bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of knowledge and competencies regarding sex, gender and further diversity aspects into the curricula of health professions education in Germany – barriers and supporting factors
Authors: Ludwig Sabine , Dettmer Susanne , Kohl Raphael , Kühn Kristin , Kaczmarczyk Gabriele , Seeland Ute 
Published: May 2023

Abstract
Background
Knowledge of sex, gender and further diversity categories is important to achieve equitable and individualized healthcare. An official statement of the German government stipulates the mandatory integration of sex and gender aspects into the curricula of health professions. Here we aim at evaluating the extent of curricular integration as well as barriers and factors supporting the integration.
Methods
The study was conducted online between January and March 2020. Three semi-standardized questionnaires were developed and sent to the deans of all medical faculties and a random sample of 197 (36.7%) heads of nursing schools (NS) and 97 (33.9%) heads of physiotherapy schools (PS). They were asked about the extent of curricular integration of diversity aspects as well as barriers and aspects facilitating the integration.
Results
The response rate was 75.6% (n=31; MS), 52.5% (n=94; NS) and 54.6% (n=53; PS). The highest level of curricular integration was achieved by 3.7% (MS), 4.8% (NS) and 6.4% (PS). Teachers were indicated to be mainly responsible for the integration (MS: 36%; NS: 73%; PS: 65%). Sociocultural aspects were integrated to a lesser extent in MS curricula compared to NS and PS. Qualitative analysis showed lack of gender theory in curricula.
Conclusions
Sex and gender aspects are integrated into around 30% of medical, nursing and physiotherapy curricula. Main supporting factors were the integration into the German National Learning Catalogue of Medicine and framework curricula. Case discussions were considered to be the most suitable teaching format. Future directions are the integration of gender theories.
Hooded Vulture Necrosyrtes monachus is at risk of extinction in Benin: a result of its poaching for belief-based use and decreasing food availability
Authors: DABONÉ Clément , ADJAKPA Jacques Boco , DANSI Mathias Fanou , THOMPSON Lindy J. , DISSOU Florent Essin , WEESIE Peter D. M. 
Published: May 2023

Abstract
In recent years, the situation of Hooded Vulture Necrosyrtes monachus in West Africa has gone sour. However, in some restricted area in this region the species is still found in relative abundance. To find out more about the situation in West Africa, we set out to assess and ascertain the status of the Hooded Vulture in Northern Benin. We conducted road counts, on paved and unpaved roads and along small trails over a total length of 1451 km linking a total of 33 towns and townships. While the road counts were being conducted, we also explored and examined potential threats in Hooded Vultures based on interviews conducted with local abattoir watchmen, veterinarians, butchers and foresters. A total of 52 Hooded Vultures were counted mostly in the departments of Atacora (32) but also in Alibori (10) and Borgou (10). The relative abundance was four Hooded Vultures per 100 km, highlighting the near extirpation of this bird from Benin. A total of 49 interviews revealed that poaching for belief-based use (through shooting, and traps) and decreasing food availability remain the most important threats for Hooded Vultures in Northern Benin. If these threats are not mitigated, we predict the extirpation of the Hooded Vulture in the years ahead in Benin. Conservation measures including awareness campaigns, and the improvement and enforcement of legislation to guarantee the protection of Hooded Vultures, must be urgently implemented for their conservation.
Life has become more colourful: the social and economic outcomes of community-led sanitation initiatives in the rural Philippines
Authors: Sorcher Rachael , Cloete Elene , Salazar Ami Dasig , Gatchalian Elvis , Gonzales Juanjoe 
Published: May 2023

AbstractThis article considers the impact of improved sanitation beyond physical well-being. Based on the experiences of women from three community-based organisations (CBOs) in the rural Philippines, this article expands on documented non-health related outcomes of health, safety and security, cleaner surroundings, and ownership, to also include those linked to household income, livelihood, and CBOs. Drawing from the participatory and qualitative methods of Photovoice and Most Significant Change, semi-structured interviews and individual photo conversations were conducted among 13 CBO leaders and 50 sanitation project participants, respectively. Findings suggest that CBOs enable improved sanitation, and such improvements include a personal and communal change in the form of reformed sanitation and hygiene practices, enhanced independence, privacy, and security, and improved ability to reclaim spaces for personal and public use, cultivation, and economic stimulation. Findings also underscore the idea that people may be more likely to adopt and sustain improved sanitation efforts if they are made aware of the additional non-physical health advantages of doing so.
Precipitation trend identification with a modified innovative trend analysis technique over Lake Issyk-Kul, Kyrgyzstan
Authors: Alifujiang Yilinuer , Abuduwaili Jilili , Abliz Abdugheni 
Published: May 2023

Abstract
The main concern of this study is using a new type of innovative trend analysis (ITA) method with a particular graphical illustration. It compares the results with the classic MK trend test at a 95% confidence level. Among the 15 annual and seasonal data series (3 weather stations annually, spring, summer, autumn, and winter) studied, the MK trend test found significant increasing trends of 3 data series (20%). However, using the new ITA method, 6 data series (40%) ‘high’ and ‘low’ simultaneously showed a significant increasing trend. The new ITA method can also detect all significant trends identified by the MK trend test. As for the new ITA method, the ‘high’ values of the 12 data series (80%) exhibited significant increasing patterns, and the 9 data series (60%) displayed significant increasing patterns for ‘low’ values. According to the ‘low’ and ‘high’ values, a gain one data series (6.7%) manifested significant decreasing trends. These results detailed annual and seasonal precipitation data series patterns by evaluating ‘low’ and ‘high’ values. The findings also demonstrated that the new method runs counter to the previous ITA.
Osimertinib-induced Keratitis and Secondary Toxic Epidermal Necrotic
Drug Eruption- A Case Report and Literature Review
Authors: Xu Yunhua , Li Yong , Luo Jie , Tang Rong 
Published: May 2023

Background:
Osimertinib is a third-generation Tyrosine Kinase inhibitor, mainly used
in non-small cell lung cancer with EGFR mutation. Its efficacy and safety have been confirmed by
clinical practice. Toxic epidermolysis necrotizing disease (TEN) is a severe drug eruption that is
rare in clinics and has a high mortality rate. Toxic epidermal necrotic drug rash caused by
Osimeritinib is even rarer.

Objective:
investigate the rare side effects of Osimertinib through a case of toxic Epidermal
necrosis.

Case Presentation:
A 63-year-old female patient was diagnosed with lung adenocarcinoma with
brain metastases, and genetic testing revealed an EGFR21 exon mutation. The disease progressed
24 days after the administration of gefitinib, then the patient switched to Osimertinib (80 mg QD)
and, resulting in keratitis and secondary systemic toxic epidermolysis necrotizing disease (TEN).
Finally, the patient died.

Conclusion:
Although the clinical use of osimertinib is becoming widespread, the side effects may
not be fully understood. Clinicians should pay more attention to the occurrence of the side reaction
and deal with it in time.
E7386 is not a Specific CBP/β-Catenin Antagonist
Authors: Kahn Michael , Higuchi Yusuke , Nguyen Cu , Chimge Nyam-Osor , Ouyang Ching , Teo Jia-Ling 
Published: May 2023

Background and Objective:
The first clinically evaluated CBP/β-catenin antagonist, PRI-724, displayed an excellent safety profile administered intravenously via continuous infusion. Eisai recently disclosed a third-generation, orally available, reportedly CBP/β-catenin antagonist, E7386. However, several structural features and the reported cytotoxicity of E7386 were unexpected for a specific CBP/β-catenin antagonist. Therefore, we undertook a comparison of E7386 versus the highly specific bona fide CBP/β-catenin antagonists, ICG-001 and C82, the active agents derived from the prodrug PRI-724.

Introduction:
CBP/β-catenin antagonists rebalance the equilibrium between CBP/β-catenin and p300/β-catenin dependent transcription and may be able to treat or prevent many diseases of aging via maintenance of somatic stem cell pool and regulating mitochondrial function and metabolism involved in differentiation and immune cell function. The safety, efficacy, and therapeutic potential of the specific CBP/β-catenin antagonists, ICG-001, and the second-generation compound, C82, the active agent derived from the pro-drug PRI-724, have been studied extensively in a variety of preclinical disease models and in the clinic for oncology and hepatic fibrosis. However, the lack of oral bioavailability has hampered the further development of PRI-724. Thus, Eisai recently proposed a third-generation, orally available, reportedly CBP/β-catenin antagonist E7386. Here, we have performed a comparative analysis of E7386 with the highly specific bona fide CBP/β-catenin antagonists, ICG-001 and C82.

Methods:
We utilized a series of previously validated biochemical and transcriptional assays to investigate the selective targeting of the CBP/β-catenin interaction in conjunction with global transcriptional profiling to compare the three small molecules, ICG-001, C82, and E7386.

Results:
Our data cast significant doubt that the mechanism of action of E7386 is via specific CBP/β-catenin antagonism.

Conclusion:
It can thus be concluded that E7386 is not a specific CBP/β-catenin antagonist.
Advancement of Nanocarriers-based Therapeutics for Effective Management of
Colorectal Cancer
Authors: Ashique Sumel , Garg Ashish , Kumar Prashant , Mishra Neeraj , Hussain Afzal , Upadhyay Aakash , Kumar Shubneesh , Farid Arshad 
Published: May 2023

Background:
Colorectal cancer is still challenging for scientists and healthcare professionals. Conventional treatment methods are associated with various limitations in clinical bed and patient compliance. However, novel nanocarrier-based approaches have opened a new window for improved therapy and a new future perspective.

Introduction:
Cancer is the deadliest disease globally and is challenging to healthcare systems. Colorectal cancer (CRC) is the third most common cancer in the world, affecting all age groups and is the most common cancer in 23 countries, as per the World Health Organization (WHO).

Methods:
In this review, we addressed the nanocarrier-based strategic treatment of colorectal cancer, along with major findings, limitations, and future perspectives. For this, we thoroughly reviewed several literatures downloaded from prime sources, such as google scholar, Web of Science, PubMed, and Publon. To filter the exact data needed, we used keywords alone or in combination. Various relevant articles were obtained from the reference section of the selected papers.

Result and Discussion:
It is necessary to have an effective and targeted treatment option to control CRC other than available remedies. Nanotechnology has been widely used to diagnose and treat several cancer types. Advances in nanomedicine and phytonanomedicine have promoted novel identification methods to treat colorectal cancer patients. There are several nanocarriers recommended for clinical purposes. However, to date, only a few clinically approved nanocarriers can load anticancer moieties and selectively bind to cancer cells. Some nanocarriers transport and release treatments to the target colorectal area but provide few benefits.

Conclusion:
In this review, various nanoparticles (NPs) with unique properties have been discussed in relation to managing colorectal cancer, along with major outcomes of clinical trials and successful patents published so far.
Pengaruh Pola Asuh Permisif Terhadap Pelaku Tawuran Pelajar SMA di Sukabumi
Authors: Resti Neng , Sardin Sardin , Utami Nindia Fajria 
Published: May 2023

Tugas seorang pelajar adalah belajar dan juga menuntut ilmu, Ada kalanya pelajar dengan rentang usia 16-18 tahun menunjukan perkembangan nya ke arah negatif yaitu aksi tawuran. Dari permasalahan tersebut penulis melakukan penelitian yaitu : pengaruh pola asuh permisif terhadap pelaku tawuran pelajar di SMK sukabumi, Dengan tujuan mengetahui seberapa besar pengaruh pola asuh permisif terhadap pelaku tawuran pelajar di SMK sukabumi. penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik pengumpulan data berupa kuesioner dengan responden sejumlah 39 orang. Hasil penelitian ini didapat hasil 68,4% pengaruh pola asuh permisif menjadi penyebab terjadinya aksi tawuran pelajar di smk sukabumi.
Associations between Net Gastrointestinal Alkali Absorption, 24-Hour Urine Lithogenic Factors, and Kidney Stones
Authors: Ferraro Pietro Manuel , Taylor Eric N. , Asplin John R. , Curhan Gary C. 
Published: May 2023

Background
It is not clear whether kidney stone formers have an abnormal handling of alkali and acid precursors in the gut, which might affect urine composition and ultimately stone formation. In this study, we aimed to investigate the determinants of net gastrointestinal alkali absorption and its associations with key urinary parameters in a large group of stone formers and non–stone formers.

Methods
Data were collected from three independent cohorts with at least one 24-hour urine collection. We explored potential determinants of net gastrointestinal alkali absorption and the association between net gastrointestinal alkali absorption, urinary parameters, and stone former status. Finally, we estimated the proportion of the association between urine parameters and stone former status explained by differences in net gastrointestinal alkali absorption.

Results
The analysis included 6067 participants (1102 men and 4965 women; 698 and 1804 of whom were stone formers, respectively). Average net gastrointestinal alkali absorption values were consistently lower in stone formers across the three cohorts (from −15.0 to −4.9 mEq/d). Age was directly associated with net gastrointestinal alkali absorption, whereas body mass index and net endogenous acid production were inversely associated. Net gastrointestinal alkali absorption was inversely associated with supersaturation for calcium oxalate, uric acid, and renal net acid excretion and directly associated with supersaturation for calcium phosphate, urine pH, and citrate. The odds of being a stone former was 15% (13%–17%) lower per 10 mEq/24 hours higher net gastrointestinal alkali absorption. Differences in net gastrointestinal alkali absorption explained a modest amount of the differences between stone formers and non–stone formers for supersaturation for calcium oxalate (6.3%) and a sizable amount for supersaturation for uric acid (15.2%), urine pH (38.3%), citrate (26.2%), and renal net acid excretion (63.4%).

Conclusions
Kidney stone formers have lower net gastrointestinal alkali absorption, and this explains differences in urine composition and the likelihood of stone formation.
Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers
Authors: LaFavers Kaice A. , Gaddy Anna R. , Micanovic Radmila , Lingeman James , Williams James C. , Coe Fredric L. , El-Achkar Tarek M. , Worcester Elaine 
Published: May 2023

Background
Uromodulin is a protein made only by the kidney and released in urine, circulating in polymerizing and nonpolymerizing forms. This protein's multiple functions include inhibition of stone formation in the urine. The physiological determinants of uromodulin production are incompletely understood.

Methods
We investigated changes in uromodulin levels and key factors governing its production and release in urine and serum. We performed an experiment to determine whether water loading, a common intervention to prevent stone formation, will alter the rate of uromodulin production. During a 2-day period, 17 stone forming participants and 14 control participants were subjected to water loading (day 1) and normal fluid intake (day 2). Uromodulin levels were measured on timed hourly collections in urine and plasma during the period of the study.

Results
Water loading increased urinary uromodulin secretion (33±4 versus 10±4 μg/min at baseline, P < 0.0001) in stone formers and control participants. Despite high urine volumes, most participants maintained relatively stable urinary uromodulin concentrations. Native Western blots for polymerizing and nonpolymerizing uromodulin suggest that polymerizing uromodulin was the predominant form at higher urinary flow volumes. Urine flow rates and sodium excretion were significant correlates of urinary uromodulin production. Water loading did not affect serum uromodulin levels, which were also not associated with urinary uromodulin.

Conclusions
Water loading increases the secretion of polymerizing urinary uromodulin. This increased secretion reduces the variability of urinary uromodulin concentrations despite high urine volumes. Serum uromodulin levels were not affected by this treatment.
Rip Van Winkle: el héroe improductivo
Authors: Garduño Moreno Juan Gabriel , Gómez-Pezuela Reyes María del Carmen 
Published: May 2023

A doscientos años de la publicación de la obra de Washington Irving, Rip Van Winkle (1820), la caracterización del protagonista que más ha prevalecido es la de un individuo perezoso, despreocupado e improductivo. A lo largo de la obra, el personaje es retratado como alguien que muestra poco interés en ocuparse en algún trabajo que le proporcione beneficios económicos. Presionado por las expectativas de la sociedad que lo conminan a conducirse como un “buen marido”, Van Winkle elude sus obligaciones domésticas y opta por vagabundear en una montaña cercana. En este artículo se propone una lectura del relato a la luz de algunas claves del pensamiento del filósofo Byung-Chul Han, concretamente las concernientes al concepto de vita contemplativa, cuya exposición se desglosa en El aroma del tiempo (2015) y La sociedad del cansancio (2017). El análisis ilumina una faceta distinta del personaje y lo muestra como un hombre sensible, inclinado a adentrarse en un estado contemplativo. Se concluye que la actitud de Van Winkle hacia la vida expresa un rechazo ante la inevitable llegada del progreso y simboliza la inefable permanencia de un mundo que se resiste a cambiar ante la inminente urbanización provocada por la industrialización. En tal sentido, su conducta representa una dura crítica hacia el imperativo de la productividad dentro del contexto de la sociedad norteamericana de principios del siglo diecinueve.
Service Quality Assessment of Retail Pharmacies in Balingasag, Misamis Oriental Based on Hybrid AHP-RSQ Model
Authors: Salvaña Bernard C. , Saludes Zaira Loren R. , Lumacad Gernel S. , Escobido Angelica L. , Ramos Alysza Jane A. , Lopez Ethan Jay V. 
Published: May 2023

The number of retail pharmacies in Balingasag, Misamis Oriental have increased due to the promising economic development of the municipality. Despite customers having wide alternative options to choose, service quality-implementation by respective pharmacies have perhaps executed inconsistently leading to a poor outlook of the stores service. The main objective of this study is to assess the service quality and performance efficiency of pharmacies surrounding the central area of the municipality of Balingasag using Analytical Hierarchy Process (AHP). We discuss in this paper the analysis of criterion prioritization through expert judgments, identify retail pharmacies with high and low performance efficiency of service quality. Criteria considered in formulating the AHP architecture is based on the retail service quality scale of Dabholkar et al. (1996) including workplace hygiene, understanding, accessibility, reliability, guidance, policy, and problem – solving. Based on experts’ judgments using pairwise comparison, different performance indicators have been evaluated: the most prioritized criterion among the seven (7) criteria is ‘problem-solving’ with a criterion weight of 0.22 while the least prioritized criterion is ‘accessibility’ with a criterion weight of 0.05. Empirical evaluation integrated with the obtained criterion weights showed that among ten (10) retail pharmacies; nine (9) pharmacies have good performance quality, while the remaining pharmacy have an acceptable performance in service quality implementation. The result of this study gives emphasis that ‘problem-solving’ criterion in the implementation of service quality should be strengthened by retail pharmacies to subsequently improve its service quality performance and competitive positioning.
Implementation Of Educational Field Experience Program Activities In Schools With Motivation To Become Teacher In Pkk Program Students
Authors: Maiyandra Vera , Elida Elida 
Published: May 2023

This research was motivated by the unpleasant experiences that were obtained when students carried out the Educational Field Experience Program (PPLK) activities such as students in schools who lacked respect and respect, duties and responsibilities that exceeded the obligations of PPLK students and the time for implementing PPLK that exceeded PPLK standards. Based on the pre-research, there was a decrease in students' desire and interest to become teachers. This study aims to analyze the relationship between the implementation of the Educational Field Experience Program and the motivation to become a teacher for PKK UNP study program students in 2015 and 2016. This type of research uses correlational quantitative. The population in this study were 192 students of the Family Welfare Education study program who had carried out PPLK. For sampling is Proportional Random sampling with the results of 66 people. Data collection was carried out by means of a questionnaire via Google From using a Likert Scale that has been tested for validity and reliability. Data were analyzed using descriptive correlation with the help of SPSS 17 and MS. Excel. The results showed that PPLK data descriptions were in the very high category. For motivation to become a teacher it is in the medium category. The correlation coefficient of PPLK implementation results with motivation to become a teacher in PKK UNP students with a value of r count > r table of 0.465 > 0.242 which means the correlation coefficient is positive. If it is interpreted into the Interpretation criteria, the correlation coefficient is the value r, then the correlation coefficient is at a moderate level because the value of r is in the range 0.400 – 0.599 with a significance value of 0.000 <0.05 which means that Ha is accepted and tcount > ttable, 30.140 > 1.670 It can be concluded that Ha is accepted and Ho is rejected at a significance level of 0.05 and it can be stated that there is a significant and positive relationship between PPLK implementation and the motivation to become a teacher in family welfare education students at Padang State University. Keywords: