bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANAN KEPEMIMPINAN PEREMPUAN DALAM JABATAN FUNGSIONAL ( STUDI DI PUSKESMAS SIMPANG TIGA KABUPATEN PIDIE )
Authors: Zulfikar Zulfikar 
Published: January 2023

ABSTRAK
Pemimpin memberikan pengaruh yang besar bagi setiap proses pembangunan organisasi. Kepemimpinan tidak hanya berdasarkan gender maupun ras apakah dia seorang laki-laki maupun perempuan melainkan keberhasilan dari sebuah kepemimpinan yang sesungguhnya dilihat dari efektifitas dan kualitas dari gaya kepemimpinan yang diterapkan. Tujuan penelitian ini untuk mengetahui pengaruh gaya kepemimpinan perempuan dalam meningkatkan eksistensi perempuan didalam jabatan fungsional. Jenis penelitian ini adalah penelitian deskriptif kualitatif dan sumber data yang digunakan yaitu pengumpulan data primer dan data sekunder. Berdasarkan hasil penelitian peneliti mengambil bahwa peranan kepemimpinan perempuan di Puskesmas Simpang Tiga Kabupaten Pidie sudah sangat terlihat jelas kesuksesan dalam kepemimpinannya. Peranan kepemimpinan perempuan sudah sangat berperan aktif dalam jabatan fungsional di puskesmas simpang tiga kabupaten pidie. Dalam temuan peneliti kepemimpinan perempuan sudah mampu menjalankan tugas dan tanggung jawabnya dengan baik. Pemimpin perempuan juga selalu sikap dalam menyukseskan kemajuan puskesmas simpang tiga tentunya dengan kerja sama yang efektif seta efisien dengan para pegawai puskesmas lainnya. Pemimpin puskesmas simpang tiga juga sangat berwibawa dan bertanggung jawab yang tidak kalah performa nya dengan laki-laki.Sifat kepribadian yang baik harus dijaga, serta kestabilan akan emosi ketika masalah muncul baik dari keluarga maupun kerja, sehingga tetap menghasilkan kerja yang optimal.
Micropropagation and assessment of genetic stability of Dendrobium transparens Wall. Ex Lindl. using RAPD and ISSR markers
Authors: Joshi Pusp Raj , Pandey Sushma , Maharjan Lasta , Pant Bijaya 
Published: January 2023

IntroductionDendrobium species have been widely used for many health disorders since ancient times. However, due to unrelenting collection to meet the increasing demand for their use in medication and other health products, the natural habitats of medicinal Dendrobium transparens have been devastated and are on the verge of extinction.MethodsAn efficient in-vitro propagation protocol for Dendrobium transparens using seed derived protocorms was established and genetic homogeneity of the in-vitro regenerants and the wild plant was studied. ResultsThe maximum seed germination was observed in Full strength Murashige and Skoog medium (FMS). Induction of protocorms were achieved on basal as well as half-strength MS medium. The highest number of shoot (11.9 shoots/explant) was achieved in half MS medium fortified with 100 mL/L coconut water in addition with Benzyl amino purine (BAP) 1 mg/L and Kinetin 2 mg/L. Further, elongated shoots were transferred to full and half strength MS root initiating medium supplemented with different concentration of auxins. However, a maximum of (8.3 ± 0.6, 4.9 ± 0.1 cm) roots were achieved in full MS medium fortified with 100 mL/L coconut water and Napthalene acetic acid (NAA) 1.5 mg/L. Ten rapid Random Amplified Polymorphic DNA (RAPD) and Inter Simple Sequence Repeats (ISSR) primers were used to analyze genetic stability among in-vitro and mother plant. RAPD primers produced a total of 23 fragments while ISSR primers produced a total of 16 fragments. ConclusionThe amplified bands of all the samples of in-vitro plants were similar to bands of mother plant. The present research reported here is indicating the applicability of tissue culture for true-to-type plant production and conservation of D. transperens.
Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project
Authors: Zhang Lisha , Zhang Yan , Chu Chao , Deng Fuxue , Zhou Juan , Yuan Zuyi 
Published: January 2023

BackgroundThe current burden of dyslipidemia, the pre-hospital application of statins and the association of pre-hospital statins with the severity of coronary artery disease (CAD) and in-hospital outcomes in Chinese patients with first acute coronary syndrome (ACS) are very significant and remain unclear.MethodsA total of 41,183 patients who underwent coronary angiography and were diagnosed with ACS for the first time from a nationwide registry study (CCC-ACS) were enrolled. The severity of CAD was assessed using the CAD prognostic index (CADPI). The patients were classified into statin and non-statin groups according to their pre-hospital statin treatment status. Clinical characteristics, CADPI and in-hospital outcomes were compared, and a logistic regression analysis was performed to determine whether pre-hospital statin therapy is associated with in-hospital outcomes and CADPI. A sensitivity analysis was used to further explore the issues above.ResultsThe non-statin group had more in-hospital all-cause deaths (1.2 vs. 0.8%, P = 0.010). However, no association exists between statin pretreatment and in-hospital major adverse cardiovascular events (MACEs) or all-cause deaths in the entire population and subgroups (all P &gt; 0.05). Surprisingly, statin pretreatment was associated with an 8.9% higher risk of severely obstructive CAD (CADPI ≥ 37) (OR, 1.089; 95% CI, 1.010–1.175, P = 0.028), and similar results were observed in subgroups of females, those aged 50 to 75 years, and patients with hypertension.ConclusionStatin pretreatment was not related to MACEs or all-cause death during hospital stay, but it was associated with a higher risk of increased angiographic severity in patients with first ACS.
Transcatheter mitral valve replacement versus redo surgery for mitral prosthesis failure: A systematic review and meta-analysis
Authors: Zhou Jiawei , Li Yuehuan , Chen Zhang , Zhang Haibo 
Published: January 2023

BackgroundTranscatheter mitral valve replacement (TMVR) has emerged as an alternative to redo surgery. TMVR compared with redo surgical mitral valve replacement (SMVR) in patients with mitral prosthesis failure remains limited. In this study, we performed a meta-analysis to assess the outcomes of TMVR (including valve-in-valve and valve-in-ring) versus redo surgery for mitral prosthesis failure.MethodsWe comprehensively searched the PubMed, Embase, and Cochrane library databases according to predetermined inclusion and exclusion criteria, and then we extracted data. We compared the outcomes of TMVR and redo SMVR for mitral prosthesis failure in terms of the in-hospital mortality, stroke, renal dysfunction, vascular complication, pacemaker implantation, exploration for bleeding, paravalvular leak, mean mitral valve gradient, 30-day mortality, and 1-year mortality.ResultsNine retrospective cohort studies and a total of 3,038 patients were included in this analysis. Compared with redo SMVR for mitral prosthesis failure, TMVR was associated with lower in-hospital mortality [odds ratios (OR): 0.44; 95% confidence interval (CI): 0.30–0.64; P &lt; 0.001], stroke (OR: 0.44; 95% CI: 0.29–0.67; P = 0.0001), renal dysfunction (OR: 0.52; 95% CI: 0.37–0.75; P = 0.0003), vascular complication (OR: 0.58; 95% CI: 0.43–0.78; P = 0.004), pacemaker implantation (OR: 0.23; 95% CI: 0.15–0.36; P &lt; 0.00001), and exploration for bleeding (OR: 0.24; 95% CI: 0.06–0.96; P = 0.04). Conversely, redo SMVR had lower paravalvular leak (OR: 22.12; 95% CI: 2.81–174.16; P = 0.003). There was no difference in mean mitral valve gradient (MD: 0.04; 95% CI: −0.47 to 0.55; P = 0.87), 30-day mortality (OR: 0.65; 95% CI: 0.36–1.17; P = 0.15), and 1-year mortality (OR: 0.96; 95% CI: 0.63–1.45; P = 0.84).ConclusionIn patients with mitral prosthesis failure, TMVR is associated with lower in-hospital mortality and lower occurrence of postoperative complications, except for paravalvular leak. TMVR offers a viable alternative to the conventional redo surgery in selected patients.
Home blood pressure measurement for hypertension management in the real world: Do not just measure, but share with your physician
Authors: Rhee Moo-Yong , Munakata Masanori , Nah Deuk-Young , Kim Je Sang , Kim Hae-Young 
Published: January 2023

IntroductionStudies of the effectiveness of home blood pressure (BP) measurement on the treatment of hypertension in the real world are sparse, and the results are controversial. There is an efficacy-effectiveness gap in the treatment of hypertension using home BP measurements. We aimed to investigate the effect of reporting home BP to physicians on ambulatory BP control as a factor contributing to the efficacy-effectiveness gap in treating patients with hypertension.MethodsWe recruited patients ≥20 years of age taking antihypertensive drugs. Office and 24-h ambulatory BP were measured. A questionnaire to the measurement of home BP was conducted. Participants were divided into an HBPM(−) group, home BP was not measured (n = 467); HBPM(+)-R(−) group, home BP was measured but not reported (n = 81); and HBPM(+)-R(+) group, home BP was measured and reported (n = 125).ResultsThe HBPM(+)-R(+) group had significantly lower office systolic BP (SBP, p = 0.035), 24-h SBP (p = 0.009), and daytime SBP (p = 0.016) than the HBPM(−) group, and lower nighttime SBP (p = 0.005) and diastolic BP (DBP, p = 0.008) than the HBPM(+)-R(−) group. In the multivariate analysis, the differences in 24-h SBP, daytime SBP, and nighttime DBP remained significant. There was a significant difference between groups in the target achievement rate of 24-h SBP (p = 0.046), nighttime SBP (p = 0.021), and nighttime DBP (p = 0.023). The nighttime SBP and DBP target achievement rates in the HBPM(+)-R(+) group were higher than those in the HBPM(+)-R(−) group (p = 0.006 and 0.010, respectively). Among patients measuring home BP, the adjusted odds ratio for 24-h and nighttime BP target achievement in the HBPM(+)-R(+) group were 2.233 and 3.658, respectively.ConclusionHome BP measurements should be reported to the treating physician to effectively manage hypertension.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT03868384.
Research on cemented artificial pillars to replace protective inter-block coal pillars and stope failure laws
Authors: Che Chiyuan , Cao Shenggen , Zhao Changzheng , Du Shuyu , Li Jiang , Liu Yang 
Published: January 2023

Replacing protective inter-block coal pillars (PICPs) with cemented artificial pillars is proposed here to address low coal recovery rates. The use of cemented artificial pillars also reduces resource waste when PICPs are used in the short-wall block mining (SBM) process. A coal mine test area in northern Shaanxi, China, was employed as the study site. Artificial pillar replacement techniques were developed based on the layout characteristics of a typical SBM workface. High-strength cemented backfill materials for artificial pillars were manufactured using innovative material ratio testing, and the optimum ratios for backfill materials are discussed. A cusp catastrophe model of an artificial pillar was then developed and used to deduce the conditions and critical widths necessary to generate catastrophic instability of an artificial pillar. This theoretical analysis was validated using FLAC3D simulations. Using the test site conditions, the simulations revealed that when an artificial pillar had a width of 14 m, the destruction of the pillar and associated stope was gradual and would not cause catastrophic instability. Field monitoring performed at the test site verified the theoretical analysis and numerical simulation results, confirming that it was feasible to replace PICPs with cemented artificial pillars.
Imprints of tropical cyclone on three-dimensional structural characteristics of mesoscale oceanic eddies
Authors: Zhang Zheliang , Zheng Yunxia , Li Hao 
Published: January 2023

The impact of tropical cyclones (TCs) on the three-dimensional characteristics of mesoscale oceanic eddies is investigated in this study on the basis of statistical analysis by satellite-based eddy information and Argo data. By comparing the three-dimensional structure of the temperature, salinity, and geostrophic velocity in the upper ocean above 1,000 m depth, it was found that there is a heat pump effect in the changes of eddy structure similar to that in tropical cyclones. Under the forcing of TC, the abnormal signals in the strong cold core (warm core) structure originally existing in the upper layer of the cyclonic eddy (anticyclonic eddy) are transmitted to the middle and lower layers of the eddy and form retention, making the eddy structure not recover to the original state in a short period of time. To a certain extent, this shows that the influence of TC on the eddy structure is not limited to the ocean surface. At the same time, the change of barrier layer in the eddy is explored, and it was found that the barrier layer thickness in both cyclonic eddy and anticyclonic eddy has increased, which also confirms the previous research.
Inflammatory arthritis in systemic sclerosis is associated with elevated C-reactive protein and requires musculoskeletal ultrasound for reliable detection
Authors: Feldmann Daria , Jandova Ilona , Heilmeier Ursula , Kollert Florian , Voll Reinhard E. , Finzel Stephanie 
Published: January 2023

ObjectivesAbout 25% of patients with systemic sclerosis (SSc) have elevated C-reactive protein (CRP) levels. Specific causes of CRP elevation are unknown so far. We aimed to investigate whether inflammatory arthritis is associated with CRP elevation. Furthermore, we evaluated the sensitivity and specificity of clinical examination compared to musculoskeletal ultrasound (MSUS) for detection of arthritis.MethodsSixty-five patients with SSc (51 females) were enrolled and allocated into a CRP-positive (CRP+,n= 20; CRP elevated for at least two years prior to enrollment) and a CRP-negative (CRP−;n= 45) cohort. All patients were examined clinically (modified Rodnan Skin Score, mRSS; swollen/tender joint count 66/68), received a comprehensive MSUS of their hands and feet, as well as laboratory testing (antibody status; CRP). Statistical analyses were performed using non-parametrical tests without adjustments.ResultsPatient with a disease duration &lt;3 years had higher CRP levels (p= 0.042). Anti-centromere antibodies dominated in CRP- patients (p = 0.013), and anti-Scl70 antibodies in CRP + patients (p= 0.041). Joint effusion and B-mode synovitis prevailed in male (p&lt; 0.00001;p&lt; 0.0001) and CRP + (p= 0.001;p&lt; 0.00001) patients. Power Doppler (PD)-synovitis predominated in patients with diffuse SSc (p= 0.0052). Joint effusion and B-/PD-synovitis were mostly confined to wrists, MTPs and talo-navicular joints. Compared to MSUS, sensitivity of clinical examination was as low as 14.6%; specificity was 87.7%. Sensitivity was reduced by the presence of soft tissue edema or a mRSS &gt; 10.ConclusionArthritis is more frequent in CRP + compared to CRP- SSc patients. Compared to MSUS sensitivity of clinical examination is low for the detection of arthritis; this is likely due to skin fibrosis and soft tissue edema. Therefore, regular monitoring via MSUS should be considered as routine assessment in SSc patients.
Immune infiltration analysis reveals immune cell signatures in salivary gland tissue of primary Sjögren’s syndrome
Authors: Gong Hongxiao , Qiu Xiaoting , Li Pingping , Zhao Runzhi , Wang Beijia , Zhu Ling , Huo Xingxing 
Published: January 2023

IntroductionMouse models are the basis for primary Sjögren’s syndrome (pSS) research. However, the depth of comparisons between mice and humans in salivary gland (SG) immune cells remains limited.MethodsThe gene expression profiles of SGs from normal subjects and pSS patients were downloaded from the Gene Expression Comprehensive Database. The proportion of infiltrating immune cell subsets was then assessed by cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT). An experimental Sjögren’s syndrome (ESS) mouse model was successfully constructed using SG protein. Based on mouse SG tissue RNA-Seq data, the seq-ImmuCC model was used to quantitatively analyze the compositional ratios of 10 immune cells in pSS patients and mouse model SG tissues.ResultsComputed and obtained 31 human data samples using the CIBERSORT deconvolution method. The immune cell infiltration results showed that, compared to normal human SG tissue, the content of gamma delta T cells was significantly different from naive CD4+ T cells and significantly increased, while the plasma cell content decreased. Principal component analysis indicated differences in immune cell infiltration between pSS patients and normal subjects. Meanwhile, for ESS model mouse data analysis, we found that the proportion of macrophages increased, while the proportion of CD4+ T cells, B cells, and monocytes decreased. Furthermore, we found that the proportion of monocytes was decreased, while the proportion of macrophages was increased in the SG tissues of pSS patients and model mice. The infiltration of CD4+ T, CD8+ T, and B cells also showed some differences.DiscussionWe comprehensively analyzed SG immune infiltration in pSS patients and model mice. We demonstrated conserved and nonconserved aspects of the immune system in mice and humans at the level of immune cells to help explain the primary regulation of immune mechanisms during the development of Sjögren’s syndrome.
Anti-microbial, anti-oxidant, and anti-breast cancer properties unraveled in yeast carotenoids produced via cost-effective fermentation technique utilizing waste hydrolysate
Authors: Sinha Sweta , Das Souvik , Saha Biswajit , Paul Debarati , Basu Biswarup 
Published: January 2023

IntroductionNatural carotenoids are well known for their anti-oxidant property and also shown to have antimicrobial and anticancer efficacy. Production of carotenoids from microbial resources mainly from yeast has attracted commercial interest. Breast cancer has the highest incidence among women, and therapy resistance and lack of effective therapeutic strategies are major treatment bottlenecks, particularly for triple-negative subtypes. Yeast carotenoids are recently being evaluated for affordable, non-toxic, natural product-based therapies. In the present study, we have shown an environment-friendly and inexpensive method for carotenoid production from yeasts, utilizing “mandi” wastes, and investigated the biomedical properties of carotenoids, particularly antineoplastic properties.MethodsVegetable “mandi” waste was used to prepare waste hydrolysate, a culture medium, in which oleaginous red yeast Rhodosporidium sp. was grown. Carotenoid pigments were extracted using the solvent extraction method and analyzed by UV spectroscopy, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC). Antimicrobial, antioxidant, and anticancer activities of the extract were evaluated, followed by in silico docking and absorption, distribution, metabolism, and excretion/toxicity (ADME/T) studies.ResultsCarotenoid extract was found to be composed of three main pigments-β-carotene, torulene, and torularhodin. Extract exhibited significant antioxidant, antimicrobial, and anti-breast cancer activities in vitro while being biocompatible. Interestingly, carotenoids have shown better efficacy in triple-negative breast cancer (TNBC) cells than ER+PR+ cells. In silico evaluation predicted binding with breast cancer-specific molecular targets, specifically the three components showed good binding energy toward VEGF receptors and good drug likeliness properties, as well as less toxicity.DiscussionThis is the first report on anti-breast cancer activities, particularly targeting TNBC cells by red yeast carotenoids (β-carotene, torulene, and torularhodin) produced via a sustainable environment-friendly bioprocess utilizing waste hydrolysate.
Predictors of 30-day mortality among patients with stroke admitted at a tertiary teaching hospital in Northwestern Tanzania: A prospective cohort study
Authors: Matuja Sarah Shali , Mlay Gilbert , Kalokola Fredrick , Ngoya Patrick , Shindika Jemima , Andrew Lilian , Ngimbwa Joshua , Ahmed Rashid Ali , Tumaini Basil , Khanbhai Khuzeima , Mutagaywa Reuben , Manji Mohamed , Sheriff Faheem , Mahawish Karim 
Published: January 2023

BackgroundStroke is the second leading cause of death worldwide, with the highest mortality rates in low- to middle-income countries, particularly in sub-Saharan Africa. We aimed to investigate the predictors of 30-day mortality among patients with stroke admitted at a tertiary teaching hospital in Northwestern Tanzania.MethodsThis cohort study recruited patients with the World Health Organization's clinical definition of stroke. Data were collected on baseline characteristics, the degree of neurological impairment at admission (measured using the National Institutes of Health Stroke Scale), imaging and electrocardiogram (ECG) findings, and post-stroke complications. The modified Rankin scale (mRS) was used to assess stroke outcomes. Kaplan–Meier analysis was used to describe survival, and the Cox proportional hazards model was used to examine predictors of mortality.ResultsA total of 135 patients were enrolled, with a mean age of 64.5 years. Hypertension was observed in 76%, and 20% were on regular anti-hypertensive medications. The overall 30-day mortality rate was 37%. Comparing patients with hemorrhagic and ischemic stroke, 25% had died by day 5 [25th percentile survival time (in days): 5 (95% CI: 2–14)] versus day 23 [25th percentile survival time (in days): 23 (95% CI: 11–30) (log-rank p &lt; 0.001)], respectively. Aspiration pneumonia was the most common medical complication, occurring in 41.3% of patients. ECG abnormalities were observed in 54.6 and 46.9% of patients with hemorrhagic and ischemic stroke, respectively. The most common patterns were as follows: ST changes 29.6 vs. 30.9%, T-wave inversion 34.1 vs. 38.3%, and U-waves 18.2 vs. 1.2% in hemorrhagic and ischemic stroke, respectively. Independent predictors for case mortality were as follows: mRS score at presentation (4–5) [aHR 5.50 (95% CI: 2.02–15.04)], aspiration pneumonia [aHR 3.69 (95% CI: 1.71–13.69)], ECG abnormalities [aHR 2.28 (95% CI: 1.86–5.86)], and baseline stroke severity [aHR 1.09 (95% CI: 1.02–1.17)].ConclusionStroke is associated with a high 30-day mortality rate in Northwestern Tanzania. Concerted efforts are warranted in managing patients with stroke, with particular attention to individuals with severe strokes, ECG abnormalities, and swallowing difficulties to reduce early morbidity and mortality.