bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable remission after ileocolic resection for Crohn’s disease is achievable in selected patients. Long-term results of a prospective multicentric cohort study of the GETAID Chirurgie
Authors: Abdalla Solafah , Benoist Stéphane , Maggiori Léon , Lefèvre Jérémie H , Denost Quentin , Cotte Eddy , Germain Adeline , Beyer-Berjot Laura , Desfourneaux Véronique , Rahili Amine , Duffas Jean-Pierre , Pautrat Karine , Denet Christine , Bridoux Valérie , Meurette Guillaume , Faucheron Jean-Luc , Loriau Jérôme , Souche François-Régis , Corte Hélène , Vicaut Éric , Zerbib Philippe , Panis Yves , Brouquet Antoine 
Published: January 2025

Abstract

Background and aims
Postoperative recurrence requiring medical treatment intensification or redo surgery is common after ileocolic resection (ICR) for Crohn’s disease (CD). This study aimed to identify a subgroup of CD patients for whom ICR could achieve durable remission.

Methods
This retrospective follow-up study analyzed 592 CD patients who underwent ICR (2013-2015) in a nationwide prospective cohort. Patients with &gt;36 months follow-up were included. Primary outcome was durable remission, defined as the absence of endoscopic recurrence and/or medical treatment intensification. Uni- and multivariate analyses identified predictive factors for durable remission.

Results
Among 268 included patients, 59% had B2 phenotype, 70% had a first ICR, and 66% had postoperative medical treatment. After a median follow-up of 85 (36-104) months, 52 patients (19%) experienced durable remission, of whom 24 (46%) didn’t require medical treatment and 28 (54%) maintained the same postoperative treatment, including anti-tumor necrosis factor in 15/28 patients (54%). Surgery could stabilize the disease course in 112 patients (41.7%), including 22.4% endoscopic recurrence that didn’t require CD treatment initiation or intensification. Durable remission rate was significantly increased in B1 phenotype vs B2/B3 (n = 7/18;39% vs n = 45/250;18%, P = .030) and in first ICR vs redo ICR (n = 43/184;23% vs n = 9/80;11%, P = .023). In multivariate analysis, B1 phenotype was the only independent predictive factor for durable remission (odds ratio = 3.59, IC 95%, 1.13-11.37, P = .030).

Conclusions
Surgery for CD achieved durable remission in 20%, rising to 40% in those with a B1 phenotype. These results support surgery as a viable alternative to medical treatment, offering treatment-free durable remission and preserving medical treatment options.
Robustify and tighten the lee bounds: A sample selection model under stochastic monotonicity and symmetry assumptions
Authors: Okamoto Yuta 
Published: January 2025

Abstract
In the presence of sample selection, Lee’s (2009) nonparametric bounds are a popular tool for estimating a treatment effect. However, the Lee bounds rely on the monotonicity assumption, whose empirical validity is sometimes unclear. Furthermore, the bounds are often regarded to be wide and less informative even under monotonicity. To address these issues, this study introduces a stochastic version of the monotonicity assumption alongside a nonparametric distributional shape constraint. The former enhances the robustness of the Lee bounds with respect to monotonicity, while the latter helps tighten these bounds. The obtained bounds do not rely on the exclusion restriction and can be root-n consistently estimable, making them practically viable. The potential usefulness of the proposed methods is illustrated by their application to experimental data from the after-school instruction programme studied by Muralidharan, Singh, and Ganimian (2019).
Atrial fibrillation screening and clinical outcomes: a meta-analysis of randomized controlled trials
Authors: Nyaga Ulrich Flore , Kamtchum-Tatuene Joseph , Nouthe Brice , Nkoke Clovis , Noubiap Jean Jacques 
Published: January 2025

Abstract

Background
Recommendations on atrial fibrillation (AF) screening by various scientific societies are inconsistent due to uncertainty about its benefit. This study aimed to summarize data from randomized controlled trials (RCTs) on the impact of AF screening on thromboembolism, major bleeding, and mortality.

Methods and results
We searched PubMed/MEDLINE and Embase to identify studies providing relevant data through 5 September 2024. Risk ratios (RRs) for each reported outcome of interest were pooled through a meta-analysis with random effects models. We included six RCTs reporting data from 74 145 individuals. AF screening was associated with higher AF detection compared with no intervention [RR 2.54, 95% confidence interval (CI): 1.57–4.11, P &lt; 0.001], and more common initiation of oral anticoagulation (RR 2.19, 1.51–3.18, P &lt; 0.001). Incident ischaemic stroke (RR 0.93, 0.87–1.00, P = 0.048) and thromboembolism including ischaemic stroke, transient ischaemic attack, or systemic embolism (0.93, 95% CI: 0.87–0.99, P = 0.026) were less frequent in individuals who underwent AF screening vs. controls. There was no difference for major bleeding, (RR 0.99, 95% CI: 0.93–1.06, P = 0.830), haemorrhagic stroke (RR 0.94, 95% CI: 0.80–1.11, P = 0.497) and all-cause mortality (RR 0.99, 95% CI: 0.95–1.02, P = 0.411).

Conclusion
AF screening might be beneficial, especially in reducing thromboembolic events.
Parental exposure of the freshwater snail Planorbella pilsbryi to copper results in transgenerational effects in offspring
Authors: Osborne Rebecca K , Gillis Patricia L , Prosser Ryan S 
Published: January 2025

Abstract
Although not assessed in standard ecotoxicological tests, exposure to a toxicant that does not result in an observable adverse effect in the parents may lead to transgenerational effects. These are adverse effects observed in unexposed offspring as a result of their parents’ exposure to a toxicant. The goal of this study was to investigate whether transgenerational effects are observed in freshwater snails exposed to a toxicant. Using copper (Cu) as a reference toxicant, this study investigated whether the magnitude of exposure to the parents of the freshwater snail Planorbella pilsbryi resulted in a change in sensitivity of juvenile snails to a subsequent aqueous exposure of Cu. This study also investigated whether transgenerational effects observed in juvenile snails born to exposed parents would change if the parents laid eggs after being given time to recover from their exposure to Cu. Juvenile snails born to parents that were exposed to Cu without being given time to recover had no change in their sensitivity to Cu exposure or in some cases they became less sensitive. This study also observed that when parents were given time to recover from the Cu exposure, juvenile snails tended to be more sensitive to a subsequent Cu exposure, that is, decrease in median lethal concentrations for juveniles with an increase adult exposure. This study demonstrates that exposure of parent snails to a toxicant does not necessarily result in a consistent and significant change in sensitivity of the offspring to the same toxicant.
Effects of a novel estrogenic perfluoroalkyl substance on reproductive endocrinology and function in the fathead minnow (Pimephales promelas)
Authors: Ankley Gerald T , Jensen Kathleen M , Cavallin Jenna E , Baettig Camille , Balgooyen Sarah , Blackwell Brett R , Blanksma Chad A , Collins Jacob , Ellman Michael , Hoang John , Kahl Michael D , Santana-Rodriguez Kelvin , Schaupp Christopher M , Stacy Emma , Villeneuve Daniel L 
Published: January 2025

Abstract
Effects data are lacking for the majority of poly- and perfluoroalkyl substances (PFAS). Recent in vitro work with around 140 data-poor PFAS showed that several could affect signaling pathways associated with estrogen receptor-α (ER). Subsequent short-term gene expression studies with adult male fathead minnows (Pimephales promelas) using a subset of the ER-active PFAS confirmed their estrogenic properties in vivo. Herein, we evaluated the effects of the most potent of these, 1H, 1H, 10H, 10H-perfluorodecane-1,10-diol (FC10-diol), in a multi-endpoint fathead minnow reproduction assay designed for endocrine-disrupting chemicals. Fish were exposed for 21 days to five water concentrations of FC10-diol, ranging from 0.68 to 68 µg/L, or 17β-estradiol as a positive control. Data confirmed FC10-diol as an ER agonist. Responses in males included changes in expression of four hepatic genes controlled by ER, induction of plasma vitellogenin (VTG; egg yolk protein precursor), decreased expression of male secondary sexual characteristics, histopathological changes in the testis and kidney, and mortality in the highest FC10-diol treatment group. Effects in females from the high treatment included altered ovarian expression of genes involved in steroid synthesis, decreased plasma steroids, elevated plasma VTG, histological changes in the ovary and kidney, and decreased egg production. In addition to generating baseline toxicological data, study results enabled evaluation and expansion of two adverse outcome pathways (AOPs) for predicting the effects of ER agonists in fish. One of the AOPs links activation of the ER to abnormal production of VTG, resulting in kidney dysfunction and death, whereas the second connects ER activation to altered gonadotropin signaling, resulting in decreased synthesis of maturation-inducing steroids and consequent effects on oocyte development and release.
Taking a stand, ready or not: navigating sensitive end-of-life care conversations in patients with end-stage heart failure
Authors: Róin Tóra , Jurlander Birgit , Juhl Gitte Irene , Dieperink Karin B , Sjøgren Per , Bergenholtz Heidi , Zwisler Ann-Dorthe , Kurita Geana Paula , Larsen Sille , Tønder Niels , Høyer Lene Vibe , Lykke Camilla 
Published: January 2025

Abstract

Aims
Patients with heart failure (HF) often experience delayed identification of palliative care needs. While communication with HF patients and their caregivers is increasingly stressed, systematic conversations about end-of-life care wishes remain a gap. This study explores a dyad experience of Advance Care Planning (ACP) conversations in an HF outpatient clinic.

Methods and results
A qualitative interview study with 15 patients diagnosed with end-stage HF and 14 caregivers. Through qualitative content analysis and investigator triangulation, three subthemes emerged: ‘ACP as a harsh reality’, ‘ACP as a catalyst for crucial conversations’, and ‘ACP conversations help appreciating life’s small moments and adjusting hope’. Despite significant symptom burden, many patients lacked awareness of their end-stage HF prognosis. Following an initial ‘reality shock’, ACP conversations facilitated open discussions about end-of-life care wishes. Especially spousal caregivers experienced a significant caregiving load, generating complex emotions for both patients and their families. Notably, patients prioritized self-care, daily activities, and social interaction for maintaining quality of life.

Conclusion
This study highlights a gap between patients with end-stage HF disease status and their comprehension of disease severity. Early integration of ACP may address knowledge gaps, enable informed decision-making, and alleviate caregiver burden. The study also emphasizes the patient-and family-centred care to support self-care, daily life activities, and social connections for improved quality of life throughout the disease trajectory.

Registration
ClinicalTrials.gov: NCT05269875
Comparison of blood pressure measurements between a smartphone application and the upper arm automated cuff: a prospective study with an invasive reference
Authors: Lakhal Karim , Dauvergne Jérôme E , Audran Alexia , Normand Gurvan , Rozec Bertrand , Boulain Thierry 
Published: January 2025

Abstract
Registration ClinicalTrials.gov: NCT06032169.
Population Genomics of Japanese Macaques (Macaca fuscata): Insights Into Deep Population Divergence and Multiple Merging Histories
Authors: Higashino Atsunori , Nakamura Katsuki , Osada Naoki 
Published: January 2025

Abstract
The influence of long-term climatic changes such as glacial cycles on the history of living organisms has been a subject of research for decades, but the detailed population dynamics during the environmental fluctuations and their effects on genetic diversity and genetic load are not well understood on a genome-wide scale. The Japanese macaque (Macaca fuscata) is a unique primate adapted to the cold environments of the Japanese archipelago. Despite the past intensive research for the Japanese macaque population genetics, the genetic background of Japanese macaques at the whole-genome level has been limited to a few individuals, and the comprehensive demographic history and genetic differentiation of Japanese macaques have been underexplored. We conducted whole-genome sequencing of 64 Japanese macaque individuals from 5 different regions, revealing significant genetic differentiation and functional variant diversity across populations. In particular, Japanese macaques have low genetic diversity and harbor many shared and population-specific gene loss, which might contribute to population-specific phenotypes. Our estimation of population demography using phased haplotypes suggested that, after the strong population bottleneck shared among all populations around 400 to 500 kya, the divergence among populations initiated around 150 to 200 kya, but there has been the time with strong gene flow between some populations after the split, indicating multiple population split and merge events probably due to habitat fragmentation and fusion during glacial cycles. These findings not only present a complex population history of Japanese macaques but also enhance their value as research models, particularly in neuroscience and behavioral studies. This comprehensive genomic analysis sheds light on the adaptation and evolution of Japanese macaques, contributing valuable insights to both evolutionary biology and biomedical research.
Reconciling aging and slip state evolutions from laboratory-derived canons of rate-and-state friction
Authors: Sato Dye S K , Nakatani Masao , Ando Ryosuke 
Published: January 2025

SUMMARY
The aging law and the slip law are two representative evolution laws of the rate- and state-dependent friction (RSF) law, based on canonical behaviours in three types of laboratory experiments: slide-hold-slide (SHS), velocity-step (VS) and steady-state (SS) tests. The aging law explains the SHS canon but contradicts the VS canon, and vice versa for the slip law. The later proposed composite law, which switches these two laws according to the slip rate V, explains both canons but contradicts the SS canon. This study constructs evolution laws satisfying all three canons throughout the range of variables where experiments have confirmed the canons. By recompiling the three canons, we have derived constraints on the evolution law and found that the evolution rates in the strengthening phases of the SHS and VS canons are so different that complete reconciliation throughout the entire range of variables is mathematically impossible. However, for the limited range of variables probed by experiments so far, we have found that the SHS and VS canons can be reconciled without violating the SS canon by switching the evolution function according to $\Omega$, the ratio of the state $\theta$ to its steady-state value $\theta _{\rm SS}$ for the instantaneous slip rate. We could generally show that, as long as the state evolution rate $\dot{\theta }$ depends only on the instantaneous values of V and $\theta$, simultaneous reproduction of the three canons, throughout the experimentally confirmed range, requires the aging-law-like evolution for $\Omega$ sufficiently below a threshold $\beta$ and the slip-law-like evolution for $\Omega$ sufficiently above $\beta$. The validity of the canons in existing experiments suggests $\beta \lesssim 0.01$.
The evolution of fault orientation in the 2019 Ridgecrest earthquake sequence with a new long-term catalogue of seismicity and moment tensors
Authors: Atterholt James , Wilding John D , Ross Zachary E 
Published: January 2025

SUMMARY
Throughout an earthquake sequence, perturbations to the stress field may lead to changes in the distribution of active fault orientations. Resolving such changes for narrow spatiotemporal windows requires high-quality seismicity catalogues and objective techniques to measure fault orientations. We investigate the evolution of fault orientations throughout the 2019 Ridgecrest earthquake sequence using a new seismicity catalogue that captures the sequence over several years. We generate this catalogue using a state-of-the-art workflow for event detection, absolute and relative relocation, and moment tensor inversion. With this catalogue, we measure high-resolution, time-dependent changes in the orientations of active faults using a technique from spatial statistics that quantifies anisotropic features in point processes. We evaluate the results alongside those of more standard techniques based on focal mechanisms. Near the centroid of the mainshock, we observe a substantial shift in the distribution of fault orientations, whereas to the south of the mainshock centroid, we observe only a moderate transient change in the distribution of fault orientations. Compared with results derived from focal mechanisms alone, our findings suggest a smaller background differential stress and a distinct response of the stress state to post-seismic deformation.
Illustrating the structures of bias from immortal time using directed acyclic graphs
Authors: Yang Guoyi , Burgess Stephen , Schooling Catherine Mary 
Published: January 2025

Abstract

Background
Immortal time is a period of follow-up during which death or the study outcome cannot occur by design. Bias from immortal time has been increasingly recognized in epidemiological studies. However, the fundamental causes and structures of bias from immortal time have not been explained systematically.

Methods
We use an example ‘Does winning a Nobel Prize prolong lifespan?’ for illustration. We illustrate how immortal time arises and present structures of bias from immortal time using directed acyclic graphs that specify time-varying variables. We further explore the structures of bias with the exclusion of immortal time and with the presence of competing risks. We discuss how these structures are shared by different study designs in pharmacoepidemiology and provide solutions, where possible, to address the bias.

Results
The fundamental cause of immortal time is misalignment of exposure allocation and eligibility. Specifically, immortal time arises from using post-eligibility information to define exposure or using post-exposure information to define eligibility. The structures of bias from immortal time are confounding by survival until exposure allocation or selection bias from selecting on survival until eligibility. Excluding immortal time from follow-up does not fully address this confounding or selection bias, and the presence of competing risks can worsen the bias. Bias from immortal time may be avoided by aligning baseline, exposure allocation and eligibility, and by excluding individuals with prior exposure.

Conclusions
Understanding bias from immortal time in terms of confounding or selection bias helps researchers identify and thereby avoid or ameliorate this bias.
Finite element analysis of hygrothermal interactions in date palm concrete, autoclaved aerated concrete, and gypsum walls using the Künzel model under arid and hot Climate
Authors: Bendekhis Mourad , Fezzioui Naima , Benyamine Mébirika , Osra Oumr Adnan , Alkhafaji Mohammed Ayad , Dikandé Alain M , Kaid Noureddine , Menni Younes , Chamkha Ali J 
Published: January 2025

Abstract
This paper assesses the hygrothermal performance of date palm concrete (DPC), autoclaved aerated concrete (AAC), and gypsum walls for arid climates using the Künzel model and finite element method. The profiles of temperature, relative humidity, and water content were determined under different boundary conditions. Among them, DPC exhibited the highest thermal conductivity and retained more moisture; therefore, cooling occurred much faster in the case of DPC when compared with AAC and gypsum. The temperature profiles were linearly varied, humidity relative humidity profile expressed the superior hygroscopic property of DPC. These findings guide material selection for arid climates and highlight DPC for its superior thermal and moisture management.
High-Dose Inactivated Influenza Vaccine Inconsistently Improves Heterologous Antibody Responses in an Older Human Cohort
Authors: Billings W Zane , Ge Yang , Knight Jessica H , Hemme Hayley , Hammerton Savannah M , Skarlupka Amanda L , Cao Wangnan , Shen Ye , Bahl Justin , Thomas Paul G , Ross Ted M , Handel Andreas 
Published: January 2025

Abstract

Background
Older adults often mount a weak immune response to standard inactivated influenza vaccines. To induce a stronger response and better protection, a high-dose (HD) version of the inactivated Fluzone vaccine is recommended for individuals &gt;65 years of age. While better immunogenicity and protection against the vaccine strain have been shown, it is not known if the HD vaccine also induces a robust antibody response to heterologous strains.

Methods
We fit bayesian multilevel regression models to hemagglutination inhibition antibody data from an influenza vaccine cohort spanning the influenza seasons of 2013–2014 to 2021–2022. We used this model to estimate the average causal effect of obtaining the HD vaccine relative to the standard-dose vaccine.

Results
We show that while there is generally a benefit derived from the HD vaccine, the impact is small and inconsistent. For some strains, the HD vaccine might even result in less robust heterologous responses.

Conclusions
We suggest that further increases in dose might be worth investigating to help induce a stronger broad response.
Availability of pesticide-treated seeds and bird occurrence in freshly drilled onion and carrot fields in Brazil
Authors: Souza Santos Gustavo , Casallanovo Fábio , Cione Ana Paola , Artal Mariana Coletty , Felici José Paulo , Paniago Mario del Giudice , von Blanckenhagen Felix , Vallon Martin , Ludwigs Jan-Dieter , Farrelly Eamonn , Kragten Steven , Maul Jonathan D 
Published: January 2025

Abstract
Agricultural landscapes in Brazil provide habitat to various bird species, which may be exposed to pesticide-treated seeds that have not been incorporated into the soil during drilling. Understanding the dynamics and interactions between birds and drilled fields is crucial for developing sustainable farming practices that balance agricultural food production with wildlife conservation. This study focused on the attractivity of freshly drilled onion and carrot fields to birds and the potential exposure of birds to the pesticide-treated onion and carrot seeds available on the soil surface after drilling in Minas Gerais, Brazil. Bird surveys were conducted using scan sampling and point count methods to assess diversity and behavior before, on the day of drilling, and after drilling. Carrot fields showed a decrease in observed species and individuals on the day of drilling, with an increase in bird sightings after drilling. Similar trends were observed in onion fields, with the species composition changing after drilling and a significant decrease in abundance on the day of drilling. None of the species found foraging in the field after drilling were granivorous or omnivorous. Seed exposure was assessed by counting available seeds on the soil surface at different time points after drilling. Seed exposure was higher in the field border than in the field center. These findings indicate that carrot and onion fields offer limited food sources for granivore bird species probably due to low seed availability and intensive seedbed preparation. The research also suggests that freshly drilled carrot and onion crops are unattractive to foraging birds, with low seed exposure and a reduced likelihood of contact with pesticides applied as a seed treatment.