bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-trivial solutions and their stability in a two-degree-of-freedom Mathieu-Duffing system
Authors: Barakat Ahmed A. , Weig Eva M. , Hagedorn Peter 
Published: December 2022

Abstract
The Mathieu-Duffing equation represents a basic form for a parametrically excited system with cubic nonlinearities. In multi-degree-of-freedom systems, other interesting instability conditions take place and are considered in this work. Accordingly, the non-trivial solutions are obtained, especially when the trivial solution is unstable. At resonant frequencies a bifurcation analysis is carried out using the multiple scales method, followed by investigating the effect of an asynchronous parametric excitation. Since various micro- and nano-systems include cubic nonlinearities and subjected to parametric excitation, this work should be of relevant importance.
Genome-wide characterization and comparative analysis of the OSCA gene family and identification of its potential stress-responsive members in legumes
Authors: Chakraborty Srija , Gangwar Rashmi , Zahra Shafaque , Poddar Nikita , Singh Amarjeet , Kumar Shailesh 
Published: December 2022

Abstract
Cicer arietinum, Cajanus cajan, Vigna radiata, and Phaseolus vulgaris are economically important legume crops with high nutritional value. They are negatively impacted globally by different biotic and abiotic stresses. Hyperosmolality-gated calcium-permeable channels (OSCA) have been characterized as osmosensors in Arabidopsis thaliana, but not previously reported in legumes. This study provides a genome-wide identification, characterization and comparative analysis of OSCA genes in legumes. Our study identified and characterized 13 OSCA genes in C. cajan, V. radiata, P. vulgaris and 12 in C. arietinum, classified into four distinct clades. We found evidence to suggest that the OSCAs might be involved in the interaction between hormone signalling pathways and stress signalling pathways. Furthermore, they play a major role in plant growth and development. The expression levels of the OSCAs vary under different stress conditions in a tissue-specific manner. Our study can be used as a platform to develop a detailed understanding of stress regulatory mechanisms of the OSCA gene family in legumes.
Microsphere-assisted digital holographic microscopy integrated with on-line thermal lens spectrometry for 3D imaging and enhanced photothermal detection
Authors: Kabi Sareh , Moradi Ali-reza , cabrera Humberto 
Published: December 2022

Abstract
Acquiring morphological and photothermal information is essential for characterization of a variety of samples in biochemistry, material science and process technologies. In this paper, we report on the integration of digital holographic microscopy (DHM) and thermal lens (TL) spectrometry techniques enabling simultaneous measurement of both class of properties: morphological images and photothermal parameters. DHM in transmission mode is an effective technique for label-free, non-contact, real-time, and non-invasive imaging and measurement of phase objects, such as biomaterials. On the other hand, TL is a highly sensitive methodology to detect low concentrations of analytes in low absorbing samples. We demonstrate the usefulness of the DHM-TL integrated system by applying it to obtain morphometrical information of samples as well as for acquisition of their photothermal maps. Further, by extending the concept of “microsphere-assisted (MS) imaging” into TL, we show that MS-TL enables detection and counting of particles, which otherwise their photothermal signals cannot be detected. The system has the potential to be applied for a variety of objects including bio-samples and may be proposed as a bench-top characterization device.
Modeling of Tow-to-spot Diameter Ratio for Laser Cutting of Single-layer Carbon Fiber Reinforced Plastics (CFRP)
Authors: Luo Yonghao , Zhu Xiaowu , Zhang Weiye , Chang Cheng , Gao Shuohong , Lu Bingwen , Yan Xingchen 
Published: December 2022

Abstract
Carbon fiber reinforced plastics (CFRP) is a kind of advanced composite material with resin as matrix and carbon fiber as reinforcing phase. Laser cutting is considered as a high-efficiency and high-quality processing method of CFRP because of its high removal rate, narrow slit and no cutting force. Due to the differences in physical properties between carbon fiber and resin in CFRP, the whole composed of these two phases in different arrangement is a typical anisotropic material, which leads to the high complexity of its laser cutting process compared with isotropic materials. In order to study the influence of material anisotropy on energy conduction in laser cutting CFRP, taking single-layer CFRP as the research object, based on the heat conduction theory and the mixing rate of composite materials, the three-dimensional finite element models of single fiber arrangement with tow-to-spot diameter ratio of 1:1, 1:2, 1:5 and 1:10 are established by using the commercial software ANSYS. Through the numerical simulation of the same direction laser cutting process, the material temperature field and cross-section temperature gradient are analyzed. The results show that with the increase of fiber arrangement density (tow-to-spot diameter ratio approaching 1:10), the width of heat affected zone decreases, but the maximum temperature increases, which means that the temperature gradient increases. Therefore, it is speculated that when laser cutting with large spot diameter is used, i.e. K < 1:10, CFRP can be treated as homogeneous composite. In order to verify the effectiveness of the model, a slit aperture is used to control the tow-to-spot diameter ratio at about 1:7, and a CO2 continuous laser is used for cutting experiments. By fitting the experimental measurements with the width of carbon fiber ablation area and heat affected zone in the numerical simulation results, it is found that there is a logarithmic correlation between both of the width and the tow-to-spot diameter ratio. There are 3.37% and 1.92% deviations between the experimental result and the theoretical value, respectively. The agreement is relatively good, which can prove the effectiveness of the model. In conclusion, the establishment of tow-to-spot diameter ratio model reveals the response characteristics of anisotropic materials to energy input and conduction in the process of laser cutting, especially the difference of radial and axial conduction efficiency. The influence mechanism of fiber arrangement mode (mainly density in this work) on temperature field and cutting effect is clarified, which provides important theoretical support and experimental basis for laser precision cutting method of CFRP materials.
Drivers of retention of the HIV workforce transitioned from PEPFAR support to the Uganda government payroll
Authors: Zakumumpa Henry , Rujumba Joseph , Kyomuhendo Marjorie , Stempler Ilyse , Amde Woldekidan 
Published: December 2022

Abstract
Background
Health worker (HW) retention in the public health sector in Uganda is an enduring health system constraint. Although previous studies have examined the retention of in-service HWs, there is little research focusing on donor-recruited HWs with private-sector work backgrounds. The objective of this study was to explore drivers of retention of the HIV workforce transitioned from PEPFAR support to the Uganda government payroll between 2015 and 2017.
Methods
We conducted ten focus group discussions with HWs (n = 87) transitioned from PEPFAR support to the public sector payroll in 10 purposively selected districts across Uganda. Qualitative interviews were conducted with national-level stakeholders (n = 17), district health and personnel officers (n = 15) and facility in-charges (n = 22). Data were analyzed by thematic approach as guided by the analytical framework proposed by Schaefer and Moos regarding individual-level and organizational-context drivers.
Results
At the individual level, job security in the public sector was the most compelling driver of health worker retention. Community embeddedness of HWs in the study districts, opportunities for professional development and career growth and the ability to secure salary loans due to ‘permanent and pensionable’ terms of employment and the opportunity to work in ‘home districts’ where they could serve their ‘kinsmen’ were identified as enablers. HWs with prior private sector backgrounds perceived public facilities as offering more desirable challenging professional work. Organizational context enablers identified include perceptions that public facilities had relaxed supervision regimes and more flexible work environments. Work environment barriers to long-term retention include frequent stock-out of essential commodities, heavy workloads, low pay and scarcity of rental accommodation, particularly in rural Northern Uganda. Compared to mid–cadres (such as nurses and midwives), higher-calibre cadres, such as physicians, pharmacists and laboratory technologists, indicated a higher affinity to seek alternative employment in the private sector in the immediate future.
Conclusion
Overall, job security was the most compelling driver of retention in public service for the health workforce transitioned from PEPFAR support to the Uganda government payroll. Monetary and non-monetary policy strategies are needed to enhance the retention of upper cadre HWs, particularly physicians, pharmacists and laboratory technologists in rural districts of Uganda.
Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract
Authors: Knieling Ferdinand , Paulus Lars-Philip , Buehler Adrian , Wagner Alexandra , Raming Roman , Jüngert Jörg , Simon David , Tascilar Koray , Schnell Alexander , Rother Ulrich , Lang Werner , Hörning André , Schett Georg , Neurath Markus , Waldner Maximilian , Trollmann Regina , Wölfle Joachim , Bohndiek Sarah , Regensburger Adrian , Eckstein Markus 
Published: December 2022

Abstract
Real-time imaging and functional assessment of the intestinal tract and its transit poses a significant challenge to traditional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular-sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in tissue. Herein we present a novel approach using the orally administered clinical-approved fluorescent dye indocyanine green (ICG) for bed-side, non-ionizing evaluation of gastrointestinal passage. We were able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple timepoints over eight hours after ingestion of a standardized meal with and without ICG. ICG signals could be visualized and quantified in different intestinal segments, while its excretion was confirmed by fluorescent imaging of stool samples. These findings indicate that contrast-enhanced MSOT (CE-MSOT) provides a translatable real-time imaging approach for functional assessment of the gastrointestinal tract.
Engineering Nanoenzymes Integrating Iron-based MOFs with Pt NPs for Enhanced PDT-Ferroptosis Therapy
Authors: Ye Yuyun , Yu Hongli , Zhao Yifan , Bai Lv , Xue Guanghe , Sun Yong , Cao Jie 
Published: December 2022

Abstract
Background
Photodynamic therapy (PDT), as a promising strategy in cancer treatment that utilizes photosensitizers (PSs) to produce reactive oxygen species (ROS), has been widely used for eliminating cancer cells under specific wavelength light irradiation. However, the low aqueous solubility of PSs, and special tumor environments (TME), such as high glutathione (GSH) and tumor hypoxia remain challenges towards PDT for hypoxic tumor treatment.
Results
To address these problems, we constructed a novel nanoenzyme (HMPC) for enhanced PDT-ferroptosis therapy by integrating small Pt nanoparticles (Pt NPs) and near-infrared photosensitizer CyI into iron-based metal organic frameworks (MOFs). In addition, hyaluronic acid (HA) was adhered to the surface of the nanoenzymes to enhance the targeting ability. In this design, MOFs act not only as a delivery vector for PSs, but also a ferroptosis inducer. Pt NPs stabilized into MOFs were functioned as an oxygen (O2) generator by catalyzing hydrogen peroxide (H2O2) into O2 to relieve tumor hypoxia and increase 1O2 generation. In vitro and in vivo results demonstrated that under NIR irradiation, HMPC could effectively relive the tumor hypoxia and decrease the level of GSH in TME, resulting in enhanced PDT-ferroptosis therapy against hypoxic tumor.
Conclusion
The proposed nanoenzymes represent an important advance in altering TME for improved clinical PDT-ferroptosis therapy, as well as their potential as effective theranostic agents for hypoxic tumors.
A unified fracture model for X65 pipeline material under various constraints using the eXtended finite element method (XFEM)
Authors: Sichani Mohammadmehdi Shahzamanian 
Published: December 2022

Abstract
It is generally accepted that the fracture strain is dependent on geometry/constraints in metals. However, the current available implementation of XFEM assumes a fixed fracture strain criterion independent of the constraints. The objective of this paper is to develop and implement a variable fracture strain criterion in XFEM that is capable of predicting a wide range of fracture conditions in X65 pipeline steels with various crack tip constraints. Various small-scale tests with different out of plane constraints obtained from the literature were simulated using the XFEM in ABAQUS software. These tests included smooth bar, notched bar, single edge notch tension (SENT), and single edge notch bending (SENB) tests. For each test, the value of the maximum principal strain (Maxpe) as a fracture initiation criterion in the cohesive zone model (CZM) in XFEM framework was varied while keeping the fracture energy constant until the model was able to accurately replicate the reported experimental results. For each test, the crack tip constraints were characterized and the stress triaxialities and Lode angle parameters at the onset of fracture initiation were calculated from the models. The results allowed expressing the fracture strain as an explicit function of stress triaxiality which was then implemented in ABAQUS XFEM using UDMGINI subroutine. For the sake of comparison, the tests were simulated in finite element method (FEM) using a similar damage initiation model namely, the Johnson-Cook (J-C) model. A single model in XFEM was able to accurately replicate the experimental observations for all specimens and compared well to experiments in the way simulated by FEM damage model. However, it was observed that XFEM was more suitable to simulate specimens with pre-existing cracks such as in SENT and SENB tests since the crack grew through elements when mesh refinement was not required around the crack tips. Lastly, the simulated results were found to be less mesh sensitive in XFEM than in FEM damage models.
Cost-Utility Analysis of a Supervised Exercise Intervention for Women with Early-Stage Endometrial Cancer
Authors: Wang Yufan , McCarthy Alexandra L. , Tuffaha Haitham 
Published: December 2022

Abstract
Purpose

Cardiovascular disease (CVD) is the leading cause of death after treatment for endometrial cancer (EC). There is clinical evidence that exercise significantly reduces the risks of CVD and cancer recurrence; however, it is unclear whether there is value for money of integrating exercise into clinical cancer care for women treated for EC. This study aims to assess the long-term cost-effectiveness of a 12-week supervised exercise intervention for women diagnosed with early-stage EC compared to standard care.

Method

A cost-utility analysis was conducted from the Australian health system perspective. A Markov cohort model was designed with six mutually exclusive health states: i) No CVD, ii) Post-stroke, iii) Post-coronary heart diseases (CHD), iv) Post-heart failure, v) Post-cancer recurrence, vi) Death. The model was populated using the best available evidence in the literature. The cohort was followed for a time horizon of 5 years. Costs and outcomes were discounted at 5% annual rate. The incremental cost-effectiveness ratio (ICER) and net monetary benefit were estimated. Decision uncertainty was characterised using univariate and probabilistic sensitivity analysis.

Result

The incremental cost of supervised exercise versus standard care was AUD $496 and the incremental QALY was 0.064, resulting in an ICER of AUD $9,148 per QALY gained. The likelihood that the supervised exercise intervention was cost-effective at a willingness-to-pay threshold of AUD $50,000 per QALY was 97.8%.

Conclusion

This is the first economic evaluation of exercise after treatment for EC. The results suggest that exercise is cost-effective in this population.

Implications for Cancer Survivors

Given the low uncertainty in the results, efforts should focus on implementation of exercise as part of clinical cancer care.
Marginally Trapped Ruled Surfaces and Their Gaussmap in Minkowski Space
Authors: Jung Sun Mi , Kim Young Ho 
Published: December 2022

Abstract
In 1991, B. -Y. Chen proposed a conjecture which is the relationship between bi-harmonic submanifolds and harmonic submanifolds in Euclidean space and quite a few related studies have supported it. Around the same time, it was proved that Chen’s conjecture does not extend to submanifolds in Minkowski space. In this paper, as part of these researches, we investigate bi-harmonic marginally trapped ruled surfaces in Minkowski m-space and then construct some examples about them in which Chen’s conjecture does not hold.
Hourglass Shell Design of a Wooden Material for Making Talking Drum, and Their Sound Properties
Authors: Olaoye K.O. , Oluwadare A. O. 
Published: December 2022

Abstract
The talking drum is gaining a wide acceptance in the music industry. However, it sometimes perform below expectation when in service, thus necessitating different research studies. To optimizing the sound properties of a talking drum, we explored the contribution of the design of the wooden hourglass shell making the talking drum. We fell three fifteen year old Gmelina arborea trees, and collected bolts from their base wood to make the hourglass shell designs comprising six geometric shapes (Funnel, Twofoil, Inverted Crescent, Cone, Half-ellipse, and Conic Rectangular) and three interior finishes (rough, smooth, and glazed). Hence, the making of the drums. Test were carried out at no extension (ne) and extension limit (el) on the tension cord, while sound frequency, amplitude, timbre harmonic, and sound damping time (SDT) measured had mean of 107.70Hz, 43.85dB, 0.11, 646.66ms at ne, and 243.93Hz, 46.55dB, 0.12, 800.92ms at el, respectively. The significant interaction between the geometric shapes and interior finishes implies that the design of the hourglass shell influenced the amplitude, timbre harmonic and SDT only. At the end of the study, we found that SDT of a talking drum can be greatly optimized by glazing the interior surface of a Cone hourglass shell.
A framework for stakeholder engagement in the adoption of new antimalarial treatments in Africa: a case study of Nigeria
Authors: Mokuolu Olugbenga Ayodeji , Bolarinwa Oladimeji Akeem , Opadiran Oluwatumobi Racheal , Ameen Hafsat Abolore , Dhorda Mehul , Cheah Phaik Yeong , Amaratunga Chanaki , Haan Freek , Tindana Paulina , Dondorp Arjen M. 
Published: December 2022

Abstract

Introduction:
Recent reports of artemisinin partial resistance from Rwanda and Uganda are worrisome and suggest a future policy change to adopt new antimalarials. We conducted a case study on the evolution, adoption, and implementation of new antimalarial treatment policies in Nigeria. The main objective is providing perspectives to enhance the future uptake of new antimalarials, with an emphasis on stakeholder engagement strategies.
Methods
This case study is based on an analysis of policy documents and stakeholders’ perspectives drawn from an empirical study conducted in Nigeria, 2019–2020. A mixed methods approach was adopted, including historical accounts, review of programme and policy documents, and qualitative in-depth interviews and focus group discussions. Themes for the framework were developed and applied to the case study.
Results
Based on policy documents reviewed, the adoption of artemisinin-based combination therapies (ACTs) in Nigeria was swift due to political will, funding and support from global developmental partners. However, implementation of ACTs was met with resistance from suppliers, distributors, prescribers, and end-users, attributed to market dynamics, costs and inadequate stakeholder engagement. Deployment of ACTs in Nigeria witnessed more developmental partner support, robust data generation, ACT case-management strengthening and evidence on antimalarial use in severe malaria and antenatal care management. We propose a framework for effective stakeholder engagement for future adoption of new antimalarials or antimalarial treatment strategies. The framework covers the pathway from generating evidence to making treatment accessible and affordable to end-users. It addresses who to engage with, the content of engagement and what strategies would support effective engagement with key stakeholders at different levels of the transition process.
Conclusion
Early and staged engagement of stakeholders from global bodies through regulatory authorities to end-users at the community level is critical to the successful adoption and uptake of new antimalarial treatment policies. A framework for these engagements has been proposed as a unique contribution to enhancing this process.
Automating Control of Overestimation Bias for Reinforcement Learning
Authors: Kuznetsov Arsenii , Grishin Alexander , Tsypin Artem , Ashukha Arsenii , Kadurin Artur , Vetrov Dmitry 
Published: December 2022

Abstract
Majority of high-performing off-policy reinforcement learning algorithms use aggregated overestimation bias control techniques.However, most of them rely on a pre-defined bias correction policies that are either not flexible enough or require environment-specific tuning of hyperparameter.In this work, we present a data-driven approach for automatic bias control.We demonstrate its effectiveness on three algorithms: Truncated Quantile Critics, Weighted Delayed DDPG and Maxmin Q-learning. Our approach eliminates the need for an extensive hyperparameter search.We show that it leads to the significant reduction of the actual number of interactions while, in most cases, matching the performance of a resource demanding grid search method.While on average the reduction of the bias improves the performance, elimination of the aggregated bias does not always lead to the best performance. To the best of our knowledge, that is the first case where it is proven on complex environments which highlights the important pitfalls of overestimation control.