bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis
Authors: Salari Nader , Sadeghi Narges , Hosseinian-Far Amin , Hasheminezhad Razie , Khazaie Habibolah , Shohaimi Shamarina , Mohammadi Masoud 
Published: July 2023

Abstract
Background
Ankylosing Spondylitis (AS) patients face several challenges due to the nature of the disease and its physical and psychological complications. Sleep disorders are among the most important concerns. Sleep disorders can aggravate the signs and symptoms of the disease and ultimately reduce the quality of patients’ lives. This study uses a systematic review and meta-analysis to pool the reported prevalence of sleep disorders among AS patients.

Methods
To find related studies, the WoS, PubMed, ScienceDirect, Scopus, Embase, and Google Scholar databases were systematically searched without a lower time limit. Heterogeneity among the identified studies was checked using the I2 index, and the Begg and Mazumdar correlation test examined the existence of published bias. Comprehensive Meta-Analysis (v.2) software was adopted to analyze the data.

Results
In the review of 18 studies with a sample size of 5,840, the overall pooled prevalence of sleep disorders among AS patients based on the random effects method was found to be 53% (95% CI: 44.9–61). The highest and lowest prevalence was in Egypt at 90% and Australia at 19.2%, respectively. Our meta-regression results show that with the increase in ‘sample size’ and ‘year of publication’, the overall prevalence of sleep disorders in patients with AS decreases (p < 0.05).

Conclusion
The results of the present study indicate a high and significant prevalence of sleep disorders among AS patients. Thus, health policymakers and healthcare providers must focus on timely diagnosis and effective educational and therapeutic interventions for the prevention and proper treatment of sleep disorders in this population of patients.
Malaria prevalence in Commune 5 in Tumaco (Nariño, Colombia)
Authors: Chaparro Narváez Pablo Enrique , Jimenez-Serna Monica Marcela , Gunturiz Albarracin Maria Luz , Carrasquilla Gutierrez Gabriel 
Published: July 2023

AntecedentesLa malaria urbana es un problema de salud pública en Colombia y aún existe desconocimiento sobre sus características epidemiológicas, las cuales son clave para la implementación de medidas de control. La presencia de casos de malaria urbana y el diagnóstico de la enfermedad son algunos de los desafíos que enfrentan los programas de eliminación de la malaria. El objetivo de esta investigación fue estimar la prevalencia de malaria, explorar factores asociados y detectar genespfhrp2/3, en la zona urbana de Tumaco entre julio y diciembre de 2019.MétodosSe realizó un estudio de prevalencia utilizando un muestreo probabilístico aleatorio estratificado. Se administraron encuestas estructuradas y se tomaron muestras de sangre y se examinaron mediante microscopía óptica, pruebas de diagnóstico rápido (RDT) y reacción en cadena de la polimerasa (PCR). Se utilizó un modelo de regresión logística para explorar los factores asociados.ResultadosSe encuestó a 1.504 personas que vivían en 526 hogares. La prevalencia global fue del 2,97% (IC 95%: 2,1 - 4,3%). Fue mayor en varones, en el grupo de edad de 10 a 19 años y en casos asintomáticos. La prevalencia de la amplificación depfhrp2fue del 2,16 % (IC del 95 %: 1,6 - 2,9 %). Los hogares con tres o más personas tenían un mayor riesgo de infección por paludismo (odds ratio ajustado [ORa] 4,05; intervalo de confianza [IC] del 95%: 1,57-10,43). Todos los casos se debieron aP.falciparum.ConclusionesLa prevalencia de malaria urbana fue baja. Las estrategias para eliminar la malaria en áreas urbanas deben ajustarse considerando el acceso al diagnóstico temprano, la infección asintomática y las PDR utilizadas para detectar la presencia del genpfhrp2.
Understanding the use of peers for mental health care: A meta-synthesis of qualitative evidence
Authors: Ahmad Ikhlaq , Hanif Mubashir , Waqas Ahmed , Suleman Nadia , Atif Najia , bibi Amina , Zulfiqar Shafaq , Kayani Shoaib Sultan , Khan Shahzad Ali , Khan Aasia , Sikander Siham 
Published: July 2023

Objective: We aim to synthesize evidence of facilitators and barriers pertaining to implementation of peer led interventions for mental health. Methods: In November 2017, we conducted an electronic search of two academic databases: Cochrane Central Register of Controlled Trials (CENTRAL) and PubMed. A comprehensive search strategy comprising of search terms including ‘peer’, ‘volunteer’, ‘Mental Health’, and ‘Qualitative Study’ was utilized to search these databases. Results: A total of six studies were included in this review. We have identified 22 first order constructs in the selected studies. These are all responses of the respondents in each individual study. Key constructs are recruitment and training, supervision, role of Peer Support Workers (PSWs), motivation, challenges and barriers. Second order constructs are researchers’ interpretations of included studies. Conclusions: We identified 26 second order constructs. These constructs are very similar to first order constructs and grouped under similar themes that were used for first order constructs. Additional constructs included insufficient training, uniformity of training, terms and conditions for PSWs.
E-learning modules to improve clinical reasoning and practice: a prospective comparative study
Authors: Stollar Fabiola , Cerutti Bernard , Aujesky Susanne , Scherly Daniel , Nendaz Mathieu , Galetto-Lacour Annick 
Published: July 2023

Background:Controversy remains about whether e-learning can improve clinical competences. Our study aimed to compare the effects of e-learning versus traditional education on medical students' reasoning and how they applied their knowledge to clinical competences, assess factors associated with e-learning that might influence exam scores, and evaluate medical students' satisfaction with these two learning methods.Methods:Prospective study of 299 medical students in two fourth-year pediatric clerkship cohorts (2016–17 and 2017–18) in Switzerland.Results:We found no evidence of a difference in students' reasoning or how they applied their knowledge to competences in clinical case resolution, whether they had followed e-learning modules or attended traditional lectures. The number of quizzes taken and being female were factors associated with better scores. Even though overall satisfaction with the two learning methods was similar, students claimed that they learned more in e-learning than in traditional lectures and that e-learning explained learning objectives better.Conclusions:E-learning could be used as a supplement or alternative to traditional face-to-face medical teaching methods without compromising teaching quality. E-learning modules should be better integrated into medical students' curricula but avoid the risk of curriculum overload, especially in case of repeated COVID-like context.
Study protocol: A cross-sectional survey of clinicians to identify barriers to clinical practice guideline implementation in the assessment and treatment of persistent tic disorders
Authors: Martindale Jaclyn M. , Sarva Harini , Martino Davide , Gilbert Donald L. , Ganos Christos , Pringsheim Tamara , Black Kevin , Malaty Irene A. ,   all on behalf of the Movement Disorder Society Tic and Tourette Study Group
Published: July 2023

IntroductionEight members of the International Parkinson’s Disease and Movement Disorders Society Tic and Tourette Syndrome Study Group formed a subcommittee to discuss further barriers to practice guideline implementation. Based on expert opinion and literature review, the consensus was that practice variations continue to be quite broad and that many barriers in different clinical settings might negatively influence the adoption of the American Academy of Neurology and the European Society for the Study of Tourette Syndrome published guidelines.Objectives1) To identify how clinical practices diverge from the existing American Academy of Neurology and European Society for the Study of Tourette Syndrome guidelines, and 2) to identify categories of barriers leading to these clinical care gaps.Methods and analysisThis article presents the methodology of a planned cross-sectional survey amongst healthcare professionals routinely involved in the clinical care of patients with persistent tic disorders, aimed at 1) identifying how practices diverge from the published guidelines; and 2) identifying categories of barriers leading to these clinical care gaps. Purposeful sampling methods are used to identify and recruit critical persistent tic disorders stakeholders. The analysis will use descriptive statistics.
The existence and uniqueness of solutions to a functional equation arising in psychological learning theory
Authors: Turab Ali , Rosli Norhayati , Ali Wajahat , Nieto Juan J. 
Published: July 2023

Abstract
The paradigm of choice practice represents the psychological theory of learning in the development of moral judgment. It is concerned with evaluating the implications of several choices and selecting one of them to implement. The goal of this work is to provide a generic functional equation to observe the behavior of animals in such circumstances. Our suggested functional equation can be employed to describe several well-known psychology and learning theories. The fixed point theorem proposed by Banach is utilized to show that the solution of a given functional problem exists and is unique. In addition, the stability of the given functional equation’s solution is discussed in terms of the Hyers-Ulam and Hyers-Ulam-Rassias results. Furthermore, two examples are provided to highlight the relevance of the significant outcomes in the context of the literature.
Validation of machine learning ridge regression models using Monte Carlo, bootstrap, and variations in cross-validation
Authors: Nakatsu Robbie T. 
Published: July 2023

Abstract
In recent years, there have been several calls by practitioners of machine learning to provide more guidelines on how to use its methods and techniques. For example, the current literature on resampling methods is confusing and sometimes contradictory; worse, there are sometimes no practical guidelines offered at all. To address this shortcoming, a simulation study was conducted that evaluated ridge regression models fitted on five real-world datasets. The study compared the performance of four resampling methods, namely, Monte Carlo resampling, bootstrap, k-fold cross-validation, and repeated k-fold cross-validation. The goal was to find the best-fitting λ (regularization) parameter that would minimize mean squared error, by using nine variations of these resampling methods. For each of the nine resampling variations, 1,000 runs were performed to see how often a good fit, average fit, and poor fit λ value would be chosen. The resampling method that chose good fit values the greatest number of times was deemed the best method. Based on the results of the investigation, three general recommendations are made: (1) repeated k-fold cross-validation is the best method to select as a general-purpose resampling method; (2) k = 10 folds is a good choice in k-fold cross-validation; (3) Monte Carlo and bootstrap are underperformers, so they are not recommended as general-purpose resampling methods. At the same time, no resampling method was found to be uniformly better than the others.
Quercetin induces cytotoxicity and apoptosis, reduces metastasis and drug resistance in oral cancer cells
Authors: Li Nan , Wang Jun 
Published: July 2023

Abstract
Quercetin is a plant flavonol from the flavonoid group of polyphenols or can also be formulated as a synthetic supplement chemically. Approximately 80 % of people in Africa and other developing nations still depend on traditional herbal remedies to treat ailments. Quercetin has been demonstrated to have a variety of anticancer effects. However, the effect of quercetin on oral cancer cells remains rare. According to our systematic review, quercetin includes anti-cell viability, anti-cell survival and anti-cell proliferation. Quercetin also possesses an anti-metastatic effect by regulating the expression of epithelial-to-mesenchymal transition-related genes in oral cancer cells. The apoptotic effect of quercetin in oral cancer cells is probably via inducing cell surface death receptors, endoplasmic reticulum stress and mitochondria-mediated signaling pathways. Additionally, quercetin reduces drug resistance in KB/vincristine oral cancer cells and enhances cell sensitivity to vincristine treatment. Quercetin induces apoptosis of human oral cancer SAS cells through the endoplasmic reticulum and mitochondria-mediated signaling pathways. Quercetin inhibits cell survival and metastatic ability via the epithelial-to-mesenchymal transition-mediated signaling pathways in oral squamous cell carcinoma. Quercetin is an anti-tumour agent candidate and can also inhibit oral tumour metastasis. Indeed, the efficacy of quercetin against chemically induced oral squamous cell carcinoma remains to be elucidated.
GÊNERO, DIREITO E CUIDADO
Authors: Anabelle Santos Lages  , Débora Allebrandt  , Raphaela Alencar Calheiros  
Published: July 2023

Este artigo se propõe a analisar dados coletados a partir de uma pesquisa com orientação etnográfca de audiências que envolviam, estabeleciam e revisavam a guarda de crianças e adolescentes em uma Vara de Família na cidade de Maceió – AL. Nessa vara, cuja maioria absoluta do corpo técnico e representantes do Ministério Público e Defensoria são mulheres, debatemos concepções de “lugar de mulher”, “essência do feminino” e sua “sensibilidade” para tratar temas de família. Nas audiências, através da tentativa de implementação da guarda compartilhada, acompanhamos negociações do que seria a “paternidade responsável” a partir da persistência de um modelo nuclear de família. Abordamos a inserção gradual de mulheres no direito e como as decisões tomadas na vara são desafadas por estereótipos sobre mulheres e suas competências, questionando quem tem direito a exigir a paternidade com responsabilidade. Os casos narrados demonstram os desafos e tensões para a implementação da guarda compartilhada e como noçõeshegemônicas de gênero e cuidado se tornam um obstáculo para ampliação doexercício da parentalidade.
The pinnacle of S. S. Zimnitsky scientific work — nephrology research
Authors: Оslopov V. N. , Khazova E. V. , Khasanov N. R. , Oslopova Yu. V. , Mishanina Yu. S. , Oslopova D. V. 
Published: July 2023

The pinnacle of S. S. Zimnitsky scientific heritage is the Zimnitsky, which makes it possible to assess the renal function without invasive procedures and burdening the patient. Proposed a hundred years ago, the Zimnitsky test shows its effectiveness at the present time. S. S. Zimnitsky proposed an original classification of hydronephrosis, described a special form of nephritis and rejected the filtration theory of urine formation, promoting the secretory one. In his purely scientific nephrological articles, S. S. Zimnitsky acts as a sincere and ardent patriot of his great homeland.
Emotional competencies as a factor in maintaining the mental health of medical workers
Authors: Plugina M. I. 
Published: July 2023

Aim. To study the protective role of emotional competencies (ECs) in maintaining the mental health of medical workers.Material and methods. The sample consisted of 170 medical workers. Methods for assessing the level of emotional burnout and empathic abilities by V. V. Boyko, emotional intelligence by D. V. Lyusin, the style of behavior self-regulation by V. I. Morosanova, the differential type of reflection by D. A. Leontiev, the neuroticism by K. K. Yakhin, D. M. Mendelevich. The following statistical methods were used: correlation analysis (Pearson r-test), hierarchical factor analysis.Results. Reliable two-way correlations were determined between a wide range of individual symptoms of emotional burnout and neuroticism, which are manifestations of mental illness, and the characteristics of the emotional intelligence of medical workers. Based on factor analysis of self-regulation parameters, empathy, reflection and emotional intelligence, 4 ECs were identified: intrapersonal areflexive Ego-centered, intrapersonal infantile, regulative, intrapersonal reflexive. We determined that in mentally healthy medical workers, the regulative ECs are most pronounced. Employees with the early stage mental illness simultaneously present intrapersonal ECs that are multidirectional in terms of reflexivity (areflexive Ego-centered and reflexive). Mentally unhealthy medical workers were found to be unformed in all ECs.Conclusion. The positive relationships identified in the study between regulative mature intrapersonal and interpersonal ECs and a favorable mental health of medical workers suggest the need to develop training programs for ECs as a factor in maintaining the mental health of medical workers.
Chronic hypoparathyroidism: clinical manifestations, complications and impact on the quality of life
Authors: Kovaleva E. V. , Eremkina A. K. , Mokrysheva N. G. 
Published: July 2023

Hypoparathyroidism is a relatively rare endocrine disorder caused by the absence production of parathyroid hormone, leading to the classical biochemical features such as hypocalcaemia and hyperphosphataemia.The data from Europe, the USA and Asian countries shows that the long course of chronic postsurgical and non-surgical hypoparathyroidism can lead to many complications from different organs and systems. Hypoparathyroidism increases the risk of kidney disease, including kidney failure, neuropsychiatric disorders and infections. The frequency and degree of disease complications depend on its etiology. Non-surgical hypoparathyroidism is associated with an increased risks of cataracts, cardiovascular diseases and vertebral fractures; however, the pathogenesis of these disorders is not fully understood. Various parameters of mineral homeostasis were discussed in the context of identified complications. For example, persistent hypercalciuria and intake of large doses of calcium and vitamin D supplements were associated with the structural pathology of the kidneys (nephrolithiasis, nephrocalcinosis).This review covers the issue of the clinical manifestations and complications of chronic hypoparathyroidism, as well as predictors of their development.
Some aspects of diagnosis, course and prediction of outcomes of a new coronavirus infection in patients with diabetes mellitus
Authors: Volynkina A. P. , Khodarina Yu. V. , Kazakova P. I. , Volynkina E. A. , Naumova N. V. , Elizarova I. O. 
Published: July 2023

Introduction. By 2023 it has been detected more than 600 million cases of COVID-19. One of the most significant risk factors for the severe course of a new coronavirus infection (NCVI) is the presence of comorbid diseases, especially the presence of diabetes mellitus (DM).Aim. To investigate the laboratory and clinical features of a new coronavirus infection in people with diabetes mellitus, to identify predictors of an adverse outcome of COVID-19.Material and methods. We carried out data from medical records of 248 patients treated in “Voronezh Clinical Emergency Hospital № 10” in the departments “COVID-5” and “COVID-8”. Data collection and statistical processing were performed with Microsoft Excel 10.0 and StatSoft STATISTICA 12.0 programs.Results. The most frequent complaints of patients were general weakness, hyperthermia and dry cough. The analysis of the age characteristics revealed that the peak incidence of NCVI in hospitalized patients without DM falls on 70-79 years, with concomitant DM — on 60-69 years.Among comorbid pathologies, hypertension, coronary heart disease and chronic heart failure prevailed. The presence of these diseases is a predictor of adverse outcomes in NCVI, along with cerebrovascular diseases and anemia.Evaluation of laboratory data revealed the link of elevated levels of ferritin, C-reactive protein and D-dimer with an increased risk of death of NCVI.Conclusion. Estimation the risk factors of a fatal outcome is crucial for the choice of patient treatment tactics.
The Lower - Middle Miocene transition (Karpatian – Badenian) in the Krems Embayment (Central Paratethys, Lower Austria): a multistrati-graphic approach and the role of the Diendorf-Boskovice Fault System.
Authors: Gebhardt Holger , Schenk Bettina , Enge Annekatrin , Ćorić Stjepan , Ranftl Eva-Maria , Heinz Petra 
Published: July 2023

Abstract
The Krems Embayment contains the westernmost fully marine depositional environments of the Karpatian and Bade-nian transgressions in the Central Paratethys. Four drill cores were investigated to analyse the bio- and lithostratigraphic, and tectonic relations. The investigated core sections cover the Karpatian Laa Formation (bio-zones M4, NN4) and the Badenian Gaindorf Formation (M5b-M6, NN4-NN5). Important biostratigraphic indicators identified are Praeorbulina glomerosa glomerosa, Praeorbulina glomerosa circularis and Orbulina suturalis for the Gaindorf Formation. The Laa Formation is indicated by the absence of Praeorbulina, Orbulina and Globigerina falconensis, low numbers of Globorotalia bykovae, and a prominent peak in Helicosphaera ampliaperta abundance at the end of the Karpatian. Cibicidoides lopjanicus and Cassigerinella spp. occur with high percentages in Badenian samples and show much longer stratigraphic ranges than known from literature data. The depositional gap at the Karpatian-Badenian boundary has a minimum duration of 0.41 My in the Krems Embayment. The combination of bio- and lithostratigraphic data allows the correlation across major faults. The Diendorf-Boskovice Fault System played an important role during basin formation and was identified as very active during the early to middle Badenian Stage. The results of this study show the complex interaction of sedimentation, tectonic activity and paleobiological developments in this peripheral part of a marginal sea.
The Prevalence of Exposure to Violence Among Healthcare Professionals in Adana and Their Opinion on Violence in Health
Authors: Yılmaz Kemal , Kaya Kenan , Özesen Toygün Anıl , Hilal Ahmet 
Published: July 2023

Objective: Workplace violence is an important source of problem for employees worldwide. The present study aimed to identify the prevalence of exposure to violence among healthcare professionals, the type of violence they experienced and influencing occupational features, and to determine the healthcare professionals’ opinion about the causes of violence and the potential measures to be taken against violence in health.
Methods: A 37-question survey was performed in 598 medical doctors and 357 healthcare assistants including nurses as well in Adana, Türkiye.
Results: Of the 955 healthcare professionals participated in the study, 48.5% were male and 51.5% were female, and 85.9% have been subjected to violence at least once in their professional lifetime. The most common type of violence was psychological or verbal attack, which stated to be most frequently committed by the patient relatives and by male gender. Male healthcare workers were exposed to statistically significantly more physical violence. There was statistically significant correlation between the number of patients healthcare professionals dealt with in a day and the rate of exposure to violence. It was found that those who had been exposed to physical violence filed a complaint more than those who had been subjected to other forms of violence.
Conclusion: High rates of violent behaviour against healthcare workers are at worrying levels indicating that violence in health is a critical problem. Solution of this problem requires all parties’, primarily the health policy makers’ undertaking important tasks.