bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glomerular filtration rate dynamics in patients with diffuse large B-cell lymphoma during induction immunopolychemotherapy
Authors: Nozdricheva A. S. , Lysenko I. B. , Guskova N. K. , Konovalchik M. A. , Maslov A. A. , Shalashnaya E. V. 
Published: September 2023

Aim. To study the glomerular filtration rate (GFR) dynamics during induction immunopolychemotherapy (PCT) in patients with newly diagnosed diffuse large B-cell lymphoma. Materials and methods. The study included 39 patients with newly diagnosed diffuse large b-cell lymphoma who received specialized treatment in oncohematology department of national medical research centre for oncology (Rostov-on-Don). Patients underwent induction pct according to the R-CHOP (rituximab, doxorubicin, cyclophosphamide, vincristine, prednisolone) regimen with accompanying therapy (allopurinol). blood sampling was carried out at 0, 24, 48, 72, 120 hours and 21 days of the 1st PCT cycle. GFR was calculated using the SKD-epicre formula (chronic Kidney disease epidemiology collaboration creatinine-based). statistical data processing was carried out using the IBM SPSS statistics 23 program. Results. According to the gfr level before the start of chemotherapy (0 hours), the patients were divided into two groups: group a with GFR > 90 ml / min / 1.73 m2 and group b with GFR < 90 ml / min / 1.73 m2. In group a, there were no significant dynamic changes in the GFR level during PCT. Group B patients reacted more acutely to the administration of pct, which was manifested in an even greater decrease in the gfr level at 48 hours of PCT, and at 120 hours of PCT, the GFR approached the optimal values. on the 21st day from the start of the 1st pct course, the studied indicator returned to its initial values at 0 hour. further, the patients of these groups were divided into subgroups depending on the disease stage: group a consisted of 12 people with stages I–II and 15 people with stages III–IV. In group B, there were an equal number of patients with stages I–II and III–IV – 6 people. In group a, in patients with stages I–II and III–IV before the start of PCT (0 hours) and during PCT, there were no differences in the GFR level dynamics. In group B, patients with stages I-II and III–IV had similar GFR before the start of PCT, and during treatment, they reflected the previously noted general group trend in GFR level dynamics. Conclusion. The study found that in patients with initially low GFR level, a further, even more pronounced decrease in GFR during pct is observed. at the same time, the absence of significant differences in GFR level depending on disease stage allows us to conclude that the leading role is not so much the stage of the disease and tumor volume, but rather the initial functional status of the kidneys in the development of renal dysfunction in patients with diffuse large B-cell lymphoma during R-CHOP therapy.
Oncologic effectiveness of open partial vertical laryngectomy in the treatment of early glottic cancer
Authors: Karpenko A. V. , Sibgatullin R. R. , Boyko A. A. , Nikolayeva O. M. 
Published: September 2023

Introduction. In the last decades, a discernable trend towards more frequent use of endoscopic laser surgery in operative treatment of cancer of the middle part of the larynx is observed. Smaller operative trauma, absence of tracheostomy, short hospitalization time, and better functional outcomes without compromising oncological outcomes are significant reasons for transition to endoscopic methods. However, local recurrence involving anterior commissure develops in every 4th patient. This can explain attempts to return to analysis of possibilities of a surgical alternative – open laryngectomies.Aim. To retrospectively analyze the oncologic effectiveness of open partial vertical laryngectomy in the treatment of early glottic cancer.Materials and methods. Results of treatment of 66 patients aged between 39 and 72 years (mean age 61.4 ± 8.7 years) with cT1–2N0m0 glottic cancer were analyzed. 33 patients had T1 tumors and 33 – T2. Anterior commissure was involved in 14 cases. Surgery was the only mode of treatment in 92.4 % of cases. Oncologic effectiveness was assessed with the following parameters: the rate of local, regional recurrence and kaplan–meyer overall survival.Results. mean follow up was 58.64 ± 28.33 months (range 8–120 months). The rate of local recurrence for the whole cohort, T1 and T2 cases was 4.5; 3.0 and 6.1 %. The difference in local recurrence rate between T1 and T2 cases was statistically insignificant. The anterior commissure involvement did not affect negatively the rate of local recurrence. Regional recurrence was detected in 3 (4.5 %) patients. Larynx was preserved in 63 patients (92.4 %). 5 year overall survival was 86.12 %.Conclusion. Open partial vertical laryngectomy is characterized by low rate of local recurrence and acceptable functional results. The method may be the optimal choice of treatment for certain subgroup of patients with more advanced and invasive tumors.
Prospects of epigenetic therapy of head and neck squamous cell carcinoma
Authors: Mustafin R. N. 
Published: September 2023

Introduction. Head and neck squamous cell carcinoma is the 6th most common malignant tumor. It is characterized by immune response evasion and drug resistance. To stimulate antitumor immune response, antibodies against such cell cycle checkpoints as programmed cell death 1 (pD-1) and programmed death-ligand 1 (pD-L1) are used. However, effectiveness of monotherapy with these checkpoint inhibitors turned out to be low, and combinations with other antitumor drugs have high risk of adverse events.Aim. To determine the most practical ways to influence epigenetic factors in treatment of head and neck squamous cell carcinoma.Materials and methods. Scientific literature published between 2011 and 2022 and indexed in the eLIBRARY, Scopus, woS, NCBI databases (398 articles, of which 76 were used) was analyzed.Results. prospects of development of epigenetic stimulation of expression of retroelements located in tumor genomes through inhibition of DNA methyltransferases, deacetylases and histone methyltransferases were considered. when retroelements are activated, their transcripts form double-stranded RNA stimulating T killers and interferon response (virus mimicry). for DNA methyltransferase inhibitors, restoration of tumor suppressor genes which are hypermethylated in squamous cell carcinoma is also observed. However, retroelement activation is a driver mechanism of carcinogenesis, and their nonspecific expression can lead to tumor progression and formation of secondary tumors. Therefore, in the virus mimicry method it is practical to use as targets microRNA complementary to retroelements which recruit epigenetic factors to their loci (RNA-directed DNA methylation), as well as antisense oligonucleotides against oncogenic microRNA associated with retroelements. These approaches allow to inhibit retroelements participating in carcinogenesis. Nonspecific method of retrotransposon activity suppression is being developed in antitumor therapy, but data show successful application of only reverse transcriptase inhibitors preventing insertions and progression of genomic instability. we have performed analysis of scientific literature on transposable elements-derived microRNA associated with head and neck squamous cell carcinoma. As a result, 31 microRNAs were identified, derived from: LINE: miR-1249, -151a, -211, -2355, -28, -31, -3144, -374a, -374b, -421, -450b, -511, -576, -577, -582, -708, -769, -887, -95; HERv: miR-1269a, -1911, -3200, -495; non-autonomous SINE: miR-335, -342, -378a, -3934, -487b; DNA transposons: miR-224, -584, -652. These microRNAs can serve as the basis for epigenetic therapy of head and neck squamous cell carcinoma.
Pembrolizumab in treatment of head and neck squamous cell carcinoma: clinical cases and real-world practice
Authors: Alymov Yu. V. , Romanov I. S. , Ignatova A. V. 
Published: September 2023

Recurrent and metastatic head and neck squamous cell carcinoma is a hard-to-treat pathology. median overall survival for standard chemotherapy regimens does not exceed 11 months. One of the factors decreasing treatment effectivenessis frequency of severe adverse events which are observed in every 2nd patient during standard therapy regimens. moreover, even if notable tumor regression is achieved, this effect is transient. Development of immunotherapy drugs, namely pembrolizumab, helps solve these problems. Clinical trials and real-world use of the drug show that in the 1st and 2nd therapy lines for recurrent and metastatic head and neck squamous cell carcinoma, pembrolizumab allows to achieve persistent treatment response, increase overall survival, and decrease the frequency of adverse events.
Reactive astrocytes and glioblastoma: are there new targets for more effective antitumor therapy?
Authors: Tyagunova E. E. , Dobrokhotova V. Z. , Dushina A. O. 
Published: September 2023

Introduction. Astrocytes in the brain of a healthy person perform a number of protective functions, contribute to maintaining the functional activity of neurons and their synapses. However, in some pathological conditions, they change their phenotype to a reactive one and can both remodel damaged areas and contribute to increased aggression and invasiveness of gliomas.Aim. To comprehensively study the features of reactive astrocytes and the chemo- and radioresistance of gliomas associated with reactive astrocytes.Materials and methods. The authors analyzed articles from the databases Elsevier, pubmed, Scopus, google Scholar, Embase, web of Science, The Cochrane Library, global Health, CyberLeninka and RSCI. when selecting articles, the indexing systems of journals and the citation of articles, the scientific novelty of research, the statistical significance of the results obtained in them were taken into account, publications with duplication of the results of previous studies were excluded. In the course of the study, data on the mutual influence of reactive astrocytes and glioma cells were systematized.Results. Astrocytes of the brain of healthy people are highly variable and heterogeneous, which further complicates the interpretation of published studies. At the same time, reactive astrocytes contribute to an increase in the chemoresistance and radioresistance of gliomas of different degrees of malignancy. At the same time, the exact mechanisms for controlling the interaction between reactive astrocytes and glioma cells, which contributed to less progression and invasion of the tumor or its regression, have not yet been established. However, this direction is now actively developing and is promising due to the possibility of additional effects on gliomas.Conclusion. At the moment, there is no effective treatment that can cope with gliomas, all existing treatment methods are aimed only at increasing the life expectancy of patients with gliomas. The results of recent studies suggest that, probably, the current insufficient effectiveness of chemo- and radiotherapy may be associated with a very close relationship between tumor cells and tumor-associated reactive astrocytes due to their mutual supportive effect. Therefore, the solution to the problem of incurable patients with gliomas may lie in a complex effect on both tumor cells and their microenvironment.
Spontaneous necrosis of parathyroid adenoma: clinical observation
Authors: Ilyin A. A. , Polkin V. V. , Isaev P. A. , Severskaya N. V. , Zhelonkina N. V. , Plugar A. K. , Ivanov S. A. , Kaprin A. D. 
Published: September 2023

Fine needle aspiration biopsy is a routinely used technique to determine the nature of thyroid and parathyroid nodules. The complications and side effects associated with this procedure are minimal. At the same time, the histological alterations resulting from its use are well documented. Their range is quite w, however, from a clinical point of view, the most striking and catastrophic in their consequences are extensive heart attacks and necrosis. Such changes more often than in formations of a different morphological nature occur in tumors from oxyphilic cells. It should be noted that a lot of works devoted to post-biopsy changes are naturally focused on the morphological aspects of this problem, or are presented in the form of a presentation of individual clinical observations.This report presents the observation of necrosis in the parathyroid adenoma, which developed before fine needle aspiration biopsy.
Capabilities of delayed microsurgical reconstruction in patients with squamous cell carcinoma of the buccal mucosa: clinical case
Authors: Guz A. O. , Garev A. V. , Fatkullin D. M. , Zaharov A. S. , Sokolova M. I. 
Published: September 2023

Surgical treatment of patients with locally advanced squamous cell carcinoma of the oral mucosa is a complicated problem requiring maximal surgical radicality and, at the same time, single-stage reconstruction to preserve organ function and achieve acceptable esthetic results. One of modern reconstruction techniques is the use of free flaps. Application of this technique requires microsurgical skills from the surgeon. unfortunately, it is not always possible to achieve the result after single-stage postoperative defect closure. Sometimes unforeseen complications are observed: necrosis of the moved flaps, formation of large postoperative defects, orostomas, pharyngostomas. In such cases, oncologists face a more complicated problem: defect reconstruction in the conditions of pronounced scarring process in the intervention area, development of post-radiation fibrosis and soft tissue edema.The presented clinical case demonstrates the capabilities of repeat microsurgical reconstruction in patients with orostoma developed after unsuccessful primary reconstruction.
Evaluating the Accuracy of scite, a Smart Citation Index
Authors: Bakker Caitlin , Theis-Mahon Nicole , Brown Sarah Jane 
Published: September 2023

Objectives: Citations do not always equate endorsement, therefore it is important to understand the context of a citation. Researchers may heavily rely on a paper they cite, they may refute it entirely, or they may mention it only in passing, so an accurate classification of a citation is valuable for researchers and users. While AI solutions have emerged to provide a more nuanced meaning, the accuracy of these tools has yet to be determined. This project seeks to assess the accuracy of scite in assessing the meaning of citations in a sample of publications.
Methods: Using a previously established sample of systematic reviews that cited retracted publications, we conducted known item searching in scite, a tool that uses machine learning to categorize the meaning of citations. scite's interpretation of the citation's meaning was recorded, as was our assessment of the citation’s meaning. Citations were classified as mentioning, supporting or contrasting. Recall, precision, and f-measure were calculated to describe the accuracy of scite's assessment in comparison to human assessment.
Results: From the original sample of 324 citations, 98 citations were classified in scite. Of these, scite found that 2 were supporting and 96 were mentioning, while we determined that 42 were supporting, 39 were mentioning, and 17 were contrasting. Supporting citations had high precision and low recall, while mentioning citations had high recall and low precision. F-measures ranged between 0.0 and 0.58, representing low classification accuracy.
Conclusions: In our sample, the overall accuracy of scite's assessments was low. scite was less able to classify supporting and contrasting citations, and instead labeled them as mentioning. Although there is potential and enthusiasm for AI to make engagement with literature easier and more immediate, the results generated from AI differed significantly from the human interpretation.
Françoise Choay sob a ótica do arquiteto e urbanista militante Alberto Magnaghi
Authors: Campello Cabral Renata , Monteiro de Andrade Carlos Roberto 
Published: September 2023

Este artigo comenta o texto de Alberto Magnaghi publicado neste número da revista Paranoá com o título “Apresentação: um urbanista às voltas com Françoise Choay”. Visa reconhecer os vínculos entre a filósofa francesa e o arquiteto italiano, fundador da escola territorialista italiana. Ressalta a dimensão antropológica que o posicionamento de ambos compartilha diante do ambiente construído.
Law Enforcement Revitalization In Indonesia
Authors: Iswandi  
Published: September 2023

Abstract
The purpose of this article is to observe and see the law enforcement process and its implications for the state. Law enforcement has shown a negative trend towards indexation of democracy, which is getting worse because law enforcement is not right on target and enforcement does not consider the ethics of law enforcement. This research is normative research. This study only departs from the literature in accordance with the research as a source of information. The results of this study are that law enforcement that its image towards the community does not show the ethics of law enforcement and considers the position of Human Rights (HAM) so that the law enforcement process has implications for non-compliance with applicable norms and codes of ethics.
Abstrak
Tujuan artikel ini untuk mengamati dan melihat proses penegakan hukumu serta implikasinya terhadap negara. penegakan hukum hingga saat menunjukkan tren negaif terhadap indeksasi demokrasi semakin mundur akibat penegakan hukum tidak tepat sasaran dan penegakan tidak mempertimbangkan etika penegakan hukum. Penelitian ini adalah penelitian normatif. Penelitian ini hanya bertolak pada literatur sesuai dengan penelitian sebagai sumber informasi. Hasil penelitian ini bahwa penegakan hukum bahwa citranya terhadap masyarakat tidak memperlihakan mengedapan etik penegakan hukum serta mempertimbangan kedudukan Hak Asasi Manusia (HAM) sehingga proses penegakan hukum berimplikasi terhadap ketidakpatuhan pada norma-norma berlaku serta kode etik
Viabilidade da aplicação de termossifão bifásico para resfriamento passivo de ambientes internos
Authors: Almeida Fernando da Silva , Brandalise Mariane Pinto , Fuso Luciano Serconek , Cisterna Luis Hernán Rodríguez , Mantelli Marcia Barbosa Henriques , Mizgier Martin Ordenes 
Published: September 2023

Pesquisas evidenciam que está em curso um aquecimento global irreversível até o fim deste século. Tal elevação de temperaturas do planeta aumenta ainda mais a necessidade de resfriamento de ambientes internos em edifícios, onde deve se empregar tecnologias mais efetivas em termos de consumo de energia. Neste contexto, métodos de arrefecimentos passivos devem ser investigados. O presente trabalho tem como objetivo avaliar a viabilidade da aplicação de termossifões bifásicos como estratégia para resfriamento de ambientes internos. Para isso, por meio de um estudo experimental, foi utilizada uma célula-teste, integrada com uma serpentina de cobre que simulou a seção evaporadora de um termossifão. A temperatura da serpentina foi mantida prescrita e uniforme ao longo de seu comprimento por um banho de temperatura controlada. No geral, pôde-se observar que o dispositivo se mostrou capaz de extrair calor de forma passiva do ambiente, reduzindo significativamente a temperatura do ar interno. Grande parte do calor foi extraído na primeira hora e, em alguns casos, na primeira hora e meia de testes. Contudo, a transferência do calor interno foi deficiente em situações em que a diferença de temperaturas entre a serpentina e a célula foi igual ou inferior a 7°C. A distribuição da temperatura do ar interno mostrou ser similar para todos os ensaios realizados, sendo mais alta nos quadrantes superiores da célula. Além disso, velocidade de estabilização das temperaturas das superfícies internas reduziu quando a temperatura da serpentina de cobre aumentou.
An early intersemiotic translator of Milton in Brazil
Authors: Sá Luiz Fernando Ferreira , Andrade Miriam Piedade Mansur 
Published: September 2023

This article provides the commented English translation of an ode (“To Milton”, composed of twelve stanzas) by the 18th-century Brazilian poet, Claudio Manuel da Costa. Our interpretation of the translated poem problematizes the fact that da Costa did not translate Milton’s works, but that he wrote an intersemiotic translation of Milton’s contributions to literature as a whole. “To Milton” concentrates and expands on themes related to Paradise Lost (hell and heaven, heavenly muses and earthly glory, civil wars and epic battles). Although there were no translations of Milton’s works into Brazilian Portuguese then, the ode illustrates the principles of intersemiotic translation, through which semantic expansions occur in the exercise of da Costa’s choices to invite Milton to participate in a nascent literary tradition; he approaches Milton as an author comparable to Camões and Torquato Tasso. Furthermore, we address the following questions: what does the commented translation reveal about Milton’s poetry that has not been as readily visible or legible? What was accomplished by bringing Milton into 18th-century Brazilian Portuguese? How is Milton accommodated to 18th-century Brazil and how is this new environment, prospectively or actually, different for having Milton in it?
VIVÊNCIAS INTERSUBJETIVAS DE SOFRIMENTO NO TRABALHO DE MULHERES NO SETOR AUTOMOBILÍSTICO: ANÁLISE À LUZ DA PSICODINÂMICA DO TRABALHO
Authors: Lima Flávia Traldi de , Del Bianco Giuliana Sanches , Gemma Sandra Francisca Bezerra 
Published: September 2023

Este artigo tem como objetivo analisar as vivências intersubjetivas de sofrimento no trabalho de mulheres no setor automotivo. A pesquisa foi baseada em um estudo de caso com 24 trabalhadoras de uma indústria automotiva localizada no interior de São Paulo. Foram realizadas entrevistas semiestruturadas e aplicação de questionário online, sendo que os dados foram tratados por meio de Análise de conteúdo e articulados às contribuições teóricas da Psicodinâmica do Trabalho. Quanto aos resultados, evidenciou-se que a empresa totaliza uma força de trabalho majoritariamente masculina (92%) que reforça uma clara divisão social e sexual do trabalho na cadeia de trabalho automotiva. A dinâmica organizacional culmina na dificuldade das mulheres conciliar trabalho produtivo e reprodutivo para continuar se desenvolvendo na carreira. Questionamentos sobre a competência, sobretudo em relação às mulheres que ocupam cargos de liderança e formas assédio moral foram visualizados na pesquisa. Aproximadamente 68,4% das trabalhadoras, independentemente da função que ocupavam, mencionaram igualmente sentir estresse e ansiedade, ou seja, manifestações de sofrimento no trabalho. Enquanto mecanismo de defesa, a pesquisa demonstrou que as trabalhadoras desenvolvem estratégias e comportamentos para serem aceitas e provar que são capazes o suficiente para ocupar seus cargos na organização.