bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroprevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antibodies among healthcare personnel in the Midwestern United States, September 2020–April 2021
Authors: Bosserman Rachel E. , Farnsworth Christopher W. , O’Neil Caroline A. , Cass Candice , Park Daniel , Ballman Claire , Wallace Meghan A. , Struttmann Emily , Stewart Henry , Arter Olivia , Peacock Kate , Fraser Victoria J. , Budge Philip J. , Olsen Margaret A. , Burnham Carey-Ann D. , Babcock Hilary M. , Kwon Jennie H. ,   for the CDC Prevention Epicenters
Published: August 2023

Abstract

Objective:
To determine the prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG nucleocapsid (N) antibodies among healthcare personnel (HCP) with no prior history of COVID-19 and to identify factors associated with seropositivity.

Design:
Prospective cohort study.

Setting:
An academic, tertiary-care hospital in St. Louis, Missouri.

Participants:
The study included 400 HCP aged ≥18 years who potentially worked with coronavirus disease 2019 (COVID-19) patients and had no known history of COVID-19; 309 of these HCP also completed a follow-up visit 70–160 days after enrollment. Enrollment visits took place between September and December 2020. Follow-up visits took place between December 2020 and April 2021.

Methods:
At each study visit, participants underwent SARS-CoV-2 IgG N-antibody testing using the Abbott SARS-CoV-2 IgG assay and completed a survey providing information about demographics, job characteristics, comorbidities, symptoms, and potential SARS-CoV-2 exposures.

Results:
Participants were predominately women (64%) and white (79%), with median age of 34.5 years (interquartile range [IQR], 30–45). Among the 400 HCP, 18 (4.5%) were seropositive for IgG N-antibodies at enrollment. Also, 34 (11.0%) of 309 were seropositive at follow-up. HCP who reported having a household contact with COVID-19 had greater likelihood of seropositivity at both enrollment and at follow-up.

Conclusions:
In this cohort of HCP during the first wave of the COVID-19 pandemic, ∼1 in 20 had serological evidence of prior, undocumented SARS-CoV-2 infection at enrollment. Having a household contact with COVID-19 was associated with seropositivity.
On the dimension of stationary measures for random piecewise affine interval homeomorphisms
Authors: BARAŃSKI KRZYSZTOF , ŚPIEWAK ADAM 
Published: August 2023

AbstractWe study stationary measures for iterated function systems (considered as random dynamical systems) consisting of two piecewise affine interval homeomorphisms, called Alsedà–Misiurewicz (AM) systems. We prove that for an open set of parameters, the unique non-atomic stationary measure for an AM system has Hausdorff dimension strictly smaller than
$1$
. In particular, we obtain singularity of these measures, answering partially a question of Alsedà and Misiurewicz [Random interval homeomorphisms. Publ. Mat.58(suppl.) (2014), 15–36].
A qualitative evaluation of a telehealth healthy lifestyle intervention for people with serious mental illness
Authors: O’Keeffe D. , Clarke M. 
Published: August 2023

AbstractObjectives:There are high levels of nutritional and metabolic, cardiovascular, and respiratory tract diseases among people diagnosed with serious mental illness (SMI). Consequently, we developed a pragmatic, affordable nutritional and exercise intervention: Choices4Health. Due to the COVID-19 pandemic, we modified this intervention so it could be delivered online. The aim of this study was to explore the experience of participating in online Choices4Health, in a real-world clinical setting, from the perspectives of service users with SMI.Methods:The study aim was addressed using thematic analysis. Service users who had attended online Choices4Health, received a SMI diagnosis (defined as a schizophrenia spectrum disorder or an affective disorder), and resided in a South Dublin catchment were invited to participate. Nine participants were purposefully sampled. Semi-structured interviews were conducted by telephone. Data analysis was guided by thematic analysis procedures.Results:Six themes were generated: Being ready and not overburdened (Engagement); Gaining knowledge and implementing it (Learning and doing); Viewing the intervention as appropriate and effective (Targeted impact); Being at home with others online (Belonging); Having a positive affective attitude towards the intervention (Feeling); and Perceiving problems with intervention delivery (Recommended change).Conclusions:Findings suggest that online Choices4Health is, broadly speaking, acceptable from a service user perspective, but that further refinement is required to address specific issues participants identified. These relate to follow-up or programme extension, technology access, in-person contact preference, and participant inclusion criteria. Further research is required into online Choices4Health efficacy, innovations to reduce digital exclusion, and managing group dynamics in telehealth interventions.
The choice of musical instrument matters: Effect of pitched but not unpitched musicianship on tone identification and word learning
Authors: Choi William , To Cheuk Yiu , Cheng Runqing 
Published: August 2023

AbstractThe present study investigated the differential effects of pitched and unpitched musicianship on tone identification and word learning. We recruited 44 Cantonese-pitched musicians, unpitched musicians, and non-musicians. They completed a Thai tone identification task and seven sessions of Thai tone word learning. In the tone identification task, the pitched musicians outperformed the non-musicians but the unpitched musicians did not. In session 1 of the tone word learning task, the three groups showed similar accuracies. In session 7, the pitched musicians outperformed the non-musicians but the unpitched musicians did not. The results indicate that the musical advantage in tone identification and word learning hinges on pitched musicianship. From a theoretical perspective, these findings support the precision element of the OPERA hypothesis. Broadly, they reflect the need to consider the heterogeneity of musicianship when studying music-to-language transfer. Practically, the findings highlight the potential of pitched music training in enhancing tone word learning proficiency. Furthermore, the choice of musical instrument may matter to music-to-language transfer.
German-dominant Vietnamese heritage speakers use semantic constraints of German for anticipation during comprehension in Vietnamese
Authors: Ito Aine , Nguyen Huong Thi Thu , Knoeferle Pia 
Published: August 2023

AbstractTo test effects of German on anticipation in Vietnamese, we recorded eye-movements during comprehension and manipulated i) verb constraints (different vs. similar in German and Vietnamese) and ii) classifier constraints (absent in German). In each of two experiments, participants listened to Vietnamese sentences like “Mai mặc một chiếc áo.” (‘Mai wears a [classifier] shirt.’), while viewing four objects. Between experiments, we contrasted bilingual background: L1 Vietnamese–L2 German late bilinguals (Experiment 1) and heritage speakers of Vietnamese in Germany (Experiment 2). Both groups anticipated verb-compatible and classifier-compatible objects upon hearing the verb/classifier. However, when the (verb) constraints differed (e.g., Vietnamese: mặc ‘wear (a shirt/#earrings)’ – German: tragen ‘wear (a shirt/earrings)’), the heritage speakers were distracted by the object (earrings) compatible with the German (but not the Vietnamese) verb constraints. These results demonstrate that competing information in the two languages can interfere with anticipation in heritage speakers.
Strong Warming Over the Antarctic Peninsula During Combined Atmospheric River and Foehn Events: Contribution of Shortwave Radiation and Turbulence
Authors: Zou Xun , Rowe Penny M. , Gorodetskaya Irina , Bromwich David H. , Lazzara Matthew A. , Cordero Raul R. , Zhang Zhenhai , Kawzenuk Brian , Cordeira Jason M. , Wille Jonathan D. , Ralph F. Martin , Bai Le‐Sheng 
Published: August 2023

AbstractThe Antarctica Peninsula (AP) has experienced more frequent and intense surface melting recently, jeopardizing the stability of ice shelves and ultimately leading to ice loss. Among the key phenomena that can initiate surface melting are atmospheric rivers (ARs) and leeside foehn; the combined impact of ARs and foehn led to moderate surface warming over the AP in December 2018 and record‐breaking surface melting in February 2022. Focusing on the more intense 2022 case, this study uses high‐resolution Polar WRF simulations with advanced model configurations, Reference Elevation Model of Antarctica topography, and observed surface albedo to better understand the relationship between ARs and foehn and their impacts on surface warming. With an intense AR (AR3) intrusion during the 2022 event, weak low‐level blocking and heavy orographic precipitation on the upwind side resulted in latent heat release, which led to a more deep‐foehn like case. On the leeside, sensible heat flux associated with the foehn magnitude was the major driver during the night and the secondary contributor during the day due to a stationary orographic gravity wave. Downward shortwave radiation was enhanced via cloud clearance and dominated surface melting during the daytime, especially after the peak of the AR/foehn events. However, due to the complex terrain of the AP, ARs can complicate the foehn event by transporting extra moisture to the leeside via gap flows. During the peak of the 2022 foehn warming, cloud formation on the leeside hampered the downward shortwave radiation and slightly increased the downward longwave radiation.
Beyond the Case Study: Characterizing Natural Floodplain Heterogeneity in the United States
Authors: Iskin Emily P. , Wohl Ellen 
Published: August 2023

AbstractWe use the five landscape ecology metrics of aggregation index, percentage of like adjacencies, interspersion and juxtaposition index, patch density, and Shannon's evenness index to assess spatial heterogeneity at 15 floodplains in the continental United States. Assessments are based on floodplain classes and patches delineated remotely using topography and vegetation. Floodplain reaches examined here represent diverse drainage areas, flow regimes, valley geometries, channel planforms, and biomes. We selected sites with minimal direct human alteration. Our objectives are to quantify floodplain spatial heterogeneity; evaluate whether statistically significant patterns are present; and interpret the statistical analyses with respect to the influence of lateral channel mobility and valley‐floor space available. We develop a conceptual model of the influences on lateral mobility and space available, and then test specific hypotheses derived from this conceptual model. These natural floodplains have a median aggregation index of 58.8%, median percentage of like adjacencies of 58.5%, median interspersion and juxtaposition index of 74.9%, median density of 1,241 patches/ha, and median Shannon's evenness index of 0.934 (n = 15). In other words, natural floodplains have moderate aggregation of classes, high evenness and intermixing of classes, and a wide range of patch densities. Drainage area, the ratio of floodplain/channel width, elevation, precipitation, total sinuosity, large wood volume, planform, and flow regime emerge as important variables to floodplain heterogeneity. These results highlight the influence of biotic‐abiotic interactions in shaping floodplain heterogeneity across diverse river corridors.
Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma
Authors: Xie Hong , Shih Chia-Hao , Aldoohan Sulaiman D. , Wall John T. , Wang Xin 
Published: August 2023

AbstractThe hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience (ACE) can affect brain structure, which may contribute to development of posttraumatic stress disorder (PTSD) after subsequent adult trauma. It is unclear, however, if ACE history is particularly associated with aspects of hypothalamic structure which contribute to development of PTSD. To address this issue, the present study longitudinally assessed hypothalamic volumes and their associations with ACE and early post-trauma stress symptoms in subjects who did or did not develop PTSD during 12 months after adult trauma. 109 subjects (18–60 years, F/M = 75/34) completed the PTSD Checklist (PCL) questionnaire for post-trauma stress symptoms, the Childhood Trauma Questionnaire (CTQ) for ACE assessment, and an initial MRI brain scan for hypothalamic volume measurement, within 2 weeks after adult trauma. At post-trauma 12 months, subjects underwent a subsequent PTSD diagnosis interview using the Clinician-Administered PTSD Scale (CAPS), and a follow-up MRI scan. Left and right hypothalamus volumes at 2 weeks after adult trauma negatively correlated with CTQ scores. Right hypothalamus volume at this early time mediated an association between ACE and PTSD symptoms 12 months later. Right hypothalamus volumes also remained persistently smaller from 2 weeks to 12 months after trauma in survivors who developed PTSD. These results suggest that smaller right hypothalamus volume may be related to ACE history in ways that contribute to PTSD development after trauma in adulthood.
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
Authors: Van San Emily , Debruyne Angela C. , Veeckmans Geraldine , Tyurina Yulia Y. , Tyurin Vladimir A. , Zheng Hao , Choi Sze Men , Augustyns Koen , van Loo Geert , Michalke Bernhard , Venkataramani Vivek , Toyokuni Shinya , Bayir Hülya , Vandenabeele Peter , Hassannia Behrouz , Vanden Berghe Tom 
Published: August 2023

AbstractMultiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous (CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is driven by an auto-amplifying mechanism of inflammation and cell death. Current therapies mainly focus on disease modification by immunosuppression, while no treatment specifically focuses on controlling cell death injury. Here, we report that ferroptosis, an iron-catalyzed mode of regulated cell death (RCD), contributes to MS disease progression. Active and chronic MS lesions and cerebrospinal fluid (CSF) of MS patients revealed several signs of ferroptosis, reflected by the presence of elevated levels of (labile) iron, peroxidized phospholipids and lipid degradation products. Treatment with our candidate lead ferroptosis inhibitor, UAMC-3203, strongly delays relapse and ameliorates disease progression in a preclinical model of relapsing-remitting MS. In conclusion, the results identify ferroptosis as a detrimental and targetable factor in MS. These findings create novel treatment options for MS patients, along with current immunosuppressive strategies.
The first linkage map for Australo-Papuan Treefrogs (family: Pelodryadidae) reveals the sex-determination system of the Green-eyed Treefrog (Litoria serrata)
Authors: Bertola Lorenzo V. , Hoskin Conrad J. , Jones David B. , Zenger Kyall R. , McKnight Donald T. , Higgie Megan 
Published: August 2023

AbstractAmphibians represent a useful taxon to study the evolution of sex determination because of their highly variable sex-determination systems. However, the sex-determination system for many amphibian families remains unknown, in part because of a lack of genomic resources. Here, using an F1 family of Green-eyed Treefrogs (Litoria serrata), we produce the first genetic linkage map for any Australo-Papuan Treefrogs (family: Pelodryadidae). The resulting linkage map contains 8662 SNPs across 13 linkage groups. Using an independent set of sexed adults, we identify a small region in linkage group 6 matching an XY sex-determination system. These results suggestLitoria serratapossesses a male heterogametic system, with a candidate sex-determination locus on linkage group 6. Furthermore, this linkage map represents the first genomic resource for Australo-Papuan Treefrogs, an ecologically diverse family of over 220 species.
Long-range, non-local switching of spin textures in a frustrated antiferromagnet
Authors: Haley Shannon C. , Maniv Eran , Wu Shan , Cookmeyer Tessa , Torres-Londono Susana , Aravinth Meera , Maksimovic Nikola , Moore Joel , Birgeneau Robert J. , Analytis James G. 
Published: August 2023

AbstractAntiferromagnetic spintronics is an emerging area of quantum technologies that leverage the coupling between spin and orbital degrees of freedom in exotic materials. Spin-orbit interactions allow spin or angular momentum to be injected via electrical stimuli to manipulate the spin texture of a material, enabling the storage of information and energy. In general, the physical process is intrinsically local: spin is carried by an electrical current, imparted into the magnetic system, and the spin texture will then rotate in the region of current flow. In this study, we show that spin information can be transported and stored “non-locally" in the material FexNbS2. We propose that collective modes can manipulate the spin texture away from the flowing current, an effect amplified by strong magnetoelastic coupling of the ordered state. This suggests a novel way to store and transport spin information in strongly spin-orbit coupled magnetic systems.
Ultrahigh-efficient material informatics inverse design of thermal metamaterials for visible-infrared-compatible camouflage
Authors: Xi Wang , Lee Yun-Jo , Yu Shilv , Chen Zihe , Shiomi Junichiro , Kim Sun-Kyung , Hu Run 
Published: August 2023

AbstractMultispectral camouflage technologies, especially in the most frequently-used visible and infrared (VIS-IR) bands, are in increasing demand for the ever-growing multispectral detection technologies. Nevertheless, the efficient design of proper materials and structures for VIS-IR camouflage is still challenging because of the stringent requirement for selective spectra in a large VIS-IR wavelength range and the increasing demand for flexible color and infrared signal adaptivity. Here, a material-informatics-based inverse design framework is proposed to efficiently design multilayer germanium (Ge) and zinc sulfide (ZnS) metamaterials by evaluating only ~1% of the total candidates. The designed metamaterials exhibit excellent color matching and infrared camouflage performance from different observation angles and temperatures through both simulations and infrared experiments. The present material informatics inverse design framework is highly efficient and can be applied to other multi-objective optimization problems beyond multispectral camouflage.
The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis
Authors: Zhao Ziyu , Vercellino Irene , Knoppová Jana , Sobotka Roman , Murray James W. , Nixon Peter J. , Sazanov Leonid A. , Komenda Josef 
Published: August 2023

AbstractRobust oxygenic photosynthesis requires a suite of accessory factors to ensure efficient assembly and repair of the oxygen-evolving photosystem two (PSII) complex. The highly conserved Ycf48 assembly factor binds to the newly synthesized D1 reaction center polypeptide and promotes the initial steps of PSII assembly, but its binding site is unclear. Here we use cryo-electron microscopy to determine the structure of a cyanobacterial PSII D1/D2 reaction center assembly complex with Ycf48 attached. Ycf48, a 7-bladed beta propeller, binds to the amino-acid residues of D1 that ultimately ligate the water-oxidising Mn4CaO5 cluster, thereby preventing the premature binding of Mn2+ and Ca2+ ions and protecting the site from damage. Interactions with D2 help explain how Ycf48 promotes assembly of the D1/D2 complex. Overall, our work provides valuable insights into the early stages of PSII assembly and the structural changes that create the binding site for the Mn4CaO5 cluster.
Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia
Authors: Hu Jiadong , Qiu Shi , Wang Feiyan , Li Qing , Xiang Chun-Lei , Di Peng , Wu Ziding , Jiang Rui , Li Jinxing , Zeng Zhen , Wang Jing , Wang Xingxing , Zhang Yuchen , Fang Shiyuan , Qiao Yuqi , Ding Jie , Jiang Yun , Xu Zhichao , Chen Junfeng , Chen Wansheng 
Published: August 2023

AbstractThe genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages. To elucidate how ATD chemical diversity evolved, we carried out large-scale metabolic and phylogenetic analyses of 71 Salvia species, combined with enzyme function, ancestral sequence and chemical trait reconstruction, and comparative genomics experiments. This integrated approach showed that the lineage-wide ATD diversities in Salvia were induced by differences in the oxidation of the terpenoid skeleton at C-20, which was caused by the functional divergence of the cytochrome P450 subfamily CYP76AK. These findings present a unique pattern of chemical diversity in plants that was shaped by the loss of enzyme activity and associated catalytic pathways.
XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis
Authors: Chen Ying-Lan , Lin Fan-Wei , Cheng Kai-Tan , Chang Chi-Hsin , Hung Sheng-Chi , Efferth Thomas , Chen Yet-Ran 
Published: August 2023

AbstractProteolytic activation of cytokines regulates immunity in diverse organisms. In animals, cysteine-dependent aspartate-specific proteases (caspases) play central roles in cytokine maturation. Although the proteolytic production of peptide cytokines is also essential for plant immunity, evidence for cysteine-dependent aspartate-specific proteases in regulating plant immunity is still limited. In this study, we found that the C-terminal proteolytic processing of a caspase-like substrate motif “CNYD” within Pathogenesis-related protein 1 (PR1) generates an immunomodulatory cytokine (CAPE9) in Arabidopsis. Salicylic acid enhances CNYD-targeted protease activity and the proteolytic release of CAPE9 from PR1 in Arabidopsis. This process involves a protease exhibiting caspase-like enzyme activity, identified as Xylem cysteine peptidase 1 (XCP1). XCP1 exhibits a calcium-modulated pH-activity profile and a comparable activity to human caspases. XCP1 is required to induce systemic immunity triggered by pathogen-associated molecular patterns. This work reveals XCP1 as a key protease for plant immunity, which produces the cytokine CAPE9 from the canonical salicylic acid signaling marker PR1 to activate systemic immunity.
Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides
Authors: Wang Bo-Ran , Li Yan-Bo , Zhang Qi , Gao Dingding , Tian Ping , Li Qinghua , Yin Liang 
Published: August 2023

AbstractHerein, we report a copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and 1,3-enynes, which provides a series of chiral poly-substituted pyrrolidines in high regio-, diastereo-, and enantioselectivities. Both 4-aryl-1,3-enynes and 4-silyl-1,3-enynes serve as suitable dipolarophiles while 4-alkyl-1,3-enynes are inert. Moreover, the method is successfully applied in the construction of both tetrasubstituted stereogenic carbon centers and chiral spiro pyrrolidines. The DFT calculations are also conducted, which imply a concerted mechanism rather than a stepwise mechanism. Finally, various transformations started from the pyrrolidine bearing a triethylsilylethynyl group and centered on the alkyne group are achieved, which compensates for the inertness of 4-alkyl-1,3-enynes in the present reaction.