bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Knowledge and the Opacity Thesis in Kant’s Doctrine of Virtue
Authors: Halper Aaron 
Published: April 2023

AbstractKant’s moral philosophy both enjoins the acquisition of self-knowledge as a duty, and precludes certain forms of its acquisition via what has become known as the Opacity Thesis. This article looks at several recent attempts to solve this difficulty and argues that they are inadequate. I argue instead that the Opacity Thesis rules out only the knowledge that one has acted from genuine moral principles, but does not apply in cases of moral failure. The duty of moral self-knowledge applies therefore only to one’s awareness of one’s status as a moral being and to the knowledge of one’s moral failings, both in particular actions and one’s overall character failings, one’s vices. This kind of knowledge is morally salutary as an aid to discovering one’s individual moral weakness as well as the subjective ends for which one acts, and in this way for taking up the morally required end of treating human beings as human beings. In this way, moral self-knowledge can be understood as a necessary element of moral improvement, and I conclude by suggesting several ways to understand it thereby as genuinely primary among the duties to oneself.
The comparison of collapsed cone and Monte Carlo algorithms in tangential breast planning
Authors: Goss Matthew , Champ Colin , Trombetta Mark , Shamsesfandabadi Parisa , DeMartino Valerie , Wegner Rodney , Beriwal Sushil , Eisen Veronica 
Published: April 2023

Abstract

Introduction:
This study compared dose metrics between tangent breast plans calculated with the historical standard collapsed cone (CC) and the more accurate Monte Carlo (MC) algorithms. The intention was to correlate current plan quality metrics from the currently used CC algorithm with doses calculated using the more accurate MC algorithm.

Methods:
Thirteen clinically treated patients, whose plans had been calculated using the CC algorithm, were identified. These plans were copied and recalculated using the MC algorithm. Various dose metrics were compared for targets and the time necessary to perform each calculation. Special consideration was given to V105%, as this is increasingly being used as a predictor of skin toxicity and plan quality. Finally, both the CC and MC plans for 4 of the patients were delivered onto a dose measurement phantom used to analyse quality assurance (QA) pass rates. These pass rates, using various evaluation criteria, were also compared.

Results:
Metrics such as the PTVeval D95% and V95% showed a variation of 6% or less between the CC and MC plans, while the PTVeval V100% showed variation up to 20%. The PTVeval V105% showed a relative increase of up to 593% after being recalculated with MC. The time necessary to perform calculations was 76% longer on average for CC plans than for those recalculated using MC. On average, the QA pass rates using 2%2mm and 3%3mm gamma criteria for CC plans were lower (19·2% and 5·5%, respectively) than those recalculated using MC.

Conclusion:
Our study demonstrates MC-calculated PTVeval V105% values are significantly higher than those calculated using CC. PTVeval V105% is often used as a benchmark for acceptable plan quality and a predictor of acute toxicity. We have also shown that calculation times for MC are comparable to those for CC. Therefore, what is considered acceptable PTVeval V105% criteria should be redefined based on more accurate MC calculations.
“In the Name of the (God)Father”: Baptismal Naming in Early Colonial Guatemala
Authors: Matsumoto Mallory E. 
Published: April 2023

AbstractThis article examines baptismal naming in sixteenth-century Guatemala in the context of Indigenous adaptation to the sociopolitical upheavals of Spanish-led invasion, forced resettlement, and the imposition of Catholicism. As part of the institution of baptism—the first Catholic sacrament and one that missionaries implemented soon after their arrival in the Spanish Americas—Indigenous baptizees received a European name, as well as spiritual kin in the form of godparents. The distribution of baptismal names in late sixteenth- and early seventeenth-century Santiago Atitlán, a predominantly Tz'utujil Maya community in highland Guatemala, suggests that Indigenous christening marked a break with precolonial onomastic practice. Instead of continuing the Indigenous tradition of naming children according to their birthdate, Maya adults in the Santiago Atitlán area developed new naming strategies that simultaneously located their children in the Spanish administrative sphere and reconstituted local social networks in the wake of colonial disruptions. Furthermore, the influence of godparents on name selection both expressed and reinforced godparenthood's rising significance as the most socially salient Catholic institution in colonial Indigenous society and one that remains vibrant into the present.
A Confounded Statistic: Turn-of-the-Century Mexican Agriculture in Incommensurable Terms
Authors: Lurtz Casey Marina 
Published: April 2023

AbstractIn 1899, municipal officials throughout Mexico sent tables of agricultural statistics to Mexico City to assist in the preparation of a special publication for the 1900 Paris Universal Exposition, where the Mexican government hoped it would impress the world with Mexico's modernity and potential. Though the activity was nothing new, the ways in which municipal officials provided the requested information confounded the national project of both understanding and representing the Mexican countryside. The statistics were never published. This article serves as an introduction to a new dataset and collection of maps built from transcriptions of the manuscript tables. It also demonstrates that regular participation in statistical undertakings served as a means for provincial Mexicans to complicate and confound the process of state consolidation. Here I see, rather than refusal or rebellion, ready participation in state knowledge projects as another way in which those beyond Mexico City managed their relationships with President Porfirio Díaz's technocratic government. Engaging with conceptions of governmentality on one side and data management on the other, I use the 1899 agricultural statistics to highlight how unruly participation in data collection frustrated the practice's centralizing and standardizing project.
Discriminating Aromatic Parent Compounds and Their Derivative Isomers in Ice Grains From Enceladus and Europa Using a Laboratory Analogue for Spaceborne Mass Spectrometers
Authors: Khawaja N. , O’Sullivan T. R. , Klenner F. , Sanchez L. H. , Hillier J. 
Published: April 2023

AbstractResults from the Cassini‐Huygens space mission at Enceladus revealed a substantial inventory of organic species embedded in plume and E ring ice grains originating from a global subsurface and putative habitable ocean. Compositional analysis by the Cosmic Dust Analyzer indicated the presence of aromatic species and constrained some structural features, although their exact nature remains unclear. As indicated by many studies, among other organic species, low‐mass aromatics likely played a role in the emergence of life on Earth and may be linked to potential prebiotic or biogenic chemistry on icy moons. Here, we study the behavior of single‐ringed aromatic compounds—benzoic acid and two isomeric derivatives, 2,3‐dihydroxybenzoic acid and 2,5‐dihydroxybenzoic acid—using Laser‐Induced Liquid Beam Ion Desorption (LILBID), an analogue setup to simulate the impact ionization mass spectra of ice grains in space. These compounds share common structural features but also exhibit differences in functional groups and substituent positions. We investigate the fragmentation behavior and spectral appearance of each molecule over three simulated impact velocities, in both positive and negative ion modes. Parent compounds can be distinguished easily from their derivatives due to various spectral differences, including the (de)protonated molecular ion peaks appearing at different m/z values. We conclude that distinction between structural isomers in LILBID is more challenging, but some insights can be revealed by considering intermolecular bonding regimes. This work will guide future investigations into elucidating the composition of isomeric biosignatures in ice grains, relevant for future space missions to Enceladus and Europa.
Climatology of HF Propagation Characteristics at Very High Latitudes From SuperDARN Observations
Authors: Ponomarenko P. , McWilliams K. A. 
Published: April 2023

AbstractConventional forecasting of high‐frequency (HF, 3–30 MHz) radio wave propagation is based on a combination of ionospheric and propagation models. However, at very high latitudes this approach is seriously undermined by the intrinsically dynamic ionospheric conditions regularly perturbed by energetic particle precipitations and strong electric fields. From this perspective, the multi‐year observations of HF propagation characteristics by Super Dual Auroral Radar Network (SuperDARN) radars across auroral and polar cap regions represent a unique opportunity for systematic validation of the conventional approach, as well as for creating an empirical propagation model directly from the radar observations. Qualitative identification and quantitative characterization of the propagation modes requires an accurate knowledge of the vertical angle of arrival (elevation angle) across the high‐latitude part of the radar network. This information has become available only in recent years, facilitated by the development of reliable data‐based calibration techniques for SuperDARN interferometry. We present the solar‐cycle/seasonal/diurnal climatology of HF propagation characteristics at very high latitudes derived from two‐frequency observations by the Rankin Inlet SuperDARN radar.
Long-term humoral response following Delta and Omicron BA.1 co-infection
Authors: Saade Carla , Pozzetto Bruno , Yaugel-Novoa Melyssa , Oriol Guy , Josset Laurence , Lina Bruno , Paul Stéphane , Bal Antonin , Trouillet-Assant Sophie 
Published: April 2023

AbstractThis study reports the 6-month humoral immune response in vaccinated patients concomitantly infected with Delta and Omicron BA.1 variants of SARS-CoV-2. Interestingly, the simultaneous exposure to the Delta and BA.1 S proteins does not confer an additional immune advantage compared to exposure to the BA.1 S protein alone.
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex
Authors: Kišonaitė Miglė , Wild Klemens , Lapouge Karine , Gesé Genís Valentín , Kellner Nikola , Hurt Ed , Sinning Irmgard 
Published: April 2023

AbstractThe challenge of nascent chain folding at the ribosome is met by the conserved ribosome-associated complex (RAC), which forms a chaperone triad with the Hsp70 protein Ssb in fungi, and consists of the non-canonical Hsp70 Ssz1 and the J domain protein Zuotin (Zuo1). Here we determine cryo-EM structures of Chaetomium thermophilum RAC bound to 80S ribosomes. RAC adopts two distinct conformations accommodating continuous ribosomal rotation by a flexible lever arm. It is held together by a tight interaction between the Ssz1 substrate-binding domain and the Zuo1 N terminus, and additional contacts between the Ssz1 nucleotide-binding domain and Zuo1 J- and Zuo1 homology domains, which form a rigid unit. The Zuo1 HPD motif conserved in J-proteins is masked in a non-canonical interaction by the Ssz1 nucleotide-binding domain, and allows the positioning of Ssb for activation by Zuo1. Overall, we provide the basis for understanding how RAC cooperates with Ssb in a dynamic nascent chain interaction and protein folding.
Neutron tomography of sealed copper alloy animal coffins from ancient Egypt
Authors: O’Flynn Daniel , Fedrigo Anna , Perucchetti Laura , Masson-Berghoff Aurélia 
Published: April 2023

AbstractAnimal mummification was commonplace in ancient Egypt, with the remains of many animals placed inside statues or votive boxes with representations of animals or hybrid human–animal creatures. Votive boxes were made from a variety of materials and often sealed; some boxes are still preserved in this state in museum collections. A prior study of sealed copper alloy votive boxes from the collection of the British Museum used X-ray computed tomography to search for animal remains, where poor image quality resulted due to attenuation from the boxes and apparent dense metals inside. In this study, neutron tomography was applied to six of the votive boxes previously examined. Animal remains, likely from lizards, and fragments of textile wrappings were discovered inside three of the boxes. Evidence of the manufacturing process and subsequent repairs of the boxes were uncovered by neutrons. Significant quantities of lead were also identified in three boxes. The findings demonstrate the effectiveness of neutron tomography for the study of mummified remains inside sealed metal containers, and give evidence linking the animal figures represented on top of votive boxes to the concealed remains.
Aspergillus Carneus metabolite Averufanin induced cell cycle arrest and apoptotic cell death on cancer cell lines via inducing DNA damage
Authors: Demirel Deren , Ozkaya Ferhat Can , Ebrahim Weaam , Sokullu Emel , Sahin Irem Durmaz 
Published: April 2023

AbstractCancer is one of the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020. Current treatment methods include hormone therapy, γ-radiation, immunotherapy, and chemotherapy. Although chemotherapy is the most effective treatment, there are major obstacles posed by resistance mechanisms of cancer cells and side-effects of the drugs, thus the search for novel anti-cancer compounds, especially from natural sources, is crucial for cancer pharmaceutics research. One natural source worthy of investigation is fungal species. In this study, the cytotoxicity of 5 metabolic compounds isolated from filamentous fungus Aspergillus Carneus. Arugosin C, Averufin, Averufanin, Nidurifin and Versicolorin C were analyzed using NCI-SRB assay on 10 different cell lines of breast cancer, ovarian cancer, glioblastoma and non-tumorigenic cell lines. Averufanin showed highest cytotoxicity with lowest IC50 concentrations especially on breast cancer cells. Therefore, Averufanin was further investigated to enlighten cell death and molecular mechanisms of action involved. Cell cycle analysis showed increase in SubG1 phase suggesting apoptosis induction which was further confirmed by Annexin V and Caspase 3/7 Assays. H2A.X staining revealed accumulation of DNA damage in cells treated with Averufanin and finally western blot analysis validated DNA damage response and downstream effects of Averufanin treatment in various signaling pathways. Consequently, this study shows that Averufanin compound induces cell cycle arrest and cell death via apoptosis through causing DNA damage and can be contemplated and further explored as a new therapeutic strategy in breast cancer.
Uncertain future for global sea turtle populations in face of sea level rise
Authors: Rivas Marga L. , Rodríguez-Caballero Emilio , Esteban Nicole , Carpio Antonio J. , Barrera-Vilarmau Barbara , Fuentes Mariana M. P. B. , Robertson Katharine , Azanza Julia , León Yolanda , Ortega Zaida 
Published: April 2023

AbstractSea level rise has accelerated during recent decades, exceeding rates recorded during the previous two millennia, and as a result many coastal habitats and species around the globe are being impacted. This situation is expected to worsen due to anthropogenically induced climate change. However, the magnitude and relevance of expected increase in sea level rise (SLR) is uncertain for marine and terrestrial species that are reliant on coastal habitat for foraging, resting or breeding. To address this, we showcase the use of a low-cost approach to assess the impacts of SLR on sea turtles under various Intergovernmental Panel on Climate Change (IPCC) SLR scenarios on different sea turtle nesting rookeries worldwide. The study considers seven sea turtle rookeries with five nesting species, categorized from vulnerable to critically endangered including leatherback turtles (Dermochelys coriacea), loggerhead turtles (Caretta caretta), hawksbill turtles (Eretmochelys imbricata), olive ridley turtles (Lepidochelys olivacea) and green turtles (Chelonia mydas). Our approach combines freely available digital elevation models for continental and remote island beaches across different ocean basins with projections of field data and SLR. Our case study focuses on five of the seven living sea turtle species. Under moderate climate change scenarios, by 2050 it is predicted that at some sea turtle nesting habitats 100% will be flooded, and under an extreme scenario many sea turtle rookeries could vanish. Overall, nesting beaches with low slope and those species nesting at open beaches such as leatherback and loggerheads sea turtles might be the most vulnerable by future SLR scenarios.
A natural whitening alternative from upcycled food waste (acid whey) and underutilized grains (millet)
Authors: Nani Mercy , Krishnaswamy Kiruba 
Published: April 2023

AbstractThe dairy industry faces a daunting challenge in managing acid whey (AW), a byproduct of Greek yogurt manufacturing that is costly to dispose of and challenging to incorporate into other food products. However, recent studies have demonstrated that AW can be transformed into a viable white powder by encapsulating it in millet flour. Recently, concerns over the safety of the commonly used food-grade whitener titanium dioxide (TiO2) have arisen, and the search for an alternative food-whitening agent has become essential. This study evaluated the color attribute, proximate composition, sugar profile, amino acid profile, total phenolic content, antioxidant activity, and antinutrient content of the novel acid whey millet (AWM) powder. The L* values of the AWM powders were significantly higher than TiO2 and the rest of the millet formulations. The crude protein content in the AWM powders was significantly (p < 0.05) lower when compared to the crude protein content in millet flours. AWM powders had higher lactose levels and retained all major amino acids after spray drying. Macrominerals (P, K, Ca, and Na) and microminerals (Zn and Cu) significantly increased in the AWM powder, while tannin content was reduced in AWM powders. These findings suggest that AWM powder is a white powder that contains a wide range of components with high nutritional value that could be readily incorporated into various applications. In summary, this study provides a valuable contribution to the dairy industry by highlighting the potential of AWM powders as a natural alternative food whitening agent to TiO2.
Textural properties and adsorption behavior of Zn–Mg–Al layered double hydroxide upon crystal violet dye removal as a low cost, effective, and recyclable adsorbent
Authors: Abdel-Hady E. E. , Mohamed Hamdy F. M. , Hafez Sarah H. M. , Fahmy Abdalla M. M. , Magdy Abdelhamed , Mohamed Aya S. , Ali Eman O. , Abdelhamed Hager R. , Mahmoud Osama M. 
Published: April 2023

AbstractThe preparation of adsorbents plays a vital role in the adsorption method. In particular, many adsorbents with high specific surface areas and unique shapes are essential for the adsorption strategy. A Zn–Mg–Al/layer double hydroxide (LDH) was designed in this study using a simple co-precipitation process. Adsorbent based on Zn–Mg–Al/LDH was used to remove crystal violet (CV) from the wastewater. The impacts of the initial dye concentration, pH, and temperature on CV adsorption performance were systematically examined. The adsorbents were analyzed both before and after adsorption using FTIR, XRD, and SEM. The roughness parameters and surface morphologies of the produced LDH were estimated using 3D SEM images. Under the best conditions (dose of adsorbent = 0.07 g and pH = 9), the maximum adsorption capacity has been achieved. Adsorption kinetics studies revealed that the reaction that led to the adsorption of CV dye onto Zn–Mg–Al/LDH was a pseudo-second-order model. Additionally, intraparticle diffusion suggests that Zn–Mg–Al/LDH has a fast diffusion constant for CV molecules (0.251 mg/(g min1/2)). Furthermore, as predicted by the Langmuir model, the maximal Zn–Mg–Al/LDH adsorption capacity of CV was 64.80 mg/g. The CV dimensionless separation factor (RL) onto Zn–Mg–Al/LDH was 0.769, indicating that adsorption was favorable. The effect of temperature was performed at 25, 35, and 45 °C in order to establish the thermodynamic parameters ∆Ho, ∆So, and ∆Go. The computed values indicated exothermic and spontaneous adsorption processes. The study presented here might be used to develop new adsorbents with enhanced adsorption capabilities for the purpose of protecting the water environment.
Acute balenine supplementation in humans as a natural carnosinase-resistant alternative to carnosine
Authors: de Jager Sarah , Vermeulen An , De Baere Siegrid , Van der Stede Thibaux , Lievens Eline , Croubels Siska , Jäger Ralf , Purpura Martin , Bourgois Jan G. , Derave Wim 
Published: April 2023

AbstractBalenine possesses some of carnosine’s and anserine’s functions, yet it appears more resistant to the hydrolysing CN1 enzyme. The aim of this study was to elucidate the stability of balenine in the systemic circulation and its bioavailability in humans following acute supplementation. Two experiments were conducted in which (in vitro) carnosine, anserine and balenine were added to plasma to compare degradation profiles and (in vivo) three increasing doses (1–4–10 mg/kg) of balenine were acutely administered to 6 human volunteers. Half-life of balenine (34.9 ± 14.6 min) was respectively 29.1 and 16.3 times longer than that of carnosine (1.20 ± 0.36 min, p = 0.0044) and anserine (2.14 ± 0.58 min, p = 0.0044). In vivo, 10 mg/kg of balenine elicited a peak plasma concentration (Cmax) of 28 µM, which was 4 and 18 times higher than with 4 (p = 0.0034) and 1 mg/kg (p = 0.0017), respectively. CN1 activity showed strong negative correlations with half-life (ρ = − 0.829; p = 0.0583), Cmax (r = − 0.938; p = 0.0372) and incremental area under the curve (r = − 0.825; p = 0.0433). Overall, balenine seems more resistant to CN1 hydrolysis resulting in better in vivo bioavailability, yet its degradation remains dependent on enzyme activity. Although a similar functionality as carnosine and anserine remains to be demonstrated, opportunities arise for balenine as nutraceutical or ergogenic aid.
Exclusive breastfeeding at 6 months after assisted and spontaneous conceiving: a prospective study in Northern Italy
Authors: Pisoni Camilla , Garofoli Francesca , De Silvestri Annalisa , Civardi Elisa , Ghirardello Stefano 
Published: April 2023

AbstractConceiving by assisted infertility treatments may influence breastfeeding duration. In one-year time, to evaluate the goal of 6 months breastfeeding, we recruited 55 consecutive mothers who conceived using assisted treatment compared to 45 mothers conceiving naturally, all giving birth to healthy, full-term, singleton infants, sharing the double-occupancy room. At birth, maternal/neonatal characteristics were obtained by medical records and interviews. Six months after, a telephonic interview was done about the exclusivity of breastfeeding, mood instability, and breastfeeding complications. All the women were supported by the same neonatal-pediatrician team, during the study period. The number of mothers who were exclusively breastfeeding at six months was not statistically different between the two groups, as well as, breastfeeding initiation, BMI, smoking habit, mood instability, co-morbidities. In the assisted group, the women were older, had fewer previous children, upper degree of education, higher rate of cesarean sections, their neonate’s birthweight was lower; they reported more breastfeeding complications, but the distribution was not different between groups. The control women had higher number of previously breastfed siblings. Our experience highlights that the mode of conception may not be the defining factor influencing the goal of 6 months lactation. The support of healthcare professional team has a crucial role in maintaining breastfeeding.