bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple semi-automated home-tank method and procedure to explore classical associative learning in adult zebrafish
Authors: Buatois Alexis , Siddiqi Zahra , Naim Sadia , Marawi Tulip , Gerlai Robert 
Published: February 2023

AbstractThe zebrafish is a laboratory species that gained increasing popularity the last decade in a variety of subfields of biology, including toxicology, ecology, medicine, and the neurosciences. An important phenotype often measured in these fields is behaviour. Consequently, numerous new behavioural apparati and paradigms have been developed for the zebrafish, including methods for the analysis of learning and memory in adult zebrafish. Perhaps the biggest obstacle in these methods is that zebrafish is particularly sensitive to human handling. To overcome this confound, automated learning paradigms have been developed with varying success. In this manuscript, we present a semi-automated home tank-based learning/memory test paradigm utilizing visual cues, and show that it is capable of quantifying classical associative learning performance in zebrafish. We demonstrate that in this task, zebrafish successfully acquire the association between coloured-light and food reward. The hardware and software components of the task are easy and cheap to obtain and simple to assemble and set up. The procedures of the paradigm allow the test fish to remain completely undisturbed by the experimenter for several days in their home (test) tank, eliminating human handling or human interference induced stress. We demonstrate that the development of cheap and simple automated home-tank-based learning paradigms for the zebrafish is feasible. We argue that such tasks will allow us to better characterize numerous cognitive and mnemonic features of the zebrafish, including elemental as well as configural learning and memory, which will, in turn, also enhance our ability to study neurobiological mechanisms underlying learning and memory using this model organism.
FORMULASI SEDIAAN BEDAK DINGIN EKSTRAK ETANOL 96% HERBA SELEDRI (Apium graveolens L.) SEBAGAI ANTIBAKTERI Propionibacterium acnes
Authors: Sofi Nurmay Stiani  , Agnes Syafera  , Afifah Nur Shobah  
Published: February 2023

Jerawat muncul ketika terjadi penyumbatan folikel polisebasea yang menyebabkan sebum terhambat untuk keluar dan mengalami inflamasi. Peradangan dapat disebabkan salah satunya oleh bakteri Propionibacterium acnes. Ekstrak etanol herba seledri diketahui memiliki senyawa fitokimia yaitu alkaloid, saponin, flavonoid, dan tanin yang memiliki efek sebagai antibakteri. Untuk kemudahan aplikasi saat pengobatan jerawat dari ekstrak etanol 96% herba seledri diformulasikan menjadi bedak dingin yang praktis dalam penggunaannya. Penelitian ini bertujuan untuk memformulasikan sediaan bedak dingin ekstrak etanol 96% herba seledri, dengan variasi konsentrasi untuk mengetahui aktivitas antibakteri sediaan bedak dingin untuk mengatasi bakteri Propionibacterium acnes. Riset ini adalah riset laboratorium menggunakan 3 kelompok uji dan 3 kelompok untuk kontrol. Perlakukan dari konsentrasi 22,5%; 33,75%; 45% dan kontrol negatif adalah basis bedak dingin, clindamycin dan kontrol positif (bedak bermerek). Pengujian antibakteri menggunakan metode difusi cakram Kirby-Bauer dan diamati diameter zona hambat. Hasil penelitian menujukkan bahwa bedak dingin sesuai dengan persyaratan uji homogenitas, uji pH (4,5-6,5), uji kadar air ?10%, stabilitas pada F 1 dan F2, namun untuk F3 pada uji stabilitas tidak masuk dalam persyaratan karena mengalami perubahan warna. Uji aktivitas antibakteri bedak dingin ekstrak etanol herba seledri dengan konsentrasi 22,5% memiliki rata-rata diameter zona hambat 16,5 mm, konsentrasi 33,75% yaitu 2,5 mm dan konsentrasi 45% tidak ada zona hambat. Penelitian ini menujukkan ekstrak etanol etanol 96% herba seledri (Apium graveolens L.) dapat diformulasikan menjadi sediaan bedak dingin dengan variasi konsentrasi, sediaan bedak dingin ekstrak etanol 96% herba seledri (Apium graveolens. L) pada konsentrasi 22,5% yang efektif dalam menghambat pertumbuhan bakteri Propionibacterium acnes ...
ASSESSMENT OF NOISE IMPACT OF AIRCRAFT OPERATIONS AROUND PODGORICA AIRPORT
Authors: Lukačević Nikola , Ganić Emir , Mirković Bojana 
Published: February 2023

Abstract:This paper analyses impact of aircraft noise on community around Podgorica Airport, Montenegro. The airport is located 12 km from the city centre of the Montenegro capital, Podgorica. It served 1.3 million passengers and 7.5 thousand operations in 2019. The noise impact assessment is conducted in IMPACT web-based modelling platform using the distribution of operations by aircraft types, time of the day, and radar tracks for the busiest day (August 15) in 2019. Noise contours are assessed for Lden and Lnight indicators. They were merged with the Global Human Settlement Layer to assess the number of people exposed to different noise levels. In addition, based on the World Health Organization recommended exposure levels related to their health implications, the percentages of the population highly annoyed and highly sleep-disturbed are estimated. Furthermore, facilities of public importance (schools, hospitals, churches, etc.) are assessed against compatibility with the requirements set for the Zones with increased noise protection in national regulations. The results show that the exposure of community around Podgorica Airport to aircraft noise is still not a serious issue. The near vicinity of the airport is industrial zone and the number of people highly annoyed by noise is approximately 3.2% of the total city population. Nevertheless, it is crucial to draw attention to planners to preserve airport neighbourhood from potential inhabiting, to avoid problems that some airports in the region are facing nowadays.
Response of Integrated Nutrient Management (INM) on Growth, Yield, and Nutrient use Efficiency of Wheat under Irrigated Conditions
Authors: Ahmed Maqbool , Hyder Syed Ishtiaq , Ullah Atiq , Khan Raza Ullah , Ahmad Muhammad Adeel , Hayat Asim , Arshad Nadeem 
Published: February 2023

To feed Pakistan's rapidly growing population, wheat productivity must be increased through balanced nutrition. Chemical fertilizer prices are rising and there is low nutrient use efficiency, as well as excessive or imbalanced use of chemical fertilizers. Integrated nutrient management treatments -the use of bio-fertilizer plus inorganic fertilizers-is a promising technology that not only increases crop yield, nutrient use efficiency. A field experiment was conducted at Naseerabad (Baluchistan) to assess the effect of (bio-fertilizer, inorganic fertilizers including Zn plus Boric Acid) on wheat crop production and nutrient use efficiency under irrigated conditions. A randomized complete block design was used to arrange the treatments (RCBD). Comprised with four treatments (INM NPK@120:9 0:60 kg/ha-1 Zn 5 kg, Boric acid 1 Kg/ha-1) FP treatment NP@75:50 kg/ha-1RDFtreatment.NPK,100.80.50 kg/ha-1and control treatment. This bio fertilizer plus chemical fertilizer significantly improves wheat growth parameters such as plant height, number of grains spiked, straw, and grain yield. Similarly, integrated nutrient management technology significantly increased N, P, K uptake in wheat grain content while increasing nutrient use efficiency. The highest grain yield was recorded (4.9 t/ha-1) in integrated nutrient management treatments with 120 kg N, 90 kg P, 60 kg K, 5 kg Zn, and 1 kg B ha-1 combined with bio-fertilizer plus farmyard manure. It resulted in a 25% increase over farmer practice (FP) and a 9% increase over the RDF treatment. The use of balance fertilizer in wheat resulted in significantly increased the wheat crop yield also improved agronomic parameters
Why Do Chromospheric Oscillations in Sunspot Umbrae Appear to Propagate Downward?
Authors: Chae Jongchul , Lim Eun-Kyung , Lee Kyeore , Kwak Hannah , Lee Kyoung-Sun , Kang Juhyung , Kang Soosang 
Published: February 2023

Abstract
Umbral oscillations constitute the most noticeable chromospheric feature of sunspot umbrae—large-amplitude oscillations of intensity (umbral flashes, if very strong) and line-of-sight velocity, with periods of about 3 minutes. These umbral oscillations are usually interpreted as acoustic waves propagating upward under the effect of gravity. However, there have been observational reports that intensity peaks tend to occur in downflowing phases of umbral oscillations, and this appears to be more compatible with downward propagation. We investigate whether this intensity–velocity correlation occurs persistently or not, by determining the vertical flux of the wave energy, based on Hα line measurements of the temperature and velocity. As a result, we find that the wave flux is persistently negative in sunspot umbrae, confirming the discrepancy specified above. We attribute this discrepancy to the nonzero fluctuation of net radiative heating. We find that when this effect is taken into account in the energy equation, the pressure is peaked during upflowing phases, being compatible with the notion of upward propagation. We conclude that temperature (and intensity) peaks occur during downflowing phases, not because of downward propagation, but because of radiative heat transport.
Du Tiers-Monde aux Mondes en développement : itinéraire d’une revue (1973-2022)
Authors: Gérardin Hubert 
Published: February 2023

50 ans de publications. Des conseils de rédaction et des équipes éditoriales qui se sont succédées dans la continuité, rassemblant plusieurs centaines de chercheurs et enseignants-chercheurs. Des institutions qui ont tour à tour porté la revue et des éditeurs qui l’ont publié sous forme papier, puis électronique, en toute confiance. Des milliers de collègues qui ont accepté de mettre leurs connaissances et compétences au service de l’expertise et de la finalisation des textes scientifiques reçus par la revue. En 2023, plus de 1 000 institutions abonnées en ligne de par le monde. Plus de 50 000 connexions de lecteurs en institutions chaque année pour des articles accessibles en ligne depuis le numéro 113/114 sur le bouquet de revues Cairn. Ce volumineux numéro permet de revenir sur l’histoire de la revue (partie 1), couplée à celle des études sur le développement (partie 2).
Mondes en développement : analyse lexicale de 50 ans d’histoire
Authors: Boidin Bruno , Cordrie Benjamin , Figuière Catherine 
Published: February 2023

La revue Mondes en développement fête ses cinquante ans. Une analyse lexicale permet de brosser le tableau de son évolution. F. Perroux a fondé la revue et demeure l’un des plus gros contributeurs aux côtés de R. Gendarme, H. Gérardin ou encore Ph. Hugon. L’Afrique reste la zone d’étude privilégiée par les auteurs. Le développement durable s’invite dans les sommaires des années 2000, et les « pays émergents » remplacent de plus en plus souvent les « pays en voie de développement ». 200 numéros plus tard, Mondes en développement reste fidèle à son projet originel : une revue francophone pluraliste sur le développement. Classification JEL : A3, O1, Y1
Developing entrustable professional activities for family medicine training in South Africa
Authors: Jenkins Louis S. , Mash Robert , Motsohi Ts'epo , Naidoo Mergan , Ras Tasleem , Cooke Richard , Brits Hanneke 
Published: February 2023

Workplace-based assessment (WPBA) is becoming part of high-stake assessments in specialist training. Entrustable professional activities (EPAs) are a recent addition to WPBA. This is the first South African publication on developing EPAs for postgraduate family medicine training. An EPA is a unit of practice, observable in the workplace, constituting several tasks with underlying knowledge, skills and professional behaviours. Entrustable professional activities allow for entrustable decisions regarding competence in a described work context. A national workgroup representing all nine postgraduate training programmes in South Africa has developed 19 EPAs. This new concept needs change management to understand the theory and practice of EPAs. Family medicine departments with large clinical workloads are small, necessitating navigating logistical issues to develop EPAs. It has unmasked existing workplace learning and assessment challenges.Contribution: This article contributes new thinking to developing EPAs for family medicine in an effort to understand more authentic WPBA nationally.
Comparative Study of Bupivacaine-Fentanyl versus Ropivacaine-Fentanyl for Epidural Analgesia in Labor
Authors: Bhatia Upasna , Shah Vandana , Soni Ekta S , Bajaj Manan , Patel Kirti D , Pandya Charu J , Vasaiya Harish 
Published: February 2023

Background:
Labor pain is one of the most intense pains that a woman experiences. Almost 60% of primiparous women described the pain of uterine contractions as unbearable extremely severe or excruciating.

Aims:
Our study aimed to relieve pain suffering of mother and to decrease fetal acidosis to make the delivery process safer for mother and baby.

Settings and Design:
Thus, epidural labor analgesia was designed comparing ropivacaine-fentanyl (RF) and bupivacaine-fentanyl (BF) as intermittent bolus technique.

Materials and Methods:
Sixty women who requested epidural analgesia having ≥3 cm cervical dilatation were allocated in two groups, one group received RF and the other group received BF. Each group received study drug 16 mL with 50 μg fentanyl and top of 10 mL and 25 μg fentanyl when visual analog scale (VAS) ≥3. The efficacy of analgesia, adverse effects, and obstetric and neonatal outcomes were compared.

Statistical Analysis:
For skewed data or ordered categorical data, nonparametric Mann–Whitney U-test was used for statistical analysis of two groups. For categorical data, comparisons were made by Pearson's Chi-square test or Fisher's exact test as appropriate (%).

Results:
Both groups were comparable in terms of demographic data and obstetric and neonatal parameters at the onset of labor Comparison of heart rate, systolic blood pressure (BP), diastolic BP, and saturation between Group RF and Group BF. It was found statistically not significant. VAS score before the epidural study drug was given, was 5 (4–5) in RF group, and was 5 (3–6) in BF group, and after 1 min, VAS score was 1 in both the groups thereafter. The score remained zero till at 100 min in both the groups till the time when the top-up dose was given. Bearing down reflex was present in all the patients as judged by the obstetrician. It was sluggish in 20% of patients in Group RF as compared to 10% in Group BF.

Conclusions:
From clinical and safety perspective, both RF and BF were reasonable choice for labor analgesia.
The Long-Term Impact of a Holistic Inpatient Treatment Program for Substance use Disorders: 498 Patients Personally Revisited after 5-10 Years
Authors: Singh Rajinder , Mahintamani Tathagata , Singh Onkar , Gupta Nand Lal , Kashyap Deepti 
Published: February 2023

Abstract

Background:
Holistic treatment often better impacts recovery from substance use disorder (SUD) in terms of treatment retention and psychosocial improvement. Studies on the long-term outcome of such treatment programs are needed from India.

Materials and Methods:
We traced and interviewed 498 patients face to face after 5–10 years from their last inpatient treatment with holistic approach in a rural addiction treatment center in Punjab. We used a semi-structured questionnaire for the assessment of various clinical, social, and behavioral parameters. Patients were asked about their experience during inpatient treatment and treatment modalities, and qualitative assessment was performed by content analysis.

Results:
The mean age of onset was 21.1 ± 7 years, and the mean duration of dependence was around 10 years. At the final assessment, 33% of the patients had relapsed, 32% were abstinent, 27% were abstinent with intermittent lapses, and the rest of them died. Intergroup comparison revealed that with respect to the relapsed group, abstinent patients had more regular follow-up (χ2
= 52.8, P < 0.001), physical exercise (χ2
= 50.5, P < 0.001), social interaction (χ2
= 11.4, P = 0.02), better marital relationship (χ2
= 202.5, P < 0.001), participation in household works (χ2
= 159.5, P < 0.001), and more favorable rating of the treatment center (χ2
= 70.4, P < 0.001). The majority of satisfied patients felt that overall good facility and service during inpatient treatment helped in their recovery.

Conclusion:
There was an overall improvement in psychosocial functioning in the abstinent patients after the holistic treatment. The positive changes are persistent after an interval of around 5 to 10 years. The inadequate treatment utilization of the relapsed group requires attention and redressal.
Relationship of Mindfulness with Depression, Self-Management, and Quality of Life in Type 2 Diabetes Mellitus: Mindfulness is a Predictor of Quality of Life
Authors: Patra Suravi , Patro Binod Kumar , Padhy Susanta Kumar , Mantri Jogamaya 
Published: February 2023

Abstract

Context:
Mindfulness interventions have shown promising results in both psychological and clinical outcomes of type 2 diabetes mellitus. Depression, self-management, and quality of life (QOL) have shown improvement with mindfulness interventions; however, little is known about dispositional mindfulness and its relationship with depression, self-management, and QOL in type 2 diabetes mellitus.

Aims:
The aim of this study is to assess the relationship of dispositional mindfulness with depression, self-management, and QOL in patients of type 2 diabetes.

Settings and Design:
Noncommunicable disease outpatient department of a tertiary care medical center of East India. Cross-sectional study.

Subjects and Methods:
Ninety-nine patients with type 2 diabetes completed the Five Facets Mindfulness Questionnaire, Diabetes Self-Management Questionnaire, and World Health Organization QOL BREF questionnaire and Hamilton Rating Scale for depression.

Statistical Analysis Used:
Pearson’s correlation and hierarchical regression analysis using the SPSS software version 20.0.

Results:
Describing, acting with awareness, and nonjudging facets of mindfulness showed a negative correlation with depression (P < 0.05). Acting with awareness and nonreactivity to inner experience were positively correlated with the physical activity domains of self-management (P < 0.05). All facets of mindfulness showed a positive correlation with four domains of QOL. In hierarchical regression analysis, after controlling for sociodemographic and clinical variables, mindfulness predicted the psychological domain of QOL, explaining 31% of the variance (P ≤ 0.001). However, mindfulness did not predict depression or self-management.

Conclusions:
Dispositional mindfulness is a strong predictor of QOL in type 2 diabetes mellitus and hence can be targeted with interventions to improve psychological outcomes.
The Sensitivity and Specificity of Electrocardiogram in Localizing the Culprit Artery with Angiographic Correlation in Indian Patients with Acute St-Segment Elevation Myocardial Infarction
Authors: Joseph Jacob , Menon Jaideep C. 
Published: February 2023

Abstract

Background:
A detailed analysis of electrocardiogram (ECG) patterns may help in the identification of the precise site and location of coronary artery occlusions and guide the selection of an appropriate clinical therapeutic strategy in patients with myocardial infarction (MI).

Aim:
This study was conducted to evaluate the sensitivity and specificity of prespecified ECG criteria in localizing the culprit artery in acute ST-segment elevation myocardial infarction (STEMI) and to correlate the ECG findings with coronary angiogram.

Methods:
Patients with acute STEMI aged ≥l8 years, diagnosed by ECG and who underwent angiography, were included for analysis. The infarct-related artery was identified with prespecified ECG criteria and the measure of agreement kappa was calculated to find the correlation between ECG findings and coronary angiogram.

Results:
Of 118 patients, anterior wall myocardial infarction (AWMI) was more common than inferior wall myocardial infarction (IWMI) (56% vs. 46%). In AWMI, ST-elevation ≥2.5 mm in V1 and ST-elevation in augmented Vector Left (aVL) had high sensitivity for detecting occlusion proximal to S1 and D1. High correlation with the angiogram was observed with ST-elevation in aVL, V1 for occlusion proximal to S1 and D1 (κ = 0.531; P = 0.000). In IWMI, ST-elevation in lead III > II and ST-elevation ≥1 mm in II, III, augmented Vector Foot (aVF) had maximum sensitivity in detecting occlusion in proximal and distal right coronary artery (RCA). High correlation with the angiogram was observed with ST-elevation in lead III > II (κ = 0.438; P = 0.000) and ST-coving without ST-elevation in RV4 (sensitivity = 79%, κ = 0.402; P = 0.002) for occlusion in the RCA. Ratio of S:R waves amplitude in aVL ≤3 and ST-depression ≥0.5 mm V1-V3 were 100% sensitive for occlusion in the left circumflex (LCx). Strong correlation with the angiogram was observed with ST-elevation ≥0.5 mm V7–V9 for occlusion in LCx (sensitivity = 94%, κ = 0.743; P = 0.000).

Conclusion:
ECG in patients with STEMI is valuable and can reliably predict the culprit artery in these patients prior to angiography.
Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve
Authors: Sathyamurthy Immaneni , Satish Sai 
Published: February 2023

Abstract
Transcatheter aortic valve replacement (TAVR) is being routinely done in various centres for aortic stenosis due to tricuspid aortic valves. The number of TAVR procedures are increasing, but the data on bicuspid aortic valves (BAV) is scanty. BAV is commonest abnormality in general population and can progress to severe aortic stenosis. BAVs are a heterogeneous group due to anatomical variations and these valves are large, elliptical with asymmetric calcification. Echocardiography, multidetector CT scans help in diagnosing various phenotypes and in pre TAVR work up in sizing the device. The major issues regarding TAVR in BAVs are improper deployment of the valve, increased risk of strokes, paravalvular leaks, need for second device and requirement for pacemakers. With new generation devices the complication rates are coming down indicating their safe usage in BAVs. Data from TAVR registries and published studies have shown the applicability of TAVR in BAVs with acceptable outcomes.
Simultaneous Presence of Atrial Arrhythmia and Hypocalcemia in Dilated Cardiomyopathy
Authors: Singhi Anil Kumar , Mukherjee Sanjeev S. , Kumar K. H. Shine , Kumar Raman Krishna 
Published: February 2023

Abstract
Dilated cardiomyopathy in young children has varied etiological factors. Some cases have correctable causes such as incessant arrhythmia, correctable metabolic abnormality, and left ventricular obstructive lesions. Two 4-month-old infants presented with severe left ventricular dysfunction and ectopic atrial tachycardia. Biochemical profile of the infants showed low ionic and total calcium, elevated serum phosphate, elevated alkaline phosphatase, and elevated serum lactate. The parathyroid hormone was elevated and 25-hydroxyvitamin D3 was reduced. The patients were treated with beta-blocker, calcium, and Vitamin D supplementation, along with antifailure therapy. The tachycardia resolved over a 12-h period and calcium normalized in the next few days. The left ventricular function returned to normal over a 5–16-month period. In 6–8 years of follow-up, patients were in sinus rhythm doing very well with normal cardiac function with normal calcium-related biochemical parameters. The presence of incessant atrial arrhythmia in a case of hypocalcemic cardiomyopathy is rare and can have link with hypocalcemia-induced electrical changes in the cardiomyocyte in selected cases. Thorough and protocol-based treatment approach helps in correct diagnosis and treatment. Further study and molecular research can shed more light on the complex interaction of hypocalcemia and arrhythmia.