bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the interplay between daily life fatigue and physical activity after subarachnoid hemorrhage: an ecological momentary assessment and accelerometry study
Authors: de Vries Elisabeth A. , Heijenbrok-Kal Majanka H. , van Kooten Fop , Giurgiu Marco , Ribbers Gerard M. , van den Berg-Emons Rita J.G. , Bussmann Johannes B.J. 
Published: September 2023

Abstract
Background
Fatigue is one of the most commonly reported symptoms after subarachnoid hemorrhage (SAH) and is indirectly associated with physical activity (PA). Associations between fatigue and PA are primarily examined based on conventional measures (i.e. a single fatigue score or average PA levels), thereby assuming that fatigue and PA do not fluctuate over time. However, levels of fatigue and PA may not be stable and may interrelate dynamically in daily life. Insight in direct relationships between fatigue and PA in daily life, could add to the development of personalized rehabilitation strategies. Therefore we aimed to examine bidirectional relationships between momentary fatigue and PA in people with SAH.

Methods
People (n = 38) with SAH who suffer from chronic fatigue were included in an observational study using Ecological Momentary Assessment (EMA) and accelerometry. Momentary fatigue was assessed on a scale from 1 to 7 (no to extreme fatigue), assessed with 10–11 prompts per day for 7 consecutive days using EMA with a mobile phone. PA was continuously measured during this 7-day period with a thigh-worn Activ8 accelerometer and expressed as total minutes of standing, walking, running and cycling in a period of 45 min before and after a momentary fatigue prompt. Multilevel mixed model analyses including random effects were conducted.

Results
Mean age was 53.2 years (SD = 13.4), 58% female, and mean time post SAH onset was 9.5 months (SD = 2.1). Multilevel analyses with only time effects to predict fatigue and PA revealed that fatigue significantly (p < 0.001) increased over the day and PA significantly (p < 0.001) decreased. In addition, more PA was significantly associated with higher subsequent fatigue (β = 0.004, p < 0.05) and higher fatigue was significantly associated with less subsequent PA (β=-0.736, p < 0.05). Moreover, these associations significantly differed between participants (p < 0.001).

Conclusions
By combining EMA measures of fatigue with accelerometer-based PA we found that fatigue and PA are bidirectionally associated. In addition, these associations differ among participants. Given these different bidirectional associations, rehabilitation aimed at reducing fatigue should comprise personalized strategies to improve both fatigue and PA simultaneously, for example by combining exercise therapy with cognitive behavioral and/or energy management therapy.
Developing a serious game for gaze stability rehabilitation in children with vestibular hypofunction
Authors: Ortega Solís José , Reynard Pierre , Spruyt Karen , Bécaud Cécile , Ionescu Eugen , Thai-Van Hung 
Published: September 2023

Abstract
Background
Children with vestibular hypofunction (VH) may have gaze instability, balance disorders, and delayed postural-motor development. Gaze stabilization exercises (GSE) are designed to improve dynamic visual acuity (DVA). We aimed to assess the acceptability of a serious game prototype called Kid Gaze Rehab (KGR) designed to implement GSE training in children with VH, combined with traditional vestibular rehabilitation. Effects on DVA and motor performance were also analyzed.

Methods
Twelve children (6 to 9 years old) were included. Sessions were held at the hospital twice a week, for 5 weeks. An adapted French version of The Child Simulator Sickness Questionnaire (SSQ) and the Face Scale Pain-Revised (FPS-R) were used to assess pain in the cervical region and undesirable side effects after each session. Vestibular and motor function parameters (active and passive DVA and Movement Assessment Battery for Children–Second Edition, MABC-2) were assessed before and after the training.

Results
All children included completed the 10 sessions. The FPS-R visual analog scale and SSQ showed good cervical tolerance and no oculomotor or vegetative adverse effects nor spatial disorientation. After training, active DVA scores were significantly improved for the right, left, and up directions (p < 0.05). Passive DVA scores were significantly improved for the left and down directions (p < 0.01 and p < 0.05, respectively). MABC-2 scores were improved in the balance and ball skill sections (p < 0.05).

Conclusion
An innovative pediatric training method, the use of a dedicated serious game for gaze stabilization was well-tolerated as a complement to conventional vestibular rehabilitation in children with VH. Moreover, both DVA and motor performance were found to improve in the study sample. Although replication studies are still needed, serious game-based training in children with VH could represent a promising rehabilitation approach for years to come.

Trial registration
The study was conducted in accordance with the Declaration of Helsinki and approved by an Institutional Review Board (local ethics committee, CPP Sud-Est IV, ID 2013–799). The study protocol was registered on ClinicalTrials.gov (NCT04353115).
Traditional knowledge 10 min far from Barcelona: ethnobotanical study in the Llobregat river delta (Catalonia, NE Iberian Peninsula), a heavily anthropized agricultural area
Authors: Marín Jon , Garnatje Teresa , Vallès Joan 
Published: September 2023

AbstractBackgroundThe right floodplain at the Llobregat river delta (Catalonia, NE Iberian Peninsula) constitutes an agricultural periurban area adjacent to Barcelona, which has remained ethnobotanically unexplored until now. This area comprises a very heavily anthropized mosaic of soil uses—urban, industrial, natural, agricultural—including the Agricultural Park of Baix Llobregat. The main aim of this work has been to collect and analyze the ethnoflora of this area in order to fill a gap in the ethnobotanical knowledge in industrialized areas.MethodsThe followed methodology has been based on semi-structured interviews. The obtained data have been qualitatively and quantitatively analyzed and compared with other studies.ResultsData have been gathered from 83 informants. The interviewed informants referred 1965 use reports from 292 taxa, including both non-cultivated and cultivated species, from 85 botanical families. Among those, 451 were referred to medicinal uses, 1247 to food uses and 267 to other uses. In the present study, 779 vernacular names have been reported for 287 taxa. In addition to medicinal and food uses, this study significantly enhances our understanding of some agrosilvopastoral uses of plants, artistic use of plants and insights into folk functional foods. In this regard, we propose a novel quantitative ethnobotany index (the folk functional food index) to assess the relative significance of taxa employed as folk functional foods.ConclusionsThe findings of this study highlight the enduring presence of ethnobotanical knowledge in this periurban agricultural region and underscore the significance of its preservation.
Definitive irradiation as a first treatment strategy for primary and metastatic sites of newly diagnosed IVB cervical cancer that presented with synchronous oligometastases
Authors: Li Junyun , Wang Ying , Huo Lanqing , Huang Xiaodan , Shi Liu , Huang Lin , Chen Kai , Cao Xinping 
Published: September 2023

Abstract
Background
The present study identified survival and progression-free rates and evaluated prognostic factors for IVB stage cervical cancer in patients that presented with synchronous oligometastases (sync-oligometastases) who received definitive irradiation for primary and metastatic sites.

Methods
The study retrospectively included 60 patients with newly diagnosed stage IVB cervical cancer. Patients received definitive radiation for both primary and metastatic sites through Volumetric Modulated Arc Therapy (VMAT) or intensity modulated radiation therapy (IMRT) followed by three dimensional-intracavitary/interstitial brachytherapy at our institution between July 2014 to December 2020. All patients were staged based on the International Federation of Gynecology and Obstetrics (FIGO) 2018 guidelines. Overall survival (OS), progression-free survival (PFS), and patient prognostic factors were analyzed.

Results
The 60 patients who received curative-intent irradiation for primary and metastatic sites showed a 5-year OS rate of 51.4% and a 5-year PFS rate of 25.9%. The median PFS was 52.3 months, and the median OS had not been reached. Lymphatic metastases had a better OS compared with hematogenous metastases (3-year OS rates: 57.2% vs. 20%, p = 0.017). Patients with one metastasis site showed a more favorable prognosis than patients with ≥ 2 metastases sites (3-year OS rates: 60.4% vs. 20.6%, p = 0.003). Patients that presented with tumors larger than 4 cm in diameter before treatment demonstrated a poorer prognosis (5-year OS rates: 41.2% vs. 65.2%, p = 0.029; 5-year PFS rates: 10.4% vs. 53.7%, p = 0.021).

Conclusion
Definitive irradiation for both primary and oligo-metastatic sites for selected IVB patients is a feasible treatment strategy. Metastatic type, number of metastatic sites, and pre-treatment tumor diameter were significant prognostic factors. Neoadjuvant chemotherapy, the lymph nodal metastatic type (supraclavicular or inguinal), and number of lymphatic metastatic sites failed to reach statistical significance as prognostic factors.
Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle
Authors: Pathak Rajesh Kumar , Kim Jun-Mo 
Published: September 2023

Abstract
Background
Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses. Streptococcus agalactiae is a highly virulent bacteria that cause mastitis. The administration of antibiotics for the treatment of this infection is not advised due to concerns about the emergence of antibiotic resistance and potential adverse effects on human health. Thus, there is a critical need to identify new therapeutic approaches to combat mastitis. One promising target for the development of antibacterial therapies is the transmembrane histidine kinase of bacteria, which plays a key role in signal transduction pathways, secretion systems, virulence, and antibiotic resistance.

Results
In this study, we aimed to identify novel natural compounds that can inhibit transmembrane histidine kinase. To achieve this goal, we conducted a virtual screening of 224,205 natural compounds, selecting the top ten based on their lowest binding energy and favorable protein–ligand interactions. Furthermore, molecular docking of eight selected antibiotics and five histidine kinase inhibitors with transmembrane histidine kinase was performed to evaluate the binding energy with respect to top-screened natural compounds. We also analyzed the ADMET properties of these compounds to assess their drug-likeness. The top two compounds (ZINC000085569031 and ZINC000257435291) and top-screened antibiotics (Tetracycline) that demonstrated a strong binding affinity were subjected to molecular dynamics simulations (100 ns), free energy landscape, and binding free energy calculations using the MM-PBSA method.

Conclusion
Our results suggest that the selected natural compounds have the potential to serve as effective inhibitors of transmembrane histidine kinase and can be utilized for the development of novel antibacterial veterinary medicine for mastitis after further validation through clinical studies.
A comparison of the effects of occupation-based interventions with and without responsibility feedback and conventional interventions on participation in people with idiopathic Parkinson’s disease: study protocol for a randomized controlled trial
Authors: Meimandi Mahsa , Azad Akram , Ghani Jafar Haj , HojabriFard Fatemeh , von Rosen Philip , Alizadeh Naeeme Haji , Taghizadeh Ghorban 
Published: September 2023

Abstract
Background
Parkinson’s disease (PD) is a neurodegenerative disorder with debilitating motor and non-motor symptoms which affect participation in meaningful occupations. Occupation-based interventions can improve participation in people with PD. Evidence for incorporating structured and intensive occupational therapy by considering the concept of responsibility is lacking for this population. This trial will compare the effects of occupation-based interventions with and without responsibility feedback and conventional interventions on participation in people with idiopathic PD.

Methods
A total of 45 people with PD, between 35 and 85 years old and Hoehn and Yahr stages between I to III, will be recruited from movement disorder centers for this three-armed study. Participants will be randomized into three groups (occupation-based interventions with responsibility feedback, occupation-based interventions without responsibility feedback, and conventional interventions). All participants will receive intervention for 24 sessions during a period of 12 weeks (2 sessions per week). The primary outcome measure will be participation satisfaction. Participation frequency and restriction, self-perceived performance, performance satisfaction, motivation, volition, sense of agency, responsibility, physical activity, community integration, activities of daily living (ADL), instrumental ADL, upper extremity function, balance, fatigue, and quality of life will be measured as secondary outcome measures. All outcomes will be measured at baseline, session 9, session 17, post-intervention (week 13), and follow-up (week 25).

Discussion
This home-based high-intensity, structured, client-centered, and occupation-based intervention will be conducted by utilizing the concept of responsibility. This proposed trial may result in enhanced participation that would benefit other motor and non-motor symptoms in people living with PD. Findings from this proposed study are expected to expand the knowledge of clinicians and help them in evidence-based decision-making processes.

Trial registration
Iranian Registry of Clinical Trials IRCT20140304016830N13. Registered on August 19, 2022
A randomised controlled trial in preterm infants comparing prophylactic with selective “less invasive surfactant administration” (pro.LISA)
Authors: Göpel Wolfgang , Rausch Tanja K. , Mitschdörfer Barbara , Mader Silke , Herting Egbert , König Inke R. , Stichtenoth Guido ,   on behalf of the pro.LISA study group, Höhn Thomas , Stein Anja , Bayer Hagen , Schmidtke Susanne , Naust Barabara , Roll Claudia , Franz Axel , Wolff Moritz , Siemes Anna , Schneider Katja , Dieks Jana Katharina , Fuchs Hans , Körner Thorsten , Schroth Michael , Dohle Frank , Völkl Thomas , Härtel Christoph , Bejo Levente , Schneider Welfhard 
Published: September 2023

Abstract
Background
Respiratory distress syndrome is the main cause of mortality and morbidity in preterm infants. “Less invasive surfactant administration” (LISA), which describes intratracheal surfactant administration to spontaneously breathing infants via a small diameter tube, is recommended as the first-line treatment in preterm infants with more than 30% supplemental oxygen. Prophylactic use of LISA in preterm infants with less than 30% supplemental oxygen was not tested in randomised controlled trials yet, and long-term outcome data of the procedure are scarce.

Methods
Preterm infants with a gestational age between 25 weeks + 0 days and 28 weeks + 6 days who are breathing spontaneously on continuous positive airway pressure with supplemental oxygen at or below 30% in the first hour of life will be randomised to a prophylactic LISA treatment with 100–200 mg surfactant intratracheally per kilogramme bodyweight (intervention group) or will continue the continuous positive airway pressure treatment (control group). Participants will have follow-up until age 5 years. At that time, the children will be tested by spirometry, and forced expiratory volume within 1-s z-scores will be compared between the intervention and control groups as the primary outcome parameter of the trial. Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious lung diseases. Short-term safety assessment will be done after completed enrolment (n = 698) and discharge of all infants. This safety assessment will include in-hospital mortality and short-term complications.

Discussion
Robust data concerning the possible long-term benefits of prophylactic LISA treatment are lacking. The current observational data from the German Neonatal Network indicate that approximately 50% of preterm infants with supplemental oxygen at or below 30% within the first hour of life are treated with LISA. The pro.LISA trial will provide short- and long-term outcomes of preterm infants receiving prophylactic treatment and will clarify if prophylactic treatment should be given to all preterm infants or if the current practice of selective treatment if supplemental oxygen exceeds 30% is more appropriate.

Trial registration
German Clinical Trials Register DRKS00028086. Prospectively registered on 8 February 2022.
A health-risk assessment method for the preventive protection of metal cultural relics using improved rank correlation analysis and AHP fuzzy synthetic evaluation
Authors: Li Dandan , Zhou Hao , Xu Fangyuan , Yan Ying , Wu Laiming , Cai Lankun 
Published: September 2023

Abstract
This paper presents an innovative health-risk assessment methodology for the preventive protection of metal cultural relics in museums, which is based on the improved rank correlation analysis and AHP fuzzy synthetic evaluation (Relics—AHP—FSE). The approach combines the established ABC method for analyzing the pertinent environmental risk level. In this study, metal cultural relics are introduced as the research subjects. Based on the current scientific knowledge and requirements reported in international norms, a three-level index framework for assessing the health-risk is established in a hierarchical manner, and the quantitative indicators with typical correlations are proposed. The Relics—AHP—FSE approach is applied to the results of the 2022 temporary exhibition “Zhaizi China: Henan Xia, Shang and Zhou Dynasties civilization exhibition” of Shanghai Museum (China), a renowned institution boasting a significant collection of invaluable relics. In addition, the study accomplishes a scientific and practical health-risk assessment of relics. By utilizing online monitoring data and employing the expert judgment method, this study presents a comprehensive method for assessing the health-risk of metal cultural relics efficiently and conveniently. This cultural heritage protection method is specifically for safeguarding cultural relics exhibited in museums, developed in close collaboration with conservation scientists.
A systematic review of repeatability and reproducibility studies of diffusion tensor imaging of cervical spinal cord
Authors: Al-shaari Hussein , J Fulford , R Meertens , CJ Heales 
Published: September 2023

Objectives: Diffusion tensor imaging (DTI) techniques are being studied as a possible diagnostic and predictive tool for the evaluation of cervical spinal cord disease. This systematic review aims to evaluate the previous DTI studies that specifically investigated the repeatability and reproducibility of DTI in the cervical spinal cord. Methods and materials: A search in the PubMed, Scopus, Web of Science and Ovid electronic databases was conducted for articles published between January 1990 and February 2022 that related to the repeatability and reproducibility of DTI in evaluating the cervical spinal cord using one of the following measurements: the intraclass correlation coefficient (ICC) and/or the coefficient of variation (CV), and/or Bland-Altman (BA) differences analysis methods. DTI studies that presented full statistical analysis of repeatability and/or reproducibility tests of the cervical spinal cord in peer-reviewed full-text publications published in journals were included. Articles that included at least one of the keywords within the titles or abstracts were identified. Additional full-text papers were found by searching the citations and reference lists of related articles. This review has followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance. Risk of bias was evaluated with 13 criteria weighted toward methodological quality of reported studies using the QuADS assessment criteria. This assessment only included full-text articles written in English. Results: A total of 11 studies were included and assessed for different characteristics, including sample size,(3–34) re-test time interval (<1 h to >3 months), test-retest reproducibility scores and acquisition method. Six studies used ICC which ranged from poor (ICC<0.37) to excellent reproducibility (ICC 0.91–0.99). Four studies reported an overall CV lower than 40% for all DTI metrics. Three studies reported the Bland-Altman (BA) differences and reported a minimum percentage showing no strong differences between repeated measurements. Quantitative analysis was not undertaken due to heterogeneity of methods. Repeatability and reproducibility measures were generally found to be good. Conclusion: This study revealed that the application of DTI and its related measures in a clinical setting in the assessment of cervical spinal cord changes is feasible and reproducible. However, cervical spinal cord DTI suffers from some existing limitations that prevent it from being routinely used in research and clinical settings. Advances in knowledge: DTI with its parametric maps provide broad evaluation of the tissue structure of axonal white matter and are being studied as a possible diagnostic and predictive tool for the assessment of cervical spinal cord (CSC) disease.
ChatGPT: a tool for scientific writing or a threat to integrity?
Authors: Silva Thaísa Pinheiro , Ocampo Thaís S C , Alencar-Palha Caio , Oliveira-Santos Christiano , Takeshita Wilton Mitsunari , Oliveira Matheus L 
Published: September 2023

Abstract
The use of ChatGPT as a tool for writing and knowledge integration raises concerns about the potential for its use to replace critical thinking and academic writing skills. While ChatGPT can assist in generating text and suggesting appropriate language, it should not replace the human responsibility for creating innovative knowledge through experiential learning. The accuracy and quality of information provided by ChatGPT also require caution, as previous studies have reported inaccuracies in references used by chatbots. ChatGPT acknowledges certain limitations, including the potential for generating erroneous or biased content, and it is essential to exercise caution in interpreting its responses and recognize the indispensable role of human experience in the processes of information retrieval and knowledge creation. Furthermore, the challenge of distinguishing between papers written by humans or AI highlights the need for thorough review processes to prevent the spread of articles that could lead to the loss of confidence in the accuracy and integrity of scientific research. Overall, while the use of ChatGPT can be helpful, it is crucial to raise awareness of the potential issues associated with the use of ChatGPT, as well as to discuss boundaries so that AI can be used without compromising the quality of scientific articles and the integrity of evidence-based knowledge.