bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological characteristics of endometrial cancer patients treated at a tertiary health center in National Capital Territory of India
Authors: Agarwal Shruti , Melgandi Wineeta , Sonkar Deepak Raj , Ansari Faiz Akram , Arora Savita , Rathi Arun Kumar , Singh Kishore 
Published: June 2023

ABSTRACT

Settings and Design:
A retrospective study which analyzed the data of female patients attending a tertiary care center in National Capital Territory for the treatment of endometrial cancer.

Materials and Methods:
Eighty-six histopathologically confirmed cases of carcinoma endometrium were taken from January 2016 to December 2019. Detailed information was collected regarding patient’s case history, sociodemographic data (age of presentation, occupation, religion, residence, and substance addiction), clinical presentation, diagnostic and therapeutic procedures, and known risk factors (age at menarche and menopause, parity, obesity, use of oral contraceptive pills, hormone replacement therapy, and comorbidities such as hypertension and diabetes).

Statistical Analysis Used:
After analysis, results were presented as mean ± standard deviation and frequency.

Results:
Eighty-six percent of the patients (n = 73) were in the age group of 40–70 years; the mean age of the patients at diagnosis of endometrial cancer was 54 years. Eighty-one percent (n = 70) of the patients were from urban areas. Sixty-seven percent of the females (n = 54) were Hindu. All the patients were housewives with nonsedentary lifestyles. Most patients (88%; n = 76) presented with bleeding per vaginum. Fifty-nine percent (n = 51) had stage I disease, followed by 15% (n = 13) with stage II, 14% (n = 12) with stage III, and 12% (n = 10) with stage IV disease. Eighty-two percent (n = 72) of the patients had endometrioid carcinoma. Other less common variants were mixed Mullerian malignant tumor, squamous, adenosquamous, serous, and endometrioid stromal. Forty-four percent (n = 38), 39% (n = 34), and 16% (n = 14) of the patients had grade I, grade II, and grade III tumor, respectively. 53.5% of the cases (n = 46) had >50% myometrial invasion at the time of presentation. Eighty-two percent (n = 71) of the patients were postmenopausal. The mean age at menarche and menopause was 13 years and 47 years, respectively. Fifteen percent (n = 13) of the females were nulliparous. Forty-six percent (n = 40) of the patients were overweight. Most patients (82%) had no history of addiction. Twenty-five percent (n = 22) of the patients had hypertension, and 27% (n = 23) has diabetes as comorbidity.

Conclusions:
The incidence of endometrium cancer is showing a steady rise in the recent past. Early age of menarche, late age of menopause, nulliparity, obesity, and diabetes mellitus are well-documented risk factors for uterine cancer. Better outcome and control of disease is possible by understanding of endometrial cancer etiology, risk factors, and its preventive measures. Thus, a robust screening program is warranted to detect the disease in early stage and for increased survival.
Particular aspects of treating rectal cancer: The watch and wait approach
Authors: Draghici Diana Andreea , Stoian Alexandru Rares , Porojan Vlad Andrei , David Oana Ilona , Bedereag Ştefan , Ciuhu Anda Natalia , Haidar Andrei , Crețoiu Dragoş , Condrat Carmen Elena , Grigorean Valentin Titus 
Published: June 2023

ABSTRACT

Background:
Rectal cancer is one of the most common malignant pathologies worldwide. Currently, the standard treatment of this pathology consists of radio-chemotherapy followed by low anterior resection with total mesorectal excision or abdominoperineal proctectomy for medium/low rectal cancer.

Objectives:
In recent years, another treatment strategy has been proposed, stemming from the finding that up to 40% of patients receiving neoadjuvant treatment had a complete pathological response. This method, also referred to as the watch and wait approach, implies delaying surgery and following a rigorous protocol for patients who have developed a complete response to neoadjuvant treatment with a good oncologic outcome. The objective of this study was to highlight the merits of this approach in selected patients.

Case Reports:
In this study, we present two patients with low-rectal tumors who developed complete response post neoadjuvant therapy and for whom the watch and wait protocol has been applied over the past 4 years.

Conclusion:
Although the watch and wait protocol appears to be a feasible option in the management of patients with a complete clinical and pathological response post neoadjuvant therapy, more prospective studies and randomized trials comparing this approach with standard surgical treatment are required before establishing it as the standard of care for distal rectal cancer. Therefore, establishing universal criteria for the selection and assessment of the patients with a complete clinical response following neoadjuvant treatment is required.
Co-administration of pazopanib and enteral nutrition with omega-3 fatty acids as a safety issue in a patient treated for metastatic clear cell renal cancer: A case report
Authors: Jović Zlatović Josipa , Omrčen Tomislav , Marijanović Inga , Kraljević Marija 
Published: June 2023

ABSTRACT
Pazopanib is an oral multitargeting tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFRs), approved as the first-line treatment of metastatic renal cell carcinoma (mRCC) and soft tissue sarcoma (STS) at a fixed dose of 800 mg daily taken fasted. Potential drug–meal interactions and adverse events (AEs) may lack recognition and the related data in literature. We report one case of stomatitis/oral mucositis associated with pazopanib administrated with an oral nutritional supplement enriched with omega-3 fatty acids. The 50-year-old patient with mRCC started pazopanib treatment at standard doses of 800 mg daily as first-line therapy for mRCC, and after a few days, he developed stomatitis. Co-administration of pazopanib with high-fat meals could increase the solubility of highly lipophilic pazopanib, increasing its plasma pazopanib area under the curve (AUC), and maximum concentration (Cmax) above optimal therapeutic level can consequently lead to increased frequency/grade of AEs.
Induction chemotherapy in head and neck cancer – Boon or bane?
Authors: Mall Aprajita , Negi Preety , Philip Ashwin Oommen , Kingsley Pamela A. 
Published: June 2023

ABSTRACT

Introduction:
Although concurrent chemoradiotherapy is the standard of care for inoperable locally advanced head and neck cancer, induction chemotherapy is considered an alternative approach by head and neck oncologists worldwide.

Aims:
To evaluate the response to induction chemotherapy in terms of loco-regional control and treatment-related toxicity in inoperable locally advanced head and neck cancer patients.

Materials and Methods:
This prospective study was conducted on patients who received two to three cycles of induction chemotherapy. Following this, response assessment was performed clinically. Grading of radiation-induced oral mucositis and any interruptions in treatment were noted. At 8 weeks following treatment, magnetic resonance imaging-based radiological response assessment was performed using RECIST criteria version 1.1.

Results:
Our data revealed 57.7% complete response rate with induction chemotherapy, followed by chemoradiation therapy. We observed that post induction, 67.5% and 47.5% patients had reduction in T-stage (<0.001) and N-stage of disease (<0.001), respectively, with complete response more achieved in younger patients (≤50 years). Chemotherapy-induced bone marrow suppression and febrile neutropenia occurred in 7.5% patients. We demonstrated that a higher grade of radiation-induced mucositis was noticed among those receiving three cycles of induction chemotherapy (ICT) and aged >50 years.

Conclusion:
We conclude that induction chemotherapy could still be a viable option for down-staging unresectable locally advanced disease, especially for younger patients in terms of better treatment response and tolerability. The number of cycles of ICT seems to influence radiation-induced mucositis. This study underscores the need for further studies to determine the exact role of ICT in locally advanced head and neck cancer.
Clinical diagnosis and management of persistent idiopathic dentoalveolar pain
Authors: Singh Reetika , Nikhil Vineeta , Sahu Sonal 
Published: June 2023

Introduction:
Persistent idiopathic dentoalveolar pain (PIDP) is a type of chronic pain that affects the teeth and surrounding tissue, and it is a condition that has been puzzling dental practitioners for many years.

Aim:
To clarify some misconceptions about persistent idiopathic dentoalveolar pain and provides insight into its possible diagnoses.

Methods:
The electronic literature search was conducted between June 2003 and December 2022 in PubMed and Google Scholar using Mesh terms: pain, idiopathic pain, phantom pain, and dentoalveolar pain in the English language. Later, relevant articles were screened and read thoroughly.

Results:
After reviewing the various articles, it was found that PIDP is a disease of exclusion that is confined to the dentoalveolar region with profound, dull, and pressure-like sensations.

Discussion:
Most of the research on PIDP has centered on its occurrence rates, symptoms, and ways to treat it, as well as the possible causes behind it. Various studies have also investigated different forms of treatment, such as medication, nerve blocks, and psychological interventions, in an effort to manage PIDP.
Proposta de leitura de Uma Escuridão Bonita, de Ondjaki, para o ensino fundamental II
Authors: Da Rocha Maquêa Vera Lúcia , Greff Paula Adriana 
Published: June 2023

O estudo que apresentamos, elaborado no âmbito do curso de Mestrado Profissional em Letras – Profletras, Unemat/Cáceres, trata-se de uma proposta de leitura para o ensino fundamental II, com o objetivo de fomentar a prática de leitura do texto literário, tendo como objeto de trabalho a ficção juvenil Uma Escuridão Bonita (2018), de Ondjaki, cuja temática abrange a descoberta de si e o amadurecimento pessoal. Abordaremos a obra, num primeiro momento, sob a perspectiva da leitura subjetiva e, no decorrer do processo, confrontaremos as subjetividades expressas para que a interpretação não fique só na superficialidade do texto. Neste percurso, o estudante será provocado a refletir sobre o que o levou a projetar algo que não estava no texto, favorecendo assim, a formação de um leitor consciente. Por outra frente, estimularemos que o aluno submeta-se ao texto, não no sentido de deixar-se conduzir por ele, mas para vivenciar a experiência literária como um acontecimento singular e modificador.
Palavras-chave: Ficção juvenil. Leitura subjetiva. Formação do leitor.
Prevalence of low genital tract colonization by mycoplasma, ureaplasma and bacterial vaginosis
Authors: Phung Thi Ly , Nguyen Thu Hoai , Tran Thi Thu Ha , Nguyen Thi Huong Linh , Nguyen Thi Thu Ha , Nguyen Thi Tan Sinh , Tran Manh Linh 
Published: June 2023

Objectives: To determine the prevalence of low genital tract colonization by Mycoplasma, Ureaplasma and its association with bacterial vaginosis
Materials and Methods: A cross-sectional study carry on 802 women who were visited at Vinmec International Hospital from January 2021 to January 2022. M. genitalium, M. hominis, U. urealyticum, U. parvum in low genital tract sample were detected by Realtime - PCR method. Diagnosis of bacterial vaginosis based on microbiological morphology according to Nugent score. Abnormal cases are treated and followed.
Results: The prevalence of M. genitalium was 1.6% (95%CI: 0.9 - 2.8), M. hominis was 5.0% (95%CI: 3.6 – 6.8), U. urealyticum was 13.1% (95%CI: 10.7 - 15.9) and U. parvum was 36.0% (95%CI: 32.0 - 40.4). Mycoplasma and Ureaplasma present in lower genital tract samples were not associated with clinical symptoms. The rate of bacterial vaginosis was 4.7% and it was not associated with the presence of M. genitalium, M. hominis, U. urealyticum, U. parvum in low genital tract.
Conclusion: The prevalence of Mycoplasma and Ureaplasma in the genital tract is relatively low and it was not associated with bacterial vaginosis.
PENGARUH KEMATANGAN BUAH KELAPA SAWIT VARIETAS DXP BAH LIAS TERHADAP KADAR MINYAK SAWIT MENTAH (CPO)
Authors: Feny Rahmadhania  , Sembiring Pardamenta , Marshal Arifin Sinaga  
Published: June 2023

>One of the successes of processing at the Palm Oil Mill (POM) is the quality of the raw material for Fresh Fruit Bunches (FFB). The degree of maturity of FFB at harvest is related closely to CPO oil content and free fatty acid content (FFA). One of the varieties grown on oil palm plantations is the DxP Bah Lias variety produced by Bah Lias Research Station (BLRS). The study was conducted in April - June 2017 at the Laboratory of PT. Betami in Kuala Simpang, Aceh Tamiang. FFB samples were obtained from Division I of the Rantau Garden PT. Betami. The study aims to determine the effect of maturity fraction of oil palm FFB on the levels of CPO. The fractions studied were 0, 1, 2, 3, and 4 fractions. The results showed that the highest CPO yield was fraction 3, 26.1% and the lowest fraction 0 with a yield of 22%.
Analisys of The Effect of Fisherman, Fishing Boat, and Fishery Ports on Catching Fisheries Production in East Java Province
Authors: Aida Gilang Rusrita , Illahi Rhochmad Wahyu , Pramesthy Tyas Dita 
Published: June 2023

The importance of the fisheries sector for East Java Province can be seen from the high capture fisheries production compared to other provinces di Indonesia. In 2021, East Java Province is listed as the province with the highest capture fisheries production in Indonesia. This is suspected to be affected by several factors i.e the numberi of fishermen, fishing vessels, and fishing ports, so analysis is needed to determinei the effect of these factors on capture fisheries in East Java. The aim of this studyi was to determine the effect of the amount of fishermen, fishing boats, and fishing ports on capture fisheries production in East Java. The research methodi used in this research iis descriptive using secondary data. The data analysis used is multiplei linear regression, F-test, and T-test. Based on the results, the multiple linear regression analysis were obtained by the equation y = 292.543,118 + 0,381 X1-0,722 X2 + 2.838,450 X3 with an adjusted R2 value of 72,7 %. The F test shows a isignificance <0,05, which meansi that the total number of fishermen, fishing boats, and fishing ports have a significant effecti simultaneously on capture fisheries production in East Java. The T-test shows that the numberi of fishing ports has a partially significant effect on marine capture fisheries production in East Java Province (sig. <0,05). Meanwhile, the number ofi fishermen and fishingi boats showed no partially significant effect oni capture fisheriesi production in East Java Province (sig. > 0,05).
Environmental Parameters And Phytoplankton Community Quality: Implications For Food Safety In Coastal Communities
Authors: Tambaru Rahmadi 
Published: June 2023

This study aimed to evaluate environmental parameters and phytoplankton quality as well as the implications for the food safety of seafood-consuming coastal communities. The study was conducted in coastal waters of South Sulawesi, Indonesia at four sites (three stations/site): Pangkep (PK), Kuri (KR), Maros (MR), and Tallo (TL) during June, August, and October 2020. Observations formed three spatial clusters: MR1, PK; MR2, MR3, TL; KR (92.5 % similarity), and two temporal clusters: June 2020; August and October 2020 (87.9 % similarity). PCA showed parameters most strongly characterizing TL, KR, and MR (except MR1) were high levels of salinity, nitrate, nitrite, ammonium, silicate, temperature, pH, and abundance of both phytoplankton that can form harmful algal blooms (HABs) and non-HAB forming phytoplankton (non-HABs), with low current velocity. PK was characterized by high current velocity, non-HABs, orthophosphate, ammonium, nitrite, and turbidity with low nitrate and HABs. Main characterizing parameters in the temporal PCA were high current velocity and HABs with low orthophosphate in June 2020; high nitrate, ammonium, orthophosphate, and non-HABs with even lower HABs in August 2020; high turbidity, temperature, and salinity with low pH, nitrite, silicate, and HABs in October 2020. Current velocity (low at TL, KR, MR and high at PK) influenced both non-HABs and HABs. The results indicate that faster currents may have impeded HABs development so that the phytoplankton quality was still good. Therefore, the fish from these waters can be considered safe for human consumption, thereby contributing to maintaining the health of coastal communities.
FEASIBILITY ANALYSIS OF OPERATION OF PURSE SEINE AS A FISHING VESSEL IN BONE BAY, SOUTH SULAWESI
Authors: Anshari Andi Imran 
Published: June 2023

This study aims to analyze the feasibility of operating purse seine vessels operated in Bone Bay. The sampling method uses purposive sampling. There are 4 ship samples and to facilitate measurement using ships that are docking. The data analyzed are the ratio of the main size of the ship, stability, seaworthiness criteria, and ship operation criteria.
The results showed that the feasibility of operating purse seine vessels operating in Bone Bay, feasible to operate based on the results of the analysis of each parameter. The L/B ratio value of the purse seine vessels studied ranged from 3.73 – 4.59; L/D ranges from 10.72 – 12.58; and B/D ranges from 2.34 – 3.16. The stability curve of sample ship 1 shows a Max GZ value of 163.27 cm at a slower angle of 73.6 deg, sample ship 2 shows a Max GZ value of 159.75 cm at a low angle of 58.2 deg, sample ship 3 shows a Max GZ value of 154.75 cm at a low angle of 60.9 deg and sample ship 4 Data shows a Max GZ value of 139.59 cm at a low angle of 60.9 deg. The criteria value of the sample ship has met the minimum value standards set by the IMO (International Maritime Organization).
Hubungan Konformitas, Kontrol Diri, dan Harga Diri dengan Perilaku Mencontek pada Siswa
Authors: Haryati Siti , Pratisti Wiwien Dinar 
Published: June 2023

Menyontek adalah suatu tindakan atau perlakuan tidak jujur, serta melakukan cara curang untuk mendapatkan nilai yang baik saat ujian atau saat mengerjakan soal setiap pelajaran. Dengan demikian setiap individu harus meningkatkan perilaku yang bisa meminimalisir perilaku mencontek untuk mencapai tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara konformitas, kontrol diri, dan harga diri dengan perilaku mencontek pada siswa. Metode yang digunakan dalam penelitian ini yaitu kuantitatif. Subjek pada penelitian ini sebanyak 204. Alat pengumpulan data menggunakan skala konformitas, kontrol diri, harga diri, dan perilaku mencontek. Data yang didapatkan dianalisis menggunakan teknik analisis regresi linier berganda dengan software SPSS 23 for windows. Hasil analisis regresi berganda menunjukan bahwa nilai sig 0.000, artinya terdapat korelasi antara konformitas, kontrol diri, harga diri, dengan perilaku mencontek. Secara parsial, tidak terdapat korelasi yang signifikan antara konformitas dengan perilaku mencontek dengan nilai signifikan 0.371>0.05. Terdapat hubungan yang signifikan antara kontrol diri dengan perilaku mencontek dengan nilai signifikan 0.010<0.05 dengan sumbangan efektif 0.049%. Terdapat hubungan yang signifikan antara harga diri dengan perilaku mencontek dengan nilai signifikan 0.038<0.05 dengan sumbangan efektif 0.032%. Dengan demikian dapat dikatakan bahwa tidak ada hubungan yang signifikan antara perilaku konformitas dengan perilaku mencontek, serta terdapat hubungan yang signifikan antara kontrol diri, dan harga diri dengan perilaku mencontek.
Synchronizing ice-core and U ∕ Th timescales in the Last Glacial Maximum using Hulu Cave 14C and new 10Be measurements from Greenland and Antarctica
Authors: Sinnl Giulia , Adolphi Florian , Christl Marcus , Welten Kees C. , Woodruff Thomas , Caffee Marc , Svensson Anders , Muscheler Raimund , Rasmussen Sune Olander 
Published: June 2023

Abstract. Between 15 and 27 kyr b2k (thousands of years before 2000 CE) during the last
glacial, Greenland experienced a prolonged cold stadial phase, interrupted
by two short-lived warm interstadials. Greenland ice-core calcium data show
two periods, preceding the interstadials, of anomalously high atmospheric
dust loading, the origin of which is not well understood. At approximately
the same time as the Greenland dust peaks, the Chinese Hulu Cave speleothems
exhibit a climatic signal suggested to be a response to Heinrich Event 2, a
period of enhanced ice-rafted debris deposition in the North Atlantic. In
the climatic signal of Antarctic ice cores, moreover, a relative warming
occurs between 23 and 24.5 kyr b2k that is generally interpreted as a
counterpart to a cool climate phase in the Northern Hemisphere. Proposed
centennial-scale offsets between the polar ice-core timescales and the
speleothem timescale hamper the precise reconstruction of the global
sequence of these climatic events. Here, we examine two new 10Be
datasets from Greenland and Antarctic ice cores to test
the agreement between different timescales, by taking advantage of the
globally synchronous cosmogenic radionuclide production rates. Evidence of an event similar to the Maunder Solar Minimum is found in the
new 10Be datasets, supported by lower-resolution radionuclide data from Greenland and 14C in the Hulu Cave speleothem, representing a good synchronization candidate at around 22 kyr b2k. By matching the respective 10Be data, we determine the offset between the Greenland ice-core chronology, GICC05, and the Antarctic chronology for the West Antarctic Ice Sheet Divide ice core (WDC), WD2014, to be 125 ± 40 years. Furthermore, via radionuclide wiggle-matching, we determine the offset between the Hulu speleothem and ice-core timescales to be 375 years for GICC05 (75–625 years at 68 % confidence) and 225 years for WD2014 (−25–425 years at 68 % confidence). The rather wide uncertainties are intrinsic to the wiggle-matching algorithm and the limitations set by data resolution. The undercounting of annual layers in GICC05 inferred from the offset is hypothesized to have been caused by a combination of underdetected
annual layers, especially during periods with low winter precipitation, and
misinterpreted unusual patterns in the annual signal during the extremely
cold period often referred to as Heinrich Stadial 1.
Una agenda común de investigación crítica sobre los niños en los mundos mayoritarios y minoritarios. El caso de los niños en los procesos migratorios. SESIÓN DE DEBATE
Authors: Gaitán Lourdes 
Published: June 2023

Con motivo de la elaboración de este número monográfico de Sociedad e Infancias, el consejo editorial de la revista convocó una sesión de debate online el 29 de marzo de 2023.
De manera orientativa se plantearon los siguientes temas de discusión:

Los niños como actores en los procesos migratorios.
¿Son personas con sus propios proyectos migratorios?
¿Incluso cuando son parte de un proyecto de migración familiar?
Influencia de la visión eurocéntrica de la infancia en las políticas y disposiciones normativas de los estados.
Infancia migrante, retos para la sociedad de acogida: alojamiento, escuela, emancipación y transición a la vida adulta.
Cómo aplicar una sociología crítica de la infancia al estudio de las migraciones infantiles.

La sesión tuvo una duración de una hora y treinta minutos y fue grabada y transcrita. A continuación, damos paso a su contenido.