bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOHaD: A MENAGERIE OF ADAPTATIONS AND PERSPECTIVES: Large animal models of developmental programming: sustenance, stress, and sex matter
Authors: Hammer CJ , Caton JS , Dahlen CR , Ward AK , Borowicz PP , Reynolds LP 
Published: March 2023

In brief
Developmental programming refers to the long-term programming of gene expression during fetal and postnatal development, resulting in altered organ function even into adulthood. This review describes how maternal and paternal sustenance and stress, as well as fetal sex, all matter in large animal models and affect developmental programming of the offspring.

Abstract
Developmental programming is the concept that certain health outcomes throughout life can be linked to early fetal or postnatal development. Progress in understanding concepts and mechanisms surrounding developmental programming is heavily leveraged by the use of large animal models. Numerous large animal models have been developed that apply a host of different maternal stressors and, more recently, paternal stressors. Maternal nutrition is the most researched maternal stressor applied during gestation and includes both global nutrient supply and models that target specific macro- or micro- nutrients. The focus of this review is to provide an overview of the many large animal models of developmental programming and to discuss the importance of sex effects (including paternal contributions) in study design and data interpretation.
Perfil de Agenciamento dos Chief Executive Officers de maior sucesso no Brasil: O caso Forbes e a relação com remuneração executiva.
Authors: Oliveira Alexandre Silva de , Sonza Igor Bernanrdi de , Von Ende Marta _ 
Published: March 2023

Este trabalho objetiva analisar o perfil de agenciamento dos Chief Executive Officers (CEOs) de maior sucesso no mercado Brasileiro segundo a classificação FORBES. A base teórica que fundamenta o trabalho é a teoria do Valor Econômico Criado (VEC) de Malvessi (2001). Como metodologia busca-se replicar o procedimento descrito pela revista para premiar os agraciados no ano de 2019, com a utilização do Valor Econômico Criado (VEC), do ano de 2018 e do valor médio do VEC entre 2010 e 2018. Também trata os dados em painel para análise da relação entre a remuneração dos executivos e o VEC. Na validação os resultados das empresas ativas na Bovespa, totalizando 417 empresas, são analisados durante o mesmo período. Apesar dos premiados serem profissionais experientes e qualificados, os resultados não confirmaram o ranqueamento estabelecido pela Forbes e apontam que a remuneração dos executivos não é uma boa variável para explicar o desempenho das empresas no VEC. Este trabalho contribui para a literatura e para a prática, uma vez que não se encontram trabalhos publicados, avaliando a transparência e confiabilidade das premiações e ranqueamento do desempenho dos profissionais do mercado.
Optimización del proceso de hidrólisis enzimática de dextrano en jugo de caña de azúcar (Saccharum officinarum) utilizando la metodología de superficie de respuesta
Authors: Chía-Concepción Carol , Sotelo-Ganoza Kimy , Castillo-Calderón Augusto , Diestra Balta Jesús 
Published: March 2023

El dextrano es un homopolisacárido de glucosa, formado en el jugo de caña de azúcar durante la postcosecha y es responsable de los bajos rendimientos de la evaporación y cristalización en la industria azucarera. La sacarificación enzimática del dextrano se ha destacado por sus rendimientos satisfactorios; sin embargo, dicho proceso enzimático requiere de una adecuada selección de la enzima y su concentración, así como el control de las condiciones ambientales de la biocatálisis. El objetivo de la presente investigación fue optimizar el proceso de hidrólisis enzimática de dextrano del jugo de caña de azúcar mediante la metodología de superficie de respuesta. Se utilizó un diseño central compuesto rotacional con tres factores independientes de cinco niveles: concentración de enzima, tiempo y temperatura de reacción y como variable respuesta: la reducción de la concentración de dextrano. Se utilizó la enzima comercial Dextranfree Xe la cual fue caracterizada cinéticamente. El experimento consistió en dos etapas, primero se utilizó un medio simulado de jugo de caña para determinar las condiciones óptimas y éstas aplicarlas después al jugo real de caña de azúcar. Las condiciones ambientales óptimas de hidrolisis del dextrano en el simulado de jugo de caña resultaron ser: concentración de enzima 224 ppm, tiempo de reacción 32 minutos y temperatura de reacción 36 °C, para alcanzar un 70% de reducción de dextrano. Finalmente, las condiciones optimizadas fueron validadas aplicándolas al jugo de caña de azúcar, obteniéndose una reducción del 69.2% de concentración de dextrano; concluyéndose que dicho método fue efectivo.
Correlation model between PM2.5 and atmospheric variables in the city of Villavicencio
Authors: Cuéllar Guarnizo Jairo Alberto , Isaza Domínguez Lauren Genith , Hernández Alonso Eduardo Jesús 
Published: March 2023

Introduction: This article is the product of the research "Monitoring and Characterization of air quality in the downtown area of Villavicencio", carried out from 2018 to 2020 in Villavicencio - Colombia.
Problem: Air quality directly impacts the health of the people who breathe it. Currently Villavicencio does not have enough monitoring stations, nor are there strategies to improve air quality.
Objective: The main objective is to collect and analyse atmospheric and air quality information, to determinate the relationship between atmospheric variables and particulate matter.
Methodology: Quantitative and experimental research in stages, a number of samples to be taken were defined and a statistical treatment was carried out. Different instruments were used to collect the variables.
Results: The linear model between particulate material and atmospheric variables was obtained. The correlation index of particulate material with atmospheric variables was determined. The results were compared with regulations in Colombia and other countries.

Conclusion: The results are within the limit allowed by national regulations. Linear models of the relationship between environmental variables and particulate matter were obtained.
Originality: There are few studies related to air quality in the region. With the results, improvement actions can be proposed to local administrations to mitigate the impact on air quality in Villavicencio.
Limitations: Sample collection time was limited, the availability of equipment in the institution where the research work originated also affected the scope of the work carried out.
Examining the Ability of Title IX to Provide Equitable Participation Opportunities for Black Women College Athletes
Authors: Flowers Courtney , Hamilton Jasmine , Olushola Ogunrinde Joyce 
Published: March 2023

The purpose of this study was to reveal Title IX fueled obstacles which prevent Black women from achieving equity in college sports. The researchers sought to provide a critical analysis of the synchronous burden of race and gender discrimination experienced by Black women in college sports. The study found this form of discrimination is unique to Black women as they experience sex discrimination similar to white women and race discrimination similar to Black men, but neither white women or Black men experience simultaneous forms of race and gender discrimination as Black women do (Crenshaw 1988; Mathewson; 1996). Title IX is a single-axis equity law which uses sex to factor discrimination, yet as Black women experience both race and gender discrimination synchronously this law does not protect Black women from discrimination in the way they experience it. Yet, examining the effectiveness of Title IX to prevent race and sex discrimination is problematic because even with the law, schools have not achieved gender equity in college sports since its enactment in 1972 (Butler & Lopiano, 2003; Cooper & Newton, 2021;Kaplan, Hecker, & Fink, 2021; NWLC, 2022; Staurowsky, 2011; 2020; 2022). Another challenge is the NCAA Emerging Sports Program for Women uses a single axis lens to increase athletic opportunities for women. Therefore Black women are barred from benefiting from the increased access and athletic opportunities produced through the Emerging Sports program as it uses sex as a solo determinant to increase athletic opportunities. It is worth noting the extreme lack of research on Black women in sports has rendered Black women college athletes invisible in data on women’s sports (Butler & Lopiano, 2003; Carter-Francique & Flowers, 2013; Cooper & Newton, 2021; McDowell & Carter-Francique, 2017; Pickett et al, 2012; Staurowsky et al., 2021; 2022). This adds to the complexity of examining forms of discrimination experienced by Black women in college sports. The study found racial clustering, the single-axis lens of Title IX, and NCAA gender equity programs collectively provide harm to Black women in college sports and uniquely attack their ability to achieve equity in college sports.
Artificial intelligence technology in MR neuroimaging. А radiologist’s perspective
Authors: Trufanov G. E. , Efimtsev A. Yu. 
Published: March 2023

Artificial Intelligence (AI) has been the subject of particular interest in the field of radiology in recent years. Experts believe that the development and implementation of AI technologies will improve diagnostic accuracy, speed up the acquisition of objective information, reduce its variability, and optimize the workflow of diagnostic departments of medical institutions. Over the years, AI has evolved from simple rule-based systems to sophisticated deep-learning algorithms capable of analysing medical images with high accuracy.Despite some progress, the use of AI in medical imaging is still limited. There are many challenges that need to be overcome before it can be widely adopted in clinical practice. For example, training AI algorithms require large amounts of high quality annotated data, and such data is not yet available for the bulk of pathology and any of the imaging techniques. This article looks at the possibilities of AI and some of the current challenges associated with the application of AI in neuroimaging.
Sintesis Carbon Nanofoam dan Karakteristiknya
Authors: Muchlisha Nuryah , Widjonarko Dian Maruto , Saraswati Teguh Endah 
Published: March 2023

<p>Karbon memiliki kemampuan untuk membuat jaringan ikatan hibridisasi sp, sp‒sp<sup>2</sup>, sp<sup>2</sup>, sp<sup>3</sup>, dan sp<sup>2</sup>‒sp<sup>3</sup>,sehingga karbon terdapat dalam banyak bentuk alotrop seperti grafit, <em>diamond</em>, <em>graphene</em>, <em>nanofiber, nanofoam, </em>dan<em> nanotube</em>. <em>Carbon</em> <em>nanofoam</em> (CNF) terbentuk dari atom karbon yang terikat secara sp<sup>2</sup> dan sp<sup>3</sup>. CNF memiliki struktur sel terbuka yang saling berhubungan, densitas yang sangat rendah, stabilitas termal yang tinggi, dan porositas yang tinggi. CNF<em> </em>dapat diperoleh dengan menggunakan berbagai metode seperti <em>chemical vapor depositon</em>, laser ablsasi<em>, arc-discharge</em>, dan pirolisis. Sintesis dengan berbagai jenis sumber karbon dan keadaan eksperimen menghasilkan material yang memiliki berbagai ukuran, luas permukaan, dan strukturnya. Struktur CNF terdiri dari dua jenis berdasarkan pola tepi strukturnya yaitu <em>zigzag</em> dan <em>armchair</em>. Hasil karakterisasinya menunjukkan bahwa CNF lebih banyak mengandung karbon dengan hibridisasi sp<sup>2</sup> dengan struktur yang berinterkoneksi<em> </em>satu sama lain dan memiliki densitas yang sangat rendah. Selain itu, material ini juga memiliki pori dalam ukuran mesopori dan luas permukaan yang tinggi. Sifat unik yang dimiliki oleh CNF<em> </em>berpotensi diaplikasikan dalam berbagai bidang seperti filter, superkapasitor, dan <em>energy storage</em>. </p><p><strong>Synthesis of Carbon Nanofoam and Its Characteristics. </strong>Carbon can create sp, sp‒sp<sup>2</sup>, sp<sup>2</sup>, sp<sup>3</sup>, and sp<sup>2</sup>‒sp<sup>3</sup> hybridized bond networks, which make carbon in many allotropes forms such as graphite, diamond, graphene, nanofiber, nanofoam, and nanotubes. Carbon nanofoam (CNF) is formed by sp<sup>2</sup> and sp<sup>3</sup> bonded carbon atoms. CNF has an interconnected open-cell structure, very low density, high thermal stability, and high porosity. CNF is obtained using several methods, such as laser ablation, arc-discharge, chemical vapor deposition, and pyrolysis. Synthesis with various types of carbon sources and experimental conditions resulted in materials having various sizes, surface areas, and structures. The structure of CNF consists of two edge pattern types, including zigzag and armchair. The characterization results show that CNF contains more interconnected carbon with sp<sup>2</sup> hybridization and has a very low density. In addition, this material also has pores in the mesoporous size and high surface area. The unique properties of CNF provide potential applications in various fields, such as filters, supercapacitors, and energy storage.<strong></strong></p>
Performance Analysis of ECC Using RK and GT Method for Aadhaar Card
Authors: Lizy Felista Sugirtha , Raj Joseph 
Published: March 2023

Abstract
In the Aadhaar Card, security is a major issue. As the data once to be kept as private as possible, we will require some data-handling strategies. This document would be useful for data security. The advantage of this technique is in terms of text encryption and decryption security. Asymmetric algorithms include RSA (Rivest, Adi Shamir, and Leonard Adleman) and ECC (Elliptic Curve Cryptography). The cryptographic algorithms RSA and ECC are used to create a pair of keys, a public key, and a private key. The performances of the RK (Runge-Kutta) algorithm with ECC and the GT (Game Theory) with ECC method are compared in this study. Combining the ECC Method and the RK with GT Method improves the speed and security of this paper. The Avalanche Effect, Speed, Throughput, and Power Consumption of the RK-GT-ECC algorithm is recommended to be improved. The experimental findings of the RK-GT-ECC algorithm show increased performance. There is also a detailed mathematical justification for the use of the RK-GT-ECC algorithm. The improved performance of the RK-GT-ECC approaches, as well as experimental findings, are discussed.
Adapting group-based postpartum and well-child care using a human-centered design approach in Malawi
Authors: Gresh Ashley , Batchelder Anne , Glass Nancy , Mambulasa Janet , Kapito Esnath , MacDonald Amy , Ngutwa Nellie , Plesko Cori , Chirwa Ellen , Patil Crystal 
Published: March 2023

Abstract

Background. Responsive and resilient strategies to reduce the high rates of maternal and infant mortality and clinician shortages are needed in low- and middle-income countries (LMICs). Malawi has some of highest maternal and infant mortality rates globally. Group-based healthcare is one such strategy to improve maternal and child health outcomes. Group-based care has been applied to the perinatal period, but less attention has been paid its potential benefits in postpartum care. The postpartum period is a period of opportunity for innovative approaches to engage mothers and children in care and contribute to the reduction of maternal and infant mortality and morbidity. We present the adaption of an evidence-based group-based perinatal care model to the postpartum period using human centered design with key stakeholders in Malawi.
Methods. To adapt the perinatal group-based care model for the Malawian context, the team completed four steps of a five-step framework guiding the use of human centered design: 1) define the problem and assemble a team; 2) gather information through evidence and inspiration; 3) synthesize; and 4) intervention design: guiding principles and ideation. Steps 2-4 relied on qualitative methods, in-depth interviews, and incubator sessions with key stakeholders to produce a prototype of the group-based postpartum care model.
Results Once the stakeholders had defined the problem of limited postpartum care in the context and assembled local and global team members, we completed 20 interviews and 6 incubator sessions with stakeholders. All stakeholders reported a desire to participate in and offer group care in the postpartum period in their community. Health promotion priorities identified were hygiene (e.g., perineal care), breastfeeding, family planning, nutrition, and mental health. The recommended group-based care implementation schedule includes 6 sessions that corresponds with the child vaccination schedule over the 12-month postpartum period. A prototype for the curriculum and implementation structure for group postpartum and well-child care was created based on the findings.
Conclusions A human centered design approach to adapt an evidence-based group-based care approach to an LMIC, Malawi is feasible and acceptable to key stakeholders and resulted in a prototype curriculum with practical strategies for implementation in the health care setting.
Semi-supervised consistency regularization for accurate cell type fraction and gene expression estimation
Authors: Khatri Robin , Machart Pierre , Bonn Stefan 
Published: March 2023

Abstract
Cell deconvolution is the estimation of cell type fractions and cell type-specific gene expression from mixed data with unknown composition. In biomedical research, cell deconvolution, which is a source separation task, is used to obtain mechanistic and diagnostic insights into human disease. An unmet challenge in cell deconvolution, however, is the scarcity of realistic training data and the strong domain shift observed in synthetic training data that is used in contemporary methods. Here, we hypothesize that simultaneous consistency regularization of the target and training domains will improve deconvolution performance. By adding this novel biologically motivated consistency loss to two deep learning-based deconvolution algorithms, we achieve state-of-the-art performance on both cell fraction and gene expression estimation. Our method, DISSECT, outperforms competing algorithms across several gene expression datasets and can be easily adapted to deconvolve other biomedical data types, as exemplified by our spatial expression deconvolution experiments.
GERD symptoms often improve after magnetic sphincter augmentation (MSA) device removal – an observational study
Authors: Buniak Nicholas , Buniak Borys , Maini Atul , Sivakumar Balasubramanian , Sun John , Jantsch Stacey , Obrien Danielle L. , Frey Tara 
Published: March 2023

Abstract
Hypothesis: Magnetic Sphincter Augmentation device causes fibrosis at the distal esophagus which prevents reflux even after device removal
Background: Gastroesophageal reflux disease (GERD) affects over 20 million people in the United States. If left untreated, chronic reflux of gastric contents into the distal esophagus may result in benign or malignant esophageal strictures, causing varying degrees of dysphagia. We currently offer interventions which artificially create a narrowing at the distal esophagus to prevent complications of GERD. Magnetic Sphincter Augmentation device (MSA), or LINX, creates such a narrowing of the distal esophagus at the level of the LES. Individuals intolerant of this device need surgical removal which leaves scarring at the site of implantation.
Methods: There were 118 MSA devices placed at our institution between 2017 and 2021. During this time, 8 out of 118 (6.7%) patients needed to have their LINX removed due to side effects attributed to the implant. Causes for removal included esophageal perforation, dysphagia or hypersensitivity related chest pressure presumably caused by the device. Patients, who have had the LINX device removed, were followed for recurrence of reflux using Barium Swallow imaging, endoscopic findings and GERD-HRQL scores.
Results: The longer the MSA implants remained before removal, the more extensive the scar tissue encountered at site of excision. Five of eight patients (62%) experienced improvement in their GERD-HRQL scores after removal of the MSA device when compared to results before LINX implantation. The residual band of scar tissue observed after device removal appeared to control reflux by restricting the relaxation of the esophageal outlet.
Conclusions: These results indicate that fibrosis at the site of MSA device removal improves heartburn symptoms in a majority of patients. We do not recommend fundoplication at time of LINX removal as symptoms of GERD may be adequately controlled by scar tissue at the LES.
Deployment Method of Wireless Sensor Networks based on MaOEA/P-GM Algorithm
Authors: Wang Jun , Luo Dongxu , Chen Weiru , Peng Funan , Li Zhiwu 
Published: March 2023

Abstract

At present, wireless sensor networks are developing rapidly, but they will also face many challenges. In the deployment problem, many problems such as cost, coverage, connectivity, energy, network life cycle and so on need to be considered, while the traditional multi-objective algorithm does not perform well in dealing with many-objective problems. How to quickly find high-quality solutions is the focus of research today. This paper proposes a deployment method for wireless sensor networks based on a many-objective evolutionary algorithm with guided mutation. This method improves the mutation strategy of the algorithm according to the characteristics of wireless sensor network deployment based on a many-objective evolutionary algorithm based on the projection plane. Experiments show that using this algorithm in a many-objective environment can quickly get a high-quality solution set with fewer nodes, high coverage, good connectivity and balanced energy consumption.
Comparison of cerebral hemodynamics among hemodynamically stable preterm (28 0/6- 34 6/7 weeks) small for gestational age (SGA) and appropriate for gestational age (AGA) neonates during the first 72 hours of life: A Prospective Cohort Study
Authors: Gupta Priyanka , Oleti Tejo Pratap , Deshabhotla SaiKiran , Vardhelli Venkateshwarlu , Narala Sadhana , Nair Shruthi 
Published: March 2023

Abstract
Background: Transition from fetal to extra uterine circulation is a poorly understood process in terms of cerebral hemodynamics. Postnatal cerebral circulation and autoregulation is affected by the degree of prematurity and fetal hypoxia. Currently, the data on changes in postnatal cerebral blood flow indices in preterm and SGA neonates is limited.
Objective: To investigate the differences between cerebral hemodynamics between preterm (28 0/6- 34 6/7) small for gestational age (SGA) and appropriate for gestational age (AGA) neonates.
Methodology: In this prospective cohort study done in a tertiary care centre of South India in the year 2020-2021, we compared cerebral function parameters as assessed by doppler sonography between hemodynamically stable SGA (n = 57) and AGA neonates (n = 91) admitted to the NICU during the first 72 hours.
Results: Preterm SGA neonates have significantly lower pulsatility index (PI) and resistive index (RI) in middle cerebral artery on day 2 and day 3. On day 2, the median (IQR) PI was 1.05 (0.91-1.98) vs 1.26 (1.10-1.39), p=0.002 and mean ± SD RI of 0.67 ± 0.09 vs 0.71 ± 0.08, p=0.01 and on day 3 median (IQR) PI was 1.12 (1.01-1.32) vs 1.28 (1.10-1.51), p=0.05 and mean ± SD RI of 0.68 ± 0.08 vs 0.72 ± 0.10 (p = 0.01) in SGA and AGA neonates respectively.
Conclusion: SGA neonates have significantly lower indices of cerebral perfusion as seen by low PI and RI in MCA (middle cerebral artery) as compared to their AGA counterparts.