bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with mortality in patients hospitalized for COVID-19 admitted to a tertiary hospital in Lambayeque, Peru, during the first wave of the pandemic
Authors: Aguirre-Milachay Edwin , León-Figueroa Darwin A. , Chumán-Sánchez Marisella , Romani Luccio , Runzer-Colmenares Fernando M. 
Published: May 2023

Introduction
COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread worldwide, becoming a long-term pandemic.

Objectives
To analyze the factors associated with mortality in patients hospitalized for COVID-19 in a tertiary hospital in the Lambayeque region of Peru.

Methods
A retrospective cohort study of patients with a diagnosis of COVID-19, hospitalized in a hospital in northern Peru, was conducted from March to September 2020.

Results
Of the 297 patients studied, 69% were women, the mean age was 63.99 years (SD = ±15.33 years). Hypertension was the most frequent comorbidity (36.67%), followed by diabetes mellitus (24.67%) and obesity (8.33%). The probability of survival at 3 days of ICU stay was 65.3%, at 7 days 24.2%, and 0% on day 14. Risk factors associated with mortality in patients hospitalized for COVID-19 are age, male sex, tachypnea, low systolic blood pressure, low peripheral oxygen saturation, impaired renal function, elevated IL-6 and elevated D-dimer.

Conclusions
Mortality in hospitalized patients with COVID-19 was 51.18 per 100 persons, Mortality was found to be associated with hypertension, type of infiltrating, and sepsis.
Prolonged cardiovascular pharmacological support and fluid management after cardiac surgery
Authors: Kontar Loay , Beaubien-Souligny William , Couture Etienne J. , Jacquet-Lagrèze Matthias , Lamarche Yoan , Levesque Sylvie , Babin Denis , Denault André Y. 
Published: May 2023

Objective
To identify potentially modifiable risk factors related to prolonged cardiovascular pharmacological support after weaning from cardiopulmonary bypass (CPB).

Methods
This is a secondary analysis of two prospective cohort study in a specialized cardiac surgery institution in adult patients undergoing cardiac surgery with the use of CPB between August 2016 and July 2017. Prolonged cardiovascular pharmacological support was defined by the need for at least one vasopressor or one inotropic agent 24 hours after separation from CPB. Risk factors were identified among baseline characteristics and peri-operative events through multivariable logistic regression.

Results
A total of 247 patients were included and 98 (39.7%) developed prolonged pharmacological support. In multivariable analysis, left ventricular ejection fraction ≤ 30% (OR 9.52, 95% confidence interval (CI) 1.14; 79.25), elevated systolic pulmonary artery pressure (sPAP) > 30 and ≤ 55 mmHg (moderate) (OR 2.52, CI 1.15; 5.52) and sPAP > 55 mmHg (severe) (OR 8.12, CI 2.54; 26.03), as well as cumulative fluid balance in the first 24 hours after surgery (OR 1.76, CI 1.32; 2.33) were independently associated with the development of prolonged pharmacological support.

Conclusions
Prolonged cardiovascular pharmacological support is frequent after cardiac surgery on CPB. Severe LV systolic dysfunction, preoperative pulmonary hypertension and postoperative fluid overload are risk factors. Further studies are required to explore if those risk factors could be modified or not.
Estimating the early-life exposure to two perfluorinated compounds (PFOS and PFOA) using PBPK modelling and biomarker measurements
Authors: Ratier Aude , Casas Maribel , Manzano-Salgado Cyntia , Zeman Florence A. , Vrijheid Martine , Brochot Céline 
Published: May 2023

Children exposure to per- and polyfluoroalkyl acids substances (PFAS) is a major concern in health risk assessment as early-life exposures are suspected to induce adverse effects such as cardiometabolic, neurodevelopmental, or impact on immune response. Our work aims to estimate children exposure to PFOA and PFOS using a Physiologically-Based Pharmacokinetic (PBPK) modelling approach.
A lifetime model for PFAS was updated to simulate the internal PFAS exposures during the
in utero life and childhood, and to include individual characteristics and exposure scenarios. Our approach was applied on the HELIX cohort, involving 1,239 mother-child pairs with measured PFOA and PFOS plasma concentrations at two sampling times: during pregnancy and in childhood (6 to 10 y.o).
Our model predicted an increase of the plasma concentrations during fetal development and childhood until 2 y.o when the maximum concentrations were reached. Higher PFOA plasma concentrations than PFOS ones were predicted until 2 y.o, and then PFOS levels gradually became higher than PFOA ones. From 2 to 8 y.o, mean concentrations decrease from 3.09 to 1.88 µg/L (PFOA) and from 4.77 to 3.56 µg/L (PFOS). The concentration-time profiles vary with the age and were mostly influenced by
in utero exposure (0-4 months), breastfeeding (5 months – 2 (PFOA) or 5 (PFOS) y.o), and food intake (after 3 (PFOA) or 6 (PFOS) y.o). Similar measured biomarker levels can correspond to large differences in the simulated internal exposures, highlighting the importance to investigate the child exposure over the early life to improve exposure classification of the child. The simulated internal concentrations in several infants and toddlers exceeded the HBM-I value threshold compared to the ones in older children, especially for PFOA.
Our approach based on PBPK modelling and HBM data demonstrates the possibility to simulate individualized internal exposures, that could be accounted to refine risk assessment in early life.
Intervensi Kelembagaan dalam Pengelolaan Publikasi Ilmiah sebagai Upaya Pengembangan Dalam Bidang Ilmu Kesejahteraan Sosial: Studi Kasus pada WELFARE : Jurnal Ilmu Kesejahteraan Sosial UIN Sunan Kalijaga Yogyakarta
Authors: Umam Khotibul 
Published: May 2023

Kajian ini mengidentifikasi terkait upaya pengelolaan jurnal dalam rangka meningkatkan kualitas publikasi ilmiah. dengan adanya Publikasi ilmiah saat ini sebagai tolak ukur tercapainya tridarma perguruan tinggi. Penelitian ini menjadi penting untuk dikaji dalam rangka mengetahui tentang bagaimana intervensi kelembagaan atau komunitas dilakukan dalam rangka meningkatkan kualitas jurnal. Penelitian dengan menggunakan metode kualitatatif, dengan metode pengumpulan data menggunakan wawancara dan dokumentasi. Metode analisis data yang digunakan adalah metode Miles dan Hubermen membagi menjadi tiga tahapan yaitu display data, reduksi data, dan penarikan kesimpulan. Hasil dari penelitian ini yakni bahwa upaya intervensi kelembangga yang dilakukan dalam praktek pekerjaan sosial bisa memberikan gambaran dalam proses pengelolaan jurnal. upaya peningkatan kualitas sumberdaya manusia baik secara operasional dalam manajemen OJS ataupun kualitas naskah dalam kerangka keilmuan pekerjaan sosial. Hal ini dilakukan melalui berbagai skema yakni pelatihan-pelatihan skala local dan nasional para pengelola, motivasi dan pendampingan proses akreditasi kepada para pengelola, pemberian reward. Sedangkan untuk menjaga ketersediaan naskah dan kualitas diantaranya melalui pelatihan dan pendampingan intensif, kegiatan-kegiatan coference internasioanal yang diajakan oleh fakultas dan prodi.
Kata Kunci : Intervensi kelembagaan, peningkatan kualitas, akreditasi jurnal.

This study identifies journal management efforts in order to improve the quality of scientific publications. With the existence of current scientific publications as a benchmark, the tridarma of higher education is achieved. This research is important to study in order to find out about how institutional or community interventions are carried out in order to improve the quality of journals. Research using qualitative methods, with data collection methods using interviews and documentation. The data analysis method used is the Miles and Hubermen method which divides into three stages, namely displaying data, reducing data, and drawing conclusions. The results of this study are that developmental intervention efforts carried out in social work practice can provide an overview of the journal management process. efforts to improve the quality of human resources both operationally in OJS management or the quality of manuscripts within the scientific framework of social work. This is done through various schemes, namely local and national scale training for managers, motivation and accreditation process assistance to managers, awarding rewards. Meanwhile, to maintain the availability of manuscripts and quality, including through intensive training and assistance, international conference activities held by faculties and study programs.
Keywords: Institutional intervention, quality improvement, journal accreditation
Two Jewish Physicians in Early Modern Germany: Koppel (Jacob) Mehler (AKA Copilius Pictor) and his son Juda Coppillia Pictor
Authors: Reichman Edward 
Published: May 2023

Abstract
The Mehler family was a distinguished German family from Bingen in the 17th and 18th centuries comprised of numerous rabbis and communal leaders. In this essay we draw attention to the physicians of the Mehler clan, a father and son in the late 17th and early 18th centuries. Though graduating just forty years apart, they represent the transition of the medical training of students of Ashkenaz (Poland, Germany, and France) from Italy to Germany. Prior to the mid seventeenth century, a young Jewish student longing to attend medical school had essentially one option, the University of Padua. By the early eighteenth-century German universities began to welcome Jewish students. Our father and son physicians straddle this period and reflect the transition of Jewish medical training from Italy to Germany. We have identified some remarkable archival material allowing us to provide also an illustrated history of their medical careers.
Jüdische Spenden und Stiftungen im fraktalen Raum des Heiligen Römischen Reichs
Authors: Schmölz-Häberlein Michaela 
Published: May 2023

Abstract
The essay deals with the donation activities of Jewish people in the Franconian area during the 18th century. Helping those in need was an integral part of religious practice. Donations to co-religionists as well as to Christian institutions and individuals can be proven regularly. The five charitable foundations, which were set up by wealthy members of the Bamberg rural Jewish community, also served the purpose of maintaining the memory of the founder and his family in the long term. With the proceeds from the foundation capital, scholarships were financed and needy relatives supported. They represented important references for the family members, who often lived scattered. Thus had an effect of forming a Common identity. The case of Meyer Levi, who at the same time established religious foundations in the Franconian rural community of Zeckendorf and the suburban community of Pfersee beyond the gates of the imperial city of Augsburg, documents that the supra-regional and cross-territorial interdependencies of Jewish society can be seen within the Zedaka.
One fits all: a highly sensitive combined ddPCR/pyrosequencing system for the quantification of microchimerism after hematopoietic and solid organ transplantation
Authors: Häuser Friederike , Mittler Jens , Hantal Misra Simge , Greulich Lilli , Hermanns Martina , Shrestha Annette , Kriege Oliver , Falter Tanja , Immel Uta D. , Herold Stephanie , Schuch Brigitte , Lackner Karl J. , Rossmann Heidi , Radsak Markus 
Published: May 2023

Abstract

Objectives
A combined digital droplet PCR (ddPCR)/pyrosequencing assay system was developed that demonstrated advantages applicable to multiple qualitative and quantitative molecular genetic diagnostic applications. Data for characterizing this combined approach for hematologic stem cell transplantation (HSCT) and allele quantification from graft-derived cell-free (cf) DNA in solid organ transplantation (SOT) is presented.

Methods
ddPCR and pyrosequencing assays targeting 32 SNPs/markers were established. ddPCR results from 72 gDNAs of 55 patients after allogeneic HSCT and 107 plasma-cfDNAs of 25 liver transplant recipients were compared with established methods/markers, i.e. short-tandem-repeat PCR and ALT, respectively.

Results
The ddPCR results were in good agreement with the established marker. The limit of detection was 0.02 % minor allele fraction. The relationship between ddPCR and STR-PCR was linear with R2=0.98 allowing to transfer previously established clinical STR-PCR cut-offs to ddPCR; 50-fold higher sensitivity and a variation coefficient of <2 % enable the use of low DNA concentrations (e.g. pre-sorted cells). ddPCR detected liver allograft injury at least as sensitive as ALT suggesting that ddPCR is a reliable method to monitor the transplant integrity, especially when other biomarkers are lacking (e.g. kidney).

Conclusions
Combining pyrosequencing for genotyping and ddPCR for minor allele quantification enhances sensitivity and precision for the patient after HSCT and SOT. The assay is designed for maximum flexibility. It is expected to be suitable for other applications (sample tracking, prenatal diagnostics, etc.).
Comparison and significance of grain size parameters of the Menyuan loess calculated using different methods
Authors: Shi Yunkun , E Chongyi , Zhang Zhaokang , Peng Qiang , Zhang Jing , Yan Wenting , Xu Chunxia 
Published: May 2023

Abstract
Grain size is a fundamental physical property of sediments, and its parameters are crucial indicators of the provenance, transport processes, and depositional environments. However, owing to the availability of graphic and moment method choices for the determination of grain size parameters, the associated data are characterized by inconsistencies, and these issues restrict the utilization of such data. Compared to other regions, comparative analyses of grain size parameters determined using the graphic and moment methods for aeolian sediments in the Tibetan Plateau are scant. To obtain more accurate information and optimize and integrate historical data, in the present study, sediments in the Yahecun section of the Menyuan Basin in the northeastern Tibetan Plateau were investigated. Data for the Menyuan loess show that the mean grain size, sorting, skewness, and kurtosis data obtained from the two methods can be converted using linear equations. However, differences in the descriptions following the establishment of relationships should be considered. Owing to its sedimentary characteristics, the moment method is more suitable for determining grain size parameters for the Menyuan loess. The results from the moment method indicate that the Menyuan loess originated from multiple sources involving varying dynamics, and the sediments recorded changes from a cold, dry to a warm climate.
What End of Thought? On the True and the False Problem of Philosophy
Authors: Leegsma Mark 
Published: May 2023

Abstract
The end of metaphysics problematizes philosophy, for it implies the end of thought “itself.” Though this raises the question how to think after the end of metaphysics, the question can only be asked on the condition that the “problem of philosophy” is posed, presupposing an answer to the question what the end of thought is. This article critically compares two ways of posing that problem. It argues that one, here called active nihilism, poses the problem falsely: it implies an answer to the question what the end of thought is, even as it makes that question impossible to answer, rendering the very problem unsolvable. The true problem of philosophy, the article argues, is what is here called the entanglement of thought and experience. In order to demonstrate what active nihilism and entanglement actually come down to, the article then presents two cases. One involves a detailed analysis of Meillassoux’s refutation of correlationism, showing how the problem of philosophy is rendered unsolvable in actual fact. The other case concerns what is called catastrophal thought. An effective demonstration of the end of thought, this first answers the question what the end of thought really is.
Effect of NB-UVB therapy on IL-6 and neopterin levels in patients with psoriasis
Authors: Sahin Emine Buket , Sanajou Sonia , Girgin Gözde , Akan Tülin , Baydar Terken 
Published: May 2023

Abstract

Background
Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of the immune system is an important factor in this pathology. Inflammation markers, pro-inflammatory cytokines, and immune cells are reported to be changed in psoriasis.

Study design
In the current cohort study, the possible changes in interleukin-6 (IL-6), neopterin levels, and kynurenine (Kyn) pathway in 42 psoriasis patients compared to 30 controls, and their change with narrow-band (NB) UVB treatment were investigated.

Methodology
IL-6 and serum neopterin levels were analyzed with ELISA kits. HPLC analyses were performed to detect urinary neopterin, serum Kyn, and tryptophan (Trp) levels.

Results
IL-6 levels were lower, while Kyn levels and the Kyn-to-Trp ratio were higher in psoriasis patients compared to control subjects (p < 0.01, all).

Conclusion
Narrow-band ultraviolet B (NB-UVB) treatment decreased Psoriasis Area and Severity Index (PASI) scores and increased urinary neopterin levels of the patients (both, p < 0.01). Serum neopterin was correlated with Kyn and Kyn/Trp levels before and after NB-UVB treatment (p < 0.05, all). These findings point out that the measured parameters might be considered to support the PASI score in both diagnosis and prognosis of psoriasis rather than evaluating the severity of the disease.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA MATERI SANGGUL UKEL TEKUK DAN SANGGUL UKEL KONDE
Authors: Aprilliani Clarita 
Published: May 2023

This study aimed to know how to develop an android-based learning media, examine the learning media's validity, and determine studentsâ€™ views toward using the learning media. The learning media was focused on the learning materials of Ukel Tekuk and Ukel Konde Indonesian traditional hair bun (sanggul) for beauty class students in SMK Negeri 3 Magelang. This learning media used PPE (Planning, Production, and Evaluation) as the development model. This research and development study result showed that the online software MIT app Inventor was used to develop the android-based learning media. This learning media was also valid since the total validity percentage of the multimedia experts, and the experts of learning materials was 86.6% with very distinct criteria. By using a questionnaire of media validation to find out the studentsâ€™ views, it showed that the percentage of this learning media was 92% according to studentsâ€™ perspectives. This value is classified as high criteria, so it cam be conclude that the perspectives of students on learning media for Belajar Sanggul are this learning media is easy to use and material presented is easy to understand.
Kelayakan Aksesoris Dari Limbah Kulit Buah Mahoni
Authors: Lestari Mega Ayu , Ihsani Ade Novi Nurul 
Published: May 2023

Abstrak. Kelayakan merupakan kepantasan suatu objek untuk dijadikan sesuatu yang memiliki daya jual. Limbah kulit buah mahoni dapat dibuat menjadi aksesoris karena kharakteristiknya yang kuat dan tidak mudah terurai, kulit buah mahoni juga memiliki motif yang khas sehingga cocok digunakan sebagai bahan pembuatan aksesoris. Tujuan penelitian ini yaitu untuk mengetahui bagaimana proses pembuatan aksesoris, validitas serta kelayakan aksesoris dari limbah kulit buah mahoni. Metode penelitian adalah metode eksperimen, objek penelitian yaitu aksesoris limbah kulit buah mahoni. Teknik pengambilan data menggunakan penilaian angket atau kuisioner. Teknik analisis menggunakan diskriptif presentase. Hasil kelayakan berdasar uji indrawi aksesoris tema Naturalis N1 mendapat presentase 90.28 %, N2 81,94 %, N3 94.44 %, G1 87,50 %, G2 81,99 % dan G3 90,28 % berdasar uji kesukaan yang diujikan kepaada 30 panelis agak terlatih N1 mendapat presentase 89,67 %, N2 88,50 %, dan N3 89 % serta GK1mendapat persentase 89 % , G2 89 % dan G3 90 %. Simpulan penelitian, keenam aksesoris limbah kulit buah mahoni dinyatakan sangat valid oleh validator, serta dinyatakan sangat layak oleh ahli berdasarkan uji indrawi dan dinyatakan sangat suka untuk aksesoris limbah kulit buah mahoni berdasarkan uji kesukaan.
Makna Dan Filosofi Tata Rias Pengantin Khas Temanggung Paes Arga Mliwis Wana
Authors: Listiana Luluk Mei , Krisnawati Maria 
Published: May 2023

Abstrak. Temanggung memiliki keanekaragaman budaya yang berbeda dari lainnya begitupula dengan pernikahan yang berkembang. Penelitian ini membahas bentuk tata rias dan busana serta makna dan filosofi pengantin Temanggung Paes Arga Mliwis Wana. Tujuannya untuk mengetahui bentuk tata rias dan busana serta makna dan filosofi pengantin Temanggung. Penelitian ini menggunakan metode penelitian Kualitatif yang dilakukan di Kabupaten Temanggung Jawa Tengah dengan narasumber perias dan budayawan. Pengumpulan data dilakukan dengan metode observasi, wawancara, dan dokumentasi. Instrumen penelitian yang digunakan berupa pedoman wawancara. Teknik analisis data menggunakan reduksi data, data yang diperoleh kemudian diolah menjadi deskriptif naratif diakhiri dengan penarikan kesimpulan.Adapun Hasil penelitian yaitu pengantin menggunakan bedak sesuai warna kulit, eyeshadow menyesuaikan warna baju, alis menyesuaikan bentuk wajah, blush on merah muda, lipstick merah, paes disebut paes arga mliwis wana. Busana pengantin putri menggunakan kebaya jaggan balak-balakan dan busana pengantin pria menggunakan beskap atilo sendang. Makna filosofi tata rias pengantin yaitu memunculkan aura kecantian pada pengantin. Saran masyarakat Temanggung harus ikut melestariakn, sosialisasi perlu dilakukan melalui kegiatan seminar.
Abstract. Temanggung has a cultural diversity that is different from others as well as a thriving marriage. This study discusses the form of make-up and clothing as well as the meaning and philosophy of the Temanggung Paes Arga Mliwis Wana bride. The aim is to find out the form of make-up and clothing as well as the meaning and philosophy of the Temanggung bride. This study uses a qualitative research method conducted in Temanggung Regency, Central Java, with make-up speakers and cultural observers. Data was collected using the methods of observation, interviews, and documentation. The research instrument used was an interview guide. The data analysis technique uses data reduction, the data obtained is then processed into descriptive narrative ending with drawing conclusions. called paes arga mliwis wana. The bride's attire uses a kebaya jaggan balak and the groom's attire uses a beskap atilo spring. The meaning of the philosophy of bridal makeup is to bring out the aura of beauty in the bride and groom. The advice of the Temanggung community is to participate in preserving it, socialization needs to be carried out through seminars.