bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase Ib, Double Blind, Randomized Study of Cannabis Oil for Pain in Parkinson's Disease
Authors: Di Luca Daniel G. , Gilmour Gabriela S. , Fearon Conor , Swinkin Emily , Freitas Eliza , Kuhlman Greg , Fox Susan H. , Mestre Tiago 
Published: April 2023

ABSTRACTBackgroundPain is common in Parkinson's disease (PD), but effective therapies are limited.ObjectivesTo determine the maximum tolerated dose (MTD) and safety of formulations of delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) for pain in PD.MethodsIn this phase 1b, double‐blind, randomized, single‐center study, participants were randomized to three formulations of THC/CBD (18:0, 10:10, and 1:20). The MTD, adverse events (AE), and tolerability are described for each formulation.ResultsEight participants were randomized. The MTD was similar among groups (0.8–0.9 mL/daily), and there were no serious AE or study drop‐outs. The most common AE were drowsiness and dizziness (three participants). Epworth sleepiness scale scores were higher in the high CBD formulation (1:20).ConclusionsIn patients with pain and PD, mixed formulations of THC/CBD were tolerated with no serious AE. Considering the safety profile, future phase II studies should be considered.
Managing inventory systems with dual delivery modes and minimum order quantities
Authors: Li Yiran , Yang Chaolin 
Published: April 2023

AbstractWe consider an infinite‐horizon periodic‐review inventory system with dual delivery modes, each with a minimum order quantity (MOQ). The expedited mode provides a shorter lead time than the regular mode but has a higher unit ordering cost. As the optimal ordering policy for a system with dual delivery modes and MOQ requirements is unknown and expected to be very complicated, we propose a class of simple policies called single‐index policies, and we provide an exact procedure to compute the expected long‐run average total cost. Specifically, we first analyze the steady‐state distribution of the inventory position. Then we develop a recursive procedure to determine the steady‐state distribution of the inventory level. In addition, for a special case where ordering from the regular mode follows a base‐stock policy, we apply normal approximation to simplify the exact calculation of the cost. We also study a more complicated class of policies called dual‐index policies. In numerical studies, we first compare the average cost of the single‐index policy with that of a modified single‐index policy without MOQ consideration and the policy for the single‐mode system respectively to investigate the value of the single‐index policy. In addition, we find that the simpler single‐index policy performs close to the dual‐index policy and the optimal policy computed via dynamic programming. Finally, to assess the effectiveness of the normal approximation in the special case, we numerically compare the cost and policy parameters of the exact calculation with those of the normal approximation. The results illustrate that normal approximation not only improves the calculation speed, but also has near‐optimal solutions.
Resilience mediates the effects of self‐care activation and hope on medication adherence in heart failure patients
Authors: Meraz Rebecca , McGee Jocelyn , Ke Weiming , Osteen Kathryn 
Published: April 2023

AbstractMedication adherence is important to heart failure (HF) self‐care. However, the rate of medication nonadherence is approximately 50%. Evidence suggests that self‐care activation and hope may be internal motivators for medication adherence. Empirical data on the association between self‐care activation, hope, and medication adherence among people with HF is sparse, and the mechanism by which these factors influence medication adherence is unclear. The findings of prior research studies suggest that resilience may help to explain the relationship between self‐care activation, hope, and medication adherence. The aim of this cross‐sectional study was to investigate whether resilience mediated the effects of self‐care activation and hope on medication adherence. A total of 174 adults with HF, between the ages of 19 and 92, completed the Patient Activation Measure, The Adult Hope Scale, the 14‐item Resilience Scale, and the Domains of Subject Extent of Nonadherence Scale. Mediation analyses revealed that resilience fully mediated the effects of self‐care activation and hope on medication adherence. Clinicians should consider the person related factors of self‐care activation, hope, and resilience when promoting medication adherence in people with HF. Resilience may play an important role in improving medication adherence in HF patients. More research is needed to understand the connection between resilience, self‐care activation, hope, and medication adherence.
Impedimetric sensors based on diethylphosphonate‐containing poly(arylene ether nitrile)s films for the detection of lead ions
Authors: Chabbah Taha , Chatti Saber , Jaffrezic‐Renault Nicole , Weidner Steffen , Marestin Catherine , Mercier Regis 
Published: April 2023

AbstractThis article describes the elaboration and characterization of diethylphosphonate‐containing polymers coated electrodes as sensors for the detection of heavy metals traces, by electrochemical impedance spectroscopy. Diethylphosphonate groups were chosen as heavy metals binding sites. Two different series of polymers bearing these anchoring groups were synthesized. Whereas the diethylphosphonate groups are directly incorporated in the aromatic macromolecular chain in some polymers, an aliphatic spacer is removing the chelating site from the polymer backbone in others. The influence of the macromolecular structure on the sensing response was studied, especially for the detection of Pb2+, Ni2+, Cd2+ and Hg2+. Polymer P6, including the higher amount of diethylphosphonate groups removed from the polymer chain by a short alkyl spacer gave the higher sensitivity of detection of lead ions, with a detection limit of 50 pM.
Position statement from the International Society for Prenatal Diagnosis on the use of non‐invasive prenatal testing for the detection of fetal chromosomal conditions in singleton pregnancies
Authors: Hui Lisa , Ellis Katie , Mayen Dora , Pertile Mark D. , Reimers Rebecca , Sun Luming , Vermeesch Joris , Vora Neeta L. , Chitty Lyn S. 
Published: April 2023

Key points
What is already known about this topic?

In 2015, the International Society for Prenatal Diagnosis (ISPD) published its first position statement on the use of non‐invasive prenatal testing (NIPT) to screen for aneuploidy. Widespread uptake across the globe and subsequent published research has shed new light on test performance and implementation issues.

What does this study add?

This new position statement replaces the 2015 statement with updated information on the current technologies, clinical experience, and implementation practices.

As an international organization, ISPD recognizes that there are important population‐specific considerations in the organization of prenatal screening and diagnosis. These opinions are designed to apply to high income settings where prenatal screening for aneuploidy is an established part of antenatal care.

This position statement is not a clinical practice guideline but represents the consensus opinion of the current ISPD Board based on the current state of knowledge and clinical practice.
Molecular‐level fabrication strategies for the POSS cross‐linked polybenzoxazines
Authors: Wang Xu , Liu Benben , Chen Dandan , Zhang Donglin , Li Xiangmei , He Jiyu , Yang Rongjie 
Published: April 2023

AbstractIn order to study the dispersion and compatibility of polysilsesquioxane (POSS) with different functional groups in benzoxazine resin, four different polysilsesquioxane/polybenzoxazine (POSS/PBZ) composites are prepared based on 3‐phenyl‐3,4‐dihydro‐2H‐benzoxazine (PHa), unreactive Octaphenylsilsesquioxane (OPS), Mercaptopropyl‐isobutyl silsesquioxane (SPOSS) containing one reactive sulfhydryl group, Aminopropyl‐isobutylsilsesquioxane (NPOSS) containing one reactive amino group and Octa (aminophenyl) silsesquioxane (OAPS) containing eight reactive amino groups, respectively. Scanning electron microscope (SEM), transmission electron microscope (TEM), and transmission electron microscope with probe corrector (AC‐TEM) are used to investigate compatibility. The results indicate that OAPS have very good compatibility and interaction with benzoxazine in the molecular level based on the microstructure. Besides, molecular and mesoscopic dynamic simulations (MesoDyn) also confirms OAPS and PHa have the best compatibility based on the micro and mesoscopic aspects. Then their properties of thermal stability and glass transition temperature (Tg) are identified by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), respectively. While OAPS is beneficial to increase the initial decomposition temperature (T5%) of PBZ by 26 °C and the Tg by 16 °C, comparing with pure PHa. However, NPOSS and SPOSS aggregate into micron‐sized silicon spheres, and OPS precipitates and deposits on the bottom of the resin, which could weaken the property of their thermal stability.
Properties and molecular self‐assembly of liquid crystalline hard–hard diblock and hard–soft–hard triblock copolymers influenced by Flory–Huggins interaction parameter and volume fraction of distinct segments
Authors: Zenati Athmen , Pokhrel Ashish 
Published: April 2023

AbstractTwo series of hybrid liquid crystalline (LC) diblock copolymers (DBCs) and triblock copolymers (TBCs) composed of hard and soft blocks with great control over their molecular masses, dispersities (Mw/Mn = Đ ≤ 1.38) and compositions were prepared via reversible addition‐fragmentation chain transfer polymerization in anisole solvent using new p‐dodecylphenyl‐N‐acrylamide monomer, azobisisobutyronitrile initiator, poly(2‐[2‐(4‐cyano‐azobenzene‐4‐oxy)ethylene‐oxy]ethyl methacrylate) and poly(2‐[2‐(4‐cyano‐azobenzene‐4‐oxy)ethylene‐oxy]ethyl methacrylate)‐block‐poly(n‐butyl methacrylate) macroinitiators. Structures and properties of BCs were characterized by proton nuclear magnetic resonance, gel permeation chromatography, differential scanning calorimeter, optical polarizing microscope, atomic force microscope and grazing‐incidence small angle X‐ray scattering. Kinetic behavior indicated that block copolymerization proceeded with controlled/living characteristics. Every BCs revealed three endothermic transitions corresponding to glassy phase transition, smectic‐to‐nematic phase transition (TS‐N) and melting phase transition. DBC‐1, DBC‐2, TBC‐1 and TBC‐2 with high‐LC volume fractions exhibited strong TS‐N contrasted to DBC‐3, DBC‐4, TBC‐3 and TBC‐4 having low‐LC contents. DBC‐1, DBC‐2, DBC‐3, TBC‐1 and TBC‐2 evidenced smectic C structure while TBC‐3 containing low‐LC segment (39 wt%) showed nematic structure. Morphologies of block copolymer thin films in mixed solvent (Tetrahydrofuran/cyclohexane) vapor annealing system varied significantly, depending on the volume fractions of building blocks and the interactions between the blocks and solvents.
Low versus high dose of postoperative radiotherapy for locally advanced esophageal squamous cell carcinoma: a propensity score‐matched analysis
Authors: Yao Qiwei , Zheng Hongying , Huang Shuyun , Lin Mingqiang , Yang Jun , Li Jiancheng 
Published: April 2023

AbstractObjectiveThis study aimed to investigate the effect of different postoperative radiotherapy doses on the prognosis of patients with esophageal squamous cell carcinoma (ESCC).MethodsA total of 199 patients (aged 18–75 years) with locally advanced ESCC who underwent esophagectomy and postoperative radiotherapy/chemoradiotherapy at the Fujian Cancer Hospital between July 2008 and January 2018 were included. Based on the postoperative radiotherapy dose, the patients were divided into a low‐dose group (50–50.4 Gy; median dose 50 Gy) and a high‐dose group (>50.4 Gy; median dose 60 Gy). Neoadjuvant and adjuvant chemotherapy regimens included PF (fluorouracil and cisplatin) and TP (paclitaxel and cisplatin) regimens. Patients were followed‐up every 3 months in the first 2 years after surgery, every 6 months for the next 3 years, and then subsequently once a year. The primary endpoints were overall survival (OS) and progression‐free survival (PFS) rates. The propensity‐score matching (PSM) method was applied to identify a 1:1, well‐balanced matched cohort with 33 patients in each group for survival comparison.ResultsAmong the 199 patients enrolled in this study, 144 and 55 were in the low‐dose and high‐dose groups, respectively. Univariate and multivariate analyses showed that pathological N classification, vascular tumor emboli, and postoperative radiotherapy dose were independent prognostic factors for both OS and PFS, all p < 0.05. Before PSM, the OS and the PFS of the low‐dose group were significantly longer than those of the high‐dose group, both p < 0.05. After PSM, better OS and PFS rates were observed in the low‐dose group, both p < 0.05. The results showed that patients with pathological stages N0–2 or N3, negative surgical margins, and no vascular tumor emboli could obtain a significant benefit in both OS and PFS after treatment with a low dose of postoperative radiotherapy (50–50.4 Gy). In the subgroup with positive surgical margins, treatment with a low dose of postoperative radiotherapy offered a non‐significant survival benefit compared to treatment with a high dose of postoperative radiotherapy.ConclusionsOur study revealed that for patients with ESCC, the low‐dose group (50–50.4 Gy) had a significantly higher OS and PFS than the high‐dose group (>50.4 Gy). It was suggested that 50–50.4 Gy might be the recommended postoperative radiotherapy dose for ESCC patients.
Performance and validation of the YHGSM global spectral model coupled with the WAM model
Authors: Yang Jinhui , Zhang Xiaojiang , Li Shaoying , Song Junqiang , Wang Huizan , Zhang Weimin , Sun Difu 
Published: April 2023

AbstractIn this article, we describe an implementation of two‐way coupling between the Yin–He Global Spectral Model (YHGSM) and the Wave Model (WAM). The YHGSM atmosphere model gives the surface air water density and 10‐m wind for the WAM model, while the WAM model provides the Charnock coefficient as a response. The effects on the meteorological aptitude of the two‐way coupled system are assessed statistically. The coupled model exhibits a 75% significant positive impact on both the northern (NthH) and the southern hemisphere (SthH) for all metrics at almost all pressure levels. Typhoon track assessments of the coupled model will be implemented later. The results show that the coupling of the WAM model benefits typhoon landfall prediction. Finally, we make a comprehensive comparison of the significant wave height (SWH) between the YHGSM–WAM coupled model and the European Centre for Medium‐Range Weather Forecasts (ECMWF) model with buoy data from the Chinese Ocean Monitoring Network. The comparison shows that the YHGSM–WAM coupled model exhibits more accuracy and predictive stability of SWH forecasts against buoy observations than the ECMWF forecasts. The above results indicate that the YHGSM–WAM coupled model possesses superior performance to uncoupled models.
A motion control framework for autonomous water sampling and swing‐free transportation of a multirotor UAV with a cable‐suspended mechanism
Authors: Panetsos Fotis , Karras George C. , Kyriakopoulos Kostas J. , Oikonomides Odysseas , Kolios Panayiotis , Eliades Demetrios , Panayiotou Christos 
Published: April 2023

AbstractIn this work, we present an end‐to‐end solution for autonomous water sampling by utilizing an unmanned aerial vehicle (UAV) with a cable‐suspended mechanism. Towards this direction, a sampling mechanism is initially designed in such a manner that the water sampling success ratio is maximized. However, the disturbances, acting on the submerged mechanism due to the water flow during the sampling procedure, impede the stabilization of the vehicle above the desired sampling position. Consequently, to achieve the precise hovering of the UAV, the vehicle's sensor suite is further augmented with a load cell, a depth sensor, an ultrasonic sensor, and a camera. The respective measurements are appropriately fused by employing an extended Kalman filter (EKF). Hence, an estimate of the disturbances is available in real‐time and is incorporated into a Model Predictive Control scheme which compensates for the aforementioned disturbances and stabilizes the vehicle above the sampling location. Finally, a complete water sampling mission entails the safe and swing‐free transportation of the mechanism towards the sampling location and, then, to a position where the collected samples are postprocessed by human operators. Consequently, a model predictive controller is employed which ensures the navigation of the vehicle to the desired waypoints while minimizing the swinging motion of the mechanism. The state of the mechanism is obtained by fusing measurements provided by the load cell and the camera with an EKF. The performance of the proposed framework, which aims to address all the aspects of a water sampling mission, is demonstrated through real experiments with an octorotor.
Preparation of Amphiphilic Solid Phase Extraction Material and Its Application in Aqueous Steroid Hormones Extraction
Authors: Zhang Miao , Zhao Jia‐Hui , Liu Bo , Wang Hao‐Dong , Xiao Ning‐Lan , Li Qiang , Li Pei‐Ying , Hu Guo‐Wei , Lai Hua‐Jie , Jin Tao 
Published: April 2023

AbstractThe steroid hormones have attracted increasing attentions in aquatic environment because of their endocrine disrupting effects at trace concentrations. In this work, amphiphilic solid phase extraction material of divinylbenzene‐N‐vinyl‐2‐pyrrolidinone polymer microsphere was synthesized by free radical polymerization. The adsorption of 4 steroid hormones in aqueous solution by prepared amphiphilic microsphere was determined by high‐performance liquid chromatography‐tandem mass spectrometry method. When methyl cellulose and sodium dodecyl sulfonate were used as dispersants, 2,2’‐azobis(2‐methylpropionitrile) was used as initiator, the amphiphilic microsphere was successfully prepared at 80 °C for 6 h. The amphiphilic microsphere has high specific surface area of 774 m2 g−1 with uniform particle size, which is comparable to the commercial solid phase extraction fillers. The amphiphilic microsphere has been successfully applied to the enrichment and detection of 4 steroid hormones (17α‐hydroxyprogesterone, metandienone, norethindrone and boldenone) in natural water. The recoveries of 4 steroid hormones ranged from 83.7 % to 114 %, and the limit of detection were in the range of 0.70–13.5 ng L−1.
Micro‐Cup Architecture for Printing and Coating Asymmetric 2d‐Material‐Based Solid‐State Supercapacitors
Authors: Zhang Chuanfang(John) , Schneider René , Jafarpour Mohammad , Nüesch Frank , Abdolhosseinzadeh Sina , Heier Jakob 
Published: April 2023

AbstractHigh energy density micro‐supercapacitors (MSCs) are in high demand for miniaturized electronics and microsystems. Research efforts today focus on materials development, applied in the planar interdigitated, symmetric electrode architecture. A novel “cup & core” device architecture that allows for printing of asymmetric devices without the need of accurately positioning the second finger electrode here have been introduced. The bottom electrode is either produced by laser ablation of a blade‐coated graphene layer or directly screen‐printed with graphene inks to create grids with high aspect ratio walls forming an array of “micro‐cups”. A quasi‐solid‐state ionic liquid electrolyte is spray‐deposited on the walls; the top electrode material ‐MXene inks‐ is then spray‐coated to fill the cup structure. The architecture combines the advantages of interdigitated electrodes for facilitated ion‐diffusion, which is critical for 2D‐material‐based energy storage systems by providing vertical interfaces with the layer‐by‐layer processing of the sandwich geometry. Compared to flat reference devices, volumetric capacitance of printed “micro‐cups” MSC increased considerably, while the time constant decreased (by 58%). Importantly, the high energy density (3.99 µWh cm−2) of the “micro‐cups” MSC is also superior to other reported MXene and graphene‐based MSCs.
A localized ensemble of approximate Gaussian processes for fast sequential emulation
Authors: Rumsey Kellin N. , Huerta Gabriel , Derek Tucker J. 
Published: April 2023

More attention has been given to the computational cost associated with the fitting of an emulator. Substantially less attention is given to the computational cost of using that emulator for prediction. This is primarily because the cost of fitting an emulator is usually far greater than that of obtaining a single prediction, and predictions can often be obtained in parallel. In many settings, especially those requiring Markov Chain Monte Carlo, predictions may arrive sequentially and parallelization is not possible. In this case, using an emulator procedure which can produce accurate predictions efficiently can lead to substantial time savings in practice. In this paper, we propose a global model approximate Gaussian process framework via extension of a popular local approximate Gaussian process (laGP) framework. Our proposed emulator can be viewed as a treed Gaussian process where the leaf nodes are laGP models, and the tree structure is learned greedily as a function of the prediction stream. The suggested method (called leapGP) has interpretable tuning parameters which control the time‐memory trade‐off. One reasonable choice of settings leads to an emulator with a training cost and makes predictions rapidly with an asymptotic amortized cost of .
Life‐cycle cost analysis and life‐cycle assessment of the second‐generation benchmark building subject to typhoon wind loads in Hong Kong
Authors: Cao Siqi , Wang Jiayao , Tse Tim K. T. 
Published: April 2023

SummaryTall buildings located in Hong Kong can suffer great damage caused by typhoon hazards throughout their lifetimes. In addition, the effect of wind hazards may be exacerbated due to increases in the typhoon intensity and frequency caused by the climate change effect. Therefore, developing a framework to evaluate and quantify the damage caused by wind hazards on tall buildings from the economic perspective is critical for engineers and building owners in designing a cost‐effective tall building. In this study, an economic damage indicator, life‐cycle cost, is measured by using a probabilistic method called life‐cycle cost analysis (LCCA). Moreover, the building sector is one of the biggest contributors to greenhouse gas (GHG) emissions, and the environmental impact that may be generated in intervention activities after wind‐induced damage occurs is analyzed. An environmental impact indicator, embodied carbon emission, is quantified by employing another probabilistic method called life‐cycle assessment (LCA). Therefore, an integrated methodology combining the LCCA and LCA is proposed to evaluate potential damage costs and environmental impact caused by typhoon hazards on tall buildings.