bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Semecarpus kurzii Engler from Bay Islands for oxidative DNA damage protective activity and in vitro antioxidant potential
Authors: Das Sonali , L. S. Hallur Raghavendra , Baran Mandal Asit 
Published: May 2023

Introduction and Aim: Harnessing traditional knowledge of medicinal plants is important for the betterment of mankind. We must safeguard traditional knowledge from misuse by miscreants living in modern societies and knowledge must be available in the public domain for use in drug designing in the healthcare system. Since the beginning of recorded history, Indians have used plants as a source of medicine, and their cultural past is incredibly rich. This study was conducted to evaluate the oxidative stress-induced DNA damage prevention and antioxidant potential of Semecarpus kurzii found in the Bay Islands.

Materials and Methods: The scavenging of superoxide, hydroxyl radicals, nitric oxide (NO), 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) radicals, ferric reducing power (FRAP), and lipid peroxidation inhibition activity were tested to determine antioxidant activity. DNA damage inhibition test was used to evaluate the protection against oxidative DNA damage.

Results: The S. kurzii extract showed dose-dependent scavenging of DPPH, superoxide anion, nitric oxide, hydroxyl radical and reducing power evaluated by comparing with standard antioxidants (ascorbic acid, alpha-tocopherol and BHT). However, the nitric oxide scavenging (IC50 =186.47) and superoxide scavenging (IC50 = 678.32) was more than that of DPPH (IC50 =28.03) and Hydroxyl radical (IC50 =89.10) scavenging capacity. In addition, S. kurzii extract and ascorbic acid showed lipid peroxidation inhibition activity. The extract also exhibited DNA protection which was confirmed by the DNA damage inhibition assay.

Conclusion: Our results corroborated that, the methanolic extract of S. kurzii bark has substantial antioxidant activity and DNA damage inhibition. The potential antioxidant and oxidative DNA damage preventive activity could be due to the existence of polyphenolic compounds in the S. kurzii bark.
A cross-sectional survey of platelet transfusion practices from a tertiary care center
Authors: S. D. Manjula , D. Poulami , Shastry Shamee , K. Vasanthalakshmi , Chenna Deepika 
Published: May 2023

Introduction and Aim: Platelets are precious blood components with a very short shelf life of only 5 days. Appropriate usage is essential for judicial utilization of these components. Blood utilization metrics help in assessing the demand and understanding the utilization pattern of blood components and in improving transfusion practices. This study aims to audit and evaluate the platelet transfusion metrics and to know the utilization pattern of platelet transfusion practices at our center.

Methods: This was a retrospective observational audit conducted over a period of 6 months to evaluate the transfusion requests received for platelet transfusion and to understand the utilization pattern across various specialties.

Results: Platelet transfusions were done only in about half the requests received 855/1543(55.4%) comprising 92%
of Random Donor Platelet products and in the remaining Single donor platelet were transfused. The pre-transfusion platelet counts were documented in 1007(62.26%) of the request forms received. The utilization of platelet components was highest in General Medicine (29.6% SDP, 37.23% RDP) and Medical Oncology (40.8% SDP; 30.65% RDP).

Conclusion: Training and education at regular intervals about transfusion guidelines is essential for improvement of overall patient management. A standby order for platelet transfusion requests in par with type and screen of red cell components may help in better utilization of this valuable resource.
Plasma homocysteine, serum vitamin B12 and folic acid status in newly detected schizophrenic patients of eastern India
Authors: Mehta Neelam , Jena Itishri , Ray Subhashree , Behera Sudeshna , Kumar Tripathy Subrat , Ranjan Nayak Sarthak , Singh Bratati 
Published: May 2023

Introduction and Aim: Schizophrenia is a disastrous mental disorder that causes chronic disability. Even after many years of scientific research the underlying pathophysiology of this disorder is unclear. Deficiency of vitamin-B12 and folic acid are associated with many mental disorders. Increase in homocysteine increases risk of several disorders including schizophrenia.

Materials and Methods: Plasma homocysteine, serum vitamin B12 and folic acids were measured in 30 newly diagnosed schizophrenic cases and values were compared with 50 age and sex matched controls.

Results: Plasma homocysteine was significantly increased in schizophrenic cases in comparison to controls, vitamin B12 was significantly decreased in cases in comparison to controls. Increase in homocysteine in cases showed a significant negative correlation with vitamin-B12 of cases.

Conclusion: This study proves an association between increase in homocysteine and decrease in vitamin B12 with schizophrenia.
Prevalence of tension-type headache and its correlation with sleep quality among physiotherapy and nursing students from higher education institutions in Klang valley, Malaysia, during the COVID-19 pandemic
Authors: Selvakumar Kiruthika , Wong Pak Zhui Moses 
Published: May 2023

Introduction and Aim: Previously tension-type headache (TTH) was found to be highly prevalent among the general population worldwide, but the current data available were limited. Due to the COVID-19 pandemic, many life changes occurred to adapt to the situation, students started e-learning from home and their sleep quality (SQ) might be influenced. Physiotherapy and nursing students were studied as they are rarely being studied by researchers, information about them was very limited. This study aimed to determine the prevalence of TTH, SQ and the type of correlation between the two during the COVID-19 pandemic.

Methods: A cross-sectional study was conducted by sharing the online questionnaires composed of 2 main components: (i) Questionnaire formulated from diagnosing criteria for TTH of ICHD-3 (ii) Pittsburgh Sleep Quality Index (PSQI), to PS and NS students from higher education institutions in Klang Valley, Malaysia.

Results: A total of 259 respondents were recruited in the study. The prevalence of TTH was 76.8% and SQ had a mean score of 5.12, which indicated poor SQ among PS and NS students, during the COVID-19 pandemic. Correlation between TTH and SQ was proved to be significant in this study (p=0.032, rs =0.133).

Conclusion: High prevalence of TTH and poor SQ among PS and NS students during the COVID-19 pandemic was determined. There is a weak positive correlation between TTH and SQ during COVID-19 pandemic.
Evaluation of oxidative stress in idiopathic male infertility in the Iraqi population
Authors: Muthanna Khalid Mayasah , Ibrahim Nader Mohammed , Abdulla Hussein Mahood Rasha 
Published: May 2023

Introduction and Aim: Idiopathic infertility accounts for at least 30% of all cases of infertility, and oxidative stress has been identified as a novel developing factor in idiopathic male infertility. Oxidative stress occurs when antioxidant defense mechanisms are outmatched by the creation of reactive oxygen species (ROS). The purpose of this research was to examine the impact of enzymatic antioxidants (catalase and superoxide dismutase; CAT and SOD) on sperm DNA fragmentation and associated sperm alteration in Iraqi males with idiopathic infertility.

Materials and Methods: One hundred infertile guys (50 oligozoospermia and 50 asthenozoospermia) and 50 normospermia) had their superoxide dismutase, catalase, and malondialdehyde levels tested.

Results: Our study showed that the sperm DNA fragmentation index (DFI) of patients who suffered from oligozoospermia and asthenozoospermia was higher than that of individuals who suffered from normozoospermia. Seminal plasma SOD and MDA levels were higher in infertile participants compared to controls (P < 0.001) .The concentration of CAT in the seminal plasma of oligozoospermic and asthenozoospermic men was not significantly different from that of normospermic men. DFI correlated negatively with seminal antioxidant status (SOD, CAT) and MDA, while CAT correlated positively with SOD and MDA.

Conclusion: The impacts of oxidative stress include the breakage of DNA in sperm, with lipid peroxidation being the primary cause of idiopathic male infertility. This is associated with less successful fertility outcomes in couples. According to the findings that we obtained, the sperm DNA fragmentation index as well as malondialdehyde are substantially associated with the quality of the sperm.
Impact of risk factors on the development of breast cancer in women from Kyrgyzstan
Authors: Abdyldaev Damir , Kudaibergenova Indira , Iliyazova Saltanat , Karabaeva Iana , Uzakbaeva Banur , Tagaev Tugolbai 
Published: May 2023

Introduction and Aim: Breast cancer (BC) is the world's leading oncological disease in terms of prevalence among females and accounts for 25% of all oncological diseases affecting the female population, 25% of women are from the age of 50–60 years. The aim of the study was to determine the risk factors affecting the development of BC in women from Kyrgyzstan (well–known, specific, and protective).

Methods: This is a retrospective study that analyzed medical records and outpatient records of 1024 patients with BC treated at the National Center of the Oncology and Hematology of the Ministry of Health of Kyrgyzstan from 2016–2021.

Results: Regression analysis showed that out of numerous BC risk factors, only five factors are significant: spontaneous miscarriages (RR = 5.0, p<0.007), preterm birth (RR = 5.0, p<0.007), kidney disease (RR = 5.2, p<0.002), severe anemia (RR = 6.1, p<0.002) and severe postpartum bleeding (RR = 6.9, p<0.002), as indicated by a RR of 0, CI <1, and p<0.001.

Conclusion: Based on regression analysis, the presence and influence of specific risk factors for the development of BC in women from Kyrgyzstan were proved: spontaneous miscarriages, premature birth, kidney disease, severe anemia, and severe postpartum bleeding.
Effectiveness of vestibular exercises on balance impairment in patients affected with stroke - A systematic review
Authors: S. Ranjani Janaga , S. SenthilKumar , Suganthirababu Prathap , Srinivasan Vignesh , A. Kumaresan , Alagesan Jagatheesan 
Published: May 2023

Introduction and Aim: The patients who have been suffered with stroke have severe balance problems, it is difficult to tell with certainty how balance performance in stroke patients is impacted by vestibular impairment. The study's purpose was to determine if oculomotor and gaze stability exercises may help post-stroke individuals improve their balance.

Materials and Methods: This study includes all articles of various databases from 2000 to 2020 was included for study selection. The google scholar, research gate databases were comprehensively studied. 100 articles were searched and out of which 60 articles were selected to be assessed for eligibility in full text. Finally, 9 articles were chosen for inclusion and for analysis, although 7 of them did not match our proposed inclusion criteria.

Results: Exercises for the vestibular system have been demonstrated to be effective for stroke patients whose balance has been compromised.

Conclusion: The study finds that more high -quality experimental research on vestibular exercises and balance impairment after stroke is necessary because there is very little evidence from earlier experimental studies to draw firm conclusions about their effects.
BIOENERGY BASE OF RURAL AREAS IN THE CONTEXT OF THE FOREST COMPLEX DEVELOPMENT STRATEGY (BY THE EXAMPLE OF THE SVERDLOVSK REGION)
Authors: Мехренцев А.В. , Добрачев А.А. , Уразова А.Ф. , Кашников Г.В. 
Published: May 2023

Развитие сельскохозяйственного производства и сельских поселений посредством развития энергетики лесных территорий с использованием древесных отходов является актуальной проблемой. Поскольку сельские населенные пункты в Свердловской области, как правило, находятся на лесных территориях, то целесообразно проблемы развития сельского хозяйства и лесной промышленности, социального развития уральских деревень решать комплексно. Лес при таком подходе является источником местных строительных материалов, а отходы лесопереработки местных предприятий и низкосортная древесина будут служить дешевым и экологически чистым топливом для получения тепловой и электрической энергии. Стратегией развития лесного комплекса Российской Федерации до 2030 г. предусматривается, что в многолесных районах продолжится работа по осуществлению теплоснабжения сельских поселений с использованием лесных ресурсов, созданию в лесопромышленных организациях производства альтернативных видов топлива на основе древесных отходов. В работе дано технико-экономическое обоснование развития биоэнергетических технологий в сельской местности на территории Свердловской области
The development of agricultural production and rural settlements through the development of energy of forest areas with the use of wood waste is an urgent problem. Since rural settlements in the Sverdlovsk region, as a rule, are located in the forest areas, it is advisable to solve the problems of agricultural and forest industry development and social development of the Ural villages in an integrated manner. The forest is a source of local construction materials, and wood waste from local companies and low-grade timber will serve as a cheap and environmentally friendly fuel for heat and electricity production. The strategy of development of forestry complex of the Russian Federation until 2030 provides that in multi-forest areas will continue work on the implementation of heating in rural settlements with the use of forest resources, the creation of the forest industry organizations to produce alternative fuels based on wood waste. The paper provides a feasibility study for the development of bio-energy technologies in rural areas in the Sverdlovsk region.
ANALYSIS OF THE MACRO AND MICRO DETERMINANTS OF PROFITABILITY OF DEPOSIT MONEY BANKS IN NIGERIA
Authors: ONUORAH, A.C. (PhD; F, CIFIAN)  
Published: May 2023

The study examines the determinants of deposit money banks (DMBs) profitability in Nigeria between the periods of 2001-2017. The determinants (internal and external) are Nonperforming Loans (NPLs), Capital Adequacy (CA), Inflation Rate (INFLR), Interest Rate (INTR) and Gross Domestic Product (GDP)) while profitability was proxied with Return on Asset (ROA). The study made used of secondary data that which was sourced from the CBN Statistical Bulletin, CBN Bank Supervisory Annual Report and NDIC Annual Reports. Analysis employed descriptive statistics and correlation matrix. The Multiple Regression Model with SPSS 23 was used to determine if the independent factors and dependent variable have a significant relationship. The findings suggest that NPLs, CA and GDP have significant influence on ROA except NFLR and INTR that is insignificant. Finally, the study concluded that NPLs, CA and GDP are determinants of banks profitability in Nigeria.
Keywords: Profitability, Capital Adequacy, Interest Rate, Inflation Rate and Return on Asset.
Dansgaard–Oeschger events in climate models: review and baseline Marine Isotope Stage 3 (MIS3) protocol
Authors: Malmierca-Vallet Irene , Sime Louise C. ,   the D–O community members
Published: May 2023

Abstract. Dansgaard–Oeschger (D–O) events, millennial-scale climate oscillations between stadial and interstadial conditions (of up to 10–15 ∘C in amplitude at high northern latitudes), occurred throughout the Marine Isotope Stage 3 (MIS3; 27.8–59.4 ka) period. The climate modelling community up to now has not been able to answer the question of whether our climate models are too stable to simulate D–O events. To address this, this paper lays the ground-work for a MIS3 D–O protocol for general circulation models which are used in the International Panel for Climate Change (IPCC) assessments. We review the following: D–O terminology, community progress on simulating D–O events in these IPCC-class models (processes and published examples), and evidence about the boundary conditions under which D–O events occur. We find that no model exhibits D–O-like behaviour under pre-industrial conditions. Some, but not all, models exhibit D–O-like oscillations under MIS3 and/or full glacial conditions. Greenhouse gases and ice sheet configurations are crucial. However most models have not run simulations of long enough duration to be sure which models show D–O-like behaviour, under either MIS3 or full glacial states. We propose a MIS3 baseline protocol at 34 ka, which features low obliquity values, medium to low MIS3 greenhouse gas values, and the intermediate ice sheet configuration, which our review suggests are most conducive to D–O-like behaviour in models. We also provide a protocol for a second freshwater (Heinrich-event-preconditioned) experiment, since previous work suggests that this variant may be helpful in preconditioning a state in models which is conducive to D–O events. This review provides modelling groups investigating MIS3 D–O oscillations with a common framework, which is aimed at (1) maximising the chance of the occurrence of D–O-like events in the simulations, (2) allowing more precise model–data evaluation, and (3) providing an adequate central point for modellers to explore model stability.
The extremely hot and dry 2018 summer in central and northern Europe from a multi-faceted weather and climate perspective
Authors: Rousi Efi , Fink Andreas H. , Andersen Lauren S. , Becker Florian N. , Beobide-Arsuaga Goratz , Breil Marcus , Cozzi Giacomo , Heinke Jens , Jach Lisa , Niermann Deborah , Petrovic Dragan , Richling Andy , Riebold Johannes , Steidl Stella , Suarez-Gutierrez Laura , Tradowsky Jordis S. , Coumou Dim , Düsterhus André , Ellsäßer Florian , Fragkoulidis Georgios , Gliksman Daniel , Handorf Dörthe , Haustein Karsten , Kornhuber Kai , Kunstmann Harald , Pinto Joaquim G. , Warrach-Sagi Kirsten , Xoplaki Elena 
Published: May 2023

Abstract. The summer of 2018 was an extraordinary season in climatological terms for northern and central Europe, bringing simultaneous, widespread,
and concurrent heat and drought extremes in large parts of the continent
with extensive impacts on agriculture, forests, water supply, and the
socio-economic sector. Here, we present a comprehensive, multi-faceted
analysis of the 2018 extreme summer in terms of heat and drought in central
and northern Europe, with a particular focus on Germany. The heatwave first
affected Scandinavia in mid-July and shifted towards central Europe in late
July, while Iberia was primarily affected in early August. The atmospheric
circulation was characterized by strongly positive blocking anomalies over
Europe, in combination with a positive summer North Atlantic Oscillation and a double jet stream configuration before the initiation of the heatwave. In terms of possible precursors common to previous European heatwaves, the Eurasian double-jet structure and a tripolar sea surface temperature anomaly over the North Atlantic were already identified in spring. While in the early stages over Scandinavia the air masses at mid and upper levels were often of a remote, maritime origin, at later stages over Iberia the air masses
primarily had a local-to-regional origin. The drought affected Germany the
most, starting with warmer than average conditions in spring, associated
with enhanced latent heat release that initiated a severe depletion of soil
moisture. During summer, a continued precipitation deficit exacerbated the
problem, leading to hydrological and agricultural drought. A probabilistic
attribution assessment of the heatwave in Germany showed that such events of prolonged heat have become more likely due to anthropogenic global warming. Regarding future projections, an extreme summer such as that of 2018 is expected to occur every 2 out of 3 years in Europe in a +1.5 ∘C warmer world and virtually every single year in a +2 ∘C warmer world. With such large-scale and impactful extreme events becoming more frequent and intense under anthropogenic climate change, comprehensive and multi-faceted studies like the one presented here quantify the multitude of their effects and provide valuable information as a basis for adaptation and mitigation strategies.
Design Thinking Skills for Senior Managers From Business and Technology Perspectives
Authors: Alshehhi Abdullah , Alnaqbi Khaled , El Khatib Mounir , Aljaberi Mohamed 
Published: May 2023

Abstract
Introduction: Design thinking is regarded as a non-linear iterative process that is applied in a bid to understand users, identify problems and develop innovative solutions to problems. The concept of design thinking has attracted interest from professionals across sectors. Although design thinking has been traditionally applied by design professionals the tool has proved effective in managing organizations. Several leading businesses have reported having applied design thinking to achieve organizational success. The strategy is emerging as a critical tool for businesses seeking to advance their competitive strategy.
Purpose: The paper seeks to create an understanding of the concept of design thinking and how it is applied in business management. Consequently, the paper seeks to analyze the advantages and disadvantages of design thinking in relation to enhancing business performance.
Methodology: This section outlines the techniques that will be used in collecting information. The study will make use of interviews from business leaders and professionals in the field. Questionnaire is used as a guide for undertaking the interviews. Qualitative and quantitative analysis is be used in analyzing the data obtained.
Discussion: Design thinking has been an instrumental strategy in promoting business success. Business leaders are benefiting from the application of this strategy in realizing success for their organizations. However, the strategy has not received much appreciation from small organizations and hence suggested as a turnaround concept in business performance.
Conclusion: The findings successfully answer the question regarding the pros and cons of applying design thinking strategy in business. The study finds that design thinking is a contributing factor to business success and hence a concept that should be applied in facilitating business operations.
Key words: Design thinking, design-led professional, Technology perspective, Business perspective