bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study
Authors: Quan Xiao-Qing , Ruan Lei , Zhou Hai-Rong , Gao Wei-Liang , Zhang Qing , Zhang Cun-Tai 
Published: February 2023

Abstract
The age-related decline in T-cell function among elderly individuals remains unclear. We thus investigated the interrelationship between T-cell subsets and age to identify the changes in T-cell phenotypes and develop an age prediction model for the elderly population. A total of 127 individuals aged >60 years were divided into three groups (youngest-old group, 61–70 years, n = 34; middle-old group, 71–80 years, n = 53; and oldest-old group, ≥ 81 years, n = 40). The percentage of CD8+CD28− cells (P = 0.001) was highest in the oldest-old group and then followed by the middle-old group, while the youngest-old group was the lowest. Both females and males demonstrated significant decreases in the absolute counts of CD4+CD45RA+ cells (P = 0.020; P = 0.002) and CD8+CD28+ cells (P = 0.015; P = 0.005) with age. Multivariate linear regression showed that the percentage of CD8+CD28− cells (P < 0.001) was an independent predictor of aging after adjusting for sex, body mass index, hospitalization duration, smoking, drinking, chronic medical illness, and medications at admission. In conclusion, our results suggest that aging in elderly individuals is accompanied by a decrease in the counts of T-cell subpopulations. CD8+CD28− cells may be potential targets for elderly individuals in antiaging-related immunosenescence.
Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua
Authors: Zareen Shehzad , Adnan Muhammad , Khan Shahid Niaz , Alotaibi Amal 
Published: February 2023

Abstract
The present research study was aimed to investigate the efficiency of selected medicinal plants against Plasmodium vivax. Crude methanolic extracts from the seeds of leaves of Datura stramonium, Parthenium hysterophorus, Calotropis procera, and Dodonaea viscosa were prepared. In addition, Atropine was also isolated from alkaloid components of Eucalyptus obliqua to evaluate their in vitro anti-plasmodial effects. It was observed that proguanil (positive control) and Atropine displayed strong anti-plasmodial activity (94.04 and 68.02%, respectively) against P. vivax at 0.1 mg/mL concentration while the leaf extracts of other medicinal plants did not exhibit any notable anti-plasmodial activity. It was concluded that alkaloids of E. obliqua plant’s extracts were rich in anti-plasmodial compound Atropine, which exhibit a remarkable anti-plasmodial activity against P. vivax. Anti-plasmodial action of medicinal plants are attributed to these phytochemicals. In vitro studies using medicinal plant’s extracts and standardized methods will help to make more powerful and cost-effective anti-plasmodial compounds.
Synthesis and characterization of silver nanoparticles usingOriganum onitesleaves: Cytotoxic, apoptotic, and necrotic effects on Capan-1, L929, and Caco-2 cell lines
Authors: Gecer Esma Nur 
Published: February 2023

AbstractIn this study,Origanum oniteswas used to synthesize the silver nanoparticles (AgNPs@Org). The structure of nanoparticles was identified by spectroscopic techniques. The maximum absorption was determined as 433 nm by UV-Vis spectroscopy. In Fourier-transform infrared spectroscopy spectrum, the characteristic signal was observed at 3,262 cm−1belonging to the OH group. The crystal structure of nanoparticles was revealed by X-ray diffraction analysis. The diffraction peaks (2θ) can be indexed to 111, 200, 220, 311, and 222 components representing the face-centered cubic unit structure. The spherical particle size was calculated as 18.1 nm by transmission electron microscopy. Cytotoxic effects of extract and AgNPs@Org were executed by MTT assay using Capan-1, L929, and Caco-2 cell lines. AgNPs@Org exhibited the excellent cytotoxic effect on Capan-1 cell lines with the viability of 37.6% (0.5 µg·mL−1). However, the effect ofO. onitesextract on the viability of Capan-1 cell lines was found to be 24.6% and 55.4% at 1.0 and 0.5 µg·mL−1, respectively. AgNPs@Org effect on Caco-2 cell lines was found as 31.7% (1.0 µg·mL−1). In the L929 cell lines, the noticeable lethal influence was not detected for extract and nanoparticles. In other words, the extract and AgNPs@Org did not act a cytotoxic effect on L929 cell lines.
A case of arboreal nest building in the small Japanese field mouse (Apodemus argenteus)
Authors: Kikuchi Hayato , Oshida Tatsuo 
Published: February 2023

Abstract
To better understand the arboreal activity of small mammals, we focused on the arboreal nest-building behaviour of Apodemus argenteus. Using a camera trap, we found that a mouse took 18 days to build a nest in a tree cavity. For a few days during the nest building period, the mouse intensively carried nesting materials (leaves) to the cavity, though not regularly. The mouse did not constantly carry nesting materials, but rather showed two peaks working activities at 02:00 and 22:00. Judging from the uneven working pattern, its nest-building behaviour may depend on environmental condition such as meteorological factors.
Perspectives on AI-driven systems for multiple sensor data fusion
Authors: Koch Wolfgang 
Published: February 2023

Abstract
Artificially intelligent automation has not only impact on sensor technologies, but also on comprehensive multiple sensor systems for assisting situational awareness and decision-making. This is particularly true for integrated Manned-unManned-Teaming (MuM-T), for example. From a systems engineering perspective which does not exclude applications in the defence domain, three tasks need to be fulfilled: (1) Design artificially intelligent automation in a way that human beings are mentally and emotionally able to master each situation. (2) Identify technical design principles to facilitate the responsible use of AI in ethically critical applications. (3) Guarantee that human decision makers always have full superiority of information, decision-making, and options of action. Our discussion of AI-driven systems for multiple sensor data fusion results in recommendations and key results. We are addressing the algorithms needed, the data to be processed, the programming skills required, the computing devices to be used, the inevitable anthropocentric design, the reviewing of R & D efforts necessary, and the integration of different dimensions in a systems-of-systems point of view.
HIF-1α participates in secondary brain injury through regulating neuroinflammation
Authors: Xu Xiaojian , Yang Mengshi , Zhang Bin , Dong Jinqian , Zhuang Yuan , Ge Qianqian , Niu Fei , Liu Baiyun 
Published: February 2023

Abstract
A deeper understanding of the underlying biological mechanisms of secondary brain injury induced by traumatic brain injury (TBI) will greatly advance the development of effective treatments for patients with TBI. Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator of cellular response to hypoxia. In addition, growing evidence shows that HIF-1α plays the important role in TBI-induced changes in biological processes; however, detailed functional mechanisms are not completely known. The aim of the present work was to further explore HIF-1α-mediated events after TBI. To this end, next-generation sequencing, coupled with cellular and molecular analysis, was adopted to interrogate vulnerable events in a rat controlled cortical impact model of TBI. The results demonstrated that TBI induced accumulation of HIF-1α at the peri-injury site at 24 h post-injury, which was associated with neuronal loss. Moreover, gene set enrichment analysis unveiled that neuroinflammation, especially an innate inflammatory response, was significantly evoked by TBI, which could be attenuated by the inhibition of HIF-1α. Furthermore, the inhibition of HIF-1α could mitigate the activation of microglia and astrocytes. Taken together, all these data implied that HIF-1α might contribute to secondary brain injury through regulating neuroinflammation.
Cocrystals; basic concepts, properties and formation strategies
Authors: Khan Shahab , Zahoor Muhammad , Rahman Mudassir Ur , Gul Zarif 
Published: February 2023

Abstract
Cocrystallization is an old technique and remains the focus of several research groups working in the field of Chemistry and Pharmacy. This technique is basically in field for improving physicochemical properties of material which can be active pharmaceutical ingredients (APIs) or other chemicals with poor profile. So this review article has been presented in order to combine various concepts for scientists working in the field of chemistry, pharmacy or crystal engineering, also it was attempt to elaborate concepts belonging to crystal designing, their structures and applications. A handsome efforts have been made to bring scientists together working in different fields and to make chemistry easier for a pharmacist and pharmacy for chemists pertaining to cocrystals. Various aspects of chemicals being used as co-formers have been explored which predict the formation of co-crystals or molecular salts and even inorganic cocrystals.
Sensation Seeking dan Problematic Mobile Phone Use pada Mahasiswa
Authors: Ayuningtyas Alfina Diani , Amawidyati Sukma Galuh 
Published: February 2023

Perkembangan teknologi komunikasi yang pesat semakin mempermudah proses interaksi sosial antar manusia. Namun, disisi lain juga menimbulkan pemasalahan psikologis baru seperti problematic mobile phone used. Penelitian ini bertujuan untuk mengetahui hubungan antara sensation seeking dengan empat dimensi dari problematic mobile phone use yaitu dangerous use, dependence, financial problem, dan prohibity use pada mahasiswa. Desain penelitian merupakan penelitian kroseksional. Teknik pengambilan sampel adalah cluster random sampling yang mana subjek penelitian berjumlah 370 orang mahasiswa. Analisis korelasi pada penelitian ini menggunakan range spearman. Hasil penelitian menunjukkan bahwa terdapat korelasi positif antara sensation seeking dengan dimensi dangerous use dan prohibity use dengan uji hipotesis didapatkan koefisien korelasi 0,272 dan 0,132. Tidak terdapat korelasi antara sensation seeking dengan dimensi financial problem dan dependence dengan uji hipotesis didapatkan koefisien korelasi 0,049 dan 0,026. Kesimpulannya adalah sensation seeking, financial problem dan dependence pada mahasiswa berada pada kategori sedang sedangkan dimensi dangerous use dan prohibity use berada pada kategori rendah. The rapid development of communication technology has made the process of social interaction between humans easier. However, on the other hand, it also raises new psychological problems such as problematic mobile phone use. This study aims to determine the relationship between sensation seeking and the four dimensions of problematic mobile phone use, namely dangerous use, dependence, financial problem, and prohibited use in students. The research design is crossectional research. The sampling technique was random cluster sampling in which the research subjects were 370 students. Correlation analysis in this study used the spearman range. The results showed a positive correlation between sensation seeking and the dimensions of dangerous use and prohibited use. With hypothesis testing, the correlation coefficients were 0.272 and 0.132. There is no correlation between sensation seeking and the dimensions of financial problems and dependence. With hypothesis testing, the correlation coefficients are 0.049 and 0.026. The conclusion is that sensation seeking, financial problems, and dependence on students are moderate. The dimensions of dangerous use and prohibited use are in the low category.
Reading Books While Listening Music: Case Study To Students Of Universitas Negeri Semarang
Authors: Alfaridzi Fahri , Utomo Udi 
Published: February 2023

Researchers conducted a case study on reading while listening music in Universitas Negeri Semarang students. The purpose of this study is to find out and explain what types of music students listen to while reading and to find out and explain how the functions of music that students listen to while reading. This study used Mix Method Research (MMR), which is a research method that combines qualitative and quantitative methods with a phenomenological approach. Data collection techniques used in this study were questionnaires and interviews. Data validity uses source triangulation. The results of this study indicate that the types of music that can be used as a medium to increase students' reading concentration are popular types of music, and also types of music with the same theme as the reading books they are reading.
From the percentage, it can be concluded that music has an influence when it is listened to along with reading activities. The influence felt by respondents when listening to music together with reading activities is that it can make them comfortable, focus, and support the story or book they are reading.
III powstanie śląskie we wspomnieniach porucznik Leopoldyny Staweckiej
Authors: Trąba Mariusz 
Published: February 2023

Leopoldyna Stawecka (1896–1933) was one of many volunteers, who went to Upper Silesia immediately after hearing about the beginning of the Third Silesian Uprising, to take part in the fight. In the time of fights for the borders of the Second Polish Republic Leopoldyna Stawecka, who belonged to the Voluntary Legion of Women, took part in the defence of Lvov (1918/1919) and she also fought in the Polish-Soviet War at Vilnius and Warsaw. Year 1921 was for Leopoldyna Stawecka time of deep internal crisis; the crisis was caused by various reasons such as: the end of the fights and withdrawing of feminine divisions from the direct fight, loss of trust to many close people and family problems connected with her husband captain A. Popkowski.Leopoldyna Stawecka took part in the Third Silesian Uprising where she was a manager of so called a sanitary provision unit. Emotions and feelings coming from that period are described in her diary which one piece is printed below. She was offended by lack of discipline in fighting units, dishonesty and waste of gifts sent from the whole Poland, as well as getting a soldier’s pay for a lofty idea of fight for the country. She refused to accept the soldier’s pay for the time when she fought in Upper Silesia. In the time of the Third Silesian Uprising in Upper Silesia Capt. Józef Popkowski came; he wanted to force his wife to come back home. He did not succeed and the Silesian Uprising became the background of their final break. Leopoldyna Stawecka’s memoirs are one of few documents which describe uprisings from a very personal, feminine perspective.
Expression of Class II Human Leukocyte Antigens on Human Endothelial Cells Shows High Interindividual and Intersubclass Heterogeneity
Authors: Béland Stéphanie , Désy Olivier , El Fekih Rania , Marcoux Meagan , Thivierge Marie-Pier , Desgagné Jean-Simon , Latulippe Eva , Riopel Julie , Wagner Eric , Rennke Helmut G. , Weins Astrid , Yeung Melissa , Lapointe Isabelle , Azzi Jamil , De Serres Sacha A. 
Published: February 2023

Significance Statement
Donor-specific antibodies against class II HLA are a major cause of chronic kidney graft rejection. Nonetheless, some patients presenting with these antibodies remain in stable histological and clinical condition. This study describes the use of endothelial colony-forming cell lines to test the hypothesis of the heterogeneous expression of HLA molecules on endothelial cells in humans. Flow cytometry and immunofluorescence staining revealed substantial interindividual and interlocus variability, with HLA-DQ the most variable. Our data suggest that the expression of HLA class II is predicted by locus. The measurement of endothelial expression of HLA class II in the graft could present a novel paradigm in the evaluation of the alloimmune risk in transplantation and certain diseases.

Background
HLA antigens are important targets of alloantibodies and allospecific T cells involved in graft rejection. Compared with research into understanding alloantibody development, little is known about the variability in expression of their ligands on endothelial cells. We hypothesized individual variability in the expression of HLA molecules.

Methods
We generated endothelial colony forming cell lines from human peripheral blood mononuclear cells (n=39). Flow cytometry and immunofluorescence staining were used to analyze the cells, and we assessed the relationship between HLA-DQ expression and genotype. Two cohorts of kidney transplant recipients were analyzed to correlate HLA-DQ mismatches with the extent of intragraft microvascular injury.

Results
Large variability was observed in the expression of HLA class II antigens, not only between individuals but also between subclasses. In particular, HLA-DQ antigens had a low and heterogeneous expression, ranging from 0% to 85% positive cells. On a within-patient basis, this expression was consistent between endothelial cell colonies and antigen-presenting cells. HLA-DQ5 and -DQ6 were associated with higher levels of expression, whereas HLA-DQ7, -DQ8, and -DQ9 with lower. HLA-DQ5 mismatches among kidney transplant recipients were associated with significant increase in graft microvascular.

Conclusion
These data challenge the current paradigm that HLA antigens, in particular HLA class II, are a single genetic and post-translational entity. Understanding and assessing the variability in the expression of HLA antigens could have clinical monitoring and treatment applications in transplantation, autoimmune diseases, and oncology.
Domesticidades interpeladas en la Ciudad de Buenos Aires desde comienzos de siglo XX. Cultura material, modos y formas de habitar el espacio doméstico.
Authors: Sánchez Sandra Inés 
Published: February 2023

Según el diccionario, la domesticidad, calidad o condición de lo doméstico relativa a la vivienda o el hogar, implica un acto de domesticación, de reducción y acostumbramiento a la vista y compañía de aquello foráneo o salvaje. Implica una interioridad y lleva implícita un concepto de naturaleza, de otredad y un proceso de naturalización de aquello que se vislumbra como ajeno. Tratar sobre la domesticidad es tratar sobre las formas y modos de habitar que evidencian las relaciones entre personas y entre las personas y los objetos, y sobre las significaciones, simbolizaciones y sentidos que dan consistencia al espacio doméstico en la cultura urbana.
Se analizarán las concepciones sobre la domesticidad desde comienzos de siglo XX, con la finalidad de dar cuenta sobre los procesos de persistencia o transformación de sus modelos e imaginarios de referencia (disciplinares, académicos, profesionales, populares y comerciales).
Pengembangan Antologi Cerpen Suara Batin Berbasis Nilai-Nilai Pancasila bagi Remaja
Authors: Arini Nurvita , Jayanti Cicik Tri 
Published: February 2023

Abstract: The case of a brawl between two teenager groups in Central Jakarta because they offended each other on social media shows a lack of understanding of the sense of unity. An anthology of Suara Batin short stories acts as a solution in introducing the values of Pancasila to teenagers. The purpose of this research are: 1) to describe the needs analysis on the development of the Suara Batin short story anthology; 2) to describe the process of developing the short story anthology; and 3) to describe the results of validation on the short story anthology. This research method is research and development with a 4D model. The results of this research are: 1) a definition of the need for the development of an anthology of Suara Batin short stories which is sourced from ten online news articles and interviews with a member of the Pemuda Pancasila organization; 2) producing the anthology of Suara Batin short stories; and 3) a short story anthology got percentage scores of 74.98, and 89 based on validation by Indonesian language and literature experts, Pancasila education experts, and design experts. The average validity of the three validations got very decent criteria with a percentage score of 88.
Keywords: Pancasila values; short story anthology; 4D
Abstrak: Kasus tawuran antara dua kelompok remaja di Jakarta Pusat karena saling tersinggung di media sosial menunjukkan kurangnya pemahaman terhadap rasa persatuan. Antologi cerpen berjudul Suara Batin bisa berperan sebagai salah satu solusi dalam mengenalkan nilai-nilai Pancasila kepada remaja. Adapun tujuan dari penelitian ini adalah: 1) mendeskripsikan hasil analisis kebutuhan terhadap pengembangan antologi cerpen Suara Batin; 2) mendeskripsikan proses pengembangan antologi cerpen Suara Batin; dan 3) mendeskripsikan hasil validasi oleh ahli terhadap karya antologi cerpen Suara Batin. Metode penelitian ini menggunakan jenis penelitian dan pengembangan dengan model 4D. Hasil penelitian ini adalah: 1) definisi kebutuhan terhadap pengembangan antologi cerpen berjudul Suara Batin yang bersumber dari sepuluh artikel berita online dan wawancara kepada salah satu anggota organisasi Pemuda Pancasila; 2) menghasilkan produk antologi cerpen berjudul Suara Batin; dan 3) buku antologi cerpen Suara Batin mendapatkan skor persentase sebesar 74,98, dan 89 berdasarkan validasi oleh ahli di bidang bahasa dan sastra Indonesia, ahli di bidang pendidikan Pancasila, dan ahli di bidang desain. Rata-rata kevalidan dari ketiga validasi tersebut mendapatkan kriteria sangat layak dengan skor persentase sebesar 88.
Kata kunci: nilai-nilai Pancasila; antologi cerpen; 4D