bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure Mechanisms and Constitutive Model of Composite Rock under Dynamic Loading
Authors: Li Jinyu , Zhao Hongbao , Ji Dongliang , Wan Huhu , Li Chen 
Published: January 2023

Abstract
In order to investigate the dynamic response characteristics of composite rock with different joint angles, static compression test and dynamic impact test are carried out using WDW-300E servo pressure-testing machine and split Hopkinson pressure bar (SHPB) test system. The dynamic compressive strength, energy dissipation, and failure modes are compared between rock coal (R-C) and coal rock (C-R). Furthermore, a 3D SHPB simulation system is constructed using coupling finite difference method and discrete element method (FDM-DEM) to reproduce the energy evolution and failure modes of composite rock with different joint angles, and the fabric tensor is obtained based on secondary development. Finally, a constitutive model of composite rock is established considering joint angles. The results of experiment, simulation, and theoretical analysis show that for the case of uniaxial compression test, with the increase of joint angle, the peak stress of composite rock shows obvious U-shaped change, and the elastic modulus increases gradually while the peak strain decreases gradually. For the case of dynamic impact test, the peak stress, strain, and energy dissipation values of composite rock decrease first and then increase with the increase of angle, and the elastic modulus of composite rock increases monotonically after a slight fluctuation of 30°. The stress, energy dissipation and elastic modulus of composite rock R-C are larger than that of composite rock C-R. However, the strain value of composite rock R-C is generally less than of composite rock C-R. The failure mode of composite rock with small and large angle is mainly splitting under dynamic impact, and the fracture fragmentation is relatively small with high energy absorption rate, while the fracture fragmentation is mainly shear and splitting mixed failure with low energy absorption rate. The energy accumulation and transformation process inside the composite rock are analyzed by 3D simulation system, and the damage of the composite rock under impact is mainly concentrated on the coal side, and peak values of contact number and contact force with different joint angles are calculated by using fabric tensor. Based on Weibull distribution, a constitutive model of composite rock is constructed considering initial damage and dynamic failure effect, which is in good agreement with experimental and simulation results, verifying the correctness of the constructed model.
Computational Fluid Dynamics Modeling of Pseudotransient Perforation Erosion in a Limited-Entry Completion Cluster
Authors: Kebert Brent A. , Miskimins Jennifer L. , Soehner Gage , Hunter William 
Published: January 2023

Summary
Hydraulic fracturing in limited-entry (LE) completion designs relies on maintaining a high bottomhole treating pressure (BHTP). LE requires high perforation friction to maintain an even distribution of the hydraulic fracturing slurry. As sand exits the perforations, the perforations start to erode. The erosional change in the perforation alters the desired perforation friction and subsequent BHTP. As operators rely on multistage hydraulic fracturing to generate economic production, the issue of perforation erosion becomes inherently repetitive from stage to stage and cumulatively a significant issue. The industry has seen how a perforation can change from a before-and-after perspective with downhole cameras and imaging techniques before and after treatments. However, a more detailed understanding of the dynamic process of perforation erosion can give a better expectation of perforation performance throughout a hydraulic fracturing treatment and not just pretreatment compared to post-treatment.
Computational fluid dynamics (CFD) is a quickly emerging tool in the industry. CFD aims to model fluid flow by numerically solving the Naiver-Stokes equations within a specified domain. Along with modeling fluid systems, CFD has the capability to model dispersed particles within the fluid. Once the particles are introduced into the fluid, the domain can also be eroded away within the CFD model. By utilizing the erosional capabilities of CFD, paired with the flow of a hydraulic fracturing slurry, perforation erosion can be investigated transiently throughout an entire hydraulic fracturing stage.
This work presents a better dynamic understanding of perforation erosion rather than just a “before vs. after” comparison. The CFD modeling methodology used to achieve the correct erosional pattern observed in the field is presented. Throughout this work, four different hydraulic fracturing completion parameters are investigated to determine the respective roles in perforation erosion. The four parameters include proppant size, proppant concentration, fracturing fluid viscosity, and proppant concentration ramping schedules. By investigating the impact that controlled design parameters have on perforation erosion, perforation erosion can be better anticipated to deliver improved completion results.
Determining Significant Factors Responsible for the Successful Managing of the Covid-19 Pandemic in Taiwan
Authors: Halide Halmar , Andika Andika , Wulandari Putri 
Published: January 2023

Abstract
The covid-19 pandemic badly affects most countries in the world both sociologically and economically. Taiwan, however, manages to handle its pandemic remarkably well before and after its Covid-19 cases spike. This paper aims to describe Taiwan's strategy for keeping the cases low and to identify significant factors related to this spike. These factors are found through the use of a stepwise regression model. The model inputs are 15 daily data sets that belong to the three grouped indicators: Containment and closures, Economic responses, and Health systems. In addition, the number of Covid-19 tests and changes in the number of people attending indoor and outdoor activities are also given as model inputs. The model output is the daily covid-19 confirmed cases. It is found that restrictions on the internal move, government campaign, debt or contract relief, indoor activities changes, work closures, and their interactions are amongst the most significant factors leading to the sharp jump in Covid-19 cases. The model is able to explain almost 88% of the cases. It is important that these factors are taken into consideration by any government in its preparation for an upcoming pandemic.
Addressing the gap for racially diverse research involvement: the King’s Model for Minority Ethnic Research Participant Recruitment
Authors: Chaudhuri K Ray , Podlewska Aleksandra , Lau Yue Hui , Gonde Chris , McIntosh Alysha , Qamar Mubasher A , O’Donoghue Simon , Larcombe Karen , Adeeko Maria , Gupta Atul , Bajwah Sabrina , Lafond Sarah , Awogbemila Olabisi , Coller Riaan van , Murtagh Ann-Marie , Ocloo Josephine Enyoam 
Published: January 2023

Abstract
Background
Ethnic minorities (EM) are still underrepresented in research recruitment. Despite wide literature outlining the barriers, enablers and recommendations for driving inclusion and diversity in research, there is still little evidence for successful diversity in research participation, which has a direct impact on the quality of care provided to ethnically diverse individuals.
Methods
In the light of the Covid-19 pandemic and the key public health need to address the disparity in care provided to non-white populations, we applied the recommendations made by Ocloo and Matthews (2016) on diverse engagement in PPI groups to promote inclusive research recruitment.
Results
Our results demonstrate a significantly higher recruitment of EM populations to studies, when compared to recruitment in years 2017–2020.
Conclusions
Enriched by additional recommendations based on our experiences during the Covid-19 research recruitment drive, we propose the King’s Model is used to support ethnically diverse research recruitment. Further evidence is needed to replicate our findings, although this preliminary evidence provides granular details necessary to address the key unmet need of validating clinical research outcomes in non-white populations.
Occurrence of Tick-Borne Pathogens in Ticks Collected from Cattle at Iringa and Kilombero District Councils, Tanzania
Authors: Magesa Walter , Haji Isihaka , Nzalawahe Jahashi S. , Kazwala Rudovick 
Published: January 2023

Abstract
Background
Ticks and tick-borne diseases undermine livestock production and productivity in Tanzania. Cattle in Tanzania are challenged by several tick species and tick-borne disease which are known to be endemic in cattle such as Anaplasmosis, Theileriosis and Babesiosis. However, there is insufficient information on tick and associated tick-borne pathogens in Tanzania. Therefore, this study was conducted to determine the occurrence of tick-borne pathogens including Anaplasma, Theileria and Babesia spp., in ticks from Kilombero and Iringa district councils of Tanzania.
Method
During January to August 2021, a repeated cross-section study was carried out and a total of 1,889 ticks were collected from 304 randomly selected cattle. The ticks were morphologically identified using morphological keys and a stereomicroscope. The identified tick species were grouped into 91 pools of 1–30 ticks according to species, sex, and collection site for analysis. The tick-borne pathogens were then detected from the tick pools using Polymerase Chain Reaction (PCR) targeting Anaplasma and Theileria or Babesia spp. Chi square/Fisher’s Exact test was performed to detect the difference between the proportion of pathogen positive tick pools in Iringa and Kilombero district councils and seasons.
Results
Overall, Anaplasma and Theileria/Babesia spp. were detected by PCR in (70.33%, n = 64) tick pools. The detection rate of both Anaplasma and Theileria/Babesia spp. was high in Amblyomma lepidum (25.00%, n = 16) followed by Rhipicephalus evertsi (23.44%, n = 15) tick pools. Tick pools from Iringa district had a significantly higher proportion of pathogen detection rate (91.04%, n = 61) as compared to Kilombero (12.50%, n = 3), (95% CI, p < 0.001). The co-infection rate of Anaplasma spp. and Theileria/Babesia spp. in all tick pools was (32.97%, n = 30). A significant higher co-infection rate of (43.28%, n = 29) was recorded in tick pools from Iringa district council (95% CI, p < 0.05).
Conclusion
The results showed a high tick-borne pathogen detection rate on tick pools collected from cattle from the study areas which might increase the risk of tick-borne diseases transmission and reduce animal production and productivity. Therefore, the ticks and tick-borne pathogens in the study areas highlight the need for strategic tick control approaches.
Mental health status of patients with a rare disease in consultation-liaison psychiatry service: Analysis of 22 patients with erythroderma
Authors: Duan Yanping , Wei Jing , Zhang Meng , Jiang Yinan , Geng Wenqi , Cao Jinya , Li Tao , Zhao Xiaohui , Qu Weixuan , Sun Ruixue , Hong Xia , Jin hongzhong 
Published: January 2023

Abstract
Background The mental health of patients with rare diseases deserves attention, but conducting the research is difficult. This study uses medical records of consultation-liaison psychiatry and provides the possibility of examining the mental health of patients with rare diseases.
Methods The medical records of patients diagnosed with erythroderma in the consultation-liaison psychiatry system of the Department of Psychological Medicine of Peking Union Medical College Hospital were analyzed.
Results Twenty two patients with erythroderma received psychiatric consultations during 2008 to 2021, and 8 patients (36.4%) were Beijing natives. The course of the disease ranged from 22 days to 33 years. Seven patients (31.8%) were diagnosed with erythroderma psoriasis. The common reasons for psychiatric consultation were anxious or depressive symptoms (10/22, 45.5%), insomnia (8/22, 36.4%), and disease pressure (4/22, 18.2%). The most common diagnosis were “depression”, “depressive state” or “anxious depression”, followed by “anxious state” or “anxiety”, “insomnia” and “delirium”. Antidepressants, benzodiazepines or nonbenzodiazepine sleep aids, and antipsychotics were prescribed. Five patients (22.7%) received only psychological counseling.
Conclusions Anxiety, depression and insomnia were common in patients with erythroderma. Patients with severe disease or elderly inpatients might present with delirium, which is a common reason for consultation-liaison psychiatry. Antidepressants, antipsychotics and sleeping aids arecommonly used in drug therapy. Resource-oriented psychological counseling was the most common intervention.
The dynamic changes of recurrent Immune reconstitution inflammatory syndrome of an AIDS patient with cytomegalovirus encephalitis and pulmonary tuberculosis：a case report
Authors: Song Shulin , Jiang Changyue , Gan Donghui , Lu Yibo 
Published: January 2023

Abstract
Background
This study describes an AIDS patient with central nervous systems tuberculosis, and cytomegalovirus infection who experienced immune reconstitution inflammatory syndromes associated to cytomegalovirus encephalitis and pulmonary tuberculosis while receiving antiretroviral therapy.
Case presentation
A 59-year-old male with fever of unknown origin with dizziness, fatigue, loss of appetite, fear of cold, occasional babbling during fever, and paroxysmal cough as the main symptoms three days was referred to our hospital Cerebrospinal fluid examination showed a cytomegaloviral load of 3.4×103 copies/ml and a positive mycobacterium tuberculosis recombination test. Cerebrospinal fluid gene X-pert MTB/RIF test showed mycobacterium tuberculosis infection without rifampicin resistance. Anti-tuberculosis treatment and anti-cytomegalovirus therapy were administered, and clinical and laboratory abnormalities were improved. The patient's CD4+ T lymphocyte count was 70 cells/μl, and antiretroviral therapy was started 24 days after the start of anti-tuberculosis treatment.
Clinical symptoms reappeared on day 33 after antiretroviral therapy treatment. Relapsing - immune reconstitution inflammatory syndrome was considered as the most likely diagnosis. After the addition of a small amount of dexamethasone to continue anti-tuberculosis and anti-cytomegalovirus therapy, the patient's symptoms disappeared and imaging was reduced in scope. There was no recurrence of clinical symptoms at 2 years of outpatient follow-up.
Conclusion
It is important to take aware of the emergence of multiple infections and the associated immune reconstitution inflammatory syndrome in AIDS. Once the immune reconstitution inflammatory syndrome manifests, a proper diagnosis and continual of treatment are imperative to the patient's recovery.
Simulation study and HSPICE modeling of single-event transients induced by secondary ions not incident to the drain in nanoscale CMOS technology
Authors: Wu Hao , Jin Gang , Yi Tengyue , Zhuang Yiqi 
Published: January 2023

Abstract
Terrestrial single-event transients (SETs) are mainly induced by secondary ions of neutron-induced nuclear reactions, which do not cross the sensitive drain in most cases. Technology computer-aided design (TCAD) simulations show that in those cases, both diffusion-collection current and burst-plateau-type current waveform could occur in nanoscale complementary metal-oxide-semiconductor (CMOS) technology. The necessity of including recombination effect in diffusion-collection model is identified, and an equivalent circuit model (ECM) is established to describe SETs induced by secondary ions with short distance to the drain. Both models are verified by TCAD simulations.
Jianpi Qinghua Sanyu Decoction attenuates insulin-like growth factor 1-induced GES-1 cell proliferation by suppressing the AKT pathway based on network pharmacology analysis
Authors: Liu Qihong , Zhao Peiling , Lin Xiaoying , Zhang Xinran , Wang Wenrong , Hu Jianyun , Chen Ying , Lin Lumin , Shen Aling , Ke Xiao 
Published: January 2023

Abstract
Raised erosive gastritis (REG) is a gastric mucosal lesion with characteristic radiological and endoscopic features. Jianpi Qinghua Sanyu Decoction (JPQHSYD) may be effective against REG, but its therapeutic effects and underlying molecular mechanisms have yet to be investigated. A network pharmacology analysis was performed to identify itsJPQHSYD active ingredients, potential targets, and pathways in REG treatment. Following database mining, our current study identified 245 compounds and 320 potential targets, as well as 94 common targets with REG. The construction of a traditional Chinese medicine (TCM) comprehensive network (Drug-Ingredients-Gene symbols-Disease network) identified ten potentially active compounds (including Quercetin) and 35 potential targets (including AKT1), as well as enriched signaling pathways (including cell proliferation and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt)). In vitro studies revealed that JPQHSYD significantly inhibits cell growth and viability while also down-regulating p-AKT, Bcl-2, CDK4, and CyclinD1 expression and up-regulating Bax protein levels in insulin-like growth factor 1 (IGF-1)-stimulated GES-1 cells. This study provides novel insights into the mechanism of action of JPQHSYD in REG treatment, implying that suppressing the AKT pathway may be one of the essential underlying anti-REG mechanisms of JPQHSYD.
Association Between Genetically Predicted Expression of TPMT and Azathioprine Adverse Events
Authors: Davis Alyssa , Dickson Alyson L. , Daniel Laura L. , Nepal Puran , Zanussi Jacy , Miller-Fleming Tyne W. , Straub Peter S. , Wei Wei-Qi , Liu Ge , Cox Nancy J. , Hung Adriana M. , Feng QiPing , Stein C. Michael , Chung Cecilia P. 
Published: January 2023

Abstract
Polymorphisms thiopurine-S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) can increase the risk of azathioprine myelotoxicity, but little is known about other genetic factors that increase risk for azathioprine-associated side effects. PrediXcan is a gene-based association method that estimates the expression of individuals’ genes and examines their correlation to specified phenotypes. As proof of concept for using PrediXcan as a tool to define the association between genetic factors and azathioprine side effects, we aimed to determine whether the genetically predicted expression of TPMT or NUDT15 was associated with leukopenia or other known side effects. In a retrospective cohort of 1364 new users of azathioprine with EHR-reported White race, we used PrediXcan to impute expression in liver tissue, tested its association with pre-specified phecodes representing known side effects (e.g., skin cancer), and completed chart review to confirm cases. Among confirmed cases, patients in the lowest tertile (i.e., lowest predicted) of TPMT expression had significantly higher odds of developing leukopenia (OR=3.30, 95%CI: 1.07-10.20, p=0.04) versus those in the highest tertile; no other side effects were significant. The results suggest that this methodology could be deployed on a larger scale to uncover associations between genetic factors and drug side effects for more personalized care.
Low-Level Vertical Structure of Cross-Equatorial Flows in Boreal Summer
Authors: Zhang Xinming , SUBRAHMANYAM M. V. 
Published: January 2023

Abstract

Cross-equatorial flows (CEFs) are critical channels for mass, momentum, and water vapor exchange between the southern and northern hemispheres and have considerable influence on the global air-sea system. This study uses ERA-5 reanalysis data to find the relationship between vertical structure characteristics of global low-level CEFs in boreal summer and their correlation with sea surface temperature (SST). The research demonstrates that the vertical structure of CEFs is independent. The windspeed core is mainly at 925hPa or 1000hPa, and the vertical structure of CEFs has an obvious correlation. Through EOF analysis, two main vertical structures of the eastern hemisphere's CEFs are obtained: "consistent variation " and "opposite variation. " The vertical structures of the western hemisphere only have "opposite variation "and have greater longitude spans with tinner southerly wind thickness. The correlation analysis between CEFs and SST indicates Pacific Decadal Oscillation, two types of ENSO, and SST variations in the Indian and central Pacific oceans. SST variations can relate to the vertical structure change of CEFs.
A nomogram based on imaging features and serological indicators for predicting efficacy of neoadjuvant chemotherapy in gastric cancer
Authors: Zhou Jie , Wang Haitao , Ding Wei , Feng Yuehua , Xin Zhaoyu , Liu Zhilin 
Published: January 2023

Abstract
Background Neoadjuvant chemotherapy (NAC) has been proven to be a powerful therapeutic choice for the advanced gastric cancer. However, the overall response rate is only 20-40% and there is a lack of sensitive indicators to predict the efficacy of the therapy. In this study, we aimed to construct a nomogram to predict the efficacy of NAC for gastric cancer.
Method The study comprised 60 gastric cancer patients who underwent NAC. Patients were classified into effective (TRG 0-2) and ineffective (TRG 3) groups based on the Tumor Regression Grade (TRG). Clinical data were compared between the two groups, and binary logistic regression analysis was used to screen the independent factors that could predict efficacy. Then, a new nomogram was created and validated.
Result In this study, a total of 33 patients (33/60, 55%) were successfully treated with NAC. Platelet Distribution Width, Adenosine Deaminase, Urea, and clinical T-stage of tumor were independent factors for predicting the efficacy of NAC for gastric cancer treatment (P < 0.05). The consistency index of the constructed Nomogram was 0.923 (95% CI: 0.851-0.995).
Conclusion The nomogram developed in this study has a high degree of clinical utility, calibration and discrimination, which can help clinicians accurately predict the efficacy of NAC for gastric cancer patients.
IGF2BP2-meidated m 6 A modification of CSF2 reprograms MSC to promote gastric cancer progression
Authors: Ji Runbi , Wu Chenxi , Lin Jiang , Gu Hongbing , Fu Min , Zhang Xiaoxin , Li Yongkang , Xu Jiajin , Zhang Xu 
Published: January 2023

Abstract
Background
The interaction between tumor cells and stromal cells in tumor microenvironment is critical for cancer progression. MSCs represent a dominant source of tumor stromal cells and exert pro-oncogenic activities when reprogrammed by tumor. The precise mechanism for MSC reprogramming in gastric cancer has not been fully understood.
Methods
The gene and protein expression levels were examined by qRT-PCR, western blot, and immunohistochemistry. The biological functions of gastric cancer cells were detected by in vitro and in vivo experiments. RNA‐sequencing, RNA immunoprecipitation (RIP), and meRIP assays were conducted to explore the potential regulatory mechanisms.
Results
We identified that the expression and N6-methyladenosine (m6A) modification levels of colony stimulating factor 2 (CSF2) were significantly increased in gastric cancer MSCs. CSF2 upregulation and stimulation induced the reprogramming of normal MSCs to cancer-promoting MSCs, which promoted the proliferation, migration, and drug resistance of gastric cancer cells through the secretion of various pro-inflammatory factors. We further demonstrated that CSF2 mRNA was recognized and stabilized by m6A reader IGF2BP2, whose overexpression mimicked the effect of CSF2 on MSCs to promote gastric cancer progression. Finally, we found that CSF2 exerted the reprograming effect of MSCs by inducing the ubiquitination of Notch1.
Conclusions
The increased m6A modification of CSF2 by IGF2BP2 reprogrammed MSCs into a cancer-promoting phenotype. The IGF2BP2/CSF2/Notch1 axis represents a new mechanism for MSC programming in gastric cancer and offers a novel target for gastric cancer therapy.