bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Non-surgical Periodontal Treatment on Cytokines/Adipocytokines Levels Among Periodontitis Patients with or without Obesity: A Systematic Review and Meta-analysis
Authors: Zhang Yuwei , Jia Ru , Zhang Yifei , Sun Xuefei , Mei Yukun , Zou Rui , Niu Lin , Dong Shaojie 
Published: February 2023

Abstract
Aim
The objective of this systematic review and meta-analysis was to provide scientific evidence for clinical practice on the impact of non-surgical periodontal therapy (NSPT) on cytokines/adipocytokines (IL-6, TNF-a, CRP/hs-CRP, resistin, adiponectin, leptin and RBP4) among periodontitis patients with or without obesity.
Materials & Methods of Study Selection
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) has been followed. The study was registered (CRD42022375331) in the International prospective register of systematic reviews (PROSPERO). The literature search was conducted via eight databases. Both randomized-controlled trials (RCTs) and controlled clinical trials (CCTs) were screened from searches up to December 2022 to evaluate the effect of NSPT on inflammatory-related cytokines/adipocytokines. The selection, extraction of data and risk of bias assessment were performed in duplicate with consensus while quality was assessed via the Cochrane Collaboration’s risk assessment tool and the Methodological Index for non-randomized studies (MINORS). Meta-analysis was carried out using random-effect model in subgroups’ analyses with mean difference (MD) and 95% confidence intervals (CI) provided.
Results
Seventeen references were included for the systematic analysis and sixteen were further incorporated for meta-analysis. Meta-analysis demonstrated that the interleukin (IL) -6 in periodontitis individuals with obesity decreased three months after NSPT at serum levels (MD = -0.54, CI = -0.62 – -0.46) and at gingival crevicular fluid (GCF) levels (MD = -2.70, CI = -4.77 – -0.63); the C-reactive protein/ high-sensitivity-C-reactive protein (CRP/hs-CRP) decreased three months after NSPT at serum levels (MD = -0.31, CI = -0.54 – -0.07) and adiponectin improved three months after NSPT at GCF levels (MD = 2.37, CI = 0.29–4.45) both in periodontitis individuals without obesity. Most results displayed the higher level of pro-inflammatory biomarkers in obesity object rather than normal weight object at baseline. Incorporated studies are presented with low risk of bias.
Conclusions
NSPT has the impact on the redistribution of specific pro-inflammatory mediators and anti- inflammatory mediators in biological fluids within obesity or non-obesity individually or between the two groups. Wherein, NSPT could contribute to the reduction of serum and GCF IL-6 level together with the serum RBP4 level in obesity individuals at 3-month, NSPT also could contribute to the rise of GCF adiponectin level in normal weight individuals at 3-month, which implies the potential ideal follow-up interval and sensitive biomarkers for clinical bioanalysis.
Body Mass Index trends in men’s Grand Tour cycling events from 1992-2022: Implications for athlete wellbeing and regulatory frameworks
Authors: Smith Alexander , Wijnkoop Moritz van , Colangelo Jill , Buadze Anna , Liebrenz Michael 
Published: February 2023

Abstract

Background: Weight-related issues and adverse weight-management behaviours are prominent concerns in elite-level sports, notably in competitions like men’s road cycling. Whilst other sporting bodies have introduced measures based on Body Mass Index (BMI), no such provision exists in elite-level cycling, which is overseen by the Union Cycliste Internationale (UCI). However, these may be necessary to protect the short- and long-term health of riders and improve perceptions of the sport.
Methods: To ascertain the potential need for targeted policies, we gathered height and weight data from the ProCyclingStats website to investigate BMI trends for the top five male finishers between 1992-2022 in the General Classification (GC) category of the UCI’s Grand Tours: the Giro d’Italia, the Tour de France, and the Vuelta a España.
Results: We calculated the BMI of 156 unique top five finishers in the GC of the Grand Tours with a total of n=445 BMI values (this includes riders who had multiple top five finishes in different races and years). Whilst singular data points varied, we observed overall declining mean BMI trends for these cyclists between 1992-2022.
Conclusion: Our results supplement existing anecdotal and scholarly evidence and suggest that lower BMIs are increasingly associated with top finishing positions in the GC of the men’s Grand Tours. This could have substantial implications for athletes and regulators, since performance pressures could lead to detrimental weight-management practices that can harm short and long-term health and affect the sport’s reputation. Accordingly, we propose that the UCI could consider multifactorial interventions, including prevention and awareness campaigns, screening programs, and BMI-based guidelines.
Formation of amphibole lamellae in mantle pyroxene by fluid-mediated metasomatism: A focal plane array FTIR study from the Carpathian-Pannonian region
Authors: Liptai Nóra , Lange Thomas P. , Patkó Levente , Aradi László E. , Berkesi Márta , Tollan Peter M.E. , Padrón-Navarta José Alberto , Hermann Jörg , Gergely Szilveszter , Szabó Csaba , Kovács István J. 
Published: February 2023

Abstract
Amphiboles in the upper mantle (most frequently pargasitic in composition) have recently gained attention due to their role in the water budget and potential control on the rheology and physical discontinuity of layers of the mantle. Although nominally anhydrous minerals are often analyzed with Fourier transform infrared (FTIR) spectroscopy, amphiboles, especially in natural samples, are only rarely the focus of such studies because of their complex structure and variable composition. In mantle xenoliths, amphibole occurs not only interstitially or forming veins, but also as lamellae within orthopyroxene and/or clinopyroxene grains. The genesis of such lamellae is often ambiguous, as they could either be meta-somatic products, or form by exsolution without an external H2O source upon decreasing P-T conditions and consequent destabilization of hydrous point defects in the host pyroxene. To constrain the origin of amphibole lamellae in pyroxenes, we studied mantle xenoliths from the Carpathian-Pannonian region (CPR) by applying hyperspectral imaging using an FTIR equipped with focal plane array (FPA) detector. Amphibole lamellae are absent in xenoliths of the central part of the CPR, but appear in those from the marginal localities that represent a well-hydrated supra-subduction mantle environment. Some of the lamella-hosting pyroxene grains are in contact with interstitial amphibole, suggesting that the formation of the lamellae is related to the amphibole-producing metasomatism; however, others have no adjacent amphibole. To determine the origin of the amphibole lamellae in pyroxenes without neighboring amphibole, hyperspectral images were used to give an estimation of their volume proportion (0.8–5.1 vol%) in the pyroxenes. Using these volume proportions, we calculated that a bulk water content of ~330–670 (orthopyroxene) and ~740–1430 (clinopyroxene) wt. ppm is needed to be contained in the host grain to be able to facilitate subsolidus exsolution of the observed amount of amphibole lamellae. These water contents are, however, too high for mantle pyroxenes, even for an aqueous-fluid saturated upper mantle. This suggests that the formation of amphibole lamellae is related to a metasomatic event with fluid input from an external water source (e.g., melt/fluid inclusion or metasomatic agent on the grain boundary).
Performance evaluation of buried PVC pipelines for tank irrigation: a case study of Deevanur tank
Authors: Neelmudiyon V. T. , Preethi V. , Govindarajan S. 
Published: February 2023

Abstract
Water is vital to life and development in all parts of the world. Since rain or other precipitation is the only source of water, it should be carefully harvested, stored, conserved and managed for the benefit of the largest number by optimizing the use of the amount available. The available water should be utilized judiciously so that the future generation is saved from deterioration stress. This study was conducted in the Deevanur tank located in Tindivanam Taluk in Tamil Nadu, India. The study was carried out in the crop calendar years from 2006–07 to 2017–18. The performance of the tank irrigation system in this study was evaluated using a Cropping Intensity indicator. This study reveals that Cropping Intensity was increased to more than 100% after rehabilitation of the tank irrigation system and is easily observed. Before rehabilitation of the tank, the average Cropping Intensity value was only 0.87. After rehabilitation of the tank, the average Cropping Intensity value increased to 1.20. The Cropping Intensity indicator is good for evaluating the modernization of the tank irrigation system.
Hydraulic investigation of stilling basins of the barrage before and after remodelling using FLOW-3D
Authors: Zaffar Muhammad Waqas , Hassan Ishtiaq 
Published: February 2023

Abstract
The hydraulic performance of stilling basins is affected by their size and geometry. Taunsa Barrage, Pakistan, was constructed in 1958 and remodelled in 2008. In remodelling, baffle and friction blocks were replaced by chute blocks and dentated sill. After remodelling, sounding, and probing data during 2010–2014 revealed that flexible apron in front of some bays was washed away. This study quantified hydraulic parameters such as free surface, flow depth, Froude number, roller length, velocity, hydraulic jump efficiency, and turbulent kinetic energy for stilling basins before and after remodelling using FLOW-3D. Comparing results with the literature showed that results in the old stilling basin were closer to the literature results. The results of old stilling basin showed linear trends of tailwater depths with Froude number and roller lengths. Results of the new stilling basin deviated from the literature results because relatively weak trends of tailwater depths with the Froude number and roller lengths were revealed; velocities were higher on the basin's floor; energy dissipation was less, and there was more turbulent kinetic energy on downstream. In conclusion, hydraulic studies for other discharges, tailwater levels, and turbulence models have to be conducted to analyze hydraulic issues in the new stilling basin.
Comprehensive management and regulation method of bay ecosystem based on environmental law
Authors: Lin Quanling 
Published: February 2023

ABSTRACT
In order to promote the sustainable development of the gulf ecosystem, a regulation method of the gulf ecosystem based on environmental law was proposed. Taking the coastal bay area of Fujian Province as the research object, based on the analysis of the causes of ecosystem degradation, the energy loss of the area was evaluated from three aspects of climate regulation, waste treatment and interference regulation, and the index weight of integrated ecosystem management was determined to complete the evaluation of the bay ecosystem. The results show that from 2016 to 2020, pollution has increased. The proposed comprehensive management and control methods are adopted to control the pollution index of the region within 0.3, so as to maintain a stable downward trend of pollution.
Microplastics and organics – A comparative study of sorption of triclosan and malachite green onto polyethylene
Authors: Çiftçi Gökçe , Türkeli Ülkü Dide , Özen Elif Yaren , Özdemir Melek , Sanin F. Dilek , İmamoğlu İpek 
Published: February 2023

ABSTRACT

This study aims to elucidate interaction of organics with microplastics in a comparative manner via the use of two model compounds (i.e., triclosan (TCS) and malachite green (MG)) having different physicochemical properties, onto polyethylene (PE). TCS, is hydrophobic with low solubility, while MG is hydrophilic with high aqueous solubility. Kinetic studies indicate faster sorption (teq = 24 h) and equilibrium studies show much higher capacity (qe = 6,921 μg/g) for TCS, when compared to those of MG (teq = 5 d, qe = 221 μg/g). While pseudo-kinetic model fits sorption of both organics to PE, equilibrium isotherms as well as the results on effect of particle size and pH indicate dissimilar sorption mechanisms. Considering pHPZC = 2, observation of favourable sorption of TCS in acidic regions and sorption being unaffected by particle size was explained by TCS sorption to be dominated by hydrophobic interactions in amorph regions of PE. Higher removal of MG was observed at lower surface charge of PE, and a clear favourable impact of surface area on MG sorptive capacity pointed to the presence of non-specific van der Waals type interactions on the surface of PE. Mechanistic evaluations presented here contribute to our understanding of interaction of MPs with organics in aquatic ecosystems.
Integration of ozonation with water treatment for pharmaceuticals removal from Arroio Diluvio in southern Brazil
Authors: Costa Letícia Reggiane de Carvalho , Féris Liliana Amaral 
Published: February 2023

AbstractPharmaceutical compounds can reach water bodies through sewage systems. The process of water treatment is insufficient for the removal of these contaminants. The ozonation has great potential to be integrated into the treatment, since it promotes the reduction of pharmaceuticals, reduces the generation of disinfection byproducts and can reduce operational costs. In this work, the integration of the ozonation process with water treatment was studied. The ozone was applied in the pre-oxidation and intermediate ozonation stages, to evaluate the dependence of different variables. Water samples were collected from Arroio Diluvio, a river of the city of Porto Alegre (Brazil). The doses of ozone were maintained between 0.5 and 1.0 mgO3 L−1 while the coagulant was between 25 and 150 mg·L−1. Pre-ozonation resulted in a removal of pharmaceuticals at pH 10.0, time of 15 min and coagulant concentration of 52.5 mgL−1. The intermediate ozonation provided a removal with pH 10.0 and a time of 5 min of bubbling. Based on the results, it was confirmed that the synergy of the ozonation process with conventional water treatment is an effective, sensitive and fast method for the removal of pharmaceuticals from the aqueous medium.
Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance
Authors: Zhou Fengqiang , Qi Yanmei , Geng Zhen , Ding Baozhong , Liu Lei 
Published: February 2023

Aims:
The present study investigated the exact proportion, the extent of in vitro proliferation potential, and oxaliplatin chemoresistance of EpCAMhigh/CD44+ cancer stem cells in colorectal cancer. Its underlying mechanism was also explored.

Background:
Colorectal cancer stem cells (CSC) play crucial roles in tumorigenicity and chemoresistance. Multiple studies have shown that JAK/STAT, NOTCH, and Wnt/-catenin pathways, associated with tumour recurrence and metastasis, contribute to the proliferation and maintenance of CSCs. CSCs become resistant to chemo-radiotherapies by improving DNA damage repair, changing cell cycle checkpoints, and scavenging reactive oxygen species, resulting in a bad patient prognosis.

Objective:
This work was carried out to determine the precise fraction, the degree of in vitro proliferation capability, and the level of oxaliplatin chemoresistance exhibited by EpCAMhigh/CD44+ cancer stem cells in colorectal cancer. The research was also done to investigate its underlying process.

Methods:
Fluorescence-activated cell sorting (FACS) was applied to isolate the EpCAMhigh/CD44+ populations from three human colorectal cancer cell lines (HCT116, HT29, and LoVo), and we quantified the average proportion of the EpCAMhigh/CD44+ cells in every cell lines. The comparison of their proliferation ability and the chemoresistance to oxaliplatin with the parental cells was estimated by CCK8 assay. The activated signaling pathway was tested by Western Blotting.

result:
EpCAMhigh/CD44+ subpopulation comprise about 4.98±1.24% of the total human colorectal cancer cell lines, and the EpCAMhigh/CD44+ cells exhibited a highly better proliferation ability and stronger oxaliplatin chemoresistance than the parental cells. Wnt/β-catenin signaling pathway is activated in EpCAMhigh/CD44+ HCT116 cells.

Results:
EpCAMhigh/CD44+ subpopulation comprises about 4.98±1.24% of the total human colorectal cancer cell lines, and the EpCAMhigh/CD44+ cells exhibited a highly better proliferation ability and stronger oxaliplatin chemoresistance than the parental cells. The wnt/β-catenin signaling pathway is activated in EpCAMhigh/CD44+ HCT116 cells

conclusion:
Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance.

Conclusion:
Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance.
Comparison of the Effect of Honey, Olive, Propolis Combined Vaginal Cream With OCP in the Treatment of Functional Ovarian Cysts in Women of Reproductive Age Referring to Health Centers, Hamadan, Iran 2020-2021
Authors: Shayan Arezoo , Parsapour Hamideh , Hosseinpoor Mehrnoosh , Masoumi Seyedeh Zahra , Kazemi Farideh , Moradkhani Shirin , Hossein Oliaei Seyed Mohammad , Assareh Zeinab , Rashidi Mohammad Kazem 
Published: February 2023

Background:The prevalence of functional ovarian cysts in women is high, and choosing an appropriate, and uncomplicated treatment is necessary.Objective:Compare the effectiveness of honey, olive, and propolis combined vaginal cream with OCP in the treatment of functional ovarian cysts in women of reproductive age in Iran.Methods:This randomized clinical trial study was performed on 40 women of reproductive age referred to Hamadan health centers in 2020. Patients were randomized into two groups, A and B. Group A received oral contraception pills for two consecutive cycles from the seventh day of the menstrual cycle tablets for 21 days after the end of menstruation until the beginning of the next menstruation. Group B received honey, olive, propolis combined vaginal cream. In both groups, the treatment continued for two consecutive cycles. Data was collected through a checklist that included clinical symptoms and ultrasound results. The results were analyzed by Stata-13 and the significance level cut-off was considered less than 0.05.Results:Intra-group comparisons showed that there was a statistically significant (P < 0.05) decrease in cyst size after the intervention in both groups. Intergroup differences were not statistically significant (P ˃ 0.05).Conclusion:Honey, olive, propolis combined vaginal cream (Nika) can be effective like oral contraceptive pills in reducing the size of ovarian cysts. It can be recommended for the treatment of functional ovarian cysts.Clinical Trial Registration Number:IRCT20120215009014N384
Virtual Screening and Multi-targets Investigation of Novel Diazine Derivatives
as Potential Xanthine Oxidase Inhibitors Based on QSAR, Molecular
Docking, ADMET Properties, Dynamics Simulation and Network
Pharmacology
Authors: Yi Bingxiang , Sun Jiaying , Liu Yaru , Zhang Zhiping , Wang Rui , Shu Mao , Lin Zhihua 
Published: February 2023

Background:
Hyperuricemia is closely related to the occurrence of gout, hypertension,
diabetes, hyperlipidemia, cardiovascular disease, kidney disease, metabolic syndrome, etc. However,
xanthine oxidase inhibitors (XOIs) can fundamentally solve the problem of excessive uric acid.
Compared to single-target drugs, multi-target drugs are not prone to adverse reactions and exert a
synergistic effect. Therefore, the discovery of new multi-target XOIs and their mechanism of therapeutic
hyperuricemia are important to overcome adverse effects and resistance to currently available
drugs.

Objective:
The purpose of this paper is to obtain novel diazine derivatives as promising multi-target
XOIs and discover the interaction mechanism for the better treatment of hyperuricemia.

Methods:
Novel multi-target XOIs diazine derivatives, and their interaction mechanism have been
obtained through QSAR, molecular docking, dynamics simulation, and network pharmacology. In
addition, ADMET properties and synthetic accessibility of novel XOIs have been considered using
ADMETLAB 2.0 and SwissADME.

Results:
24 novel diazine derivatives as potential multi-target XOIs lead compounds have been
found through virtual screening of the PubChem database. Moreover, the most notable top five compounds
are worthy of further developing as multi-target XOIs drugs. XDH, TBK1, DGAT1, MYC,
CDKN1A, PPARD, PDE6C, and EIF4E are recommended as relevant targets of therapeutic hyperuricemia.

Conclusion:
Through the combination of different methods, we have discovered five novel promising
diazine derivatives as potential multi-target XOIs drugs. Meanwhile, eight targets have been
found to be helpful in the research on therapeutic hyperuricemia. We expect this investigation will
offer clear insights into the production of efficient XOIs drugs.
The ABCB1 C3435T Polymorphism is Associated with Triglyceride Reduction
in Atorvastatin-treated Uygur Patients with Coronary Heart Disease
and Dyslipidemia: An Observational Study
Authors: Li Hongjian , Yu Luhai , Wang Tingting , Wu Jianhua , Liu Tingting , Xu Li , Feng Jie , Zhang Huilan , Shen Hao , Sun Li 
Published: February 2023

Background:
The morbidity of coronary heart disease (CHD) and dyslipidemia in the Uygur
population of Xinjiang is higher than the national average. Interindividual variability of the response to
atorvastatin is a major clinical problem; generally, statins shed less impressive benefits for females than
males. Nevertheless, it is unclear whether ABCB1 genes and sex modify the efficacy of atorvastatin in
Uygur patients.

Objective:
To determine the impact of ABCB1 gene polymorphisms on the therapeutic response to
atorvastatin in a Uygur population with dyslipidemia.

Methods:
Patients with dyslipidemia were treated with 20 mg/d or 40 mg/d atorvastatin for two to six
months. TC, LDL-C, HDL-C, TG, APOB, APOE, LP(a), and APOA1 levels were measured before and
after atorvastatin administration. We performed genotyping of ABCB1 C3435T and G2677T variants using
hybridization sequencing. The association of variants between the percentage of change in TG levels
was examined using multiple linear regression analysis.

Results:
We enrolled 193 Uygur patients. Atorvastatin reduced TG, LDL-C, TC, APOB, and APOE levels
(P < 0.05), whereas LP(a) and APOA1 levels increased (P < 0.05). In multiple linear regression analysis,
baseline TG level (beta 0.204; 95% confidence interval (CI): 1.980–10.493; P = 0.004) and TT genotype
of ABCB1 C3435T (beta 0.162; 95% CI: 2.517–23.406; P = 0.023) predicted TG reduction with atorvastatin
therapy in overall patients. Baseline TG level (beta 0.346; 95% CI: 4.374 -13.34; P < 0.001) with the
TT genotype of ABCB1 C3435T (beta 0.401; 95% CI: 4.053–28.356; P = 0.021) was associated with a
significant reduction in TG levels in men. Only baseline TG level predicted TG reduction within six
months of atorvastatin therapy for females (beta 0.61; 95% CI: 3.204–20.557; P = 0.041).

Conclusions:
In patients with the ABCB1 C3435T TT genotype, atorvastatin more effectively lowered TG
than other polymorphisms. This investigation may provide insights into effective individualized therapies
for CHD and dyslipidemia in the Uygur population.