bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work or Alienation? A Conceptual Understanding of Academic Labour Process in Neo-liberal University System
Authors: Oladeinde Olusegun 
Published: July 2023

In recent years, universities in Nigeria, and indeed elsewhere, have continued to face challenges on how to deliver more quality services to the stakeholders; both within and outside the University’s communities. These challenges have had to do with the ways in which Universities are funded and managed which consequently have implications on how the Universities organise and control academic work i.e. teaching, administration and research. These main responsibilities for academic staff in the Universities are conceptualised as academic labour process. Within a more generic understanding of Higher Education’s (HE) Management, Universities are therefore expected to device more efficient means of managing, and organising academic work process. In this context, “quality” has come to convey improved processes which define the performance of Universities. However, these are not without implications on leadership roles, work experiences, quality of work-life balance, and employability of the academics. The Paper provides a conceptual review and theoretical understanding of academic labour process in the universities. It evaluates the normative assumptions, and the implications of academic labour process on the lived-work experience of academics.
Heterogeneous Doping via Methyl‐Encapsulated Fumed Silica Enabling Weak Solvated and Self‐Purified Electrolyte in Long‐Term High‐Voltage Lithium Batteries
Authors: Zhou Jinwei , Wu Siyao , Chu Fulu , Jiang Ziang , Wu Feixiang 
Published: January 2025

AbstractCrafting a sustainable non‐aqueous electrolyte is paramount in the pursuit of high‐voltage lithium batteries that exhibit exceptional performance. Traditional carbonate‐based electrolytes encounter hurdles in maintaining electrochemical stability due to unstable interphases, as well as continuous degradation of the electrolyte itself. Herein, based on heterogeneous doping, a colloidal electrolyte with multiple functions via simple integrating methyl‐encapsulated fumed silica (MFS) into a conventional carbonate‐based electrolyte effectively addresses the aforementioned challenges. The produced colloidal electrolyte endowed with unexpected self‐purification capabilities effectively eliminates HF and H2O, consequently enhancing stability of the electrolyte, interphase, and electrode. Furthermore, MFS induces a weakly solvated Li+ structure that is heterogeneously doped into the original solvation matrix and contributes to the formation of tailored and stable electrode/electrolyte interphases for both anode and cathode. Using such electrolyte, Li||LiCoO2 batteries demonstrate capacity retentions of 83.6% and 95.4% within 3000 and 1000 cycles at charging voltages of 4.4 and 4.5 V, respectively. Remarkably, with addition of 2000 ppm H2O in this electrolyte, cells can be cycled stably over 400 cycles with a capacity retention of 88.6%. This simple and effective electrolyte engineering strategy has the sustainability to significantly advance the development of highly stable high‐voltage lithium batteries.
Intratumoral Collagen Deposition Supports Angiogenesis Suggesting Anti‐angiogenic Therapy in Armored and Cold Tumors
Authors: Mei Jie , Yang Kai , Zhang Xinkang , Luo Zhiwen , Tian Min , Fan Hanfang , Chu Jiahui , Zhang Yan , Ding Junli , Xu Junying , Cai Yun , Yin Yongmei 
Published: January 2025

AbstractA previous study classifies solid tumors based on collagen deposition and immune infiltration abundance, identifying a refractory subtype termed armored & cold tumors, characterized by elevated collagen deposition and diminished immune infiltration. Beyond its impact on immune infiltration, collagen deposition also influences tumor angiogenesis. This study systematically analyzes the association between immuno‐collagenic subtypes and angiogenesis across diverse cancer types. As a result, armored & cold tumors exhibit the highest angiogenic activity in lung adenocarcinoma (LUAD). Single‐cell and spatial transcriptomics reveal close interactions and spatial co‐localization of fibroblasts and endothelial cells. In vitro experiments demonstrate that collagen stimulates tumor cells to express vascular endothelial growth factor A (VEGFA) and directly enhances vessel formation and endothelial cell proliferation through sex determining region Y box 18 (SOX18) upregulation. Collagen inhibition via multiple approaches effectively suppresses tumor angiogenesis in vivo. In addition, armored & cold tumors display superior responsiveness to anti‐angiogenic therapy in advanced LUAD cohorts. Post‐immunotherapy resistance, the transformation into armored & cold tumors emerges as a potential biomarker for selecting anti‐angiogenic therapy. In summary, collagen deposition is shown to drive angiogenesis across various cancers, providing a novel and actionable framework to refine therapeutic strategies combining chemotherapy with anti‐angiogenic treatments.
Multivariate Approaches Boosting Lithium‐Mediated Ammonia Electrosynthesis in Different Electrolytes
Authors: Mangini Anna , Mygind Jon Bjarke Valbæk , Ballesteros Sara Garcia , Pedico Alessandro , Armandi Marco , Chorkendorff Ib , Bella Federico 
Published: January 2025

AbstractAmmonia electrosynthesis through the lithium‐mediated approach has recently reached promising results towards high activity and selectivity in aprotic media, reaching high Faradaic efficiency (FE) values and NH3 production rates. To fasten the comprehension and optimization of the complex lithium‐mediated nitrogen reduction system, for the first time a multivariate approach is proposed as a powerful tool to reduce the number of experiments in comparison with the classical one‐factor‐at‐a‐time approach. Doehlert design and surface response methodology are employed to optimize the electrolyte composition for a batch autoclaved cell. The method is validated with the common LiBF4 salt, and the correlations between the FE and the amount of lithium salt and ethanol as proton donor are elucidated, also discussing their impact on the solid electrolyte interphase (SEI) layer. Moreover, a new fluorinated salt is proposed (i.e., lithium difluoro(oxalate) borate (LiFOB)), taking inspiration from lithium batteries. This salt is chosen to tailor the SEI layer, with the aim of obtaining a bifunctional interfacial layer, both stable and permeable to N2, the latter being an essential characteristic for batch systems. The SEI layer composition is confirmed strategic and its tailoring with LiFOB boosts FE values.
Revealing the CO Tolerance Mechanism in Acidic Hydrogen Oxidation Reactions on Platinum‐Based Catalyst Surfaces
Authors: Chen Zi‐Han , Chen Xing , Kang Wei , Zheng Shisheng , He Quan‐Feng , Li Qiong‐Qiong , Zhang Yu‐Xing , Hou Yu‐Cheng , Tian Jing‐Hua , Dong Jin‐Chao , Li Jian‐Feng 
Published: January 2025

AbstractThe presence of trace CO impurity gas in hydrogen fuel can rapidly deactivate platinum‐based hydrogen oxidation reaction (HOR) catalysts due to poisoning effects, yet the precise CO tolerance mechanism remains debated. Our designed Au@PtX bifunctional core–shell nanocatalysts exhibit excellent performance of CO tolerance in acidic solution during HOR and possess exceptional Raman spectroscopy enhancement. Through capturing and analyzing in situ Raman spectroscopy evidences on *OH, metal‐O species and *CO evolution under 0.3 V, we confirm that oxygen‐containing species on PtRu and PtSn catalysts promote the oxidation and desorption of *CO. While Ru enhances *CO adsorption on Pt, the primary CO tolerance performance of PtRu arises from *CO oxidation via a bifunctional pathway. Additionally, electronic structure of Sn reduces *CO adsorption on Pt sites, complementing the bifunctional mechanism to further enhance the CO tolerance performance of PtSn. These discoveries significantly deepen our understanding of the anti‐poisoning mechanism of Pt‐based catalysts in the HOR process and offer valuable insights for rational catalyst design.
Ultrafast Water Purification by Template‐Free Nanoconfined Catalysts Derived from Municipal Sludge
Authors: Gu Chao‐Hai , Du Meng , Han Ru‐Yi , Zhang Ai‐Yong , Yu Han‐Qing , Xing Mingyang 
Published: January 2025

AbstractNanoconfinement at the interface of heterogeneous Fenton‐like catalysts offers promising avenues for advancing oxidation processes in water purification. Herein, we introduce a template‐free strategy for synthesizing nanoconfined catalysts from municipal sludge (S‐NCCs), specifically engineered to optimize reactive oxygen species (ROS) generation and utilization for rapid pollutant degradation. Using selective hydrofluoric acid corrosion, we create an architecture that confines atomically dispersed Fe centers within a micro‐mesoporous carbon matrix in situ. This method maximizes the utilization of silicon and aluminum content from sludge, prevents metal agglomeration, and precisely regulates the chemical environment of Fe active sites. As a result, the S‐NCCs promote a transition from nonradical to hybrid radical/nonradical reaction mechanisms, significantly enhancing ROS efficiency, stability, and pollutant degradation rates. These catalysts demonstrate exceptional pollutant removal performance, achieving a 261‐fold increase in degradation efficiency for compounds such as phenol and sulfamethoxazole compared to unconfined analogs, outperforming most state‐of‐the‐art Fenton‐like systems. Our findings highlight the transformative potential of nanoconfined catalysis in environmental applications, providing an effective and scalable solution for sustainable water purification.
Boosting C‐O Bond Cleavage and Reverse Water‐Gas Shift Activity via Enriched In‐Plane Sulfur Vacancies in Single‐Layer Molybdenum Disulfide
Authors: Zheng Zhiyuan , Shang Xin , Wang Weijue , Yang Xiaofeng , Su Xiong , Huang Yanqiang 
Published: January 2025

AbstractThe reduction of CO2 to CO provides a promising approach to the production of valuable chemicals through CO2 utilization. However, challenges persist with the rapid deactivation and insufficient activity of catalysts. Herein, we developed a soft‐hard dual‐template method to synthesize layered MoS2 using inexpensive and scalable templates, enabling facile regulation of sulfur vacancies by controlling the number of layers. The concentration of in‐plane vacancies keeps increasing with the reduction of MoS2 layer number, contributing to 100 % CO selectivity over single‐layer MoS2 and a stable performance over 300‐hour reaction at 600 °C. The space‐time‐yield of CO reached 35.7 gCO gcat−1 h−1, outperforming most current catalysts. Multiple characterizations and theoretical calculations revealed that in‐plane sulfur vacancy sites endowed enhanced production of CO via direct dissociation of CO2, showing an intrinsic activity of above 5.8 times higher than that of edge sulfur vacancy sites. The rate‐limiting step was shifted from C−O cleavage in edge to sulfur vacancy regeneration in plane with a lower energy barrier. Our findings exemplified the specified design and synthesis of MoS2 for high‐temperature CO2 reduction through the effective manipulation of distinct vacancy sites, shedding light on their potential industrial application.
Small‐Scale Recovery of a Native White‐Spotted Charr Population by Suppression of Non‐Native Brown Trout
Authors: Hasegawa Koh 
Published: January 2025

ABSTRACTIf eradication is not feasible, suppressing a population size of non‐native species by removal is an alternative option for the conservation of native species that are impacted by non‐native species invasions. This study reports on the suppression of non‐native brown trout for the conservation of native white‐spotted charr in an upstream of Monbetsu Stream, Hokkaido, northern Japan. Brown trout removals were conducted from 2014 to 2023 by electrofishing. The population size of brown trout was dramatically reduced during the first three years of removals, and the ratio of white‐spotted charr to brown trout abundance gradually increased. However, the population size of white‐spotted charr did not fully recover, which can be explained by the openness of the system and likely also by the influence of interfering factors observed during the study, such as changes in stream morphology due to flooding and suspected illegal fish stocking. The abundance of young‐of‐the‐year brown trout also tended to be reduced when numerous mature females had been removed in previous years. This study suggests that suppressing non‐native fish species, even on a limited scale, can contribute to the conservation of native species. However, when preventing migration from downstream into the target stream reach is unfeasible, ongoing suppression of non‐native species becomes essential to ensure the conservation of native species in the area.
Integrated Geophysical Search for 19th‐Century Underground Tanks in Krakow (Poland): Analysis of 2D, 2.5D and 3D ERT Surveys
Authors: Pasierb Bernadetta , Nawrocki Wiesław 
Published: January 2025

ABSTRACTThe paper presents the results of a noninvasive geophysical search for 19th‐century underground tanks located in the former Austrian imperial barracks complex of Archduke Rudolf in Krakow (Poland). The location of the tanks was necessary to assess their condition for safety reasons. Complementary geophysical methods in terms of field conditions and data acquisition, that is, magnetometry, ground penetrating radar (GPR) and electrical resistivity tomography (ERT), were used to locate the tanks. Interdisciplinary surveys made it possible to identify the subsurface structure, locate sewage settling tanks and verify archival documentation. The paper presents the problems that arise in imaging underground structures using applied geophysical methods. The aim of the study was also to assess the effectiveness of these methods in subsurface identification, including 2D, 2.5D and 3D ERT surveys. The applied sequence of measurements (magnetometric, GPR and ERT) proved to be correct and the most effective. It allowed for narrowing down the research area. Magnetometric measurements allowed for the location of iron elements related to the construction of the tanks. GPR measurements determined their range. The ERT results showed that 2D and 2.5D surveys conducted in the parallel‐line arrangement are as effective in determining the location of an anomalous object as the 3D orthogonal‐line arrangement. The 3D method enabled the identification of additional anomalies not detected by the 2.5D method. From the point of view of the practicality of both techniques, the 2.5D method turned out to be better than the 3D method, due to the simplicity of the fieldwork, lower spatial and hardware requirements, a greater depth range and lower complexity of data acquisition and processing.
Uncertainties in Ground‐Based Visual Double Star Measures
Authors: Letchford Roderick R. , White Graeme L. 
Published: January 2025

ABSTRACTStellar masses are found from the orbital elements of binary systems which are, in turn, computed from weighted astrometric measures. Astrometric measures of double stars (their position angle and separation) rarely include uncertainties, and published binary star orbits rarely include the weighting systems used in the determination of the orbital elements. Here we propose a simple method for estimating uncertainties of ground‐based measures of visual double stars based on precision space‐based astrometry of optical (not binary) double stars, which can be used as unbiased weights for all double star measures. The precision of ground‐based measures is examined as (i) a function of the date of observation, (ii) the telescope aperture, and (iii) the instrumentation (technique) used at the telescope. We also note in the Appendix, 19 pairs that are incorrectly described in Lin2 and six rectilinear pairs that may display curved motion.
Naa15 Haploinsufficiency and De Novo Missense Variants Associate With Neurodevelopmental Disorders and Interfere With Neurogenesis and Neuron Development
Authors: He Mei , Du Bing , Chen Guodong , Lyu Yongqing , Guo Hui , Jia Xiangbin , Xia Kun 
Published: January 2025

ABSTRACTNeurodevelopmental disorders (NDDs) encompass a group of conditions that impact brain development and function, exhibiting significant genetic and clinical heterogeneity. NAA15, the auxiliary subunit of the N‐terminal acetyltransferase complex, has garnered attention due to its association with NDDs. However, the precise role of NAA15 in cortical development and its contribution to NDDs remain elusive. By employing targeted sequencing on a large Chinese cohort affected by ASD and conducting an extensive literature review, we have compiled 64 distinct variants in the NAA15 gene identified among individuals with neurodevelopmental disorders. Our research demonstrates that loss of NAA15 leads to a substantial increase in neuronal count, potentially resulting in aberrant brain development and triggering repetitive as well as anxious behaviors in mice models. Furthermore, disorder‐associated variants within NAA15 impair axon and synapse formation processes crucial for neural connectivity establishment. These findings shed light on the consequences of NAA15 deficiency along with its de novo mutations on brain development while unraveling the cellular mechanisms underlying NDDs.
Elevating Red and Near‐Infrared Detectivity With CsSnI3 Perovskite Photodetectors Featuring GO and PCBM as Charge Transport Layers
Authors: Pandey Pallavi , Chaudhary Akhilesh Kumar , Verma Sudhanshu 
Published: January 2025

ABSTRACTThis study focuses on enhancing the performance of photodetector through the utilization of inorganic perovskite material. It emphasizes that the unique properties of perovskite materials contribute to the superior performance of the photodetector. The focus is on the design and enhancement of CsSnI3‐based photodetector having graphene oxide (GO) and PCBM as charge transport layer, analysing their potential for improved operation. The design process involves a series of optimizations to the device layers, particularly the absorber layer's thickness and defects, which is critical for enhanced efficiency. The designed photodetector exhibits a better responsivity and detectivity in red and near infrared region and maximum responsivity of 0.68 A/W and detectivity of 9 × 1012 Jones. The SCAPS‐1D tool is employed to facilitate the design analysis, enabling the fine‐tuning of the device parameters. The findings highlight the effectiveness of perovskite materials in boosting photodetector performance.
Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial
Authors: Ma Jianli , Wang Jingxuan , Xu Ting , Ouyang Quchang , Wang Xiaojia , Wang Jingfen , Gan Lu , Ouyang Zhong , Lin Daren , Sun Tao , Shan Changping , Yao Herui , Zhang Baochun , Li Zhengguang , Zhuang Zhixiang , Lu Ying , Yang Hongwei , Huang Jian , Yang Xingwang , Sun Hongmei , Zhang Qingyuan 
Published: January 2025

AbstractBackgroundThe standard first‐line treatment for human epidermal growth factor receptor 2 (HER2)‐positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti‐HER2 bispecific antibody, plus docetaxel in first‐line treatment of HER2‐positive recurrent/metastatic breast cancer.MethodsThis open‐label, single‐arm, phase II study enrolled patients with HER2‐positive recurrent/metastatic breast cancer in 19 centers across China from December 30, 2019 to May 27, 2021. Patients were administered KN026 (30 mg/kg) plus docetaxel (75 mg/m2) in 21‐day cycles. Primary endpoints included the objective response rate (ORR) and duration of response (DOR). In addition, overall survival (OS), progression‐free survival (PFS), clinical benefit rate (CBR) and safety profile were examined.ResultsA total of 57 patients were included. In the efficacy analysis set of 55 patients, the ORR was 76.4% (95% confidence interval [CI], 63.0%‐86.8%), and the CBR was 85.5% (95% CI, 73.3%‐93.5%). The median DOR was not reached (95% CI, 20.7 months‐not reached). In the safety set of 57 patients, the median PFS was 27.7 months (95% CI, 18.0 months‐not reached). The median OS was not reached, with OS rates at 12, 24 and 30 months of 93.0%, 84.1% and 78.5%, respectively. Grade ≥3 treatment‐emergent adverse events (AEs) were detected in 36 (63.2%) patients. No deaths were attributed to KN026 or docetaxel.ConclusionKN026 plus docetaxel showed promising efficacy and a manageable safety profile in first‐line treatment of HER2‐positive recurrent/metastatic breast cancer.
Adult Attachment Style, Emotion Regulation and Obsessive–Compulsive Disorder—A Preliminary Cross‐Sectional Mediational Investigation of an Attachment‐Based Model
Authors: Nielsen Sara Kerstine Kaya , Stuart Anne Christine , Winding Clas , Pedersen Mette Øllgaard , Daniel Sarah Ingrid Franksdatter , Vangkilde Signe , Rosenberg Nicole , Hageman Ida , Petersen Anders , Jørgensen Martin Balslev 
Published: January 2025

ABSTRACTThere is evidence that emotion regulation plays a role in the aetiology and maintenance of OCD, but knowledge about what impacts emotion dysregulation is limited. Attachment style is related to both emotion regulation and OCD symptoms, but the link between them has not been thoroughly studied. Examining emotion dysregulation within the context of OCD through an attachment theory framework may lead to a better understanding of the aetiology and maintenance of OCD. In the present study, we combined theoretically and empirically derived knowledge to examine the mediating role of emotion regulation between attachment dimensions (avoidance and anxiety) and OCD symptoms. One‐hundred seventy‐nine individuals with OCD were assessed with Experiences in Close Relationships‐Revised (ECR‐R), Difficulties in Emotion Regulation Scale (DERS) and Yale‐Brown Obsession Compulsion Scale (Y‐BOCS), and mediation analyses were conducted. Our results indicate that the association between OCD and attachment anxiety/avoidance was mediated by emotion dysregulation. The primary limitation of our study is that data are cross‐sectional and, therefore, we cannot infer anything about the causal direction of these relationships. A second limitation of the study is that two of the three measures were derived from self‐reported questionnaires, which may be prone to biassed reporting. Our results suggest that insecure attachment is important in OCD when taking emotion regulation into account. Thus, clinical interventions for OCD may improve by targeting attachment and difficulties related to emotion regulation. However, our findings are based on cross‐sectional data that preclude conclusions relating to causal influence.