bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fear of missing out and depressive symptoms during the COVID‐19 pandemic
Authors: LeRoy Angie S. , Lai Vincent D. , Tsay‐Jones Arya , Fagundes Christopher P. 
Published: June 2023

AbstractDuring the early stages of the COVID‐19 pandemic, governments issued public health safety measures (e.g., “stay‐at‐home” ordinances), leaving many people “missing out” on integral social aspects of their own lives. The fear of missing out, popularly shortened as, “FoMO,” is a felt sense of unease one experiences when they perceive they may be missing out on rewarding and/or enjoyable experiences. Among 76 participants (ages M = 69.36, SD = 5.34), who were at risk for hospitalization or death if infected with COVID‐19, we found that FoMO was associated with depressive symptoms at Time 1, even when controlling for perceived stress, loneliness, and fear of COVID‐19. However, FoMO did not predict future depressive symptoms, about 1 week later, when controlling for Time 1 depressive symptoms. These findings provide further evidence that FoMO is associated with depressive symptoms in a short period of time even when accounting for other powerful social factors such as loneliness. Future research should explore the potential causal relationships between FoMO and depression, especially those that may establish temporal precedence.
NeuroSPE: A neuro‐net spatial relation extractor for natural language text fusing gazetteers and pretrained models
Authors: Qiu Qinjun , Xie Zhong , Ma Kai , Tao Liufeng , Zheng Shiyu 
Published: June 2023

AbstractSpatial relations are frequently described and used in natural language texts, and relations play a core role in a range of applications—from supporting geographic information retrieval in natural language texts to locating people and objects in natural disaster response situations. In this article, we present a neuro‐net spatial extraction model (NeuroSPE) designed to address various language irregularities (i.e., a variety of sentence structures) that occur in natural language texts. We also propose a two‐stage workflow to generate a training dataset based on a collection of words and their associated frequencies. The first stage of the proposed workflow focuses on processing the words in the input data and their associated frequencies; then, the words are segmented into a set of groups and used to accelerate model training. The second stage automatically generates a variety of sentences that include two geographic entities and related spatial relation terms through deep learning iteration based on a unigram language model. We evaluate our method both qualitatively and quantitatively using a real dataset. The experimental results demonstrate that the proposed two‐stage workflow effectively extracts spatial relations from natural language texts and outperforms other current state‐of‐the‐art approaches.
Deep trade agreements and trade costs
Authors: Hou Yulin 
Published: June 2023

AbstractDeep trade agreements (DTAs) have boomed in recent years and extended their reach well beyond tariff liberalisation. This paper investigates the impact of deep trade agreements on trade costs from a global perspective. The results show that trade costs between partners that sign an agreement with the highest depth decrease by 10.3%. The results are shown to be robust to the consideration of interval data, different measures of the trade agreement depth, different datasets, and alternative estimation strategy. Furthermore, we provide supportive evidence of the spillover effect of DTAs. We find that non‐discriminatory provisions in DTAs significantly lower non‐tariff costs for non‐member countries, especially for agricultural goods.
One generalist or several specialists? Comparative analysis of the polyphagous butterfly Adelpha serpa celerio and its serpa‐group relatives
Authors: Rush Cassidi E. , Freitas André V. L. , Magaldi Luiza , Willmott Keith R. , Hill Ryan I. 
Published: June 2023

AbstractPatterns of larval food plant use and immature stage morphology help clarify Neotropical butterfly species diversity, and, in many cases, lineages identified with molecular data are corroborated by morphology and ecology of immature stages. Here, we investigate cryptic species in Adelpha butterflies (Nymphalidae), a group known for challenging adult wing similarity coupled with mimicry, and for its remarkably wide larval food plant breadth. We focus on the Adelpha serpa‐group and in particular Adelpha serpa celerio, whose immatures have been documented feeding on 11 plant families. Our analyses of A. serpa, and among serpa‐group species across the Neotropics, revealed evidence of cryptic species, but the pattern within A. serpa celerio showed relatively weak mtDNA and morphological differences, and no differentiation in food plant use. We conclude that A. serpa should be revised and recognize A. serpa to include the nominate subspecies and recognize A. celerio (revised status) as a geographically widespread species and a larval food plant generalist that contains A. c. celerio (revised status), A. c. duiliae (revised status) and A. c. diadochus (revised status). Four additional species within the serpa‐group show strong evidence of harbouring allopatric cryptic species, and further research should be done to clarify their species limits.
Synergistic Effects and Kinetics in Co-Pyrolysis of Waste Tire With Five Agricultural Residues Using Thermogravimetric Analysis
Authors: Wang Zhiwei , Guo Shuaihua , Chen Gaofeng , Zhang Mengju , Sun Tanglei , Chen Yan , Wu Mengge , Xin Xiaofei , Yang Shuhua , Lei Tingzhou , Burra Kiran G. , Gupta Ashwani K. 
Published: June 2023

Abstract
Continued social and mobility development has caused a sharp increase in the number of waste tires, increased environmental pollution, and waste of limited resources. Agricultural residues as a bioresource, which has drawn increased attention in recent years. The thermochemical conversion of waste tires and agricultural residues and their mixtures offers important prospects for scientific development, which can provide energy security and a much reduced environmental footprint. In this paper, pyrolysis of waste tires and its co-pyrolysis with maize stalk, wheat straw, cotton stalk, rape straw, or peanut shell agricultural residues, in mass ratios of 1:1 were investigated at different heating rate using thermogravimetric analysis. The kinetic parameters were calculated using Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) kinetic models at heating rates of 20, 30, and 50 °C/min. The synergistic effect between waste tires and agricultural residues was explored by calculating the deviation between the experimental and calculated values. The results showed the presence of a synergistic effect between the co-pyrolysis of waste tires and the residual agricultural residues. In the kinetic analysis, activation energies of waste tires, agricultural residues, and their mixtures were calculated using the two models. The reaction followed a multistage reaction mechanism. The differential thermogravimetry behavior of the mixture was similar to the weighted aggregate results of the waste tire and agricultural waste samples, pyrolyzed separately. These results provide some insights into the combined treatment of waste tires and agricultural waste residues.
Understanding the Impact of an Online Level 1 Coach Education Award on Dodgeball Coaches’ Learning and Practice
Authors: Leeder Thomas M. , Beaumont Lee C. , Maloney Ciaran M.C. 
Published: June 2023

Improved internet access and technological advancements have significantly influenced coaches’ learning opportunities, with numerous online coach education courses now available. Despite this, we know little about coaches’ experiences of such provision and how it shapes coach learning. Consequently, the aim of this research is to understand the impact of an online Level 1 coach education award on dodgeball coaches’ learning and practice. Data were collected via an online qualitative survey involving 57 dodgeball coaches who had completed the award, alongside follow-up virtual semistructured interviews with eight coaches. Following a reflexive thematic analysis process drawing upon the theoretical framework of Jennifer Moon, three themes were generated: (a) a surface or deep approach? Understanding dodgeball coaches’ experiences of the Level 1 award, (b) coaches’ preferences and learning styles: a barrier for online coach education, and (c) enhancing the impact of online coach education: assessment and postaward support. Findings indicate that the award’s impact on learning and practice varied depending upon coaches’ cognitive structures, which influenced their perceptions toward the value of online provision. Although coaches’ experiences were generally positive, authentic assessment(s) and mentoring opportunities were proposed to further enhance the award’s impact.
Diagnostic accuracy of endometrial sampling tests for detecting endometrial cancer: a systematic review and meta-analysis
Authors: Sakna Noha Abdelsattar , Elgendi Marwa , Salama Mohamed Hamed , Zeinhom Ahmed , Labib Somia , Nabhan Ashraf Fawzy 
Published: June 2023

ObjectivesTo determine the diagnostic accuracy of different endometrial sampling tests for detecting endometrial carcinoma.DesignSystematic review and meta-analysis of studies of diagnostic accuracy.Data sourcesCochrane Library, MEDLINE/PubMed, CINAHL, Web of Science and Scopus, from the date of inception of the databases to 18 January 2023. Additionally, the reference lists of included studies and other systematic reviews were thoroughly searched.Eligibility criteriaWe included published cross‐sectional studies that evaluated any endometrial sampling test (index tests) in women (participants) with clinical suspicion of endometrial carcinoma (target condition) in comparison with histopathology of hysterectomy specimens (reference standard). We excluded case–control and case series studies. No restrictions on language or date of publication were applied.Data extraction and synthesisTwo independent reviewers extracted study data and assessed study quality using the revised quality assessment tool for diagnostic accuracy studies (QUADAS-2). We used bivariate diagnostic random-effects meta-analysis and presented the results in a summary receiver operating characteristic curve. We assessed the certainty of evidence as recommended by the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach.ResultsTwelve studies (1607 participants), published between 1986 and 2022, contributed data to the meta-analysis results. Seven studies were judged to be at a low risk of bias in all domains and all studies had low applicability concerns. The most studied index tests were Pipelle and conventional dilation and curettage (D&C). The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio (95% CIs) for Pipelle were 0.774 (0.565 to 0.900), 0.985 (0.927 to 0.997), 97.000 (14.000 to 349.000) and 0.241 (0.101 to 0.442) and for conventional D&C were 0.880 (0.281 to 0.993), 0.984 (0.956 to 0.995), 59.300 (14.200 to 153.000) and 0.194 (0.007 to 0.732), respectively.ConclusionHigh certainty evidence indicates that endometrial sampling using Pipelle or conventional D&C is accurate in diagnosing endometrial cancer. Studies assessing other endometrial sampling tests were sparse.Trial registration numberhttps://osf.io/h8e9z.
Causes of death in children with congenital anomalies up to age 10 in eight European countries
Authors: Rissmann Anke , Tan Joachim , Glinianaia Svetlana V , Rankin Judith , Pierini Anna , Santoro Michele , Coi Alessio , Garne Ester , Loane Maria , Given Joanne , Reid Abigail , Aizpurua Amaia , Akhmedzhanova Diana , Ballardini Elisa , Barisic Ingeborg , Cavero-Carbonell Clara , de Walle Hermien E K , Gatt Miriam , Gissler Mika , Heino Anna , Jordan Sue , Urhoj Stine Kjaer , Klungsøyr Kari , Lutke Renee , Mokoroa Olatz , Neville Amanda Julie , Thayer Daniel S , Wellesley Diana G , Yevtushok Lyubov , Zurriaga Oscar , Morris Joan 
Published: June 2023

BackgroundCongenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate the accuracy of using death certificates to estimate the burden of CAs on mortality for children under 10 years old.MethodsChildren born alive with a major CA between 1 January 1995 and 31 December 2014, from 13 population-based European CA registries were linked to mortality records up to their 10th birthday or 31 December 2015, whichever was earlier.ResultsIn total 4199 neonatal, 2100 postneonatal and 1087 deaths in children aged 1–9 years were reported. The underlying cause of death was a CA in 71% (95% CI 64% to 78%) of neonatal and 68% (95% CI 61% to 74%) of postneonatal infant deaths. For neonatal deaths the proportions varied by registry from 45% to 89% and by anomaly from 53% for Down syndrome to 94% for tetralogy of Fallot. In children aged 1–9, 49% (95% CI 42% to 57%) were attributed to a CA. Comparing mortality in children with anomalies to population mortality predicts that over 90% of all deaths at all ages are attributable to the anomalies. The specific CA was often not reported on the death certificate, even for lethal anomalies such as trisomy 13 (only 80% included the code for trisomy 13).ConclusionsData on the underlying cause of death from death certificates alone are not sufficient to evaluate the burden of CAs on infant and childhood mortality across countries and over time. Linked data from CA registries and death certificates are necessary for obtaining accurate estimates.
Update on advanced interventional neuromodulatory approaches to lower blood pressure
Authors: Kiuchi Marcio Galindo , Carnagarin Revathy , Schultz Carl , Shetty Sharad , Ward Natalie C , Santos Carlos Eduardo , Schlaich Markus P 
Published: June 2023

Herein, we review interventional peripheral neuromodulatory approaches to reduce blood pressure (BP), specifically focusing on catheter-based renal denervation (RDN), as well as the latest data from recent clinical trials underpinning its clinical use. Given the apparent failure of established lifestyle measures and pharmacologic BP-lowering approaches to improve hypertension (HTN) control rates, the past decade has seen remarkable scientific efforts to explore the utility of interventional strategies for BP management. Experimental studies and human clinical trials have demonstrated the crucial role of the sympathetic nervous system in the development and mainenance of HTN - consequently, most recent interventional technologies aimed primarily at modulating neural pathways. Advanced approaches that were rigorously tested in human studies include RDN, endovascular baroreflex amplification, baroreflex activation therapy and cardiac neuromodulation stimulation.Amongst these, RDN is by far the most established technology. With recent robust evidence from clinical trials and real-world data showing the safety and efficacy of both ultrasound and radiofrequency-based approaches, a recent clinical consensus statement of the European Society of Cardiology Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions concludes that RDN represents an ancillary therapeutic option in patients with uncontrolled resistant HTN confirmed by ambulatory blood pressure measurement and in spite of attention to lifestyle changes and optimised pharmacological treatment. Furthermore, RDN could alos be considered for patienst unlikley to adhere to or tolerate long-term antihypertensive drug treatment. Very recent data indicate long-term safety and efficacy up to 10 years. Appropriate implementation of RDN into clinical practice is now warranted.For all other interventions additional data from adequately designed human studies are required to establish their safety and clinical utility for potential future use in routine practice.
Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke: results of the prospective HEBRAS study
Authors: Hellwig Simon , Krause Thomas , Scheitz Jan F , Herm Juliane , Grittner Ulrike , Jauert Nadja , Fiebach Jochen B , Kasner Mario , Doehner Wolfram , Endres Matthias , Wachter Rolf , Elgeti Thomas , Nolte Christian H , Haeusler Karl Georg 
Published: June 2023

BackgroundStroke aetiology remains cryptogenic in a relevant proportion of patients with acute ischaemic stroke (AIS). We assessed whether enhanced diagnostic workup after AIS yields a higher rate of prespecified pathological findings compared with routine diagnostic care in-hospital.MethodsHospitalised patients with AIS were prospectively enrolled in the investigator-initiated observational HEart and BRain Interfaces in Acute Ischaemic Stroke (HEBRAS) study at the Charité, Berlin, Germany. Patients with AIS without known atrial fibrillation (AF) underwent cardiovascular MR imaging (CMR), MR-angiography of the aortic arch and prolonged Holter-ECG monitoring on top of routine diagnostic care.ResultsAmong 356 patients with AIS (mean age 66 years, 37.6% female), enhanced workup yielded a higher rate of prespecified pathological findings compared with routine care (17.7% vs 5.3%; p<0.001). Consequently, fewer patients were classified as cryptogenic after enhanced diagnostic workup (38.5% vs 45.5%, p<0.001). Routine care included echocardiography in 228 (64.0%) patients. CMR was successfully performed in 292 (82.0%) patients and revealed more often a prespecified pathological finding compared with routine echocardiography (16.1% vs 5.3%). Furthermore, study-related ECG monitoring (median duration 162 hours (IQR 98–210)) detected AF in 16 (4.5%) patients, while routine monitoring (median duration 51 hours (IQR 34–74)) detected AF in seven (2.0%) patients.ConclusionsEnhanced diagnostic workup revealed a higher rate of prespecified pathological findings in patients with AIS compared with routine diagnostic care and significantly reduced the proportion of patients with cryptogenic stroke.Trial registration numberNCT02142413.
Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex
Authors: Nyquist Michael D. , Coleman Ilsa M. , Lucas Jared M. , Li Dapei , Hanratty Brian , Meade Hannah , Mostaghel Elahe A. , Plymate Stephen R. , Corey Eva , Haffner Michael C. , Nelson Peter S. 
Published: June 2023

Abstract

The androgen receptor (AR) pathway regulates key cell survival programs in prostate epithelium. The AR represents a near-universal driver and therapeutic vulnerability in metastatic prostate cancer, and targeting AR has a remarkable therapeutic index. Though most approaches directed toward AR focus on inhibiting AR signaling, laboratory and now clinical data have shown that high dose, supraphysiological androgen treatment (SPA) results in growth repression and improved outcomes in subsets of patients with prostate cancer. A better understanding of the mechanisms contributing to SPA response and resistance could help guide patient selection and combination therapies to improve efficacy. To characterize SPA signaling, we integrated metrics of gene expression changes induced by SPA together with cistrome data and protein-interactomes. These analyses indicated that the dimerization partner, RB-like, E2F, and multivulval class B (DREAM) complex mediates growth repression and downregulation of E2F targets in response to SPA. Notably, prostate cancers with complete genomic loss of RB1 responded to SPA treatment, whereas loss of DREAM complex components such as RBL1/2 promoted resistance. Overexpression of MYC resulted in complete resistance to SPA and attenuated the SPA/AR-mediated repression of E2F target genes. These findings support a model of SPA-mediated growth repression that relies on the negative regulation of MYC by AR leading to repression of E2F1 signaling via the DREAM complex. The integrity of MYC signaling and DREAM complex assembly may consequently serve as determinants of SPA responses and as pathways mediating SPA resistance.

Significance:
Determining the molecular pathways by which supraphysiological androgens promote growth arrest and treatment responses in prostate cancer provides opportunities for biomarker-selected clinical trials and the development of strategies to augment responses.
Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma
Authors: Matsumoto Shinji , Harada Akikazu , Seta Minami , Akita Masayuki , Gon Hidetoshi , Fukumoto Takumi , Kikuchi Akira 
Published: June 2023

Abstract

Wnt signaling is known to maintain two cell states, hepatocyte differentiation and proliferation, in hepatocellular carcinoma (HCC). On the other hand, activation of Wnt signaling in colon cancer promotes uncontrollable stereotypic proliferation, whereas cells remain undifferentiated. To elucidate the unique mode of Wnt signaling in HCC, we comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1. Wnt signaling induced expression of GREB1 coupled with HNF4α and FOXA2, master transcription factors that maintain hepatic differentiation. Moreover, GREB1 was enriched at the regulatory region of atypical HNF4α target genes, including progrowth genes, thereby stimulating HCC proliferation. Therefore, GREB1 acts as a unique mediator of versatile Wnt signaling in HCC progression, bridging the roles of the Wnt pathway in differentiation and proliferation.

Significance:
GREB1 is a liver cancer–specific Wnt signaling target gene that induces an oncogenic shift of HNF4α, a putative tumor suppressor, and may represent a therapeutic target in Wnt-activated hepatocellular carcinoma.
Urine pH and Risk of Bladder Cancer in Northern New England
Authors: Fischer Alexander H. , Wong Jason Y.Y. , Baris Dalsu , Koutros Stella , Karagas Margaret R. , Schwenn Molly , Johnson Alison , Alguacil Juan , Silverman Debra T. , Rothman Nathaniel 
Published: June 2023

Abstract

Background:
Acidic urine pH is associated with rapid hydrolysis of N-glucuronide conjugates of aromatic amines into metabolites that may undergo metabolism in the bladder lumen to form mutagenic DNA adducts. We previously reported that consistently acidic urine was associated with increased bladder cancer risk in a hospital-based case–control study in Spain. Here, we conducted a separate study in northern New England to replicate these findings.

Methods:
In a large, population-based case–control study conducted in Maine, New Hampshire, and Vermont, we examined bladder cancer risk in relation to consistent urine pH, measured twice daily by participants over 4 consecutive days using dipsticks. In parallel, we collected spot urine samples and conducted laboratory measurements of urinary acidity using a pH meter. Unconditional logistic regression was used to estimate associations, adjusting for age, gender, race, Hispanic status, and state. Analyses were further stratified by smoking status.

Results:
Among 616 urothelial carcinoma cases and 897 controls, urine pH consistently ≤ 6.0 was associated with increased bladder cancer risk (OR = 1.27; 95% confidence interval, 1.02–1.57), with the effect limited to ever-smokers. These findings were supported by analyses of a spot urine, with statistically significant exposure–response relationships for bladder cancer risk overall (Ptrend = 5.1×10−3) and among ever-smokers (Ptrend = 1.2×10−3).

Conclusions:
Consistent with a previous study in Spain, our findings suggest that acidic urine pH is associated with increased bladder cancer risk.

Impact:
Our findings align with experimental results showing that acidic urine pH, which is partly modifiable by lifestyle factors, is linked to hydrolysis of acid-labile conjugates of carcinogenic aromatic amines.