bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging the Ability of the Online Health Information Seekers to Find Credible Online Sources
Authors: Hassan Radwa Ibrahim Ali , Sabry Hend Aly 
Published: March 2023

Abstract

Background: The spread of misinformation about different health issues, has become a growing threat nowadays. The process of identifying credible information became a real problem of high urgency. It took a new dimension with the creation of numerous web platforms and the ubiquity of internet coverage.
During the current pandemic of COVID-19, misinformation is not the only challenge, the infodemic is another serious consequence of growing digitization. Infodemic is defined as an excessive amount of information about a problem that is typically unreliable, false, or misleading, spreads rapidly, and makes a solution more difficult to achieve. This causes anxiety and mistrust in health authorities, leading to decrease capacities for decision-making and undermining public responses, especially during disease outbreaks or pandemics.
Aim: The current study was designed to evaluate the effect of implementing a digital intervention training module, to educate participants about choosing credible online health information, according to the quality standards and protocols.
Methods: This is a quasi-experimental study with pre/post-assessment comparisons. It took place between October 2019 and May 2020 with the recruitment of a group of 480 medical students, from the 1st, the 2nd, and the 3rd academic years, at the Faculty of Medicine. They were assigned to an intervention and a control group. The intervention group attended the digital health module, which was conducted online with both its theoretical and practical components. Participants responded to the pre- and post-online questionnaire through google forms, in addition to a post-intervention assessment.
Results: Results showed post-assessment significant improvements in all items related to seeking online health information and the ability to check the credibility of such information, among the intervention group in comparison to the control group with p-value< 0.05.
Conclusion: The infodemic caused by COVID- 19 pandemic, with all its associated psychological pressure and panic due to misinformation, made it crucial to disseminate awareness about credible digital information sources. Targeted digital health interventions regarding online health information quality and credibility, are highly promising, due to the safe outreach and accessibility without any physical contact, especially during the pandemic time.
Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills
Authors: Roumier Anne , Albertini Giulia , D'Andrea Ivana , Druart Mélanie , Béchade Catherine , Nieves_Riveira Nayadoleni , Etienne Fanny , Magueresse Corentin Le , Rebsam Alexandra , Heck Nicolas , Maroteaux Luc 
Published: March 2023

Abstract
The proper maturation of emotional and sensory circuits requires a fine tuning of serotonin (5-HT) level during early postnatal development. Consistently, dysfunctions of the serotonergic system have been associated with neurodevelopmental psychiatric diseases, including autism spectrum disorders (ASD). However, the mechanisms underlying the developmental effects of 5-HT remain partially unknown, one obstacle being the action of 5-HT on different cell types.
Here, we focused on microglia, which play a role in brain wiring refinement, and we investigated whether the control of these cells by 5-HT is relevant for neurodevelopment and spontaneous behaviors. Since the main 5-HT sensor in microglia is the 5-HT2B receptor subtype, we prevented 5-HT signaling specifically in microglia by conditionally invalidating Htr2b gene in these cells. We observed that abrogating the serotonergic control of microglia during postnatal development impacts the phagolysosomal compartment of these cells and their proximity to dendritic spines, and perturbs neuronal circuits maturation. Furthermore, this early ablation of microglial 5-HT2B receptors leads to adult hyperactivity in a novel environment and behavioral defects in sociability and flexibility. Importantly, we show that these behavioral alterations result from a developmental effect, since they are not observed when microglial Htr2b invalidation is induced later, at P30 onward.
Thus, a primary alteration of 5-HT sensing in microglia, during a critical time window between birth and P30, is sufficient to impair social and flexibility skills. This link between 5-HT and microglia may explain the association between serotonergic dysfunctions and behavioral traits like impaired sociability and inadaptability to novelty, which are prominent in psychiatric disorders such as ASD.
Integration of Fractal Geometry and Correspondence Analysis Reconnaissance for Geochemically High-Potential Promising Areas NE Iran
Authors: Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Kianoush Pooria , Ebrahimabadi Arash , Shirinabadi Reza 
Published: March 2023

Abstract
In geochemical exploration, in order to highlight the local anomalies, the background Anomaly separation is required. Most geochemical and geostatistical analysis in mining exploration requires removing regional trends in order to obtain local anomalies. In this paper, Khusf stream sediment was studied based on fractal geometry and correspondence analysis methods. This paper conducted a chemical analysis of fluvial sediments to find high-potential areas of Pb, Cd, and As elements in the Khusf area of South Iran's Khorasan province using fractal anomaly separation technique. Correspondence analysis with 170 samples through 20 elements concentration values in each sample was performed. According to correspondence analysis, among one or several elements in the study area was separated which the highest concentration relative to the variables Pb, As, and Cd elements. The correspondence analysis revealed that in the Khusf area at some locations Pb, Cd, and as elements have been accumulated anomalously. After the correspondence analysis, the best variogram for the Khusf area was obtained. Elemental concentration maps was then produced through estimating the values using kriging method. Therefore using the fractal method, between three statistical sets of elements, it was concluded that the third set showed the anomaly for Pb, Cd, and As elements. Local anomaly values are respectively determined as 55, 7.2, and 0.88 ppm. Finally, it is suggested that this region has the possibility of Basic Metals occurrence and suggests further geophysical operations on a local identification scale.
Alternative reimbursement models for health providers in high performance sport: stakeholder experiences and perceptions
Authors: Carter Hannah Elizabeth , Allen Michelle , Toohey Liam A. , McPhail Steven M. , Drew Michael K. 
Published: March 2023

Abstract
Background
Value-based healthcare provider reimbursement models have been proposed as an alternative to traditional fee-for-service arrangements that can align financial reimbursement more closely to the outcomes of value to patients and society. This study aimed to investigate stakeholder perceptions and experiences of different reimbursement systems for healthcare providers in high performance sport, with a focus on fee-for-service versus salaried provider models.
Results
Three in-depth semi-structured focus group discussions and one individual interview were conducted with key stakeholders across the Australian high performance sport system. Participants included healthcare providers, health managers, sports managers and executive personnel. An interview guide was developed using the Exploration, Preparation, Implementation, Sustainment (EPIS) framework, with key themes deductively mapped to the innovation, inner context and outer context domains. A total of 16 stakeholders participated in a focus group discussion or interview. Participants identified several key advantages of salaried provider models over fee-for-service arrangements, including: the potential for more proactive and preventive models of care; enhanced inter-disciplinary collaboration; and the ability for providers to have a deeper understanding of context and how their role aligns with a broader set of priorities for an athlete and the organisation. Noted challenges of salaried provider models included the potential for providers to revert to reactive care delivery when not afforded adequate capacity to provide services, and difficulties for providers in demonstrating and quantifying the value of their work.
Conclusions
Our findings suggest that high performance sporting organisations seeking to improve primary prevention and multidisciplinary care should consider salaried provider arrangements. Further research to confirm these findings using prospective, experimental study designs remains a priority.
Mental health during COVID-19: an evaluation of an academic university’s contribution to existing research
Authors: Tawil Samah , Salameh Pascale 
Published: March 2023

Abstract
Background:Increases in mental health problems have been observed during COVID-19 pandemic. Therefore, this topic of research became a priority, especially at the academic level. The objectives of this review were to summarize an institutional contribution to mental health research during the era of COVID-19.
Methods: A scoping review of studies conducted at a local university and examining alterations in mental health during the pandemic during the last three years was conducted.
Results: Fifty-five studies were included. These focused on different mental health changes that occurred in the era of COVID-19 such as changes in work habits or existing psychological conditions, COVID-19-related fear depression, anxiety and stress. Most of the included studies were observational (76.7%). The majority of the publications were published in Scimago Journal Rank Q1 journals (57.1%). The average number of citations per publication was 15.3±30.13 [0-125]. The number of citations was higher in papers with international collaboration of authors (p=0.031). Publications with COVID-19 as a main objective were more cited than papers not directly related to this subject (25.9±39.45 vs. 4.14±3.2; p=0.044).
Conclusion: Mental health problems are a common response to the COVID-19 pandemic. The contribution of a local university to different mental health research studies that took place during COVID-19 outbreak have underlined this reality. However, more representative research from other institutional settings will be needed, particularly in vulnerable populations.
Network analysis using cytoscape
Authors: Verma Srishti , Mangla Lakshay 
Published: March 2023

Abstract

In the following research, we have made cytoscape an easy and compact tool for network analysis. We study the relation between the data sets. Creating edge list and node list for determining relations between the columns and rows hence forming a csv table for the same. Here we have used Cytoscape and Open refine software. Open refine to create the csv file and cytoscape to study the networks.
The Role of Basement Faults in the Miocene Formations of Fars and Bandar Abbas Hinterland, Southern Iran
Authors: Moshkelgosha Maryam 
Published: March 2023

Abstract
The Zagros fold and Thrust Belt (ZFB) is located in southwestern Iran. The geological structure of this region consists of a set of northwest–southeast trending compact anticlines and synclines with upright axial planes. This indicates that (ZFB) the marginal and mobile section of the Arabian platform. In the last stages of sedimentation in this vast basin, the folds are inclined to the southwest due to progressive change in the fold axial planes. For the first time, the tectono- stratigraphy of the Miocen Formations of Fars and Bandar Abbas Hinterland, Southern Iran has been studied in this article. For this purpose, the stratigraphic section of Miosen Formationin five different location namely, Bastak, Taghdis-e- Bahar, Dasht-eArzhan, Saedi mountain, and Yasuj have been collected and analyzed. To the Isopach map prepared for the region, the thicknesses of the Miocene Formations vary in all of these locations. In the Arjan plain the sedimentary facies of the evaporitic sedimentary rocks of Gachsaran Formation changes to the marine sedimentary rocks of the Rzak Formation and the calcareous rocks of Asmari Formation along a northwest – southwest border. This facies change could be related to the activity of basement fault zone such as, Kareh – Bas, Sabzpooshan, Sarvestan, and Kazerun. Tectonic- stratigraphic studies in this paper indicate that changes in sedimentary basin depth and facies changes of the sedimentary rock were affected by several basement faults that followed the Arabian trend. while others basement faults controlling the sedimentary basin in the region in Miocene are in line with the Zagros trend.
Frequency of serological results of antibodies related to autoimmune hepatitis in patients with non-viral hepatitis referring to an inpatient clinic in 2019
Authors: Basir Hamid Reza Ghasemi , Khalilian Alireza , Eslami-Ghayour Anahita , Ghobakhlou Mehdi 
Published: March 2023

Abstract
Background
Autoimmune hepatitis as a chronic inflammatory disease of the liver can occur when the body's immune system is stimulated against liver cells, but its exact cause is unknown. Autoimmune hepatitis, if left untreated, leads to liver damage or cirrhosis over time, which can eventually cause liver failure.
Objective
This descriptive-analytical study was done to assess the frequency of serological results of autoimmune hepatitis-related antibodies in patients with non-viral hepatitis referring to an inpatient clinic in 2019 and provide basic information for future studies and assistance in localization of external guidelines performed to diagnose autoimmune hepatitis.
Methods
All patients were evaluated for age and sex, ANA, ASMA, and LKM antibodies, and immunoglobulin by preparing 5 cc of blood samples using laboratory techniques and electrophoresis. The collected data were recorded in the checklist created by the researcher.
Results
The total number of 209 patients with non-viral hepatitis, with a mean age of 37.98 years participated in this study. In patients with non-viral hepatitis, 50.2% of patients had polyclonal hypergammaglobulinemia, in 17.2% ANA was positive, in 16.3% ASMA was positive, and 1.9% LKM was positive.
Conclusion
hypergammaglobulinemia, ANA, and ASMA are suitable antibodies for autoimmune hepatitis. Moreover, laboratory results of ANA and ASMA in patients with autoimmune hepatitis indicate low levels of these antibodies in Iran and their deficiency in other countries. Conventional diagnostic methods can provide a definitive diagnosis. Therefore, it shows the need for further examination of laboratory instruments and wider use of other diagnostic methods, including biopsy and further assessments.
Comparison of Infliximab with Adalimumab for the treatment of non- infectious uveitis: a systematic review and meta-analysis
Authors: Liu Weishai , Bai Dan , Kou Lieling 
Published: March 2023

Abstract
Purpose: To compare Infliximab and Adalimumab on the efficacy and safety for the treatment of non-infectious uveitis (NIU).
Methods: We searched for relevant studies in the PubMed, Embase, ClinicalTrials.gov, Cochrane Library databases, with language restricted in English, China National Knowledge Infrastructure (CNKI), and Wan Fang databases up to September 2022. The incidences of complete inflammation remission, overall inflammation remission, adverse events and corticosteroid-sparing effects were evaluated.
Results: Eleven clinical trials covering 1459 NIU patients were included. Complete inflammation remission after therapy was achieved in 161 (37.5%) patients in Infliximab group and 151 (39.6%) patients in Adalimumab group. These two groups had no significant difference (P = 0.37). Overall inflammation remission of anti-TNF drugs involved 449 patients, with 241/272 (88.6%) being treated with Infliximab and 153/177 (86.4%) being treated with Adalimumab. No signiﬁcant difference was observed with regard to the overall inflammation remission between the two cohorts (P = 0.86). There were no significant differences between Infliximab and Adalimumab as far as corticosteroid-sparing effects (P = 0.58). Pooled effect size (P = 0.001) showed a statistically significant difference, with incidence of adverse events being 17.91% in Infliximab and 12.12% in Adalimumab.
Conclusion: Our systematic review and meta-analysis of 11 studies suggests that Infliximab and Adalimumab offer similar therapeutic efficacy and corticosteroid-sparing effects for patients with NIU. But Adalimumab has a marginal advantage over Infliximab in terms of adverse events. Large-scale RCTs with a longer follow-up are required to further evaluate these two anti-TNF-α agents for NIU patients.
Lymphoproliferative disorder during temozolomide therapy; a representative case of a formidable complication and management challenges
Authors: Sato Daisuke , Takami Hirokazu , Shunsaku Takayanagi , Taoka Kazuki , Tanaka Mariko , Matsuura Reiko , Tanaka Shota , Saito Nobuhito 
Published: March 2023

Abstract
Background: Lymphoproliferative disorder represents a heterogeneous clinicopathological spectrum characterized by uncontrolled proliferation of lymphocytes. Immunodeficiency is a major trigger of its development. While induction of immunodeficiency is a well-known adverse effect of temozolomide therapy, development of lymphoproliferative disorder following temozolomide therapy has not previously been described.
Case presentation: A patient with brainstem glioma developed constitutional symptoms, pancytopenia, splenomegaly and generalized lymphadenopathy during the 2nd cycle of maintenance therapy following induction therapy with temozolomide. Epstein-Barr virus-infected lymphocytes were observed histopathologically and “other iatrogenic immunodeficiency-associated lymphoproliferative disorder” (OIIA-LPD) was diagnosed. Although discontinuation of temozolomide led to rapid remission, relapse was observed 4 months later. CHOP chemotherapy was induced, resulting in secondary remission. Vigilant follow-up for another 14 months showed radiologically stable brainstem glioma and no further recurrence of OIIA-LPD.
Conclusions: This is the first report documenting OIIA-LPD during temozolomide administration. Timely diagnosis of the disease and discontinuation of the causative agent were considered to be the management of choice. Close monitoring for relapse should be continued. Finding a balance between glioma management and controlling the remission of OIIA-LPD remains to be clarified.
Inflammatory memory restrains intestinal stem cell regeneration
Authors: Reddy Pavan , Zhao Dongchang , Ravikumar Visweswaran , Lauder Emma , Li Lu , Sun Yaping , Oravecz-Wilson Katherine , Brooks Michael , Keller Evan , Chen Fengju , Maneix Laure , Santibanez Ana , Creighton Chad , Rao Arvind 
Published: March 2023

Abstract
Intestinal stem cells (ISC) encounter inflammatory insults in immune mediated gastro-intestinal (GI) diseases. It remains unknown whether, and how, they adapt, and if the adaptation leaves scars on the ISCs that affects their subsequent regeneration capacity. We investigated the consequences of inflammation on Lgr5+ISCs in well-defined clinically relevant models of gastro-intestinal acute graft-versus-host disease (GI GVHD). Utilizing single cell transcriptomics, organoid, metabolic, epigenomic and in vivo models we found that Lgr5+ISCs undergo metabolic changes that lead to accumulation of succinate, which reprograms its epigenome. These changes reduced the ability of ISCs to differentiate and regenerate ex vivo in serial organoid cultures demonstrating the persistence of the maladaptive impact of an in vivo inflammatory encounter by the ISCs. Thus, inflammation from GI GVHD leaves a memory of its effects on ISCs that persist and are likely to affect their sensitivity to adapt to future stress or challenges.
Parametric Resonance Climate Model
Authors: Caccamo Maria Teresa , Magazù Salvatore 
Published: March 2023

Abstract
The variations in the distribution of solar radiation due to the ∼105 years Milankovitch cycle alone cannot explain the sharp drop in temperature of approximately 10 K that marks the transition from the interglacial to the glacial age registered in the last ∼5.5 106 years temperature variation behavior. More specifically, only a temperature variation of 0.2÷0.3 K can be attributed to this ∼105 years cycle connected to the Earth eccentricity variation and, therefore, positive feedback effects should be taken into account to explain the registered effect. In the present work, a parametric resonance model for climate that justifies the temperature variation from the interglacial to the glacial age is postulated. According to this model, the system energization is due to periodic variations in the internal solar system parameters. In particular, it is put into evidence that the model works when only a weak oscillation is present in the system and that even small oscillations increase over time proportionally to the system energy itself, i.e., exponentially, and hence, a series of connected resonances is able to energize the system.
Aftershocks following the 2011 Tohoku-Oki earthquake driven by both stress transfer and afterslip
Authors: Ueda Taku , Kato Aitaro 
Published: March 2023

Abstract
Aftershocks are a fundamental characteristic of seismicity, and their generation mechanism is mainly characterized by two physical models, stress transfer from large earthquakes and afterslip-induced stress loading. However, the contribution of each mechanism to aftershock generation remains unclear. Here we investigate the spatiotemporal variations in aftershock activity following the 2011 Tohoku-Oki earthquake by applying the Hierarchical Space-Time Epidemic-Type Aftershock Sequence (HIST-ETAS) model to the decade of recorded seismicity since the mainshock. Using the estimated HIST-ETAS model, we categorize the aftershocks into background earthquakes (which are caused by aseismic phenomena) and triggered earthquakes (which are caused by earthquake-to-earthquake interactions). Most of the earthquakes that occurred updip of the large coseismic slip zone along the Japan Trench are triggered earthquakes, consistent with the lack of afterslip in this area. Conversely, background earthquakes are the predominant earthquake type in the long-term downdip of the large coseismic slip zone, and they positively correlate with the afterslip evolution. Our results suggest the importance of combining these two end-member aftershock generation models to explain aftershock activity and thus provide new insights into the relationship between afterslip and spatiotemporal aftershock distribution. Our classifications may also contribute to the monitoring of afterslip in a given region that hosts a large earthquake, particularly where geodetic observation networks are too sparse to evaluate afterslip evolution.