bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in the implementation of preventive treatment for tuberculosis in people living with HIV/Aids: A qualitative study
Authors: Reis Vânia Silva dos , Nascimento Débora Dupas Gonçalves do , Silva Terezinha Alcântara da , Paniago Anamaria Mello Miranda , Negri Adriana Carla Garcia , Ferreira Gabriela , Ferreira Rafaela , Lemos Everton Ferreira , Trajman Anete , Oliveira Sandra Maria do Valle Leone de 
Published: September 2023

AbstractTreatment of tuberculosis infection (TBI) in people living with HIV/Aids (PLWHA) reduces the risk of tuberculosis disease (TBD), the main cause of death in this population. Recognizing the barriers related to the scale up of tuberculosis preventive treatment (TPT) can contribute to reorganization of health services for achieving TB elimination. This qualitative study aimed to understand the perception of specialized care health professionals of a capital city in Brazil about TPT for PLWHA. Between October 2020 and August 2022 ten physicians and four nurses working for more than six months in reference HIV/Aids services were interviewed. Interviews were guided by a script of previously validated, semi-structured questions. The audios were recorded, transcribed, and categorized based on Grounded Theory, and its analysis was anchored in the theoretical framework of Symbolic Interactionism. Sampling was performed using theoretical saturation. The emerged central phenomenon “Facing challenges in the implementation of TPT in the light of scientific evidence” was supported by four categories:1) Demonstrating theoretical knowledge regarding TBI and its treatment guidelines; 2) Dealing with the complexities of guidelines adherence in the routine service; 3) Building bonds to overcome different challenges in the care of PLWHA; 4) Seeking strategies to facilitate adherence to the TPT guidelines service. Professionals faced challenges in implementing TPT due to structural obstacles in service, hesitation in establishing therapy, and the risk of adverse events when dealing with patients’ vulnerabilities, despite available scientific evidence, theoretical knowledge, and guidelines recommendations. They envisaged ideal conditions to adhere to the TPT guidelines in service, and seeked to mediate confrontations by strengthening their bond with patients through multidisciplinary interaction, teaching, and research.
Prevalence and Risk Factors of Hypertension among Patients with Opioid Use Disorder in Methadone Maintenance Treatment
Authors: Sason Anat , Adelson Miriam , Schreiber Shaul , Peles Einat 
Published: September 2023

AbstractBACKGROUNDThe current prevalence of hypertension (HTN) and risk factors that characterize its occurrence during long-term methadone maintenance treatment (MMT) have not been established.METHODSHTN was defined if either systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥90 mmHg was detected twice (one week apart) among adult MMT patients. Recorded and current body mass index (BMI), BP, methadone dose and serum level, and drugs in urine were analyzed. Data on socioeconomic and addiction history characteristics were also retrieved.RESULTSHTN was detected in 103 (35.4%) of the 291 study patients (age range 26-81 years, 62 females). The HTN and non-HTN groups were comparable in sex (P=0.3), age (56.6±9.6 vs. 55.3±9.7 years,P=0.3), and duration in MMT (13.0±9.1 vs. 12.5±8.6 years,P=0.7). Age correlated linearly with duration in MMT (R=0.3,P<0.001) and with systolic BP (R=0.27,P<0.001). Patients with HTN had higher BMI values than those without HTN (28.1±5.4 vs. 25.5±5.2, respectively,P<0.001) and fewer had positive urine test findings to any substance (35.7% vs. 50.5%,P=0.01). Comparison of first methadone serum, BP, and BMI levels 11.9±5.8 years earlier increased more for the HTN group, independent of methadone dose and serum levels that lowered significantly over time. Drug abuse and older age were not associated with increased BMI and BP.CONCLUSIONWeight gain was associated with BP elevation and characterized patients who succeeded in drug abstinence during MMT.PERSPECTIVESIdentifying HTN and offering treatment for this highly prevalent life-threatening condition among older patients in MMT is recommended.
Provision of professional interpreters and Heart School attendance for foreign-born compared with native-born myocardial infarction patients in Sweden
Authors: Zwackman Sammy , Leosdottir Margret , Hagström Emil , Jernberg Tomas , Karlsson Jan-Erik , Lawesson Sofia Sederholm , Michelsen Halldora Ögmundsdottir , Ravn-Fischer Annica , Wallert John , Alfredsson Joakim 
Published: September 2023

AbstractBackground and aimsInteractive patient education, referred to as Heart School (HS), is an important part of cardiac rehabilitation (CR) after myocardial infarction (MI), which has been associated with improved outcomes. Little is known about HS attendance among foreign-born patients. The aims were to assess; 1) HS attendance in foreign-born versus native-born patients, 2) the association between the provision of professional interpreters and HS attendance, and 3) secondary prevention goal attainment after MI based on HS attendance.MethodsThe provision of professional interpreters during post-MI follow-up was assessed by a questionnaire sent to all 78 Swedish CR sites. Patient-specific data was retrieved from the SWEDEHEART registry. The association between provision of professional interpreters and HS attendance was estimated with logistic regression models. HS attendance and attainment of secondary prevention goals by country of birth were investigated.ResultsIn total, 8377 patients <75 years (78% male) were included. Foreign-born (19.8%) had higher prevalence of cardiovascular risk factors and were less likely to attend HS (33.7 vs 51.3%, p<0.001), adjusted odds ratio (OR) 0.59 (95% confidence interval (CI) 0.52-0.68), compared with native-born patients. CR centers providing professional interpreters had higher HS attendance among foreign-born (adjusted OR 1.55, 95% CI 1.20-2.01) but not among native-born patients. Attending HS was similarly associated with improved secondary prevention goal attainment in both groups.ConclusionDespite similar positive association between HS attendance and attainment of secondary prevention goals, foreign-born patients attended HS less often. With provision of professional interpreters HS attendance appears to increase in foreign-born patients.
Circulation of SARS-CoV-2 and co-infection withPlasmodium falciparumin Equatorial Guinea
Authors: López-Farfán Diana , Ncogo Policarpo , Oki Consuelo , Riloha Matilde , Ondo Valero , Cano-Jiménez Pablo , Martínez-Martínez Francisco José , Comas Iñaki , Irigoyen Nerea , Berzosa Pedro , Llanes Agustín Benito , Gómez-Díaz Elena 
Published: September 2023

AbstractThe impact of COVID-19 in Africa has been a big concern since the beginning of the pandemic. However, low incidence of COVID-19 case severity and mortality has been reported in many African countries, although data are highly heterogeneous and, in some regions, like Sub-Saharan Africa, very scarce. Many of these regions are also the cradle of endemic infectious diseases like malaria. The aim of this study was to determine the prevalence of SARS-CoV-2, the diversity and origin of circulating variants as well as the frequency of co-infections with malaria in Equatorial Guinea. For this purpose, we conducted antigen diagnostic tests for SARS-CoV-2, and microscopy examinations for malaria of 1,556 volunteers at six health centres in Bioko and Bata from June to October 2021. Nasopharyngeal swab samples were also taken for molecular detection of SARS-COV-2 by RT-qPCR and whole genome viral sequencing. We report 3.0% of SARS-CoV-2 and 24.4% of malaria prevalence over the sampling in Equatorial Guinea. SARS-CoV-2 cases were found at a similar frequency in all age groups, whereas the age groups most frequently affected by malaria were children (36.8% [95% CI 30.9-42.7]) and teenagers (34.7% [95% CI 29.5-39.9]). We found six cases of confirmed co-infection of malaria and SARS-CoV-2 distributed among all age groups, representing a 0.4% frequency of co-infection in the whole sampled population. Interestingly, the majority of malaria and SARS-CoV-2 co-infections were mild. We obtained the genome sequences of 43 SARS-CoV-2 isolates, most of which belong to the lineage Delta (AY.43) and that according to our pandemic-scale phylogenies were introduced from Europe in multiple occasions (7 transmission groups and 17 unique introductions). This study is relevant in providing first-time estimates of the actual prevalence of SARS-CoV-2 in this malaria-endemic country, with the identification of circulating variants, their origin, and the occurrence of SARS-CoV-2 and malaria co-infection.
Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions inDrosophila
Authors: Suito Takuto , Nagao Kohjiro , Deng Xiangmei , Ganser Christian , Uchihashi Takayuki , Tsutsumi Motosuke , Nemoto Tomomi , Hara Yuji , Tominaga Makoto , Sokabe Takaaki 
Published: September 2023

ABSTRACTTransient receptor potential (TRP) and PIEZO channels are known receptors for physical stimuli such as temperature and mechanical touch in sensory nerves. Since these receptors are localized in the plasma membrane, the regulation of sensory receptor activity by plasma membrane lipids has recently attracted attention. In this study, we focused on ether phospholipids (ePLs), which are abundant in neurons, and analyzed their role in somatosensation usingDrosophilaas a model. Reduced warmth avoidance was observed with ePL synthesizing gene knockout or knockdown in warmth-sensitive TRPA1-expressing neurons. The temperature threshold forDrosophilaTRPA1 channels significantly decreased in presence of ePLs. In addition, we found that ePLs modulate the mechanosensory behavior and activation properties of the mechanosensitive channel PIEZO. Finally, we revealed that ePLs affect physicochemical properties of the plasma membrane, such as membrane tension and lipid order, in culture cells. Our study identified ePLs as crucial regulators of multiple somatosensation modalities inDrosophila. Effects due to alteration of cellular membrane properties and activity modulation of sensory receptors.
Linear Mixed Model of Virus Disinfection by Chlorine to Harmonize Data Collected Across Broad Environmental Conditions
Authors: Chaplin Mira , Henderson James , Leung Kaming , Szczuka Aleksandra , Hansen Brianna , Rockey Nicole C. , Wigginton Krista 
Published: September 2023

AbstractDespite the critical importance of virus disinfection by chlorine, we lack a fundamental understanding of the relative susceptibility of different viruses to chlorine and robust quantitative relationships between virus disinfection rate constants and environmental parameters. We conducted a rapid systematic review of virus inactivation by free chlorine and used the resulting data set to develop a linear mixed model that estimates chlorine inactivation rate constants for viruses based on experimental conditions. Over 550 data points were collected in our systematic review, representing 82 viruses over a broad range of environmental conditions. The harmonized inactivation rate constants under reference conditions (pH = 7.53, T = 20 °C, [Cl-] < 50 mM) spanned 4 orders of magnitude, ranging from 0.0196 to 1150 L mg-1min-1and uncovered important trends between viruses. Whereas common surrogate bacteriophage MS2 does not serve as a conservative chlorine disinfection surrogate for many human viruses, CVB5 was one of the most resistant viruses in the dataset. The model quantifies the role of pH, temperature, and chloride levels across viruses, and an online tool allows users to predict rate constants for viruses and conditions of interest. Results from the model highlighted potential shortcomings in current USEPA disinfection guidelines.SynopsisViruses must be adequately removed by disinfection processes to protect public health. We review data on virus inactivation of chlorine to determine what concentrations of chlorine are required to remove viruses and whether current regulations are adequately protective.
Dual lineage origins of neocortical astrocytes
Authors: Zhou Jiafeng , Vitali Ilaria , Roig-Puiggros Sergi , Javed Awais , Jabaudon Denis , Mayer Christian , Bocchi Riccardo 
Published: September 2023

AbstractAstrocytes represent one of the most abundant cell types in the central nervous system, and play an essential role in nearly all aspects of brain functions1. Recent studies have challenged the notion that cortical astrocytes are a uniform population, and have highlighted their diverse characteristics at the morphological, molecular, and functional levels2-5. However, how this diversity originates and establishes during cortical development, remains largely unknown. Using single-cell RNA sequencing, we identified five distinct astrocyte subtypes displaying unique spatial patterns in the mouse neocortex, and discovered essential regulators for their formation. Furthermore, we used TrackerSeq6, a method that integrates heritable DNA barcodes into the genome of electroporated progenitors, to track clonally related astrocytes, and identified two distinct lineages that give rise to the five astrocyte subtypes. The first lineage derives from Emx1+multipotent progenitors that first generate neurons and then switch to produce cortical astrocytes. The second lineage stems from a fate-restricted progenitor population that exclusively gives rise to a specific subset of cortical astrocytes, marked by Olig2. The knockout of this gene in cortical progenitors is sufficient to promote a fate switch between the two lineages. These findings offer novel insights into the cellular mechanisms underlying astrocyte diversity, highlighting the presence of multiple progenitor subtypes, responsible for generating distinct subtypes of astrocytes.
Less cortical complexity in ventromedial prefrontal cortex is associated with a greater preference for risky and immediate rewards
Authors: Bergström Fredrik , Lerman Caryn , Kable Joseph W. 
Published: September 2023

AbstractIn our everyday lives, we are often faced with situations in which we have to make choices that involve risky or delayed rewards. However, the extent to which we are willing to accept larger risky (over smaller certain) or larger delayed (over smaller immediate) rewards vary across individuals. Here we investigated the relationship between cortical surface complexity in medial prefrontal cortex and individual differences in risky and intertemporal preferences. We found that lower cortical complexity in ventromedial prefrontal cortex (vmPFC) was associated with a greater preference for risky and immediate rewards. In addition to these common structural associations in mPFC, we also found associations between lower cortical complexity and a greater preference for immediate rewards that extended into left dorsomedial prefrontal cortex and right vmPFC. Taken together, the shared association suggests that lower cortical complexity in vmPFC may be a structural marker for individual differences in impulsive behavior.
Mouse models for pancreatic ductal adenocarcinoma are affected by the cre-driver used to promote KRASG12Dactivation
Authors: Mousavi Fatemeh , Thompson Joyce , Lau Justine , Renollet Nur , Martin Mickenzie B. , McGue Jake , Frankel Timothy , Shooshtari Parisa , Pin Christopher L. , Bednar Filip 
Published: September 2023

AbstractThe fundamental biology of pancreatic ductal adenocarcinoma has been greatly impacted by the characterization of genetically modified mouse models that allow temporal and spatial activation of oncogenic KRAS (KRASG12D). The most commonly used model involves targeted insertion of acrerecombinase into thePtf1agene. However, this approach disrupts thePtf1agene, resulting in haploinsufficiency that likely affects sensitivity to oncogenic KRAS (KRASG12D). The goal of this study was to determine ifPtf1ahaploinsufficiency affected the acinar cell response toKRASG12Dbefore and after induction of pancreatic injury. We performed morphological and molecular analysis of three mouse lines that express a tamoxifen-induciblecrerecombinase to activateKRASG12Din acinar cells of the pancreas. The cre-recombinase was targeted to the acinar-specific transcription factor genes,Ptf1aandMist1/Bhlha15, or expressed within a BAC-derivedElastasetransgene. Up to two months after tamoxifen induction ofKRASG12D, morphological changes were negligible. However, induction of pancreatic injury by cerulein resulted in stark differences in tissue morphology between lines within seven days, which were maintained for at least five weeks after injury.Ptf1acreERTpancreata showed widespread PanIN lesions and fibrosis, while theMist1creERTandEla-creERTmodels showed reduced amounts of pre-neoplastic lesions. RNA-seq analysis prior to inducing injury suggestedPtf1acreERTandMist1creERTlines have unique profiles of gene expression that predict a differential response to injury. Multiplex analysis of pancreatic tissue confirmed different inflammatory responses between the lines. These findings suggest understanding the mechanisms underlying the differential response toKRASG12Dwill help in further defining the intrinsic KRAS-driven mechanisms of neoplasia initiation.
Cross-species conservation in the regulation of parvalbumin by perineuronal nets
Authors: Wang Angela S. , Wan Xinghaoyun , Storch Daria-Salina , Cornez Gilles , Balthazart Jacques , Cisneros-Franco J. Miguel , de Villers-Sidani Etienne , Sakata Jon T. 
Published: September 2023

ABSTRACTParvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to neural processes has been studied in mammals, relatively little is known about PV function in non-mammalian species, and discerning similarities in the regulation of PV across species can provide insight into evolutionary conservation in the role of PV neurons. Here we investigated factors that affect the abundance of PV in PV neurons in sensory and motor circuits of songbirds and rodents. In particular, we examined the degree to which perineuronal nets (PNNs), extracellular matrices that preferentially surround PV neurons, modulate PV abundance as well as how the relationship between PV and PNN expression differs across brain areas and species and changes over development. We generally found that cortical PV neurons that are surrounded by PNNs (PV+PNN neurons) are more enriched with PV than PV neurons without PNNs (PV-PNN neurons) across both rodents and songbirds. Interestingly, the relationship between PV and PNN expression in the vocal portion of the basal ganglia of songbirds (Area X) differed from that in other areas, with PV+PNN neurons having lower PV expression compared to PV-PNN neurons. These relationships remained consistent across development in vocal motor circuits of the songbird brain. Finally, we discovered a causal contribution of PNNs to PV expression in songbirds because degradation of PNNs led to a diminution of PV expression in PV neurons. These findings in reveal a conserved relationship between PV and PNN expression in sensory and motor cortices and across songbirds and rodents and suggest that PV neurons could modulate plasticity and neural dynamics in similar ways across songbirds and rodents.
Vertical take-off and hover to cruise transition for a hybrid UAV using model predictive controller and MPC allocation
Authors: Mohammadi Navid , Tayefi Morteza , Zhu Man 
Published: September 2023

Purpose
Dual-thrust hybrid unmanned aerial vehicle (UAV) technology offers a highly robust and efficient system that incorporates the take-off and landing capabilities of rotary-wing aircraft with the endurance capacities of fixed-wing aircraft. The purpose of this study is to model and control a hybrid UAV in three distinct flight modes: rotary-wing, fixed-wing and over-actuated model.

Design/methodology/approach
Model predictive control (MPC) along with linear models are applied to design controllers for the rotary-wing or vertical take-off and transition to the fixed-wing flight. The MPC algorithm is implemented with two approaches, first in its usual form and then in a new form with the help of tracking error variables as state variables.

Findings
Because the tracking error variables are more compatible with the cost function used in MPC, the results improve significantly. This is especially important for a safe and stable transition from rotary-wing to fixed-wing flight, which should be done quickly. The authors also propose a control allocation strategy with MPC algorithm to exploit the thrust and control inputs of both rotary-wing and fixed-wing systems for the transition phase. As the control system is over-actuated, the proposed algorithm distributes the control signal among the actuators better than the MPC alone. The numerical results show that the flight trajectory is also improved.

Originality/value
The research background is reviewed in the introduction section. The other sections are originally developed in this paper to the best of the authors’ knowledge.
The mediating role of perceived enjoyment and attitude consistency in omni-channel retailing
Authors: Gao Mengjia , Huang Lin 
Published: September 2023

PurposeThis study considers perceived enjoyment and attitude consistency as internal states of consumers in an omni-channel environment. This study aims to investigate the mediating role of perceived enjoyment and attitude consistency to reveal how omni-channel environment factors of interaction fluency, convenience, price advantage and personalization contribute to omni-channel shopping intention.Design/methodology/approachConsumers who had shopped at Uniqlo's online and offline stores were surveyed through an online questionnaire, and 566 data were collected for analysis through partial least squares structural equation modeling (PLS-SEM).FindingsThe results find that interaction fluency, price advantage and personalization positively affect perceived enjoyment, interaction fluency and convenience positively affect attitude consistency and perceived enjoyment and attitude consistency in turn facilitate omni-channel shopping intention. The mediating role of perceived enjoyment and attitude consistency was confirmed.Originality/valueThe original finding of this study is that factors such as interaction fluency, convenience, price advantage and personalization in omni-channel retailing require momentary and continuous affective states of consumers to facilitate omni-channel shopping intention, respectively. Therefore, this study considers the necessity of capturing different affective states of consumers in omni-channel shopping.