bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality among patients with diffuse large B-cell lymphoma and mental disorders: a population-based study
Authors: Gong Inna Y , Cheung Matthew C , Chan Kelvin K W , Arya Sumedha , Faught Neil , Calzavara Andrew , Liu Ning , Odejide Oreofe O , Abel Gregory , Kurdyak Paul , Raphael Michael J , Kuczmarski Thomas , Prica Anca , Mozessohn Lee 
Published: August 2023

Abstract

Background
Mental disorders have been reported in patients with diffuse large B-cell lymphoma (DLBCL), but studies examining their association with mortality are lacking.

Methods
We conducted a population-based study using linked administrative health-care databases from Ontario, Canada. All patients with DLBCL 18 years of age or older treated with rituximab-based therapy between January 1, 2005, and December 31, 2017, were identified and followed until March 1, 2020. Mental disorders were defined as either preexisting or postdiagnosis (after lymphoma treatment initiation). Cox proportional hazards models were used to estimate the adjusted hazard ratio (HR) between mental disorders and 1-year and all-cause mortality while controlling for covariates.

Results
We identified 10 299 patients with DLBCL. The median age of the cohort was 67 years; 46% of patients were female, and 28% had a preexisting mental disorder. At 1-year follow-up, 892 (9%) had a postdiagnosis mental disorder, and a total of 2008 (20%) patients died. Preexisting mental disorders were not associated with 1-year mortality (adjusted HR = 1.06, 95% confidence interval [CI] = 0.96 to 1.17, P = .25), but postdiagnosis disorders were (adjusted HR = 1.51, 95% CI = 1.26 to 1.82, P = .0001). During a median follow-up of 5.2 years, 2111 (22%) patients had a postdiagnosis mental disorder, and 4084 (40%) patients died. Both preexisting and postdiagnosis mental disorders were associated with worse all-cause mortality (preexisting adjusted HR = 1.12, 95% CI = 1.04 to 1.20, P = .0024; postdiagnosis adjusted HR = 1.63, 95% CI = 1.49 to 1.79, P &lt; .0001).

Conclusions
Patients with DLBCL and mental disorders had worse short-term and long-term mortality, particularly those with postdiagnosis mental disorders. Further studies are needed to examine mental health service utilization and factors mediating the relationship between mental disorders and inferior mortality.
Testing times: Let’s leave the animals out of it
Authors: Ritskes-Hoitinga Merel , Watkins Justine , Jornick Pleun 
Published: August 2023

Abstract
Monumental changes in US drug regulation have brought the justification for animal based tests into the spotlight again. Pleun Jornick, Justine Watkins and Merel Ritskes-Hoitinga explore developments in legislation, science, and technology and look forward to a world without animal testing
Diversity and genetic architecture of agro-morphological traits in a core collection of European traditional tomato
Authors: Pons Clara , Casals Joan , Brower Matthijs , Sacco Adriana , Riccini Alessandro , Hendrickx Patrick , Figás Maria del Rosario , Fisher Josef , Grandillo Silvana , Mazzucato Andrea , Soler Salvador , Zamir Dani , Causse Mathilde , Díez Maria José , Finkers Richard , Prohens Jaime , Monforte Antonio Jose , Granell Antonio 
Published: August 2023

Abstract
European traditional tomato varieties have been selected by farmers given their consistent performance and adaptation to local growing conditions. Here we developed a multipurpose core collection, comprising 226 accessions representative of the genotypic, phenotypic, and geographical diversity present in European traditional tomatoes, to investigate the basis of their phenotypic variation, gene×environment interactions, and stability for 33 agro-morphological traits. Comparison of the traditional varieties with a modern reference panel revealed that some traditional varieties displayed excellent agronomic performance and high trait stability, as good as or better than that of their modern counterparts. We conducted genome-wide association and genome-wide environment interaction studies and detected 141 quantitative trait loci (QTLs). Out of those, 47 QTLs were associated with the phenotype mean (meanQTLs), 41 with stability (stbQTLs), and 53 QTL-by-environment interactions (QTIs). Most QTLs displayed additive gene actions, with the exception of stbQTLs, which were mostly recessive and overdominant QTLs. Both common and specific loci controlled the phenotype mean and stability variation in traditional tomato; however, a larger proportion of specific QTLs was observed, indicating that the stability gene regulatory model is the predominant one. Developmental genes tended to map close to meanQTLs, while genes involved in stress response, hormone metabolism, and signalling were found within regions affecting stability. A total of 137 marker–trait associations for phenotypic means and stability were novel, and therefore our study enhances the understanding of the genetic basis of valuable agronomic traits and opens up a new avenue for an exploitation of the allelic diversity available within European traditional tomato germplasm.
The X-ray corona in the black hole binary GRO J1655−40 from the properties of non-harmonically related quasi-periodic oscillations
Authors: Rout Sandeep K , Méndez Mariano , García Federico 
Published: August 2023

ABSTRACT
The study of quasi-periodic oscillations (QPOs) plays a vital role in understanding the nature and geometry of the Comptonizing medium around black hole X-ray binaries. The spectral-state dependence of various types of QPOs (namely A, B, and C) suggests that they could have different origins. The simultaneous presence of different types of QPOs would therefore imply the simultaneous occurrence of different mechanisms. In this work, we study the radiative properties of two non-harmonically related QPOs in the black hole binary GRO J1655−40 detected at the peak of the ultraluminous state during the 2005 outburst of the source. The two QPOs have been previously identified as types B and C, respectively. We jointly fit the phase-lag and rms spectra of the QPOs and the time-averaged spectrum of the source with the time-dependent Comptonization model vkompth to infer the geometry of the media producing the QPOs. The time-averaged spectrum required a hot disc of 2.3 keV and a steep power law with index 2.7, revealing that the source was in an ultraluminous state. The corona that drives the variability of the type-B QPO is smaller in size and has a lower feedback fraction than the one that drives the variability of the type-C QPO. This suggests the simultaneous presence of a horizontally extended corona covering the accretion disc and a vertically elongated jet-like corona that are responsible for the type-C and B QPOs, respectively.
American Indian Perspectives on Culturally Aligning a Digital Smoking Cessation Resource
Authors: Cooley Chelsea , Pickner Wyatt , Widome Rachel , Jennings Dylan , Stately Antony , Cole Ashley B , Cash Jennifer , Dorr Casey , Hernadez Carol , Hatsukami Dorothy , Businelle Michael , Carroll Dana Mowls 
Published: August 2023

AbstractIntroductionInnovative smoking cessation approaches that overcome barriers such as traveling to program site or that require the staff and infrastructure for sustaining are likely needed to improve smoking quit rates among American Indian (AI) peoples in the United States. In this study, qualitative methods identified recommendations from AI peoples to guide alignment of an evidence-based smoking cessation smartphone app (i.e., QuitGuide) to the culture and needs of AI persons.MethodsSemi-structured interviews were conducted with AI adults who smoke (n = 40) and with public health professionals (n = 6). Questions included: “The app asks if something triggered you to slip and lists several options. What options were you expecting to see on this list?” as well as how to make the app more engaging such as “What would make the app more helpful for AI peoples, like you, who want to quit smoking?.” Constant comparative techniques were used to develop codes and themes.ResultsLoss, grief, and not accessing traditional tobacco were put forward as smoking triggers to be addressed in the app. Features that help users connect with and learn about AI cultures and promote healing, such as encouraging traditional tobacco use, being in community, embracing Native spirituality, and participating in cultural crafting were recommended. Some noted the need to motivate AI peoples to think about legacy and ability to care for younger generations and Indigenizing the app with Native imagery.ConclusionsThemes pointed towards promotion of strengths-based factors, such as healing, cultural connectedness and traditional tobacco use, in the app.ImplicationsResults will be used to culturally align a smartphone app for smoking cessation among AI peoples and may be insightful for other tribal, federal, and state public health efforts aimed at advancing health equity for AI peoples.
Improving the Efficiency of Antimicrobial Stewardship Action in Acute Care Facilities
Authors: Heil Emily L , Justo Julie Ann , Bork Jacqueline T 
Published: August 2023

Abstract
Inpatient antimicrobial stewardship (AS) programs are quality improvement programs tasked with improving antibiotic practices by augmenting frontline providers’ antibiotic prescription. Prospective audit and feedback (PAF) and preauthorization (PRA) are essential activities in the hospital that can be resource intensive for AS teams. Improving efficiency in AS activities is needed when there are limited resources or when programs are looking to expand tasks beyond PAF and PRA, such as broad education or guideline development. Guidance on the creation and maintenance of alerts for the purpose of PAF reviews, modifications of antibiotic restrictions for PRA polices, and overall initiative prioritization strategies are reviewed. In addition, daily prioritization tools, such as the tiered approach, scoring systems, and regression modeling, are available for stewards to prioritize their daily workflow. Using these tools and guidance, AS programs can be productive and impactful in the face of resource limitation or competing priorities in the hospital.
Wear behavior of nano-La2O3 dispersed ferritic ODS steel developed by spark plasma sintering
Authors: Kumar Ashwani , Prasad Amit , Jayabalan Bhagyaraj , Mukherjee Subrata , Jain Jayant , Biswas Krishanu , Singh Sudhanshu S 
Published: August 2023

Abstract
In the present study, the wear behavior of the Fe–14Cr–1Ti–1W–0.5L2O3 oxide dispersion strengthened (ODS) steels has been reported. The ball-on-disc wear tester with silicon carbide ball as counter surface was used to perform the wear tests. The effect of normal load (10–40 N with the interval of 10 N) on the wear behavior of the alloy has been investigated. Furthermore, to understand the operative wear mechanism of the alloy, detailed microstructural and compositional analyses have also been carried out using scanning electron microscopy. The highest width of the wear track was obtained as 896 ± 78 µm at 40 N normal load. The wear rate of the alloy was found to increase from 4.54 ± 0.12×10-6 mm3/m to 25.48 ± 1.15×10-6 mm3/m with the normal load from 10 to 40 N at constant sliding velocity and distance. Moreover, the microstructure analyses of the worn surfaces, wear debris and counter surface have shown the prominent wear mechanism to be a combination of adhesion, abrasion, oxidation and plastic deformation. The addition of lanthana was found to reduce the wear rate of ferritic steels.
Strigolactones and Shoot Branching: What Is the Real Hormone and How Does It Work?
Authors: Dun Elizabeth A , Brewer Philip B , Gillam Elizabeth M J , Beveridge Christine A 
Published: August 2023

Abstract
There have been substantial advances in our understanding of many aspects of strigolactone regulation of branching since the discovery of strigolactones as phytohormones. These include further insights into the network of phytohormones and other signals that regulate branching, as well as deep insights into strigolactone biosynthesis, metabolism, transport, perception and downstream signaling. In this review, we provide an update on recent advances in our understanding of how the strigolactone pathway co-ordinately and dynamically regulates bud outgrowth and pose some important outstanding questions that are yet to be resolved.
The Changing Economics of Knowledge Production
Authors: Abis Simona , Veldkamp Laura 
Published: August 2023

Abstract
Big data technologies change the way in which data and labor combine to create knowledge. Is this a modest innovation or a data revolution? Using hiring and wage data, we estimate firms’ data stocks and their knowledge production functions. Quantifying changes in production functions informs us about the likely long-run changes in output, in factor shares, and in the distribution of income, due to big data technologies. For the investment management industry, our structural estimates predict a 5% decline in the labor share of income; that change is comparable to similar estimates for the industrial revolution.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online
Cohesin Subunit RAD21 Regulates the Differentiation and Self-Renewal of Hematopoietic Stem and Progenitor Cells
Authors: Kumar Praveen , Zhang Nenggang , Lee John , Cheng Haizi , Kurtz Kristen , Conneely Shannon E , Sasidharan Rajkumar , Rau Rachel E , Pati Debananda 
Published: August 2023

Abstract
Recent studies suggest that chromosomal cohesin complex proteins are important in regulating hematopoiesis and may contribute to myeloid malignancies. To investigate the effects of perturbing the cohesin subunit protein RAD21 on normal hematopoiesis, we used conditional knockout (cKO) mouse models. While cohesin is vital for hematopoietic stem cell (HSC) function, Rad21 haploinsufficiency (Rad21Δ/+) led to distinct hematopoietic phenotypes. Our findings revealed that Rad21Δ/+ cells exhibited decreased hematopoietic reconstitution in competitive bone marrow transplantation assays. This reduction in peripheral blood chimerism was specifically observed in the lymphoid compartment, while the chimerism in the myeloid compartment remained unaffected. Rad21 haploinsufficiency also resulted in changes in the hematopoietic stem and progenitor cells (HSPC) and myeloid progenitor compartments, with a significant accumulation of granulocyte-macrophage progenitors in the bone marrow. We observed differential gene expression in Rad21Δ/+ LSK (Lin− Sca1−Kit+) cells, including genes required for HSPC function and differentiation, such as Setdb1, Hmga2, Ncor1, and Myb. In addition, we observed a notable decrease in the expression of genes related to the interferon response and a significant reduction in the expression of genes involved in the IL2-STAT5 signaling pathways. Our studies suggest that RAD21 protein and level of its post-translational modifications in the bone marrow cells may play a potential role in hematopoiesis. Overall, Rad21 haploinsufficiency impairs hematopoietic differentiation and increases HSC self-renewal.
Burma Terrane Amber Fauna Shows Connections to Gondwana and Transported Gondwanan Lineages to the Northern Hemisphere (Araneae: Palpimanoidea)
Authors: Wood Hannah M , Wunderlich Jörg 
Published: August 2023

Abstract
Burmese amber is a significant source of fossils that documents the mid-Cretaceous biota. This deposit was formed around 99 Ma on the Burma Terrane, which broke away from Gondwana and later collided with Asia, although the timing is disputed. Palpimanoidea is a dispersal-limited group that was a dominant element of the Mesozoic spider fauna, and has an extensive fossil record, particularly from Burmese amber. Using morphological and molecular data, evolutionary relationships of living and fossil Palpimanoidea are examined. Divergence dating with fossils as terminal tips shows timing of diversification is contemporaneous with continental breakup.Ancestral range estimations show widespread ancestral ranges that divide into lineages that inherit different Pangean fragments, consistent with vicariance. Our results suggest that the Burmese amber fauna has ties to Gondwana due to a historical connection in the Early Cretaceous, and that the Burma Terrane facilitated biotic exchange by transporting lineages from Gondwana into the Holarctic in the Cretaceous.
Water binders in beef patties increase yield and extend shelf life
Authors: Van Buren Jessie B , Puga Kendelle J , Hoffman Kacie C , Nasados James A , Bass Phillip D , Colle Michael J 
Published: August 2023

Abstract
Identifying nonallergenic, natural water binders to increase beef patty juiciness and extend shelf life would be beneficial to the beef industry. The objective of this study was to determine the effect of integrating water binders into beef hamburger patties on cooking yield, shelf life, and pH. Five water binder treatments were added at 2% of the meat block. Treatments included potato extract, citrus fiber, dried refried beans, potato peel, or no binder (control). Six batches of each treatment were made and two patties from each batch were analyzed for each parameter. Fluid yield and lipid oxidation were measured on cooked, frozen (210 d), and reheated patties. Raw patties were used to evaluate color, fluid loss, and lipid oxidation over 4 d of retail display. Patties containing citrus fiber improved reheat yield (P = 0.03) and overall yield (P &lt; 0.01). Citrus patties had the lowest pH (P &lt; 0.01) at 5.45. On days 0 and 4 of retail display, patties containing a water binder treatment had less lipid oxidation than the control patties (P &lt; 0.01). Additionally, the cooked, frozen, and reheated patties, had less lipid oxidation when containing a water binder treatment than the control patties (P &lt; 0.01). Citrus fiber improved water retention in reheated patties, and all water binders delayed lipid oxidation in raw, cooked, frozen, and reheated patties. Increasing patty juiciness and delaying lipid oxidation will improve consumers’ eating experience of reheated, precooked patties in settings such as school or hospital cafeterias.
Evaluation of a Lactococcus lactis-based dried fermentation product administered through drinking water on nursery pig growth performance, fecal Escherichia coli virulence genes and pathotypes, antibiotic usage, and mortality
Authors: Warner Alan J , Tokach Mike D , Carrender Brittany , Amachawadi Raghavendra G , Labbé Alain , Heuser Walter , Coble Kyle , DeRouchey Joel M , Woodworth Jason C , Goodband Robert D , Kalam Ramya , Shi Xiaorong , Nagaraja T G , Gebhardt Jordan T 
Published: August 2023

Abstract
A total of 34,749 pigs were used in two experiments to evaluate the effects of a postbiotic dried fermentation product (DFP) administered through drinking water on nursery pig growth performance, antibiotic injection frequency, morbidity, mortality, fecal consistency, and characterization of fecal Escherichia coli. The DFP is composed of bioactive molecules derived from Lactococcus lactis. In Exp. 1, 350 barrows (DNA Line 200 × 400; initial body weight [BW] 6.1 ± 0.01 kg) were used in a 42-d study with five pigs per pen and 35 pens per treatment. The DFP was supplied for 14 d at a target dosage of 24 mg/kg BW using a water medicator at a 1:128 dilution. On days 7 and 14, fecal samples were collected for dry matter (DM) and to determine, by a multiplex polymerase chain reaction (PCR) assay, prevalence of 11 virulence genes characteristic of E. coli pathotypes. There was no evidence (P &gt; 0.10) for differences for growth, incidence of diarrhea, number of antibiotic injections, removals, or fecal DM. On both fecal collection days, E. coli virulence genes were present with day 7 samples positive for genes that encode for hemolysins (hlyA, exhA), intimin (eae), and enteroaggregative heat-stable enterotoxin (astA). Prevalence of enterotoxin genes (elt, estA, estB, astA) increased on day 14, but DFP had no effects on the prevalence of any of the virulence genes. A total of 32 out of 72 E. coli isolates were identified as enterotoxigenic pathotype and all except one were from day 14 fecal samples. Fourteen isolates were positive for F4 fimbria and one isolate was positive for F4 and F18 fimbriae. In Exp. 2, 34,399 nursery pigs (initially 5.6 kg) were used in 20 nursery barns with 10 barns per treatment (control or DFP). The target dosage of the DFP for the first 14 d was 35 mg/kg BW. Following the 14-d supplementation period, pigs continued to be monitored for approximately 31 d. There was no evidence (P &gt; 0.05) for the DFP to influence the overall percentage of pigs that died or growth performance. From days 0 to 14, providing the DFP reduced (P &lt; 0.05) the percentage of pigs that were euthanized. However, providing the DFP increased (P &lt; 0.05) the overall percentage of pigs that were euthanized and total mortality. For the number of antibiotic injections (treatment interventions), providing the DFP reduced the number of injections for the common period (P &lt; 0.001) and overall (P = 0.002). These results indicate that the DFP did not influence growth performance but providing the DFP in Exp. 2 led to increased total nursery pig mortality.
Potential Implication of in ovo Feeding of Phytogenics in Poultry Production
Authors: Akosile Oluwaseun Ayomide , Kehinde Festus Olasehinde , Oni Aderanti Ifeoluwa , Oke Oyegunle Emmanuel 
Published: August 2023

Abstract
Hatchery’s goals include maximizing revenue by achieving high hatchability with day-old birds of excellent quality. The advancement of technology has benefited the poultry sector since breeding and genetics technology have increased the rates of meat maturation in developing birds in a short period of time. Excessive use of in-feed antibiotics has been shown in studies to increase the chance of resistance to human infections. Bacterial resistance and antibiotic residues in animal products raised concerns about using antibiotics as growth promoters, eventually leading to a prohibition on using in-feed antibiotics in most industrialized nations. In ovo technology is a novel method for delivering bioactive chemicals to developing avian embryos. In ovo feeding technologies may provide additional nutrients to the embryos before hatching. The introduction of bioactive compounds has the potential to assist in decreasing and eventually eliminating the problems associated with traditional antibiotic delivery in chicken production. Phytobiotics were advocated as an alternative by researchers and dietitians. So far, several studies have been conducted on the use of phytogenic feed additives in poultry and swine feeding. They have primarily demonstrated that phytobiotics possess antibacterial, antioxidant, anti-inflammatory, and growth-stimulating properties. The antioxidant effect of phytobiotics can improve the stability of animal feed and increase the quality and storage duration of animal products. In general, the existing documentation indicates that phytobiotics improve poultry performance. To effectively and efficiently use the in ovo technique in poultry production and advance research in this area, it is important to have a thorough understanding of its potential as a means of nutrient delivery during the critical stage of incubation, its effects on hatching events and posthatch performance, and the challenges associated with its use. Overall, this review suggests that in ovo feeding of phytobiotics has the potential to improve the antioxidant status and performance of chickens.