bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to Hearing Healthcare and Barriers Among United States Veterans: A Survey‐Based Study
Authors: Gallagher Tyler J. , Hori Kaitlin , Choi Janet S. 
Published: January 2025

AbstractObjectiveWe investigated use of hearing care among US veterans and explore motivations, barriers, and adherence to hearing healthcare.Study DesignCross‐sectional online survey.SettingUS Veterans.MethodsThis cross‐sectional, online survey‐based study included 287 respondents who identified themselves as veterans on ResearchMatch (NIH‐sponsored national registry of research volunteers). Questions regarding hearing loss, tinnitus, use of hearing care, and facilitators/barriers to hearing care were asked. Descriptive statistics were utilized for data analysis.ResultsIn this cohort, the rate of self‐reported hearing loss and tinnitus were 61.0% and 74.2%, respectively. Among these, 66.9% of those with hearing loss and 36.2% of those with tinnitus reported seeking hearing care. Most important motivators of seeking hearing care (average on 1‐5 Likert scale) included personal importance of hearing (4.0; SD = 1.1), difficulty hearing others (3.6; SD = 1.1), and degree of hearing loss (3.3; SD = 1.1). Most common barriers included uncertainty regarding who to reach out to for hearing care (42.9%), inability to get time off work (34.3%), and nervousness about seeing a provider (28.6%). Common reasons to decline hearing aids reporting that hearing was not bad enough for hearing aids (72.2%) and included inability to afford hearing aid (55.6%).ConclusionIn this cohort, many US veterans sought care for hearing loss, though barriers still exist, including uncertainty regarding how to access appropriate care, being too far from a provider, and challenges with cost. Future studies should investigate methods to alleviate these internal and external barriers to hearing care and emphasize the importance of motivators for seeking care.
Removal of Heavy Metal Ions on Lead Ion‐Imprinted Modified Polyurethane Wet‐Spun Fibers
Authors: Wu Jun , Wu Xiao , Yin Maoli , Yang Yunlai , Yao Yinqi , Liu Xinhua , Li Xiaojuan 
Published: January 2025

ABSTRACTThe molecular imprinted polymers are prepared by molecular imprinting technique with specific selectivity in target substances. To prepare high performance and specific lead ion adsorbent, hence, chitosan was used to blend polyurethane; the modified fiber was a matrix for initiating graft polymerization of acrylic acid on surface. Lead ion imprinted fibers were prepared by lead‐ion as template and epichlorohydrin in crosslinking agent. The influence of graft rate and adsorption properties of imprinted materials for lead‐ions was analyzed. The result suggests that the maximum graft rate of acrylic acid is 59.10%; hydrophilicity and stability of grafted fiber membranes are significantly improved. Furthermore, the saturated adsorption capacity of lead ion imprinted fibers reaches the maximum under 20°C nearly neutral. The relative selection coefficients of lead ion for cupric ion and cadmium ion were 2.72 and 6.06, respectively. This indicates that the imprinted fibers show specific selectivity for lead ion used for a potential adsorbent in removing heavy metal ions.
Renovating nanocomposite design: A novel conductivity model for polymer graphene systems incorporating interphase and tunneling zones
Authors: Vatani Mostafa , Zare Yasser , Munir Muhammad Tajammal , Rhee Kyong Yop 
Published: January 2025

AbstractMany papers have studied the electrical conductivity of graphene‐filled nanocomposites, but the roles of imperfect interphase in the percolation onset and nanocomposite conductivity were ignored. In this manuscript, two interface parameters including the minimum graphene diameter to transfer its conductivity to the polymer medium (Dc) and interface conduction (ѱ) are defined in polymer composites by graphene size and interphase deepness. Then, the actual converse aspect ratio, real filler portion, and percolation inception are given by graphene size and interphase deepness. Also, a model is developed based on the stated terms for conductivity of graphene‐containing composites. The impacts of various parameters on the “Dc,” “ѱ,” actual filler portion, percolation inception, and nanocomposite conductivity are plotted and justified by new equations. Moreover, the forecasts of conductivity and percolation inception are associated to several experimented data. Narrow nanosheets and thick interphase positively govern the “Dc,” interface conduction, actual filler portion, the inception of percolation, and conductivity of system. The maximum interface conduction as 1400 S/m is reached by graphene thickness (t) of 2 nm and interphase depth (ti) of 6 nm, but the interface conduction largely reduces to 100 S/m at ti <2.7 nm. These results recommend that reedy nanosheets and bushy interphase cause a high interface conduction in nanocomposites. Furthermore, high nanosheet diameter (D) negatively affects “Dc” and interface conduction, but it produces the low percolation inception and high conductivity. The nanocomposite conductivity reaches 0.9 S/m at D = 5 μm and graphene conductivity of 2 × 105 S/m.Highlights
A conventional model is developed for conductivity of graphene‐containing composites.
Two interfacial parameters as “Dc” and “ѱ” are considered in the nanocomposites.
The forecasts of conductivity are compared to the experimented data of several samples.
Narrow nanosheets and thick interphase positively govern the “Dc” and conductivity.
Bigger nanosheets negatively affect the “Dc”, but produce a higher composite conductivity.
Thermal Responses and Cell Adhesive Properties of Glycosylated Jigsaw‐Shaped Self‐Assembling Peptides
Authors: Hara Yoshika , Yoshizawa Ken , Uchida Noriyuki , Muraoka Takahiro 
Published: January 2025

ABSTRACTAs represented by the posttranslational modifications of proteins, the chemical modifications of side chains of peptide residues enable to regulate their physicochemical properties, conformation, and biological activities. Glycosylation is a main post‐translational modification, which allows for recognition by partner proteins to exert diverse function including increase in the conformational stability. Here, we studied the effects of glucose modification, which is a representative glycosylation sugar chains, to different positions of an amphiphilic peptide having a jigsaw‐shaped hydrophobic part (JigSAP). JigSAP forms a β‐sheet structure to self‐assemble into fibrous objects providing a hydrogel that can be used as a matrix for regenerative medicine. JigSAPs modified with glucose at the N‐terminus and middle portion were synthesized, and both of them self‐assemble in water to form hydrogels. The hydrogel composed of JigSAP containing the glucose group attached to the N‐terminus undergoes a gel‐to‐sol macroscopic phase transition upon heating, accompanied by a conformational change of JigSAP from the β‐sheet to an α‐helix structure. On the other hand, JigSAP with the glucose group in the middle, retained its β‐sheet structure even at high temperatures maintaining the gel state. Both glucose‐modified JigSAP fibers showed cell adhesion activity similar to that of non‐glycosylated JigSAP. This suggests that the glycosylation is effective in regulating the thermal stability of JigSAP fibers while maintaining their extracellular matrix properties depending on the modification site.
Exploring the Conformational Space of MPS1 Kinase Using Metadynamics
Authors: Singh Anuradha , Lakkaniga Naga Rajiv 
Published: January 2025

ABSTRACTMPS1 kinase is a dual specificity kinase that plays an important role in the spindle assembly checkpoint mechanism during cell division. Overexpression of MPS1 kinase is reported in several cancers. However, drug discovery and development efforts targeting MPS1 kinase did not result in any clinically successful candidates. All the reported crystal structures of MPS1 kinase adopt the DFG “in” conformation. Knowledge of the other conformations of the kinase would be beneficial in the structure‐based drug design of novel inhibitors. This work employs well‐tempered metadynamics simulations to explore the conformational space of MPS1 kinase by using its experimentally determined DFG “in” conformation as the starting structure. The simulation could successfully predict the DFG “out” conformation and identify the possible transition states. The key interactions that stabilize the kinase in various conformations were identified, and the effect of phosphorylation of the key residues on the conformation of the kinase was determined.
Mangiferin Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the GAS6/Axl Signaling Pathway
Authors: Zhao Aizhen , Lei Wangrui , Tian Jiayin , Wu Xiaopeng , Li Mengyu , Zhang Yan , Wu Xue , Xu Xuezeng , Tang Jiayou , Yang Yang , Jin Zhenxiao 
Published: January 2025

ABSTRACTIschemia reperfusion‐induced myocardial injury is a prominent pathological feature in patients with coronary artery disease, contributing to significant mortality and morbidity rates. Mangiferin (MGF), the main active ingredient extracted from Anemarrhena asphodeloides Bge, has anti‐inflammatory, anti‐oxidation, anti‐diabetes, and anti‐tumor effects. The present study confirmed that the GAS6/Axl pathway was identified as a promising novel target for the treatment of myocardial ischemia reperfusion (IR) injury. However, whether MGF exerts anti‐myocardial ischemia reperfusion injury through GAS6/Axl is still unclear. In this study, BALB/c male mice and HL‐1 cardiomyocytes were used to construct a model of IR and hypoxia‐reoxygenation (HR) (or H2O2) injury in vivo and in vitro, respectively. MGF significantly improved cardiac function indicators, myocardial structure, myocardial enzymes, and mitochondrial function, together with reduced oxidative stress and apoptosis in IR‐injured mice. In vitro, MGF significantly increased cell viability, inhibited the release of LDH, reduced oxidative stress and apoptosis, and improved mitochondrial function in both HR and H2O2‐injured HL‐1 cells. In particular, the GAS6/Axl signaling pathway plays an important role in this process. Additionally, we also demonstrated that GAS6 gene knockout reversed the protective effect of MGF against HR and H2O2‐injured cardiomyocytes. The present study confirmed that MGF has protective effects against myocardial IR injury by activating the GAS6/Axl pathway, providing a theoretical basis for MGF as a potential cardioprotective drug in the clinical setting of myocardial IR injury.
Template Free Direct Approach to Crystalline Mesoporous ZnO/Bi2O3 Mixed Oxide Nanosheets with Enhanced Photo reactivity
Authors: Latif Saba , Akram Bilal , Khan Bilal Ahmad , Hassan Abeer A. , Nazir Fozia , Alturaifi Huriyyah A. , Musawar Syeda Sundas , Alrafai Halema A. 
Published: January 2025

AbstractThe design and synthesis of mesoporous nanostructured materials have sparked significant interest over the last decade. However, developing a template free approach to obtain transition metal based mixed oxide nanosheets with mesopores is still challenging. We developed an easy template‐free direct solution‐based approach to fabricate crystalline ZnO/Bi2O3 mesoporous nanosheets. The porous features of the mixed oxide nanosheets can be tuned using different precursors of the metal salts. The obtained nanosheets were employed as photocatalyst to treat textile waste using methylene blue (MB) dye as model textile waste. The photocatalyst manifests 92% degradation efficiency. The scavenging experiments indicate that holes are the main reactive species responsible for the degradation of MB. Applying two structurally unique photocatalysts towards dye degradation evidenced the structure activity relationship. This structure‐activity relationship underscores the importance of nanomaterial design and synthesis in optimizing photocatalytic performance for environmental remediation applications.
Deep Red‐Light‐Mediated Nitric Oxide and Photodynamic Synergistic Antibacterial Therapy for the Treatment of Drug‐Resistant Bacterial Infections
Authors: Lin Jingjing , Cao Mingyi , Wang Shiya , Wu Xinyu , Pan Yuhan , Dai Zhiyue , Xu Ningge , Zuo Lumin , Liu Ji , Wang Yuxin , Zhong Qifeng , Xu Yue , Wu Jianbing , Gui Lijuan , Ji Xueying , Liu Heng , Yuan Zhenwei 
Published: January 2025

AbstractInfections caused by persistent, drug‐resistant bacteria pose significant challenges in inflammation treatment, often leading to severe morbidity and mortality. Herein, the photosensitizer rhodamine derivatives are selected as the light‐trapping dye and the electron‐rich substituent N‐nitrosoaminophen as the nitric oxide (NO)‐releasing component to develop a multifunctional (deep) red‐light activatable NO photocage/photodynamic prodrug for efficient treatment of wounds and diabetic foot infections. The prodrug, RhB‐NO‐2 integrates antimicrobial photodynamic therapy (aPDT), NO sterilization, and NO‐mediated anti‐inflammatory properties within a small organic molecule and is capable of releasing NO and generating Reactive oxygen species (ROS) when exposed to (deep) red laser (660 nm). This strategy overcomes the limitation of using a single photosensitizer, which is often inadequate for eliminating drug‐resistant bacteria. Additionally, it demonstrates that NO released from the prodrug can interact with superoxide anions (O2•−) generated by PDT to form a more reactive and oxidative agent, peroxynitrite (ONOO−). These three components act synergistically to enhance the antimicrobial effects. Furthermore, the released NO can inhibit the NF‐κB pathway by regulating the expression of toll‐like receptor 2 (TRL2) and tumor necrosis factor‐α (TNF‐α), thereby alleviating tissue inflammation. The developed prodrug ， RhB‐NO‐2 has the potential to expedite the healing of superficial infected wounds and offer a promising approach for treating diabetic foot ulcers (DFUs).
Analytical solution to the magneto‐elastoplastic problem for functionally graded spherical shells under inner pressure
Authors: Yan Weiwen , Ye Yongqiang , Dong Fei , Zhang Jiansheng , Wang Wenshuai 
Published: January 2025

AbstractAs composite material techniques mature, the study of functionally graded (FG) structures under the multi‐field coupling has become increasingly important. For FG spherical shells, the inhomogeneous distribution of stress fields leads to permanent plastic deformation when external force is applied. In addition, Lorentz force from constant magnetic fields can significantly affect the mechanical properties and mechanical behaviors of functionally graded materials (FGM). In this study, the elastoplastic states of FG spherical shells include four deformations, such as pure elasticity, partial plasticity from the internal or external surface, and complete plasticity. In this paper, elastic modulus and yield criterion of FG spherical shells are hypothesized to follow the power‐law distribution in the thickness direction of spherical shells, and analytical solutions of displacement and stress for various elastoplastic deformation states are proposed, and the critical loads of transition between these various states are determined. By comparing results with the existing work, the correctness of the analytical solutions is verified. In addition, the effects of inner pressure, FG parameter, and external magnetic fields on elastoplastic deformation states and stress, displacement distributions in FG spherical shells are further analysed. The results show that the plastic deformation of FG spherical shells may occur on the internal or external surface subjected to the effect of external magnetic fields and inner pressure. As the FG parameter gradually increases, the first yielding position moves from the internal to the external surface for spherical shells. Further, the external magnetic field has the effect of decreasing the critical inner pressure value that causes FG spherical shells to yield, making the spherical shell more susceptible to plastic deformation.
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Authors: Nöth Julia , Michaelis Paul , Schüler Lennart , Scholz Stefan , Krüger Janet , Haake Volker , Busch Wibke 
Published: January 2025

AbstractTesting for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious and costly and require a large number of vertebrate test animals. To reduce animal numbers and associated costs, the zebrafish embryo was proposed as an alternative model. In this study, we investigated the potential of transcriptome analysis in the zebrafish embryo model to support the identification of potential biomarkers for key events in developmental toxicity, using the inhibition of angiogenesis as a proof of principle. Therefore, the effects on the zebrafish transcriptome after exposure to the tyrosine kinase inhibitors, sorafenib (1.3 µM and 2.4 µM) and SU4312 (1 µM, 2 µM, and 5 µM), and the putative vascular disruptor compound rotenone (25 nM and 50 nM) were analyzed. An early (2 hpf—hours post fertilization) and a late (24 hpf) exposure start with a time resolved transcriptome analysis was performed to compare the specificity and sensitivity of the responses with respect to anti-angiogenesis. We also showed that toxicodynamic responses were related to the course of the internal concentrations. To identify differentially expressed genes (DEGs) the time series data were compared by applying generalized additive models (GAMs). We observed mainly unspecific developmental toxicity in the early exposure scenario, while a specific repression of vascular related genes was only partially observed. In contrast, differential expression of vascular-related genes could be identified clearly in the late exposure scenario. Rotenone did not show angiogenesis-specific response on a transcriptomic level, indicating that the observed mild phenotype of angiogenesis inhibition may represent a secondary effect.
Nearly-circular periodic solutions of perturbed relativistic Kepler problems: the fixed-period and the fixed-energy problems
Authors: Boscaggin Alberto , Feltrin Guglielmo , Papini Duccio 
Published: January 2025

Abstract
The paper studies the existence of periodic solutions of a perturbed relativistic Kepler problem of the type

$$\begin{aligned} \dfrac{\textrm{d}}{\textrm{d}t}\left( \frac{m\dot{x}}{\sqrt{1-|\dot{x}|^{2}/c^{2}}}\right) = -\alpha \frac{x}{|x|^{3}} + \varepsilon \, \nabla _{x} U(t,x), \qquad x \in \mathbb {R}^d\setminus \{0\}, \end{aligned}$$

d

d
t

m

x
˙

1
-
|

x
˙

|

2

/

c
2

=
-
α

x

|
x
|

3

+
ε

∇
x

U

(
t
,
x
)

,

x
∈

R

d

\

{
0
}

,

with

$$d=2$$

d
=
2

or

$$d=3$$

d
=
3

, bifurcating, for

$$\varepsilon $$

ε

small enough, from the set of circular solutions of the unperturbed system. Both the case of the fixed-period problem (assuming that U is T-periodic in time) and the case of the fixed-energy problem (assuming that U is independent of time) are considered.
How does optimal prey abundance shape space use by a territorial raptor?
Authors: Real Joan , Azpillaga Maialen , Bosch Rafel , Hernández-Matías Antonio , Puig-Gironès Roger 
Published: January 2025

Abstract
Understanding predator-prey interactions is important to determine the inter-relationships between species. Optimal foraging theory states that predators balance out energy expended with the energy gained from their prey. In the Iberian Peninsula, the European rabbit (Oryctolagus cuniculus) is a key prey species for endangered Bonelli’s eagle (Aquila fasciata). Thus, it is vital to understand how changes in rabbit abundance can influence habitat selection and territory use by Bonelli’s eagle. We studied 11 radio-tagged Bonelli’s eagles in their territories in Catalonia (NE Iberian Peninsula) and analysed the relationship between rabbit relative abundance, habitat selection and territory use of eagles. Rabbit relative abundance varied between territories, with shrublands hosting more rabbits, and eagles preferred shrublands and open areas for foraging and avoided dense forests. Spatial use by territorial eagles correlated positively with rabbit abundance in rabbit-rich territories, thereby supporting the idea that prey availability influences habitat selection. This result confirms optimal foraging strategies given that open habitats including shrublands tended to host more rabbits, thus providing better opportunities for prey detection and capture. Therefore, maintaining rabbit populations and their habitats (i.e., preserving open Mediterranean shrublands) would seem to be crucial for Bonelli’s eagle conservation. Our findings improve our understanding of predator-prey interactions and highlight the relationship between habitat structure, prey abundance and predator behaviour. In addition, our results emphasize the need for targeted conservation strategies designed to safeguard endangered species such as Bonelli’s eagle and maintain ecosystem integrity.
Sovereignty by design and human values in agriculture data spaces
Authors: Gil Rosa María , Ryan Mark , García Roberto 
Published: January 2025

AbstractBecause of the importance of data-sharing for the economy, improved products and services, and to benefit society, the European Union has proposed developing a Common European Data Space (CEDS). The goal is to create a single European data market through 14 domain-specific data spaces (e.g., agriculture, or the Common European Agricultural Data Space (CEADS)). One of the central tenets of the CEDS is to ensure that those who share data can maintain control over who has access to, use of, and ability to share it (or ‘data sovereignty’). Data sovereignty is an umbrella concept with many different values comprising its implementation. Therefore, to successfully implement data sovereignty in the CEADS (and all CEDS for that matter), it is important to identify what values are important for stakeholders.This paper examines the CEADS to identify the most critical values for potential stakeholders of this data space. We implement a six-phase value-sensitive design methodology called ‘value mapping’ by interviewing stakeholders from an incipient Spanish data-sharing initiative (potentially representing over 1 million farmers) and conducting a workshop with 42 international stakeholders at an agri-tech summit. Our findings demonstrate the different values that are important for stakeholders of an agricultural data space: farmers (privacy, control, and trust); farm advisors (human welfare and autonomy); farmer associations (trust and human welfare); technology providers and intermediaries (autonomy and human welfare); public and regulatory bodies (autonomy); and society (justice). Furthermore, we describe different interdisciplinary steps to ensure and protect these values to ensure sovereignty-by-design in the CEADS.
Integrative biomechanics of a human–robot carrying task: implications for future collaborative work
Authors: Schuengel Verena , Braunstein Bjoern , Goell Fabian , Braun Daniel , Reißner Nadine , Safronov Kirill , Weiser Christian , Heieis Jule , Albracht Kirsten 
Published: January 2025

AbstractPatients with sarcopenia, who face difficulties in carrying heavy loads, may benefit from collaborative robotic assistance that is modeled after human–human interaction. The objective of this study is to describe the kinematics and spatio-temporal parameters during a collaborative carrying task involving both human and robotic partners. Fourteen subjects carried a table while moving forward with a human and a robotic partner. The movements were recorded using a three-dimensional motion capture system. The subjects successfully completed the task of carrying the table with the robot. No significant differences were found in the shoulder and elbow flexion/extension angles. In human–human dyads, the center of mass naturally oscillated vertically with an amplitude of approximately 2 cm. The here presented results of the human–human interaction serve as a model for the development of future robotic systems, designed for collaborative manipulation.