bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELAKSANAAN PEMUNGUTAN PAJAK SARANG BURUNG WALET DI KABUPATEN KAUR
Authors: Octavia Mayolla , Simamora Jonny , Wulandari Wulandari 
Published: August 2023

Salah satu sumber Pendapatan Asli Daerah (PAD) Kabupaten Kaur adalah pemungutan terhadap Pajak Sarang Burung Walet yang diatur berdasarkan Peraturan Daerah Kabupaten Kaur Nomor 03 Tahun 2014 Tentang Pajak Sarang Burung Walet sebagai pedoman dalam pelaksanaan pemungutan Pajak Sarang Burung Walet. Dalam pelaksanaannya, pemungutan Pajak Sarang Burung Walet belum berjalan dengan baik terlihat dari belum pernah terpenuhinya target pajak sarang burung walet setiap tahunnya. Penelitian ini bertujuan untuk mengetahui kondisi umum Pajak Daerah Kabupaten Kaur, pelaksanaan dan hambatan serta upaya yang dilakukan terhadap pelaksanaan Pemungutan Pajak Sarang Burung Walet di Kabupaten Kaur. Penelitian ini dilakukan dengan metode penelitian yuridis-empiris dan pendekatan non doktrinal. Yang mana hasil penelitian ini diperoleh dari observasi dan wawancara secara langsung kepada Kabid pendapatan BPKAD, Kepala KP2KP, dan 8 (delapan) orang Wajib Pajak. Dari hasil penelitian yang telah dilakukan dapat disimpulkan bahwa Pemungutan Pajak Sarang Burung Walet di Kabupaten Kaur belum terlaksana dengan baik yang disebabkan karena beberapa hambatan diantaranya belum maksimal dalam pengkajian dan pendataan oleh pemerintah daerah, kurangnya kesadaran Wajib Pajak, Kurangnya pengadaan pejabat fungsional tertentu, Kurangnya informasi dan sosialisasi terhadap kebijakan-kebijakan pajak daerah dan retribusi daerah, lemahnya pengawasan, dan tidak adanya sanksi yang tegas dan jelas bagi pelanggar.

Kata Kunci : Pajak Daerah, Sarang Burung Walet, Hambatan.
IMPLEMENTASI GERAKAN LITERASI MASYARAKAT (GELMAS) SESUAI PERATURAN BUPATI BIMA NOMOR 35 TAHUN 2019 DI KECAMATAN MONTA KABUPATEN BIMA NUSA TENGGARA BARAT
Authors: Suparjan Edy , Zulkifli Zulkifli , Irawan Roni 
Published: August 2023

Tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan implementasi Program Gerakan Literasi Masyarakat (GELMAS) di Kecamatan Monta Kabupaten Bima yang didasarkan pada Peraturan Bupati Bima Nomor 35 Tahun 2019 Tentang Gerakan Literasi di Kabupaten Bima Propinsi Nusa Tenggara Barat (NTB). Objek dalam penelitian ini adalah Desa Sakuru. Pemilihan objek tersebut disebabkan pada ketersediaan delapan indikator yang ada pada Peraturan Bupati Bima tersebut dibandingkan dengan 13 desa lain yang ada di kecamatan Monta. Manfaat penelitan ini diantaranya adalah untuk mengetahui pola implementasi gerakan literasi masyarakat di desa Sakuru. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif dengan pendekatan studi kasus. Sumber data dalam penelitian ini adalah Kepala Desa, Sekertaris Desa, Kepala Urusan Kesejahteraan, Karang Taruna, Pengurus Perpustakaan Desa dan Tokoh masyarakat. Instrumen penelitian berupa lembar wawancara, lembar observasi, dan alat dokumentasi. Analisis data menggunakan analisis data kualitatif berupa triangulasi versi Miles Huberman. Kesimpulan penelitian ini adalah bahwa model Implementasi Gerakan Literasi Masyarakat di Desa Sakuru diantaranya adalah; (1) Kegiatan Ceramah dan Kajian Islam oleh Majelis Ta’alim; (2) Kegiatan Marawis Oleh Majelis Ta’alim dan Remaja Masjid; (3) Lomba Bacaan Ayat pendek oleh Majelis Ta’alim dan Remaja Masjid; (4) Pengenalan huruf Hijaiyah; dan (5) Bimbingan Belajar. (6) Lomba Kaligrafi; (7) Lomba Master of Ceremony.
Kata Kunci: Implementasi, Literasi, Peraturan Bupati
Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits
Authors: Wells Alicia C. , Lotfipour Shahrdad 
Published: August 2023

Maternal tobacco use and nicotine exposure during pregnancy have been associated with adverse birth outcomes in infants and can lead to preventable pregnancy complications. Exposure to nicotine and other compounds in tobacco and electronic cigarettes (e-cigarettes) has been shown to increases the risk of miscarriage, prematurity, stillbirth, low birth weight, perinatal morbidity, and sudden infant death syndrome (SIDS). Additionally, recent data provided by clinical and pre-clinical research demonstrates that nicotine exposure during pregnancy may heighten the risk for adverse neurodevelopmental disorders such as Attention-Deficit Hyperactivity (ADHD), anxiety, and depression along with altering the infants underlying brain circuitry, response to neurotransmitters, and brain volume. In the United States, one in 14 women (7.2%) reported to have smoked cigarettes during their pregnancy with the global prevalence of smoking during pregnancy estimated to be 1.7%. Approximately 1.1% of women in the United States also reported to have used e-cigarettes during the last 3 months of pregnancy. Due to the large percentage of women utilizing nicotine products during pregnancy in the United States and globally, this review seeks to centralize pre-clinical and clinical studies focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (PNE) such as alterations to the hypothalamic-pituitary-adrenal (HPA) axis and brain regions such as the prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NA), hippocampus, and caudate as well as changes to nAChR and cholinergic receptor signaling, long-term drug seeking behavior following PNE, and other related developmental disorders. Current literature analyzing the association between PNE and the risk for offspring developing schizophrenia, attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), anxiety, and obesity will also be discussed.
Planktonic foraminifera fluxes and their response to the Asian Monsoon: insights from the Maldives, Indian Ocean
Authors: Cariño Maria Caezare Mae R. , Peleo-Alampay Alyssa M. , Wiesner Martin G. , de Silva Leopoldo P. , Lahajnar Niko , Betzler Christian , Fikree Ibrahim , Lüdmann Thomas 
Published: August 2023

This study describes seasonal changes in the fluxes of planktonic foraminifera in response to changes in environmental conditions during the Asian Monsoon. Sediment trap systems were deployed for a period of 1 year at two locations in the Maldives: Kardiva Channel and Inner Sea. Twenty-six (26) planktonic foraminifera were recognized, of which six species (Trilobatus sacculifer, Globorotalia menardii, Globigerinoides ruber, Globigerina siphonifera, Neogloboquadrina dutertrei, and G. bulloides) dominated the assemblage (82%–84%) in both sites. Planktonic foraminifera fluxes and chlorophyll-a concentrations are higher in the Inner Sea. Total planktonic foraminifera fluxes show preference to high nutrient conditions during monsoon periods. Planktonic foraminifera fluxes generally follow the trend of carbonate fluxes except during October-November 2014. Species flux generally reached maximum during the NE monsoon as a response to increase in nutrient concentration brought by the movement of the North Equatorial Current over the trap sites. The expansion of nutrient-rich surface waters, occurring eastward during the SW monsoon and westward during the NE monsoon, led to an increase in the population of species dwelling in both shallow (T. sacculifer and G. ruber) and deep waters (N. dutertrei and G. bulloides). Dominance of shallow-dwelling species T. sacculifer and G. ruber throughout the sampling period suggests stable stratification of the water column. This supports the idea of wind-mixing rather than local upwelling as the driving force for enrichment of nutrients and subsequent increase in planktonic foraminifera fluxes. Lateral advection and resuspension in settling of particles to the traps is evident based on the presence of benthic foraminifera in the Inner Sea samples. These processes, however, did not significantly mask climate and surface ocean signals since there remains a clear correlation between planktonic foraminifera fluxes and environmental conditions.
Impact of dipeptidyl peptidase-4 inhibitors on glucose-dependent insulinotropic polypeptide in type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Chai Shangyu , Zhang Ruya , Carr Richard David , Deacon Carolyn F. , Zheng Yiman , Rajpathak Swapnil , Chen Jingya , Yu Miao 
Published: August 2023

AimsGlucose-dependent insulinotropic polypeptide (GIP) confers a variety of metabolic benefits in type 2 diabetes mellitus (T2DM). This meta-analysis was conducted to investigate the impact of dipeptidyl peptidase 4 (DPP4) inhibitors on GIP levels in T2DM patients.MethodsMedline (PubMed), CENTER (Cochrane Library), and Embase (Ovid) were searched and randomized controlled trials (RCTs) evaluating the impact of DPP4 inhibitors on fasting and postprandial GIP levels were obtained. For postprandial GIP, only studies with the data of GIP changes reported as the total area under the curve (AUCGIP) using a meal or oral glucose tolerance test were included. A random-effects model was used for data pooling after incorporating heterogeneity.ResultsOverall, 14 RCTs with 541 T2DM patients were included. Compared to placebo/no treatment, the use of DPP4 inhibitors significantly increased the fasting GIP level (standard mean difference [SMD]: 0.77, 95% confidence interval [CI]: 0.48–1.05, P&lt;0.001; I2 = 52%) and postprandial AUCGIP (SMD: 1.33, 95% CI: 1.02–1.64, P&lt;0.001; I2 = 65%). Influence analysis by excluding one dataset at a time showed consistent results. Sensitivity analyses only including studies with radioimmunoassay showed also consistent results (fasting GIP: SMD: 0.75, 95% CI: 0.51–1.00, P&lt;0.001; I2 = 0%; and postprandial AUCGIP: SMD: 1.48, 95% CI: 1.18–1.78, P&lt;0.001; I2 = 54%). Further subgroup analyses demonstrated that the influence of DPP4 inhibitors on fasting and postprandial GIP levels in T2DM patients was not significantly changed by study characteristics such as study design, patient mean age, baseline glycated hemoglobin (HbA1c) concentration, body mass index (BMI), background treatment, treatment duration, or method for postprandial GIP measurement (all P for subgroup effects &lt;0.05).ConclusionThe use of DPP4 inhibitors effectively increases the fasting and postprandial GIP concentrations in T2DM patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022356716.
Predictors of successful outcome after adrenalectomy for unilateral primary aldosteronism
Authors: Saadi Ahmed , Bedoui Mohamed Ali , Zaghbib Selim , Boussaffa Hamza , Mokaddem Seif , Nacef Ibtissem Ben , Ayed Haroun , Derouiche Amine , Khiari Karima , Chakroun Marouene , Ben Slama Riadh 
Published: August 2023

IntroductionUnilateral primary aldosteronism (UPA) is the most frequent surgically curable form of endocrine hypertension. Adrenalectomy is the cornerstone of treatment for UPA, but outcomes after surgery are variable. The cause of resistant hypertension after surgery is still a matter of debate. Our aim was to investigate cure rates after surgery and to evaluate preoperative factors that might influence the surgical outcome.MethodsBetween 2000 and 2021, the charts of 71 Tunisian patients who underwent laparoscopic adrenalectomy for UPA were retrospectively reviewed. Preoperative medical records were collected and follow-up data (1-158 months) were registered. Antihypertensive medication doses were calculated using defined daily doses (DDD) and postoperative outcomes were assessed using the Primary Aldosteronism Surgical Outcome (PASO) criterion.ResultsOf 91 enrolled patients, 71 (59% women, mean age 46 years, median length of follow-up 21 months) were suitable for evaluation. Thirty-four patients (48%) had complete clinical success according to the PASO criteria. The most relevant factors associated with complete clinical success on univariate analysis were: absence of diabetes (p= 0.007), low body mass index (BMI) (p= 0.001), lower preoperative DDD (p= 0.01), preoperatively controlled blood pressure (p= 0.024), higher plasma aldosterone to renin ratio (ARR) (p= 0.001), adenoma subtyping (p &lt;0.001) and aldosteronoma resolution score (ARS) (p= 0.002). Multivariate regression analysis showed that the major predictors of complete clinical success were absence of diabetes (OR: 5.205), a BMI &lt; 30 (OR: 4.930), a plasma ARR &gt; 332 (OR: 4.554) and an ARS ≥ 3 (OR: 2.056).ConclusionComplete and partial clinical response rates were achieved in respectively 48 and 43% of cases. The main predictors of complete resolution of hypertension were absence of diabetes, low BMI, high plasma ARR and high ARS. Taking these factors into account may help identify patients at risk of persistent postoperative hypertension who may require long-term surveillance and medication.
Assessment of dyspneic sensation in patients with type 2 diabetes
Authors: Mizab Chadia , Sánchez Enric , Gutiérrez-Carrasquilla Liliana , Balsells Núria , Arqué Anaïs , Ruano Raquel , Mateu Magda , Zorzano-Martínez Marta , Pomés Anna , García-Aguilera Esther , Martí Raquel , Manzanares José María , Hernández Cristina , Simó Rafael , Lecube Albert 
Published: August 2023

IntroductionIndividuals with type 2 diabetes (T2D) should be considered a susceptible group for pulmonary dysfunction. So, we aimed to evaluate the sensation of breathlessness in this population by administering two well-validated questionnaires.MethodsThis is a crosssectional study with 592 people without known respiratory disease (353 with T2D) who answered the modified Medical Research Council (mMRC) questionnaire. In addition, 47% also responded to the St George Respiratory Questionnaire, a specific instrument designed to be applied to patients with obstructive airway disease.ResultsPatients with T2D showed a higher mMRC score in comparison to the control group [1.0 (0.0 – 4.0) vs. 0.0 (0.0 – 4.0), p&lt;0.001]. A higher prevalence of subjects with mMRC ≥2 was observed in T2D that in the control group (20.2% vs. 11.6%, p=0.004). Participants with T2D and mMRC ≥2 showed a higher HbA1c (8.2 ± 1.6% vs. 7.8 ± 1.6%, p=0.048), longer T2D evolution and higher prevalence of nephropathy. In the multivariate analysis, the presence of T2D [OR=1.95 (1.19 to 3.22), p=0.008] in all the population, and HbA1c [OR=1.19 (1.01 to 1.41), p=0.034] and the presence of diabetic nephropathy [OR=2.00 (1.14 to 3.52), p=0.015] in patients with T2D, predicted a mMRC ≥2. Finally, no differences were observed regarding the SGRQ score among groups.ConclusionsPatients with T2D showed a greater sensation of dyspnea than subjects with normal carbohydrate metabolism. Risk factors included poor metabolic control and the presence of renal disease.
Impact of inactivated COVID-19 vaccination on female ovarian reserve: a propensity score-matched retrospective cohort study
Authors: Huang Jialyu , Guan Tianshu , Tian Lifeng , Xia Leizhen , Xu Dingfei , Wu Xingwu , Huang Lingling , Chen Mengyi , Fang Zheng , Xiong Chaoyi , Nie Liju , Wang Shuang , Li Zengming , Zhao Yan , Wu Qiongfang 
Published: August 2023

PurposeTo explore the impact of inactivated COVID-19 vaccination on ovarian reserve as assessed by serum anti-Müllerian hormone (AMH) concentration.MethodsA total of 3160 women were included in this single-center retrospective cohort study between June 2021 and October 2022. Vaccination information were collected from official immunization records available in personal mobile apps. Serum AMH was qualified by electrochemiluminescence immunoassay and compared with previous measurement data within three years. Women were categorized to the vaccinated group if they received two doses of inactivated COVID-19 vaccines (Sinopharm or Sinovac) between AMH tests (n = 488), and to the control group if not vaccinated (n = 2672). Propensity score matching and multivariate linear regression were performed to control for potential confounders. The main outcome measures were the numeric AMH change and percentage AMH change between the two tests.ResultsThere were 474 women left in each group after matching all baseline characteristics. The mean interval from the first to second AMH measurement was 508.0 ± 250.2 and 507.5 ± 253.6 days for vaccinated and unvaccinated women, respectively (P = 0.680). Both groups had a significant AMH decrease in the second test compared with the first test (P = 0.001). However, the second AMH level remained comparable between groups (3.26 ± 2.80 vs. 3.24 ± 2.61 ng/mL, P = 0.757). Similarly, no significant differences were observed in numerical (-0.14 ± 1.32 vs. -0.20 ± 1.56 ng/mL, P = 0.945) and percentage (2.33 ± 58.65 vs. 0.35 ± 48.42%, P = 0.777) AMH changes. The results were consistent in sub-analyses for women aged &lt;35 and ≥35 years. There were also no significant differences when vaccinated women were divided according to the time interval after vaccination: ≤30, 31–60, 61–90, and ≥91 days.ConclusionOur study provides the first evidence that inactivated COVID-19 vaccination has no measurable detrimental effect on ovarian reserve, regardless of female age and vaccination interval. This reassuring finding adds to the safety evidence of COVID-19 vaccine in fertility, and should be useful to promote vaccine acceptance. Multicenter prospective cohort studies are needed to validate our conclusion.
Myeloid-associated differentiation marker is associated with type 2 asthma and is upregulated by human rhinovirus infection
Authors: Tanyaratsrisakul Sasipa , Dy Alane Blythe C. , Polverino Francesca , Numata Mari , Ledford Julie G. 
Published: August 2023

BackgroundHuman rhinoviruses are known to predispose infants to asthma development during childhood and are often associated with exacerbations in asthma patients. MYADM epithelial expression has been shown to associate with asthma severity. The goal of this study was to determine if MYADM expression patterns were altered in asthma and/or rhinovirus infection and if increased MYADM expression is associated with increased asthma-associated factors.MethodsUtilizing H1HeLa cells and differentiated primary human airway epithelial cells (AECs), we measured the expression of MYADM and inflammatory genes by qRT-PCR in the presence or absence of RV-1B infection or poly I:C treatment and with siRNA knockdown of MYADM. Expression of MYADM in the asthmatic lung was determined in the ovalbumin (ova)-challenged murine model.ResultsMYADM expression was upregulated in the lungs from ova-treated mice and in particular on the subsurface vesicle membrane in airway epithelial cells. Upon infection with RV-1B, human AECs grown at an air–liquid interface had increased the MYADM expression predominantly detected in ciliated cells. We found that the presence of MYADM was required for expression of several inflammatory genes both in a resting state and after RV-1B or poly I:C treatments.ConclusionsOur studies show that in a mouse model of asthma and during RV-1B infection of primary human AECs, increased MYADM expression is observed. In the mouse model of asthma, MYADM expression was predominantly on the luminal side of airway epithelial cells. Additionally, MYADM expression was strongly associated with increases in inflammatory genes, which may contribute to more severe asthma and RV-linked asthma exacerbations.
Jasmonates disrupt carrageenan synthesis during carposporogenesis in the red seaweed Grateloupia imbricata
Authors: Del Rosario-Santana Diana , Robaina Rafael , Garcia-Jimenez Pilar 
Published: August 2023

In this study, we monitored changes in cell wall sulfated galactans in the red seaweed Grateloupia imbricata after the rapid (48 h) induction of cystocarp maturation and carpospore development by the volatile hormone methyl jasmonate (MEJA). Synthesis of sulfated galactans, carrageenans, which requires sulfated UDP galactose, was followed by expression analysis of genes encoding phosphoglucomutase (PGM), galactose-1-phosphate uridyltransferase (GALT), and those responsible for sulfate assimilation (S-transporter and sulfate adenylyltransferase, SAT). In addition, the expression of carbohydrate sulfotransferase and galactose-6-sulfurylase responsible for the addition and removal of sulfate groups to the galactans backbone were evaluated. Structural changes, such as thallus softening, were analyzed using Fourier-transformed infrared spectroscopy (FTIR) spectra, and ploidy was assessed using flow cytometry. The results showed downregulation of most of the genes encoding precursors or those in charge of transformation into sulfated hexoses for cell wall synthesis. Furthermore, alterations in the FTIR spectrum of carrageenan from MEJA-induced fertile thalli, such as the disappearance and flattening of absorption bands, were observed. The promptness of these events and the ploidy of thalli and spores seem to confirm the induction of mitotic production of haploid spores by MEJA.
Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study
Authors: Molinari Paolo , Regalia Anna , Leoni Alessandro , Campise Mariarosaria , Cresseri Donata , Cicero Elisa , Vettoretti Simone , Nardelli Luca , Brigati Emilietta , Favi Evaldo , Messa Piergiorgio , Castellano Giuseppe , Alfieri Carlo M. 
Published: August 2023

PurposeWe studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).MethodsWe retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and mineral metabolism parameters at 1, 6, and 12 months after RTx. Graft loss and death with functioning graft during follow-up (FU, 8.3[5.4–11.4] years) were checked.ResultsAt month-1, 79% had HPT, of which 63% with secondary HPT (SHPT) and 16% tertiary HPT (THPT); at month-6, HPT prevalence was 80% of which SHPT 64% and THPT 16%; at month-12 HPT prevalence was 77% of which SHPT 62% and THPT 15%. A strong significant correlation was found between HPT type, PTH levels and graft loss at every time point. Mean PTH exposure remained strongly and independently associated to long term graft loss (OR 3.1 [1.4–7.1], p = 0.008). THPT was independently associated with graft loss at month-1 when compared to HPT absence and at every time point when compared to SHPT. No correlation was found with RTx-p death. Discriminatory analyses identified the best mean PTH cut-off to predict long-term graft loss to be between 88.6 and 89.9 pg/mL (AUC = 0.658). Cox regression analyses highlighted that THPT was strongly associated with shorter long-term graft survival at every time-point considered.ConclusionHigh PTH levels during 1st year of RTx seem to be associated with long term graft loss.