bluuebunny/crossref_metadata_2025_split huggingface dataset:
All dissolvable and transient plasmonic device enabled by nanoimprint lithography
Authors: Xiao Yibo , Cao Xinyi , Dong Qiao , Gao Li 
Published: April 2023

Abstract
Dissolvable and transient devices are important for environment-friendly disposal and information security. Similar to transient electronic devices, photonic devices use dissolvable metals such as magnesium and zinc to enable tunable plasmonic resonances. However, functional nanostructured substrates made of a common photoresist and a soft substrate are not dissolvable. In this study, we report the large-area, dissolvable polylactic-co-glycolic acid nanostructures formed by nanoimprint lithography and discuss the impact of the imprinting temperatures and ambient conditions on the formed nanostructures. The deposition of a thin layer of metal can yield a quasi-3D plasmonic device, and the choice of zinc metal can result in an all-dissolvable device in water over a few days. Consequently, the transmission spectra of these plasmonic devices could be tuned after placement in water. This strategy yields a truly transient nanophotonic device that can be degraded after performing its function for a specific period.
Optimization of energy parameters for laser-induced PDT of cervical tissues using numerical simulation and fluorescent monitoring
Authors: Alekseeva P M , Efendiev K T , Savelieva T A , Moskalev A S , Steiner R , Loschenov V B 
Published: April 2023

Abstract
The main problem in the photodynamic therapy (PDT) of tumors is insufficient light exposure to tissue or the appearance of undesirable surface effects. The reason is the irregular distribution of the absorbed light dose by depth. The influence of the spot diameter on the relative fluence rate in the near-surface layer of the cervical tissue was studied by Monte Carlo simulation. Photodynamic exposure with chlorine-type photosensitizer (PS) was carried out on the tissue model with laser 660 nm at the same power density with a change in spot diameter from 5 to 15 mm and radiation energy density from 100 to 300 J cm−2. The distributions of the fluorescence indices of the PS and the hemoglobin oxygenation degree by depth were obtained. The dependence of PS photobleaching on the energy density was established at the same power density and different spot diameters. The developed method increased the efficiency of PDT by delivering a sufficient energy density of laser radiation to the entire tumor tissue by depth without thermal damage, that allowed minimizing side effects and prevent possible growth and recurrence of the disease.
Computational ghost imaging through a dynamic scattering medium based on a convolutional neural network from simulation
Authors: Yu Zhan , Li Xinjia , Bai Xing , Wang Yujie , Chen Xingyu , Liu Yang , Sun Mingze , Zhou Xin 
Published: April 2023

Abstract
An imaging method through a dynamic scattering medium is presented based on computational ghost imaging (CGI) and a convolutional neural network (CNN). The CNN is adopted to improve CGI quality, and its training set is obtained from numerical simulation rather than actual experiments, which greatly reduces the workload. A concise mathematical model is given to reflect the absorption and scattering effects of the dynamic medium. By adding Gaussian white noise with different intensities to the detected light intensity sequence, the undulation caused by dynamic scatterer is simulated, and then the network is trained under these conditions. Compared to the dataset without adding noise, our proposed method leads to a better performance of the trained network in imaging through a dynamic scattering medium, not only for the simple binary objects, but also the complex grayscale ones. The effectiveness of this method has been verified in experiments of scattering medium rotated at different speeds.
Isomorphism between the Białynicki-Birula and the Landau-Peierls Fock space quantization of the electromagnetic field in position representation
Authors: Federico M , Jauslin H R 
Published: April 2023

Abstract
We first present a summary of the quantization of the electromagnetic field in position space representation, using two main approaches: the Landau-Peierls approach in the Coulomb gauge and the Białynicki-Birula (BB) approach, based on the Riemann–Silberstein vector. We describe both in a framework that starts with a classical Hamiltonian structure and builds the quantum model in a bosonic Fock space by a precisely defined principle of correspondence. We show that the two approaches are completely equivalent. This is formulated by showing that there is a unitary map between the Fock spaces that makes them isomorphic. Since all the physically measurable quantities can be expressed in terms of scalar products, this implies that the two quantizations lead to exactly the same physical properties. We show furthemore that the isomorphism is preserved in the time evolutions. To show the equivalence, we use the concepts of helicity and frequency operators. The combination of these two operators provides a formulation that allows one to make the link between these two methods of quantization in a precise way. We also show that the construction in the BB quantization that avoids the presence of negative eigenvalues in the Hamiltonian, in analogy with the one for the Dirac equation for electrons and positrons, can be performed through an alternative choice of the canonical variables for Maxwell’s equations.
Comprehensive studies on the universality of BKT transitions—machine-learning study, Monte Carlo simulation, and level-spectroscopy method
Authors: Otsuka Hiromi , Shiina Kenta , Okabe Yutaka 
Published: April 2023

Abstract
Comprehensive studies are made on the six-state clock universality of two models using several approaches. We apply the machine-learning technique of phase classification to the antiferromagnetic (AF) three-state Potts model on the square lattice with ferromagnetic next-nearest-neighbor (NNN) coupling and the triangular AF Ising model with anisotropic NNN coupling to study two Berezinskii–Kosterlitz–Thouless transitions. We also use the Monte Carlo simulation paying attention to the ratio of correlation functions of different distances for these two models. The obtained results are compared with those of the previous studies using the level-spectroscopy method. We directly show the six-state clock universality for totally different systems with the machine-learning study.
Child Survival and Annual Crop Yield Reductions in Rural Burkina Faso: Critical Windows of Vulnerability Around Early-Life Development
Authors: Belesova Kristine , Gasparrini Antonio , Wilkinson Paul , Sié Ali , Sauerborn Rainer 
Published: April 2023

Abstract
Populations that are reliant on subsistence farming are particularly vulnerable to climatic effects on crop yields. However, empirical evidence on the role of the timing of exposure to crop yield deficits in early-life development is limited. We examined the relationship between child survival and annual crop yield reductions at different stages of early-life development in a subsistence farming population in Burkina Faso. Using shared frailty Cox proportional hazards models adjusting for confounders, we analyzed 57,288 children under 5 years of age followed by the Nouna Health and Demographic Surveillance System (1994–2016) in relation to provincial food-crop yield levels experienced in 5 nonoverlapping time windows (12 months before conception, gestation, birth–age 5.9 months, ages 6.0 months–1.9 years, and ages 2.0–4.9 years) and their aggregates (birth–1.9 years, first 1,000 days from conception, and birth–4.9 years). Of the nonoverlapping windows, point estimates were largest for child survival related to food-crop yields for the time window of 6.0 months–1.9 years: The adjusted mortality hazard ratio was 1.10 (95% confidence interval: 1.03, 1.19) for a 90th-to-10th percentile yield reduction. These findings suggest that child survival in this setting is particularly vulnerable to cereal-crop yield reductions during the period of nonexclusive breastfeeding.
Quantitative model for genome-wide cyclic AMP receptor protein binding site identification and characteristic analysis
Authors: Chen Yigang , Lin Yang-Chi-Dung , Luo Yijun , Cai Xiaoxuan , Qiu Peng , Cui Shidong , Wang Zhe , Huang Hsi-Yuan , Huang Hsien-Da 
Published: April 2023

Abstract
Cyclic AMP receptor proteins (CRPs) are important transcription regulators in many species. The prediction of CRP-binding sites was mainly based on position-weighted matrixes (PWMs). Traditional prediction methods only considered known binding motifs, and their ability to discover inflexible binding patterns was limited. Thus, a novel CRP-binding site prediction model called CRPBSFinder was developed in this research, which combined the hidden Markov model, knowledge-based PWMs and structure-based binding affinity matrixes. We trained this model using validated CRP-binding data from Escherichia coli and evaluated it with computational and experimental methods. The result shows that the model not only can provide higher prediction performance than a classic method but also quantitatively indicates the binding affinity of transcription factor binding sites by prediction scores. The prediction result included not only the most knowns regulated genes but also 1089 novel CRP-regulated genes. The major regulatory roles of CRPs were divided into four classes: carbohydrate metabolism, organic acid metabolism, nitrogen compound metabolism and cellular transport. Several novel functions were also discovered, including heterocycle metabolic and response to stimulus. Based on the functional similarity of homologous CRPs, we applied the model to 35 other species. The prediction tool and the prediction results are online and are available at: https://awi.cuhk.edu.cn/∼CRPBSFinder.
Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis
Authors: Ashkir Z , Johnson S , Lewandowski A J , Hess A , Wicks E , Mahmod M , Myerson S , Ebbers T , Watkins H , Neubauer S , Carlhäll C J , Raman B 
Published: April 2023

Abstract

Aims
Hypertrophic cardiomyopathy (HCM) is characterized by hypercontractility and diastolic dysfunction, which alter blood flow haemodynamics and are linked with increased risk of adverse clinical events. Four-dimensional flow cardiac magnetic resonance (4D-flow CMR) enables comprehensive characterization of ventricular blood flow patterns. We characterized flow component changes in non-obstructive HCM and assessed their relationship with phenotypic severity and sudden cardiac death (SCD) risk.

Methods and results
Fifty-one participants (37 non-obstructive HCM and 14 matched controls) underwent 4D-flow CMR. Left-ventricular (LV) end-diastolic volume was separated into four components: direct flow (blood transiting the ventricle within one cycle), retained inflow (blood entering the ventricle and retained for one cycle), delayed ejection flow (retained ventricular blood ejected during systole), and residual volume (ventricular blood retained for &gt;two cycles). Flow component distribution and component end-diastolic kinetic energy/mL were estimated. HCM patients demonstrated greater direct flow proportions compared with controls (47.9 ± 9% vs. 39.4 ± 6%, P = 0.002), with reduction in other components. Direct flow proportions correlated with LV mass index (r = 0.40, P = 0.004), end-diastolic volume index (r = −0.40, P = 0.017), and SCD risk (r = 0.34, P = 0.039). In contrast to controls, in HCM, stroke volume decreased with increasing direct flow proportions, indicating diminished volumetric reserve. There was no difference in component end-diastolic kinetic energy/mL.

Conclusion
Non-obstructive HCM possesses a distinctive flow component distribution pattern characterised by greater direct flow proportions, and direct flow-stroke volume uncoupling indicative of diminished cardiac reserve. The correlation of direct flow proportion with phenotypic severity and SCD risk highlight its potential as a novel and sensitive haemodynamic measure of cardiovascular risk in HCM.
Searching for intralocus sexual conflicts in the three-spined stickleback (Gasterosteus aculeatus) genome
Authors: Sylvestre Florent , Mérot Claire , Normandeau Eric , Bernatchez Louis 
Published: April 2023

AbstractDifferences between sexes in trait fitness optima can generate intralocus sexual conflicts that have the potential to maintain genetic diversity through balancing selection. However, these differences are unlikely to be associated with strong selective coefficients and are challenging to detect. Additionally, recent studies have highlighted that duplications on sexual chromosomes can create artifactual signals of intralocus sexual conflicts. Thus, testing the relationship between intralocus sexual conflicts and balancing selection requires stringent filtering of duplicated regions, and dedicated methods to detect loci with low levels of intersex differentiation. In this study, we investigated intralocus sexual conflicts in the three-spined stickleback using whole-genome sequencing (mean coverage = 12×) of 50 females and 49 males from an anadromous population in the St. Lawrence River, Québec, Canada. After stringent filtering of duplications from the sex chromosomes, we compared three methods to detect intralocus sexual conflicts. We found only two genomic regions under potential intralocus sexual conflict that also showed signals of balancing selection. Overall, our results suggest that most intralocus sexual conflicts do not drive long-term balancing selection and are most likely transient.
Self-compatibility in yeast is selected for reproductive assurance not population-level compatibility
Authors: Nieuwenhuis Bart P S , Shraim Rasha , Al Ghaithi Hamed 
Published: April 2023

Abstract
In haploid species, sexual reproduction by selfing lacks the common benefits from recombination and is indistinguishable from asexual reproduction at the genetic level. Nevertheless, the evolution of self-compatibility, known as homothallism in organisms with mating types, has occurred hundreds of times in fungi. Two main hypotheses have been proposed for the evolution of homothallism. First, that homothallism offers reproductive assurance, which is especially important when species have an obligatory sexual phase in their lifecycle. Second, that homothallism is associated with population-level compatibility, increasing the chance of outbreeding. Here, we test these hypotheses using the fission yeast Schizosaccharomyces pombe, which is homothallic by mating-type switching, leveraging natural variation for switching efficiency in this species. Combining empirical tests with cellular automaton simulations, we show that homothallism by switching increases mating success of switching genotypes, but does not affect population-level compatibility. Experiments show that outcrossing is actually reduced under homothallism. This reduction in outcrossing is explained by our simulations, which show that due to local mating, gametes that mated through intraclonal selfing are no longer available for outcrossing. Our results suggest that the recurrent evolution of haploid self-compatibility is likely driven by selection for mating assurance, not to increase the potential for outcrossing.
Successful colonization of novel spruce hosts by European and North American spruce bark beetles can favour trans-Atlantic range expansion
Authors: Isitt Rylee , Økland Bjørn , Krokene Paal , Sweeney Jon , Heard Stephen B , Pureswaran Deepa S 
Published: April 2023

AbstractThe European spruce bark beetle Ips typographus and the North American spruce beetle Dendroctonus rufipennis cause high mortality of spruces on their native continents. Both species have been inadvertently transported beyond their native ranges. With similar climates and the presence of congeneric spruce hosts in Europe and North America, there is a risk that one or both bark beetle species become established into the non-native continent. There are many challenges that an introduced population of bark beetles would face, but an important prerequisite for establishment is the presence of suitable host trees. We tested the suitability of non-native versus native hosts by exposing cut bolts of Norway spruce (Picea abies), black spruce (Picea mariana) and white spruce (Picea glauca) to beetle attacks in the field in Norway and Canada. We quantified attack density, brood density and reproductive success of I. typographus and D. rufipennis in the three host species. We found that I. typographus attacked white and black spruce at comparable densities to its native host, Norway spruce, and with similar reproductive success in all three host species. In contrast, D. rufipennis strongly preferred to attack white spruce (a native host) but performed better in the novel Norway spruce host than it did in black spruce, a suboptimal native host. Our results suggest that I. typographus will find abundant and highly suitable hosts in North America, while D. rufipennis in Europe may experience reduced reproductive success in Norway spruce.
Comparative effects of benzoic acid and sodium benzoate in diets for nursery pigs on growth performance and acidification of digesta and urine
Authors: Choi Hyunjun , Chen Ying , Longo Flavio , Kim Sung Woo 
Published: April 2023

Abstract
The objective of this study was to evaluate the comparative effects of benzoic acid and sodium benzoate in feeds on digesta pH, urinary pH, and growth performance for nursery pigs. A total of 432 pigs (6.9 ± 0.9 kg BW) were assigned to eight treatments (6 pigs per pen, replication = 9) in a randomized complete block design with initial body weight (BW) as a block and fed for 41 d in three phases (7/17/17 d, respectively). Treatments were 1) a basal diet (NC), 2) NC + 0.25% bacitracin methylene disalicylate (antibiotic; bacitracin: 250 g/t feed; PC), 3) NC + 0.25% benzoic acid, 4) NC + 0.35% benzoic acid, 5) NC + 0.50% benzoic acid, 6) NC + 0.30% sodium benzoate, 7) NC + 0.40% sodium benzoate, and 8) NC + 0.60% sodium benzoate. Growth performance and fecal scores were measured for each phase. One gilt representing the median BW of each pen was euthanized to collect digesta from the stomach, proximal jejunum, distal jejunum, and cecum, and urine. The PC tended to improve average daily gain (ADG) in phase 1 (P = 0.052) and phase 2 (P = 0.093) as well as average daily feed intake (ADFI) in phase 2 (P = 0.052). Overall, increasing supplemental benzoic acid tended to have a quadratic effect on ADG (P = 0.094), but no difference in ADFI was observed. Increasing supplemental sodium benzoate showed a quadratic effect (P &lt; 0.05) on ADG and linearly increased (P &lt; 0.05) ADFI. Urinary pH linearly decreased (P &lt; 0.05) with increasing supplemental benzoic acid, but was not affected by supplemental sodium benzoate. Increasing supplemental benzoic acid or sodium benzoate linearly increased (P &lt; 0.05) benzoic acid content in digesta of the stomach. Increasing supplemental benzoic acid or sodium benzoate also linearly increased (P &lt; 0.05) urinary hippuric acid. However, the PC did not decrease urinary pH or increase urinary benzoic acid and hippuric acid. With slope-ratio assay using ADG and urinary hippuric acid as dependent variables and benzoic acid intake as an independent variable, the relative bioavailability of benzoic acid compared to sodium benzoate was not different. In conclusion, supplementation of benzoic acid and sodium benzoate could improve the growth performance of nursery pigs. The relative bioavailability of sodium benzoate to benzoic acid of nursery pigs did not differ based on BW gain and urinary hippuric acid.
Heterogeneous causal effects of neighbourhood policing in New York City with staggered adoption of the policy
Authors: Antonelli Joseph , Beck Brenden 
Published: April 2023

Abstract
In New York City, neighbourhood policing was adopted at the police precinct level over the years 2015–2018, and it is of interest to both (1) evaluate the impact of the policy, and (2) understand what types of communities are most impacted by the policy, raising questions of heterogeneous treatment effects. We develop novel statistical approaches that are robust to unmeasured confounding bias to study the causal effect of policies implemented at the community level. We find that neighbourhood policing decreases discretionary arrests in certain areas of the city, but has little effect on crime or racial disparities in arrest rates.
Global positioning system (GPS) and platform transmitter terminal (PTT) tags reveal fine-scale migratory movements of small birds: A review highlights further opportunities for hypothesis-driven research
Authors: Iverson Autumn R , Schaefer Jessica L B , Skalos Shannon M , Hawkins Carly E 
Published: April 2023

Abstract
Studying migration is critically important for understanding the full-annual cycle of migrating birds and aids in management and conservation. In recent years, global positioning system (GPS) and platform transmitting terminal (PTT) tags have become miniaturized, revolutionizing migration research by allowing for higher location accuracy and global coverage for smaller species. We reviewed 116 primary research papers from 2006 to 2021 that reported on GPS- or PTT-tagged small birds (&lt;500 g) during migration and assessed research aims, tag efficacy, ecological findings, and future opportunities. Reviewed papers covered 58 unique species (nearly half of which were shorebirds) and 65% of studies tagged birds at breeding grounds. Tags that did not require retrieval had higher success obtaining data, with PTT tags having the greatest success (85% of deployed tags had data). Of studies that reported tag load information, most (70%) reported tag loads ≥3% body mass, which is a potential concern given that 3% is considered the preferable upper limit. Most papers (69%) focused on presenting spatial information such as migratory routes, stopover sites, and habitat use, and only 33% of papers tested explicit hypotheses, demonstrating that we are in the early stages of understanding small bird migration at fine scales. Almost all tag deployments (93%) occurred in the northern hemisphere, most often in the United States (24%), indicating a deficiency in GPS and PTT research on small bird migration from the southern hemisphere. GPS and PTT tags have revealed new biological insights not possible with other technologies by providing fine-scale movement data and global coverage. There are exciting opportunities for researchers to move beyond descriptive spatial studies and explore hypothesis-driven migratory research, into topics such as intraspecific variation, carry-over effects, and climate-driven movements for irruptive species.