bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of glaucoma genes in Finnish patients with juvenile open‐angle glaucoma
Authors: Liuska Perttu J. , Tadji Abdessallam , Repo Pauliina , Hiltunen Juho , Backlund Michael , Järvinen Reetta‐Stiina , Ojanen Eeva , Majander Anna , Kivelä Tero T. , Harju Mika , Turunen Joni A. 
Published: April 2023

AbstractPurposeTo identify germline variants in myocilin (MYOC) and other known monogenic glaucoma genes in Finnish patients with juvenile open‐angle glaucoma (JOAG).MethodsFinnish patients with JOAG treated between 2010 and 2018 at the Department of Ophthalmology, Helsinki University Hospital, Finland, were enrolled. We sequenced all exonic regions and flanking splice sites of MYOC for five patients and one healthy relative using Sanger sequencing. In 48 patients, we performed exome sequencing to identify variants also in 28 other glaucoma‐related genes.ResultsFifty‐three individuals with JOAG from 50 pedigrees, and one healthy relative, participated. The mean age at diagnosis was 30.8 years [SD 7.6; range 11 to 39]. Five probands had probably pathogenic variants in MYOC: c.1102C>T p.(Gln368Ter), c.1109C>T p.(Pro370Leu), c.1130C>T p.(Thr377Met), c.1132G>A p.(Asp378Asn) and c.1456C>T p.(Leu486Phe). Four of these patients had a family history of dominantly inherited JOAG. The frequency of MYOC variants was 10% (5 of 50 families). One patient and his mother with JOAG had a novel loss‐of‐function variant in the FOXC1 gene, c.366G>A p.(Trp122Ter). A patient with sporadic JOAG had a homozygous likely pathogenic variant in the LTBP2 gene, c.3938G>A p.(Cys1313Tyr). The genetic variants explained 14% (7 out of 50 families; 95% CI, 6%–23%) of JOAG in our cohort.ConclusionsThe frequency of pathogenic variants in previously known glaucoma‐associated genes is low in Finnish patients with JOAG. Because of the distinct genetic background of Finns, it might be possible to identify novel glaucoma genes through our JOAG series in the future.
Aberrant voxel‐based degree centrality and functional connectivity in Parkinson's disease patients with fatigue
Authors: Shan Aidi , Zhang Heng , Gao Mengxi , Wang Lina , Cao Xingyue , Gan Caiting , Sun Huimin , Yuan Yongsheng , Zhang Kezhong 
Published: April 2023

AbstractAimsThe study aimed to investigate alterations in the inherent connectivity pattern of global functional networks in Parkinson's disease (PD) patients with fatigue.MethodsEighteen PD patients with fatigue (PD‐F), 20 PD patients without fatigue (PD‐NF), and 23 healthy controls (HCs) were recruited and analyzed by the voxel‐wise degree centrality (DC) and the seed‐based functional connectivity (FC) analysis. Meanwhile, the surface‐based morphometry (SBM) analysis was also commanded to explore the structural alternations among groups.ResultsPD‐F patients displayed reduced DC values in the left postcentral gyrus relative to PD‐NF and HCs groups, while increased DC values in the bilateral precuneus compared to HCs. Simultaneously, altered DC value in the left postcentral gyrus negatively corresponded to the mean fatigue severity scale (FSS) in PD‐F patients. Additionally, the receiver operating characteristic (ROC) curves uncovered that the reduced DC value of the left postcentral gyrus could discriminate PD‐F from PD‐NF and HCs groups. Our FC analysis further revealed that altered FC was located predominantly in the sensorimotor network in the PD‐F group. Moreover, we discovered no statistically significant differences between the three groups concerning cortical thickness.ConclusionOur findings indicated that the altered functional connectivity in the sensorimotor network centering on the left postcentral gyrus and the bilateral precuneus might be the potential pathogenesis of PD with fatigue.
Emperor goose fall–winter harvest monitoring and hunter's perspectives in Alaska
Authors: Naves Liliana C. , Schamber Jason L. , Mengak Lara F. , Keating Jacqueline M. , Fall James A. 
Published: April 2023

AbstractMonitoring harvests and understanding hunters' perspectives are key for effective harvest management. Emperor goose (Anser canagicus)harvest in Alaska was recently re‐authorized after a 30‐year closure, but relatively small numbers of geese are available for a sustainable harvest. We characterized participation in the fall–winter hunting permit program, evaluated harvest monitoring, documented hunter's perspectives, and provided management recommendations. Participants in fall–winter bird hunting include rural, urban, Alaska Native, non‐Indigenous, subsistence, and sport (recreational) hunters, and these categories may overlap. In 2017–2019, 1367 permits were issued to urban Alaska residents (49%), rural residents (47%), and nonresidents (4%). Permit reporting documented take below the fall–winter federal quota. However, ancillary harvest surveys in rural Alaska suggested a substantially higher harvest. In a survey of 2017 and 2018 permit holders, most Alaska urban and nonresident respondents as well as more than half of rural respondents identified sport hunting as their primary motivation for obtaining a permit. These respondents often mentioned a taxidermy mount as a reason for obtaining a permit. About half of respondents motivated by subsistence hunting mentioned food as a reason. Finetuning harvest management include actions to increase participation by rural hunters in the fall–winter permit program, adjustments to boundaries of hunt areas so they are meaningful for hunters, and complementary harvest monitoring for all regulatory seasons.
Cost‐effectiveness analysis of once‐daily insulin glargine 300 U/mL versus insulin degludec 100 U/mL using the BRAVO diabetes model
Authors: Shao Hui , Shi Lizheng , Fonseca Vivian , Alsaleh Abdul Jabbar Omar , Gill Jasvinder , Nicholls Charlie 
Published: April 2023

AbstractAimsA cost‐effectiveness analysis was conducted to compare insulin glargine 300 U/mL (Gla‐300) versus insulin degludec 100 U/mL (IDeg‐100) in insulin‐naïve adults with type 2 diabetes (T2D) sub‐optimally controlled with oral anti‐diabetic drugs (OADs).MethodsThe BRAVO diabetes model was used to assess costs and outcomes for once‐daily Gla‐300 versus once‐daily IDeg‐100 from a US healthcare sector perspective. Baseline clinical data were based on BRIGHT, a 24‐week, non‐inferiority, randomised control trial comparing Gla‐300 and IDeg‐100 in adults with T2D sub‐optimally controlled with OADs (with or without glucagon‐like peptide‐1 receptor agonists). Treatment costs were based on doses observed in BRIGHT as well as net prices. Costs associated with complications were based on published literature. Lifetime costs (US$) and quality‐adjusted life‐years (QALYs) were predicted and used to calculate incremental cost‐effectiveness ratio estimates; extensive scenario and sensitivity analyses were conducted.ResultsOverall lifetime medical costs were estimated to be $327,904 and $330,154 for people receiving Gla‐300 and IDeg‐100, respectively; insulin costs were $43,477 and $44,367, respectively. People receiving Gla‐300 gained 8.024 QALYs and 18.55 life‐years, while people receiving IDeg‐100 gained 7.997 QALYs and 18.52 life‐years. Because Gla‐300 was associated with a cost‐saving of $2250 and 0.027 additional QALYs, it was considered to be dominant compared with IDeg‐100. Results of the scenario and sensitivity analyses confirmed the robustness of the base case results.ConclusionGla‐300 was the dominant treatment option compared with IDeg‐100 based on the willingness‐to‐pay threshold of $50,000/QALY. Results remained robust against a wide range of alternative assumptions on key parameters.
Evaluating the Melbourne Strategic Assessment—Elegant on process, currently failing on implementation
Authors: Lowe Kim W , Wescott Geoffrey 
Published: April 2023

SummaryThis paper provides a critical analysis of the development and current outcomes of Australia's first endorsed strategic assessment under the Environment Protection and Biodiversity Conservation Act 1999, namely, the Melbourne Strategic Assessment. It covers progress towards protection of a number of Nationally Significant Species and Ecological Communities – most notably, the native grassland communities immediately adjacent to Melbourne's Urban Growth Boundary. The Commonwealth approval to protect biodiversity and allow urban development was made in 2010 and it aimed to achieve its outcomes by 2020. These outcomes included providing new land for homes, for new transport corridors, and for conservation of biodiversity. Natural Temperate Grassland (4,667 ha), Grassy Eucalypt Woodland (709 ha) and seven other Matters of National Environmental Significance will be impacted. Mitigation for this is establishment of 15,000 ha of grassland reserves, 1,200 ha of grassy woodland reserves, over 4,000 ha of other land zoned for conservation and 300 ha of wetland restoration. We conclude that the Melbourne Strategic Assessment has been a success in terms of the elegance and comprehensiveness of the approach, in cooperation between the levels of government, in the economic benefits, and in some aspects of social engagement of the agreement. However, the achievement of environmental outcomes must be currently considered a failure due to poor implementation. This failure includes not meeting the agreed 10 year deadline for land acquisition and management, poor monitoring and protection of set‐aside areas, and in reporting. We offer suggestions for how these current shortcomings could be overcome. These align well with the recommendations of the review of the Environment Protection and Biodiversity Conservation Act 1999 (The independent statutory review of the Act in 2020) and include the establishment of the proposed Office of Compliance and Enforcement, the adoption of National Environmental Standards and the reforms regarding the role of Indigenous Australians in strategic assessments. If these were adopted, we conclude that the strategic assessment approach should be more widely used because of the more holistic approach and efficiencies that it envisages compared with site by site approaches.
Exploring dental treatment decision‐making experiences of people living with dementia and family carers
Authors: Geddis‐Regan Andrew , Wassall Rebecca R. , Abley Clare , Exley Catherine 
Published: April 2023

IntroductionPeople living with dementia can have complex dental care needs. Dentists and patients should make treatment decisions together, yet some people living with dementia may be unable to make their own decisions about their dental care. Dental treatment decision‐making and patients' experiences of this process have not been comprehensively researched.ObjectiveThis study aimed to explore the dental treatment decision‐making perspectives and experiences of people living with dementia and their family members.MethodsSemi‐structured interviews were undertaken with 8 people living with dementia and 17 family caregivers. A constructivist grounded theory approach was adopted, using a maximum variation sample. Qualitative data collection and analysis occurred concurrently. Data underwent initial open coding followed by more focused coding, supported by reflexive memo writing, which supported data categorisation.ResultsPeople living with dementia reported wanting to be understood as unique individuals with specific needs. All participants described wanting to be actively involved in dental treatment decisions. However, many felt that they were insufficiently involved in treatment decision‐making. This perceived underinvolvement meant that some people living with dementia and family members felt the treatment outcomes they sought were neither discussed nor considered.ConclusionPeople living with dementia and carers had specific expectations of dental care yet felt passive in decision‐making despite their desire to be involved in this process. Dentists should seek to actively establish patients' preferences, regardless of mental capacity and consider these in discussions and decisions about dental treatment.
Fremanezumab plus plasmapheresis in a patient with chronic migraine and myasthenia gravis: Case report of an effective treatment
Authors: Carmillo Laura , Fasano Antonio 
Published: April 2023

AbstractA patient with chronic migraine and generalized myasthenia gravis was concurrently treated with fremanezumab and with therapeutic plasmapheresis (PEX). Fremanezumab was dosed right after a PEX session, or in the midpoint between sessions, and the efficacy of both treatments was maintained. This case broadens the drug's clinical applications and it helps in choosing the appropriate medical regimen in patients requiring both treatments.
Emotions and consumer behaviour: A review and research agenda
Authors: Sharma Kirti , Trott Sangeeta , Sahadev Sunil , Singh Ramendra 
Published: April 2023

AbstractConsumers' emotions play a salient role in consumers' buying process, their consumption behaviours, and their engagement with product/service offerings, owing to which, it has gained much attention in recent years as an area of inquiry. However, literature in this field/subject is theoretically fragmented. Therefore, to enhance the conceptual understanding, this study synthesizes extant literature, using a hybrid review approach. Herein, we attempt to integrate bibliometric analysis, along with the theories, contexts, characteristics, and methodology framework, while consolidating and classifying the domain knowledge, trends, and progress/citation analysis using the bibliometric approach. In the process, we reviewed 384 conceptual and empirical articles, published during the period 1967–2021. The idea was to identify key theories, constructs, research contexts, and methods, based on which, we propose a few potential research areas. Based on our thorough analysis, these areas include (1) consumer co‐creation, (2) consumer engagement, (3) service employee interactions, (4) consumer decision making, and (5) consumption experience.
Modulation of immunity by the secreted phospholipase A2 family
Authors: Murakami Makoto , Sato Hiroyasu , Taketomi Yoshitaka 
Published: April 2023

SummaryAmong the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2 hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) family contains 11 isoforms in mammals. Individual sPLA2s have unique enzymatic specificity toward fatty acids and polar heads of phospholipid substrates and display distinct tissue/cellular distributions, suggesting their distinct physiological functions. Recent studies using knockout and/or transgenic mice for a full set of sPLA2s have revealed their roles in modulation of immunity and related disorders. Application of mass spectrometric lipidomics to these mice has enabled to identify target substrates and products of individual sPLA2s in given tissue microenvironments. sPLA2s hydrolyze not only phospholipids in the plasma membrane of activated, damaged or dying mammalian cells, but also extracellular phospholipids such as those in extracellular vesicles, microbe membranes, lipoproteins, surfactants, and dietary phospholipids, thereby exacerbating or ameliorating various diseases. The actions of sPLA2s are dependent on, or independent of, the generation of fatty acid‐ or lysophospholipid‐derived lipid mediators according to the pathophysiological contexts. In this review, we make an overview of our current understanding of the roles of individual sPLA2s in various immune responses and associated diseases.
Mental Health Nurses' attitudes towards mental illness and recovery‐oriented practice in acute inpatient psychiatric units: A non‐participant observation study
Authors: Sreeram Anju , Cross Wendy M. , Townsin Louise 
Published: April 2023

AbstractNational mental health policies accentuate the importance of having positive attitudes, skills, and knowledge among mental health professionals to facilitate recovery‐oriented practices in all areas of mental health care. However, evidence suggests that mental health professionals' negative attitudes towards mental illness are still evident and that recovery‐oriented practice in acute inpatient units may be poorly implemented. At the same time, there is also a paucity of research to understand Mental Health Nurses' attitudes towards mental illness and recovery‐oriented practice specifically. Therefore, this non‐participant observation study aimed to explore Mental Health Nurses' attitudes towards mental illness and recovery‐oriented practice in acute inpatient units by observing the interactions between the consumers and nurses. The Mental Illness Clinicians Attitudes Scale‐v4 and The Recovery Attitudes Questionnaire inspired the development of a non‐participant observation chart for this study and the observations were recorded on the chart. Six observations were conducted in three acute inpatient units. Observations focused on Mental Health Nurses' knowledge about mental illness, communication, dignity, respect, anxiety, fear, punishment, facilitation of real choices for consumers, physical care, cooperation with consumers' families and others and recovery orientation. Interpretive descriptive analysis was used to analyse the data. The results show that Mental Health Nurses generally have positive attitudes towards mental illness and recovery‐oriented practice. Some deficits in the physical care of people with mental illness in the acute inpatient units were observed. Therefore, future research could address the adequate preparation of Mental Health Nurses to provide physical care to people with mental illnesses.
Value of blockchain‐enabled supply chain traceability under competition
Authors: Zhou Yu , Gao Xiang , Nie Jiajia 
Published: April 2023

AbstractIn a modern supply chain, the quality of the final product is not determined by a single firm but depends on the joint efforts of multiple firms. When a quality defect happens, it is usually cost‐inefficient to trace the source of quality problems and all firms in the supply chain might incur a loss. New technologies such as blockchain can enable supply chain traceability at an affordable cost. In this paper, we develop a two‐echelon supply chain model including one supplier and one buyer in a competitive market. The quality of the final product depends on the two firms’ quality efforts. The buyer as a leader can set a wholesale price to stimulate the supplier's effort. In the absence (presence) of traceability, the payment of wholesale price is based on the realization of the final product's quality (the supplier's individual quality). Interestingly, we find that supply chain traceability may cause a decrease of the supplier's quality effort, thereby reducing the quality of the final product when market competition is sufficiently intensive. Furthermore, traceability weakly increases the supplier's profit but weakly decreases the buyer's profit. However, the total profit of the supply chain can be increased in the presence of traceability.
Cell cycle arrest: A breakthrough in the supportive care of older cancer patients
Authors: Falandry Claire , List Alan , Balducci Lodovico 
Published: April 2023

AbstractBackgroundAge is a major risk factor for the acute and chronic complications of cancer chemotherapy. The current approach to the prevention of these complications is reactive and involves the reduction of the doses and the delay of treatment which may compromise the outcome. There is a limited number of antidotes to chemotherapy toxicity and these have complications of their own. Oldest old and frail patients are mostly excluded from life saving cancer treatment due to the risk of severe and even lethal complications.Methodsmolecular biology has revealed that different checkpoints control the proliferative cycle of normal and neoplastic cells. Two new drugs, Trilaciclib and ALRN‐6924 may cause a temporary cell cycle arrest (CCA) of normal cells without blocking the proliferation of the neoplastic ones and render the normal cells temporarily invulnerable to the toxicity of chemotherapy. We reviewed the publications related to these drugs on the Medline, the published drug information and the presentations to major medical conferences.ResultsIn three randomized controlled phase II trials Trilaciclib proved effective in preventing neutropenia, thrombocytopenia and anemia in patients with non small cell lung cancer with non proficient RB1 gene. Forty‐five percent of patients were 65 and older and age did not prevent the effectiveness of the drug. Trilaciclib was approved by the FDA for the management of these patients. ALRN‐6924 appeared promising in preventing myelotoxicity in patients whose cancer had deleted or mutated TP53, but failed to show any significant activity in a randomized controlled study. The development of this drug is now on holdConclusionsCCA is a novel proactive approach to the toxicity of chemotherapy of special interest to older patients. At the very least it may prevent all forms of myelotoxicity with a single agent, obviating the risk and cost of polypharmacy. It allows to avoid the complications of myelopoietic growth factors which include severe pain, stem cell competition, bone marrow exhaustion, and hematological malignancies. It may allow the treatment of frail patients with full chemotherapy doses. It is also reasonable to expect that may complications other common and sometimes lethal complications of chemotherapy such as stomatitis, esophagitis, diarrhea and dehydration.
What helps patients to prepare for and cope during awake craniotomy? A prospective qualitative study
Authors: Bala Aleksandra , Olejnik Agnieszka , Dziedzic Tomasz , Piwowarska Jolanta , Podgórska Anna , Marchel Andrzej 
Published: April 2023

AbstractThere is growing interest in awake craniotomies, but some clinicians are concerned that such procedures are poorly tolerated by patients. Therefore, we conducted a study to assess this phenomenon. In this prospective qualitative study, 68 patients who qualified for awake craniotomy were asked to complete the Hospital Anxiety and Depression Scale (HADS)—two days before the surgery and visual analogue scales (VAS) for pain and stress, two days before the surgery and again about two days after. In addition, after their surgery, they took part in a structured interview about what helped them prepare for and cope with the surgery. Most patients tolerated the awake surgery well, scoring low on stress and pain scales. They reported a lower level of stress during the surgery (when questioned afterwards) than before it. Intensity of stress before the surgery correlated negatively with age, positively with HADS anxiety score and positively with stress subsequently experienced during surgery. The level of stress during surgery was associated with stress experienced before the surgery, pain and HADS anxiety and depression scores. Severity of pain during the surgery was positively correlated with stress during surgery and HADS depression and anxiety scores before the surgery. There was no correlation between stress, pain, anxiety and depression and the location of the lesion. Patients have a high tolerance for awake craniotomy. Various factors have an impact on how well patients cope with the operation. Extensive preoperative preparation should be considered a key part of the procedure.