bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of mindfulness-based cognitive therapy (MBCT) online training on perceived stress of nursing students: An interventional study
Authors: Khataei Roya , Khoshnoud Zohreh , Ahmadi Atefeh , Moadeb Shabnam , Bagherian Behnaz 
Published: May 2023

Abstract
Background: Perceived stress is a psychological state or process during which a person perceives a threat to their physical and psychological well-being. One of the most important sources of stress in nursing students is issues related to the nature of the nursing field, especially the completion of clinical internships. Mindfulness-based cognitive therapy (MBCT) can affect a person’s perceived stress. To this end, the present study sought to explore the effect of MBCT online training on the level of stress perceived from the clinical environment in nursing students of Kerman University of Medical Sciences in the academic year 2020-2021.
Methods: This two-group interventional study was conducted on 82 fourth- and sixth-semester nursing students at Kerman University of Medical Sciences. The level of perceived stress was evaluated before and after the MBCT online training intervention using Cohen’s Perceived Stress Scale-14 (PSS). The participants were divided into intervention and control groups, and the participants in the intervention group attended a 4-session online program for 120-150 minutes, along with daily exercises for 45 minutes. The effect of the intervention on the students’ level of perceived stress was evaluated immediately after and one month after the training intervention. The collected data were analyzed using descriptive statistics and inferential statistics including the chi-square test, paired samples t-test, and independent samples t-test.
Results: The participants’ average was 21 years, and no significant difference was observed in the demographic variables between the participants in the intervention and control groups. The results showed that the perceived stress in the participants in the intervention group after the MBCT online training program decreased by three points (P-value=0.024). An analysis of positive and negative perceptions of stress indicated that positive perceptions in the students in the intervention group decreased significantly and the average score of positive perceptions after the intervention decreased from 13.195 to 10.71 (p-value = 0.002). The results also showed that the intervention significantly reduced the level of perceived stress in students after the intervention, but its effect was not prolonged.
Conclusion: The data in this study showed that the implementation of MBCT online training in clinical settings can reduce the stress perceived by nursing students and nurses working in hospitals, and help them provide better services and nursing care to patients. For this reason, future studies should investigate the long-term effect of MBCT interventions on nursing students’ perceived stress.
Assessment of air pollution removal by urban trees based on the i-Tree Eco Model: The case of Tehran, Iran
Authors: Rasoolzadeh Reihaneh , Dinan Naghmeh Mobarghaee , Esmaeilzadeh Hassan , Rashidi Yousef , Sadeghi Seyed Mohammad Moein 
Published: May 2023

Abstract
As the population grows and economic development accelerates, urbanization is also increasing at a fast pace and this has resulted in severe air pollution that poses a significant threat to human health. Air quality issues have become increasingly serious in metropolises like Tehran (Iran) in recent years. Hence, this study aims to estimate the role of Tehran’s urban trees in air pollution removal and evaluate this ecosystem service’s economic value, based on the i-Tree Eco model. This study’s results illustrate that Tehran urban trees produce 160,271.4 tons of oxygen and remove 1286.42 tons of pollutants in 2020. The rate of air pollution removal varies among pollutants which are 134.83, 299.68, 270.32, 0.68, 489.41, and 91.50 t yr− 1 for the CO, NO2, O3, PM2.5, PM10, and SO2, respectively, with an associated monetary value of US$ 1,536,619. This effect is small compared to the amount of pollution emitted in 2020 (0.17%) due to the high emissions rate and low per capita green space in Tehran. Therefore, tree planting should not be considered a single solution to emission reduction but rather a complementary one. The findings could serve as a basis for future replication in other locations and serve as a guide for enhancing urban green spaces to promote sustainable urban development.
Multistage entanglement swapping using superconducting qubits in the absence and presence of dissipative environment without Bell state measurement
Authors: Salimian S. , Tavassoly M. K. , Ghasemi M. 
Published: May 2023

Abstract
In recent decade the entangled state generation is of great importance in the quantum information processing and technologies. In this paper, producing the distributed entangled state of superconducting (SC) qubits is considered using an entanglement swapping protocol in three successive stages. The SC qubit pairs (i, i+1 with i=1, 3, 5, 7), where each pair of the qubits has been placed on a separate chip, are initially prepared in maximally entangled states. The external magnetic fields on capacitively coupled pairs (2, 3) and (6, 7) are implemented for modulating the qubits. Then, the SC qubits (1, 4) and (5, 8) are converted into entangled states via operating proper measurements instead of Bell state measurement (which is generally a hard task). Finally, the distributed entangled state of target SC qubits (1, 8) can be obtained by applying external magnetic fields on qubits (4, 5) and operating suitable measurements. This process is studied in the absence and presence of thermal decoherence effects. The concurrence, as a measure of entanglement between two qubits, success probability of the distributed entangled states and fidelity are evaluated, by which we find that the state of target SC qubits (1, 8) is converted to Bell state at some moments of time. Also, there exist appropriate conditions in which maximum of success probability of the obtained states in each stage approaches 1. Also, the maxima of concurrence and success probability gradually decrease due to thermal noise as time goes on. Moreover, convincing amounts of fidelity, success probability and entanglement can be obtained for the achieved entangled states.
Integration of transcriptome analysis with CRISPR/Cas9 technology provides new opportunities for uncovering transcriptional regulation of hyperaccumulation in Sedum plumbizincicola
Authors: Zhang Yixin , Mo Yanlan , Han Liyuan , Wu Xiaotong , Peng Xin , Xue Boyang , Wu Longhua , Sun Zhenyuan , Xu Wenzhong 
Published: May 2023

Abstract
Cadmium-hyperaccumulator Sedum plumbizincicola possesses strong capacities of Cd transport, accumulation and detoxification, but the transcriptional regulation mechanisms of Cd hyperaccumulation remain unknown. In this study, we examined the comparative transcriptome between S. plumbizincicola and non-accumulator Sedum alfredii with or without Cd treatments. Many differentially expressed genes involved in heavy metal transport and detoxification were found to be abundantly expressed in S. plumbizincicola. Meanwhile, a large number of differentially expressed transcription factor genes had been identified and revealed the complexity of transcriptional regulatory networks. Four transcription factor genes that were highly expressed in the roots of S. plumbizincicola were screened as candidate genes for creating CRISPR/Cas9 knockout mutations. The mutant lines of SpARR11 and SpMYB84 exhibited decreased Cd accumulation in the aboveground parts, indicating that the two transcription factors may be involved in the regulation of the Cd hyperaccumulation in S. plumbizincicola. Although further research will be needed to determine the precise targeted genes of these transcription factors, this study combining transcriptome analysis and CRISPR/Cas9 genome editing technology offers unprecedented opportunities to mine transcription factors related to Cd hyperaccumulation and contributes to uncovering the transcriptional regulation mechanism of hyperaccumulation in S. plumbizincicola.
TerC Proteins Function During Protein Secretion
to Metalate Exoenzymes
Authors: Helmann John , He Bixi , Sachla Ankita 
Published: May 2023

Abstract
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC family proteins function in metalation of enzymes during export through the general secretion (Sec-dependent) pathway. Bacillus subtilis strains lacking MeeF(YceF) and MeeY(YkoY) have a reduced capacity for protein export and a greatly reduced level of manganese (Mn) in the secreted proteome. MeeF and MeeY copurify with proteins of the general secretory pathway, and in their absence the FtsH membrane protease is essential for viability. MeeF and MeeY are also required for efficient function of the Mn2+-dependent lipoteichoic acid synthase (LtaS), a membrane-localized enzyme with an extracytoplasmic active site. Thus, MeeF and MeeY, representative of the widely conserved TerC family of membrane transporters, function in the co-translocational metalation of Mn2+-dependent membrane and extracellular enzymes.
Influence of Government Policies on Hand Washing and Vaccine Uptake in Kenya, Uganda, And Tanzania in Relation to COVID-19 Prevention and Control: A Systematic Review
Authors: Muchangi Josphat Martin , Mturi James , Mukasa Hajra , Kithuki Kioko , Kosgei Sarah Jebet , Kanyangi Lennah Muhoja , Mararo Rogers , Nankaja Mauren 
Published: May 2023

Abstract
Background: The government’s role in influencing policies related to COVID-19 vaccine distribution and handwashing uptake is essential in controlling the spread of the virus. This study aims to systematically review published studies to determine how government policies have influenced hand washing and vaccine uptake in Kenya, Uganda and Tanzania in relation to COVID-19 prevention and control.
Methods and analysis: Using systematic approach, this study reviewed 136 published research papers to examine and understand how government policies have influenced hand washing and COVID-19 vaccine uptake in Kenya, Uganda and Tanzania in relation to COVID-19 prevention and control. The search strategy was applied in three databases, papers were selected using strict inclusion and exclusion criteria including papers published between December 2019 and January 2023. The review was undertaken according to the PRISMA-P 2015 checklist and the PRISMA flow diagram was used for research article selection and screening.
Findings: Eleven of the initial records were found eligible for review. The findings reveal that the government has a role in influencing policies related to COVID-19 vaccine distribution and handwashing uptake. Study results indicate that employment of public health campaigns and communication strategies by the government in Uganda increased vaccine acceptance and hand hygiene uptake. Similarly, results revealed that government efforts in making hand hygiene accessible increases uptake of handwashing. In Kenya, government efforts show informal settlements access soap and clean water at markets, results revealed that government incentives such as cash could increase vaccination rates and vaccination reminders combined with cash incentives increased childhood immunization coverage. Studies have indicated monitoring and enforcing compliance increases vaccine and handwashing uptake.
Conclusion: The government’s role in influencing policies that promote handwashing and vaccine uptake. The effectiveness of these polices are also influenced by various factors including safety and efficacy, access to information among other. It is important to address these factors to successfully implementation these policies.
Registration: PROSPERO ID CRD42023396319; registered on 2nd February 2023
Clinical significance of antinuclear antibody as prognostic marker for first-line pembrolizumab in advanced non-small cell lung cancer
Authors: Mouri Atsuto , Kaira Kyoichi , Yamaguchi Ou , Hashimoto Kosuke , Miura Yu , Shiono Ayako , Kawasaki Tomonori , Kobayashi Kunihiko , Imai Hisao , Kagamu Hiroshi 
Published: May 2023

Abstract
Background
The relationship between antinuclear antibody (ANA) and the efficacy of programmed death-1 (PD-1) blockade remains controversial. Here, we investigated the prognostic significance of ANA titer in patients with non-small cell lung cancer (NSCLC) receiving pembrolizumab monotherapy as the first-line treatment, compared with that of platinum-based chemotherapy with PD-1 blockade.
Methods
Our clinical data based on the ANA titer (1:80) were retrospectively reviewed for patients with advanced NSCLC, who were treated with first-line pembrolizumab monotherapy and platinum-based chemotherapy with PD-1 blockade. Immunohistochemical staining for tumor-infiltrating lymphocytes such as CD4, CD8 and Foxp3 was performed.
Results
Among 106 patients treated with pembrolizumab, 19 (17.9%) tested positive for ANA. The incidence of grade 3 or 4 immune-related adverse events (irAEs) was significantly different between patients with positive and negative ANA. Progression-free survival (PFS) and overall survival (OS) were significantly better in patients with positive ANA than in those with negative ANA, and positive ANA was identified as an independent prognostic predictor, particularly in the subgroup with programmed death ligand-1 (PD-L1) ≥ 50%. However, no statistically significant difference in PFS and OS based on the ANA titer was observed in 59 patients treated with combinational chemotherapy and immunotherapy. High numbers of intratumoral Foxp3 and stromal CD8 were significantly associated with negative ANA.
Conclusions
Assessment of preexisting ANA titers was useful to prognose PD-1 blockade as a first-line setting, particularly for the PD-L1 ≥ 50% subgroup, but not in the case of combined immunotherapy and chemotherapy.
Riemann-Hilbert method and soliton dynamics for a mixed spectral complex mKdV equation with time-varying coefficients
Authors: Zhang Sheng , Zhou Huimin 
Published: May 2023

Abstract
This paper reports the feasibility of using Riemann-Hilbert method (RHM) to reveal the soliton dynamics with variable velocity and amplitude in mixed spectral nonlinear integrable systems. To achieve this goal, we consider a novel mixed spectral complex mKdV equation (mscmKdV) with time-varying coefficients. Firstly, Lax representation of the time-varying coefficient mscmKdV equation is first abstracted from Ablowitz-Kaup-Newell-Segur (AKNS) matrix spectral problem equipped with a mixed spectrum. With the help of the Lax representatoin, a Riemann-Hilbert problem (RHP) associating with the mscmKdV equation is then established. Due to the confirmation of solvability of the RHP, scattering data used for recostructing the potential are further determined, and N-soliton solution of the mscmKdV equation is finally obtained. In addition, the one- and two-soliton solutions are shown to explore the characteristics of soliton dynamics in the mscmKdV equation. It is revealed from the mscmKdV equation that compared with the constant velocity and amplitude propagation of a soliton in the background of constant-coefficient isospectral model, the one of variable-coefficient isospectral system propagates with variable velocity but constant amplitude, while for the case of non-spectrum, whether its coefficients are variable or not, soliton always propagates with variable velocity and amplitude.
Predictive Value of 99mTc-MAA-based Dosimetry in Personalized 90Y-SIRT planning for Liver Malignancies
Authors: Riveira-Martin Mercedes , Akhavanallaf Azadeh , Mansouri Zahra , Wolf Nicola Bianchetto , Salimi Yazdan , Ricoeur Alexis , Mainta Ismini , Garibotto Valentina , Medina Antonio Lopez , Zaidi Habib 
Published: May 2023

Abstract
Background Selective internal radiation therapy (SIRT) with 90Y radioembolization aims to selectively irradiate liver tumors by administering radioactive microspheres under the theragnostic assumption that the pre-therapy injection of 99mTc labeled macro-aggregated albumin (99mTc-MAA) provides an estimation of the 90Y microspheres biodistribution, which is not always the case. Due to the growing interest in theragnostic dosimetry for personalized radionuclide therapy, a robust relationship between the delivered and pre-treatment radiation doses is required. In this work, we aim to investigate the predictive value of absorbed dose metrics calculated from 99mTc-MAA (simulation) compared to those obtained from 90Y post-therapy SPECT/CT.Results A total of 79 patients were analyzed. Pre- and post-therapy 3D-voxel dosimetry was calculated on 99mTc-MAA and 90Y SPECT/CT, respectively, based on Local Deposition Method (LDM). Mean absorbed dose, tumor-to-normal ratio, and dose distribution in terms of dose-volume histogram (DVH) metrics were obtained and compared for each volume of interest (VOIs). Mann-Whitney U-test and Pearson’s correlation coefficient was used to assess the correlation between both methods. The effect of the tumoral liver volume on the absorbed dose metrics was also investigated. Strong correlation was found between simulation and therapy mean absorbed doses for all VOIs, although simulation tended to overestimate tumor absorbed doses by 26%. DVH metrics showed good correlation too, but significant differences were found for several metrics, mostly on non-tumoral liver. It was observed that the tumoral liver volume does not significantly affect the differences between simulation and therapy absorbed dose metrics.Conclusion This study supports the strong correlation between absorbed dose metrics from simulation and therapy dosimetry based on 90Y SPECT/CT, highlighting the predictive ability of 99mTc-MAA, not only in terms of mean absorbed dose but also of the dose distribution.
Sodium Butyrate Alleviates Neuroinflammation in Fluorosis Mice by Suppressing NF-κB Signaling
Authors: Jiang Tao , Sun Jinghua , Xu Lingling , Li Rui , Lu Kemou , Qu Xiaona , Cheng Ye , Zhang Yang , He Hongmei 
Published: May 2023

AbstractObjective:Excessive fluoride intake results in fluorosis, which is responsible for skeletal fluorosis and neuroinflammation. Fluoride activates microglia in the central nervous system to release inflammatory factors that exaggerate nerve injury. Sodium butyrate (NaB) has the potential to regulate the immune response; however, its function in fluorosis still needs to be clarified.Methods:This study involved the development of an animal model of chronic fluorosis, which was then treated with NaB.We evaluated animal activities, pathological features, and inflammation-associated signaling pathways in vivo and considered cell viability and inflammatory signaling in vitro.Results:The results revealed that NaB treatment induced a reliable preventative effect on fluorosis in mice based on restored learning and memory, decreased intranuclear NF-κB signaling, and inflammatory factors. Additionally, 0.2 mM NaB restored cell viability and corrected the elevated inflammatory signaling in BV-2 cells under sodium fluoride stress.Conclusion:NaB can alleviate fluorosis by suppressing NF-κB signaling and inflammasomes, providing a reliable method for the treatment of clinical fluorosis.
Mediating Effect of Self-management on Health Empowerment and Quality of Life of Elderly Comorbid Patients
Authors: Wu Lanxin , Zhang Yan , Meng Lixue , Liu Li , Zhao Ting 
Published: May 2023

Abstract
Background
Under the general trend of global aging, comorbidity among the elderly is becoming more and more common, which may have a certain impact on the quality of life of the elder. There is evidence that self-management and health empowerment are positively correlated with quality of life. However, limited research has explored the potential mechanism among them. Therefore, the purpose of this study is to explore the interaction path and mechanism among health empowerment, self-management and quality of life of elderly comorbid patients, and to provide theoretical basis for formulating intervention programs to improve their quality of life in the later stage.
Objective
To explore the relationship among health empowerment, self-management and quality of life of elderly patients with comorbidity.
Methods
309 elderly patients with comorbidity in Zhengzhou City, Henan Province were investigated by questionnaire, including Health Empowerment Scale, Chronic Disease Self-management Scale and SF-12 Scale.
Results
The score of health empowerment, self-management and quality of life of the elderly patients with comorbidity were (92.18±8.917), (136.58±12.42) and (89.30±8.72) respectively. Health empowerment, self-management and quality of life of elderly patients with comorbidity were positively correlated (P < 0.01). The direct effect of health empowerment on quality of life is 0.493, the indirect effect is 0.207, the total effect is 0.724, and the intermediary effect accounts for 28.75% of the total effect. Self-management plays a partial intermediary role between health empowerment and quality of life.
Conclusion
The health empowerment, self-management and quality of life of elderly comorbid patients need to be further improved. The self-management of elderly comorbid patients plays a partial intermediary role between health empowerment and quality of life, and the quality of life of patients can be effectively improved by improving their health empowerment and self-management ability.
A Preliminary Study of Wall Shear Stress in Carotid Artery Stenting
Authors: Xiaoyong Tao , Yuping Chen , Wei Huang , Juan Chen , Zhuo Li , Feng Qiu 
Published: May 2023

Abstract
Objective: To characterize carotid wall shear stress (WSS)following carotid artery stenting (CAS) in patients with carotid stenosis.
Methods: Twenty-eight patients with carotid stenosis treated with CAS between March 2021 to May 2022 in the eighth medical center of the PLA General Hospital were selected for our study. Carotid ultrasound was performed before the operation, one week post-operation, and six months post-operation. Carotid artery WSS was detected by blood flow vector imaging, and the changes in WSS before and after the operation were collected. Genetic testing of drugs was detected for patients with restenosis.
Results: Pre-operative WSS of the proximal, narrowest region, and distal carotid arteries in patients with ischemic carotid artery stenosis was 7.88±3.18Pa, 14.36±6.66Pa, and 1.55±1.15Pa, respectively. Comparatively, pre-operative WSS of the proximal, narrowest region and distal carotid arteries in patients without ischemic symptoms was 5.02±1.99Pa, 9.68±4.23Pa, and 1.10±0.68Pa, respectively, with a significant difference between the two groups (p<0.001). Overall WSSof the proximal, narrowest region, and distal carotid arteries in patients before CAS was 6.68±3.0Pa, 12.47±5.98Pa, and 1.39±0. 96Pa. WSS of the proximal, narrowest region, and distal carotid was 4.15±1.42Pa, 6.71±2.64Pa, and1.86±1.13Pa one week after CAS, compared to 4.44±1.91Pa, 7.90±4.38Pa, and 2. 36±1.09Pa six months after CAS. WSS of the proximal and narrowest region of the carotid artery was reduced after carotid stenting, and the difference was statistically significant (p<0.001). There was no statistically significant difference in WSS between one week and six months after stenting (P > 0.05).
Conclusion: Changes in carotid WSS are closely related to carotid stenosis, which can provide important hemodynamic information for the treatment of CAS. The technique has important application value in pre-operative evaluation, curative effect evaluation, and long-term follow-up.