bluuebunny/crossref_metadata_2025_split huggingface dataset:
Listening campaigns: engaging clinicians to assess system factors contributing to burnout
Authors: Richards Sarah E , Kennel Victoria , Wardian Jana , Carlson Kristy , Lowndes Bethany 
Published: July 2023

BackgroundEven prior to the pandemic, many US physicians experienced burnout affecting patient care quality, safety and experience. Institutions often focus on personal resilience instead of system-level issues. Our leaders developed a novel process to identify and prioritise key system-related solutions and work to mitigate factors that negatively impact clinician well-being through a structured listening campaign.MethodsThe listening campaign consists of meeting with each clinician group leader, a group listening session, a follow-up meeting with the leader, a final report and a follow-up session. During the listening session, clinicians engage in open discussion about what is going well, complete individual reflection worksheets and identify one ‘wish’ to improve their professional satisfaction. Participants rate these wishes to assist with prioritisation.ResultsAs of January 2020, over 200 clinicians participated in 20 listening sessions. One hundred and twenty-two participants completed a survey; 80% stated they benefited from participation and 83% would recommend it to others.ConclusionCollecting feedback from clinicians on their experience provides guidance for leaders in prioritising initiatives and opportunities to connect clinicians to organisational resources. A listening campaign is a tool recommended for healthcare systems to elicit clinician perspectives and communicate efforts to address systemic factors.
Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment
Authors: Wu Shaoxian , Huang Hao , Sun Runzi , Gao David Shihong , Ye Fan , Huang Jianing , Li Ella , Ni Andrew , Lu Kevin GuoKai , Chen Kong , Jiang Jingting , Morel Penelope A. , Zhong Ziyang , Lu Binfeng 
Published: July 2023

T cell–stimulating cytokines and immune checkpoint inhibitors (ICI) are an ideal combination for increasing response rates of cancer immunotherapy. However, the results of clinical trials have not been satisfying. It is important to understand the mechanism of synergy between these two therapeutic modalities. Here, through integrated analysis of multiple single-cell RNA sequencing (scRNA-seq) datasets of human tumor-infiltrating immune cells, we demonstrate that IL21 is produced by tumor-associated T follicular helper cells and hyperactivated/exhausted CXCL13+CD4+ T cells in the human tumor microenvironment (TME). In the mouse model, the hyperactivated/exhausted CD4+ T cell–derived IL21 enhances the helper function of CD4+ T cells that boost CD8+ T cell–mediated immune responses during PD-1 blockade immunotherapy. In addition, we demonstrated that IL21’s antitumor activity did not require T-cell trafficking. Using scRNA-seq analysis of the whole tumor-infiltrating immune cells, we demonstrated that IL21 treatment in combination with anti-PD-1 blockade synergistically drives tumor antigen–specific CD8+ T cells to undergo clonal expansion and differentiate toward the hyperactive/exhausted functional state in the TME. In addition, IL21 treatment and anti-PD-1 blockade synergistically promote dendritic cell (DC) activation and maturation to mature DC as well as monocyte to type 1 macrophage (M1) differentiation in the TME. Furthermore, the combined treatment reprograms the immune cellular network by reshaping cell-cell communication in the TME. Our study establishes unique mechanisms of synergy between IL21 and PD-1–based ICI in the TME through the coordinated promotion of type 1 immune responses.

Significance:
This study reveals how cytokine and checkpoint inhibitor therapy can be combined to increase the efficacy of cancer immunotherapy.
Yugoslav Emigrants in Brazil from the Habsburgs to Karađorđevićs: Transnational Political Engagement on the Peripheries?
Authors: Zobec Miha 
Published: July 2023

Abstract
This article addresses how the Habsburg Empire and interwar Yugoslavia engaged with their emigrants in Brazil, and examines emigration patterns. It suggests that despite these emigrants not insignificant presence in Brazil, both European states demonstrated minimal interest in their subjects in the largest Latin American country. By contrast, the emigrants themselves aimed at attracting their home state’s attention, thus making the Yugoslav emigrant network visible. Tracing emigrant transnational political practices on the eve of the First World War, this article examines the establishment and withering of the South Slavic community in Brazil. It does so by situating the emigrant network within the transnational social field, defined by the sending and receiving states and by emigrant activists. Without oversight from the home state, and restrictive policies by the receiving country, these activists manipulated emigrants’ interests for personal benefit, contributing to community disruption before the Second World War.
Northern Irish Migrants in Glasgow and the Troubles in Great Britain: Echoes of Conflict in a ‘Home Away from Home’
Authors: Crangle Jack , Harte Liam , Dawson Graham , Roulston Fearghus , Hazley Barry 
Published: July 2023

Abstract
This article diversifies and deepens our understanding of Northern Irish settlement in Great Britain during the era of the Troubles (c.1969–1998) by exploring a previously under-researched destination: the West of Scotland. Featuring oral history interviews with Northern Irish migrants in Glasgow, it considers how centuries of cultural exchange between the two places shaped migrants’ memories and subjectivities. Our narrators’ childhoods in Northern Ireland were punctuated by sectarian rancour and conflict. The presence in Scotland of similar – albeit less violent or systemic – sectarian attitudes often acted as mnemonic triggers to a conflict migrants felt they had left behind, reopening psychological wounds and reviving repressed traumas. Informed by theoretical conceptions of home, the analysis examines convergences between home and elsewhere, disrupting the idea of migration as a severance between the two. The article therefore offers a new perspective on both the Northern Irish presence in Great Britain and on interreligious relations in the West of Scotland.
Berlin nodules: About 3 cases
Authors: Kharrat Malek , Kallel Zeineb , Sayadi Sana , Krifa Hamza , Zbiba Walid 
Published: July 2023

Introduction Granulomatous uveitis is mainly defined by the nature of keratic precipitates and iris nodules. Anterior chamber (AC) granulomas, also known as Berlin nodules (BN), are circumscribed granulomatous nodules that form in the iridocorneal angle (ICA) in response to intraocular inflammation. Cases description We present three representative cases of anterior uveitis with berlin nodules to insist on the clinical features of this entity. Case 1: A female adult was referred to our department for bilateral redness and gradual blurry vision. Slit-lamp examination of both eyes (OU) found a yellow-white nodular mass at 6 o’clock on the peripheral iris with irido-crystalline synechiae, vitreous haze and blurred fundus. Purified protein derivative skin test revealed an induration of 20 mm. A diagnosis of presumed ocular tuberculosis was made. The patient received antituberculosis drugs and steroids with good evolution. Case 2: An 11-year-old girl presented for redness and pain OU. Anterior segment examination showed circumciliary congestion, epithelial microcystic edema OU and pearly vascularized lesion against the cornea in the right eye. Fundus examination was unremarkable. A diagnosis of definite ocular sarcoidosis was made based on accessory salivary glands biopsy. The patient was treated with teroids and controlled twice a week. Case 3: A 26-year-old male presented with a redness and pain of the left eye. The slit-lamp examination showed fine keratic precipitates with pearly white nodules within the AC. Fundus examination showed a chorioretinal lesion and occlusive vasculitis. Chest CT was consistent with milliary tuberculosis. Adequate therapy was initiated with favorable outcome Conclusion BN can be associated with various ocular manifestations of several diseases. They may be the first manifestation of systemic conditions and seem to be well managed with topical steroids.
Smartphone use and well-being in Pakistan: Comparing the effect of self-reported and actual smartphone use
Authors: Ejaz Waqas , Altay Sacha , Naeem Ghazala 
Published: July 2023

Objective Past work has shown that smartphone use has negative effects on well-being. Yet, most evidence relies on self-reported measures of smartphone use and comes from Western democracies. We examined the relationship between both self-reported and actual smartphone use and well-being in Pakistan, a country that is under-researched in the Global South. Additionally, we investigated the moderating effect of the fear of missing out (FoMO). Methods We conducted an online survey among 427 Pakistani citizens. Participants reported their smartphone use and well-being (i.e., levels of depression, loneliness, and life satisfaction). At the end of the survey, participants were asked to upload screenshots of their respective ‘Screen Time’ (for iOS) or ‘Digital Well-being’ (for Android) apps, which we used to measure their actual smartphone use. Results We found a moderate association between self-reported and actual smartphone use ( r = .36); on average, participants underreported their daily smartphone use by 11 min. Actual smartphone use was negatively associated with well-being, while self-reported use showed no statistically significant association. FoMO was positively associated with actual smartphone use but not with self-reported use. Finally, FoMO moderated the relationship between self-reported use and well-being. Conclusion Our findings show that the relationship between smartphone use and well-being depends on how smartphone use is measured and is moderated by FoMO. Moreover, we find that mobile data donation is viable in Pakistan, which should encourage future research to use it as a complement to self-reported media use more often.
Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia
Authors: Senapati Jayastu , Urrutia Samuel , Loghavi Sanam , Short Nicholas J. , Issa Ghayas C. , Maiti Abhishek , Abbas Hussein A. , Daver Naval G. , Pemmaraju Naveen , Pierce Sherry , Chien Kelly S. , Sasaki Koji , Kadia Tapan M. , Hammond Danielle E. , Borthakur Gautam , Patel Keyur , Ravandi Farhad , Kantarjian Hagop M. , Garcia-Manero Guillermo , DiNardo Courtney D. 
Published: July 2023

Abstract
Mutations in splicing factor (SF) genes SRSF2, U2AF1, SF3B1, and ZRSR2 are now considered adverse risk in the European LeukemiaNet 2022 acute myeloid leukemia (AML) risk stratification. The prognostic impact of SF mutations in AML has been predominantly derived from younger patients treated with intensive (INT) therapy. We evaluated 994 patients with newly diagnosed AML, including 266 (27%) with a SFmut. Median age was 67 years overall, with patients with SFmut being older at 72 years. SRSF2 (n = 140, 53%) was the most common SFmut. In patients treated with INT, median relapse-free survival (RFS) (9.6 vs 21.4 months, P = .04) and overall survival (OS) (15.9 vs 26.7 months, P = .06) were shorter for patients with SFmut than without SFwt, however this significance abrogated when evaluating patients who received venetoclax with INT therapy (RFS 15.4 vs 20.3 months, P = .36; OS 19.6 vs 30.7 months, P = .98). In patients treated with LI, median RFS (9.3 vs 7.7 months, P = .35) and OS (12.3 vs 8.5 months, P = .14) were similar for patients with and without SFmut , and outcomes improved in all groups with venetoclax. On multivariate analysis, SFmut did not affect hazards of relapse and death for INT arm but reduced both these hazards in LI arm. In a large AML data set with &gt;60% of patients receiving venetoclax with LI/INT therapy, SFmut had no independent negative prognostic impact. Newer prognostic models that consider LI therapy and use of venetoclax among other factors are warranted.
Oxidised IL-33 drives COPD epithelial pathogenesisviaST2-independent RAGE/EGFR signalling complex
Authors: Strickson Sam , Houslay Kirsty F. , Negri Victor A. , Ohne Yoichiro , Ottosson Tomas , Dodd Roger B. , Huntington Catherine Chaillan , Baker Tina , Li Jingjing , Stephenson Katherine E. , O'Connor Andy J. , Sagawe J. Sophie , Killick Helen , Moore Tom , Rees D. Gareth , Koch Sofia , Sanden Caroline , Wang Yixin , Gubbins Elise , Ghaedi Mahboobe , Kolbeck Roland , Saumyaa Saumyaa , Erjefält Jonas S. , Sims Gary P. , Humbles Alison A. , Scott Ian C. , Romero Ros Xavier , Cohen E. Suzanne 
Published: July 2023

BackgroundEpithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammationviaits receptor, serum stimulation-2 (ST2). Oxidation of IL-33 to a non-ST2-binding form (IL-33ox) is thought to limit its activity. We investigated whether IL-33oxhas functional activities that are independent of ST2 in the airway epithelium.MethodsIn vitroepithelial damage assays and three-dimensional, air–liquid interface (ALI) cell culture models of healthy and COPD epithelia were used to elucidate the functional role of IL-33ox. Transcriptomic changes occurring in healthy ALI cultures treated with IL-33oxand COPD ALI cultures treated with an IL-33-neutralising antibody were assessed with bulk and single-cell RNA sequencing analysis.ResultsWe demonstrate that IL-33oxforms a complex with receptor for advanced glycation end products (RAGE) and epidermal growth factor receptor (EGFR) expressed on airway epithelium. Activation of this alternative, ST2-independent pathway impaired epithelial wound closure and induced airway epithelial remodellingin vitro. IL-33oxincreased the proportion of mucus-producing cells and reduced epithelial defence functions, mimicking pathogenic traits of COPD. Neutralisation of the IL-33oxpathway reversed these deleterious traits in COPD epithelia. Gene signatures defining the pathogenic effects of IL-33oxwere enriched in airway epithelia from patients with severe COPD.ConclusionsOur study reveals for the first time that IL-33, RAGE and EGFR act together in an ST2-independent pathway in the airway epithelium and govern abnormal epithelial remodelling and muco-obstructive features in COPD.
Operational blue water footprint and water deficit assessment of coal-fired power plants: case study in Malaysia
Authors: Mardi Nurul Hani , Ean Lee Woen , Malek Marlinda Abdul , Chua Kok Hua , Ahmed Ali Najah 
Published: July 2023

AbstractFreshwater is an essential resource used to generate electricity at coal-fired power plants. Previous literature has shown that a few states in Malaysia will face a high risk of water stress. Hence, coal-fired power plants located at risk states are exposed to potential water risk. This study aims (i) to determine the operational blue water footprint at coal-fired power plant from 2009 until 2020; (ii) to assess the water stress index at Perak, Negeri Sembilan and Johor; and (iii) to compare the water deficit impact across three states. This study accounted the operational water footprint using Water Footprint Assessment Global Manual. The study boundary focuses on water consumption of generating electricity at operational level. The water stress index was assessed based on ratio of water demand and water availability at Perak, Negeri Sembilan and Johor watershed. Next water deficit impact was determined to compare the impact of operational blue water footprint on local water resources. Data for this study were collected from the state’s water authority, published literature, national reports, and statistics. Result of this study found the average operational blue water footprint recorded by coal-fired power plant located at Perak is 0.11 m3/MWh followed 0.09 m3/MWh (Johor) and 0.04 m3/MWh (Negeri Sembilan). Water stress index at Perak and Negeri Sembilan shows moderate water stress, whereas Johor indicates low water stress index. The water deficit result shows Perak has the highest total water deficit at 12,542,824 m3H2Oeqn from 2009 to 2020. This is due to moderate water stress condition at Perak and the total blue water footprint of coal-fired power plant at Perak is 67% and 42% more as compared to Negeri Sembilan and Johor, respectively. The result from this study is useful in enhancing understanding of water consumption pattern at coal-fired power plant and its impact on state’s water resources for future electricity scenarios.
Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism
Authors: Liu Xin , Ke Leyong , Lei Ke , Yu Qian , Zhang Wenqing , Li Changgui , Tian Zibin 
Published: July 2023

Abstract
Background
Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to explore the mechanisms through which microbiomes affect UA metabolism with the hypothesis that modifying the intestinal microbiota influences the development of hyperuricemia.

Results
We proposed combining an antibiotic strategy with protein-protein interaction analysis to test this hypothesis. The data demonstrated that antibiotics altered the composition of gut microbiota as UA increased, and that the spectrum of the antibiotic was connected to the purine salvage pathway. The antibiotic-elevated UA concentration was dependent on the increase in microbiomes that code for the proteins involved in purine metabolism, and was paralleled by the depletion of bacteria-coding enzymes required for the purine salvage pathway. On the contrary, the microbiota with abundant purine salvage proteins decreased hyperuricemia. We also found that the antibiotic-increased microbiota coincided with a higher relative abundance of bacteria in hyperuricemia mice.

Conclusions
An antibiotic strategy combined with the prediction of microbiome bacterial function presents a feasible method for defining the key bacteria involved in hyperuricemia. Our investigations discovered that the core microbiomes of hyperuricemia may be related to the gut microbiota that enriches purine metabolism related-proteins. However, the bacteria that enrich the purine salvage-proteins may be a probiotic for decreasing urate, and are more likely to be killed by antibiotics. Therefore, the purine salvage pathway may be a potential target for the treatment of both hyperuricemia and antibiotic resistance.
Purslane-induced oxalate nephropathy: case report and literature review
Authors: Wang Xiangtuo , Zhang Xiaoyan , Wang Liyuan , Zhang Ruiying , Zhang Yingxuan , Cao Lei 
Published: July 2023

Abstract
Background
The kidney is particularly vulnerable to toxins due to its abundant blood supply, active tubular reabsorption, and medullary interstitial concentration. Currently, calcium phosphate-induced and calcium oxalate-induced nephropathies are the most common crystalline nephropathies. Hyperoxaluria may lead to kidney stones and progressive kidney disease due to calcium oxalate deposition leading to oxalate nephropathy. Hyperoxaluria can be primary or secondary. Primary hyperoxaluria is an autosomal recessive disease that usually develops in childhood, whereas secondary hyperoxaluria is observed following excessive oxalate intake or reduced excretion, with no difference in age of onset. Oxalate nephropathy may be overlooked, and the diagnosis is often delayed or missed owning to the physician’s inadequate awareness of its etiology and pathogenesis. Herein, we discuss the pathogenesis of hyperoxaluria with two case reports, and our report may be helpful to make appropriate treatment plans in clinical settings in the future.

Case presentation
We report two cases of acute kidney injury, which were considered to be due to oxalate nephropathy in the setting of purslane (portulaca oleracea) ingestion. The two patients were elderly and presented with oliguria, nausea, vomiting, and clinical manifestations of acute kidney injury requiring renal replacement therapy. One patient underwent an ultrasound-guided renal biopsy, which showed acute tubulointerstitial injury and partial tubular oxalate deposition. Both patients underwent hemodialysis and were discharged following improvement in creatinine levels.

Conclusions
Our report illustrates two cases of acute oxalate nephropathy in the setting of high dietary consumption of purslane. If a renal biopsy shows calcium oxalate crystals and acute tubular injury, oxalate nephropathy should be considered and the secondary causes of hyperoxaluria should be eliminated.
Maternal wellbeing of Malaysian mothers after the birth of a preterm infant
Authors: Jones Liz , Mariapun Jeevitha , Tan Abbey Xiao Qian , Kassim Zaid , Su Tin Tin 
Published: July 2023

Abstract
Background
In Malaysia approximately 7% of births result in a preterm birth (< 37 weeks). Research in many other countries has found that mothers of preterm infants experience poorer psychological wellbeing. However, there has been limited research in Malaysia. We examined wellbeing, using the WHO Quality of Life brief version questionnaire (WHOQOL-BREF), in mothers who have preterm and full-term infants.

Methods
Data was collected as part of the South East Asian Community Observatory MISS-P project. A total of 3221 mothers (7.9% with a preterm and 92.1 with a full-term birth) completed a survey, with a range of measures, including the WHOQoL-BREF and sociodemographic questions.

Results
For the physical health, psychological wellbeing and quality of their environment WHOQOL-BREF domains, a lower gestational age, a lower education level, and having had an emergency caesarean delivery were significantly associated (p < 0.05) with a lower quality of life, and there was a weak effect for ethnicity for some domains. The effects were strongest for mothers’ education level.

Conclusions
There is a weak but significant relationship between the gestational age of an infant and the mother’s quality of life. Mothers in Malaysia with a preterm infant or a lower level of education may benefit from additional support.
Influence of psychosocial safety climate on occupational health and safety: a scoping review
Authors: Amoadu Mustapha , Ansah Edward Wilson , Sarfo Jacob Owusu 
Published: July 2023

Abstract
Background
Creating a healthy, decent and safe workplace and designing quality jobs are ways to eliminate precarious work in organisations and industries. This review aimed at mapping evidence on how psychosocial safety climate (PSC) influence health, safety and performance of workers.

Methods
A literature search was conducted in four main databases (PubMed, Scopus, Central and Web of Science) and other online sources like Google Scholar. A reference list of eligible studies was also checked for additional papers. Only full-text peer-reviewed papers published in English were eligible for this review.

Results
A search in the databases produced 13,711 records, and through a rigorous screening process, 93 papers were included in this review. PSC is found to directly affect job demands, job insecurity, effort-reward imbalance, work-family conflict, job resources, job control and quality leadership. Moreover, PSC directly affects social relations at work, including workplace abuse, violence, discrimination and harassment. Again, PSC has a direct effect on health, safety and performance outcomes because it moderates the impact of excessive job demands on workers’ health and safety. Finally, PSC boosts job resources’ effect on improving workers’ well-being, safety and performance.

Conclusion
Managers’ efforts directed towards designing quality jobs, prioritising the well-being of workers, and fostering a bottom-up communication through robust organisational policies, practices, and procedures may help create a high organisational PSC that, in turn, promotes a healthy and decent work environment.