bluuebunny/crossref_metadata_2025_split huggingface dataset:
How media content influences economic expectations: Evidence from a global expert survey
Authors: Boumans Dorine , Müller Henrik , Sauer Stefan 
Published: February 2023

AbstractThis article sheds light on the impact of the media on economists' expectations for future economic developments. We conducted a worldwide economic expert survey and find that the media provides most economists with valuable information that influences their expectations. This applies significantly more for economists in countries with long standing democratic systems and developing countries with somewhat flawed democratic institutions than for economists in newer democracies and countries with authoritarian regimes. Moreover, the experts estimate the influence of the media remarkably higher on others than on themselves. This is consistent with the theory of the third‐person effect that says that an individual's behavior is influenced due to the belief that other people find certain issues important and act accordingly.
Convergent dysbiosis of upper aerodigestive microbiota between patients with esophageal and oral cavity squamous cell carcinoma
Authors: Zhu Hengyan , Yip Hon Chi , Cheung Man Kit , Chan Hiu Ching , Ng Cherrie , Lau Eric H. L. , Yeung Zenon W. C. , Wong Eddy W. Y. , Leung Leanne , Qu Xinyu , Wang Daijuanru , Cai Liuyang , Chan Paul K. S. , Chan Jason Y. K. , Chen Zigui 
Published: February 2023

AbstractThe bidirectional association between primary esophageal squamous cell carcinoma (ESCC) and oral cavity squamous cell carcinoma (OSCC) suggests common risk factors and oncogenic molecular processes but it is unclear whether these two cancers display similar patterns of dysbiosis in their upper aerodigestive microbiota (UADM). We conducted a case‐control study to characterize the microbial communities in esophageal lavage samples from 49 ESCC patients and oral rinse samples from 91 OSCC patients using 16S rRNA V3‐V4 amplicon sequencing. Compared with their respective non‐SCC controls from the same anatomical sites, 32 and 45 discriminative bacterial genera were detected in ESCC and OSCC patients, respectively. Interestingly, 20 of them were commonly enriched or depleted in both types of cancer, suggesting a convergent niche adaptation of upper aerodigestive SCC‐associated bacteria that may play important roles in the pathogenesis of malignancies. Notably, Fusobacterium, Selenomonas, Peptoanaerobacter and Peptostreptococcus were enriched in both ESCC and OSCC, whereas Streptococcus and Granulicatelia were commonly depleted. We further identified Fusobacterium nucleatum as the most abundant species enriched in the upper aerodigestive SCC microenvironment, and the higher relative abundances of Selenomonas danae and Treponema maroon were positively correlated with smoking. In addition, predicted functional analysis revealed several depleted (eg, lipoic acid and pyruvate metabolism) and enriched (eg, RNA polymerase and nucleotide excision repair) pathways common to both cancers. Our findings reveal a convergent dysbiosis in the UADM between patients with ESCC and OSCC, suggesting a shared niche adaptation of host‐microbiota interactions in the pathogenesis of upper aerodigestive tract malignancies.
Childhood trauma and internalizing and externalizing behavior problems among adolescents: Role of executive function and life events stress
Authors: Wei Xiaomin , Lü Wei 
Published: February 2023

AbstractIntroductionExposure to childhood trauma is found to increase internalizing and externalizing behavior problems in adolescents, however, the potential mechanism of this link remains underexplored. This study investigated the associations between childhood trauma and internalizing and externalizing behavior problems among adolescents, and tested the mediating role of executive function and the moderating role of life events stress in this relationship.MethodsQuestionnaire data were collected from 952 junior students in Northwest China. Participants ranged in age from 11 to 15 years old (M = 12.88 years, SD = 0.72; 53% females). SPSS 26.0 was used to analyze the relationship between variables and examine the mediation model and the moderated mediation model.ResultsChildhood trauma was positively associated with internalizing and externalizing behavior problems among adolescents. In addition, executive function partially mediated the relations between childhood trauma and internalizing and externalizing behavior problems. Life events stress was observed to moderate the relations between childhood trauma and executive function, as well as executive function and internalizing and externalizing behavior problems, but the effect sizes were relatively small.ConclusionsThese findings underscore the role of executive function and life events stress in the association between childhood trauma and behavioral problems among adolescents.
Role of the heat shock protein family in chlorpromazine‐induced cardiotoxicity
Authors: Qishuo Tian , Youyou Zhang , Jie Zhang , Yalei Yu , Wei Zhang , Quan Liu , Liang Liu , Liang Ren 
Published: February 2023

AbstractChlorpromazine (CPZ), a first‐generation antipsychotic, is widely used in treating schizophrenia and other psychiatric disorders. However, CPZ is also associated with an increased likelihood of sudden cardiac death, and the underlying mechanisms remain unclear. In our study, we aimed to determine the CPZ‐induced changes in some members of the heat shock protein family in rat hearts and further explore the possible mechanisms of CPZ‐induced cardiotoxicity. Twenty‐four Sprague Dawley rats were randomly divided into three groups (n = 8 per group): control, low dose (33.216 mg/kg) and high dose (94.211 mg/kg). CPZ administration induced hypothermia in rats. Pathological changes, including ischaemia and hypoxia, were observed in rat hearts. Furthermore, the serum levels of cardiac Troponin T (c‐TN‐T) and brain natriuretic peptide (BNP) were elevated in the CPZ‐exposed groups. Meanwhile, the protein and gene expression of HSP70, HSP60, HSP27 and HSP10 significantly differed between the CPZ‐exposed and control groups. We conclude that acute CPZ exposure could lead to myocardial injury in rats, in which HSPs might play a crucial role. Further investigations are required to elucidate the underlying mechanisms.
Association between perceived social support and suicide ideation distress among psychiatric inpatients: The role of thwarted interpersonal needs
Authors: Sparks Sarah , Mitchell Sean M. , LeDuc Michael K. 
Published: February 2023

AbstractIntroductionThe interpersonal theory of suicide posits that thwarted belongingness (TB) and perceived burdensomeness (PB) are proximal risk factors for suicide ideation; however, there are mixed results regarding this hypothesis among psychiatric inpatients.ObjectiveThe current study examined the mediating role of TB and PB in the relationship between perceived social support (i.e., support from family, friends, a significant other, and total) and suicide ideation distress among psychiatric inpatients.MethodsParticipants (short‐term psychiatric inpatients; N = 139) were administered self‐report assessments cross‐sectionally.ResultsNonparametric mediation results indicated that the total (additive) indirect effects of TB and PB, in parallel, were significant in all models, yet there were only significant specific (unique) indirect effects of PB.ConclusionTB and PB, in combination, may be proximal risk factors for suicide ideation distress among psychiatric inpatients with lower perceived social support from family, friends, a significant other, and in total. These findings are congruent with the interpersonal theory of suicide's propositions that the combination of TB and PB increases the risk for suicide ideation. Clinicians may consider using interventions that target increasing perceived social support and decreasing TB and PB (i.e., cognitive behavioral therapy and social skills training) for this population.
Computational models of stimulus equivalence: An intersection for the study of symbolic behavior
Authors: Tovar Ángel Eugenio , Torres‐Chávez Álvaro , Mofrad Asieh Abolpour , Arntzen Erik 
Published: February 2023

AbstractStimulus equivalence is a central paradigm in the analysis of symbolic behavior, language, and cognition. It describes emergent relations between stimuli that were not explicitly trained and cannot be explained by primary stimulus generalization. In recent years, researchers have developed computational models to simulate the learning of equivalence relations. These models have been used to address primary theoretical and methodological issues in this field, such as exploring the underlying mechanisms that explain emergent equivalence relations and analyzing the effects of training and testing protocols on equivalence outcomes. Nonetheless, although these models build upon general learning principles, their operation is usually obscure for nonmodelers, and in the field of stimulus equivalence computational models have been developed with a variety of approaches, architectures, and algorithms that make it difficult to understand the scope and contributions of these tools. In this paper, we present the state of the art in computational modeling of stimulus equivalence. We seek to provide concise and accessible descriptions of the models' functioning and operation, highlight their main theoretical and methodological contributions, identify the existing software available for researchers to run experiments, and suggest future directions in the emergent field of computational modeling of stimulus equivalence.
Shell‐less culture system for chick embryos from the blastoderm stage to hatching
Authors: Dunn Bruce E. 
Published: February 2023

AbstractSince 2014, methods have been described to hatch chick embryos from shell‐less culture after egg contents are first incubated within shells for 55–70 h. The present report describes for the first time a shell‐less culture system for chick embryos from the blastoderm stage to hatching. For the first 69–70 h, egg contents suspended in polymethylpentene kitchen wrap (F.O.R. Wrap, Riken Fabro, Tokyo, Japan) supported in 6.35 or 6.67 cm inside diameter tripods and covered with a disc of immobilized Milli‐Wrap, were rotated back and forth through 90° at 16 or 22 cycles per minute (CPM). Subsequently, the Milli‐Wrap disc was removed and culture tripods were transferred to environmental chambers, which were rocked ±20° through incubation day 8.5 (E8.5). From E9, environmental chambers were maintained in the horizontal position through to hatching with controlled O2 and CO2. To provide supplemental calcium, an aqueous solution containing 100 mg/mL of calcium
l‐lactate hydrate was injected through the plastic wrap into the albumen at E9 (2.5 mL) and at E13 (1.0 mL) or E15 (1.0 mL). After incubation for 69–70 h at 16 or 22 CPM, 80%–83% of previously unincubated egg contents yielded apparently normal embryos. Hatch rate of normal embryos resulting from turntable incubation at 16 or 22 CPM was approximately 43%. Of note, egg contents remained in the same culture tripod from blastoderm stage to hatching. This technique may find use as an educational tool and in basic investigations of early embryogenesis, teratogenesis, and gene transfer experiments.
Regions of homozygosity confer a worse prognostic impact in myelodysplastic syndrome with normal karyotype
Authors: Mallo Mar , Tuechler Heinz , Arenillas Leonor , Raynaud Sophie , Cluzeau Thomas , Shih Lee‐Yung , Tung‐Liang Chiang , Ganster Christina , Shirneshan Katayoon , Haase Detlef , Mascaró Martí , Palomo Laura , Cervera José , Such Esperanza , Trim Nicola , Jeffries Sally , Ridgway Emma , Marconi Giovanni , Martinelli Giovanni , Solé Francesc 
Published: February 2023

AbstractHalf of the myelodysplastic syndromes (MDS) have normal karyotype by conventional banding analysis. The percentage of true normal karyotype cases can be reduced by 20–30% with the complementary application of genomic microarrays. We here present a multicenter collaborative study of 163 MDS cases with a normal karyotype (≥10 metaphases) at diagnosis. All cases were analyzed with the ThermoFisher® microarray (either SNP 6.0 or CytoScan HD) for the identification of both copy number alteration(CNA) and regions of homozygosity (ROH). Our series supports that 25 Mb cut‐off as having the most prognostic impact, even after adjustment by IPSS‐R. This study highlights the importance of microarrays in MDS patients, to detect CNAs and especially to detect acquired ROH which has demonstrated a high prognostic impact.
Analysis of urinary oligosaccharide excretion patterns by UHPLC/HRAM mass spectrometry for screening of lysosomal storage disorders
Authors: Hagemeijer Marne C. , van den Bosch Jeroen C. , Bongaerts Michiel , Jacobs Edwin H. , van den Hout Johanna M. P. , Oussoren Esmee , Ruijter George J. G. 
Published: February 2023

AbstractOligosaccharidoses, sphingolipidoses and mucolipidoses are lysosomal storage disorders (LSDs) in which defective breakdown of glycan‐side chains of glycosylated proteins and glycolipids leads to the accumulation of incompletely degraded oligosaccharides within lysosomes. In metabolic laboratories, these disorders are commonly diagnosed by thin‐layer chromatography (TLC) but more recently also mass spectrometry‐based approaches have been published. To expand the possibilities to screen for these diseases, we developed an ultra‐high‐performance liquid chromatography (UHPLC) with a high‐resolution accurate mass (HRAM) mass spectrometry (MS) screening platform, together with an open‐source iterative bioinformatics pipeline. This pipeline generates comprehensive biomarker profiles and allows for extensive quality control (QC) monitoring. Using this platform, we were able to identify α‐mannosidosis, β‐mannosidosis, α‐N‐acetylgalactosaminidase deficiency, sialidosis, galactosialidosis, fucosidosis, aspartylglucosaminuria, GM1 gangliosidosis, GM2 gangliosidosis (M. Sandhoff) and mucolipidosis II/III in patient samples. Aberrant urinary oligosaccharide excretions were also detected for other disorders, including NGLY1 congenital disorder of deglycosylation, sialic acid storage disease, MPS type IV B and GSD II (Pompe disease). For the latter disorder, we identified heptahexose (Hex7), as a potential urinary biomarker, in addition to glucose tetrasaccharide (Glc4), for the diagnosis and monitoring of young onset cases of Pompe disease. Occasionally, so‐called “neonate” biomarker profiles were observed in young patients, which were probably due to nutrition. Our UHPLC/HRAM‐MS screening platform can easily be adopted in biochemical laboratories and allows for simple and robust screening and straightforward interpretation of the screening results to detect disorders in which aberrant oligosaccharides accumulate.
Magnetic resonance imaging organ at risk delineation for nasopharyngeal radiotherapy: Measuring the effectiveness of an educational intervention
Authors: Ryan Olivia , Dundas Kylie , Surjan Yolanda , Elwadia Doaa , Nguyen Kimberley , Cardoso Michael , Kumar Shivani 
Published: February 2023

AbstractIntroductionMagnetic resonance imaging (MRI) demonstrates superior soft tissue contrast and is increasingly being used in radiotherapy planning. This study evaluated the impact of an education workshop in minimising inter‐observer variation (IOV) for nasopharyngeal organs at risk (OAR) delineation on MRI.MethodsTen observers delineated 14 OARs on 4 retrospective nasopharyngeal MRI data sets. Standard contouring guidelines were provided pre‐workshop. Following an education workshop on MRI OAR delineation, observers blinded to their original contours repeated the 14 OAR delineations. For comparison, reference volumes were delineated by two head and neck radiation oncologists. IOV was evaluated using dice similarity coefficient (DSC), Hausdorff distance (HD) and relative volume. Location of largest deviations was evaluated with centroid values. Observer confidence pre‐ and post‐workshop was also recorded using a 6‐point Likert scale. The workshop was deemed beneficial for an OAR if ≥50% of observers mean scores improved in any metric and ≥50% of observers' confidence improved.ResultsAll OARs had ≥50% of observers improve in at least one metric. Base of tongue, larynx, spinal cord and right temporal lobe were the only OARs achieving a mean DSC score of ≥0.7. Base of tongue, left and right lacrimal glands, larynx, left optic nerve and right parotid gland all exhibited statistically significant HD improvements post‐workshop (P < 0.05). Brainstem and left and right temporal lobes all had statistically significant relative volume improvements post‐workshop (P < 0.05). Post‐workshop observer confidence improvement was observed for all OARs (P < 0.001).ConclusionsThe educational workshop reduced IOV and improved observers' confidence when delineating nasopharyngeal OARs on MRI.
Influence of process conditions on the sulfonation of methyl ester synthesized from used cooking oil: Optimization by Taguchi approach
Authors: Bode‐Olajide Favour B. , Yusuff Adeyinka S. , Adesina Olusola A. , Adeniyi Adekunle T. 
Published: February 2023

AbstractDeveloping a robust and facile process route for fatty acid methyl ester sulfonate (MES) synthesis is of importance for industrial applications. Herein, Taguchi orthogonal array (OA) approach was used for the first time to establish the optimum process condition for the sulfonation of methyl esters (ME) with chlorosulfonic acid (CSA). According to the experimental design, the most significant parameter was sulfonation temperature, followed by CSA/ME molar ratio. Under the optimum sulfonation conditions (that is, 70°C sulfonation temperature, 2.0 h sulfonation time, 1.5:1 mol/mol CSA/ME molar ratio and 2.0 h aging time), the MES yield and the corresponding signal/noise ratio were 92.08 ± 0.28% and 39.28, respectively. The obtained FTIR and 1H NMR data revealed spectra associated with methyl (CH2 asymmetric and CH2 symmetric stretching vibrations), esters (CO, CO, and OCH3), and sulfonate (SO) groups in the MES sample synthesized under optimal conditions, thus confirming the target MES product. Surface tension measurements revealed that the optimal MES sample had a low critical miscelle concentration of 0.082 g/L at a surface tension of 51.2 mN/m, implying the possibility of better performance.
Kinetics of uncatalyzed oxidation of ammonium sulfite from wet ammonia desulfurization
Authors: Peng Jian , Yang Zhen , Lian Peichao 
Published: February 2023

AbstractThe kinetics of oxidation of ammonium sulfite from flue gas desulfurization by ammonia process was studied by changing initial ammonium sulfite concentration, pH, air flow rate, temperature, and concentration of ammonium sulfate in a bubble reactor. The experimental results show that the oxidation rate of ammonium sulfite decreased with the increase of pH but increased with the increase of temperature and airflow rate when the concentration of ammonium sulfate is 0.15 mol/L, temperature of 25–60°C, and an airflow rate of 150–400 L/h. When the concentration of ammonium sulfate increases from 0.2 to 1.0 mol/L, the oxidation rate of ammonium sulfite decreases. At pH 5.0, the activation energy of the apparent oxidation is 26.40 kJ/mol. A kinetics model containing SO32−, SO4, and O2 is used to simulate the oxidation of ammonium sulfate. The results can provide a theoretical basis for the uncatalyzed oxidation of ammonium sulfite in the process of wet ammonia desulfurization process.
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells
Authors: Wang Da‐Yong , Zhang Jing , Li Hai‐Xia , Zhang Yan‐Xia , Jing Mi‐Rong , Cai Chun‐Bo , Wang Di , Qi Hui‐Wen , Wang Yi‐Zhen , Chen Hao‐Jie , Li Tao , Zhai Yuan‐Kun , Ji Xin‐Ying , Wu Dong‐Dong 
Published: February 2023

AbstractHydrogen sulfide (H2S) has been widely recognized as one of gasotransmitters. Endogenous H2S plays a crucial role in the progression of cancer. However, the effect of endogenous H2S on the development of nasopharyngeal carcinoma (NPC) is still unknown. In this study, aminooxyacetic acid (AOAA, an inhibitor of cystathionine‐β‐synthase), dl‐propargylglycine (PAG, an inhibitor of cystathionine‐γ‐lyase), and l‐aspartic acid (l‐Asp, an inhibitor of 3‐mercaptopyruvate sulfurtransferase) were adopted to detect the role of endogenous H2S in NPC growth. The results indicated that the combine (PAG + AOAA + l‐Asp) group had higher inhibitory effect on the growth of NPC cells than the PAG, AOAA, and l‐Asp groups. There were similar trends in the levels of apoptosis and reactive oxygen species (ROS). In addition, the combine group exhibited lower levels of phospho (p)‐extracellular signal‐regulated protein kinase but higher expressions of p‐p38 and p‐c‐Jun N‐terminal kinase than those in the AOAA, PAG, and l‐Asp groups. Furthermore, the combine group exerted more potent inhibitory effect on NPC xenograft tumor growth without obvious toxicity. In summary, suppression of endogenous H2S generation could dramatically inhibit NPC growth via the ROS/mitogen‐activated protein kinase pathway. Endogenous H2S may be a novel therapeutic target in human NPC cells. Effective inhibitors for H2S‐producing enzymes could be designed and developed for NPC treatment.
On a thermo‐visco‐elastic model with nonlinear damping forces andL1temperature data
Authors: Owczarek Sebastian , Wielgos Karolina 
Published: February 2023

The aim of this paper is to prove the existence of weak solutions to thermo‐visco‐elastic system of equations. In considered problem, the temperature term is included in the elastic constitutive equations (generalized Hooke's law) as well as in describing the evolution of visco‐elastic strain. The main idea of presented proof is to analyze reformulated model, in which visco‐elastic strain (internal variable) is eliminated. For such system of equations, we propose a two‐level Galerkin approximation, which allows us to show a non‐negativity of temperature during the entire deformation process. In order to characterize the weak limits in the nonlinearities occurring in the system at different levels of approximation, the following tools are used: Truncation methods for heat equation proposed in the paper of D. Blanchard [Nonlinear Analysis, 21(10):725‐743, 1993], modified Boccardo‐Gallouët's approach, and Minty‐Browder trick.
Modeling clinical outcomes in radiotherapy: NTCP, TCP and the “TECs”
Authors: Yorke Ellen 
Published: February 2023

AbstractRadiation therapy is a double‐edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely have a unified understanding of the dosimetric and clinical correlates of the desired outcomes. I am fortunate to have participated in some of these struggles, including analyzing and using in‐house data and being involved in the AAPM and ASTRO “TEC” projects—QUANTEC (Quantitatie Analysis of Normal Tissue Effects in the Clinic), HyTEC (Hypofractionated Treatment Effects in the Clinic) and PENTEC (Pediatric Normal Tissue Effects in the Clinic).