bluuebunny/crossref_metadata_2025_split huggingface dataset:
NNV024, a novel humanized anti-CD37 antibody with enhanced ADCC and prolonged plasma half-life in human FcRn transgenic mice for treatment of NHL
Authors: Generalov Roman , Fiorito Elisa , Foss Stian , Pascal Veronique , Heyerdahl Helen , Repetto-Llamazares Ada H. V. , Andersen Jan Terje , Tjønnfjord Geir E. , Skånland Sigrid S. , Dahle Jostein 
Published: July 2023

AbstractThere is an unmet medical need for new therapeutic approaches and targets for patients with non- Hodgkin lymphoma (NHL) who relapse or are refractory to anti-CD20 immunotherapy. Therefore, we developed a humanized IgG1antibody targeting CD37, which was tailored to be afucosylated for enhanced antibody-dependent cellular cytotoxicity (ADCC) (NNV024). In line with this, NNV024 induced three-fold more potent ADCC activity against patient-derived chronic lymphocytic leukemia (CLL) cells compared with anti-CD20 obinutuzumab. Moreover, NNV024 showed 2-fold higher ADCC activity than anti-CD20 rituximab and a recombinant version of DuoHexaBody-CD37 against both NHL and CLL cells. Survival was significantly longer after NNV024 treatment than with obinutuzumab in a mouse model. In addition, NNV024 showed a favourable plasma half-life in human FcRn transgenic mice of about 9-days, which was 2-fold longer than that of obinutuzumab and DuoHexaBody-CD37. These results warrant the further development of NNV024 as a treatment for NHL.
Cryo-electron tomography of enterovirus cell entry and endosome escape
Authors: Ishemgulova Aygul , Mukhamedova Liya , Trebichalská Zuzana , Rájecká Veronika , Payne Pavel , Šmerdová Lenka , Moravcová Jana , Hrebík Dominik , Buchta David , Škubník Karel , Füzik Tibor , Vaňáčová Štěpánka , Nováček Jiří , Plevka Pavel 
Published: July 2023

AbstractEnveloped viruses deliver their genomes into the cell cytoplasm by membrane fusion; in contrast, membrane penetration by non-enveloped viruses is more diverse and less well understood. Enteroviruses, one of the largest groups of non-enveloped viruses, cause diseases ranging from the common cold to life-threatening encephalitis. To initiate infection, most enteroviruses enter cells by endocytosis. However, how enterovirus particles or RNA genomes cross the endosome membrane into the cytoplasm remains unknown. Here we used cryo-electron tomography of infected cells to show that endosomes containing rhinovirus 2, echovirus 18, echovirus 30, or enterovirus 71 deform, rupture, and release their content into the cytoplasm. Blocking endosome acidification with bafilomycin A1 reduced the number of enterovirus particles that released their genomes in endosomes, but did not prevent them from reaching the cytoplasm. Inhibiting N-WASP-mediated post-endocytic membrane remodeling with wiskostatin promoted abortive enterovirus genome release in endosomes. We show that the rupture of endosomes also occurs in uninfected cells. In summary, our results indicate that cellular membrane remodeling disrupts enterovirus-containing endosomes and thus releases the virus genomes and particles into the cytoplasm. Since the studied enteroviruses employ different receptors for cell entry but are all delivered into the cytoplasm by cell-mediated endosome disruption, it is possible that many other enteroviruses utilize endosome rupture to infect cells.
Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP
Authors: Zhang Haotian , Kafeiti Nicholas , Lee Sandy , Masarik Kyla , Zheng Haoyi , Zhan Huichun 
Published: July 2023

ABSTRACTPatients with JAK2V617F-positive myeloproliferative neoplasms (MPNs) and clonal hematopoiesis of indeterminate potential (CHIP) are at a significantly higher risk of cardiovascular diseases (CVDs). Endothelial cells (ECs) carrying the JAK2V617F mutation can be detected in many MPN patients. Here, we investigated the impact of endothelial JAK2V617F mutation on CVD development using both transgenic murine models and human induced pluripotent stem cell lines. Our findings revealed that JAK2V617F mutant ECs promote CVDs by impairing endothelial function and undergoing endothelial-to-mesenchymal transition (EndMT). Importantly, we found that inhibiting the endothelial thrombopoietin receptor MPL suppressed JAK2V617F-induced EndMT and prevented cardiovascular dysfunction caused by mutant ECs. These findings propose that targeting the endothelial MPL receptor could be a promising therapeutic approach to manage CVD complications in patients with JAK2V617F-positive MPNs and CHIP. Further investigations into the impact of other CHIP-associated mutations on endothelial dysfunction are needed to improve risk stratification for individuals with CHIP.
FoxP3 recognizes microsatellites and bridges DNA through multimerization
Authors: Zhang Wenxiang , Leng Fangwei , Wang Xi , Ramirez Ricardo N. , Park Jinseok , Benoist Christophe , Hur Sun 
Published: July 2023

AbstractFoxP3 is a transcription factor (TF) essential for development of regulatory T cells (Tregs), a branch of T cells that suppress excessive inflammation and autoimmunity1-5. Molecular mechanisms of FoxP3, however, remain elusive. We here show that FoxP3 utilizes the Forkhead domain––a DNA binding domain (DBD) that is commonly thought to function as a monomer or dimer––to form a higher-order multimer upon binding to TnG repeat microsatellites. A cryo-electron microscopy structure of FoxP3 in complex with T3G repeats reveals a ladder-like architecture, where two double-stranded DNA molecules form the two “side rails” bridged by five pairs of FoxP3 molecules, with each pair forming a “rung”. Each FoxP3 subunit occupies TGTTTGT within the repeats in the manner indistinguishable from that of FoxP3 bound to the Forkhead consensus motif (FKHM; TGTTTAC). Mutations in the “intra-rung” interface impair TnG repeat recognition, DNA bridging and cellular functions of FoxP3, all without affecting FKHM binding. FoxP3 can tolerate variable “inter-rung” spacings, explaining its broad specificity for TnG repeat-like sequencesin vivoandin vitro. Both FoxP3 orthologs and paralogs show similar TnG repeat recognition and DNA bridging. These findings thus reveal a new mode of DNA recognition that involves TF homo-multimerization and DNA bridging, and further implicates microsatellites in transcriptional regulation and diseases.
The significance of general skills training for early career graduates: relationships with perceived organizational support, job satisfaction and turnover intention
Authors: Pinnington Ashly , Mir Farzana Asad , Ai Zehua 
Published: July 2023

Purpose
The purpose of this study is to address the mixed predictions about the relationship between general skills training and turnover intention of early career graduates by examining the mediating mechanisms of perceived organizational support (POS) and job satisfaction (JS) through which this relationship might be enacted. This study adopts organizational support theory as the guiding theory and examines the concept of POS as critical for predicting and explaining relationships in the conceptual framework.

Design/methodology/approach
A quantitative survey method was used on a sample of 147 Chinese early career graduate trainees. Analysis was conducted using partial least square-based structural equation modelling (PLS-SEM).

Findings
The main finding is that participation in general skills training (PGST) does not directly impact turnover intention, rather POS is a mechanism through which this negative relationship operates. This study also found significant evidence for serial mediation by POS on PGST and its relationship with turnover intention. Importantly, JS only has an effect on turnover intention when in the presence of serial mediation by POS.

Research limitations/implications
Cross-sectional study of a small survey sample. Nonetheless, the findings have major implications for research theories on the relationship of general skills training with employee turnover.

Social implications
PGST does not directly impact turnover intention, rather POS is a mechanism through which this negative relationship operates.

Originality/value
This research emphasizes the important role of POS in the relationship between early career graduate trainees’ PGST and their turnover intentions.
Evaluation of climate change effects on residential building cooling and heating demands in New Zealand: implications for energy efficiency standards and building codes
Authors: Jalali Zahra , Shamseldin Asaad Y. , Mannakkara Sandeeka 
Published: July 2023

PurposeClimate change reports from New Zealand claim that climate change will impact some cities such as Auckland from a heating-dominated to a cooling-dominated climate. The benefits and risks of climate change on buildings' thermal performance are still unknown. This paper examines the impacts of climate change on the energy performance of residential buildings in New Zealand and provides insight into changes in trends in energy consumption by quantifying the impacts of climate change.Design/methodology/approachThe present paper used a downscaling method to generate weather data for three locations in New Zealand: Auckland, Wellington and Christchurch. The weather data sets were applied to the energy simulation of a residential case study as a reference building using a validated building energy analysis tool (EnergyPlus).FindingsThe result indicated that in Wellington and Christchurch, heating would be the major thermal load of residential buildings, while in Auckland, the main thermal load will change from heating to cooling in future years. The revised R-values for the building code will affect the pattern of dominant heating and cooling demands in buildings in Auckland in the future, while in Wellington and Christchurch, the heating load will be higher than the cooling load.Originality/valueThe findings of this study gave a broader insight into the risks and opportunities of climate change for the thermal performance of buildings. The results established the significance of considering climate change in energy performance analysis to inform the appropriate building codes for the design of residential buildings to avoid future costly changes to buildings.
Educational achievements and export earnings: a comparison between leader and follower countries
Authors: Alam Gazi Mahabubul , Forhad Md. Abdur Rahman 
Published: July 2023

PurposeThis study examines whether education in developing countries directly impacts their foreign income from the top export sector.Design/methodology/approachAs most developing countries follow developed nations to shape their development, this study assumes developing countries as education-follower and developed countries as education-leader countries. Considering selected countries from the South Asian Regional Cooperation (SAARC) and African countries as follower countries and Group of Seven (G7) as leader countries, this study employs Dumitrescu-Hurlin Granger non-causality tests.FindingsThis study finds that education-follower countries' achievements do not directly impact foreign earnings from their leading export sectors. However, findings also confirm that leader countries have a bidirectional causal relationship between tertiary education and earnings from high technology exports.Originality/valueTo the best of the authors' knowledge, this is the first study urging research-intensive education with comparative advantages in international trade. Using educational attainment on export earnings from the leading sector, findings support dependency theory in education is still existed.
Addressing sustainability challenges as part of director’s duty in Malaysia
Authors: Mustafa Khan Nurul Jannah , Mohd Ali Hasani , Md Noor Alam Hazlina Shaik 
Published: July 2023

Purpose
The development of successful Sustainable Development Goals realization cannot be divorced from regulations governing sustainability information. Therefore, limited research on the regulatory environment regarding sustainability reporting in the Malaysian context requires further examination to ascertain the current framework. This study aims to critically assess the Malaysian Companies Act 2016 and Malaysian Code on Corporate Governance (MCCG) to examine the regulatory environment regarding the sustainability reporting framework. The examination is done to determine the extent of support provided under the Malaysian regulatory environment for the said practice.

Design/methodology/approach
A doctrinal methodology that relies on the extant literature, statutory instruments and case laws complemented by content analysis is adopted to explore the current regulatory environment regarding sustainability reporting.

Findings
The findings indicate that the Companies Act 2016 has already paved the way for the integration of corporate sustainability through the Business Review Report (BRR). However, the application is voluntary and hence could lead to inconsistent implementation. The MCCG has introduced the integrated reporting practice, but the application is limited to large companies on “apply and report” approach. This practice is voluntary to other types of companies, which diminishes the importance of sustainability reporting and gives rise to doubt about its efficiency in addressing sustainability in the long term. The current framework for sustainability reporting cannot be considered satisfactory, given the significance of sustainable development to the Malaysian economy and society, due to a lack of appropriate legal obligations.

Originality/value
This study is presently amongst the available legal literature on sustainability reporting practice in Malaysia, adding to its originality. This paper hopes to stimulate discussion among academicians on incorporating sustainability principles in the Companies Act 2016 and expanding directors’ duties.
Performance relative to aspiration and SMEs' internationalization speed: the moderating effects of policy knowledge and institutional distance
Authors: Zhang Ying , Cheng Cong 
Published: July 2023

PurposeThis study seeks to explore the relationship between performance relative to aspiration and SMEs' internationalization speed, and moderating effects of top management's policy knowledge and institutional distance between the above relation.Design/methodology/approachThis study tests the authors’ hypotheses using data on Chinese manufacturing SMEs over a 5-year period from 2013 to 2017. The authors leverage archival panel data on publicly listed companies on the SME Board, GEM and New OTC Market in the Shanghai and Shenzhen Stock Exchanges. The authors then collected data from the WIND and ZEPHYR databases.FindingsThe results confirm a U-shaped relation between performance relative to aspiration and SMEs' internationalization speed, and show that this relation is steepening by top management's policy knowledge in home country but flattening by institutional distance as environmental dynamics.Originality/valueThe study findings contribute to the international business field by exploring how a firm's risk situation in internationalization can change, thereby influencing SMEs' international expansion.
How India defines organizational citizenship behaviour: an inductive study from an employee perspective
Authors: Deshmukh Adwaita , Natu Sadhana 
Published: July 2023

PurposeOrganizational citizenship behaviour (OCB) holds importance for employees and employers. Although it is culturally relativistic, its definition is West-dominated. Conceptual investigations in non-Western cultures yield different dimensions of OCB. Existing OCB models lack contemporariness and reciprocity. Their perspective may be biased towards management. Practice based on such theory gives poor outcomes. To address these gaps, the authors reconceptualized OCB in the Indian context from an employee perspective.Design/methodology/approachThe authors conducted a qualitative study to build an employee-centric, inductive OCB model. The authors briefed respondents about the meaning of OCB and sought descriptions of instances of OCB performed or witnessed by them. The authors collected 478 descriptions from 49 private sector employees in India. The thematic analysis developed ten themes, each an OCB component, organized into four super-themes, denoting interpersonal, individual, organizational and community orientations.FindingsFive OCB components are new emic additions by the model: Building social relationships, emotionally mature behaviour, learning and knowledge creation, housekeeping and event management, and higher order citizenship. Organizational governance participation is absent from the model. Housekeeping and relationship building are the most appearing OCBs, while voice is the least. Findings are discussed in relation to temporal and cultural background, respondent characteristics and perspective.Practical implicationsOrganizations can better support employee OCBs by acknowledging OCBs unique to India, investigating low proportions of voice and civic virtue in the Indian model and informing people policies with this new knowledge.Originality/valueThis is the first attempt to build an inductive model of OCB in India from the employee perspective, making significant contributions to organizational theory and practice.
The strategic fit between strategic purchasing and purchasing involvement: the moderating role of leadership styles
Authors: Salhieh Loay , Mehiar Ala'a , Abushaikha Ismail , Reefke Hendrik , Bani-Ismail Loay 
Published: July 2023

PurposeThe aim of this study is to investigate and examine the impact of strategic purchasing practices (SPP) on strategic-fit (SF) by analyzing the influence of SPP on purchasing involvement in business strategy formulation with path-goal theory leadership styles as moderators.Design/methodology/approachUsing survey data from 320 respondents representing 64 manufacturing firms in the Middle East, the authors measure SPP, purchasing involvement, leadership styles and SF of the purchasing function with business strategy.FindingsBuilding on the path-goal approach to leadership, results suggest that participative, supportive and achievement-oriented leadership (AOL) styles are pure moderators, while directive leadership style (DLS) is a quasi-moderator in boosting the relationship between SPP and strategic purchasing involvement (SPI).Research limitations/implicationsLimitations of the sampling methodology and sample size restricts the scope for generalizing the hypotheses. Further, data were collected only from manufacturing companies. The paper provides managerial implications on purchasing involvement in business strategy formulation and the different roles of leadership styles.Originality/valueThis is the first scholarly work to examine the different leadership styles as a moderator that affects the strategic involvement and status of strategic purchasing.
Are scholar-type CEOs more conducive to promoting industrial AI transformation of manufacturing companies?
Authors: Xu Peng , Zhang Zichao 
Published: July 2023

PurposeIn order to effectively promote the deep integration of artificial intelligence and the real economy and empower real enterprises to improve quality and efficiency, this study regards the CEO as a high-end innovation resource and aims to empirically test the impact of scholar-type CEOs on the industrial artificial intelligence (AI) transformation of manufacturing enterprises.Design/methodology/approachGrounded on the upper echelons theory, this paper preliminarily selects A-share manufacturing listed companies in Shanghai Stock Exchange and Shenzhen Stock Exchange that are affiliated to enterprise groups from 2014 to 2020 as samples. Furthermore, the Logit regression is conducted to analyze the influence of scholar-type CEOs about industrial AI transformation.FindingsThe results show that scholar-type CEO plays a significant role in promoting industrial AI transformation. The parent-subsidiary corporations executives' ties positively moderates the impact of scholar-type CEOs on industrial AI transformation. Further, internal control quality plays a partial mediating role between scholar-type CEOs and industrial AI transformation. Compared with private enterprises, scholar-type CEOs play a stronger role in promoting industrial AI transformation of state-owned enterprises.Originality/valueFirst, this paper expands the research related to the influencing factors of industrial AI transformation based on upper echelons theory and clarifies the influencing mechanism of scholar-type CEOs affecting industrial AI transformation from the perspective of executives' behavior. Second, this study further enriches the research framework on the economic consequences of scholar-type CEOs and provides a useful supplement to the research literature in the field of upper echelons theory. Third, this paper is not limited to a single enterprise but involves the management practice of resource allocation within the enterprise groups, further clarifies the internal logic of the decision-making of industrial AI transformation of listed companies within the framework of enterprise groups, providing theoretical reference for the scientific design of the governance mechanism of parent-subsidiary companies.
Application of blockchain technology in the agri-food system: a systematic bibliometric visualization analysis and policy imperatives
Authors: Mohapatra Soumya , Sainath Banda , K.C. Anirudh , Lal Hminghlui , K. Nithin Raj , Bhandari Gunjan , Nyika Joan , R. Sendhil 
Published: July 2023

Purpose Blockchain technology (BCT), since its emergence touted to be disruptive, is gaining momentum, especially in the agri-food system owing to its multiple benefits.Design/methodology/approach The authors attempted to conduct a systematic bibliometric visualization analysis of the BCT in the agri-food system. The analysis investigated the list of countries and institutions that conducted research on BCT in agriculture, growth trend analysis in research publications, bibliographic coupling of journals using the VOSviewer tool, and the countries and institutions researching BCT.Findings The authors discovered that China, the USA and India were the highly active countries in BCT research and publication. However, India has only limited research collaboration with other countries as compared to China and the USA. The keyword analysis indicates the role of BCT in order to maintain the transparency of the supply chain by means of protecting the privacy of the personal data of the stakeholders.Research limitations/implicationsMore research related to the implementation of BCT in livestock, fishery and agro-forestry sector is recommended.Social implications The case examined is of particular interest as it is concerned with efficient supply chain management.Originality/value This study adds value and evidence to the scope and benefits of BCT by providing a comprehensive literature review, with a special focus on the opportunities and challenges concerned with implementation of BCT in the Indian agri-food system.HighlightsBlockchain technology (BCT) – a promising tool to resolve issues in agriculture supply chain.BCT ensures transparency and protection of information along the supply chain transactions.China, the USA and India are the highly active countries in BCT research and publication.Multiple potential benefits to stakeholders are attributed to the BCT in the agri-food system.The key challenge is to bridge the digital gap between developed and developing nations.Future research on BCT should aim at easing and undistorted competition among stakeholders.