bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational security: conceptualization and operationalization in small-scale, strengths-based, community-embedded youth justice facilities
Authors: Souverein Fleur , Mulder Eva , van Domburgh Lieke , Popma Arne 
Published: August 2023

Abstract
Background
Given the developmental vulnerability of justice-involved youth, providing a safe environment in secure facilities is a paramount, yet challenging task. Within this complexity, a sound security framework is key. The security framework exists on three dimensions: physical, procedural and relational security. Existing knowledge points at the importance of a shift in focus on physical and procedural security towards relational security as the core of the security framework. At the same time there is a dearth of knowledge on relational security, particularly in the context of youth justice. This paper explores relational security and its working mechanisms in practice.

Methods
This paper draws on findings of a comprehensive three-year evaluation of three small-scale, community-embedded facilities that are grounded in relational security. The approach of the evaluation was derived from action research, involving a cyclic process alternating between action, research and critical reflection, while engaging all stakeholders in the research process. The action research cycle involved qualitative research (a total of 63 semi-structured interviews) incorporating the perspective of staff, youth and parents.

Results
Relational security is grounded in three distinct, but interrelated, elements – staff’s basic attitude, a constructive alliance between staff and youth, staff presence – and promotes a safe and therapeutic environment through several mechanisms.

Conclusions
Relational security can be defined in a practical conceptualization; outlining a way of working that guides staff in how to establish a safe and therapeutic environment in secure facilities. This conceptualization finds support in the well-established literature covering the therapeutic alliance and can be substantiated by two aligning theories concerning youth justice strategies: social-ecological theory and self-determination theory. Relational security is not only a way of working, but also a way of being. It encompasses a vision about security and mentality towards justice-involved youth that sees them not merely as ‘risks to be managed’, but primarly as ‘resources to be developed’.
Sustainable eco-friendly ratio-based spectrophotometric and HPTLC-densitometric methods for simultaneous analysis of co-formulated anti-migraine drugs with overlapped spectra
Authors: El-Maraghy Christine Maged 
Published: August 2023

AbstractConsidering the green chemistry perspective and improving the environmental impact of quality control labs; two direct techniques with less hazardous solvents, less waste production and less energy consumption were developed for simultaneous analysis of Aspirin and Metoclopramide in bulk powder and pharmaceutical formulation. The ratio between the two drugs in their co-formulated preparation is very challenging; (90: 1, Aspirin: Metoclopramide). The first technique is spectrophotometry using simple mathematical operations; ratio difference and derivative ratio–zero crossing. The second technique is high-performance thin-layer chromatography (HPTLC) -densitometry which used a mobile phase consisting of cyclo-hexane: methanol: methylene chloride in a ratio of (1:4:1, v/v/v). The greenest solvents which give acceptable resolution were chosen. Following the International Conference on Harmonization (ICH) guidelines, the methods were found to be accurate, precise, and selective. Those methods were statistically compared to the reported spectrophotometric method and the results proved that there is no significant difference in accuracy and precision. Furthermore, the developed methods were assessed using the Analytical Eco-scale, Green Analytical Procedure Index (GAPI) and the Analytical Greenness calculator (AGREE), which gave a full image about their greenness profile. The spectrophotometry was found to be an excellent green technique compared to HPTLC with was considered an acceptable green one. The developed HPTLC-densitometric method was used for the first time for the analysis of this binary mixture. The two proposed spectrophotometric methos have advantages over the published methods as they used easy manipulation steps and are applied on the market pharmaceutical formulation. Owing to the advantages of the developed techniques; being green, do not require expensive sophisticated equipment or large volume of solvents; they could be used for routine analysis in quality control aspects.
NG2-positive pericytes regulate homeostatic maintenance of slow-type skeletal muscle with rapid myonuclear turnover
Authors: Tatsukawa Takamitsu , Kano Kohei , Nakajima Kei-ichi , Yazawa Takashi , Eguchi Ryoji , Kabara Maki , Horiuchi Kiwamu , Hayasaka Taiki , Matsuo Risa , Hasebe Naoyuki , Azuma Nobuyoshi , Kawabe Jun-ichi 
Published: August 2023

Abstract
Background
Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady conditions with the sporadic fusion of newly produced myocytes to compensate for the muscular turnover caused by daily wear and tear. It is becoming clear that microvascular pericytes (PCs) exhibit myogenic activity. However, whether PCs act as myogenic stem cells for the homeostatic maintenance of skeletal muscles during adulthood remains uncertain.

Methods
We utilized PC-fused myofibers using PC-specific lineage tracing mouse (NG2-CreERT/Rosa-tdTomato) to observe whether muscle resident PCs have myogenic potential during daily life. Genetic PC deletion mouse model (NG2-CreERT/DTA) was used to test whether PC differentiates to myofibers for maintenance of muscle structure and function under homeostatic condition.

Results
Under steady breeding conditions, tdTomato-expressing PCs were infused into myofibers, and subsequently, PC-derived nuclei were incorporated into myofibers. Especially in type-I slow-type myofibers such as the soleus, tdTomato+ myofibers were already observed 3 days after PC labeling; their ratio reached a peak (approximately 80%) within 1 month and was maintained for more than 1 year. Consistently, the NG2+ PC-specific deletion induced muscular atrophy in a slow-type myofiber-specific manner under steady breeding conditions. The number of myonucleus per volume of each myofiber was constant during observation period.

Conclusions
These findings demonstrate that the turnover of myonuclei in slow-type myofibers is relatively fast, with PCs acting as myogenic stem cells—the suppliers of new myonuclei under steady conditions—and play a vital role in the homeostatic maintenance of slow-type muscles.
Next-generation sequencing analysis of the molecular spectrum of thalassemia in Southern Jiangxi, China
Authors: Yang Tong , Luo Xuemei , Liu Yanqiu , Lin Min , Zhao Qinfei , Zhang Wenqian , Chen Zhigang , Dong Minghua , Wang Junli , Wang Qi , Zhang Xiaokang , Zhong Tianyu 
Published: August 2023

Abstract
Background
Thalassemia is an extremely prevalent monogenic inherited blood disorder in southern China. It is important to comprehensively understand the molecular spectrum of thalassemia in an area with such a high prevalence of thalassemia before taking appropriate actions for the prevention and treatment of this disorder. Herein, we explored the clinical feasibility of using next-generation sequencing (NGS) for large-scale population screening to illustrate the prevalence and spectrum of thalassemia in Southern Jiangxi.

Methods
Blood samples collected from 136,312 residents of reproductive age in Southern Jiangxi were characterized for thalassemia by NGS. A retrospective analysis was then conducted on blood samples determined to be positive for thalassemia.

Results
In total, 19,827 (14.545%) subjects were diagnosed as thalassemia carriers, and the thalassemia prevalence rate significantly varied by geographical region (p < 0.001). A total of 40 α-thalassemia genotypes including 21 rare genotypes were identified, with -@-SEA/αα being the most prevalent genotype. 42 β-thalassemia genotypes including 27 rare genotypes were identified, with the most common mutation IVS II-654 C > T accounting for 35.257% of these β-thalassemia genotypes. Furthermore, 74 genotypes were identified among 608 individuals with combined α- and β-thalassemia. Notably, most individuals with rare thalassemia mutations had mildly abnormal hematologic parameters including microcytic hypochromia.

Conclusions
Our findings demonstrate the great heterogeneity and diverse spectrum of thalassemia in Southern Jiangxi, emphasizing the importance and necessity of persistent prevention and control of thalassemia in this region. Additionally, our findings further suggest that NGS can effectively identify rare mutations and reduce the misdiagnosis rate of thalassemia.
Rainfall influence and risk analysis on the mural deterioration of Dunhuang Mogao Grottoes, China
Authors: Liu Hongli , Zhang Qiang , Zhang Zhengmo , Guo Qinglin , Lin Wangbin , Gao Wenqiang 
Published: August 2023

Abstract
The Dunhuang Mogao Grottoes are a significant cultural heritage site in the Silk Road, famous for its wonderful murals and statues. The rainfall causes the changes of humidity in the caves, which can easily activate the salts diseases of murals. In order to prevent the deterioration of the murals, the environmental monitoring tests were conducted to analyze the microclimate changes of the cave in rainfall weather, and proposed the risk prevention measures and suggestions. The results indicate that the temperature of caves has small change, but the humidity shows a clear trend of increase. The humidity and the duration of high humidity increases with the increase of the rainfall grade and frequency. The optimal starting time for environment control in the cave is when a

atm
and a

cave
are consistent, and the relative humidity is controlled below 62%. The caves with lower layer, larger degree of openness and small volume are most vulnerable to water vapour diffusion. The environment monitoring should pay more attention to the continuous rainfall weather and the vulnerable caves. The research has great significance for the prevention of ancient mural deterioration.
Propofol infusion syndrome as a cause for CRRT circuit malfunction: a case report with literature review
Authors: Zambon Marjorie Gosdal , Bonfim Luana Caroline Miantti Ghellere , Guerini Isadora Schwaab , de Almeida Lopes Marcela 
Published: August 2023

AbstractBackgroundPropofol is commonly used for sedation in the Intensive Care Unit (ICU). When administered in high doses and for a prolonged time, it can cause a rare but hazardous complication: Propofol Infusion Syndrome (PRIS). Along with other findings, PRIS can cause lipemia and clotting of the Continuous Renal Replacement Therapy (CRRT) circuit.Case presentationA 62-year-old woman admitted to the ICU after an acute ischemic stroke was sedated with Propofol for neuroprotection. On the sixteenth day of infusion (mean daily dose: 4 mg/kg/h), she presented with hyperlactatemia (7.7 mg/dL), acute kidney injury, metabolic acidosis (pH: 7.23 / HCO3–: 12.2 mEq/L), hyperkalemia (6.9 mEq/L), and hypotension requiring high doses of norepinephrine. CRRT and corticosteroids were initiated. After 15 min of CRRT, the blood in the circuit had a milky color, and the therapy was interrupted because of high transmembrane pressure, despite adequate anticoagulation with heparin. Laboratory tests showed hypertriglyceridemia (782 mg/dL), increased transaminases, and creatine phosphokinase (5008 U/L), suggesting the rare and fatal PRIS.ConclusionThere is no established guideline for treating PRIS other than early discontinuation of Propofol and supportive care. Although CRRT is an important tool in managing PRIS, hypertriglyceridemia can cause circuit malfunction. Clinical hypervigilance and serial monitoring in at-risk patients are advised to minimize potentially lethal complications.
Modified Friedmann equations from fractional entropy
Authors: Çoker Zeynep , Ökcü Özgür , Aydiner Ekrem 
Published: August 2023

Abstract
Based on the fractional black-hole entropy (Jalalzadeh S. et al., Eur. Phys. J. C, 81 (2021) 632), we derive the modified Friedmann equations from two different frameworks. First, we consider the modifications of Friedmann equations from the first law of thermodynamics at the apparent horizon. We show that the generalized second law (GSL) of thermodynamics always holds in a region bounded by the apparent horizon. Then, we obtain Friedmann equations from Verlinde's entropic gravity framework. We also compute the fractional corrections to the deceleration parameter q in the flat case k = 0 for both frameworks. Furthermore, we consider the time to reach the initial singularity for the two frameworks. The results indicate that the initial singularity is accessible for both frameworks. However, fractional effects may provide a constraint on the equation-of-state parameter in the entropic gravity scenario since the time is imaginary for

.
Clinical Evaluation of the Sleepy and Sleepless Patient
Authors: Taylor Samuel A. 
Published: August 2023

ABSTRACT

OBJECTIVE
This article addresses the approach to the evaluation of patients who present to a neurologist with excessive daytime sleepiness or difficulty sleeping.

LATEST DEVELOPMENTS
Greater emphasis on the importance of sleep reflects the growing scientific understanding that sleep is critical to overall health and well-being. Consumer sleep technologies, which measure parameters related to sleep, may provide insight into an individual’s sleep-related symptoms and tendencies and have a role in patient-centered sleep evaluation when used within an appropriate clinical context.

ESSENTIAL POINTS
A thorough review of a patient’s history and physical examination findings are important components of the assessment and management of their sleep-related symptoms. An understanding of how the clinical context relates to the categorization of sleep disorders can impact a patient’s symptoms, comorbid neurologic disorders, and overall well-being. Many neurologic conditions are strongly associated with sleep disturbance, risk factors for the development of a sleep disorder, or both. Therefore, it is critical for neurologists to be familiar and comfortable with taking a focused sleep history. Modalities such as in-laboratory polysomnography, home sleep apnea testing, multiple sleep latency testing, and actigraphy, as well as contextualized and prudent use of data obtained from consumer sleep technologies, can be helpful in appropriately selected patients. Mindful integration of these objective data facilitates the diagnosis and management of sleep disorders.
Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice
Authors: Matrongolo Matt J. , Ho-Nguyen Khue-Tu , Jain Manav , Ang Phillip S. , Reddy Akash , Schaper Samantha , Tischfield Max A. 
Published: August 2023

ABSTRACT
Secondary lissencephaly evolved in mice due to effects on neurogenesis and the tangential distribution of neurons. Signaling pathways that help maintain lissencephaly are still poorly understood. We show that inactivating Twist1 in the primitive meninges causes cortical folding in mice. Cell proliferation in the meninges is reduced, causing loss of arachnoid fibroblasts that express Raldh2, an enzyme required for retinoic acid synthesis. Regionalized loss of Raldh2 in the dorsolateral meninges is first detected when folding begins. The ventricular zone expands and the forebrain lengthens at this time due to expansion of apical radial glia. As the cortex expands, regionalized differences in the levels of neurogenesis are coupled with changes to the tangential distribution of neurons. Consequentially, cortical growth at and adjacent to the midline accelerates with respect to more dorsolateral regions, resulting in cortical buckling and folding. Maternal retinoic acid supplementation suppresses cortical folding by normalizing forebrain length, neurogenesis and the tangential distribution of neurons. These results suggest that Twist1 and balanced retinoic acid signaling from the meninges are required to maintain normal levels of neurogenesis and lissencephaly in mice.
The loop-tail mouse model displays open and closed caudal neural tube defects
Authors: Fernández-Santos Beatriz , Reyes-Corral Marta , Caro-Vega José Manuel , Lao-Pérez Miguel , Vallejo-Grijalba Claudia , Mesa-Cruz Cristina , Morón Francisco J. , Ybot-González Patricia 
Published: August 2023

ABSTRACT
Neural tube defects (NTDs) are the second most common cause of congenital malformations and are often studied in animal models. Loop-tail (Lp) mice carry a mutation in the Vangl2 gene, a member of the Wnt-planar cell polarity pathway. In Vangl2+/Lp embryos, the mutation induces a failure in the completion of caudal neural tube closure, but only a small percentage of embryos develop open spina bifida. Here, we show that the majority of Vangl2+/Lp embryos developed caudal closed NTDs and presented cellular aggregates that may facilitate the sealing of these defects. The cellular aggregates expressed neural crest cell markers and, using these as a readout, we describe a systematic method to assess the severity of the neural tube dorsal fusion failure. We observed that this defect worsened in combination with other NTD mutants, Daam1 and Grhl3. Besides, we found that in Vangl2+/Lp embryos, these NTDs were resistant to maternal folic acid and inositol supplementation. Loop-tail mice provide a useful model for research on the molecular interactions involved in the development of open and closed NTDs and for the design of prevention strategies for these diseases.
Temperature and pressure dependency of oxygen consumption during long-term sustained swimming of European eels
Authors: Pohlmann Jan-Dag , Pelster Bernd , Wysujack Klaus , Marohn Lasse , Freese Marko , Lindemann Constantin , Hanel Reinhold 
Published: August 2023

ABSTRACT
Many aspects of the typically 5000–10,000 km spawning migration of the European eel (Anguilla anguilla) remain unknown. As part of this migration, eels undertake extensive diurnal vertical migrations to depths below 1000 m, being exposed to a wide range of temperatures and hydrostatic pressures. In this experimental study, we exposed eels to different combinations of temperature (12–20°C) and pressure (100--800 kPa) during long-term sustained swimming (32–47 days). Both temperature and pressure affected oxygen consumption rate, such that there was a significant increase of metabolic rate with temperature, whereas pressure reduced oxygen consumption, albeit only at higher temperatures. Average oxygen consumption rates ranged between 15 mg kg−1 h−1 (12°C, 100 kPa) and 30.2 mg kg−1 h−1 (20°C, 100 kPa), highlighting the remarkably high swimming efficiency of this species and, more importantly, indicating that past evaluations of the cost of transport are potentially overestimates as they are often based on experiments conducted at atmospheric pressure at higher temperatures.
Genes and Sales
Authors: Gong Shiyang , Li Qian , Su Song , Zhang Juanjuan 
Published: August 2023

This paper presents one of the first marketing applications of molecular genetics. We report evidence that salespeople’s genetic variants linked to educational attainment predict sales performance. Both genetics and selling effort contribute to sales performance, whereas genetics contribute more than personality traits. We further show that adaptive learning, as captured in salespeople’s customer orientation and opportunity recognition skills, may explain the gene-sales relationship. We discuss the implications of these findings for sales management and the value of genetic research for the marketing field. This paper was accepted by Matthew Shum, marketing. Funding: S. Gong acknowledges financial support from the NSFC [Grant 71972040] and Fundamental Research Funds for the Central Universities [2022NTSS43]. Q. Li acknowledges financial support from the NSFC [Grant 72072014] and Young Talent Program of Beijing Foreign Studies University. S. Su acknowledges financial support from the NSFC [Grant 71872016]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4879 .
How habitat factors affect an Aedes mosquitoes driven outbreak at temperate latitudes: The case of the Chikungunya virus in Italy
Authors: Solimini Angelo , Virgillito Chiara , Manica Mattia , Poletti Piero , Guzzetta Giorgio , Marini Giovanni , Rosà Roberto , Filipponi Federico , Scognamiglio Paola , Vairo Francesco , Caputo Beniamino 
Published: August 2023

Background
Outbreaks of Aedes-borne diseases in temperate areas are not frequent, and limited in number of cases. We investigate the associations between habitat factors and temperature on individuals’ risk of chikungunya (CHIKV) in a non-endemic area by spatially analyzing the data from the 2017 Italian outbreak.

Methodology/Principal findings
We adopted a case-control study design to analyze the association between land-cover variables, temperature, and human population density with CHIKV cases. The observational unit was the area, at different scales, surrounding the residence of each CHIKV notified case. The statistical analysis was conducted considering the whole dataset and separately for the resort town of Anzio and the metropolitan city of Rome, which were the two main foci of the outbreak. In Rome, a higher probability for the occurrence of CHIKV cases is associated with lower temperature (OR = 0.72; 95% CI: 0.61–0.85) and with cells with higher vegetation coverage and human population density (OR = 1.03; 95% CI: 1.00–1.05). In Anzio, CHIKV case occurrence was positively associated with human population density (OR = 1.03; 95% CI: 1.00–1.06) but not with habitat factors or temperature.

Conclusion/Significance
Using temperature, human population density and vegetation coverage data as drives for CHIKV transmission, our estimates could be instrumental in assessing spatial heterogeneity in the risk of experiencing arboviral diseases in non-endemic temperate areas.