bluuebunny/crossref_metadata_2025_split huggingface dataset:
Art Therapy-based interventions to address burnout and psychosocial distress in healthcare workers - a systematic review
Authors: Tjasink Megan , Keiller Eleanor , Stephens Madison , Carr Catherine Elizabeth , Priebe Stefan 
Published: March 2023

Abstract
Background
Burnout is a serious and growing issue for healthcare workers (HCWs) and healthcare systems across the globe. Art Therapy has demonstrated promise as a suitable intervention. This review aims to ascertain what art therapy-based interventions used to address burnout and / or psychosocial distress in HCWs have been reported in the health and social care literature and how these have been evaluated.
Methods
Six databases (PubMed, PsycINFO, MEDLINE, EMBASE, CINAHL, ProQuest Central), Google Scholar and three clinical trial registries (CENTRAL, ICTRP and ClinicalTrials.gov) were searched for studies using art therapy-based methods to engage with burnout risk or psychosocial distress in HCWs. Following screening for eligibility study characteristics and outcomes were extracted by two reviewers independently. Studies were evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Tools. Outcomes were grouped for analysis. Quantitative and qualitative results were synthesised and integrated using narrative synthesis.
Results
Twenty-seven studies, drawn from thirteen countries, spanning five continents were selected for inclusion. Fifty percent were published in the last five years, indicating growing global research in the field. Fourteen studies used quantitative research methods and thirteen used qualitative methods. A total of 1580 participants took part in the studies, with nurses most broadly represented (59%). Interventions were mostly delivered in groups (95%) and by an art therapist (70%). Heterogeneity and insufficient randomised controlled trials precluded the possibility of meta-analysis. However, a review of available data showed evidence of medium to large effects for emotional exhaustion (burnout), work-related stress and common mental health issues. A content analysis of qualitative data of perceived effect complemented quantitative findings.
Conclusion
Global research into the use of art therapy-based methods to address burnout and psychosocial distress in HCWs is growing. Whilst further high-quality evidence such as randomised controlled trials would be beneficial, findings suggest that art therapy-based methods should be strongly considered as an acceptable and effective treatment for symptoms of emotional exhaustion (burnout) and psychosocial distress in HCWs.
Sustainable Hydrodynamic of Artificial Neural Networks and Logistic Regression Model to Lane Change Serious Conflict at Unsignalized Intersection on Malaysia’s Federal Route
Authors: Mustakim Fajaruddin , Aziz Azlan Abdul , Ahmad Mohammad Nazir , Jamian Saifulnizan B. 
Published: March 2023

Abstract
The neural network approach is used to resolve the interdependencies between inputs and outputs in a major conflict on the Malaysian Federal Route’s unsignalized intersection (UI). Two group of dataset being use in this study, they are right turning motor vehicle (RTMs) which consist eight hundred forty five data and serious conflict lane change model, consist three hundred sixty three dataset. The aim of the study are to develop serious conflict lane change model by using artificial neuron network (ANN) and logistic regression method (LRM) and to identify the risk of right turning motor vehicle (RTMs) behaviour. The input data consists traffic behaviour, type of gap, road geometry and traffic facilities. Subsequently the output data will be lane change serious conflict, the study utilize SPSS 26 statistic software. The first section of the study covers the neural network, while the second section describes the strategy utilised to analyse the scientific work.
Third part cover the simple analysis of lane change serious conflict and analysis of gap types. Last part is comparison result between logistic regression method and artificial neuron network. This study reveals that lane change due angular conflict, speed limit 50kph, Gap 3 type, second passenger car, motorcycles, motorcycle stop near passenger car, traffic light and lane width were found significance in lane change serious conflict models. The study has determine that RTMs is motorcycle as vulnerable mode of transport. Besides, this study found that the combination between both method ANN and LRM sustainable hydrodynamic and complement each other especially on explaining the outcomes result.
Multimaterial Fiber is a Physical Simulator of a Capillary Instability
Authors: de Lima Camila Faccini , Wang Fan , Johnson Steven , Gumennik Alexander 
Published: March 2023

Abstract
The capillary breakup of cores is an exclusive approach to fabricating fiber-integrated optoelectronics and photonics. A physical understanding of this fluid-dynamic process is necessary for yielding the desired solid-state fiber-embedded multimaterial architectures by design rather than by exploratory search. We discover that the nonlinearly complex and, at times, even chaotic capillary breakup of multimaterial fiber cores becomes predictable when the fiber is exposed to the spatiotemporal temperature profile, imposing a viscosity modulation comparable to the breakup wavelength. The profile acts as a notch filter, allowing only that single wavelength out of the continuous spectrum to develop predictably, following Euler-Lagrange dynamics. We argue that this understanding not only enables designing the outcomes of the breakup necessary for turning it into a technology for materializing fiber-embedded functional systems but positions a multimaterial fiber as a universal physical simulator of capillary instability in viscous threads.
Error Mitigation Thresholds in Noisy Quantum Circuits
Authors: Niroula Pradeep , Gopalakrishnan Sarang , Gullans Michael 
Published: March 2023

Abstract
Extracting useful information from noisy near-term quantum simulations requires error mitigation strategies. A broad class of these strategies rely on precise characterization of the noise source. We study the performance of such strategies when the noise is imperfectly characterized. We adapt an Imry-Ma argument to predict the existence of an error mitigation threshold for random spatially local circuits in spatial dimensions D ≥ 2: characterization disorder below the threshold rate allows for error mitigation up to times that scale with the number of qubits. For one-dimensional circuits, by contrast, mitigation fails at an O(1) time for any imperfection in the characterization of disorder. We discuss implications for tests of quantum computational advantage, fault-tolerant probes of measurement-induced phase transitions, and quantum algorithms in near-term devices.
Improvements to diagnosis peripheral lung lesions with a hand- drawn bronchial map: a cohort study
Authors: Wu Shengchang , Zhou Hongbin , Duan Ting , Cao Liming , Ni Feihua , Shao Fangchun 
Published: March 2023

Abstract
Peripheral lung lesions (PLLs) have become common findings in routine medical practice. To evaluate whether the hand-drawn bronchial map (HBM) can increase the diagnostic yield of bronchoscope for PLLs. A study on the evaluation of this method for the diagnosis of PPLs was conducted on patients from January 2020 to December 2020 in the Department of Respiratory Medicine, Zhejiang Provincial People’s Hospital. Patients who underwent transbronchial lung biopsy (TBLB) with HBM were included in the HBM group and enrolled into the NHBM group without HBM. A total of 105 patients were included. 71 patients were in the HBM group and 34 patients were in the NHBM group. Overall, 61 (61.62%) of the confirmed lesions were malignant and adenocarcinoma was the main type. 38 (38.38%) lesions were benign. The overall determined diagnostic yield of benign lesions and malignant lesions was no significant difference (P = 0.101). When lesion > 20 mm and ≤ 30 mm, the diagnostic yield in HBM group was significantly higher than that in NHBM group (80.77% vs 45.45%, p=0.032). Compared to the NHBM group, endobronchial ultrasound (EBUS) detection rate in the HBM group had significantly higher diagnostic yield (83.1% vs 58.82%, p=0.007). Multivariate analysis showed that only lesion > 2cm and the bronchial generation of lesion ≤ 5th generation affected diagnostic yield. A hand-drawn bronchial map with high convenience and low cost greatly increases EBUS detection rate and diagnostic yield of bronchoscope for PPLs.
Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome
Authors: Villoslada-Blanco Pablo , Pérez-Matute Patricia , Recio-Fernández Emma , Íñiguez María , Blanco-Navarrete Pilar , Metola Luis , Ibarra Valvanera , Alba Jorge , de Toro María , Oteo José A. 
Published: March 2023

Abstract
Introduction: Oral microbiome is the second largest microbial community in humans after gut. Human immunodeficiency virus (HIV) infection triggers an impairment of the immune system which could favour the growth and the colonization of pathogens in the oral cavity, and this dysbiosis has been associated with oral manifestations that worsen the quality of life of these patients. Antiretroviral therapy (ART) could also drive changes in specific oral bacterial taxa associated with such periodontal diseases. Integrase strand transfer inhibitors (INSTIs), therapy of choice in the treatment of naive HIV-patients, are able to reverse the impact of HIV infection on systemic inflammation, gut permeability and gut bacterial diversity/richness. The objective of this study was to analyse the effects of HIV infection per se and INSTIs on salivary bacteriome composition, taking into consideration other factors such as smoking, that could also have a significant impact on oral microbiome. Methods: To accomplish this objective, 26 non-HIV-infected volunteers and 30 HIV-infected patients (15 naive and 15 under INSTI-regimen) were recruited. Salivary samples were collected to measure lysozyme levels. Oral bacteriome composition was analysed using 16S rRNA gene sequencing. Results: Naive HIV-infected patients showed statistically higher levels of lysozyme compared to controls (p < 0.001) and INSTIs-treated patients (p < 0.05). Our study was unable to detect differences in α nor β-diversity among the three groups analysed, although significant differences in the abundance of some bacterial taxonomical orders were detected. These differences seem to be partially independent of smoking habit. Conclusions: HIV infection and INSTIs effects on oral microbiota seem not to be very potent, probably due to the modulation of other factors such as smoking and the greatest outward exposure of the oral cavity.
ANO7 African-ancestral genomic diversity and advanced prostate cancer
Authors: Hayes Vanessa , Jiang Jue , Soh Pamela , Mutambirwa Shingai , Haiman Christopher , Bornman Riana , Jaratlerdsiri Weerachai 
Published: March 2023

Abstract
BACKGROUND: Prostate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate specific Anoctamin 7 (ANO7) gene linked with poor patient outcomes, has recently been identified as the target for an African-specific protein-truncating PCa risk allele.
METHODS: Here we determined the role of ANO7 in a study of 889 men from southern Africa, leveraging exomic genotyping array PCa case-control data (n=780, 17 ANO7 alleles) and deep sequenced whole genome data for germline and tumour ANO7 interrogation (n=109), while providing clinicopathologically matched European derived sequence data comparative analyses (n=57). Associated predicted deleterious variants (PDVs) were further assessed for impact using computational protein structure analysis.
RESULTS: Notably rare in European patients, we found the common African PDV p.Ile740Leu variant (rs74804606) to be associated with PCa risk in our case-control analysis (Wilcoxon rank-sum test, false discovery rate/FDR=0.03), while sequencing revealed cooccurrence with the recently reported African-specific deleterious risk variant p.Ser914* (rs60985508). Additional findings include, a novel protein truncating African-specific frameshift variant p.Asp789Leu, African-relevant PDVs associated with altered protein structure at Ca2+-binding sites, early-onset PCa associated with PDVs and germline structural variants in Africans (Linear regression models, -6.42 years, 95% CI=-10.68 to -2.16, P-value=0.003) and ANO7 as an inter-chromosomal PCa-related gene fusion partner in African derived tumours.
CONCLUSIONS: Here we provide not only validation for ANO7 as an African-relevant protein-altering PCa risk locus, but additional evidence for a role of inherited and acquired ANO7 variance in the observed phenotypic heterogeneity and African ancestral health disparity.
Prevalence and Clinical characteristics of Molar-Incisor Hypomineralization in Syrian children: A Cross-sectional Study
Authors: Al-Nerabieah Zuhair , AlKhouli Muaaz , Dashash Mayssoon 
Published: March 2023

Abstract
This study was undertaken to determine the prevalence of molar incisor hypomineralization (MIH) in Syrian children and to provide information about clinical patterns and severity of MIH lesions. A sample of 1138 children aged 8–11 years was recruited for this cross-sectional study. The diagnosis of MIH was made using the criteria of the European Academy of Paediatric Dentistry (EAPD) and the MIH/HPSMs short charting form was used to score the index teeth. The results showed that the prevalence of MIH in Syrian children was 39.9%. Demarcated opacities were the most prevalent pattern of MIH defects on Permanent first molars (PFMs) and permanent incisors (PIs). Spearman rank correlation showed that the mean number of PIs and HPSMs with MIH increased when the number of affected PFMs was increased (P < 0.001). Independent t-test resulted that girls showed a higher number of severe PFMs than boys did with a statistically significant difference (t = 1.77, P < 0.05). Moreover, the independent t-test showed that the number of severe PFMs is higher than the number of severe PIs with a statistically significant difference (t = 1.99, P < 0.05). In addition, the mean dmft/DMFT index in children with MIH was found to be significantly higher than children without MIH (P༜0.05). The findings emphasize the need for early identification and management of MIH in children to prevent adverse effects on their oral health.
Clinical and neuroimaging characteristics in mild-type infantile acute subdural hematoma: a report of four cases
Authors: Aoki Nobuhiko 
Published: March 2023

Abstract
Purpose
Infantile acute subdural hematoma (IASDH) has a limited age distribution and mostly benign clinical features. Mild-type IASDH has a stereotypical clinical course that, however, has been described in only a few studies.
Methods
Four male infants (aged 6–10 months; mean age: 7.5 months) were diagnosed with mild-type IASDH associated with retinal hemorrhage (RH) after suffering from occipital impact in a fall. The present case series reviews their clinical features and neuroimaging findings, including CT and MRI findings.
Results
All infants fell backwards from a standing or sitting position onto a soft surface, striking the occipital region. They began crying on impact and then soon afterwards exhibited seizure-like activity or recurrent vomiting. CT and MRI revealed a thin, unclotted subdural hematoma (SDH) without mass effect or brain parenchymal abnormality. Various degrees of bilateral retinal hemorrhage (RH) were observed. On the day of symptom onset, all infants returned to baseline, and follow-up for more than 5 years revealed normal development with no deficits.
Conclusions
Mild-type IASDH with retinal hemorrhage presents with seizure-like activity or recurrent vomiting preceded by crying after an occipital impact on a soft surface. The clinical course of IASDH is followed by rapid recovery on the day of symptom onset. CT and MRI findings reveal a small, unclotted subdural hematoma (SDH) without a mass effect or cerebral parenchymal abnormality.
Gastroblastoma without GLI1 and EWSR1 gene breaks
Authors: Gong Can , Xu Jun yi , Qiao Shu ye , Zhang Xue mei , Yi Min 
Published: March 2023

Abstract
Gastroblastoma (GB),a newly discovered gastric tumor with epithelial and diaphthytal differentiation,was first reported in 2009 by Miettinen et al. So far,a total of 17 cases have been reported in domestic and foreign literature,of which 13 cases were reported in the English literature,4 cases were reported in the Chinese literature,6 of 17 cases had confirmed MALAT1-GLI1 fusion gene;1 case found EWSR1-CTBP1 fusion gene. WHO (2019) included the classification of digestive system tumors for the first time. Because gastroblastoma is very rare and has a bidirectional differentiation in morphology,the differential diagnosis of them with other bidirectional tumors of the stomach (such as synovial sarcoma and sarcomatoid carcinoma) and various gastric tumors characterized by relatively mild epithelioid or spindle cells has become very difficult and easy to misdiagnosis. In this paper,a 19-year-old woman,reviewed the relevant literature,summarized the findings,discussed the clinical characteristics,pathological histology,diagnosis,differential diagnosis,treatment and prognosis,so as to improve clinical and pathological awareness of the disease,and reduce misdiagnosis and mistreatment.
Hepatozoon spp. infection in wild canids in the eastern United States
Authors: Baker Eliza , Jensen Alex , Miller Debra , Garrett Kayla Buck , Cleveland Christopher A. , Brown Justin , Why Kyle , Gerhold Richard 
Published: March 2023

Abstract
Background: Hepatozoon spp. are apicomplexan parasites known to cause musculoskeletal disease in a variety of animals. Two species are known to infect wild and domestic canids in the United States: H. canis and H. americanum.
Methods: In this study, blood, heart, and/or spleen samples were collected from 278 wild canids (180 coyotes, 93 red foxes, and 5 gray foxes) in the eastern United States and tested via PCR for Hepatozoon. Necropsies were performed when whole carcasses were available (n=94), and histology slides of heart and skeletal muscle were assessed for Hepatozoon cysts and associated inflammation.
Results: Hepatozoon spp. were found in 24.2% (59/278) of individuals, with H. canis in 14.0% (34/278) and H. americanum in 10.7% (26/278). One coyote was positive for both H. canis and H. americanum. Foxes were more likely to be positive for H. canis than coyotes (23% and 7% respectively, p=0.0008), while only coyotes were positive for H. americanum. Of the eight sampled states, H. canis was present in six while H. americanum was found in two southern states (South Carolina and Louisiana). Infection status was positively correlated with myositis and myocarditis, and heart or muscle cysts were found in 83% (5/6) of H. americanum-positive coyotes.
Conclusion: This survey showed a moderate prevalence of Hepatozoon spp. in states where the parasite was previously unrecorded including Tennessee, South Carolina, and Pennsylvania.
Comparison of different fibula procedures in tibiotalocalcaneal arthrodesis with a retrograde intramedullary nail: a mid-term retrospective study
Authors: He Wenbao , Zhou Haichao , Li Zhendong , Zhao Youguang , Xia Jiang , Li Yongqi , Chen Cheng , Huang Hui , Zhang Yi , Li Bing , Yang Yunfeng 
Published: March 2023

Abstract
Background: Tibiotalocalcaneal (TTC) arthrodesis with a retrograde intramedullary nail for severe tibiotalar and talocalcaneal arthritis shows a high fusion rate, but no studies focused on how to handle the fibula intraoperatively could achieve better results. The study aims to compare the effects of different fibular procedures.
Methods: We performed a retrospective review of severe tibiotalar and talocalcaneal arthritis in adults treated with TTC arthrodesis by retrograde intramedullary nail between January 2012 and July 2017, totally 58 patients were enrolled in the final analysis with an average age of 53.2 (range 32 to 69) years old, and they were divided into 3 groups according to different fibular procedures: fibular osteotomy (FO, n=21), fibular strut (FS, n=19) and fibular preserving (FP, n=18). Functional outcome and pain were assessed using the American Orthopedic Foot and Ankle Society ankle and hindfoot score (AOFAS) and visual analogue scales (VAS). Operation time, fusion time, radiographic evaluation and complications were also recorded.
Results: The mean postoperative follow-up was 66.0 (range 60 to 78) months. All groups showed a high fusion rate (90.5% for FO, 94.7% for FS, and 94.4% for FP), significant improvement in AOFAS ankle and hindfoot score and VAS score at the latest follow-up. There were no significant differences among the 3 groups for these parameters. The mean operation time of FS (131.3±17.1min) was longer than that of FO (119.3±11.7min) and FS (112.2±12.6min) but the fusion time was shorter (15.1±2.8 weeks for FS, 17.2±1.9 weeks for FO and 16.8±1.9 weeks for FP ). These parameters showed great statistical differences.
Conclusion: Tibiotalocalcaneal arthrodesis by retrograde intramedullary nail is an effective procedure to treat severe tibiotalar and talocalcaneal arthritis in adults, fibular strut can shorten fusion time when compared with fibular osteotomy and fibular preserving.
Nonlinear changes in delayed functional network topology in Alzheimer’s disease: relationship with amyloid and tau pathology
Authors: Mijalkov Mite , Veréb Dániel , Canal-Garcia Anna , Hinault Thomas , Volpe Giovanni , Pereira Joana B. 
Published: March 2023

Abstract
Background
Alzheimer’s disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different brain regions across the Alzheimer’s disease continuum. However, the mechanisms underlying these nonlinear changes remain largely unknown. Here, we address this question using a novel method based on temporal or delayed correlations and calculate new whole-brain functional networks to tackle these mechanisms.
Methods
To assess our method, we evaluated 166 individuals from the ADNI database, including amyloid-beta negative and positive cognitively normal subjects, patients with mild cognitive impairment, and patients with Alzheimer’s disease dementia. We used the clustering coefficient and the global efficiency to measure the functional network topology and assessed their relationship with amyloid and tau pathology measured by positron emission tomography, as well as cognitive performance using tests measuring memory and global cognition.
Results
Our study found nonlinear changes in the global efficiency, but not in the clustering coefficient, showing that the nonlinear changes in functional connectivity are due to an altered ability of brain regions to communicate with each other through direct paths. These changes were most prominent in early disease stages, while later stages of Alzheimer’s disease were associated with more widespread network disruptions characterized by additional clustering changes. Both network measures, i.e., global efficiency and clustering, showed quadratic associations with pathological amyloid and tau burden as well as cognitive decline.
Conclusions
This study suggests that global efficiency is a more sensitive indicator of network changes in Alzheimer’s disease when compared to clustering coefficient. Both network properties were associated with pathology and cognitive performance, demonstrating their relevance in clinical settings. Our findings provide an insight into the mechanisms underlying nonlinear changes in functional network organization in Alzheimer’s disease, suggesting that it is the lack of direct connections what drives these functional changes.