bluuebunny/crossref_metadata_2025_split huggingface dataset:
Façadism, Building Renovation and the Boundaries of Authenticity
Authors: Kyriazi Evangelia 
Published: December 2022

The paper presents the history and trends of façadism, with examples from around the world, including a case where the State intervened for the suspension of façadism plans after alarmed academics referred to the Supreme Administrative Court. The different practices and scopes of façadism are presented, along with the views of its supporters and adversaries. Issues of authenticity arising from façadism interventions are discussed. Answers on whether building renovation through façadism consists of cultural preservation practice and preservation of the authenticity of a place, are sought in internationally accepted cultural heritage policy documents. These may provide solutions that could assist countries and institutions to make the right decisions regarding the conservation of architectural heritage, and confront extreme façadism practices through planning programs, legislative measures and education.
What Ever Happened to Anti-Essentialism?
Authors: McFee Graham 
Published: December 2022

How should one explain the relative disappearance of a major preoccupation of English-speaking Analytical Philosophy in the late 1950s/early 1960s: an anti-essentialist response to the question, ‘What is art?’, typified in papers by Kennick and Weitz? Minimally, anti-essentialism denies the widely-held assumption that something must be in common between all the instances where (in our case) the term “[fine] art” or the concept art is rightly ascribed, in virtue of which all are called ‘art’; a stronger version urges that, in fact, there is no essence to (our example) art.
Procalcitonin for antimicrobial stewardship among cancer patients admitted with COVID-19
Authors: Dagher Hiba , Chaftari Anne-Marie , Mulanovich Patricia , Jiang Ying , Hachem Ray , Malek Alexandre E , Borjan Jovan , Viola George M , Raad Issam 
Published: December 2022

Background:Procalcitonin (PCT) has been used to guide antibiotic therapy in bacterial infections. We aimed to determine the role of PCT in decreasing the duration of empiric antibiotic therapy among cancer patients admitted with COVID-19.Methods:This retrospective study included cancer patients admitted to our institution for COVID-19 between March 1, 2020, and June 28, 2021, with a PCT test done within 72 hr after admission. Patients were divided into two groups: PCT <0.25 ng/ml and PCT ≥0.25 ng/ml. We assessed pertinent cultures, antibacterial use, and duration of empiric antibacterial therapy.Results:The study included 530 patients (median age, 62 years [range, 13–91]). All the patients had ≥1 culture test within 7 days following admission. Patients with PCT <0.25 ng/ml were less likely to have a positive culture than were those with PCT ≥0.25 ng/ml (6% [20/358] vs. 17% [30/172]; p<0.0001). PCT <0.25 ng/ml had a high negative predictive value for bacteremia and 30 day mortality. Patients with PCT <0.25 ng/ml were less likely to receive intravenous (IV) antibiotics for >72 hr than were patients with PCT ≥0.25 ng/ml (45% [162/358] vs. 69% [119/172]; p<0.0001). Among patients with PCT <0.25 ng/ml and negative cultures, 30 day mortality was similar between those who received IV antibiotics for ≥72 hr and those who received IV antibiotics for shorter durations (2% [2/111] vs. 3% [5/176], p=0.71).Conclusions:Among cancer patients with COVID-19, PCT level <0.25 ng/ml is associated with lower likelihood of bacterial co-infection and greater likelihood of a shorter antibiotic course. In patients with PCT level <0.25 ng/ml and negative cultures, an antibiotic course of >72 hr may not be necessary. PCT could be useful in enhancing antimicrobial stewardship in cancer patients with COVID-19.Funding:This research was supported by the National Institutes of Health/National Cancer Institute under award number P30CA016672, which supports MD Anderson Cancer Center’s Clinical Trials Office.
Future stem cell analysis: progress and challenges towards state-of-the art approaches in automated cells analysis
Authors: Mohamad Zamani Nurul Syahira , Wan Zaki Wan Mimi Diyana , Abd Hamid Zariyantey , Baseri Huddin Aqilah 
Published: December 2022

Background and Aims
A microscopic image has been used in cell analysis for cell type identification and classification, cell counting and cell size measurement. Most previous research works are tedious, including detailed understanding and time-consuming. The scientists and researchers are seeking modern and automatic cell analysis approaches in line with the current in-demand technology.

Objectives
This article provides a brief overview of a general cell and specific stem cell analysis approaches from the history of cell discovery up to the state-of-the-art approaches.

Methodology
A content description of the literature study has been surveyed from specific manuscript databases using three review methods: manuscript identification, screening, and inclusion. This review methodology is based on Prism guidelines in searching for originality and novelty in studies concerning cell analysis.

Results
By analysing generic cell and specific stem cell analysis approaches, current technology offers tremendous potential in assisting medical experts in performing cell analysis using a method that is less laborious, cost-effective, and reduces error rates.

Conclusion
This review uncovers potential research gaps concerning generic cell and specific stem cell analysis. Thus, it could be a reference for developing automated cells analysis approaches using current technology such as artificial intelligence and deep learning.
Spectroscopic Properties of a Biologically Relevant [Fe2(μ‐O)2] Diamond Core Motif with a Short Iron‐Iron Distance
Authors: Kass Dustin , Yao Shenglai , Krause Konstantin B. , Corona Teresa , Richter Liza , Braun Thomas , Mebs Stefan , Haumann Michael , Dau Holger , Lohmiller Thomas , Limberg Christian , Drieß Matthias , Ray Kallol 
Published: December 2022

AbstractDiiron cofactors in enzymes perform diverse challenging transformations. The structures of high valent intermediates (Q in methane monooxygenase and X in ribonucleotide reductase) are debated since Fe−Fe distances of 2.5–3.4 Å were attributed to “open” or “closed” cores with bridging or terminal oxido groups. We report the crystallographic and spectroscopic characterization of a FeIII2(μ‐O)2 complex (2) with tetrahedral (4C) centres and short Fe−Fe distance (2.52 Å), persisting in organic solutions. 2 shows a large Fe K‐pre‐edge intensity, which is caused by the pronounced asymmetry at the TD FeIII centres due to the short Fe−μ−O bonds. A ≈2.5 Å Fe−Fe distance is unlikely for six‐coordinate sites in Q or X, but for a Fe2(μ‐O)2 core containing four‐coordinate (or by possible extension five‐coordinate) iron centres there may be enough flexibility to accommodate a particularly short Fe−Fe separation with intense pre‐edge transition. This finding may broaden the scope of models considered for the structure of high‐valent diiron intermediates formed upon O2 activation in biology.
A review of Canadian wood conversion technologies for the production of fuels and chemicals
Authors: Sreekumar Arun , Mohan Omex , Kurian Vinoj , Mvolo Cyriac , Kumar Amit 
Published: December 2022

AbstractCanada has 347 million ha of forest cover, contributing to the potential large availability of wood‐based resources. Although Canada's forest sector contributed $23.7 billion to the national nominal gross domestic product (GDP) in 2019, the GDP contribution of the wood product manufacturing subsector shrank by 6%. To reposition the Canadian forest industry, new forest management practices and wood‐based conversion technologies should be applied. In this context, the use of woody biomass in biorefineries to produce clean energy, fuels, and chemicals is becoming increasingly significant. There is a need to understand the current status and challenges of the wood‐based biomass conversion technologies that have been and are being developed in Canada. This information will help decision‐makers in formulating and implementing forest sector‐related policies for a sustainable bioeconomy in Canada. This study is focused on a review of Canadian woody biomass conversion technologies. Our critical review identified considerable potential biomass conversion technologies specialized for woody feedstock, all in the Canadian setting. We focused on the prospects of revitalizing Canada's pulp and paper industry through the integration of pre‐treatment processes and biochemical technologies. The thermochemical conversion pathway was identified as the dominant route for woody feedstock valorization. The review also identified pathways with the potential to diversify the existing product mix that generate products from wood streams, such as chemicals and biomaterials. Most of the biochemical and thermochemical research done in institutional and multi‐institutional research collaborations from laboratory scale to industrial scale will boost the chances of the commercialization of a wood‐based biorefinery in Canada.
Simultaneous Sensing of H2O, D2O and HOD through Peroxo Vibrations
Authors: Pal Srimanta , Chattopadhyay Arun 
Published: December 2022

AbstractDetection of HOD simultaneously in the presence of a mixture of H2O and D2O is still an experimental challenge. Till date, there is no literature report of simultaneous detection of H2O, D2O and HOD based on vibrational spectra. Herein we report simultaneous quantitative detection of H2O, D2O and HOD in the same reaction mixture with the help of bridged polynuclear peroxo complex in absence and presence of Au nanoparticles on the basis of a peroxide vibrational mode in resonance Raman and surface enhanced resonance Raman spectrum. We synthesize bridged polynuclear peroxo complex in different solvent mixture of H2O and D2O. Due to the formation of different nature of hydrogen bonding between peroxide and solvent molecules (H2O, D2O and HOD), vibrational frequency of peroxo bond is significantly affected. Mixtures of different H2O and D2O concentrations produce different HOD concentrations and that lead to different intensities of peaks positioned at 897, 823 and 867 cm−1 indicating H2O, D2O and HOD, respectively. The lowest detection limits (LODs) were 0.028 mole fraction of D2O in H2O and 0.046 mole faction of H2O in D2O. In addition, for the first time the results revealed that the cis‐peroxide forms two hydrogen bonds with solvent molecules.
Self‐Activation of Inorganic‐Organic Hybrids Derived through Continuous Synthesis of Polyoxomolybdate and para‐Phenylenediamine Enables Very High Lithium‐Ion Storage Capacity
Authors: Mohamed Mana Abdirahman , Arnold Stefanie , Janka Oliver , Quade Antje , Presser Volker , Kickelbick Guido 
Published: December 2022

AbstractInorganic‐organic hybrid materials with redox‐active components were prepared by an aqueous precipitation reaction of ammonium heptamolybdate (AHM) with para‐phenylenediamine (PPD). A scalable and low‐energy continuous wet chemical synthesis process, known as the microjet process, was used to prepare particles with large surface area in the submicrometer range with high purity and reproducibility on a large scale. Two different crystalline hybrid products were formed depending on the ratio of molybdate to organic ligand and pH. A ratio of para‐phenylenediamine to ammonium heptamolybdate from 1 : 1 to 5 : 1 resulted in the compound [C6H10N2]2[Mo8O26] ⋅ 6 H2O, while higher PPD ratios from 9 : 1 to 30 : 1 yielded a composition of [C6H9N2]4[NH4]2[Mo7O24] ⋅ 3 H2O. The electrochemical behavior of the two products was tested in a battery cell environment. Only the second of the two hybrid materials showed an exceptionally high capacity of 1084 mAh g−1 at 100 mA g−1 after 150 cycles. The maximum capacity was reached after an induction phase, which can be explained by a combination of a conversion reaction with lithium to Li2MoO4 and an additional in situ polymerization of PPD. The final hybrid material is a promising material for lithium‐ion battery (LIB) applications.
Safety evaluation of Balanced Health Care Dan—A medicinal formulation containing traditional edible ingredients in lung tumor‐loaded mice
Authors: Dong Feng , Zhao Changhui , He Xiaoyun , Dong Yueyang , Liu Haiyan , Yao Peng , Xu Wentao 
Published: December 2022

AbstractChinese formulation‐based medicinal food has been widely used in clinical trials, but its safety is not well studied. In this research, the edible safety assessment of Balanced Health Care Dan—a formulation containing traditional edible ingredients that were initially formulated to reduce side effects for lung cancer patients—was studied in mice based on biochemical and gut microbial analyses. The experimental mice were subcutaneously loaded with lung tumor A549 cells and then administrated with Balanced Health Care Dan (200 mg/kg or 400 mg/kg b.w. in gavage feeding) for 4 weeks. The body weight, blood parameters, and pathogenic phenotype in tissues were examined. No toxicological symptom was found in experimental mice compared with the normal control. Comprehensive analyses were also conducted to evaluate intestinal microbiota that are associated with many diseases. Balanced Health Care Dan modified the gut microbiota structure in a positive way. In conclusion, the Chinese formulation‐based medicinal food has shown no toxicological effect in mice within 4 weeks of feeding experiment and has the potential to be used in clinical trials.
The role of selective SATB1 deletion in somatostatin expressing interneurons on endogenous network activity and the transition to epilepsy
Authors: Vasilopoulos Nikos , Kaplanian Ani , Vinos Michael , Katsaiti Yolanda , Christodoulou Ourania , Denaxa Myrto , Skaliora Irini 
Published: December 2022

AbstractSomatostatin (SST) expressing interneurons are the second most abundant group of inhibitory neurons in the neocortex. They mainly target the apical dendrites of excitatory pyramidal cells and are implicated in feedforward and feedback inhibition. In the present study, we employ a conditional knockout mouse, in which the transcription factor Satb1 is selectively deleted in SST‐expressing interneurons resulting to the reduction of their number across the somatosensory barrel field. Our goal was to investigate the effect of the reduced number of Satb1 mutant SST‐interneurons on (i) the endogenous cortical network activity (spontaneously recurring Up/Down states), and (ii) the transition to epileptiform activity. By conducting LFP recordings in acute brain slices from young male and female mice, we demonstrate that mutant animals exhibit significant changes in network excitability, reflected in increased Up state occurrence, decreased Up state duration and higher levels of extracellular spiking activity. Epileptiform activity was induced through two distinct and widely used in vitro protocols: the low magnesium and the 4‐Aminopyridine (4‐AP) model. In the former, slices from mutant animals manifested shorter latency for the expression of stable seizure‐like events. In contrast, when epilepsy was induced by 4‐AP, no significant differences were reported. We conclude that normal SST‐interneuron function has a significant role both in the regulation of the endogenous network activity, and in the transition to seizure‐like discharges in a context‐dependent manner.
Assessing the role of ultrasound for the evaluation of adult neck masses
Authors: Feier Joel , Self Quinn , Karabachev Alexander , Brundage William , Sajisevi Mirabelle 
Published: December 2022

AbstractObjectivesThe American Academy of Otolaryngology clinical practice guidelines recommend cross‐sectional imaging or fine needle aspiration for any neck mass in an adult that persists beyond 2 weeks that is not convincingly related to a bacterial infection. We aimed to assess the role of ultrasound in the evaluation and management of neck masses.MethodsA retrospective chart review was performed of adult patients evaluated in the Otolaryngology clinic at a single institution from December 2014 to December 2015 for a visible or palpable neck mass persistent beyond 2 weeks who had an ultrasound exam as part of their initial workup. Patients with a history of head and neck malignancy or those presenting wtih primary salivary or thyroid gland lesions were excluded. Sonographic features, demographics, imaging, and biopsy results were recorded.ResultsOf the 56 patients who met inclusion criteria, 36 (64.3%) received FNA or biopsy, of which 18 (50%) demonstrated malignant pathology. Twenty patients (35.7%) demonstrated benign features on ultrasound and did not undergo tissue sampling. Two of these 20 patients underwent subsequent cross‐sectional imaging. Eight of these 20 patients were followed with serial ultrasound with an average of 3 exams over 14.7 months. The remaining 12 patients had spontaneous resolution of their adenopathy. None of these 20 patients was subsequently diagnosed with malignancy.ConclusionIn this study, approximately one third of patients presenting with a visible or palpable neck mass were able to safely avoid cross‐sectional imaging and/or tissue sampling when ultrasound demonstrated features consistent with benign pathology. Our results suggest that ultrasound can play a useful role in the initial evaluation and management of adults presenting with a neck mass.Level of EvidenceIV.
Projective analytic vectors and infinitesimal generators
Authors: Cabral Rodrigo A. H. M. 
Published: December 2022

AbstractWe establish the notion of a “projective analytic vector”, whose defining requirements are weaker than the usual ones of an analytic vector, and use it to prove generation theorems for one‐parameter groups on locally convex spaces. More specifically, we give a characterization of the generators of strongly continuous one‐parameter groups which arise as the result of a projective limit procedure, in which the existence of a dense set of projective analytic vectors plays a central role. An application to strongly continuous Lie group representations on Banach spaces is given, with a focused analysis on concrete algebras of functions and of pseudodifferential operators.
Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism
Authors: Stefater‐Richards Margaret A. , Panciotti Courtney , Feldman Henry A. , Gourash William F. , Shirley Eleanor , Hutchinson John N. , Golick Lena , Park Sang W. , Courcoulas Anita P. , Stylopoulos Nicholas 
Published: December 2022

AbstractObjectiveRoux‐en‐Y gastric bypass surgery (RYGB) is among the most effective therapies for obesity and type 2 diabetes, and intestinal adaptation is a proposed mechanism for these effects. It was hypothesized that intestinal adaptation precedes and relates to metabolic improvement in humans after RYGB.MethodsThis was a prospective, longitudinal, first‐in‐human study of gene expression (GE) in the “Roux limb” (RL) collected surgically/endoscopically from 19 patients with and without diabetes. GE was determined by microarray across six postoperative months, including at an early postoperative (1 month ± 15 days) time point.ResultsRL GE demonstrated tissue remodeling and metabolic reprogramming, including increased glucose and amino acid use. RL GE signatures were established early, before maximal clinical response, and persisted. Distinct GE fingerprints predicted concurrent and future improvements in HbA1c and in weight. Human RL exhibited GE changes characterized by anabolic growth and shift in metabolic substrate use. Paradoxically, anabolic growth in RL appeared to contribute to the catabolic state elicited by RYGB.ConclusionsThese data support a role for a direct effect of intestinal energy metabolism to contribute to the beneficial clinical effects of RYGB, suggesting that related pathways might be potential targets of therapeutic interest for patients with obesity with or without type 2 diabetes.
Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling
Authors: Yeung Cindy H. T. , Beers Jessica L. , Jackson Klarissa D. , Edginton Andrea N. 
Published: December 2022

AbstractCannabidiol (CBD) is approved for treatment of seizures associated with two forms of epilepsy that become apparent in infancy or early childhood. To consider an adult physiologically‐based pharmacokinetic (PBPK) model for pediatric scaling, we assessed in vitro‐derived cytochrome P450 (CYP) and uridine 5′‐diphospho‐glucuronosyltransferase (UGT) enzyme contributions to CBD clearance in human. An i.v. PBPK model was constructed using CBD physicochemical properties and knowledge of disposition. The i.v. datasets were used for model building and evaluation. Oral PBPK models for CBD administered in fasted and fed states were developed using single dose oral datasets and parameters optimized from the i.v. model and evaluated with multiple dose datasets. Relative contributions of CBD metabolizing enzymes were partitioned according to in vitro studies. Clinical drug–drug interaction (DDI) studies were simulated using CBD fed state, itraconazole, fluconazole, and rifampicin PBPK models. Linear mixed effect modeling was used to estimate area under the concentration‐time curve from zero to infinity (AUC0–∞) perpetrator + CBD versus CBD alone. The i.v. and oral datasets used in model evaluation produced acceptable average fold error (AFE) of 1.28 and absolute AFE of 1.65. Relative contributions of drug‐metabolizing enzymes to CBD clearance were proposed from in vitro data: UGT1A7 4%, UGT1A9 16%, UGT2B7 10%, CYP3A4 38%, CYP2C19 21%, and CYP2C9 11%. The simulated DDI studies using the in vitro‐derived values produced AUC0–∞ treatment ratios comparable to observed: itraconazole 1.24 versus 1.07, fluconazole 1.45 versus 1.22, and rifampicin 0.49 versus 0.69. The constructed CBD PBPK models can predict adult exposures and have potential for use in pediatrics where exposure estimates are limited.