bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emicizumab prophylaxis in haemophilia A with inhibitors: Three years follow‐up from the UK Haemophilia Centre Doctors’ Organisation (UKHCDO)
Authors: Wall Caroline , Xiang Hua , Palmer Ben , Chalmers Elizabeth , Chowdary Pratima , Collins Peter W. , Fletcher Simon , Hall Georgina W. , Hart Daniel P. , Mathias Mary , Sartain Paul , Shapiro Susan , Stephensen David , Talks Kate , Hay Charles R.M. ,   the UK Haemophilia Centre Doctors’ Organisation (UKHCDO)
Published: February 2023

AbstractIntroductionThe UK National Haemophilia Database (NHD) collects data from all UK persons with haemophilia A with inhibitors (PwHA‐I). It is well‐placed to investigate patient selection, clinical outcomes, drug safety and other issues not addressed in clinical trials of emicizumab.AimsTo determine safety, bleeding outcomes and early effects on joint health of emicizumab prophylaxis in a large, unselected cohort using national registry and patient reported Haemtrack (HT) data between 01 January 2018 and 30 September 2021.MethodsProspectively collected bleeding outcomes were analysed in people with ≥6 months emicizumab HT data and compared with previous treatment if available. Change in paired Haemophilia Joint Health Scores (HJHS) were analysed in a subgroup. Adverse events (AEs) reports were collected and adjudicated centrally.ResultsThis analysis includes 117 PwHA‐I. Mean annualised bleeding rate (ABR) was .32 (95% CI, .18; .39) over a median 42 months treatment with emicizumab. Within‐person comparison (n = 74) demonstrated an 89% reduction in ABR after switching to emicizumab and an increase in zero treated bleed rate from 45 to 88% (p < .01). In a subgroup of 37 people, total HJHS improved in 36%, remained stable in 46% and deteriorated in 18%, with a median (IQR) within‐person change of −2.0 (−9, 1.5) (p = .04). Three arterial thrombotic events were reported, two possibly drug related. Other AEs were generally non‐severe and usually limited to early treatment, included cutaneous reactions (3.6%), headaches (1.4%), nausea (2.8%) and arthralgia (1.4%).ConclusionsEmicizumab prophylaxis is associated with sustained low bleeding rates and was generally well‐tolerated in people with haemophilia A and inhibitors.
Uniform pricing effect: The influence of uniform pricing on product value judgement and purchase intention
Authors: Zeng Shuaifan , Xu Xiaobing , Gu Yu , Zhang Jin 
Published: February 2023

AbstractUniform pricing, which is a pricing strategy that sets a unified price for all products in the store or all products in the same category, is becoming increasingly popular over the past decades. However, scarce attention has been paid to investigating its impact on consumer behaviour. This research investigates the influence of uniform pricing on product value judgements and purchase intentions. Four studies demonstrate that uniform pricing (vs. non‐uniform pricing) could induce stronger promotion perception, which leads to more positive product value judgements and purchase intentions. Moreover, price sensitivity and product involvement moderate this effect, and this effect only exists for high price‐sensitive consumers and low product involvement consumers.
How online reviews with different influencing factors affect the diffusion of new products
Authors: Sun Bing , Kang Min , Zhao Shunyao 
Published: February 2023

AbstractOnline reviews are becoming increasingly important for the diffusion of new products. Based on the content of online reviews on JD.com, the study utilizes the Latent Allocation model to identify the critical factors of interest to consumers and categorized them into two categories, namely, product quality and supporting service factors. Thereafter, we use the system generalized method of moments to analyse the dynamic model of the panel data and further study the relationship between online reviews and new product diffusion under the two types of factors. We further investigate how the interaction between the critical metrics of online reviews affects the diffusion of new products. The results indicate that as various factors are considered, online reviews have a significantly different impact on the diffusion of new products. Moreover, compared with supporting service factors, online reviews of product quality factors have a more significant impact. In addition, the interactions between online review metrics demonstrate complex characteristics, especially the volume and positive emotional tendency, which does not promote new product diffusion, as expected.
Expanding horizons of reconstructive microsurgery in Lebanon: Reconstruction of complex traumatic wounds with anterolateral thigh perforator flaps in paediatrics patients less than 10 years of age
Authors: Ibrahim Amir E. , Ghieh Fadi M. , Oneisi Ahmad K. , Atiyeh Bishara S. , Bassil Georges F. , Otayek Joeffroy N. , Kortbawi Rabih R. , Moucharafieh Ramzi S. 
Published: February 2023

AbstractPaediatric complex wounds pose a challenge to the reconstructive surgeon due to the intricacy of reconstructive options required. Developments in microsurgery and microsurgical technique have brought free tissue transfer ever closer to the comfort zone of the reconstructive surgeon for reconstruction of paediatric traumatic complex wounds. We present our experience of microsurgical reconstruction in Lebanon for complex traumatic wounds in paediatric patients under the age of 10 years using the free anterolateral thigh (ALT) flap. The ALT flap has proven its value as a safe, adaptable, and aesthetically acceptable reconstructive option in paediatric complex trauma.
SiCN ceramics with controllable carbon nanomaterials for electromagnetic absorption performance
Authors: Zhang Yuyu , Sun Jia , Wang Yuqi , Riedel Ralf , Fu Qiangang 
Published: February 2023

AbstractDifferent kinds of carbon nanomaterials, free carbon (Cfree), graphene, and N‐containing graphene (NG), in single‐source‐precursors‐derived SiCN ceramics, were in situ generated by modifying polysilazane with divinylbenzene, dopamine hydrochloride and melamine, respectively. Adjusting the carbon source brings phase structure and electromagnetic wave absorption (EMA) properties differences of SiCN/C ceramics. In situ Cfree enhances the EMA capacity of SiCN ceramics by improving their electrical conductivity of 9.2 × 10−4 S/cm. The electrical conductivity of SiCN ceramics with 2D graphene sheets balloons to 2.5 × 10−3 S/cm, causing poor impedance match thus leading to a worse EMA performance. In situ NG in SiCN ceramics has a low electrical conductivity of 5.6 × 10−8 S/cm, making for excellent impedance match. The corrugated NG boosts dielectric loss, interfacial, and dipole polarization. NG‐SiCN nanocomposites possess an outstanding EMA performance with RLmin of −61.08 dB and effective absorption bandwidth of 4.05 GHz, which are ∼2.4 times lower and ∼4 times higher than those of SiCN, respectively.
Mass fabrication of Li2TiO3–Li4SiO4 ceramic pebbles with high strength by facile centrifugal granulation method
Authors: Tan Guangfan , Hu Xin , Cai Liang , Xue Haifeng , Yang Xiuhong , Zhang Yingchun 
Published: February 2023

AbstractThe bi‐phase Li2TiO3–Li4SiO4 ceramic pebbles have been considered a promising breeder to realize the tritium self‐sustainment in the blanket. However, up to now, the reported ceramic pebbles have the disadvantages of low yield, poor crushing load, and loose internal structure, which cannot meet the practical application requirements. In this work, the Li2TiO3–Li4SiO4 ceramic pebbles with excellent mechanical properties were fabricated successfully via the centrifugal granulation method with the assistance of introducing a spray‐drying process, simulating particle trajectory by discrete element software and improving bonding interface between core and shell with ethylene glycol. The composition, microstructure, and inner structure of the Li2TiO3–Li4SiO4 ceramic pebbles were investigated, respectively, through X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, and X‐ray computed tomography (CT). It can be found that the employment of the ethylene glycol solution on the surface of Li2TiO3 can make the core and the shell combine well. Moreover, the effect of the rolling speed of the Li2TiO3–Li4SiO4 ceramic pebbles was investigated via discrete element method (EDEM) simulation and experiments. The experimental results displayed that the Li2TiO3–Li4SiO4 ceramic pebbles sintered at 1100°C for 2 h have a uniform diameter of 1 mm, a good sphericity of 0.97, and an excellent crushing load of 82.4 N, which are superior to those pebbles that obtained by using the traditional wet methods. Moreover, the CT results showed that the appropriate porosity of the core was 3.21% and of the shell was 10.73%. Therefore, the simple centrifugal granulation method can be applied to prepare the Li2TiO3–Li4SiO4 ceramic pebbles in a large scale and shed a light to investigate the relevant advanced biphasic tritium breeder materials in the future.
Advancing trauma‐informed care in intellectual and developmental disability services: A pilot study of a digital training with direct service providers
Authors: Keesler John M. , Purcell Alex , Thomas‐Giyer Jen 
Published: February 2023

AbstractBackgroundAs trauma‐informed care advances in the service delivery system for people with intellectual and developmental disabilities, additional resources are needed to foster staff development. This article describes the development and pilot evaluation of a digital training on trauma‐informed care among direct service providers (DSPs) in the disability service industry.MethodFollowing an AB design, a mixed methods approach was used to analyse the responses of 24 DSPs to an online survey at baseline and at follow‐up.ResultsThe training was associated with increased staff knowledge in some domains and greater alignment with trauma‐informed care. Staff expressed a strong likelihood of using trauma‐informed care in practice and identified organisational assets and barriers to implementation.ConclusionsDigital trainings can facilitate staff development and the advancement of trauma‐informed care. Although additional efforts are warranted, this study fills a gap in the literature regarding staff training and trauma‐informed care.
Risk and prognosis of secondary thoracic cancers after radiation therapy for esophageal cancer
Authors: Yi Hang , Li Shuofeng , Lin Yiwen , Li Feng , Wang Shuaibo , Jin Donghui , Lv Zhuoheng , Fu Li , Mao Yousheng 
Published: February 2023

AbstractBackground and AimRadiation therapy (RT) is a crucial modality for the local control of esophageal cancer (EC), but the effect of RT on the development of secondary thoracic malignancies is still unclear. This study aims to identify the association between RT for the treatment of primary EC and subsequent secondary thoracic cancer (STC).MethodsThe primary EC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Fine‐Gray competing risk regression and standardized incidence ratio (SIR) were used to evaluate the radiotherapy‐associated cancer risk. Overall survival (OS) was compared by Kaplan–Meier analysis.ResultsA total of 40 255 EC patients from the SEER database were identified, of which 17 055 patients (42.37%) did not receive radiotherapy (NRT) and 23 200 patients (57.63%) had been treated with RT. After 12 months of latency, 162 patients (0.95%) in the NRT group and 272 patients (1.17%) in the RT group developed STC. The incidences of the RT group were significantly higher than the NRT group. Patients who have primary EC were at an increased risk of developing STC (SIR = 1.79, 95% CI: 1.63–1.96). The SIR of STC was 1.37 (95% CI: 1.16–1.60) in the NRT group and 2.10 (95% CI: 1.87–2.34) in the RT group. The OS of STC patients in the RT group was significantly lower than the NRT group (P = 0.006).ConclusionThe RT for primary EC was associated with higher risks of developing STC than patients unexposed to radiotherapy. The EC patients treated with RT, especially young patients, require long‐term monitoring of the risk of STC.
Randomized controlled feasibility trial of swallow strength and skill training with surface electromyographic biofeedback in acute stroke patients with dysphagia
Authors: Benfield Jacqueline K. , Hedstrom Amanda , Everton Lisa F. , Bath Philip M. , England Timothy J. 
Published: February 2023

AbstractBackground & ObjectivesSwallow strength and skill training with surface electromyography (sEMG) biofeedback may improve dysphagia but little is known about the feasibility and efficacy of this intervention in acute stroke.MethodsWe conducted a randomized controlled feasibility study in acute stroke patients with dysphagia. Participants were randomized to either usual care or usual care plus swallow strength and skill training with sEMG biofeedback. Primary outcomes were feasibility and acceptability. Secondary measures included swallowing and clinical outcomes, safety and swallow physiology.ResultsTwenty‐seven patients (13 biofeedback, 14 control) with average age of 73.3 (SD 11.0) and National Institute of Health Stroke Scale (NIHSS) of 10.7 (5.1) were recruited 22.4 (9.5) days post stroke. About 84.6% of participants completed >80% of sessions; failed sessions were mainly due to participant availability, drowsiness or refusal. Sessions lasted for an average of 36.2 (7.4) min. Although 91.7% found the intervention comfortable with satisfactory administration time, frequency and time post stroke, 41.7% found it challenging. There were no treatment‐related serious adverse events. The biofeedback group had a lower Dysphagia Severity Rating Scale (DSRS) score at 2 weeks compared to control (3.2 vs. 4.3), but the difference did not reach statistical significance.ConclusionsSwallow strength and skill training with sEMG biofeedback appears feasible and acceptable to acute stroke patients with dysphagia. Preliminary data suggests it is safe and further research refining the intervention and investigating treatment dose and efficacy is warranted.
40Ar/39Arages ofL4,H5,EL6,and feldspathic ureilitic clasts from the Almahata Sitta polymict ureilite (asteroid 2008TC3)
Authors: Turrin Brent D. , Lindsay Fara , Delaney Jeremy S. , Park Jisun , Herzog Gregory F. , Swisher Carl , Goodrich Cyrena A. 
Published: February 2023

AbstractThe Almahata Sitta (AhS) meteorite consists of disaggregated clasts from the impact of the polymict asteroid 2008 TC3, including ureilitic (70%–80%) and diverse non‐ureilitic materials. We determined the40Ar/39Ar release patterns for 16 AhS samples (3–1500 μg) taken from three chondritic clasts, AhS 100 (L4), AhS 25 (H5), and MS‐D (EL6), as well as a clast of ureilitic trachyandesite MS‐MU‐011, also known as ALM‐A, which is probably a sample of the crust of the ureilite parent body (UPB). Based on our analyses, best estimates of the40Ar/39Ar ages (Ma) of the chondritic clasts are 4535 ± 10 (L4), 4537–4555 with a younger age preferred (H5), and 4513 ± 17 (EL6). The ages for the L4 and the H5 clasts are older than the most published40Ar/39Ar ages for L4 and H5 meteorites, respectively. The age for the EL6 clast is typical of older EL6 chondrites. These ages indicate times of argon closure ranging up to 50 Ma after the main constituents of the host breccia, that is, the ureilitic components of AhS, reached the >800°C blocking temperatures of pyroxene and olivine thermometers. We suggest that these ages record the times at which the clasts cooled to the Ar closure temperatures on their respective parent bodies. This interpretation is consistent with the recent proposal that the majority of xenolithic materials in polymict ureilites were implanted into regolith 40–60 Ma after calcium–aluminum‐rich inclusion and is consistent with the interpretation that 2008 TC3was a polymict ureilite. With allowance for its 10‐Ma uncertainty, the 4549‐Ma40Ar/39Ar age of ALM‐A is consistent with closure within a few Ma of the time recorded by its Pb/Pb age either on the UPB or as part of a rapidly cooling fragment. Plots of age versus cumulative39Ar release for 10 of 15 samples with ≥5 heating steps indicate minor losses of40Ar over the last 4.5 Ga. The other five such samples lost some40Ar at estimated times no earlier than 3800–4500 Ma bp. Clustering of ages in the low‐temperature data for these five samples suggests that an impact caused localized heating of the AhS progenitor ~2.7 Ga ago. In agreement with the published work, 10 estimates of cosmic‐ray exposure ages based on38Ar concentrations average 17 ± 5 Ma but may include some early irradiation.
Juvenile hormone regulates the photoperiodic plasticity of elytra coloration in the ladybird Harmonia axyridis
Authors: Li Jia‐Xu , Tian Zhong , Liu Xing‐Feng , Li Bei , An Hao‐Min , Brent Colin S. , Wang Jia‐Lu , Wang Xiao‐Ping , Liu Wen 
Published: February 2023

AbstractMany animals, including insects, exhibit plasticity of body colour in response to environmental changes. Varied expression of carotenoids, major cuticle pigments, significantly contributes to body colour flexibility. However, the molecular mechanisms by which environmental cues regulate carotenoid expression remain largely unknown. In this study, we used the ladybird Harmonia axyridis as a model to investigate the photoperiodic‐responsive plasticity of elytra coloration and its endocrine regulation. It was found that H. axyridis females under long‐day conditions develop elytra that are much redder than those under short‐day conditions, resulting from the differential accumulation of carotenoids. Exogenous hormone application and RNAi‐mediated gene knockdown indicate that carotenoid deposition was directed through the juvenile hormone (JH) receptor‐mediated canonical pathway. Moreover, we characterized an SR‐BI/CD36 (SCRB) gene SCRB10 as the carotenoid transporter responding to JH signalling and regulating the elytra coloration plasticity. Taken together, we propose that JH signalling transcriptionally regulates the carotenoid transporter gene for the photoperiodic coloration plasticity of elytra in the beetles, which reveals a novel role of the endocrine system in the regulation of carotenoid‐associated animal body coloration under environmental stimuli.
Effects of altered‐reality training on interocular disinhibition in amblyopia
Authors: Du Xinxin , Liu Lijuan , Dong Xue , Bao Min 
Published: February 2023

AbstractTraining of viewing an altered‐reality environment dichoptically has been found to reactivate human adult ocular dominance plasticity, allowing improvement of vision for amblyopia. One suspected mechanism for this training effect is ocular dominance rebalancing through interocular disinhibition. Here, we investigated whether the training modulated the neural responses reflecting interocular inhibition. Thirteen patients with amblyopia and 11 healthy controls participated in this study. Before and after six daily altered‐reality training sessions, participants watched flickering video stimuli with their steady‐state visually evoked potential (SSVEP) signals recorded simultaneously. We assessed the amplitude of SSVEP response at intermodulation frequencies, which was a potential neural indicator of interocular suppression. The results showed that training weakened the intermodulation response only in the amblyopic group, which was in agreement with the hypothesis that the training reduced interocular suppression specific to amblyopia. Moreover, even one month after the training ended, we could still observe this neural training effect. These findings provide preliminary neural evidence in support of the disinhibition account for treating amblyopia. We also explain these results with the ocular opponency model, which, to our knowledge, is the first time for this binocular rivalry model to be used in explaining long‐term ocular dominance plasticity.
Impact of conflict delisting and relisting on remaining products in retail stores: Sales gains across products categories and spillovers to nearby stores
Authors: Li H. Alice , Wan Xiang 
Published: February 2023

Disputes between retailers and manufacturers often result in the retailer delisting the manufacturer's products, which dramatically alters competition in the retail market. When rival products are temporarily delisted, the products remaining on retail shelves are expected to gain sales due to substitution. However, it is unclear how much sales gain of remaining products can be expected, how long the sales gain persists after the rival products are relisted, whether the sales gain varies in different product categories, and whether the sales gain spills over from the delisting retailer to nearby retailers. In this research, we exploit a natural experiment enabled by a dispute between a retail chain and a beverage manufacturer that resulted in a 4‐week delisting of all products by the manufacturer (the delisted manufacturer) across all of the retailer's U.S. stores. We focus on a manufacturer (the focal manufacturer) that directly competes with the delisted manufacturer and quantify the sales gain for this focal manufacturer during the delisting and after the relisting event. Interestingly, in a near‐duopoly market, the focal manufacturer only gained 12.2% of sales during the delisting. After the dispute was settled and competition restored, the focal manufacturer's sales fluctuated for about 2 months before returning to the pre‐delisting level. Additionally, we find a spillover in sales gain to nearby stores during the delisting, which was mainly to small‐box retail stores rather than big‐box stores. Moreover, at both delisting and nearby stores, we find the focal manufacturer's sugar‐sweetened, caffeinated, and star products gained sales during the event while other products did not. We check the robustness of our results with a machine learning nonparametric method, among a few other alternative methods, to measure the average treatment effects. Understanding the size and duration of these heterogeneous effects can help manufacturers and retailers better respond to changes in market competition and evaluate their delisting decisions.
Event‐related potentials associated with attentional networks evidence changes in executive and arousal vigilance
Authors: Luna Fernando Gabriel , Aguirre María Julieta , Martín‐Arévalo Elisa , Ibáñez Agustín , Lupiáñez Juan , Barttfeld Pablo 
Published: February 2023

AbstractAttention is regulated by three independent but interacting networks, that is, alerting, comprising phasic alertness and vigilance, orienting, and executive control. Previous studies analyzing event‐related potentials (ERPs) associated with attentional networks have focused on phasic alertness, orienting, and executive control, without an independent measure of vigilance. ERPs associated with vigilance have been instead measured in separate studies and via different tasks. The present study aimed to differentiate ERPs associated with attentional networks by simultaneously measuring vigilance along with phasic alertness, orienting, and executive control. Forty participants (34 women, age: M = 25.96; SD = 4.96) completed two sessions wherein the electroencephalogram was recorded while they completed the Attentional Networks Test for Interactions and Vigilance—executive and arousal components, a task that measures phasic alertness, orienting, and executive control along with executive (i.e., detection of infrequent critical signals) and arousal (i.e., sustaining a fast reaction to environmental stimuli) vigilance. ERPs previously associated with attentional networks were replicated here: (a) N1, P2, and contingent negative variation for phasic alertness; (b) P1, N1, and P3 for orienting; and (c) N2 and slow positivity for executive control. Importantly, different ERPs were associated with vigilance: while the executive vigilance decrement was associated with an increase in P3 and slow positivity across time‐on‐task, arousal vigilance loss was associated with reduced N1 and P2 amplitude. The present study shows that attentional networks can be described by different ERPs simultaneously observed in a single session, including independent measures of executive and arousal vigilance on its assessment.