bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of severe tricuspid regurgitation induced by permanent pacemaker lead: Transcatheter tricuspid valve replacement with the guidance of 3-dimensional printing
Authors: Mao Yu , Liu Yang , Meng Xin , Ma Yanyan , Li Lanlan , Zhai Mengen , Jin Ping , Lu Fanglin , Yang Jian 
Published: March 2023

BackgroundLead-induced tricuspid regurgitation is one of the complications after permanent pacemaker implantation (PPI) and refers to tricuspid regurgitation (TR) caused by the lead in the right ventricle (RV).ObjectivesTo study the clinical characteristics of severe TR after PPI and the effect of transcatheter tricuspid valve replacement (TTVR) with the guidance of 3-dimensional (3D) printing.MethodsThis study was a single-center, descriptive study. Six patients with severe TR after PPI were enrolled in Xijing Hospital from January 2020 to May 2020. Before TTVR, the 3D printed tricuspid valve (TV) model was used for evaluation in the bench test. LuX-Valve was implanted under the guidance of TEE and x-ray fluoroscopy, and all patients underwent transatrial access. Six patients’ data were collected at baseline, before discharge, and 6 months, 1 year and 2 years after TTVR.ResultsThe LuX-Valve was successfully implanted in 6 patients, TR was significantly reduced to ≤2+, and no deaths or cardiopulmonary bypass occurred during procedures. Three cases were caused by TV expansion: Patient #4 had TR caused by lead adhesion to TV, Patient #2 had TR caused by lead winding, and Patient #6 had TR caused by lead impingement on TV. During the 2-year follow-up, TTE revealed that 5 patients had no/trace regurgitation, and one patient (Patient #5) had mild regurgitation. All 6 patients (100.0%) reached primary endpoints.ConclusionTTVR guided by 3D printing is safe and effective in the treatment of severe TR associated with permanent pacemaker lead, providing prospects and possibilities for the precise treatment of TV-related diseases.Clinical Trial Registration: ClinicalTrials.gov Protocol Registration System (NCT02917980).
Critical area identification and dynamic process simulation for landslide hazard chain formation in the upstream Jinsha River
Authors: Song Yixian , Deng Hongyan , Tang Chenxiao , Li Bokai 
Published: March 2023

The upper reaches of the Jinsha River, with their complex terrain and active tectonic movements, are vulnerable to landslide-induced hazard chain events, which endanger the safety of residents and infrastructure construction. Based on the analysis of the development background of the hazard chain in the upstream area of the Jinsha River, five factors, including the lithology, distance to faults, distance to rivers, peak ground acceleration, and slope degree, were selected to identify the critical landslide-prone areas. Principal component and grey correlation analyses were then conducted to determine the contributions of these different factors. Based on ArcGIS, the study zone was categorized into five classes of landslide susceptibility: very high, high, moderate, low, and very low. The identification of the critical target areas for landslide hazard chain formation showed satisfactory accuracy. The very high- and high-susceptibility areas are concentrated along the Jinsha River. The dynamic process of a typical landslide in a very high-susceptibility area was numerically simulated using OpenLISEM. The high-precision Baige landslide data of the study area were used to calibrate the practicality of the input mass parameters, including cohesion, internal friction angle, D50, and D90. The movement and accumulation processes of a typical landslide were then numerically simulated with the verified data. The entire landslide accumulation covers an area of 0.45 km2, with a length of 1,600 m and a width of 270 m. Thus, the OpenLISEM model, which combines mass, topography, and landcover parameters, is feasible for the numerical simulation of landslide dynamic processes. The prediction of the dynamic processes and accumulation morphology of landslides can provide a reference for the formation processes and mechanisms of the landslide-induced hazard chain in the upper Jinsha River.
Altered ureido protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men
Authors: Roy Rosa , Lorca Cristina , Mulet María , Sánchez Milán José Antonio , Baratas Alejandro , de la Casa Moisés , Espinet Carme , Serra Aida , Gallart-Palau Xavier 
Published: March 2023

IntroductionExtracellular vesicles (EVs) have been recognized as key players in numerous physiological functions. These vesicles alter their compositions attuned to the health and disease states of the organism. In men, significant changes in the proteomic composition(s) of seminal plasma EVs (sEVs) have already been found to be related to infertility.MethodsMethods: In this study, we analyze the posttranslational configuration of sEV proteomes from normozoospermic (NZ) men and non-normozoospermic (non-NZ) men diagnosed with teratozoospermia and/or asthenozoospermia by unbiased, discovery-driven proteomics and advanced bioinformatics, specifically focusing on citrulline (Cit) and homocitrulline (hCit) posttranscriptional residues, both considered product of ureido protein modifications.Results and discussionSignificant increase in the proteome-wide cumulative presence of hCit together with downregulation of Cit in specific proteins related to decisive molecular functions have been encountered in sEVs of non-NZ subjects. These findings identify novel culprits with a higher chance of affecting fundamental aspects of sperm functional quality and define potential specific diagnostic and prognostic non-invasive markers for male infertility.
Optimization of the offshore wind power grid-connected structure based on an improved genetic algorithm
Authors: Li Haibo , Jiang Keteng , Lu Zongxiang , Hou Junhao , Xu Sixuan , Qi Wanchun , Cai Hui 
Published: March 2023

Large-scale offshore wind power generation has become one of the research hotspots in the development of new energy in the world. However, the planning of far-reaching offshore wind power is faced with many technical difficulties, such as the need to consider the optimization of line transmission capacity caused by the truncation effect in combination with the wind power output probability, and solve the problem that traditional algorithms cannot solve the dynamic programming problem, and the greedy algorithm for solving the dynamic programming problem cannot solve the global optimal solution. Therefore, in order to solve the above problems, based on the full life cycle (FLC) investment calculation of the collecting and transmission system, the topology optimization model of the offshore wind power system is established. In addition, in order to solve the grid-connection problem of offshore wind farms, an improved topology optimization algorithm based on greedy idea is proposed. The optimization results show that the critical values of economic transmission distance of HVAC, FFTS and HVDC are usually 50 km and 170 km respectively. Finally, the collection scheme of the wind farm cluster including three far-reaching offshore wind farms are analyzed, and the results show that the total cost of the optimized point-to-point scheme is reduced by 5.6% and 10.2% respectively compared with the star topology and the circular collection topology, with significant economic benefits.
Matching for HLA-DR excluding diabetogenic HLA-DR3 and HLA-DR4 predicts insulin independence after pancreatic islet transplantation
Authors: Ballou Cassandra , Barton Franca , Payne Elizabeth H. , Berney Thierry , Villard Jean , Meier Raphael P. H. , Baidal David , Alejandro Rodolfo , Robien Mark , Eggerman Thomas L. , Kamoun Malek , Muller Yannick D. 
Published: March 2023

IntroductionIn pancreatic islet transplantation, the exact contribution of human leukocyte antigen (HLA) matching to graft survival remains unclear. Islets may be exposed to allogenic rejection but also the recurrence of type 1 diabetes (T1D). We evaluated the HLA-DR matching, including the impact of diabetogenic HLA-DR3 or HLA-DR4 matches.MethodsWe retrospectively examined the HLA profile in 965 transplant recipients and 2327 islet donors. The study population was obtained from patients enrolled in the Collaborative Islet Transplant Registry. We then identified 87 recipients who received a single-islet infusion. Islet-kidney recipients, 2nd islet infusion, and patients with missing data were excluded from the analysis (n=878).ResultsHLA-DR3 and HLA-DR4 were present in 29.7% and 32.6% of T1D recipients and 11.6% and 15.8% of the donors, respectively. We identified 52 T1D islet recipients mismatched for HLA-DR (group A), 11 with 1 or 2 HLA-DR-matches but excluding HLA-DR3 and HLA- DR4 (group B), and 24 matched for HLA-DR3 or HLA-DR4 (group C). Insulin-independence was maintained in a significantly higher percentage of group B recipients from year one through five post-transplantation (p&lt;0.01). At five-year post-transplantation, 78% of group B was insulin-independent compared to 24% (group A) and 35% (group C). Insulin-independence correlated with significantly better glycemic control (HbA1c &lt;7%), fasting blood glucose, and reduced severe hypoglycemic events. Matching HLA-A-B-DR (≥3) independently of HLA- DR3 or HLA-DR4 matching did not improve graft survival.ConclusionThis study suggests that matching HLA-DR but excluding the diabetogenic HLA-DR3 and/or 4 is a significant predictor for long-term islet survival.
Longitudinal choroidal thickness changes among Chinese young adults with various refractive errors
Authors: Duan Fang , Chen Ziyan , Wang Zhenyu , Deng Jiayu , Yeo Anna C.H. , Yang Adeline , Drobe Björn , Wong Yee Ling , Chen Xiang 
Published: March 2023

PurposeTo determine the characteristics of longitudinal choroidal thickness (CT) and axial length (AL) changes in a group of Chinese young adults with various refractive errors.MethodsIn this 2 year prospective cohort study, a total of 291 (314 enrolled at baseline) Chinese medical freshmen aged 18 to 22 years (mean age, 18.7 ± 0.9 years) underwent eye examinations at baseline and follow-up visits, including cycloplegic refraction, ocular biometry measurements, and swept-source optical coherence tomography. Choroidal thickness measurements were performed at nine locations in the macular area.ResultsAt baseline, the CT and AL was significant differences among groups of emmetropia, mild to moderate myopia and high myopia. During a two-year period, there were significant differences found in the changes of the subfoveal CT (p &lt; 0.001) and parafoveal CT of 7 locations between emmetropia and mild to moderate myopia, and the changes of the subfoveal CT (p = 0.002) and parafoveal CT of 6 locations between emmetropia and high myopia. But there were no differences for AL and SE (p &gt; 0.05). The multivariable linear regression analysis showed that baseline subfoveal CT (per 1 μm) was a significant factor affecting the changes of subfoveal CT (p &lt; 0.001), whereas age, gender, and baseline AL were not significantly associated.ConclusionThe longitudinal change in CT varies with refractive errors in Chinese young adults aged 18 to 22 years over a two-year period. The changes of subfoveal CT were significantly associated with the baseline subfoveal CT, but not associated with baseline AL.
CovAID: Identification of factors associated with severe COVID-19 in patients with inflammatory rheumatism or autoimmune diseases
Authors: Chevalier Kevin , Genin Michaël , Jean Thomas Petit , Avouac Jerôme , Flipo Rene-Marc , Georgin-Lavialle Sophie , El Mahou Soumaya , Pertuiset Edouard , Pham Thao , Servettaz Amelie , Marotte Hubert , Domont Fanny , Chazerain Pascal , Devaux Mathilde , Mekinian Arsene , Sellam Jérémie , Fautrel Bruno , Rouzaud Diane , Ebstein Esther , Costedoat-Chalumeau Nathalie , Richez Christophe , Hachulla Eric , Mariette Xavier , Seror Raphaèle 
Published: March 2023

IntroductionAutoimmune/inflammatory rheumatic diseases (AIRDs) patients might be at-risk of severe COVID-19. However, whether this is linked to the disease or to its treatment is difficult to determine. This study aimed to identify factors associated with occurrence of severe COVID-19 in AIRD patients and to evaluate whether having an AIRD was associated with increased risk of severe COVID-19 or death.Materials and methodsTwo databases were analyzed: the EDS (Entrepôt des Données de Santé, Clinical Data Warehouse), including all patients followed in Paris university hospitals and the French multi-center COVID-19 cohort [French rheumatic and musculoskeletal diseases (RMD)]. First, in a combined analysis we compared patients with severe and non-severe COVID-19 to identify factors associated with severity. Then, we performed a propensity matched score case–control study within the EDS database to compare AIRD cases and non-AIRD controls.ResultsAmong 1,213 patients, 195 (16.1%) experienced severe COVID-19. In multivariate analysis, older age, interstitial lung disease (ILD), arterial hypertension, obesity, sarcoidosis, vasculitis, auto-inflammatory diseases, and treatment with corticosteroids or rituximab were associated with increased risk of severe COVID-19. Among 35,741 COVID-19 patients in EDS, 316 having AIRDs were compared to 1,264 Propensity score-matched controls. AIRD patients had a higher risk of severe COVID-19 [aOR = 1.43 (1.08–1.87), p = 0.01] but analysis restricted to rheumatoid arthritis and spondyloarthritis found no increased risk of severe COVID-19 [aOR = 1.11 (0.68–1.81)].ConclusionIn this multicenter study, we confirmed that AIRD patients treated with rituximab or corticosteroids and/or having vasculitis, auto-inflammatory disease, and sarcoidosis had increased risk of severe COVID-19. Also, AIRD patients had, overall, an increased risk of severe COVID-19 compares general population.
Antimicrobial activity of antidepressants on normal gut microbiota: Results of the in vitro study
Authors: Rukavishnikov Grigory , Leonova Lubov , Kasyanov Evgeny , Leonov Vadim , Neznanov Nikholay , Mazo Galina 
Published: March 2023

Currently, there is little published data on the effects of antidepressants on normal gut microbiota and the consequences of such effects on treatment outcomes.The aim of the study: was to evaluate the growth kinetics of normal human gut microorganisms with antidepressants most common in routine clinical practice.Materials and methods: Research objects were species of microorganisms representing normal gut microbiota: Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Candida albicans ATCC 24433, Bifidobacterium 791, Enterococcus faecalis ATCC 29212, Lactobacillus rhamnosus ATCC 53103. All microorganisms were cultivated in Schaedler broth (HiMedia) under aerobic/anaerobic conditions. The active substances of all studied antidepressants (fluvoxamine, fluoxetine, escitalopram, duloxetine, venlafaxine, mirtazapine) were extracted from ground preparations by dimethyl sulfoxide and centrifuged. Each solution of antidepressants was added to a Schaedler broth containing a certain microorganism’s strain and diluted to final concentrations—200 μg/ml, 500 μg/ml, and 700 μg/ml. For a quantitative assessment of the effect, the specific growth rates (μ, h-1) of microorganisms were calculated as the slope of the initial part of the growth curve in coordinates (lnA, t). To evaluate the antidepressant effects on representatives of the normal microbiota in vitro, the following parameters were chosen: specific growth rate and IC50.Results: All antidepressants had an inhibitory effect on the growth of all studied microorganisms. Fluvoxamine and venlafaxine had the least effect on the growth activity of all studied microorganisms. Fluoxetine showed a pronounced effect on growth activity against E. coli, E. feacalis, S. aureus, and the least effect against C. albicans. Escitalopram had a greater effect on the growth rate of E. coli, E. feacalis, B. bifidum, L. rhamnosus, and C. albicans, which puts it among the leaders in terms of its effect on the growth activity of the microorganisms we studied. Mirtazapine, according to the results of our experiment, showed the greatest activity against L. rhamnosus and C. albicans.Conclusions: Our results confirm the effects of antidepressants on the growth activity of the normal gut microbiota individual strains. Further study of the antimicrobial activity of antidepressants may become one of the new directions for optimizing the personalized therapy of patients with depression.
A nomogram for predicting the risk of poor prognosis in patients with poor-grade aneurysmal subarachnoid hemorrhage following microsurgical clipping
Authors: Zhou Zhaopeng , Liu Zhuanghua , Yang Hongqiao , Zhang Chunlei , Zhang Chenxu , Chen Junhui , Wang Yuhai 
Published: March 2023

ObjectiveAneurysmal subarachnoid hemorrhage (aSAH) is a common and potentially fatal cerebrovascular disease. Poor-grade aSAH (Hunt-Hess grades IV and V) accounts for 20–30% of patients with aSAH, with most patients having a poor prognosis. This study aimed to develop a stable nomogram model for predicting adverse outcomes at 6 months in patients with aSAH, and thus, aid in improving the prognosis.MethodThe clinical data and imaging findings of 150 patients with poor-grade aSAH treated with microsurgical clipping of intracranial aneurysms on admission from December 2015 to October 2021 were retrospectively analyzed. Least absolute shrinkage and selection operator (LASSO), logistic regression analyses, and a nomogram were used to develop the prognostic models. Receiver operating characteristic (ROC) curves and Hosmer–Lemeshow tests were used to assess discrimination and calibration. The bootstrap method (1,000 repetitions) was used for internal validation. Decision curve analysis (DCA) was performed to evaluate the clinical validity of the nomogram model.ResultLASSO regression analysis showed that age, Hunt-Hess grade, Glasgow Coma Scale (GCS), aneurysm size, and refractory hyperpyrexia were potential predictors for poor-grade aSAH. Logistic regression analyses revealed that age (OR: 1.107, 95% CI: 1.056–1.116, P &lt; 0.001), Hunt-Hess grade (OR: 8.832, 95% CI: 2.312–33.736, P = 0.001), aneurysm size (OR: 6.871, 95% CI: 1.907–24.754, P = 0.003) and refractory fever (OR: 3.610, 95% CI: 1.301–10.018, P &lt; 0.001) were independent predictors of poor outcome. The area under the ROC curve (AUC) was 0.909. The calibration curve and Hosmer–Lemeshow tests showed that the nomogram had good calibration ability. Furthermore, the DCA curve showed better clinical utilization of the nomogram.ConclusionThis study provides a reliable and valuable nomogram that can accurately predict the risk of poor prognosis in patients with poor-grade aSAH after microsurgical clipping. This tool is easy to use and can help physicians make appropriate clinical decisions to significantly improve patient prognosis.
Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients
Authors: Wang Meixia , Cheng Xiaoyu , Shi Qianru , Xu Bo , Hou Xiaoxia , Zhao Huimin , Gui Qian , Wu Guanhui , Dong Xiaofeng , Xu Qinrong , Shen Mingqiang , Cheng Qingzhang , Xue Shouru , Feng Hongxuan , Ding Zhiliang 
Published: March 2023

IntroductionAccumulating evidence shows that epilepsy is a disease caused by brain network dysfunction. This study explored changes in brain network structure in epilepsy patients based on graph analysis of diffusion tensor imaging data.MethodsThe brain structure networks of 42 healthy control individuals and 26 epilepsy patients were constructed. Using graph theory analysis, global and local network topology parameters of the brain structure network were calculated, and changes in global and local characteristics of the brain network in epilepsy patients were quantitatively analyzed.ResultsCompared with the healthy control group, the epilepsy patient group showed lower global efficiency, local efficiency, clustering coefficient, and a longer shortest path length. Both healthy control individuals and epilepsy patients showed small-world attributes, with no significant difference between groups. The epilepsy patient group showed lower nodal local efficiency and nodal clustering coefficient in the right olfactory cortex and right rectus and lower nodal degree centrality in the right olfactory cortex and the left paracentral lobular compared with the healthy control group. In addition, the epilepsy patient group showed a smaller fiber number of edges in specific regions of the frontal lobe, temporal lobe, and default mode network, indicating reduced connection strength.DiscussionEpilepsy patients exhibited lower global and local brain network properties as well as reduced white matter fiber connectivity in key brain regions. These findings further support the idea that epilepsy is a brain network disorder.
Association between vitamin K intake and depressive symptoms in US adults: Data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018
Authors: Zhang Yuyi , Tan Weiliang , Xi Xiaolan , Yang Hui , Zhang Ke , Li Shengnan , Chen Xuefen , Zuo Hui 
Published: March 2023

BackgroundThe relationship between vitamin intake and depression has attracted increasing attention. However, several studies examining such relationship among populations at different age groups have produced inconsistent findings. This study was aimed to investigate the cross-sectional association between vitamin K intake and depressive symptoms in US adults.MethodsWe used the data from a nationally representative sample of 11,687 adults from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES). Vitamin K intake was assessed by the 24-h dietary recall at the first day. Depressive symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ-9). Logistic regression and generalized additive model were used to examine the association between vitamin K intake and depressive symptoms.ResultsThe weighted prevalence of depressive symptoms was 10.2% (8.0% in men and 12.0% in women). We observed a significant inverse linear relationship between vitamin K intake and depressive symptoms in models adjusted for age, sex, race/ethnicity, marital status, educational status, family poverty income ratio (PIR), home status, body mass index (BMI), smoking status, physical activity, sleep disorders, hypertension, hyperlipidemia, and diabetes. The odds ratios (OR) (95% CI) for the highest compared with the lowest quartile of vitamin K intake was 0.68 (95% CI: 0.52, 0.89, p-trend &lt; 0.05). The association was similar in subgroups stratified by age, sex, race/ethnicity, marital status, educational status, PIR, home status, BMI, smoking status, physical activity, sleep disorders, hypertension, hyperlipidemia, and diabetes.ConclusionVitamin K intake was inversely and independently associated with the odds of depressive symptoms in the US adults. Prospective studies are warranted to confirm our findings.