bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurology care and the long-term outcomes of atrial fibrillation-related ischaemic stroke in China: median 3-year outcome from a high volume academic tertiary hospital
Authors: Wang Zidun , Wu Nan , Wu Fengming , Zhang Lian , Gao Xiaoyuan , Yang Yilan , Li Mingfang , Wan Qi , Chen Minglong 
Published: February 2023

ObjectivesThe initial medical contact of patients with atrial fibrillation (AF) and ischaemic stroke is often performed by neurologists. However, when stand care with oral anticoagulants (OACs) adherence and persistence was emphasised by cardiologists, data regarding the gap between current neurology care and standard care from Chinese tertiary hospitals is scarce and the long-term outcome is unknown. This study was to investigate the AF detection rate, the use of anticoagulation therapy and posthospital clinical outcomes associated with neurology care in patients with AF and ischaemic stroke in China.DesignA retrospective cohort study.SettingClinical data of all patients who had an ischaemic stroke discharged from the neurologic department of a high-volume academic hospital from 1 January 2013 to 31 December 2017 were analysed and patients were followed.ParticipantsPatients diagnosed with ischaemic stroke and AF were included.Main outcome measuresThe usage of anticoagulation at discharge, the posthospital restroke rate and all-cause mortality.ResultsAmong 5797 patients who had an ischaemic stroke, 373 (6.43%) patients were diagnosed with AF during hospitalisation. Among them, only 198 (53.66%) patients were on anticoagulation therapy at discharge. A total of 325 (88.08%) patients were accessible and received follow-up. After a median 3-year follow-up, 103 (31.69%) patients died due to all causes. Among them, 53 (16.31%) patients died from recurrent stroke. And 86 (26.46%) patients restroked. In multivariable analysis, patients without anticoagulation therapy, muscle strength<grade 3 at discharge, coronary artery disease and advanced age predicted the recurrent stroke.ConclusionsSecondary stroke prevention in AF patients associated with neurology care is challenging in China, as manifested by a lower AF detection rate, significant underuse of OACs, high mortality and recurrent stroke rate. Efforts to increasing the AF detection rate and reinforce education on neurologists should be made to improve neurology care and intensify posthospital management in such patients.
Demographic characteristics, long-term health conditions and healthcare experiences of 6333 trans and non-binary adults in England: nationally representative evidence from the 2021 GP Patient Survey
Authors: Saunders Catherine L , Berner Alison , Lund Jenny , Mason Amy M , Oakes-Monger Tash , Roberts Meg , Smith Jack , Duschinsky Robbie 
Published: February 2023

ObjectiveIn order to address the lack of data on the health and healthcare needs of trans and non-binary adults, NHS England includes questions asking about both gender and trans status in its surveys to support quality improvement programmes.We used self-reported data from the GP Patient Survey to answer the research question: what are the demographic characteristics, health conditions and healthcare experiences of trans and non-binary adults in England?Design/settingNationally representative, population-based cross-sectional survey in England with survey data collection from January to March 2021.Participants840 691 survey respondents including 6333 trans and non-binary adults.OutcomesWe calculated weighted descriptive statistics, and using logistic regression explored 15 long-term physical and mental health conditions, and 18 patient experience items, covering overall experience, access, communication and continuity.ResultsTrans and non-binary adults were younger, more likely to be from Asian, black, mixed or other ethnic groups and more likely to live in more deprived parts of the country. Age-specific patterns of long-term conditions were broadly similar among trans and non-binary adults compared with all other survey respondents, with some variation by condition. Overall, inequalities in long-term health conditions were largest for autism: OR (95% CI), 5.8 (5.0 to 6.6), dementia: 3.1 (2.5 to 3.9), learning disabilities: 2.8 (2.4 to 3.2) and mental health: 2.0 (1.9 to 2.2), with variation by age. In healthcare experience, disparities are much greater for interpersonal communication (OR for reporting a positive experience, range 0.4 to 0.7 across items) than access (OR range 0.8 to 1.2). Additionally, trans and non-binary adults report much higher preference for continuity 1.7 (1.6 to 1.8), with no evidence of any differences in being able to see or speak to a preferred general practitioner.ConclusionThis research adds up to date evidence about population demographics, health and healthcare needs to support healthcare improvement for trans and non-binary adults.
Musculoskeletal health state and physical function of intensive care unit survivors: protocol for a UK multicentre prospective cohort study (the MSK-ICU study)
Authors: Gustafson Owen , King Elizabeth , Schlussel Michael , Rowland Matthew , Dawes Helen , Williams Mark A 
Published: February 2023

IntroductionSurvivors of critical illness frequently experience long-term physical impairment, decreased health-related quality of life and low rates of return to employment. There has been limited investigation of the underlying problems affecting physical function post-intensive care unit (ICU) admission. Musculoskeletal (MSK) conditions may be complex in presentation, with ICU survivors potentially at greater risk of their development due to the rapid muscle mass loss seen in ICU. The MSK health state of ICU survivors and its impact on physical function remain largely unknown. The aim of the MSK-ICU study is to determine and characterise the MSK health state of ICU survivors 6 months following admission to ICU, in order to inform development of targeted rehabilitation interventions.Methods and analysisThe MSK-ICU study is a multicentre prospective longitudinal cohort study, evaluating the MSK health state of ICU survivors 6 months after admission to ICU. The study consists of a primary study and two substudies. The primary study will be a telephone follow-up of adults admitted to ICU for more than 48 hours, collecting data on MSK health state, quality of life, employment, anxiety and depression and symptoms of post-traumatic stress disorder. The planned sample size is 334 participants. Multivariable regression will be used to identify prognostic factors for a worse MSK health state, as measured by the MSK-Health Questionnaire. In substudy 1, participants who self-report any MSK problem will undergo a detailed, in-person MSK physical assessment of pain, peripheral joint range of movement and strength. In substudy 2, participants reporting a severe MSK problem will undergo a detailed physical assessment of mobility, function and muscle architecture.Ethics and disseminationEthical approval has been obtained through the North of Scotland Research Ethics Committee 2 (21/NS/0143). We aim to disseminate the findings through international conferences, international peer-reviewed journals and social media.Trial registration numberISRCTN24998809.
Newly self-administered two-step tool for screening cognitive function in an ageing Chinese population: an exploratory cross-sectional study
Authors: Nie Jing , Yang Yang , Gao Yining , Jiang Wenwen , Aidina Aisikeer , Sun Fei , Prieto Lucas R , Yu Jie , Ju Kang , Song Lisheng , Li Xia 
Published: February 2023

BackgroundEarly screening of cognitive function is critical to dementia treatment and care. However, traditional tests require face-to-face administration and are often limited by implementation costs and biases.AimsThis study aimed to assess whether the Thoven Cognitive Self-Assessment (TCSA), a novel, innovative two-step touchscreen-based cognition assessment tool, could identify early cognitive impairment due to dementia in older adults.MethodsThe TCSA was administered to 61 healthy controls (HCs), 46 participants with mild cognitive impairment (MCI) and 44 participants diagnosed with dementia recruited from Shanghai. Two outcome measures were generated from the TCSA test: the TCSAprimary taskscore and the TCSAsecondary taskscore.ResultsThe total average scores in the control group for the TCSAprimary taskand TCSAsecondary taskwere significantly higher than those in the MCI and dementia groups (TCSAprimary task: HCs vs MCI group vs dementia group, 8.58±1.76 vs 5.40±2.67 vs 2.74±2.11, F=75.40, p<0.001; TCSAsecondary task: HCs vs MCI group vs dementia group, 23.02±3.31 vs 17.95±4.93 vs 11.93±5.50, F=76.46, p<0.001). Moreover, receiver operating characteristic analysis showed that a score below 7.5 for the TCSAprimary taskand a score below 22.5 for the TCSAsecondary taskwere indicators of MCI.ConclusionsThe TCSA appears to be efficacious for the detection of cognitive impairment in older adults. It demonstrates the potential for large-scale cognition screening in community service settings.
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
Authors: Wagner Frank , Mansfield John C , Lekkerkerker Annemarie N , Wang Yehong , Keir Mary , Dash Ajit , Butcher Brandon , Harder Brandon , Orozco Luz D , Mar Jordan S , Chen Hao , Rothenberg Michael E 
Published: February 2023

BackgroundThe interleukin-22 cytokine (IL-22) has demonstrated efficacy in preclinical colitis models with non-immunosuppressive mechanism of action. Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist that links IL-22 to the crystallisable fragment (Fc) of human IgG4for improved pharmacokinetic characteristics, but with a mutation to minimise Fc effector functions.MethodsThis randomised, phase 1b study evaluated the safety, tolerability, pharmacokinetics and pharmacodynamics of repeat intravenous dosing of efmarodocokin alfa in healthy volunteers (HVs; n=32) and patients with ulcerative colitis (n=24) at 30–90 µg/kg doses given once every 2 weeks or monthly (every 4 weeks) for 12 weeks (6:2 active:placebo per cohort).ResultsThe most common adverse events (AEs) were on-target, reversible, dermatological effects (dry skin, erythema and pruritus). Dose-limiting non-serious dermatological AEs (severe dry skin, erythema, exfoliation and discomfort) were seen at 90 μg/kg once every 2 weeks (HVs, n=2; patients, n=1). Pharmacokinetics were generally dose-proportional across the dose levels, but patients demonstrated lower drug exposures relative to HVs at the same dose. IL-22 serum biomarkers and IL-22-responsive genes in colon biopsies were induced with active treatment, and microbiota composition changed consistent with a reversal in baseline dysbiosis. As a phase 1b study, efficacy endpoints were exploratory only. Clinical response was observed in 7/18 active-treated and 1/6 placebo-treated patients; clinical remission was observed in 5/18 active-treated and 0/6 placebo-treated patients.ConclusionEfmarodocokin alfa had an adequate safety and pharmacokinetic profile in HVs and patients. Biomarker data confirmed IL-22R pathway activation in the colonic epithelium. Results support further investigation of this non-immunosuppressive potential inflammatory bowel disease therapeutic.Trial registration numberNCT02749630.
Clinical outcome in patients with suspected inflammatory neuropsychiatric lupus treated with immunosuppression: an observational cohort study
Authors: Monahan Rory C , Beaart-van de Voorde Liesbeth J J , Fronczek Rolf , de Bresser Jeroen , Eikenboom Jeroen , Kloppenburg Margreet , Middelkoop Huub A M , Terwindt Gisela M , van der Wee Nic J A , Huizinga Tom W J , Steup-Beekman Gerda M 
Published: February 2023

BackgroundThe short-term and long-term outcome of inflammatory neuropsychiatric SLE (NPSLE) with immunosuppressive treatment is largely unknown. We used clinical data from our tertiary referral centre for NPSLE to investigate the type of inflammatory NPSLE manifestations, type of immunosuppressive treatment prescribed for these manifestations and clinical outcomes.MethodsAll patients with SLE visiting the Leiden University Medical Centre NPSLE clinic between 2007 and 2021 receiving immunosuppressive therapy for neuropsychiatric symptoms were included. Clinical, immunological and radiological information was collected in as standardised way during a 1-day multidisciplinary assessment. In a multidisciplinary consensus meeting, the presence of NPSLE and the type of NPSLE manifestations and treatment were determined. For this study, short-term (0–6 months) and long-term outcomes (7–24 months) of the NP symptoms were assessed by two independent readers and scored on a 7-point Likert scale, ranging from death to resolved.ResultsIn total, 95 out of 398 (24%) patients visiting the NPSLE clinic between 2007 and 2021 received any form of immunosuppressive treatment for 101 separate NPSLE events. The most common NP manifestation was cognitive dysfunction (50%) as identified by formal cognitive assessment, often present in combination with other NPSLE manifestations. Treatment modalities were induction (24%), induction and maintenance (73%) and other therapy (3%). The treatments mostly consisted of (combinations of) prednisone (97%), methylprednisolone (53%), azathioprine (generally 2 mg/kg daily) (49%) and cyclophosphamide (generally induction 750 mg/m2every 4 weeks for 24 weeks or 500mg biweekly for 12 weeks) (42%). Short-term outcome showed improvement on the Likert scale in 73% (improved: 22%, much improved: 29%, resolved: 22%), no change in 21% and worsening in 6% of patients. Long-term outcome was available for 78 out of 101 events and showed improvement in 70% (improved: 14%, much improved: 28%, resolved: 28%), no change in 17%, worsening in 10% and death in 3% of patients (none directly NPSLE-related).ConclusionThe outcome of inflammatory NPSLE after immunosuppressive treatment is generally good, with improvement of neuropsychiatric symptoms occuring in approximately 70% of events.
Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats
Authors: Hayashi Hiroki , Sun Jiao , Yanagida Yuka , Yoshida Shota , Baba Satoshi , Tenma Akiko , Toyoura Masayoshi , Kawabata Sotaro , Ehara Takako , Asaki Ryoko , Sakaguchi Makoto , Tomioka Hideki , Shimamura Munehisa , Morishita Ryuichi , Rakugi Hiromi , Tomita Tetsuya , Nakagami Hironori 
Published: February 2023

ObjectivesSpondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. Human leucocyte antigen (HLA)-B27 is a genetic risk factor for SpA. Recent evidence suggests that the interleukin −17 (IL17) axis strongly contributes to SpA. This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats.MethodsHLA-B27/human β2-microglobulin (hβ2M) transgenic rats were immunised with heat-inactivatedMycobacterium tuberculosis(MT) to develop spondylitis and arthritis as an experimental SpA model after immunisation with a keyhole limpet hemocyanin-conjugated IL17A peptide-based vaccine with an alum adjuvant three times. The IL17A antibody titre was assessed using ELISA, and arthritis score and joint thickness were monitored two times a week. Enzyme-linked immunospot (ELISpot) assays for IL4- and interferon-γ-secreting splenocytes were conducted to evaluate IL17A-specific T cell activation. We also evaluated the effect of IL17A vaccine in SpA therapeutic model.ResultsThe IL17A peptide-based vaccine with alum adjuvant successfully induced antibody production and suppressed the arthritis score and joint thickness. X-ray and histological analyses showed that enthesitis, bone destruction and new bone formation were inhibited by the IL17A vaccine. The ELISpot assay showed that the IL17A peptide-based vaccine did not elicit any IL17A-reactive T cell responses. IL17A vaccine tends to mitigate, but not significant, in SpA treatment model. These data showed that the peptide-based vaccine targeting IL17A alleviated the SpA phenotype in a heat-inactivated MT-induced SpA model in HLA-B27/hβ2M transgenic rats.ConclusionsIL17A peptide-based vaccine may be a therapeutic option for SpA treatment.
Detecting neutrino-boosted axion dark matter in the MeV gap
Authors: Carenza Pierluca , De la Torre Luque Pedro 
Published: February 2023

AbstractThe elusive nature of Dark Matter (DM) remains a mystery far from being solved. A vast effort is dedicated to search for signatures of feeble DM interactions with Standard Model particles. In this work, we explore the signatures of axion DM boosted by interactions with Supernova neutrinos: Neutrino-Boosted Axion DM ($$\nu $$
ν
BADM). We focus on $$\nu $$
ν
BADM converting into photons in the Galactic magnetic field, generating a peculiar gamma-ray flux. This signal falls in the poorly explored MeV energy range, that will be probed by next generation gamma-ray missions. Once more, astrophysical searches might act as a probe of fundamental physics, unveiling the nature and properties of DM.
$$\sqrt{T\overline{T}}$$-deformed oscillator inspired by ModMax
Authors: García J. Antonio , Sánchez-Isidro R. Abraham 
Published: February 2023

AbstractInspired by a recently proposed Duality and Conformal invariant modification of Maxwell theory (ModMax), we construct a one-parameter family of two-dimensional dynamical systems in classical mechanics that share many features with the ModMax theory. It consists of a couple of $$\sqrt{T\overline{T}}$$

T

T
¯

-deformed oscillators that nevertheless preserves duality $$(q \rightarrow p,p \rightarrow -q)$$

(
q
→
p
,
p
→
-
q
)

and depends on a continuous parameter $$\gamma$$
γ
, as in the ModMax case. Despite its nonlinear features, the system is integrable. Remarkably, it can be interpreted as a pair of two coupled oscillators whose frequencies depend on some basic invariants that correspond to the duality symmetry and rotational symmetry. Based on the properties of the model, we can construct a nonlinear map dependent on $$\gamma$$
γ
that maps the oscillator in 2D to the nonlinear one, but with parameter $$2\gamma$$

2
γ

. The reason behind the existence of such map can be revealed through a construction of two Lax pairs associated with the system. The dynamics also shows the phenomenon of energy transfer and we calculate a Hannay angle associated to geometric phases and holonomies.
Deep Learning for Drawing Numbering in Engineering Drawing Management: A Case Study for Refrigerated Compartment Product
Authors: Zhang Hui , Luo Ruixv , Luo Lanzhen , Li Kun , Fang Xifeng , Zhang Shengwen 
Published: February 2023

Engineering drawing numbering (DN) is one of the most essential procedures for seamless platform integration towards intelligent manufacturing. In spite of this, it is difficult to handle the numbering work in an appropriate and effective manner. This is due to the unpredictability of the names of the manufactured parts and the ineffable relationship between the number and the shape of the parts. This paper proposes a method for numbering items based on historical numbering records based on deep learning. First, name-number (NN) duplexes are generated by retrieving the records. [Formula: see text]-means[Formula: see text] is then used to cluster these NN duplexes. Second, it involves looking up the names of the newly designed items using KNN in order to generate an initial numbering system. Third, a modified multi-view convolutional neural network (MVCNN) is utilized for numbering in situations where the same name is different from the previous number (SNDN). Finally, the most recent sequence numbers are appended to complete the numbering. When the system based on the proposed scheme for authentic engineering application is implemented on a refrigerated compartment, the correctness obtained is over 95%, and the efficiency is increased by 5–6 times.
Contribution of stratigraphy to groundwater motion understanding in chalk: examples of karstogenic horizons of the Pointe de Caux, France
Authors: Gaillard T. , Hoyez B. , Hauchard E. 
Published: February 2023

Abstract
Chalk groundwater is the main renewable drinking water resource for many cities of the Paris–London Basin. Understanding karst groundwater motion enhancement appears to be a major issue in order to better protect drinking water, to define hydrogeological surveys and to explore the aquifer. In Normandy, the stratigraphy of chalk was investigated in the 1970s and 1980s but this newly developed stratigraphy was not introduced to hydrogeology where chalk aquifers are studied without considering the sequence boundaries and key event surfaces. Upper Normandy is a unique hydrogeological region where both stratigraphy and hydrogeology can be studied together. In this article we focus on field observations and their direct application to scientific theory. Eight hydrogeological surfaces, linked to sequence boundaries or key event surfaces, are identified. They increase porosity and permeability sufficiently to develop karstic features, hereafter called karstogenic horizons. These field observations lead us to propose a new stratified chalk groundwater model. Palaeokarsts and perched springs not aligned to the current base level can be explained from a geodynamic perspective. Global eustatism and regional uplift during the Quaternary Period have to be taken into account with the hydrogeological stratified model, as the controlling factors of the groundwater motion and the karstogenic horizon development. This theory will help hydrogeologists to determine the probability of encountering palaeokarsts above the piezometric level and thereby define well locations with a greater degree of confidence according to the karstogenic horizon drilled. Chemical studies may also be applied to show if this stratified model can enhance water quality by a new well design.
Translating Science into Survival: Report on the Sixth International Cancer Immunotherapy Conference
Authors: De Martino Mara , Pancholi Neha J. , Brodsky Arthur N. 
Published: February 2023

Abstract
From September 28 to October 1, 2022, in New York City, the Sixth International Cancer Immunotherapy Conference was hosted jointly by the Cancer Research Institute (CRI), the American Association for Cancer Research, and the European Network for Cancer Immunotherapy. The four-day event covered the latest advances in cancer immunology and immunotherapy.