bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of term premature rupture of membrane: case-control study in Saint Paul’s Millennium Medical College Hospital, Addis Ababa, Ethiopia
Authors: daniel Zelele , Tantu Temesgen , Zewdu Dereje , Mekuria Thomas , Yehualashet Tsion , Gunta Muluken , Wondosen Mekete 
Published: July 2023

Abstract
Background
The term premature rupture of the membranes is the rupture of the membranes before the onset of labor beyond 37 weeks of gestation. Several factors, including obstetric, gynecologic, socioeconomic, and medical, are identified as potential risk factors. This clinical event has detrimental maternal and neonatal complications.

Objectives
This study aimed to investigate the determinants of the term premature rupture of the membranes in Ethiopia.

Methods
This institution-based unmatched case-control study was conducted on 246 women admitted to Saint Paul’s hospital millennium medical college from October 2019 to January 2020 (82 cases and 164 controls). Data were collected using an interviewer-based questionnaire and data extraction tools, and data were entered using Epi data 3.1 and analyzed using SPSS 20. The association between independent variables and premature rupture of the membrane was estimated using an odds ratio with 95% confidence intervals and P-value < 0.05.

Results
Factors like a history of vaginal discharge (AOR 3.508;95% CI:1.595.7.716), place of Antenatal care follow-up (health center and Mercy Ethiopia) (AOR 5.174;95% CI:2.165,12.362), the previous history of rupture of membrane (AOR 9.955;95% CI:3.265,20.35), and gestational age (AOR 3.018;95% CI:1.338,6.811) were associated with term premature rupture of membrane. There were more maternal and neonatal complications, including puerperal sepsis, wound infection, anemia/PPH, a hospital stays of more than seven days, clinical amnionitis, neonatal hypoglycemia, early onset neonatal sepsis, and respiratory distress encountered by women who presented with premature rupture of membrane.

Conclusion
Proper screening, close monitoring, and early interventions in those mothers with identified risk factors would help to reduce its negative consequences. Moreover, the provision of continuous professional skill development and improving the quality of ANC service is needed.
The use of GRADE-CERQual in qualitative evidence synthesis: an evaluation of fidelity and reporting
Authors: Wainwright Megan , Zahroh Rana Islamiah , Tunçalp Özge , Booth Andrew , Bohren Meghan A. , Noyes Jane , Cheng Weilong , Munthe-Kaas Heather , Lewin Simon 
Published: July 2023

Abstract
Background
GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative Research) is a methodological approach to systematically and transparently assess how much confidence decision makers can place in individual review findings from qualitative evidence syntheses. The number of reviews applying GRADE-CERQual is rapidly expanding in guideline and other decision-making contexts. The objectives of this evaluation were, firstly, to describe the uptake of GRADE-CERQual in qualitative evidence synthesis by review authors and, secondly, to assess both reporting of and fidelity to the approach.

Methods
The evaluation had two parts. Part 1 was a citation analysis and descriptive overview of the literature citing GRADE-CERQual. Authors worked together to code and chart the citations, first by title and abstract and second by full text. Part 2 was an assessment and analysis of fidelity to, and reporting of, the GRADE-CERQual approach in included reviews. We developed fidelity and reporting questions and answers based on the most recent guidance for GRADE-CERQual and then used NVivo12 to document assessments in a spreadsheet and code full-text PDF articles for any concerns that had been identified. Our assessments were exported to Excel and we applied count formulae to explore patterns in the data. We employed a qualitative content analysis approach in NVivo12 to sub-coding all the data illustrating concerns for each reporting and fidelity criteria.

Results
233 studies have applied the GRADE-CERQual approach, with most (n = 225, 96.5%) in the field of health research. Many studies (n = 97/233, 41.6%) were excluded from full fidelity and reporting assessment because they demonstrated a serious misapplication of GRADE-CERQual, for example interpreting it as a quality appraisal tool for primary studies or reviews. For the remaining studies that applied GRADE-CERQual to assess confidence in review findings, the main areas of reporting concern involved terminology, labelling and completeness. Fidelity concerns were identified in more than half of all studies assessed.

Conclusions
GRADE-CERQual is being used widely within qualitative evidence syntheses and there are common reporting and fidelity issues. Most of these are avoidable and we highlight these as gaps in knowledge and guidance for applying the GRADE-CERQual approach.
Intimate partner violence against HIV-Positive women on ART follow-up and associated factors in public health facilities of western Ethiopia
Authors: Biranu Shibiru , Getachew Motuma , Kejela Gemechu , Kifilu Chaltu 
Published: July 2023

Abstract
Introduction
Intimate partner violence is the most pervasive but less recognized problem which affects millions of women world. It is more common among marginalized individuals including women affected by HIV. However, there is limited information regarding this problem among HIV-Positive Women in Ethiopia. Thus, the study was aimed to assess the magnitude and factors associated with intimate partner violence among HIV positive women in western Ethiopia.

Methods
A facility-based cross-sectional study was conducted among HIV-positive women on ART follow-up in Nekemte town. A total of 420 women were selected by the simple random sampling technique and an interviewer-administered questionnaire was used for data collection. The data were entered to EpiData version 3.1 and analyzed by SPSS version 20. Univariable and mult- variable logistic regression analysis with their corresponding odds ratio (95%CI) were computed, and statistical significance was declared at p < 0.05.

Results
The magnitude of intimate partner violence among HIV-positive Women during Lifetime and since diagnosed with HIV was 49.29%, [(95% CI: 44.3–53.6%)] and 41.67%, [(95% CI: 37.1–45.7%)] respectively. Skipping daily ART medication ≥ 6 times/month [AOR = 3.56; (95% CI 1.18, 10.74)], experiencing controlling behavior by a partner[AOR = 6.37; (95% CI 3.26, 12.44)], women inter-parental witness of violence [AOR = 1.74; (95% CI 1.09, 2.79)], women having favorable attitude that justify wife-beating [AOR = 1.76; (95% CI 1.06, 2.94)]and non-disclosure of test result to partner [AOR 0.38; (95% CI 0.22, 0.66)] were factors associated with intimate partner violence since diagnosed with HIV.

Conclusion
The magnitude of intimate partner violence among HIV-positive Women on ART follow-up was found to be high in the study area. Therefore, integrating intimate partner violence victim screening with ART services, empowering HIV-positive women, and increasing their awareness of sexual and reproductive rights is needed.
Data from the European registry for patients with McArdle disease (EUROMAC): functional status and social participation
Authors: Karazi Walaa , Scalco Renata S. , Stemmerik Mads G. , Løkken Nicoline , Lucia Alejandro , Santalla Alfredo , Martinuzzi Andrea , Vavla Marinela , Reni Gianluigi , Toscano Antonio , Musumeci Olimpia , Kouwenberg Carlyn V. , Laforêt Pascal , Millán Beatriz San , Vieitez Irene , Siciliano Gabriele , Kühnle Enrico , Trost Rebecca , Sacconi Sabrina , Durmus Hacer , Kierdaszuk Biruta , Wakelin Andrew , Andreu Antoni L. , Pinós Tomàs , Marti Ramon , Quinlivan Ros , Vissing John , Voermans Nicol C. ,   EUROMAC Consortium
Published: July 2023

Abstract
Background
The European registry for individuals with GSD5 and other muscle glycogenosis (EUROMAC) was launched to register rare muscle glycogenosis in Europe, to facilitate recruitment for research trials and to learn about the phenotypes and disseminate knowledge about the diseases. A network of twenty collaborating partners from eight European countries and the US contributed data on rare muscle glycogenosis in the EUROMAC registry.

Methods
Following the initial report on demographics, neuromuscular features and comorbidity (2020), we here present the data on social participation, previous and current treatments (medication, supplements, diet and rehabilitation) and limitations. Furthermore, the following questionnaires were used: Fatigue severity scale (FSS), WHO Disability Assessment Scale (DAS 2.0), health related quality of life (SF36) and International Physical Activity Questionnaire (IPAQ).

Results
Of 282 participants with confirmed diagnoses of muscle glycogenosis, 269 had GSD5. Of them 196 (73%) completed all questionnaires; for the others, the data were incomplete. The majority, 180 (67%) were currently working. Previous medical treatments included pain medication (23%) and rehabilitation treatment (60%). The carbohydrate-rich diet was reported to be beneficial for 68%, the low sucrose diet for 76% and the ketogenic diet for 88%. Almost all participants (93%) reported difficulties climbing stairs. The median FSS score was 5.22, indicating severe fatigue. The data from the WHODAS and IPAQ was not of sufficient quality to be interpreted.

Conclusions
The EUROMAC registry have provided insight into the functional and social status of participants with GSD5: most participants are socially active despite limitations in physical and daily life activities. Regular physical activity and different dietary approaches may alleviate fatigue and pain.
Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)
Authors: Malhotra Akash , Nonyane Bareng Aletta Sanny , Shirey Evan , Mulder Christiaan , Hippner Piotr , Mulatu Fiseha , Ratshinanga Andani , Mitiku Petros , Cohn Silvia , Conradie Gideon , Chihota Violet , Chaisson Richard E. , Churchyard Gavin J. , Golub Jonathan , Dowdy David , Sohn Hojoon , Charalambous Salome , Bedru Ahmed , Salazar-Austin Nicole 
Published: July 2023

Abstract
Background
Each year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in preventing TB but remains poorly implemented for household child contacts. Home-based child contact management and TPT services may improve access to care. In this study, we aim to evaluate the effectiveness and cost-effectiveness of home-based contact management with TPT initiation in two TB high-burden African countries, Ethiopia and South Africa.

Methods
This pragmatic cluster randomized trial compares home-based versus facility-based care delivery models for contact management. Thirty-six clinics with decentralized TB services (18 in Ethiopia and 18 in South Africa) were randomized in a 1:1 ratio to conduct either home-based or facility-based contact management. The study will attempt to enroll all eligible close child contacts of infectious drug-sensitive TB index patients diagnosed and treated for TB by one of the study clinics. Child TB contact management, including contact tracing, child evaluation, and TPT initiation and follow-up, will take place in the child’s home for the intervention arm and at the clinic for the control arm. The primary outcome is the cluster-level ratio of the number of household child contacts less than 15 years of age in Ethiopia and less than 5 years of age in South Africa initiated on TPT per index patient, comparing the intervention to the control arm. Secondary outcomes include child contact identification and the TB prevention continuum of care. Other implementation outcomes include acceptability, feasibility, fidelity, cost, and cost-effectiveness of the intervention.

Discussion
This implementation research trial will determine whether home-based contact management identifies and initiates more household child contacts on TPT than facility-based contact management.

Trial registration
NCT04369326. Registered on April 30, 2020.
Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review
Authors: Schlesinger Naomi , Pillinger Michael H. , Simon Lee S. , Lipsky Peter E. 
Published: July 2023

Abstract
Objectives
The objective of this systematic review was to assess the effects of interleukin-1β (IL-1β) inhibitors on gout flares.

Methods
Studies published between 2011 and 2022 that evaluated the effects of IL-1β inhibitors in adult patients experiencing gout flares were eligible for inclusion. Outcomes including pain, frequency and intensity of gout flares, inflammation, and safety were assessed. Five electronic databases (Pubmed/Medline, Embase, Biosis/Ovid, Web of Science and Cochrane Library) were searched. Two independent reviewers performed study screening, data extraction and risk of bias assessments (Cochrane Risk of Bias Tool 2 for randomised controlled trials [RCTs] and Downs and Black for non-RCTs). Data are reported as a narrative synthesis.

Results
Fourteen studies (10 RCTs) met the inclusion criteria, with canakinumab, anakinra, and rilonacept being the three included IL-1β inhibitors. A total of 4367 patients with a history of gout were included from the 14 studies (N = 3446, RCTs; N = 159, retrospective studies [with a history of gout]; N = 762, post hoc analysis [with a history of gout]). In the RCTs, canakinumab and rilonacept were reported to have a better response compared to an active comparator for resolving pain, while anakinra appeared to be not inferior to an active comparator for resolving pain. Furthermore, canakinumab and rilonacept reduced the frequency of gout flares compared to the comparators. All three medications were mostly well-tolerated compared to their comparators.

Conclusion
IL-1β inhibitors may be a beneficial and safe medication for patients experiencing gout flares for whom current standard therapies are unsuitable.

Review protocol registration
PROSPERO ID: CRD42021267670.
Eating disorder risk in adolescent and adult female athletes: the role of body satisfaction, sport type, BMI, level of competition, and training background
Authors: Borowiec Joanna , Banio-Krajnik Adrianna , Malchrowicz-Mośko Ewa , Kantanista Adam 
Published: July 2023

Abstract
Background
Eating disorders negatively influence athletes’ health and performance. To achieve a high level of performance and conform to cultural expectations regarding an athletic body type, female athletes often restrict their diets, which can lead to eating disorders. In addition to factors related to the sports environment, adolescent athletes are subject to changes caused by the maturation process. Therefore, the same factors may have different effects on eating disorder risk among adolescent and adult athletes. This study examined the relationship between eating disorder risk, specific aspects of the sports environment (sport type, level of competition [national and international], and training background), and individual aspects (body satisfaction and body mass index) in two groups of athletes: adolescents and adults.

Methods
The sample included 241 highly trained female athletes aged 12–30 years (M = 20.68, SD = 4.45) recruited from different sports clubs in Poland. The subgroup of adolescents consisted of 82 athletes, while the number of adult athletes was 159. The Eating Attitudes Test questionnaire was used to assess the eating disorder risk among the athletes. Body satisfaction was measured using the Feelings and Attitudes Toward Body Scale incorporated into the Body Investment Scale.

Results
Eating disorder risk was prevalent among 14.6% of the adolescent and 6.9% of the adult athletes. Significant associations between eating disorder risk and the studied variables were noted only among adolescent athletes. Univariate logistic regression analysis revealed that the occurrence of eating disorder risk was associated with participation in lean non-aesthetic sports (OR = 11.50, 95% CI: 3.58–37.09). Moreover, eating disorder risk was associated with athletes’ lower body satisfaction (OR = 0.80, 95% CI: 0.70–0.92). Body mass index was not included in the final regression model.

Conclusions
The study indicated that eating disorder risk in adolescent female athletes was related to sport type and body satisfaction. The findings showed that, in adolescent athletes, eating disorder risk was the most associated with practicing lean non-aesthetic sports. Coaches and athletes should be aware that eating disorder risk increases among individuals with a lower body image.
Understanding the social inclusion needs of people living in mental health supported accommodation
Authors: Eager Sharon , Killaspy Helen , C Joanna , Mezey Gillian , Downey Megan , Lloyd-Evans Brynmor 
Published: July 2023

AbstractObjectivesTo identify the social inclusion needs that were (i) most commonly identified and (ii) most and least commonly prioritised as support planning goals for mental health service users living in supported accommodation, using the online Social Inclusion Questionnaire User Experience (SInQUE). We qualitatively examined mental health supported accommodation staff and servicer users’ views on barriers to offering support with two less commonly prioritised areas: help finding a partner and feeling less lonely.MethodsAnonymous SInQUE data were collected during a completed study in which we developed and tested the online SInQUE. Four focus groups were conducted with mental health supported accommodation staff (N = 2) and service users (N = 2).ResultsThe most common social inclusion needs identified by service users (N = 31) were leisure activities, finding transport options, and feeling less lonely. Of the needs identified, those that service users and staff least frequently prioritised as support planning goals were having company at mealtimes, getting one’s own furniture, feeling less lonely, help with finances, and help finding a partner. In the focus groups, staff and service users identified barriers to helping with loneliness and finding a partner which related to staff and service users themselves, supported accommodation services, and wider societal factors.
Dual stochastic descriptions of streamflow dynamics under model ambiguity through a Markovian embedding
Authors: Yoshioka Hidekazu , Yoshioka Yumi 
Published: July 2023

AbstractHamilton–Jacobi–Bellman equation (HJBE) and backward stochastic differential equation (BSDE) are the two faces of stochastic control. We explore their equivalence focusing on a system of self-exciting and affine stochastic differential equations (SDEs) arising in streamflow dynamics. Our SDE is a finite-dimensional Markovian embedding of an infinite-dimensional jump-driven process called the superposition of continuous-state branching processes (a supCBI process). We formulate new ergodic control problems to evaluate the worst-case streamflow discharge in the long run and derive their HJBEs and ergodic BSDEs. The constant ambiguity aversion classically used in assessing model ambiguity must be modified in our case so that the optimality equations become well-posed. With a suitable modification of the ambiguity-aversion coefficient depending on the distributed reversion speed, we demonstrate that the solutions to the optimality equations are equivalent to each other in the sense that they lead to the same result. Finally, we apply the proposed framework to the computation of realistic cases with an existing record of discharge through a numerical Markovian embedding.
Deer antler renewal gives insights into mammalian epimorphic regeneration
Authors: Li Chunyi 
Published: July 2023

AbstractDeer antlers are the only known mammalian organ that, once lost, can fully grow back naturally. Hence, the antler offers a unique opportunity to learn how nature has solved the problem of mammalian epimorphic regeneration (EpR). Comprehensive comparisons amongst different types of EpR reveal that antler renewal is fundamentally different from that in lower vertebrates such as regeneration of the newt limb. Surprisingly, antler renewal is comparable to wound healing over a stump of regeneration-incompetent digit/limb, bone fracture repair, and to a lesser extent to digit tip regeneration in mammals. Common to all these mammalian cases of reaction to the amputation/mechanical trauma is the response of the periosteal cells at the distal end/injury site with formation of a circumferential cartilaginous callus (CCC). Interestingly, whether the CCC can proceed to the next stage to transform to a blastema fully depends on the presence of an interactive partner. The actual form of the partner can vary in different cases with the nail organ in digit tip EpR, the opposing callus in bone fracture repair, and the closely associated enveloping skin in antler regeneration. Due to absence of such an interactive partner, the CCC of a mouse/rat digit/limb stump becomes involuted gradually. Based on these discoveries, we created an interactive partner for the rat digit/limb stump through surgically removal of the interposing layers of loose connective tissue and muscle between the resultant CCC and the enveloping skin after amputation and by forcefully bonding two tissue types tightly together. In so doing partial regeneration of the limb stump occurred. In summary, if EpR in humans is to be realized, then I envisage that it would be more likely in a manner akin to antler regeneration rather to that of lower vertebrates such as newt limbs.
Optimizing quasi-cyclic spatially coupled LDPC codes by eliminating harmful objects
Authors: Battaglioni Massimo , Chiaraluce Franco , Baldi Marco , Pacenti Michele , Mitchell David G. M. 
Published: July 2023

AbstractIt is well known that some harmful objects in the Tanner graph of low-density parity-check (LDPC) codes have a negative impact on their error correction performance under iterative message-passing decoding. Depending on the channel and the decoding algorithm, these harmful objects are different in nature and can be stopping sets, trapping sets, absorbing sets, or pseudocodewords. Differently from LDPC block codes, the design of spatially coupled LDPC codes must take into account the semi-infinite nature of the code, while still reducing the number of harmful objects as much as possible. We propose a general procedure, based on edge spreading, enabling the design of good quasi-cyclic spatially coupled LDPC (QC-SC-LDPC) codes. These codes are derived from quasi-cyclic LDPC (QC-LDPC) block codes and contain a considerably reduced number of harmful objects with respect to the original QC-LDPC block codes. We use an efficient way of enumerating harmful objects in QC-SC-LDPCCs to obtain a fast algorithm that spans the search space of potential candidates to select those minimizing the multiplicity of the target harmful objects. We validate the effectiveness of our method via numerical simulations, showing that the newly designed codes achieve better error rate performance than codes presented in previous literature.