bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a biomarker signature associated with anoikis to predict prognosis and immunotherapy response in melanoma
Authors: Wu Zhixuan , Bao Jingxia , yin Mengqi 
Published: May 2023

Abstract

Background: Skin cutaneous melanoma (SKCM) is malignant cancer known for its high aggressiveness and unfavorable prognosis, particularly in advanced tumors. Anoikisis a specific pattern of programmed cell death associated with tumor regeneration, migration, and metastasis. Nevertheless, limited research has been conducted to investigate the function of anoikis in SKCM.
Methods:Anoikis-related genes (ARGs) were extracted from Genecards to identify SKCM subtypes and to explore the immune microenvironment between the different subtypes. Prognostic models of SKCM were developed by LASSO COX regression analysis. Subsequently, the predictive value of risk scores in SKCM and the association with immunotherapy were further explored. Finally, the expression of 6 ARGs involved in the model construction was detected by immunohistochemistry and PCR.
Results: This study identified 20 ARGs significantly associated with SKCM prognosis and performed disease subtype analysis of samples based on these genes, different subtypes exhibited significantly different clinical features and tumor immune microenvironment (TIME) landscapes. The risk score prognostic model was generated by further screening and identification of the six ARGs. The model exhibited a high degree of sensitivity and specificity to predict the prognosis of individuals with SKCM. These high- and low-risk populations showed different immune statuses and drug sensitivity. Further immunohistochemical and PCR experiments identified significant differential expression of the six ARGs in tumor and normal samples.
Conclusion: Anoikis-based features may serve as novel prognostic biomarkers for SKCM and may provide important new insights for survival prediction and individualized treatment development.
Human Parvovirus B19 Infections among Blood Donors in Selected Blood Centers in Ghana
Authors: Antwi-Baffour Samuel , Mensah Benjamin Tetteh , Awuni Lydia Kintampo , Armah Dorinda Naa Okailey , Annison Lawrence 
Published: May 2023

Abstract
Background Blood transfusion is an invaluable human resource and lifesaving therapy in hospital practice for patients, but it is bereft with possible transmission of infection such as Human Parvovirus B19. Human Parvovirus B19 is the only member of the Parvoviridae family known to be pathogenic to humans. Infections of Parvovirus B19 occur all year round and can affect all age groups even though a number of the patients show subclinical manifestations. The aim of this research was to determine the sero-prevalence of Human Parvovirus B19 infections among blood donors at selected blood centers in Ghana.Methods The research was a cross-sectional study carried out among blood donors at the selected blood banks. Blood samples were collected from the participants and screened for both IgG and IgM antibodies to Human Parvovirus B19 using ELISA Kits to establish the sero prevalence of the virus among the blood donors. Risk factors associated with the spread of the infections were also determined.Results A total of 167 participants took part in the study and majority of them were males (93.7%) and about70.7% of them were between the ages of 30 to 39 years. At the end of the sample analysis, 10 (5.9%) of the participants tested positive for IgM antibodies (Reactive), indicating active infections whilst 108 (64.7%) were reactive for IgG antibodies, representing those that have been exposed to the virus before. Though none of the study participants have had any blood transfusion before, about 47.3% had however donated blood before. From the demographics data gathered, the study also showed that none of the participants had multiple sex partners, used drugs, smoked or shared needles but about 22.8% had however received hepatitis B vaccination.Conclusion The outcome of the study showed that more than 50% of participants were reactive to the IgG antibodies indicating previous exposure to the virus and 5.9% were reactive to the IgM antibodies an indicator of current and active infection. These findings indicate that it may be very important to include Parvovirus screening in the procedure for blood donation in order to make blood transfusion therapy a safe process.
A Study on Student Satisfaction in Private Universities in Sri Lanka
Authors: P.M.R.H Jayasinghe , P.V.C Prasad , K.H.H.K Premarathna , M.V.B Madhumali 
Published: May 2023

Abstract
This study focusing on Student Satisfaction should generally took place within a university system, regardless of state or private. This work focused on the study of the satisfaction of students studying in private universities in Sri Lanka and how selected factors affect to satisfaction of the students. Our study investigated about the components that may had a large influence on student satisfaction, and whether there was a relationship between those factors, as well as what factors had a significant influence on student satisfaction in private universities. The main purpose of this study was to determine whether students are satisfied or not. It is intended to be done with a focus on. Based on the represented sample of 370 students studying in the top five major private universities and higher education in Sri Lanka.The Main objective of this survey was to review the perspective of students studying on private universities in Sri Lanka. Based on the data obtained and to pave the way for improvements and changes to be made in the private university system. This research highlights the importance of student satisfaction in higher education, impact of selected variables to the student satisfaction and the need to focus on improving the quality of education and services provided by the university to positively influence students’ learning experiences and academic performance. By addressing the factors that influence student satisfaction, private institutions of higher education in Sri Lanka can improve their image and reputation, and ultimately provide a more fulfilling experience to their students
Systematic Design of Phonon-Engineered Superconductors: Optimizing Electron Pairing for High-Temperature Superconductivity
Authors: Farschi Esh , Smith John , Kharakov Vladimir , Fuji Mitsuno 
Published: May 2023

Abstract
High-temperature superconductivity (HTS), occurring above 77 K, promises significant advancements in energy-efficient technologies. Despite extensive research, a comprehensive understanding of HTS remains elusive, and discovering new materials or mechanisms has been largely serendipitous. This study presents a novel explanation for HTS, focusing on manipulating phonon-mediated electron pairing through enhancing electron-phonon coupling and optimizing phonon density of states (DOS). The proposed approach provides a systematic pathway for designing materials exhibiting HTS. Experimental results confirm successful realization of HTS in a new class of materials, termed "phonon-engineered superconductors" (PESCs), offering a promising platform for future research and technological advancements.
A New Ab Initio Algorithm for Structure Prediction of Peptides, Theory, Software and Database
Authors: Ru Xiao , Yao Hanrui , Lu Haorui , Yuan Bowen , Li Zhifeng 
Published: May 2023

Abstract
We present a new fragment-based algorithm to solve the problem of structural prediction for peptide molecules using ab initio calculation. We developed an operation of multilevel ensemble assembly derived from the theory of statistical physics and adopted the structural optimization at the quantum chemistry level. A novel scheme of ensemble acquisition with higher accuracy and completeness is developed specifically for the basic units that act as the initial elements. The ensemble property of fragments at the junction is used to judge the potential of individuals of each block ensemble for construction. The test results show our algorithm is better than the scheme of structure extraction from the Protein Data Bank, which is widely used in biology. We also establish a mathematical form to describe our algorithm and generalize to a framework of a theory appropriate for structural prediction for general linear molecules. Meanwhile, the trial version of this prediction software and peptide database is published.
Straightforward Synthesis of Functionalized γ-Lactams using Impure CO2 Stream as the Carbon Source
Authors: Qin Yuman , Cauwenbergh Robin , Pradhan Suman , Maiti Rakesh , Frank Philippe , Das Shoubhik 
Published: May 2023

Abstract
Direct utilization of CO2 into organic synthesis has found enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we have described a straightforward synthetic route for the synthesis of γ-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and has been applied for the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized γ-lactams. We believe that our strategy will provide direct access to γ-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy.
Charging properties and particles dynamics of Chang’E-5 lunar sample in an external electric field
Authors: Gu Junping , Qian Xiaoyu , Liu Yiwei , Wang Qinggong , Zhang Yiyang , Ruan Xuan , Deng Xiangjin , Lu Yaowen , Song Jian , Zhang Hui , Dong Yunning , Wei Mengmeng , Li Shuiqing , Wang Wei Hua , Zou Zhigang , Yang Mengfei , Yao Wei 
Published: May 2023

Abstract
Facing to the challenges of the lunar regolith resource in-situ utilization, applying an external electric field to manipulate lunar particle becomes a promising space particle control method, which is mainly dependent on the particle charging properties in the applied electric field. In the present work, the surficial lunar regolith sample returned from the Moon by the Chang’E-5 mission (CE5 LS) were used to study its charging properties and particles dynamics under the action of an applied external electric field for high-vacuum condition. Some interesting phenomena regarding the charging process and electrostatic projection were observed and discussed. The experimental data of particle charges, charge-to-mass ratio and the pre-collision parameters of CE5 LS were obtained. Furthermore, the influences of the projected CE5 LS collision on the target colliding surfaces were studied simultaneously. Our work would provide a solid support for the future study of the lunar regolith in-situ utilization and defense.
A new protocol of methamphetamine dependence treatment with taper-up-off treatment of opium tincture, a new hope to cure the methamphetamine addiction
Authors: Dezhakam Hossein , Dezhakam Amin , Dezhakam Shani , Dezhakam Ani , Haghighatfard Arvin 
Published: May 2023

Abstract
Methamphetamine is a neurotoxic drug and highly addictive stimulant, which causes a significant psychological dependence in use disorder and potential brain damage even in the first use disorder. Despite decades of research, no approved pharmacotherapy is available for methamphetamine (METH) use disorder, and behavioral therapies are faced with a great lack of long-term recovery and a high rate of relapse. Opium tincture is air-dried Papaver somniferum latex, formulated for oral administration. The present study aimed to evaluate the effectiveness of the new protocol for taper up-off method of opium tincture used for treatment of methamphetamine addiction in Iran, for more than 10 years. In the present study, the effectiveness of the Opium tincture taper-up-off treatment method for methamphetamine dependence called "Dezhakam step time (DST) for methamphetamine" was assessed. We used data collected via the "Congress 60" a non-governmental organization in Iran, dedicated to addiction treatment with the DST method, from Jan 2018 until December 2020. We evaluated the treatment safety, success, and relapse rate in methamphetamine dependents treated in the "Congress 60" organization with the DST for methamphetamine method. All subjects were tested using Urine drug monitoring for both opioid and methamphetamine use after the treatment period and during the next two years as a follow-up. Findings revealed 89 percent of successful treatments for methamphetamine dependence and only 11 percent of substance abuse relapses in two years follow up. Also, less than one percent of the subjects that finished the treatment program abused opioids in two years follow up. Findings suggest the safety and effectiveness of the Opium tincture taper-up-off method in the treatment of methamphetamine dependence. The findings of the study may help to a better understanding of a safe potential novel method for methamphetamine dependence treatment and its effects on psychological dependence on psychostimulants.
Comparative Clinical Trial to Evaluate the Efficacy and Toxicity of Bepostastine Besilate 1,5% Preservative-free vs Olopatadine Hydrochloride 0,2 Bak-preserved in Patients With Allergic Conjuctivitis
Authors: Marini Maria Cecilia , Berra Martín L. , Girado Fernanda , Albera Paula , Papa Melina S. del , Passerini María Silvia , Aguilar Alejandro 
Published: May 2023

Abstract
Purpose: To study the efficacy and toxic effects on ocular surface of bepotastine besilate 1,5% preservative-free (BB-PF) in comparison to olopatadine 0,2% BAK-preserved (OL-BAK) eyedrops in patients with allergic conjunctivitis.
Methods: 97 patients with allergic conjunctivitis diagnosis participate in a prospective, multicenter, randomized, double-blind, controlled, parallel-groups clinical trial. Patients received BB-PF (n=48) or OL-BAK (n= 49) both applied once a day at morning. Patients were followed for 60 days of treatment. Primary efficacy outcome was ocular itching. Secondary outcomes included ocular symptoms and signs, non-ocular symptoms associated with rhinoconjunctivitis. Conjunctival impression cytology (CIC) was performed to evaluate histopathology changes related with preservatives toxic effects.
Results: BB-PF treatment was associated with 1.30 more probability to diminished ocular itching in comparison to OL-BAK OR: 1.3 (CI 95% 0.96-1.7) p= 0.086. There were not any statistically significance between treatments in others ocular symptoms or signs, except for tearing that was superior in BB-PF (OR: 1.37 CI 95% 1.26-1.47, p<0.0001). BB-PF was superior in the resolution of rhinorrhea (p=0.040) and nasal itching (p= 0.037). BB-PF treatment was associated with 2.0 more probability to present a lower grade of Nelson scale in comparison to OL-BAK through 60 days of treatment OR: 2.00 (CI 95% 1.19-3.34), p= 0.010).
Conclusions: Both medications under study presented a similar profile in the resolution of ocular signs of symptoms associated with ocular conjunctivitis. BB-PF was superior in the resolution of non-ocular symptoms and was safer for the ocular surface in comparison to OL-BAK.
Causes of Excess Capacity in Indian Manufacturing Sector
Authors: Pal Samidh 
Published: May 2023

Abstract
This study delves into the origins of excess capacity by examining the reactions of capital, labor, and capital intensity. To achieve this, we have employed a novel three-layered production function model, estimating the elasticity of substitution between capital and labor as a nested layer, alongside capital intensity, for all industry groups. We have then selectively analyzed a few industry groups for comparative purposes, taking into account the current government policies and manufacturing plant realities. Ultimately, we recommend that policymakers address the issue of excess capacity by stimulating the expansion of manufacturing plants with cutting-edge machinery. Our findings and recommendations are intended to appeal to academics and policymakers alike.
JEL Code: L6, L5.
Determinants and Spatial Patterns of Anaemia and Haemoglobin Concentration among Pregnant Women in Nigeria Using Structured Additive Regression Models
Authors: Adeniyi Isaac Adeola , Ezenweke Chinenye Pauline , Yahya Waheed Babatunde , Onoja Rhoda Enemona 
Published: May 2023

Abstract
Anaemia which is a condition that describes low haemoglobin (Hb) levels has been recognized as a major public health problem among pregnant women in many sub-Saharan African countries including Nigeria. The causes of maternal anaemia which are interconnected and complex vary between countries and can vary within a country. This study aimed to investigate the spatial pattern and identify demographic and socio-economic determinants associated with anaemia among Nigerian pregnant women aged 15-49 years using data from the 2018 Nigeria Demographic and Health Survey (NDHS). This study utilized chi-square tests of independence and semiparametric structured additive models to describe the relationship between the presumed factors and anaemia status or Hb level while also taking spatial effects at state level into account. The Gaussian and Binomial distributions were used for Hb level and anaemia status respectively. The overall observed prevalence of anaemia in pregnant women and average Hb level in Nigeria were 64% and 10.4 (SD = 1.6) g/dL respectively while the prevalence of mild, moderate and severe anaemia were 27.2%, 34.6% and 2.2% respectively. Higher education, older age, and currently breastfeeding were associated with higher Hb level. Low education, being unemployed and recently having a sexually transmitted infection were identified as risk factors for maternal anaemia. Body mass index (BMI) and household size had a nonlinear effect on Hb level while BMI and age were nonlinearly related to odds of anaemia. Bivariate analysis indicated that living in rural area, low wealth class, using unsafe water and non-usage of internet were significantly associated with increased risk of anaemia. Maternal anaemia prevalence was highest in the South Eastern part of Nigeria with Imo state producing the highest prevalence of maternal anaemia while Cross River state yielded the lowest prevalence of maternal anaemia. The spatial effects associated with states were significant but unstructured indicating that states in close proximity do not necessarily share similar spatial effects. Hence, unobserved characteristics shared by states in close proximity do not influence maternal anaemia and Hb level. The findings from this study can undoubtedly help in the planning and designing of anaemia interventions that match local conditions taking into consideration the aetiology of anaemia in Nigeria.
Preparation of Nano-Metal-Oxide Incorporated Biochar for Remediation of Water Pollution
Authors: Arar Ozgur 
Published: May 2023

Background:
Because of its numerous advantages, biochar has been widely used to remove
contaminants from aqueous media for several years. However, unmodified biochar often exhibits
low sorption capacity. Therefore, various nano-sized metal oxides have been developed to
modify biochar and improve its ability to remove impurities

Objective:
This review aims to provide information on preparing and applying biochar loaded with
nano-sized metal oxides to treat pollutants in water samples.

Results:
Raw biochar has limited applicability/capacity for certain pollutants, such as inorganic anions.
However, modification with metal oxides improved removal performance, sorption capacity,
and selectivity.

Conclusion:
Biochar loaded with metal oxides is believed to be an environmentally friendly alternative
for treating polluted water. Selective sorbents with high capacity and fast kinetics towards
undesirable solutes can be produced using suitable metal oxides. The sorbent can remove pollutants
from solutions with a high removal rate
Cost-Effectiveness Analyses of Digital Health Technology for Improving the Uptake of Vaccination Programs: Systematic Review
Authors: Wang Yingcheng , Fekadu Ginenus , You Joyce Hoi-sze 
Published: May 2023

Background
Vaccination is the most effective strategy to prevent infectious diseases, yet vaccination coverage has not reached the target level. To promote vaccination uptake, digital health interventions (DHIs) have been used in various vaccination programs.

Objective
This study aimed to perform a systematic review of the cost-effectiveness analyses of DHIs for the improvement of the uptake of vaccination programs.

Methods
A literature review was conducted in MEDLINE (Ovid), Embase (Ovid), APA PsycINFO (Ovid), Web of Science, Scopus, CINAHL Ultimate (EBSCOhost), Center for Review and Dissemination, and Institute for IEEE Xplore up to October 2022. Health economic evaluations that met the following inclusion criteria were included: (1) adult or pediatric vaccination programs; (2) interventions delivered through digital technology; (3) full-scale health economic analyses including cost-effectiveness, cost-utility, cost-benefit, or cost-consequence analyses; and (4) evaluations conducted by model-based or trial-based analyses. The quality of each included study was evaluated using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS).

Results
The systematic review included 7 studies. Four of the cost-effectiveness studies were conducted by model-based analyses, and 3 were trial-based analyses. One study reported the additional cost per quality-adjusted life years (QALYs) gained, whereas 6 studies reported the additional cost per individual vaccinated (or return case). The vaccines targeted the human papillomavirus (HPV) vaccine, influenza vaccination, measles-mumps-rubella (MMR) vaccine, and children immunization at different ages. The DHIs were delivered by television campaign, web-based decision aid, SMS text message, telephone, and computer-generated recall letters. The studies were classified as very good (n=5) and good (n=2) qualities. One study concluded that the DHI was cost-saving, and 6 studies concluded that the DHI was cost-effective.

Conclusions
This study is the first systematic review on cost-effectiveness analyses of DHIs to improve vaccination uptake. All included studies have good to very good quality on study assessment and reported the DHIs to be cost-saving or cost-effective in the improvement of vaccination uptake.