonates were high risk (prematurity, 36; consanguinity, 4; caesarean section for relevant indications, 68; craniofacial abnormalities, 1). Incidence of hearing loss for high-risk group was 1.83% and 0.53% for well-born neonates (p = 0.19, NS).

Conclusion
Incidence of hearing loss in our district in North India is as follows: 8.2 per 1000 live births for well neonates, 18.3 per 1000 live births for high-risk neonates, and respective overall national incidence rates were 1.59 to 8.8 per 1000 and 7 to 49 per 1000. UNHS programmes must be implemented in all hospitals; protocol may be varied according to local population profile and resources available.
Induced polarization of clay-rich materials — Part 2: The effect of anisotropy
Authors: Revil André , Ghorbani Ahmad , Jougnot Damien , Yven Béatrice , Grgic Dragan , Bretaudeau Francois , Deparis Jacques 
Published: August 2023

The anisotropy in the complex conductivity of a clay-rock formation is investigated through laboratory and in situ measurements. Laboratory measurements have been conducted on four samples from two cores of the Callovo-Oxfordian Formation from the Paris Basin (France). This clay-rock formation is anisotropic with a well-defined bedding plane. Two of the cylindrical core samples are taken in the transverse direction with respect to the bedding plane, whereas two other core samples are taken in the in-plane direction. The complex conductivity spectra are performed in the frequency range of 20 mHz to 45 kHz and in a broad pore water saturation range from near saturation to a residual saturation of approximately 25%. The complex conductivity spectra are fitted with a double Cole-Cole model, whereas the low-frequency contribution corresponding to the induced polarization effect and the high-frequency contribution is related to the Maxwell-Wagner polarization. The six Cole-Cole parameters are investigated as a function of saturation, and we evaluate their degree of anisotropy versus the effect of saturation. The low-frequency instantaneous conductivity and normalized chargeability indicate a consistent degree of anisotropy with an anisotropy ratio equal to 3.8 ± 0.5 for one core sample and 6.5 ± 0.9 for the second core sample. These values represent a substantial level of anisotropy. The low-frequency Cole-Cole exponent and relaxation time do not indicate substantial amount of anisotropy. The monitoring of the evolution of the weight in the controlled humidity chamber seems to indicate that their relative permeabilities do not indicate a strong anisotropic behavior. Finally, the laboratory data are discussed in the context of field data obtained with an azimuthal array of 12 electrodes.
Information Technology and Telemedicine Services in Community Oncology Practices
Authors: Loh Kah Poh , Wang Ying , Yilmaz Sule , Nightingale Chandylen L. , Parsons Susan K. , Braun-Inglis Christa , Gada Umang , Montes Alexander , Magnuson Allison , Culakova Eva , Strause Sarah , Kamen Charles , Dressler Emily , Mustian Karen , Morrow Gary , Mohile Supriya ,   on behalf of the Landscape Committee, Neuman Heather B. , Nightingale Chandylen L. , Parsons Susan K. , Obeng-Gyasi Samilia , Cooley Mary E. , Loh Kah Poh , Ramsey Scott D. , McDonald Andrew M. , Foust Melyssa , Braun-Inglis Christa , Kyono Wade T. , Drescher Charles W. , Wood Eden G. , Dressler Emily V. 
Published: August 2023

PURPOSE We described information technology support and use of telemedicine for cancer care and research purposes at community oncology practices within the National Cancer Institute Community Oncology Research Program (NCORP). METHODS We used data from the NCORP 2017 and 2022 Landscape Assessments. Separate logistic regression models were used to assess factors associated with the use of telemedicine for delivery of cancer care in 2017 and for research purposes in 2022 (cancer care delivery not assessed in 2022). RESULTS Information was available from 210 and 259 practice groups excluding pediatric-only groups in 2017 and 2022, respectively. In 2017, 30% of practice groups used telemedicine for delivery of cancer care; half of these (15% overall) could use telemedicine for research purposes. In 2022, telemedicine was used for research purposes in 73% of practice groups. In multivariable models, self-identifying as a safety-net hospital was associated with a lower odd of telemedicine use for delivery of cancer care (adjusted odds ratio [AOR], 0.39; 95% CI, 0.17 to 0.93), whereas affiliation with a designated critical access hospital was associated with a higher odd of telemedicine use for delivery of cancer care (AOR, 2.29; 95% CI, 1.10 to 4.76). Having a general survivorship clinic (AOR, 1.92; 95% CI, 1.04 to 3.54) and number of oncology providers (increase per 10 providers; AOR, 1.32; 95% CI, 1.05 to 1.65) were associated with telemedicine use for research purposes. CONCLUSION Almost one third of NCORP practice groups used telemedicine for cancer care delivery in 2017. In 2022, there is high capacity among NCORP practices (almost three-quarters) to use telemedicine for research purposes, especially among practices with a general survivorship clinic and a greater provider number.
Safety, Feasibility, and Acceptability of a Multisite Individualized Exercise Intervention for People with Multiple Myeloma
Authors: Nicol Jennifer L. , Cunningham Brent J. , WOODROW CARMEL , ADLARD KIRSTEN N. , PAPINCZAK ZOE E. , SPENCE ROSALIND R. , BOYTAR ALEXANDER N. , MOLLEE PETER , WEBER NICHOLAS , NICOL ANDREW J. , HILL MICHELLE M. , SKINNER TINA L. 
Published: August 2023

ABSTRACT

Introduction
High rates of disease- and treatment-related symptoms, such as bone lesions, in people with multiple myeloma (MM) create uncertainty on the safety and feasibility of exercise. This study determined the safety, feasibility, and acceptability of an individualized exercise medicine program for people with MM at any disease stage.

Methods
A multisite, randomized waitlist-controlled trial was conducted of an individualized, high-intensity aerobic, resistance, and impact-loading exercise program. The exercise sessions were supervised twice weekly by accredited exercise physiologists, with one additional unsupervised session per week, for 12 wk. Safety was determined by number of adverse and serious adverse events. Feasibility outcome measures were study eligibility, recruitment, adherence, and attrition. Acceptability was determined by qualitative interviews and subjective levels of enjoyment.

Results
Of 203 people with MM screened, 88% were eligible, with 34% accepting participation (60 people) and 20% attrition for the between-group analysis, meeting a priori criteria (≥25% and <25%, respectively). No adverse or serious adverse events attributed to testing and/or exercise training were reported. Attendance at supervised exercise sessions was 98%, with 45% completion of the home-based exercise sessions. Adherence rates were 35%, 63%, and 34% for the aerobic, resistance, and impact-loading protocols, with 55%, 80%, and 37% of participants meeting a priori criteria (75% of protocol). Acceptability of the exercise program was high (mean, 82%; 95% confidence interval, 78%–87%) and highly supported by qualitative responses.

Conclusions
An individualized, high-intensity aerobic, resistance, and impact-loading exercise medicine program is safe and acceptable, and feasible by some measures for people with MM. Adherence to the prescribed exercise protocols was limited by comorbidities and disease symptoms. Strategies to improve unsupervised exercise completion are warranted in this population.
Queer identities in translation: a multilingual case study of Taktsis’ The third wedding wreath
Authors: Valkanou Theodora , Kourouni Kyriaki 
Published: August 2023

Κουίρ (queer) ταυτότητες σε μετάφραση: η περίπτωση του μυθιστορήματος Το Τρίτο Στεφάνι του Κώστα Ταχτσή σε διαφορετικές γλώσσεςΤο Τρίτο Στεφάνι του Κώστα Ταχτσή αποτελεί ένα εξαιρετικά δημοφιλές μυθιστό-ρημα της νεοελληνικής λογοτεχνίας, με υψηλές πωλήσεις επί σειρά ετών, παρά την αρχική του απόρριψη από πολλούς εκδότες, η οποία είχε ως αποτέλεσμα τη δημο-σίευσή του ιδίοις αναλώμασι το 1962. Το μυθιστόρημα έγινε διάσημο για την πρω-τοποριακή χρήση της γλώσσας, όπως αυτή αποτυπώνεται στις ζωντανές αφηγή-σεις ανάμεσα στις δύο πρωταγωνίστριες, και για την ανυπόκριτη αναπαράσταση της ελληνικής μικροαστικής τάξης της εποχής. Θεωρείται, επίσης, αξιόλογο έργο για την τολμηρή περιγραφή ρευστών σεξουαλικών ταυτοτήτων. Ο Ταχτσής απεικονίζει τις ομο- και αμφιφυλόφιλες αρσενικότητες σε συνδυασμό με το στοιχείο του κουίρ στη γλώσσα, προκειμένου να ανατρέψει τα ετεροκανονικά έμφυλα στερεότυπα που επικρατούσαν στην ελληνική κοινωνία της εποχής του. Η μελέτη, λαμβάνοντας υ-πόψη το πλούσιο υπο-κείμενο του μυθιστορήματος, εντοπίζει στοιχεία κουίρ στις περιγραφές των μη ετεροκανονικών χαρακτήρων και τις δραστηριότητές τους, κα-θώς και σημεία όπου αποτυπώνεται η διάσταση του κουίρ σε κειμενικό επίπεδο. Στη συνέχεια, εξετάζει συγκριτικά τη μεταφορά τους στις μεταφράσεις προς τα αγ-γλικά (Chioles, 1985), γαλλικά (Lacarrière, 1981), ιταλικά (Minucci, 1992) και γερ-μανικά (Josing-Gundert, 1984), με στόχο την εύρεση και ανάδειξη μοτίβων στην α-πόδοση του κουίρ στα συγκεκριμένα μεταφράσματα. Costas Taktsis’ The Third Wedding Wreath is an immensely popular long-selling Modern Greek novel, despite the fact that it was initially rejected by many publishers and eventually published at the author’s own expense in 1962. The novel has been acclaimed for its innovative use of language through the two female protagonists’ vivid narration and the unpretentious representation of the Greek petite-bourgeoisie of the time. Nonetheless, it is also considered a noteworthy novel for its bold portrayal of fluid sexual identities. Taktsis combines the depiction of homo- and bisexual masculinities with queerness in language to subvert the heteronormative gender stereotypes of the Greek society of his time. Taking into consideration the rich subtext of the novel, this paper locates features of queerness in descriptions of non-heteronormative characters and activities associated with them, as well as specific instances of queering on the textual level in the novel. It then contrastively examines their transfer in the translations into English (Chioles, 1985), French (Lacarrière, 1981), Italian (Minucci, 1992), and German (Josing-Gundert, 1984), seeking to identify emerging patterns with respect to the treatment of queerness in the specific translated texts.
Framework for virtual education of COVID-19 vaccines for Mandarin-speaking learners: an educational intervention module
Authors: Wang JiCi , Moy Benjamin M. , Kaufhold Ross T. , Muzaurieta Aurelio , Xia Yang , Jiang Shannon , Yim Angela , Chang Miller Jane , Zhou Shiwei , Lee Pearl , Hou Lisa , Lee Janilla , Heung Michael 
Published: August 2023

Background: In the United States, patients with limited English proficiency face significant barriers to comprehending and acting upon health-related information, particularly during the COVID-19 pandemic. The ability of health professionals to communicate COVID-19-related information to Mandarin-speaking patients has proved critical in discussions about vaccine efficacy, side effects, and post-vaccine protection. Methods: The authors created a one-hour educational module to help Mandarin-speaking medical students better convey COVID-19 vaccine information to Mandarin-only speakers. The module is composed of an educational guide, which introduced key terminology and addressed commonly asked questions, and pre- and post-surveys. The authors recruited 59 Mandarin-speaking medical students all of whom had previously completed a medical Mandarin elective. The module and surveys were distributed and completed in August 2021. Data analysis measured the change in aggregate mean for subjective five-point Likert-scale questions and change in percent accuracy for objective knowledge-based questions. Results: 86.4% of participants were primary English speakers with variable levels of Mandarin proficiency. The educational module significantly improved participants' subjective comfort level in discussing the COVID-19 vaccine in English and Mandarin. The largest improvement in both English and Mandarin was demonstrated in participants' ability to explain differences between the COVID-19 vaccines, with an aggregate mean improvement of 0.39 for English and 1.48 for Mandarin. Survey respondents also demonstrated increased percent accuracy in knowledge-based objective questions in Mandarin. Conclusions: This module provides Mandarin-learning medical students with skills to deliver reliable information to the general population and acts as a model for the continued development of educational modules for multilingual medical professionals.
High Discounts and Low Fundamental Surplus: An Equivalence Result for Unemployment Fluctuations
Authors: Mitra Indrajit , Seo Taeuk , Xu Yu 
Published: August 2023

We establish an observational equivalence between unemployment fluctuations of the Diamond-Mortensen-Pissarides search economy augmented with time varying risk premia and an otherwise identical economy without risk premia but with a time varying value of leisure. This equivalence holds for general risk premia processes and allows us to view the effects of different models of risk premia as operating through a single channel—one that alters the value of leisure. We derive simple expressions for semielasticities of labor market tightness with respect to productivity and risk premium shocks. We show wages can be used to detect misspecification in the discount rate process used in hiring decisions. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.03712 .
Binary Matrix Factorization and Completion via Integer Programming
Authors: Günlük Oktay , Hauser Raphael Andreas , Kovács Réka Ágnes 
Published: August 2023

Binary matrix factorization is an essential tool for identifying discrete patterns in binary data. In this paper, we consider the rank-k binary matrix factorization problem (k-BMF) under Boolean arithmetic: we are given an n × m binary matrix X with possibly missing entries and need to find two binary matrices A and B of dimension n × k and k × m, respectively, which minimize the distance between X and the Boolean product of A and B in the squared Frobenius distance. We present a compact and two exponential size integer programs (IPs) for k-BMF and show that the compact IP has a weak linear programming (LP) relaxation, whereas the exponential size IPs have a stronger equivalent LP relaxation. We introduce a new objective function, which differs from the traditional squared Frobenius objective in attributing a weight to zero entries of the input matrix that is proportional to the number of times the zero is erroneously covered in a rank-k factorization. For one of the exponential size Ips, we describe a computational approach based on column generation. Experimental results on synthetic and real-world data sets suggest that our integer programming approach is competitive against available methods for k-BMF and provides accurate low-error factorizations. Funding: O. Günlük was partially supported by the Office of Naval Research [Grant N00014-21-1-2575]. R. Á. Kovács was supported by a doctoral scholarship from The Alan Turing Institute under the EPSRC [Grant EP/N510129/1] and the Office for National Statistics. R. A. Hauser was supported by The Alan Turing Institute under the EPSRC [Grant EP/N510129/1].
Long-term rare giant sialolithiasis for 30 years: A case report and review of literature
Authors: Mao Jit-Swen , Lee Yu-Chien , Chi Jessie Chao-Yun , Yi Wan-Ling , Tsou Yung-An , Lin Chia-Der , Tai Chih-Jaan , Shih Liang-Chun 
Published: August 2023

BACKGROUND
Sialolithiasis is one of the most common salivary gland disorders, most commonly affecting the submandibular gland. Submandibular sialolithiasis can be treated using non-invasive conservative measures and invasive treatments. Treatment selection was based on the ductal system anatomy and the size and location of the stones. This study aimed to review the updates on sialolithiasis treatment and compare the different management strategies of the variables.
CASE SUMMARY
This report presents a case of a long-term, rare, and giant sialolithiasis within the submandibular gland parenchyma for 30 years in an older adult. Our patient presented with painless right submandibular swelling. Computed tomography revealed a calcified mass measuring 35 mm × 20 mm within the right submandibular gland. In this case, the infection and fibrosis of the affected gland and size of the stone did not provide us with other alternatives except for the excision of the involved gland. Thus, right submandibular sialoadenectomy was performed via the transcervical approach. After the surgery, the patient recovered without any complaints, side effects, or complications.
CONCLUSION
Tailored management is important for preserving gland function, maintaining low risk, and reducing patient discomfort.
Feasibility and Acceptability of Spanish-Language Parenting Interventions for Young Children With Developmental Delays
Authors: Safer-Lichtenstein Jonathan , McIntyre Laura Lee , Rodriguez Geovanna , Gomez Douglas , Puerta Stephanie , Neece Cameron L. 
Published: August 2023

AbstractHispanic/Latinx parents of children with developmental delays/disabilities (DD) face disparities in service access and research participation. In the present study, 60 Spanish-speaking caregivers of young children with DD participated in randomly assigned stress reduction interventions (psychoeducation/support groups or Mindfulness-Based Stress Reduction [MBSR]), followed by behavioral parent training (BPT). Caregiver attendance and satisfaction ratings were measured, and focus groups gathered additional information on caregivers' takeaways from the interventions. Caregivers demonstrated high satisfaction across interventions, with slightly greater preference for psychoeducation/support groups, and qualitative data indicated that the relevance of the information and style of delivery may be responsible. Researchers and clinicians may attain greater engagement with this population by focusing on intervention services that include psychoeducation and peer support elements.
Technical limits of sensitivity for EIT magnetometry
Authors: McKelvy J. A. , Maldonado M. A. , Novikova I. , Mikhailov E. E. , Matsko A. B. 
Published: August 2023

Optical magnetometers based on electromagnetically induced transparency
(EIT) in atomic vapor can in principle achieve outstanding sensitivity
and accuracy in a small volume. Up until now, however, the predicted
fundamental quantum-noise-limited sensitivity has not been achieved in
practice due to various technical limitations associated with the
measurement apparatus. Here we analyze these restrictions and propose
viable mitigation strategies for performance optimization. As an
example, we show that an EIT magnetometer can theoretically achieve
sensitivity better than 100 fT at 1 s measurement time
under realistic conditions.
Efficiency-boosted semiconductor optical amplifiers via mode-division multiplexing
Authors: Wang Yi , Wei Yihui , Dolores-Calzadilla Victor , Dai Daoxin , Williams Kevin , Smit Meint , Jiao Yuqing 
Published: August 2023

Semiconductor optical amplifiers (SOAs) are a fundamental building block for many photonic systems. However, their power inefficiency has been setting back operational cost reduction, circuit miniaturization, and the realization of more complex photonic functions such as large-scale switches and optical phased arrays. In this work, we demonstrate significant gain and efficiency enhancement using an extra degree of freedom of light—the mode space. This is done without changing the SOA’s material design, and therefore high versatility and compatibility can be obtained. Light is multiplexed in different guided modes and reinjected into the same gain section twice without introducing resonance, doubling the interaction length in a broadband manner. Up to 87% higher gain and 300% higher wall-plug efficiency are obtained in a double-pass SOA compared to a conventional single-pass SOA, at the same operating current, in the wavelength range of 1560–1580 nm.