bluuebunny/crossref_metadata_2025_split huggingface dataset:
A DisCrit Analysis of Quality in Early Childhood: Toward Pedagogies of Wholeness, Access, and Interdependence
Authors: Beneke Margaret R. , Love Hailey R. 
Published: December 2022

Background: In U.S. contexts, the language of “quality” early childhood education is widely invoked to evaluate the “goodness” of teaching and learning and is often leveraged in attempts to ameliorate inequities. Likewise, efforts to define and achieve generalizable conceptualizations of early childhood quality often guide what takes place in teacher education. Though objections to quality reform efforts and the ways they uphold white supremacy have been extensively discussed, less work has explicitly examined how ableism intersects with racism in the ways quality is defined and applied in early childhood. Purpose: The purpose of this conceptual article is to extend prior critiques of quality to critically examine intersections of racism and ableism in the definitions, measurements, and enactments of quality early childhood teaching and learning. We bring disability critical race theory (DisCrit; Annamma et al., 2013) into conversation with literature on quality in early childhood to examine how traditional notions of early childhood quality position and affect multiply-marginalized children, families, and teachers. We emphasize how dominant notions of early childhood quality are reinforced and can be disrupted in teacher preparation. Interpretive Analysis: We utilize DisCrit’s seven interrelated tenets to analyze how ableism and racism mutually reinforce notions of early childhood quality by: (1) predefining universal goals for teaching and learning; (2) reducing the complexity of teaching and learning; and (3) discarding the wisdom of multiply-marginalized children, families, and teachers. Each of these technocratic processes rely on one another (and at times, overlap) to uphold whiteness and ableism in both early childhood practice and teacher education; exposing them allows us to imagine alternate ways of conceptualizing and enacting meaningful early education. Through DisCrit praxis, we offer an alternative language of evaluation that centers multiply-marginalized young children, families, and teachers using pedagogies of wholeness, access, and interdependence. Conclusions: At the nexus of ableism and racism, standardized notions of early childhood quality create myriad forms of harm for multiply-marginalized children, families, and teachers. Although the language of quality pervades the field, we know it is not the only way. We implore teacher educators to support teacher candidates in developing a DisCrit praxis, as we engage in such processes of reflection and action ourselves. When teaching and learning are rooted in principles of wholeness, access, and interdependence, we put multiply-marginalized communities at the heart of our work, reclaiming and enacting meaningful pedagogies in early childhood.
Preferences for cardiovascular and pulmonary rehabilitation care: A discrete choice experiment among patients in Lebanon
Authors: Farah Rebecca , Groot Wim , Pavlova Milena 
Published: December 2022

Objective Patient preferences are important in designing optimal rehabilitation care. The aim of this study is to assess preferences for rehabilitation care among two groups of respondents. Design An online discrete choice experiment survey was carried out. Setting We use data for Lebanon, a country where rehabilitation care is still underdeveloped. Participants Patients who have undergone or are currently undergoing rehabilitation treatment (users) and those who have not (yet) used rehabilitation care (non-users). Intervention Patients were asked to repeatedly choose between two hypothetical rehabilitation care packages with seven different attributes: attitude of the staff, travel time to clinic, out-of-pocket costs, medical equipment, rehabilitation plan, additional lifestyle education session, and support during rehabilitation care. Main measures Preference heterogeneity among patients with different characteristics was investigated using random effect binary logistic regression (software package Stata 15). Results In total, 126 respondents completed the survey. The most preferred attribute was an informal and friendly attitude of the staff followed by modern medical equipment, additional lifestyle education session via eHealth, and support during the rehabilitation program via phone call or SMS. Respondents were less in favor of going to the rehabilitation clinic and paying additional out-of-pocket costs for the rehabilitation treatment. This rank order was similar between users and non-users. Conclusion Preferences of patients regarding the type of program chosen (eHealth or at clinical-based) need to be included in future rehabilitation programs. Improving patient experience with rehabilitation programs by giving the best care based on a patient-centered approach is essential.
Effect of radiofrequency coil and primary magnetic field on radiolucent composite plates
Authors: Gawande Atul S , Mukka Ramachanra Shreyas , Kamyab Hesam , Trung Nguyen-Thoi , Kattimani Subhaschandra 
Published: December 2022

Magnetic Resonance Imaging (MRI) systems need a material compatible with the imaging technique with lesser attenuation and provide accurate images without distortion. Carbon fibers are the best-suited materials for x-ray applications because of their radiolucent properties and reduced attenuation characteristics. However, carbon fiber produces images with distortion in the MRI system by absorbing electromagnetic energy because of its conductive nature. In the present study, five different fiber-reinforced radiolucent composite plates are analyzed to predict their suitability for a radio frequency coil and the effect of a primary magnetic field of 1.5 T and 3.0 T on mechanical responses. Simulation models are built to explore the impact of electromagnetic waves and birdcage coil configurations on composite material and quantify the temperature changes caused due to energy absorption. A multiphysics coupling simulation is being used to understand the effect of stacking sequence, ply orientation, and boundary conditions on the response of composite plates under an electro-magneto-mechanical environment.
Improved coyote optimization algorithm for parameter estimation of lithium-ion batteries
Authors: Hao Yuefei , Ding Jie , Huang Shimeng , Xiao Min 
Published: December 2022

This paper studies the parameter estimation of fractional order equivalent circuit model of lithium-ion batteries. Since intelligent optimization algorithms can achieve parameters with high accuracy by transforming the parameter estimation into optimization problem, coyote optimization algorithm is taken in this paper by modifying two key steps so as to improve the accuracy and convergence speed. Firstly, tent chaotic map is introduced to avoid falling into local optimum and enhance population diversity. Secondly, dual strategy learning is employed to improve the searching ability, accuracy and convergence speed. Non-parametric statistical significance is tested by 6 benchmark functions with the comparison of other 5 optimization algorithms. Furthermore, the proposed algorithm is applied to identify the fractional order model of the Samsung ICR18650 (2600 mAh) and compared with conventional coyote optimization algorithm and particle swarm algorithm, which declared the excellence in identification accuracy.
Zn[B3O4(OH)3] composites fabrication based on PVC pipes scrap via comparing melt mixing and casting procedures under the effect of electron beam irradiation
Authors: Fathy ES , Elnaggar Mona Y , Raslan Heba A , Hassan Medhat M 
Published: December 2022

In several works, scientific researchers targeted the development of polymeric materials with good mechanical and thermal properties and resist heat and fire propagation. In a new approach, this article goals to the usage of waste polyvinyl chloride (WPVC) based polymer composites derived from PVC pipes scrap filled with fixed percent of zinc borate particles (ZnB), which were prepared via two different techniques named melt mixing WPVC/ZnB (M) and casting WPVC/ZnB (C). The fabricated composites by the two methods were irradiated in an electron beam accelerator (EB) at 30 kGy. A comparative study of the thermal and mechanical properties based on stress-strain curves, tensile strength (TS), elongation at break (E %), and tear strength were evaluated. Furthermore, the rate of heat burning (%) for the two methods has been performed. Moreover, differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Infrared spectroscopy analysis (FTIR), X-ray diffraction (XRD), and the activation energy (Ea) calculation of the prepared samples have been considered. The observed improvements in the mechanical, thermal, and flammability behavior of WPVC were succeeded by incorporating ZnB particles. The irradiated WPVC loaded with zinc borate presented a superior flame propagation fraction when matched with their corresponding unirradiated composites. Also, WPVC composite films prepared via the melt mixing method reveal more excellent properties than those equipped by the casting process for the most investigated factors.
The Middle-Out Perspective: an approach to formalise ‘normal practice’ in public health advocacy
Authors: Mindell JS , Parag Y , Bartington SE , Stoll L , Barlow J , Janda KB 
Published: December 2022

Aims: The middle-out perspective (MOP) provides a lens to examine how actors positioned between government (top) and individuals (bottom) act to promote broader societal changes from the middle-out (rather than the top-down or bottom-up). The MOP has been used in recent years in the fields of energy, climate change, and development studies. We argue that public health practitioners involved with advocacy activities and creating alliances to amplify health promotion actions will be familiar with the general MOP concept if not the formal name. The article aims to demonstrate this argument. Methods: This article introduces the MOP conceptual framework and customises it for a public health audience by positioning it among existing concepts and theories for actions within public health. Using two UK case studies (increasing signalised crossing times for pedestrians and the campaign for smoke-free legislation), we illustrate who middle actors are and what they can do to result in better public health outcomes. Results: These case studies show that involving a wider range of middle actors, including those not traditionally involved in improving the public’s health, can broaden the range and reach of organisations and individuals involving in advocating for public health measures. They also demonstrate that middle actors are not neutral. They can be recruited to improve public health outcomes, but they may also be exploited by commercial interests to block healthy policies or even promote a health-diminishing agenda. Conclusion: Using the MOP as a formal approach can help public health organisations and practitioners consider potential ‘allies’ from outside traditional health-related bodies or professions. Formal mapping can expand the range of who are considered potential middle actors for a particular public health issue. By applying the MOP, public health organisations and staff can enlist the additional leverage that is brought to bear by involving additional middle actors in improving the public’s health.
Biomechanical Comparison of Unilateral and Bilateral Pedicle Screw Fixation after Multilevel Lumbar Lateral Interbody Fusion
Authors: Mok James M. , Forsthoefel Craig , Diaz Roberto Leonardo , Lin Ye , Amirouche Farid 
Published: December 2022

Study Design Human Cadaveric Biomechanical Study Objectives Lumbar Lateral Interbody Fusion (LLIF) utilizing a wide cage has been reported as having favorable biomechanical characteristics. We examine the biomechanical stability of unilateral pedicle screw and rod fixation after multilevel LLIF utilizing 26 mm wide cages compared to bilateral fixation. Methods Eight human cadaveric specimens of L1-L5 were included. Specimens were attached to a universal testing machine (MTS 30/G). Three-dimensional specimen range of motion (ROM) was recorded using an optical motion-tracking device. Specimens were tested in 3 conditions: 1) intact, 2) L1-L5 LLIF (4 levels) with unilateral rod, 3) L1-L5 LLIF with bilateral rods. Results From the intact condition, LLIF with unilateral rod decreased flexion-extension by 77%, lateral bending by 53%, and axial rotation by 26%. In LLIF with bilateral rods, flexion-extension decreased by 83%, lateral bending by 64%, and axial rotation by 34%. Comparing unilateral and bilateral fixation, LLIF with bilateral rods reduced ROM by a further 23% in flexion-extension, 25% in lateral bending, and 11% in axial rotation. The difference was statistically significant in flexion-extension and lateral bending (P < .005). Conclusions Considerable decreases in ROM were observed after multilevel (4-level) LLIF utilizing 26 mm cages supplemented with both unilateral and bilateral pedicle screws and rods. The addition of bilateral fixation provides a 10-25% additional decrease in ROM. These results can inform surgeons of the incremental biomechanical benefit when considering unilateral or bilateral posterior fixation after multilevel LLIF.
A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation
Authors: Wan Jun , Tanratana Pansakorn , Roest Mark , Gruber Andras , Pawlinski Rafal , Wolberg Alisa S. , Mackman Nigel , Grover Steven P. 
Published: December 2022

Abstract
Thrombin generation (TG) assays serve as a valuable tool to study the amplifying roles of intrinsic pathway factors in human coagulation and provide functional insights into the increased bleeding observed in individuals deficient in factors (F) XI, IX, or VIII. Mice are used extensively in hemostasis research owing to the availability of coagulation factor–deficient mice. However, phenotypic differences between mouse and human TG have become apparent. In this study, we describe a novel, calibrated mouse whole blood (WB) TG assay used to assess the amplifying roles of intrinsic pathway factors in mouse coagulation. WB- and plasma-TG was triggered with either silica or tissue factor (TF) in samples from wild-type mice and mice deficient for FXII, FXI, or FIX. Expectedly, silica-triggered WB-TG and platelet-poor plasma (PPP)-TG were significantly reduced by deficiencies for FXII, FXI, or FIX. FXII deficiency had no effect on WB-TG or PPP-TG when triggered with TF. However, FXI deficiency resulted in significantly reduced WB-TG triggered by low concentrations of TF but had no effect on TF-triggered PPP-TG. FIX deficiency profoundly reduced WB-TG when triggered by low or high concentrations of TF whereas TG in PPP or platelet-rich plasma was only moderately reduced under these conditions. In conclusion, we have developed a novel mouse WB-TG assay with enhanced sensitivity to FXI- and FIX-dependent amplification of coagulation compared with an established plasma-TG assay. The enhanced sensitivity of WB-TG to FXI and FIX-dependent amplification of coagulation suggests an important role of blood cells in this process.
USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity
Authors: Shin Jaemin , Kim Young Hun , Lee Bin , Chang Jae Ho , Choi Hee Youn , Lee Hoojung , Song Ki Chan , Kwak Man Sup , Choi Ji Eun , Shin Jeon-Soo 
Published: December 2022

AbstractBackgroundHigh mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in response to inflammatory stimuli. Several post-translational modifications (PTMs), including acetylation, phosphorylation, and oxidation, are involved in HMGB1 secretion. However, the E3 ligases of HMGB1 and the mechanism by which DUBs regulate HMGB1 deubiquitination are not well known.MethodsLC–MS/MS, proximity ligation assay, immunoprecipitation were used to identify ubiquitin-specific protease 13 (USP13) as a binding partner of HMGB1 and to investigate ubiquitination of HMGB1. USP13 domain mutant was constructed for domain study and Spautin-1 was treated for inhibition of USP13. Confocal microscopy image showed localization of HMGB1 by USP13 overexpression. The data were analyzed using one-way analysis of variance with Tukey’s honestly significant differencepost-hoctest for multiple comparisons or a two-tailed Student’st-test.ResultsWe identified ubiquitin-specific protease 13 (USP13) as a novel binding partner of HMGB1 and demonstrated that USP13 plays a role in stabilizing HMGB1 from ubiquitin-mediated degradation. USP13 overexpression increased nucleocytoplasmic translocation of HMGB1 and promoted its secretion, which was inhibited by treatment with Spautin-1, a selective inhibitor of USP13.ConclusionTaken together, we suggest that USP13 is a novel deubiquitinase of HMGB1 that regulates the stability and secretion of HMGB1.
Effects of agricultural land use on river biota: a meta-analysis
Authors: Schürings Christian , Feld Christian K. , Kail Jochem , Hering Daniel 
Published: December 2022

AbstractAgriculture, the world’s most dominant land use type, burdens freshwater biodiversity with a multitude of stressors such as diffuse pollution and hydromorphological alteration. However, it is difficult to directly link agricultural land use with biota response as agricultural stressors can also originate from other causes. Also, there is evidence for positive and negative effects of agriculture on organisms, agricultural impact differs strongly with the biological metric and study region considered and agricultural impact differs among practice and type, which in turn affects different organism groups with varying severity. Against this background, our study aimed at assessing, if agricultural land use has a consistent effect on river biota. We conducted a systematic review of the literature, which yielded 43 studies and 76 relationships between agriculture and aquatic organism groups. The relationships were subjected to a meta-analysis using Hedge’s g to calculate the standardized mean difference of effects. Overall, we detected a medium to strong effectg = − 0.74 of agricultural land use on freshwater biota, only marginally influenced by study design, river type and region. Strong differences in biota response could be observed depending on the biological metric assessed, with ecological quality indices of agricultural impairment performing best. Sensitive taxa declined with agricultural impact, while tolerant taxa tended to benefit. In addition, the biota response differed among agricultural types and practices and organism group, with macroinvertebrates showing the strongest effect. Our results quantify the effects of agriculture on riverine biota and suggest biological metric types for assessing agricultural impact. Further research is needed to discriminate between agricultural types and account for intensity.
High-quality genome-scale metabolic network reconstruction of probiotic bacterium Escherichia coli Nissle 1917
Authors: van ‘t Hof Max , Mohite Omkar S. , Monk Jonathan M. , Weber Tilmann , Palsson Bernhard O. , Sommer Morten O. A. 
Published: December 2022

Abstract
Background
Escherichia coli Nissle 1917 (EcN) is a probiotic bacterium used to treat various gastrointestinal diseases. EcN is increasingly being used as a chassis for the engineering of advanced microbiome therapeutics. To aid in future engineering efforts, our aim was to construct an updated metabolic model of EcN with extended secondary metabolite representation.

Results
An updated high-quality genome-scale metabolic model of EcN, iHM1533, was developed based on comparison with 55 E. coli/Shigella reference GEMs and manual curation, including expanded secondary metabolite pathways (enterobactin, salmochelins, aerobactin, yersiniabactin, and colibactin). The model was validated and improved using phenotype microarray data, resulting in an 82.3% accuracy in predicting growth phenotypes on various nutrition sources. Flux variability analysis with previously published 13C fluxomics data validated prediction of the internal central carbon fluxes. A standardised test suite called Memote assessed the quality of iHM1533 to have an overall score of 89%. The model was applied by using constraint-based flux analysis to predict targets for optimisation of secondary metabolite production. Modelling predicted design targets from across amino acid metabolism, carbon metabolism, and other subsystems that are common or unique for influencing the production of various secondary metabolites.

Conclusion
iHM1533 represents a well-annotated metabolic model of EcN with extended secondary metabolite representation. Phenotype characterisation and the iHM1533 model provide a better understanding of the metabolic capabilities of EcN and will help future metabolic engineering efforts.
Isolation, complete genome sequencing and in silico genome mining of Burkholderia for secondary metabolites
Authors: Alam Khorshed , Zhao Yiming , Lu Xuefei , Gong Kai , Zhong Lin , Hao Jinfang , Islam Md. Mahmudul , Islam Saiful , Li Geng , Zhang Youming , Li Ruijuan , Li Aiying 
Published: December 2022

AbstractRecent years, Burkholderia species have emerged as a new source of natural products (NPs) with increasing attractions. Genome mining suggests the Burkholderia genomes include many natural product biosynthetic gene clusters (BGCs) which are new targets for drug discovery. In order to collect more Burkholderia, here, a strain S-53 was isolated from the soil samples on a mountain area in Changde, P.R. China and verified by comparative genetic analysis to belong to Burkholderia. The complete genome of Burkholderia strain S-53 is 8.2 Mbps in size with an average G + C content of 66.35%. Its taxonomy was both characterized by 16S rRNA- and whole genome-based phylogenetic trees. Bioinformatic prediction in silico revealed it has a total of 15 NP BGCs, some of which may encode unknown products. It is expectable that availability of these BGCs will speed up the identification of new secondary metabolites from Burkholderia and help us understand how sophisticated BGC regulation works.
Biocontrol strategies: an eco-smart tool for integrated pest and diseases management
Authors: Jaiswal Durgesh Kumar , Gawande Suresh Janardhan , Soumia P. S. , Krishna Ram , Vaishnav Anukool , Ade Avinash Bapurao 
Published: December 2022

AbstractFor the burgeoning global population, sustainable agriculture practices are crucial for accomplishing the zero-hunger goal. The agriculture sector is very concerned about the rise in insecticide resistance and the Modern Environmental Health Hazards (MEHHs) that are problems for public health due to on pesticide exposure and residues. Currently, farming practices are being developed based on microbial bio-stimulants, which have fewer negative effects and are more efficient than synthetic agro-chemicals. In this context, one of the most important approaches in sustainable agriculture is the use of biocontrol microbes that can suppress phytopathogens and insects. Simultaneously, it is critical to comprehend the role of these microbes in promoting growth and disease control, and their application as biofertilizers and biopesticides, the success of which in the field is currently inconsistent. Therefore, editorial is part of a special issue titled "Biocontrol Strategies: An Eco-smart Tool for Integrated Pest and Disease Management" which focuses on biocontrol approaches that can suppress the biotic stresses, alter plant defense mechanisms, and offer new eco-smart ways for controlling plant pathogens and insect pests under sustainable agriculture.