bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of duration of adjuvant chemotherapy with S-1 (6 versus 12 months) for resected pancreatic cancer: the multicenter clinical randomized phase II postoperative adjuvant chemotherapy S-1 (PACS-1) trial
Authors: Kayashima Hiroto , Itoh Shinji , Shimokawa Mototsugu , Hayashi Hiromitsu , Takamori Hiroshi , Fukuzawa Kengo , Ninomiya Mizuki , Araki Kenichiro , Yamashita Yo-ichi , Sugimachi Keishi , Uchiyama Hideaki , Morine Yuji , Utsunomiya Tohru , Uwagawa Tadashi , Maeda Takashi , Baba Hideo , Yoshizumi Tomoharu 
Published: May 2023

Abstract
Background: Six months of adjuvant chemotherapy with S-1 is standard care for resected pancreatic cancer in Japan; however, the optimal duration has not been established. We aimed to evaluate the impact of duration of adjuvant chemotherapy with S-1.
Methods: We performed a multicenter, randomized, open-label, phase II study. Patients with histologically proven invasive pancreatic ductal carcinoma, pathological stage I–III, and no local residual or microscopic residual tumor were eligible. Patients were randomized 1:1 to receive 6 or 12 months of adjuvant chemotherapy with S-1. The primary endpoint was 2-year overall survival (OS). Secondary endpoints were disease-free survival (DFS) and feasibility.
Results: A total of 170 patients were randomized (85 per group); the full analysis set was 82 in both groups. Completion rates were 64.7% (6-month group) and 44.0% (12-month group). Two-year OS was 71.5% (6-month group) and 65.4% (12-month group) (hazard ratio (HR): 1.143; 80% confidence interval (CI): 0.841–1.553; P = 0.5758). Two-year DFS was 46.4% (6-month group) and 44.9% (12-month group) (HR: 1.069; 95% CI: 0.727–1.572; P = 0.6448). In patients who completed the regimen, 2-year DFS was 56.5% (6-month group) and 75.0% (12-month group) (HR: 0.586; 95% CI: 0.310–1.105; P = 0.0944). Frequent (≥ 5%) grade ≥ 3 adverse events comprised anorexia (10.5% in the 6-month group) and diarrhea (5.3% vs. 5.1%; 6- vs. 12-month group, respectively).
Conclusions: In patients with resected pancreatic cancer, 12 months of adjuvant chemotherapy with S-1 was not superior to 6 months regarding OS and DFS.
Geometrically Stable 3D-Point Cloud Encryption via Chaotic Permutations and Pointwise Rotations
Authors: Annaby M. H. , Mahmoud M. E. , Abdusalam H. A. , Ayad H. A. , Rushdi M. A. 
Published: May 2023

Abstract
Three-dimensional point-cloud data has been enormously abundant with the emergence of numerous technologies for 3D data acquisition, processing, and visualization. Encryption algorithms have been recently introduced to ensure secure storage and communication for this type of data. However, maintaining the correctness and the geometric stability of such algorithms are still key challenges towards the construction of reliable, trustful, and practical ciphers of 3D point clouds. Few attempts have been made to establish geometrically stable algorithms for 3D point cloud encryption, without compromising the cipher robustness. In particular, Jolfaei et al. [IEEE Transactions on Information Forensics and Security , vol. 10, no. 2, pp. 409-422, 2015] proposed a 3D object encryption algorithm along with geometric notions of dimensional and spatial stability. However, these notions are not consistent and the geometric stability and correctness of that cipher are not guaranteed as we show through counterexamples. In this paper, we introduce an enhanced cipher with correctness, reversibility, and geometric stability guarantees. The soundness and significance of the proposed scheme are demonstrated by rigorous mathematical proofs, extensive experimentation, and comparisons against state-of-the-art methods.
Effect of cold atmospheric surface micro-discharge plasma on the microbial safety and physicochemical property of Chinese yam flour
Authors: Yang Xudong , Ju Siyao , Liu Mengjie , Feng Junxia , Du Mengru , Zhuang Jie , Ma Ruonan , Jiao Zhen , Zhou Rusen , Cullen Patrick J. 
Published: May 2023

Abstract
Cold atmospheric plasma (CAP) as an emerging non-thermal technology holds great potential in food sterilization and biopolymer modification. This study investigated the antifungal effects of CAP against spoilage fungi in Chinese yam flour and its effects on the physicochemical and nutritional properties of Chinese yam flour. The results show that CAP treatment for 5–20 min achieved a microbial reduction of Fusarium moniliforme ranging from 0.56 to 2.40 log10 CFU/g at day 0 and 1.50 to 3.73 log10 CFU/g at day 9. The inactivation efficiency was increased with the CAP treatment time and storage time. For the physicochemical properties, CAP caused surface corrosion and formed aggregations on the surface of flour granules, as well as enhanced the absorption of carboxyl or carbonyl peak at 1730 cm− 1. The swelling power, starch solubility, and pasting viscosity of Chinese yam flour was increased after CAP treatment, while the endothermic enthalpy was decreased possibly due to the disruption of amorphous and crystalline structure of starch granules. A distinct color change was observed in CAP-treated Chinese yam flour, which became more bright and less yellow. The results of nutritional properties demonstrate that CAP caused a redistribution of dietary fiber components from insoluble to soluble fractions and changed the amino acids composition in Chinese yam flour. The SDS-PAGE analysis confirmed that CAP treatment could degrade or depolymerize the macromolecular proteins into small molecular subunits. Thus, CAP can be a promising technology to modify the physicochemical and nutritional properties of Chinese yam flour and ensure its microbial safety.
Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinoma
Authors: Shen Dongsheng , Wu Chenghao , Ding Zhongyue , Zhou Zixuan , Zhang Shasha , Li Huaifang , Tong Xiaowen , Zhu Xinxian , Guo Yi 
Published: May 2023

AbstractBackground Ovarian serous cystadenocarcinoma (OSC) is the most common pathological subtype of ovarian cancer (OC) associated with high mortality. Albeit dysregulated mitochondrial metabolism has been implicated with OC, the role of mitochondrial genes in OSC remains unclear. We sought to construct a model based on mitochondrial genes for prognosis prediction, drug guidance and immune feature analysis of OSC. Methods Differentially expressed genes (DEGs) and mitochondrial-related DEGs (MRGs) were identified through the Cancer Genome Atlas (TCGA)-OV dataset. Consensus clustering algorithm was applied to classify OSC patients into distinct MRGs subtypes. Prognosis-related MRGs were screened to construct the prognosis-related Risk score model, which was verified using GSE26193 dataset and immunohistochemistry (IHC) score model based on staining intensity and extent scores of MRGs. A visualized nomogram was developed to predict 1-, 3- and 5-year overall survival (OS) and drug response. The correlation of MRGs subtypes with risk subgroups and the association of Risk score model with immune response and infiltration were also investigated. Results 341 MRGs were identified from TCGA-OV, and OSC patients could be mainly divided into two MRGs subtypes. A novel prognostic Risk score model based on 7-MRGs, includingACOT13,ACSS3,COA6,HINT2,MRPL14,NDUFC2andNDUFV2, was developed and validated via GSE26193 dataset and IHC score model. Patients in the low-risk group had a significantly longer OS. The nomogram exhibited good prognostic assessment accuracy in both training and validation datasets. Drug sensitivity analysis indicated that cisplatin, paclitaxel and docetaxel were more sensitive in the low-risk group; VEGFR inhibitor Axitinib, and BRAF inhibitors Vemurafenib and SB590885 showed better sensitivity in the high-risk group; moreover, patients in the low-risk group could have better anti-PD-1 immunotherapy response. Patients in “cluster1” MRGs subtype had lower risk scores and better immunotherapy response scores than the “cluster2” subgroup. More significant infiltrated tumor killing cells (CD8+T cells) and higher M1 / M2 macrophage ratio were in “cluster1” patients. Conclusions Our novel 7 MRGs-based Risk score model has huge prospects to evaluate the prognosis and guide drug treatment. The favorable prognosis associated with the low-risk group is closely related to better immune response and more significant anti-tumor cellular infiltration.
Determinants of citations in tourism and hospitality studies
Authors: Correia Antonia , Rodrigues Paulo Manuel Marques , Kozak Metin , Raposo Pedro 
Published: May 2023

Abstract
Citation metrics are frequently used to assess research and rank journals and researchers. Nevertheless, this is still a process with asymmetric information. Tourism and hospitality research have matured within a small community and through a multidisciplinary scientific paradigm. This paper aims to understand the determinants of tourism and hospitality research citation patterns. To this end, a total of 101,968 papers within fifteen years (2004–2018) is analysed. Our empirical results suggest that authors’ prestige, the multidisciplinary nature of research, and the impact factor of journals and bibliometric articles are likely to increase an article’s citations. This paper represents a step forward in understanding the citation formation process in tourism and hospitality research.
Macro-micro elements distribution, nutritional value and age-based risk assessment of branded liquid and powder milks available in Dhaka, Bangladesh
Authors: Alam Md Nur E , Ullah A. K. M. Atique , Hosen M. Mozammal , Akon Shamima , Nahar Quamrun , Jolly Ferdousi , Quraishi Shamshad B. 
Published: May 2023

Abstract
This study aimed to assess the level of concentration, nutritional contribution, and possible health risk for various age groups owing to the consumption of branded liquid and powder milk. Using atomic absorption spectrometry, sixteen liquid and thirty powder milk samples were tested for 13 elements. The concentration of essential elements showed the trends of K>Ca>Na>Mg>Fe>Zn>Mn>Cu and K>Ca>Na>Mg>Fe>Cu>Mn>Zn for liquid and powder milk samples respectively but the potentially hazard metals/metalloids showed the same trends (Cr>Pb>Hg>As>Cd) for both items. Except for Cr, Hg, and Fe, the elemental compositions of both milk categories differed considerably (<0.05). When compared to the metals/metalloid’s threshold values for milk samples (liquid and powder): Fe (19% and 27%), Mn (100% and 63%), Cu (0% and 23%) Zn (94% and 0%), Pb (25% and 13%) and Cr (0% and 3%) were found to be above the permissible limits. The nutrient input from macro-minerals (Na, K, Ca, Mg) was highest for Ca (27.2% and 18.7%), followed by Mg, K, and Na. The estimated daily intake (EDI) of all trace metals/metalloids was within the daily permissible limit in both the milk category except age group (<3) and the female category. In terms of non-carcinogenic risk, the THQs and TTHQs levels compared to the threshold value (<1), the population of age groups ≤3 and 3<X≤14 especially female category will experience a more detrimental adverse effect. The probable carcinogenic risks indicated unacceptable risk level (<1.00E-04) for the ingestion of Cr through powder milk samples for child male and female categories.
Efficiency of New modified inverted Y Cleft lift advancement flap in primary and recurrent sacrococcygeal pilonidal sinus disease with low laying tracts near the anus
Authors: Elshazly Walid , Radwan Ahmed , abdelhalim Mohamed , MOAZ AHMED 
Published: May 2023

Abstract

Propose:
The aim of this study was to asses’ efficiency of the new modified inverted Y cleft lift procedure, utilizing an advancement flap technique with off-midline primary wound closure in-patient with lower pits of the sinus near to the anus.
Methods:
This clinical study conducted from September 2018 to september 2020. Forty patients with sacrococcygeal pilonidal sinus disease with lower pits near the anus new cases or recurrent. All patients offered the new modified inverted Y cleft lift advancement flap patients followed up for 48.5 (range, 21– 57) months Patients evaluated in terms of operation time, postoperative complications, recurrence rate, return-to-work time, and cosmetic satisfaction.
Results:
The average age was 27.4 (range, 16–52) years, 29 patient (72.5%) were male and 11 (27.5%) were female. The mean operating time was 25 (range, 22– 45) min. and the mean length of hospital stay was 0.8 (range, 0.4 − 2) days. Primary healing occurred in 35 (87.5%) patients. Complete healing for complicated wounds (5 patients) achieved in an average of 21 (14–60) days. Two (5%) patients developed a superficial wound infection, 4 (10%) a seroma and five (12.5%) a partial dehiscence (some complications observed in the same patient). There was no case of deep infection, haematoma formation or complete dehiscence.
Conclusion:
This series proved that the new modification inverted Y cleft lift flap reconstruction is an effective operative procedure for primary and recurrent pilonidal sinus with pits very near to the anus, associated with low complication and recurrence rates
An Inhomogeneous Model for Laser Welding of Industrial Interest
Authors: Munafó Carmelo Filippo , Palumbo Annunziata , Versaci Mario 
Published: May 2023

Abstract
An innovative non-homogeneous dynamic model for recovering the absolute temperature during the laser welding process of Al-Si 5% alloy plates, as per the industrial activity of an Italian company with proven experience operating in the laser welding area, is presented here. Firstly, the model considers that, metallurgically, during welding, the alloy melts with the presence of solid/liquid phases until total melting, and after-wards re-solidifies with the reverse process. Further, a particular polynomial substitute thermal capacity of the alloy has been chosen, according to experimental evidence, so that the volumetric solid state fraction is easily identifiable. Moreover, to the usual radiative/convective boundary conditions, to make the model more realistic, the contribution due to the positioning of the plates on the workbench is considered (endowing the model with Cauchy-Stefan-Boltzmann boundary conditions). Having verified the well-posedness of the problem, a Galerkin-FEM approach has been implemented on MatLab PDE ToolBox to numerically recover the absolute temperature maps, obtained by modeling the heat sources due to the laser with formulations depending on the laser sliding speed. The results achieved have shown good adherence to the experimental evidence, opening up interesting future scenarios for technology transfer.
Deferoxamine Reduces Endothelial Ferroptosis and Protects Cerebrovascular Function after Experimental Traumatic Brain Injury
Authors: Liang Yidan , Wang Yanglingxi , Sun Chao , Xiang Yi , Deng Yongbing 
Published: May 2023

Abstract
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly contributes to poor patient outcomes. Recent studies revealed the involvement of iron metabolism in neuronal survival, yet its effect on vasculature remains unclear. This study aims to explore the impact of endothelial ferroptosis on cerebrovascular function in TBI. A Controlled Cortical Impact (CCI) model was established in mice, resulting in a significant increase in iron-related proteins such as TfR1, FPN1, and FTH, as well as oxidative stress biomarker 4HNE. This was accompanied by a decline in expression of the ferroptosis inhibitor NCOA4. Moreover, Perls' staining and nonhemin iron content assay showed iron overload in brain microvascular endothelial cells (BMECs) and the ipsilateral cortex. Immunofluorescence staining revealed more FTH-positive cerebral endothelial cells, consistent with impaired perfused vessel density and cerebral blood flow. As a specific iron chelator, DFO treatment inhibited such ferroptotic proteins expression and the accumulation of lipid-reactive oxygen species following CCI, enhancing glutathione peroxidase(GPx) activity. DFO treatment significantly reduced iron deposition in endothelial cells and brain tissue, and increased density of the cerebral capillaries as well. Consequently, DFO treatment led to improvements in cerebral blood flow (as measured by laser speckle imaging) and behavioral performance (as measured by the NSS scoring, rotarod test, and Morris water maze test). Taken together, our results indicated that TBI induces remarkable iron disorder and endothelial ferroptosis, and DFO treatment may help maintain iron homeostasis and protect vascular function. This may provide a novel therapeutic strategy to prevent cerebrovascular dysfunction following TBI.
Neurobehavioral impairments predict specific cerebral damage in rat model of subarachnoid hemorrhage
Authors: Lynch Daniel G , Shah Kevin A , Powell Keren , Wadolowski Steven , Ayol Willians Tambo , Strohl Joshua J , Unadkat Prashin , Eidelberg David , Huerta Patricio T , Li Chunyan 
Published: May 2023

Abstract
Subarachnoid hemorrhage (SAH) is a severe form of stroke that can cause unpredictable and diffuse cerebral damage, which is difficult to detect until it becomes irreversible. Therefore, there is a need for a reliable method to identify dysfunctional regions and initiate treatment before permanent damage occurs. Neurobehavioral assessments have been suggested as a possible tool to detect and approximately localize dysfunctional cerebral regions. In this study, we hypothesized that a neurobehavioral assessment battery could be a sensitive and specific early warning for damage in discrete cerebral regions following SAH. To test this hypothesis, a behavioral battery was employed at multiple time points after SAH induced via an endovascular perforation, and brain damage was confirmed via postmortem histopathological analysis. Our results demonstrate that impairment of sensorimotor function accurately predict damage in the cerebral cortex (AUC: 0.905; sensitivity: 81.8%; specificity: 90.9%) and striatum (AUC: 0.913; sensitivity: 90.1%; specificity: 100%), while impaired novel object recognition is a more accurate indicator of damage to the hippocampus (AUC: 0.902; sensitivity: 74.1%; specificity: 83.3%) than impaired reference memory (AUC: 0.746; sensitivity: 72.2%; specificity: 58.0%). Tests for anxiety-like and depression-like behaviors predict damage to the amygdala (AUC: 0.900; sensitivity: 77.0%; specificity: 81.7%) and thalamus (AUC: 0.963; sensitivity: 86.3%; specificity: 87.8%), respectively. This study suggests that recurring behavioral testing can accurately predict damage in specific brain regions, which could be developed into a clinical battery for early detection of SAH damage in humans, potentially improving early treatment and outcomes.
Expression and localization of efflux drug transporters P-glycoprotein and breast cancer resistance protein (BCRP) in adult human pancreatic islet alpha and beta cells
Authors: Kwon Jihoon , Hwang Jaehyun , Kim Michelle S. , Tirona Rommel G. , Kim Richard B. , Wang Rennian , Schwarz Ute I. 
Published: May 2023

Abstract
P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are clinically important efflux transporters of the ATP-binding cassette (ABC) family of transporters, widely recognized for their broad substrate specificity associated with multidrug resistance in cancers and limiting substrate drug intracellular accumulation. While their expression and function in organs such as the intestine, liver and kidneys are well understood, there is little known concerning pancreatic islet cells. This study was aimed to characterize the expression and localization of P-gp and BCRP transporters in adult human pancreatic islets using quantitative reverse transcription PCR (qPCR) and dual immunofluorescent staining approaches. We showed that P-gp and BCRP were highly expressed in the islets compared to liver, and frequently colocalized with insulin or glucagon. These findings provide new insights regarding P-gp and BCRP abundance in beta and alpha cells suggesting a potential role for these efflux transporters in limiting islet cell injury to xenobiotics.
Nosemosis in Türkiye: Increasing prevalence and distribution on two decades, and phylogenetic network analysis based on SSU rRNA gene
Authors: AKPINAR Rahşan Koç , GÜRLER Ali Tümay , BÖLÜKBAŞI Cenk Soner , KAYA Selma , ARSLAN Serhat , AYDIN Coşkun , Türlek Şakir Önder , Çelik Sema Nur , Beyazıt Ayşen , Öncel Tareneh , Erol Ufuk , Çiftci Ayşe Türkan , Bastem Zekai , Şenel Mesut , Bozdeveci Arif , Karaoğlu Şengül Alpay , Yaldız Murat , Güven Gökhan , Küçükoğlu Bilal , Kurt Mitat 
Published: May 2023

Abstract
Nosemosis, one of the most important honeybee diseases, causes colony losses and low productivity worldwide. A national study were carried out to presence of nosemosis throughout Türkiye, determine the prevalence of Nosema cereane and Nosema apis, and perform the network analyses of the parasites. Specimens were collected from hives with no clinical signs. A total of 1194 European honey bee colonies in 400 apiaries from 40 provinces of Türkiye were examined by microscopic and molecular techniques. Nosemosis were found in all of 40 provinces. The prevalence ratio were 64.3 ± 3,0, 95%CI in apiaries and 40.5 ± 2,9, 95%CI in hives. N. ceranae DNA were detected all of positive hives, while N. ceranae and N. apis co-infection in only four colonies. In the last two decades, it has been observed that nozemosis has spread to all provinces and its prevalence has increased in all regions of Türkiye. All of the N. ceranae or N. apis samples examined were 100% identical within themselves. Network analysis showed that they were within largest haplotype reported worldwide.
Affine-Periodic Solutions for Newton systems
Authors: Guo Ruichao , Wang Hongren 
Published: May 2023

Abstract
This paper establishs existence theorem of affine-periodic solutions for second order Newton system via topological degree theory. The concept of affine-periodicity performs not only a kind of symmetry of space but also the periodic evolution of time, which is a general version of periodicity, anti-periodicity, harmonic-periodicity and quasi-periodicity.
AMS(MOS). Mathematics Subject Classification(2000): 34C25, 34B15, 47H11
Causal Relationship Between Gut Microbiome and Allergic Asthma: A Two-Sample Mendelian Randomization Study
Authors: Wan Wei , Qiu Yi , Ren Yingxiang , Huang Xinyi , Peng Andi , Yang Chunping 
Published: May 2023

Abstract
Background Growing evidence has well documented the close association between the gut microbiome and allergic respiratory disease, which has been notably represented by allergic asthma. However, it is unclear whether this association is a causal link. Therefore, we investigated the potential causal associations between the gut microbiome and allergic asthma or other allergic diseases.Methods In this study, we performed two-sample Mendelian randomization(MR) analyses by using the publicly available genome-wide association study (GWAS) summary data. Single-nucleotide polymorphisms (SNPs) that significantly correlated were selected as instrumental variables. The inverse variance weighted (IVW) method was used to examine the potential causal gut microbial genera for allergic asthma and other allergic diseases. The robustness of the primary findings of the MR analyses was ensured by using different sensitivity analyses.Results Combining the findings from multiple analyses, the host genetic-driven increases in Butyricimonas at the genus level were positively correlated with the risk of allergic asthma. In addition, phylum Bacteroidetes, class Bacteroidia, order Bacteroidales was also found to have negative associations with the risk of allergic asthma; genus Slackia was identified as having potential causal effects with allergic asthma. No clear evidence of pleiotropy and heterogeneity was observed in Butyricimonas. Butyricimonas was also found to have an association with allergic rhinitis, but not with other allergic diseases.Conclusion Our findings indicate that there are new gut microbial genera that were causally associated with the risk of allergic asthma and other allergic diseases, and offer novel insights into the pathogenesis of allergic respiratory diseases.