bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of CD39+CD8+ T cells and CD39 and CD73 on tumor cells on the treatment response of epithelial ovarian cancer and patient outcomes
Authors: Sun Hai-Yan , Kang Shan , Wu Jian-Lei , Li Xue-Ping , Liu Yue-Ping , Yan Li 
Published: December 2022

Abstract
Objective. In this study, we evaluated whether CD39+CD8+ tumor-infiltrating lymphocytes (TILs) and CD39 and CD73 on tumor cells had an effect on survival in epithelial ovarian cancer (EOC) patients treated with platinum-based chemotherapy.
Methods. A total of 129 EOC patients between 2009 and 2015 were retrospectively reviewed. The expression of CD39+CD8+ TILs in the TME and CD39 and CD73 on tumor cells was measured by multiplexed quantitative fluorescence (QIF) on tissue microarrays (TMAs).
Results. The expression of CD39+CD8+ TILs in the TME and CD39 and CD73 on tumor cells in EOC patients was negatively associated with the response to platinum-based treatment. The area under the ROC curve of CD39+CD8+ TILs and CD39 and CD73 on tumor cells IHC image quantification for predicting the platinum resistance in EOC patients was 0.679, 0.718, 0.682; respectively. Furthermore, the protein expression of CD39+CD8+ TILs and CD39 and CD73 on tumor cells were higher in the platinum Resistant group than in the Sensitive group (P<0.01) and associated with a worse prognosis. Kaplan-Meier plots and Cox model analysis demonstrated that overexpression of CD39+CD8+ TILs and CD39 and CD73 on tumor cells was associated with a significantly shorter PFS (HR: 1.76, 95% CI: 1.20-2.56; HR: 1.64, 95% CI: 1.10-2.42; HR: 1.47, 95% CI: 0.99-2.16, respectively) and decreased OS (HR: 1.66, 95% CI: 1.12-2.47; HR: 1.78, 95% CI: 1.19-2.66; HR: 1.52, 95% CI: 1.02-2.27, respectively) in EOC patients.
Conclusion. Our results show that the expression of CD39+CD8+ TILs and CD39 and CD73 on tumor cells could be useful markers of treatment response and prognosis in EOC patients treated with platinum-based chemotherapy in Chinese women.
Integrated vortex soliton microcombs
Authors: Liu Yanwu , Lao Chenghao , Wang Min , Cheng Yinke , Fu Shiyao , Gao Chunqing , Wang Jianwei , Li Bei-Bei , Gong Qihuang , Xiao Yun-Feng , Liu Wenjing , Yang Qi-Fan 
Published: December 2022

Abstract
The frequency and orbital angular momentum (OAM)1,2 are independent physical properties of light that both offer unbounded degrees of freedom. However, creating, processing, and detecting high-dimensional OAM states have been a pivot and long-lasting task, as the complexity of the required optical systems scales up drastically with the OAM dimension3. On the other hand, mature toolboxes — such as optical frequency combs — have been developed in the frequency domain for parallel measurements with excellent fidelity4. Here we correlate the two dimensions into an equidistant comb structure on a photonic chip. Dissipative optical solitons formed in a nonlinear microresonator5 are emitted through the engraved angular gratings with each comb line carrying distinct OAM6. Such one-to-one correspondence between the OAM and frequencies manifests state-of-the-art extinction ratios over 18.5 dB, enabling precision spectroscopy of optical vortices. The demonstrated vortex soliton microcombs provide coherent light sources that are multiplexed in the spatial and frequency domain, having the potential to establish a new modus operandi of high-dimensional structured light.
HER2-negative or low expression as an unfavorable prognostic factor in patients with stage I/II uterine carcinosarcoma
Authors: Mizoguchi Chiharu , Nishikawa Tadaaki , Yoshida Hiroshi , Yamamoto Kasumi , Kitadai Rui , Sudo Kazuki , Shimoi Tatsunori , Miwa Maiko , Sato Sho , Shintani Daisuke , Kato Tomomi , Yano Mitsutake , Yasuda Masanori , Hirakawa Akihiro , Kato Tomoyasu , Hasegawa Kosei , Yonemori Kan 
Published: December 2022

Abstract

Objective
Uterine carcinosarcoma (UCS) is uncommon high-grade endometrial cancer with limited treatment options. We evaluated prognostic significance of HER2 expression and HER2 gene amplification within large cohorts of UCS, and clarify clinicopathologic characteristics of HER2-low UCS.
Methods
We examined HER2 protein expression in 148 patients of UCS using IVD HER2 immunohistochemistry (IHC) kits and HER2 gene amplification using FISH in 72 patients.
Results
HER2 IHC score was evaluated according to the latest ASCO/CAP criteria for gastric cancer, which was negative in 41 patients, low expression of 1 + was observed in 57 patients, and HER2 high expression was observed in 50 patients (2 + in 38 and 3 + in 12 patients). There was no significant statistical difference in clinicopathological characteristics based on HER2 protein expression status. HER2 negative and low expression compared to high expression revealed poor overall survival in stage I/ II. The concordance between IHC and FISH results were relatively low compared to other cancer types (HER2 IHC score 1+, 2+, and 3 + were 5%, 15%, and 50%), and combining these results was not efficient as a prognostic factor in UCS. In contrast, HER2 IHC score alone was a prognostic factor in stage I/II UCS. HER2 low group did not show specific clinicopathologic feature.
Conclusions
Since the HER2 IHC score low in advanced UCS is a predictive factor, stratification of UCS using HER2 IHC score for HER2 IHC score low group and developing adjuvant therapy may be proposed in the near future.
When a rectal tube saves a life in an ECMO patient
Authors: Forti Alessandro , Torre Debora Emanuela , Tini Laura , Disarò Laura , Mangino Domenico , Lazzari Francesco 
Published: December 2022

Abstract
Background:
This article shows the concrete possibility to resolve important hypotension during assistance with ECMO by doing simple maneuvers.
The abdominal fluid overload and hypertension is a problem probably a little underestimated and underestimated during the post-cardiac arrest reperfusion phase.
Our clinical case shows how an important intra-abdominal hypertension developed and how it was treated just a few hours after the implantation of the post refractory cardiac arrest ECMO.
Case presentation
We describe a case of cardiac arrest in a 47-year-old male, 80kg, with history of moderate hypertension. Cardiac arrest happened in the patient’s house, in the presence of his wife. She immediately called for aid. 1 minute after the event cardiopulmonary resuscitation (CPR) was started by a policeman (BLS performer). 20 minutes later the Emergency Medical Service (EMS) arrived. The cardiac rhythm of presentation was a ventricular fibrillation (VF).
Forty minutes after the event, the EMS arrived with a declared ongoing CPR protocol at the cath-lab at Angel’s Hospital in Mestre (Venice). 50 min after the event a veno-arterial ECMO support was started. 3 hours after the admission in the ICU, we observed a sudden hemodynamic instability, characterized by hypotension, MAP < 60 mmHg, increase in lactates, drastic decrease in ECMO blood flow (1,5-1,8 lpm) despite > 3000rpm.
The abdomen was expanded and stiff. The intra-abdominal pressure (IAP) (measured by Unometer Abdopressure Convatec USA) was 18 cmH2O. A naso-gastric tube and a rectal tube (Rectal tube, Bicakcilar- Istanbul, Turkye) were placed. The drainage from the rectal tube was 2500ml of liquid stools in 2 hours. The IAP dropped to 9 cmH2O, and ECMO blood flow raised to 3.2 lpm. The drainage gave to the ECMO a correct blood flow returns from the cannulas and the return to a normal BF.
Conclusion
We recommend is a careful assessment of intra-abdominal pressure in the first 24 hours after the ECMO implant to prevent any drops in flow and systemic pressure.
Comparison of the levels of mental health at the different times of coronavirus disease 2019 in China college student
Authors: Zhou Qi , Li Qiong , Han Panpan , Zhuang Wenhao , Zhang Yuanyuan , Zhou Dongsheng , Bian Guolin 
Published: December 2022

Abstract
Objective: Comparing levels of mental health including general psychological symptoms, stress and insomnia among college students at different times during the 2019 coronavirus (COVID-19) epidemic in China.
Methods: Two cross-sectional survey studies were conducted with 503 isolated college students through the questionnaire STAR platform. Of these, 300 students participated in February 2020 and 203 students participated in May 2022. Information collected included demographic and psychological stress measures, mental health scales including the Athens Insomnia Scale (AIS) to assess sleep, the Self-Report Questionnaire (SRQ-20) to assess general psychological symptoms, and the China Perceived Stress Scale (CPSS) to assess stress. ANOVAs were conducted on factors associated with mental health outcomes.
Results: From 2020 to 2022, levels of insomnia (p=0.001), anxiety/depression (p=0.001) and stress (p<0.001) decreased significantly. in February 2020, 42.67% of participants exhibited symptoms of insomnia, 16.67% exhibited anxiety/depression symptoms and 96.67% exhibited stress symptoms. in May 2022, the percentage of insomnia decreased to 28.08%, anxiety/depressive symptoms to 6.90% and stressful situations to 68.97%.
Conclusions: During the COVID-19 disease pandemic, college students participating in the survey had significantly better sleep, significantly lower levels of anxiety and depression, and lower levels of stress in 2022 compared to 2020. Despite this, high levels of stress remain, indicating that college students are suffering from a high psychological burden, and targeted interventions to promote mental health are recommended.
On Newton’s law of cooling with time delay and Ψ-Caputo fractional derivatives
Authors: Hatime Naoufel , Melliani Said , Mfadel Ali El , Baleanu Dumitru , Elomari Mhamed 
Published: December 2022

Abstract
In this paper, we study fractional delayed Newton’s law of cooling involving Ψ-Caputo fractional derivatives of order α ∈ (0, 1). The existence and uniqueness of solutions for our proposed model are derived from Banach fixed point theorem, Henry–Gronwall inequalities and some basic tools of Ψ-Caputo fractional calculus. In addition, a novel finite time stability criterion and some estimate results of solutions with time delay are established by using heat transfer model. We give also some specific examples with graphs and numerical experiment to illustrate the obtained results. More importantly, the comparison of model predictions versus experimental data, classical model and non-delayed model show the effectiveness of our proposed model with a reasonable precision.
Implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning, a mixed-methods systematic review protocol
Authors: Nabhan Ashraf , kabra Rita , Kiarie James 
Published: December 2022

Abstract

Objectives: This review aims to describe and assess the quality of the evidence on implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning.
Search methods: We will search the following electronic bibliographic databases (from inception to 15th October 2022): MEDLINE, PubMed, Scopus, the Cochrane Library, and Global Index Medicus, World Health Organization. We will also search gray literature using the search engines and websites of relevant organizations. We will hand search citations in included articles. We will contact experts and groups of scientists in the field for relevant reports.
Selection criteria: We will include reports of primary studies on scaling up post pregnancy family planning. We will include studies conducted in any country, language, and publication date. We will not exclude studies based on methodological limitations.
Data collection and analysis: We will assess titles and abstracts then potential full-text papers according to the inclusion criteria. We will include reports that met the inclusion criteria. We will extract information including country, country's economic category, study type and design, strategies of scaling up post pregnancy family planning, implementation outcome evaluated in each study, and barriers and facilitators. We will use a deductive thematic synthesis process. We will use GRADE-CERQual to assess our confidence in the findings
Results: This is a protocol for a mixed methods systematic review. The review will summarize reports used either separate or bundled strategies for scaling-up post pregnancy family planning. These include strategies for healthcare infrastructure, policy and regulation, financing, human resource, and people at the point of care. We will summarize the factors that influence scaling up post pregnancy family planning.
Discussion: The results of the review will be disseminated and can contribute to the development of guidance and programmatic tools for planning, implementing, and evaluating scaling up of post pregnancy family planning.
Profiles of LncRNAs expression in Schistosoma mansoni during intra- mammalian development
Authors: Rocha Flávia Arêdes , Oliveira Victor Fernandes , Castro-Borges William , Cabral Fernanda Janku , Guerra-Sá Renata 
Published: December 2022

Abstract

Background
Schistosomes infect over 200 million people, resulting in chronic disease and hundreds of thousands of deaths. It is believed that the complexity of the differentiation and developmental programs observed among the different developmental stages and in the environments where the parasite lives are influenced by the regulation of gene expression. In this scenario, long noncoding RNAs (lncRNAs) would be key molecules. Recently, our research group identified a set of 170 new lncRNAs in Schistosoma mansoni, and 15 were experimentally analyzed. Continuing this investigation, we evaluated the expression of 47 of these lncRNAs in S. mansoni developmental stages, as well as in liver samples of a murine schistosomiasis model.
Methods
We experimentally analyze 47 S. mansoni lncRNAs, and the validated ones had their expression analyzed using RT-qPCR in samples of the definitive-host-related developmental stages of the worm: cercariae, schistosomula 3.5 h, adult worms, and eggs; as well as in liver samples of BALB/c mice infected (100 cercariae) and uninfected, collected 9 weeks post-infection. Putative target protein-coding genes expression and Gene Ontology were collected in WormBase Parasite.
Results
We demonstrate that 25 of the 47 lncRNAs analyzed were primarily expressed in adult worms. 20 of these also show to be differentially expressed among the developmental stages evaluated, demonstrating that these molecules probably play a role in stage-specific gene expression. We also detect the expression of 22 S. mansoni-specific lncRNAs host liver samples, suggesting the action in the host-pathogen relationship. Finally, we describe lncRNA–protein coding gene correlations that identify lncRNAs with prospective roles in gene regulation.
Conclusions
Our results show clear differential expression patterns of lncRNAs in host-dependent development stages of S. mansoni and ascribe potential functional roles in development based on predicted intracellular interactions as well as potential for being biomarkers.
Cancer-malnutrition care beyond the hospital walls: a survey of nutrition governance, practice, knowledge and education needs in the primary care and community sector in Australia
Authors: Stewart Jane , Kiss Nicole , Simmance Natalie , Kelaart Amber , Loeliger Jenelle 
Published: December 2022

Abstract
Purpose
Cancer-related malnutrition remains a prevalent issue in cancer survivorship. This study aimed to understand cancer-related malnutrition practice, knowledge and education needs in the primary care and community sectors, as well as the transition of nutrition care from hospital cancer services following cancer treatment.
Methods
A cross-sectional survey was conducted with general practitioners (GPs), general practice nurses (GPNs) and dietitians in hospital cancer services, community services and primary care in Victoria, Australia.
Results
The 184 respondents represented dietitians (n = 152), GPs (n = 22) and GPNs (n = 10). GPs and GPNs, and dietitians working in primary care and community settings (78% and 63%, respectively) agree cancer malnutrition is going unrecognised in their service. Only 26% of community health services complete malnutrition risk screening and 35% of GPs and GPNs frequently weigh their patients with cancer. Most GPs and GPNs (88%) believe responsibility for malnutrition risk screening should be shared across disciplines and 94% would like access to a malnutrition screening tool. Only 32% of hospital oncology dietitians and 44% of GPs and GPNs frequently refer their patients to primary care or community dietitians.
Conclusion
Implementation of routine malnutrition risk screening in primary care and community services and improved transition of nutrition care between hospital, primary care and community practitioners is required. Targeted cancer malnutrition education and resources across all health sectors is warranted.
Trehalose and Isomaltulose in the Technology of Sweetened Condensed Milk
Authors: Bolshakova Ekaterina 
Published: December 2022

Sucrose is an important component in many foods. However, it can be dangerous for consumers’ health, if overconsumed. For instance, it may cause tooth decay. As a rule, sucrose provides sweetness and a certain dry matter content. Alternative sweeteners and bulking agents can also perform these two functions. Unfortunately, they almost always fail to serve as an osmotically active agent in canned products. The research objective was to study the properties of trehalose and isomaltulose as sugar substitutes in sweetened condensed milk.
The study covered fifteen years of domestic and foreign research reported in the open databases of the Russian Scientific Citation Index, Scopus, and Web of Science. The list of search descriptors included twelve words and word combinations, e.g., sweetened condensed milk, water activity, sucrose, trehalose, isomaltulose, etc.
The review focused primarily on the important properties of sucrose in the sweetened condensed milk and the physico-chemical features of the milk system. The analysis provided a system of criteria to evaluate the optimality of alternative substances for sweet concentrated milk production. These criteria were applied to trehalose and isomaltulose.
The article introduces a list of criteria that can be used to evaluate sweeteners and sugar substitutes as regulators of certain technological properties in the production of sweetened concentrated milk products with intermediate moisture content. According to these criteria, trehalose and isomaltulose can serve as alternative sweeteners in condensed milk. However, the review revealed some gaps in experimental data on a number of properties of considered carbohydrates in sweetened concentrated milk products, which imposes further research.
Developing a Herbal Drink from Green Asparagus (Asparagus officinalis L.): Effect of Process Parameters on the Quality of the Product
Authors: Nguyen Quang Vinh , Le Dang Pha , Nguyen Minh Trung , Tran Thi Yen Nhi , Le Dang Truong 
Published: December 2022

Green asparagus is widely consumed fresh due to its high nutritional value and a low calorie content. However, its short shelf-life due to a high water content causes high postharvest losses. In this study, we aimed to develop an innovative asparagus herbal drink to ease postharvest losses and diversify asparagus-derived products.
We investigated the effects of process parameters on the quality of the herbal drink from green asparagus. In particular, we determined the optimal length and grinding size for asparagus and selected suitable blanching and drying methods. Analytical responses included the contents of total soluble solids, polyphenol, carbohydrates, and vitamin C, as well as the visual appearance of asparagus samples.
The length of 5 mm was found suitable for subsequent steps as it facilitated an increase in solute in the asparagus infusion. Microwave blanching and convective drying were selected to achieve high contents of total soluble solids, polyphenol, carbohydrates, and vitamin C in the asparagus infusion. Dried asparagus ground into 1.5–2.0 mm particles was packaged into tea bags. The asparagus infusion subjected to sensory evaluation had a yellowish color, a characteristic asparagus flavor, and a relatively sweet taste. Total soluble solids in the infusion amounted to 26%.
Our results showed a possibility of developing an asparagus herbal drink which could be a potent product in the commercial market. Therefore, further large-scale studies of the asparagus herbal drink should be carried out to enhance its feasibility in the food industry.
Effect of Ionising Irradiation on Wheat Flour
Authors: Romanov Aleksandr , Markov Aleksandr , Sergeeva Irina , Kozubaeva Lyudmila , Protopopov Dmitry 
Published: December 2022

Radiation processing suppresses the development of microorganisms and pests in food products. This method is safe and does not affect nutritional value; however, it may change the properties of starch and proteins. The research objective was to define the effect of ionization on the baking properties and safety indicators of wheat flour.
The study featured wheat flour subjected to gamma irradiation at 0–47.52 kGy, as well as dough and bread made from this flour. The flour samples were tested for the radioactivity of radionuclides; a set of experiments revealed their microbiological indicators and falling-number values. The dough samples were studied on an Alveograph and a Mixolab analyzer to define their structural and mechanical properties. The quality of bread was evaluated by its specific volume, shape stability, and sensory profile.
The flour proved safe in terms of residual gamma radiation after 24 and 72 h. At the maximal dose of gamma radiation, the total viable count of mesophyll aerobic and optional-anaerobic microorganisms decreased by fifteen times, whereas the amount of mold decreased by five times. The total strain energy, elastic properties, and elasticity index of the dough declined by more than 50%. The dough had a lower stability during kneading. Its gelatinization onset started earlier by 2.3–3.3°C. The falling number decreased by more than four times, probably, due to the changes in the state of wheat starch. The bread samples had a smaller specific volume and a lower dimensional stability. They also demonstrated signs of darkening, stickiness, and crumb crushing at the maximal irradiation dose (47.52 kGy).
The microbiological safety indicators of wheat flour increased at the maximal irradiation dose. However, the baking properties of flour decreased. The sensory and physicochemical parameters of bread quality started to deteriorate at ≥ 23 kGy. Therefore, ionization cannot be recommended as a disinfection method for baking wheat flour production.