bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological defects in silicene
Authors: Kosarev I. V. , Kistanov A. A. , Babicheva R. I. , Korznikova E. A. , Baimova J. A. , Dmitriev S. V. 
Published: February 2023

Abstract
Using the molecular dynamic simulations a new class of topological defects in silicene is investigated. Si atoms in silicene belong to two triangular sublattices shifted one with respect to the other by h along the direction normal to the sheet. Silicene can have two energetically equivalent structures when the first or second sublattice is above the other. Topological defects appear at the junctions of the domains of these two structures. Domain walls can be rectilinear or curvilinear. Such defects cannot disappear from the structure except as a result of the annihilation of defects with positive and negative topological charges. Structure and energy of the topological defects are calculated. The effect of temperature is shown. Similar defects inevitably exist in other group IVA elemental 2D materials with buckled structure, such as germanene, stanene, and plumbene. As a result of the work, the problem of experimental detection of such defects and the question of how they affect the physicochemical and mechanical properties of materials, in particular, toxicity or sensory properties, is posed.
Frailty Measured by the Risk Analysis Index Predicts Nonhome Discharge and Mortality After Resection in Refractory Epilepsy: Analysis of 1236 Patients From a Prospective Surgical Registry, 2012 to 2020
Authors: Estes Emily M. , Rumalla Kavelin , Kazim Syed Faraz , Kassicieh Alexander J. , Segura Aaron C. , Kogan Michael , Spader Heather S. , Botros James A. , Schmidt Meic H. , Sheehan Jason P. , McKee Rohini G. , Shin Hae Won , Bowers Christian A. 
Published: February 2023

BACKGROUND:Risk stratification of epilepsy surgery patients remains difficult. The Risk Analysis Index (RAI) is a frailty measurement that augments preoperative risk stratification.OBJECTIVE:To evaluate RAI's discriminative threshold for nonhome discharge disposition (NHD) and mortality (or discharge to hospice within 30 days of operation) in epilepsy surgery patients.METHODS:Patients were queried from the American College of Surgeons-National Surgical Quality Improvement Program database (2012-2020) using diagnosis/procedure codes. Linear-by-linear trend tests assessed RAI's relationship with NHD and mortality. Discriminatory accuracy was assessed by C-statistics (95% CI) in receiver operating characteristic curve analysis.RESULTS:Epilepsy resections (N = 1236) were grouped into temporal lobe (60.4%, N = 747) and nontemporal lobe (39.6%, N = 489) procedures. Patients were stratified by RAI tier: 76.5% robust (RAI 0-20), 16.2% normal (RAI 21-30), 6.6% frail (RAI 31-40), and 0.8% severely frail (RAI 41 and above). The NHD rate was 18.0% (N = 222) and positively associated with increasing RAI tier: 12.5% robust, 34.0% normal, 38.3% frail, and 50.0% severely frail (P< .001). RAI had robust predictive discrimination for NHD in overall cohort (C-statistic 0.71), temporal lobe (C-statistic 0.70), and nontemporal lobe (C-statistic 0.71) cohorts. The mortality rate was 2.7% (N = 33) and significantly associated with RAI frailty: 1.1% robust, 8.0% normal, 6.2% frail, and 20.0% severely frail (P< .001). RAI had excellent predictive discrimination for mortality in overall cohort (C-statistic 0.78), temporal lobe (C-statistic 0.80), and nontemporal lobe (C-statistic 0.74) cohorts.CONCLUSION:The RAI frailty score predicts mortality and NHD after epilepsy surgery. This is accomplished with a user-friendly calculator: https://nsgyfrailtyoutcomeslab.shinyapps.io/epilepsy/.
Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development
Authors: Ramiro-Pareta Marina , Müller-Sánchez Claudia , Portella-Fortuny Rosa , Soler-Botija Carolina , Torres-Cano Alejo , Esteve-Codina Anna , Bayés-Genís Antoni , Reina Manuel , Soriano Francesc X. , Montanez Eloi , Martínez-Estrada Ofelia M. 
Published: February 2023

ABSTRACT
Wt1 encodes a zinc finger protein that is crucial for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly attributed to its functions in the epicardium. Here, we have generated an inducible endothelial-specific Wt1 knockout mouse model (Wt1KOΔEC). Deletion of Wt1 in ECs during coronary plexus formation impaired coronary blood vessels and myocardium development. RNA-Seq analysis of coronary ECs from Wt1KOΔEC mice demonstrated that deletion of Wt1 exerted a major impact on the molecular signature of coronary ECs and modified the expression of several genes that are dynamically modulated over the course of coronary EC development. Many of these differentially expressed genes are involved in cell proliferation, migration and differentiation of coronary ECs; consequently, the aforementioned processes were affected in Wt1KOΔEC mice. The requirement of WT1 in coronary ECs goes beyond the initial formation of the coronary plexus, as its later deletion results in defects in coronary artery formation. Through the characterization of these Wt1KOΔEC mouse models, we show that the deletion of Wt1 in ECs disrupts physiological blood vessel formation.
Surgical Oncologists and Nurses in Breast Cancer Care are Ready to Provide Pre-Test Genetic Counseling
Authors: Bokkers K. , Bleiker E. M. A. , Aalfs C. M. , van Dalen T. , Velthuizen M. E. , Duijveman P. , Sijmons R. H. , Koole W. , Schoenmaeckers E. J. P. , Ausems M. G. E. M. 
Published: February 2023

AbstractBackgroundPre-test genetic counseling for patients with breast cancer is increasingly being provided by nongenetic healthcare professionals. We evaluated the attitudes, knowledge, and self-efficacy of surgeons, oncologists, and nurses regarding mainstream genetic testing and the feasibility to incorporate pre-test genetic counseling into routine care.MethodsWe offered an online training to healthcare professionals from 13 hospitals and implemented a mainstream genetic testing pathway in 11/13 (85%) hospitals. Questionnaires were sent before (T0) and 6 months after (T1) completing the training. Those who did not complete the training received a questionnaire to assess their motivations.ResultsIn 11 hospitals, 80 (65%) healthcare professionals completed the training, of whom 70 (88%) completed both questionnaires. The attitudes, (perceived) knowledge and self-efficacy of healthcare professionals were high both at baseline and 6 months after completing the training. After 6 months, their perceived knowledge about the advantages and disadvantages of a genetic test and implications for family members had significantly improved (p = 0.012 andp = 0.021, respectively). For the majority (89%), the time investment for pre-test genetic counseling was less than 15 min per patient and as expected or better. Healthcare professionals considered the total time investment feasible to incorporate mainstream genetic testing into their daily practice. The main barrier to complete the training was lack of time. The online training was considered useful, with a rating of 8/10.ConclusionSurgical oncologists and nurses in breast cancer care feel well-equipped and motivated to provide pre-test genetic counseling after completion of an online training module.
Assessing the implementation of COVID-19 structured reporting templates for chest radiography: a scoping review
Authors: O'Reilly Peter A , Lewis Sarah , Reed Warren 
Published: February 2023

Objective: One of the common modalities used in imaging COVID-19 positive patients is chest radiography (CXR), and serves as a valuable imaging method to diagnose and monitor a patients’ condition. Structured reporting templates are regularly used for the assessment of COVID-19 CXRs and are supported by international radiological societies. This review has investigated the use of structured templates for reporting COVID-19 CXRs. Methods: A scoping review was conducted on literature published between 2020 and 2022 using Medline, Embase, Scopus, Web of Science, and manual searches. An essential criterion for the inclusion of the articles was the use of reporting methods employing either a structured quantitative or qualitative reporting method. Thematic analyses of both reporting designs were then undertaken to evaluate utility and implementation. Results: Fifty articles were found with the quantitative reporting method used in 47 articles whilst 3 articles were found employing a qualitative design. Two quantitative reporting tools (Brixia and RALE) were used in 33 studies, with other studies using variations of these methods. Brixia and RALE both use a posteroanterior or supine CXR divided into sections, Brixia with six and RALE with four sections. Each section is scaled numerically depending on the level of infection. The qualitative templates relied on selecting the best descriptor of the presence of COVID-19 radiological appearances. Grey literature from 10 international professional radiology societies were also included in this review. The majority of the radiology societies recommend a qualitative template for reporting COVID-19 CXRs. Conclusion: Most studies employed quantitative reporting methods which contrasted with the structured qualitative reporting template advocated by most radiological societies. The reasons for this are not entirely clear. There is also a lack of research literature on both the implementation of the templates or comparing both template types, indicating that the use of structured radiology reporting types may be an underdeveloped clinical strategy and research methodology. Advances in knowledge: This scoping review is unique in that it has undertaken an examination of the utility of the quantitative and qualitative structured reporting templates for COVID-19 CXRs. Moreover, through this review, the material examined has allowed a comparison of both instruments, clearly showing the favoured style of structured reporting by clinicians. At the time of the database interrogation, there were no studies found had undertaken such examinations of both reporting instruments. Moreover, due to the enduring influence of COVID-19 on global health, this scoping review is timely in examining the most innovative structured reporting tools that could be used in the reporting of COVID-19 CXRs. This report could assist clinicians in decision-making regarding templated COVID-19 reports.
Quality parameters for RNA preparations from biopsies of ulcerated human skin
Authors: Giraldo-Parra Lina , Ramirez Lady Giovanna , Navas Adriana , Gómez María Adelaida 
Published: February 2023

Background: Obtaining high quality RNA from skin biopsies is complex due the physical composition and high content of nucleases of this tissue. This becomes particularly challenging when using compromised skin samples with necrotic, inflammed or damaged areas, such as those from patients suffering skin conditions, which affect more than 900 million people annually. We evaluated the impact of the biopsy size and tissue preservation method on the quality and quantity of RNA extracts. Methods: Skin lesion biopsies were obtained from patients with cutaneous leishmaniasis (CL). Biopsy specimens of 2 mm (n = 10) and 3 mm (n = 59) were preserved in Allprotect® reagent, and 4 mm biopsies in OCT (n = 54). Quality parameters were evaluated using Nanodrop and Bioanalyzer. The informativeness of the extracted samples for downstream analyses was evaluated using RT-qPCR and RNA-Seq. Results: The success rate, based on quality parameters of RNA extraction from tissue biopsies stored in OCT and 2 mm biopsies stored in Allprotect®, was 56% (30/54) and 30% (3/10), respectively. For 3 mm skin biopsies stored in Allprotect® was 93% (55/59). RNA preparations from 3 mm-Allprotect® biopsies had an average RIN of 7.2 ± 0.7, and their integrity was not impacted by sample storage time (up to 200 days at -20°C). RNA products were appropriate for qRT-PCR and RNA-seq. Based on these results, we propose a standardized method for RNA extraction from disrupted skin samples. This protocol was validated with lesion biopsies from CL patients (n = 30), having a success rate of 100%. Conclusions: Our results indicate that a biopsy size of 3 mm in diameter and preservation in Allprotect® for up to 200 days at -20°C, are best to obtain high quality RNA preparations from ulcerated skin lesion biopsy samples.
Dual-wavelength laser source by spectral beam combining of two Nd:YAG pulse lasers
Authors: Zhu Zhanda , Wu Weichong , Wang Luda , Hui Yongling , Lei Hong , Li Qiang 
Published: February 2023

We present a dual-wavelength laser source obtained by spectral beam
combining of two solid-state Nd:YAG pulsed lasers. The central
wavelengths were locked at 1061.5 and 1064.6 nm. The output
energy was the sum of the energy of the individually locked Nd:YAG
lasers. The beam quality M2 of the combined beam is 2.8×2.2, which is nearly the same as that of
a single Nd:YAG laser beam. This work should be helpful to provide an
effective dual-wavelength laser source for applications.
Polarized light diffuse reflectance FT-NIR MEMS spectrometer enabling the detection of powder samples through a thin plastic layer
Authors: Eltagoury Yomna M. , Sabry Yasser M. , Khalil Diaa 
Published: February 2023

Polarized scattered light Fourier transform infrared (FTIR) spectroscopy is used for measuring the absorbance of highly scattering materials overcoming the multiple scattering effect. It has been reported for in vivo for biomedical applications and in-field for agricultural and for environmental monitoring. In this paper, we report a polarized light microelectromechanical system (MEMS)-based FTIR in the extended near infrared (NIR) that utilizes a bistate polarizer in a diffuse reflectance measurement setup. The spectrometer is capable of distinguishing between single backscattering from the uppermost layer and multiple scattering from the deep layers. The spectrometer has a spectral resolution of 64cm−1 (about 16 nm at a wavelength of 1550 nm) and operates in the spectral range of 4347cm−1 to 7692cm−1 (1300 nm to 2300 nm). The technique implies de-embedding of the MEMS spectrometer polarization response by normalizing its effect; this is applied on three different samples: milk powder, sugar, and flour in plastic bags. The technique is examined on different scattering size particles. The scattering particles diameter’s range is expected to vary from 10 µm to 400 µm. The absorbance spectra of the samples are extracted and compared to the direct diffuse reflectance measurements of the samples, showing good agreement. By using the proposed technique, the calculated error for the flour was decreased from 43.2% to 2.9% at 1935 nm wavelength. The wavelength error dependence is also reduced.
Psychiatric medications and the risk of autoimmune and immune-mediated inflammatory diseases: A systematic review and meta-analysis of observational studies
Authors: Larivuo Ilmari , Laukkala Heidi , Nevalainen Anna , Arponen Otso , Nevalainen Olli P. O. 
Published: February 2023

Background
Pharmacovigilance reports have suggested that certain commonly used medications may trigger autoimmune diseases (ADs) and immune-mediated inflammatory diseases (IMIDs). We systematically reviewed the literature to evaluate whether psychiatric medication use is associated with ADs and IMIDs.

Methods
The protocol was registered in PROSPERO (CRD42022296524) before the start of the study. We searched Medline Ovid and Scopus up to November 28th, 2021, for comparative studies, with any psychiatric medication as exposure and ADs and IMIDs as outcomes. Meta-analysis was performed using DerSimonian-Laird random-effects modeling. The PRISMA 2020 guidelines were followed in reporting. Study-level risk of bias was assessed using the Newcastle-Ottawa Scale, and the overall certainty of evidence using GRADE.

Results
There were 7,265 citations from which 31 studies were eligible, all from high-income countries, covering 15 distinct immune diseases. The evidence for the association between selective serotonin reuptake inhibitor (SSRI) use and higher risk of microscopic colitis (meta-OR 2.60, 95% CI 1.05–6.39, I2 97.5%, 6 studies) was of low certainty. A subgroup analysis by the histological type of microscopic colitis showed a statistically significant association only with lymphocytic colitis (meta-OR 2.88, 95% CI 2.60–3.18, I2 00.00%, three studies). In two case-control studies, SSRI use had no significant association with psoriasis (meta-OR 0.80, 95% CI 0.58–1.10, I2 82.4%). The risk of acute pancreatitis was slightly increased with exposure to SSRIs (meta-OR 1.13, 95% CI 1.01–1.26, I2 00.0%), as was the risk of bullous pemphigoid after exposure to antipsychotics (meta-OR 1.79, 95% CI 1.17–2.73, I2 0%).

Conclusions
We reviewed the literature on whether psychiatric medications associate with the risk of ADs and IMIDs and concluded that, despite several signals, the credibility of evidence remains low at best. Prospective cohort studies would be needed as the next step to confirm the suggestions of increased risk.
Effectiveness of psychosocial interventions for infertile women: A systematic review and meta-analysis with a focus on a method-critical evaluation
Authors: Kremer Franziska , Ditzen Beate , Wischmann Tewes 
Published: February 2023

BackgroundApproximately seven to nine percent of couples of reproductive age do not get pregnant despite regular and unprotected sexual intercourse. Various psychosocial interventions for women and men with fertility disorders are repeatedly found in the literature. The effects of these interventions on outcomes such as anxiety and depression, as well as on the probability of pregnancy, do not currently allow for reliable generalisable statements. This review includes studies published since 2015 performing a method-critical evaluation of the studies. Furthermore, we suggest how interventions could be implemented in the future to improve anxiety, depression, and pregnancy rates.MethodThe project was registered with Prospero (CRD42021242683 13 April 2021). The literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Six databases were searched and 479 potential studies were discovered. After reviewing the full texts, ten studies were included for the synthesis. Not all studies reported the three outcomes: four studies each for depression, three for anxiety and nine studies for pregnancy rates were included in the meta-analysis, which was conducted using the Comprehensive meta-analysis (CMA) software.ResultsPsychosocial interventions do not significantly change women’s anxiety (Hedges’ g -0,006; CI: -0,667 to 0,655; p = 0,985), but they have a significant impact on depression in infertile women (Hedges’ g -0,893; CI: -1,644 to -0,145; p = 0,026). Implementations of psychosocial interventions during assisted reproductive technology (ART) treatment do not increase pregnancy rates (odds ratio 1,337; 95% CI 0,983 to 1,820; p = 0,064). The methodological critical evaluation indicates heterogeneous study design and samples. The results of the studies were determined with different methods and make comparability difficult. All these factors do not allow for a uniform conclusion.Methodological critical evaluationStudy design (duration and timing of intervention, type of intervention, type of data collection) and samples (age of women, reason for infertility, duration of infertility) are very heterogeneous. The results of the studies were determined with different methods and make comparability difficult. All these factors do not allow for a uniform conclusion.ConclusionIn order to be able to better compare psychosocial interventions and their influence on ART treatment and thus also to achieve valid results, a standardised procedure to the mentioned factors is necessary.
Social Network Diversity and the Daily Burden of Inflammatory Bowel Disease
Authors: Greene-Higgs LaVana , Jordan Ariel , Sheehan Jessica , Berinstein Jeffrey , Admon Andrew J. , Waljee Akbar , Riehl Megan , Piette John , Resnicow Kenneth , Higgins Peter , Cohen-Mekelburg Shirley 
Published: February 2023

Abstract

Objectives:
To examine the association between social network, daily IBD burden, and related cognitive factors such as loneliness and psychological well-being.

Methods:
Using survey data, we compared the relationship between social network diversity and daily IBD burden with multivariable linear regression.

Results:
Patients with IBD with higher social network diversity reported a lower daily IBD burden. This association was more common among those who reported a higher degree of loneliness than those with a low degree of loneliness.

Conclusions:
We should consider diverse social connections as an indicator of risk for higher IBD burden, especially among lonely patients.
Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk from 5 Prospective Cohorts
Authors: Lee Alice A. , Wang Qiao-Li , Kim Jihye , Babic Ana , Zhang Xuehong , Perez Kimberly , Ng Kimmie , Nowak Jonathan , Rifai Nader , Sesso Howard D. , Buring Julie E. , Anderson Garnet L. , Wactawski-Wende Jean , Wallace Robert , Manson JoAnn E. , Giovannucci Edward L. , Stampfer Meir J. , Kraft Peter , Fuchs Charles S. , Yuan Chen , Wolpin Brian M. 
Published: February 2023

BACKGROUND:

Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa.

METHODS:
We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for pancreatic cancer. ABO blood type was assessed using genetic polymorphisms at the ABO gene locus or self-report.

RESULTS:
Compared to H. pylori seronegative participants, those who were seropositive did not demonstrate an increased risk for pancreatic cancer (OR 0.83, 95% CI 0.65-1.06). This lack of association was similar among CagA seropositive (OR 0.75, 95% CI 0.53-1.04) and seronegative (OR 0.89, 95% CI 0.65-1.20) participants. The association was also similar when stratified by time between blood collection and cancer diagnosis (P-interaction=0.80). Consistent with prior studies, non-O blood type was associated with increased pancreatic cancer risk, but this increase in risk was similar regardless of H. pylori seropositivity (P-interaction=0.51).

DISCUSSION:
In this nested case-control study, history of H. pylori infection as determined by H. pylori antibody serology was not associated with pancreatic cancer risk, regardless of CagA virulence factor status. The elevated risk associated with non-O blood type was consistent in those with or without H. pylori seropositivity.