bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioequivalence study of generic nirmatrelvir in healthy volunteers
Authors: Oseshnyuk R. A. , Nikiforova A. G. , Boroduleva A. Yu. , Sobolev P. D. , Lesnichuk S. A. , Garyaev B. B. , Abramova A. A. , Mozgovaya V. G. , Filon O. V. , Zinkovskaya A. V. , Dolgorukova A. N. , Khanonina E. K. , Ignatiev V. G. , Samsonov M. Yu. 
Published: May 2023

Nirmatrelvir is an antiviral drug that, in combination with ritonavir, is an effective agent for the etiotropic therapy of patients with mild to moderate COVID-19.The aim of the study was to evaluate bioequivalence of the generic drug nirmatrelvir Аrpaxel in combination with ritonavir and the original drug Paxlovid, which is a combination of nirmatrelvir/ritonavir, in a single dose administration to healthy volunteers.Materials and methods. This research was an open-label, randomized, two-period crossover bioequivalence study. It included 2 periods, in each of which the volunteers received either a test drug (nirmatrelvir at the dose of 300 mg) in combination with ritonavir (100 mg), or a reference drug (a combination of nirmatrelvir 300 mg and ritonavir 100 mg), given as a single dose. A wash-out period between each of the administrations was 7 days. The blood sampling to determine the concentration of nirmatrelvir was carried out in the range from 0 to 36 h in each of the study periods. A nirmatrelvir concentration was determined by a validated HPLC-MS/MS method with a lower quantitation limit of 10 ng/mL. Bioequivalence was assessed by comparing 90% confidence intervals (CIs) for the ratio of geometric means of AUC(0–16) and Cmax of the test drug and reference drugs with the established equivalence limits of 80.00–125.00%.Results. In the study were included 68 healthy volunteers, 67 participants of which were included in the bioequivalence population. The pharmacokinetic parameters of the drugs were comparable to each other. The 90% confidence interval for the ratio of the geometric mean of the maximum drug concentration in the blood plasma and the area under the pharmacokinetic curve «concentration-time» from zero to the last blood draw within 36 hours of nirmatrelvir was 87.26–100.83 and 93.27–103.74%, which meets the criteria for assessing bioequivalence. The test drugs were well tolerated by the volunteers. The incidence of adverse events was similar for the test and reference drugs. No serious adverse events were recorded during the entire study.Conclusion. As a result of this study, bioequivalence of the test and reference drugs has been established.
Analysis of the Dynamics of Water Flow and Suspension Flow Discharge in Volcano Watershed with Settlement Land Use
Authors: Hadini La Ode , Sartohadi Junun , Setiawan Muhammad Anggri , Mardiatno Djati , Crhristanto Nugroho 
Published: May 2023

Suspension flow into the upstream of volcano watershed is sensitive to land use. In Indonesia, a settlement is a form of land use in several volcanic landscapes. There is currently no detailed study on the suspension flow sediment from the settlement land use. The purpose of this study is to investigate the characteristics of the relationship between water and suspension flow discharge. The study was conducted through the measurements at a gully outlet that produced 747 suspension load data. For each rainfall event, suspension load measurements were made in the field, followed by laboratory analysis. Additionally, field surveys were used to determine the characteristics of settlement land use and the water flow into the gully system. According to the findings, the peak flow discharge corresponds to the peak suspension discharge, the peak flow discharge comes before the peak suspension discharge, and the peak flow discharge happens after the peak suspension discharge. The average time lag between initial rainfall events and suspension flow was 10.36 minutes, and the suspension peak content varied by an average of 2.22 gl-1. The grain size was also dominated by the clay fraction, averaging 67.86% on the ascending branch and 67.82% on the descending branch.
Keywords: Erosion; Discharge; Settlements; Suspension; Watershed

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Farmers Participation in Applying Silvopasture Technology for Organic Fertilizer Production as A Sustainable Agriculture
Authors: Sumarmi Sumarmi , Masruroh Heni , Bachri Syamsul , Suprianto Agung 
Published: May 2023

Medowo Village is a potential location for plantings due to its location on the slopes of Mount Anjasmoro in Kandangan District, Kediri Regency. Moreover, Medowo Village is renowned for its dairy for cows and goats. This research aimed to determine the type and level of participation in the production of organic fertilizers to support in sustainable agriculture. This research used a qualitative approach and descriptive method. The data was collected through in-depth interviews, participatory observation, and documenting. The identification of key informant was using the purposeful snowball throwing technique. Data analysis used reduction, display, and verification, as well as data validation through Focus Group Discussion (FGD). The discussion was conducted with 20 farmers, with the main topics related to: a) the problem of fertilizer needs in Medowo Village, and b) producing fertilizer for sustainable farming using the Shivansh fertilizer method. According to the results, there were four stages of farmer participation: 1) planning, 2) implementation, 3) utilization of results, and 4) evaluation. The findings indicated that the level of farmer participation is classified as "good" for all stages. Participation is demonstrated specifically by attendance, participation, and enthusiasm. High participation is found mostly in stages that include activities in producing the . Therefore, inviting farmers at the planning stage is essential to increase participation in program.
Keywords: Agriculture; Organic fertilizer; Participation; Sustainable

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Analysis of Sea Surface Dynamics during the Coastal Floods in Manado
Authors: Azani Audia Azizah , Efendi Usman 
Published: May 2023

Coastal flooding is one of the serious problems facing most coastal areas in the world. On January 17 and December 7, 2021, coastal flooding hit the coastal area of Manado, North Sulawesi, Indonesia. The disaster disrupted economic activities on the coast of Manado Bay. This study analyzed the dynamics of the atmosphere and the sea during coastal flood events using water level data from the Geospatial Information Agency, which was then filtered to separate residual and atmospheric tide, and oceanographic reanalysis data of Wavewatch-III from BMKG Ocean Forecast System (OFS). The results show that events on January 17 and December 7, 2021, coincided with the occurrence of the maximum tide. The residual water level shows a significant value of around 0.2 – 0.3 m, indicating the influence of atmospheric phenomena on sea level rise. According to oceanographical data, the local wind is the main factor of flood occurrence, which is shown by wind speed data which increased wave height significantly to 1,5 m on January 17, 2021, and to 2,0 m on December 7, 2021, around Manado Bay coast. Another factor that might contribute to the event is Manado's land morphology. Further study must be conducted to discover the influence of land morphology on coastal floods.
Keywords: Coastal flood; Water level; Tide

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
LEARNING PHYSICS THROUGH COMICS MEDIA: AN ENHANCEMENT OF NEWTON LAW TOPICS ON ONLINE LEARNING
Authors: Zahartian Syarif Eko , Junus Muhammad , Sulaeman Nurul Fitriyah 
Published: May 2023

Comics are visual media to convey messages entertainingly so that they can be used in education and have become a tool that can promote the enjoyment of learning. This study aims to explore students' learning outcomes on Newton's Law material when using comic-based learning media. This study uses a quasi-experimental design method in the form of a non-equivalent control group design. The population in this study are all students of class X MIPA of SMAN 1 Muara Badak in the 2021/2022 academic year, where the sample used is class X MIPA 2 as the experimental class and class X MIPA 3 as the control class. The experimental class applies comic-based learning media, and the control class uses conventional learning media. The data were collected using pre-test and post-test and then analyzed using the n-gain and independent t-test analysis. This study has established that comic-based learning media is better than conventional learning media. The results showed a significantly different learning outcome between the experimental and the control classes with the acquisition of sig-2 tailed 0.000. In addition, the results of the assessment also showed an increase in student learning outcomes, seen from the results of the n-gain test, where the experimental class showed a higher accumulation of 0.3779 and entered the average category compared to the control class, which was only 0, 1090, which is in the low category. Based on these results, comics could be a supportive media to learn physics at the high school level.
Time estimation for mating peak and calving of Bali cattle in semi-arid area in Netemnanu village Kupang district
Authors: Marianus Yakobus Magul Datur  , Tarsisius Considus Thopianong  , Cynthia Dewi Gaina  , Nancy Diana Federika Katarina Foeh  
Published: May 2023

Bali cattle have advantages in terms of adaptation and fertilization rates, but tend to have slow growth rate because the rearing system is still grazing so that livestock growth becomes uncontrollable. This study aims to determine the peak of mating and calving estimation of Bali cattle (Bos sondaicus) that did not experience reproductive disorders, aged 4-7 years, belonging to smallholder farmers. The cattle were reared in semi-arid area of Netemnanu village, South Amfoang district, Kupang regency, Nusa Tenggara Timur. The method used was interviews with farmers, diagnosis of pregnancy through rectal palpation and ultrasonography. The results showed that the pregnancy rate was 86.20% (50/58). Based on pregnancy data, it was known that the peak of mating would occur in December 2021 and estimated calving would reach its peak in September 2022.
A Meta-Analysis of 80% Fraction of Inspired Oxygen on Surgical Site Infection in Patients Undergoing Surgery
Authors: Erisadana Rifaldy Nabiel , Tohari Achmad Ilham , Supranoto Yehuda Tri Nugroho , Utami Wiwien Sugih , Indreswari Laksmi 
Published: May 2023

<p><strong>Background:</strong> WHO recommended the use of 80% FiO<sub>2</sub> in patients undergoing general anesthesia with endotracheal intubation (ETI) to prevent surgical site infection (SSI). However, the ongoing debate regarding efficacy and safety raises because further trials have been published. We conducted a review based on recommendations in terms of SSI as the primary outcome and adverse events as the secondary outcome in both patients with or without ETI.</p><p><strong>Method:</strong> A literature search was carried out by PubMed, ScienceDirect, and Google Scholar for RCTs in all-type surgical patients who administrated 80% FiO<sub>2</sub> compared with 30–35% FiO<sub>2</sub>. Pooled relative risks with a 95% confidence interval were conducted for meta-analysis. <strong>Result:</strong> Based on 23 RCTs included in the analysis, there were no significant differences in terms of SSI (RR,0.85; 95%CI, 0.72 to 1.01; p=0.07), sepsis (RR,1.47; 95%CI, 0.78 to 2.76; p=0.23), postoperative hospitalization days (PHD) (RR,0.16; 95%CI, -0.67 to 0.98; p=0.71), ICU admission (RR,0.94; 95%CI, 0.78 to 1.13; p=0.50), reoperation required (RR,0.78; 95%CI, 0.30 to 2.06; p=0.62), and 30-days mortality (RR,1.18; 95%CI, 0.76 to 1.84; p=0.45). In contrast, even though the subgroup analysis showed association that PHD longer in high FiO<sub>2</sub> group for colorectal surgery (RR,0.80; 95%CI, 0.24 to 1.35; p=0.005), the high FiO<sub>2</sub> significantly reduced SSI and anastomotic leakage in abdominal surgery (RR,0.78; 95%CI, 0.62 to 0.99; p=0.04 and RR,0.55; 95%CI, 0.36 to 0.85; p=0.008).</p><p><strong>Conclusion:</strong> This meta-analysis provides evidence that administration of 80% FiO<sub>2</sub> even though association with longer of PHD in colorectal surgery, it is associated with a reduction in SSI and anastomotic leakage in patients who underwent abdominal surgery. It contrasts for sepsis, ICU admission, reoperation required, 30-day mortality, SSI, and PHD in all-type surgery. </p>
IMPLEMENTASI BAYANI, IRFANI, BURHANI TERHADAP PENDIDIKAN KARAKTER SANTRI DALAM SISTEM PENDIDIKAN DI PESANTREN
Authors: Amrullah Muhammad Afif , B.K.P.S Alaika Muhammad , Fawaid Imam , Alfaruq Moch Ishaq 
Published: May 2023

Regarding theiproblem of life, moral degradation is often heard in the body of the next generation of the nation. Starting from small children, adults, to the erderly. Today’s formal education tens to present learning materials based on intellectual intelligence, while in everyday life emotional intelligence and spiritual intelligence are needed. With the concept of marginal understanding, there will be a gap because someone's understanding is cognitively different. Especially now that it is supported by technological advances that are free to erode understanding of character. This then forms a character in a person because of his ability to internalize it. A person's character will experience ups and downs when theory is only used as a starting point in behavior.
Through analysis Bayani, Irfani, and Burhani will describe how it is implemented in the education system. The method used is library research , in which the orientation is to examine books, manuscripts, and literature relevant to the object of research. The results of this study conclude that the education system in Islamic boarding schools is not only based on theory but habituation. The pesantren environment that brings them to study does not only apply knowledge through doctrination, but in actualization in their lives as santri. This can be seen through several phenomena that occur such as gangsters, fights between students, until narcotics are also found in young people. And this is rarely found for those who are in dormitories or from pesantren graduates.
Keywords: Bayani, Irfani, Burhani, Character, Islamic Boarding School
REVITALISASI KURIKULUM LEMBAGA PENDIDIKAN AL WASHLIYAH DALAM MELAHIRKAN ULAMA
Authors: Napitupulu Dedi Sahputra 
Published: May 2023

Ciri khas dari organisasi Islam Al Washliyah adalah lembaga pendidikannya yang berorientasi pada tradisi keulamaan. Penelitian ini bertujuan untuk menganalisis revitalisasi kurikulum lembaga pendidikan Al Washliyah dalam melahirkan ulama. Penelitian ini menggunakan metode kualitatif lapangan dengan menggunakan teknik observasi, wawancara dan studi dokumen. Hasil penelitian ini menunjukkan bahwa Al Washliyah secara khusus telah mendirikan lembaga Pendidikan Kader Ulama (PKU) yang dikelola oleh Fakultas Agama Islam UNIVA Medan. Kurikulum yang diterapkan adalah dengan tetap memelihara kurikulum pendidikan Al Washliyah dimasa lalu yang dominasi pelajaran agama ditambah dengan pelajaran umum sesuai dengan kurikulum pendidikan nasional yang berlaku. Sedangkan metode yang digunakan adalah dengan mengkombinasikan metode moderen dan klasik (kitab kuning dan halaqah).
INCLUSIVE MADRASAH: CONCEPTS, APPROACHES, AND POLICIES
Authors: Anshari M. 
Published: May 2023

One of the stigma and prejudice on people with disabilities arise in the educational setting, madrasah as Islamic educational institutions have contributed to exclusion and marginalization of muslim student with disabilities. Referring to the source from the education Management information System (EMIS) of The Kementerian Agama of the Republic of Indonesia in 2021 its shows the number of Madrasah in Indonesia 83,648 madrasah, there are only several of madrasah that have implemented inclusive madrasah. This paper focuses on inclusive education in the context of Islamic educational institutions in madrasah, which is related to policies, concepts, and practices. Concepts and practices that have been carried out by a number of madrasah that provide inclusive education grow and develop bottom-up from practitioners and parents who have children with disabilities, and have been carried out by a number of madrasah that provide inclusive education grow and develop top down The Kementerian Agama of the Republic of Indonesia appointed several madrasas as piloting projects for inclusive madrasah. This article attempts to review various studies regarding inclusive madrasah in Indonesia as the concepts, approaches and policies.
Results on a Pre-T_2 Space and Pre-Stability
Authors: Jasim Anmar Hashim 
Published: May 2023

This paper contains an equivalent statements of a pre- space, where are considered subsets of with the product topology. An equivalence relation between the preclosed set and a pre- space, and a relation between a pre- space and the preclosed set with some conditions on a function are found. In addition, we have proved that the graph of is preclosed in if is a pre- space, where the equivalence relation on is open.
On the other hand, we introduce the definition of a pre-stable ( pre-stable) set by depending on the concept of a pre-neighborhood, where we get that every stable set is pre-stable. Moreover, we obtain that a pre-stable ( pre-stable) set is positively invariant (invariant), and we add a condition on this set to prove the converse. Finally, a relationship between, (i) a pre-stable ( pre-stable) set and its component (ii) a pre- space and a (positively critical point) critical point, are gotten.
Prevalence and Risk Factors of Bovine Tuberculosis in Cattle in Selected Districts of Fafan Pastoral Settings, Eastern Ethiopia
Authors: Hussein Hassan Abdi , Musse Abdi Hussein 
Published: May 2023

Abstract
Cross-sectional study was conducted from October 2021 to August 2022, to investigate the prevalence and associated risk factors of bovine tuberculosis in cattle in selected districts of Fafan zone. The prevalence was 11.24% (95% CI, 8.61-14.35) and 43.3% (95% CI, 33.27-53.75) at individual and herd level respectively. There were statistically significant differences in proportions of positive reactor animals among body condition score (χ2 = 47.9, P = 0.000), Age (χ2 =6.0937, P=0.048), Seasonal migration (χ2=4.320, P=0.038), parity number (χ2 = 10.62, P = 0.005), reproductive status (χ2 = 4.36, P = 0.037). Animals with poor body condition scores had a significantly higher likelihood of testing positive, with their odds being 11.4 times greater (COR=11.408, CI=3.43-37.94, P<0.001). Conversely, a good body condition score was linked to a decreased risk of infection. In multivariate logistic regression poor body condition score remained significantly associated with the odds of reacting positive for tuberculosis (AOR=0.137, CI=0.053-0.356, P<0.001). Similarly, the analysis showed that seasonal migration (AOR=2.935, CI=1.152-7.481, P=0.024), and parity number (AOR=11.91, CI=1.828-77.62, P=0.010), were significant predictors of bovine tuberculosis infection in cattle. According to questionnaire, 14.2% (17 of 120) and 13.3% (16 of 120) of the respondents were knowledgeable about bovine tuberculosis and its transmission from animal to human and vice versa, respectively. The general judgment of herders' understanding of bovine tuberculosis transmission methods to humans was very low. Study findings show high prevalence of bovine tuberculosis in the study area, emphasizing the need for an effective control strategy.
The role of human endometrial stem cells application in endometrial-factor induced infertility
Authors: Bausyte Raminta , Vaigauskaite Brigita , Borutinskaite Veronika , Valatkaite Elvina , Besusparis Justinas , Valkiuniene Ruta Barbora , Kazenaite Edita , Ramasauskaite Diana , Navakauskiene Ruta 
Published: May 2023

Abstract
Background.
Endometrial-factor induced infertility remains one of the most significant pathology among all fertility disorders. Stem cell-based therapy is considered to be the next-generation approach. However, at this point there are still issues about successfully retrieving human endometrium derived stem cells (hEnSCs). Moreover, we also need to establish a better understanding of the effect of hEnSCs on the endometrial recovery and the clinical outcome.
Methods.
Endometrium samples were collected from females undergoing assisted reproductive technology (ART) procedure due to couple infertility. These samples were obtained using an endometrium scratching. The hEnSCs were isolated from endometrium samples and characterized with flow cytometry analysis. Groups of endometrium injured female mice were established by the mechanical injury to uterine horns and the intraperitoneal chemotherapy. The hEnSCs suspension was injected to some of the studied female mice at approved time intervals. Morphological changes of mice uterine horns were evaluated after Masson‘s trichrome original staining and hematoxylin and eosin (H&E) staining. The fertility assessment of mice was performed by counting formed embryos. The expression of fibrosis related genes (Col1a1, Col3a1, Acta2 and CD44) was evaluated by the reverse transcription – quantitative polymerase chain reaction (RT-qPCR).
Results.
Endometrium scratching is an effective procedure for stem cells collection from human endometrium. Isolated hEnSCs met the criteria for defining mesenchymal stem cells (MSCs). Moreover, hEnSCs-based therapy had a demonstrably positive effect on the repair of damaged uterine horns layers, including a reduction of fibrosis, intensity of inflammatory cells such as lymphocytes and polymorphonuclear cells (PMNs) and the number of apoptotic bodies. The injured female mice had higher fertility after hEnSCs-based therapy in comparison to the untreated mice models. Gene expression was also reflected in morphology changes and outcomes of conception.
Conclusions.
hEnSCs demonstrated a positive impact on endometrium restoration and outcomes of endometrial-factor induced infertility. Further exploration is required in order to continue exploring the multifactorial associations between stem cell therapy, gene expression, endometrial changes and reproductive health, so we can identify individually effective and safe treatment strategies for endometrial-factor induced infertility, which is caused by mechanical effect or chemotherapy, in daily clinical practise.