bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel highly selective allosteric inhibitor of TYK2 can block inflammation/autoimmune pathways
Authors: Chen Celia X-J , Zhang Wei , Xia Fucan , Qu Shulan , Chen Bo 
Published: June 2023

Abstract
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which plays an important part in signal transduction and regulation of the immune system. To minimize the safety concerns and improve the therapeutic effect against autoimmune diseases, we developed a small molecule inhibitor (QL-1200186) targeting the pseudokinase domain of TYK2 protein (JH2). The binding sites of QL-1200186 were predicted and screened by molecular docking. The inhibitory effects of the downstream signaling pathways and transcriptional activators of TYK2 were reflected in cell lines and human peripheral-blood cells. Pharmacokinetics and pharmacodynamics were verified in mice. QL-1200186 showed highly affinity to TYK2 JH2 and had no apparent selectivity for the TYK2 and JAK homologous kinase domains (JH1); these effects were manifested in assays based on biochemical binding, signaling pathway transduction (JAK1/2/3) and off-target effects. We revealed that currently available drugs, such as BMS-986165 and NDI-034858, were the most likely candidates for TYK2 inhibitors, and found that QL-1200186 was functionally comparable to and selectively superior to both agents in vitro. QL-1200186 showed excellent exposure, high bioavailability and afforded low clearance rates in mice. Oral administration of QL-1200186 dose-dependently inhibited interferon-γ production in interleukin-12-driven responses and ameliorated skin lesions significantly in a mouse model of psoriasis, respectively. These findings suggest that QL-1200186 is a highly selective and potent inhibitor of TYK2. QL-1200186 could be developed as a drug for the treatment of psoriasis or other autoimmune diseases.
Spatiotemporal evolution trend and decoupling type identification of transport carbon emissions from economic development in China
Authors: Cui Qian , Zhou Zhi Xiang , Guan Dongjie , Zhou Lilei , Huang Ke , Xue Yuqian 
Published: June 2023

Abstract
Carbon emissions are a major concern in China, and transportation is an important part of it. In this paper, data on China's 30 provinces' transport carbon emissions from 2005 to 2020 were selected to construct a spatial autocorrelation model and identified the decoupling type, which revealed the relationship between transport carbon emissions and economic development. This study suggests a regulation strategy for provincial transport carbon emissions in China based on the contribution rates of transport carbon emission variables. According to the findings, transport carbon emissions of China indicated a slow rise from 2005 to 2020, the annual growth rate has fluctuated downward, and the use of petroleum products has been the most major source. The geographical correlation of transport carbon emissions has gradually improved, and the transport carbon emission intensity has become more significant. Differences of the transport carbon emission intensity slightly increased, that were significantly regionally correlated. There were seven forms of decoupling between yearly provincial transport carbon emissions and economic development, with weak decoupling accounting for the largest proportion, 42.89%. Decoupling was achieved in 90% of the provinces in 3 five-year periods from 2006-2020. As a consequence of factor decomposition, the energy intensity, transport intensity, and economic structure played an overall inhibitory role, while the carbon emission intensity, economic scale and population played promoting roles. Economic scale was the most important spatial influencing factor.
Effect of particle size on the biomethanation kinetics of mechanically pretreated Sargassum spp biomass
Authors: Paletta Rosy , Girimonte Rossella , Castro Yessica A. , de Frias J. Atilio , Calabrò Vincenza 
Published: June 2023

Abstract
Purpose
The collection and use of Sargassum spp. as feedstock for the production of valuable products such as biomethane by anaerobic digestion (AD) would mitigate the negative impact of the blooms and the costs related to waste management in the Dominical Republic.
Methods
In this work, the effect of the particle size of pelagic Sargassum spp. biomass, as a result of mechanical pretreatments, on the biomethanation was determined. The Biochemical Methane Potential (BMP) of the samples was determined using an Automatic Potential System Test II (AMPTS® II). The kinetic parameters of the reaction were scientifically evaluated by using First order kinetic Model and modified Gompertz Model.
Results
We observed that BMP increased by 78.85% when particles were reduced from 50000 µm to 505 µm and by 73.61% when particles were reduced from 50000 µm to 107 µm.
Conclusion
A low methane yield from biomass S.3 compared to S.2 could be related to the excessive reduction of particle size. The fine particles are subject to the formation of aggregates and consequently, the contact area between the algae cells and the microorganisms that operate the anaerobic digestion process decreases.
Energy absorption of 2D auxetic structures fabricated by fused deposition modeling
Authors: Tunay Merve , Cetin Erhan 
Published: June 2023

Abstract
Auxetic structures exhibiting unusual mechanical properties from conventional materials are used in many industries and applications due to their high strength, energy absorption performance, high deformation resistance, impact resistance and flexibility. In order to further improve their mechanical properties, it is very important to investigate the deformation behavior and energy absorption characteristics of auxetic structures with different design parameters. In this context, the energy absorption performance of re-entrant auxetic structures with different design parameters i.e., strut orientation, strut angle, and strut thickness was investigated under axial loading in this study. The auxetic structures were produced by the fused deposition modeling method and the energy absorption performances of the structures were evaluated using various crashworthiness indicators such as energy absorption (EA), specific energy absorption (SEA), mean crash force (MCF), peak crash force (PCF) and crash force efficiency (CFE). Analysis of variance (ANOVA) was also implemented to determine the influence of design parameters on MCF, SEA and CFE. The results showed that the strut thickness is the highest influencing parameter on the values for all chosen energy absorption criteria. In particular, the contribution ratios of strut thickness, strut angle and strut orientation on the values of SEA are74.99%, 11.45% and 3.25%, respectively. These values are 63.74%, 7.22% and 0.92% for CFE values, respectively.
Investigation of the mechanical response of laminated composites reinforced with different type wire mesh
Authors: Alev Kubranur Isgor , KAMAN Mete Onur , ALBAYRAK Mustafa , Yanen Cenk 
Published: June 2023

Abstract
In this study, the mechanical behavior of laminated glass fiber composite plates reinforced with wire meshes under in-plane and out-of-plane loads was investigated. For this purpose, composite plates were produced by vacuum infusion method by placing aluminum and glass fiber wire layers with different mesh numbers between woven glass fiber fabrics. Afterward, impact and tensile tests were applied to the obtained specimens, respectively. The effect of the added reinforcement wires meshes on the impact resistance and tensile strength of the composites was determined. According to the data obtained; When glass wire with the same mesh number is used, 19.2% more reaction force was obtained than aluminum wire. The results of the double cantilever beam (DCB) and end notched flexure (ENF) test results confirmed that glass wire meshes had a better adhesion surface compared to aluminum. In addition, critical energy release rates were obtained with the help of the ANSYS finite element program and the data were compared with the experimental results. In the case of increasing the mesh number, it was observed that the reaction force of the glass wire mesh reinforced composite decreased by 17.54% under the impact. It was determined by scanning electron microscope (SEM) images that this decrease in the reaction force occurred due to the matrix material contacting the interlayer adhesion surfaces to a lesser extent. One layer of wire mesh reinforcement had no significant effect on the tensile strength of the glass fiber composite.
Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trail and preliminary baseline data
Authors: Lantis Kristen D , Schnell Patrick , Bland Courtney R. , Wilder Jacqueline , Hock Karen , Glover Nelson A. , Hackney Madeleine E. , Lustberg Maryam B. , Worthen-Chaudhari Lise 
Published: June 2023

Abstract
Background
Breast cancer (BC) is among the most common forms of cancer experienced by women. Up to 80% of BC survivors treated with chemotherapy experience chemotherapy-induced neuropathy (CIN), which degrades motor control, sensory function, and quality of life. CIN symptoms include numbness, tingling, and/or burning sensations in the extremities; deficits in neuromotor control; and increased fall risk. Physical activity (PA) and music-based medicine (MBM) are promising avenues to address sensorimotor symptoms. Therefore, we propose that we can combine the effects of music- and PA-based medicine through Neurologic Dance Training (NDT) through partnered Adapted Tango (NDT-Tango). We will assess the intervention effect of NDT-Tango v. home exercise (HEX) intervention on biomechanically-measured variables. We hypothesize that 8 weeks of NDT-Tango practice will improve the dynamics of posture and gait more than 8 weeks of HEX.
Methods
In a single-center, prospective, two-arm randomized controlled clinical trial, participants are randomly assigned (1:1 ratio) to the NDT-Tango experimental or the HEX active control intervention group. Primary endpoints are change from baseline to after intervention in posture and gait. Outcomes are collected at baseline, midpoint, post, 1mo follow up, and 6mo follow up. Secondary and tertiary outcomes include clinical and biomechanical tests of function and questionnaires used to compliment primary outcome measures. Linear mixed models will be used to model changes in postural, biomechanical, and PROs. The primary estimand will be the contrast representing the difference in mean change in outcome measure from baseline to week 8 between treatment groups.
Discussion
The scientific premise of this study is that NDT-Tango stands to achieve more gains than PA practice alone through combining PA with MBM and social engagement. Our findings may lead to a safe non-pharmacologic intervention that improves CIN-related deficits.
Trial Registration
This trial was first posted on 11/09/21 at ClinicalTrials.gov under the identifier NCT05114005.
Formulation and evaluation of novel nutraceuticals rich in protein, vitamins, minerals, natural flavors, and steviol glycosides for improving quality of life
Authors: Almoselhy Rania I.M. 
Published: June 2023

Abstract
For a wide range of people, including malnourished adults with non-communicable diseases (NCDs), micronutrient deficiency, underweight and overweight people, pregnant and lactating women, and adolescents, the current research aimed to present novel nutraceuticals devoted to improving the quality of life (QoL) with evidence-based health benefits, with daily values (DVs) according to the Food and Drug Administration (FDA), containing high-quality whey protein concentrate (WPC 70%), skim milk powder (SMP 34%), vitamins (folic acid, B12, C), minerals (iron, zinc), natural flavors (vanilla, cinnamon, coffee, chocolate), and stevia leaves extract (zero-calorie sweetener). The novel nutraceutical formulations were subjected to the physicochemical, microbiological, and sensory evaluation. The results showed significant differences (P<0.05) among formulations with natural flavors added in different amounts in order to provide 10 g of protein (20% DV), elemental iron and zinc, vitamin C, folic acid, and vitamin B12 (25% DV), with elemental calcium (20% DV) emerged from milk derivatives. The serving sizes of the four formulas were different according to the difference in the amount of natural flavor while keeping the same amounts of the other ingredients. Following the chocolate-flavored formulation as the first in order of overall acceptability, were coffee, cinnamon, and vanilla-flavored formulation, according to the sensory evaluation.
Intrapulmonary Lymph Nodes Positive for Metastases, in a Typical Multifocal Neuroendocrine Tumor: a Case Report
Authors: Gaviria Habib Jussef Mantilla , Ruiz Willfredy Castaño 
Published: June 2023

Abstract
Background
Multifocal neuroendocrine tumors of the lung are rare, usually having low nodal involvement in early stages. We bring to the literature a case of a typical multifocal carcinoid associated to tumors with intrapulmonary lymph node (IPLN) involvement.
Case presentation:
59-year-old female asymptomatic patient with multiple nodules in the right lower lobe, PET-CT with hypermetabolic nodule, adequate pulmonary function, for which a right lower lobectomy was performed plus intrapulmonary lymph nodes dissection in the fresh surgical specimen. The lymph nodes of stations 11, 12, 13 and 14 were sent to pathology. The pathology laboratory report showed that stations 10, 11, 12 and 13 were negative, but station 14 was positive. Thus, changing the stage from Ia2 to IIb.
Conclusion
This patient had an upstaging because of IPLN were positive for metastasis. The search for a more accurate oncologic staging through intrapulmonary lymph node may allow a more accurate staging and therefore a better treatment for the patient regardless type histology.
Screening COVID-19 by Swaasa AI Platform using cough sounds: A cross- sectional study
Authors: Pentakota Padmalatha , Rudraraju Gowrisree , Srip Narayana Rao , Mamidgi Baswaraj , Gottipulla Charishma , Jalukuru Charan , Palreddy Shubha Deepti , Bhoge Nikhil kumar Reddy , Firmal Priyanka , Yechuri Venkat , Jain Manmohan , Peddireddi Venkata Sudhakar , Bhimarasetty Devi Madhavi , S Sreenivas , K Kesava Lakshmi Prasad , Joshi Niranjan , Vijayan Shibu , Tugara Sanchit , Avasarala Vardhan 
Published: June 2023

Abstract
The Advent of Artificial Intelligence (AI) has led to the use of auditory data for detecting various diseases, including COVID-19. SARS-CoV-2 infection has claimed more than six million lives to date and therefore, needs a robust screening technique to control the disease spread. In the present study we created and validated the Swaasa AI platform, which uses the signature cough sound and symptoms presented by patients to screen and prioritize COVID-19 patients. We collected cough data from 234 COVID-19 suspects to validate our Convolutional Neural Network (CNN) architecture and Feedforward Artificial Neural Network (FFANN) (tabular features) based algorithm. The final output from both models was combined to predict the likelihood of having the disease. During the clinical validation phase, our model showed a 75.54% accuracy rate in detecting the likely presence of COVID-19, with 95.45% sensitivity and 73.46% specificity. We conducted pilot testing on 183 presumptive COVID subjects, of which 58 were truly COVID-19 positive, resulting in a Positive Predictive Value of 70.73%. Due to the high cost and technical expertise required for currently available rapid screening methods, there is a need for a cost-effective and remote monitoring tool that can serve as a preliminary screening method for potential COVID-19 subjects. Therefore, Swaasa would be highly beneficial in detecting the disease and could have a significant impact in reducing its spread.
Influence of Environmental Parameters on Workers’ Dust Inhalation in Underground Mines
Authors: Huang Rongting , Chen Wanyi , Tao Yichun , Yuan Shilong , Geng Fan , Li Shihang 
Published: June 2023

Abstract
Much dust is generated in coal mining underground work processes, posing threats to workers’ health and safety production. Dust enters the human body mainly through inhalation, which is primarily determined by the dust concentration around workers. In this study, the airflow field and dust distribution in the tunnel are simulated by Fluent software. The breathing zone for a worker was defined to clarify the extent of external dust distribution influencing dust inhalation. The effects of human respiration, dust production rates, air supply velocities, and workers’ positions on dust concentration in the breathing zone were investigated. The results show that there is upward airflow around the worker standing in the center of the air circulation. Human inhalation and exhalation barely influence the airflow distribution and respirable dust concentrations in the breathing zone. Reducing the dust production rate in the tunnel can reduce the respirable dust concentration in the breathing zone by almost the same proportion. While increasing the air supply velocity by 50% would reduce only 20% dust in the breathing zone. The dust concentrations vary along the roadway, in which the low concentration zone is located in the middle, more than 1.0 m away from the dust-producing surface and the wind surface.
Characteristics performance and analysis of positional variation in charge generation layer to enhance performance of OLED.
Authors: Yadav Sugandha , Mittal Poornima , Negi Shubham 
Published: June 2023

Abstract
In this paper, a highly efficient charge generation layer (CGL) based blue organic light emitting diode (OLED) is proposed. The proposed device contains a CGL which comprises of two materials 1,1-bis[(di-4-tolyamino)phenyl)]cyclohexane (TAPC) and 1,4,5,8,9,11-hexaazatriphenylene-hexacarbonitrile (HAT-CN) which act as hole and electron injectors, correspondingly. The CGL in the proposed device is placed outside of the emissive layer which provides better luminescence and current as compared with four other CGL based devices D2, D3, D4 and D5 where CGL is utilized below cathode, above anode, near both electrodes (cathode and anode) and inside the emissive layer, respectively. The proposed device exhibits noteworthy results as peak values of current and luminescence are achieved as 0.44 A and 3636.3 cd/m2, correspondingly. The obtained luminescence is about 16.8, 2.3, 1.7, 3, 1.6 times improved on comparing with D1, D2, D3, D4 and D5. Furthermore, thickness optimization of the proposed device is also outlined. The optimized device showed the maximum luminescence of 4670 cd/m2.
Melittin as a safe compound to BALB/c mice immune system; A tiered approach immunotoxicity screening
Authors: Karimi Gholamreza , Fatemi Sina , Memar Bahram , Khorrami Mohammad-Bagher , Amali Arian , Sadeghi Mahmood , Esmaeili Seyed-Alireza , Riahi-Zanjani Bamdad 
Published: June 2023

Abstract
Background: Maintenance of a well-functioning immune system is a vital requirement to protect human body against pathogens/cancers. Natural compounds have long been used because of their benefits for the immune system. One of which is bee venom that contains a peptide called melittin having antimicrobial and anticancer effects. Since a limited number of studies regarding the effects of melittin on the immune system have been carried out, we aimed to evaluate the effects of melittin on BALB/c mice immune system parameters.
Methods: Female BALB /c mice were treated intraperitoneally (i.p) with 0.75 and 1.5 mg/kg doses of melittin for 14 days (5 doses per week). The negative control group received i.p normal saline whereas the positive control group received i.p 20 mg/kg cyclophosphamide (CYP). Immunological parameters such as hematological parameters, delayed-type hypersensitivity (DTH), hemagglutination titer (HA), spleen cellularity, splenocytes proliferation, as well as spleen and bone marrow histopathological assessment were evaluated.
Results: Our findings showed that melittin has no gross pathological effect on the spleen and bone marrow. It was also demonstrated that melittin has no any significant effect on hematological parameters. Melittin did not cause any significant changes to proliferation response of splenocytes to PHA and LPS, spleen cellularity, DTH response, as well as the production of anti-SRBC antibodies. The results showed that melittin at 0.75 and 1.5 mg/kg doses could not induce significant changes on immune parameters. Based on our results, melittin was found to be safe for the mice immune system.
Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: Study protocol of a randomized trial
Authors: Bock Patrícia Martins , Kowalewski Lucas Stahlhöfer , Ayres Layane Ramos , Russo Mariana Kras Borges , Dornelles Laura Ilha , Leites Gabriela Tomedi , Martins Andreza Francisco , Oliveira Álvaro Reischak , Krause Mauricio 
Published: June 2023

Abstract
Background: Heat shock response (HSR) is blocked in diabetes, but can be partially restored by resistance training. Some people have difficulties in performing physical exercise, therefore, an alternative therapy is heat therapy (HT). Interventions capable of modulating HSR, such as physical exercise and heat therapy, are candidates as therapeutic strategies combined in the prevention and treatment of diabetes. This study aims to evaluate the effect of resistance training (RT) and HT in type 2 diabetes mellitus (T2DM) on HbA1c levels, metabolic and inflammatory profile, gut microbiota, and HSR.
Methods: A randomized, double-blind, parallel clinical trial will be conducted for 12 weeks. Participants with T2DM will be randomized into intervention groups Control (C), RT or HT. In the control group, participants will not receive any intervention. In the intervention group RT, participants will perform supervised exercise (~60 min) on three non-consecutive days of the week. Participants in the HT group will undertake whole body heat treatment in an environmental chamber initially set at 55.0oC on three non-consecutive days of the week (60 min). Blood samples will be collected before and after 12 weeks of treatment, to evaluate heat shock response, body composition and physical fitness, glycemic control, lipid profile, gut microbiota composition and diversity, inflammatory markers and flow mediated dilation.
Discussion: Since HSR response is decreased in individuals with diabetes, we believe that improving HSR may be important to prevent chronic complications associated with T2DM. This randomized clinical trial will determine the efficacy of HT compared to RT for improving HR when added to conventional therapy in individuals with T2DM. The multiple HT and RT effects might contribute to lower mortality risk in these individuals. Our study is the first to evaluate the efficacy of HT and RT, for 12 weeks, in glucose, lipid and inflammatory profile, microbiota, and HR in individuals with T2DM. Moreover, we will maintain the experimental protocol for 12 weeks, which is the time necessary to obtain changes in the main parameter of diabetes control, HbA1c.
Trial registration: NCT05847075. Registered on ClinicalTrials.gov, 05/06/23.