bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of temozolomide on tumor mutation burden and microsatellite instability in melanoma cells
Authors: Sawada Masahide , Hida Tokimasa , Kamiya Takafumi , Minowa Tomoyuki , Kato Junji , Okura Masae , Idogawa Masashi , Tokino Takashi , Uhara Hisashi 
Published: September 2023

AbstractThe efficacy of combination therapy with an immune checkpoint inhibitor (ICI) and cytotoxic chemotherapeutic agents has been investigated in cancer, including melanoma. Before ICIs were introduced, dacarbazine or temozolomide (TMZ) were used to treat melanoma. Several studies using glioma or colorectal cancer cells showed that TMZ can increase the tumor mutation burden (TMB) and induce mismatch repair (MMR) deficiency associated with microsatellite instability (MSI). These could increase immunoreactivity to an ICI, but this has not been evaluated in melanoma cells. We investigated the effects of TMZ on MSI status and TMB in melanoma cells. To evaluate the TMB, we performed whole‐exome sequencing using genomic DNA from the human melanoma cell lines Mel18, A375, WM266‐4, G361, and TXM18 before and after TMZ treatment. Polymerase chain reaction amplification of five mononucleotide repeat markers, BAT25, BAT26, NR21, NR24, and MONO27, was performed, and we analyzed changes in the MSI status. In all cell lines, the TMB was increased after TMZ treatment (the change amount of TMB with ≤ 5% variant allele frequency [VAF] was 18.0–38.3 mutations per megabase) even in the condition without obvious cytological damage. MSI after TMZ treatment was not observed in any cells. TMZ increased TMB but did not change MSI status in melanoma cells.
Impact of coastal tourism demand on fisheries industry sustainability: A suggested framework for blue growth
Authors: Alsaleh Mohd , Wang Xiaohui , Nan Zhang , Liu Ru , Sun Qingru 
Published: September 2023

AbstractIntense use of coastal resources and construction of new marinas to expand the tourist industry might result in developing water and marine environmental quality due to pollution, noise, and species disturbance, harming aquatic ecosystems and fisheries. By considering the roles played by fisheries output, tourist development, energy input, economic growth, governance, and population density during 1990–2022, this research aims to explore the dynamic influence of tourism development on the sustainability of the fisheries sector in 27 European nations. The findings of this study, which used the new Method of Moments Quantile Regression (MMQR) with fixed variables, revealed a considerable adverse impact of energy consumption and tourist growth on the sustainability of fisheries across the EU27 area. In particular, the findings show that across all quantiles, the considerable adverse impact of tourist development on fisheries sustainability is more substantial in EU13 developing nations than in EU14 developed countries. At the same time, the findings show that the EU14 developed nations had a more significant negative impact on fisheries sustainability than the EU13 developing countries at the most recent quantiles. The relationship between governance (across all quantiles) and economic growth in the EU27 was also favorably significant. Notably, the findings show that the EU14 developed countries have a more substantial beneficial impact on fisheries sustainability than the EU13 developing nations. At medium quantiles, it was discovered that population density increased fisheries sustainability. Results show that population density has a more significant beneficial impact on fisheries sustainability in EU13 developing nations than in EU14 developed countries. To safeguard marine ecosystems and achieve sustainable blue growth, our results provide policymakers insight into how to support coastal tourism development in EU14 and EU13 nations using effective and environmentally friendly resources and technology.
Prevalence of xylazine in overdose cases: An analysis of Miami‐Dade County medical examiner case data
Authors: Potoukian Rocio B. , Gonyea Jennifer , Shoff Elisa N. , Hime George W. , Moore Diane M. 
Published: September 2023

AbstractXylazine sedative, muscle relaxant, and analgesic used in a veterinary setting. Although xylazine was never approved for therapeutic use in humans, it has become popular in the street drug market as a cutting or bulking agent in the fentanyl and heroin supply. Recently, there has been a significant increase in the detection of xylazine in postmortem forensic toxicology casework. Xylazine can be identified during routine toxicology screening utilizing instrumentation such as gas chromatography–mass spectrometry and liquid chromatography–mass spectrometry. Using the Miami‐Dade Medical Examiner's LIMS system, all cases received between 2015 and 2022 in which xylazine was reported were reviewed. The cases studied include accidental drug overdose deaths in Miami‐Dade County as well as Collier County (Naples), Florida. In total, there are 170 cases; the majority are accidental polydrug overdoses involving White males between the ages of 25 and 44 years old. Of the 170 cases, 37% listed xylazine as the cause of death. 13% of cases contained only xylazine and fentanyl while the remaining 87% of deaths were attributed to polydrug toxicity involving two or more substances. The prevalence of xylazine can be attributed to its increasing popularity rather than an increase in caseload. In 2019, xylazine was present in only 4% of all accidental fentanyl overdoses. By 2021, this percentage has increased sixfold, with xylazine present in 24% of all accidental fentanyl overdoses. Despite a decrease in fentanyl overdoses in 2022, the percentage of xylazine detection remained the same.
En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report
Authors: Qin Changlong , Xia Qinghong , Chen Zi‐Jia , Zhou Qinghua , Zheng Xi 
Published: September 2023

AbstractMalignant pleural mesothelioma (MPM) is associated with previous asbestos exposure, while more clinical insights into this disease have come from other case studies. Maximal cytoreduction is critical in disease control and might help to improve the prognosis. Here, a 41‐year‐old female presented with a 6‐month history of a mass detected in the chest wall following resection of a right pleural mesothelioma 2 years previously. A fluorodeoxyglucose positron emission tomography/computed tomography scan showed a right chest wall mass with a blurred boundary 8.9 cm × 3.7 cm in size. The patient had received one cycle of bevacizumab, carboplatin, and pemetrexed, and two cycles of nivolumab, ipilimumab, and gemcitabine 5 months before admission. We subsequently resected the tumor, the involved diaphragm, and the fifth and sixth ribs, and titanium mesh and continuous suture were used to close the thoracic cage. The fixed paraffin‐embedded tissues showed epithelioid pleural mesothelioma. The patient received nivolumab and ipilimumab postoperatively, and no recurrence was detected 16 months after surgery. En bloc resection with reconstructive surgery effectively removed the locally advanced malignancy and restored the biological function of the thorax with a favorable prognosis. Neoadjuvant immunotherapy might therefore be conducive to radical resection and perioperative immunotherapy might improve the prognosis.
Behavioural self‐control training versus motivational enhancement therapy for individuals with alcohol use disorder with a goal of controlled drinking: A randomized controlled trial
Authors: Hammarberg Stina Ingesson , Wallhed Finn Sara , Rosendahl Ingvar , Andréasson Sven , Jayaram‐Lindström Nitya , Hammarberg Anders 
Published: September 2023

AbstractBackground and aimsControlled drinking (CD) is an attractive treatment goal for a large proportion of individuals with alcohol use disorder (AUD), but the availability of treatment methods supporting a goal of CD is scarce. We tested if behavioural self‐control training (BSCT) was superior to motivational enhancement therapy (MET) for individuals with AUD with a treatment goal of CD.DesignRandomized controlled two‐group trial. Follow‐ups were conducted at 12 and 26 weeks (primary end‐point) after inclusion.SettingThree specialized dependency care clinics in Stockholm, Sweden.ParticipantsTwo hundred and fifty self‐referred adults (52% men) fulfilling criteria of AUD (DSM‐5) and a stated treatment goal of CD.Intervention and comparatorBSCT (n = 125), a five‐session treatment based on cognitive behavioural therapy versus the active comparator, MET (n = 125), containing four sessions based on Motivational Interviewing.MeasurementsPrimary outcome measure was mean weekly alcohol consumption at the 26‐week follow‐up, adjusted for baseline consumption.ConclusionsA randomized controlled trial found no evidence of a difference between behavioural self‐control training and motivational enhancement therapy in reducing weekly alcohol consumption. Both groups substantially reduced consumption and behavioural self‐control training was superior in reducing hazardous drinking.
Craving modulates attentional bias towards alcohol in severe alcohol use disorder: An eye‐tracking study
Authors: Bollen Zoé , Pabst Arthur , Masson Nicolas , Wiers Reinout W. , Field Matt , Maurage Pierre 
Published: September 2023

AbstractBackground and aimsCompeting models disagree on three theoretical questions regarding alcohol‐related attentional bias (AB), a key process in severe alcohol use disorder (SAUD): (1) is AB more of a trait (fixed, associated with alcohol use severity) or state (fluid, associated with momentary craving states) characteristic of SAUD; (2) does AB purely reflect the over‐activation of the reflexive/reward system or is it also influenced by the activity of the reflective/control system and (3) does AB rely upon early or later processing stages? We addressed these issues by investigating the time‐course of AB and its modulation by subjective craving and cognitive load in SAUD.DesignA free‐viewing eye‐tracking task, presenting pictures of alcoholic and non‐alcoholic beverages, combined with a concurrent cognitive task with three difficulty levels.SettingA laboratory setting in the detoxification units of three Belgian hospitals.ParticipantsWe included 30 patients with SAUD self‐reporting craving at testing time, 30 patients with SAUD reporting a total absence of craving and 30 controls matched on sex and age. All participants from SAUD groups met the DSM‐5 criteria for SAUD.MeasurementsWe assessed AB through early and late eye‐tracking indices. We evaluated the modulation of AB by craving (comparison between patients with/without craving) and cognitive load (variation of AB with the difficulty level of the concurrent task).FindingsDwell time measure indicated that SAUD patients with craving allocated more attention towards alcohol‐related stimuli than patients without craving (P < 0.001, d = 1.093), resulting in opposite approach/avoidance AB according to craving presence/absence. SAUD patients without craving showed a stronger avoidance AB than controls (P = 0.003, d = 0.806). AB did not vary according to cognitive load (P = 0.962, η2p = 0.004).ConclusionsThe direction of alcohol‐related attentional bias (approach/avoidance) appears to be determined by patients' subjective craving at testing time and does not function as a stable trait of severe alcohol use disorder. Alcohol‐related attentional bias appears to rely on later/controlled attentional stages but is not modulated by the saturation of the reflective/control system.
Rare but not lost: Endemic mountain lizard occupancy following megafire and grazing disturbances
Authors: Hartley Renée , Blanchard Wade , Clemann Nick , Schroder Mel , Schulz Martin , Lindenmayer David B. , Scheele Ben C. 
Published: September 2023

AbstractWildfire and grazing by invasive herbivores can influence habitat suitability for ground‐dwelling fauna, such as reptiles. Australia has a large and diverse reptile fauna, with the Australian Alps bioregion in the southeast of the continent supporting a disproportionately high number of threatened species. In this bioregion, many species are threatened by fire, habitat loss or modification, and invasive species. The range of one such threatened endemic lizard, Cyclodomorphus praealtus (family Scincidae), was impacted by the 2019–20 megafires and is also subject to widespread grazing by invasive species. We investigated the relationship between C. praealtus site occupancy and fire and grazing. We completed 2045 surveys across 120 sites over 4 years, detecting the species at 43% of sites and increasing the species' known geographic range. Using single season detection occupancy models, we found C. praealtus occupancy was not associated with elevation, vegetation height or whether the site was burnt, but was positively associated with grazing activity. Our results indicate that C. praealtus has the capacity to persist following a single fire in some cases, and that habitats with high occupancy probabilities are subject to high grazing pressure. However, our results do not rule out more nuanced impacts associated with these disturbances, which affect a large proportion of C. praealtus' habitat. Our cumulative detection probability calculations revealed that considerable survey effort is often required to determine C. praealtus site occupancy. We therefore recommend that impact assessments assume species presence within areas of suitable habitat within the species' range. Our study improves our understanding of disturbance impacts on C. praealtus' occupancy, while demonstrating the need for sufficiently resourced impact assessments for cryptic and threatened species.
Gill arch and raker morphology of common carp (Cyprinus carpio, Linnaeus, 1758) sampled in aquaculture system
Authors: Demirci Beste , Kesbiç Osman Sabri 
Published: September 2023

AbstractThe study aimed to investigate the morphologic aspects of common carp's gill arch and gill rakers (Cyprinus carpio, Linnaeus, 1758), an omnivore and highest‐produced aquaculture species. The study used 10 common carp (395.35 ± 45.06 g) grown entirely under aquaculture conditions. The fish tissues were fixed with Glutaraldehyde (2.5%) for scanning electron microscopy and with formalin (10%) for stereomicroscopic examination. In the SEM examination, two types of taste papillae (Type II and Type III) were observed in the pharyngeal mucosa. Microridge‐like structures in the epithelial layer were found to have two forms. The study findings indicate a significant decrease in gill arch lengths from cranial to caudal and a significant increase in rakers per unit area, as determined through digital calliper measurements and stereomicroscopic examinations (p < 0.05). However, there was no significant difference in measurements of gill arches and raker numbers between the bilateral symmetry of the gill arches (p > 0.05). In conclusion, it was observed that the epithelial structure on the common carp gill arch contained two types of microridge‐like structures: the gill arch length decreased from cranial to caudal, and the rake density on these arches increased caudally.
After migration: An ethnographic exploration of the mindwork of stuckness
Authors: Dantzer Alexandra 
Published: September 2023

SummaryIn this essay, I follow the migration journey of a young middle‐class woman migrating from Serbia to Germany. I explore the existential condition of stuckness that she reports as a continuous impasse throughout various stages of her migration career. By focusing on her migration contradiction, I survey the intimate temporalities brought about by being stuck differently in changing contexts.
What happens at work does not always stay at work: Daily job crafting and detachment among colleagues
Authors: Sanz‐Vergel Ana Isabel , Nielsen Karina , Rodríguez‐Muñoz Alfredo , Antino Mirko 
Published: September 2023

AbstractThrough job crafting, employees proactively change or modify their tasks, thus reducing adverse job demands or protecting resources. There is still a lack of understanding of the impact that job crafting may have on colleagues at work (crossover effect), and how this may affect their ability to disconnect from work (spillover effect). In the present daily diary study, we examine these two processes among 82 dyads of colleagues (N = 164 employees) over five consecutive working days (N = 820 observations). We found a number of crossover and differential spillover effects. For example, when the focal employee starts new challenging projects, their colleague reacts by reducing the number of stressful tasks. This, in turn, affects psychological detachment from work. Specifically, whereas increasing challenging demands hinders daily detachment, decreasing hindering demands facilitates it. Taken together, these findings demonstrate that the impact of job crafting goes beyond the focal employee and beyond the work domain.
Editorial: the microscope holds the key to predict need for biologic therapy in immunotherapy‐checkpoint inhibitor colitis
Authors: Buckle Andrew D. , Christensen Britt 
Published: September 2023

LINKED CONTENTThis article is linked to Pai et al papers. To view these articles, visit https://doi.org/10.1111/apt.16142 and https://doi.org/10.1111/apt.16245
Letter: is female sex really associated with better prognosis in hepatocellular carcinoma?
Authors: Pelizzaro Filippo , Penzo Barbara , Trevisani Franco , Farinati Fabio ,   the Italian Liver Cancer (ITA.LI.CA) study group
Published: September 2023

LINKED CONTENTThis article is linked to Rich et al paper. To view this article, visit https://doi.org/10.1111/apt.15917
Transmural healing and MRI healing are associated with lower risk of bowel damage progression than endoscopic mucosal healing in Crohn’s disease
Authors: Lafeuille Pierre , Hordonneau Constance , Vignette Jeanne , Blayac Laurianne , Dapoigny Michel , Reymond Maud , Rouquette Olivier , Sollelis Elisa , Boube Mathilde , Magnin Benoit , Pereira Bruno , Buisson Anthony 
Published: September 2023

SummaryBackgroundEndoscopic mucosal healing is the current therapeutic target in Crohn's disease. However, transmural healing could lead to better outcomes.AimsTo assess whether transmural healing or magnetic resonance imaging (MRI) healing are better therapeutic targets than endoscopic mucosal healing to predict long‐term improved outcome in Crohn's diseaseMethodsFrom our MRI database, we retrospectively identified all Crohn's disease patients who had MRI and colonoscopy within a 3‐month interval (median interval = 17.5 days). Four groups were considered: endoscopic mucosal healing (no ulceration or aphthoid erosion), MRI healing (no MRI signs of inflammation and no complication), transmural healing (combination of endoscopic and MRI healing) or no healing. Outcomes were time to surgery, bowel damage progression, hospitalisation, major outcomes (one of the three previous endpoints) and Crohn's disease‐related drug discontinuation. Results were expressed in multivariable analyses adjusted on potential confounders (hazard ratio (HR) [95% confidence interval]).ResultsAmong 154 patients with Crohn's disease, 51.9% (80/154), 10.4% (16/154), 19.5% (30/154) and 18.2% (28/154) achieved no healing, endoscopic mucosal healing, MRI healing and transmural healing, respectively. Transmural healing (HR = 0.05 [0.00‐0.40], P = 0.002) and MRI healing (HR = 0.09 [0.00‐0.47], P = 0.005) were associated with lower risk of bowel damage progression than endoscopic mucosal healing. In addition, achieving transmural healing or MRI healing reduced the risk of experiencing major outcomes compared to endoscopic mucosal healing (HR = 0.28 [0.00‐0.74], P = 0.01). Patients with transmural healing also had a decreased risk of relapse‐related drug discontinuation (HR = 0.35 [0.13‐0.95], P = 0.039) compared to those with endoscopic mucosal healing.ConclusionTransmural healing and MRI healing are associated with lower risk of bowel damage progression than endoscopic mucosal healing and could be considered as better therapeutic targets in Crohn's disease.
Editorial: similar risk of hepatocellar carcinoma in chronic hepatitis B patients treated with tenofovir or entecavir—new clues from Europe
Authors: Lampertico Pietro , Papatheodoridis George V. 
Published: September 2023

LINKED CONTENTThis article is linked to Pol et al papers. To view these articles, visit https://doi.org/10.1111/apt.16197 and https://doi.org/10.1111/apt.16251
Impact of proton pump inhibitors on cytochrome P450 activity assessed by 13C‐aminopyrine breath test in patients with cirrhosis
Authors: Rocco Alba , Compare Debora , Sgamato Costantino , Coccoli Pietro , Chiodini Paolo , Nardone Gerardo 
Published: September 2023

SummaryBackgroundChronic use of proton pump inhibitors (PPIs) in patients with impaired liver function may worsen cytochrome P450 (CYP450) activity, predisposing them to clinically relevant drug–drug interactions. The 13C‐aminopyrine breath test (13C‐ABT) is a non‐invasive tool to study CYP450‐dependent liver function.AimsTo assess 13C‐ABT modifications with different PPIs in patients with cirrhosisMethodsSixty consecutive patients with HCV‐related cirrhosis and indication to start PPI therapy were randomised to receive omeprazole 20 mg/day, esomeprazole 20 mg/day, lansoprazole 15 mg/day, pantoprazole 40 mg/day or rabeprazole 20 mg/day. 13C‐ABT was performed at baseline and on the 15th day of PPI therapy.ResultsAt baseline, mean values of max 13C% dose/h and 13C% cum dose at 120 minutes did not differ significantly among groups. On the 15th day of therapy, max 13C% dose/h and 13C% cum dose at 120 minutes did not significantly differ with respect to baseline for pantoprazole (P = 0.184 and P = 0.309, respectively) or rabeprazole (P = 0.536 and P = 0.286, respectively), but were significantly decreased on omeprazole (P = 0.013 and P = 0.015, respectively), esomeprazole (P = 0.009 and P = 0.001, respectively), and lansoprazole (P = 0.033 and P = 0.035, respectively).ConclusionsIn patients with cirrhosis, omeprazole, esomeprazole and lansoprazole inhibit microsomal activity while pantoprazole and rabeprazole do not have a significant impact. Should our data be confirmed in larger cohort studies, pantoprazole and rabeprazole could be safely recommended for patients with cirrhosis.
Editorial: anti‐TNF agents against vedolizumab as a second‐line treatment? Not surprising tie game—authors’ reply
Authors: Rundquist Sara , Sachs Michael C. , Eriksson Carl , Olén Ola , Montgomery Scott , Halfvarson Jonas 
Published: September 2023

LINKED CONTENTThis article is linked to Rundquist et al and Roblin et al. papers. To view these articles, visit https://doi.org/10.1111/apt.16193 and https://doi.org/10.1111/apt.16212
Editorial: the microscope holds the key to predict need for biologic therapy in immunotherapy‐checkpoint inhibitory colitis. Authors' reply
Authors: Pai Rish K. , Pai Reetesh K. , Schaeffer David F. , Choi Won‐Tak , Kumarasinghe Priyanthi , Brown Ian , Lauwers Gregory Y. 
Published: September 2023

LINKED CONTENTThis article is linked to Pai et al and Buckle & Christensen papers. To view these articles, visit https://doi.org/10.1111/apt.16142 and https://doi.org/10.1111/apt.16203
Editorial: towards an understanding of increased mortality in coeliac disease—authors' reply
Authors: Schneider Carolin V. , Strnad Pavel 
Published: September 2023

LINKED CONTENTThis article is linked to Schneider et al and Anderson papers. To view these articles, visit https://doi.org/10.1111/apt.16206 and https://doi.org/10.1111/apt.16237
Editorial: will clusters for anxiety, depression, sleep disturbance and fatigue symptoms predict treatment outcomes in functional dyspepsia? Authors' reply
Authors: Barberio Brigida , Black Christopher J. , Ford Alexander C. 
Published: September 2023

LINKED CONTENTThis article is linked to Barberio et al and van Zanten papers. To view these articles, visithttps://doi.org/10.1111/apt.16184andhttps://doi.org/10.1111/apt.16235