bluuebunny/crossref_metadata_2025_split huggingface dataset:
PBP‐based bioprinting of hydrogels for biomedical applications
Authors: Jia Yongliang , Liu Junyu , Tan Ziwei , Luo Dongmei , Fu Xinyu , Hou Ruxia , Li Peiwen , Chen Yurou , Wang Xiangyu 
Published: April 2023

AbstractThree‐dimensional (3D) printing of hydrogels to form complex structures has been widely used in tissue engineering. Projection‐based 3D printing (PBP) has faster printing, lower cell damage, and higher printing resolution compared with other 3D printing methods, providing a potential strategy for printing elaborate 3D hydrogel structures. In this review, we introduced the composition and printing process of PBP. We then discuss the study of hydrogels for PBP, including chemical structure modification and property optimization. More importantly, we highlight the potential applications of PBP‐based hydrogels in regenerative medicine and tissue engineering, and discuss the current challenges and future prospects of PBP‐based hydrogels. Ideas are provided for the study of PBP, hydrogel bioinks, and related fields.
Hierarchical biopolymer‐based materials and composites
Authors: Fredricks Jeremy L. , Jimenez Andrew M. , Grandgeorge Paul , Meidl Rachel , Law Esther , Fan Jiadi , Roumeli Eleftheria 
Published: April 2023

AbstractThe mass production and disposal of non‐degradable fossil‐based plastics is responsible for alarming environmental and social issues when not managed responsibly. Towards manufacturing environmentally‐friendly materials,biopolymers, that is, polymers synthesized by living organisms, emerge as promising sustainable alternatives as they combine attractive mechanical properties, compostability, and renewable sourcing. In this review, we analyze the structural and mechanical properties of three of the most studied biopolymer classes: cellulose, chitin, and protein beta‐sheet structures. We first discuss the hierarchical structure of the biopolymers and how their rich interaction networks induce appealing mechanical properties. Then, we review different fabrication and processing methods to translate these attractive properties into macroscopic materials and composites. Finally, we discuss a nascent approach, which leverages the direct use of microorganisms, in the form of intact cells, tissues or dissociated biological matter (biomatter), as meso‐scale material building blocks. These non‐ or little pre‐processed biomatter building blocks are composed of the biopolymer structural elements (molecular‐nano scale), but also inherit the higher‐scale hierarchical characteristics. Processing‐structure–property relationships for biomatter‐based materials are discussed, emphasizing on the role of hierarchical arrangement, processing‐induced transformations, and intermolecular bonding, on the macroscopic mechanical properties. Finally, we present a perspective on the role of biopolymers in a circular economy.
Finite‐time exponentially extended dissipative filtering for singular time‐delay Markov jump systems with quantized outputs based on hidden Markov mode
Authors: Zhao Yong , Wu Bingyu , Zhang Weihai 
Published: April 2023

AbstractThis article investigates finite‐time exponentially extended dissipative filtering for singular Markov jump systems with time‐varying delays and quantized outputs. The filter and quantizer are both mode‐dependent and their modes are asynchronous with the system modes, which are described by hidden Markov model. A more general performance index named as finite‐time exponentially extended dissipativity is employed to make the concept of extended dissipativity in infinite‐time domain suitable for the finite‐time case. With the aid of a series of novel and effective schemes, sufficient conditions are established to guarantee that the filtering error dynamics are finite‐time stochastically bounded with the exponentially extended dissipative performance. An asynchronous filter is successfully designed by solving a set of linear matrices inequalities. Finally, numerical examples are given to demonstrate the effectiveness of proposed methods.
A coping model for school psychological counsellors: A qualitative study
Authors: Kılıç Memur Hale Nur , Sezgin Osman 
Published: April 2023

AbstractThis study analyzed the coping processes of psychological counsellors working in high schools in Turkey in the face of the challenges experienced in counselling sessions. The study used a qualitative research design: grounded theory. Semistructured interviews conducted with 33 high school counsellors were analyzed following Strauss and Corbin's analysis guidelines to create a coping model. The core category in the model was ‘coping’ while ‘actions/reactions’ explained what counsellors do to cope. Finally, ‘environmental factors’ and ‘personal factors’ influenced their coping processes. The findings are discussed in light of the existing literature to provide suggestions for school counsellors to develop self‐care/coping strategies, increase their resilience and decrease their burnout.
Exploring the relationships between Industry 4.0 implementation factors through systems thinking and network analysis
Authors: Hoyer Christian , Gunawan Indra , Reaiche Carmen Haule 
Published: April 2023

AbstractIndustry 4.0 provides companies with the technological and theoretical means to enhance data‐driven decision‐making procedures. To facilitate the transformation process, several studies have identified factors that need to be considered when implementing Industry 4.0 on a broader level. However, the dynamic relationship between these factors has yet to be understood to provide companies with the in‐depth knowledge needed to effectively manage the transition. The principal aim of our research is therefore to map out the complex relationships between the identified factors, by adapting a novel approach that combines network analysis and causal loop diagrams. Results show that the roles of implementation factors are not static, and what role they play depends on their position in the network, complementing the findings of previous investigations about the drivers of change. Furthermore, our findings indicate that multiple intervention points exist, shedding more light on how to develop effective implementation strategies.
Direct gas heating in linear concentrating solar collectors for power and industrial process heat production: Applications and challenges
Authors: Lecuona‐Neumann Antonio , Famiglietti Antonio 
Published: April 2023

AbstractParabolic trough collectors and linear Fresnel collectors are mature technologies for power production, and they are being recently applied to provide solar heat for industrial needs. Conventionally, they use a liquid as heat transfer fluid, either thermal oil or water, to carry heat from the receivers up to the point of conversion or delivery. Although liquids offer excellent thermal properties, they show technical limitations, besides environmental concerns, which have encouraged the research on alternative solutions. This work reviews the main research works on the use of gases as heat transfer fluid in linear concentrating collectors, including solar power and heat production, highlighting the potential applications and technical challenges. The review indicates: first, gases offer potential to replace liquids, and second, there is a need for more research and development to define the best technical compromises to reach practical application in every sector.This article is categorized under:
Sustainable Energy > Solar Energy
Energy and Power Systems > Energy Infrastructure
Israeli National Protection Strategies and Realities
Authors: Spitka Timea 
Published: April 2023

AbstractThis chapter unravels the enigmas between principles, practices and perceptions (PPP) of human security by Israeli authority within Israel and the Occupied Palestinian Territories. Actions in the name of security have justified severe security measures but under which circumstances have they had a positive or an inverse effect on the protection of vulnerable civilians? Unpacking security principles and practices of Israeli leadership, the IDF (Israel Defence Forces), Israeli police, secret service and non-state security agencies, this chapter examines the priorities and the effectiveness of protection of civilians. The chapter examines PPP of human protection based on documentation, surveys and interviews with national and international protectors.
Effects of high-energy laser peening followed by pre-hot corrosion on stress relaxation, microhardness, and fatigue life and strength of single-crystal nickel CMSX-4® superalloy
Authors: Morar Nicolau Iralal , Holtham Noah , Hackel Lloyd , Davami Keivan , Sharma Montu , DeWald Adrian , Roy Rajkumar 
Published: April 2023

AbstractThis study investigated the stress relaxation and fatigue life and strength of laser-peened single-crystal nickel superalloy specimens compared to unpeened and shot-peened specimens following hot corrosion exposure and then fatigue testing. The specimens were treated by conventional laser peening and a new cyclic laser peening plus thermal microstructure engineering process. The latter treatment supports the benefit of a unique process involving application of layers of laser peening using high energy with large footprint spots combined with interspersed cyclic annealing. Stress measurements by slitting showed the plastic penetration depth of laser peening exceeded shot peening by a factor of 24. Unpeened and peened specimens were exposed to sulphate corrosives at 700 °C for 300 h and then fatigue tested. Tests of five non-laser-peened specimens all failed in low-cycle fatigue regime, whereas three identically tested laser-peened specimens all achieved multi-million-cycle runout without failure, indicating fully consistent large benefit for life by laser peening. Additional tests also showed fatigue strength improvement of 2:1 by laser peening. Residual stress measurements post hot-corrosion exposure and fatigue testing showed notable 5 mm depth retention of residual eigenstress in a laser-peened specimen.
BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia
Authors: Sordo-Bahamonde Christian , Lorenzo-Herrero Seila , Martínez-Pérez Alejandra , Gonzalez-Rodriguez Ana P. , Payer Ángel R. , González-García Esther , Aguilar-García Candelaria , González-Rodríguez Sara , López-Soto Alejandro , García-Torre Alejandra , Gonzalez Segundo 
Published: April 2023

AbstractPatients with chronic lymphocytic leukemia (CLL) progressively develop marked immunosuppression, dampening innate and adaptive-driven antitumor responses. However, the underlying mechanisms promoting immune exhaustion are largely unknown. Herein, we provide new insights into the role of BTLA/HVEM axis promoting defects in T cell-mediated responses against leukemic cells. Increased expression of BTLA, an inhibitory immune checkpoint, was detected on the surface of CD4 + and CD8 + T lymphocytes in patients with CLL. Moreover, high levels of BTLA on CD4 + T cells correlated with diminished time to treatment. Signaling through BTLA activation led to decreased IL-2 and IFN-γ production ex vivo, whereas BTLA/HVEM binding disruption enhanced IFN-γ + CD8 + T lymphocytes. Accordingly, BTLA blockade in combination with bispecific anti-CD3/anti-CD19 antibody promoted CD8 + T cell-mediated anti-leukemic responses. Finally, treatment with an anti-BLTA blocking monoclonal antibody alone or in combination with ibrutinib-induced leukemic cell depletion in vitro. Altogether, our data reveal that BTLA dysregulation has a prognostic role and is limiting T cell-driven antitumor responses, thus providing new insights about immune exhaustion in patients with CLL.
Comparison of Efficacy and Safety of Laparoscopic Holmium laser Lithotripsy and Laparoscopic Bile Duct Exploration for Bile Duct Stones: A Systematic Review and Meta‐Analysis
Authors: Liu Bin , Fu Liangyin , Lu Tingting , Zhang Guangming , Dong Xiaohua , Zhao Qiqi , Yu Miao , Ma Haizhong , Yang Kehu , Cai Hui 
Published: April 2023

AbstractBackgroundLaparoscopic holmium laser lithotripsy (LHLL) has been used to treat bile duct stones with unclear outcomes. A meta‐analysis was conducted to investigate the LHLL and laparoscopic bile duct exploration (LBDE) efficacy and safety in treating bile duct stones.MethodsThe correlational studies were searched databases, such as PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP, to identify eligible studies from inception to July 2022. The dichotomous and continuous outcomes were evaluated using odds ratio (OR), risk difference (RD) and weighted mean difference (WMD) with 95% confidence intervals (CIs). Stata 15.0 and Review Manager 5.3 software helped in data analyses.ResultsA total of 23 studies with 1,890 patients, primarily from China, were included. The results indicated that operation time (WMD = − 26.94; 95% CI:(− 34.30, − 19.58); P < 0.00001), estimated blood loss (WMD = − 17.97; 95% CI: (− 22.94, − 13.00); P = 0.002), rate of residual stone (OR = 0.15, 95%CI: (0.10, 0.23); P < 0.00001), length of hospital stay (WMD = − 2.88; 95% CI:(− 3.80, − 1.96); P < 0.00001) and time to bowel function recovery (WMD = − 0.59; 95% CI: (− 0.76, − 0.41); P < 0.00001) had statistically significant differences between the two groups. In postoperative complications, biliary leakage (RD = ‐0.03; 95% CI: (− 0.05, ‐0.00); P = 0.02), infection (RD = − 0.06; 95% CI: (− 0.09,− 0.03); P < 0.00001) and Hepatic injury (RD = − 0.06; 95% CI: (− 0.11, − 0.01); P = 0.02) revealed statistically significant differences. However, no significant differences were observed in biliary damage (RD = − 0.03; 95% CI: (− 0.06, 0.00); P = 0.06) and hemobilia (RD = − 0.03; 95% CI: (− 0.06, 0.00); P = 0.08).ConclusionThe current meta‐analysis indicated that LHLL could be more effective and safer than LBDC. However, these results should be confirmed with a larger sample size and rigorously designed randomized controlled trials.
Meshing using neural networks for improving the efficiency of computer modelling
Authors: Lock Callum , Hassan Oubay , Sevilla Ruben , Jones Jason 
Published: April 2023

AbstractThis work presents a novel approach capable of predicting an appropriate spacing function that can be used to generate a near-optimal mesh suitable for simulation. The main objective is to make use of the large number of simulations that are nowadays available, and to alleviate the time-consuming mesh generation stage by minimising human intervention. For a given simulation, a technique to produce a set of point sources that leads to a mesh capable of capturing all the features of the solution is proposed. In addition, a method to combine all sets of sources for the simulations available is devised. The global set of sources is used to train a neural network that, for some design parameters (e.g., flow conditions, geometry), predicts the characteristics of the sources. Numerical examples, in the context of three dimensional inviscid compressible flows, are considered to demonstrate the potential of the proposed approach. It is shown that accurate predictions of the required spacing function can be produced, even with reduced training datasets. In addition, the predicted near-optimal meshes are utilised to compute flow solutions, and the results show that the computed aerodynamic coefficients are within the required accuracy for the aerospace industry. An analysis is also presented to demonstrate that the proposed method lies in the category of green AI research, meaning that computational resources and time are substantially reduced with this approach, when compared to current practice in industry.
Contrast sensitivity function under three light conditions in patients with type 1 diabetes mellitus without retinopathy: a cross-sectional, case–control study
Authors: Silva-Viguera María-Carmen , García-Romera Marta C. , Bautista-Llamas María-José 
Published: April 2023

Abstract
Purpose
To determine whether patients with type 1 diabetes mellitus (T1DM), without any sign of diabetic retinopathy, have any alteration in Contrast Sensitivity Function (CSF), in relation to patients without this disease, and whether CSF assessment in three different light conditions can be an effective test in the early detection of diabetic retinopathy.

Methods
A prospective, cross-sectional, case-control study was preformed including 80 patients (40 with T1DM without diabetic retinopathy and 40 controls) between 11 and 47 years old. CSF was assessed at four spatial frequencies (3, 6, 12 and 18 cycles/degree) using the CSV-1000E test, under three light conditions: high (550 lx), medium (200 lx) and low (< 2 lx).

Results
A lower CSF in the T1DM group was found at the three light conditions studied. The most spatial frequency affected was 18 cpd, 0.08 log units (p = 0.048) in high, 0.10 log units (p = 0.010) in medium (p = 0.010) and 0.16 log units (p < 0.001) in low-light conditions in mean CS values. The least spatial frequency affected was 3 cpd (p > 0.05 in all three light conditions).

Conclusion
Patients with T1DM, without diabetic retinopathy, presented a loss of CS to sine-wave gratings, with respect to people with the same characteristics without the disease, mainly at medium and high frequencies, and in medium and low-light conditions.
Comparing the responses of grain fed feedlot cattle under moderate heat load and during subsequent recovery with those of feed restricted thermoneutral counterparts: metabolic hormones
Authors: Wijffels G. , Sullivan M. L. , Stockwell S. , Briscoe S. , Anderson S. T. , Li Y. , de Melo Costa C. C. , McCulloch R. , Olm J. C. W. , Cawdell-Smith J. , Gaughan J. B. 
Published: April 2023

AbstractWe set out to determine the impact of moderate heat load on the plasma concentrations of a suite of hormones involved in regulating energy metabolism and feed intake. The responses of the thermally challenged (TC) feedlot steers were compared to those of feed restricted thermoneutral (FRTN) steers. Two sequential cohorts of twelve 518 ± 23 kg Black Angus steers on finisher grain ration were housed in climate-controlled rooms (CCR) for 18 days and returned to outdoor pens for 40 days. The TC group was subjected to a diurnal range of 28–35 °C for 7 days (Challenge) but held in thermoneutral conditions beforehand (PreChallenge), and in Recovery (after Challenge). The FRTN group was held in thermoneutral conditions and feed restricted throughout. Blood was collected over the three periods in CCR and two periods in outdoor pens for 40 days (PENS and Late PENS). Plasma concentrations of prolactin, thyroid stimulating hormone, insulin, leptin, adiponectin and thyroxine (T4) were determined during the five periods. Whilst the pituitary hormones were relatively stable, there were differences in plasma leptin, adiponectin and T4 between the two groups during Challenge and Recovery, and occasionally in PENS. The interaction of the plasma hormone concentrations and rumen temperature and DMI were also investigated. Whilst the positive relationship between DMI and leptin was confirmed, we found a strong negative relationship between adiponectin and rumen temperature, and a strong positive relationship between adiponectin and dry matter intake (DMI) in the TC steers only.
Visualization of clinically silent, odontogenic maxillary sinus mucositis originating from periapical inflammation using MRI: a feasibility study
Authors: Burian Egon , Feuerriegel Georg , Sollmann Nico , Burian Gintare , Palla Benjamin , Griesbauer Magdalena , Bumm Caspar , Probst Monika , Beer Meinrad , Folwaczny Matthias 
Published: April 2023

Abstract
Objectives
Maxillary sinus mucositis
is frequently associated with odontogenic foci. Periapical inflammation of maxillary molars and premolars cannot be visualized directly using radiation-based imaging. The purpose of this study was to answer the following clinical question: among patients with periapical inflammatory processes in the maxilla, does the use of magnetic resonance imaging (MRI), as compared to conventional periapical (AP) and panoramic radiography (OPT), improve diagnostic accuracy?

Methods
Forty-two subjects with generalized periodontitis were scanned on a 3 T MRI. Sixteen asymptomatic subjects with mucosal swelling of the maxillary sinus were enrolled in the study. Periapical edema was assessed using short tau inversion recovery (STIR) sequence. Apical osteolysis and mucosal swelling were assessed by MRI, AP, and OPT imaging using the periapical index score (PAI). Comparisons between groups were performed with chi-squared tests with Yates’ correction. Significance was set at p < 0.05.

Results
Periapical lesions of maxillary premolars and molars were identified in 16 subjects, 21 sinuses, and 58 teeth. Bone edema and PAI scores were significantly higher using MRI as compared to OPT and AP (p < 0.05). Using the STIR sequence, a significant association of PAI score > 1 and the presence of mucosal swelling in the maxillary sinus was detected (p = 0.03).

Conclusion
Periapical inflammation and maxillary mucositis could be visualized using STIR imaging. The use of MRI may help detect early, subtle inflammatory changes in the periapical tissues surrounding maxillary dentition. Early detection could guide diagnostic criteria, as well as treatment and prevention.
The clinical impacts of postoperative complications after colon cancer surgery for the clinical course of adjuvant treatment and survival
Authors: Aoyama Toru , Oba Koji , Honda Michitaka , Muto Masaru , Mayanagi Shuhei , Maeda Hiromichi , Kanda Mitsuro , Kashiwabara Kosuke , Sakamoto Junichi , Yoshikawa Takaki 
Published: April 2023

Abstract
Aim
We investigated whether or not postoperative complications (POCs) themselves have a negative survival impact or indirectly worsen the survival due to insufficient adjuvant chemotherapy in a pooled analysis of two large phase III studies performed in Japan

Patients and methods
The study examined the patients who enrolled in 1304, phase III study comparing the efficacy of 6 and 12 months of capecitabine as adjuvant chemotherapy for stage III colon cancer patients and in 882, a phase III study to confirm the tolerability of oxaliplatin, fluorouracil, and l-leucovorin in Japanese stage II/III colon cancer patients. In our study, POCs were defined as the following major surgical complications: anastomotic leakage, pneumonia, bowel obstruction/ileus, surgical site infection, postoperative bleeding, urinary tract infection, and fistula. Patients were classified as those with POCs (C group) and those without POCs (NC group).

Results
A total of 2095 patients were examined in the present study. POCs were observed in 169 patients (8.1%). The overall survival (OS) rates at 5 years after surgery were 75.3% in the C group and 86.5% in the NC group (p = 0.0017). The hazard ratio of POCs for the OS in multivariate analysis was 1.70 (95% confidence interval, 1.19 to 2.45; p = 0.0040). The time to adjuvant treatment failure (TTF) of adjuvant chemotherapy was similar between the groups, being 68.6% in the C group and 67.1% in the NC group for the 6-month continuation rate of adjuvant chemotherapy. The dose reduction rate of adjuvant chemotherapy and adjuvant treatment suspension rate were also similar between the groups (C vs. NC groups: 45.0% vs. 48.7%, p = 0.3520; and 52.7% vs. 55.0%, p = 0.5522, respectively).

Conclusion
POCs were associated with a poor prognosis but did not affect the intensity of adjuvant chemotherapy. These results suggested that POCs themselves negatively influence the survival.