bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid optical turbulence models using machine-learning and local measurements
Authors: Jellen Christopher , Nelson Charles , Burkhardt John , Brownell Cody 
Published: May 2023

Accurate prediction of atmospheric optical turbulence in localized
environments is essential for estimating the performance of free-space
optical systems. Macro-meteorological models developed to predict
turbulent effects in one environment may fail when applied in new
environments. However, existing macro-meteorological models are
expected to offer some predictive power. Building a new model from
locally measured macro-meteorology and scintillometer readings can
require significant time and resources, as well as a large number of
observations. These challenges motivate the development of a
machine-learning informed hybrid model framework. By combining a
baseline macro-meteorological model with local observations, hybrid
models were trained to improve upon the predictive power of each
baseline model. Comparisons between the performance of the hybrid
models, selected baseline macro-meteorological models, and
machine-learning models trained only on local observations, highlight
potential use cases for the hybrid model framework when local data are
expensive to collect. Both the hybrid and data-only models were
trained using the gradient boosted decision tree architecture with a
variable number of in situ
meteorological observations. The hybrid and data-only models were
found to outperform three baseline macro-meteorological models, even
for low numbers of observations, in some cases as little as one day.
For the first baseline macro-meteorological model investigated, the
hybrid model achieves an estimated 29% reduction in the mean absolute
error using only one day-equivalent of observation, growing to 41%
after only two days, and 68% after 180 days-equivalent training
data. The data-only model generally showed similar, but slightly lower
performance, as compared to the hybrid model. Notably, the hybrid
model’s performance advantage over the data-only model dropped below
2% near the 24 days-equivalent observation mark and trended towards 0%
thereafter. The number of days-equivalent training data required by
both the hybrid model and the data-only model is potentially
indicative of the seasonal variation in the local microclimate and its
propagation environment.
Effective immuno-therapeutic treatment of Canine Leishmaniasis
Authors: Ramos Rafael Antonio Nascimento , Giannelli Alessio , Fasquelle François , Scuotto Angelo , Betbeder Didier 
Published: May 2023

Background
Canine Leishmaniasis (CanL) caused by the L. infantum species is one of the biggest threats to the health of the South American canine population. Chemotherapeutics currently used for the treatment of CanL fail to induce a total parasite clearance while inducing numerous side effects. As CanL is an immunomodulated disease, the use of immuno-treatments should strengthen the deficient immune response of infected dogs. In this study, we evaluated a nasally administered immunotherapy in dogs naturally infected with L. infantum (stage 2), with both visceral and cutaneous manifestations. Noteworthy, some of them were also infected by other parasites (E. canis, D. immitis, A. platys), what worsen their chance of survival.

Methodology/Principal findings
The treatment was based on 2 intranasal (IN.) administrations of a killed L. infantum parasite loaded into maltodextrin nanoparticles, which treatment was compared with the classical oral administration of Miltefosine (2 mg/kg) for 28 days, as well as a combination of these 2 treatments. The results showed that two IN administrations significantly reduced the serology, and were at least as efficient as the chemotherapy to reduce the skin and bone marrow parasite burden, as well as clinical scores, and that unlike Miltefosine treatments, this nasally administered nanoparticle vaccine was without side effects.

Conclusions
These results confirm the feasibility of a simple therapeutic immuno-treatment against L. infantum infected dogs, which is a promising tool for future developments.
Association between low internal health locus of control, psychological distress and insulin resistance. An exploratory study
Authors: Eriksson Maria C. M. , Lundgren Jesper , Hellgren Margareta , Li Ying , Björkelund Cecilia , Lindblad Ulf , Daka Bledar 
Published: May 2023

AimTo assess the hypothesis that low internal health locus of control (IHLC) and psychological distress (PD) are associated with insulin resistance.Materials and methodsIn 2002–2005, a random population sample of 2,816 men and women aged 30–74 years participated (76%) in two municipalities in southwestern Sweden. This study included 2,439 participants without previously known diabetes or cardiovascular disease. IHLC was measured by a global scale and PD was measured by the 12-item General Health Questionnaire. Insulin resistance was estimated using HOMA-ir. General linear models were used to estimate differences in HOMA-ir between groups with low IHLC, PD, and both low IHLC and PD, respectively.ResultsFive per cent (n = 138) had both PD and low IHLC, 62 per cent of participants (n = 1509) had neither low IHLC nor PD, 18 per cent (n = 432) had PD, and 15 per cent (n = 360) low IHLC. Participants with both low IHLC and PD had significantly higher HOMA-ir than participants with neither low IHLC nor PD (Δ = 24.8%, 95%CI: 12.0–38.9), also in the fully adjusted model (Δ = 11.8%, 95%CI: 1.5–23.0). Participants with PD had significantly higher HOMA-ir (Δ = 12%, 95%CI: 5.7–18.7), but the significance was lost when BMI was included in the model (Δ = 5.3%, 95%CI:0.0–10.8). Similarly, participants with low IHLC had significantly higher HOMA-ir (Δ = 10.1%, 95%CI: 3.5–17.0) but the significance was lost in the fully adjusted model (Δ = 3.5%, 95%CI: -1.9–9.3).ConclusionsInternal health locus of control (IHLC) and psychological distress (PD) were associated with insulin resistance. Especially individuals with both PD and low IHLC may need special attention.
Characteristics of cardiopulmonary exercise testing in patients with combined post- and pre-capillary pulmonary hypertension due to left heart disease
Authors: Goda Ayumi , Yanagisawa Yoshiaki , Takeuchi Shinsuke , Takeuchi Kaori , Kikuchi Hanako , Inami Takumi , Kohno Takashi , Satoh Toru , Soejima Kyoko 
Published: May 2023

Background
Pulmonary hypertension (PH) is a common and morbid complication of left heart disease (LHD), comprising two subtypes: (1) isolated post-capillary pulmonary hypertension (Ipc-PH) and (2) combined post-capillary and pre-capillary pulmonary hypertension (Cpc-PH). Knowledge regarding the physiological characteristics that distinguish Cpc-PH, which has a worse prognosis, from Ipc-PH remains limited. Therefore, this study aimed to assess the utility of cardiopulmonary exercise testing (CPET) variables in detecting Cpc-PH.

Methods and results
Among 105 consecutive patients with LHD (age: 55 ± 13 years; male/female = 79/26) who underwent right heart catheterization and CPET, 45 (43%) were classified as PH-LHD (mean pulmonary artery pressure >20 mmHg). Ipc-PH (n = 24) was defined as pulmonary vascular resistance (PVR) ≤ 3 WU and Cpc-PH (n = 21) as PVR > 3 WU. Patients with Cpc-PH had a significantly lower peak partial pressure of carbon dioxide (PETCO2) (Non-PH/Ipc-PH/Cpc-PH = 38.2 ± 6.6 vs. 38.3 ± 6.0 vs 33.0 ± 4.4 mmHg, p = 0.006), higher VE vs. VCO2 slope (Non-PH/Ipc-PH/Cpc-PH = 33.0 [28.3, 36.6] vs. 32.5 [28.1, 37.8] vs. 40.6 [33.6, 46.1], p = 0.007), and lower ΔVO2/ΔWR (Non-PH/Ipc-PH/Cpc-PH = 8.5 ± 1.4 vs. 8.0 ± 1.7 vs. 6.8 ± 2.0 mL/min/watt, p = 0.001) than those with Ipc-PH and non-PH. Using multivariable logistic regression analysis, CPET variables were found to be independent predictors of Cpc-PH (lower peak PETCO2: odds ratio, 0.728 [95% confidence interval {CI}: 0.616–0.840], p = 0.003 and lower ΔVO2/ΔWR: odds ratio, 0.747 [95% CI: 0.575–0.872], p = 0.003).

Conclusion
From our exploratory analysis, CPET variables, especially in the lower peak PETCO2 and lower ΔVO2/ΔWR, were associated with Cpc-PH in patients with left heart disease.
Living with a diagnosis of Placenta Accreta Spectrum: Mothers’ and Fathers’ experience of the antenatal journey and the birth
Authors: Bartels Helena C. , Horsch Antje , Cooney Naomi , Brennan Donal J. , Lalor Joan G. 
Published: May 2023

Objective
Much research into Placenta Accreta Spectrum (PAS) has focussed on the associated maternal morbidity and mortality. However, mothers’ and fathers’ lived experiences of the aftermath of a diagnosis of PAS up to the birth and beyond has received little attention. Therefore, the aim of this study was to increase our understanding of the psychological consequences of PAS on women and their partners during pregnancy, up to and including the birth.

Methods
In-depth interviews were conducted with 29 participants; 6 couples were interviewed together (n = 12), 6 couples were interviewed separately (n = 12), and 5 women were interviewed without their partner. Data from the antenatal and intrapartum periods are presented. Couples were eligible for inclusion if they had a diagnosis of PAS within the previous 5 years. An Interpretative Phenomenological Analysis approach was used to gather and analyse data. Virtual interviews were conducted over a 3-month period from February to April 2021.

Results
Themes emerged relating to two distinct timepoints, the antenatal period and birth. The antenatal period had two main themes: the first antenatal main theme was “Living with PAS”, which had two sub-themes: “Lack of knowledge of PAS” and “Experiences of varied approaches to care”. The second antenatal main theme was “Coping with uncertainty”, which had two sub-themes of “Getting on with it”, and “Emotional toll”. Relating to birth, two main themes emerged. The first main theme was “A traumatic experience”, with three sub-themes of “Saying goodbye”, “Experiencing trauma” and the “Witnessing of trauma” (by fathers). The second main theme which emerged was “Feeling safe in the hands of experts”, with two subthemes of “Safety in expert team” and “Relief at surviving”.

Conclusions
This study highlights the significant psychological consequences a diagnosis of PAS has on mothers and fathers, how they try to come to terms with the diagnosis and the experience of a traumatic birth, and how management within a specialist team can alleviate some of these fears.
ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis
Authors: Wang Da , Zhao Penglai , Lu Tingting , Ren Jingyao , Zhu Lihui , Han Xiaoyong , Zhang Guangming , Dong Xiaohua , Ma Haizhong , Yu Miao , Cai Hui 
Published: May 2023

Abstract
Cell-free circulating tumor DNA (ctDNA) is synthesized by tumor cells, including metastatic tumors, and circulates in the bloodstream. Evidence suggests that ctDNA is a potential predictive and prognostic biomarker for colorectal cancer (CRC), but its predictive efficacy in detecting CRC liver metastasis (CLM) remains unclear. Additionally, its utility in the clinical setting needs further investigation. We conducted a meta-analysis to determine the utility of ctDNA as a biomarker for predicting the prognosis of CLM and investigate the relationship between CLM and ctDNA positivity. A literature search was performed in electronic databases to identify relevant studies published up to March 19, 2022. We retrieved data on overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) for both ctDNA-positive and ctDNA-negative colorectal liver metastasis (CLM) patients from the selected articles. Hazard ratios (HRs) were also calculated for these survival outcomes analysis was also performed. The stability of the combined meta-analysis was verified by sensitivity analysis and publication bias evaluation. Ten trials were included, and 615 patients were evaluated. In patients with CLM, pooled HRs revealed a substantial link between ctDNA positivity and RFS/DFS. Subgroup analysis revealed that ctDNA had a prospective detection value. Sensitivity analysis and publication bias evaluation indicated stable results. Although the results on pooled HR for OS suggested that ctDNA-positive patients had a shorter survival time, their pooled HRs had a relatively evident heterogeneity, and sensitivity analysis and publication bias evaluation indicated that pooled HRs were extremely unstable. In conclusion, our results demonstrate that ctDNA appears to be a prognostic biomarker for resectable CLM patients.
Семантические горизонты понятия «смех» в русской культуре
Authors: Прозоров Валерий Владимирович 
Published: May 2023

Аннотация
Семантические горизонты понятия «смех» в русской культуре ценностно ориентированы. С большой долей уверенности обозначаются пределы смеха желательного / нежелательного, приемлемого / неприемлемого, уместного / неуместного. Смех избирательно любит своих, близких, связанных взаимной симпатией, сходством вкусов, привычек, взглядов на жизнь. Сохраняют силу испытанные смеховые предпочтения, запечатленные в русской словесности. На заметной периферии обнаруживает себя смех высокомерный, оскорбительный и злорадный. Не в чести самодовольная усмешка и язвительная ухмылка. Всегда дорого ценится смех духоподъемный, искренний и проникновенно добрый, исподволь отзывающийся светлой грустью. Для более четкого выявления примет национальной специфики смеха необходима реализация разносторонних кросс-культурных исследований.
Bott-Chern hypercohomology and bimeromorphic invariants
Authors: Yang Song , Yang Xiangdong 
Published: May 2023

AbstractThe aim of this article is to study the geometry of Bott-Chern hypercohomology from the bimeromorphic point of view. We construct some new bimeromorphic invariants involving the cohomology for the sheaf of germs of pluriharmonic functions, the truncated holomorphic de Rham cohomology, and the de Rham cohomology. To define these invariants, by using a sheaf-theoretic approach, we establish a blow-up formula together with a canonical morphism for the Bott-Chern hypercohomology. In particular, we compute the invariants of some compact complex threefolds, such as Iwasawa manifolds and quintic threefolds.
Investigation of nonlinear optical responses of organic derivative of imidazole: imidazole-2-carboxaldehyde
Authors: Lakhera Shradha , Rana Meenakshi , Devlal Kamal 
Published: May 2023

Abstract
In the present work, we explored the nonlinear optical properties of imidazole-2-carboxaldehyde, which is an aromatic derivative of imidazole. Optimization has been performed for imidazole-2-carboxaldehyde using density functional theory with a B3LYP/6-311G basis set. To check the possible charge transfer, Mulliken charge analysis and molecular electrostatic potential analysis was performed. The chemical reactivity of the probe molecule was investigated by calculating different frontier molecular orbital parameters such that energy gap, ionization potential, electron affinity, chemical potential, electronegativity, softness, and hardness. Raman, Fourier transform infrared, and nuclear magnetic resonance analysis was also performed to study vibrational properties and UV–vis was performed to study the electronic properties of the compound. A high value of dipole moment (μ
total), polarizability (α), first-order hyperpolarizability (β), and Raman activity validates the NLO behavior of the compound. Thus, the performed computational study validates a strong candidature of imidazole-2-carboxaldehyde to be used as a non-linear optically active material in the future.
AlGaN/GaN heterostructures for high power and high-speed applications
Authors: Joshi Bhubesh Chander 
Published: May 2023

AbstractAlGaN/GaN heterostructures are one of the most promising semiconducting structures for fabricating high-speed and high-power electronic devices such as high electron mobility transistors and heterojunction bipolar transistors. Due to the lack of native substrates, these epitaxial structures are generally grown on foreign substrate materials such as sapphire, SiC and Si by using two-step growth techniques. In this paper, a few test structures along with TLM pads, FET structure, ohmic contacts and Schottky contacts have been fabricated on AlGaN/GaN heterostructure by photolithography, reactive ion etching, and e-beam metallization. Transmission line measurement has been used to calculate the sheet resistivity and contact resistance of ohmic pads. Current voltage measurement is used to test an FET structure of size 1 × 150 µm2with a gate length of 4 µm and source to drain spacing of 5 µm.
A very rare cause of hypertrygliseridemia in infancy: a novel mutation in glycerol-3-phosphate dehydrogenase 1 (GPD1) gene
Authors: Gunes Dilek , Kalaycik Sengul Ozlem , Senturk Leyli 
Published: May 2023

Abstract

Objectives
Transient infantile hypertriglyceridemia (HTGTI) is caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene. HTGTI is characterized by hypertriglyceridemia, hepatomegaly, hepatic steatosis and fibrosis in infancy. Here, we reported first Turkish HTGTI patient with a novel mutation of GPD1, having hypertriglyceridemia, hepatomegaly, growth retardation and hepatic steatosis. He is the first case who needs transfusion until 6th month in GPD1.

Case presentation
A 2-month-27-day-old boy, who had growth retardation, hepatomegaly and anemia suffered to our hospital with vomiting. Triglyceride level was 1603 mg/dL (n<150). Liver transaminases were elevated and hepatic steatosis was developed. He needed transfusion with erythrocyte suspension until 6th month. Etiology could not be elucidated by clinical and biochemical parameters. A novel homozygous c.936_940del (p.His312GlnfsTer24) variant was detected in the GPD1 gene by Clinical Exome Analysis.

Conclusions
GPD1 deficiency should be investigated in the presence of unexplained hypertriglyceridemia and hepatic steatosis in children especially in infants.
New citizenship and the negotiation of the global/local interface: reflexivity, emotions, and metapragmatics
Authors: Vitorio Raymund 
Published: May 2023

Abstract
New citizens are typically characterized as people who occupy an estuarial position between the global and the local: to simultaneously become authentic to their global provenience and rooted in their new local societies, they are expected to cautiously partake in processes of differentiation as they construct their identities. This article investigates how new citizens negotiate this seemingly untenable position to present themselves as new citizens of Singapore who have negotiated the global/local dichotomy, rendering themselves as legitimate citizens. By adopting a metapragmatic approach, the article focuses on two object-signs that new citizens commonly deploy: familial relations and passports. The analysis traces how the semiotic potential of these object-signs is mediated by accounts of emotions, which are indispensable considerations of how signs realize their semiotic potential. Through situated reflexive practices, new citizens use these object-signs to equivocally and strategically manage supposed markers of difference, which consequently enables them to claim legitimacy as Singaporeans. These identities challenge regimented views about the global and local affordances of the notion of citizenship. This expands the semiotic range of good/new citizenship, which may prove instructive in understanding variegated understandings of citizenship not just in Singapore but also in other contemporary multicultural societies.
Moderation between Religious Freedom and Harmony Concerning the Regulation on Mosque Loudspeaker: Comparison between Indonesia and Other Muslim Countries
Authors: Riyanto Waryani Fajar 
Published: May 2023

Abstract
This research explains the comparison of regulations on mosque loudspeakers between Indonesia and Muslim countries in the world. Guidelines for the use of mosque loudspeakers in Indonesia are regulated in the Instruction of the Director-General of Islamic Community Guidance at the Ministry of Religious Affairs Number 101 of 1978 concerning Guidance on the Use of Loudspeakers in Mosques and Musala and the Circular Letter of the Minister of Religion Number 5 of 2022 concerning Guidelines for the Use of Loudspeakers in Mosques and Musala. Primary data of this study includes the 1978 Instructions and the 2022 Circular Letters. Secondary data is obtained from relevant literature sources and regulations on the use of mosque loudspeakers in several Muslim countries in the world, namely Saudi Arabia, Turkey, Syria, Bahrain, United Arab Emirates, Egypt, and Malaysia. This research finds the concept of moderation of regulations on mosque loudspeakers in Indonesia. The findings of this research can be used as a guide model for drafting the contents of mosque loudspeaker regulations in several Muslim countries around the world by relying on three moderate aspects regarding the rules of time (public morals), volume (public health), and sound quality of mosque loudspeakers (public convenience).
The crystal structure of fac-tricarbonyl((pyridin-2-yl)methanamino-κ2
N,N′)-((pyridin-2-yl)methanamino-κN)rhenium(I) nitrate, C15H16O3N4Re
Authors: Ramoba Lesetja V. , Alexander Orbett T. , Malan Frederick P. , Manicum Amanda-Lee E. 
Published: May 2023

Abstract
C15H16O3N4Re, triclinic, P1̄ (no. 2), a = 7.4939(2) Å, b = 10.1316(2) Å, c = 13.8351(3) Å, α = 103.453(2)°, β = 101.992(2)°, γ = 107.880(2)°, V = 926.98(4) Å3, Z = 2, R

gt
(F) = 0.0341, wR

ref
(F
2) = 0.0861, T = 150 K.
Magnetic and porous effects on steady state and flow resistance of Burgers fluids between parallel plates
Authors: Fetecau Constantin , Rauf Abdul , Mushtaq Tahir 
Published: May 2023

AbstractSome motion problems of Burgers fluids between parallel plates are analytically and numerically investigated when magnetic and porous effects are taken into account and a differential expression of the non-trivial shear stress is prescribed on the lower plate. Closed-form expressions are determined for the non-dimensional steady state velocity and shear stress fields and the corresponding Darcy’s resistances. They are the first exact solutions for hydromagnetic motions of Burgers fluids through porous media when a differential expression of shear stress is given on the boundary. The results that have been obtained are used to get the necessary time to reach the steady state and to bring to light the influence of magnetic field and porous medium on the flow resistance of the fluid. They can immediately be particularized to provide exact solutions for similar motions of Oldroyd-B, Maxwell, second grade and Newtonian fluids. It was found that the steady state is rather obtained in the presence of a magnetic field or porous medium. In addition, the flow resistance of the fluid declines in the presence of a magnetic field and, as expected, increases through porous media.