bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins
Authors: Wang Junkai , Saltzman Alexander B. , Jaehnig Eric J. , Lei Jonathan T. , Malovannaya Anna , Holt Matthew V. , Young Meggie N. , Rimawi Mothaffar F. , Ademuyiwa Foluso O. , Anurag Meenakshi , Kim Beom-Jun , Ellis Matthew J. 
Published: July 2023

Triple-negative breast cancer (TNBC) constitutes 10%–15% of all breast tumors. The current standard of care is multiagent chemotherapy, which is effective in only a subset of patients. The original objective of this study was to deploy a mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) to identify kinases elevated in non-pCR (pathologic complete response) cases for therapeutic targeting. Frozen optimal cutting temperature compound–embedded core needle biopsies were obtained from 43 patients with TNBC before docetaxel- and carboplatin-based neoadjuvant chemotherapy. KIPA was applied to the native tumor lysates that were extracted from samples with high tumor content. Seven percent of all identified proteins were kinases, and none were significantly associated with lack of pCR. However, among a large population of “off-target” purine-binding proteins (PBP) identified, seven were enriched in pCR-associated samples (P &lt; 0.01). In orthogonal mRNA-based TNBC datasets, this seven-gene “PBP signature” was associated with chemotherapy sensitivity and favorable clinical outcomes. Functional annotation demonstrated IFN gamma response, nuclear import of DNA repair proteins, and cell death associations. Comparisons with standard tandem mass tagged–based discovery proteomics performed on the same samples demonstrated that KIPA-nominated pCR biomarkers were unique to the platform. KIPA is a novel biomarker discovery tool with unexpected utility for the identification of PBPs related to cytotoxic drug response. The PBP signature has the potential to contribute to clinical trials designed to either escalate or de-escalate therapy based on pCR probability.

Significance:
The identification of pretreatment predictive biomarkers for pCR in response to neoadjuvant chemotherapy would advance precision treatment for TNBC. To complement standard proteogenomic discovery profiling, a KIPA was deployed and unexpectedly identified a seven-member non-kinase PBP pCR-associated signature. Individual members served diverse pathways including IFN gamma response, nuclear import of DNA repair proteins, and cell death.
4. Julie Jeanne Éléonore de Lespinasse
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
7. Stéphanie Félicité, Marquise de Sillery, Comtesse de Genlis
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
10. Marie Louise Élisabeth Vigée Le Brun
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
12. Sophie de Grouchy or Sophie de Condorcet
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
16. Henriette Lucie Dillon, Marquise de La Tour-du-Pin Gouvernet
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
17. Marie Sophie Risteau Cottin
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
19. Claire Louisa Rose Bonne, Duchesse de Duras
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
28. Marie Catherine Sophie de Flavigny, Comtesse d’Agoult [Daniel Stern]
Authors: Isbell John Claiborne 
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.
Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.
This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
Is violence against men a problem in Sri Lanka?
Authors: Jayaratne Sashini , Wijewardena Kumudu 
Published: July 2023

Background: Gender-based violence (GBV) among men is a universally present phenomenon that is mostly unacknowledged. The relative lack of research in this area leads to a deficiency of evidence ascribing due recognition to GBV among men. This, in turn, leads to not identifying it as a social problem, hence, poor development of resources for victims as well as poor help-seeking behaviour patterns are prevalent, especially in Southeast Asia. Aims: We aimed to determine the prevalence of GBV among men in Colombo, Sri Lanka. Method: A descriptive cross-sectional analytical community survey was conducted to explore GBV against 1280 Sinhala-speaking men, selected using a multistage cluster sampling method in Colombo district, Sri Lanka. The GBV among men questionnaire (GBVMQ) was developed and culturally validated. A multiple logistic regression model was developed and nine correlates of GBV were identified and adjusted odds ratios estimated. Results: The prevalence of GBV was 35.8% (95% CI 33.1 -38.6). The prevalence of Verbal GBV was 34.7% (95% CI 32.1 -37.5). Childhood sexual abuse was 7.6% (95% CI 6.2 -9.2). Being subjected to ridicule as cowardly or unmanly (AOR = 25.3, 95% CI 5.58 -114.7, P<0.0010), Childhood sexual abuse (AOR = 4.4, 95% CI 1.73 -11.09, P = 0.002) showed positive associations with statistical significance. Conclusion: The results highlight the importance of having services for men as well as women. Enabling inclusiveness of men in mandates of state and private institutions catering for GBV would be a strategy in moving forward for Sri Lanka.
Mitigation of airborne transmission of COVID virus between occupants in a confined room with an air purifier
Authors: Wang Chenhua , Li Chengjun , Yu Chuck W , Wang Hanqing 
Published: July 2023

This study evaluated the effect of ventilation rate and air supply angle of an air purifier using computational fluid dynamics to determine the dispersion of airborne COVID virus exhaled by an infected person. The risk of infection for an occupant was determined based on the virus concentration in the active area and accumulated particle dose within the breathing zone by varying the ventilation parameters. The air purifier was found to provide a local dilution and would block the development of an expiratory jet for a short time to reduce transmission risk. Compared to the case without an air purifier, the maximum reductions were 94.27% in the accumulated dose and 53.2% in the particle count concentration. In the breathing area, the larger air supply angle (90° > 60° > 30°) is better when the ventilation rate was 27.0 m3/h and 40.5 m3/h. Otherwise, 60° air supply angle is preferable where the ventilation rate was 54.0 m3/h. Assessing the results with the grey relational analysis revealed that the relational degree for particle count concentration was greater by varying the ventilation rate than by varying the air supply angle. However, the relational degree according to the accumulated dose was greater by varying the air supply angle than by increasing the ventilation rate. These findings may provide an important control strategy to effectively mitigate the risk of infection in a confined room by using an air purifier.
Preparation and characterization of graphene antibacterial phase change energy storage viscose fibers
Authors: Zhao Zhou , Du Shichang , Li Bei , Li Yan , Wang Jinmei , Ren Jun 
Published: July 2023

In this work, viscose fiber with antibacterial and phase change energy storage was made by microcapsule technology and wet spinning. Graphene oxide was used to enhance the thermal conductivity and antimicrobial properties. The heat preservation performance of graphene antibacterial phase change energy storage viscose fiber was determined by flat type fabric temperature protector and differential scanning calorimetry. The result of heat preservation test shows that the fiber has a good heat preservation property The antibacterial property, far-infrared property, mechanical properties, and the structures were also characterized. The enthalpy of exothermic & endothermic phase transition reached about 10 mJ/mg. According to the result of antibacterial test, the fiber had good antibacterial properties. The distribution of phase change microcapsules and graphene in fibers was analyzed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The strength and elongation of antibacterial phase change viscose fiber were found suitable for underwear garments fabrics and filling storage sheet. Combined with the electron microscope photograph and strength test results, the addition of graphene and phase change microcapsules has little effect on the mechanical properties of fibers, and can be used for industrial production.
The Development and Integration of a Safety Officer Role to Facilitate Prevention of COVID-19 Virus Transmission in an Adult Inpatient Rehabilitation Setting Using Collaborative Change Leadership Methodology
Authors: Donaghy Siobhan , Shaffer Jennifer , Schneider Susan 
Published: July 2023

Background: With the onset of the COVID-19 pandemic, a large urban academic hospital responded by creating the temporary role of a “Safety Officer (SO).” The key task of the SO role was to supervise staff donning and doffing personal protective equipment (PPE) and provide real-time feedback on their performance. The support for safe donning and doffing would contribute to staff well-being by reducing their fear of infection transmission. Methods: A Collaborative Change Leadership (CCL) approach was used to facilitate the development, implementation, and evaluation of the role. This included an iterative feedback process with clinicians and safety officers to continually refine the role. Findings: Feedback indicated value in the initiative as increasing staff confidence about preventing virus transmission, as well as their sense of safety at work. Areas for future improvement included additional communication strategies for interprofessional teams and external partners, as well as planning around logistics to better support the safety officers in performing this new, temporary role. Conclusions/Application to Practice: The Safety Officer role was able to help alleviate concerns regarding potential infection transmission and contribute positively to staff well-being.
Expected Health Benefits of SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Older Adults
Authors: Dadwani Rahul S. , Wan Wen , Skandari M. Reza , Huang Elbert S. 
Published: July 2023

Background. Older and sicker adults with type 2 diabetes (T2D) were underrepresented in randomized trials of glucagon-like peptide 1 receptor-agonist (GLP1RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2I), and thus, health benefits are uncertain in this population. Objective. To assess the impact of age, health status, and life expectancy in older adults with T2D on health benefits of GLP1RA and SGLT2I. Design. We used the United Kingdom Prospective Diabetes Study (UKPDS) model to simulate lifetime health outcomes. We calibrated the UKPDS model to improve mortality prediction in older adults using a common geriatric prognostic index. Participants. National Health and Nutrition Examination Survey 2013–2018 participants 65 y and older with T2D, eligible for GLP1RA or SGLT2I according to American Diabetes Association guidelines. Interventions. GLP1RA or SGLT2I use versus no additional medication. Main Measures. Lifetime complications and weighted life-years (LYs) and quality-adjusted life-years (QALYs) across overall treatment arms and life expectancies. Key Results. The overall older adult population was predicted to experience significant health benefits from GLP1RA (+0.29 LY [95% confidence interval: 0.27, 0.31], +0.15 QALYs [0.14, 0.16]) and SGLT2I (+0.26 LY [0.24, 0.28], +0.13 QALYs [0.12, 0.14]) as compared with no added medication. However, expected benefits declined in subgroups with shorter life expectancies. Participants with <4 y of life expectancy had minimal gains of <0.05 LY and <0.03 QALYs from added medication. Accounting for injection-related disutility, GLP1RA use reduced QALYs (−0.03 QALYs [−0.04, −0.02]). Conclusions. While GLP1RA and SGLT2I have substantial health benefits for many older adults with type 2 diabetes, benefits are not clinically significant in patients with <4 y of life expectancy. Life expectancy and patient preferences are important considerations when prescribing newer diabetes medications. Highlights On average, older adults benefit significantly from SGLT2I and GLP1RA use. However, the benefits of these drugs are not clinically significant among older patients with life expectancy less than 4 y. There is potential harm in injectable GLP1RA use in the oldest categories of adults with type 2 diabetes. Heterogeneity in life expectancy and patient preferences for injectable versus oral medications are important to consider when prescribing newer diabetes medications