bluuebunny/crossref_metadata_2025_split huggingface dataset:
Escalating spread of SARS-CoV-2 infection after school reopening among students in hotspot districts of Oromia Region in Ethiopia: Longitudinal study
Authors: Gobena Dabesa , Kebede Gudina Esayas , Yilma Daniel , Girma Tsinuel , Gebre Getu , Gelanew Tesfaye , Abdissa Alemseged , Mulleta Daba , Sarbessa Tarekegn , Asefa Henok , Woldie Mirkuzie , Shumi Gemechu , Kenate Birhanu , Kroidl Arne , Wieser Andreas , Eshetu Beza , Degfie Tizta Tilahun , Mekonnen Zeleke 
Published: February 2023

Background
COVID-19 pandemic caused by extended variants of SARS-CoV-2 has infected more than 350 million people, resulting in over 5.5 million deaths globally. However, the actual burden of the pandemic in Africa, particularly among children, remains largely unknown. We aimed to assess the seroepidemiological changes of SARS-CoV-2 infection after school reopening among school children in Oromia, Ethiopia.

Methods
A prospective cohort study involving students aged 10 years and older were used. A serological survey was performed twice, at school reopening in December 2020 and four months later in April 2021. Participants were selected from 60 schools located in 15 COVID-19 hotspot districts in Oromia Region. Serology tests were performed by Elecsys anti-SARS-CoV-2 nucleocapsid assay. Data were collected using CSentry CSProData Entry 7.2.1 and exported to STATA version 14.2 for data cleaning and analysis.

Results
A total of 1884 students were recruited at baseline, and 1271 completed the follow-up. SARS-CoV-2 seroprevalence almost doubled in four months from 25.7% at baseline to 46.3% in the second round, with a corresponding seroincidence of 1910 per 100,000 person-week. Seroincidence was found to be higher among secondary school students (grade 9–12) compared to primary school students (grade 4–8) (RR = 1.6, 95% CI 1.21–2.22) and among those with large family size (> = 5) than those with a family size of <3 (RR = 2.1, 95% CI 1.09–4.17). The increase in SARS-CoV-2 seroprevalence among the students corresponded with Ethiopia’s second wave of the COVID-19 outbreak.

Conclusion
SARS-CoV-2 seroprevalence among students in hotspot districts of the Oromia Region was high even at baseline and almost doubled within four months of school recommencement. The high seroincidence coincided with the second wave of the COVID-19 outbreak in Ethiopia, indicating a possible contribution to school opening for the new outbreak wave.
Associations of physical activity levels, and attitudes towards physical activity with blood pressure among adults with high blood pressure in Bangladesh
Authors: Islam Fakir M. Amirul , Islam Mohammad Ariful , Hosen Mohammad Arzan , Lambert Elisabeth A. , Maddison Ralph , Lambert Gavin W. , Thompson Bruce R. 
Published: February 2023

Background
Physical activity is important for the control of high blood pressure (hypertension). We aimed to investigate the associations of current physical activity levels, sedentary time, knowledge of and attitude towards physical activity with blood pressure in people with hypertension in a rural area in Bangladesh.

Methods
A total of 307 adults aged 30 to 75 years with hypertension were recruited from the Banshgram Union of Narial district as part of a cluster-randomized control trial. Current blood pressure was measured as the outcome variable. Associated variables included physical activity at work, travel to and from places, recreational activity, metabolic equivalent task (MET)-min, sedentary time, and awareness of and attitudes towards physical activity. Rasch analysis was used to compute a combined score from the five awareness of and attitudes towards physical activity items and categorized into 0–40 (towards negative attitude), 41–60 score (mixed attitude) and 61–100 (positive attitude). We used a generalised linear model to analyze the data.

Results
Participants (n = 68, 22.1%) who engaged in vigorous-intensity physical activity that causes large increases in breathing or heart rate like carrying or lifting heavy loads, digging or construction work for at least 10 minutes continuously had lower systolic blood pressure (SBP) (mean (95% confidence interval (CI)), 143.6 (140.1, 147.2)) compared to those who did not take part in a vigorous-intensity physical activity (mean (95% CI), 150 (147.6, 152.3)). MET-min less than 600 min/week was significantly associated with higher SBP 153.8 (148.1, 159.6) than MET-min 600–2999 min/week 148.0 (143.0, 152.9) and MET-min>3000 min/week 146.9 (144.5, 149.3), p = 0.001 for trend. Sitting time more than four hours a day was associated with higher DBP 91.4 (89.7, 93.0) compared to those who had sitting time less than fours a day 88.6 (87.1, 90.1). People with positive attitudes were associated with a reduced SBP of 10.6 (0.36, 20.8) mmHg and DBP 5.88 (0.47, 11.3) compared to the people who had a negative attitude towards taking part in physical activity.

Conclusions
Participating in high physical activity and positive attitudes towards physical activity were associated with lower blood pressure levels. Physical activity awareness programs should be implemented to increase awareness of health benefits and increase participation in high physical activity.
Efficacy and safety of GSK3772847 in participants with moderate-to-severe asthma with allergic fungal airway disease: A phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial
Authors: Akinseye Chika , Crim Courtney , Newlands Amy , Fairman David 
Published: February 2023

Introduction
Current treatments for allergic fungal airway disease are not specific for asthma and are associated with limited efficacy or safety concerns. This Phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial assessed the efficacy and safety of GSK3772847, an anti-interleukin-33 receptor monoclonal antibody, in moderate-to-severe asthma patients with allergic fungal airway disease (ClinicalTrials.gov: NCT03393806).

Methods
Key inclusion criteria required participants of ≥18 years of age with a documented diagnosis of moderate-to-severe asthma (≥12 months) treated with inhaled corticosteroid and long-acting β2-agonist (≥4 months); evidence of allergic fungal airway disease (fungal sensitization to Aspergillus fumigatus [>0.35 KU/L] or Penicillium chrysogenum [>0.35 KU/L] and no history of concurrent respiratory disease/recurrent or ongoing non-pulmonary infections. Participants were randomized (1:1) to GSK3772847 (10 mg/kg) or matching placebo intravenously administered at Weeks 0, 4, and 8, in addition to standard of care. Randomization was based on systemic anti-fungal treatment status at screening. Primary endpoints were change from baseline (Week 0) to Week 12 in blood eosinophils and fractional exhaled nitric oxide.

Results
Participants (n = 17) were randomized to GSK3772847 (n = 8) or placebo (n = 9) for 12 weeks and included in efficacy and safety analyses. This study was terminated early due to the high rate of screen failure, low enrollment, and unlikely feasibility of timely study completion. There were no differences observed in blood eosinophils or fractional exhaled nitric oxide between treatment arms. Target engagement was demonstrated by reductions in free soluble suppressor of tumorigenicity 2 levels in the GSK3772847 arm throughout the treatment period. No deaths occurred and no new safety signals were identified.

Conclusions
Lack of clinical benefits with GSK3772847 was likely due to the small sample size, highlighting the need for larger prospective studies.
The pre-anesthetic period is the best time to evaluate the knee flexion angle for predicting the flexion angle after total knee arthroplasty: A prospective cohort study
Authors: Ruangsomboon Pakpoom , Pornrattanamaneewong Chaturong , Santanapipatkul Polasan , Sarirasririd Sorarid , Chareancholvanich Keerati , Narkbunnam Rapeepat 
Published: February 2023

IntroductionKnee flexion angle (KFA) is one of the most critical factors for evaluating patient functional outcomes after total knee arthroplasty (TKA). Preoperative KFA and intraoperative drop leg test are both accepted as predictors of postoperative KFA after TKA. Preoperative testing performed after anesthesia helps overcome pain-related limitations; however, the KFA measurement timepoint that best predicts KFA at 6 months after TKA has not yet been established.MethodsThis prospective cohort study recruited patients who underwent unilateral primary TKA at Siriraj Hospital (Bangkok, Thailand) during August 2012 to August 2017. We recorded KFA at the pre-anesthetic phase, post-anesthetic phase, intraoperation using drop leg test, and at 6-months post-operation. Pearson’s correlation coefficient was used to evaluate correlation between different measurement timepoints and 6 months after surgery. Those same relationships were evaluated for overall patients, and for patients with KFA <90° (poor KFA), 90–120° (average KFA), and >120° (high KFA).ResultsA total of 165 patients with a mean age of 68.7 years were recruited. Pre-anesthetic KFA measurement had the highest positive correlation with the 6-month KFA (r= 0.771,p<0.05). Post-anesthetic measurement and intraoperative drop leg KFA measurement had moderate positive correlation (r= 0.561,p<0.05) and low positive correlation (r= 0.368,p<0.05) with the 6-month KFA, respectively. The average KFA group had the highest positive correlation between pre-anesthetic KFA measurement and the 6-month KFA (r= 0.711,p<0.05). Predicted 6-month KFA (degrees) adjusted for pre-anesthetic KFA is 45.378 + [0.596 x pre-anesthetic KFA (degrees)] (r = 0.67, p <0.05).ConclusionsPre-anesthetic KFA demonstrated the highest correlation with the final KFA at six months after unilateral primary TKA, especially in the patients who had a preoperative KFA within 90–120°.
Feasibility of gel-like radiopaque embolic material using gelatin sponge and contrast agent for tract embolization after percutaneous treatment
Authors: Nota Takehito , Kageyama Ken , Yamamoto Akira , Jogo Atsushi , Sohgawa Etsuji , Yonezawa Hiroki , Murai Kazuki , Ogawa Satoyuki , Miki Yukio 
Published: February 2023

Objectives
Tract embolization has been performed to prevent bleeding after trans-organ puncture. This study evaluated clinical outcomes of tract embolization using a gel-like radiopaque material comprising two sheets of gelatin sponge and 3 mL of contrast agent, and experimentally confirmed its viscosity and hemostatic efficacy.

Methods
Three study phases were planned. In a clinical setting, 57 consecutive patients who underwent tract embolization after transhepatic puncture were retrospectively analyzed. Clinical success was evaluated as absence of bleeding complications for 30 days after the procedure. In a basic experiment, viscosity of the material was analyzed. In an animal experiment, rabbit kidney puncture site was embolized via a 7-Fr sheath using this material, coils, or N-butyl-2-cyanoacrylate glue or received no embolization while removing the sheath. Amounts of tract bleeding were measured for 1 min and compared between groups.

Results
Embolization was successfully completed in all clinical cases. No postoperative bleeding requiring intervention was encountered. The basic experiment revealed the material was highly viscous. In the animal experiment, mean weights of bleeding in the control, gel-like embolic material, coil, and N-butyl-2-cyanoacrylate glue groups were 1.04±0.32 g, 0.080±0.056 g, 0.20±0.17 g and 0.11±0.10 g, respectively. No significant differences were seen among embolization groups, while the control group showed significantly more bleeding than any embolization group.

Conclusion
Tract embolization with this gel-like radiopaque embolic material appears safe and feasible.

Advances in knowledge
Tract embolization using this embolic material with two sheets of gelatin sponge and 3 mL of contrast agent offers a safe, feasible, and economical procedure after trans-organ puncture, because the material offers the following characteristics: visibility under X-ray; viscosity facilitating retention in the tract; ability to allow repeated puncture via the same route; and low cost.
Peace Movements in Islam: History, Religion, and Politics, Juan Cole (ed.) (2022)
Authors: Kayyali Abdul-Wahab 
Published: February 2023

Review of: Peace Movements in Islam: History, Religion, and Politics, Juan Cole (ed.) (2022)
London: I.B. Tauris (Bloomsbury Publishing), 224 pp.,
ISBN 978-0-75564-317-2, p/bk, $25.95
A Randomized, Double-Blind, Controlled Trial of Percutaneous Tibial Nerve Stimulation With Pelvic Floor Exercises in the Treatment of Childhood Constipation
Authors: Yu Zheng-tong , Song Jun-Min , Qiao Lei , Wang Yang , Chen Ying , Wang En-Hui , Zhang Shu-Cheng 
Published: February 2023

INTRODUCTION:
The management of childhood constipation is challenging. Pelvic floor dysfunction (PFD) is one of the most common causes of childhood constipation. Percutaneous tibial nerve stimulation (PTNS) with pelvic floor exercises (PFE) has achieved a satisfactory outcome in the elderly individuals and women with PFD. The efficacy of PTNS with PFE in childhood constipation has not been established.

METHODS:
A randomized, double-blind, controlled trial with 84 children who met the inclusion criteria was conducted. All participants were randomly assigned to PTNS with PFE or sham PTNS with PFE groups and received their individual intervention for 4 weeks with a 12-week follow-up evaluation. The spontaneous bowel movements (SBM) ≥3 per week were the main outcomes, and the risk ratio (RR) with 95% confidence interval (CI) were calculated. High-resolution anorectal manometry and surface electromyography were used for the assessment of pelvic floor function, and the adverse effects were assessed based on symptoms.

RESULTS:
At the end of the follow-up period, 26 patients (61.9%) in the PTNS with PFE group and 15 patients (35.7%) in the sham group had ≥3 SBM per week compared with baseline (net difference 26.2%, 95% CI 5.6%–46.8%; RR 2.750, 95% CI 1.384–5.466; P < 0.05). PFD remission occurred in 49 children, 33 (78.6%) in the PTNS with PFE group and 16 (38.1%) in the sham group (RR 2.063, 95% CI 1.360–3.128, P < 0.05). No adverse effects occurred.

DISCUSSION:
PTNS with PFE is a safe and effective method in the treatment of childhood constipation, particularly in children with PFD or dyssynergic defecation.
Iron Man: Non-HFE Hemochromatosis Without Significant Fibrosis
Authors: Chaudhry Hunza , Sohal Aalam , Petrosyan Arpine , Laput Gieric , Roytman Marina , Prajapati Devang 
Published: February 2023

ABSTRACT
Hemochromatosis is a genetic disorder marked by abnormally high levels of intestinal iron absorption leading to severe end-organ damage. It is classically associated with HFE gene mutations, including C282Y and H63D, but in recent years, many non-HFE mutations along with novel variants have been discovered, particularly among non-Whites. We describe a case of an elderly Japanese patient who was evaluated for markedly elevated ferritin found to have hemochromatosis, with no hepatic fibrosis while being negative for HFE and common non-HFE gene mutations.
Combined Repair of Upper Sternal Cleft and Pectus Excavatum in a Child
Authors: Çelik Sezai , Erşen Ezel 
Published: February 2023

Abstract
Sternal cleft accompanied by pectus excavatum is a rare type of congenital anomaly of the chest wall. Surgical correction is a suitable approach to restore the heart, large vessels, and respiratory dynamics early. This is a report of the successful surgical correction of upper sternal cleft anomaly accompanied by pectus excavatum in a child. The pectus excavatum was corrected without the use of any prosthesis. The cleft was closed by primary approximation with enough dissected pectoralis major muscle and partial thymectomy, mobility, and flexibility ensured by pectus correction. The integrity of the sternum and the chest wall was normal at the end of the 12-month follow-up period.
Same-Day Carotid Artery Stenting and Coronary Artery Bypass Surgery
Authors: Zivkovic Igor , Krasic Stasa , Milacic Petar , Milicic Miroslav , Vukovic Petar , Tabakovic Zoran , Sagic Dragan , Ilijevski Nenad , Petrovic Ivana , Peric Miodrag , Bojic Milovan , Micovic Slobodan 
Published: February 2023

Abstract

Background
The optimal treatment strategy for patients with severe carotid artery disease undergoing coronary artery bypass grafting is still problematic. The important question is whether it is necessary to treat significant carotid disease in patients who have undergone coronary artery bypass grafting. This study analyzed short- and midterm results after same-day carotid artery stenting and coronary artery bypass grafting.

Methods
From 2013 to 2020, a total of 69 patients were enrolled in the study. Same-day carotid artery stenting and coronary artery bypass grafting were performed in all patients. The study's primary end points were the evaluation rate of stroke, myocardial infarction, and death within short- and midterm periods after the procedures.

Results
The 30-day mortality was 0%. The occurrences of perioperative adverse events, namely stroke, myocardial infarction, and transient ischemic attack, were 1 (1.4%), 1 (1.4%), and 4 (5.8%), respectively. Mean (IQR) follow-up time was 28 (IQR, 17–43) months. Six (8.8%) patients died during this period. Fatal stroke was registered in 2 cases, and 1 patient experienced a disabling stroke with a fatal outcome. The other 3 patients died because of chronic renal disease, a traffic accident, and for an unknown reason, respectively. Midterm survival in the group was 91.2%.

Conclusion
The study showed that same-day carotid artery stenting and coronary artery bypass grafting for concomitant carotid and coronary disease treatment could be a promising and feasible therapeutic strategy.
Aortic Dissection and COVID-19 Pneumonia in a Pregnant Woman at 34 Weeks of Gestation
Authors: Krzelj Kristina , Anic Darko 
Published: February 2023

Abstract
Between 0.1% and 0.3% of all aortic dissections occur during pregnancy. Arterial hypertension, connective tissue disorders, and congenital cardiovascular anomalies—including bicuspid aortic valves—are well-known risk factors. The causality between pregnancy and aortic dissection is unclear, but there have been some observations that COVID-19 illness may increase the risk. This report describes a pregnant woman at 34 weeks of gestation who had a bicuspid aortic valve and experienced an acute aortic dissection while ill with COVID-19 pneumonia. Computed tomography confirmed a type A aortic dissection and bilateral patchy pulmonary opacities. Cesarean delivery was performed, followed by replacement of the aortic valve with a mechanical aortic prosthesis and reconstruction of the ascending aorta and hemiarch. The intraoperative course was uneventful, and the patient was successfully weaned from mechanical ventilation after 51 hours. COVID-19 during pregnancy seems to increase the risk for aortic dissection, although there is no evidence base for an association. Because guidelines for diagnosis and treatment in such complex cases are lacking, care from a multidisciplinary team is crucial for successful outcomes.
Loading conditions impact on the compression fatigue behavior of filled styrene butadiene rubber
Authors: Yang Liu , Dai Xi , Zhao Xuan , Liu Feng , Xu Yunhui , Wang Yanqiu 
Published: February 2023

Abstract
Fatigue failure, commonly encountered in rubber materials, is a critical issue. In this study, the compression fatigue tests of filled styrene-butadiene rubber (SBR) under different loading conditions were performed, applying cylindrical specimens. A stress–strain curve and modulus drop curves were generated by nine fatigue loading cases, covering different R ratios in the range of 0 < R < 1. The temperature variation in the process of compression fatigue was explored. Three different approaches were applied to investigate the fatigue life of the SBR (it is used twice hence abbreviation should be used) vulcanizates. These methods were validated in assessing the fatigue failure of the specimens. According to the experimental fatigue life, a fatigue life prediction model based on strain amplitude as the damage parameter was established. The results demonstrated that both R ratio and strain amplitude could affect the fatigue life. For all the loading cases, the fatigue life generally increases with the increase of R ratio. Under the compression loading condition, the narrower range of strain and the lower mean strain are beneficial to the fatigue resistance of rubbers, which also indicates a larger pre-load provides much higher fatigue resistance. During the fatigue loading, the temperature rises rapidly until it reaches a peak value, then drops slightly, and finally reaches a plateau.
Transient thermal analysis of gas insulated switchgear modules using thermal network approach
Authors: Mudhigollam Uday Kumar , Tiwari Neelam , Rao Mandava Mohana 
Published: February 2023

AbstractThermal analysis of Gas Insulated Switchgear (GIS) modules is of utmost important to optimize their dimensions for higher current ratings. Temperature rise test simulation has to be carried out on GIS modules to ensure that the temperature rise of modules shall not exceed the allowable temperature limits. The analyses also help to estimate the time duration required for GIS modules to reach steady state temperature as per IEC 62271-102 and IEC 61869-2. In the present study, to conduct transient thermal analysis, a novel Thermal Network Model (TNM) has been proposed for gas insulated switchgear equipment of two important modules i.e., disconnector switch (DS) and current transformer (CT). GISmodules.m program is developed in the study to analyze effect of various parameters like type of material being used for HT conductor and enclosure, rated voltage, rated current and enclosure current on time varying behavior of temperature rise of conductor and enclosure. Finally, the temperature rise test has also been carried out on 245 kV and 420 kV GIS modules at rated current ranging from 3150 A to 4000 A. When the transient temperature measurements conducted on 420 kV DS and compared with the results obtained through proposed TNM based analyses, it is clear that temperatures are within difference of 3.3 °C for conductor and 1.2 °C for enclosure. Further, it is evident that the time taken for conductor and enclosure to reach steady state temperature is about 8–10 h depending on enclosure current magnitude and GIS configuration.
Exploring the state of research on motivation in second language learning: a review and a reliability generalization meta-analysis
Authors: Aryadoust Vahid , Soo Yu Xuan Natalie , Zhai Jiayu 
Published: February 2023

Abstract
We present a thematic review and analysis of the variables affecting language learning motivation (LLM) (2008–2022). The second-language motivational self-system (L2MSS) model was found to be the most applied construct in measuring LLM. Complex systems theory was also another method gaining prominence in LLM research to explain the interactions between micro- and macro-structures surrounding the learner in influencing motivation. Other factors such as socioeconomic status, dialogism and anagnorisis were also identified as variables relating to LLM. For instance, research on dialogism and dialogue has indicated the role of conversation in shaping identity, motivation, and meaning for learners. However, our review found that much of the focus in LLM research has been on the L2MSS learning or teaching experience, while daily living has been largely neglected. We further conducted a reliability generalization meta-analysis. Our analysis found an average reliability of 0.84 (CI = 0.816–0.856), with 34% of reliability coefficients falling below the lower bound of CI. A meta-regression analysis revealed that 16% of the variance in the reliability coefficients was predicted by the number of items in the instruments. Questionnaires with an internal consistency below the lower bound of 0.816 had an average of 4.14 items, while the rest had an average of 5.71 items. We further found significant publication bias. Based on our findings, we suggest areas for future research in LLM.