bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term results and complications of the operative treatment of the distal radius fracture AO2R3 C type, planned by using 3D-printed models. Prospective randomized control study
Authors: Grinčuk Aleksandr , Petryla Giedrius , Masionis Povilas , Sveikata Tomas , Uvarovas Valentinas , Makulavičius Aleksas 
Published: August 2023

Purpose 3D-printed models rapidly evolving in orthopaedic. Studies show that 3D-printed models used for preoperative planning improve a better understanding of fracture morphology and reduce operative time, blood loss and frequency of fluoroscopy, but there are no studies that investigated possible advantages in the outcomes and complications for the treatment of distal radius fracture (DRF). Our study aims to evaluate short-term functional results and complications between two groups treated DRF using 3D-printed models for preoperative planning and without. We hypothesize that the addition of 3D-printed models would improve functional outcomes and reduce complication rates. Methods 66 randomized cases of DRF AO/OTA C type were enrolled and divided into “Control group” ( n = 33) and “3D-printed model group” ( n = 33). Personalized 3D-printed models were created. The primary outcomes were: Patient-Rated Wrist Evaluation questionnaire, Quick Disabilities of the Arm, Shoulder and Hand Score questionnaire, and complications. The secondary outcomes were: measurement of the range of motions, grip strength, radiological evaluation, and the visual analogue scale. Assessments were measured at 6 weeks, 3 months, and 6 months intervals. Results We found that the integration of the 3D-printed model in preoperative planning decreased complication incidence significantly – from 30.3% in the “Control group” to 6.1% in the “3D-printed model group”, p = .022. But we did not find a difference in functional and radiological outcomes. Conclusion The 3D-printed models for preoperative planning surgically treating DRF AO/OTA C type can help minimize the complication rate, however, they can’t improve functional outcomes in the short-term results. Level of evidence Level I randomized controlled study.
What are the evidence bases for developing models of rehabilitation for older people with mental illness in Australia?
Authors: McKay Roderick , Jackson Kate 
Published: August 2023

Objective This paper updates clinicians and service leaders on evidence bases relevant to rehabilitation for older Australians with mental illness. Methods Narrative review of literature and relevant public domain data supported by reflections on NSW service development. Results There is a paucity of high-quality evidence regarding mental health rehabilitation in older people. Available evidence supports integrating lessons from physical healthcare with adaptations of ‘adult’ mental health rehabilitation. Adaptation is required to respond to the specific needs, strengths and service use of older people with mental illness. Challenges for older people include ageism, increased physical and cognitive comorbidities, lower access to mental health services and earlier residential aged care entry. Strengths of older people include an ongoing desire for recovery, ongoing developmental change and often closer connections with carers and GPs. Evidence is consistent with evaluation of relevant NSW service models and initiatives including the Pathways to Community Living Initiative. Integration of recovery-oriented practice and wellness models may provide a framework for future innovative inpatient and community-based models. Conclusions There is sufficient evidence to guide development of models of rehabilitation with older people, but innovation and evaluation are essential if older people are to have equal opportunities in their recovery journeys.
Commentary: Using Language to Improve Health
Authors: Berger Jonah , Packard Grant 
Published: August 2023

Communication plays an integral role in service interactions and language shapes how service agents talk to customers, salespeople talk to prospects, and chatbots talk to consumers. But as Danaher, Berry, Howard, Moore, and Attai (2023) note, given healthcare’s impact on quality of life, it’s a particularly important domain to study effective communication. Their useful review and framework should help medical professionals improve patient interactions and encourage future research. That said, one paper can only cover so much ground, and there are several additional areas that deserve further attention. Building on their framework, we offer some additional areas for future work, including how to use language to better understand patients, how communication mediums (e.g., writing vs. speaking or online portals vs. email) shape what gets communicated, and how effective communication depends on the interaction’s goals (e.g., persuasion vs. medical adherence).
Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018
Authors: Hu Wanqin , Ye Ziwei , Li Tao , Shi Zeya 
Published: August 2023

Introduction: To explore the relationship between the composite dietary antioxidant index (CDAI) and gout to provide support for preventing gout through dietary intervention. Methods: Eligible participants from the 2007 to 2018 National Health and Nutrition Examination Survey aged 20 years and older were included in this cross-sectional study. The weighted chi-square test was used to compare the categorical variables difference between CDAI quartiles groups. The weighted univariate and binary logistic regression analysis were used to test the association between variables and gout. The weighted multivariable logistic regression was used to test the association of CDAI and gout in 4 different models. Subgroup analysis on the associations of CDAI with gout was conducted with stratified factors. Results: The final participants were 26,117, 13,103 (50.17%) were female, 8718 (33.38%) were 40–59 years, 11,200 (42.88%) were white and 1232 (4.72%) had gout. After adjusting for all covariates, the CDAI was associated with gout (odds ratio (OR), .97; 95% CI: .95–1.00). Participants in the highest CDAI quantile group were at low risk of gout (odds ratio (OR), .65; 95% CI: .50–.84) versus those in the lowest quantile group. Subgroup analysis and interaction test showed no significant dependence on diabetes mellitus (DM), marital status, alcohol status, hypertension, poverty income ratio (PIR), education level, body mass index (BMI), smoke status, age, sex, race, and chronic kidney disease (CKD) on this association (all p for interaction >.05). Conclusions: Composite dietary antioxidant index was inversely associated with gout in US adults, and dietary antioxidant intervention might be a promising method in the therapy of gout and greater emphasis should be placed on zinc, selenium, carotenoids, vitamins A, C, and E.
Use of antegrade wire guidance for retrograde transjugular/transfemoral venous access in the treatment of dysfunctional hemodialysis access: A retrospective analysis
Authors: Lee Yoonhee , Park Suyoung , Kim Jeong Ho , Hwang Jung Han , Shim Young Sup , Kim Dong Kyu 
Published: August 2023

Background: Transvenous access for endovascular treatment of dysfunctional hemodialysis (HD) access can be technically difficult in the retrograde selection of the HD access. This study aims to evaluate the efficacy of primary antegrade wire guidance in assisting transvenous access. Methods: A total of 41 transvenous access procedures (17 with and 24 without antegrade wire guidance), performed between March 2019 and February 2023, were included. Electronic medical records and procedural images were retrospectively reviewed. Results: Of the 41 procedures, 17 performed primary antegrade wire guidance (group A) and 24 did not (group B). The technical success rate was 100% in group A and 95.8% (23/24) in group B. The mean retrograde selection time was 16.7 min in group A, whereas it was 30.9 min in group B ( p = 0.014). Additional intraprocedural fistulography was not performed in group A, while it was performed at an average of 1.5 times (range: 0–4) in group B ( p = 0.001). One patient in group B experienced venous dissection as a minor complication; however, no major complications were observed in either of the groups. Conclusions: Using primary antegrade wire guidance in endovascular treatment of dysfunctional HD access via alternative transvenous access is safe and time-saving.
Cross-linguistic influence in the comprehension of reflexive possessive pronouns in L3 and L4 Swedish
Authors: Długosz Kamil 
Published: August 2023

Aims and Objectives: The study investigates the extent to which offline and online comprehension of reflexive possessive pronouns in L3 and L4 is modulated by previously acquired native and non-native grammars. Design/Methodology/Approach: Thirty-one intermediate to advanced L1 Polish learners of Swedish, who have also acquired German and English (L4 Swedish learners) or only English (L3 Swedish learners), completed a self-paced reading task and a grammaticality judgement task. The tasks targeted learners’ sensitivity to possessor and possessee agreement violations. Data and Analysis: Reading times and judgement accuracy were collected and analysed using generalised linear models. Findings/Conclusions: In online comprehension, L3/L4 Swedish learners showed sensitivity to possessor and possessee agreement, which was affected neither by their proficiency, nor by their prior native and non-native grammars. In offline comprehension, however, they had difficulty deploying possessor and possessee agreement. Performance on possessee but not possessor agreement increased with advancing proficiency, indicating the persistent influence of L1 Polish grammar. Furthermore, L4 Swedish learners achieved an overall higher judgement accuracy than L3 Swedish learners. At the same time, L4 Swedish learners read the relevant regions longer than L3 Swedish learners, suggesting a speed–accuracy trade-off for L4 Swedish learners. Originality: The study investigates cross-linguistic influence in the comprehension of reflexive possessive pronouns in multilingual learners, which has not been explored before. It is also the first to provide evidence for a multilingual advantage in the accuracy of reflexive possessive agreement, albeit at the cost of reading speed. Significance/Implications: The study demonstrates that native and non-native grammars differently affect the offline comprehension of reflexive possessive pronouns in L3 and L4. The native language seems to have a more direct effect that consists in the employment of agreement mechanisms, while the non-native language has a more indirect effect, as it can increase learners’ sensitivity to morphosyntactic violations.
Clinical validation of a wearable respiratory rate device: A brief report
Authors: Eisenkraft Arik , Goldstein Nir , Ben Ishay Arik , Fons Meir , Tabi Michael , Sherman Anna Danielle , Merin Roei , Nachman Dean 
Published: August 2023

Background Respiratory rate (RR) is used for the diagnosis and management of medical conditions and can predict clinical changes. Heavy workload, understaffing, and errors related to poor recording make it underutilized. Wearable devices may facilitate its use. Methods RR measurements using a wearable photoplethysmography-based monitor were compared with medical grade devices in complementary clinical scenarios: Study one included a comparison to a capnograph in 35 healthy volunteers; Study two included a comparison to a ventilator monitor in 18 ventilated patients; and Study three included a comparison to capnograph in 92 COVID-19 patients with active pulmonary disease. Pearson’s correlations and Bland-Altman analysis were used to assess the accuracy and agreement between the measurement techniques, including stratification for Body Mass Index (BMI) and skin tone. Statistical significance was set at p ≤ 0.05. Results High correlation was found in all studies (r = 0.991, 0.884, and 0.888, respectively, p < 0.001 for all). 95% LOA of ±2.3, 1.7-(−1.6), and ±3.9 with a bias of < 0.1 breaths per minute was found in Bland-Altman analysis in studies 1,2, and 3, respectively. In all, high accordance was found in all sub-groups. Conclusions RR measurements using the wearable monitor were highly-correlated with medical-grade devices in various clinical settings. Trial registration ClinicalTrials.gov , https://clinicaltrials.gov/ct2/show/NCT03603860 .
The Effect of Mediterranean Diet on Body Composition, Inflammatory Factors, and Nutritional Status in Patients with Cachexia Induced by Colorectal Cancer: A Randomized Clinical Trial
Authors: Bagheri Amir , Asoudeh Farzaneh , Rezaei Saied , Babaei Mohammad , Esmaillzadeh Ahmad 
Published: August 2023

Background: Along with high calorie and high protein diet, a new comprehensive dietary approach is needed to control cachexia caused by cancer and its related outcomes. This study was done to evaluate the effect of a Mediterranean diet on body composition, nutritional status, and inflammatory markers among cancer cachexia patients. Methods: In this randomized clinical trial, 46 patients with colorectal cancer-induced cachexia were included. After randomization, 23 patients were allocated to the intervention group (Mediterranean diet) and 23 to the control group (nutritional counseling for weight gain and prevention of weight loss in cancer patients). The primary outcome including muscle health, nutritional status, and inflammatory markers along with secondary outcomes such as quality of life, and serum proteins were evaluated at the start and the eighth week of the study. Statistical analysis was performed according to the intention-to-treat concept. To compare changes in dependent variables between the 2 groups, analysis of covariance (ANCOVA) was performed. Results: After adjustment for the baseline values, age, sex, and supplements use, in the Mediterranean diet group mean of weight ( P < .001), lean body mass ( P = .001), fat mass ( P = .002), and muscle strength ( P < .001) were significantly increased compared to the control group. Regarding inflammatory markers, the mean serum level of tumor necrosis factor-alpha (TNF-α) ( P < .001), high sensitive-C-reactive protein (hs-CRP) ( P = .01) and Interleukin 6 (IL-6) ( P < .001) were significantly improved in the Mediterranean diet group. Moreover, in the Mediterranean diet group, the score for global health status ( P = .02) and physical performance score ( P < .001) were significantly increased. Conclusion: It appears that the implementation of the Mediterranean diet might be a strategy to improve nutritional status, quality of life, inflammatory markers, and body composition in patients with colorectal cancer cachexia. Trial registration: Iranian Registry of Clinical Trials ( www.irct.ir ); ID: IRCT20211027052884N1
Correlation analysis of structural and functional changes in the carotid artery in patients with H-type hypertension using ultrasound radiofrequency
Authors: Ma Hai-Yan , Chen Xue-Ying , Jin Hong , Deng Yao-Yao , Xiong Ya-Ming , Chang Xuan , Kong Xiang-Hui , Li Ming 
Published: August 2023

Objectives To perform a correlation analysis on the structural and functional changes of the carotid artery in patients with H-type hypertension. Methods Outpatients and inpatients with hypertension in our hospital between 2017 and 2018 were selected and divided into the H-type hypertension group (primary hypertension + plasma homocysteine ≥ 10 umol/l) ( n = 30) and the simple hypertension group (primary hypertension + plasma Hcy < 10 umol/l) ( n = 30) based on the plasma homocysteine (Hcy), and 30 healthy people were included in the control group. Thickness and stiffness parameters of the intima of the carotid artery (compliance coefficient [CC], stiffness index [β], and pulse wave velocity [PWV]) were measured for all study participants using ultrasound radiofrequency signal-based quality intima-media thickness (QIMT) and quantitative arterial stiffness (QAS) for contrast analysis. Results Indexes such as QIMT, β, and PWV of the carotid artery were significantly higher, and the CC was significantly lower in the H-type hypertension group and simple hypertension group than the control group ( p < .05), and the difference was statistically significant; these indexes were significantly higher in the H-type hypertension group than in the simple hypertension group, and the CC was significantly lower than in the control group ( p < .05), and the difference was statistically significant. Conclusions Hypertension can accelerate structural and functional changes of the carotid artery intima, with these changes being more significant in H-type hypertension. The ultrasound radiofrequency technique can be used to quantitatively evaluate the structure and function of the carotid artery in patients with H-type hypertension.
Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities of Crataegus monogyna Jacq Aqueous Extract
Authors: Radi Fatima Z. , Bencheikh Noureddine , Bouhrim Mohamed , Saleh Asmaa , Al kamaly Omkulthom , Parvez Mohammad K. , Elbouzidi Amine , Bnouham Mohamed , Zair Touriya 
Published: August 2023

Objective This study aims to evaluate the phytochemical composition, antioxidant, and antihyperglycemic (in vivo, in vitro, and in silico) activities and acute toxicity of Crataegus monogyna Jacq ( C monogyna) aqueous extracts. Methods The study analyzed the aqueous extract of C monogyna through various methods such as phytochemical screening, and the high-performance liquid chromatography-ultraviolet (HPLC-UV)-visible analysis. The extract was also tested for antioxidant potential, acute toxicity, antihyperglycemic effect, and inhibitory effect on the pancreatic α-amylase enzyme. Additionally, the study used the molecular docking approach to identify the most potent ligands in the extract. Results The phytochemical screening of the aqueous extract of C monogyna showed the presence of flavonoids, tannins, coumarins, sterol, and triterpene. The extract was rich in total polyphenols (1.65 ± 0.04 mg gallic acid equivalent per gram of extract [GAE/g] DM), total flavonoids (0.33 ± 0.03 EQ/g DM), and condensed tannins (0.28 ± 0.01 EC/mg DM). HPLC-UV-visible analysis identified 9 phenolic compounds, with high levels of gallic acid and caffeic acid. The C monogyna extract has a high antioxidant activity with an IC50 of 9.23 ± 0.01 mg/mL by DPPH and 8.32 ± 0.02 mg/mL by FRAP. The aqueous extract of C monogyna was not toxic to albino mice. The glucose tolerance test showed a significant antihyperglycemic effect, with an IC50 of 0.070 ± 0.008 mg/mL for the inhibition of pancreatic α-amylase activity by the aqueous extract of C monogyna. The in vivo inhibitory effect of the extract on the pancreatic α-amylase enzyme was confirmed. Two flavonoids, catechin, and rutin, were identified as potent inhibitors of the activity of α-amylase in the in silico part of the study, compared to the native ligand, Acarbose. Conclusion The study found that C monogyna has significant antioxidant and antihyperglycemic properties. The presence of catechin and rutin may contribute to these effects. The results suggest that C monogyna could be used as a dietary supplement to prevent and treat diabetes.
Clinical relevance of potential self-medication drug interactions in antineoplastic and immune-modulating therapy among online pharmacy customers
Authors: Schindler Florian , Schinkoethe Timo , Mahner Sven , Kolben Thomas , Wuerstlein Rachel , Culmsee Carsten , Harbeck Nadia , Eggersmann Tanja K. 
Published: August 2023

Background: Modern oral antineoplastic and immune-modulating drugs offer an array of therapeutic advantages, and yet pose challenges in daily use for patients, physicians and pharmacists. In contrast to intravenous administration, these drugs are not subject to direct medical control. Recently, we have seen a huge rise in sales of non-prescription over-the-counter (OTC) medicines via the internet without any advice from a healthcare professional. Objectives: The aim of this study was to investigate whether the risk of known potential drug-drug interactions between modern oral antineoplastic and immune-modulating drugs and OTC drugs differs between sales in traditional community pharmacies versus online pharmacies. Design: Real-life sales data from community and online pharmacies were used as basis for the analysis. Methods: We determined the most frequently purchased antineoplastic and immune-modulating drug-substances in 14 local community pharmacies within the Munich area, Germany and identified the OTC substance groups that could potentially cause interactions with oncological therapies. Using sales data from 11 local community pharmacies and three online pharmacies, we investigated whether OTC purchases differed between the two sales channels. Results: We identified 10 relevant OTC substance classes and detected significant variations in patients’ preferred sales channels between the drug classes. Certain OTC drugs, which seem to be bought more often over the internet, pose risks during antineoplastic and immune-modulating therapy. Conclusion: Patients should therefore be proactively made aware of the corresponding risks in order not to jeopardize the activity of the antineoplastic and immune-modulating drugs and thus the success of their therapy.
A new early warning method for mild cognitive impairment due to Alzheimer's disease based on dynamic evaluation of the “spatial executive process”
Authors: Li Kai , Ma Xiaowen , Chen Tong , Xin Junyi , Wang Chen , Wu Bo , Ogihara Atsushi , Zhou Siyu , Liu Jiakang , Huang Shouqiang , Wang Yujia , Li Shuwu , Chen Zeyuan , Xu Runlong 
Published: August 2023

Objective Mild cognitive impairment (MCI) due to Alzheimer's disease (AD), as an early stage of AD, is an important point for early warning of AD. Neuropathological studies have shown that AD pathology in pre-dementia patients involves the hippocampus and caudate nucleus, which are responsible for controlling cognitive mechanisms such as the spatial executive process (SEP). The aim of this study is to design a new method for early warning of MCI due to AD by dynamically evaluating SEP. Methods We designed fingertip interaction handwriting digital evaluation paradigms and analyzed the dynamic trajectory of fingertip interaction and image data during “clock drawing” and “repetitive writing” tasks. Extracted fingertip interaction digital biomarkers were used to assess participants’ SEP disorders, ultimately enabling intelligent diagnosis of MCI due to AD. A cross-sectional study demonstrated the predictive performance of this new method. Results We enrolled 30 normal cognitive (NC) elderly and 30 MCI due to AD patients, and clinical research results showed that there may be neurobehavioral differences between the two groups in digital biomarkers captured during SEP. The early warning performance for MCI due to AD of this new method (areas under the curve (AUC) = 0.880) is better than that of the Minimum Mental State Examination (MMSE) neuropsychological scale (AUC = 0.856) assessed by physicians. Conclusion Patients with MCI due to AD may have SEP disorders, and this new method based on dynamic evaluation of SEP will provide a novel human–computer interaction and intelligent early warning method for home and community screening of MCI due to AD.