bluuebunny/crossref_metadata_2025_split huggingface dataset:
MALIGNANT TUMORS IN PEDIATRIC POPULATION OF UKRAINE: TRENDS AND STRUCTURAL FEATURES
Authors: Shipko A.F. , Fedorenko Z.P. , Ryzhov A.Yu. 
Published: February 2023

The creation of a central bank of personalized information of cancer patients, including children, allowed to obtain objective data and establish continuous cancer surveillance in the child population in Ukraine. The aim of the study was to analyze the dynamics of cancer incidence (1989–2019) and mortality (1999–2019) based on the 3rd revision of International Classification of Childhood Cancer (ICCC-3). Materials and Methods: A study cohort includes 31,537 patients aged 0–19 years at the time of diagnosis in 1989–2019, registered in Ukrainian population. Results: The major groups of malignancies in the child population are presented by leukemia, lymphomas, central nervous system (CNS) tumors, epithelial neoplasms, bone cancer and soft tissues sarcomas. There were observed no gender differences in cancer incidence, except germ cell tumors and trophoblastic tumors, gonadal malignancies, as well as some other malignant epithelial neoplasms, with their proportion being twice higher in the female population. Our analysis showed a trend towards increase in the incidence of leukemia, CNS neoplasms, neuroblastoma, trophoblastic tumors and epithelial malignancies; decrease in the incidence of lymphomas and bone neoplasms; stabilization in the incidence of malignancies of liver and kidneys. The dynamic changes in cancer mortality in the studied cohort were observed, namely, the decrease of mortality from leukemias and lymphomas in males (but not in females), along with the increase of mortality from CNS neoplasms, neuroblastoma, soft tissues sarcomas and germ cell tumors, regardless of gender. Conclusions: The analysis and presentation of the epidemiological data on children’s malignancies implementing ICCC-3 classification for all relevant records in the National Cancer Registry of Ukraine allows for evaluating the major trends of cancer incidence and mortality in Ukrainian pediatric population, taking into account tumor morphology, topography, gender and age.
EXPRESSION PATTERN OF miR-125b-2, -155, -221, AND -320a IS ASSOCIATED WITH RESPONSE OF BREAST CANCER PATIENTS TO TAMOXIFEN
Authors: Pridko O. , Borikun T. , Rossylna O. , Rishko M. , Rusyn A.V. 
Published: February 2023

Background: Hormonal therapy is one of the main methods of comprehensive treatment of patients with locally advanced breast cancer (BC). Despite the intensive search for molecules associated with the aggressiveness of the tumor process, currently there are no reliable markers predicting response to neoadjuvant hormonal therapy (NHT). Aim: To investigate the correlation between miR-125b-2, -155, -221, -320a expression in tumor tissue and HER2/neu status and response to tamoxifen treatment in BC patients. Materials and Methods: Expression levels of miR-125b-2, -155, -221, and -320a were analyzed in biopsy samples of 50 BC patients using a real-time polymerase chain reaction. Results: We found that levels of miR-125b-2, -155, -221, and -320a were 1.72, 1.65, 1.85, and 2.89 times higher in BC biopsy samples expressing estrogen/progesterone receptors and HER2/neu compared with HER2/neu-negative luminal tumors. Patients with a luminal BC showing higher levels of miR-125b-2 and miR-320a expression before therapy demonstrated better response to NHT with tamoxifen. A strong correlation was calculated for miR-221 expression and response to NHT (r = 0.61). Conclusions: The high levels of miR-125b-2, -155, -221, and -320a in tumor tissue are associated with the HER2/neu-positive status of luminal BC subtypes. Tumor samples of patients showing the low response to NHT with tamoxifen are characterized by lower expression of miR-125b-2 and -320a. Hence, miR-125b-2 and -320a could be considered as putative predictive biomarkers associated with tamoxifen sensitivity of hormone-dependent BC.
Socio-cultural analysis on a textbook Grow with English for students of elementary schools
Authors: Wati Yuli Yana , Sugesti Ikariya 
Published: February 2023

Indonesian culture is often connected with the reality of life and it appears on textbook Grow with English. This research aims to analyze the representation of Indonesian culture on Grow with English textbook for third grade of elementary school. The problems of the research are the teacher only focuses on theory or language itself, without recognizing another aspect inside the textbook that is socio-cultural aspect. Students have difficultly to know Indonesian culture that appears on the English textbook. This research was descriptive qualitative by which the researcher interprets of Indonesian culture in the data of word and description from picture. The findings showed that there were various illustrations that indicated Indonesian culture, the characters’ name indicated of origin, traditional attribute that indicated of religion, traditional home living, traditional food, traditional toys and game, the last about physical appearance of the character and it is indicated socio-cultural aspect. Furthermore, for teachers who are interested in doing similar research, this research will be reference, it is appropriate English textbook for elementary school and as contribution to comprehend that Indonesian culture appears on Grow with English textbook and recommended to use it continually.
Keywords: socio-cultural; textbook; students of elementary school
Writing development in K-Pop stan Twitter communities
Authors: Darmawan Dinda Alifia , Izzah Lidiyatul 
Published: February 2023

This research focuses on the use of language in social interactions, specifically within the context of K-Pop fans using social media platform Twitter to communicate with other fanbases. The study aims to determine the impact of the K-Pop community on Twitter on the writing skills of high school students in English. The research method employed is quantitative, using a sample of 100 high school students who are members of the K-Pop community on Twitter for at least a year and have studied English. Data was collected using a Likert scale. Results of the analysis indicate a significant effect of the Twitter community on the development of student's writing skills in English
Keywords: Twitter; K-Pop; Writing
The Construction of turn taking and interactional moves pragmatics analysis in drama Tarling Cirebon
Authors: ZA Dede Rosyadi 
Published: February 2023

This study examines how turn construction talks and the conversational interaction movements that have been distributed by Cirebon Tarling drama actors that are in the form of conversation. Analysis of identity, motivation, and ideology complements this analysis to identify identity, motivation, and ideology which are the backgrounds for the turn construction of speech and the movement of conversation interactions. Data was obtained from two sources, namely first, the Cirebon Tarling drama entitled “Gila Harta Warisan” and “Mencari Wali Sejati”. The initial data is in the form of video. Then the researcher listens and looks at it and changes it into a conversation transcript. The method that used is descriptive method. Techniques used through transcription, recording, collection, reduction, and analyzing. The results of the study show the following: Identified turn taking construction and the construction of interactional moves in the Cirebon regional languages ??are not much different from English. It was identified that there were participants who started the conversation with small talk or older siblings. A person's identity plays an important role in acting speech. Identity influences the speech of the speaker. Motivation is the impulse of someone in acting well or acting in speech. In this study motivation becomes a person's background in speaking. Ideology is a person's principle in acting behavior and acting speech. The relation between the identity, motivation, and ideology of participants is very related.
keywords: turn taking; interactional moves; identity; motivation; ideology.
Augmenting scientific literacy through HOTS instruction in EFL classroom: Students’ perception
Authors: Wijaya Armeria 
Published: February 2023

This paper examines students' perceptions of the current practice of using Higher Order Thinking Skills (HOTS) in the classroom to enhance their scientific literacy. The study was prompted by the traditional monotonous teaching of Sociolinguistics. Pre-observation activities revealed that students found the traditional sequence of classroom movement tedious and impractical in linguistics learning. Using students' presentations and classroom discussions as a learning strategy, which are considered low-order thinking skills, resulted in students not being engaged in the discussion. However, after learning with HOTS instructions, it was found that activities such as analyzing sociolinguistics phenomena, evaluating them, and proposing ideas for further research in the field of sociolinguistics, brought new perspectives to the learning experience. The results of the questionnaires, analyzed qualitatively, showed that students had positive perceptions of learning with HOTS instructions; their scientific literacy was competently advanced, the scientific knowledge was advantageous for their social and academic interactions, and they were able to identify connections between sociolinguistics and technology. In conclusion, English as a Foreign Language (EFL) students' scientific literacy can be enhanced through this type of instruction
Keywords: Students’ Perception; Scientific Literacy; Augmenting Scientific Literacy; HOTS Instruction; EFL Classroom
Students’ digital literacy analysis in Institut Pendidikan Tapanuli Selatan based on length of study and gender
Authors: Hasibuan Asriani , Hasibuan Derliana 
Published: February 2023

The aim of this research is to analyze the digital literacy abilities of students at the South Tapanuli Institute of Education in terms of the length of study and gender. This research is quantitative and descriptive. Based on the research results, it can be concluded that students with different lengths of study and gender have different abilities to use technology. The achievement percentage for functional skills and beyond is 85% and 87% respectively, with males achieving 75% and females achieving 78%. The ability to find and select information is in the "very good" category with an achievement percentage of 85% and 87%. For critical thinking and evaluation, students in semester 5 achieved 65%, while students in semester 7 achieved 72%. Males achieved 75% and females achieved 78%. For cultural and social understanding, students in semester 5 achieved 50%, while students in semester 7 achieved 50%. Males achieved 53% and females achieved 40%. For e-safety, students in semester 5 achieved 70%, while students in semester 7 achieved 73%. Males achieved 70% and females achieved 72%. The results of the study also show that the comparison of digital literacy abilities of students with different lengths of study, semester 7 is greater than semester 5. The value of digital literacy for females is 87% higher than the value for digital literacy for males, which is 85%.
Keywords: literacy digital; students; length of study; gender
Lesiones anogenitales por Virus Papiloma Humano. Estudio de prevalencia en niños, niñas y adolescentes no vacunados
Authors: Romero F. Patricia , Ramírez V. Eugenio , Muñoz O. Monica , Muñoz M. Paula , González L. Carolina , Orellana C. Carolina , Pastene S. Carolina , Balanda A. Montserrat , Vergara V. Nicolas , Reyes P. Alvaro 
Published: February 2023

La prevalencia de infección por virus Papiloma Humano (VPH) es desconocida en niños, niñas y adolescentes (NNA) chilenos. En 2014 se incorporó en Chile la vacuna VPH al Programa Nacional de Inmunizaciones en niñas y en varones el 2019. Objetivo: Determinar la prevalencia, genotipos y características de la infección por VPH en NNA con lesiones anogenitales no vacunados contra VPH. Pacientes y Método: Se estudiaron NNA con lesiones anogenitales que consultaron en el Hospital Calvo Mackenna entre 2013 y 2017. Se registró motivo de consulta, edad, sexo, antecedentes de familiar portador de lesiones por VPH, antecedente de vulneración sexual, y actividad sexual consentida. Se detectó VPH por PCR y tipificación mediante hibridación reversa en línea del gen L1. Las muestras se analizaron en la Sección de Virus Oncogénicos del Instituto de Salud Pública. Resultados: Se estudiaron 110 pacientes; 44.5% niños/as. Se detectó VPH en 34 (30,9% [IC95% 22,4- 40,4]); 22 (44,9%) niños/as y 12 (19,7%) adolescentes. Once (91,7%) adolescentes tenían antecedente de contacto sexual (p < 0,005); 4 (18,2%) niños/as develaron vulneración sexual. 25% de las lesiones genitales y 50% de las perianales eran VPH (+) (p 0,015). Los genotipos más frecuentes fueron 59, 58, 16, 18, 6 y 11. En niños/as se detectó sólo genotipos de bajo riesgo. En 91.7% de las adolescentes VPH (+) se detectaron genotipos de alto riesgo. Conclusión: La prevalencia de infección por VPH fue 30%. En adolescentes la infección estuvo relacionada a contacto sexual y a VPH de alto riesgo. En niños/as se asoció a genotipos de bajo riesgo. Las lesiones perianales se asociaron con mayor frecuencia que las genitales a infección por VPH. La inspección visual no permite precisar la etiología de las lesiones genitales, por lo que es necesario realizar test de PCR para virus papiloma humano.
Lactancia materna exclusiva y evolución de la enfermedad en lactantes hospitalizados por bronquiolitis
Authors: Giunchetti Felicitas , Hidalgo Leila E. , Penas Marisol , Piccardo Agustina , Rodriguez Laura S. , Ferrero Fernando , Ibarra Mariano 
Published: February 2023

La bronquiolitis es el principal motivo de hospitalización en la infancia. La lactancia materna es un factor protector frente a infecciones. Aunque hay evidencia de que la lactancia materna podría prevenir las hospitalizaciones por bronquiolitis, menos claro es su efecto en los pacientes ya hospitalizados por esta enfermedad. Objetivo: Evaluar si existen diferencias en la evolución de pacientes hospitalizados por bronquiolitis alimentados con leche materna exclusiva (LME) vs. sucedáneos de leche materna (SuLM). Pacientes y Método: Estudio de cohorte prospectivo. Se incluyeron niños hospitalizados por bronquiolitis de 1 a 6 meses de edad. Se comparó la evolución respecto a días de hospitalización, días de oxigenoterapia, requerimiento de cánula de alto flujo de oxígeno (CAFO), presencia de neumonía asociada, traslado a terapia intensiva y muerte. Resultados: En el período de estudio 131 lactantes hospitalizados por bronquiolitis cumplieron los criterios de selección: 54 alimentados con LME, 29 con SuLM y 48 recibieron alimentación mixta. El grupo LME requirió significativamente menos días de oxigenoterapia (5,1 ± 2,4 vs. 6,6 ± 3,5; p < 0,02) y hospitalización (7,0 ± 2,4 vs. 8,4 ± 3,6; p < 0,04) que el grupo SuLM. Si bien los varones del grupo SuLM requirieron en promedio más días de hospitalización y oxigenoterapia, esta diferencia no fue estadísticamente significativa. No se registraron fallecimientos en los grupos estudiados. Conclusión: Los pacientes alimentados con LME requirieron menos días de oxigenoterapia y de hospitalización que los que recibieron SuLM.
Prevalencia, riesgo de progresión y calidad de vida en estudiantes tamizados para escoliosis idiopática adolescente
Authors: Cárcamo Marcela , Espinoza Pamela , Rodas Macarena , Urrejola Óscar , Bettany-Saltikov Josette , Grivas Theodoros B 
Published: February 2023

Objetivo: Determinar la prevalencia de Escoliosis Idiopática del Adolescente (EIA), riesgo de progre- sión (RP) y Calidad de vida (CdV) en estudiantes entre 10 a 18 años. Pacientes y Método: Estudio descriptivo transversal. Se incluyeron estudiantes de 10 a 18 años de cinco comunas de Región Metropolitana (RM), Chile. Se realizó Prueba de Adams y con escoliómetro se midió el ángulo de rotación del tronco (ART) a nivel de columna torácica, toracolumbar y lumbar. Si ART era ≥ 6°, se realizó exploración radiológica de columna completa anteroposterior y lateral, midiendo posteriormente ángulo de Cobb. Se confirmó escoliosis con ángulo de Cobb ≥ 10° con rotación vertebral. Se calculó factor de progresión mediante fórmula de Lonstein & Carlston. Para evaluar la CdV se utilizaron los cuestionarios de CdV en deformidades del raquis y escala de percepción de apariencia del tronco. Resultados: 1200 estudiantes fueron examinados. 54,92% mujeres. 8,17% tenía ART ≥ 6°. Se encontró escoliosis leve en 2,91%; moderada en 0,75% y severa en 0,17%. La prevalencia total fue 3,83% (IC 95%: 2,74 - 4,92). El 82,61% de los casos de EIA pesquisados correspondieron a diagnóstico tardío, cuando los estudiantes habían superado el estirón del crecimiento. De los casos de escoliosis, 21,74% tenían RP ≥ 50%. La CdV se correlacionó positivamente con gravedad de la curva, sin diferencias estadísticamente significativas. Conclusiones: Prevalencia de EIA fue 3,83%. La mayoría de las EIA fueron pesquisados cuando los estudiantes habían superado el estirón del crecimiento, con alto riesgo de progresión. La CdV de vida se correlacionó positiva y débilmente con gravedad de la curva.
Trastorno de sueño inquieto: una nueva entidad clínica a considerar en niños
Authors: Rojas Henríquez Mariela , Hernández Gómez Alejandra , Balut Oyarzun Fernanda , Pereira Hernández Valentina , Jiménez Perfetti Ana 
Published: February 2023

El Trastorno de Sueño Inquieto (sigla en inglés RSD: Restless Sleep Disorder) es un cuadro recientemente descrito por un grupo de expertos en sueño que elaboró criterios diagnósticos y polisomnográficos después de realizar una acuciosa revisión de la bibliografía disponible donde se mencionaba un mal dormir o sueño inquieto como síntoma único o acompañante de otros trastornos. Este grupo definió el TSI como un cuadro caracterizado por la queja parental de movimientos gruesos frecuentes durante el sueño, de reposicionamiento y disrupción del sueño que causan deterioro significativo diurno. Los criterios diagnósticos incluyen presencia de síntomas durante 3 meses, al menos 3 veces por semana, y hallazgos polisomnográficos de al menos 5 movimientos/hora. Debe considerar cambios conductuales durante el día tales como somnolencia, irritabilidad e hiperactividad, y que estos no sean explicados por una condición médica, farmacológica o conductual secundaria. Su prevalencia está estimada en un 7,7 % de niños referidos por problemas de sueño. Los niños presentan usualmente niveles de ferritina bajo 50 ng/ml, un punto en común con el Síndrome de piernas inquietas. El tratamiento propuesto por expertos consiste en la suplementación de fierro, que ha demostrado beneficios en este grupo de pacientes. Para el diagnóstico debe descartarse cuadros secundarios de origen médico general u otros trastornos de sueño tales como Síndrome de piernas inquietas o Movimiento periódico de extremidades. El objetivo de esta revisión es revisar las recomendaciones actuales en esta entidad, describir las claves clínicas, fisiopatológicas y polisomnográficas, destacando la necesidad de dar a conocer este cuadro para ampliar los estudios en grupos etarios diferentes a los ya definidos y generar pautas de tratamiento.
HUBUNGAN LAMA SAKIT DENGAN MANIFESTASI KLINIS PADA PASIEN CUTANEOUS LUPUS ERYTHEMATOSUS DI KOMUNITAS LAMPUNG TAHUN 2019
Authors: Nugraheni Vini , Panonsih Resati Nando , Purwaningrum Ratna , Prasetia Toni 
Published: February 2023

<p><em>Cutaneous Lupus Erythematosus (CLE) is a chronic disease of the skin that may require a long-term care and follow-up. Erythema, burning, scaling, itching, scarring, dyspigmentation, as well as the pain and the length of one of these diseases can be divided into acute and chronic.To the purpose of this research was to determine the correlatiom between long sick with clinical manifestasions in Cutaneous Lupus Erythematosus (CLE) patients in Lampung year 2020. This type of research is peneltian observational analytic with cross sectional approach. Samples of this research that people with lupus in Lampung as many as 45 people. Data were obtained through a questionnaire to fill a long illness and a physical examination. Data analysis techniques to test the hypothesis that the Chi-square test. The research showed a correlation between long sick with clinical manifestasions in Cutaneous Lupus Erythematosus (CLE) in Lampung Year 2019. Given between long sick with clinical manifestasions in Cutaneous Lupus Erythematosus (CLE) that the statistical test results obtained with p-value 0.000 (less than ɑ 0,05) which means Ha accepted. </em></p><p><strong><em> </em></strong></p>
YOLK SAC TUMOR TESTIS SUATU LAPORAN KASUS
Authors: Oktora Meta Zulyati 
Published: February 2023

<p>Tumor yolk sac merupakan keganasan pada testis yang berasal dari sel germinal dan paling sering terjadi. Angka kejadiannya mencapai 90-95% dari seluruh keganasan pada testis. Tumor yolk sac tipe murni sering ditemukan pada usia muda. Diagnosis tumor yolk sac secara mikroskopis sering meragukan karena gambaran histopatologinya bermacam-macam. Ada sekitar 10 macam variasi pola histopatologis yang bisa muncul, baik dalam bentuk tumor yolk sac murni maupun campuran dengan tumor sel germinal yang lain. Artikel ini merupakan suatu laporan kasus pasien laki-laki usia 31 tahun yang datang dengan keluhan benjolan yang bertambah besar pada testis kanan. Pasien didiagnosis secara klinis menderita tumor testis dan dilakukam orkidektomi oleh dokter bedah urologi. Kemudian jaringan operasi dikirim ke laboratorium patologi anatomi dan didiagnosis sebagai suatu tumor yolk sac tipe murni pada testis dewasa. Secara mikroskopik tampak potongan jaringan (testis) dengan stroma mengandung proliferasi sel – sel dengan inti besar, pleomorfik, vesikular, kromatin kasar, nukleoli nyata, mitosis atipik dapat ditemukan. Sel – sel ini ada yang tersusun papiler, retikular, ada yang berbentuk struktur kelenjar dan ada bagian yang padat (solid). Ditemukan adanya hyaline globule dan Schiller- Duval Body. Tampak pula bagian dengan nekrosis luas. Stadium pada pasien ini juga belum dapat ditegakkan, karena belum diperiksanya AFP.</p>
INJEKSI INTRAVITREAL RANIBIZUMAB PADA POLYPOIDAL CHOROIDAL VASCULOPATHY (PCV)
Authors: Budiman Haris , Helvinda Weni 
Published: February 2023

<p><strong><em>Introduction: </em></strong><em>Polypoidal choroidal vasculopathy (PCV) is a peculiar form of choroidal neovascularization characterized by protrusion of the aneurysm at the end of the choroidal blood vessels. The aim of this study is to report a case of PCV in a young woman who treated with intravitreal ranibizumab injection. <strong>Method: </strong>The patient undergoes general ophthalmic examinations, amsler grid, funduscopic photography and OCT analysis. The repeated examination performed after intravitreal injection of ranibizumab to assess the effect of therapy.</em> <strong><em>Result: </em></strong><em>Two weeks after intravitreal ranibizumab injection, the visual acuity was improved and on OCT examination revealed decreasing in macular thickness. <strong>Conclusion:</strong> Intravitreal ranibizumab injection can give good result, but in this case the effectiveness hasn’t so evident because of the administration only once and follow-up only in two weeks.</em></p>