bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lived experience of long-term follow-up clinical care for haematopoietic stem cell recipients in England: A qualitative exploration.
Authors: Bell Blossom , Swainston Katherine 
Published: February 2023

Abstract

Purpose: Despite a haematopoietic stem cell transplant (HSCT) being a potentially curative treatment option for malignant and non-malignant disorders, patients may develop complex physical and psychological post-transplant complications. Consequently, transplant centres remain responsible for patients' life-long monitoring and screening practices. We sought to describe how HSCT survivors experience long-term follow-up (LTFU) monitoring clinics in England.
Method: A qualitative approach was adopted with data collected from written accounts. Seventeen transplant recipients were recruited from across England: the data was analysed using thematic analysis.
Results: Data analysis elicited four themes: transfer to LTFU care: “will there be a change in my care, or will appointments just become less frequent?”; Care Coordination: “it is good to know I am still in the system”; Relationship continuity: “a good knowledge of me, my health and what is important to me”; and Late-effects Screening: “there was not much information about what to expect or be aware of”.
Conclusions: HSCT survivors in England experience uncertainty and lack of information regarding the transfer from acute to long-term care and clinic screening practices. However, patients gain reassurance from remaining on a healthcare pathway and maintaining relationships with healthcare professionals. Implications for Cancer Survivors: HSCT recipients entering LTFU monitoring clinics are a growing population of cancer survivors. Understanding and acknowledging this cohort of patients' needs may inform the development of tailored support to help patients navigate the complicated healthcare pathway.
Nurture: A novel approach to PSS-rebound effect identification
Authors: Alfarisi Salman , Mitake Yuya , Tsutsui Yusuke , Wang Hanfei , Shimomura Yoshiki 
Published: February 2023

Abstract

Product-service system is a significant research subject related to business model innovation and sustainability. However, the Product-service system feature has affected consumption behaviour, affecting nurture. The authors identified an apparent knowledge gap in the prior literature concerning nurture in the Product-service system. This study examined that nurture should be a prominent issue in the Product-service system since certain features can significantly affect the achievement of set targets by generating a rebound effect. This study demonstrates that the business model system is complex, with interconnected solutions and issues. Solutions are not implemented in isolation. Therefore, each decision affects the system. This study employs feedback system thinking using system dynamics. To validate its findings against the actual situation, this study employs car-sharing as a case study. The findings of this study indicate that the variable of nurture is a significant indicator of profit growth but generates a deterioration in the environmental and social performance of Product-service system implementation, which leads to a rebound effect of the Product-service system.
Quality of Joint Examinations towards Preparing Students for Standard Seven Examinations in Tanzania
Authors: Rubeba Asia Mbwebwe , Kitula Paul Raphael 
Published: February 2023

Abstract

The major role of formative assessment is to give continuous feedback to teachers and learners on learning success for the purpose of improvement. This study was conducted to assess the quality of joint examinations administered in public primary schools for preparing students for standard seven examinations in Tanzania. Specifically, the study determined the extent to which joint examinations cover the contents in the syllabi, investigated whether such examinations are prepared by skilled teachers and investigated how joint examinations influence students’ preparations. Cross sectional design was adopted where standard seven teachers from primary schools in Moshi district were targeted. The study sample consisted of 50 teachers who were selected from 10 public primary schools in Moshi district. Questionnaires and interview schedules were used as tools for data collection and the collected data were analysed using descriptive and thematic analysis. The study found out that joint examinations have good coverage of the syllabi but their preparation does not involve experts in the field of educational assessment. Teachers believed that joint examinations increased students’ learning time thus making them better prepared for the final examinations. It was concluded that despite the observed limitations, if well prepared and managed, joint examinations can greatly enhance students’ performance in the primary education leaving examination. Therefore, the study recommends for all the bodies involved in the process of preparing, administering and evaluating joint examinations to take the process seriously.
Forecasting carbon dioxide emissions: application of a novel two-stage procedure based on machine learning models
Authors: Wang Chunzi , Li Moye , Yan Junpeng 
Published: February 2023

Abstract
Accurate forecast of carbon dioxide (CO2) emissions plays a significant role in China's carbon peaking and carbon neutrality policies. A novel two-stage forecast procedure based on support vector regression (SVR), random forest (RF), ridge regression (Ridge), and artificial neural network (ANN) is proposed and evaluated by comparing it with the single-stage forecast procedure. Nine independent variables’ data (study period: 1985–2020) are used to forecast the CO2 emissions in China. Our results reveal that, when the time gap, h increases from 1 to 8, the average root mean squared error (RMSE) and mean absolute error (MAE) of SVR–SVR, SVR–RF, SVR–Ridge, and SVR–ANN are almost uniformly lower than errors arising from their single-stage version, respectively. Among these two-stage models, SVR–ANN exhibits the lowest forecast errors, whereas SVR–RF admits the highest. The mean percentage decrease in forecast errors of SVR–SVR vs. SVR, SVR–RF vs. RF, SVR–Ridge vs. Ridge, and SVR–ANN vs. ANN are 36.06, 5.98, 43.05, and 14.81 for RMSE, and 36.06, 6.91, 43.27, and 15.35 for MAE. Our two-stage procedure is also suitable to forecast other variables, such as fossil fuel and renewable energy consumption.
Evaluation of the success of the hybrid wavelet-based ANFIS approach in the estimation of monthly stream flows of the Bitlis River, Turkey
Authors: Katipoğlu Okan Mert 
Published: February 2023

Abstract
This study aimed to predict monthly flows using an adaptive neuro-fuzzy inference system (ANFIS) and wavelet-ANFIS (W-ANFIS) and to determine the effect of wavelet transformation on the success of the machine learning model. For this purpose, the model inputs are divided into three subcomponents with Daubechies 10 mother wavelets. Subcomponents with the highest correlation were chosen as inputs. The most suitable models were selected by dividing the inputs into 3–7 sub-sets, using 11 different lagged input combinations, and testing various membership functions. In establishing the ANFIS model, 75% of the data were used for training and 25% for testing. The performance of ANFIS models was evaluated with root mean square error, Pearson correlation coefficient, determination coefficients, and Taylor diagram. A model with two sub-sets, a hybrid learning algorithm, a Gbellmf membership function, and 400 iterations was selected as the most suitable. It was concluded that the W-ANFIS model used with the wavelet transform method increased the success of the established ANFIS model. Moreover, it was suggested that the W-ANFIS hybrid machine learning model established in the study can be used effectively in similar climatic regions fed by snowmelt and dominated by a semi-arid climate.
Отношение к деньгам у старших подростков с разным уровнем личностной зрелости
Authors: Безгодова Светлана А. , Жарова Марина В. , Микляева Анастасия В. , Трапицын Сергей Ю. 
Published: February 2023

Введение. Обзор литературы, посвященной изучению закономерностей экономической социализации подростков, позволяет сформулировать предположение о том, что отношение подростков к деньгам (осознанность отношения к деньгам и уверенность в своих финансовых правах) опосредовано характеристиками их личностной зрелости. В статье впервые представлены результаты эмпирической проверки этой гипотезы. Методы. В исследовании приняли участие 1145 подростков в возрасте 13–17 лет (725 девочек и 418 мальчиков), не имеющих самостоятельных источников дохода. Сбор эмпирических данных осуществлялся с помощью «Шкалы самооценки зрелости личности» (А. В. Микляева) и «Шкалы отношения подростков к деньгам» (I. Beutler, C. Gudmunson). Результаты. Показатель финансовой осознанности увеличивается по мере взросления (F = 4,17 при р < 0,01), показатель финансовых прав претерпевает менее выраженные изменения (F = 1,34 при р > 0,05). Показатель финансовой осознанности достоверно выше в выборке девочек (F = 17,16 при р < 0,001). На протяжении всего старшего подросткового возраста показатель финансовых прав положительно связан с показателем регуляторной зрелости (F = 3,11 при р = 0,05), показатель финансовой осознанности положительно связан с показателем рефлексивной зрелости (F = 9,92 при р = 0,001) и отрицательно – с показателями регуляторной (F = 7,92 при р = 0,001) и когнитивной (F = 3,50 при р = 0,03) зрелости. Обсуждение результатов. Результаты интерпретируются в контексте социально-психологического подхода к становлению личности в процессе взросления. Делается вывод о том, что фиксируемое изменение отношения к деньгам в подростковом возрасте оказывается тесно сопряжено с оценкой подростками своего личностного потенциала, в частности – тех его сторон, которые позволяют принимать самостоятельные финансовые решения. Формулируются предложения для разработки программ мероприятий, направленных на содействие конструктивной экономической социализации подростков.
Согласование реальной и предпочитаемой организационной культуры современной региональной компании: ценностные предикторы
Authors: Хотинец Вера Ю. , Кожевникова Оксана В. , Баранова Наталья А. 
Published: February 2023

Введение. Новизна исследования заключается в том, что изучение организационной культуры осуществляется в связи с базовыми ценностями и целесообразной в современных условиях экономического развития и роста организацией деятельности персонала. Использована модель «конкурирующих ценностей», позволяющая определить направленность организационной культуры в двух основных измерениях, каждое из которых располагается между двумя полярными позициями: 1) свобода деятельности, динамичность / контроль, стабильность; 2) внешний фокус, дифференциация / внутренний фокус, интеграция. Методы. В исследовании приняли участие работники региональной компании, осуществляющей консультирование и обработку обращений, 90 человек в возрасте от 19 до 51 года. Использовались методики: выявления реального и предпочитаемого типов организационной культуры К. Камерона и Р. Куинна; измерения культурных ценностей Г. Хофстеде; акмеологического теста личностных ценностей А. В. Капцова. Для установления предикторов типов организационной культуры, целесообразных в современных условиях развития экономики, использовался множественный регрессионный анализ. Результаты. По результатам анализа профиля реальной организационной культуры в региональной компании установлено смещение акцента в сторону стабильности, порядка и контроля с преобладанием рыночной культуры при незначительном превышении иерархической. В качестве предпочитаемой работниками компании выступила клановая организационная культура, что объясняется сопротивлением социальных индивидов декларируемым ценностям культуры потребления и потребностью в групповой солидарности и социальной поддержке. Предикторами организационной культуры рыночного типа являются культурные ценности: большая дистанция власти, индивидуализм, маскулинность, наслаждение жизнью и личностные ценности семьи; адхократического типа – культурные ценности, актуализирующие субъектный контроль в инновационных достижениях. Обсуждение результатов. Сформулирован вывод о том, что менеджмент в современных региональных организациях, несмотря на вступление в рыночные отношения, продолжает полагаться на принципы контроля и стабильности – основу старой системы управления советского времени с подавляющим предпочтением поддержки и заботы со стороны руководства.
THE ACCEPTABILITY OF THE WE PASS WITH A AS COMPREHENSIVE APPROACH IN IMPLEMENTING COMPETENCY-BASED ASSESSMENT: A PRELIMINARY STUDY ON TEACHERS’ PERCEPTION
Authors: Suhoyo Yoyo , Rahayu Gandes Retno 
Published: February 2023

Background: A practical approach to assist teachers of medical and health profession education in designing and implementing competency-based assessment (CBA) is needed. This study aimed to investigate the acceptability of the method we developed, namely WE PASS with A as a comprehensive approach in designing and implementing CBA system.Methods: We invited medical and health profession teachers from various institutions in Indonesia who voluntarily join 4 times national workshops of the WE PASS with A. Workshop was conducted in two days (14 hours). Eighty-three teachers have participated in this study. Six closed questions using 5 Likert scales and 2 open questions was given at the end of each workshop.Results: Most teachers agreed that WE PASS with A approach covers all necessary principles for designing comprehensive assessment, helps them to understand better step by step, provides clear guideline, and can be learnt easily. However, most of them were doubt that their institutions have applied all steps in the WE PASS with A approach and can apply this approach. Teachers like the WE PASS with A approach because the approach is comprehensive, systematic, applicable, structured, simple, understood and remembered, measurable, ideal and accountable. Giving more examples, longer time to explain, more practice, socialization, and investigating the implementation were believed can improve the approach.Conclusion: The WE PASS with A can be accepted by the teachers of medical and health profession education in Indonesia. Future study needed to investigate the feasibility, acceptability, and impact of this approach.
A Simple Molecular Tool for the Assessment of Kidney Transplant Biopsies
Authors: de Nattes Tristan , Beadle Jack , Toulza Frederic , Candon Edvin , Ruminy Philippe , François Arnaud , Bertrand Dominique , Guerrot Dominique , Drieux Fanny , Roufosse Candice , Candon Sophie 
Published: February 2023

Background
The Banff Classification for Allograft Pathology recommendations for the diagnosis of kidney transplant rejection includes molecular assessment of the transplant biopsy. However, implementation of molecular tools in clinical practice is still limited, partly due to the required expertise and financial investment. The reverse transcriptase multiplex ligation-dependent probe amplification (RT-MLPA) assay is a simple, rapid, and inexpensive assay that permits simultaneous evaluation of a restricted gene panel using paraffin-embedded tissue blocks. The aim of this study was to develop and validate a RT-MLPA assay for diagnosis and classification of rejection.

Methods
A retrospective cohort of 220 kidney transplant biopsies from two centers, which included 52 antibody-mediated rejection, 51 T-cell–mediated rejection, and 117 no-rejection controls, was assessed. A 17-gene panel was identified on the basis of relevant pathophysiological pathways. A support vector machine classifier was developed. A subset of 109 biopsies was also assessed using the Nanostring Banff Human Organ Transplant panel to compare the two assays.

Results
The support vector machine classifier train and test accuracy scores were 0.84 and 0.83, respectively. In the test cohort, the F1 score for antibody-mediated rejection, T-cell–mediated rejection, and control were 0.88, 0.86, and 0.69, respectively. Using receiver-operating characteristic curves, the area under the curve for class predictions was 0.96, 0.89, and 0.91, respectively, with a weighted average at 0.94. Classifiers' performances were highest for antibody-mediated rejection diagnosis with 94% correct predictions, compared with 88% correct predictions for control biopsies and 60% for T-cell–mediated rejection biopsies. Gene expression levels assessed by RT-MLPA and Nanostring were correlated: r = 0.68, P < 0.001. Equivalent gene expression profiles were obtained with both assays in 81% of the samples.

Conclusions
The 17-gene panel RT-MLPA assay, developed here for formalin-fixed paraffin-embedded kidney transplant biopsies, classified kidney transplant rejection with an overall accurate prediction ratio of 0.83.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_04_10_CJN0000000000000100.mp3 and https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_11_02_Interview-with-Tris.mp3 (CJASN Trainee of the Year interview)
Frequency of Hypoglycemia Assessed by Continuous Glucose Monitoring in Advanced CKD
Authors: Ushiogi Yasuyuki , Kanehara Hideo , Kato Tamayo 
Published: February 2023

Background
Hypoglycemia represents a risk for serious morbidity. We evaluated the prevalence and risk factors of hypoglycemia by continuous glucose monitoring (CGM) in patients with CKD with or without diabetes.

Methods
In this cross-sectional study, outpatients with CKD stages G3–G5 (including hemodialysis) and type 2 diabetes without CKD were enrolled and underwent intermittently scanned CGM measurements for 7 days. The burden of CGM-measured hypoglycemia was assessed using the 7-day sum of area over the curve with glucose levels <70 mg/dl and the sum of time spent <54  mg/dl.

Results
A total of 366 participants (148 participants with CKD and diabetes, 115 with CKD and without diabetes, and 103 without CKD and with diabetes) were included. Glucose levels of <54  mg/dl were observed in 41% of participants with CKD and diabetes, 48% of participants with CKD and without diabetes, and 14% of participants with diabetes and without CKD. However, only two participants reported hypoglycemic symptoms during CGM measurements, which were confirmed and documented by capillary blood glucose measurements. Between-group differences of 7-day area over the curve (<70 mg/dl) were as follows: hemodialysis group versus CKD stage G4 and G5 groups, −0.25 min·mg/dl per hour (95% confidence interval [CI], −6.40 to −0.59) P<0.001; CKD stage G4 and G5 groups versus CKD stage G3 group, −0.08 min·mg/dl per hour (95% CI, −0.0 to −0.50) P=0.15; and CKD stage G3 group versus diabetes without CKD group, −0.14 min·mg/dl per hour (95% CI, −0.0 to −0.20) P=0.01. In addition, the subgroup analysis of the diabetic or nondiabetic and at daytime or nighttime showed that the 7-day area over the curve (<70 mg/dl) and time spent (<54 mg/dl) was larger with worse kidney function.

Conclusions
The lowering level of kidney function was strongly associated with the burden of hypoglycemia in patients with CKD.
Kidney Biopsy Findings in Patients with SARS-CoV-2 Infection or After COVID-19 Vaccination
Authors: de las Mercedes Noriega Maria , Husain-Syed Faeq , Wulf Sonia , Csala Benjamin , Krebs Christian F. , Jabs Wolfram J. , Zipfel Peter F. , Gröne Hermann-Josef , Wiech Thorsten ,   the CoV-Kidney Investigators*
Published: February 2023

Background
Emerging case series described a temporal association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and de novo or relapsing kidney diseases. We aimed to further understand vaccination- and coronavirus disease 2019 (COVID-19)–associated kidney diseases.

Methods
We present findings from native kidney biopsies of patients recently vaccinated against SARS-CoV-2 (n=27) and those with COVID-19 (n=15), reviewed at a single German center. Diagnoses were compared among all native kidney biopsies (n=10,206) obtained between the prepandemic (2019), pandemic (2020), and vaccination periods (2021) to determine whether there was an increase in kidney diseases in the observed periods.

Results
Biopsy indication was increased serum creatinine and/or new-onset proteinuria. Glomerulopathies (20/27, 74%) were more common than tubulointerstitial diseases in postvaccination patients, with necrotizing GN (8/27, 30%) and primary podocytopathies and other GN types (6/27, 22% each) the most common forms. Acute tubular injury was the most common kidney disease in patients with COVID-19, followed by thrombotic microangiopathy (TMA) and necrotizing GN. The postvaccination and COVID-19 infection groups had similar kidney function recovery rates (69% and 73%, respectively). Furthermore, the frequencies of necrotizing GN, pauci-immune GN, TMA, or primary podocytopathies at our center did not increase between 2019 and 2021.

Conclusions
We observed differences in entity frequencies between the SARS-CoV-2 vaccination or COVID-19 groups, with glomerulopathies being more common in patients after vaccination and tubulointerstitial diseases in patients with COVID-19. Cases of TMA were observed only in the COVID-19 group. We detected no increase in the frequency of necrotizing GN, TMA, or podocytopathies between 2019 and 2021.

Clinical Trial registry name and registration number:
Kidney Histopathology After COVID-19 and SARS-CoV-2 Vaccination, NCT05043168
Effectiveness of Three Doses of mRNA COVID-19 Vaccines in the Hemodialysis Population during the Omicron Period
Authors: Wing Sara , Thomas Doneal , Balamchi Shabnam , Ip Jane , Naylor Kyla , Dixon Stephanie N. , McArthur Eric , Kwong Jeffrey C. , Perl Jeffrey , Atiquzzaman Mohammad , Yeung Angie , Yau Kevin , Hladunewich Michelle A. , Leis Jerome A. , Levin Adeera , Blake Peter G. , Oliver Matthew J. 
Published: February 2023

Background
Coronavirus disease 2019 (COVID-19) vaccine effectiveness studies in the hemodialysis population have demonstrated that two doses of mRNA COVID-19 vaccines are effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe complications when Alpha and Delta were predominant variants of concern. Vaccine effectiveness after a third dose versus two doses for preventing SARS-CoV-2 infection and severe COVID-19 in the hemodialysis population against Omicron is not known.

Methods
We conducted a retrospective cohort study in Ontario, Canada, between December 1, 2021, and February 28, 2022, in the maintenance hemodialysis population who had received two versus three doses of mRNA COVID-19 vaccines. COVID-19 vaccination, SARS-CoV-2 infection, and related hospitalization and death were determined from provincial databases. The primary outcome was the first RT-PCR confirmed SARS-CoV-2 infection, and the secondary outcome was a SARS-CoV-2–related severe outcome, defined as either hospitalization or death.

Results
A total of 8457 individuals receiving in-center hemodialysis were included. At study initiation, 2334 (28%) individuals received three doses, which increased to 7468 (88%) individuals by the end of the study period. The adjusted hazard ratios (aHR) for SARS-CoV-2 infection (aHR, 0.58; 95% confidence interval [CI], 0.50 to 0.67) and severe outcomes (hospitalization or death) (aHR, 0.40; 95% CI, 0.28 to 0.56) were lower after three versus two doses of mRNA vaccine. Prior infection, independent of vaccine status, was associated with a lower risk of reinfection, with an aHR of 0.44 (95% CI, 0.27 to 0.73).

Conclusions
Three-dose mRNA COVID-19 vaccination was associated with lower incidence of SARS-CoV-2 infection and severe SARS-CoV-2–related outcomes during the Omicron period compared with two doses.