bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perturbing the symmetric orbifold from the worldsheet
Authors: Fiset Marc-Antoine , Gaberdiel Matthias R. , Naderi Kiarash , Sriprachyakul Vit 
Published: July 2023

Abstract
The symmetric orbifold of 𝕋4 is the analogue of free SYM in four dimensions, and its dual is described by a tensionless string propagating in AdS3 × S3 × 𝕋4. In this paper we study the deformation of this exact AdS/CFT duality away from the free point. On the symmetric orbifold side this amounts to perturbing the theory by the exactly marginal operator from the 2-cycle twisted sector. We identify the corresponding perturbation in the dual worldsheet description, and show that the anomalous conformal dimensions of a number of symmetric orbifold currents are correctly reproduced from this worldsheet perspective.
Effective approach to the Antoniadis-Mottola model: quantum decoupling of the higher derivative terms
Authors: Silva Wagno Cesar e , Shapiro Ilya L. 
Published: July 2023

Abstract
We explore the decoupling of massive ghost mode in the 4D (four-dimensional) theory of the conformal factor of the metric. The model was introduced by Antoniadis and Mottola in [1] and can be regarded as a close analog of the fourth-derivative quantum gravity. The analysis of the derived one-loop nonlocal form factors includes their asymptotic behavior in the UV and IR limits. In the UV (high energy) domain, our results reproduce the Minimal Subtraction scheme-based beta functions of [1]. In the IR (i.e., at low energies), the diagrams with massive ghost internal lines collapse into tadpole-type graphs without nonlocal contributions and become irrelevant. On the other hand, those structures that contribute to the running of parameters of the action and survive in the IR, are well-correlated with the divergent part (or the leading in UV contributions to the form factors), coming from the effective low-energy theory of the conformal factor. This effective theory describes only the light propagating mode. Finally, we discuss whether these results may shed light on the possible running of the cosmological constant at low energies.
The planar limit of integrated 4-point functions
Authors: Fiol Bartomeu , Kong Ziwen 
Published: July 2023

Abstract
We study the planar limit of integrated 4-point functions of moment map operators of 𝒩 = 2 SU(N) SQCD. We do so by considering the planar free energy on S4 of the massive deformation of this theory, and taking advantage of the exact relation between this free energy and the integrated 4-point function. For this planar free energy we derive all the terms with maximal and next-to-maximal transcendentality, and present a procedure to compute terms of lower transcendentality. We also derive the first non-planar corrections, as all order series in the ’t Hooft coupling, and to all orders in transcendentality. Finally, we also apply our approach to the better studied example of 𝒩 = 4 SU(N) SYM integrated 4-point functions, and reproduce their known planar limit.
Couplings and primitives on topological spaces
Authors: Voigt Jürgen 
Published: July 2023

AbstractFor an open covering $$\hspace{0.55542pt}\mathcal {U}$$

U

of a topological space and a mapping "Equation missing", where $$\mathcal {I}:=\bigl \{(U,V)\in \hspace{0.55542pt}\mathcal {U}\times \hspace{0.55542pt}\mathcal {U}{;}\;U\cap V\ne \varnothing \bigr \}$$

I
:
=

{

(
U
,
V
)
∈

U
×

U
;

U
∩
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≠
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, we present conditions for the existence of a mapping "Equation missing" satisfying $$C_V-C_U=d_{UV}$$

C
V

-

C
U

=

d

UV

for all $$(U,V)\in \mathcal {I}$$

(
U
,
V
)
∈
I

. The result is applied to a Poincaré type theorem concerning distributional potentials. We also put the result into the context of algebraic topology.
Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways
Authors: Tito Claudia , Genovese Ilaria , Giamogante Flavia , Benedetti Anna , Miglietta Selenia , Barazzuol Lucia , Cristiano Loredana , Iaiza Alessia , Carolini Sabatino , De Angelis Luciana , Masciarelli Silvia , Nottola Stefania Annarita , Familiari Giuseppe , Petrozza Vincenzo , Lauriola Mattia , Tamagnone Luca , Ilari Andrea , Calì Tito , Valdivia Hector H. , Valdivia Carmen R. , Colotti Gianni , Fazi Francesco 
Published: July 2023

AbstractThe epidermal growth factor receptor (EGFR) is one of the main tumor drivers and is an important therapeutic target for many cancers. Calcium is important in EGFR signaling pathways. Sorcin is one of the most important calcium sensor proteins, overexpressed in many tumors, that promotes cell proliferation, migration, invasion, epithelial-to-mesenchymal transition, malignant progression and resistance to chemotherapeutic drugs. The present work elucidates a functional mechanism that links calcium homeostasis to EGFR signaling in cancer. Sorcin and EGFR expression are significantly correlated and associated with reduced overall survival in cancer patients. Mechanistically, Sorcin directly binds EGFR protein in a calcium-dependent fashion and regulates calcium (dys)homeostasis linked to EGF-dependent EGFR signaling. Moreover, Sorcin controls EGFR proteostasis and signaling and increases its phosphorylation, leading to increased EGF-dependent migration and invasion. Of note, silencing of Sorcin cooperates with EGFR inhibitors in the regulation of migration, highlighting calcium signaling pathway as an exploitable target to enhance the effectiveness of EGFR-targeting therapies.
Unified Filter Order Estimate for Minimax-Designed Linear-Phase FIR Wideband and Lowpass Digital Differentiators
Authors: Wang Yinan , Deng Mingxin , Johansson Håkan , Li Zhiwei , Li Qingjiang 
Published: July 2023

AbstractDigital differentiators enable the computation of the derivative of a continuous-time signal at discrete time instances, and they are used in many signal processing applications. This paper derives a unified filter order estimate for digital differentiators that are realized with linear-phase finite-length impulse response filters and designed in the minimax sense. The estimate is useful at the high-level system design when assessing the implementation complexity and it enables fewer designs when finding the minimal filter order required to satisfy a prescribed tolerable approximation error. The proposed unified estimate covers both wideband and lowpass differentiators of integer degrees up to ten. Furthermore, degree-individual filter order estimates are derived which improve and extend previous results. The performance of both the unified and degree-individual order estimates is evaluated through simulation examples and compared with previous estimates.
Accuracy of VO2 estimation according to the widely used Krakau formula for the prediction of cardiac output
Authors: Reiter Theresa , Kerzner Julia , Fette Georg , Frantz Stefan , Voelker Wolfram , Ertl Georg , Bauer Wolfgang , Morbach Caroline , Störk Stefan , Güder Gülmisal 
Published: July 2023

AbstractBackgroundInvasive cardiac output (CO) is measured with the thermodilution (TD) or the indirect Fick method (iFM) in right heart catheterization (RHC). The iFM estimates CO using approximation formulas for oxygen consumption ($$\dot {\mathrm{V}}$$V̇O2), but there are significant discrepancies (> 20%) between both methods. Although regularly applied, the formula proposed by Krakau has not been validated. We compared the CO discrepancies between the Krakau formula with the reference (TD) and three established formulas and investigated whether alterations assessed in cardiac magnetic resonance imaging (CMR) determined the extent of the deviations.MethodsThis retrospective study included 188 patients aged 63 ± 14 years (30% women) receiving both CMR and RHC. The CO was measured with TD or with the iFM using the formulas by Krakau, LaFarge, Dehmer, and Bergstra for$$\dot {\mathrm{V}}$$V̇O2 estimation (iFM-K/-L/-D/-B). Percentage errors were calculated as twice the standard deviation of the difference between two CO methods divided by their means; a cut-off of < 30% was regarded as acceptable.The iFM and TD-derived CO ratio was built, and deviations > 20% were counted. Logistic regression analyses were performed to identify determinants of a deviation of > 20%.ResultsThe TD-derived CO (5.5 ± 1.7 L/min) was significantly different from all iFM (K: 4.8 ± 1.6, L: 4.3 ± 1.6; D: 4.8 ± 1.5 L/min; B: 5.4 ± 1.8 L/min allp < 0.05). The iFM-K-CO differed from all methods (p < 0.001) except iFM‑D (p = 0.19). Percentage errors between TD-CO and iFM-K/-L/-D/-B were all beyond the acceptance limit (44/45/44/43%), while percentage errors between iFM‑K and other iFM were all < 16%. None of the parameters measured in CMR was predictive of a discrepancy of > 20% between both methods.ConclusionThe Krakau formula was comparable to other iFM in estimating CO levels, but none showed satisfactory agreement with the TD method. Improved derivation cohorts for$$\dot {\mathrm{V}}$$V̇O2estimation are needed that better reflect today’s patients undergoing RHC.
Evaluation der Einführung der HIV-Präexpositionsprophylaxe als Leistung der gesetzlichen Krankenversicherung (EvE‑PrEP)
Authors: Schmidt Daniel , Kollan Christian , Schewe Knud , Hanhoff Nikola , Rüsenberg Robin , Friebe Martin , Schikowski Tim , Schink Susanne Barbara , Marcus Ulrich , Koppe Uwe , Jansen Klaus , Streeck Hendrik , Ottensmeyer Patrick , an der Heiden Matthias , Bannert Norbert , M’Bayo Rosaline , Ceres Maia , Weber Lukas , Sweers Holger , Schmidt Axel Jeremias , Tietz Helge , Danan Emmanuel , Bendig Jörg , Kloep Stephan , Neumann Anja , Valbert Frederik , Wasem Jürgen , Bartmeyer Barbara , Bremer Viviane ,   NEPOS Studiengruppe
Published: July 2023

Zusammenfassung
Hintergrund
Untersucht wurden die Auswirkungen der HIV-Präexpositionsprophylaxe (PrEP) als neue Leistung der gesetzlichen Krankenversicherung (GKV) auf das Infektionsgeschehen von HIV und anderen sexuell übertragbaren Infektionen (STI) in Deutschland. Zusätzlich wurden PrEP-Bedarfe sowie Zugangsbarrieren analysiert.

Methoden
Im Rahmen des Evaluationsprojektes wurden folgende Daten ausgewertet: HIV- und Syphilis-Meldedaten und erweiterte Surveillance des Robert Koch-Instituts (RKI), Apothekenabrechnungsdaten, GKV-Daten, PrEP-Gebrauch in HIV-Schwerpunktzentren, Checkpoint‑, BRAHMS- und PrApp-Studie sowie ein Community-Beirat.

Ergebnisse
Die PrEP-Nutzenden waren zum größten Teil männlich (98–99 %), zum Großteil im Alter zwischen 25–45 Jahren und überwiegend deutscher Staatsangehörigkeit oder Herkunft (67–82 %). Der Großteil zählte zur Gruppe der Männer, die Sex mit Männern haben (99 %). In Bezug auf HIV-Infektionen zeigte sich die PrEP als hocheffektiv. Es fanden nur vereinzelt HIV-Infektionen statt (HIV-Inzidenzrate 0,08/100 Personenjahre), in den meisten Fällen war der vermutete Grund eine geringe Adhärenz. Die Inzidenzen von Chlamydien, Gonorrhö und Syphilis nahmen nicht zu, sondern blieben nahezu gleich oder gingen sogar zurück. Es zeigte sich Informationsbedarf zur PrEP für Personen in trans*/nichtbinären Communitys, Sexarbeitende, Migrant*innen und Drogengebrauchende. Notwendig wären bedarfsgerechte Angebote für Zielgruppen mit erhöhtem HIV-Risiko.

Diskussion
Die PrEP erwies sich als eine sehr wirkungsvolle HIV-Präventionsmethode. Die teils befürchteten indirekten negativen Einflüsse auf STI-Raten wurden in dieser Untersuchung nicht bestätigt. Aufgrund der zeitlichen Überschneidung mit den Eindämmungsmaßnahmen während der COVID-19-Pandemie wäre für eine abschließende Beurteilung ein längerer Beobachtungszeitraum wünschenswert.
Ultrasound-assisted extraction of cranberry seed oil: food waste valorization approach
Authors: Piasecka Iga , Brzezińska Rita , Ostrowska-Ligęza Ewa , Wiktor Artur , Górska Agata 
Published: July 2023

AbstractCranberry pomace considered as a by-product of fruit industry contains seeds which may be processed to highly nutritive oil. Conventional extraction methods may be, however, harmful to natural environment, thus alternative, ultrasound-assisted extraction method may be useful tool to reduce environmental impact. In the following study, sonication was applied to extract oil from cranberry seeds. The aim of the study was to determine the most efficient conditions of ultrasound-assisted extraction of oil and to investigate sonication influence on the properties of final product. Ultrasound amplitude and extraction time were independent variables; yield and maximum induction time of oils were responses. The most efficient conditions were amplitude of 95% and extraction time of 11.38 min. Model predicted extraction yield of 22.55 ± 0.36% (vs. actual 21.98 ± 0.08%) and induction time of 52.60 ± 0.95 min (vs. actual 61.95 ± 3.06 min). Detailed analyses of oil extracted in the most efficient conditions and the control sample were performed. Kinetic parameters of oil oxidation, fatty acid profile and distribution, melting characteristics studies were carried out. Sonication influenced activation energy of oxidation reaction, contribution of chosen fatty acids (oleic, α-linolenic and eicosenoic fatty acids) and distribution of oleic and α-linolenic fatty acids in sn-2 position of triacylglycerols. Slight changes in melting profile of oils were also recorded. Scanning electron microscopy of cranberry seeds revealed that ultrasound treatment resulted in pore enlargement and fat agglomeration damage. Additional studies of thermal properties of cranberry seeds: differential scanning calorimetry and modulated differential scanning calorimetry were performed, which confirmed that cranberry seeds may be a new source of oil with unique properties.
A phase 1 study in healthy participants to characterize the safety and pharmacology of inclacumab, a fully human anti-P-selectin antibody, in development for treatment of sickle cell disease
Authors: Mayer Christina Lourdes , Koeck Kathleen , Hottmann Margot , Redfern Andrew , Davis Mark , Barth Aline , Geng Xin , Hoppe Carolyn , Yue Patrick 
Published: July 2023

Abstract
Purpose
We evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) inclacumab, a fully human IgG4 anti–P-selectin monoclonal antibody in development for the treatment of sickle cell disease, at doses up to and exceeding those previously tested in healthy individuals.

Methods
In this phase 1, open-label, single-ascending-dose study, 15 healthy participants were enrolled into cohorts receiving 20 mg/kg (n = 6) or 40 mg/kg (n = 9) IV inclacumab and observed for up to 29 weeks post-dose. Safety, PK parameters, thrombin receptor-activating peptide (TRAP)-activated platelet-leukocyte aggregate (PLA) formation, P-selectin inhibition, plasma soluble P-selectin, and anti-drug antibodies were characterized.

Results
Two inclacumab-related treatment-emergent adverse events were reported in 1 participant; no dose-limiting toxicities were observed. Plasma PK parameters were generally dose-proportional, with a terminal half-life of 13 to 17 days. Mean TRAP-activated PLA formation decreased within 3 h from the start of infusion, and inhibition was sustained for ~ 23 weeks. Mean P-selectin inhibition > 90% was observed up to 12 weeks post-dose. The mean ratio of free to total soluble P-selectin decreased rapidly from pre-dose to end of infusion, then increased gradually to 78% of the baseline ratio by week 29. Treatment-emergent anti-drug antibodies were observed in 2 of 15 participants (13%), without apparent impact on safety, PK, or PD.

Conclusions
Inclacumab was well tolerated, with PK as expected for a monoclonal antibody against a membrane-bound target and a long duration of PD effects after both single IV doses, supporting a prolonged dosing interval.

Trial registration
ACTRN12620001156976; registered November 4, 2020.
The role of vaccines in the COVID-19 pandemic: what have we learned?
Authors: Krammer Florian 
Published: July 2023

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged late in 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed approximately 20 million lives. Vaccines were developed quickly, became available in the end of 2020, and had a tremendous impact on protection from SARS-CoV-2 mortality but with emerging variants the impact on morbidity was diminished. Here I review what we learned from COVID-19 from a vaccinologist’s perspective.
Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine
Authors: Esposito Cecilia Maria , De Cagna Francesca , Caldiroli Alice , Capuzzi Enrico , Ceresa Alessandro , Di Paolo Martina , Auxilia Anna Maria , Capellazzi Martina , Tagliabue Ilaria , Cirella Luisa , Clerici Massimo , Brondino Natascia , Barkin Jennifer L. , Politi Pierluigi , Buoli Massimiliano 
Published: July 2023

Abstract
Background
The scientific literature shows some gender differences in the clinical course of schizophrenia. The aim of this study is to identify gender differences in clinical and biochemical parameters in subjects affected by schizophrenia. This would allow for the implementation of individualized treatment strategies.

Methods
We examined a large set of clinical and biochemical parameters. Data were obtained from clinical charts and blood analyses from a sample of 555 schizophrenia patients consecutively admitted for exacerbation of symptoms to the inpatient clinic of Fondazione IRCCS Policlinico (Milan) or ASST Monza in Italy from 2008 to 2021. Univariate analyses, binary logistic regression, and a final logistic regression model were performed with gender as dependent variable.

Results
The final logistic regression models showed that male patients (compared to females) were more prone to lifetime substance use disorders (p = 0.010). However, they also had higher GAF (global functioning) mean scores (p < 0.001) at the time of hospitalization. Univariate analyses showed that male patients (with respect to females) had an earlier age at onset (p < 0.001), a more frequent family history of multiple psychiatric disorders (p = 0.045), were more often smokers (p < 0.001), had a more frequent comorbidity with at least one psychiatric disorder (p = 0.001), and less often suffered from hypothyroidism (p = 0.011). In addition, men had higher levels of albumin (p < 0.001) and bilirubin (t = 2.139, p = 0.033), but lower levels of total cholesterol (t = 3.755, p < 0.001).

Conclusions
Our analyses indicate a less severe clinical profile in female patients. This is evident especially in the early years of the disorder, as suggested by less comorbidity with psychiatric disorders or later age at onset; this is consistent with the related literature. In contrast, female patients seem to be more vulnerable to metabolic alterations as demonstrated by more frequent hypercholesterolemia and thyroid dysfunction. Further studies are needed to confirm these results in the framework of precision medicine.
KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule
Authors: Talbi Khaoula , Ousingsawat Jiraporn , Centeio Raquel , Schreiber Rainer , Kunzelmann Karl 
Published: July 2023

AbstractThe TMEM16A (ANO1) Cl- channel is activated by Ca2+ in a voltage-dependent manner. It is broadly expressed and was shown to be also present in renal proximal tubule (RPT). KCNQ1 is an entirely different K+ selective channel that forms the cardiac IKS potassium channel together with its ß-subunit KCNE1. Surprisingly, KCNE1 has been claimed to interact with TMEM16A, and to be required for activation of TMEM16A in mouse RPT. Interaction with KCNE1 was reported to switch TMEM16A from a Ca22+-dependent to a voltage-dependent ion channel. Here we demonstrate that KCNE1 is not expressed in mouse RPT. TMEM16A expressed in RPT is activated by angiotensin II and ATP in a KCNE1-independent manner. Coexpression of KCNE1 does not change TMEM16A to a voltage gated Cl- channel and Ca2+-dependent regulation of TMEM16A is fully maintained in the presence of KCNE1. While overexpressed KCNE1 slightly affects Ca2+-dependent regulation of TMEM16A, the data provide no evidence for KCNE1 being an auxiliary functional subunit for TMEM16A.
A contemporary assessment of total neoadjuvant therapy (TNT) protocols for locally advanced rectal cancer: adoption and expert perspectives at German Cancer Society (DKG)-certified colorectal cancer centers
Authors: Langheinrich Melanie , Paasch Christoph , Mantke René , Weber Klaus , Benz Stefan , Kersting Stephan 
Published: July 2023

Abstract
Purpose
The treatment paradigm for locally advanced rectal cancer (LARC) is shifting toward the total neoadjuvant therapy (TNT) concept, which administered systemic chemotherapy in the neoadjuvant setting, either before or after chemoradiotherapy (CRT) or short-course radiotherapy (SCRT). First results have shown higher pathologic complete response (pCR) rates and a favorable impact on disease-free survival (DFS). Our study aimed to evaluate the current clinical practice and expert opinion regarding TNT for locally advanced rectal cancer across DKG (German Cancer Society)-certified colorectal cancer centers.

Methods
A comprehensive online questionnaire, constituted of 14 TNT-focused queries targeting patients with locally advanced rectal cancer, was conducted among DKG-certified colorectal cancer centers registered within the database of the Addz (Arbeitsgemeinschaft Deutscher Darmzentren) between December 2022 and January 2023.

Results
A significant majority (68%) indicated that they treated between 0 and 10 patients using a TNT protocol. Only a third (36%) of these centers participated in patient enrollment for a TNT study. Despite this, 84% of centers reported treating patients in a manner analogous to a TNT study, with the RAPIDO regimen being the most prevalent approach, employed by 60% of the respondents. The decision to adopt a TNT approach was primarily influenced by factors, such as the lower third of the rectum (93% of centers), cT4 stage (86% of centers), and a positive circumferential resection margin (80% of centers). Regarding concerns, 65% of the survey respondents expressed no reservations about the TNT concept, while 35% had concerns. In particular, there appears to be disagreement and uncertainty in regard to a clinical complete response and the “Watch and Wait” approach. While some centers adopt the watch-and-wait approach (42%), others only utilize it when extirpation is otherwise necessary (39%), and a portion still proceeds with surgery as initially planned (19%). The survey also addressed unmet needs, which were elaborated in the free-text responses. Overall, there was high interest in participating in planned observational studies.

Conclusions
This study presents an overview of current clinical practice and unmet needs within DKG-certified German colorectal cancer centers. It is noteworthy that total neoadjuvant therapy (TNT) is predominantly performed outside of clinical trials. Moreover, across the centers, there is significant heterogeneity in handling clinical complete response and adopting the “watch and wait” approach. Further research is needed to establish standardization in the care of locally advanced rectal cancer.