bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sea ferry travel: the tourists’ liminal experience on the ferry
Authors: Sang Senyao , Huang Lingjun 
Published: December 2022

Purpose
This study aims to explore the tourist’s liminal experience on a ferry and form a conceptual framework of liminal experience in the mobile liminal setting from the perspective of island tourists.

Design/methodology/approach
To address the purpose of taking the ferry from Zhoushan Island to Sijiao Island in China as the part of research, a qualitative method research design was used, including participatory observation, in-depth interviews and online data from social media.

Findings
Ferry as a mobile liminal space on the sea provides tourists to experience liminality by perceiving unique time construction, the overlap of physical and figurative space, the sense of liminal community and perceived existential authenticity, embodied spatial practices and perceived liminal benefits and costs under the specific social and cultural contexts.

Practical implications
This study proposes that tourism planners should strengthen tourists’ liminal experience on the ferry through integrated shipscape planning, including ship space planning, theme design and product development, which can make the ferry to be a meaningful place brand.

Originality/value
This study not only confirms that taking tourism public transport such as a ferry is a rite of passage for tourists before entering the island destination but also points out that public transport is a tourist attraction with time, space and social meaning for tourists.
Verticillium dahliae Asp1 regulates the transition from vegetative growth to asexual reproduction by modulating microtubule dynamic organization
Authors: Tian Juan , Pu Mengli , Chen Bin , Wang Guangda , Li Chunli , Zhang Xiaxia , Yu Yanjun , Wang Zhi , Kong Zhaosheng 
Published: December 2022

AbstractVerticillium dahliae is a devastating pathogenic fungus that causes severe vascular wilts in more than 400 dicotyledonous plants. The conidiation of V. dahliae in plant vascular tissues is the key strategy for its adaptation to the nutrient‐poor environment and is required for its pathogenicity. However, it remains unclear about the regulatory mechanism of conidium production of V. dahliae in vascular tissues. Here, we found that VdAsp1, encoding an inositol polyphosphate kinase, is indispensable for the pathogenicity of V. dahliae. Loss of VdAsp1 function does not affect the invasion of the host, but it impairs the colonization and proliferation in vascular tissues. The ΔVdAsp1 mutant shows defective initiation of conidiophore formation and reduced expression of genes associated with the central developmental pathway. By live‐cell imaging, we observed that some of ΔVdAsp1 mutant hyphae are swollen, and microtubule arrangements at the apical region of these hyphae are disorganized. These results indicate that VdAsp1 regulates the transition from vegetative growth to asexual reproduction by modulating microtubule dynamic organization, which is essential for V. dahliae to colonize and proliferate in vascular tissues. These findings provided a potential new direction in the control of vascular wilt pathogen by targeting conidium production in vascular tissues.
Implementing online position monitoring for prostate radiotherapy using an in‐house position monitoring system: User experience and impact on workforce
Authors: Cardoso Michael , Sidhom Mark , Udovitch Mark , Young Tony , Arumugam Sankar 
Published: December 2022

AbstractIntroductionTo evaluate the feasibility of prostate intrafraction motion monitoring using the SeedTracker real‐time image guidance system in order to improve targeting accuracy in prostate radiotherapy.MethodsSeedTracker was used to monitor prostate gold fiducial seeds with kV x‐ray imaging during radiotherapy in 30 patients. Feedback from radiation therapists was collected via the use of a user evaluation form. The impact on treatment time was established by using a record and verify system. The effective dose and a risk of exposure‐induced cancer death (REID) were estimated for a 60‐year‐old patient when using the SeedTracker system.ResultsA total of 22 radiation therapists completed user evaluation forms. The time taken to prepare a reference data set for one patient varied with three (13.6%) radiation therapists taking less than 2 min, 10 (45.5%) between 2 and 4 min, eight (36.4%) between 4 and 6 min and one (4.5%) between 6 and 8 min. The useability of the SeedTracker system was reported as ‘easy’ by 21 (95.5%) radiation therapists and ‘hard’ by 1 (4.5%) radiation therapist. Mean treatment time changed from 6 to 7 min with prostate‐only radiotherapy treatment and from 6.9 to 10.2 min with prostate and whole pelvis radiotherapy treatments. The maximum effective dose with the SeedTracker was 1.6276 mSv, and increase in REID was 0.007%.ConclusionThe SeedTracker real‐time image guidance system is a feasible tool to use in radiotherapy departments to monitor and correct for prostate intrafraction motion.
Patient and public involvement in contemporary large intensive care trials: A meta‐epidemiological study
Authors: Estrup Stine , Barot Emily , Mortensen Camilla Bekker , Anthon Carl Thomas , Crescioli Elena , Kjær Maj‐Brit Nørregaard , Vesterlund Gitte Kingo , Bruun Camilla Rahbek Lysholm , Collet Marie Oxenbøll , Rasmussen Bodil Steen , Sivapalan Praleene , Poulsen Lone Musaeus , Møller Morten Hylander , Perner Anders , Granholm Anders 
Published: December 2022

AbstractBackgroundPatient and public involvement in randomised clinical trials has received increased focus, including in intensive care trials, but the frequency, method and extent is unknown. This meta‐epidemiological study investigated patient and public involvement in contemporary, large ICU trials.MethodsWe systematically searched PubMed for large (≥225 randomised patients), contemporary trials (published between 1 January 2019 and 31 January 2022) assessing interventions in adult patients in ICU settings. Abstracts and full‐text articles were assessed independently and in duplicate. Data were extracted using a pre‐defined, pilot‐tested data extraction form with details on trials, patient and public involvement including categories and numbers of individuals involved, methods of involvement, and trial stage(s) with involvement. Trials authors were contacted as necessary.ResultsWe included 100 trials, with 18 using patient and public involvement; these were larger and conducted in more centres than trials without patient and public involvement. Among trials with patient and public involvement, patients (in 14/18 trials), clinicians (13 trials), and family members (12 trials) were primarily involved, mainly in the development of research design (15 trials) and development of research focus (13 trials) stages and mostly by discussion (12 trials) and solo interviews (10 trials). A median of 65 individuals (range 1–6894) were involved.ConclusionsWe found patient and public involvement in a fifth of large, contemporary ICU trials. Primarily patients, families, and clinicians were included, particularly in the trial planning stages and mostly through interviews and discussions. Increased patient and public involvement in ICU trials is warranted.
Impact of outward foreign direct investment on employment volatility: Evidence from China
Authors: Cen Yuting , Dong Nannan 
Published: December 2022

AbstractDoes outward foreign direct investment (OFDI) help stabilize employment in the home country? This paper studies the relationship between the volatility of employment growth and the OFDI of a firm using matched data of Chinese firms from 2000 to 2019. The empirical analysis shows that employment in OFDI firms is less volatile than that in non‐OFDI firms. For firms in the eastern coastal areas of China, OFDI has a more obvious effect in restraining employment volatility. OFDI is also conducive to reducing employment volatility for firms that conduct OFDI in Asian, European, and American countries. Firms in the service sector conducting OFDI see a greater reduction in employment volatility. In addition, OFDI affects employment volatility mainly through the channels of technological innovation and production transfers. This study recommends that the government enact reforms in the domestic market to encourage more firms in China to invest.
Bringing Indonesia into the global welfare regime debate: A literature review and future research agenda
Authors: Yuda Tauchid Komara , Kühner Stefan 
Published: December 2022

AbstractStudies on welfare state regimes have been dominated by consideration of rich OECD/European and increasingly East Asian countries/territories, leaving South Asian cases such as Indonesia underexplored. The few existing studies that have explicitly tried to conceptualize the Indonesian welfare regime have resulted in little consensus. To address the resulting lack of clarity, this article reviews scholarly articles relevant to bringing Indonesia into the global welfare regime debate, specifically encapsulating how the country has been classified compared with its East Asia counterparts. Accordingly, we find that existing studies have mainly concentrated on the Indonesian health care and social protection expansion, which has led authors to conclude that this evolution demonstrates Indonesia's transition away from welfare productivism. By contrast, we argue that Indonesia's productivist characteristics have largely prevailed while informal networks, clientelism, strong families, and the limited effectiveness of the civil society movement created a specific social politics in Indonesia. We thus conclude that the causal mechanisms typically attributed to welfare development in more developed welfare geographies, including East Asia, cannot fully explain the evident institutional formation in the Indonesian case. The future research agenda for studying the welfare regimes in Indonesia and other Southeast Asian countries is discussed.
CXCR4 antagonists disrupt leukaemia‐meningeal cell adhesion and attenuate chemoresistance
Authors: Jonart Leslie M. , Ostergaard Jason , Brooks Athena , Fitzpatrick Garrett , Chen Liam , Gordon Peter M. 
Published: December 2022

SummaryThe effective prophylaxis and treatment of central nervous system (CNS) involvement in acute lymphoblastic leukaemia (ALL) remains a significant clinical challenge. Developing novel and more effective CNS‐directed therapies has been hampered, in part, by our limited understanding of the leukaemia niche in the CNS relative to the bone marrow. Accordingly, defining the molecular and cellular components critical for the establishment and maintenance of the CNS leukaemia niche may lead to new therapeutic opportunities. In prior work we showed that direct intercellular interactions between leukaemia and meningeal cells enhance leukaemia chemoresistance in the CNS. Herein, we show that the CXCR4/CXCL12 chemokine axis contributes to leukaemia‐meningeal cell adhesion. Importantly, clinically tested CXCR4 antagonists, which are likely to cross the blood–brain and blood‐cerebral spinal fluid barriers and penetrate the CNS, effectively disrupted leukaemia‐meningeal cell adhesion. Moreover, by disrupting these intercellular interactions, CXCR4 antagonists attenuated leukaemia chemoresistance in leukaemia‐meningeal cell co‐culture experiments and enhanced the efficacy of cytarabine in targeting leukaemia cells in the meninges in vivo. This work identifies the CXCR4/CXCL12 axis as an important regulator of intercellular interactions within the CNS leukaemia niche and supports further testing of the therapeutic efficacy of CXCR4 antagonists in overcoming CNS niche‐mediated chemoresistance.
Design and application of a customizable relational DataBase to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases
Authors: Journe‐Mallet Isabelle , Gouju Julien , Etcharry‐Bouyx Frédérique , Chauvire Valérie , Guillet‐Pichon Virginie , Scherer‐Gagou Clarisse , Prundean Adriana , Godard Sophie , Lecluse Aldéric , Cassereau Julien , Verny Christophe , Letournel Franck , Codron Philippe 
Published: December 2022

AbstractThe diagnosis of neurodegenerative diseases is made complex by the heterogenous phenotype of the patients and the regular occurrence of concomitant pathology. Studying clinicopathological correlations in autopsy series is a central approach to improve pathological prediction in clinical practice. However, such method requires a wealth of information, and the use of standard spreadsheet software is hardly suitable. To overcome this constraint, we designed a customizable and freely available neuropathology form with 456 data entry fields driven by an open‐source DataBase Management Systems (DBMS) using Structured Query Language (SQL). This approach allowed us to optimize the compilation of clinical and pathological data from our brain collection (264 autopsied patients, 22,885 data points). Information was then easily retrieved using general and specific queries, facilitating the analysis of demographics, clinicopathological correlations, and incidental and concomitant proteinopathies. Tau, amyloid‐β and α‐synuclein incidental pathology was observed in respectively 78.1%, 42.8%, and 10.7% of all the patients. These proportions increased with age, reaching 100% for Tau pathology after 80. Concomitant proteinopathy was observed in 46.4% of the patients diagnosed with neurodegenerative diseases and prion disease. We observed a particularly high rate of co‐pathology in patients with Dementia with Lewy bodies (81.3% of associated Tau and amyloid‐β pathology) and Creutzfeldt–Jakob disease (68.4% of associated Tau pathology). Finally, we used specific queries to identify old cases that could meet newly defined neuropathological criteria and revised the diagnosis of a 90‐year‐old patient to LATE Stage 2. Increasing our understanding of clinicopathological correlations in neurodegenerative diseases is crucial given the implications in clinical diagnosis, biomarker identification and targeted therapies assessment. The precise characterization of clinical and pathological data of autopsy series remains a central approach but the large amount of generated data should encourage a more systematic use of DBMS.
Positive effects of ketogenic diet on weight control in children with obesity due to Prader–Willi syndrome
Authors: Teke Kısa Pelin , Güzel Orkide , Arslan Nur , Demir Korcan 
Published: December 2022

AbstractObjectivePrader–Willi Syndrome (PWS) is the most common genetic cause of obesity. Prevention and management of obesity, which represents the main cause of morbidity and mortality in these patients, is essential. Ketogenic diet (KD) is used in the treatment of various disorders, however knowledge of its effect in PWS is lacking. The present study assesses the characteristics of patients with PWS who were on KD.Design and PatientsThis is a retrospective, cross‐sectional descriptive study investigating the subjects with PWS, who had received KD for at least 6 months.ResultsTen patients with PWS [median age 52.5 (47–77) months] complied with KD. The median treatment period was 16.5 [11–52] months. Of the daily calorie, 75%–85% were from fat, and 15%–25% from protein + carbohydrate. The baseline body weight standard deviation (SD) score before diet therapy was 2.10 [−1.11–4.11], whereas it was 0.05 [−0.92–1.2] at final evaluation (p = .007). The baseline median BMI SD score before diet therapy was 3.05 [−0.21–3.72], whereas it was 0.41 [−0.87–1.57] at final evaluation (p = .002). The height SD score remained unchanged. Mild hypercholesterolaemia was the most common biochemical abnormality during treatment with KD.ConclusionOur results indicate that KD might have a favourable effect on weight management in PWS.
Childhood and children's migration in the era of COVID‐19: A case study of Zimbabwean children/young people's migration to South Africa
Authors: Madziva Roda , Mahiya Innocent , Nyoni Chamunogwa 
Published: December 2022

AbstractThis paper draws on research with a group of Zimbabwean orphaned young people. It explores their experiences of migrating to South Africa during the COVID‐19 period when official borders were closed. It draws attention to the complexities of south–south migration in the era of COVID‐19 in a way that situates the orphaned child migrants as having contradictory, fluid identities that are simultaneously victimised, agentic and infinitely more complex than the dominant binary representation of adult/child.
The maximum phonation time as marker for voice treatment efficacy: A network meta‐analysis
Authors: Barsties v. Latoszek Ben , Watts Christopher R. , Schwan Katharina , Hetjens Svetlana 
Published: December 2022

AbstractPurposeThere is a diversity in treatment approaches for voice therapy in which aerodynamic treatment effects between the approaches are lacking. The evidence of voice treatments on the maximum phonation time (MPT) was quantified using the statistical approach of a network meta‐analysis (NMA).Data SourcesThree databases and manual search from inception to November 2021 were evaluated.Study SelectionStudies were considered which were reports of randomised controlled/clinical trials (RCT) evaluating the efficacy of a specific voice therapy treatment using MPT as an outcome measure in adult participants with voice disorders. Studies were excluded if participants had been diagnosed with neurological‐motor‐speech disorders or who were vocally healthy. Furthermore, no medical, pharmacological, or technical instrumental treatments were used.Data Extraction and SynthesisPreferred Reporting Items for systematic reviews and meta‐analyses extension statement guidelines were followed. Two reviewers independently screened citations, extracted data, and assessed risk of bias using PEDro scale. Random effects model was used for meta‐analysis.ResultsWe identified finally 12 RCT studies (treatment groups n = 285, and control group without an intervention n = 62). Eight interventions were evaluated. The only effective intervention with a significant effect was vocal function exercises (VFE) (mean pre–post difference 6.16 s, 95% confidence interval, 1.18–11.13 s).Conclusions and RelevanceVFE effectively improved MPT from pre‐ to post‐treatment in comparison with other voice interventions which were identified in the present NMA. Further high‐quality intervention studies with large samples sizes, multidimensional measures, and homogeneous groups of dysphonia are needed to support evidence‐based practice in laryngology.
Problems and Mysteries of the Many Languages of Thought
Authors: Mandelbaum Eric , Dunham Yarrow , Feiman Roman , Firestone Chaz , Green E. J. , Harris Daniel , Kibbe Melissa M. , Kurdi Benedek , Mylopoulos Myrto , Shepherd Joshua , Wellwood Alexis , Porot Nicolas , Quilty‐Dunn Jake 
Published: December 2022

Abstract“What is the structure of thought?” is as central a question as any in cognitive science. A classic answer to this question has appealed to a Language of Thought (LoT). We point to emerging research from disparate branches of the field that supports the LoT hypothesis, but also uncovers diversity in LoTs across cognitive systems, stages of development, and species. Our letter formulates open research questions for cognitive science concerning the varieties of rules and representations that underwrite various LoT‐based systems and how these variations can help researchers taxonomize cognitive systems.
Responding to external accountability in high‐performing, high‐capacity public secondary schools in Chile
Authors: Montecinos Carmen , Cortez Mónica , Zett Isabel , Chávez Sofía 
Published: December 2022

AbstractThe qualitative study on which this article reports explored how senior leaders, mathematics and Spanish language teachers (N = 72) in four high‐performing, high‐poverty, public secondary schools in Chile enact performance‐based accountability policies related to standardised assessments. These four public schools were selected because prior to when the study was conducted all were part of the Bicentennial Schools Programme led by the Ministry of Education from 2010 to 2014. The aim of the programme was to develop effective secondary schools to serve low‐income students. A thematic analysis of data produced through individual and group interviews and observations of departmental meetings shows that the enactment of performance‐based accountability involved two dimensions of learning‐centred leadership, distributed among senior leaders and department heads. An aim shared by parents, students, teachers and senior leaders was to ensure students' access to, and completion of, studies in higher education. Attaining good scores in national standardised SIMCE tests was key to meeting the vision. Collective trust among all actors and macro level trust in standardised testing served as a resource for strong collaboration to improve instruction and learning as well as teachers' collective efficacy. The discussion focuses on school‐level practices and policy‐level decisions that create conditions for the effective use of information produced from standardised assessments. A key point supported by our findings is that successful performance in external assessments is resourced by, and fosters, trust formation in schools.
Strategic leadership and firm performance: The mediating role of ambidexterity in professional services small‐ and medium‐sized enterprises
Authors: Ambilichu Charles Anyeng , Omoteso Kamil , Yekini Liafisu Sina 
Published: December 2022

AbstractThe role of strategic leadership is pivotal in determining a firm's direction and shaping its processes, competencies and performance. Strategic leadership also develops, deploys and reconfigures the firm's ambidextrous capabilities (such as innovativeness, competiveness and adaptability) that influence performance. Using responses from 315 UK small‐ and medium‐sized accountancy firms, this study empirically investigates the extent to which the direct influence of strategic leadership on performance is mediated by the firm's ambidextrous orientation. With a variance accounted for of 57.78%, the results show that ambidexterity has a partial mediating effect on the relationship between strategic leadership and the performance of accountancy firms. Also, our findings show that the perception of environmental dynamism does not influence the ambidextrous orientation of these accountancy firms. In addition, increased firm's age does not necessarily lead to decreased performance resulting from inertia.
Borrowing from Keynes' A Treatise on Probability: A non‐probabilistic measure of uncertainty for scenario planning
Authors: Derbyshire James , Feduzi Alberto , Runde Jochen 
Published: December 2022

AbstractScenario planning is a tool used to formulate contingent but potentially impactful futures to aid strategic decision‐making. A crucial element of many versions of scenario planning is an assessment of levels of uncertainty about the broad drivers of change within the system under consideration. Despite the importance of this element, the scenario planning literature is largely silent on the appropriate conception of uncertainty to use, exactly what it attaches to and how it might be measured. This paper seeks to fill this gap by advancing a non‐probabilistic measure of uncertainty based on the concept of evidential weight drawn from the economist John Maynard Keynes' 1921 A Treatise on Probability.