bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIR-модель розповсюдження та врахування результатів негативного впливу інформаційних каналів на громадську думку населення
Authors: Войтко Олександр , Солонніков Владислав , Полякова Олена 
Published: February 2023

В статті розглядається задача кількісного оцінювання приросту нових активних фоловерів вітчизняного новинного каналу в соціальних мережах з урахуванням результатів негативної дії каналу однакової інформаційної спроможності, але проросійського соціально-політичного спрямування, та сумарного впливу їх повідомлень на громадську думку населення досліджуваного регіону країни щодо вступу України в Північноатлантичний альянс та Європейський Союз.
Для досягнення мети дослідження авторами в якості математичного інструментарію використовувалася аналітична модель процесу розповсюдження інформації (SIR-модель епідемії). Застосування цієї моделі було здійснено за допомогою інтерактивної системи Matlab R2007. Побудовані графіки процесу зростання кількості активних фоловерів зазначених інформаційних каналів як результат їхнього впливу на різні цільові аудиторії населення. Здійснена оцінка кінцевих сумарних змін кількості нових фоловерів інформаційних каналів взаємно протилежного соціально-політичного спрямування як результат їх впливу на різні цільові аудиторії за два календарні тижні. Обґрунтована можливість розрахунку необхідної кількості вітчизняних інформаційних каналів вибраної інформаційної спроможності для досягнення запланованого прогнозного розвитку громадської думки населення України щодо вступу до ЄС та НАТО при врахуванні негативного впливу діючих інформаційних каналів противника.
Pendampingan Legalitas Usaha Umkm untuk Meningkatkan Kredibilitas Masyarakat Desa Karanganom
Authors: Muhammad Anasrulloh  , Kadeni Kadeni , W Maria Agatha Sri , S Imam Sukwatus 
Published: February 2023

Kelembagaan hal yang perlu diperhatikan karena akan berpengaruh terhadap citra dan kredibilitas masyarakat, masyarakt akan lebih yakin ketika melakukan aktivitas ekonomi atau bertransaksi dengan pelaku UMKM yang mempunyai legalitas kelembagaan yang jelas. Pelaku UMKM di desa tersebut kurang begitu memperhatikan pentingnya legalitas NIB (Nomor Induk Berusaha), sehingga masih banyak pelaku UMKM di desa karanganom yang belum memahami pentingnya pendaftaran usahanya dan masih banyak pelaku BUMDes dikaranganom yang belum memahami pengelolaannya, oleh karena pelaku UMKM memerlukan pendampingan dalam pembuatan NIB dan pengelolaan BUMDes di desa karanganom. Agar dapat mengikuti harapan Pemerintah, salah satu solusi yang bisa dilakukan oleh akademisi dan mahasiswa akademis yaitu Pengabdian kepada Masyarakat dalam Program KKN mahasiswa dengan melakukan sosialisasi peningkatan literasi dan pendampingan mengenai legalitas usaha dan pengelolaan untuk pelaku UMKM dan BUMDes Desa Karanganom. Tahapan yang dilakukan dalam pengabdian ini dengan teknik Presentasi, demonstrasi dan praktik. Paparan materi disampaikan di Aula utama Kantor Desa Karanganom, sedangkan pendampingan dalam pembuatan NIB dari rumah ke rumah peserta melalui program terintegrasi dengan mahasiswa yang melaksanakan Kuliah Kerja Nyata (KKN) kelompok Desa Karanganom Tim A. Kegiatan ini diikuti oleh kurang lebih 65 orang dari unsur pelaku UMKM yang terdaftar di desa karanganom dan 24 orang mahasiswa/I dari Universitas Bhineka PGRI
Pelatihan Perencanaan dan Pengelolaan Keuangan Yang Efektif dan Efisien Pada UMKM di Kabupaten Sorong Papua Barat Daya
Authors: LESTARI BEKTI WIJI , Bintari Wisang Candra , Zain Evi Mufrihah , Lewenussa Ramli , Andjar Febry Jein , Rawi Rais Dera Pua 
Published: February 2023

Tujuan pengabdian ini adalah untuk meningkatkan pengetahuan dan keterampilan pengelolaan keuangan yang efektif dan efisien. Untuk mengubah pola piker pelaku UMKM bahwa perencanaan dan pengelolaan keuangan yang efektif dan efisien sangat penting dilakukan dalam UMKM. Metode pelaksanaan dalam pengabdian ini terbagi menjadi tiga tahapan, yaitu tahap awal, tahap inti dan tahap akhir. Pada tahap awal terdapat tiga bagian dalam kegiatan tahap awal ini, yaitu (1) observasi dan survei lapangan; (2) kelengkapan administrasi; dan (3) merancang kegiatan inti serta menyusun materi pelatihan. Dari informasi awal yang diperoleh bahwa UMKM yang ada di Kabupaten Sorong sudah membuat sebuah perencanaan dan pengelolaan keuangan, namun yang dilakukan belum maksimal dan belum sesuai dengan yang ditetapkan oleh OJK yaitu perencanaan dan pengelolaan keuangan yang efektif dan efisien. UMKM yang ada di kabupaten sorong belum mampu melakukan pencatatan keuangan secara efektif. Pengabdian Kepada masyarakat tentang Perencanaan dan Pengelolaan keuangan yang efektif dan efisien yakni pelaku UMKM mengupayakan agar ibu-ibu lebih memahami pentingnya pengelolaan keuangan pada keberlangsungan UMKM dan keuangan keluarga.
Keakurasian Metode Shooting untuk Menyelesaikan Masalah Kondisi Batas pada Persamaan Sturm-Liouville
Authors: Habibah Ummu , Mulyanti Nielda Alifah 
Published: February 2023

Pada penelitian ini dibahas keakurasian metode shooting/tembakan untuk menyelesaikan masalah kondisi batas Dirichlet pada persamaan Sturm-Liouville yang berbentuk persamaan diferensial orde dua, dengan kondisi batas Dirichlet. Persamaan Sturm-Liouville diselesaikan numerik menggunakan metode shooting. Simulasi numerik dilakukan dengan beberapa nilai (ukuran langkah). Keakurasian metode shooting diperoleh dengan cara dibandingkan solusi numeriknya terhadap solusi eksak, serta dibandingkan dengan solusi numerik menggunakan metode beda hingga. Hasil simulasi menunjukkan bahwa metode tembakan (shooting) menghasilkan solusi numerik yang lebih baik untuk mengaproksimasi masalah kondisi batas pada persamaan Sturm-Liouville dibandingkan metode beda hingga karena menghasilkan kesalahan numerik yang lebih kecil.
Influence of intra-abomasal administration of L-DOPA on circulating catecholamines and feed intake in cattle
Authors: Valente Eriton E. L. , Klotz James L. , Egert-McLean Amanda M. , Costa Gustavo W. , May John B. , Harmon David L. 
Published: February 2023

Dopamine has multiple physiological functions including feed intake control in which it can act as an anorectic or orexigenic agent. This study had the objective to evaluate intra-abomasal administration of L-DOPA (levodopa; L-3,4-dihydroxyphenylalanine) from -Mucuna prurienson circulating catecholamines, indicators of energy metabolism and feed intake in cattle. Eight Holstein steers (340 ± 20 kg) fitted with ruminal cannula were used in a replicated 4 x 4 Latin Square design experiment. Intra-abomasal infusion of L-DOPA at 0, 0.5, 1 and 2 mg/kg BW was carried out for seven days and blood samples were collected at 0, 30, 60, 120, 240 and 480 min from L-DOPA infusion on day 7. The area under the curve (AUC) of plasma L-DOPA and free dopamine increased quadratically with the administration of L-DOPA. However, the AUC of plasma total dopamine had a positive linear response with the increase of L-DOPA. Conversely, the serum 5-hydroxytriptophan (5-HTP), plasma serotonin, serum serotonin, serum tyrosine, plasma glucose and plasma free fatty acids were not affected by the intra-abomasal infusion of L-DOPA. The circulating concentration of the epinephrine, norepinephrine, serotonin, glucose and free fatty acids did not change with L-DOPA infusion. It can be concluded that intra-abomasal L-DOPA administration produced a strong increase in circulating dopamine with no change in energy metabolites and feed intake in cattle.
An analysis of lateralized neural crest marker expression across development in the Mexican tetra, Astyanax mexicanus
Authors: Gross Joshua B. , Berning Daniel , Phelps Ayana , Luc Heidi 
Published: February 2023

The biological basis of lateralized cranial aberrations can be rooted in early asymmetric patterning of developmental tissues. However, precisely how development impacts natural cranial asymmetries remains incompletely understood. Here, we examined embryonic patterning of the cranial neural crest at two phases of embryonic development in a natural animal system with two morphotypes: cave-dwelling and surface-dwelling fish. Surface fish are highly symmetric with respect to cranial form at adulthood, however adult cavefish harbor diverse cranial asymmetries. To examine if lateralized aberrations of the developing neural crest underpin these asymmetries, we used an automated technique to quantify the area and expression level of cranial neural crest markers on the left and right sides of the embryonic head. We examined the expression of marker genes encoding both structural proteins and transcription factors at two key stages of development: 36 hpf (∼mid-migration of the neural crest) and 72 hpf (∼early differentiation of neural crest derivatives). Interestingly, our results revealed asymmetric biases at both phases of development in both morphotypes, however consistent lateral biases were less common in surface fish as development progressed. Additionally, this work provides the information on neural crest development, based on whole-mount expression patterns of 19 genes, between stage-matched cave and surface morphs. Further, this study revealed ‘asymmetric’ noise as a likely normative component of early neural crest development in natural Astyanax fish. Mature cranial asymmetries in cave morphs may arise from persistence of asymmetric processes during development, or as a function of asymmetric processes occurring later in the life history.
Novel compound heterozygous variants in the USH2A gene associated with autosomal recessive retinitis pigmentosa without hearing loss
Authors: Huang Yanxia , Yuan Lamei , He Guiyun , Cao Yanna , Deng Xiong , Deng Hao 
Published: February 2023

Background: Retinitis pigmentosa (RP) is a group of progressive inherited retinal dystrophies characterized by the primary degeneration of rod photoreceptors and the subsequent loss of cone photoreceptors because of cell death. It is caused by different mechanisms, including inflammation, apoptosis, necroptosis, pyroptosis, and autophagy. Variants in the usherin gene (USH2A) have been reported in autosomal recessive RP with or without hearing loss. In the present study, we aimed to identify causative variants in a Han-Chinese pedigree with autosomal recessive RP.Methods: A six-member, three-generation Han-Chinese family with autosomal recessive RP was recruited. A full clinical examination, whole exome sequencing, and Sanger sequencing, as well as co-segregation analysis were performed.Results: Three heterozygous variants in the USH2A gene, c.3304C&gt;T (p.Q1102*), c.4745T&gt;C (p.L1582P), and c.14740G&gt;A (p.E4914K), were identified in the proband, which were inherited from parents and transmitted to the daughters. Bioinformatics analysis supported the pathogenicity of the c.3304C&gt;T (p.Q1102*) and c.4745T&gt;C (p.L1582P) variants.Conclusions: Novel compound heterozygous variants in the USH2A gene, c.3304C&gt;T (p.Q1102*) and c.4745T&gt;C (p.L1582P), were identified as the genetic causes of autosomal recessive RP. The findings may enhance the current knowledge of the pathogenesis of USH2A-associated phenotypes, expand the spectrum of the USH2A gene variants, and contribute to improved genetic counseling, prenatal diagnosis, and disease management.
A pilot study exploring the association of bronchial bacterial microbiota and recurrent wheezing in infants with atopy
Authors: Tang Wei , Zhang Lei , Ai Tao , Xia Wanmin , Xie Cheng , Fan Yinghong , Chen Sisi , Chen Zijin , Yao Jiawei , Peng Yi 
Published: February 2023

BackgroundDifferences in bronchial microbiota composition have been found to be associated with asthma; however, it is still unclear whether these findings can be applied to recurrent wheezing in infants especially with aeroallergen sensitization.ObjectivesTo determine the pathogenesis of atopic wheezing in infants and to identify diagnostic biomarkers, we analyzed the bronchial bacterial microbiota of infants with recurrent wheezing and with or without atopic diseases using a systems biology approach.MethodsBacterial communities in bronchoalveolar lavage samples from 15 atopic wheezing infants, 15 non-atopic wheezing infants, and 18 foreign body aspiration control infants were characterized using 16S rRNA gene sequencing. The bacterial composition and community-level functions inferred from between-group differences from sequence profiles were analyzed.ResultsBoth α- and β-diversity differed significantly between the groups. Compared to non-atopic wheezing infants, atopic wheezing infants showed a significantly higher abundance in two phyla (Deinococcota and unidentified bacteria) and one genus (Haemophilus) and a significantly lower abundance in one phylum (Actinobacteria). The random forest predictive model of 10 genera based on OTU-based features suggested that airway microbiota has diagnostic value for distinguishing atopic wheezing infants from non-atopic wheezing infants. PICRUSt2 based on KEGG hierarchy (level 3) revealed that atopic wheezing-associated differences in predicted bacterial functions included cytoskeleton proteins, glutamatergic synapses, and porphyrin and chlorophyll metabolism pathways.ConclusionThe differential candidate biomarkers identified by microbiome analysis in our work may have reference value for the diagnosis of wheezing in infants with atopy. To confirm that, airway microbiome combined with metabolomics analysis should be further investigated in the future.
Reverse cardiac remodeling in patients undergoing combination therapy of transcatheter mitral valve repair
Authors: Yokoyama Hiroaki , Ruf Tobias Friedrich , Geyer Martin , Tamm Alexander R. , Da Rocha E Silva Jaqueline Grace , Gößler Theresa Ann Maria , Zirbs Julia , Schwidtal Ben , Münzel Thomas , von Bardeleben Ralph Stephan 
Published: February 2023

AimsFor patients with severe mitral valve regurgitation (MR), different kinds of transcatheter mitral valve repair (TMVr) exist, targeting the leaflets, annulus, and chordae. The concomitant combination (COMBO) therapy of TMVrs is rarely used as treatment, and there are very few publications about this therapeutic strategy. We evaluated the effect of COMBO-TMVr on the cardiac left chambers and clinical data, including survival.MethodsWe included 35 patients at high risk who underwent concomitant sequential transcatheter mitral valve edge-to-edge repair (M-TEER) and another TMVr for severe MR in our hospital between March 2015 and April 2018. Of these, 13 had adequate follow-up transthoracic echocardiography (TTE) up to around 1 year after the procedure.ResultsSurvival for all patients was 83% at 1 year, 71% at 2 years, and 63% at 3 years, respectively. In the 13 patients with adequate TTE follow-up, M-TEER plus either Cardioband (n = 4), Carillon Mitral Contour System (n = 7), or Neochord (n = 2) were used, respectively. Ten patients had secondary, and three patients primary MR. After 1 year, changes [median (Q1, Q3)] of left ventricular (LV) end-systolic diameter of −9.9 cm (−11.1, 0.4), LV end-diastolic diameter of −3.3 cm (−8.5, 0.0), LV end-systolic volume (LVESV) of −17.4 mL (−32.6, −0.4), LV end-diastolic volume (LVEDV) of −13.5 mL (−15.9, −3.2), LV mass of −19.5 g (−24.2, −7.6), and left atrial volume (LAV) index (LAVi) of −16.4 mL (−23.3, −11.3) were observed. A significant reduction was also seen in the change ratios of LVESV, LVEDV, LV mass, and LAVi, respectively.ConclusionWe found that COMBO therapy of TMVr seems feasible and may support reverse remodeling of left cardiac chambers during 1 year after the procedure in a cohort of patients at high risk.
Burden and trend of cardiovascular diseases among people under 20 years in China, Western Pacific region, and the world: An analysis of the global burden of disease study in 2019
Authors: Zhang Yue , Lin Changjian , Liu Ming , Zhang Wei , Xun Xiaoyun , Wu Jinyi , Li Xiaopan , Luo Zheng 
Published: February 2023

ObjectivesCardiovascular disease (CVD) is a global public health concern, but its disease burden and trend have been poorly studied in people younger than 20 years. This study aimed to fill this gap by evaluating the CVD burden and trend in China, Western Pacific Region, and the world from 1990 to 2019.MethodsWe applied the 2019 Global Burden of Diseases (GBD) analytical tools to compare the incidence, mortality, and prevalence of CVD, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs) among people younger than 20 years from 1990 to 2019 in China, the Western Pacific Region, and the world. The trends of disease burden between 1990 and 2019 evaluated using the average annual percent change (AAPC) and the 95% uncertainty interval (UI) were reported.ResultsGlobally, in 2019, there were 2.37 (95% UI: 1.82 to 3.05) million incidence of CVD, 16.85 (95% UI: 12.56 to 22.03) million prevalence of CVD, and 74386.73 (95% UI: 64543.82 to 86310.24) deaths due to CVD among people under 20 years of age. The trends for DALYs decreased among children and adolescents in China, Western Pacific Region, and the world (AAPC = −4.29, 95% CI: −4.38% to −4.20%; AAPC = −3.37, 95% CI: −3.48% to −3.26%; AAPC = −2.17, 95% CI: −2.24% to −2.09%; p &lt; 0.001, respectively) between 1990 and 2019. With the increase in age, the AAPC values of mortality, YLLs, and DALYs showed a notable downward trend. The AAPC values of mortality, YLLs, and DALYs in female patients were significantly greater than those in male patients. For all subtypes of CVD, the AAPC values showed a downward trend, with the largest reduction observed for stroke. From 1990 to 2019, a decline in the DALY rate for all CVD risk factors was observed, with a significant decrease in environmental/occupational risk factors.ConclusionOur study shows a decline in the burden and trend of CVD among people younger than 20 years, which reflects the success in reducing disability, premature death, and the early incidence of CVD. More effective and targeted preventive policies and interventions aimed at mitigating preventable CVD burden and addressing risk factors from childhood are urgently needed.
High triglyceride–glucose index is associated with poor cardiovascular outcomes in Chinese acute coronary syndrome patients without diabetes mellitus who underwent emergency percutaneous coronary intervention with drug-eluting stents
Authors: Zhang Yong , Chu Chao , Zhong Zhong , Luo Yong-bai , Ning Fei-fei , Guo Ning 
Published: February 2023

BackgroundPrevious research has supported the association between the triglyceride–glucose index (TyG index) and the incidence and prognosis of cardiovascular disease. However, the association between the TyG index and the prognosis of patients with acute coronary syndrome (ACS) without diabetes mellitus (DM) who underwent emergency percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) has not been thoroughly investigated, and these patients may easily be neglected. Therefore, this study aimed to investigate the association between the TyG index and major adverse cardiovascular and cerebrovascular events (MACCEs) in Chinese ACS patients without DM who underwent emergency PCI with DES.MethodsThe total number of ACS patients without DM who underwent emergency PCI with DES for this study was 1650. Ln [fasting triglycerides (mg/dL) ×fasting plasma glucose (mg/dL)/2] is the formula used to calculate the TyG index. According to the TyG index, we classified the patients into two groups. The frequency of the following endpoint events was calculated and compared between the two groups: all-cause death, non-fatal myocardial infarction (MI), non-fatal ischemia stroke, ischemia-driven revascularization and cardiac rehospitalization.ResultsAfter a median of 47 months of follow-up [47 (40, 54)], 437 (26.5%) endpoint events were recorded in total. The TyG index was further demonstrated to be independent of MACCE by multivariable Cox regression analysis (hazard ratio [HR], 1.493; 95% confidence interval [CI], 1.230–1.812; p&lt;0.001). The TyG index≥7.08 group had a considerably greater incidence of MACCE (30.3% vs. 22.7% in the TyG index&lt;7.08 group, p&lt;0.001), cardiac death (4.0% vs. 2.3% in the TyG index&lt;7.08 group, p=0.047), and ischemia-driven revascularization (5.7% vs. 3.6% in the TyG index&lt;7.08 group, p=0.046) than the TyG index&lt;7.08 group. Between the two groups, there was no discernible difference in all-cause death (5.6% vs. 3.8% in the TyG index&lt;7.08 group, p=0.080), non-fatal MI (1.0% vs. 0.2% in the TyG index&lt;7.08 group, p=0.057), non-fatal ischemic stroke (1.6% vs. 1.0% in the TyG index&lt;7.08 group, p=0.272), and cardiac rehospitalization (16.5% vs. 14.1% in the TyG index&lt;7.08 group, p=0.171).ConclusionFor ACS patients without DM who received emergency PCI with DES, the TyG index might be an independent predictor of MACCE.
Establishment and validation of a nomogram model for predicting distant metastasis in medullary thyroid carcinoma: An analysis of the SEER database based on the AJCC 8th TNM staging system
Authors: Chen Zhufeng , Mao Yaqian , You Tingting , Chen Gang 
Published: February 2023

ObjectiveMedullary thyroid carcinoma (MTC) patients with distant metastases frequently present a relatively poor survival prognosis. Our main purpose was developing a nomogram model to predict distant metastases in MTC patients.MethodsThis was a retrospective study based on the Surveillance, Epidemiology, and End Results (SEER) database. Data of 807 MTC patients diagnosed from 2004 to 2015 who undergone total thyroidectomy and neck lymph nodes dissection was included in our study. Independent risk factors were screened by univariate and multivariate logistic regression analysis successively, which were used to develop a nomogram model predicting for distant metastasis risk. Further, the log‐rank test was used to compare the differences of Kaplan-Meier curves of cancer-specific survival (CSS) in different M stage and each independent risk factor groups.ResultsFour clinical parameters including age &gt; 55 years, higher T stage (T3/T4), higher N stage (N1b) and lymph node ratio (LNR) &gt; 0.4 were significant for distant metastases at the time of diagnosis in MTC patients, and were selected to develop a nomogram model. This model had satisfied discrimination with the AUC and C-index of 0.894, and C-index was confirmed to be 0.878 through bootstrapping validation. A decision curve analysis (DCA) was subsequently made to evaluate the feasibility of this nomogram for predicting distant metastasis. In addition, CSS differed by different M stage, T stage, N stage, age and LNR groups.ConclusionsAge, T stage, N stage and LNR were extracted to develop a nomogram model for predicting the risk of distant metastases in MTC patients. The model is of great significance for clinicians to timely identify patients with high risk of distant metastases and make further clinical decisions.