bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
Authors: Huang Xiaogang , He Xiongzhi , Qiu Rongxian , Xie Xuemei , Zheng Fengfeng , Chen Feihua , Hu Zhenting 
Published: June 2023

Abstract
Unfolded protein response (UPR) plays an important role in the pathogenesis of many liver diseases. BMI1 has a liver protection effect, but whether it participates in the regulation of hepatocyte death through UPR is not well defined. Herein, the endoplasmic reticulum stress model was established by inducing hepatocyte line (MIHA) with tunicamycin (TM, 5 µg/ml). Cell counting kit-8 assay and flow cytometry were used to evaluate the viability and apoptosis of hepatocytes. The expression levels of BMI1, KAT2B, and proteins related to UPR (p-eIF2α, eIF2α, ATF4, and ATF6), NF-κB (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-MLKL and MLKL) were determined by Western blot. The relationship between KAT2B and BMI1 was determined by co-immunoprecipitation and ubiquitination assay. The results showed that TM not only promoted UPR, apoptosis, and necroptosis in hepatocytes but also upregulated the expression levels of BMI1 and KAT2B and activated NF-κB pathway. BAY-117082 reversed the effects of TM on viability, apoptosis, NF-κB pathway, and BMI1 but strengthened the effects of TM on KAT2B/MLKL-mediated necroptosis. BMI1 promoted the ubiquitination of KAT2B, and BMI1 overexpression reversed the effects of TM on viability, apoptosis, and KAT2B/MLKL-mediated necroptosis. In summary, overexpression of BMI1 promotes the ubiquitination of KAT2B to block the MLKL-mediated necroptosis of hepatocytes.
Relations between PTSD symptom clusters and pain in three trauma-exposed samples with pain
Authors: Åkerblom Sophia , Cervin Matti , Nordin Linda , Andersen Tonny Elmose , Thøgersen Marie Høgh , Perrin Sean 
Published: June 2023

Abstract

Objectives
Little is known about how the individual PTSD symptom clusters relate to intensity and interference of pain and whether these relationships differ across clinical groups. The present study examines relations between PTSD symptom clusters and pain in three trauma-exposed, unique clinical groups: 1) adults seeking treatment for chronic pain with current symptoms of PTSD, 2) trauma affected refugees seeking treatment for PTSD and chronic pain; and 3) individuals identified at admission to the emergency ward after whiplash injury.

Methods
Network analysis was used to assess unique relations between pain intensity, pain interference, re-experiencing, avoidance, numbing, hyperarousal, depression, and anxiety separately in each sample. Links between PTSD clusters and pain were then compared within and between samples.

Results
No within-group differences were identified for the links between pain and any of PTSD clusters in the chronic pain and refugee groups. In the whiplash group, hyperarousal was more strongly related to pain than re-experiencing, avoidance, and numbing. Between group comparisons revealed a more pronounced relationship between hyperarousal and pain in the whiplash group, with no between-group differences between the chronic pain and refugee groups.

Conclusions
The findings suggest that when depression and anxiety are accounted for, few unique associations are found between pain and the PTSD symptom clusters in trauma-exposed samples with pain, with the exception of a link between pain and hyperarousal in individuals with whiplash-related PTSD symptoms.
Development of a comprehensive method for assessing the efficiency of human resources staffing of organizational and state structures
Authors: Dudnyk Volodymyr , Tikhonov Hryhoriy , Rudenko Dmytro 
Published: June 2023

Hierarchical construction of the human resources system, constant change in the forms and methods of armed struggle requires taking into account a large number of factors. At the same time, each of the factors is described by evaluation indicators of different origin and measurement units. This, in turn, requires the use of modern and proven mathematical apparatus, which is capable of processing a large array of various types of data with a given reliability of management decision making in a short period of time. In the course of the conducted research, classical methods of analysis were used to solve the problem of analyzing the conditions and factors affecting the effectiveness of the human resources staffing system. The theory of artificial intelligence was also used to process various types of data in the course of evaluating the effectiveness of the human resources staffing system. The object of the research is the system of staffing with human resources. The subject of the research is the effectiveness of the system of staffing with human resources. In the research, the development of a complex method for evaluating the effectiveness of staffing the organizational and state structures with human resources was carried out. The novelties of the research are:
– evaluation of the possible risks of disruption of the task of staffing with human resources in the responsibility area;
– determination of influence of indicators of the effectiveness of the human resource recruitment system on each other;
– determination of influence of a group of indicators for evaluating the efficiency of the human resources system on a separate indicator.
It is expedient to implement the specified method in algorithmic and program software while researching the state of the system of staffing with human resources during the formation of new or additional staffing of existing organizational and state structures.
Recycling of siliceous by-products to reduce their impacts on the environment
Authors: Bouabdallah Soufiane , Chaib Abdeslam , Bounouala Mohamed , Dovbash Nadiia , Benselhoub Aissa , Bellucci Stefano 
Published: June 2023

Currently, there is a tendency to use less silica rich ores given the depletion of high-quality resources. The raw kaolin treatment of Tamazert (Eastern Algeria) produces, by hydrocyclone process, approximately 80 % of siliceous by-products. These siliceous wastes, which are stored in the open air, constitute a significant environmental problem. This research work aims to improve the quality of siliceous by-products, more particularly, to a process for the elimination of iron oxides and aluminum to make this raw material usable industrially as well as solving environmental issues. The collected by-products, were characterized by different techniques, such as X-ray fluorescence (XRF) and X-ray diffraction (XRD). XRF confirmed that the by-products east siliceous, with content going up to 82 % of SiO2. The by-product resulted from the raw kaolin treatment, mainly contains varying amounts of impurities such as iron oxide, titanium oxide and alumina. In all cases, the presence of these impurities affects the color and the physical properties of the mineral, and so lowers the economic value and limits the industrial application. In this framework, the classified fraction (–500)–(+100) µm was directed to attrition scrubbing followed by magnetic separation technique and chemical treatment by sulphuric acid with different concentrations. The results of the beneficiation tests of by-product indicate that using the attrition scrubbing alone not provides a suitable product for glass manufacture. The magnetic separation was tested with attrition on the useful fraction ((–500)–(+100) μm). The non-magnetic attritional fraction concentrates less than 0.45 % of Al2O3 and 0.05 % of Fe2O3. This low content coupled with a remarkable percentage in silica of 97.98 %.The tests by attrition and leaching with 40 % of sulphuric acid show, on the one hand, significant results with a high percentage of silica (>98.5 %) against 0.04 % Fe2O3 and 0.66 % Al2O3 ,and on the other hand, that the enriched product meets the standards required by glass making.
Technology of protein isolate from peas (Pisum sativum var. arvense)
Authors: Golovko Tetyana , Golovko Mykola , Vasilenko Olha , Pertsevoi Fedir , Bolgova Natalia , Tischenko Vasyl , Prymenko Vladyslav 
Published: June 2023

The object of research is pea (Pisum sativum var. arvense) and pea protein isolate. The chemical composition of pea (Pisum sativum var. arvense) was studied to determine its potential as a new raw material for obtaining protein isolate by pH-shifting treatment. The obtained results confirm the effectiveness of using peas to obtain protein isolate for use in the food industry instead of soy protein isolate. Peas are low in lipids (1.61 % on dry matter), high in crude protein (19.21 % on dry matter), ash (3.41 % on dry matter) and minerals (Se, Fe, Zn, Mn, Cu, Mg, P). The ratio of essential amino acids to replaceable amino acids (0.78), which is higher than the amount recommended by the World Health Organization. Vegetable protein is an alternative to animal protein in the food industry. Protein isolate from peas was obtained by pH-shifting treatment and its chemical composition and functional properties were determined. After pH-shifting treatment, the chemical composition of protein and mineral substances did not show significant changes. The protein content of pea protein isolate was 82.2 %, and the yield of pea protein isolate was 5.6 %. To confirm the functional properties of pea protein isolate, the indicators of moisture-holding capacity (1.05 ml/g) and fat-holding capacity (0.82 ml/g) were investigated. Peas and protein isolate from it showed high functional properties and high-quality chemical composition of proteins and minerals for use in the technology of sausage products, which should be the focus of further research.
The Issue of Dual-Morphemes in Arabic: A Morpho-Syntax Study
Authors: Yumanto Mochammad Indra , Mohammad Nurunnasry  , Abdoul Jabalibizmungu  
Published: June 2023

This research aims to find out the different arguments and opinions about the Morpheme “Tatsniyah”. The research combined morphological and structural studies in their analysis of the placement of words in the sentence, and the method used by the researcher in this issue is the descriptive approach, where the researcher described the problematic facts of the Morpheme “Tatsniyah” in the Arabic language. The result of this study are The first, opinions of nahwu scholars on the morpheme “Alif” in “Tatsniyah” : (a) the morpheme “Alif” is the letter “I’rob”. (b) the morpheme “Alif” is “I’rob”. (c) the morpheme “Alif” is the proposition “I’rob”. (d) the morpheme “Alif” is “Mabni”. (e) the morpheme "Alif" is not to be confused with "isim". (f) determining the morpheme "Alif" in the situation of "rofa', nashab, and jer". The second, function of the "nun" morpheme in “Tatsniyah”: (a) substitute for “harakat” and “tanwin”. (b) substitute for “harakat”. (c) substitute for “tanwin”. (d) address for the absence of “idhofah”. The third, determinations of the “Tatsniyah” morpheme are seen from several aspects: (a) from the aspect of its use, (b) from the aspect of word classification, (c) from the aspect of its affixation.
The Levels of Modern Standard Arabic in Egypt and its Role in Arabic Language Teaching for Indonesian
Authors: Nur Hidayatun Na'imah  , Mirwan Ahmad Taufiq  , Kholifiatul Masito  
Published: June 2023

This study aims to reveal the importance of knowing the five levels of Modern Standard Arabic in Egypt. This study used a qualitative method with literature study through book references, dictionaries, and journals. The main object of this study is the Arabic language itself and its role in Arabic language teaching for Indonesian. The data were collected through interviews and documentation from some students in State Islamic University Sunan Ampel in Surabaya and Al-Azhar University in Cairo to get data from the reality. Then, the result of this study revealed that the level of Modern Standard Arabic in Egypt is important to know for Indonesian Arabic language learners in order to understand many forms of language in various situations and conditions as well as the existing kinds of literature such as in scientific forums up to daily conversations because it can represent the varieties of Arabic existing in other countries and to add the knowledge of Arabic literature by learning about colloquial language and linguistic phenomenon about it in Arabic teaching.

هدف هذا البحث إلى معرفة خمس مستويات اللغة العربية المعاصرة. تناول هذا البحث المنهج الكيفي بجمع البيانات حول الكتب والمعاجم والبحوث. وتركيز محور الدراسة هو اللغة العربية نفسها ودورها في تعليم اللغة العربية مع الظواهر اللغوية، والمحور الثاني هو الظواهر اللغوية التي تسبب هذه المستويات، طريقة جمع البيانات هي المقابلة مع بعض الطلاب الإندونيسيين بجامعة سونن أمبيل الإسلامية الحكومية سورابايا وجامعة الأزهر الإسلامية بالقاهرة. فنتائج الدراسة هي أن معرفة تقسيم اللغة العربية إلى خمسة مستويات مهمة لتساعد الإندونيسيين في فهم عدة صيغ من اللغة العربية إما الفصحى والعامية وتزويد المعلومات عن الثقافة العربية بتعيين العامية في تعليم اللغة العربية مع الاهتمام إلى الظواهر اللغوية تتعلق بهذه اللغة.
Content Analysis of Arabic Language Textbook for Tenth Grade Based On Curriculum 2013
Authors: Abd Latif  , Ellina Dwi Faning Zun  
Published: June 2023

Content analysis is a method to study and analyse something systematically and objectively against the message that appears. The content of textbooks is a source of material in the learning process. Therefore, textbooks must follow the applicable curriculum. This study seeks to find the contents of qirā'ah and kalam in the Arabic language book for students of the 2013 curriculum for class X Madrasah Aliyah published by the Ministry of Religion and its conformity with the 2013 curriculum, which consists of four Core Competencies (KI) which are the perspectives. This research used a descriptive-qualitative approach using documentation and content analysis methods as a tool for collecting and analyzing data. The results of this study indicate that the content of qirā'ah and kalam is under the content standards (KI) of the 2013 Curriculum. The details are as follows: 1) The first and second chapters are more prominent in the realm of social attitudes (KI 2) and spiritual (KI 1), and chapters three and four are more prominently in the realm of social attitudes (KI 2) and skills (KI 4), and chapters five and six more in the realm of spiritual attitudes (KI 1) and knowledge (KI 3). Meanwhile, the material does not cover diversity, tolerance, pluralism, and multiculturalism.
Efficacy and safety of curcumin in patients with metabolic phenotype of osteoarthritis: A pilot study
Authors: Shirinsky I. V. , Shirinsky V. S. , Filatova K. Yu. 
Published: June 2023

The aim of this study was to assess efficacy and safety of curcumin in metabolic syndrome- associated osteoarthritis (MetS-OA). All patients provided written informed consent. Knee OA was diagnosed according to American College of Rheumatology criteria; MetS was diagnosed according to Russian Scientific Society of Cardiology Guidelines. The study had before-and-after design. The main inclusion criteria were presence of knee OA and MetS, levels of global health assessment and pain assessment more than 50 mm using 0-100 visual analogue scale (VAS). The main outcome was VAS global. The other outcomes were VAS pain, Knee injury and Osteoarthritis Outcome Score (KOOS) consisting of five subscales: pain (KOOS pain), other symptoms (KOOS symptoms), activities in daily living (KOOS ADL), function in sport and recreation (KOOS Sport/Rec) and knee related Quality of life (KOOS QoL). The level of depression was measured using PHQ- 9. For pain, proportion of patients achieving minimal clinically important improvement (MCII) was assessed using the cut-offs of (a) 15 of 100 for absolute improvement and 20% for relative improvement.The treatment consisted of C. longa extract 1000 mg/day for 4 weeks. The assessments were performed on baseline and 4 weeks thereafter. Eighteen women with MetS-OA of the knee were included in the study.At the end of treatment, there were significant improvements in the VAS global scale by an average 33.9 mm (p = 0.001), VAS pain by 25 mm (p = 0.001). There was a trend towards improvement in PHQ-9 by 2.9 (p = 0.05). The mean improvement in KOOS pain was 11 (p = 0.001). KOOS symptoms improved by 9 (p = 0.025), KOOS ADL - by 12.4 (p = 0.001), KOOS Sport/Rec by 10.3 (p = 0.044), and KOOS QOL by 14.4 (p = 0.009). The proportion of patients achieving clinically significant improvement (MCII) were nine (56%) for both global health and pain. There were no adverse events during the study. The findings of this study suggest clinical efficacy and safety of C. Longa in MetS-associated knee OA. There is a need for large controlled studies to confirm these results.
Functional activity of the monocyte immune link in gastric adenocarcinoma
Authors: Smirnova O. V. , Ovcharenko E. S. 
Published: June 2023

Stomach cancer is in the top ten in terms of prevalence and ranks 4th in terms of causes of death worldwide. The most common and most aggressive variant of gastric cancer is adenocarcinoma. The monocytic link of immunity provides the main line of the body's fight against malignant cells, while in patients with adenocarcinoma it is insufficiently studied. The purpose of the study was to evaluate the functional activity of monocytes in patients with gastric adenocarcinoma at different stages of the disease.Individuals (n = 164) were examined, among whom 85 were diagnosed with stage I-IV stomach adenocarcinoma. The study also involved 79 apparently healthy donors. The functional activity and oxygen-dependent phagocytosis of monocytes were assessed by the chemiluminescent method. Luminol was used as a chemiluminescence inducer. The respiratory burst was activated with opsonized zymosan.In patients with stomach adenocarcinoma, at rest (spontaneous chemiluminescence), an increase in the time the curve reached the maximum intensity of chemiluminescence (Tmax = 7957 s), the area under the chemiluminescence curve (Squr = 0.2 x 106), the activation index (1.89 c. u.) and a decrease in the maximum value of chemiluminescence intensity (Imax = 424 c. u.) relative to the control group (Tmax = 5533 s, Squr = 0.011 x 106, activation index = 0.88 c. u., Imax = 424 c. u., p < 0.05) were seen. When chemiluminescence is induced in patients with stomach adenocarcinoma, a statistically significant predominance of Squr is fixed (0.46 x 106, in the control group Squr = 0.031 x 106). Also, in the group of patients with stomach adenocarcinoma, monocytic phagocytosis was reduced by more than 2 times (29% vs 84% in the control group, p < 0.05). When analyzing the studied parameters, depending on the stage of the disease, it was found that the violation of the chemiluminescent reaction in patients with stomach adenocarcinoma is fixed already at an early stage. At the same time, in patients with stage IV stomach adenocarcinoma, the indicators of spontaneous and induced chemiluminescence are more than 2 times different from those in the control group and patients at stage I of the disease. The identified features indicate a decrease in the effectiveness of immune reactions of the monocytic link in stomach adenocarcinoma already in the early stages of the disease and can be used to detect early signs of immune disorders and optimize therapeutic approaches in this disease.
Features of the blood cytokine profile in gastroesophageal reflux disease in schoolchildren with gastritis and family history of peptic ulcer
Authors: Polivanova T. V. , Vshivkov V. A. , Akhmetshin T. N. 
Published: June 2023

Gastroesophageal reflux disease (GERD) is a common acid-dependent disease among the population, including children, with multifactorial genesis. It, like many other acid-dependent diseases (peptic ulcer, etc.) is associated with a family predisposition to the disease. Of interest is the study of the role of cytokines in the regulation of pathology in childhood, depending on the severity of a family history of peptic ulcer disease. Aim: to evaluate the levels of cytokines in the blood serum in case of family history of ulcerative diseases in schoolchildren with gastritis associated with GERD. In the course of a scientific study, 142 children with gastroenterological complaints aged 7-17 years were examined. The diagnosis of GERD was made in the presence of weekly heartburn in accordance with the global consensus on pathology in children. All subjects underwent gastroscopy with taking biopsy material from the gastric mucosa and morphological confirmation of their diagnosis of gastritis in accordance with the Sydney classification. The concentration of cytokines in blood serum (IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IL-1β, IFNα, TNFα) was obtained by enzyme immunoassay. During statistical processing, the χ2 and Mann–Whitney tests were used. The studies were approved by the ethics committee and informed consents of patients and their parents were obtained prior to the start of the study. The results of the study did not show significant differences in the concentration of cytokines in schoolchildren depending on the presence of GERD. In children with a family burden of peptic ulcer, GERD was detected more often (p = 0.054), which is probably a consequence of their increased acid formation. Changes in the cytokine profile of the blood were noted. During GERD, with aggravation of peptic ulcer, there was an increase in the replication of IL-4 (p = 0.027) and IFNα (p = 0.001). The increase in blood IFNα in children with GERD with family burden is obviously aimed at enhancing immune responses involving the whole body to damage. This is due to its functional role – participation in the immune response. Increased replication of IL-4, obviously, provides an increase in metabolic, immune processes in the body aimed at optimizing the course of proliferative processes in the esophageal mucosa under conditions of increased secretion of hydrochloric acid in the stomach. Thus, when a family history of peptic ulcer is aggravated in schoolchildren with gastritis associated with GERD, a number of links in the cytokine network (IL-4, IFNα) move to the systemic level of regulation.