bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disability-Adjusted Life Expectancy and Cognitive Function among Community-Dwelling Adults
Authors: Nam Sanghun , Downer Brian , Cha Suna , Choi Jae-Sung , Yang Seungmin , Hong Ickpyo 
Published: May 2023

We aimed to calculate disability-adjusted life expectancy (DALE) for Korean older adults based on their sex, educational attainment, and residential region across their cognitive status. We included 3,854 participants (aged 65–91 years) from the Korean Longitudinal Study of Aging’s seventh survey data. The participant’s cognitive function status (normal, moderately impaired, or severely impaired) was determined based on cognitive examination and physical function independence, which was used to calculate their DALE. Females with normal cognition had higher DALE (7.60 years, Standard Deviation (SD) = 3.88) than males (6.76, SD = 3.40); however, both sexes had comparable DALE for cognitive impairment. In contrast, the DALE values increased with higher educational achievements. Regarding residential areas, the DALE value for participants with normal cognition and moderate impairment was the highest among urban dwellers, while DALE for participants with severely impaired cognitive function was highest among rural dwellers; however, there were no statistically significant differences based on residential conditions. Our findings suggest that demographic characteristics should be considered when developing health policies and treatment strategies to meet the needs of the aging population in Korea.
Younger, drunk, and fast: Paradoxical rapid reaction time in hazardous drinkers
Authors: Powell Anna , Sumnall Harry , Montgomery Catharine 
Published: May 2023

Background: Research consistently links hazardous alcohol use with reduced cognitive function but is less consistent with regard to processing speed, which underpins many cognitive functions. Using vibrotactile perception to assess cognitive function may have benefits over other sensory stimuli, as this method gives lower variability in reaction time (RT) and shorter latency. Aims: This study aimed to assess performance on vibrotactile simple and choice RT tasks between hazardous and non-hazardous drinkers. Methods: Participants ( n = 86) completed vibrotactile tasks and alcohol, mood and subjective function (Executive Function Index (EFI)) questionnaires. Multivariate analyses of covariance were performed on average RT scores, and on EFI scores, to investigate function, and a bivariate correlation assessed the relationships between subjective and objective measures. Results: Hazardous drinkers exhibited significantly faster choice RT. With regard to subjective executive function, Strategic Planning and Impulse Control were significantly better in non-hazardous drinkers. Finally, Organisation and Impulse Control both significantly positively correlated with choice and simple RT, indicating that as subjective function improved, RT increased (a decline in performance). Conclusions: These results are considered in the context of the premature ageing hypothesis, impulsivity and the impact of alcohol use on various neurotransmitter systems. Furthermore, the poorer subjective function in young hazardous drinkers indicates a possible metacognitive deficit, increased effort or issues with vibrotactile perception as a cognitive function assessment in this group.
‘Recreational shaming groups of Facebook: Content, rules and modministrators’ perspectives’
Authors: Murumaa-Mengel Maria , Lott Kaarel 
Published: May 2023

As social life and communication move increasingly online, we have experienced the expansion and the normalisation of online shaming – different forms of (semi)public cross-platform condemnation of people and their actions by (mass) online audiences. Online shamings can be analysed as combinations of reintegrative (shame-correct-forgive) and disintegrative (shame-stigmatise-expel) social sanctioning practices, usually focusing the ‘serious’ disciplinary shaming on the behaviour of the offender. We propose that equal attention should be given to what we have termed ‘recreational shaming’ – humour-based playful collective shaming that often occurs via online platforms, seemingly just for the sake of shaming, motivated mainly by social belonging needs and entertainment gratification. By combining the results of standardised content analysis of Facebook recreational shaming groups ( n = 65) and in-depth qualitative interviews with the ‘modmins’ of the groups ( n = 8) we will give an overview of what is being shamed, how groups and modministrators create and enforce rules and what is the socio-cultural perceived meaning of this practice. We distinguish three spheres of recreational shaming that ‘frame the shame’ and demonstrate how recreational online shaming is often more about the self than the other – me performing the act of shaming for entertainment value, to belong in a group. Additionally, we introduce how shaming is used as a self-reflexive tool for behaviour-correction or base knowledge for dominant tastes.
Multidisciplinary coordination of care for children with esophageal atresia and tracheoesophageal fistula
Authors: Platt Jody M , Nettel-Aguirre Alberto , Bjornson Candice L , Mitchell Ian , Davis Kathryn , Bailey JA Michelle 
Published: May 2023

Esophageal Atresia/Tracheoesophageal Atresia (EA/TEF) is a multisystem congenital anomaly. Historically, children with EA/TEF lack coordinated care. A multidisciplinary clinic was established in 2005 to provide coordinated care and improve access to outpatient care. This single-center retrospective cohort study was conducted to describe our cohort of patients with EA/TEF born between March 2005 and March 2011, assess coordination of care, and to compare outcomes of children in the multidisciplinary clinic to the previous cohort without a multi-disciplinary clinic. A chart review identified demographics, hospitalizations, emergency visits, clinic visits, and coordination of outpatient care. Twenty-seven patients were included; 75.9% had a C-type EA/TEF. Clinics provided multidisciplinary care and compliance with the visit schedule was high with a median of 100% (IQR 50). Compared to the earlier cohort, the new cohort ( N = 27) had fewer hospital admissions and LOS was reduced significantly in the first 2 years of life. Multidisciplinary care clinics for medically complex children can improve coordination of visits with multiple health care providers and may contribute to reduced use of acute care services.
Long-Term Outcome of Intact Abdominal Aortic Aneurysm After Endovascular or Open Repair
Authors: Epple Jasmin , Svidlova Yuliya , Schmitz-Rixen Thomas , Böckler Dittmar , Lingwal Neelam , Grundmann Reinhart T. ,   on behalf of the German Institute for Vascular Healthcare Research (DIGG) of the German Society for Vascular Surgery and Vascular Medicine
Published: May 2023

Objective Endovascular aortic aneurysm repair (EVAR) has been established as a standard treatment option for intact abdominal aortic aneurysm (iAAA) and gained importance due to a lower perioperative mortality than open repair (OAR). However, whether this survival advantage can be maintained or if OAR is beneficial in terms of long-term complications and reinterventions remains questionable. Design In this retrospective cohort study data from patients undergoing elective EVAR or OAR for iAAAs in the years 2010-2016 was analyzed. The patients were followed through 2018. Methods In the propensity score matched cohorts the perioperative and long-term outcomes of the patients were assessed. We identified 20 683 patients undergoing elective iAAA repair (76.4% EVAR). The propensity matched cohorts included 4886 pairs of patients. Results The perioperative mortality was 1.9% for EVAR and 5.9% for OAR ( P = <.001). The perioperative mortality was mainly influenced by patients age (Odds-Ratio (OR):1.073, confidence interval (CI):1.058-1.088, P ≤ .001) and OAR (OR:3.242, CI:2.552-4.119, P ≤ .001). The early survival benefit after endovascular repair persisted for approximately 3 years (estimated survival EVAR 82.3%, OAR 80.9%, P = .021). After that time the estimated survival curves were similar. After 9 years the estimated survival was 51.2% after EVAR as compared to 52.8% after OAR ( P = .102). The operation method didn’t influence long-term survival significantly (Hazard-Ratio (HR): 1.046, CI: .975-1.122, P = .211). The vascular reintervention rate was 17.4% in the EVAR cohort and 7.1% in the OAR cohort ( P ≤ .001). Conclusion EVAR has a significantly lower perioperative mortality than OAR, a survival benefit that lasts up to 3 years after intervention. Thereafter, no significant difference in survival was observed between EVAR and OAR. The decision between EVAR or OAR may depend on patient preference, surgeons’ experience, and the institutions’ ability to handle complications.
Continental weathering as the source of iron in Jurassic iron oolites from Switzerland
Authors: Schunck Stefan , Rickli Jörg , Wohlwend Stephan , Weissert Helmut , Vance Derek 
Published: May 2023

AbstractIron is extremely insoluble in oxic seawater. The lack of a large aqueous reservoir means that sediments rich in authigenic iron are rare in the modern ocean. In the Middle Jurassic, however, condensed iron-rich sedimentary rocks are widely distributed. Their formation coincides with increased volcanic activity and continental weathering related to the breakup of Pangea, suggesting iron supply through one of these processes. We studied three Swiss shallow-marine iron oolites from Herznach, Windgällen and Erzegg, all from condensed sedimentary sequences of Middle to early Late Jurassic age, to constrain the source of iron to these rocks, combining radiogenic neodymium, strontium and stable iron isotope analyses. Leached authigenic neodymium isotope compositions, which appear to preserve the primary signature, serve as a tracer for the potential involvement of hydrothermal fluids in the formation of the iron oolites. The three iron oolite successions yield crustal Nd isotope compositions (εNd between − 9 and − 7), providing no evidence for the involvement of such fluids. It is, thus, more likely that iron in the sediments derived from detrital fluvial inputs. Strontium isotope compositions, which could potentially support these findings, point to metamorphic overprinting associated with Alpine thrusting. The light iron isotope signatures associated with Middle to early Late Jurassic condensed sequences, δ56Fe between − 1.49 and − 0.57‰, suggest that microbially-mediated iron reduction was also involved in generating these sediments.
From freshwater inflows to salt lakes and salt deposits in the Qaidam Basin, W China
Authors: Stober I. , Zhong J. , Bucher K. 
Published: May 2023

AbstractThe Qaidam basin in W China is an immense hyperarid intramontane basin with flat vast playas and salt lakes on the Qinghai-Tibet Plateau. The central basin is about 2800–2900 m a.s.l. elevation and enclosed by mountain ranges reaching > 5800 m in the Qilian Mountains and > 6200 m in the eastern Kunlun Mountains. The extensive playas of the basin are covered by gypsum or halite with very subordinate additional solids. In this contribution we report on the chemical composition of salt lakes and inflows to the Qaidam basin (analysis of 30 water samples collected in the summer of 2008 and 2009) together with the composition of 22 salt samples. Salt lakes and small salt ponds formed at topographic depressions. Some of the lakes cover > 300 km2 surface but are very shallow (1–2 m deep). Most salt lakes and salt ponds are NaCl dominated and contain typically 250–300 g kg−1 total dissolved solids (TDS). Some lakes are industrially used and produce KCl fertilizer, LiCl, and boron or are strongly modified by deep water produced in oil fields. Lakes along the borders to the high mountains are typically not fully saturated with halite. However, also these lakes lost most Ca and are drastically enriched in Mg and some lakes also in B and Li. The chemical development of the most natural salt lakes follows a path producing Ca-deficient water that ultimately precipitate Mg-bearing carbonates and chlorites in addition to halite upon evaporation. The salt lakes form by continuous and drastic evaporation of the waters supplied by the inflows to the lakes in the basin. All inflows carry considerable amounts of Cl and are characterized by very high Cl/Br ratios. These chemical characteristics suggest that the salt load of the inflows originates mostly from re-dissolved windblown halite deposited together with sand up to high altitudes in the bordering mountain ranges. Also, thermal waters ascending along deep faults along the Qilian Mountains carry considerable amounts of chloride. Their low Cl/Br ratio however suggests that most of the dissolved Na is derived from minerals of the basement rocks by fluid-rock interaction at T > 130 °C. The thermal fluids also carry considerable amounts of boron, indicating that co-precipitated borax in the salt lakes ultimately also derives from minerals in the basement rocks (tourmaline). Consequently, the presented data improve the understanding how the brines and salt lake waters develop from a wide range of chemically distinct low-TDS inflows and how the sequences of minerals precipitated upon evaporation in the Qaidam basin formed.
Plasma-derived small extracellular vesicles unleash the angiogenic potential in head and neck cancer patients
Authors: Tengler Luisa , Schütz Julia , Tiedtke Moritz , Jablonska Jadwiga , Theodoraki Marie-Nicole , Nitschke Katja , Weiß Christel , Seiz Elena , Affolter Annette , Jungbauer Frederic , Lammert Anne , Rotter Nicole , Ludwig Sonja 
Published: May 2023

Abstract
Background
In Head and neck cancer (HNC) angiogenesis is essential for tumor progression and metastasis. Small extracellular vesicles (sEVs) from HNC cell lines alter endothelial cell (EC) functions towards a pro-angiogenic phenotype. However, the role of plasma sEVs retrieved from HNC patients in this process is not clear so far.

Methods
Plasma sEVs were isolated on size exclusion chromatography columns from 32 HNC patients (early-stage UICC I/II: 8, advanced-stage UICC III/IV: 24), 12 patients with no evident disease after therapy (NED) and 16 healthy donors (HD). Briefly, sEVs were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), BCA protein assays and Western blots. Levels of angiogenesis-associated proteins were determined using antibody arrays. The interaction of fluorescently-labeled sEVs with human umbilical vein ECs was visualized by confocal microscopy. The functional effect of sEVs on tubulogenesis, migration, proliferation and apoptosis of ECs was assessed.

Results
The internalization of sEVs by ECs was visualized using confocal microscopy. Based on antibody arrays, all plasma sEVs were enriched in anti-angiogenic proteins. HNC sEVs contained more pro-angiogenic MMP-9 and anti-angiogenic proteins (Serpin F1) than HD sEVs. Interestingly, a strong inhibition of EC function was observed for sEVs from early-stage HNC, NED and HD. In contrast, sEVs from advanced-stage HNC showed a significantly increased tubulogenesis, migration and proliferation and induced less apoptosis in ECs than sEVs from HD.

Conclusions
In general, plasma sEVs carry a predominantly anti-angiogenic protein cargo and suppress the angiogenic properties of ECs, while sEVs from (advanced-stage) HNC patients induce angiogenesis compared to HD sEVs. Thus, tumor-derived sEVs within the plasma of HNC patients might shift the angiogenic switch towards angiogenesis.
Probiotic candidates for controlling Paenibacillus larvae, a causative agent of American foulbrood disease in honey bee
Authors: Truong A-Tai , Kang Jeong Eun , Yoo Mi-Sun , Nguyen Thi Thu , Youn So-Youn , Yoon Soon-Seek , Cho Yun Sang 
Published: May 2023

Abstract
Background
American foulbrood (AFB) disease caused by Paenibacillus larvae is dangerous, and threatens beekeeping. The eco-friendly treatment method using probiotics is expected to be the prospective method for controlling this pathogen in honey bees. Therefore, this study investigated the bacterial species that have antimicrobial activity against P. larvae.

Results
Overall, 67 strains of the gut microbiome were isolated and identified in three phyla; the isolates had the following prevalence rates: Firmicutes 41/67 (61.19%), Actinobacteria 24/67 (35.82%), and Proteobacteria 2/67 (2.99%). Antimicrobial properties against P. larvae on agar plates were seen in 20 isolates of the genus Lactobacillus, Firmicutes phylum. Six representative strains from each species (L. apis HSY8_B25, L. panisapium PKH2_L3, L. melliventris HSY3_B5, L. kimbladii AHS3_B36, L. kullabergensis OMG2_B25, and L. mellis OMG2_B33) with the largest inhibition zones on agar plates were selected for in vitro larvae rearing challenges. The results showed that three isolates (L. apis HSY8_B25, L. panisapium PKH2_L3, and L. melliventris HSY3_B5) had the potential to be probiotic candidates with the properties of safety to larvae, inhibition against P. larvae in infected larvae, and high adhesion ability.

Conclusions
Overall, 20 strains of the genus Lactobacillus with antimicrobial properties against P. larvae were identified in this study. Three representative strains from different species (L. apis HSY8_B25, L. panisapium PKH2_L3, and L. melliventris HSY3_B5) were evaluated to be potential probiotic candidates and were selected for probiotic development for the prevention of AFB. Importantly, the species L. panisapium isolated from larvae was identified with antimicrobial activity for the first time in this study.
Pregnancy outcomes of intrauterine insemination without ovarian stimulation in couples affected by unilateral tubal occlusion and male infertility
Authors: Tang Yan , He Yu-Xia , Ye Yun , Zhang Ting-Ting , Wang Jing-Jing , He Qian-Dong 
Published: May 2023

Abstract
Background
Information available to date regarding the pregnancy outcomes of intrauterine insemination (IUI) without ovarian stimulation (OS) in infertile patients with unilateral tubal occlusion remains scarce. The objectives of this study were to investigate for couples affected by unilateral tubal occlusion (diagnosed via hysterosalpingography (HSG)/transvaginal real-time three-dimensional hysterosalpingo-contrast sonography (TVS RT-3D-HyCoSy)) and male infertility: (1) whether significant differences exist in pregnancy outcomes between IUI with or without OS cycles, and (2) whether the pregnancy outcomes of IUI without OS in women with unilateral tubal occlusion were similar to those of women with bilateral patent tubes.

Methods
258 couples affected by male infertility completed 399 IUI cycles. The cycles were divided into three groups: group A, IUI without OS in women with unilateral tubal occlusion; group B, IUI with OS in women with unilateral tubal occlusion; and group C, IUI without OS in women with bilateral patent tubes. The main outcome measures, including clinical pregnancy rate (CPR), live birth rate (LBR), and first trimester miscarriage rate, were compared between either groups A and B or groups A and C.

Results
Although the number of dominant follicles > 16 mm were significantly higher in group B than that in group A (group B vs. group A: 1.6 ± 0.6 vs. 1.0 ± 0.2, P < 0.001), the CPR, LBR, and first trimester miscarriage rate were comparable between these two groups. When comparing group C to group A, the duration of infertility was significantly longer in group C than that in group A (group A vs. group C: 2.3 ± 1.2 (year) vs. 2.9 ± 2.1 (year), P = 0.017). Except for the first trimester miscarriage rate, which was significantly higher in group A (42.9%, 3/7) than that in group C (7.1%, 2/28) (P = 0.044), no significant differences were observed in the CPR and LBR in these two groups. After adjusting for female age, body mass index, and the duration of infertility, similar results were obtained between groups A and C.

Conclusions
In couples affected by unilateral tubal occlusion (diagnosed via HSG/TVS RT-3D-HyCoSy) and male infertility, IUI without OS might be an alternative treatment strategy. However, when compared to patients with bilateral patent tubes, the patients with unilateral tubal occlusion showed a higher first trimester miscarriage rate following IUI without OS cycles. Further studies are warranted to clarify this relationship.
Concealed pregnancy as an act of care? A qualitative analysis of motivations for concealing and non-disclosure of early pregnancy in The Gambia
Authors: Parrish Sabine , Vasan Senthil K. , Karpe Fredrik , Hardy-Johnson Polly , Jarjou Ousman , Bittaye Mustapha , Prentice Andrew M. , Ulijaszek Stanley , Jobe Modou 
Published: May 2023

AbstractBackgroundA barrier to achieving first trimester antenatal care (ANC) attendance in many countries has been the widespread cultural practice of not discussing pregnancies in the early stages. Motivations for concealing pregnancy bear further study, as the interventions necessary to encourage early ANC attendance may be more complicated than targeting infrastructural barriers to ANC attendance such as transportation, time, and cost.MethodsFive focus groups with a total of 30 married, pregnant women were conducted to assess the feasibility of conducting a randomised controlled trial to evaluate the effectiveness of early initiation of physical activity and/or yoghurt consumption in reducing Gestational Diabetes Mellitus in pregnant women in The Gambia. Focus group transcripts were coded through a thematic analysis approach, assessing themes as they arose in relation to failure to attend early ANC.ResultsTwo reasons for the concealment of pregnancies in the first trimester or ahead of a pregnancy’s obvious visibility to others were given by focus group participants. These were ‘pregnancy outside of marriage’ and ‘evil spirits and miscarriage.’ Concealment on both grounds was motivated through specific worries and fears. In the case of a pregnancy outside of marriage, this was worry over social stigma and shame. Evil spirits were widely considered to be a cause of early miscarriage, and as such, women may choose to conceal their pregnancies in the early stages as a form of protection.ConclusionWomen’s lived experiences of evil spirits have been under-explored in qualitative health research as they relate specifically to women’s access to early antenatal care. Better understanding of how such sprits are experienced and why some women perceive themselves as vulnerable to related spiritual attacks may help healthcare workers or community health workers to identify in a timely manner the women most likely to fear such situations and spirits and subsequently conceal their pregnancies.