bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian optimisation for breeding schemes
Authors: Diot Julien , Iwata Hiroyoshi 
Published: January 2023

IntroductionAdvances in genotyping technologies have provided breeders with access to the genotypic values of several thousand genetic markers in their breeding materials. Combined with phenotypic data, this information facilitates genomic selection. Although genomic selection can benefit breeders, it does not guarantee efficient genetic improvement. Indeed, multiple components of breeding schemes may affect the efficiency of genetic improvement and controlling all components may not be possible. In this study, we propose a new application of Bayesian optimisation for optimizing breeding schemes under specific constraints using computer simulation.MethodsBreeding schemes are simulated according to nine different parameters. Five of those parameters are considered constraints, and 4 can be optimised. Two optimisation methods are used to optimise those parameters, Bayesian optimisation and random optimisation.ResultsThe results show that Bayesian optimisation indeed finds breeding scheme parametrisations that provide good breeding improvement with regard to the entire parameter space and outperforms random optimisation. Moreover, the results also show that the optimised parameter distributions differ according to breeder constraints.DiscussionThis study is one of the first to apply Bayesian optimisation to the design of breeding schemes while considering constraints. The presented approach has some limitations and should be considered as a first proof of concept that demonstrates the potential of Bayesian optimisation when applied to breeding schemes. Determining a general "rule of thumb" for breeding optimisation may be difficult and considering the specific constraints of each breeding campaign is important for finding an optimal breeding scheme.
Identification of major QTLs for soybean seed size and seed weight traits using a RIL population in different environments
Authors: Luo Shilin , Jia Jia , Liu Riqian , Wei Ruqian , Guo Zhibin , Cai Zhandong , Chen Bo , Liang Fuwei , Xia Qiuju , Nian Hai , Cheng Yanbo 
Published: January 2023

IntroductionThe seed weight of soybean [Glycine max (L.) Merr.] is one of the major traits that determine soybean yield and is closely related to seed size. However, the genetic basis of the synergistic regulation of traits related to soybean yield is unclear.MethodsTo understand the molecular genetic basis for the formation of soybean yield traits, the present study focused on QTLs mapping for seed size and weight traits in different environments and target genes mining.ResultsA total of 85 QTLs associated with seed size and weight traits were identified using a recombinant inbred line (RIL) population developed from Guizao1×B13 (GB13). We also detected 18 environmentally stable QTLs. Of these, qSL-3-1 was a novel QTL with a stable main effect associated with seed length. It was detected in all environments, three of which explained more than 10% of phenotypic variance (PV), with a maximum of 15.91%. In addition, qSW-20-3 was a novel QTL with a stable main effect associated with seed width, which was identified in four environments. And the amount of phenotypic variance explained (PVE) varied from 9.22 to 21.93%. Five QTL clusters associated with both seed size and seed weight were summarized by QTL cluster identification. Fifteen candidate genes that may be involved in regulating soybean seed size and weight were also screened based on gene function annotation and GO enrichment analysis.DiscussionThe results provide a biologically basic reference for understanding the formation of soybean seed size and weight traits.
Factors predicting secondary school language course enrollment and performance among U.S. heritage speakers of Spanish
Authors: Nguyen My V. H. , Serafini Ellen J. , Leeman Jennifer , Winsler Adam 
Published: January 2023

IntroductionWhile a growing body of research indicates that Spanish language courses can promote Spanish maintenance and lead to overall improved educational outcomes among heritage speakers, there is little empirical or longitudinal evidence of factors that shape their enrollment in Spanish language courses at the secondary level. To address this issue, the current study takes a large-scale, longitudinal approach to investigate rates of enrollment in secondary school (6th–12th grade) Spanish and other non-English language courses, as well as factors that predict heritage speakers’ enrollment and performance in non-English language courses.MethodWe analyzed subsample data from the Miami School Readiness Project (MSRP), a large-scale, longitudinal study consisting of 17,341 heritage speakers of Spanish (47% female, 95.4% Hispanic/Latino, 82.8% received free/reduced-price lunch, and 18.3% with a disability) who were followed from 4 years old until the end of high school.ResultsIn general, Heritage speakers enrolled in Spanish language courses at a higher rate than other non-English language courses (52.2 and 25.3%, respectively). Enrollment patterns varied across different type of languages and grade level. Student-level factors including disability status, poverty status, early behavioral problems, and prior academic achievement significantly predicted students’ enrollment in Spanish and performance in non-English language courses.DiscussionFindings shed light on the long-term patterns of language study of this growing segment of the US school population with implications for future research and school policies that seek to improve heritage language learning and maintenance as well as equitable access to language education for language-minority students.
Desynchronized white matter function and structure in drug-naive first-episode major depressive disorder patients
Authors: Guo Qinger , Duan Jingfeng , Cai Shuyang , Zhang Jiaxi , Chen Tao , Yang Hong 
Published: January 2023

BackgroundMajor depressive disorder (MDD) is a highly prevalent mental disease. Using magnetic resonance imaging (MRI), although numerous studies have revealed the alterations in structure and function of grey matter (GM), few studies focused on the synchronization of white matter (WM) structure and function in MDD. The aim of this study was to investigate whether functional and structural abnormalities of WM play an essential role in the neurobiological mechanisms of MDD.MethodsGradient-echo imaging sequences at 3.0T were used to gather resting state functional MRI (rsfMRI) data, which were performed on 33 drug-naive first-episode MDD patients and 34 healthy controls (HCs). After data preprocessed, amplitude of low frequency fluctuation (ALFF) of WM was calculated. ALFF values in different frequency bands were analyzed, including typical (0.01–0.15 Hz) band, slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands. In addition, the fractional anisotropy (FA) values in WM in 23 patients and 26 HCs were examined using tract-based spatial statistics (TBSS) and tractography based on diffusion tensor imaging (DTI). Pearson correlation analysis was applied to analyze the relationships between ALFF values and Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA).ResultsCompared with the HCs, MDD patients showed decreased ALFF values in posterior thalamic radiation (PTR) and superior longitudinal fasciculus (SLF) in slow-5 frequency band, no significant differences of ALFF values were found in typical and slow-4 frequency bands. In addition, there were no significant differences in FA values with TBSS analysis as well as the number of fibers in PTR and SLF with tractography analysis between two groups. Further correlation analysis showed that the ALFF value in SLF was negatively correlated with HAMA-2 score (r = −0.548, pFDR = 0.037) in patients.ConclusionOur results indicated that WM dysfunction may be associated with the pathophysiological mechanism of depression. Our study also suggested that the functional damage of the WM may precedes the structural damage in first-episode MDD patients. Furthermore, for mental disorders, slow-5 frequency band may be a more sensitive functional indicator for early detection of abnormal spontaneous brain activity in WM.
Externalities, scarcity, and abundance
Authors: Frischmann Brett M. , Ramello Giovanni B. 
Published: January 2023

IntroductionDo externalities work and matter differently in a world of scarcity vs. a world of abundance? In this article, we critically examine the economic phenomena of externalities. The concept of externality, an important idea in economics and law, is useful in exploring the complex and dynamic relationships between resource supply and human flourishing within various sociotechnical systems.MethodsFirst, we define the basic concept and explain why it is fundamental to economic analysis of complex social environments Second, we briefly survey the intellectual history of externalities with the goal of tying together a few different strands of economic theory and providing a roadmap for a general theory of externalities. This discussion highlights a latent conflict between those who pursue and those who resist perfectibility (optimization) of social systems by internalizing externalities. Third, we compare externalities in worlds of scarcity and abundance.ResultsThis article develops the theoretical framework, including a brief intellectual history and notes toward the development of a general theory of externalities. As a conceptual tool, externalities enable one to identify and examine social interdependencies and to map their causes and consequences. Externalities provide evidence of social demand for governance institutions. This descriptive utility can and should inform normative analysis, the design of governance institutions, and comparative institutional analysis. We also raise a series of (mostly empirical) questions that should frame comparative institutional analysis and evaluation of different externalities in the digital networked world.DiscussionWe focus on the scarcity and abundance of knowledge resources and the (technological) means for participating in the production, dissemination, and modification of such resources. In the real, necessarily imperfect world where abundance and scarcity vary across resources, people, and contexts, externalities persist, indicate social demand for governance, and inform comparative analysis and design of governance institutions.JEL classificationD62, B52, D02.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignant tumors in children: Initial experience in a single institution
Authors: Zhu Zhiyun , Chang Xiaofeng , Wang Jiarong , Yang Shen , Qin Hong , Yang Wei , Cheng Haiyan , Meng Deguang , Wang Huanmin 
Published: January 2023

BackgroundPeritoneal malignant tumors in children are rare but commonly associated with disease progression and poor outcome. The successful treatment experience of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in adult peritoneal carcinoma has been applied to pediatric peritoneal malignancy in recent years. However, patients with desmoplastic small round cell tumor (DSRCT) accounted for the majority of patients treated with CRS and HIPEC in previous studies. The role of CRS and HIPEC remains controversial due to the rarity of the disease and the limited sample size of studies. Additionally, the cases using CRS and HIPEC except DSRCT were mainly small case reports with unclear outcomes. We present our experience in the treatment of pediatric peritoneal malignancies using CRS and HIPEC, with more emphasis on the safety, feasibility, and short-term outcome.MethodsA retrospective query from December 2019 to February 2022 identified 19 children with peritoneal malignancies who underwent CRS and HIPEC in our institution. Clinical characteristics, therapies, and outcomes were summarized and analyzed.ResultsThe median age of the patients was 6.4 years (range, 0.7–13.9 years). The histologic types included rhabdomyosarcoma (7), Wilms tumor (2), clear cell sarcoma of the kidney (2), undifferentiated sarcoma (2), immature teratoma (1), peritoneal serous carcinoma (1), malignant rhabdoid of the kidney (1), malignant germ cell tumor (1), neuroblastoma (1), and epithelioid inflammatory myofibroblast sarcoma (1). Seven patients underwent initial operation, and 12 patients received reoperation for tumor recurrence. The median peritoneal carcinomatosis index was 5 (range, 2–21). There were no perioperative deaths or life-threatening complications of CRS and HIPEC. Two patients had grade 3 complications of wound infection and wound dehiscence. With a median follow-up time of 14 months (range, 1.5–31 months), 14 patients were alive, and 5 died of tumor recurrence. Of the 14 patients who were alive, 2 relapsed after CRS and HIPEC and then received radiotherapy and molecular-targeted therapy or chemotherapy.ConclusionsCRS and HIPEC are safe and feasible in children, without increasing serious complications in the peri- and postoperative periods. The complication is acceptable. The short-term outcome shows possible effectiveness in pediatric peritoneal malignant tumors. The long-term effectiveness needs to be verified by additional cases and long-term follow-ups.
Reseña Geografía y educación sexual integral
Authors: Ensabella Beatriz 
Published: January 2023

La preocupación central del libro es, la vinculación entre Geografía y ESI en la enseñanza secundaria. Al respecto, cabe recordar que la Ley N° 26.150 del 2006, establece que todxs lxs educandos tienen derecho a recibir ESI en todos los establecimientos educativos públicos de gestión estatal y privada, entendiéndose como ESI la que articula aspectos biológicos, psicológicos, sociales, afectivos y éticos. La ESI forma parte de la identidad de lxs jóvenes y apunta fundamentalmente a revisar la forma de relacionarse y promueve educar desde el respeto y la inclusión.
El texto consta de una Introducción titulada “¿De qué se trata este libro?”, 4 capítulos que toman las dimensiones de los NAP (ambiental, política, socio-demográfica, económica), Bonus Track I, Taller sobre derecho a la ciudad (feminista) y Bonus track II, El caso de las maquiladoras en zonas fronterizas. Al final se anexan, glosario de conceptos, efemérides, glosario de leyes y materiales recomendados.
El texto logra traducir de forma didáctica, ese currículo de ESI en relación con la geografía para acercarlo a lxs profesores. Los nvita de manera explícita a que se animen a desarrollar estos temas, que encuentren conexiones entre los contenidos básicos de la disciplina y lo de la ESI y de este modo, romper la barrera de que la ESI se enseña en otras asignaturas.
Políticas, lugares y paisajes de la memoria sobre el terrorismo de Estado en la Argentina
Authors: Fabri Silvina 
Published: January 2023

Los escritos que convergen en este dossier constituyen una muestra del trabajo desplegado por el Equipo Lugares y Políticas de la memoria, con sede en el Instituto de Geografía Romualdo Ardissone de nuestra Facultad. Desde el año 1993, con la dirección de Cora Escolar, el equipo llevó adelante, gracias al apoyo continuo de subsidios UBACyT, investigaciones sobre las dimensiones espaciales e institucionales de distintas políticas públicas. A partir del año 2003, la relación entre las políticas y los lugares de la memoria como así también las nuevas territorialidades que en clave genealógica abrieron los procesos de memoria, verdad y justicia pasaron a ser el foco del interés y, desde entonces, la ampliación del equipo permitió entablar una larga conversación entre las formaciones disciplinares y las experiencias profesionales de quienes integramos este espacio de trabajo. Actualmente, el Proyecto UBACyT Políticas, territorios y escrituras de la memoria. Saberes expertos, prácticas militantes y dispositivos testimoniales en las configuraciones epistemológicas del pasado reciente (1955-2017), cuya labor culmina con la presentación de este dossier, es el que cobija nuestra lengua de cruce cocinada en el caldero de los estudios sobre memoria política y en los modos en que estos estudios activaron la traducción de lenguas, las preguntas por la multidisciplina, sobre qué hacer con lo intraducible entre las lenguas disciplinares y lo inclasificable de los objetos emergentes en los estudios sobre el pasado reciente, sobre la manera en que la geografía, para incorporar a su agenda la cuestión memorial, requiere acampar nuevamente en las tradiciones de la geografía cultural o política atentas, como señala Souto (2011) a los intensos diálogos con los estudios culturales o decoloniales. Nos atraviesan el cruce entre las disciplinas de las cuáles provenimos ya sean estas nativas o por naturalización (geografía, antropología, sociología, historia), los saberes que hemos explorado colectivamente, las áreas de estudio sobre memoria y política y las maneras en que el conocimiento producido ha nutrido el trabajo de las políticas de la memoria sobre el terrorismo de Estado y, más específicamente, las prácticas de gestión en los sitios y espacios de la memoria dedicados a la promoción de los derechos humanos (Besse y Escolar, 2019). Prácticas que en muchos casos han sido o son llevadas a cabo en el presente por algunxs de lxs integrantes del equipo que forman parte de la propuesta que ofrece el dossier.
Multiplication <em>in vitro</em> of strawberry plant under different types of LEDs
Authors: Da Rocha Paulo Sérgio Gomes , Ambros Gabriela Girelli , Canova Diogo Vitali 
Published: January 2023

Use of light-emitting diodes (LEDs) in strawberry in vitro multiplication The refinement of plant tissue culture techniques is of great importance for optimizing in vitro multiplication rates and improving the quality of micropropagated changes, either light-emitting diodes (LEDs) or the latest models of light-emitting light sources light..The objective of this work was to evaluate the effect of light type on in vitro multiplication of Tudla strawberry cultivar. Strawberry sprouts were grown for 30 days in MS culture medium plus 100 mg L-1 of myo-inositol, 7 g L-1 agar, 1.0 mg L-1 BAP and 30 g L-1 sucrose. The pH of the culture medium was adjusted to 5.8 prior to the addition of agar. The controls used were composed of three light types [(green LEDs - EDET 3LA1 530 nm, red LEDs - EDER 3LA3 630 nm and fluorescent lamps (control treatment)]. Note that the average number of sprouts formed by red LEDs (11 The buds /explant) was higher than ears under fluorescent lamps (7.8 buds /explant), the lowest average was observed under fluorescent lamps, but there was no difference between explants grown in green LEDs and red LEDs in vitro shoot of strawberry cultivar Tudla.
A nova regonalização do IBGE de 2017: Uma análise a partir do estado da Paraiba
Authors: Da Silva Elton Oliveira , Torres Ericson da Nóbrega 
Published: January 2023

Este trabalho é fruto de uma série de debates e reflexões surgidas durante a disciplina Regionalização e integração regional brasileira (a qual ministro), onde nos debruçamos sobre a atual regionalização do IBGE e seu impacto nas pesquisas, principalmente realizadas dentro do Estado da Paraíba. O principal objetivo analisar a nova regionalização do IBGE para o Brasil e em particular para o estado da Paraíba, visando demonstrar as mudanças e se de fato essa nova configuração possui bases concretas, ainda que isto se configure um debate inicial. Para realização deste trabalho, alguns procedimentos metodológicos foram realizados tais como, levantamento bibliográfico sobre o conceito de região, e regionalização, análise documental e de dados. A atual regionalização, apresentada em 2017, coloca como parâmetro basilar a identificação das cidades-polo e os municípios que possuem relação direta como cada uma delas, usando para isso dois conceitos: Território-rede e Território-zona. No Estado da Paraíba possuíamos quatro Mesorregiões e vinte e três Microrregiões, agora segundo a nova regionalização, temos quatro regiões Intermediárias e quinze regiões Imediatas, evidenciando que algumas das antigas microrregiões foram agrupadas para formarem as novas regiões Imediatas.
Evaluation of the groundwater quality index (GWQI) and the human health risk (HHR) on fluoride concentration in Namakkal district, South India
Authors: Karuppaiah Sankar , Duraisamy Shanthi , Kaliyan Kalaivanan 
Published: January 2023

This research aims to determine the health consequences of fluoride contamination of groundwater in the Namakkal region in south India using the groundwater quality index (GWQI). Study area latitude and longitude: 11° 00' and 11° 30' in the north, and 77° 45' and 78° 15' in the east. Statewide, it is among the largest districts in the state. The study region occupies an area of 3406.37 km2. The geology of the studied area is mainly based on the Archaean crystalline and metamorphic complex. The district's major aquifer systems are composed of crystalline rocks that are weathered and fractured and of colluvial deposits. Alluvium and colluvium are examples of porous formations in the cross-section. Only the main river channels have alluvial deposits. The phreatic properties of groundwater Depending on the topography, these aquifers may reach 5 m saturation thickness. Groundwater samples were obtained from 58 bore well sites across the study area during the North-East Monsoon (NEM) of 2015. pH concentrations in suitable drinking water regions during the seasons assist in limiting the availability of groundwater for drinking purposes. TDS are an important factor in determining water suitability for various purposes. The groundwater sample in the study area shows cation domination in ascending order of Na+ > Ca2+ > Mg2+ > K+ due to the dissolution of aquifer minerals in rainfall in the study area. In the NEM seasons, rock dominance and anthropogenic contributions to higher Na+ > Mg2+ > Ca2+ > K+ values. Fluoride concentration differentiates into three groups such as < 0.5 indicates low risk, 0.5 to 1.5 indicates moderate risk, and > 1.5 means high risk. More than 2 fluoride implies very high risk, whereas fluoride in the range of 1.5 to 2.24 suggests a very high risk. The appraisal of non-carcinogenic risk was done to stress the health issues that succeed due to the intake and dermal contact of drinking water in the Namakkal district. The percentage of risk HQ >1 shows that 48 men groundwater samples, followed by 46 groundwater samples women and 30 groundwater samples children, constitute possible health hazards. Overall, health risk estimation results showed that all the groundwater samples have surpassed the permissible limit of HQ <1 for children.