bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting Magnesium Ion Storage Behavior via Heteroelement Doping in a Porous Tunnel Framework Cathode for Aqueous Mg‐Ion Batteries
Authors: Li Zhuo , Chen Yuanyuan , Gong Zhe , Liu Yang , Wang Guiling , Gao Yinyi , Zhu Kai , Cao Dianxue 
Published: May 2023

AbstractTo relieve the overwhelming pressure on fossil energy, aqueous magnesium ion batteries attracted tremendous attention owing to their low cost and high safety. However, the cathode materials are apt to occur lattice distortion because of the electrostatic interaction between magnesium ions and crystal. The 2×2 manganese octahedral molecular sieve with potassium ions and water located in the tunnels (K‐OMS‐2), utilized as a cathode material for chargeable magnesium ions batteries, is exposed to irreversible Mg2+ intercalation/deintercalation due to lattice distortion, which heavily damages the electrochemical properties and declines the capacity. Herein, we carry out an ion doping strategy to overcome the above issues, leading to an enhanced Mg Mg2+ storage behavior. The Nb or V cation is successfully doped into K‐OMS‐2 by a facile reflux method under room temperature. The specific surface area is enlarged by the addition of cations, which promise a large electrode‐electrolyte contact area. The Nb and V doped K‐OMS‐2 present a capacity of 252.6 and 265.9 mAh/g at 20 mA/g, respectively. This work demonstrates an ion doping approach toward exploiting the stable and high‐capacity Mg‐ion battery cathode and provides potential cathode materials for a large‐scale aqueous Mg‐ion‐based energy storage system.
Robust output regulation of a non‐uniform Euler‐Bernoulli beam
Authors: Meng Tingting , Huang Haifeng , Wu Xiaoyang , Fu Qiang 
Published: May 2023

AbstractFor an Euler‐Bernoulli beam with variable coefficients, all the disturbances and references are supposed to be from an exosystem. Two observer‐based controls are proposed to regulate two non‐collocated outputs to track prescribed references. First, we construct an uncertain disturbance‐free beam system, which is determined by the inputs, measurable outputs, and unknown initial conditions. New exosystems are then defined to address the undetectability of the original exosystem and the uncertainties of input disturbances. We then propose two observer‐based controls through an extended observer for the disturbance‐free beam and the new exosystems. For the closed‐loop system, the tracking errors are proved to be exponentially regulated toward zero. A simulation example is provided to describe the theoretical result.
Fouling of virus filtration membranes by monoclonal antibody feeds with low aggregate content
Authors: Kaufman Yair , Hunt KC , Hale Gabriel , McClure Matthew , Latulippe David , Sivan Madhavi , Wilson Jack , Dorin Rachel , Agroskin Yury , Siwak Marty , Gerion Daniele 
Published: May 2023

AbstractMembrane fouling by monoclonal antibodies (mAbs) is one of the main challenges in virus‐filtration processes. Previous publications attributed membrane fouling to the presence of mAb aggregates in the solution, which block the membrane pores. This fouling mechanism can be solved by a prefilter; however, it was shown that there are mAbs that severely foul the membranes (reduce permeability by 90% and more) even after prefiltering the aggregates, while other mAbs foul the membrane weakly (reduce permeability by ~10% and less). Unfortunately, the differences between the fouling‐ and the nonfouling mAbs have never been convincingly explained. To get a deeper insight on these differences, we measured the fouling of chemically modified Isoprene‐Styrene‐4‐vinylpyridine (ISV) membranes (TeraPore Technologies) by 8 mAbs exhibiting different hydrophobicity and charge. The results show that mAb solutions with low concentration of aggregates foul ISV membranes via an adsorptive mechanism, and the adsorption is driven mainly by hydrophobic forces between the mAb and the membrane. The charge of the mAbs plays a secondary role in fouling. We want to emphasize that the conclusions pertain to ISV membranes; the insights presented in this paper can potentially be used to engineer new surface chemistries to mitigate fouling of other virus‐filtration and/or ultrafiltration membranes.
Organizational improvisation and corporate green innovation: A dynamic capability perspective
Authors: Chen Lu , Yuan Ming , Lin Han , Han Yilong , Yu Youyou , Sun Caihui 
Published: May 2023

AbstractThe march toward fusing business with sustainability is articulated with the hope of offering solutions to global environmental degradation. Green innovation is often regarded as an effective strategy to induce double externality with positive innovation and environmental spillovers. Despite numerous research works on determinants of green innovation, the key question, however, whether and how organizational improvisation exerts its influence on innovatively being green is still unsolved. On this basis, the current study seeks to demonstrate a connection between organizational improvisation and corporate green innovation. According to the presented theoretical framework, organizational improvisation, which serves as a catalyst for improving learning processes, promotes green innovation. Furthermore, dynamic capabilities mediate this relationship, and top management risk aversion could weaken the successful transformation of substantive innovation and being green. Empirical evidence is found based on a sample of Chinese manufacturing firms with a moderated mediation analysis. These results extend the understanding of the role of improvisation in green achievements towards the fusion of unplanned change and order.
A case report of multimodal ultrasound imaging in the diagnosis of giant retroperitoneal ganglioneuroma
Authors: Feng Li , Wang Yong 
Published: May 2023

AbstractRetroperitoneal ganglioneuroma is a rare benign tumor that is challenging in terms of clinical diagnosis. Computed tomography and magnetic resonance imaging are usually performed for diagnosis rather than convenient and inexpensive ultrasonography. Here, we present the case of a 21‐year‐old female patient who was diagnosed by multimodal ultrasound imaging and whose diagnosis was confirmed by ultrasound‐guided core needle biopsy before surgery. We hope that this rare case will help clinicians and radiologists realize the advantages of multimodal ultrasound imaging in the diagnosis of retropeitoneal solid tumors, and reduce misdiagnosis.
Biomarkers and factors in small cell lung cancer patients treated with immune checkpoint inhibitors: A meta‐analysis
Authors: Li Lin‐Lu , Yu Cheng‐Feng , Xie Hong‐Ting , Chen Zheng , Jia Bo‐Hui , Xie Fei‐Yu , Cai Ya‐Fang , Xue Peng , Zhu Shi‐Jie 
Published: May 2023

AbstractObjectiveThe aim of this meta‐analysis was to summarize the available results of immunotherapy predictors for small cell lung cancer (SCLC) and to provide evidence‐based information for their potential predictive value of efficacy.MethodsWe searched PubMed, EMBASE, Web of Science, The Cochrane Library, and ClinicalTrials (from January 1, 1975 to November 1, 2021). The hazard ratios (HR) and its 95% confidence intervals (CIs) and tumor response rate of the included studies were extracted.ResultsEleven studies were eventually included and the pooled results showed that programmed cell death ligand 1 (PD‐L1) positive: objective response rate (ORR) (relative risk [RR] = 1.39, 95% CI [0.48, 4.03], p = 0.54), with high heterogeneity (p = 0.05, I2 = 56%); disease control rate [DCR] (RR = 1.31, 95% CI [0.04, 38.57], p = 0.88), with high heterogeneity (p = 0.04, I2 = 75%); overall survival (OS) (HR = 0.89, 95% CI [0.74, 1.07], p = 0.22); and progression‐free survival (PFS) (HR = 0.83, 95% CI [0.59, 1.16], p = 0.27), with high heterogeneity (p = 0.005, I2 = 73.1%). TMB‐High (TMB‐H): OS (HR = 0.86, 95% CI [0.74, 1.00], p = 0.05); PFS (HR = 0.71, 95% CI [0.6, 0.85], p < 0.001). Lactate dehydrogenase (LDH) >upper limit of normal (ULN): OS (HR = 0.95, 95% CI [0.81, 1.11], p = 0.511). Asian patients: OS (HR = 0.87, 95% CI [0.72, 1.04], p = 0.135); White/Non‐Asian patients: OS (HR = 0.83, 95% CI [0.76, 0.90], p < 0.001). Liver metastasis patients: OS (HR = 0.93, 95% CI [0.83, 1.05], p = 0.229); PFS (HR = 0.84, 95% CI [0.67, 1.06], p = 0.141). Central nervous system (CNS) metastasis patients: OS (HR = 0.91, 95% CI [0.71, 1.17], p = 0.474); PFS (HR = 1.03, 95% CI [0.66, 1.60], p = 0.903).ConclusionThe available research results do not support the recommendation of PD‐L1 positive and TMB‐H as predictors for the application of immune checkpoint inhibitors (ICIs) in SCLC patients. LDH, baseline liver metastasis and CNS metastasis may be used as markers/influencing factors for predicting the efficacy of ICIs in SCLC patients. Non‐Asian SCLC patients had better efficacy with ICIs in our results.
Efficacy and toxicity of CLAG combined with pegylated liposomal doxorubicin in the treatment of refractory or relapsed acute myeloid leukemia
Authors: Yao Han , Zhang Cheng , Tan Xu , Li Jieping , Yin Xiaolin , Deng Xiaojuan , Chen Ting , Rao Jun , Gao Lei , Kong Peiyan , Zhang Xi 
Published: May 2023

AbstractBackgroundRefractory and relapsed acute myeloid leukemia (r/rAML) is associated with a difficult prognosis; clinical trials are typically suggested despite lack of a recognized standard of care. Combinatorial chemotherapy regimens utilized for r/rAML salvage play a crucial role in battling this invasive phase. Although it is characterized by a low response rate, CLAG is a traditional regimen used in r/rAML. We aimed to compare the efficacy and toxicity of CLAG+PLD to explore whether there was any improvement with the addition of pegylated liposomal doxorubicin (PLD) to CLAGMethodsA total of 110 r/rAML patients were retrospectively analyzed from February 2017 to June 2020 at the Medical Center of Hematology, XinQiao Hospital, the 303rd Hospital of the Chinese People's Liberation Army, and Central Hospital of Chang Sha, Hunan Province. The response, overall survival (OS), disease‐free survival (DFS), and side effects in 110 r/rAML patients were evaluated retrospectively. Of these, 55 patients were administered CLAG+PLD, while 55 patients received CLAG alone as salvage therapy.ResultsIn the CLAG+PLD group, there were 27 (49.1%) cases of complete response (CR) with no measurable residual disease (MRD−), 12 (21.8%) cases of CR with positive MRD (MRD+), 5 (9.1%) cases of partial response (PR), 11 (20%) cases of no response (NR), and no cases of death during the cycles. The response rates in the CLAG group were lower: CR was reached in 24 (46.6%) patients with MRD−, 6 (10.9%) patients with MRD+, 10 (18.2%) patients with PR, 13 (23.6%) patients with NR, and 2 (3.6%) patients who passed away, one from infection and the other from cerebral hemorrhage. The median OS and DFS were not attained in the CLAG+PLD group during the 2‐year OS and DFS follow‐up, while both values were 10 months in the CLAG group (p = 0.023 and p = 0.045, respectively). The results of the Cox regression analysis for the CLAG+PLD group were strongly illustrative of the importance of hematopoietic stem cell transplantation (HSCT) following salvage therapy. No increased toxicity was observed in the CLAG+PLD group.ConclusionCLAG+PLD is a potential salvage regimen for r/r AML that has a similar toxicity profile to CLAG and that improves response rates, 2‐year OS, and DFS relative to CLAG.
Primary malignant melanoma of the cervix: A comprehensive analysis of case reports in the Chinese population
Authors: Ye Yuan , Fu Aizhen , Cai Jiayi , Ma Zhen , Chen Yumei , Zou Xinxin , Li Huiyi , Chen Yongfeng , Zhao Shibo , Chen Caiyun 
Published: May 2023

AbstractPurposeMalignant melanoma is a tumor generated from the basal melanocytes of human epidermis. Primary malignant melanoma of the cervix (PMMC) is derived from cervical melanocytes. It is an uncommon disease, mostly occurring in perimenopausal women. PMMC has a bad prognosis and lacks a defined protocol or treatment standards. The aim of this study was to analyze the impact of different surgical procedures and different adjuvant treatment modalities on their prognosis and to find risk factors for their prognosis by integrating published case report data based on the Chinese population.Methods and ResultsThis study included 165 patients with PMMC in the Chinese population. We used the Kaplan‐Meier method to build the survival curve, and the log‐rank test to examine the variations among the subgroups. Prognostic factors were examined utilizing the Cox proportional hazards regression model. We found that patients who underwent radical hysterectomy‐based surgery, those who underwent lymphadenectomy, and those who underwent other treatments in addition to surgery had significantly better survival rates. The overall analysis, showed that age, and FIGO Stage II, III, and IV, increased the risk of death. Moreover, radical hysterectomy (RH), total hysterectomy (TAH), lymphadenectomy, and adjuvant therapy were correlated with a decreased mortality risk.ConclusionAfter summarizing the current data, we recommend radical hysterectomy, and lymphadenectomy treatment for patients with PMMC. For patients who had already undergone surgery, other treatment options had a positive effect on prognosis. For patients who had already undergone surgery, other treatment options had a positive effect on prognosis; therefore patient‐specific treatment options need to be further discussed.
Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations
Authors: Sato Tatsuhiro , Akao Ken , Sato Ayuko , Tsujimura Tohru , Mukai Satomi , Sekido Yoshitaka 
Published: May 2023

AbstractBackgroundMesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characterized by a high frequency of mutations in a set of genes involved in the Hippo pathway, such as NF2 and LATS2. However, a rapid, simple, and precise method for finding mesothelioma with these mutations has not yet been established.MethodsClustering of Hippo pathway gene alteration groups and the differential expression of each gene in mesothelioma patients were analyzed using The Cancer Genome Atlas database. Gene expression levels in various tumors and normal tissues were analyzed using public databases. Knockdown or transient expression of YAP1 or TAZ was performed to evaluate the regulation of gene expression by these genes. NT‐proBNP was measured in the pleural effusions of 18 patients and was compared with NF2 expression in five cases where cell lines had been successfully established.ResultsNPPB mRNA expression was markedly higher in the group of mesothelioma patients with Hippo pathway gene mutations than in the group without them. NPPB expression was low in all normal tissues except heart, and was highest in mesothelioma. Mesothelioma patients in the high NPPB expression group had a significantly worse prognosis than those in the low NPPB expression group. NPPB expression was suppressed by knockdown of YAP1 or TAZ. NT‐proBNP was abundant in the effusions of mesothelioma patients and was particularly high in those with impaired NF2 expression.ConclusionsNPPB, whose levels can be measured in pleural effusions of mesothelioma patients, has the potential to act as a biomarker to detect NF2‐Hippo pathway gene alterations and/or predict patient prognosis. Additionally, it may provide useful molecular insights for a better understanding of mesothelioma pathogenesis and for the development of novel therapies.
Use of high‐flow nasal cannula oxygen therapy for patients with terminal cancer at the end of life
Authors: Kim Jung Sun , Shin Jeongmi , Kim Nam Hee , Lee Sun Young , Yoo Shin Hye , Keam Bhumsuk , Heo Dae Seog 
Published: May 2023

AbstractBackgroundFew studies have focused on high‐flow nasal cannula (HFNC) usage in the last few weeks of life. The aim of this study was to identify the status of HFNC use in patients with cancer at the end of life and the relevant clinical factors.MethodsWe performed a retrospective cohort study in a tertiary hospital in the Republic of Korea. Among patients with cancer who died between 2018 and 2020, those who initiated HFNC within 14 days before death were included. Patients were categorized based on the time from HFNC initiation to death as imminent (<4 days) and non‐imminent (≥4 days).ResultsAmong the 2191 deceased patients with terminal cancer, 329 (15.0%) were analyzed. The median age of the patients was 66 years, and 62.9% were male. The leading cause of respiratory failure was pneumonia (70.2%), followed by pleural effusion (30.7%) and aggravation of lung neoplasms (18.8%). Most patients were conscious (79.3%) and had resting dyspnea (76.3%) at HFNC initiation. Patients received HFNC therapy for a mean of 3.4 days in the last 2 weeks of life, and 62.6% initiated it within 4 days before death. Furthermore, female sex, no palliative care consultation, no advance statements in person on life‐sustaining treatment, and no resting dyspnea were independently associated with the imminent use of HFNC.ConclusionsMany patients with cancer started HFNC therapy at the point of imminent death. However, efforts toward goal‐directed use of HFNC at the end‐of‐life stage are required.
A qualitative study of the perspectives of designated safeguarding leads responding to child protection concerns in fee‐paying schools
Authors: Bernard Claudia , Greenwood Tom , Henri Tom 
Published: May 2023

AbstractThis article explores the experiences and perspectives of designated safeguarding leads (DSL) in fee‐paying schools to better understand how they engage affluent parents when there are safeguarding and child protection concerns. The research employed a roundtable data gathering methodology, with 33 DSLs from a range of fee‐paying schools in southern England participating in the study. A primary objective of the research was to understand the factors that influence how DSLs in fee‐paying schools engage parents from affluent backgrounds. The findings showed that a major concern is that affluent parents are adept at using their power and privilege to avoid statutory interventions, which meant that the DSLs' safeguarding role was often fraught with difficulties. This article addresses factors that enable or hinder DSLs' conversations with affluent parents and offers some critical reflections on the challenges posed for their duty to safeguard the children in their care. For the purpose of this article, three key themes will be addressed: the interpretation of harm thresholds; communication issues; and mental health issues. Overall, the analysis contributes to a greater understanding of how DSLs in fee‐paying schools navigate their engagement with parents when familial risks are identified.
Persistent oral mucosal lesions preceding diagnosis of Crohn's disease and primary sclerosing cholangitis
Authors: Nylund Karita , Helenius‐Hietala Jaana , Åberg Fredrik , Hagström Jaana , Ruokonen Hellevi 
Published: May 2023

AbstractOral mucosal lesions may persist years before symptoms or diagnosis of inflammatory bowel disease (IBD) and subsequent primary sclerosing cholangitis (PSC). Since a dental practitioner may be the first clinician to suspect IBD with extraintestinal manifestations (EIMs), early referral, and close collaboration with a gastroenterologist are recommended.
Protein‐losing enteropathy as the first presentation of systemic lupus erythematosus: A case report from Sudan
Authors: Abdalla Elham , Mohymeed Noon , Nail Abdelsalam M. A. , Tonga Rayan Ali , Alfatih Mohammed , Abdalfdeel Almahie Shaban Mohannad , Eltoum Hassan 
Published: May 2023

Key Clinical MessageIn low‐ and middle‐income countries, protein‐losing enteropathy is a diagnosis of exclusion. SLE should be on the list of differential diagnoses of protein‐losing enteropathy, especially if the patient had a long history of GI symptoms and ascites.AbstractProtein‐losing enteropathy can rarely be the initial presentation of systemic lupus erythematosus (SLE). Protein‐losing enteropathy is a diagnosis of exclusion in low‐ and middle‐income countries. Protein‐losing enteropathy in SLE should be in the list of differential diagnosis of unexplained ascites, especially if patient had long history of gastrointestinal symptoms. We present a case of 33 years old male with long standing gastrointestinal symptoms and diarrhea attributed previously to irritable bowel syndrome. Presented with progressive abdominal distension, and diagnosed with ascites. Workup for him showed leucopenia, thrombocytopenia, hypoalbumenemia, elevated inflammatory markers (ESR 30, CRP 6.6), high cholesterol level (306 mg/dL), normal renal profile and normal urine analysis. Ascitic tab pale yellow with SAAG 0.9 and positive for adenosine deaminase (66 u/L) sugesstive for tuberculous peritonitis although quantitative PCR and geneXpert for MBT was negative. Antituberculous treatment was started and his condition deteriorated, immediately antituberculous was withdrawal. Further tests revealed positive serology for ANA (1:320 speckled pattern) with positive anti‐RNP/Sm, positive anti‐Sm antibodies. Complements level were normal. He started immunosuppressive therapy (prednisolone 10 mg/day, hydroxychloroquine 400 mg/day, azathioprine 100 mg/day). In addition, his condition is improved Diagnosis was made as SLE with Protein‐losing enteropathy based on hypoalbumenemia (with exclusion of renal loss of protein), ascites, hypercholesrtolemia and exclusions of other mimics as explained later. As well as positive response to immunosuppressive medications. Our patient diagnosed clinically as SLE with protein‐losing enteropathy. Protein‐losing enteropathy in SLE is challenging in diagnosis because of its rarity as well as limitations in its diagnostic tests.
A case of TAFRO syndrome with DIC and neurologic and cardiac involvement
Authors: Moy Lindsay N. , Patel Mauli , Eschbach Josiah , Knouse Phillip , Gálvez Ángel 
Published: May 2023

Key Clinical MessageWe highlight a novel case of TAFRO syndrome with disseminated intravascular coagulation, neurologic changes, and non‐ischemic cardiomyopathy. Through this clinical vignette, we hope to raise awareness of TAFRO syndrome and encourage providers to maintain a high level of suspicion for it when evaluating patients who meet the diagnostic criteria.
Light‐Promoted Germylation of Aryl Propiolamides/Alkynoates: Synthesis of Ge‐Containing Spiro[4.5]trienones and Vinylgermanes
Authors: Luo Yani , Lv Leiyang , Li Zhiping 
Published: May 2023

AbstractThe light‐promoted regioselective germylation of aryl propiolamides/alkynoates with germanium hydrides is reported. The germyl‐containing spiro[4.5]trienones were obtained when N‐arylpropiolamides were used via sequential C−Ge and C−C bond formation, while aryl alkynoates delivered the vinylgermanes with radical Smiles rearrangement and CO2 release.