bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Feedback and Risk‐Taking: A Configurational Approach
Authors: Goyal Lakshmi , Popli Manish 
Published: August 2023

AbstractBased on the notion that organizations are complex systems, this study combines the configurational perspective with the performance feedback theory to explore constellations of multi‐level causal conditions that explain variations in firm risk‐taking behaviour. Using the fuzzy set methodology as our analytic approach, we derive multiple configurations based on a dataset of 1753 observations belonging to 402 firms from the US pharmaceutical industry. Our findings espouse equifinality and the differential importance of factors denoting a firm's ability, motivation and opportunity space in determining low and high levels of risk‐taking. Across historical and social aspirations, our results disclose significant differences and similarities in constellations of causal conditions leading to high and low levels of risk‐taking, respectively. Our findings contribute to the behavioural theory of the firm and have important implications for managerial practice.
Suicide of an adolescent girl with sodium nitrite ordered on the internet
Authors: Loiseau Mélanie , Matheux Alice , Sabini Sandrine , Cavard Stéphanie , Advenier Anne‐Sophie , Pasquet Agathe , François‐Purssell Irène , Guerard Pascal 
Published: August 2023

AbstractNitrites are commonly used in the chemical, pharmaceutical, and food industries. Recently, they have been identified in cases of voluntary intoxication. We report the case of a 13‐year‐old girl who was found lifeless on her bed next to a glass containing a white powder and a bottle containing a white powder with a moistened appearance. External examination and autopsy revealed a nonspecific asphyxia syndrome, which was confirmed by the pathological analysis. Analysis of the samples revealed metoclopramide in the peripheral blood at a concentration of 0.402 mg/L (LC–HRMS). An analysis of the gastric contents was carried out after sodium nitrite was detected in the powders found near the body (Raman spectrometry). Nitrites were found in the gastric fluid at a concentration of 30.9 mg/L. Death occurred secondary to anoxia, following ingestion of nitrites; suicide kits are available on the web and nitrites are relatively easy to source and inexpensive. Nitrites are delivered in powder form to be dissolved in liquid, which may then be consumed with metoclopramide (or an alternative anti‐emetic drug) to maximize absorption and reduce emesis. The toxic effect of nitrites lies in their oxidizing power, causing the transformation of hemoglobin into methemoglobin, which, when it accumulates, induces tissue anoxia resulting in death. There has been an alarming increase in the number of cases linked to suicide using nitrites or a nitrite suicide kit. The fact that nitrites are readily available online underscores the importance of establishing effective preventive measures such as limiting the access and use of this chemical.
The validity of self‐rated alcohol susceptibility in predicting alcohol use in early adolescents in Latin America
Authors: Dramis Agustín , Mejía Raúl , Thrasher James F. , Barrientos‐Gutiérrez Inti , Sargent James , Pérez Adriana 
Published: August 2023

AbstractBackgroundThe measurement of substance use susceptibility was first conceived as part of the preparatory stage that precedes youth smoking initiation and is defined as the lack of a firm commitment not to smoke in the future. Despite being a consistent and validated predictor of smoking initiation, there has been little research on whether susceptibility can predict alcohol use. This study assessed the validity of an adapted alcohol susceptibility measure to predict alcohol consumption among early adolescent students in Argentina and Mexico who had not previously consumed alcohol.MethodsA school‐based longitudinal study was conducted among first‐year students in 33 secondary schools in Argentina and 57 in Mexico. The baseline sample included 1504 never‐drinker adolescents in Argentina and 5264 in Mexico, of whom 1055 and 3540, respectively, completed a follow‐up survey one and a half years later. Logistic regression with school as a random effect was used to estimate the adjusted odds ratios for the transitions from never‐drinker to ever‐drinker, current drinker, and binge drinker.ResultsAt baseline, 34% and 23.6% of adolescent never‐users in Argentina and Mexico, respectively, were susceptible to alcohol. After controlling for other known predictors of alcohol use initiation, alcohol susceptibility was positively associated with ever‐drinking (OR = 3.23, 95% CI 2.38–4.36 in Argentina, OR = 1.73, 95% CI 1.43–2.10 in Mexico), current drinking (OR = 2.41, 95% CI 1.71–3.4 in Argentina, OR = 1.77, 95% CI 1.37–2.28 in Mexico), and binge drinking (OR = 2.27, 95% CI 1.78–2.91 in Argentina, OR = 1.89, 95% CI 1.32–1.99 in Mexico).ConclusionsThe susceptibility measure adapted for use with alcohol appears valid for identifying individuals or groups at risk of drinking initiation and problematic drinking among early adolescents in Argentina and Mexico.
Moving away from chemotherapy in newly diagnosed Philadelphia chromosome‐positive B‐cell acute lymphoblastic leukaemia
Authors: Haddad Fadi G. , Kourie Hampig Raphael , Saleh Khalil 
Published: August 2023

Chemotherapy‐free regimens are reshaping the treatment landscape of Philadelphia chromosome‐positive acute lymphoblastic leukaemia. The report by Xie et al. suggests that the combination of dasatinib and prednisone is effective as induction and early consolidation. Survival was improved in patients who subsequently underwent allogeneic stem cell transplantation.Commentary on: Xie et al. Dasatinib plus prednisone as induction and consolidation for adults with Ph‐positive acute lymphoblastic leukaemia: A single‐arm, multicentre, phase 2 trial. Br J Haematol 2023;202:1119–1126.
Application and evolution of design in oral health: A systematic mapping study with an interactive evidence map
Authors: Leason Isobel , Longridge Nicholas , Nickpour Farnaz 
Published: August 2023

AbstractObjectivesThere is increasing recognition of the value and capabilities of design in healthcare. Beyond the development of medical devices, design is increasingly being applied to intangible, complex and systemic healthcare problems. However, there is limited evidence on the use of design specifically in the field of oral health. This systematic mapping study aims to collate and catalogue evidence of design in oral health.MethodsA systematic search of academic databases and grey literature was performed. Duplicate results were removed, and publications relating to the same project were grouped. Reviewers from design and oral health independently screened a sample of the dataset. Projects of both relevance to oral health, and with input from a designer or clear implementation of a design methodology or approach were included. Projects were coded and plotted on a novel interactive evidence map.Results119 design and oral health projects were included between 1973 and 2022. Interventional (n = 94, 79%), empirical (n = 46, 39%), methodological (n = 35, 29%) and theoretical (n = 7, 6%) design contributions were identified across the projects. The projects were categorized by four orders of design: first—graphics (n = 6, 5%), second—products (n = 41, 34%), third—interactions (n = 70, 59%), and fourth—systems (n = 2, 2%). Design was found in a diverse range of contexts in oral health; most commonly being relevant to general patients (n = 61, 51%), and for use in general dental practice (n = 56, 47%). Further design outcome categories (digital material; printed material; object; room or space; apparel; process; smart device; tangible interface; graphical interface; virtual reality; service; policy; system) and oral health themes (oral health literacy; oral care training; dental clinic design; dental instruments and equipment; personal oral care; dental appliance; clinician health and productivity; clinical information systems; informed consent; oral health promotion and prevention; oral care training; patient interactions and experience) were identified.ConclusionsThe novel interactive evidence map of design in oral health created enables ongoing and open‐ended multivariant documentation and analysis of the evidence, as well as identification of strategic opportunities. Future research and policy implications include; recognition and engagement with the full capabilities of design; integration of design experts; fostering inclusive engagement and collaboration; disentangling patient and public involvement; advancing human‐centred systems approaches; adopting design‐led approaches for policy‐making.
Genetic findings in Czech patients with limb girdle muscular dystrophy
Authors: Zídková Jana , Kramářová Tereza , Kopčilová Johana , Réblová Kamila , Haberlová Jana , Mazanec Radim , Voháňka Stanislav , Gřegořová Andrea , Langová Martina , Honzík Tomáš , Šoukalová Jana , Ošlejšková Hana , Solařová Pavla , Vyhnálková Emílie , Fajkusová Lenka 
Published: August 2023

AbstractLimb girdle muscular dystrophies (LGMD) are a genetically heterogeneous group of muscular dystrophies. The study presents an overview of molecular characteristics of a large cohort of LGMD patients who are representative of the Czech LGMD population. We present 226 LGMD probands in which 433 mutant alleles carrying 157 different variants with a supposed pathogenic effect were identified. Fifty‐four variants have been described only in the Czech LGMD population so far. LGMD R1 caplain3‐related is the most frequent subtype of LGMD involving 53.1% of patients with genetically confirmed LGMD, followed by LGMD R9 FKRP‐related (11.1%), and LGMD R12 anoctamin5‐related (7.1%). If we consider identified variants, then all but five were small‐scale variants. One large gene deletion was identified in the LAMA2 gene and two deletions in each of CAPN3 and SGCG. We performed comparison our result with other published studies. The results obtained in the Czech LGMD population clearly differ from the outcome of other LGMD populations in two aspects—we have a more significant proportion of patients with LGMD R1 calpain3‐related and a smaller proportion of LGMD R2 dysferlin‐related.
Laparoscopic versus ultrasound‐guided transversus abdominis plane block in colorectal surgery: a non‐inferiority, multicentric randomized double‐blinded clinical trial
Authors: La Regina Davide , Popeskou Sotirios Georgios , Saporito Andrea , Gaffuri Paolo , Tasciotti Edoardo , Dossi Roberto , Christoforidis Dimitri , Mongelli Francesco 
Published: August 2023

AbstractAimThe aim of this study was to assess if laparoscopic‐assisted transversus abdominis plane (TAP) block (L‐TAPB) is as efficient as ultrasound‐guided TAP block (U‐TAPB) in postoperative pain control.MethodIn all, 112 patients scheduled for elective laparoscopic colon resection from February 2018 to December 2021 at two Swiss hospitals were included and randomized in a 1:1 ratio before surgery with either L‐TAPB or U‐TAPB. The primary end‐point was the non‐inferiority of the L‐TAPB compared to U‐TAPB with regard to the total opioid consumption within the first 24 h after surgery. Data regarding patients' characteristics, opioid consumption, pain on the visual analogue scale, operative and anaesthesia induction time, complications and length of stay were collected and analysed.ResultsFifty‐five patients were allocated to the L‐TAPB and fifty‐seven to the U‐TAPB. No significant difference was found in the overall dose of opioids within 24 h, and the non‐inferiority of the L‐TAPB was confirmed. There were almost twice as many patients in the L‐TAPB group requesting opioid reserves compared to the U‐TAPB group (54.5% vs. 29.8%, P = 0.008). The anaesthesia induction time was significantly longer in the U‐TAPB group (17 ± 11 min vs. 23 ± 12 min, P = 0.014). For all other variables (pain on the visual analogue scale, opioid consumption, need of epidural analgesia, operating time, postoperative complications and hospital stay) no statistically significant difference between the L‐TAPB and the U‐TAPB groups was noted.ConclusionOur results showed the non‐inferiority of the laparoscopic delivery compared to ultrasound‐guided administration of the TAP block, with the advantage of not affecting anaesthesia times.Study registration number2017‐02017 CE 3294, ClinicalTrials.gov identifier NCT04575233.
Home noninvasive ventilation use in patients hospitalized with COPD
Authors: Fortis Spyridon , Gao Yubo , Rewerts Kelby , Sarrazin Mary Vaughan , Kaboli Peter J. 
Published: August 2023

AbstractIntroductionThe study objective was to estimate the prevalence of chronic hypercapnic respiratory failure (CHRF) and home noninvasive ventilation (NIV) use in a high‐risk population, individuals with a history of at least one COPD‐related hospitalizations.MethodsWe retrospectively analyzed electronic medical record data of patients with at least one COPD‐related hospitalization between October 1, 2011, and September 30, 2017, to the Iowa City VA Medical Center. We excluded individuals with no obstructive ventilatory defect.ResultsOf 186 patients, the overall prevalence of compensated hypercapnic respiratory failure (CompHRF), defined as PaCO2 > 45 mmHg with a pH = 7.35–7.45, was 52.7%, while the overall prevalence of home NIV was 4.3%. The prevalence of CompHRF was 43.6% and home NIV was 1.8% in those with one COPD‐related hospitalization. Among those with ≥4 COPD‐related hospitalizations, the prevalence of CompHRF was 77.8% (14 of 18), and home NIV was 11.1% (2 of 18).ConclusionApproximately half of individuals with at least one COPD‐related hospitalization have CompHRF, but only 8.2% of those use home NIV. Future studies should estimate CHRF rates and the degree of underutilization of home NIV in larger multicenter samples.
Mycophenolic acid therapeutic drug monitoring using area under the curve in pediatric heart transplant recipients
Authors: Newland David M. , Pak Jennifer L. , Ali Reda , Herzog Thiebaut , Nemeth Thomas L. , Tressel William , Kronmal Richard A. , Knorr Lisa R. , Albers Erin L. , Friedland‐Little Joshua M. , Ahmed Humera , Kemna Mariska S. , Hong Borah J. , Spencer Kathryn , Law Yuk M. 
Published: August 2023

AbstractIntroductionPharmacokinetics of mycophenolic acid (MPA) display substantial interpatient variability, with up to 10‐fold difference of exposure in individual patients under a fixed‐dose regimen. MPA trough level (C0) monitoring is common in clinical practice but has not proven sufficiently informative in predicting MPA exposure or patient outcomes, especially in children. No limited sampling strategies (LSSs) have been generated from pediatric heart transplant (HTx) recipients to estimate MPA AUC.MethodsSingle‐center, observational analysis of 135 de novo pediatric HTx recipients ≤21 years old who underwent MPA AUC between 2011 and 2021.ResultsMedian age was 4 years (IQR .6–12.1). Median time from transplant to MPA AUC sampling was 15 days (IQR 11–19). MMF doses (mg or mg/day) had low, negative Pearson correlation coefficients (r) while doses adjusted for weight or body surface area had low correlation with Trapezoidal MPA AUC0–24 h (r = .3 and .383, respectively). MPA C0 had weak association (r = .451) with Trapezoidal MPA AUC0–24 h. LSS with two pharmacokinetic sampling time points at 90 (C3) and 360 (C5) min after MMF administration (estimated AUC0–24 h = 32.82 + 4.12 × C3 + 11.53 × C5) showed strong correlation with Trapezoidal MPA AUC0–24 h (r = .87).ConclusionMMF at fixed or weight‐adjusted doses, as well as MPA trough levels, correlate poorly with MPA AUC0–24 h. We developed novel LSSs to estimate Trapezoidal MPA AUC from a large cohort of pediatric HTx recipients. Validation of our LSSs should be completed in a separate cohort of pediatric HTx recipients.
French pronunciation instruction using the PACE model
Authors: Rose Céline , McBride Adam F. 
Published: August 2023

AbstractAs an overwhelming amount of research has demonstrated that educator preparation programs do not adequately prepare instructors to teach pronunciation, this study aims to help teachers of foreign languages to implement and improve pronunciation instruction (PI) in their classroom by adapting PACE (Presentation, Attention, Co‐construction, and Extension), the commonly used model for grammar instruction. The present study explores the efficacy of this model in improving learners' ability (1) to associate target phonemes with the appropriate phonological context and (2) to produce target phonemes distinctly in a spontaneous speech task. Data suggest that a modified PACE model for PI can be effective in both intermediate‐ and advanced‐level courses. The possibility of adapting an existing and well‐known method for teaching grammar would allow teachers to implement and/or improve their PI with minimal additional training.
Gender, risk, and presentation of self in “caring” prison work: Insights from institutional parole officers in Canada
Authors: Norman Mark , Ricciardelli Rosemary , Maier Katharina 
Published: August 2023

AbstractWhile scholars have investigated how prison workers understand and navigate occupational risks through performances of gender, most studies have focused on staff in security roles whose organizational cultures value displays of masculinities premised on characteristics such as toughness and stoicism. Less scholarly attention has considered how prison staff in nonsecurity roles, who perform duties oriented toward using interpersonal skills and helping others—characteristics that are commonly associated with female‐dominated helping professions—understand and navigate risk through gendered forms of impression management. The current study explores the question of how one such occupational group, institutional parole officers (IPOs) working in Canadian federal prisons, performs gender in response to both their perceptions of workplace risk and their occupational, and often personal, commitment to supporting the rehabilitation of prisoners. We organize and analyze our findings using Goffman's (1959) theory of impression management to demonstrate that IPOs, as they attempt to both support prisoners and mitigate the perceived risks of a prison workplace, perform gendered presentations of self that fluidly incorporate aspects of masculinities and femininities. However, we also argue that female IPOs experience greater feelings of workplace vulnerabilities and, thus, perform more impression management labor than their male counterparts. Our analysis thus deepens the limited literature on gendered presentations of self among nonsecurity prison workers by situating gender performances within the occupational risks experienced in the prison workplace.
Internet and social media preferences of orthopaedic patients vary according to factors such as age and education levels
Authors: Gencer Batuhan , Doğan Özgür , Çulcu Ahmet , Ülgen Nuri Koray , Çamoğlu Can , Arslan Mehmet Murat , Mert Orhan , Yiğit Alperen , Yeni Teoman Bekir , Hanege Furkan , Gencer Elif Nur , Biçimoğlu Ali 
Published: August 2023

AbstractBackgroundPatients can often access the internet and social media for health information but it is not clear how much they trust and use the information retrieved.ObjectiveTo investigate the social media and internet use rates and preferences of orthopaedic patients, to reveal to what extent they self‐treat, and to probe the affecting factors.MethodsTwo thousand fifty‐eight patients admitted to an orthopaedic polyclinic were asked to fill out a survey (voluntarily) consisting of 15 items, to collect demographic data, preference for platforms and sources used, trusted sources, and the extent to which information obtained was used for self‐care.ResultsThe most preferred and most trusted sources of information were Google and other search engines, and physicians' personal websites (p < 0.001).DiscussionVariables such as age, gender, educational level and occupation affect the research preferences. Reliance on social media decreases with increasing educational levels (p < 0.001).ConclusionHealth information and knowledge services should work with health professionals to improve aspects of health literacy among orthopaedic patients.
Effects of topic familiarity on L2 writing processes and behaviors
Authors: Li Shaopeng , Yu Hanjing 
Published: August 2023

AbstractThe present study aims to investigate how topic familiarity influences the writing processes and behaviors of 57 Chinese English as a foreign language learners. The quantitative keystroke logging data sketched out participants’ general writing processes and behaviors. Additionally, two focal writers from different writing tasks were interviewed using a post‐task stimulated recall method, and the qualitative data from their comments together with their writing process graphs supported by Inputlog8.0 were analyzed to complement the quantitative results. Results showed that writing on a less familiar topic resulted in longer planning time, shorter texts, slower writing pace, and less revision compared to writing on a more familiar topic. Data analysis confirmed the role of topic familiarity in determining the allocation of time among L2 writing sub‐processes and patterns of L2 writers’ writing behaviors.
Nutritional quality and bioactive compounds of arugula (Eruca sativa L.) sprouts and microgreens
Authors: Komeroski Marina Rocha , Portal Keyla Araujo , Comiotto Jorgiana , Klug Tâmmila Venzke , Flores Simone Hickmann , Rios Alessandro de Oliveira 
Published: August 2023

SummaryAs an alternative to vegetables in their traditional stages of maturation, sprouts, and microgreens are increasing in popularity mainly due to the potential health benefit of the contents of bioactive compounds. This work aimed to evaluate and compare the nutritional profile and the bioactive compounds of arugula (Eruca sativa L.) sprouts and microgreens produced organically in a hydroponic system. Seeds were placed in phenolic foams and soaked in water for 48 h to promote germination according to the supplier's recommendation. Sown trays were placed on top of perforated polystyrene boards and irrigated using a nutrient solution. Seeded trays were kept in a controlled environment and were exposed to 12 h photoperiod. Sprouts were harvested after 7 days of germination, while the microgreens were harvested after 14. As a result, these vegetables showed a high protein content, with sprouts being statistically different from microgreens (24.8% sprouts; 18.2% microgreens), with an excellent content of total fibre (34.3% sprouts; 28.7% microgreens) and soluble fibre (11.5% sprouts; 6.7% microgreens). Regarding the bioactive compounds, the predominance of carotenoids zeaxanthin and β‐carotene in the sprouts (41.8 and 19.8 μg g−1, respectively) and the identification of more compounds as O‐glucosides derived from flavonoids in the microgreens were noted.