bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deafness induces complete crossmodal plasticity in a belt region of dorsal auditory cortex
Authors: Merrikhi Yaser , Mirzaei Ali , Kok Melanie A. , Meredith M. Alex , Lomber Stephen G. 
Published: July 2023

AbstractMany neural areas, where patterned activity is lost following deafness, have the capacity to become activated by the remaining sensory systems. This crossmodal plasticity can be measured at perceptual/behavioural as well as physiological levels. The dorsal zone (DZ) of auditory cortex of deaf cats is involved in supranormal visual motion detection, but its physiological level of crossmodal reorganisation is not well understood. The present study of early‐deaf DZ (and hearing controls) used multiple single‐channel recording methods to examine neuronal responses to visual, auditory, somatosensory and combined stimulation. In early‐deaf DZ, no auditory activation was observed, but 100% of the neurons were responsive to visual cues of which 21% were also influenced by somatosensory stimulation. Visual and somatosensory responses were not anatomically organised as they are in hearing cats, and fewer multisensory neurons were present in the deaf condition. These crossmodal physiological results closely correspond with and support the perceptual/behavioural enhancements that occur following hearing loss.
Functional tics: Expanding the phenotypes of functional movement disorders?
Authors: Cavanna Andrea E. , Purpura Giulia , Riva Anna , Nacinovich Renata , Seri Stefano 
Published: July 2023

AbstractBackground and purposeUntil the outbreak reported during the COVID‐19 pandemic, functional tics were considered to be a relatively rare clinical phenotype, as opposed to other functional movement disorders such as functional tremor and dystonia. To better characterize this phenotype, we compared the demographic and clinical characteristics of patients who developed functional tics during the pandemic and those of patients with other functional movement disorders.MethodsData from 110 patients were collected at the same neuropsychiatry centre: 66 consecutive patients who developed functional tics without other functional motor symptoms or neurodevelopmental tics and 44 patients with a mix of functional dystonia, tremor, gait, and myoclonus.ResultsBoth groups were characterized by female sex preponderance (70%–80%) and (sub)acute onset of functional symptoms (~80%). However, patients with functional tics had a significantly earlier age at onset of functional symptoms (21 vs. 39 years). Exposure to relevant social media content was reported by almost half of the patients with functional tics, but by none of the patients with other functional movement disorders. Comorbidity profiles were similar, with relatively high rates of anxiety/affective symptoms and other functional neurological symptoms (nonepileptic attacks).ConclusionsPatients who developed functional tics during the pandemic represent a phenotypic variant of the wider group of patients with functional movement disorders, associated with younger age at onset and influenced by pandemic‐related factors, including increased exposure to specific social media content. Diagnostic protocols and treatment interventions should be tailored to address the specific features of this newly defined phenotype.
A new record of an invasive aquatic fern from Türkiye: Salvinia molesta
Authors: Şenol S. G. , Bozyel D. , Pelit N. B. 
Published: July 2023

AbstractSalvinia molesta D.S. Mitch, which is on the list of harmful invasive species in many countries, is reported from Muğla–Köyceğiz as a new invasive species record for the flora of Türkiye. This species was found by chance on 11 March 2017, during the field work of the date palm project (TUBİTAK 116Z288) carried out by the authors. In the article a description of the species and detailed photographs and information on its distribution are given.
List of aphids (Hemiptera: Aphidoidea) intercepted at South Korean plant quarantine
Authors: Suh Soo‐Jung 
Published: July 2023

AbstractA list of 75 species of aphids which have been intercepted on plants imported into South Korea over the past 27 years (from 1996 to 2022) including information on the number of interceptions, host plants and their distribution is provided. Data on intercepted species were analysed to determine potential invasive species of aphids that could threaten South Korean agroecosystems.
Evidence of hybridization between genetically distinct Baltic cod stocks during peak population abundance(s)
Authors: Helmerson Cecilia , Weist Peggy , Brieuc Marine Servane Ono , Maurstad Marius F. , Schade Franziska Maria , Dierking Jan , Petereit Christoph , Knutsen Halvor , Metcalfe Julian , Righton David , André Carl , Krumme Uwe , Jentoft Sissel , Hanel Reinhold 
Published: July 2023

AbstractRange expansions can lead to increased contact of divergent populations, thus increasing the potential of hybridization events. Whether viable hybrids are produced will most likely depend on the level of genomic divergence and associated genomic incompatibilities between the different entities as well as environmental conditions. By taking advantage of historical Baltic cod (Gadus morhua) otolith samples combined with genotyping and whole genome sequencing, we here investigate the genetic impact of the increased spawning stock biomass of the eastern Baltic cod stock in the mid 1980s. The eastern Baltic cod is genetically highly differentiated from the adjacent western Baltic cod and locally adapted to the brackish environmental conditions in the deeper Eastern basins of the Baltic Sea unsuitable for its marine counterparts. Our genotyping results show an increased proportion of eastern Baltic cod in western Baltic areas (Mecklenburg Bay and Arkona Basin)—indicative of a range expansion westwards—during the peak population abundance in the 1980s. Additionally, we detect high frequencies of potential hybrids (including F1, F2 and backcrosses), verified by whole genome sequencing data for a subset of individuals. Analysis of mitochondrial genomes further indicates directional gene flow from eastern Baltic cod males to western Baltic cod females. Our findings unravel that increased overlap in distribution can promote hybridization between highly divergent populations and that the hybrids can be viable and survive under specific and favourable environmental conditions. However, the observed hybridization had seemingly no long‐lasting impact on the continuous separation and genetic differentiation between the unique Baltic cod stocks.
Geographies of big water infrastructure: Contemporary insights and future research opportunities
Authors: Birkenholtz Trevor 
Published: July 2023

AbstractLargescale “big” water infrastructure is once again at the forefront of the global developmentalist agenda and is receiving attendant scholarly attention. Given this parallel growth, now is time to take stock of current scholarly contributions and explore opportunities for future research. In this paper, I review recent developments and insights gained from research on big water infrastructure, and water infrastructure studies, generally, to highlight six key threads of current scholarship. These include the production of big water infrastructure as: (1) a temporal process embedded in colonialism and ecological modernization; (2) infused with infrastructural knowledges, practices and subjectivities; (3) a spatial‐geopolitical process; (4) subject to infrastructural and environmental material characteristics and capacities; (5) producing uneven development and enabling accumulation by dispossession; and (6) a contested process of differentiated socio‐material resistance. In reviewing this literature, I argue that these six research strands form key analytic considerations that could be employed by others studying the nexus between water development, political ecological change, and infrastructure. Before concluding, in the final section of the paper I present additional and ongoing future research directions including big water infrastructure as it intersects with socially differentiated human intimacy and embodiment, indigenous and racialized forms of dispossession, and financialization.
RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming
Authors: Yan Dali , Xie Yongsong , Huang Liyuan , Zhang Yi , Gu Runhuan , Xie Huaibing , Huang Xing , Luo Hao 
Published: July 2023

AbstractRecently, epigenetics showed essential roles in tumour microenvironment (TME) and immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) modification in TME remains unknown. According to 13 m5C regulators, we evaluated 412 BLCA patients from The Cancer Genome Atlas (TCGA) database. The m5C score was constructed by unsupervised clustering analysis and principal component analysis (PCA) algorithms. Gene set variation analysis (GSVA), ESTIMATE algorithm, and immunohistochemical (IHC) staining were performed. Macrophage chemotaxis assay was used to assess the M2 macrophages. Among the 412 patients, the frequency of mutation was 13%. m5C regulators was expressed significantly in BLCA tissue compared with normal tissue. Then, two m5C methylation modification patterns were identified with dissimilar TME cell infiltration patterns. The C1 alteration pattern in the m5C cluster was connected with better survival. In addition, we found that NSUN6 was highly correlated with recruitment of macrophages via bioinformatics and IHC. Further experiment validated that NSUN6 promoted HDAC10 expression by mediating m5C methylation, inhibited the transcription of macrophage‐associated chemokines and thus inhibited the recruitment of M2 macrophages. The m5C score constructed by m5C modification pattern showed that high m5C score group had a better prognosis. This study uncovered the significant roles of m5C modifications in modulating the TME and indicated that NSUN6 could inhibit the recruitment of M2 macrophages via m5C methylation, which provided novel insight into epigenetic regulation of TME and clinical suggestions for immunotherapeutic strategies.
Evaluation of pathogen distribution and antimicrobial resistance in breast plastic surgery infection
Authors: Su Xueshang , Hu Jintian , Jiang Fengli , Wu Yuanyuan , He Jingjing , Jia Ximeng , Zhan Sien 
Published: July 2023

AbstractBackgroundThe demand for mammaplasty has increased in recent years, and infection remains one of the common and serious post‐operative complications. In this study, we analyzed the pathogen distribution and antibiotic susceptibility of breast plastic surgery infections, and compared the differences in pathogenic species between surgical procedures.MethodsThe number of each species was counted in the microbial samples of breast plastic surgery infections in Plastic Surgery Hospital of Chinese Academy of Medical Sciences from January 2011 to December 2021. The in vitro antibiotic sensitivity testing data were analyzed using WHONET 5.6 software. The surgical techniques, the period of infection, and other details were gathered in accordance with the clinical data.ResultsThere were a total of 42 cases included, and 43 different types of pathogenic bacteria, mostly gram‐positive bacteria, were found. CoNS (13/43) and Staphylococcus aureus (22/43) made up the majority. The most prevalent of the five Gram‐negative bacteria was Pseudomonas aeruginosa. Results of drug sensitivity tests indicate that S. aureus is highly sensitive to vancomycin, cotrimoxazole, and linezolid, whereas CoNS is highly sensitive to vancomycin, linezolid, and chloramphenicol. Both of these bacteria show high resistance to erythromycin and penicillin. Breast augmentation, breast reconstruction, and breast reduction surgery were the most frequently associated breast surgery procedures in this study with infections, with the highest number of infections occurring following breast augmentation with fat grafting, breast reduction surgery, and breast reconstruction with autologous tissue. Various breast plastic surgery procedures have different common pathogens of infection, but the most prevalent are CoNS and S. aureus. Additionally, the majority of the infections in this study were in the early stages.ConclusionsGram‐positive bacteria were the predominant cause of breast plastic surgery infections, and the types of infection strains, the period of infection onset, and the antibiotic susceptibility of prevalent strains varied between breast plastic procedures.
Exploring continuity of care for women with prenatal diagnosis of congenital anomaly: A mixed method study
Authors: Psaila Kim M. , Schmied Virginia , Heath Susan 
Published: July 2023

AbstractAimsTo map the pathway and service provision for pregnant women whose newborns require admission into the surgical neonatal intensive care unit at or soon after birth, and to examine the nature of continuity of care (COC) provided and the facilitators and barriers to woman‐ and family‐centred care from the perspective of women/parents and health professionals.BackgroundLimited research exists on current service and care pathways for families whose babies are diagnosed with congenital abnormality requiring surgery.DesignA mixed method sequential design adhering to EQUATOR guidelines for Good Reporting of a Mixed Methods Study.MethodsData collection methods included: (1) a workshop with health professionals (n = 15), (2) retrospective maternal record review (n = 20), prospective maternal record review (17), (3) interviews with pregnant women given a prenatal diagnosis of congenital anomaly (n = 17) and (4) interviews with key health professionals (n = 7).Results/FindingsParticipants perceived care delivered by state‐based services as problematic prior to admission into the high‐risk midwifery COC model. Once admitted to the high‐risk maternity team women described care ‘like a breath of fresh air’ with a ‘contrast in support’, where they felt supported in their decisions.ConclusionThis study highlights provision of COC, in particular relational continuity between health providers and women as essential to achieve optimal outcomes.Relevance to Clinical PracticeProvision of individualised COC offers an opportunity for perinatal services to reduce the negative consequences of pregnancy‐related stress associated with diagnosis of foetal anomaly.Patient or Public ContributionNo patient or public was involved in the design, analysis, preparation or writing of this review.
The effect of the Litcubanine A on the treatment of murine experimental periodontitis by inhibiting monocyte–macrophage chemotaxis and osteoclast differentiation
Authors: Chen Yingyi , Liu Yitong , Xia Huan , Xia Guiyang , Xu Junji , Lin Sheng , Guo Lijia , Liu Yi 
Published: July 2023

AbstractBackgroundPeriodontal disease is an inflammatory disease of periodontal tissues that is closely connected with systemic diseases. During periodontitis, the inappropriate recruitment and activation of monocytes–macrophages causes an increase in osteoclast activity and disrupts bone homeostasis. Therefore, it is a promising therapeutic strategy to treat periodontitis by regulating the functions of monocytes–macrophages. Litcubanine A (LA) is an isoquinoline alkaloid extracted from the traditional Chinese medicine Litsea cubeba, which was proven to have reproducible anti‐inflammatory effects, but its regulatory role on bone homeostasis in periodontitis is still not clear.MethodsIn this study, zebrafish experiments and a mouse ligature‐induced periodontitis model were performed, and histological analysis was used to investigate the effect of LA on macrophage chemotaxis under the inflammatory environment. Real‐time PCR was used to detect the regulatory effect of LA (100 nM ~ 100 μM) on the chemotaxis function of macrophages induced by LPS. Apoptosis assay and flow cytometry were used to elucidate the influence of LA on macrophage apoptosis and proliferation. To further clarify the regulatory role of LA on macrophage osteoclast differentiation, real‐time PCR, histological analysis, western blot, and micro‐computed tomography (micro‐CT) were performed in vivo and in vitro to verify the impact of LA on bone homeostasis.ResultsCompared with the control group, the chemotaxis function of macrophage was significantly attenuated by LA in vivo. LA could significantly inhibit the expression of genes encoding the chemokine receptors Ccr1 and Cxcr4, and its ligand chemokine Cxcl12 in macrophages, and suppresses the differentiation of osteoclastic precursors to osteoclasts through the MAPK signaling pathway. There were significantly lower osteoclast differentiation and bone loss in the LA group compared with the control in the ligature‐induced periodontitis model.ConclusionLA is a promising candidate for the treatment of periodontitis through its reproducible functions of inhibiting monocyte–macrophage chemotaxis and osteoclast differentiation.
Variation in autotrophic and heterotrophic sponge abundance in a shallow water seagrass system
Authors: Bachtiar Ramadian , Madduppa Hawis H. , Bell James J. 
Published: July 2023

AbstractSponges are well known to feed heterotrophically through suspension feeding, but their relationships with photosynthetic symbionts mean they also have the potential to utilise or release photosynthetically derived carbon. Here, we determined the nutritional mode of sponges that occurred seagrass meadows at two sites in the Wakatobi National Park (Hoga‐1 and 2), Indonesia from the near‐reef flat (d = 1.9 m), middle‐shore (d = 1.2 m) and high‐shore (d = 0.5 m) zones to assess the role they might play in nutrient fluxes. We measured photosynthetic pigment concentrations and in situ net primary production to dark respiration (P:R) ratios of eight sponge species representing 75%–100% of the total sponge assemblage biomass at the two sites. We found that six of eight sponge species were autotrophic, based on their instantaneous P:R ratios and estimated daily oxygen production/consumption. The proportion of autotrophic sponge biomass in the high and middle shore of the seagrass meadows ranged between 40% and 70%, and accounted for 98% and 81% of the biomass in the near‐flat zones. Our findings that many seagrass sponges are autotrophic challenges the general view that sponges are consumers of organic carbon from the water column.
Building the competency of health professionals in the Kyrgyz Republic for the Baby‐Friendly Hospital Initiative
Authors: Klein Alyssa , Block Charlotte , Mansimov Adil , Okenov Samat , Alvey Jeniece , Abazbekova Nazgul , Mukuria‐Ashe Altrena 
Published: July 2023

AbstractHealth professional competency building is one of nine national responsibilities (to achieve universal coverage and sustainability) described in the 2018 World Health Organization/UNICEF implementation guidance for the Baby‐Friendly Hospital Initiative (BFHI). Skilled breastfeeding support as a standard of newborn care is critical to the establishment of lactation and exclusive breastfeeding. This qualitative case study describes the Kyrgyz Republic's experience with health professional competency building related to breastfeeding counselling and support. We interviewed 38 key informants and reviewed national policies and international guidelines related to BFHI. The study found that although the country has a new policy reflecting BFHI global standards and guidance, the policy has not been disseminated nationally. Additionally, the policy lacks guidance on competency monitoring and verification and does not mention preservice training, even though preservice training on breastfeeding support exists. To achieve universal coverage for health professional competencies, the Kyrgyz Republic uses preservice, in‐service and refresher training. However, the main limitations to aligning with the new guidance are a lack of preservice BFHI‐ and breastfeeding‐specific curricula, experienced trainers and sufficient time and funding to dedicate to practical skill development. Conducted during the COVID‐19 pandemic, this study confirmed disruptions to BFHI training and service delivery but also documents the Kyrgyz Republic's resilient strides to mitigate impacts on breastfeeding support through facility‐level individual champions and adjustments to training such as going online. Opportunities exist for strengthening the competencies of service providers through strengthened preservice training, comprehensive and consistent in‐service training, solutions for overworked service providers and clear and sufficiently funded monitoring guidance.
Moving metals: How microbes deliver metal cofactors to metalloproteins
Authors: Kunkle Dillon E. , Skaar Eric P. 
Published: July 2023

AbstractFirst row d‐block metal ions serve as vital cofactors for numerous essential enzymes and are therefore required nutrients for all forms of life. Despite this requirement, excess free transition metals are toxic. Free metal ions participate in the production of noxious reactive oxygen species and mis‐metalate metalloproteins, rendering enzymes catalytically inactive. Thus, bacteria require systems to ensure metalloproteins are properly loaded with cognate metal ions to maintain protein function, while avoiding metal‐mediated cellular toxicity. In this perspective we summarize the current mechanistic understanding of bacterial metallocenter maturation with specific emphasis on metallochaperones; a group of specialized proteins that both shield metal ions from inadvertent reactions and distribute them to cognate target metalloproteins. We highlight several recent advances in the field that have implicated new classes of proteins in the distribution of metal ions within bacterial proteins, while speculating on the future of the field of bacterial metallobiology.
Dietary prevention strategies for childhood asthma
Authors: Brustad Nicklas , Bønnelykke Klaus , Chawes Bo 
Published: July 2023

AbstractAsthma is the most common chronic disease in childhood and a rise in prevalence has been observed concomitantly with changing dietary habits in the Western world. This change has favored a more Westernized diet characterized by high intake of processed food and fat in contrast to a Mediterranean diet high in fruit, vegetable and fish intake. This has resulted in a decreased intake of several antioxidants and micronutrients including n‐3 long‐chained polyunsaturated fatty acids and vitamin D that are speculated to have anti‐inflammatory effects and hold immunoregulatory properties. Several observational studies have investigated associations between dietary intake and wheeze and asthma but only few large well‐conducted randomized controlled trials (RCTs) have been performed investigating the primary preventive effect of micronutrient supplementations. Currently, the recommendations from the Global Initiative for Asthma (GINA) for primary prevention of asthma in children do not include maternal dietary changes or supplementations during pregnancy, although the most recent report mentions both specific dietary patterns and micronutrients as potential protective supplementation regimes. This review will present the current literature and future research needs focusing on primary and secondary prevention of both early and late childhood asthma from dietary intake during pregnancy and early childhood to highlight potential preventive effects of specific dietary patterns and micronutrient supplements, which may facilitate the planning of future clinical trials in search of a preemptive strategy.