bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: hereditary role in non‐alcoholic fatty liver disease – authors' reply
Authors: Park Yewan , Sinn Dong H. , Gwak Geum‐Youn 
Published: December 2022

LINKED CONTENTThis article is linked to Park et al papers. To view these articles, visit https://doi.org/10.1111/apt.17257 and https://doi.org/10.1111/apt.17317
What ugly and beautiful photographs reveal about COVID‐19 lockdown experiences, everyday aesthetics and photography aesthetics
Authors: Vissers Nathalie , Wagemans Johan 
Published: December 2022

AbstractAgainst the backdrop of the COVID‐19 pandemic, which restricted our daily (visual) experiences, we asked people to take an ugly and beautiful photograph from within their homes. In total, 284 photographs (142 ugly and 142 beautiful) and accompanying statements were submitted and brought to light an intimate portrait of how participants were experiencing their (lockdown) home environment. Results revealed an aesthetic preference for (living) nature. Beauty and ugliness were also connected to good versus bad views, mess versus cosiness, unflattering versus flattering portraits and positive versus negative (COVID‐19) emotions. In terms of photography strategies, editing and colour were important for beautiful photographs, whereas a lack of effort and sharpness showed up relatively more in ugly photographs. A follow‐up study revealed that other viewers' (n = 86) aesthetic judgements of the photographs were largely in line with the original submissions, and confirmed several of the themes. Overall, our study provides a unique photographic window on our everyday aesthetic experiences at home during the COVID‐19 lockdown.
The demand for money and the real exchange rate misalignments in emerging European countries: A nonlinear approach
Authors: Uz Akdogan Idil 
Published: December 2022

AbstractThis paper investigates the extent to which domestic and foreign money balances in emerging European countries are influenced by foreign exchange considerations. A well‐specified and stable relationship between real money demand and the exchange rate can be perceived as an important part of a successful monetary policy. This study examines the long‐run determinants of real exchange rates (RERs) associated with the behavioral equilibrium exchange rate (BEER) approach and identifies currency misalignments in these countries. The misalignment is later used to test the nonlinear behavior of the demand for money. The results indicate that the RER misalignments have a significant impact on domestic money demand. When the currencies are overvalued, there is a reduction in domestic money demand, and when they are undervalued, there is an increase in domestic money demand. Furthermore, it can be concluded that overvaluation causes an increase in foreign money demand indicating a shift of preference from domestic to foreign currency.
Health‐related quality of life in food and venom induced anaphylaxis and role of influencing factors
Authors: Höfer Veronika , Martini Matteo , Dölle‐Bierke Sabine , Worm Margitta , Bilò Maria Beatrice 
Published: December 2022

AbstractThe impact on health‐related quality of life (HRQL) plays a key role for patients suffering from allergies and anaphylaxis. In this narrative review we review the HRQL in allergic patients suffering from food and venom allergy, both being the most frequent elicitors of severe allergic, potential life‐threatening reactions and provide an overview on the current knowledge and identified gaps.The data show that for food and venom allergy standardized assessment tools to measure HRQL are available and have been successfully applied. Our analysis shows that multiple factors can modulate HRQL in these patient groups. These include sociodemographic data like patients' age and sex, fear of accidental reactions but also external factors like the social environment and the appreciation of the seriousness of the condition by others. External factors may have a significant impact on HRQL and should be considered in patient‐related outcome assessments to avoid biased measurements possibly affecting the results. The assessment of the quality of life in the context of specific immunotherapy should consider lifestyle factors and ideally, the individual change in HRQL should be measured.Although there are many data indicating a negative impact on HRQL in food allergic children and their caregivers, limited data are existing from adults with food allergy and venom allergic patients from all age groups. Also, the use of standardized questionnaires should be extended to allow for a better comparability of results between studies. Therefore, translation to additional languages is necessary.Taken together, the eliciting allergen, the severity of the allergic disease but moreover multiple external factors impact the outcome in HRQL and should be considered in HRQL assessment.
Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation
Authors: Fang Ze‐Min , Zhang Shu‐Min , Luo Hanshen , Jiang Ding‐Sheng , Huo Bo , Zhong Xiaoxuan , Feng Xin , Cheng Wenlin , Chen Yue , Feng Gaoke , Wu Xingliang , Zhao Fang , Yi Xin 
Published: December 2022

AbstractPrevention of neointima formation is the key to improving long‐term outcomes after stenting or coronary artery bypass grafting. RNA N6‐methyladenosine (m6A) methylation has been reported to be involved in the development of various cardiovascular diseases, but whether it has a regulatory effect on neointima formation is unknown. Herein, we revealed that methyltransferase‐like 3 (METTL3), the major methyltransferase of m6A methylation, was downregulated during vascular smooth muscle cell (VSMC) proliferation and neointima formation. Knockdown of METTL3 facilitated, while overexpression of METTL3 suppressed the proliferation of human aortic smooth muscle cells (HASMCs) by arresting HASMCs at G2/M checkpoint and the phosphorylation of CDC2 (p‐CDC2) was inactivated by METTL3. On the other hand, the migration and synthetic phenotype of HASMCs were enhanced by METTL3 knockdown, but inhibited by METTL3 overexpression. The protein levels of matrix metalloproteinase 2 (MMP2), MMP7 and MMP9 were reduced, while the expression level of tissue inhibitor of metalloproteinase 3 was increased in HASMCs with METTL3 overexpression. Moreover, METTL3 promoted the autophagosome formation by upregulating the expression of ATG5 (autophagy‐related 5) and ATG7. Knockdown of either ATG5 or ATG7 largely reversed the regulatory effects of METTL3 overexpression on phenotypic switching of HASMCs, as evidenced by increased proliferation and migration, and predisposed to synthetic phenotype. These results indicate that METTL3 inhibits the phenotypic switching of VSMCs by positively regulating ATG5‐mediated and ATG7‐mediated autophagosome formation. Thus, enhancing the level of RNA m6A or the formation of autophagosomes is the promising strategy to delay neointima formation.
Comparison of visual and acoustic surveys for the detection and dynamic management of North Atlantic right whales (Eubalaena glacialis) in Canada
Authors: Ceballos Valentina , Taggart Christopher , Johnson Hansen 
Published: December 2022

AbstractThe goal of this study was to develop a simulation to quantitatively compare acoustic and visual surveys and use it to inform current and future North Atlantic right whale (Eubalaena glacialis) risk mitigation. We expanded upon an established whale movement model, incorporating realistic right whale cues for visual and acoustic detection within dynamic management zones in the Gulf of Saint Lawrence, Canada. Survey transits by acoustic (Slocum gliders) and visual (aircraft, vessels, and Remotely Piloted Aircraft Systems) platforms were simulated using representative platform movements and detection functions. We used a Monte Carlo approach to estimate the probability of detecting a cue, in each zone, as a function of survey platform, number of right whales, and survey transits. Acoustic gliders detected right whale presence in every scenario. Single transits of a management zone by visual surveys were only able to reliably (>0.5 probability) detect right whales when more than 20 whales were present. Twenty or more transits were required to reliably detect a single right whale. Our results serve as a tool to be used by decision‐makers to inform optimal right whale monitoring strategies that consider the relative strengths of the various platforms.
Towards effective management of an overabundant native bird: The noisy miner
Authors: Crates Ross , McDonald Paul G. , Melton Courtney B. , Maron Martine , Ingwersen Dean , Mowat Emily , Breckenridge Max , Murphy Liam , Heinsohn Robert 
Published: December 2022

AbstractAddressing threats to biodiversity from pest species is a global challenge. One such challenge is to mitigate the impact of an overabundant Australian songbird, the noisy minerManorina melanocephala,on woodland birds. The overabundance of noisy miners is listed as a key threatening process under federal biodiversity legislation, but current understanding of where and how noisy miner populations can be managed to yield conservation benefits is unclear. We evaluated the effectiveness of noisy miner removal across 12 treatment areas totaling 3913 ha and nine control areas totaling 1487 ha important for the critically endangered regent honeyeaterAnthochaera phrygia. Removal of noisy miners significantly reduced their densities in all but one of the treatment areas. In 10 of the 12 treatment areas, noisy miner densities remained below an impact threshold of 0.65–0.83 birds ha−1for at least 3 to more than 12 months. The percentage of suitable noisy miner habitat in the surrounding landscape was not a strong predictor of noisy miner management success. Regent honeyeaters occupied six treatment areas, nesting successfully in four. The abundance of other songbirds increased post‐miner removal in seven areas, decreased in three, and was mixed in two. Data from the control areas showed some variation in songbird numbers was independent of noisy miner management. We conclude that noisy miners can be managed in areas of high conservation value for a minimum cost of AUD $10 ha−1. Larger treatment areas may be more important than the broader landscape context in maintaining long‐term noisy miner suppression. Standardized, long‐term monitoring is crucial to identify not only the drivers of pest species recolonization but also locations where threats from pests on endangered species can be addressed effectively while minimizing animal welfare and financial costs.
First‐in‐human study of JNJ‐63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia
Authors: Boyiadzis Michael , Desai Pinkal , Daskalakis Nikki , Donnellan William , Ferrante Lucille , Goldberg Jenna D. , Grunwald Michael R. , Guttke Christina , Li Xiang , Perez‐Simon Jose Antonio , Salamero Olga , Tucker Trevor , Xu Xiaoying , Yang Jay , Pemmaraju Naveen , Alonso‐Dominguez Juan Manuel 
Published: December 2022

AbstractThis study aimed to identify a recommended phase II dose and evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and preliminary clinical activity of JNJ‐63709178, a CD123/CD3 dual‐targeting antibody, in patients with relapsed or refractory acute myeloid leukemia. Intravenous (i.v.) and subcutaneous (s.c.) administration of JNJ‐63709178 were evaluated. The i.v. infusions were administered once every 2 weeks (cohorts 1–5 [n = 17]) or twice weekly (cohorts 6–11 [n = 36]). A twice‐weekly s.c. dosing regimen with step‐up dosing was also studied (s.c. cohorts 1–2 [n = 9]). Treatment‐emergent adverse events (TEAEs) greater than or equal to grade 3 were observed in 11 (65%) patients in cohorts 1–5 and 33 (92%) patients in cohorts 6–11. At the highest i.v. dose (4.8 μg/kg), 5 (71%) patients discontinued treatment due to TEAEs. For s.c. administration (n = 9), eight (89%) patients experienced TEAEs greater than or equal to grade 3 and injection site reactions (≤ grade 3) emerged in all patients. At 4.8 μg/kg (i.v. and s.c.), the mean maximum serum concentrations were 30.3 and 3.59 ng/ml, respectively. Increases in multiple cytokines were observed following i.v. and s.c. administrations, and step‐up dosing strategies did not mitigate cytokine production or improve the safety profile and led to limited duration of treatment. Minimal clinical activity was observed across all cohorts. The i.v. and s.c. dosing of JNJ‐63709178 was associated with suboptimal drug exposure, unfavorable safety profiles, limited clinical activity, and inability to identify a recommended phase II dose.
Association of long‐term hyperglycaemia and insulin resistance with brain atrophy and cognitive decline: A longitudinal cohort study
Authors: Yu Ji Hee , Kim Regina E. Y. , Park So Young , Lee Da Young , Cho Hyun Joo , Kim Nam Hoon , Yoo Hye Jin , Seo Ji A , Kim Sin Gon , Choi Kyung Mook , Baik Sei Hyun , Shin Chol , Kim Nan Hee 
Published: December 2022

AbstractAimTo investigate the longitudinal changes in brain volume and cognitive function associated with diabetes at midlife, and to examine whether long‐term hyperglycaemia, insulin resistance or secretory function is associated with brain atrophy and cognitive decline.Materials and MethodsWe used data from 2377 participants with both baseline and 4‐year follow‐up brain magnetic resonance images and neuropsychological measures from the Ansan cohort of the Korean Genome Epidemiology Study. Time‐weighted mean glycaemic values were calculated using all measurements over an average duration of 10.6 years from cohort initiation to baseline visits.ResultsType 2 diabetes was associated with greater white matter volume reduction (adjusted volume difference = −1.96 ml, 95% CI: −3.73, −0.18) and executive function decline (adjusted Z score difference = −0.14, 95% CI: −0.23, −0.05) during the follow‐up period of 4.2 years. Decline of verbal and visual memory or verbal fluency was not associated with diabetes. Greater executive function decline was associated with higher time‐weighted mean HbA1c level over the preceding 10.6 years (P < .001), but not with insulin resistance markers in the diabetes group. Participants with diabetes, whose time‐weighted average HbA1c level was maintained above 6.5% over the previous decade, showed greater decline in executive function and global cognition than the normal glucose group.ConclusionsLong‐term hyperglycaemia was a major independent factor associated with rapid cognitive decline in middle‐aged adults with diabetes. Maintaining ideal glucose levels in diabetes at midlife might prevent later rapid cognitive decline.
From boom to gloom: Brazilian labour productivity in manufacturing relative to the United States, 1912–2019
Authors: Lara Cecilia , Prado Svante 
Published: December 2022

AbstractWhereas manufacturing seems to hold the key to modern economic growth, the role of manufacturing in economy‐wide convergence across countries is debatable. One strand of scholarship argues that productivity levels in manufacturing tend to remain stable across countries, and that economy‐wide convergence takes place through structural transformations. Another strand maintains that productivity levels of less‐developed countries tend to approach those of developed countries unconditionally, and that deindustrialization thwarts economy‐wide convergence. We examine productivity in Brazilian manufacturing relative to the United States, 1912–2019. The result shows dramatic swings in the Brazilian/US productivity ratio, increasing in the decades following the Second World War, peaking in the late 1970s at impressively high levels, and declining precipitously thereafter. This sluggish performance of Brazilian manufacturing since the peak in the late 1970s has probably hindered income convergence with richer countries.
Efficacy and safety of calcium channel blockers in preventing cardiac siderosis in thalassemia patients: An updated meta‐analysis with trial sequential analysis
Authors: Soliman Youssef , Abdelaziz Ahmed , Mouffokes Adel , Amer Basma E. , Goudy Yomna Mohamed , Abdelwahab Omar Ahmed , Badawy Marwa M. , Diab Rehab Adel , Elsharkawy Asmaa 
Published: December 2022

AbstractObjectivesIron overload in patients with thalassemia represents a serious complication by affecting numerous organ systems. This meta‐analysis aims to establish an evidence regarding the effect of amlodipine on cardiac iron overload in thalassemia patients.MethodsWe searched PubMed, Scopus, Web of Science, Cochrane Central, and EMBASE for all relevant randomized controlled trials (RCTs). The primary outcomes were cardiac T2* and myocardial iron concentration (MIC). Secondary outcomes were liver iron concentration (LIC), risk of Gastrointestinal (G.I.) upset and risk of lower limb edema. We used Hedges' g to pool continuous outcomes, while odds ratio was used for dichotomous outcomes.ResultsSeven RCTs were eligible for this systematic review and meta‐analysis, comprising of 233 patients included in the analysis. Amlodipine had a statistically significant lower MIC (Hedges' g = −0.82, 95% confidence interval [CI] [−1.40, −0.24], p < .001) and higher cardiac T2* (Hedges' g = 0.36, 95% CI [0.10, 0.62], p = .03). Amlodipine was comparable to standard chelation therapy in terms of the risk of lower limb edema and GI upset.ConclusionOur meta‐analysis found that amlodipine significantly increases cardiac T2* and decreases MIC, hence decreasing the incidence of cardiomyopathy‐related iron overload in thalassemia patients.
Distribution of soil bacteria involved in C cycling across extensive environmental and pedogenic gradients
Authors: Xue Peipei , Minasny Budiman , McBratney Alex , Pino Vanessa , Fajardo Mario , Luo Yu 
Published: December 2022

AbstractMicroorganisms play pivotal roles in soil processes. Metabolically related microorganisms constitute functional groups, and diverse microbial functional groups control nutrient cycling in soils. This study explored environmental (i.e., rainfall, temperature) and soil factors driving the distribution of bacterial functional groups involved in soil carbon (C) cycling in paired natural and agricultural ecosystems. Soil samples were collected at a regional scale covering gradients of temperature and rainfall across two orthogonal transects (~1000 km) in New South Wales, Australia. Putative functions of bacteria were linked to two soil C fractions: particulate organic carbon (POC) and mineral‐associated organic carbon (MAOC). We found: (i) temperature and rainfall were important drivers of bacterial functional groups, while soil properties, such as pH, soil C and nitrogen (N), also presented significant contributions; (ii) community structure of bacteria involved in C cycling was mainly related to POC content but not to MAOC; (iii) paired sampling showed that agricultural practices had significant impacts on the composition and responses of soil bacterial functional groups. This study demonstrated the environmental regulation (e.g., temperature and rainfall) of soil microbial functional groups at large scales, which was altered by agricultural practices.Highlights
Soil bacteria involved in C cycling were investigated across two ~1000 km transects.
Temperature and rainfall were important drivers of bacterial functional groups at large scale.
Paired sampling showed that agriculture led to a significant shift in bacterial functional groups.
Community structure of bacterial functional groups were correlated with soil POC but not MAOC.
RETRACTED: Segmentation and classification of lymphoblastic leukaemia using quantum neural network
Authors: Amin Javeria , Anjum Muhammad Almas , Krivic Senka , Sharif Muhammad Irfan 
Published: December 2022

AbstractIn lymphoblastic leukaemia (ALL), the bone marrow naturally produces immature cells. Each year ALL is diagnosed with over 6500 instances, and the trend is still going upward. Technological advancements in AI and big data analytics help doctors and radiologists make accurate and efficient clinical decisions. The proposed method consists of two core steps: segmentation and classification based on the quantum convolutional networks. A three‐dimensional U‐network is proposed having 70 layers that are trained on the optimal hyperparameters, which provides 0.98 dice scores. The four‐qubit quantum transfer learning model is proposed for classifying different types of blood cells. The accuracies achieved are 0.99 on blast cells, 0.99 on Basophils, 0.98 on Eosinophils, 0.97 on Neutrophils, 0.99 on Lymphocytes, and 0.96 on Monocytes. The proposed classification model provides 0.99 average accuracy.
Parenthood during the COVID‐19 pandemic: Post‐traumatic growth amongst university students
Authors: Harwood‐Gross Anna , Bergman Yoav S. , Pat‐Horenczyk Ruth , Schiff Miriam , Benbenishty Rami 
Published: December 2022

AbstractThis study sought to investigate a positive dimension of coping with the COVID‐19 pandemic, that of post‐traumatic growth (PTG). This study investigated coping difficulties and PTG amongst parent and nonparent students in Israeli Universities. A total of 4022 parents (3648 Jews and 374 Palestinian‐Arab Citizens [PACs]) and 14,651 nonparents (12,010 Jews and 2641 PACs) completed measures of coping, social support and PTG. Parents demonstrated significantly higher levels of coping and PTG. Amongst parents, fathers coped slightly better than mothers; however, while Jewish mothers demonstrated greater PTG than Jewish fathers, PAC fathers had significantly greater PTG than both PAC mothers and Jewish parents. These findings, while specific to COVID‐19, indicate that PTG should be studied in greater depth in different ethnic and minority groups in order to develop enhanced understanding and facilitate promotion of post‐traumatic growth, in addition to the prevention of COVID‐19‐related distress.
Geographies of empire: Infrastructure and agricultural intensification in Haiti
Authors: Moore Sophie Sapp , Koski‐Karell Victoria 
Published: December 2022

AbstractThe implementation of US‐backed agricultural initiatives under what became known as the Green Revolution (1945–1970) reshaped populations, ecologies, and landscapes worldwide. While most investigations into the implications of this era focus on the development of intensive farming in places such as Mexico, India, and the Philippines, few offer critical analysis of its Caribbean manifestations. This paper examines the role of the Green Revolution in the production of environmental injustice in Haiti. Historically, we situate Green Revolution technopolitics in a broader trajectory of US‐led imperial and neoliberal interventions that spans from the Occupation of Haiti (1915–1934) to the 21st century. We draw from our long‐term ethnographic research to show how Green Revolution transformations impact agrarian life in Haiti's lower Artibonite Valley and Central Plateau today. Integral to the Occupation were efforts to (re)establish production of export commodities. We demonstrate how such attempts, regardless of outcome, generated indelible material, social, and ecological entanglements that served to intensify empire. In 1949, the US and Haitian governments established an agency tasked with extending Occupation‐era irrigation infrastructure throughout the Artibonite Valley. After these efforts stalled, 1970s interventionists sought different inroads for increasing agricultural production, particularly of rice. Their initiatives paved the way for post‐2010 ventures that perpetuate many of the same consequences, including hunger, economic insecurity, and environmental degradation. We show how the history of imperial intervention in Haiti created the conditions for the ongoing production of environmental injustice through agrarian reform. Ultimately, we argue that the Green Revolution transformed Haiti's agrarian geographies in ways that intensified environmental harms and advanced a project of US empire that continues to shape Haiti today. We examine the contemporary implications of this century of transformation for farmers, who carry on a legacy of agrarian justice that has contested the project of the Green Revolution since its inception.