bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvements in self‐confidence and satisfaction with self‐injection after introducing self‐injection of dupilumab in patients with atopic dermatitis
Authors: Ito Makoto , Kamata Masahiro , Ishikawa Takeko , Uchida Hideaki , Suzuki Shoya , Takeshima Ryosuke , Watanabe Ayu , Mizukawa Itsumi , Egawa Shota , Fukaya Saki , Hayashi Kotaro , Fukuyasu Atsuko , Tanaka Takamitsu , Tada Yayoi 
Published: July 2023

AbstractDupilumab was approved for treating adult patients with atopic dermatitis (AD) refractory to topical therapy in Japan in April 2018, and self‐injection of dupilumab has been available since May 2019. Subcutaneous self‐injection of medication has benefits for patients and the healthcare system. However, anxiety about self‐injection, lack of confidence, and the complicated procedure could prevent initiating self‐injection. In this study, we assessed the experience of AD patients treated with dupilumab before and after introducing self‐injection, utilizing the Self‐Injection Assessment Questionnaire (SIAQ). Adult AD patients who received dupilumab by self‐injection and had been treated for more than 3 months after initiating self‐injection in our hospital from March 1, 2020, to June 19, 2021, were included in this study. Patients rated their perceptions about self‐injections using the SIAQ before the first self‐injection and 3 months after initiating self‐injection. Data were collected retrospectively from their charts. Data on 36 patients were analyzed. The mean age was 34.1 ± 11.5 years. Twenty patients used a prefilled auto‐injector, and the others used a prefilled syringe. Scores on self‐confidence and satisfaction with self‐injection significantly improved after introducing self‐injection. Feelings about injections improved in patients over 40 years and in those who felt anxious about self‐injection. A strong correlation in scores between satisfaction with self‐injection and the ease of use was observed. The results were not affected by clinical severity, gender, or device. Our results could encourage patients who dither to introduce self‐injection of dupilumab due to anxiety and/or lack of self‐confidence about self‐injection to initiate self‐injection.
Case series of catheter‐based arrhythmia ablation in 13 pregnant women
Authors: Mladoniczky Sára , Nagy Zsófia , Földesi Csaba , Som Zoltán , Bálint Hajnalka O. , Környei László , Ruzsa Diána , Fődi Eszter , Simor Tamás , Kardos Attila 
Published: July 2023

AbstractBackgroundCatheter ablation is a rarely used procedure to treat arrhythmias during pregnancy.HypothesisIn the case of maternal arrhythmia during pregnancy, zero‐fluoroscopic catheter ablation is preferable to medical treatment.MethodsBetween April 2014 and September 2021, we examined the demographic data, procedural parameters, and fetal and maternal outcomes in pregnant women undergoing ablation at the Gottsegen National Cardiovascular Center and University of Pécs Medical School, Heart Institute.ResultsFourteen procedures (14 electrophysiological studies [EPS], 13 ablations) performed on 13 pregnant women (age 30.3 ± 5.2 years, primipara n = 6) were studied. During EPS, 12 patients had inducible arrhythmias. Atrial tachycardia was confirmed in three, atrioventricular re‐entry tachycardia via manifest accessory pathway (AP) in three, and via concealed AP in one case. Atrioventricular nodal re‐entry tachycardia was confirmed in three and sustained monomorphic ventricular tachycardia in two cases. Eleven radiofrequency ablation (84.6%) and two cryoablation (15.4%) were performed. The electroanatomical mapping system was used in all cases. Transseptal puncture was performed in two cases (15.4%) due to left lateral APs. The mean procedure time was 76.0±33.0 minutes. All procedures were performed without fluoroscopy. No complications occurred. During the follow‐up, arrhythmia‐free survival was achieved in all cases, but in two patients, we used antiarrhythmic drugs (AADs) to achieve it. APGAR score was within the normal range in all cases [median (interquartile range), 9.0/10.0 (9.0–10.0/9.3–10.0)].ConclusionsZero‐fluoroscopic catheter ablation was an effective and safe treatment option for our 13 pregnant patients. Catheter ablation may have less side effects on fetal development than the use of AADs during pregnancy.
Rare Spin Avoided σ‐σ Diradical Planar Tetracoordinate Boron Cluster: A Proto‐Star for Planar Pentacoordination
Authors: Gohain Namrata , Bordoloi Abhik , Kalita Amlan J. , Guha Ankur K. 
Published: July 2023

AbstractWe report a global planar star‐like cluster B3Li3 featuring three planar tetracoordinate boron centres with a rare spin avoided σ‐σ diradical character. The cluster was found to be stable towards dissociation into different fragments. The spin density was found to be localized solely on the three boron atoms in the molecular plane. This spin avoided σ‐σ diradical character leads to the extension of the coordination number to yield a neutral B3Li3H3 and a cationic B3Li3H3+ cluster with three planar pentacoordinate boron centres in their global minimum structures. The planar geometry of the aninonic B3Li3H3− cluster is slightly higher in energy. The planar global clusters were found to maintain planarity in their ligand protected benzene bound complexes, B3Li3(Bz)3, B3Li3H3(Bz)3 and B3Li3H3(Bz)3+ with high ligand dissociation energies offering candidature for experimental detection.
Colonization success of a tree‐killing bark beetle: Geographic variation and mismatch with host preference
Authors: Takagi Etsuro 
Published: July 2023

AbstractThe preference–performance hypothesis (PPH) predicts that female insects maximize their fitness by ovipositing on hosts where their offspring perform the best. The preference–performance relationships in bark beetles are complex because before offspring development can occur in the phloem, adult bark beetles must first successfully invade host trees, and then construct galleries beneath the bark. Therefore, a positive correlation between host preference and successful colonization is necessary for the PPH in bark beetles to hold (i.e., the preference–colonization hypothesis in bark beetles). In this study, through field choice experiments, I investigated the successful colonization of the bark beetle, Polygraphus proximus, within four allopatrically distributed Abies species across a distinct biogeographic boundary in Japan. The results of this study showed that the biogeographic boundary did not limit the successful colonization by P. proximus. I observed that successful colonization was low in A. firma, despite it being an exotic species in the study sites and the most preferred at the study sites, indicating a mismatch between preference and colonization success. Additionally, I observed that A. sachalinensis had a high colonization success rate, even though it was the least preferred species at the study sites.
Working with a sleep‐deprived or a cognitively enhanced team member compromises motivation to contribute to group performance
Authors: Sattler Sebastian , Häusser Jan A. , Faber Nadira S. 
Published: July 2023

AbstractHow does knowing another team member is cognitively impaired or enhanced affect people's motivation to contribute to the team's performance? Building on the Effects of Grouping on Impairments and Enhancements (GIE) framework, we conducted two between‐subjects experiments (Ntotal = 2,352) with participants from a representative, nationwide sample of the working population in Germany. We found that another group member's impairment (sleep deprivation) and enhancement (taking enhancement drugs) lowered participants’ intentions to contribute to the team's performance. These effects were mediated by lowered perceived competence (enhancement and impairment) and warmth (only enhancement) of the other group member. The reason for being impaired or enhanced (altruistic vs. egoistic reason) moderated the indirect effect of the impairment on intended effort via warmth. Our results illustrate that people's work motivation is influenced by the psychophysiological states of other group members. Hence, the enhancement of one group member can have the paradoxical effect of impairing the performance of another.
Geometry‐guided semantic segmentation for post‐earthquake buildings using optical remote sensing images
Authors: Wang Yu , Jing Xin , Xu Yang , Cui Liangyi , Zhang Qiangqiang , Li Hui 
Published: July 2023

AbstractDeep‐learning‐based automatic recognition of post‐earthquake damage for urban buildings is increasingly in demand for rapid and precise assessment of seismic hazards from optical remote sensing images. In this study, a novel loss function fusing geometric consistency constraint (GCC) with cross‐entropy (CE) loss is designed for post‐earthquake building segmentation with complex geometric features across multiple scales. Specifically, the GCC loss incorporates three critical components, namely, split line length, curvature, and area, and enables the exact extraction of the geometric constraints of boundary and region for damaged buildings. Through the optimization of multiple key coefficients of GCC loss, the proposed method achieves significant performance improvements in semantic segmentation, which is attributed to the enhanced ability to identify and capture the pixel relationship near the boundary. Merging GCC in the loss function enables faster and more accurate convergence of predicted values towards the ground truth during the training process, surpassing the performance of the CE loss alone. The results show that the combination of GCC and CE losses achieves the largest validation mIoU of 86.98% for damaged buildings segmentation, which facilitates post‐earthquake assessment with high accuracy. Moreover, incorporating GCC leads to more precise and robust seismic damage segmentation by effectively improving edge closure, removing internal noise, and reducing false‐positive and false‐negative misrecognition. In addition, the GCC term further validates the effectiveness of improving segmentation tasks for other networks (e.g., DeepLabv3+). The GCC‐derived method exhibits its desirable performance on segmentation accuracy, portability, and universality for building recognition with complex geometric features and post‐earthquake scenes.
A qualitative study of factors influencing ePHR adoption by caregivers and care providers of Alzheimer's patients: An extension of the unified theory of acceptance and use of technology model
Authors: Amiri Parastoo , Pirnejad Habibollah , Bahaadinbeigy Kambiz , Baghini Mahdie Shojaei , Khazaee Parviz Rashidi , Niazkhani Zahra 
Published: July 2023

AbstractBackground and AimsAs the nowadays provision of many healthcare services relies on technology, a better understanding of the factors contributing to the acceptance and use of technology in health care is essential. For Alzheimer's patients, an electronic personal health record (ePHR) is one such technology. Stakeholders should understand the factors affecting the adoption of this technology for its smooth implementation, adoption, and sustainable use. So far, these factors have not fully been understood for Alzheimer's disease (AD)‐specific ePHR. Therefore, the present study aimed to understand these factors in ePHR adoption based on the perceptions and views of care providers and caregivers involved in AD care.MethodsThis qualitative study was conducted from February 2020 to August 2021 in Kerman, Iran. Seven neurologists and 13 caregivers involved in AD care were interviewed using semi‐structured and in‐depth interviews. All interviews were conducted through phone contacts amid Covid‐19 imposed restrictions, recorded, and transcribed verbatim. The transcripts were coded using thematic analysis based on the unified theory of acceptance and use of technology (UTAUT) model. ATLAS.ti8 was used for data analysis.ResultsThe factors affecting ePHR adoption in our study comprised subthemes under the five main themes of performance expectancy, effort expectancy, social influence, facilitating conditions of the UTAUT model, and the participants' sociodemographic factors. From the 37 facilitating factors and 13 barriers identified for ePHR adoption, in general, the participants had positive attitudes toward the ease of use of this system. The stated obstacles were dependent on the participants' sociodemographic factors (such as age and level of education) and social influence (including concern about confidentiality and privacy). In general, the participants considered ePHRs efficient and useful in increasing neurologists' information about their patients and managing their symptoms in order to provide better and timely treatment.ConclusionThe present study gives a comprehensive insight into the acceptance of ePHR for AD in a developing setting. The results of this study can be utilized for similar healthcare settings with regard to technical, legal, or cultural characteristics. To develop a useful and user‐friendly system, ePHR developers should involve users in the design process to take into account the functions and features that match their skills, requirements, and preferences.
Cognitive flexibility and emotional self‐regulation of the elderly with Empty nest syndrome: Benefits of acceptance and commitment therapy
Authors: Mahmoudpour Abdolbaset , Ferdousi Kejani Kimia , Karami Mina , Toosi Maryam , Ahmadboukani Soliman 
Published: July 2023

AbstractBackground and AimsEmpty nest syndrome (ENS) is a mental condition that affects both parents. When children leave their parents' home, the parents experience such feelings as unhappiness, loss, fear, inability, difficulty in adjusting roles, and changing their relationships. The present study aimed to evaluate the cognitive flexibility and emotional self‐regulation of the elderly with ENS: benefits of Acceptance and Commitment Therapy (ACT).MethodsThe research method was quasi‐experimental where a pretest‐posttest design was used with a control group. The statistical population included all the elderly with the ENS in Tehran in the academic year of 2019–2020. Thirty of them were selected by convenience sampling method and then stochastically placed in two experimental and control groups. Dennis and VanderWal's Cognitive Flexibility Inventory, and Hofmann and Kashdan's Emotional Self‐Regulatory Questionnaire for data collection in the pretest and posttest phases. Group‐based ACT was implemented on experimental group members in 8 sessions of 90 min, while controls received no intervention. The collected data were analyzed by SPSS version 25 and analysis of covariance.ResultsThe results showed a significant difference between the posttest scores of the experimental and control groups so the group‐based ACT increased the cognitive flexibility and emotional self‐regulation of the experimental group members (p < 0.05).ConclusionsAccording to our results, therapists and health professionals can use ACT for interventions related to the health of the elderly with ENS, especially to improve cognitive flexibility and emotional self‐regulation.
Bonding Analysis of the Ge‐Ge Bonds in the Octagermacubane Ge8(Sit‐butyl2methyl)6
Authors: Pan Sudip , Frenking Gernot 
Published: July 2023

AbstractQuantum chemical calculations have been carried out at the BP86/def2‐SVP level on Ge8(Sit‐butyl2methyl)6(1) and the bonding situation has been analyzed with a variety of methods. The calculated equilibrium geometry of1is in good agreement with the reported x‐ray structure analysis. The D3 correction for dispersion interactions as a sum of pairwise attractions leads to an overestimate of the effect of dispersion forces. Calculations at BP86‐D3(BJ)/def2‐SVP give shorter bonds for Ge(I)−Ge(I) than for Ge(0)−Ge(I), which is in contrast to the experimental values and the BP86/def2‐SVP results. The NBO analysis suggests that the best Lewis structure of1has lone‐pair orbitals at the Ge(0) atoms with occupation numbers of 1.70 e. A lone‐pair character at Ge(0) albeit with less weight is also suggested by the shape of the HOMO, which is an antibonding orbital between the Ge(0) atoms with small contributions from the Ge(I) atoms. The LUMO of1is the corresponding bonding combination of the Ge(0) AOs, which can be explained with the reluctance of the heavier main‐group atoms to s/p hybridization of the valence orbitals. The calculated bond order values suggest significant direct Ge(0)−Ge(0) interactions. This is supported by the shape of the HOMO and by the results of EDA‐NOCV calculations. The deformation densities and the orbitals associated with the pairwise orbital interaction show that there is a direct charge flow between the Ge(0) atoms of the two fragments, but it is not completely separated from the Ge(0)−Ge(I) and Ge(I)−Ge(I) bond formation. The QTAIM calculations suggest that1has a cubic structure with a cage critical point but not a bond critical point for the Ge(0)−Ge(0) interactions. The dispersion interactions of the large substituents in1have a significant influence on the stability of the compound.
Recent advances in ultrathin materials and their applications in e‐skin
Authors: Gao Wenchao , Huang Jiaoya , He Jiang , Zhou Runhui , Li Zemin , Chen Ziyu , Zhang Yufei , Pan Caofeng 
Published: July 2023

AbstractIntelligent technologies based on artificial intelligence and big data hold great potential for health monitoring and human–machine capability enhancement. However, electronics must be connected to the human body to realize this vision. Thus, tissue or skin‐like electronics with high stretchability and low stiffness mechanical properties are highly desirable. Ultrathin materials have attracted significant attention from the research community and the industry because of their high performance and flexibility. Over the past few years, considerable progress has been made in flexible ultrathin sensors and devices based on ultrathin materials. Here, we review the developments in this area and examine representative research progress in ultrathin materials fabrication and device construction. Strategies for the fabrication of stretchable ultrathin materials and devices are considered. The relationship between the thin‐film structure and performance is emphasized and highlighted. Finally, the current capabilities and limitations of ultrathin devices were explored.image
Field‐scale measurements of soil physico‐chemical profiles of the Potohar region in the Indus basin of Pakistan
Authors: Malik Manzoor Ahmad , Ashraf Muhammad 
Published: July 2023

AbstractSoil physico‐chemical properties are important for best management practices. We measured infiltration, bulk density, texture, water retention and chemical profiles from the surface to 1.0 m and lithology to 50 m depths at 30 sites. The infiltration data were fitted to the cumulative and infiltration rate models of Philip and Horton. The same sites were used for water retention, physico‐chemical properties and lithological assessment. The cumulative models fit persistently better than their infiltration rate forms. The Horton cumulative model fitted statistically better than the corresponding Philip model. The dominant steady‐state infiltration rates were 15–30 and 30–45 mm h−1 over the entire profile. Sandy loam, loam and silt loam were the dominant soils. The percentages of sandy loam decreased, whereas silt loam increased, with depth. Water retention parameters and lithological strata were diverse and in harmony with physiography. Soil organic matter varied up to 2.5%. No sodicity or salinity was detected except in sparse saline seeps. The central tendency and extrema of the measured parameters were compatible with the literature, and the CVs of the soil hydraulic parameters were greater than those of the physical parameters. Comprehensive data are presented, which will serve as an important reference for regional and global repositories.
Influences of lysine‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo
Authors: Yuan Jialin , Que Ruiman , Zhao Weichao , Song Fengmei , Cao Yi , Yu Bin 
Published: July 2023

AbstractLysine‐specific demethylase 1 (LSD1) inhibitors are being developed for cancer therapy, but their bioeffects on vasculatures are not clear. In this study, we compared the influences of ORY‐1001 (an LSD1 inhibitor being advanced into clinical trials) and 199 (a novel LSD1 inhibitor recently developed by us) to human umbilical vein endothelial cells (HUVECs) in vitro and further verified the bioeffects of ORY‐1001 to zebrafish (Danio rerio) larvae in vivo. The results showed that up to 10 μM ORY‐1001 or 199 did not significantly affect the cellular viability of HUVECs but substantially reduced the release of inflammatory interleukin‐8 (IL‐8) and IL‐6. The signaling molecule in vasculatures, NO, was also increased in HUVECs. As the mechanism, the protein levels of endothelial NO synthase (eNOS) or p‐eNOS, and their regulators Kruppel‐like factor 2 (KLF2) or KLF4, were also increased after drug treatment. In vivo, 24 h treatment with up to 100 nM ORY‐1001 reduced blood speed without changing morphologies or locomotor activities in zebrafish larvae. ORY‐1001 treatment reduced the expression of il8 but promoted the expression of klf2a and nos in the zebrafish model. These data show that LSD1 inhibitors were not toxic but capable to inhibit inflammatory responses and affect the function of blood vessels through the up‐regulation of the NOS‐KLF pathway.
Autophagy regulation by inorganic, organic, and organic/inorganic hybrid nanoparticles: Organelle damage, regulation factors, and potential pathways
Authors: Qiao Dong , Zhang Ting , Tang Meng 
Published: July 2023

AbstractThe rapid development of nanotechnology requires a more thorough understanding of the potential health effects caused by nanoparticles (NPs). As a programmed cell death, autophagy is one of the biological effects induced by NPs, which maintain intracellular homeostasis by degrading damaged organelles and removing aggregates of defective proteins through lysosomes. Currently, autophagy has been shown to be associated with the development of several diseases. A significant number of research have demonstrated that most NPs can regulate autophagy, and their regulation of autophagy is divided into induction and blockade. Studying the autophagy regulation by NPs will facilitate a more comprehensive understanding of the toxicity of NPs. In this review, we will illustrate the effects of different types of NPs on autophagy, including inorganic NPs, organic NPs, and organic/inorganic hybrid NPs. The potential mechanisms by which NPs regulate autophagy are highlighted, including organelle damage, oxidative stress, inducible factors, and multiple signaling pathways. In addition, we list the factors influencing NPs‐regulated autophagy. This review may provide basic information for the safety assessment of NPs.