bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent tectonism on Mercury revealed by a global population of small grabens
Authors: Man Benjamin , Rothery David , Balme Matthew , Conway Susan , Wright Jack 
Published: January 2023

Abstract
Since Mariner 10 first imaged Mercury in 1974, tectonic landforms, of which shortening structures dominate, have been well documented. Most tectonic structures on Mercury are thought to have formed, and been most active, early in the planet’s history but here we report the discovery of widespread young extensional grabens. These landforms occur as secondary tectonic features on larger, compressional tectonic structures and indicate continued activity of the parent structure. Extensional grabens are 10s to 100s of metres deep, tens of km in length and generally less than one kilometre wide. We calculate that they are ~300 million years old or younger, otherwise impact gardening would mask their signature. Together, the global distribution of extensional grabens and their young age provide compelling evidence that many of Mercury’s shortening structures have continued to move until geologically recent times.
Cancer Patients Circadian Rhythm Assessment Based on Morningness-Eveningness Preference
Authors: Daftari Ghazal , Rad Nasim khajavi , Abbaszadeh Mahsa , Reyhan Sahar Karimpour 
Published: January 2023

Abstract
Background
The circadian rhythm regulates various physiological processes, including cell division and cancer development. This study aimed to investigate circadian rhythm patterns in cancer patients.
Methods
In this cross-sectional study, 150 cancer patients admitted to the internal ward of Tehran’s Imam Khomeini Hospital Complex in the fall of 2021 were evaluated. The demographic characteristics of patients were collected using a checklist. Patients also completed a morningness-eveningness questionnaire (MEQ). Utilizing Analysis of Variance (ANOVA) and Fisher’s exact test, circadian rhythm types with continuous and categorical variables were compared.
Results
The mean age of the study’s participants was 49.83 ± 14.53 years. A total of 82.7% (n = 124) had non-hematological cancers, and breast cancer was the most prevalent type of cancer among patients (23.3%). The MEQ score of the patients ranged from 41 to 74, with a mean score of 56.6 ± 6.34 and neither type was the most common type.
conclusions
According to the findings of this study, the circadian rhythm is distributed normally among the participants.
Resilience capacities to reduce the impacts of natural disasters (flood)
Authors: Amirsadat Meysam , Omidipoor Kooresh , Bastaminia Amir , Meshkinghalam Mohammad Mehdi 
Published: January 2023

AbstractThe purpose of this study is to investigate and evaluate resilience capacities to reduce the impacts of natural disasters (floods) in Konarak city. This study is applied research, which uses descriptive-analytical method to identify and measure dimensions and components resilience of Konarak city. The sample size was estimated using Cochran's formula of 371 households in four neighborhoods of Shomal nirogah gazi, Surak, Nazarabad and Jonoob shahr of Konarak city. To conduct research, first by using library sources, indicators and factors affecting social, economic, institutional, physical, environmental, health-sanitary and individual resilience were identified, and then the field methods and questionnaire were used to collect the required information.In order to analyze the data, the coefficient of multiple correlations such as multiple regression analyses and path analysis were used. The results showed that the level of resilience in the Konarak city is in the social dimension 48.70, economic 38.61, institutional 41.56, physical 31.20, environmental 34.12, health-sanitary 27.48 and individual dimension 39.12, which were in an unfavourable situation. The highest level of resilience is related to the neighbourhoods Shomal nirogah gazi and Surak with 40.95 and 37.81%, respectively, and the lowest level of resilience is for the neighborhoods Nazarabad and Jonoob shahr with 34.22 and 36.05%, respectively. Also, path analysis of resilience shows that in relation to the direct effects of resilience, the social dimension has the highest effect with (0.56) and the next ranks are the economic dimension with (0.51), the environmental dimension (0.41), and the physical dimension (0.39). ), the individual dimension (0.37), the institutional dimension (0.13) and the health-sanitary dimension with (0.10) have influenced the resilience of Konark city. Regarding the indirect effects, social resilience has the highest (0.43) and institutional dimension has the lowest (0.04) indirect impact on the resilience of the sample neighbourhoods of Konarak city.
Multiple endocrine neoplasia may have an increased risk of other cancers？—Clinical characteristics of Multiple endocrine neoplasia type 1 or 2 patients with malignant tumors
Authors: Zhao Yu xing , Wang Ou , Song An , Wang Lin jie , Gong Feng ying , Duan Lian , Yang Hong bo , Pan Hui , Zhu Huijuan 
Published: January 2023

Abstract

Objective
We aim to summarized and analyzed characteristics of Multiple Endocrine Neoplasia type 1 (MEN-1) or Multiple Endocrine Neoplasia type 2 (MEN-2) cases with other malignant tumors which not belong to MEN components.
Methods
The clinical data from patients with MEN-1 or MEN-2 in Peking Union Medical College Hospital from April 2012 to April 2022 were collected. Mutations of MEN1or RET were identified by Sanger sequencing or MLPA in MEN-1 or MEN-2 patients who were diagnosed with malignant tumors which not belong to MEN-1 components.
Results
A total of 221 patients were diagnosed of MEN-1, in which, 23(11.61%) patients were found to have malignant tumors not belong to MEN-1 components, including papillary thyroid carcinoma (4.52%), breast cancer (1.81%), urologic neoplasms (1.35%), Primary hepatic carcinoma (0.09%), meningeal sarcoma(0.05%), glioblastoma(0.05%), cervical cancer (0.05%), lung carcinoma（0.05%. The prevalence of endocrine neoplasm especially gastroenteropancreatic neuroendocrine tumors were higher in MEN-1 patients with other malignant tumors compared to MEN-1 patients without malignant tumors. 76 patients were diagnosed of MEN-2, 2 (2.63%) patients were identified with papillary thyroid carcinoma and lung cancer respectively.
Conclusion
MEN-1 patients have a higher risk of developing malignant tumors than the general population, especially breast cancer, papillary thyroid carcinoma and urologic neoplasms. The specific mechanism is still unclear, but the clinical manifestations of MEN-1 patients with malignant tumors were more severe than those without malignant tumors.
Multispectral sensor fusion in SmartWatch for in situ continuous monitoring of human skin hydration and body sweat loss
Authors: Volkova Elena , Perchik Alexey , Pavlov Konstantin , Nikolaev Evgenii , Ayuev Alexey , Park Jaehyuck , Chang Namseok , Lee Wonseok , Kim Justin , Doronin Alexander , Vilenskii Maksim 
Published: January 2023

Abstract

Post-pandemic health operations have become a near-term reality, discussions around wearables are on the rise. How do wearable health solutions effectively deploy and use this opportunity to fill the gap between wellness and healthcare? In this paper, we will talk about taking a step further towards making wearable healthcare diagnosis closer to the reality, with a particular focus on monitoring skin hydration using optical multi-wavelength sensor fusion. Continuous monitoring of human skin hydration is a task of paramount importance for maintaining water loss dynamics for fitness lovers as well as for skin beauty, integrity and the health of the entire body. Preserving the appropriate levels of hydration ensures consistency of weight, positively affects psychological state, and proven to result in a decrease in blood pressure as well as the levels of "bad" cholesterol while slowing down the aging processes. Traditional methods for determining the state of water content in the skin do not allow continuous and non-invasive monitoring, which is required for variety of consumer, clinical and cosmetic applications. We present novel sensing technology and a pipeline for capturing, modeling and analyses of the skin hydration phenomena and associated changes therein. By expanding sensing capabilities built into the SmartWatch sensor and combining them with advanced modeling and Machine Learning algorithms, we identified several important characteristics of photoplethysmography (PPG) signal and spectral sensitivity corresponding to dynamics of skin water content. In a hardware aspect, we newly propose the exapntion of SmartWatch capabilities with InfraRed light sources equipped with specialized wavelengths of 970 nm and 1450 nm. Evaluation of the accuracy and characteristics of PPG sensors has been performed with biomedical optics-based simulation framework using Monte Carlo simulations. We performed rigorous validation of the developed technology using experimental and clinical studies. The developed pipeline serves as a tool in the ongoing studies of the next generation of optical sensing technology.
Repeatability coefficient for fruit quality and selection of mango hybrids using REML/BLUP analysis
Authors: Costa Cristina dos Santos Ribeiro , Costa Antonio Elton da Silva , Neto Francisco Pinheiro Lima , de Lima Maria Auxiliadora Coelho , Martins Luiza Suely Semen , Musser Rosimar dos Santos 
Published: January 2023

Abstract
Mango is a tropical fruit of significant economic, social, and nutritional importance. However, the low diversity of commercial mango orchards in Brazil highlights the need to broaden the genetic base of this crop. From this perspective, this study aimed to select mango genotypes for cultivation under semi-arid conditions using the mixed model methodology: restricted maximum likelihood/best linear unbiased prediction (REML/BLUP). Two hundred and ninety-two plants were evaluated over two crop seasons using fifteen traits related to fruit quality. The statistical analyses were performed with the software Selegen. The repeatability coefficient estimates (r) ranged from 0.06 to 0.97, and were considered high for most variables. The selective accuracy predicted by REML for the evaluated parameters ranged from 0.25 to 0.98, revealing a good degree of confidence in the inferences. For all evaluated traits there was a genetic gain with selection. Twelve genotypes were selected as the most promising using the minimum selection indices proposed in this study, showing higher mean values for all evaluated traits. These genotypes can be selected for new stages of the mango breeding program in the Brazilian semi-arid region.
Two-dimensional Kβ-Kα fluorescence spectrum by nonlinear resonant inelastic X-ray scattering
Authors: Tamasaku Kenji , Taguchi Munetaka , Inoue Ichiro , Osaka Taito , Inubushi Yuichi , Yabashi Makina , Ishikawa Tetsuya 
Published: January 2023

Abstract
High sensitivity of the Kβ fluorescence spectrum to electronic state is widely used to investigate spin and oxidation state of first-row transition-metal compounds. However, the complex electronic structure results in overlapping spectral features, and the interpretation may be hampered by ambiguity in resolving the spectrum into components representing different electronic states. Here, we tackle this difficulty with a new nonlinear resonant inelastic X-ray scattering (RIXS) scheme, where we leverage sequential two-photon absorption to realize an inverse process of the Kβ emission, and measure the successive Kα emission. The nonlinear RIXS reveals two-dimensional Kβ-Kα fluorescence spectrum of copper metal, leading to better understanding of the spectral feature. We isolate 3d-related satellite peaks in the two-dimensional spectrum, and find good agreement with our atomic multiplet calculation. Our work not only advances the fluorescence spectroscopy, but opens the door to extend RIXS into the nonlinear regime.
Insufficient Knowledge of Human Papilloma Virus among Reproductive-Aged Women from Arak, Iran
Authors: Fathi Parnia-Sadat , Sofian Masoomeh , Almasi-Hashiani Amir , Larijani Mona Sadat , Ashrafian Fatemeh , Ramezani Amitis 
Published: January 2023

Abstract
Background
Human papilloma virus (HPV) is the most common sexually transmitted infection worldwide. This study aimed at evaluation of women’s knowledge about HPV and HPV vaccine and identification of related factors conducted on 400 reproductive-aged women referred to health care centers in Arak, Iran.
Methods
A researcher-made questionnaire was applied to assess the participants’ knowledge regarding HPV and HPV vaccine among Iranian reproductive-aged women.
Results
Most participants were married (82%), diploma (34.6%), had two children (32.2%), and lived in an urban area (93%).The mean age among the studied population was 32.5 years. The associated HPV and vaccine knowledge were evaluated as insufficient in 86.5% and 79% of the participants, respectively. Out of 400, 37.5% and 34.5% of participants knew that the HPV vaccine protected against cervical cancer and genital warts, respectively. Our results revealed that the knowledge of the infection and its ways of protection were significantly higher in well-educated women. What is more, the awareness declined in those with more children in the family.
Conclusions
The level of understanding in terms of the incidence and also prevention was evaluated poor in our study. This highlights that further campaigns are required to improve it. Vaccination programs should be seriously considered to prevent HPV infection and its complications like cervical cancer.
Inferring Circadian Gene Regulatory Relationships from Gene Expression Data with a Hybrid Framework
Authors: Hu Shuwen , Yi Jing , Li Tao , Wang You-Gan , Liu Zhenyu , Gao Jing , Tian Yu-Chu 
Published: January 2023

Abstract
Background: The central biological clock controls countless aspects of mammalian physiology, such as sleep, metabolism, and immune system regulation. Gene regulatory relationships are essential in understanding the mechanisms that underlie various cellular biological processes. It is feasible to infer circadian gene regulatory relationships from time-series gene expression data. But the correlation-based inference of the relationships between genes does not provide sufficient information about causation. Moreover, gene expression data usually have low-sampling observations and high dimensions, leading to difficulties in gene data analysis.
Results: In this paper, we proposed a new hybrid framework to infer circadian gene regulatory relationships from gene expression data of rats. For practical clustering computation of the high-dimensional problem, the framework hybridizes the fuzzy C-means clustering algorithm and dynamic time warping (DTW) distance. After a cluster of genes is identified for the target gene, we conducted Wilcoxon signed-rank test to obtain the number of significant genes in the specific cluster. Finally, we applied a dynamic vector autoregressive method to the selected significant gene expression profiles to identify a directed causal regulatory relationship from partial correlation.
Conclusions: Circadian gene regulatory relationships are inferred from the gene expression data of rats based on the Aanat target gene. The results show that genes Pde10a, Atp7b, Prok2, Per1, Rhobtb3 and Dclk1 stand out, which have been known to be essential for the regulation of circadian behaviour. The potential relationships between genes Tspan15, Eprs, Eml5 and Fsbp with a circadian rhythm need further experimental research.
Culturally diverse facial expression signals diminish the precision of emotion communication across cultures
Authors: Chen Chaona , Messinger Daniel , Chen Cheng , Yan Hongmei , Duan Yaocong , Ince Robin , Garrod Oliver , Schyns Philippe , Jack Rachael 
Published: January 2023

Abstract
Communicating emotional intensity provides rich information both about the nature and likelihood of helpful or harmful behaviors. How human facial expressions achieve this complex signalling task remains unknown. Here, using the six classic emotions—happy, surprise, fear, disgust, anger, sad—in two distinct cultures (East Asian, Western European; total N = 120 individual observers), we mathematically modelled the specific facial movements that signal emotion categories and emotion intensity. In both cultures, specific facial movements cascade emotion category and intensity information over time via a distinct temporal structure. Cross-cultural analysis revealed systematic cultural variance in these facial signals that diminishes cross-culture communication but preserves communication of priority threat-related information. Together, our results provide new insights into how facial expressions can achieve complex signalling tasks via compositional and dynamic structures.
26.7% efficiency silicon heterojunction solar cells achieved by electrically optimized nanocrystalline-silicon hole contact layers
Authors: Lin Hao , Yang Miao , Ru Xiaoning , Wang Genshun , Yin Shi , Peng Fuguo , Hong Chengjian , Qu Minghao , Lu Junxiong , Fang Liang , Han Can , Procel Paul , Isabella Olindo , Gao Pingqi , Li Zhenguo , Xu Xixiang 
Published: January 2023

Abstract
Thanks to the prominent passivating contact structures, silicon heterojunction (SHJ) solar cell has recently achieved revolutionary advancements in the photovoltaic industry. This is, however, bound to further strengthen its contact performance for gaining the competitive edge in the period of technology transformation. Here, we developed SHJ cells with improved rear contact consisting of a p-type doped nanocrystalline silicon and a tailored transparent conductive oxide. Benefiting from the low contact resistance of hole-selective contacts (< 5 mΩ·cm2), a high power conversion efficiency of 26.74% together with a record filling factor (FF) of 86.48% were certified on industrial-grade silicon wafers (274 cm2, M6 size). The electrical properties of the modified SHJ cells were thoroughly analyzed in comparison with the normal p-type transporting layer counterparts (i.e., amorphous silicon), and the improved charge carrier transport in behind were also fully demonstrated.
Antibody responses against vaccine-preventable infectious diseases in HIV-exposed and unexposed Malawian infants
Authors: Baroncelli Silvia , Galluzzo Clementina Maria , Orlando Stefano , Pirillo Maria Franca , Luhanga Richard , Mphwere Robert , Kavalo Thom , Amici Roberta , Floridia Marco , Andreotti Mauro , Ciccacci Fausto , Scarcella Paola , Marazzi Maria Cristina , Giuliano Marina 
Published: January 2023

Abstract
Background
The evaluation of immunological status with respect to vaccine-preventable infectious diseases allows to identify populations with suboptimal protection. HIV-exposed infants, even if not infected with HIV, have higher morbidity and mortality in comparison to their unexposed counterparts, and even if the underlying mechanisms have not been clearly elucidated, dysfunctional immune responses might be involved. The aim of this study was to evaluate post-vaccination immune responses in two groups of infants (HIV-exposed and HIV-unexposed) living in the area of Blantyre, Malawi, measuring IgG levels against Haemophilus Influenzae type B (HiB), Hepatitis B (HBV), and Streptococcus pneumoniae (PCP).
Methods
Sixty-two infants, 49 HIV-exposed, uninfected (HEU), born to women living with HIV, and 13 HIV-unexposed, uninfected (HUU), born to HIV-negative mothers, were included in the study. The infants were visited monthly, from birth to 12 months, and blood samples were collected at 6 months. Anti-HiB, -HBV and -PCP vaccines are administered in Malawi at 6, 10, and 14 weeks of life. The antibody responses to the vaccines were determined by ELISA tests.
Results
The geometric mean concentrations (GMCs) of anti-HiB, anti-HBs and anti-PCP antibodies were not different between the two groups. The proportion of infants with protective levels (> 0.15 mg/l) versus HiB was lower (although not significantly) in HEU in comparison to HUU infants (81.6% vs 100%, p = 0.095). There was no significant difference between the two groups in the proportion of infants with protective antibody levels against HBV or PCP, although this proportion was lower than expected in both groups, varying from 81.6–84%. Overall, only 61.3% of the infants showed protective levels against all three vaccine antigens.
Conclusions
The humoral response after vaccination was similar in HEU and HUU infants. A disturbingly high proportion of infants without protective antibody levels against HBV and PCP in both groups of infants and against HiB in HEU infants was observed.
Both GEF domains of the autism and epilepsy-associated Trio protein are required for proper tangential migration of GABAergic interneurons
Authors: Rossignol Elsa , Eid Lara , Raju Praveen Kumar , Lokmane Ludmilla , Tadoum Samuel Boris Tene , Jiang Xiao , Toulouse Karolanne , Lupien-Meilleur Alexis , Charron-Ligez François , Toumi Asmaa , Backer Stephanie , Lachance Mathieu , Lavertu-Jolin Marisol , Montseny Marie , Lacaille Jean-Claude , Bloch-Gallego Evelyne 
Published: January 2023

Abstract

Recessive mutations in the TRIO gene are associated with intellectual deficiency (ID), autism spectrum disorder (ASD) and developmental epileptic encephalopathies (DEE). TRIO is a dual guanine nucleotide exchange factor (GEF) that activates Rac1, Cdc42 and RhoA. Trio has been extensively studied in excitatory neurons, and has recently been found to regulate the switch from tangential to radial migration in GABAergic interneurons (INs), through GEFD1-Rac1-dependent SDF1α/CXCR4 signalling. Given the central role of Rho-GTPases during neuronal migration and the implication of IN pathologies in ASD and DEE, we investigated the relative roles of both Trio’s GEF domains in regulating the dynamics of INs tangential migration. In Trio−/− mice, we observed reduced numbers of tangentially migrating INs, with intact progenitor proliferation. Further, we noted increased growth cone collapse in developing INs, suggesting altered cytoskeleton dynamics. To bypass the embryonic mortality of Trio−/− mice, we generated Dlx5/6Cre;Trioc/c conditional mutant mice, which develop spontaneous seizures and behavioral deficits reminiscent of ASD and ID. These phenotypes are associated with reduced cortical IN density and functional cortical inhibition. Mechanistically, this reduction of cortical IN numbers reflects a premature switch to radial migration, with an aberrant early entry in the cortical plate, as well as major deficits in cytoskeletal dynamics, including enhanced leading neurite branching and slower nucleokinesis reflecting reduced actin filament condensation and turnover. Further, we show that both Trio GEFD1 and GEFD2 domains are required for proper IN migration, with a dominant role of the RhoA-activating GEFD2 domain. Altogether, our data show a critical role of the DEE/ASD-associated Trio gene in the establishment of cortical inhibition and the requirement of both GEF domains in regulating IN migration dynamics.