bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats
Authors: XI YUE , LI YONGXIA , REN WUJING , BO WENYAN , MA YIXUAN , PAN SHOU , GONG DA-WEI , TIAN ZHENJUN 
Published: March 2023

ABSTRACT

Purpose
The aim of this study was to investigate the function and mechanisms of ELABELA (ELA) in the aerobic exercise-induced antiapoptosis and angiogenesis of ischemic heart.

Methods
The myocardial infarction (MI) model of Sprague–Dawley rat was established by the ligation of the left anterior descending coronary artery. MI rats underwent 5 wk of Fc-ELA-21 subcutaneous injection and aerobic exercise training using a motorized rodent treadmill. Heart function was evaluated by hemodynamic measures. Cardiac pathological remodeling was evaluated by Masson’s staining and the calculation of left ventricular weight index. Cell proliferation, angiogenesis, and Yes-associated protein (YAP) translocation were observed by immunofluorescence staining. Cell apoptosis was analyzed by TUNEL. Cell culture and treatment were used to elucidate the molecular mechanism of ELA. Protein expression was detected by Western blotting. Angiogenesis was observed by tubule formation test. One-way or two-way ANOVA and Student’s t-test were used for statistical analysis.

Results
Aerobic exercise stimulated the endogenous ELA expression. Exercise and Fc-ELA-21 intervention significantly activated APJ-Akt-mTOR-P70S6K signaling pathway, kept more cardiomyocytes alive, and increased angiogenesis, so as to inhibit the cardiac pathological remodeling and improved the heart function of MI rats. Fc-ELA-32 also had the cellular and functional cardioprotective activities in vivo. In vitro, ELA-14 peptide regulated the phosphorylation and nucleoplasmic translocation of YAP and activated the APJ-Akt signaling pathway so as to increase the proliferation of H9C2 cells. Moreover, the antiapoptosis and the tubule formation of HUVECs were also enhanced by ELA-14, whereas the inhibition of Akt activity weakened such effects.

Conclusions
ELA is a potential therapeutic member that plays a key role through APJ-Akt/YAP signaling axis in aerobic exercise-induced cardioprotection of MI rats.
Hippocampal Subfield Volumes in Amateur Marathon Runners
Authors: AO YA-WEN , LI YU-SHUANG , ZHAO YI-LIN , ZHANG LIANG , YANG REN-JIE , ZHA YUN-FEI 
Published: March 2023

ABSTRACT

Purpose
Numerous studies have implicated the involvement of structure and function of the hippocampus in physical exercise, and the larger hippocampal volume is one of the relevant benefits reported in exercise. It remains to be determined how the different subfields of hippocampus respond to physical exercise.

Methods
A 3D T1-weighted magnetic resonance imaging was acquired in 73 amateur marathon runners (AMR) and 52 healthy controls (HC) matched with age, sex, and education. The Montreal Cognitive Assessment, the Pittsburgh Sleep Quality Index (PSQI), and the Fatigue Severity Scale were assessed in all participants. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the two groups and ascertained correlation between the significant subfield metrics and the significant behavioral measure in AMR group.

Results
The AMR had significantly better sleep than HC, manifested as with lower score of PSQI. Sleep duration in AMR and HC was not significantly different from each other. In the AMR group, the left and right hippocampus, cornu ammonis 1 (CA1), CA4, granule cell and molecular layers of the dentate gyrus, molecular layer, left CA2–3, and left hippocampal–amygdaloid transition area volumes were significantly larger compared with those in the HC group. In AMR group, the correlations between the PSQI and the hippocampal subfield volumes were not significant. No correlations were found between hippocampal subfield volumes and sleep duration in AMR group.

Conclusions
We reported larger volumes of specific hippocampal subfields in AMR, which may provide a hippocampal volumetric reserve that protects against age-related hippocampal deterioration. These findings should be further investigated in longitudinal studies.
Bioactive phytoconstituents and hemostatic and angiogenetic activities of Chromolaena odorata L. leaf extract gel on an animal epistaxis model
Authors: Husni T. R. Teuku , Darmawi Darmawi , Azwar Azwar , Jamil Kurnia Fitri 
Published: March 2023

Introduction: Epistaxis occurs in approximately 60% of the general population globally and herbal medicine for its treatment including Chromolaena odorata L. could be one of the alternatives. The aims of this study were: (a) to determine the putative compounds and the bioactivities of C. odorata leaf extract; and (b) to assess their hemostatic and angiogenesis properties in an animal epistaxis model. Methods: The putative compounds of C. odorata extract were determined using gas chromatography and mass spectroscopy (GC-MS) and the bioactivities were determined using the Molinspiration Cheminformatics 2018 software. The hemostatic and angiogenesis activities were assessed using an epistaxis model of male rabbits (Oryctolagus cuniculus), on which three concentrations of C. odorata were tested. The gel was applied twice a day until 21 days. The hemostatic activity was evaluated by measuring the clotting time and the angiogenesis activity was evaluated by measuring the serum blood electrolyte, serum CD34 and CD68 levels and the histopathology of fibroblast and new blood vessels. Results: Eight putative compounds with activities that increased immune responses and angiogenesis by having antithrombotic, antioxidant and anti-inflammatory effects were identified. Those compounds had a range of bioactivity to G-protein coupled receptor ligand, ion channel modulator, kinase inhibitor, nuclear receptor ligand, protease inhibitor and enzyme inhibitor. Our data suggested that C. odorata extract had an effect on the levels of sodium, potassium and chloride. There was no significant difference in the mean levels of CD34 and CD68 among treatment and control groups, p=0.443 and p>0.050, respectively. The extract had no significant effect in inducing the growth of fibroblasts. Our data indicated that C. odorata extract induced angiogenesis significantly (p=0.018). Conclusions: The C. odorata extract gel consisted of the compounds that contribute in antithrombotic, antioxidant and anti-inflammatory activities and these compounds increased the angiogenesis during wound healing in the epistaxis model.
scANANSE gene regulatory network and motif analysis of single-cell clusters
Authors: Smits Jos G.A. , Arts Julian A. , Frölich Siebren , Snabel Rebecca R. , Heuts Branco M.H. , Martens Joost H.A. , van Heeringen Simon J. , Zhou Huiqing 
Published: March 2023

The recent development of single-cell techniques is essential to unravel complex biological systems. By measuring the transcriptome and the accessible genome on a single-cell level, cellular heterogeneity in a biological environment can be deciphered. Transcription factors act as key regulators activating and repressing downstream target genes, and together they constitute gene regulatory networks that govern cell morphology and identity. Dissecting these gene regulatory networks is crucial for understanding molecular mechanisms and disease, especially within highly complex biological systems. The gene regulatory network analysis software ANANSE and the motif enrichment software GimmeMotifs were both developed to analyse bulk datasets. We developed scANANSE, a software pipeline for gene regulatory network analysis and motif enrichment using single-cell RNA and ATAC datasets. The scANANSE pipeline can be run from either R or Python. First, it exports data from standard single-cell objects. Next, it automatically runs multiple comparisons of cell cluster data. Finally, it imports the results back to the single-cell object, where the result can be further visualised, integrated, and interpreted. Here, we demonstrate our scANANSE pipeline on a publicly available PBMC multi-omics dataset. It identifies well-known cell type-specific hematopoietic factors. Importantly, we also demonstrated that scANANSE combined with GimmeMotifs is able to predict transcription factors with both activating and repressing roles in gene regulation.
"SOVEREIGNTY" AS A MEDIA COGNITIVE CATEGORY OF MODERN POLITICAL DISCOURSE
Authors: Golikova T. 
Published: March 2023

Introduction. The article is devoted to the research of the media cognitive category "sovereignty" in the modern political discourse. The political narratives were the study material. They were taken in the amount of 980 documents from the official online newspaper Kommersant of 2021-2022.
The aim of the article is linguistic and discourse modeling of the media cognitive category "sovereignty" in the modern political discourse.
Methodology and research methods. Adhering to the traditional three-term division into discursive, communicative and lexico-grammatical levels of description for communication science, we present the communicative-discursive model “sovereignty” based on the materials of the official Russian media in 2021–2022. The article uses the research methods of linguoconceptology, linguoculturology, such as modeling concepts, methods of component lexical analysis that help to establish the seme composition of individual lexemes; and there is also lexicographic analysis.
Results. According to the analysis, the media cognitive category "sovereignty" is represented as a multicomponent structure consisting of a certain set of elements, parts, components, although the full structure is not declared or described. This leads to the conclusion about inaccurate, deliberately distorted modeling from the media. The article shows that modern political discourse provides a field for information war and models the category "sovereignty" haphazardly, non-terminologically, replacing and obscuring the meanings of the power, state, nation, people, private industries and human livelihood. Metaphorically, the political category "sovereignty" in the official media names and tries to explain the most complex phenomena of our modern world, but it does it with a great deal of uncertainty and vagueness, maximally generalizing and masking the meanings necessary for public consciousness in order to manipulate in the information war. “Sovereignty” seems to be a kind of participant in “combat” operations of this war, it takes a certain side and has enemies and allies, it is attacked, but it, in turn, defends itself, needs protection and support. The category "sovereignty" as a tool of manipulation dictates, directs perception, makes perceive current events in a distorted way, serves as a manipulative scale of evaluation and value.
The scientific novelty of the study lies in the systematization of various aspects of the representation of the sovereignty category as a fragment of the world's political picture.
The practical significance of the study lies in the use of modeling methods for various text-discursive fragments in the communicative and linguo-discursive aspects, which is aimed at clarifying existing models and constructing and interpreting the latest ones.
Communication Vector of Public Art. Global Scale in Regional Locus
Authors: Karceva E. , Shlykova O. 
Published: March 2023

This paper examines the dynamics of public art in Russia, explores specific features of the phenomenon that distinguish it from other new art forms and genres. The authors focus on the historical and cultural aspects of the interaction between Russian artists and urban space, their fruitful communication strategies and successful projects of service, art, PR communications reflecting the communicative behaviour of the artist-viewer-power in the modern information-saturated urban environment of Russia, new turns of instrumental development of territories, conceptual shifts of public art caused by including the impact of digital transformations on the culture of the city.
A review of various foreign and domestic studies provides a retrospective look at the interpretation of public art as a creative process, a system of communicative interaction and changes in urban space, and, at the same time, the harmonization of the environment and the person, creative understanding of the involvement of the individual to his place of residence with its cultural codes and meanings.
This paper will broadly trace the evolution of public art in Russia and its current scope that was enhanced by the sharp increase of the curatorial projects that deal with public art.
On the one hand, the demand for public art in Russia is exacerbated by the growing number of curatorial projects aimed at working with space and environment in the context of the festival and biennial movement and art residencies, and on the other hand, the increased interest of the municipal and government officials in public art as a driving force for territory and urban development.
The article provides a comparative analysis of successfully implemented projects in various regions of Russia, which gave a new impetus to the development of public art, bringing the space closer to the population, expanding the communicative capabilities of a smart city and its creative resident.
The Specificity of Intertextuality as a Risk Factor of a Communication Failure (on the Example of the Modern German Internet Poetry Discourse)
Authors: Dacko D. 
Published: March 2023

The article considers the phenomenon of intertextuality as a textual category. The non-recognition of intertextuality can lead to communication failure in dialogic, when the recipient attempts to enter the communicative intention of the sender, as well as at the time of reading, when the recipient is decoding and analyzing the information received. The relevance of the research is determined by the importance of the more detailed study of such means of explication of intertextual connections as allusion and precedent phenomena within the modern German poetry Internet discourse.
The aim of research is to identify the means of intertextuality actualization, that are the causes of communication failure in the interpretation of the modern German texts.
Methodology and research methods. The research work used methods of systematization and generalization of the scientific material, a descriptive-analytical method, the method of lingual-stylistic analysis of the text.
Results. The article focuses on the polyphony of the German poetry texts, that is expressed in the incorporation of literary and cultural-specific codes. Precedent phenomena and allusions are the sources of communication failures in German poetry discourse and they serve as preferential ways of building intertextual connections in German poems. The author recommends to increase the levels of linguistic and general cultural competence in order to minimize the communicative dissonance, that is a result of the non-recognition of intertextuality.
Scientific novelty lies in the study of the specifics of communication failures on the example of modern German poetry discourse.
The practical significance is determined by the possibility of using the obtained scientific results in special university basic courses on translation theory, cognitive linguistics, stylistics and culture of speech, linguo-stylistic interpretation of the text.
POLITENESS AND ANTIPOLITENESS IN THE COMMUNICATION SPACE OF THE INTERNET (A STUDY OF THE ONLINE COMMENTS)
Authors: Van Yue 
Published: March 2023

This article focuses on the concepts of politeness and antipoliteness and their manifestation in online comments.
The aim of the article is to describe the concepts of "politeness" and "antipoliteness" as semantic phenomena consisting of a set of speech genres manifested in Internet communication.
The semantic fields of politeness and antipoliteness are revealed, and a distinction is made between antipoliteness, rudeness and impoliteness.
The paper analyses examples of politeness as ameliorative behaviour and impoliteness as pejorative behaviour. These behavioural manifestations are illustrated using examples of online comments (400 comments published on various Internet platforms served as the material for the study).
A scheme illustrating the attribution of speech intentions defining a speech genre to polite or antipolite behaviour is proposed.
Dropping Anchor: A Field Experiment Assessing a Salary History Ban with Archival Replication
Authors: Sherman Eliot L. , Brands Raina , Ku Gillian 
Published: March 2023

Could a salary history ban (SHB) reduce the gender wage gap? Proponents of this intervention believe the gap is sustained by the practice of eliciting salary histories from job applicants. Although observational studies suggest that SHB operates as envisioned, two features complicate the interpretation of its effects. These are, respectively, the passage of relevant legislation alongside SHB, and the presence of public campaigns that propel SHB into law. We assessed SHB in the United Kingdom, where neither potential confound was present, and did not find evidence that the intervention operated as intended. An intention-to-treat analysis of a 16-month field experiment, conducted with 230 staff hires at a private educational institution, indicates that SHB was about as likely to harm new hires as it was to help them. Additional analyses did not reveal significant differences between women and men. We supplement these results with an interrupted time series analysis of 3,687 placements made by a recruitment firm that voluntarily adopted SHB for its job candidates. Salaries were significantly lower under SHB, but were not significantly different for women versus men. Taken together, our results suggest that SHB was ineffective in isolation from contemporaneous legislative changes, proequality messaging, or some combination thereof. This paper was accepted by Olav Sorenson, organizations. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4658 .
Vehicle Rebalancing in a Shared Micromobility System with Rider Crowdsourcing
Authors: Jin Ziliang , Wang Yulan , Lim Yun Fong , Pan Kai , Shen Zuo-Jun Max 
Published: March 2023

Problem definition: Shared micromobility vehicles provide an eco-friendly form of short-distance travel within an urban area. Because customers pick up and drop off vehicles in any service region at any time, such convenience often leads to a severe imbalance between vehicle supply and demand in different service regions. To overcome this, a micromobility operator can crowdsource individual riders with reward incentives in addition to engaging a third-party logistics provider (3PL) to relocate the vehicles. Methodology/results: We construct a time-space network with multiple service regions and formulate a two-stage stochastic mixed-integer program considering uncertain customer demands. In the first stage, the operator decides the initial vehicle allocation for the regions, whereas in the second stage, the operator determines subsequent vehicle relocation across the regions over an operational horizon. We develop an efficient solution approach that incorporates scenario-based and time-based decomposition techniques. Our approach outperforms a commercial solver in solution quality and computational time for solving large-scale problem instances based on real data. Managerial implications: The budgets for acquiring vehicles and for rider crowdsourcing significantly impact the vehicle initial allocation and subsequent relocation. Introducing rider crowdsourcing in addition to the 3PL can significantly increase profit, reduce demand loss, and improve the vehicle utilization rate of the system without affecting any existing commitment with the 3PL. The 3PL is more efficient for mass relocation than rider crowdsourcing, whereas the latter is more efficient in handling sporadic relocation needs. To serve a region, the 3PL often relocates vehicles in batches from faraway, low-demand regions around peak hours of a day, whereas rider crowdsourcing relocates a few vehicles each time from neighboring regions throughout the day. Furthermore, rider crowdsourcing relocates more vehicles under a unimodal customer arrival pattern than a bimodal pattern, whereas the reverse holds for the 3PL. Funding: This work was supported by the Research Grants Council of Hong Kong [Grants 15501319 and 15505318] and the National Natural Science Foundation of China [Grant 71931009]. Z. Jin was supported by the Hong Kong PhD Fellowship Scheme. Y. F. Lim was supported by the Lee Kong Chian School of Business, Singapore Management University [Maritime and Port Authority Research Fellowship]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.1199 .
Job satisfaction among general radiographers and assistant practitioners: a mixed-methods survey
Authors: Milner Robert , Akhtar Miriam 
Published: March 2023

Background/Aims Maintaining staff satisfaction is a major ambition for healthcare leaders worldwide, as it is directly linked with patient outcomes. Despite this, there is a dearth of literature on the job satisfaction of radiographers. This study aimed to explore the job satisfaction and role perceptions of radiographers and assistant practitioners at a local district general hospital. Methods All radiographers and assistant practitioners (n=39) working in the general X-ray department of a small-medium sized NHS trust were invited to complete either an online or physical copy of a semi-structured, mixed-methods questionnaire regarding their job satisfaction and perceptions of their role. Items included quantitative (multiple choice) and qualitative (free-text) questions. Quantitative data were analysed using descriptive statistics while qualitative data were analysed using content analysis. Results A total of 21 individuals completed the questionnaire, giving a 53.8% response rate. The mean score for happiness in their current role was fairly high at 7.3/10, but staff with more experience had lower average happiness scores relating to their role and working hours. Respondents were confident working in most clinical areas, including mobile units, but lacked confidence working in computed tomography and fluoroscopy. Conclusions Strategies are needed to understand and address issues that may be causing more experienced radiography staff to experience less happiness in their job role. Lack of experience in computed tomography and fluoroscopy also needs to be addressed, possibly by ensuring that radiography staff regularly work in these areas to build their confidence.
Introducción
Authors: Polanco Martínez Fernando 
Published: March 2023

La Lingüística Cognitiva (LC, en adelante) se ha convertido, en los últimos tiempos, en uno de los paradigmas teóricos más sugestivos –y cada vez más influyentes– en el estudio de las lenguas naturales. Se trata, más que de una teoría del lenguaje, de una estrategia, de una perspectiva integradora que engloba diversos acercamientos al estudio lingüístico. Constituye, en definitiva, un enfoque teórico flexible (Geeraerts y Cuickens 2007: 4)1 en el que confluyen diferentes acercamientos al análisis lingüístico con una visión común del lenguaje y de su estudio.