bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profiling of idiopathic macular hole vitreous proteome identifies the role of extracellular matrix remodelling, epithelial–mesenchymal transformation and unfolded protein-response pathways
Authors: Sen Sagnik , Udaya Prithviraj , Maheshwari Jayapal J , Ramasamy Kim , Kannan Naresh B , Dharmalingam Kuppamuthu 
Published: May 2023

Purpose:
To analyze and describe the proteome of the vitreous humour in eyes with idiopathic macular holes.

Methods:
We performed mass spectrometry (MS)-based label-free quantitative analysis of the vitreous proteome of idiopathic macular hole (IMH) and control donor vitreous. Comparative quantification was performed using SCAFFOLD software which calculated fold changes of differential expression. Bioinformatics analysis was performed using DAVID and STRING software.

Results:
A total of 448 proteins were identified by LC-MS/MS in IMH and cadaveric eye vitreous samples, of which 199 proteins were common. IMH samples had 189 proteins that were unique and 60 proteins were present only in the control cadaveric vitreous. We found upregulation of several extracellular matrix (ECM) and cytoskeletal proteins, namely collagen alpha-1 (XVIII) chain, N-cadherin, EFEMP1/fibulin-3, basement membrane-specific heparan sulfate proteoglycan core protein, and target of Nesh-3. Several cytoskeleton proteins, namely tubulin, actin, and fibronectin levels, were significantly lower in IMH vitreous, probably reflecting increased ECM degradation. IMH vitreous also had a downregulation of unfolded protein response-mediated-mediated apoptosis proteins, possibly related to a state of increased cell survival and proliferation, along with a remodelling and aberrant production of ECM contents.

Conclusion:
The pathogenesis of macular holes may involve ECM remodelling, epithelial–mesenchymal transformation, downregulation of apoptosis, protein folding defects, and complement pathway. The vitreo-retinal milieu in macular holes contain molecules related to both ECM degradation and inhibition of the same, thereby maintaining a homeostasis.
Cross-sectional study to describe the severity, bio-chemical associations, and final outcomes of COVID-19-associated rhino-orbital-cerebral mucormycosis in a tertiary hospital of East India
Authors: Kumari Abhilasha , Ranjan Alok , Nishant Prateek , Sinha Sony , Sinha Ranjeet K 
Published: May 2023

Purpose:
The second wave of coronavirus disease 2019 (COVID-19) pandemic triggered a mucormycosis epidemic in India. Diabetes mellitus and dysregulated immune response were contributors, and rhino-orbital-cerebral mucormycosis (ROCM) was the most common presentation. It is however not known whether bio-chemical parameters at presentation correlate with stage of ROCM or final outcome in terms of vision or mortality.

Methods:
This retrospective, hospital-based study included all in-patients of mucormycosis with ophthalmic manifestations at presentation admitted during June 1, 2021 to August 31, 2021. It aimed to evaluate the association between severity of infection, serum levels of HbA1c, ferritin, interleukin-6 (IL-6), C-reactive protein (CRP), and D-dimer levels at presentation and outcome.

Results:
There were altogether 47 eligible cases having a mean age of 48.8 ± 10.9 years with a male:female ratio of 2.6:1; forty-two (89.4%) had pre-existing diabetes, and five (10.6%) had steroid-induced hyperglycemia. The mean HbA1c among diabetics was 9.7 ± 2.1. HbA1c and serum CRP showed an increase over subsequent stages, which was not statistically significant (P = 0.31). IL-6 values for all stages were similar (P = 0.97). Only serum ferritin levels showed a statistically significant increase over stages (P = 0.04). IL-6 was significantly lower (P = 0.03) in patients who survived, whereas CRP levels were significantly lower in patients who had final visual acuity (VA) better than only perception of light (P = 0.03).

Conclusion:
Uncontrolled diabetes mellitus is a significant association of ROCM. Serum ferritin levels at presentation best correlate with extent of the disease. CRP levels are best to prognosticate cases that will have sufficient VA to carry on activities of daily living, whereas IL-6 levels are best associated with survival.
Higher-order aberrations and visual quality after incision lenticule extraction surgery with intraoperative angle kappa adjustments between small and large kappa patients: A 2-year follow-up
Authors: Xie Mengzhen , Deng Yingping , Sun Chengshu , Qiu Lemei , Tang Jing 
Published: May 2023

Purpose:
To evaluate the postoperative visual outcomes, that is, corneal higher-order aberrations (HOAs) and visual quality, of patients with an angle kappa greater than 0.30 mm who underwent angle kappa adjustment during small-incision lenticule extraction (SMILE) 2 years after surgery compared to eyes with an angle kappa less than 0.30 mm.

Methods:
This was a retrospective study and included 12 patients from October 2019 to December 2019 who underwent the SMILE procedure for correction of myopia and myopic astigmatism and had one eye with a large kappa angle and another eye with a small kappa angle. Twenty-four months after surgery, an optical quality analysis system (OQAS II; Visiometrics, Terrassa, Spain) was used to measure the modulation transfer function cutoff frequency (MTFcutoff), Strehl2D ratio, and objective scatter index (OSI). HOAs were measured with a Tracey iTrace Visual Function Analyzer (Tracey version 6.1.0; Tracey Technologies, Houston, TX, USA). Assessment of subjective visual quality was achieved using the quality of vision (QOV) questionnaire.

Results:
At 24 months postoperatively, the mean spherical equivalent (SE) refraction was − 0.32 ± 0.40 and − 0.31 ± 0.35 in the S-kappa group (kappa <0.3 mm) and the L-kappa group (kappa ≥0.3 mm), respectively (P > 0.05). The mean OSI was 0.73 ± 0.32 and 0.81 ± 0.47, respectively (P > 0.05). There was no significant difference in MTFcutoff and Strehl2D ratio between the two groups (P > 0.05). Total HOA, coma, spherical, trefoil, and secondary astigmatism were not significantly different (P > 0.05) between the two groups.

Conclusion:
Adjustment of angle kappa during SMILE helps reduce the decentration, results in less HOAs, and promotes visual quality. It provides a reliable method to optimize the treatment concentration in SMILE.
Radial peripapillary capillary network in optic disc anomalies with abnormal tissues on disc surface
Authors: Mansoori Tarannum 
Published: May 2023

Background:
Optic disc anomalies with abnormal tissue on the disc surface includes, myelinated nerve fiber, optic disc drusen, and Bergmeister papillae. Imaging the radial peripapillary capillary (RPC) network in optic disc anomalies with optical coherence tomography–angiography (OCTA) can give information on the RPC network in these conditions.

Purpose:
This video describes the OCTA of optic nerve head and RPC network using the angio disc mode in cases of optic disc anomalies with abnormal tissue on the disc surface.

Synopsis:
This video presents characteristic features of RPC network in one eye each of myelinated nerve fiber, optic disc drusen, and Bergmeister papillae.

Highlights:
OCTA in optic disc anomalies with abnormal tissue on the disc surface show a dense RPC microvascular network. OCTA is an effective imaging modality to study vascular plexus/RPC and their alteration in these disc anomalies.

Video link:
https://youtu.be/zlflgijy56c.

Key words: Optic disc anomalies, OCTA, RPC network
Role of Incontinence Severity Index in Evaluating Severity and Impact of Treatment Of Stress Urinary Incontinence
Authors: Sharma Jai Bhagwan , Kakkad Vivek , Roy K. K. , Kumari Rajesh , Pandey Kavita 
Published: May 2023

Background:
Stress urinary incontinence (SUI) is a common ailment in affecting quality of life. This study was performed to see role of incontinence severity index (ISI) in evaluating severity of SUI and to see the impact of treatment of SUI.

Materials and Methods:
A total of 40 women with the diagnosis of SUI on history and clinical examination were enrolled. ISI was calculated on all the women before treatment. All women were treated with either conservative treatment (pelvic floor exercises, life style modification, and duloxetine therapy) (4, 10%) or Burch's colposuspension (18, 45%) or tension-free obturator tape (18, 45%) as per clinical situation after discussion with patients. ISI was again calculated 6 months after treatment.

Results:
Mean age, parity, body mass index in the study were 41.60 years, 2.73, and 24.2 kg/m2, respectively. All 40 (100%) patients had SUI with the mean duration of symptoms being 4.04 years. A total of 11 (27.5%) had moderate SUI (ISI 3–6), while 24 (60%) had severe SUI (ISI 8–9), while 5 (12.5%) had very severe SUI (ISI 12). Range of pretreatment ISI was 3–12 with mean being 8.8 ± 3.2. Posttreatment ISI reduced significantly with range of 1–4 and mean of 1.3 ± 0.4 (P < 0.001). The reduction was significant for all the groups, but there was no significant difference in efficacy of three treatment groups. Statistical analysis was done using SPSS IBM Version 2-1-0 using Chi-square test, Fisher's Extract test, and ANOVA test as appropriate.

Conclusion:
ISI is a useful modality to evaluate the severity of SUI and to see the impact of treatment modalities on SUI.
Combination of B-Mode Ultrasound and Doppler Ultrasound in Approaching to Uterine Intracavitary Pathologies Among Women Above 40 Years with Abnormal Uterine Bleeding
Authors: Nguyen Phuc Nhon , Nguyen Van Tuan 
Published: May 2023

Objectives:
To determine the role of B-mode ultrasonography combined with Doppler ultrasonography in diagnosing uterine intracavitary pathology in perimenopausal and postmenopausal women with abnormal uterine bleeding (AUB).

Patients and Methods:
This prospective observational study included 150 women aged >40 years with AUB hospitalized at Hue University Hospital and Hue Central Hospital between 6/2016 and 6/2019. All participants were investigated by B-mode transvaginal ultrasound and Doppler transvaginal ultrasound, and the result of sonography was compared to the histopathological endpoint.

Results:
The morphological features, structure, margin, border line of the endometrial-mass lesion, intracavitary uterine fluid, and Doppler signal clearly differed between benign and malignant intracavitary pathologies (P < 0.0001). However, echogenicity had a limited value in distinguishing between uterine intracavitary pathologies (P = 0.1). The sensitivity and specificity of the pedicle sign in diagnosing endometrial polyps were 50.0% and 97.6%, respectively; for the circular pattern in subendometrial fibroids were 46.2% and 100.0%, respectively; for the multiple vessel pattern in endometrial cancer were 64.0% and 96.0%, respectively, and for the scattered-vessel pattern in endometrial hyperplasia were 43.96% and 56.43%, respectively.

Conclusions:
Ultrasound B-mode combined with Doppler as a noninvasive tool was significantly valuable in the diagnostic procedures for uterine intracavitary pathology in perimenopausal and postmenopausal women with AUB. It could also help differentiate malignant diseases from benign endometrial changes.
Use of artificial intelligence in forecasting glaucoma progression
Authors: Thakur Sahil , Dinh Linh Le , Lavanya Raghavan , Quek Ten Cheer , Liu Yong , Cheng Ching-Yu 
Published: May 2023

Abstract
Artificial intelligence (AI) has been widely used in ophthalmology for disease detection and monitoring progression. For glaucoma research, AI has been used to understand progression patterns and forecast disease trajectory based on analysis of clinical and imaging data. Techniques such as machine learning, natural language processing, and deep learning have been employed for this purpose. The results from studies using AI for forecasting glaucoma progression however vary considerably due to dataset constraints, lack of a standard progression definition and differences in methodology and approach. While glaucoma detection and screening have been the focus of most research that has been published in the last few years, in this narrative review we focus on studies that specifically address glaucoma progression. We also summarize the current evidence, highlight studies that have translational potential, and provide suggestions on how future research that addresses glaucoma progression can be improved.
Spectral characteristics of Schrödinger operators generated by product systems
Authors: Damanik David , Fillman Jake , Gohlke Philipp 
Published: May 2023

Motivated by the question of what spectral properties of dynamically defined Schrödinger operators may be preserved under periodic perturbations, we study ergodic Schrödinger operators defined over product dynamical systems in which one factor is periodic and the other factor is either a subshift over a finite alphabet or an irrational rotation of the circle. The scenario given by a periodic background potential corresponds to a separable structure in which the sampling function is the sum of two pieces, each of which depends only on a single factor of the product system. However, in each case that we study, our methods apply more generally to sampling functions that allow non-trivial dependencies between the product factors.
In the case in which one factor is a Boshernitzan subshift, we prove that either the resulting operators are periodic or the resulting spectra must be Cantor sets. The main ingredient is a suitable stability result for the Boshernitzan condition under taking products. We also discuss the stability of purely singular continuous spectrum, which, given the zero-measure spectrum result, amounts to stability results for eigenvalue exclusion. In particular, we examine situations in which the existing criteria for the exclusion of eigenvalues are stable under periodic perturbations. As a highlight of this, we show that any simple Toeplitz subshift over a binary alphabet exhibits uniform absence of eigenvalues on the hull for any periodic perturbation whose period is commensurate with the coding sequence. This is new, even in the case in which the periodic background vanishes entirely. In the case of a full shift, we give an effective criterion to compute exactly the spectrum of a random Anderson model perturbed by a potential of period two, and we further show that the naive generalization of this criterion does not hold for period three. Next, we consider quasi-periodic potentials with potentials generated by trigonometric polynomials with periodic background. We show that the quasiperiodic cocycle induced by passing to blocks of period length is subcritical when the coupling constant is small and supercritical when the coupling constant is large. Thus, the spectral type is absolutely continuous for small coupling and pure point (for a.e. frequency and phase) when the coupling is large.
PENGARUH KEBIJAKAN HARGA DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN SABUN MEREK LIFEBUOY PADA PT. MITRA ANDAL SEJATI MEDAN
Authors: Laia David Walterus , Napitupulu R.B. , Simatupang Sabar L.T. 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui secara parsial dan secara simultan Pengaruh Kebijakan Harga dan Kualitas Produk terhadap Keputusan Pembelian Sabun Merek Lifebuoy pada PT. Mitra Andal Sejati Medan. Penelitian ini menggunakkan metode deskriptif dengan pendekatan kuantitatif, dengan teknik pengambilan sampel menggunakan metode Accidental sampling (sampling peluang). Jumlah sampel dalam penelitian ini adalah 150 orang responden yang telah melakukan pembelian sabun merek lifebuoy pada PT. Mitra Andal Sejati Medan. Kemudian, dalam analisis data penelitian menggunakan statistical product and service solution (SPSS) versi 25.0 dan Microsoft Excel 2007. Hasil Koefisien determinasi penelitian ini menunjukkan bahwa Kebijakan Harga dan Kualitas Produk terhadap Keputusan Pembelian dengan nilai R sebesar 92,4% dan nilai R square sebesar 85,3% artinya memiliki hubungan sangat kuat. Kemudian, secara parsial Kebijakan Harga terhadap Keputusan Pembelian thitung > ttabel (5,601 > 1,976) pada taraf signifikan 0,000 < 0,05, dan Kualitas Produk Terhadap terhadap Keputusan Pembelian thitung < ttabel (4,935 < 1,976) pada taraf signifikan 0,000 < 0,05 kemudian secara simultan Kebijakan Harga dan Kualitas Produk terhadap Keputusan Pembelian sebesar Fhitung 431,801 > Ftabel 3,060 Dengan hasil tersebut, secara simultan Kebijakan Harga dan Kualitas Produk berpengaruh positif dan signifikan terhadap Keputusan Pembelian Sabun Merek Lifebuoy pada PT. Mitra Andal Sejati Medan. Secara parsial Kebijakan Harga berpengaruh positif dan signifikan terhadap Keputusan Pembelian, dan serta secara parsial kualitas produk menunjukkan pengaruh positif dan signifikan terhadap Keputusan Pembelian sabun Merek Lifebuoy pada PT. Mitra Andal Sejati Medan.
PENGARUH ETIKA KERJA DAN BUDAYA KERJA TERHADAP PRESTASI KERJA KARYAWANPADA PERUM BULOG KANTOR CABANG MEDAN
Authors: Hasugian Edi Arianto , Pandiangan Poppi Natalia , Tarigan Jenni , Hutabarat Lamminar 
Published: May 2023

Dengan meningkatkan kualitas sumber daya manusia dalam perusahaan diharapkan dapat meningkatkan prestasi kerja, karena prestasi kerja sangat penting bagi perusahaan yang merupakan indikator utama seberapa baik kinerja perusahaan. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh etika kerja dan budaya kerja terhadap prestasi kerja karyawan pada Perum Bulog Kantor Cabang Medan. Sampel yang digunakan berjumlah 32 responden. Penelitian ini menggunakan metode kuantitatif dengan teknik pengumpulan data melalui penyebaran kuesioner. Teknik analisis data yang digunakan adalah analisis regresi linear berganda menggunakan program SPSS Versi 22. Hasil penelitian menunjukkan bahwa persamaan regresi Y = 6,473 + 0,323X1 + 0,502X2. Etika Kerja berpengaruh positif dan signifikan terhadap prestasi kerja. Hasil diketahui berdasarkan nilai (thitung 4,358>ttabel 2,045) dengan nilai signifikansi (0,000<0,05). Budaya kerja berpengaruh positif dan signifikan terhadap prestasi kerja. Hasil diketahui berdasarkan nilai (thitung 5,273>ttabel 2,045) dengan nilai signifikansi (0,000<0,05). Etika Kerja dan Budaya Kerja berpengaruh signifikan terhadap prestasi kerja. Hasil diketahui dari nilai (Fhitung 43,485>Ftabel 3,33) dengan nilai signifikansi (0,000<0,05). Koefisien Determinasi Adjusted R Square sebesar 0,733 artinya sebesar 73,3% Prestasi kerja karyawan Perum Bulog Kantor Cabang Medan dipengaruhi oleh variasi Etika Kerja dan Budaya Kerja.
PENGARUH MOTIVASI DAN PELATIHAN TERHADAP PRESTASI KERJA KARYAWAN PADA PT. CAREFASTINDO MEDAN
Authors: Laia Odima Darmawati , Halawa Morli , Taringan Jenni , Simatupang Sabar L.T 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh Motivasi dan Pelatihan terhadap Prestasi Kerja Karyawan secara simultan. Jenis penelitian yang digunakan adalah penelitan penjelasan (explanatory research) dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah sejumlah karyawan PT. Carefastindo Medan. Sampel berjumlah 50 responden dan teknik pengumpulan data dalam penelitian ini adalah daftar pertanyaan (Quesioner) dan wawancara. Teknik analisis menggunakan uji asumsi klasik, regresi berganda dan uji hipotesis. Hasil regresi linier berganda diperoleh nilai Y = 3,452 + 0,372X1 + 0,676X2. Berdasarkan Hasil Uji t parsial diperoleh nilai thitung>ttabel untuk Motivasi (X1) = 4,482>2,011 dan Pelatihan (X2) = 10,024>2,011 dengan tingkat signifikansi 0,000<0,05, hal ini menunjukkan bahwa Motivasi dan Pelatihan secara parsial berpengaruh signifikan terhadap Prestasi Kerja Karyawan. Hasil F hitung sebesar 151,580 > nilai F-tabel 3.19, sedangkan nilai koefisien determinasi (R2) diketahui nilai R Square yang diperoleh adalah sebesar 0,866 (86,6%), Sedangkan sisanya sebesar 13,4 % dipengaruhi oleh variabel lain yang tidak diteliti, seperti merek, harga, produk dan lain-lain. Berdasarkan hasil dari penelitian ini, maka dapat disimpulkan bahwa Motivasi dan Pelatihan secara simultan berpengaruh signifikan terhadap Prestasi Kerja Karyawan pada PT. carefastindo Medan. Disarankan agar perusahaan lebih meningkatkan Motivasi bagi karyawan serta pelatihan yang baik dalam perusahaan agar tecapainya prestasiKerja Karyawan.
Revisiting the formation of universal competencies of foreign students
Authors: Spichak Nikolay Grigorievich , Fedorova Irina Valerievna 
Published: May 2023

Foreign citizens study at Russian universities according to educational programs in accordance with the Federal State Educational Standard, designed for pre-university training of Russian citizens. This is especially evident in the formation of universal competencies (UC). The identification and search for the solution to the problems that arise in this case determine the relevance of the research. We set a goal to determine how significant the differences were between the content of pre-university Russian and foreign education, which is necessary for the formation of UC-11 – citizenship and UC-9 associated with it – inclusive culture, using the method of comparative analysis. Documents on foreign education served as the material.When developing an educational program in terms of the formation of UC-11, universities take into account continuity with the general educational subject of social science, which Russian students study at a basic or advanced level. In this regard, the content of foreign education was assessed from the standpoint of the presence of the disciplines of the subject area «Social sciences». The analysis carried out showed their complete or partial absence in pre-university foreign education. Meanwhile, it turned out that the inclusive position of many foreign students, unlike Russian students, was practically formed. Thus, the university needs to develop individual educational programs for foreign students, providing for the expansion of the list of variable and optional disciplines, changing the ratio of contact work with a teacher and student’s independent work. The optimal form remains the previous or parallel development of a specially designed additional educational program.
Training professional skills using the Latin language (the case of medical specialties)
Authors: Bibikova Elvira Vitalievna 
Published: May 2023

The relevance of the research is due to the fact that the study of the Latin language in a medical university has a purely professional orientation. The main goal of mastering this discipline is to train competent specialists to be proficient in professional terminology. Within the framework of this research, an attempt has been made to demonstrate the possibilities of the Latin language in teaching professional skills of future doctors and pharmacists. The article discusses three subsystems of medical terminology: anatomical-histological, clinical and pharmaceutical ones. As for the anatomical and histological section, typical mistakes and difficulties faced by students have been analyzed, and examples of tasks used by the author to solve these problems given. In the clinical section, the emphasis is made on the tasks that allow you to create an atmosphere of professional activity in the classroom and bring it closer to practical activity. The development of the pharmaceutical section is aimed at forming the terminological competence of future medical workers in the field of pharmaceutical terminology and general formulation. The author gives a brief overview of the material studied at this stage, and gives examples of practical tasks for its better assimilation. All the materials and exercises described in the article are used by the author in the process of teaching Latin in a medical university. Empirical methods, methods of comparison and analysis have been used in the research.As a result, it has been shown that successful teaching professional skills at a medical university is largely possible due to the study of the Latin language.