bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical study on the relation between seismic source parameters and the occurrence of coal bursts due to pillar failure
Authors: Jia Jinhe 
Published: January 2023

Abstract
Numerical tests using the seismic analysis method are conducted to investigate the occurrence of coal bursts due to pillar failure, which is represented by a shear fracture in the pillar’s elastic core area. The assumption is that the fracture development process is the key factor affecting the occurrence of coal bursts and coal burst damages. Three fracturing patterns are offered to simulate different development processes of the same fracture with the given original and final mechanical properties and the given fracturing time. A series of slip movements occur between two sides of the fracture during the fracture development process and cause seismic events. The seismic source parameters, including peak velocity and duration of slip velocity pulses, moment factor and moment intensity factor, are employed to characterize the seismic events. Data are obtained to investigate the relation between seismic source parameters and the occurrence of coal bursts or the coal burst damages. The results show the fracture development process has a great influence on the coal burst damages; the moment intensity factor is a qualified seismic source characteristic parameter for determining the occurrence of coal bursts, and can distinguish not only between burst cases and non-burst cases, but also between slight burst cases and moderate burst cases; moment factor is not a qualified seismic source characteristic parameter for determining the occurrence of coal bursts, though seismic moment is generally regarded as the strength of seismic events.
Investigating the Effects of Climate Change on Precipitation over Eastern Iran under CMIP6 Scenarios
Authors: Imanipour Hossain , Karami Mokhtar 
Published: January 2023

Abstract
Global climate change has caused numerous concerns about its harmful effects on natural and human systems. One of the obvious effects of global warming is the change amount of precipitation. The present study aims to investigate the effects of future climate changes on the precipitation situation in eastern Iran using the precipitation combination of eight Atmosphere-Ocean General Circulation Models (AOGCMs) from the -Coupled Model Intercomparison Project Phase 6 (CMIP6) and the zoning of precipitation values for the baseline period (1988–2020), the near-future period 2021–2053, and the far-future period 2054–2086 under three scenarios SSP1_2.6, SSP2_4.5, and SSP5_8.5 in the study area. Initially, to verify and rank the models, the results of statistical measures, root-mean-square error (RMSE), explanatory coefficient, standard deviation (SD), and the Kling-Gupta efficiency (KGE) were employed to compare the results of historical period data of models and observational data of the selected stations. After ensuring the ability of all eight models in simulating precipitation to reduce uncertainty, the results of all eight models were combined using Chen's weighting method, and the weight value of each model was obtained month by month for the stations of the study area. Finally, analyzing the obtained results showed that the amount of precipitation has decreased in summers and winters, while it has increased in springs and autumns slightly. But the annual precipitation in all scenarios of the future period shows lower figures than the observation period. This is a warning for the environment and agricultural affairs and all aspects that require greater vigilance from managers and planners to adapt to the reduction of precipitation, address the destructive effects of climate change, and prevent economic problems in the study area.
MiR-651-3p/CAV1/EGFR axis Modulates Progression and Vasculogenic Mimicry in Triple-negative Breast Cancer
Authors: Hai Linyue , Zhao Jingjing , Cao Xuchen , Xiao Chunhua 
Published: January 2023

Abstract
Background: Breast cancer (BC) has become the most common type of cancer and the second most common cause of cancer-related death. In comparison with other subtypes of breast cancer, triple-negative breast cancer (TNBC) is highly aggressive, more likely to metastasize, and has a shorter survival time. MiRNAs play an inhibitory or promoting role in cancer, and are involved in several cell signaling pathways, including growth, proliferation, differentiation, and survival. Vasculogenic mimicry (VM) is associated with invasive disease, tumor spread, metastasis, and poor prognosis. Additional research is needed to determine the mechanisms governing VM formation in TNBC.
Methods: We measured RNA and protein expression using quantitative real-time PCR (RT-qPCR) and western blotting. Assays assessing cell proliferation were conducted with CCK-8, cell cycle, and colony formation. Cell migration and invasion were evaluated using transwells, scratch tests, and high-intensity imaging. Luciferase reporter assays were used to confirm miR-651-3p and CAV1 target relationships.
Results: In TNBC, miR-651-3p was significantly overexpressed, implicating it as an oncogene. By inhibiting CAV1 transcriptional synthesis, miR-651-3p can enhance the activity of EGFR pathways, leading to promotion of TNBC proliferation, VM formation, and migration.
Conclusion: It was determined that miR-651-3p/CAV1/EGFR axis could be a therapeutic target for TNBC in this study.
Decadal changes in global oceanic primary productivity and key drivers
Authors: Maishal Subhadeep 
Published: January 2023

Abstract
Ocean phytoplankton form complex groups of interplayed living organisms in the marine food web, with profound control in marine biological and geochemical cycles, forming ecological structures and affecting climate regulatory systems. They have a significant impact on the marine biochemical and geochemical cycles, help to construct ecological structures, and influence the mechanisms that regulate the global climate. The world's oceanic regions are changing very rapidly there Physical processes and biogeochemistry. A significant portion of the global population relies on ocean resources for their daily livelihood. Since the biogeochemistry of the oceans is crucial for the marine food chain. It is imperative to monitor and detect the changes in oceans' Primary Productivity (PP). Rates and drivers of Primary Productivity (PP) have been well understood for many terrestrial diversified ecosystems but persist unsolved for many marine ecosystems, particularly those within open ocean environments. Here, we analyze the decadal changes in Net Primary Productivity (NPP) in the global ocean and their potential drivers. Ocean warming strengthens upper ocean seasonal or inter-seasonal thermal stratification, mesoscale circulation, water density, and nutrient uptake. These are the major factors playing central roles in regulating PP all over the ocean.
Incidence, severity and reversibility of acute kidney injury after elective hip and knee arthroplasty in patients receiving celecoxib perioperatively as one of the standard multimodal analgesic protocols
Authors: Chan Manson Tak Hei , Chan Timmy Chi Wing , Mak Henry Chi Yeung , Chan Will Shing Him , Wong Stanley Sau Ching , Wong Vincent Kai Chung , Chan Lewis Ping Keung , Cheung Chi Wai 
Published: January 2023

Abstract
Background Acute kidney injury (AKI) may complicate up to 10% of primary lower-extremity total joint arthroplasties. However, none of these previous studies evaluated the duration and reversibility of AKI. Moreover, none specifically evaluated the impact of perioperative celecoxib on the incidence and severity of AKI, especially for patients with preexisting renal impairment.
The aim of this study was to retrospectively review the incidence, severity and duration of AKI with short term perioperative celecoxib. We also aimed to evaluate the impact of perioperative celecoxib on the incidence and severity of AKI in patients with and without preexisting renal impairment.
Methods We retrospectively reviewed 1077 patients at Queen Mary Hospital, Hong Kong, from January 2018 to December 2021. Data were retrieved from the computerized medical records system.
Results One hundred of 1077 patients (9.3%) had postoperative AKI. Eight hundred eighty-eight patients (82.5%) were prescribed perioperative celecoxib, while 189 patients (17.5%) were not.
The overall incidence of AKI in those taking perioperative celecoxib was 9.2%, while it was 9.5% in those not taking perioperative celecoxib. There was no statistically significant difference. There was no association between perioperative celecoxib and postoperative AKI.
Among those who received perioperative celecoxib, the overall incidence of postoperative AKI in those with and without preexisting renal impairment was 9.3% and 9.2%, respectively. This was not statistically significant. The duration of AKI was 4 days for both groups. In both groups, most AKI cases were stage 1.
Conclusions Short term perioperative celecoxib probably had no additional AKI risk even in patients with preexisting renal impairment. Trial Registration ClinicalTrials.gov registration number NCT05595694.
Trial Registration
ClinicalTrials.gov registration number NCT05595694
RNA-Sequencing Predicts a Role of Androgen Receptor and Aldehyde Dehydrogenase 1A1 in Osteosarcoma Lung Metastases
Authors: Heim Tanya , Hankins Margaret , Belayneh Rebekah , Douglas Nerone , Dinh Vu , Kovvur Murali , Boone David , Ukani Vrutika , Bhogal Sumail , Patel Vaidehi , Moniz Taylor , Bailey Kelly , John Ivy , Schoedel Karen , Weiss Kurt , Watters Rebecca 
Published: January 2023

Abstract
One-third of pediatric patients with osteosarcoma (OS) develop lung metastases (LM), which is the primary predictor of mortality. While current treatments of patients with localized bone disease have been successful in producing 5-year survival rates of 65–70%, patients with LM experience poor survival rates of only 19–30%. Unacceptably, this situation that has remained unchanged for 30 years. Thus, there is an urgent need to elucidate the mechanisms of metastatic spread in OS and to identify targetable molecular pathways that enable more effective treatments for patients with LM. We aimed to identify OS-specific gene alterations using RNA-sequencing with a focus on those corresponding with LM in a genetic comparison of primary and metastatic human tissues. Samples of primary and metastatic tumors, including 4 matched sets, were obtained from patients with OS. Our data demonstrate upstream regulation of the androgen receptor (AR) pathway in LM and predicts aldehyde dehydrogenase 1A1 (ALDH1A1) as an upstream regulator. Identification of AR pathway upregulation in human LM tissue samples may provide a target for novel therapeutics for patients with LM resistant to conventional chemotherapy.
Negative impact of the microvascular area to tumor area ratio on the response to EGFR-TKI in NSCLC with EGFR mutation
Authors: Anai Moriyasu , Saruwatari Koichi , Imamura Kosuke , Fujino Kosuke , Jodai Takayuki , Sakata Shinya , Iyama Shinji , Tomita Yusuke , Saeki Sho , Ichiyasu Hidenori , Ikeda Koei , Suzuki Minoru , Sakagami Takuro 
Published: January 2023

Abstract
The aim of this study was to investigate whether a tumor microenvironment, abundant in microvessels, affects epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR-TKI) efficacy in patients with non-small cell lung cancer (NSCLC) and EGFR mutations. We retrospectively studied the data of 40 post-operative patients with recurrent NSCLC and EGFRmutations who received EGFR-TKIs as a first-line treatment at Kumamoto University Hospital between January 2010 and February 2021. Tumor sections were retrieved from the tissue registry and analyzed for CD34-positive microvessels using immunohistochemical techniques. The microvascular area ratio (MVR), which is the CD34-positive microvascular area compared to the total tumor area, was measured using StrataQuest. The predictive value of MVR on treatment outcome, assessed via progression-free survival (PFS), was evaluated using a multivariate Cox proportional hazard model. The median PFS in the high MVR group (≥0.058) was significantly shorter than that in the low MVR group (<0.058; 296 d [95% confidence interval [CI]: 217–374 d] vs. 918 d [95% CI: 279–1556 d], P=0.002). Multivariate analysis revealed that high MVR was an independent negative predictor of PFS (hazard ratio, 3.21 [95% CI: 1.18–8.76], P=0.022). High MVR may critically affect EGFR-TKI resistance in patients with NSCLC and EGFR mutations.
Piecewise Congruence Regressed Indexive Extreme Learning classifier for Software Fault Prediction
Authors: S Sureka , P Venkatesh 
Published: January 2023

Abstract
Early detection of software faults is significant task in the software development process. With the development of defect prediction technology, software with defects negatively impacts on operational costs and finally affects client satisfaction. Therefore, early defect prediction by the project managers is critical and challenging task. Different approaches were developed to predict software faults. However two essential factors are major issues such as timely and accurate detection. Therefore, a novel technique is required for accurate and timely software fault production. In this paper, a Piecewise Congruence Regressed Indexive Extreme Learning Classifier (PRILEC) is introduced for accurate software fault prediction with minimum time. The PRILEC technique consists of two major processes namely feature selection or software metric selection from the input dataset and the classification. In the first process, feature selection or software metric selection process is carried out by using congruence correlative piecewise regression. First, the numbers of features or metrics are collected from the dataset. Then the correlation between the features is measured using congruence coefficient and identifies the more relevant features. With the selected features, the classification is performed by applying statistical indexive levenberg extreme learning classifier for fault prediction with higher accuracy. In the extreme learning classifier, the testing and raining data analysis is performed with the help of Camargo's statistical index. Then the Hardlimit activation function is applied to identify the defective or non-defective software code. Finally, the Levenberg–Marquardt algorithm is applied to minimize the least square problem and obtain the final better classification results at output layer. In this way, software fault prediction is carried out with higher accuracy and minimum time. Experimental assessment of the proposed technique is carried out with respect to fault prediction accuracy, precision, recall, F-measure, prediction, specificity and time complexity with a different number of data. The quantitatively discussed results indicate that the performance of proposed technique increases data accuracy of software fault prediction with a higher minimum time as well as space complexity than the conventional method.
The aftereffects of mass dismissals and detentions of academics at Turkish universities
Authors: Hosoglu Salih , Aktürk Zekeriya 
Published: January 2023

Abstract
The number of scientific publications is an essential objective indicator of the scientific level of countries. After 2016, the academic reputation of Turkey declined in the rankings steadily despite significant investments in higher education. Between 2016 and 2018, more than eight thousand academics were dismissed from state universities, corresponding to 5.7% (n = 3 542) of the 60 385 academics. This study evaluated the effects of these mass dismissals on scientific publication performance. We assessed all 108 state universities’ scientific publication performances in 2016. The universities were categorized according to the dismissal levels compared to the number of academics in 2016 as < 5% (n = 47, Group 1), 5–10% (n = 41, Group 2), and > 10% (n = 20, Group 3). The performed and expected annual scientific publications were compared after the mass purge. The publications increased approximately 13.2% per year between 2012 and 2016 (from 34 130 to 52 168) and 3.1% from 2016 to 2019 (from 52 168 to 57 013). The expected total numbers of publications were calculated as 55 643 for 2017, 60 225 for 2018, and 64 806 for 2019; the observed-expected differences were 13.8%, 13.4%, and 12.0%, respectively. The mean number of publications decreased in 2017 in all three groups. Group 2 and Group 3 were more affected than Group 1. Significant differences were shown between Group 1 and Group 3 (p for 2017, 2018, and 2019, 0.027, 0.009, and 0.017, respectively). The academic purge at Turkish universities showed a significant impact on overall academic productivity beyond the number of academics dismissed.
First isolation of the terbinafine- and itraconazole-resistant Trichophyton indotineae in China
Authors: Kong Xue , Mei Huan , Zheng Hailin , Song Ge , Tang Chao , De Hoog Sybren , Li Xiaofang , She Xiaodong , Liu Weida , Liang Guanzhao 
Published: January 2023

Abstract
Background

Trichophyton indotineae, a new species of dermatophytes, has become a significant concern in treating dermatophytosis due to the high level of terbinafine resistance reported in India and even worldwide.

Objectives

We aimed to report the first case of the terbinafine- and itraconazole-resistant T. indotineae in China, by identifying the phylogenetic classification of the isolate strain, and detecting the drug resistance, gene mutation and expression.

Patients/Methods:

The skin scales of patient were cultured on SDA and authenticated by DNA sequencing and MALDI-TOF MS. Antifungal susceptibility to itraconazole,terbinafine et al was tested following the M38-A2 CLSI protocol to examine MIC. The isolate was screened for mutations in the squalene epoxidase (SQLE) gene by Sanger sequencing and detected the expression of CYP51A and CYP51B by qRT-PCR.

Results

We isolated the first multi-resistant ITS genotype VIII sibling of the T. mentagrophytes complex (T. indotineae) in China. The strain harbored high terbinafine MICs (>32 µg/mL) and had a mutation in the squalene epoxidase gene with amino acid substitution (Phe397Leu, mutation 1191C > A). In addition, overexpression of CYP51A and CYP51B was observed. With multiple relapses, the patient finally achieved clinical cure by itraconazole pulse therapy and topical clotrimazole cream for 5 weeks.

Conclusions

We reported the first indigenous case of T. indotineae in China, indicating the intensification of drug resistance in dermatophytes. Besides, we found longtime itraconazole pulse therapy (0.2g p. o. BID) may provide a practical reference for clinicians in treating refractory dermatophytes.
Optimal Drug Dosing to Prevent Chemotherapy Induced Neutropenia
Authors: Radisavljevic-Gajic Verica , Karagiannis Dimitrios 
Published: January 2023

Abstract
In the first part of this paper, we have considered the well-known myelosuppression mathematical model of Lena Friberg and her coworkers from the system analysis point of view. We have studied the linearized model at steady state and considered its stability, controllability, observability, and scaling of model variables. It was noticed that the linearized dynamics of two state variables is slow (corresponding to the numbers of maturing cells in the third compartment and the number of circulating cells) and that three remaining state variables display fast dynamics (corresponding to the number of proliferative cells and the number of maturing cells in the first and second compartments). In order to avoid numerical computations with large numbers scaling of system state variables by a factor of \({10^9}\) has been utilized. An interesting and important result regarding a dosing strategy has been obtained by simulating dynamics of the considered nonlinear system and observing the steady state value for the number of circulating neutrophil cells. In the second part of the paper, a method was proposed for optimal chemotherapy dosing using a result from optimal control theory in order to reduce the amount of administrated chemotherapy drugs and to keep the number of neutrophil cells above a pre-specified desired ANC (actual neutrophil count) level. It was shown that in the case of continuous dosing, the variable optimal amounts of the drug have to be administrated daily based on information regarding the actual count of neutrophils. This result mathematically establishes that administrating constant amount of drugs daily cannot provide the optimal dosing schedule. In general, the obtained results open a door for modern personalized and optimized medicine that requires daily monitoring of fundamental variables and daily drug administration in variable quantities based on the actual state of the patient’s fundamental variables (parameters) for the considered decease.
Calculation of the Cosmological Constant for Fermion and Boson Electric Charges Swap Lie-Groupoid
Authors: Koorambas Elias 
Published: January 2023

Abstract
Following a previous article [1], in this paper, we investigate a version of the Standard Model (SM) algebroid with the anchor map depending on the Electric Charge Swap (ECS) angle θs. We find that many SM algebras depend on θs. We call these ECSM algebras. Furthermore, the SM algebroid is integrable to the SM groupoid; our results, therefore, potentially extend well beyond this case. We then investigate how the massive ECS particle can be derived from the breaking of the symmetry of the SM groupoid. We find that the ECS particle mass is related to the SM particle mass through the ECS angle θs. We investigate the finite subgroups of the ECS Möbius transformations. The ECS angle qs could originate from the ECS dihedral group that refers to the symmetry of the Particle polygon (P-gon). This angle can then be determined through the multi-triangulation of a convex-particle P-gon. Finally, we find that, at loop-level, the ECS Physics is different from the SM physics, and the ECSM mass is suppressed by the particle Catalan numbers CP. For 24-fermions [1], and 6-vector gauge bosons, the calculated one-loop radiative correction to the bare cosmological constant Λ0 is 10-47GeV4—very close to the experimental value.
PACS numbers: 02.20.-a, 11.25.Uv