bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncommon Medical Diagnostic Profiles in Psychiatric Settings Across South-south Nigeria
Authors: Uche Nwaopara 
Published: January 2023

Abstract

Medical disorders and emergencies may cause diagnostic puzzles, sometimes leading to negative patient outcomes, among mentally ill patients. The aim was to determine the uncommon medical diagnosis and their profiles among psychiatric settings in South-South, Nigeria: The study was done in centers across three states in a cross-sectional descriptive study that examined diagnostic profiles of a sample of 134 psychiatric patients that received medical care over one year (July 2021-July 2022) using questionnaires generated by the clinical team and ICD-10 medical diagnoses obtained from specialist reviews performed by consultant physicians from the medical team. Data analysis: was done using SPSS version 27. Chi-squared tests were conducted and a probability value of p < 0.05 was considered significant. The results showed that there was a preponderance of females with a frequency of 66.4% as compared to 33.6% for males. The most predominant age range was 10–19 years with 57 (42.5%) patients and 78.6% below 30 years. Most of the patients (49.25%) were married, 41.79% were single and 8.95% of participants were either separated or divorced. There was a statistically significant relationship between marital status, age, education, and medical diagnosis (X2 = 5.0, p = 0.02, X2=11.2, p = 0.00, X2 = 5.33, p = 0.02, respectively). Neurological medical conditions were the most predominant medical conditions found in the psychiatric settings used for the assessment with a value of 61.17%. while surgical co-morbidities were the least presenting diagnosis in psychiatric settings, with a value of 2.98%. Clinicians including the consultation-liaison psychiatrist, are therefore advised to have a high index of suspicion, about vulnerabilities within the diagnostic process of varied diseases, encountered in general medical or neuropsychiatric settings, to reduce diagnostic errors, mitigate morbidity and ultimately improve the outcome of the organic conditions.
Impact of COVID-19 on medical school admissions at The University of Arizona College of Medicine – Tucson
Authors: Mamaril-Davis James C. , Nguyen Mary , Yasmeh Jonathan P. , Leyva Emily , Li Ran , Wang Hongyi , Parikh Tejal 
Published: January 2023

Abstract
Background: The COVID-19 pandemic presented unforeseen obstacles to prospective medical students such as Medical College of Admission Test (MCAT) scheduling postponements and technical challenges during virtual interviews. Students were also faced with difficult decisions post-submission such as having to choose a program without ever visiting a school in-person.
Objective: The primary objective of the present study was to assess the effect of the COVID-19 pandemic on medical school admission preferences and application-related costs. This may also provide feedback to medical school administrators for future improvements to the application process.
Methods: A retrospective survey of the class of 2024 (Co24; non-COVID-19 cohort) and class of 2025 (Co25; COVID-19 cohort) was conducted in the Fall of 2021 via the Qualtrics online survey software. Statistical analysis incorporated the chi-square test on the Likert scale.
Results: There were 195 survey respondents: 77 students from the Co2024 and 89 students from the Co25. More students in the Co25 had to reschedule their MCAT compared to the Co24 (56.1% versus 14.3%; p <0.001). The in-person Co24 had higher travel-related expenses (>$500) compared to the Co25 who interviewed virtually (65.1% versus 2.4%; p <0.001). More students from the Co24 preferred the in-person interview format compared to the Co25 (85.7% versus 22.5%; p <0.001). Lastly, 87% of the Co24 and 24.7% of the Co25 felt they were able to gather a clear impression of the atmosphere and culture of a school from the interview trail alone (p <0.001).
Conclusion: Matriculated medical students at an allopathic medical school who applied during the COVID-19 pandemic had more pre-application hurdles when compared to prior cohorts. Students in the COVID-19 cohort, who primarily had virtual interviews, had less travel-related costs but felt more limited in their experience of a school’s culture. Despite this, however, the COVID-19 cohort still expressed a preference for virtual interviews.
A multi-objective particle swarm optimization based on maintaining dynamic population size
Authors: Yang Meilan , Liu Yanmin , Shu Xiaoli , Zhang Qian , Chen Fei 
Published: January 2023

Abstract

In recent decades, to efficiently solve multi-objective optimization problems, researchers have further studied and proposed many improved multi-objective particle swarm optimization algorithms, most of which adopt fixed population size. In the search process, if the population size is not set properly, it will affect the search effect of the algorithm and the calculation time will be too long. Meanwhile, these algorithms still have some challenges in balancing diversity and convergence. To deal with the above problems, a multi-objective particle swarm optimization based on maintaining dynamic population size (MOPSO-MDP) is proposed. Firstly, an improved update strategy of personal best solution and global best solution is introduced into the algorithm, which is helpful to improve its search ability and its ability to jump out of the local optimum. Then, the algorithm introduces a strategy of maintaining population growth, which can improve the quality of individuals and the diversity of the population. At the same time, a maintaining population reduction strategy is also proposed, which helps to maintain the quality of individuals in the population and avoid too long calculation time of the algorithm. Finally, the numerical experiments compare the proposed MOPSO-MDP with ten typical evolutionary algorithms on selected 22 test problems. The numerical experimental results show that the proposed MOPSO-MDP has noticeable advantages in population diversity and convergence ability on these 22 test problems.
Influence of Multiplicity on Properties of Ndx (X= 6, 7 and 8) Halide Transition Metal(Ii) Complexes of Glyoxime Ligand in Gas Phase and Aqueous Solution: Computational Assessment
Authors: LEONIE DJENDO MAZIA SUZANE , JEAN MOTO ONGAGNA , IDRICE ADJIEUFACK ABEL , Daniel LISSOUCK , CLAUDE NDOM JEAN , DÉSIRÉ BIKELE MAMA 
Published: January 2023

Abstract
The present paper has been focused on the ability of the glyoxime ligand to chelate to the [MX2] inorganic moieties in which M and X refer respectively to ndx transition metal(x = 6,7 and 8) and halogenated ligand(X =Br or Cl). The geometry optimizations at B3LYP/GEN level(LanL2DZ and 6-311+G (d,p) respectively for ndx transition metals (as well as halogen atoms) and for others atoms) have integrated the alteration of the multiplicity in each study media (gas phase and water). The passage from the fourth period transition metals to the sixth period ones enhances the reactivity of the complexes obtained regardless in gas phase. The metal-nitrogen bonds within higher multiplicity ndx (x=7,8) transition metal complexes are most unstable in both media. The [glyoxime ligand] ….[MX2] interaction strength increases in the following order: Fe2+< Co2+< Ni2+(3d series); Pd2+< Rh2+< Ru2+ (4d series) and Pt2+< Ir2+< Os2+ (5d series). For lower multiplicity bromide complexes exclusively, the enhancement of the donor character of the organic glyoxime ligand is promoted by its solvation except for nd6 transition metal complexes.
Imaging of brain electric field networks
Authors: Frank Lawrence , Galinsky Vitaly , Townsend Jeanne , Mueller Ralph-Axel , Keehn Brandon 
Published: January 2023

Abstract
The ability to image the dynamic electrical activity inside the brain tissues has profound implications for the understanding of cognition. This capability has been severely limited because of the difficulty in estimating these time-dependent volumetric fields from electroencephalography (EEG) data acquired on the surface of the skull. In this work we present the first method capable of accomplishing this with a high level of statistical evidence. The method employs a novel theory for brain wave propagation to reconstruct and map the fast-varying electric field distributions within the brain with high spatial and temporal resolution. The method is demonstrated in application to a condition of significant scientific and social importance, autism spectrum disorder (ASD), for which spatially resolved frequency dependent cognitive net- work anomalies are revealed.
Efficacy and safety of ultrasonography guided transperineal percutaneous laser ablation for treating benign prostatic hyperplasia: a randomized controlled trial
Authors: Chen Lei , Zhang Wei , Meng Zheying , Guo Qian , Cao Nailong , Xu Yanjun , Fu Qiang , Hu Bing 
Published: January 2023

Abstract
BACKGROUND: Transperineal percutaneous laser ablation (TPLA) has been proved a feasible and minimally invasive treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). However, the comparison with other therapeutic options, in particular transurethral resection of the prostate (TURP), the most widely used and gold standard surgical method for BPH patients, remained absent.
METHODS: Totally 51 BPH patients treated between 6/2019 and 12/2021 who had maximum urinary flow rate (Qmax) ≤15 mL/s and international prostate symptom score (IPSS) ≥8 were enrolled and randomly assigned to TURP or TPLA group at the ratio 1:1. TPLA was conducted with Esaote MyLab Twice equipped with flexible optical fiber, and TURP was performed by Olympus UES-40 SurgMaster System under standard procedure. The results were compared at 1, 3, 6 and 12 months after the operation. The efficacy endpoints included IPSS, Qmax, quality of life (QoL), European questionnaire-five dimensions (EQ-5D), residual urine volume (RUV), international index of erectile function-5 (IIEF-5) and ejaculatory dysfunction score. The safety endpoints included the incidence of complications, blood loss, visual analogue score (VAS) of pain, and catheter indwelling time.
RESULTS: The IPSS decreased by 14.17±6.13 at 3 months after TPLA, and by 13.19±5.86 after TURP (P=0.706). The complication rate of TPLA and TURP was 16% and 19.23% respectively (P=0.811).TPLA proved less Intraoperative blood loss (6.84±3.1mL,P＜0.001) and better ejaculatory protection within 6 months (P＜0.05). TURP has advantages in catheter indwelling time(P=0.012) and Qmax within 6 months(P＜0.05).
CONCLUSIONS: TPLA is comparable to TURP in the symptom relief of BPH patients, and with shorter operation time, less invasiveness and better protection, which may be more suitable for patients intolerant to TURP, or with underlying diseases such as anemia.
Role of Technology in Determining Financial Improvement in Sub Saharan Africa
Authors: Adeyemi Adeyinka Emmanuel , David Oladipo Olalekan 
Published: January 2023

AbstractDue to scanty literature on the impact of technology on financial development in Sub-Saharan Africa via ICT, one can't help but wonder: how can technology influence the financial system in Sub-Saharan Africa? And which of the components of technology is a determining factor of financial development in this region? Using generalized method of moments (GMM) estimations to identify relationships between variables, this study examines the impact of technology on financial development in Sub-Saharan African countries from 2000 to 2021. By proving that fixed telephone services have an equalizing effect on financial development, the study adds to the body of knowledge on financial development. Mobile cellular subscriptions have also been shown to have a financial development equalizing effect. On the other side, secure internet servers have a negative equalizing effect on financial development. In order to focus resources into financial system growth, regulations aiming at upgrading fixed telephone services, mobile cellular subscriptions, and secure internet servers should be supported.
Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury
Authors: Yao Xin-Qiang , Chen Jia-Ying , Yu Zi-Han , Huang Zu-Cheng , Hamel Regan , Liu Jun-Hao , Shen Xing , Wang Yong-Er , Zeng Yong-Qiang , Huang Zhi-Ping , Lu Yan-Meng , Zhou Zhi-Tao , Liu Cui-Ting , Shi Jun-Min , Peruzzotti-Jametti Luca , Pluchino Stefano , Zhu Qing-An , Chen Jian-Ting 
Published: January 2023

Abstract
Lipid metabolism is a critical process that occurs in the lipid-rich spinal cord during damage and repair. Here, we integrated ultrastructural characteristics with multi-omics analysis as well as transcriptomic, untargeted, targeted proteomic, lipidomic, and N6-methyladenosine (m6A) epitranscriptomic profiling in a clinically relevant spinal cord injury (SCI) model. We observed lipid accumulation, lysosome-based autophagy of lipid droplets, and remyelination in the lesion of the chronic phase. The analysis also revealed molecular alterations associated with the enhancement of glycolysis, tricarboxylic acid cycle, and fatty acid metabolism, marked increases in triglyceride species with C16:0 fatty acyl chains, and adaptive changes in cholesterol metabolism. These changes included decreased uptake of cholesterol through Mylip upregulation, decreased synthesis through downregulation of Fdps and Hmgcs1, and increased efflux through Apoe upregulation. Among these, Mylip and Hmgcs1 are regulated by m6A methylation. Altogether, our ﬁndings revealed endogenous mechanisms in response to microenvironment changes, highlighting the potential of exploring lipid regulators for SCI treatment.
The Use of Social Media in Learning English Writing
Authors: Puspita Dewi Aprilia Elok 
Published: January 2023

As technology grows rapidly, social media has become one inseparable element of the daily life of modern society. Its impacts have spread into every aspect of human life, including education. The use of social media in teaching and learning activities has brought a new contribution to education, especially in language learning. Using social media, people from different countries can find it easier to communicate with each other to exchange or learn languages together, such as English. As a global language, English has four skills to be mastered to get to the proficiency level. They are reading, listening, speaking, and writing. Among all the four skills, writing is considered to be the most complex one. As social media has brought much easiness and is very simple to use, utilizing social media to help the learning writing is considered to be helpful to help improve the effectiveness. Therefore, this article tried to uncover the use of social media in learning English writing.
Identifying the Mechanisms and Molecular Targets of Guchang Zhixie
Pills on Ulcerative Colitis: Coupling Network Pharmacology with GEO
Database and Experiment Verification
Authors: Wang Weihao , Song Xujiao , Ding Shanshan , Chen Chunlin , Ma Hao 
Published: January 2023

Objective:
This research investigates the mechanisms and molecular targets of the
Guchang Zhixie pill (GCZXP) against ulcerative colitis (UC) in silico and in vivo.

Methods:
The compounds and related targets of GCZXP were collected from the traditional Chinese
medicine systems pharmacology database. UC targets were from Gene Expression Omnibus
and GeneCards databases. Hub genes were acquired through Cytoscape. Gene ontology and Kyoto
Encyclopedia of Genes and Genomes enrichment were performed in the David database. R packages
were used to investigate the relationship between immune cells and hub genes and the diagnostic
model. AutoDock was used to verify the molecular docking of the core compounds and hub genes,
as well as nuclear factor-kappa B (NF-κB) p65 and IκBα. The hub genes and NF-κB pathway were
verified via experiment.

Results:
In GCZXP, a total of 51 active compounds were discovered. Enrichment analysis was used
to study inflammation, chemokine activity, NF-κB signalling pathway, etc. Thirteen key therapeutic
targets were involved, of which included three hub genes PTGS2, IL-1β and CXCL8. Immune infiltration
revealed that all of the 3 hub genes were positively correlated with M1 macrophages, neutrophils,
and activated memory CD4 cells, and negatively correlated with plasma cells. In the training
and validation sets, the area under the curve (AUC) of the diagnostic model developed by hub genes
reached 0.929 and 0.905, respectively, indicating a good forecasting potential. The rat experiment
proved that GCZXP significantly reduced the expressions of IL-1β, CXCL8, COX-2, and NF-κB
p65 while increasing IκBα and Bcl-2, alleviated colonic inflammatory injury and promoted ulcer
healing.

Conclusion:
GCZXP reduced the release of cytokines and regulated Bcl-2 in the treatment of UC
by inhibiting the NF-κB signalling pathway.
Understanding the Phytoestrogen Genistein Actions on Breast Cancer:
Insights on Estrogen Receptor Equivalence, Pleiotropic Essence and
Emerging Paradigms in Bioavailability Modulation
Authors: Malik Parth , Singh Raj , Kumar Mukesh , Malik Anuj , Mukherjee Tapan Kumar 
Published: January 2023

Abstract:
Prevalent as a major phenolic ingredient of soy and soy products, genistein is recognized as an eminent phytoestrogen owing to its interacting ability with estrogen receptors (ERs). The met-abolic conversion of plant-derived genistin to genistein by gut microbes and intestinal enzymes en-hances its absorption at intestinal pH of ~7.5-7.8. Genistein interferes in breast cancer (BC) devel-opment via pleiotropic actions on cell proliferation, survival, angiogenesis, and apoptosis. Though multiple investigations have demonstrated genistein intake-driven reduced BC risk, similar efficacy has not been replicated in clinical trials. Furthermore, multiple studies have structurally and func-tionally equated genistein extents with 17-β-estradiol (E2), the most available physiological estro-gen in females, culminating in aggravated BC growth. Of note, both genistein and E2 function via interacting with ERs (ERα and ERβ). However, although E2 shows almost equal affinity towards both ERα and ERβ, genistein shows more affinity towards ERβ than ERα. Our cautious literature survey revealed typical intake mode, ER expression pattern and the ratio of ERα and ERβ, transac-tivators/regulators of ERα and ERβ expression and activities, patient age, and menopausal status as decisive factors affecting genistein BC activities. Of further interest are the mechanisms by which genistein inhibits triple-negative breast cancers (TNBCs), which lack ERs, progesterone receptors (PRs), and human epidermal growth factor receptors (HER2). Herein, we attempt to understand the dosage-specific genistein actions in BC cells and patients with an insight into its better response via derivative development, nanocarrier-assisted, and combinatorial delivery with chemotherapeutic drugs.
Formulation Development and Evaluation of Apremilast Nanoemulgel for
Enhancing Permeability
Authors: Patel Neelam , Chaudhary Sunita , Chaudhary Ankit 
Published: January 2023

Background:
Oral apremilast, a selective phosphodiesterase-4 inhibitor, is effective in the
treatment of moderate to severe plaque psoriasis and acute psoriatic arthritic disease. According to
BCS categorization, it is a class IV medication, which denotes low solubility and lesser permeability
through the skin.

Objective:
The objective of the research is to develop a nanoemulsion that will increase apremilast’s
skin permeability. Utilizing a simplex lattice design, an optimised nanoemulsion has been developed,
and then transformed into a gel form and created as a nanoemulgel.

Method:
The nanoemulsion was developed by selecting the oil, surfactant, co-surfactant, and cosolvent,
in that order, based on the solubility study, and was then evaluated based on various criteria.
Different grades and concentrations of carbopol polymer were used to make nanoemulgel, which was
then tested for physicochemical parameters like pH, viscosity, spreadability, extrudability, percentage
of drug content, percentage of drug diffusion, skin permeation, and skin retention. For skin irritancy
tests, male Wistar albino rats weighing between 200 and 250 g were used to find out how likely it was
that apremilast-loaded nanoemulgel would cause skin irritation.

Result:
The nanoemulsion formulation A5 containing 10% Captex 355 and 40% Smix in a 3:1 ratio
of Cremophore RH 40: Labrafil showed the smallest particle size and greatest drug diffusion. In comparison
to other formulations of emulgel, the 0.75 % concentration of carbopol 940 produced the best
results.

Conclusion:
A stable nanoemulgel system with apremilast loaded was created, and a number of process
factors were assessed. The optimised batch produced repeatable results when evaluated, exhibited
no skin irritation, and was shown to be stable after three months at ambient conditions of temperature
and humidity.
Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/
ERK Signaling Pathway
Authors: Li Bo , Zhang Shengsheng , Song Jin , Xu Xiaolong , He Shasha , Wang Ning , Bai Yunjing , Chen Zhaoxia 
Published: January 2023

Background:
Myristicin is a type of natural compound showing anti-proliferative, anti-microbial,
and anti-inflammatory effects. However, its role in gastric cancer treatment remains unknown.

Objective:
In this study, the effect of myristicin on gastric cancer as well as its underlying mechanism
was investigated.

Methods:
Human gastric cancer cells were exposed to various concentrations of myristicin (0, 7.8125,
15.625, and 31.25 μM) for 48 h. Then CCK-8, fluorescence-activated cell sorting, and Hoechst staining
were performed to evaluate the cell proliferation and apoptosis. The levels of proteins associated with
cell cycle, apoptosis, endoplasmic reticulum (ER) stress, and EGFR/ERK signaling pathway were detected
by western blot. JC-1 staining was conducted to determine the mitochondrial membrane potential.
On the other hand, the effect of myristicin on gastric cancer growth and apoptosis was also determined
in vivo.

Results:
Myristicin retarded proliferation and induced ER stress and apoptosis in gastric cancer cells,
with decreased expression of cyclins, increased Bax expression, activated caspases, and enhanced cytochrome
C release and mitochondrial ROS. Furthermore, the EGFR/ERK signaling pathway was restrained
by myristicin. In addition, EGFR over-expression abolished the inhibitory function of myristicin
on proliferation, apoptosis, and ER stress. Also, myristicin inhibited the growth of gastric cancer cells as
well as the EGFR/ERK signaling pathway in vivo.

Conclusion:
Myristicin exerts an anti-cancer effect on gastric cancer cells by restraining the EGFR/ ERK
signaling pathway. It may have the potential to be applied as a novel drug in gastric cancer treatment.