bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile one-pot green synthesis of almond gum coated MgO nanoparticles for Biological applications
Authors: Ganapathi Meenu Pragathi , Balasubramanian Balamuralikrishnan , Chinnasamy Balalakshmi 
Published: January 2023

Abstract
The increasing resistance of pathogens and cancer cells to antibiotics and anticancer drugs has sparked the discovery of novel therapeutic materials. Recently, the utilization of plant compounds and byproducts in nanomaterials fabrications has great attention in biomedicine and bioremediation. In this work, almond gum coated MgO nanoparticles were synthesized by a simple green synthesis method. The physicochemical properties of prepared nanoparticles were systematically evaluated using various microscopic and spectroscopy techniques. The biological potential of AG@MgO nanoparticles was evaluated against human infectious pathogens, (Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae). The anticancer potential of nanoparticles was assessed against MCF-7 a breast cancer cell which shows excellent cell damage in the lowest concentration. The larvicidal potential of nanoparticles was evaluated against Aedes aegypti mosquito larvae, the mortality rate of larvae increases as the concentration ratio of AG@MgO nanoparticles increases. The final results concluded that the AG@MgO nanoparticles efficiently control bacterial, breast cancer cell growth, and mosquito larvae.
Improved methods for characterizing emulsions by Nuclear Magnetic Resonance
Authors: Sørland Geir Humborstad , Less Simone , Alkhabbaz Sajjad , Simon Sébastien 
Published: January 2023

Abstract

The use of Nuclear Magnetic Resonance (NMR) is an appropriate tool for studying colloids in a non-invasive manner. Droplet size distributions and one-dimensional sample profiles are readily produced to characterize an emulsion, its stability, the size distribution of the dispersed phase, and rheological behavior with respect to parameters as temperature and/or water cut. Here, we present Pulsed Field Gradient NMR methods that improve the performance as compared to existing methods. In particular, the so-called multi-echo approach is introduced to enhance the signal to noise ratio significantly making it possible to characterize emulsions in a minute or less. Thus, any evolution that takes place in the order of just a few minutes can be monitored. In addition to the multi-echo approach, an improved method for determining the droplet size distribution from a residual emulsion, i.e. in the presence of a bulk water phase, is presented.
Internet-based stress recovery intervention for adolescents: study protocol for a randomized controlled trial
Authors: Zelviene Paulina , Kairyte Agniete , Dumarkaite Austeja , Nomeikaite Auguste , Kazlauskas Evaldas 
Published: January 2023

Abstract
Background. Mental health in adolescence are highly related to life-stressors exposure and difficulties in adjusting to stressors. Research reveals a high prevalence of stressors in adolescence. Therefore, interventions for recovery from stress are in high demand. The study aims to evaluate the efficacy of the internet-based stress recovery intervention for adolescents.
Methods: A two-arm randomized controlled trial (RCT) on the efficacy of the FOREST-A – an internet-based stress recovery intervention for adolescents – will be conducted. The FOREST-A is an adapted version of stress recovery intervention initially developed for healthcare workers. FOREST-A is a third-wave cognitive behavioral therapy and mindfulness-based internet-delivered 4-week psychosocial intervention, which comprises six modules: Introduction, Relaxation, Psychological detachment, Mastery, Control, and Summary. The intervention will be evaluated using the two-arm RCT with intervention and care as usual (CAU) condition at pre-test, post-test, and 3-month follow-up. The measured outcomes will be stress recovery, adjustment disorder, generalized anxiety and depression symptoms, psychological well-being, and perceived positive social support.
Discussion: The study will contribute to the development of internet interventions – easily and broadly accessible tools – for the enhancement of adolescents' recovery from stress skills. Based on the study's findings, further development of the FOREST-A, including upscaling and implementation, is foreseen.
Trial registration: ClinicalTrials.gov NCT05688254. Registered on January 6, 2023.
Outcome of COVID-19 patients with haematological malignancies after the introduction of vaccination and monoclonal antibodies: results from the HM-COV 2.0 study
Authors: Oliva Alessandra , Dezza Francesco Cogliati , Petrucci Flavia , Romani Francesco Eugenio , Morviducci Matteo , Mirabelli Flavio Marco , Cancelli Francesca , Valeriani Emanuele , Marcelli Giulia , Pugliese Francesco , Turriziani Ombretta , Ricci Paolo , Venditti Mario , Palange Paolo , Mastroianni Claudio Maria 
Published: January 2023

AbstractPurpose. Patients with hematological malignancies (HM) and SARS-CoV-2 infection present a higher risk of severe COVID-19 and mortality. The aim of the study was to investigate whether vaccination and monoclonal antibodies (mAbs) have modified the outcomes of HM patients with COVID-19.Methods. Single-center retrospective study in HM patients hospitalized due to SARS-CoV-2 infection from March 2020 to April 2022. Patients were divided into PRE-V-mAb group (patients hospitalized before the introduction of vaccination and mAbs) and POST-V-mAb group (patients hospitalized after the use of vaccine and mAbs).Results. A total of 126 patients were included (65 PRE-V-mAb and 61 POST-V-mAb). POST-V-mAb patients showed a significantly lower risk of Intensive Care Unit (ICU) admission (8.2% vs 27.7%, p=0.005), shorter viral shedding [17 (IQR 10-28) vs 24 days (IQR 15-50), p=0.011] and shorter hospitalization length [13 (IQR 7-23) vs 20 (IQR 14-41) days, p=0.0003] compared to the PRE-V-mAb group. Nevertheless, both in-hospital and 30-day mortality rates did not significantly differ between the two groups (29.5% POST-V-mAb vs 36.9% PRE-V-mAb and 21.3% POST-V-mAb vs 29.2% PRE-V-mAb, respectively). At the multivariable analysis an active malignancy (p=0.042), a critical COVID-19 at admission (p=0.025) and the need for high-level of oxygen support at respiratory worsening [either HFNC/CPAP (p=0.022) or Mechanical Ventilation (p=0.011)] were independently associated with in-hospital mortality. In the subgroup of POST-V-mAb patients, receiving therapy with mAbs was a protective factor (p=0.033).Conclusion. Despite the new therapeutic and preventive strategies available, HM patients with COVID-19 disease represent an extremely vulnerable group with still high mortality rates.
Cross-section measurements for 68Zn(p,2p)67Cu and 68Zn(p,2n)67Ga reactions using a newly developed separation method for the superposed γ-ray spectra
Authors: Jung Myung-Hwan , Cho Won-Je , Jang Hye Min , Chun Kwon-Soo , Lee Jae Sang , Kim Sang Wook , Park Jun Kue 
Published: January 2023

Abstract
We have developed a new analytical peak separation analysis for superposed γ-ray peaks on 67Cu and 67Ga to measure the 68Zn(p,2p)67Cu and 68Zn(p,2n)67Ga reactions, unlike in most previous works that were employing a radiochemical separation to measure them. Based on the nuclear data such as the γ-ray intensity and the half-life for each nuclide, we may develop a new analytical method that enables us to estimate the respective counts arising from each nuclide, thereby obtaining the nuclear reactions. In comparison with the data in the literature, the two reactions in the present work are in good agreement with those of some previous works. In addition, we compared the present 68Zn(p,2n)67Ga reaction without the peak separation to the data in the literature without the chemical separation, and find that a good agreement is evident, enhancing the reliability of the 68Zn(p,x)65Zn and 68Zn(p,3n)66Ga reactions, which are further measured in the present work.
2D/3D Ultrasound Diagnosis of Pediatric Distal Radius Fractures by Human Readers vs Artificial Intelligence
Authors: Knight Jessica , Zhou YuYue , Keen Christopher , Hareendranathan Abhilash Rakkunedeth , Alves-Pereira Fatima , Ghasseminia Siyavash , Wichuk Stephanie , Brilz Alan , Kirschner David , Jaremko Jacob 
Published: January 2023

Abstract
Wrist trauma is common in children and generally requires radiography for exclusion of fractures, subjecting children to radiation and long wait times in the emergency department. Ultrasound (US) has potential to be a safer, faster diagnostic tool. This study aimed to determine how reliably US could detect distal radius fractures in children, to contrast the accuracy of 2DUS to 3DUS, and to assess the utility of artificial intelligence for image interpretation. 127 children were scanned with 2DUS and 3DUS on the affected wrist. US scans were then read by 7 blinded human readers and an AI model. With radiographs used as the gold standard, expert human readers obtained a mean sensitivity of 0.97 and 0.98 for 2DUS and 3DUS respectively. The AI model sensitivity was 0.91 and 1.00 for 2DUS and 3DUS respectively. Study data suggests that 2DUS is comparable to 3DUS and AI diagnosis is comparable to human experts.
Evolutionary dynamics of glue gene copy number in Drosophila species
Authors: Monier Manon , Nuez Isabelle , Borne Flora , Courtier-Orgogozo Virginie 
Published: January 2023

Abstract
Background
During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine how several Sgs genes encoding glue proteins, which make up a bioadhesive that sticks the animal during metamorphosis, have evolved in Drosophila species.
Results
We examined high-quality genome assemblies of 24 Drosophila species to study the evolutionary dynamics of the Sgs1-Sgs3-Sgs7-Sgs8 family glue genes at an unprecedented resolution across approximately 30 millions of years. A total of 102 Sgs genes were annotated and grouped into 4 subfamilies. We present here a new nomenclature for Sgs genes based on protein sequence conservation, genomic location and presence/absence of internal repeats. Two types of glue genes were uncovered. The first category (Sgs1, Sgs3X, Sgs3e) experienced a few gene losses but no duplication, no local inversion and no gene conversion. The second group (Sgs3b, Sgs7, Sgs8) exhibited multiple events of gene losses, gene duplications, local inversions and gene conversions. Our data suggest that the presence of short "new glue" genes near the genes of the latter group may have accelerated their dynamics.
Conclusions
Our comparative analysis suggests that the evolutionary dynamics of glue genes is influenced by genomic context. Our molecular, phylogenetic and comparative analysis of the glue gene family Sgs1-Sgs3-Sgs7-Sgs8 provides the foundation for investigating the role of the various glue genes during Drosophila life.
Revisiting the karyotype of the social wasp Polistes canadensis (Linnaeus, 1758) (Hymenoptera: Vespidae: Polistinae)
Authors: Pinheiro Tailan Silva , Santos Rafael de Jesus , Bitencourt Jamille de Araújo , Miranda Adrianne Oliveira , Junior Juvenal Cordeiro Silva 
Published: January 2023

Abstract

Cytogenetic techniques have been improving over the last decades, providing useful information for the systematics and evolution of several groups, such as social insects. On the other hand, karyotypic data are still incipient for most wasp genera. For instance, only five of the 240 species of Polistes have been karyotyped, usually based on obsolete data. Therefore, this study aimed to revisit the karyotype structure of Polistes canadensis, providing unpublished information based on traditional (karyotyping and C-banding) and refined (GC- and AT-rich sites by base-specific fluorochrome staining) cytogenetic methods. Males and females of P. canadensis were characterized by haploid and diploid numbers of n = 28 and 2n = 56, respectively. The karyotype formula was established in 2K = 18M + 22SM + 16A with a predominance of pericentromeric heterochromatin and terminal GC+ sites in 16 chromosome pairs. Our results differ significantly from the previous karyotype reported for this species, probably related to the utilization of suitable methods of obtaining mitotic chromosomes in the present study. In addition, the detailed analysis of chromosomal microstructure provided potential cytotaxonomic markers for systematic inferences in social wasps.
Irrational parenthood cognition and infertility stigma among infertile women: a cross- sectional study in Changsha, China
Authors: Tang Qin , Zhou Xiu , Wang Nan , Qian Xiangzi 
Published: January 2023

Abstract

Background
Stigma is among the most prevalent and disturbing consequences of being infertile among women, yet it remains unknown whether fertility stigma is affected by irrational parenthood cognitions. The current study aimed to assess irrational parenthood cognitions, infertility stigma, and their interrelationship among a group of Chinese women referred to an infertility center in Changsha, Hunan, China.
Methods
In this cross-sectional study, 376 women seeking treatment for infertility at three hospitals in Changsha City were recruited and completed online questionnaires through the questionnaire star from October 2020 to January 2021. Irrational parenthood cognitions and infertility stigma were assessed by the Irrational parenthood cognitions (IPC) scale and Infertility Stigma Scale (ISS), respectively. Pearson correlation test was used to explore the association between IPC and ISS, while multivariate linear regression was used to explore the independent influencing factors of stigma.
Results
Participants had a mean score of 42.41 ± 13.03 for IPC and 62.89 ± 24.50 for ISS. Irrational parenthood cognitions were highly correlated with infertility stigma with a large effect size (r = 0.55, p < 0.001). Multivariate linear regression showed that patients’ infertility stigma was positively associated with irrational parenthood cognitions (β = 1.06, p < 0.001), while negatively associated with education (β=-5.4, p = 0.036) and disclosure of infertility (β= -8.39, p = 0.001).
Conclusion
This study is the first to identify a positive association between irrational parenthood cognitions and infertility stigma among infertile women in China. Our findings provide useful guidance for the future development of effective anti-stigma intervention programs among infertile women.
Can preoperative magnetic resonance imaging be used for sagittal kyphotic flexibility assessment in patients with kyphosis secondary to symptomatic old osteoporotic thoracolumbar fracture?
Authors: Wang kangkang , zhang Feng , Zhai Yunlei , Zhang Wei , Yin Wen , Sun Lele , Cui Xilong , Yu Haiyang 
Published: January 2023

Abstract
Objective This study aimed to investigate whether preoperative magnetic resonance imaging (MRI) can be used for sagittal kyphotic (SK) flexibility assessment in patients with kyphosis secondary to symptomatic old osteoporotic thoracolumbar fracture (so-OTLF).
Methods The authors evaluated the radiographic data of patients with kyphosis secondary to so-OTLF. All patients underwent posterior corrective fusion surgery in the hospital. Spinal sagittal parameters were measured on standing radiographs preoperatively. The regional kyphosis angle (RKA) was also measured on preoperative supine MRI and intraoperative prone radiographs on the surgical frame. The SK flexibility in patients with kyphosis secondary to so-OTLF was defined as the difference between the RKA measured on the standing radiographs and that measured on the intraoperative prone radiographs or preoperative supine MRI. The difference and the correlation between the SK flexibility measured by these two methods were compared and analyzed.
Results Thirty-seven patients were included. The RKA measured on standing radiographs, supine MRI, and intraoperative prone radiographs were 48.03°, 34.40°, and 31.95°, respectively. Compared with the RKA measured in standing position, the RKA measured on supine MRI decreased by 13.63° (95% confidence interval 11.44°– 15.82°), whereas that measured on intraoperative prone radiographs decreased by 16.08° (95% confidence interval 13.66°–18.50°). A linear correlation existed between the SK flexibility measured on supine MRI and that measured on intraoperative prone radiographs, with a mean difference of 2.44° (R2 = 0.912, p<0.001).
Conclusion The degree of regional kyphosis deformity was reduced by self-reduction of the intraoperative surgical frame. With a predictive value similar to an intraoperative prone radiograph, preoperative supine MRI can be used for SK flexibility assessment in patients with kyphosis secondary to so-OTLF. The ability to predict the intraoperative degree of regional kyphosis deformity with positioning before an operation helps with surgical planning and patient counseling regarding expectations and risks of surgery.
Aseptic loosening of tumor endprostheses in distal femur after revision surgery: a retrospective study
Authors: Li Ziming , Yu Xiuchun , Xu Ming , Zheng Kai , Hou Ziwei , Miao Zukang , Sun Yanshun 
Published: January 2023

Abstract
Background: More patients are having revision surgery because of aseptic loosening of tumor prostheses in distal femur, but the revision failure rate is also increasing, which is mainly due to the recurrence of aseptic loosening. The purpose of this study was to analyze the risk factors for recurrence of aseptic loosening after revision surgery of tumor prosthesis in the distal femur.
Method: A retrospective analysis was performed on 23 patients who had revision surgery for distal femur prosthesis due to aseptic loosening between June 2002 and June 2021. They were divided into two groups based on the condition of the prostheses after revision surgery: loosening group and control group. After the initial replacement, length and diameter of the prosthetic intramedullary stem were measured. The osteotomy length, femoral length and diameter, femoral intramedullary stem diameter, hip–knee–ankle angle (HKAA), mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA) and so on were measured as well. Following that, statistical analysis was performed.
Results: Patients in the loosening group had statistically significant differences in the ratio of prosthesis length to femur length (71.89±6.62) and the ratio of intramedullary stem diameter to medullary cavity diameter (25.50±6.90) (P < 0.05) when compared to the control group. The HKAA (175.58°±2.78°), mLDFA (94.42°±2.57°), and the deviation angle between the force line of the lower limb and the longitudinal axis of the tibial prosthesis (2.23°±1.09°) in the loosening group were significantly different from those in the control group (P < 0.05) on postoperative radiographs of the entire length of the lower limbs. The lowest score in intramedullary manubrium I indicated less osteolysis, while the highest score in intramedullary manubrium Ⅲ indicated the most serious osteolysis, and the difference was statistically significant (P < 0.05).
Conclusions: We conclude that using longer and thicker intramedullary stems can effectively reduce the incidence of aseptic loosening, and that using the original prosthesis carefully can reconstruct the standard line of lower limb force. The distal segment of the intramedullary stem is more prone to osteolysis and should be closely follow-up after surgery.
A massively successful experience is needed for spontaneous use in post-stroke: a randomized controlled trial
Authors: Kim Sujin , Shin Yumi , Jeong Yeonwoo , Na Seungyoung , Han Cheol E 
Published: January 2023

Abstract

Background:Motivation to use the more-affected arm is an essential indicator of recovery in stroke survivors. This study aimed to investigate whether personal mastery experience via intensive repetitive reaching movements with autonomy support may increase self-efficacy and thus increase performance and use of the more-affected arm in mild-to-moderate subacute to chronic stroke patients.
Methods:Twenty-six participants with stroke were divided into two groups: a motivation group (with autonomy support) and a control group (without autonomy support). Five weeks of training and test sessions were administered using the individualized motivation enhancement system that we developed. The task difficulty parameter modulated the time limit for attaining targets to provide autonomy support. We analyzed various clinical and behavioral measures using mixed-effect models.
Results:Successful experiences did not change in the control group (p = .129),but dramatically increased in the motivation group (p < .0001). Performance significantly improved in the retention test for both groups (p < .0001), without any group differences (p = .329). However, the motivation group exhibited a dramatic increase in the use of the more-affected arm (p < .0001), whereas the control group did not (p
Conclusions: The successful experience of personal mastery accomplished by autonomy support increased the use of the affected arm. Autonomy support in the motivation group may make a participant aware of the training goal: to use the more-affected arm as much as possible or make the affected arm use more habitual.
Trial registration: The study was registered with The Clinical Research Information Service (CRIS), KCT0008117. Registered retrospectively on January 13, 2023, at https://cris.nih.go.kr/cris/search/detailSearch.do/23875
Risk factors for Interruption in Treatment among HIV-infected adolescence attending health care and treatment clinics in Tanzania
Authors: Mtisi Expeditho L. , Mushy Stella E. , Mkawe Simon G. , Ndjovu Antony , Mboggo Eric , Ngalesoni Frida , Muya Aisa 
Published: January 2023

Abstract
Background
Interruption in Treatment (IIT) is a challenge in HIV care and treatment programs in sub- Saharan Africa. We analyzed risk factors for IIT among HIV-positive adolescence receiving care and treatment in Tanga region, Tanzania. The findings will help to guide the development of strategies targeting adolescents to improve retention of patients in care and treatment services.
Methods
We conducted retrospective longitudinal cohort study using secondary data of adolescent patients enrolled in care and treatment clinics in Tanga from October 2018 to December 2020. We defined Interuption in Treatment as missing clinic visits for 90 consecutive days after the last scheduled appointment date on anti-retroviral therapy (ART). Cox proportional hazard regression models were employed to identify risk factors of the outcome variable.
Results
Among 2,084 adolescents of age between 15 to 19 years were followed for two years, whereby 546 (26.2%) had interrupted treatment. The median age of the participants was 14.6 years (interquartile range, IQR: 12.6–16.6 years), with age between 15 to 19 years, male sex, with advanced HIV disease and were not on Dolutegravir (DTG) related regimens were associated with interruption in treatment; (Hazard ratio (HR) 1.43, 95% CI 1.23–1.66, p < 0.0001, HR 2.47, 95% CI 1.62–3.77, p < 0.0001, HR: 2.47, 95% CI 1.91– 3.21, p < 0.0001 and HR: 6.67, 95% CI 3.36– 7.04, p < 0.0001 respectively). Adolescents who were on ART for less or equal one year compared to those on ART for more than one year were protective toward interruption in treatment (HR: 0.68, 95% CI 0.54–0.87, p = 0.002).
Conclusions
The risk of interruption in treatment was high among adolescents in HIV care and treatment facilities in Tanga. This might lead to poor clinical outcomes, and increased drug resistance among ART-initiated adolescents. Placing more adolescents with DTG based drug, strengthening access to care and treatment and rapid tracking of patients is recommended to improve patient outcomes.