bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
Authors: Wei Wei , Yao Jiu-xiu , Zhang Ting-ting , Wen Jia-yu , Zhang Zhen , Luo Yi-miao , Cao Yu , Li Hao 
Published: May 2023

ObjectiveTo investigate the mechanism underlying the effects of berberine (BBR) in the treatment of Alzheimer’s disease (AD).Methods3 × Tg AD mice were treated with BBR for 3 months, then the open field test (OFT), the novel object recognition test (NOR) and the Morris water maze (MWM) test were performed to assess behavioral performance. Hematoxylin–eosin (HE) staining, Nissl staining were used to examine histopathological changes. The pharmacological and molecular properties of BBR were obtained from the TCMSP database. BBR-associated AD targets were identified using the PharmMapper (PM), the comparative toxicogenomics database (CTD), DisGeNet and the human gene database (GeneCards). Core networks and BBR targets for the treatment of AD were identified using PPI network and functional enrichment analyses. AutoDock software was used to model the interaction between BBR and potential targets. Finally, RT-qPCR, western blotting were used to validate the expression of core targets.ResultsBehavioral experiments, HE staining and Nissl staining have shown that BBR can improve memory task performance and neuronal damage in the hippocampus of AD mice. 117 BBR-associated targets for the treatment of AD were identified, and 43 genes were used for downstream functional enrichment analysis in combination with the results of protein–protein interaction (PPI) network analysis. 2,230 biological processes (BP) terms, 67 cell components (CC) terms, 243 molecular function (MF) terms and 118 KEGG terms were identified. ALB, EGFR, CASP3 and five targets in the PI3K-AKT signaling pathway including AKT1, HSP90AA1, SRC, HRAS, IGF1 were selected by PPI network analysis, validated by molecular docking analysis and RT-q PCR as core targets for further analysis. Akt1 mRNA expression levels were significantly decreased in AD mice and significantly increased after BBR treatment (p &lt; 0.05). Besides, AKT and ERK phosphorylation decreased in the model group, and BBR significantly increased their phosphorylation levels.ConclusionAKT1, HSP90AA1, SRC, HRAS, IGF1 and ALB, EGFR, CASP3 were core targets of BBR in the treatment of AD. BBR may exert a neuroprotective effect by modulating the ERK and AKT signaling pathways.
Quality control in resting-state fMRI: the benefits of visual inspection
Authors: Lepping Rebecca J. , Yeh Hung-Wen , McPherson Brent C. , Brucks Morgan G. , Sabati Mohammad , Karcher Rainer T. , Brooks William M. , Habiger Joshua D. , Papa Vlad B. , Martin Laura E. 
Published: May 2023

BackgroundA variety of quality control (QC) approaches are employed in resting-state functional magnetic resonance imaging (rs-fMRI) to determine data quality and ultimately inclusion or exclusion of a fMRI data set in group analysis. Reliability of rs-fMRI data can be improved by censoring or “scrubbing” volumes affected by motion. While censoring preserves the integrity of participant-level data, including excessively censored data sets in group analyses may add noise. Quantitative motion-related metrics are frequently reported in the literature; however, qualitative visual inspection can sometimes catch errors or other issues that may be missed by quantitative metrics alone. In this paper, we describe our methods for performing QC of rs-fMRI data using software-generated quantitative and qualitative output and trained visual inspection.ResultsThe data provided for this QC paper had relatively low motion-censoring, thus quantitative QC resulted in no exclusions. Qualitative checks of the data resulted in limited exclusions due to potential incidental findings and failed pre-processing scripts.ConclusionVisual inspection in addition to the review of quantitative QC metrics is an important component to ensure high quality and accuracy in rs-fMRI data analysis.
Child health screening program in French nursery schools: Results and related socioeconomic factors
Authors: Milcent Karen , Gassama Malamine , Dufourg Marie-Noëlle , Thierry Xavier , Charles Marie-Aline , Bois Corinne 
Published: May 2023

ObjectivesThe study aims to describe the output of routine health screening performed in French nursery schools by the maternal and child health services among children aged 3–4 years and to quantify the level of early socioeconomic health disparities.MethodsIn 30 participating départements, data on screening for vision and hearing impairments, overweight and thinness, dental health, language, psychomotor development, and immunizations were collected for children born on specific dates in 2011 and enrolled in nursery school in 2014–2016. Information was collected on the children, their socioeconomic characteristics and on the school attended. Odds of abnormal screening results were compared for each socioeconomic factor by logistic regressions adjusted for age, sex, prematurity and bilingualism.ResultsAmong the 9,939 children screened, prevalence of disorders was 12.3% for vision, 10.9% for hearing, 10.4% for overweight, 7.3% for untreated caries, 14.2% for language and 6.6% for psychomotricity. Newly detected visual disorders were more frequent in disadvantaged areas. Children with unemployed parents were three time more likely to have untreated caries and twice as likely to present language or psychomotor impairments; 52% were referred to a health professional following screening compared to 39% of children with employed parents. Except for children in disadvantaged areas, vaccine coverage was lower among disadvantaged groups.ConclusionThe prevalences of impairments, which are higher among disadvantaged children, highlight the potential preventive impact of systematic screening under the comprehensive maternal and child healthcare program. These results are important to quantify early socioeconomic inequalities in a Western country known for its generous social welfare system. A more holistic approach to child health is needed with a coherent system involving families and aligning primary care, local child health professionals, general practitioners, and specialists. Further results are needed to evaluate its impact on later child development and health.
Efficacy and safety of abrocitinib for moderate-to-severe atopic dermatitis in adolescents and adults: Meta-analysis
Authors: Li Ling , Yu Jiajun , Chen Baoqing , Guo Ying , Yang Yufeng 
Published: May 2023

Objective: This study aims to investigate the safety and efficacy of abrocitinib in treating moderate-to-severe AD in adolescents and adults.Methods: Pubmed, Cochrane, Embase, and Web of science data base were searched from inception to 9 August 2022. All randomized controlled trials (RCTs) evaluating the efficacy and safety of abrocitinib in moderate to severe AD were included in the meta-analysis.Results: This meta-analysis comprised 7 studies and found that 100 mg or 200 mg of abrocitinib significantly improved IGA {[RR = 2.44, 95% CI (1.93–3.08)] [RR = 3.16, 95% CI (2.52–3.96)]} and EASI-75{[RR = 2.18, 95%CI (1.78–2.67)] [RR = 3.04, 95%CI (2.22–4.16)]} responses compared to placebo. Following that, the population was divided into adolescent and adult groups. The abrocitinib improved IGA, EASI-75 responses, and it was still superior to placebo in both the adolescent and the adult groups. PP-NRS4 response index demonstrated that abrocitinib had a greater effect than placebo at 100 mg [RR = 2.22, 95% CI 1.80–2.72] and 200 mg [RR = 3.28, 95% CI 2.59–4.17]. Abrocitinib improved PSAAD, POEM, DLQI, CDLQI, and HADS more than a placebo.Conclusion: In conclusion, this meta-analysis preliminarily demonstrated that abrocitinib had higher efficacy and safety in the treatment of moderate-to-severe AD in adolescents and adults. In addition, abrocitinib could rapidly relieve itching, and effectively improve symptoms and signs, with a greater effect at the dosage of 200 mg than 100 mg.
Effectiveness and safety of vedolizumab for ulcerative colitis: a single-center retrospective real-world study in China
Authors: Huang Kaituo , Liu Jing , Xia Wenhao , Tian Chuwen , Yao Lingya , Cao Qian , Chen Haotian 
Published: May 2023

Introduction: The effectiveness and safety of vedolizumab (VDZ) against ulcerative colitis (UC) have been validated in several randomized controlled trials and real-world studies in Western countries. However, there are few studies on VDZ in Asia, and the follow-up period for these studies is generally short. Therefore, this study evaluates the long-term effectiveness and safety of VDZ in Chinese patients with UC.Methods: This retrospective study included patients with moderate to severe UC treated with VDZ between September 2019 and April 2022 at Sir Run Run Shaw Hospital, College of Medicine Zhejiang University. Clinical response and remission were assessed using the patient reported outcomes and the partial Mayo Score, and mucosal remission and healing were assessed using the Mayo Endoscopy Score. The primary endpoint was defined as clinical remission at week 14, and secondary endpoints included clinical response and steroid-free clinical remission at week 14, clinical response, clinical remission, and steroid-free clinical remission at week 52, and mucosal remission and healing at weeks 14 ± 8 and 52 ± 8.Results: Overall, 64 patients with moderate to severe UC were enrolled. The clinical response, clinical remission, and steroid-free clinical remission rates at week 14 were 73.4% (47/64), 65.6% (42/64), and 54.7% (35/64), respectively. Mucosal remission and healing rates at week 14 ± 8 were 64.7% (22/34) and 38.2% (13/34), respectively. A total of 48 patients were treated with VDZ for 52 weeks. Based on intention-to-treat analysis, the clinical response, clinical remission, and steroid-free clinical remission rates at week 52 were 68.8% (44/64), 64.1% (41/64), and 64.1% (41/64), respectively. Mucosal remission and healing rates at week 52 ± 8 were 70.6% (12/17) and 35.3% (6/17), respectively. During the follow-up period, the most common adverse event was skin rash (6/64). No cases of acute infusion reactions, delayed allergic reactions, new hepatitis B infections, active tuberculosis, or malignant tumors were reported.Conclusion: In this single-center retrospective real-world study, the effectiveness of long-term use of VDZ for Chinese patients with UC was similar to the outcomes previously reported in other geographical regions and populations; no new safety signals were found compared with other registered studies.
Exploring the different cognitive, emotional and imaginative experiences of autistic and non-autistic adult readers when contemplating serious literature as compared to non-fiction
Authors: Chapple Melissa , Davis Philip , Billington Josie , Corcoran Rhiannon 
Published: May 2023

IntroductionRecent research has demonstrated how reflections on serious literature can challenge dominant social-deficit views of autism. This method enables autistic readers to explore social realities more slowly and carefully, encouraging detail-focused considerations. Previous research has also shown that autistic and non-autistic readers reflecting on serious literature together are able to achieve mutuality in a way that enables them to overcome the double empathy problem. However, the advantages of reading aloud designs have yet to be explored with autistic and non-autistic readers due to previous concerns amongst autistic people on the issue of being read aloud to. The present study aimed to explore how an adapted shared reading design that compared serious literature and non-fiction would enable autistic and non-autistic readers to imaginatively engage in the reading experience.MethodsSeven autistic and six non-autistic participants read 8 short text extracts alone while listening to pre-recorded audio of an experienced reader reading each text aloud. Participants completed a reflective questionnaire for each text and a follow-up interview where moving parts of the text were then re-read aloud before discussion. Half of these texts were serious literature, while the other half were non-fiction. Similarly, half of the texts explored fictional social realities that depicted a lack of mutuality, or non-fiction accounts of autism; while the other half explored broader emotional experiences.ResultsThematic and literary analysis of participant reflections and follow-up interviews revealed three main themes: (1) From Surface Reading to Intuitive Engagement, (2) Imaginative Feeling and (3) Going Forward from the Reading Experience.DiscussionThe findings showed that autistic readers were better able to hold onto the detailed complexity of serious literature, while non-autistic readers tended to reduce information down to key ideas and understandings for later generalization. Findings are discussed in relation to future shared reading designs.
The wrong horse was bet on: the effects of argument structure versus argument adjacency on the processing of idiomatic sentences
Authors: Reimer Laura , Smolka Eva 
Published: May 2023

IntroductionPsycholinguistic research remains puzzled about the circumstances under which syntactically transformed idioms keep their figurative meaning. There is an abundance of linguistic and psycholinguistic studies that have examined which factors may determine why some idioms are more syntactically fixed than others, including transparency, compositionality, and syntactic frozenness; however, they have returned inconclusive, sometimes even conflicting, results. This is the first study to examine argument structure (i.e., the number of arguments a verb takes) and argument adjacency (i.e., the position of the critical arguments relative to the verb) and their effects on the processing of idiomatic and literal sentences in German. Our results suggest that neither the traditional models of idiom processing (according to which idioms are stored as fixed entries) nor more recent hybrid theories (which concede some compositional handling in addition to a fixed entry) adequately account for the effects of argument structure or argument adjacency. Therefore, this study challenges existing models of idiom processing.MethodsIn two sentence-completion experiments, participants listened to idiomatic and literal sentences in both active and passive voice without the sentence-final verb. They indicated which of three visually-presented verbs best completed the sentence. We manipulated the factor argument structure within experiments and argument adjacency across experiments. In Experiment 1, passivized three-argument sentences had the critical argument adjacent to the verb while two-argument sentences had the critical argument non-adjacent to the verb, and vice versa in Experiment 2.ResultsIn both experiments, voice interacted with argument structure. Active sentences—both literal and idiomatic—showed equivalent processing of two- and three-argument sentences. However, passive sentences returned contrasting effects. In Experiment 1, three-argument sentences were processed faster than two-argument sentences and vice versa in Experiment 2. This pattern corresponds to faster processing when critical arguments are adjacent than non-adjacent.DiscussionThe results point to the dominant role of argument adjacency over the number of arguments in the processing of syntactically transformed sentences. Regarding idiom processing, we conclude that the adjacency of the verb to its critical arguments determines whether passivized idioms keep their figurative meaning and present the implications of this finding for relevant models of idiom processing.
A systematic review of handover actions in human dyads
Authors: Kopnarski Lena , Rudisch Julian , Voelcker-Rehage Claudia 
Published: May 2023

IntroductionHandover actions are joint actions in which an object is passed from one actor to another. In order to carry out a smooth handover action, precise coordination of both actors’ movements is of critical importance. This requires the synchronization of both the kinematics of the reaching movement and the grip forces of the two actors during the interaction. Psychologists, for example, may be interested in studying handover actions in order to identify the cognitive mechanisms underlying the interaction of two partners. In addition, robotic engineers may utilize insights from sensorimotor information processing in human handover as models for the design controllers in robots in hybrid (human-robot) interaction scenarios. To date, there is little knowledge transfer between researchers in different disciplines and no common framework or language for the study of handover actions.MethodsFor this reason, we systematically reviewed the literature on human-human handover actions in which at least one of the two types of behavioral data, kinematics or grip force, was measured.ResultsNine relevant studies were identified. The different methodologies and results of the individual studies are here described and contextualized.DiscussionBased on these results, a common framework is suggested that, provides a distinct and straightforward language and systematics for use in future studies. We suggest to term the actors as giver and receiver, as well as to subdivide the whole action into four phases: (1) Reach and grasp, (2) object transport, (3) object transfer, and (4) end of handover to comprehensively and clearly describe the handover action. The framework aims to foster the necessary exchange between different scientific disciplines to promote research on handover actions. Overall, the results support the assumption that givers adapt their executions according to the receiver’s intentions, that the start of the release of the object is processed feedforward and that the release process is feedback-controlled in the transfer phase. We identified the action planning of the receiver as a research gap.
Proculturation shaped by social representations of academic migrants from Italy to the United States
Authors: Dryjanska Laura 
Published: May 2023

IntroductionExisting literature has highlighted the phenomenon of academic migrants leaving Italy for the United States with the hope of finding institutions that offer more opportunities for growth and recognition based on merit, as opposed to corruption, nepotism, and excessive bureaucracy. Likely, these may be the expectations of Italian academic migrants, who seem to be thriving and flourishing in their careers. This paper discusses proculturation of academic migrants from Italy to the United States, in the light of their expectations related to self-concept as well as social representations of North American university instructors from transnational families.MethodsIn this study, 173 participants volunteered to provide information in an online survey that included their demographic profile, family situation, language ability, recalled pre-migration expectations and preparations, satisfaction with life, self-perceived stress, self-rated health, free responses to questions about major successes, challenges, and goals, as well as self-identification.ResultsThe results have shown that participants were indeed thriving in their careers and lives (majority scored high in satisfaction with life, health, realistic expectations and helpful per-migration preparations, while low in stress, also indicating work-related accomplishments and successes), but somewhat struggled with proculturation-related issues, frequently mentioned among major challenges.
Analysis of factors affecting the construction duration of public health emergency medical facilities
Authors: Zhao Wenchao , He Haibo 
Published: May 2023

ObjectivesThis study explores the factors influencing the construction duration of public health emergency medical facilities and the ways in which they can be enhanced.MethodsCombining 30 relevant emergency medical facility construction cases in different cities in China from 2020 to 2021, seven condition variables and an outcome variable were selected, and necessary and sufficient condition analyses of duration influence factors were conducted using the fsQCA method.ResultsThe consistency of seven condition variables was &lt;0.9, which shows that the construction period of public health emergency medical facilities is not independently affected by a single condition variable but by multiple influencing factors. The solution consistency value of the path configurations was 0.905, indicating that four path configurations were sufficient for the outcome variables. The solution coverage of the four path configurations was 0.637, indicating that they covered ~63.7% of the public health emergency medical facility cases.ConclusionTo reduce the construction duration, the construction of emergency medical facilities should focus on planning and design, the selection of an appropriate form of construction, the reasonable deployment of resources, and the vigorous adoption of information technology.
Semilocal convergence conditions for the secant method, using recurrent functions
Authors: Argyros Ioannis K. , Hilout Saïd 
Published: May 2023

Using our new concept of recurrent functions, we present new
sufficient convergence conditions for the secant method
to a locally unique solution of a nonlinear equation
in a Banach space. We combine Lipschitz and center-Lipschitz
conditions on the divided difference operator to obtain the
semilocal convergence analysis of the secant method. Our error
bounds are tighter than earlier ones. Moreover, under our
convergence hypotheses, we can expand the applicability of the
secant method in cases not covered before [8],
[9], [12]-[14], [16], [19]-[21]. Application and examples are also
provided in this study.
Improving complexity of Karmarkar's approach for linear programming
Authors: Benterki Djamel , Bouafia Mousaab 
Published: May 2023

In this paper, we are interested in the performance of Karmarkar's projective algorithm for linear programming. Based on the work of Schrijver, we offer a new displacement step better than Schrijver's one which led to a moderate improvement in the behavior of the algorithm shift. We show later that the algorithm converges after \(\frac{n}{1-\log\left( 2\right) +(\frac{nr^{2}}{10})}\log\big( \frac{c^{t}e_{n}}{\varepsilon}\big) \) iterations.
This purpose is confirmed by numerical experiments showing the efficiency of the obtained algorithm, which are presented in the end of the paper.
Kalp Yetmezliği Hastalarının Sağ Kalım Tahmini: Sınıflandırmaya Dayalı Makine Öğrenmesi Algoritmalarının Bir Uygulaması
Authors: BOZKURT KESER Sinem , KESKİN Kemal 
Published: May 2023

Kardiyo-vasküler hastalıklar dünya genelinde en çok ölüme sebep olan hastalıklar arasında yer
almaktadır. Bir kardiyo-vasküler hastalık olan kalp yetmezliği, kalbin vücudun ihtiyaç duyduğu kanı
pompalayamaması durumudur. Ülkemizde sıklıkla görülen bu hastalığın sonucu olarak ölümler
yaşanmaktadır. Bu çalışmada kalp yetmezliğe sahip hastaların sağ kalım veya ölüm durumlarının tahmin
edilmesi için makine öğrenmesi tabanlı bir yaklaşım önerilmektedir. Üç farklı sınıflandırma algoritması
kullanılarak önerilen yöntemin etkinliği değerlendirilmektedir. Gerçekleştirilen deneylerde, Yapay Sinir
Ağı algoritması ile en yüksek doğruluk değerine (86.67%) ulaşılmıştır. Önerilen yöntem, ölüm riskinin
yüksek olduğu kalp yetmezliği hastalarına daha etkin ve uygun tedavi planlarının hazırlanması açısından
yol gösterici olacaktır.