bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Real Lubricant Density–Pressure Behavior on the Dynamic Response of Elastohydrodynamic Lubricated Conjunctions
Authors: Issa J. S. , Habchi W. 
Published: January 2023

Abstract
The current work investigates the influence of real lubricant density–pressure behavior on the dynamic response of elastohydrodynamic lubricated conjunctions. Such a response is often based on a nonrealistic universal equation of state, despite longstanding evidence of its lack of support by measurements. A finite element framework is employed to investigate the damping and stiffness characteristics of line contact elastohydrodynamic (EHD) lubricating films, subject to a harmonic loading. Both the equivalent stiffness and damping coefficients of lubricating films are found to increase with the base applied external load and its amplitude of oscillation. They decrease however with increasing mean entrainment speed and load oscillation frequency. That is, they both increase as lubricant films get thinner. By comparison with the real density–pressure response of a highly compressible silicon oil, the universal equation of state is shown to underestimate the lubricant film’s stiffness and damping characteristics. The relative deviations in equivalent damping and stiffness coefficients can reach up to about 12% and 25%, respectively. Therefore, realistic lubricant characteristics should always be considered. In particular, the use of the universal equation of state should not be taken for granted, as is customary in the elastohydrodynamic lubrication (EHL) literature. Lubricant density–pressure response is not of a secondary nature when it comes to predicting the dynamic performance characteristics of EHL conjunctions.
On the Lubrication and Stability Behaviors of a Conical Hybrid Floating Ring Bearing With Thermal Effects
Authors: Yang Shuai , Jiang Xueqing , Zhang Shaolin , Guo Hong , Cen Shaoqi 
Published: January 2023

Abstract
The conical bearing can withstand both journal and axial load because of the conical-shape fluid film, and an investigation concerning the thermodynamic lubrication and stability properties is proposed for a conical hydrostatic/hydrodynamic floating ring bearing theoretically and experimentally. The finite element method is coupled with the finite difference method to solve the variable-viscosity Reynolds equations, thermal energy equations, and the corresponding boundary conditions for the inner and outer films in a floating ring equilibrium state, and the conical bearing-rotor dynamic and stability performance models are built up with the perturbation theory and Routh–Hurwitz method. The primary characteristics parameters that are obtained under different operational conditions suggested that there presents a significant temperature gradient distribution over the lubricated domain, the thermal effects decrease the load carrying capacity, friction power loss, and stiffness and damping coefficients, and the viscous dissipation influences the variation of threshold instability speed with eccentricity and reduces its maximum value. In experiments, the temperature distributions of the oil leakage flow are measured to compare with the calculated results for the validation of the mathematic model using an infrared thermal imager, and the thermal effects need to be taken into consideration for the bearing lubrication analysis and design.
Magmatic record of changing Cordilleran plate-boundary conditions—Insights from Lu-Hf isotopes in the Mojave Desert
Authors: Howard Keith A. , Shaw Stirling E. , Allen Charlotte M. 
Published: January 2023

Abstract
Belts of Cordilleran arc plutons in the eastern part of the Mojave crustal province, inboard from the southwestern North American plate boundary, record major magmatic pulses at ca. 180–160 and 75 Ma and smaller pulses at ca. 100 and 20 Ma. This cyclic magmatism likely reflects evolving plate-margin processes. Zircon Lu-Hf isotopic characteristics and inherited zircons for different-age plutons may relate magma sources to evolving tectonics. Sources similar in age to the bulk of the exposed Mojave crust (1.6–1.8 Ga) dominated the magmas. Rare zircons having εHf(t) values as low as −52 indicate that Cretaceous melt sources also included more ancient crustal components, such as Archean-derived detritus in supracrustal gneisses of the Vishnu basin. Some rocks signal contributions from mantle lithosphere (in the Miocene) or asthenosphere (middle Cretaceous).
Temporal shifts in isotopic pattern in this sample of the Cordillera relate to cyclic pulses of magmatic flux. Hf-isotopic pull-downs suggestive of dominantly crustal sources characterize the Jurassic and Late Cretaceous flare-ups. The Late Cretaceous flare-up, occurring near the onset of flat-slab subduction, produced abundant Proterozoic xenocrystic zircon and Hf isotopes implicating derivation largely from heterogeneous deep Mojave crust. Isotopic pull-ups characterize the lower-flux middle Cretaceous and Miocene magmatic episodes. The middle Cretaceous pulse ca. 105–95 Ma produced Mojave crust signals but also the isotopically most juvenile magmatic zircons, ranging upward to barely positive εHf values and suspected to signal an asthenosphere contribution. This may point toward transtension or slab retreat causing 105–95 Ma backarc extension in the Mojave hinterland of the Cordillera. That possibility of backarc extension raises questions about the tectonic environment of the contemporaneous main Sierra Nevada high-flux arc closer to the continental margin.
Boudinage and the rheology of syntectonic migmatites in the high-strain Taili deformation zone, NE China
Authors: Li Zhiyong , Zeng Zuoxun , Liu Yongjiang 
Published: January 2023

Abstract
This paper presents a detailed field characterization of boudinage in a high-strain zone several kilometers wide in Northern China to establish relationships between boudin types and rheological contrasts between different parts of migmatites during the migmatization process. This zone contains nearly all types of boudins: foliation boudins, blocktorn boudins, pinch- and- swell structures, tapering boudins, object boudins, and modified boudins. These boudinage structures record the different stages of melt-involved and solid-state deformation.
The boudinage of migmatites is significantly controlled by the evolving rheological contrasts between the leucosome and melanosome. During the melting stage, the deformation and boudinage of rocks are controlled by the melt fraction. Migmatite strength progressively decreases with increasing melt fraction. The occurrence of melt-filled foliation boudins and melanosome block boudins suggests that the residuum and melanosome are more competent than the leucosome. During solid-state deformation after crystallization, the existence of recrystallized solid-state leucosomes and the intrusion of pegmatites cause the migmatite strength to increase. The relationship is reversed: the leucosome is much more competent than the melanosome. The type and geometry of boudins and pinch- and- swell structures are correlated to the fraction of leucosome in the migmatites. The mechanical strength and strain localization of migmatites after crystallization depend on the presence and volume fraction of the different mineral phases, as well as the mineral grain size. The type and geometry of boudins suggest that the effective viscosity of migmatite can be ranked, from high to low, as: quartz veins; coarse-grained, thick pegmatite; coarse-grained, diatexite migmatite; medium-grained leucosome; and fine-grained melanosome.
While experiencing partial melting and migmatization, a rheologically homogeneous protolith is turned into two dominant lithologic domains: a competent diatexite migmatite domain and an incompetent melanosome migmatite domain. Spatially, with the increasing leucosome fraction in migmatites, the migmatite rheology of rock changes from homogeneous to heterogeneous and anisotropic, and then back to homogeneous. The strain distribution likewise changes from uniform to partitioned, and then back to uniform. This evolutionary process of strength and rheological properties of rocks during migmatization may promote strain localization at mid-crustal conditions.
Public health guidelines for physical activity during pregnancy from around the world: a scoping review
Authors: Hayman Melanie , Brown Wendy J , Brinson Alison , Budzynski-Seymour Emily , Bruce Tracy , Evenson Kelly R 
Published: January 2023

Background and objectiveDespite the known health benefits of physical activity (PA), pregnancy is a time of marked decline in PA levels. To provide women with reliable and trustworthy information, and to encourage greater participation in PA during pregnancy, many governments have developed guidelines for PA during pregnancy. Our aim was to synthesise the most recent public health guidelines on PA during pregnancy from different countries in order to understand the nature and extent of advice that is available.DesignScoping review.Data sourcesSearch of the grey literature, direct contact with international experts, screening of relevant academic literature and citation searching.Eligibility criteriaPublic health guidelines developed or endorsed by government departments published since 2010.ResultsOur search located 30 eligible guidelines, published in 11 different languages. There is remarkable concordance in the advice offered. For women with uncomplicated pregnancy, guidelines recommend: 150–300 min/week of moderate intensity aerobic activity; pelvic floor and muscle strengthening exercises; modification of some exercises (eg, supine position); and provide lists of warning signs to cease activity (eg, persistent dizziness, vaginal bleeding) and activities that should be avoided (eg, if high risk of falling/collision). Few guidelines offer specific advice for highly active women (eg, athletes), or trimester-specific or culturally specific considerations.ConclusionsThis review provides a summary of public health recommendations for PA during pregnancy around the world. The challenge is now to ensure that all who provide healthcare for women understand the guidelines and encourage safe participation in PA during pregnancy.
Chondroblastoma: clinicopathological analyses of 307 cases from a single institution in China and the diagnostic value of the H3F3 K36M mutant antibody
Authors: Zhao Qianqian , Tang Juan , Luo Yanli , Huang Jin , Hu Dingjun , Zhu Jinyu , Jiang Ting , Zhang Huizhen , Liu Zhiyan 
Published: January 2023

AimsTo elucidate the clinicopathological features and the diagnostic value of mutation specific antibody H3F3 K36M of chondroblastoma (CB) in China.MethodsClinicopathological profiles were retrieved, and immunohistochemistry was performed on 185 CB specimens and the control group.ResultsOur series included 307 patients with a mean age of 22.1 years. Long tubular bones (63.8%, 196/307) were most commonly involved, followed by short bones of the hands and feet (22.1%, 68/307), sesamoid bones (8.1%, 25/307), flat bones and irregular bones (5.9%, 18/307). The most commonly involved site was the proximal femur, followed by distal femur, proximal humerus and calcaneus. The average age in the long bones group (20.3 years) was significantly younger than the short bones group (24.9 years) (p<0.001), sesamoid bones group (24.4 years) (p=0.02) and flat bones and irregular bones group (29.1 years) (p<0.001). Microscopically, aneurysmal bone cyst-like change (63.6%, 117/184), necrosis (43.5%, 80/184) and chicken-wire calcification (26.1%, 48/184) were variably noted. In rare cases, cortical destruction, soft tissue and lymphovascular invasion were identified. Positive immunoreaction with H3F3 K36M was examined in all non-decalcified, all EDTA decalcified, 87.1% hydrochloric acid (HCl) decalcified CB samples and the high-grade sarcoma secondary to CB, but not the control group.ConclusionsCB usually involves the long tubular bones in younger age group. H3F3 K36M can identify K36M mutation with 100% specificity and 100% sensitivity in non-decalcified and EDTA decalcified samples, more than 80% sensitivity in HCl decalcified samples. Virtually, all CBs harbour an H3K36M mutation.
Improving practice in PD-L1 testing of non-small cell lung cancer in the UK: current problems and potential solutions
Authors: Gosney John R , Peake Michael D , Kerr Keith M 
Published: January 2023

AimsProgrammed cell death ligand 1 (PD-L1) expression, used universally to predict response of non-small cell lung cancer (NSCLC) to immune-modulating drugs, is a fragile biomarker due to biological heterogeneity and challenges in interpretation. The aim of this study was to assess current PD-L1 testing practices in the UK, which may help to define strategies to improve its reliability and consistency.MethodsA questionnaire covering NSCLC PD-L1 testing practice was devised and members of the Association of Pulmonary Pathologists were invited to complete this online.ResultsOf 44 pathologists identified as involved in PD-L1 testing, 32 (73%) responded. There was good consistency in practice and approach, but there was wide variability in the distribution of PD-L1 scoring. Although the proportions of scores falling into the three groups (negative, low and high) defined by the 1% and 50% ‘cut-offs’ (38%, 33% and 27%, respectively) reflect the general experience, the range within each group was wide at 23–70%, 10–60% and 15–36%, respectively.ConclusionsThere is inconsistency in the crucial endpoint of PD-L1 testing of NSCLC, the expression score that guides management. Addressing this requires formal networking of individuals and laboratories to devise a strategy for its reduction.
Stand validation of lidar forest inventory modeling for a managed southern pine forest
Authors: Strunk Jacob L. , McGaughey Robert J. 
Published: January 2023

We evaluated area-based approaches (ABAs) to light detection and ranging (lidar) predictions of plot- and stand-level forest attributes (tree count, height, basal area, volume, aboveground biomass, broadleaf/conifer, and diameter at breast height — “diameter”). ABA methods included post-stratification (PS), ordinary least squares (OLSs) regression, k nearest neighbors ( kNN), and random forest (RF). This study was conducted on the Savannah River Site in South Carolina, USA. Plot- and stand-level predictions were validated against fixed-radius 0.04 ha (0.1 acre) plots in 49 ≈2.0 ha (5 acre) stands. Our findings demonstrate that lidar can be incorporated operationally into forest inventory systems to provide stand-level inferences for a wide range of forest attributes. Volume predictions for specific diameter classes, however, often fared poorly (root mean squared error (RMSE) > 100%) for the methods we explored, especially for larger (less common) diameter trees. Stand-level results were consistently better than pixel-level results (10–200+ percentage points). kNN and RF performed similarly and better than OLS and PS, but RF was the most robust to model configurations, while kNN has practical advantages such as simultaneous predictions of many attributes.
Evaluating community science sampling for microplastics in shore sediments of large river watersheds
Authors: Forrest Shaun A. , Alambo Katherine , Holman Larissa , Vermaire Jesse C. 
Published: January 2023

A community science project in the Ottawa River Watershed in Canada interacted with an existing volunteer base to collect sediment from 68 locations in the watershed over approximately 750 km. Ninety-one percent of the distributed kits were returned with 42 volunteers taking part in the project. After analysis, particle concentrations were relatively low compared to previous freshwater microplastic sediment research, with contributing factors including (but not limited to) the large size of the watershed, a lower population base compared to other researched freshwater watersheds, the relative size and discharge of the Ottawa River and the large seasonal fluxes experienced in the river basin. Utilising community science for sampling large freshwater watersheds demonstrated its advantages in the research, especially spatially. However, careful consideration to research design and implementation is essential for community science projects examining microplastics in freshwater sediments. Research teams should ensure they are responsible for strict quality assurance and quality control protocols, especially in the laboratory with sample preparation and processing. Nonetheless, community science is potentially an extremely useful approach for researchers to use for microplastic sampling projects over large spatial areas.
An Efficient COVID-19 Disease Outbreak Prediction Using BI-SSOA-TMLPNN and ARIMA
Authors: Sasikala P. , Sheela L. Mary Immaculate 
Published: January 2023

Globally, people’s health and wealth are affected by the outbreak of the corona virus. It is a virus, which infects from common fever to severe acute respiratory syndrome. It has the potency to transmit from one person to another. It is established that this virus spread is augmenting speedily devoid of any symptoms. Therefore, the prediction of this outbreak situation with mathematical modelling is highly significant along with necessary. To produce informed decisions along with to adopt pertinent control measures, a number of outbreak prediction methodologies for COVID-19 are being utilized by officials worldwide. An effectual COVID-19 outbreaks’ prediction by employing Squirrel Search Optimization Algorithm centric Tanh Multi-Layer Perceptron Neural Network (MLPNN) (SSOA-TMLPNN) along with Auto-Regressive Integrated Moving Average (ARIMA) methodologies is proposed here. Initially, from the openly accessible sources, the input time series COVID-19 data are amassed. Then, pre-processing is performed for better classification outcomes after collecting the data. Next, by utilizing Sine-centered Empirical Mode Decomposition (S-EMD) methodology, the data decomposition is executed. Subsequently, the data are input to the Brownian motion Intense (BI) - SSOA-TMLPNN classifier. In this, the diseased, recovered, and death cases in the country are classified. After that, regarding the time-series data, the corona-virus’s future outbreak is predicted by employing ARIMA. Afterwards, data visualization is conducted. Lastly, to evaluate the proposed model’s efficacy, its outcomes are analogized with certain prevailing methodologies. The obtained outcomes revealed that the proposed methodology surpassed the other existing methodologies.
The Ordovician of France and neighbouring areas of Belgium and Germany
Authors: Lefebvre Bertrand , Álvaro J. Javier , Casas Josep Maria , Ghienne Jean-François , Herbosch Alain , Loi Alfredo , Monceret Eric , Verniers Jacques , Vidal Muriel , Vizcaïno Daniel , Servais Thomas 
Published: January 2023

Abstract
The Ordovician successions of France and neighbouring areas of Belgium and Germany are reviewed and correlated based on international chronostratigraphic and regional biostratigraphic charts. The same three megasequences related to the rift, drift and docking of Avalonia with Baltica can be tracked in Belgium and neighbouring areas (Brabant Massif and Ardenne inliers), western (Rhenish Massif) and northeastern Germany (Rügen). The remaining investigated areas were part of Gondwana in the Ordovician. The Armorican Massif shares with the Iberian Peninsula a Furongian–Early Ordovician gap (Toledanian or Norman gap), and a continuous Mid–Late Ordovician shelf sedimentation. The Occitan Domain (Montagne Noire and Mouthoumet massifs), eastern Pyrenees and northwestern Corsica share with southwestern Sardinia continuous shelf sedimentation in the Early Ordovician, and a Mid Ordovician ‘Sardic gap’. In the Ordovician, the Maures Massif probably belonged to the same Sardo-Occitan domain. The Vosges and Schwarzwald massifs display comparable, poorly preserved Ordovician successions, suggesting affinities with the Teplá-Barrandian and/or Moldanubian zones of Central Europe.
Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time
Authors: Nguyen Tuyen Duong Thanh , Wang Yan , Bui Tuyen N. , Lazcano Rossana , Ingram Davis R. , Yi Min , Vakulabharanam Varshini , Luo Linjie , Pina Marc A. , Karakas Cansu , Li Mi , Kettner Nicole M. , Somaiah Neeta , Hougton Peter J. , Mawlawi Osama , Lazar Alexander J. , Hunt Kelly K. , Keyomarsi Khandan 
Published: January 2023

AbstractTreatment strategies with a strong scientific rationale based on specific biomarkers are needed to improve outcomes in patients with advanced sarcomas. Suppression of cell-cycle progression through reactivation of the tumor suppressor retinoblastoma (Rb) using CDK4/6 inhibitors is a potential avenue for novel targeted therapies in sarcomas that harbor intact Rb signaling. Here, we evaluated combination treatment strategies (sequential and concomitant) with the CDK4/6 inhibitor abemacicib to identify optimal combination strategies. Expression of Rb was examined in 1,043 sarcoma tumor specimens, and 50% were found to be Rb-positive. Using in vitro and in vivo models, an effective two-step sequential combination strategy was developed. Abemaciclib was used first to prime Rb-positive sarcoma cells to reversibly arrest in G1 phase. Upon drug removal, cells synchronously traversed to S phase, where a second treatment with S-phase targeted agents (gemcitabine or Wee1 kinase inhibitor) mediated a synergistic response by inducing DNA damage. The response to treatment could be noninvasively monitored using real-time positron emission tomography imaging and serum thymidine kinase activity. Collectively, these results show that a novel, sequential treatment strategy with a CDK4/6 inhibitor followed by a DNA-damaging agent was effective, resulting in synergistic tumor cell killing. This approach can be readily translated into a clinical trial with noninvasive functional imaging and serum biomarkers as indicators of response and cell cycling.Significance:An innovative sequential therapeutic strategy targeting Rb, followed by treatment with agents that perturb DNA synthesis pathways, results in synergistic killing of Rb-positive sarcomas that can be noninvasively monitored.