bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of binder concentration in zeolitic ZSM-5/bentonite 3D-printed monoliths manufactured through robocasting for catalytic applications
Authors: Koltsakidis Savvas , Koidi Vasiliki , Lappas Angelos , Heracleous Eleni , Tzetzis Dimitrios 
Published: February 2023

AbstractIn this work, a 3D printing method, robocasting was utilized to manufacture zeolite ZSM-5-based woodpile monolith catalysts of approximately 10-mm diameter, using bentonite clay as binding matrix. The effect of three different binder concentrations, in the 40–60 wt.% range, on the rheological, physicochemical, and mechanical properties was examined. The rheometer measurements showed that the printing pastes have identical shear thinning behavior and demonstrate sufficient storage modulus, irrespective of the binder concentration. The printed monoliths had high BET surface areas and porosity. The results showed that the ZSM-5 crystals retained their porous structure, textural characteristics, and crystalline structure during the additive manufacturing process. Pyridine FTIR measurements demonstrated reduced total acidity and number of Brønsted acid sites in the final specimens due to the dilution with the bentonite powder. However, the acidity reduction was roughly proportional to the binder concentration, signifying that the ZSM-5 crystallites also retain their acidity during the robocasting printing. Finally, the mechanical reliability of the thermally treated monoliths was determined by calculating the Weibull modulus values through linear regression of the Weibull equation. The increase in the binder concentration increased the compression strength by a factor of 4.5 and achieved superior mechanical reliability.Graphical abstract
Complexity-minded antitrust
Authors: Petit Nicolas , Schrepel Thibault 
Published: February 2023

AbstractComplexity science permeates the policy spectrum but not antitrust. This is unfortunate. Complexity science provides a high-resolution screen on the empirical realities of markets. And it enables a rich understanding of competition, beyond the reductionist descriptions of markets and firms proposed by neoclassical models and their contemporary neo-Brandeisian critique. New insights arise from the key teachings of complexity science, like feedback loops and the role of uncertainty. The present article lays down the building blocks of a complexity-minded antitrust method.
When does an additional stage improve welfare in centralized assignment?
Authors: Doğan Battal , Yenmez M. Bumin 
Published: February 2023

AbstractWe study multistage centralized assignment systems to allocate scarce resources based on priorities in the context of school choice. We characterize schools’ capacity-priority profiles under which an additional stage of assignment may improve student welfare when the deferred acceptance algorithm is used at each stage. If the capacity-priority profile is acyclic, then no student prefers any subgame-perfect Nash equilibrium (SPNE) outcome of the 2-stage system to the truthful dominant-strategy equilibrium outcome of the 1-stage system. If the capacity-priority profile is not acyclic, then an SPNE outcome of the 2-stage system may Pareto dominate the truthful dominant-strategy equilibrium outcome of the 1-stage system. If students are restricted to playing truncation strategies, an additional stage unambiguously improves student welfare: no student prefers the truthful dominant-strategy equilibrium outcome of the 1-stage system to any SPNE outcome of the 2-stage system.
Vertebral and pelvic echinococcosis in northwestern China
Authors: Yang Laihong , Tuxunjiang Pahati , Liu Wenya , Guo Hui 
Published: February 2023

Abstract
Purpose
Echinococcosis remains a major economic and severe public health problem in endemic areas. Bone echinococcosis is rare, and the vertebra and pelvis are the most common sites of echinococcosis involving the skeletal. Because of the clinical severe symptoms and high recurrence rate, it brings excellent trouble to patients.

Methods
This study retrospectively analyzed the clinical manifestations, laboratory tests, radiological findings, and treatment of 44 patients with vertebral and pelvic echinococcosis during a period of 16 years (2005–2020).

Results
The mean age was 43 years (25 males, 19 females; 19–68 years). The most common symptom was pain, followed by numbness, weakness, activity limitation, and progressive paraparesis. Enzyme-linked immunosorbent assay test (ELISA) results were positive in 18 cases (75%). There are 24 cases of hydatid infection of the spine, 14 hydatid infection of the pelvis, and six hydatid infection of both vertebra and pelvis. The site of infection was 13 (29.5%) thoracic, five (11.4%) lumbar, four (9.1%) lumbosacral, seven (15.9%) sacral, 19 (43.2%) ilium, seven (15.9%) hip, six (13.6%) ischium, five (11.4%) pubis, and two (4.5%) femur, respectively. The imaging findings were cystic dilatancy, septal, and irregular bone destruction. MRI has a special value in showing the relationship between the surrounding tissues and organs of cystic bone echinococcosis. All patients were followed up for at least one year. The mean follow-up time was 3.6 years.

Conclusions
Even in epidemic areas, the incidence of bone echinococcosis is relatively rare. However, when encountering the vertebral and pelvic destruction, consider bone echinococcosis’s possibility, especially for the herdsmen in endemic regions.
A Systematic Analysis of the Nasal Septum in Crooked Noses and Suggested Treatment Algorithm According to Preservation Rhinoplasty (PR) Principles
Authors: Tremp Mathias , Schneider Jonas , Raghu Ram Badari Narayan , Goksel Abdulkadir , Saban Yves 
Published: February 2023

Abstract
Background
A deviated nose is a common problem among patients for both cosmetic and functional reasons. The correction remains a major challenge for the rhinoplasty surgeon. Unrecognized nasal septal deviations stand as the primary reason for failed rhinoplasty outcomes. There is a paucity of data in the literature about septoplasty classifications and technical details in preservation rhinoplasty (PR) for various crooked noses.

Materials and Methods
The aim of this article is to provide a comprehensive overview of the various septum deviations according to the nasal axis. Moreover, a treatment algorithm is suggested with technical details based on PR principles.

Results
The directions and curvature of the cartilaginous deviation of crooked nose such as C-shaped, reverse C-shaped, straight axis deviations (I-shaped), and S-shaped are described. According to the deviation, a septoplasty classification (Type 1–Type 4) is suggested.

Conclusions
On the basis of septal deviation, different PR techniques are proposed to achieve the desired straight nasal dorsum with an optimal functional outcome. Compared to the classical L-strut concept, the quadrangular cartilage remains preserved in the swinging door technique. The cartilage might be further used in the future for grafting in the hybrid structural/preservation technique if needed, ultimately saving rib cartilage and/or conchal cartilage. Finally, surgery time is reduced, and patient’s morbidity remains minimal.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Use of thrombopoietin receptor agonists in adults with immune thrombocytopenia: a systematic review and Central European expert consensus
Authors: Pulanić Dražen , Bátorová Angelika , Bodó Imre , Červinek Libor , Ionita Ioana , Lissitchkov Toshko , Melikyan Anahit , Podolak-Dawidziak Maria 
Published: February 2023

AbstractThere are currently three thrombopoietin receptor agonists (TPO-RAs) approved in Europe for treating patients with immune thrombocytopenia (ITP): romiplostim (Nplate®), eltrombopag (Revolade®), and avatrombopag (Doptelet®). However, comparative clinical data between these TPO-RAs are limited. Therefore, the purpose of this study was to perform a literature review and seek expert opinion on the relevance and strength of the evidence concerning the use of TPO-RAs in adults with ITP. A systematic search was conducted in PubMed and Embase within the last 10 years and until June 20, 2022. A total of 478 unique articles were retrieved and reviewed for relevance. The expert consensus panel comprised ITP senior hematologists from eight countries across Central Europe. The modified Delphi method, consisting of two survey rounds, a teleconference and email correspondence, was used to reach consensus. Forty articles met the relevancy criteria and are included as supporting evidence, including five meta-analyses analyzing all three European-licensed TPO-RAs and comprising a total of 31 unique randomized controlled trials (RCTs). Consensus was reached on seven statements for the second-line use of TPO-RAs in the management of adult ITP patients. In addition, the expert panel discussed TPO-RA treatment in chronic ITP patients with mild/moderate COVID-19 and ITP patients in the first-line setting but failed to reach consensus. This work will facilitate informed decision-making for healthcare providers treating adult ITP patients with TPO-RAs. However, further studies are needed on the use of TPO-RAs in the first-line setting and specific patient populations.
Psychoanalytisches Standardverfahren und Übertragungsfokussierte Psychotherapie
Authors: Braun Marion , Köpp Werner 
Published: February 2023

ZusammenfassungSeit den siebziger Jahren des 20. Jahrhunderts hat sich das Spektrum seelischer Störungen von der neurotischen Konfliktpathologie hin zu strukturellen Störungen der Persönlichkeit verschoben. Sigmund Freud hielt solche Patientinnen und Patienten zu seiner Zeit für schwer oder gar nicht analysierbar. Die Weiterentwicklung der Psychoanalyse brachte es aber mit sich, dass durch Modifikationen der Standardtechnik auch solche Krankheitsbilder wie narzisstische Persönlichkeitsstörungen oder Borderline-Störungen behandelbar wurden. Die vorliegende Arbeit stellt die Gemeinsamkeiten von psychoanalytischer Standardtechnik und Übertragungsfokussierter Psychotherapie sowie die Unterschiede zwischen beiden Therapieformen dar. Außerdem wird die Notwendigkeit erörtert, die Kandidatinnen und Kandidaten in psychoanalytischer Aus- und Weiterbildung auch mit notwendigen Modifikationen in der analytischen Psychotherapie vertraut zu machen.
STAT1 overexpression triggers aplastic anemia: a pilot study unravelling novel pathogenetic insights in bone marrow failure
Authors: Solimando Antonio Giovanni , Desantis Vanessa , Palumbo Carmen , Marasco Carolina , Pappagallo Fabrizio , Montagnani Monica , Ingravallo Giuseppe , Cicco Sebastiano , Di Paola Rosa , Tabares Paula , Beilhack Andreas , Dammacco Franco , Ria Roberto , Vacca Angelo 
Published: February 2023

AbstractWe identified STAT1 gain of function (GOF) in a 32-year-old female with pallor, weakness, cough, and dyspnea admitted to our Division of Medicine. She had severe oral ulcers (OU), type 1 diabetes (T1DM), and pancytopenia. Bone marrow (BM) biopsy showed the absence of erythroid precursors. Peripheral blood parameters such as neutrophils < 500/mL, reticulocytes < 2%, and BM hypo-cellularity allowed to diagnose severe aplastic anemia. A heterozygous variant (p.520T>C, p.Cys174Arg) of STAT1 was uncovered. Thus, p.Cys174Arg mutation was investigated as potentially responsible for the patient's inborn immunity error and aplastic anemia. Although STAT1 GOF is rare, aplastic anemia is a more common condition; therefore, we explored STAT1 functional role in the pathobiology of BM failure. Interestingly, in a cohort of six patients with idiopathic aplastic anemia, enhanced phospho-STAT1 levels were observed on BM immunostaining. Next, the most remarkable features associated with STAT1 signaling dysregulation were examined: in both pure red cell aplasia and aplastic anemia, CD8+ T cell genetic variants and mutations display enhanced signaling activities related to the JAK-STAT pathway. Inborn errors of immunity may represent a paradigmatic condition to unravel crucial pathobiological mechanisms shared by common pathological conditions. Findings from our case-based approach and the phenotype correspondence to idiopathic aplastic anemia cases prompt further statistically powered prospective studies aiming to elucidate the exact role and theragnostic window for JAK/STAT targeting in this clinical context. Nonetheless, we demonstrate how a comprehensive study of patients with primary immunodeficiencies can lead to pathophysiologic insights and potential therapeutic approaches within a broader spectrum of aplastic anemia cases.
Small extracellular vesicles have distinct CD81 and CD9 tetraspanin expression profiles in plasma from rheumatoid arthritis patients
Authors: Rydland Anne , Heinicke Fatima , Flåm Siri T. , Mjaavatten Maria D. , Lie Benedicte A. 
Published: February 2023

AbstractExtracellular vesicles (EVs) are implicated in the pathogenesis of rheumatoid arthritis (RA) but little is known about the composition of specific small EV (sEV) subpopulations. This study aimed to characterize the CD63, CD81 and CD9 tetraspanin profile in the membrane of single EVs in plasma from treatment naïve RA patients and assess potential discrepancies between methotrexate (MTX) responder groups. EVs isolated from plasma were characterized using transmission electron microscopy, and detection of surface markers (CD63, CD81 and CD9) on single EVs was performed on the ExoView platform. All RA patients (N = 8) were newly diagnosed, treatment naïve, females, ACPA positive and former smokers. The controls (N = 5) were matched for age and gender. After three months of MTX treatment, responders (N = 4) were defined as those with ΔDAS28 > 1.2 and DAS28 ≤ 3.2 post-treatment. The isolated EVs were 50–200 nm in size. The RA patients had a higher proportion of both CD9 and CD81 single positive sEVs compared to healthy controls, while there was a decrease in CD81/CD9 double positive sEVs in patients. Stratification of RA patients into MTX responders and non-responders revealed a distinctly higher proportion of CD81 single positive sEVs in the responder group. The proportion of CD81/CD9 double positive sEVs (anti-CD9 captured) was lower in the non-responders, but increased upon 3 months of MTX treatment. Our exploratory study revealed distinct tetraspanin profiles in RA patients suggesting their implication in RA pathophysiology and MTX treatment response.
Harming by Deceit: Epistemic Malevolence and Organizational Wrongdoing
Authors: Meyer Marco , Choo Chun Wei 
Published: February 2023

AbstractResearch on organizational epistemic vice alleges that some organizations are epistemically malevolent, i.e. they habitually harm others by deceiving them. Yet, there is a lack of empirical research on epistemic malevolence. We connect the discussion of epistemic malevolence to the empirical literature on organizational deception. The existing empirical literature does not pay sufficient attention to the impact of an organization’s ability to control compromising information on its deception strategy. We address this gap by studying eighty high-penalty corporate misconduct cases between 2000 and 2020 in the United States. We find that organizations use two different strategies to deceive: Organizations ‘sow doubt’ when they contest information about them or their impacts that others have access to. By contrast, organizations ‘exploit trust’ when they deceive others by obfuscating, concealing, or falsifying information that they themselves control. While previous research has focused on cases of ‘sowing doubt’, we find that organizations ‘exploit trust’ in the majority of cases that we studied. This has important policy implications because the strategy of ‘exploiting trust’ calls for a different response from regulators and organizations than the strategy of ‘sowing doubt’.
Identifying research practices toward achieving health equity principles within the Cancer Prevention and Control Research Network
Authors: Adsul Prajakta , Islam Jessica , Chebli Perla , Kranick Julie , Nash Sarah , Arem Hannah , Wheeler Stephanie , Lopez-Pentecost Melissa , Foster Victoria , Sharma Rashmi K. , Felder Tisha , Risendal Betsy , Chavarria Enmanuel A. , Kwon Simona , Hirschey Rachel , Trinh-Shevrin Chau 
Published: February 2023

Abstract
Purpose
Although there is national recognition for health equity-oriented research, there is limited guidance for researchers to engage partnerships that promote health equity in cancer research. The Cancer Prevention and Control Research Network’s (CPCRN) Health Equity Work Group developed a toolkit to guide researchers in equitable collaborations.

Methods
The CPCRN’s Health Equity Work Group collectively outlined health and racial equity principles guiding research collaborations with partners that include communities, community-based organizations, implementing partners in the clinical setting including providers and health care organizations, and policy makers. Using a network-wide survey to crowdsource information around ongoing practices, we leveraged and integrated the network’s experience and collaborations.

Results
Data from the survey formed the preliminary basis for the toolkit, with a focus on sharing fiscal resources with partners, training and capacity building, collaborative decision-making, community-driven research agenda setting, and sustainability. The final toolkit provides reflection considerations for researchers and collated exemplary resources, supported by the contemporary research.

Conclusions
The toolkit provides a guide to researchers at all experience levels wanting to engage in equitable research collaborations. Future efforts are underway to evaluate whether and how researchers within and outside CPCRN are able to incorporate these principles in research collaborations.
Association between ECG parameters and late gadolinium enhancement along the course of myocarditis
Authors: Károlyi Mihály , Kolossváry Márton , Weber Lucas , Matziris Ioannis , Polacin Malgorzata , Sokolska Justyna M. , Gotschy Alexander , Alkadhi Hatem , Manka Robert 
Published: February 2023

AbstractPurpose: Numerous electrocardiogram (ECG) abnormalities and late gadolinium enhancement (LGE) in cardiac magnetic resonance imaging (CMR) have been related to poor prognosis in acute myocarditis. We evaluated whether ECG parameters are associated with the distribution and dynamic of LGE along the course of myocarditis. Methods: Fifty-one patients with CMR confirmed acute myocarditis were included who underwent CMR with LGE and 12-lead ECG at baseline and 3-month follow-up at our institution. The association between the presence, regional distribution and change of ECG parameters and LGE was investigated using linear regression analysis. LGE was quantified as visual presence score (VPS) and visual transmurality score (VTS). Results: Among many ECG parameters only > 1 mm ST-elevation (STE) was associated with VPS and VTS at baseline (β = 3.08 [95%CI: 1.75; 4.41], p = < 0.001 and β = 5.40 [95%CI: 1.92; 8.88], p = 0.004; respectively). STE was most frequent in lateral and inferior ECG-leads (48% and 31%) and it was associated with VPS and VTS in these localizations (p < 0.05 all), however no association between anterior-septal STE and LGE could be confirmed. At follow-up the regression of STE was associated with the regression of VPS and VTS in univariate analysis (β=-1.49 [95%CI: -2.41; -0.57], p = 0.003 and β=-4.87 [95%CI: -7.18; -2.56], p = 0.001, respectively), which remained significant for VTS using a multivariate model (β=-2.39 [95%CI: -3.32; -0.47], p = 0.019). Conclusion: Although we demonstrated some promising associations between STE and LGE, the usability of ECG to estimate the territorial involvement and dynamical changes of LGE along the course of myocarditis is generally limited and cardiac magnetic resonance should be considered for this purpose.
Advancing the understanding of forest conservation dynamics through livelihood and landscape change scenarios: a case study in Chiapas, Mexico
Authors: Alfonso-Bécares Diana , Giampietro Mario , Corbera Esteve , Serrano-Tovar Tarik 
Published: February 2023

AbstractForest conversion and conservation in rural settings are linked to both social and biophysical drivers. However, the joint analysis of these drivers presents methodological challenges. To address this problem, we propose a novel methodology to explore the relationship between livelihood heterogeneity and land use change at the community level. It combines the concept of archetype with the accounting scheme of MUlti-Scale Integrated Analysis of Societal and Ecosystem Metabolism to define and quantify the characteristics of livelihood typologies in socioeconomic (time use, financial flows) and ecological terms (land use, agricultural inputs, soil degradation). Conservation trade-offs of potential policies are explored through “what if” scenarios assuming changes in off-farm opportunities, population growth, and conservation/farming subsidies. The approach is tested with a case study of the community of San Isidro, in Chiapas, Mexico. We conclude that the concept of livelihood typologies is useful to inform the debate over conservation prospects in rural environments.
Teachers' perspectives about the content, context, and educational suitability of the GPS cows module for Australian teachers in New South Wales
Authors: Manning Jaime , Cosby Amy , Fogarty Eloise S. , Harreveld Bobby 
Published: February 2023

AbstractTechnology Mandatory (Tech Mandatory) is a compulsory subject for New South Wales (NSW) Stage 4 students and aims to engage students in production and design activities applicable to Agriculture and Food Technologies (AFT), Digital Technologies (DT), Engineered Systems and Material Technologies. The GPS Cows Module, an agricultural education module focused on livestock and Global Positioning System (GPS) livestock data, was co-designed by the NSW Department of Education and CQUniversity Australia. Teachers had previously expressed concern about being able to successfully teach some content of the Tech Mandatory curriculum’s AFT and DT components. Accordingly, the GPS Cows Module focused on livestock production and using digital solutions to address real-world problems. To introduce teachers to the GPS Cows Module and increase Module uptake, several one-day professional learning workshops were run in 2018 and 2019 across NSW, Australia. A post-workshop survey was used to evaluate the GPS Cows Module and the suitability of content related to AFT and DT learning outcomes. Participants agreed or strongly agreed that the Module content would address some of the AFT (92.8% combined) and DT (95.5% combined) outcomes of the curriculum. Over 72% of participants felt their students would find GPS Cows engaging and were excited to teach the Module. However, there were some barriers to implementation including perceptions of student ability, access to technology, teacher confidence and time. Overall, the GPS Cows Module comprises of high-quality content to address some of the AFT and DT outcomes of the Tech Mandatory curriculum. Additionally, it reinforces the importance of authentic data, real-life case studies, and a variety of accompanying resources to effectively implement into a teaching program.