bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fight back against the stress: The effects of parental job insecurity on career networking behaviors of emerging adults
Authors: Wang Ruimeng , Lin Xinqi 
Published: April 2023

AbstractIntroductionThis study investigates whether and how parental job insecurity motivates emerging adults' career networking behaviors. Using the framework of ecological system theory, we particularly focus on the sequential mediating role that overparenting behavior and emerging adults' intolerance of uncertainty could play.MethodsWe recruit 741 fresh undergraduates (63.2% females) and their parents from the city of Jinan, Province Shandong in China. All of the participants are between the ages of 17 and 20 years. We apply a structural equation model using data obtained from multiple sources (i.e., fathers, mothers, and their children) at two time points to test our research model.Results and ConclusionsThe results from the structural equation model support the spillover effect of paternal and maternal job insecurity on overparenting behavior. Overparenting is significantly related to emerging adults' intolerance of uncertainty. In turn, emerging adults' intolerance of uncertainty is positively associated with their career networking behavior. The results also support the indirect effect, which demonstrates that parental job insecurity indirectly leads to emerging adults' career networking behavior via overparenting behavior and emerging adults' intolerance of uncertainty. This study builds on and extends existing research on parental job insecurity and career networking behavior by systematically bringing together the streams of research on youth development and organizational behavior. Specific theoretical implications and limitations are discussed as well.
Confining CO2 inside sI clathrate‐hydrates: The impact of the CO2–water interaction on quantized dynamics
Authors: Valdés Álvaro , Cabrera‐Ramírez Adriana , Prosmiti Rita 
Published: April 2023

AbstractWe report new results on the translational‐rotational (T‐R) states of the CO2 molecule inside the sI clathrate‐hydrate cages. We adopted the multiconfiguration time‐dependent Hartree methodology to solve the nuclear molecular Hamiltonian, and to address issues on the T‐R couplings. Motivated by experimental X‐ray observations on the CO2 orientation in the D and T sI cages, we aim to evaluate the effect of the CO2–water interaction on quantum dynamics. Thus, we first compared semiempirical and ab initio‐based pair interaction model potentials against first‐principles DFT‐D calculations for ascertaining the importance of nonadditive many‐body effects on such guest–host interactions. Our results reveal that the rotational and translational excited states quantum dynamics is remarkably different, with the pattern and density of states clearly affected by the underlying potential model. By analyzing the corresponding the probability density distributions of the calculated T‐R eigenstates on both semiempirical and ab initio pair CO2–water nanocage potentials, we have extracted information on the altered CO2 guest local structure, and we discussed it in connection with experimental data on the orientation of the CO2 molecule in the D and T sI clathrate cages available from neutron diffraction and solid‐state NMR studies, as well as in comparison with previous molecular dynamics simulations. Our calculations provide a very sensitive test of the potential quality by predicting the low‐lying T‐R states and corresponding transitions for the encapsulated CO2 molecule. As such spectroscopic observables have not been measured so far, our results could trigger further detailed experimental and theoretical investigations leading to a quantitative description of the present guest–host interactions.
Gender differences in perceived racism threat and activism during the Black Lives Matter social justice movement for Black young adults
Authors: Lafreniere Bianca , Audet Élodie C. , Kachanoff Frank , Christophe N. Keita , Holding Anne C. , Janusauskas Lauren , Koestner Richard 
Published: April 2023

AbstractA longitudinal study involving 455 Black young adults living in Canada investigated whether gender and autonomous motivation influenced the relationship between perceived racism threat and Black Lives Matter (BLM) activism, and whether BLM activism influenced life satisfaction over time. A moderated mediation analysis using PROCESS Macro Model 58 tested the indirect effect of autonomous motivation on the relationship between perceived racism threat and BLM activism varying by gender. Multiple linear regression assessed how well BLM activism predicted life satisfaction. Black women perceived greater racism threat than Black men related to increases in BLM activism via the influence of autonomous motivation. BLM activism had a positive influence on life satisfaction over time, regardless of gender. This research suggests Black young women are playing pivotal roles in the BLM movement and helps us understand how motivation may be influencing involvement and well‐being in social justice issues.
Follicular fluid exosomes regulate OVGP1 secretion in yak oviduct epithelial cells via autophagy in vitro
Authors: Wang Jinglei , Pan Yangyang , Wang Meng , Xu Ruihua , Han Xiaohong , Ma Rui , Zhao Ling , Zhang Tongxiang , Wang Yaying , Zhao Tian , Ding Tianyi , Baloch Abdul Rasheed , Wang Libin , Cui Yan , Yu Sijiu 
Published: April 2023

AbstractAfter mammalian ovulation, oocytes enter the oviduct, causing oocyte and oviduct changes. Some studies have shown that follicular fluid exosomes (FEVs) play an important role in this regulatory process, but the specific mechanism is remains unclear. Here, we investigate the effect of FEVs on autophagy and on the synthesis and secretion of oviductal glycoprotein 1 (OVGP1) in yak oviduct epithelial cells (OECs). We added FEVs to yak OECs and collected samples at intervals. The effect of autophagy on OVGP1 synthesis and secretion was detected by manipulating the level of autophagy in OECs. The results showed that autophagy gradually increased as early as 6 h after exosome intake level increased, and the increase was most obvious 24 h after. At that time, the synthesis and secretion of OVGP1 also reached its highest levels. When the autophagy level of OECs is changed through the PI3K/AKT/mTOR pathway, OVGP1 synthesis and secretion levels also change, along with the OVGP1 levels in oviduct exosomes also change. More importantly, the addition of FEVs treatment while using 3‐MA to inhibit the autophagy level in yak OECs did not change the synthesis and secretion level of OVGP1. Our results indicate that FEVs can affect the synthesis and secretion of OVGP1 by regulating the level of autophagy in OECs, and that the completion of this process may depend on the PI3K/AKT/mTOR pathway, indicating that exosomes and autophagy play important roles in the reproductive physiology of yak OECs. Our results provide new ideas in to characterizing the role of exosomes in yak reproduction.
Tilorone increases glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels
Authors: Kohler Zoltan M. , Trencsenyi Gyorgy , Juhasz Laszlo , Zvara Agnes , Szabo Judit P. , Dux Laszlo , Puskas Laszlo G. , Rovo Laszlo , Keller‐Pinter Aniko 
Published: April 2023

AbstractSkeletal muscle plays a major role in whole‐body glucose metabolism. Insulin resistance in skeletal muscle is characterized by decreased insulin‐stimulated glucose uptake resulting from impaired intracellular trafficking and decreased glucose transporter 4 (GLUT4) expression. In this study, we illustrated that tilorone, a low‐molecular‐weight antiviral agent, improves glucose uptake in vitro and in vivo. Tilorone increased bone morphogenetic protein (BMP) signaling in C2C12 myoblasts, the transcription of multiple BMPs (BMP2, BMP4, BMP7, and BMP14), Smad4 expression, and the phosphorylation of BMP‐mediated Smad1/5/8. The activation of Akt2/AS160 (TBC1D4) signaling, the critical regulator of GLUT4 translocation, was also increased, as well as the levels of GLUT4 and GLUT1, leading to enhanced uptake of the radioactively labeled glucose analog 18F‐fluoro‐2‐deoxyglucose (18FDG). However, this excess glucose content did not result in increased ATP formation by mitochondrial respiration; both basal and ATP‐linked respiration were diminished, thereby contributing to the induction of AMPK. In differentiated myotubes, AS160 phosphorylation and 18FDG uptake also increased. Moreover, tilorone administration further increased insulin‐stimulated phosphorylation of Akt2 and glucose uptake of myotubes indicating an insulin‐sensitizing effect. Importantly, during in vivo experiments, the systemic administration of tilorone resulted in increased 18FDG uptake of skeletal muscle, liver, and adipose tissue in C57BL/6 mice. Our results provide new perspectives for the treatment of type 2 diabetes, which has a limited number of treatments that regulate protein expression or translocation.
Part, III: Increasing odor detection performance after training with progressively leaner schedules of odor prevalence
Authors: DeChant Mallory T. , Aviles‐Rosa Edgar , Prada‐Tiedemann Paola , Hall Nathaniel J. 
Published: April 2023

AbstractPrior work has demonstrated canine search behavior and performance declines when challenged with infrequent target odors. The purpose of this study was to evaluate whether performance could be maintained in a low target odor prevalence context by explicitly training dogs through progressively leaner target odor schedules. In Experiment 1, nine control dogs were trained at 90% target prevalence rate. Nine experimental dogs were trained with progressively lower prevalence rates in 10% increments until reaching 20% prevalence with > 85% detection accuracy in the training context. Both groups were tested in the operational context at a 10% target odor prevalence. Experimental dogs had higher accuracy, hit percentage, and shorter search latency in the operational context compared with control dogs. In Experiment 2, twenty‐three operational dogs were challenged with a target frequency of 10%, which resulted in 67% accuracy. Control dogs were then trained with 90% target frequency, whereas experimental dogs received a progressively decreasing target rate from 90% to 20%. The dogs were rechallenged with target frequencies of 10, 5, and 0%. Experimental dogs outperformed control dogs (93% vs. 82% accuracy) highlighting the effect of explicit training for infrequent targets.
Engineering climate for marginalized groups: Connections to peer relations and engineering identity
Authors: Davis Susannah C. , Nolen Susan Bobbitt , Cheon Naeun , Moise Elba , Hamilton Eric William 
Published: April 2023

AbstractBackgroundA better understanding of departmental climate and its relationship to engineering identity is needed to diversify engineering and improve marginalized students' experiences.Purpose/HypothesisWe investigated whether undergraduate engineering students from 16 social identity groups perceived departmental climate differently from one another and examined psychological and behavioral factors contributing to these perceptions and their relationship to engineering identification.Design/MethodWe surveyed 398 undergraduate engineering students about departmental climate and engineering identity, testing structural models across race and gender. Qualitative analysis of open‐ended items complemented quantitative results.ResultsStudents rated climate for dominant identities (White, male, and/or US‐born) as more welcoming than for 14 nondominant identities, broadening the notion of “nondominant” identities in engineering. In structural models, invariant across race and gender, students' perceptions of bias, safety, and faculty support predicted climate ratings; peer relations and microaggressions predicted engineering identity. There were mean differences in perceptions across intersections of race and gender, but students in all groups perceived a climate gap favoring dominant identities. Open‐ended responses highlighted students' desire for a more diverse, inclusive program and the importance of peer relations.ConclusionsDepartmental climate can be less welcoming for engineering students with many different nondominant identities. Attending to both students' own social positioning and their perceptions of climate for other students can open opportunities for change in engineering departments. Results suggest that efforts to improve peer relations in group work could be important in promoting disciplinary identification in historically marginalized groups.
Machine annealing‐guided navigation of antihypertensive food peptide selectivity between human ACE N‐ and C‐domains in structurally interacting diversity space
Authors: Mei Li , Shang Shuyong , Wang Shaozhou , Ye Haiyang , Zhou Peng 
Published: April 2023

AbstractHuman angiotensin‐converting enzyme (ACE) is a well‐established druggable target for the treatment of hypertension (HTN), which contains two structurally homologous but functionally distinct N‐ and C‐domains. Selective inhibition of the C‐domain primarily contributes to the antihypertensive efficiency and can be exploited as medicinal agents and functional additives for regulating blood pressure with high safety. In this study, we used a machine annealing (MA) strategy to guide the navigation of antihypertensive peptides (AHPs) in structurally interacting diversity space with the two ACE domains based on their crystal/modeled complex structures and an in‐house protein‐peptide affinity scoring function, aiming to optimize the peptide selectivity for C‐domain over N‐domain. The strategy generated a panel of theoretically designed AHP hits with a satisfactory C‐over‐N (C > N) selectivity profile, from which several hits were found to have a good C > N selectivity, which is roughly comparable with or even better than the BPPb, a natural C > N‐selective ACE‐inhibitory peptide. Structural analysis and comparison of domain‐peptide noncovalent interaction patterns revealed that (i) longer peptides (>4 amino aids) generally exhibit stronger selectivity than shorter peptides (<4 amino aids), (ii) peptide sequence can be divided into two, section I (including peptide C‐terminal region) and section II (including peptide middle and N‐terminal regions); the former contributes to both peptide affinity (primarily) and selectivity (secondarily), while the latter is almost only responsible for peptide selectivity, and (iii) charged/polar amino acids confer to peptide selectivity relative to hydrophobic/nonpolar amino acids (that confer to peptide affinity).
Mindfulness and workplace safety: An integrative review
Authors: Liu Zihan , Hoff Kevin , Baranski Erica , Snyder Galen , Flin Rhona , Lindner Peggy , Spitzmueller Christiane 
Published: April 2023

AbstractMindfulness has recently gained popularity in applied settings to enhance workplace safety, especially in safety‐critical occupations such as healthcare and construction. In this review, we synthesize existing research across disciplines to establish a theoretical model of mindfulness and safety. Based on 32 empirical studies, we first summarize and critically analyze how mindfulness and safety are conceptualized and operationalized in the literature. We then consolidate empirical findings and conceptual arguments and draw upon the job demands–resources model to propose a theoretical model linking the basic benefits of mindfulness to safety‐related job demands. Specifically, we propose that mindfulness (a) improves detection of and responses to workplace risks and hazards, (b) enhances concentration and self‐monitoring of safety behaviors in cognitively demanding situations, and (c) facilitates more adaptive responses to emotional burdens. We further propose that the mindfulness–safety link can vary across boundary conditions, including personal and contextual characteristics. Our theoretical model serves as a foundation to integrate existing knowledge and guide future research. We conclude by highlighting specific opportunities for researchers and practitioners to advance research and applications of mindfulness and workplace safety.
Recent advances in quality preservation of postharvest golden needle mushroom (Flammulina velutiper)
Authors: Guo Yuxi , Chen Xuefeng , Gong Pin , Deng Zhenfang , Qi Zhuoya , Wang Ruotong , Long Hui , Wang Jiating , Yao Wenbo , Yang Wenjuan , Chen Fuxin 
Published: April 2023

AbstractThe golden needle mushroom (Flammulina velutiper) is one of the most productive mushrooms in the world. However, F. velutiper experiences continuous quality degradation in terms of changes in color and textural characteristics, loss of moisture, nutrition and flavor, and increased microbial populations due to its high respiratory activity during the postharvest phase. Postharvest preservation techniques, including physical, chemical and biological methods, play a vital role in maintaining postharvest quality and extending the shelf life of mushrooms. Therefore, in this study, the decay process of F. velutiper and the factors affecting its quality were comprehensively reviewed. Additionally, the preservation methods (e.g., low‐temperature storage, packaging, plasma treatment, antimicrobial cleaning and 1‐methylcyclopropene treatment) for F. velutiper used for the last 5 years were compared to provide an outlook on future research directions. Overall, this review aims to provide a reference for developing novel, green and safe preservation techniques for F. velutiper. © 2023 Society of Chemical Industry.
Preparation and Applications of Polydimethylsiloxane‐Based Fluorescent Materials
Authors: Dong Ying , Zhong Hai , Wu Youping , Deng Jianping 
Published: April 2023

AbstractIn the past few years, fluorescent materials have received significant attention due to their fascinating luminescent properties and wide‐ranging applications. Polydimethylsiloxane (PDMS) has also attracted the interest of many researchers due to its remarkable performances. The combination of fluorescence and PDMS will undoubtedly produce abundant advanced multifunctional materials. Although numerous achievements have been made in this field, there is still no review to summarize the relevant research. This review summarizes the state‐of‐the‐art achievements made in PDMS‐based fluorescent materials (PFMs). First, the preparation of PFM is overviewed following a classification according to the fluorescent sources, including organic fluorescent molecules, perovskite, photoluminescent nanomaterials, and metal complexes. Their applications in sensors, fluorescent probes, multifunctional coatings, and anticounterfeiting are then introduced. Finally, the challenges and development trends in the field of PFMs are presented.
MYO1B as a prognostic biomarker and a therapeutic target in Arecoline‐associated oral carcinoma
Authors: Sun Zhen , Guo Xiaopeng , Chen Huarong , Ling Junjun , Zhao Houyu , Chang Aoshuang , Zhuo Xianlu 
Published: April 2023

AbstractBackgroundArecoline, the main component of betel nut, induces malignant transformation of oral cells through complicated unclear mechanisms. Thus, we aimed to screen the key genes involved in Arecoline‐induced oral cancer and further verify their expressions and roles.MethodsThis study included a data‐mining part, a bioinformatics verification part, and an experimental verification one. First, the key gene related to oral cancer induced by Arecoline was screened. Then, the expression and clinical significance of the key gene in head and neck/oral cancer tissues were verified, and its downstream mechanisms of action were explored. Afterwards, the expression and roles of the key gene were verified by experiments at the histological and cytological levels.ResultsMYO1B was identified as the key gene. Overexpression of MYO1B was associated with lymph node metastasis and unfavorable outcomes in oral cancer. MYO1B may be mainly related to metastasis, angiogenesis, hypoxia, and differentiation. A positive correlation between MYO1B and the infiltration of macrophages, B cells, and dendritic cells was presented. MYO1B might have a close relationship with SMAD3, which may be enriched in the Wnt signaling pathway. MYO1B suppression markedly inhibited the proliferation, invasion, and metastasis abilities of both Arecoline‐transformed oral cells and oral cancer cells.ConclusionThis study revealed MYO1B as a key gene in Arecoline‐induced oral tumorigenesis. MYO1B might be a novel prognostic indicator and therapeutic target for oral cancer.
Dual role of sprouty2 as an inhibitor of RAS/ERK‐driven proliferation and a promoter of cancer invasion in KRAS wild‐type colorectal cancer
Authors: Lee Chung‐Ta , Chu Chien‐An , Wang Yu‐Ming , Wang Yi‐Wen , Chen Yi‐Lin , Ho Chung‐Liang , Yeh Yu‐Min , Lin Peng‐Chan , Lin Bo‐Wen , Chen Po‐Chuan , Chen Shang‐Hung , Chan Ren‐Hao , Chang Chen , Chow Nan‐Haw 
Published: April 2023

AbstractSprouty2 (SPRY2) is known to inhibit the RAS/MAPK/ERK pathway, and is a potential study target for cancer. The effect of SPRY2 in colorectal cancer (CRC) and whether it is influenced by KRAS mutation are not known. We manipulated SPRY2 gene expression and used an activating KRAS‐mutant plasmid to determine its effect on CRC cell function in vitro and/or in vivo. We performed SPRY2 immunohistochemical staining in 143 CRC specimens and analyzed the staining results with various clinicopathological characteristics in relation to KRAS mutation status. SPRY2 knockdown in Caco‐2 cells carrying the wild‐type (WT) KRAS gene upregulated phosphorylated ERK (p‐ERK) levels and increased cell proliferation in vitro, but inhibited cell invasion. However, SPRY2 knockdown in SW480 cells (activating KRAS mutant) or Caco‐2 cells transfected with KRAS‐mutant plasmid did not significantly alter p‐ERK levels, cell proliferation, or invasion. The xenografts of SPRY2‐knockdown Caco‐2 cells were larger with less deep muscle invasion than those of control cells. The clinical cohort study revealed a positive association of SPRY2 protein expression with pT status, lymphovascular invasion, and perineural invasion in KRAS‐WT CRCs. However, the associations were not observed in KRAS‐mutant CRCs. Interestingly, high SPRY2 expression was related to shorter cancer‐specific survival in both KRAS‐WT and KRAS‐mutant CRC patients. Our study demonstrated the dual role of SPRY2 as an inhibitor of RAS/ERK‐driven proliferation and as a promoter of cancer invasion in KRAS‐WT CRC. SPRY2 may promote the invasion and progression of KRAS‐WT CRC, and might also enhance KRAS‐mutant CRC progression through pathways other than invasion.