bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between bi-spectral index and VOTE score in evaluation of drug-induced sleep endoscopy: A systematic meta-analysis
Authors: Öner Özlem , Ecevit Mustafa Cenk , Gökmen Ali Necati 
Published: September 2023

Objective:
The aim of this study was to investigate both the presence and severity of collapse in anatomical regions defined by the VOTE score (velum, orofarinx, tongue, and epiglottis), during drug induced sleep endoscopy (DISE) in patients diagnosed with obstructive sleep apnea, based on the bi-spectral index (BIS) sedation level.

Methods:
In order to conduct a meta-analysis of articles examining the relationship between the VOTE score and BIS sedation level in determining the presence and severity of upper airway collapse during DISE, a literature review was performed.

Results:
As a result of the search made in the specified databases, a total of 1864 articles were reached. Five articles included in this review that had sufficient statistical data to be included in the meta-analysis were found. A statistically significant correlation was found between the BIS sedation level and the areas of obstruction in the VOTE score. The strongest association is at the epiglottis level, followed by the velum, oropharynx, and tongue, respectively (CC: 0.639, CC: 0.53, CC: 0.49, and CC: 0.346, P < .001). In the subgroup analysis of publications with BIS sedation levels in the range of 60 to 65, the distribution in the epiglottis region was heterogeneous, and it was found to be statistically significant according to the random effect model (P < .001). The distribution in the tongue was homogeneous, and it was found to be statistically significant according to the fixed effect model (P < .001). When the publications in which the BIS sedation level is in the range of 65 to 75 are examined according to the areas of obstruction; the distribution in 4 anatomical regions was homogeneous and statistically significant according to the fixed effect model (P < .001).

Conclusion:
It was found that BIS sedation levels during DISE application in obstructive sleep apnea patients were associated with obstruction of the anatomical regions of the upper airway. The strongest association was found at the epiglottis level, followed by the velum, oropharynx, and tongue, respectively. It is helpful to monitor the sedation level with BIS in order to better define the collapsed areas during DISE application. However, more studies are needed to better understand the relationship between BIS sedation values and sleep stages.
A case report of dangerous pelvic infundibulum ligament in the second trimester of pregnancy with massive hemorrhage
Authors: Dai Jiahui , Chen Jin , Xu Xiaohan , Gao Ni , Wang Yunfei 
Published: September 2023

Rationale:
Abdominal pregnancy is a rare ectopic pregnancy and its diagnosis and treatment are more challenging than those of other ectopic pregnancies. Because of a variable pregnancy site, abdominal pregnancy is associated with an increased risk of fatal abdominal hemorrhage, and consequently, an increased risk of maternal death compared with intrauterine pregnancy.

Diagnoses:
Pelvic infundibulum ligament pregnancy complicated with massive hemorrhage.

Patient concerns:
42-year-old pregnant woman who did not undergo an obstetric examination during the first trimester presented with sudden abdominal pain during the second trimester. Abdominal pregnancy was confirmed after emergency treatment, causing difficulty in the comprehensive preoperative evaluation.
Interventions: In order to save the patient life, we actively carried out surgical treatment.

Outcomes:
The patient recovered well after the operation and was discharged on the 11th postoperative day. Blood β-human chorionic gonadotropin (β-hCG) levels and routine blood test results were normal 1 month after the surgery, and the patient had recovered.

Lessons:
Several challenges are encountered in the diagnosis of abdominal pregnancy with regard to insufficient economic, cultural, and medical resources. In case of ectopic pregnancies, surgery should be the first choice of treatment, and preparations of blood transfusion are essential to combat the risk of rapid hemorrhagic shock caused by placenta implantation in the infundibulum ligament of the pelvis. The operation must be performed by experienced obstetricians and gynecologists.
A bibliometric and visual analysis of research trends and hotspots of myocardial apoptosis: A review
Authors: Lian Kun , Li Xin , Wang Xiaoyi , Wang Fei , Yang Meng , Ye Jiahao , Li Lin , Hu Zhixi 
Published: September 2023

Background:
Recent studies have found that cardiomyocyte apoptosis is closely associated with the pathophysiological development of various cardiovascular diseases, for example chronic heart failure and myocardial infarction. At present, there are many researches in this field, such as pharmacological research, traditional Chinese medicine intervention research and pathway research. However, the relevant research is fragmented, with few comprehensive analysis and systematic combing.

Methods:
The relevant literature on cardiomyocyte apoptosis was downloaded from the Web of Science Core Collection (WoSCC) and PubMed databases. Citespace 6.1.R2 software Microsoft Excel 2019 and VOSviewer1.6.18.0 were used for bibliometric and visual analysis of publication volume, countries, institutions, journals, authors, keywords.

Results:
Since 1996, there are 1881 research articles and reviews related to cardiomyocyte apoptosis published by 10,313 researchers from 1648 institutions in 58 countries or regions were included. The number of annual publications showed an upward trend, especially in recent years. Countries participating in this research area include China, the United States, and Japan. Capital Medical University, Harbin Medical University are the key research institution, and other institutions also have substantial contribution on the project as to cardiomyocyte apoptosis. The journal EUR REV MED PHARMACO has a large number of publications, whereas CIRCULATION has the highest number of co-citations. Keywords analysis showed that apoptosis, expression and oxidative stress had higher frequencies, leading to 8 clusters.

Conclusions:
Cardiomyocyte apoptosis is a hot research field in recent years. Through visualization and bibliometric analysis, it is found that this field focus on hotspots like clinical manifestations including heart failure or myocardial infarction, and microscopic mechanisms such as oxidative stress and inflammation.
Study on the active ingredients and mechanism of Jiaotai Pill in the treatment of primary insomnia based on network pharmacology and GEO statistics: A review
Authors: Pan Limin , Wang Yaolei , Guan Ruiqian , Shi Qingchun 
Published: September 2023

Objective:
To explore the active components and mechanism of Jiaotai Pill (JTP) in the treatment of primary insomnia (PI) based on gene expression omnibus.

Methods:
The main active components of Jiaotai Pills were obtained by TCMSP and literature mining, and the targets of the active components of Jiaotai Pills were predicted. The targets were verified and standardized by Uniprot database. PI-related targets were obtained from GeneCards, OMIM, DrugBank, PharmGKB, and TTD databases. Obtaining an intersection action target point of the Jiaotai pill and the PI by using a Venny diagram; Gene chip data (GSE208668) was downloaded from gene expression omnibus database, and then gene probe enrichment analysis (GSEA) was used to screen the differentially expressed genes between PI patients and normal controls, and molecular docking was used to virtually verify the screened differentially expressed genes with potential active compounds.

Results:
21 active components and 263 potential targets of Jiaotai Pill were screened by database analysis and literature mining, 112 of which were intersected with PI. Molecular docking results showed that quercetin, EGCG, kaempferol, R-kanatin, stigmasterol, berberine and other core active components had good docking activity with related differential genes.

Conclusion:
Jiaotai Pill can regulate the release of inflammatory factors through multiple active ingredients, multiple disease targets, multiple biological pathways and multiple pathways to achieve the purpose of treating PI, which provides a theoretical basis for the clinical treatment of PI and broadens the clinical use of Jiaotai Pill.
Cap-assisted colonoscopy can increase the rate of sessile serrated lesion detection at the left lateral decubitus position: A retrospective case-control study
Authors: Nishimoto Satomi , Kudo Takahiro , Horiuchi Ichitaro , Yabe Kiyoaki , Kurasawa Shingo , Horiuchi Akira 
Published: September 2023

We investigated the effectiveness of cap-assisted colonoscopy conducted with the patient in the left lateral decubitus position at both the colonoscope’s insertion and withdrawal timepoints compared to the effectiveness of colonoscopy without a cap conducted in the supine position at withdrawal.
This was a case-control study, based on historical comparisons of patients over 2 time periods. The first group of patients underwent colonoscopies with a transparent cap and the patient was in the left lateral decubitus position at both the insertion and withdrawal timepoints from April to June 2019. The subsequent group underwent colonoscopies without a cap and with the patient in the supine position at withdrawal from July to September 2019. The rates of successful intubation, cecal intubation time, and number, size, shape, and location of the detected adenomas and sessile serrated lesions were compared between the 2 groups. Data from 644 colonoscopies (cap-assisted colonoscopy + left lateral decubitus position, n=320; other colonoscopies, n=324) were analyzed. The demographic characteristics and technical performances were similar. The SSL detection rate was significantly higher with cap-assisted colonoscopy and the left lateral decubitus position than with other colonoscopies (3.4% vs 0.93%, P=.029). The adenoma detection rates in the 2 groups were similar (31% and 28%, respectively, P=.43).Cap-assisted colonoscopy in the left lateral decubitus position may increase the detection rate of sessile serrated lesions compared to colonoscopy without a cap and supine position at withdrawal.
E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4
Authors: Chen Chao , Wang Ying , Zhao Qing , Li Guo-dong , Wang Yao-hui , Xu Li-chao , Huang Hao-zhe , Song Ge , Li Wen-tao , He Xin-hong 
Published: September 2023

Objective
The role E3 ubiquitin ligase membrane-associated RING-CH 8 (MARCH8) has not been studied in pancreatic cancer.

Method
Pancreatic cancer cell lines and the normal pancreatic cells were tested in vitro studies and male athymic nude mice were tested in vivo studies. Measuring cell viability by Cell Counting Kit-8 assay (CCK8), 5-ethynyl-2′- deoxyuridine (Edu) staining, and colony formation assay. Wound healing assay was implemented for cell migration and Transwell assay was performed for cell invasion to evaluate the histological status by hematoxylin and eosin staining and to detect the protein ubiquitination by ubiquitination assay. The protein expression was determined by immunohistochemistry staining and western blotting, and mRNA expression was measured by quantitative reverse transcription polymerase chain reaction.

Result
The expression of MARCH8 was increased whereas PTPN4 was decreased in pancreatic cancer cells. Overexpression of MARCH8 promoted the growth, migration, and invasion of cells, and knockdown of PTPN4 had the similar effects both in vitro and in vivo. MARCH8 promoted PTPN4 protein degradation through ubiquitination. Moreover, PTPN4 suppressed the transcription activities of STAT3 by impairing the level of pSTAT3 (705), while inhibition of PTPN4 activated phosphorylation of STAT3.

Conclusions
MARCH8 promoted pancreatic cancer growth and invasion through mediating the degradation of PTPN4 and activated the phosphorylation of STAT3.
Evidence-based management of adult traumatic brain injury with raised intracranial pressure in intensive critical care unit at resource-limited settings: a literature review
Authors: Gedeno Kanbiro , Neme Derartu , Jemal Bedru , Aweke Zemedu , Achule Astemamagn , Geremu Kuchulo , Bekele Uddo Tesfanew 
Published: September 2023

Background:
In underdeveloped countries, there is a greater incidence of mortality and morbidity arising from trauma, with traumatic brain injury (TBI) accounting for 50% of all trauma-related deaths. The occurrence of elevated intracranial pressure (ICP), which is a common pathophysiological phenomenon in cases of TBI, acts as a contributing factor to unfavorable outcomes. The aim of this systematic review is to analyze the existing literature regarding the management of adult TBI with raised ICP in an intensive critical care unit, despite limited resources.

Methods:
This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis protocol. Search engines such as PubMed, the Cochrane database, and Google Scholar were utilized to locate high-level evidence that would facilitate the formation of sound conclusions.

Result:
A total of 11 715 articles were identified and individually assessed to determine their eligibility for inclusion or exclusion based on predetermined criteria and outcome variables. The methodological quality of each study was evaluated using recommended criteria. Ultimately, the review consisted of 51 articles.

Conclusion:
Physical examination results and noninvasive assessments of the optic nerve sheath diameter (ONSD) via sonography are positively associated with elevated ICP, and are employed as diagnostic and monitoring tools for elevated ICP in resource-limited settings. Management of elevated ICP necessitates an algorithmic approach that utilizes prophylactic measures and acute intervention treatments to mitigate the risk of secondary brain injury.
HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis
Authors: Xu Lin , Yu Guohua , Jiang Lei , Song Xiao , Qu Guimei , Luo Jie , Cai Li 
Published: September 2023

Objective:
To investigate the expression and clinical significance of HepPar1 and GATA-3 in neuroendocrine neoplasms (NENs).

Materials and methods:
The expression of HepPar1 and GATA-3 in 144 cases of NENs was detected using immunohistochemistry, and the relevant literature was reviewed.

Results:
HepPar1 was localized in the cytoplasm, and the positive rate of HepPar1 was 6.25% (9/144) in 144 NENs, 9 of which were derived from gastrointestinal and pancreatic NENs, including 4 cases of neuroendocrine tumor, grade 1 (NET G1), 4 cases of NET G2, and 1 case of NET G3. GATA-3 was localized in the nucleus; the positive rate of GATA-3 was 7.62% (11/144), which was derived from 5 cases of gastrointestinal and pancreatic NENs, 2 cases of the lung, 2 cases of the liver, 1 case of the testis, and 1 case of the mediastinum. HepPar1 and GATA-3 were coexpressed in 4 cases: 2 cases of gastric NET G1, 1 case of gastric NET G2, and 1 case of pancreatic NET G3 with liver metastasis.

Conclusions:
HepPar1 and GATA-3 can be expressed in NENs, which are potential traps for the pathologic and differential diagnosis of tumors.
What Do We Know About Patient Safety Culture in Saudi Arabia? A Descriptive Study
Authors: Alaska Yasser A. , Alkutbe Rabab B. 
Published: September 2023

Background
Patient safety is described as the prevention and mitigation of medical errors that can result in harm while a patient is receiving care. One important way to improve safety is through improving the patient safety culture in healthcare. The purposes of this study are to evaluate the patient safety culture trend in Saudi Arabia and assess the improvement over time.

Methods
This study is a descriptive study that used a retrospective analysis of a national data set for 3 cycles from 2019 to 2022. To generate a baseline and allow comparison of the hospital’s survey results with the aggregated findings from the database, the 10th, 25th, 50th, 75th, and 90th percentiles were calculated to set the percentage of values.

Result
Our results found that one of the barriers to developing a strong patient safety culture in Saudi Arabia is management support of patient safety, which caused a blame culture. This could explain the absence of improvement in the average percentage of reporting patient safety events for all 3 cycles. On the other hand, a decrease was observed in organizational learning/continuous improvement as well as a reduction in the positive percentage of patient safety ratings in the last cycle. Moreover, areas of strength in all 3 cycles did not reach the 75th percentile, whereas staffing and response to error domains remained the lowest-scoring composites in all cycles.

Conclusion
Our results have determined the percentile of the positive rate that could guide hospitals to improve their culture survey results. More investigations can focus on change over the years in both patient safety culture and the effectiveness of implementing interventions to measure the impact on quality of care.
Malpractice Trends Involving Active Surveillance Across Cancers
Authors: Chang Samuel , Daskivich Timothy J. , Vasquez Missael , Sacks Wendy L. , Zumsteg Zachary S. , Ho Allen S. 
Published: September 2023

Objective:
To characterize malpractice trends related to active surveillance (AS) as a treatment strategy across cancers.

Background:
Active surveillance is increasingly considered a viable management strategy for low-risk cancers. Since a subset of AS cases will progress, metastasize, or exhibit cancer-related mortality, a significant barrier to implementation is the perceived risk of litigation from missing the window for cure. Data on malpractice trends across cancers are lacking.

Methods:
Westlaw Edge and LexisNexis Advance databases were searched from 1990-2022 for malpractice cases involving active surveillance in conjunction with thyroid cancer, prostate cancer, kidney cancer, breast cancer, or lymphoma. Queries included unpublished cases, trial orders, jury verdicts, and administrative decisions. Data were compiled on legal allegation, procedure performed, and verdict or settlement rendered.

Results:
Five prostate cancer cases were identified that pertained to active surveillance. Two cases involved alleged deliberate indifference from AS as a management strategy but were ruled as following appropriate standard of care. In contrast, three cases involved alleged physician negligence for not having explicitly recommended AS as a treatment option, after complications from surgery occurred. All cases showed documented informed consent for AS, leading to defense verdicts for the physicians. No cases of AS-related malpractice were identified for other cancer types.

Conclusions:
To date, no evidence of successful malpractice litigation for active surveillance in cancer has been identified. Given the legal precedent detailed in the identified cases and increasing support across national guidelines, active surveillance represents a sound management option in appropriate low-risk cancers, with no increased risk of medicolegal exposure.
Clinical evidence and mechanisms of traditional Chinese medicine in major diseases
Authors: Luo Binyu , Li Yiwen , Wang Wenting , Liu Yanfei , Xian Yanfang , Liu Yue , Chen Keji 
Published: September 2023

Abstract
Major diseases cause a double blow to patients' physical and mental health and family life and pose a great challenge to the healthcare system. The high incidence of major diseases compels us to constantly improve the medical prevention and treatment system to reduce disability and death rates as much as possible. Traditional Chinese medicine (TCM) has been widely used in the treatment of malignancies and cardiovascular and cerebrovascular diseases such as myocardial infarction and stroke, in the rehabilitation of patients with these diseases, as well as in the prevention and treatment of new outbreaks of infectious diseases and other major illnesses. After the coronavirus disease 2019 outbreak, the clinical application of “three prescriptions and three drugs” has greatly increased the cure rate, reduced the mortality rate, and provided a “Chinese solution” for global epidemic prevention and control. This article reviewed the clinical evidence and mechanisms of action of TCM in the prevention and treatment of major diseases, summarized the advances, and proposed future research directions to provide scientific evidence to expand the clinical application of TCM and improve its efficacy for the benefit of all humankind.
Association of Cognitive Deficits with Sociodemographic Characteristics among Adults with Post-COVID Conditions: Findings from the United States Household Pulse Survey
Authors: Wu Daniel J , Liu Nianjun 
Published: September 2023

AbstractBackgroundPeople infected with COVID-19 may continue to experience symptoms for several weeks or even months after acute infection, a condition known as long COVID. Cognitive problems such as memory loss are among the most commonly reported symptoms of long COVID. However, a comprehensive evaluation on the risks of cognitive decline following COVID infection among different sociodemographic groups has not been undertaken at the national level in the United States.MethodsWe conducted a secondary analysis on the datasets from U.S. Census Bureau Household Pulse Survey, encompassing the data collected from June 1, 2022 to December 19, 2022. Based on a cohort of 385,370 individuals aged 18 or older, we employed logistic regression analyses to examine the association between self-reported cognitive deficits and different sociodemographic factors among individuals with long COVID conditions.ResultsAmong individuals aged 18 or older, 44.7% percent of survey respondents report having been diagnosed with COVID in the past, and 29.0% of those with previous COVID infection experienced long COVID symptoms lasting for more than 3 months. We have demonstrated that individuals with long COVID had significantly higher risk of experiencing cognitive deficits compared to those with no history of COVID infection. Furthermore, females, young adults, people with multiple races, or low levels of education attainment are at high risk of cognitive deficits if they experience long COVID. At the state level, the prevalence of cognitive deficits among long COVID patients varied across different US states, with the highest prevalence in West Virginia and Kentucky, and the lowest prevalence in Connecticut and Maryland. The variation could be due to differences in racial composition and education level among long COVID patients in the four states.ConclusionsThe risks of cognitive deficits among adults with post-COVID conditions are substantial. Various sociodemographic groups can have different risks of developing cognitive deficits after experiencing long COVID. Findings of this large-scale study can help identify sociodemographic groups at higher risk of cognitive deficits, and facilitate medical interventions and guide resource allocation to target populations at risk and to prioritize areas with a high rate of cognitive decline.