bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data from Phase II Trial of Temozolomide in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer, with Assessment of Methylguanine-DNA Methyltransferase as a Potential Biomarker
Authors: Pietanza M. Catherine , Kadota Kyuichi , Huberman Kety , Sima Camelia S. , Fiore John J. , Sumner Dyana K. , Travis William D. , Heguy Adriana , Ginsberg Michelle S. , Holodny Andrei I. , Chan Timothy A. , Rizvi Naiyer A. , Azzoli Christopher G. , Riely Gregory J. , Kris Mark G. , Krug Lee M. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> This phase II study was conducted to assess the efficacy of temozolomide in patients with relapsed small cell lung cancer (SCLC).</p><p><b>Experimental Design:</b> Patients with disease progression after one or two prior chemotherapy regimens received temozolomide at 75 mg/m<sup>2</sup>/d for 21 days of a 28-day cycle. The primary endpoint was the overall response rate [ORR; complete response (CR) plus partial response (PR)], which was evaluated separately in sensitive and refractory cohorts. In the available tissue, we assessed <i>O</i><sup>6</sup>-methylguanine-DNA methyltransferase (<i>MGMT</i>) promoter methylation status by PCR and MGMT expression by immunohistochemistry.</p><p><b>Results:</b> Sixty-four patients were accrued: 48 patients in the sensitive cohort and 16 in the refractory group. One CR and 10 PRs were noted in sensitive patients [ORR, 23%; 95% confidence interval (CI), 12%–37%]. Two PRs were seen in the refractory cohort (ORR, 13%; 95% CI, 2%–38%). As second- and third-line treatment, the ORR was 22% (95% CI, 9%–40%) and 19% (95% CI, 7%–36%), respectively. Among patients with target brain lesions, 38% had a CR or PR (95% CI, 14%–68%). Grade ≥3 thrombocytopenia and neutropenia were observed in nine patients (14%). A greater number of cases with methylated <i>MGMT</i> had a response compared to those with unmethylated <i>MGMT</i> (38% vs. 7%; <i>P</i> = 0.08).</p><p><b>Conclusion:</b> Temozolomide has activity in relapsed SCLC, particularly for brain metastases. Response to temozolomide may correlate with <i>MGMT</i> methylation in SCLC. <i>Clin Cancer Res; 18(4); 1138–45. ©2012 AACR</i>.</p></div>
Data from Mass Cytometry Reveals Classical Monocytes, NK Cells, and ICOS<sup>+</sup> CD4<sup>+</sup> T Cells Associated with Pembrolizumab Efficacy in Patients with Lung Cancer
Authors: Rochigneux Philippe , Lisberg Aaron , Garcia Alejandro , Granjeaud Samuel , Madroszyk Anne , Fattori Stéphane , Gonçalves Anthony , Devillier Raynier , Maby Pauline , Salem Nassim , Gorvel Laurent , Chanez Brice , Gukasyan Jaklin , Carroll James , Goldman Jonathan , Chretien Anne Sophie , Olive Daniel , Garon Edward B. 
Published: April 2023

<div>AbstractPurpose:<p>Immune checkpoint inhibitors (ICI) have revolutionized the treatment of non–small cell lung cancer (NSCLC), but predictive biomarkers of their efficacy are imperfect. The primary objective is to evaluate circulating immune predictors of pembrolizumab efficacy in patients with advanced NSCLC.</p> Experimental Design:<p>We used high-dimensional mass cytometry (CyTOF) in baseline blood samples of patients with advanced NSCLC treated with pembrolizumab. CyTOF data were analyzed by machine-learning algorithms (Citrus, tSNE) and confirmed by manual gating followed by principal component analysis (between-group analysis).</p>Results:<p>We analyzed 27 patients from the seminal KEYNOTE-001 study (median follow-up of 60.6 months). We demonstrate that blood baseline frequencies of classical monocytes, natural killer (NK) cells, and ICOS<sup>+</sup> CD4<sup>+</sup> T cells are significantly associated with improved objective response rates, progression-free survival, and overall survival (OS). In addition, we report that a baseline immune peripheral score combining these three populations strongly predicts pembrolizumab efficacy (OS: HR = 0.25; 95% confidence interval = 0.12–0.51; <i>P</i> < 0.0001).</p>Conclusions:<p>As this immune monitoring is easy in routine practice, we anticipate our findings may improve prediction of ICI benefit in patients with advanced NSCLC.</p></div>
Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes
Authors: Monahan Kevin J. , Swinyard Ottilie , Latchford Andrew 
Published: April 2023

AbstractHereditary gastrointestinal cancer is associated with molecular and neoplastic precursors which have revealed much about sporadic carcinogenesis. Therefore, an appreciation of constitutional and somatic events linked to these syndromes have provided a useful model for the development of risk models and preventative strategies. In this review, we focus of two of the best characterized syndromes, Lynch syndrome (LS) and familial adenomatous polyposis (FAP). Our understanding of the neoplasia-immune interaction in LS has contributed to the development of immune mediated therapies including cancer preventing vaccines and immunotherapy for cancer precursors. Chemoprevention in LS with aspirin and nonsteroidal anti-inflammatory drugs has also translated into clinical cancer, however the efficacy of such agents in FAP remains elusive when cancer is applied as an endpoint in trials rather than the use of ‘indirect’ endpoints such as polyp burden, and requires further elucidation of biological mechanisms in FAP. Finally, we review controversies in gastrointestinal surveillance for LS and FAP, including limitations and opportunities of upper and lower gastrointestinal endoscopy in the prevention and early detection of cancer.
Parental stress mediates the effects of parental risk factors on dysfunctional parenting in first-time parents: A dyadic longitudinal study
Authors: Senn Mirjam , Stadelmann Céline , Forster Fabienne , Nussbeck Fridtjof W. , Bodenmann Guy 
Published: April 2023

Both parental psychological well-being (e.g., depressive symptoms) and parental relationship functioning (e.g., negative communication) are common parental risk factors for dysfunctional parenting. The spillover process from these parental characteristics to dysfunctional parenting is assumed to be amplified by parental stress, which is particularly common among mothers and fathers of young children. However, few studies have examined dyadic spillover processes from parental risk factors and parental stress on parenting in early childhood. In the current study, we first examined direct actor and partner effects of parents’ depressive symptoms and negative communication at 10 months postpartum on dysfunctional parenting at 48 months postpartum in 168 primiparous mixed-gender couples. Second, we analyzed indirect effects via one’s own and the partner’s parental stress at 36 months postpartum using Actor-Partner Interdependence Mediation Models (APIMeM). We found direct actor effects for mothers’ depressive symptoms and negative communication on their dysfunctional parenting. Additionally, indirect actor effects were found for depressive symptoms and negative communication among mothers and fathers. Specifically, mediating effects of depressive symptoms and negative communication on one’s dysfunctional parenting through one’s parental stress were found. There were no indirect partner effects through parental stress. These findings highlight the important role of parental stress in early childhood as a mediator between both individual and relationship parental risk factors and dysfunctional parenting. These results further underscore the importance of longitudinal dyadic analyses in providing early and tailored interventions for both mothers and fathers of young children.
Immersive virtual reality: An effective strategy for reducing stress in young adults
Authors: McGarry Sarah , Brown Ashleigh , Gardner Miranda , Plowright Caitlan , Skou Renee , Thompson Craig 
Published: April 2023

Background: Psychological stress is ubiquitous in young adults, but traditional relaxation strategies such as mindfulness or meditation are not consistently utilised. Immersive virtual reality (VR) is being increasingly used in mental health contexts with improved clinical outcomes. However, there is limited research exploring the perceived usefulness of VR for individuals without a mental health diagnosis. Aim: To identify if an immersive VR experience was effective in reducing stress for young adults and to explore the experience of the participants. Methods: Twenty-one young adults aged 18–25 years participated in an immersive VR experience. Heart rate was measured pre- and post-test to objectively establish the efficacy of VR to facilitate relaxation. Participants were invited to participate in a semi-structured interview ( n = 18) to gain a rich understanding of their experience. Results: Four themes emerged from analysis of the interviews: I felt relaxed and calm, It was time-efficient and easy to use, It took me to another place and It was different than I thought it would be. Heart rate reduced during the immersive VR experience. Conclusion: These findings suggest that immersive VR can reduce psychological stress, and it is perceived by young adults as a useful and time-effective strategy to reduce psychological stress.
The role of pragmatics in the definition of evidentiality
Authors: Bergqvist Henrik , Grzech Karolina 
Published: April 2023

AbstractThis paper argues that a definition of evidentiality as a linguistic notion should be based on the pragmatic properties of evidential forms and their distribution in spoken discourse. The prevailing definition of evidentiality as signaling “information source” is based on the idea that evidentials encode a solitary speaker’s perception and cognitive processes, but this definition does not fit well with observations regarding the use and distribution of evidentials. A definition of evidentiality in terms of “information source” has largely disregarded evidentials in-use, which is especially true for typologically oriented studies of evidentiality. Recent descriptions of evidentials and evidential systems have shown that evidentials encode meanings related to ownership of knowledge, rather than information source and it is evident from such descriptions that social and interactional parameters are encoded in evidential forms. The attested semantic and pragmatic complexity of evidential systems constitutes an analytical challenge that the present paper aims to address.
Analisis Risiko Gempa Bumi di Kota Pariaman Provinsi Sumatera Barat
Authors: Baihaqi Rahmad , Pujiastuti Dwi 
Published: April 2023

Telah dilakukan penelitian Analisis Risiko Gempa Bumi di Kota Pariaman Provinsi Sumatera Barat menggunakan metode PSHA (Probabilictic Seismic Hazard Analysis) untuk memetakan risiko gempa bumi. Metode ini dilakukan dengan memperhitungkan ketidakpastian lokasi, ukuran, dan frekuensi terjadinya gempa bumi.Â Data yang digunakan berupa data gempa bumi dari katalog gempa bumi BMKG, IRIS, dan USGS dalam periode waktu tahun 1918-2021. Nilai percepatan gerakan tanah maksimum (PGA) akan dicari menggunakan rumus fungsi atenuasi yang didasarkan pada sumber gempa dengan menggunakan bobot ketidakpastian logic tree. Hasil yang diperoleh untuk nilai b-value sebesar 0,851 menunjukkan kerapuhan batuan pada sumber gempa. Nilai a-value sebesar 6,76 menunjukkan aktivitas seismik yang tinggi. Nilai PGA diperoleh sebesar 0,24-0,53gal di Kota Pariaman. Hasil PGA yang diperoleh menunjukkan bahwa Kota Pariaman memiliki nilai risiko gempa bumi sedang. Nilai Intensitas gempa bumi diperoleh sebesar 5,388-5,907 MMI di Kota Pariaman.
Criteria-Based Rehabilitation Following Revision Hip Arthroscopy: A Clinical Commentary
Authors: Leo Haley , Shelton Trevor , Bradley Helen 
Published: April 2023

Hip revision arthroscopy is becoming an increasingly popular surgery for those with unsatisfactory outcomes following primary hip arthroscopy. With the relatively uncommon but potentially increased difficulty of rehabilitation from this surgery, a lack of established research regarding rehabilitative programs remains. Therefore, the purpose of this clinical commentary is to propose a criterion-based progression that considers the intricacies present following a hip revision arthroscopy from early rehabilitation through return to sport. Criteria are presented clearly to promote objective progression through rehabilitation as opposed to relying on time since surgery as revision surgeries do not always follow traditional tissue healing time-frames. This criterion based progression promotes range of motion (ROM), strength, gait, neuromuscular control, load introduction and gradual return to play. Level of Evidence 5
Muscle Strength, Oxygen Saturation and Physical Activity in Patients with Chronic Exertional Compartment Syndrome Compared to Asymptomatic Controls
Authors: Tønning Lisa Urup , Mygind-Klavsen Bjarne , Kjeldsen Troels , Dalgas Ulrik , Brincks John , Mechlenburg Inger 
Published: April 2023

Background One of the most common causes of exercise-induced pain in the lower leg is chronic exertional compartment syndrome (CECS). Research is limited on muscle strength, oxygen saturation and physical activity in patients with CECS. Purpose To compare muscle strength, oxygen saturation, and daily physical activity between patients with CECS and matched asymptomatic controls. A secondary purpose was to investigate the association between oxygen saturation and lower leg pain in patients with CECS. Study Design Case-control study. Method Maximal isometric muscle strength of the ankle plantar and dorsiflexors was tested in patients with CECS and sex- and age-matched controls using an isokinetic dynamometer and oxygen saturation (StO2) during running was tested by near infrared spectroscopy. Perceived pain and exertion were measured during the test using the Numeric Rating Scale and Borg Rating of Perceived Exertion scale and the exercise-induced leg pain questionnaire. Physical activity was assessed by accelerometry. Results Twenty-four patients with CECS and 24 controls were included. There were no differences in maximal isometric plantar or dorsiflexion muscle strength between patients and controls. Baseline StO2 was 4.5pp (95% CI: 0.7;8.3) lower for patients with CECS than for controls, whereas no difference existed when they experienced pain or reached exhaustion. No differences were found in daily physical activities, except that on average, patients with CECS spent less time cycling daily. During the StO2 measurement, patients experienced pain or reached exhaustion while running significantly earlier than the controls (p<0.001). StO2 was not associated with leg pain. Conclusion Patients with CECS have similar leg muscle strength, oxygen saturation and physical activity levels as asymptomatic controls. However, patients with CECS experienced significantly higher levels of lower leg pain than the controls during running, daily activities and at rest. Oxygen saturation and lower leg pain were not associated. Level of Evidence Level 3b.
Ecological and Specific Evidence-Based Safe Return To Play After Anterior Cruciate Ligament Reconstruction In Soccer Players: A New International Paradigm
Authors: Forelli Florian , Le Coroller Nicolas , Gaspar Maxime , Memain Geoffrey , Kakavas Georgios , Miraglia Nicholas , Marine Patrice , Maille Pascal , Hewett Timothy E , Rambaud Alexandre JM 
Published: April 2023

Existing return to play (RTP) assessments have not demonstrated the ability to decrease risk of subsequent anterior cruciate ligament (ACL) injury after reconstruction (ACLR). RTP criteria are standardized and do not simulate the physical and cognitive activity required by the practice of sport. Most RTP criteria do not include an ecological approach. There are scientific algorithms as the “5 factor maximum model” that can identify risk profiles and help reduce the risk of a second anterior cruciate ligament injury. Nevertheless, these algorithms remain too standardized and do not include the situations experienced in games by soccer players. This is why it is important to integrate ecological situations specific to the environment of soccer players in order to evaluate players under conditions closest to their sporting activity, especially with high cognitive load. One should identify high risk players under two conditions: Clinical analyses commonly include assessments such as isokinetic testing, functional tests (hop tests, vertical force-velocity, profile), running, clinical assessments (range of motion and graft laxity), proprioception and balance (Star Excursion Balance Test modified, Y-Balance, stabilometry) and psychological parameters (kinesophobia, quality of life and fear of re-injury). Field testing usually includes game simulation, evaluation under dual-task conditions, fatigue and workload analysis, deceleration, timed-agility-test and horizontal force-velocity profiles. Although it seems important to evaluate strength, psychological variables and aerobic and anaerobic capacities, evaluation of neuromotor control in standard and ecological situations may be helpful for reducing the risk of injury after ACLR. This proposal for RTP testing after ACLR is supported by the scientific literature and attempts to approximate the physical and cognitive loads during a soccer match. Future scientific investigation will be required to demonstrate the validity of this approach. Level of Evidence 5
The Development of a Return to Performance Pathway Involving A Professional Soccer Player Returning From A Multi-Structural Knee Injury: A Case Report
Authors: Mitchell Andrew , Waite Ollie , Holding Craig , Greig Matt 
Published: April 2023

This case report describes a male professional soccer player returning to match play (English Championship League) following a medial meniscectomy that occurred during the course of rehabilitation after Anterior Cruciate Ligament (ACL) reconstruction. The player underwent a medial meniscectomy eight months into an ACL rehabilitation program and following 10 weeks of rehabilitation successfully returned to competitive first team match play. This report outlines description of the pathology, the rehabilitation progressions, and the sports specific performance requirements of the player as they progressed through the return to performance pathway (RTP). The RTP pathway included nine distinct phases with evidenced based criteria required to exit each phase. The first five phases were indoor as the player progressed from the medial meniscectomy, through the rehabilitation pathways to the “gym exit Phase”. The gym exit Phase was assessed with multiple criteria: a) capacity; b) strength; c) isokinetic dynamometry (IKD); d) hop test battery; e) force plate jumps; and f) supine isometric hamstring rate of force (RFD) development qualities to evaluate the players readiness to start sport specific rehabilitation. The last four phases of the RTP pathway are designed to regain the maximal physical capabilities (plyometric and explosive qualities) in the gym and included the retraining of on-field sport specific qualities utilizing the ‘control-chaos continuum.’ The player successfully returned to team play in the ninth and final phase of the RTP pathway. The purpose of this case report was to outline a RTP for a professional soccer player who successfully restored specific injury criteria (strength, capacity and movement quality), physical capabilities (plyometric and explosive qualities). and on-field sport specific criteria utilizing the ‘control-chaos continuum.’ Level of Evidence Level 4
Self-Movement Screening using the Symmio Application is Reliable and Valid for Identifying Musculoskeletal Risk Factors
Authors: Matsel Kyle , Kirsch Jonathan , Netelbeek Tessa , Rodriguez Rolando , Velic Ervin , Schwartzkopf-Phifer Kate 
Published: April 2023

Background Musculoskeletal health problems are one of the greatest healthcare expenses in the United States but patient-driven screening procedures to detect risk factors do not exist. Hypothesis/Purpose The purpose was to establish the inter-rater reliability of the Symmio Self-Screen application in untrained individuals and to investigate its accuracy to detect MSK risk factors such as pain with movement, movement dysfunction, and decreased dynamic balance. Study Design Cross-Sectional Methods Eighty (42 male, 38 female) healthy individuals mean age 26.5 ± 9.4 participated in the study. The inter-rater reliability of Symmio application was established by comparing self-screen scores from untrained subjects with the results simultaneously determined by a trained healthcare provider. Each subject was evaluated for pain with movement, movement dysfunction, and deficits in dynamic balance by two trained evaluators who were blinded to the Symmio results. The validity of Symmio was determined by comparing self-screen performance dichotomized as pass or fail with the reference standard of pain with movement, failure on the Functional Movement Screen™, and asymmetry on the Y Balance Test-Lower Quarter™ using three separate 2x2 contingency tables. Results The mean Cohen’s kappa coefficient was 0.68 (95% CI, 0.47-0.87) and the absolute agreement was 89% between self-assessment of subjects and the observation of a trained healthcare provider. There were significant associations for the presence of pain with movement (p=0.003), movement dysfunction (p=0.001), and dynamic balance deficits (p=0.003) relative to poor Symmio performance. The accuracy of Symmio to identify pain with movement, movement dysfunction, and dynamic balance deficits were 0.74 (95% CI, 0.63-0.83), 0.73 (95% CI, 0.62-0.82), and 0.69 (95% CI, 0.57-0.79), respectively. Conclusions The Symmio Self-Screen application is a reliable and feasible screening tool that can be used to identify MSK risk factors. Level of Evidence Level 2
The Effect Of Percussive Therapy On Musculoskeletal Performance And Experiences Of Pain: A Systematic Literature Review
Authors: Sams Lorna , Langdown Ben L , Simons Joan , Vseteckova Jitka 
Published: April 2023

Background There is a lack of specific research on the effect of percussive therapy (PT) delivered by massage guns on physiological adaptations. This systematic literature review investigates research conducted on the effects of PT interventions on performance in strength and conditioning settings, and on experiences of musculoskeletal pain. Purpose To determine the effect of PT delivered by massage guns on physiological adaptations: muscle strength, explosive muscle strength and flexibility, and experiences of musculoskeletal pain. Study Design Systematic literature review. Methods Data sources (CINAHL, Cochrane Library, Psychinfo, PubMed, SportDISCUS and OpenGrey) were searched from January 2006 onwards for full text literature in any language involving adult populations receiving PT delivered by massage guns, directly to any muscle belly or tendon, with comparisons to an alternative treatment, placebo or no treatment. Literature with outcomes relating to acute or chronic physiological adaptations in muscle strength, explosive muscle strength, flexibility or experiences of musculoskeletal pain were included. Articles were assessed for quality using the Critical Appraisal Skills Programme and PEDro scores. Results Thirteen studies met the inclusion criteria. All studies had limitations in methodological quality or reporting of findings but still included contextually-rich details that contributed to the overall narrative synthesis. A significant relationship was found between a single application of PT delivered by massage guns and an acute increase in muscle strength, explosive muscle strength and flexibility, with multiple treatments eliciting a reduction in experiences of musculoskeletal pain. Conclusion PT delivered by massage guns can help improve acute muscle strength, explosive muscle strength and flexibility, and reduce experiences of musculoskeletal pain. These devices may provide a portable and cost-effective alternative to other forms of vibration and interventions.