bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort
Authors: Salmen Anke , Hoepner Robert , Fleischer Vinzenz , Heldt Milena , Gisevius Barbara , Motte Jeremias , Ruprecht Klemens , Schneider Ruth , Fisse Anna Lena , Grüter Thomas , Lukas Carsten , Berthele Achim , Giglhuber Katrin , Flaskamp Martina , Mühlau Mark , Kirschke Jan , Bittner Stefan , Groppa Sergiu , Lüssi Felix , Bayas Antonios , Meuth Sven , Heesen Cristoph , Trebst Corinna , Wildemann Brigitte , Then Bergh Florian , Antony Gisela , Kümpfel Tania , Paul Friedemann , Nischwitz Sandra , Tumani Hayrettin , Zettl Uwe , Hemmer Bernhard , Wiendl Heinz , Zipp Frauke , Gold Ralf 
Published: September 2023

Background: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce. Objectives: To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort. Design: Cross-sectional analysis within a multicenter observational study. Methods: Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were available for n = 327 patients. Association of demographic factors, MS characteristics and risk factors [sex, age, smoking, disease course, presence of current relapse, expanded disability status scale (EDSS) score, fatigue (fatigue scale motor cognition), 25-OH-VD serum concentration, EBV nuclear antigen-1 IgG (EBNA1-IgG) serum levels] and depressive symptoms (Beck Depression Inventory-II, BDI-II) was tested as a primary outcome by multivariable linear regression. Non-parametric correlation and group comparison were performed for associations of MRI parameters and depressive symptoms. Results: Mean age was 34.3 years (95% confidence interval: 33.6–35.0). The female-to-male ratio was 2.3:1. At least minimal depressive symptoms (BDI-II > 8) were present in n = 256 (32.8%), 25-OH-VD deficiency (<20 ng/ml) in n = 398 (51.0%), n = 246 (31.5%) participants were smokers. Presence of current relapse [coefficient ( c) = 1.48, p = 0.016], more severe fatigue ( c = 0.26, p < 0.0001), lower 25-OH-VD ( c = −0.03, p = 0.034) and smoking ( c = 0.35, p = 0.008) were associated with higher BDI-II scores. Sex, age, disease course, EDSS, month of visit, EBNA1-IgG levels and brain volumes at baseline were not. Conclusion: Depressive symptoms need to be assessed in early MS. Patients during relapse seem especially vulnerable to depressive symptoms. Contributing factors such as fatigue, vitamin D deficiency and smoking, could specifically be targeted in future interventions and should be investigated in prospective studies.
The role of ‘artificial intelligence, machine learning, virtual reality, and radiomics’ in PCNL: a review of publication trends over the last 30 years
Authors: Nedbal Carlotta , Cerrato Clara , Jahrreiss Victoria , Castellani Daniele , Pietropaolo Amelia , Galosi Andrea Benedetto , Somani Bhaskar Kumar 
Published: September 2023

Introduction: We wanted to analyze the trend of publications in a period of 30 years from 1994 to 2023, on the application of ‘artificial intelligence (AI), machine learning (ML), virtual reality (VR), and radiomics in percutaneous nephrolithotomy (PCNL)’. We conducted this study by looking at published papers associated with AI and PCNL procedures, including simulation training, with preoperative and intraoperative applications. Materials and Methods: Although MeSH terms research on the PubMed database, we performed a comprehensive review of the literature from 1994 to 2023 for all published papers on ‘AI, ML, VR, and radiomics’ in ‘PCNL’, with papers in all languages included. Papers were divided into three 10-year periods: Period 1 (1994–2003), Period 2 (2004–2013), and Period 3 (2014–2023). Results: Over a 30-year timeframe, 143 papers have been published on the subject with 116 (81%) published in the last decade, with a relative increase from Period 2 to Period 3 of +427% ( p = 0.0027). There was a gradual increase in areas such as automated diagnosis of larger stones, automated intraoperative needle targeting, and VR simulators in surgical planning and training. This increase was most marked in Period 3 with automated targeting with 52 papers (45%), followed by the application of AI, ML, and radiomics in predicting operative outcomes (22%, n = 26) and VR for simulation (18%, n = 21). Papers on technological innovations in PCNL ( n = 9), intelligent construction of personalized protocols ( n = 6), and automated diagnosis ( n = 2) accounted for 15% of publications. A rise in automated targeting for PCNL and PCNL training between Period 2 and Period 3 was +247% ( p = 0.0055) and +200% ( p = 0.0161), respectively. Conclusion: An interest in the application of AI in PCNL procedures has increased in the last 30 years, and a steep rise has been witnessed in the last 10 years. As new technologies are developed, their application in devices for training and automated systems for precise renal puncture and outcome prediction seems to play a leading role in modern-day AI-based publication trends on PCNL.
Ulnar Variance in Athletes: A Scoping Review
Authors: Scigliano Noah M. , McSweeny Kareena F. , Garcia Fleury Ignacio , Buckwalter Joseph A. 
Published: September 2023

Context: Ulnar variance (UV) is a measurement of the relative locations of the radius and ulna that may become perturbed in athletic populations. Positive UV can be associated with wrist pathologies often treated conservatively or surgically and may result in interruption of sports participation. Objective: This scoping review aims to summarize diagnostic measures of UV in athletes, describe its relation to separate wrist conditions, and present treatment strategies for symptomatic UV. Data Sources: A systematic search was created and modified for PubMed, CINAHL, Embase, and SPORTDiscus including articles from inception until February 2, 2022. Study Selection: Articles including UV characterization, imaging modality style, and an athletic population were searched across multiple databases. Study Design: A scoping review was designed to identify the methods for imaging UV in athletic populations following the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Level of Evidence: Level 4. Data Extraction: The specific athletic population, imaging modality, measurement style, wrist pathology association, and surgical management of UV were extracted. Results: A total of 4321 records were screened independently for eligibility: 22 met inclusion criteria. Eight sports comprised the analysis. All studies referenced conventional radiography to diagnose UV; 50% specified the posteroanterior, 18.2% anteroposterior, and 13.6% pronated, gripping radiographs. Hafner’s method (7×), Palmer’s technique (2×), and the method of perpendiculars (3×) were used to measure UV. Athletes displayed more positive UV than nonathletes and UV became more positive over time in longitudinal studies. Triangular fibrocartilage complex tears, focal lunate necrosis, and ulnar abutment were associated with positive UV. Ulnar shortening osteotomy was the most performed operation for positive UV. Conclusion: Conventional radiography is the gold standard for imaging UV in athletes. Hafner’s method is the most commonly used radiograph measurement technique. Wrist pathology in athletic populations may indicate positive UV in need for operative management.
Experimental evaluation of the thermal effect on dynamic behavior of travertine rock
Authors: Noorian-Bidgoli Majid , Behnia Behnam 
Published: September 2023

When an engineering structure regarding a rock is affected by dynamic loads (due to the occurrence of natural hazards, such as earthquakes and landslides, or man-made hazards, such as explosions or impacts), correct prediction of changes in the strength behavior and deformability of the rock relative to its static state is necessary for reducing the damages and costs. On the other hand, rocks are always influenced by environmental conditions, such as temperature changes due to fire and weather during their lifetime, which should be considered when using them. In these cases, the mechanical behavior of the rock can usually be determined under different loading and environmental conditions using stress–strain curves. This study investigates rocks’ dynamic strength and deformability behavior at different loading rates and temperatures. For this purpose, 30 travertine rock samples from the Torshab mine, located in the Markazi province of Iran, were first heated up to 100°C, 200°C, 400°C, 800°C, and 1000°C (six temperatures), and then subjected under the impact pressure with different loading rates from (five) 11 m/s to 15 m/s using the split Hopkinson pressure bar test. Comparing the obtained dynamic stress–strain curve shows that at a constant loading rate, increasing the temperature, especially at higher temperatures, reduces the dynamic strength and increases the rock’s deformability. Moreover, in all cases, at a constant temperature, increasing the loading rate, especially at higher rates, increases the rock’s dynamic strength and deformability.
Improving mycetoma case detection through the training of community health workers in Northern Uganda: protocol for a stepped-wedge cluster-randomized trial
Authors: Kibone Winnie , Semulimi Andrew Weil , Kwizera Richard , Bongomin Felix 
Published: September 2023

Introduction: The World Health Organization acknowledges the need for countries to incorporate neglected tropical disease care into their routine health care system. However, low detection rates and late presentation of mycetoma to health facilities have been observed in endemic countries, including Uganda. Objective: To empower community health workers (CHWs) in Northern Uganda to recognize and refer suspects of mycetoma to health facilities. Design: This will be a stepped-wedge cluster-randomized trial based in Gulu and Pader districts over a period of 9 months with sequential crossover from intervention phase to the control phase at different time points until both districts are exposed to the intervention. Methods and Analysis: The study will leverage on the ongoing partnership between Northern Uganda Medical Mission and the Uganda Ministry of Health that has trained over 300 CHWs in Gulu and Pader. The study evaluation will be done using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework. The expected outcome of the study is increased detection and referral of suspects of mycetoma. Data will be analyzed using STATA 17.0 and Friedman statistics or Analysis of Variance to determine increase in case identifications and referrals. Ethics and Registration: The study was approved by Mulago Hospital Research and Ethics Committee (MHREC 2406) and registered with Pan African Clinical Trial Registry (PACTR202301534749787). Dissemination: The results from this trial will be published in a peer-reviewed journal. In addition, the findings will be shared at conferences, with funders, and at other research meetings.
Correlations of demographic factors and hygiene factors with face mask wearing during the COVID-19 pandemic and suggestion for future research: A cross-sectional study of adults in Malaysia
Authors: Looi Kim Hoe 
Published: September 2023

Background: Despite the many touted benefits of community-wide face mask wearing, numerous communication campaigns and mandates, some people still refuse or fail to wear face masks in public settings. Hence, exposing themselves and others to the risk of infection by the severe acute respiratory syndrome coronavirus 2 and raise the potential for public healthcare systems to become overwhelmed once again. This study investigates demographic and hygiene factors related to propensity of face mask wearing in public settings. Design and methods: The self-administered online questionnaire contained the independent variables (demographic and hygiene factors) and the outcome variable (frequency of face mask wearing). Participants were recruited through convenience and snowball sampling techniques. Seven hundred and eight responses were collected from Malaysian adults between May and June 2020. The demographic characteristics of participants, differences in the frequency of face mask wearing across demographic factors and hierarchical multiple regression were analyzed. Results: The propensity of face mask wearing differs by gender. The hierarchical multiple regression revealed that being female, having personal protective equipment available and frequently washing hands were positively correlated with the frequency of face mask wearing. Moreover, the availability of personal protective equipment and the frequency of hand washing accounted for greater variation of the frequency of face mask wearing than gender. Conclusion: Future studies should adopt established psychosocial models in conjunction with normative and cultural factors for a better understanding of underlying motivations to engage in preventive health behaviors to shape improved hygienic and societal precautionary protective behaviors in different contexts.
Perceived Use Behavior of Social Networking Sites Among the Healthcare Students in India
Authors: Sobaih Abu Elnasr E. , Baquee Abdul , Palla Ishfaq Ahmad , Munshi Shamim Aktar 
Published: September 2023

Introduction The use of social networking sites (SNSs) is growing among higher education students, including healthcare students. Nonetheless, limited research has examined the perceived use behavior among healthcare students in developing countries such as India. Objective This study attempts to assess the use behavior of SNSs by undergraduate students in the fields of nursing and pharmacy in India through the lens of Connectivism and New Social Learning theories. Method The study used a Google form to collect data through an online questionnaire. A sample of 483 participants included 258 Bachelor of Science in Nursing students, 161 General Nursing and Midwifery students, and 64 Bachelor of Pharmacy students from various Indian nursing and pharmacy schools. Results The majority of the respondents prefer to use SNSs for several purposes such as watching academic videos on YouTube, sharing their ideas, thoughts, and current development in their respective fields through WhatsApp, getting job-related information from different Facebook pages, etc. A substantial number of nursing students believed that these SNSs help them build relationships with professionals across the country. At the same time, many students also indicated that extensive use of SNSs might cause sleep difficulties, data privacy concerns, and a lack of focus while studying. Conclusion To have an impact on how SNSs are used in healthcare education, more attention should be paid to build connectivism between educators and their students on social learning environment, which the findings of this study's suggestions could be put into practice.
In vitro and in vivo toxicity of carbon dots with different chemical compositions
Authors: Kuznietsova Halyna , Géloën Alain , Dziubenko Nataliia , Zaderko Alexander , Alekseev Sergei , Lysenko Vladimir , Skryshevsky Valeriy 
Published: September 2023

AbstractCarbon dots (CDs) are easy-obtained nanoparticles with wide range of biological activity; however, their toxicity after prolonged exposure is poorly investigated. So, in vitro and in vivo toxicity of CDs with the surfaces enriched with hydroxylated hydrocarbon chains and methylene groups (CD_GE), carboxyl and phenol groups accompanied with nitrogen (CD_3011), trifluoromethyl (CDF19) or toluidine and aniline groups (CDN19) were aimed to be discovered. CDs’ in vitro toxicity was assessed on A549 cells (real-time cell analysis of impedance, fluorescence microscopy) after 24 h of incubation, and we observed no changes in cell viability and morphology. CDs’ in vivo toxicity was assessed on C57Bl6 mice after multiple dosages (5 mg/kg subcutaneously) for 14 days. Lethality (up to 50%) was observed in CDN19 and CD_3011 groups on different days of dosing, accompanied by toxicity signs in case of CD_3011. There were no changes in serum biochemical parameters except Urea (increased in CDF19 and CD_3011 groups), nor substantial kidney, liver, and spleen injuries. The most impactful for all organs were also CD_3011 and CDF19, causing renal tubule injury and liver blood supply violation. Thus, CDs with a surface enriched with oxygen- and nitrogen-containing functional groups might be toxic after multiple everyday dosing, without, however, significant damages of internal organs in survived animals.
Associations between velamentous or marginal cord insertion and risk of adverse perinatal outcomes in twin pregnancies: a retrospective cohort study
Authors: Wen Li , Zhong Qimei , Mei Lingwei , Gao Li , Lan Xia , Xiong Jing , Luo Shujuan , Wang Lan 
Published: September 2023

Abstract
Background
Velamentous cord insertion (VCI) and marginal cord insertion (MCI) are well-known risk factors for adverse perinatal outcomes in singleton pregnancies. However, the potential links between VCI or MCI and perinatal outcomes in twin pregnancies have yet to be systematically evaluated. This study aimed to investigate the relationships between VCI or MCI and perinatal outcomes in twin pregnancies.

Methods
This retrospective single-center cohort study included women with twin pregnancies who gave birth in a tertiary hospital in Southwest, China between January 2017 and December 2022. VCI and MCI were identified by abdominal ultrasound and confirmed after placental delivery. Logistic regression, multinomial logit regression and generalized estimation equation models were used to evaluate the association between VCI or MCI and perinatal outcomes.

Results
A total of 3682 twin pregnancies were included, including 100 (2.7%) pregnancies with VCI and 149 (4.0%) pregnancies with MCI. Compared to pregnancies with normal cord insertion, both monochorionic and dichorionic pregnancies with VCI were associated with an increased risk of preterm delivery 32–34 weeks (aRRR 2.94, 95% CI 1.03–8.39; aRRR 2.55, 95% CI 1.19–5.46, respectively), while pregnancies with MCI were not associated with preterm delivery. VCI was associated with a higher incidence of placental previa (aOR 6.36, 95% CI 1.92–21.04) in monochorionic pregnancies and placental accreta (aOR 1.85, 95% CI 1.06–3.23) in dichorionic pregnancies. MCI was associated with an increased risk of preeclampsia (aOR 3.07, 95% CI 1.49–6.32), intertwin birthweight discordance ≥ 20% (aOR 2.40, 95% CI 1.08–5.60) and selective fetal growth restriction (aOR 2.46, 95% CI 1.08–5.60) in monochorionic pregnancies and small-for-gestational age neonates (aOR 1.97, 95% CI 1.24–3.14) in dichorionic pregnancies.

Conclusions
VCI was associated with an increased risk of preterm delivery in twin pregnancies irrespective of chorionicity, whereas MCI was associated with an increased preeclampsia risk, significant intertwin birthweight discordance in monochorionic pregnancies and small-for-gestational age neonates in dichorionic pregnancies.
A rare presentation of orbital spindle cell carcinoma a case report and brief review of the literature
Authors: Tehrani Mansooreh Jamshidian , Rashidinia Ali , Amoli Fahimeh Asadi , Esfandiari Amirreza 
Published: September 2023

Abstract
Background
To describe a case of orbital spindle cell carcinoma which presented with limbal ischemia and briefly review the literature.

Methods
Retrospective case report and brief literature review.

Results
A 61-year old man presented with blepharoptosis, periorbital pain, decreased vision and limbal ischemia. He did not mention any previous illness and did not take any kind of drugs. Imaging revealed an orbital mass that was positive for SMA, Vimentin and CD99 and negative for S100. We treated the patient with chemotherapy and followed him for other complications that occurred throughout disease course.

Conclusion
Spindle cell carcinomas are a rare variant of squamous cell carcinoma (SCC) with dual malignant histologic differentiation of squamous and mesenchymal cells. Few cases of orbital spindle cell carcinoma have been reported, which have been either secondary to distant metastasis or regional spread. In this study, we have reported the first case of primary orbital spindle cell carcinoma presenting with limbal ischemia. Further studies are needed to describe the different clinical presentations and management strategies of this rare clinical entity.
A comparative observational study on intrasphincteric injections with Botulinum toxin vs. enteral neuromodulation in chronic refractory constipation
Authors: Walther Mona , Müller Hanna , Weiß Christel , Carbon Roman , Diez Sonja , Besendörfer Manuel 
Published: September 2023

Abstract
Purpose
Botulinum toxin injections in the anal sphincter apparatus (Botox) and enteral neuromodulation (ENM) are options for treatment of refractory chronic constipation. We present a retrospective comparative observational study.

Patients and methods
From 2014 to 2022, pediatric patients with chronic constipation were either treated with Botox or ENM with continuation of conservative treatment. Comparison was conducted regarding the primary outcome variables defecation frequency, stool consistency, and abdominal pain. Secondary outcomes were fecal incontinence, enuresis, change of medication and safety of treatment.

Results
19 Botox patients (10 boys, 9 girls, 12 patients with Hirschsprung disease (HD), 7 patients with functional constipation (FC)) were compared to 24 ENM patients (18 boys, 6 girls, 12 HD patients, 7 FC patients). Groups differed significantly in age (5.0 years (Botulinum toxin) and 6.5 years (ENM), mean values, p-value 0.008). Improvement of constipation was seen in 68% (n = 13/19) of Botox and 88% (n = 21/24) of ENM patients (p = 0.153). Influence of etiology on therapeutic effects was not observed. Complications were minor.

Conclusions
Botox and ENM can be considered as valuable and effective treatment options in refractory chronic constipation. Prospective, large-population studies should be designed to enable improved evidence.