bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of liraglutide on cardiometabolic profile and on bioelectrical impedance analysis in patients with obesity and metabolic syndrome
Authors: Freitas Frederico Perboyre Carioca , Rodrigues Carlos Ewerton Maia 
Published: August 2023

AbstractMetabolic syndrome (MetS) and obesity represent a public health problem worldwide. Bioelectrical impedance analysis (BIA) is a practical and effective way of evaluating body composition, especially abdominal fat. Liraglutide, a GLP-1 analog, reduces body weight and improves cardiometabolic parameters. In this prospective non-randomized intervention study, we evaluated the effect of 6 months of treatment with liraglutide (n = 57) on the clinical, laboratory and BIA findings of adult sex-stratified patients diagnosed with obesity and MetS, compared to a control group receiving sibutramine (n = 46). The groups were statistically similar with regard to the age of females (p = 0.852) and males (p = 0.657). Almost all anthropometric and BIA variables were higher in the treatment group than in the comparative group (p < 0.05). Abdominal circumference (AC) decreased significantly more in the treatment group. In males, body weight and fat mass also decreased (p < 0.05). Liraglutide treatment was associated with a greater reduction in trunk fat mass (FMT) (p < 0.05). AC and FMT were strongly correlated (rho = 0.531, p < 0.001) in the treatment group. In the multiple regression analysis, liraglutide treatment remained independently associated with FMT. Treatment with liraglutide for 6 months promoted weight loss, improved cardiometabolic and inflammatory parameters and led to a significant reduction in FMT correlated with AC in obese MetS patients of both sexes.
Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity
Authors: Tamura Suguru , Ishiguro Hajime , Suwabe Tatsuya , Katagiri Takayuki , Cho Kaori , Fuse Kyoko , Shibasaki Yasuhiko , Mikami Tadahisa , Shindo Takero , Kitagawa Hiroshi , Igarashi Michihiro , Sone Hirohito , Masuko Masayoshi , Ushiki Takashi 
Published: August 2023

AbstractDonor T cell activation, proliferation, differentiation, and migration are the major steps involved in graft-versus-host disease (GVHD) development following bone marrow transplantation. Chondroitin sulfate (CS) proteoglycan is a major component of the extracellular matrix and causes immune modulation by interacting with cell growth factors and inducing cell adhesion. However, its precise effects on immune function are unclear than those of other proteoglycan families. Thus, we investigated the significance of CS within donor cells in acute GVHD development utilizing CSGalNAc T1-knockout (T1KO) mice. To determine the effects of T1KO, the mice underwent allogenic bone marrow transplantation from major histocompatibility complex-mismatched donors. While transplantation resulted in hepatic GVHD with inflammatory cell infiltration of both CD4+ and CD8+ effector memory T cells, transplantation in T1KO-donors showed milder cell infiltration and improved survival with fewer splenic effector T cells. In vitro T-cell analyses showed that the ratio of effector memory T cells was significantly lower via phorbol myristate acetate/ionomycin stimulation. Moreover, quantitative PCR analyses showed significantly less production of inflammatory cytokines, such as IFN-γ and CCL-2, in splenocytes of T1KO mice. These results suggest that reduction of CS in donor blood cells may suppress the severity of acute GVHD after hematopoietic stem cell transplantation.
Comprehensive examination of tattoo removal using a 150 ps Nd:YAG laser in a porcine model
Authors: Baleisis Justinas , Rudys Romualdas 
Published: August 2023

AbstractThis study aimed to investigate the efficacy of a Nd:YAG laser with a pulse duration of 150 ps at different laser parameters. The effects on multiple-colored tattoos with such ultrashort pulses has not been previously described in the literature. In vivo experiments were conducted on porcine skin to analyze the fragmentation efficiency of five different tattoo colors using different wavelengths, pulse energies, and spot sizes. The results showed that the optimal tattoo clearance to safety ratio for blue, green, red, and yellow tattoos with a 532 nm wavelength was 0.96–2.39 J/cm2. The laser with a wavelength of 1064 nm demonstrated the highest efficacy in eliminating black tattoos, with positive results observed for green and blue pigments at a fluence of 3.02 J/cm2. The study provides valuable insights into the efficacy of laser treatment with 150 ps for removing tattoos of different colors using different laser parameters. This information can help dermatologists and practitioners perform more efficient and effective tattoo removal with fewer side effects.
Comparison of COVID-19 epidemic among Czech dentists and the Czech general population
Authors: Schmidt Jan , Perina Vojtech , Suchanek Jakub , Treglerova Jana , Pilbauerova Nela , Sanca Ondrej , Muzik Jan , Smucler Roman 
Published: August 2023

AbstractDentists are one of the professional groups most at risk for COVID-19 infection. Enhanced protective measures in dentistry have been adopted worldwide; however, it is unclear to what extent they were sufficient. To assess whether the protective measures outweighed the high infection risk, we compared COVID-19-related data between Czech dentists and the general Czech population. The data was obtained through a survey study attended by 15.8% of Czech Dental Chamber members. Data of the general population were acquired from the Czech Ministry of Health database. By the end of May 2022, COVID-19 full vaccination and 1st booster dose rates among study participants were 85.8% and 70.1%, respectively, which is significantly higher (p < 0.0001) compared to the Czech general population aged over 24 years (74.9% and 49.4%, respectively). To the same date, PCR/Antigen test verified COVID-19 prevalence among participants was 41.7%, and 49.9% among the general population (p < 0.0001). Prevalence and reinfection rates among individuals who received the 1st booster were significantly lower than among individuals without the booster or full vaccination (p < 0.0001). Persons who received the booster showed a faster return to work, shorter and different types of complications. Willingness to future vaccination was positive among 79.7% of respondents. Mandatory vaccination for healthcare workers and the general population was supported by 62.0% and 49.0%, respectively. The results showed that the high risk of COVID-19 infection associated with dentistry did not lead to higher COVID-19 prevalence among respondents compared to the general population.
Interannual impact of the Victoria mode on the winter-spring surface air temperature over Eurasia and North America
Authors: Ji Kai , Ding Ruiqiang 
Published: August 2023

AbstractVariations of the Victoria mode (VM) have received considerable attention due to their profound impacts on the climate systems in the pan-North Pacific. However, works about its impact on surface air temperature (SAT) variability over Eurasia and North America, which may be responsible for extreme weather and climate events, are limited. Here we show a significant positive and negative relationship between the VM and the winter-spring SAT anomalies over mid-to-high-latitude east-central Eurasia (MEE) and eastern North America (ENA), respectively. A local energy budget analysis shows that the contribution of the surface heat fluxes associated with the VM to the SAT anomalies is confined mainly to MEE and may not explain the formation of SAT anomalies over ENA. Furthermore, VM-induced anomalous atmospheric circulations play a crucial role in the formation of notable SAT anomalies. The positive (negative) VM is linked to negative (positive) precipitation and upper-tropospheric wind convergence (divergence) anomalies over the western North Pacific, which contribute to positive (negative) Rossby wave source (RWS) anomalies near the East Asian westerly jet core. These RWS anomalies act as disturbances that propagate eastward, exciting a wave train-like pattern. The high-level positive and negative geopotential height anomalies of the Rossby wave dominate MEE and ENA, respectively, leading to the variation in SAT anomalies. These results could advance our understanding of the relationship between the VM and SAT over the Northern Hemisphere and inspire us to pay more attention to the VM climate impacts.
Prevalence and clinico-genomic characteristics of patients with TRK fusion cancer in China
Authors: Xu Yujun , Shi Xiaoliang , Wang Weifeng , Zhang Lin , Cheung Shinghu , Rudolph Marion , Brega Nicoletta , Dong Xiaowei , Qian Lili , Wang Liwei , Yuan Shaohua , Tan Daniel Shao Weng , Wang Kai 
Published: August 2023

AbstractNeurotrophic tyrosine kinase (NTRK) fusions involving NTRK1, NTRK2, and NTRK3 were found in a broad range of solid tumors as driver gene variants. However, the prevalence of NTRK fusions in Chinese solid tumor patients is rarely reported. Based on the next-generation sequencing data from 10,194 Chinese solid tumor patients, we identified approximately 0.4% (40/10,194) of Chinese solid tumor patients with NTRK fusion. NTRK fusions were most frequently detected in soft tissue sarcoma (3.0%), especially in the fibrosarcoma subtype (12.7%). A total of 29 NTRK fusion patterns were identified, of which 11 were rarely reported. NTRK fusion mostly co-occurred with TP53 (38%), CDKN2A (23%), and ACVR2A (18%) and rarely with NTRK amplification (5.0%) and single nucleotide variants (2.5%). DNA-based NTRK fusion sequencing exhibited a higher detection rate than pan-TRK immunohistochemistry (100% vs. 87.5%). Two patients with NTRK fusions showed clinical responses to larotrectinib, supporting the effective response of NTRK fusion patients to TRK inhibitors.
Potential pathogenic germline variant reporting from tumor comprehensive genomic profiling complements classic approaches to germline testing
Authors: Tung Nadine , Dougherty Kali Chatham , Gatof Emily Stern , DeLeonardis Kim , Hogan Lauren , Tukachinsky Hanna , Gornstein Erica , Oxnard Geoffrey R. , McGregor Kimberly , Keller Rachel B. 
Published: August 2023

AbstractExisting guidance regarding clinically informed germline testing for patients with cancer is effective for evaluation of classic hereditary cancer syndromes and established gene/cancer type associations. However, current screening methods may miss patients with rare, reduced penetrance, or otherwise occult hereditary risk. Secondary finding of suspected germline variants that may confer inherited cancer risk via tumor comprehensive genomic profiling (CGP) has the potential to help address these limitations. However, reporting practices for secondary finding of germline variants are inconsistent, necessitating solutions for transparent and coherent communication of these potentially important findings. A workflow for improved confidence detection and clear reporting of potential pathogenic germline variants (PPGV) in select cancer susceptibility genes (CSG) was applied to a research dataset from real-world clinical tumor CGP of > 125,000 patients with advanced cancer. The presence and patterns of PPGVs identified across tumor types was assessed with a focus on scenarios in which traditional clinical germline evaluation may have been insufficient to capture genetic risk. PPGVs were identified in 9.7% of tumor CGP cases using tissue- and liquid-based assays across a broad range of cancer types, including in a number of “off-tumor” contexts. Overall, PPGVs were identified in a similar proportion of cancers with National Comprehensive Cancer Network (NCCN) recommendations for germline testing regardless of family history (11%) as in all other cancer types (9%). These findings suggest that tumor CGP can serve as a tool that is complementary to traditional germline genetic evaluation in helping to ascertain inherited susceptibility in patients with advanced cancer.
microRNA165 and 166 modulate response of the Arabidopsis root apical meristem to salt stress
Authors: Scintu Daria , Scacchi Emanuele , Cazzaniga Francesca , Vinciarelli Federico , De Vivo Mirko , Shtin Margaryta , Svolacchia Noemi , Bertolotti Gaia , Unterholzner Simon Josef , Del Bianco Marta , Timmermans Marja , Di Mambro Riccardo , Vittorioso Paola , Sabatini Sabrina , Costantino Paolo , Dello Ioio Raffaele 
Published: August 2023

AbstractIn plants, developmental plasticity allows for the modulation of organ growth in response to environmental cues. Being in contact with soil, roots are the first organ that responds to various types of soil abiotic stress such as high salt concentration. In the root, developmental plasticity relies on changes in the activity of the apical meristem, the region at the tip of the root where a set of self-renewing undifferentiated stem cells sustain growth. Here, we show that salt stress promotes differentiation of root meristem cells via reducing the dosage of the microRNAs miR165 and 166. By means of genetic, molecular and computational analysis, we show that the levels of miR165 and 166 respond to high salt concentration, and that miR165 and 166-dependent PHABULOSA (PHB) modulation is central to the response of root growth to this stress. Specifically, we show that salt-dependent reduction of miR165 and 166 causes a rapid increase in PHB expression and, hence, production of the root meristem pro-differentiation hormone cytokinin. Our data provide direct evidence for how the miRNA-dependent modulation of transcription factor dosage mediates plastic development in plants.
Early-onset gynecological tumors in DNA repair-deficient xeroderma pigmentosum group C patients: a case series
Authors: Yurchenko Andrey. A. , Fresneau Brice , Borghese Bruno , Rajabi Fatemeh , Tata Zora , Genestie Catherine , Sarasin Alain , Nikolaev Sergey I. 
Published: August 2023

Abstract
Background
Xeroderma pigmentosum (XP) is a group of rare hereditary disorders with highly increased risk of skin tumors due to defective DNA repair. Recently we reported 34-fold increased risk of internal tumors in XP patients in comparison with general population. The molecular data and clinical practice on the internal tumors treatment in XP patients is limited and scarcely represented in the medical literature. In this work, we describe young patients with constitutive biallelic deactivation of the XPC gene developing gynecological tumors with somatic DICER1 mutations.

Methods
Whole genome sequencing was used to analyze in detail somatic mutational landscape and driver events of these rare tumors.

Results
We describe five early-onset gynecological tumors in four xeroderma pigmentosum group C (XP-C) young patients (11 to 19 years old) including vaginal embryonal rhabdomyosarcomas in monozygotic twin sisters, juvenile granulosa-cell tumor of the ovary and poorly differentiated stage IA Sertoli-Leydig cell tumor in 19-years old patient, and FIGO stage IC1 tumor of ovary in 13-years old patient. XP-C ovarian tumors harbor 4.4 times more single base substitutions than sporadic tissue-matched cancers and demonstrate XP-C specific mutation signature with strong transcriptional bias indicating inability of the cells to repair bulky DNA lesions of unknown etiology. A special mode of treatment was applied to avoid usage of chemotherapy which is toxic for XP patients.

Conclusions
XP-C status should be accounted for prevention and specific treatment of gynecological tumors in young DNA repair-deficient XP patients.
Verbs Matter: A Tutorial for Determining Verb Difficulty
Authors: Finestack Lizbeth H. , Linert Jamie , Ancel Elizabeth , Hilliard Lisa , Munson Benjamin , Kuchler Kirstin , Matthys Olivia 
Published: August 2023

Purpose:
Research indicates that when teaching grammatical forms to children, the verbs used to model specific grammatical inflections matter. When learning grammatical forms, children have higher performance when they hear many unique verb forms that vary in their frequency and phonological complexity. In this tutorial, we demonstrate a method for identifying and characterizing a large number of verbs based on their frequency and complexity.

Method:

We selected verbs from an open-access database of transcribed child language samples. We extracted verbs produced by 5- to 8.9-year-old children in four morphosyntactic contexts: regular past tense
-ed
, third person singular
-s
,
is/are
+ verb+
ing
, and
do/does
questions. We ranked verbs based on their frequency of occurrence across transcripts. We also coded the phonological complexity of each verb. We coded each verb as high or low frequency and high or low phonological complexity.

Results:

The synthesis yielded 129 unique verbs used in the regular past tense
-ed
context, 107 verbs used in the third person singular -
s
context, 69 verbs used in the
is/are
+ verb+
ing
context, and 16 verbs used in the
do/does
question context. We created tables for each form that include the frequency rankings and phonological complexity scores for every verb.

Conclusions:
Clinicians may use the verb lists, frequency ratings, and phonological complexity scores to help identify verbs to incorporate into assessment and intervention sessions with children. Researchers and clinicians may use the step-by-step approach presented in the tutorial to identify verbs or other syntactic components used in different morphosyntactic contexts or produced by individuals of different demographics in different speaking contexts.
Stratifying Risk of Nonadherence in Lingual Strengthening Dysphagia Rehabilitation
Authors: Vitale Kailey , Powell W. Ryan , Krekeler Brittany N. , Yee Joanne , Rogus-Pulia Nicole 
Published: August 2023

Purpose:
Exercise-based treatments may improve swallowing safety and efficiency; yet, it is not clearly understood which factors predict nonadherence to recommended treatment protocols. The aim of this study was to construct an algorithm for stratifying risk of nonadherence to a lingual strengthening dysphagia treatment program.

Method:
Using recursive partitioning, we created a classification tree built from a pool of sociodemographic, clinical, and functional status indicators to identify risk groups for nonadherence to an intensive lingual strengthening treatment program. Nonadherence, or noncompletion, was defined as not completing two or more follow-up sessions or a final session within 84 days.

Results:
The study cohort consisted of 243 Veterans enrolled in the Intensive Dysphagia Treatment program across six sites from January 2012 to August 2019. The overall rate of nonadherence in this cohort was 38%. The classification tree demonstrated good discriminate validity (C-statistic = 0.74) and contained eight groups from five variables: primary diagnosis, marital status, Penetration–Aspiration Scale (PAS) severity score, race/ethnicity, and age. Nonadherence risk was categorized as high (range: 69%–77%), intermediate (27%–33%), and low risk (≤ 13%–22%).

Conclusions:
This study identified distinct risk groups for nonadherence to lingual strengthening dysphagia rehabilitation. Additional research is necessary to understand how these factors may drive nonadherence. With external validation and refinement through prospective studies, a clinically relevant risk stratification tool can be developed to identify patients who may be at high risk for nonadherence and provide targeted patient support to mitigate risk and provide for unmet needs.
Multi‐input fully CNN for joint pilot decontamination and symbol detection in 5G massive MIMO
Authors: Victor Crallet M. , Mvuma Alloys N. , Mrutu Salehe I. 
Published: August 2023

AbstractThis paper presents a multi‐input deep learning‐based joint pilot decontamination and symbol detection (SD) technique for 5G massive multiple‐input multiple‐output (MAMIMO) systems. It consists of a fully convolutional neural network (FCNN) that finds the 5G channel coefficients using pre‐known sounding reference signals (SRSs) under pilot contamination and a symbol detector derived from projected gradient descent iterations. The study considers pilot contamination caused by inter‐cell interferences between SRSs during channel estimation (CE). The proposed scheme accepts entire 5G orthogonal frequency modulated (OFDM) data and least square estimates and produces the transmitted OFDM signal. Simulation experiments demonstrated that the proposed technique has better CE and SD performance with reduced trainable parameters. Moreover, it is faster due to the lowest elapsed time during end‐to‐end OFDM symbol detection. This paper proposes a joint pilot decontamination and signal detection for 5G MAMIMO systems. It achieves better detection performance with the lowest number of trainable parameters and memory requirements. It is applicable in 5G OFDM symbol detection and channel estimation under pilot contamination.
An on‐orbit calibration method for time delay of inter‐satellite link transponder in tracking and data relay satellite
Authors: Wang Lei , Tong Kaixiang , Yang Jingyu , Chen Xiang 
Published: August 2023

AbstractThe tracking and data relay satellite (TDRS) in geosynchronous orbit (GEO) can provide ranging and communication services for user spacecraft in low Earth orbit (LEO) through the inter‐satellite link (ISL). The time delay of TDRS ISL transponder in orbit differs from its pre‐launch state and changes due to the complex space environment, adding significant errors to the user spacecraft's orbit determination based on four‐way ranging data. The authors have developed a calibration system and proposed an efficient on‐orbit calibration method for the ISL transponder's time delay in TDRS. Experimental results demonstrate the effectiveness of the authors’ method, and the RMS of calibration residuals is less than 0.5 m.
A four‐stage framework for optimal scheduling strategy of smart prosumers with vehicle‐to‐home capability under real time pricing based on interval optimization
Authors: Tostado‐Véliz Marcos , Ghadimi Ali Asghar , Miveh Mohammad Reza , Myyas Ra'ed Nahar , Jurado Francisco 
Published: August 2023

AbstractWith the emergence of the Smart Grid concept, utility companies require more active participation of home users in the power sector. This changing paradigm is enabled by the wide deployment of multiple home assets such as small renewable‐based generators or storage facilities. In this context, consumers are no longer conceived as pure loads but also active agents that can exchange energy with the grid. To promote this active participation, utility companies promote different price‐based demand response programs to change the consumer patterns on pursuing a more efficient and economic system operation. In this regard, home energy management programs are becoming an essential tool for efficiently managing the different home users while addressing multiple demand response goals at minimum cost. In essence, a home energy management system is a computational optimization tool, which has to handle multiple uncertainties brought by weather forecast or energy pricing. This paper tackles this issue by developing a novel robust home energy management program based on interval optimization. In contrast to other related approaches, the proposal avoids the explicit use of interval arithmetic. Instead, the different uncertain parameters are sequentially incorporated into the scheduling task through different stages and interval‐based formulation. The developed methodology incorporates weather, load, energy pricing and plug‐in electric vehicle related uncertainties. A benchmark case study in a smart prosumer layout serves to prove the effectiveness of the new approach.