bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alfabetização Científica a partir de uma Sequência de Ensino Investigativo (SEI) relacionada aos impactos antrópicos no ambiente
Authors: Vázquez Dandara , Nunes Garcia Rosane 
Published: January 2025

A habilidade de analisar conteúdo científico e ser capaz de entender como aquele conhecimento foi elaborado, é crucial para que cidadãos possam atuar de forma ativa e responsável na sociedade. A Alfabetização Científica (AC) possibilita que estudantes desenvolvam habilidades do saber científico, tornando-os capazes de tomar decisões cientificamente fundamentadas em seu contexto social. O objetivo desta pesquisa foi compreender como um grupo de estudantes dos anos finais do Ensino Fundamental articulam conhecimentos e desenvolvem a AC, a partir de uma Sequência de Ensino Investigativo (SEI) interdisciplinar a respeito dos impactos antrópicos no ambiente. A metodologia foi qualitativa, estruturada como uma pesquisa-ação, organizada em três etapas: aplicação de instrumento de sondagem, planejamento e desenvolvimento da SEI e análise das produções dos estudantes para avaliação da presença dos indicadores de AC. Os resultados evidenciaram que a SEI promoveu a AC ao propiciar aos estudantes vivências que os levaram a se posicionar, discutir suas concepções prévias e fundamentar seus argumentos. Houve incremento de indicadores de AC após a SEI, o que demonstrou que os estudantes estabeleceram relações entre o conhecimento teórico aprendido em sala de aula, a realidade vivida e o meio ambiente no qual estão inseridos.
Ultra‐short‐term versus short‐term measures of heart rate variability in specialist police units: A pilot reliability study
Authors: Tomes Colin D. , Canetti Elisa F. D. , Schram Ben , Orr Robin 
Published: January 2025

AbstractPolice officers are exposed to high levels of stress. Serving on Special Weapons and Tactics (SWAT) teams is a highly demanding duty that may further increase levels of stress in police personnel. This stress may accumulate, thereby increasing allostatic load. As such, holistic stress measures may be valuable for quantifying multifactorial stress accumulation in SWAT personnel. Heart rate variability (HRV) is one field‐deployable measure that may be suitable in this context. However, with logistical challenges present in this population, determining if 30 s; rather than more the typical 5‐min ECG data collection, provides sufficient reliability may be beneficial for reducing the logistical barrier to adoption of HRV monitoring in SWAT personnel. This study compared 30‐s to 5‐min HRV analyses of ECG data obtained from 15 male SWAT personnel. Findings demonstrated good (ICC >0.8) reliability only in the VLF, HF, SD1, and SD2 HRV domains. The VLF and SD2 measures may be erroneous, as 5‐min may still insufficiently characterize these measures. However, this study confirms the robust quality of nonlinear HRV analysis, as the SD1 value demonstrated the highest ICC reported here (0.902). Therefore, while 5‐min ECGs may still preferable, the 30‐s measure may still be viable for organizations considering HRV assessment.
An introduction to the distorted Fourier transform
Authors: Ko Haram , Schlag Wilhelm 
Published: January 2025

Abstract
This article is intended as an introduction to the distorted Fourier transform associated with a Schrödinger operator on the line or the half-line. This versatile tool has seen numerous applications in nonlinear PDE in recent years. It typically arises in the asymptotic stability analysis of topological solitons in classical field theory, such as kinks in the sine-Gordon or ϕ
4 models. The distorted Fourier transform is also a natural technique in the analysis of dispersive equations on manifolds with symmetries. Such models appear in general relativity, for example in the study of waves on a black-hole background. While microlocal methods have proven to be powerful in such applications, the more classical Weyl–Titchmarsh spectral theory and with it, the distorted Fourier transform, continue to play an essential role in the analysis of evolution PDEs. This article explain how it can be derived from Stone’s formula, which also establishes the Plancherel and inversion theorems.
Using Linear Positioning Transducers to Improve Snatch Performance in Weightlifters
Authors: Kozub Francis M. , Walker Ash 
Published: January 2025

ABSTRACT
This article examines how to use linear position transducers to support training for weightlifters performing the snatch. These commercially available devices provide valuable velocity data from the first pull, transition, and through the second pull, which all occur before the athlete rotating under the bar for the catch. Athletes benefit from this discussion given the need to maximize training repetitions before fatigue. Velocity data are useful in applying autoregulation principles before workouts and during training sessions. An individualized approach helps weightlifting coaches identify errors and avoid loss of velocity during key points in the lift. This includes determining each lifter's threshold velocities for successful lifts. Deviations from a successful lift/velocity profile (following a missed lift) help identify where errors occur or if fatigue is a factor. This is important to support technique in lifters who are not represented in the published studies. Examining velocity data in conjunction with video analysis provides information needed to prescribe auxiliary exercises or loads for pulling exercises to ensure that velocity loss is minimized. Velocity feedback helps lifters select loads for successful repetitions that produce a desired force profile and result in improved snatches contributing to higher totals during competition.
Reconceptualización del rol pedagógico de educadoras chilenas durante la pandemia
Authors: Romo Escudero Francisca , Pizarro Laborda Paulina , Errázuriz María Constanza 
Published: January 2025

La pandemia del COVID-19 transformó las aulas de toda la educación, incluida la educación infantil, lo que obligó que las educadoras pasaran de trabajar en el aula presencial a realizar actividades a través de una pantalla. Para comprender en mayor profundidad la labor pedagógica que realizaron las educadoras en este período, el objetivo de este estudio fue explorar y describir cómo un grupo de educadoras chilenas reconceptualizaron su rol pedagógico durante la pandemia. Para analizar cómo esta experiencia vital en su vida profesional afectó sus identidades docentes debido a una situación de emergencia, se realizaron entrevistas semiestructuradas a educadoras de kínder y prekínder de escuelas públicas chilenas y, posteriormente, se analizaron a través de la teoría fundamentada. Sus resultados manifiestan que hay tres grandes roles que identifican las educadoras: en función de la relación con las familias, en función de la toma de decisiones y en función de su identidad profesional. Se analizaron dichas funciones en torno al nivel de autoeficacia de las educadoras, que, si bien en un inicio se vio disminuido debido a los abruptos cambios que se vieron enfrentadas, finalmente fue un impulso para empoderarse y no sólo educar a niños y niñas, sino también a sus familias, quienes podían llegar de manera directa a interactuar con el niño o niña en el hogar. Los desafíos enfrentados durante la pandemia se relacionan con aspectos que afectan el trabajo de las educadoras no solo en situaciones de emergencia, como la relación con las familias. De este modo, se discute cómo lo ocurrido durante la pandemia puede tener consecuencias para el trabajo de las educadoras en condiciones de normalidad. Futuros estudios son necesarios para continuar explicando el sentido de profesionalización de las educadoras, que históricamente se ha visto aminorado por la carga de cuidado que conlleva cumplir este rol.
Computerized cognitive training for problem gambling: A randomized controlled trial (TRAIN-online)
Authors: Luquiens Amandine , Benyamina Amine , Perney Pascal , Carré Arnaud 
Published: January 2025

AbstractBackgroundNon-face-to-face interventions offer promise, with cognitive training showing potential but inconsistent efficacy in problem gambling.MethodsWe conducted a non-face-to-face, parallel, randomized, controlled, single-blinded trial to evaluate training programs in adults with problem gambling (CPGI ≥5). Participants were randomized 1:1 to a web-based cognitive training program targeting inhibition unrelated to addiction cues or a control program on visuo-spatial functioning. Both programs benefited from weekly phone calls to support engagement and transferability to daily life. A mixed community and out-patient sample was recruited at the national-level. The primary outcome was change in CPGI at week 6. Secondary outcomes were change in impulsivity, gambling behavior and quality of life at 6 and 14 weeks.Results187 participants were screened, with 185 randomized: 93 to intervention and 92 to control. No significant differences were found between groups for any outcome. Mean PGSI change at 6 weeks was −2.75, 95% CI [−12.95; 7.44] in the experimental arm versus −2.44, 95% CI [−13.52; 8.64] in controls, p = 0.76. 34% of participants were classed as no longer problem gamblers at week 14. Intervention acceptability was moderate, with 21 participants (22.58%) in the experimental group, and 32 (34.78%) controls never accessing the platform (p = 0.07).ConclusionsFurther research is needed to optimize cognitive interventions in problem gambling, to improve engagement and to demonstrate their added value beyond minimal intervention. For a number of problem gamblers, minimal telephone interventions appeared to be sufficient to reduce gambling. Objective account-based gambling data will provide valuable insights into long-term and objective effects.
Media Relations Hubungan Masyarakat Kota Bandung Menghadapi Krisis (Studi Kasus Penangkapan Wali Kota Bandung Yana Mulyana oleh Komisi Pemberantasan Korupsi)
Authors: Awal Brilliant , Perbawasari Susie , Lusiana Elnovani 
Published: January 2025

Penelitian ini bertujuan mengetahui media relation yang diyakini, dibangun, dan diimplementasikan oleh berbagai pihak terkait dengan kasus penagkapan Wali Kota Bandung, Yana Mulyana oleh Komisi Pemberantasan Korupsi. Selain itu untuk mengetahui alasan Humas Kota Bandung melaksanakan media relations. Metode yang digunakan adalah deskriptif kualitatif dengan mengumpulkan data dari para informan dan diolah secara kualitatif. Hasil penelitian menunjukkan bahwa Humas Kota Bandung telah melaksanakan media relations secara maksimal. Namun Humas Kota Bandung belum melibatkan stakeholder lain seperti pegiat antikorupsi dalam menangani kasus penangkapan Yana Mulyana oleh Komisi Pemberantasan Korupsi. Selain itu, tidak semua upaya yang dilakukan Humas Kota Bandung bisa diterima oleh media dan stakeholder lainnya. Hal itu karena media memiliki agenda tersendiri terkait pemberitaan kasus penangkapan Yana Mulyana.
Opportunities of combination therapy in reproductive age patients with bacterial vaginosis combined with vulvovaginal candidiasis
Authors: Savelieva I. V. , Bukharova E. A. , Galyanskaya E. G. , Nosova N. V. , Davydov P. V. 
Published: January 2025

Aim: to assess the effectiveness of combination therapy in reproductive age patients with mixed vaginitis.Materials and Methods. A retrospective analysis of the therapeutic effectiveness for mixed vaginitis in 158 patients aged 18 to 45 years was carried out. For treatment, the drugs Gainomax (standard dose – thioconazole 100 mg, tinidazole 150 mg in the form of a suppository) and Gainomax plus (standard dose – thioconazole 200 mg, tinidazole 300 mg, lidocaine 100 mg in the form of a suppository) were used for 3 days. The criteria for treatment effectiveness were disappearance of clinical symptoms and normalization of laboratory parameters.Results. Clinical and laboratory efficacy of therapy reached 95.6 %. Lack of therapeutic effectiveness presented as persistent complaints from patients was recorded in 7 out of 158 (4.4 %) of patients, at the same time, the normalization of vaginal pH was established (pH = 4.1 ± 0.4), the Lactobacilli count increased up to 107 ± 2.8 CFU/cm3, eradication of other opportunistic bacteria and fungi Candida occurred. No side effects were reported while assessing drug safety and tolerability.Conclusion. Therapy combining thioconazole and tinidazole in treatment of patients with mixed vaginitis demonstrated high effectiveness.
Advanced management tactics for high-risk pregnant women with moderate novel coronavirus infection COVID-19
Authors: Romanovskaya A. V. , Arzhaeva I. A. , Mikhailovskaya T. V. , Popilov M. A. 
Published: January 2025

Aim: to assess efficacy and safety of using colloidal silicon dioxide as an adjunct therapy in managing high-risk pregnant women with moderate COVID-19.Materials and Methods.  A  prospective  comparative  study  was  conducted  by  enrolling  62  pregnant  women  hospitalized  with moderate COVID-19. Metabolic charts and delivery records were subsequently reviewed. Participants were divided into two groups: Group 1 (n = 32) received standard treatment, while Group 2 (n = 30) received standard treatment plus colloidal silicon dioxide. Clinical and laboratory markers of endotoxemia, pregnancy progression, and outcomes were assessed.Results. It was found that in Group 2 vs. Group 1 mean length of the following symptoms was significantly shorter: hyperthermia – by 2.4 days (p = 0.011), tachycardia – by 2.2 days (p = 0.037), weakness – by 2.1 days (p = 0.137), and headache – by 1.7 days (p = 0.042). In addition, women from Group 2 also showed significantly lower C-reactive protein and interleukin-6 levels (p = 0.006 and p = 0.019, respectively) as well as lacked blood flow disturbances at significantly more frequent level primarily Grade 1B uteroplacental insufficiency. Grade III blood flow disturbances were observed in one patient in Group 1 but none in Group 2. Regarding delivery outcomes, 97 % of Group 1 pregnancies resulted in live births (mean body length – 49.25 ± 1.75 cm, mean birth weight – 3126 ± 245.6 g), with vacuum extraction observed in 9 % of cases and cesarean section – in 31 %. One case of antepartum fetal demise occurred. In Group 2, all pregnancies resulted in live births (mean body length – 51.5 ± 2.5 cm, mean birth weight – 3360 ± 260 g), with vacuum extraction in 3 % of cases and cesarean section – in 30 %. While some patients exhibited combinations of these parameters, no significant inter-group differences were found. Assessing neonatal condition at one minute postpartum revealed significantly more cases of mild asphyxia in Group 1; the number of newborns without asphyxia was twice as high in Group 2 (p = 0.021).Conclusion. Comparing course of pregnancy, delivery, neonatal condition, and management of high-risk pregnant women with moderate COVID-19 using the proposed methodology suggests its high efficacy and safety.
Capicua regulates the survival of Cajal-Retzius cells in the postnatal hippocampus
Authors: Tan Qiumin , Patel Zain , Bruggen Rebekah van , Wang Mi 
Published: January 2025

Abstract

Programmed cell death is crucial for organ morphogenesis and tissue homeostasis. Understanding programmed cell death in the developing brain is essential for comprehending both normal brain development and neurological disorders. In this study, we utilize Cajal-Retzius (CR) cells, transient neurons that populate the embryonic cortex and are predominantly eliminated in early postnatal stages, as a model to investigate the regulation of programmed cell death. While many CR cells typically undergo postnatal cell death, some persist into adulthood in the hippocampus, influencing local circuits and behaviors. Here, we show that the loss of capicua (CIC), a transcriptional repressor implicated in a rare neurodevelopmental syndrome and multiple cancers, results in aberrant survival of CR cells in the adult hippocampus. Altered cell survival is mediated by the cell-autonomous function of CIC in hippocampal CR cells. Surprisingly, the atypical persistence of CR cells following CIC loss does not impact hippocampal-dependent behaviors or susceptibility to kainic acid-induced seizures. Single-cell transcriptomic analysis unveils previously unrecognized heterogeneity among hippocampal CR cells and suggests a role of CIC in repressing Fgf1 expression. Additionally, we reveal that FGF1 and BCL2 serve as pivotal regulators enhancing CR cell survival in the postnatal hippocampus. Our findings shed light on a previously unacknowledged role of CIC upstream of FGF signaling and elucidate the apoptosis mechanism governing developmental programmed CR cell death.
Unmet health-related needs in patients with Crohn’s disease in Belgium: a mixed-methods study.
Authors: Schönborn Claudia , Levy Muriel , De Jaeger Mats , Goethem Renaud van , Leonard Ugo , Claerman Rani , De Pauw Robby , Kohn Laurence , Cleemput Irina , de Noordhout Charline Maertens 
Published: January 2025

Abstract

Background
Measuring health-related unmet needs is crucial for identifying innovation gaps and developing targeted strategies to address them. This study focused on measuring the unmet needs of patients with Crohn’s disease in Belgium using a standardised methodology that facilitates comparisons across different diseases. Crohn’s disease is a chronic condition characterised by a rising incidence over the past century and limited progress in understanding its causes or advancing effective treatments.
Methods
We conducted an online survey (n=150) and semi-structured interviews (n=20) with adults affected by Crohn’s disease. Descriptive statistics were used to analyse survey results, and thematic analysis was applied to interview transcripts. Unmet needs were classified into health, healthcare, and social aspects.
Results
The study revealed unmet needs beyond the well-known symptoms of Crohn’s. One in five patients waited over a year for a diagnosis, and 58% considered their treatment burdensome. While at least 75% reported diarrhoea, fatigue, and abdominal cramps as burdensome, around 40% experienced burdensome stress, anxiety, or depression. These symptoms, perceived as invisible, caused embarrassment, impacted sexual and family life, and led to social withdrawal. Psychological support was generally deemed insufficient. Only 50% returned to previous work levels, and 65% experienced financial impacts due to the disease.
Conclusions
Crohn’s patients experienced not only burdensome physical symptoms, but were also frequently affected by significant psychological symptoms, exacerbated by comorbidities, which significantly affected their quality of life. Although specialist care was adequate, faster diagnosis and better psychological support are needed. Future studies should explore the unmet needs of children and adolescents with Crohn’s disease to complete the picture.
Assessment of Depression, Anxiety, and Stress Among Epileptic Patients Utilizing the DASS-21 Scale: A Cross-Sectional Investigation
Authors: Vishwakarma Shani , Pathak Abhishek , Maurya Anil Kumar , Singh Nitish Kumar , Singh Royana 
Published: January 2025

Abstract

Introduction
People with epilepsy frequently experience depression, Anxiety, and stress, which has a substantial negative impact on their quality of life and overall health-related satisfaction. This study aimed to identify psychiatric comorbidities in individuals with epilepsy, as assessed via the Depression, Anxiety, and Stress Scale, by comparing them with a healthy control group.
Methodology
This cross-sectional study was conducted in the XXXX, and patients were recruited from the Out-Patient Department of XXXX, from August 2022 to February 2024. The total number of participants was 388, including 194 Cases. 194 healthy controls were matched for age and sex, with participants under the age of 18 excluded. Psychiatric comorbidity was evaluated via the DASS-21 scale using Chi-square and one-way ANOVA.
Results
The study involved 194 patients and 194 healthy controls, with a mean age of 25.11 ± 10.28 years. Among the patients, 58.2% were female and 41.8% were male. A significant difference in depression levels was found between patients on monotherapy and polytherapy (p = 0.003). However, no significant differences were found in anxiety (p = 0.214) and stress (p = 0.139). There are no significant links between depression, anxiety, stress and antiepileptic drugs. Patients with epilepsy had significantly higher levels of depression, anxiety, and stress compared to healthy controls, with all p = 0.00.
Conclusion
The study highlights the elevated levels of depression, anxiety, and stress among patients with epilepsy. Clinicians and healthcare practitioners should adopt comprehensive and holistic assessment methods to address and mitigate these psychiatric comorbidities in epilepsy patients.
Sex Differences in the Modulation of Anxiety- and Depression-like Behaviors by Matrix Metalloproteinase-9 Expression Levels in Mice
Authors: Senserrich Júlia , Castro Elena , Florensa-Zanuy Eva , Díaz Álvaro , Pazos Ángel , Adell Albert , Tzinia Athina , Pilar-Cuéllar Fuencisla 
Published: January 2025

Abstract

Background: Major depressive disorder is one of the main causes of disability worldwide, but its etiopathology remains largely unknown, although several hypotheses have been proposed. Recent studies suggest a potential role for matrix metalloproteinase 9 (MMP-9) in depression, as it is overexpressed in the plasma of depressed patients and normalizes following chronic antidepressant treatment. This study aimed to characterize anxiety and depression-like behaviors in transgenic MMP-9 mice, as well as the expression of different neuroplasticity markers associated withdepression, in both sexes.
Methods: In this study, we characterized the behavioral phenotypes of both MMP-9 knockout and MMP-9-overexpressing male and female mice. Here, we used a battery of tests to assess anxiety (open field, light‒dark box, elevated plus maze, and novelty‒suppressedfeeding tests), depressive-like (tail suspension and social interaction tests), and cognitive (T-maze) behaviors.
Results: MMP-9 knockout female mice displayed increasedinnate anxiety (open field test), decreasedbehavioral despair (tail suspension test), and increased sociability (social interaction test). This increased sociability was also observed in male MMP-9 knockout mice. Compared with control mice, female MMP-9 knockout mice presented increased levels of different neuroplasticity markers in the hippocampus.
With respect to MMP-9-overexpressing mice, females presented decreasedinnate anxiety (elevated plus maze and light‒dark box). Male MMP-9-overexpressing mice presented greaterconflict-based anxiety (novelty-suppressed feeding test) and lower working memory (T-maze) than control mice did. These male mice presented a reduction in mTOR pathway activation and increased PSD95 hippocampal levels.
Conclusions: MMP-9 levels may have a sex-dependent impact on the anxious/depressive-like phenotype, as well as on neuroplasticity markers in the hippocampus. These findings reinforce the sex differences in the etiopathology of depression.