bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Chronic Postsurgical Pain after Upper Extremity Surgery and its Correlation with Preoperative Pain
Authors: Droog Wouter , Coert J. Henk , Walbeehm Erik T. , Stolker Robert Jan , Galvin Eilish M. 
Published: April 2023

Background:
The incidence of chronic postsurgical pain (CPSP) after upper extremity surgery is not known. The goal was to study CPSP at 5 years postoperative and to investigate patient, surgical, and anesthetic risk factors.

Methods:
Patients scheduled for elective upper extremity surgery were included, and numeric rating scale (NRS) score for pain was obtained preoperatively and at 5 years postoperatively. According to the International Association for the Study of Pain definition, CPSP was defined as an increase in NRS compared with preoperatively.

Results:
A total 168 patients were contacted at 5 years postoperatively. Incidence of CPSP was 22%, and 35% had an NRS score of 4 or more. The number of patients with an NRS score of 0 and with an NRS score of 4 or more preoperatively was higher in the no-CPSP group, with P values of 0.019 and 0.008, respectively. Of the patients with no preoperative pain, 34% developed CPSP. Regional anesthesia was associated with a lower CPSP incidence (P = 0.001) and was more frequently applied in surgery on bony structures and in patients with a preoperative NRS score of 4 or more.

Conclusions:
The incidence CPSP was 22%. Patients with no pain or an NRS score of 4 or more preoperatively were less likely to develop CPSP, but individual susceptibility to pain and success of the surgery may be of influence. One-third of the patients with no preoperative pain developed CPSP. More studies are needed to reveal the exact relation between brachial plexus anesthesia and CPSP.
Outcomes of Partial Versus Complete Goniotomy With or Without Phacoemulsification for Primary Open Angle Glaucoma: A Multicenter Study
Authors: Song Yunhe , Zhu Xiaomin , Zhang Yao , Shu Jing , Dang Guangfu , Zhou Wenzong , Sun Lu , Li Fei , Lin Fengbin , Zhang Yingzhe , Liang Xiaohong , Wang Zhenyu , Zhang Yi , Zhang Yu , Chen Weirong , Zeng Liuzhi , Tang Li , Xie Lin , Lam Dennis S.C. , Wang Ningli , Barton Keith , Weinreb Robert N. , Zhang Xiulan ,   PVP study group
Published: April 2023

Précis:
Goniotomy (GT) 120 degrees with or without phacoemulsification was sufficient to lower the intraocular pressure (IOP) and reduce hyphema for primary open angle glaucoma.

Purpose:
To compare the surgical outcomes and safety profiles of 120 degrees and 360 degrees GT with or without phacoemulsification cataract extraction and intraocular lens implantation (PEI) for primary open angle glaucoma.

Patients and Methods:
This multicenter retrospective study consisted of 139 eyes and was divided into 4 groups: (1) 120 degrees GT, (2) 360 degrees GT, (3) PEI + 120 degrees GT, and (4) PEI + 360 degrees GT. IOP, number of topical hypotensive medications, and complications were recorded and evaluated at baseline and at the final visit. The complete and qualified success rate and their potential associated factors were also investigated. The effectiveness and safety profile of the surgery were compared between different subgroups.

Results:
After a mean follow-up of 8.6 months, the IOP reduction was 13.2 ± 8.3 (38.8 ± 28.8%), 12.4 ± 8.3 (41.6 ± 18.2%), 12.8 ± 9.9 (39.4 ± 34.5%), and 13.8 ± 7.2 (46.0±17.1%) mm Hg in 120 degrees, 360 degrees, PEI + 120 degrees GT group, and PEI + 360 degrees GT, respectively. No significant difference was found in IOP, a decline of IOP from baseline, topical hypotensive medication, and complete or qualified success between either standalone 120 degrees versus 360 degrees GT, or PEI + 120 degrees versus PEI + 360 degrees GT (all Ps > 0.05). The PEI + 120 degrees GT group had a lower final IOP than the 120 degrees GT group (P = 0.0002) whereas there was no difference between PEI + 360 degrees GT and 360 degrees GT group (P = 0.893). Both 360 degrees GT and PEI + 360 degrees GT group had a significantly higher incidence of hyphema than the 120 degrees GT and PEI + 120 degrees GT groups (all Ps < 0.0001).

Conclusions:
GT of 120 or 360 degrees lowered IOP equally with or without cataract surgery, and hyphema was most commonly noted after complete GT. Partial GT alone or in combination with cataract surgery was an effective and safe approach to manage patients with open angle glaucoma.
The Role of Mean Platelet Volume in Multisystem Inflammatory Syndrome in Children With Cardiac Manifestations
Authors: Erdede Özlem , Sari Erdal , Külcü Nihan U. , Sezer Yamanel Rabia G. 
Published: April 2023

Background:
Multisystem inflammatory syndrome in children (MIS-C) is a novel pediatric disorder associated with coronavirus disease 2019. However, no laboratory parameters can diagnose MIS-C. This study aimed to determine the changes in mean platelet volume (MPV) and investigate its relationship with cardiac involvement in MIS-C.

Methods:
In this single-center retrospective study, 35 children with MIS-C, 35 healthy children and 35 febrile children were enrolled. Patients with MIS-C were further subdivided depending on the presence of cardiac involvement. For all patients, the white blood cell, absolute neutrophil, absolute lymphocyte, platelet counts, MPV and C‐reactive protein levels were recorded. Ferritin, D-dimer, troponin and CK-MB levels and the day when IVIG was administered were recorded and compared between groups.

Results:
Thirteen patients with MIS-C had cardiac involvement. The mean MPV of the MIS-C group was significantly higher than those of the healthy (P = 0.0001) and febrile (P = 0.027) groups. Using a cutoff of >7.6 fL, the MPV had a sensitivity of 82.86% and specificity of 82.75%, and the area under the MPV receiver operating characteristics curve was 0.896 (0.799–0.956). The MPV was significantly higher in patients with cardiac involvement than in those without (P = 0.031). Logistic regression analysis revealed that the association between the MPV and cardiac involvement was significant (odds ratio, 2.28; 95% confidence interval, 1.04–2.95; P = 0.039).

Conclusions:
The MPV may indicate cardiac involvement in patients with MIS-C. Large cohort studies are needed to define an accurate cutoff value for the MPV.
Unlocking Population-Specific Treatments to Render Equitable Approaches and Management in Cardiovascular Disease
Authors: Smith Shannon Bright , Abshire Demetrius A. , Magwood Gayenell S. , Herbert Laura L. , Tavakoli Abbas S. , Jenerette Coretta 
Published: April 2023

Background
Emerging adulthood (18–25 years old) is a distinct developmental period in which multiple life transitions pose barriers to engaging in healthy lifestyle behaviors that reduce cardiovascular disease risk. There is limited theory-based research on African American emerging adults.

Objective
This article introduces a synthesized empirically testable situation-specific theory for cardiovascular disease prevention in African American emerging adults.

Methodology
Im and Meleis' integrative approach was used to develop the situation-specific theory.

Results
Unlocking Population-Specific Treatments to Render Equitable Approach and Management in Cardiovascular Disease is a situation-specific theory developed based on theoretical and empirical evidence and theorists' research and clinical practice experiences.

Discussion
African American emerging adults have multifaceted factors that influence health behaviors and healthcare needs. Unlocking Population-Specific Treatments to Render Equitable Approaches and Management in Cardiovascular Disease has the potential to inform theory-guided clinical practice and nursing research. Recommendations for integration in nursing practice, research, and policy advocacy are presented. Further critique and testing of the theory are required.
Alpha, Beta, and Gamma Human Papillomaviruses in Genital Lichen Sclerosus: A Retrospective Cross-Sectional Study
Authors: Giuliani Eugenia , Rollo Francesca , Cota Carlo , Gheit Tarik , Galati Luisa , McKay-Chopin Sandrine , Tedesco Marinella , Migliano Emilia , Benevolo Maria , Morrone Aldo , Donà Maria Gabriella , Latini Alessandra 
Published: April 2023

Background
Lichen sclerosus (LS) is an inflammatory disease mostly arising at the genital level. It is unclear whether human papillomaviruses (HPVs) have an etiological significance in LS, and data on their prevalence in patients with LS are controversial.

Objectives
The authors assessed alpha, beta, and gamma HPV prevalence in patients with genital LS. The association of HPV positivity with demographic and clinical factors was also investigated.

Methods
One hundred thirty-two formalin-fixed, paraffin-embedded LS samples (2016–2020) were retrieved from the archives of a pathology department. Alpha HPVs were genotyped with the INNO-LiPA HPV Genotyping Extra II kit. Beta and gamma HPVs were searched by multiplex Polymerase Chain Reaction. Immunostaining for p16INK4a was performed on high-risk HPV-positive samples.

Results
Patients had a median age of 61 years, were mostly women (n = 73, 55.3%), and with an early disease stage (n = 79, 59.8%). Alpha HPVs were detected in 12/132 cases (9.1%). Among the 5 high-risk HPV-positive cases, only 2 displayed a strong and diffuse p16INK4a staining. Beta genus was the most prevalent (35/132, 26.5%) and HPV5 was the most frequent beta genotype (25/132, 18.9%). There were 3 gamma HPV-positive cases among those with a valid result (3/131, 2.3%). Multiple infections with genotypes belonging to different genera were infrequent (3/131, 2.3%). No significant differences in the prevalence of the individual genera were observed according to sex and disease stage.

Conclusions
Of the 3 HPV genera, beta genus showed the highest prevalence. Further research is needed to clarify whether the presence of beta HPVs in genital LS has a clinical significance.
“Most efficient and meaningful patient reported appearance assessment in different cleft types and age-groups with Cleft-Q”
Authors: Ombashi Saranda , Kurniawan Melissa S.I.C. , Koudstaal Maarten J. , Allori Alexander C. , Jansson Kristina , Rogers-Vizena Carolyn R. , Mathijssen Irene M.J. , Klassen Anne F. , Versnel Sarah L. 
Published: April 2023

BACKGROUND:
The CLEFT-Q, a questionnaire developed and validated specifically for cleft patients, contains 7 ‘appearance’ scales. The ICHOM (International Consortium of Health Outcomes Measurement) has incorporated only some Cleft-Q ‘appearance’ scales in the Standard Set to minimize burden. This study evaluates which ‘appearance’ scales provide the most meaningful information in the different cleft types at specific ages, for the most efficient cleft appearance outcome assessment.

METHODS:
Within this international multicentre study, outcomes of the 7 appearance scales were collected, either as part of the ICHOM Standard Set, or as part of the field test study performed to validate the CLEFT-Q. Analyses were done in separate age-groups and cleft types, and involved univariate regression analyses, trend analyses, T-tests, correlations, and floor and ceiling effects.

RESULTS:
A total of 3116 patients were included. Scores for most appearance scales showed a downward trend by age-groups, with the exception of the Teeth and Jaw scales. In all cleft types, several scales correlated strongly with each other. No floor effects were observed, but ceiling effects were found in several scales in different age-groups, most often in the CLEFT-Q Jaw.

CONCLUSION:
A proposition for the most meaningful and efficient appearance outcome assessment in cleft patients is made. It was composed so that recommendations are of value for different cleft protocols and initiatives. Suggestions for the use of scales in the ICHOM Standard Set at different ages are given, also from a clinical perspective. Use of the CLEFT-Q Scar, Lips, and Nose, will provide additional relevant information.
Development of a prosthetic fit and alignment assessment (ProFit) in persons with post-traumatic transtibial amputation
Authors:   Major Extremity Trauma Research Consortium (METRC)
Published: April 2023

Background:
There are no standards for reliably measuring the quality of prosthetic fit and alignment which is important for evaluation and improvement of clinical care for patients with transtibial amputation.

Objectives:
The purpose of this study was to develop an instrument to quantitatively assess prosthetic fit and alignment in patients with transtibial amputation.

Study Design:
Prospective cohort study.

Methods:
The fit and alignment assessment (ProFit) included 39 items for assessments of skin quality, stance and gait, and radiographic characteristics that could be feasibly captured in clinic using photographs, video, and radiographs. Data were collected on adults aged 18–60 years treated with transtibial amputation and followed up for 18 months at 1 of 27 US hospitals. One hundred thirteen assessments were conducted by 6 prosthetists using an online platform. Items demonstrating reliability and face validity were included in the ProFit score for subsequent validation testing. Validation measures included 18-month patient-reported function (Short Musculoskeletal Function Assessment ), tests of physical performance, patient-reported pain (Brief Pain Inventory ), satisfaction with prosthesis (Orthotics Prosthetics Users Survey), prosthesis use, and walking activity.

Results:
The ProFit score included 10 of 39 items that demonstrated high inter-rater reliability and face validity. A higher ProFit score correlated with worse function on all domains of the Short Musculoskeletal Function Assessment except arm and hand and with worse performance on the 4-Square Step Test, Shuttle Run, and Illinois Agility Test. ProFit scores did not correlate with the Brief Pain Inventory, Orthotics Prosthetics Users Survey, prosthesis use, or walking activity.

Conclusions:
The ProFit score can be used by researchers and clinicians to measure the quality of socket fit and prosthetic alignment. Future prospective validation is necessary to verify the promising results observed in ProFit development and establish clinical utility.
Para- and transcellular transport kinetics of nanoparticles across lymphatic endothelial cells
Authors: McCright Jacob , Yarmovsky Jenny , Maisel Katharina 
Published: April 2023

AbstractLymphatic vessels have received significant attention as drug delivery targets, as they shuttle materials from peripheral tissues to the lymph nodes, where adaptive immunity is formed. Delivery of immune modulatory materials to the lymph nodes via lymphatic vessels has been shown to enhance their efficacy and also improve bioavailability of drugs when delivered to intestinal lymphatic vessels. In this study we generated a three-compartment model of a lymphatic vessel with a set of kinematic differential equations to describe the transport of nanoparticles from surrounding tissues into lymphatic vessels. We used previously published data and collected additional experimental parameters, including transport efficiency of nanoparticles over time, and also examined how nanoparticle formulation affected the cellular transport mechanisms using small molecule inhibitors. This experimental data was incorporated into a system of kinematic differential equations and non-linear, least squares curve fitting algorithms were employed to extrapolate transport coefficients within our model. The subsequent computational framework produced some of the first parameters to describe transport kinetics across lymphatic endothelial cells and allows for the quantitative analysis of the driving mechanisms of transport into lymphatic vessels. Our model indicates that transcellular mechanisms, such as micro- and macropinocytosis, drive transport into lymphatics. This information is crucial to further design strategies that will modulate lymphatic transport for drug delivery, particularly in diseases like lymphedema, where normal lymphatic functions are impaired.
The common welfare human resource management system and innovativeness: the mediating role of altruism
Authors: Mallén-Broch Francisco Fermín , Chiva Ricardo , Rodríguez-Sánchez Alma , Guinot Jacob 
Published: April 2023

PurposeThe paper analyzes and develops Chiva's (2014) proposal on the common welfare HRM system and uncovers its relationship with innovativeness, using altruism as a mediator.Design/methodology/approachThe common welfare HRM system implies a certain human and organizational development of the classic control and commitment HRM systems, and its main goal is to promote innovation through a prosocial approach. To this end, the authors investigated its HRM practices, developed a measurement instrument and provided initial illustrative evidence of some of its main implications for innovativeness and altruism. They tested these relationships on a sample of 269 Spanish firms using structural equations and bootstrapping to confirm the significance of the mediated effect.FindingsResults confirm the study’s hypotheses, thus supporting the common welfare HRM system as a relevant tool for developing innovativeness through the power of altruism. This paper therefore provides empirical evidence of these relationships.Practical implicationsThis study has implications that can help managers to increase innovativeness through a specific HRM system. The findings reveal that a coherent set of HRM practices based on common welfare principles and a high level of consciousness creates a climate of altruism that results in innovativeness.Originality/valueThis research shows that humanistic HRM practices also have an impact on performance variables such as innovativeness, through altruistic employees' behaviors. It also develops a measurement instrument for the common welfare HRM system and provides some initial illustrative evidence of some of its main implications.
Facts or belief: examining the effect of the cognitive dissonance on brand switching, purchase regret and satisfaction level
Authors: Ibrahim Awwad Razan , Ibrahim Blend , George Cinoj , Hamdan Sameer , Nair Kiran 
Published: April 2023

Purpose
This study aims to investigate the relative impacts of the cognitive dissonance on brand switching (BS) and satisfaction level (SAT) by considering the mediation role of purchase regret (PRG) in these relationships in an online shopping context.

Design/methodology/approach
The data was collected from 354 participants, and structural equation modeling and mediation analysis were conducted to test the conceptual model hypotheses.

Findings
The findings revealed that the cognitive dissonance positively affects PRG. Also, the study indicated a negative and nonsignificant relationship between cognitive dissonance and SAT and a negative significant relationship between cognitive dissonance and BS. In addition, a positive and significant correlation was found between PRG and BS. Furthermore, the results revealed that PRG mediates the relationship between cognitive dissonance and SAT.

Originality/value
This research provides a novel contribution by examining the impact of the cognitive dissonance on BS and SAT and uncovering the underlying mechanism of how and under what conditions cognitive dissonance promotes BS and SAT in an online shopping context.
Virtual accreditation peer review team visits – higher education accreditations: present and future directions
Authors: Reddy J. Srikanth , Sharma Ritu , Gupta Narain 
Published: April 2023

PurposeThe main objective of the present research is to depict the experience of challenges and opportunities for virtual accreditation peer review team (PRT) visits. COVID-19 has changed higher education delivery. Higher education accreditation and PRT visits have become online. The lockdown forced schools and accreditation agencies to cancel or change visit arrangements. PRT visits could not be stopped during the COVID-19 pandemic, but accrediting agencies needed to review programme quality to meet standards.Design/methodology/approachEight former and present accreditation specialists were interviewed. The researchers described the challenges and opportunities in virtual accreditation visits (VAV). Also, the authors have explained their own experience of coordinating on-site and virtual accreditation visits. Using the NVIVO tool, the experts' replies are transcribed and categorised as challenges and opportunities.FindingsThe findings will help the professionals and academicians better prepare for, plan and execute virtual PRT visits for accreditation agencies and schools. The results revealed that the evaluation and accreditation outcomes are similar for virtual and physical accreditation visits. Finally, the findings suggest that accreditation agencies and schools need to adopt a hybrid site visit model for accreditation visits.Practical implicationsThe school can prepare better for virtual PRT visits by identifying the challenges and opportunities ahead of time. The finding may motivate authorities to schedule meetings in different time zones, prepare document evidence rooms, save money, time, and travel time, and benefit the environment by eliminating paper printing, fuel use, and paper printing.Originality/valueThis research is unique and noteworthy since accreditation organisations, PRT members and schools are uncertain about virtual visits. This may be the first paper in this domain to assist accreditation organisations and institutions review accreditation visits online or in hybrid mode.
Promoting construction for sustainability transformation: the perspective of institutional theory
Authors: Tunji-Olayeni Patience , Kajimo-Shakantu Kahilu , Ayodele Timothy Oluwafemi , Babalola Olubola 
Published: April 2023

PurposeSustainability transformation in the construction industry is vital for the attainment of sustainable development goals. While conventional construction has been at the expense of social and economic sustainability, sustainable construction can enhance environmental, social and economic outcomes for the construction industry and society at large. However, the industry struggles with new initiates because its stakeholders are products of unique institutions which shape their decisions and intentions to adopt new practices. This study assessed the institutional pressures that influence the adoption of sustainable construction to enhance our understanding of other factors that can promote and accelerate the adoption of sustainable construction.Design/methodology/approachThe study adopted a quantitative research design with the use of online questionnaires to elicit information from construction professionals in South Africa. Descriptive statistics of frequencies, mean and standard deviation were used to analyse the data obtained from the survey. Linear regression was also used to assess the influence of institutional pressures on the adoption of sustainable construction.FindingsMimetic pressures were found to have a significant influence on the adoption of sustainable construction. The decision to adopt sustainable construction was based on the sustainability actions of industry leaders (mimetic pressure). Normative and coercive pressures had no significant influence on the adoption of sustainable construction.Practical implicationsMimetic pressure from competitors and normative pressures is already exerting some pressure on stakeholders to adopt sustainable construction. However, there cannot be a long-term commitment that will yield the needed sustainability transformations without additional normative pressure from learned societies and coercive pressure from the government. As one of the pioneering works from the global south, this study provides empirical validations of the influence of institutional pressures on the adoption of sustainable construction. It also enhances understanding of how institutional pressures from the social context can promote and accelerate the adoption of sustainable construction.Originality/valueThe findings present one of the pioneering efforts to empirically validate the influence of institutional pressures on the adoption of sustainable construction.