bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gentherapien für Epilepsie: Klinische Studien sind auf dem
Weg
Authors: Müller Peter , Lerche Holger 
Published: January 2023

ZusammenfassungSeit über 10 Jahren wird an Gentherapien für die schwersten
Formen von Epilepsie geforscht, die bis jetzt therapieresistent sind. Nun
ergeben sich für fokale pharmakoresistente Epilepsien und für
das Dravet Syndrom Gentherapieansätze in ersten klinischen Studien. In
diesem Artikel beschreiben wir die Funktionsweise und Ziele dieser und weiterer
Gentherapien.
Retro-[4+2]/Intramolecular Diels–Alder Cascade Allows a Concise Total Synthesis of Lucidumone
Authors: de la Torre Aurélien , Huang Guanghao , Kouklovsky Cyrille 
Published: January 2023

AbstractLucidumone is a recently isolated meroterpenoid displaying interesting biological activity. This natural product possesses a complex structure, including a bicyclo[2.2.2]octane possessing 6 contiguous stereogenic centers. Herein, we discuss strategies to solve this synthetic challenge. In particular, we developed a new method for the inverse electron-demand Diels–Alder cycloaddition between 2-pyrones and acyclic enol ethers, as a mean to obtain a ‘masked’ cyclohexadiene. This method allowed an expeditious enantioselective synthesis of (+)-lucidumone through a retro-[4+2]/intramolecular Diels–Alder reaction cascade.1	Introduction2	Retrosynthetic Considerations on the Bicyclo[2.2.2]octane3	Development of a Methodology for Enantioselective IEDDA Cycloadditions4	Enantioselective Total Synthesis of (+)-Lucidumone5	Conclusion
Coronary Anastomosis In Stent—Useful to Do When No Other Alternative Is Given?
Authors: Balan Robert , Mogilansky Christian , Czesla Markus , Massoudy Parwis 
Published: January 2023

Abstract
Background Many patients being referred for coronary artery bypass grafting have a history of percutaneous coronary intervention (PCI).
Case Description In a patient after multiple PCI of the left anterior descending artery (LAD), repeated in-stent stenosis was diagnosed. The LAD being covered with stents to the periphery, no meaningful anastomosis with stent-free vessel was possible. After thorough discussion with the patient, the referring cardiologist, and our local heart team, an in-stent anastomosis was planned and created, that was found to be angiographically patent 21 months after surgery with the patient free from angina.
Conclusion Without any alternative treatment method given, our approach of in-stent anastomosis confers a good mid-term angiographic result.
Women’s online opinions are still not as influential as those of their male peers in buying decisions
Authors: Fan-Osuala Onochie 
Published: January 2023

AbstractAs we make progress towards gender parity in many spheres of life, an important question is whether people place as much value on women’s opinions as they do on men’s opinions, especially when making buying decisions. Using online product opinions (reviews)—an increasingly important source of information in buying decisions—as our context, we investigate whether women’s product opinions are as valuable as those of their male peers. Across three studies—one experimental and two using field data from online review platforms in the United States, we report evidence of implicit gender bias in evaluating online product opinions. In the experimental study, 216 participants (108 men, 108 women, mean age 40.6) participated in an online study where they evaluated reviews written by men and women across different product types. We find that, compared to men, women’s product opinions were rated as less helpful and were less likely to influence people’s buying decisions. For gender-typed products, that is, products highly associated with specific gender groups, men’s product opinions were rated higher than women’s in helpfulness and likelihood to influence buying decisions for male gender-typed products. However, there was no significant difference between men’s product opinions and women’s product opinions for female gender-typed products, indicating that women’s product opinions are not perceived as being more valuable than men’s opinion even for products typically associated with women. In the field data studies, we relied on the internet public’s helpfulness and usefulness votes on reviews contributed by both men and women across both search and experience goods to confirm the findings in the experimental study. We discuss some of the potential reasons and implications of our findings.
In situ x-ray absorption investigations of a heterogenized molecular catalyst and its interaction with a carbon nanotube support
Authors: Zoric Marija R. , Chan Thomas , Musgrave Charles B. , Goddard William A. , Kubiak Clifford P. , Cordones Amy A. 
Published: January 2023

A highly active heterogenized molecular CO2 reduction catalyst on a conductive carbon support is investigated to identify if its improved catalytic activity can be attributed to strong electronic interactions between catalyst and support. The molecular structure and electronic character of a [Re+1(tBu-bpy)(CO)3Cl] (tBu-bpy = 4,4′-tert-butyl-2,2′-bipyridine) catalyst deposited on multiwalled carbon nanotubes are characterized using Re L3-edge x-ray absorption spectroscopy under electrochemical conditions and compared to the homogeneous catalyst. The Re oxidation state is characterized from the near-edge absorption region, while structural changes of the catalyst are assessed from the extended x-ray absorption fine structure under reducing conditions. Chloride ligand dissociation and a Re-centered reduction are both observed under applied reducing potential. The results confirm weak coupling of [Re(tBu-bpy)(CO)3Cl] with the support, since the supported catalyst exhibits the same oxidation changes as the homogeneous case. However, these results do not preclude strong interactions between a reduced catalyst intermediate and the support, preliminarily investigated here using quantum mechanical calculations. Thus, our results suggest that complicated linkage schemes and strong electronic interactions with the initial catalyst species are not required to improve the activity of heterogenized molecular catalysts.
Classification and characterization of coexisting defects from magnetic flux leakage data using deep learning method
Authors: Piao Guanyu , Ling Jiatong , Li Jiaoyang 
Published: January 2023

Ferromagnetic materials are widely used in infrastructure, such as steam generators, storage tanks, and gas pipelines. During their service time, ferromagnetic materials are subject to deterioration and defects are prone to generate which could damage infrastructures and cause catastrophic accidents. Magnetic flux leakage (MFL) is one of the widely used nondestructive evaluation (NDE) methods to detect and characterize defects in ferromagnetic materials to ensure infrastructure safety. However, many research works have been carried out on the modeling, classification, and characterization of a single defect, while the scenario of coexisting defects is ignored. In practical field, the coexistence of surface and subsurface defects within an overlapping area can cause much earlier than expected deterioration or even penetration, the result of which is more damaging. Here, we propose a convolutional neural network (CNN) based deep learning method to differentiate between single defect and coexisting defects scenarios and estimate the defect sizes including length, width, and depth. Finite-element-method (FEM) simulation models are developed to investigate the effect of coexisting defects on the measured MFL data. The models with different defect parameters are calculated to generate 354 MFL data for the training and testing of deep learning method. The experimental results show that the classification accuracy of deep learning method is over 94% and higher than the traditional machine learning methods, and the defect size estimation errors are within 0.97 mm, 0.59 mm, and 3.67% of wall thickness, respectively, which are validated to be a good classification and characterization tool for the coexisting defects scenario.
Multi-directional extremely-low-frequency electromagnetic ocean wave energy harvester based on improved double pendulum structure
Authors: Li Yuquan , Qiu Jing , Lan Tian , Song Hongrui 
Published: January 2023

The study of ocean wave energy harvesting technology is of great importance in the field of distributed sensor energy supply. Aiming at the problems of insufficient output power, single direction of collecting vibration, restricted working frequency band and complex structure of traditional ocean wave energy harvesters of marine network nodes, a multi-directional extremely-low-frequency electromagnetic ocean wave energy harvester based on improved double pendulum structure is designed. The effect of different component parameters of the energy harvester on the output electrical performance is analyzed by simulation software and a constructed vibration test rig, and the relationship between output voltage and motion state is explored. After optimizing the structure, the ocean wave energy harvester has a minimum response frequency of about 0.25 Hz at a vertical wave height of 0.6 m and a minimum response flow speed of about 0.3 m/s in the horizontal direction. The peak output power is about 150 mW when the wave height is 0.6 m at a frequency of 1 Hz and about 110 mW when the horizontal speed is 0.9 m/s. Experimental results show that the energy harvester can better capture ocean wave energy and provide power for night lights and even IoT devices.
Urban billabong restoration benefits from Traditional Owner involvement and regular flooding
Authors: Greet Joe , Lankri Rephael , Gaskill Sarah , Fischer Sarah , Freedman Delta Lucille , Preston Tiana 
Published: January 2023

Context Floodplain wetlands (e.g. billabongs) in urban environments have significant ecological and cultural value, yet are often highly degraded. Impacts such as reduced flooding and weed invasion continue to threaten these critical ecosystems. Both ecological and Indigenous people’s knowledge are important for urban billabong restoration. Aims Our project aimed to (1) assess the response of billabong vegetation to flooding, and (2) increase the role of local Traditional Owners in billabong management. Methods Over 3 years, a team of wetland ecologists and local Wurundjeri Woi Wurrung Narrap (‘Country’) Rangers surveyed responses of understorey vegetation and the condition and flowering of remnant river red gums (Eucalyptus camaldulensis) to flooding across seven degraded billabongs adjacent to the Birrarung (Yarra River) in Melbourne, Australia. Knowledge sharing during ‘On Country’ days guided restoration targets and management direction. Key results Regular (at least 2 in 3 years) and longer-duration (up to 8 months) flooding promoted native wetland plants, supressed weeds, and improved the condition and reproductive output of river red gums. Monitoring by Indigenous Rangers facilitated the cultural practice of caring for Country. Conclusions Regular flooding and Traditional Owner involvement promotes billabong health. Implications Collaborative research and knowledge sharing with Traditional Owners advances wetland restoration practice and improves care of Country.
Data-driven predictions of the time remaining until critical global warming thresholds are reached
Authors: Diffenbaugh Noah S. , Barnes Elizabeth A. 
Published: January 2023

Leveraging artificial neural networks (ANNs) trained on climate model output, we use the spatial pattern of historical temperature observations to predict the time until critical global warming thresholds are reached. Although no observations are used during the training, validation, or testing, the ANNs accurately predict the timing of historical global warming from maps of historical annual temperature. The central estimate for the 1.5 °C global warming threshold is between 2033 and 2035, including a ±1σ range of 2028 to 2039 in the Intermediate (SSP2-4.5) climate forcing scenario, consistent with previous assessments. However, our data-driven approach also suggests a substantial probability of exceeding the 2 °C threshold even in the Low (SSP1-2.6) climate forcing scenario. While there are limitations to our approach, our results suggest a higher likelihood of reaching 2 °C in the Low scenario than indicated in some previous assessments—though the possibility that 2 °C could be avoided is not ruled out. Explainable AI methods reveal that the ANNs focus on particular geographic regions to predict the time until the global threshold is reached. Our framework provides a unique, data-driven approach for quantifying the signal of climate change in historical observations and for constraining the uncertainty in climate model projections. Given the substantial existing evidence of accelerating risks to natural and human systems at 1.5 °C and 2 °C, our results provide further evidence for high-impact climate change over the next three decades.
An endoscopically compatible fast-gelation powder forms Janus-adhesive hydrogel barrier to prevent postoperative adhesions
Authors: Jia Yuanbo , Feng Jinteng , Feng Zhe , Liu Jingyi , Yang Yanshen , Li Xiaokang , Lei Meng , Guo Hui , Wei Zhao , Lv Yi , Xu Feng 
Published: January 2023

Postoperative adhesions occur widely in various tissues, bringing the risk of secondary surgery and increased medical burden. Hydrogel barriers with Janus-adhesive ability can achieve physical isolation of adjacent tissues and are therefore considered an ideal solution. However, integrating endoscopic delivery convenience and viscoelastic Janus hydrogel formation remains a great challenge. Here, we present a report of the in situ formation of Janus-adhesive hydrogel barrier using a sprayable fast-Janus-gelation (FJG) powder. We first methacrylate the polysaccharide macromolecules to break the intermolecular hydrogen bonds and impart the ability of rapid hydration. FJG powder can rapidly absorb interfacial water and crosslink through borate ester bonds, forming a toughly adhesive viscoelastic hydrogel. The Janus barrier can be simply formed by further hydrating the upper powder with cationic solution. We construct rat models to demonstrate the antiadhesions efficiency of viscoelastic FJG hydrogels in organs with different motion modalities (e.g., intestine, heart, liver). We also developed a low-cost delivery device with a standardized surgical procedure and further validated the feasibility and effectiveness of FJG powder in minimally invasive surgery using a preclinical translational porcine model. Considering the advantages in terms of therapeutic efficacy, clinical convenience, and commercialization, our results reveal the great potential of Janus-gelation powder materials as a next-generation antiadhesions barrier.
Three Cases of Plagiarism?
Authors: Zack Liesbeth 
Published: January 2023

Summary
This article discusses four 19th-century textbooks for teaching Egyptian Arabic to foreigners: Nolden’s Vocabulaire français arabe (1844), Zenker’s Vocabulaire phraséologique français-arabe (1854, published under the pseudonym Barthélémy), Sacroug’s The Egyptian Travelling Interpreter (1874) and De Vaujany & Radouan’s Vocabulaire français-arabe (1887). These books display remarkable similarities. They contain, among other subjects, a vocabulary, a grammar, useful Arabic phrases and Egyptian weights and measures. Zenker, Sacroug and De Vaujany & Radouan copied extensively from Nolden’s book without referring to the original source. However, these three textbooks are not exact copies (or, in the case of Sacroug, not an exact translation) of Nolden’s book: although the authors took Nolden’s Vocabulaire as their basis, they also considerably reworked it and added extra materials. In this paper, the contents of the four textbooks are compared in order to determine how the authors treated Nolden’s work, what they added and how they improved it.
Communication strategies, personal adjustments, and need for recovery in employees with hearing loss who receive a communication group-training
Authors: Hoek-Snieders van der Hanneke E. M. , Boymans Monique , Dreschler Wouter A. 
Published: January 2023

Purpose
Communication group-trainings are part of current aural rehabilitation practices, but their effect has not yet been investigated systematically in working adults. The purpose of this study was to describe the communication strategies (CS), personal adjustments (PA) and need for recovery (NFR) of employees with hearing loss before and directly after a communication group-training.

Methods
Nine employees were included at two audiological centres that provided a different group-training. Two online questionnaires were completed, at baseline and after completing the training.

Results
Most employees used more adequate CS after the group-training, but there seems to be a difference between the improvement in PA between the centres. No trends towards a decrease in NFR were observed.

Conclusion
It is still challenging to reduce the work difficulties that are encountered by employees with hearing loss. The inter-centre differences point out a need for standardization. Suggestions for improvements are provided and should be further investigated in a larger population.
Big bang singularity resolution in quantum cosmology
Authors: Thébault Karim P Y 
Published: January 2023

Abstract
We evaluate the physical viability and logical strength of an array of putative criteria for big bang singularity resolution in quantum cosmology. Based on this analysis, we propose a mutually consistent set of constitutive conditions, which we argue should be taken to jointly define ‘global dynamics’ and ‘local curvature’ big bang singularity resolution in this context. Whilst the present article will focus exclusively on evaluating resolution criteria for big bang singularities in the context of finite dimensional models of quantum cosmology, it is also hoped that the core features of our analysis will be extendible to a more general analysis of criteria for quantum singularity resolution in cosmology and black hole physics.
Energetics and Efimov states of three interacting bosons and mass-imbalanced fermions in a three-dimensional spherical harmonic trap
Authors: Kerin A D , Martin A M 
Published: January 2023

Abstract
We consider a system of three particles, either three identical bosons or two identical fermions plus an impurity, within a three-dimensional isotropic trap interacting via a contact interaction. Using two approaches, one using an infinite sum of basis states for the wavefunction and the other a closed form wavefunction, we calculate the allowable energy eigenstates of the system as a function of the interaction strength, including the strongly and weakly interacting limits. For the fermionic case this is done while maintaining generality regarding particle masses. We find that the two methods of calculating the spectrum are in excellent agreement in the strongly interacting limit. However the infinite sum approach is unable to uniquely specify the energy of Efimov states, but in the strongly interacting limit there is, to a high degree of accuracy, a correspondence between the three-body parameter required by the boundary condition of the closed form approach and the summation truncation order required by the summation approach. This specification of the energies and wavefunctions forms the basis with which thermodynamic variables such as the virial coefficients or Tan contacts, or dynamic phenomena like quench dynamics can be calculated.
Accumulation effect of active species in atmospheric-pressure plasma jet driven by nanosecond high-voltage pulses with MHz pulse repetition rate
Authors: Huang Bangdou , Zhang Cheng , Zhang Chuansheng , Shao Tao 
Published: January 2023

Abstract
With respect to successful applications of pulsed power in gas discharges, the enhanced generation of desired active species and control of plasma parameters as required are always decisive issues. In this study, a bipolar nanosecond high-voltage pulse generator with a maximum pulse repetition rate (PRR) of up to 1 MHz (i.e. a minimum pulse interval of 1 µs) in burst mode is developed, based on the principle of full-bridge converter and pulse transformer. This pulse source is used to generate an atmospheric-pressure plasma jet in Ar + 1%CH4 gas flow, and the influence of pulse intervals (from 1–10 µs) is explored. It is found that the pulse interval can strongly modulate the active species, i.e. a short pulse interval enhances the generation of C2 radial and H atom due to the accumulation effect, when the pulse interval is comparable with their lifetime, while it slightly suppresses the generation of Ar excited states and the energy fraction into electronic excitation. Reduced pulse intervals also prominently increase the energy fraction of vibrational excitation. This study demonstrates how the PRR effectively modulates active species and energy branching and enhances the generation of certain active species in atmospheric-pressure plasma driven by pulsed power.
Femtosecond infra-red laser carbonization and ablation of polyimide for fabrication of Kirigami inspired strain sensor
Authors: Biswas Ratul Kumar , Farid Nazar , Bhatt Bharat Bhushan , Gupta Dipti , O’Connor Gerard M , Scully Patricia 
Published: January 2023

Abstract
Microfabrication of polyimide (PI) with femtosecond laser of wavelength 1030 nm is studied in two process conditions. Firstly, the low power-low scan speed regime is investigated for laser carbonization producing piezoresistive laser induced graphene (LIG). The heat accumulation model is modelled to find the temporal evolution of temperature at the laser focus for a single laser scan. Secondly, the high power-high scan speed regime is studied for laser ablation where clean ablation was observed due to multiphoton absorption. To demonstrate the application of this process, a two-dimensional (2D) LIG based strain sensor is drawn on a Kapton PI sheet using laser carbonization and transformed into a three-dimensional (3D) conformal sensor by cutting into a Kirigami design using laser ablation. The strain in the sensor is calculated from finite element analysis and the gauge factor is 88.58 ± 0.16. This laser process enables the transformation of any 2D PI sheet into a 3D conformal sensor using femtosecond laser, which is useful for wearable sensors and health-monitoring applications. The fabricated sensor is demonstrated used on a knee-joint to monitor real-time tracking of bending and twisting knee movements.
Flow control around a pitching oscillation circular cylinder using a dielectric barrier discharge plasma actuator
Authors: Uemura Takuma , Komuro Atsushi , Ono Ryo 
Published: January 2023

Abstract
This paper discusses flow control around a stationary and pitching oscillation circular cylinder using a dielectric barrier discharge plasma actuator (PA). The pressure on the cylinder surface was measured to determine the lift and drag forces on the cylinder, and the differences between these values were investigated with and without the PA actuations. The results indicated that the time-averaged lift force increased by up to 140% for the 180° rotating cylinder. Additionally, the effect of the PA on the lift-hysteresis curve of the pitching cylinder were evaluated based on the temporal variation in the surface pressure. Moreover, to investigate the effect of the PA on the flow field, smoke wire and LED-PIV methods were used to visualize the flow around the cylinder. The results showed that PA promotes the mixing between the freestream and separated flow which makes the separated shear layer thicker for both stationary and a pitching oscillating cylinder. For the pitching oscillating cylinder, the flow fields modified by PA actuation are different depending on the direction of the rotation of the cylinder. These results indicate that PA enhances the circulation of the flow around the cylinder.