bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review on the Extant of Tanzania e-Government Services for Economic Development
Authors: Mwilongo Kardo , Kachota Beth 
Published: March 2023

Abstract
The current paper investigates the extant of Tanzania e-government services for economic development by focusing at the recent literature through systematic review of literature. The main objective is to look at how researchers are studying e-government services toward achieving the Tanzania national development goals and economic growth, what are the current issues investigated and what is going to be the direction of the topic globally. The findings reveal that the Tanzania e-government services are performed at the ministerial, departmental, agencies and institutions through various information systems including the webpages and social networks. Various levels of e-government implementation and performance are being deployed for public services and economic development. However, a number of factors related to infrastructures, technology, human capital, policy, practitioners and partnerships among others were identified to hinder the delivery of e-government services to the public and brought adverse effect on e-government performance for economic development.
Timings of treatments determine the effectiveness of insecticides in controlling the cotton pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)
Authors: Busnoor Abhishek V , Wadaskar RM , Fand Babasaheb B , Tambe VJ , Pillai T , Mahule DJ , Nagrare VS , Prasad YG 
Published: March 2023

Abstract
The cryptic nature enabled reduced vulnerability to insecticidal control of the pink bollworm Pectinophora gossypiella (Saunders), a serious threat to transgenic cotton cultivation due to development of resistance against Bacillus thuringiensis (Bt) toxins necessitated determining the critical timings of spray applications on the effectiveness of its control. This study assessed the influence of egg age and location of larvae as exposed vs. burrowed inside the bolls on insecticide control efficacy.
The results revealed significant decrease in ovicidal activity of test insecticides with the increase in age of eggs from one day old to three days old (paired t-test, P values <0.05). The larvae directly exposed to the insecticide residues on boll rind were more susceptible (>80% mortality) than that of larvae exposed after they burrowed inside the bolls (<49% mortality). The inhibitory effects of test insecticides on the developmental biology were more pronounced in the experiment on pre-larval release insecticide treatment compared to insecticide treatment given post-larval release and entry inside the bolls. Very low fecundity (< 5 eggs/female), higher effective deterrency (>96%) and higher avoidance index (>0.93) revealed oviposition deterrent activity of test insecticides. The test insecticides also exhibited significant adulticide action on PBW moths. The study has generated information crucial to the development of effective management strategy for cotton pink bollworm.
Formation of Market Foundations of Health Care Organization in Ukraine (Commercial Legal Aspect)
Authors: Zadykhaylo Dmitry , Savchenko Anna 
Published: March 2023

In the article were analyzed the state and prospects of further medical reform in Ukraine. The authors set themselves the goal of conducting a study of the essence of health care reform, and during this process advantages and disadvantages of implemented changes in this area were characterized. The importance of this study lies in the fact that human health and life are recognized at the constitutional level as the highest price, and therefore their protection requires special attention from the state. Promoting the development of health care system improve the quality of life of the population, which in the future will have a positive effect on the economic development of the country. Four main directions of the reform were developed in the work, such as improving the quality of medical services, optimizing the financing of the health care system, improving the management system, and changes in the pharmaceutical sector. An important achievement of the reform is the introduction of the medical services market, which has its own specific features and base on the principle of free competition and financial transparency. The article focuses on the legal regulation of public relations in the field of health care. Legislative provision of this is considered from the point of view of creating a competitive market for medical services, which is opposed to the administrative model of ensuring citizens' health care. The institutional nature of the organization of such market with relevant entities providing services competing with each other is emphasized; medical service in its commodity-value aspect; introduction of the principle of consumer choice of medical service and the entity that provides it; creation of a special state agency that pays the cost of the provided medical service to the relevant subject of medical activity for the benefit of the beneficiary-consumer, who chose this particular subject. Accordingly, the driving force of the market is recognized the actual medical economic activity. Taking into account the above, the article, based on the analysis of the relevant legal acts, concludes that relations in the field of health care have been transformed in the direction of the economic and legal nature of their regulation. This is evidenced by the use of stable constructions of economic law, namely: economic activity; non-commercial management; communal non-commercial enterprise; state regulation of economic activity; subject of organizational and economic powers, etc. The continuation of scientific researches on this issue will contribute to the further development of the national health sector, including by improving the public management of this component of the national economy.
Quantitative analysis on the oil content of oilfield wastewater based on a convolutional neural network model and ultraviolet transmission spectroscopy
Authors: Wang Qiushi , Li Haolin , Zhao Haiqian , Zhang Xiaoxue , Arıcı Müslüm , Li Huaizhi 
Published: March 2023

Abstract
Oil content (OC) is one of the important evaluation indicators in oilfield wastewater (OW) treatment. The purpose of this study is to realize online real-time detection of OC in OW by combining ultraviolet spectrophotometry with the convolutional neural network (CNN). In this paper, 80 groups of OW transmission data were measured for model establishment. Three CNN models with different structures are established to generalize the super parametric optimization process of the model. Furthermore, as a common method used in spectroscopy, the synergy interval partial least squares (siPLS) model is built in order to compare its accuracy with the CNN model. The results indicated the CNN model has a better performance than siPLS, in which the CNN model numbered Model 3 has the lowest root mean square error (MSE) of prediction (RMSEP) of 1.606 mg/L. As a consequence, the CNN model can be used in the monitoring of OW. This article will guide a rapid analysis of the OC of OW.
Traditional Chinese Medicine as the Preventive and Therapeutic
Remedy for COVID-19
Authors: Gasmi Amin , Tippairote Torsak , Mujawdiya Pavan Kumar , Menzel Alain , Lysiuk Roman , Shanaida Mariia , Lenchyk Larysa , Peana Massimiliano , Bjørklund Geir 
Published: March 2023

Abstract:
The coronavirus disease 2019 (COVID-19) pandemic still has tremendous impacts
on the global socio-economy and quality of living. The traditional Chinese
Medicines (TCM) approach showed encouraging results during previous outbreaks of Severe
Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) and the Middle East
Respiratory Syndrome Coronavirus (MERS-CoV). With limited treatment availability,
TCM herbs and formulations could be useful to reduce COVID-19 symptoms and potential
sources for discovering novel therapeutic targets. We reviewed 12 TCM herbs and
formulations recommended for COVID-19 management by the National Health Commission
and as National Administration of Traditional Chinese Medicine of the People's Republic
of China. This article explored the Chinese national authorities' guidelines from
2003 to 2020, the scientific data in public databases for the recommended TCM remedies,
and their potential mechanistic actions in COVID-19 management. Several TCM
herbs and formulations could potentially benefit COVID-19 management. The recommended
TCM oral preparations list includes Huoxiang zhengqi, Jinhua Qinggan, Lianhua
Qingwen, and Shufeng jiedu; the recommended injection preparations comprise
Xiyanping Xuebijing, Re-Du-Ning, Tanreqing, Xingnaojing, Shenfu, Shengmai, and Shenmai.
TCM remedies are viable options for symptom alleviation and management of
COVID-19. The current SARS-CoV-2 pandemic presents an opportunity to find novel
therapeutic targets from TCM-active ingredients. Despite the recommendations in Chinese
National guidelines, these remedies warrant further assessments in well-designed
clinical trials to ascertain their efficacy in the treatment of COVID-19.
Selective Cellular Uptake and Cytotoxicity of Curcumin-encapsulated SPC and
HSPC Liposome Nanoparticles on Human Bladder Cancer Cells
Authors: Gholami Leila , Momtazi-Borojeni Amir Abbas , Malaekeh-Nikouei Bizhan , Nikfar Banafsheh , Amanolahi Farjad , Mohammadi Ali , Kazemi Oskuee Reza 
Published: March 2023

Background:
Curcumin is a main bioactive constituent of turmeric (Curcuma longa L.) with pleiotropic
health beneficial effects. However, poor bioavailability is the major barrier to the efficient pharmacological
effects of curcumin in humans.

Aims:
The present study aimed to develop liposome formulations based on soybean phosphatidylcholine (SPC)
and hydrogenated SPC (HSPC) to enhance the bioavailability of curcumin in bladder cancer cells.

Methods:
Curcumin was encapsulated in HSPC and SPC liposome nanoparticles using the solvent evaporation
method. Physical properties, encapsulation efficiency (%), stability, and in vitro drug release of the prepared
liposome formulations have been evaluated. The cellular uptake and cytotoxicity of curcumin-encapsulated
nanoliposomes on bladder carcinoma HTB9 cell line and normal fibroblast L929 cell line were studied. DNA
fragmentation, apoptosis, and genotoxicity assessments have been carried out to determine the molecular mechanisms
underlying the cytotoxic effects of liposomal curcumin formulations on bladder cancer cells.

Results:
The results indicated that curcumin could be efficiently encapsulated in the HSPC and SPC liposome
formulations. The liposomal curcumin formulations have shown shelf-life stability for 14 weeks at 4°C. The
accelerated stability testing showed that curcumin encapsulated in nanoliposomes was significantly (p < 0.001)
more stable than free curcumin at various pH degrees ranging from alkaline to acidic pH. The in vitro drug release
study showed curcumin to be sustainably released from the liposome nanoparticles. Of note, SPC and
HSPC nanoliposome formulations significantly increased the cellular uptake and cytotoxicity of curcumin on
bladder cancer HTB9 cells. Mechanistically, liposomal curcumin was found to exert a selective inhibitory effect
on the viability of cancer cells by inducing apoptosis and DNA damage.

Conclusion:
In conclusion, SPC and HSPC liposome nanoparticles can significantly increase the stability and
bioavailability of curcumin, which are important for improving its pharmacological effect.
The Potential of Lipid Droplet-associated Genes as Diagnostic and Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma
Authors: Bai Yu-Ting , Wang Xin , He Ming-Jing , Xie Ji-Rong , Chen Xiao-Jie , Zhou Gang 
Published: March 2023

Objective:
The role of lipid droplets (LDs) and lipid droplet-associated genes (LD-AGs)
remains unclear in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate
LDs in HNSCC and identify LD-AGs essential for the diagnosis and prognosis of HNSCC
patients.

Methods:
The LDs in the HNSCC and normal cell lines were stained with oil red O. Bioinformatic
analysis was used to find LD-AGs in HNSCC that had diagnostic and prognostic significance.

Results:
LDs accumulation was increased in HNSCC cell lines compared with normal cell lines
(P<0.05). Fifty-three differentially expressed genes, including 34 upregulated and 19 downregulated,
were found in HNSCC based on the TCGA platform (P<0.05). Then, 53 genes were proved to
be functionally enriched in lipid metabolism and LDs. Among them, with an AUC value > 0.7, 34
genes demonstrated a high predictive power. Six genes (AUP1, CAV1, CAV2, CAVIN1, HILPDA, and
SQLE) out of 34 diagnostic genes were linked to overall survival in patients with HNSCC (P<0.05).
The significant prognostic factors AUP1, CAV1, CAV2, and SQLE were further identified using the
univariate and multivariate cox proportional hazard models (P<0.05). The protein expression of
CAV2 and SQLE was significantly increased in the HNSCC tissue compared to normal tissues
(P<0.05). Finally, the knockdown of the four LD-AGs decreased LDs accumulation, respectively.

Conclusions:
Increased LDs accumulation was a hallmark of HNSCC, and AUP1, CAV1, CAV2,
and SQLE were discovered as differentially expressed LD-AGs with diagnostic and prognostic
potential in HNSCC.
Heterogeneity of Red Blood Cell Deformability Caused by Lipopolysaccharide
based on a Microfluidic Chip
Authors: Chen Yue , Liu Zhen , Shao Huaze , Xu Jun , Li Jincheng , Chen Haoyi , Zhou Chunqiong , Liu Lihong 
Published: March 2023

Introduction:
Alterations in red blood cell deformability (RBC-df) provide important
information for the diagnosis of various diseases.

Aim:
We evaluated individual differences of lipopolysaccharide (LPS)-induced oxidative damage
of RBC-df and analyzed the correlation between RBC-df and biochemical parameters.

Methods:
A microfluidic chip was developed to detect inter-individual variability of different
concentrations of LPS-induced oxidative damage of RBC-df in 9 healthy volunteers. The relationships
between various biochemical indicators (Na+-K+-ATPase activity, lipid peroxide (LPO) content,
glutathione peroxidase (GSH-PX) activity, catalase (CAT) activity, superoxide dismutase
(SOD) activity, adenosine triphosphate (ATP) content, and hemoglobin (HB) content) and RBCsdf
were investigated.

Results:
The obvious inter-individual variability of LPS-induced oxidative damage of RBC-df was
revealed. The Na+-K+-ATPase activity, LPO content, GSH-PX activity, and CAT activity of RBCs
showed significant correlations with RBC-df (P < 0.05).

Conclusion:
Oxidative damage and energy metabolism are the critical factors of RBC-df impairment
induced by LPS, and the individual dependence on RBC-df is an important indicator for the
treatment of infection-associated sepsis since antibiotics can kill pathogenic bacteria, which results
in the release of LPS from the cell wall.
Bromelain: An Enzyme Expanding its Horizon from Food to Pharmaceutical
Industry
Authors: Sharma Gauresh , Vimal Archana 
Published: March 2023

Abstract:
Bromelain is a protein digestive enzyme obtained from the extract of pineapple (steam,
fruit, and leaves). It is a cocktail of several thiol endopeptidases and other components like peroxidase,
cellulase, phosphatase, and several protease inhibitors. It is a glycoprotein with an oligosaccharide
in its molecular structure that contains xylose, fucose, mannose, and N-acetyl glucosamine.
Many approaches have been used in the extraction and purification of bromelain like filtration,
membrane filtration, INT filtration, precipitation, aqueous two-phase system, ion-exchange
chromatography, etc. This enzyme is widely used in the food industry for meat tenderization, baking,
cheese processing, seafood processing, etc. However, this enzyme also expands its applicability
in the food industry. It is reported to have the potential for the treatment of bronchitis, surgical
trauma, sinusitis, etc. The in vitro and in vivo studies showed that it possesses fibrinolytic, antiinflammatory,
antithrombotic, anti-edematous activity, etc. The human body absorbed bromelain
without any side effects or reduction in its activity. However, in some cases, it shows side effects
in those patients who are allergic to pineapple. To minimize such adverse effects bromelain is
immobilized inside the nanoparticles. This paper gives an overview of the production, purification,
and application of this industrially important enzyme in the food and pharmaceutical industry. It
also discusses the various immobilization strategies used to enhance its efficiency.
The Clinical Safety and Efficacy of Targeted PD-L1 Therapy with Durvalumab
in Solid Tumors
Authors: Chen Mengmeng , Jiang Jian , Chen Junyu , Wang Mengqi , Lu Yaci , Liu Lei , Zhao Lijing , Wang Lisheng 
Published: March 2023

Abstract:
Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) checkpoint
inhibitors have been on the front line of clinical revolution in which, the targeted PD-L1 therapy
has obtained some success in patients with solid tumors. A large number of clinical trials revealed
that both monotherapy and combination therapy of PD-L1 antibody significantly suppress
some tumor growth and promote the survival of patients. At present, anti-PD-L1 treatment has
been used as a portion of standard treatment for lung cancer, breast cancer, head and neck squamous
cell carcinoma, and urothelial carcinoma. Although much evidence has demonstrated that
PD-L1 antibody is safe in most patients, there are still some adverse reactions, such as pneumonitis,
hepatitis, colitis, neurologic events and myocarditis. In this review, the clinical information, including
the efficacy and safety of durvalumab in solid tumors, was enumerated and summarized at
this stage to grasp the current application of targeted PD-L1 therapy and provide guidance for clinical
application.
Roadmap to Pyruvate Kinase M2 Modulation - A Computational
Chronicle
Authors: Shard Amit , Kapoor Saumya , Chatterjee Deep Rohan , Chowdhury Moumita Ghosh , Das Rudradip 
Published: March 2023

Abstract:
Pyruvate kinase M2 (PKM2) has surfaced as a potential target for anti-cancer therapy.
PKM2 is known to be overexpressed in the tumor cells and is a critical metabolic conduit in supplying
the augmented bioenergetic demands of the recalcitrant cancer cells. The presence of PKM2 in
structurally diverse tetrameric as well as dimeric forms has opened new avenues to design novel
modulators. It is also a truism to state that drug discovery has advanced significantly from various
computational techniques like molecular docking, virtual screening, molecular dynamics, and pharmacophore
mapping. The present review focuses on the role of computational tools in exploring
novel modulators of PKM2. The structural features of various isoforms of PKM2 have been discussed
along with reported modulators. An extensive analysis of the structure-based and ligand-
based in silico methods aimed at PKM2 modulation has been conducted with an in-depth review
of the literature. The role of advanced tools like QSAR and quantum mechanics has been
established with a brief discussion of future perspectives.
Advancement in Beneficial Effects of AVE 0991: A Brief Review
Authors: Deng Yang , Ding Wangli , Peng Qiang , Wang Wei , Duan Rui , Zhang Yingdong 
Published: March 2023

Abstract:
AVE 0991, a non-peptide analogue of Angiotensin-(1-7) [Ang-(1-7)], is orally active and
physiologically well tolerated. Several studies have demonstrated that AVE 0991 improves glucose
and lipid metabolism, and contains anti-inflammatory, anti-apoptotic, anti-fibrosis, and anti-oxidant
effects. Numerous preclinical studies have also reported that AVE 0991 appears to have beneficial
effects on a variety of systemic diseases, including cardiovascular, liver, kidney, cancer, diabetes,
and nervous system diseases. This study searched multiple literature databases, including PubMed,
Web of Science, EMBASE, Google Scholar, Cochrane Library, and the ClinicalTrials.gov website
from the establishment to October 2022, using AVE 0991 as a keyword. This literature search revealed
that AVE 0991 could play different roles via various signaling pathways. However, the potential
mechanisms of these effects need further elucidation. This review summarizes the benefits of
AVE 0991 in several medical problems, including the COVID-19 pandemic. The paper also describes
the underlying mechanisms of AVE 0991, giving in-depth insights and perspectives on the
pharmaceutical value of AVE 0991 in drug discovery and development.
Molecular Targets Underlying the Neuroprotective Effects of Boswellic
Acid: A Systematic Review
Authors: Khaafi Faezeh , Javadi Behjat 
Published: March 2023

Background:
Neurodegenerative procedures include a large spectrum of disorders with
diverse pathological features and clinical manifestations, such as Alzheimer's Disease (AD), Parkinson's
disease (PD), Multiple sclerosis, and Amyotrophic lateral sclerosis (ALS). Neurodegenerative
diseases (NDs) are indicated by progressive loss of neurons and cognitive function, which is associated
with free radical formation, extra and intercellular accumulation of misfolded proteins, oxidative
stress, mitochondrial and neurotrophins dysfunction, bioenergetic impairment, inflammation,
and apoptotic cell death. Boswellic acid is a pentacyclic triterpene molecule of plant origin that has
been applied for treating several inflammatory disorders. Numerous studies have also investigated
its’ therapeutic potential against multiple NDs.

Objective:
In this article, we aim to review the neuroprotective effects of boswellic acid on NDs and
the related mechanisms of action.

Methods:
The databases of PubMed, Google Scholar, Web of Sciences, and Scopus were searched
to find studies that reported the effects of boswellic acid on NDs without time limits. Review articles,
letters, editorials, unpublished data, and articles not published in the English language were not
included in the study.

Results:
Overall, 17 studies were included in the present study (8 NDs in general, 5 AD, 3 PD, and
1 ALS). According to the reports, boswellic acid exerts anti-inflammatory, antioxidant, antiapoptotic,
and neuromodulatory effects against NDs. Boswellic acid decreases Tau phosphorylation
and amyloid-β (Aβ) generation in AD. This substance also protects nigrostriatal dopaminergic neurons
and improves motor impairments in PD and modulates neurotransmitters, decreases the demyelination
region, and improves behavioral functions in ALS.

Conclusion:
Due to the significant effects of boswellic acid in NDs, more clinical studies are necessary
to evaluate the pharmacokinetics of this substance because it seems that boswellic acid can be
used as a complementary or alternative treatment in patients with NDs.

PROSPERO Registration Number:
361020.
Identification of Important Genes Associated with the Development of
Atherosclerosis
Authors: Kotlyarov Stanislav 
Published: March 2023

Abstract:
Atherosclerosis is one of the most important medical problems due to its prevalence and
significant contribution to the structure of temporary and permanent disability and mortality. Atherosclerosis
is a complex chain of events occurring in the vascular wall over many years. Disorders of lipid
metabolism, inflammation, and impaired hemodynamics are important mechanisms of atherogenesis.
A growing body of evidence strengthens the understanding of the role of genetic and epigenetic
factors in individual predisposition and development of atherosclerosis and its clinical outcomes. In
addition, hemodynamic changes, lipid metabolism abnormalities, and inflammation are closely related
and have many overlapping links in regulation. A better study of these mechanisms may improve the
quality of diagnosis and management of such patients.