bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and validity of a virtual reality-based measurement of simple reaction time: a cross-sectional study
Authors: Chen Ying-Chun , Liang Huey-Wen 
Published: May 2023

Abstract

BackgroundReaction time (RT) is an important dependent variable to assess components of cognitive function. Thus, it has been a valuable parameter for research and clinical evaluation. A head-mounted display for virtual reality (HMD-VR) provides a standardized external visual condition and could be a promising tool for measuring RT. The purpose of this study is to establish the feasibility, reliability, and validity of HMD-VR-based software in evaluating simple RT (SRT).MethodsThirty healthy participants volunteered for the study. A SRT test was created by VIVE ProEye (HTC, Inc.). The participants responded with a keyboard when a square target was used in random intervals for 100 trials. To determine the optimal test repetition, the difference between the SRTS calculated with different trial numbers was analyzed. The one-week reliability of the median SRT was evaluated with the intraclass correlation coefficient (ICC). Finally, the convergent validity was tested by computing the correlation coefficient with a personal computer-based (PC-based) software, RehaComÒ(HASOMED, Inc.) with a similar task design.ResultsThe median SRTs of the virtual reality-based (VR-based) and computer-based systems were 326.0 and 319.5 ms, respectively. Significantly longer RT obtained by the VR-based method was observed in the last 25-trial block for the non-dominant hand and bilateral hands according to Friedman’s test. The ICC was 0.71 (p<0.001), indicating good test-retest reliability. There was a high correlation (r=0.85~0.89) and good agreement between the VR-based and PC-based tests, with the VR-based SRT being 9-10 ms longer than the PC-based SRT according to Bland–Altman plots.ConclusionsOur results supported the good reliability and high convergent validity of this HMD-VR-based RT testing. A test length of 50 trials was suggested to avoid possible decremental performance while maintaining good reliability. The program can be applied in future studies when spatial-specific RT is the main interest to provide a standardized external environment.
Supporting the “Hallway Residents”: A Qualitative Descriptive Study of Staff Perspectives on Implementing the Namaste Care Intervention in Long-Term Care
Authors: Li Donny , Yous Marie-Lee , Hunter Paulette , Coker Esther , Just Danielle , Haas Vanina Dal-Bello , McAiney Carrie , Wickson-Griffiths Abigail , Kaasalainen Sharon 
Published: May 2023

Abstract

Background Residential long-term care settings are becoming home to an increasing number of people living with advanced or late-stage dementia. Residents living with advanced dementia represent some of society’s most vulnerable and socially excluded population and are thus at an increased risk of social isolation. A multisensory intervention tailored to this population,Namaste Care, has been developed to improve quality of life for residents living with advanced dementia in long-term care homes. To date, limited research has explored the perspectives of staff in implementing the Namaste Care program with an emphasis on social inclusion of residents in Canadian LTC homes. This study aimed to explore the perspectives of LTC staff on the ability of Namaste Care to support the social inclusion of residents living with advanced dementia and implementation facilitators and barriers. Methods Using a qualitative descriptive design, semi-structured interviews (n = 12) and focus groups (n = 6) were conducted in two long-term care homes in Southern Ontario, Canada, over a 6-month period. Convenience sampling was used to recruit long-term care home staff from the two participating sites. Thematic analysis was used to analyze data. Results LTC staff (n = 46) emphasized the program’s ability to recognize the unique needs of residents with advanced dementia, and also stated its potential to facilitate meaningful connections between families and residents, as well as foster care partnerships between staff and families. Findings indicated staff also perceived numerous facilitators and barriers to Namaste Care. In particular, providing staff with dedicated time for Namaste Care and implementing volunteer and family participation in the program were seen as facilitators, whereas the initial perception of the need for extra staff to deliver Namaste Care and identifying times in the day where Namaste Care was feasible for residents, families, and staff, were seen as barriers. Conclusions LTC staff recognized the need for formalized programs like Namaste Care to address the biopsychosocial needs of residents with advanced dementia and offer positive care partnership opportunities between staff and family members. Although staffing constraints remain the largest barrier to effective implementation, staff valued the program and made suggestions to build LTC home capacity for Namaste Care.
Analysis of plasma exosomal miRNAs in papillary thyroid carcinoma with or without lymph node metastasis
Authors: Cao Xianjiao , He Qingqing 
Published: May 2023

Abstract
Objective: Lymph node metastasis (LNM) is one of the difficulties in the treatment of papillary thyroid carcinoma (PTC). To improve the early detection of PTC LNM and search for novel biomarkers, we carried out plasma-derived exosomal microRNAs studies to identify candidate differentially expressed (DE) exosome-derived miRNAs (Ex- miRNAs) as diagnostic biomarkers in several plasma samples from LNM subjects and patients without LNM.
Methods: From January 2022 to October 2022, 10 plasma samples from patients with thyroid papillary carcinoma diagnosed pathologically after surgery were involved. Among them, 6 cases had LNM. Plasma from 4 individuals with no LNM was collected as a control. We extracted exosomes by ultracentrifugation, and Ex-miRNAs were profiled using small RNA next-generation sequencing followed by differential expression analysis. Based on unsupervised hierarchical clustering, the exosomal miRNAs expression profile in patients with LNMwas significantly different from the control group. Results: The results indicated that the levels of exosomal hsa-miR-1226-5p were significantly lower in the LNM group compared with nonmetastatic controls (p-value<0.05), whereas hsa-miR-145-5p, hsa-miR-1226-3p, hsa-miR-4745-5p, hsa-miR-673,5-5p, and hsa-miR-6821-5p were significantly higher in the LNM cases than in lymph node-negative group(p-value＜0.05). Ex-miRNAs cargo was profiled with microarrays followed by bioinformatics analyses. Their predicted target genes involved several cancer-related pathways, including Rap1 signaling pathway, cAMP signaling pathway, Calcium signaling pathway, Hippo signaling pathway, and ECM-receptor interaction (p-value<0.05).
Conclusions: Patients with LNM represent unique plasma exosomal miRNA profiles. Some abnormally expressed Ex-miRNAs can be identified as potential biomarkers for predicting PTC LNM.
Thin films ZnO-QDs Synthesis applying simultaneously the techniques of colloidal synthesis and sol gel and phenomenon at Zn2+→Zn3+ + e- charge transfer, applied to Shottky diode.
Authors: Garrido M. A. Vicencio , Portillo M. Chávez , Ramírez N. Carlos , Santiesteban H. Juárez , Téllez V. Carranza , Robledo–Taboada Luis Humberto 
Published: May 2023

Abstract

The Zinc Oxide and the Quantum dots of ZnO (ZnO-QD´s) in thin solid films were deposited by dropwise method on glass substrates and calcined in air atmosphere at temperatures of 60 °C, 100 °C, 140 °C, 160 °C and 210 °C, respectively. The samples are examined applying the techniques: Scanning Electron Microscopy (SEM), x-Ray Diffraction (XRD), Fourier transforms in the Infrared (FTIR), Photoluminescence (PL), Transmittance (%T), and absorbance (α). Tauc model, the band gap (Eg) energy is evaluated. The electrical measurements of Current-Voltage (I-V), the concentration of charge carriers, mobility and Resistance, are registered by Hall Effect. The morphology of the layers shows a structural configuration with stacked compact plates and flakes-like of crystalline conglomerates with a fibrous appearance. The films show a Wurtzite-type crystalline phase according to the XRD diffractograms. The grain size increased by ~3.6-26.1 nm. The dislocation density (δ) presents a gradual increase with the calcination temperature δ(lines/m2) ~1.57 x 1015-2.22 x 1015. On FT-IR spectroscopy analysis, various vibrational bands are associated with the CO32 ion and by-products generated by the hydrolysis of zinc acetate di-hydrate discussed. The Eg undergoes oscillatory and disorderly shifting towards higher photon energy, caused by faults at crystalline lattice of Eg ~3.7-3.87 eV. In optical analysis, the discontinuity located at UV-Vis region is associated in principle at Zn2+→Zn3+ + e- charge transfer. PL spectra at UV-Vis region records the emission bands with different relative intensity. The asymmetric Gaussian curve is associated with intrinsic defects in the crystal lattice. The deconvolution of the Gaussian curve generates different emission bands assigned to: red (RE) at ~770 nm, blue (BE), green (GE) at ~492-520 nm and yellow (YE) at ~570-600 nm. The study and systematic construction of the Schottky diode is done by placing the corresponding thin film on ITO, then PEDOT: PSS was placed, then the silver contact and finally the p-n junction was identified, obtaining better results than QD's ZnO in the Shottky diode plot.
Survival outcomes of esophageal cancer patients with recurrence after curative treatments
Authors: Sugawara Kotaro , Oka Daiji , Hara Hiroki , Yoshii Takako , Ushijima Hiroki , Kudo Shigehiro , Fukuda Takashi 
Published: May 2023

Abstract
Background: Little is known about predictive factors for survival outcomes of esophageal carcinoma (EC) patients who developed recurrence after undergoing multimodal therapies. We aimed to investigate long-term outcomes and identify prognostic factors in patients with relapsed EC, focusing especially on those with oligometastasis (OM).Methods: EC patients who developed recurrence after curative treatments (radical esophagectomy or definitive chemoradiotherapy (dCRT)) between 2010 and 2017 were reviewed. Multivariate Cox hazards models were applied to determine independent predictors of poor post-recurrence survival (PRS).Results: In total, 178 patients were included. The median PRS was 12.9 months. Of the 178 patients, 98 had OM and 80 non-OM (NOM) disease. The survival outcomes of patients with OM were significantly better than those of patients with NOM (P < 0.01). Surgical treatments provided significantly better survival outcomes than CRT or chemo-/radiotherapy alone (3-year overall survival (OS); 78.1% vs. 42.5% vs. 28.9%, P < 0.01), mainly due to prolonging survival after the recurrence (3-year PRS 62.9% vs. 16.7% vs. 16.2%, P < 0.01). Multivariable analysis focusing on patients with OM revealed cStage III-IV disease (P < 0.01), high GPS at the time of recurrence (P = 0.02) and non-curative treatments (P < 0.01), to be independently associated with poor PRS. In contrast, in patients with NOM, no independent predictors for poor PRS were identified.Conclusions: The survival outcomes of patients with relapsed EC remain poor. Surgical treatments provided significantly better survival outcomes than other treatment modalities, especially in patients with OM, mainly due to prolonging survival after the recurrence.
Development and validation of prediction model for the prognosis of critically ill patients with sudden cardiac arrest
Authors: Deng Han , Cai Jiaqi , Yang Haoyu , Yanxiaoxiao Yang , Chen Long , Bai Hao , Zheng Guanhao 
Published: May 2023

Abstract
Background
Sudden cardiac arrest (SCA) is an emerging threat to public health because of its high morbidity and mortality. Therefore, it is vital to develop a helpful clinical tool for predicting the prognosis of patients with SCA after successful resuscitation.
Methods
Critically ill patients who received successful resuscitation after SCA according to the Medical Information Mart for Intensive Care Database IV version 2.0 were enrolled. All eligible patients were divided into training and validation cohorts in a 7:3 ratio. Univariate analysis and stepwise multiple Cox regression were used to identify significant variables and construct a final prediction model. The decision curve, calibration curve, and receiver operating characteristic (ROC) curve were used to verify the performance of the current model.
Results
A total of 1001 patients were eligible for our study; 701 patients were distributed in the training cohort and 300 in the validation cohort. We found that alkaline phosphatase, age, anion gap, glutamic oxaloacetic transaminase, base excess, urea nitrogen, creatinine, glucose, metamyelocytes, neutrophils, partial pressure of carbon dioxide, potassium ions, and race were significant independent risk factors. A nomogram was established to predict the prognosis of SCA patients. The areas under the ROC curve (AUC) for 1-year, 3-year and 5-year were 0.827, 0.785, and 0.786, respectively, in the training cohort, while the corresponding AUC were 0.752, 0.723, and 0.686, respectively, in the validation cohort.
Conclusions
Taking into consideration the good predictive performance, our nomogram provides accurate prognostic information for patients accurately, which could help clinicians employ personalized treatment for high-risk patients and improve their clinical outcomes.
Swarm Optimized Deep Learning Scheduling in Cloud for Resource-intensive Iot Systems
Authors: Shingne Harshala , Shriram R 
Published: May 2023

Abstract

The paradigm Internet of Things (IoT) connects several million devices that can gather information which is stored and processed in the Cloud. This data is analyzed for inferring knowledge and performing predictions and analysis. Generally, in the cloud platform, users are charged based on the resources for storage and computing used. For real-world scheduling applications, these machines are not always available during certain periods of time owing to their stochastic or deterministic causes. The problem of cloud computing scheduling can be as challenging as the Non-deterministic Polynomial (NP) optimization problem, which can be an NP-hard problem. The continuous development in cloud computing and its complexity have made the problem even more challenging. Also, the problem of scheduling optimization is becoming an indispensable topic in academia. In this paper, a new hybrid metaheuristic technique based on Firefly Algorithm (FA), Particle Swarm Optimization (PSO) and Tabu Search (TS) is proposed to enhance task scheduling in resource intensive IoT systems. For the proposed algorithm, there can be a new and complete scheme to handle the task scheduling problems that were designed. To this, the TS algorithm can be incorporated aiming to lookout for the local optimum of every individual. For the purpose of improving solution quality, in every hybrid algorithm step, there has been an effective heuristic that has been proposed. This heuristic can bring down the other overtime costs by means of efficiently using the slack of the operation. Deep Reinforcement Learning (DRL) can be employed to solve problems in resource allocation and time scheduling thus making it easy to handle several tasks and resource heterogeneity. The experimental results demonstrated that the proposed methods (PSO-TS & FA-TS) achieved better performance compared to the other methods.
Study on non-targeted metabolomics of intestinal tract of DEV- infected ducks
Authors: Haiqing Cai , Xia Yang , Yunyun Yang , Yi Feng , Anlin Wen , Ying Yang , Ming Wen , Deyuan Ou 
Published: May 2023

Abstract
Introduction
Duck enteritis virus (DEV) mainly causes infectious diseases characterized by intestinal hemorrhage, inflammation and parenchymal organ degeneration in ducks and other poultry. However, its mechanism of intestinal damage in ducks is not well understood. Metabolomics can provide an in-depth understanding of the full complexity of the disease.
Methods
In this study, 24 clinically healthy green-shell ducks (weight 1.5kg ± 20g) were randomly divided them into 2 groups (experimental group of 18 rats and control group of 6 rats). The experimental group was intramuscularly injected with 0.2 mL of DEV virus liquid (TCID50 is 3.16×10 -9 /0.1 mL), and the control group was injected with 0.2 sterilized normal saline. mL; at 66 h, 90 h and 114 h after injection (fasting for 12 h before killing), tissue samples from the duodenum and ileum were collected and analyzed by LC-MS.
Results
Compared with the control group, in the positive/negative mode, the metabolic pathways involved in the differential metabolites in the duodenum of DEV-infected ducks at 66h, 90h and 114h were basically the same; the metabolic pathways related to inflammatory response and immune response were tryptophan Acid metabolism, cysteine-methionine metabolism, histidine metabolism and other amino acid metabolism and fat metabolism. Among them, the metabolic pathways with more differential metabolites are amino acid biosynthesis, cysteine and methionine metabolism, tryptophan metabolism, Unsaturated fatty acid biosynthesis and purine metabolism, the metabolic pathways with more enrichment factors were IgA-related intestinal immune network pathway and lysosome pathway. Compared with the control group, there were 16 differential metabolites in the ileum tissue of DEV-infected ducks at 66 hours of infection, 52 at 90 hours of infection, and 40 at 14 hours of infection with TD114, among which the metabolic pathways with more enriched differential metabolites were Pyrimidine metabolism, tyrosine metabolism, phenylalanine metabolism and tryptophan biosynthesis, the metabolic pathways with more enrichment factors are mTOR signaling pathway, ferroptosis pathway, tryptophan metabolism pathway and caffeine metabolism pathway
Conclusion
The differential metabolites of DEV-infected ducks are enriched in metabolic pathways such as tryptophan metabolism, amino acid biosynthesis, cysteine-methionine metabolism, unsaturated fatty acid biosynthesis and purine metabolism, among which tryptophan metabolism pathway The enrichment is the most obvious and can be used as a follow-up study;
Instagram Advertisements for Sun Protection Products: A Spectrum to be Broadened
Authors: Mansour Meghan R. , Sesi Jenna M. , Nessel Trevor , Kartono Francisca 
Published: May 2023

Abstract
Instagram is the most downloaded app globally, with billions of active users. Instagram has evolved to encompass several categories of posts, including advertisements. Users below the age of 24 make up 38.6% of total Instagram users, and the United States Preventive Services Task Force recommends counseling patients about decreasing the risk of skin cancer by minimizing exposure to ultraviolet radiations, especially for ages 6 months to 24 years. Users are more likely to connect with advertisements in which they feel represented; therefore, it is important that the sun protection (SP) advertisements on the application are inclusive of all races and genders. The purpose of our study was to analyze the quality of advertisements on the Instagram profiles of common SP brands. The thirty most recent product-related posts on Instagram profiles of common SP brands were analyzed. Results revealed Fitzpatrick skin types IV-VI are poorly represented in the Instagram posts of SP brands, totaling only 35.5% of featured people. Additionally, only 19% of the total posts including males. There is a documented misconception amongst people of color that the use of SP to prevent skin cancer and photoaging is unnecessary. Additionally, there is a greater incidence of skin cancer in males, which may be attributed to less SP use than females. With advertisements expanding to easily accessible applications like Instagram, it would be beneficial to determine avenues to improve representation within these advertisements to promote patient compliance with SP products.
Prevalence and factors associated with small for gestational age among women who delivered at Hoima Regional Referral Hospital, Western Uganda: A cross-sectional study.
Authors: Kumbakulu Patrick Kumbowi , Nherera Rosaria 
Published: May 2023

Abstract
Background: Small for gestation age (SGA) is a common problem in low and middle income countries (LMIC) and has important adverse effects on subsequent survival, health, growth and development independently of the gestational age. The complications of SGA occur during the neonatal period, throughout childhood and beyond.
Methods: A descriptive and analytical cross-sectional study was conducted to determine the prevalence and factors associated with SGA among women who delivered at the maternity ward of Hoima Regional Referral Hospital (HRRH). Data was collected from August to October 2022 using questionnaire interview and physical examination. SGA was defined as a birthweight lower than the 10th centile for a specific completed gestational age by gender, using the Alexander reference population. Data was analysed using SPSS 27.0 statistics for windows. The prevalence of SGA was determined as proportion, whereas binary logistic regression was used to determine factors associated with SGA. A p-value <0.05 was considered for statistical significance both at bivariate and multivariable level.
Results: Of the 236 participants, 44(18.6%) were SGA. SGA was dependent of positive HIV serologic status [p=0,01; aOR 5.41(2.99-9.80)], undernutrition [p=0,001; aOR 3.22(1.95-5.33)], oligohydramnios [p=0,02; aOR 1.83(1.01-3.31)], and prematurity [p=0,02; aOR 2.87(1.21-6.82)].
Conclusion: The prevalence of SGA was relatively high among women who attended HRRH. HIV, undernutrition, oligohydramnios, and prematurity were consistently associated with the occurrence of SGA births. HIV prevention and care, antenatal visits, and good feeding practices among pregnant women are vital interventions to reduce the prevalence of SGA.
The application of magnetically controlled capsule endoscopy in gastrointestinal bleeding patients
Authors: Xiao Xue , Zeng Yu , Xing Xiaocun , Shen Ming , Yang Jinlin 
Published: May 2023

Abstract
Background
Magnetically controlled capsule endoscopy (MCCE) could simultaneously complete the observation of gastric and small bowel mucosa in one examination. It could not support therapeutic procedure. We aimed to evaluate the application of magnetically-control capsule endoscopy in gastrointestinal bleeding patients.
Methods
We reviewed the data of patients that finished MCCE in West China hospital, Sichuan University between 2021 January to 2021 December. In total of 123 patients, 50 complained of gastrointestinal bleeding symptoms were included. All patients’ data including gastrointestinal bleeding symptoms, comorbidities, drug history and laboratory test results were collected and analyzed.
Results
In all the patients, 92% patients had overt gastrointestinal bleeding symptoms, including melena (50%) and hematochezia (42%). The average hemoglobin concentration was 82.44 ± 17.33 g/L, and the median Glasgow-Blatchford score (GBS) was 8. Before MCCE examination, 28% patients had not received any endoscopic screening due to severe comorbidities, and the remaining 72% was considered as obscure gastrointestinal bleeding. MCCE detected gastrointestinal lesions in 96% patients, in which, 68% patients showed active bleeding lesions or recent hemorrhage stigmata during examination, including upper gastrointestinal lesions in 4 cases, small bowel lesions in 30 cases and colonic lesion in 1 case. In the other cases without bleeding signs, MCCE detected small bowel lesions in 11 cases, upper gastrointestinal lesions in 2 cases and colonic lesion in 1 case. All the patients finished both gastric and small bowel screening in one time. There were no side effects in all the patients during or after the MCCE examination, including emergency endoscopy intervention.
Conclusions
MCCE is available and safe in gastrointestinal bleeding patients with symptoms of melena, hematochezia, fecal occult blood positive and iron deficiency anemia of unknown origin.