bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Evaluation of a UWB-Based Indoor Positioning System for Underground Mine Environments
Authors: Ziegler Moritz , Kianfar Amir Ehsan , Hartmann Tobias , Clausen Elisabeth 
Published: July 2023

AbstractAccurate positioning information is a central step in the process of increasing automation and digitalization in the mining industry. Underground mine environments are prime examples for GNSS-denied environments that pose several additional challenges for the employed indoor positioning system (IPS). This work presents an ultra-wideband (UWB)–based system specifically tailored for underground mine environments. Initially, the UWB technology is reviewed and basic concepts of IPS are explained. Both software and hardware are described in detail, including positioning algorithms, electrical circuitry, and the mining-compatible enclosure. Finally, the results from field tests in an underground mine are presented and positioning performance and the influence of dilution of precision (DOP) on positioning results are empirically evaluated. The results show that the localization errors are mostly below 1 m. Individual zones of high localization errors are suspected to be caused by noise interference. Significant DOP influence due to the mining drift geometry can be confirmed. The system shows promising localization results for different mining applications, while influences negatively impacting the accuracy are presented as items for future research.
Genome editing enables defense-yield balance in rice
Authors: Deng Yiwen , He Zuhua 
Published: July 2023

AbstractThis brief article highlights the key findings of the study conducted by Sha et al. (Nature, doi:10.1038/s41586-023-06205-2, 2023), focusing on the cloning of the RBL1 gene from rice, which is associated with lesion mimic mutant (LMM) traits. The RBL1 gene encodes a cytidine diphosphate diacylglycerol (CDP-DAG) synthase and plays a crucial role in regulating cell death and immunity by controlling phosphatidylinositol biosynthesis. The rbl1 mutant shows autoimmunity with multi-pathogen resistance but with severe yield penalty. Using genome editing techniques, the research team successfully generated an elite allele of RBL1 that not only restores rice yield but also provides broad-spectrum resistance against both bacterial and fungal pathogens. These findings demonstrate the potential of utilizing genome editing to enhance crop productivity and pathogen resistance.
The Sooner the Better: An Argument for Bias Toward the Earlier
Authors: SAAD BRADFORD 
Published: July 2023

ABSTRACTIn this article I argue that we should be prudentially and morally biased toward earlier events: other things equal, we should prefer for good events to occur earlier and disprefer for bad events to occur earlier. The argument contends that we should accord at least some credence—if only a small one—to a theoretical package featuring the growing block theory of time and that this package generates a presumptive bias toward earlier events. Rival theoretical packages are considered. Under reasonable allocations of credence to them, the presumptive bias escapes defeat. The argument has several corollaries: other things equal, we should be biased toward the past over the future, the further past over the nearer past, and the nearer future over the further future.
A locally time-invariant metric for climate model ensemble predictions of extreme risk
Authors: Virdee Mala , Kaiser Markus , Ek Carl H. , Shuckburgh Emily , Kazlauskaite Ieva 
Published: July 2023

Abstract
Adaptation-relevant predictions of climate change are often derived by combining climate model simulations in a multi-model ensemble. Model evaluation methods used in performance-based ensemble weighting schemes have limitations in the context of high-impact extreme events. We introduce a locally time-invariant method for evaluating climate model simulations with a focus on assessing the simulation of extremes. We explore the behavior of the proposed method in predicting extreme heat days in Nairobi and provide comparative results for eight additional cities.
Addressing the “Puzzle” of Gray-Area Sexual Violations
Authors: Cottone Nic 
Published: July 2023

AbstractThe gray area of sexual violations generally refers to ambiguous sexual experiences that are not readily distinguishable from rape or sex. Such experiences are describable as ambiguous or complex in a way that, to some, seems to defy existent categories of sexual experiences. This leads some feminists to approach the gray area as a puzzle that must be resolved either by understanding it as a new category, or by upholding existing rape categorization. Rather than dispelling the gray-area ambiguity by resolving conceptual puzzles, I assign the gray-area ambiguity a positive analytical role by attending to it in a historical and dialectical light. By tracing histories of feminist antirape discourse, I elaborate a way of understanding the “gray area” of sexual violations, articulating it as a historical condition affecting the interpretive possibilities of our sexual experiences. Such an approach underscores the potential of the gray area to inaugurate feminist critique in virtue of its status as a historically specific yet ambiguous horizon where our experiences can contradictorily seem not-like rape, but not-like sex.
An Invitation into the Mehfil: Muslim Women's Interregional Intellectual Networks
Authors: Paul Sreejata 
Published: July 2023

AbstractScholarship on prominent women's organizations of the early twentieth century highlights how American and European suffragists participated in and published reports about one another's activities. Less well-known are the exciting circuits of exchange that took place between women in Asia and Africa in spaces emerging out of colonial modernity. In this article, I explore how such circuits evoke cultural institutions embedded within shared histories of courtly patronage of the performing arts and rhetoric. To this end, I posit the mehfil as an alternative paradigm to capture how women's ideational networks operated within the Perso-Arabic sphere in the first half of the twentieth century. The mehfil, in addition to delineating neglected circuits of women's intellectual exchanges, also demonstrates how such exchanges, if attended to, pose certain tensions with known feminist histories. By broadening the definition of who we think of as early women activists or as pioneers of women's intellectual networks, it interrogates and intervenes within our understanding of first-wave feminisms. By foregrounding the interaction of claims for gender justice with anti-imperialist discourse, the mehfil provides an early model of women's collectivity that hinges not on demands for suffrage or other legislative reform, but on critique of colonial patriarchy.
The Nigerian Cabotage Act and the Ideals of the African Continental Free Trade Area: An Unwholesome Alliance?
Authors: Osinuga Damilola 
Published: July 2023

AbstractOne of the primary goals of the African Continental Free Trade Area (AfCFTA) is to establish a single market for goods and services in order to achieve economic integration in Africa. Experts opine that the AfCFTA can be a game changer for improving intra-African trade and may pave the way to economic diversification and inclusion. To maximize the potential of the AfCFTA, African nations must eliminate or minimize trade and non-trade barriers that can undermine the AfCFTA's true intention. Nigeria is the largest economy in Africa; therefore for the AfCFTA to flourish, Nigeria must implement targeted industrial, structural and policy changes to facilitate the achievement of the AfCFTA's objectives. This article addresses protectionist cabotage as a non-tariff trade hurdle to AfCFTA aims, as well as the need for Nigeria to abolish or liberalize its restrictive regime on domestic cabotage trade. It proposes that Nigeria should take the lead in campaigning for a regional cabotage regime and eliminate its protectionist policy.
Ameliorative effect ofStevia rebaudianaBertoni on sperm parameters,in vitrofertilization, and early embryo development in a streptozotocin-induced mouse model of diabetes
Authors: Abdi Mahdad , Alizadeh Fathemeh , Daneshi Erfan , Abouzaripour Morteza , Fathi Fardin , Rahimi Kaveh 
Published: July 2023

SummaryDiabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant effect on fertilization success and embryo development. The current study aimed to investigate the effect ofStevia rebaudianahydroalcoholic extract on serum testosterone levels, sperm parameters,in vitrofertilization (IVF) success, andin vitroembryonic developmental potential to reach the blastocyst stage in a streptozotocin (STZ)-induced mouse model of diabetes. In this research, 30 male mice were distributed randomly into control, diabetic (streptozotocin 150 mg/kg) and diabetic +Stevia(400 mg/kg) groups. The results revealed a decrease in body and testis weight and elevated blood fasting blood sugar (FBS) levels in the diabetic group, compared with the control. However,Steviatreatment significantly increased body and testis weight, while serum FBS levels were decreased compared with the diabetic group. In addition,Steviasignificantly increased blood testosterone levels compared with the diabetic group. Moreover, sperm parameters were improved considerably bySteviatreatment compared with the diabetic group. Furthermore,Steviaadministration significantly promoted IVF success rate andin vitrodevelopment of fertilized oocytes compared with the diabetic group. In summary, our data indicated thatSteviaenhanced sperm parameters, IVF success, andin vitroembryonic developmental competency in diabetic mice, probably because of its antioxidant effects. Therefore,Steviacould ameliorate sperm parameters that, in turn, increase fertilization outcomes in experimental-induced diabetes.
Evaluation of U.S. Army Soldiers wearing a back exosuit during a field training exercise
Authors: Slaughter P. R. , Rodzak K. M. , Fine S. J. , Ice C. C. , Wolf D. N. , Zelik K. E. 
Published: July 2023

Abstract
Back overuse injuries are a significant problem in the U.S. Army, responsible for nearly a quarter of musculoskeletal injuries. Back exosuits are wearable devices that relieve musculoskeletal strain, make lifting easier, and could potentially reduce Soldier overuse injuries. But published studies have not evaluated exosuits during realistic field operations to assess acceptability to Soldiers. We tested a back exosuit on field artillery Soldiers during a field training exercise. Afterward, Soldiers completed a survey to quantify their satisfaction, intent to use, and performance impact of the exosuit. Feedback was overwhelmingly positive: Approximately 90% of Soldiers reported that exosuits increased their ability to perform their duties, and 100% said that if the exosuit were further developed and made available to them, they would be likely to wear it. These numerical survey results indicated that exosuits can provide a practical and acceptable way to assist lifting and augment physical performance during realistic Army operations without interfering with other duties.
Impact of Diurnal Warm Layers on Atmospheric Convection
Authors: Shevchenko Radomyra , Hohenegger Cathy , Schmitt Mira 
Published: July 2023

AbstractThis manuscript presents a study of oceanic diurnal warm layers (DWLs) in kilometer‐scale global coupled simulations and their impact on atmospheric convection in the tropics. With the implementation of thin vertical levels in the ocean, DWLs are directly resolved, and sea surface temperature (SST) fluctuations of up to several Kelvin appear in regions with low wind and high solar radiation. The increase of SST during the day causes an abrupt afternoon increase of atmospheric moisture due to enhanced latent heat flux (LHF), followed by an increase in cloud cover (CC) and cloud liquid water (CLW). However, although the diurnal SST amplitude is even exaggerated in comparison to reanalysis, this effect only lasts for 5–6 hr and leads to an absolute difference of 1% for CC and 0.01 kg m−2 for CLW. This can be explained by the fact that the low wind over the SST anomalies dampens their potential effect on the LHF and hence clouds. All in all, the impact of DWLs on convective CC is found to be negligible in the tropical mean.
Impacts of Mesoscale Cloud Organization on Aerosol‐Induced Cloud Water Adjustment and Cloud Brightness
Authors: Zhou Xiaoli , Feingold Graham 
Published: July 2023

AbstractThe role of mesoscale cellular convection (MCC) in regulating aerosol‐induced cloud brightness remains unaddressed. Using 7 years of satellite‐based observations of cloud water adjustment to aerosol‐induced perturbations for closed MCCs across different sizes (8, 16, 32, and 64 km) over the North Atlantic Ocean, we show that MCC cell‐size plays a nontrivial role in regulating aerosol‐induced cloud brightness via cloud water adjustment. In cells that are primarily non‐precipitating, the adjustment in small‐scale MCCs can be 10 times more negative than in large‐scale MCCs, consistent with stronger evaporation via cloud top entrainment. Consequently, the response of cloud brightness is significantly stronger for large‐scale MCCs. We also find notable intra‐cell co‐variability between cloud liquid water path (LWP) and drop concentration (Nd) within MCCs that varies with cell size. Erroneously considering such co‐variability as a LWP response to Nd can lead to a significant positive bias, especially for small scale MCCs.
Direct Effects of Air Humidity on Dust Aerosol Production: Evidences for the Surprising Role of Electrostatic Forces
Authors: Ma Xiewen , Gao Qianqian , Jiang Xinghua , Chen Shaodong , Gan Yuqi , Zhang Tao , Lu Xiaohui , Wang Xiaofei 
Published: July 2023

AbstractDust aerosols are produced by wind erosion, and it is widely accepted that dust aerosols can be produced only if the wind speed exceeds a certain threshold velocity, which is largely controlled by soil moisture content. The relative humidity (RH) in the air could affect soil moisture content, thereby impacting dust production indirectly. However, it is not clear if the RH can directly change dust aerosol production. Here we simulated dust production and show that the RH does play a direct role in affecting the production of dust aerosol in a quite complicated way, which can be explained by a hypothesis that the RH affects both the electrostatic forces and wet‐bonding forces between soil particles in opposite directions. The current formula for dust aerosol production flux does not include the direct RH effect, and this study strongly suggests that it could lead to significant errors in estimating dust production.
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
Authors: Shyam Sunder Sunitha , Sharma Umesh C. , Pokharel Saraswati 
Published: July 2023

AbstractSince their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown significant utility in the treatment of multiple hematological malignancies and solid tumors, including chronic myelogenous leukemia, non-small cell lung cancers, gastrointestinal stromal tumors, and HER2-positive breast cancers. Given their widespread applications, an increasing frequency of TKI-induced adverse effects has been reported. Although TKIs are known to affect multiple organs in the body including the lungs, liver, gastrointestinal tract, kidneys, thyroid, blood, and skin, cardiac involvement accounts for some of the most serious complications. The most frequently reported cardiovascular side effects range from hypertension, atrial fibrillation, reduced cardiac function, and heart failure to sudden death. The potential mechanisms of these side effects are unclear, leading to critical knowledge gaps in the development of effective therapy and treatment guidelines. There are limited data to infer the best clinical approaches for the early detection and therapeutic modulation of TKI-induced side effects, and universal consensus regarding various management guidelines is yet to be reached. In this state-of-the-art review, we examine multiple pre-clinical and clinical studies and curate evidence on the pathophysiology, mechanisms, and clinical management of these adverse reactions. We expect that this review will provide researchers and allied healthcare providers with the most up-to-date information on the pathophysiology, natural history, risk stratification, and management of emerging TKI-induced side effects in cancer patients.
Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma
Authors: He Yong , Huang Guotao , Hong Shasha , Zuo Xiaohu , Zhao Zhihan , Hong Li 
Published: July 2023

AbstractFerroptosis is a special form of regulated cell death, which is reported to play an important role in a variety of traumatic diseases by promoting lipid peroxidation and devastating cell membrane structure. Pelvic floor dysfunction (PFD) is a kind of disease affecting the quality and health of many women’s lives, which is closely related to the injury of the pelvic floor muscle. Clinical findings have discovered that there is anomalous oxidative damage to the pelvic floor muscle in women with PFD caused by mechanical trauma, but the specific mechanism is still unclear. In this study, we explored the role of ferroptosis-associated oxidative mechanisms in mechanical stretching-induced pelvic floor muscle injury, and whether obesity predisposed pelvic floor muscle to ferroptosis from mechanical injury. Our results, in vitro, showed that mechanical stretch could induce oxidative damage to myoblasts and trigger ferroptosis. In addition, glutathione peroxidase 4 (GPX4) down-regulation and 15-lipoxygenase 1(15LOX-1) up-regulation exhibited the same variational characteristics as ferroptosis, which was much more pronounced in palmitic acid (PA)-treated myoblasts. Furthermore, ferroptosis induced by mechanical stretch could be rescued by ferroptosis inhibitor (ferrostatin-1). More importantly, in vivo, we found that the mitochondria of pelvic floor muscle shrank, which were consistent with the mitochondrial morphology of ferroptosis, and GPX4 and 15LOX-1 showed the same change observed in cells. In conclusion, our data suggest ferroptosis is involved in the injury of the pelvic floor muscle caused by mechanical stretching, and provide a novel insight for PFD therapy.
Membrane translocation process revealed by in situ structures of type II secretion system secretins
Authors: Yu Zhili , Wu Yaoming , Chen Muyuan , Huo Tong , Zheng Wei , Ludtke Steven J. , Shi Xiaodong , Wang Zhao 
Published: July 2023

AbstractThe GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse toxins that cause severe diseases such as diarrhea and cholera. GspD needs to translocate from the inner to the outer membrane to exert its function, and this process is an essential step for T2SS to assemble. Here, we investigate two types of secretins discovered so far in Escherichia coli, GspDα, and GspDβ. By electron cryotomography subtomogram averaging, we determine in situ structures of key intermediate states of GspDα and GspDβ in the translocation process, with resolution ranging from 9 Å to 19 Å. In our results, GspDα and GspDβ present entirely different membrane interaction patterns and ways of transitioning the peptidoglycan layer. From this, we hypothesize two distinct models for the membrane translocation of GspDα and GspDβ, providing a comprehensive perspective on the inner to outer membrane biogenesis of T2SS secretins.
Dynamic gel as artificial interphase layer for ultrahigh-rate and large-capacity lithium metal anode
Authors: Chen Chao , Zhang Jiaming , Hu Benrui , Liang Qianwen , Xiong Xunhui 
Published: July 2023

AbstractConstructing a stable artificial solid-electrolyte interphase has become one of the most effective strategies to overcome the poor reversibility of lithium metal anode, yet the protection role is still insufficient at elevated current densities over 10 mA cm−2 and large areal capacities over 10 mAh cm−2. Herein, we propose a dynamic gel with reversible imine groups, which is prepared via a cross linking reaction between flexible dibenzaldehyde-terminated telechelic poly(ethylene glycol) and rigid chitosan, to fabricate a protective layer for Li metal anode. The as-prepared artificial film shows combined merits of high Young’s modulus, strong ductility and high ionic conductivity. When the artificial film is fabricated on a lithium metal anode, the thin protective layer shows a dense and uniform surface owing to the interactions between the abundant polar groups and lithium metal. Besides, the polar groups in the artificial film can homogenize the distribution of Li+ at the electrode/electrolyte interface. As a result, cycle stability over 3200 h under an areal capacity of 10 mAh cm−2 and a current density of 10 mA cm−2 has been obtained for the protected lithium metal anodes. Moreover, cycling stability and rate capability has been also improved in the full cells.
Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes
Authors: Pitayu-Nugroho Laras , Aubry Mélanie , Laband Kimberley , Geoffroy Hélène , Ganeswaran Thadshagine , Primadhanty Audi , Canman Julie C. , Dumont Julien 
Published: July 2023

AbstractDuring cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for chromosome bi-orientation and accurate segregation. How these successive phases are controlled during oocyte meiosis remains elusive. Here we provide 4D live imaging during the first meiotic division in C. elegans oocytes with wild-type or disrupted kinetochore protein function. We show that, unlike in monocentric organisms, holocentric chromosome bi-orientation is not strictly required for accurate chromosome segregation. Instead, we propose a model in which initial kinetochore-localized BHC module (comprised of BUB-1Bub1, HCP-1/2CENP-F and CLS-2CLASP)-dependent pushing acts redundantly with Ndc80 complex-mediated pulling for accurate chromosome segregation in meiosis. In absence of both mechanisms, homologous chromosomes tend to co-segregate in anaphase, especially when initially mis-oriented. Our results highlight how different kinetochore components cooperate to promote accurate holocentric chromosome segregation in oocytes of C. elegans.