bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of SARS-CoV-2 Infection with Neurological Symptoms and Neuroimaging Manifestations in the Pediatric Population: A Systematic Review
Authors: Kwan Angela T.H. , Al-Kassimi Khaled , Portnoff Jacob S. , Tesla Marija , Hanafimosalman Mehrshad , Gharibi Nima , Ni Tiffany , Sonfack Davaine J.N. , Martyniuk Julia , Arfaie Saman , Mashayekhi Mohammad Sadegh , Mofatteh Mohammad , Jeremian Richie , Moscote-Salazar Luis Rafael , Lee Ángel , Jawad Muhammad Youshay , Guo Ziji , Ceban Felicia , Teopiz Kayla M. , Mansur Rodrigo B. , Ho Roger , Rosenblat Joshua D. , Cao Bing , Rhee Taeho Greg , McIntyre Roger S. 
Published: March 2023

Abstract

Background
Neurological manifestations have been widely reported in adults with COVID-19, yet the extent of involvement among the pediatric population is currently poorly characterized. The objective of our systematic review is to evaluate the association of SARS-CoV-2 infection with neurological symptoms and neuroimaging manifestations in the pediatric population.
Methods
A literature search of Cochrane Library; EBSCO CINAHL; Global Index Medicus; OVID AMED, Embase, Medline, PsychINFO; and Scopus was conducted in accordance with the Peer Review of Electronic Search Strategies form (October 1, 2019 to March 15, 2022). Studies were included if they reported (1) COVID-19-associated neurological symptoms and neuroimaging manifestations in individuals aged < 18 years with a confirmed, first SARS-CoV-2 infection and were (2) peer-reviewed. Full-text reviews of 222 retrieved articles were performed, along with subsequent reference searches.
Results
A total of 843 nonduplicate records were retrieved. Of the 19 identified studies, there were ten retrospective observational studies, seven case series, one case report, and one prospective cohort study. A total of 6,985 individuals were included, where 12.8% of hospitalized patients experienced neurocognitive impairments: MIS-C (24.2%), neuroinflammation (10.1%), and encephalopathy (8.1%) were the most common disorders; headaches (16.8%) and seizures (3.8%) were the most common symptoms. Based on pediatric-specific cohorts, children experienced more drowsiness (7.3% vs. 1.3%) and muscle weakness (7.3% vs. 6.3%) as opposed to adolescents. Agitation or irritability was observed more in children (7.3%) than infants (1.3%).
Conclusion
Our findings revealed a high prevalence of immune-mediated patterns of disease among COVID-19 positive pediatric patients with neurocognitive abnormalities.
Facile green synthesis of Silver nanoparticles using ventilago maderaspatana leaf extract, physicochemical properties and evaluation of antidiabetic potential against streptozotocin induced diabetic albino rats
Authors: Karuppannan P. , Saravanan K. , Ashokkumar M. , Egbuna Chukwuebuka 
Published: March 2023

Abstract
The Silver nanoparticles (NPs) had been bio-synthesized using Ventilago maderaspatana leaf extract. The chemical and physical properties of the biosynthesized Silver NPs had been analyzed by XRD, FE-SEM, TEM, EDAX, FTIR and UV – visible absorption. The diffraction pattern confirmed the cubic structure of the synthesized NPs. The average crystallite size had been calculated by the Debye Scherrer’s method and W-H plot as 11.7 and 9.3 nm, respectively. The FESEM and TEM images confirmed the sized distribution around this range. The antidiabetic efficiency of the biosynthesized Silver NPs were assessed in a group of rats for 10 mg/ kg b.w and 20 mg/kg b.w. Injection of streptozotocin in experimental rat showed elevated level of biochemical parameters such as serum blood glucose, total protein, albumin and HbA1c. Meanwhile, serum insulin (2.50 ± 0.55) and activity of glucokinase (64.50 ± 8.66) levels were diminished. Treatment with silver nanoparticles decreased levels blood glucose, total protein, albumin and HbA1c to normal in dose dependent manner. On the other hand, insulin level (7.55 ± 0.63) and activity of glucokinase (121.50 ± 4.60) level were increased. It was due to the antidiabetic potential of V. maderaspatana mediated silver nanoparticles.
Remarks on the Notions of Maximal Proper Acceleration, Minimal Lapse of Proper Time and Entropy Rate Change
Authors: Torromé Ricardo Gallego 
Published: March 2023

Abstract
It is discussed the relation between maximal proper acceleration and a lower bound to the proper time during which acceleration acts to reach the maximum possible variation in speed. While maximal proper acceleration implies an upper bound on the proper time than an instantaneous inertial observer will be able to measure, this bound is not observed by the physical proper time given by the metric of maximal acceleration. The Unruh temperature formula is extended to the case of hyperbolic observers in spaces of maximal proper acceleration, implying the existence of a maximal temperature. As a consequence, it is shown the existence of a lower bound to the exchange entropy due to interaction with the ambient and an upper bound to the the energy exchanged by charged particles is upper bounded by the energy at rest of the system. We also discuss that for classical point particle, with definite worldline, the existence of a minimal coordinate lapse implies the existence of a maximal acceleration.
The proportion of Episiotomy and Associated Factors among Mothers Who Gave Birth at Public Institutions, Northwest Ethiopia: A cross-sectional study
Authors: Abate Enyew , Alemu Andargew , Hailu Getachew , Derbie Awoke 
Published: March 2023

Abstract

Background Episiotomy is the surgical enlargement of the posterior aspect of the vagina by an incision made on the perineum during the last phase of the second stage of labor. The rate of episiotomy is on the decline in developed countries but remains high in less industrialized countries. Studies are limited to showing the extent of the problem and the reasons behind episiotomy practice. The objective of this study was to assess the proportion of episiotomy practice and its associated factors among mothers who gave birth at public health institutions in Debark town, Northwest Ethiopia. Methods Institutional based cross-sectional study was conducted among 410 mothers who gave birth from 1 April 2021 to 30 June 2021 in Debark town. A systematic random sampling technique was used to select study participants. Data were entered into Epi data version 3.1, coded, cleaned, and then exported to SPSS version 23 for analysis. Variables with p-value < 0.25 during the bivariable analysis were considered for multivariable logistic regression analysis. Stepwise backward elimination was done to select variables associated with episiotomy and Hosmer and Lemeshow test was used to check model fitness. Adjusted odds ratio with a 95% confidence interval and a p-value < 0.05 was used to decide the association of independent variables with the outcome variable. Results The proportion of episiotomy among the study participants was 42.9% (95% CI; 38–48%). Face presentation (AOR = 4.15; 95% CI (1.22,14.1) P = 0.02), Previous episiotomy (AOR = 3.73; 95% CI (1.95,7.15); P < 0.001), Short birth spacing interval (AOR = 1.66;95% CI (1.01,2.73); P = 0.04), perineal laceration (AOR = 2.18; 95% CI (1.16,4.08); P = 0.014) and induced labor (AOR = 2.12; 95% CI (1.08, 4.14); P = 0.028) were significantly associated with episiotomy. Conclusions The prevalence of episiotomy in the study area is high. It is significantly associated with face presentation, short birth spacing interval, induced labor, perineal tear, and previous episiotomy. In the presence of the aforementioned factors, judicious use of episiotomy is warranted.
Evaluation of the health-related quality of life and associated factors in Zimbabwean adults living with HIV: A cross-sectional study
Authors: Tigirigi Tendai Orial , Sithole Grace Yolanda , Chakara Princess , Chirombo Gracious Zvikomborero , Chiweza Annamore Rutendo , Mubayiwa Trish Rutendo , Muchemwa Sidney , Chibanda Dixon , Dambi Jermaine M. 
Published: March 2023

Abstract
Objective: HIV remains a global burden, with the Sub-Saharan Africa (SSA) region reporting the largest number of people living with HIV/AIDS (PLHIV). An exponential improvement in the accessibility and uptake of antiretroviral treatment across SSA has significantly improved outcomes for PLHIV. Hence, HIV care goals have shifted from reducing mortality and morbidity to improving health-related quality of life (HRQoL). This study uses generic and condition-specific HRQoL outcomes to holistically determine the HRQoL of Zimbabwean adult PLHIV and associated factors. HRQoL is a dynamic subject construct that warrants continuous evaluation to provide meaningful feedback to various stakeholders. We enrolled 536 adults PLHIV in Zimbabwe. Collected data were analyzed through descriptive statistics and multivariate binary logistic regression.
Results: Our study shows a high HRQoL perception by Zimbabwean PLHIV. Anxiety, depression, and poor environmental health were widely reported domains influencing HRQoL. Also, being aware of HIV status for over a year, not experiencing an adverse event, being married, having adequate finances and food security and having higher educational status were associated with higher HRQoL. It is essential to integrate mental health care into routine HIV care to improve treatment outcomes and HRQoL. Last, implementing bespoke multisectoral HRQoL-enhancement interventions is paramount.
STUDENTS' RESPONSES IN ONLINE PEER FEEDBACK IN EFL WRITING INSTRUCTION
Authors: Rahayu Nanik Sri 
Published: March 2023

As a supplementary of teacher’s feedback, peer feedback activity is believed can help the students improve their writing achievement. During and after the pandemic, teachers often applied online teaching for certain reasons, including in practicing peer feedback which can be done via different application. This study aims at investigating the types of comments appeared when the students conduct peer feedback in quip application. The study involved a class in which the teacher applied peer feedback via quip. This research is a descriptive quantitative in which the data was collected through documentation. The students’ responses were analyzed using types of comments proposed by Jun Liu and Hansen. The result of the study showed that the students made a lot of comments during online peer feedback activity. This study demonstrates that students are very active in giving comments during online peer feedback; however, it also underlines that the students still produced many local and non-revision comments.
Characterizing a new type of nelsonite recognized in the Damiao anorthosite complex, North China Craton, with implications for the genesis of giant magmatic Fe-Ti oxide deposits
Authors: Li Li-Xing , Zi Jian-Wei , Li Hou-Min , Meng Jie 
Published: March 2023

Abstract
Nelsonite (Fe-Ti oxide-apatite rock) devoid of silicates offers a rare opportunity to investigate the magma processes for the formation of magmatic Fe-Ti oxide deposits. Both fractional crystallization and silicate liquid immiscibility have been put forward, but the lack of robust evidence has hindered unambiguously distinguishing the role of these two processes in Fe-Ti mineralization. The nelsonite and associated Fe-Ti-P-rich rocks hosted in the Proterozoic Damiao anorthosite complex represent a typical example for studying Fe-Ti ore-forming processes. We recognized a new type of nelsonite (type-I) in the Damiao complex, which is distinct from the two known types of nelsonite (type-II and type-III) from the same complex. The type-I nelsonite is characterized by its coexistence with oxide-apatite gabbronorite and granite in the same dike, and all these rocks have identical emplacement ages (1740 ± 7 Ma), subparallel REE patterns, and major-element compositions lacking intermediate compositions, suggesting derivation from conjugate Fe- and Si-rich melts generated by silicate liquid immiscibility. The large type-II nelsonite bodies form irregular dikes along fractures in anorthosite and constitute the major ore type. The type-III nelsonite occurs as conformable layers or pods within oxide-apatite gabbronorite and pyroxenite, and occupies the end part of the type-II dike. The latter two types of nelsonites formed by extensive fractional crystallization of residual magma with crystal accumulation and subsequent hydrothermal replacement. During residual magma evolution, silicate liquid immiscibility was crucial for Fe-Ti-P enrichment, fractional crystallization was responsible for enhancing oxide-apatite concentrations, and hydrothermal replacement was effective for mobilizing oxide-apatite concentrations. Our newly recognized nelsonite provides an unambiguous, outcrop-scale, field evidence for the operation of silicate liquid immiscibility process. We show that giant magmatic Fe-Ti oxide orebodies can form by a combination of processes involving silicate liquid immiscibility, fractional crystallization and hydrothermal mobilization.
A pre-training model based on CFD for open-channel velocity field prediction with small sample data
Authors: Lin Ruixiang , Zhou Xinzhi , Li Bo , He Xin 
Published: March 2023

Abstract
Accurately obtaining the distribution of the open-channel velocity field in hydraulic engineering is extremely important, which is helpful for better calculation of open-channel flow and analysis of open-channel water flow characteristics. In recent years, machine learning has been used for open-channel velocity field prediction. However, effective training of data-driven models in machine learning heavily depends on the diversity and quantity of data. In this paper, a CFD-based pre-training neural network model (CFD–PNN) is proposed for accurate open-channel velocity field prediction, allowing the adaption to the task with small sample data. Also, a cross-sectional velocity field prediction method combining the computational fluid dynamics (CFD) and machine learning is established. By comparing CFD–PNN with six other neural network algorithm models and the CFD model, the results show that, in the case of small sample data, the CFD–PNN model can predict a more reasonable open-channel velocity field with higher prediction accuracy than other models. The average error of the velocity calculation for the trapezoidal open-channel cross-section is about 3.62%. Compared with other models, the accuracy is improved by 0.3–2.8%.
Instantaneous physical rainfall–runoff prediction technique using a power–law relationship between time to peak and peak flow of an instantaneous unit hydrograph and the rainfall excess intensity
Authors: Jeong Minyeob , Kim Dae-Hong 
Published: March 2023

AbstractThe traditional instantaneous unit hydrograph (IUH) is very useful for theoretical analysis and practical forecasting of floods owing to its linear assumptions. Although various revised methods to overcome the unphysical assumptions have been proposed, it is still difficult to obtain efficiently a nonlinear IUH of diverse rainfall excess intensities in a watershed. In this study, we proposed practical and physical interpolation techniques to derive new IUHs from at least two existing IUHs corresponding to diverse rainfall excess intensities in a watershed. To interpolate the new IUHs, mass conservation law and power–law relationships between rainfall excess intensities and the peak flow and time to peak of IUHs were used. By employing convolution integration, surface rainfall–runoff hydrographs for timely varying rainfall events were derived. For verification, we applied the proposed technique to three real watersheds with different sizes ranging from 0.036 to 1,047 km2. All flood prediction procedures were completed instantly, stably and the prediction results showed the accuracy of Nash–Sutcliffe efficiency (NSE) = 0.55–0.93 and coefficient of determination (R2) = 0.72–0.94.
Acute Thrombocytopenia after Administration of Heparin and Tirofiban: Differential Diagnosis and Treatment
Authors: Konstantinou Thrasivoulos , Sdogkos Evangelos , Vogiatzis Ioannis 
Published: March 2023

Introduction:Drug-induced thrombocytopenia (DIT) is a condition characterized by low platelet count after administration of a variety of drugs. It is most commonly seen in patients treated with heparin. Its diagnosis is complicated when more than one DIT-causing drug is co-administered. Patients with thrombocytopenia may present with minor or major hemorrhages, depending on the severity of the recess of the platelets.Case Description:We herein report an uncommon presentation of acute IIb/IIIa glycoprotein inhibitor-induced thrombocytopenia in a 50-year-old male who suffered from myocardial infarction. Serial complete blood counts revealed low platelet counts, rising after discontinuation of the administered IIb/IIIa inhibitor. Recovery was prompt, complete, and sustained with minimal costs.Conclusion:This report highlights the importance of prompt recognition of severe thrombocytopenia caused by IIb/IIIa inhibitors, particularly tirofiban, by measuring platelet count before and after the initiation of tirofiban, as it can be resolved by the interruption of its infusion and early supportive treatment.
circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR-
515-5p and Up-regulating CXCL6
Authors: Guo Qiuxia , Ding Xiangwu , Lv Fei , Wang Aixiang , Wang Jing 
Published: March 2023

Background:
Gastric cancer (GC) is the most common cancer globally. Recent research has
suggested that circular RNAs (circRNAs) play crucial roles in GC tumorigenesis and progression. The
present study is performed to clarify the possible mechanism of circRNA has_circ_0006089
(circ_0006089) in GC.

Methods:
The differentially expressed circRNAs were screened out by analyzing the dataset GSE83-
521. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect
circ_0006089, miR-515-5p and CXCL6 expression levels in GC tissues and cell lines. CCK-8, BrdU
and Transwell assays were adopted to examine the biological function of circ_0006089 in GC cells.
The interaction between miR-515-5p and circ_0006089, as well as between CXCL6 and miR-515-5p,
was confirmed through bioinformatics, RNA immunoprecipitation (RIP) assay, dual-luciferase reporter
gene assay and RNA pull-down assay.

Results:
Circ_0006089 was significantly upregulated in GC tissues and cells, and miR-515-5p was
remarkably downregulated. After knocking down circ_0006089 or overexpressing miR-515-5p, the
growth, migration and invasion of GC cells were markedly reduced. In terms of mechanism, miR-515-
5p was verified to be the target of circ_0006089, and CXCL6 was validated as miR-515-5p’s
downstream target gene. Inhibiting miR-515-5p reversed the inhibitory effect knocking down
circ_0006089 had on GC cell proliferation, migration and invasion.

Conclusion:
Circ_0006089 facilitates the malignant biological behaviors of GC cells via the miR-515-
5p/CXCL6 axis. Circ_0006089 can probably act as one of the important biomarkers and therapeutic
targets in GC treatment strategies.
An Insight into MptpB Inhibitors as a Key Strategy to Treat MDR and XDRTuberculosis
Authors: Jain Madhur , Gollapudi Sirisha , Khatik Gopal L. 
Published: March 2023

Abstract:
Tuberculosis (TB) is a chronic, air-borne infectious disease caused by Mycobacterium tuberculosis
(Mtb), which prominently affects the lungs and usually manifests in other organs. TB is preventable and curable
but what makes it challenging is the emergence of resistance to the available treatment options. MDR-continued
TB's expansion is one of the world's most pressing and difficult problems. Mtb revives via the reciprocity between
Mycobacterium and host signalling pathways. Mtb secretes a virulence component called Mycobacterium
tuberculosis protein tyrosine phosphatase (MptpB), which helps to survive against host macrophages. It indicates
that targeting secreted virulence factors offers more benefits to circumvent the emergence of resistance.
Many effective inhibitors of MptpA and MptpB have been discovered, providing a solid foundation for future
research and development. Aside from possessing a structurally unique binding site in the Mtb enzyme,
MptpB's minimal resemblance to other human phosphatases provides a broad platform for improving selectivity
over host PTPs. We believe that addressing several parts of infection processes in the host and bacteria with
combination therapy is the greatest way to reduce treatment burden and medication resistance. We have discussed
the recent potent, selective, and efficacious MptpB inhibitors, such as natural and marine-based, isoxazole-
linked carboxylic acid-based, oxamic acid-based, and lactone-based inhibitors, as potential strategies for
treating TB.
Albiflorin Alleviates Sepsis-induced Acute Liver Injury through
mTOR/p70S6K Pathway
Authors: Liu Yanan , Feng Lizhi , Yao Lan 
Published: March 2023

Background:
Sepsis often induces hepatic dysfunction and inflammation,
accounting for a significant increase in the incidence and mortality rates. To this end,
albiflorin (AF) has garnered enormous interest due to its potent anti-inflammatory activity.
However, the substantial effect of AF on sepsis-mediated acute liver injury (ALI),
along with its potential mechanism of action, remains to be explored.

Methods:
An LPS-mediated primary hepatocyte injury cell model in vitro and a mouse
model of CLP-mediated sepsis in vivo were initially built to explore the effect of AF on
sepsis. Furthermore, the hepatocyte proliferation by CCK-8 assay in vitro and animal
survival analyses in vivo for the survival time of mice were carried out to determine an
appropriate concentration of AF. Then, flow cytometry, Western blot (WB), and TUNEL
staining analyses were performed to investigate the effect of AF on the apoptosis of
hepatocytes. Moreover, the expressions of various inflammatory factors by ELISA and
RT-qPCR analyses and oxidative stress by ROS, MDA, and SOD assays were determined.
Finally, the potential mechanism of AF alleviating the sepsis-mediated ALI via
the mTOR/p70S6K pathway was explored through WB analysis.

Results:
AF treatment showed a significant increase in the viability of LPS-inhibited
mouse primary hepatocytes cells. Moreover, the animal survival analyses of the CLP
model mice group indicated a shorter survival time than the CLP+AF group. AF-treated
groups showed significantly decreased hepatocyte apoptosis, inflammatory factors,
and oxidative stress. Finally, AF exerted an effect by suppressing the mTOR/p70S6K
pathway.

Conclusion:
In summary, these findings demonstrated that AF could effectively alleviate
sepsis-mediated ALI via the mTOR/p70S6K signaling pathway.
Research Progress on the Mechanism of Intestinal Barrier Damage and
Drug Therapy in a High Altitude Environment
Authors: Cheng Junfei , Sun Yuemei , Zhao Yilan , Guo Qianwen , Wang ZiHan , Wang Rong 
Published: March 2023

Abstract:
The plateau is a typical extreme environment with low temperature, low oxygen and high
ultraviolet rays. The integrity of the intestinal barrier is the basis for the functioning of the intestine,
which plays an important role in absorbing nutrients, maintaining the balance of intestinal flora, and
blocking the invasion of toxins. Currently, there is increasing evidence that high altitude environment
can enhance intestinal permeability and disrupt intestinal barrier integrity. This article mainly focuses
on the regulation of the expression of HIF and tight junction proteins in the high altitude environment,
which promotes the release of pro-inflammatory factors, especially the imbalance of intestinal flora
caused by the high altitude environment. The mechanism of intestinal barrier damage and the drugs to
protect the intestinal barrier are reviewed. Studying the mechanism of intestinal barrier damage in high
altitude environment is not only conducive to understanding the mechanism of high altitude environment
affecting intestinal barrier function, but also provides a more scientific medicine treatment method
for intestinal damage caused by the special high altitude environment.