bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planning, Implementing, and Evaluating Hepatitis C Virus Elimination via Collaborative Community-based Care Cascade: Age-period-cohort Model for Estimating Demand from Antecedent Anti-HCV Survey
Authors: Lin Ting-Yu , Jen Hsiao-Hsuan , Hu Tsung-Hui , Yao Yu-Ching , Chen Tony Hsiu-Hsi , Yen Amy Ming-Fang , Yeh Yen-Po 
Published: July 2023

Abstract
Background Estimating the demand for HCV care cascade plays an important role in planning, monitoring, and assessing the performance of introducing a new community-based hepatitis C virus (HCV) elimination program but such an analytic and systematic approach has been barley addressed.Methods A new collaborative care program for HCV elimination in the Changhua Community of Taiwan has been offered to a total of 895,353 residents since 2018. To grasp the variation of demand for HCV care cascade across demographic and geographic features in the planning stage, we applied the age-period-cohort spatial model to the antecedent anti-HCV survey enrolling 123,617 participants aged 30 years or older between 2005 and 2018. Based on this precise denominator, we then employed a “before-and-after” study design to routinely evaluate whether the WHO criteria of 72% successful treatments could be reached.Results The overall demand for HCV care cascade was 4.28% (HCV infection) of the underlying population but a declining trend was noted. The early cohort had a higher demand whereas the demand of the young cohort decreased with each passing year. The demand also differed by township. The demand, allowing for these variations, for antiviral treatment was 22,362, yielding the WHO target of 12,880 for achieving HCV elimination. With 11,844 successful treatments, the effectiveness of elimination has already reached 92% (11,844/12,880) by the end of 2022.Conclusions The demand for HCV care cascade allows health care decision-makers to timely and properly assess the performance of a novel community-based collaborative care program in achieving HCV elimination.
Identification of a novel hypermethylation marker, ZSCAN18, and construction of a diagnostic model in cervical cancer
Authors: Yang Jinhao , Chen Shuang , Wang Ping , Zhao Jing , Shao Heng , Wang Rong 
Published: July 2023

Abstract
Background
Cervical cancer is a common malignant tumor in women that seriously threatens women’s lives and health. DNA methylation markers have been reported to be related to cervical cancer. Therefore, to find more biomarkers, we adopt a “dry- and wet-lab” strategy that combines bioinformatics, machine learning and experimental methods for novel methylation biomarker identification.
Results
According to the data of cervical cancer samples from TCGA and GEO, 18 differentially methylated CpGs (DMCs) were obtained by integration analysis of the methylome and transcriptome. After assessment through the ROC curve in both the identification cohort (n = 349) and validation cohort (n = 414) from datasets, 5/18 top CpG sites were obtained as potential methylation biomarkers. Subsequently, a series of validation experiments were performed on 3/5 CpG sites which were all located in the promoter of ZSCAN18. First, pyrosequencing results showed that the methylation level of the ZSCAN18 promoter was significantly higher in cervical cancer tissues than in normal tissues (△β value > 0.33, P < 0.05). Then, the methylation PCR (MSP) results showed that the hypermethylation rate in cervical cancer tissues was 80%, which was significantly more than 30% in normal tissues (P < 0.05). Eventually, the quantitative methylation PCR (QMSP) results in cervical thinprep cytologic test (TCT) samples of different lesion stages showed that both the level and positivity of ZSCAN18 methylation increased with the grade of cervical lesions, and the positivity rate was up to 77.8% (21/27) in cancer samples. Further diagnosis models showed that the ridge regression model (RR) had the best performance of the six machine learning models, with AUC areas of 0.9421 and 1.0000 in the validation and mock test cohorts, respectively. Functional analysis demonstrated that overexpression of ZSCAN18 repressed the proliferation of cervical cancer cells (P < 0.05).
Conclusions
In this study, we established a rapid, effective and systemic research strategy to screen novel methylation markers for cervical cancer. The level of ZSCAN18 promoter methylation increases with the severity of cervical lesions and can be used as a DNA methylation biomarker for cervical cancer. The diagnostic model can improve the diagnostic ability.
Water Can Copy and Reproduce the Size of its Clusters and Other Molecules
Authors: Shevchenko Igor V. 
Published: July 2023

Abstract
Water dissolved in an organic solvent does not decompose into individual molecules, but forms clusters, the size of which can vary from a few water molecules to several hundreds. If bulk water is added to acetonitrile containing a small amount of water clusters, it will copy the size of these clusters and reproduce them in large numbers. Small clusters are much more reactive than large clusters because they contain more free hydroxyl groups. Therefore, depending on the size of the initial clusters in the solvent, the added water may turn into a large number of small active clusters, or a small number of large passive clusters. As a result, the rate of hydrolytic reactions with the same water added to acetonitrile can vary up to 500 times. Water can also form clusters upon contact with organic molecules.
Identification and validation of seed dormancy loci and candidate genes, and construction of regulatory networks by WGCNA in maize introgression lines
Authors: Ma Xiaolin , Feng Liqing , Tao Anyan , Zenda Tinashe , He Yuan , Zhang Daxiao , Duan Huijun , Tao yongsheng 
Published: July 2023

Abstract
Seed dormancy (SD) and pre-harvest sprouting (PHS) affect yield, grain and hybrid quality in seed production. Therefore, identification of genetic and regulatory pathways underlying PHS and SD is key to gene function analysis, allelic variation mining and genetic improvement. In this study, 78,360 SNPs by SLAF-seq of 230 maize backcross introgression lines (ILs), PHS under five environments were used to conduct GWAS (genome wide association study) (a threshold of 1/n), and seventeen unreported PHS QTLs were obtained, including eleven QTLs with PVE >10% and three QTLs under multiple environments. Two QTL loci were co-located between the other two genetic mapping methods. Using differential gene expression analyses at two stages of grain development, gene functional analysis of Arabidopsismutants, and gene functional analysis in the QTL region, seventeen PHS QTL-linked candidate genes were identified, and their five molecular regulatory networks constructed. Based on the Arabidopsis T-DNA mutations, three candidate genes were shown to regulate for SD and PHS. Meanwhile, using RNA-seq of grain development, The weighted correlation network analysis (WGCNA) was performed, deducing five regulatory pathways and target genes that regulate PHS and SD. Based on the conjoint analysis of GWAS and WGCNA, four pathways, nine target proteins and target genes were revealed, most of which regulate cell wall metabolism, cell proliferation and seed dehydration tolerance. This has important theoretical and practical significance for elucidating the genetic basis of maize PHS and SD, as well as mining of genetic resources and genetic improvement of traits.
Effect of Agrotechnical Measures on Chemical Composition of Early Potato Tubers
Authors: Sreć Zorana , Vujasinović Vuk , Mišković Anđelko , Mrkonjić Zorica , Bojović Mirjana , Nikolić Olivera , Vasić Vesna 
Published: July 2023

Abstract

Potatoes hold a significant position as one of the most important crops. Their value lies not only in their nutritional composition but also in their function as raw materials for various processing purposes. Furthermore, the cultivation of early potatoes carries considerable agrotechnical importance due to their ability to serve as the initial crop in intensive crop rotation, optimizing the utilization of agricultural soil.
The primary objective of its production is to reach a consistent and high yield of premium quality. Additionally, the aim is to enter the market as early as possible and maximize profitability. To achieve these goals, producers utilize specific agrotechnical measures such as mulching and plant covering to ensure earlier and safer production, thus maximizing profits.
Our research aimed to determine the impact of different agrotechnical measures (biodegradable mulching, agrotextile, low tunnel) on the chemical composition of early potato tubers.
A three-year field experiment was managed in Begeč with two early potato cultivars, Cleopatra and Riviera. The tested agrotechnical measures significantly influenced the quality of early potatoes, hence the increase in the content of dry matter, starch, vitamin C, cellulose, and ash in the tubers and on reduction of sugar and nitrate content.
Competition between stochastic neuropeptide signals calibrates the rate of satiation
Authors: Andermann Mark , Zhang Stephen , Kim Angela , Madara Joseph , Zhu Paula , Christenson Lauren , Lutas Andrew , Kalugin Peter , Jin Yihan , Pal Akash , Tian Lin , Lowell Bradford 
Published: July 2023

Abstract

We investigated how transmission of hunger- and satiety-promoting neuropeptides, NPY and αMSH, is integrated at the level of intracellular signaling to control feeding. Receptors for these peptides use the second messenger cAMP. How cAMP integrates opposing peptide signals to regulate energy balance, and the in vivo spatiotemporal dynamics of endogenous peptidergic signaling, remain largely unknown. We show that AgRP axon stimulation in the paraventricular hypothalamus evokes probabilistic NPY release that triggers stochastic cAMP decrements in downstream MC4R-expressing neurons (PVHMC4R). Meanwhile, POMC axon stimulation triggers stochastic, αMSH-dependent cAMP increments. Release of either peptide impacts a ~100 µm diameter region, and when these peptide signals overlap, they compete to control cAMP. The competition is reflected by hunger-state-dependent differences in the amplitude and persistence of cAMP transients: hunger peptides are more efficacious in the fasted state, satiety peptides in the fed state. Feeding resolves the competition by simultaneously elevating αMSH release and suppressing NPY release, thereby sustaining elevated cAMP in PVHMC4R neurons. In turn, cAMP potentiates feeding-related excitatory inputs and promotes satiation across minutes. Our findings highlight how biochemical integration of opposing, quantal peptide signals during energy intake orchestrates a gradual transition between stable states of hunger and satiety.
Form deviation and surface quality of additively manufactured propellers and their associated acoustic and aerodynamic performance
Authors: Chavez-Tolentino Cesar , Li Xinrong , Siller Hector R , Sadat Hamid 
Published: July 2023

Abstract
This paper explores the effects of surface texture on noise response and propeller-media interaction for additively manufactured (AM) features of unmanned aerial vehicles (UAV) rotary propellers. The microgeometry nature of material extrusion (ME), molding in additively manufactured molds, and vat polymerization (VP) processes was captured with areal texture measurements, and further aerodynamic and acoustic tests allowed to differentiate among these AM technologies. Three layer thickness values of 50 µm, 125 µm and 254 µm were tested on fabricated rotary blades at eight different rotational speeds ranging from 4000 RPM to 7500 RPM by increments of 500 RPM; measuring their thrust, torque, vibration and sound pressure level (SPL). The experimental results showed the overall sound pressure level (OASPL) is mostly constant around the recording microphones. Surface roughness and RPM were the main factors that affect performance. AM propellers exhibited a thrust loss with an associated OASPL decrease; with blades fabricated via VP having the least form deviation and best surface quality, outperforming other specimens compared against the commercial off-the-shelf (COTS) baseline. Expected advantages of using VP over COTS include onsite production and customization.
Efficient Removal of Reactive Textile Dye using Electro-Fenton Process: Response Surface Methodology Approach
Authors: Karabacakoğlu Belgin , Karaduman Serhat 
Published: July 2023

AbstractElectro-Fenton (EF) is a system where electrooxidation and electrocoagulation come together. In the EF method, it is aimed at creating OH radicals in an electrochemical cell by catalyzing H2O2with Fe2+ions. In this study, optimization of process variables for the removal of reactive azo dye (reactive yellow 145) from aqueous solution by the electro-Fenton method was carried out using response surface methodology. The percentage of dye removal and energy consumption were selected as the response functions for the 5 variables determined as voltage, H2O2concentration, pH, electrode spacing, and processing time. As a result of 32 experiments determined by the Design Expert 13 program, the effect of variables on response functions was examined separately and together. 10 V voltage to 99.4%, which is the highest removal; pH 2.5; 1 cm electrode range; 1 mL H2O2addition; and 22.16 Wh/L energy consumption in a 70-min treatment time were reached. The optimum values of the variables proposed by the program to ensure the highest dye removal efficiency (approximately 93%) and the lowest energy consumption (approx. 3.4 Wh/L) are approximately 9.4 V voltage, pH 3.7, 2.5 cm electrode range, 1 mL H2O2addition, and a 40-minute treatment time.
Approximate solutions of optimal control problems for a fractional stochastic integro-differential inclusion with Rosenblatt process
Authors: Yan Zuomao 
Published: July 2023

Abstract
This work is devoted to establish the optimal solutions of optimal control problems for a class of fractional impulsive stochastic integro-differential inclusions with Rosenblatt process and infinite delay in Hilbert spaces. Firstly, using the fractional calculus, the measure of noncom-pactness, properties of fractional resolvent operators and a fixed-point theorem, the existence of mild solutions for these systems is presented. Secondly, the existence of approximate solutions of optimal control problems without the hypotheses of compactness is also obtained. Finally, two examples are given to show applicability of our results.
2020 MR Subject Classification: 34A37; 60H15; 34K50; 26A33; 93E20
On the zeros of polynomial with real coefficients
Authors: Ibrahim Mohammad Ibrahim Mir , Jamina Jamina Banoo 
Published: July 2023

Abstract
Lot of research work has been done regarding the classical theorem known as Eneström-Kakeya theorem concerning the regions containing zeros of a polynomial. This theorem states that if F(z) = ∑n λ=0 fλzλ is a polynomial with degree n with real coefficients satisfying 0 ≤ f0 ≤ f1 ≤ f2 ≤ · · · ≤ fn, then all the zeros of F(z) lie in |z| ≤ 1. In this article, we prove several extensions of this theorem which impose restrictions only on the coefficients f0, f1, · · · , fn−1 and leaves the coefficient fn to vary freely over the whole complex plane.
An Overview of the Basic Characterizations of Nonlinear Optical Single Crystals of Mandelic Acid S-alanine Hemihydrates – For Optoelectronic Applications
Authors: Sivakumar K. , Umarani P. , dhas Sahaya jude Sathiya , Usharani S. 
Published: July 2023

Abstract

Over the years, growing highly efficient crystals in performing multi-level applications has consistently consolidated its position whereby a good number of novel crystals are kept added such that the emerging technology keeps on moving to the next possible level. On this count, R-Mandelic acid S-alanine hemihydrate (RMSA) single crystals with nonlinear optical (NLO) activity were produced at 37°C by the solvent evaporation technique. X-ray diffraction assessment on the single crystal as well as in the powder form was used to estimate the lattice constants. The crystal structure of RMSA is found to be triclinic. According to the transmission spectrum, RMSA's UV cutoff wavelength is 268 nm. Using FTIR spectroscopy, the vibrations of functional groups were clarified. The 13C-NMR spectroscopy was used to determine the molecular structure of RMSA. The Kurtz-Perry SHG test revealed that SHG was existent at a considerable level. When RMSA is compared to pure alanine, the SHG efficiency is discovered to be higher. Utilizing the He-Ne laser and single-beam Z-scan technology, a third-order nonlinear optical investigation was carried out. Positive nonlinearity in RMSA was revealed by a closed-aperture approach, while reverse saturation was revealed by an open-aperture analysis. The obtained results establish the possibility of RMSA as a crystal to be used in optoelectronic and optical device applications to obtain output with high efficiency.
Prognostic impact of primary tumor location in colorectal liver metastases - right-sided colon versus left-sided colon versus rectum: a single-center retrospective study
Authors: Guo Hui-Long , Chen Jing-Yao , Tang You-Zhen , Zeng Qian-Lin , Hu Zhen , Zhang Yi-Fan , Xiang Song , Li Ming-Zhe , He Yu-Long , Wu Wen-Hui 
Published: July 2023

AbstractPurpose Currently, right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (REC) are typically considered as different tumor entities when discussed. The curative effect and different prognoses of patients with colorectal liver metastases (CRLM) whom underwent simultaneous radical surgery are studied based on the site of the primary tumor. Methods This study analyzed 215 patients with CRLM at the First Affiliated Hospital of Sun Yat-sen University and were treated with radical surgery from 2008 to 2021. All data were analyzed by SPSS. Results Ratio of right colon liver metastasis (RCLM) of longitudinal diameter of primary tumor ≥ 5cm was more than left colon liver metastasis (LCLM) and rectal cancer liver metastasis (ReCLM) (61.0% versus 34.3% versus 33.3%, p = 0.001), and similarly for Percentage circumference of intestinal wall involved=1 (74.6% versus 57.8% versus 50.0%, p = 0.021).The three-year overall survival (OS) of RCLM group was significantly less than LCLM group and ReCLM group (37.5% versus 64.7% versus 62.5%, p = 0.016). The univariate and Multivariate analysis showed Percentage circumference of intestinal wall involved, lymph node metastasis and CA199 were the independent risk factors for OS of RCLM, and Percentage circumference of intestinal wall involved and CA199 were the independent risk factors for DFS of CRLM. Conclusion Primary tumors should be considered when analyzing the outcomes of CRLM.
New contribution to the biostratigraphy of Naopurdan limestone unit (Eocene), Bulfat area, Sulaimaniyah, Kurdistan Region, NE Iraq.
Authors: Ghafor Imad , Muhammad Hemn 
Published: July 2023

Abstract

Forty- nine samples were collected for a biostratigraphic study of the Naouprdan limestone unit to determine the age of its strata. The studied section is located within the Zagros High Fold and Thrust Belt. The lithology of the succession here is composed of grey fine-grain of limestone withNummulitesandAlveoloina,the whole section is highly deformed and fractured. Hence, for the first time, this limestone unit describes in detail; it is a 48 m bed of grey fine-grain, Alveolinidae-Nummulitidae limestone. It bears a frequent number of large benthic foraminifera that are concentrated within the limestone bed. It is detected within the Naopurdan succession from the Bulfat area, Sulaimaniyah, Kurdistan Region/northeastern Iraq. The identified-benthic foraminifera are of the groups: Nummulitidae; Alveolinidae; Acervulinidae; Acervulinidae; Rotaliidae; Linderinidae; Linderinidae; Hauerinidae; Textulariidae; Textulariidae. A detailed study of the benthic foraminiferal assemblages of the limestone unit revealed the occurrences of (104) species of benthic foraminifera belonging to (11) genera. The stratigraphic distribution of these species permits the recognition of four biozones. These are from the lower to upper part of the section:Alveolina oblonga-Nummulites djokdjokartaeInterval Zone,Nummulites djokdjokartaeTotal Range Zone,Nummulites fabianiTotal Range Zone andAlveolina leupoldi-Alveolina ellipticaInterval Zone. This study demonstrates that the lithology of this limestone bed is equivalent to the Nummulitic Naopurdan group of the Zagros Low Fold and Thrust Belt since they have similar lithology and fossil contents. This section has not previously been described.
Surgery-induced necrotizing scleritis after vitrectomy with removal of dislocated intraocular lens and secondary iris-claw IOL implantation
Authors: Mártires Pablo González de los , Pérez Gonzalo Guerrero , Bujanda Iñigo Les , Guerra Iñaki Elejalde , Mulero Henar Heras , Silva Esther Compains 
Published: July 2023

Abstract
Purpose To report a surgical-induced necrotizing scleritis, as well as its medical and surgical management.Methods Case-reportResults An 88 year-old patient with a three-day severe single-left-eye ocular pain. One-time surgery involving PPV with removal of dislocated intraocular lens and secondary implantation of iris-claw Artisan® lens was performed six months earlier. Visual acuity of 20/100. Slit-lamp examination revealed a 5x2 mm non-suppurative superior scleral defect. Empirical topical antibiotic treatment with dexamethasone, as well as oral doxycycline was started. Infectious and autoimmune diseases were ruled out. Non-infectious scleritis treatment was conducted with intravenous Methylprednisolone three day pulses, followed by weekly tapered Prednisone and intramuscular Methotrexate. However, one month after the diagnosis, the defect was worsened; hence, a heterologous scleral patch graft was performed and, days after the intervention, Adalimumab was initiated. To date, six months later, remains with proper scleral patch, a diary low-dose Prednisone, and spacing Adalimumab treatment.Conclusion: Surgery-induced necrotizing scleritis is a severe condition that compromise the ocular and visual integrity. Proper diagnosis, as well as early treatment is required to achieve remission, prevent relapses, and avoid structural complications. In refractory cases, anti-TNF-α immunotherapy associated with surgical tectonic graft interventions can achieve promising results.
The efficacy of 308-nm excimer laser monotherapy versus combined with topical bimatoprost 0.03% solution for the treatment of facial vitiligo
Authors: Ghiasi Maryam , Isazade Ahdie , Marhamati Tahereh , Lajevardi Vahideh , Shakoei Safoura 
Published: July 2023

Abstract
Vitiligo is a commonly acquired autoimmune pigmentary disorder. Some patients are resistant to conventional treatments, leading to the search for combination therapies. This study aimed to compare the efficacy of 308-nm excimer laser monotherapy versus combined treatment with topical bimatoprost 0.03% in patients with vitiligo on the face. This study was conducted on patients with facial vitiligo referred to a hospital in Tehran, Iran. The study included 38 patients who were randomly allocated to either the intervention group (18 patients) or the control group (20 patients). Both groups received treatment with a 308-nm excimer laser twice a week for 15 weeks. In addition, the intervention group received treatment with bimatoprost 0.03% solution once daily for 15 weeks. The patients were visited at the end of every 5 weeks and after the 15th week. The efficacy of the treatments using the scale for assessment of improvement, visual analog scale satisfaction (VASS), and visual analog scale improvement (VASI) were evaluated. The study also evaluated the side effects of treatment. The average scores for the measures over time indicated that VASI scores after the 30th treatment session (P = 0.04), VASS scores after the 20th session (P = 0.04) and 30th session (P = 0.03), and SAI scores after the 30th session (P = 0.03) were significantly higher in the intervention group than in the control group. The addition of bimatoprost 0.03% to the treatment regimen may improve the outcomes of patients with facial vitiligo who are resistant to conventional treatments.