bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health effects of air pollutant mixtures (volatile organic compounds, particulate matter, sulfur and nitrogen oxides) – a review of the literature
Authors: Fazakas Emese , Neamtiu Iulia A. , Gurzau Eugen S. 
Published: March 2023

Abstract
The health risks associated with individual air pollutant exposures have been studied and documented, but in real-life, the population is exposed to a multitude of different substances, designated as mixtures. A body of literature on air pollutants indicated that the next step in air pollution research is investigating pollutant mixtures and their potential impacts on health, as a risk assessment of individual air pollutants may actually underestimate the overall risks. This review aims to synthesize the health effects related to air pollutant mixtures containing selected pollutants such as: volatile organic compounds, particulate matter, sulfur and nitrogen oxides. For this review, the PubMed database was used to search for articles published within the last decade, and we included studies assessing the associations between air pollutant mixtures and health effects. The literature search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A number of 110 studies were included in the review from which data on pollutant mixtures, health effects, methods used, and primary results were extracted. Our review emphasized that there are a relatively small number of studies addressing the health effects of air pollutants as mixtures and there is a gap in knowledge regarding the health effects associated with these mixtures. Studying the health effects of air pollutant mixtures is challenging due to the complexity of components that mixtures may contain, and the possible interactions these different components may have.
A bibliometric and visual analysis of social semiotics: development, hotspots, and trend directions
Authors: Xiao Han , Li Lei 
Published: March 2023

Abstract
Social semiotics is now widely regarded as one of the leading research areas. This study is the first attempt to present a holistic overview of social semiotics based on the data in the Web of Science core collection database from 2001 to 2020. The study investigates, among other issues, social semiotics’ publishing tendency, the most productive authors, countries, institutions, and hotspots. The results exhibit a steady rise in its publications and citations. The current analysis verifies the growing quantitative and qualitative research contributions and influences of this field. Furthermore, what the journals focus on are the innovative and contemporary themes, manifested predominantly in sign, multimodality, gender, experimental semiotics, advertising, culture, and social media, which involve a wide range of methodologies to make the research more acceptable and constructive. These results are expected to offer refreshing insights that inspire scholars in formulating scientific agendas and advising their research strategies, thereby facilitating substantial contributions to the domain.
Творець хлібного достатку України — вагомої складової національної безпеки держави
Authors: Коць Сергій Ярославович 
Published: March 2023

10 березня виповнилося 85 років видатному українському вченому-генетику, селекціонеру рослин, Герою України (2008), лауреату Державних премій у галузі науки і техніки СРСР (1986), УРСР (1982) та України (1997), заслуженому діячеві науки і техніки (1998), лауреату Золотої медалі імені В.І. Вернадського (2017) і премії імені В.Я. Юр’єва (1993) НАН України, директору Інституту фізіології рослин і генетики НАН України (з 1986), доктору біологічних наук (1980), професору (1988), академіку НАН України (1990) Володимиру Васильовичу Моргуну.
Influence of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization: results of a randomized trial
Authors: Oleynik B. A. , Plechev V. V. , Evdakov V. A. , Izhbuldin R. I. , Zagidullin N. Sh. 
Published: March 2023

Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization.Material and methods. This prospective, randomized, single-center study included two following groups: experimental group — 25 patients in the perioperative period of coronary artery bypass grafting (5 days before and 14 days after surgery) receiving 5-hydroxymethyluracil (at a dose of 500 mg 3 times a day) in addition to standard therapy; control group — 25 patients receiving standard therapy. The groups were comparable in terms of sex, age, main clinical and functional characteristics and features of surgical intervention. In patients, quantitative indicators of angiogenic growth factors in peripheral blood taken 5 days before and 14 days after surgery were studied by enzyme immunoassay: human vascular endothelial growth factor A (VEGF-A), human hepatocyte growth factor (hHGF), insulin-like factor growth 1 (IGF-1) and basic fibroblast growth factor (bFGF).Results. In the experimental group of patients, while taking 5-hydroxymethyluracil, there was a significant increase in the peripheral blood concentration of following growth factors compared with the control group: VEGF-A by 26,90% (p=0,0246), IGF-1 by 44,89% (p=0,0011), bFGF by 60,0% (p=0,0006). The hHGF concentration also turned out to be higher by 19,90%, but did not reach the level of statistical significance (p=0,2836).Conclusion. The use of 5-hydroxymethyluracil, a representative of pyrimidines, in the perioperative period of surgical myocardial revascularization leads to a significant increase in peripheral blood of such angiogenic growth factors as VEGF-A, IGF-1, and bFGF.
Omega-3 polyunsaturated fatty acids in the prevention of postoperative atrial fibrillation in open heart surgery: a systematic review and meta-analysis
Authors: Rubanenko O. A. , Rubanenko A. O. , Davydkin I. L. 
Published: March 2023

Aim. To evaluate the literature data on the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative atrial fibrillation (POAF) in elective cardiac surgery, including onor off-pump coronary artery bypass grafting and/or valve replacement and/or repair.Material and methods. The search for studies was carried out using the PubMed database and Google Scholar from 2005 to January 31, 2022. From the initially identified search results, 19 articles were analyzed. The design of articles corresponded to randomized clinical trials. Omega-3 PUFAs was selected as an interventional effect. The studies were to include, as an end point, the assessment of new POAF cases in the early period after open heart surgery.Results. The meta-analysis included 15 studies with 3980 patients, of which 1992 (50,0%) patients took omega-3 PUFAs. POAF occurred in 587 (29,5%) patients receiving omega-3 PUFAs and 679 (34,2%) patients on standard therapy (hazard ratio, 0,8, 0,68-0,93, p=0,004). There is a variation in effect size for POAF patients in the presented randomized clinical trials relative to the axis of the central trend and heterogeneity of studies with a significant number of patients included (I2=51%, p=0,01).Conclusion. Our systematic review and meta-analysis showed the effectiveness of omega-3 PUFAs in the prevention of POAF during open heart surgery.
Prevalence of professional burnout among practicing cardiologists in the constituent entities of the Russian Federation
Authors: Neplyueva G. A. , Soloveva A. E. , Krovopolenova S. D. , Solovev A. E. , Zaitsev V. V. , Zvartau N. E. , Konradi A. O. , Villevalde S. V. 
Published: March 2023

The burnout syndrome among healthcare professionals is a headline problem in the world, as it leads to poor health of medical workers, affects patient satisfaction with health care and the healthcare system as a whole. At the same time, existing preventive measures can improve the well-being of staff.Aim. To study the prevalence of professional burnout syndrome among practicing cardiologists in the Russian Federation (RF).Material and methods. This cross-sectional study was carried out using the method of online anonymous surveying. The inclusion criterion was the current practical activity in the RF. The study involved 452 cardiologists from 8 federal districts (women; n=377, 83,4%), 48,2% of which worked in a hospital. Occupational burnout was assessed using the Maslach Burnout Inventory (MBI) questionnaire in the Russian language adaptation for healthcare workers by N. E. Vodopyanova and E. S. Starchenkova. The score was calculated on three subscales (emotional exhaustion, depersonalization, personal accomplishment), the maximum score for the subscales was 54, 30 and 48, respectively. The personal accomplishment subscale is the opposite as follows: the higher the score, the less the symptom severity. Additionally, demographic parameters, working conditions, the desire to change job and field of activity were taken into account. Regression analysis was used to establish associations of burnout with factors.Results. The median score of the emotional exhaustion subscale was 29,5 (23,0; 35,0) points, depersonalization — 12,0 (8,0; 16,0) and personal accomplishment — 32,0 (28,0; 37,0). Men had higher depersonalization score than women as follows: 15,0 (10,0; 18,0) vs 11,0 (8,0; 15,0), p=0,001. High degrees of emotional exhaustion and depersonalization (burnout) were found in 235 (52%) cardiologists, while all three symptoms simultaneously — in 132 (29,2%) doctors. There were no symptoms of burnout in 84 (18,6%) cardiologists. A high degree of burnout was associated with a desire to change job (p<0,001).Conclusion. A high prevalence of professional burnout among practicing cardiologists in the RF was revealed, which, in turn, is associated with the desire to change job or occupation.
Impact of assessment of fractional flow reserve and instantaneous wave-free ratio on clinical outcomes of percutaneous coronary intervention: a systematic review, meta-analysis and meta-regression analysis
Authors: Golukhova E. Z. , Petrosian K. V. , Abrosimov A. V. , Bulaeva N. I. , Goncharova E. S. , Berdibekov B. Sh. 
Published: March 2023

Aim. To conduct a systematic review and meta-analysis to compare clinical outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) using conventional coronary angiography (CAG) or fractional flow reserve (FFR)-guided PCI. In addition, FFR-guided PCI and PCI guided with instantaneous wave-free ratio (iFR) were compared.Material and methods. PubMed, Google Scholar databases were searched for studies comparing clinical outcomes in patients with CAD undergoing CAG-guided or FFR/iFR-guided PCI. Dichotomous data analysis was presented as odds ratio (OR) with 95% confidence interval (CI). Adjusted hazard ratio (HR) values from studies with similar evaluation criteria were pooled for meta-analysis.Results. Six randomized controlled trials (RCTs) from 184 publications were selected for this systematic review and meta-analysis. A total of 2193 patients (mean age, 64,2 years, mean follow-up, 28,0 months) were included. Analysis of RCTs showed that CAG-guided and FFR-guided PCI did not have a significant difference in the incidence of major adverse cardiovascular events (MACE) (OR: 0,78; 95% CI: 0,61-1,00; p=0,05; I2=0%), all-cause death (OR: 0,86; 95% CI: 0,51-1,44; p=0,57; I2=0%) or emergency revascularization (OR: 0,69, 95% CI: 0,46-1,04, p=0,08, I2=0%). However, FFR-guided PCI was associated with a reduced risk of subsequent MI compared with CAG-guided PCI (OR: 0,70; 95% CI: 0,50-0,99; p=0,04; I2=0%). In addition to the results of previous RCTs, we conducted a metaanalysis of 3 observational studies. In total, the CAG-guided and FFR-guided PCI groups included 165012 and 11450 patients, respectively. A meta-analysis showed that FFR-guided PCI was associated with a reduced risk of all-cause mortality (HR: 0,74; 95% CI: 0,63-0,87; P=0,0003) and MI (HR: 0,75; 95% CI: 0,61-0,94; p=0,01). In addition, there was no significant difference between iFRand FFR-guided PCI in terms of MACE (OR: 0,97; 95% CI: 0,76-1,23; p=0,81), all-cause mortality (OR: 0,66; 95% CI: 0,40-1,10; p=0,11), MI (OR: 0,83; 95% CI: 0,56-1,24; p=0,37) or emergency repeated revascularization (OR: 1,16; 95% CI: 0,85-1,58; p=0,34).Conclusion. FFR-guided PCI is associated with a reduced risk of all-cause mortality and subsequent MI compared with CAG-guided PCI. At the same time, the iFR-guided PCI is not inferior to the FFR-guided method in terms of MACE rate.
Clinical characteristics and frequency of anticoagulation in patients with atrial fibrillation and heart failure: results of a retrospective big data analysis
Authors: Druzhilov M. A. , Kuznetsova T. Yu. , Gavrilov D. V. , Andreichenko A. E. , Novitsky R. E. 
Published: March 2023

Aim. To evaluate the clinical characteristics and frequency of prescribed anticoagulant therapy for patients with atrial fibrillation (AF) and heart failure (HF) in subjects of the Russian Federation based on a retrospective big data analysis using artificial intelligence technologies.Material and methods. For retrospective analysis, information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of outand/ or inpatients in 6 subjects of the Russian Federation, extracted using artificial intelligence technologies. From the database of patients with AF (n=144431), a group of individuals (n=20970) with an established diagnosis of HF and information on left ventricular ejection fraction (LVEF) was selected.Results. Patients with AF and HF (men, 43,7%; age 72,1±13,2 years; LVEF, 58,9±11,0%) had a history of smoking in 36,6% of cases, hypertension — in 86,7%, type 2 diabetes — in 26,6%, gout — in 2,7%, stage III and IV-V chronic kidney disease — in 50,9 and 15,6%, lower limb peripheral arterial disease — in 15,8%. The incidence of ischemic stroke, LV myocardial infarction and pulmonary embolism was 8,8, 14,7 and 2,4%, respectively. Anticoagulants, including direct oral ones, were administered to patients with AF and HF in 62,5% and 32,0% of cases, respectively. The frequency of their appointment did not significantly differ depending on LVEF.Conclusion. Patients with AF and HF are characterized by significant comorbidity, a higher incidence of cardiovascular events compared with the group of individuals with AF without HF, and an unsatisfactory percentage of anticoagulant therapy.
Dambreak Risk Analysis of Jenelata Dam and its Mitigation Plan
Authors: Sandi Calvin , Nugroho Eka Oktarianto , Cahyono M. 
Published: March 2023

Makassar City is often experiences flood during rainy season and lack of water during dry season. Therefore, Jenelata Dam is planned to be built in South Sulawesi with a watershed area of 221.22 km2. Every dam has a dambreak potential due to many factors such as earthquakes. Risk analysis is carried out in order to study the most effective mitigation plan on minimizing the risk index. Flood hydrograph modeling due to dambreak is done using HEC-HMS with the most extreme dambreak scenario is due to overtopping with a discharge peak of 48726.47 m3/s. The flood inundation modeling is done using HEC-RAS with the inundation area due to overtopping was 20842.48 Ha. The results of the inundation map and demographic data are then used as the basis for determining the risk index per sub-district. The mitigation plan is in the form of structural and non-structural. The structural solution was determined through testing the effectiveness of every solution on reducing the flood inundation area, where the installation of embankments with 150 cm high on the main and river branch give the best result. Implementation of the mitigation plan is based on the risk index value of the sub-district and its components. The final result is a risk index with implementation of the mitigation plan as a comparison to the risk index without the mitigation plan. The result obtained is a decrease in the risk index on several sub-districts from high to medium or medium to low.
Simulasi Back Propagation Dalam Prediksi Data Kunjungan Kapal Dalam dan Luar Negeri Sumatera Selatan Tahun 2019 sampai 2021
Authors: Firdausa Fadhila , Ibrahim Ibrahim , Herius Andi , Prayuda Hakas 
Published: March 2023

Kondisi Sumatera Selatan yang memiliki sungai musi yang panjang dan berbatasan dengan. Kepulauan Bangka Belitung membuat perjalanan lalu lintas keairan menjadi perhatian penting. Selain itu hasil sumber daya Sumatera Selatan berupa minyak, gas alam, dan batu bara dan lain-lain menjadi pusat industri yang pemasarannya melalui jalur darat dan laut. Berdasarkan hasil ekspor import pelabuhan Boom Baru merupakan akses ekspor import terbesar di Sumatera Selatan. Oleh karena hal itu kunjungan keluar masuk kapal dalam dan luar negeri harus dilakukan dengan seksama dan terekam secara baik. Back Propagation merupakan simulasi buatan yang dibuat berdasarkan system kerja jaringan syaraf tiruan. Simulasi ini meniru data input yang dimasukkan sehingga menghasilkan data output yang mendekati hasil dari data input. Simulasi ini juga memiliki kecanggihan berupa menirukan data range yang berada diantara data input. Sehingga memudahkan dalam memprediksi data yang tidak ada didalam data input. Data kunjungan kapal dalam dan luar negeri diambil dari data Badan Pusat Statistik Sumatera Selatan dari tahun 2019 sampai 2021. Hasil simulasi Back Propagation untuk data kunjungan dalam negeri yang menghasilkan eror terkecil 0,92% dengan trial epoch sebanyak 175693 dan mengalami eror data di 53%. untuk data kunjungan luar negeri yang menghasilkan eror terkeci 1,44% dengan trial epoch sebanyak 189367 dan mengalami eror data di 73%. Dapat disimpulkan bahwa simulasi Back Propagation mampu memprediksi data kunjungan kapal dalam dan luar negeri.
A prospective study on the role of immunotherapy in metastatic cancer patients at Combined Military Hospital Dhaka
Authors: M. Quadrat E. Elahi  
Published: March 2023

Background: Immunotherapy is a treatment that uses a person’s immune system to fight cancer. Immunotherapy can boost or change how the immune system works so it can find and attack cancer cells. Among several cancers, metastatic cancer causes high mortality, and immunotherapies are expected to be effective in the prevention and treatment of metastatic cancer patients. In Bangladesh, we do have not enough research-based information regarding the role of immunotherapy in treating metastatic cancer patients. This study aimed to assess the role of immunotherapy in treating metastatic cancer patients.
Methods: This prospective observational study was conducted in combined military hospital Dhaka, Bangladesh during the period from 26 March 2021 to 21 July 2022. In total 19 patients with metastatic cancer were enrolled in this study as study subjects. Proper written consent was taken from all the participants before data collection. Two (02) different outcomes were studied in this study; progression-free survival (PFS) and side effect percentages. A predesigned questionnaire was used in data collection. All data were processed, analyzed, and disseminated by using MS excel and SPSS version 23 program as per necessity.
Results: In using pembrolizumab, side effects, fatigue, nausea, and decreased appetite were found 43%, 22%, and 20% lesser respectively than chemotherapy which was noticeable. In using nivolumab, as a side effect, skin rash was found 66% lesser than chemotherapy. Besides this, itching, face swelling, and apnea was found 33% lesser. On the other hand, in using atezolizumab, as side effects, swelling of arms and constipation were found 66% lesser, and itching, as well as apnea, was found 33% lesser than that in chemotherapy. At the 6-month follow-up we observed that in the nivolumab and atezolizumab treated groups 66% of cases survived separately whereas, in pembrolizumab treated group, 61% survived.
Conclusions: In this study in all treatment groups, side effects were found as lesser than that in using chemotherapy. No major complication of any patients was observed in this study. So, can conclude that immune checkpoint inhibitors (ICIs) are better choice for metastatic diseases and ICIs exert lesser side effects than conventional chemotherapies.
Accuracy of Shukla’s formula for depth of insertion of umbilical venous catheter
Authors: Vegesna Dedeepya  , Gudavalli Mounica  , N. L. Sravanthi  , Arigela Sumasree  , B. Vijaya Lakshmi  
Published: March 2023

Background: The use of umbilical venous catheter (UVC) is an essential part of neonatal care allowing delivery of intravenous fluids, nutrition, and medication. It is important to know the position of the UVC tip accurately at the first attempt to prevent complications and minimize handling. We aimed to determine the precision and accuracy of Shukla’s formula developed to guide UVC placement and to evaluate the probability of UVC placement at desired radiological markings using weight-based Shukla’s formula.
Methods: This study was carried out at NICU in NRI medical college, a tertiary care center in Chinakakani, Andhra Pradesh, India. A prospective observational study was done from December of 2021 to September 2022. With an aim to study the accuracy of Shukla's formula in assessing the depth of insertion of UVC, depth was calculated and position of the tip of the catheter confirmed by x-ray.
Results: We have taken 138 neonates in our NICU unit with mean gestational age of 33.91 wks. and with mean birth weight of 1.91 kg. Out of 138 infants 99 had a successful ideal UVC placement using Shukla's formula. In reference to gestational age out 83 newborns in gestational age between 32-36 weeks 62 had ideal placement of UVC. In reference to birth weight ideal position of the UVC was seen in 73% of newborns.
Conclusions: Shukla’s formula provided a reasonably accurate probability of achieving ideal UVC position in most of our babies: accurate in 72%.
A Model for Predicting Medical Solid Waste in Hilla City, Iraq
Authors: Fatlawi Suad Al , Al-Alwani Mustafa 
Published: March 2023

Introduction: To improve current practices and create the most effective healthcare waste treatment system, solid medical waste composition needs to be analyzed. This study aims to develop models to predict the rate of medical waste production in hospitals in Hilla city, Iraq. Predictive mode can be used to set standards, evaluate current methods for treating and disposing medical waste, and optimize healthcare solid waste management systems.
Materials and Methods: Predictive models and long-term data on the composition and rate of solid medical waste generation were developed using a longitudinal study design. A standardized questionnaire and weighted scale were used to measure solid medical waste generated from the five public hospitals. Statistics were used to create models predicting the amount of waste generated at each hospital.
Results: These models demonstrated a significant correlation between inpatient and outpatient numbers and waste generation. Different hospitals treat different numbers of inpatients and outpatients. Different models have been created based on various types of hospitals.
Conclusion: Linear rule-based models accurately represent the weights of variables, identify the sources and implications of solid medical waste, and control waste levels by using a variety of parameters. The research model can help in the development of an effective strategic plan for setting up a medical solid waste (MSW) management system.