bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the July 2018 worldwide valsartan recall and shortage on global trends in antihypertensive medication use: a time-series analysis in 83 countries
Authors: Choi Yuna , Santhireswaran Araniy , Chu Cherry , Suda Katie J , Hernandez Inma , Magnani Jared W , Tadrous Mina 
Published: January 2023

ObjectivesThis study aims to examine the effects of the July 2018 worldwide valsartan recall and shortage on global trends of antihypertensive medication use in 83 countries.MethodsA time-series analysis of monthly purchases of valsartan, other angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) across 83 countries from January 2017 to July 2020 was conducted using the IQVIA MIDAS database. Trends in outcomes were investigated globally and by economic level (developed vs developing economies). The valsartan recall’s impact on antihypertensive use was assessed with interventional autoregressive integrated moving average modelling.ResultsGlobal valsartan utilisation trends decreased significantly by 15.7% (−61 166 515 SU; p<0.0001), while global purchases of other ARBs increased by 44.8% (+958 069 420 SU; p=0.8523) and ACEIs increased by 1.6% (+44 106 747 SU; p=0.1102). Of the 32 developed countries, 20 (62.5%) showed a decline in 1-month percentage change in valsartan purchases, whereas only 10 out of 33 developing countries (30.3%) experienced a decrease in valsartan purchases. Mean 1-month, 3-month and 6-month percentage changes for developed countries were −1.2%, −9.3% and −12.2%, respectively, while the changes for developing countries were 25.0%, 7.3% and −1.2%.ConclusionsGlobal valsartan purchases substantially decreased post-recall, highlighting the far-reaching impacts of drug shortages. Opposing utilisation trends by economic level raise concerns of potential distribution of contaminated medications from developed countries to developing countries. Concerted actions for equitable global access to quality medications and mitigation of drug shortages are needed.
Towards cost saving in surgery without compromising safety: stapleless laparoscopic splenectomy in a developing country—a prospective cohort study
Authors: Lasheen Omar , Yehia Mohamed , Salah Ayman , Mikhail Sameh , Hassan Ahmed 
Published: January 2023

BackgroundMinimally invasive surgery has been steadily growing in popularity. Control of splenic hilar vessels is the most delicate step during laparoscopic splenectomy (LS). In the earlier eras of LS, hilar vessels were controlled using clips and/or ligation. Laparoscopic staples were later introduced and have arguably led to an increase in popularity of LS. They do not abolish potential complications of splenectomy and theoretically represent an added operative cost.In this study, we aimed to assess the safety and efficacy of stapleless LS (using knots, haemostatic devices and clips) compared with the now more conventional stapled LS.MethodsA pilot randomised prospective study was conducted in a university hospital between September 2018 and April 2020. It included 40 patients randomly assigned to two equal groups: (1) 20 patients: stapleless LS and (2) 20 patients: LS using laparoscopic staples.We compared operative time, intra and postoperative complications and postoperative recovery.ResultsThere was no statistically significant difference between both groups across all comparative outcomes.ConclusionBoth techniques are comparable in terms of safety and operative time. In terms of cost efficiency, we recommend more comprehensive analyses of hospital costs.
JAG consensus statements for training and certification in flexible sigmoidoscopy
Authors: Siau Keith , Pelitari Stavroula , Green Susi , McKaig Brian , Rajendran Arun , Feeney Mark , Thoufeeq Mo , Anderson John , Ravindran Vathsan , Hagan Paul , Cripps Neil , Beales Ian L P , Church Karen , Church Nicholas I , Ratcliffe Elizabeth , Din Said , Pullan Rupert D , Powell Sharon , Regan Catherine , Ngu Wee Sing , Wood Eleanor , Mills Sarah , Hawkes Neil , Dunckley Paul , Iacucci Marietta , Thomas-Gibson Siwan , Wells Christopher , Murugananthan Aravinth 
Published: January 2023

IntroductionJoint Advisory Group (JAG) certification in endoscopy is awarded when trainees attain minimum competency standards for independent practice. A national evidence-based review was undertaken to update standards for training and certification in flexible sigmoidoscopy (FS).MethodsA modified Delphi process was conducted between 2019 and 2020 with multisociety representation from experts and trainees. Following literature review and Grading of Recommendations, Assessment, Development and Evaluations appraisal, recommendation statements on FS training and certification were formulated and subjected to anonymous voting to obtain consensus. Accepted statements were peer-reviewed by national stakeholders for incorporation into the JAG FS certification pathway.ResultsIn total, 41 recommendation statements were generated under the domains of: definition of competence (13), acquisition of competence (17), assessment of competence (7) and postcertification support (4). The consensus process led to revised criteria for colonoscopy certification, comprising: (A) achieving key performance indicators defined within British Society of Gastroenterology standards (ie, rectal retroversion >90%, polyp retrieval rate >90%, patient comfort <10% with moderate-severe discomfort); (B) minimum procedure count ≥175; (C) performing 15+ procedures over the preceding 3 months; (D) attendance of the JAG Basic Skills in Lower gastrointestinal Endoscopy course; (E) satisfying requirements for formative direct observation of procedural skill (DOPS) and direct observation of polypectomy skill (SMSA level 1); (F) evidence of reflective practice as documented on the JAG Endoscopy Training System reflection tool and (G) successful performance in summative DOPS.ConclusionThe UK standards for training and certification in FS have been updated to support training, uphold standards in FS and polypectomy, and provide support to the newly independent practitioner.
Localising culprit artery in inferior STEMI
Authors: Farhat-Sabet Ardalon , Smith Alexandra , Atwood John E , Pickett Christopher 
Published: January 2023

BackgroundST elevation myocardial infarction (STEMI) represents a cardiac emergency. Time to diagnosis, identification of culprit lesion, and intervention are important. Inferior STEMI represents a dilemma for cardiologists. The territory can be supplied by the right coronary artery (RCA) or the left circumflex coronary artery (LCx). Diagnostic algorithms have been proposed to predict the culprit artery.MethodsWe performed a single-centre retrospective cohort analysis of all patients admitted to our hospital from 2008 to 2020 with a diagnosis of inferior STEMI. We examined the diagnostic 12 lead ECG for quantification of ST elevation in leads II and III and compared this to culprit lesion found on angiography.ResultsThere were 304 patients identified with STEMI in our database; 105 were found to have an inferior myocardial infarction by ECG criteria. Ninety-nine were included in our study with either RCA or LCx culprit lesions on angiography (82 males, 17 females). The average age of these patients was 64.9 years old. Sensitivity, specificity, positive predictive value and negative predictive value for ST elevation in lead II exceeding lead III predicting LCx culprit lesion was 0.32 (95% CI 0.13 to 0.57), 0.94 (95% CI 0.86 to 0.98), 0.55 (95% CI 0.29 to 0.78), 0.85 (95% CI 0.81 to 0.89), respectively. Sensitivity, specificity, positive predictive value and negative predictive value for ST elevation in lead III exceeding lead II predicting RCA culprit lesion was 0.94 (95% CI 0.86 to 0.98), 0.32 (95% CI 0.13 to 0.57), 0.85 (95% CI 0.81 to 0.89), 0.55 (95% CI 0.29 to 0.78), respectively.ConclusionsIn inferior STEMI, comparison of ST elevation in leads II and III can reliably predict culprit lesion artery and guide intervention.Subject indexingCulprit artery localisation, inferior stemi, ECG.
Probing the $$h c\bar{c} $$ coupling at a Future Circular Collider in the electron-hadron mode
Authors: Hernández-Sánchez J. , Honorato C. G. , Moretti S. 
Published: January 2023

AbstractWe study the production of a neutral Higgs boson at a Future Circular Collider in the electron-hadron mode (FCC-eh) through the leading process$$e^- p \rightarrow \nu _e h q $$e-p→νehqassuming the decay channel$$h \rightarrow c \bar{c} $$h→cc¯, wherehis the Standard Model (SM)-like state discovered at the Large Hadron Collider (LHC). This process is studied in the context of a 2-Higgs Doublet Model Type III (2HDM-III) embedding a four-zero texture in the Yukawa matrices and a general Higgs potential, where both Higgs doublets are coupled with up- and down-type fermions. Flavour Changing Neutral Currents (FCNCs) are well controlled by this approach through the adoption of a suitable texture once flavour physics constraints are taken in account. Considering the parameter space where the signal is enhanced and in agreement with both experimental data and theoretical conditions, we analyse the aforementioned signal by taking into account the most important SM backgrounds, separatingc-jets from light-flavour and gluon ones as well asb-jets by means of efficient flavour tagging. We find that the$$h c \bar{c} $$hcc¯coupling strength can be accessed with good significance after a luminosity of 1 ab$$^{-1}$$-1for a 50 TeV proton beam and a 60 GeV electron one, the latter with a 80% (longitudinal) polarisation.
Constraints on primordial curvature spectrum from primordial black holes and scalar-induced gravitational waves
Authors: Yi Zhu , Fei Qin 
Published: January 2023

AbstractThe observational data of primordial black holes and scalar-induced gravitational waves can constrain the primordial curvature perturbation at small scales. We parameterize the primordial curvature perturbation by a broken power law form and find that it is consistent with many inflation models that can produce primordial black holes, such as nonminimal derivative coupling inflation, scalar–tensor inflation, Gauss–Bonnet inflation, and K/G inflation. The constraints from primordial black holes on the primordial curvature power spectrum with the broken power law form are obtained, where the fraction of primordial black holes in dark matter is calculated by the peak theory. Both the real-space top-hat and the Gaussian window functions are considered. The constraints on the amplitude of primordial curvature perturbation with Gaussian window function are around three times larger than those with real-space top-hat window function. The constraints on the primordial curvature perturbation from the NANOGrav 12.5 years data sets are displayed, where the NANOGrav signals are assumed as the scalar-induced gravitational waves, and only the first five frequency bins are used.
Dataset Search and Augmentation
Authors: Chen Zhiyu 
Published: January 2023

Data has become an indispensable part of our life. However, current mainstream commercial search engines do not support specialized functions for dataset search. A dataset usually consists of both metadata and data content. Existing information retrieval models designed for Web search cannot efficiently extract semantic information inside structured datasets, even when they contain textual content. Developing new algorithms for next-generation search engines to efficiently find datasets can benefit data practitioners in their data discovery experience.
In this dissertation, we consider how to effectively perform dataset search and augmentation. We start by providing an end-to-end description of a dataset search engine following the lifecycle of datasets. Our review includes web dataset acquisition techniques, dataset profiling and augmentation methods, and dataset search tasks and corresponding methods. In order to extract datasets from research articles, we present an information extraction framework to determine triples of interest which can be used for academic dataset search. We propose a feature-based method to augment tabular datasets with additional schema labels to help users and systems to better understand the datasets. We develop three methods for tabular dataset search: the first utilizes generated schema labels to enhance the search results; the second adopts pretrained language models to learn matching features; the third models the complex relations in the datasets as one or more graphs and uses graph neural networks to learn representations of queries and tables. To support dataset search in which a query is also a dataset, we propose universal dataset encoders which regard a dataset as a point set so that the encoded dataset representations can be used to search for similar datasets. Extensive experiments across multiple tasks demonstrate the superiority of our proposed methods over the state of the art.

Awarded by:
Lehigh University, Bethlehem, USA on 10 May 2022.

Supervised by:
Brian D. Davison.

Available at:
https://github.com/Zhiyu-Chen/Dissertation/blob/main/Dissertation_Dataset_Search.pdf.
Non-native freshwater fish from drainages of Rio Grande do Sul State, Brazil
Authors: Bertaco Vinicius de Araújo , Azevedo Marco Aurélio 
Published: January 2023

The present study catalogues exotic and allochthonous fish species found in the three main freshwater river drainages of Rio Grande do Sul State using records of scientific collections and literature, and discusses the main impacts caused by their introduction in natural environments. Ten exotic species are found in the area, i.e., Clarias gariepinus, Coptodon rendalli, Ctenopharyngodon idella, Cyprinus carpio, Hypophthalmichthys molitrix, Hypophthalmichthys nobilis, Ictalurus punctatus, Micropterus salmoides, Oncorhynchus mykiss and Oreochromis niloticus, belonging to five orders, nine genera and seven families. These fishes are native from African, Asian, European and North American countries. The eight allochthonous species, i.e., Acestrorhynchus pantaneiro, Hoplerythrinus unitaeniatus, Hoplias lacerdae, Megaleporinus macrocephalus, Piaractus mesopotamicus, Pachyurus bonariensis, Serrasalmus maculatus, and Trachelyopterus lucenai, belong to three orders, eight genera, and six families, are native from the Río La Plata basin, that includes the Río Uruguay, and have been all registered in the Laguna dos Patos. Two of these species are further recorded in the Rio Tramandaí system (A. pantaneiro and T. lucenai). The study also presentes a brief history of the first records of exotic species in the state and in the country, and their main vectors of introduction. According to the records of exotic species in scientific collections, the two exotic species with the highest number of records in the country are tilapias Coptodon rendalii (508 records) and Oreochromis niloticus (376 records), and most records occurred in the last two decades. The two carps Cyprinus carpio and Ctenopharyngodon idella are the only exotic species recorded in the three main drainage basins of the state. In addition, we warn about the importance of studies about the biology and negative impacts of exotic species over native species on the understanding of management in wild environments.
Crisis Response and Suicidal Behaviors of Essential Workers and Children of Essential Workers During the COVID-19 Pandemic
Authors: Sugg Margaret M. , Runkle Jennifer D. , Ryan Sophia C. , Singh Devyani , Green Shannon , Thompson Martie 
Published: January 2023

Objective: The COVID-19 pandemic has put unprecedented stress on essential workers and their children. Limited cross-sectional research has found increases in mental health conditions from workload, reduced income, and isolation among essential workers. Less research has been conducted on children of essential workers. We examined trends in the crisis response of essential workers and their children from April 2020 through August 2021. Methods: We investigated the impact during 3 periods of the pandemic on workers and their children using anonymized data from the Crisis Text Line on crisis help-seeking texts for thoughts of suicide or active suicidal ideation (desire, intent, capability, time frame), abuse (emotional, physical, sexual, unspecified), anxiety/stress, grief, depression, isolation, bullying, eating or body image, gender/sexual identity, self-harm, and substance use. We used generalized estimating equations to study the longitudinal change in crisis response across the later stages of the pandemic using adjusted odds ratios (aORs) for worker status and crisis outcomes. Results: Results demonstrated higher odds of crisis outcomes for thoughts of suicide (aOR = 1.06; 95% CI, 1.00-1.12) and suicide capability (aOR = 1.14; 95% CI, 1.02-1.27) among essential workers than among nonessential workers. Children of essential workers had higher odds of substance use than children of nonessential workers (aOR = 1.33; 95% CI, 1.08-1.65), particularly for Indigenous American children (aOR = 2.76; 95% CI, 1.35-5.36). Essential workers (aOR = 1.17; 95% CI, 1.07-1.27) and their children (aOR = 1.18; 95% CI, 1.07-1.30) had higher odds of grief than nonessential workers and their children. Conclusion: Essential workers and their children had elevated crisis outcomes. Immediate and low-cost psychologically supportive interventions are needed to mitigate the mental health impacts of the COVID-19 pandemic on these populations.
Co-medication with disulfiram markedly increased serum clozapine levels: Two case reports
Authors: Hahl-Häkkinen Lydia , Rask Susanna Maria , Solismaa Anssi , Ruuhonen Sanna , Leinonen Esa 
Published: January 2023

Background: Alcohol use disorder (AUD) is a significant co-morbidity in patients with schizophrenia. Clozapine offers some benefits in treating patients with refractory schizophrenia and AUD, but co-medicating with disulfiram is also common. Procedures: We report two cases where co-medicating with disulfiram led to a significant increase in clozapine serum levels. Findings: Clozapine serum levels decreased to one-third in Patient 1 when disulfiram was discontinued and started to increase again when disulfiram was reintroduced. Patient 2 developed toxic serum levels of clozapine during disulfiram treatment combined with heavy coffee drinking and symptoms reminiscent of neuroleptic malignant syndrome. Conclusions: Clozapine and disulfiram are both metabolized by cytochrome P450 CYP1A2 and clinically relevant interaction through this shared pathway is possible.
Appropriateness and complications of androgen deprivation therapy for prostate cancer: Can we do better? A retrospective observational analysis from a referral center
Authors: Oderda Marco , Bertetto Oscar , Barbera Giulia , Calleris Giorgio , Falcone Marco , Filippini Claudia , Marquis Alessandro , Marra Giancarlo , Montefusco Gabriele , Peretti Federica , Gontero Paolo 
Published: January 2023

Introduction: Androgen deprivation therapy (ADT) is the key of medical treatment for advanced prostate cancer (PCa), especially in elderly patients. However, the adherence of ADT prescription to current guidelines is not optimal and must be balanced against possible side effects. Aim of this study was to evaluate the prescriptive appropriateness of ADT and ADT-related adverse events in a referral center for PCa. Methods: Five hundred fifty six patients who received an outpatient prescription for ADT from 2014 to 2018 were retrospectively identified from an administrative database. Only standard ADT was considered, including GnRH agonists, GnRH antagonists, and antiandrogens. Prescriptive appropriateness was defined according to the last European Association of Urology (EAU) guidelines. Our cohort was stratified according to age categories and patient follow-up was updated. Results: Four hundred twenty five patients were available for analysis. Mean age was 80 years; 96.3% of our patients fell in the “elderly” category. There was a predominance of GnRH agonists over the antagonists (84.9% vs 13%). 15.5% of ADTs did not have an appropriate indication according to guidelines. Patient compliance to ADT was evaluated as good in 372 (87.5%) cases. ADT-related complications were detected in 166 (39%) patients: bone, cardiovascular, and other complications were reported in 7.3%, 8.9%, and 19% of patients. Progression of disease was noted in 165 (38.8%) cases during ADT. At last follow-up, 124 (30.1%) patients were deceased. Conclusions: In a referral center, most ADT prescriptions followed EAU guidelines, but a non-negligible proportion still did not fall within these indications, exposing patients to unnecessary side effects. Compliance to ADT was generally good with a predominant use of GnRH agonists. Tolerance to ADT was fair, even if standardized reports were lacking.
Seroconversion, seroreversion, and serowaffling among participants initiating antiretroviral therapy in Project DETECT
Authors: Stekler Joanne D , Violette Lauren R , Niemann Lisa A , McMahan Vanessa M , Katz David A , Chavez Pollyanna R , Clark Hollie A , Cornelius-Hudson Andy , McDougal Sarah J , Delaney Kevin P 
Published: January 2023

Background Incomplete HIV seroconversion and seroreversion are increasingly documented by testing and pre-exposure prophylaxis programs more than previously recognized. This analysis reports on incomplete seroconversion and seroreversion by specimen and test type among Project DETECT participants. Methods Project DETECT included a longitudinal study of point-of-care tests. Participants were categorized as having “incomplete seroconversion” if all timepoints had ≥1 nonreactive test at study censoring. Among participants with incomplete seroconversion, we defined “seroreversion” as sustained regression to nonreactive for any test following a reactive result. We define “serowaffling” as any reactive result followed by a nonreactive and then reactive result. We used Fisher’s exact tests to explore relationships between Fiebig stage at ART initiation and incomplete seroconversion, seroreversion, and serowaffling. Results Twenty of 1940 Project DETECT participants met criteria for this subset. Ten participants had complete seroconversion after a median of 23 (IQR 16–47) days following initial positive tests. Ten participants had incomplete seroconversion, eight of whom had seroreversion. Incomplete seroconversion with persistent nonreactive tests was seen only with oral fluid (OF). Of eight participants with seroreversion, all experienced seroreversion of OF tests if the test was ever reactive ( n = 6); seroreversion occurred in fingerstick and venipuncture tests in two participants. Serowaffling occurred in nine (45%) participants. No associations were seen between Fiebig stage at ART start and complete seroconversion, seroregression, or serowaffling in our sample. Conclusions OF tests may be particularly susceptible to providing false-negative results. Seroreversion and incomplete seroconversion among individuals on antiretroviral treatment may represent a growing problem for HIV testing and treatment programs.