bluuebunny/crossref_metadata_2025_split huggingface dataset:
New materials for the manufacture of intracanal pins
Authors: Krikheli N. I. , Pustovoit E. V. , Nozdrina M. S. , Rudneva O. V. , Peretyagin P. Yu. , Khodanovich N. V. , Naumenko P. A. , Zhukovskaya Yu. I. 
Published: January 2025

The issue of tooth strength loss due to hard tissue loss after endodontic treatment remains relevant. Intracanal pins and cores are widely used for long-term restoration of the anatomical and functional integrity of depulped teeth. Modern studies focus on the multifactorial nature of morphofunctional processes of restoration of lost tissues. The main parameters are the size of the restored crown, the shape of the root canal and the redistribution of occlusal loads. Physicochemical characteristics of pin materials are also important, such as: biocompatibility, strength, elasticity, hypoallergenicity, adhesion quality and aesthetics. Previously, preference was given to metal pins, but they have disadvantages: corrosion, weak connection and low aesthetics, which makes them less attractive compared to modern alternatives. In connection with the above, the purpose of this study is to develop a technology for the two-stage manufacture of graphene-containing dental pins using the 3D printing method. Materials and methods: The technology for manufacturing dental pins is based on the use of the method of printing monoceramic dental products. The process uses a zirconium suspension, which is a poorly soluble viscous white liquid with a specific odor, with which printing will occur. As part of the development of the technology for producing monoceramic dental products, a large number of dental pins were printed using an additive printer based on selective laser stereolithography. Then, the porous blanks will be pre-functionalized with a suspension of graphene oxide and sintered in vacuum conditions, and will be studied further. Thus, the introduction of 3D printing technology in the process of manufacturing dental pins will open up opportunities for the use of new promising domestic materials in clinical practice.
Investigation of the general state of oral hygiene in patients undergoing orthodontic treatment
Authors: Razumova S. N. , Brago A. S. , Nemer A. S.M. , Artemova O. A. , Razumov N. M. , Temejza S. S.M. 
Published: January 2025

Relevance. In patients with orthodontic structures, plaque accumulating for a long time around a non-removable device can lead to enamel demineralization, rapidly progressing to a carious cavity and the development of gingival inflammation. An important aspect of the management of such patients is measures to reduce the risk of caries and improve the effectiveness of oral hygiene. The aim of the study was to assess the level of oral hygiene in patients undergoing orthodontic treatment in groups with different methods of enamel preparation before fixing braces. Materials and methods. A randomized, controlled trial was conducted involving 60 patients aged 18–30 years. To assess the level of oral hygiene and the intensity of caries, we determined: the DMF index, the index of oral hygiene of OHI-S. The assessment of the enamel condition after removal of braces was carried out using the Adhesive Remnant Index (ARI). Universal Bond adhesive system (Tokuyama Dental), SHIELD FORCE PLUS varnish (Tokuyama Dental), double-curing adhesive fixing cement ESTECEM PLUS (Tokuyama Dental) were used to fix the braces. The effectiveness of oral hygiene was evaluated before treatment and 12 months after the start of orthodontic treatment. Results. There was a statistically significant decrease in the index of ОНІ-S in patients with ceramic and metal braces, the enamel surface of which was treated with varnish. The index of ОНІ-S before the start of the study in patients with ceramic braces was 1.5 ± 0.12, with metal ones – 1.4 ± 0.47. After 12 months, the index values were 1.6 ± 0.36 and 1.5 ± 0.46, respectively, p = 0.002. In the group of patients whose surface was not treated with varnish, the index values were statistically not significant, p > 0.05. When assessing the resistance of teeth to the development of caries using the DMF index, a statistically significant difference was also found in groups where bracket systems were fixed with pretreatment of the enamel surface with varnish. The value of the DMF index before the start of the study in the group of patients with ceramic braces was 1.7 ± 0.22, in the group with metal braces – 1.4 ± 0.14. After 12 months, the index values were 1.8±0.16 and 1.5 ± 0.23, respectively, p = 0.0012. Conclusion. The use of varnish before fixing braces helps to improve the condition of the oral cavity, which is expressed in improved hygiene, as well as in the absence of pathological changes on the enamel surface in the form of demineralization. In this regard, further studies are needed to assess the degree of influence of varnishes on the condition of the oral cavity in patients undergoing orthodontic treatment.
Study of the efficacy of antibacterial tongue foam with cetylpyridinium chloride
Authors: Bessonova E. A. , Kozlov M. E. 
Published: January 2025

Relevance. The amount of data on the relationship between the oral microbiome, in particular the tongue, and systemic health is constantly growing, while the impact of various antibacterial agents on this ecosystem remains insufficient. Study objective: to evaluate the effectiveness of an antibacterial tongue foam containing cetylpyridinium chloride. Materials and methods. The study included 30 patients who were randomized into 3 groups comparable in terms of the initial tongue hygiene index. Group 1 used only a toothbrush and toothpaste without antiseptics for home care, group 2 additionally used a scraper, group 3 – a brush, hygienic paste, scraper and antibacterial foam. All three groups were compared based on the results of assessing the Ulitovsky tongue hygiene index at baseline and 14 days after the appointment of hygiene products. In groups 2 and 3, an additional microbiological study was conducted. Results. The study of the results of the index assessment of the hygienic condition of the tongue showed that statistically significant differences were obtained between the beginning of the study and its end in groups 2 and 3, while in group 3 the changes were more pronounced. And when comparing all three groups, reliable differences were obtained between the study groups. The microbiological study of groups 2 and 3 yielded statistically significant differences in the performance of the antibacterial foam in relation to the Enterobacteriaceae family, the Streptococcus family, the Gardnerella vaginalis + Prevotella bivia + microorganism group of the Porphyromonas family, the Peptostreptococcus family, the Candida family, namely, a decrease in their number, according to the quartile analysis. Conclusions. The use of antibacterial foam containing cetylpyridinium chloride in combination with the use of a tongue scraper significantly improves the hygienic condition of the tongue and the composition of the microflora.
Features of clinical, radiological and differential diagnosis of productive-destructive form of chronic osteomyelitis
Authors: Trofimov S. A. , Drobyshev A. Y. , Shulakov V. V. , Lezhnev D. A. , Laschuk S. Y. 
Published: January 2025

Primary chronic osteomyelitis of the jaw bones is a rare and poorly studied pathology in the maxilofacial region, which causes difficulties in diagnosis, differential diagnosis and treatment. In this regard, the purpose of this study was to identify significant diagnostic and differential diagnostic clinical and radiological criteria in patients with productive-destructive form of chronic osteomyelitis of the jaw bones. 53 patients with chronic forms of osteomyelitis of the jaw bones were examined and treated. The main criteria that are important in the diagnosis of productive-destructive form of chronic osteomyelitis and comes as basis for planning comprehensive treatment were identified.
Assessment of the state of mineral metabolism in patients with tooth loss during dental implantation against the background of vitamin D deficiency
Authors: Diachkova E. Yu. , Skachkova M. M. , Tarasenko S. V. , Zharova K. Yu. , Kytko E. N. 
Published: January 2025

Background. The widespread occurrence of mineral metabolism disorders in the modern world, including those due to vitamin D deficiency, affects the results of patient rehabilitation performed by dental surgeons using dental implants. The aim of the study was to assess the state of mineral metabolism during dental implantation in young and middle-aged patients with tooth loss due to vitamin D deficiency. Materials and methods. From 2011 to 2024, 450 patients aged 25–50 years with tooth loss due to identified vitamin D deficiency in the absence of other somatic pathology were examined and treated at Sechenov University and a private clinic. All patients underwent laboratory examination, including assessment of mineral metabolism indicators – the level of total calcium, vitamin D (25 (OH) D), parathyroid hormone, thyroid stimulating hormone. Also, 30 randomly selected patients underwent assessment of osteogenesis markers (bone matrix formation marker P1NP, serum cross-linked C-telopeptide of type I collagen CTX). Patients were referred to an endocrinologist due to detected vitamin D deficiency, therapy was prescribed. All patients underwent dental implantation and concomitant surgeries to increase bone volume, if necessary, considering the study group: in group 1 – until reference values of vitamin D were achieved, in group 2 – after. Comparison of parameters before and after drug therapy was performed using Student’s T-test or Mann-Whitney, the results were considered statistically significant at p < 0.05. Results. In the examined sample, 2.1 % of patients had a pronounced deficiency of (25(OH)D) (< 10 ng/ml), 60.4 % had a deficiency (< 20 ng/ml), and 37.5 % had insufficiency (20–30 ng/ml), with the initial level of vitamin D in both study groups not statistically different (< 20 ng/ml, p < 0.05). After the treatment, the level of (25(OH)D) in all patients reached the reference values (30–60 ng/ml, p < 0.05) also without statistically significant difference when compared by groups (median 1 = 42.75 and median 2 = 43.65, respectively, p > 0.05), but was significantly higher when assessed dynamically within eachgroup (p < 0.05). No deviations from reference values for osteogenesis markers were found over time, although a statistically significant slight decrease in both parameters within the normal range was noted after treatment compared to the initial level (p < 0.05). Conclusion. In young and middle-aged patients with tooth loss due to vitamin D deficiency, no significant changes in laboratory parameters (blood calcium levels, parathyroid hormone, and osteogenesis markers over time) were found during dental implantation and concomitant surgeries.
Priority areas for the formation of specialized care for children with congenital cleft of the maxillofacial region, complicated by anomalies of other organs and systems
Authors: Rogozhina Yu. S. , Blokhina S. I. , Bimbas E. S. 
Published: January 2025

Topicality. The specialized literature does not sufficiently present the systematization of concomitant malformations additional to congenital cleft of the maxillofacial region, the frequency of their occurrence and the species correlativity of relationships. There is no program for concretizing the interaction of specialists in different fields that ensure the unity of the processes of diagnosis and rehabilitation of patients with complex disorders of embryogenesis. Purpose. To present the main directions of specialized care for children with congenital cleft of the maxillofacial region in combination with malformations of other organs and systems. Materials and methods. A group of patients (823 people) who received treatment at the Center «Bonum» (Yekaterinburg) for a period of 25 years (1998–2022) with cleft maxillofacial region and concomitant malformations was studied. In the course of the study, the data of malformations were systematized, and correlations between congenital concomitant defects were identified. Clinical and special methods of patient examination were used in the study. Results. An innovative methodology for systematic monitoring and treatment of patients with maxillofacial cleft in combination with concomitant malformations has been developed based on a staged algorithm of therapeutic and corrective interactions of rehabilitation specialists of various profiles. The optimal tactics of the interacting advantages of the treatment process of concomitant congenital malformations are presented, taking into account the sequence of rehabilitation measures, the volume and duration of surgical elimination of the cleft against the background of concomitantanomalies. Conclusions. The proposed methodological algorithm for the dynamic observation of 823 patients with cleft of the maxillofacial region, complicated by malformations of other organs and systems, has absorbed the fundamental directions of therapeutic and corrective interactions of specialists in various fields, concentrating knowledge and experience on this issue for a period of 25 years (1998–2022) and made it possible to minimize postoperative complications (the indicator of residual deformities of the upper lip and nose after the primary cheilorhinoplasty amounted to 16,16 %, and after velourinoplasty – 2,46 %), to successfully complete (in 73,63 % of cases) the main stages of surgical treatment of the maxillofacial region, as well as the main processes of restoring the health of this group of patients in accordance with the age periods of rehabilitation.
The role of biotribocorrosion in the development and progression of clinical manifestations of pseudomembranous candidiasis
Authors: Tsalikova N. A. , Mamedova G. F. , Ashrapova L. R. 
Published: January 2025

Objective. To establish the effect of biotribocorrosion on the development and chronic course of pseudomembranous candidiasis. Materials and methods. The study was conducted at the Department of Orthopedic Dentistry and Gnatology and at the Department of Propaedeutics of Orthopedic Dentistry of the Russian University of Medicine. The study involved 80 patients with pseudomembranous candidiasis using metal dentures and 40 patients with pseudomembranous candidiasis without metal-containing structures, who made up the control group. All participants in the study measured the difference in oral biopotentials, hydrogen index, and salivation rate. Results. In patients of the main group, the content of Fe, Cr, Ni, Ti, Si, K, Na in saliva was significantly increased (p < 0.05) compared with the control group. It was found that dissimilar metal alloys have different effects on the duration of use of dentures. In pseudomembranous candidiasis and the presence of metal-containing structures with signs of biotribocorrosion, a more pronounced electrochemical reaction of stainless steel coated with titanium nitride and uncoated significantly reduces the life of dentures (from 3 to 5 years), compared with CCC metal-ceramic prostheses (from 2 to 10 years) and Ni-Cr-Ni-Cr (from 5 to 8 years old). The greatest pH shift to the acidic side is observed with a combination of stainless steel and Ni-Cr prostheses (pH 5.5–6.0). In pseudomembranous candidiasis, patients using metal dentures have the highest potential differences between M-M. Conclusions. Due to tribocorrosion, corrosion products enter the oral fluid, under their influence, a decrease in pH occurs, provoking a weakening of the protective properties of saliva, a violation of metabolic processes and structural changes in the oral mucosa. Thus, there is a favorable environment for the growth of fungi of the genus Candida, inflammation of the oral mucosa occurs. Microbial flora and fungi that stimulate the development of the inflammatory process are localized in inflammatory areas.
Comparison of transparency indicators of domestic samples of dental multilayer ceramics based on zirconium dioxide with indicators of a foreign analogue under different sintering modes
Authors: Nenasheva E. A. , Bykova M. V. , Guk N. O. , Nazaryan R. G. , Lebedenko I. Y. 
Published: January 2025

Relevance. New dental materials made of zirconium dioxide include 3Y-TSP and 5Y-TSP, suitable for various clinical cases, including multilayer systems that create a transparency gradient. After milling, the pre-sintered Y-TZP frames must be subjected to final sintering in 8–10 hours, although modern technologies can reduce it to 17 minutes. However, high-speed sintering can degrade the color and transparency of finished prostheses. The new monolithic ceramic systems have increased the Y3+ content to about 4 and 5 ml. %, but the indicators of layered transparency of multilayer samples after high-speed sintering remain insufficiently studied. The purpose of the work. The study of layered transparency after traditional and high-speed sintering of domestic multilayer ceramics made of zirconium dioxide and its imported analog using a laboratoryspectrophotometer. Materials and methods. Groups of 12 samples were studied: the main one (domestic production of «Ziceram ML ET») and the control one (Chinese production of «Aidite 3D Pro»), divided into subgroups «a» (traditional sintering) and «b» (high-speed sintering). The size of all samples is 15×15×1 mm, colors A1–A3, milled by removing plates from a single layer. Subgroups «a» were fired according to traditional modes with an exposure time of 30–120 minutes. Subgroup «b» was baked in a high-speed furnace in 25 minutes. Transparency was assessed using an X-Rite Ci4200 spectrophotometer using the CIE Lab* system, calculating the ratio of the «L» luminance indicators on a white and black background. Conclusions. The lightness of the layers of multilayer ceramic blanks «Ziceram ML ET» and «Aidite 3D Pro» is significantly reduced after high-speed sintering compared to traditional firing. The transparency gradients of Russian and Chinese multilayer ceramics differ, with significant changes after high-speed sintering.
Kinematic and muscle co-activation patterns in the dominant arm across forehand stroke phases in wheelchair tennis
Authors: Abuwarda Khaled , Akl Abdel-Rahman 
Published: January 2025

ObjectiveThis study investigated upper limb kinematics and muscle co-activation in wheelchair tennis players during the forehand stroke. By analyzing linear and angular kinematic variables alongside muscle co-activation patterns, the study aimed to provide insights into the biomechanical mechanisms supporting forehand stroke performance.MethodFifteen professional male wheelchair tennis players (height: 163.9 ± 2.05 cm; mass: 64.1 ± 3.07 kg; age: 32.2 ± 7.97 years) participated in this study. Electromyographic data from six muscles around the dominant arm joints were recorded using the Myon system. Four fixed GoPro Hero 8 cameras (120 Hz) captured 3D video, and kinematic analyses were performed using the APAS system. The forehand stroke was analyzed across three phases: (1) backswing, (2) forwardswing, and (3) follow-through.ResultsThe results showed significant phase-specific changes in muscle co-activation for the shoulder (p &lt; 0.001), elbow (p &lt; 0.005), and wrist (p &lt; 0.01). Muscle co-activation was highest during the backswing phase, decreased during the forwardswing, and increased again during the follow-through phase. This pattern reflects the need for joint stability and control, particularly when changing stroke direction and slowing the arm after impact.ConclusionThese findings provide novel insights into the kinematic and neuromuscular mechanisms underlying the forehand stroke in wheelchair tennis. The data provide hypotheses about potential training and rehabilitation strategies that should be tested by prospective studies. The results also highlight the unique demands of wheelchair tennis, contributing to inclusive, evidence-based approaches to enhancing performance and safety in disability sports.
Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease
Authors: Zhang Yi , Ou Guangyang , Peng Lei , Pan Jian , Zhang Shaohua , Shi Jianguo 
Published: January 2025

ObjectiveThe impact of lipid-lowering medications on chronic kidney disease (CKD) remains a subject of debate. This Mendelian randomization (MR) study aims to elucidate the potential effects of lipid-lowering drug targets on CKD development.MethodsWe extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summary statistics, encompassing LDLR, HMGCR, PCSK9, NPC1L1, APOB, ABCG5/ABCG8, LPL, APOC3, ANGPTL3, and PPARA. A Mendelian randomization analysis was conducted targeting these drug-related genes. CKD risk was designated as the primary outcome, while estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN) were assessed as secondary outcomes. Additionally, mediation analysis was performed utilizing 731 immune cell phenotypes to identify potential mediators.ResultsThe meta-analysis revealed a significant association between ANGPTL3 inhibitors and a reduced risk of CKD (OR [95% CI] = 0.85 [0.75-0.96]). Conversely, LDLR agonists were significantly linked to an increased risk of CKD (OR [95% CI] = 1.11 [1.02-1.22]). Regarding secondary outcomes, lipid-lowering drugs did not significantly affect eGFR and BUN levels. Mediation analysis indicated that the reduction in CKD risk by ANGPTL3 inhibitors was mediated through modulation of the immune cell phenotype, specifically HLA-DR on CD14+ CD16+ monocytes (Mediated proportion: 4.69%; Mediated effect: -0.00899).ConclusionThrough drug-targeted MR analysis, we identified a causal relationship between lipid-lowering drug targets and CKD. ANGPTL3 and LDLR may represent promising candidate drug targets for CKD treatment.
Non-high-density to high-density lipoprotein cholesterol ratio and its association with infertility in U.S. women: a cross-sectional study
Authors: Zhang Yajie , Lu Cong , Li Lili , Li Hongyu 
Published: January 2025

ObjectiveTo investigate the relationship between Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) and infertility in US female adults aged 20 to 45.MethodsOur research team utilized data from the 2013–2018 National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional study. Multivariable logistic regression was conducted to examine the association between NHHR and infertility, with trend tests providing additional insight into this relationship. Further, smoothed curve fitting was applied for a more detailed exploration. To ensure the robustness of our results, we conducted subgroup and sensitivity analyses.ResultsBetween 2013 and 2018, our study included 2,947 participants, with 342(11.6%) self-reported infertility. A positive association was found between NHHR and infertility (OR=1.17,95%CI:1.07-1.27). Compared with the first trimester, the third trimester of NHHR was associated with an OR of 1.79(95% CI: 1.31–2.44) in model 3. The results of subgroup analyses revealed that the association between NHHR and infertility was nearly consistent.ConclusionNHHR demonstrated a positive correlation with infertility among U.S. female adults. Further investigation is needed to explore their association better and the underlying mechanisms.