bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gewinn oder neue Hürde im politischen Alltag? Sprachreflexion als Element politischer Kommunikation und gegenwärtige Herausforderung (1949–2021)
Authors: Klammer Kristoffer 
Published: July 2023

Zusammenfassung
In den vergangenen sieben Jahrzehnten hat die Sprachsensibilität in – auch tagesaktuellen – politischen Debatten beständig zugenommen. Heute, so die Kernthese des Aufsatzes, müssen Argumente, um politisch bestehen und Erfolg zeitigen zu können, permanent dagegen abgesichert werden, sprachreflexiv angreifbar zu sein. Die Studie skizziert zunächst wichtige zeithistorische Entwicklungen, die zu diesem Maß an Sprachreflexion beigetragen haben, und zeigt auf, inwieweit sich dabei (bundes-)deutsche Spezifika und transnational wirkmächtige Entwicklungen miteinander verzahnten. Dazu synthetisiert sie zielgerichtet Einzelergebnisse eigener historisch-semantischer Forschungen sowie zahlreicher kommunikationsgeschichtlicher Arbeiten aus Geschichts- und Sprachwissenschaften. Sodann überführt der Aufsatz die Argumentation von einer zeithistorischen in eine Gegenwartsanalyse; sie fußt auf einem Korpus an Quellen aus den Jahren 2010 bis 2021, das Printmedien genauso berücksichtigt wie Webportale mit dezidiert politischen Inhalten. Hier fragt und diskutiert der Aufsatz, mit welchen neuen Herausforderungen sich Politikerinnen und Politiker infolge des weiter gewachsenen Ausmaßes und neuer Formen der Sprachsensibilität aktuell konfrontiert sehen. In der Summe strebt der Beitrag mithin einen zeithistorisch informierten Blick auf ein Gegenwartsphänomen (in) der politischen Kommunikation an, der zugleich als Diskussionsanregung in gegenwartsanalytischer Absicht gedacht ist.
A simple protocol for isolating microglia from adult mouse brain
Authors: Chakrabarti Sudipta , Gorai Sukhamoy , Pahan Kalipada 
Published: August 2023

Abstract

Objectives
Although microglia are activated in adult and aged brains resulting in neurodegenerative and neuroinflammatory disorders, most of the cell culture studies on microglia deal with neonatal microglia because of ease of isolation. Microglia could be isolated from adult brains, but it requires separation by density gradient centrifugation, magnetic beads, etc. Here, we describe a simple protocol of isolating highly purified microglia from adult mouse brains.

Methods
Our protocol involves dilution with sterile PBS or media, regular centrifugation, and plating on poly-D-lysine-coated flasks.

Results
These adult microglia expressed the inducible nitric oxide synthase in response to preformed α-syn fibril, an etiological reagent of Parkinson’s disease, and bacterial lipopolysaccharides, one of the prototype proinflammatory stimuli. Moreover, these adult microglia exhibited phagocytosis, which was stimulated by LPS treatment.

Conclusions
These results suggest that adult microglia isolated by our procedure are functional and that these adult microglia could be used for studies related to neurodegenerative disorders.
Investigation of the mechanical properties, surface quality, and energy efficiency of a fused filament fabrication for PA6
Authors: Mushtaq Ray Tahir , Wang Yanen , Rehman Mudassar , Khan Aqib Mashood , Bao Chengwei , Sharma Shubham , Eldin Sayed M. , Abbas Mohamed 
Published: August 2023

Abstract
Practitioners in the industry are developing predictive methods for assessing key parameters and responses of engineering materials. The aim of this research is to optimize the average surface roughness (R
a), flexural strength (FS), tensile strength (TS), print time (T), and print energy consumption (E) of 3D printed Nylon 6 (PA6). Quantitative parameters for infill density (ID), layer thickness (LT), and print speed (PS) were selected. Employing the central component design (CCD)-response surface methodology (RSM) for investigational design, statistical analysis, and multi-objective optimization, a total of 20 samples were produced and analyzed to develop prediction models. The implication of the selected parameters was confirmed through variance analysis (ANOVA), and the models were validated using confirmatory trial tests. It was found that LT was essential in achieving appropriate R
a and T values, while ID was a crucial factor in obtaining the necessary mechanical properties. RSM optimization led to an FS of 70.8 MPa, TS of 40.8 MPa, lowest T of 53 min, lowest possible R
a of 8.30 µm, and 0.203 kW·h “E” at ID = 84%, LT = 0.21 mm, and PS = 75 mm·s−1. The study also revealed weak bond strength between layers and layers debonding after bending tests, as shown in SEM micrographs. The PA6 material exhibited flexibility during tensile testing, going into plasticity before breaking. The created numerically optimized model is anticipated to benefit manufacturers and practitioners in predicting the required surface quality for various factors before conducting experiments, ultimately improving 3D printing (3DP) processes and outcomes. Despite limitations such as limited parameter selection, small sample size, and material-specific focus, this research presents valuable insights for the 3DP industry.
Satellite RNAs: emerging players in subnuclear architecture and gene regulation
Authors: Ninomiya Kensuke , Yamazaki Tomohiro , Hirose Tetsuro 
Published: August 2023

AbstractSatellite DNA is characterized by long, tandemly repeated sequences mainly found in centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to‐telomere sequencing data revealed the complete sequences of satellite regions, including centromeric α‐satellites and pericentromeric HSat1–3, which together comprise ~ 5.7% of the human genome. Despite possessing constitutive heterochromatin features, these regions are transcribed to produce long noncoding RNAs with highly repetitive sequences that associate with specific sets of proteins to play various regulatory roles. In certain stress or pathological conditions, satellite RNAs are induced to assemble mesoscopic membraneless organelles. Specifically, under heat stress, nuclear stress bodies (nSBs) are scaffolded by HSat3 lncRNAs, which sequester hundreds of RNA‐binding proteins. Upon removal of the stressor, nSBs recruit additional regulatory proteins, including protein kinases and RNA methylases, which modify the previously sequestered nSB components. The sequential recruitment of substrates and enzymes enables nSBs to efficiently regulate the splicing of hundreds of pre‐mRNAs under limited temperature conditions. This review discusses the structural features and regulatory roles of satellite RNAs in intracellular architecture and gene regulation.
Analysis of indications of induction of labor and feto-maternal outcome in a tertiary care hospital
Authors: Sharma Shuchi , Sharma Reena , Gautam Ankush 
Published: July 2023

Background: Induction of labor (IOL) is an intervention that artificially initiates uterine contractions leading to progressive dilatation and effacement of cervix and expulsion of fetus prior to spontaneous onset of labor. Aim of study was to study the indications of induction of labor and the feto-maternal outcome.
Methods: Women who underwent IOL beyond 28 weeks gestation with single cephalic presentation were included in the study over a period of one year.
Results: A total of 3887 women delivered in the hospital during the study period. 1107 (28.47%) pregnant women underwent induction of labor. Most common indication of induction of labor was post-date pregnancy 682 (61.60%). About 64.52% had vaginal delivery, 30.71% had caesarean section and 4.6% had instrumental delivery, 1.80% PPH, 0.45% puerperal sepsis and 2.16% wound sepsis. 97% neonates with APGAR score more than 7and 1.08% neonates were admitted to NICU. There were 0.27% fresh still births and 0.45% birth asphyxia.
Conclusions: Careful analysis of indication of induction of labor, selection of the patients, proper monitoring at the time of induction and strict partographic management of labor results in a healthy baby and mother.
Healthier mind builds healthier nation under ABArK
Authors: G. D. Gagana , Shastri Suresh G. , P. K. Srinivas , S. Pooja , J. Murugesh , Rajani Parthasarathy  , Devyani Azad , Rathore Himani , N. Shivashankara , D. Randeep 
Published: July 2023

Background: The State of Karnataka launched a scheme called “Arogya Karnataka” as a part of universal health coverage following the Karnataka Integrated Public Health Policy 2017 and Karnataka Vision 2025 document. With the goal of achieving universal health coverage (UHC), Karnataka, a national leader in healthcare, launched the Arogya Karnataka scheme in March 2018. It was later integrated with the government of India's national health protection scheme Ayushman Bharat Pradhan Mantri Jan Arogya Yojana(AB-PMJAY) to help with financial protection. Mental health, as defined by the World Health Organization (WHO), refers to “a state of well-being in which the individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to his or her community”.
Methods: A cross-sectional analysis of data collected from the State Health Agency, Suvarna Arogya Suraksha Trust (SAST) portal. The study was conducted for a period 12 months from January to December 2022.
Results: The study included 7292 mental disorder patients, majority of were male (70.95%), having age group of 31-45 years (45.41%), and belonged to the Below poverty line (BPL) (94.54%). Majority of cases were psychoactive substance use (64%) followed by Schizophrenia (22%) and Mental Retardation (14%).
Conclusions: Ayushman Bharat –PM-JAY Arogya Karnataka (AB-PMJAY ArK) has potential to reduce the out of pocket expenditure, distress financing and reduce catastrophic health expenditure which will lead to significant impact on health indices.
Co-creating sexual and reproductive health interventions with adolescents: the experience from Rajasthan
Authors: Mukherjee Ashish , Nair Amrutha , Ranjan Raghwesh 
Published: July 2023

Despite a clear policy recognition of the need for special programmatic attention for adolescents to ensure access to sexual and reproductive health information and services, almost all existing programs in India face critical challenges in effectively delivering sexual and reproductive health information and services, which leads to early marriages and teenage pregnancies. Teenage pregnancies directly threaten women's sexual and reproductive health and well-being. States like Rajasthan with high adolescent pregnancy rates demand better solutions. IPE Global implemented project Udaan to reduce teenage pregnancies in the state, adopting a 360 degree approach. Improving Sexual and Reproductive Health was one of the critical components of the project, and a human-centred design method was adopted to co-create an effective sexual and reproductive health intervention relevant to the community. The human-centred design approach incorporated multiple steps, including formative research, iterations, prototyping and piloting. Five potential interventions emerged after a series of iterative explorations. The in-school SRH intervention has emerged as an excellent model of reaching adolescents effectively in culturally sensitive rural geographies in the evaluation of the pilot, which successfully covered over 10,800 adolescent boys and girls across 66 government high schools in the Bari block of Dholpur. An independent evaluation suggested a significant increase in the awareness of contraceptive methods in the intervention area from 24 per cent to 50 per cent. Contraceptive self-efficacy, a measure of girls' agency, increased by 18 per cent in the intervention area. Further, qualitative findings showed a significant improvement in SRH awareness and service utilization.
AMBIENTES NO METAVERSO PARA FORMAÇÃO DOCENTE EM ARTES VISUAIS E TEATRO
Authors: Oliveira Régis Costa de , Silva Marineide Câmara 
Published: July 2023

O presente artigo descreve o processo de criação e customização de ambientes na plataforma de metaverso Spatial, desenvolvidos para os componentes curriculares Arte e Tecnologia, da Licenciatura em Artes Visuais do Instituto Federal de Educação, Ciência e Tecnologia do Maranhão (IFMA), Campus São Luís - Centro Histórico e História do Teatro III, da Licenciatura em Teatro da Universidade Federal do Maranhão (UFMA), Campus São Luís. A partir de referências teóricas de Roesller (2012), Ball (2021), Parreira, Lehman e Oliveira (2021), Backes e Schlemmer (2014) e Wakefield (2022), o artigo analisa as contribuições que as plataformas de metaverso podem trazer para a formação docente, com ênfase para os recursos presentes na plataforma Spatial, e a relação destes com as especificidades das licenciaturas em Artes Visuais e Teatro. Com base em experiências práticas, o artigo explora a criação de uma galeria virtual para a exposição coletiva Art and Tech, e sua utilização para as práticas da organização do espaço expositivo e da mediação cultural, bem como a construção de um arquivo virtual destinado ao registro das transformações do teatro Arthur Azevedo. As etapas percorridas durante a criação desses ambientes virtuais imersivos são analisadas, com destaque para as possibilidades de customização e adaptação pedagógica dos recursos tecnológicos oferecidos pela plataforma Spatial. Ao final, o artigo aponta para a importância de uma abordagem crítica em relação ao uso das tecnologias digitais na formação docente, bem como para a necessidade de um constante diálogo entre teoria e prática.
Impact of COVID-19 Pandemic on Breast Cancer Screening and Diagnosis Process
Authors: BÜLBÜL Hande Melike , HÜRSOY Nur , TAŞÇI Filiz , BEDİR Recep , BÜLBÜL Ogün , AYDIN Esra , PERGEL Ahmet 
Published: July 2023

Aim: The COVID-19 pandemic has caused delays in breast cancer screening and diagnostic procedures. The aim of this research was to compare the status of breast cancer screenings and newly diagnosed breast cancer cases during the pandemic compared to the pre-pandemic period.
Material and method: This retrospective study included patients with screening mammography, imaging-guided biopsies, and newly diagnosed breast cancer from March 2020– February 2021 (during-COVID-19) were compared with March 2019–February 2020 (pre-COVID-19). We compared numbers and distribution over time of mammography and biopsies between the time periods. In the breast cancer group; the stage at diagnosis and histopathological features of the tumor were also compared.
Results: Compared to pre-pandemic mammography scans, a 44% decrease was observed in total during pandemic, the most significant being in April (-98%) and May (-93%). While there was a significant decrease in the number of biopsies in April (-100%) and May (-69%), it was seen that there was no decrease in the pandemic period when the whole year was looked at with a rebound increase that started with 29% in June. In the breast cancer group, there was a significant increase in the number of patients who were metastatic at the time of diagnosis compared to the pre-pandemic period (p=0.001). No significant difference was observed between the two groups in terms of tumor grade, hormone receptor status, or HER2 positivity (p>0.05).
Conclusions: In this study, it was observed that both screening and diagnosis processes in breast cancer were significantly affected during the COVID-19 pandemic. It was observed that the delay in admission to the hospital in the first months of the pandemic resulted in an increase in patients who were metastatic at the time of diagnosis.
EVALUATION OF KM-4 CONCRETE PAVEMENT THICKNESS, LEMO VILLAGE ACROSS NORTH BARITO REGENCY
Authors: Fatimah Sonia , Yasruddin Yasruddin , Widayanti Nova 
Published: July 2023

Roads are transportation infrastructure used by the Indonesian people to carry out daily mobilization activities so that the volume of vehicles that pass through these roads affects their capacity and carrying capacity. Along with developments in North Barito Regency, one of which is the road in Lemo Village, it has become an alternative road to the road section of the capital city of Central Kalimantan Province, Palangka Raya.Planning for widening the Lemo Village road has the aim of determining the thickness of the rigid pavement which is guided by the Road Pavement Design Manual Number 02/M/BM/2017 and controlled using the Cement Concrete Road Pavement Planning guideline Pd T-14-2003 and then calculates the Budget Plan. on the widening of the Km 4 concrete pavement of Lemo Seberang Village.In planning the thickness of rigid pavement structures using the Road Pavement Design Manual Number 02/M/BM/2017, the concrete slab = 26.5 cm; LMC foundation layer = 10 cm; Drainage layer = 15 cm and using Cement Concrete Pavement Planning Guidelines Pd T-142003 obtained concrete slab = 25 cm; foundation layer = 10 cm. In addition, for data on field conditions in the form of a concrete slab = 25 cm; layer of concrete K-125 = 10 cm, then the efficient pavement thickness is taken, namely the Cement Concrete Pavement Planning Guidelines Pd T-14-2003 which is more efficient than field conditions. And also in writing this final project, it also discusses the Budget Plan for the widening of the KM 4 concrete pavement, Lemo Seberang Village, North Barito Regency. Keywords: Road Pavement Design Manual Number 02/M/BM/2017, Guidelines for Planning Cement Concrete Road Pavement Pd T-14-2003, Budget Plan
HUBUNGAN DUKUNGAN KELUARGA DENGAN KEPATUHAN KONSUMSI OBAT TABLET TAMBAH DARAH PADA REMAJA PUTRI DI SMAIT UKHUWAH BANJARMASIN
Authors: Prayudhistya Bagaskara Adji , Syahadatina Noor Meitria , Istiana Istiana , Juhairina Juhairina , Sterina Skripsiana Nika 
Published: July 2023

Remaja seringkali mengalami anemia defisiensi zat besi dengan alas an tingginya kebutuhan zat besi sehingga defisiensi besi di dalam tubuh cukup berat terjadi. Anemia defisiensi besi dapat dihindari dengan memenuhi zat besi melalui makanan yang bergizi serta mengonsumsi tablet tambah darah (TTD). Dukungan keluarga merupakan salah satu aspek keberhasilan pelaksanaan pemberian TTD. Tujuan penelitian ini adalah menjelaskan hubungan dukungan keluarga dengan kepatuhan konsumsi obat tablet tambah darah pada remaja puteri di SMAIT Ukhuwah Banjarmasin. Metode penelitian adalah observasional analitik dengan teknik purposive sampling dan jumlah sampel sebanyak 45 siswi remaja putri. Hasil penelitian menunjukkan dari 13 orang yang keluarganya tidak mendukung, mayoritas responden adalah tidak patuh sebanyak 9 orang (20%), hanya 3 orang (7%) yang patuh dalam konsumsi obat tablet tambah darah. Sedangkan dari 32 orang (71%) yang keluarganya mendukung, mayoritas responden adalah patuh mengonsumsi obat tablet tambah darah sebanyak 25 orang (55%) dan hanya 8 orang (18%) responden yang tidak patuh dalam konsumsi obat tablet tambah darah. Hubungan dukungan keluarga dan kepatuhan memiliki p value sebesar 0,000 dengan PR sebesar 3,09375. Hasil tersebut dapat disimpulkan bahwa terdapat korelasi signifikan (p value < 0,05) pada dukungan keluarga dengan kepatuhan konsumsi tablet tambah darah di SMAIT Ukhuwah Banjarmasin.
HUBUNGAN KEBIASAAN SARAPAN DAN ASUPAN ENERGI DENGAN KEJADIAN OBESITAS PADA MAHASISWA PSKPS FK ULM TAHUN 2022
Authors: Gina Amalia Reni , Juhairina Juhairina , Istiana Istiana , Budiarto Arief , Sterina Skripsiana Nika 
Published: July 2023

Obesitas adalah akumulasi lemak berlebih yang menimbulkan risiko bagi kesehatan. Berdasarkan Riskesdas 2018, kejadian obesitas di Indonesia (>18 tahun) sebesar 21,8% dengan kejadian obesitas (>18 tahun) di Kalimantan Selatan sebesar 19,5%. Obesitas disebabkan banyak faktor, diantaranya kebiasaan sarapan dan asupan energi. Penelitian ini bertujuan untuk menganalisis hubungan kebiasaan sarapan dan asupan energi dengan kejadian obesitas pada mahasiswa PSKPS FK ULM Tahun 2022. Penelitian ini menggunakan metode observasional analitik dengan pendekatan case control. Sampel penelitian adalah mahasiswa PKSPS FK ULM Angkatan 2019, 2020, 2021, dan 2022. Teknik pengambilan sampel menggunakan consecutive sampling dengan total sampel sebanyak 60 mahasiswa. Analisis data yang digunakan adalah analisis univariat, analisis bivariat menggunakan uji Chi-square serta analisis multivariat menggunakan uji regresi logistik. Hasil penelitian menunjukkan pada kelompok kasus mayoritas mahasiswa memiliki kebiasaan sarapan tidak teratur (86,6%) dan asupan energi berlebih (66,6%). Sementara itu, pada kelompok kontrol mayoritas mahasiswa memiliki kebiasaan sarapan teratur (90%) dan asupan energi seimbang (80%). Hasil analisis uji Chi-square menunjukkan terdapat hubungan antara kebiasaan sarapan (p=0,000) dan asupan energi (p=0,000) dengan kejadian obesitas pada mahasiswa PSKPS FK ULM Tahun 2022. Hasil analisis uji regresi logistik menunjukkan bahwa kebiasaan sarapan teratur (B=-4,071) dapat menurunkan kejadian obesitas 4 kali lipat melalui asupan energi seimbang.
STATUS GIZI PADA ANAK YANG MENDERITA DEMAM TIFOID
Authors: Nur ‘Ain Intan , Parlindungan Ringoringo Harapan , Hidayah Nurul , Panghiyangani Roselina , Rahmiati Rahmiati 
Published: July 2023

Bakteri Salmonella typhi menyebabkan demam tifoid, infeksi usus kecil yang parah. Usia, jenis kelamin, dan status gizi adalah tiga faktor yang sering diidentifikasi pada pasien demam tifoid yang masih anak-anak atau remaja. Pemeriksaan status gizi ini diambil menggunakan pengukuran antropometri. Riset ini bertujuan untuk menganalisis gambaran status gizi pada anak yang menderita demam tifoid di RSD Idaman Banjarbaru periode Oktober 2020-September 2022. Populasi riset ini sebanyak 51 pasien anak yaitu 25 balita dan 26 anak usia 5-18 tahun. Data yang digunakan ialah data sekunder dari RSD Idaman Banjarbaru. Hasil riset ini menunjukkan status gizi anak yang menderita demam tifoid berdasarkan usia mayoritas dialami pada usia 5-18 tahun sebanyak 26 anak (51%), berdasarkan jenis kelamin dialami oleh anak laki-laki sebanyak 32 anak (62.7%), berdasarkan BB/U pada balita dengan gizi buruk sebanyak 11 anak (44%), berdasarkan PB/U atau TB/U pada balita dengan gizi buruk sebanyak 15 balita (60%), berdasarkan BB/PB atau BB/TB pada balita dengan buruk sebanyak 8 balita (32%), dan berdasarkan IMT/U pada anak dengan gizi buruk sebanyak 18 anak (35.3%). Kesimpulan dari riset ini anak yang menderita demam tifoid memiliki status gizi baik.
HUBUNGAN LAMA STUDI TERHADAP TINGKAT PENGETAHUAN TENTANG PROGRAM PENGENDALIAN RESISTENSI ANTIBIOTIK PADA DOKTER MUDA DI RSUD ULIN BANJARMASIN
Authors: Agung Perdana Muhammad , Muthmainah Noor , Rahmiati Rahmiati , Biworo Agung , Wana Nur'amin Hendra 
Published: July 2023

Faktor paling banyak penyebab terjadinya resistensi antibiotik adalah tingkat pengetahuan yang rendah terhadap pemakaian dan peresepan suatu antibiotik, serta kurangnya pengalaman dari seorang dokter. Hal ini membuat WHO dan Pemerintah Indonesia membentuk suatu program yang bertujuan untuk mengawasi dan mengurangi kejadian dari resistensi antibiotik yaitu Program Pengendalian Resistensi Antibiotik. Penelitian ini bertujuan menganalisis hubungan lama studi terhadap tingkat pengetahuan tentang program pengendalian resistensi antibiotik pada dokter muda di RSUD Ulin Banjarmasin. Penelitian ini dilakukan dengan metode observasional analitik dengan pendekatan cross sectional pada 170 orang dokter muda di RSUD Ulin Banjarmasin. Teknik pengambilan sampel dilakukan dengan metode simple random sampling. Data diambil menggunakan kuesioner melalui google form, kemudian dianalisis menggunakan uji chi square. Hasil penelitian yang dilakukan pada 170 sampel yang terbagi menjadi 2 kategori berdasarkan lama studi kepaniteraan klinik yaitu baru bila < 1 tahun dan lama bila ³ 1 tahun menunjukkan bahwa terdapat 151 orang yang memiliki tingkat pengetahuan baik dan 19 orang memiliki tingkat pengetahuan kurang tentang program pengendalian resistensi antibiotik. Dari hasil uji statistik terdapat hubungan lama studi terhadap tingkat pengetahuan tentang program pengendalian resistensi antibiotik pada dokter muda di RSUD Ulin Banjarmasin (p£0,001).