bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban–rural differences in the relationship between stunting, preschool attendance, home learning support, and school readiness: A study in Côte d'Ivoire
Authors: Brou Abenin Mathieu , Djalega Franck Adjé , Tokpa Venance , Seri Edy Constant Gbala , Anoua Apie Léa Fabienne , Robinson Julie Ann 
Published: January 2023

BackgroundStunted physical growth during early childhood is a marker of chronic undernutrition, and the adverse life circumstances that underlie it. These have the potential to disrupt normal brain development and the acquisition of foundational cognitive, language, social and motor skills. Stunting is prevalent in most low-and middle-income countries. Because the prevention of stunting requires large-scale structural and attitudinal changes, several psycho-educational interventions have been developed to mitigate the adverse association between early stunting and skill development. However, the resource-intensive nature of custom-designed interventions limit their sustainability and scalability in resource-limited settings. This study explored the possibility that available resources that promote positive development (existing preschool education programs, and no- or low-cost home-based learning activities and resources) may protect against any negative association between stunting and the acquisition of foundational skills required for academic learning and adaptation at school.MethodData for 36-to 59-month-old children (n = 3,522; M = 46.7 months; 51.2% male; 74.1% rural) were drawn from the most recent Multiple Indicator Cluster Survey conducted in Côte d'Ivoire (MICS5, 2016). Stunting was assessed using the WHO Child Growth Standards. Preschool attendance and home learning activities and resources were assessed by maternal report. School readiness was assessed using the 8-item form of the Early Child Development Index (ECDI).ResultsA high percentage of children met the criteria for stunting (28.5%; 19.7% moderate; 8.8% severe). There were marked urban–rural differences in the prevalence of stunting, rates of preschool attendance, home learning activities and resources, children's school readiness scores, and the relationships between stunting, the protective factors and school readiness scores. These urban–rural differences in ECDI scores could be fully explained by differences between these settings in stunting and the protective factors. However, only two protective factors (access to books and home-based activities that promote learning) made independent contributions to variance in ECDI scores. There was tentative evidence that stunted children whose homes provided highly diverse learning activities and multiple types of learning resources were more likely than those who did not to have a high level of school readiness.ConclusionCapitalizing on the existing practices of families that show positive deviance in caregiving may provide a basis for culturally appropriate, low-cost interventions to improve school readiness among children in low- and middle-income countries, including children with stunted growth.
A study on differences about the influencing factors of depressive symptoms between medical staff and residents during 2022 city-wide temporary static management period to fighting against COVID-19 pandemic in Shanghai
Authors: Zhao Ying , Tao Yiran , Bao Xiwen , Ding Qiang , Han Changyan , Luo Tingkun , Zhang Weijia , Sun Jinhua , Shi Jiali 
Published: January 2023

ObjectivesOur study aimed to identify the latent class of depressive symptoms in the Shanghai population during the city-wide temporary static management period and compare differences in the factors influencing depressive symptoms between medical staff and residents.MethodsAn online cross-sectional survey was conducted with 840 participants using questionnaires, including Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Pittsburgh Sleep Quality Index (PSQI), and self-compiled questionnaire (demographic characteristics and internet usage time). Latent class analysis (LCA) was performed based on participants' depressive symptoms. The latent class subgroups were compared using the chi-square test and t-test. Logistic regression was used in our study to analyze the factors influencing depressive symptoms within the medical staff group and residents group and then compare their differences.ResultsTwo distinct subgroups were identified based on the LCA: the group with low-depressive symptoms and the group with high-depressive symptoms. There were significant differences between the two groups (P &lt; 0.05) on age, education level, marital status, internet usage time, identity characteristics (medical staff or residents), family income level, living style, overall quality of sleep, and anxiety levels. Furthermore, logistic regression analysis results showed that compared with the residents group, the participants in the group of medical staff with “increasing internet usage time” and the “daytime dysfunction” would have nearly two times the possibility of getting serious depressive symptoms.ConclusionsThere are differences in the factors influencing depression symptoms between medical staff and residents during the 2022 city-wide temporary static management period to fighting against the COVID-19 pandemic in Shanghai. We should pay special attention to those with increasing internet usage time and daytime dysfunction in medical staff working in a special environment such as the COVID-19 pandemic.
Predictors of vitamin A rich food consumption among women living in households growing orange-fleshed sweetpotatoes in selected regions in Uganda
Authors: Nankumbi Joyce , Grant Frederick K. E. , Sibeko Lindiwe , Mercado Evelyn , Kwikiriza Norman , Heck Simon , Cordeiro Lorraine S. 
Published: January 2023

ObjectiveVitamin A deficiency (VAD) has serious public health consequences including morbidity and mortality for populations in low and middle-income countries (LMICs), especially for children under 5 years and pregnant women. LMICs are at greater risk of VAD, in part due to low levels of consumption of vitamin A-rich foods most of which are plant-based, such as orange-fleshed sweet potatoes (OFSP), with lower bioavailability than animal sources of the vitamin A. Food-based approaches such as biofortification of OFSP, including promoting the consumption of vitamin A-rich biofortified staple crops, has been shown to be potentially effective in improving the status of vitamin A and other micronutrients. This study examined vitamin A-rich food consumption and its predictors among women of reproductive age from OFSP-growing households in two regions of Uganda.MethodsA cross-sectional survey was conducted among 617 OFSP growing households, focusing on women in the reproductive age group from the northern and eastern regions of Uganda. Households were not receiving any VAD-related intervention at the time of the survey. Quantitative data included vitamin A-rich food consumption, knowledge on vitamin A, and rich food sources dietary intake, using a 7-day food frequency questionnaire. Vitamin A consumption and risk of deficiency were estimated using the Hellen Keller International guide.ResultsThe majority of women in this study were either pregnant (80%) or lactating (17%). More than 70% of the study population had a weighted vitamin A rich food consumption mean score of &lt;6 days per week, indicating a high risk of VAD. Knowledge about vitamin A [b (SE) = −0.18 (0.50), p &lt; 0.001] was significantly and inversely associated with vitamin A rich food consumption.ConclusionComponents of food insecurity such as availability, affordability, utilization, and changing food preferences may contribute to the unexpected inverse relationship between knowledge and consumption of vitamin A rich foods. Scaling up biofortified food initiatives, including OFSP, can improve consumption of vitamin A rich foods with effective strategies to comprehensively address consumption barriers such as lack of nutrition education, cooking skills, and storage facilities, as well as low production levels and perceived contamination of biofortified foods.
Translating tools and indicators in territorial RRI
Authors: Völker Thomas , Mazzonetto Marzia , Slaattelid Rasmus , Strand Roger 
Published: January 2023

IntroductionBy a series of calls within the Horizon 2020 framework programme, the EU funded projects intended to deploy Responsible Research and Innovation (RRI) at a territorial level, in regional research and innovation ecosystems. This paper presents efforts to document and evaluate the achievements in TRANSFORM, one of these projects.MethodsEvaluative inquiry and theoretical reasoning.ResultsNoting the need for a general principle to be interpreted, adapted and translated in order to be rendered meaningful at a local level, we studied precisely these multiple territorial translations of RRI, the organizational and institutional orderings with which they co-emerge and the challenges that come with these translations. An important shared feature is that RRI work does not start from zero, but rather builds on pre-existing relationships and repertoires of collaboration. The RRI project is hence a way to continue ongoing work and follow pre-set purposes, aims and objectives, as a form of “maintenance work”. In this very human sense, RRI is deployed with a logic of care in the regional context, while the Horizon 2020 calls and proposals above all are formulated in a logic of choice, to be assessed by indicators.DiscussionWe warn against undue standardization of RRI by toolification and use of quantitative indicators, and recommend that RRI performance is monitored by methods of evaluative inquiry.
Pilot study of personalized sleep-coaching messages to promote healthy sleeping behaviors
Authors: Schneider Logan D. , Barakat Andrew , Ali Zainab , Concepcion Christian , Taylor James A. , Jiang Allen 
Published: January 2023

ObjectivesAssess a program of sleep schedule recommendations and behavior change “nudges” algorithmically selected using passively collected, longitudinal sleep data. Improvements were primarily measured by sleep schedule adherence and changes in sleep health (quantified by the RU_SATED framework).MethodsThis study used a convenience sample of self-screening volunteers, responding to recruitment emails. Sleep data was gathered with a commercial under-mattress sensor through three phases: baseline passive data collection-2 weeks; intervention-4 weeks; maintenance monitoring passive data collection-8 weeks. The intervention included sleep schedule recommendations and SMS “nudges,” based on rules and recommendations derived from the extant literature. A daily sleep-health score (based on RU_SATED) was derived from passively collected sleep data and daily self-reports of alertness and sleep quality.ResultsTwenty-six participants (34.92 ± 10.08-years-old; 20M:6F) had adequate data for analysis. The main findings were: (1) Adherence—defined as a wake time (WT) within 30 min of the recommendation—rates did not differ significantly between the three study phases. However, there was a general decline in adherence over the course of the study, with adherence rates dropping by about 1.5%/week in a pattern of progressive delay of WTs. (2) Linear mixed models (LMMs) of individual sleep metrics did not demonstrate a significant change over the course of the intervention, possibly due to widely varying, yet relatively healthy, sleep patterns at baseline. (3) Comparatively, the composite, sleep-health (RU_SATED) score demonstrated general improvement over the intervention period, in association with higher rates of WT adherence.ConclusionsWhile, in general, adherence to a sleep schedule and individual dimensions of sleep health did not demonstrate meaningful improvements during the intervention phase, those individuals that were more consistently meeting the wake-time schedule recommendation had associated improvements in their overall sleep-health. As such, this pilot study demonstrates the feasibility and potential efficacy among more adherent individuals of implementing a sleep wellness coaching framework using passively collected sleep data and a rule-based coaching infrastructure.
Which animal-to-feeding-place ratio at time-controlled hay racks is animal appropriate? Preliminary analysis of stress responses of horses
Authors: Baumgartner Miriam , Erhard Michael H. , Zeitler-Feicht Margit H. 
Published: January 2023

IntroductionAutomated feeding systems offer numerous advantages for animals and humans, but the associated benefits and risks can often only be seen under practical conditions. The space allowance (~80 cm per horse) at time-controlled hay racks for horses in group housing, unlike at partitioned feeding stands or transponder-controlled feed stations, currently falls below the required individual distance between the horses, which can result in a high level of aggression between the horses due to the lack of partitions between them. Hence, a feed-through at a time-controlled hay rack cannot be equated with a feeding place. In this preliminary study, we therefore aimed to determine the minimum animal-to-feeding-place ratio (AFR) at time-controlled hay racks that would provide adequate individual distances between the horses.MethodsTo do so, we assessed behavioral and physiological parameters (via video behavioral observations and salivary cortisol measurements) of up to 28 horses in a loose housing system. Over 2 observation days per treatment, four AFRs were investigated in a balanced sequence: 1:1.2, 1:2, 1:3, and C (single feeding in familiar surroundings as a control).ResultsWe found that the horses expressed less aggressive behavior, especially those behaviors with a high risk of injury such as biting and kicking, when there were three times as many openings as there were horses at time-controlled hay racks, as compared with only 20% more openings or twice as many openings as there were horses [lineal mixed model: F(3, 4) = 7.411; adjusted R2 = 0.733; p(AFR_1:2) = 0.06, p(AFR_1:3) = 0.02, p(AFR_C) = 0.01]. The salivary cortisol levels during feeding decreased more strongly with more generous AFRs [p(AFR_metric) = 0.02]. The factors hierarchy and individual showed no influence. In contrast, the day of the experiment and the associated weather conditions, despite randomized selection, influenced both the behavioral and the physiological parameters.DiscussionThe results of this preliminary study indicate that the investigated time-controlled hay racks must provide at least three times as many feeding places as there are horses to ensure that neighboring horses can keep their individual distance and stress-free feeding is possible. Further studies on more farms and different types as well as arrangement of hay racks are proposed.
Epidermal growth factor regulates autophagy activity and endocytosis of yak cumulus cells in a concentration-dependent manner
Authors: Ma Rui , Yu Sijiu , Cui Yan , Pan Yangyang , Wang Meng , Wang Libin , Wang Jinglei , Zhao Ling , Zhang Hui 
Published: January 2023

IntroductionAutophagy and endocytosis are crucial biological activities in mammalian follicle development and oocyte maturation, which are easily affected by external environmental factors. Epidermal growth factor (EGF), as an important component of follicular fluid, regulates the growth and apoptosis of follicular cells. However, its regulatory mechanism of autophagy and endocytosis in mammals, especially in large domestic animals such as plateau yak, remains unclear. This study aimed to investigate the regulatory mechanism of EGF on autophagy and endocytosis in yak cumulus cells.MethodsYak cumulus cells were treated with different concentrations of EGF and appropriate concentrations of EGFR inhibitor gefitinib (10 μM). The dynamic expression levels of Atg5, Beclin1, LC3, Cav1 and Cav2 were detected by immunofluorescence staining, qRT-PCR and Western-blot.ResultsEGF inhibited autophagy in yak cumulus cells by down-regulating the expression of Atg5, Beclin1, and LC3. The level of autophagy varied with the concentration of ligands, and the inhibition was most significant at 100 ng/mL. Noteworthy, EGF can promote endocytosis by regulating the expression of Cav1 and Cav2, but the EGFR-mediated signaling pathway is not the main way to regulate the expression of these proteins.DiscussionThese results provide a reference for further exploring the effects of growth factors on livestock germ cells and the regulatory role of autophagy-endocytosis crosstalk mechanism in follicle development and oocyte maturation, to improve the fecundity of yaks.
A Sustainable Method: Production of the Fermented Rice Milk Yogurt by Using Three Efficient Lactic Acid Bacteria
Authors: Hozzein Wael N. , Hisham Sameh M. , Alkhalifah Dalal Hussien M. 
Published: January 2023

Lactic acid bacteria (LAB) have long been used as starters in non-dairy cereal fermentation, as they aid in the production of products such as yoghurt and cheese. Broken rice milk is a plant-based milk alternative that is high in carbs and low in fat, providing excellent nutritional value to human users. The current study intends to ferment broken rice milk supplemented with 6% skim milk using three Lactobacillus strains for the development of yoghurt products, as well as to evaluate the growth, changes in physio-chemical properties, and sensory qualities of the yoghurt produced. Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus acidophilus, and a commercial yoghurt culture consortium fermented broken rice milk after 8 h. Rather than employing L. acidophilus or a commercial yogurt culture consortia, L. bulgarics was the most efficient starter for yoghurt manufacturing, followed by L. casei. L. bulgaricus had the highest viability counts of 8.5 Log CFU/mL, 0.18 specific growth rate, and 3.78 doubling time. Furthermore, it produces a significant reduction in pH to 4.3 and increases total titratable acidity to 0.09 percent with high overall acidity values of 1.4 mg/L of acetic and lactic acid contents. The maximum acidification rate (Vmax) was 0.2125, the maximum acidification time (Tmax) was 4 h, and the time to reach pH 4.6 (Te) was 5 to 8 h. As a result, L. bulgaricus was chosen as the most efficient isolate for the production of fermented rice milk yoghurt. More research is needed, however, to investigate the new rice-based yoghurt product’s sensory qualities as well as its toxicological effects on normal and malignant human cells.
Effect of Storage Time and Bacterial Strain on the Quality of Probiotic Goat’s Milk Using Different Types and Doses of Collagens
Authors: Szopa Kamil , Pawlos Małgorzata , Znamirowska-Piotrowska Agata 
Published: January 2023

Recently, increasing attention has been focused on developing new products based on goat’s milk. Consumers positively perceive fermented goat’s milk products as health-promoting due to their nutritional value, digestibility, and potential source of probiotics. This study aimed to evaluate the possibility of using different doses of collagen and collagen hydrolysate in the production of probiotic goat’s milk fermented by four monocultures: Lacticaseibacillus casei 431® Lactobacillus acidophilus LA- 5®, Lacticaseibacillus paracasei LP26, and Lacticaseibicillus rhamnosus Lr- 32®. A total of 20 experimental groups were prepared, including control groups (without additives), and due to the added probiotic (Lacticaseibacillus casei, Lactobacillus acidophilus, Lacticaseibacillus paracasei, and Lacticaseibacillus rhamnosus), various collagen doses (1.5% and 3.0%) and collagen types (hydrolysate and bovine collagen). Physicochemical, organoleptic, and microbiological characteristics were evaluated after 1 and 21 days of cold storage. The applied additives increased the acidity of the milk even before fermentation. However, milk with bovine collagen and hydrolysate had a higher pH value after fermentation than control milk. The study showed higher than 8 log cfu g−1 viability of probiotic bacteria in goat’s milk products during storage due to the proper pH, high buffering capacity, and rich nutrient content of goat’s milk. The best survival rate was shown for the L. casei strain after 21 days in milk with collagen protein hydrolysate. Moreover, collagen in milk fermented by L. rhamnosus decreased syneresis compared to its control counterpart. The addition of collagen, especially the hydrolysate, increased the gel hardness of the fermented milk. The collagen additives used in the milk, both in the form of hydrolysate and bovine collagen, caused a darkening of the color of the milk and increased the intensity of the milky-creamy and sweet taste.
Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected Mycoplasma pneumoniae Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene
Authors: Edelstein Inna Alexandrovna , Ivanova Olga Vladimirovna , Romashov Oleg Igorevich , Kozlov Roman Sergeevich 
Published: January 2023

We evaluated the effect of macrolide-resistant mutations in the Mycoplasma pneumoniae 23S rRNA gene on the severity of lower respiratory tract infections in immunocompetent young adults treated at the Smolensk Military Hospital between 25 October 2017, and 17 November 2021. All analyzed cases represented a non-severe infection of the lower respiratory tract: 44 case histories with community-acquired pneumonia and 20 cases with acute bronchitis. The presence of mutations in the gene 23S rRNA of M. pneumoniae was determined with standard Sanger sequencing. The macrolide-resistant genotype was found in 4/44 (9.1%) of the samples of the patients with pneumonia and in 3/20 (15%) of the samples of the patients with acute bronchitis. The analyzed cases with identified M. pneumoniae carrying a mutation in the 23S rRNA gene did not show any differences in the clinical presentation in terms of disease severity caused by M. pneumoniae with the wild-type (WT) phenotype.
Variations in Yield, Essential Oil, and Salicylates of Filipendula ulmaria Inflorescences at Different Blooming Stages
Authors: Ložienė Kristina , Būdienė Jurga , Vaitiekūnaitė Urtė , Pašakinskienė Izolda 
Published: January 2023

Meadowsweet (Filipendula ulmaria) is an essential oil-bearing, pharmacologically valuable medicinal plant growing wild in floodlands that are either not usually used for agriculture or have low economic value. The aim of this work was to understand the relationship between the yield of F. ulmaria inflorescences and the qualitative and quantitative composition of the essential oil during flowering stages in different habitats. Five different habitats of F. ulmaria were investigated for evaluation of inflorescence characteristics (length and weight) and the quantitative and qualitative composition of essential oils in early and late blooming stages (growing stage BBCH 62–63 and BBCH 65–67/72–73, respectively). The results showed significant (p < 0.05) positive correlations between the length and weight of inflorescences both in early and in late blooming stages (r = 0.73 and r = 0.72, respectively). The early blooming stage was observed to have 1.2–2 times greater quantity of volatile oils in comparison with the late blooming stage. Salicylaldehyde and methylsalicylate were the main salicylates in both blooming stages. Spearman’s correlation showed statistically significant relationship between percentages of salicylaldehyde and methylsalicylate (r = −0.94, p < 0.05). An increase in salicylaldehyde was accompanied by a decrease in methylsalicylate in essential oils. Statistically significant relations between the investigated parameters of plant and the parameters of habitat were not detected. The dried raw material yield of F. ulmaria in 1 ha in the late blooming stage was 18–56% higher than in the early blooming stage; however, the yield of essential oil in the early flowering stage was 1.5–1.6 times higher than in the late flowering stage. The obtained research data suggest that the low economic value of floodlands—the habitats of F. ulmaria—can be increased by using these areas as natural industrial plots.