bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting community and structural hole spanner for influence maximization in social networks
Authors: Li Xiao , Chen Ziang 
Published: September 2023

AbstractViral marketing is a frequently used social marketing strategy which aims to promote products on various social media. In order to devise an efficient viral marketing strategy, influence maximization problem is widely studied in social networks. Influence maximization problem tries to find a set of influential users who could influence social users maximally. However, existed influence maximization algorithms could not satisfy the needs of social marketers well. In social networks, community structure is an important feature where social users are closely connected together in groups, and structural hole spanners are those users who bridge different communities. In order to balance the effectiveness and efficiency of viral marketing in social networks, in this paper, we present to exploit the community structure and structural hole spanners in social networks for solving the influence maximization problem. Different to traditional algorithms, we devise a strategy to approximate social influences of social users to find seeds efficiently. In particular, for an internal user inside a community in social networks, we utilize his social influence to members inside this community to approximate his social influence in the whole social network. For a structural hole spanner who bridges multiple communities, we utilize his social influence to members in these communities to approximate his social influence in the whole network. Based on the approximate social influence, information diffusion model and greedy framework, we propose a Community and Structural Hole Spanner based Greedy (CSHS‐G) algorithm which devises several influence lists to store social influences of users and fast computation scheme to find seeds. Besides, to further improve the efficiency, we propose a Community and Structural Hole Spanner based Heuristic (CSHS‐H) algorithm which approximates social influences of structural hole spanners by utilizing their 2‐hops influences. We conduct a comprehensive performance evaluation on the crawled real‐world data set. Experimental results show that, compared to all of the baseline algorithms, our proposed algorithms not only have high efficiency, but also could guarantee larger influence spread.
RKV01 Rutile – A New Potential Archaean Reference Material for Microbeam U‐Pb Dating
Authors: Huang Chao , Wang Hao , Yang Jin‐Hui , Kamo Sandra L. , Tu Jia‐Run , Hou Zhen‐Hui , Zhang Le , Yang Yue‐Heng , Xie Lie‐Wen , Wu Shi‐Tou , Xu Lei 
Published: September 2023

Rutile stands as a classical mineral within U‐Pb geochronology, offering insights into both magmatic and metamorphic events, and contributing to the understanding of provenance of detrital sedimentary rocks. Addressing the paucity of high‐quality Archaean rutile reference materials suitable for microbeam U‐Pb dating, we present a natural rutile (RKV01) sourced from the Kaap Valley pluton, South Africa, positing it as a potential Archaean reference material. Major element determination was executed via electron probe microanalysis, while trace element determination was conducted using laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS). The determination of U‐Pb ages involved the application of isotope dilution‐thermal ionisation mass spectrometry (ID‐TIMS), secondary ion mass spectrometry (SIMS) and LA‐ICP‐MS. The ID‐TIMS mean 207Pb/206Pb age is 3225.61 ± 0.64 Ma (2s, MSWD = 0.83), interpreted as the best estimate for the crystallisation age. The relatively high U mass fraction (~ 83 μg g‐1), extremely low Th mass fraction (~ 0.003 μg g‐1), negligible common Pb and isotopically homogeneous compositions collectively facilitated precise 207Pb/206Pb age determination via microbeam methods. Both LA‐ICP‐MS and SIMS 207Pb/206Pb ages are characterised by reproducibility and were consistent with the ID‐TIMS age within 2s analytical uncertainty. The results underscore the potential of RKV01 rutile as an Archaean reference material for microbeam U‐Pb dating.
Cases of less‐than‐expected FVIII activity in previously treated patients during post‐marketing surveillance of N8‐GP
Authors: Oldenburg Johannes , Benson Gary , Chowdary Pratima , Halimeh Susan , Matsushita Tadashi , Nørland Anne , Wahid Mohd Nawi , Nemes Laszlo 
Published: September 2023

AbstractIntroductionTuroctocog alfa pegol (N8‐GP) is a glycoPEGylated, extended half‐life (EHL), human recombinant factor VIII (FVIII) approved for the treatment and prevention of bleeding episodes in patients with haemophilia A. Since its launch in August 2019, > 800 patients have been treated worldwide.AimTo present data from identified post‐marketing cases of less‐than‐expected FVIII activity in previously treated patients (PTPs) without inhibitors after switching to N8‐GP.MethodsThe post‐marketing safety database was searched using keywords such as ‘coagulation FVIII level decreased’. Identified cases reported prior to 13 October 2021 were included in this report. Cases in which patients had FVIII inhibitors were excluded.ResultsHere we report 14 cases of less‐than‐expected FVIII activity. Details varied greatly amongst the cases. At presentation, FVIII activity ranged from 1% (15 min post‐dose) to 51% (2 days post‐dose). Seven patients experienced bleeding episodes after switching to N8‐GP with heterogeneity in bleeding presentations. Six out of seven patients who were tested for anti‐PEG IgG and/or IgM antibodies were positive. In all known cases, FVIII activity returned to the expected range when switched to an alternative FVIII replacement product.ConclusionIn conclusion, the 14 reported cases of less‐than‐expected FVIII activity, without presence of detectable FVIII inhibitors, presented with heterogenous characteristics, and wide variations in FVIII activity and anti‐PEG antibody titre. FVIII activity returned to the expected range after switching to alternative FVIII products. In line with WFH guidelines, monitoring of FVIII activity can ensure FVIII activity in the expected range. The safety surveillance of N8‐GP continues.
Does the method of telehealth delivery affect the physiotherapy management of adults with bleeding disorders? A comparison of audioconferencing and videoconferencing
Authors: Russell Scott , Whitehart Simon , Mason Jane , Window Peter 
Published: September 2023

AbstractAimTo determine whether the method of telehealth delivery (audioconferencing or videoconferencing) affects the physiotherapy management of adults with inherited bleeding disorders.MethodsA cross‐sectional observational study was utilised involving 40 physiotherapy consultations (23 initial consultations and 17 follow‐up consultations) of adults (>18) with a diagnosed bleeding disorder. Each consultation involved an initial audioconferencing component followed immediately by a separate videoconferencing component. Following each component, the physiotherapist utilised the clinical information gathered to formulate and record a management plan, and additionally recorded their confidence in this plan. Differences between the management plans and clinician confidence were recorded, including where applicable the visual information prompting a change in management plans.ResultsAudioconferencing and videoconferencing management plans differed in 40% of all consultations, including 52.0% of initial consultations and 23.5% of follow‐up consultations. Among consultations where management plans differed, this was prompted by visual information related to the anatomic location of symptoms (31.3%), the absence/presence of swelling (31.3%), joint range of movement (25.0%), and general appearance (12.5%). Median self‐reported clinician confidence of management plans increased significantly from 70.0% following audioconferencing to 93.0% following videoconferencing.ConclusionWhen utilizing telehealth, the choice between audioconferencing or videoconferencing may affect physiotherapy management of adults with bleeding disorders, particularly with initial consultations. Videoconferencing potentially leads to more appropriate management plans, clinician confidence and utilization of healthcare resources. Further high‐quality studies are required to confirm the findings of this study.
‘Implanted in us by Nature’: The Cognitive Science of Religion and its Importance for Theology
Authors: Gornandt Ruth 
Published: September 2023

AbstractAbstract: The Cognitive Science of Religion (CSR) holds that religion emerges from human cognition and its intuitions. Hence, it describes religion as a ‘natural’ belief in ‘supernatural agents’. Traditional theology also maintained that there is an ‘innate’ or ‘implanted’ knowledge of God or gods. It will be argued that CSR and theology can be related, yet not in a straightforward manner. After sketching out in what sense CSR calls religion ‘natural’ and how it describes ‘supernatural agents’, this article explores some examples of the traditional theological doctrine of an ‘implanted’ knowledge of God. It shows that the reliability of such an ‘implanted’ knowledge of God was disputed among theologians and, even if it was affirmed, had an ambiguous position in theology. This also applies to CSR if it is to be related to the traditional theological doctrine. There are illuminating convergences between CSR and theology but also considerable divergences. Both, however, prove significant for theology.
High‐grade vulvar intraepithelial neoplasia: comprehensive characterization and long‐term vulvar carcinoma risk
Authors: Thuijs Nikki B , van Beurden Marc , Duin Sylvia , Heideman Daniëlle A M , Berkhof Johannes , Steenbergen Renske D M , Bleeker Maaike C G 
Published: September 2023

AimsAdequate diagnosis of human papillomavirus (HPV)‐associated high‐grade squamous intraepithelial lesion (HSIL) and HPV‐independent vulvar intraepithelial neoplasia (VIN) is essential but can be challenging. We comprehensively characterized a large population‐based series of vulvar lesions, originally reported as high‐grade VIN, and assessed the cancer risk.Methods and resultsBaseline high‐grade VIN of 751 patients were categorized by histopathological reassessment, integrating the results of immunohistochemistry (p16INK4a, p53, Ki‐67) and HPV DNA testing. Integrated analyses resulted in 88.4% HPV‐associated lesions (77.0% HSIL, 10.9% low‐grade SIL [LSIL], and 0.4% vulvar squamous cell carcinoma [VSCC]), 10.9% HPV‐independent lesions (6.1% HPV‐independent VIN, 4.7% nondysplastic lesions, and 0.1% VSCC) and 1.1% inconclusive lesions. HSIL demonstrated p16INK4a block‐positivity in 99.0%, increased Ki‐67 in ≥2/3rd of the epithelium in 93.6%, and HPV positivity in 99.6%. In HSIL, a p53 wildtype mid‐epithelial staining pattern was common (51.6%) while this was not observed in HPV‐independent lesions. HPV‐independent VIN harboured mutant p53 patterns in 65.2% and showed a wide morphological spectrum, ranging from differentiated to nondifferentiated (‘HPV‐associated‐like’, in 41.3%). Kaplan–Meier analyses showed a 10‐year cancer risk of 8.0% in HPV‐associated HSIL, 67.4% in HPV‐independent VIN/p53mutant, and 27.8% in HPV‐independent VIN/p53wildtype. Strikingly, the 10‐year cancer risk was 73.3% in HPV‐independent VIN with nondifferentiated (‘HPV‐associated‐like’) morphology.ConclusionImmunohistochemistry by p16INK4a and p53 is highly recommended for optimal categorization into HPV‐associated and HPV‐independent VIN, which is of utmost importance given the different cancer risk. The high cancer risk of HPV‐independent VIN underscores the need for surgical treatment and close follow‐up, especially in case of a p53 mutant pattern and/or nondifferentiated morphology.
Recent insights on the clinical, pathological, and molecular features of intraductal carcinoma of the prostate
Authors: Naito Yushi , Kato Masashi , Nagayama Jun , Sano Yuta , Matsuo Kazuna , Inoue Satoshi , Sano Tomoyasu , Ishida Shohei , Matsukawa Yoshihisa , Tsuzuki Toyonori , Akamatsu Shusuke 
Published: September 2023

AbstractIntraductal carcinoma of the prostate, a unique histopathologic entity that is often observed (especially in advanced prostate cancer), is characterized by the proliferation of malignant cells within normal acini or ducts surrounded by a basement membrane. Intraductal carcinoma of the prostate is almost invariably associated with an adjacent high‐grade carcinoma and is occasionally observed as an isolated subtype. Intraductal carcinoma of the prostate has been demonstrated to be an independent poor prognostic factor for all stages of cancer, whether localized, de novo metastatic, or castration‐resistant. It also has a characteristic genetic profile, including high genomic instability. Recognizing and differentiating it from other pathologies is therefore important in patient management, and morphological diagnostic criteria for intraductal carcinoma of the prostate have been established. This review summarizes and outlines the clinical and pathological features, differential diagnosis, molecular aspects, and management of intraductal carcinoma of the prostate, as described in previous studies. We also present a discussion and future perspectives regarding intraductal carcinoma of the prostate.
Evidence of tactile arm stepping in newborns and its responsiveness to optic flows specifying self‐translation
Authors: Barbu‐Roth Marianne , Anderson David I. 
Published: September 2023

AbstractAlthough the arms participate in many forms of human locomotion, we know very little about when arm movements emerge during locomotor development. Here we investigated whether newborns would make tactile arm stepping movements when we supported them almost horizontally so their hands touched a surface and blocked their leg movements. Building off prior work showing that newborns make more crawling and air stepping leg movements when exposed to optic flows specifying forward and backward self‐translation, we also examined whether newborns would make more tactile arm steps when exposed to forward and backward optic flows compared to a random optic flow that did not specify translation. We found that newborns can perform arm stepping and produce a significantly higher number of tactile arm steps in the optic flow condition specifying backward translation than in the random optic flow condition. Both translating optic flow conditions had significantly higher numbers of alternating arm steps than the random optic flow condition. These findings show that tactile arm stepping exists at birth and that optic flows can facilitate their production, similar to leg stepping. We argue that these results further support the idea that a quadrupedal organization underlies early upright stepping.
The beneficial effects of transitional care for patients with stroke: A meta‐analysis
Authors: Saragih Ita Daryanti , Everard Gauthier , Saragih Ice Septriani , Lee Bih‐O 
Published: September 2023

AbstractIntroductionTransitional care interventions have emerged as a promising method of ensuring treatment continuity and health care coordination when patients are discharged from hospital to home. However, few studies have investigated the frequency and duration of interventions and the effects of interventions on physical function. Therefore, this study aimed to determine the efficacy of transitional care for patients with stroke.MethodsSix databases and the grey literature were searched to obtain relevant articles from October 1, 2022 to March 10, 2023. The primary outcomes studied were motor performance, walking speed, activities of daily living (ADLs) and caregiver burden following hospital‐to‐home transitional care. The quality of the studies was assessed with Cochrane risk of bias version 2. The quality and sensitivity of the evidence were assessed to ensure rigour of the findings. Meta‐analyses were performed using stata 17.0.ResultsA total of 2966 patients were identified from 23 studies. Transitional care improved post‐stroke motor performance, walking speed and ADLs, and reduced caregiver burden.ConclusionThe findings suggest that provision of transitional care model implementation in patients with stroke is important because it reduces disability in stroke patients and helps to decrease caregivers' burden.ImpactThe findings of the study emphasize the importance of transitional care programmes for stroke patients after they are discharged from the hospital and returned to their homes. To meet the needs of patients, all levels of health professionals including nurses should be aware of the discharge process and care plan.
Leveraging performance and feedback‐seeking indicators from a digital learning platform for early prediction of students' learning outcomes
Authors: Ober Teresa M. , Cheng Ying , Carter Matthew F. , Liu Cheng 
Published: September 2023

AbstractBackgroundStudents' tendencies to seek feedback are associated with improved learning. Yet, how soon this association becomes robust enough to make predictions about learning is not fully understood. Such knowledge has strong implications for early identification of students at‐risk for underachievement via digital learning platforms.ObjectivesWe sought to understand how early in the academic year students' end‐of‐year learning outcomes could be predicted by their performance and feedback‐seeking behaviours within a digital learning platform. We analysed data collected at different time points in the academic year and across different cohorts of students within the context of high school advanced placement (AP) Statistics courses.MethodsHigh school students enrolled in AP Statistics spanning three academic years between 2017 and 2020 (N = 726; Mage = 16.72 years) completed 3 or 4 homework assignments, each 2 and 3 months apart.Results and conclusionsAcross the three cohorts, and even as early as the first assignment, a model consisting of demographic variables (gender, race/ethnicity, parental education), assignment performance, and interaction with the digital score report explained significant variation in students' final course grades (R2 = 0.314–0.412) and AP exam scores (κ = 0.583–0.689). Students' assignment performance was positively associated with end‐of‐year learning outcomes. Students who more frequently checked their digital score reports tended to receive better learning outcomes, though not consistently across cohorts.ImplicationsThese findings further an understanding of how students' early performance and feedback‐seeking behaviours within a digital learning platform predict end‐of‐year learning outcomes.
Upregulation of FAM134B inhibits endoplasmic reticulum stress‐related degradation protein expression and promotes hepatocellular carcinogenesis
Authors: Wang Houhong , Liu Lu , Gong Huihui , Li Heng 
Published: September 2023

AbstractEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress‐related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. Construction of FAM134B knockdown cell line. Cell proliferation was measured using the CCK‐8 assay, while cell migration and invasion capabilities were detected using the plate colony formation assay. Flow cytometry was used to detect the apoptosis rate. Transmission electron microscopy was used to observe the formation of autophagosomes. qRT‐PCR and WB detective expression changes related to autophagy proteins. Finally, the expression of the relevant proteins was observed by immunohistochemistry. The expression of FAM134B was significantly increased in human liver cancer tissue and HCC cell lines Hep3B and Huh7. After the lentiviral vector was transfected into Hep3B cells with sh‐FAM134B, results showed that sh‐FAM134B could effectively inhibit Hep3B cell proliferation and promote HCC cell apoptosis. Meanwhile, sh‐FAM134B could effectively induce the autophagy of Hep3B liver cancer cells. Immunohistochemistry results showed that sh‐FAM134B could effectively induce ER stress. FAM134B inhibits HCC cell autophagy and promotes the progression of liver cancer by inhibiting the expression of ER stress‐related degradation factors such as DERL2, EDEM1, SEL1L and HRD1.
Using quantitative storytelling to identify constraints in resource supply: The case of brown seaweed
Authors: Ayala Maddalen , Thomsen Marianne , Pizzol Massimo 
Published: September 2023

AbstractSeaweed is increasingly considered a promising resource to produce high‐value products such as bioplastics due to potential environmental benefits such as carbon uptake and no land‐use change. However, the environmental assessment of emerging technologies for producing bioplastic from seaweed remains challenging due to the difficulties in modeling future seaweed supply and demand. Within the consequential approach to life cycle assessment, an increase in demand for seaweed is met by the marginal suppliers in the market: those that are not constrained in their capacity to increase supply in response to an increase in demand. Current methods to identify marginal suppliers are however based on quantitative information and do not consider qualitative aspects and uncertainties inherent in the study of emerging technologies. This study, therefore, proposes and tests the use of quantitative storytelling to identify marginal suppliers. The results show that there are two main groups of countries that are expected to be the marginal suppliers of brown seaweed for different reasons. Asian countries are currently the main brown seaweed suppliers and are expected to keep increasing and be marginal suppliers in the future. However, these countries have well‐established brown seaweed aquaculture and their growth is expected to be steady. On the other hand, brown seaweed suppliers in Northern Europe and North America are still emerging but are expected to grow faster in the future due to their production capacity and technological development.
The role of racial/ethnic discrimination in financial access and material hardship: Findings from Korean immigrants living in the deep south
Authors: Nam Yunju , Choi Eun Young , Won Cho Rong , Lee Hee Yun 
Published: September 2023

AbstractThis study examines how racial/ethnic discrimination influences financial access and material hardship, using survey data collected from self‐identified Korean immigrants living in two counties in Alabama (N = 241). Key variables are experiencing racial/ethnic discrimination, two subjective measures of financial access, and four indicators of material hardship (overall, food‐related, health insurance, and medical care). Descriptive analyses show a high rate of experiencing racial/ethnic discrimination, limited access to basic financial services and credit, and considerable rates of material hardship. Regression analyses indicate that experiencing discrimination has a significant association with access to credit but not with access to basic financial services. Access to credit has a significant and negative association with all types of material hardship. Our findings challenge the model minority myth of socially and economically integrated Asian/Korean immigrants. Results call for anti‐discrimination policies and public efforts to expand financial access and reduce material hardship among Korean immigrants.