bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alkane production from fatty alcohols by the combined reactions catalyzed by an alcohol dehydrogenase and an aldehyde-deformylating oxygenase
Authors: Sui Yu-An , Maruyama Satoshi , Okada Natsumi , Ito Masakazu , Muramatsu Masayoshi , Obata Shusei , Ogawa Jun , Kishino Shigenobu 
Published: May 2023

ABSTRACT
PsADH, an alcohol dehydrogenase originating in Pantoea sp. was characterized and found to convert a broad variety of fatty alcohols into their corresponding aldehydes, the substrates of alkane biosynthesis. By coupling PsADH with NpAD, a cyanobacterial aldehyde-deformylating oxygenase, and by optimizing the conditions of the enzyme-catalyzed reactions, we achieved a 52% conversion of 1-tetradecanol to tridecane. We further applied this system to generate alkanes ranging from C5–17. These alkanes can be used as biofuels, suggesting that introducing a suitable alcohol dehydrogenase is an effective strategy to utilize fatty alcohols for alkane production.
CosTaL: an accurate and scalable graph-based clustering algorithm for high-dimensional single-cell data analysis
Authors: Li Yijia , Nguyen Jonathan , Anastasiu David C , Arriaga Edgar A 
Published: May 2023

Abstract
With the aim of analyzing large-sized multidimensional single-cell datasets, we are describing a method for Cosine-based Tanimoto similarity-refined graph for community detection using Leiden’s algorithm (CosTaL). As a graph-based clustering method, CosTaL transforms the cells with high-dimensional features into a weighted k-nearest-neighbor (kNN) graph. The cells are represented by the vertices of the graph, while an edge between two vertices in the graph represents the close relatedness between the two cells. Specifically, CosTaL builds an exact kNN graph using cosine similarity and uses the Tanimoto coefficient as the refining strategy to re-weight the edges in order to improve the effectiveness of clustering. We demonstrate that CosTaL generally achieves equivalent or higher effectiveness scores on seven benchmark cytometry datasets and six single-cell RNA-sequencing datasets using six different evaluation metrics, compared with other state-of-the-art graph-based clustering methods, including PhenoGraph, Scanpy and PARC. As indicated by the combined evaluation metrics, Costal has high efficiency with small datasets and acceptable scalability for large datasets, which is beneficial for large-scale analysis.
Characterizing M-estimators
Authors: Dimitriadis Timo , Fissler Tobias , Ziegel Johanna 
Published: May 2023

Summary
We characterize the full classes of M-estimators for semiparametric models of general functionals by formally connecting the theory of consistent loss functions from forecast evaluation with the theory of M-estimation. This novel characterization result allows us to leverage existing results on loss functions known from the literature on forecast evaluation in estimation theory. We exemplify advantageous implications for the fields of robust, efficient, equivariant and Pareto-optimal M-estimation.
BJS-02 INCIDENCE AND RISK FACTORS OF METACHRONOUS CONTRALATERAL INGUINAL HERNIA DEVELOPMENT UP TO 25 YEARS AFTER UNILATERAL INGUINAL HERNIA REPAIR: A SINGLE CENTRE COHORT STUDY
Authors: Glorieux R , Van Aerde M , Vissers S , Fieuws S , De Groof P , Miserez M 
Published: May 2023

Abstract

Background
Patients undergoing unilateral inguinal hernia repair (IHR) are at risk of metachronous contralateral inguinal hernia (MCIH) development, requiring reintervention in some cases. We evaluated incidence and risk factors of MCIH development up to 25 years after unilateral IHR to determine possible indications for simultaneous prophylactic surgery of the contralateral groin at the time of index surgery.

Methods
Patients between 18–70 years of age undergoing elective unilateral IHR in our centre from 1995 to 1999 were studied retrospectively using the electronic health records, and prospectively via phone calls. Study aims were MCIH incidence and risk factor determination. Kaplan-Meier curves were constructed and univariable and multivariable Cox regressions were performed.

Results
758 patients were included (91% male, mean age 51 years). Median FU-time was 21.75 years, mean FU-time was 18.3 years. The incidence of operated MCIH after 5 years was 5.6%, after 15 years 16.1%, and after 25 years 24.7%. The incidence of both operated and non-operated MCIH after 5 years was 5.9%, after 15 years 16.7%, and after 25 years 29.0%. MCIH risk was increased with higher age, and decreased in primary right-sided surgery and higher BMI at index surgery.

Conclusion
We believe these data do not provide enough clinical evidence to support prophylactic contralateral repair in all patients to avoid the development of a MCIH. We suggest a patient-specific approach taking into account MCIH risk factors, surgical approach and risk factors for chronic postoperative inguinal pain (CPIP).
BJS-06 LAPAROSCOPIC INTRACORPOREAL RECTUS APONEUROPLASTY (LIRA) TECHNIQUE VERSUS INTRAPERITONEAL ONLAY MESH CLOSING THE DEFECT (IPOM PLUS) FOR VENTRAL HERNIA REPAIR: COMPARATIVE RESULTS AT MEDIUM FOLLOW-UP
Authors: Menchero J Gómez , Balla A , Bohorquez A Gila , Fernandez Y Lara , Bolaños E Licardie , Luque J A Bellido , Morales-Conde S 
Published: May 2023

Abstract

Background
The primary aim of this prospective study is to compare the postoperative outcomes between LIRA technique and IPOM plus, in terms of recurrence and bulging rates at one-year follow-up; the secondary aim is to compare the postoperative complications, seroma and pain at 30 days and one-year after surgery.

Methods
Patients with midline ventral hernia of 4–10 cm in width were included. Seromaand recurrence was evaluated by Computed tomography scan 1 month and 1 year after surgery. Pain was evaluated using the visual analogue scale score.

Results
Forty-five and forty-seven patients underwent LIRA and IPOM plus, respectively. Preoperatively, smoke habitus rate was statistically significantly higher in LIRA group (20 patients, 44.4%) in comparison to IPOM group (5 patients, 10.6%) (p=0.0001). Statistically significant differences were not considering the intraoperative variables. Two bulgings (4.4%) occurred in the LIRA group, while in the IPOM group occurred 10 bulgings (21.3%) and three recurrences (6.4%) (p=0.017 and p=0.085, respectively). Postoperatively, seven (15.6%, Clavien-Dindo I) and four complications (8.5%, two Clavien-Dindo I and two Clavien-Dindo III-b) occurred in the LIRA and in the IPOM group, respectively (p=0.298). One month after surgery, clinical seroma, occurred in five (11.1%) and eight patients (17%) in the LIRA and in the IPOM group, respectively (p=0.416). During follow-up, pain reduction occurred, without statistically significant differences.

Conclusions
LIRA showed lower bulging and recurrence rates in comparison to IPOM plus at one-year follow-up. Further prospective studies, with a large sample of patients and longer follow-up are required to draw definitive conclusions.
BJS-07 COMPARISON OF ENDOSCOPIC ENHANCED-VIEW TOTALLY EXTRAPERITONEAL PROSTHETIC (ETEP) VERSUS OPEN RIVES-STOPPA REPAIR AS TREATMENT OF MIDLINE ABDOMINAL WALL HERNIAS WITH RECTUS DIASTASIS: SINGLE-CENTRE SURGICAL COHORT
Authors: Kinet S , Maes H , Van Cleven S , Brusselaers N , Kuppens E F P 
Published: May 2023

Abstract

Aim
The Rives-Stoppa (RS) procedure is a gold standard in the treatment of midline abdominal wall hernias. Comparability of pain control and outcomes to the less invasive enhanced-view totally extraperitoneal prosthetic (eTEP) repair remain unclear.

Material & Methods
Single centre surgical cohort including 30 RS repairs (January 2019 – November 2021), and 30 consecutive eTEP procedures (September 2021 – August 2022) for midline abdominal wall hernia(s) with rectus abdominis diastasis. Postoperative pain and outcomes were compared.

Results
Presence and median duration of patient-controlled analgesia (PCA) were respectively 90% and 3 nights with RS, versus 30% and 0 nights with eTEP. Median switch to only oral analgesics occurred at postoperative day (POD) 3 after RS and at POD 2 after eTEP. Postoperative analgesics and opioid prescription at discharge were comparable between groups. Median length of hospital stay was 6 nights after RS versus 3 nights after eTEP. Median duration of surgery was 110.5 and 164.5 minutes for RS and eTEP respectively. After RS, 30 patients had a postoperative drain compared to 3 patients after eTEP. Conversion was needed in 3 eTEP procedures. Postoperative complications were comparable. No early recurrences were observed. Minimal residual diastasis was observed at postoperative consultation in 11 patients after eTEP.

Conclusions
eTEP is a feasible minimally invasive alternative to RS for the treatment of midline abdominal wall hernias with rectus abdominis diastasis and is associated with a shorter length of hospital stay, less postoperative pain and a comparable risk of short-term complications.
Registration number: NCT05446675 (ClinicalTrials.gov).
OC-004 CAN AI HELP IN EARLY PREDICTION OF SURGICAL SITE INFECTIONS?
Authors: Bawa A , Kansal R , Kalra V , Rengan V , Sundaram P , Ramana B 
Published: May 2023

Abstract

Background
The use of Artificial Intelligence (AI) in healthcare has the potential to transform medical diagnosis, including the detection of surgical site infections (SSI). Real-time monitoring of surgical sites and early detection of infection through AI can lead to prompt treatment, improving patient outcomes and reducing healthcare costs and spread of infections in healthcare facilities.

Aim
This study aimed to determine the use of AI in the early detection of surgical site infections and its impact on patient recovery.

Materials and methods
The study analysed patients admitted to the hospital over the past year with SSIs. A novel AI device was used to image the wound and detect presence of infection through fluorescence lights that identify bacteria through bioluminescence. Targeted tissue cultures were taken, antibiotics were administered. Some wounds required targeted debridement. Daily dressings were done followed by secondary suturing.

Results
A total of 34 patients were included in the study, with a mean age of 52.4 years and 14 female and 20 male patients. 25 patients reported pus from the wound, 9 had serous discharge, and 19 had slough present. In 85.2% of patients, the AI device's gram stain for bacteria in the wound was similar to the tissue culture report. The mean time for wound healing was 39.52 days.

Conclusion
Our study suggests that AI devices can accurately identify the gram stain of bacteria in a wound, leading to prompt antibiotic treatment for patients with SSIs. This could have significant benefits in improving patient outcomes and healthcare costs.
OC-009 DIASTASIS RECTI. MDT POST-PREGNANCY PROGRAM
Authors: Santilli O , Santilli H , Nardelli N , Poso F , Paolucci P , Scaravonati R 
Published: May 2023

Abstract

Aim
To analyze the results collected by the multidisciplinary program.

Material & Methods
The diastasis post-pregnancy program used a systematic evaluation that included an abdominal wall surgeon, plastic surgeon, physiotherapist, nutritionist, and radiologist. The physiotherapist used tests to analyze the strength, stability, and functionality of the abdominal wall, also evaluating synergy with the diaphragm and pelvic floor. The same tests were used to check up on the treatment, plus the ultrasound evaluation.
We propose a classification, adapting the specific treatment depending on the degree of the patient's condition. Grade I (Increase in Waist): performed physiotherapy; Grade II (Bulge): started physiotherapy plan, with associated surgical treatment due to lack of response; Grade III (Herniation): underwent surgery as the first treatment in addition to physiotherapy protocol.
Endoscopic Rives-Stoppa has been used to repair midline hernias and diastasis.

Results
From January 2017 and June 2022, 1344 patients completed the program. The average age was 42. The most frequent clinical entity for consultation was: cosmesis discomfort (84%). According to the Clinical classification: Grade I: 941 patients (70%)only performed physiotherapy treatment. Grade II: 307 patients (22%), surgical treatments were necessary on 113 patients (36%). Grade III: 96 patients (7%) and 34% require a dermolipectomy. The bulging with functional test deficits is related in all patients. Physiotherapy tests and ultrasound check-ups post-treatment showed improvement in 77% of patients.

Conclusions
The diastasis recti must focus from three points of view: anatomical, functional, and cosmesis. The multidisciplinary approach concept showed good initial results.
OC-011 SARCOPENIA IN COMPLEX ABDOMINAL WALL SURGERY: IMPACT ON THE POSTOPERATIVE COMPLICATIONS
Authors: Santana Valenciano A , Juez Saez L D , Robin A , Porrero B , Muñoz J , Molina J M , Lopez Monclus J , Garcia Ureña M A , Fernandez Cebrian J M , Blazquez Hernando L 
Published: May 2023

Abstract

Aim
Sarcopenia is defined as the skeletal muscle mass loss and is considered as a prognostic factor in oncological surgical patients, liver transplant and trauma surgery. It can be reversed with exercise and diet. Nonetheless there is a lack of evidence of its impact on complex abdominal wall surgery. The aim is to evaluate the impact of sarcopenia in postoperative complications after complex incisional hernia repair.

Material and Methods
Retrospective study of patients undergoing surgery for complex incisional hernias &gt;10cm (W3 of European Hernia Society classification) between 2014–2021. Sarcopenia was stablished as the skeletal muscle index (SMI), measured at L3 transversal section of a preoperative CT-scan. Previously defined literature-based SMI cutoff values were used: men &lt;52,4cm2/m2, women &lt;38,5cm2/m2.

Results
We included 105 patients, of which 29 (27,6%) were sarcopenic. The mean follow-up was 24,11 (19,28) months. The mean age and body mass index was 65,34 (10,98) and 31,85 (5,55), respectively. Sarcopenia was significantly associated with a higher risk of death [OR 11,21 (IC95% 2,76–45,52); p=0,001]. We observed a difference in need of intensive care unit (ICU) stay [OR 2,24 (IC95% 0,88–5,69); p=0,089] and cardiac complications [OR 2,96 (IC95% 0,79–11,11); p=0,108], not reaching statistical significance. Differences in surgical site occurrence or infection were not observed. After analysing by possible cofounding factors (age, comorbidities, ICU stay), sarcopenia remains associated with a higher risk of death [OR 9,08 (IC95% 2,08–39,59); p=0,003].

Conclusions
Given the results of our study sarcopenia might increase the risk of death, independent of age, comorbidities and ICU stay.
OC-015 IMPACT OF DISCLOSURE OF RADIOGRAPHIC TEST RESULTS ON QUALITY OF LIFE AMONG PATIENTS WITH OCCULT HERNIAS: A RANDOMIZED CONTROLLED TRIAL
Authors: Olavarria O , Lyons N , Bernardi K , Dhanani N , Neela N , Arakelians A , Holihan J , Liang M 
Published: May 2023

Abstract

Aim
Ventral and groin hernias are commonly diagnosed using radiographic imaging. We aimed to determine if informing patients of the presence of a clinically apparent or occult hernia on imaging would change their abdominal wall quality of life (AW-QOL).

Materials and Methods
Consecutive patients with a hernia on elective CT abdomen/pelvis were enrolled. Patients underwent standardized abdominal examination by surgeons, and completed the modified Activities Assessment Scale, a validated, hernia-specific AW-QOL survey. On this scale, 1 is poor AW-QOL, 100 is perfect, and the minimally clinically important difference is 7. Patients were randomized to complete the one-year follow-up survey before or after being informed of the presence of a hernia on their imaging results. Primary outcome was change in AW-QOL compared to baseline.

Results
Of 169 patients randomized, 126 (75%) completed follow up at one-year. Among patients with occult hernias, those who completed the follow-up survey after being informed of having a hernia had a lower follow-up AW-QOL (mean difference -7.6, 95% CI = -20.8 to 5.7, p=0.261) compared to those who completed the survey before being informed. Conversely, for patients with clinical hernias, those who completed the survey after being informed had higher adjusted follow-up AW-QOL (mean difference 10.3, 95% CI = -3.0 to 23.6, p = 0.126) than those that completed it after.

Conclusions
Conveying findings of hernias found on CT imaging can influence patients’ AW-QOL. Future research should focus on identifying and addressing patients’ concerns after disclosure of CT results.
OC-016 ASSESSMENT OF PATIENT AND SURGEON PERCEPTIONS ON PROPHYLACTIC MESH: A STANDARD GAMBLE
Authors: Neela N , Lyons N , Nguyen K , Olavarria O , Dhanani N , Bernardi K , Cohen B , Harris H , Hughes T , Kao L , Liang M 
Published: May 2023

Abstract

Aim
Ventral incisional hernia (VIH) is a common complication after abdominal surgery. The use of prophylactic mesh can reduce its incidence however, this also has risks. Our aim was to determine the percent risk of wound complications that surgeons and patients would be willing to accept in the use of prophylactic mesh for a reduced risk of VIH.

Materials and Methods
We performed a cross-sectional standard gamble study with three clinical scenarios: abdominal surgeries at low, medium, and high-risk of VIH and wound complications. Participants were given an option of suture or mesh closure and provided the estimated mean risk of VIH with either technique. In a step-wise fashion, participants were provided increasing risks of wound complications until they chose suture over mesh. Estimated mean risk of VIH and wound complications were compiled through systematic review of randomized controlled trials and ACS-NSQIP risk calculator.

Results
Overall, 35 surgeons and 9 patients were surveyed. For the low, medium, and high-risk scenarios surgeons’ and patients’ maximal accepted risks was 3% and 11%, 11% and 18%, and 23% and 28%, respectively. For all three scenarios, surgeons reported risk-tolerance of prophylactic mesh far below that of the ACS-NSQIP risk calculator while patients were willing to accept more risk than the surgeons.

Conclusions
Surgeons and patients have different risk tolerances for various types of complications. Substantial education is needed for both surgeons and patients prior to widespread adoption of prophylactic mesh.
OC-017 Robotic abdominal wall program surgery: Initial experience of our first 101 cases
Authors: Villalobos R , Maestre Y , González-Barranquero A , Mias C , Escartin A , Olsina J 
Published: May 2023

Abstract

Aim
Minimally invasive surgery in abdominal wall had spread exponentially in the last decade, specially with the robotic surgery appearance. In our hospital, the Abdominal Wall Unit started the robotic program in 2019. The experience of our team in laparoscopic surgery allowed us to introduce the robotic surgery in complex abdominal wall pathologies. The aim of this study is to describe our experience of the progressive evolution that we had in our first 101 cases

Material and Methods
Patients with ventral/incisional hernias with medium and high complexity with no loss of domain, parastomal and inguinal hernias. The surgeries were performed by X or Xi DaVinci robotic platform.

Result
101 patients (115 surgeries) were considered in our study. All of them underwent robotic abdominal wall surgery. Women were 46 (45,5%) and men 55 (54,5%). The mean IBM was 34 (±3,7). The main hernia was in the midline: 53 (52,5%), the more frequent techniques were eTEP 32 (31,7%), RoboTAR (intrabdominal transversus abdominis muscle release) 19 (18,8%), bilateral inguinal TAPP 16 (15,9%) and Pauli 15 (14,9%). Also, we performed 11(10,9%) patients with our protocol with botulinum toxin called Robotox decreasing the TAR procedure. The RoboTAR had the most operating time mean: 315 min (260–350) while eTEP had 225 min (180–269). 4 (3,9%) patients had a recurrence with a follow-up of 26 months (3–37).

Conclusion
The implementation of a robotic program in an abdominal wall surgery unit is possible but it is necessary to standarize a training program to improve progressively the skills.
OC-018 Elective recurrent inguinal hernia repair. Value of an Abdominal Wall Surgery Unit
Authors: Martinez Lopez M , Rodrigues Gonçalves V , Verdaguer Tremolosa M , Martinez Lopez P , Bergamini S , Lopez Cano M 
Published: May 2023

Abstract

Purpose
The aim of this study is to analyze the influence of an abdominal wall surgery unit in postoperative complications (within postoperative 90 days), hernia recurrence and chronic postoperative inguinal pain after elective recurrent inguinal hernia repair.

Methods
This retrospective cohort study included patients who underwent elective recurrent inguinal hernia repair between January 2010 and October 2021. The short- and long-term outcomes between the groups of patients operated on by the Abdominal Wall Surgery Unit and groups operated on by surgeons outside of the specialized abdominal wall group were compared. A logistic regression model was performed for hernia recurrence.

Results
A total of 250 patients underwent elective surgery for recurrent inguinal hernia during the study period. Patients in the abdominal wall surgery group were younger (P= &lt;0.001) and had less comorbidities (P= &lt;0.001). Complications were similar in both groups. Patients in the abdominal wall surgery group presented fewer recurrences (15% vs 3%; P= 0.001). In the multivariate analysis, surgery performed by the abdominal wall surgery unit was related to fewer recurrences (HR= 0.164; 95% CI= 0.44–0.613; P=0.007).

Conclusions
Recurrent inguinal hernia repair is associated with better results in terms of recurrence when it is performed by a specialized abdominal wall unit.
OC-020 QUANTITATIVE EVALUATION OF THE ABDOMINAL WALL MECHANICAL BEHAVIOR BY A NEW CONNECTED ABDOMINAL BINDER: A PRELIMINARY STUDY
Authors: Bege T , Joppin V , Gueroult P , Masson C 
Published: May 2023

Abstract

Aim
Abdominal wall hernias result from a mechanical conflict between forces acting on the wall (mainly intra-abdominal pressure (IAP)) and its ability to deform. An abdominal binder instrumented with sensors has been developed to non-invasively quantify the deformation during straining.

Methods
A prospective study was conducted on eight healthy subjects. External deformations were evaluated by a patented connected binder instrumented with resistive sensors covering anterolateral area. IAP was evaluated by intragastric ingested sensor (SmartPill™, Medtronic), and wall muscles deformation by dynamic MRI (semi-automated segmentation method applied to rectus abdominis (RA) and lateral muscle (LM)). The relationship between these signals has been investigated during Valsalva maneuver.

Results
The binder provided time-related mapping of the abdominal deformation. Two different patterns were individualized corresponding to RA and LM areas. Deformation rate (mean 1.21mV/s for RA and 1.66mV/s for LM) and maximum signal (mean 3.03mV for RA and 4.24mV for LM) were recorded. These binder patterns were both correlated with the deep deformation in abdominal muscles observed in MRI (Pearson R=0.89 for RA, and R=0.94 for LM; p&lt;0.005). The binder patterns were also significantly correlated with the IAP variation (Pearson R=0.98 for RA and R=0.99 for LM; p&lt;0.005).

Conclusion
This non-invasive connected and instrumented abdominal binder simply and quickly reflects the abdominal wall muscles deformation and IAP variation during Valsalva maneuver. A larger study is needed to investigate inter-individual variability, and to evaluate the links between quantitative mechanical behavior and surgical outcomes during hernia surgery.