bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in enteropathogen control throughout the meat chicken production chain
Authors: Stewart Jack , Pavic Anthony 
Published: April 2023

AbstractEnteropathogens, namelySalmonellaandCampylobacter, are a concern in global public health and have been attributed in numerous risk assessments to a poultry source. During the last decade, a large body of research addressing this problem has been published. The literature reviewed contains review articles on certain aspects of poultry production chain; however, in the past decade there has not been a review on the entire chain—farm to fork—of poultry production. For this review, a pool of 514 articles were selected for relevance via a systematic screening process (from >7500 original search articles). These studies identified a diversity of management and intervention strategies for the elimination or reduction of enteropathogens in poultry production. Many studies were laboratory or limited field trials with implementation in true commercial operations being problematic. Entities considering using commercial antienteropathogen products and interventions are advised to perform an internal validation and fit‐for‐purpose trial asSalmonellaandCampylobacterserovars and biovars may have regional diversity. Future research should focus on nonchemical application within the processing plant and how a combination of synergisticinterventions through the production chain may contribute to reducing the overall carcass burden of enteropathogens, coupled with increased consumer education on safe handling and cooking of poultry.
Who benefits from (Human Resource Management) professionalization? The moderating role of gender on professionalization effects in organisations
Authors: Scheibmayr Isabella , Reichel Astrid 
Published: April 2023

AbstractProfessionalization aims at closure, that is, having the monopoly protection of expertise for an occupation on the labour market and in organizations. Role congruity theory suggests that the translation of professionalization into organizational closure and reaching board membership is likely to be moderated by gender at the individual and the occupational level. We test this proposition focusing on Human Resource Management (HRM), an occupation with a long history of professionalization attempts. Using a sample of 3276 organizations embedded in 34 countries with varying professionalization levels between countries, results show that professionalization of HRM at the country level is positively related to closure in organizations. The positive relationship is weaker for female HR directors and high proportions of women in the HRM occupation in a country. Organizational closure, in contrast, is negatively related to board representation but increases the likelihood of board membership in countries with high proportions of women in the HRM occupation.
A qualitative look at perception and experience of sodium reduction strategies in the food industry through focus groups and individual interviews
Authors: Dunteman Aubrey N. , Lee Youngsoo , Lee Soo‐Yeun 
Published: April 2023

AbstractThe high incidence of sodium overconsumption in the general population has led sodium reduction in commercial food products to become a topic of importance in the food industry. In order to bridge the gap between sodium reduction understanding in the food industry and academia, focus groups and individual interviews of food industry professionals were conducted. Sodium reduction and influence from external entities such as federal regulations and consumer insight were prominent in the nutritional concerns of food industry professionals. A large variety of sodium reduction strategies were introduced with discussion on the many factors that contribute to their potential for success. Flavor modification methods were most prevalent in the discussion, with particular focus on potassium chloride and incorporating umami taste. Factors that frequently positively contributed to a strategy's success include maintaining functionality and/or important sensory attributes, inexpensive to implement, and being perceived as clean label. Conversely, factors that negatively affect success include adversely impacting flavor, being considered not clean label, and high costs of implementation. Foods important for future sodium reduction varied widely, although those were largely products with high sodium density. Future efforts toward reducing sodium overconsumption and sodium content in the food supply fell into three categories: consumer‐focused, industry‐focused, and research‐focused. Of particular importance for future efforts included greater regulatory pressure and more consumer nutritional education. Findings suggest that future efforts to reduce the incidence of sodium overconsumption should be carried out through multiple avenues rather than focusing on the agency of consumers, the food industry, or research alone.
Comparative analysis of the efficacy and safety of electromagnetic navigation bronchoscopy combined with x‐ray or radial endobronchial ultrasound biopsy in the diagnosis of small peripheral pulmonary nodules
Authors: Fu Yifan , Yuan Xinyu , Pan Wenyin , Lu Yijie , Zeng Daxiong , Jiang Junhong 
Published: April 2023

AbstractObjectiveTo compare the clinical value and safety of electromagnetic navigation bronchoscopy (ENB) combined with radial endobronchial ultrasound (R‐EBUS) or x‐ray in the diagnosis of small peripheral pulmonary nodules that cannot be diagnosed by conventional bronchoscopy.MethodsFifty‐six patients with peripheral pulmonary nodules of <3 cm in diameter who underwent bronchoscopy at the First Affiliated Hospital of Soochow University and Dushu Lake Hospital of Soochow University from February 2019 to January 2022 were selected as the study subjects, including 24 patients who underwent ENB combined with x‐ray and 32 patients who underwent ENB combined with R‐EBUS. ENB was used as the guiding method in both groups, and x‐ray group and R‐EBUS group were combined with x‐ray and R‐EBUS, respectively, to determine whether the lesion was reached. In x‐ray group, biopsy and brushing were performed under fluoroscopic guidance. Using the results of surgery, puncture pathology, or clinical follow‐up 1 year as the gold standard, the diagnostic sensitivity, specificity, negative predictive value (NPV), diagnostic yield, negative likelihood ratio (LR‐), Youden index, missed diagnosis rate, success rate, and κ value were compared between the two groups, and the occurrence of postoperative complications was also compared between the two groups.ResultsThe negative predictive value of the R‐EBUS group was significantly better than that of the x‐ray group (p = 0.006).ConclusionEven with smaller nodule diameters, the negative predictive value of ENB combined with R‐EBUS were still higher than that of the x‐ray group.
Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors
Authors: Matsuo Norikazu , Azuma Koichi , Murotani Kenta , Murata Daiki , Matama Goushi , Kawahara Akihiko , Kojima Takashi , Tokito Takaaki , Hoshino Tomoaki 
Published: April 2023

AbstractBackgroundThe presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood. Therefore, we examined whether cancer cachexia affects the prognosis of patients with non‐small cell lung cancer (NSCLC) treated with PD‐1/PD‐L1 inhibitors.MethodsWe retrospectively screened patients with pathologically confirmed advanced or recurrent NSCLC who were treated with PD‐1/PD‐L1 monotherapy at Kurume University Hospital. We defined cancer cachexia as weight loss of at least 5% during the past 6 months or any degree of weight loss more than 2% and BMI <20.ResultsAmong 182 patients, 74 had cancer cachexia. The presence of cachexia was significantly associated with females, poor performance status (PS), never‐smokers, and driver mutations. Multivariate analysis revealed that poor PS and being a smoker were associated with the presence of cachexia. Patients with cancer cachexia had significantly shorter progression‐free survival (PFS) and overall survival (OS). In the multivariate analysis, PS and sex were significantly correlated with PFS, whereas PS and cachexia were significantly correlated with OS. Subanalysis revealed that patients in the PS0/without cachexia group had longer PFS and OS than those in the cachexia or PS1‐3 group.ConclusionsIn NSCLC patients, cachexia was associated with a worse prognosis, irrespective of tumor PD‐L1 expression, indicating that cachexia is a predictive factor for NSCLC patients receiving immune checkpoint inhibitors.
Prognostic analysis of the plasma fibrinogen combined with neutrophil‐to‐lymphocyte ratio in patients with non–small cell lung cancer after radical resection
Authors: Wang Gao‐Xiang , Huang Zhi‐Ning , Ye Ying‐Quan , Tao Shan‐Ming , Xu Mei‐Qing , Zhang Mei , Xie Ming‐Ran 
Published: April 2023

AbstractBackgroundTo investigate the correlation between the fibrinogen combined with neutrophil‐to‐lymphocyte ratio (F‐NLR) and the clinicopathologic features of non–small cell lung cancer (NSCLC) patients who underwent radical resection.MethodsThis study reviewed the medical records of 289 patients with NSCLC who underwent radical resection. The patients were stratified into three groups based on F‐NLR as follows: patients with low NLR and fibrinogen were group A, patients with high NLR or fibrinogen were group B, and patients with high NLR and fibrinogen were group C. Receiver operating characteristic curve and Youden index were used to determine the cutoff value of the NLR and fibrinogen. Survival curves were described by Kaplan–Meier method and compared by log‐rank test. The univariate and multivariate analyses were performed with the Cox proportional hazard model to identify the prognostic factors.ResultsA value of 3.19 was taken as the optimal cutoff value of NLR in this study. A value of 309 was used as the optimal cutoff value of fibrinogen. Cox multivariate analysis showed that tumor, nodes, metastasis (TNM) stage and F‐NLR were independent prognostic factors affecting the survival rate of patients. The first‐, third‐, and fifth‐year survival rates in group A were 99.2%, 96.6%, and 95.0%, respectively. The first‐, third‐, and fifth‐year survival rates in group B were 98.4%, 76.6%, and 63.2%, respectively. The first‐, third‐, and fifth‐year survival rates in group C were 91.3%, 41.1%, and 22.8%, respectively. F‐NLR was significantly correlated with overall survival in patients with NSCLC (p < 0.001).ConclusionsThe F‐NLR level is markedly related to the prognosis of patients with NSCLC undergoing radical surgery. Therefore, closer attention should be given to patients with NSCLC with a high F‐NLR before surgery to provide postoperative adjuvant therapy.
In vivo reflectance confocal microscopy findings in a case of atypical fibroxanthoma
Authors: Duman Nilay , Yaman Banu , Oraloğlu Göktürk , Karaarslan Işıl 
Published: April 2023

AbstractClinical and dermoscopic features of atypical fibroxanthoma (AFX) are mostly non‐diagnostic, so other in vivo diagnostic tools may give additional clues for accurate clinical diagnosis, such as in vivo reflectance confocal microscopy (RCM). However, there has been scarce data on RCM features of AFX in the literature, in only clear cell type. Herein we present a case of epithelioid cell predominant type AFX with RCM findings.
Review article: Risk of cardiovascular events in patients with inflammatory bowel disease receiving small molecule drugs
Authors: Olivera Pablo A. , Lasa Juan S. , Peretto Giovanni , Zuily Stephane , Danese Silvio , Peyrin‐Biroulet Laurent 
Published: April 2023

SummaryBackgroundIn the context of an ageing inflammatory bowel disease (IBD) population, cardiovascular comorbidities become particularly relevant. Novel small molecule drugs (SMDs) for the treatment of moderate‐to‐severe IBD have been recently approved, including Janus kinase (JAK) inhibitors and sphingosine‐1‐phosphate receptor (S1P) modulators. Data from rheumatoid arthritis population have raised concerns about the risk of cardiovascular events with the use of tofacitinib, which was extrapolated to other immune‐mediated diseases and other JAK inhibitors. S1P receptor modulation has been associated with potential cardiovascular events, especially bradycardia and cardiac conduction abnormalities.AimTo review the incidence of cardiovascular events with the use of SMDs in patients with IBD and to provide practical recommendations on mitigation strategies.MethodsPublished literature was reviewed; recommendations were synthesised by experts in both cardiovascular diseases and IBD.ResultsEvidence from the IBD population does not indicate a higher risk of cardiovascular events with tofacitinib and other JAK inhibitors. The risk is higher in patients with intermediate to high cardiovascular risk. S1P modulators may be associated with a dose‐dependent, first‐dose effect, transient risk of conduction abnormalities (bradycardia and AV block). Screening and monitoring of cardiovascular risk factors should be done in all patients with IBD. Risk stratification for cardiovascular disease should be performed before starting treatment with SMDs.ConclusionsAvailable evidence of both JAK inhibitors and S1P modulators indicates a reassuring safety profile of SMDs from the cardiovascular perspective in the overall IBD population. Efforts should be made to identify patients with IBD at a higher risk of cardiovascular events.
Meta‐analysis: Post‐COVID‐19 functional dyspepsia and irritable bowel syndrome
Authors: Marasco Giovanni , Maida Marcello , Cremon Cesare , Barbaro Maria Raffaella , Stanghellini Vincenzo , Barbara Giovanni 
Published: April 2023

SummaryIntroductionThe burden of post‐COVID‐19 functional dyspepsia (FD) and irritable bowel syndrome (IBS) remains unclear. The aim of this meta‐analysis was to estimate the rate of post‐COVID‐19 FD and IBS.MethodsMEDLINE, Scopus and Embase were searched through 17 December 2022. Studies reporting the incidence of FD and/or IBS in COVID‐19 survivors and controls (without COVID‐19), when available, according to the Rome criteria, were included. Estimated incidence with 95% confidence intervals (CI) was pooled. The odds ratio (OR) with 95% confidence intervals (CI) was pooled; heterogeneity was expressed as I2.ResultsTen studies met the inclusion criteria and were included in the analysis. Overall, four studies including 1199 COVID‐19 patients were considered for FD. Post‐COVID‐19 FD was reported by 72 patients (4%, 95% CI: 3%–5% and I2 0%). The pooled OR for FD development (three studies) in post‐COVID‐19 patients compared to controls was 8.07 (95% CI: 0.84–77.87, p = 0.071 and I2 = 67.9%). Overall, 10 studies including 2763 COVID‐19 patients were considered for IBS. Post‐COVID‐19 IBS was reported by 195 patients (12%, 95% CI: 8%–16%, I2 95.6% and Egger's p = 0.002 test). The pooled OR for IBS development (four studies) in COVID‐19 patients compared to controls was 6.27 (95% CI: 0.88–44.76, p = 0.067 and I2 = 81.4%); considering only studies with a prospective COVID‐19 cohort (three studies), the pooled OR was 12.92 (95% CI: 3.58–46.60, p < 0.001 and I2 = 0%).ConclusionsCOVID‐19 survivors were found to be at risk for IBS development compared to controls. No definitive data are available for FD.
New insights into the clinical characteristics of SETD2‐mutated acute myeloid leukaemia
Authors: Zhang Xiang , Wang Ziwei , Sun Jiewen , Liu Lixia , Qin Jiayue , Huang Aijie , Yang Min , Lou Yinjun , Tang Gusheng , Mao Liping , Qian Jiejin , Wei Juying , Mai Wenyuan , Meng Haitao , Yang Jianmin , Tong Hongyan , Wang Jianmin , Yu Wenjuan , Ni Xiong , Jin Jie 
Published: April 2023

SummaryAs reported, SETD2 is recurrently mutated in acute myeloid leukaemia (AML), but knowledge about the specifics is limited. We enrolled 530 consecutive newly diagnosed AML patients in our study, and we analysed the distribution pattern and prognostic role of SETD2 mutation in AML. SETD2 mutation was found to affect 6.3% of AML patients, and it frequently co‐occurred with IDH2, NRAS and CEBPA mutations. SETD2‐mutated patients saw excellent therapeutic responses but failed to gain better survival time than other patients. This could be because of the high recurrence and mortality in SETD2‐mutated patients who have additional mutations, such as NRAS mutation.
Stress buffering after physical activity engagement: An experience sampling study
Authors: Gerstberger Leo , Blanke Elisabeth S. , Keller Jan , Brose Annette 
Published: April 2023

AbstractObjectivesWhile encountering daily hassles is a normative experience, it poses a threat to individuals' daily affective well‐being. However, physical activity engagement may help to reduce the current stress‐related impact on affective well‐being (i.e. stress buffering), which we investigate in this study. Furthermore, we examined the possible moderating role of people's global stress context (i.e. exposure to major life events and chronic stress) on this within‐person stress‐buffering effect.DesignWe approached these ideas using six‐times‐a‐day experience sampling assessments over a period of 22 days.MethodsDrawing on a broad national sample of 156 middle‐aged adults from the EE‐SOEP‐IS study, we aimed to elucidate the naturally occurring within‐person dynamics of current stress, physical activity engagement, and momentary affect within individuals' everyday lives. Major life events and chronic stress were measured as between‐person variables.ResultsMultilevel analyses revealed significant within‐person associations of current stress and physical activity engagement with momentary affect. Stress‐related negative affect was lower when individuals engaged in physical activity, in accordance with the idea of a within‐person stress‐buffering effect of physical activity engagement. For individuals exposed to more severe major life events, the stress‐buffering effect of physical activity engagement for negative affect was lower. Chronic stress did not moderate the within‐person stress‐buffering effect.ConclusionsOverall, results add to the existing literature that links physical activity to increased stress resilience and emphasizes the need for taking the global between‐person stress context into account.
Access to credit and heterogeneous effects on agricultural technology adoption: Evidence from large rural surveys in Ethiopia
Authors: Regassa Mekdim D. , Degnet Mohammed B. , Melesse Mequanint B. 
Published: April 2023

AbstractModern agricultural technologies hold huge potential for increasing productivity and reducing poverty in developing countries. However, adoption levels of these technologies have remained disappointingly low in Africa. This paper analyzes the effect of access to credit on the likelihood of adoption and use intensity of chemical fertilizers using data from large rural surveys in Ethiopia. Using a heteroscedasticity‐based identification strategy to address the endogenous nature of access to credit, we find that access to credit has significant positive effects on adoption and intensity of use of chemical fertilizers. However, important heterogeneities are observed. Credit obtained from formal sources is more important for the intensity of use than for the decision to adopt chemical fertilizers. Credit taken with the primary purpose of financing agricultural inputs is more likely to promote adoption of chemical fertilizers than credit taken per se. Furthermore, reported credit effects are larger when estimated against the sample of credit‐constrained non‐users as compared with the pool of the whole sample of credit non‐users. The results remain robust to several sensitivity analyses. Our results yield useful implications for the design, promotion, and targeting of credit services to leverage their effect on adoption of agricultural technologies.
Treatment with delgocitinib cream improves itch, pain and other signs and symptoms of chronic hand eczema: Results from the Hand Eczema Symptom Diary in a phase IIb randomized clinical trial
Authors: Bauer Andrea , Thyssen Jacob P. , Buhl Timo , Nielsen Thor Schütt Svane , Larsen Lotte Seiding , Østerskov Anne Birk , Agner Tove 
Published: April 2023

AbstractBackgroundMeasuring patient‐reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE).ObjectivesTo assess the effect of delgocitinib cream on itch, pain and nine additional key signs and symptoms reported by patients with CHE using the Hand Eczema Symptom Diary (HESD).MethodsIn a double‐blind, phase IIb dose‐ranging trial (NCT03683719), 258 adults with mild to severe CHE were randomized to delgocitinib cream 1, 3, 8 or 20 mg/g or cream vehicle twice daily for 16 weeks. Patients assessed 11 signs and symptoms of CHE daily through the HESD using an 11‐point numeric rating scale; this was an exploratory endpoint.ResultsDelgocitinib cream 20 mg/g was associated with an early and sustained reduction in itch and pain, along with clinically relevant reductions of ≥4 points from baseline to Week 16 in 48.4% and 63.6% of patients, respectively (17.9% and 5.9% with cream vehicle). There were improvements versus cream vehicle in all assessed CHE signs and symptoms (20 mg/g, p < 0.05).ConclusionsDelgocitinib cream reduced itch, pain and other signs and symptoms in patients with CHE. This data correlated with clinician‐reported outcomes, indicating that the HESD may be a useful assessment tool for CHE management.
In vivo tissue pharmacokinetics of ERBB2‐specific binding oligonucleotide‐based drugs by PET imaging
Authors: Park Sun Mi , Baek Suji , Lee Jung Hwan , Woo Sang‐Keun , Lee Tae Sup , Park Hyun Soo , Lee Jongook , Kang Yeon‐Koo , Kang Seo Young , Yoo Min Young , Yoon Hai‐Jeon , Kim Bom Sahn , Lee Kang Pa , Moon Byung Seok 
Published: April 2023

AbstractAlthough aptamers have shown excellent target specificity in preclinical and clinical studies either by themselves or as aptamer‐drug conjugates, their in vivo tissue pharmacokinetic (PK) analysis is still problematic. We aimed to examine the utility of image‐based positron emission tomography (PET) to evaluate in vivo tissue PK, target specificity, and applicability of oligonucleotides. For this, fluorine‐18‐labeled aptamers with erb‐b2 receptor tyrosine kinase 2 (ERBB2)‐specific binding were synthesized by base‐pair hybridization using a complementary oligonucleotide platform. To investigate the PKs and properties of in vivo tissue, usefulness of in vivo PET imaging in the development of an oligonucleotide‐based drug as an assessment tool was evaluated in normal and tumor xenografted mice. ERBB2‐cODN‐idT‐APs‐[18F]F ([18F]1), injected intravenously showed significant and rapid uptake in most tissues except for the initial brain and muscle; the uptake was highest in the heart, followed by kidneys, liver, lungs, gall bladder, spleen, and stomach. The main route of excretion was through the renal tract ~77.8%, whereas about 8.3% was through the biliary tract of the total dose. The estimated effective dose for an adult woman was 0.00189 mGy/MBq, which might be safe. ERBB2‐positive tumor could be well visualized in the KPL4 xenograft animal model by in vivo PET imaging. Consequently, the distribution in each organ including ERBB2 expression could be well determined and quantified by PET with fluorine‐18‐labeled aptamers. In vivo PK parameters such as terminal half‐life, time to maximum concentration, area under the curve, and maximum concentration, were also successfully estimated. These results suggest that image‐based PET with radioisotope‐labeled aptamers could be provide valuable information on properties of oligonucleotide‐based drugs in drug discovery of targeted therapeutics against various diseases.