bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Novel Imidazopyrazine Derivative against Breast Cancer via Targeted
NPY1R Antagonist
Authors: Niranjan Vidya , R Vibha , Philip Sarah , Uttarkar Akshay , Kusanur Raviraj , Kumar Jitendra 
Published: May 2023

Introduction:
Breast cancer is the most frequent malignancy in women with more than one in ten new cancer
diagnoses each year. Synthetic products are a key source for the identification of new anticancer medicines and
drug leads.

Objectives:
Imidazopyrazine is a highly favored skeleton for the design of new anticancer drugs. In silico designed
derivatives were screened using computer aided drug design techniques and validated using MTT assay.

Methods:
A template-based methodology was used in the current work to create novel Imidazopyrazine derivatives,
targeting the NPY1R protein. Molecular docking, Diffusion docking, MD simulation, MM-GBSA and meta-dynamics
techniques were followed. MTT assay was performed to validate the activity of principal compound.

Results:
A docking score of -6.660 and MMGBSA value of -108.008 (+/-) 9.14 kcal/mol was obtained from the investigations
conducted. In addition, molecular dynamics simulation was carried out for 500 ns, yielding a stable RMSD
and value of 5.6 Å, thus providing insights on the stability of the protein conformation on interaction with the principal
compound. Furthermore, the in vivo validation studies conducted via MTT assay showed an IC50 value of 73.45 (+/-)
0.45 μg /mL.

Conclusion:
The research has produced encouraging findings and can be applied as a model for precise enumerations
in the future. It also encourages the study of novel synthetic compounds with potential anti-cancer properties.
Primary Cutaneous Mucormycosis: A Necrotising Soft Tissue Infection
with Poor Prognosis
Authors: Dogra Poornima , Singla Nidhi , Kaushik Robin , Singh Simrandeep , Gupta Varsha 
Published: May 2023

Background:
Cutaneous mucormycosis is an unusual fungal infection that continues to
occur. It needs aggressive surgical debridement and timely administration of antifungals due to its high
fatality rate. High clinical suspicion on the part of a surgeon is required to prevent the same.

Case Presentation:
We present two cases of cutaneous mucormycosis in which the patients succumbed
to death, highlighting the seriousness of the condition. One patient had a lower leg ulcer and was diabetic,
and the other patient had a gluteal abscess following an intramuscular injection. Tissue samples
grew Rhizopus arrhizus and Apophysomyces sp., respectively. Both patients were treated with amphotericin
B, and extensive debridement was performed.

Discussion:
Cutaneous mucormycosis can be reported in immunocompetent people, and there is a
need for early recognition of the entity as a differential diagnosis of any nonhealing necrotic ulcer.

Conclusion:
Proper training and education of technical and clinical staff should be done at peripheral
primary and secondary care centres so as not to miss out on cases of mucormycosis and for better
prognosis in a cutaneous variety of mucormycosis in surgical patients.
miRNA-363-3p Hinders Proliferation, Migration, Invasion and Autophagy of
Thyroid Cancer Cells by Controlling SYT1 Transcription to affect NF-κB
Authors: Zhang Jizong , Ren Guanghui , Huang Tao , Sang Yiming , Zhong Yan , Yi Yongxiang 
Published: May 2023

Background:
Thyroid cancer (TC) is a frequent endocrine malignant tumor with various pathologic types. miRNA-363-3p plays a pivotal part in the occurrence, development, prognosis, and treatment of cancer.

Objective:
To explore the mechanism of miRNA-363-3p in TC and provide a new idea for targeted therapy of TC.

Methods:
Differential miRNAs and downstream target mRNAs in TC tissues were predicted with bioinformatics analysis. Expression levels of miRNA-363-3p and Synaptotagmin I (SYT1) in TC cells were ascertained by qRT-PCR. Cell migration, invasion, and proliferation were detected by wound healing assay, transwell assay, colony formation assay, CCK-8, and BrdU fluorescence ex-periment, respectively. Flow cytometry was utilized to detect the levels of apoptosis and necrosis. Immunofluorescence assay was used for detecting autophagosome formation in cells, and the ex-pression levels of autophagy-related proteins, as well as NF-κB related proteins, were measured by western blot. Dual-luciferase reporter gene assay was applied for detecting the interaction between miRNA-363-3p and SYT1.

Results:
miRNA-363-3p was prominently down-regulated in TC cells. miRNA-363-3p overexpres-sion suppressed migration, invasion, and proliferation, promoting apoptosis and necrosis of TC cells. As the downstream target of miRNA-363-3p, SYT1 was up-regulated in TC cells. SYT1 overexpression reversed the inhibition of TC cell proliferation, invasion, migration, and autophagy mediated by miRNA-363-3p overexpression. In addition, miRNA-363-3p overexpression inhibited the activation of the NF-κB pathway in cells, while further overexpression of SYT1 weakened the inhibition of miRNA-363-3p overexpression on the NF-κB pathway.

Conclusion:
miRNA-363-3p affected the NF-κB signaling pathway by down-regulating SYT1 ex-pression to inhibit the malignant progression of TC cells, providing theoretical support for the treat-ment of TC.
Growth Hormone Treatment in Children with Perthes Disease and Growth
Hormone Deficiency: A Case Report and Literature Review
Authors: Shi Yuzhen , Ying Yanqin , Luo Xiaoping , Hou Ling 
Published: May 2023

Background:
Perthes disease is an idiopathic femoral head necrosis disease in children. Although it is believed that the prognosis after surgery within 5 years of age is good, there are very few reports in the literature regarding concurrent growth hormone deficiency and the outcome of growth hormone treatment. We retrospectively analyzed and summarized the clinical data of pa-tients with Perthes disease and GHD in a child treated with rhGH for four years.

Case report:
We reported the case of an 11.9-year-old boy diagnosed with “Perthes disease” at 2.7 years. He underwent surgery at the age of 4.8 years and recovered well. At 6.7 years old, he was admitted for “slow growth in height for more than four years.” Physical examination demon-strated severe short stature with a height of 108.8 cm (< 3rd percentile, -2.45 standard deviation (SD)). The major abnormalities observed in the auxiliary examinations included low insulin-like growth factor-1 (IGF-1) (-1.73SD) and low GH peak levels (< 5 μg/L) in the growth hormone stim-ulation test. A diagnosis of complete GHD was confirmed, and low-dose rhGH treatment was ad-ministered. After four years of rhGH treatment, his height reached 152.3 cm (50th-75th percentile, + 0.29 SD). The annual growth rate was approximately 9.1 cm per year, and the curative effect was significant. No adverse reactions were observed during the treatment.

Conclusion:
The benefits of rhGH in children with Perthes disease and GHD may outweigh its risks. However, its safety requires long-term follow-up evaluation.
Bone Marrow as a Therapeutic Target for Type 2 Diabetes Complications
Authors: Cifuentes-Mendiola Saúl Ernesto , Baiza-Gutman Luis Arturo , García-Hernández Ana Lilia 
Published: May 2023

Abstract:
Type 2 diabetes mellitus (T2DM) is a world epidemic with a high prevalence and mor-tality. The origin of macro and microvascular complications associated with T2DM is complex and new mechanisms to explain their development are emerging. The changes induced by T2DM in the microenvironment of bone marrow (BM) alter the expansion and differentiation of stem cells and have been related to the development of micro and macrovascular diseases. Alterations in the differentiation and function of hematopoietic, endothelial, and mesenchymal stem cells in T2DM patients reduced the mobility of BM stem cells to the circulation and some immature, dysfunc-tional, or inflammatory cells pass to the blood (mobilopathy). Consequently, tissue repair is im-paired, and the tissue damage caused by hyperglycemia, oxidative stress, and inflammation is in-creased. These alterations can contribute to diabetic complications, decreasing the quality of life, and increasing mortality. The modulation of the bone marrow microenvironment may be a therapeu-tic target for treating T2DM and its complications. This article analyses the changes induced in BM and their impact on the development of cardiovascular and kidney complications in T2DM. Also, different therapeutic strategies to restore the bone marrow microenvironment and function through the modulation of oxidative stress, inflammation, and adipogenicity are discussed, considering bone marrow as a novel potential therapeutic target to treat vascular complications of diabetes.
Research Progress and Prospect on Profile Roll Forming Methods and
Equipment
Authors: Jing Yigang , Sun Qun , Zhao Ying 
Published: May 2023

Abstract:
In recent years, with the development of aerospace, automotive, rolling stock, shipbuilding,
military weapons and other industries, the demand for bent and rolled parts is increasing, and
the requirements for roll forming accuracy are growing. With the rapid development of coal power,
hydropower, nuclear power, wind power, and petrochemical industries, the design and research on
roll bending machine and the profile roll forming methods have come into focus. The purpose of
this study is to summarize the classification and characteristics of roll bending equipment, analyze
the reasons that affect the accuracy of profile bending, and propose specific solutions. This paper
summarizes the research status and patents on the existing roll bending equipment, introduces its
structural characteristics, differences, and molding effects, and focuses on the difficulties, optimization,
and improvement methods of roll bending molding. In this paper, the mechanical structures
of the existing roll forming equipment have been analyzed and compared, the effects of different
roll forming equipment on the profile bending results have been determined, and the reasons affecting
the bending accuracy have been pointed out. By summarizing the patents and research on profile
roll forming methods and equipment, the current situation and future research prospects of roll
forming equipment are discussed. The roll forming equipment is divided into a roll bending machine,
a CNC roll bending machine, and a flexible roll bending machine. Each design can meet different
profile processing needs. From the design point of view, the optimization under the given
processing profile can achieve relatively high processing accuracy. However, the processing of different
profiles will still produce geometric defects, and there is some space for improvement in the
structure of roll forming equipment, the materials of processing rollers, and the NC interactive system.
Thus, further research on profile roll forming is needed in the future.
Targeted Approach to Enhance the Solubility of Weakly Soluble Drugs by
Nanocrystal Technology
Authors: Rana Sangam , Tomar Deepali , Kaushik Peeyush , Sharma Prerna , Rani Nidhi , Guarve Kumar 
Published: May 2023

Abstract:
About 90% of the newly discovered drugs are poorly soluble in water, to overcome this problem,
nanocrystal technology is used. Nanocrystal technology is a modern technique that is specially
used to increase the solubility of less soluble drugs. Production of a nanocrystal on a large scale can be
done by techniques like homogenization (high-pressure), precipitation, and milling methods. Using this
technique, saturation solubility, the adhesiveness of a drug molecule to the surface cell, and the dissolution
velocity is enhanced. This technology is better than the traditional method because it provides certain
other benefits like increased drug loading capability, fantastic reproducibility of oral retention, further
developed proportionality of portion bioavailability and expanded patient compliance. This audit
makes sense of the various kinds of techniques for the arrangement of nanocrystals, benefits, drawbacks,
a system of solvency improvement, clinical applications, and future imminent. This review article
also provides further guidelines for studies about nanocrystal technology.
Preparation of Folic acid@Arsenic Nanoparticles and Evaluation of their
Antioxidant Properties and Cytotoxic Effects
Authors: Shakibaie Mojtaba , Faraji Maryam , Ranjbar Mehdi , Adeli-Sardou Mahboubeh , Jabari-Morouei Fereshteh , Forootanfar Hamid 
Published: May 2023

Introduction::
In this study, arsenic nanoparticles containing folic acid (FA@As NPs) were
synthesized by microwave irradiating a mixture of As2O3 and sodium borohydride solution in the presence
of folic acid.

Methods::
The physicochemical characteristics of the prepared NPs were studied by UV–visible spectroscopy,
transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray
diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) analyses. Antioxidant activities,
hemocompatibility, and cytotoxic effects of the prepared NPs were then evaluated. The attained results
showed that the hexagonal FA@As NPs have a size range between 12.8 nm and 19.5 nm.

Results::
The DPPH scavenging activity of FA@As NPs was found to be significantly greater than that
of As NPs at concentrations ranging from 40 μg/mL to 2560 μg/mL (p<0.05). The hemolytic test confirmed
that the measured hemolysis percentage (HP) for FA@As NPs and As NPs was 0% at concentrations
between 20 to160 μg/mL, and for FA@As NPs, the measured HP was not significantly higher than
As NPs at concentrations higher than 320 μg/mL (p>0.05).

Discussion::
The necessary concentration for the death of half of the cells (IC50) for MDA-MB-231,
MCF-7, and HUVEC cells treated (24 h) with FA@As NPs was measured to be 19.1±1.3 μg/mL,
15.4±1.1 μg/mL, and 16.8±1.2 μg/mL, respectively. However, further investigations are necessary to
clarify the mechanisms behind the biological activities of FA@As NPs.
An Analytical Method for Determination of Total Iron in Pharmaceuticalgrade
Intravenous Iron Colloidal Complexes by Redox-Potentiometry
Authors: Kamisetty Madhava Krishna , Medisetty Rajesh , Ramesh Bandla , Pappureddy Suresh , Kashanna Jajula , Govinda Varadhi , Kishore Ravada 
Published: May 2023

Background:
Iron carbohydrate complexes are colloidal dispersions made up of polynuclear
Fe(III)-oxyhydroxide cores surrounded by a carbohydrate shell that stabilizes the complex in iron colloidal
formulations. The current study provides an improved method that is precise, accurate, and linear
for quantifying total iron in most Iron Carbohydrate Colloid Drug Products.

Methods:
Redox iodometry with a potentiometric determination is used to evaluate total iron in intravenous
formulations. The visual indicator approach is more prone to fluctuations at endpoint calculations.
Hence, the voltage potential approach is widely accepted as it is more accurate and sensitive. It tracks
the actual change in activity that coincides with the equivalence point that is finally considered an endpoint.
The principle is based on the idea that ferric iron in formulation reduces to ferrous iron in the
presence of the iodide, which oxidizes to iodine. The released iodine is titrated using sodium thiosulfate.

Results:
The proposed method was precise, with %RSD (relative standard deviation) not more than 1.
The method was linear between 80% and 120%, with a linear regression of 0.999. The percent recovery
ranged from 98.20 to 99.98 for the concentration ranges of 80-120. The method's robustness was
checked by various analysts using different reagent grades.

Conclusion:
The proposed potentiometric determination method was precise, accurate, linear, and sensitive.
The method was successfully validated, and the total iron content determined for commercial
batches agrees with the iron claim on the label. Therefore, this method can be adapted widely for total
iron content determination in any Intravenous formulation currently available on the market. The proposed
method is more accessible at the Quality Control facilities on an industrial scale.
Concept of Fasting Therapy in the Traditional Indian Medicine of Ayurveda
Authors: Kumar Syal , Rampp Thomas 
Published: May 2023

Abstract:
Ayurveda is a traditional Indian medical practice, which has at its heart a subcontinent
filled with diverse customs and ethos. Since ancient times, as considered in the Vedas, fasting has
been considered to aid a man’s spiritual life as a means of purification. The body and mind constitute
the substrata of diseases, and the imbalance of Vata, Pitta, Kapha, somatic Doshas, and Rajas
and Tamas (mental doshas) results in various diseases. Derangement of metabolism (Agni) is a major
cause of the imbalance in the abovementioned doshas. In Ayurveda, Agni refers to the complete
process of metabolic activities, both at the levels of the gastrointestinal tract (GIT) and the tissues.
Digestion, metabolism, and assimilation, that is, the entire process of biological conversion and utilisation,
is symbolised by ‘Agni’. The concept of channels and microchannels (srotus) plays a major
role in metabolic processes as particles are transported for various bodily functions through these
channels.

:
The concept of metabolic toxins (Ama) is very relevant in modern times, particularly in the treatment
of many diseases including irritable bowel syndrome, ulcerative colitis, adiposity, hypercholesterolaemia,
obesity, diabetes, rheumatoid arthritis, fibromyalgia, oedema, migraine, chronic fatigue
syndrome, burnout syndrome, various skin diseases and psychiatric and psychosomatic diseases
that occur due to weak digestion and tissue metabolism. The vitiated doshas in the body, particularly
in the stomach, reduce the intensity of or impair digestive activity to cause digestive impairment
and the production of metabolic toxins. They together block the channels in the body
which result in various diseases. Fasting is the absence of food in the viscera or ensuring a controlled
food intake and aids the digestion of metabolic toxins, kindles digestive enzymes, activates
tissue metabolism, and removes the blockage in the channels.
APT Attack Detection of a New Power System based on DPI-transformer
Authors: Zhang Yazhuo , Li Yuancheng 
Published: May 2023

Introduction:
In recent years, the frequent occurrence of network security attacks in the power field has brought huge risks to the production, transmission, and supply of power systems, and Advanced Persistent Threat (APT) is a covert advanced network security attack, which has become one of the network security risks that cannot be ignored in the construction of new power systems.

Objective:
This study aims to resist the increasing risk of APT attacks in the construction of new
power systems, this paper proposes an attack detection model based on Deep Packet Inspection
(DPI) and Transformer.

Methods:
Firstly, we extracted 606 traffic characteristics from the original traffic data through the
extended CIC Flowmeter and used them all to train the Transformer network. Then, we used the
DPI-Transformer model and traffic labels to perform feature analysis on the traffic data and finally
obtained the APT-Score. If the APT-Score is greater than the threshold, the alarm module is triggered.

Results:
By analyzing the headers and payloads of the network traffic in the APT-2020 dataset, the
experimental results show that the detection accuracy of APT attacks by the DPI-Transformer detection
model is significantly higher than that of the current mainstream APT attack detection algorithms.

Conclusion:
Combined with the characteristics of the new power system and APT attacks, this paper
proposes an attack detection model DPI-Transformer, which proves that the model has greatly
improved the detection accuracy.
Protection Challenges on Integration of Distributed Sources to Power system network: A Review
Authors: Shah Hinal , Chakravorty Jaydeep 
Published: May 2023

— Electricity generation has to be increased to meet various type of future load demand like LED lightning, Electrical
Vehicles, mobiles, communication network, non linear load etc. Automation is essential requirement now a days in each sector.
To provide automation at residential, commercial and industrial sectors electrical energy is required. To meet energy
requirement of various sector utility grid is integrated with DG Sources, which mainly include renewable energy sources like
solar, wind and other environment friendly sources either in large scale or small scale depends on the location and availability.
This type of technology leads power system to era of smart grid. Smart grid technology provides features like digitization, two
way communication, distributed generation, adaptive islanding, self monitoring and self mitigating, fully controllable compare to
conventional Grid. Though smart grid technology is advantageous but due to integration of distributed generation at
transmission and distribution system will increase protection challenges in the power network. This paper gives an insight of
different protection issues which occur at transmission, distribution and Micro grid network. The paper also focuses on the
techniques and solution of the various protection challenges.
Post Scriptum de En mi recuerdo veo una sombra
Authors: VERDUGO SALINAS CARLA 
Published: May 2023

RESUMEN: Este ensayo añade algo posterior al texto -audiovisual y escrito- ya concluido, emite la impresión de la autora al espectar su propia obra, y ya más decantado el proceso como observadora de ese mismo proceso lo enuncia y logra entender su flujo. Así en una revisión de lo que constituyera la tesis-obra que le condujo al grado de Magister en Cine y Artes Audiovisuales de la UV, se pone en tensión el ensayo audiovisual, sus conceptos y lo sitúa de frente al tiempo próximo, volviéndole a la vigencia y extendiendo la duración de la obra a través del ejercicio autocrítico.
Palabras clave: Ensayo Audiovisual – Catástrofe – Desaparición forzada – Montaje – Historicidad.
Culture of Safety Quality Improvement Project: Longitudinal AHRQ Survey Results From a Family Medicine Residency Program
Authors: Jefferson Erin , Braly Tyler , Henriksen Brian , Harris Kim 
Published: May 2023

Objectives: This project analyzed the culture of safety quality improvement at the Family Medicine Center (FMC). The Agency for Healthcare Research and Quality (AHRQ) Culture of Safety Survey was used as a benchmark for internal and external comparison.
Methods: The AHRQ Culture of Safety Survey was administered to health care staff in 2015, 2017, and 2019, respectively, at the Family Medicine Center. Baseline perceptions of safety and quality were established using the data from the AHRQ Culture of Safety Survey in 2015. We performed multiple large-scope quality improvement projects that focused on identified deficiencies. The changes in perception were monitored over time every 2 years. We analyzed the results using the Kruskal-Wallace test (P=.05).
Results: The AHRQ Culture of Safety Survey showed statistically significant improvement in patient centeredness, effectiveness, timeliness, efficiency, equitableness, and overall patient safety from 2015 to 2019. Some inconsistencies were seen between different sections of responses, likely due to wording interpretations by the participants.
Conclusion: Overall, the AHRQ Culture of Safety Survey is an effective way to help monitor employee perception of multiple domains that lead to a safe and effective clinical environment as compared to other practices across the country. Clinic-wide implementation of quality and patient care strategies resulted in significant improvements in nearly every category of the survey.