bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two-branch multimodal fake news detection model based on multimodal bilinear pooling and attention mechanism
Authors: Guo Ying , Ge Hong , Li Jinhong 
Published: April 2023

IntroductionFake news spread in various areas has a major negative impact on social life. Meanwhile, fake news with text and visual content is more compelling than text-only content and quickly spreads across social media. Therefore, detecting fake news is a pressing task for the current society.MethodsConcern the problem of extracting insufficient features, and the inability to merge multi-modality features effectively in detecting fake news. In this article, we propose a method for detecting fake news by fusing text and visual data. Firstly, we use two-branch to learn hidden layer information of modality to obtain more helpful features. Then we proposed a multimodal bilinear pooling mechanism to better merge textual and visual features and an attention mechanism to capture multimodal internal relationships for the detection of fake news.Results and discussionThe experimental results demonstrated that our methodology outperformed the current state-of-the-art methodology on publicly accessible Weibo and Twitter datasets.
Application and discussion of the borehole radial deformation method in deep borehole geostress measurement
Authors: Han Zengqiang , Li Minghong , Wang Chao , Wang Jinchao , Huang Xiaohua 
Published: April 2023

Geostress is an important parameter in rock-related fields, such as civil engineering, mining engineering, and energy engineering. There are kinds of methods for geostress measurement; however, many methods still have some limitations, especially when facing deep vertical boreholes. In this paper, we studied the characteristics of borehole radial deformation under the action of geostress. First, the rule of borehole radial deformation under the action of a two-dimensional geostress was studied, and the shape of the borehole radial changes to an ellipse under the action of geostress was proved. We derived the relationship between the magnitude of principal stresses and the parameters of the borehole ellipse, revealing the rule that the principal axis direction of the borehole ellipse is the direction of principal stress, which is the theoretical basis for the geostress calculation method based on borehole radial deformation measurement. Furthermore, we developed an apparatus that can simultaneously measure the changes in borehole diameters in multi-directions. The apparatus was designed with a multi-contact equidistant arrangement, micro-optical imaging measurement, electronic compass azimuth measurement, etc. It can adapt to the complex testing environment of deep boreholes and realize real-time monitoring of the borehole deformation process. Indoor tests were carried out to verify the working performance of the apparatus. The results showed that the measuring accuracy of the apparatus can reach 6.987 μm, meeting the requirement of geostress measurement. Also, the results are well consistent with the loading force and direction of the testing machine. A field test was carried out in a deep borehole, and the borehole radial deformation data were obtained in the process of stress relief. The feasibility of the instrument and method was verified by comparison with the hydraulic fracturing method. This paper provides a new idea and method for geostress measurement, especially in deep vertical boreholes.
Soft-sediment deformation structures of mottled clay in Huizhou Quaternary basin, coastal South China
Authors: Chen Zhen , Wang Wen , Huang Ping , Tang Yongjie , Wang Jing , Zeng Qiang , Chen Cong 
Published: April 2023

Tectonically induced liquefaction and the resulting soft-sediment deformation structure (SSDS) can provide useful information on paleo-earthquakes, which is vital for the assessment of geohazard susceptibility in tectonically active regions. In this study, we combined sedimentary and chronological methods to the reveal detailed characteristics of the mottled clay in the Huizhou Quaternary Basin. The dating results suggest that mottled clay usually developed during the late Pleistocene, overlying the fluvial deposit or embedding homogeneous aeolian yellow silt. Mottled clay has a typical bimodal frequency distribution with modal sizes at 5 and 80–90 μm, which are identical to those of the yellow silt and the underlying fluvial sand, respectively. Micro-X-ray fluorescence mapping revealed high concentrations of Fe and Si in the red and white fraction, respectively. In addition, the red fraction of mottled clay has a high hematite content, similar to loess-like yellow silt, whereas the white fraction and the underlying fluvial sediments are dominated by goethite. This sedimentary evidence together suggests that the mottled clay could be an admixture of aeolian yellow silt and the underlying fluvial sand. Furthermore, diverse deformed structures (e.g., fragmented structures, sand veins, sand dykes and flame structures) were observed in mottled clay. Therefore, we suggest that the mottled clay structure in the Huizhou Basin is a product of liquefaction-induced SSDS. Tectonic activity was considered to have triggered the liquefaction and SSDS, which is supported by the close spatial relationship between the mottled clay and regional faults. We propose that the SSDS of mottled clay could be a potential indicator of paleo-earthquakes in the coastal Quaternary basins of the northern South China Sea.
Changes in drought characteristics over China during 1961–2019
Authors: Wen Qixin , Chen Huopo 
Published: April 2023

Drought is extremely complex and can be influenced by various factors. This study uses Penman-Monteith (PM) method to calculate the potential evapotranspiration and get the monthly drought metric of Standardized Precipitation-Evapotranspiration Index (SPEI) across China during the period of 1961–2019. Results show that the regions of the west of Northwest China (WNWC), Northeast China (NEC), and South China (SC) are reported to experience a wetting trend, while the droughts in the regions of the east of Northwest China (ENWC), North China (NC), and Southwest China (SWC) deteriorated over the past decades. Seasonally, the significant wetting trends mainly occurred in summer, autumn, and winter for WNWC, while mainly in winter for the region of NEC. Additionally, the droughts in China show an obvious interdecadal variability, with more severe droughts for the periods of 1961–1979 and 2000–2019, but with relatively fewer events in the period of 1980–1999. During the 1960 s and 1970 s, droughts in China are observed to mainly happen in summer and winter, while the droughts mainly occurred in autumn and winter during the 1980 s and 1990 s. Since the early 21st century, both the frequency and intensity of spring droughts have increased obviously and played a dominant role in seasonal droughts. Further studies indicate that the drought changes in southern China are mainly affected by the precipitation anomalies, while that in northern China are mainly influenced by the temperature and wind speed anomalies. Hence, our analyses provide theoretical basis for further understanding the drought changes and the prevention control of drought disasters in China.
Facilitating epistemic fluency of undergraduate students during the interdisciplinary research process
Authors: van Lambalgen Rianne M. , de Vos Febe 
Published: April 2023

IntroductionIn this article we show how students share knowledge when integrating disciplinary insights in an interdisciplinary research project. More specifically, this research looks at how students communicate to create a shared mental model during moderated sessions with use of CoNavigator as an interdisciplinary collaboration tool or Miro as an online mind map tool. The study focuses on the interdisciplinary capstone of the Liberal Arts and Sciences bachelor program at Utrecht University (LAS), where students collaborate in multidisciplinary groups by going through the interdisciplinary research process (IRP).This process asks students to define an interdisciplinary research question, to define disciplinary insights and combine each other’s disciplinary insights to create a more comprehensive understanding of their research question. The integration of disciplinary insights requires working with different perspectives and acknowledging uncertainty, thereby requiring epistemic fluency and higher modes of knowledge. This research looks at how a structured session with CoNavigator or Miro can help students use these processes when integrating insights.MethodsSeven groups participated in this research, with whom we moderated a session using either CoNavigator or Miro at the start of the integration phase with the purpose of sharing disciplinary insights and finding common ground. We observed each group, looking at communication related to construction, constructive conflict and co-construction. In addition, we looked at evaluation of the tool immediately after the session and the assessment of the integration chapter of all groups.ResultsWe found that each phase of the moderated session elicited different responses in terms of constructive conflict and co-construction, thereby helping students to actively work with different ways of knowing and to define and connect disciplinary differences. In their communication, students show examples of epistemic fluency and higher modes of knowledge, although this did not directly translate into a better assessment of their integration chapter.DiscussionThese results show that discussing disciplinary differences and finding common ground through a session with CoNavigator or Miro gives students a structured way to start with their interdisciplinary integration. We argue that LAS-students exhibit epistemic fluency when working with the tools, but also develop this throughout the session. It appears that the epistemic fluency students already possess prior to the IRP can be further developed by the epistemic fluency expressed by teammates during the tool session. The practice and development of epistemic fluency will always involve uncertainties, but facilitating interdisciplinary integration in this way is valuable as it provides an opportunity to work with these uncertainties and offer students space to speak and integrate freely.
Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma
Authors: Zhao Lu , Gao Jiali , Chen Gongqi , Huang Chunli , Kong Weiqiang , Feng Yuchen , Zhen Guohua 
Published: April 2023

Background: Type 2 (T2)-low asthma can be severe and corticosteroid-resistant. Airway epithelial cells play a pivotal role in the development of asthma, and mitochondria dysfunction is involved in the pathogenesis of asthma. However, the role of epithelial mitochondria dysfunction in T2-low asthma remains unknown.Methods: Differentially expressed genes (DEGs) were identified using gene expression omnibus (GEO) dataset GSE4302, which is originated from airway epithelial brushings from T2-high (n = 22) and T2-low asthma patients (n = 20). Gene set enrichment analysis (GSEA) was implemented to analyze the potential biological pathway involved between T2-low and T2-high asthma. T2-low asthma related genes were identified using weighted gene co-expression network analysis (WGCNA). The mitochondria-related genes (Mito-RGs) were referred to the Molecular Signatures Database (MSigDB). T2-low asthma related mitochondria (T2-low-Mito) DEGs were obtained by intersecting the DEGs, T2-low asthma related genes, and Mito-RGs. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed to further explore the potential function of the T2-low-Mito DEGs. In addition, the hub genes were further identified by protein-protein interaction (PPI), and the expressions of hub genes were verified in another GEO dataset GSE67472 and bronchial brushings from patients recruited at Tongji Hospital.Results: Six hundred and ninety-two DEGs, including 107 downregulated genes and 585 upregulated genes were identified in airway epithelial brushings from T2-high and T2-low asthma patients included in GSE4302 dataset. GSEA showed that mitochondrial ATP synthesis coupled electron transport is involved in T2-low asthma. Nine hundred and four T2-low asthma related genes were identified using WGCNA. Twenty-two T2-low-Mito DEGs were obtained by intersecting the DEGs, T2-low asthma and Mito-RGs. The GO enrichment analysis of the T2-low-Mito DEGs showed significant enrichment of mitochondrial respiratory chain complex assembly, and respiratory electron transport chain. PPI network was constructed using 22 T2-low-Mito DEGs, and five hub genes, ATP5G1, UQCR10, NDUFA3, TIMM10, and NDUFAB1, were identified. Moreover, the expression of these hub genes was validated in another GEO dataset, and our cohort of asthma patients.Conclusion: This study suggests that mitochondria dysfunction contributes to T2-low asthma.
A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors
Authors: Davis-Gardner Meredith E. , Weber Jesse A. , Xie Jun , Pekrun Katja , Alexander Eric A. , Weisgrau Kim L. , Furlott Jessica R. , Rakasz Eva G. , Kay Mark A. , Gao Guangping , Farzan Michael , Gardner Matthew R. 
Published: April 2023

IntroductionUse of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular administration resulted in poor expression with anti-drug antibodies (ADA) responses against the bNAb.MethodsHere we compared the expression of, and ADA responses against, an anti-SIV antibody ITS01 when delivered by five different AAV capsids. We first evaluated ITS01 expression from AAV vectors three different 2A peptides. Rhesus macaques were selected for the study based on preexisiting neutralizing antibodies by evaluating serum samples in a neutralization assay against the five capsids used in the study. Macaques were intramuscularly administered AAV vectors at a 2.5x10^12 vg/kg over eight administration sites. ITS01 concentrations and anti-drug antibodies (ADA) were measured by ELISA and a neutralization assay was conducted to confirm ex vivo antibody potency.ResultsWe observed that ITS01 expressed three-fold more efficiently in mice from AAV vectors in which heavy and light-chain genes were separated by a P2A ribosomal skipping peptide, compared with those bearing F2A or T2A peptides. We then measured the preexisting neutralizing antibody responses against three traditional AAV capsids in 360 rhesus macaques and observed that 8%, 16%, and 42% were seronegative for AAV1, AAV8, and AAV9, respectively. Finally, we compared ITS01 expression in seronegative macaques intramuscularly transduced with AAV1, AAV8, or AAV9, or with the synthetic capsids AAV-NP22 or AAV-KP1. We observed at 30 weeks after administration that AAV9- and AAV1-delivered vectors expressed the highest concentrations of ITS01 (224 µg/mL, n=5, and 216 µg/mL, n=3, respectively). The remaining groups expressed an average of 35-73 µg/mL. Notably, ADA responses against ITS01 were observed in six of the 19 animals. Lastly, we demonstrated that the expressed ITS01 retained its neutralizing activity with nearly the same potency of purified recombinant protein.DiscussionOverall, these data suggest that the AAV9 capsid is a suitable choice for intramuscular expression of antibodies in nonhuman primates.
Comparative genomic analyses of the clinically-derived Winkia strain NY0527: the reassignment of W. neuii subsp. neuii and W. neuii subsp. antitratus into two separate species and insights into their virulence characteristics
Authors: Cai Xunchao , Peng Yao , Li Meng , Qiu Yifeng , Wang Yuhan , Xu Long , Hou Qi 
Published: April 2023

BackgroundWinkia neuii, previously known as Actinomyces neuii, is increasingly recognized as a causative agent of various human infections, while its taxonomy and genomic insights are still understudied.MethodsA Winkia strain NY0527 was isolated from the hip abscess of a patient, and its antibiotic susceptibility was assessed. The genome was hybrid assembled from long-reads and short-reads sequencing. Whole-genome-based analyses on taxa assignment, strain diversity, and pathogenesis were conducted.ResultsThe strain was found to be highly susceptible to beta-lactam antibiotics, but resistant to erythromycin, clindamycin, and amikacin. The complete genome sequences of this strain were assembled and found to consist of a circular chromosome and a circular plasmid. Sequence alignment to the NCBI-nt database revealed that the plasmid had high sequence identity (&gt;90%) to four Corynebacterium plasmids, with 40–50% query sequence coverage. Furthermore, the plasmid was discovered to possibly originate from the sequence recombination events of two Corynebacterium plasmid families. Phylogenomic tree and genomic average nucleotide identity analyses indicated that many Winkia sp. strains were still erroneously assigned as Actinomyces sp. strains, and the documented subspecies within W. neuii should be reclassified as two separate species (i.e., W. neuii and W. anitratus). The core genome of each species carried a chromosome-coded beta-lactamase expression repressor gene, which may account for their broadly observed susceptibility to beta-lactam antibiotics in clinical settings. Additionally, an ermX gene that expresses fluoroquinolone resistance was shared by some W. neuii and W. anitratus strains, possibly acquired by IS6 transposase-directed gene transfer events. In contrast, tetracycline resistance genes were exclusively carried by W. neuii strains. In particular, W. neuii was found to be more pathogenic than W. anitratus by encoding more virulence factors (i.e., 35–38 in W. neuii vs 27–31 in W. anitratus). Moreover, both species encoded two core pathogenic virulence factors, namely hemolysin and sialidase, which may facilitate their infections by expressing poreformation, adhesion, and immunoglobulin deglycosylation activities.ConclusionThis study highlights the underappreciated taxonomic diversity of Winkia spp. and provides populational genomic insights into their antibiotic susceptibility and pathogenesis for the first time, which could be helpful in the clinical diagnosis and treatment of Winkia spp. infections.
Minimally invasive treatment for glioblastoma through endoscopic surgery including tumor embolization when necessary: a technical note
Authors: Sakata Tomohiro , Tanikawa Motoki , Yamada Hiroshi , Fujinami Ryota , Nishikawa Yusuke , Yamada Shigeki , Mase Mitsuhito 
Published: April 2023

BackgroundAlthough there have been some reports on endoscopic glioblastoma surgery, the indication has been limited to deep-seated lesions, and the difficulty of hemostasis has been a concern. In that light, we attempted to establish an endoscopic procedure for excision of glioblastoma which could be applied even to hypervascular or superficial lesions, in combination with pre-operative endovascular tumor embolization.MethodsMedical records of six consecutive glioblastoma patients who received exclusive endoscopic removal between September and November 2020 were analyzed. Preoperative tumor embolization was performed in cases with marked tumor stain and proper feeder arteries having an abnormal shape, for instance, tortuous or dilated, without passing through branches to the normal brain. Endoscopic tumor removal through a key-hole craniotomy was performed by using an inside-out excision for a deep-seated lesion, with the addition of an outside-in extirpation for a shallow portion when needed.ResultsEndoscopic removal was successfully performed in all six cases. Before resection, endovascular tumor embolization was performed in four cases with no resulting complications, including ischemia or brain swelling. Gross total resection was achieved in three cases, and near total resection in the other three cases. Intraoperative blood loss exceeded 1,000 ml in only one case, whose tumor showed a prominent tumor stain but no proper feeder artery for embolization. In all patients, a smooth transition to adjuvant therapy was possible with no surgical site infection.ConclusionEndoscopic removal for glioblastoma was considered to be a promising procedure with minimal invasiveness and a favorable impact on prognosis.
Effects of ABVD chemotherapy on ovarian function: epidemiology, hormonal dosages and ultrasound morphologic analyses in 270 patients with Hodgkin’s disease
Authors: Ciccarone Mariavita , Cavaceppi Paola , Tesei Cristiano , Brunetti Stefania , Pulsoni Alessandro , Annibali Ombretta , Gasparoli Cristiano , Battistini Roberta , Hohaus Stefan , Pelliccia Sabrina , Tafuri Agostino , Cox Maria Christina , Cantonetti Maria , Rigacci Luigi , Abruzzese Elisabetta 
Published: April 2023

IntroductionClassical Hodgkin Lymphoma (HL) is a lymphoproliferative disease typically diagnosed in the young. The excellent results obtained with current treatment lead to long survival with age-related complications affecting patients’ survival and quality of life. One issue affecting HL patients is infertility. This problem can be easily overcome in males with seminal liquid cryopreservation, however, in females it is more complex either in terms of the quality of the cryopreserved material or the patients’ age at diagnosis. Moreover, not all chemo- or radio-therapies have the same negative impact on fertility.The main objectives of this study was to collect epidemiological information on HL patients involved in fertility preservation counseling and to analyze the impact of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine), the standard treatment for HL, on ovarian function, hormonal levels and ovarian and uterine tissue morphologies. Patterns of fertility preservation were also reported.MethodsData were obtained from 270 female patients at HL onset who were interested in fertility counseling prior to therapy initiation. Each patient was assessed at HL diagnosis for levels of Anti-Mullerian Hormone (AMH), Follicle Stimulating Hormone (FSH), and 17β-oestradiol (17β-oe), with additional assessments at 6 and 12 months after chemotherapy. Patients were evaluated with ultrasound scans to study the number of ovarian follicles and the degree of uterine thickness at the same timepoints.ResultsThe average patient AMH level showed a statistically significant reduction at 6 months after chemotherapy (p=0.05) and by the 12 month time point returned to near pre-chemotherapy values. FSH and 17β-oe levels did not significantly vary throughout the study period. ABVD chemotherapy was associated with a significant reduction of both ovarian follicles and endometrial thickness at the 6 month time point followed by a recovery at the 12 time point in both ovaries. Different results were observed when patients changed treatment to a more intensive one.DiscussionBased on the results from the hormonal measurements and the follicle echography, it appears that the toxic effect of ABVD on fertility is transient, whereas, in contrast, more intensive therapies may potentially be more harmful and long-lasting.