bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial—First progress report
Authors: Chori Babangida S. , An De‐Wei , Martens Dries S. , Yu Yu‐Ling , Gilis‐Malinowska Natasza , Abubakar Sani M. , Ibrahim Etubi A. , Ajanya Ojonojima , Abiodun Olugbenga O. , Anya Tina , Tobechukwu Iyidobi , Isiguzo Godsent , Cheng Hao‐Min , Chen Chen‐Huan , Liao Chia‐Te , Mokwatsi Gontse , Stolarz‐Skrzypek Katarzyna , Wojciechowska Wiktoria , Narkiewicz Krzysztof , Rajzer Marek , Brguljan‐Hitij Jana , Nawrot Tim S. , Asayama Kei , Reyskens Peter , Mischak Harald , Odili Augustine N. , Staessen Jan A. ,   the UPRIGHT‐HTM Investigators
Published: May 2023

AbstractHigh blood pressure (BP) and type‐2 diabetes (T2DM) are forerunners of chronic kidney disease and left ventricular dysfunction. Home BP telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling risk stratification and personalized prevention. UPRIGHT‐HTM (NCT04299529) is an investigator‐initiated, multicenter, open‐label, randomized trial with blinded endpoint evaluation designed to assess the efficacy of HTM plus UPP (experimental group) over HTM alone (control group) in guiding treatment in asymptomatic patients, aged 55–75 years, with ≥5 cardiovascular risk factors. From screening onwards, HTM data can be freely accessed by all patients and their caregivers; UPP results are communicated early during follow‐up to patients and caregivers in the intervention group, but at trial closure in the control group. From May 2021 until January 2023, 235 patients were screened, of whom 53 were still progressing through the run‐in period and 144 were randomized. Both groups had similar characteristics, including average age (62.0 years) and the proportions of African Blacks (81.9%), White Europeans (16.7%), women 56.2%, home (31.2%), and office (50.0%) hypertension, T2DM (36.4%), micro‐albuminuria (29.4%), and ECG (9.7%) and echocardiographic (11.5%) left ventricular hypertrophy. Home and office BP were 128.8/79.2 mm Hg and 137.1/82.7 mm Hg, respectively, resulting in a prevalence of white‐coat, masked and sustained hypertension of 40.3%, 11.1%, and 25.7%. HTM persisted after randomization (48 681 readings up to 15 January 2023). In conclusion, results predominantly from low‐resource sub‐Saharan centers proved the feasibility of this multi‐ethnic trial. The COVID‐19 pandemic caused delays and differential recruitment rates across centers.
Association between body fat composition and hyperhomocysteinemia in the analysis of the baseline data of the Northwest China Natural Population Cohort: Ningxia Project (CNC‐NX)
Authors: Liu Wanlu , Li Qingqing , Wang Qingan , Ma Shengchao , Yang Xiaoling , Zhang Jiaxing , Qiu Jiangwei , Li Juan , Yang Chan , Li Xiaoxia , Zhang Huiping , Jiang Yideng , Zhang Yuhong , Zhao Yi 
Published: May 2023

AbstractThe authors conducted an observational study to explore the association between body fat composition and the risk of hyperhomocysteinemia (HHcy) and their combined effect on the risk of developing cardiovascular disease (CVD). Adults aged 18–74 years from the Northwest China Natural Population Cohort: Ningxia Project (CNC‐NX) were recruited in this study. Association between body fat composition and HHcy was evaluated by logistic regression model. Restricted cubic spline was used to find nonlinear association. The impact of the interaction between HHcy and body fat composition on CVD was evaluated using the addition interaction model and mediation effect model. In total, 16 419 participants were included in this research. Body fat percentage, visceral fat level, and abdominal fat thickness were positively associated with overall HHcy (pfor trend < .001). Adjusted odds ratios (ORs) in quarter 4 were 1.181 (95% CI: 1.062, 1.313), 1.202 (95% CI: 1.085, 1.332), and 1.168 (95% CI: 1.055, 1.293) for body fat percentage, visceral fat level, and abdominal fat thickness, respectively, compared with those in quarter 1. Subgroup analysis indicated age, estimated glomerular filtration rate (eGFR), total cholesterol (TC), low density lipoprotein cholesterol (LDL‐C), and CVD were the interaction factors of body fat percentage, visceral fat level, abdominal fat thickness with HHcy (allpfor interaction < .05). ORs of CVD were higher in participants with HHcy and high body fat. Body fat composition was positively associated with HHcy, indicating that reducing body, abdominal, and visceral fat content may lower the risk of HHcy and CVD.
Cognitive protection of incretin‐based therapies in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis based on clinical studies
Authors: Chai Sanbao , Liu Fengqi , Yu Shuqing , Yang Zhirong , Sun Feng 
Published: May 2023

AbstractAims/introductionCognitive dysfunction, including mild cognitive impairment and dementia, is increasingly recognized as an important complication of type 2 diabetes mellitus. The aims of the preset study was to investigate the cognitive protection of incretin‐based therapies, including glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors, in patients with type 2 diabetes mellitus.Materials and MethodsPubMed, EMBASE, Cochrane library, Web of Science and PsycINFO were searched from the inception through 17 January 2023 for randomized controlled trials and cohort studies on the association between incretin‐based therapies and cognitive function. A total of 15 studies were finally included in our systematic review, and eight of which were incorporated into our meta‐analysis.ResultsPooled results showed that the Mini‐Mental State Examination score in incretin‐based therapy groups was increased by 1.20 compared with the control group (weighted mean difference 1.20, 95% confidence interval 0.39–2.01). The results of eight studies assessed by the Newcastle Ottawa Quality Assessment Scale and the Cochrane Collaboration's tool, and the quality of the eight studies were at a relatively high level. Egger's regression did not show significant publication bias.ConclusionsCurrent evidence shows that incretin‐based therapies might be more effective, when compared with the other hypoglycemic drugs, for cognitive improvement in patients with type 2 diabetes mellitus.
Speed of clinical improvement in the real‐world setting from patient‐reported Psoriasis Symptoms and Signs Diary: Secondary outcomes from the Psoriasis Study of Health Outcomes through 12 weeks
Authors: Reich A. , Pinter A. , Maul J.‐T. , Vender R. B. , Torres T. , Brnabic A. , Haustrup N. , Reed C. , Schuster C. , Riedl E. 
Published: May 2023

AbstractBackgroundRapid skin improvement is a key treatment goal of patients with moderate‐to‐severe psoriasis (PsO).ObjectivesTo compare the speed of clinical improvement of approved biologics on the symptoms and signs of psoriasis assessed by patients using the validated Psoriasis Symptoms and Signs Diary (PSSD) through 12 weeks.MethodsPsoriasis Study of Health Outcomes (PSoHO) is an international, prospective, non‐interventional study that compares the effectiveness of anti‐interleukin (IL)‐17A biologics versus other biologics, together with pairwise comparisons of ixekizumab versus five individual biologics in patients with PsO. Using the PSSD 7‐day recall period, patients assessed the symptoms (itch, skin tightness, burning, stinging and pain) and signs (dryness, cracking, scaling, shedding/flaking, redness and bleeding) of their psoriasis (0–10). Symptom and sign summary scores (0–100) are derived from the average of individual scores. Percentage change in summary scores and proportion of patients with clinically meaningful improvements (CMI) in PSSD summary and individual scores are evaluated weekly. Longitudinal PSSD data are reported as observed with treatment comparisons analysed using mixed model for repeated measures (MMRM) and generalized linear mixed models (GLMM).ResultsAcross cohorts and treatments, eligible patients (n = 1654) had comparable baseline PSSD scores. From Week 1, the anti‐IL‐17A cohort achieved significantly larger score improvements in PSSD summary scores and a higher proportion of patients showed CMIs compared to the other biologics cohort through 12 weeks. Lower PSSD scores were associated with a greater proportion of patients reporting their psoriasis as no longer impacting their quality‐of‐life (DLQI 0,1) and a high level of clinical response (PASI100). Results also indicate a relationship between an early CMI in PSSD score at Week 2 and PASI100 score at Week 12.ConclusionsTreatment with anti‐IL‐17A biologics, particularly ixekizumab, resulted in rapid and sustained patient‐reported improvements in psoriasis symptoms and signs compared with other biologics in a real‐world setting.
In vivo evaluation of skin of children with LC‐OCT: An objective assessment
Authors: del Río‐Sancho S. , Gallay C. , Ventéjou S. , Christen‐Zaech S. 
Published: May 2023

AbstractBackgroundSeveral non‐invasive skin imaging methods have been developed in recent years. Line‐field confocal optical coherence tomography (LC‐OCT) is one of them, leading to the best compromise in terms of resolution and penetration depth. Skin biopsies are an essential technique in paediatric dermatology, but they are a major stressful event for the child and their parents. Current LC‐OCT studies have not been dedicated to a paediatric population. If, however, LC‐OCT proves to be helpful in children, it may help guide and decrease a certain number of skin biopsies.Objectives(1) To evaluate the feasibility of using LC‐OCT in paediatric patients, and (2) to assess the maturation of skin structures in children over time with this method.MethodsIn vivo LC‐OCT images were collected on six specific body regions (forehead, forearm, chest, back, dorsum of the hand and palmar surface) and in six age groups (between the ages of 0 and 16 years).ResultsIn all body areas and age groups assessed, 9 of 10 images were rated as good‐to‐excellent, the only exception were the images acquired on the palmar surface. LC‐OCT allowed visualizing very well the skin structures up to a penetration of 500 μm. We observed that the body regions located on the upper extremities of the body (forearm, dorsum of the hand and palmar surface) showed both a maturation on their structure and differences in thickness with respect to the other regions evaluated.ConclusionsLC‐OCT can easily be used for non‐invasive imaging of children's skin and allows to document progressive skin changes in the different age groups. It may be a useful asset for imaging and diagnosing superficial skin disorders and as such reducing the number of invasive procedures while increasing the speed of diagnosis in the paediatric population.
The psoriasis area and severity index is an independent risk factor for cardiovascular events: A prospective register study
Authors: Svedbom A. , Ståhle M. 
Published: May 2023

AbstractBackgroundPatients treated with systemics for moderate‐to‐severe psoriasis have increased risk of cardiovascular disease (CVD). However, to the best of our knowledge, there are no data on the association between clinical disease activity and future cardiovascular events in this population. Such data could help identify patients at increased CVD risk and inform the potential for CVD prevention with effective psoriasis treatment.ObjectiveTo estimate the association between the Psoriasis Area and Severity Index (PASI) and cardiovascular events defined as hospitalization for CVD and cardiovascular death.MethodsWe linked prospectively collected data on PASI and CVD risk factors to population‐based administrative data on hospitalizations and causes of death. We estimated the association between PASI and cardiovascular events using Cox proportional hazard models with PASI and Framingham 10‐year cardiovascular risk as time‐varying covariates.ResultsA total of 767 patients with 6264 PASI scores were included. After adjusting for 10‐year cardiovascular risk and prior CVD, a one‐point increase in PASI was associated with a hazard ratio of 1.04 (95% CI: 1.01–1.07) for cardiovascular events. The findings were robust in sensitivity analyses.ConclusionPASI is an independent marker for future cardiovascular events in patients with moderate‐to‐severe psoriasis.
Ciona robusta macrophage migration inhibitory factor (Mif1 and Mif2) genes are differentially regulated in the lipopolysaccharide‐challenged pharynx
Authors: Dumas Francesca , Mauro Manuela , Vazzana Mirella , Arizza Vincenzo , Vizzini Aiti 
Published: May 2023

AbstractThe effects of lipopolysaccharide (LPS) on Mif (macrophage migration inhibitory factor) gene expression in the pharynx (haemapoetic tissue) of Ciona robusta were investigated using quantitative reverse‐transcription PCR (qRT‐PCR) and in situ hybridisation (ISH). To verify the induction of an inflammatory response in the pharynx, a qRT‐PCR analysis was performed to evaluate the change in the expression of proinflammatory marker genes such as Mbl, Ptx‐like, Tnf‐α and Nf‐kb, which were shown to be upregulated 1 h post LPS challenge. The change in the expression of the two Mif paralogs in the pharynx was assessed before and after stimulation, and qRT‐PCR and ISH results showed that, although Mif2 and Mif2 were expressed in clusters of haemocytes in pharynx vessels, only Mif1 expression increased after LPS stimulation. This indicates that the Mif genes are differently regulated and respond to different ambient inputs that need further analysis.
Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reports
Authors: Mac Thi Thom , Castinetti Frederic , Bar Céline , Julia Sophie , Pasquet Marlene , Romanet Pauline , Saveanu Alexandru , Mougel Gregory , Fauquier Teddy , Jullien Nicolas , Barlier Anne , Reynaud Rachel , Brue Thierry 
Published: May 2023

AbstractDeficient anterior pituitary with common variable immune deficiency (DAVID) syndrome is a rare condition characterized by adrenocorticotropic hormone (ACTH) deficiency and primary hypogammaglobulinemia. It is due to heterozygous mutations of the nuclear factor kappa‐B subunit 2 (NFKB2) gene. Only a few isolated cases have been reported since its first description by our team. Through the international multicenter GENHYPOPIT network, we identified a new case of DAVID syndrome. We then conducted an extensive review of the DAVID syndrome cases published from 2012 to 2022. A 7‐year‐old boy was diagnosed with symptomatic hypoglycemia revealing ACTH deficiency. Laboratory tests showed asymptomatic hypogammaglobulinemia. He harbored a heterozygous point mutation in NFKB2 gene (c.2600C > T, p.Ala867Val). His management included hydrocortisone replacement treatment, and he also received subcutaneous immunoglobulins during the Covid‐19 pandemic. We analyzed 28 cases of DAVID syndrome with ACTH deficiency. ACTH deficiency was the only hormone deficiency in 79% of patients, but some patients harbored growth hormone (GH) and thyroid stimulating hormone (TSH) deficiencies. The first presenting symptoms were sinus/pulmonary infections (82%, mean age of 3 years) and alopecia (mean age of 4.7 years). ACTH deficiency was the third presenting condition (mean age at diagnosis of 8.6 years). All patients had hypogammaglobulinemia (decreased IgA and IgM levels), and 57% of patients had at least one autoimmune manifestation. Heterozygous mutations at the 3′end of the NFKB2 gene, coding for the C‐terminal domain of the protein, were identified in all cases. Better knowledge of DAVID syndrome will help clinicians make an early diagnosis to avoid life‐threatening complications.
Impaired cerebral autoregulation in Fabry disease: A case‐control study
Authors: Palaiodimou Lina , Papagiannopoulou Georgia , Bakola Eleni , Papadopoulou Marianna , Kokotis Panagiotis , Moschovos Christos , Vrettou Agathi‐Rosa , Kapsia Eleni , Petras Dimitrios , Anastasakis Aris , Lionaki Sophia , Vlachopoulos Charalambos , Boletis Ioannis N. , Zompola Christina , Tsivgoulis Georgios 
Published: May 2023

AbstractBackground and PurposeCerebral small vessel disease is a common manifestation among patients with Fabry disease (FD). As a biomarker of cerebral small vessel disease, the prevalence of impaired cerebral autoregulation as assessed by transcranial Doppler (TCD) ultrasonography was evaluated in FD patients and healthy controls.MethodsTCD was performed to assess pulsatility index (PI) and vasomotor reactivity expressed by breath‐holding index (BHI) for the middle cerebral arteries of included FD patients and healthy controls. Prevalence of increased PI (>1.2) and decreased BHI (<0.69) and ultrasound indices of cerebral autoregulation were compared in FD patients and controls. The potential association of ultrasound indices of impaired cerebral autoregulation with white matter lesions and leukoencephalopathy on brain MRI in FD patients was also evaluated.ResultsDemographics and vascular risk factors were similar in 23 FD patients (43% women, mean age: 51 ± 13 years) and 46 healthy controls (43% women, mean age: 51 ± 13 years). The prevalence of increased PI (39%; 95% confidence interval [CI]: 20%‐61%), decreased BHI (39%; 95% CI: 20%‐61%), and the combination of increased PI and/or decreased BHI (61%; 95% CI: 39%‐80%) was significantly (p < .001) higher in FD patients compared to healthy controls (2% [95% CI: 0.1%‐12%], 2% [95% CI: 0.1%‐12%], and 4% [95% CI: 0.1%‐15%], respectively). However, indices of abnormal cerebral autoregulation were not associated independently with white matter hyperintensities and presented a low‐to‐moderate predictive ability for the discrimination of FD patients with and without white matter hyperintensities.ConclusionsImpaired cerebral autoregulation as assessed by TCD appears to be highly more prevalent among FD patients compared to healthy controls.
Preoperative slow‐wave sleep is associated with postoperative delirium after heart valve surgery: A prospective pilot study
Authors: Lin Yanjuan , Xu Shurong , Peng Yanchun , Li Sailan , Huang Xizhen , Chen Liangwan 
Published: May 2023

SummaryPostoperative delirium (POD) is a very common neurological complication after valve surgery. Some studies have shown that preoperative sleep disorder is associated with POD, but the correlation between preoperative slow wave sleep (SWS) and POD remains unclear. Therefore, this study aims to identify the correlation between preoperative slow wave sleep and postoperative delirium in patients with heart valve disease. This was a prospective, observational study of elective valve surgery patients admitted to the Heart Medical Center between November 2021 and July 2022. Polysomnography (PSG) was used to monitor sleep architecture from 9:30 p.m. for 1 night before surgery to 6:30 a.m. on the day of surgery. Patients were assessed for postoperative delirium from postoperative day 1 to extubation or day 5 by using the Richmond Agitation/Sedation Scale (RASS) and the Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU). A total of 60 elective valve surgery patients were enrolled in this study. Prolonged N1 (11.44%) and N2 (58.62%) sleep, decreased N3 sleep (8.75%) and REM sleep (18.24%) within normal limits were the overall sleep architecture. Compared with patients without POD, patients with POD had less slow wave sleep 1 night before surgery (5.77% vs 10.88%, p < 0.001). After adjusting for confounding factors, slow wave sleep (OR: 0.647, 95% CI 0.493–0.851, p = 0.002) was found to be a protective factor for postoperative delirium. The preoperative SWS is a predictive factor of the POD in patients undergoing valve surgery. But further studies with larger sample sizes are still needed to elucidate the relationship between preoperative slow wave sleep and postoperative delirium.
Durkheim and realism
Authors: Meadwell Hudson 
Published: May 2023

AbstractThis article examines Durkheim's relationship to realism. I argue that there is enough prima facie evidence of realist commitments in his work that our task should be to consider what kind of realist Durkheim was. I discuss, first of all, Durkheim's epistemics and follow that analysis with a discussion of metaphysical realism in his texts. The first part of the paper covers a wide range of his work; the second part focuses primarily on The Elementary Forms of Religious Life. In a final concluding section, I go on to consider how his epistemic arguments and his philosophical realism might work together to support important parts of his general sociology. Realism is not often brought to bear on Durkheim's work. When it has been, Durkheim has been identified as a naïve realist. These interpretations of Durkheim do not recognize the sophistication of contemporary realism, which does not reduce to naïve representationalism. This paper will sort out Durkheim's realist commitments in his texts, and in light of the variety of realisms consistent with “sophisticated” (that is, non‐naïve) realism.
Evaluation of an HMGA2 variant contribution to height and basal insulin concentrations in ponies
Authors: Clark Brianna L. , Bamford Nicholas J. , Stewart Allison J. , McCue Molly E. , Rendahl Aaron , Bailey Simon R. , Bertin François‐René , Norton Elaine M. 
Published: May 2023

AbstractBackgroundThe HMGA2:c.83G>A variant was identified in Welsh ponies having pleiotropic effects on height and insulin concentration.ObjectiveDetermine whether the HMGA2:c.83G>A variant is associated with decreased height and higher basal insulin concentrations across pony breeds.AnimalsTwo hundred thirty‐six ponies across 6 breeds.MethodsCross‐sectional study. Ponies were genotyped for the HMGA2:c.83G>A variant and phenotyped for height and basal insulin concentrations. Stepwise regression was performed for model analysis using a linear regression model for height and mixed linear model for insulin with farm as a random effect. Coefficient of determination, pairwise comparison of the estimated marginal means and partial correlation coefficients (parcor) were calculated to assess the relationship between HMGA2 genotype and height or insulin.ResultsBreed and genotype accounted for 90.5% of the variation in height across breeds, and genotype explained 21% to 44% of the variation within breeds. Breed, genotype, cresty neck score, sex, age, and farm accounted for 45.5% of the variation in insulin, with genotype accounting for 7.1%. The HMGA2 A allele frequency was 62% and correlated with both height (parcor = −0.39; P < .001) and insulin (parcor = 0.22; P = .02). Pairwise comparisons found A/A ponies were >10 cm shorter than other genotypes. Compared with G/G individuals, A/A and G/A individuals had 4.3 μIU/mL (95% confidence interval [CI]: 1.8‐10.5) and 2.7 μIU/mL (95% CI: 1.4‐5.3) higher basal insulin concentrations, respectively.Conclusions and Clinical ImportanceThese data demonstrate the pleiotropic effects of the HMGA2:c.83G>A variant and its role in identifying ponies at increased risk for insulin dysregulation.
Education and domestic violence: Evidence from a natural experiment in Turkey
Authors: Özer Mustafa , Fidrmuc Jan , Eryurt Mehmet Ali 
Published: May 2023

AbstractWe utilize a natural experiment, an education reform increasing compulsory schooling from 5 to 8 years in Turkey, to obtain endogeneity‐robust estimates of the effect of male education on the incidence of domestic violence against women. We find that husband's education lowers the probability of physical, emotional, and economic violence. Schooling lowers also the likelihood of having an arranged marriage and makes men less inclined to engage in various socially unacceptable behaviors. We show that these findings are very robust to alternative regression specifications and restricted sample estimation. Finally, we argue that assortative mating implies that the educational outcomes of the two spouses are correlated. Our findings are robust to accounting for the husbands' and wives' education jointly. Moreover, when we separate the two effects, we show that the favorable effect of education can be attributed causally to men's education rather than to the education of their wives.