bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal of Bacteria from Air and Aqueous Phase Based on N‐Halamine Decorated Polyacrylonitrile Nanofiber Membrane
Authors: Wang Yingfeng , Zhang Wenya , Hong Jun , Xia Yuting , Zhu Yuhan , Yang Gun , Yin Maoli , Li Wei , Ma Zhipeng , Xu Zhenzhen 
Published: June 2023

AbstractMicrobial contamination of water and air requires novel filtration materials. Here, the disinfecting, nonbleaching compounds 1,3‐dichloro‐5,5‐dimethylhydantoin (DCDMH) and 1‐bromo‐3‐chloro‐5,5‐dimethyl hydantoin (BCDMH) were combined with PAN polymers via electrospinning for antimicrobial filtration. The resulting nanofibrous membranes (PAN/DCDMH and PAN/BCDMH) were fully characterized by SEM, EDS, FTIR, TG, and XPS. Antimicrobial activities of the tested membranes were challenged with E.coli O157:H7 and S.aureus in the aqueous and bioaerosols phase, using the colony counting method. Both types of embedded membranes showed excellent antimicrobial properties upon exposure to bacteria solution and aerosol, and all bacteria were quickly inactivated. The anti‐biofilm activity of embedded membranes was excellent after being treated with bacteria solution for 48 h. In addition, N‐chloramine displayed lower halogen loss than N‐bromamines in air and aqueous conditions. Both DCDMH and BCDMH embedded nanofibrous membranes showed great potential as filtration materials to remove microorganisms from aqueous and air conditions.
Engaging Diastereomeric syn‐ and anti‐6‐Bromo‐4a‐isopropyl‐2‐methyl‐2,3,4,4a‐tetrahydro‐1H‐carbazoles in Suzuki Coupling Reaction: Synthesis, Spectral Characterization and DFT Studies
Authors: Younus Munisaa , Khan Maria Aqeel , Moin Syed Tarique , Basha Fatima Zehra 
Published: June 2023

AbstractSuzuki coupling reaction is one of the useful methods for carbon‐carbon bond formation. In the present study, the aforementioned method is used to expand an aryl appendage on the indolenine nucleus of diastereomeric syn‐ and anti‐6‐bromo‐4a‐isopropyl‐2‐methyl‐2,3,4,4a‐tetrahydro‐1H‐carbazole analogs. Therefore, two sets of new diastereomeric Suzuki‐coupled products (16 compounds) were prepared. For this, diastereomeric syn‐ and anti‐6‐bromo‐4a‐isopropyl‐2‐methyl‐2,3,4,4a‐tetrahydro‐1H‐carbazole analogs were treated with arylboronic acids in the presence of palladium catalyst under thermal catalysis. Structures of synthesized compounds were inferred using spectroscopic studies. DFT‐based quantum chemical calculations were used to decipher structural attributes and stability of diastereomeric bromo‐2,3,4,4a‐tetrahydro‐1H‐carbazoles and their Suzuki‐coupled products, which revealed chair conformation for methylcyclohexane ring of syn‐compound while twist‐boat conformation for diastereomeric anti‐compound. syn‐Compound was found more stable than its anti‐isomer based on DFT‐calculations. Also, results demonstrated agreement between experimental and theoretical chemical shift values in NMR spectra with some deviations. Thus, structural elucidation based on computational advances in combination with the spectroscopic method can provide a powerful method for studying and comparing the structural attributes of diastereomeric compounds.
Performance Comparison of Paper‐ and Cotton‐Based Al‐Air Batteries without Catalysts for Low‐Cost Portable Micro Devices
Authors: Liu Chun‐mei , Liu Jing‐jie , Xu Li‐you , Jiang Peng‐fei , Chen Meng 
Published: June 2023

AbstractConventional Al‐air batteries are not suitable as portable power devices due to their complicated water management and bulky system. To resolve this issue, the fiber paper‐ and cotton cloth‐based Al‐air batteries were proposed, which exploited the capillary force from the paper (FP) and cotton cloth (CC) to deliver the solutions and eliminated the external pump. The physical features of the FP and CC were gained including the surface morphologies, surface elementary analysis, liquid absorption and flow rates. CC owned larger liquid absorption and faster flow rate due to its hierarchically woven‐spun fiber structure, compared to the randomly oriented fibers of the FP, although the surface of the CC demonstrated lower O/C ratio than that of the FP. So, the performance of the CC‐based Al‐air battery was largely higher than that of the FP‐based battery. The performance of the CC‐based Al‐air battery was optimal at 1.0 M NaOH electrolyte and the anode‐to‐cathode surface area ratio of 1 : 4, with the peak power density of 14.95±0.28 mW cm−2, and the maximum current density of 36.61±0.54 mA cm−2. To apply the CC‐based Al‐air battery, the two‐battery pack connected in series was assembled to drive a timer and light 9 LEDs.
N‐Chlorosuccinimide Mediated Direct C−H Thiocyanation of 1‐Aryl‐5‐pyrazolones at Room Temperature
Authors: Prajapati Ronak V. , Prajapati Vaibhav D. , Purohit Vishal B. , Andre Baptista Luis , Avalani Jemin R. , Sapariya Nirav H. , Karad Sharad C. , Raval Dipak K. 
Published: June 2023

AbstractA facile synthetic protocol has been established for the N‐chlorosuccinimide (NCS) promoted direct C−H thiocyanation of 1‐aryl‐5‐pyrazolones via in situ‐generated electrophilic thiocyanating agent at room temperature. The current protocol features easy performance, mild conditions and short reaction time using readily available starting materials. The DFT studies suggested that ionic process is likely to be involved in this transformation yielding the targeted product with the most stable enaminone form as the favoured tautomer.
Tropylium‐BF4as Organocatalyst for Microwave‐assisted Beckmann rearrangement in [TMG][BF4]: One‐pot conversion of Ketones to Amides
Authors: Anchi Athmanand , Kalkhambkar Rajesh G. , Sutar Suraj M. , Naik Ravi S. , Refat Moamen S. , Adam Abdel Majid A. , Mohammed Alsuhaibani Amnah 
Published: June 2023

AbstractThe microwave assisted one pot efficient conversion of ketones into respective amides has been achieved by utilization of environmentally benign catalytic system tailored by tropylium tetrafluoroborate (Tp+BF−4) and 1,1,3,3‐tetramethylguanidinium tetrafluoroborate [TMG][BF4]. The mild reaction conditions, shorter reaction time, and affordable catalytic system are the key points that highlight the importance. The high product yield and ease of recycling impacts the successful product conversion.
Light‐touch integration: A study on cross‐border acquisitions by emerging market multinationals
Authors: Tang Lisa , Zhao Minyuan 
Published: June 2023

AbstractResearch SummaryEmerging‐market multinational enterprises (EMNEs) are known for their “light‐touch” integration after cross‐border acquisitions. That is, compared with their developed‐country counterparts, EMNEs are more likely to retain the top management team (TMT) of the target firms. In this paper, we argue that this difference in retention rate can be explained by country, cohort, and firm effects. While the literature mostly associates EMNEs with where they are from (country effect), EMNEs are also new to cross‐border acquisitions (firm effect) and among the first in their peers to venture abroad (cohort effect). Analysis on a sample of 1862 absorption‐type cross‐border acquisitions supports our hypotheses that while the country effect persists, the difference in retention rate narrows significantly as EMNEs and their peers gain more relevant cross‐border acquisition experience.Managerial SummaryThe retention of top management team in target firms is a critical aspect of post‐acquisition integration (PAI). In this study, we examine the reasons behind the curious observation that, compared with acquirers from developed countries, multinational enterprises from emerging markets (EMNEs) are more likely to keep the target firm TMT intact, even in deals where extensive integration is in line with the overall acquisition objectives. Our analyses show that the legitimacy constraints associated with EMNEs' less developed home countries indeed present initial challenges to their integration efforts. However, these differences narrow significantly as EMNEs and their peers accumulate more experience in similar cross‐border acquisitions. This study highlights the dynamic nature of PAI strategies and the large variance among firms beneath the “EMNE” label.
Review of the legal and regulatory history of lead in hunting
Authors: Byrne Robert 
Published: June 2023

AbstractIn the United States, regulations to restrict the use of lead in ammunition have evolved at both the federal and state levels since lead shot was banned for hunting waterfowl nationwide by federal regulation in 1991. Prior to 1991, most of the effort and discussions were focused on reducing lead ingestion by wildlife from, and finding alternatives for, shotgun ammunition i.e., ammunition firing multiple small projectiles from one shell. Shotgun ammunition is often used for hunting small game mammals and birds. Since then, much, but not all, of the focus has shifted to reducing lead ingestion by wildlife from, and finding alternatives for, rifle ammunition i.e., ammunition firing a single projectile. Rifle ammunition is often, but not exclusively, used for hunting large game. Herein I will review the history of regulating lead in hunting ammunition in the U.S., and discuss some of the social, scientific, economic, and technological issues regarding switching from lead to nonlead alternatives.
Evaluation of the Recent African Gravity Databases V2.x
Authors: Abd-Elmotaal Hussein A. , Kühtreiber Norbert , Seitz Kurt , Heck Bernhard , Kutterer Hansjörg 
Published: June 2023

AbstractIn the framework of the activities of the IAG Sub-Commission on the gravity and geoid in Africa, a recent set of gravity databases has been established. They are namely: AFRGDB_V2.0 and AFRGDB_V2.2. The AFRGDB_V2.0 has been created using the window remove-restore technique employing EGM2008 as geopotential Earth model complete to degree and order 1800. The AFRGDB_V2.2 has been established using the Residual Terrain Model (RTM) reduction technique employing GOCE DIR_R5 complete to degree and order 280, using the best RTM reference surface. The available gravity data set for Africa, used to establish the above mentioned two independently derived databases, consists of shipborne, altimetry derived gravity anomalies and of land point gravity data. In particular, the data set of point gravity values shows clear deficits with regard to a homogeneous data coverage over the completely African continent. The establishment of the gravity databases has been carried-out using the weighted least-squares prediction technique, in which the point gravity data on land has got the highest precision, while the shipborne and altimetry gravity data got a moderate precision. In this paper a new gravity data set on land and on sea, which became recently available for the IAG Sub-Commission on the gravity and geoid in Africa, located partly in the gap areas of the data set used for generating the gravity databases, has been employed to evaluate the accuracy of the previously created gravity databases. The results show reasonable accuracy of the established gravity databases considering the large data gaps in Africa.
Color superconductivity on the lattice — analytic predictions from QCD in a small box
Authors: Yokota Takeru , Ito Yuta , Matsufuru Hideo , Namekawa Yusuke , Nishimura Jun , Tsuchiya Asato , Tsutsui Shoichiro 
Published: June 2023

Abstract
We investigate color superconductivity on the lattice using the gap equation for the Cooper pair condensate. The weak coupling analysis is justified by choosing the physical size of the lattice to be smaller than the QCD scale, while keeping the aspect ratio of the lattice small enough to suppress thermal excitations. In the vicinity of the critical coupling constant that separates the superconducting phase and the normal phase, the gap equation can be linearized, and by solving the corresponding eigenvalue problem, we obtain the critical point and the Cooper pair condensate without assuming its explicit form. The momentum components of the condensate suggest spatially isotropic s-wave superconductivity with Cooper pairs formed by quarks near the Fermi surface. The chiral symmetry in the massless limit is spontaneously broken by the Cooper pair condensate, which turns out to be dominated by the scalar and the pseudo-scalar components. Our results provide useful predictions, in particular, for future lattice simulations based on methods to overcome the sign problem such as the complex Langevin method.
Analytic approximations of 2 → 2 processes with massive internal particles
Authors: Davies Joshua , Mishima Go , Schönwald Kay , Steinhauser Matthias 
Published: June 2023

Abstract
We consider two-loop corrections to 2 → 2 scattering processes with massive particles in the final state and massive particles in the loop. We discuss the combination of analytic expansions in the high-energy limit and for small Mandelstam variable t. For the example of double Higgs boson production we show that the whole phase space can be covered and time-consuming numerical integrations can be avoided.
von Neumann algebras in JT gravity
Authors: Kolchmeyer David K. 
Published: June 2023

Abstract
We quantize JT gravity with matter on the spatial interval with two asymptotically AdS boundaries. We consider the von Neumann algebra generated by the right Hamiltonian and the gravitationally dressed matter operators on the right boundary. We prove that the commutant of this algebra is the analogously defined left boundary algebra and that both algebras are type II∞ factors. These algebras provide a precise notion of the entanglement wedge away from the semiclassical limit. We comment on how the factorization problem differs between pure JT gravity and JT gravity with matter.
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
Authors: Geraldo Luiz Henrique , Garcia Celina , Xu Yunling , Leser Felipe Saceanu , Grimaldi Izabella , de Camargo Magalhães Eduardo Sabino , Dejaegher Joost , Solie Lien , Pereira Cláudia Maria , Correia Ana Helena , De Vleeschouwer Steven , Tavitian Bertrand , Canedo Nathalie Henriques Silva , Mathivet Thomas , Thomas Jean-Leon , Eichmann Anne , Lima Flavia Regina Souza 
Published: June 2023

AbstractGlioblastoma (GBM) is the most common and fatal primary tumor of the central nervous system (CNS) and current treatments have limited success. Chemokine signaling regulates both malignant cells and stromal cells of the tumor microenvironment (TME), constituting a potential therapeutic target against brain cancers. Here, we investigated the C–C chemokine receptor type 7 (CCR7) and the chemokine (C–C-motif) ligand 21 (CCL21) for their expression and function in human GBM and then assessed their therapeutic potential in preclinical mouse GBM models. In GBM patients, CCR7 expression positively associated with a poor survival. CCL21–CCR7 signaling was shown to regulate tumor cell migration and proliferation while also controlling tumor associated microglia/macrophage recruitment and VEGF-A production, thereby controlling vascular dysmorphia. Inhibition of CCL21–CCR7 signaling led to an increased sensitivity to temozolomide-induced tumor cell death. Collectively, our data indicate that drug targeting of CCL21–CCR7 signaling in tumor and TME cells is a therapeutic option against GBM.
Transition Amplitudes in 3D Quantum Gravity: Boundaries and Holography in the Coloured Boulatov Model
Authors: Goeller Christophe , Oriti Daniele , Schmid Gabriel 
Published: June 2023

AbstractWe consider transition amplitudes in the coloured simplicial Boulatov model for three-dimensional Riemannian quantum gravity. First, we discuss aspects of the topology of coloured graphs with non-empty boundaries. Using a modification of the standard rooting procedure of coloured tensor models, we then write transition amplitudes systematically as topological expansions. We analyse the transition amplitudes for the simplest boundary topology, the 2-sphere, and prove that they factorize into a sum entirely given by the combinatorics of the boundary spin network state and that the leading order is given by graphs representing the closed 3-ball in the large N limit. This is the first step towards a more detailed study of the holographic nature of coloured Boulatov-type GFT models for topological field theories and quantum gravity.
Best-response dynamics, playing sequences, and convergence to equilibrium in random games
Authors: Heinrich Torsten , Jang Yoojin , Mungo Luca , Pangallo Marco , Scott Alex , Tarbush Bassel , Wiese Samuel 
Published: June 2023

AbstractWe analyze the performance of the best-response dynamic across all normal-form games using a random games approach. The playing sequence—the order in which players update their actions—is essentially irrelevant in determining whether the dynamic converges to a Nash equilibrium in certain classes of games (e.g. in potential games) but, when evaluated across all possible games, convergence to equilibrium depends on the playing sequence in an extreme way. Our main asymptotic result shows that the best-response dynamic converges to a pure Nash equilibrium in a vanishingly small fraction of all (large) games when players take turns according to a fixed cyclic order. By contrast, when the playing sequence is random, the dynamic converges to a pure Nash equilibrium if one exists in almost all (large) games.
The effects of hydrocortisone and yohimbine on human behavior in approach-avoidance conflicts
Authors: Fricke Kim , Alexander Nina , Jacobsen Thomas , Krug Henriette , Wehkamp Kai , Vogel Susanne 
Published: June 2023

Abstract
Rationale
Balancing approach of positive and avoidance of negative stimuli is essential when faced with approach-avoidance conflicts, e.g., situations with both positive and negative outcomes. This balance is disturbed in several mental disorders, e.g., excessive avoidance in anxiety disorders, and heightened approach in substance use disorders. Since stress is assumed to impact these disorders’ etiology and maintenance, it seems crucial to understand how stress influences behavior in approach-avoidance conflicts. Indeed, some studies suggested altered approach-avoidance behavior under acute stress, but the mechanism underlying these effects is unknown.

Objectives
Investigate how the pharmacological manipulation of major stress mediators (cortisol and noradrenaline) influences task-based approach-avoidance conflict behavior in healthy individuals.

Methods
Ninety-six participants (48 women, 48 men) received either 20mg hydrocortisone, 20mg yohimbine, both, or placebo before performing a task targeting foraging under predation in a fully crossed double-blind between-subject design. Moreover, we investigated effects of gender and endogenous testosterone and estradiol levels on approach-avoidance behavior.

Results
While biological stress markers (cortisol concentration, alpha amylase activity) indicated successful pharmacological manipulation, behavior in approach-avoidance conflicts was not affected as expected. Although yohimbine administration affected risky foraging latency under predation, we found no main effect of hydrocortisone or their interaction on behavior. In contrast, we found gender differences for almost all behavioral outcome measures, which might be explained by differences in endogenous testosterone levels.

Conclusions
The investigated major stress mediators were not sufficient to imitate previously shown stress effects on approach-avoidance conflict behavior. We discuss potential reasons for our findings and implications for future research.
Determinants on urinary excretion of oxalate and other key factors related to urolithiasis among patients with chronic kidney disease: a single center study
Authors: Bao Daorina , Zhang Huimin , Wang Jinwei , Wang Yu , Wang Suxia , Zhao Ming-hui 
Published: June 2023

Abstract
Purpose
Urolithiasis is a known risk factor for chronic kidney disease (CKD). However, how CKD might affect the risk of incidence of urolithiasis is not widely studied.

Methods
Urinary excretion of oxalate as well as other key factors related to urolithiasis was analyzed in a single center study of 572 patients with biopsy-proven kidney disease.

Results
The mean age of the cohort was 44.9 years and 60% were males. The mean eGFR was 65.9 ml/min/1.73 m2. Median urinary excretion of oxalate was 14.7 (10.4–19.1) mg/24-h and associated with current urolithiasis (OR 12.744, 95% CI: 1.564–103.873 per one logarithm transformed unit of urinary oxalate excretion). Oxalate excretion was not associated with eGFR and urinary protein excretion. Oxalate excretion was higher in patients with ischemia nephropathy as compared with patients with glomerular nephropathy and tubulointerstitial nephropathy (16.4 vs 14.8 vs 12.0 mg, p = 0.018). And ischemia nephropathy (p = 0.027) was associated with urinary oxalate excretion on adjusted linear regression analysis. Urinary excretion of calcium and uric acid was correlated with eGFR and urinary protein excretion (all p < 0.001), with ischemia nephropathy and tubulointerstitial nephropathy associated with uric acid excretion (both p < 0.01) as well. Citrate excretion was correlated with eGFR (p < 0.001) on adjusted linear regression.

Conclusion
Excretion of oxalate and other key factors related to urolithiasis was differentially associated with eGFR, urinary protein, and pathological changes in CKD patients. The influence of these intrinsic traits of the underlining kidney disease should be considered when evaluating urolithiasis risk in patients with CKD.
A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation
Authors: Piha-Paul Sarina A. , Tseng Chieh , Tran Hai T. , Gao Meng , Karp Daniel D. , Subbiah Vivek , Tsimberidou Apostolia Maria , Kawedia Jitesh D. , Fu Siqing , Pant Shubham , Yap Timothy A. , Morris Van K. , Kee Bryan K. , Blum Murphy Mariela , Lim JoAnn , Meric-Bernstam Funda 
Published: June 2023

Abstract
Purpose

Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberrant or compensatory mechanisms. Herein, we sought to determine the feasibility and safety of neratinib and trametinib in patients with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation and KRAS mutation.

Methods

Patients with actionable somatic mutations or amplifications in ERBB genes or actionable KRAS mutations were enrolled to receive neratinib and trametinib in this phase I dose escalation trial. The primary endpoint was determination of the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). Secondary endpoints included pharmacokinetic analysis and preliminary anti-tumor efficacy.

Results

Twenty patients were enrolled with a median age of 50.5 years and a median of 3 lines of prior therapy. Grade 3 treatment-related toxicities included: diarrhea (25%), vomiting (10%), nausea (5%), fatigue (5%) and malaise (5%). The MTD was dose level (DL) minus 1 (neratinib 160 mg daily with trametinib 1 mg, 5 days on and 2 days off) given 2 DLTs of grade 3 diarrhea in DL1 (neratinib 160 mg daily with trametinib 1 mg daily). The treatment-related toxicities of DL1 included: diarrhea (100%), nausea (55.6%) and rash (55.6%). Pharmacokinetic data showed trametinib clearance was significantly reduced leading to high drug exposures of trametinib. Two patients achieved stable disease (SD) ≥ 4 months.

Conclusion
Neratinib and trametinib combination was toxic and had limited clinical efficacy. This may be due to suboptimal drug dosing given drug–drug interactions.
Trial registration ID: NCT03065387.