bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCHOLARLY COMUNICATION MELALUI REPOSITORY INSTITUSI DI PERPUSTAKAAN STIKES INSAN CENDEKIA MEDIKA JOMBANG
Authors: Nuriana Dwi 
Published: August 2023

Tujuan dari penyusunan karya ilmiah ini adalah untuk mengetahui tingkat pengetahuan dan kesadaran yang tinggi dari pola komunikasi ilmiah publikasi karya ilmiah, melalui repository diharapkan keaslian komunikasi ilmiah sebuah karya dapat diketahui dan di pertanggung jawabkan. Metode : dalam paper ini metode diskriptif dengan kajian pustaka berdasarkan data informasi primer dan sekunder serta analisa obyek pada perpustakaan Hasil : adanya publikaasi sangat memotivasi dan mengispirasi dosen untuk menulis karya ilmiah dan penelitian hal ini dapat dilihat dari minat dosen untuk publikasi artikel dalam OJS dan repository dan meningkatnya perolehan hibah penelitian dosen di STIKES Insan Cendekia Mdika Jombang Pembahasan : Perpustakaan STIKES Insan Cendekia Medika Jombang mengembangkan repositori institusi sebagai saranan memanajemen koleksi hasil karya sivitas akademika dalam bentuk digital baik LTA, Skripsi maupun karya penelitian dosen agar dapat disebarluaskan ke masyarakat luas dan secara tidak langsung karya intelektulal sivitas akademik dipublikasikan secara online dan dapat di manfaatkan oleh masyarakat pengguna informasi perpustakaan. Dosen dan mahasiwa diwajibkan untuk mengunggah semua karya dalam repositori institusi dengan kebijakan serah simpan karya sivitas akademika ini mampu memberikan motivasi dan semangat baru bagi dosen dan mahasiswa untuk menjadi peneliti dan penulis ketika karya ilmiah di sitasi oleh penulis lain ada . Peran pustakawan sangat penting sebagai mitra dosen dan mahasiswa dalam memberikan bimbingan literasi penulisan artikel ilmiah sehingga karya ilmiah dosen dan mahasiwa lebih berkualitas baik dari etika penulisanya maupun sitasi menggunakan referensi yang up date Kesimpulan : budaya akademis dalam forum komunikasi ilmiah, scholarly communication dalam rangka publikasi artikel ilmiah di repository Perpustakaan STIKes Insan Cendekia medika Jombang diharapkan akan dapat melahirkan generasi intelektual yang mahir menulis dengan etika penulisan yang baik dan benar. Peneliti, Dosen diharapkan dapat memenuhi Tri Dharma Perguruan tinggi dengan melakukan penelitian secara konsisten dan menjadi tauladan bagi mahasiswa dalam menulis karya ilmiah. Peran pustakawan embedded librarian sangat penting dalam mengawal perkembangan repository dan komunikasi ilmiah di perpustakaan Sedangkan bagi mahasiswa diharapkan tidak hanya sekedar mampu menulis karya ilmiah dengan mengkaji informasi, memotivasi dan mengispirasi untuk memformulasikan gagasan berbentuk tulisan dengan referensi yang up date memanfaatkan journal baik ilmiah nasional maupun internasional. Rekomendaasi: diharapkan dengan kebijakan publikasi karya sivitas akademika akan mampu melahirkan generasi penulis muda yang berbakat dan kompeten dalam bidangnya, sehingga kita bisa membantu pemerintah mengejar ketertinggalan dalam hal publikasi di tingkat internasional.
INOVASI DAN PRAKTIK TERBAIK PERPUSTAKAAN PERUM LKBN ANTARA:MENDUKUNG TUJUAN STRATEGIS PERUSAHAAN
Authors: Sulistyorini Dyah , Sunarto Agus 
Published: August 2023

Perum LKBN Antara’s library once only a small unit that manage news documentation produce by Antara (in the year of 1950), then transform into special library which manage the multimedia databases. Innovation and all the best practices in library must be accordance with corporate strategic policy. Innovation is beneficial to improve product, improve process or effectiveness to create modern values for the stakeholders. The Antara Library is a special library that manages and provides information and documentation services. The purpose of this study is to record Antara’s library innovation and best practices. Method used is qualitative with descriptive study. The best practices are information repackaging and the implementation of knowledge management: 1) packaging the old databases into website antaranews.com/tag/100/antara-doeloe 2) e-book’s kaleidoscope 3) media monitoring 4) research for books and news content 5) activities that support the implementation of knowledge management. Those best practices are measured by key performance indicators and being reviewed adjusted by corporate strategic goal. The innovation closely related with performance, innovation will make radical change or breakthrough to improve performance. Antara’s library innovations are: technology, manufacturing, business, organization behavior, human values and design & interactivity.
Unraveling the transcriptome-based network of tfh cells in primary sjogren syndrome: insights from a systems biology approach
Authors: Luo Danyang , Li Lei , Yang Yi , Ye Yulin , Hu Jiawei , Zong Yuan , Zhao Jiawen , Gao Yiming , Xu Haimin , Li Ning , Xie Yinyin , Jiang Liting 
Published: August 2023

BackgroundPrimary Sjogren Syndrome (pSS) is an autoimmune disease characterized by immune cell infiltration. While the presence of follicular T helper (Tfh) cells in the glandular microenvironment has been observed, their biological functions and clinical significance remain poorly understood.MethodsWe enrolled a total of 106 patients with pSS and 46 patients without pSS for this study. Clinical data and labial salivary gland (LSG) biopsies were collected from all participants. Histological staining was performed to assess the distribution of Tfh cells and B cells. Transcriptome analysis using RNA-sequencing (RNA-seq) was conducted on 56 patients with pSS and 26 patients without pSS to uncover the underlying molecular mechanisms of Tfh cells. To categorize patients, we employed the single-sample gene set enrichment analysis (ssGSEA) algorithm, dividing them into low- and high-Tfh groups. We then utilized gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and deconvolution tools to explore functional and immune infiltration differences between the low- and high-Tfh groups.ResultsPatients with pSS had a higher positive rate of the antinuclear antibody (ANA), anti-Ro52, anti-SSA, anti-SSB and hypergammaglobulinaemia and higher levels of serum IgG compared to the non-pSS. Histopathologic analyses revealed the presence of Tfh cells (CD4+CXCR5+ICOS+) in germinal centers (GC) within the labial glands of pSS patients. GSEA, WGCNA, and correlation analysis indicated that the high-Tfh group was associated with an immune response related to virus-mediated IFN response and metabolic processes, primarily characterized by hypoxia, elevated glycolysis, and oxidative phosphorylation levels. In pSS, most immune cell types exhibited significantly higher infiltration levels in the high-Tfh group compared to the low-Tfh group. Additionally, patients in the Tfh-high group demonstrated a higher positive rate of the ANA, rheumatoid factor (RF), and hypergammaglobulinaemia, as well as higher serum IgG levels.ConclusionOur study suggests that Tfh cells may play a crucial role in the pathogenesis of pSS and could serve as potential therapeutic targets in pSS patients.
Evaluation of an automated microscope using machine learning for the detection of malaria in travelers returned to the UK
Authors: Rees-Channer Roxanne R. , Bachman Christine M. , Grignard Lynn , Gatton Michelle L. , Burkot Stephen , Horning Matthew P. , Delahunt Charles B. , Hu Liming , Mehanian Courosh , Thompson Clay M. , Woods Katherine , Lansdell Paul , Shah Sonal , Chiodini Peter L. 
Published: August 2023

IntroductionLight microscopy remains a standard method for detection of malaria parasites in clinical cases but training to expert level requires considerable time. Moreover, excessive workflow causes fatigue and can impact performance. An automated microscopy tool could aid in clinics with limited access to highly skilled microscopists, where case numbers are excessive, or in multi-site studies where consistency is essential. The EasyScan GO is an automated scanning microscope combined with machine learning software designed to detect malaria parasites in field-prepared Giemsa-stained blood films. This study evaluates the ability of the EasyScan GO to detect, quantify and identify the species of parasite present in blood films compared with expert light microscopy.MethodsTravelers returning to the UK and testing positive for malaria were screened for eligibility and enrolled. Blood samples from enrolled participants were used to make Giemsa-stained smears assessed by expert light microscopy and the EasyScan GO to determine parasite density and species. Blood samples were also assessed by PCR to confirm parasite density and species present and resolve discrepancy between manual microscopy and the EasyScan GO.ResultsWhen compared to light microscopy, the EasyScan GO exhibited a sensitivity of 88% (95% CI: 80-93%) and a specificity of 89% (95% CI: 87-91%). Of the 99 samples labelled positive by both, manual microscopy identified 87 as Plasmodium falciparum (Pf) and 12 as non-Pf. The EasyScan GO correctly reported Pf for 86 of the 87 Pf samples and non-Pf for 11 of 12 non-Pf samples. However, it failed to distinguish between non-Pf species, reporting all as P. vivax. The EasyScan GO calculated parasite densities were within +/-25% of light microscopy densities for 33% of samples between 200 and 2000 p/µL, falling short of WHO level 1 (expert) manual microscopy competency (50% of samples should be within +/-25% of the true parasitemia).DiscussionThis study shows that the EasyScan GO can be proficient in detecting malaria parasites in Giemsa-stained blood films relative to expert light microscopy and accurately distinguish between Pf and non-Pf species. Performance at low parasite densities, distinguishing between non-Pf species and accurate quantitation of parasitemia require further development and evaluation.
A single infusion of intravenous lidocaine for primary headaches and trigeminal neuralgia: a retrospective analysis
Authors: Mullins C. F. , Fuccaro M. , Pang D. , Min L. , Andreou A. P. , Lambru G. 
Published: August 2023

IntroductionIntravenous (IV) lidocaine has been used as a transitional treatment in headache and facial pain conditions, typically as an inpatient infusion over several days, which is costly and may increase the risk of adverse effects. Here we report on our experience using a single one-hour IV lidocaine infusion in an outpatient day-case setting for the management of refractory primary headache disorders with facial pain and trigeminal neuralgia.MethodsThis is a retrospective, single-center analysis on patients with medically refractory headache with facial pain and trigeminal neuralgia who were treated with IV lidocaine between March 2018 and July 2022. Lidocaine 5 mg.kg−1 in 60 mL saline was administered over 1 h, followed by an observation period of 30 min. Patients were considered responders if they reported reduction in pain intensity and/or headache frequency of 50% or greater. Duration of response was defined as short-term (&lt; 2 weeks), medium-term (2–4 weeks) and long-term (&gt; 4 weeks).ResultsForty infusions were administered to 15 patients with trigeminal autonomic cephalalgias (n = 9), chronic migraine (n = 3) and trigeminal neuralgia (n = 3). Twelve patients were considered responders (80%), eight of whom were complete responders (100% pain freedom). The average duration of the treatment effect for each participant was 9.5 weeks (range 1–22 weeks). Six out of 15 patients reported mild and self-limiting side effects (40%).ConclusionA single infusion of IV lidocaine might be an effective and safe transitional treatment in refractory headache conditions with facial pain and trigeminal neuralgia. The sustained effect of repeated treatment cycles in some patients may suggest a role as long-term preventive therapy in some patients.
Vascular risk factors for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis
Authors: Cai Hanlin , Yang Feng , Gao Hui , Huang Keru , Qin Linyuan , Wang Ruihan , Liu Yi , Zhou Liangxue , Hao Zilong , Zhou Dong , Chen Qin 
Published: August 2023

ObjectiveIdiopathic normal-pressure hydrocephalus (iNPH) is a treatable cause of dementia; however, its etiology and pathogenesis remain poorly understood. The objective of this study was to investigate the prevalence and impact of vascular risk factors in patients with iNPH compared to a control cohort to better understand the potential mechanisms and preventive measures.MethodsWe systematically searched PubMed, Web of Science, Embase, and the Cochrane Library (from inception to December 20, 2022) for studies reporting vascular risk factors for the development of iNPH. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects models.ResultsAfter screening 1,462 articles, 11 case-control studies comprising 1,048 patients with iNPH and 79,668 cognitively unimpaired controls were included in the meta-analysis. Our data showed that hypertension (N = 991, OR = 2.30, 95% CI 1.64 to 3.23, I2= 64.0%), diabetes mellitus (DM) (N = 985, OR = 3.12, 95% CI 2.29 to 4.27, I2= 44.0%), coronary heart disease (CHD; N = 880, OR = 2.34, 95% CI 1.33 to 4.12, I2= 83.1%), and peripheral vascular disease (N = 172, OR = 2.77, 95% CI 1.50 to 5.13, I2= 0.0%) increased the risk for iNPH, while overweight was a possible factor (N = 225, OR = 2.01, 95% CI 1.34 to 3.04, I2= 0.0%) based on the sensitivity analysis. Smoking and alcohol consumption were not associated with iNPH.ConclusionsOur study suggested that hypertension, DM, CHD, peripheral vascular disease, and overweight were associated with iNPH. These factors might be involved in the pathophysiological mechanisms promoting iNPH. These findings require further investigation in future studies.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42022383004.
Bilateral globus pallidus interna deep brain stimulation in the treatment of mixed cerebral palsy in ataxia with dyskinesia: a case report
Authors: Chang Lei , Luo Bei , Dong Wenwen , Qiu Chang , Lu Yue , Sun Jian , Yan Jiuqi , Zhang Wenbin , Yan Jun 
Published: August 2023

BackgroundCerebral palsy (CP), a complex syndrome with multiple etiologies, is characterized by a range of movement disorders within the hypokinetic and hyperkinetic spectrum (dystonia or choreoathetosis). CP is often accompanied by neurological and psychiatric signs, such as spasticity, ataxia, and cognitive disorders. Although current treatment options for CP include pharmacological interventions, rehabilitation programs, and spasticity relief surgery, their effectiveness remains limited. Deep brain stimulation (DBS) has demonstrated significant effectiveness in managing dyskinesia; however, its potential therapeutic effect on CP remains determined.MethodsWe present a case of a 44-year-old Asian female who was born as a twin with neonatal ischemic–hypoxic encephalopathy due to prolonged labor and delivery. She was diagnosed with CP at the age of 1 year. The patient exhibited delayed development compared to her peers and presented with various symptoms, including slurred speech, broad-based gait, horseshoe inversion of the right lower extremity, involuntary shaking of the upper extremities bilaterally, and hypotonia and showed no improvement with levodopa therapy. Two years ago, she developed progressive head tremors, which worsened during periods of tension and improved during sleep. As medical treatments proved ineffective and there were no contraindications to surgery, we performed bilateral globus pallidus interna DBS (GPi-DBS) to alleviate her motor dysfunction.ResultsFollowing a 6-month follow-up, the patient demonstrated significant improvements in motor symptoms, including head and limb tremors and dystonia. In addition, significant improvement was observed in her overall psychological well-being, as evidenced by reduced anxiety and depression levels.ConclusionDBS is an effective treatment for dyskinesia symptoms associated with CP in adults. Moreover, its effectiveness may continue to increase over time.
ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension
Authors: Oliveira Aline C. , Karas Marianthi M. , Alves Matthew , He Jacky , de Kloet Annette D. , Krause Eric G. , Richards Elaine M. , Bryant Andrew J. , Raizada Mohan K. 
Published: August 2023

BackgroundPulmonary hypertension (PH), characterized by elevated pulmonary pressure and right heart failure, is a systemic disease involving inappropriate sympathetic activation and an impaired gut-brain-lung axis. Global overexpression of angiotensin converting enzyme 2 (ACE2), a cardiopulmonary protective enzyme of the renin-angiotensin system, attenuates PH induced by chronic hypoxia. Neurons within the paraventricular nucleus of the hypothalamus (PVN) that synthesize corticotropin-releasing hormone (CRH) are activated by stressors, like hypoxia, and this activation augments sympathetic outflow to cardiovascular tissues. These data coupled with our observations that ACE2 overexpression in CRH cells (CRH-ACE2KI mice) decreases anxiety-like behavior via suppression of hypothalamic–pituitary–adrenal (HPA) axis activity by decreasing CRH synthesis, led us to hypothesize that selective ACE2 overexpression in CRH neurons would protect against hypoxia-induced PH.MethodsCRH-ACE2KI and WT male and female mice were exposed to chronic hypoxia (10%O2) or normoxia (21%O2) for 4 weeks in a ventilated chamber with continuous monitoring of oxygen and carbon dioxide concentrations (n = 7–10/group). Pulmonary hemodynamics were measured with Millar pressure catheters then tissues were collected for histological analyses.ResultsChronic hypoxia induced a significant increase (36.4%) in right ventricular (RV) systolic pressure (RVSP) in WT mice, which was not observed in CRH-ACE2KI mice. No significant differences in RVSP were observed between male and female mice in any of the groups.ConclusionOverexpression of ACE2 in CRH cells was protective against hypoxia-induced PH. Since the majority of expression of CRH is in brain nuclei such as paraventricular nucleus of the hypothalamus (PVN) and/or central nucleus of the amygdala (CeA) these data indicate that the protective effects of ACE2 are, at least in part, centrally mediated. This contributes to the systemic nature of PH disease and that CRH neurons may play an important role in PH.
Food exchange list based on macronutrients: adapted for the Ecuadorian population
Authors: Chisaguano-Tonato Aida Maribel , Herrera-Fontana María Elisa , Vayas-Rodriguez Gabriela 
Published: August 2023

BackgroundFood exchange lists allow health professionals to generate healthy eating plans adapted to individual or population needs. The objective of this study was to develop the first food exchange list based on the macronutrients and energy provided by the various food groups of the Ecuadorian diet.MethodsThe list of Ecuadorian food exchanges was constructed by going through the following phases: (1) Selection of household measurements; (2) Selection of tables and databases of the nutritional composition of food items; (3) Definition of food groups and quantities; (4) Determination of the average energy and macronutrient values of each group; and (5) Photographic record. For the definition of food quantities, statistical criteria were applied according to a standard deviation of ±2SD; thus, for carbohydrates: ±5 g, total fat: ±2 g, and protein: ±3 g. To ensure the inclusion of the food items in the groups, a coefficient of variation of less than 30% and a Z value of ±2 were also considered.ResultsThe list of food exchanges is presented with eight general groups according to the predominant nutrient (carbohydrates, proteins, or fats), and, where necessary, subgroups are included according to the second predominant nutrient. The list includes 404 food items with their photographic record, represented by their net weights and corresponding household measurement. All food items met the statistical criteria that help to reduce the variability of the nutritional composition of the food items in each group.ConclusionThis is the first list of Ecuadorian food exchanges based on statistical criteria. It represents a novel tool for public health professionals as well as researchers. Resulting healthier eating plans may improve daily dietetic practice, facilitate better clinical trial designs and help establish guidelines according to Ecuador’s cultural and dietary patterns. The described methodology can further be used to develop other food exchanges lists for patients with specific nutritional requirements.
A scientometric analysis of research trends on targeting mTOR in breast cancer from 2012 to 2022
Authors: Zhang Xizhou , Wu Jinyao , Yang Qiuping , Tian Huiting , Chen Lingzhi , Zheng Daitian , Ji Zeqi , Cai Jiehui , Chen Yexi , Li Zhiyang 
Published: August 2023

Over the past decade, thousands of articles have been published on the mechanistic target of rapamycin (mTOR) and its role in breast cancer. However, the variability and heterogeneity of academic data may impact the acquisition of published research information. Due to the large number, heterogeneity, and varying quality of publications related to mTOR and breast cancer, sorting out the present state of the research in this area is critical for both researchers and clinicians. Therefore, scientometric techniques and visualization tools were employed to analyze the large number of bibliographic metadata related to the research area of mTOR and breast cancer. The features of relevant publications were searched from 2012 to 2022 to evaluate the present status of research and the evolution of research hotspots in this particular field. Web of Science was utilized to extract all relevant publications from 2012 to 2022. Subsequently, Biblioshiny and VOSviewer were utilized to obtain data on the most productive countries, authors, and institutions, annual publications and citations, the most influential journals and articles, and the most frequently occurring keywords. In total, 1,471 publications were retrieved, comprising 1,167 original articles and 304 reviews. There was a significant rise in publications between 2015 and 2018, followed by a sharp decline in 2019 and a rebound since then. The publication with the highest number of citations was a 2012 review authored by Baselga et al. The United States had the highest number of publications, citations and connections among all countries. Oncotarget had the highest number of published articles among all the journals, and José Baselga had the strongest links with other authors. Excluding the search topics, the most frequently used words were “expression” (n = 297), “growth” (n = 228), “activation” (n = 223), “pathway” (n = 205), and “apoptosis” (n = 195). mTOR is crucially involved in breast cancer pathogenesis, but its exact mechanism of action remains controversial and warrants further investigation. The scientometric analysis provides a distinct overview of the existing state of research and highlights the topical issues that deserve further exploration.