bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomaterials That Induce Immunogenic Cell Death
Authors: Li Di , Liu Siqi , Ma Yang , Liu Shixian , Liu Yahui , Ding Jianxun 
Published: April 2023

AbstractThe immune system takes part in most physiological and pathological processes of the body, including the occurrence and development of cancer. Immunotherapy provides a promising modality for inhibition and even the cure of cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells induced by chemotherapy, radiotherapy, phototherapy, bioactive materials, and so forth, triggers a series of cellular responses by causing the release of tumor‐associated antigens and damage‐associated molecular patterns, which ultimately activate innate and adaptive immune responses. Among them, the ICD‐induced biomaterials attract increasing conditions as a benefit of biosafety and multifunctional modifications. This Review summarizes the research progress in biomaterials for inducing ICD via triggering endoplasmic reticulum oxidative stress, mitochondrial dysfunction, and cell membrane rupture and discusses the application prospects of ICD‐inducing biomaterials in clinical practice for cancer immunotherapy.
Opioid‐free anaesthesia for surgical attenuation of a congenital extrahepatic portosystemic shunt in a dog
Authors: da Cunha Constança Ribeiro , dos‐Santos José Diogo Gonçalves 
Published: April 2023

AbstractAnimals with impaired hepatic metabolism may experience reduced effect from some anaesthetic drugs and are more prone to developing unwanted side effects. Due to reduced blood flow to the liver, it is important to carefully select anaesthetic drugs in patients with extrahepatic shunt. We present the case in which a dog was submitted for surgical attenuation of congenital extrahepatic portosystemic shunt through placement of an ameroid constrictor. A multimodal regimen was designed in order to provide an opioid‐free anaesthesia, relying on analgesia through a locoregional quadratus lumborum block with bupivacaine. Dexmedetomidine was administered intramuscularly as pre‐anaesthetic medication, propofol was used for the induction and anaesthesia was maintained with isoflurane. The present case describes the first case in which an extrahepatic portosystemic shunt was surgically treated using an opioid‐free anaesthesia in a dog.
The interdisciplinary science of autobiographical memory
Authors: El Haj Mohamad 
Published: April 2023

AbstractTo provide a comprehensive understanding of the characteristics of autobiographical memory, WIREs Cognitive Science is launching a special issue gathering contributions from various perspectives in the field of autobiographical memory. To introduce this special issue, I outline the philosophy of this collaborative project and summarize the knowledge gained from each of the 12 articles included. Insights into the next important steps in studying autobiographical memory are also provided. As shown in this article, research on autobiographical memory covers a wide range of disciplines (e.g., neuropsychology, cognitive psychology, social psychology, developmental psychology, neurology, psychiatry). However, there has been little interdisciplinary dialogue between autobiographical memory scholars until recently. For the first time, this special issue brings together theoretical contributions that offer different yet complementary approaches to the study of autobiographical memory.This article is categorized under:
Psychology > Memory
On the Symmetries of a Kaehler Manifold
Authors: Albujer Alma L. , Alcázar Jorge , Caballero Magdalena 
Published: April 2023

AbstractThe natural symmetries of Riemannian manifolds are described by the symmetries of its Riemann curvature tensor. In that sense, the most symmetric manifolds are the constant sectional curvature ones. Its natural generalizations are locally symmetric manifolds, semisymmetric manifolds, and pseudosymmetric manifolds. The analogous generalizations of constant holomorphic sectional curvature Kaehler manifolds are locally symmetric Kaehler manifolds, semisymmetric Kaehler manifolds, and holomorphically pseudosymmetric Kaehler manifolds. Do they differ in some way from their Riemannian analogues? Yes, we prove they can all be characterized only in terms of holomorphic planes. Furthermore, the concept of holomorphically pseudosymmetric Kaehler manifold is different from the classical notion of pseudosymmetric Riemannian manifold proposed by Deszcz. We study some relations between both definitions of pseudosymmetry and the so called double sectional curvatures in the sense of Deszcz. We also present a geometric interpretation of the complex Tachibana tensor and a new characterization of constant holomorphic sectional curvature Kaehler manifolds.
Analysis of self-tapping screw joints in fibre glass reinforced PEI polymer used in the automotive industry
Authors: Cumbicus Wilmer E. , Estrems Manuel , Arizmendi Miguel , Jiménez Amaya 
Published: April 2023

AbstractThis article presents a study of the joining of polyetherimide (PEI) polymer parts reinforced with fibre glass which has great application in the automotive sector. A simulation model based on the finite element method is proposed. For the modelling of the polymeric material, the three-network viscoplastic (TNV) rheological model was used, with very adequate results and producing a good fit with the experimental data. In addition, a methodology is proposed that allows simplifying a three-dimensional to an axisymmetric model, which implies a notable reduction in computational cost. In addition, the work includes an experimental analysis that evaluates the tightening torque under conditions of assembly repetitiveness, relaxation over time and influence of thermal cycles. These scenarios have a different influence depending on the geometry of the self-tapping screw used. Regarding repetitiveness, it has been verified that PF-30 (CELOspArk®) loses 17.16% while in Δ-PT (DELTA PT®) it loses up to 41.93% in the tenth repetition. In contrast, in the relaxation over time scenario, the PF-30 loses 13.38% and the Δ-PT loses 17.82%. Finally, regarding the thermal cycles, cooling allows to slightly delay the loss of tightening torque in both screws in a similar way; however, in the heating stage, 36.89% is lost with PF-30 and only 14.66% with Δ-PT. This study represents an improvement in the knowledge of the joining processes of self-tapping screws with polymeric materials of an engineering nature. The simulation model can be easily adapted to other materials and other geometries, and the experimental study offers a vision of the evolution of tightening conditions in realistic operating scenarios.
A study on the EDM drilling of reaction-bonded silicon carbide using different electrode materials
Authors: Torres-Salcedo Alexia , Luis-Pérez Carmelo Javier , Puertas-Arbizu Ignacio , Corres-Sanz Jesús María 
Published: April 2023

AbstractToday, there is a growing demand for efficient hole manufacturing technology in many industries such as aeronautics, automotive and nuclear, among others. Thus, the present study deals with the machining of through holes on SiSiC advanced ceramic by using Electrical Discharge Machining (EDM) drilling technology. Since recommendations related to the electrode characteristics and settings parameters are found to be scant for the industrial use of EDM drilling of SiSiC ceramics, this research work comes to cover this gap as it presents a complete study focused on the influence on different electrodes under rough and finish machining conditions. In particular, the influence of four electrodes materials (copper, copper-tungsten, graphite and copper infiltrated graphite) and three different electrode diameters ranging from 2 to 4 mm are investigated. In addition, the rotational speed of the electrode is also analysed. From the experimental results, both electrode material and machining regime, seem to be the most relevant factors of all. In the case of 2 mm diameter electrode, material removal rate (MRR) with Cu electrode was, approximately, 4.5 times higher than that obtained with a C electrode. In fact, it was found that copper electrode rotating at 20 rpm combined with high values of discharge energy (I = 2 A; ti = 70 µs) is the most economical option in terms of production cost and production time, as it gives a high MRR of 0.4754 mm3/min and a minimum electrode wear (EW) value of 7.52%. Moreover, slightly higher values of MRR were achieved for CuC electrode compared to those obtained with C electrode, indicating that the addition of Cu in the electrode contributes to a greater removal of material. However, a value of Ra of 0.37 µm could be obtained by setting low current intensity values (I = 0.5 A; ti = 45 µs) combined with C electrodes and with no rotation.
Nedosiran in primary hyperoxaluria subtype 3: results from a phase I, single-dose study (PHYOX4)
Authors: Goldfarb David S. , Lieske John C. , Groothoff Jaap , Schalk Gesa , Russell Kerry , Yu Shuli , Vrhnjak Blaz 
Published: April 2023

Abstract
Nedosiran is an N-acetyl-D-galactosamine (GalNAc)–conjugated RNA interference agent targeting hepatic lactate dehydrogenase (encoded by the LDHA gene), the putative enzyme mediating the final step of oxalate production in all three genetic subtypes of primary hyperoxaluria (PH). This phase I study assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of subcutaneous nedosiran in patients with PH subtype 3 (PH3) and an estimated glomerular filtration rate  ≥ 30 mL/min/1.73 m2. Single-dose nedosiran 3 mg/kg or placebo was administered in a randomized (2:1), double-blinded manner. Safety/tolerability, 24-h urinary oxalate (Uox) concentrations, and plasma nedosiran concentrations were assessed. The main PD endpoint was the proportion of participants achieving a > 30% decrease from baseline in 24-h Uox at two consecutive visits. Six participants enrolled in and completed the study (nedosiran, n = 4; placebo, n = 2). Nedosiran was well-tolerated and lacked safety concerns. Although the PD response was not met, 24-h Uox excretion declined 24.5% in the nedosiran group and increased 10.5% in the placebo group at Day 85. Three of four nedosiran recipients had a > 30% reduction in 24-h Uox excretion during at least one visit, and one attained near‐normal (i.e., ≥ 0.46 to < 0.60 mmol/24 h; ≥ 1.0 to < 1.3 × upper limit of the normal reference range) 24-h Uox excretion from Day 29 to Day 85. Nedosiran displayed predictable plasma PK. The acceptable safety and trend toward Uox-lowering after single-dose nedosiran treatment enables further clinical development of nedosiran in patients with PH3 who currently have no viable therapeutic options. A plain language summary is available in the supplementary information.
Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major
Authors: Meloni Antonella , Nobile Mario , Keilberg Petra , Positano Vincenzo , Santarelli Maria Filomena , Pistoia Laura , Spasiano Anna , Casini Tommaso , Putti Maria Caterina , Cuccia Liana , Bitti Pier Paolo , Messina Giuseppe , Peritore Giuseppe , Renne Stefania , Grassedonio Emanuele , Quaia Emilio , Cademartiri Filippo , Pepe Alessia 
Published: April 2023

Abstract
Objectives
This multicenter study assessed the extent of pancreatic fatty replacement and its correlation with demographics, iron overload, glucose metabolism, and cardiac complications in a cohort of well-treated patients with thalassemia major (TM).

Methods
We considered 308 TM patients (median age: 39.79 years; 182 females) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network. Magnetic resonance imaging was used to quantify iron overload (IO) and pancreatic fat fraction (FF) by T2* technique, cardiac function by cine images, and to detect replacement myocardial fibrosis by late gadolinium enhancement technique. The glucose metabolism was assessed by the oral glucose tolerance test.

Results
Pancreatic FF was associated with age, body mass index, and history of hepatitis C virus infection. Patients with normal glucose metabolism showed a significantly lower pancreatic FF than patients with impaired fasting glucose (p = 0.030), impaired glucose tolerance (p < 0.0001), and diabetes (p < 0.0001). A normal pancreatic FF (< 6.6%) showed a negative predictive value of 100% for abnormal glucose metabolism. A pancreatic FF > 15.33% predicted the presence of abnormal glucose metabolism. Pancreas FF was inversely correlated with global pancreas and heart T2* values. A normal pancreatic FF showed a negative predictive value of 100% for cardiac iron. Pancreatic FF was significantly higher in patients with myocardial fibrosis (p = 0.002). All patients with cardiac complications had fatty replacement, and they showed a significantly higher pancreatic FF than complications-free patients (p = 0.002).

Conclusion
Pancreatic FF is a risk marker not only for alterations of glucose metabolism, but also for cardiac iron and complications, further supporting the close link between pancreatic and cardiac disease.

Key Points
• In thalassemia major, pancreatic fatty replacement by MRI is a frequent clinical entity, predicted by a pancreas T2* < 20.81 ms and associated with a higher risk of alterations in glucose metabolism.
• In thalassemia major, pancreatic fatty replacement is a strong risk marker for cardiac iron, replacement fibrosis, and complications, highlighting a deep connection between pancreatic and cardiac impairment.
Multicenter comparison of transcatheter aortic valve implantation with the self-expanding ACURATE neo2 versus Evolut PRO transcatheter heart valves
Authors: Rheude Tobias , Pellegrini Costanza , Landt Martin , Bleiziffer Sabine , Wolf Alexander , Renker Matthias , Neuser Jonas , Dörr Oliver , Allali Abdelhakim , Rudolph Tanja K. , Wambach Jan Martin , Widder Julian D. , Singh Parminder , Berliner Dominik , Alvarez-Covarrubias Hector A. , Richardt Gert , Xhepa Erion , Kim Won-Keun , Joner Michael 
Published: April 2023

Abstract
Background
New-generation self-expanding transcatheter aortic heart valves (THV) were designed to overcome technical constraints of their preceding generations. We sought to compare the efficacy and safety of the self-expanding ACURATE neo2 (Neo2) versus Evolut PRO (PRO) devices.

Methods
Seven hundred nine patients undergoing transfemoral transcatheter aortic valve implantation (TAVI) with either Neo2 (n = 496) or PRO (n = 213) were included. Propensity score matching (PSM) was performed to account for differences in baseline characteristics. In-hospital and 30-day clinical outcomes were evaluated according to Valve Academic Research Consortium-3 criteria.

Results
Baseline characteristics were comparable between both groups after PSM (Neo2: n = 155, Evolut Pro: n = 155). Technical success rates were high in both groups (Neo2: 94.8% vs PRO: 97.4%; p = 0.239). Need for permanent pacemaker implantation was less frequent with Neo2 compared with PRO (7.5% vs 20.6%; p = 0.002), whereas major vascular complications were more frequent with Neo2 (Neo2: 11.6% vs PRO: 4.5%; p = 0.022). Intended valve performance at discharge was high in both groups without relevant differences among groups (Neo2: 97.4% vs. 95.3%; p = 0.328).

Conclusions
Short-term outcomes after TAVI using latest-generation self-expanding THV were excellent, with overall low rates of adverse events. However, Neo2 was associated with lower pacemaker rates and reduced the prevalence of moderate–severe paravalvular leakage. Transprosthetic gradients after TAVI were higher with Neo2 compared with PRO.

Graphical abstract
Relationship between the main components of the crystalline lens and the anterior chamber depth after cataract formation
Authors: Díez-Montero Cecilia , López-de la Rosa Alberto , López-Miguel Alberto , Maldonado Miguel J. 
Published: April 2023

Abstract

Purpose
To assess the relationship between anterior chamber depth (ACD) and lens thickness (LT), as well as its three main components (anterior and posterior cortex and nucleus thickness), in cataractous and non-cataractous eyes, depending on the axial length (AxL).

Methods
Anterior and posterior cortex and nucleus thickness of the crystalline lens, ACD, and AxL were measured using optical low-coherence reflectometry in cataractous and non-cataractous eyes. They were also classified into hyperopia, emmetropia, myopia, and high myopia, depending on AxL; thus, eight subgroups were created. A minimum sample size of 44 eyes (of 44 patients) for each group was recruited. Linear models were fitted for the whole sample and each AxL subgroup to assess if there were differences in the relationships between the crystalline lens variables and ACD, including age as a covariate.

Results
Three hundred seventy cataract patients (237 females, 133 males) and 250 non-cataract controls (180 females, 70 males), aged 70.5 ± 9.4 and 41.9 ± 15.5 years, respectively, were recruited. The mean AxL, ACD, and LT for the cataractous and non-cataractous eyes were 23.90 ± 2.05, 24.11 ± 2.11, 2.64 ± 0.45, and 2.91 ± 0.49, 4.51 ± 0.38, 3.93 ± 0.44 mm, respectively. The inverse relationship of LT, anterior and posterior cortex, and nucleus thickness with ACD was not significantly (p ≥ 0.26) different between cataractous and non-cataractous eyes. Further subclassification of the sample depending on AxL showed that the inverse relationship between the posterior cortex and ACD was no longer significant (p > 0.05) for any non-cataractous AxL group. LT, anterior and posterior cortex, and nucleus thickness was not significantly (p ≥ 0.43) different between cataractous and non-cataractous eyes for the whole sample, and all AxL groups after adjusting for age.

Conclusions
The presence of cataracts does not modify the inverse relationship of the LT, anterior and posterior cortex, and nucleus with ACD. And this relationship does not seem to depend importantly on AxL. Besides, the possible differences in LT, anterior and posterior cortex, and nucleus between cataractous and non-cataractous eyes may not be caused by lens opacification, but possibly by the progressive lens growth due to aging.
Deutschrap als innovatives Instrument des Regionalmarketings? Die Vermarktung geographischer Imaginationen Ostdeutschlands in Rapmusik
Authors: Auge Yelva , Ringel Florian , Fleischmann Larissa 
Published: April 2023

ZusammenfassungIn diesem Beitrag arbeiten wir heraus, inwiefern Deutschrap ein innovatives Instrument des Regionalmarketings darstellt, das zur gezielten Vermarktung bestimmter geographischer Imaginationen über Orte und Regionen eingesetzt werden könnte. Hintergrund ist die im August 2022 gestartete und mit 260.000 € bezifferte Werbekampagne des Landesmarketings Brandenburg „jwd – jeder will dahin“, die das Ziel verfolgte, einen weitreichenderen Imagewandel zu bewirken, indem das Flächenland als attraktiver Wohn- und Gewerbestandort vermarktet werden sollte. In diesem Zusammenhang wurde der Rapper Finch engagiert, einen Raptrack zu veröffentlichen, welcher schon nach kurzer Zeit als neue „Brandenburg-Hymne“ in den Medien diskutiert wurde. Ziel dieses Beitrags ist es, am Beispiel des Rappers Finch zu analysieren, welches Image von Ostdeutschland im Deutschrap gezeichnet und zu kommerziellen Zwecken vermarktet wird. Wir werden dabei aufzeigen, dass Deutschrap zwar in kurzer Zeit eine hohe Reichweite bei speziell jüngeren Zielgruppen generieren kann, die Werbekampagne des Landes Brandenburgs durch die Auswahl des Rappers Finch jedoch schlussendlich Gefahr läuft, stereotypische und klischeehafte geographische Imaginationen über Ostdeutschland zu reproduzieren und damit zu einer Stigmatisierung dieser Region beizutragen.
Kommunikativer Umgang mit Angst und Depressivität bei Krebspatienten im Arzt-Patienten-Gespräch
Authors: Weißflog Gregor , Götze Heide 
Published: April 2023

Zusammenfassung
Hintergrund
Viele Krebspatienten leiden im Verlauf ihrer Erkrankung und -behandlung, aber zum Teil auch Jahre nach Abschluss der Behandlung unter psychischen Belastungen wie Angst und Depressivität.

Ziel der Arbeit
Diese Übersichtsarbeit informiert auf der Basis des aktuellen Forschungsstands darüber, wie im Arzt-Patienten-Kontakt Symptome von Angst und Depression erkannt, schweregradmäßig eingeordnet und mithilfe adäquater Kommunikation gelindert werden können und bei Bedarf weitere Experten mit einbezogen werden („stepped care“).

Ergebnisse
Für eine erste valide Einschätzung von Angst und Depressivität liegen Screeninginstrumente vor, die leicht im persönlichen Arzt-Patienten-Gespräch einsetzbar sind. Eine patientenzentrierte Kommunikation hilft in Gesprächen der regulären onkologischen Versorgung, Angst und Depressivität der Patienten zu lindern. Diese Patientenzentrierung kann dabei u. a. durch adäquate Informationsbereitstellung, die Unterstützung der Patientenautonomie und auch durch die Förderung einer Toleranz für Ungewissheit kommunikativ mit Leben gefüllt werden. Konkret kann dies durch anxiolytisch und antidepressiv wirkende Kommunikationsstrategien und -techniken wie z. B. „pacing and leading“, Reorientierungsübungen und den Rückgriff auf „mastery“ erreicht werden. Des Weiteren wird im Beitrag ein Fokus auf das COMSKIL-Modell gerichtet, das einen theoretischen Rahmen für die konkreten Kommunikationstechniken bereitstellt. Es liegt ebenso als Kommunikationstrainingsprogramm für onkologisch Tätige vor. Vor dem Hintergrund des Stepped-care-Ansatzes ist es hilfreich, Patienten bei Bedarf über psychoonkologische Versorgungsangebote vor Ort informieren zu können.
Delivering transgender-specific knowledge and skills into health and allied health studies and training: a systematic review
Authors: Jecke L. , Zepf F. D. 
Published: April 2023

AbstractMany transgender individuals face inequities, discrimination, and sometimes even a lack of transgender-specific knowledge in health care settings. Educational curricula can address such disparities and help future health professionals to become more knowledgeable, confident, and well-prepared for addressing the needs of transgender individuals. This systematic review aims to summarize current training interventions about care of transgender individuals for health and allied health students, and to analyse the effects of the respective intervention. A total of six databases (Pubmed, MEDLINE, Scopus, Web of Science, Embase and SciSearch) were screened for original articles published between 2017 and June 2021. Search terms and eligibility criteria were pre-specified, and after a structured selection process 21 studies were included into further analysis. Extracted data contained information on general study properties, population, design, program format and outcomes of interest. A narrative synthesis was used to summarize detected results. Study quality was assessed for each individual study. A self-developed 18-item checklist combining criteria of two prior published tools was used to assess overall quality of quantitative studies. For qualitative studies a 10-item checklist by Kmet et al. [HTA Initiat, 2004] was applied. Eligible studies were designed for multiple health or allied health profession students, and varied widely regarding program format, duration, content, and assessed outcomes. Almost all (N = 19) interventions indicated improvements in knowledge, attitude, confidence and comfort levels or practical skills concerning care for transgender clients. Major limitations included the lack of long-term data, validated assessment tools, control groups and comparative studies. Training interventions contribute to prepare future health professionals to deliver competent and sensitive care and which may improve the prospective experienced health care reality of transgender individuals. However, currently there is no common consensus about best practice of education. Additionally, little is known about whether detected effects of training interventions translate into noticeable improvements for transgender clients. Further studies are warranted to assess the direct impact of specific interventions in the light of the respective target populations.