bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convolutional Neural Networks: A Promising Deep Learning Architecture
for Biological Sequence Analysis
Authors: John Chinju , Sahoo Jayakrushna , Madhavan Manu , Mathew Oommen K. 
Published: March 2023

Abstract:
The deep learning arena explores new dimensions once considered impossible to human intelligence.
Recently, it has taken footsteps in the biological data world to deal with the diverse patterns
of data derived from biomolecules. The convolutional neural networks, one of the most employed and
persuasive deep learning architectures, can unravel the sequestered truths from these data, especially
from the biological sequences. These neural network variants outperform traditional bioinformatics
tools for the enduring tasks associated with such sequences.

:
This work imparts an exciting preface to the basics of convolutional neural network architecture and
how it can be instrumented to deal with biological sequence analysis.

:
The approach followed in this paper can provide the reader with an enhanced view of convolutional
neural networks, their basic working principles and how they apply to biological sequences.

:
A detailed view of critical steps involved in deep learning, starting from the data preprocessing, architecture
designing, model training, hyperparameter tuning, and evaluation metrics, are portrayed. A
comparative analysis of convolutional neural network architectures developed for protein family classification
is also discussed.

:
This review contributes significantly to understanding the concepts behind deep learning architectures
and their applications in biological sequence analysis. It can lift the barrier of limited knowledge to a
great extent on the deep learning concepts and their implementation, especially for people who are dealing
with pure biology.
piRSNP: A Database of piRNA- related SNPs and their Effects on Cancerrelated
piRNA Functions
Authors: Liu Yajun , Li Aimin , Zhu Yingda , Pang Xinchao , Hei Xinhong , Xie Guo , Wu Fang-Xiang 
Published: March 2023

Backgroud:
PIWI-interacting RNAs (piRNAs) are a kind of small non-coding RNAs
which interact with PIWI proteins and play a vital role in safeguarding genome. Single nucleotide polymorphisms
(SNPs) are widely distributed variations which are associated with diseases and have rich
information. Up to now, various studies have proved that SNPs on piRNA were related to diseases.

Objective:
In order to create a comprehensive source about piRNA-related SNPs, we developed a publicly
available online database piRSNP.

Methods:
We systematically identified SNPs on human and mouse piRNAs. piRSNP contains
42,967,522 SNPs on 10,773,081 human piRNAs and 29,262,185 SNPs on 16,957,706 mouse piRNAs.

Results:
7,446 SNPs on 519 cancer-related piRNAs and their flanks are investigated. Impacts of 2,512
variations of cancer-related piRNAs on piRNA-mRNA interactions are analyzed.

Conclusion:
All these useful data and piRNA expression profiles of 12 cancer types in both tumor and
pericarcinomatous tissues are compiled into piRSNP. piRSNP characterizes human and mouse piRNArelated
SNPs comprehensively and could be beneficial for researchers to investigate subsequent piRNA
functions. Database URL is http://www.ibiomedical.net/piRSNP/.
Curbing Rhes Actions: Mechanism-based Molecular Target for
Huntington’s Disease and Tauopathies
Authors: Subramaniam Srinivasa , Boregowda Siddaraju 
Published: March 2023

Abstract::
A highly interconnected network of diverse brain regions is necessary for the precise execution
of human behaviors, including cognitive, psychiatric, and motor functions. Unfortunately, degeneration
of specific brain regions causes several neurodegenerative disorders, but the mechanisms that
elicit selective neuronal vulnerability remain unclear. This knowledge gap greatly hinders the development
of effective mechanism-based therapies, despite the desperate need for new treatments. Here,
we emphasize the importance of the Rhes (Ras homolog-enriched in the striatum) protein as an emerging
therapeutic target. Rhes, an atypical small GTPase with a SUMO (small ubiquitin-like modifier)
E3-ligase activity, modulates biological processes such as dopaminergic transmission, alters gene expression,
and acts as an inhibitor of motor stimuli in the brain striatum. Mutations in the Rhes gene
have also been identified in selected patients with autism and schizophrenia. Moreover, Rhes SUMOylates
pathogenic form of mutant huntingtin (mHTT) and tau, enhancing their solubility and cell toxicity
in Huntington's disease and tauopathy models. Notably, Rhes uses membrane projections resembling
tunneling nanotubes to transport mHTT between cells and Rhes deletion diminishes mHTT
spread in the brain. Thus, we predict that effective strategies aimed at diminishing brain Rhes levels
will prevent or minimize the abnormalities that occur in HD and tauopathies and potentially in other
brain disorders. We review the emerging technologies that enable specific targeting of Rhes in the
brain to develop effective disease-modifying therapeutics.
Review on Applicability and Utilization of Blockchain Technology in
Ubiquitous Computing
Authors: Singh Ramander , Kumar Tyagi Rajesh , Kumar Mishra Anil , Choudhury Umakant 
Published: March 2023

Abstract:
In typical Internet of Things (IoT) networks, data is sent from sensors to fog devices
and then onto a central cloud server. One single point of failure, a slowdown in the flow of data,
identification, security, connection, privacy concerns caused by a third party managing cloud
servers, and the difficulty of frequently updating the firmware on millions of smart devices from
both a maintenance and a security point of view are just some of the problems that can occur. The
evolution of ubiquitous computing and blockchain technology has inspired researchers worldwide
in recent years. Key features of blockchain technology, such as the fact that it can't be changed
and a decentralised and distributed approach to data security, have made it a popular choice for
developing diverse applications. With the practically significant applicability of blockchain concepts
(specifically consensus methods), modern-day applications in ubiquitous computing and
other related areas have significantly benefited. In addition, we have taken advantage of the widely
available blockchain platforms and looked into potential new study fields. As a result, this review
paper elaborates the novel alternative privacy preservation options while simultaneously focusing
on the universal domain as a starting point for blockchain technology applications. We also
discuss obstacles, research gaps, and solutions. This review can assist early researchers who
are beginning to investigate the applicability of blockchain technology in ubiquitous computing. It
is also possible to use it as a reference in order to speed up the process of finding the appropriate
markers for ongoing research subjects that are of interest.
Associations Between Smartphone Keystroke Metadata and Mental Health Symptoms in Adolescents: Findings From the Future Proofing Study
Authors: Braund Taylor A , O’Dea Bridianne , Bal Debopriyo , Maston Kate , Larsen Mark , Werner-Seidler Aliza , Tillman Gabriel , Christensen Helen 
Published: March 2023

Background
Mental disorders are prevalent during adolescence. Among the digital phenotypes currently being developed to monitor mental health symptoms, typing behavior is one promising candidate. However, few studies have directly assessed associations between typing behavior and mental health symptom severity, and whether these relationships differs between genders.

Objective
In a cross-sectional analysis of a large cohort, we tested whether various features of typing behavior derived from keystroke metadata were associated with mental health symptoms and whether these relationships differed between genders.

Methods
A total of 934 adolescents from the Future Proofing study undertook 2 typing tasks on their smartphones through the Future Proofing app. Common keystroke timing and frequency features were extracted across tasks. Mental health symptoms were assessed using the Patient Health Questionnaire-Adolescent version, the Children’s Anxiety Scale-Short Form, the Distress Questionnaire 5, and the Insomnia Severity Index. Bivariate correlations were used to test whether keystroke features were associated with mental health symptoms. The false discovery rates of P values were adjusted to q values. Machine learning models were trained and tested using independent samples (ie, 80% train 20% test) to identify whether keystroke features could be combined to predict mental health symptoms.

Results
Keystroke timing features showed a weak negative association with mental health symptoms across participants. When split by gender, females showed weak negative relationships between keystroke timing features and mental health symptoms, and weak positive relationships between keystroke frequency features and mental health symptoms. The opposite relationships were found for males (except for dwell). Machine learning models using keystroke features alone did not predict mental health symptoms.

Conclusions
Increased mental health symptoms are weakly associated with faster typing, with important gender differences. Keystroke metadata should be collected longitudinally and combined with other digital phenotypes to enhance their clinical relevance.

Trial Registration
Australian and New Zealand Clinical Trial Registry, ACTRN12619000855123; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377664&isReview=true
PREDISPOSIÇÃO À INOVAÇÃO FRUGAL: ANÁLISE DE FATORES DIFERENCIAIS EM PEQUENAS E MÉDIAS EMPRESAS
Authors: Thais Alves Karen , Nodari Cristine Hermann , Bohnenberger Maria Cristina , Gilberto Aloise Pedro 
Published: March 2023

Objetivo: Analisar como as pequenas e médias empresas (PME´s), aproximam-se da inovação frugal considerando os fatores diferenciais de agregar valor, otimizar processos, capital humano e modelo de negócios.
Método/abordagem: Pesquisa descritiva de casos múltiplos. A análise dos dados coletados, seguiu o proposto por Gibbs (2009), considerando quatro fatores diferenciais, identificados na literatura, como norteadores categóricos para a interpretação dos resultados.
Principais Resultados: Aponta-se que os quatro fatores apresentados nesta pesquisa, representam um campo de possibilidades, não apenas no desenvolvimento de produtos e serviços frugais que atendem as necessidades dos clientes, mas de um processo maior, que estimulem as PME´s a se desenvolverem sustentavelmente, contribuindo para competitividade e maturidade nos negócios.
Contribuições teóricas/práticas/sociais: O estudo possibilita aos gestores a compreensão na identificação e desenvolvimento de suas capacidades organizacionais com o intuito de melhorar o negócio, permitindo, que as PME´s conquistem novos clientes, novos mercados, atuem com a limitação de recursos, reduzindo seus custos e aperfeiçoando seus processos.
Originalidade/relevância: O investimento em pesquisa empírica ao encontro das sugestões de estudos que argumentam a necessidade de avançar os debates existentes sobre a inovação frugal, principalmente em se tratando de empresas de pequeno e médio porte.
New Study on the History of Russian Liberal Centrism in the Early 20th Century Review of Tsentrizm v rossiiskom liberalizme nachala XX veka [Centrism in Russian liberalism in the early 20th century] by N.B. Khailova (Moscow: Institut rossiiskoi istorii RAN; Tsentr gumanitarnykh initsiativ, 2022)
Authors: Егоров А.Н. 
Published: March 2023

Анализируется монография старшего научного сотрудника Центра «Истории России ХIХ – начала ХХ вв.» Института российской истории РАН Нины Борисовны Хайловой, посвященная центризму в российском либерализме начала ХХ в. Рецензируемая работа является первым в историографии комплексным исследованием данной проблемы. Показано, что в монографии на основании широкого круга источников, часть из которых была опубликована ее автором, досконально исследован весь комплекс вопросов, касающихся организационных особенностей, социальной базы, программных и тактических установок, основных направлений и особенностей думской и внепарламентской деятельности центристских либеральных партий. Отмечена существенная роль приложения к монографии – биографического словаря, включающего сведения об основных деятелях либерального центризма начала ХХ в. Подчеркивается серьезный вклад рецензируемой монографии в изучение истории российского либерализма.
The article analyzes the monograph by Nina B. Khailova, a senior researcher at the Centre for the History of Russia in the 19th – early 20th Centuries of the Institute of Russian History of the Russian Academy of Sciences, dedicated to centrism in Russian liberalism in the early 20th century. The work under review is the first comprehensive study of this problem in historiography. It has been shown that based on a wide range of sources, some of which were published by its author, the monograph thoroughly studies the whole complex of issues concerning organizational features, social base, programmatic and tactical attitudes, and the main directions and features of the Duma and extra-parliamentary activities of centrist liberal parties. The reviewer notes an essential role of the appendix to the monograph (which is a biographical dictionary that includes information about the main figures of the liberal centrism of the early 20th century) and emphasizes a significant contribution of the monograph under review to the study of the history of Russian liberalism.
Guerras generalizadas, capital e encarceramento no Brasil
Authors: Oliveira Agnes de , Silva Gabriel de Araujo 
Published: March 2023

A acumulação desenfreada no capitalismo historicamente se deu concomitantemente à constituição de uma máquina de guerra generalizada, guerra civil permanente que se desdobra como guerras securocráticas, guerras de subjetividades, guerras raciais, guerras aos pobres e guerras multiespécies. Veremos como essas guerras viabilizam as relações econômicas, inter-raciais e de gênero, sendo condicionantes internas da própria acumulação monetária e das categorias que estruturam o capitalismo: trabalho, mercadoria, dinheiro, Estado etc. Posteriormente, com vistas à situar o encarceramento como forma de efetivação da máquina de guerra do capital, será realizada uma breve genealogia do antagonismo ao cárcere da passagem do século XX à atualidade, um tema comumente invisibilizado, demonstrando como a assimilação das oposições ao cárcere, como a incorporação da oposição política nas políticas de expansão prisional e às facções na gestão prisional, são fundamentais para as dinâmicas de governo da guerra permanente. Por fim, trataremos das últimas consequências da expansão da federalização das facções e milícias, que encontram seu paroxismo na região amazônica, expandindo dinâmicas simultaneamente criminais e conectadas ao capitalismo global, como o tráfico internacional, o garimpo, a grilagem de terras, o contrabando de madeiras, o extermínio de espécies animais e vegetais, que tem propiciado uma explosão de violência, assassinatos, racialização e proletarização de populações na região amazônica.
Palavras-chave: Guerra; Cárcere; Amazônia; Racismo; Gênero.
Spatial distribution of soil nutrient content for sustainable rice agriculture using geographic information system and Naïve Bayes classifier
Authors: Yudhana Anton , Cahyo Andreyan Dwi , Sabila Liya Yusrina , Subrata Arsyad Cahya , Mufandi Ilham 
Published: March 2023

Abstract
This study aims to assist farmers in monitoring soil nutrients, especially phosphorus. To measure the phosphorus content of paddy soil, the TCS3200 converter, as an intelligent sensor, was applied. The geographical information system (GIS) was also involved in this research to map the phosphorus content. In addition, the Naïve Bayes method was applied to classify lowland soil phosphorus status. The result of this study indicated that the Naïve Bayes algorithm could classify lowland soil phosphorus status with a probability of 0.34 for moderate phosphorus conditions and 0.66 for high phosphorus conditions. The sample testing results showed that the error rate was 3% and the success rate was 97%. Testing with a phosphorus-measuring instrument can be carried out by mapping the soil phosphorus status with the ArcGIS software, whereby seven points of medium-phosphorus-status paddy soil and 13 locations of high-phosphorus-status soil samples were determined. This research thus successfully mapped the soil phosphorus.
Primera parte de la investigación sobre los resultados del uso de las tecnologías de la información antes, durante y después de la pandemia
Authors: Gutiérrez Bonilla Rosa Ela , Martínez Acuña Manuel Ignacio 
Published: March 2023

El objetivo de este artículo será conocer la manera en la que los docentes de tiempo completo, de la FCAS, se adaptaron y pudieron salir adelante, ante el reto de modificar sus técnicas de enseñanza aprendizaje de una forma presencial, a otra en la cual muy pocos se habían atrevido a adentrarse, la educación virtual o a distancia. En el presente artículo se explica la manera en la cual se realizará esta investigación: primeramente, se hablará del entorno en el que se encontraban los docentes de la FCAS antes y durante la pandemia, el objetivo de la investigación, la metodología que se utilizará; en esta parte se explicará el universo que se empleará como báse, para después establecer la técnica elegida para determinar la muestra, posteriormente se presentará el instrumento que se utilizará para recolectar la información. Es importante aclarar que está investigación presenta la primera parte.
EPOXIDACIÓN DE ACEITE DE HIGUERILLA (Ricinus communis) DE LA PROVINCIA DE MANABÍ-ECUADOR
Authors: Baque P. Genesis , Intriago F. Anthony , García M. Segundo , Burgos B. Gabriel , García V. Gonzalo 
Published: March 2023

El aceite de higuerilla (Ricinnus communis) atrae el interés en la industria química porque puede emplearse como materia prima para producir productos químicos o fuentes de energía por medio de modificaciones químicas, como es el caso de la epoxidación. El presente estudio, de índole investigativa y experimental, se enfoca en la epoxidación del aceite de higuerilla de la variedad Portoviejo-67 de la provincia de Manabí- Ecuador por medio de la reacción de Prileschajew para evaluar las características fisicoquímicas del aceite crudo y epoxidado mediante las normas ASTM D-5558, EN 14111, NTC 2366 para índice de saponificación, índice de yodo e índice de acidez mediante técnicas de titulación, norma INEN 39 para contenido de humedad mediante pérdida por calentamiento, norma ASTM D-1217 para densidad por picnometría y viscosidad cinemática por medio de un viscosímetro capilar mediante la norma ASTM D-445 comparando los resultados con las especificaciones ASTM y DIN ISO 51605: 2010-09. Según los resultados, el aceite crudo y epoxidado cumplen las especificaciones ASTM y DIN ISO 51605: 2010-09 a excepción de la humedad y la acidez con valores superiores a 0,075 % y 2 mg KOH/g de aceite, respectivamente, representando una disminución en la calidad de los aceites, referente a la epoxidación se obtuvo una conversión del 81,34 % de las insaturaciones y de acuerdo a la viscosidad se pudo clasificar el aceite epoxidado con un grado ISO VG 320 ideal para lubricación de engranajes industriales. Se concluye que se logró alcanzar una alta conversión de los dobles enlaces a grupos epoxi, siendo el proceso ideal para obtener altos rendimientos.
Perkuatan Seismik Struktur Gedung Berlantai Tujuh Menggunakan Sistem Bresing Baja
Authors: Setiawan Alhadi , Hasan Muttaqin , Saidi Taufiq 
Published: March 2023

<p class="11daftarpustaka" align="center"><strong>Abstrak</strong></p><p class="11daftarpustaka"> </p><p class="11daftarpustaka">Struktur Gedung BSI Cut Mutia Banda Aceh mengalami beberapa retakan pada balok dan kolom akibat gempa sehingga memerlukan suatu perkuatan dengan menganalisis struktur menggunakan metode <em>pushover</em> untuk mengetahui gaya geser dan <em>displacement</em> maksimum yang mampu ditahan oleh struktur pada kondisi eksisting maupun setelah diperkuat menggunakan bresing dan level kinerja serta mekanisme sendi plastis maupun simpangan antar lantai. Untuk pengembangan kurva kerapuhan digunakan metode <em>Incremental Dynamic Analysis</em> (IDA) untuk melihat tingkat probabilitas kerusakan struktur dari 10 rekaman gempa. Data yang diperlukan yaitu gambar perencanaan awal, mutu baja, mutu beton dan dimodelkan menggunakan software SAP2000, dilakukan analisis statis beban mati dan beban hidup serta analisis dinamis. Hasil penelitian menunjukkan profil bresing baja IWF 150x150x10x7 memenuhi keamanan untuk sistem perkuatan. Simpangan antar lantai menggunakan bresing lebih kecil dari pada kondisi eksisting serta evaluasi <em>displacement</em> dan <em>drift ratio</em> dari data riwayat gempa lebih rentan terhadap beban gempa Simeulue 1 dengan nilai PGA 1,281 g.</p><p class="11daftarpustaka"> </p><p class="11daftarpustaka">Kata kunci: Perkuatan Seismik, Pushover, Time History, IDA, Kurva Kerapuhan<em></em></p><p> </p><p class="11daftarpustaka" align="center"> </p><p class="11daftarpustaka" align="center"><strong>Abstract</strong></p><p class="11daftarpustaka"> </p><p class="11daftarpustaka">The structure of the BSI Cut Mutia Banda Aceh Building has several cracks in the beams and columns due to the earthquake, so it requires strengthening by analyzing the structure using the pushover method to determine the maximum shear and displacement forces that the structure can withstand in the existing conditions and after being strengthened using braces and performance levels as well as the mechanism of plastic hinges and drift between floors. The development of the fragility curve uses the Incremental Dynamic Analysis (IDA) method to show the probability level of structural damage from 10 recorded earthquakes. The data needed are initial planning drawings, steel quality, concrete quality and modeled using SAP2000 software, static analysis of dead and live loads and dynamic analysis is carried out. The results showed that the steel bracing profile IWF 150x150x10x7 met safety for reinforcement systems. The deviation between floors using braces is smaller than the existing conditions and the displacement and drift ratio evaluation from historical earthquake data is more susceptible to the Simeulue 1 earthquake load with a PGA value of 1.281 g.</p><p class="11daftarpustaka"> </p><p class="11daftarpustaka">Keywords: <em>Seismic Strengthening, Pushover, Time History, IDA, Fragility Curve.</em></p>
PELATIHAN SERTIFIKASI BALAI BESAR POM DAN HALAL BAGI POKLAHSAR RUMAH LELE ATHALLAH SERTA SIVITAS AKADEMIK UNIVERSITAS SUMATERA SELATAN
Authors: Guttifera Guttifera , Sari Selly Ratna , Rizki Rani Ria , Yovandre Egi 
Published: March 2023

Pelaku Usaha (UMKM) harus memperhatikan persyaratan keamanan di sepanjang rantai pasok agar masyarakat terjamin kesehatan dan keamanannya saat mengkonsumsi produk. Setiap konsumen muslim akan memperhatikan kehalallan suatu produk sebelum dikonsumsi, bahkan menjadi kebutuhan yang wajib. Salah satu permasalahan yang membuat daya saing UMKM masih rendah terbatasnya kemampuan para pelaku usaha terdaftar dalam BPOM dan Halal pada kemasan produk. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan Standar Keamanan Produk komersil bersertifikasi BPOM dan Halal. Kegiatan pelatihan dilakukan di Kampus C universitas Sumatera Selatan, Jakabaring, Banyuasin, Sumatera Selatan. Hasil dari Kegiatan yang dilakukan adalah pelatihan pendaftaran dalam mengurus izin edar BPOM dan pelatihan persyaratan untuk mendapatkan sertifikasi Halal pada produk para pelaku UMKM. Kegiatan yang dilaksanakan pada saat pelatihan dihadiri 50 peserta yang terdiri dari Dosen Universitas Sumatera Selatan, anggota pohlaksar rule athallah dan mahasiswa Universitas Sumatera Selatan. Kesimpulan yang diperoleh adalah kegiatan pelatihan sertifikasi BPOM dan sertifikasi Halal dapat menambah pengetahuan para pelaku usaha Poklasar Rule Athallah, serta mengetahui tentang produk yang diproduksi tidak boleh menyerupai sesuatu yang berbau haram, baik penamaan maupun bahan yang digunakan.