bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐Related Differences in the Prognostic Role of Acetylcholine Provocation Testing
Authors: Rinaldi Riccardo , Russo Michele , Occhipinti Giovanni , Laudani Claudio , Torre Ilaria , Colucci Michele , Gurgoglione Filippo Luca , Animati Francesco Maria , Lenkowicz Jacopo , Tudor Andrada Mihaela , Liuzzo Giovanna , Sanna Tommaso , Leone Antonio Maria , Niccoli Giampaolo , Lanza Gaetano A. , Trani Carlo , Burzotta Francesco , Crea Filippo , Montone Rocco A. 
Published: February 2025

Background
Intracoronary provocation testing with acetylcholine (ACh) is helpful to diagnose and risk‐stratify patients with ischemia with nonobstructed coronary arteries (NOCA) and myocardial infarction with NOCA. This study explored potential sex‐related disparities on the prognostic significance of ACh provocative testing.

Methods
Consecutive patients with ischemia with NOCA and those with myocardial infarction with NOCA who underwent ACh provocation testing were enrolled. The primary end point was the incidence of major adverse cardiovascular and cerebrovascular events at follow‐up. Co‐primary end points were angina recurrence and quality of life assessed by 12‐month Seattle Angina Questionnaire (SAQ) summary score.

Results

A total of 519 patients (mean age, 61.4±12.1 years; 275 [53.0%] women and 244 [47%] men) were enrolled: 346 (66.7%) with ischemia with NOCA and 173 (33.3%) with myocardial infarction with NOCA. A positive ACh test was observed in 274 (52.8%) patients, with a lower prevalence of epicardial spasm (82 [56.2%] versus 106 [82.8%]) and a higher prevalence of microvascular spasm (64 [43.8%] versus 22 [17.2%]) in women compared with men (
P
>0.001). After a median 22‐month follow‐up, major adverse cardiovascular and cerebrovascular events occurred in 53 (10.2%) patients, without significant sex differences (
P
>0.05). Men with a positive ACh test had a significantly higher rate of major adverse cardiovascular and cerebrovascular events (22 [17.2%] versus 5 [4.3%],
P
=0.002) compared with those with a negative test; no difference was observed in women (
P
>0.05) (
P
for interaction=0.003). Women with a positive test experienced a higher rate of angina recurrence (61 [41.8%] versus 32 [24.8%],
P
=0.005) and a lower SAQ summary score (82 [interquartile range, 72–90] versus 86 [interquartile range, 78–100],
P
<0.001) compared with those with a negative result; no difference was observed in men (
P
>0.05).

Conclusions
This study revealed the importance of recognizing sex‐specific differences in the prognostic value of ACh testing for proper management of coronary vasomotor disorders.
Excessive Hypercholesterolemia in Pregnancy Impairs Later‐Life Maternal Vascular Function in Rats
Authors: de Oliveira Amanda A. , Elder Emma , Graton Murilo E. , Spaans Floor , Wooldridge Amy L. , Quon Anita , Kirschenman Raven , Cooke Christy‐Lynn M. , Davidge Sandra T. 
Published: February 2025

Background
Preeclampsia is a risk factor for the development of later‐life cardiovascular disease. However, the underlying mechanisms are poorly understood. Excessive hypercholesteremia in pregnancy induces a preeclampsia‐like phenotype, but whether this also impacts maternal vascular function later in life has not been fully characterized.

Methods and Results
Sprague Dawley rats received a control diet (CD) or a high‐cholesterol (HCD) diet from gestational day 6 to 20, after which maternal vascular function was assessed 3 months postpartum. Exposure to an HCD in pregnancy reduced later‐life endothelium‐dependent vasodilation in carotid arteries (−15.24±3.27%), which was mediated via prostaglandin H synthase 2. There were no differences in vasodilation between CD and HCD postpartum rats in the mesenteric arteries, coronary arteries, or aortas. Vasoconstriction to phenylephrine increased in carotid arteries (61.02±21.48%) and reduced in aortas (−23.24±6.19%) of the HCD postpartum group versus CD dams, without differences in mesenteric and coronary arteries. The increased vasoconstriction in carotid arteries was due to lower nitric oxide modulation of constriction. Moreover, carotid artery myogenic response was reduced (−37.68±10.07%) and stiffness was increased (19.67±6.21%) in the HCD postpartum rats compared with CD along with decreased elastin density (−20.85±4.52%). The impact of the HCD on vascular function did not occur in age‐matched never‐pregnant female rats.

Conclusions

Excessive hypercholesterolemia in pregnancy impairs later‐life maternal vascular function in rats with varying impacts across different vascular beds. Understanding mechanisms for
pregnancy‐specific
excessive hypercholesterolemia provides avenues for targeted intervention strategies to reduce the burden of cardiovascular disease in women who had a complicated pregnancy.
Open and Citizen Science in Light of New European Research Policies
Authors: Adam Frane , Gorišek Maruša 
Published: February 2025

Abstract
This article discusses the meaning of open science, and in particular the concept of citizen science, in a broader socio-political and scientific context. The authors highlight the ambivalence of these concepts and the lack of critical reflection on the possible (unwanted) negative implications of the establishment of these ideas. The authors address these issues using an international comparative analysis based primarily on documentation and secondary data analysis. Research approaches in the sense of open science and citizen science can, in many cases, be useful for researchers as well as for cognitively active citizens. They can enable the enrichment of knowledge and the potential for (social) innovation. However, there are also risks and unwanted side effects that diminish the relevance and status of scientific research. It is particularly dangerous to create illusions about the potential of ad hoc citizen science projects and their outstanding, immediate results. The campaign for open science may serve as a cover-up for some of the problems and anomalies in the realm of science. The authors also see danger in the potential erosion of the autonomy of science and diverting attention from some of the more pressing problems in science.
Exploring consumer perception of edible insects in Korea using text mining
Authors: Kang K. , Kim Y. 
Published: February 2025

Abstract
Food security is a critical issue derived from the limitations of protein production systems, promoting the exploration of edible insects as alternative protein sources. While perception surveys are essential to a research planning process to address entomophobia, they are costly and time-consuming. Analysing text data on social media using text mining has been suggested for innovative perception surveys in the era of big data. This study analysed articles about edible insects from blogs and online communities to understand the Korean public’s perception. The comprehensive results of word frequency and similarity analysis showed that Koreans are steadily interested in edible insects as future food and in farms, industries, and businesses of edible insects in Korea. Additionally, the public’s perception of health benefits or drying processing methods of edible insects was identified over the years. Results of topic modeling, though less intuitive than word frequency and similarity analysis, provided complementary insights such as future, alternative, health effect, usage, and application of edible insects. The text mining results (TMR) were validated because similar results on TMR and perception survey results (PSR) were obtained. TMR provided insights into unpredictable words or topics, such as domestic markets and health issues, which were not captured by PSR. In conclusion, the public’s perception and new meanings of edible insects were derived using text mining, and the applicability of this novel and cost-effective method as a perception survey was confirmed through this research.
New Insights into Middle Nubian Ceramic Traditions at Elephantine: An Attempt for a Better Understanding of Cultural Complexities in Upper Egypt and Nubia
Authors: Schröder Marie-Kristin 
Published: February 2025

Abstract
The Middle Nubian ‘C-Group’, ‘Kerma’, and ‘Pan-Grave’ cultures have commonly been believed to be contemporaneous for most of their occurrence, but recent research on Nubian-style ceramics from the settlement at Elephantine Island indicate that this contemporaneity must be reconsidered. This paper presents the results of the ceramic analysis of the Nubian-style corpus from recent excavations in the Northwestern town at Elephantine with a focus on intra- and intercultural ceramic finds. Although site-specific pottery formations at Elephantine allow for a more neutral way of addressing ceramic assemblages, comparisons with ceramics from sites in Lower and Upper Nubia enable us to differentiate between Nubian traditions. The domestic and funerary ceramic assemblages of the C-Group culture are significant for redefining the cultural complexities of the Middle Nubian traditions. This paper sheds light on the ceramic tradition of the C-Group in comparison to those of the Pan-Grave horizon, Kerma culture as well as pharaonic traditions.
Nubian Style Pottery from the New Kingdom Town of Sai Island
Authors: Budka Julia 
Published: February 2025

Abstract
The pottery corpus from the city on Sai Island, one of the characteristic colonial towns in New Kingdom Nubia, comprises a majority of Egyptian style vessels and Nubian style ceramics as well as ‘hybrid’ pieces. This paper presents the Eighteenth Dynasty Nubian pottery from Sai city, focussing primarily on quantities, shapes, wares and parallels from various sites in context, and discusses its social and cultural implications. A key concern is how much Sai represents an elite urban phenomenon that differs from rural contexts in the hinterland of the city.
The Nubian style pottery as an integral part of the corpus of Sai attests to social practices of a local group with a specific cultural identity. The community practices reflected in the pottery show that the legacy of the Kerma empire was never completely abandoned but adapted in relation to the new political, social and religious circumstances in a colonial context.
Fuzzy Boundaries or Hard Borders? Cultural Groupings in Second Millennium bc Nubia from the View of Linguistic Evidence
Authors: Cooper Julien 
Published: February 2025

Abstract
The region of Sudan and Nubia has always been witness to a complicated nexus of linguistic groupings, frequently exhibiting episodes of linguistic shifts, migration, and extinction. From Nilo-Saharan languages like Meroitic, to Afroasiatic languages like Beja, the region of the Second Millennium bce Middle Nile was certainly not homogenous ethno-linguistically. Linguistic enigmas provide further confusion, like the unknown languages of Lower Nubia that correlate to A- and C-Group material horizons. This paper describes the limits of the evidence in organizing linguistic groupings of ancient Nubia and critiques the issue as to whether these linguistic blocs correlate to geographic boundaries of specific material cultures. Does homogeneity in the archaeological record demonstrate similar homogeneity in linguistic identity? How do we expect nomadic pastoralists, seasonal movements, and migrations to affect this linguistic map? With a focus on pragmatic arguments and the use of later linguistic evidence, this paper reflects on the peopling of the Middle Nile region.
‘Constantly invalidated by an intolerant and uncaring world’: Perceived etiology of suicidal thoughts among transgender, nonbinary, and gender expansive black, indigenous, and other people of color
Authors: Gamio Cuervo Álvaro , Del Rio Michelle 
Published: February 2025

Background: Transgender, nonbinary, gender-expansive (TNGE) Black, Indigenous, and Other People of Color (BIPOC) have one of the highest rates of suicidal ideation and suicide attempts. As recommended by the cultural framework of suicide, examining culturally relevant lay beliefs and attitudes, such as community perspectives on where suicidal ideation originates, is integral for suicide prevention. Doing so may aide in identifying avenues of support for TNGE BIPOC with chronic suicidal ideation. Aims: This study aimed to examine how TNGE BIPOC community members perceive the etiological foundation of suicidal ideation. Method: Short-answer responses were collected from 110 participants in a national cross-sectional survey within the United States. Data were analyzed utilizing a directed content analysis approach to thematically categorize etiological factors. Result: Participants described four major areas regarding perceived etiology of suicidal thoughts including: (1) chronic trauma and stress; (2) societal and cultural expectations; (3) biological factors; and (4) structural oppression. The most salient etiological factor was structural oppression which was endorsed by 60% of the sample. Conclusions: Results suggest that experiences of structural oppression should be incorporated in assessing TNGE BIPOC clients’ beliefs about suicide and suicide prevention, given its relative saliency within this sample. Further research is needed to adequately understand how cumulative stress and social-cultural expectations impact the development of suicidal ideation among TNGE BIPOC.
Welcome Refugees? The Asylum System in Spain
Authors: Iglesias Juan , Bermejo Rut 
Published: February 2025

The Spanish asylum system and refugee reception program demonstrate persistent problems involving initial access to asylum and the processing of applications; access to assistance from the reception system; and the process of integration of asylum seekers, which is characterized by social segregation. This article analyzes these issues and seeks to explain them by looking beyond the immediate circumstances of the substantial increase in applications, mainly from Latin Americans, that has taken place in Spain since 2015. The deficiencies of the asylum system are explained in terms of the restrictive refugee paradigm employed by Spain and the European Union as a whole, as well as the development of a restricted, isolated reception model focused more on the initial assistance process than on social integration. Our analysis is based on two recent studies and provides empirical evidence in an area of study that has been scarcely addressed in Spain. El sistema de asilo español y su programa de acogida presentan problemas persistentes relacionados con el acceso al asilo y la tramitación de las solicitudes, el acceso y la intervención del sistema de acogida, y los procesos de integración de los solicitantes, marcados por la segregación social. El artículo analiza dichos problemas, y trata de explicarlos yendo más allá de la coyuntura del fuerte crecimiento de las solicitudes ocurrido en España desde el año 2015, protagonizado principalmente por solicitantes latinoamericanos. Se apunta, así, que los déficits del asilo se explican por la existencia de un paradigma restrictivo del refugio en España y en la UE, y el desarrollo de un modelo de acogida restringido, aislado y centrado en el proceso de atención inicial más que en la integración. El análisis se apoya en dos investigaciones realizadas recientemente, aportando evidencia empírica a un área de estudio poco estudiada en España.
Characterization of the coir fiber from different coconut varieties to enhance the performance of coir fiber-reinforced natural rubber composites
Authors: Fernando Jayakodi A. K. M. , Yalegama Chandi , Fernando Nandana , Samarakoon Upeka K. , Edirisinghe Dilhara , Sampath Manju 
Published: February 2025

The manufacture of composite materials reinforced with bristle fiber that possess distinct properties is highly attractive for novel applications. The quality variations in coir fiber-reinforced rubber composites (CFRC) are mainly affected by several factors, including the type of rubber matrix used, the interfacial adhesion between the coir fiber and the rubber matrix, the fiber length, and fiber loading. The objectives of this study were to assess and characterise coir fibers extracted from diverse Sri Lankan coconut varieties to identify high-quality coir fiber suitable for the fabrication of high-performance coir fiber-reinforced rubber composites, and the optimal range of coir fiber length and loading was investigated to maximize the mechanical properties of the composites. In this research, the extracted bristle fiber from different coconut varieties was examined for distinct properties and chemical composition. The varying lengths, specifically ranging from 0 to 0.5 mm and 0.5-1.0 mm of fiber from selected coconut varieties, were used for making CFRC. Different loadings of the selected range of coir fiber were used for partial replacement of carbon black in CFRC. Results showed that the Kamandala and Tall x Tall varieties had significantly high tensile strengths, with the Tall x Tall variety selected due to its superior mechanical properties and high abundance. The replacement of carbon black filler in natural rubber composites with 10 phr of coir fiber obtained from the Tall x Tall variety, with a length range of 0 to 0.5 mm, possessing coir-to-carbon black weight ratios of 10/40 phr, demonstrated superior properties in terms of tensile strength, tear strength, and elongation compared to composites containing 10 phr of coir fiber with a length range of 0.5-1 mm and other coir fiber to carbon black ratios. These findings provide insightful information for the development of composite materials and promote the sustainable and responsible utilization of coconut resources.
Asian family members’ participation in advance care planning: An integrative review
Authors: Pan Jing-Da , Ho Ka Yan , Guan Gui-fen , Chang Min-Min , Tan Cui-Rong , Qiu Xin-Yan , Liu Hong-Li , Lin Ke-Lan , Xu Wen-Ting , Pan Shan , Liu Qi , Mao Ting , Lam Katherine Ka Wai , Ling Dong-Lan 
Published: February 2025

Background: Family members play a pivotal role in advance care planning for patients with life-limiting illnesses, particularly in Asia, where cultural values stress family-centeredness and paternalism. Aim: To synthesize the evidence pertaining to the extent of Asian family members’ involvement in advance care planning. Design: An integrative review was conducted. Data sources: Data sources included MEDLINE, EMBASE, CINAHL, Web of Science, PubMed, Wan Fang, China National Knowledge Infrastructure databases, Google Scholar, and Open Gray. Results: 21 studies were included. The willingness of Asian family members to participate in advance care planning is high, while their actual engagement remains low. Based on the barriers, facilitators, and Asian family members’ roles influencing participation identified in our study, a six-dimensional conceptual model was developed: Asian family members’ roles, problem-solving skills, communication, affective responsiveness, affective participation, and controlling behavior in advance care planning. Barriers to effective participation were identified: inadequate advance care planning legislation, insufficient public education, and influences from Confucianism or traditional beliefs. Additionally, filial piety was shown to have a paradoxical effect on Asian family members’ participation in advance care planning in Asian countries. Conclusions: This study proposes a culturally sensitive model to illustrate family members’ participation in advance care planning in Asia. This lays a foundation to develop culturally specific interventions to enhance family participation in advance care planning in the future. We recommend that Asian governments should enact legislations, enhance public education, and incorporate cultural characteristics into relevant policy frameworks to foster greater family involvement in advance care planning.
Changing Time Representation in Microsimulation Models
Authors: Wong Eric Kai-Chung , Isaranuwatchai Wanrudee , Sale Joanna E. M. , Tricco Andrea C. , Straus Sharon E. , Naimark David M. J. 
Published: February 2025

Background In microsimulation models of diseases with an early, acute phase requiring short cycle lengths followed by a chronic phase, fixed short cycles may lead to computational inefficiency. Examples include epidemic or resource constraint models with early short cycles where long-term economic consequences are of interest for individuals surviving the epidemic or ultimately obtaining the resource. In this article, we demonstrate methods to improve efficiency in such scenarios. Furthermore, we show that care must be taken when applying these methods to epidemic or resource constraint models to avoid bias. Methods To demonstrate efficiency, we compared the model runtime among 3 versions of a microsimulation model: with short fixed cycles for all states (FCL), with dynamic cycle length (DCL) defined locally for each state, and with DCL features plus a discrete-event-like hybrid component. To demonstrate bias mitigation, we compared discounted lifetime costs for 3 versions of a resource constraint model: with a fixed horizon where simulation stops, with a fixed entry horizon beyond which new individuals could not enter the model, and with a fixed entry horizon plus a mechanism to maintain a constant level of competition for the resource after the horizon. Results The 3 versions of the microsimulation model had average runtimes of 515 (95% credible interval [CI]: 477 to 545; FCL), 2.70 (95% CI: 1.48 to 2.92; DCL), and 1.45 (95% CI: 1.26 to 2.61; DCL-pseudo discrete event simulation) seconds, respectively. The first 2 resource constraint versions underestimated costs relative to the constant competition version: $20,055 (95% CI: $19,000 to $21,120), $27,030 (95% CI: $24,680 to $29,412), and $33,424 (95% CI: $27,510 to $44,484), respectively. Limitations The magnitude of improvements in efficiency and reduction in bias may be model specific. Conclusion Changing time representation in microsimulation may offer computational advantages. Highlights Short cycle lengths may be required to model the acute phase of an illness but lead to computational inefficiency in a subsequent chronic phase in microsimulation models. A solution is to create state-specific cycle lengths so that cycle lengths change dynamically as the simulation progresses. Computational efficiency can be enhanced further by using a hybrid model containing discrete-event-simulation-like features. Hybrid models can efficiently handle events subsequent to exit from an epidemic or resource constraint model provided steps are taken to mitigate potential bias.