bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micellization thermodynamics as a function of the temperature of a cationic zwitterionic dodecyl phosphocholine and anionic sodium dodecyl sulfate mixed micelles with fluorometry
Authors: Abo Gabal Raghda , Osama Sabreen , Hanafy Nemany , Oraby Ahmed 
Published: February 2023

AbstractAs fluorescence parameters such as lifetime, quantum yield, anisotropy and polarisation quantum are extremely sensitive to fluorophores’ microenvironmental changes, changes in the properties of the fluorescence probe have been widely used to study hydrophobic interactions in protein and membrane biology. The current study determines the critical micelle concentration (CMC) of mixed micelles of sodium dodecyl sulfate (SDS) and cationic surfactant N-dodecyl phosphocholine (DPC) based on fluorescence intensity measurements. biomolecular structure analysis and dynamics revealed through the measure of changes in the nanosecond time range. As the temperature rises, the onset of micellization tends to occur at higher concentrations. It was measured versus micelle concentration over a temperature range of (288–338) K. The obtained results were used to estimate the micellization thermodynamic parameters. Surfactant CMC drops to a minimum (T = 308 K) and then rises with temperature forming a parabolic curve as a function of temperature, according to experimental data. The CMCs are first correlated by a polynomial equation to determine the enthalpy of micellization. Both $$\Delta {H}_{\mathrm{mic}}$$

Δ

H
mic

and $$\Delta {S}_{\mathrm{mic}}$$

Δ

S
mic

appear to decrease monotonically as temperature rises. ΔGmic is negative, indicating that the micellization process is exothermic and favorable. The compensation temperature (Tc) ranged from (313–318) K by linear regression over the whole temperature range and for DPC, SDS, and mixed micelles together.
Association between graded subchorionic hematoma and adverse pregnancy outcomes in singleton pregnancies: a prospective observational cohort study
Authors: Liang Weizhang , Yan Xi , Shi Yifu , Chen Bingjun , An Luwan , Huang Bei , He Fang 
Published: February 2023

Abstract
Objective
To investigate whether different grades of subchorionic hematoma (SCH) are involved in the timing of birth and the development of adverse pregnancy outcomes in singleton pregnant women.

Methods
A total of 171 women with singleton pregnancies, 72 of whom had SCH before 20 weeks and between 12 and 20 weeks of gestational age (GA), were included in this study conducted between January 2018 and December 2021. These patients were divided into three subgroups based on the size of the subchorionic hematoma on ultrasound imaging. Baseline demographic data, obstetric outcomes, and risk factors for subchorionic hematoma were compared for the two groups.

Results
A higher number of pregnancies from the SCH group resulted in miscarriage (30.56% versus 2.02%, p < 0.0001), early preterm birth (8.33% versus 1.01%, p = 0.0035), premature rupture of membranes (15.28% versus 4.04%, p = 0.0103), fetal growth restriction (9.72% versus 0%, p = 0.0015), and delivery 13.18 days earlier (274.34 ± 11.25 versus 261.16 ± 29.80, p = 0.0013) than those from the control group. Compared with SCH detected before 12 weeks of GA, the rate of miscarriage increased, and the live birth rate decreased significantly in patients with SCH caught between 12 and 20 weeks of GA. With the increase in hematoma size, the likelihood of miscarriage increased significantly. Further analysis found that delivery occurred earlier in the medium/large SCH group (271.49 ± 23.61 versus 253.28 ± 40.68/261.77 ± 22.11, p = 0.0004/0.0073) but not in the small SCH group (274.34 ± 11.25 versus 267.85 ± 21.01, p = 0.2681) compared to the control group. Our results also showed that the anterior placenta (52.04% versus 33.33%, p = 0.0005, OR = 0.3137, 95% CI [0.1585, 0.601]) is a protective factor for subchorionic hematoma.

Conclusion
Our study shows that women with SCH are at a higher risk of adverse pregnancy outcomes and are independently associated with miscarriage, early preterm birth, premature rupture of membranes, and fetal growth restriction. A subchorionic hematoma, especially detected between 12 and 20 weeks of GA, is very likely to cause miscarriage or preterm birth in women with a medium or large subchorionic hematoma.
Prevalence and Severity Distribution of Type 2 Inflammation-Related Comorbidities Among Patients with Asthma, Chronic Rhinosinusitis with Nasal Polyps, and Atopic Dermatitis
Authors: Khan Asif H. , Gouia Imène , Kamat Siddhesh , Johnson Robert , Small Mark , Siddall James 
Published: February 2023

AbstractThis observational study assessed the prevalence of co-existing type 2 inflammatory conditions [T2Cs; asthma, atopic dermatitis (AD), allergic rhinitis, and chronic rhinosinusitis with nasal polyps (CRSwNP)] in patients with moderate-to-severe (M/S) type 2 asthma, M/S CRSwNP, or M/S AD, in the real-world setting. Data from 761 physicians in the US and EUR5 were sourced from Adelphi Disease-Specific Programmes covering patients with M/S asthma (n = 899), M/S CRSwNP (n = 683), and M/S AD (n = 1497). At least one T2C was identified in 66%, 69%, and 46% of M/S asthma, M/S CRSwNP, and M/S AD cohorts, respectively, and 24%, 36% and 16% had at least two T2Cs; trends were similar in the US and EUR5. In patients with M/S asthma or M/S CRSwNP, T2Cs commonly presented as mild or moderate. The comorbidity burden suggests that an integrated treatment approach is warranted to address underlying type 2 inflammation in patients with M/S type 2 diseases.
Sr–Pb isotope differences in pre- and post-burial human bone, teeth, and hair keratin: implications for isotope forensics
Authors: Kootker Lisette M. , Ammer Saskia T. M. , Wescott Daniel J. , Davies Gareth R. , Mickleburgh Hayley L. 
Published: February 2023

AbstractThe isotopic signatures of human tissues can provide valuable information on geographic origin for medicolegal investigations involving unidentified persons. It is important to understand the impact of diagenetic processes on isotopic signatures, as alterations could result in incorrect estimation of geographic origin. This study examines alterations in isotope signatures of different tissues of five human body donors studied throughout decomposition at the Forensic Anthropology Research Facility (FARF), San Marcos, TX. Two body donors were buried, two were placed in open pits, and one was first allowed to naturally mummify and then buried. Remains were recovered after a period of 7–34 months. The preplacement and post-recovery Sr–Pb isotope data of scalp hair, bone (iliac and tibia), and tooth enamel and dentine were compared. The hair samples record significant shifts in Sr-Pb isotope compositions, with hair keratin Pb isotope composition shifting towards the Pb signature of local soil samples. Hair keratin Sr isotope compositions were altered by the burial environment and possibly also by the lab sample cleaning method. The spongy iliac bone samples show inconsistencies in the recoverability of the preplacement Sr–Pb isotope signatures. The post-placement signatures of the buried donors show slight elevation over preplacement signatures. The post-placement signatures of donors placed in open pits are significantly elevated. The tibia and dental samples record the most consistent isotopic data with the least alteration. These more densely mineralised elements show good recoverability of the preplacement isotope signatures in burials and open pits and are thus deemed better targets for forensic investigative purposes.
Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis
Authors: Mourino Nerea , Varela-Lema Leonor , Ahluwalia Jasjit S. , Rey-Brandariz Julia , Candal-Pedreira Cristina , Ruano-Ravina Alberto , Vila-Farinas Andrea , Torres Andrés , Pérez-Rios Mónica 
Published: February 2023

AbstractArterial hypertension during childhood or adolescence is rising, and smoking during pregnancy may constitute a modifiable risk factor. This study aims to evaluate the effect of maternal smoking during pregnancy on diastolic (DBP) and systolic blood pressure (SBP) in childhood and adolescence. A bibliographic search was conducted in PubMed, Embase, and CENTRAL databases in March 2022. Meta-analysis was performed with the difference in mean-adjusted SBP/DBP of children and adolescents aged 3–17 years, according to maternal smoking/non-smoking in pregnancy. A random effects model was applied; a leave-one-out analysis and meta-analysis by subgroups were performed. A modified Newcastle–Ottawa scale was used to assess the quality of the studies. Evidence levels were rated using the GRADE system. Fifteen studies were included in the meta-analysis; all of them evaluated the mean-adjusted SBP difference in children or adolescents (N = 73,448), and 6 also that of DBP (N = 31,459). Results showed that maternal smoking during pregnancy significantly increased SBP (β = 0.31 mmHg 95% CI 0.14–0.49). A greater increase in mean-adjusted SBP was observed in those studies that completed the recruitment before 1990, were conducted in non-European countries, used standard mercury or manual sphygmomanometry, adjusted for birth weight, and were in the lowest quality subgroup. No significant association was found for DBP. The GRADE level of evidence was low for SBP and very low for DBP.Conclusion: Smoking in pregnancy might increase SBP in childhood and adolescence. Due to the low level of evidence, solid inferences cannot be drawn about the clinical relevance of these findings.

What is Known:• AHT is the leading cause of premature death among adults worldwide.• Deleterious effects derived from SHS exposure on children's health have been documented since early 1970. To date, there are contradictory results about the effects of prenatal SHS exposure on children’s BP.

What is New:• Smoking in pregnancy may increase SBP during childhood and adolescence.• Maternal smoking during pregnancy could have greater influence on their offspring's SBP than on DBP.
Evaluation of emotional dynamics in social media conversations: an approach based on structures of opposition and set-theoretic measures
Authors: Gaeta Angelo 
Published: February 2023

AbstractThe paper presents the results related to the definition and adoption of structures of opposition, built with set-theoretic measures, to evaluate emotional dynamics that arise during conversations on social media. Specifically, a graded hexagon of opposition is used to compare the emotional profiles of individuals involved in a dyadic conversation. Set-theoretic measures, based on fuzzy logic, are used to construct the hexagon whose analysis allows us to understand the tendency of the conversation toward empathy or lack of empathy. The results can be useful in the context of the current trend of social media sensing and, in particular, to support social media providers in receiving early warnings related to the analysis of emotional dynamics that could lead to or degenerate into information disorder. The results have been evaluated with conversations extracted from the Empathetic Dialogue dataset.
Multi-classification for EEG motor imagery signals using data evaluation-based auto-selected regularized FBCSP and convolutional neural network
Authors: An Yang , Lam Hak Keung , Ling Sai Ho 
Published: February 2023

AbstractIn recent years, there has been a renewal of interest in brain–computer interface (BCI). One of the BCI tasks is to classify the EEG motor imagery (MI). A great deal of effort has been made on MI classification. What seems to be lacking, however, is multiple MI classification. This paper develops a single-channel-based convolutional neural network to tackle multi-classification motor imagery tasks. For multi-classification, a single-channel learning strategy can extract effective information from each independent channel, making the information between adjacent channels not affect each other. A data evaluation method and a mutual information-based regularization parameters auto-selection algorithm are also proposed to generate effective spatial filters. The proposed method can be used to tackle the problem of an inaccurate mixed covariance matrix caused by fixed regularization parameters and invalid training data. To illustrate the merits of the proposed methods, we used the tenfold cross-validation accuracy and kappa as the evaluation measures to test two data sets. BCI4-2a and BCI3a data sets have four mental classes. For the BCI4-2a data set, the average accuracy is 79.01%, and the kappa is 0.7202 using data evaluation-based auto-selected filter bank regularized common spatial pattern voting (D-ACSP-V) and single-channel series convolutional neural network (SCS-CNN). Compared to traditional FBRCSP, the proposed method improved accuracy by 7.14% for the BCI4-2a data set. By using the BCI3a data set, the proposed method improved accuracy by 9.54% compared with traditional FBRCSP, the average accuracy of the proposed method is 83.70%, and the kappa is 0.7827.
The effect of various options for decompression of degenerated lumbar spine motion segments on the range of motion: a biomechanical in vitro study
Authors: Lener Sara , Schmölz Werner , Abramovic Anto , Kluger Patrick , Thomé Claudius , Hartmann Sebastian 
Published: February 2023

Abstract
Background
Lumbar spinal stenosis is a common disease in the aging population. Decompression surgery represents the treatment standard, however, a risk of segmental destabilization depending on the approach and extent of decompression is discussed. So far, biomechanical studies on techniques were mainly conducted on non-degenerated specimens. This biomechanical in vitro study aimed to investigate the increase in segmental range of motion (ROM) depending on the extent of decompression in degenerated segments.

Methods
Ten fresh frozen lumbar specimens were embedded in polymethyl methacrylate (PMMA) and loaded in a spine tester with pure moments of ± 7.5 Nm. The specimens were tested in their intact state for lateral bending (LB), flexion/extension (FE) and axial rotation (AR). Subsequently, four different decompression techniques were performed: unilateral interlaminar decompression (DC1), unilateral with "over the top" decompression (DC2), bilateral interlaminar decompression (DC3) and laminectomy (DC4). The ROM of the index segment was reported as percent (%) of the native state.

Results
Specimens were measured in their intact state prior to decompression. The mean ROM was defined as 100% (FE:6.3 ± 2.3°; LB:5.4 ± 2.8°; AR:3.0 ± 1.6°). Interventions showed a continuous ROM increase: FE (DC1: + 4% ± 4.3; DC2: + 4% ± 4.5; DC3: + 8% ± 8.3;DC4: + 20% ± 15.9), LB(DC1: + 4% ± 6.0; DC2: + 5% ± 7.3; DC3: + 8% ± 8.3; DC4: + 11% ± 9.9), AR (DC1: + 7% ± 6.0; DC2: + 9% ± 7.9; DC3: + 15% ± 11.5; DC4: + 19% ± 10.5). Significant increases in ROM for all motion directions (p < 0.05) were only obtained after complete laminectomy (DC4).

Conclusion
Unilateral and/or bilateral decompressive surgery resulted in a statistically insignificant ROM increase, whereas complete laminectomy showed statistically significant ROM increase. If this ROM increase also has an impact on the clinical outcome and how to identify segments at risk for secondary lumbar instability should be evaluated in further studies.
Neurological soft signs are increased in major depressive disorder irrespective of treatment
Authors: Schülke Rasmus , Liepach Kyra , Brömstrup Anna Lena , Folsche Thorsten , Deest Maximilian , Bleich Stefan , Neyazi Alexandra , Frieling Helge , Maier Hannah B. 
Published: February 2023

AbstractThe significance of neurological soft signs (NSS) in major depressive disorder (MDD) remains unclear and the stability of NSS in relation to antidepressant treatment has never been investigated. We hypothesized that NSS are relatively stable trait markers of MDD. We thus predicted that patients show more NSS than healthy controls, irrespective of illness duration and antidepressant treatment. To test this hypothesis, NSS were assessed in chronically depressed, medicated MDD patients before (n = 23) and after (n = 18) a series of electroconvulsive therapy (ECT). In addition, NSS were assessed once in acutely depressed, unmedicated MDD patients (n = 16) and healthy controls (n = 20). We found that both chronically depressed, medicated MDD patients and acutely depressed, unmedicated MDD patients showed more NSS than healthy controls. The degree of NSS in both patient groups did not differ. Importantly, we found no change in NSS after on average eleven sessions of ECT. Thus, the manifestation of NSS in MDD seems to be independent of illness duration and pharmacological and electroconvulsive antidepressant treatment. From a clinical perspective, our findings corroborate the neurological safety of ECT.
Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA
Authors: Hajdu Bálint , Hunyadi-Gulyás Éva , Kato Kohsuke , Kawaguchi Atsushi , Nagata Kyosuke , Gyurcsik Béla 
Published: February 2023

Abstract
Zinc finger proteins specifically recognize DNA sequences and, therefore, play a crucial role in living organisms. In this study the Zn(II)-, and DNA-binding of 1MEY#, an artificial zinc finger protein consisting of three finger units was characterized by multiple methods. Fluorimetric, circular dichroism and isothermal calorimetric titrations were applied to determine the accurate stability constant of a zinc finger protein. Assuming that all three zinc finger subunits behave identically, the obtained thermodynamic data for the Zn(II) binding were ΔHbinding site =  − (23.5 − 28.0) kcal/mol (depending on the applied protonation state of the cysteines) and logβ’pH 7.4 = 12.2 ± 0.1, being similar to those of the CP1 consensus zinc finger peptide. The specific DNA binding of the protein can be characterized by logβ’pH 7.4 = 8.20 ± 0.08, which is comparable to the affinity of the natural zinc finger proteins (Sp1, WT1, TFIIIA) toward DNA. This value is ~ 1.9 logβ’ unit higher than those determined for semi- or nonspecific DNA binding. Competitive circular dichroism and electrophoretic mobility shift measurements revealed that the conditional stability constant characteristic for Zn(II) binding of 1MEY# protein increased by 3.4 orders of magnitude in the presence of its target DNA sequence.

Graphical abstract
Rigidity results for Riemannian twistor spaces under vanishing curvature conditions
Authors: Catino G. , Dameno D. , Mastrolia P. 
Published: February 2023

AbstractIn this paper, we provide new rigidity results for four-dimensional Riemannian manifolds and their twistor spaces. In particular, using the moving frame method, we prove that $$\mathbb {C}\mathbb {P}^3$$

C

P

3

is the only twistor space whose Bochner tensor is parallel; moreover, we classify Hermitian Ricci-parallel and locally symmetric twistor spaces and we show the nonexistence of conformally flat twistor spaces. We also generalize a result due to Atiyah, Hitchin and Singer concerning the self-duality of a Riemannian four-manifold.
Combining multiple lines of evidence to elucidate the origin and introduction pathway of bitou bush (Chrysanthemoides monilifera subsp. rotundata) in Australia
Authors: Emmett Amanda M. , Scott John K. , Webber Bruce L. , Severn-Ellis Anita A. , Bell Karen L. 
Published: February 2023

AbstractUnderstanding the historical context of biological invasions can improve weed management outcomes. In this study, we aim to identify the introduction pathway of bitou bush (Chrysanthemoides monilifera subsp. rotundata) into Australia and its biogeographical origin in southern Africa by combining multiple lines of evidence from genomic tools and historical documentation. Geographic structure of genomic diversity based on SNPs supported the previous analysis of the invasion pathway of bitou bush between the two countries and within Australia, namely that all Australian material originated from the southern part of the South African distribution. Our synthesis of historical records points to the introduction of this plant into eastern Australia in Newcastle, New South Wales, from its native range in South Africa, via dry shipping ballast in about 1900. Variation in the chloroplast genome was also informative as to the biogeographical origin of Australian material and the context of the introduction. Ten unique haplotypes were discovered in South Africa with only one occurring throughout Australia, indicating an introduction from a single source population to eastern Australia. The matching haplotype was from East London, a port in South Africa with documented shipping connections to Newcastle in eastern Australia, where the weed was first recorded. Historical records suggest that the most plausible explanation for the origins of the isolated bitou bush population in Western Australia is via the shipping of steel billets or landscape plantings associated with shipping companies. The most likely introduction pathway linked the eastern Australian steel processing ports of Newcastle or Port Kembla to the Western Australian port of Kwinana in 1995. Discovering the origin and pathway of bitou bush invasions in Australia opens new opportunities for sourcing biological control agents with a higher chance of impact as well as identifying additional quarantine measures to improve outcomes and reduce long-term costs to management.
Formal Ethics, Content Ethics and Relational Ethics: Three Approaches to Constructing Ethical Sales Cultures and Identities in Retail Banking
Authors: Svane Marita Susanna , Frandsen Sanne 
Published: February 2023

AbstractFollowing the global financial crisis, banks have become more regulated to advance ethical sales cultures throughout the sector. Based on case studies of three retail banks, we find that they construct the ‘appropriate advisor’ in different ways. Inspired by Bakhtin’s work on ethics, we propose a vocabulary of relational ethics centered on the ‘answerable self.’ We argue that this vocabulary is apt for studying and discussing how organizations advance ethical sales cultures in ways that instead of encouraging value congruence and alignment allow for ethical openness. In such cultures, employees—as moral agents—are morally questioning, critically self-reflexive, and answerable for their own actions toward others in their social relationships. Our paper makes three theoretical contributions, namely, problematizing the idea of cultural alignment and value congruence, demonstrating that identity regulation can both comprise and support the ‘answerable self,’ and advancing our understanding of the interdependence of ethical openness and ethical closure in fostering ethical sales cultures.
Fibulorhizoctonia psychrophila, causal agent of lenticel spot in pome fruit, rarely detected in Dutch pear and apple orchards
Authors: Köhl J. , Haas B. H. Groenenboom-de , Wenneker M. 
Published: February 2023

Abstract
Fibulorhizoctonia psychrophila causes lenticel spot in stored pome fruit. A Dutch survey revealed that damage can be observed regularly in individual lots at low incidence to occasionally incidences above 25% after storage for five months or longer under specific controlled atmosphere storage conditions. The source of inoculum of the psychrophilic pathogen is not known. A species-specific TaqMan PCR assay was developed to quantify the pathogen DNA in orchard litter considered as potential inoculum source. 2008 samples of various litter types such as dead leaves, fallen fruits and mummies and necrotic tissues of grasses and weeds, collected in 2009–2012 in ten apple and twenty pear orchards, were analyzed. Although other fruit rot pathogens such as Neofabraea alba, Cadophora luteo-olivacea and Stemphylium vesicarium were detected in the samples at high incidences in earlier studies, F. psychrophila was only detected in three samples. The results show that F. psychrophila is not ubiquitously present in Dutch orchards at traceable concentrations. The main sources of the disease remain unknown. Possibly, the pathogen is present on storage bins or dust in storage facilities.