bluuebunny/crossref_metadata_2025_split huggingface dataset:
The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension
Authors: Trimarco Valentina , Manzi Maria Virginia , Izzo Raffaele , Mone Pasquale , Lembo Maria , Pacella Daniela , Esposito Giovanni , Falco Angela , Morisco Carmine , Gallo Paola , Santulli Gaetano , Trimarco Bruno 
Published: May 2023

BackgroundAdverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently reported beneficial results in BP control in patients with TRH adopting an innovative approach, defined as therapeutic concordance, in which trained physicians and pharmacists reach a concordance with patients to make them more involved in the therapeutic decision-making process.MethodsThe main scope of this study was to investigate whether the therapeutic concordance approach could lead to a reduction in ADR occurrence in TRH patients. The study was performed in a large population of hypertensive subjects of the Campania Salute Network in Italy (ClinicalTrials.gov Identifier: NCT02211365).ResultsWe enrolled 4,943 patients who were firstly followed-up for 77.64 ± 34.44 months, allowing us to identify 564 subjects with TRH. Then, 282 of these patients agreed to participate in an investigation to test the impact of the therapeutic concordance approach on ADRs. At the end of this investigation, which had a follow-up of 91.91 ± 54.7 months, 213 patients (75.5%) remained uncontrolled while 69 patients (24.5%, p &lt; 0.0001) reached an optimal BP control. Strikingly, during the first follow-up, patients had complained of a total of 194 ADRs, with an occurrence rate of 68.1% and the therapeutic concordance approach significantly reduced ADRs to 72 (25.5%).ConclusionOur findings indicate that the therapeutic concordance approach significantly reduces ADRs in TRH patients.
Case report: Use of three-dimensional technology in criss-cross heart with double outlet right ventricle
Authors: Alifu Ailixiati , Wang Haifan , Su Yuntian , Chen Renwei 
Published: May 2023

BackgroundIn this case report, we utilized a three-dimensional printing model to replicate the complex anatomy of a criss-cross heart with double outlet right ventricle—an extremely rare congenital cardiac abnormality. This approach facilitated our understanding of the patient's unique condition and enabled us to plan the surgical procedure with greater precision.Case presentationOur department received a 13-year-old female patient who presented with a pronounced heart murmur and a decrease in exercise capacity. Subsequent two-dimensional imaging revealed the presence of a criss-cross heart with double outlet right ventricle—an intricate and uncommon cardiac malformation that poses challenges for accurate visualization through conventional two-dimensional modalities. To address this challenge, we constructed and printed a three-dimensional model using computed tomography data, which enabled us to visualize and understand the complex intracardiac structures and plan surgical interventions with greater precision. Using this approach, we successfully performed a right ventricular double outlet repair, and the patient made a full recovery following the procedure.ConclusionThe criss-cross heart with double outlet right ventricle constitutes a complex and uncommon cardiac anomaly that poses considerable challenges in terms of diagnosis and surgical intervention. Employing three-dimensional modeling and printing represents a promising approach, given its potential to enhance the precision and comprehensiveness of the anatomical evaluation of the heart. As a result, this method holds significant promise in facilitating accurate diagnosis, meticulous surgical planning, and ultimately improving clinical outcomes for patients affected by this condition.
Weak degassing from remote Alaska volcanoes characterized with a new airborne imaging DOAS instrument and a suite of in situ sensors
Authors: Kern Christoph , Kelly Peter J. 
Published: May 2023

Gas emissions from volcanoes occur when volatile species exsolve from magmatic and hydrothermal systems and make their way to the surface. Measurements of emitted gases therefore provide insights into volcanic processes. On 16 July 2021, we made airborne measurements of weak gas plumes emitted from four remote Alaska volcanoes: Iliamna Volcano, Mount Douglas, Mount Martin, and Mount Mageik. Integrated into a small fixed-wing aircraft, a new Imaging Differential Optical Absorption Spectroscopy (DOAS) instrument was used to map the spatial extent of SO2 plumes as they drifted downwind. Contrary to conventional Mobile DOAS instruments, which provide only a single viewing direction, the Imaging DOAS simultaneously measures SO2 column density along 48 individual viewing directions oriented in a swath above or below the aircraft. Each of the individual measurements have a comparable precision and sensitivity to those obtained by conventional instruments. Together, they provide high resolution 2D imagery of the volcanic plumes and allow calculation of limited emission rate time series information. Although zenith-facing DOAS measurements achieve greater accuracy and are performed here, the application of the Imaging DOAS in a nadir-facing setup is also discussed and compared to satellite observations made in similar geometries. Also onboard the aircraft, a suite of electrochemical and optical sensors measured the relative abundances of the six major volcanic volatile species H2O, CO2, SO2, H2S, HCl, and HF as the aircraft passed through the plumes. Mean SO2 emission rates of 90 ± 10, 20 ± 3, and 13 ± 3 t/d were measured at Iliamna Volcano, Mount Douglas, and Mount Martin, respectively. SO2 emissions were below the DOAS detection limit at Mount Mageik but CO2 and H2S could be measured with the in situ sensors. The information gleaned from these measurements was used to assess and compare activity at these volcanoes, all of which were found to be in a state of background degassing but whose emissions pointed to different source conditions ranging from mixed magmatic-hydrothermal to purely hydrothermal in character. Additional measurements at Mount Spurr, Redoubt Volcano, and Augustine Volcano failed to detect the very weak gas concentrations downwind of these persistently degassing vents.
Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials
Authors: Ren Yu , Sun Shuang , Su Yongwei , Ying Chenfei , Luo Hua 
Published: May 2023

ObjectiveDiabetes mellitus is a worldwide health problem, and it remains unclarified whether fruit is beneficial in glycemic control. This study aimed to analyze evidence from randomized controlled trials evaluating the effect of fruit consumption on glucose control.MethodsWe searched the PubMed, EMBASE, Ovid, Web of Science, and Cochrane Central Register of Controlled Trials databases from the respective database inception dates to December 30, 2022, to identify randomized controlled trials that evaluated the effects of fruit consumption on glucose control. Two researchers independently screened the studies in accordance with the inclusion and exclusion criteria, and performed the literature quality evaluation and data extraction. RevMan 5.4 software was used to perform the data analysis.ResultsNineteen randomized controlled trials with 888 participants were included. Fruit consumption significantly decreased the fasting blood glucose concentration (MD -8.38, 95% CI -12.34 to -4.43), but it showed no significant difference in the glycosylated hemoglobin (MD -0.17, 95% CI -0.51 to 0.17). Subgroup analyses further suggested that the consumption of both fresh and dried fruit decreased the fasting blood glucose concentration.ConclusionsIncreasing the fruit intake reduced fasting blood glucose concentration. Therefore, we recommend that patients with diabetes eat more fruits while ensuring that their total energy intake remains unchanged.
Does phosphogypsum addition affect phosphate rock dissolution in acid soils?
Authors: Bouray Moussa , Moir Jim , El Mejahed Khalil , Choukr-Allah Redouane , El Gharous Mohamed 
Published: May 2023

The direct application of phosphate rock (PR) has been found suitable for acidic soils. Still, efforts are needed to improve its reactivity to match grassland P demand. This research aimed to investigate changes in the dissolution of two Moroccan sedimentary PRs (Ben Guerir and Khouribga) in response to four rates of phosphogypsum (PG)—a by-product of the phosphate fertilizer industry. We conducted a 60-day incubation study using two acid soils from New Zealand. The soils were treated with PRs at 100 mgP kg−1 of soil either alone or combined with PG, which was applied at 0, 1, 3 and 9 t ha−1 (approximately the equivalent of 0, 0.9, 2.7, and 8.1 g of PG kg−1 of soil, respectively). The dissolution rates were determined from the differences in residual calcium (Ca) extracted with 1 M HCl. Soil pH, Olsen P, exchangeable aluminium (Al) and Ca and Ca saturation were analyzed at the end of the experiment. Phosphate rocks and PG’s physicochemical properties were characterized. Phosphogypsum addition increased Olsen P by 34% and 59% at 9 t ha−1 compared to 0 t ha−1 in Molesworth and Lindis Peaks soils, respectively. However, PG did not affect the dissolution of PRs in the different of soil types. Khouribga PR was more reactive than Ben Guerir PR, especially in the Molesworth soil where soil pH and base saturation were lower and P retention was higher compared to Lindis Peaks soil. Particle size distribution was the key factor that contributed to the observed greater reactivity of the Khouribga PR. Both PRs showed dissolution rates &gt;50%, suggesting their suitability for direct application on acid soils. Being an important source of sulphur and some P, PG if combined with PR, can promote and complement PR’s direct use as fertilizer on acid soils. Moreover, the development of new fertilizer products by combining these two materials should be encouraged.
Racial/ethnic and socioeconomic disparities in COVID-19 infections among working-age women with precancerous cervical lesion in Louisiana: analysis of more than two years of COVID-19 data
Authors: Hsieh Mei-Chin , Lefante Christina , Straif-Bourgeois Susanne , Yi Yong , Gomez Natalie , Shrestha Pratibha , Chen Vivien W. , Wu Xiao-Cheng 
Published: May 2023

BackgroundPrecancerous cervical lesion (PCL) is common in working-age and minority women. In Louisiana, 98% of PCL cases were diagnosed at age 18–65 with over 90% of them being human papillomavirus (HPV)-related. PCL women represent those who may be immunocompromised from the precancerous condition and thus more vulnerable to SARS-CoV-2. Most studies evaluating racial disparities for COVID-19 infection have only used data prior to vaccine availability. This study assessed disparities by race/ethnicity and socioeconomic status (SES) in COVID-19 infections among working-age PCL women for pre- and post-COVID-19 vaccine availability.MethodsLouisiana women aged 18–65 with PCL diagnosed in 2009–2021 were linked with the Louisiana statewide COVID-19 database to identify those with positive COVID-19 test. Race/ethnicity was categorized as non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, and others. The census tract SES quintiles were created based on American Community Survey estimates. Logistic regression was employed to assess the racial/ethnic and SES differences in COVID-19 infections.ResultsOf 14,669 eligible PCL women, 30% were tested COVID-19 positive. NHB had the highest percentage of COVID-19 infection (34.6%), followed by NHW (27.7%). The infection percentage was inversely proportional to SES, with 32.9% for women having the lowest SES and 26.8% for those with the highest SES. NHB women and those with lower SES had higher COVID-19 infection than their counterparts with an aOR of 1.37 (95% CI 1.25–1.49) and 1.21 (95% CI 1.07–1.37), respectively. In the pre-vaccine period, NHB and Hispanic women had higher odds of infection than NHW women. However, after the vaccine was implemented, the significant racial/ethnic and SES differences in COVID-19 infections still existed in PCL women residing in non-Greater New Orleans area.ConclusionsThere are substantial variations in racial/ethnic and SES disparities in COVID-19 infections among working-age women with PCL, even after vaccine implementation. It is imperative to provide public health interventions and resources to reduce this unequal burden for this vulnerable population.
Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD
Authors: Li Yi , Yang Ying , Guo Tingting , Weng Chengxin , Yang Yongfeng , Wang Zhoufeng , Zhang Li , Li Weimin 
Published: May 2023

BackgroundDespite an increasing understanding of chronic obstructive pulmonary disease (COPD) pathogenesis, the mechanisms of diverse cell populations in the human lung remain unknown. Using single-cell RNA sequencing (scRNA-Seq), we can reveal changes within individual cell populations in COPD that are important for disease pathogenesis and characteristics. MethodsWe performed scRNA-Seq on lung tissue obtained from donors with non-COPD and mild-to-moderate COPD to identify disease-related genes within different cell types. We testified the findings using qRT−PCR, immunohistochemistry, immunofluorescence and Western blotting from 25 additional subjects and RAW 264.7 macrophages. Targeting ferroptosis with the ferroptosis inhibitor ferrostatin-1, iron chelator deferoxamine or HO-1 inhibitor zinc protoporphyrin was administered in the experimental cigarette smoke COPD mouse model.ResultsWe identified two populations of alveolar macrophages (AMs) in the human lung that were dysregulated in COPD patients. We discovered that M2-like AMs modulate susceptibility to ferroptosis by disrupting lipid and iron homeostasis both in vivo and in vitro. The discrepancy in sensitivity to ferroptosis can be determined and regulated by HO-1. In contrast, M1-like AMs showed the ability to attenuate oxidative stress and exert resistance to ferroptosis. In addition, the expression of genes within M2-like AMs is also involved in defects in phagocytosis and lysosome distortion. This ferroptotic phenotype was ameliorated by antiferroptotic compounds, iron chelators and HO-1 inhibitors. During COPD, the accumulation of lipid peroxidation drives ferroptosis-sensitive M2-like AMs, while M1-like AMs show characteristics of ferroptosis resistance. Ferroptotic M2 AMs lose their anti-inflammatory and repair functions but provoke inflammatory responses, resulting in consistent inflammation and tissue damage in the presence of M1 AMs in COPD. ConclusionAppropriate interventions in ferroptosis can reduce the occurrence of infections and acute onset, and delay the COPD process.
The molecular mechanism of Gorham syndrome: an update
Authors: Xiang Juqin , Zhong Weiyang 
Published: May 2023

Gorham syndrome, also known as “vanishing osteopathy” and “invasive hemangiomatosis,” is a rare clinical syndrome whose etiology is unknown and can invade the whole-body skeleton. At present, more than 300 cases have been reported at home and abroad, usually manifesting as spontaneous chronic osteolysis with no periosteal reaction at the lysis site and occult onset, often with fractures, scoliosis, chylothorax, etc. When waiting for medical treatment, the condition is serious, and the prognosis is poor. At present, there is no effective treatment. The main pathological manifestations of Gorham syndrome are the non-neoplastic abnormal proliferation of lymphatic vessels or blood vessels and osteolysis caused by osteoclast proliferation or increased activity. At present, there is no unified conclusion regarding Gorham syndrome’s pathogenesis. This paper starts with the two most studied osteolysis methods at present, osteoclast osteolysis and osteolysis caused by vascular and lymphatic proliferation and summarizes the corresponding most possible molecular mechanisms in recent years to provide more ideas for Gorham syndrome treatment.
Epigenetically altered macrophages promote development of diabetes-associated atherosclerosis
Authors: Huang Dong , Gao Wei , Zhong Xin , Wu Hongxian , Zhou You , Ma Yuanji , Qian Juying , Ge Junbo 
Published: May 2023

BackgroundAtherosclerosis (AS) risk is elevated in diabetic patients, but the underlying mechanism such as involvement of epigenetic control of foam macrophages remains unclear. We have previously shown the importance of immune regulation on endothelial cells to AS development in diabetes. In this study, we examined the hypothesis that diabetes may promote AS through modification of the epigenetic status of macrophages.MethodsWe employed the Laser Capture Microdissection (LCM) method to evaluate the expression levels of key epigenetic regulators in both endothelial cells and macrophages at the AS lesions of patients. We then assessed the correlation between the significantly altered epigenetic regulator and serum levels of low-density Lipoprotein (LDL), triglycerides (TRIG) and high-density Lipoprotein (HDL) in patients. In vitro, the effects of high glucose on glucose utilization, lactate production, succinate levels, oxygen consumption and polarization in either undifferentiated or differentiated bone marrow-derived macrophages (BMDMs) were analyzed. The effects of depleting this significantly altered epigenetic regulator in macrophages on AS development were assessed in AS-prone diabetic mice.ResultsHistone deacetylase 3 (HDAC3) was identified as the most significantly altered epigenetic regulator in macrophages from the AS lesions in human diabetic patients. The levels of HDAC3 positively correlated with high serum LDL and TRIG, as well as low serum HDL. High glucose significantly increased glucose utilization, lactate production, succinate levels and oxygen consumption in cultured macrophages, and induced proinflammatory M1-like polarization. Macrophage depletion of HDAC3 significantly attenuated AS severity in AS-prone diabetic mice.ConclusionEpigenetically altered macrophages promote development of diabetes-associated AS, which could be prevented through HDAC3 depletion.
Optical observations and spatio-temporal projections of gelatinous zooplankton in the Fram Strait, a gateway to a changing Arctic Ocean
Authors: Pantiukhin Dmitrii , Verhaegen Gerlien , Kraan Casper , Jerosch Kerstin , Neitzel Philipp , Hoving Henk-Jan T. , Havermans Charlotte 
Published: May 2023

Global warming causes profound environmental shifts in the Arctic Ocean, altering the composition and structure of communities. In the Fram Strait, a transitional zone between the North-Atlantic and Arctic Ocean, climate change effects are particularly pronounced and accelerated due to an increased inflow of warm Atlantic water. Gelatinous zooplankton are known as key predators, consuming a great variety of prey and playing an important role in marine ecosystems. Insufficient knowledge of how gelatinous zooplankton are affected by environmental change has resulted in a notable gap in the understanding of the future state of Arctic ecosystems. We analyzed the diversity and abundance of gelatinous zooplankton down to 2600 m depth and established the first regional baseline dataset using optical observations obtained by the towed underwater camera system PELAGIOS (Pelagic In situ Observation System). Our data estimate the abundance of 20 taxa of gelatinous zooplankton. The most abundant taxa belong to the family of Rhopalonematidae, mainly consisting of Aglantha digitale and Sminthea arctica, and the suborder Physonectae. Using the observational data, we employed a joint species distribution modelling approach to better understand their distributional patterns. Variance partitioning over the explanatory variables showed that depth and temperature explained a substantial amount of variation for most of the taxa, suggesting that these parameters drive diversity and distribution. Spatial distribution modelling revealed that the highest abundance and diversity of jellyfish are expected in the marginal sea-ice zones. By coupling the model with climate scenarios of environmental changes, we were able to project potential changes in the spatial distribution and composition of gelatinous communities from 2020 to 2050 (during the summer season). The near-future projections confirmed that with further temperature increases, gelatinous zooplankton communities in the Fram Strait would become less diverse but more abundant. Among taxa of the Rhopalonematidae family, the abundance of Aglantha digitale in the entire water column would increase by 2%, while a loss of up to 60% is to be expected for Sminthea arctica by 2050. The combination of in situ observations and species distribution modelling shows promise as a tool for predicting gelatinous zooplankton community shifts in a changing ocean.
Iguratimod as an alternative therapy for systemic sclerosis and prevention of the occurrence of ischemic digital ulcer
Authors: Yan Qingran , Liu Bei , Wang Jieying , Yin Hanlin , Li Qianqian , Lu Liangjing 
Published: May 2023

ObjectivesThis study aimed to assess the effectiveness of iguratimod (IGU) as an alternative treatment for systemic sclerosis (SSc), especially in the prevention of ischemic digital ulcers (DUs).MethodsWe constructed two cohorts from the Renji SSc registry. In the first cohort, SSc patients receiving IGU were observed prospectively with effectiveness and safety. In the second cohort, we picked up all the DU patients with at least a 3-month follow-up to investigate the prevention of IGU on ischemic DU.ResultsFrom 2017 to 2021, 182 SSc patients were enrolled in our SSc registry. A total of 23 patients received IGU. With a median follow-up of 61 weeks (IQR: 15–82 weeks), the drug persistence was 13/23. In total, 91.3% of the patients (21/23) became free of deterioration in the last visit with IGU. Of note, 10 patients withdrew from the study due to the following reasons: two patients withdrew due to deterioration, three due to incompliance, and five due to mild-to-moderate side effects. All the patients with side effects recovered fully after stopping IGU. Of note, 11 patients had ischemic DU, and 8 out of 11 (72.7%) patients had no new occurrence of DU during the follow-up. In the second cohort of 31 DU patients receiving a combination of vasoactive agents with a median follow-up of 47 weeks (IQR, 16–107 weeks), IGU treatment was protective of new DU occurrence (adjusted risk ratio = 0.25; 95% CI, 0.05–0.94; adjusted odds ratio = 0.07; and 95% CI, 0.01–0.49).ConclusionOur study for the first time describes the potential of IGU possibly as an alternative treatment for SSc. To our surprise, this study provides a hint that IGU treatment can be used for the prevention of the occurrence of ischemic DU and merits further investigation.