bluuebunny/crossref_metadata_2025_split huggingface dataset:
Singly TASE Operators for the Numerical Solution of Stiff Differential Equations by Explicit Runge–Kutta Schemes
Authors: Calvo Manuel , Fu Lin , Montijano Juan I. , Rández Luis 
Published: May 2023

AbstractIn this paper new explicit integrators for numerical solution of stiff evolution equations are proposed. As shown by Bassenne, Fu and Mani in (J Comput Phys 424:109847, 2021), the action on the original vector field of the stiff equations of an appropriate time-accurate and highly-stable explicit (TASE) linear operator, allows us to use explicit Runge–Kutta (RK) schemes with these modified equations so that the resulting algorithm becomes stable for the original stiff equations. Here a new family of TASE operators is considered. The new operators, called Singly TASE, have the advantage over the TASE operators of Bassenne et al. that the action on the vector field depends on the powers of the inverse of only one matrix, which can be computationally more simple, without loosing stability properties. A complete study of the linear stability properties of k–stage, kth–order explicit RK schemes under the action of Singly TASE operators of the same order is carried out for $$k \le 4$$

k
≤
4

. For orders two, three and four, particular schemes that are nearly strongly A–stable and therefore suitable for stiff problems are devised. Further, explicit RK schemes with orders three and four that can be implemented with only two storage locations under the action of Singly TASE operators of the same order are discussed. A particular implementation of the classical four–stage fourth–order RK scheme with two Singly TASE operators is presented. A set of numerical experiments has been conducted to demonstrate the performance of the new schemes by comparing with previous RKTASE and other established methods. The main conclusion is that the new integrators provide a very simple solver for stiff systems with good stability properties and avoids the difficulties of using implicit algorithms.
Mesoporous colloidal silica cubes with catalytically active cores
Authors: Sprockel Alessio J. , Dekker Frans , Tuinier Remco , Philipse Albert P. 
Published: May 2023

AbstractPreparation methods of cubic core-shell particles with specific functionality are limited. Here we demonstrate the possibility to transform cuprous oxide cubes coated with mesoporous silica into functional core-shell particles, while retaining their cubic shape. Cuprous oxide nanocubes are coated with mesoporous silica using cetyltrimethylammonium bromide as a template, after which the cuprous oxide core is transformed using liquid phase calcination and galvanic replacement. Nitrogen physisorption and electron microscopy confirm that mesoporous silica coatings are obtained with tuneable thickness. The successful transformation of cuprous oxide into gold and silver is assessed via UV–VIS spectroscopy and energy dispersive X-ray spectroscopy. Particles with a silver core and a cubic mesoporous silica shell are demonstrated to be catalytically active in the degradation of the dye Congo red.
Graphical abstract
3D reflection seismic imaging of natural gas/fluid escape features in the deep-water Orange Basin of South Africa
Authors: Maduna N. G. , Manzi M. S. D. , Bourdeau J. E. , Jinnah Z. 
Published: May 2023

AbstractMany features indicative of natural gas and oil leakage are delineated in the deep-water Orange Basin offshore South Africa using 3D reflection seismic data. These features are influenced by the translational and compressional domains of an underlying Upper Cretaceous deep-water fold-and-thrust belt (DWFTB) system detaching Turonian shales. The origin of hydrocarbons is postulated to be from both: (a) thermogenic sources stemming from the speculative Turonian and proven Aptian source rocks at depth; and (b) biogenic sources from organic-rich sediments in the Cenozoic attributed to the Benguela Current upwelling system. The late Campanian surface has a dense population of > 950 pockmarks classified into three groups based on their variable shapes and diameter: giant (> 1500 m), crater (~ 700–900 m) and simple (< 500 m) pockmarks. A total of 85 simple pockmarks are observed on the present-day seafloor in the same area as those imaged on the late Campanian surface found together with mass wasting. A major slump scar in the north surrounds a ~ 4200 m long, tectonically controlled mud volcano. The vent of the elongated mud volcano is near-vertical and situated along the axis of a large anticline marking the intersection of the translational and compressional domains. Along the same fold further south, the greatest accumulation of hydrocarbons is indicated by a positive high amplitude anomaly (PHAA) within a late Campanian anticline. Vast economical hydrocarbon reservoirs have yet to be exploited from the deep-water Orange Basin, as evidenced by the widespread occurrence of natural gas/fluid escape features imaged in this study.
Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status
Authors: Tini Paolo , Yavoroska Mariya , Mazzei Maria Antonietta , Miracco Clelia , Pirtoli Luigi , Tomaciello Miriam , Marampon Francesco , Minniti Giuseppe 
Published: May 2023

Abstract
Purpose
The Ki-67/MIB-1 labeling index (LI) is clinically used to differentiate between high and low-grade gliomas, while its prognostic value remains questionable. Glioblastoma (GBM) expressing wild-type isocitrate dehydrogenase IDHwt, a relatively common malignant brain tumor in adults, is characterized by a dismal prognosis. Herein, we have retrospectively investigated the prognostic role of Ki-67/MIB-1-LI in a large group of IDHwt GBM.

Methods
One hundred nineteen IDHwt GBM patients treated with surgery followed by Stupp’s protocol in our Institution between January 2016 and December 2021 were selected. A cut-off value for Ki-67/MIB-1-LI was used with minimal p-value based approach.

Results
A multivariate analysis showed that Ki-67/MIB-1-LI expression < 15% significantly correlated with a longer overall survival (OS), independently from the age of the patients, Karnofsky performance status scale, extent of surgery and O6-methylguanine (O6-MeG)-DNA methyltransferase promoter methylation status.

Conclusions
Among other studies focused on Ki-67/MIB-1-LI, this is the first observational study showing a positive correlation between OS of IDHwt GBM patients and Ki-67/MIB-1-LI that we propose as a new predictive marker in this subtype of GBM.
Using bookmarking methods with orthopedic clinicians and patients with fractures produces score interpretation labels for patient-reported outcome measures
Authors: Rothrock Nan E. , Wilson Sandra A. , Heng Marilyn , Hodor Aleksandra , Joeris Alexander , Kaat Aaron J. , McKelvey Karma , Schalet Benjamin D. , Vrahas Mark 
Published: May 2023

Abstract
Objective
The objective of this study was to determine the patient-reported outcome measure (PROM) score ranges associated with descriptive labels (i.e., within normal limits, mild, moderate, severe) by using bookmarking methods with orthopedic clinicians and patients who have experienced a bone fracture.

Study design and setting
We created vignettes comprised of six items and responses from the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity Function, Physical Function, and Pain Interference item banks reflecting different levels of severity. Two groups of patients with fractures (n = 11) and two groups of orthopedic clinicians (n = 16) reviewed the vignettes and assigned descriptive labels independently and then discussed as a group until reaching consensus via a videoconference platform.

Results
PROMIS Physical Function and Pain Interference thresholds (T = 50, 40, 25/30 and T = 50/55, 60, 65/70, respectively) for patients with bone fractures were consistent with the results from other patient populations. Upper Extremity thresholds were about 10 points (1 SD) more severe (T = 40, 30, 25/20) compared to the other measures. Patient and clinician perspectives were similar.

Conclusion
Bookmarking methods generated meaningful score thresholds for PROMIS measures. These thresholds between severity categories varied by domain. Threshold values for severity represent important supplemental information to interpret PROMIS scores clinically.
Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems
Authors: Ferrara Maria , Fabrizio Enrico 
Published: May 2023

AbstractThe integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems, such as in Solar Assisted Geothermal Heat Pumps (SAGHP), may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts, but requires careful integrated optimization of the different system components. In particular, thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system operation. This work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field, the geothermal field and the water thermal storages. This is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility, which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system components. Results identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34% lower global cost compared to the initial design. High robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.
Populatiemanagement en nieuwe technologie in de moderne diabeteszorg: over het waarom en hoe van CloudCare
Authors: Aanstoot Henk-Jan , Last Sander , Riegman Nico , Mul Dick , Hoogendam Arjen , Akkerman Maarten , Veeze Henk 
Published: May 2023

SamenvattingDe snelle technologische ontwikkelingen in de diabeteszorg zorgen voor betere uitkomsten, maar ook voor een toename van dataverkeer tussen patiënt en zorgverleners. De noodzaak voor die verbetering van uitkomsten wordt beschreven. De stappen die daartoe zijn gezet en die nog kunnen worden gezet, zijn aan de inzet van deze technologie verbonden. Daarbij moet en kan ook de diabeteszorg worden veranderd, waardoor er op nieuwe wijze continuïteit in contacten en coaching komt en traditionele zorg (3-4 x per jaar een consult) verandert naar nieuwe virtuele en automatische vormen. Daarvoor is een verandering nodig: in plaats van dat elk contact vanuit één patiënt of behandelaar wordt gestart, wordt op basis van de glucosedata populatiemanagement van diabetes verricht. Daarbij wordt op basis van zorggegevens een (continue) triage verricht en wordt direct persoonsgerichte zorg aangeboden aan mensen die problemen ervaren of risico hebben op problemen. De combinatie van diabetestechnologie en populatiemanagementmethoden wordt aan de hand van het ontwikkelde CloudCare-systeem toegelicht.
A Decision Framework for Selecting Critically Important Nutrients from Aquatic Foods
Authors: Zamborain-Mason Jessica , Viana Daniel , Nicholas Khristopher , Jackson Erin D. , Koehn J. Zachary , Passarelli Simone , Yoo Seo-Hyun , Zhang Angela W. , Davin Hannah C. , Duggan Christopher P. , Schmidhuber Josef , Golden Christopher D. 
Published: May 2023

Abstract

Purpose of Review
Aquatic foods are increasingly being recognized as a diverse, bioavailable source of nutrients, highlighting the importance of fisheries and aquaculture for human nutrition. However, studies focusing on the nutrient supply of aquatic foods often differ in the nutrients they examine, potentially biasing their contribution to nutrition security and leading to ineffective policies or management decisions.

Recent Findings
We create a decision framework to effectively select nutrients in aquatic food research based on three key domains: human physiological importance, nutritional needs of the target population (demand), and nutrient availability in aquatic foods compared to other accessible dietary sources (supply). We highlight 41 nutrients that are physiologically important, exemplify the importance of aquatic foods relative to other food groups in the food system in terms of concentration per 100 g and apparent consumption, and provide future research pathways that we consider of high importance for aquatic food nutrition.

Summary
Overall, our study provides a framework to select focal nutrients in aquatic food research and ensures a methodical approach to quantifying the importance of aquatic foods for nutrition security and public health.
Breaching the Taboo? Constitutional Dimensions of the New Chinese Civil Code
Authors: Stone Sweet Alec , Bu Chong , Zhuo Ding 
Published: May 2023

AbstractChinese elites have celebrated its new Civil Code (2021) as the most important statute in the nation's history, and the ‘cornerstone’ of its turn toward ‘rule of law’. The Code expressly binds all persons, as well as public officials, and is judicially enforceable. The statute enshrines rights to dignity, equality, personal liberty, property, and privacy, among others, and codifies duties to protect the environment and to evolve effective means to combat sexual harassment. Echoing the German Code, the statute also contains ‘general clauses’ that enable the courts to restrict enumerated rights and entitlements for reasons of ‘good morals’, ‘public order’, and the rights of others. While constituting an act of massive delegation to the courts, judges remain prohibited from directly enforcing the PRC's Constitution. The article explores the relationship between the Code and Constitution, through a comparative analysis of: (i) the process of ‘constitutionalising’ the private law around the globe; (ii) the scholarly discourse on the ‘horizontal effect’ of rights in China; (iii) the structure of the Code itself; and (iv) the development of ‘political’ control mechanisms, to be deployed by the Communist Party of China and organs of the state to constrain how judges use their interpretive powers.
Business and Human Rights in Central and Eastern Europe: Constitutional Law as a Driver for the International Human Rights Law
Authors: Szoszkiewicz Łukasz 
Published: May 2023

AbstractThis paper analyses five constitutional developments in Central and Eastern Europe that can impact the domestic implementation of the UN Guiding Principles on Business and Human Rights (UNGPs). Using Czechia, Poland and Slovenia as examples, the paper highlights four potential drivers, namely: (1) the process of constitutionalizing human rights; (2) the proliferation of the doctrine of horizontal effect of constitutional rights; (3) the constitutional legitimacy of state intervention in the free market economy; and (4) the mechanism of judicial review. Furthermore, the author underlines the most significant challenge, which is increasing resistance to international norms in some countries, e.g., Poland. The paper concludes that the jurisprudence of the constitutional courts can facilitate the domestic implementation of the UNGPs, particularly Pillars I (State duty to protect human rights) and III (access to remedy).
Clinical applications of contactless photoplethysmography for vital signs monitoring in pediatrics: A systematic review and meta-analysis
Authors: Bautista Melissa , Cave Daniel , Downey Candice , Bentham James R. , Jayne David 
Published: May 2023

Abstract

Background:
Contactless photoplethysmography (PPG) potentially affords the ability to obtain vital signs in pediatric populations without disturbing the child. Most validity studies have been conducted in laboratory settings or with healthy adult volunteers. This review aims to evaluate the current literature on contactless vital signs monitoring in pediatric populations and within a clinical setting.

Methods:
OVID, Webofscience, Cochrane library, and clinicaltrials.org were systematically searched by two authors for research studies which used contactless PPG to assess vital signs in children and within a clinical setting.

Results:
Fifteen studies were included with a total of 170 individuals. Ten studies were included in a meta-analysis for neonatal heart rate (HR), which demonstrated a pooled mean bias of −0.25 (95% limits of agreement (LOA), −1.83 to 1.32). Four studies assessed respiratory rate (RR) in neonates, and meta-analysis demonstrated a pooled mean bias of 0.65 (95% LOA, −3.08 to 4.37). All studies were small, and there were variations in the methods used and risk of bias.

Conclusion:
Contactless PPG is a promising tool for vital signs monitoring in children and accurately measures neonatal HR and RR. Further research is needed to assess children of different age groups, the effects of skin type variation, and the addition of other vital signs.
Approaches for enhancing the informativeness and quality of clinical trials: Innovations and principles for implementing multicenter trials from the Trial Innovation Network
Authors: Lane Karen , Palm Marisha E. , Marion Eve , Kay Marie T. , Thompson Dixie , Stroud Mary , Boyle Helen , Hillery Shannon , Nanni Angeline , Hildreth Meghan , Nelson Sarah , Burr Jeri S. , Edwards Terri , Poole Lori , Waddy Salina P. , Dunsmore Sarah E. , Harris Paul , Wilkins Consuelo , Bernard Gordon R. , Dean J. Michael , Dwyer Jamie , Benjamin Daniel K. , Selker Harry P. , Hanley Daniel F. , Ford Daniel E. 
Published: May 2023

Abstract
One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects of trial planning and execution. The multicenter model can provide the potential for a more informative environment, but it can also place a trial at risk of becoming uninformative due to lack of rigor, quality control, or effective recruitment, resulting in premature discontinuation and/or non-publication. Key factors that support informativeness are having the right team and resources during study planning and implementation and adequate funding to support performance activities. This communication draws on the experience of the National Center for Advancing Translational Science (NCATS) Trial Innovation Network (TIN) to develop approaches for enhancing the informativeness of clinical trials. We distilled this information into three principles: (1) assemble a diverse team, (2) leverage existing processes and systems, and (3) carefully consider budgets and contracts. The TIN, comprised of NCATS, three Trial Innovation Centers, a Recruitment Innovation Center, and 60+ CTSA Program hubs, provides resources to investigators who are proposing multicenter collaborations. In addition to sharing principles that support the informativeness of clinical trials, we highlight TIN-developed resources relevant for multicenter trial initiation and conduct.
Redesigning design thinking for codesign with nondesigners: a method efficiency perspective
Authors: Efeoğlu Arkın , Møller Charles 
Published: May 2023

AbstractPrevious research on design thinking (DT) has focused mainly on describing and explaining observed phenomena rather than manipulating variables within the boundaries of its principles to assess the impact of these changes. DT, as a human-centric problem-solving and innovation method, has varying baseline exposure levels of nondesigners and novices when codesigning. This qualitative research shows how DT can be redesigned to accommodate the inclusion and engagement of novices and nondesigners in the codesign process with enhanced DT method applicability. DT novices and nondesigners are challenged in codesign engagements with others and need an intuitive method that leads them to the same or better design results as a classic DT method. A redesign towards an intuitive DT method for nondesigners puts special consideration on method language, efficiency and cycle time. A case study validates its qualification under real-life circumstances when codesigning with DT novices and nondesigners. Overall, the research demonstrates that DT with regard to nondesigners can be simplified and redesigned for efficiency and effectiveness.
Effect of subsurface impurity defects on laser damage resistance of beam splitter coatings
Authors: Du Wenyun , Zhu Meiping , Shi Jun , Liu Tianbao , Sun Jian , Yi Kui , Shao Jianda 
Published: May 2023

Abstract
The laser-induced damage threshold (LIDT) of plate laser beam splitter (PLBS) coatings is closely related to the subsurface absorption defects of the substrate. Herein, a two-step deposition temperature method is proposed to understand the effect of substrate subsurface impurity defects on the LIDT of PLBS coatings. Firstly, BK7 substrates are heat-treated at three different temperatures. The surface morphology and subsurface impurity defect distribution of the substrate before and after the heat treatment are compared. Then, a PLBS coating consisting of alternating HfO2–Al2O3 mixture and SiO2 layers is designed to achieve a beam-splitting ratio (transmittance to reflectance, s-polarized light) of approximately 50:50 at 1053 nm and an angle of incidence of 45°, and it is prepared under four different deposition processes. The experimental and simulation results show that the subsurface impurity defects of the substrate migrate to the surface and accumulate on the surface during the heat treatment, and become absorption defect sources or nodule defect seeds in the coating, reducing the LIDT of the coating. The higher the heat treatment temperature, the more evident the migration and accumulation of impurity defects. A lower deposition temperature (at which the coating can be fully oxidized) helps to improve the LIDT of the PLBS coating. When the deposition temperature is 140°C, the LIDT (s-polarized light, wavelength: 1064 nm, pulse width: 9 ns, incident angle: 45°) of the PLBS coating is 26.2 J/cm2, which is approximately 6.7 times that of the PLBS coating deposited at 200°C. We believe that the investigation into the laser damage mechanism of PLBS coatings will help to improve the LIDT of coatings with partial or high transmittance at laser wavelengths.
Is perinatal substance abuse falling through the cracks?
Authors: Mitchell J. M. , Keenan O. , Fakhoury A. , Fitzgerald D. , Mohamad M. M. , Imcha M. 
Published: May 2023

AbstractObjectives:Perinatal substance abuse (PSA) is associated with increased risk of prematurity, low birth weight, neonatal abstinence syndrome, behavioral issues and learning difficulties. It is imperative that robust care pathways are in place for these high-risk pregnancies and that staff and patient education are optimized. The present study explores the knowledge and attitudes of healthcare professionals toward PSA to identify knowledge gaps to enhance care and reduce stigma.Methods:This is a cross-sectional study using questionnaires to survey healthcare professionals (HCPs) working in a tertiary maternity unit (n = 172).Results:The majority of HCPs were not confident in the antenatal management (75.6%, n = 130) or postnatal management (67.5%, n = 116) of PSA. More than half of HCPs surveyed (53.5%, n = 92) did not know the referral pathway and 32% (n = 55) did not know when to make a TUSLA referral. The vast majority (96.5%, n = 166) felt that they would benefit from further training, and 94.8% (n = 163) agreed or strongly agreed that the unit would benefit from a drug liaison midwife. Among study participants, 54.1% (n = 93) agreed or strongly agreed that PSA should be considered a form of child abuse and 58.7% (n = 101) believe that the mother is responsible for damage done to her child.Conclusions:Our study highlights the urgent need for increased training on PSA to enhance care and reduce stigma. It is imperative that staff training, drug liaison midwives and dedicated clinics are introduced to hospitals as a matter of high priority.