bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Clearance Between Cradle and Barrel on Nonlinear Dynamic Response of The Artillery System
Authors: Lu Shaojie , Gao Zhiying , Zhang Haifeng , Liao Maolin 
Published: July 2023

Abstract
The artillery weapon system,characterized as a complex nonlinear mechanical system , is influenced by various factors affecting its muzzle vibration response.Thus, taking the model of the artillery system with variable cross-section and multi-step barrel as the object, the equation of bending deformation of the barrel is obtained.Subsequently, the equation of the fundamental frequency of the vertical vibration of the muzzle is obtained based on Hooke’s law and Rayleigh method.And the reliability of both equation is verified by the modal testing and the FEM method under the constraint boundary.Then, the equivalent non-linear dynamic model of the vertical vibration of the muzzle is established ,considering the clearance between the barrel and cradle. Furthermore, the amplitude-frequency curves of the equivalent model under the sinusoidal excitation is obtained based on the multi-scale analysis method for analyzing the impact of clearance and sinusoidal excitation.Finally, the vibration research system of the model of the artillery system is constructed to study the vibration characteristics of the muzzle.The study shows that the proposed theoretical model of bending deformation and fundamental frequency exhibits a higher level of accuracy .In addition, the system demonstrates a reduction in stiffness and a escalation in the maximum amplitude of the amplitude-frequency curve with the increase of the magnitude of the excitation.While, the system demostrates a escalation in both the stiffness and the maximum amplitude with the increase of the clearance value.
Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment
Authors: Li Xuefei , Wang Yi , Chen Ziqiang , Ruan Ming , Yang Chan , Zhou Maolin , Li Ning , Xing Lianping , Xu Hao , Yang Ling , Shi Qi , Wang Yongjun , Chen Jinman , Liang Qianqian 
Published: July 2023

Abstract
Objective
To examine and quantify liver and kidney lesions and their response to anti-TNF therapy in TNF-Tg mouse model of rheumatoid arthritis.
Methods
Female TNF-Tg (Tg3647) mice were used as the animal model of chronic rheumatoid arthritis. Ultrasound, immunofluorescence and histology staining, serology test and real-time PCR were used to examine the pathological changes in liver and kidney.
Results
TNF-Tg mice showed a significant decrease in body weight and a dramatic increase in the volumes of gallbladder, knee cavity, and popliteal lymph nodes. Liver and kidney of TNF-Tg mice were demonstrated increased chronic inflammation, accumulation of immune cells, fibrosis and senescence, compared to the wide-type (WT) mice. Moreover, up-regulation of inflammatory factors and impaired normal function were also observed in the liver and kidney of TNF-Tg mice. The inflammation infiltration, fibrosis and senescence in liver and kidney of female TNF-Tg mice were improved after anti-TNF treatment, and better treatment effects were achieved at 8 weeks of intervention.
Conclusions
We found that TNF drives the development of liver and kidney pathology in female TNF-Tg mice, and there are limitations in the loss of utility of Anti-TNF for prolonged treatment of RA-associated hepatic and renal injury. This study provided a reliable and high clinically relevant animal model for the further study to explore the molecular mechanisms and drug discovery of hepatorenal pathologies in RA.
The societal economic impact of vision impairment in adults 40 years and above: Findings from the National Eye Survey of Trinidad and Tobago
Authors: Braithwaite Tasanee , Bailey Henry , Bartholomew Debra , Maharaj Vedatta , Fraser Amandi , Deomansingh Frank , Ramsewak Shivaa , Tripathi Vrijesh , Sharma Subash , Ramsewak Samuel , Bourne Rupert , Gray Alastair 
Published: July 2023

Abstract
Background
Understanding and mitigating the societal economic impact of vision impairment (VI) is important for achieving the Sustainable Development Goals.
Aim
To estimate the prevalent societal economic impact of presenting VI in Trinidad and Tobago using bottom-up cost and utilisation data from the 2014 National Eye Survey of Trinidad and Tobago.
Methods
We took a societal perspective to combine comprehensive, individual-level cost and utilisation data, with population-based prevalence estimates for VI, and additional data from a contemporaneous national eyecare system survey. We included direct (medical and non-medical) and indirect (productivity loss) costs, and intangible losses in total cost estimates, presented in 2014 Trinidad & Tobago(TT) dollars and UK sterling equivalent. We considered but excluded transfer payments and dead weight losses. Sensitivity analyses explored impact on total cost of parameter uncertainty and assumptions.
Results
Individual utilisation and cost data were available for 65.5%(n = 2792/4263) and 59.0%(n = 2516/4263) eligible participants aged ≥ 40 years, respectively. Participant mean age was 58.4(SD 11.8, range 40–103) years, 56.3% were female. We estimated total societal cost of VI in 2014 at UK£365,650,241 (TT$3,842,324,655), equivalent to £675 per capita (population ≥ 40 years). Loss of wellbeing accounted for 73.3%. Excluding this, the economic cost was UK£97,547,222 (TT$1,025,045,399), of which indirect costs accounted for 70.5%, followed by direct medical costs (17.9%), and direct non-medical costs (11.6%).
Conclusion
This study provides robust estimates of the economic impact of vision loss in a Caribbean country, and highlights the extent to which affected individuals and their families bear the societal economic cost of vision impairment.
Corrosion in reinforced concrete: Diagnostics through Potential Corrosion Technique
Authors: Reginato Lucas Alexandre , Lorenzi Alexandre , de Oliveira Leonardo Covatti , Lorenzi Luciani Somensi , Filho Luiz Carlos Pinto da Silva 
Published: July 2023

Abstract
Among the processes that accelerate the loss performance of reinforced concrete structures, considering their frequent occurrence and severity, reinforcement corrosion can be seen as one of the most important. A worrying factor is that most buildings in the Brazilian urban centers are between 40 and 50 years old, a time when repairs and maintenance become more routine. Therefore, the problems related to the corrosion of the reinforcements tend to accentuate in the coming years, and the identification of corrosion will play an important role. Thus, this research has the purpose to analyze the application of the diagnosis through potential corrosion techniques. For this, full-scale reinforced concrete beams were corrosion analyzed. Corrosion was stimulated by the Modified Immersion Accelerated Corrosion - CAIM method, at three levels of mass loss: 5, 10 and 15%. The diagnostic technique through the corrosion potential was applied, in which it was observed that there is uncertainty in the corrosion evaluation for the mass loss levels of 5 and 10%, resulting in a corrosion uncertainty interval, but at 15%, the potential technique proved to be satisfactory.
Harnessing the power of whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation
Authors: Lisowski Leszek , Cabanes-Creus Marti , Liao Sophia H.Y. , Navarro Renina Gale , Knight Maddison , Nazareth Deborah , Lau Ngee-Soon , Ly Mark , Zhu Erhua , Roca-Pinilla Ramon , Delgado Ricardo Bugallo , Baltazar Grober , Westhaus Adrian , Merjane Jessica , Crawford Michael , McCaughan Geoffrey , Ezquerro Carmen María Unzu , González-Aseguinolaza Gloria , Alexander Ian , Pulitano Carlo 
Published: July 2023

Abstract
Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to the complexity of the human liver. In this work, we describe the application of whole human liver explants in an ex situ normothermic perfusion system to evaluate a set of fourteen natural and bioengineered adeno-associated viral (AAV) vectors directly in human liver, in the presence and absence of neutralizing human sera. Under non-neutralizing conditions, the recently developed AAV variants, AAV-SYD12 and AAV-LK03, emerged as the most functional variants in terms of cellular uptake and transgene expression. However, when assessed in the presence of human plasma containing anti-AAV neutralizing antibodies (NAbs), vectors of human origin, specifically those derived from AAV2/AAV3b, were extensively neutralized, whereas AAV8- derived variants performed efficiently. This study establishes the use of normothermic liver perfusion as an invaluable preclinical model for evaluating liver-targeted gene therapies and providing guidance for making essential decisions that promote the most effective translational programs.
Significance of phosphorus leaching during potato production in coarse soil
Authors: Liu Xiaoyu , Ma Zhong , Qin Yonglin , Shi Xiaohua , Yu Jing , Jia Liguo , Fan Mingshou 
Published: July 2023

Abstract
Phosphorus (P) loss through vertical leaching has been considered insignificant in potato production in Inner Mongolia of China. However, the coarse-textured soil in this potato production region has lower water and nutrient retention capacity, which may result in significant P leaching, leading to increased environmental risk and lower P-use efficiency in potato production. The objective of this study was to evaluate phosphorus leaching in coarse soil during potato production under varied phosphorus application rates and irrigation volumes in Inner Mongolia, by collecting leachate from 60 cm deep soil. Results obtained over the course of four years indicate that accumulative P leaching during the potato production ranged from 0.61 to 4.67 kg/ha, and it increased significantly with increasing P application rate or irrigation volume. This P leaching is of concern to both crop production and the health of aquatic ecosystems, it suggests it is of importance to develop both P fertilizer management and irrigation technique for diminishing P leaching and improving P-use efficiency in potato production on coarse soil.
RETRACTED: Impact of germination conditions on nutritional, nutraceutical, functional and anti-nutritional factors of Pseudocereals grown in Northern Himalayas
Authors: Bhat Tashooq , Habib Huraiya , Kumar Ashwani , Amin Tawheed , ALI GOWHAR , HAMID AFLAQ 
Published: July 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Hyperphosphorylated tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine
Authors: Song Zhenfeng , Wang Kuang-Wei , Hagar Hsiao-Tien Chien , Chen Hong-Ru , Kuan Chia-Yi , Zhang Kezhong , Kuo Min-Hao 
Published: July 2023

Abstract
Background Abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for Alzheimer’s disease and additional neurodegenerative tauopathies. However, how hyperphosphorylated tau causes cellular dysfunction or death that underlie neurodegeneration remains an unsolved question critical for the understanding of disease mechanism and the design of efficacious drugs.Methods Using a recombinant hyperphosphorylated tau protein (p-tau) synthesized by the PIMAX approach, we examined how cells responded to the cytotoxic tau and explored means to enhance cellular resistance to tau attack.Results Upon p-tau uptake, the intracellular calcium levels rose promptly. Gene expression analyses revealed that p-tau potently triggered endoplasmic reticulum (ER) stress, Unfolded Protein Response (UPR), ER stress-associated apoptosis, and pro-inflammation in cells. Proteomics studies showed that p-tau diminished heme oxygenase-1 (HO-1), an ER stress-associated anti-inflammation and anti-oxidative stress regulator, while stimulated the accumulation of MIOS and other proteins. P-tau-induced ER stress-associated apoptosis and pro-inflammation are ameliorated by apomorphine, a brain-permeable prescription drug widely used to treat Parkinson’s disease symptoms, and by overexpression of HO-1.Conclusion Our results reveal probable cellular functions targeted by hyperphosphorylated tau. Some of these dysfunctions and stress responses have been linked to neurodegeneration in Alzheimer's disease. The observations that the ill effects of p-tau can be mitigated by a small compound and by overexpressing HO-1 that is otherwise diminished in the treated cells inform new directions of Alzheimer's disease drug discovery.
MI2T-UNet: Integrating Multi-Scale Input Image and Top-hat Context for Infrared Small Object Segmentation
Authors: Shah Imad Ali , Khalil Ihsan Ullah , Shah Mian Ibad Ali , Mohamed Nachaat , Ali Enas , Ghoneim Sherif S. M 
Published: July 2023

Abstract
The segmentation of small objects in the infrared spectrum, commonly referred to as Infrared Small Object Segmentation (ISOS), holds significant importance in many applications, including but not limited to target detection, surveillance, and autonomous navigation. The task of achieving precise image segmentation of objects of interest is formidable, owing to the diminutive size of the objects in question, the intricate nature of the background, and the limited contrast differential. This research introduces a novel mobile-UNet architecture with attention gates, namely MI2T-UNet, which leverages multi-scale input images and top-hat operation. The proposed methodology involves the implementation of architectural modifications to improve the scale adaptation of the model. Specifically, these modifications include concatenating down-scaled input images with corresponding encoder layers, utilizing multi-kernel top-hats in the encoders and attention gates, and integrating encoder outputs with subsequent encoder layers to facilitate progressive information flow. This article also compares the proposed architecture against the top-performing models on the SIRST and IRSTD datasets, utilizing metrics for pixel level such as IoU/NIoU, object level including Pd/Fa, and model level comprising F-Score/AUC. The experimental results demonstrate that MI2T-UNet outperforms state-of-the-art models in terms of segmentation, with an average margin of over 1±0.25% for evaluation metrics. This research contributes to the ISOS field by proposing a novel approach to enhance the discriminating ability of the network. Specifically, a modified mobile-UNet has been developed, tailored to the ISOS requirements. The proposed approach has the potential to make significant strides in infrared image analysis and streamline various applications that hinge on precise ISOS.
Serum Adipokines as Biomarkers for Surveillance of Metabolic Syndrome in Childhood Acute Lymphoblastic Leukemia/Lymphoma Survivors in Low Middle Income Countries
Authors: Das Gargi , Setlur Kritika , Jana Manisha , Ramakrishnan Lakshmy , Jain Vandana , Meena Jagdish Prasad , Gupta Aditya Kumar , Dwivedi Sada Nand , Seth Rachna 
Published: July 2023

Abstract
Background
Serum adipokines (leptin and adiponectin) are dysregulated prior to the onset of metabolic syndrome and hence may be useful biomarkers for screening of therapy related cardiometabolic late effects in childhood Acute Lymphoblastic Leukemia/Lymphoma (cALL) survivors. We conducted a study to compare serum levels of adipokines in cALL survivors and controls, and evaluated their role in prediction of metabolic syndrome in our cohort of survivors.
Methods
In a cross sectional study, we compared serum adipokine levels between 40 cALL survivors (aged 10–18 years, at least 2 years from treatment completion) with similar controls. A multivariable logistic regression analysis was done to assess association of metabolic syndrome in cALL survivors with independent variables including adipokines, demographic and treatment details, other metabolic parameters and Dual Energy Xray Absorptiometry scan derived variables.
Results
Compared to controls, cALL survivors had higher prevalence of metabolic syndrome (8/40 vs 2/40, p = 0.042) and central obesity (11/40 vs 4/40, p = 0.042). Median serum Leptin (7.39 vs 4.23ng/mL, p = 0.207) levels and derived Leptin-Adiponectin ratio (1.44 vs 0.80, p = 0.598), were higher but not statistically different in our survivors compared to controls; Adiponectin levels were similar (6.07 vs 5.01µg/ml, p = 0.283). In our cohort of cALL survivors, overweight/obesity [OR 21.9, p = 0.020] or higher Leptin levels [OR 1.11, p = 0.047)], were independently associated with metabolic syndrome.
Conclusions
Serum Leptin, independently predictive of metabolic syndrome in our cohort of cALL survivors, maybe tested in larger studies to assess its utility in surveillance. This may help initiate early preventive measures and in turn improve the quality of life of our survivors.
A complex presentation of hypermobility in a patient with an isolated ELN gene mutation and phenotype-genotype analysis of isolated ELN mutation variants: a case report and literature review
Authors: Monjazeb Ryan , Linjawi Hamad , Laukaitis Christina 
Published: July 2023

Abstract
Background:
Intragenic deletions in the elastin (ELN) gene have previously been associated with the cutis laxa phenotype and a variety of cardiovascular manifestations. However, the precise correlation between deletion location and observed phenotype has not been well reported. Even less reported are isolated ELN deletions causing a joint hypermobility phenotype that mimics hypermobile Ehlers-Danlos syndrome (hEDS). We present the case of a 28-year-old female with a hEDS phenotype resulting from an isolated deletion of exons 31-33 in the ELN gene, along with a literature review of 35 patients with partial ELN gene mutations that revealed a clear phenotype-genotype association between the exon containing variation and observed phenotype.
Case Presentation:
A 28-year-old female was referred to the genetics clinic for evaluation of joint hypermobility. Her parents are unrelated and of Northern European descent. Her family history was significant for sudden death, hernias, and hypermobility in family members. She presented with an array of symptoms that included joint pain, instability, and frequent dislocations, a history of easy bruising, and postural orthostatic tachycardia syndrome. Her past medical history was remarkable for bilateral bunions requiring surgical repair and a congenital cataract. An echocardiogram revealed non-specific thickening of the mitral valve leaflets with otherwise normal structure and function. Her physical exam was noteworthy for hyper-elastic skin and joint hypermobility with a Beighton score of 7/9. Analysis of a connective tissue disorders gene panel revealed the patient had a deletion of ELN exons 31-33.
Discussion:
The current understanding of ELN deletions and their corresponding phenotypes would suggest that deletions of exons 31-33 are associated with cutis laxa, aged appearance, and long philtrum. However, the patient of interest exhibited symptoms and physical exam findings that closely resembled hypermobile Ehlers-Danlos syndrome (hEDS). This case highlights the various potential causes of hypermobility and the limited understanding of the relationship between joint hypermobility and intragenic ELNgene mutations. The location of the patient’s ELN gene mutation, taken with the findings of the literature review, supports the hypothesis of a limited genotype-phenotype correlation in the ELN gene.
Towards Efficient Video-Based Action Recognition: Context-Aware Memory Attention Network
Authors: Koh Thean Chun , Yeo Chai Kiat , Jing Xuan 
Published: July 2023

Abstract
Human action recognition from videos has huge applications in daily life given the proliferation of surveillance cameras everywhere. The continuing challenge is to design more efficient models so that that they can approach real-time recognition and yet with good accuracy for ubiquitous deployment. In this paper, we propose a human action recognition model sans optical flow extraction and 3D convolution, called Context-Aware Memory Attention Network (CAMA-Net). The absence of optical flow extraction and 3D convolution makes CAMA-Net more efficient than many existing works. Key to CAMA-Net is an attention module called Context-Aware Memory Attention Module which is used to compute the relevance score between the key and value pairs from the 2D ResNet backbone thereby establishing the correspondences between the video frames. The proposed method is tested on four popular action recognition datasets, namely, UCF101, HMDB51, ActivityNet and Diving48. The experimental results demonstrate the strength of the proposed model as it outperforms existing baseline 2D CNN based models.
Ileoanal pouch revision and excision surgery in a newly established pouch center. Requirements and costs for service provision
Authors: Celentano Valerio , Lee Yu Jin , Rebelo David , Doulias Triantafyllos , Mills Sarah , Manzo Carlo Alberto 
Published: July 2023

Abstract
Background: Complications of ileoanal pouch surgery affecting function and quality of life may require surgical correction or pouch excision. The management of patients with pouch dysfunction requires a multidisciplinary approach and demand for service provisions include multiple healthcare professionals and resources. The aim of this study is to present the service requirements, surgical outcomes for redo pouch surgery and pouch excision, with cost-analysis of the required resources.
Methods: All patients undergoing surgery for revision or excision of the ileoanal pouch from June 2021 to May 2023 were prospectively included. Patient undergoing only diagnostic procedures, or perineal procedures were excluded. Outcomes within 30-days of surgery were collected, including readmissions and re-operations. Cost analysis of all investigations, outpatient appointments and procedures prior to pouch revision or pouch excision was conducted.
Results: Twenty patients were included during the 24 months study period: 13 underwent abdominal revisional pouch surgery, 7 had ileoanal pouch excision. 15 patients (75%) were tertiary referrals from other hospitals in the UK. The median interval between index IPAA surgery and revision was 113 months. 3 multidisciplinary clinical appointments, 2 imaging modalities, and at least one invasive day-surgery procedure were required for each patient prior to surgery. Four patients (20%) developed Clavien-Dindo 3 or higher complications.
Conclusions: We estimated a starting cost of £22.605 ($29.589) for provision of pouch revision or excision surgery for investigations and treatments from referral to the pouch unit to surgery. Expertise and infrastructure are needed for indication and peri-operative management of these uncommonly performed surgical procedures.