bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting access to comprehensive services: A scoping review of national policies related to autism in mainland China
Authors: Zou Mingyang , Han Yujiao , Jin Meiyu , Xie Wei , Shang Chuang , Li Tiantian , Feng Liwen , Sun Caihong , Zhang Saisai , Wu Lijie 
Published: January 2025

The study was designed to review autism-associated policies, describe policy characteristics, and determine potential policy gaps compared with the recommendations set by the World Health Organization. Autism-associated policies in 15 government agencies and public institutions were thoroughly searched on ministry websites up to December 2022, where 81 of 2504 were retained. And 42 of the 81 policies were issued in 2021 and 2022. Twelve of the 15 included ministries were involved in policymaking, yet fewer than one third of the policy documents were jointly issued by multiple ministries, which are crucial for the effective implementation of autism-associated policies. Compared with the World Health Organization recommendations (the Comprehensive Mental Health Action Plan 2013–2030 and the Six Building Blocks of Health System), several areas showed a strong policy commitment, including leadership and governance, service delivery, and access to medicines and facility. Several potential gaps remained, including a relative lack of emphasis on health information and the health workforce, and insufficient attention to the community. Despite these potential gaps, encouragingly, the nation has increasingly focused on autism groups. This study can provide a basis for future policymaking to provide more comprehensive and better services for individuals with autism. Lay abstract Policies have been found to play a crucial role in supporting the health and well-being of individuals with autism. Yet, relatively few policy reviews are related to autism, and the current level of autism-associated policies and potential gaps in comparison with the World Health Organization recommendations remain unclear. Our study reviewed autism-associated policies, described policy characteristics, and determined potential policy gaps in mainland China. We conducted a comprehensive search of autism-associated policies from 15 websites of government agencies and public institutions up to December 2022, where 81 of 2504 were retained. We found that 42 of the 81 policies were issued in 2021 and 2022. Twelve of the 15 included ministries were involved in policymaking and fewer than one third of the policy documents were issued by two or more ministries. With respect to recommendations proposed by the World Health Organization (the Comprehensive Mental Health Action Plan 2013–2030 and the Six Building Blocks of Health System), several areas received extensive national attention, including leadership and governance, service delivery, and access to medicines and facility, while there was limited policy attention on the other components. Despite these potential gaps, encouragingly, the nation has increasingly focused on autism groups. This study can provide a basis for future policymaking to provide more comprehensive and better services for individuals with autism.
Comprehension and production of (non-)reflexive possessive constructions in Abui by Alor Malay–Abui bilingual children
Authors: Shin Gyu-Ho , Saad George , Kratochvíl František 
Published: January 2025

Aims and objectives/purpose/research questions: We investigate how Alor Malay–Abui child bilinguals, a non-WEIRD and underrepresented population in the field, comprehend and produce reflexive and non-reflexive possessive constructions in Abui. Their profiles of language development are explored through functionalist accounts that highlight the close connection between language and domain-general learning capacities, with special emphasis on three models: Competition Model, usage-based approach, and processing determinism. Design/methodology/approach: A total of 17 children (experimental group) and 17 adults (comparison group) complete a forced-choice sentence comprehension task (where they listen to two sentences following a short video prompt and verbally select the sentence that best describes the clip) and an elicited production task (where they watch a series of video clips and describe what is happening in each clip in a semi-spontaneous way). Data and analysis: This study employs mixed-effects modelling for data analysis. The global model per experiment includes Condition (reflexive; non-reflexive) and Group (child; adult) as fixed effects and Participant and Item as random effects, with the maximal random-effects structure allowed by the model. Findings/conclusions: Results show asymmetric performance by bilingual children on the two construction types across both experiments. Our findings provide insight into the developing processor in bilingual children, influenced by various factors such as usage frequency, cognitive skills, and task effects, within the functionalist framework. Originality and significance/implications: The findings of this study align with functionalist accounts for language development, illuminating the intricate deployment of linguistic knowledge in the minds of bilingual children interfacing with language-usage experience and domain-general factors. By combining the three models of functionalism, our findings are more properly understood, highlighting their complementary nature in addressing developmental trajectories of linguistic knowledge for child bilinguals. Importantly, our study shifts our attention to a unique bilingual context that has not been explored – lesser-studied languages and learning environments, contributing to offsetting the sampling bias persistent in the field.
Verbal Memory is Higher After Aerobic Exercise When Compared to Muscle Stretching
Authors: Doku Abigail , Roupe Gavin T. , Rankine Emma , Flemming Isabel , Provost Jacob A. , Zuhl Micah , Otani Hajime 
Published: January 2025

Acute exercise is linked to memory improvement. Several mediators may influence the effect of exercise such as the type of exercise (aerobic exercise, muscle stretching). Purpose: The primary aim was to analyze memory outcomes after a 20-min bout of aerobic exercise or muscle stretching. Methods: 42 healthy participants ages 18-35 were randomized to perform 20 min of either moderate-intensity aerobic exercise (AE) on a treadmill or muscle stretching exercise (SE). After exercise, memory was assessed using the Rey Auditory Verbal Learning Test (RAVLT). The relationship between exercise heart rate and memory outcomes were evaluated within each group. Results: Immediate learning as well as delayed recall was higher after AE compared to SE. Heart rate during exercise correlated with immediate learning in the AE group only. Conclusion: Acute exercise that elicits a heart rate response may be important for improving memory.
Navigating Inclusive Research in PhD Studies: A Model for Limited Resource Environments
Authors: Ryan Laura , Ellem Kathy , Le Brocque Robyne , Mitchell Claire , Langdon Luka 
Published: January 2025

Inclusive research, which emphasises the active involvement of people with disabilities in the research process, is increasingly recognised as vital for enhancing research quality. Despite its importance, there is a significant gap in the literature regarding implementing inclusive research within doctoral studies in health and wellbeing. This paper has addressed this gap by providing a practical model of how the first author conducted PhD research with two health service consumer advisors with Down syndrome. The consumer advisors participated in eleven meetings lasting up to 2 hours, with a tailored involvement plan that considered their specific needs. The paper has drawn on reflections and feedback from both the PhD student and the advisors, using sources from reflective journals, email exchanges, and meeting notes. The consumer advisors remained engaged throughout the project, offering valuable insights relating to the design, data collection, interpretation and dissemination of the findings. The study highlighted that inclusion can be adapted to fit specific circumstances, even within the constraints of higher degree research and limited resources. It has underscored the importance of consumer advisor involvement for the success of doctoral research. The paper concludes by stressing the need for universities to support PhD students in fostering inclusive research practices.
An Exploration of Serious Falls After Stroke Using a Large International Stroke Rehabilitation Database
Authors: Wang Julian , Bernhardt Julie , Johns Hannah , Churilov Leonid , Said Catherine M , Fini Natalie Ann , Batchelor Frances , Collier Janice , Ellery Fiona , Bower Kelly 
Published: January 2025

Background: Falls are common after stroke and can have serious consequences such as hip fracture. Prior research shows around half of individuals will fall within the 12 months post stroke and these falls are more likely to cause serious injury compared to people without stroke. However, there is limited research on risk factors collected in the immediate post-stroke period that may relate to falls risk. Furthermore, the circumstances and consequences surrounding falls resulting in serious adverse events (serious falls) is underexplored. Aims: Using longitudinal cohort data from A Very Early Rehabilitation Trial (AVERT), we aimed to describe the occurrence, consequences, and circumstances of serious falls over 12 months post stroke and examine potential risk factors associated with these serious falls. Methods: Data from participants included in the AVERT trial (n = 2104; recruited from 56 stroke units across five countries) were analysed. Serious falls were defined as those resulting in death, were life threatening, or required/prolonged hospitalisation. Baseline variables included: demographics, pre-morbid function, stroke severity, hemi-neglect, functional independence and mobility. Statistical analysis included Wilcoxon-Mann-Whitney tests, Fisher’s tests, and Firth’s logistic regressions (adjusting for age, stroke severity and AVERT intervention group). Results: Of the 2104 participants, 85 (4%) experienced at least one serious fall (mean age 78.1 years, 45 male), with 91 individual falls. Fifty-five (60%) serious falls resulted in fracture, with 23 (42%) being hip fractures. Two (2%) falls resulted in death. Serious falls were most common during the day (26 of 38 reported), at home (30 of 63 reported) and while ambulating (22 of 42 reported). More serious falls were experienced by participants who were older, had worse premorbid mobility, were unable to walk 10m independently in the first 24 hours post-stroke, or required longer than 14 days to walk 50m unassisted. Conclusions: This large international prospective study found 1 in 25 stroke survivors experienced serious falls in the first year after stroke. Fractures were a common outcome of these falls, but the true post-stroke fracture rate is likely to be underestimated due to our study methods, such as the exclusion of individuals with poor premorbid mobility and the absence of data on fractures not relating to falls or leading to an inpatient hospital admission. Clear associations between older age, impaired pre- and early post-stroke mobility and heightened risk of serious falls were found. Integrating these factors into post-stroke screening tools could improve identification of individuals at greater risk of serious falls and lead to more focused rehabilitation and injury prevention.
Stress shielding in reverse shoulder arthroplasty using a proximally coated stem for proximal humeral fractures: Does it have clinical relevance?
Authors: Goñalons-Giol Francesc , Ventura-Parellada Cristina , Alonso-Rodríguez-Piedra Javier , Llorens-Martínez Xavier , Gàmez-Baños Ferran , Mora-Guix José-María 
Published: January 2025

Objectives To evaluate the clinical significance of stress shielding in patients who have undergone an uncemented reverse shoulder arthroplasty (RSA) with a proximally coated stem for complex proximal humeral fractures (PHF) comprising 3 or 4 parts, assessed at 2 years postoperatively. Additionally, this study aims to examine the correlation between tuberosity healing and clinical outcomes. Methods Setting: Single Centre. Patient Selection Criteria: 43 patients underwent surgery involving a cementless RSA with an anatomical stem (Mini Stem of Zimmer Biomet ® Comprehensive System) following an acute 3- or 4-part or 4-part with luxation PHF within 4 weeks of injury. Patients who were excluded from the study included those who passed away, did not have a minimum 2-year follow-up, or had undergone cemented RSAs or alternative humeral components, as well as those who required RSA due to fracture sequelae. Outcome Measures and Comparisons: Stress shielding, tuberosity healing and its positioning were evaluated. Clinical-functional assessments were made using the Constant and ASES scores. Furthermore, quality of life assessments, including QuickDASH score, SF-12, satisfaction test (SANE) and Visual Analogue Scale (VAS) were performed. Results Of the total shoulders, 6 (13.9%) were excluded, leaving 37 PHFs that met the inclusion criteria. The mean age at the time of surgery was 72 years (range, 61–85). Stress shielding was observed in 31 shoulders (83.8%). There was no observed correlation between stress shielding and clinical-functional or quality of life assessments. The greater tuberosity in patients without stress shielding was found to be above the tray (66.7%) ( P < 0.05). Tuberosity healing was observed in 94.6% (35/37) of the shoulders. Conclusions No significant clinical difference was observed between patients with and without stress shielding in terms of short-term functional outcomes. Successful consolidation of the tuberosities can be attained even in cases with notable stress shielding. Level of Evidence Level IV; Case Series; Treatment study.
Prognostic impact of depth of response and early tumour shrinkage in patients with BRAFV600E-mutated metastatic colorectal cancer treated with targeted therapy
Authors: Vetere Guglielmo , Germani Marco Maria , Antoniotti Carlotta , Salvatore Lisa , Pietrantonio Filippo , Lonardi Sara , Bensi Maria , Ghelardi Filippo , Calegari Maria Alessandra , Intini Rossana , Minelli Alessandro , Sullo Francesco Giulio , Boccaccio Chiara , Taravella Ada , Puccini Alberto , Lavacchi Daniele , Noto Laura , Salati Massimiliano , Scartozzi Mario , Cremolini Chiara 
Published: January 2025

Background: Encorafenib plus cetuximab (EC) is the standard of care for pre-treated BRAF V600E mutated metastatic colorectal cancer (mCRC). Depth of response (DpR) and early tumour shrinkage (ETS) previously showed a strong correlation with survival outcomes of first-line chemotherapy ± biological agents. Objectives: We aimed to assess potential predictors of primary resistance to EC ± binimetinib (B) and relationships of DpR/ETS with survival outcomes and clinical characteristics. Design: This is a retrospective real-world cohort study of BRAF V600E mutated mCRC patients treated with second-line EC ± B at 20 Italian centres. Methods: Measurable disease according to Response Evaluation Criteria In Solid Tumour (RECIST) 1.1 at baseline and at least one subsequent computed tomography (CT) scan were mandatory for inclusion. Clinical features associated with primary resistance, DpR and ETS were investigated. Relationships of DpR and ETS, both as binary, according to conventional (30% for DpR and 20% for ETS) and median cut-off values, and continuous variables, with progression-free (PFS), overall survival (OS) and duration of response (DoR) were assessed in non-primary resistant patients. Results: A total of 105 patients were included. The primary resistance rate was 28% (29/105) and was associated with baseline peritoneal metastases ( p = 0.04). Disease control and overall response rates were 72% (76/105) and 24% (25/105), respectively, with a median DpR of 15% and an ETS rate of 37% (28/76). Mucinous histology was associated with a significantly lower magnitude of DpR ( p = 0.005) and a lower rate of ETS ( p = 0.002). In the multivariable models, DpR significantly correlated with longer PFS as a dichotomous variable, according both to conventional (hazard ratio (HR)DpR ⩾30%: 0.52, 95% CI: 0.30–0.90, p = 0.02) and median cut-off values (HRDpR⩾15%: 0.55, 95% CI: 0.33–0.92, p = 0.03), and as a continuous variable (HR per 10% increment: 0.88, 95% CI: 0.78–0.98, p = 0.02), while correlations with OS were not confirmed. DpR was also significantly associated with longer DoR ( pDpR⩾30% = 0.04; pDpR⩾15% = 0.04; pcont. = 0.02), whereas no relationships of ETS with PFS, OS or DoR were detected. Conclusion: A DpR of at least 15% independently predicts PFS benefit in BRAF V600E mutated mCRC patients treated with second-line EC ± B.
Early Experience With the Quantum Total Ankle Prosthesis
Authors: Christie Lauren M. , Philbin Terrence M. 
Published: January 2025

The Quantum total ankle prosthesis is a newer Food and Drug Administration (FDA)-approved fourth-generation 2-component, fixed-bearing implant in its first-generation design. The purpose of this study was to evaluate early outcome data and present our initial experience with the Quantum implant with a minimum of a 1-year follow-up. A retrospective, single-centered chart and radiographic review was performed on all patients who underwent total ankle arthroplasty with the Quantum implant from December 2021 to August 2023. Implant survivorship, radiographic outcomes, clinical outcomes, and complications were evaluated. The survivorship for the implant was 100% for the tibial component and 91.67% for the talar component, respectively. Pre-operatively, there were 3 ankles with a coronal deformity greater than 10 degrees. Post-operatively, coronal plane deformity was 100% corrected into neutral alignment. This study is the first to report on short-term outcomes for the Quantum total ankle prosthesis. Our findings showed promising results of short-term implant survivorship with good clinical and radiographic outcomes. Level of Evidence: IV
Occupational health professionals’ and HR specialists’ perceptions of telemental health services in occupational health care settings: A qualitative study
Authors: Kervinen Elina , Vähätalo Lauri , Siukola Anna , Reho Tiia , Winell Klas , Sauni Riitta 
Published: January 2025

Objective The rise in mental health-related work disability pensions highlights the need for more research on how occupational health care (OHC) can support mental health, including the use of telehealth (TH) services in mental health care. Methods The research, employing a descriptive qualitative approach through interviews ( n = 42), focused on experiences of professionals from a private OHC service provider in Finland and human resource representatives (HRRs) of OHC client companies. Inductive content analysis was used to analyze the data. Results Our research suggests that TH services provided by OHC can enhance access to care and expedite the initiation of work ability support, particularly in mental health cases. However, potential challenges include a perceived sense of distance, superficiality in interactions, and difficulty in forming a comprehensive understanding due to few non-verbal cues. Conclusion A combined approach of TH and face-to-face services is suggested to provide flexible, and individualized support. Further studies on remote low-threshold discussion mental health services and studies comparing TH and face-to-face services are advised.
The benefits and safety of a virtual reality intervention in patients suffering from acute and chronic pain: A pilot study
Authors: Ma Bingjie , Zhang Libo , Ji Yun , Huang Xuehua , Yao Luandi , Cheng Wei , Hu Li , Lu Xuejing , Ma Ke 
Published: January 2025

Background To overcome the challenge of psychotherapist scarcity in applying pain psychotherapy in clinical practice, we developed a virtual reality (VR) program delivering weeks of pain psychotherapy without psychotherapists, with a focus on minimizing the risk of motion sickness. Objectives We conducted a single-arm pilot study to assess the efficacy and motion sickness associated with a VR session delivering guided imagery and breathing techniques selected from the initial course of our VR program, involving patients suffering from various acute and chronic pain. Methods Patients underwent a 15-min VR session. Pain-related and anxiety ratings using a 0–10 numerical rating scale were collected pre-, during-, post-VR and in 6-h follow-up. Motion sickness symptoms were assessed using Simulator Sickness Questionnaire pre- and post-VR. Results Patients ( n = 73) reported their perceived pain intensity and anxiety reduced significantly from pre- to post-VR by 22.9% and 45.0% (all p < 0.0001), respectively. Such modulatory effects of VR in pain perception and anxiety persisted at 30 min, 1 h, 2 h, and 6 h post-VR (all p < 0.0001). The pre-post beneficial effects of VR were independent from patients’ demographic characteristics and their pain duration. Importantly, only six patients (8.2%) had post-VR motion sickness symptoms, and only one patient reported moderate level of severity. Conclusion These findings suggest the selected VR session delivering pain psychotherapeutic techniques may be effective and tolerable for patients with varying pain conditions, which provides initial evidence for the development of future randomized controlled trials of the complete VR program.
Engaging and supporting young adults in smoking cessation: Insights from a mobile-based cessation program in China
Authors: Weng Xue , Yang Hongcui , Song Chuyu , Tu Jiayu , Liu Kefeng , Wang Man Ping 
Published: January 2025

Objective Evidence-based smoking cessation treatments are underutilized by young adult smokers. This study explored young smokers’ experiences with a mobile-based smoking cessation program that included a Quit & Win contest at a university in Zhuhai, China, aiming to identify key engagement and cessation mechanisms. Methods Twenty participants (aged 18–25 years) were selected through purposive sampling. Semistructured interviews explored participants’ experiences, motivations, and perceptions of the intervention. Thematic analysis was used to identify major themes from interview transcripts. Findings Two main themes emerged: (1) strategies for enhancing program engagement, including the influence of campus-wide smoke-free environments, the appeal of the Quit & Win contest, and the use of peer counselors for recruitment; and (2) strategies for supporting smoking cessation, emphasizing the importance of a multifaceted approach. This approach included financial incentives as a motivator for quitting, sustaining cessation efforts with online group support, and building a therapeutic alliance with cessation counselors. Conclusion Mobile-based interventions, combined with peer support, financial incentives, and campus-wide smoke-free activities, can effectively engage young adults in smoking cessation. Future interventions should implement comprehensive programs that incorporate these elements to address the unique challenges faced by this population.