bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal microbiota predictors for methicillin resistant Staphylococcus colonization in critically ill children
Authors: Zani Kathleen , Hobeika Joseph , Sun Yilun , Kohler Christina , Cherian Anju , Fields Trinity , Jia Qidong , Tang Li , Hysmith Nicholas D. , Margolis Elisa B. 
Published: January 2025

Background
Surveillance cultures to identify patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) is recommended at pediatric intensive care unit (PICU) admission but doesn’t capture other methicillin-resistant Staphylococcus and is resource intensive. We determined the prevalence and identified nasal microbiome predictors for methicillin-resistant Staphylococcus colonization at the time of PICU admission.

Study design
A prospective cohort study was performed in a 20-bed pediatric intensive care unit (PICU) between 2020–2021. Anterior nares nasal swabs processed for MRSA culture, nasal microbiome and mecA+ qPCR were obtained within first five days after PICU admission. Predictive values of methicillin-resistant Staphylococcus carriage on symptoms of infection and for nasal microbiome attributes were calculated.

Results
A total of 5 (8.0%) of 62 patients had a nares culture positive for MRSA and 22 (35.5%) of 63 patients had methicillin-resistant Staphylococcus (MRSA or methicillin-resistant coagulase-negative Staphylococci). In univariate analysis, carriage with MRSA or MRCoNS was associated with having a fever during PICU stay. Colonization with a distinct set of microbes (including Haemophilus, Streptococcus, Prevotella and Corynebacterium sp.) was predictive of having methicillin-resistant Staphylococcus colonization.

Conclusions
Carriage with methicillin-resistant Staphylococcus may lead to transmission in critically ill pediatric patients. Carriage of particular nasal microbes appears to facilitate colonization with methicillin-resistant Staphylococcus.
Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach
Authors: S. Devi Soorya Narayana , Sundararajan Vino 
Published: January 2025

Background
Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.

Methodology
Ten microarray datasets each for RA, and IBD, and nine datasets for dementia were obtained from Gene Expression Omnibus. We identified common differentially expressed genes (DEGs) and constructed a gene-gene interaction network. Subsequently, topology analysis for hub gene identification, cluster and functional enrichment, and regulatory network analysis were performed. The hub genes were then validated using independent microarray datasets from Gene Expression Omnibus.

Results
A total of 198 common DEGs were identified from which CD44, FN1, IGF1, COL1A2, and POSTN were identified as the hub genes in our study. These hub genes were mostly enriched in significant processes and pathways like tissue development, collagen binding, cell adhesion, regulation of ERK1/2 cascade, PI3K-AKT signaling, and cell surface receptor signaling. Key transcription factors TWIST2, CEBPA, EP300, HDAC1, HDAC2, NFKB1, RELA, TWIST1, and YY1 along with the miRNA hsa-miR-29 were found to regulate the expression of the hub genes significantly. Among these regulatory molecules, miR-29 emerged as a significant linker molecule, bridging the molecular mechanisms of RA, IBD, and dementia. Validation of our hub genes demonstrated a similar expression trend in the independent datasets used for our study.

Conclusion
Our study underscores the significant role of miR-29 in modulating the expression of hub genes and the associated transcription factors, which are crucial in the comorbidity status of RA, dementia, and IBD. This regulatory mechanism highlights miR-29 as a key player in the pathogenesis of these comorbid diseases.
Impact of hysterectomy on opioid use in patients with adenomyosis: A nationwide register study
Authors: Brunes Malin , Jonsdottir Gudny , Ek Marion , Kallner Helena Kopp , Hasselrot Klara 
Published: January 2025

Introduction
Dysmenorrhea and heavy menstrual bleeding are the most common symptoms in adenomyosis, in addition to infertility and chronic pelvic pain. Hysterectomy is a common treatment for adenomyosis symptoms with curative effect on heavy menstrual bleeding but with less studied effects on pain reduction.

Material and methods
This is a nationwide retrospective register-based cohort study including all hysterectomized patients with pathology-verified adenomyosis between 1 January 2012 and 31 December 2015 with a long-term follow-up three years pre- and three years postoperatively. Two national registers were linked in order to describe the primary outcome of proportion with use of opioids among hysterectomized patients with and without adenomyosis pre- and postoperatively. Logistic and multinomial regression models were used.

Results
A total of 2,228 (15%) patients had pathology-verified adenomyosis. Overall opioid use was 18.6% and 21.1% three years before and three years after surgery, respectively. Results showed a significantly increased risk of opioid use three years after hysterectomy in patients with preoperative use of opioids and antidepressants (adjusted Odds Ratio (aOR) 5.7, 95% Confidence Interval (CI) 4.5–7.2 and aOR 1.4, 95% CI 1.1–1.8). The risk of needing long-term opioids was higher among patients with smaller uteri (<300g, aOR 2.8, 95% CI 1.7–4.7) compared to women with uterine sizes ≥600g.

Conclusions
Hysterectomy does not reduce opioid use among adenomyosis patients in long-term follow-up, although the subjective reduction of pain was not investigated in this study. Women with preoperative use of opioids/antidepressants and uterine size <300g are at increased risk for chronic opioid use.
Seasonal dynamics of 25-OH vitamin D and biogenic amines in the blood of apparently healthy men living in the city of Arkhangelsk
Authors: Alikina V. A. , Elfimova A. E. , Molodovskaya I. N. , Tipisova E. V. , Zyabisheva V. N. 
Published: January 2025

BACKGROUND: The Arctic zone territories of the Russian Federation have the risk of developing 25-OH vitamin D deficiency, which is aggravated by low levels of insolation and nutrition low in vitamins and minerals. Along with low levels of insolation and reduced vitamin D concentrations during periods of minimal daylight hours, manifestations of seasonal affective disorder may occur, which is characterized by circadian dysregulation and monoaminergic functions of neurotransmitters (serotonin, dopamine, noradrenaline). The scientific challenge lies in estimating 25-OH vitamin D and biogenic amines sufficiency and detecting associative changes in 25-OH vitamin D and biogenic amines levels during various photoperiods of the year in the population of Arkhangelsk, as well as in further identification of typological variations in the intra-individual dynamics of the studied indicators depending on gender and daylight hours.AIM. The purpose is to assess the seasonal sufficiency of vitamin D and biogenic amines for apparently healthy men of working age living in the city of Arkhangelsk.METHODS. An analytical prospective uncontrolled study was conducted with the participation of 20 clinically healthy men from the city of Arkhangelsk (64°32’24.4’’N). Blood samples were collected every season (March, June, September, December) during the year with subsequent determination of the concentrations of vitamin D, serotonin, dopamine, adrenaline and noradrenaline in the blood. Statistical analysis of endocrine parameters was performed using the Wilcoxon rank test with the Bonferroni correction.RESULT: According to the revealed annual dynamics, the concentration of 25-OH vitamin D in the blood of men who live in the city of Arkhangelsk reached a minimum level during an increase in daylight hours (March), followed by an increase in vitamin concentration in summer (June) and a maximum concentration level during a decrease in daylight hours (September). The largest percentage of people (45%) with insufficient (below 30 ng /ml) vitamin D concentration in the blood is noted during the period of increasing daylight (March), while in summer and autumn this percentage decreases to 10, and in winter no insufficient concentrations of vitamin D are detected.CONCLUSION: In terms of vitamin D concentration in the blood of men, the period of increase in daylight hours (March) is the most critical season, whereas the period of decrease in daylight hours (September) is a more favourable one. Seasonal dynamics of serotonin concentrations were associated with changes in vitamin D levels during the year. Seasonal variations of dopamine, adrenaline and noradrenaline concentrations were similar to each other and different from the annual dynamics of vitamin D concentration in the blood.
Crystal structure of 2-(benzo[d]oxazol-2-yl)acetonitrile, C9H6N2O
Authors: Wang Juan , Feng Lei , Li Dongrun , Wang Litong , Meng Fanchao , Han Quanxiang , Jiang Jinke , Zheng Xiaoxin , Gao Xing 
Published: January 2025

Abstract
C9H6N2O, monoclinic, P21 (no. 4), a = 5.3241(3) Å, b = 7.1833(5) Å, c = 10.3407(7) Å, β = 99.811(6)°, V = 389.69(4) Å3, Z = 2, Rgt
(F) = 0.0763, Rref
(F
2) = 0.1836, T = 293(2) K.
Effects of Half-Time Re–Warm-Up With Core Strength Exercises on Subsequent Agility and Power Performance in Basketball Players
Authors: Yang Yun-Rong , Chen Chu , Pan Chi-Hsueh , Yen Shih-Yao , Cheng Ching-Feng 
Published: January 2025

Abstract
Yang, Y-R, Chen, C, Pan, C-H, Yen, S-Y, and Cheng, C-F. Effects of half-time re–warm-up with core strength exercises on subsequent agility and power performance in basketball players. J Strength Cond Res XX(X): 000–000, 2024—This study investigated the effects of half-time re–warm-up (RW) comprising core strength exercise (CSE) on basketball players' subsequent power and change of direction (COD) performance. Twelve male collegiate basketball players were recruited to perform 3 conditions––CSE RW on a stable platform (STA) or an unstable platform (USTA) and passive rest (control, CON)––in randomized, counter-balanced order after a modified Loughborough intermittent shuttle test (LIST). The COD and power performance tests were administered before the LIST and after the interventions. Heart rate (HR) was continuously measured during each trial. Results showed significantly lower changes in T-test time in STA compared with CON (p < 0.05). Changes in countermovement jump height in STA were significantly higher than those in CON (p < 0.05). During the isometric midthigh pull test, changes in the maximum rate of force development (RFD) (p < 0.05), RFD in the range of 0–90 milliseconds (p < 0.05), 0–150 milliseconds (p < 0.05), 0–200 milliseconds (p < 0.05), and 0–250 milliseconds (p < 0.05), in STA were significantly higher than those in CON. In addition, RFD in the range of 0–150 milliseconds (p < 0.05) and 0–250 milliseconds (p < 0.05) in USTA was significantly higher than that in CON. The mean HR during USTA was significantly higher than that in STA and CON (p < 0.05). These findings indicated that CSE RW during halftime might prevent power and COD performance decline in the second half of a game, with practical implications for coaches and players.
Estimation of Sensitivity Coefficients for Rockwell Indenters Using Finite Element Simulation for Uncertainty Evaluation
Authors: Tanaka Yukimi , Hattori Koichiro , Yoshioka Masahiro 
Published: January 2025

Abstract
Rockwell hardness testing is a widely used hardness test, and there are many scales depending on the indenter shape and test force for corresponding to various materials. The common Rockwell indenters are the diamond sphero-conical indenter and the tungsten carbide ball indenter. The influence of indenter shape error on Rockwell hardness has been acknowledged, as this shape impacts test results. To accurately estimate this uncertainty, it is essential to understand the sensitivity coefficient, which delineates the relationship between indenter shape and Rockwell hardness. Traditionally, this coefficient has been derived experimentally, but this approach faces challenges that are attributable to the nonuniformity of hardness test blocks and indenter shape measurement errors. This study introduces the estimation of sensitivity coefficients for Rockwell indenters using finite element analysis (FEA). The FEA method offers the advantage of being unaffected by the nonuniformity of test blocks and indenter shape measurement errors. We calculated the sensitivity coefficients by assessing the influence of variations in indenter angle and tip radius for diamond indenters, and indenter diameter for ball indenters, on hardness results through FEA. The sensitivity coefficients obtained via FEA for specific scales aligned with those from previous experimental studies, affirming the validity of FEA-derived coefficients for other scales. This study demonstrates that FEA is a useful tool for estimating the sensitivity coefficients of Rockwell indenters.
Study on the Mechanical Properties and Microstructure of Soil Stabilized with Alkali-Activated Slag–Steel Slag–Silica Fume
Authors: Shi Xianzeng , Xu Lei , Huang Kai , Cheng Fenfen , Zha Qingkun , Zhao Meng , Xie Yanmei , Fang Ziqiang , Pan Yangyang , Sun Ying 
Published: January 2025

Abstract
In order to solve the problem of low comprehensive utilization rate of industrial solid waste, this article focuses on the three problems of slag, which are steel slag, reuse of silica fume, and the strength enhancement and microscopic mechanism of slag-steel slag-silica fume composite material; analyzes the macro strength of the mixture under different curing ages from the two indexes of unconfined compressive strength and splitting tensile strength; and conducts microscopic tests such as X-ray diffraction, scanning electron microscopy, and Fourier transform infrared. The internal mechanism of hydration product formation and strength change of slag and steel wollastonite cementitious material under the excitation of sodium hydroxide and sodium silicate mixed solution as alkali activator was discussed. The strength results show that when the optimum mixture ratio of slag: steel slag: silica fume is 6:3:1, the modulus of lye is 1.2, the content of lye is 6 %, and the compressive strength of slag-steel slag-silica fume base polymer reaches 2.44 MPa under the standard curing condition of 28 day. The results show that the hydration products of geopolymer mainly consist of calcium-silicate-hydrate (C-S-H) gel and a small amount of ettringite (AFt) crystal. The addition of slag reduces the calcium/silicon ratio and increases the aluminum/silicon ratio, which makes the gel polymerization degree increase. C-S-H gel can be formed by the reaction of calcium hydroxide and silicon dioxide produced by steel slag hydration. Silica fume can provide highly reactive silicon for the system, and its seed effect and pozzolanic effect can accelerate the hydration process of the system.
Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice
Authors: Mayerl Steffen , Martin Andrea Alcaide , Bauer Reinhard , Heuer Heike 
Published: January 2025

Objective
Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) cause Allan–Herndon–Dudley syndrome (AHDS), a severe form of psychomotor retardation with muscle hypoplasia and spastic paraplegia as key symptoms. These abnormalities have been attributed to impaired TH transport across brain barriers and into neural cells, thereby affecting brain development and function. Likewise, Mct8/Oatp1c1 (organic anion-transporting polypeptide 1c1) double knockout (M/Odko) mice, a well-established murine AHDS model, display a strongly reduced TH passage into the brain as well as locomotor abnormalities. To which extent the peripheral nervous system is affected by combined MCT8/OATP1C1 deficiency has not been addressed.

Methods
Using the sciatic nerve as a model, we studied the spatiotemporal expression of TH transporters as well as the sciatic thyroidal state, sciatic nerve myelination and function in M/Odko mice by immunofluorescence, qPCR, Western blotting and electrophysiology.

Results
We detected MCT8 protein expression in sciatic nerve axons, whereas OATP1C1 expression was observed in a subset of endothelial cells early in postnatal development. The absence of MCT8 and OATP1C1 did not alter the thyroidal state of isolated nerves at P12. Moreover, electrophysiological studies did not disclose any significant alteration in sciatic nerve signal propagation parameters in adult M/Odko mice. Although Schwann cell numbers were similar, Western blot analysis showed a mild form of hypermyelination in adult M/Odko mice.

Conclusions
Altogether, our data point to a largely unaffected sciatic nerve structure and function in the absence of MCT8 and OATP1C1.
Contribution to the taxonomy of the Rotundabaloghia (Circobaloghia) mites (Acari: Uropodina: Rotundabaloghiidae)
Authors: Kontschán Jenő 
Published: January 2025

AbstractFour new Rotundabaloghia (Circobaloghia) species are described from South America and South-East Asia based on the collection of the Natural History Museum, London, UK. Rotundabaloghia (Circobaloghia) salebrosa sp. nov. was collected in Malaysia, Rotundabaloghia (Circobaloghia) bakerae sp. nov. was found in Sarawak (Malaysia), Rotundabaloghia (Circobaloghia) microseta sp. nov. is described from Guyana and Rotundabaloghia (Circobaloghia) peritremata sp. nov. was reported from Borneo (Indonesia).
Nuotolinio mokymosi virtualioje erdvėje iššūkiai COVID-19 pandemijos metu: studentų patirtys M. Buberio Aš-Tu ir Aš-Tai sąveikos perspektyvoje
Authors: Advilonienė Živilė 
Published: January 2025

Remiantis koleginio ir universitetinio lygmens studentų (N-61) patirtimis, nuotolinio kontaktinio mokymosi iššūkiai (techniniai, informaciniai, edukaciniai, psicho- emociniai, sveikatos, etiniai, socialiniai-teisiniai) straipsnyje gvildenti M. Buberio sąveikų Aš-Tu ir Aš-Tai perspektyvoje. Atskleista, kad nuotoliniame mokymesi orientuotasi į Aš-Tai sąveiką, žinių perteikimą, techninę paskaitų kokybę. Nenaudotos vaizdo kameros ribojo Aš-Tu dialogo sąveiką, tačiau sudarė prielaidas Aš-Tu sąveikai Aš-Tai dialogo sąlygų kontekste.
Ocean Space Surveillance and Real-Time Event Characterization Using Distributed Acoustic Sensing on Submarine Networks
Authors: Baird Alan F. , Morten Jan Petter , Oye Volker , Bjørnstad Steinar 
Published: January 2025

Abstract
Distributed acoustic sensing (DAS) can be deployed on existing submarine fiber-optic cables to add long-range sensor capability to the cable infrastructure. In this article, we present the following: (1) observations and analysis of impulsive source events from long-term DAS measurements on a North Sea submarine telecommunications cable. The observations include local earthquakes originating in the crust below the cable, underwater explosions originating in the water column, an onshore explosion from the nearby coast, and examples of sonic booms from supersonic aircraft and a suspected meteor from the atmosphere. The analysis reveals how the signals from earthquakes and underwater/aerial explosions can be distinguished in the data domain based on their frequency and apparent velocity characteristics. (2) A processing workflow enabling real-time marine surveillance including detection and location of explosions in the water column. The processing is verified by corroborating local earthquakes and underwater explosions with independent data sources. We show that different types of waves can be identified including seismic body waves, hydroacoustic waves, and atmospheric infrasound waves coupled through the water column. Tracking the travel-time moveout along the nonstraight cable route allows for positioning of the source, which we demonstrate by migration stacking of the recorded signal. Signal processing suitable for real-time classification and source location is applied to the recorded data and shows how ocean space surveillance at scale can be realized.
Conditioned Medium from Human Amniotic Membrane-Derived Mesenchymal Stem Cells Modulates Inflammatory and Myofibrotic Factors in Vivo
Authors: Asgharnezhad Ghazaleh , Mohammadi Sachli , Mohseni Mahdieh Mehrab , Mousvi-Niri Neda , Naseroleslami Maryam 
Published: January 2025

Background: Heart failure (HF) is a common condition associated with a high mortality rate, and while various treatment options exist, the therapeutic potential of human adipose-derived mesenchymal stem cells-conditioned medium (hAMSCs-CM) has garnered attention. To elucidate the mechanism behind hAMSCs-CM’s effects on HF, we conducted an animal study focusing on specific inflammatory and fibrotic factors.
Methods: Forty adult male Wistar rats were divided into 4 groups: control, HF, culture medium, and CM. All rats, except those in the control group, received an injection of isoproterenol to induce an animal model of HF. The CM group was administered the CM, while those in the culture medium group received standard culture media. Subsequently, serum levels of fibrotic factors, including TGF-β/galectin-3, MCP1, BNP, and ALD, were measured using ELISA. Statistical analysis was performed using one-way analysis of variance and the Tukey test.
Results: Serum levels of TGF-β/galectin-3, MCP1, BNP, and ALD were significantly elevated in the HF, CM, and culture medium groups compared with the control group (P<0.001). Additionally, these fibrotic factors were significantly reduced in the CM group compared with the HF group (P<0.001). Notably, CM therapy could not restore TGF-β/galectin-3, MCP1, BNP, or ALD levels to the normal range observed in the control group.
Conclusion: Our findings indicate that hAMSCs-CM modulates the expression of inflammatory and fibrotic cytokines, such as TGF-β/galectin-3, MCP1, BNP, and ALD, in isoproterenol-induced HF in male rats. These results contribute to a better understanding of the therapeutic mechanisms underlying hAMSCs-CM treatment for HF.
Desqualificação do outro e mobilizações intertextuais em interações polêmicas sobre o Projeto de Lei (PL) 580/ 2007
Authors: Oliveira Junior Ozeias Evangelista de , Mendes Jasmin Costa , Sousa Noemy Prazeres , Araújo Júnior João da Silva 
Published: January 2025

A expansão das redes sociais e as discussões que nela se desdobram advindas de temas da esfera social, intensificaram o fluxo de discursos que se entrecruzam nessas redes antagonicamente. Desse modo, esta pesquisa tem como objetivo analisar a partir das interações polêmicas sobre o PL 508/ 2007, o modo que os processos intertextuais são mobilizados em interações polêmicas com o objetivo de desqualificar o outro. Fundamentamo-nos nos estudos sobre a polêmica pública (AMOSSY, 2017), classificação do argumento ad hominem (FIORIN, 2015), interface entre Linguística Textual e a Teoria da Argumentação no Discurso (CAVALCANTE et al. 2020) e a intertextualidade no que diz respeito aos processos intertextuais estritos e amplos (CARVALHO, 2018). Para a análise dos dados, selecionamos uma publicação do perfil @ivetesangalo, em que a cantora se posiciona sobre o projeto de lei (PL) 580/2007, desta publicação, analisaremos interações polêmicas realizadas nos comentários da postagem. A análise permitiu constatar que a intertextualidade é mobilizada nas interações polêmicas com a intenção de desqualificar o outro e prosseguir vinculando-se a novas ideias e propagando-se nos ambientes virtuais, com a proposta argumentativa de defender o ponto de vista do locutor.