bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building “causal realism” in experimental studies within hospitality and tourism
Authors: Butcher Kenneth , Yodsuwan Chachaya 
Published: April 2023

Purpose
The purpose of this paper is to discuss the current status of experimental research within hospitality and tourism. This paper further aims to develop practical ideas for enhancing the adoption of a cause and effect mindset in researchers.

Design/methodology/approach
A mini-review of the level of experimental designs and best-practice ideas published by the top 12 journals in hospitality and tourism over a five-year period was conducted.

Findings
Although the absolute number of experimental studies is growing, the ratio of experimental studies to overall publications remains low at 6.4%. To increase the take-up of experimental design, a broader typology of field experiments is presented. Practical steps to increase causal reality are provided under the categories of purpose; scenario development; scenario testing; and sample characteristics.

Research limitations/implications
The methodological advances suggested in this paper can contribute to more robust theory development and testing. The recommendations offer guidance to a new generation of researchers seeking to add causal value to their studies, researchers collaborating with scholars from other discipline areas and hospitality managers seeking stronger evidence of cause and effect.

Originality/value
This paper identifies key obstacles to the take-up of experimental design and the contemporary status of experimental design. A novel typology of five experimental designs that distinguish the difference between experimental and correlational designs in terms of explanatory power is presented, together with a comprehensive list of best practice suggestions to increase causal reality in scenario design.
From muddiness to madness: an examination of decent work and mental health in the Ghanaian mining industry
Authors: Amponsah-Tawiah Kwesi , Mensah Justice , Boakyewaa Ruth , Asare Grace 
Published: April 2023

Purpose
Building on the emerging literature on the psychology of working theory, this study aims to examine the impact of decent work on employees’ mental health as well as the association between the dimensions of decent work on employees’ mental health.

Design/methodology/approach
Quantitative data were collected from 260 employees working in the Ghanaian mining industry.

Findings
Data analysis showed a positive significant relationship between decent work and employee mental health. Furthermore, access to health care, adequate compensation and hours that allow for free time and rest related positively and significantly with employee mental health. However, the relationships between physical and interpersonal safe working conditions, organizational values that complement family and social values and employee mental health were not significant.

Originality/value
The findings extend the emerging literature relative to the influence of decent work on mental health in developing country context, specifically, sub-Saharan Africa where concerns for decent work have become extremely relevant because of the experience of extreme poverty and unemployment that characterize the region.
Assessment of Sustainable Development Goals through Industry 4.0 and reconfigurable manufacturing system practices
Authors: Pansare Rajesh , Yadav Gunjan , Garza-Reyes Jose Arturo , Raosaheb Nagare Madhukar 
Published: April 2023

PurposeThe United Nation's Sustainable Development Goals (SDGs), introduced in 2015, connect several manufacturing strategies and promote sustainable practices in an organization. Manufacturing companies are struggling to meet changing market demands while also addressing social and biological issues. The current study aims to develop a framework that can assist practitioners and managers contribute to the attainment of the SDGs through the adoption of reconfigurable manufacturing system (RMS) practices and Industry 4.0 technologies.Design/methodology/approachAn extensive literature review was carried out to identify RMS-Industry 4.0 practices and their interconnection, as well as their contribution to achieving the SDGs. The stepwise weight assessment ratio analysis (SWARA) method was then used to compute the weights of the selected RMS-Industry 4.0 practices, whereas the weighted aggregated sum product assessment (WASPAS) method was used to prioritize performance metrics. The developed framework's robustness was tested using a sensitivity analysis across five different organizations.FindingsThe findings show that advanced technologies practices have the most importance, followed by customization and rapid adjustment of capacity and functionality practices. The sensitivity analysis revealed the robustness of the developed framework as well as its adaptability among the chosen organizations.Practical implicationsThis research will assist in the adoption of RMS and includes recent technologies that can help in the attainment of industrial SDGs. Managers will also be able to evaluate RMS in the context of industrial SDGs. Researchers and practitioners can now address the various RMS-Industry 4.0 practices while keeping the social and environmental aspects in mind.Originality/valueNo previous research has investigated the SDGs through the nexus effect of Industry 4.0 and RMS practices.
Impact of entrepreneurial leadership on supply chain performance: the mediating role of supply chain resilience
Authors: Haq Muhammad Zia ul , Aslam Haris 
Published: April 2023

PurposeThe purpose of this study is to discern the role of entrepreneurial leadership (EL) – a dynamic capability – in increasing supply chain performance (SCP), through building supply chain resilience (SCR). The study further suggests that the presence of supply chain orientation (SCO) within a firm will enhance the relationship between EL and SCR.Design/methodology/approachDynamic capabilities view is used to develop the hypotheses and a survey method is used to collect data from manufacturing firms in Pakistan. The hypothesized model is tested using structural equation modeling (SEM).FindingsThe results in general confirm the hypothesized model. The findings suggest that SCR mediates the relationship between EL and SCP. The results also confirm that SCO moderates the relationship between EL and SCR.Originality/valueThis paper contributes by studying the pivotal role of EL in building SCR and sustaining a competitive advantage in an uncertain environment.
Performance and microstructural investigations of processed lateritic fine aggregates in blended cement mortars exposed to elevated temperatures
Authors: Basavana Gowda S.N. , Yaragal Subhash , Rajasekaran C. , Goudar Sharan Kumar 
Published: April 2023

PurposeIn recent years, fire accidents in engineering structures have often been reported worldwide, leading to a severe risk to life and property safety. The present study is carried out to evaluate the performance of Ground Granulated Blast Furnace Slag (GGBS) and fly ash–blended laterized mortars at elevated temperatures.Design/methodology/approachThis test program includes the replacement of natural river sand with lateritic fine aggregates (lateritic FA) in terms of 0, 50 and 100%. Also, the ordinary Portland cement (OPC) was replaced with fly ash and GGBS in terms of 10, 20, 30% and 20, 40 and 60%, respectively, for producing blended mortars.FindingsThis paper presents results related to the determination of residual compressive strengths of lateritic fine aggregates-based cement mortars with part replacement of cement by fly ash and GGBS exposed to elevated temperatures. The effect of elevated temperatures on the physical and mechanical properties was evaluated with the help of microstructure studies and the quantification of hydration products.Originality/valueA sustainable cement mortar was produced by replacing natural river sand with lateritic fine aggregates. The thermal strength deterioration features were assessed by exposing the control specimens and lateritic fine aggregates-based cement mortars to elevated temperatures. Changes in the mechanical properties were evaluated through a quantitative microstructure study using scanning electron microscopy (SEM) images. The phase change of hydration products after exposure to elevated temperatures was qualitatively analyzed by greyscale thresholding of SEM images using Image J software.
Transformational leadership and work engagement as mediators on nurses’ job performance in healthcare clinics: work environment as a moderator
Authors: Hasan Amal Abdullah , Ahmad Syed Zamberi , Osman Abdullah 
Published: April 2023

Purpose
This study aims to investigate the mediating effect of transformational leadership (TL) and work engagement (WE) on health-care clinic nurses’ performance and the crucial role of these variables in the work environment (WEV).

Design/methodology/approach
Data were collected from 353 nurses working across various health-care clinics in the United Arab Emirates. This study used descriptive correlational statistics from the Statistical Package for the Social Sciences, the Pearson correlation coefficient, confirmatory factor analysis for model validity, Cronbach’s alpha for reliability and path analysis to determine the results.

Findings
The relationship between TL and job performance among nurses in health-care clinics was strongly influenced by WE. In addition, a moderate WEV increased the positive influence of TL on job accomplishment. Furthermore, there were no statistically significant differences between the participants’ demographics characteristics and the main variables of the study.

Practical implications
Health-care management can support and enhance nurses’ job performance through TL, create a more structured WEV and support WE.

Originality/value
This study involves a specific investigation into WE as a mediator, WEV as a moderator and the effect of TL on nurses’ job performance.
Perceived benefits of modern cooking technologies: a study of beneficiaries of Pradhan Mantri Ujjwala Yojana
Authors: Angoori Sukhvinder , Kumar Sanjeev 
Published: April 2023

PurposeThis paper examine beneficiary women's awareness of the harmful effects of traditional cooking fuels and the benefits of cleaner cooking fuel (LPG) in the Indian state of Haryana after the inception of Pradhan Mantri Ujjwala Yojana.Design/methodology/approachDescriptive statistics, factor analysis, confirmatory factor analysis, Mann–Whitney U test and Kruskal–Wallis H test were used for the data analysis.FindingsThe paper finds that the women of the scheduled caste were highly aware of the hazards of traditional cooking fuel. They perceived that the usage of LPG led to significant health and environmental improvements. However, the refilling was low among the respondents. So, the only low awareness was not the cause of the low refilling of LPG among Ujjwala beneficiaries.Research limitations/implicationsTechnological advancement, accessibility and successful adoption require convergence with socio-economic and institutional aspects. It was evident that focus on technology might not necessarily serve developmental purposes if it is not integrated correctly with socio-economic and institutional factors. These should have conversed with the household's needs, preferences, affordability, social structures, policy support and delivery mechanism, as it was observed that, in different cases, high-end technologies have limited access.Originality/valueThis study shows that the low awareness is not the barrier to the adoption of cleaner cooking technologies in India. So, the policymakers have to revive and further investigate the real cause of the low adoption of cleaner cooking technologies in India.
Developing a metabolic model‐based fed‐batch feeding strategy for Pichia pastoris fermentation through fine‐tuning of the methanol utilization pathway
Authors: Boojari Mohammad Amin , Rajabi Ghaledari Fatemeh , Motamedian Ehsan , Soleimani Mehdi , Shojaosadati Seyed Abbas 
Published: April 2023

AbstractPichia pastoris is a commonly used microbial host for recombinant protein production. It is mostly cultivated in fed‐batch mode, in which the environment of the cell is continuously changing. Hence, it is vital to understand the influence of feeding strategy parameters on the intracellular reaction network to fine‐tune bioreactor performance. This study used dynamic flux balance analysis (DFBA) integrated with transcriptomics data to simulate the recombinant P. pastoris (Muts) growth during the induction phase for three fed‐batch strategies, conducted at constant specific growth rates (μ‐stat). The induction phase was split into equal time intervals, and the correlated reactions with protein yield were identified in the three fed‐batch strategies using the Pearson correlation coefficient. Subsequently, principal component analysis (PCA) was applied to cluster induction phase time intervals and identify the role of correlated reactions on metabolic differentiation of time intervals. It was found that increasing fluxes through the methanol dissimilation pathway increased protein yield. By adding a methanol assimilation pathway inhibitor (HgCl2) to the shake flask medium growing on glycerol: methanol mixture (10%: 90%, v/v), the protein titre increased by 60%. As per DFBA, the higher the methanol to biomass flux ratio (Rmeoh/Δx), the higher the protein yield. Finally, a novel feeding strategy was developed to increase the amount of Rmeoh/Δx compared to the three feeding strategies. The concentration of recombinant human growth hormone (rhGH), used as the model protein, increased by 16% compared to the optimal culture result obtained previously (800 mg L−1 to 928 mg L−1), while production yield improved by 85% (24.8 mg gDCW−1 to 46 mg gDCW−1).
Pretreatment absolute lymphocyte count is an independent predictor for survival outcomes for esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiotherapy and pembrolizumab: An analysis from a prospective cohort
Authors: Qi Wei‐Xiang , Wang Xiaoyan , Li Chengqiang , Li Shuyan , Li Huan , Xu Feifei , Chen Jiayi , Zhao Shengguang , Li Hecheng 
Published: April 2023

AbstractBackgroundThe aim of the study was to analyze the relationship between pretreatment inflammatory biomarkers (IBs) and survival outcomes for patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (neo‐CRT) and pembrolizumab.MethodsClinical variables and IBs (absolute monocyte count [AMC], absolute lymphocyte count [ALC], platelet count [PLT], neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte ratio [PLR], lymphocyte‐to‐monocyte ratio [LMR], pan‐immune inflammation value [PIV], systemic immunoinflammatory index [SII], systemic immunoreactivity index [SIRI] and prognostic nutritional index [PNI]) were collected. Univariate and multivariate analysis were performed to identify the independent factors for outcomes of ESCC.ResultsA total of 51 patients were included. Of these, 35 patients achieved pathological complete response (pCR) after neo‐CRT and pembrolizumab (pCR: 68.6%). With a median follow‐up of 20 months, the two‐year PFS and OS of the cohort was 64% and 91%, respectively. Multivariate logistic regression analysis indicated that ALC (overall response [OR] 4.4, p = 0.051) and PLT (OR 6.7, p = 0.023) were two independent predictors for achieving pCR among ESCC treated with neo‐CRT and pembrolizumab. Multivariate Cox regression analysis showed that ALC (HR 0.27, p = 0.028) and SIRI (HR 3.13, p = 0.048) were two independent predictors associated with PFS. Kaplan Meier analysis demonstrated that the PFS of ESCC with high baseline ALC was significantly better than those with low ALC (2‐year PFS: 77% vs. 47%, p = 0.027), but not for overall survival (2‐year OS: 96% vs. 87%, p = 0.46).ConclusionsThis retrospective analysis based on a prospective cohort for the first time demonstrates that pretreatment ALC is an independent predictor for achieving pCR and favorable outcomes of ESCC treated with neo‐CRT and pembrolizumab.
Editorial: safety of topical steroids designed specifically for eosinophilic oesophagitis – new data bring new questions. Authors' reply
Authors: Hirano Ikuo , Dellon Evan S. , Gupta Sandeep K. , Katzka David A. , Collins Margaret H. , Wojtowicz Abigail M. , Terreri Brian , Zhang Wenwen , Boules Mena , Bhatia Siddharth , Desai Nirav K. 
Published: April 2023

LINKED CONTENTThis article is linked to Hirano et al papers. To view these articles, visit https://doi.org/10.1111/apt.17430 and https://doi.org/10.1111/apt.17442.
Letter: Does irritable bowel syndrome have a greater impact in Western, compared with Asian, patients?
Authors: Chuah Kee‐Huat , Mahadeva Sanjiv 
Published: April 2023

LINKED CONTENTThis article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.17356 and https://doi.org/10.1111/apt.17497.
Real‐world outcomes of switching from adalimumab originator to adalimumab biosimilar in patients with inflammatory bowel disease: The ADA‐SWITCH study
Authors: Casanova María José , Nantes Óscar , Varela Pilar , Vela‐González Milagros , Rivero Montserrat , Sierra‐Gabarda Olivia , Riestra Sabino , Barreiro‐de Acosta Manuel , Martín‐Rodríguez María del Mar , Gargallo‐Puyuelo Carla Jerusalén , Reygosa Cristina , Muñoz Roser , de la Filia‐Molina Irene García , Núñez‐Ortiz Andrea , Kolle Lilyan , Calafat Margalida , Huguet José María , Iglesias‐Flores Eva , Martínez‐Pérez Teresa de Jesús , Bosch Orencio , Duque‐Alcorta José María , Frago‐Larramona Santiago , Van Domselaar Manuel , González‐Cosano Víctor Manuel , Bujanda Luis , Rubio Saioa , Mancebo Alejo , Castro Beatriz , García‐López Santiago , de Francisco Ruth , Nieto‐García Laura , Laredo Viviana , Gutiérrez‐Casbas Ana , Mesonero Francisco , Leo‐Carnerero Eduardo , Cañete Fiorella , Ruiz Lucía , Gros Beatriz , del Moral‐Martínez María , Rodríguez Cristina , Chaparro María , Gisbert Javier P. 
Published: April 2023

SummaryBackground and AimsData on the outcomes after switching from adalimumab (ADA) originator to ADA biosimilar are limited. The aim was to compare the treatment persistence, clinical efficacy, and safety outcomes in inflammatory bowel disease patients who maintained ADA originator vs. those who switched to ADA biosimilar.MethodsPatients receiving ADA originator who were in clinical remission at standard dose of ADA originator were included. Patients who maintained ADA originator formed the non‐switch cohort (NSC), and those who switched to different ADA biosimilars constituted the switch cohort (SC). Clinical remission was defined as a Harvey–Bradshaw index ≤4 in Crohn's disease and a partial Mayo score ≤2 in ulcerative colitis. To control possible confounding effects on treatment discontinuation, an inverse probability treatment weighted proportional hazard Cox regression was performed.ResultsFive hundred and twenty‐four patients were included: 211 in the SC and 313 in the NSC. The median follow‐up was 13 months in the SC and 24 months in the NSC (p < 0.001). The incidence rate of ADA discontinuation was 8% and 7% per patient‐year in the SC and in the NSC, respectively (p > 0.05). In the multivariate analysis, switching from ADA originator to ADA biosimilar was not associated with therapy discontinuation. The incidence rate of relapse was 8% per patient‐year in the SC and 6% per patient‐year in the NSC (p > 0.05). Six percent of the patients had adverse events in the SC vs. 5% in the NSC (p > 0.05).ConclusionSwitching to ADA biosimilar did not impair patients' outcomes in comparison with maintaining on the originator.
Early diagnosis of subclinical left ventricular dysfunction in postmenopausal women with rheumatoid arthritis
Authors: Maiello Maria , Cecere Annagrazia , Ciccone Marco M. , Palmiero Pasquale 
Published: April 2023

AbstractObjectiveHeart failure is the most frequent cause of death among patients affected by rheumatoid arthritis(RA), in which high prevalence is independent of traditional risk factors. An early diagnosis of subclinical heart failure may be made by assessing left ventricular diastolic dysfunction (LVDD) by Doppler Echocardiography. Our study aims to early identify LVDD in RA patients.MethodsWe enrolled 207 consecutive postmenopausal women (PMW) with normal electrocardiography and physical examination with a confirmed diagnosis of RA, for over one year, 200 PMW free from RA served as the control group (CG). All women underwent M‐mode and two‐dimensional Doppler echocardiography.ResultsA total of 72 women were affected by LVDD among 207 women with RA (34.8%), 46 among 200 women in the CG (23%), chi‐squared 6.8, OR 1.8, confidence interval (CI) 95%, p < 0.009. For our RA women, the chance of being affected by LVDD has almost doubled. There were 70 women affected by LVDD among 72 hypertensive women with RA (97.2%). A total of 32 women were affected by LVDD among 98 hypertensive women in the CG (32.7%), chi‐squared 72.1, OR 7.2, CI 95%, p < 0.009. Among hypertensive PMW in our population, the chance of being affected by LVDD has more than tripled. All LVDD subjects had abnormal diastolic function for all different degrees.ConclusionWe propose that PMW, affected by RA, have a significantly higher prevalence than CG of LVDD without clinical evidence of heart disease. Since the prevalence is even higher if they are hypertensive, we suggest a Doppler echocardiography examination for all women with a diagnosis of RA.
Impact of the COVID‐19 pandemic on exercise tolerance and patient outcomes with Phase III cardiac rehabilitation in Japan: A multicenter study
Authors: Kitayama Tatsuro , Mikami Kenta , Usui Naoto , Emori Ryo , Tsuji Taishi , Maruyama Yasuyuki , Harada Tadanori 
Published: April 2023

AbstractThis study aimed to determine how behavioural restrictions due to the emergency declaration following the coronavirus disease 2019 (COVID‐19) pandemic affect exercise tolerance and its outcomes in patients in Phase III cardiac rehabilitation programme. This is a multicenter retrospective cohort study. Participants in outpatient cardiac rehabilitation programmes and cardiopulmonary exercise testing before and after the emergency declarations were included. A total of 90 participants were included (median age 75.0 years, 69% male), and the changes in physical function and exercise tolerance were compared before and after the emergency declaration. Patients were divided into a decline‐in‐peak oxygen uptake (VO2) group and a nondecline‐in‐peak VO2 group. Comparison before and after the emergency declaration showed that the anaerobic threshold declined significantly and peak VO2 exhibited a downward trend. The decline‐in‐peak VO2 group consisted of 16 patients (17%) with better exercise tolerance, multiple comorbidities, and declined lower extremity muscle strength. These patients also had a higher rate of subsequent composite events (hazard ratio, 5.2; 95% confidence interval, 1.4–18.8, p = 0.01). Before and after the emergency declaration, the patient's exercise tolerance may decline, leading to a poor prognosis. This study suggests the importance of maintaining exercise tolerance during the COVID‐19 pandemic.