bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the genetic basis of resistance to soybean cyst nematode combining IBD and association mapping
Authors: Tian Yu , Li Delin , Wang Xueqing , Zhang Hao , Wang Jiajun , Yu Lijie , Guo Changhong , Luan Xiaoyan , Liu Xinlei , Li Hongjie , Reif Jochen C. , Li Ying-hui , Qiu Li-juan 
Published: March 2023

AbstractKey messageIBD analysis clarified the dynamics of chromosomal recombination during the ZP pedigree breeding process and identified ten genomic regions resistant to SCN race3 combining association mapping.AbstractSoybean cyst nematode (SCN,Heterodera glycinesIchinohe) is one of the most devastating pathogens for soybean production worldwide. The cultivar Zhongpin03-5373 (ZP), derived from SCN-resistant progenitor parents, Peking, PI 437654 and Huipizhi Heidou, is an elite line with high resistance to SCN race3. In the current study, a pedigree variation map was generated for ZP and its ten progenitors using 3,025,264 high-quality SNPs identified from an average of 16.2 × re-sequencing for each genome. Through identity by decent (IBD) tracking, we showed the dynamic change of genome and detected important IBD fragments, which revealed the comprehensively artificial selection of important traits during ZP breeding process. A total of 2,353 IBD fragments related to SCN resistance including SCN-resistant genesrhg1,rhg4andNSFRAN07were identified based on the resistant-related genetic paths. Moreover, 23 genomic regions underlying resistance to SCN race3 were identified by genome-wide association study (GWAS) in 481 re-sequenced cultivated soybeans. Ten common loci were found by both IBD tracking and GWAS analysis. Haplotype analysis of 16 potential candidate genes suggested a causative SNP (C/T, − 1065) located in the promoter ofGlyma.08G096500and encoding a predicted TIFY5b-related protein on chr8 was highly correlated with SCN race3 resistance. Our results more thoroughly elucidated the dynamics of genomic fragments during ZP pedigree breeding and the genetic basis of SCN resistance, which will provide useful information for gene cloning and the development of resistant soybean cultivars using a marker-assisted selection approach.
The axiom of choice in metric measure spaces and maximal $$\delta $$-separated sets
Authors: Dybowski Michał , Górka Przemysław 
Published: March 2023

AbstractWe show that the Axiom of Countable Choice is necessary and sufficient to prove that the existence of a Borel measure on a pseudometric space such that the measure of open balls is positive and finite implies separability of the space. In this way a negative answer to an open problem formulated in Górka (Am Math Mon 128:84–86, 2020) is given. Moreover, we study existence of maximal $$\delta $$
δ
-separated sets in metric and pseudometric spaces from the point of view the Axiom of Choice and its weaker forms.
On non-centered maximal operators related to a non-doubling and non-radial exponential measure
Authors: Nowak Adam , Sasso Emanuela , Sjögren Peter , Stempak Krzysztof 
Published: March 2023

AbstractWe investigate mapping properties of non-centered Hardy–Littlewood maximal operators related to the exponential measure $$d\mu (x) = \exp (-|x_1|-\cdots -|x_d|)dx$$

d
μ

(
x
)

=
exp
(
-
|

x
1

|
-
⋯
-
|

x
d

|
)
d
x

in $${\mathbb {R}}^d$$

R

d

. The mean values are taken over Euclidean balls or cubes ($$\ell ^{\infty }$$

ℓ
∞

balls) or diamonds ($$\ell ^1$$

ℓ
1

balls). Assuming that $$d \ge 2$$

d
≥
2

, in the cases of cubes and diamonds we prove the $$L^p$$

L
p

-boundedness for $$p>1$$

p
>
1

and disprove the weak type (1, 1) estimate. The same is proved in the case of Euclidean balls, under the restriction $$d \le 4$$

d
≤
4

for the positive part.
Field Assessment of Naled and Its Primary Degradation Product (Dichlorvos) in Aquatic Ecosystems Following Aerial Ultra-low Volume Application for Mosquito Control
Authors: Smith Cassandra D. , Hladik Michelle L. , Kuivila Kathryn M. , Waite Ian R. 
Published: March 2023

AbstractNaled, an organophosphate insecticide, is applied aerially at ultra-low volumes over aquatic ecosystems near Sacramento, California, USA, during summer months for mosquito control. Two ecosystem types (rice fields and a flowing canal) were sampled in 2020 and 2021. Naled and its primary degradation product (dichlorvos) were measured in water, biofilm, grazer macroinvertebrates, and omnivore/predator macroinvertebrates (predominantly crayfish). Maximum naled and dichlorvos concentrations detected in water samples one day after naled application were 287.3 and 5647.5 ng/L, respectively, which were above the U.S. Environmental Protection Agency’s aquatic life benchmarks for invertebrates. Neither compound was detected in water more than one day after the application. Dichlorvos, but not naled, was detected in composite crayfish samples up to 10 days after the last aerial application. Detections in water from the canal showed that the compounds were transported downstream of the target application area. Factors such as vector control flight paths, dilution, and transport through air and water likely affected concentrations of naled and dichlorvos in water and organisms from these aquatic ecosystems.
Graphical Abstract
Cardiac radiology in Europe: status and vision by the European Society of Cardiovascular Radiology (ESCR) and the European Society of Radiology (ESR)
Authors: Natale Luigi , Vliegenthart Rozemarijn , Salgado Rodrigo , Bremerich Jens , Budde Riccardo P. J. , Dacher Jean-Nicholas , Francone Marco , Kreitner Karl-Friedrich , Loewe Christian , Nikolaou Konstantin , Peebles Charles , Velthuis Birgitta K. , Catalano Carlo 
Published: March 2023

Abstract
Cardiac computed tomography (CT) and cardiac magnetic resonance imaging (MRI) are routine radiological examinations for diagnosis and prognosis of cardiac disease. The expected growth in cardiac radiology in the coming years will exceed the current scanner capacity and trained workforce. The European Society of Cardiovascular Radiology (ESCR) focuses on supporting and strengthening the role of cardiac cross-sectional imaging in Europe from a multi-modality perspective. Together with the European Society of Radiology (ESR), the ESCR has taken the initiative to describe the current status of, a vision for, and the required activities in cardiac radiology to sustain, increase and optimize the quality and availability of cardiac imaging and experienced radiologists across Europe.

Key Points
• Providing adequate availability for performing and interpreting cardiac CT and MRI is essential, especially with expanding indications.
• The radiologist has a central role in non-invasive cardiac imaging examinations which encompasses the entire process from selecting the best modality to answer the referring physician’s clinical question to long-term image storage.
• Optimal radiological education and training, knowledge of the imaging process, regular updating of diagnostic standards, and close collaboration with colleagues from other specialties are essential.
On the role of transverse motion in pseudo-steady gravity currents
Authors: Marshall C. R. , Dorrell R. M. , Keevil G. M. , Peakall J. , Tobias S. M. 
Published: March 2023

AbstractFlow in the body of gravity currents is typically assumed to be statistically two-dimensional, and cross-stream flow is often neglected (Simpson 1997; Meiburg et al. 2015). Here, we assess the validity of such assumptions using Shake-the-Box particle tracking velocimetry measurements of experimental gravity current flows. The resulting instantaneous, volumetric, whole-field velocity measurements indicate that cross-stream and vertical velocities (and velocity fluctuations) are equivalent in magnitude and thus are key to energy distribution and dissipation within the flow. Further, the presented data highlight the limitations of basing conclusions regarding body structure on a single cross-stream plane (particularly if that plane is central). Spectral analysis and dynamic mode decomposition of the fully three-dimensional, volumetric velocity data suggests internal waves within the current body that are associated with coherent three-dimensional motions in higher Reynolds number flows. Additionally, a potential critical layer at the height of the downstream velocity maximum is identified.
Systematic review of long term follow-up and transitional care in adolescents and adults with esophageal atresia - why is transitional care mandatory?
Authors: Brooks G. , Gazzaneo M. , Bertozzi M. , Riccipetitoni G. , Raffaele A. 
Published: March 2023

AbstractPurpose: to review recent literature concerning long-term health issues and transitional care in esophageal atresia (EA) patients. PubMed, Scopus, Embase and Web of Science databases were screened for studies regarding EA patients aged more than or equal to 11 years, published between August 2014 and June 2022. Sixteen studies involving 830 patients were analyzed. Mean age was 27.4 years (range 11–63). EA subtype distribution was: type C (48.8%), A (9.5%), D (1.9%), E (0.5%) and B (0.2%). 55% underwent primary repair, 34.3% delayed repair, 10.5% esophageal substitution. Mean follow-up was 27.2 years (range 11–63). Long-term sequelae were: gastro-esophageal reflux (41.4%), dysphagia (27.6%), esophagitis (12.4%), Barrett esophagus (8.1%), anastomotic stricture (4.8%); persistent cough (8.7%), recurrent infections (4.3%) and chronic respiratory diseases (5.5%). Musculo-skeletal deformities were present in 36 out of 74 reported cases. Reduced weight and height were detected in 13.3% and 6% cases, respectively. Impaired quality of life was reported in 9% of patients; 9.6% had diagnosis or raised risk of mental disorders. 10.3% of adult patients had no care provider. Meta-analysis was conducted on 816 patients. Estimated prevalences are: GERD 42.4%, dysphagia 57.8%, Barrett esophagus 12.4%, respiratory diseases 33.3%, neurological sequelae 11.7%, underweight 19.6%. Heterogeneity was substantial (> 50%). Conclusion: EA patients must continue follow-up beyond childhood, with a defined transitional-care path by a highly specialized multidisciplinary team due to the multiple long-term sequelae.

What is Known:• Survival rates of esophageal atresia patients is now more than 90% thanks to the improvements in surgical techniques and intensive care, therefore patients’ needs throughout adolescence and adulthood must be taken into account.

What is New:• This review, by summarizing recent literature concerning long term sequelae of esophageal atresia, may contribute to raise awareness on the importance of defining standardized protocols of transitional and adulthood care for esophageal atresia patients.
DynQ: a dynamic query engine with query-reuse capabilities embedded in a polyglot runtime
Authors: Schiavio Filippo , Bonetta Daniele , Binder Walter 
Published: March 2023

AbstractLanguage-integrated query (LINQ) frameworks offer a convenient programming abstraction for processing in-memory collections of data, allowing developers to concisely express declarative queries using popular programming languages. Existing LINQ frameworks rely on the type system of statically typed languages such as C$$^\sharp $$♯or Java to perform query compilation and execution. As a consequence of this design, they do not support dynamic languages such as Python, R, or JavaScript. Such languages are however very popular among data scientists, who would certainly benefit from LINQ frameworks in data-analytics applications. The gap between dynamic languages and LINQ frameworks has been partially bridged by the recent work DynQ, a novel query engine designed for dynamic languages. DynQ is language-agnostic, since it is able to execute SQL queries on all languages supported by the GraalVM platform. Moreover, DynQ can execute queries combining data from multiple sources, namely in-memory object collections as well as on-file data and external database systems. The evaluation of DynQ shows performance comparable with equivalent hand-optimized code, and in line with common data-processing libraries and embedded databases, making DynQ an appealing query engine for standalone analytics applications and for data-intensive server-side workloads. In this work, we extend DynQ addressing the problem of optimizing high-throughput workloads in the context of fluent APIs. In particular, we focus on applications which make use of data-processing libraries mostly for executing many queries on small batches of datasets, e.g., in micro-services, as well as applications which make use of data-processing libraries within recursive functions. For this purpose, we presentreusable compiled queries, a novel approach to query execution which allows reusing the same dynamically compiled code for different queries. As we show in our evaluation, thanks to reusable compiled queries, DynQ can also speed up applications that heavily use data-processing libraries on small datasets using a typical fluent API.
Expanding risk predictions of pesticide resistance evolution in arthropod pests with a proxy for selection pressure
Authors: Thia Joshua A. , Maino James , Kelly Alicia , Hoffmann Ary A. , Umina Paul A. 
Published: March 2023

AbstractChemical resistance in pest organisms threatens global food security and human health, yet resistance issues are mostly dealt with reactively. Predictive models of resistance risk provide an avenue for field practitioners to implement proactive pest management but require knowledge of factors that drive resistance evolution. Despite the importance of chemical selection pressure on resistance evolution, poor availability of chemical usage data has limited the use of a general multi-species measure of selection pressure in predictive models. We demonstrate the use of pesticide product registrations as a predictor of resistance status and potential proxy of chemical selection pressure. Pesticide product registrations were obtained for 427 USA and 209 Australian agricultural arthropod pests, for 42 and 39 chemical Mode of Action (MoA) groups, respectively. We constructed Bayesian logistic regressions of resistance status as a function of the number of pesticide product registrations and two ecological traits, phagy, and voltinism. Our models were well-supported with demonstrated power to discriminate between resistant and susceptible observations in both USA and Australian species sets using cross-validation. Importantly, we observed strong support for a positive association between pesticide products and resistance status. Our work expands the horizon for proactive management by quantitatively linking a proxy for selection pressure on pest species to different chemical MoAs, which can be combined with ecological information to build models of resistance evolution risk. Because pesticide product registrations can typically be obtained from publicly available data, we believe they have broad applicability for risk predictions in other agricultural pests, such as weeds and fungi, and to other geographical regions beyond the USA and Australia.
A simplified semi-quantitative procedure based on the SLIP model for landslide risk assessment: the case study of Gioiosa Marea (Sicily, Italy)
Authors: Gatto Michele Placido Antonio , Lentini Valentina , Montrasio Lorella , Castelli Francesco 
Published: March 2023

AbstractLandslide risk assessment is fundamental in identifying risk areas, where mitigation measures must be introduced. Most of the existing methods are based on susceptibility assessment strongly site-specific and require information often unavailable for damage quantification. This study proposes a simplified methodology, specific for rainfall-induced shallow landslides, that tries to overcome both these limitations. Susceptibility assessed from a physically-based model SLIP (shallow landslides instability prediction) is combined with distance derived indices representing the interference probability with elements at risk in the anthropized environment. The methodology is applied to Gioiosa Marea municipality (Sicily, south Italy), where shallow landslides are often triggered by rainfall causing relevant social and economic damage because of their interference with roads. SLIP parameters are first calibrated to predict the spatial and temporal occurrence of past surveyed phenomena. Susceptibility is then assessed in the whole municipality and validated by comparison with areas affected by slide movements according to the regional databases of historical landslides. It is shown that all the detected areas are covered by points where the SLIP safety factor ranges between 0 and 2. Risk is finally assessed after computation of distances from elements at risk, selected from the land use map. In this case, results are not well validated because of lack of details in the available regional hydrogeological plan, both in terms of extension and information. Further validation of the proposed interference indices is required, e.g., with studies of landslide propagation, which can also allow considerations on the provoked damage.
Identification of vitamin B12 producing bacteria based on the presence of bluB/cobT2 homologues
Authors: Dudko Darya , Milker Sofia , Holtmann Dirk , Buchhaupt Markus 
Published: March 2023

Abstract
Objectives
The objective of the study was to develop a strategy for the identification of new vitamin B12-producing species and to characterize their production capability using a fast and sensitive LC–MS/MS method developed in this study.

Results
Searching for homologues of the bluB/cobT2 fusion gene known to be responsible for the production of the active vitamin B12 form in P. freudenreichii was shown to be a successful strategy for the identification of new vitamin B12-producing strains. The analysis of the identified strains via LC–MS/MS showed the ability of Terrabacter sp. DSM102553, Yimella lutea DSM19828 and Calidifontibacter indicus DSM22967 to produce the active form of vitamin B12. Further analysis of vitamin B12 production capability of Terrabacter sp. DSM102553 in M9 minimal medium and peptone-based media revealed that the highest yield of 2.65 µg of vitamin B12 per g dry cell weight was obtained in M9 medium.

Conclusions
The proposed strategy enabled identification of Terrabacter sp. DSM102553, whose relatively high yields obtained in the minimal medium open new perspectives for the possible application of the strain for biotechnological vitamin B12 production.
A phase I dose-escalation study of SYHA1813, a VEGFR and CSF1R inhibitor, in patients with recurrent High-Grade Gliomas or Advanced Solid Tumors
Authors: Kang Zhuang , Li Shenglan , Lin Yi , Li Yongsheng , Mao Ying , Zhang Jing , Lei Ting , Wang Haidan , Su Yangzhi , Yang Yang , Qiu Jingbo , Li Wenbin 
Published: March 2023

AbstractSYHA1813 is a potent multikinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs)/colony-stimulating factor 1 receptor (CSF1R). This study aimed to evaluate the safety, pharmacokinetics (PK), and antitumor activity of escalating doses of SYHA1813 in patients with recurrent high-grade gliomas (HGGs) or advanced solid tumors. This study adopted a combination of accelerated titration and a 3 + 3 design for dose escalation, with a starting dose of 5 mg once daily. The dose escalation continued at successive dose levels until the maximum tolerated dose (MTD) was determined. A total of 14 patients were enrolled and treated, including 13 with WHO grade III or IV gliomas and 1 with colorectal cancer. Two patients experienced dose-limiting toxicities (grade 4 hypertension and grade 3 mucositis oral) at 30 mg SYHA1813. The MTD was defined as 15 mg once daily. Hypertension (n = 6, 42.9%) was the most frequent treatment-related adverse event. Among evaluable patients (n = 10), 2 (20%) patients achieved partial response, and 7 (70%) had stable disease. The exposure increased with increasing doses within the studied dose range of 5 to 30 mg. Biomarker assessments demonstrated significant reductions in the levels of soluble VEGFR2 (P = .0023) and increases in the levels of VEGFA (P = .0092) and placental growth factor (P = .0484). The toxicities of SYHA1813 were manageable, and encouraging antitumor efficacy was observed in patients with recurrent malignant glioma. This study is registered with the Chinese Clinical Trial Registry (www.chictr.org.cn/index.aspx; identifier ChiCTR2100045380).
Two’s company: first record of two free-swimming megamouth sharks, Megachasma pelagios (Lamniformes: Megachasmidae), off the California coast
Authors: Skelton Zachary R. , Kacev Dovi , Frable Benjamin W. , Chang Andrew , Costescu Valentin , Stabile David , Ebert David A. 
Published: March 2023

AbstractOn September 11, 2022, two megamouth sharks (Megachasma pelagios), estimated at 3.7–4.6 m TL, were observed swimming together near the surface about 39 km off the coast of San Diego, CA, USA. Megamouth sharks are rarely observed pelagic sharks, and the film from this encounter provided new insight into the social behavior of this species. We attempt to put the behavior of these two individuals into the context of past sightings, known megamouth shark biology, and with analogous behavior observed in other shark and pelagic fish species.
Elucidating the Associations Between Achievement Goals and Academic Dishonesty: a Meta-analysis
Authors: Fritz Tanja , González Cruz Hernán , Janke Stefan , Daumiller Martin 
Published: March 2023

AbstractAcademic dishonesty is a pervasive problem undermining the effectiveness of educational institutions. From a motivational perspective, researchers have proposed achievement goals as antecedents of academic dishonesty. Empirical findings corroborate the notion that mastery goals (focus on learning and competence development) are negatively linked to academic dishonesty. However, even though theoretical considerations suggest positive links between performance goals (focus on competence demonstration) and academic dishonesty, empirical findings are mixed. To provide a better understanding of how goals matter for academic dishonesty, we conducted three-level meta-analyses encompassing 163 effect sizes from 33 studies and a total of 19,787 participants. We found a disproportional use of correlational designs (using self-report measures of academic dishonesty) and personal goal measures (opposed to surrounding goal structures). Evidence of publication bias was not found. Our results confirmed the expected negative associations between mastery goals and academic dishonesty and revealed heterogenous findings for performance goals, with indications of positive associations within behavioral and intentional dishonesty measures, but not within self-reports. To further clarify the associations between achievement goals and academic dishonesty, we call for more methodological rigor in the measurement of goals and dishonesty as well as multi-methods approaches when investigating their interplay.