bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementary Data from Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Authors: Di Modica Martina , Gargari Giorgio , Regondi Viola , Bonizzi Arianna , Arioli Stefania , Belmonte Beatrice , De Cecco Loris , Fasano Elena , Bianchi Francesca , Bertolotti Alessia , Tripodo Claudio , Villani Laura , Corsi Fabio , Guglielmetti Simone , Balsari Andrea , Triulzi Tiziana , Tagliabue Elda 
Published: April 2023

<p>1.	Supplementary Materials and Methods Table S1. List of the antibodies used for flow cytometry 2.	Supplementary Figures Supplementary Fig. S1. Impact of antibiotic treatment on trastuzumab efficacy and the tumor microenvironment. Supplementary Fig. S2. Depletion of commensal microbiota by antibiotic cocktail (ABX) treatment and fecal microbiota transplantation. Supplementary Fig. S3. Impact of vancomycin on trastuzumab efficacy in Î"16HER2 transgenic FVB mice. Supplementary Fig. S4. Differentially abundant bacteria in the gut microbiota of antibiotic-treated mice. Supplementary Fig. S5. Short-chain fatty acids (SCFAs) quantification in fecal samples from antibiotic-treated mice. Supplementary Fig. S6. Analysis of intratumor and stromal cell staining in tumors of antibiotic-treated mice. Supplementary Fig. S7. Impact of antibiotic treatment on tumor immune infiltrate. Supplementary Fig. S8. Analysis of intratumor and stromal cell staining in tumors from FMT mice. Supplementary Fig. S9. Impact of vancomycin treatment on intestinal and systemic immune features. Supplementary Fig. S10. Impact of IL12p70 and CD4+ cell depletion on trastuzumab antitumor efficacy and on tumor immune infiltrate. Supplementary Fig. S11. Causal role of human commensal bacteria in immune-mediated trastuzumab antitumor efficacy. 3.	Supplementary References</p>
Supplementary Figure 2 from A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases
Authors: Balachandran Vinod P. , Arora Arshi , Gönen Mithat , Ito Hiromichi , Turcotte Simon , Shia Jinru , Viale Agnes , Snoeren Nikol , van Hooff Sander R. , Rinkes Inne H.M. Borel , Adam René , Kingham T. Peter , Allen Peter J. , DeMatteo Ronald P. , Jarnagin William R. , D'Angelica Michael I. 
Published: April 2023

<p>A.	Overall survival in derivation (MSKCC) and validation (European) cohorts. B.	Recurrence free survival in derivation (MSKCC) and validation (European) cohorts.</p>
Supplemental Tables 1-4 from A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors
Authors: Smith David C. , Eisenberg Peter D. , Manikhas Georgy , Chugh Rashmi , Gubens Matthew A. , Stagg Robert J. , Kapoun Ann M. , Xu Lu , Dupont Jakob , Sikic Branimir 
Published: April 2023

<p>Supplemental Tables 1-4. Supplemental Table 1: Treatment Emergent Adverse Events By Cohort (All Grades) Reported by >15% of Patients Supplemental Table 2:	Pharmacokinetic NCA Parameters by Cohort Supplemental Table 3:	Compartmental PK Analysis Final Parameter Estimates and Estimation Statistics Supplemental Table 4: RECIST Best Overall Tumor Response</p>
Toward computer-supported semi-automated timelines of future events
Authors: Lyra Alan de Oliveira , Barbosa Carlos Eduardo , de Lima Yuri Oliveira , dos Santos Herbert Salazar , Argôlo Matheus , de Souza Jano Moreira 
Published: April 2023

AbstractDuring a Futures Study, researchers analyze a significant quantity of information dispersed across multiple document databases to gather conjectures about future events, making it challenging for researchers to retrieve all predicted events described in publications quickly. Generating a timeline of future events is time-consuming and prone to errors, requiring a group of experts to execute appropriately. This work introduces NERMAP, a system capable of semi-automating the process of discovering future events, organizing them in a timeline through Named Entity Recognition supported by machine learning, and gathering up to 83% of future events found in documents when compared to humans. The system identified future events that we failed to detect during the tests. Using the system allows researchers to perform the analysis in significantly less time, thus reducing costs. Therefore, the proposed approach enables a small group of researchers to efficiently process and analyze a large volume of documents, enhancing their capability to identify and comprehend information in a timeline while minimizing costs.
Medium Small Micro Enterprise (MSME) Development and Economic Growth: Causality Analysis
Authors: Jalunggono Gentur , Sugiharti Retno , Islami Fitrah Sari , Zahroti Puji Aisyah 
Published: April 2023

As a business sector with a fairly large contribution to national output, government support for Micro, Small, Medium Enterprises (MSMEs) is increasingly being increased, even though the ratio of MSME credit to total national credit is still very small. Capital difficulties are a classic problem faced by MSMEs, but the high growth of MSMEs is a gap that shows the resilience of MSMEs. Therefore, this study wants to analyze whether the existence of MSMEs encourages economic growth, or vice versa, economic growth must be boosted to increase MSMEs. This study investigates the causal relationship and long-term stability conditions between MSME credit distribution variables and Indonesia's economic growth in the 2011 - 2019 period, using Direct Error Correction Model causality on panel data. The estimation result shows that MSME credit distribution has a positive and significant relationship to economic growth only in a long term. On the other hand, the causal relationship between MSME credit and economic growth is not proven, which means that there is no reciprocal relationship between credit and economic growth, or said in here demand following hypothesis is not proven
Effects of Graphite Flakes on the Material and Mechanical Properties of Polystyrene Membranes
Authors: Naqvi Asad A. , Awan Zahoor , Shaikh Asif Ahmed , Younas Mohammad 
Published: April 2023

Abstract
The use of polymer composite membranes has been widely increased to improve the mechanical and material properties. In this research, graphite flakes are used as nanofiller in polystyrene (PS) membrane to improve hydrophobicity, moisture blocking capacity, thermal stability, tensile strength, and gas separation ability. The membranes are prepared by a solution casting technique and are characterized by fourier transformation infrared spectroscopy, X-ray diffractometry, scanning electron microscope, thermal gravimetric analysis, water contact angle (WCA), moisture transmission rate (MTR), and mechanical testing. The prepared membranes are also tested to determine the O2 and N2 permeability and O2/N2 selectivity. The quantity of graphite flakes is varied from 0–1.0 wt% of PS. 0.7 wt% graphite-filled PS has shown the best results among all the prepared samples. The WCA of the PS membrane is increased from 97.3 to 114.803°, which shows that graphite flakes are well-suited to increase the hydrophobicity of the PS membrane. The MTR of 0.7 wt% graphite-filled PS shows that the membrane is well-suited for moisture blocking and also showed better thermal stability. Graphite flakes are also found suitable for increasing the tensile strength of the membrane. Also, the highest O2/N2 selectivity is achieved for 0.7 wt% graphite-filled membranes, which makes them suitable for gas separation operation. Furthermore, the potential application of graphite-filled PS membranes is also presented.
Cohort study of epileptic patients with family history of epilepsy
Authors: Kotov A. S. , Firsov K. V. 
Published: April 2023

Background. An impact of burdened family history on epilepsy course and disease outcome remains insufficiently studied.Objective: assessing the rate of achieving remission in epileptic patients with/without burdened family history.Material and methods. The study included 660 patients with a specified family history of epilepsy divided into three groups: Group 1 (n=192) – patients with genetic forms of epilepsy (56 with and 136 without family history); Group 2 (n=148) – patients with structural forms of epilepsy (16 with and 132 without family history); Group 3 (n=320) – patients with epilepsy of unknown etiology and unspecified epilepsy (48 with and 272 without family history). In Group 1, there were significantly more patients with burdened family history (29.2%) than in Group 2 (10.8%) (p<0.01) and Group 3 (15%) (p<0.01). ><0.01). Anamnesis collection, clinical and neurological examination, routine electroencephalography (EEG) and/or video-EEG monitoring, brain magnetic resonance imaging and analysis of medical records were carried out. Therapy was adjusted.Results. In all groups, patients with burdened family history tended to have earlier onset of epilepsy. The frequency of seizures at the onset of the disease did not depend on identified burdened family history of epilepsy. In Group 1, the effectiveness of treatment (rate of achieving remission) in both subgroups was almost identical (p>0.05), whereas in Groups 2 and 3 it tended towards a greater effectiveness of therapy in patients without family history.Conclusion. Epilepsy familial burden depends on the form of the disease and has limited prognostic value regarding disease course and likelihood of achieving remission. It is necessary to increase availability of genetic studies and identify genetic substrate of various epileptic syndromes.
Laparoscopic reversal of Hartmann’s procedure: a hospital-based prospective observational study
Authors: Lateef Khan M. Danish Bin , Saleem Mir Iqbal , Ahmad Dar Younis , Bin Masood Syed Haris 
Published: April 2023

Background: Hartmann’s procedure involves surgical resection of the rectosigmoid colon with the closure of the anorectal stump and the formation of an end colostomy. After recovery from the initial surgery, colostomy reversal and restoration of bowel continuity are indicated in selected patients. The second stage procedure is associated with a considerable morbidity rate of 10% to 50% and a modest but genuine fatality rate. Laparoscopic reversal of Hartmann’s procedure is a safe and practical alternative to the open reversal method.
Methods: This prospective observational study was conducted in the department of general surgery, GMC Srinagar over a period of 2 years after obtaining ethical clearance from the institutional ethical committee.
Results: Our study included 40 patients between the age group of 32 to 67 years, with the highest incidence between 41 to 50 years. 32 males and 8 females with a ratio of 4:1. Mean operative time was 184.6±47.06 minutes. The conversion rate to open was 10%. The mean duration of hospital stay was 6.25±2.21 days. The mean time of return to normal work was 13.4 days. Postoperatively, two patients developed ileus which was managed in the immediate postoperative period and two suffered from adhesion obstruction, managed by diagnostic laparoscopy with adhesiolysis. It remained uneventful in the rest of the patients.
Conclusions: Laparoscopic reversal of Hartmann’s procedure is safe, effective, and achieves faster positive results with significantly better short-term outcomes despite a proportion of patients being converted to open surgery.
Literature review: revisional anti-reflux surgery
Authors: Gauri Neha 
Published: April 2023

Revision anti-reflux surgery is challenging. With higher rates of complications and lower rates of symptoms control, patient selection is critical. With Roux-en-Y gastrectomy and re-fundoplication being the most commonly performed procedures, there is no clear guidance on operative selection base on patient characteristics. A literature review was performed of the PubMed database with search terms ‘reflux’, ‘gastrectomy’, and ‘fundoplication’. Of the 164 results, 17 studies were deem suitable for inclusion. In the limited studies available, Roux-en-Y gastrectomy was shown to have higher rates of symptoms control but was also associated with higher rates of complications compared to re-fundoplication. Primary studies assessing the safety and efficacy of gastrectomy as a salvage surgery option are limited. Within the available evidence, select patient groups may benefit from Roux-en-Y gastrectomy over re-fundoplication.
Immunological Responses to Helminths and HIV-1 CoInfections
Authors: Chavura Elton , Singini Wales , Chidya Russel , Mbakaya Balwani Chingatichifwe 
Published: April 2023

Aim: Helminth infections result from poor sanitation. We evaluated the effect of helminth infections on HIV disease progression through the monitoring of 2 outcomes: (1) plasma HIV-1 RNA Viral load (V/L) and (2) Cluster of Differentiation (CD4+) T-lymphocyte count amongst helminth-HIV-1 co-infected persons. We hypothesized that (1) concurrent helminth infections compromise immune control, resulting in rising VL and reduced CD4+ T-lymphocyte count (2) and that, subject to successful treatment, a decrease in plasma VL could slow down disease progression. Methods: We reviewed 2032 citations, evaluated 432 abstracts, and included 10 articles according to the PRISMA diagram. The methodologies were appraised using a Mixed Method Appraisal Tool (MMAT). Results: At enrolment, plasma VL was significantly higher in individuals with helminths (5.01 log10 vs. 3.41 log10, p < 0.001). The effective range was 5.28 log10 copies/mL at baseline and 4.67 log10 copies/mL, (p < 0.05) after treatment and a trend for 0.61 log10 lower VL. Significant interactions were seen in the successfully treated groups (p < 0.001). CD4+ T-lymphocyte count values were not significantly different in the co-infection groups relative to those with HIV infection alone.
Conclusion: Helminths and HIV-1 co-infections are associated with an increase in HIV-1 RNA levels that accelerate the progression of the sub-clinical disease to symptomatic AIDS.
Principal's Undergraduate Research Leaders (PURLs)
Authors: Principal's Undergraduate Research Leaders (PURLs)  
Published: April 2023

The Principal's Undergraduate Research Leaders, or PURLs, serve a central role in facilitating research experiences for students through advising on research, and increasing the awareness of and participation in research. they also take a leadership role in supporting studnt-led research initiatives and engaging in knowledge mobilization. In 2023, there are six PURLs, all of whom will join this panel to talk about their experiences with the program, and to provide advice to any undergraduates who may wish to apply to the program in the future.
For more information about the program and to apply please see Principal's Undergraduate Research Leaders.
Penerapan strategi inquiri terhadap hasil belajar siswa pada kelas VIII SMP
Authors: Rama Alzet , Ambiyar Ambiyar , Fadhilah Fadhilah , Dermawan Andri 
Published: April 2023

<p>Berdasarkan hasil observasi bahwa hasil belajar siswa pada mata pelajaran IPA belum mencapai kriteria ketuntasan minimum (KKM) yang telah ditetapkan, dan siswa kelas VIII kurang aktif dalam pembelajaran serta kurang semangat dalam belajar IPA. Untuk itu diperlukan strategi yang membutuhkan siswa untuk menemukan sesuatu, memecahkan masalah, dan melibatkan siswa dalam pembelajaran yaitu dengan menggunakan strategi inquiri. Penelitian ini bertujuan untuk mengetahui pengaruh strategi inquiri terhadap hasil belajar siswa pada mata pelajaran IPA kelas VIII di SMP N 2 Kota Solok.</p><p>Penelitian erbentuk kuantitatif quasy experiment. Populasi penelitian siswa kelas VIII SMPN 2 Kota Solok, dengan teknik pengambilan sampel purposive sampling, kelas VIII.1 sebagai kelas eksperimen dan siswa kelas VIII.3 sebagai kelas kontrol. Teknik pengumpulan data berbentuk tes tertulis. Alat pengumpul data adalah lembar soal dan lembar jawaban tes berbentuk obyektif sebanyak 40 butir soal. Jenis data berupa hasil belajar siswa. Sumber datanya adalah siswa. Data diolah dengan menggunakan t-test.</p>Berdasarkan hasil penelitian yang telah dilaksanakan didapatkan rata-rata hasil belajar siswa pada kelas VIII1 sebagai kelas eksperimen lebih tinggi dari pada kelas VIII3 sebagai kontrol. Hal ini dapat dilihat pada nilai rata-rata nilai 82,42 pada kelas eksperimen dan 74,67 pada kelas kontrol. Hasil analisis dengan menggunakan t-test menunjukkan hasil thitung 4,49 sedangkan ttable 2,00 pada taraf kepercayaan 0,05, sehingga thitung&gt;ttable. Hal ini menunjukkan bahwa terdapat perbedaan yang signifikan pada hasil belajar siswa yang menggunakan staregi inquiri dengan pembelajaran konvensional.
Efektivitas Konseling REBT Pendekatan Teknik Self-Talk Untuk Menurunkan Tingkat Kecemasan Akademik Siswa Kelas X SMAN “A” Denpasar
Authors: Putri Ni Kadek Rista Ary , Suarni Ni Ketut , Dharsana I Ketut 
Published: April 2023

This study aims to (1) find out the relationship between the use of the REBT counseling approach to self-talk techniques to reduce students' academic anxiety levels, (2) to know the benefits of the importance of self-talk techniques for students, (3) to find out the obstacles faced by students in the teaching and learning process in schools. The method used in this study was Pretest-Posttest Control Group Design. The subjects of this study were class X students of SMAN "A" Denpasar. Data collection was carried out using Albert Ellis's academic anxiety scale which consisted of four aspects, namely psychological, motor, cognitive, somatic totaling 35 questions. The data analysis used is Anava One Line. According to the calculation results using the <em>Statistical Packages for Social Science (SPSS) for Windows program version </em>21.0. Based on the results of the analysis obtained REBT counseling model self-talk technique is effective for reducing student anxiety levels. The result t = 14.89 at df = 51 with a significance level of 5% was obtained, then the table t value =2.00 was obtained. Based on these results, it can be concluded that the t<sub>value</sub> of calculating &gt; t<sub>table</sub> or 14.89 &gt; 2.00 is classified as having high effectiveness, meaning that there is an influence of REBT counseling self-talk techniques to reduce academic anxiety levels.
Efektivitas konseling psikoanalisa menggunakan teknik interpretasi terhadap perkembangan moral siswa SMP
Authors: Khoiriah Siti Mahmudah Amrul , Suarni Ni Ketut , Dantes Nyoman 
Published: April 2023

The purpose of this study is to determine the effectiveness of the psychoanalysis counseling model interpretation techniques on the moral development of students, looking for the tendency of moral development of students of class VII Quba Foundation and apakah counseling psychoanalysis techniques interpretation effective in the moral development of students of Quba Foundation. This study is an experimental study with a <em>pretest posttest design only one group design</em>, the population in this study is the entire Quba Foundation Junior High School, theampelous of this study is 21 people consisting of grade VII junior high school students who were taken through<em> purpose sampling</em> techniques, the data collection etode uses a moral development questionnaire of 30 items that have met the internal test of item consistency and reliability in the high category. Based on prettest data where previously there were 10 students who had a high category, after receiving classical guidance treatment psychoanalysis counseling posttest data interpretation techniques showed very high category changes, it can be interpreted as the tendency of moral development of class VII students of the Quba Foundation after getting treatment has good skills. The empirical findings in this study are a psychoanalytic counseling model of effective interpretation techniques in the development of student morale. Based on the results of the hypothesis test, the SPSS output obtained a sig value of 0.01. Because the value of sig = 0.0 1 &lt; 0.05, so it can be concluded that it is accepted that "counseling Psychoanalysis techniques of effective interpretation in the moral development of students VII of the Quba Foundation Junior High School".
Pengembangan instrumen skala kecerdasan emosional pada masa remaja siswa SMA dan SMK
Authors: Sihaloho Desi Ika Riyanti , Dantes Nyoman 
Published: April 2023

Penelitian ini dilakukan dengan tujuan menghasilkan produk berupa Instrumen Skala Kecerdasan Emosional Pada Masa Remaja Siswa SMA dan SMK Di Kota Singaraja. Penelitian ini menggunakan. Teknik pengambilan sampel menggunakan sampel random sampling atau sampel acak sederhana dengan jumlah 300 subyek atau peserta didik di kelas X. Pengumpulan data yang digunakan berupa kuesioner diukur dengan skala likert dengan 5 pilihan jawaban yang terdiri dari SS(sangat sesuai), S (sesuai),KS (kurang sesuai) TS (tidak sesuai) dan STS (sangat tidak sesuai). Berdasarkan uji ahli 5 pakar dan instrumen layak diujicobakan dengan nilai CVR (<em>content validity ratio</em>) seluruh butir yang diperoleh 49.0 dan dengan nilai CVI (<em>Content validity indeks</em>) diperoleh 0,98 atau kategori sangat sesuai. Hasil penelitian setelah dilakukan uji validitas empirik terluas hasil yang didapatkan dengan 50 butir pernyataan didapatkan hasil rentangan ɾ hitung= ≥ ɾ tabel = dengan taraf signifikansi 5% dan uji validitas konstruk memperoleh nilai KMO 0,796, nilai anti-image correlation dan nilai ekstraksi ≥ 3.0. Kemudian terbentuk 15 faktor dan hasil validasi faktor stabil dan dapat digeneralisasikan pada populasi, adapun validitas konstruk dilakukan untuk memperkuat hasil dari pengembangan yang dilakukan peneliti secara klasik.. Kemudian hasil uji reliabilitas memperoleh <em>cronbach Alpha</em> 0,815. maka dapat disimpulkan instrumen yang telah disusun oleh peneliti layak untuk digunakan sebagai layanan bimbingan konseling kepada peserta didik
Hubungan Model Discovery Learning dengan Strategi Konflik Kognitif terhadap Kemampuan Pemecahan Masalah Matematika Siswa
Authors: Siagian Dedi Saputra , Salsabila Ellis , Wiraningsih Etti Dwi 
Published: April 2023

Artikel dilatar belakangi oleh rasa keingintahuan peneliti mengenai penggunaan model discovery learning yang diintegrasikan strategi konflik kognitif terhadap kemampuan pemecahan masalah matematika siswa. Berdasarkan hasil observasi beberapa peneliti bahwa kemampuan pemecahan masalah matematika siswa masih tergolong rendah, salah satu faktor yang menyebabkan hal tersebut karena kurang efektifnya model dan strategi pembelajaran yang digunakan selama pembelajaran berlangsung di kelas. Artikel ini bertujuan untuk mengkaji hubungan antara model discovery learning dengan strategi konflk kognitif serta merancang hubungan langkah-langkah pembelajaran yang mengintegrasikan model discovery learning dengan strategi konflik kognitif terhadap kemampuan pemecahan masalah matematika siswa. Melalui rancangan pembelajaran ini diharapkan dapat digunakan dalam pembelajaran matetamatika dan mampu meningkatkan kemampuan pemecahan masalah siswa. Penelitian ini mengacu pada jenis penelitian kualitatif, yang sumber informasinya adalah literatur, artikel, majalah dan website yang berkaitan dengan penelitian yang dilakukan. Metode pengumpulan data yang digunakan dalam penelitian ini adalah studi literatur. Pencarian literatur sebagai teknik pengumpulan data kualitatif dilakukan dengan mencari dokumen yang relevan dengan topik penelitian.