bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid peroxidation and neuroinflammation: A possible link between maternal fructose intake and delay of acquisition of neonatal reflexes in Wistar female rats
Authors: Prado Spalm Facundo H. , Cuervo Sánchez Marié L. , Furland Natalia E. , Vallés Ana S. 
Published: July 2023

AbstractFructose is a common sweetener found in the daily diet supplemented to many processed and ultra‐processed foods and beverages. Consumption of fructose‐sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic pro‐inflammatory status, and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain function of the offspring is less explored. Therefore, the aim of this study was first, to investigate adverse effects in developmental milestones of the progeny of mothers with metabolic syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, and second to identify possible molecular changes in the nervous system of the newborns associated with maternal fructose intake. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. Changes in the developmental milestones due to maternal fructose consumption were studied (PN3–PN21) in another subgroup of offspring. Sexually dimorphic effects were found on the progeny's acquisition of neurodevelopmental milestones, in brain lipid peroxidation, neuroinflammation, and antioxidative defensive response. Our results suggest that dams’ MetS, induced by fructose intake, disrupts brain redox homeostasis in female offspring and affects sensorimotor brain circuitry which may have a translational value for studying neurodevelopmental diseases.
ZnO‐Embedded Expanded Graphite Composite Anodes with Controlled Charge Storage Mechanism Enabling Operation of Lithium‐Ion Batteries at Ultra‐Low Temperatures
Authors: Ryu Kun , Lee Michael J. , Lee Kyungbin , Lee Seung Woo 
Published: July 2023

As lithium (Li)‐ion batteries expand their applications, operating over a wide temperature range becomes increasingly important. However, the low‐temperature performance of conventional graphite anodes is severely hampered by the poor diffusion kinetics of Li ions (Li+). Here, zinc oxide (ZnO) nanoparticles are incorporated into the expanded graphite to improve Li+ diffusion kinetics, resulting in a significant improvement in low‐temperature performance. The ZnO–embedded expanded graphite anodes are investigated with different amounts of ZnO to establish the structure‐charge storage mechanism‐performance relationship with a focus on low‐temperature applications. Electrochemical analysis reveals that the ZnO–embedded expanded graphite anode with nano‐sized ZnO maintains a large portion of the diffusion‐controlled charge storage mechanism at an ultra‐low temperature of −50 °C. Due to this significantly enhanced Li+ diffusion rate, a full cell with the ZnO–embedded expanded graphite anode and a LiNi0.88Co0.09Al0.03O2 cathode delivers high capacities of 176 mAh g−1 at 20 °C and 86 mAh g−1 at −50 °C at a high rate of 1 C. The outstanding low‐temperature performance of the composite anode by improving the Li+ diffusion kinetics provides important scientific insights into the fundamental design principles of anodes for low‐temperature Li‐ion battery operation.
A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses
Authors: Ratswohl Christoph , Vázquez García Clara , Ahmad Ata ul Wakeel , Gonschior Hannes , Lebedin Mikhail , Silvis Casper Ewijn , Spatt Lisa , Gerhard Cathrin , Lehmann Martin , Sander Leif E. , Kurth Florian , Olsson Simon , de la Rosa Kathrin 
Published: July 2023

AbstractThe structure‐based design of antigens holds promise for developing vaccines with higher efficacy and improved safety profiles. We postulate that abrogation of host receptor interaction bears potential for the improvement of vaccines by preventing antigen‐induced modification of receptor function as well as the displacement or masking of the immunogen. Antigen modifications may yet destroy epitopes crucial for antibody neutralization. Here, we present a methodology that integrates deep mutational scans to identify and score SARS‐CoV‐2 receptor binding domain variants that maintain immunogenicity, but lack interaction with the widely expressed host receptor. Single point mutations were scored in silico, validated in vitro, and applied in vivo. Our top‐scoring variant receptor binding domain‐G502E prevented spike‐induced cell‐to‐cell fusion, receptor internalization, and improved neutralizing antibody responses by 3.3‐fold in rabbit immunizations. We name our strategy BIBAX for body‐inert, B‐cell‐activating vaccines, which in the future may be applied beyond SARS‐CoV‐2 for the improvement of vaccines by design.
Progress of Prussian Blue and Its Analogues as Cathode Materials for Potassium Ion Batteries
Authors: Bai Yue , YuChi Ke'er , Liu Xu , Tian Shinuo , Yang Shujie , Qian Xi , Ma Bin , Fang Minghao , Liu Yan'gai , Huang Zhaohui , Min Xin 
Published: July 2023

AbstractEnvironmental pollution and the energy crisis have promoted the development of clean energy as well as new‐generation energy storage systems. Potassium ion batteries (PIBs) have emerged as a possible alternative to lithium‐ion batteries due to their abundant reserves, low cost, and impressive electrochemical performance. However, the search for suitable cathode materials has become particularly crucial. Recently, Prussian blue (PB) has been investigated as a potential cathode material for PIBs, which has an open three‐dimensional framework to accommodate a large volume of potassium ions and adjustable composition for different applications. In this review, Prussian blue and its analogues (PBAs) and their application in PIBs were summarized detailly. We presented the composition, structure, potassium ion storage mechanism, preparation process of PBAs, and then focus on the performance optimization methods of the PBAs, including transition metal doping and conductive material adding into PBAs. Finally, the challenges as well as the outlook on the future development of PBAs were proposed for further application in this battery system.
Photoinduced Regioselective Perfluoroalkylation/Cyclization Cascade of 3‐Aza‐1,5‐Dienes: Access to Pentasubstituted 3‐Perfluoroalkyl‐1,3‐Dihydropyrrol‐2‐Ones
Authors: Yang Ruihan , Chen Danna , Lin Shiyi , Yang Xuege , Shi Lou , Chang Qiaowen , Liang Deqiang 
Published: July 2023

AbstractA visible light‐induced perfluoroalkylative cyclization of 3‐aza‐1,5‐dienes leading to pentasubstituted 1,3‐dihydropyrrole‐2‐ones is presented. The reaction is regiospecific, for the radical adds across the acrylamido moiety, whereas the enaminic double bond functions as a built‐in radical trap. It could be carried out on a 2‐gram scale, and the sunlight is a usable light source. Other virtues of the protocol include a short reaction time, a low catalyst loading, mild conditions and a broad substrate scope.
The impact of shift work on pain recognition, a robust ability among intensive care nurses
Authors: Schmidt Laura , Zabelberg Sara , Schlatter Sophie , Adams Inga , Douplat Marion , Perchet Caroline , Lilot Marc , Rey Amandine Eve , Mazza Stéphanie 
Published: July 2023

AbstractBackgroundPain empathy is essential for high‐quality of care. The cognitive ability to identify and understand the pain in others remains underexplored in the context of hospital shift work. This study aimed to observe the early subliminal ability to detect pain in other faces and to investigate pain intensity evaluations during day and night shifts.MethodsTwenty‐one nurses (31 ± 7 years, 20 women) from cardio‐paediatric intensive care participated in this study. Eighteen nurses completed all testing in the morning and evening hours, before and after the 12‐hour day and night shift. In the first test, the nurses had to decide if facial stimuli presented subliminally showed pain or not. During the second test, they consciously determined the intensity of the painful faces on a numerical scale. Sleep, sleepiness and empathy were also measured.ResultsRecognition accuracy and pain sensitivity remained stable over time, only sensitivity increased following the work shift (F(1,15) = 7.10, p = 0.018). Intensity ratings remained stable. Sleepiness at the end of the night shift was negatively correlated with accuracy (ρ = −0.51, p = 0.018) and positively correlated with prior night shifts (ρ = −0.50, p = 0.022).ConclusionThe judgement of facial pain expressions seems robust across shift types, only individual factors such as sleepiness interfere with pain recognition. Pain sensitivity may be enhanced during working hours.Significance StatementSome professions need to know how to assess pain 24/7 and a lack of sleep can disrupt the cognitive processes necessary for this assessment. Night shifts provoke a bias in pain management, and sleep deprivation, a decrease in pain evaluation. By conducting a repeated measure study in the field that applied a different paradigm (subliminal recognition of facial cues) we add evidence to the understanding of pain recognition and the impact of sleep deprivation on the early processing of pain in others.
Progress towards sustainable energy storage: A concise review
Authors: Folorunso Oladipo , Olukanmi Peter O. , Shongwe Thokozani 
Published: July 2023

AbstractIn this study, the benefits and challenges of existing energy storage systems are presented. The environmental threats and the apparent unreliability of fossil fuel energy sources necessitate the need for alternative sources of electrical power. Energy storage has been sourced from mechanical, electrical, thermal, chemical, and electrochemical systems. Perhaps, an electrochemical energy storage system, is a better option toward achieving a net zero carbon‐dioxide emission by 2050. Energy storage sources, such as: batteries and supercapacitors, can be reliably fabricated from the hybrid of polymers and two‐dimensional materials for electric vehicles, aviation, and grid load balancing applications. The performances of lithium‐ion batteries are yet to meet the requirements for high‐duty machines and devices. Graphite, the anode of lithium‐ion batteries, suffers from low capacity and high volume‐expansion, resulting in cracking and fracture of the electrodes. Herein, based on evidence from literature, this study suggests substituting graphite with polymer nanocomposite or metal‐oxide nanocomposites such as: conducting polymers, copper oxide, and graphene. This approach, giving attention to these materials' excellent electrochemical, thermal, electrical, mechanical, and redox properties, offers possible ways to overcome the limited limitations confronting lithium‐ion battery technology.
An international survey of SEEG cortical stimulation practices
Authors: Cockle Emily , Rayner Genevieve , Malpas Charles , Alpitsis Rubina , Rheims Sylvain , O'Brien Terence J , Neal Andrew 
Published: July 2023

AbstractObjectiveCortical stimulation is an important component of stereoelectroencephalography (SEEG). Despite this, there is currently no standardized approach and significant heterogeneity in the literature regarding cortical stimulation practices. Via an international survey of SEEG clinicians, we sought to examine the spectrum of cortical stimulation practices to reveal areas of consensus and variability.MethodsA 68‐item questionnaire was developed to understand cortical stimulation practices including neurostimulation parameters, interpretation of epileptogenicity, functional and cognitive assessment and subsequent surgical decisions. Multiple recruitment pathways were pursued, with the questionnaire distributed directly to 183 clinicians.ResultsResponses were received from 56 clinicians across 17 countries with experience ranging from 2 to 60 years (M = 10.73, SD = 9.44). Neurostimulation parameters varied considerably, with maximum current ranging from 3 to 10 mA (M = 5.33, SD = 2.29) for 1 Hz and from 2 to 15 mA (M = 6.54, SD = 3.68) for 50 Hz stimulation. Charge density ranged from 8 to 200 μC/cm2, with up to 43% of responders utilizing charge densities higher than recommended upper safety limits, i.e. 55 μC/cm2. North American responders reported statistically significant higher maximum current (P < 0.001) for 1 Hz stimulation and lower pulse width for 1 and 50 Hz stimulation (P = 0.008, P < 0.001, respectively) compared to European responders. All clinicians evaluated language, speech, and motor function during cortical stimulation; in contrast, 42% assessed visuospatial or visual function, 29% memory, and 13% executive function. Striking differences were reported in approaches to assessment, classification of positive sites, and surgical decisions guided by cortical stimulation. Patterns of consistency were observed for interpretation of the localizing capacity of stimulated electroclinical seizures and auras, with habitual electroclinical seizures induced by 1 Hz stimulation considered the most localizing.SignificanceSEEG cortical stimulation practices differed vastly across clinicians internationally, highlighting the need for consensus‐based clinical guidelines. In particular, an internationally standardized approach to assessment, classification, and functional prognostication will provide a common clinical and research framework for optimizing outcomes for people with drug‐resistant epilepsy.
Uncertainty in overturning of precariously balanced rocks due to basal contact
Authors: Saifullah M. Khalid , Wittich Christine E. 
Published: July 2023

AbstractPrecariously balanced rocks (PBRs) are a type of naturally occurring freestanding structure that provides valuable information to constrain seismic hazard at return periods which are important for critical facilities such as nuclear power plants and nuclear repositories. Exposure ages have been established to be in excess of 10,000–30,000 years, which is why precarious rocks are one of the only available means to validate seismic hazard associated with long return periods. One critical component for constraining seismic hazard in this way is the overturning estimate of a given precarious rock as a function of earthquake intensity. However, current state‐of‐the‐art methods for modeling the seismic response of precarious rocks involve significant sources of uncertainty. One of the main sources of uncertainty stems from the interface of the rock, which is usually occluded during surveying and assumed during modeling. Through extensive shake table testing, this study analyzes the uncertainty in the overturning response of a granite precarious rock specimen incorporating various degrees of interface contact. The results indicate that a small variation in the contact geometry could result in a substantial increase in the stability of the specimen, which is significant given the difficulty of surveying the interface of PBRs in the field. Repeatability tests indicate that the overturning demand can vary up to nearly ±50%. The probabilistic overturning responses are compared across the interface changes to bound uncertainty; and, the effect of modeling parameters, namely the contact normal stiffness, is evaluated through a parametric study and comparison with experimental results.
Affective profiles of exercise episodes are associated with maladaptive and adaptive motivations for exercise
Authors: Lampe Elizabeth W. , Presseller Emily K. , Abber Sophie R. , Sonnenblick Ross M. , Juarascio Adrienne S. , Manasse Stephanie M. 
Published: July 2023

AbstractObjectiveMaladaptive exercise (i.e., driven and/or compensatory exercise) is common in binge‐spectrum eating disorders (EDs; e.g., bulimia nervosa, binge ED) and associated with adverse treatment outcomes. Alternatively, individuals with EDs are often also engaging in adaptive exercise (e.g., for enjoyment or health improvement), and increasing adaptive exercise may decrease ED symptoms. The current study aimed to understand which exercise episodes are likely to be maladaptive/adaptive so that interventions can appropriately decrease/increase maladaptive and adaptive exercise.MethodWe used latent profile analysis (LPA) to identify pre‐exercise affective profiles of 661 exercise episodes among 84 individuals with binge‐spectrum EDs and examined associations between LPA‐identified profiles and subsequent exercise motivations using ecological momentary assessment.ResultsA two‐profile solution best fit our data: Profile 1 (n = 174), ‘positive affectivity,’ and Profile 2 (n = 487), ‘negative affectivity.’ Episodes in the ‘negative affectivity’ profile were more likely to be endorsed as both driven and intended to influence body shape/weight. Episodes in the ‘positive affectivity’ profile were more likely to be endorsed as exercising for enjoyment.ConclusionsResults support two phenotypes of exercise episodes, and differential associations of these phenotypes with adaptive and maladaptive motivations for exercise.
Regular routine aware routing in opportunistic mobile social networks
Authors: Syed Rabiya Mohamed Ali , Ramalakshmi Ramar , Naskath Jahangeer 
Published: July 2023

AbstractDue to intermittent connectivity, routing protocols in opportunistic mobile social networks (OMSN) forward messages through opportunistic contacts. Previous opportunistic routing protocols focus on the past contact history of nodes to make a forwarding decision. It was found that predicting temporally evolving contacts and communities according to different times of the day would improve the accuracy of the prediction. In this paper, a routing paradigm called RRoutine is proposed that allows message holders to exchange multiple copies of the message based on the predicted number of communities. This distribution continues until the remaining copies of the message become one. Each message holder applies either inter or intra‐community forwarding and selects a set of potential forwarders based on the prediction of future encounters in the community and an expected remaining duration between two nodes (ERIMD). The estimation of ERIMD takes into account the sequence of daily activities, the time scale of current activities, and the return time to regular meetings of the nodes. Also, unlike traditional routing, where a single forwarder is selected, a set of potential candidates is selected and prioritized according to their contact prediction, with the most likely candidate receiving the highest priority. Simulation results obtained from synthetic and real mobility data show that the proposed paper improves the performance of the system in terms of message delivery rate, throughput, and latency.
Energy‐efficient load balancing for divisible tasks on heterogeneous clusters
Authors: Zhang Yujian , Li Mingde , Tong Fei 
Published: July 2023

AbstractWith the growing power consumption of heterogeneous clusters, energy‐aware resource management has been a hot research topic recently. Among various candidate techniques, load balancing is one of the software schemes for energy optimization through mapping tasks to servers properly, especially for divisible tasks like web and database queries. However, most practical load balancing schemes are lack of energy awareness, while recent energy‐aware schemes usually have high time complexities. In this article, we present an energy‐efficient load balancing (EELB) scheme that consists of two‐phase heuristics, including server provisioning and load balancing. Based on prior knowledge of power models of servers in the cluster, the proposed scheme is able to make wise decisions on selecting power‐on servers as well as scheduling tasks to servers. To validate EELB, we conduct extensive experiments on both simulated and real‐world testbeds. Experimental results reveal that the proposed method outperforms competitors in terms of energy saving, and is more applicable to heterogeneous clusters.
Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications
Authors: Fu Lian‐Hua , Qi Chao , Sun Tuanwei , Huang Kai , Lin Jing , Huang Peng 
Published: July 2023

AbstractIn recent years, glucose oxidase (GOx) has aroused great research interest in the treatment of diseases related to abnormal glucose metabolisms like cancer and diabetes. However, as a kind of endogenous oxido‐reductase, GOx suffers from poor stability and system toxicity in vivo. In order to overcome this bottleneck, GOx is encapsulated in calcium‐based biomaterials (CaXs) such as calcium phosphate (CaP) and calcium carbonate (CaCO3) by using it as a biotemplate to simulate the natural biomineralization process. The biomineralized GOx holds improved stability and reduced side effects, due to the excellent bioactivity, biocompatibitliy, and biodegradability of CaXs. In this review, the state‐of‐the‐art studies on GOx‐mineralized CaXs are introduced with an emphasis on their application in various biomedical fields including disease diagnosis, cancer treatment, and diabetes management. The current challenges and future perspectives of GOx‐mineralized CaXs are discussed, which is expected to promote further studies on these smart GOx‐mineralized CaXs biomaterials for practical applications.
Small‐molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual‐inhibiting properties for bladder cancer treatment
Authors: Li Guoyin , Song Zewen , Ru Yi , Zhang Jing , Luo Lianxiang , Yang Wei , Wu Hao , Jin Haibao , Bao Xuanwen , Wei Di , Yan Zhao , Qu Haijing , Zhu Zheng , Xue Xiangdong , Zhou Gang 
Published: July 2023

AbstractBladder cancer (BCa) is one of the most common malignancies worldwide. Although multiple efforts have been made, the 5‐year survival rate of patients with BCa remains unchanged in recent years. Overexpression of the epidermal growth factor receptor (EGFR) is found in ≈74% of BCa tissue specimens; however, current EGFR‐based targeted therapies show little benefit for BCa patients, as the EGFR downstream pathways appear to be circumvented by other receptor tyrosine kinases (RTKs). In this study, two natural products are identified, namely triptolide (TPL) and hesperidin (HSP), that target and inhibit the EGFR and its downstream PI3K/AKT pathway in BCa. To synergistically combine triptolide and hesperidin, a succinic acid linker was employed to conjugate them and formed an amphiphilic TPL‐HSP EGFR‐targeting prodrug (THE), which further self‐assembled to generate nanoparticles (THE NPs). These NPs allowed the EGFR‐targeted delivery of the triptolide and hesperidin, and simultaneous inhibition of the EGFR and PI3K/AKT both in vitro and in vivo. This study provides a promising EGFR‐targeted delivery approach with the dual inhibition of the EGFR and PI3K/AKT, while also exhibiting a high drug loading and low toxicity. Our formulation may be a suitable option to deliver natural products for BCa treatment by EGFR‐targeted therapy.