bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diode laser myringotomy for short-term middle-ear ventilation: a pilot study on children
Authors: Hegazy Hassan M. 
Published: September 2023

EnAbstract
Objective
The aim of the study was to evaluate diode laser myringotomy (DLM) in children for the management of Eustachian tube and middle-ear disorders that require myringotomy for short-term treatment.

Study design
This is a prospective clinical study.

Patients and methods
The study comprised 20 children selected to undergo DLM for middle-ear ventilation as a mode of treatment for recurrent acute serous otitis media; these children suffered from persistent middle-ear effusion and had experienced failure of medical treatment for at least 8 weeks. Postoperative weekly visits to evaluate the myringotomy opening (MO) were carried out until healing was recorded. The Eustachian tube and hearing ability were evaluated preoperatively and postoperatively 4 weeks after healing of the tympanic membrane. Cases were deemed to be failed when the MO closed early within the second week postoperatively without improvement in hearing, or the myringotomy persisted until the end of the third month postoperatively. Outcome measures were the state of the MO and of the ear drum, the patency time of the myringotomy, improvement in hearing and Eustachian tube function and incidence of operative and postoperative complications.

Results
The mean operative time was 5 min. No operative complications occurred. Procedural success was achieved in 16/20 ears (80%). Two ears showed postoperative persistent perforations, and two recorded early closure of the MO. The mean improvement in the air/bone gap was 12 dB for the successful cases. Twelve ears with healed MOs showed type A curve (75%). Four ears showed type C curve (25%) and needed further management.

Conclusion
DLM is useful in children for the management of Eustachian tube and middle-ear disorders needing myringotomy for short-term treatment.
Role of virtual bronchoscopy in foreign body inhalation in children
Authors: Hassan Mohamed A. , Youssef Tamer A. , El-Gharib Mohamed 
Published: September 2023

EnAbstract
Objective
To investigate the usefulness of three-dimensional images on the basis of multidetector computer tomography (MDCT) in the evaluation of suspected foreign body (FB) aspiration in children.

Patients and methods
A total of 28 children presented to Ain Shams University hospital with suspected FB inhalation. All patients underwent chest radiographs. Of the patients, eight with inconclusive history, physical examination, and negative radiograph findings for FB inhalation underwent MDCT. All patients underwent rigid bronchoscopy (RB) and the results were compared with the findings of chest radiographs and virtual bronchoscopy images.

Results
Four patients were negative by radiography and MDCT scan, and were subjected to RB, with no FB found. The other four patients who were negative by radiography turned out to be positive by MDCT and were subjected to RB, which was positive for FB in only 3 patients. MDCT had a negative predictive value of 100%, whereas its positive predictive value was 75%.

Conclusion
RB should always be performed as a first-line procedure in the presence of a combination of characteristic clinical and radiographic signs. In the other patients, the presence of FB can be confirmed by MDCT in order to reduce the negative RB rate.
Assessing the applications of cortical auditory evoked potentials as a biomarker in children with cochlear implants
Authors: Mostafa Ismail Zohdi , Shabana Mohamed Ibrahim , El Shennawy Amira Maged , Weheiba Hoda Mahmoud 
Published: September 2023

EnAbstract
Background
Cortical auditory evoked potentials (CAEPs) are noninvasive measures used to quantify central auditory system function in humans. More specifically, the P1–N1–P2 cortical auditory evoked potential has a unique role in identifying the central auditory system that has benefited from amplification or implantation. P1 reflects the maturation of the auditory system in general as it has developed over time.

Objective
The aims of this study were to assess the CAEP in children with cochlear implants compared with age-matched controls, to study the different variables affecting the results, and to compare the pattern of P1 CAEP in cochlear implant patients compared with that in those with hearing aids.

Methodology
Thirty-five hearing-impaired children (using cochlear implants) were compared with 20 age-matched and sex-matched children with normal hearing. In both groups, P1 CAEP latency and waveform morphology were recorded using free-field auditory stimulation with tone bursts at 500 and 2000 Hz at 100 dB sound pressure level in two sessions that were 6 months apart.

Results
Children using cochlear implants exhibited prolongation of P1 latencies, indicating an overall delay in maturation when compared with that in children who could hear normally. P1 CAEP latency and amplitude improved significantly after 6 months of device use.

Conclusion
Standardized age-appropriate normative data on P1 CAEPs in the pediatric Egyptian population could be used to determine implantation or amplification results.
Lancement de la révision de la CIDIH
Authors: van Stokkom Sonja Calais , Pfeiffer Jan , Tremblay Georges , Eldar R. , Ferngren Harry , Campbell Brown Scott , Hamonet Claude 
Published: September 2023

En 1990 la revue du Réseau International de la CIDIH a publié le Volume 3, numéro 3 intitulé « Lancement de la révision de la CIDIH ». Il nous fait plaisir de republier ce volume complet dans cet article qui regroupe ainsi les différentes visions des professionnels experts de la CIDIH venant de différents pays.
Problem Faced by the Farmers in Using Information Communication Technology Tools for receiving Rice Production Information
Authors: Rahman M. S. , Ali M. S. , Kabir M. H. , Alam M. M. 
Published: September 2023

The facilitation of technology transfer to farmers plays a crucial role in enhancing agricultural productivity within the context of Bangladesh. In relation to this matter, a study was undertaken to evaluate the extent of problems faced by the farmers in utilizing Information Communication Technology (ICT) technologies for accessing rice production information. Data were collected from randomly selected 340 ICT tool using rice farmers of four selected districts of Bangladesh. The results indicated that majority (66.2%) of the rice farmers faced severe problem, compared to 27.9% and 5.9% of them faced moderate and low problem respectively in using ICT tools for receiving rice production technologies. Based on Standardized Problem Faced Index, top five severe problems were lack of ICT knowledge of farmers, high cost of internet packages, lack of training in using of ICT tools, high cost of ICT tools and required more time to learn using ICT tools. These problems may be minimized by providing necessary training to the farmers on using ICT tools for receiving rice production information, cost reduction of internet package and ICT tools, providing better internet connectivity, uninterrupted power supply as perceived by the farmers.
A Study on the Combination Prediction of Anhui Residents’ Consumption Level Based on the IOWA Operator
Authors: Li Zihan 
Published: September 2023

Aims: In order to study the future trend of Anhui residents’ consumption level and predict the consumption level of Anhui residents in the next three years (2022-2024), this paper constructs a combination prediction model based on the induced ordered weighted averaging (IOWA) operator.
Study Design: This paper selects the national resident consumption level in Anhui province from 2000 to 2021, which covers a period of 21 years. Based on the data, an IOWA operator combination prediction model is constructed using a multiple regression model, ARIMA (2,2,0) model, and machine learning decision tree model. This is a qualitative analytical study which set the sum of squared errors as dependent variables and error value of different single item prediction method as independent variables.
Place and Duration of Study: This paper selects the national resident consumption level in Anhui Province from 2000 to 2021.
Methodology: This paper constructs a combination prediction model based on the IOWA operator based on the multiple regression model, ARIMA (2,2,0) model, and machine learning decision tree model. The combination prediction method that minimizes the sum of squared errors is used to predict the consumption level of Anhui residents in the next three years (2022-2024), and the effectiveness of the IOWA operator-based combination prediction model is evaluated.
Results: This study finds that the prediction accuracy of the IOWA operator-based combination prediction model is generally greater than that of individual prediction models, and the sum of squared errors is generally significantly lower than that of individual prediction models.
Conclusion: The prediction results show that the consumption level of Anhui residents in the next three years will not fluctuate greatly, but will have a trend of slight increase. The results of this study can be helpful for the government to improve the consumption level of residents in Anhui Province.
Effect of Irrigation Scheduling Based-IW/CPE Ratio on Soil Qualities, Growth Characteristics and Yield of Wheat (Triticum aestivum L.) Crop in Eastern Uttar Pradesh, India
Authors: Pal S. , Kumar S. , Bharteey P. K. , Bahuguna A. , Kumar D. , Kumar A. , Yadav G. , Singh D. P. , Gaur A. S. 
Published: September 2023

This study aimed to assess the Effect of irrigation scheduling based on the IW/CPE ratio on soil qualities, growth characteristics and yield of wheat in Eastern Uttar Pradesh. A field experiment was conducted during rabi season of the year 2016-17. In this experiment, the treatment combinations consisting of five irrigation levels viz., CRI stage (I1), 0.6 IW/CPE ratio (I2), 0.8 IW/CPE ratio (I3), 1.0 IW/CPE ratio (I4), and 1.2 IW/CPE ratio (I5) were tried in randomized block design. Whereas the initial irrigation of all treatments is done at the CRI stage (21 DAS), and then, according to the IW/CPE ratio treatments, the crop of the net plot area was harvested from the individual plot for observation. The final seed weight per plot was recorded in kg and converted to q/ha. The result showed the growth attributes, viz., plant height, dry matter accumulation, number of effective shoots per m2, and yield-attributing characters, viz., 1000 grain weight, harvest index, grain, straw, and Biological yield by crop was significantly higher at 1.0 IW/CPE ratio (I4) in the moisture regime, which was at par with 1.2 IW/CPE ratio (I5) in the moisture regime and significantly higher than at the CRI stage (I1), 0.6 IW/CPE ratio (I2), and 0.8 IW/CPE ratio (I3).
Effect of Water Hyacinth Compost and Nitrogen, Phosphorus, Potassium, Sulfur Fertilizers on S-Availability, S-Uptake, and Quality and Yield of Onion (Allium ascalonicum L.) on Inceptisols of Jatinangor
Authors: Sofyan Emma Trinurani , Joy Benny , Sara Dirga Sapta , Santana Dwika Graha 
Published: September 2023

Shallots are have a high potential in Indonesian agricultural land. Soil in Indonesia is dominated by Inceptisols, which is low in soil fertility. This can be managed by adding nutrients to soil to increase its fertility, which can have a good effect on quality and crop yields. This experiment's purpose was to find the dosage of water hyacinth compost and N, P, K, S fertilizers that can give the best results for available S, S uptake, quality,and the yield of Batu Ijo variety of shallots in Inceptisols of Jatinangor and were carried out in the Soil Chemistry Laboratory, Plant Nutrition Experimental Garden, Faculty of Agriculture, Padjadjaran University, Jatinangor, Sumedang, West Java, Indonesia from June to September 2020. The experiment used a Randomized Completely Block Design (RCBD) with seven treatments and four replications, namely: control; Recommended N, P, K, S; ¾ Recommendations of N, P, K, S; ½ compost + ¾ dose of N, P, K, S; compost + ¾ dose of N, P, K, S; 1½ compost + ¾ dose of N, P, K, S; and compost + N, P, K, S at dosage of 25 t ha-1 water hyacinth compost, 200 kg urea, 500 kg Ammonium Sulphate, 300 kg SP-36, 200 kg KCl. The results showed that ½ compost + ¾ dose of N, P, K, S gave the best result by increasing S-avallability, S-uptake, aroma, color, number of bulbs, fresh weight, and dry weight of shallots bulbs on Inceptisols of Jatinangor.
Changes in Diagnoses and Site of Care for Patients Receiving Hospice Care From Agencies Acquired by Private Equity Firms and Publicly Traded Companies
Authors: Braun Robert Tyler , Unruh Mark A. , Stevenson David G. , Prigerson Holly G. , Fernandez Rahul , Yao Leah Z. , Casalino Lawrence P. 
Published: September 2023

ImportancePrivate equity firms and publicly traded companies have been acquiring US hospice agencies; an estimated 16% of US hospice agencies are owned by private equity (PE) firms or publicly traded companies (PTC).ObjectiveTo examine the association of PE and PTC acquisitions of hospices with Medicare patients’ site of care and clinical diagnoses.Design, Setting, and ParticipantsThis cohort study of US hospice agencies used a novel national database of acquisitions merged with the Medicare Post–Acute Care and Hospice Public Use File for 2013 to 2020. Changes in sites of care and patient characteristics for hospice agencies acquired by PE or PTCs were compared with changes for patients in nonacquired for-profit hospice agencies.ExposurePrivate equity and publicly traded company acquisitions.Main Outcomes and MeasuresThis study used a difference-in-differences approach within an event-study framework to examine the association of PE and PTC acquisitions of hospice agencies with changes in patient diagnoses and sites of care. Dependent variables were annual hospice-level measures of the Hierarchical Condition Category (HCC) score and proportion of patients diagnosed with cancer or dementia. Sites of care included the proportion of patients receiving hospice care in their personal home, nursing home, or assisted living facility.ResultsA total of 158 hospice agencies acquired by PEs, 250 acquired by PTCs, and 1559 other for-profit hospice agencies were included. Preacquisition, hospice agencies that would later be acquired by PE or PTC served a mean (IQR) 30.1% (12.0%-44.0%) and 29.4% (13.0%-43.0%) of their patients in nursing homes respectively, a greater proportion compared with the 27.1% (8.0%-43.8%) served by for-profit hospices that were never acquired. Agencies acquired by PE between 2014 and 2019 saw a significant relative increase of 5.98% in dementia patients (1.38 percentage points; 95% CI, 0.35-2.40 percentage points; P = .008). In PTC-owned hospices, the proportion of patients receiving care at home increased by 5.26% (2.98 percentage points; 95% CI, 1.46-4.51 percentage points; P &amp;lt; .001), the proportion of dementia patients rose by 13.49% (3.11 percentage points; 95% CI, 2.14-4.09 percentage points; P &amp;lt; .001), and the HCC score decreased by 1.37% (−3.19 percentage points; 95% CI, −5.92 to −0.47 percentage points; P = .02).Conclusions and RelevanceThese findings suggest that PE and PTCs select patients and sites of care to maximize profits.
White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma
Authors: Salvalaggio Alessandro , Pini Lorenzo , Gaiola Matteo , Velco Aron , Sansone Giulio , Anglani Mariagiulia , Fekonja Lucius , Chioffi Franco , Picht Thomas , Thiebaut de Schotten Michel , Zagonel Vittorina , Lombardi Giuseppe , D’Avella Domenico , Corbetta Maurizio 
Published: September 2023

ImportanceThe prognosis of overall survival (OS) in patients with glioblastoma (GBM) may depend on the underlying structural connectivity of the brain.ObjectiveTo examine the association between white matter tracts affected by GBM and patients’ OS by means of a new tract density index (TDI).Design, Setting, and ParticipantsThis prognostic study in patients with a histopathologic diagnosis of GBM examined a discovery cohort of 112 patients who underwent surgery between February 1, 2015, and November 30, 2020 (follow-up to May 31, 2023), in Italy and 70 patients in a replicative cohort (n = 70) who underwent surgery between September 1, 2012, and November 30, 2015 (follow-up to May 31, 2023), in Germany. Statistical analyses were performed from June 1, 2021, to May 31, 2023. Thirteen and 12 patients were excluded from the discovery and the replicative sets, respectively, because of magnetic resonance imaging artifacts.ExposureThe density of white matter tracts encompassing GBM.Main Outcomes and MeasuresCorrelation, linear regression, Cox proportional hazards regression, Kaplan-Meier, and prediction analysis were used to assess the association between the TDI and OS. Results were compared with common prognostic factors of GBM, including age, performance status, O6-methylguanine-DNA methyltransferase methylation, and extent of surgery.ResultsIn the discovery cohort (n = 99; mean [SD] age, 62.2 [11.5] years; 29 female [29.3%]; 70 male [70.7%]), the TDI was significantly correlated with OS (r = −0.34; P &amp;lt; .001). This association was more stable compared with other prognostic factors. The TDI showed a significant regression pattern (Cox: hazard ratio, 0.28 [95% CI, 0.02-0.55; P = .04]; linear: t = −2.366; P = .02). and a significant Kaplan-Meier stratification of patients as having lower or higher OS based on the TDI (log-rank test = 4.52; P = .03). Results were confirmed in the replicative cohort (n = 58; mean [SD] age, 58.5 [11.1] years, 14 female [24.1%]; 44 male [75.9%]). High (24-month cutoff) and low (18-month cutoff) OS was predicted based on the TDI computed in the discovery cohort (accuracy = 87%).Conclusions and RelevanceIn this study, GBMs encompassing regions with low white matter tract density were associated with longer OS. These findings indicate that the TDI is a reliable presurgical outcome predictor that may be considered in clinical trials and clinical practice. These findings support a framework in which the outcome of GBM depends on the patient’s brain organization.
Confining Prepared Ultrasmall Nanozymes Loading ATO for Lung Cancer Catalytic Therapy/Immunotherapy
Authors: Zhang Amin , Gao Ang , Zhou Cheng , Xue Cuili , Zhang Qian , Fuente Jesus M. De La , Cui Daxiang 
Published: September 2023

AbstractNanozymes with inherent enzyme‐mimicking catalytic properties combat malignant tumor progression via catalytic therapy, while the therapeutic efficacy still needs to be improved. In this work, ultrasmall platinum nanozymes (nPt) in a confined domain of a wormlike pore channel in gold nanobipyramidal–mesoporous silica dioxide nanocomposites, producing nanozyme carriers AP‐mSi with photoenhanced peroxidase ability, are innovatively synthesized. Afterward, based on the prepared AP‐mSi, a lung‐cancer nanozymes probe (AP‐HAI) is ingeniously produced by removing the SiO2 template, modifying human serum albumin, and loading atovaquone molecules (ATO) as well as IR780. Under NIR light irradiation, inner AuP and IR780 collaborate for photothermal process, thus facilitating the peroxidase‐like catalytic process of H2O2. Additionally, loaded ATO, a cell respiration inhibitor, can impair tumor respiration metabolism and cause oxygen retention, hence enhancing IR780's photodynamic therapy (PDT) effectiveness. As a result, IR780's PDT and nPt nanozymes' photoenhanced peroxidase‐like ability endow probes a high ROS productivity, eliciting antitumor immune responses to destroy tumor tissue. Systematic studies reveal that the obvious reactive oxygen species (ROS) generation is obtained by the strategy of using nPt nanozymes and reducing oxygen consumption by ATO, which in turn enables lung‐cancer synergetic catalytic therapy/immunogenic‐cell‐death‐based immunotherapy. The results of this work would provide theoretical justification for the practical use of photoenhanced nanozyme probes.
Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment
Authors: Li Yunkun , Wu Yahui , Fang Zaixiang , Zhang Yuxin , Ding Haitao , Ren Long , Zhang Lu , Gong Qiyong , Gu Zhongwei , Luo Kui 
Published: September 2023

AbstractUnsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate and the therapeutic effect. Surface modification of these drugs with target ligands can promote their cellular internalization, but the modified drugs may be subjected to unexpected immune recognition and clearance. Herein, a phenylboronic acid (PBA) group‐shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)‐inducing agent (epirubicin, Epi) and an indoleamine 2,3‐dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for tumor chemo‐immunotherapy. This NLG919‐loaded Epi‐conjugated PEGylated dendrimers bridged with boronate bonds (NLG919@Epi‐DBP) maintains a stable nanostructure during circulation. Under a moderate acidic condition, the PBA group exposes to the sialic acid residue on the tumor cell membrane to enhance the internalization and penetration of NLG919@Epi‐DBP. At pH 5.0, NLG919@Epi‐DBP rapidly disassembles to release the incorporated Epi and NLG919. Epi triggers robust ICD of tumor cells that evokes strong immune response. In addition, inhibition of the IDO1 activity downregulates the metabolism of L‐tryptophan to kynurenine, leading to a reduction in the recruitment of immunosuppressive cells and modulation of the tumor immune microenvironment. Collectively, this promising strategy has been demonstrated to evoke robust immune response as well as remodel the immunosuppressive microenvironment for an enhanced chemo‐immunotherapeutic effect.
Transferable Highly (001) Oriented Sb2Se3 Nanorod Films on Flexible Substrates for Innovative Optoelectronic Devices
Authors: Mendes Joao Otavio , Aygur Gabriel , Michel Jesús Ibarra , Bullock James , Gómez Daniel , Della Gaspera Enrico , van Embden Joel 
Published: September 2023

AbstractThin films of antimony chalcogenides, Sb2X3 (X = S, Se, or SxSe1−x), comprised of (001) oriented nanorods are highly desirable for optoelectronic applications owing to their light trapping capacity and highly efficient charge transport along the optimally aligned quasi‐1D (Sb4X6)n ribbons. Here, highly (001) oriented Sb2Se3 nanorod (Sb2Se3NR) layers are obtained via a novel template growth method, and transfer these layers to functional substrates via a polymer‐assisted technique. Transferable layers overcome the current challenges associated with achieving oriented growth directly on the desired substrate. Using a combination of a low‐temperature processable SnO2 nanoparticle transport layer and encapsulation/etching techniques photodetector devices are fabricated with excellent electrical contact. The optimized transferred devices show broad range photoresponse with signal‐to‐noise ratios up to 105 and responsivities reaching 0.96 mA W−1. Importantly, access to low‐temperature processing enables the fabrication of flexible devices. Based on this platform, a proof‐of‐concept self‐powered flexible heart rate monitor is fabricated. The achievement of transferable Sb2Se3NR layers introduced in this work is expected to be readily applicable to generate new (001) Sb2Se3 device architectures that may otherwise not be achievable via direct deposition, with application in photoelectrochemical water splitting, battery electrodes, and solar cells.