bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni
Authors: Bu Lijing , Lu Lijun , Laidemitt Martina R. , Zhang Si-Ming , Mutuku Martin , Mkoji Gerald , Steinauer Michelle , Loker Eric S. 
Published: March 2023

BackgroundBiomphalaria pfeifferiis the world’s most widely distributed and commonly implicated vector snail species for the causative agent of human intestinal schistosomiasis,Schistosoma mansoni. In efforts to controlS.mansonitransmission, chemotherapy alone has proven insufficient. New approaches to snail control offer a way forward, and possible genetic manipulations of snail vectors will require new tools. Towards this end, we here offer a diverse set of genomic resources for the important African schistosome vector,B.pfeifferi.Methodology/Principal findingsBased largely on PacBio High-Fidelity long reads, we report a genome assembly size of 772 Mb forB.pfeifferi(Kenya), smaller in size than known genomes of other planorbid schistosome vectors. In a total of 505 scaffolds (N50 = 3.2Mb), 430 were assigned to 18 large linkage groups inferred to represent the 18 known chromosomes, based on whole genome comparisons withBiomphalaria glabrata. The annotatedB.pfeifferigenome reveals a divergence time of 3.01 million years withB.glabrata, a South American species believed to be similar to the progenitors ofB.pfeifferiwhich undertook a trans-Atlantic colonization < five million years ago.Conclusions/SignificanceThe genome for this preferentially self-crossing species is less heterozygous than related species known to be preferential out-crossers; its smaller genome relative to congeners may similarly reflect its preference for selfing. Expansions of gene families with immune relevance are noted, including theFReDgene family which is far more similar in its composition toB.glabratathan toBulinus truncatus, a vector forSchistosoma haematobium. Provision of this annotated genome will help better understand the dependencies of trematodes on snails, enable broader comparative insights regarding factors contributing to susceptibility/ resistance of snails to schistosome infections, and provide an invaluable resource with respect to identifying and manipulating snail genes as potential targets for more specific snail control programs.
Adapting waterpipe-specific pictorial health warning labels to the Tunisian context using a mixed method approach
Authors: Ben Mansour Nadia , Rejaibi Salsabil , Sassi Mahfoudh Asma , Ben Youssef Sarra , Ben Romdhane Habiba , Schmidt Michael , D. Ward Kenneth , Maziak Wasim , Asfar Taghrid 
Published: March 2023

Background
Waterpipe (WP) use is rapidly increasing among young people worldwide due to the widespread misperception that it is safer than cigarette smoking. Health warning labels (HWLs) can effectively communicate tobacco-related health risks but have yet to be developed for WP. This study aimed to optimize and adapt a set of 16 pictorial WP-specific HWLs, developed by an international Delphi study, to the Tunisian context. HWLs were grouped into four themes: WP health risks, WP harm to others, WP-specific harms, and WP harm compared to cigarettes.

Methods
Using a mixed method approach, we conducted ten focus groups combined with a survey among young WP users and nonusers (N = 63; age 18–34 years). In the survey, participants rated the HWLs on several communication outcomes (e.g., reaction, harm perception, effectiveness) and were then instructed to view all HWLs in each theme and rank them in the order of overall perceived effectiveness, from the most to the least effective. Afterward, participants provided in-depth feedback on HWLs and avenues for improvement. Mean effectiveness rating scores and percentages of participants’ top-ranked HWLs were calculated. Discussions were audio-taped, transcribed verbatim, and analyzed thematically.

Results
The top-ranked HWLs were those showing oral cancers, orally transmitted diseases, and a sick child. Focus group discussion illustrated that these selections were based on participants’ reactions to the direct impact of WP on a person’s physical appearance and evoking guilt over children’s exposure to WP smoke. Suggestions for improvement highlighted the need to use the local dialect and more affirmative statements (e.g., avoiding "may" or "can").

Conclusions
This study is the first in North Africa to attempt to advance HWLs policy as the World Health Organization recommended. The results of this study can be used as a basis for implementing WP-specific health messages in the Eastern Mediterranean Region.
Physiotherapists’ practice patterns for the diagnosis and management of patients with chronic contracted frozen shoulder in the United Arab Emirates
Authors: Alhammadi Mariam J. , Hegazy Fatma A. 
Published: March 2023

Background
Adhesive capsulitis or contracted shoulder, known as frozen shoulder, is a persistent painful condition that may last for more than three months. It is a common disease-causing morbidity that causes pain and loss of shoulder range of motion. Physical therapy is advocated for the restoration of a pain-free state and normal use of the upper extremity, along with other interventions.

Purpose
This study aimed to explore the level of current clinical practice for managing chronic contracted frozen shoulder (CCFS) among physiotherapy professionals in the United Arab Emirates (UAE) compared to well–established evidence-based practices, and to identify the most common therapy practiced in UAE to manage CCFS.

Method
This study was based on a cross-sectional quantitative analysis using an adapted questionnaire. The main themes of questions were the presence of a special interest in CCFS, management options, symptoms, diagnosis, referral, and best physiotherapy intervention recommendations. The results were analyzed using simple descriptive analyses, such as frequency, mean, and percentage of total responses; additionally, thematic and content analyses were performed for open-ended questions.

Results
Overall, 101 physiotherapy professionals participated in the survey: 62% female and 38% male; 59% were bachelors- and 36% masters-degree holders, respectively. In the closed ended question regarding the interest in CCFS, male physiotherapists (PTs) were more interested than females (82% vs. 68%). For the most common indication of CCFS, 76% of the participants selected “Limitation of movement" as the main indication. However, only 42% confirmed the presence of clinical protocols in their employment setting. In their opinion, the most effective therapies were patient education, superficial heat or cold, manual joint mobilization, and sustained stretching exercises.

Conclusion
A well-established professional competence exists among physiotherapists in the UAE to manage and treat patients with CCFS. The findings showed sufficient standard, theoretical, and practical knowledge among the study groups.
Factors correlated with pain after total knee arthroplasty: A systematic review and meta-analysis
Authors: Olsen Unni , Lindberg Maren Falch , Rose Christopher , Denison Eva , Gay Caryl , Aamodt Arild , Brox Jens Ivar , Skare Øystein , Furnes Ove , Lee Kathryn A. , Lerdal Anners 
Published: March 2023

Main objective
Systematically review and synthesize preoperative and intraoperative factors associated with pain after total knee arthroplasty (TKA) in patients with osteoarthritis.

Methods
Based on a peer-reviewed protocol, we searched Medline, Embase, CINAHL, Cochrane Library, and PEDro for prospective observational studies (January 2000 to February 2023) investigating factors associated with pain after TKA. The primary outcome was pain twelve months after TKA. Pain at three and six months were secondary outcomes. Multivariate random-effects meta-analyses were used to estimate mean correlation (95% CIs) between factors and pain. Sensitivity analysis was performed for each risk of bias domain and certainty of evidence was assessed.

Results
Of 13,640 studies, 29 reports of 10,360 patients and 61 factors were analysed. The mean correlation between preoperative factors and more severe pain at twelve months was estimated to be 0.36 (95% CI, 0.24, 0.47; P < .000; moderate-certainty evidence) for more catastrophizing, 0.15 (95% CI; 0.08, 0.23; P < .001; moderate-certainty evidence) for more symptomatic joints, 0.13 (95% CI, 0.06, 0.19; P < .001; very low-certainty evidence) for more preoperative pain. Mean correlation between more severe radiographic osteoarthritis and less pain was -0.15 (95% CI; -0.23, -0.08; P < .001; low-certainty evidence). In sensitivity analysis, the estimated correlation coefficient for pain catastrophizing factor increased to 0.38 (95% CI 0.04, 0.64). At six and three months, more severe preoperative pain was associated with more pain. Better preoperative mental health was associated with less pain at six months.

Conclusion and relevance
More pain catastrophizing, more symptomatic joints and more pain preoperatively were correlated with more pain, while more severe osteoarthritis was correlated with less pain one year after TKA. More preoperative pain was correlated with more pain, and better mental health with less pain at six and three months. These findings should be further tested in predictive models to gain knowledge which may improve TKA outcomes.
The spatial and temporal variation of fine particulate matter pollution in Ethiopia: Data from the Atmospheric Composition Analysis Group (1998–2019)
Authors: Shiferaw Ashenafie Bereded , Kumie Abera , Tefera Worku 
Published: March 2023

Background
Evidence suggests ambient fine particulate matter (PM2.5) is a risk factor for cardiovascular diseases, lung cancer morbidity and mortality, and all-cause mortality. Countries that implement strong policies are able to reduce ambient PM2.5 concentration. In Ethiopia, however, PM2.5 monitoring stations, laboratory technicians, and equipment are staggeringly limited. In this study, the spatial and temporal variation of PM2.5 in Ethiopia was assessed.

Methods
Satellite-based PM2.5 estimates, from the year 1998 to 2019, by Atmospheric Composition Analysis Group (ACAG) at a spatial resolution of 0.01° X 0.01° was used. The annual mean PM2.5 concentration for all administrative regions and zones in Ethiopia was extracted. The average mean from the twenty-two years was also calculated. The trend of PM2.5 concentration was graphed and quantitatively calculated using the Mann-Kendall test. The slope of the change over time was estimated using the Theil-Sen slope. At the zonal administration level, for the average annual mean, spatial dependency using univariate Global Moran’s I and clustering and outlier tests using Anselin Local Moran’s were performed.

Results
The country’s average annual mean PM2.5 concentration was 17 μgm-3. The Afar region had the highest concentration, 27.9 μgm-3. The Mann-Kendall S was positive and significant at p<0.001. The spatial distribution of satellite-based ambient PM2.5 concentration was non-random. Significant highest value clustering of ambient total PM2.5 concentration exists in the Afar, Eastern Tigray, and Eastern and Southeastern Amhara while the significant lowest value dispersing was observed in the Southern Oromia and Somali region.

Conclusion
At the national and regional levels, the annual mean ambient PM2.5 concentration is beyond the World Health Organization (WHO)-recommended level. The ambient PM2.5 concentration distribution is spatially dependent and significantly clustered in space. Installation of additional ground-based PM2.5 monitoring devices, particularly in regions where PM2.5 concentration is higher, is recommended. Validating satellite-based PM2.5 data with ground-based measurements in the country is also advised.
Prevalence of undernutrition and associated factors among adults taking antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis
Authors: Seid Awole , Seid Omer , Workineh Yinager , Dessie Getenet , Bitew Zebenay Workneh 
Published: March 2023

Background
Undernutrition (Body Mass Index < 18.5 kg/m2) is a common problem and a major cause of hospital admission for patients living with HIV. Though sub-Saharan Africa is the most commonly affected region with HIV and malnutrition, a meta-analysis study that estimates the prevalence and correlates of undernutrition among adults living with HIV has not yet been conducted. The objective of this study was to determine the pooled prevalence of undernutrition and associated factors among adults living with HIV/AIDS in sub-Saharan Africa.

Methods
Studies published in English were searched systematically from databases such as PubMed, Google Scholar, and gray literature, as well as manually from references in published articles. Observational studies published from 2009 to November 2021 were included. The data extraction checklist was prepared using Microsoft Excel and includes author names, study area, publication year, sample size, prevalence/odds ratio, and confidence intervals. The results were presented and summarized in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standard. Heterogeneity was investigated using the Q test, I2, τ2, τ and predictive interval. STATA version 17 was used to analyze the data. A meta-analysis using a random-effects model was used to determine the overall prevalence and adjusted odds ratio. The study has been registered in PROSPERO with a protocol number of CRD42021268603.

Results
In this study, a total of 44 studies and 22,316 participants were included. The pooled prevalence of undernutrition among adult people living with HIV (PLWHIV) was 23.72% (95% CI: 20.69–26.85). The factors associated with undernutrition were participants’ age (AOR = 0.5, 95% CI: 0.29–0.88), gender (AOR = 2.08, 95% CI: 0.22–20.00), World Health Organization (WHO) clinical stage (AOR = 3.25, 95% CI: 2.57–3.93), Cluster of Differentiation 4 (CD4 count) (AOR = 1.94, 95% CI: 1.53–2.28), and duration of ART (AOR = 2.32, 95% CI: 1.6–3.02).

Conclusion
The pooled prevalence of undernutrition among adult PLWHIV in sub-Saharan Africa remained high. WHO clinical stage, CD4 count, duration of ART treatment, age, and sex were found to be the factors associated with undernutrition. Reinforcing nutrition counseling, care, and support for adults living with HIV is recommended. Priority nutritional screening and interventions should be provided for patients with advanced WHO clinical stages, low CD4 counts, the male gender, younger age groups, and ART beginners.
HIV retesting for pregnant and breastfeeding women across maternal child health services in Nampula, Mozambique
Authors: Teasdale Chloe A. , Choy Michelle , Tsiouris Fatima , De Gusmao Eduarda Pimentel , Banqueiro Etelvino C. P. , Couto Aleny , Tibana Kwalila , Flowers Nicole , Urso Marilena , Vitale Mirriah , Abrams Elaine J. 
Published: March 2023

BackgroundRepeat HIV testing during pregnancy and breastfeeding identifies women with incident infections, those living with HIV who have been lost to care, and infants at risk for HIV infection. We report data from repeat testing for women in maternal and child health (MCH) services at 10 health facilities in Mozambique.MethodsRoutinely collected data from health facility registers are reported from April-November 2019. From antenatal care (ANC), we report numbers and proportions of women eligible for retesting; returned for care when retesting eligible; retested; and HIV-positive (HIV+) at retesting. From child welfare clinics (CWC), we report mothers retested; tested HIV-positive; HIV+ mothers linked to ART services; HIV-exposed infants (HEI) tested for HIV with polymerase chain reaction (PCR) tests; HEI testing PCR positive; PCR-positive infants linked to care.ResultsIn ANC, 28,233 pregnant women tested HIV-negative at first ANC visit, 40.7% had a follow-up visit when retesting eligible, among whom 84.8% were retested and 0.3%(N = 26) tested HIV+. In CWC, 26,503 women were tested; 0.8%(N = 212) tested HIV+ and 74.1%(N = 157) of HIV+ women were linked to care. Among 157 HEI identified in CWC, 68.4%(N = 145) received PCR testing and 19.3%(N = 28) tested positive.ConclusionIn ANC, less than half of pregnant women eligible for retesting returned for follow-up visits, and test positivity was low among women retested in ANC and CWC. In CWC, linkage to infant testing was poor and almost 20% of HEI were PCR-positive. Implementing retesting for pregnant and breastfeeding women is challenging due to high numbers of women and low testing yield.
Evolución de la representación del dentista en el cine
Authors: Vidal Cyril 
Published: March 2023

A lo largo de los años y con la evolución del cine, las representaciones de los dentistas también han evolucionado. Desde el cine mudo hasta el sonoro, desde el blanco y negro hasta el color, desde Hollywood hasta el cine europeo, hemos tratado de identificar las características del dentista en las películas. De ser un personaje secundario y anecdótico, ha pasado a ser el protagonista por excelencia.
De ser una caricatura y un argumento guionizado, el dentista se ha ido convirtiendo en un protagonista complejo. Estos cambios influyen en la percepción que el público tiene de la profesión dental, lo que permite esperar una mejor relación entre pacientes y dentistas, con el objetivo de mejorar la salud pública bucodental.
Approaches to organization of Fracture Liaison Services at the regional level with the involvement of primary care physicians
Authors: Evstigneeva L. P. , Kondakova V. G. , Dubowskoj A. V. , Avramenkova K. G. 
Published: March 2023

To prevent fractures which the elderly and the very old might deal with is a strategic task for preserving the life quality of the elderly and their independence from outside help, as well as reduce the health care and social support economic costs. The most effective and cost-effective organizational structure for reducing fractures frequency is the Fracture Liaison Service (FLS). The foundation of FLS at the regional level includes various models of these services, which is associated with a multi-level system of trauma care, different numbers of attached population and different number of specialists. Firstly, these are identification, assessment of clinical risk factors for osteoporosis, investigation for secondary osteoporosis causes and treatment initiation in the FLS with follow-up in the primary health care in 12–18 months’ time. Secondly, these are identification, risks assessment, patients’ investigation in the FLS during 3 months with the follow-up treatment initiating by the primary health care physician. And thirdly, these are assessment, investigation and treatment initiation by a primary care doctor immediately after trauma care. In any case of the FLS organization, a patient who has had a fragility fracture in any period after the fracture will be under the supervision of a primary care physician, and therefore additional efforts should be made by healthcare organizers, heads of a medical organization and other specialists in order to increase the identification of the patients with osteoporosis, their examination and treatment with anti-osteoporotic drugs in the primary health care. The article presents the results of the studies confirming the effectiveness of FLS with a coordinator, educational activities for patients and doctors, the role of a traumatologist in motivating a patient for examination and treatment, and other options to help a primary care physician with identifying, diagnosing and treating patients after fragility fractures.
Synthesis and characterization of a new complex based on antibiotic: Zirconium complex
Authors: Benmebarek Sabrina , Boussaa Sabiha Anas , Benmebarek Imad Eddine , Boudraa M’hamed , Merazig Hocine 
Published: March 2023

Abstract
It is well known that sulfonamide derivatives, through exchange of different functional groups without modification of the –S(O)2N(H)– function, can exhibit a wide variety of pharmacological activities. In addition, some metal complexes of these ligands have been prepared to promote rapid healing of burns in humans and animals, for example, the complex of Zn(ii) sulfadiazine. Their effectiveness does not depend solely on the slow release of the metal ion, but rather strongly on the nature of the material to which the metal is bound. Given the ability of sulfonamide derivatives to coordinate with metal atoms in different ways, considerable interest in the synthesis and structural aspects of new complexes has arisen. These results confirm that the significant chemical capacity of sulfonamides to act as ligands is based on the acidity of its –S(O)2N(H)– function, which gives a donor anionic ligand, allied to the presence of atoms vicinal to nitrogen, sulfur or oxygen of the heterocyclic ring, which provide the stereochemical requirements for the realization of complexes with monodentate ligand, chelating agent or bridging ligand, providing monomeric structures, dimeric arrangements and polymers. In addition, the aromatic amino group is responsible for the chemical versatility of the sulfonamides, since it can act as a coordination site, as well as a reactive site for chemical modifications of sulfonamide complexes with very interesting biological purposes. In the present work, the synthesis and structure of a novel sulfanilamide complex: nitro (4-aminobenzenesulfonamide) zirconium was presented. Characterization of the complex was performed by infrared spectroscopic, thermogravimetric and X-ray diffraction analysis.
Unions and Automation Risk: Who Bears the Cost of Automation?
Authors: Lee Changkeun , Kim Olivia Hye 
Published: March 2023

Abstract
Automation creates winners and losers. By examining establishment-level panel data, we explore how labour unions affect labor adjustment associated with automation. Although automation can increase new hires of junior and unskilled production workers, the presence of labour unions neutralizes these effects. The results suggest that labour unions have incentives to protect incumbent workers negatively affected by automation.
Entrepreneurship in Times of Crisis: A Comprehensive Review with Future Directions
Authors: Lee Yoowoo , Kim Jayoung , Mah Sunghyuck , Karr Angela 
Published: March 2023

Abstract
Despite an increased interest in crises within the field of entrepreneurship, there is still a lack of understanding about the interplay between different types of crises and entrepreneurship. In addition, the specific circumstances surrounding each type of crisis may also cause the conclusions of these studies to diverge or converge. To enhance our theoretical understanding of entrepreneurship during times of crisis, our review seeks to answer the following research questions: (1) How are the different types of crises addressed in entrepreneurship literature, and what similarities and differences exist? (2) How can we broaden our understanding and deepen our insights into the relationship between a crisis and entrepreneurship? In an effort to review the largest possible variety of crises that extends beyond political crises, natural disasters, and financial crises, we have also included a number of recent studies that examined COVID-19 from an entrepreneurial perspective. Following this, our study identifies six types of crises along with corresponding research themes, key findings, and critical shortcomings. This review also identifies multiple research gaps and suggests several future research directions, as well as theoretical approaches that researchers can take to build upon existing discussions surrounding entrepreneurship in times of crisis.