bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirical Analysis on the Impact of Regional Allocation of Big Health
Industry on Industrial Economic Value Added
Authors: Chen Jun , Wu Huan , Luo Xiao 
Published: February 2023

Background:
With the development of economic society, people’s demand for big
health products is also growing. At the same time, the uncertainty of big healthy enterprises’ operations
is increasing, and the internal factors affecting enterprise performance are also increasing.

Methods:
Based on the data from 2010 to 2020 of 329 listed big health products companies in China,
this paper adopts a fixed effect regression model to empirically analyze the relationship among
marketing/ sale expenditure, R&D expenditure, and economic value added of big health enterprises.
The moderating effect of economic level and population size on the model is discussed by
grouping regression.

Results:
The results show that: In the long run, R&D investment and marketing/ sale investment
can significantly promote the growth of the overall value of China’s big health enterprises, and the
promotion effect lags.

Conclusions:
The big business enterprise of health investment in R&D and marketing/ sale of enterprise
development is affected by the business area location, such as R&D and marketing/ sale
spending in big cities can promote enterprise economic value added, and the small city marketing/
sale into obvious economic value added of the enterprise itself. Still, the R&D investment in the
small city has no significant correlation with enterprise economic value added.
Antioxidant Effects of Methanolic Extract of Quercus infectoria as a
Supplement against Oxidative Stress Induced by Sub-acute Exposure to
Arsenic; An in vivo Study
Authors: Sharififar Fariba , Pudineh Morref Mokarame , Karami-Mohajeri Somayyeh 
Published: February 2023

Background:
Exposure to arsenic through drinking water is a global health problem that causes
multisystem toxicity, mainly by inducing oxidative stress and impairing cellular energy.

Objective:
We aimed to evaluate the effect of Quercus infectoria gall extract (Qi) against oxidative stress
induced by sub acute exposure to arsenic.

Methods:
The plant galls were extracted with methanol and were used for the determination of total phenolic
content using Folin-Cio calteu reagent. Male Wistar rats were randomly divided into 8 groups of 6
animals and treated for 30 days. Negative and positive control groups received, respectively, normal saline
and sodium arsenite (5.5 mg/kg) by gavage. Treatment groups received three doses of Qi (200, 400,
and 600 mg/kg/day) by intraperitoneal injection 2 h. after oral administration of normal saline or sodium
arsenite (5.5 mg/kg) (As-Qi). After 30 days, all animals were anesthetized with ketamine/xylasine and 2
mL of blood was taken for measurement of total antioxidant capacity (TAC) using ferric reducing antioxidant
power (FRAP), lipid peroxidation (measurement of malondialdehyde (MDA)) and protein carbonylation
of plasma.

Results:
Total phenolic content of the plant was determined to be 5.78 ± 0.23 mg gallic acid equivalent/g
dried extract. The results of pharmacological studies indicated that in arsenic treated animals, a significant
decrease in TAC, increase in lipid peroxidation and protein carbonylation happens compared to control
group. Co-administration of Qi (600 mg/kg) with arsenic significantly increased TAC compared with
arsenic group (0.245 ± 0.007 versus 0.183 ± 0.027 for arsenic) (p < 0.05), while the serum MDA level
(1.880 ± 0.499 versus 2.795 ± 0.112 for arsenic) and protein carbonylation were decreased in this group
compared with arsenic treated animals (0.128 ± 0.007 versus 0.159 ± 0.009 for arsenic) (p <0.01). In
non-treated arsenic animals (NTAS), all three doses of Qi improved oxidative stress markers.

Conclusion:
Arsenic disrupt cellular antioxidant defense through overproduction of reactive oxygen species
(ROS) and the Qi galls are able to revert some of these oxidant activities of arsenic. Previous studies
have reported antioxidants in the plant and the present work can conclude that antioxidant effect of Qi is
useful against happened oxidative stress in arsenic treated animals.
INTEGRATION OF TECHNO-PEDAGOGICAL SKILLS IN TEACHER EDUCATION TO ENHANCE EMPLOYABILITY SKILLS AMONG PROSPECTIVE TEACHERS
Authors: Narayanan A. Lakshmi , Komalavalli T. . 
Published: February 2023

Presently the entire sector of the education undergoes in several aspects and particular in the pedagogical aspects. Traditional ways of imparting knowledge are being replaced with ICT integrated pedagogy. Techno-pedagogy has been the present way of providing education. There is a direct integration of the digital platform and tools to the offline traditional classroom. In techno-pedagogy the classroom is blended with usual physical and virtual mode of education. The teaching aids in traditional educational system are being replaced with digital tools and techniques to teach a concept.	Teacher education undergoes such new changes in the curriculum with the integration of technology leading to the improvement of the quality in teacher education. All the pedagogical practices in teacher education can be integrated with technology and this techno-pedagogy is used in the teacher education is an optimistic way.	Employability is the prime aim of any pattern and level of education. In teacher education too employability is very important in terms of the placement of the prospective teachers in schools. With the integration of the techno-pedagogy the employability skills of the prospective teachers could be enhanced. Teacher trainees who are exposed to techno-pedagogy have more chance of employability in best schools. In the light of these concepts, this article discusses on the importance of techno-pedagogy skills that can be developed among prospective teachers to increase their employability.
Characterizing e-Cigarette–Related Videos on TikTok: Observational Study
Authors: Xie Zidian , Xue Siyu , Gao Yankun , Li Dongmei 
Published: February 2023

Background
As a popular social networking platform for sharing short videos, TikTok has been widely used for sharing e-cigarettes or vaping-related videos, especially among the youth.

Objective
This study aims to characterize e-cigarette or vaping-related videos and their user engagement on TikTok through descriptive analysis.

Methods
From TikTok, a total of 417 short videos, posted between October 4, 2018, and February 27, 2021, were collected using e-cigarette or vaping-related hashtags. Two human coders independently hand-coded the video category and the attitude toward vaping (provaping or antivaping) for each vaping-related video. The social media user engagement measures (eg, the comment count, like count, and share count) for each video category were compared within provaping and antivaping groups. The user accounts posting these videos were also characterized.

Results
Among 417 vaping-related TikTok videos, 387 (92.8%) were provaping, and 30 (7.2%) were antivaping videos. Among provaping TikTok videos, the most popular category is vaping tricks (n=107, 27.65%), followed by advertisement (n=85, 21.95%), customization (n=75, 19.38%), TikTok trend (n=70, 18.09%), others (n=44, 11.37%), and education (n=6, 1.55%). By comparison, videos showing the TikTok trend had significantly higher user engagement (like count per video) than other provaping videos. Antivaping videos included 15 (50%) videos with the TikTok trend, 10 (33.33%) videos on education, and 5 (16.67%) videos about others. Videos with education have a significantly lower number of likes than other antivaping videos. Most TikTok users posting vaping-related videos are personal accounts (119/203, 58.62%).

Conclusions
Vaping-related TikTok videos are dominated by provaping videos focusing on vaping tricks, advertisement, customization, and TikTok trend. Videos with the TikTok trend have higher user engagement than other video categories. Our findings provide important information on vaping-related videos shared on TikTok and their user engagement levels, which might provide valuable guidance on future policy making, such as possible restrictions on provaping videos posted on TikTok, as well as how to effectively communicate with the public about the potential health risks of vaping.
A Study on the Risk Factors associated with Stroke in young adults and its Management Practices
Authors: Amaravadi Divya , Malavika Bijjaram , Suman Gurnoor , Jajapur Shresta , Sneha Rakham 
Published: February 2023

The various risk factors causing premature stroke and cardiovascular diseases in young adults and their management are increasing problems in both developed and developing countries. Cardiovascular diseases include heart conditions that involve diseased vessels, structural problems, and blood clots. This is a prospective observational study which was conducted for 6 months in the general medicine department of Gandhi Hospital, Hyderabad. The study was initiated after the approval by Institutional Ethical Committee. During the study period a total number of 80 cases were collected. Out of these cases (55 cases, 69%) were of ischemic stroke and (25 cases, 31%) of hemorrhagic stroke. It was observed that males were more prone to strokes and females are more prone to cardiovascular diseases. The most common risk factor associated with stroke was hypertension. The age group of 41–50 years was mostly affected by stroke and cardiovascular diseases. Therefore, from our study we observe that timely treatment and patient counselling on disease, disease management and medications are important parameters for better patient care and improving quality of life.
Keywords: Stroke, cardiovascular diseases, hypertension.
Formulation and Characterization of Montelukast Sodium Mouth Dissolving Film Using Cress Seed Mucilage
Authors: Wadher Kamlesh J. , Kubde Charvi J. , Malkote Swati D. , Thakre Manasi S. , Shelote Chetna J. , Umekar Milind J. 
Published: February 2023

There is a rising interest in the development of orodispersible films (ODFs) as an alternative to fast dissolving tablets which is attributed to their faster dissolution rate, higher durability, and better patient compliance. Owing to its rheological and also various functional properties, many researchers tried to discover some of the pharmaceutical applications of L. sativum in the development of various dosage forms, in addition to its therapeutic studies, such as binding, dissolving, gelling and sustained release dosage form. The fast-dissolving oral film of the Montelukast sodium by using Cress seed mucilage (CSM) and HPMC (15cps) is prepared by solvent casting method. The fast-dissolving oral film evaluated for folding endurance, surface pH, in-vitro disintegration time, drug content and in-vitro drug release. The physical appearance and folding endurance properties were found to be reasonably good and electron microscopy shows that films are clear, colorless with smooth surface.The drug content of all the films was in the range suggesting that drug was uniformly dispersed throughout all films. The present study was an attempt to develop and evaluate an oral fast dissolving drug delivery system using cress seed mucilage as a film former.
Keywords: Orodispersible film, Montelukast sodium, Cress seed mucilage, HPMC
Nanostructured Lipid Carriers of Eperisone Hydrochloride using Quality By Design Approach
Authors: Bagde Shapali , Mamidi Hemanth Kumar 
Published: February 2023

Objective: The current work involves formulation development of nanostructured lipid carrier (NLC) of eperisone hydrochloride (EPE) using quality by design (QbD) approach.
Materials and Methods: Initial screening of solid and liquid lipids was performed based on the Hansen solubility parameters of EPE and the lipids and later confirmed using saturation solubility studies. The optimum formulation was identified using three-squared randomized full factorial design. High shear homogenization coupled with ultrasonication was used to prepare the NLCs. The effect of the independent variables on the dependent variables was analyzed using response surface graphs and ANOVA. The optimized formulation is characterized for mean particle size, zeta potential, entrapment efficiency, in vitro drug release and subjected to stability testing.
Results and Discussion: Precirol® ATO 5, CapryolTM 90, and Pluronic® F127 are found to be ideal solid lipid, liquid lipid and surfactant respectively based on the initial screening. Amount of lipid mixture (X1) and the amount of surfactant (X2) were selected as independent variables and the entrapment efficiency (Y1), mean particle size (Y2) and zeta potential (Y3) were selected as dependent variables. The optimized NLC formulation has mean particle size of 175 nm, zeta potential -24.4 mV and entrapment efficiency of 78.64%. The in vitro drug release data suggested that the drug release follows Quasi-Fickian diffusion. The stability data showed that the NLCs are stable up to 3 months at refrigerated conditions.
Conclusions: The Hansen solubility parameter approach coupled with QbD is a powerful tool for formulation of sustained release NLCs of highly soluble poorly soluble drugs.
Keywords: Nanostructured lipid carrier, Solubility Parameters, Nanoparticles, Lipid based drug delivery, Quality by Design
Company's Financial Performance Before And After An Initial Public Offering: IPO At IDX In 2018
Authors: Telambanua Saraswati , Kurniasih Augustina 
Published: February 2023

The research aims to analyze differences in a company's financial performance before and after an Initial Public Offering (IPO). The research period is one year before and one year after the IPO. The population of this research is a company that conducted an IPO and listed on the Indonesia Stock Exchange in 2018 which amounted to 55 companies. Sample withdrawal uses purposive sampling method and based on predetermined criteria samples obtained as many as 50 companies. The analysis method used is a different Wilcoxon Signed Rank Test. The results showed significant differences in liquidity performance (current ratio), solvency (debt to equity ratio), profitability (return on equity), and activity (total assets turnover) before and after the IPO. Keywords: Initial Public Offering (IPO); liquidity; solvablity; profitability; activity.
Examining The Effect of Theory of Planned Behavior on Individual Investment Intention in The Indonesia Stock Exchange, Moderated by Herding Behavior and Risk Propensity
Authors: Bertuah Eka , Oppusunggu Hotman Dufeb Halomoan 
Published: February 2023

There are several products or instruments traded on the Indonesia Stock Exchange, that is Stocks, Bonds, Mutual Funds, Exchange Traded Funds (ETFs), and Derivatives, with stocks being the most popular instrument right now. The benefits of the existence of the capital market for investors are that it provides an opportunity for the public to have a healthy company that has good prospects in the future, and is an alternative investment beside gold and properties that provides potential profits with calculated risks (Kurniawan, 2019).Objectives: This study aims to determine the effect of the construct variable of the Theory of Planned Behavior on Investment Intention, and the role of Investment Intention as a mediating variable that connects these variables after being moderated by Risk Propensity and Herding Behavior on Investment Behavior of individual investors in IndonesiaMethodology: This study uses primary data which data was collected by distributing online questionnaires via google form. This research was conducted from January to March 2022, from a sample of individual investors from some big islands in Indonesia (Java, North Sumatra, South Sulawesi, Kalimantan). To determine the sample, this study uses the Slovin formula with probability sampling technique - simple random and a total of 525 respondents were collected, but those who met the predetermined sample criteria were 468 respondents. The data analysis that is used is the path analysis Structural Equation Model (SEM).Finding: Herding behavior and Risk Propensity do not strengthen Investment Intention among individual investors towards Investment Behavior and can be a subject for further study.Conclusion: The results of this study is only that Product Involvement of Theory of Planned Behavior variables can positively influence Investment Intention. Furthermore, Investment Intention can mediate this variable on Investment Behavior, although not strengthened by the influence of Risk Propensity and Herding Behavior
Trust is felt to be a Good Trigger in Marketing and Green Products in Generating Purchase Interest
Authors: Rasmen Adi I Nyoman , Mulyadi Made , Wirsa I Nengah , Astawa I Nengah Dasi , Setini Made 
Published: February 2023

Objective: This research was conducted with the aim of knowing the mediating role of trust in green products regarding the relationship between green product marketing awareness and product innovation on the purchase intention of environmentally friendly products.Methodology: This research is a quantitative research with the object of research are informants who already know as recycled fashion products, environmentally friendly drinking places, tissues, food containers and obtained 300 population data from distributing this questionnaire. The research instrument was distributed using a Google form. Using random sampling technique obtained 100 participants who already represent the representativeness of the data, analyzed by structural equation analysis (SEM) using the Smart PLS applicationResults: The findings of the study indicate that a direct relationship between green marketing awareness and product innovation has a positive influence on product purchase intentions. The direct relationship of trust felt by consumers has a positive influence on product purchase intentions. Mediating role Trust in products is able to mediate in awareness of green product marketing and product innovation on product purchase intentions. This means that the trust of customers must always be maintained in terms of the marketing we do and the products provided. Conclusion: Customers' trust in products that care about the environment that does not damage the environment is realized by a green marketing system so that this becomes a driving force for customers' buying intentions.
The Effect of Learning Organization, Work Engagement, Work Motivation, and Work Stress on Innovative Work Behavior: Work Motivation and Work Stress as Mediation and Moderation
Authors: Rajak Adnan , Soleman Rusman 
Published: February 2023

Objective: This study uses a quantitative approach or post-positivism, which is looking at the influence between variables. Therefore, the main problems in this study are: Does learning organization, work engagement, work motivation, and work stress affect innovative work behavior, how is the learning organization, and work stress on work engagement, how learning organization affects work motivation, how work motivation and work engagement mediate the relationship between learning organization and Innovative Work Behavior, and the relationship between work stress and Innovative Work Behavior, and how work engagement moderates the relationship between work engagement and Innovative Work Behavior and the relationship between learning organization and Innovative Work Behavior. Methodology: The analytical model used are Structural Equation Modeling and SMART PLS (Partial Least Square) as tools for the statistical test. Data collection tools used are questionnaires and interviews, and the number of respondents was 84 civil servants. Finding: Based on the results of hypothesis testing using Smart PLS, it shows that, H1, H2, H4, and H6 are acceptable, because the t table value is greater than the calculated t value, or has an alpha (α) value smaller than 5%. Whereas H3, H5, and H7 cannot be accepted (rejected), because the value is greater than 5%.Conclusion: The results showed that: (1) Learning organization had a positive and significant effect on Innovative Work Behavior, and work motivation but had no effect on work engagement, (2) Work engagement has an effect on Innovative Work Behavior), (3) Work motivation has no effect on Innovative Work Behavior, (4) Work stress has a positive and significant effect on Innovative Work Behavior but has no effect on work engagement, (5) Work motivation fully mediates the relationship between learning organization and Innovative Work Behavior, (6) Work engagement fully mediates the relationship/influence of learning organization and work stress on Innovative Work Behavior, and (7) Work motivation does not moderate the relationship or influence of learning organization and work engagement on Innovative Work Behavior.
Effects of hyperbaric oxygen therapy on clinical and economic outcomes in patients with deep second-degree burns
Authors:   Eskişehir Osmangazi University, Department of Gastroenterological Surgery, Eskişehir, Turkey, Özdemir Ümit , Akin Merve ,   Ankara City Hospital, Department of General Surgery, Ankara, Turkey, Sözen İsa ,   Süleyman Demirel University, Department of General Surgery, Isparata, Turkey, Erkent Murathan Erkent ,   Baskent University, School Of Medicine, Department of General Surgery, Ankara, Turkey, Tatar Selçuk ,   Ankara Gaziler Physical Therapy and Rehabilitation Education and Research Hospital, Underwater Medicine and Hyperbaric Medicine, Yasti Ahmet Çinar ,   Health Sciences University, Department of General Surgery, Ankara City Hospital, Burn Treatment Center
Published: February 2023

Introduction: Deep second-degree burn injuries are the most challenging situations for the burn surgeon in the treatment of adult cases. While waiting for spontaneous closure increases the risk of hypertrophic scar and keloid, early excision and grafting pose the risk of donor site wound and permanent color differences. Unlike many studies in the literature, the current study was planned in a way to minimize factors other than burn wounds to investigate the effect of adding hyperbaric oxygen (HBO2) therapy to conventional treatment in deep second-degree burn wounds. Material and Method: This prospective observational study included patients with burn injuries who underwent conventional treatment alone and those who underwent conventional plus HBO2 treatment performed by a single experienced surgeon and who met the study criteria. Results: Thirty-eight patients completed the study. Mean burned total body surface area (TBSA) was. 9.22 Å}3 43% (range 5% to 20%). There was no difference between the two groups in terms of age, burned TBSA, and burn etiology. The need for surgery and grafting was lower in patients who received HBO2 in addition to conventional treatment (p=0.003 and p=0.03, respectively). The patients in the HBO2 group had a shorter hospital stay, and their wounds epithelialized in a shorter time (p=0.169 and p<0.001, respectively). They also had a higher satisfaction level and lower treatment cost (p=0.03 and p=0.36, respectively). Discussion: The results of this prospective study, in which co-factors were eliminated, showed that adding HBO2 to the conventional treatment of deep second-degree burns had a significant positive effect on patient outcomes, as well as reducing treatment costs.