bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cascade Genetic Risk Education and Testing in Families With Hereditary Cancer Syndromes: A Pilot Study
Authors: Katz Steven J. , Abrahamse Paul , Hodan Rachel , Kurian Allison W. , Rankin Aaron , Tocco Rachel S. , Rios-Ventura Sonia , Ward Kevin C. , An Lawrence C. 
Published: March 2023

PURPOSE: Cascade genetic risk evaluation in families with hereditary cancer can reduce the burden of disease but the rate of germline genetic testing in relatives of patients at risk is low. METHODS: We identified all 277 women diagnosed with breast cancer in Georgia in 2017 who linked to a clinically actionable germline pathogenic variant through a Surveillance, Epidemiology, and End Results registry-variant linkage initiative. We surveyed them, and then invited eligible respondents to an online platform hosted by a navigator that offered cancer genetic risk education and germline genetic testing to untested relatives. We randomly assigned patient-family clusters at the time of the patient enrollment offer to free versus $50 (USD) test cost. Patients invited relatives to join the study through personalized e-mail. Enrolled relatives received online cancer genetic education and the opportunity to order clinical germline genetic testing through the platform. The primary outcome was the number of relatives who ordered genetic testing. RESULTS: One hundred twenty-five of 277 patients completed surveys (45.2%). Most respondents were eligible for the trial offer (113 of 125; 90.4%). In the free testing arm, 20 of 56 eligible patients participated (35.7% of eligible respondents) and they invited 28 relatives: 12 relatives enrolled and 10 ordered testing. In the $50 (USD) arm, 16 of 57 eligible patients participated (28.1%) and they invited 38 relatives: 18 relatives enrolled and 17 ordered testing. CONCLUSION: Cascade genetic testing in families with hereditary cancer syndromes accrued through a population-based cancer registry can be achieved through an online platform that offers genetic risk education and low-cost testing to relatives. A modest charge did not appear to influence the percentage of participating patients, numbers of participating relatives, and numbers of relatives who received genetic testing.
Development and External Validation of the Spinal Tumor Surgery Risk Index
Authors: Alomari Safwan , Theodore John , Ahmed A. Karim , Azad Tej D. , Lubelski Daniel , Sciubba Daniel M , Theodore Nicholas 
Published: March 2023

BACKGROUND:Patients undergoing surgical procedures for spinal tumors are vulnerable to major adverse events (AEs) and death in the postoperative period. Shared decision making and preoperative optimization of outcomes require accurate risk estimation.OBJECTIVE:To develop and validate a risk index to predict short-term major AEs after spinal tumor surgery.METHODS:Prospectively collected data from multiple medical centers affiliated with the American College of Surgeons National Surgical Quality Improvement Program from 2006 to 2020 were reviewed. Multiple logistic regression was used to assess sociodemographic, tumor-related, and surgery-related factors in the derivation cohort. The spinal tumor surgery risk index (STSRI) was built based on the resulting scores. The STSRI was internally validated using a subgroup of patients from the American College of Surgeons National Surgical Quality Improvement Program database and externally validated using a cohort from a single tertiary center.RESULTS:In total, 14 982 operations were reviewed and 4556 (16.5%) major AEs occurred within 30 days after surgery, including 209 (4.5%) deaths. 22 factors were independently associated with major AEs or death and were included in the STSRI. Using the internal and external validation cohorts, the STSRI produced an area under the curve of 0.86 and 0.82, sensitivity of 80.1% and 79.7%, and specificity of 74.3% and 73.7%, respectively. The STSRI, which is freely available, outperformed the modified frailty indices, the American Society of Anesthesiologists classification, and the American College of Surgeons risk calculator.CONCLUSION:In patients undergoing surgery for spinal tumors, the STSRI showed the highest predictive accuracy for major postoperative AEs and death compared with other current risk predictors.
Maternal anaemia care in Kano state, Nigeria: an exploratory qualitative study of experiences of uptake and provision
Authors: Kuliya-Gwarzo Aisha , Tancred Tara , Gordon Daniel , Bates Imelda , Raven Joanna 
Published: March 2023

Background: Maternal anaemia (anaemia in pregnancy, childbirth, and the postpartum period) remains a persistent challenge, particularly in Kano State, Nigeria, which has the highest prevalence of maternal anaemia globally, at 72%. Methods: We conducted a qualitative study in Murtala Muhammad Specialist Hospital in Kano State, Nigeria. We aimed to identify factors constraining uptake and provision of maternal anaemia care, exploring perspectives across different stakeholders. We carried out 10 key informant interviews with policymakers and hospital managers, 28 in-depth interviews with healthcare providers and pregnant women using antenatal services and four focus group discussions with pregnant women’s husbands and mothers-in-law. Data were analysed thematically. Results: Issues with provision include a lack of provider training and guidelines specific to maternal anaemia and blood transfusion, insufficient staff to meet increasing demand, and inadequate resources. Issues with uptake include the inability to afford informal user fees, distrust in health services and the blood transfusion process, and a lack of understanding of the causes, consequences, and treatment for anaemia, resulting in poor uptake of care and adherence to treatment. Conclusions: This study recommends the implementation of standardized guidelines and training sessions to better support healthcare providers in offering quality services and increasing funding allocated to supporting maternal anaemia care. Education initiatives for service users and the public are also recommended to build public trust in health services and to improve understanding of maternal anaemia.
Online synchronous inspection and system optimization of flexible food packaging bags by using machine vision and sensing technique
Authors: Gu Lizhi , Li Qiong , Huang Ehui , Li Mingrui , Gao Shanping , Yen Kin Sam , Li Shuting , Zhou Junqin , Chen Zhenjie 
Published: March 2023

Flexible food packaging in the market is increasingly favored, and its quality is essential and indispensable for safety and convenience. However, quality inspection still stays in the manual stage, or partially manual inspection remains, in production, leading low efficiency, lack and even false inspection, hardly meeting the requirements of the modern output. This paper proposes and optimizes the design of an automatic detection system with intelligence for flexible food packaging bag, which can effectively be adopted to check the quality of packaging trademark patterns, fillers, and sealing quality. The inspection system runs with two-stage structure, machine vision, pressure sensing and synchronization to improve efficiency and ensure the normal production beat. Simplex Method is adopted to determine the best synchronous speeds online to achieve the best expectation. Comparison has been made between the manual inspection and our automatic operation, the sample of 10000 was statistically analyzed and results have shown that two workers were saved and the correctness rate of inspection raised up to 999.8‰.
Pregnant women’s awareness, perception, and acceptability of COVID-19 vaccine attending antenatal clinics in Bharatpur, Nepal
Authors: Dhakal Radha , Shapkota Sushma , Shrestha Parita , Adhikari Prativa , Nepal Shobhana 
Published: March 2023

Background
Vaccine is the cost-effective and reliable public health intervention to combat the emerging COVID-19 pandemic. The vaccination is considered safe and effective at any stage of pregnancy; however, pregnant women show more vaccine hesitation than the general population. This study aims to assess pregnant women’s awareness, perception, and acceptability of COVID-19 vaccine attending antenatal clinics.

Methods
An institutional-based cross-sectional analytical study design was used to assess the acceptance of the COVID-19 vaccine and associated factors among pregnant women between Feb-1 to March-30–2022 at antenatal clinics of Bharatpur Chitwan using systematic random sampling. A semi-structured interview schedule was used to collect data from 644 respondents. Collected data were analysed using descriptive and inferential statistics like the Pearson chi-square test and logistic regression analysis.

Results
The COVID-19 vaccine acceptance was found to be 22% and ethnicity (AOR = 1.826; 95% CI = 1.215–2.745), education level (AOR = 1.773; 95%CI = 1.025–3,068;), history of COVID-19 infection (AOR = 3.63; 95% CI = 1.323–9.956;), number of child (AOR = 5.021; 95% CI 1.989–12.677;), trimester (week of pregnancy) (AOR = 2.437; 95% CI 1.107–5.366) and level of perception (AOR = 2.152; 95% CI 1.109–4.178) were found to be statistically significant for acceptance of COVID-19 vaccine among pregnant mother.

Conclusions
In this study, low levels of vaccine acceptance were found. Several influential factors like occupation, history of COVID-19 infection, number of pregnancies, week of gestation, and level of attitude were found to be significant for acceptance of COVID-19 vaccine among pregnant women. Everyone needs vaccine acceptance to get herd immunity and reduce the COVID-19 infection. But Vaccine hesitancy is one of the significant threats to the COVID-19 rollout and successful pandemic mitigation. Therefore, properly disseminating information and removing misperceptions about the COVID-19 vaccine is necessary to raise the acceptance.
Reward-related self-agency is disturbed in depression and anxiety
Authors: Mehta Marishka M. , Na Soojung , Gu Xiaosi , Murrough James W. , Morris Laurel S. 
Published: March 2023

Background
The sense of agency, or the belief in action causality, is an elusive construct that impacts day-to-day experience and decision-making. Despite its relevance in a range of neuropsychiatric disorders, it is widely under-studied and remains difficult to measure objectively in patient populations. We developed and tested a novel cognitive measure of reward-dependent agency perception in an in-person and online cohort.

Methods
The in-person cohort consisted of 52 healthy control subjects and 20 subjects with depression and anxiety disorders (DA), including major depressive disorder and generalized anxiety disorder. The online sample consisted of 254 participants. The task consisted of an effort implementation for monetary rewards with computerized visual feedback interference and trial-by-trial ratings of self versus other agency.

Results
All subjects across both cohorts demonstrated higher self-agency after receiving positive-win feedback, compared to negative-loss feedback when the level of computer inference was kept constant. Patients with DA showed reduced positive feedback-dependent agency compared to healthy controls. Finally, in our online sample, we found that higher self-agency following negative-loss feedback was associated with worse anhedonia symptoms.

Conclusion
Together this work suggests how positive and negative environmental information impacts the sense of self-agency in healthy subjects, and how it is perturbed in patients with depression and anxiety.
Health-related quality of life of daily-life-affected benign essential blepharospasm: Multi-center observational study
Authors: Hirunwiwatkul Parima , Supawatjariyakul Wajamon , Jariyakosol Supharat , Apinyawasisuk Supanut , Sriratanaban Jiruth , Chongpison Yuda , Jagota Priya , Aui-aree Nipat , Witthayaweerasak Juthamat , Setthawatcharawanich Suwanna , Kitthaweesin Kitthisak , Chirapapaisan Niphon , Chaimongkoltrakul Piyawadee , Laowanapiban Poramaet , Hansapinyo Linda , Panpitpat Suthida , Kurathong Sireedhorn , Nimworaphan Jirat , Thitiwichienlert Suntaree , Vanikieti Kavin , Samipak Narong , Srimanan Worapot , Mekhasingharak Nattapong , Chaitanuwong Pareena 
Published: March 2023

Purpose
To compare Thais’ health-related quality of life (HRQOL) and severity grading, efficacy and safety in daily-life-affected benign essential blepharospasm (BEB) patients at baseline and after Botulinum toxin type A (BTX-A) treatment.

Design
Prospective-observational study.

Participants
BEB patients with Jankovic rating scale (JRS) at least 3 in both severity and frequency graded from 14 institutes nationwide were included from August 2020 to June 2021.

Methods
Demographic data, HRQOL evaluated by the Thai version of EQ-5D-5L and NEI-VFQ-25 questionnaires, and severity grading score evaluated by Jankovic rating scale (JRS) at baseline, 1, and 3 months after the treatment were collected. The impact of the BTX-A injections and their complications were recorded.

Results
184 daily-life-affected BEB patients were enrolled; 159 patients (86.4%) had complete data with a mean age of 61.40±10.09 years. About 88.05% were female, and 10.1% were newly diagnosed. Most of the patients had bilateral involvement (96.9%) and 12.6% had history of BEB-related accident. After BTX-A treatment, HRQOL improved significantly in 4 dimensions of EQ-5D-5L, except self-care. The EQ_VAS (mean±SD) was 64.54±19.27, 75.13±15.37, 73.8±15.85 (p<0.001) and EQ-5D-5L utility score was 0.748±0.23, 0.824±0.19 and 0.807±0.19 at baseline, 1, 3 months after treatment, respectively. From NEI-VFQ-25, HRQOL also improved in all dimensions, except eye pain. The JRS improved in all patients. Self-reported minor adverse events were 22.6%, which mostly resolved within the first month.

Conclusion
Daily-life-affected BEB impacted HRQOL in most dimensions from both generic and visual-specific questionnaires. BTX-A treatment not only decreased disease severity, but also improved quality of life.
An Unusual Cause of GI Blood Loss
Authors: Travers Paul , Pang Maoyin 
Published: March 2023

ABSTRACT
Chronic gastrointestinal bleeding is the leading cause of iron deficiency anemia in developed countries, and most occult bleeds are attributed to upper gastrointestinal tract lesions, which are broadly categorized into mass lesions, vascular, infectious, and inflammatory abnormalities. Gastric polyps account for an exceedingly small portion of these lesions but are of clinical importance because of the risk for progression to malignancy. We describe a patient found to have a gastric foveolar-type adenoma as a rare cause of iron deficiency anemia, with an incidentally found gastric neuroendocrine tumor.
Levetiracetam Liver Injury: A Benign Antiepileptic Agent?
Authors: Hegazy Yassmin , Axley Page , Lee Goo , Gray Meagan 
Published: March 2023

ABSTRACT
Levetiracetam is a commonly prescribed antiepileptic agent and has rarely been linked to hepatotoxicity. This case describes a patient with drug-induced autoimmune hepatitis secondary to levetiracetam.
Synthesis and stability of phospholipid-encapsulated nano-selenium
Authors: Huang Jinhui , Lin Xue , Zhu Yongchuang , Sun Xuejiao , Chen Jiesheng , Cui Yingde 
Published: March 2023

Abstract
Red elemental nano-selenium, which is an important biological form of selenium, exhibits very low toxicity and remarkable biological properties and thus has several positive effects. For instance, it shows antioxidation and antistress characteristics, promotes growth and improves immunity. However, owing to its nanoscale size, it is very difficult to disperse and stabilize during synthesis and storage. In this study, nanoscale selenium with a mass content of 2.06% and an average particle size of 49 nm was prepared by the chemical reduction method. The analysis demonstrated that the surface phospholipids formed lamellar structures after directional freezing, and the nano-selenium particles were distributed in the middle of the lamellar. The nano-selenium particles were efficiently dispersed due to their lamellar structure and amphiphilicity. The particles displayed excellent stability and remained relatively unchanged after 20 days of storage in solution or solid state. The difficulties associated with the dispersion and storage stability of nanometer selenium during preparation were solved.
Digital natives aren’t concerned much about privacy, or are they?
Authors: Maier Edith , Doerk Michael , Reimer Ulrich , Baldauf Matthias 
Published: March 2023

Abstract
Voice assistants have become embedded in people’s private spaces and domestic lives where they gather enormous amounts of personal information which is why they evoke serious privacy concerns. The paper reports the findings from a mixed-method study with 65 digital natives, their attitudes to privacy and actual and intended behaviour in privacy-sensitive situations and contexts. It also presents their recommendations to governments or organisations with regard to protecting their data. The results show that the majority are concerned about privacy but are willing to disclose personal data if the benefits outweigh the risks. The prevailing attitude is one characterised by uncertainty about what happens with their data, powerlessness about controlling their use, mistrust in big tech companies and uneasiness about the lack of transparency. Few take steps to self-manage their privacy, but rely on the government to take measures at the political and regulatory level. The respondents, however, show scant awareness of existing or planned legislation such as the GDPR and the Digital Services Act, respectively. A few participants are anxious to defend the analogue world and limit digitalization in general which in their opinion only opens the gate to surveillance and misuse.
Analysis of microwave irradiation on the lethal conditions for insect pest in rice and its influence and regulation on the quality of rice
Authors: Song Wenzhong , Chang Xiaoling , Wu Long , Wang Ruifang 
Published: March 2023

Abstract
In view of the problem that conventional insecticidal methods cannot inhibit the hatching of insect eggs in rice, microwave heating was used to kill the insect eggs hidden in the rice grains. The lethal conditions of microwave irradiation on insect pests in rice and the effects of microwave irradiation on the quality of rice were studied, and the process conditions that can both ensure the quality of rice and kill insects were put forward. The microwave energy density parameter was used to evaluate the lethal conditions of microwave irradiation for insect pests in rice. The results showed that the lethality ratio of insect pests was 100% when the microwave energy density was higher than 0.0325 kW h/kg. Both microwave power density and microwave power affected the quality of rice. The results concluded that the cracking ratio, chalkiness and amylose content were increased with the increase of microwave power at the same microwave power density, while the free fatty acid content was decreased. Through the study of variable microwave power process, it was found that the cracking ratio and chalkiness can be controlled below 1.5% when the heating rate of rice at the later stage of microwave irradiation was less than 0.2 °C/s. The use of two-stage variable microwave power process can eventually ensure the disinfestation and the quality of rice simultaneously.
A third polymorph of the zwitterionic complex trichlorido-((dimethylphosphoryl)methanaminium-κO)zinc(II)
Authors: Reiss Guido J. 
Published: March 2023

Abstract
By the reaction of (dimethylphosphoryl)methanamine (dpma) with one equivalent of zinc(II) chloride in a concentrated hydrochloric acid solution and subsequent slow evaporation of the solvent, the title compound (dpmaH)ZnCl3 was obtained in quantitative yield. The primary reaction product mainly consists of larger brick-shaped colorless and smaller cuboide colorless crystals. Long-time storage over several months of these crystals in the mother liquor yielded a third polymorph (P21/n; a = 9.6639(1); b = 10.0271(1); c = 11.2446(1) Å; β = 98.964(1)°) of this compound. Similar to the two other modifications, its crystal structure consists of a zwitterionic dpmaHZnCl3 complex containing the cationic dpmaH+ ligand, which coordinates the zinc atom through its oxygen atom. Hydrogen bonds connect neighboring zwitterionic complexes to a layered structure. The motif of a hydrogen bonded dimer, similar to that found in the chain structure of polymorph I, is also present, but in the title structure these dimers form hydrogen bonds in two dimensions.
Konzept zur selektiven Modelladaption durch Clustering von Prozessdaten
Authors: Brecher Christian , Frenkel Nils , Lohrmann Vincent , Ochel Janis , Strachkov Anton , Wiesch Marian , Fey Marcel 
Published: March 2023

Abstract
Die indirekte Bestimmung von Maschinen- und Komponentenzuständen erfordert eine signalquellenabhängige Modellparametrierung. Eine zentrale Herausforderung ist hierbei die Adaption bestehender Modelle für neue Randbedingungen. In diesem Beitrag wird ein Konzept zum datengetriebenen Clustering von geschlossenen Prozessabschnitten vorgestellt, mit dessen Hilfe eine gezielte Modellanpassung und -wiederverwendung ermöglicht werden. Eine Anwendung wird anhand zweier Anwendungsmöglichkeiten konzeptionell illustriert.
Category Trumps Shape as an Organizational Principle of Object Space in the Human Occipitotemporal Cortex
Authors: Yargholi Elahe' , Op de Beeck Hans 
Published: March 2023

The organizational principles of the object space represented in the human ventral visual cortex are debated. Here we contrast two prominent proposals that, in addition to an organization in terms of animacy, propose either a representation related to aspect ratio (stubby-spiky) or to the distinction between faces and bodies. We designed a critical test that dissociates the latter two categories from aspect ratio and investigated responses from human fMRI (of either sex) and deep neural networks (BigBiGAN). Representational similarity and decoding analyses showed that the object space in the occipitotemporal cortex and BigBiGAN was partially explained by animacy but not by aspect ratio. Data-driven approaches showed clusters for face and body stimuli and animate-inanimate separation in the representational space of occipitotemporal cortex and BigBiGAN, but no arrangement related to aspect ratio. In sum, the findings go in favor of a model in terms of an animacy representation combined with strong selectivity for faces and bodies.SIGNIFICANCE STATEMENTWe contrasted animacy, aspect ratio, and face-body as principal dimensions characterizing object space in the occipitotemporal cortex. This is difficult to test, as typically faces and bodies differ in aspect ratio (faces are mostly stubby and bodies are mostly spiky). To dissociate the face-body distinction from the difference in aspect ratio, we created a new stimulus set in which faces and bodies have a similar and very wide distribution of values along the shape dimension of the aspect ratio. Brain imaging (fMRI) with this new stimulus set showed that, in addition to animacy, the object space is mainly organized by the face-body distinction and selectivity for aspect ratio is minor (despite its wide distribution).