bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms
Authors: Buck Amanda M. , Deitchman Amelia N. , Takahashi Saki , Lu Scott , Goldberg Sarah A. , Hoh Rebecca , Williams Meghann C. , Kerbleski Marian , Deveau Tyler-Marie , Munter Sadie E. , Lombardo James , Wrin Terri , Petropoulos Christos J. , Durstenfeld Matthew S. , Hsue Priscilla Y. , Kelly J. Daniel , Greenhouse Bryan , Martin Jeffrey N. , Deeks Steven G. , Peluso Michael J. , Henrich Timothy J. 
Published: March 2023

ABSTRACTBackgroundThe associations between longitudinal dynamics and the breadth of SARS-CoV-2 neutralizing antibody response with various Long COVID (LC) phenotypes prior to vaccination are not known. The capacity of antibodies to cross neutralize a variety of viral variants may be associated with ongoing pathology and persistent symptoms.MethodsWe measured longitudinal neutralizing and cross-neutralizing antibody responses to pre- and post-SARS-CoV-2 Omicron variants in participants infected during the early waves of the COVID-19 pandemic, prior to wide-spread rollout of SARS-CoV-2 vaccines. Cross sectional regression models adjusted for various clinical covariates and longitudinal mixed effects models were used to determine the impact of the breadth and rate of decay of neutralizing responses on the development of Long COVID symptoms in general, as well as LC phenotypes.ResultsWe identified several novel relationships between SARS-CoV-2 antibody neutralization and the presence of LC symptoms. Specifically, we show that, although neutralizing antibody responses to the original, infecting strain of SARS-CoV-2 were not associated with LC in cross-sectional analyses, cross-neutralization ID50 levels to the Omicron BA.5 variant approximately 4 months following acute infection was independently and significantly associated with greater odds of LC and with persistent gastrointestinal and neurological symptoms. Longitudinal modeling demonstrated significant associations in the overall levels and rates of decay of neutralization capacity with LC phenotypes. A higher proportion of participants had antibodies capable of neutralizing Omicron BA.5 compared with BA.1 or XBB.1.5 variants.ConclusionsOur findings suggest that relationships between various immune responses and LC are likely complex but may involve the breadth of antibody neutralization responses.SummarySARS-CoV-2-specific antibody neutralization of Omicron BA.5 variant approximately 4 months following acute infection with wild-type virus prior to vaccination was independently and significantly associated with greater odds of distinct Long COVID phenotypes.
Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia
Authors: Harper Luke , de Boer Sterre , Lindberg Olof , Lätt Jimmy , Cullen Nicholas , Clark Lyles , Irwin David , Massimo Lauren , Grossman Murray , Hansson Oskar , Pijnenburg Yolande , McMillan Corey T. , Santillo Alexander F 
Published: March 2023

AbstractBackgroundFrontotemporal dementia is the second most common form of early onset dementia (< 65 years). Despite this there are few known disease modifying factors. The anterior cingulate is a focal point of pathology in behavioural variant frontotemporal dementia. Sulcation of the anterior cingulate is denoted by the presence of a paracingulate sulcus, a tertiary sulcus developing, where present during the third gestational trimester and remaining stable throughout life. This study aims to examine the impact of right paracingulate sulcal presence on the expression and prognosis of behavioural variant Frontotemporal Dementia.MethodsThis retrospective analysis drew it’s population from two clinical samples recruited from memory clinics at University Hospitals in The United States of America and The Netherlands. Individuals with sporadic behavioural variant Frontotemporal Dementia were enrolled between 2004 and 2022 and followed up for an average of 7.71 years. T1-MRI data were evaluated for hemispheric paracingulate sulcal presence in accordance with an established protocol by two blinded raters. Outcome measures included age at onset, survival, cortical thickness, and Frontotemporal Lobar Degeneration-modified Clinical Dementia Rating determined clinical disease progression.ResultsThe study population consisted of 186 individuals with sporadic behavioural variant Frontotemporal Dementia, (113 males and 73 females) mean age 63.28 years (SD 8.32). The mean age at onset was 2.44 years later in individuals possessing a right paracingulate sulcus (60.2 years (SD 8.54)) versus individuals who did not (57.76 (8.05)), 95% CI >0.41,P= 0.02. Education was not associated with age at onset (β = -0.05,P=0.75). Presence of a right paracingulate sulcus was associated with a 119% increased risk of death per year after age at onset (HR 2.19, CI [1.21 - 3.96],P<0.01), whilst the mean age at death was similar for individuals with a present and absent right paracingulate sulcus (P= 0.7). Right paracingulate sulcal presence was not associated with baseline cortical thickness.ConclusionRight paracingulate sulcal presence is associated with disease expression and survival in sporadic behavioural variant Frontotemporal Dementia. Findings provide evidence of neurodevelopmental brain reserve in behavioural variant Frontotemporal Dementia which may be important in the design of trials for future therapeutic approaches.
Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases
Authors: Técher Hervé , Gopaul Diyavarshini , Heuzé Jonathan , Leray Baptiste , Vernet Audrey , Mettling Clément , Moreaux Jérôme , Lin Yea-Lih , Pasero Philippe 
Published: March 2023

AbstractOncogene-induced senescence (OIS) is a tumor-suppressive mechanism that arrests cell proliferation in response to oncogene-induced replication stress (RS). OIS also depends on the cGAS-STING pathway, which detects cytosolic DNA and promotes the expression of type I interferons (IFN) and pro-inflammatory cytokines. Whether and how the RS and IFN responses cooperate to promote OIS is currently unknown. Here, we show that the MRE11 nuclease promotes OIS in immortalized human fibroblasts overexpressing the H-RASV12oncogene both by slowing replication forks and by activating the cGAS-STING pathway in response to RS. Interestingly, overexpression of TREX1, the major nuclease degrading cytosolic DNA, prevented RAS-induced senescence. In contrast, overexpression of a dominant negative mutant of TREX1 was sufficient to induce senescence in human fibroblasts, even in the absence of H-RASV12induction. Collectively, these data suggest that the RS and IFN responses in OIS are functionally linked through a process involving the nucleases MRE11 and TREX1.
Polygenic risk associations with developmental and mental health outcomes in childhood and adolescence: A systematic review
Authors: Moyakhe L.B. , Dalvie S. , Mufford M.S. , Stein D.J. , Koen N. 
Published: March 2023

AbstractBackgroundNeurodevelopmental and mental health disorders in childhood constitute an emerging global concern, with adverse sequelae which span children’s physical, psychological and social well-being. The aetiology of these disorders is likely complex, multifactorial and polygenic. Polygenic risk scores (PRS), an estimate of an individual’s genetic liability toward a disorder, have been increasingly used in psychiatric research to explore genetic associations with disorders of interest. However, limited work delineates polygenic associations with development and mental health in childhood populations.We aimed to systematically review existing literature on associations between genetic risk (as measured by PRS) and neurodevelopmental and mental health outcomes in childhood and adolescence.MethodsFollowing the recommended Preferred Reporting Items for Meta-Analyses (PRISMA) guidelines, databases were searched using key search terms. The search commenced in March 2021 and concluded in June 2021. The studies eligible for inclusion were full-text articles investigating polygenic risk associations with neurodevelopmental and/or mental health outcomes in childhood or adolescence.ResultsFourteen studies were eligible for inclusion in this systematic review. The association between higher PRS for attention-deficit/hyperactivity disorder (ADHD) and adverse developmental/mental health outcomes in childhood and adolescence was reported by five studies. Additionally, associations between PRS for bipolar disorder or major depressive disorder and adverse outcomes of interest were also described by two studies; and two studies highlighted associations between schizophrenia PRS and mental health disorders in childhood. The remaining studies highlighted shared polygenic contributions between and within NDDs and mental health disorders in children.ConclusionThe findings of this systematic review suggest that PRS for neurodevelopmental and mental health disorders may associate with adverse neurodevelopmental and mental health outcomes from early childhood to adolescence. In addition, these associations seemed not to be phenotype-specific, suggesting potential shared genetic variation across the phenotypes of interest.
Embracing supply chain digitalization and unphysicalization to enhance supply chain performance: a conceptual framework
Authors: Perano Mirko , Cammarano Antonello , Varriale Vincenzo , Del Regno Claudio , Michelino Francesca , Caputo Mauro 
Published: March 2023

PurposeThe paper presents a research methodology that could be used to carry out a systematic literature review on the current state of the art of the technological development in the field of the digitalization and unphysicalization of supply chains (SCs). A three-dimensional conceptual framework focusing on the relationship between Digital Technologies (DTs), business processes and SC performance is presented. The study identifies the emerging practices and areas of SC management that could be positively affected by the implementation of DTs. With this in mind, the emerging practices have a high probability to be considered future best practices.Design/methodology/approachA systematic literature review was conducted on DTs in SC management. The methodology used aims to algorithmically and objectively standardize the information incorporated into thousands of scientific documents. Selected papers were analyzed to investigate the recent literature on SC digitalization and unphysicalization. A total of 87 DTs were selected to be analyzed and subsequently grouped into 11 macro-categories. 17 business processes linked to SC management are taken into account and 17 different impacts on SC management are presented. From a set of 1,585 papers, 5,060 emerging practices were collected and singularly summarized combining DT, business process and impact on SC performance.FindingsA unique analytical perspective provided represents an important evolution when trying to organize the current literature on SC management. The widely used DTs in the practices and the most considered business processes and impacts are highlighted and described. The three-dimensional conceptual framework is graphically represented to allow for the emergence of the best combinations of DT, business process and impact on SC performance. These combinations suggest the most promising areas for the implementation of the emerging practices for SC digitalization and unphysicalization. Additional findings identify and define the most important contexts in which Big Data contributes to SC performance.Originality/valueThe research methodology used is offering progress through which to systemize the current practices as well as detect the potential of digitalization and unphysicalization under the three-dimensional conceptual framework. The paper provides a structured proposal for promising future research directions, assuming that the five research gaps as findings of this research could be the basis for prescriptions, as well as a future research agenda and theory development. Moreover, this research contributes to current managerial issues concerning SC management, referred to data and information management, efficiency and productivity of SC processes, market performance, SC relationship management and risk management in SC.
Russia–Ukraine conflict and its impact on global inflation: an event study-based approach
Authors: Maurya Prince Kumar , Bansal Rohit , Mishra Anand Kumar 
Published: March 2023

PurposeThis study investigates how the conflict between Russia and Ukraine impacts global inflation.Design/methodology/approachThe study uses monthly consumer price index (CPI) data from 60 countries for 30 months, from January 2020 to June 2022. An event study methodology has been employed to check abnormal variation in the CPI, after classifying country-specific monthly data into nine groups.FindingsThe outcome revealed that Russia's full-scale invasion of Ukraine triggered inflation globally. However, the severity of inflation in the sample countries is determined by their geographical proximity and trading activity with the countries in conflict. A significant rise in inflation was observed among major European economies during the invasion. As the war continues, the increase in the price of essential commodities is evident worldwide.Originality/valueThe war literature till now has concentrated on stock markets, energy markets, exchange rates and precious metals. Since no previous research has attempted to quantify the abnormal effect of the war on domestic and global inflation, the current study will shed much-needed light on the subject.
Temperature drives the coordination between above‐ground nutrient conservation and below‐ground nutrient acquisition in alpine coniferous forests
Authors: Ding Junxiang , Ge Wenjing , Liu Qing , Wang Qitong , Kong Deliang , Yin Huajun 
Published: March 2023

Abstract

Above‐ground nutrient conservation via resorption processes and below‐ground nutrient acquisition from soils are two important mechanisms for plants to maintain nutrition and ecosystem functions. However, the mechanism by which plants coordinate these two nutrient strategies, especially for ectomycorrhizal (ECM)‐dominated conifers in alpine forests, remains unclear.

We investigated the relationships between above‐ground nutrient conservation and below‐ground nutrient acquisition and their environmental drivers by measuring leaf nutrient (i.e. nitrogen [N] and phosphorous [P]) resorption efficiency, resource foraging‐ and uptake‐related root morphological (root diameter [RD], specific root length [SRL]/area [SRA]) and physiological (root tissue density [RTD], root N and P concentration) traits, mycorrhizal colonization rate (MCR), rhizosphere effect on soil N and P cycling, and environmental factors of 40 ECM coniferous populations on the eastern Tibetan Plateau, China.

Our results showed that with increasing leaf nutrient (N and P) resorption efficiency, conifers shifted from depending on the ‘outsourcing’ strategy by mycorrhizal fungi (high MCR) to relying on the ‘do‐it‐yourself’ strategy of root mining (high rhizosphere effect on N‐ and P‐mining‐related enzyme activities) rather than on root foraging (high SRL and SRA) and preferred more conservative roots (high RTD and low root N and P concentrations). Temperature was the main factor driving a negative relationship of ECM fungi foraging, root uptake and a positive relationship of root mining with leaf nutrient resorption, while precipitation resulted in a decoupled relationship between root foraging and leaf nutrient resorption.

Our findings demonstrate temperature‐driven and diverse collaborations (e.g. trade‐off or synergy) between below‐ground nutrient acquisition and above‐ground nutrient conservation strategies in alpine ECM conifers and highlight that the preference for below‐ground nutrient acquisition strategies could influence the above‐ground nutrient utilization strategy. This is insightful for a holistic understanding of the adaptation and responses of alpine forests to climatic change.

Read the free Plain Language Summary for this article on the Journal blog.
Pulp volume quantification methods in cone‐beam computed tomography for age estimation: A critical review and meta‐analysis
Authors: Barbosa Marcella Guedes , Franco Ademir , de Oliveira Renata Dantas Barreto , Mamani Mariela Peralta , Junqueira José Luís Cintra , Soares Mariana Quirino Silveira 
Published: March 2023

AbstractThe secondary dentin deposition that occurs after the tooth formation process results in a decrease in pulp cavity volume in adolescents and adults. The purpose of this critical review was to correlate pulpal and/or dental volume on cone‐beam computed tomography (CBCT) with chronological age approximation. A subobjective was to investigate which methodology and CBCT technical parameters would be most appropriate to evaluate this correlation. This critical review followed the PRISMA guidelines, and it was conducted by a search through PubMed, Embase, SciELO, Scopus, Web of Science, Cochrane Library databases, as well as gray literature. Primary studies that used pulp volume, or pulp chamber to tooth volume ratio measured using CBCT were included. Seven hundred and eight indexed and 31 non‐indexed records were identified. A qualitative analysis was performed including 25 selected studies with a total of 5100 individuals, age ranging from 8 to 87 years without sex predilection. The most used method was pulp volume/tooth volume. CBCT voxel size ranged between 0.09 and 0.5. Manual segmentation associated with threshold algorithms was used in most of the studies. Correlation between the pulp volume/tooth volume ratio was moderate: −0.66 for the upper central incisors, −0.59 for upper canines and −0.56 for lower canines. High heterogeneity was observed among the studies. It is concluded that pulp volume should be used with caution in age estimation. Evidence supports the preferable use of upper incisors with pulp volume/tooth volume ratio for age estimation. There is not enough evidence that voxel size interferes in age estimation by pulp volume.
Effects of language mismatch in automatic forensic voice comparison using deep learning embeddings
Authors: Sztahó Dávid , Fejes Attila 
Published: March 2023

AbstractIn forensic voice comparison, deep learning has become widely popular recently. It is mainly used to learn speaker representations, called embeddings or embedding vectors. Speaker embeddings are often trained using corpora mostly containing widely spoken languages. Thus, language dependency is an important factor in automatic forensic voice comparison, especially when the target language is linguistically very different from that the model is trained on. In the case of a low‐resource language, developing a corpus for forensic purposes containing enough speakers to train deep learning models is costly. This study aims to investigate whether a model pre‐trained on multilingual (mostly English) corpus can be used on a target low‐resource language (here, Hungarian), not represented by the model. Often multiple samples are not available from the offender (unknown speaker). Samples are therefore compared pairwise with and without speaker enrollment for suspect (known) speakers. Two corpora are used that were developed especially for forensic purposes and a third that is meant for traditional speaker verification. Speaker embedding vectors are extracted by the x‐vector and ECAPA‐TDNN techniques. Speaker verification was evaluated in the likelihood‐ratio framework. A comparison is made between the language combinations (modeling, LR calibration, and evaluation). The results were evaluated by Cllrmin and EER metrics. It was found that the model pre‐trained on a different language but on a corpus with a significant number of speakers can be used on samples with language mismatch. Sample duration and speaking style also seem to affect the performance.
Automatic detection of irregular vanishing and reappearing parts of objects in two interwoven sequences: A visual mismatch negativity study
Authors: Csikós Nóra , Petro Bela , Kojouharova Petia , Scheiling Katalin , Gaál Zsófia Anna , Czigler István 
Published: March 2023

AbstractThe cognitive system automatically develops predictions on the basis of regularities of event sequences and reacts to the violation of these predictions. In the visual modality, the electrophysiological signature of this process is an event‐related potential component, the visual mismatch negativity (vMMN). So far, we have no data, whether the system underlying vMMN is capable of dealing with more than one event sequence simultaneously. To disclose this aspect of the capacity of the system, in a passive oddball paradigm, we presented two interwoven sequences. The stimuli were objects (diamond patterns with their diagonals), one of the sequences was presented to the left side and the other to the right side of the visual field. From time to time, two parallel lines of the diamonds disappeared (OFF event) and then reappeared (ON event). The frequently vanishing pair of lines on the left side (standard) was identical to the rarely vanishing lines of the objects on the right side (deviant) and vice versa. We found that deviant ON events elicited vMMN only for left‐side deviants and deviant OFF events elicited vMMN only for right‐side deviants. The standardized low resolution brain electromagnetic tomography (sLORETA) source localization showed vMMN sources both in posterior visual structures and in anterior locations, and activity was stronger in the hemisphere contralateral to the deviant event. According to the results, the system underlying vMMN is capable of dealing with two sequences, but within a sequence, it detected only one type (either OFF or ON) of deviancy.