bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Accuracy of N20 Somatosensory Potential in Patients With Acute Ischemic Stroke and Endovascular Thrombectomy
Authors: Martinez‐Piñeiro Alicia , Lucente Giuseppe , Hernandez‐Perez María , Cortés Jordi , Arbex Andrea , Pérez de la Ossa Natalia , Ramos‐Fransí Alba , Almendrote Miriam , Millán Mònica , Gomis Meritxell , Dorado Laura , Castaño Carlos , Remollo Sebastián , Cuadras Patricia , Garrido Alicia , Guanyabens Nicolau , Broto Joaquim , López‐Cancio Elena , Coll‐Canti Jaume , Dávalos Antoni ,   PROMISE (Somatosensory Evoked POtEntials MonItoring During Acute Ischemic StrokE) Study Group
Published: June 2023

Background
Somatosensory evoked potentials may add substantial prognostic value in patients with acute ischemic stroke and contribute to the selection of patients who may benefit from revascularization therapies beyond the accepted therapeutic time windows. We aimed to study the prognostic accuracy of the N20 somatosensory evoked potential component of the ischemic hemisphere in patients with anterior large‐vessel occlusion undergoing endovascular thrombectomy (EVT).

Methods
Presence and amplitude of the N20 response were recorded before and after EVT. Its adjusted predictive value for functional independence (modified Rankin scale score, ≤2) at day 7 was analyzed by binary logistic regression adjusting by age, mean arterial blood pressure, National Institute of Health Stroke Scale, Alberta Stroke Program Early CT Score, and serum glucose. N20 predictive power was compared with that of clinical and imaging models by using receiver operating characteristics curve analysis.

Results
A total of 223 consecutive patients were studied (mean age, 70 years; median National Institute of Health Stroke Scale score, 18). Somatosensory evoked potential recordings identified the presence of N20 in 110 (49.3%), absence in 58 (26%), and not assessable in 55 patients due to radiofrequency interferences in the angiography room. Before EVT, N20 predicted functional independence with a sensitivity of 93% (95% CI, 78%–98%) and negative predictive value of 93% (95% CI, 80%–98%). The adjusted odds ratio for functional independence was 9.9 (95% CI, 3.1–44.6). In receiver operating characteristics curve analysis, N20 amplitude showed a higher area under the curve than prehospital or in‐hospital variables, including advanced imaging. Sensitivity increased to 100% (95% CI, 0.85–1) when N20 was present after EVT.

Conclusion
Somatosensory evoked potential monitoring is a noninvasive and bedside technique that could help eligibility of patients with acute ischemic stroke for EVT and predict functional recovery.
Institutional Sanctions and Functionalism: Insights from the Most Recent Practice
Authors: Buscemi Martina 
Published: June 2023

Abstract
The article aims to discuss the most recent practice of institutional sanctions in light of contested fundamentals of the law of International Organizations (ios). The analysis delves, in particular, into sanctions adopted by ios having technical mandates in situations of wider political disputes among members, concerning international peace and security issues, amidst the United Nations (UN) Security Council’s failure to take coercive measures under Chapter vii of the UN Charter. Of special interest is the suspension of membership rights and privileges which some technical ios have deliberated following the conflict in Syria and the undergoing war in Ukraine (para. 2). These instances offer a test bed to challenge the fundamental theoretical paradigm of the law of ios, that is functionalism, and to extract some ambiguities underlying the essence of ios, revealing the continuous oscillation between policy and technocracy, which is endemic to the institutional life of every io and is well reflected in the different attitudes of the members and the Secretariats. The article highlights, in particular, the tension between politics and law that emerges from the adoption of sanctions by ios endowed with highly technical tasks (para. 3), the invocation of the ‘politicisation’ mantra by the targeted member to oppose the application of the privative measures (para. 4), and the ambivalent use of functionalist ‘language’ within the reacting io (para. 5). The article concludes with some final remarks on the ‘strategic’ use of ios (para. 6).
Singin’ in the Night
Authors: Muscianisi Domenico Giuseppe 
Published: June 2023

Abstract
Starting from present-day German Nachtigall ‘nightingale’, which shows an uncommon and unexpected i-linker, this article provides a morphological analysis of the word and its cognates. Through the frame of historical linguistics, and in particular the historical phonology and morphology of Proto-Germanic, it can be shown that Nachtigall and its Germanic cognates witness a relic word-formation that can be traced back to a delocatival compound in Proto-Indo-European. Comparative evidence allows for just such an etymology within poetic phraseology as well.
Heilige Solisten und Klostergemeinschaften
Authors: von Lüpke Beatrice , Blum Daniela 
Published: June 2023

Abstract
The Legendary ‘The Lives of the Saints’ became a medieval bestseller soon after it was composed in the early 15th century. This success was due to its simple, standardised language and its theological programme aimed at promoting a collectively lived spiritality. However, different concepts of holiness or narrative elements such as exorbitantly cruel martyrdoms, the ascetic isolations or mystical excess challenged this homogeneity. The article shows that the redactor was very conscious of these elements and made an effort to even them out. In this way, the Legendary partially counteracts its sources by narrating against a self-sanctification of the human being. Thus, it corresponds to the ideas of the Dominican Observance by developing a kind of literary asceticism.
Financial Incentives for Whistleblowing
Authors: Hogic Nedim 
Published: June 2023

Abstract
This article examines the recent trends in whistleblowing regulation, analysing the issue of financial rewards as one of the key distinctions between the legislative solutions on the matter in the United States as compared to European jurisdictions. Using the lens of corruption theories, the article concludes that the usage of financial rewards increases the overall regulatory capacity of the state to reduce corruption and fraud and reduce the emerging, largely anonymous digital whistleblowing. The financial rewards are also, due to the peculiar nature of both corruption and whistleblowing, an adequate tool to help to quantify the effects of whistleblowing. The article argues that the introduction of financial rewards should not be viewed as dependent on the differences in the legal traditions or culture but on the quality of the institutions and their ability to assess the reports of the whistleblowers. The article offers considerations concerning the conditions for the introduction of financial rewards.
Quasi-Biweekly Oscillation of Surface Sensible Heating over the Central-Eastern Tibetan Plateau and Its Relationship with Spring Rainfall in China
Authors: Hu Wenting , Duan Anmin , Wu Guoxiong , Mao Jiangyu , He Bian 
Published: June 2023

Abstract
This study examines the characteristics and phase evolution of the quasi-biweekly oscillation of surface sensible heating (SH) over the central-eastern Tibetan Plateau (CETP) during spring. The mechanism connecting CETP SH to spring rainfall in China on the quasi-biweekly time scale is further investigated. Results show that the dominant mode of quasi-biweekly CETP SH presents a monopole pattern, in which the peak leads the maximum of the quasi-biweekly rainfall in the middle and lower reaches of the Yangtze River (MLYR) and South China by approximately 5 and 7 days, respectively. As an upper-level Rossby wave train propagates eastward, an anomalous center of convergence moves to the CETP, which leads to a strong downdraft and reduced cloud cover. The resultant elevated shortwave radiation input and drier soil conditions are favorable for the CETP SH quasi-biweekly oscillation to enter a positive phase. When reaching its peak, the CETP SH efficiently heats the lower atmosphere, resulting in a local updraft. Due to the “SH-driven air pump” effect, abundant water vapor is transported from the oceans to China. A lower-layer southerly anomaly on the east side of the TP develops into an anomalous cyclonic circulation via the effect of topographic friction, which leads to the expansion of the positive potential vorticity anomaly and the maximum of the quasi-biweekly rainfall in the MLYR. Further southeastward propagation of the wave train leads to a shift in the rainfall anomaly center to South China. These findings suggest that the CETP monopole SH warming could be a good indicator for predicting intraseasonal variations in spring rainfall over China.
Determining acceptance and perceptions of chemotherapy dose banding in an ambulatory cancer centre
Authors: Ho Britney , Jo Lene Leow , Yap Peter , Lay Mui Poh , Chew Lita 
Published: June 2023

Introduction Despite the advantages of dose banding (DB) and numerous plans to adopt this practice, uptake of DB is still poor. As opinions of healthcare professionals were deemed essential in DB's acceptance, this study surveyed key stakeholders to determine the acceptance, facilitators, and barriers of DB in chemotherapy to improve its implementation. Methods A cross-sectional study at the National Cancer Centre Singapore, involving physicians, nurses, and pharmacy staff, was conducted in February 2022. The Theory of Planned Behaviour was adapted to design a survey questionnaire to obtain the acceptance, facilitators, and barriers of DB. Additional questions on maximum acceptable dose variance and essential criteria for selecting drugs for DB were included. Results A total of 93 participants responded, with a mean 9.75  ±  7.37 years of clinical experience. Less than half have heard of DB while few had prior experience. Drug cost was the top selection criteria for DB, followed by toxicity, therapeutic index, frequency of use and drug wastage. Acceptance rate of DB was 41.9%, with majority agreeing to use DB in various drugs but to determine patient suitability before usage. Being greatly affected by subjective norms, having a positive outlook for DB's impacts, and no effect on toxicity significantly influenced acceptance. Conclusion Prior to implementing DB at the institutional level, educational training addressing concerns over toxicity, and providing technological support can help improve acceptance. Future studies can involve patients’ perspectives and more institutions for greater diversity in opinions.
Technology acceptance of digital devices for home use: Qualitative results of a mixed methods study
Authors: Graeber Johanna , Warmerdam Elke , Aufenberg Svenja , Bull Christopher , Davies Kristen , Dixon Jan , Emmert Kirsten , Judd Claire , Maetzler Corina , Reilmann Ralf , Ng Wan-Fai , Macrae Victoria , Maetzler Walter , Kaduszkiewicz Hanna ,   on behalf of the IDEA-FAST consortium
Published: June 2023

Objective Digital devices have demonstrated benefits to patients with chronic and neurodegenerative diseases. But when patients use medical devices in their homes, the technologies have to fit into their lives. We investigated the technology acceptance of seven digital devices for home use. Methods We conducted 60 semi-structured interviews with participants of a larger device study on their views on the acceptability of seven devices. Transcriptions were analysed using qualitative content analysis. Results Based on the unified theory of acceptance and use of technology, we evaluated effort, facilitating conditions, performance expectancy and social influence of each device. In the effort category, five themes emerged: (a) the hassle to use the device; (b) its usability; (c) comfort; (d) disturbance to daily life; and (e) problems during usage. Facilitating conditions consisted of five themes: (a) expectations regarding a device; (b) quality of the instructions; (c) insecurities with usage; (d) possibilities of optimization; and (e) possibilities to use the device longer. Regarding performance expectancy, we identified three themes: (a) insecurities with the performance of a device; (b) feedback; and (c) motivation for using a device. In the social influence category, three themes emerged: (a) reactions of peers; (b) concerns with the visibility of a device; and (c) concerns regarding data privacy. Conclusions We identify key factors that determine the acceptability of medical devices for home use from the participants’ perspective. These include low effort of use, minor disruptions to their daily lives and good support from the study team.
Emerging applications of extracellular vesicles in tumor therapy
Authors: Luo Hui , Jin Jing , Jin Jiajia , Lou Kecheng , He Hailan , Feng Shangzhi , Zeng Fei , Zou Junrong 
Published: June 2023

AbstractExtracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers.
Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy using macrophage EVs, mesenchymal stem cell EVs, milk EVs, and plant EVs, as well as the advantages of EVs as delivery platforms and their prospective clinical applications and use.
RETRACTED ARTICLE: Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
Authors: Naseer Faiza , Kousar Kousain , Abduh Maisa S. , Anjum Sadia , Ahmad Tahir 
Published: June 2023

AbstractThe in vivo anticancer potential of vincristine (VC) loaded, thiolated chitosan-based nanoformulation (NFs) with an outer hyaluronic acid (VC-loaded in TCs-HA) coating was studied in prostate cancer (PC) xenograft in the immunosuppressed rat model induced by PC3 cell lines. Our previous study has already reported the in vitro efficacy of the said NFs. The ADMET Predictor (TM) Cloud version 10.4.0.5, 64-bit, was used to simulate VC's physicochemical and pharmacokinetic parameters. The percentage of encapsulation efficiency of VC by direct and indirect methods was 81.5 and 90%, respectively. Plasma samples from healthy rats showed improved pharmacokinetic and bioavailability profiles of NFs compared to VC injection via HPLC. The haemolytic analysis of NFs showed two times lesser toxicity to red blood cells. Xenograft rats showed maximum tumour volume up to 235 ± 0.02 mm3 with increased body weight, and it was reduced by 56 ± 0.01 to 107.3 ± 0.03 mm3 during the whole treatment by NFs compared to pure VC. The histopathology of the NFs group showed less malignancy with angiogenesis and significantly less metastasis to the liver and kidney. ELISA showed high expression of apoptotic biomarkers, including Bax, cleaved Caspase 3, and cleaved PARP, while the expression of BCL2, Caspase 3, COX-II, NFκB, and TNF-α was reduced. Immunohistochemical analysis also revealed that post-NF administration, cytoplasmic expressions of TNF-α and COX-II were reduced, as were nuclear expressions of NFκB. Thus, the prepared chemotherapeutic NFs were a comparatively potent oncolytic agent, safe with lesser off-target toxicity, and had an improved pharmacokinetic and bioavailability profile.
Development, successes, and potential pitfalls of multidisciplinary chronic disease management clinics in a family health team: a qualitative study
Authors: Brooks Laura , Elliott Jacobi , Stolee Paul , Boscart Veronique Maria , Gimbel Sarah , Holisek Brittany , Randle Jason , Heckman George Albert 
Published: June 2023

Abstract
Background
The creation of Family Health Teams in Ontario was intended to reconfigure primary care services to better meet the needs of an aging population, an increasing proportion of which is affected by frailty and multimorbidity. However, evaluations of family health teams have yielded mixed results.

Methods
We conducted interviews with 22 health professionals affiliated or working with a well-established family health team in Southwest Ontario to understand how it approached the development of interprofessional chronic disease management programs, including successes and areas for improvement.

Results
Qualitative analysis of the transcripts identified two primary themes: [1] Interprofessional team building and [2] Inadvertent creation of silos. Within the first theme, two subthemes were identified: (a) collegial learning and (b) informal and electronic communication.

Conclusion
Emphasis on collegiality among professionals, rather than on more traditional hierarchical relationships and common workspaces, created opportunities for better informal communication and shared learning and hence better care for patients. However, formal communication and process structures are required to optimize the deployment, engagement, and professional development of clinical resources to better support chronic disease management and to avoid internal care fragmentation for more complex patients with clustered chronic conditions.
Identifying and validating the educational needs to develop a Celiac Self-Care System
Authors: Langarizadeh Mostafa , Rahmati Pakzad , Yousefpour Azari Shahram , Sarpourian Fatemeh , Sayadi Mohammad Javad , Langarizadeh Mohammad Hossein , Fatemi Aghda Seyed Ali 
Published: June 2023

Abstract
Background
Celiac disease is a major public health problem in many countries, including Iran. Considering the disease’s exponential spread throughout the world and its risk factors, identifying the educational priorities and minimum data required to control and treat the disease is of great significance.

Methods
The present study was conducted in two phases in 2022. In the first phase, a questionnaire was developed based on the information obtained from a review of the literature. Later, the questionnaire was administered to 12 pundits in the fields of nutrition (n = 5), internal medicine (n = 4), and gastroenterology (n = 3). As a result, the necessary and important educational content was determined for developing the Celiac Self-Care System.

Results
According to the experts’ viewpoints, the educational needs of patients were classified into nine categories of demographic information, clinical information, long-term complications, comorbidity, tests, medications, dietary recommendations, general recommendations, technical capabilities as well as 105 subcategories.

Conclusions
Due to the increased prevalence of Celiac disease and the lack of an established minimum set of data, determining the required educational information is of great importance at the national level. Such information could be useful in implementing educational health programs to raise the public level of awareness. In the field of education, such contents can be employed in planning new technology based on mobile phones (mobile health), preparing registries, and producing widely used content.
Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort
Authors: Johnston Peter I. , Bogue Patrick , Chirambo Angeziwa Chunga , Mbewe Maurice , Prakash Reenesh , Kandoole-Kabwere Vanessa , Lester Rebecca , Darton Thomas , Baker Stephen , Gordon Melita A. , Meiring James E. 
Published: June 2023

Abstract
Background
Salmonella enterica serovar Typhi (Salmonella Typhi) is the cause of typhoid fever. Salmonella Typhi may be transmitted through shedding in the stool, which can continue after recovery from acute illness. Shedding is detected by culturing stool, which is challenging to co-ordinate at scale. We hypothesised that sero-surveillance would direct us to those shedding Salmonella Typhi in stool following a typhoid outbreak.

Methods
In 2016 a typhoid outbreak affected one in four residents of a Nursing School in Malosa, Malawi. The Department of Health asked for assistance to identify nursing students that might spread the outbreak to other health facilities. We measured IgG antibody titres against Vi capsular polysaccharide (anti-Vi IgG) and IgM / IgG antibodies against H:d flagellin (anti-H:d) three and six months after the outbreak. We selected participants in the highest and lowest deciles for anti-Vi IgG titre (measured at visit one) and obtained stool for Salmonella culture and PCR. All participants reported whether they had experienced fever persisting for three days or more during the outbreak (in keeping with the WHO definitions of ‘suspected typhoid’). We tested for salmonellae in the Nursing School environment.

Results
We obtained 320 paired serum samples from 407 residents. We cultured stool from 25 residents with high anti-Vi IgG titres and 24 residents with low titres. We did not recover Salmonella Typhi from stool; four stool samples yielded non-typhoidal salmonellae; one sample produced a positive PCR amplification for a Salmonella Typhi target. Median anti-Vi and anti-H:d IgG titres fell among participants who reported persistent fever. There was a smaller fall in anti-H:d IgG titres among participants who did not report persistent fever. Non-typhoidal salmonellae were identified in water sampled at source and from a kitchen tap.

Conclusion
High titres of anti-Vi IgG did not identify culture-confirmed shedding of Salmonella Typhi. There was a clear serologic signal of recent typhoid exposure in the cohort, represented by waning IgG antibody titres over time. The presence of non-typhoidal salmonellae in drinking water indicates sub-optimal sanitation. Developing methods to detect and treat shedding remains an important priority to complement typhoid conjugate vaccination in efforts to achieve typhoid elimination.