bluuebunny/crossref_metadata_2025_split huggingface dataset:
Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG)
Authors: Müller Britta , Gaul Charly , Reis Olaf , Jürgens Tim P. , Kropp Peter , Ruscheweyh Ruth , Straube Andreas , Brähler Elmar , Förderreuther Stefanie , Schroth Jennifer , Dresler Thomas 
Published: April 2023

Abstract
Backgound
Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socioeconomic status (SES) of headache sufferers.

Methods
Data stem from a random general population sample in Germany. Respondents who reported having headache for at least a year and were aged ≥ 18 years were included in the study. A standardized questionnaire addressing headache and headache treatment was filled in during the face-to-face survey. The impact of headache on daily life was measured using the German version of the Headache Impact Test (HIT-6).

Results
Higher headache impact was found in low and medium SES compared to high SES. After adjustment for sociodemographics, headache-related factors (analgesic use, headache duration, headache frequency, migraine diagnosis), depressive symptoms, physical inactivity and obesity, an increased odds ratio of having higher headache impact in low SES compared to high SES was found: OR = 1.83, 95% CI [1.43, 2.23], p = .014. When the interactions "SES*obesity", "SES*depressive symptoms", and "SES*physical inactivity" were added, the results showed a significant interaction effect of “SES*obesity”. Obese persons with low SES were 3.64 times more likely to have higher headache impact than non-obese persons with low SES. No significant differences between obese and non-obese persons were found in the medium and high SES groups.

Conclusions
SES is an important factor that should not be neglected in headache awareness campaigns and headache treatment. Longitudinal studies are needed in the future to investigate whether lifestyle interventions, such as weight reduction, can help to reduce headache impact in people in lower SES.
Short sleep duration associated with the incidence of cardio-cerebral vascular disease: a prospective cohort study in Shanghai, China
Authors: Ke Juzhong , Liu Xiaolin , Ruan Xiaonan , Wu Kang , Qiu Hua , Wang Xiaonan , Li Zhitao , Lin Tao 
Published: April 2023

Abstract
Importance
Sleep duration plays an important role in predicting CCVD incidence, and have implications for reducing the burden of CCVD. However, the association between sleep duration and predicted cardio-cerebral vascular diseases (CCVD) risk remains to be fully understood.

Objective
To investigate the effects of sleep duration on the development of CCVD among Chinese community residents.

Design
A prospective cohort study. The baseline survey was conducted from January 2013 to July 2013. The cohort has been followed until December 31, 2016 using a combination of in-person interviews and record linkages with the vital registry of Pudong New Area, Shanghai, China.

Subjects
A total of 8245 Chinese community residents were initially enrolled in the cohort. Of those, 6298 underwent the follow-up examination.

Exposure
Self-reported sleep duration and sleep quality were obtained via the questionnaire. Sleep duration was divided into five categories: ≤5, 6, 7, 8, or ≥ 9 h per day.

Main Outcome(s) and Measure(s)
CCVD, Coronary heart disease (CHD) and Stroke occurrence, Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Fine-Gray proportional subdistribution hazards models.

Results
During a median follow-up of 3.00 years (IQR 2.92–3.08), we observed 370 participants have had incident CCVD events, of whom 230 had CHDs, 169 had strokes, and 29 had both. After adjustment for relevant confounders, short sleepers (≤ 5 h) had 83% higher risk of total CCVD incidence (HR: 1.83; 95% CI: 1.32–2.54), 82% higher risk of CHD incidence (HR: 1.82; 95% CI: 1.21–2.75), and 82% higher risk of stroke incidence (HR: 1.82; 95% CI: 1.12–2.98) in contrast to the reference group (7 h). Some of these U-shaped relationships varied by age, and were more pronounced in individuals aged < 65 years. Individuals who slept ≤ 5 h per day with baseline hypertension had the highest risk of CCVD incidence (HR: 3.38, 95% CI 2.08–5.48), CHD incidence (HR: 3.11, 95% CI 1.75–5.53), and stroke incidence (HR: 4.33, 95% CI 1.90–9.86), compared with those sleep 7 h and without baseline hypertension.

Conclusions
Short sleep duration is independently associated with greater incidence of CCVD, CHD and stroke.
Integrated pancancer analysis reveals the oncogene characteristics and prognostic value of DIP2B in breast cancer
Authors: Song Chengyang , Shang Fangjian , Tu Wei , Liu Xiaodan 
Published: April 2023

Abstract
Background
Disco-interaction protein 2 homologue B (DIP2B) plays an important role in DNA methylation. There have been many reports on DIP2B in various diseases, but neither the diagnostic value nor the prognostic value of DIP2B across cancer types has been deeply explored.

Methods
The expression levels of DIP2B in 33 cancer types were analysed based on data sets from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database. The relationships of DIP2B expression with immune cell infiltration and immune-related gene expression were studied via the CIBERSORT, ESTIMATE and TISIDB tools. Gene set variation analysis (GSVA) was performed to identify pathways related to DIP2B. DIP2B knockdown by siRNA was performed in breast cancer cell lines to investigate the effect on proliferation, apoptosis and migration. The relationships of DIP2B expression with clinicopathological features and prognosis were analysed based on immunohistochemistry.

Results
DIP2B was highly expressed in 26 of 33 cancer types and was significantly associated with poor overall survival (OS) in breast invasive carcinoma (BRCA), mesothelioma and chromophobe renal cell carcinoma (each P < 0.05). DIP2B showed a negative correlation with the immune score, the infiltration levels of key immune killer cells (CD8 + T cells, activated NK cells and plasma cells), and the expression of major histocompatibility complex–related genes and chemokine-related genes in BRCA. Subtype analysis showed that DIP2B expression was associated with poor OS in Her-2 + BRCA patients (P < 0.05). DIP2B showed a negative correlation with immune killer cell infiltration and immune regulatory genes in BRCA subtypes. In BRCA, the GSVA results revealed that genes correlating positively with DIP2B were enriched in cancer-related pathways (PI3K-AKT) and cell-cycle-related pathways (MITOTIC_SPINDLE, G2M_CHECKPOINT and E2F_TARGETS), while genes correlating negatively with DIP2B were enriched in DNA_REPAIR. Knockdown of the DIP2B gene induced a reduction in proliferation and migration and an increase in apoptosis in breast cancer cell lines. DIP2B expression was associated with lymph node metastasis and poor histological grade in BRCA according to immunohistochemistry (each P < 0.05). DIP2B expression predicted reduced disease-free survival and OS in BRCA patients (each P < 0.05), especially those with the Her-2 + subtype (P = 0.023 and P = 0.069).

Conclusions
DIP2B may be a prognostic biomarker for BRCA, especially for the Her-2 + subtype. DIP2B is associated with a “cold” tumour immune microenvironment in BRCA and might serve as a future target for immunotherapy.
Prevalence and effects of menstrual disorders on quality of life of female undergraduate students in Makerere University College of health sciences, a cross sectional survey
Authors: Odongo Emmanuel , Byamugisha Josaphat , Ajeani Judith , Mukisa John 
Published: April 2023

AbstractBackgroundMenstrual problems affect as high as 90% of adolescent females and are the main reason for gynecology visits. Dysmenorrhea was the most frequent menstrual disorder for which adolescents and their parents were referred to a physician. Many undergraduate students are adolescents who undergo several hormonal changes that affect menstrual patterns. This study aimed to determine the prevalence of menstrual disorders and to determine the effect of menstrual disorders on quality of life (QOL) of female undergraduate students at Makerere University college of health sciences.MethodsA cross sectional study design using a self-administered questionnaire. WHO (World Health Organization) QOL-BREF (QOL-Best Available Reference document) questionnaire was used to assess QOL of participants. Collected data was double entered into EPIDATA, and transferred to STATA for analysis. Data was presented using tables, and analyzed using percentages, frequencies, medians, interquartile range, means and standard deviations, t-test and ANOVA were used to establish statistical significance.P < 0.05 was considered statistically significant.ResultsOf the participants, 275 were included in the data analysis. The median age of the participants was 21 years with range of 18–39 years and interquartile range of 20–24 years. All the participants had attained menarche. Of the participants, 97.8% (95%CI: 95.2–99.0) (269/275) reported some form of menstrual disorder. Premenstrual symptoms were the commonest disorder (93.8% (95%CI: 90.2–96.1),N = 258) followed by dysmenorrhea (63.6% (95% CI: 57.7–69.1),N = 175), irregular menstruation (20.7% (95%CI: 16.3–25.9),N = 57), frequent menstruation (7.3% 95% CI:4.7–11.0,N = 20) and infrequent menstruation (3.3% (95% CI:1.7–6.2),N = 9). Dysmenorrhea and premenstrual symptoms significantly reduced the QOL scores of participants.ConclusionMenstrual disorders were highly prevalent with negative effects on QOL and class attendance. Efforts should be made to screen and possibly treat menstrual disorders among university students as well as to conduct further studies to elucidate more on the effects of menstrual disorders on quality of life.
Evaluation of initial patient setup methods for breast cancer between surface-guided radiation therapy and laser alignment based on skin marking in the Halcyon system
Authors: Kang Seonghee , Jin Hyeongmin , Chang Ji Hyun , Jang Bum‑Sup , Shin Kyung Hwan , Choi Chang Heon , Kim Jung-in 
Published: April 2023

Abstract
Background
This study was conducted to evaluate the efficiency and accuracy of the daily patient setup for breast cancer patients by applying surface-guided radiation therapy (SGRT) using the Halcyon system instead of conventional laser alignment based on the skin marking method.

Methods and materials
We retrospectively investigated 228 treatment fractions using two different initial patient setup methods. The accuracy of the residual rotational error of the SGRT system was evaluated by using an in-house breast phantom. The residual translational error was analyzed using the couch position difference in the vertical, longitudinal, and lateral directions between the reference computed tomography and daily kilo-voltage cone beam computed tomography acquired from the record and verification system. The residual rotational error (pitch, yaw, and roll) was also calculated using an auto rigid registration between the two images based on Velocity. The total setup time, which combined the initial setup time and imaging time, was analyzed to evaluate the efficiency of the daily patient setup for SGRT.

Results
The average residual rotational errors using the in-house fabricated breast phantom for pitch, roll, and yaw were 0.14°, 0.13°, and 0.29°, respectively. The average differences in the couch positions for laser alignment based on the skin marking method were 2.7 ± 1.6 mm, 2.0 ± 1.2 mm, and 2.1 ± 1.0 mm for the vertical, longitudinal, and lateral directions, respectively. For SGRT, the average differences in the couch positions were 1.9 ± 1.2 mm, 2.9 ± 2.1 mm, and 1.9 ± 0.7 mm for the vertical, longitudinal, and lateral directions, respectively. The rotational errors for pitch, yaw, and roll without the surface-guided radiation therapy approach were 0.32 ± 0.30°, 0.51 ± 0.24°, and 0.29 ± 0.22°, respectively. For SGRT, the rotational errors were 0.30 ± 0.22°, 0.51 ± 0.26°, and 0.19 ± 0.13°, respectively. The average total setup times considering both the initial setup time and imaging time were 314 s and 331 s, respectively, with and without SGRT.

Conclusion
We demonstrated that using SGRT improves the accuracy and efficiency of initial patient setups in breast cancer patients using the Halcyon system, which has limitations in correcting the rotational offset.
Current trends in graft choice for primary anterior cruciate ligament reconstruction – part II: In‐vivo kinematics, patient reported outcomes, re‐rupture rates, strength recovery, return to sports and complications
Authors: Runer Armin , Keeling Laura , Wagala Nyaluma , Nugraha Hans , Özbek Emre Anil , Hughes Jonathan D. , Musahl Volker 
Published: April 2023

AbstractPostoperative patient satisfaction after anterior cruciate ligament reconstruction (ACL‐R) is influenced mainly by the degree of pain, the need for reoperation, and functional performance in daily activities and sports. Graft choice has shown to have an influence on postoperative outcomes after ACL‐R. While patient reported outcomes measurements do not differ between graft options, evidence shows that normal knee kinematics is not fully restored after ACL‐R with an increase in postoperative anterior tibial translation (ATT). Postoperative graft rupture rates seem to favor bone‐patella‐tendon‐bone (BPTB) and quadriceps tendon (QT) autografts over HT or allografts. While return to sports rates seem comparable between different graft types, postoperative extensor strength is reduced in patients with BPTB and QT whereas flexion strength is weakened in patients with HT. Postoperative donor site morbidity is highest in BPTB but comparable between HT and QT. With all graft options having advantages and drawbacks, graft choice must be individualized and chosen in accordance with the patient.
A comparative study of big data use in Egyptian agriculture
Authors: Sayed Sayed A. , Mahmoud Amira S. , Farg Eslam , Mohamed Amany M. , Saleh Ahmed M. , AbdelRahman Mohamed A. E. , Moustafa Marwa , AbdelSalam Hisham M. , Arafat Sayed M. 
Published: April 2023

AbstractThe Egyptian economy relies heavily on the agricultural sector. As the population grows, arable land will diminish in the next decades. This makes food supply a priority. Big data could help the agriculture sector to address food security, especially in Egypt. In this paper, we examined the role of big data in agriculture in response to three questions: (1) What are the trend in peer-reviewed papers in the field of business development modeling and management? (2) What approaches were widely used especially in underdeveloped countries? (3) What is the current gap in terms of data sources, modeling, and analytic methods? As a result, 242 peer-reviewed articles have been studied. The contribution and findings of this study are summarized as. (1) A briefing on popular approaches which used frameworks was provided. (2) Publications based on the Internet of Things (IoT) in agriculture have increased dramatically by about 27%, 40%, and 44% in the years 2017, 2018, and 2019, respectively. (3) Around 37% of publications used Landsat and Sentinel-2 satellite images to build popular vegetation indices and land cover maps. (4) The challenges were identified as well as substantial opportunities that might serve as a roadmap for future growth. Therefore, by performing a comparative study in big data from this perspective, we explored the design principles using artificial intelligence and discussed a converged architecture to address the above-mentioned challenges.
Comparative evaluation of pH and Ca+ ion release from MTA on interaction with platelet-rich fibrin and blood clot: an in vitro study
Authors: Khatri Sonia , Mathew Sylvia , Nagaraja Shruthi , Hegde Swaroop , Ghosh Soumyadeep , Ravichandran Kavimalar 
Published: April 2023

Background: ‘Regenerative endodontics’ using host-derived scaffolds and biomaterials (MTA) is popular in the management of teeth with open apex. Alkaline pH and bioactivity contribute to tissue healing and remineralization. We assessed the influence of PRF and Blood Clot on the pH and Ca+ ion release from MTA. Methods: A total of 15 single-rooted human extracted teeth were sectioned at the level of the cementoenamel junction. Based on the type of scaffolds used, samples were divided into three groups. Group 1 (MTA+ PRF), Group 2 (MTA + Blood Clot), Group 3 (control MTA). The prepared specimens were transferred to a fresh falcon tube containing 10mL of distilled water and the collected solutions were analysed for pH and Ca+ ion release at 3h, seventh day and 14th day. Results: It was observed that the mean pH and Ca+ ion release were significantly lower in the experimental groups as compared to the control group. Though there was an increase in the pH recorded in Group 1 and 2 at all time periods, the difference was not significant. Ca+ ion release peaked at Day 7 (Group3 > Group2 > Group1) and reduced significantly on the 14th day for all groups. Conclusions: Within the limitations of the study, it can be concluded that PRF and blood clot influence the pH and Ca+ ion release from MTA.
Growth performance and histological response of Clarias gariepinus raised on unprocessed dried leaves of Telfairia occidentalis and Mucuna utilis
Authors: Ajiboye Adebola O. , Tola-Fabunmi Adenike S. , Ayanboye Abolupe O. 
Published: April 2023

Nutrient utilization is determined by absorbable and digestible nutrients in fish feeds. The aim of the experiment was to investigate the effects of unprocessed dried leaves of Telfairia occidentalis (UDLTO) and Mucuna utilis (UDLMU) on histology and growth of C. gariepinus. Sixteen weeks feeding trial experiment was conducted using two hundred and twenty-five Clarias gariepinus with a mean weight 4.16±0.09g. Fish meal was replaced with 0, 25, 50, 75 and 100% levels of UDLMU and UDLTO. Growth parameters and histological examinations were carried out according to standard procedures. Mean Weight Gain (MWG) of 0% (15.8g) was significantly higher P0.05 compared to other treatments. Specific Growth Rate (SGR) of 0% (0.64) varied significantly P0.05 than other levels of inclusions. Kidneys of fish fed 25 and 50% graded levels showed patchy vacuolar degeneration of the renal tubules. Gills of fish fed 75 and 100% graded levels showed diffuse capillaries and moderate congestion of lamellar in the gills. Tissue examinations of fish fed 50, 75 and 100% graded levels exhibited clinical signs of moderate atrophy and vacuolation of hepatocytes and diffuse hepatocellular swelling and degeneration in the liver. Histological investigations revealed fragmentation and atrophy of muscle fibre in fish fed 75% graded level. There was moderate atrophy of villi of the intestine of fish fed 100% graded level. It is apparent that the increased levels of UDLMU and UDLTO could not support good growth as presumed due to the presence of anti-nutritional factors in the leaves.Keywords: Nutrient utilization, Fish meal, Inclusions, standard procedures, Clinical signs
Photonic integrated multicast switch-based optical wireless data center network
Authors: Zhang Shaojuan , Kraemer Rafael , Xue Xuwei , Tessema Netsanet , Freire Santana Henrique , Tangdiongga Eduward , Calabretta Nicola 
Published: April 2023

Optical wireless data center networks (OW-DCNs), which employ optical wireless technology and optical wired switching technology, are gaining interest as they promise to eliminate cable complexity, as well as to create high bandwidth interconnections and a low-cost and power-efficient system. In particular, the incorporation of optical tunable transmitters (T-TXs) and passive optical beam steering technologies is a promising way to build an OW-DCN benefitting from the potential of fast optical switching speed, low switch control complexity, and easy reconfiguration. However, the practical deployment of such an OW-DCN remains a challenge as fast (nanosecond) T-TX is required for fast optical switching operation. Implementation of fast T-TX can be realized by an array of lasers and optical gates, which are combined with photonic integration technology to achieve a compact, stable, and efficient nanosecond T-TX. In this paper, we propose an OW-DCN based on arrayed waveguide grating routers and fast T-TXs that exploit photonic integrated circuit multicast switches (PIC-MCSs). This PIC-MCS chip not only offers nanosecond-scale fast optical switching but also plays an essential role in enabling multicast operation, T-TX sharing, and dynamic bandwidth allocation between the intra- and inter-cluster networks. A 4×2 PIC-MCS has been designed, fabricated, and characterized in this proposed OW-DCN system. Experimental results validate that the proposed OW-DCN supports lossless, nanosecond, and multicast switching operation. Moreover, the dynamic bandwidth allocation and optical packet switching capability have been experimentally demonstrated. Finally, system performance with this fabricated PIC-MCS chip in a 4×4 rack OW-DCN is experimentally validated for different transmission scenarios and modulation formats. Wavelength division multiplexing multicast transmission with 50 Gb/s non-return-to-zero on–off-keying signals has been verified with less than 1.5 dB power penalty. 58 Gb/s four-level pulse-amplitude modulation transmission has also shown operation below the forward error correction threshold of 3.84×10−3 for all the different transmission scenarios.
Mental expression and inner speech
Authors: López Campillo Jesús 
Published: April 2023

This article explores the importance of mental expression in understanding the phenomenon of inner speech. Most accounts of inner speech assume from the outset the common idea that the expressions of a subject (e.g., a smile) and their mental states (e.g., joy) are two different types of items somehow related to each other. This relational view of expression is challenged in this article. Firstly, it is argued that relational views of expression cannot explain some features of inner speech. Secondly, a non-relational view of expression is developed, according to which mental states are patterns of expressive behavior. Thirdly, it is argued that only from the framework of non-relational expressivism is it possible to explain the main features of inner speech. Finally, it is concluded that non-relational expressivism emerges as a prominent contender among contemporary views of the mind, as it provides the only account of inner speech that can fully explain the phenomenon.