bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myenteric Plexus Immune Cell Infiltrations and Neurotransmitter Expression in Crohn’s Disease and Ulcerative Colitis
Authors: Wiese Jakob J , Manna Subhakankha , Kühl Anja A , Fascì Alberto , Elezkurtaj Sefer , Sonnenberg Elena , Bubeck Marvin , Atreya Raja , Becker Christoph , Weixler Benjamin , Siegmund Britta , Patankar Jay V , Prüß Magdalena S , Schumann Michael 
Published: August 2023

Abstract

Background and Aims
Pain is a cardinal symptom in inflammatory bowel disease [IBD]. An important structure in the transduction of pain signalling is the myenteric plexus [MP]. Nevertheless, IBD-associated infiltration of the MP by immune cells lacks in-depth characterisation. Herein, we decipher intra- and periganglionic immune cell infiltrations in Crohn´s disease [CD] and ulcerative colitis [UC] and provide a comparison with murine models of colitis.

Methods
Full wall specimens of surgical colon resections served to examine immune cell populations by either conventional immuno-histochemistry or immunofluorescence followed by either bright field or confocal microscopy. Results were compared with equivalent examinations in various murine models of intestinal inflammation.

Results
Whereas the MP morphology was not significantly altered in IBD, we identified intraganglionic IBD-specific B cell- and monocyte-dominant cell infiltrations in CD. In contrast, UC-MPs were infiltrated by CD8+ T cells and revealed a higher extent of ganglionic cell apoptosis. With regard to the murine models of intestinal inflammation, the chronic dextran sulphate sodium [DSS]-induced colitis model reflected CD [and to a lesser extent UC] best, as it also showed increased monocytic infiltration as well as a modest B cell and CD8+ T cell infiltration.

Conclusions
In CD, MPs were infiltrated by B cells and monocytes. In UC, mostly CD8+ cytotoxic T cells were found. The chronic DSS-induced colitis in the mouse model reflected best the MP-immune cell infiltrations representative for IBD.
Cardiac resynchronization therapy using conduction system pacing after double-switch surgery for congenitally corrected transposition of the great arteries: a case report
Authors: De Becker Benjamin , O’Neill Louisa , Pierard Sophie , Le Polain De Waroux Jean-Benoit 
Published: August 2023

Abstract

Background
Patients with congenitally corrected transposition of the great arteries (ccTGA) are at risk of developing conduction disease and complete atrio-ventricular block and this risk increases after corrective cardiac surgery. However, the optimum pacing modality remains controversial.

Case summary
Twelve years after a double-switch surgery with ventricular septal defect correction, a 16-year-old ccTGA female was referred with an indication for cardiac resynchronization therapy. In the absence of coronary sinus (CS) or direct access to the conduction system, several therapeutic options were considered. Finally, using a three-dimensional navigation system and customized sheaths, a left bundle branch area pacing (LBBAP) lead was successfully implanted. The implantation resulted in stable pacing parameters and positive haemodynamic changes. At 9-month follow-up, pacing parameters were stable and the patient reported a significant improvement in quality of life.

Discussion
Cardiac resynchronization therapy in adults with repaired congenital heart disease remains challenging, especially in the absence of CS or direct access to the conduction system. In such a situation, LBBAP appears as an attractive alternative pacing modality. However, pre-operative management is critical to the success of the implantation.
Expressway to Votes: Infrastructure Projects and Voter Persuasion
Authors: Akbulut-Yuksel Mevlude , Okoye Dozie , Turan Belgi 
Published: August 2023

Abstract
This paper provides causal evidence on how political parties can sway voters at scale in nascent electoral democracies. We collect novel data on expressway construction by the Justice and Development Party in Turkey and use province-by-year variation in construction to show that votes for the Justice and Development Party increased in response to the expressways. The estimates imply that the expressways increased the Justice and Development Party’s vote share by 4.8 percentage points—a third of the increase from 2002 to 2011. We provide evidence that the visibility and competence signalled by the expressway expansion, and not increased local economic growth, drove increased vote shares.
Leflutrozole in male obesity-associated hypogonadotropic hypogonadism: Ph 2b double-blind randomised controlled trial
Authors: Jones T Hugh , Dobs Adrian S , Randeva Harpal , Moore William , Parkin Jacqueline M 
Published: August 2023

Abstract

Objective
Assessment of the efficacy and safety/tolerability of the aromatase inhibitor leflutrozole to normalise testosterone in Obesity-associated Hypogonadotropic Hypogonadism (OHH).

Design
Placebo-controlled, double-blind, RCT, in 70 sites in Europe/USA.

Methods
Patient inclusion criteria: men with BMI of 30-50 kg/m2, morning total testosterone (TT) &lt; 10.41 nmol/L, and two androgen deficiency symptoms (at least one of sexual dysfunction). Patients randomised to weekly leflutrozole (0.1/0.3/1.0 mg) or placebo for 24 weeks. Primary endpoint: normalisation of TT levels in ≥75% of patients after 24 weeks. Secondary endpoints (included): time to TT normalisation and change in LH/FSH. Safety was assessed through adverse events and laboratory monitoring.

Results and Conclusions
Of 2103 screened, 271 were randomised, 81 discontinued. Demographic characteristics were similar across groups. Mean BMI was 38.1 kg/m2 and TT 7.97 nmol/L. The primary endpoint was achieved in all leflutrozole-treated groups by 24 weeks with a dose-tiered response; mean TT 15.89; 17.78; 20.35 nmol/L, for leflutrozole 0.1 mg, 0.3 mg, and 1.0 mg groups respectively, vs 8.04 nmol/L for placebo. LH/FSH significantly increased in leflutrozole vs placebo groups. No improvements in body composition or sexual dysfunction were observed. Semen volume/total motile sperm count improved with leflutrozole vs placebo. Treatment-emergent adverse events, more common in leflutrozole-treated groups included, raised haematocrit, hypertension, increased PSA, and headache. Some reduction in lumbar bone density was observed with leflutrozole (mean −1.24%, −1.30%, −2.09%) and 0.66% for 0.1 mg, 0.3 mg, 1.0 mg, and placebo, respectively, without change at the hip. This RCT of leflutrozole in OHH demonstrated normalisation of TT in obese men. FSH/LH and semen parameter changes support that leflutrozole may preserve/improve testicular function.

Clinical Trial Registration number
NCT02730169.
Do physician networks with standardized audit and feedback deliver better quality care for older patients compared to regular care?: a quasi-experimental study using claims data from Bavaria, Germany
Authors: Iashchenko Iryna , Flemming Ronja , Franke Sebastian , Sundmacher Leonie 
Published: August 2023

AbstractBackgroundPhysician networks (PNs) are a recent development in Germany, designed to improve the coordination and quality of healthcare. We compared the performance of PNs that use a standardized system of audit and feedback to that of regular care.MethodsWe analysed a large sample of claims data from Bavaria, Germany, using nearest-neighbour propensity score matching. Patients who had ambulatory care-sensitive conditions (ACSCs) and were enrolled in PNs were matched with control patients receiving regular care. We examined potentially avoidable hospitalizations related to the 13 most common ACSCs (primary endpoints), as well as processes-of-care indicators for disease prevention, pharmacotherapy and coordination of care.ResultsThere were no significant differences in rates of potentially avoidable hospitalizations between the two groups. However, the networks showed higher vaccination rates, increased participation in disease management programmes, and more frequent use of referrals when consulting specialist physicians. On average, network patients visited a greater number of specialists and had lower continuity of care compared to patients receiving regular care. Polypharmacy and PRISCUS-list prescriptions were more prevalent in the networks.ConclusionsPNs using audit and feedback do not appear to perform better than regular care in preventing hospitalizations due to ACSCs. However, they do perform better in disease prevention measures while showing inconclusive results for care coordination and pharmacotherapy. Further research is needed to understand effective collaboration among providers and its impact on the quality of care within PNs.
Biogeographic patterns in populations of marine Pseudoalteromonas atlantica isolates
Authors: Kokate Prajakta P , Bales Erika , Joyner Dominique , Hazen Terry C , Techtmann Stephen M 
Published: August 2023

Abstract
Intra-specific genomic diversity is well documented in microbes. The question, however, remains whether natural selection or neutral evolution is the major contributor to this diversity. We undertook this study to estimate genomic diversity in Pseudoalteromonas atlantica populations and whether the diversity, if present, could be attributed to environmental factors or distance effects. We isolated and sequenced twenty-three strains of P. atlantica from three geographically distant deep marine basins and performed comparative genomic analyses to study the genomic diversity of populations among these basins. Average nucleotide identity followed a strictly geographical pattern. In two out of three locations, the strains within the location exhibited &gt;99.5% identity, whereas, among locations, the strains showed &lt;98.11% identity. Phylogenetic and pan-genome analysis also reflected the biogeographical separation of the strains. Strains from the same location shared many accessory genes and clustered closely on the phylogenetic tree. Phenotypic diversity between populations was studied in ten out of twenty-three strains testing carbon and nitrogen source utilization and osmotolerance. A genetic basis for phenotypic diversity could be established in most cases but was apparently not influenced by local environmental conditions. Our study suggests that neutral evolution may have a substantial role in the biodiversity of P. atlantica.
High-precision polar motion prediction using EOP_20_C04 and EAM based on CSLS+AR and CSLS+LSTM methods
Authors: Kong Qiaoli , Han Jingwei , Wu Yuanwei , Wang Tianfa , Chen Yanfei 
Published: August 2023

SUMMARYHigh-precision prediction of polar motion (PM) plays an important role in fields such as astronomy, geodesy, navigation and aerospace. Incorporating information on the effective angular momentum (EAM) of the geophysical fluid is an effective way to improve the precision of PM prediction. Based on the EOP_20_C04 data set and the EAM function, this study applies complex segmented least-squares (CSLS) + the long short term memory (LSTM) neural network and CSLS + autoregression (AR) models to predict PM. For the 6-d PM prediction, the mean absolute errors (MAEs) achieved by CSLS+AR are 1.03 and 0.8 mas in the X- and Y-directions, respectively, corresponding to reductions of 45.80 and 31.97 per cent when compared to predictions reported routinely in Bulletin A of the International Earth Rotation and Reference Systems Service (IERS). For the 365-d PM prediction, the MAEs gained by CSLS+LSTM model are 14.58 and 10.59 mas in the X- and Y-directions, respectively, corresponding to reductions of 28.17 and 51.09 per cent compared to predictions of the Bulletin A, and the prediction accuracy attained by CSLS+LSTM is higher than other prediction schemes. The experimental results show that, when considering EAM information, the CSLS+AR model can achieve better prediction accuracy for short-term PM prediction, however, the CSLS+LSTM model is more effective for medium- and long-term PM prediction owning to the excellent nonlinear fitting capability of the LSTM deep learning algorithm.
Chromosome-scale genome sequence of Suaeda glauca sheds light on salt stress tolerance in halophytes
Authors: Cheng Yan , Sun Jin , Jiang Mengwei , Luo Ziqiang , Wang Yu , Liu Yanhui , Li Weiming , Hu Bing , Dong Chunxing , Ye Kangzhuo , Li Zixian , Deng Fang , Wang Lulu , Cao Ling , Cao Shijiang , Pan Chenglang , Zheng Ping , Wang Sheng , Aslam Mohammad , Wang Hong , Qin Yuan 
Published: August 2023

Abstract
Soil salinity is a growing concern for global crop production and the sustainable development of humanity. Therefore, it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance crop tolerance to salt stress. Suaeda glauca, a halophyte species well adapted to the seawater environment, possesses a unique ability to absorb and retain high salt concentrations within its cells, particularly in its leaves, suggesting the presence of a distinct mechanism for salt tolerance. In this study, we performed de novo sequencing of the S. glauca genome. The genome has a size of 1.02 Gb (consisting of two sets of haplotypes) and contains 54 761 annotated genes, including alleles and repeats. Comparative genomic analysis revealed a strong synteny between the genomes of S. glauca and Beta vulgaris. Of the S. glauca genome, 70.56% comprises repeat sequences, with retroelements being the most abundant. Leveraging the allele-aware assembly of the S. glauca genome, we investigated genome-wide allele-specific expression in the analyzed samples. The results indicated that the diversity in promoter sequences might contribute to consistent allele-specific expression. Moreover, a systematic analysis of the ABCE gene families shed light on the formation of S. glauca’s flower morphology, suggesting that dysfunction of A-class genes is responsible for the absence of petals in S. glauca. Gene family expansion analysis demonstrated significant enrichment of Gene Ontology (GO) terms associated with DNA repair, chromosome stability, DNA demethylation, cation binding, and red/far-red light signaling pathways in the co-expanded gene families of S. glauca and S. aralocaspica, in comparison with glycophytic species within the chenopodium family. Time-course transcriptome analysis under salt treatments revealed detailed responses of S. glauca to salt tolerance, and the enrichment of the transition-upregulated genes in the leaves associated with DNA repair and chromosome stability, lipid biosynthetic process, and isoprenoid metabolic process. Additionally, genome-wide analysis of transcription factors indicated a significant expansion of FAR1 gene family. However, further investigation is needed to determine the exact role of the FAR1 gene family in salt tolerance in S. glauca.
Fisheries measures protect European seabass groups with distinct habitat use differently
Authors: Goossens Jolien , Villagra Damian , De Putter Georges , Verhelst Pieterjan , Torreele Els , Moens Tom , Reubens Jan 
Published: August 2023

Abstract
We investigated the movements of European seabass, Dicentrarchus labrax, to understand habitat use and connectivity to evaluate how individual seabass are protected by the spatiotemporal fisheries restrictions in place. We tagged seabass with acoustic transmitters in a study area in the Port of Zeebrugge (Belgium) in the southern North Sea. The 370,200 detections of 57 seabass in the study area revealed high residency in the period from late March–May to September–November, as well as high site fidelity (70.7%). Whereas the majority of seabass left the area in winter, 13 seabass stayed in the harbour experiencing temperatures as low as 2.8°C. Two groups of seabass were identified having different core movement areas in the inner and outer harbours, although movement between the two areas was possible. The distinct differences in habitat use between these groups resulted in a significantly different level of exposure to fisheries under the same policy framework. By quantifying the level of protection of seabass, based on the spatiotemporal fisheries management in place, our study underlines the importance of taking into account movement behaviour when evaluating conservation measures.
Recycling unused medications in hospitals is financially viable and good for the environment
Authors: Drummond Isla , Bains Rajan , Dosanjh Anmol , Ladhar Simroop , Tang Linda , Heidary Deborah , Tejani Aaron M 
Published: August 2023

Abstract

Objectives
Considerable pharmaceutical waste is generated in hospital settings which can be reduced by recycling of unused medications. We sought to determine the recycling practices as well as quantify the volume and the value of oral solid medications returned from nursing units to the pharmacy departments at three urban hospitals.

Methods
Unused oral solid medications were recycled at three sites and the net financial impact of this practice was calculated (cost recovered – labour costs). The results were extrapolated to all 21 hospitals within the health system.

Key findings
Recycling medications in 21 hospitals could divert ~461 000 units of medication from the incinerator, with an estimated net value of ~$415 000 per year.

Conclusions
Recycling unused medications could save substantial amounts of money and reduce negative environmental impacts from disposal/incineration.
The Turán Density of Tight Cycles in Three-Uniform Hypergraphs
Authors: Kamčev Nina , Letzter Shoham , Pokrovskiy Alexey 
Published: August 2023

Abstract
The Turán density of an $r$-uniform hypergraph ${\mathcal {H}}$, denoted $\pi ({\mathcal {H}})$, is the limit of the maximum density of an $n$-vertex $r$-uniform hypergraph not containing a copy of ${\mathcal {H}}$, as $n \to \infty $. Denote by ${\mathcal {C}}_{\ell }$ the $3$-uniform tight cycle on $\ell $ vertices. Mubayi and Rödl gave an “iterated blow-up” construction showing that the Turán density of ${\mathcal {C}}_{5}$ is at least $2\sqrt {3} - 3 \approx 0.464$, and this bound is conjectured to be tight. Their construction also does not contain ${\mathcal {C}}_{\ell }$ for larger $\ell $ not divisible by $3$, which suggests that it might be the extremal construction for these hypergraphs as well. Here, we determine the Turán density of ${\mathcal {C}}_{\ell }$ for all large $\ell $ not divisible by $3$, showing that indeed $\pi ({\mathcal {C}}_{\ell }) = 2\sqrt {3} - 3$. To our knowledge, this is the first example of a Turán density being determined where the extremal construction is an iterated blow-up construction. A key component in our proof, which may be of independent interest, is a $3$-uniform analogue of the statement “a graph is bipartite if and only if it does not contain an odd cycle”.
Group von Neumann Algebras, Inner Amenability, and Unit Groups of Continuous Rings
Authors: Schneider Friedrich Martin 
Published: August 2023

Abstract
We prove that, if a discrete group $G$ is not inner amenable, then the unit group of the ring of operators affiliated with the group von Neumann algebra of $G$ is non-amenable with respect to the topology generated by its rank metric. This provides examples of non-discrete irreducible, continuous rings (in von Neumann’s sense) whose unit groups are non-amenable with regard to the rank topology. Our argument establishes and uses connections with Eymard–Greenleaf amenability of the action of the unitary group of a $\textrm{II}_{1}$ factor on the associated space of projections of a fixed trace.
Prevalence of Intimate Partner Violence and Associated Factors Among People With HIV: A Large-Sample Cross-Sectional Study in China
Authors: Wu Yu , Wang Yaping , Long Hai , Liu Lirong , Dai Lili , Cao Wanxian , Liu Jue , Liu Min 
Published: August 2023

Abstract
To assess the prevalence and exacerbating factors of intimate partner violence in people with human immunodeficiency virus (PWH) in China, we conducted a cross-sectional study, involving 2792 PWH in 4 provinces in China from 1 September 2020 to 1 June 2021. The categories of intimate partner violence (IPV) included physical violence, sexual violence, emotional abuse, and controlling behavior. The severity of a violent act was divided into mild, moderate, and severe. Among PWH, the prevalence of IPV was 15.4% (95% confidence interval, 14.1%–16.8%). The severity of physical violence was mainly moderate, and the severity of sexual violence, emotional abuse, and controlling behavior was mainly mild. The prevalence of IPV in men was higher than that in women. Results from the multivariable logistic regression showed that age, ethnic, registered residence, education, and duration of HIV antiretroviral therapy were factors related to IPV in PWH (P &lt; .05).
Integrative systematics and conservation of endangered Carabus nankotaizanus (Coleoptera: Carabidae) in Taiwan
Authors: Yeh Lan-Wei , Ko Hsin-Ping , Yang Ping-Shih , Wong Kwok-Ching , Sota Teiji , Lin Chung-Ping 
Published: August 2023

Abstract
The endangered endemic ground beetle, Carabus nankotaizanus Kano, 1932 (Coleoptera: Carabidae), consists of 4 subspecies distributed across the lowlands to mountain forests of Taiwan. However, continuous morphological variation among the subspecies and large altitudinal range gaps between lowland and mountain populations of C. nankotaizanus raise questions concerning its species boundaries. We assessed the species boundaries between lowland and mountain populations of C. nankotaizanus using an integrative approach combining morphological, molecular, life-history, and ecological traits. Future suitable habitats were predicted using ecological niche models to evaluate the effect of range shifts driven by climate warming. The analyses of morphological and ecological traits indicate that the lowland and mountain populations of C. nankotaizanus are 2 distinct phenetic and ecological species. The molecular phylogeny further supported 4 divergent groups (paraphyletic C. nankotaizanus sp. 1 of the northern lowland + monophyletic C. nankotaizanus sp. 2 of the northern mountain, paraphyletic C. nankotaizanus sp. 3 of the southeastern lowland + monophyletic C. nankotaizanus sp. 4 of the mountain groups). We recommend the designation of the 4 cryptic C. nankotaizanus as candidate species and officially protected evolutionary lineages. Future range shifts of C. nankotaizanus sp. 1 to higher latitudinal lowlands of northern Taiwan may pose significant challenges to its conservation due to urban development and island boundary. By contrast, upcoming range shifts of the mountain C. nankotaizanus species to higher altitudes of protected national parks and forest reserves in the Central Mountain Range may not represent a major threat to its survival.