bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Characterization, Acute Dermal Toxicity, Anti-inflammatory, and Wound Healing Potential of Biogenic Silver Nanoparticles in Balb C Mice
Authors: Andleeb Saiqa , Iqbal epub , Gulzar Nazia , Raza Abida , Ahmad Ashfaq 
Published: July 2023

Aim:The current study aimed to develop an economic plant-based therapeutic agent to improve the treatment strategies for diseases at the nano-scale.Method:In the current research, silver nanoparticles were synthesized using Trillium govanianum aqueous extract. Characterizations were done using UV–visible spectrophotometer, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. In vivo biological activities such as acute dermal toxicity, wound healing, and anti-inflammatory were done on Balb C mice. Absorbance at 295 nm corresponds to the out-of-plane quadrupole Plasmonresonance while at 350 nm corresponds to in-plane dipole resonance. SEM images showed the morphology of TGAgNPs is not exactly spherical while XRD analysis shows that highly crystalline TGAgNPs with an average size of 27.94 nm. The FTIR spectrum represents sharp peaks of aldehyde, amide I, aromatic rings, and polysaccharides. The microscopic assessment did not find any epidermal and dermal layer abnormalities in Blab C mice when exposed to TGAgNPs during acute dermal toxicity.Result & Discussion:Results revealed that 1000 mg/kg is not a lethal dose. In the wound healing activity, no mortality and no abnormal signs were observed when petroleum jelly, nitrofuranose, TGaqu, and TGAgNPs-based ointments were applied. Enhanced epithelization was recorded in TGaqu and TGAgNPs treated mice (p≤0.001). The wound contraction percentage was higher in nitrofuranose-treated mice (74%) followed by TGAgNPs (71%), and TGaqu (69%) compared to vehicle-treated and open-wounded mice. The paw edema model proved the potential use of TGAgNPs and TGaqu as anti-inflammatory agents.Conclusion:Hence, the results proved that both TGaqu and TGAgNPs are not toxic and possessed strong anti-inflammatory and wound-healing effects due to the presence of phytochemical constituents and could be used in various drug production as a therapeutic agent.
Microtubules and Cell Division: Potential Pharmacological Targets in
Cancer Therapy
Authors: Sebastian Jomon , Rathinasamy Krishnan 
Published: July 2023

Abstract:
Microtubules are a well-known target in cancer chemotherapy because of their critical
role in cell division. Chromosome segregation during mitosis depends on the establishment of the
mitotic spindle apparatus through microtubule dynamics. The disruption of microtubule dynamics
through the stabilization or destabilization of microtubules results in the mitotic arrest of the cells.
Microtubule-targeted drugs, which interfere with microtubule dynamics, inhibit the growth of cells
at the mitotic phase and induce apoptotic cell death. The principle of microtubule-targeted drugs is
to arrest the cells at mitosis and reduce their growth because cancer is a disease of unchecked cell
proliferation. Many anti-microtubule agents produce significant inhibition of cancer cell growth
and are widely used as chemotherapeutic drugs for the treatment of cancer. The drugs that interact
with microtubules generally bind at one of the three sites vinblastine site, taxol site, or colchicine
site. Colchicine binds to the interface of tubulin heterodimer and induces the depolymerization of
microtubules. The colchicine binding site on microtubules is a much sought-after target in the history
of anti-microtubule drug discovery. Many colchicine-binding site inhibitors have been discovered,
but their use in the treatment of cancer is limited due to their dose-limiting toxicity and resistance
in humans. Combination therapy can be a new treatment strategy to overcome these drawbacks
of currently available microtubule-targeted anticancer drugs. This review discusses the significance
of microtubules as a potential pharmacological target for cancer and stresses the necessity of
finding new microtubule inhibitors to fight the disease.
Genome-wide Association Studies of REST Gene Associated Neurological
Diseases/traits with Related Single Nucleotide Polymorphisms
Authors: Wang Jingjing , Roy Sagor Kumar , Richard Seidu A. , Xu Yuming 
Published: July 2023

Background:
Genome-wide association studies (GWAS) have been used to explore the
connections between genotypes and phenotypes by comparing the genotype frequencies of genetic
changes in individuals with similar origins but distinct traits.

Objectives:
The aim is to employ the GWAS catalog to identify and investigate the various correlations
between genotypes and phenotypes of the REST gene.

Methods:
In this study, we utilized a large dataset of GWAS comprising 62,218,976 individuals in
112 studies and 122 associations with 122 traits (www.ebi.ac.uk/gwas/genes/REST) from European,
Asian, Hispanic, African ancestry up to 28 February 2023. Protein-association network evaluation
and gene ontology enrichment study was utilized to evaluate the biological function of the
discovered gene modules.

Results:
We identified several associations for both neurodevelopmental and neurodegenerative
disorders linked to REST, as well as its mapped gene modules and their functional relationship
networks.

Conclusion:
This work offers fresh insights into identifying risk loci of neurological disorders
caused by REST.
Phytochemical, Geographical, and Pharmacological Retrospect of Genus Torilis
Authors: Nasreen Noshin , Semmar Nabil , Farman Muhammad , Lacaille-Dubois Marie-Aleth , Ahmed Naseem Saud 
Published: July 2023

Background:Genus Torilis (Apiaceae) known as hedge parsley, encompasses 11-13 species distributed worldwide and shows potential pharmacological uses. Its phytochemical pattern is highly diversified including many phenolic and terpenic compounds.Objective:This research-review provides new highlighting of structural organizations, structure-activity trends, taxonomical, tissue and geographical distribution of phytocompounds of Torilis ge-nus from extensive statistical analyses of available data.Method:In extenso, exploration of documented literature and statistical data analyses were applied to update the phytochemical pool of the genus under several aspects including structural diversity, geographical distribution, biological compartmentations and pharmacological activities.Results:Phytoconstituents were classified into homogeneous clusters that revealed to be associated with chemical constitutions (aglycone types, chemical groups) and distributions (through species, tissues, geographical). About bioactivities, terpenes were studied from a pharmacological point of view with relatively high frequencies for antifungal, antibacterial, cytotoxic and anti-inflammatory activities. Preliminary structure-activity relationships were highlighted implying opposite effects between hydroxylation and methylation in favor of different activities. Crude extracts and isolated compounds have shown several biological activities (antibacterial, anticancer, antiangiogenic, anti-proliferative, etc.), thus providing authentic scientific proof for their diverse uses in folk medicines.Conclusion:The phytochemistry of the genus Torilis promises important perspectives in matters of pharmacological activities. These perspectives call for further investments in pharmacology because of (i) unbalance between phenolic and terpenic compounds according to the countries and (ii) more advanced current states of structural elucidations compared to biological evaluations.
Physicochemical Significance of Topological Indices: Importance in Drug
Discovery Research
Authors: Bhatia Karanpreet Singh , Gupta Ankit Kumar , Saxena Anil Kumar 
Published: July 2023

Background:
Quantitative Structure-Activity Relationship (QSAR) studies describing the correlations between biological activity as dependent parameters and physicochemical and structural descriptors, including topological indices (TIs) as independent parameters, play an important role in drug discovery research. The emergence of graph theory in exploring the structural attributes of the chemical space has led to the evolution of various TIs, which have made their way into drug discovery. The TIs are easy to compute compared to the empirical parameters, but they lack physiochemical interpretation, which is essential in understanding the mechanism of action

Objective:
Hence, efforts have been made to review the work on the advances in topological indices, their physicochemical significance, and their role in developing QSAR models.

Methods:
A literature search has been carried out, and the research article providing evidence of the physicochemical significance of the topological parameters as well as some recent studies utilizing these parameters in the development of QSAR models, have been evaluated.

Result:
In this review, the physicochemical significance of TIs have been described through their correlations between empirical parameters in terms of explainable physicochemical properties, along with their application in the development of predictive QSAR models.

Conclusion:
Most of these findings suggest a common trend of TIs correlation with MR rather than logP or other parameters; nevertheless, the developed models may be useful in both drug and vaccine development.
Patient and Clinician Perceptions of the Pulse Oximeter in a Remote Monitoring Setting for COVID-19: Qualitative Study
Authors: Torres-Robles Andrea , Allison Karen , Poon Simon K , Shaw Miranda , Hutchings Owen , Britton Warwick J , Wilson Andrew , Baysari Melissa 
Published: July 2023

Background
As a response to the COVID-19 pandemic, the Sydney Local Health District in New South Wales, Australia, launched the rpavirtual program, the first full-scale virtual hospital in Australia, to remotely monitor and follow up stable patients with COVID-19. As part of the intervention, a pulse oximeter wearable device was delivered to patients to monitor their oxygen saturation levels, a critical indicator of COVID-19 patient deterioration. Understanding users’ perceptions toward the device is fundamental to assessing its usability and acceptability and contributing to the effectiveness of the intervention, but no research to date has explored the user experience of the pulse oximeter for remote monitoring in this setting.

Objective
This study aimed to explore the use, performance, and acceptability of the pulse oximeter by clinicians and patients in rpavirtual during COVID-19.

Methods
Semistructured interviews and usability testing were conducted. Stable adult patients with COVID-19 (aged ≥18 years) who used the pulse oximeter and were monitored by rpavirtual, and rpavirtual clinicians monitoring these patients were interviewed. Clinicians could be nurses, doctors, or staff who were part of the team that assisted patients with the use of the pulse oximeter. Usability testing was conducted with patients who had the pulse oximeter when they were contacted. Interviews were coded using the Theoretical Framework of Acceptability. Usability testing was conducted using a think-aloud protocol. Data were collected until saturation was reached.

Results
Twenty-one patients (average age 51, SD 13 years) and 15 clinicians (average age 41, SD 11 years) completed the interview. Eight patients (average age 51, SD 13 years) completed the usability testing. All participants liked the device and thought it was easy to use. They also had a good understanding of how to use the device and the device’s purpose. Patients’ age and device use–related characteristics (eg, the warmth of hands and hand steadiness) were identified by users as factors negatively impacting the accurate use of the pulse oximeter.

Conclusions
Patients and clinicians had very positive perceptions of the pulse oximeter for COVID-19 remote monitoring, indicating high acceptability and usability of the device. However, factors that may impact the accuracy of the device should be considered when delivering interventions using the pulse oximeter for remote monitoring. Targeted instructions about the use of the device may be necessary for specific populations (eg, older people and patients unfamiliar with technology). Further research should focus on the integration of the pulse oximeter data into electronic medical records for real-time and secure patient monitoring.
Digital Phenotyping for Monitoring Mental Disorders: Systematic Review
Authors: Bufano Pasquale , Laurino Marco , Said Sara , Tognetti Alessandro , Menicucci Danilo 
Published: July 2023

Background
The COVID-19 pandemic has increased the impact and spread of mental illness and made health services difficult to access; therefore, there is a need for remote, pervasive forms of mental health monitoring. Digital phenotyping is a new approach that uses measures extracted from spontaneous interactions with smartphones (eg, screen touches or movements) or other digital devices as markers of mental status.

Objective
This review aimed to evaluate the feasibility of using digital phenotyping for predicting relapse or exacerbation of symptoms in patients with mental disorders through a systematic review of the scientific literature.

Methods
Our research was carried out using 2 bibliographic databases (PubMed and Scopus) by searching articles published up to January 2023. By following the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, we started from an initial pool of 1150 scientific papers and screened and extracted a final sample of 29 papers, including studies concerning clinical populations in the field of mental health, which were aimed at predicting relapse or exacerbation of symptoms. The systematic review has been registered on the web registry Open Science Framework.

Results
We divided the results into 4 groups according to mental disorder: schizophrenia (9/29, 31%), mood disorders (15/29, 52%), anxiety disorders (4/29, 14%), and substance use disorder (1/29, 3%). The results for the first 3 groups showed that several features (ie, mobility, location, phone use, call log, heart rate, sleep, head movements, facial and vocal characteristics, sociability, social rhythms, conversations, number of steps, screen on or screen off status, SMS text message logs, peripheral skin temperature, electrodermal activity, light exposure, and physical activity), extracted from data collected via the smartphone and wearable wristbands, can be used to create digital phenotypes that could support gold-standard assessment and could be used to predict relapse or symptom exacerbations.

Conclusions
Thus, as the data were consistent for almost all the mental disorders considered (mood disorders, anxiety disorders, and schizophrenia), the feasibility of this approach was confirmed. In the future, a new model of health care management using digital devices should be integrated with the digital phenotyping approach and tailored mobile interventions (managing crises during relapse or exacerbation).
IDENTIFIKASI STRUKTUR LAPISAN TANAH PADA LAHAN GAMBUT DENGAN METODE RESISTIVITAS KONFIGURASI WENNER-SCHLUMBERGER
Authors: Sapina Ega , Handayani Linda , Pebralia Jesi 
Published: July 2023

Tanah gambut memiliki karakterisitik kandungan air dan kompresebilitasnya tinggi menyebabkan gambut rentan terjadi penurunan permukaan tanah ketika ada pembebanan. Penelitian ini bertujuan untuk menganalisis ketebalan lapisan tanah gambut di Desa Pandan Jaya Kecamatan Geragai Kabupaten Tanjung Jabung. Metode yang digunakan adalah metode geolistrik resistivitas konfigurasi Wenner-Schlumberger dengan sebanyak 4 lintasan pengukuran masing-masing 110 meter dengan jarak antar elektroda 10 meter. Dari hasil pengukuran resistivitas diperoleh bahwa lapisan gambut di Desa Pandan Jaya Kecamatan Geragai Kabupaten Tanjung Timur memiliki nilai resistivitas mulai dari 5,03 Ωm hingga 130 Ωm. Dapat disimpulkan lapisan gambut pada lokasi penelitian memiliki ketebalan antara 5 m hingga 7 m. Informasi ini sangat penting untuk pertimbangan kedalaman pondasi saat akan mendirikan bangunan di daerah tersebut.
Geometric, landmark-guided technique reduces tissue trauma, surgery time, and subjective difficulty for canine peripheral lymphadenectomies: an educational crossover study
Authors: Worden Natalie J. , Bertran Judith , Reynolds Penny S. , Chase Ellis C. , Crews Chiquitha D. , Ham Kathleen , de Mello Souza Carlos H. , Regier Penny J. , Adin Christopher A. , Maxwell Elizabeth A. 
Published: July 2023

Abstract

OBJECTIVE
To compare the effect of a geometric, landmark-guided lymphadenectomy (LL) approach to peripheral lymph nodes (LNs) on successful LN identification, surgical time, tissue trauma, and ease of LN identification compared to standard lymphadenectomy (SL) and methylene blue–guided lymphadenectomy (MBL).

SAMPLE
18 adult, mixed-breed canine cadavers operated on by 7 veterinarians and 5 fourth-year veterinary students between July 23 and October 12, 2022.

METHODS
Participants were provided standardized, publicly available materials regarding the anatomy and surgical techniques for SL of 3 peripheral lymphocentrums: superficial cervical, axillary (ALN), and superficial inguinal (SILN). Participants performed the 3 SLs unilaterally on canine cadavers. Thereafter, they were randomly assigned to 2 crossover groups: MBL and LL. All dissections were separated by at least 2 weeks for each participant. Primary outcome measures included successful LN identification, surgical time, tissue trauma scores, and subjective difficulty.

RESULTS
Successful LN identification was highest with LL (86%) compared to SL (69%) and MBL (67%). Subjective difficulty scores were reduced with LL for SILN dissections. Tissue trauma scores were reduced when using LL for ALN and SILN compared to MBL and SL. Time to LN identification was reduced for ALN with LL. No significant differences were observed between MBL and SL, or for the superficial cervical dissections.

CLINICAL RELEVANCE
Peripheral lymphadenectomies are time consuming and difficult for veterinarians in early stages of surgical training. Little surgical guidance is provided within current literature. Geometric, landmark-guided lymphadenectomies may improve LN identification success and reduce surgical time, tissue trauma, and procedure difficulty, which could encourage their clinical application.
Oral voriconazole therapy in cats with histoplasmosis yielded mild side effects and a favorable outcome
Authors: Easterwood Loren F. , Harkin Kenneth R. , Rankin Amy J. 
Published: July 2023

Abstract

OBJECTIVE
Infection by Histoplasma organisms most commonly results in disseminated systemic infection in cats. Relapse during therapy with itraconazole and fluconazole has been reported. The aim of this study was to report the clinical response, duration of therapy, side effects, and outcome in cats with histoplasmosis that were treated with voriconazole.

ANIMALS
6 client-owned cats.

CLINICAL PRESENTATION
Medical records were reviewed of cats with confirmed histoplasmosis that presented to the Kansas State University Veterinary Health Center and received voriconazole therapy (n = 6 cats).

RESULTS
4 cats were switched to voriconazole from fluconazole (n = 2), itraconazole (1), or both (1), and 2 cats received voriconazole as initial therapy. Median starting dosage was 3.51 mg/kg PO every 72 hours. Two cats required a change in dosing interval from every 72 hours to every 96 hours due to hyporexia (n = 2) and an elevated ALT (1). Remission was documented in all 6 cats with a median time to a negative urine antigen of 256 days (range, 94 to 494 days).

CLINICAL RELEVANCE
Voriconazole therapy in 6 cats with histoplasmosis yielded mild side effects and a favorable outcome. Reported dosages provide a feasible alternative to daily dosing for owners of feline patients.
On uniform dichotomy in mean of stochastic skew-evolution semiflows in Banach spaces
Authors: Fülöp Tímea Melinda Személy 
Published: July 2023

Abstract
In this paper we consider three concepts of uniform dichotomy in mean for stochastic skew-evolution semiflows: uniform exponential dichotomy in mean, uniform polynomial dichotomy in mean and uniform h- dichotomy in mean. Some characterizations of these notions and connections between these concepts are given. The obtained results can be considered generalizations to the dichotomy case of the results from [29].
Price calculation of wooden bariatric beds
Authors: Hitka Miloš , Lorincová Silvia , Kajanová Jana , Štarchoň Peter , Sydor Maciej 
Published: July 2023

Abstract
In the field of interior and furniture, the pursuit of comfort has always been based on the anthropometric dimensions of the user. When optimizing the dimensions of the bed for the needs of today’s population, we start from the forecasted values of the relevant body dimensions, i.e. height and weight. Based on previous research, we can conclude that the anthropometric dimensions of the adult Slovak population after reaching the age of adulthood have increased statistically significantly by approx. 4.5–5% since the last measurements in 1987, from the point of view of the body growth process. In connection with the aforementioned findings, it is necessary for furniture companies producing bed furniture to adjust their calculation procedures for price formation depending on the needs of users, in order to forecast their financial situation. The goal of the work is to determine the cost increase for bariatric respondents, based on the determined dimensions of the wooden bed compared to a standard manufactured bed, and to determine the calculation formula for single-piece production. The results show that increasing the dimensions of the bed will increase the total costs by approximately 70%.
СТУДЕНТСЬКА АУДИТОРІЯ МИХАЙЛА ГРУШЕВСЬКОГО ФІЛОСОФСЬКОГО ФАКУЛЬТЕТУ ЛЬВІВСЬКОГО УНІВЕРСИТЕТУ: СКЛАД ТА ДИНАМІКА
Authors: ТЕЛЬВАК Віталій , ЖУРАВЛЬОВ Святослав , ВЛАДИГА Ольга 
Published: July 2023

Анотація. Мета статті полягає у з’ясуванні кількісних характеристик, динаміки та національного складу студентської аудиторії М. Грушевського. Методологічне підґрунтя становить міждисциплінарний підхід. Особливий акцент зроблено на структурно-функціональному системному аналізі історіографічних фактів і порівняльно-історичному методі, виходячи з принципів об’єктивності й історизму. Наукова новизна статті полягає у спробі комплексного аналізу студентської аудиторії М. Грушевського. Висновки. Відзначено, що студентські каталоги філософського факультету Львівського університету постають найбільш вагомим джерелом для з’ясування особливостей науково-педагогічної праці М. Грушевського у галицьку добу його життя. Важливість цього документа полягає в тому, що завдяки його інформаційному потенціалу питання, в обговоренні яких раніше домінувала емоційно-спекулятивна складова, тепер отримали фактологічне підґрунтя для всебічного історіографічного аналізу. Так, здобута на підставі опрацювання каталогів інформація дає підставу переконливо атестувати М. Грушевського як популярного викладача не тільки серед української, але й польської і єврейської молоді. Більшість її представників стали помітними діячами того часу, популяризуючи чи трансформуючи отримані на студентській лаві історичні знання. Також вдалося з’ясувати національну та гендерну специфіку студентської аудиторії українського професора, відтворити різноплановість його дидактичних пропозицій, простежити фреквенцію відвідуваності різних курсів тощо. Отже, саме завдяки опрацьованим студентським каталогам М. Грушевський постає авторитетним і діяльним представником львівської університетської корпорації.