bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sodium intake reduction on blood pressure control in hypertensive patients
Authors: Upadhyay Ronak Brijeshkumar , Panjiyar Binay K , Agarwal Abhimanyu , Patel Dhwani Manishbhai , Ghotra Monica , Husain Mahato Gulam Husain Nabi 
Published: September 2023

AbstractThe primary objective of this research was to delve into the impact of sodium reduction on managing blood pressure in individuals with hypertension. The investigation entailed a thorough examination of pertinent literature, concentrating on experimental inquiries, meta-analyses, and clinical studies spanning the years 2013 to 2022. The focus encompassed an array of scholarly works that go through the intricate link between sodium consumption and the regulation of blood pressure. These diverse studies yielded noteworthy outcomes, consistently portraying a proportional response to salt reduction. Notably, the reduction in sodium intake showcased a significant reduction in blood pressure levels among hypertensive patients. The underpinnings of this phenomenon were scrutinized, encompassing variations in renin, aldosterone, catecholamine, cholesterol, and triglyceride levels. Furthermore, these studies give the interplay of salt reduction with dietary interventions and the baseline blood pressure, accentuating the potential for custom-tailored methodologies to optimize blood pressure management. In recent times, lifestyle interventions targeting sodium intake have gained escalated consideration, and the effectiveness of these interventions in lowering blood pressure among hypertensive patients has been substantiated through randomized controlled trials. These findings underscore the pivotal role of curtailing sodium intake as a potent strategy for controlling blood pressure effectively in the hypertensive demographic. Nonetheless, further exploration is warranted to delve into prolonged outcomes, refine dietary recommendations, and formulate comprehensive strategies for fine-tuning blood pressure control through judicious sodium reduction.
A machine-learning method for biobank-scale genetic prediction of blood group antigens
Authors: Hyvärinen K , Haimila K , Moslemi C ,   Blood Service Biobank, Olsson ML , Ostrowski SR , Pedersen OB , Erikstrup C , Partanen J , Ritari J 
Published: September 2023

ABSTRACTBlood transfusion is a life-saving medical procedure performed routinely worldwide. A key element for successful transfusion is compatibility of the patient and donor red blood cell (RBC) antigens. Precise antigen matching reduces the risk for immunization and other adverse transfusion outcomes. RBC antigens are encoded by specific genes, which allows developing computational methods for determining antigens from genomic data.We describe here a classification method for determining RBC antigens from genotyping array data. Random forest models for 39 RBC antigens in 14 blood group systems and for human platelet antigen (HPA)-1 were trained and tested using genotype and RBC antigen and HPA-1 typing data available for 1,192 blood donors in the Finnish Blood Service Biobank. The algorithm and models were further evaluated using a validation cohort of 111,667 Danish blood donors.In the Finnish test data set, the median (interquartile range [IQR]) balanced accuracy for 39 models was 99.9 (98.9–100)%. We were able to replicate 34 out of 39 Finnish models in the Danish cohort and the median (IQR) balanced accuracy for classifications was 97.1 (90.1– 99.4)%. When applying models trained with the Danish cohort, the median (IQR) balanced accuracy for the 40 Danish models in the Danish test data set was 99.3 (95.1–99.8)%.The RBC antigen and HPA-1 prediction models demonstrated high overall accuracies suitable for probabilistic determination of blood groups and HPA-1 at biobank-scale. Furthermore, population-specific training cohort increased the accuracies of the models. This stand-alone and freely available method is applicable for research and screening for antigen-negative blood donors.
GeneSetR: A web server for gene set analysis based on genome-wide Perturb-Seq data
Authors: Kuzu Omer F. , Saatcioglu Fahri 
Published: September 2023

ABSTRACTIdentification of genotype-phenotype relationships is of utmost importance and a core effort in biology. Recent developments in efficient and precise gene targeting approaches coupled to omics methods have significantly improved deciphering of molecular interactions and relationships. However, many single gene perturbations can affect the expression of hundreds of other genes and analysis of the resulting omics-derived gene lists currently remains a significant challenge. Here we present Perturb-Seq based Gene Set Analyzer (GeneSetR), a user-friendly web-server that can analyze user-defined gene lists based on the data from a recently published genome-wide Perturb-Seq study, which targeted 9,866 genes with 11,258 sgRNAs in the K562 cell line. Through this tool, users can cluster gene lists following dimensionality reduction by various algorithms, undertake network analysis from RNA sequencing data, identify key nodes among the submitted genes, perform gene signature analyses, and generate heatmaps based on perturbation or gene expression data. GeneSetR enables researchers to readily identify gene clusters associated with specific phenotypes or biological processes, providing insights into the potential functional roles of these clusters and the role of single genes in them. With robust analysis capabilities, GeneSetR is a powerful resource to facilitate the exploration of genotype-phenotype relationships.
Probing Molecular Diversity and Ultrastructure of Brain Cells with Fluorescent Aptamers
Authors: Lu Xiaotang , Wu Yuelong , Li Peter H. , Fang Tao , Schalek Richard L. , Su Yaxin , Carter Jeffery D. , Gupta Shashi , Jain Viren , Janjic Nebojsa , Lichtman Jeff W. 
Published: September 2023

AbstractDetergent-free immunolabeling has been proven feasible for correlated light and electron microscopy, but its application is restricted by the availability of suitable affinity reagents. Here we introduce CAptVE, a method using slow off-rate modified aptamers for cell fluorescence labeling on ultrastructurally reconstructable electron micrographs. CAptVE provides labeling for a wide range of biomarkers, offering a pathway to integrate molecular analysis into recent approaches to delineate neural circuits via connectomics.
From traditional advertising to digital marketing: exploring electronic word of mouth through a theoretical lens in the hospitality and tourism industry
Authors: Jan Amin , Khan Mehmood , Ajmal Mian M. , Patwary Ataul Karim 
Published: September 2023

Purpose
Considering the transition of communicational channels from physical to digital spaces, this study aims to provide a theoretical foundation for understanding engagement in electronic word of mouth (eWoM) among managers and customers in the hospitality and tourism industry.

Design/methodology/approach
This study uses the four aggregate dimensions, namely, performance expectancy, efforts expectancy, social influence and facilitations condition. Further, this paper uses the 14 second-order themes of the Unified Theory of Acceptance and Use of Technology with a data set that represents elements that can trigger eWoM, both from managers’ and customers’ perspectives. The process of data structuration follows thematic analysis and axial coding techniques.

Findings
The results of this study show that performance expectancy, facilitation conditions, social influence and effort expectancy all trigger positive eWoM generation in the hospitality and tourism industry indicating customers’ and managers’ perspectives.

Originality/value
This novel study provides a theoretical foundation and novel propositions for future research work on the role of novel antecedents that can trigger eWoM in the hospitality and tourism industry. This paper also provides a benchmark for practitioners and policymakers in their strategic decisions-making towards improving business performance through positive eWoM.
Moving into the metaverse: libraries in virtual worlds
Authors: Oladokun Bolaji David , Yahaya Dauda Oseni , Enakrire Rexwhite Tega 
Published: September 2023

Purpose
As traditional physical spaces grapple with evolving reading habits and information consumption patterns, the notion of libraries within the metaverse poses intriguing questions about accessibility, knowledge dissemination and the evolving role of librarians. The purpose of this paper is to explore the role of metaverse in virtual libraries.

Design/methodology/approach
This paper analyzes various literature relating to libraries and the metaverse in the virtual worlds through a review of the literature.

Findings
In the ever-evolving landscape of information and technology, the emergence of libraries in virtual worlds presents a transformative paradigm that brings forth both tremendous advantages and intricate challenges. These advantages are underscored by enhanced accessibility for a global audience, interactive engagements that cater to diverse learning styles and the unprecedented scalability that digital environments provide. Virtual libraries hold the potential to reshape the way people access, share and engage with knowledge, while also fostering a sense of community that transcends geographical boundaries.

Originality/value
To the best of the authors’ knowledge, this paper is the original idea that highlights the importance of metaverse in virtual libraries.
All my rowdy friends: the effect of Super Bowl hosting on audit and financial reporting timeliness
Authors: Crook Matthew D. , Lambert Tamara A. , Walkup Brian R. , Whitworth James D. 
Published: September 2023

Purpose
The purpose of this paper is to examine the impact hosting the Super Bowl has on audit completion and financial reporting timeliness for companies headquartered in Super Bowl hosting cities.

Design/methodology/approach
Using 16 years of financial reporting data, this study uses the Super Bowl and related activities, combined with required filings during “busy season,” as a natural experiment to examine how audit firms navigate short-term, exogenously imposed but anticipated, audit team capacity constraints.

Findings
Companies headquartered in a city hosting the Super Bowl, during busy season, have longer audit report lags (by approximately three days, in comparison to non-hosting busy season audits) and less timely securities and exchange commission (SEC) (10-K) filings. The authors find no evidence that Super Bowl hosting affects audit fees or earnings announcement timeliness.

Practical implications
When confronted with anticipated capacity shocks, audit firms take longer to complete the audit, absorbing the financial costs of the delay and maintaining audit quality, resulting in less timely financial reporting.

Originality/value
This study demonstrates the costs of Super Bowl-related inefficiencies and contributes to our understanding of how auditors navigate capacity shocks. This study provides evidence that auditors can effectively manage business risk and continue to facilitate providing timely and accurate information to financial statement users in the face of a capacity shock.
Synthesis of butylated benzo-amino resin by solid formaldehyde one-step-two-stage method and its application in high solid content coatings
Authors: Yang Xingbing , Wang Xinye , Huang Shuang , Liu Xin , Huang Xiang , Lei Ting 
Published: September 2023

Purpose
In this study, solid formaldehyde, benzoguanamine and butanol were used to synthesize butylated benzo-amino resin by one-step-two-stage method.

Design/methodology/approach
This research first examined the influence of solid formaldehyde content on the hydroxymethylation phase. Subsequently, the effects of butanol content, etherification time and hydrochloric acid content on the formation of benzo-amino resin during the etherification stage were studied in detail. In addition, the reaction process was further analyzed through interval sampling withdrawing during the hydroxymethylation and etherification stages. Finally, the synthesized benzo-amino resins were used in the production of high solid content polyester and acrylic coatings and the properties of that were also evaluated.

Findings
Based on the experimental findings, the authors have successfully determined the optimal process conditions for the one-step-two-stage method in this study. The hydroxymethylation stage demonstrated the most favorable outcomes at a reaction temperature of 60°C and a pH of 8.5. Similarly, for the etherification stage, the optimal conditions were achieved at a temperature of 45°C and a pH of 4.5. Furthermore, the investigation revealed that a ratio of benzoguanamine to solid formaldehyde to n-butanol, specifically at 1:5.2:15, produced the best results. The performance of the resulting etherified benzo-amino resin was thoroughly evaluated in high solid content coatings, and it exhibited promising characteristics. Notably, there was a significant enhancement in the water resistance, solvent resistance and glossiness of canned iron printing varnish coatings.

Originality/value
Amino resin, a versatile chemical compound widely used in various industries, presents challenges in terms of sustainability and operational efficiency when synthesized using conventional methods, primarily relying on a 37% formaldehyde solution. To address these challenges, the authors propose a novel approach in this study that combines the advantages of the solid formaldehyde with a two-stage catalytic one-step synthesis process. The primary objective of this research is to minimize the environmental impact associated with amino resin synthesis, optimize resource utilization and enhance the economic feasibility for its industrial implementation. By adopting this alternative approach, the authors aim to contribute toward a more sustainable and efficient production of amino resin.
USA–Myanmar relations: democratization and beyond
Authors: Zreik Mohamad 
Published: September 2023

PurposeThis paper aims to examine the USA's policy toward Myanmar or Burma, analyzing the bilateral relationship between the two countries from the pre-colonial period to the present day. It highlights the implications of political shifts in the system of government in Myanmar for the bilateral relationship with the USA, particularly after the 1962 coup and the emergence of rising regional powers like China. The paper also shows how the economic role of Myanmar has increased, leading to more equal relations with the United States of America.Design/methodology/approachThis paper employs a qualitative research design, analyzing data from both primary and secondary sources. The methodology includes a literature review and document analysis to gain a comprehensive understanding of the USA–Myanmar bilateral relationship. The research also analyzes political and economic developments in Myanmar and the region, placing the USA policy in a broader context.FindingsThe research finds that the USA has been an influential player in Myanmar's politics and economy. However, with Myanmar's integration into the Chinese Belt and Road Initiative and its accession to Association of Southeast Asian Nations (ASEAN), its economic role has become more significant, leading to a more balanced relationship with the USA. The paper also shows that the USA's policy toward Myanmar has undergone significant changes, particularly after the 2011 easing of sanctions by former President Barack Obama.Originality/valueAlthough many works have traced the history of USA–Myanmar ties, this study provides a fresh perspective by setting past events against the backdrop of contemporary geopolitical upheavals, therefore highlighting the complex evolution of their bilateral dynamics. The paper contributes to the literature on the USA–Myanmar bilateral relationship by providing a comprehensive analysis of the relationship from a historical perspective. The research also adds to the discussion of the implications of political and economic developments in Myanmar for the bilateral relationship with the USA. The findings of this study have important implications for policymakers and scholars interested in the USA's role in Southeast Asia and its relations with rising regional powers like China.
A tool to profile neural, sensory and motor development in children at school entry, identifying possible barriers to learning and emotional well‐being in early childhood
Authors: Hannant Penelope , Gartland Rachael , Eales Helen , Mooncey Sophia 
Published: September 2023

AbstractThe objective of the study was to develop a prototype for an accessible, high quality, cost and time‐effective ‘Development Profiling Tool’ for use in reception classes. This would build a unique picture of every individual child's developmental at the beginning of their educational journey, meaning that interventions for any comparable areas of difficulty could be started early in the child's schooling. In this study, a prototype of the tool was developed and tested for reliability, validity and usability. Through content analysis of a range of screeners and the merging of targeted expertise, a single 54 question observational questionnaire was constructed that incorporated the five developmental domains considered to impact on learning and emotional well‐being: auditory skills; internal senses (proprioception and vestibular input); external senses (auditory, visual and tactile responsivity); fine motor skills and gross motor skills. Thus, the Development Profiling Tool was created.Key pointsFor a child to learn successfully a number of developmental building blocks need to be present.These include effective sensory responsivity and motor coordination.This study develops a Developmental Profiling Tool to map every child's development at the start of their schooling.The study also tests the prototype for reliability, validity and usability.
PROPERTY’S SHADOW: Governing Land and Plurality in Durban, South Africa
Authors: Pieterse Marius , Coggin Thomas 
Published: September 2023

AbstractProperty as a legal assemblage works to produce and imagine space according to a dominant set of norms and principles, thereby casting an imagined projection into multiple worlds. This unduly narrows the lens through which governance actors perceive and mediate competing claims to urban space. In this article we engage this feature of property in the context of contestation over urban land in Durban, an intensely plural city of the global South. We focus on three sets of spatial practices that are, in different ways, in tension with municipal governance objectives in Durban to probe how social actors interface with property law through divergent logics and lexicons. We argue that a more hybrid legal conception of property is required to enable just and normatively hybrid governance of these (often competing) claims.
Prediction of labour outcomes using prelabour computerised cardiotocogram and maternal and fetal Doppler indices: A prospective cohort study
Authors: Moungmaithong Sakita , Lam Michelle Sung Nga , Kwan Angel Hoi Wan , Wong Sani Tsz Kei , Tse Ada Wing Ting , Sahota Daljit Singh , Tai Sin Ting Angela , Poon Liona Chiu Yee 
Published: September 2023

AbstractObjectivesTo investigate the association and the potential value of prelabour fetal heart rate short‐term variability (STV) determined by computerised cardiotocography (cCTG) and maternal and fetal Doppler in predicting labour outcomes.DesignProspective cohort study.SettingThe Prince of Wales Hospital, a tertiary maternity unit, in Hong Kong SAR.PopulationWomen with a term singleton pregnancy in latent phase of labour or before labour induction were recruited during May 2019–November 2021.MethodsPrelabour ultrasonographic assessment of fetal growth, Doppler velocimetry and prelabour cCTG monitoring including Dawes–Redman CTG analysis were registered shortly before induction of labour or during the latent phase of spontaneous labour.Main outcome measuresUmbilical cord arterial pH, emergency delivery due to pathological CTG during labour and neonatal intensive care unit (NICU)/special care baby unit (SCBU) admission.ResultsOf the 470 pregnant women invited to participate in the study, 440 women provided informed consent and a total of 400 participants were included for further analysis. Thirty‐four (8.5%) participants underwent emergency delivery for pathological CTG during labour. A total of 6 (1.50%) and 148 (37.00%) newborns required NICU and SCBU admission, respectively. Middle cerebral artery pulsatility index (MCA‐PI) and MCA‐PI z‐score were significantly lower in pregnancies that required emergency delivery for pathological CTG during labour compared with those that did not (1.23 [1.07–1.40] versus 1.40 [1.22–1.64], p = 0.002; and 0.55 ± 1.07 vs. 0.12 ± 1.06), p = 0.049]. This study demonstrated a weakly positive correlation between umbilical cord arterial pH and prelabour log10 STV (r = 0.107, p = 0.035) and the regression analyses revealed that the contributing factors for umbilical cord arterial pH were smoking (p = 0.006) and prelabour log10 STV (p = 0.025).ConclusionsIn pregnant women admitted in latent phase of labour or for induction of labour at term, prelabour cCTG STV had a weakly positive association with umbilical cord arterial pH but was not predictive of emergency delivery due to pathological CTG during labour.
Spatial pattern and driving forces of regional water use efficiency: From spatial spillover and heterogeneity perspective
Authors: He Yanhu , Liu Binfen , Gong Zhenjie 
Published: September 2023

AbstractWater use efficiency (WUE) is critical for conserving water resources and protecting the environment, yet the lack of quantitative analysis of its spatial spillover effects and the spatial heterogeneity of its influencing factors hinders improving and achieving the spatial equilibrium regulation of regional WUE. In the current study, a way is proposed to explore the spatial pattern and driving forces of regional WUE from spatial spillover and heterogeneity perspective, in which the Improved Super‐slack‐based Model is firstly applied to estimate the WUE, and then, the spatial Markov chain and the geographically and temporally weighted regression model were, respectively, used to explore the spatial spillover effects of WUE and reveal the spatial heterogeneity of the driving forces behind the WUE. Guangdong Province, a region with rapidly developing economy and significant uneven development in China, was chosen as a case study. Results show that there is a radial pattern of high WUE in the Pearl River Delta and there are significant spatial spillover effects among cities, the city with higher WUE exerted positive effects on its neighboring city's WUE. The key driving factors of WUE include per capita GDP, per capita water consumption, proportion of secondary and tertiary industry water use, foreign direct investment, and R&D input, with spatial heterogeneity in their influences. Policies such as enhancing public awareness of water saving, increasing the reuse of wastewater in industrial parks, and promoting the inter‐municipal socioeconomic and technological exchanges are recommended to achieve a more coordinated and balanced regional WUE. The results of this study have scientific and practical implications for coordinating regional water resources exploitation and sustainable development.