bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Liquid Multicarbon Production from Overall CO2 Photoreduction by Creating a Superhydrophobic Gas Storage Space
Authors: Huo Hailing , Du Zhengwei , He Hua , Guan Xin , Huang Chengxi , Wu Fang , Du Yongpin , Xing Hongbin , Ma Jingjing , Li Ang , Kan Erjun 
Published: January 2023

AbstractIt is exceedingly desired yet challenging to steer the photocatalytic overall CO2reduction reaction (CRR) toward high-value liquid products, especially multicarbon products like ethanol. Numerous attempts have been reported such as developing new materials, cocatalyst engineering, etc. Here, we find that by just curling the superhydrophobic Cu2O to create an enclosed Cu2O hollow structure, the selectivity of ethanol (59.59%) is impressively elevated by ~ 9 times higher than that without the enclosed hollow structure. Further investigations indicate that the superhydrophobic hollow structure can efficiently repel water out and thus create an enclosed gas storage space, enabling the high concentration of CO2molecules. With such a strategy, an impressive ethanol generation rate of 996.18 µmol g− 1h− 1is achieved. The mechanism is also investigated based on theoretical calculations and corresponding characterizations. This strategy provides a geometry-modulated method with high compatibility, which is promising to develop more efficient photocatalysts for multicarbon production combined with other traditional methods.
Mechanism of vorticity amplification by elastic waves in a viscoelastic channel flow
Authors: Li Yuke , Steinberg Victor 
Published: January 2023

Abstract
Inertia-less viscoelastic pipe and channel flows
exhibit a non-normal mode elastic instability independent of perturbation strength and despite
their linear stability. The non-modal instability
is identified mostly by a direct transition from
laminar to chaotic flows. At higher velocities,
transitions to elastic turbulence and further drag
reduction occurs accompanied by elastic waves in
three regimes. Here we demonstrate experimentally that the elastic waves play a key role in
amplifying wall-normal vorticity fluctuations by
resonant pumping of energy, withdrawn from the
mean flow, into wall-normal fluctuating vortices.
Indeed, the flow resistance and rotational part of
the wall-normal vorticity fluctuations depend linearly on the intensity of elastic waves in three
regimes. The higher (lower) the elastic wave intensity, the larger (smaller) the flow resistance
and rotational vorticity fluctuations. The suggested physical mechanism of the resonant vortex
amplification by the elastic waves above the instability onset in three flow regimes recalls the Landau damping in magnetized relativistic plasma. It
is universal not only for various viscoelastic parallel shear flows but also generally for flows with
both transverse waves and wall-normal vortices,
such as the Alfven waves interacting with vortices
in turbulent magnetized plasma.
Overnight Fasting only or Polyethylene Glycol Preparation for Capsule Endoscopy for detection of the Source of Overt Suspected Small Bowel Bleeding： a retrospective study
Authors: Dai Jing-Ping , Ding Zhuo-Yu , Pan Chao-Min , Yang Li , Wang Xin-Ke 
Published: January 2023

Abstract
Background
Small bowel capsule endoscopy (SBCE) is recommended as the first choice of small bowel evaluation for suspected small bowel bleeding (SBB). However, there is no consensus on the cleansing criteria prior to SBCE.
Aim
We aimed to assess the effectiveness of the purgative regimen and the overnight fasting only method before undergoing SBCE.
Methods
This was a retrospective study of 102 patients who underwent SBCE to detect the source of active or sub-acute overt suspected SBB. 63 Patients in Group A consumed 2 L of PEG (Polyethylene glycol) before SBCE after an overnight fast; whereas 39 patients in Group B performed 12 hours overnight fast before the procedure. The primary endpoint was lesion findings and diagnostic yield, and the secondary endpoints were clinical outcomes, capsule endoscopy completion rate (CECR), transit time and the small bowel visualization quality (VQ).
RESULTS
The positive finding was ascertained in 38 patients in Group A (60.3%), and 18 in Group B (46.2%; P = 0.162). There was no significant difference in diagnosis yield in 2 groups (47.6% vs. 51.3%; P = 0.719), the same as the sensitivity (53.6% vs. 58.8%; P = 0.627) and specificity (71.4% vs. 100%; P = 0.470). The percentage of excellent or good small bowel VQ in Group A was significantly more than in Group B (57.2% vs. 38.5%, P = 0.0012). The median small-bowel transit time for Group A was statistically significant shorter than Group B (400 min vs. 519 min; P = 0.01). No evidence of differences was detected between the two groups in further treatment methods and prognosis(P = 0.209).
CONCLUSION
2L PEG-based bowel preparation before SBCE does not result in improvement of diagnostic yield or clinical outcomes, although the small bowel visualization quality is enhanced.
The rationality of continuous improvement of stress ulcer preventive medication by orthopedic clinical pharmacists in tertiary teaching hospitals
Authors: Xu Yichun , Yang Huan , Shen Jianghua , Su Su , Xing Xiaoxuan , Zhang Lan , Chu Yanqi 
Published: January 2023

Abstract
Objective: We aim to evaluate the efficacy of clinical intervention by clinical pharmacists in improving prophylactic medication for stress ulcer, and explore the application of Plan-Do-Check-Act (PDCA) in promoting rational stress ulcer prophylaxis (SUP).
Methods: We conducted a retrospective study of 1702 patients in the Department of Orthopedics at a tertiary teaching hospital in China from January 2021 to October 2022. 778 and 924 patients were included in the pre-PDCA and post-PDCA groups, respectively. Clinical pharmacists established the criteria for SUP and conducted interventions, including doctor's prescription review, opinion feedback, clinical education and result analysis. We analyzed the improvement of irrational drug use and medical cost in stress ulcer prophylaxis before and after the establishment of PDCA cycle.
Results: Clinical pharmacist-led continuous intervention and PDCA cycle significantly reduced the incidence of irrational SUP (79.31% vs. 23.41%), including medication duration, indications, usage and drug selection. The average duration of use of acid-suppressive drugs in each patient (days 3.90±2.29 vs. 2.68±1.97) the average SUP cost (CNY 166.58±116.25 vs. 126.48±104.16) and inappropriate SUP cost (CNY 70.40±84.47 vs. 25.53±68.66) were significantly decreased. The target compliance rate was 109.41%.
Conclusions: Clinical pharmacists can effectively improve irrational SUP through PDCA cycle to optimize drug use, so as to obtain better clinical and economic outcomes.
Intracellular Spatial Transcriptomic Analysis Toolkit (InSTAnT)
Authors: Kumar Anurendra , Schrader Alex , Boroojeny Ali , Asadian Marisa , Lee Juyeon , Song You , Zhao Sihai , Han Hee-Sun , Sinha Saurabh 
Published: January 2023

Abstract

Imaging-based spatial transcriptomics technologies such as MERFISH offer snapshots of cellular processes in unprecedented detail, but new analytic tools are needed to realize their full potential. We present InSTAnT, a computational toolkit for extracting molecular relationships from spatial transcriptomics data at the intra-cellular resolution. InSTAnT detects gene pairs and modules with interesting patterns of mutual co-localization within and across cells, using specialized statistical tests and graph mining. We showcase the toolkit on datasets profiling a human cancer cell line and hypothalamic preoptic region of mouse brain. We performed rigorous statistical assessment of discovered co-localization patterns, found supporting evidence from databases and RNA interactions, and identified subcellular domains associated with RNA-colocalization. We identified several novel cell type-specific gene co-localizations in the brain. Intra-cellular spatial patterns discovered by InSTAnT mirror diverse molecular relationships, including RNA interactions and shared sub-cellular localization or function, providing a rich compendium of testable hypotheses regarding molecular functions.
The Effects of a Journey of the Brave Counseling Program on Anxiety, Well-Being, and Life Adjustment in Taiwanese Children
Authors: Tien Hsiu-Lan Shelley , Su Yi-Ning , Zhang Aizi , Kaichi Isana , Koshiba Takako , Okawa Sho , Urao Yuko , Shimizu Eiji 
Published: January 2023

Abstract
The purposes of the current study are two-fold. Study 1 aimed to examine the psychometric properties of the Spence Children’s Anxiety Scale (SCAS) in a Taiwanese sample. Study 2 aimed to explore the immediate and follow-up effects of Journey of the Brave Counseling Program (JBCP) on children’s’ anxiety, well-being, and life adjustment. A review and suggestions were provided for future research and practitioners in educational and counseling fields as reference.
In Study 1, the pilot study included 150 to 200 children between ages 11 and 12 in Taoyuan City. In Study 2, we conducted a pretest-posttest nonequivalent groups quasi-experimental design. The participants in this stage were 16 children in an elementary school in Taoyuan City, between ages 11 and 12. After obtaining consent forms from the participants’ guardians, we randomly assigned these participants to an experimental group (N = 8) and a control group (N = 8). The experimental group received a 40-minute JBCP session weekly for ten weeks. The control group received a 40-minute career exploration small group counseling weekly for ten weeks. We administered the SCAS, Psychological Well-Being Scale, and School Life Adjustment Scale in the pretest, posttest, and follow-up test to measure change of anxiety, well-being, and life adjustment of the participants. In addition, the current study implemented some qualitative data, such as group progress notes, group member feedback questionnaires, and semi-structured interviews with participants’ homeroom teachers as supplementary data to clarify the effects of the JBCP.
In Study 1, we found that the SCAS had a good validity and reliability for Taiwanese children. The results of Study 2 indicated that the JBCP had immediate and follow-up effects on the separation anxiety in the experimental group. With the pretest impact eliminated, the immediate and follow-up effects on overall anxiety in the experimental group were better than those on the control group. However, even though the immediate and follow-up effects of the JBCP on the experimental group were better than the control group but were not significant. Besides, the group member feedback questionnaires and participants’ homeroom teachers all indicated that the experimental group participants had positive attitude toward the JBCP, and they also positively improved their emotions and interpersonal relationships with others.
Please Show Restraint: An Excessive Focus on Catastrophic Events Can Lead to Greater Psychological Trauma
Authors: Huang Xuefang , Zhao Qi , Lan Zhensong , Liu Huaqiang , Deng Fafang 
Published: January 2023

Abstract
This study explored the relationship between attention, negative emotions, empathy, mindfulness, and psychological trauma in catastrophic events to reduce the public’s psychological trauma. A total of 526 adults in Guangxi Province, China, were investigated using a self-rating scale for post-traumatic stress disorder, a self-rating emotion scale, a self-rating empathy scale, a five-factor self-rating mindfulness scale, and a catastrophic incident concern questionnaire. The results show that: (1) women are vulnerable to psychological trauma in catastrophic events (F [464]=0.681, p<0.05); (2) emotion has a significant mediating effect between attention and psychological trauma; (3) empathy has a significant mediating effect between attention and psychological trauma; and (4) mindfulness is conducive to buffering an individual’s negative emotions and also regulates the degree of psychological trauma in the public’s attention to catastrophic events. Therefore, people should be rational and restrained in the face of catastrophic events.
Impact of COVID-19 prevention and control on tuberculosis and scarlet fever in China’s Guizhou
Authors: Zhou Jian , Chen Hui-Juan , Lu Ting-Jia , Chen Pu , Zhuang Yan , Li Jin-Lan 
Published: January 2023

Abstract
China has implemented a series of long-term measures for the public in order to control spread of COVID-19,whether these measures will affect other chronic and acute respiratory infectious diseases and what kind of impact are unclear. Tuberculosis (TB) and scarlet fever (SF) as the representative of chronic and acute respiratory infectious diseases respectively,and China’s Guizhou was an area with high prevalence of TB and SF ,with about 40,000 TB and hundreds of SF cases were reported every year.To assess impact of COVID-19 prevention and control on TB and SF in China’s Guizhou, exponential smoothing method was used to establish a prediction model to analyze the impact of COVID-19 on the number of TB and SF cases in Guizhou,and spatial aggregation analysis was used to describe the spatial changes of TB and SF before and after the outbreak of COVID-19.The parameters of TB and SF prediction models are R²=0.856,
BIC=10.972;R²=0.714,BIC=5.325, respectively.TB and SF cases declined rapidly at the beginning of COVID-19 prevention and control,but SF cases number in decline for about 3-6 months,TB cases number remained in decline for 7 months after implementation for 11 months. Spatial aggregation of TB and SF did not change much before and after the COVID-19 outbreak but decreased significantly.Our fndings indicated that China's COVID-19 prevention and control measures also reduced TB and SF prevalence in Guizhou, these measures may lead to a long-term beneficial impact on TB, but a short-term on SF. Area with high TB incidence may benefit from COVID-19 experiences in the future.
Cytosine base editors (CBEs) for inducing targeted DNA base editing in Nicotiana benthamiana
Authors: luo juan , Abid Muhammad , Tu Jing , Cai Xinxia , Zhang Yi , Gao Puxin , Wang Zupeng , Huang Hongwen 
Published: January 2023

Abstract
Background: The base editors can introduce point mutations accurately without causing double-stranded DNA breaks or requiring donor DNA templates. Previously, cytosine base editors (CBEs) containing different deaminases are reported for precise and accurate base editing in plants. However, the knowledge of CBEs in polyploid plants is inadequate and needs further exploration.
Results: In the present study, we constructed three polycistronic tRNA-gRNA expression cassettes CBEs containing A3A, A3A (Y130F), and R33A to compare their base editing efficiency in allotetraploid N. benthamiana (n = 4x). We used 14 target sites to compare their editing efficiency using transient transformation in tobacco plants. The sanger sequencing and deep sequencing results showed that A3A-CBE was the most efficient base editor. In addition, the results showed that A3A-CBE provided most comprehensive editing window (C1 ~ C17 could be edited) and had a better editing efficiency under the base background of TC. The target sites (T2 and T6) analysis in transformed N. benthamiana showed that only A3A-CBE can have C-to-T editing events and the editing efficiency of T2 was higher than T6. Additionally, no off-target events were found in transformed N. benthamiana.
Conclusions: All in all, we conclude that A3A-CBE is the most suitable vector for specific C to T conversion in N. benthamiana. Current findings will provide valuable insights into selecting an appropriate base editor for breeding polyploid plants.
Economic Evaluation of Sarcopenia Management Interventions; a Lifetime Cost-Utility Analysis in Iran
Authors: Darvishi Ali , Shafiee Gita , Balajam Narges Zargar , Hemami Mohsen Rezaei , Ostovar Navid , Heshmat Ramin 
Published: January 2023

Abstract
Objectives
Identifying the optimal management intervention of sarcopenia is a concern of health systems. We aimed to analyze the cost-effectiveness of sarcopenia management strategies in Iran.
Methods
We constructed a lifetime Markov model based on natural history. The compared strategies included exercise training, nutritional supplements, whole body vibration (WBV), and various exercise interventions and nutritional supplement combinations. A total of 7 strategies was evaluated along with the non-intervention strategy. Parameter values were extracted from primary data and the literature, and the costs and Quality-adjusted life years (QALYs) were calculated for each strategy. Deterministic and probabilistic sensitivity analysis, including the expected value of perfect information (EVPI), was also performed to determine the robustness of the model. Analyses were performed using the 2020 version of TreeAge Pro software.
Results
All seven strategies increased lifetime effectiveness (QALYs). The protein and Vitamin D3 (P + D) strategy had the highest effectiveness values among all strategies. After removing dominated strategy, the estimated ICER for the P + D compared to Vitamin D3 alone (D) strategy was calculated as $131,229. Considering the cost-effectiveness threshold ($25,249), base-case results indicated that the D strategy was the most cost-effective strategy in this evaluation. Sensitivity analysis of model parameters also showed the robustness of results. Also, EVPI was estimated at $273.
Conclusions
Study results, as the first economic evaluation of sarcopenia management interventions, showed that despite the higher effectiveness of D + P, the D strategy was the most cost-effective. Completing clinical evidence of various intervention options can help in more accurate results in the future.
The effects of new technology on productivity: technological improvement and reallocation efficiency in the Japanese steelmaking industry
Authors: Kobayashi Ryuki 
Published: January 2023

Abstract
This paper analyzes the effect of new technology for steel refining -- the basic oxygen furnace -- on productivity growth using the productivity decomposition method. I employ a technique that decomposes productivity growth into four factors: operational improvement, within- and between-technology reallocation, and entry-exit effects. I demonstrate that the following two factors are both substantially important: (i) the rapid operational progress of new technology and (ii) between-technology reallocation both among existing furnaces and through entries. I also find that although the overall allocation efficiency improved, the within-new-technology allocation efficiency declined. The results suggest that government policies encouraged the construction of new furnaces by lowering the cost of introducing new technology, and firms were able to enjoy the high productivity gains from the new technology itself and its rapid growth.
Patients with temporomandibular disorders and chronic pain of myofascial origin display reduced alpha power density and altered Small-world properties of brain networks
Authors: Ito Clara Hikari , Campbell Fernanda Queirós , Montoya Pedro , Araújo Lucas , Santana Jamille Evelyn Rodrigues Souza , Meneses Francisco , Sá Katia Nunes , Fonseca André , Benevides Silvia Damasceno , Zana Yossi , Lopes Tiago da Silva , Baptista Abrahão Fontes 
Published: January 2023

Abstract
Chronic pain is one of the most common symptoms of temporomandibular disorders (TMD). Although its pathophysiology is still a challenge, TMD has been associated with changes in central nervous system activity related to pain modulatory capacity. This study was conducted to examine the cortical activity of patients with temporomandibular disorders and chronic pain of myofascial origin using quantitative electroencephalography (qEEG). Individuals with TMD and chronic pain and healthy controls were evaluated using qEEG in four consecutive conditions, all with closed eyes: 1) initial resting condition; 2) non-painful motor imagery task of hand movement; 3) painful motor imagery task of clenching the teeth; 4) final resting condition. Participants with TMD and chronic pain overall presented decreased alpha power density during baseline at rest, and non-painful and painful motor imagery tasks when compared to healthy controls. Furthermore, functional brain connectivity was distinct between groups, with TMD and chronic pain showing lower small-world values for the delta (all conditions), theta (eyes closed, painful and non-painful motor imagery task), and alpha bands (painful motor imagery task), and an increase in the beta band (all conditions). These results suggest that TMD and related chronic pain is associated with maladaptive plasticity in the brain, which may correspond to a reduced ability to modify brain activity during different mental tasks, including painful and non-painful imagery. These changes can be detected by qEEG, a method which may be very important because of its characteristics of good temporal resolution and the possibility to be performed in naturalistic setups.
Probiotic Bacillus licheniformis MCC2514 and Bifidobacterium breve NCIM 5671 regulate GATA3 and Foxp3 expression in the elevated disease condition
Authors: HS Rohith , Pedda Muthukumar Serva , Halami Prakash Motiram 
Published: January 2023

Abstract
The TNBS-induced ulcerative colitis was evaluated using B. licheniformis and Bf. breve as immune modulator. The study aims to analyze the probiotic efficiency of ulcerative colitis induced by TNBS in Wistar rats. The tumor-like structure was found in colon of TNBS inflammation-induced rats. Nitric oxide production was inhibited by about 65.2% fed with combination of bacteria and C-reactive protein, decreased by 12% and 10.8% upon supplementing B. licheniformis and Bf. breve against the TNBS-treated rats, respectively. Liver damage was observed in the TNBS-treated rats, SGPT (75.4%) and SGOT (42.5%) were reduced by addition of probiotic bacteria. On TNBS treatment, transcriptional factor responsible for Th2 cell immune response (GATA3) was analyzed, and the elevation in gene expression (5.31 folds) was found. The FOXP-3 responsible for T-regulatory cells was expressed about 0.91 folds upon the treatment with combination of bacteria. The expression of antioxidant genes such as iNOS (1.11 folds), GPx (1.29), and PON1 (1.48) has been increased when compared with TNBS treated group. The cytokines specific to the Th2-driven immune response, such as IL-4, IL-5, and TNF-α, were reduced upon feeding the bacteria. It is observed that the B. licheniformis and Bf. breve used in the study has reduced the Th2-driven immune response.