bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI-based Solution for Improving Neuroradiology Workflow for Cerebrovascular Structure Monitoring
Authors: Banerjee Subhashis , Nysjö Fredrik , Toumpanakis Dimitrios , Dhara Ashis Kumar , Wikström Johan , Strand Robin 
Published: January 2023

Abstract

Radiological examination of the intracranial cerebrovascular structure is crucial for pre-operative planning and post-operative follow-up. Volumetric visualization generated by computerized segmentation of the cerebrovascular structure from Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) is an appealing alternative for radiologists. This paper presents a topology-aware learning strategy with a Decorrelation Loss (DcL) for volumetric segmentation of intracranial cerebrovascular structures from multi-center MRAs. A multi-task deep CNN along with a topology-aware loss function is proposed to learn voxel-wise segmentation of the cerebrovascular tree. Domain regularization for the encoder network is achieved through Decorrelation Loss. Auxiliary tasks provide additional regularization and allow the encoder to learn higher-level intermediate representations to boost the performance of the main task. The proposed method is compared with six state-of-the-art deep learning-based 3D vessel segmentation methods. Retrospective TOF-MRA datasets with and without vascular pathologies, collected from multiple private and public data sources scanned at six different hospitals are used to perform the experiments. We have also developed an AI-assisted Graphical User Interface (GUI) based on the proposed research to assist radiologists in their daily work and establish a time-saving work process.
Effects of drought-rewetting process and salinity variations on DOM transformation and bacterial communities in lacustrine sediments
Authors: Zhu Xiang , Xie Lei , Ma Yushen , Wang Longmian , Pang Qingqing , Peng Fuquan , Xu Zhipeng , Xu Bin , He Fei , Ni Lixiao , Wang Ling 
Published: January 2023

Abstract

Climate change and anthropogenic activities cause salinity fluctuations and frequent drought-rewetting process in lacustrine littoral zones. However, joint effects of these processes on quality and quantity of dissolved organic matter (DOM) in pore water and bacterial communities in sediments are not well understood. An experiment was conducted to attempt to fill the above gaps, the results showed that the joint effects of higher salinity (6,000 mg/L) and drought-rewetting process were to retain more humified, more aromatic, and less bioavailable DOM, and to maintain lower DOM concentrations in pore water. The drought-rewetting process magnified influence of salinity on bacterial communities. Before the drought-rewetting process, Hydrogenophilaceae, Oxalobacteraceae, and Flavobacteriaceae participated in the DOM transformation, while Hydrogenophilaceae, Desulfobacteraceae, Anaerolineacea, Planococcaceae, and Clostridiaceae were associated with DOM components after this process. The drought-rewetting process greatly increased significant positive correlations (P<0.05) among bacteria, which was consistent with Stress Gradient Hypothesis and destabilized the bacterial communities. Higher (6,000 mg/L) or lower (1,200 mg/L) salinity were all not conducive to stability of bacterial communities in Shahu Lake. The results of this study may provide ideas for further investigating DOM transformation and cycling in brackish-water lakes.
Physiological traits and expression profile of genes associated with nitrogen and phosphorous use efficiency in wheat
Authors: Sagwal Vijeta , Kumar Upendra , Sihag Pooja , Singh Yogita , Balyan Priyanka , Singh Krishna Pal 
Published: January 2023

Abstract
Background Nitrogen (N) and phosphorous (P) play a very important role in growth and development of wheat as well as major constituents of biological membrane. To meet the plant nutritional demand these nutrients applied in the form of fertilizers. But plant can utilize only half of the applied fertilizer whereas rest is lost thorough surface run off, leaching and volatilization. Thus, to overcome the N/P loss we need to elucidate the molecular mechanism behind the N/P uptake.
Methods In our study, we used DBW16 (low NUE), and WH147 (high NUE) wheat genotypes under different doses of N, whereas HD2967 (low PUE) and WH1100 (high PUE) genotypes were studied under different doses of P. To check the effect of different doses of N/P, the physiological parameters like Total chlorophyll content, net photosynthetic rate, N/P content, and N/PUE of these genotypes were calculated. In addition, gene expression of various genes involved in N/P uptake, utilization, and acquisition were studied by quantitative real time- PCR.
Results Statistical analysis revealed a lower percent reduction in TCC, NPR, N/P content in N/P efficient wheat genotypes (WH147 & WH1100). A significant increase in relative fold expression of genes under low N/P concentration was observed in N/P efficient genotypes as compared to N/P deficient genotypes.
Conclusion Significant differences in physiological data and gene expression among N/ P efficient and deficient wheat genotypes could be useful for future improvement of N/P use efficiency.
Phylogenetic Analysis of Impatiens in the Eastern Yunnan, China
Authors: Li Fan , Zhao Rui , Li Yang , Li Xinyi , Wei Chunmei , Zhang Xiaoli , He Haihao , Qu Suping , Huang Meijuan , Huang Hai Quan 
Published: January 2023

Abstract

Impatiens L. is a genus of complex taxonomy that belongs to the family Balsaminaceae (Ericales) and contains approximately 1000 species. In this study, ISSR, trnL-trnnF, atpB-rbcL and DEF four molecular markers were used to analyze the genetic diversity and phylogenetic relationships among 32 species of Impatiens from eastern Yunnan. The results showed that the genetic similarity coefficient (GS) of these Impatiens resources ranged from 0.540 to 0.990, it indicated that the genetic diversity was relatively rich. However the genetic distance was relatively vague, and the evolutionary relationship was not obvious, which the phylogenetic trees were constructed by using the chloroplast genes atpB-rbcL and trnL-trnF. The genetic distance of the phylogenetic tree constructed by the DEF gene was relatively clear, the evolutionary relationship was obvious, and the result was consistent with ISSR. This indicated that DEF gene was greatly affected by plant habitat, and had abundant variation and a fast evolution rate, while atpB-rbcL and trnL-trnF genes had a slower evolution rate. And it was discovered that the flower morphological traits of the genus Impatiens can be employed as significant categorization markers. In particular, the wing shape can be used as an important flower morphological feature for the classification of the genus Impatiens in eastern Yunnan; and the results of using ISSR and DEF gene markers and flower morphological characteristics were consistent with the results of the interspecies division of Impatiens in this region. This study provided new basic data and a scientific basis for the protection, sustainable development, and utilization of Impatiens plant resources and genetic breeding in this region.
Analysis of mud rheological characteristics based on debris flow migration process
Authors: Xianjun Ji , Ying Liang 
Published: January 2023

Abstract
The rheological characteristics of debris flow are the basis of the analysis of debris flow initiation, migration and deposition process. In order to explore the rheological characteristics of debris flow mud, according to the shear characteristics of debris flow fluid in different stages, taking Nanyang expansive soil mud as experimental material and using mcr702 rheometer blade rotor system, rheological experiments (twice increasing shear and once decreasing shear) were carried out on mud with different solid volume concentrations. According to the experimental results, the effects of different experimental processes and solid volume concentration on mud rheological parameters are analyzed, and the following conclusions are obtained: In the process of increasing shear rate, when the shear rate is less than 0.002s-1, the first shear stress is lower than the second shear stress; However, the first shear stress is higher than the second shear stress if the shear rate exceeds 0.002s-1. When the shear rate is greater than 1.83s-1, the mud is in the stable flow stage, the shear stress has a power-law relationship with the shear rate, and its rheological parameters increase exponentially with the volume concentration of mud. In the process of decelerating shear, the shear stress decreases in power law with the decrease of shear rate, which is a group of parallel lines in the double logarithmic coordinate system. Its flow index is less affected by solid volume concentration. The static yield stress of mud (the peak shear stress of the first increasing speed) is much larger than the stable flow yield stress (the shear stress value corresponding to the critical shear rate of 1.83s-1), and the difference decreases with the decrease of the volume concentration of mud solids. The static yield stress and steady flow yield stress of mud increase exponentially with the volume concentration of solid.
Eicosanoid and Eicosanoid-Related Inflammatory Mediators and Exercise Intolerance in Heart Failure with Preserved Ejection Fraction
Authors: Lau Emily , Roshandelpoor Athar , Zarbafian Shahrooz , Wang Dongyu , Guseh James , Allen Norrina , Varadarajan Vinithra , Lima João A.C. , Shah Sanjiv , Yu Bing , Alotaibi Mona , Cheng Susan , Jain Mohit , Lewis Gregory , Ho Jennifer 
Published: January 2023

Abstract
Background: Systemic inflammation has been implicated in the pathobiology of HFpEF. We examined the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites with HFpEF status and exercise manifestations of HFpEF.
Methods: We studied 510 participants with chronic dyspnea and preserved LVEF who underwent invasive cardiopulmonary exercise testing (CPET). We examined the association of 890 eicosanoid and eicosanoid-related metabolites ascertained using mass spectrometry with HFpEF status (defined as abnormal rest or exercise PCWP) using multivariable logistic regression (FDR q-value <0.1 deemed significant). In secondary analyses, we examined eicosanoid profiles of specific exercise traits, including cardiac vs extra-cardiac organ reserve using principal component analysis. To corroborate findings, significant metabolites were tested against incident HF in 5192 MESA participants.
Results: Among 510 participants (mean age 56±16 years, 63% women), 257 had physiologic evidence of HFpEF. We found 70 eicosanoid and eicosanoid-related metabolites were associated with HFpEF status including 17 named and 53 putative eicosanoids and eicosanoid-related metabolites. Specific prostaglandin (15R-PGF2a and 11ß-dhk-PGF2a) and linoleic acid derivatives (12,13 EpOME) were associated with greater odds of HFpEF, whereas epoxide (8(9)-EpETE), docosanoid (13,14-DiHDPA), and oxylipin (12-OPDA) derivatives were associated with lower odds of HFpEF(P<0.008 for all). Eicosanoid profiles showed heterogeneous associations across cardiac vs extra-cardiac contributors to exercise intolerance. In the MESA sample, we found that 18 eicosanoids and eicosanoid-related metabolites were associated with the development of future heart failure (P<0.05 for all).
Conclusions: We found 70 pro- and anti-inflammatory eicosanoid and eicosanoid-related metabolites that were associated with physiologic HFpEF, including prostaglandin, linoleic acid, and epoxide derivatives. Among these, 18 were associated with future development of heart failure in the community. Further, eicosanoid profiles highlighted contributions to exercise intolerance. Specific eicosanoid and eicosanoid-related metabolites may contribute to the pathogenesis of HFpEF and may serve as potential therapeutic targets for intervention.
Shifts in maize microbial communities and networks are correlated with the soil soil chemical property under different fertilization regimes
Authors: Ji Lidong , Xu Xing , Zhang Fengju , Si Haili , Li Lei , Mao Guilian 
Published: January 2023

Abstract
Purpose: Substituting chemical fertilizer with organic fertilizer is an important agricultural practice that improves crop yield but also affects soil biogeochemical cycles.
Methods: In this study, a corn field experiment was conducted to investigate the effects of NPK fertilizer (NPK), organic fertilizer (OF) or their combination (NPK+OF) on soil chemical properties, bacterial and fungal community structures and diversity using high-throughput sequencing technology.
Result: Results showed the application of organic fertilizer and NPK combined organic fertilizer increased OM, TN, TP, AN, AP and AK level. Combined with α-diversity analysis, the application of fertilizers led to a decrease in soil bacterial and fungal diversity. Compared with CK, NPK, OF or NPK+OF significantly increased abundance of dominant bacteria (Acidobacteriota, and Gemmatimonadota) and fungi(Basidiomycota). Bacterial and fungal community composition and structure were different among all four treatments. Network analysis showed that fertilization produced fewer connections among bacterial and fungal taxa in the microbial community, especially in the combination of NPK and organic fertilizer. Redundancy analysis combined with Mantel test further found that soil organic matter (OM) and available N and P were main environmental factors driving microbial community variation.
Conclusion: Therefore, using organic fertilizer or biological fertilizer combined with chemical fertilizer to improve the status of soil AN, AP and SOC is a promising method to maintain the balance of soil microorganism in continuous cropping single cropping cotton field.
Ferromagnetic (Sb2Te 3)1-x (MnSb2Te4)x Structures with High Curie Temperature Grown by Molecular Beam Epitaxy
Authors: Levy Ido , Forrester Candice , Ding Xiaxin , Testelin Christophe , Krusin-Elbaum Lia , Tamargo Maria C. 
Published: January 2023

Abstract
Magnetic topological materials are promising for realizing novel quantum physical phenomena. Among these, bulk Mn-rich MnSb2Te4 is ferromagnetic due to MnSb antisites and has relatively high Curie temperatures (TC), which is attractive for technological applications. We have previously reported the growth of materials with the formula (Sb2Te3)1−x(MnSb2Te4)x. Here we report their magnetic and transport properties. We show that the samples are divided into three groups based on the percent septuple layers (SLs) within the crystals and their corresponding TC values. Samples that contain less than 70% or more than 90% SLs have a single TC value of 15-20K and 30-40K, respectively, while samples with between 70–80% SLs exhibit two TC values, one at ~ 30-40K and the second (TC2) reaching values above 80K, almost twice as high as any reported value to date for these type of materials. Structural analysis shows that samples with 70–80% SLs have large regions of only SLs, which should give rise to a TC of ~ 30-40K, while other regions have isolated QLs embedded within the SL lattice. We propose that the latter regions are responsible for the higher TC2 values. Our results have important implications for the design of magnetic topological materials having optimum properties.
High-performance broadband flexible photodetector based on Gd3Fe5O12-assisted double van der Waals heterojunctions
Authors: Yang Shuming , Zhang Ze , Ji Peirui , Li Shaobo , Wang Fei , He Shengmei , Cheng Yiwei , Zhao Shuhao , Li Kaili , Wang Xiaomin , Wang Yu 
Published: January 2023

Abstract
Flexible photodetectors are fundamental elements to develop wearable systems, which can be widely used for in medical detection, environmental monitoring and flexible imaging, etc. However, compared with 3D materials, the degraded performance based on low dimensional materials remains a key challenge for current flexible photodetectors. Here, a broadband photoresponse flexible photodetector with high performance has been proposed and fabricated. By combining the high mobility of graphene (Gr) with the strong light–matter interactions of single-walled carbon nanotubes (SWCNT) and molybdenum disulfide (MoS2), the flexible photodetector exhibits a greatly improved photoresponse performance covering visible to near-infrared range. Additionally, the thin layer of gadolinium iron garnet (Gd3Fe5O12, GdlG) films are introduced to improve the interface of the double van der Waals heterojunctions to reduce the dark current. The SWCNT/GdIG/Gr/GdIG/MoS2 flexible photodetector exhibits a high photoresponsivity of 47.375 A/W and a high detectivity of 1.952×1012 Jones at 450nm, 109.311 A/W and a high detectivity of 4.504×1012 Jones at 1080nm, with good mechanical stability at room temperature. This work demonstrates the good capacity of GdIG-assisted double van der Waals heterojunctions on flexible substrates and provides a new solution for preparing high-performance flexible photodetectors.
Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c
Authors: Dimond Andrew , de Pette Mathew Van , Taylor-Bateman Victoria , Brown Karen , Sardini Alessandro , Whilding Chad , Feytout Amelie , Prinjha Rabinder K. , Merkenschlager Matthias , Fisher Amanda G. 
Published: January 2023

Abstract
Genomic imprinting is an epigenetically mediated mechanism that regulates allelic expression of genes based upon parent-of-origin and provides a paradigm for studying epigenetic silencing and release. Here, bioluminescent reporters for the maternally-expressed imprinted gene Cdkn1c are used to examine the capacity of chromatin-modifying drugs to reverse paternal Cdkn1c silencing. Exposure of reporter mouse embryonic stem cells (mESCs) to 5-Azacytidine, HDAC inhibitors, BET inhibitors or GSK-J4 (KDM6A/B inhibitor) relieved repression of paternal Cdkn1c, either selectively or by inducing biallelic effects. Treatment of reporter fibroblasts with HDAC inhibitors or GSK-J4 resulted in similar paternal Cdkn1c activation, whereas BET inhibitor-induced loss of imprinting was specific to mESCs. Changes in allelic expression were generally not sustained in dividing cultures upon drug removal, indicating that the underlying epigenetic memory of silencing was maintained. In contrast, Cdkn1c de-repression by GSK-J4 was retained in both mESCs and fibroblasts following inhibitor removal, although this impact may be linked to cellular stress and DNA damage. Taken together, these data introduce bioluminescent reporter cells as tools for studying epigenetic silencing and disruption, and demonstrate that Cdkn1c imprinting requires distinct and cell-type specific chromatin features and modifying enzymes to enact and propagate a memory of silencing.
Relationship between C-reactive protein and stages of Chronic Obstructive Pulmonary Disease; A cross-sectional study
Authors: Prakash Ashwini , Satish Vikyath , R Vedavathi 
Published: January 2023

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that obstructs airflow. Here, we evaluate the relationship between C-reactive protein (CRP) levels and the stages of COPD.
Methods
A cross-sectional study involving 60 patients diagnosed with COPD aged between 35 to 70 years was performed and the relationship between CRP and stages of COPD was noted. Data was tabulated and analyzed using Analysis of Variance (ANOVA) and a p-value of < 0.05 was considered significant.
Results
Fifty percent of the study participants were aged between 51 to 60 years with a mean of 55.85 ± 7.64 years. According to the Global Initiative for Lung Disease (GOLD) criteria, 50 percent of the study participants were diagnosed with Stage II COPD and 35% with Stage III COPD. The mean forced expiratory volume in one second (FEV1) was 84 ± 2.39 percent in stage I COPD and 28.20 ± 1.48 percent in stage IV. The mean CRP levels recorded were 3.91 ± 1.26 mg/dL in stage I COPD (p < 0.05), 5.79 ± 1.23 mg/dL in stage II (p < 0.05), 9.01 ± 0.96 mg/dL in stage III (p < 0.05) and 11.98 ± 0.73 stage IV (p < 0.05). Statistically significant incremental mean CRP level was noted with progressive stages of COPD.
Conclusions
COPD is a systemic inflammatory disease in which CRP levels significantly increase with the progression of the disease. This warrants serial measurement of CRP in patients with COPD to monitor the progression of the disease. Measurement of CRP should also be considered in stable COPD patients to document the baseline for follow-up.
A Non-destructive Method to Predict the Compressive Strength of Building Materials
Authors: Kayabali Kamil , Beyaz Turgay , Ozdemir Ilknur Karaaslan , Yilmaz Deniz 
Published: January 2023

Abstract
Laboratory tests used to determine the compressive strength (CS) of building materials are both time-consuming and relatively costly. Numerous alternative methods have been developed for the indirect determination of CS. One of them is the nail gun. The driving energies of commercially available nail guns are generally constant, and nailers of different energies need to be used for materials with varying levels of compressive strengths. The scope of this investigation is to indirectly predict the compressive strength of most common building materials by establishing an empirical relationship between nail penetration resistance and CS by employing a single and simple tool. In the research, rocks, bricks, and concretes prepared in different cement/sand ratios with different strength ranges were used as materials. The compressive strength of the materials used in the experiments was first determined by conventional compression tests. The nail penetration depths were determined by conducting experiments on the same materials using a nailer with two different energy levels. An empirical relationship was developed by using nail penetration depths, driving energies, and nail diameters as the independent variables and the compressive strength determined by the conventional method as the dependent variable. According to the empirical relationship determined by multiple regression analysis, the compressive strength of building materials can be estimated with 89% accuracy by the nail penetration method.
Perception of a group of portuguese nurses on women̕ s the contraceptive decisión-making after abortion
Authors: palma sara , presado helena , ayres-de-campos diogo 
Published: January 2023

Abstract

Background: Half of the pregnancies worldwide are unplanned and are related to failures, non-use, incorrect use and/or discontinued contraceptive methods. Nurses are essential health promotion agents, which includes contraceptive counselling, which promotes decision-making regarding the most appropriate contraceptive method. We want to understand midwives' perceptions of the aspects that promote decision-making for a contraceptive method by women in the process of termination of pregnancy.
Methods: Descriptive study method with a qualitative approach using a focus group interview. Five midwives participated in the termination of pregnancy consultation at a hospital in Lisbon, and Vale do Tejo in Portugal, in August 2020. We carried out a content analysis of the participants' speeches with the help of the methodology advocated by Bardin and the use of the WebQdA® software.
Main Results: Midwives point to sociocultural and economic aspects, age and lack of literacy as conditioning factors in choosing a contraceptive method.
Conclusions: Understanding the factors that drive women's contraceptive choices can promote interventions that promote sexual and reproductive health.