bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of Escherichia coli Contamination in Vannameii Shrimp (Litopenaeus vannamei) using Cassava Leaf Extract (Manihot glaziovii) and Noni Fruit (Morinda citrifolia L.)
Authors: Chori Vina Asfia , Sartika Dewi , Hidayati Sri , S. Suharyono A. , Utomo Tanto P. 
Published: March 2023

This research is study of inhibition power between rubber cassava leaves extract (Manihot glaziovii) and noni (Morinda citrifolia l.) in reducing Eschericia coli contamination in vannameii shrimps (Litopenaeus vannamei). Cassava leaves contains flavonoids, saponins and tannins while noni contains antraquinone and scolopetin which has antimicrobial activity. This research aim at determine antimicrobial activity of cassava leaves extract and noni to inhibit Eschericia coli contamination in vannamei shrimps and determine the best formulation. The research use non-factorial complete randomized block design (RAKL) experimental design with three replications. The formulation in each treatment being used contained 25% (b/v) of the solvent. The treatments used in this study were M0S0 (control), M1S1 (25: 0), M2S2 (20: 5), M3S3 (15:10), M4S4 (10:15), M5S5 (5: 20), M6S6 (0:25) .Data were tested with the Barlett test and the Tuckey test to see the homogeneity. The data analysis was carried out using fingerprints to see the effect of treatment on the parameters being observed and followed with LSD test. The observations of research contained test of amount Eschericia Coli, Antimicrobial Inhibition, Eschericia coli Total Decrease, Antimicrobial Activity Application, pH test, and Sensory Testing (Color and Appearance). The results of this research showed that the extract of noni was more effective in inhibiting the contamination of Escherichia coli in vannamei shrimps with an inhibition zone of 7.23 mm compared to cassava leaves with an inhibition zone of 0.43 mm. The formulation has been obtained that the ratio between extracts of rubber cassava leaves and noni was 25%: 0% is best formulation to inhibit the microbial activity zwith the zone of inhibition is 7.23 mm. Keywords: Vannameii Shrimps, Rubber Cassava Leaves, Noni, Escherichia coli
Temperature and Humidity Monitoring in Dry Land of Cayene Pepper Based on Internet of Thing (IoT)
Authors: Widhiantari Ida Ayu , Sumarsono Joko , Annawawi M Abul Auni 
Published: March 2023

In general, plant growth will be disrupted if the environmental temperature is not suitable, even the plants will be damaged, which can cause a decrease in quality and quantity. Problems that often occur and are difficult to avoid include temperature and humidity conditions on agricultural land. Therefore it is necessary to do handling to be able to minimize the occurrence of damage that can occur in the land caused by environmental influences. This study aims to design a temperature and humidity monitoring system based on the Internet of Things (IoT). The research was carried out by designing electronic circuits from monitoring systems, hardware, software, and testing the systems that had been made. Technology supported by the use of DHT22 sensors can read temperature and humidity data in real time. Based on the research results, it was found that the DHT22 sensor used worked with the best accuracy on day 21 with an error percentage of 0% and the worst accuracy occurred on day 31 with an error percentage of 18.5%. Keywords: Internet of thing,Humidity,DHT22 Sensor,Air temperature.
The Performance of Pivot-Type Trailer for Fresh Fruit Bunches Transport Equipment Using Two-Wheeled Tractors in Oil Palm Fields
Authors: Idkham Muhammad Idkham , Dhafir Muhammad Dhafir , Safrizal Safrizal Safrizal 
Published: March 2023

Poor farmers in Indonesia still transport palm fruit bunches manually, so they require a lot of manpower and many of them are transported for a long time, reducing quality. Oil palm farmers have two-wheeled tractors that are used for processing rice fields that can be used for towing trailers. The existing conventional trailers do not work optimally in oil palm fields, so it is necessary to design a pivot type trailer. The purpose of this study was to see the performance of the pivot type trailer for transporting oil palm fruit bunches, the pivot type trailer and the conventional one that was tested directly on the farmers' oil palm fields involving 3 operators. The results show that the pivot type trailer has an advantage over conventional trailers and is easy to operate properly, this is reflected in its very small turning radius of 260 cm unloaded and 280 cm loaded, and has a larger working capacity.Keywords: Pivot type trailers, Conveyances, Oil palm fields, Oil palm bunches,Smallholders. Pivot type trailers, Conveyances, Oil palm fields, Oil palm bunches, Smallholders.
Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR
Authors: Smail Harem Othman , Mohamad Dlnya Asaad 
Published: March 2023

Abstract

Objective. Nowadays, type 2 diabetes mellitus (T2D) is the most common chronic endocrine disorder affecting an estimated 5–10% of adults worldwide, and this disease also rapidly increased among the population in the Kurdistan region. This research aims to identify DNA methylation change in the TCF7L2 gene as a possible predictive T2D biomarker.

Methods. One hundred and thirteen participants were divided into three groups: diabetic (47), prediabetic (36), and control (30). The study was carried out in patients who visited the private clinical sector between August and December 2021 in Koya city (Iraq Kurdistan region) to determine DNA methylation status using a methylation-specific PCR (MSP) with paired primers for each methylated and non-methylated region. In addition, the X2 Kruskal–Wallis statistical and Wilcoxon signed-rank tests were used, p<0.05 was considered significant.

Results. The results showed hypermethylation of DNA in the promoter region in diabetic and prediabetic groups compared to the healthy controls. Different factors affected the DNA methylation level, including body max index, alcohol consumption, family history, and physical activity with the positive Coronavirus.

Conclusion. The results obtained indicate that DNA methylation changes in the TCF7L2 promoter region may be used as a potential predictive biomarker of the T2D diagnosis. However, the findings obtained in this study should be supported by additional data.
Nutritional interventions for patients with alkaptonuria: A minireview
Authors: Imrich Richard , Zatkova Andrea , Lukacova Olga , Sedlakova Jana , Zanova Elizabeth , Vlcek Miroslav , Penesova Adela , Radikova Zofia , Havranova Andrea , Ranganath Lakshminarayan 
Published: March 2023

Abstract
Alkaptonuria (AKU, OMIM, No. 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from a deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to the accumulation of homogentisic acid (HGA) and subsequent deposition as pigment in connective tissues called ochronosis. As a result, severe arthropathy of large joints and spondyloarthropathy with frequent fractures, ligament ruptures, and osteoporosis develops in AKU patients. Since 2020, the first-time treatment with nitisinone has become available in the European Union. Nitisinone significantly reduces HGA production and arrests ochronosis in AKU patients. However, blocking of the tyrosine metabolic pathway by the drug leads to tyrosine plasma and tissue concentrations increase. The nitisinone-induced hypertyrosinemia can lead to the development of corneal keratopathy, and once it develops, the treatment needs to be interrupted. A decrease in overall protein intake reduces the risk of the keratopathy during nitisinone-induced hypertyrosinemia in AKU patients. The low-protein diet is not only poorly tolerated by patients, but over longer periods, leads to a severe muscle loss and weight gain due to increased energy intake from carbohydrates and fats. Therefore, the development of novel nutritional approaches is required to prevent the adverse events due to nitisinone-induced hypertyrosinemia and the negative impact on skeletal muscle metabolism in AKU patients.
Results of Survey and Evaluation of Invasive Plants in Ba Vi National Park, Vietnam
Authors: Tai Vu Anh , Thi Bich Hong Ngo , Thi Thuy Van Tran , Thi Kim Thoa Le 
Published: March 2023

The biodiversity of Ba Vi National Park has been faced with some passive impacts, one of them is alien species, that habitats for the native species is narrowed by increasing of invasive population expanding, it is necessary to conducted a research on the impacts of the invasive plants there and then giving the basis for better management of the national park. After field surveys in recently years (2018-2022), 47 alliance species recorded at the National Park were evaluated according to guidance and data provided by Invasive Species Specialist Group (ISSG) and Centre for Agriculture and Biosciences International (CABI) developed Invasive Species Compendium (ISC) and also Circular 35/2018/TT-BTNMT. Result showed that 29 species were invaders and especially 11 species of them are detailly evaluated in 10 habitats. 2 species as Mexican sunflower (Tithonia diversifolia) and Lantana (Lantana camara) are evaluated as High risk for both areas while 3 other ones are evaluated as High risk for buffer zone only, including Giant sensitive tree), Leucaena (Leucaena leucocephala) and Giant sensitive plant (Mimosa diplotricha). The other ones have been evaluated as Medium risk (at buffer zone) to Low risk (at core area) are Blackjack (Bidens pilosa), Siam weed (Chromolaena odorata), Bay Biscayne creeping-oxeye (Sphagneticola trilobata), Jamaica cherry (Muntingia calabura), Jamaica vervain (Stachytarpheta jamaicensis) and Coast morning glory (Ipomoea cairica). By this evaluation, Mexican sunflower (Tithonia diversifolia), Blackjack (Bidens pilosa), Jamaica cherry (Muntingia calabura), Jamaica vervain (Stachytarpheta jamaicensis) and Coast morning glory (Ipomoea cairica) are suggested to include to the list of invasive organisms of the nation. Besides that, it is necessary to strengthen control of Mexican sunflower (Tithonia diversifolia) inside the core area of the NP in particular and in Ba Vi district in general, especially at the tourist place where the festival of Mexican sunflower has been yearly organized.
Policy Implications for Social Development Management in the Context of Digital Transformation in Ho Chi Minh City, Binh Duong, and Tay Ninh Province
Authors: Huu Hoang Nguyen , Van Huan Tran 
Published: March 2023

Social development management in the context of digital transformation is a new issue in Vietnam. From a cross-sectional study that includes a survey of 438 civil officials and 450 individuals in Ho Chi Minh City, Binh Duong, and Tay Ninh province, this article analyzes the current state of social development management on six dimensions: Sustainable poverty reduction; health care; education and training; gender equality; social safety, human security and the effectiveness and efficiency of management of the public apparatus in the digital transformation process. The results show that two subject groups gave good and positive evaluation of social development management in these six dimensions. Yet, the two dimensions with the lowest ratings for social development management in the digital age are education and training and health care. The study also recommends that more attention should be given to socially disadvantaged groups to reduce inequality and digital gap in the digital transformation process.
Keywords: Digital inequality, policy, digital transformation, social development management, digital gap.
Leadership and Organizational Commitment of Vietnamese Employees During the COVID-19 Pandemic
Authors: Trung Kien Nguyen , Tsutomu Konosu 
Published: March 2023

The COVID-19 pandemic hit the world as a massive and sudden shock. Organizations are having difficulties to complete their objectives while ensuring employees’ safety whereas employees are suffering from mental and psychological health concerns, in addition to work difficulties, consequently affecting their organizational commitment. In this context, organizations and employees look up to leaders for their responses. The present study tackles leadership and organizational commitment of Vietnamese employees during the COVID-19 pandemic using the quantitative methodology. Participants are 267 Vietnamese employees who are currently working under heavy restrictions. The findings show that transformational leadership is the most prominent leadership style in Vietnam during the pandemic, following by transactional leadership. Transformational leadership has a strong and positive relationship with organizational commitment. Transactional leadership has a moderate and positive relationship with organizational commitment. The relationship appears to be weak and negative in the case of passive/avoidant leadership. The outcomes of leadership, most notably leaders’ effectiveness in dealing with group and individual interests and members’ satisfaction also show a strong and positive correlation with organizational commitment. The present study also delivers recommendation to leaders that the aspect of individual consideration should receive more attention as it helps to ease members’ struggle during the crisis, increase their satisfaction, and consequently improve their organizational commitment.
Keywords: Leadership, transformational leadership, transactional leadership, organizational commitment, COVID-19, pandemic.
A EDUCAÇÃO INFANTIL E A BNCC: O CONTEXTO DAS AVALIAÇÕES EXTERNAS EM LARGA ESCALA
Authors: Da Rocha Louzada Virginia Cecilia 
Published: March 2023

Este ensaio tem por objetivo discutir a presença da primeira etapa a educação básica, a educação infantil (EI), na Base Nacional Comum Curricular (BNCC). Parte do princípio de que o documento provoca empobrecimento do contexto educacional brasileiro, através de um currículo prescritivo, pouca autonomia e reflexão docente, que acaba por restringir a discussão sobre educação a melhorar os índices nas avaliações externas em larga escala. Inicia sua argumentação através do contexto de influência que justifica a entrada da EI no documento para, a seguir, tendo como referência as contribuições das áreas de avaliação e currículo, defender que há relação direta entre a Base e as avaliações estandardizadas, mesmo que, na educação infantil, não seja a proposta avaliar desempenho e/ou desenvolvimento infantil. Argumenta que a relação entre a EI e a Base está diretamente relacionada à questão da alfabetização na pré-escola, já que crianças pré-escolares têm melhor desempenho escolar futuro que as demais. Conclui que a Base pode provocar descaraterização do trabalho pedagógico referendado nas múltiplas linguagens, uma vez que pode contribuir para a antecipação do processo de alfabetização e para processos de escolarização precoce, a partir de uma perspectiva mecanicista, o que contraria os princípios epistemológicos e pedagógicos da educação infantil.
LUTA CONTRA A NATURALIZAÇÃO DAS DESIGUALDADES SOCIAIS: SIGNIFICAÇÕES DE EDUCADORES SOCIAIS ACERCA DA PRÁTICA EDUCATIVA
Authors: Duarte Oliveira Carvalho Soraia , De Sousa Moura Teixeira Cristiane 
Published: March 2023

O objetivo do texto é apresentar a análise das significações de Educadores Sociais acerca de sua prática educativa, um fenômeno histórico ainda em construção. O presente artigo é parte integrante de nosso estudo de mestrado em Educação e, tem sua raiz na necessidade de investigar que mediações da prática educativa dos Educadores Sociais contribuem para a formação humana de crianças e adolescentes em situação de pobreza. Apoiamo-nos nos pressupostos do Materialismo Histórico-Dialético proposto por Marx; Engels (2007), na Psicologia Histórico-Cultural a partir das ideias de Vigotski (1995, 2007 e 2009), bem como na compreensão de educação proposta pela Pedagogia Histórico-Crítica de Saviani (2011, 2013). Tais fundamentos possibilitaram a discussão e compreensão do fenômeno por meio da análise de dados produzidos na entrevista e encontros reflexivos (Szymanski; Almeida; Prandini, 2018) com dois Educadores Sociais. Adotamos como procedimento de análise dos dados a proposta analítica dos Núcleos de Significação elaborada por Aguiar; Soares e Machado (2015) e, Aguiar; Aranha e Soares (2021). Como resultados, apreendemos que a Pedagogia Social-Educação Social se apresenta como uma proposta questionadora de porque “ela é ignorada?”; “quais as portas que estão abertas?” Os Educadores Sociais, significam que o seu trabalho constitui um “processo de confrontar essa linha” imposta pela sociedade capitalista, na busca das condições adequadas para a transformação dessa situação, buscando garantir o acesso aos bens culturais e materiais produzidos pelo conjunto da humanidade, os quais eles têm acesso até o momento.
Pengaruh Pemberian Infusa Albedo Semangka terhadap Perubahan Ukuran Diameter Pulau Langerhans Pankreas Tikus Jantan (Rattus norvegicus) Diabetes Mellitus
Authors: Wilujeng Widi Pangestu , Mahmudati Nurul , Ma’rufah Ladiya Fitri , Fadhillah Ninik , Hati Fatmi Indah , Oktavia Gebby Agnessya Esa , Aprianti Aurira Thrisna Dwi , Rustantina Berlian , Rahayuningtyas Nazil Dwi , Azizaturrohmah  , Nurbani Farah Annisa , Faizah Hanik , Hayati Alfiah 
Published: March 2023

Diabetes Mellitus condition (DM) correlates with the damage that occur in pancreas especially in Langerhans islets, one of the damage indicators is diameter changes of Langerhans islets that getting smaller compare with the normal sizes. The use of natural ingredients to control diabetes mellitus can be done by infusing sweet beauty watermelon albedo which can be found abundant in traditional market. Albedo layer of watermelon contain antioxidant compounds that can help to regenerate Langerhans islets of pancreas. This study purpose was to know the effect of giving watermelon’s infusion albedo to diameter of Langerhans islets in diabetes mellitus rats (Rattus norvegicus), and analyze the potential process occurred based on the result as information source for other research. This study used 25 male rats (Rattus norvegicus) as animal model with 5 groups treatment which were normal group, positive group as control (DM without treatment), A group (DM+1000 mg/kgBB watermelon’s infusions albedo), B group (DM+1500 mg/kgBB watermelon’s infusions albedo), and C group (DM+2000 mg/kgBB watermelon’s infusions albedo). After all the treatments, the rats were anesthetized and dissected and then their pancreas was taken. The pancreas was processed into histological slides by fixing the pancreas in a fixative solution (10% formalin) then dehydrated in a series of graded ethanol and embedded in paraffin wax, cut at a thickness of 4 µm, and finally stained with hematoxylin-eosin dye for microscopic observation, according to the stages Histopathological analysis of the gonads was examined using standard methods. Data was collected by measuring the size of Langerhans islets with microscope Olympus CX33 and connected to the raster image application. Data results from this study indicate that watermelon’s infusion albedo had effect to increase the diameter of Langerhans islets of rat with diabetes mellitus
Penentuan Daerah Terdampak Longsor Di Kecamatan Pinang Belapis, Kabupaten Lebong, Provinsi Bengkulu
Authors: Oktarina Mia , Tanjung Muhammad Rizky , Devatama Nadika 
Published: March 2023

Penentuan daerah rawan longsor selain digunakan untuk mitigasi bencana, juga berguna untuk pertimbangan dalam analisa geoteknik dan pengembangan tata ruang wilayah. Lokasi penelitian berada di Kecamatan Pinang Belapis, Kabupaten Lebong, Provinsi Bengkulu. Secara geografis lokasi penelitian terletak pada 20o 59’ 59.7’’ LS dan 102o 09’ 40.3’’ BT serta 30o 04’ 53.4’’ LS dan 102o 14’ 31.8’’ BT, dan secara tektonik berada di bagian Fore Arc Sumatera. Lokasi penelitian memiliki luasan daerah penelitian 9km x 9km dengan skala 1:50.000. Berdasarkan Peta Geologi, lokasi penelitian memiliki lima formasi batuan, yang didominasi batuan vulkanik berumur Tersier. Lokasi penelitian berada di Segmen Sesar Ketaun dengan arah NW-SE yang merupakan sesar geser dextral dan bagian dari Sumatra Fault Zone. Daerah ini memiliki tiga bentuk lahan, yaitu perbukitan, perbukitan tinggi, hingga pegunungan. Dengan kelas lereng mulai dari landai hingga sangat curam. Hasil analisa Lineament didapatkan arah kelurusan utama pada Timur Laut-Barat Daya atau NE-SW, dengan panjang garis kelurusan antara 249 m- 300 m. Kecamatan ini juga memiliki pola persebaran desa secara paralel atau mengikuti arah jalan utama yang berada di zona sesar aktif. Sehingga berdasarkan hasil pembobotan didapatkan Kecamatan Pinang Belapis memiliki potensi bahaya sekitar 90% luas wilayah.
Implementation of Total Quality Management in the Ministry of Religion-Based Education
Authors: Azizi Muhammad Hakim , Bakri Syamsul , Choiriyah Siti 
Published: March 2023

Total Quality Management (TQM) is a school management concept in carrying out the process of education, which can certainly provide a better chance for the development, demands, and dynamics of society. This study aims to find out as well as describe the factors that support the successful implementation of total quality management at SD IT Al-Anis Kartasura, Sukoharjo. Evidence of the successful implementation of TQM at SD IT AL-Anis is shown by the continued increase in input from SD IT Al-Anis Kartasura, often exceeding the specified quota; Including many outputs achieved in the form of achievements, both by teachers and students, as well as the birth of high-competitive outcomes. This research used a qualitative descriptive method, which results in the finding that the successful implementation of TQM is supported by the leadership style of a school principal, through a process from top to bottom in reverse, good communication between stakeholders of educational institutions, rewards, and punishments that are by needs, as well as the existence of a Measurement of the quality of education that continues to be carried out both internally and externally.
FACTORS ASSOCIATED WITH RATIONALITY OF ANTIMALARIA PRESCRIPTION IN PAPUA PROVINCE
Authors: Lingga Irene Sondang , Said Sarhana Sarhana Rassya Aulyah , Ayomi Dina , Rusnaeni Rusnaeni , Gunawan Elsye , Bakri Nur Fadilah , Sianturi Elfride Irawati 
Published: March 2023

Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted. Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.