bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data from Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors
Authors: Schroers-Martin Joseph G. , Soo Joanne , Brisou Gabriel , Scherer Florian , Kurtz David M. , Sworder Brian J. , Khodadoust Michael S. , Jin Michael C. , Bru Agnès , Liu Chih Long , Stehr Henning , Vineis Paolo , Natkunam Yasodha , Teras Lauren R. , Song Joo Y. , Nadel Bertrand , Diehn Maximilian , Roulland Sandrine , Alizadeh Ash A. 
Published: May 2023

<div>Abstract<p>Follicular lymphomas (FL) are characterized by <i>BCL2</i> translocations, often detectable in blood years before FL diagnosis, but also observed in aging healthy individuals, suggesting additional lesions are required for lymphomagenesis. We directly characterized early cooperating mutations by ultradeep sequencing of prediagnostic blood and tissue specimens from 48 subjects who ultimately developed FL. Strikingly, <i>CREBBP</i> lysine acetyltransferase (KAT) domain mutations were the most commonly observed precursor lesions, and largely distinguished patients developing FL (14/48, 29%) from healthy adults with or without detected <i>BCL2</i> rearrangements (0/13, <i>P</i> = 0.03 and 0/20, <i>P</i> = 0.007, respectively). <i>CREBBP</i> variants were detectable a median of 5.8 years before FL diagnosis, were clonally selected in FL tumors, and appeared restricted to the committed B-cell lineage. These results suggest that mutations affecting the <i>CREBBP</i> KAT domain are common lesions in FL cancer precursor cells (CPC), with the potential for discriminating subjects at risk of developing FL or monitoring residual disease.</p>Significance:<p>Our study provides direct evidence for recurrent genetic aberrations preceding FL diagnosis, revealing the combination of <i>BCL2</i> translocation with <i>CREBBP</i> KAT domain mutations as characteristic committed lesions of FL CPCs. Such prediagnostic mutations are detectable years before clinical diagnosis and may help discriminate individuals at risk for lymphoma development.</p></div>
Disability-Adjusted Life Years Due to Pediatric Out-of-Hospital Cardiac Arrest in the United States: A CARES Surveillance Group Study
Authors: Coute Ryan A. , Nathanson Brian H. , DeMasi Stephanie , Mader Timothy J. , Kurz Michael C. ,   for the CARES Surveillance Group*
Published: May 2023

Background:
Disability-adjusted life years (DALY) are a common public health metric used to estimate disease burden. The DALY due to pediatric out-of-hospital cardiac arrest (OHCA) in the United States is unknown. We aimed to estimate pediatric OHCA DALY and to compare it with the other leading causes of pediatric death and disability in the United States.

Methods:
We conducted a retrospective observational analysis of the national Cardiac Arrest Registry to Enhance Survival database. DALY were calculated as the sum of years of life lost and years lived with disability. Years of life lost were calculated using all pediatric (age <18 years) nontraumatic OHCA from the Cardiac Arrest Registry to Enhance Survival from 2016 to 2020. Disability weights based on cerebral performance category scores, an outcome measure of neurologic function, were used to estimate years lived with disability . Data were reported as total, mean, and rate per 100 000 individuals, and were compared with the leading causes of pediatric DALY in the United States published by the Global Burden of Disease study for 2019.

Results:
Totally 11 177 OHCA met the study inclusion criteria. A modest increase in total OHCA DALY in the United States was observed from 407 500 (years of life lost = 407 435 and years lived with disability =65) in 2016 to 415 113 (years of life lost = 415 055 and years lived with disability =58) in 2020. The DALY rate increased from 553.3 per 100 000 individuals in 2016 to 568.3 per 100 000 individuals in 2020. For 2019, OHCA was the 10th leading cause of pediatric DALY lost behind neonatal disorders, injuries, mental disorders, premature birth, musculoskeletal disorders, congenital birth defects, skin diseases, chronic respiratory diseases, and asthma.

Conclusions:
Nontraumatic OHCA is one of the top 10 leading causes of annual pediatric DALY lost in the United States
Racial Differences in Quality of Life in Patients With Heart Failure Treated With Sodium–Glucose Cotransporter 2 Inhibitors: A Patient-Level Meta-Analysis of the CHIEF-HF, DEFINE-HF, and PRESERVED-HF Trials
Authors: Gupta Kashvi , Spertus John A. , Birmingham Mary , Gosch Kensey L. , Husain Mansoor , Kitzman Dalane W. , Pitt Bertram , Shah Sanjiv J. , Januzzi James L. , Lingvay Ildiko , Butler Javed , Kosiborod Mikhail , Lanfear David E. 
Published: May 2023

BACKGROUND:
Health status outcomes, including symptoms, function, and quality of life, are worse for Black compared with White patients with heart failure. Sodium–glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular mortality and improve health status in patients with heart failure, but whether the health status benefit of SGLT2is is similar across races is not established. The objective of this study was to compare the treatment effect of SGLT2is (versus placebo) on health status for Black compared with White patients with heart failure.

METHODS:
We combined patient-level data from 3 randomized clinical trials of SGLT2is: DEFINE-HF (Dapagliflozin Effect on Symptoms and Biomarkers in Patients With Heart Failure; n=263), PRESERVED-HF (Dapagliflozin in Preserved Ejection Fraction Heart Failure; n=324), and CHIEF-HF (A Study on Impact of Canagliflozin on Health Status, Quality of Life, and Functional Status in Heart Failure; n=448). These 3 United States–based trials enrolled a substantial proportion of Black patients, and each used the Kansas City Cardiomyopathy Questionnaire (KCCQ) to measure health status at baseline and after 12 weeks of treatment. Among 1035 total participants, selecting self-identified Black and White patients with complete information yielded a final analytic cohort of 935 patients. The primary endpoint was KCCQ Clinical Summary score. Twelve-week change in KCCQ with SGLT2is versus placebo was compared between Black and White patients by testing the interaction between race and treatment using multivariable linear regression models adjusted for trial, baseline KCCQ (as a restricted cubic spline), race, and treatment. The data that support the findings of this study are available from the corresponding author upon reasonable request.

RESULTS:

Among 935 participants, 236 (25%) self-identified as Black, and 469 (50.2%) were treated with an SGLT2i. Treatment with an SGLT2i, compared with placebo, resulted in KCCQ Clinical Summary score improvements at 12 weeks of +4.0 points (95% CI, 1.7–6.3;
P
=0.0007) in White patients and +4.7 points (95% CI, 0.7–8.7;
P
=0.02) in Black patients, with no significant interaction by race and treatment (
P
=0.76). Other KCCQ scales showed similar results.

CONCLUSIONS:
Treatment with an SGLT2i resulted in consistent and significant improvements in health status for both Black and White patients with heart failure.
Morphological and molecular characterisation of Mulveyellus aizawlensis sp. n. (Nematoda: Iotonchinae) from Aizawl, Mizoram, India
Authors: Singh Samandram Sushilkumar , Singh Phougeishangbam Rolish , Singh Sorokhaibam Mexico , Singh Mayanglambam Ojit Kumar , Meitei Naorem Mohilal 
Published: May 2023

Summary
Analysis of a soil sample from Aizawl district of Mizoram, India, led to the discovery of Mulveyellus aizawlensis sp. n. The new species is presented with female morphological data and molecular data of the D2-D3 expansion segment of 28S and 18S of rDNA, and phylogenetic analysis data based on these sequences. Mulveyellus aizawlensis sp. n. is morphologically characterised by a ventrally arcuate female body, presence of minute transverse striations on cuticle, a barrel-shaped buccal cavity, a dorsal tooth at anterior half of the buccal cavity, toothless subventral wall, distinct cup-shaped amphids located at the level of the dorsal tooth, a tuberculate pharyngo-intestinal junction, bean-shaped pars refrigens vaginae, a didelphic-amphidelphic reproductive system, a conoid ventrally-arcuate tail, and absence of caudal glands and spinneret. This study presents molecular data of the genus Mulveyellus for the first time and revealed a close phylogenetic relationship of this genus with Prionchulus.
The Afterlife of Eurasian Long-distance Correspondence: From Jesuit Epistle to European Print
Authors: Givon Yuval 
Published: May 2023

Abstract
This article carefully examines the long trajectory of a seventeenth-century letter in order to contribute to scholarship on the circulation and reproduction of information from Asia in European print in the early modern period. The letter was written by the Jesuit missionary and traveler Johann Grueber (1623–1680) to his colleague in Rome, the renowned scholar Athanasius Kircher (1602–1680). Spanning over a century of circulation and moving between the original context of Chinese missionary work in which the letter was composed and the scholarly networks throughout which it later circulated in Europe, the article elucidates the spread and evolution of Eurasian long-distance information in the early modern period, particularly between manuscript and print. It also examines how writers and publishers in Europe made selective use of the information within those manuscripts in their printed works, from the seventeenth century into the era of Enlightenment. The article thereby offers insights into questions of composition, authorship, reproduction, and distribution in the making of long-distance Eurasian information exchanges during the early modern period.
“A Bank of Trust”: Legal Practices of Ottoman Finance Between Empires
Authors: Nye Ellen M. 
Published: May 2023

Abstract
How agreements were maintained and enforced beyond state-backed systems is among the least understood aspects of Ottoman legal history. This article reveals how merchants’ engagement with Ottoman state finance intertwined private and state-backed legal practices through a letter-book written entirely in Ottoman Turkish belonging to a seventeenth-century English merchant, Peter Whitcomb, who provided financial services to Ottoman officials across the empire. As a rare example of surviving early modern mercantile correspondence in Ottoman Turkish, Whitcomb’s letters to distant officials expose Ottoman financial epistolary culture and a wide range of alternative methods of dispute resolution. By combining these letters with court records, this article shows how Ottoman finance’s layers of devolved authority themselves relied on a range of legal practices that encompassed a language of reciprocity and reputation, established Ottoman documentary forms, intercessions on an individual’s behalf, appeals to elites, petitions to the grand vizier, and appearances in Ottoman sharīʿa courts. The capacity of Ottoman state finance to incorporate a foreigner like Whitcomb into its fiscal apparatus through this breadth of legal practices further suggests that we should revisit domestic narratives of competitive early modern state formation to include inter-imperial actors.
Not Afraid of My Sponsor
Authors: Cooley Claire 
Published: May 2023

Abstract
This article considers the role of media infrastructures in the U.A.E. racializing the South Asian migrant workers making, maintaining and interacting with them. Employing a sonic methodology, I historicize these infrastructures and legacies of racialization by considering the fiber optic cables carrying telecommunications in the region and their positioning along colonial trade routes, telegraph networks and other pathways connecting British colonies. These cables have more recently facilitated U.S. military interests and the growing importance of the U.A.E. as a hub for logistics. After analyzing sound and sound-related metaphors concerning the U.A.E.’s increasing power as a media hub in the region, facilitated by its media infrastructures, I argue that we can ‘hear’ how media infrastructures exploit and racialize labor but also enable a space for laborers to come together and absorb the pressure of neoliberal work.
Bronze Fish
Authors: Hudson Mark , Muñoz Fernández Irene M. 
Published: May 2023

Abstract
The Bronze Age was a time of pivotal economic change when new long-distance trading networks became associated with a macro-regional division of labour and decentralised political complexity. These developments occurred against the background of a shifting mosaic of subsistence patterns, which included the east-west exchange of crops across Eurasia and (in some areas) greater use of secondary products. As Bronze Age economies became more specialised and diverse, it might be assumed that there was also an increased emphasis on the procurement and trade of fish and other marine resources. However, archaeological analyses of such resources are limited in contrast to land-based subsistence patterns and many questions remain. This essay aims to build a broad interpretive framework for analysing the role of marine resources in the Bronze Age. Our provisional results find that an increased emphasis on specialist systems of agropastoralism reduced the use of marine resources in many parts of Eurasia during this period. However, evidence from Japan and the eastern Mediterranean suggests that, at least in some regions, marine resources became commodities traded over long-distances by the late Bronze Age, though this requires further quantification. Island Southeast Asia displays a different pattern from other regions considered here in a greater continuity of marine resource use from the Neolithic into the historic era, perhaps due to a lower reliance on agropastoralism.
Outcomes Following Below Knee Arterial Trauma
Authors: Croman Millicent , Lamberton Tessa , Covington Audrey , Keeley Jessica A 
Published: May 2023

Introduction Lower extremity vascular injuries have significant implications for trauma patients with regards to morbidity from limb loss. There is limited evidence on outcomes for patients with injuries to tibial arteries. Our study focuses on defining outcomes of traumatic vascular injury to vessels below the knee. Methods A retrospective review using ICD-9 and 10 codes of all patients with below knee vascular injuries was performed at a Level 1 trauma center from November 2014 to June 2022. Interventions, outcomes, and complications were assessed. Results Seventy-six patients were identified fitting inclusion criteria. The mean age was 35.3 +/− 15.2 years and 67 (88%) patients were male. Thirty-nine suffered penetrating trauma, 37 suffered blunt trauma. The most injured artery was posterior tibial artery (40%) followed by anterior tibial artery (36%). Injuries included 51 transections, 22 occlusions and 4 pseudoaneurysms. Forty-five (59%) patients underwent operative intervention. Thirty (67%) operations were performed by trauma surgery. Arterial ligation was performed in 30 cases (67%), arterial bypass in 12 (27%), and 2 (4%) primary amputations. Vascular surgery performed all bypasses. Overall amputation rate was 8% ( n = 6) with 3 for mangled extremity and 3 due to failed bypass graft. All amputations were associated with open fracture and amputations for failed bypass had multiple arterial injuries. Conclusion The management of below knee vascular trauma requires a multidisciplinary approach. Patients requiring reconstruction are more likely to have multiple vessel injuries and may have significant risk of graft failure. These patients as well as those with extensive soft tissue injury and/or multi-vessel injuries are at increased risk for amputation
Curcumin nanocapsules effect in apoptotic processes, gene expression, and cell cycle on Hep-G2 cell lines
Authors: Moawad Mahmoud , Nasr Ghada M , Osman Afaf S , Shaker Emad S 
Published: May 2023

Objectives Curcumin has antioxidant and antiproliferative properties, and its therapeutic effect must be considered. Nanocurcumin capsules showed a potential increase against in vitro biological cancer. This study sought to determine how curcumin nanoparticles and nanocapsules affected the expression of p53, Bcl-2, Bax, and Bax in a liver cancer cell line (Hep-G2). Mechanisms of apoptosis were also examined in this cell line. Methods This study used quantitative real-time polymerase chain reaction (qRT-PCR) to analyze the p53, Bcl-2, Bax, and Caspase-3 gene pathways and to evaluate the molecular mechanisms responsible for the efficacy of curcumin nanoparticles (CNPs) and curcumin nanocapsules (CNCs) against liver cell lines. Flow cytometry was used to check for signs of apoptosis and the cell cycle. Results Curcumin nanocapsules produced by the ball milling process at 90 min significantly boosted the populations of apoptotic cells in a dose- and time-dependent manner. The mRNA expression analysis revealed that the proapoptotic Bax, Caspase-3, and the tumor suppressor gene p53 were upregulated throughout the process started by curcumin nanocapsules and decreased in the Bcl-2/Bax ratio . Conclusion This research provides a fresh understanding of the molecular mechanisms behind the liver cancer-fighting abilities of curcumin nanoparticles. Curcumin nanocapsules produced through a unique mechanical technique can be used as an anticancer agent.
Immunological disease activity parameters at conception are risk factors for preterm birth and low birth weight in patients with systemic lupus erythematosus
Authors: Shimada Hiromi , Wakiya Risa , Kameda Tomohiro , Nakashima Shusaku , Miyagi Taichi , Sugihara Koichi , Ushio Yusuke , Mino Rina , Mizusaki Mao , Chujo Kanako , Kanenishi Kenji , Kadowaki Norimitsu , Dobashi Hiroaki 
Published: May 2023

Objective This study aimed to identify which disease activity parameters may be risk factors for preterm birth (PB) and low birth weight (LBW) in patients with systemic lupus erythematosus (SLE). We also analyzed the extent to which these parameters affected PB and LBW. Methods We collected the SLE Disease Activity Index (SLEDAI), the rate of lupus low disease activity state (LLDAS) attainment, complement levels, and the titer of anti-double stranded DNA (dsDNA) antibody as disease activity parameters. We retrospectively analyzed the associations of these parameters with PB and LBW. Results Sixty pregnancies were included in this study. C3 levels and anti-dsDNA antibody titers at conception were strongly associated with PB ( p = 0.03 and p = 0.01, respectively), whereas C3 and CH50 levels were associated with LBW ( p = 0.02 and p = 0.03, respectively). A logistic regression analysis showed that the cutoff values of C3 and anti-dsDNA antibody for PB were 62.0 mg/dl and 5.4 IU/ml, respectively. The cutoff values of C3 and CH50 for LBW were 87.0 mg/dl and 41.8 U/ml, respectively. The risk of PB or LBW was increased when divided by the cutoff value, and the combination of these cutoff values showed a significantly higher risk of PB and LBW ( p = 0.01 and p < 0.01, respectively). Conclusions PB and LBW are strongly associated with disease activity parameters in patients with SLE. Therefore, strictly monitoring and controlling these disease activity parameters, with or without clinical manifestation, is important for women who want to become mothers.
A Mapping Review of Netnography in Nursing
Authors: Salzmann-Erikson Martin , Eriksson Henrik 
Published: May 2023

People use the Web to seek health-related information and to discuss health issues with peers. Netnography, a qualitative research methodology, has gained the attention of researchers interested in people’s health and health issues. However, no previous reviews have accounted for how netnography is used in nursing research. The purpose of this mapping review was to generate a map of netnographic research in nursing. The search was conducted in PubMed, Academic Search Elite, the Cumulative Index to Nursing and Allied Health Literature, Medline, PsycINFO, Scopus, and Web of Science. Data were extracted from 53 original articles. The results show an increasing trend in published netnographies over time; 34% of the total sample was published in 2021. Of the total, 28% originated from Sweden, and 81% had used a covert approach. In studies in which the researchers used more participatory designs, the time spent on online forums ranged between 4 weeks and 20 months. Informed consent is found to be an issue in netnographic studies. We discuss the fact that nursing researchers have used netnography to address a wide range of research topics of concern and interest, from self-care support in an online forum for older adults to nursing students’ perspectives on effective pedagogy. In line with the digital transformation in society in general, we discuss the fact that netnography as a research methodology offers great opportunities for nurse researchers to monitor new spaces and places that presuppose online methodological knowledge.
District and School Leaders’ Efforts Concerning the Public Gender Transition of a High School Teacher
Authors: Wright Tiffany , Brooks Sarah 
Published: May 2023

Purpose This case study examined the efforts of district and school level leaders related to the public gender transition of one high school teacher over a 2-year period. We employed Theoharis’ (2007) conceptualization of social justice education leadership to guide our analysis. Research Methods This qualitative inquiry drew from in-depth, semi-structured interviews with the superintendent, transgender teacher, high school principal and relevant teacher union leaders. Related documents were also collected to triangulate the data sources. Data analysis involved open coding to identify themes and significant features of participants’ actions and experiences. Findings The findings are presented in the form of a chronological narrative about district and school leaders’ actions as one teacher underwent a public gender transition. Following this narrative, we explore three critical characteristics of the educational leaders’ actions: Collaborative communication, intentionality and anticipation, and framing. Implications This study addresses a significant gap in the literature concerning how educational leaders might work to create safe school environments for LGBTQ educators. While the efforts made by district and school level leaders in this case represent important steps toward creating safe environments for transgender educators, additional professional development and policy making are critical actions that could build on the efforts detailed in this case.