bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole genome sequencing and analysis of multiple isolates of Ceratocystis destructans, the causal agent of Ceratocystis canker of almond in California
Authors: Maguvu Tawanda E. , Travadon Renaud , Cantu Dario , Trouillas Florent P. 
Published: September 2023

AbstractCeratocystis canker caused by Ceratocystis destructans is a severe disease of almond, reducing the longevity and productivity of infected trees. Once the disease has established in an individual tree, there is no cure, and management efforts are often limited to removing the infected area of cankers. In this study, we present the genome assemblies of five C. destructans isolates isolated from symptomatic almond trees. The genomes were assembled into a genome size of 27.2 ± 0.9 Mbp with an average of 6924 ± 135 protein-coding genes and an average GC content of 48.8 ± 0.02%. We concentrated our efforts on identifying putative virulence factors of canker pathogens. Analysis of the secreted carbohydrate-active enzymes showed that the genomes harbored 83.4 ± 1.8 secreted CAZymes. The secreted CAZymes covered all the known categories of CAZymes. AntiSMASH revealed that the genomes had at least 7 biosynthetic gene clusters, with one of the non-ribosomal peptide synthases encoding dimethylcoprogen, a conserved virulence determinant of plant pathogenic ascomycetes. From the predicted proteome, we also annotated cytochrome P450 monooxygenases, and transporters, these are well-established virulence determinants of canker pathogens. Moreover, we managed to identify 57.4 ± 2.1 putative effector proteins. Gene Ontology (GO) annotation was applied to compare gene content with two closely related species C. fimbriata, and C. albifundus. This study provides the first genome assemblies for C. destructans, expanding genomic resources for an important almond canker pathogen. The acquired knowledge provides a foundation for further advanced studies, such as molecular interactions with the host, which is critical for breeding for resistance.
Renal histopathological predictors of end-stage kidney disease in ANCA-associated vasculitis with glomerulonephritis: a single-centre study in Korea
Authors: Choi Sung-Eun , Lee Soo Bin , Pyo Jung Yoon , Ahn Sung Soo , Song Jason Jungsik , Park Yong-Beom , Lim Beom Jin , Lee Sang-Won 
Published: September 2023

AbstractThis study investigated whether histopathological classification and histologic lesion scores could significantly and independently predict the progression to end-stage kidney disease (ESKD) in Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis-glomerulonephritis (AAV-GN). This study included 113 patients with AAV-GN confirmed by kidney biopsy. The glomerular, tubulointerstitial, and vascular lesions were systematically assessed using a scoring system. The scoring system was adopted from the Banff scoring system but also the Oxford study and the revision of the ISN/RPS. For comparison, the scores were classified into two groups; the low, and the high, and the difference was investigated between ESKD and non-ESKD groups using Cox proportional analysis. At diagnosis, the median age was 59.0 years and 33.6% were males. Of 113 patients, 44.2% had ESKD progression during follow-up. There were significant differences in several kidney-, inflammation-, and AAV-pathogenesis-related variables between AAV-GN patients with ESKD and those without. The sclerotic class exhibited the worst renal prognosis among the four histopathological classes. Among histopathological features, high interstitial fibrosis, tubular atrophy and global glomerulitis scores were significantly associated with ESKD progression. Whereas multivariable Cox analysis revealed only a high global glomerulitis score which means global endocapillary hypercellularity in a larger number of glomeruli is an independent predictor of ESKD progression. Moreover, among clinical and histopathological features, a high global glomerulitis score could also predict ESKD progression in addition to serum blood urea nitrogen and creatinine. This study demonstrated the worst renal prognosis for the sclerotic class and first discovered that a high global glomerulitis score was an independent predictor of ESKD in patients with AAV-GN.
Randomized phase-III study of low-dose cytarabine and etoposide + /− all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia
Authors: Schlenk R. F. , Weber D. , Krzykalla J. , Kindler T. , Wulf G. , Hertenstein B. , Salih H. R. , Südhoff T. , Krauter J. , Martens U. , Wessendorf S. , Runde V. , Tischler H. J. , Bentz M. , Koller E. , Heuser M. , Thol F. , Benner A. , Ganser A. , Döhner K. , Döhner H. 
Published: September 2023

AbstractThe aim of this randomized clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with non-intensive chemotherapy in older unfit patients (> 60 years) with newly diagnosed NPM1-mutated acute myeloid leukemia. Patients were randomized (1:1) to low-dose chemotherapy with or without open-label ATRA 45 mg/m2, days 8–28; the dose of ATRA was reduced to 45 mg/m2, days 8–10 and 15 mg/m2, days 11–28 after 75 patients due to toxicity. Up to 6 cycles of cytarabine 20 mg/day s.c., bid, days 1–7 and etoposide 100 mg/day, p.o. or i.v., days 1–3 with (ATRA) or without ATRA (CONTROL) were intended. The primary endpoint was overall survival (OS). Between May 2011 and September 2016, 144 patients (median age, 77 years; range, 64–92 years) were randomized (72, CONTROL; 72, ATRA). Baseline characteristics were balanced between the two study arms. The median number of treatment cycles was 2 in ATRA and 2.5 in CONTROL. OS was significantly shorter in the ATRA compared to the CONTROL arm (p = 0.023; median OS: 5 months versus 9.2 months, 2-years OS rate: 7% versus 10%, respectively). Rates of CR/CRi were not different between treatment arms; infections were more common in ATRA beyond treatment cycle one. The addition of ATRA to low-dose cytarabine plus etoposide in an older, unfit patient population was not beneficial, but rather led to an inferior outcome.The clinical trial is registered at clinicaltrialsregister.eu (EudraCT Number: 2010-023409-37, first posted 14/12/2010).
Salt and Aldosterone – Reciprocal and Combined Effects in
Preclinical Models and Humans
Authors: Chen Li , Adolf Christian , Reincke Martin , Schneider Holger 
Published: September 2023

AbstractPrimary aldosteronism is an endocrine disorder caused by excessive production of
aldosterone by the adrenal glands, and is recognized as the most important cause
of endocrine hypertension. With specific therapy, this type of hypertension is
potentially curable. In the general population, high salt intake increases the
risk for cardiovascular diseases like stroke. In populations with aldosterone
excess, observational and experimental data suggest that aldosterone-induced
organ damage requires a combination of high dietary salt intake and high plasma
aldosterone, i.e., plasma aldosterone levels inappropriately high for salt
status. Therefore, understanding the relationship between plasma aldosterone
levels and dietary salt intake and the nature of their combined effects is
crucial for developing effective prevention and treatment strategies. In this
review, we present an update on findings about primary aldosteronism and salt
intake and the underlying mechanisms governing their interaction.
Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the “Connection Trial”
Authors: Neu Josef , Ashley Patricia , Chowdhary Vikas , Lampland Andrea , Porcelli Peter , Rothstein Robert , Slancheva Boriana , Kronström Anders , Rastad Jonas , Strömberg Staffan , Thuresson Marcus ,   The Connection Study Group
Published: September 2023

Objective Investigate daily feeding volumes and their association with clinical variables in the early postnatal care of premature infants of the “Connection Trial.”
Study Design A total of 641 infants of 510 to 1,000-g birth weight (BW, mean: 847 g) and mean 27 weeks' gestational age at birth (GA) were analyzed for total daily enteral (TDE) feeding volumes of 10, 20, 40, 80, and 120 mL/kg/d and their association with 24 clinical variables. Uni- and multivariable Cox regression models were used to calculate hazard ratios (HR) with 95% confidence intervals as a measure of the chance of reaching each of the TDE volumes.
Results Daily feeding volumes were highly variable and the median advancement from 10 to 120 mL/kg/d was 11 mL/kg/d. Univariable analyses showed the lowest chance (HR, 0.22–0.81) of reaching the TDE volumes for gastrointestinal (GI) serious adverse events (SAEs), GI perforation, GI obstruction, and necrotizing enterocolitis, as well as respiratory SAEs, persistent ductus arteriosus, and hypotension. Each GA week, 100-g BW, and point in 5-minute Apgar score at birth associated with 8 to 20% increased chance of reaching the TDE volumes. Multivariable analyses showed independent effects for BW, GA, Apgar score, GI SAEs, abdominal symptoms/signs, respiratory SAEs, days on antibiotics, and hypotension.
Conclusion This observational analysis demonstrates the variable and cautious progression of enteral feedings in contemporary extremely low BW infants and the extent to which clinical variables associate with this progression.
Key Points
Non-adiabatic dissociation dynamics of Ar⋯I2 (E, v) intermolecular vibrational levels probed using velocity-map imaging
Authors: Makarem Camille , Loomis Richard A. 
Published: September 2023

Ion time-of-flight velocity-map imaging was used to measure the kinetic-energy distributions of the I2 ion-pair fragments formed after photoexcitation of Ar⋯I2 complexes to intermolecular vibrational levels bound within the Ar + I2 (E, vE = 0–2) potential energy surfaces. The kinetic-energy distributions of the I2 products indicate that complexes in the Ar⋯I2 (E, vE) levels preferentially dissociate into I2 in the D and β ion-pair states with no change in I2 vibrational excitation. The energetics of the levels prepared suggest that there is a non-adiabatic coupling of the initially prepared levels with the continuum of states lying above the Ar + I2 (D, vD = vE) and Ar + I2 (β, vβ = vE) dissociation limits. The angular anisotropies of the I2 product signals collected for many of the Ar⋯I2 (E, vE) levels have maxima parallel to the laser polarization axis. This contradicts expectations for the prompt dissociation of complexes with T-shaped geometries, which would result in images with maxima perpendicular to the polarization axis. These anisotropies suggest that there is a perturbation of the transition moment in these clusters or there are additional intermolecular interactions, likely those sampled while traversing above the attractive wells of the lower-energy potentials during dissociation. I2 (D′, vD′) products are also identified when preparing several of the low-lying levels localized in the T-shaped well of the Ar + I2 (E, vE = 0–2) potentials, and they are formed in multiple νD′ vibrational levels spanning energy ranges up to 500 cm−1.
Address terms in social media requests
Authors: Ren Wei , Fukushima Saeko 
Published: September 2023

Abstract
Although address terms have been examined in Chinese and
Japanese, few studies have compared the use of address terms between the two
languages. This study investigates address terms in Chinese and Japanese in
social media communication, focusing on requests between university
students. Two sets of data were collected, one from social media and the
other from focus groups. The findings revealed both similarities and
differences in address terms in the two languages. Neither Chinese nor
Japanese participants use address terms frequently in social media requests
between peers. When they employ address terms between peers on social media,
both groups prefer using first names and nicknames. However, Chinese
participants tend to use kinship terms frequently, which are not used by
Japanese participants. It is argued that factors such as social distance,
pragmatic constraints, language play, preference for positive politeness,
globalisation, and new technologies all contribute to the findings here.
Continuous monitoring of cardiovascular function with a smart stent incorporating a flexible and stretchable wireless pressure sensor
Authors: Oyunbaatar Nomin-Erdene , Shanmugasundaram Arunkumar , Kwon Kyeongha , Lee Dong-Weon 
Published: September 2023

Abstract
The development of smart stents, capable of monitoring cardiovascular diseases and communicating vascular abnormalities to medical doctors, has garnered significant attention in the field of biomedical engineering. Various ex-situ fabrication strategies have been proposed to concurrently manufacture the smart stent and pressure sensor, thereby reducing the risk of sensor detachment caused by blood flow. However, the practical utility of these devices is still limited due to the rigidity of the wireless pressure sensor. In this study, we propose a flexible and stretchable smart self-reporting stent that incorporates a wireless pressure sensor. The fabrication process has been optimized to create a serpentine-shaped wireless pressure sensor that matches the shape and flexibility of the polymer stent struts. We thoroughly investigated the structural integrity, resonance frequency, stretchability, flexibility, and radial force of the manufactured smart self-reporting stent under different conditions. The wireless pressure sensor demonstrated a sensitivity of 0.15 MHz mmHg−1, as determined through experimental analysis. To demonstrate the feasibility of the proposed smart stent, we implanted it into the arteries of a three-dimensional phantom system. The obtained results, combined with the flexible and stretchable nature of the proposed smart self-reporting stent, highlight its potential for effective monitoring of the heart’s functional dynamics and detection of in-stent restenosis.
A noise reduction method of rolling bearing based on empirical wavelet transform and adaptive time frequency peak filtering
Authors: Lu Jiantao , Jia Bin , Li Shunming , Gong Siqi 
Published: September 2023

Abstract
The vibration signal of rolling bearing with variable operating conditions contains complex interference components, which will cause low fault diagnosis accuracy, especially in strong noise case. To solve this problem, we proposed a noise reduction method of rolling bearing with variable operating based on empirical wavelet transform and adaptive time-frequency peak filtering (EWT-ATFPF). Firstly, empirical wavelet transform is used to obtain different frequency intrinsic mode functions (IMFs). Secondly, a modified adaptive window length formula for time-frequency peak filtering (TFPF) is constructed by combining the sampling ratio index and a fault sensitivity indicator that calculated by kurtosis and correlation coefficients of IMFs, which can better characterize the impact components. Thirdly, to balance noise reduction effect and the fidelity of IMFs, we proposed an improved TFPF method by adaptively adjusting its windows length. The adaptive method could be carried out using the proposed fault sensitivity indicator and window length formula, and the denoising IMFs could be obtained by ATFPF. Finally, the denoising vibration signal is reconstructed by using the denoising IMFs. The performance of fault diagnosis of the proposed method is verified by using simulated signal and bearing fault test data. The results show that the proposed EWT-ATFPF method could effectively achieve noise reduction under variable operating conditions.
Nonlinear auto regressive Elman neural network combined with unscented Kalman filter for data-driven dynamic data reconciliation in dynamic systems
Authors: Zhang Zhenhui , Hong Zhihui , Zhang Zhengjiang , Guo Fengyi , Zhao Sheng , Huang Shipei 
Published: September 2023

Abstract
Measurement data plays an important role in the control system, but the data collected by sensors often has measurement noise, which makes the states of the system cannot be accurately revealed. Unscented Kalman filter (UKF) is a highly accurate and robust filtering algorithm, but its limitation is the requirement of prior knowledge of the exact dynamic mathematical model, which is a critical issue to be addressed in practice. In this work, a data-driven dynamic data reconciliation scheme called nonlinear auto regressive Elman neural network (ENN) with exogenous inputs combined with UKF (NARX-ENN-UKF) is proposed, where nonlinear auto regressive ENN with exogenous inputs is used for dynamic data-driven modeling, and then UKF is applied for dynamic data reconciliation of the measurements based on the trained model. The scheme is applied to a DC/AC inverter experimental system and a self-developed sliding electrical contact experimental system to verify the effectiveness of NARX-ENN-UKF.
Noise assessment of CMOS active pixel sensors for the CYGNO Experiment
Authors: Almeida B D , Amaro F D , Antonietti R , Baracchini E , Benussi L , Bianco S , Borra F , Capoccia C , Caponero M , Cardoso D S , Cavoto G , Costa I A , D’Imperio G , Danè E , Dho G , Di Giambattista F , Di Marco E , Iacoangeli F , Kemp E , Lima Júnior H P , P Lopes G S , Maccarrone G , P Mano R D , Marcelo Gregorio R R , G Marques D J , Mazzitelli G , McLean A G , Meloni P , Messina A , Monteiro C M B , Nobrega R A , Pains I F , Paoletti E , Passamonti L , Petrucci F , Piacentini S , Piccolo D , Pierluigi D , Pinci D , Prajapati A , Renga F , d C Roque R J , Rosatelli F , Russo A , Saviano G , C Spooner N J , Tesauro R , Tomassini S , Torelli S , Tozzi D , F dos Santos J M 
Published: September 2023

Abstract
Active Pixel sensors play a crucial role in enabling successful low-light scientific experiments due to their inherent advantages and capabilities. Such devices not only offer high spatial resolution but also feature individual pixels with integrated amplifiers, allowing for direct signal amplification at the pixel level. This results in reduced readout noise and improved signal-to-noise ratio (SNR), which are particularly vital when dealing with limited photon counts in low-light environments. This holds particularly true for scientific CMOS (sCMOS) sensors, acknowledged as an advanced evolution of Active Pixel sensors. However, despite their advantages, such sensors can still exhibit limitations such as higher cost and presence of noise artifacts that should be closely investigated. In particular, CYGNO project fits in a global effort aimed at direct detection of Dark Matter particles. CYGNO collaboration intends to build a detector based on a Time Projection Chamber making use of Gas Electron Multipliers for the amplification of ionization electrons. The GEM multiplication process produces photons that can be readout by a high-resolution sCMOS sensor. Such detection system is being designed to have enough sensitivity to detect low-energy particles and to measure released energy with enough granularity so to reconstruct direction and energy profile along their trajectories. The image sensor has an important role in the detector performance, having a direct impact on the SNR of the experiment. This work proposes a study on the performance of three different sCMOS sensors with respect to their sensitivity to low-energy particles and their intrinsic noise, which are of the utmost importance for various scientific experiments.
The Near Infrared Imager and Slitless Spectrograph for the James Webb Space Telescope. I. Instrument Overview and In-flight Performance
Authors: Doyon René , Willott Chris J. , Hutchings John B. , Sivaramakrishnan Anand , Albert Loïc , Lafrenière David , Rowlands Neil , Begoña Vila M. , Martel André R. , LaMassa Stephanie , Aldridge David , Artigau Étienne , Cameron Peter , Chayer Pierre , Cook Neil J. , Cooper Rachel A. , Darveau-Bernier Antoine , Dupuis Jean , Earnshaw Colin , Espinoza Néstor , Filippazzo Joseph C. , Fullerton Alexander W. , Gaudreau Daniel , Gawlik Roman , Goudfrooij Paul , Haley Craig , Kammerer Jens , Kendall David , Lambros Scott D. , Ignat Luminita Ilinca , Maszkiewicz Michael , McColgan Ashley , Morishita Takahiro , Ouellette Nathalie N.-Q. , Pacifici Camilla , Philippi Natasha , Radica Michael , Ravindranath Swara , Rowe Jason , Roy Arpita , Roy Niladri , Saad Karl , Sohn Sangmo Tony , Talens Geert Jan , Touahri Driss , Thatte Deepashri , Taylor Joanna M. , Vandal Thomas , Volk Kevin , Wander Michel , Warner Gerald , Zheng Sheng-Hai , Zhou Julia , Abraham Roberto , Beaulieu Mathilde , Benneke Björn , Ferrarese Laura , Jayawardhana Ray , Johnstone Doug , Kaltenegger Lisa , Meyer Michael R. , Pipher Judy L. , Rameau Julien , Rieke Marcia , Salhi Salma , Sawicki Marcin 
Published: September 2023

Abstract
The Near-Infrared Imager and Slitless Spectrograph (NIRISS) is the science module of the Canadian-built Fine Guidance Sensor onboard the James Webb Space Telescope (JWST). NIRISS has four observing modes: (1) broadband imaging featuring seven of the eight NIRCam broadband filters, (2) wide-field slitless spectroscopy at a resolving power of ∼150 between 0.8 and 2.2 μm, (3) single-object cross-dispersed slitless spectroscopy (SOSS) enabling simultaneous wavelength coverage between 0.6 and 2.8 μm at R ∼ 700, a mode optimized for exoplanet spectroscopy of relatively bright (J < 6.3) stars and (4) aperture masking interferometry (AMI) between 2.8 and 4.8 μm enabling high-contrast (∼10−3 − 10−4) imaging at angular separations between 70 and 400 mas for relatively bright (M < 8) sources. This paper presents an overview of the NIRISS instrument, its design, its scientific capabilities, and a summary of in-flight performance. NIRISS shows significantly better response shortward of ∼2.5 μm resulting in 10%–40% sensitivity improvement for broadband and low-resolution spectroscopy compared to pre-flight predictions. Two time-series observations performed during instrument commissioning in the SOSS mode yield very stable spectro-photometry performance within ∼10% of the expected noise. The first space-based companion detection of the tight binary star AB Dor AC through AMI was demonstrated.
Stress intensity factors of partially compressed centrally cracked disk with frictional crack surfaces
Authors: Fayed A S , Hammouda Mohammad M I 
Published: September 2023

Abstract
This work analytically calculates mixed-mode I/II stress intensity factors for an inclined central frictional crack in a Brazilian disc partially compressed with a uniform pressure. Wide-range controlling parameters are invoked. The analyzed parameters include the pressure angle, relative crack length, crack inclination, and friction coefficient between the two crack surfaces. For partially compressed discs, there exists a critical pressure angle at which a crack with any angle will experience pure II loading. This critical pressure angle is not affected by friction and decreases as the crack length increases. A crack of any angle becomes inactive once the pressure angle exceeds another critical value of pressure angle. This value decreases as the friction coefficient or/and crack length increases. The handling of frictional surfaces of short cracks is simplified. The analysis defines the conditions to have (1) the crack opened and (2) the two crack surfaces sticking. A close agreement is achieved with relevant findings in previous relevant investigations. The present results do not exist in relevant literature and are valuable in solving fracture mechanics problems of significance in relation to crack path in cracked brittle materials.
Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby
Authors: Boast Alison , How Jeu Ann , Lau Charis , Sett Arun , Gilby Damien , Burke Andrew , McWhinney Brett , Wright Connor , Tramontana Adrian , Globan Maria , Denholm Justin , Graham Stephen M , Osowicki Joshua 
Published: September 2023

Abstract
We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including bedaquline and delamanid, drugs not previously described in the treatment of congenital tuberculosis (TB).