bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reasonable identification of the early recurrence time based on microvascular invasion for hepatocellular carcinoma after R0 resection: A multicenter retrospective study
Authors: Liu Zong‐Han , Chai Zong‐Tao , Feng Jin‐Kai , Hou Yu‐Chao , Zhang Xiu‐Ping , Chen Zhen‐Hua , Xiang Yan‐Jun , Guo Wei‐Xing , Shi Jie , Cheng Shu‐Qun 
Published: March 2023

AbstractBackgroundEarly and late recurrence of hepatocellular carcinoma (HCC) have different clinical outcomes, especially for those accompanied by microvascular invasion (MVI), but the definition of early recurrence remains controversial. Therefore, a reasonable identification of the early recurrence time for HCC is urgently needed.MethodsResected recurrence patients were enrolled and divided into two cohorts, one for identification of the early recurrence time and another for verification of the accuracy of the point. Univariable and multivariable Cox regression analyses were adopted to identify the prognostic factors of recurrence HCC (rHCC) and Kaplan–Meier method was applied to analyze the overall survival (OS). The appropriate cutoff value was determined by the exhaustive method using different recurrence intervals from 1 to 24 months in turn.ResultsIn total, 292 resected rHCC patients were analyzed to calculate the early recurrence interval, and another 421 resected rHCC patients with MVI were enrolled to verify the efficacy of adjuvant transarterial chemoembolization (TACE) in this recurrence interval. MVI was identified as an independent risk factor by multivariable analysis. The OS of rHCC patients without MVI is better than that of patients with MVI when the recurrence time was within 13 months, while not beyond 13 months. The verification cohort demonstrated that adjuvant TACE provided longer survival for rHCC with MVI when the recurrence time was within 13 months, while not beyond 13 months.ConclusionFor HCC patients with MVI who underwent R0 resection, 13 months may be a reasonable early recurrence time point, and within this interval, postoperative adjuvant TACE may result in longer survival compared with surgery alone.
Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis
Authors: Liu Yun , Cao Fang , Xia Fantong , Li Jie , Dong Xiaobao , Guo Yan , Zhang Jun , Zhao Qiang , Liu Yuanyuan 
Published: March 2023

AbstractMultidrug resistance (MDR) is a primary limitation of breast cancer chemotherapy. The common mechanism of MDR is various anticancer drugs can be effluxed by the cell membrane protein P‐glycoprotein (P‐gp). Here, we found that ectopic overexpression of Shc3 was detected specifically in drug‐resistant breast cancer cells, consequently reducing sensitivity to chemotherapy and promoting cell migration by mediating P‐gp expression. However, the molecular mechanism underlying the interplay between P‐gp and Shc3 in breast cancer is unknown. We reported an additional resistance mechanism involving an increase in the active form of P‐gp after Shc3 upregulation. MCF‐7/ADR and SK‐BR‐3 cells can be sensitive to doxorubicin after knockdown of Shc3. Our results indicated that the interaction between ErbB2 and EphA2 is indirect and regulated by Shc3, and also, this complex is essential for activation of the MAPK and AKT pathways. Meanwhile, Shc3 promotes ErbB2 nuclear translocation, followed by a subsequent increase of the COX2 expression through ErbB2 binding to the COX2 promoter. We further demonstrated that COX2 expression was positively correlated with P‐gp expression and the Shc3/ErbB2/COX2 axis upregulates P‐gp activity in vivo. Our results show the crucial roles of Shc3 and ErbB2 in modulating P‐gp efficacy in breast cancer cells and suggest that Shc3 inhibition may enhance the sensitivity to chemotherapeutic drugs that target oncogene addiction pathways.
Moral foundations and future pro‐environmental lifestyles choices in the Finnish population
Authors: Silfver Mia , Niva Mari , Salmivaara Laura , Vainio Annukka 
Published: March 2023

AbstractThe aim of the study was to examine citizens' perceptions of their preferred pro‐environmental lifestyle choices in the future. We examined how these choices relate to different socio‐demographic factors and moral foundations in a Finnish population survey sample (N = 1,020). Consistent with previous research, endorsing care and fairness foundations related positively to using plant‐based food and local and natural food, as well as using sustainable energy, materials, housing and transportation solutions. However, also endorsing binding moral foundations, loyalty, authority and sanctity, related positively to using local and natural food and to using an electric car or biofuels. Most pro‐environmental practices were related to being a woman, younger age and having higher education, but preferred choices differed according to living environment (urban or rural). We conclude that different pro‐environmental choices are appealing to different socio‐demographic groups with different moral views. Promoting different ways of contributing to ecologically sustainable future could be a way to reach different societal groups. In addition, re‐framing more sustainable practices, such as plant‐based diets, could contribute to such practices becoming a feasible option for more diverse groups. Individuals' preferred future lifestyles are those that align with their moral views, and therefore policymakers should embrace this (moral) diversity in the design of future policies.
Adsorption of CO2 on Activated Carbon, Fe‐Based Metal Organic Framework, ZnO, and CaO for Carbon Capture and Storage Application
Authors: Daud Nor Khonisah , Muthiyah Darshini 
Published: March 2023

AbstractActivated carbon (AC) from coconut shell, iron‐based metal organic framework (Fe‐MOF), zinc oxide (ZnO), and calcium oxide (CaO) were prepared as adsorbents for the CO2 adsorption process. The adsorption experiments were performed in a self‐designed fixed‐bed small reactor to study the influence of reaction conditions on the CO2 adsorption capacity of adsorbents. According to the findings, Fe‐MOF showed better performance in CO2 adsorption compared to the other selected adsorbents. The results were supported by the high surface area of Fe‐MOF, which was greater than that of AC, ZnO, and CaO. The optimal parameters for CO2 adsorption of all adsorbents were determined in terms of adsorbent dosage, operating pressure, and CO2 adsorption time.
Noise simulation in classification with the noisemodel R package: Applications analyzing the impact of errors with chemical data
Authors: Sáez José A. 
Published: March 2023

AbstractClassification datasets created from chemical processes can be affected by errors, which impair the accuracy of the models built. This fact highlights the importance of analyzing the robustness of classifiers against different types and levels of noise to know their behavior against potential errors. In this context, noise models have been proposed to study noise‐related phenomenology in a controlled environment, allowing errors to be introduced into the data in a supervised manner. This paper introduces thenoisemodelR package, which contains the first extensive implementation of noise models for classification datasets, proposing it as support tool to analyze the impact of errors related to chemical data. It provides 72 noise models found in the specialized literature that allow errors to be introduced in different ways in classes and attributes. Each of them is properly documented and referenced, unifying their results through a specific S3 class, which benefits from customized print, summary and plot methods. The usage of the package is illustrated through four application examples considering real‐world chemical datasets, where errors are prone to occur. The software presented will help to deepen the understanding of the problem of noisy chemical data, as well as to develop new robust algorithms and noise preprocessing methods properly adapted to different types of errors in this scenario.
Desire for children among male survivors of childhood cancer: A DCCSS LATER study
Authors: Claessens Joyce J. M. , Penson Adriaan , Bronkhorst Ewald M. , Kremer Leontien C. M. , van Dulmen‐den Broeder Eline , van der Heiden‐van der Loo Margriet , Tissing Wim J. E. , van der Pal Helena J. H. , Blijlevens Nicole M. A. , van den Heuvel‐Eibrink Marry M. , Versluys A. Birgitta , Bresters Dorine , Ronckers Cécile M. , Walraven Iris , Beerendonk Catharina C. M. , Loonen Jacqueline J. ,   Dutch LATER Study Group
Published: March 2023

AbstractBackgroundKnowledge of the desire for children among childhood cancer survivors (CCSs) is scarce. This study evaluated the desire for children in male CCSs in comparison with male siblings.MethodsA nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor Study LATER study: 1317 male CCSs and 407 male sibling controls completed a questionnaire addressing the desire for children. Logistic regression analyses were used to explore the independent association between survivorship status and the desire for children. Furthermore, additional analyses were performed to identify which cancer‐related factors were associated with the desire for children in male CCSs.ResultsAfter adjustments for the age at assessment, the percentage of men who had a desire for children was significantly lower among CCSs compared with the siblings (74% vs. 82%; odds ratio [OR], 0.61; 95% CI, 0.46–0.82; p = .001). The association between survivorship status and the desire for children was attenuated after adjustments for marital status, level of education, and employment status (OR, 0.83; 95% CI, 0.61–1.14; p = .250). The percentage of men who had an unfulfilled desire for children remained significantly higher among CCSs compared with the siblings after adjustments for sociodemographic factors (25% vs. 7%; OR, 5.14; 95% CI, 2.48–10.64; p < .001).ConclusionsThe majority of male CCSs have a desire for children. The likelihood of having to deal with an unfulfilled desire for children is 5 times higher among CCSs compared with their siblings. This insight is important for understanding the needs and experienced problems of CCSs regarding family planning and fertility issues.
A container deployment strategy for server clusters with different resource types
Authors: Ouyang Mingxue , Xi Jianqing , Bai Weihua , Li Keqin 
Published: March 2023

AbstractThe method of deploying microservices based on container technology is widely used in cloud environments. This method can realize the rapid deployment of microservices and improve the resource utilization of cloud datacenters. However, resource allocation and deployment of container‐based microservices are key issues. With the continuous growth of computing‐ and storage‐intensive services, it is necessary to consider the deployment of microservices of different business types. This study establishes a multi‐objective optimization problem model with the similarity between containers and servers, load balance of clusters, and reliability of microservice execution as the optimization objectives. An improved artificial fish swarm algorithm is proposed for the container deployment of computing‐ and storage‐intensive microservices. The comprehensive experimental results show that, compared with the existing deployment strategies, the matching degree between the container and server, cluster load balance value, service execution reliability, and other performance parameters are improved while shortening the running time of the algorithm. In addition, under the constraint of load balancing, the resource utilization of the computing and storage server clusters is improved.
Isolation of High‐Quality Total RNA from Small Animal Articular Cartilage for Next‐Generation Sequencing
Authors: Takács Roland , Póliska Szilárd , Juhász Tamás , Barna Krisztina B. , Matta Csaba 
Published: March 2023

AbstractArticular cartilage is characterized by a low density of chondrocytes surrounded by an abundant extracellular matrix (ECM) consisting of a dense mixture of collagens, proteoglycans, and glycosaminoglycans. Due to its low cellularity and high proteoglycan content, it is particularly challenging to extract high‐quality total RNA suitable for sensitive high‐throughput downstream applications such as RNA sequencing (RNA‐Seq). Available protocols for high‐quality RNA isolation from articular chondrocytes are inconsistent, resulting in suboptimal yield and compromised quality. This poses a significant difficulty in the application of RNA‐Seq to study the cartilage transcriptome. Current protocols rely either on dissociation of cartilage ECM by collagenase digestion or pulverizing cartilage using various methods prior to RNA extraction. However, protocols for cartilage processing vary significantly depending on the species and source of cartilage within the body. Protocols for isolating RNA from human or large mammal (e.g., horse or cattle) cartilage samples are available, but this is not the case for chicken cartilage, despite the species being extensively used in cartilage research. Here, we present two improved RNA isolation protocols based on pulverization of fresh articular cartilage using a cryogenic mill or on enzymatic digestion using 1.2% (w/v) collagenase II. Our protocols optimize the collection and tissue processing steps to minimize RNA degradation and enhance RNA purity. Our results show that RNA purified from chicken articular cartilage using these methods has appropriate quality for RNA‐Seq experiments. The procedure is applicable for RNA extraction from cartilage from other species such as dog, cat, sheep, and goat. The workflow for RNA‐Seq analysis is also described here. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Extraction of total RNA from pulverized chicken articular cartilageAlternate Protocol: Extraction of total RNA from collagen‐digested articular cartilageSupport Protocol: Dissection of chicken articular cartilage from the knee jointBasic Protocol 2: RNA sequencing of total RNA from chicken articular cartilage
New combined impedance‐source network inverter with high gain performance in low shoot‐through and improved quality factors
Authors: Yousefi Moghadam Farshid , Hemmati Siroos , Abbasi Vahid 
Published: March 2023

SummaryIn this paper, a new combined impedance‐source network inverter (CISI) with high voltage gain in low duty cycle is presented. With common ground between the input source and the inverter bridge and a continuous input current, the proposed converter is a suitable choice for renewable energy applications. The duty cycle of the inverter switches is low, leading to a reduction in losses and improving the efficiency. Also, due to the small duty cycle, the modulation index can be increased, and as a result, the quality of output voltages and currents is greatly improved. The proposed circuit has no switch in the input impedance network, and the number of components is reasonable compared to other works. Another advantage of the proposed converter is the low voltage stress on its capacitors and diodes. The proposed circuit is designed and tested at 180 W. The experimental results and the calculated values are close to each other, verifying the accuracy of the analysis.
Cytological and histopathological features of recurrent calcifying aponeurotic fibroma of neck in an adolescent male‐rare presentation of a rare tumour
Authors: Khera Utkarshni , Kapatia Gargi , Gupta Vikasdeep , Kaur Manjit 
Published: March 2023

AbstractCalcifying aponeurotic fibroma is a rare benign but locally aggressive soft tissue tumour. It is most commonly seen in distal extremities and very rarely seen in head and neck region. In this case report, we describe both cytological and histological features of this tumour in a young adolescent male.
Behavioral intentions assessment of a disposable e‐cigarette among adult current, former, and non‐smokers in the United States
Authors: Russell Christopher , McKinney Willie J. , Fearon Ian M. 
Published: March 2023

AbstractModeling the public health effects of e‐cigarettes requires estimates of the likelihood that different individuals and population subgroups will start using e‐cigarettes and subsequently transition to and from combustible cigarette use. To begin to generate input values for modeling efforts, this study assessed adults' behavioral intentions in relation to a disposable e‐cigarette, “BIDI® Stick.” An online questionnaire assessed intentions to try and use a BIDI® Stick regularly in 11 flavor variants among United States (U.S.) nationally representative samples of adult (21+ years) non‐smokers (n = 2284), current smokers (n = 2391), former smokers (n = 2241), and young adult (21–24 years) non‐smokers (n = 1140) of combustible cigarettes following exposure to product information and images. Current smokers rated their intentions to use a BIDI® Stick to partially or completely replace cigarettes. Positive intention to try a BIDI® Stick at least once was, for each flavor variant, highest among current smokers (22.4%–28.1%), lower among former smokers (6.0%–9.7%) and non‐smokers (3.4%–5.2%), and lowest among never‐smokers (1.0%–2.4%). Among current smokers, former smokers, and non‐smokers, trial and regular use intentions were lowest among e‐cigarette non‐users and e‐cigarette never‐users. Approximately 23.6% of current smokers reported an intention to use a BIDI® Stick in at least one flavor to completely switch from cigarettes and/or to reduce cigarette consumption. Low trial and regular use intentions suggest that U.S. adults who do not currently smoke cigarettes and/or use e‐cigarettes are unlikely to initiate use of the BIDI® Stick e‐cigarette. Trial and regular use intentions are highest among adults who currently smoke cigarettes and/or use e‐cigarettes. A moderate proportion of current smokers may try using a BIDI® Stick e‐cigarette as a partial or complete replacement for combustible cigarettes.
Phase center motion based time modulated arrays with preprocessed time schemes for selective harmonic beamforming in B5G communication systems
Authors: Chakraborty Avishek , Ram Gopi , Mandal Durbadal 
Published: March 2023

AbstractThe possibilities of achieving beamforming antenna arrays for beyond fifth generation (B5G) communication systems by controlling the inherently generated harmonic beam patterns in “time modulation” based antenna arrays, are proposed in this article. The idea of “time modulation” is to assimilate an additional dimension “time” by using high‐speed switches for synthesizing the array radiation patterns. This in turn generates an infinite number of harmonic frequency patterns apart from the main beam at the fundamental frequency. In general, harmonic frequency patterns may be regarded as wastage of power, but with proper controlling, these spatially independent patterns created at multiple harmonics can be selectively utilized for specific purposes. In this article, the lower‐order harmonic frequency patterns of “time modulated” linear arrays (TMLA) are exploited to produce simultaneous multi‐beamforming for B5G multipoint communication. The capabilities of selective harmonic frequency patterns for multi‐beamforming are mathematically verified by proposing different beamforming switching network combinations. In this regard, phase centered motion (PCM) based TMLA is examined for simultaneous, as well as, monopulse beam scanning. PCM‐based unidirectional and bidirectional beamforming patterns with optimal time schemes are proposed. The mathematical validation of preprocessed symmetric and asymmetric time schemes, as well as, the PCM‐based optimized selective harmonic multi‐beamforming radiation patterns are discussed in detail to show the effectiveness of the proposed method.
Global nutritional challenges of reformulated food: A review
Authors: Onyeaka Helen , Nwaiwu Ogueri , Obileke KeChrist , Miri Taghi , Al‐Sharify Zainab T. 
Published: March 2023

AbstractFood reformulation, the process of redesigning processed food products to make them healthier, is considered a crucial step in the fight against noncommunicable diseases. The reasons for reformulating food vary, with a common focus on reducing the levels of harmful substances, such as fats, sugars, and salts. Although this topic is broad, this review aims to shed light on the current challenges faced in the reformulation of food and to explore different approaches that can be taken to overcome these challenges. The review highlights the perception of consumer risk, the reasons for reformulating food, and the challenges involved. The review also emphasizes the importance of fortifying artisanal food processing and modifying microbial fermentation in order to meet the nutrient requirements of people in developing countries. The literature suggests that while the traditional reductionist approach remains relevant and yields quicker results, the food matrix approach, which involves engineering food microstructure, is a more complex process that may take longer to implement in developing economies. The findings of the review indicate that food reformulation policies are more likely to succeed if the private sector collaborates with or responds to the government regulatory process, and further research is conducted to establish newly developed reformulation concepts from different countries. In conclusion, food reformulation holds great promise in reducing the burden of noncommunicable diseases and improving the health of people around the world.
The burden of gastrointestinal diseases in Japan, 1990–2019, and projections for 2035
Authors: Shiratori Yasutoshi , Hutfless Susan , Rateb George , Fukuda Katsuyuki 
Published: March 2023

AbstractBackground and AimDisease burden estimation allows clinicians and policymakers to plan for future healthcare needs. Although advances have been made in gastroenterology, as Japan has an aging population, disease burden assessment is important. We aimed to report gastrointestinal disease burden in Japan since 1990 and project changes through to 2035.MethodsThis descriptive study examined the crude and age‐standardized rates of prevalence, mortality, and disability‐adjusted life years (DALYs) of 22 gastrointestinal diseases between 1990 and 2019. We used data from the Global Burden of Disease study 2019. We calculated the expected disease burden of gastrointestinal diseases by 2035 using an autoregressive integrated moving average.ResultsSince 1990, cancer has accounted for most gastrointestinal disease‐related causes of mortality and DALYs in Japan (77.1% and 71.2% in 1990, 79.2% and 73.7% in 2019, respectively). Although cancer‐associated age‐standardized mortality rates and DALYs have shown a decreasing trend, the crude rates have increased, suggesting that an aging society has a significant impact on the disease burden in Japan. Therefore, the overall gastrointestinal disease burden is expected to increase by 2035. Noncancerous chronic diseases with a high burden included cirrhosis, biliary disease, ileus, gastroesophageal reflux disorder, hernia, inflammatory bowel disease, enteric infections, and vascular intestinal disorders. In cirrhosis, the DALYs for hepatitis C decreased and the prevalence of non‐alcoholic steatohepatitis increased.ConclusionIn the super‐aging Japanese society, the burden of gastrointestinal diseases is expected to increase in the coming years. Colorectal, gastric, pancreatic, and liver cancers are the focus of early detection and treatment.