bluuebunny/crossref_metadata_2025_split huggingface dataset:
AÇÕES JUDICIAIS RELACIONADAS A MEDICAMENTOS EM JOÃO PESSOA, PB, BRASIL
Authors: Pacheco Larissa Figueiredo , Pereira Lailla Yasmin , Freitas Gabriel Rodrigues Martins de , Sousa Rênia Glauciene da Silva , Silva João Marcos de Araujo da , Carvalho Bruna Carla Cordeiro de 
Published: July 2023

No arcabouço do Sistema Único de Saúde existem diversos dispositivos a fim de garantir a integralidade terapêutica, destacando-se a existência de políticas públicas de saúde de acesso a medicamentos, o seu uso racional, a sua segurança, a sua efetividade e qualidade, b em como o seu financiamento. Todavia, em algumas situações o acesso a medicamentos não é assegurado plenamente para determinados tratamentos menos frequentes ou mais onerosos, e com intuito de garantir o direito à saúde, mecanismos judiciais são cada vez mais utilizados pela população. O objetivo deste trabalho foi analisar as ações judiciais de medicamentos impetradas contra o município de João Pessoa, PB (2010 a 2020). Foram analisados os arquivos impressos, contabilizando 1.273 ações judiciais disponibilizados pela Secretaria Municipal de Saúde. Estes dados foram organizados explorando as variáveis: temporalidade da solicitação judicial, existência ou não de pedido de tutela, medicamentos solicitados, descrição das características farmacêuticas, sexo dos solicitantes e origem do atendimento médico. O custo estimado das ações no período estudado, tomando por base apenas o custo dos medicamentos, a partir da tabela da Câmara de Regulação do Mercado de Medicamentos (CMED/Anvisa), foi de R$41.948.469,44, sendo o ano de 2017 aquele com maior dispêndio. Os medicamentos mais judicializados foram: Lucentis® (Ranibizumabe), Clexane® (Enoxaparina Sódica) e Xarelto® (Rivaroxabana), enquanto os mais onerosos foram: Spiranza®(Nusinersena), Imbruvica®(Ibrutinibe) e Ilaris®(Canaquinumabe). A demanda por acesso a medicamentos, pela via judicial, onera o aporte financeiro destinado à assistência farmacêutica municipal, onde os gastos tendem a elevar-se pela imprevisibilidade de programar a aquisição, impactando negativamente a saúde pública do município estudado. Há de se criar mecanismos a fim de auxiliar o Poder Judiciário a tomar decisões que envolvam o acesso a medicamentos.
DETECCIÓN DE LAS PRESCRIPCIONES POTENCIALMENTE INAPROPIADAS SEGÚN LOS CRITERIOS STOPP/START EN PACIENTES AMBULATORIOS DE UN HOSPITAL DE LA SEGURIDAD SOCIAL
Authors: Acosta Recalde Patricia Guadalupe , Maidana de Larroza Gladys Mabel , Maciel de Segovia Olga Yolanda , Lugo Rodriguez Gladys Beatriz , Samaniego Silva Lourdes Raquel 
Published: July 2023

A medida que envejecemos se van produciendo cambios estructurales y funcionales de los órganos, proceso asociado a múltiples comorbilidades, que requieren un tratamiento continuo y uso de múltiples medicamentos. La prescripción inapropiada en adultos mayores es una de las principales causas de reacciones adversas a medicamentos (RAM), lo que se asocia a un aumento de la morbimortalidad y el uso de los recursos en salud. El presente estudio tuvo como objetivo establecer la frecuencia de prescripciones potencialmente inapropiadas (PPI) mediante los criterios STOPP/START en pacientes adultos mayores del servicio de consulta ambulatoria de un Hospital de la Seguridad Social, mediante un estudio observacional, descriptivo, transversal y retrospectivo durante el primer cuatrimestre del 2021. Se analizaron 354 prescripciones de pacientes ambulatorios adultos mayores (65 años y más), de ambos sexos, con recolección de datos registrados en el Sistema Integrado Hospitalario (SIH). Se consideraron variables demográficas, frecuencia de PPI según criterios STOPP/START, donde la población de estudio en su mayoría fueron mujeres (61,6%) con una edad media de 74 años (DE=7,06). Del total de pacientes cuyas prescripciones formaron parte del estudio, el 57,06% (IC95% 57,14-56,97) presentó por lo menos 1 criterio STOPP o START. Los criterios aplicados son una herramienta de utilidad en la detección de los posibles problemas relacionados con los medicamentos en la prescripción, que al utilizarse en la práctica clínica mejoran la seguridad de los pacientes adultos mayores en su tratamiento farmacológico.
Treatment of patients with caudal regression syndrome: a systematic review of the literature
Authors: Sergeenko O. M. , Shchurova E. N. , Dolganova T. I. , Arestova Yu. S. , Saifutdinov M. S. 
Published: July 2023

Objective. To analyze and summarize the data of modern literature on the issues of surgical treatment and natural course of the spine and spinal cord pathology in patients with various types of caudal regression syndrome (CRS).Material and Methods. A systematic review of the literature on the issue of treatment of the spine and spinal cord pathology in patients with CRS was performed. Selection criteria were: articles for the period 2002–2022, original studies of populations/patients with various forms of CRS with a description of treatment methods and long-term results of treatment or observation. A total of 28 articles on the treatment of various forms of CRS with the described results of treatment of 212 patients were analyzed: 29 patients with CRS in combination with open neural tube defects and 183 patients with closed forms of CRS. Evaluation criteria included number of patients, gender, type of spinal cord pathology, type of sacral agenesis, presence of the spine and lower extremities deformities, concomitant pathology, operations performed and their complications, and results.Results. The studied patients underwent the following surgeries on the spine and spinal cord: untethering of the spinal cord, correction and stabilization surgeries on the spine, plasty of the spinal cord herniation, plasty of the terminal meningocele, and removal of the presacarial volumetric mass. The greatest number of complications occurred after operations on the spine and sacrum. The majority of patients (67 %) with sacral agenesis by the end of the follow-up period (average 14 years) walked independently or with the help of devices, and a minority of them (33 %) could not walk. More than half of patients with CRS (67 %) had a neurogenic bladder, urinary incontinence, or suffered from a chronic urinary tract infection. Fecal incontinence and constipation were less common (46 %).Conclusions. Patients with CRS have a good potential for improvement/recovery of walking and pelvic organ dysfunction. This is extremely important to timely carry out multimodality treatment of patients with CRS who have neurosurgical, orthopedic, urogenital and colorectal problems in CRS, and to start early motor rehabilitation and physiotherapy.
Zygmunt Ziembiński’s concept of the legal norm from a structuralist perspective
Authors: Bator Andrzej 
Published: July 2023

In the article I present the concept of the legal norm of conduct proposed by Zygmunt Ziembiński, situating it in the context of the structuralist research attitude – a methodological approach dominant in the Polish theory of law in the period when this key element of Ziembiński’s theory of law was created and shaped (the 1970s and 1980s). I illustrate individual fragments of the presented concept with selected quotations that are representative of the structuralist research approach. In my view, structuralism makes it possible to understand both the overwhelming influence ofZiembiński’s concept of the norm on the Polish legal theory of the second half of the twentieth century, as well as to explain the causes of the controversies that this concept provoked in some representatives of Polish jurisprudence. I also draw attention to the evolution of the concept in question, including the weakening of its structuralist overtones in the last years of the Professor’s scientific work. An example that exemplifies this tendency is the concept of competence norm.
Statistical analysis, modeling and multi-objective optimization of parameters intermittent turning process of AISI D3
Authors: Fethi Khelfaoui  , M. A. Yallese  , N. Ouelaa  , S. Chihaoui  , S. Belhadi  
Published: July 2023

Intermittent machining is characterized by its complex and irregular context. This intermittency causes machining to occur under difficult conditions that greatly influence the technological performance parameters. The aim of the present work is to evaluate the effects of input parameters, cutting speed, Vc, depth of cut, ap, tool nose radius, r and feed rate, f, on surface roughness, Ra, tangential cutting force, Fz, motor power consumption, Pm, cutting power, Pc and material removal rate (MRR), during intermittent turning (IT) of AISI D3 tool steel. Machining was performed with a triple CVD coated carbide tool (AI2O3/TiC/TiCN) by adopting a Taguchi L9 (3^4) experimental design. The ANOVA and RSM methods were used to analyze the effects of cutting factors on the outputs parameters resulting in statistical prediction models. In addition, a multi-objective optimization of the cutting conditions exploiting the desirability function (DF) was done according to four cases of relative importance corresponding to different industrial contexts. Furthermore, the grey relational analysis (GRA) method was applied and compared with the DF method. The results show that the optimal regime found by the DF method, (r =1.6mm, Vc= 240 m/min, f = 0.084 mm/rev and ap = 0.64 mm), favors Ra and MRR. On the other hand, for the GRA method, the combination of (r = 0.4 mm, Vc = 240 m/min f = 0.08 mm/rev and ap = 0.3 mm) favors the minimization of Fz, Pm and Pc. This work presents an originality because the results found are very useful in the field of optimization for a better control of the process IT.
Sustainability Reporting, Foreign Ownership, Firm Value as a Function of Investment Opportunity Set
Authors: Hasanah Vanisa Nur , Nuraina Elva , Styaningrum Farida 
Published: July 2023

Purpose: Firm value is one of the relevant company goals. Increasing firm value is supported by sustainability reporting and foreign ownership. The increase in firm value can be strengthened through a trusted Investment Opportunity Suitable to obtain returns that are attractive to investors and can be used as an injection of funds to implement sustainability reporting. Investigating the Investment Opportunity Set role in moderating the effect of sustainability reporting and foreign ownership on firm value. This study aims to investigate the Investment Opportunity Set in moderating the effect of sustainability reporting and foreign ownership on firm value.Method: This study uses a quantitative approach with independent variables on sustainability reporting and foreign ownership, the dependent variable on firm value, and the moderating variable. Investment Opportunity Set. This research is classified as non-experimental with cross-sectional data classification and documentation method. The research sample was 46 companies from 606 companies listed on the Indonesia Stock Exchange for 2013-2018. This study uses regression and Moderated Regression Analysis.Findings: The results showed that the Investment Opportunity Set does not moderate the effect of sustainability reporting on firm value. But Investment Opportunity Set moderate the influence of foreign ownership on firm value. Novelty: This study develops from previous research by proving that foreign ownership based on foreign investors is able to increase firm value. The study was conducted in all companies listed on the IDX that publish annual reports and sustainability reporting for the 2013-2018 period, this period is determined based on the first year of the change from the GRI G3 version to GRI G4 on May 22, 2013 which was launched in Amsterdam at the global sustainability reporting conference.
Impaired colonic motility in high-glycemic diet-induced diabetic mice is associated with disrupted gut microbiota and neuromuscular function
Authors: Pei Ying , Wang Rui , Chen Wanyu , Yi Shulin , Huang Chen , Liang Shaochan , Cao Hongying , Xu Yifei , Tan Bo 
Published: July 2023

Background
Similar to the high-fat diet (HFD), the high-glycemic diet (HGD) contributes to the development and progression of type 2 diabetes mellitus (T2DM). However, the effect of HGD on gastrointestinal motility in T2DM and its underlying mechanisms remain unclear.

Methods
Thirty C57BL/6J mice were randomly designated into the normal-feeding diet (NFD) group, HFD group, and HGD group. The plasma glucose, plasma insulin, and gastrointestinal motility were examined. Meanwhile, the tension of isolated colonic smooth muscle rings was calculated, and the gut microbiota was analyzed by 16s rDNA high-throughput sequencing.

Result
After 16 weeks of HGD feeding, obesity, hyperglycemia, insulin resistance, and constipation were observed in HGD mice. Autonomic contraction frequency of the colonic neuromuscular system and electrical field stimulation-induced contractions were reduced in HGD mice. On the contrary, neuronal nitric oxide synthase activity and neuromuscular relaxation were found to be enhanced. Finally, gut microbiota analysis revealed that Rhodospirillaceae abundance significantly increased at the family level in HGD mice. At the genus level, the abundance of Insolitispirillum increased remarkably, whereas Turicibacter abundance decreased significantly in HGD mice.

Conclusion
HGD induced constipation in obese diabetic mice, which we speculated that it may be related to neuromuscular dysmotility and intestinal microbiota dysbiosis.
Impact of vitamin B12 on the reproductive health of women with sickle cell disease: a narrative review
Authors: Agbalalah Tarimoboere , Robert Faith Owabhel , Amabebe Emmanuel 
Published: July 2023

Sickle cell disease (SCD) poses an increased risk of infertility, pregnancy complications and maternal and perinatal mortality among women of reproductive age. This risk is particularly higher for women in sub-Saharan Africa, where the disease burden is highest and access to comprehensive health care is limited, as well as in other countries with a high SCD prevalence due to migration. Disease-modifying treatments for SCD could directly and indirectly harm the ovaries, potentially compromising the quality and quantity of existing oocytes. Therefore, it is essential to explore alternative interventions, such as nutritional modifications that are less harmful and cost-effective in order to improve reproductive outcomes and enhance the overall well-being of both mother and child in this population. Maintaining optimal levels of B12 may possibly provide benefits to the ovaries and pregnancy by decreasing homocysteine levels, increasing nitric oxide (NO) bioavailability and promoting antioxidant and anti-inflammatory activities. Individuals living with SCD are more susceptible to vitamin B12 (B12) deficiency. However, there is a lack of clinical data investigating the relationship between systemic levels of B12, its supplementation, and reproductive outcome measures in SCD women. Therefore, this review aims to examine the current evidence regarding the impact of SCD on female reproductive health and the role of B12 in the reproductive biology of women living with SCD.

Lay summary
Poor reproductive health is a concern for patients with sickle cell disease (SCD). SCD can lead to damage to the ovaries. Most of the therapies for sickle cell disease are toxic to the ovaries, expensive and unavailable to affected women, particularly those living in resource-poor areas such as sub-Saharan Africa. There is a need to seek less harmful and affordable interventions such as nutrition to improve reproductive outcomes for women with SCD who are of child-bearing age. Good levels of vitamin B12 have been found to maintain ovarian health and pregnancy. Patients with SCD have been reported to have a high risk of vitamin B12 deficiency, but the impact of B12 on reproduction in this group of women is yet to be evaluated. The review explores current evidence of the impact of both SCD and B12 on female reproduction.
TEORÍA DEL CUERPO HUMANO EN ARISTÓTELES. SU BIOLOGÍA Y FILOSOFÍA TAL COMO APARECE EN DE PARTIBUS ANIMALIUM
Authors: Rodríguez López Juan 
Published: July 2023

Toda la biología de Aristóteles es teleológica, esencialista, individualista, organicista y no evolucionista. Estos principios de explicación del ser vivo son aplicados por Aristóteles al cuerpo humano. La capacidad de pensar del ser humano determina la forma de su cuerpo y sus características: liberación del peso de la parte superior, manos y brazos con características especiales, nalgas carnosas y musculosas que le permiten estar de pie y sentado, piernas con músculos para estar de pie, senos en la parte delantera gracias a la liberación de la función de sustentación de los miembros superiores y que permiten proteger el tórax y sus órganos vitales, ausencia de cola que permite estar sentado, pies de mayor tamaño en comparación con los animales para facilitar la bipedestación y la marcha. Por ello, el cuerpo humano no aparece realmente como modelo para el cuerpo de los animales sino como contrapartida, ya que lo que determina la forma de todo cuerpo vivo es su función (ergon) o forma de vivir, y la del ser humano para Aristóteles es vivir pensando, algo privativo del hombre, aunque comparta muchas otras capacidades cognitivas con los animales. Así, el deporte, en sus movimientos, es manifestación genuinamente humana y del pensamiento.
UNA CONSTATACIÓN ACTUAL DE LA VIGENCIA DEL IDEARIO OLÍMPICO EN LA EDUCACIÓN ESPAÑOLA A TRAVÉS DE UNA PROPUESTA EN EDUCACIÓN FÍSICA BASADA EN EL TRABAJO DE LA SOSTENIBILIDAD Y LOS PROYECTOS DE APRENDIZAJE-SERVICIO
Authors: Robles González Marta , Martínez Muñoz Luis Fernando 
Published: July 2023

El presente artículo se sustenta sobre el contenido del Trabajo de Fin de Grado (TFG) presentado, el pasado curso académico, en la Facultad de Formación de Profesorado y Educación de la Universidad Autónoma de Madrid con motivo de la finalización del Grado en Ciencias de la Actividad Física y el Deporte.
Sus objetivos, su orientación y su propuesta didáctica para las clases de Educación Física evidencian que el ideario que supone la base del Olimpismo, es una propuesta que se sigue viendo interesante para que esté implícitamente vigente, presente y desarrollado en España por parte del profesorado de Educación Física dentro de dicha asignatura.
A través de un análisis exhaustivo del centro educativo de prácticas donde se desarrolló la materia del prácticum se pudieron detectar, entre otras circunstancias: 1) la falta de interés por parte del alumnado por la asignatura de Educación Física, 2) la necesidad de trabajar la resolución de problemas y conflictos en las sesiones de Educación Física y 3) la inactividad física del alumnado, muy presente durante los tiempos de recreo.
Para subsanar dichas circunstancias, en el citado TFG se presentó una propuesta globalizada que combina el trabajo de los Objetivos de Desarrollo Sostenible a través de una programación didáctica para la Educación Física de 1º de Bachillerato y la puesta en marcha de proyectos de Aprendizaje-Servicio con carácter trimestral. Con ello se ha pretendido garantizar una EF de calidad, inclusiva, reflexiva y comprometida con el desarrollo sostenible, que viene a tener un paralelismo directo con los valores que propugna el ideario olímpico desde su creación.
El proyecto de Aprendizaje Servicio presentado se sitúa en el contexto de los recreos activos, favoreciendo la participación del alumnado de 1º de la Educación Secundaria Obligatoria del centro educativo de prácticas.
Discharge Best Practices of High-Risk Infants From Regional Children’s Hospital NICUs
Authors: Bourque Stephanie L. , Machut Kerri Z. , Chuo John , Cohen Susan , Johnson Yvette R. , Nanda Sharmila H. , Parsons Kimberly , Ponzek Rachel ,   Children’s Hospitals Neonatal Consortium Transitions of Care and Follow-up Focus Group
Published: July 2023

OBJECTIVES
Lack of discharge preparedness after NICU hospitalization is associated with risk of readmission and parental stress. Complex infants cared for at regional children’s hospital NICUs would benefit from a systematic approach to transition home. Our objective was to identify potential best practices for NICU discharge and examine priorities for incorporating these best practices in regional children’s hospital NICUs.

METHODS
We used techniques from quality improvement, including fish bone and key driver diagrams, yielding 52 potential best practice statements for discharge preparation. Using the modified Delphi method, we surveyed stakeholders on their level of agreement for the statement to be included in the final guideline regarding discharge processes and parental education. Consensus was defined as 85% agreement among respondents. To identify implementation feasibility and understand unit-level priorities, a prioritization and feasibility assessment survey was used to rank the top best practices and performed gap analyses for the first prioritized intervention.

RESULTS
Fifty of the 52 statements met the predefined criteria for consensus. The prioritization survey of potential best practice statements named assessment of families’ social determinants of health with a standardized tool as the top priority among respondents. Conducting gap analyses enabled an understanding of current practice, barriers, and affordances, allowing for implementation planning.

CONCLUSIONS
This multicenter and interdisciplinary expert panel reached a consensus on multiple potential best practices for complex discharge preparation from regional children’s hospital NICUs. Better support for families navigating the complex NICU discharge process has the potential to improve infant health outcomes.