bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Mutant-p53 for Cancer Treatment: Are We There Yet?
Authors: Lim Dhi Vya , Woo Wei Hwei , Lim Jing Xuan , Loh Xin Yee , Soh Hui Ting , Lim Seng Yung Adrian , Lee Zheng Yang , Yow Hui Yin , Hamzah Sharina Binti , Sellappans Renukha , Foo Jhi Biau 
Published: September 2023

Background:
Mutations in the TP53 gene are the most common among genetic alterations in human cancers, resulting in the formation of mutant p53 protein (mutp53). Mutp53 promotes proliferation, migration, invasion, and metastasis in cancer cells. Not only does the initiation of oncogenesis ensue due to mutp53, but resistance towards chemotherapy and radiotherapy in cancer cells also occurs. This review aims to summarise and discuss the oncogenesis of mutant p53 in cancer cells and introduce the various mutant p53 inhibitors currently being evaluated at the pre-clinical and clinical stages. Compounds that induce the wild-type conformation on the targeted p53 missense mutation, restore or enhance the DNA binding of mutant p53, and inhibit cancer cells' growth are highlighted. In addition, the progression and development of the mutant p53 inhibitors in clinical trials are updated.

Conclusion:
The progress of developing a cancer treatment that may successfully and efficiently target mutant p53 is on the verge of development. Mutant p53 proteins not only initiate oncogenesis but also cause resistance in cancer cells to certain chemo or radiotherapies, further endorse cancer cell survival and promote migration as well as metastasis of cancerous cells. With this regard, many mutant p53 inhibitors have been developed, some of which are currently being evaluated at the pre-clinical level and have been identified and discussed. To date, APR-246 is the most prominent one that has progressed to the Phase III clinical trial.
Comparison of Ussing Chamber and Caco-2 Model in Evaluation of
Intestinal Absorption Mechanism of Compounds from Different BCS
Classifications
Authors: Tian Dong , Yang Yingxin , Zhang Huiying , Du Hongwen , Zhou Hongyu , Wang Tao 
Published: September 2023

Background:
Oral bioavailability (F), which is evaluated by permeability and sol-ubility, is one of the key parameters in drug discovery. Currently, Caco-2 and Ussing cham-ber are both used in the study of intestinal permeability of drugs at different stages of drug development. However, comparative research between the Ussing chamber and Caco-2 for predicting the intestinal availability data (Fa×Fg) in humans has not been reported.

Methods:
In the present study, we evaluated the permeability of 22 drugs in rat intestines by Ussing chamber and compared them with the reported permeability data from Caco-2. In addition, the active transport of gabapentin was evaluated by Ussing Chamber.

Results:
Intestine segments were selected by corresponding absorption site for Ussing cham-ber analysis. BCS Class I and II compounds were more absorbed in the duodenum and jeju-num, and Class III and IV compounds were more absorbed in the ileum. Papp values in the Caco-2 model were moderately correlated with human Fa×Fg (R2=0.722), and the Papp of the rat in the Ussing chamber revealed a better correlation with human Fa×Fg (R2=0.952). In addi-tion, we also used the Ussing chamber to identify the transporter of gabapentin, and the re-sults showed that the active absorption of gabapentin was related to LAT1.

Conclusion:
Ussing chamber combined with rat intestinal tissue would be a significant tool for predicting the intestinal absorption and metabolism of compounds with diverse physio-chemical characteristics.
GIS-based Spatial Analysis of the Evolution of Residential Developments; A Case-study of Sulaimani city, Iraq
Authors: Mohammed Shaimaa Sarwar , Rasul Hoshyar Qadir , Mohammed Hussein Darweesh  
Published: September 2023

This research is aimed at visualizing the historical evolution of residential landuse development of Sulaimani city based on GIS spatial analysis with the input of all of the relevant available data in various formats in order to determine the form of the city according to morphological classifications discussed in the literature of urban planning. Essentially, following the collection of data, processing, review of relevant literature and applied methods, this study draws a timeline for the spatial evolution of the city of Sulaimani in addition to constricting a spatial grid for morphological comparison of different growth stages and analysis on multiple aspects. Moreover, a number of criteria were established to evaluate spatial patterns based on published theories in the field of landuse urban planning. These indicators were formulated in a questionnaire survey and determined the main aspects of the city through visualizing the process of historical evolution up to modern date. Finally, the study presents transformations and addresses current issues, as well as recommends a number of possible solutions for residential landuse development in the city of Sulaimani.
Investigation of the Effect of Needle Diameter and the Solution Flow Rate on Fiber Morphology in the Electrospinning Method
Authors: Gündüz Gonca Şimşek 
Published: September 2023

Abstract
In the study, the morphological properties of polyacrylonitrile (PAN) fibers produced by electrospinning at different needle diameters and solution flow rates were investigated. For this purpose, 20G and 22G diameter needles were used. The fibres were produced at flow rates of 0.5 ml/hr, 1 ml/hr and 1.5 ml/hr. Scanning electron microscopy (SEM) was used to measure nanofiber diameters. Statistical analyzes were made with the help of the SPSS program. It was observed that finer fibers were obtained as the needle diameter decreased. As the solution flow rate increased, thicker fibers were obtained. In addition, it was observed that the needle diameter and flow rate affect the fiber arrangement and interfiber spacing.
Board Composition and Non-Performing Loans among Commercial Banks in Tanzania
Authors: Budotela George , Mmari Goodluck , Towo Nathaniel 
Published: September 2023

Objective – This paper investigates the effect of board composition on non-performing loans (NPLs) for a sample of 31 commercial banks in Tanzania.Design/methodology – A quantitative study methodology was employed using annual data covering the period of 2011-2020. The authors used a one-step generalised method of moments (GMM) approach to estimate the effect of board composition on the percentage growth of NPLs in Tanzania.Results – The paper concludes that the number of board members with financial expertise, the board size, the audit committee, and the presence of female directors significantly negatively impact the bank’s NPLs and hence aid in lowering the bank’s NPLs. In contrast, an increase in board size, lagged NPLs, credit committees, independent directors, board meetings, and advances in deposit ratio significantly increases the level of NPLs, which is consistent with the agency theory.Research Limitations/Implications – Inconsistencies in the reported variables from various databases during the study and afterwards, as well as a lack of data for some banks in specific years. Shareholders should actively establish good corporate governance in the commercial banks (CBs) they own to reduce NPLs at an acceptable rate of less than 5%. Also, the Central Banks of Tanzania should encourage CBs to implement effective corporate governance practices by enacting rules and regulations to reduce NPLs. To minimize loan losses, authorities should impose micro-prudential supervision on commercial banks’ lending behavior. Novelty/Originality – The paper includes bank size and ownership using a one-step difference and one-step system (GMM) approach to measure the effect, which is usually not the case with most studies.
Does Cultural Pluralism Matter? Views from Experts Involved in the Production of Accounting Textbooks
Authors: Irsyadillah Irsyadillah , Raihani Raihani , Zulfadhli Zulfadhli , Lasyoud Alhashmi Aboubaker 
Published: September 2023

Objective –The paper seeks to evaluate the perceptions and attitudes of individuals involved in the production of accounting textbooks about providing cultural pluralism in the textbooks.Methodology –This paper used semi-structured interviews with key actors of accounting textbook production, including translators, independent reviewers, adaptors, authors and commissioning editors. With one exception, all interviewees are also academics at universities. Results –The paper finds that accounting textbooks are cultural and political artifacts that reflect the the cultural, political, and ideological viewpoints of the powerful groups in the world. In other words, the textbook contents are the results of power domination. They have used accounting textbooks as powerful educational media to homogenise cultural and ethical values of accounting and accounting education to be solely based on Anglo-American capitalism. This has greatly affected the professionals involved in the textbook production. Therefore, it is not an urgent matter for them to incorporate diversity of perspectives into accounting textbooks used in Indonesia.Novelty/Originality –Although accounting research has explored the issues of accounting textbooks, such as the readability, price, selection, and use, studies that consider the political and cultural role of accounting textbooks especially from the perspective of individual involved in the textbook production are still scant. In particular, there is no research in Indonesia that presents the views of people who produce accounting textbooks regarding the content of their textbooks.
Company Size and Growth on Profitability: A Comparative Study in 5 ASEAN Countries
Authors: Santoso David , Hersugondo Hersugondo 
Published: September 2023

Objective –This study investigates the correlation between a firm's size and its growth with respect to profitability. It subsequently incorporates various firm-specific variables, including leverage and asset tangibility, as well as macroeconomic indicators.Design/Methodology –Employing a quantitative research approach, this study utilizes annual data spanning the years 2017 to 2021. The research focuses on listed companies within the ASEAN region, namely Indonesia, the Philippines, Malaysia, Vietnam, and Singapore. The primary data sources comprise the Bloomberg and COMPUSTAT Global databases. Using the fixed effect model, the study includes a total of 145 listed companies, resulting in 725 firm-year observations.Results –This study found that there is evidence of an insignificant negative relationship between size and profitability, while the relationship between growth and profitability is found to be positive and significant. This suggests that the phenomenon of economies of scale is still in place, but in the long run it might be replaced by the diseconomies of scale.Research limitations/implications – The study contributes to a nuanced understanding of relationships between variables within each country. However, the study does not use all companies from each respective country. Novelty/Originality –This study employs a unique methodology by drawing samples from five distinct ASEAN countries. It conducts an integrated analysis encompassing both a collective examination and individual assessments of these countries. By adopting such a comprehensive strategy, this research aims to provide a more holistic perspective on the intricate relationships under investigation.
Domestic Effluent Treated for the Cultivation of Anthurium (Anthurium Andraeanum Lind.)
Authors: Barreto Karoline Santos Gonçalves , Matias Maria Iraildes de Almeida Silva , Nogueira Narjara Walessa , De Freitas Rômulo Magno Oliveira 
Published: September 2023

Purpose: The objective of this research was to evaluate the growth and production of anthurium (Anthurium andraeanum Lind.) irrigated with dilutions of treated domestic effluent (EDT), aiming to reduce the use of water and recycle the nutrients present in the effluent.

Theoretical framework: Faced with the scarcity and irregularity of rainfall in the Recôncavo da Bahia, it emphasizes the need and urgency in the search for alternative sources of water for irrigation, such as wastewater, with the potential to supply the water and nutritional demands of plants, especially those with less restriction, like ornamentals.

Method/design/approach: The experimental design was completely randomized, using five dilutions of EDT (0, 25, 50, 75 and 100%) in drinking water, with four replications. Plant height, number of leaves, leaf area, number of flowers and shoot dry mass were evaluated.

Results and conclusion: Plants irrigated with EDT dilutions and fertilized with 50% of the recommended nitrogen and potassium showed growth and production similar to plants irrigated with water supply and fertilized with 100% of the recommended mineral fertilizer, which allows recommending the use of EDT for irrigation of anthurium with 50% reduction of mineral fertilization.

Research implications: The results obtained reinforce the importance of taking advantage of the nutrient content present in the effluent, with the possibility of partially replacing mineral fertilizers, favoring savings in quality water and mineral fertilizers.

Originality/value: Savings of good quality water and mineral fertilizers, in addition to providing a safe destination for the effluent.
Communicating the Message Analysis on Tiktok @Huseinjafar to Maintain Interfaith Tolerance
Authors: Wahyudin Aep 
Published: September 2023

Tiktok has become one of the most popular social media for many Indonesian young millennials. They seek the content at Tiktok mostly for their daily references. Husein Ja’far Al Hadar, a trending moslem scholar utilized Tiktok to deliver the message of inter religious dialogue. We analyzed one short video content using semantic method on Tiktok @huseinjafar which only contained the conversation among Islam, Christian and Buddhist. They talked about their perspectives on tolerance. The finding shown that the harmonious interreligious dialogue could bring the mutual understating when it communicated in peaceful way. The constructive communication process of their dialogue in the video brought the message of living in harmony and respecting each other toward the differences. Tiktok @huseinjafar wanted to deliver the true message of human values by worshiping God and the loving all mankind to shape harmonious interreligious environment.
Keywords:, Communicating, Tolerance, Human Values, Tiktok
Profile of Patients with Alcohol Dependence admitted to a Drug De-addiction Center in a Tertiary Care Hospital
Authors: Dutta Atreyee , Nayek Sandipan , Deka Bikashita 
Published: September 2023

Objective
To examine the profile of patients admitted to a drug de-addiction center of a tertiary care center or hospital with alcohol dependence.

Material and Methods
The study was held in the Department of Psychiatry, Assam Medical College and Hospital, Dibrugarh, Assam during the period from August 2020 to September 2021. 120 patients who fulfilled the criteria for alcohol dependence according to ICD-10 were included. Alcohol Use Disorder Identification Test (AUDIT) and Michigan Alcoholism Screening Test (MAST) were applied.

Results
Around 13.3% of the study participants started drinking alcohol at the age of 15 years. The average age at which the patients initiated drinking alcohol was 24.02 ± 7.19 years, and patients who had started drinking at an early age became dependent within 15 years of regular drinking. The most common cause of initiation of drinking was found to be curiosity, peer pressure, and familial disharmony (68.8%). Most of the patients (80%) were from the lower socio-economic class, educated till middle school, and majority (80.9%) of the participants had an AUDIT score of >20 indicating alcohol dependence.

Conclusion
Alcohol use is seen to begin at a young age (about 15 years), primarily in individuals with less education and in rural communities of this region of the state. Hence, public awareness campaigns and school-based educational initiatives should be undertaken.
A case of temporary occlusion of donor artery after secondary generalized seizure in a patient with superficial temporal artery-middle cerebral artery bypass
Authors: Tsukada Tsuyoshi , Masuoka Toru , Kubo Michiya 
Published: September 2023

Background:
To prevent stroke recurrence, a superficial temporal artery-middle cerebral artery (STA–MCA) bypass for atherosclerotic cerebrovascular occlusive disease is performed. Post stroke epilepsy is known as serious sequelae of stroke. Herein, we present a case of a 60-year-old man who underwent STA–MCA bypass for the prevention of stroke recurrence; however, the donor artery was deemed to be temporally occluded secondary to generalized seizure.

Case Description:
A 60-year-old man was referred to our hospital with a diagnosis of the left cervical internal carotid artery occlusion presenting with mild aphasia and right hemiparesis. He underwent STA–MCA bypass to prevent the recurrence of stroke 1 month after the onset of symptoms. On postoperative day 7, patency of the donor artery was confirmed on magnetic resonance imaging (MRI), and no complications were noted. However, on postoperative day 14, he presented with a secondary generalized seizure. MRI was immediately performed and the donor artery was not patent with no new lesions. Several hours thereafter, the blood flow of the donor artery was confirmed using pulse Doppler; however, during mouth opening, the flow of the donor artery decreased. Computed tomography-angiography confirmed donor artery patency. An encephalogram was conducted and revealed a focal epilepsy which was compatible with stroke on MRI.

Conclusion:
Post stroke epilepsy caused an unintended and forced mouth opening which led to a temporary occlusion of the donor artery after STA–MCA bypass. Thus, this complication should be recognized, and seizures should be prevented through the administration of prophylactic anti-seizure medication based on risk stratification assessment of post stroke epilepsy.
LIPID PEROXIDATION IN INDIVIDUALS WITH POST-CORONAVIRUS SYNDROME
Authors: Румянцев Е.К. , Николаев В.М. , Софронова С.И. , Григорьева А.А. , Чирикова Н.К. 
Published: September 2023

Наши результаты свидетельствуют о том, что с увеличением степени тяжести течения заболевания COVID-19, увеличивается количество жалоб на повышения артериального давления. Интенсивность свободнорадикального окисления липидов даже через 8 месяцев с момента выписки из стационара была выше у переболевших с более тяжелым поражением легких.
Our results suggest that as the severity of the COVID-19 disease progresses, the number of complaints of increased blood pressure increases. The intensity of free radical lipid oxidation, even after 8 months from the moment of discharge from the hospital, was higher in those who had recovered from the disease with more severe lung damage.
THE POSSIBILITY OF USING HYDROGELS IN HYDROMETALLURGY FOR THE EXTRACTION OF HEAVY METALS (BRIEF REVIEW)
Authors: Очеретяна С.О. 
Published: September 2023

Гидрогели имеют множество полезных свойств и широко используются в различных промышленных отраслях, включая медицину, сельское хозяйство и косметологию. Однако, их адсорбционные свойства делают их особенно привлекательными в гидрометаллургии, где их способность извлекать тяжелые металлы и другие загрязняющие вещества может быть полезной для защиты окружающей среды и извлечения ценных ресурсов из отвалов. Существует два основных типа гидрогелей: синтетические и природные. Природные гидрогели, такие как агар или желатин и карбоксиметилцеллюлоза, считаются менее вредными для окружающей среды и более биоразлагаемыми. Однако, синтетические гидрогели имеют более высокую устойчивость к механическому износу и могут иметь более высокую адсорбционную способность. Анализ литературных данных показывает, что на данный момент гидрогели и их модификации привлекают значительный интерес, особенно в области извлечения тяжелых металлов. Ниже приведен краткий обзор некоторых работ и аспектов, связанных с этой областью.
Hydrogels have many useful properties and are widely used in various industries, including medicine, agriculture and cosmetology. However, their adsorption properties make them especially attractive in hydrometallurgy, where their ability to remove heavy metals and other contaminants can be beneficial to protect the environment and recover valuable resources from dumps. There are two main types of hydrogels: synthetic and natural. Natural hydrogels such as agar or gelatin and carboxymethylcellulose are considered less environmentally harmful and more biodegradable. However, synthetic hydrogels have higher resistance to mechanical wear and may have higher adsorption capacity. An analysis of the literature data shows that hydrogels and their modifications are currently attracting considerable interest, especially in the field of heavy metal extraction. Below is a brief overview of some of the work and aspects related to this area.
STUDY OF ALIPHATIC HYDROCARBONS IN THE THERMOHYDROLYSIS PRODUCTS OF SAPROPELITE AND BROWN COALSBY CHROMATO-MASS SPECTROMETRY
Authors: Рокосов Ю.В. , Рокосова Н.Н. , Горюнова П.В. 
Published: September 2023

С помощью метода хромато-масс-спектрометрии, с учетом закономерностей фрагментации соединений при ионизации электронным ударом, проведено сравнительное исследование состава алифатических углеводородов ближнего диапазона распределения (< n-C18) в продуктах термогидролиза сапропелитов Кушмурунского месторождения Казахстана, бурых углей Кайчакского месторождения (Кемеровская область) и Кангаласского месторождения (Якутия). Проведен сравнительный анализ данных о групповом и индивидуальном составе алифатических углеводородных фракций. Индивидуальные алифатические соединения и их гомологи идентифицировали по масс-спектрам с использованием базы данных NIST-11 и информационно-поисковых программ AMDIS и ChemStation.
Using the method of gas chromatography-mass spectrometry, taking into account the patterns of fragmentation of compounds during ionization by electron impact, a comparative study of the composition of aliphatic hydrocarbons in the near distribution range (< n-C18) in the products of thermal hydrolysis of sapropelites from the Kushm-urunsky deposit in Kazakhstan, brown coals from the Kaichaksky deposit (Kemerovo region) was carried out and the Kangalassky field (Yakutia). A comparative analysis of data on the group and individual composition of aliphatic hydrocarbon fractions has been carried out. Individual aliphatic compounds and their homologues were identified by mass spectra using the NIST-11 database and AMDIS and ChemStation information retrieval programs.