bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental pressure on child body image, BMI, body image dissatisfaction associated with eating disorders: A path analysis
Authors: Chen Jiaoyan , Liu Keke , Zhang Juan , Liu Songhui , Wang Yuanyuan , Cao Ruiyao , Peng Xingwang , Han Mei , Han Hui , Yao Rongying , Fu Lianguo 
Published: March 2023

Abstract
Children's eating behaviors, body shape and body image cognition may be more susceptible to the influence of their parents, but these influences may be weakened with age. There may be different association pathways between parental pressure on children’s body image (PPCBI), body mass index (BMI), body image dissatisfaction (BID) and eating disorders (EDs) among children and adolescents at different developmental stages. This study aims to analyze the association pathways between PPCBI, BMI, BID and EDs among children and adolescents at different developmental stages. The stratified cluster sampling method was used to select 486 students aged 8–15 years in two 9-year schools. Children’s body height, weight, testicular volume and breast development were measured. PPCBI, BID, and EDs were investigated using the Appearance-related Social Stress Questionnaire, Body Size Questionnaire (BID-14), and EDI-1 scale, respectively. The boys with testicular volume <4 ml had significantly higher EDs score than girls with breast development <Tanner II (P<0.05). There were significant association pathways of PPCBI→BMI→BID→EDs and PPCBI→BID→EDs in boys with testicular volume <4 ml (β=0.035, P<0.01; β=0.059, P<0.01), boys with testicular volume ≥4 ml (β=0.032, P<0.01; β=0.175, P<0.001), and girls with breast development ≥Tanner II (β=0.026, P<0.01; β=0.172, P<0.001). There was a positive association pathway of PPCBI→EDs in boys with testicular volume <4 ml (β=0.30, P<0.001) and PPCBI→BID→EDs in girls with breast development <Tanner II (β=0.176, P<0.01). Parental pressure on children’s body image may positively predict children's eating disorders through BMI and body image dissatisfaction in boys and girls after puberty initiation and directly predict eating disorders in boys before puberty initiation; however, it indirectly predicts eating disorders only through BID in girls before puberty initiation.
Quantifying spatial complexity of settlement plans through fractal analysis
Authors: Bruvoll Hallvard 
Published: March 2023

Abstract
In this paper I investigate the possibilities and limitations of fractal analysis methods applied to archaeological and synthetic settlement plans, with the goal of providing quantitative measures of spatial randomness or noise, as well as potential tools for automated culture-historical attribution of settlement plans and socio-economic intra-site differentiation. The archaeological sample is made from Linear Pottery settlements in south-west Slovakia and Trypillia settlements in the Southern Bugh-Dnipro interfluve in central Ukraine, all based upon high quality geomagnetic site plans. Synthetic plans are constructed as geometrically ideal versions of the archaeological ones, with varying degrees of added spatial noise. A significant correlation between fractal dimension and noise level is revealed for synthetic settlement plans, independently of size, density, house-size distribution and basic layout. However, several methodological challenges persist, and further systematic exploration on larger samples is needed before these results may be generalised. All analysis is performed in the R language and the script is made freely available in order to facilitate further development.
Analysis of histopathology and changes of major cytokines in the lesions caused by Mycoplasma ovipneumoniae infection
Authors: Li Jidong , Chen Can , Gao Le , Wang Lingling , Wang Wei , Zhang Jinhua , Gong Zhenxing , Wang Jiandong , Guo Yanan 
Published: March 2023

Abstract
Background
Mycoplasma ovipneumoniae (M. ovipneumoniae) is wide epidemic in the world, and is the main pathogen of sheep pneumonia, causing a series of clinical symptoms, such as depression, anorexia, hyperthermia, cough, dyspnea and tract secretions and so on. In recent years, the prevalence of M. ovipneumoniae pneumonia has become increasingly serious in sheep farms in Ningxia, China, causing significant losses.
Results
In this study, a total of 105 samples were collected from 13 large-scale farms in Ningxia for pathogen isolation, identification, pathological dissection and histopathological observation. The results showed that 13 strains of M. ovipneumoniae were isolated from the samples collected from 13 farms. The lesions caused by M. ovipneumoniae were mainly in trachea, bronchus and lung, including necrosis of tracheal mucosal epithelial cells, disintegration of some epithelial cells, edema of mucosal lamina propria, with inflammatory cell infiltration, cytoplasmic vacuolization of epithelial cells of bronchial mucosa, massive infiltration of inflammatory cells in the alveolar space of lung, necrosis and hyperplasia of alveolar epithelial cells. Immunohistochemical analysis showed that the proportion of M. ovipneumoniae positive area in lung was the largest, followed by that in bronchus and trachea. The mRNA expression of cytokines in target organs were detected by qPCR. The results showed that the cytokines of significantly up-regulated mRNA expression in trachea was IL-12. The cytokines of significantly up-regulated mRNA expression in the bronchus included IL-10 and IL-12. The cytokines of significantly up-regulated mRNA expression in the lung included IL-1β and NF-κB.
Conclusions
Molecular identification of pathogens, immunohistochemical analysis and detection of inflammatory cytokines of lesion tissues play important roles in the diagnosis of M. ovipneumoniae infection. This study lays a foundation for the diagnosis, prevention, control and pathological damage mechanism of M. ovipneumoniae pneumonia.
‘Which severe COVID-19 patients could benefit from High dose dexamethasone? A Bayesian reanalysis of a randomized clinical trial
Authors: Sylvie Chevret , Lila Bouadma , Claire Dupuis , Charles Burdet , timsit jean-francois 
Published: March 2023

Abstract
Background: The respective benefits of high and low doses of dexamethasone (DXM) in patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and acute respiratory failure (ARF) are controversial, with two large triple-blind RCTs reaching opposite conclusions. In the COVIDICUS trial, we argued against any additional benefit of high-dose dexamethasone (DXM20). We aimed to explore whether some specific patient phenotypes could benefit from DXM20 compared to the standard of care dose of DXM (DXMSoC).
Methods: We performed a post hoc exploratory Bayesian analysis of 473 patients who received either DXM6 or DXM20 in the COVIDICUS trial. The primary outcome was the 60-day mortality rate of DXM20 over DXMSoC, with the treatment effect measured on the posterior mean of relative risk (RR) estimated using a beta-binomial model with 95% credibility intervals (95% CrI). Bayesian measures of interaction quantified the probability of interaction (Pr Interact) that the RR of 60-day death differed across the subsets by 20%.
Results: Overall, the posterior mean RR of Day 60 mortality was 1.06 with a 95% credible confidence interval (0.77 to 1.44) and a posterior probability of benefit and harm of 27.0% and 50.5%, respectively. There was some evidence of treatment by subset interaction according to age, with the benefit increasing in patients aged below 70 years (RR=0.74, 95% CrI 0.41-1.22) compared to those aged above 70 (RR=1.12, 95% CrI 0.77 to 1.60) (Pr Interact, 77%), when the time since symptoms onset was lower than 7 days (RR=0.66, 95% CrI 0. 36 to 1.09) compared to 7 days or more (RR=1.15, 95% CrI 0.76 to 1.67) (Pr Interact, 90%) and in patients receiving remdesivir (RR=0.62, 95% CrI 0.29 to 1.14) compared to those who did not (RR=1.12, 95% CrI 0.78 to 1.58) (Pr Interact, 88%).
Conclusions: In this exploratory post hoc Bayesian analysis, compared with standard-of-care DXM, high-dose DXM may benefit patients aged less than 70 years with severe ARF that occurred less than 7 days after symptoms onset. The use of remdesivir may also favour the benefit of DXM20. Further analysis is needed to confirm these findings.
Trial registration: NCT04344730, date of registration April 14, 2020 (https://clinicaltrials.gov/ct2/show/NCT04344730?term=NCT04344730&draw=2&rank=1); EudraCT: 2020-001457-43 (https://www.clinicaltrialsregister.eu/ctr-search/search?query=2020-001457-43).
Violence against health care workers in a crisis context: A Mixed Cross-Sectional Study in Eastern Democratic Republic of Congo
Authors: Makali Samuel Lwamushi , Lembebu Jean Corneille , Boroto Raïssa , Zalinga Christian Chiribagula , Bugugu Daniella , Lurhangire Emmanuel , Rosine Bigirinama , Chimanuka Christine , Mwene-Batu Pacifique , Molima Christian , Mendoza Jessica Ramirez , Ferrari Giovanfrancesco , Merten Sonja , Bisimwa Ghislain 
Published: March 2023

Abstract
Background

Health personnel in conflict zones face high levels of violence while also playing a crucial role in assisting the population in distress. For more than two decades, the eastern provinces of the Democratic Republic of the Congo (DRC), have been wracked by conflict. This study aims to describe the state of violence against Health Care Workers (HCWs) and the potential prevention mechanisms in eastern DRC.

Methods

In North and South Kivu, between February 5 and 21, 2021, we conducted a mixed cross-sectional convergent study in health facilities (health centers and hospitals). An anonymized self-administered questionnaire was sent to HCWs about their experience of violence in the 12 months prior to the study. In-depth individual interviews with HCWs, present on the day of the investigation, were also done to explore their experience of violence. A descriptive analysis of the quantitative data and a thematic analysis of the qualitative data was carried out.

Results

Of a total of 590 participants, 276 (45.9%) reported having experienced violence in the 12 months before the study. In North Kivu, aggressors were more frequently the patients (43.7% vs 26.5%) and armed group members (14.3% vs 7.9%) than in South Kivu. Most respondents (93.5%) reported verbal aggression (insults, intimidation, death threats). Other forms of physical aggression including with bare hands (11.2%), firearm (1.81%), and stabbing (4.7%). Only nearly one-tenth of the attacks were officially reported, and among those reported a higher proportion of sanctions was observed in South Kivu (8.5%) than in North Kivu (2.4%). The mechanisms proposed to prevent violence against HCWs were community initiatives and actions to strength the health system.

Conclusions

In Eastern DRC, HCWs face multiple and severe forms of aggression from a variety of individuals. The effects of such levels violence on HCWs and the communities they served could be devastating on the already pressured health system. Policy framework that defines the roles and responsibilities for the protection of HCWs and for the development and implementation of preparedness measures such as training on management of violence are possible solutions to this problem.
Socioeconomic inequalities in obesity during 2006-2017 in Spain: An outcome-wide epidemiology approach
Authors: Sánchez-Recio Raquel , Magallares Alejandro 
Published: March 2023

Abstract
Purpose: In Western developed countries, people living in less affluent circumstances are more likely to have obesity, while individuals in the upper socioeconomic strata are in a better position to protect themselves against this medical condition. The current study used the Spanish National Health Survey during 2006-2017 to investigate trends between men and women in the socioeconomic patterns of obesity in Spain from an outcome-wide epidemiology approach.
Methods: The data came from the 2006, 2011, and 2017 Spanish National Health Surveys. The Spanish National Health Surveys are nationally representative surveys with a stratified multistage design. Sample sizes were 29,478 in 2006, 20,884 in 2011, and 22,903 in 2017, with a total sample size of 73,265 individuals.
Results: A statistically significant increase of obesity (men 15.39% vs. 18.11%, women 13.38% vs. 16.11%, p <.001) was observed in the three years analyzed (2006, 2011, and 2017). The Relative Index of Inequality (RII) and the Slope Index of Inequality (SII) showed that obesity was mainly concentrated in individuals from lower social strata. Both indices were higher in women than in men in the three years analyzed and these inequalities increased significantly during the studied period (RII p for trend: .009, SII p for trend <.001).
Conclusion: The current research shows the presence of socioeconomic inequalities in obesity in Spain during the years between 2006 and 2017. Obesity was mainly concentrated in disadvantaged social classes.
Level of evidence: Level V, descriptive cross-sectional survey
Machine learning approach for screening key genes of atherosclerosis and perform pan-cancer analysis
Authors: Zhan Zhenrun , Bi Xiaodan , Yang Jinpeng , Tang Xu , Zhao Tingting 
Published: March 2023

Abstract
Atherosclerosis is an immunoinflammatory disease caused by lipids which is an important factor in causing coronary heart disease and stroke. Medical researchers around the world are working on more effective ways to diagnose and treat it. This article will introduce a method of machine learning algorithm to screen biomarkers and perform pan-cancer analysis for reference. First, we downloaded the GEO dataset containing information on atherosclerotic patients for differential gene screening. At the same time, we also used TCGA and GTEx databases for pan-carcinogenic analysis of differential genes. Then, we performed WGCNA analysis. The selected module genes were crossed with the differential genes to obtain 122 key genes. Four machine learning algorithms, XGBoost, RandomForest, SVM-REF and GLM, were used to calculate the critical genes and get the junction of the results to obtain 4 hub genes (SLAMF8, TLR2, VAMP8 and VSIG4). Next, we build a diagnostic model and assess the capabilities of this model.At the same time, the ROC curves of the four genes also suggest that their role in the development of atherosclerosis is critical. Next, we performed gene correlation analysis, immune infiltration analysis and RT-PCR verification of the four core genes, and finally screened out TLR2 for pan-carcinoma. Through analysis, we can find that the expression of TLR2 in patients with a variety of tumors is different from that of normal people, and it is strongly associated with the proportion of prognosis of patients with diverse cancers. The results suggest that TLR2 may be a target for intervention in the development of diseases such as atherosclerosis and tumors.
Exploring the Variations in Death Anxiety among Oncology Nurses in China: A Latent Class Analysis
Authors: Chen Xian , Su Mengyu , Arber Anne , Qiao Chengping , Wu Jinfeng , Sun Cuihua , Wang Dan , Zhou Hui , Zhu Zhu 
Published: March 2023

Abstract
Background
Various factors have been found to be associated with high levels of death anxiety experienced by oncology nurses. However, the identification of internal heterogeneity of their death anxiety has not been fully explored.
Methods
A cross-sectional survey conducted in Jiangsu Province, China, to assess the level of death anxiety, palliative care knowledge, and attitude of registered oncology nurses towards palliative care. The collected data were analyzed using Latent Class Analysis (LCA), logistic regression, and Pearson correlation.
Results
A two-potential-category model was selected based on the fit index. The results showed that 79.17% of oncology nurses belonged to the high pressure and pain group and 20.83% belonged to the low death anxiety group. The high pressure and pain group had significantly higher scores in the dimensions of emotion, stress and pain, time awareness, and cognition compared to the low death anxiety group. Factors influencing the high pressure and pain group included shorter working years, non-national or provincial oncology nursing specialists, non-national palliative care specialists, never discussing the topic of death with patients or family members, no palliative care related training, and PCQN and FATCOD scores.
Conclusions
Our study suggests that oncology nurses' death anxiety can be divided into two categories: low death anxiety and high stress pain, and certain factors, such as being female, having a short work experience, and lacking palliative care-related training, increase the likelihood of death anxiety.
Lithium magnesium alloys: a framework for investigating lithium alloy anodes for solid state batteries
Authors: Aspinall Jack , Sada Krishnakanth , Guo Hua , Narayanan Sudarshan , Chart Yvonne , Jagger Ben , Milan Emily , Armstrong David , Pasta Mauro 
Published: March 2023

Abstract

Lithium alloys have the potential to overcome anode-side challenges in solid state batteries. In this work we synthesize and characterize lithium-rich magnesium alloys, quantifying the changes in mechanical properties, transport, and surface chemistry that impact electrochemical performance. Increases in hardness, stiffness,adhesion, and creep are quantified by nanoindentation as a function of magnesium content. A decrease in diffusivity is quantified with chronopotentiometry and6Li PFG-NMR, and an increase in interfacial impedance due to the presence of magnesium is identified with electrochemical impedance spectroscopy which is correlated with XPS data. Throughout, changes in properties are linked to electrochemical performance. This work provides a framework to investigate other lithium alloy systems.
Evaluation of material flows in the Mé River watershed (Ivory Coast)
Authors: Koffi Ehouman Serge , Kamagaté Anzoumanan , Koffi Koffi Jean Thierry , Dao Amidou , Noufé Dabissi Djibril , Kamagaté Bamory , Goné Lanciné Droh , Guilliod Maurice , Séguis Luc , Perrin Jean Louis 
Published: March 2023

Abstract
Soil erosion by precipitation, rainfall and runoff is a widespread phenomenon in different countries of the world. It becomes disastrous in particular on the slopes because of the torrentiality of the flow, of the strong vulnerability of the grounds (soft rocks, fragile grounds, steep slopes). The present study has for objective: The analysis of the data of concentrations of sediments in suspension are measured at the station of the rivers highlights relations, linking the concentration (or the solid flow) of the sediments in suspension to the liquid flow and to quantify the seasonal, monthly and interannual and intra annual variation of the surface degradation. Annual tonnage estimates of solids loads to the Mé were derived from the power law for all seasons. From this deduction, the annual quantities of sediment transported by the Mé from 2015/2017 is 7.06.106 t/year, or a specific degradation of 1.79.103 t/km²/year. On the other hand, in 2017, the value of this solid input is 3.06.106 t/year. However, the annual solid input is estimated at 7063.03.103 t/year with a specific degradation of 1784.47 t/km²/year at the Mé from 2015 to 2017.
Spatiotemporal dynamics of the aridity index in Xinjiang over the past 60 years
Authors: Wu Xiulan , Zhang Cunjie , Dong Siyan , Hu Jiahui , Tong Xinyi , Zheng Xiannian 
Published: March 2023

Abstract
Precipitation change and dry‒wet trend are the most critical natural factors that determine the social development and civilization process in Xinjiang. The Aridity Index (AI), calculated from 99 homogeneous meteorological stations from 1961 to 2020,was used to analyze the variation of dry‒wet climate change in Xinjiang in the past 60 years . The results show that the annual AI in Xinjiang has shown a significant decreasing trend over the past 60 years; that is, the climate in Xinjiang, especially southern Xinjiang, has become wetter. The interdecadal variations from the 1960s-2010s show that the total station ratio of arid and extremely arid areas in Xinjiang showed a decadal decreasing trend, while the subarid areas and humid and semihumid areas showed increasing trends, especially since the beginning of the 21st century. The interdecadal spatial evolution characteristics show that the dry‒wet climate in Xinjiang reversed in the 1990s. An abrupt change in the annual aridity index occurred in 1986, after which the study region was basically in a continuous wetting process. The first empirical orthogonal function (EOF) decomposition mode is consistent in Xinjiang; that is, the climate in Xinjiang is generally dry or wet, and the intensity of this change varies among different regions. The second mode reflects the opposite spatial distribution characteristics of the dry‒wet climate in southern and northern Xinjiang with the Tianshan Mountains. Dry‒wet climate changes in Xinjiang mainly exhibit 2.5-year and 6-year oscillation periods, between which the 6-year period is more significant.
Upregulation of SOX12 is correlated with poor prognosis and immune infiltrates in skin cutaneous melanoma
Authors: Hao Miao , Liu Tie , He Simin , Du Jianshi , Cong Xianling 
Published: March 2023

Abstract
Background
Skin cutaneous melanoma (SKCM) is the deadliest form skin cancer worldwide. Tumor immunotherapy has become a new strategy for tumor treatment, particularly for highly metastatic malignant tumors. However, there are no effective biomarkers for immunotherapy in patients with SKCM. As a crucial transcription factor, sex-determining region Y-box 12 (SOX12) plays a critical role in tumorigenesis and malignant transformation of many malignant tumors. Because the function and mechanism of SOX12 in SKCM remain unknown, further investigation is necessary. In this study, we aimed to assess the clinical prognostic value of SOX12 in patients with SKCM.
Methods
The expression of SOX12 was assessed using RNA-seq data obtained from The Cancer Genome Atlas (TCGA) database. Subsequently, we performed Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Gene Set enrichment (GSEA), and Gene set variation analyse (GSVA) to further explore the functions of SOX12. Moreover, Cox multivariate, Kaplan-Meier, and receiver operating characteristic (ROC) curve analyses were used to determine the predictive value of SOX12 for SKCM. Finally, RT-qPCR, hematoxylin-eosin (HE) staining, and immunohistochemical (IHC) analyses were used to verify the expression and clinical value of SOX12 in melanoma cell lines and tissues.
Results
SOX12 was highly expressed in SKCM tissue compared to that in normal tissue. Our results confirm that SOX12 expression is a potentially valuable indicator for SKCM diagnosis and prognosis. GSEA confirmed that SOX12 expression was closely associated with immune and epigenetic modifications. In addition, SOX12 may be involved in the metastasis and progression of SKCM through immunomodulation and methylation modifications. Overexpression of SOX12 in SKCM cell lines and tissues was also confirmed using RT-qPCR, HE staining, and IHC analyses.
Conclusions
Our research suggests that SOX12 can be used as a diagnostic and prognostic biomarker and for SKCM treatment. Our results also contribute to the comprehensive understanding of SOX12 from a bioinformatics perspective and highlight its significance in SKCM diagnosis and treatment.