bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total tumor volume as a predictor of survival in patients with multiple oligometastases treated with stereotactic ablative radiotherapy (SABR)
Authors: Franzese Ciro , Vernier Veronica , Franceschini Davide , Comito Tiziana , Navarria Pierina , Clerici Elena , Teriaca Maria Ausilia , Massaro Maria , Cristina Luciana , Marini Beatrice , Galdieri Carmela , Mancosu Pietro , Tomatis Stefano , Scorsetti Marta 
Published: April 2023

Abstract
Background: Delivering stereotactic ablative radiotherapy (SABR) in patients with multiple oligometastases represents a challenge for clinical and technical reasons. We aimed to evaluate the outcome of patients affected by multiple oligometastases treated with SABR and the impact of tumor volume on survival.
Materials and methods: We included all the patients treated with single course SABR for 3 to 5 extracranial oligometastases. All patients were treated with the volumetric modulated arc therapy (VMAT) technique with ablative intent. End-points of the analysis were overall survival (OS), progression free survival (PFS), local control (LC) and toxicity.
Results: 136 patients were treated from 2012 to 2020 on 451 oligometastases. Most common primary tumor was colorectal cancer (44.1%) followed by lung cancer (11.8%). A total of 3, 4 and 5 lesions were simultaneously treated in 102 (75.0%), 26 (19.1%), and 8 (5.9%) patients, respectively. Median total tumor volume (TTV) was 19.1 cc (range 0.6 - 245.1). With a median follow-up of 25.0 months, OS at 1 and 3 years was 88.4% and 50.2%, respectively. Increasing TTV was independent predictive factor of worse OS (HR 2.37, 95%CI 1.18 – 4.78, p=0.014) and PFS (HR 1.63, 95%CI 1.05 – 2.54; p=0.028). Median OS was 80.6 months if tumor volume was ≤ 10 cc (1 and 3 years OS rate 93.6% and 77.5%, respectively), and 31.1 months if TTV was higher than 10 cc (1 and 3 years OS rate 86.7% and 42.3%, respectively). Rates of LC at 1 and 3 years were 89.3% and 76.5%. In terms of toxicity, no grade 3 or higher toxicity was reported both in the acute and late settings.
Conclusion: We demonstrated the impact of tumor volume on survival and disease control of patients affected by multiple oligometastases treated with single course SABR.
Effects of C-reactive protein trajectories of critically ill patients with sepsis on in-hospital mortality rate
Authors: Jiang Xuandong , Zhang Chenlu , Pan Yuting , Cheng Xuping , Zhang Weimin 
Published: April 2023

Abstract
Sepsis, a life-threatening condition caused by an inflammatory response to systemic infection, results in a significant social burden and healthcare costs. This study aimed to investigate the relationship between the C-reactive protein (CRP) trajectories of patients with sepsis in the intensive care unit (ICU) and the in-hospital mortality rate. We reviewed 1,464 patients with sepsis treated in the ICU of Dongyang People's Hospital from 2010 to 2020 and used latent growth mixture modeling to divide the patients into four classes according to CRP trajectory (intermediate, gradually increasing, persistently high, and persistently low CRP levels). We found that patients with intermediate and persistently high CRP levels had the lowest (18.1%) and highest (32.6%) in-hospital mortality rates, respectively. Multiple logistic regression analysis showed that patients with persistently high (odds ratio [OR] = 2.19, 95% confidence interval [CI] = 1.55–3.11) and persistently low (OR = 1.41, 95% CI = 1.03–1.94) CRP levels had a higher risk of in-hospital mortality than patients with intermediate CRP levels. In conclusion, in-hospital mortality rates among patients with sepsis differ according to the CRP trajectory, with patients with intermediate CRP levels having the lowest mortality rate. Further research on the underlying mechanisms is warranted.
Crosslinked oxidized-nanocellulose/chitosan hydrogels as a scaffold matrix for mesenchymal stem cell growth
Authors: Mariño Mayra A. , Oyarce Karina , Tovar Catalina , Segura Rodrigo , Paredes Gabriela , Pavez Paulina , Sarabia Mauricio , Amoroso Alejandro , Concha Jose L. , Norambuena-Contreras Jose , Barajas Gustavo Cabrera , Castaño Johanna 
Published: April 2023

Abstract
Mesenchymal stem cells (MSC) are recognized for their immunomodulatory effects and regenerative properties, being promising therapeutic agents for a wide range of diseases. To ensure a localized effect of MSC in the organism, biobased hydrogels have been tested for their ability to acting as a matrix-embedded to improves MSC targeted delivery. In this context, nanocellulose (NC) has been used for drug delivery, showing biocompatibility and, durability in time, but until now NC not been tested for MSC growth exploiting the size and aldehyde content of NC. In this study, cellulose nanocrystals (CNC), cellulose nanofibers (CNF) and microfibrillated cellulose (MFC) were studied after one-pot oxidation and further crosslinking with chitosan (mass ratio 1:5). Size and aldehyde content of oxidized NC samples were evaluated to analyze their influence on the hydrogel’s properties. The crosslinked hydrogels were analyzed by FESEM, swelling ability, FTIR, compression tests, thermal stability, and stability in culture cell conditions. Oxidized-MFC hydrogel improved the mechanical stability and swelling behavior, but it lacks stability at cell conditions possibly due to its low aldehyde content (0.54 mmol/g). Conversely, oxidized CNF and oxidized CNC formed suitable crosslinked hydrogels for cell adhesion, and for growing and proliferating of MSC 3D spheroids after 120 h. However, only hydrogel with PO-CNF/chitosan shows antibacterial activity as well as MSC proliferation.
Development, validation, and psychometric analysis of Foot and Ankle Flexibility Index (FAFI)
Authors: Martinez-Sebastian Carlos , Gijon-Nogueron Gabriel , AM Angela Margaret Evans , Asencio Jose Miguel Morales , Molina-Garcia Cristina , Ramos-Petersen Laura 
Published: April 2023

Abstract

Objective
To develop a new diagnostic tool for joint hypermobility of the paediatric foot and ankle, based on a dichotomous scoring system, the validated Lower Limb Assessment Score (LLAS). With separation of the foot and ankle items, we obtained a new diagnostic tool for joint hypermobility of the foot and ankle, specifically, based on a dichotomous scoring system.
Methods
A total of 205 children between 5 and 10 years of age participated in the present cross-sectional study. The new tool Foot and Ankle Flexibility Index (FAFI) was the choice of the last 7 items of LLAS, which are specific to assess the foot and ankle. The internal consistency was measured with Cronbach’s test. Kappa statistics with 95% CI were calculated to verify the level of inter-rater and intra-rater agreement for the FAFI test.
Results
Cronbach's alpha returned 0.82. The correlations between items returned a mean of 0.59 (range: 0.43–0.74). The discrimination score on the ROC curve (4 points) showed that the model can be used to identify children with joint hypermobility of the foot and ankle.
Conclusions
This study identified high reliability between evaluators, and high sensitivity and specificity, for a new reliable and valid tool for the diagnosis of foot and ankle joint hypermobility.
IoT and Radio Telemetry based Wireless Engine Control and Real-Time Position Tracking System for an Agricultural Tractor
Authors: SHRIVASTAVA PRATEEK , Tewari V. K. , Gupta Chanchal , Singh Gajendra 
Published: April 2023

Abstract
Internet of Things (IoT) has presented a new scope in the field of Precision Agriculture. With the application of cloud computing and WiFi-based long-distance network in IoT, it is possible to connect the farmers of rural areas effectively and harness the benefit of its advancement. In the present research work, an IoT-based scalable network architecture has been designed for two capabilities 1. For starting and stopping the tractor engine from a remote location and 2. For real-time tracking of the position and monitoring the engine status on a developed website. The developed system consists of the on-board unit (OBU), web server, and google map-based webpage. The OBU consists of the Engine Control Unit (ECU) along with a GPS tracking device for presenting the real-time information on a website. The ECU consists of an RF-based wireless transmitting and receiving system to start and stop the remotely situated tractor engine. As the tractor engine starts it automatically powers up the GPS device for acquiring real-time information i.e. Longitude, Latitude, Time, speed, and Date from satellites, and sends it to the OBU. The Raspberry Pi-3 which has been used as the central processing unit in OBU, gathers both position and engine information and processes it after that sends it to the webserver, where these data are stored in the database of the web server and can be retrieved as a request for position browsing on the map. Finally, a web application has been created using Python, language and also embedded with Google Map to retrieve and display real-time information. The developed system enables tractor owners to monitor the real-time position and status of the engine of their targeted tractor on Google Map through a pre-designed website. The developed system has been found to be very simple and can be used by skilled farmers as well.
Staff perceptions of factors affecting the use of RAS-DS to support collaborative mental health practice
Authors: Honey Anne , Hancock Nicola , Scanlan Justin Newton 
Published: April 2023

Abstract
Background The Recovery Assessment Scale: Domains and Stages (RAS-DS) is designed as both a recovery outcome measure and a tool to enhance service-user control over their recovery journey. While extensively and globally used in mental health services for the former purpose, routine use for the latter purpose is yet to be realised. The aim of this study was to identify barriers, facilitators and additional supports needed for use of RAS-DS to support service user participation, goal setting and recovery action planning.Methods An online survey was conducted of mental health workers who had engaged with RAS-DS, including fixed choice and open-ended questions. Data were analysed using descriptive statistics and interpretive content analysis respectively.Results The 65 respondents reported more frequent use of RAS-DS as an outcome measure than as a collaboration tool and more than half reported difficulties in using it in this way. Factors that they described as influencing the use of RAS-DS as a tool for collaboration and support were previous experiences with RAS-DS, organisational supports and policies, awareness of the RAS-DS amongst colleagues; RAS-DS related training and support; staff time and capacity; the format of the RAS-DS; the service user population or context; and respondents’ own active efforts.Conclusions Extending the use of RAS-DS, an already widely used tool, to routinely support recovery-oriented practice has benefits of efficiency and service user empowerment. However further work is needed to enable this, including: provision of co-designed, accessible training resources; a user platform including built in guidance; and strategies to promote management understanding and valuing of the opportunities inherent in RAS-DS for enhanced service delivery.
A Multi-angle Bidirectional Interaction Model for Entity Linking
Authors: Ji Lin , Hui Bei , Nian Yuhui , Zhou Wei , Qiu Jiajun 
Published: April 2023

Abstract
The process of connecting references in a text to appropriate entities in a knowledge graph is known as entity linking. The existing entity linking model learns local compatibility through content and global interdependencies through relevant knowledge graph for disambiguation. However, the local compatibility component of existing methods usually ignores the multi-angle interactions between mentions and candidate entities. In order to fully account for the bidirectional connection between the input document and the knowledge graph, we propose the Bidirectional Interaction Entity Linking (BI-INTEL). The correlation between mentions and candidate entities, as well as the applicability of mention context and candidate entity descriptions, are all taken into account in the local compatibility component. In the global interdependence component, our stacked random walk layers learn the global interdependence of the candidate entity to enhance the accuracy of entity linking. According to the experiments, our BI-INTEL performs 3% better on average than cutting-edge methods.
Optimizing treatment of brain metastases in an era of novel systemic treatments: a single center consecutive series
Authors: Schie P. , Rijksen B. L.T. , Bot M. , Wiersma T. , Merckel L. G. , Brandsma D. , Compter A. , Hamer P. C. Witt , Post René , Borst Gerben 
Published: April 2023

Abstract
Background
The multidisciplinary management of patients with brain metastases consists of surgical resection, radiation treatment and systemic treatment. Tailoring and timing these treatment modalities is challenging. This study presents real-world data from consecutively treated patients and assesses the impact of all treatment strategies and their relation with survival. The aim is to provide new insights to improve multidisciplinary decisions towards individualized treatment strategies in patients with brain metastases.
Methods
A retrospective consecutive cohort study was performed. Patients with brain metastases were included between June 2018 and May 2020. Brain metastases of small cell lung carcinoma were excluded. Overall survival was analyzed in multivariable models.
Results
676 patients were included in the study, 596 (88%) received radiotherapy, 41 (6%) awaited the effect of newly started or switched systemic treatment and 39 (6%) received best supportive care. Overall survival in the stereotactic radiotherapy group was 14 months (IQR 5-32) and 32 months (IQR 11-43) in patients who started or switched systemic treatment and initially did not receive radiotherapy. In patients with brain metastases without options for local or systemic treatment best supportive care was provided, these patients had an overall survival of 0 months (IQR 0-1). Options for systemic treatment, Karnofsky Performance Score ≥70 and breast cancer were prognostic for a longer overall survival, while progressive extracranial metastases and whole-brain-radiotherapy were prognostic for shorter overall survival.
Conclusions
Assessing prognosis in light of systemic treatment options is crucial after the diagnosis of brain metastasis for the consideration of radiotherapy versus best supportive care.
Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments
Authors: Liu Xiao-Fan , Zhao Shu-Wan , Cui Jin-Jin , Gu Yue-Wen , Fan Jing-Wen , Fu Yu-Fei , Zhang Ya-Hong , Yin Hong , Chen Kun , Cui Long-Biao 
Published: April 2023

Abstract
Background:
Cognitive impairment is the main factor in poor prognosis of schizophrenia, but its mechanism remains unclear. The inferior parietal lobule (IPL) is related to various clinical symptoms and cognitive impairment in schizophrenia. We aimed to explore the relationship between IPL-related functions and cognitive impairment in schizophrenia.
Methods:
136 schizophrenia patients and 146 demographically matched healthy controls were enrolled. High-spatial-resolution structural images and resting-state functional images were acquired to demonstrate the alternations of brain structure and function, while the digit span and digit symbol task of the Chinese Wechsler Adult Intelligence Test Revised (WAIS-RC) were utilized in assessing the cognitive function of the subjects. Based on the Allen Human Brain Atlas, we obtained genes that were differentially expressed in the left IPL and then intersected with the results of transcriptome-wide association study results.
Results:
We found a negative correlation between digit span backward task score and amplitude of low-frequency fluctuation (ALFF) of the left IPL in healthy controls (r= −0.388, P = 0.003), which was not seen in patients (r = 0.203, P = 0.020). In addition, none of the other correlation analyses wasstatistically significant (P > 0.017). In addition, We found that diacylglycerol kinase ζ (DGKζ) is differentially expressed in the left IPL and associated with schizophrenia.
Conclusion:
Our study demonstrates the left IPL plays a vital role in cognitive impairment in schizophrenia. DGKζ may act as an essential regulator in the left IPL of schizophrenia patients with cognitive impairment.
Mechatronic Design of A Composite Vibration Isolation System
Authors: Ghoneam Sobhy , Hamada Ahmed , Elkholy Ahmed M. 
Published: April 2023

Abstract

Composite materials have attracted researchers in vibration and noise control applications due to their significant dynamic characteristics such as high strength and high damping level. In this paper, a Glass Fiber Reinforced Composite material (GFRC) is presented as a vibration isolation system to control vibration levels in industry. A prototype of an industrial cam–follower machine is motorized, and the Frequency Response Function (FRF) is recorded using a B&K data acquisition analyzer at five rotational speeds. The transmitted vibrations to the machine foundation are estimated without any isolation system. Then, two optimized GFRC plates of optimum stacking sequences are used as an isolation system to reduce the transmitted vibration. The displacement transmissibility is calculated theoretically and experimentally. Furthermore, the isolation system is integrated with a mechatronic system for improving the isolation performance and enhancing the machining process. The results show that the use of GFRC plates as an isolator reduces the vibration level of the system by 98.46% and 98.5% for [90/90/90/0/0]s and [90/±45/±35/90/±35]s GFRC configurations respectively. Finally, this study proposes a novel strategy for isolation and vibration control technique by employing GFRC plates. The proposed mechatronics control system can be utilized for enhancing system performance and increasing the control of vibration levels.
Teenage pregnancy- An unsolved problem of the 21st century. Populational register-based study in Clinical County Hospital Constanta
Authors: Brezeanu Dragos , Brezeanu Ana Maria , Tomescu Cezar- Laurentiu , Serbanescu Lucian , Tica Vlad-Iustin 
Published: April 2023

Abstract
Teenage pregnancy refers to pregnancy that occurs in adolescent females under the age of 18 years old, although some authors include females under the age of 20 years old. Teenage girls have a higher risk of developing complications related to pregnancy, and the rate of caesarean section can rise dramatically. Cases of teenage women with pregnancy must be approached in a multidisciplinary manner and need a closer check-out than other pregnancies.
The following study was conducted in the Clinical County Hospital, Saint Andrew the Apostle’ Constanta, over a period of five years, between 2018-2022, and followed the incidence, socio-cultural environment, rate of caesarean section and indications for surgery.
Venetoclax plus Azacitidine as the Induction Therapy for Cardiac Myeloid Sarcoma - A Case Report with Review of Literature
Authors: Lin Li-Chun , Wu Cho-Kai , Lu Cheng-Hsun , Shun Chia-Tung , Huang Tai-Chung 
Published: April 2023

AbstractBackgroundCardiac myeloid sarcoma is a rare extramedullary tumor of acute myeloid leukemia, and its optimal treatment strategy has not been established such as avoiding conventional anthracycline-containing induction chemotherapy because of unwanted cardiotoxicity. Recently, venetoclax combined with azacitidine was approved for newly diagnosed acute myeloid leukemia patients who are not unsuitable for intensive chemotherapy. To the best of our knowledge, there have been no reported cases of cardiac myeloid sarcoma treated with this combination regimen.Case presentationA 63-year-old man presented with progressive dyspnea on exertion. Echocardiography showed a massive pericardial effusion. Computed tomography of the chest revealed an infiltrative mass at the right atrioventricular groove with thickened epicardium and pericardium, and multifocal lymphadenopathy. Initially, he was suspected to have IgG4-related disease and Erdheim-Chester disease, based on elevated serum lgG4 levels and histopathological findings of axillary lymph node and endomyocardial biopsy. Despite treatment, his left ventricular systolic dysfunction rapidly deteriorated. Peripheral blood blasts were unexpectedly observed later, and subsequent bone marrow examination confirmed acute myeloid leukemia. Retrospective review of the endomyocardial biopsy specimen verified the diagnosis of cardiac myeloid sarcoma. To minimize the risk of chemotherapy-induced cardiotoxicity, we chose venetoclax plus azacitidine as induction therapy, followed by high-dose cytarabine consolidation and allogeneic hematopoietic stem cell transplant, which lead to a complete remission.ConclusionsAlthough extremely rare, cardiac myeloid sarcoma can cause fulminant heart failure and should be included in the differential diagnosis of cardiac tumors, even without a prior history of hematologic disorders. Our report demonstrates for the first time that the combination of venetoclax and azacitidine is an effective and safe induction therapy for cardiac myeloid sarcoma.
Synergic effect of Arbuscular mycorrhizal fungi and potassium fertilizer improves biomass-related characteristics of cocoa seedlings to enhance their drought resilience and field survival
Authors: Kwashie Godswill K.S , Kaba James S. , Abunyewa Akwasi A. , Appiah-Kubi Zippora , Asare Alberta Y. , Agyei Ernest K. 
Published: April 2023

Abstract

Drought stress has become the most widespread environmental factor that affects cocoa production in West Africa. This study assessed the effect of AMF and or potassium fertilizer on cocoa drought resilience and survival at the nursery stage to 2 years after transplanting to field. Nursery and field experiments were conducted at the FRNR Farm (6043 N and 1036 W), KNUST- Ghana from 2020 to 2022. A 3x3x2 factorial experiment with three cocoa varieties (V1, V2 and V3), three levels (0, 2 and 4g plant− 1) of potash and AMF spore treatment (AMF and Non-AMF) in a Randomized Complete Block Design was used. Soil samples (0-20cm depth) from cocoa rhizosphere in five farms were examined for native AMF spores and structures using the Wet Sieving and Decantation methodology and the Sucrose Centrifugation Technique. AMF inoculum was prepared using the trap culture technique. At the nursery, K levels with AMF recorded the highest stem diameter (8.3mm) than the non-AMF seedlings (7.9mm). 2g and 0g K with AMF in V2 and V3 had the highest (p < 0.05) plant heigh (50.27cm). 2g K x AMF in V1 and V2 had the highest aboveground (5.13g) and belowground (2.81g) biomass respectively. At 24 months, V1x0g and V3x4g both without AMF had mortality of 60% and 50% respectively, while V1x4g and V2x2g both with AMF had 2% mortality rate. This synergy improved the field survival of cocoa from the current 30–98%. This has implications for cocoa nutrients management and drought conditions that threaten sustainable cocoa production.
Quantum atmosphere effective radii for different spin fields from quantum gravity inspired black holes
Authors: Gingrich Douglas M. 
Published: April 2023

Abstract
Quantum atmosphere effective radii for the emission of spin-0, 1/2, 1, and 2 massless fields from Schwarzschild, Tangherlini, non-commutative geometry inspired, and polymeric black holes are calculated. The power observed from the black hole at spatial infinity taking greybody factors into account is compared to an equal-power black-body radiator of the same temperature but different effective radius. A large range of different radii are obtained for different spin fields and black holes. The equal-power black-body effective radius is not, in general, a good proxy for the location of the quantum atmosphere.