bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the Kiwi OmniCup system with maternal and neonatal morbidity: A retrospective cohort study
Authors: Wang Yue , Niu Yanxia , Xu Ziyi , Yan Xiaomeng , Li Jinhang , Xu Hongbin 
Published: August 2023

AbstractObjectiveTo discuss the effect of the Kiwi OmniCup system on reducing adverse maternal and neonatal outcomes and provide a reference for assisted vaginal delivery methods.MethodsWomen who gave birth to singleton term neonates in a cephalic presentation and underwent assisted vaginal delivery from 2017 to 2021 were eligible for inclusion in the study; they were divided into a Kiwi OmniCup system group and a forceps group. Binary logistic regression analysis was used to observe and compare maternal and neonatal outcomes. The primary outcomes were severe maternal and neonatal morbidity. Severe maternal morbidity was defined as the occurrence of at least one of the following outcomes: third‐ or fourth‐degree perineal lacerations, refractory postpartum hemorrhage, thrombotic events, amniotic fluid embolism, admission to the intensive care unit, and maternal death. Severe neonatal morbidity was defined as the occurrence of at least one of the following outcomes: neonatal asphyxia requiring resuscitation or intubation, neonatal head and face injuries, neonatal fracture, and admission to the neonatal intensive care unit for longer than 24 h.ResultsThe rate of severe neonatal morbidity in the forceps group was significantly higher than that in the Kiwi OmniCup system group, the differences between the two groups were significant (27.2% vs. 42.3%, P < 0.001), and there was no significant difference in the rate of severe maternal morbidity between the two groups (30% vs. 30%, P > 0.05). Binary logistic regression analysis showed that Kiwi OmniCup system‐assisted delivery reduced severe neonatal morbidity (adjusted odds ratio 0.49; 95% confidence interval 0.33–0.73) and did not increase severe maternal morbidity compared with forceps‐assisted delivery.ConclusionThe Kiwi OmniCup system, which can reduce the incidence of severe neonatal morbidity without increasing the incidence of serious adverse maternal outcomes, is worthy of clinical promotion.
Terrestrial water storage anomaly estimating using machine learning techniques and satellite‐based data (a case study of Lake Urmia Basin)
Authors: Soltani Keyvan , Azari Arash 
Published: August 2023

AbstractIn this study, the Terrestrial Water Storage Anomaly (TWSA) in the Lake Urmia Basin (LUB) was obtained by using the GRACE satellites. The whole study area was covered by 10 GRACE/GFO pixels, and the TWSA value was calculated for these 10 pixels. Examining the changing trend showed that the value of TWSA in the LUB has a decreasing trend and fluctuates from approximately −200 to +200 compared to the average value. The TWSA was modelled using the group method of data handling (GMDH) by considering six different parameters obtained from the European Centre for Medium‐Range Weather Forecasts (ECMWF) Reanalysis V5 (ERA5) and the Global Land Data Assimilation System version 2.0 (GLDAS V2.0). Finally, the best models with two to six input variables were selected. Among the models with different inputs, the GMDH Model 2, with three inputs, had the best performance compared to the other models. After choosing the best inputs in calculating the TWSA value by the GMDH, the TWSA value was also modelled by using the Adaptive Neuro‐Fuzzy Inference System (ANFIS), the Extreme Learning Machine (ELM) and the Artificial Neural Network (ANN). The results showed that GMDH not only outperformed other models but also provided some simple equations to apply in practical tasks.
Interactions among the composition changes in fungal communities and the main mycotoxins in simulated stored wheat grains
Authors: Wang Ruihu , Li Mengmeng , Jin Rui , Liu Yuanxiao , Guan Erqi , Mohamed Sherif Ramzy , Bian Ke 
Published: August 2023

AbstractBACKGROUNDThere are significant food safety risks associated with wheat spoilage due to fungal growth and mycotoxin contamination. Nevertheless, a few studies have examined how stored wheat grain microbial communities and mycotoxins vary in different storage conditions. In this study, changes in deoxynivalenol (DON) and deoxynivalenol‐3‐glucoside (D3G) content were measured with ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS), and an amplicon sequence analysis of fungi was performed on stored wheat grains from different storage conditions using high‐throughput sequencing. The detailed interactions among the composition changes in the fungal community and the DON content of simulated stored wheat grains were also analyzed.RESULTSAlternaria, Fusarium, Mrakia, and Aspergillus were the core fungal taxa, and the fungal communities of samples stored under different conditions were observed to be different. Aspergillus relative abundances increased, whereas Fusarium decreased. This led to an increase in the content of DON. The content of DON increased about 67% with 12% moisture and at 25 °C after 2 months of storage, which was influenced by the stress response of Fusarium. Correlations in fungal and mycotoxins changes were observed. There may be potential value in these findings for developing control strategies to prevent mildew infestations and mycotoxins contamination during grain storage.CONCLUSIONIn storage, the more the fungal community composition and the relative abundance of Fusarium change, the more mycotoxins will be produced. We should therefore reduce competition between fungal communities through pre‐storage treatment and through measures during storage. © 2023 Society of Chemical Industry.
A dilute‐and‐inject low‐pressure gas chromatography‐tandem mass spectrometry method for phthalate determination in extra virgin olive oil
Authors: Ferracane Antonio , Zoccali Mariosimone , Arena Alessia , Mondello Monica , Tranchida Peter Q. , Mondello Luigi 
Published: August 2023

The goal of this study was to develop a method for the determination of nine phthalic acid esters in extra virgin olive oils using low‐pressure gas chromatography‐triple‐quadrupole mass spectrometry. Sample preparation was simple, environmental friendly, and rapid inasmuch that it involved only dilution (< 1 mL of hexane). The low‐pressure gas chromatography analyses were performed by using a 5 m wide‐bore column. The limit of quantification for the phthalates ranged from 0.06 to 1.14 mg kg−1. Both intra‐ and interday precisions were measured, with coefficient of variation values ranging from 0.2% to 11.7%. The trueness of the method was measured by evaluating accuracy at the initial stage of the work and after 2 months, with values ranging between −8.7% and 12.1%. Moreover, blind accuracy was comprised between −11.6% and 14.2%. The method involves the use of simplified instrumentation and reduced analysis times (nearly two times faster) compared to a previously published comprehensive two‐dimensional gas chromatography‐triple‐quadrupole mass spectrometry method, leading to a reduction of energy and helium consumption. The approaches were compared in analytical terms and for the environmental impact. In total, 23 olive oil samples were analyzed, with at least one phthalate detected in all but one sample.
Effect of thermal and ultraviolet exposure on volatile organic compounds emitted from basalt‐hemp reinforced polypropylene
Authors: Rhodes Kyleigh , Jobson Thomas , Pelaez‐Samaniego Manuel Raul , Yadama Vikram 
Published: August 2023

AbstractIn recent years, the “new car smell” has been linked to materials off‐gassing toxic volatile organic compounds (VOCs) within the chamber of vehicles. Previous studies collected air samples directly from the vehicle chamber and analyzed them using gas chromatography–mass spectrometry (GC–MS). However, there is a lack of data regarding which materials are responsible for each compound and the resulting concentrations. This preliminary research was focused on analysis of VOC emissions emitted from basalt fiber and hemp hurd‐reinforced polypropylene (PP) panels, glass fiber reinforced PP panels, and PP panels intended for interior automotive applications such as dashboards and door panels. The panels were subjected to various temperatures and UV radiation that may be experienced within a vehicle. Results showed increasing concentrations as temperature increased, and a reduction in off‐gassing in the presence of UV radiation. The major compounds detected were acetaldehyde (<41 μg/m3), acetone (<29 μg/m3), and various alkanes (<6786 μg/m3). Overall, the concentrations detected from all panels were below the suggested standards and limitations.
Therapeutic efficacy and safety of a free‐standing motorized ejaculation aid for patients with intravaginal ejaculatory dysfunction
Authors: Fukuhara Shinichiro , Shirai Masato , Ueda Norichika , Takezawa Kentaro , Ishikawa Keisuke , Hiramatsu Ippei , Uesaka Yuka , Nozaki Taiji , Iwasa Atsushi , Kobayashi Kazuhiro , Nonomura Norio , Tsujimura Akira 
Published: August 2023

AbstractPurposeThere are no approved drugs or devices for the treatment of intravaginal ejaculation disorders, and treatment is often difficult. This study aimed to evaluate the efficacy and safety of the A10 Cyclone SA + PLUS® ejaculation aid (Rends Co., Ltd., Chiba, Japan), which allows the user to adjust the intensity of stimulation, for intravaginal ejaculation disorders.MethodsEach participant was instructed to perform practice masturbation with the A10 Cyclone SA + PLUS to simulate vaginal ejaculation. After 8 weeks of training, the participants were asked about their intravaginal ejaculation status. Sexual function was also evaluated before and after the training using several specific questionnaires, including the numerical rating scale for ejaculatory satisfaction.ResultsAmong the 10 participants (41.5 ± 3.21 years) who completed the training and questionnaire evaluation, four (40%) became capable of intravaginal ejaculation. The questionnaire evaluation showed predominant improvement after training in the ejaculation‐capable group according to the numerical rating scale, which expresses satisfaction with ejaculation. The participants experienced no significant adverse events.ConclusionAs no effective treatment currently exists for intravaginal ejaculation disorders, we conclude that the A10 Cyclone SA + PLUS may be one treatment tool for intravaginal ejaculation disorders with good efficacy and no adverse events.
Coumarin‐Pyrazole Based Fluorescent Sensor for Selective Detection of Dopamine in Aqueous Medium
Authors: Palta Aastha , Singla Dinesh , Paul Kamaldeep , Luxami Vijay 
Published: August 2023

AbstractA rapid, efficient, selective, and sensitive ratiometric chemosensor has been developed to detect dopamine. The sensor is based on coumarin fluorophore incorporating an aldehyde binding site to detect catecholamines. Here, the fluorescence quenching was observed after the reaction of compound 6 with dopamine. This fluorescence sensor relies on rapid detection of dopamine in aqueous medium by iminium ion formation between aldehyde and amine analytes at neutral pH. The reaction product gives the emission maximum at 420 nm on excitation at 280 nm. The proposed method allows the determination of dopamine upto 9.7×10−7 M. Furthermore, this method has good selectivity and sensitivity towards dopamine.
The Media in Europe 1990–2020
Authors: Papathanassopoulos Stylianos , Giannouli Iliana , Archontaki Ioanna , Karadimitriou Achilleas 
Published: August 2023

AbstractThe European media landscape has changed dramatically in the last 30 years. Initially were the privatization and commercialization of the broadcasting sector that led to an increase of TV channels and at the same time the decline of the press. The advent of the Internet has also transformed the analogue media world giving its place to the digital one. In effect, the media in Europe has undergone a prolonged period of change, in the attempt to adapt to rapid technological advances, the side effects of globalization, and the developments associated with the process of Europeanization. On the other hand, there is no simple explanation for these complex processes of change. Neither can we say that there is a common universal trend, even a common model, across Europe. This chapter tries to shed light on the emerging patterns in media production since 1990, across European countries. Initially, based on hard data, the chapter describes the changes in the media systems of the EU countries. Then it is attempted to group the similarities, continuities, and discontinuities of the media systems.
Bone mineral density around the knee after open wedge high tibial osteotomy measured up to 24 months in 51 patients
Authors: Akamatsu Yasushi , Kobayashi Hideo , Mitsuhashi Shota , Kusayama Yoshihiro 
Published: August 2023

AbstractPurposeTo evaluate bone mineral density (BMD) and radiographic and clinical outcomes of patients with varus knee osteoarthritis treated with open wedge high tibial osteotomy (OWHTO). We hypothesised that medial condyle BMD would decrease and lateral condyle BMD would increase after OWHTO.MethodsOverall, 51 patients (mean age: 65.3 years; female: 40, male: 11) treated with OWHTO were prospectively enrolled. Several angles using whole single‐leg radiographs were measured preoperatively and up to 24 months postoperatively. Five square tibial regions of interest (ROI) located below the proximal tibia as T1–T5 from medial to lateral regions and two square femoral ROI as F1 and F2 from medial and lateral regions, respectively, were defined. M/L BMD ratio was used to define the medial‐to‐lateral condyle BMD ratio. Femoral condyle BMD (F1 and F2) around the knee, as well as lumbar spine, and ipsilateral and contralateral femoral neck BMD, were measured before OWHTO and 3, 6, 12 and 24 months after OWHTO using dual‐energy X‐ray absorptiometry. Furthermore, tibial condyle BMD (T1–T5) around the knee was measured before and 24 months after OWHTO. Clinical outcomes were evaluated using the Knee Society knee and function scores, the Knee Injury and Osteoarthritis Outcome Score, and the Lysholm score preoperatively and 24 months postoperatively. A power analysis was performed.ResultsF1 BMD decreased by 19.2% from before to 3 months postoperatively. F2 BMD did not change up to 24 months after OWHTO. Femoral M/L BMD ratio decreased by 22.2% 3 months after OWHTO. T1 BMD and tibial M/L BMD ratio decreased, whilst T3, T4 and T5 BMD increased 24 months after OWHTO. Mean hip–knee–ankle angle (HKA) and weight‐bearing line ratio were corrected from − 6.8° to 4.5° and 14.7 to 60.7%, respectively, postoperatively. Lumbar spine BMD did not change up to 12 months postoperatively. Ipsilateral femoral neck BMD decreased up to 6 months after OWHTO.ConclusionMedial femoral condyle BMD decreased rapidly within 3 months and continued to decrease up to 12 months, but lateral femoral condyle BMD did not change after OWHTO. BMD measurements around the knee condyle enabled the evaluation of the changes in stress distribution before and after OWHTO with accelerated rehabilitation.Level of evidenceII.
Non-Markovian Impulse Control Under Nonlinear Expectation
Authors: Perninge Magnus 
Published: August 2023

AbstractWe consider a general type of non-Markovian impulse control problems under adverse non-linear expectation or, more specifically, the zero-sum game problem where the adversary player decides the probability measure. We show that the upper and lower value functions satisfy a dynamic programming principle (DPP). We first prove the dynamic programming principle (DPP) for a truncated version of the upper value function in a straightforward manner. Relying on a uniform convergence argument then enables us to show the DPP for the general setting. Following this, we use an approximation based on a combination of truncation and discretization to show that the upper and lower value functions coincide, thus establishing that the game has a value and that the DPP holds for the lower value function as well. Finally, we show that the DPP admits a unique solution and give conditions under which a saddle point for the game exists. As an example, we consider a stochastic differential game (SDG) of impulse versus classical control of path-dependent stochastic differential equations (SDEs).
Nomogram for predicting the prognosis of metastatic colorectal cancer patients treated with anti-PD1 therapy based on serum lipids analysis
Authors: Xiao Bijing , Ouyang Hui , Gulizeba Haimiti , Fu Haiyan , Wang Zhiqiang , Huang Yan 
Published: August 2023

Abstract
Background
Serum lipids have been identified to be used as prognostic biomarkers in several types of cancer. The primary objective of this study was to evaluate the prognostic value of serum lipids in metastatic colorectal cancer (mCRC) patients received anti-PD-1 therapy.

Methods
Pretreatment and the alteration of serum lipids, including apolipoprotein B (ApoB), apolipoprotein A-I (ApoA-I), cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) after 2 courses of anti-PD1 therapy, were collected. Kaplan–Meier survival and cox regression analysis were performed to identify the prognostic values on overall survival (OS). Finally, those significant predictors from multivariate analysis were used to construct a nomogram for the prediction of prognosis.

Results
Baseline ApoB, CHO, HDL-C, LDL-C and early changes of ApoB, ApoA-I, HDL-C were statistically significant in the ROC analysis, showing good discriminatory ability in terms of OS. In multivariate analysis, treatment lines, lung metastasis, baseline HDL-C (low vs. high, HR, 6.30; 95% CI 1.82–21.80; P = 0.004) and early changes in HDL-C (reduction vs. elevation, HR, 4.59, 95% CI 1.20–17.63; P = 0.026) independently predicted OS. The area under the time-dependent ROC curve at 1 year, 2 years and 3 years consistently demonstrated the satisfactory accuracy and predictive value of the nomogram (AUC: 0.88, 0.85, 0.84).

Conclusion
Overall, high level at baseline and an early elevation of HDL-C are correlated with better outcomes in mCRC patients treated with anti-PD1 therapy. The constructed nomogram indicated that the factors are strong predictive markers for response and prognosis to anti-PD-1 therapy in metastatic colorectal cancer.
Digital measurement of anterolateral knee laxity using strain sensors
Authors: Mayr Hermann O. , Rosenstiel Nikolaus , Prakash Karthika S. , Comella Laura M. , Woias Peter , Schmal Hagen , Seidenstuecker Michael 
Published: August 2023

Abstract
Purpose
The ambition of the research group was to develop a sensor-based system that allowed the transfer of results with strain sensors applied to the knee joint. This system was to be validated in comparison to the current static mechanical measurement system. For this purpose, the internal rotation laxity of the knee joint was measured, as it is relevant for anterolateral knee laxity and anterior cruciate ligament (ACL) injury.

Methods
This is a noninvasive measurement method using strain sensors which are applied to the skin in the course of the anterolateral ligament. The subjects were placed in supine position. First the left and then the right leg were clinically examined sequentially and documented by means of an examination form. 11 subjects aged 21 to 45 years, 5 women and 6 men were examined. Internal rotation of the lower leg was performed with a torque of 2 Nm at a knee flexion angle of 30°.

Results
Comparison of correlation between length change and internal knee rotation angle showed a strong positive correlation (r = 1, p < 0.01). Whereas females showed a significant higher laxity vs. males (p = 0.003).

Conclusions
The present study showed that the capacitive strain sensors can be used for reproducible measurement of anterolateral knee laxity. In contrast to the previous static systems, a dynamic measurement will be possible by this method in the future.
Seed amplification assay results illustrate discrepancy in Parkinson’s disease clinical diagnostic accuracy and error rates
Authors: Middleton John Stephen , Hovren Hanna Lynn , Kha Nelson , Medina Manuel Joseph , MacLeod Karen Ruth , Concha-Marambio Luis , Jensen Kendal Jay 
Published: August 2023

AbstractParkinson’s disease (PD) may be misdiagnosed due to the clinical overlap between PD and atypical parkinsonism. The utility of α-Synuclein (αSyn) Seed Amplification Assay (SAA) as a diagnostic indicator for PD has been reported in numerous studies, but never when administered as a validated clinical laboratory test. This study compares results from αSyn-SAA validation testing performed using well-characterized cohorts from two biorepositories to better understand the accuracy of PD clinical diagnosis. Blinded cerebrospinal fluid (CSF) specimens from a repository that included cohorts of subjects clinically diagnosed as PD or healthy controls, both with confirmatory dopamine transporter single-photon emission computed tomography (DAT SPECT) imaging, and blinded CSF specimens from a repository that included cohorts of subjects clinically diagnosed as PD or healthy controls based on clinical diagnosis alone, were tested as part of the validation studies for the diagnostic αSyn-SAA test (SYNTap® Biomarker Test). Measured αSyn-SAA test accuracy was 83.9% using clinical diagnosis as comparator, and 93.6% using clinical diagnosis with confirmatory DAT- SPECT imaging as comparator. The statistically significant discordance between accuracy determinations using specimens classified using different diagnostic inclusion criteria indicates that there is some symbiosis between dopamine-weighted imaging and αSyn-SAA results, both of which are associated with higher accuracy compared with the clinical diagnosis alone.
Fall-related ocular trauma in patients over 90 years in tertiary ophthalmic center in Germany: 90-TOSG Report 1
Authors: Uzel Ayşe Güzin Taşlıpınar , Gosheva Mariya , Neubauer Jonas , Stock Lydia , Bartz-Schmidt Karl-Ulrich , Gelisken Faik ,   for the 90-Tübingen Ophthalmology Study Group, Bartz-Schmidt Karl-Ulrich , Dimopoulos Spyridon , Gelisken Faik , Gosheva Mariya , Neubauer Jonas , Stock Lydia , Strudel Lisa Vanessa , Rohrbach Jens Martin , Uzel Ayşe Güzin Taşlıpınar , Ziemssen Focke 
Published: August 2023

Abstract
Purpose
To investigate the clinical characteristics of fall-related ocular trauma in patients over 90 years of age.

Methods
Retrospective, medical record reviews. Patients over the age of 90 years treated in a tertiary center with fall-related ocular trauma were included in the study.

Results
Fifty consecutive patients (fifty eyes) were analyzed. The mean age was 93.6 ± 1.8 years and 41 patients (82%) were female. The most common site of the injuries was orbital fracture (18 patients, 36%), accompanied with open globe rupture (OGR) in three patients, and globe contusion in two patients. Seventeen patients (34%) presented with OGR. Ocular trauma score in those patients was category 1 in 10 patients (58.8%) and category 2 in the others. Conjunctival hemorrhage and/or periocular contusion was seen in 14 patients (28%) and globe contusion in six patients (12%). At the presentation, the mean best corrected visual acuity (BCVA) was 2.82 ± 0.24 logMAR in patients with OGR and 1.98 ± 0.81 logMAR in six patients with globe contusion. Three of the patients with OGR had a final vision of 20/200 or better whereas the remaining patients had hand movements or less. The most common risk factors were female gender (82%) and use of antihypertensive drugs (46%).

Conclusion
Patients with OGR had a poor visual outcome despite the early treatment. It is important to raise public awareness about of the poor prognosis of ocular injuries due to falls in the elderly population in order to establish preventive measures.