bluuebunny/crossref_metadata_2025_split huggingface dataset:
First serological evidence of SARS-CoV-2 natural infection in small ruminants
Authors: Fusco Giovanna , Cardillo Lorena , Levante Martina , Brandi Sergio , Picazio Gerardo , Napoletano Michele , Martucciello Alessandra , Fiorito Filomena , De Carlo Esterina , de Martinis Claudio 
Published: January 2023

AbstractSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late December 2019 and spread worldwide, quickly becoming a pandemic. This zoonotic coronavirus shows a broad host range, including wildlife and domestic animals. Small ruminants are shown to be susceptible to SARS-CoV-2 but, to date, no natural infection has been reported. Herein, we performed a survey for SARS-CoV-2 among sheep and goats in the Campania region of Italy using an indirect multispecies ELISA. Next, positive sera were submitted to virus serum neutralization for the quantification of specific neutralizing antibodies. Out of 612 sheep and goats, 23 were found ELISA positive (3.75%) and 1 of them showed 1:20 neutralizing antibodies titer. No significant difference was found between the two species, as well as between male and female, geographical location and age. Our findings demonstrate that natural infection can occur in flocks in a field situation. Moreover, low susceptibility to SARS-CoV-2 is reported for sheep and goats, nevertheless, the continuous mutations of this virus open new scenarios on viral host range and tropism, highlighting the importance of investigating animal species that could represent ongoing or future possible hosts.
The Specter of Automation
Authors: Biondi Zachary 
Published: January 2023

AbstractKarl Marx took technological development to be the heart of capitalism’s drive and, ultimately, its undoing. Machines are initially engineered to perform functions that otherwise would be performed by human workers. The economic logic pushed to its limits leads to the prospect of full automation: a world in which all labor required to meet human needs is superseded and performed by machines. To explore the future of automation, the paper considers a specific point of resemblance between human beings and machines: intelligence. Examining the development of machine intelligence through the Marxist concepts of alienation and reification reveals a tension between certain technophilic post-labor visions and the reality of capitalistic development oriented towards intelligent technology. If the prospect of a post-labor world depends on technologies that closely resemble humans, the world can no longer be described as post-labor. The tension has implications for the potential moral status of machines and the possibility of full automation. The paper considers these implications by outlining four possible futures of automation.
Online Gaming Addiction and Basic Psychological Needs Among Adolescents: The Mediating Roles of Meaning in Life and Responsibility
Authors: Kaya Alican , Türk Nuri , Batmaz Hasan , Griffiths Mark D. 
Published: January 2023

AbstractIndividuals whose basic needs are naturally satisfied are much less dependent on their environment and more autonomous. Basic psychological needs (i.e., the general motivators of human actions) are significant predictors of online gaming addiction. Moreover, it has been posited that meaning and responsibility in life are at the center of life from an existential point of view. Therefore, a hypothetical model was tested to examine the relationships between basic psychological needs (autonomy, competence, relatedness), online gaming addiction, responsibility, and meaning in life. Data were collected from a sample of 546 participants. Mediation analysis was conducted, and the results indicated that basic psychological needs, online gaming addiction, responsibility, and meaning in life had significant negative and positive relationships. The findings indicated that responsibility and meaning in life had a serial mediating effect in the relationship between basic psychological needs and online gaming addiction. The findings also showed that the inverse relationship between online gaming addiction and basic psychological needs was at least partially explained by meaning in life and responsibility. The results of the present study are of great importance and suggest that interventions to satisfy the basic psychological needs of adolescents may help prevent online gaming addiction.
Systemic cascades on inhomogeneous random financial networks
Authors: Hurd T. R. 
Published: January 2023

AbstractThis article presents a model of the financial system as an inhomogeneous random financial network (IRFN) withNnodes that represent different types of institutions such as banks or funds and directed weighted edges that signify counterparty relationships between nodes. The onset of a systemic crisis is triggered by a large exogenous shock to banks’ balance sheets. Their behavioural response is modelled by a cascade mechanism that tracks the propagation of damaging shocks and possible amplification of the crisis, and leads the system to a cascade equilibrium. The mathematical properties of the stochastic framework are investigated for the first time in a generalization of the Eisenberg–Noe solvency cascade mechanism that accounts for fractional bankruptcy charges. New results include verification of a “tree independent cascade property” of the solvency cascade mechanism, and culminate in an explicit recursive stochastic solvency cascade mapping conjectured to hold in the limit as the number of banksNgoes to infinity. It is shown how this cascade mapping can be computed numerically, leading to a rich picture of the systemic crisis as it evolves toward the cascade equilibrium.
Screen Time from Adolescence to Adulthood and Cardiometabolic Disease: a Prospective Cohort Study
Authors: Nagata Jason M. , Lee Christopher M. , Lin Feng , Ganson Kyle T. , Pettee Gabriel Kelley , Testa Alexander , Jackson Dylan B. , Dooley Erin E. , Gooding Holly C. , Vittinghoff Eric 
Published: January 2023

Abstract
Background
Previous studies have analyzed the relationship between screen time and cardiometabolic disease risk factors among adolescents, but few have examined the longitudinal effects of screen time on cardiometabolic health into adulthood using nationally representative data.

Objective
To determine prospective associations between screen time and later cardiometabolic disease over a 24-year period using a nationally representative adolescent cohort.

Design
Longitudinal prospective cohort data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) collected from 1994 to 2018.

Participants
Adolescents aged 11–18 years old at baseline (1994–1995) followed for 24 years.

Main Measures
Predictors: screen time (five repeated measures of self-reported television and video watching from adolescence to adulthood). Outcomes: Five repeated measures of body mass index (BMI); two repeated measures of waist circumference, hypertension, hyperlipidemia, and diabetes collected at 15- and 24-year follow-up exams.

Key Results
For the 7105 adolescents in the sample (49.7% female, 35.0% non-white), the baseline adolescent average screen time per day was 2.86 ± 0.08 hours per day, which generally declined through 24-year follow-up. Average BMI at baseline was 22.57 ± 0.13 kg/m2, which increased to 30.27 ± 0.18 kg/m2 through follow-up. By 24-year follow-up, 43.4% of participants had obesity, 8.4% had diabetes, 31.8% had hypertension, and 14.9% had hyperlipidemia. In mixed-effects generalized linear models, each additional hour of screen time per day was associated with 0.06 (95% CI 0.04–0.09) within-person increase in BMI. Each additional hour of screen time per day was associated with higher within-person odds of high waist circumference (AOR 1.17, 95% CI 1.09–1.26), obesity (AOR 1.09, 95% CI 1.03–1.15), and diabetes (AOR 1.17, 95% CI 1.07–1.28). Screen time was not significantly associated with hypertension or hyperlipidemia.

Conclusions
In this prospective cohort study, higher screen time in adolescence was associated with higher odds of select indicators of cardiometabolic disease in adulthood.
Einflussfaktoren auf inklusionsbezogene Einstellungen von Lehrkräften an berufsbildenden Schulen. Ergebnisse einer empirischen Studie in deutschen Bundesländern
Authors: Burda-Zoyke Andrea , Jahn Robert W. , Driebe Thomas , Götzl Mathias 
Published: January 2023

ZusammenfassungDie inklusionsbezogenen Einstellungen von Lehrkräften gelten als wesentliche Prädiktoren für deren pädagogisches und inklusionsbezogenes Wahrnehmen und Handeln sowie den Erfolg (inklusiven) Unterrichts. In zahlreichen Studien wurden die Einstellungen von (angehenden) Lehrkräften sowie potenzielle Einflussfaktoren darauf untersucht. Unberücksichtigt blieben jedoch bisher weitgehend die Lehrkräfte an beruflichen Schulen. Daher geht die vorliegende Studie der Frage nach, welche Ausprägungen inklusionsbezogener Einstellungen bei Lehrkräften an beruflichen Schulen in Deutschland vorliegen. Zudem wird die Frage verfolgt, welche Zusammenhänge sich bei ihnen zwischen den Einstellungen zu Inklusion und potenziellen Einflussfaktoren zeigen. Unter Einsatz eines standardisierten Fragebogens, der punktuell um offene Fragen ergänzt wurde, wurden 662 Lehrkräfte an beruflichen Schulen in vier Bundesländern Deutschlands (Hamburg, Sachsen-Anhalt, Schleswig-Holstein, Thüringen) befragt. Die Einstellungen zur Inklusion fallen insgesamt neutral aus. Mittels linearer Regressionsanalyse kann gezeigt werden, dass berufliche und private Erfahrungen mit Menschen mit besonderen Bedürfnissen, Erfahrungen in inklusiven Klassen und die inklusionsbezogene Qualifizierung einen signifikanten Einfluss auf die persönliche Bereitschaft als eine Dimension der Einstellungen haben. Zudem zeigen die allgemeine und in besonderer Weise die inklusionsbezogene Selbstwirksamkeit einen positiven Effekt auf die Einstellungen. Des Weiteren zeigt sich, dass das Lehr-Lernverständnis einen Einfluss auf die Einstellungen zur Inklusion allgemein hat (ein instruktional orientiertes Verständnis hängt mit negativeren Einstellungen zusammen) und dass das Inklusionsverständnis der Lehrkräfte mit der persönlichen Bereitschaft zusammenhängt. Vor dem Hintergrund dieser Studie scheinen inklusionsbezogene Fortbildungen zur Erhöhung inklusionsbezogener Einstellungen sowie die Verbesserung von Ressourcen und Rahmenbedingungen besonders erfolgversprechend für die Umsetzung von Inklusion zu sein.
Calcium-Deficit Diet Improves Iron Content in Ovariectomized Rats
Authors: Suliburska Joanna , Wawrzyniak Natalia , Gramza-Michałowska Anna , Kurzawa Paweł 
Published: January 2023

AbstractIn women, menopause is associated with disorders related to calcium and iron content, which may increase the risk of osteoporosis. This study aimed to determine the effect of calcium deficiency on the iron content in ovariectomized rats. This study included 30 3-month-old female rats, which were divided into three groups: group C (n = 10)—control group fed the standard diet; group O—ovariectomized rats fed the standard diet; and group D—ovariectomized rats fed the calcium-deficit diet. After 3 months of experimental intervention, the weight of the rats was measured, and blood and tissue samples were collected. Morphological parameters were analyzed in whole blood, and serum levels of leptin, estrogen and C-reactive protein, and total antioxidant status were determined. The iron content was measured in tissues, and histological analysis was performed in the femur. The results obtained demonstrated that ovariectomy significantly decreased the iron content in bones, hair, spleen, liver, and kidneys. The calcium-deficit diet increased the iron content in tissues and the hemoglobin level in ovariectomized rats and also enhanced the number of osteoblasts in bones compared with the O group. In conclusion, calcium deficiency improved the iron content in ovariectomized rats in this 12-week study.
A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor, and donor lymphocyte infusion for relapsed acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation
Authors: Wei Yan , Wang Lijun , Zhu Chengying , Li Honghua , Bo Jian , Zhang Ran , Lu Ning , Wu Yongli , Gao Xiaoning , Dou Liping , Liu Daihong , Gao Chunji 
Published: January 2023

AbstractChemotherapy followed by donor lymphocyte infusion (DLI) is a promising treatment for relapsed acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the best strategy for administering this therapy is still unclear. This study sought to explore the efficacy and safety of chidamide and CAG (cytarabine, aclarubicin, and granulocyte colony-stimulating factor) (CCAG) regimen followed by DLI in relapsed AML/MDS after allo-HSCT. This was a single-arm, phase II trial in patients with relapsed AML/MDS after allo-HSCT. CCAG regimen followed by DLI was given according to the inclusion and exclusion criteria. Twenty adult patients were enrolled. The median follow-up time was 12 months. The complete remission (CR) rate was 45% and the partial remission (PR) rate was 5%. The 1-year overall survival (OS) was 56.7% (95% confidence interval (95% CI), 31.6–75.6%), and the median OS was 19 months. The 1-year relapse-free survival (RFS) was 83.3% (95% CI, 27.3–97.5%). Patients relapsing more than 6 months after HSCT and achieving CR/PR after CCAG plus DLI regimen attained significantly higher survival rates. The cumulative incidence of grade III–IV acute graft-versus-host disease (aGVHD) was 9.4%. There was no treatment-related mortality (TRM). These data suggest that CCAG plus DLI regimen is safe and induces durable remission and superior survival in patients with relapsed AML/MDS after allo-HSCT. Trial registration number: ChiCTR.org identifier: ChiCTR1800017740 and date of registration: August 12, 2018.
SRC-3/TRAF4 facilitates ovarian cancer development by activating the PI3K/AKT signaling pathway
Authors: Wang Ying , Luo Xia , Wu Nayiyuan , Liao Qianjin , Wang Jing 
Published: January 2023

Abstract
Objective
Ovarian cancer is the seventh most common cancer in women, and it causes many deaths in women worldwide. Patients with ovarian cancer have a poor prognosis and low survival rate. This study aimed to explore the role of the SRC-3/TRAF4/PI3K/AKT pathway in ovarian cancer development.

Methods
SRC-3 and TRAF4 expression in ovarian cancer cell lines were assessed using qRT-PCR and western-blotting. The expression of SRC-3 and TRAF4 in ovarian cancer cells was downregulated by transient transfection with sh-RNAs. An MTT assay was performed to evaluate cell proliferation. Cell migration and invasion were measured using a Transwell assay. Cell stemness was detected using a cell spheroidization assay and western blotting. The expression levels of stem cell factors and PI3K/AKT pathway proteins were determined by qRT-PCR and western blot analysis.

Results
SRC-3 and TRAF4 were upregulated in ovarian cancer cell lines. TRAF4 is a downstream factor of SRC-3, and the protein level of TRAF4 was regulated by SRC-3. SRC-3 knockdown reduced TRAF4 expression. Silencing SRC-3 or TRAF4 inhibited cell proliferation, migration, and invasion, as well as the expression of stem cell factors. Furthermore, sh-TRAF4 as well as treatment with LY294002, the PI3K/Akt inhibitor, inhibited the phosphorylation of Akt and PI3K, thus repressing the activation of PI3K/AKT signaling pathway in ovarian cancer cell lines. However, TRAF4 overexpression reversed the effect of SRC-3 silencing on cell proliferation, migration, invasion, and stemness.

Conclusion
Our study demonstrated that SRC-3/TRAF4 promotes ovarian cancer cell growth, migration, invasion, and stemness by activating the PI3K/AKT pathway.
Essential news for clinical practice—thyroid cancer
Authors: Kiesewetter Barbara , Wolff Ladislaia , Raderer Markus 
Published: January 2023

SummaryEstablished systemic treatment options for advanced thyroid cancer include the multityrosine kinase inhibitors lenvatinib and sorafenib for radioactive iodine refractory differentiated thyroid cancer (DTC) and vandetanib and cabozantinib for medullary thyroid cancer (MTC). Recently, the COSMIC-311 study resulted in approval of cabozantinib for DTC with progression upon lenvatinib and/or sorafenib; thus, for the first time a specific second-line therapy has been defined for these patients. In addition, the therapeutic landscape of thyroid cancer has been expanded by targeted therapies based on molecular tumor profiles. Selective RET inhibitors such as selpercatinib and pralsetinib show high activity in DTC with RET fusions and MTC with RET mutations, respectively. Further targeted treatment options include NTRK inhibitors for thyroid cancers with NTRK fusions and BRAF-targeted therapy for BRAF V600E-mutated (anaplastic) thyroid cancer.
Pubic Accessory Scrotum: a Case Report of a Rare Position
Authors: Elghazeery Mohamed Ahmed , Soliman Ashraf Saad Mohamed 
Published: January 2023

Abstract
Scrotum shows multiple congenital anomalies which could be explained by embryological abnormalities in migration of labioscrotal swelling. Our case was a neonate who had an accessory scrotum in the pubic area at delivery which is a rare position. Ultrasound scan and voiding cystourethrography showed adequate capacity, shouldering and smooth outline with insignificant mild residual urine of bladder, and dilated posterior urethra. Magnetic resonance imaging revealed a pubic accessory scrotum with thickened skin and subcutaneous tissue with no detectable internal contents or pelvic connection; however, pelvicalyceal system was dilated suggesting pelviureteric junction obstruction. Excision of accessory scrotum was discussed with parents but they refused. Ultrasound follow-up of the associated congenital hydronephrosis revealed improvement of hydronephosis.
Smart Manufacturing as a Management Strategy to Achieve Sustainable Competitiveness
Authors: Ejaz Muhammad Rahim 
Published: January 2023

AbstractThe aim of this study is to determine whether smart technologies can bring sustainable competitiveness to manufacturing firms and this study attempts to determine it through theoretical linear modelling. This paper reflects on the importance of sustainable competitiveness and means of achieving sustainable competitiveness by highlighting it through analysis of scientific literature review. It explains competitiveness by the means of resources and capabilities, clustering, and public policy. This study also presents an analytical framework that interlinks Quintuple Helix model, Industry 5.0, and sustainable competitive. This study also emphasizes on a management strategy that explains how a manufacturing firm devise a strategy to obtain sustainable competitiveness. A theoretical linear model is developed that identifies digital technologies proven to be the source of manufacturing competitiveness. This work also shed light to the limitations in order to measure or determine competitiveness factor at national, regional, or firm level. For the future researchers, this study provides a baseline to develop a mechanism of measuring competitiveness based on smart technology.
Assessment of thoracic spinal curvatures in static postures using spatially tracked 3D ultrasound volumes: a proof-of-concept study
Authors: Meszaros-Beller Laura , Antico Maria , Fontanarosa Davide , Pivonka Peter 
Published: January 2023

AbstractThe assessment of spinal posture is a difficult endeavour given the lack of identifiable bony landmarks for placement of skin markers. Moreover, potentially significant soft tissue artefacts along the spine further affect the accuracy of marker-based approaches. The objective of this proof-of-concept study was to develop an experimental framework to assess spinal postures by using three-dimensional (3D) ultrasound (US) imaging. A phantom spine model immersed in water was scanned using 3D US in a neutral and two curved postures mimicking a forward flexion in the sagittal plane while the US probe was localised by three electromagnetic tracking sensors attached to the probe head. The obtained anatomical ‘coarse’ registrations were further refined using an automatic registration algorithm and validated by an experienced sonographer. Spinal landmarks were selected in the US images and validated against magnetic resonance imaging data of the same phantom through image registration. Their position was then related to the location of the tracking sensors identified in the acquired US volumes, enabling the localisation of landmarks in the global coordinate system of the tracking device. Results of this study show that localised 3D US enables US-based anatomical reconstructions comparable to clinical standards and the identification of spinal landmarks in different postures of the spine. The accuracy in sensor identification was 0.49 mm on average while the intra- and inter-observer reliability in sensor identification was strongly correlated with a maximum deviation of 0.8 mm. Mapping of landmarks had a small relative distance error of 0.21 mm (SD = ± 0.16) on average. This study implies that localised 3D US holds the potential for the assessment of full spinal posture by accurately and non-invasively localising vertebrae in space.
Zu unangenehm, zu viel Aufwand oder keine Möglichkeit? – Emotionen und Bereitschaft von Lehramtsstudierenden zur Videografie eigenen Unterrichts
Authors: Vogelsang Christoph , Pollmeier Pascal , Gockeln Theresa , Rogge Tim 
Published: January 2023

ZusammenfassungVideografien eigenen Unterrichts sind ein mögliches methodisches Werkzeug zur Förderung der professionellen Kompetenz angehender Lehrkräfte, das allerdings innerhalb der Lehramtsausbildung noch nicht breit implementiert ist. Ein möglicher Grund hierfür könnte neben organisatorischen Herausforderungen auch in einer geringen Akzeptanz von Eigenvideografien durch Lehramtsstudierende liegen. Um besser abschätzen zu können, mit welchen Voraussetzungen affektiv-emotionaler Art bei einer breiteren Implementierung im Lehramtsstudium gerechnet werden kann, wurden N = 938 Lehramtsstudierende im Masterstudium an der Universität Paderborn zu ihren Emotionen und Bereitschaften zur Arbeit mit Eigenvideografien befragt. Dabei wurde auch erfasst, wie sich diese je nach bestehenden Erfahrungen zur Arbeit mit Videografien unterscheiden. In den Ergebnissen zeigen sich kaum affektiv-emotionale Reaktionen zur Eigenvideografie, und wenn, vor allem Gefühle der Unsicherheit. Zu beachten ist, dass zwar bei gut der Hälfte der Studierenden eine eher hohe generelle Bereitschaft zur Eigenvideografie besteht, eine konkrete Intention bzw. eine konkrete Volition zur Videografie aber geringer ist. Die ca. 10 % der Studierenden mit Eigenvideografieerfahrung im Studium zeigen erwartungsgemäß höhere Bereitschaften, aber unerwartet keine signifikant positiveren Emotionen. Insgesamt verdeutlichen die Ergebnisse, dass bzgl. der Akzeptanz der Studierenden ein höheres Potenzial zur Implementation von Eigenvideografien im Studium vorliegt, als aktuell ausgeschöpft wird.