bluuebunny/crossref_metadata_2025_split huggingface dataset:
FP-4: SPIRIT OF KYOTO, SPIRIT OF ZEN
Authors: Matsuyama Daiko 
Published: January 2023

Welcome to Kyoto. Kyoto is the ancient capital of Japan, a university town, a gastronomic city, and one of the most religious cities in the world. Kyoto has developed a unique culture over its nearly 1,300-year history, and the influence of religion is particularly evident.
In particular, Kyoto is home to seven head quarters of Zen, and it is no exaggeration to say that it is the center of Zen in Japan. Zen has been supported by the ruling class since ancient times and has had a profound influence on Kyoto's culture, including its gardens, architecture, festivals, customs, and cuisine.
What is special about Kyoto culture? What is fascinating about it? I will talk about Kyoto's spirituality from a religious perspective to enrich your stay in Kyoto.
CV:Born in 1978 in Kyoto, Mr. Matsuyama obtained his Master's degree in Agriculture and Life Sciences from the University of Tokyo. After three and half years of training at Heirin-ji Temple, Niiza, he became the deputy priest of Taizoin Temple in 2007. Matsuyama is acclaimed for organizing intercultural activities such as Zen experience tours for foreign visitors and talks at embassies in Japan and at the Foreign Correspondents’ Club. In May 2009, he was elected as a Japan Tourism Agency's Ambassador for its “Visit Japan” Campaign. He has been a member of Kyoto's Ambassadors for Tourism since 2011, and was listed as one of “The Top 100 People of the New Generation 2016” in Nikkei Business. And he was appointed as a fellow of US-Japan Leadership Program from 2016. In 2018, he was invited to Israel as the delegate of Young Leaders Program. And he also became a visiting lecturer at Stanford Univ. He received The Award of Commissioner for Cultural Affairs and Shigemitsu Award from Japan society in Boston in 2019. He is serving as an appointed member of the Kyoto City Board of Education and an Outside Director of V-cube, a tech startup, since 2021.
As a young representative of the Zen Sect in Japan, Matsuyama has interacted with many religious leaders, such as having an audience with the Roman Catholic Pope and conversing with the 14th Dalai Lama. He also participated in the Davos World Economic Forum in 2014, and continues to work actively beyond national and religious borders. He is the author of the book, Forget What's Important First: 30 Zen Teachings for the Wavering Soul (Sekai Bunka Publishing, 2014) Strolling around Zen Gardens in Kyoto (PHP Publishing, 2016) Introduction of ZEN for workers (Kodansya Publishing, 2016).
ME-1: ROLE OF MINERALOCORTICOID RECEPTOR BLOCKERS IN RESISTANT AND REFRACTORY HYPERTENSION
Authors: Oparil Suzanne 
Published: January 2023

Resistant hypertension is defined as blood pressure (BP) that remains above goal in spite of compliance with full doses of 3 or more antihypertensive medications of different classes. Ideally, a thiazide-like diuretic should be included in this 3 drug regimen. Classically, the recommendation has been to add a mineralocorticoid receptor antagonist such as spironolactone or eplerenone to the regimen of these resistant hypertensive patients to gain BP control. The study that deserves major credit for establishing this practice is the Prevention And Treatment of Hypertension With Algorithm based therapY (PATHWAY) study (Williams B, et al. Lancet. 386:2059–2068, 2015). PATHWAY compared the mineralocorticoid receptor antagonist spironolactone to doxazosin and bisoprolol in patients with resistant hypertension and demonstrated that spironolactone was overwhelmingly more successful in controlling the patient's BP and was also very well tolerated. The results of PATHWAY established aldosterone antagonists as the best add-on therapy for patients with resistant hypertension. However, spironolactone and other steroidal mineralocorticoid receptor antagonists such as eplerenone do have major adverse effects which can limit their use. These include sex hormone-related adverse effects such as gynecomastia and breast tenderness in women and erectile dysfunction and feminization in men. A solution to this problem, which is currently under active development, is use of non-steroidal mineralocorticoid receptor antagonists such as esaxerenone and finerenone (Figure 1). These non-steroidal mineralocorticoid receptor antagonists are bulky molecules which bind to the mineralocorticoid receptors and effectively prevent their activation. Specifically, esaxerenone has been shown to be as effective as eplerenone in lowering BP and to be well tolerated in Japanese patients with essential hypertension. Esaxerenone also has no sex hormone-dependent adverse effects. The question now is whether the non-steroidal mineralocorticoid receptor antagonists are to be the answer for resistant and refractory hypertension.
Figure 1. Molecular Structures of Steroids and MR Blockers
Adapted from: Tezuka Y, Ito S. The time to reconsider mineralocorticoid receptor blocking strategy: Arrival of nonsteroidal mineralocorticoid receptor blockers. Curr Hypertens Rep. 2022 Jul;24(7):215–224. doi: 10.1007/s11906-022-01177-6.
SP-3: PRECISION MEDICINE
Authors: Dominiczak Anna Felicja 
Published: January 2023

Precision Medicine is one of the most impactful global opportunities in healthcare. We can debate the name, whether it is precision, stratified or personal but at the highest strategic level, we all share a common goal to enable a world where healthcare is informed by each person unique clinical, molecular and lifestyle information.
Precision Medicine will spur a revolution in healthcare, bringing the prospects of earlier, pre-symptomatic diagnosis, more effective treatment, significant cost savings for the NHS and all the above combined with better patient outcomes.
Moreover, Precision Medicine will reach the global market value of £134 billion by 2025 thus contributing to unprecedented developments in Life Sciences industry, including new jobs creation, and a significant economic growth. The UK is in a prime position to lead on Precision Medicine globally due to the NHS facilitating advanced health data management, excellent genomics and other omics, new imaging modalities and major advances in the artificial intelligence applied to diagnostics. All the above is supported by the triple helix approach, which involves close collaborations among academic researchers, the NHS and industry.
The Covid-19 pandemic has made a major contribution to the UK molecular diagnostic capability. This legacy includes very high throughput laboratories, which should become key building blocks for the UK cutting edge Precision Medicine strategy for the next decade and beyond.
S-01-3: SMART WELLNESS HOUSING AND BLOOD PRESSURE CONTROL
Authors: Umishio Wataru , Ikaga Toshiharu , Kario Kazuomi 
Published: January 2023

Objective:
Mortality due to cardiovascular diseases (CVDs) rises sharply in winter, a phenomenon known as excess winter mortality. It is partially explained by cold exposure induced hypertension. Nevertheless, existing countermeasures for the prevention of hypertension and CVDs place emphasis only on improving lifestyle habits. Improving life environment has attracted attention recently because people spend 60–70% of their time at home. Therefore, we aimed to quantitatively evaluate the relationship between housing thermal environment and blood pressure (BP) in a real-world setting.

Design and method:
We conducted a nationwide prospective intervention study named the Smart Wellness Housing survey in Japan, as a nonrandomized controlled trial. The intervention was the thermal insulation retrofitting of homes. Participants were recruited by construction companies throughout all 47 prefectures of Japan. Home BP and indoor temperature were measured for 2 weeks before and after the intervention in winter (November-March) of FY 2014 to 2019.

Results:
Cross-sectional analyses before intervention involving about 2900 participants (1840 households) showed that systolic blood pressure (SBP) in the morning had significantly higher sensitivity to changes in indoor temperature (8.2 mmHg increase/10°C decrease) than that in the evening (6.5 mmHg increase/10°C decrease) in participants aged 57 years (mean age in this survey). Interaction terms between age/women and indoor temperature were significant, indicating that SBP in older residents and women was vulnerable to indoor temperature change.
The association between BP variability and indoor temperature instability was also analyzed using the morning-evening (ME) difference as an index of diurnal variability and the standard deviation (SD) of 2-week data as an index of day-by-day variability. The analyses showed that the ME difference in indoor temperature was closely correlated with the ME difference in SBP (0.85 mmHg/°C). The SD of indoor temperature was also associated with the SD of SBP (0.61 mmHg/°C).
In the comparison of before and after intervention, insulation retrofitting significantly reduced morning SBP by 3.1 mmHg. In addition, there was heterogeneity in the effect of insulation retrofitting on morning SBP in hypertensive patients compared with normotensive occupants (-7.7 versus -2.2 mmHg).

Conclusions:
Hypertension might be not only lifestyle diseases but also life-environment diseases. Residents should keep the indoor temperature high to reduce BP level and keep it stable to reduce BP variability through strategies such as installing high thermal insulation. We expect that these results will be useful to prevent excess winter mortality due to CVDs.
S-02-1: ASSOCIATION OF HYPERTENSION AND DYSLIPIDEMIA WITH COGNITIVE FUNCTION IN COMMUNITY-DWELLING OLDER ADULTS: THE SONIC STUDY
Authors: Nakamura Yuko , Kabayama Mai , Godai Kayo , Akasaka Hiroshi , Gondo Yasuyuki , Masui Yukie , Arai Yasumichi , Ishizaki Tatsuro , Rakugi Hiromi , Kamide Kei 
Published: January 2023

Aim:
Hypertension, dyslipidemia, and those combinations are very common in older adults. However, the association between cognitive decline and the combination of hypertension and dyslipidemia in older adults is still controversial. Therefore, we investigate the association between cognitive decline and hypertension, dyslipidemia, and their combination in community-dwelling older people in their 70 s, 80 s, and 90 s in the long-term observational Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study.

Method:
We conducted the Montreal Cognitive Assessment Japanese version (MoCA-J) by trained psychologists and blood testing by medical staff in 1188 participants in their 70 s, 80 s, and 90 s who participated in the SONIC study. Multiple regression analysis was performed in each age cohort to assess these associations at 3-year follow-up after adjusting for covariate factors; sex, BMI, smoking history, Moca-J score at baseline, anti-dyslipidemia medications, anti-hypertensive medications, and diabetes mellitus. After that, we selected individuals with hypertension and then performed the analysis of the association between lipid levels and cognitive function.

Results:
At baseline, the percentages of hypertension were 64%(n = 368) in the age 70 s group, 81%(n = 446) in the age 80 s group, and 82%(n = 51) in the age 90 s group, and the percentages of dyslipidemia were 62%(n = 354) in the age 70 s group, 62%(n = 340) in the age 80 s group, and 63%(n = 39) in the 90 s group. The percentages of the participants combined both were 42%(n = 243) in the age 70 s group, 52%(n = 286) in the age 80 s group, and 52%(n = 32) in the 90 s group. The mean MoCA-J score adjusted by the educational level at baseline was 23.94 ± 3.10 in the age 70 s group, 22.25 ± 3.53 in the age 80 s group, and 19.68 ± 3.71 in the 90 s group. By conducting multiple regression analysis, no significant relationship was found between hypertension, dyslipidemia, and their combination and Moca-J score in every age group. On the other hand, high low-density lipoprotein cholesterol (LDL) and high high-density lipoprotein cholesterol (HDL) level resulted in higher Moca-J scores at follow-up in the age 70 s group (LDL: β = 0.074; P = 0.042, HDL: β = 0.096; P = 0.010). Subsequently, only participants with hypertension were selected to compare the association between each lipid level and Moca-J scores, and high HDL resulted in higher Moca-J scores at follow-up (β = 0.059, P = 0.025).

Conclusion:
The results suggest that maintaining HDL level may be important in sustaining cognitive function in the community-dwelling older adults population with hypertension.
S-03-3: ASSOCIATION BETWEEN PEP/ET AND LEFT VENTRICULAR EJECTION FRACTION OF PULSE WAVE MEASUREMENTS IN PATIENTS AT HIGH CARDIOVASCULAR RISK
Authors: Ishiyama Yusuke , Kabutoya Tomoyuki , Hoshide Satoshi , Kario Kazuomi 
Published: January 2023

Background:
Increased pre-ejection period to ejection time (PEP/ET) obtained by pulse wave measurements is known to be associated with reduced cardiac function. However, PEP/ET and left ventricular function have not been studied in detail in patients at cardiovascular risk.

Methods:
Eight hundred and sixty-one patients enrolled in the Coupling study and underwent echocardiography were included. We measured brachial-ankle pulse wave velocity, and estimated the PEP/ET ratio. Left ventricular ejection fraction (LVEF) was measured by echocardiography and classified as normal (LVEF≥ 60%, N = 706), heart failure with preserved ejection fraction (HFpEF: LVEF 51–60%, N = 105), heart failure with mid-range ejection fraction (HFmrEF: LVEF 41–50%, N = 31), heart failure with reduced ejection fraction (HFrEF: LVEF< 40, N = 19), and the relationship between cardiac function and PEP/ET was examined.

Results:
PEP/ET and EF was significantly inversely associated with PEP/ET (R = -0.33, p < 0.001). PEP/ET increased progressively with normal, HFpEF, HFmrHF, and HFrEF (0.32 ± 0.07, 0.37 ± 0.09, 0.40 ± 0.13, 0.46 ± 0.16, ANOVA P < 0.001).The receiver operating characteristic curve predicting LVEF < 60% had a PEP/ET of 0.4 (area: 0.695); PEP/ET ≥ 0.4 was a significant predictor of EF < 60% (odds ratio 5.41, 95% confidence interval 3.54–8.26).

Conclusions:
Increased PEP/ET obtained by pulse wave measurements was associated with reduced contractility, and PEP/ET ≥ 0.4 was a significant predictor of reduced cardiac function.
S-04-4: INCONSISTENT GUIDELINES-BASED CONTROL STATUS OF OFFICE, HOME, AND AMBULATORY BLOOD PRESSURE MEASURED BY AN ALL-IN-ONE BP MONITORING DEVICE
Authors: Kario Kazuomi , Hoshide Satoshi , Tomitani Naoko , Nishizawa Masafumi , Yoshida Tetsuro , Kabutoya Tomoyuki , Fujiwara Takeshi , Mizuno Hiroyuki , Narita Keisuke , Komori Takahiro , Suzuki Daisuke , Nakazato Jun , Nakagawa Naoki , Katsuya Tomohiro , Harada Noriko 
Published: January 2023

Objective:
Inconsistencies between office and out-of-office blood pressure (BP) values (described as white-coat hypertension or masked hypertension) may be attributable in part to differences in the BP monitoring devices used. We studied the inconsistency of the classification of BP control (well-controlled BP vs. uncontrolled BP) among office, home, and ambulatory BPs by using a validated all-in-one BP monitoring device.

Design and method:
In the nationwide, general practitioner-based multicenter HI-JAMP study, 2,322 hypertensive patients treated with antihypertensive drugs underwent office BP measurements and 24-h ambulatory BP monitoring (ABPM), consecutively followed by 5-day home BP monitoring (HBPM), using the same all-in-one device over a total of seven BP measurement days.

Results:
Using the thresholds of the JSH2019 and ESC2018 guidelines, the subjects with consistently well-controlled office (<140mmHg) and home systolic BP (SBP) (<135mmHg) (n = 970) also tended to have well-controlled 24-h SBP (<130mmHg) (n = 808, 83.3%). The subjects with consistently uncontrolled office and home SBP (n = 579) also tended to have uncontrolled 24-h SBP (n = 444, 80.9%). Among the subjects with inconsistent classifications of office and home BP control (n = 803), 46.1% had inconsistent ABPM-vs.-HBPM out-of-office BP control status. When the 2017 ACC/AHA thresholds or JSH2019 target BP thresholds were applied as an alternative, the results were essentially the same.

Conclusions:
The combined assessment of office and home BP is useful in clinical practice. Especially for patients whose office BP classification and home BP classification conflict, the complementary clinical use of both HBPM and ABPM might be recommended.
S-04-5: AUTOMATED DETECTION OF ATRIAL FIBRILLATION DURING ROUTINE OSCILLOMETRIC MEASUREMENT OF BLOOD PRESSURE: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kyriakoulis Konstantinos G , Kollias Anastasios , Chardouvelis Panagiotis , Ntousopoulos Vasileios , Menti Ariadni , Destounis Antonios , Stergiou George S 
Published: January 2023

Objective:
Efficient screening strategies are necessary for detecting atrial fibrillation (AF) aiming at stroke prevention. In 2013 the UK National Institute for Health and Care Excellence recommended opportunistic AF screening during routine office blood pressure (BP) measurement using an automated monitor with high diagnostic accuracy. This systematic review and meta-analysis evaluated the current evidence on the diagnostic accuracy of AF detection technologies implemented in automated devices for office, home, and ambulatory BP measurement.

Design and method:
A systematic PubMed search was conducted using the algorithm: “atrial fibrillation” AND (“blood pressure” OR “blood pressure monitor” OR “blood pressure device” OR “blood pressure measurement”) AND (detect∗ OR screen∗), until May 2022.

Results:
Initial search retrieved 423 articles of which 37 were relevant and 17 were included in meta-analysis. Three studies (n = 1465, weighted age 77.8 years, males 51%, AF prevalence 10.4%) evaluated the diagnostic accuracy of office BP monitors. Meta-analysis showed pooled sensitivity, specificity, and accuracy: 94% (95% CI 88–98%), 94% (89–98), and 94% (89–97), respectively. Eleven studies (n = 8343, weighted age 66.7 years, males 47%, AF prevalence 7%) evaluated the diagnostic accuracy of home BP monitors. Pooled sensitivity, specificity and accuracy were 98% (93–100%), 94% (90–97) and 95% (91–97), respectively. Three studies (n = 238, weighted age 68.0 years, males 62%, AF prevalence 12%) evaluated the diagnostic accuracy of ambulatory BP monitors. Pooled sensitivity, specificity and accuracy were 94% (81–100%), 82% (77–87) and 83% (78–88), respectively. Simultaneous (or shortly before/after BP measurement) 12- or single-lead electrocardiography (ECG) was used as reference method in studies evaluating office/home BP monitors. For ambulatory BP monitors, two studies used 24h-continuous ECG Holter monitoring and one study used pacemaker recordings (implanted for sick sinus syndrome). Analysis per individual was performed for the evaluation of office and home BP monitors (an individual was considered as AF positive if the majority of BP readings indicated AF, e.g., 2 of 3). For ambulatory BP monitors, analysis per reading was performed (vs. simultaneous ECG trace). With increasing AF prevalence across studies, meta-regression analysis showed higher positive predictive value and a trend towards lower negative predictive value.

Conclusions:
There is considerable evidence that AF detection during routine automated BP measurement in elderly people using office, home, or ambulatory BP monitors has high diagnostic accuracy. AF screening in the elderly during routine office and out-of-office BP measurement is feasible and can increase early detection of asymptomatic AF.
S-05-2: DISASTER HYPERTENSION AND CARDIOVASCULAR DISEASE
Authors: Hoshide Satoshi 
Published: January 2023

Previous papers have reported that cardiovascular events increase over the following months after earthquake. One of the reasons for the increase in events has been considered the activation of the sympathetic nervous system due to stress, dehydration and decreased activity. In addition, the increased intake of canned foods with high salt due to prolonged shelter living may lead to the development and exacerbation of hypertension, i.e., disaster hypertension. We reported that the estimated salt intake of the victims was related to their blood pressure (BP) levels, and aging, obesity, diabetes, and chronic kidney disease may be aggravating factors (Hoshide et al. Hypertension 2019; 74: 564–571).
After the Great East Japan Earthquake on March 11, 2011, we have been providing support to the affected areas. As a part of this effort, we introduced an information technology-based home BP monitoring approach (the web-based Disaster Cardiovascular Prevention: DCAP) for the purpose of BP control for victims in evacuation centers (Kario et al. Lancet 2011; 378: 1125–7). This system and was able to promptly identify danger signals of elevated BP and reflect them in treatment. This system is still in use today, the BP of the victims is well controlled (Nishizawa et al. J Clin Hypertens 2017; 19: 26–29).
S-06-6: HYPERTENSION MANAGEMENT IN ATRIAL FIBRILLATION PATIENTS IN MIDDLE EAST
Authors: Haji Ghazi Farhan 
Published: January 2023

Introduction:
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Epidemiologic studies have shown that the presence of AF increases risk of mortality by 1.5–1.9 times in the age-matched general population.
Hypertension (HTN) is one of the most common conditions in the general practice. It is an independent predictor for the development of AF. Given that uncontrolled HTN increases the risk of cardiovascular diseases, coronary artery disease (CAD), stroke, and chronic kidney disease (CKD), it may be hypothesized that the coexistence of HTN and AF may be associated with higher morbidity and mortality.
Objective: