bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a collaborative cloud platform to accelerate heart, lung, blood, and sleep research
Authors: Ahalt Stan , Avillach Paul , Boyles Rebecca , Bradford Kira , Cox Steven , Davis-Dusenbery Brandi , Grossman Robert L , Krishnamurthy Ashok , Manning Alisa , Paten Benedict , Philippakis Anthony , Borecki Ingrid , Chen Shu Hui , Kaltman Jon , Ladwa Sweta , Schwartz Chip , Thomson Alastair , Davis Sarah , Leaf Alison , Lyons Jessica , Sheets Elizabeth , Bis Joshua C , Conomos Matthew , Culotti Alessandro , Desain Thomas , Digiovanna Jack , Domazet Milan , Gogarten Stephanie , Gutierrez-Sacristan Alba , Harris Tim , Heavner Ben , Jain Deepti , O'Connor Brian , Osborn Kevin , Pillion Danielle , Pleiness Jacob , Rice Ken , Rupp Garrett , Serret-Larmande Arnaud , Smith Albert , Stedman Jason P , Stilp Adrienne , Barsanti Teresa , Cheadle John , Erdmann Christopher , Farlow Brandy , Gartland-Gray Allie , Hayes Julie , Hiles Hannah , Kerr Paul , Lenhardt Chris , Madden Tom , Mieczkowska Joanna O , Miller Amanda , Patton Patrick , Rathbun Marcie , Suber Stephanie , Asare Joe 
Published: May 2023

Abstract
Research increasingly relies on interrogating large-scale data resources. The NIH National Heart, Lung, and Blood Institute developed the NHLBI BioData CatalystⓇ (BDC), a community-driven ecosystem where researchers, including bench and clinical scientists, statisticians, and algorithm developers, find, access, share, store, and compute on large-scale datasets. This ecosystem provides secure, cloud-based workspaces, user authentication and authorization, search, tools and workflows, applications, and new innovative features to address community needs, including exploratory data analysis, genomic and imaging tools, tools for reproducibility, and improved interoperability with other NIH data science platforms. BDC offers straightforward access to large-scale datasets and computational resources that support precision medicine for heart, lung, blood, and sleep conditions, leveraging separately developed and managed platforms to maximize flexibility based on researcher needs, expertise, and backgrounds. Through the NHLBI BioData Catalyst Fellows Program, BDC facilitates scientific discoveries and technological advances. BDC also facilitated accelerated research on the coronavirus disease-2019 (COVID-19) pandemic.
Exploring the role of structuralist methodology in the neuroscience of consciousness: a defense and analysis
Authors: Kob Lukas 
Published: May 2023

AbstractTraditional contrastive analysis has been the foundation of consciousness science, but its limitations due to the lack of a reliable method for measuring states of consciousness have prompted the exploration of alternative approaches. Structuralist theories have gained attention as an alternative that focuses on the structural properties of phenomenal experience and seeks to identify their neural encoding via structural similarities between quality spaces and neural state spaces. However, the intertwining of philosophical assumptions about structuralism and structuralist methodology may pose a challenge to those who are skeptical of the former. In this paper, I offer an analysis and defense of structuralism as a methodological approach in consciousness science, which is partly independent of structuralist assumptions on the nature of consciousness. By doing so, I aim to make structuralist methodology more accessible to a broader scientific and philosophical audience. I situate methodological structuralism in the context of questions concerning mental representation, psychophysical measurement, holism, and functional relevance of neural processes. At last, I analyze the relationship between the structural approach and the distinction between conscious and unconscious states.
Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2
Authors: Tian Ning , Huang Zhe , Jang Bo Gyu , Guo Shuaifei , Yan Ya-Jun , Gao Jingjing , Yu Yijun , Hwang Jinwoong , Tang Cenyao , Wang Meixiao , Luo Xuan , Sun Yu Ping , Liu Zhongkai , Feng Dong-Lai , Chen Xianhui , Mo Sung-Kwan , Kim Minjae , Son Young-Woo , Shen Dawei , Ruan Wei , Zhang Yuanbo 
Published: May 2023

Abstract
Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional superconductivity. The dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2 that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality, however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating state. The dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.
Vitamin D levels and the risk of overactive bladder: a systematic review and meta-analysis
Authors: Zhang Qiang , Zhang Zhicheng , He Xueyu , Liu Zhenmin , Shen Lianju , Long Chunlan , Wei Guanghui , Liu Xing , Guo Chunming 
Published: May 2023

Abstract

Context
Overactive bladder is treated mainly with behavioral and drug therapy, and symptoms of urinary frequency and incontinence are challenging to eliminate. There is thus a continuous unmet need for new drugs with a substitution effect mechanism.

Objective
It not known whether vitamin D deficiency can lead to overactive bladder or urinary incontinence or whether vitamin D supplementation alleviates bladder symptoms. This comprehensive systematic review with meta-analysis was conducted to determine whether overactive bladder is associated with vitamin D deficiency.

Data Sources
The PubMed and Cochrane Library databases were searched systematically up to July 3, 2022.

Data Extraction
Initially, 706 articles were identified in the literature search, of which 13 were included in the systematic review: 4 randomized controlled trials, 3 cohort studies, 3 cross-sectional studies, and 3 case-control studies.

Data Analysis
An increased risk of overactive bladder and urinary incontinence was observed with vitamin D deficiency (odds ratio [OR] = 4.46; 95%CI, 1.03–19.33; P = 0.046 and OR = 1.30; 95%CI, 1.01–1.66; P = 0.036, respectively). Vitamin D levels were relatively low in patients with overactive bladder or urinary incontinence (SMD = −0.33; 95%CI, −0.61 to −0.06, P = 0.019). On the basis of existing data, the risk of urinary incontinence was reduced by 66% after vitamin D supplementation (OR = 0.34; 95%CI, 0.18–0.66; P = 0.001). Egger test was conducted to assess publication bias, and the results were tested for robustness using a sensitivity analysis.

Conclusions
Vitamin D deficiency increases the risk of overactive bladder and urinary incontinence, and vitamin D supplementation reduces the risk of urinary incontinence. The development of new strategies to prevent or alleviate bladder symptoms is crucial. Vitamin D supplementation may be gaining recognition as an effective strategy for prevention or alleviation of bladder symptoms such as overactive bladder and incontinence.

Systematic Review Registration
PROSPERO registration no. CRD42022351443.
An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam Resistance
Authors: Simner Patricia J , Bergman Yehudit , Conzemius Rick , Jacobs Emily , Tekle Tsigereda , Beisken Stephan , Tamma Pranita D 
Published: May 2023

Abstract

Background
Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are preferred treatment regimens for New Delhi metallo-β-lactamase (NDM)-producing infections.

Methods
We report the case of a US patient who traveled to India to receive a renal transplant. He subsequently experienced pyelonephritis by an NDM-producing Escherichia coli. Broth microdilution and the broth disk elution method indicated resistance to all β-lactams, including cefiderocol and CZA-ATM. Whole-genome sequencing investigations were undertaken to identify resistance mechanisms.

Results
An E. coli isolate belonging to sequence type (ST) 167 containing a blaNDM-5 gene was identified on a plasmid of the IncFIA/IncFIB/IncFIC replicon groups. When compared with the genome of another ST167 E. coli clinical isolate containing blaNDM-5 and exhibiting susceptibility to cefiderocol and CZA-ATM, a 12–base pair insertion in ftsI, translating to a 4–amino acid duplication in PBP3, was identified. Moreover, a blaCMY-59 gene was harbored on an IncI-γ replicon type, and frameshift mutations were identified in the cirA iron transport gene.

Conclusions
This is the first clinical case of a US patient harboring an NDM-producing isolate exhibiting resistance to all available β-lactam agents. The isolate's unexpected resistance to cefiderocol and CZA-ATM was likely due to a combination of (1) a modified PBP3 (increased MICs to both regimens), (2) truncated iron-binding protein (increased cefiderocol MIC), and (3) a blaCMY gene (reduced CZA-ATM activity). E. coli ST167 clinical isolates harboring blaNDM-5 genes are a recognized international high-risk clone. When coupled with the additional mechanisms identified in our patient's isolate, which is not uncommon for this high-risk clone, pan-β-lactam resistance may occur.
Hypofractionated Stereotactic Re-irradiation and Anti-PDL1 Durvalumab Combination in Recurrent Glioblastoma: STERIMGLI Phase I Results
Authors: Pouessel Damien , Ken Soléakhéna , Gouaze-Andersson Valérie , Piram Lucie , Mervoyer Augustin , Larrieu-Ciron Delphine , Cabarrou Bastien , Lusque Amélie , Robert Marie , Frenel Jean-Sebastien , Uro-Coste Emmanuelle , Olivier Pascale , Mounier Muriel , Sabatini Umberto , Sanchez Eduardo Hugo , Zouitine Mehdi , Berjaoui Ahmad , Cohen-Jonathan Moyal Elizabeth 
Published: May 2023

Abstract

Background
Hypofractionated stereotactic radiotherapy (hFSRT) is a salvage option for recurrent glioblastoma (GB) which may synergize anti-PDL1 treatment. This phase I study evaluated the safety and the recommended phase II dose of anti-PDL1 durvalumab combined with hFSRT in patients with recurrent GB.

Methods
Patients were treated with 24 Gy, 8 Gy per fraction on days 1, 3, and 5 combined with the first 1500 mg Durvalumab dose on day 5, followed by infusions q4weeks until progression or for a maximum of 12 months. A standard 3 + 3 Durvalumab dose de-escalation design was used. Longitudinal lymphocytes count, cytokines analyses on plasma samples, and magnetic resonance imaging (MRI) were collected.

Results
Six patients were included. One dose limiting toxicity, an immune-related grade 3 vestibular neuritis related to Durvalumab, was reported. Median progression-free interval (PFI) and overall survival (OS) were 2.3 and 16.7 months, respectively. Multi-modal deep &#x2028;learning-based analysis including MRI, cytokines, and lymphocytes/neutrophil ratio isolated the patients presenting pseudoprogression, the longest PFI and those with the longest OS, but statistical significance cannot be established considering phase I data only.

Conclusion
Combination of hFSRT and Durvalumab in recurrent GB was well tolerated in this phase I study. These encouraging results led to an ongoing randomized phase II. (ClinicalTrials.gov Identifier: NCT02866747).
Fentanyl Absorption, Distribution, Metabolism, and Excretion: Narrative Review and Clinical Significance Related to Illicitly Manufactured Fentanyl
Authors: Bird H. Elizabeth , Huhn Andrew S. , Dunn Kelly E. 
Published: May 2023

Objectives
This narrative review summarizes literature on pharmaceutical fentanyl's absorption, distribution, metabolism, and excretion patterns to inform research on illicitly manufactured fentanyl (IMF).

Results
Fentanyl is highly lipophilic, lending itself to rapid absorption by highly perfused tissues (including the brain) before redistributing from these tissues to muscle and fat. Fentanyl is eliminated primarily by metabolism and urinary excretion of metabolites (norfentanyl and other minor metabolites). Fentanyl has a long terminal elimination, with a documented secondary peaking phenomenon that can manifest as “fentanyl rebound.” Clinical implications in overdose (respiratory depression, muscle rigidity, and “wooden chest syndrome”) and opioid use disorder treatment (subjective effects, withdrawal, and buprenorphine-precipitated withdrawal) are discussed. The authors highlight research gaps derived from differences in medicinal fentanyl studies and IMF use patterns, including that medicinal fentanyl studies are largely conducted with persons who were opioid-naive, anesthetized, or had severe chronic pain and that IMF use is characterized by supratherapeutic doses and frequent and sustained administration patterns, as well as adulteration with other substances and/or fentanyl analogs.

Conclusions
This review reexamines information yielded from decades of medicinal fentanyl research and applies elements of the pharmacokinetic profile to persons with IMF exposure. In persons who use drugs, peripheral accumulation of fentanyl may be leading to prolonged exposure. More focused research on the pharmacology of fentanyl in persons using IMF is warranted.
Reliability of the Modified Method for Sphericity Deviation Score Using Only the Involved Hip Radiographs in the Patients With Legg-Calve-Perthes Disease
Authors: Kang Michael Seungcheol , Kak Arnav , Prasadh Jai Ganesh , Kim Harry Kwang-Woo 
Published: May 2023

Background:
The sphericity deviation score (SDS) is a validated radiographic outcome measure that quantifies the severity of the femoral head deformity in the healed stage of Legg-Calve-Perthes disease (LCPD). The current method requires radiographs of both hips regardless of unilateral involvement to standardize radiographic magnification. As LCPD affects the unilateral hip in 85% to 90% of cases, the current method imposes unnecessary radiation exposure to most of the patients and having to exclude patients from research studies who only had unilateral hip radiographs. We thus modified the SDS method to use unilateral hip radiographs. The purpose of this study was to investigate the reliability of the modified SDS method using the radiographs containing only one hip.

Methods:
This retrospective study involved 40 patients with LCPD with unilateral involvement in the healed stage of LCPD. We modified the SDS measurement method by using the distance between the teardrop and the lateral acetabulum for magnification correction and providing a clear anatomic description of reference points on the femoral head. Three independent observers performed measurements using radiographs containing the affected hip only (modified method) and both hips (conventional method). The intraclass correlation (ICC) estimates were calculated. To verify clinical relevance, the correlation of the SDS with the Stulberg classification and hip range of motion (ROM) were also investigated.

Results:
Measurements using the modified SDS showed excellent inter-/intra-observer ICCs (0.903 to 0.978). The ICCs between the modified and conventional methods were also excellent: 0.940 to 0.966 within the same observer and 0.897 to 0.919 between different observers. The modified SDS showed moderate-to-strong correlations with the Stulberg classification (Spearman ρ=0.650) and hip ROM (Pearson r=−0.661).

Conclusion:
The modified SDS measurement method showed excellent inter-/intra-observer reliability and moderate-to-strong correlations with the Stulberg classification and hip ROM. This method will help reduce unnecessary radiation exposure in patients with unilateral LCPD and prevent the exclusion of patients with unilateral radiographs from future research studies.

Level of Evidence:
Level III—diagnostic study.
Menopause hormone therapy and urinary symptoms: a systematic review
Authors: Christmas Monica M. , Iyer Shilpa , Daisy Cassandra , Maristany Sumiko , Letko Juraj , Hickey Martha 
Published: May 2023

Abstract

Importance
Urogenital changes associated with menopause are now classified as genitourinary syndrome of menopause (GSM), which includes symptoms of urgency, frequency, dysuria, and recurrent urinary tract infections for which the recommended treatment is estrogen. However, the association between menopause and urinary symptoms and the efficacy of hormone therapy for these symptoms is uncertain.

Objective
Our objective was to define the relationship between menopause and urinary symptoms including dysuria, urgency, frequency, recurrent urinary tract infections (UTIs), and urge and stress incontinence by conducting a systematic review of the effects of hormone therapy (HT) for urinary symptoms in perimenopausal and postmenopausal women.

Evidence Review
Eligible studies included randomized control trials with perimenopausal and postmenopausal women with a primary or secondary outcome of the following urinary symptoms: dysuria, frequent UTI, urgency, frequency, and incontinence, included at least one treatment arm of estrogen therapy, and were in English. Animal trials, cancer studies and pharmacokinetic studies, secondary analyses, and conference abstracts were excluded. PubMed, Scopus, and the Cochrane Central Register of Controlled Trials were searched until April 2022. Two authors reviewed each article with discrepancies resolved through whole group consensus. Data extracted included the following: publication date, country, setting, subject number, follow-up, duration, age, race/ethnicity, study design, inclusion criteria, and main findings.

Findings
There is insufficient evidence to confirm that menopause is associated with urinary symptoms. The effect of HT on urinary symptoms depends on type. Systemic HT may cause urinary incontinence or worsen existing urinary symptoms. Vaginal estrogen improves dysuria, frequency, urge and stress incontinence, and recurrent UTI in menopausal women.

Conclusions and Relevance
Vaginal estrogen improves urinary symptoms and decreases the risk of recurrent UTI in postmenopausal women.
The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women
Authors: Chen Irene J. , Shoupe Donna , Karim Roksana , Stanczyk Frank Z. , Kono Naoko , Sriprasert Intira , Hodis Howard N. , Mack Wendy J. 
Published: May 2023

Abstract

Objective
While the deleterious associations of surgical menopause after bilateral oophorectomy with cardiovascular disease are documented, less is specifically known concerning subclinical atherosclerosis progression.

Methods
We used data from 590 healthy postmenopausal women randomized to hormone therapy or placebo in the Early versus Late Intervention Trial with Estradiol (ELITE), which was conducted from July 2005 to February 2013. Subclinical atherosclerosis progression was measured as annual rate of change in carotid artery intima-media thickness (CIMT) over a median 4.8 years. Mixed-effects linear models assessed the association of hysterectomy and bilateral oophorectomy compared with natural menopause with CIMT progression adjusted for age and treatment assignment. We also tested modifying associations by age at or years since oophorectomy or hysterectomy.

Results
Among 590 postmenopausal women, 79 (13.4%) underwent hysterectomy with bilateral oophorectomy and 35 (5.9%) underwent hysterectomy with ovarian conservation, a median of 14.3 years before trial randomization. Compared with natural menopause, women who underwent hysterectomy with and without bilateral oophorectomy had higher fasting plasma triglycerides while women who underwent bilateral oophorectomy had lower plasma testosterone. The CIMT progression rate in bilaterally oophorectomized women was 2.2 μm/y greater than natural menopause (P = 0.08); specifically, compared with natural menopause, the associations were significantly greater in postmenopausal women who were older than 50 years at the time of bilateral oophorectomy (P = 0.014) and in postmenopausal women who underwent bilateral oophorectomy more than 15 years before randomization (P = 0.015). Moreover, the CIMT progression rate in hysterectomized women with ovarian conservation was 4.6 μm/y greater than natural menopause (P = 0.015); in particular, compared with natural menopause, the association was significantly greater in postmenopausal women who underwent hysterectomy with ovarian conservation more than 15 years before randomization (P = 0.018).

Conclusions
Hysterectomy with bilateral oophorectomy and ovarian conservation were associated with greater subclinical atherosclerosis progression relative to natural menopause. The associations were stronger for later age and longer time since oophorectomy/hysterectomy. Further research should continue to examine long-term atherosclerosis outcomes related to oophorectomy/hysterectomy.
Rectus Muscle Plication in Mini-abdominoplasty with Umbilicus Preservation
Authors: El Israwi Daniel , Watfa William 
Published: May 2023

Summary:
Diastasis recti is a frequent problem that women, particularly, experience after pregnancy. It is an abdominal wall defect in which there is more than 2 cm separation between the abdominal rectus muscles. Aside from being repaired most commonly with a full abdominoplasty, in some cases, diastasis might present with minimal excessive adipocutaneous tissue, thus requiring a mini-abdominoplasty. Because umbilical transposition is not needed in that latter scenario, diastasis repair is only possible by ligating and cutting the existing umbilical stalk to be able to have a direct clear access to the supraumbilical linea alba. However, detaching the umbilical stalk will most certainly lead to the displacement of the umbilicus inferiorly. To overcome this problem, we performed a modified mini-abdominoplasty technique, which repairs the recti diastasis, keeps the umbilical stalk in place, and leaves behind a mini-abdominoplasty scar, thus providing a more cosmetically appealing result in addition to a radical solution to the defect. Moreover, this technique can be performed by any qualified plastic surgeon under basic operating settings.