bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethics’ power dynamics in higher education’s self-ethnographic research
Authors: Madikizela-Madiya Nomanesi 
Published: March 2023

Purpose
The purpose of this paper is to highlight levels of power in research ethics that are insufficiently addressed in self-ethnographic research literature.

Design/methodology/approach
The paper reflexively draws from a qualitative research that was conducted in a higher education institution (HEI) in South Africa. The reflection is substantiated with literature on various aspects of the reflection. The research design was self-ethnography, conducted within a postmodernist paradigm.

Findings
The reflection exposes the hidden levels of power in the process of ethical clearance and gatekeeping of access to participants. It also suggests that different theoretical perspectives about ethics work together throughout the self-ethnographic research process.

Research limitations/implications
The research on which the paper is based was conducted in only one college of one HEI. Therefore its findings may only be contextual.

Practical implications
The exposure of the levels of power contributes to the discourses of research ethics and may caution self-ethnographic researchers about the complexities of research ethics involved in this research design.

Originality/value
Although there is plethora of literature about ethics and insider research, little has been done to bring to light the various levels of power that this paper highlights.
Walking in indeterminate spaces: possibilities for political co-existence
Authors: Phillips Louise Gwenneth 
Published: March 2023

Purpose
The purpose of this paper is to discuss how being led by a young child to unknown destinations without shared language offers an experience of indeterminacy that opens up (re)thinking of political co-existence.

Design/methodology/approach
The relational arts project The Walking Neighbourhood hosted by children challenges the social practice of adults chaperoning children through public streets by inviting children to curate and lead unknown adults on walks of local neighbourhoods. This paper focusses on sensory ethnographic research of one encounter of a child-curated walk when this project took place in Chiang Mai, Thailand. The experience is relayed through multilayered sensorial storytelling inter-woven with diffractive analysis informed from a post-humanist agential realist position (Barad, 2007, 2012).

Findings
Perceptions, knowings, imaginings, memories and connections are read as explanations of intra-actions in the child-led walk to produce new meaning in the phenomena of political co-existence. Emergent, embodied, sensorial listening produces new awareness and understandings of intra-acting beings in an urban space regardless of age or form.

Social implications
Application of ethical ontological epistemological practice through emergent, embodied, sensorial listening to others opens affectual ethical ways of being and knowing for justice-to-come in political co-existence.

Originality/value
The concept of child-led walks is innovative as a political act by shifting from vertical adult-child relations to horizontal relations. Post-humanist agential realism is a new and emerging theory that offers possibilities to reconceptualise co-existence with others in public spaces.
Gender stereotypes in ecological research themes: An analysis of the last 20 years of the Argentinian ecology conferences
Authors: Spirito Florencia , Meli Paula , Reyes M. Fernanda , Núñez‐Vivanco Gabriel , Beloff Zoe , De Paepe Josefina L. 
Published: March 2023

AbstractAlthough Argentina harbours a notable increase in the academic community, achieving the highest number of researchers per capita in Latin America, the gender gap is still evident. The objective was to identify and evaluate the evolution of the main research themes in Argentinian ecology during the last 20 years to address whether social gender stereotypes were reproduced in research theme selection. We analysed four books of abstracts from the Argentinian Ecology conferences of the last 20 years and identified gender of the first author and co‐authors. Natural Language Processing approach was used to analyse gender associations with the 16 319 words appearing in the 2208 titles of abstracts. The average number of female co‐authors was always larger in female‐led abstracts although the proportion of female co‐authors/total authors increased the most in male‐led abstracts. Research themes evolved from those considered cornerstones of ecology (e.g. population‐oriented studies) to contemporary themes defined by Management and policy studies. Gender differences were present and changed with time. Currently, men work on research themes related to decision‐making, while women focus on environmental processes therefore it is urgent to create more leadership spaces for women to reduce gender inequalities.
Developmental regulators moonlighting as transposons defense factors
Authors: Tan Kun , Wilkinson Miles F. 
Published: March 2023

AbstractBackgroundThe germline perpetuates genetic information across generations. To maintain the integrity of the germline, transposable elements in the genome must be silenced, as these mobile elements would otherwise engender widespread mutations passed on to subsequent generations. There are several well‐established mechanisms that are dedicated to providing defense against transposable elements, including DNA methylation, RNA interference, and the PIWI‐interacting RNA pathway.ObjectivesRecently, several studies have provided evidence that transposon defense is not only provided by factors dedicated to this purpose but also factors with other roles, including in germline development. Many of these are transcription factors. Our objective is to summarize what is known about these “bi‐functional” transcriptional regulators.Materials and methodsLiterature search.Results and conclusionWe summarize the evidence that six transcriptional regulators—GLIS3, MYBL1, RB1, RHOX10, SETDB1, and ZBTB16—are both developmental regulators and transposable element‐defense factors. These factors act at different stages of germ cell development, including in pro‐spermatogonia, spermatogonial stem cells, and spermatocytes. Collectively, the data suggest a model in which specific key transcriptional regulators have acquired multiple functions over evolutionary time to influence developmental decisions and safeguard transgenerational genetic information. It remains to be determined whether their developmental roles were primordial and their transposon defense roles were co‐opted, or vice versa.
Reliability of the Motor Optimality Score‐Revised: A study of infants at elevated likelihood for adverse neurological outcomes
Authors: Örtqvist Maria , Marschik Peter B. , Toldo Moreno , Zhang Dajie , Fajardo‐Martinez Viviana , Nielsen‐Saines Karin , Ådén Ulrika , Einspieler Christa 
Published: March 2023

AbstractAimTo assess the inter‐assessor reliability of the Motor Optimality Score‐Revised (MOS‐R) when used in infants at elevated likelihood for adverse neurological outcome.MethodsMOS‐R were assessed in three groups of infants by two assessors/cohort. Infants were recruited from longitudinal projects in Sweden (infants born extremely preterm), India (infants born in low‐resource communities) and the USA (infants prenatally exposed to SARS‐CoV‐2). Intraclass correlation coefficients (ICC) and kappa (κw) were applied. ICC of MOS‐R subcategories and total scores were presented for cohorts together and separately and for age‐spans: 9–12, 13–16 and 17–25‐weeks post‐term age.Results252 infants were included (born extremely preterm n = 97, born in low‐resource communities n = 97, prenatally SARS‐CoV‐2 exposed n = 58). Reliability of the total MOS‐R was almost perfect (ICC: 0.98–0.99) for all cohorts, together and separately. Similar result was found for age‐spans (ICC: 0.98–0.99). Substantial to perfect reliability was shown for the MOS‐R subcategories (κw: 0.67–1.00), with postural patterns showing the lowest value 0.67.ConclusionThe MOS‐R can be used in high‐risk populations with substantial to perfect reliability, both in regards of total/subcategory scores as well as in different age groups. However, the subcategory postural patterns as well as the clinical applicability of the MOS‐R needs further study.
Growth hormone treatment and the risk of adolescent scoliosis: A large matched cohort study
Authors: Ziv‐Baran Tomer , Modan‐Moses Dalit , Zacay Galia , Ackshota Nissim , Levy‐Shraga Yael 
Published: March 2023

AbstractAimWe aimed to evaluate the risk of developing adolescent scoliosis among recipients of recombinant human growth hormone (rhGH).MethodsThis registry‐based cohort study included 1314 individuals who initiated rhGH treatment since 2013, treated during 10–18 years of age for at least 6 months. This group was matched to a comparison group of 6570 individuals not treated with rhGH. Demographic and clinical information was extracted from the electronic database. The results are presented using hazard ratios (HR) and 95% confidence intervals (CI).ResultsDuring a median follow‐up of 4.2 years, 59 (4.5%) rhGH recipients and 141 individuals (2.1%) from the comparison group were diagnosed with adolescent scoliosis. The age at diagnosis did not differ between the groups (14.7 versus 14.3 years, p = 0.095). Patients treated with rhGH were more likely diagnosed with scoliosis (HR 2.12, 95% CI 1.55–2.88, p < 0.001). Among males, the risk was about three times greater in the treated versus the comparison group (HR 3.15, 95% CI 2.12–4.68, p < 0.001), while in females the risk was not increased (HR 1.12, 95% CI 0.72–2.04, p = 0.469).ConclusionsRecombinant human growth hormone treatment was associated with an increased risk to be diagnosed with adolescent scoliosis in males. Scoliosis development should be monitored appropriately in rhGH recipients.
The ARchaeological Organic residues Literature Database (AROLD): Construction of a tool for reviewing and querying published lipid data in organic residue analysis
Authors: Prévost Camielsa , Drieu Léa , Pasqualini Antoine , Regert Martine 
Published: March 2023

AbstractThe first attempts to identify amorphous organic substances in archaeology date to the end of the 19th century and the beginning of the 20th century. The 1960s saw the development of infrared spectrometry, and then separative and mass spectrometry analyses were implemented in the 1980s. But it is only since the 1990s that extended and systematic research programmes were devoted to these substances. The number of publications has not stopped growing and is becoming exponential. To get an overview of the lipid studies in archaeology, we conceived the ARchaeological Organic residues Literature Database (AROLD) as a first structured and collaborative research tool. This paper describes the challenges of setting up such a database, details its architecture, presents the choices involved in its implementation, and discusses the possibilities of sharing and evolving this tool.
Interim Monitoring of Sequential Multiple Assignment Randomized Trials Using Partial Information
Authors: Manschot Cole , Laber Eric , Davidian Marie 
Published: March 2023

Abstract
The sequential multiple assignment randomized trial (SMART) is the gold standard trial design to generate data for the evaluation of multistage treatment regimes. As with conventional (single-stage) randomized clinical trials, interim monitoring allows early stopping; however, there are few methods for principled interim analysis in SMARTs. Because SMARTs involve multiple stages of treatment, a key challenge is that not all enrolled participants will have progressed through all treatment stages at the time of an interim analysis. Wu et al. (2021) propose basing interim analyses on an estimator for the mean outcome under a given regime that uses data only from participants who have completed all treatment stages. We propose an estimator for the mean outcome under a given regime that gains efficiency by using partial information from enrolled participants regardless of their progression through treatment stages. Using the asymptotic distribution of this estimator, we derive associated Pocock and O'Brien-Fleming testing procedures for early stopping. In simulation experiments, the estimator controls type I error and achieves nominal power while reducing expected sample size relative to the method of Wu et al. (2021). We present an illustrative application of the proposed estimator based on a recent SMART evaluating behavioral pain interventions for breast cancer patients.
Emotion dysregulation and symptoms of anxiety and depression in early adolescence: Bidirectional longitudinal associations and the antecedent role of parent–child attachment
Authors: Chan Kelly M. Y. , Hong Ryan Y. , Ong Xiang Ling , Cheung Hoi Shan 
Published: March 2023

AbstractDifficulties in emotion regulation have been consistently associated with various psychological difficulties, including anxiety and depression; however, less is known about the directionality of this relationship, particularly in adolescents. In addition, early parent–child attachment quality has been closely linked to the development of emotion regulation. Previous studies have proposed an overarching model in attempt to describe the developmental trajectory of anxiety and depression from early attachment, albeit with several limitations that are discussed in this paper. This study adds to this field of research by investigating the longitudinal associations between emotion dysregulation (ED) and symptoms of anxiety and depression among 534 early adolescents in Singapore over three timepoints in a school year, and the antecedent role of attachment quality on individual differences on these variables. Bidirectional influences were found between ED and anxiety and depression symptoms, respectively, between T1 and T2, but not T2 and T3, at the between‐ and within‐individual levels of analysis. Additionally, attachment anxiety and avoidance were both significantly predictive of individual differences in ED and for both psychological symptoms. The current findings provide preliminary evidence of a mutually reinforcing relationship between ED and symptoms of anxiety and depression in early adolescence, where attachment quality serves as a developmental antecedent that sets these longitudinal associations in motion.
First report of outcomes in patients with stage IIIb AL amyloidosis treated with Dara–VCD front‐line therapy
Authors: Chakraborty Rajshekhar , Rosenbaum Cara , Kaur Gurbakhash , Bhutani Divaya , Radhakrishnan Jai , Mapara Markus Y. , Maurer Mathew , Lentzsch Suzanne 
Published: March 2023

SummaryAlthough Dara–VCD (daratumumab–bortezomib–cyclophosphamide–dexamethasone) has revolutionized the treatment of newly diagnosed Amyloid Light chain (AL) amyloidosis, patients with stage IIIb disease were excluded in the pivotal trial. We performed a multicentre retrospective cohort study to investigate the outcomes of 19 consecutive patients treated with Dara–VCD front‐line therapy who had stage IIIb AL at diagnosis. More than two thirds presented with New York Heart Association Class III/IV symptoms, and had a median of two organs involved (range, 2–4). The haematologic overall response rate was 100%, with 17/19 patients (89.5%) achieving a very good partial response (VGPR) or better. Haematologic responses were achieved rapidly, as evidenced by 63% of evaluable patients with involved serum free light chains (iFLC) < 2 mg/dl and the difference between involved and uninvolved serum free light chains (dFLC) <1 mg/dl at three months. Among 18 evaluable patients, 10 (56%) achieved a cardiac organ response and six (33%) cardiac VGPR or better. The median time to first cardiac response was 1.9 months (range, 0.4–7.3). At a median follow‐up of 12 months for surviving patients, estimated one‐year overall survival was 67.5% [95% confidence interval (CI), 43.8–84.7]. The incidence of grade 3 or higher infections was 21%, with no infection‐related mortality thus far. In summary, Dara–VCD has a promising efficacy and safety profile in stage IIIb AL, and should be studied in prospective trials.
The influence of fiscal policy uncertainty on corporate total factor productivity: Evidence from Chinese public companies
Authors: Zhang Rongwu , Luo Lan , Du Jianjun 
Published: March 2023

AbstractThis paper uses China's public companies to test the influence of fiscal policy uncertainty on corporate total factor productivity. The study finds that fiscal policy uncertainty has a negative impact on the total factor productivity, and the effect of conservative tax avoidance, a mediating variable between the two, is found more significant for non‐state‐owned and non‐recession‐stage enterprises. The study further finds that facing fiscal policy uncertainty, companies reduce R&D investment, which will deteriorate productivity. The overall results show that if the government maintains relatively stable fiscal policies, it will positively improve corporate total factor productivity, even in a longer period.
Understanding spillover of peer parental education: Randomization evidence and mechanisms
Authors: Chung Bobby W. , Zou Jian 
Published: March 2023

AbstractThe educational background of peer parents is more than a proxy for peer quality. We utilize random classroom assignments in China middle schools to study the spillover of peer parental education on the student test score. Analyzing the China Education Panel Survey, we find a causal relationship between the average college attainment of classmates' mothers and a student's test score. Besides peer quality and teacher response, we identify the change in the mother's parenting style as a mediating factor. The parental responses (time, money, and parenting style) also differ by family background, leading to heterogeneous spillover on the test score.
Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?
Authors: Haigh Sarah M. , Berryhill Marian E. , Kilgore‐Gomez Alexandrea , Dodd Michael 
Published: March 2023

AbstractThe search for robust, reliable biomarkers of schizophrenia remains a high priority in psychiatry. Biomarkers are valuable because they can reveal the underlying mechanisms of symptoms and monitor treatment progress and may predict future risk of developing schizophrenia. Despite the existence of various promising biomarkers that relate to symptoms across the schizophrenia spectrum, and despite published recommendations encouraging multivariate metrics, they are rarely investigated simultaneously within the same individuals. In those with schizophrenia, the magnitude of purported biomarkers is complicated by comorbid diagnoses, medications and other treatments. Here, we argue three points. First, we reiterate the importance of assessing multiple biomarkers simultaneously. Second, we argue that investigating biomarkers in those with schizophrenia‐related traits (schizotypy) in the general population can accelerate progress in understanding the mechanisms of schizophrenia. We focus on biomarkers of sensory and working memory in schizophrenia and their smaller effects in individuals with nonclinical schizotypy. Third, we note irregularities across research domains leading to the current situation in which there is a preponderance of data on auditory sensory memory and visual working memory, but markedly less in visual (iconic) memory and auditory working memory, particularly when focusing on schizotypy where data are either scarce or inconsistent. Together, this review highlights opportunities for researchers without access to clinical populations to address gaps in knowledge. We conclude by highlighting the theory that early sensory memory deficits contribute negatively to working memory and vice versa. This presents a mechanistic perspective where biomarkers may interact with one another and impact schizophrenia‐related symptoms.
Mechanisms driving interspecific variation in regional synchrony of trees reproduction
Authors: Bogdziewicz Michał , Journé Valentin , Hacket‐Pain Andrew , Szymkowiak Jakub 
Published: March 2023

AbstractSeed production in many plants is characterized by large interannual variation, which is synchronized at subcontinental scales in some species but local in others. The reproductive synchrony affects animal migrations, trophic responses to resource pulses and the planning of management and conservation. Spatial synchrony of reproduction is typically attributed to the Moran effect, but this alone is unable to explain interspecific differences in synchrony. We show that interspecific differences in the conservation of seed production‐weather relationships combine with the Moran effect to explain variation in reproductive synchrony. Conservative timing of weather cues that trigger masting allows populations to be synchronized at distances >1000 km. Conversely, if populations respond to variable weather signals, synchrony cannot be achieved. Our study shows that species vary in the extent to which their weather cueing is spatiotemporally conserved, with important consequences, including an interspecific variation of masting vulnerability to climate change.
Effect of the revised definition of epilepsy on treatment decisions and seizure recurrence after a first epileptic seizure
Authors: Linka Louise , Magnus Benedikt , Habermehl Lena , Tsalouchidou Panagiota‐Eleni , Zahnert Felix , Möeller Leona , Krause Kristina , Knake Susanne , Menzler Katja 
Published: March 2023

AbstractBackgroundStudies on risk factors for epilepsy and seizure recurrence after a first seizure are usually based on the old definition of epilepsy with the need for two unprovoked seizures. The current definition of epilepsy allows diagnosis and treatment of epilepsy after a first seizure if the recurrence risk is >60%. We evaluate treatment decisions, seizure recurrence and risk factors for epilepsy related to the application of the new definition of epilepsy.MethodsData of 629 patients with a first seizure were analyzed to investigate changes of treatment decisions and seizure recurrence after the revised definition of epilepsy. We used binary logistic regression to investigate the impact of multiple factors influencing seizure recurrence like electroencephalogram (EEG) and magnetic resonance imaging (MRI) results and administration of antiseizure medication (ASM).ResultsThe proportion of patients receiving ASM significantly increased from 70.4% to 80.5% (p = 0.015) following the new epilepsy definition, without any significant changes in the recurrence rate (40.8% vs. 45.5% after 2 years, p > 0.05). The presence of interictal epileptiform discharges (IED) in the EEG increased (OR = 1.98) and administration of ASM decreased (OR = 0.43) recurrence rates significantly.ConclusionsThe new definition of epilepsy was associated with increased application of ASM, but not with reduced recurrence rates. The study confirms the presence of IED as a strong risk factor for seizure recurrence and the protective effect of ASM. The influence of imaging findings, which have a strong impact on the new definition of epilepsy, could not be confirmed.