bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Human Right to What Kind of Medicine?
Authors: Muyskens Kathryn 
Published: May 2023

AbstractThe human right to health, insofar as it is widely recognized, is typically thought to include the right to fair access to adequate healthcare, but the operating conception of healthcare in this context has been under-defined. This lack of conceptual clarity has often led in practice to largely Western cultural assumptions about what validly constitutes “healthcare” and “medicine.” Ethnocentric and parochial assumptions ought to be avoided, lest they give justification to the accusation that universal human rights are mere tools for Western imperial agendas. At the same time, a right to healthcare that is not also explicitly the right to effective healthcare rapidly loses meaning. This paper strives to provide an account of medicine with the flexibility to accommodate cultural difference in forms of practice, while also aiding in the articulation of a minimum for medical systems to meet the standards set out in a human right.
Impact, healthcare utilization and costs of travel-associated mosquito-borne diseases in international travellers: a prospective study
Authors: Tozan Yesim , Headley Tyler Y , Javelle Emilie , Gautret Philippe , Grobusch Martin , de Pijper Cornelis , Asgeirsson Hilmir , Chen Lin H , Bourque Daniel L , Menéndez Marta D , Moro Lucia , Gobbi Federico , Sánchez-Montalvá Adrián , Connor Bradley A , Matteelli Alberto , Crosato Verena , Huits Ralph , Libman Michael , Hamer Davidson H 
Published: May 2023

Abstract

Background
International travellers frequently acquire infectious diseases whilst travelling, yet relatively little is known about the impact and economic burden of these illnesses on travellers. We conducted a prospective exploratory costing study on adult returning travellers with falciparum malaria, dengue, chikungunya or Zika virus.

Methods
Patients were recruited in eight Travel and Tropical Medicine clinics between June 2016 and March 2020 upon travellers’ first contact with the health system in their country of residence. The patients were presented with a structured 52-question self-administered questionnaire after full recovery to collect information on patients’ healthcare utilization and out-of-pocket costs both in the destination and home country, and about income and other financial losses due to the illness.

Results
A total of 134 patients participated in the study (malaria, 66; dengue, 51; chikungunya, 8; Zika virus, 9; all fully recovered; median age 40; range 18–72 years). Prior to travelling, 42% of patients reported procuring medical evacuation insurance. Across the four illnesses, only 7% of patients were hospitalized abroad compared with 61% at home. Similarly, 15% sought ambulatory services whilst abroad compared with 61% at home. The average direct out-of-pocket hospitalization cost in the destination country (USD $2236; range: $108–$5160) was higher than the direct out-of-pocket ambulatory cost in the destination country (USD $327; range: $0–$1560), the direct out-of-pocket hospitalization cost at home (USD $35; range: $0–$120) and the direct out-of-pocket ambulatory costs at home (US$45; range: $0–$192). Respondents with dengue or malaria lost a median of USD $570 (Interquartile range [IQR] 240–1140) and USD $240 (IQR 0–600), respectively, due to their illness, whilst those with chikungunya and Zika virus lost a median of USD $2400 (IQR 1200–3600) and USD $1500 (IQR 510–2625), respectively.

Conclusion
Travellers often incur significant costs due to travel-acquired diseases. Further research into the economic impact of these diseases on travellers should be conducted.
MeerKAT view of the dancing ghosts – peculiar galaxy pair PKS 2130−538 in Abell 3785
Authors: Velović Velibor , Cotton William D , Filipović Miroslav D , Norris Ray P , Barnes Luke A , Condon James J 
Published: May 2023

ABSTRACT
We present MeerKAT L-band (886–1682 MHz) observations of the extended radio structure of the peculiar galaxy pair PKS 2130−538 known as the ‘Dancing Ghosts’. The complex of bending and possibly interacting jets and lobes originate from two active galactic nuclei hosts in the Abell 3785 galaxy cluster, one of which is the brightest cluster galaxy. The radio properties of the PKS 2130−538 – flux density, spectral index, and polarization – are typical for large, bent-tail galaxies. We also investigate a number of thin extended low surface brightness filaments originating from the lobes. South-east from the Dancing Ghosts, we detect a region of low surface brightness emission that has no clear origin. While it could originate from the Abell 3785 radio halo, we investigate the possibility that it is associated with the two PKS 2130−538 hosts. We find no evidence of interaction between the two PKS 2130−538 hosts.
Shift work characteristics and burnout among nurses: cross-sectional survey
Authors: Dall’Ora C , Ejebu O-Z , Ball J , Griffiths P 
Published: May 2023

Abstract

Background
Nurses working long shifts (≥12 h) experience higher levels of burnout. Yet other shift characteristics, including fixed versus rotating night work, weekly hours and breaks have not been considered. Choice over shift length may moderate the relationship; however, this has not been tested.

Aims
To examine the association between shift work characteristics and burnout and exhaustion, and whether choice over shift length influences burnout and exhaustion.

Methods
Cross-sectional online survey of nursing staff working in the UK and Ireland. We recruited two large National Health Service Trusts, through trade union membership, online/print nursing magazines and social media. We assessed associations using both univariable and multivariable generalized linear models.

Results
We had 873 valid responses. Reports of inadequate staffing levels (odds ratio [OR] = 2.84; 95% confidence interval [CI] 2.08–3.90) and less choice over shift length (OR = 0.20; 95% CI 0.06–0.54) were associated with higher burnout in multivariable models. Similar associations were found for exhaustion, where rarely or never taking breaks was also a predictor (OR = 1.61; 95% CI 1.05–2.52). Nurses who worked long shifts had less choice than those working shifts of 8 h or less (66% of 12-h shift nurses versus 44% 8-h shift nurses reporting having no choice), but choice did not moderate the relationship between shift length and burnout and exhaustion.

Conclusions
The relationship between long shifts and increased burnout reported previously might have arisen from a lack of choice for those staff working long shifts. Whether limited choice for staff is intrinsically linked to long shifts is unclear.
Safety and Effectiveness of Miltefosine in Post–Kala-Azar Dermal Leishmaniasis: An Observational Study
Authors: Sundar Shyam , Singh Jitendra , Dinkar Anju , Agrawal Neha 
Published: May 2023

Abstract

Background
Post–kala-azar dermal leishmaniasis (PKDL) is a dermal complication of visceral leishmaniasis. Oral miltefosine (MF) is the first-line treatment for PKDL patients in South Asia. This study assessed the safety and effectiveness of MF therapy after 12 months of follow-up to explore more precise data.

Methods
In this observational study, 300 confirmed PKDL patients were enrolled. MF with the usual dose was administered to all patients for 12 weeks and followed up for 1 year. Clinical evolution was recorded systematically by photographs at screening and at 12 weeks, 6 months, and 12 months after treatment onset. Definitive cure consisted of disappearance of skin lesions with a negative PCR at 12 weeks or with &gt;70% of lesions, disappearing or fading at 12-month follow-up. Patients with reappearing clinical features and any positive diagnostics of PKDL during the follow-up were considered as nonresponsive.

Results
Among 300 patients, 286 (95.3%) completed 12 weeks of treatment. The per-protocol cure rate at 12 months was 97%, but 7 patients relapsed and 51 (17%) were lost to 12-month follow-up, resulting in a final cure rate of only 76%. Eye-related adverse events were noted in 11 (3.7%) patients and resolved in most (72.7%) within 12 months. Unfortunately, 3 patients had persistent partial vision loss. Mild to moderate gastrointestinal side effects were seen in 28% patients.

Conclusions
Moderate effectiveness of MF was observed in the present study. A significant number of patients developed ocular complications, and thus MF for treatment for PKDL should be suspended and replaced with a safer alternative regimen.
Assembling India’s Constitution: Towards a New History
Authors: De Rohit , Shani Ornit 
Published: May 2023

Abstract
The framing of India’s constitution was a critical event in the global history of both constitution-making and democracy. Conventionally it has been analysed as a founding moment. Its success against multiple odds has been explained as resulting from a vision and consensus among the elite over what would become a pedagogical text for an ‘ignorant’ and undemocratic public. This focus among academics on political elites, and an underlying assumption that constitutional details were beyond the public’s imagination, limited the scope of investigations largely to the Constituent Assembly debates. By directing the inquiry away from these debates towards hitherto unstudied documents, this article offers a paradigm shift in the method of research and understanding of India’s constitution-making. It explores the constitution as it emerged from beyond the Constituent Assembly through engagement with its making among diverse publics. In doing so, it shows that the Indian constitution was not simply founded and granted from above, but came about through many smaller acts of assembly away from the Constitution Hall. It was the public who set normative expectations and tried to educate the members of the Constituent Assembly, and this was critical for the constitution’s future reception and endurance.
Sucrose Signaling Contributes to the Maintenance of Vascular Cambium by Inhibiting Cell Differentiation
Authors: Narutaki Aoi , Kahar Prihardi , Shimadzu Shunji , Maeda Shota , Furuya Tomoyuki , Ishizaki Kimitsune , Fukaki Hidehiro , Ogino Chiaki , Kondo Yuki 
Published: May 2023

Abstract
Plants produce sugars by photosynthesis and use them for growth and development. Sugars are transported from source-to-sink organs via the phloem in the vasculature. It is well known that vascular development is precisely controlled by plant hormones and peptide hormones. However, the role of sugars in the regulation of vascular development is poorly understood. In this study, we examined the effects of sugars on vascular cell differentiation using a vascular cell induction system named ‘Vascular Cell Induction Culture System Using Arabidopsis Leaves’ (VISUAL). We found that sucrose has the strongest inhibitory effect on xylem differentiation, among several types of sugars. Transcriptome analysis revealed that sucrose suppresses xylem and phloem differentiation in cambial cells. Physiological and genetic analyses suggested that sucrose might function through the BRI1-EMS-SUPPRESSOR1 transcription factor, which is the central regulator of vascular cell differentiation. Conditional overexpression of cytosolic invertase led to a decrease in the number of cambium layers due to an imbalance between cell division and differentiation. Taken together, our results suggest that sucrose potentially acts as a signal that integrates environmental conditions with the developmental program.
Vaccinium as a comparative system for understanding of complex flavonoid accumulation profiles and regulation in fruit
Authors: Albert Nick W , Iorizzo Massimo , Mengist Molla F , Montanari Sara , Zalapa Juan , Maule Andrew , Edger Patrick P , Yocca Alan E , Platts Adrian E , Pucker Boas , Espley Richard V 
Published: May 2023

Abstract
The genus Vaccinium L. (Ericaceae) contains premium berryfruit crops, including blueberry, cranberry, bilberry, and lingonberry. Consumption of Vaccinium berries is strongly associated with various potential health benefits, many of which are attributed to the relatively high concentrations of flavonoids, including the anthocyanins that provide the attractive red and blue berry colors. Because these phytochemicals are increasingly appealing to consumers, they have become a crop breeding target. There has been substantial recent progress in Vaccinium genomics and genetics together with new functional data on the transcriptional regulation of flavonoids. This is helping to unravel the developmental control of flavonoids and identify genetic regions and genes that can be selected for to further improve Vaccinium crops and advance our understanding of flavonoid regulation and biosynthesis across a broader range of fruit crops. In this update we consider the recent progress in understanding flavonoid regulation in fruit crops, using Vaccinium as an example and highlighting the significant gains in both genomic tools and functional analysis.
Dimension reduction of dynamics on modular and heterogeneous directed networks
Authors: Vegué Marina , Thibeault Vincent , Desrosiers Patrick , Allard Antoine 
Published: May 2023

AbstractDimension reduction is a common strategy to study nonlinear dynamical systems composed by a large number of variables. The goal is to find a smaller version of the system whose time evolution is easier to predict while preserving some of the key dynamical features of the original system. Finding such a reduced representation for complex systems is, however, a difficult task. We address this problem for dynamics on weighted directed networks, with special emphasis on modular and heterogeneous networks. We propose a two-step dimension-reduction method that takes into account the properties of the adjacency matrix. First, units are partitioned into groups of similar connectivity profiles. Each group is associated to an observable that is a weighted average of the nodes’ activities within the group. Second, we derive a set of equations that must be fulfilled for these observables to properly represent the original system’s behavior, together with a method for approximately solving them. The result is a reduced adjacency matrix and an approximate system of ODEs for the observables’ evolution. We show that the reduced system can be used to predict some characteristic features of the complete dynamics for different types of connectivity structures, both synthetic and derived from real data, including neuronal, ecological, and social networks. Our formalism opens a way to a systematic comparison of the effect of various structural properties on the overall network dynamics. It can thus help to identify the main structural driving forces guiding the evolution of dynamical processes on networks.
Gender Differences in Job Search and the Earnings Gap: Evidence from the Field and Lab
Authors: Cortés Patricia , Pan Jessica , Pilossoph Laura , Reuben Ernesto , Zafar Basit 
Published: May 2023

Abstract
This article investigates gender differences in the job search process in the field and lab. Our analysis is based on rich information on initial job offers and acceptances from undergraduates of Boston University’s Questrom School of Business. We find (i) a clear gender difference in the timing of job offer acceptance, with women accepting jobs substantially earlier than men, and (ii) a sizable gender earnings gap in accepted offers, which narrows in favor of women over the course of the job search period. To understand these patterns, we develop a job search model that incorporates gender differences in risk aversion and overoptimism about prospective offers. We validate the model’s assumptions and predictions using the survey data and present empirical evidence that the job search patterns in the field can be partly explained by the greater risk aversion displayed by women and the higher levels of overoptimism displayed by men. We replicate these findings in a laboratory experiment that features sequential job search and provide direct evidence on the purported mechanisms. Our findings highlight the importance of risk preferences and beliefs for gender differences in job-finding behavior and, consequently, early-career wage gaps among the highly educated.
Ultraprocessed food consumption, genetic predisposition, and the risk of gout: the UK Biobank study
Authors: Zhang Tingjing , Xu Xin , Chang Qing , Lv Yanling , Zhao Yuhong , Niu Kaijun , Chen Liangkai , Xia Yang 
Published: May 2023

Abstract

Objective
This study aimed to examine the interactions between ultraprocessed food (UPF) consumption and genetic predisposition with the risk of gout.

Methods
This prospective cohort study analysed 181 559 individuals from the UK Biobank study who were free of gout at baseline. UPF was defined according to the NOVA classification. Assessment of genetic predisposition for gout was developed from a genetic risk score of 33 single nucleotide polymorphisms. Cox proportional hazards were used to estimate the associations between UPF consumption, genetic predisposition and the risk of gout.

Results
Among the 181 559 individuals in the study, 1558 patients developed gout over 1 648 167 person-years of follow-up. In the multivariable adjustment model, compared with the lowest quartile of UPF consumption, the hazard ratio (HR) and 95% CI of the highest UPF consumption was 1.16 (1.01, 1.33) for gout risk, and there was a non-linear correlation between UPF consumption and the development of gout. In substitution analyses, replacing 20% of the weight of UPF in the daily intake with an equal amount of unprocessed or minimally processed food resulted in a 13% lower risk of gout (HR: 0.87; 95% CI: 0.79, 0.95). In the joint-effect analysis, the HR (95% CI) for gout was 1.90 (1.39, 2.60) in participants with high genetic predisposition and high UPF consumption, compared with those with low genetic predisposition and low UPF consumption.

Conclusion
In summary, UPF consumption was found to be associated with a higher risk of gout, particularly in those participants with genetic predisposition to gout. Our study indicated that reducing UPF consumption is crucial for gout prevention.
Mentalizing in an economic games context is associated with enhanced activation and connectivity in the left temporoparietal junction
Authors: Chang Li-Ang , Armaos Konstantinos , Warns Lotte , Ma de Sousa Ava Q , Paauwe Femke , Scholz Christin , Engelmann Jan B 
Published: May 2023

Abstract
Prior studies in Social Neuroeconomics have consistently reported activation in social cognition regions during interactive economic games, suggesting mentalizing during economic choice. Such mentalizing occurs during active participation in the game, as well as during passive observation of others’ interactions. We designed a novel version of the classic false-belief task (FBT) in which participants read vignettes about interactions between agents in the ultimatum and trust games and were subsequently asked to infer the agents’ beliefs. We compared activation patterns during the economic games FBT to those during the classic FBT using conjunction analyses. We find significant overlap in the left temporoparietal junction (TPJ) and dorsal medial prefrontal cortex, as well as the temporal pole (TP) during two task phases: belief formation and belief inference. Moreover, generalized Psychophysiological Interaction (gPPI) analyses show that during belief formation, the right TPJ is a target of both the left TPJ and the right TP seed regions, whereas during belief inferences all seed regions show interconnectivity with each other. These results indicate that across different task types and phases, mentalizing is associated with activation and connectivity across central nodes of the social cognition network. Importantly, this is the case for both the novel economic games and the classic FBTs.
Evaluation of Metabarcoding Methods for Plant Disease Surveillance
Authors: Newberry Eric A. , Srivastava Subodh , Nunziata Schyler O. , Mathew Reny , Mark Nakhla , Rívera Yazmín 
Published: May 2023

Metabarcoding holds great potential for general plant pathogen surveillance by providing an untargeted profile of the host microbiome. However, the standard marker utilized for microbiome analysis of prokaryotes, the 16 rRNA gene, offers limited diagnostic utility as it provides phylogenetic resolution primarily at the genus level, and universal primers often co-amplify plant DNA. Here, we evaluated two recently published universal primer sets targeting the DNA gyrase and RNA polymerase ß subunit genes ( gyrB and rpoB, respectively), relative to a plant discriminating 16S primer set (799F/1115R), as disease surveillance tools. Comparative analysis of a mock bacterial community, as well as naturally infected citrus variegated chlorosis samples, indicated that the gyrB method displayed optimal performance in the amplification of DNA across a broad taxonomic spectrum of plant-pathogenic bacteria, providing resolution at the species and, in some cases, subspecies levels. It also generated high-quality datasets with minimal to no co-amplification of plant DNA, outperforming the rpoB and 16S assays in these regards. Further evaluation revealed that the gyrB method displayed an overall linear trend in the detection of several diverse bacterial pathogens; however, it was at least an order of magnitude less sensitive than a standard real-time PCR assay. Finally, we demonstrate the potential of this method to disentangle a mixed population of Pantoea spp. associated with a rice-bacterial blight outbreak and identify putative novel pathogens that would otherwise be overlooked with conventional PCR-based tests. This work represents steps toward establishing a robust, untargeted metabarcoding method for general plant disease surveillance. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Bryostatin‐1 attenuates intestinal ischemia/reperfusion‐induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO‐1 signaling
Authors: Liu Mulin , Wen Hexin , Zuo Lugen , Song Xue , Geng Zhijun , Ge Sitang , Ge Yuanyuan , Wu Rong , Chen Shiyuan , Yu Chaowen , Gao Yong 
Published: May 2023

AbstractBryostatin‐1 (Bryo‐1) exerts antioxidative stress effects in multiple diseases, and we confirmed that it improves intestinal barrier dysfunction in experimental colitis. Nevertheless, there are few reports on its action on intestinal ischemia/reperfusion (I/R). In this study, we mainly explored the effect of Bryo‐1 on intestinal I/R injury and determined the mechanism. C57BL/6J mice underwent temporary superior mesenteric artery (SMA) obturation to induce I/R, on the contrary, Caco‐2 cells suffered to oxygen and glucose deprivation/reperfusion (OGD/R) to establish the in vitro model. RAW264.7 cells were stimulated with LPS to induce macrophage inflammation. The drug gradient experiment was used to demonstrate in vivo and in vitro models. Bryo‐1 ameliorated the intestinal I/R‐induced injury of multiple organs and epithelial cells. It also alleviated intestinal I/R‐induced barrier disruption of intestines according to the histology, intestinal permeability, intestinal bacterial translocation rates, and tight junction protein expression results. Bryo‐1 significantly inhibited oxidative stress damages and inflammation, which may contribute to the restoration of intestinal barrier function. Further, Bryo‐1 significantly activated Nrf2/HO‐1 signaling in vivo. However, the deletion of Nrf2 in Caco‐2 and RAW264.7 cells attenuated the protective functions of Bryo‐1 and significantly abolished the anti‐inflammatory effect of Bryo‐1 on LPS‐induced macrophage inflammation. Bryo‐1 protects intestines against I/R‐induced injury. It is associated with intestinal barrier protection, as well as inhibition of inflammation and oxidative stress partly through Nrf2/HO‐1 signaling.