bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography–mass spectrometry (LC-MS/MS)
Authors: Pei Jian , Li Pei , Gao Yun H. , Tian Bao G. , Wang Da Y. , Zheng Yu , Liu Li Y. , Zhang Zhi Y. , Huang Si S. , Wen Min , Xu Xiang , Xia Lei 
Published: February 2023

Abstract
Purpose
Brain invasion in meningiomas is considered an indicator of more aggressive behavior and worse prognosis. But the precise definition and the prognostic role of brain invasion remains unsolved duo to lacking a standardized workflow of surgical sampling and the histopathological detection. Searching for molecular biomarker expression correlating with brain invasion, could contribute to establish a molecular pathological diagnosis without problems of subjective interobserver variation and deeply understand the mechanism of brain invasion and develop innovative therapeutic strategies.

Methods
We utilized liquid chromatography tandem mass spectrometry to quantify protein abundances between non-invasive meningiomas (n = 21) and brain-invasive meningiomas (n = 21) spanning World Health Organization grades I and III. After proteomic discrepancies were analyzed, the 14 most up-regulated or down-regulated proteins were recorded. Immunohistochemical staining for glial fibrillary acidic protein and most likely brain invasion-related proteins was performed in both groups.

Results
A total of 6498 unique proteins were identified in non-invasive and brain-invasive meningiomas. Canstatin expression in the non-invasive group was 2.1-fold that of the brain-invasive group. The immunohistochemical staining showed canstatin expressed in both groups, and the non-invasive group showed stronger staining for canstatin in the tumor mass (p = 0.0132) than the brain-invasive group, which showed moderate intensity.

Conclusion
This study demonstrated the low expression of canstatin in meningiomas with brain invasion, a finding that provide a basis for understanding the mechanism of brain invasion of meningiomas and may contribute to establish molecular pathological diagnosis and identify novel therapeutic targets for personalized care.
Landslide susceptibility mapping using maximum entropy (MaxEnt) and geographically weighted logistic regression (GWLR) models in the Río Aguas catchment (Almería, SE Spain)
Authors: Boussouf S. , Fernández T. , Hart A. B. 
Published: February 2023

AbstractA landslide susceptibility analysis has been made in the Río Aguas catchment (Almeria, Southeast Spain), using two statistical models, Maximum Entropy (MaxEnt) and Geographically Weighted Logistic Regression (GWLR). For this purpose, a previous landslide inventory has been used and re-elaborated, reaching a total incidence of 2.58% of the whole area. Different types of movements have been distinguished, being rock falls, slides and complex movements the predominant. From the inventory, the centroid of the rupture zone has been extracted to represent the landslides introduced in the models. A previous factor analysis has been made, using 12 predictors related to morphometry, hydrography, geology and land cover, with 5 m grid spacing, allowing the selection of factors to be used in the analysis and discarding those showing correlation between them. Then, MaxEnt and GWLR models are applied using different distributions of training and testing samples from the landslide inventory. For the validation, the Area Under the Curve of the Receiver Operating Characteristic (AUC-ROC) has been used but additionally, the degree of fit (DF) has allowed to validate the rupture zones themselves, not only the centroids. Results show an excellent prediction with both metrics in all the methods and samples, but the better results are obtained in the GWLR method for AUC and in the MaxEnt for the degree of fit. Therefore, a consensus model of both methods has been obtained, that improves even more the results reaching an AUC value of 0.99 and a degree of fit of 90%.
Analysis of Galactic Cosmic Ray Anisotropy During the Time Period from 1996 to 2020
Authors: Wozniak Witold , Iskra Krzysztof , Modzelewska Renata , Siluszyk Marek 
Published: February 2023

AbstractWe study the influence of drift effects on the galactic cosmic ray anisotropy (GCRA) in different periods of solar activity (from 1996 to 2020) using data from the global network of neutron monitors. We analyze the GCRA in 1996, the last year of Solar Cycle 22 with positive polarity ($A>0$
A
>
0
), Solar Cycles 23 and 24 with both positive ($A>0$
A
>
0
) and negative polarities ($A<0$
A
<
0
), and the 2020 onset of Solar Cycle 25 with positive polarity ($A>0$
A
>
0
). We show that in positive polarity periods, a diffusion model with noticeably manifested drift is acceptable, whereas the diffusion-dominated model of galactic cosmic ray (GCR) transport is more acceptable in negative polarity periods.We found that the average radial component of the drift vector for $A>0$
A
>
0
practically points to 12 h, and for the $A<0$
A
<
0
polarity to 24 h, respectively. These results are consistent with the drift theory of modulation of GCRs. According to theory, during positive or negative polarity periods, a drift stream of GCRs is directed away from or toward the Sun, respectively, thus giving rise to long-term changes of the radial component of the GCRA.The calculated magnitudes of the radial and tangential components of the GCRA in different sectors of the heliospheric magnetic field were used to calculate the parameters that characterize the GCR modulation in interplanetary space.
Entrepreneurial experimentation in business model dynamics: Current understanding and future opportunities
Authors: Sanasi Silvia 
Published: February 2023

Abstract
The concept of business model dynamics has been gaining momentum in the academic literature to refer to all the alterations in a firm’s business model. This study taps into the shift from the traditional ontological view of business models as the static implementation of a firm’s strategy, toward a phenomenological stance that portrays the business model as a unit of analysis for different phenomena related to it. Building on this emerging discourse, this review offers an interpretive lens on the role of entrepreneurial experimentation in business model dynamics, namely business model innovation, validation, scaling, and pivots. This study proposes a unified framework for understanding these phenomena, discusses the research gaps emerging from this perspective, and advances a set of open research avenues to inform future research. The study also taps into the recent managerial interest in methods involving experimentation, such as the Lean Startup method.
The Idea of Merit: Delineation and Challenges
Authors: Clavero García Sergio R. 
Published: February 2023

AbstractThe idea of merit is at the core of intense contemporary debate related to social justice in general and meritocracy in particular. In this paper, I aim to differentiate the notion of merit from two other notions with which it is often mistakenly identified, namely the concepts of talent and achievement. Here, I define “merit” as the value of an action that 1) is imputable to a subject‘s free conduct, 2) implies some sort of effort, and 3) is oriented towards a good. Merit so understood is a valuable phenomenon considered from various perspectives, and therefore the subject who has it deserves to be properly recognized. But, more importantly, this merit is valuable in a sense that is different from the value attached to talent and achievement. We should therefore try to recognize the three of them according to their specificity. I conclude by signaling some problems and limitations associated with the idea of merit that, on the one hand, contribute to the aforementioned confusion and, on the other hand, show that the principle of merit must not be absolutized to the detriment of other forms of value (including talent and achievement).
Necessary condition analysis (NCA): review of research topics and guidelines for good practice
Authors: Dul Jan , Hauff Sven , Bouncken Ricarda B. 
Published: February 2023

AbstractNecessary condition analysis (NCA) is an increasingly used or suggested method in many business and management disciplines including, for example, entrepreneurship, human resource management, international business, marketing, operations, public and nonprofit management, strategic management, and tourism. In the light of this development, our work delivers a review of the topics analyzed with NCA or in which NCA is proposed as a method. The review highlights the tremendous possibilities of using NCA, which hopefully encourages other researchers to try the method. To support researchers in future NCA studies, this article also provides detailed guidelines about how to best use NCA. These cover eight topics: theoretical justification, meaningful data, scatter plot, ceiling line, effect size, statistical test, bottleneck analysis, and further descriptions of NCA.
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study
Authors: in ‘t Veld Aliede E. , Grievink Hendrika W. , van der Plas Johan L. , Eveleens Maarse Boukje C. , van Kraaij Sebastiaan J. W. , Woutman Tess D. , Schoonakker Mascha , Klarenbeek Naomi B. , de Kam Marieke L. , Kamerling Ingrid M. C. , Jansen Manon A. A. , Moerland Matthijs 
Published: February 2023

AbstractBased on its wide range of immunosuppressive properties, hydroxychloroquine (HCQ) is used for the treatment of several autoimmune diseases. Limited literature is available on the relationship between HCQ concentration and its immunosuppressive effect. To gain insight in this relationship, we performed in vitro experiments in human PBMCs and explored the effect of HCQ on T and B cell proliferation and Toll-like receptor (TLR)3/TLR7/TLR9/RIG-I-induced cytokine production. In a placebo-controlled clinical study, these same endpoints were evaluated in healthy volunteers that were treated with a cumulative dose of 2400 mg HCQ over 5 days. In vitro, HCQ inhibited TLR responses with IC50s > 100 ng/mL and reaching 100% inhibition. In the clinical study, maximal HCQ plasma concentrations ranged from 75 to 200 ng/mL. No ex vivo HCQ effects were found on RIG-I-mediated cytokine release, but there was significant suppression of TLR7 responses and mild suppression of TLR3 and TLR9 responses. Moreover, HCQ treatment did not affect B cell and T cell proliferation. These investigations show that HCQ has clear immunosuppressive effects on human PBMCs, but the effective concentrations exceed the circulating HCQ concentrations under conventional clinical use. Of note, based on HCQ’s physicochemical properties, tissue drug concentrations may be higher, potentially resulting in significant local immunosuppression. This trial is registered in the International Clinical Trials Registry Platform (ICTRP) under study number NL8726.
Analysis of surgical quality indicators after certification as a Hernia Center
Authors: Willms Arnulf Gregor , Schaaf Sebastian , Schwab Robert 
Published: February 2023

AbstractCertifications are an increasingly used tool of quality management in the health care system. The primary goal is to improve the quality of treatment due to implemented measures based on a defined catalog of criteria and standardization of the treatment processes. However, the extent to which this affects medical and health-economic indicators is unknown. Therefore, the study aims to examine the possible effects of the certification as a Reference Center for Hernia Surgery on the treatment quality and reimbursement dimensions. The observation and recording periods were defined as 3 years before (2013–2015) and 3 years after certification as a "Reference Center for Hernia Surgery" (2016–2018). Possible changes due to the certification were examined based on multidimensional data collection and analysis. In addition, the aspects of structure, process and result quality, and the reimbursement situation were reported. One thousand three hundred and nineteen cases before and one thousand four hundred and three cases after certification were included. After the certification, the patients were older (58.1 ± 16.1 vs. 64.0 ± 16.1 years, p < 0.01), had a higher CMI (1.01 vs. 1.06), and a higher ASA score (< III 86.9 vs. 85.5%, p < 0.01). The interventions became more complex (e.g., recurrent incisional hernias 0.5% vs. 1.9%, p < 0.01). The mean length of hospital stay was significantly reduced for incisional hernias (8.8 ± 5.8 vs. 6.7 ± 4.1 days, p < 0.001). The reoperation rate for incisional hernias also decreased significantly from 8.24 to 3.66% (p = 0.04). The postoperative complication rate for inguinal hernias was significantly reduced (3.1 vs. 1.1%, p = 0.002). The reimbursement of the hernia center increased by 27.6%. There were positive changes in process and outcome quality and reimbursement after the certification, which supports the effectivity of certifications in hernia surgery.
Sensitivity-Enhanced Hot-Wire Anemometer by Using Cladding-Etched Fiber Bragg Grating
Authors: Tang Yuhan , Chen Xuke , Zhang Jiarui , Lv Dajuan , Xiong Liangming , Dong Xinyong 
Published: February 2023

AbstractA sensitivity-enhanced hot-wire anemometer based on a cladding-etched optical fiber Bragg grating (FBG) coated with a layer of silver film and optically heated by using a 1480 nm laser diode is demonstrated. The silver film absorbs the laser power to heat the FBG to a certain high temperature and the airflow cools down the FBG hot-wire with the cooling effect and hence the Bragg wavelength of the FBG is determined by the airflow velocity. Experimental measurement results show that the heating efficiency of the FBG hot wire is improved by 3.8 times in magnitude by etching the fiber cladding from 125 µm down to 73.4 µm, and the achieved airflow velocity sensitivities, under a laser power of 200 mW, are −3 180 pm/(m/s), −889 pm/(m/s), −268 pm/(m/s), and −8.7 pm/(m/s) at different airflow velocities of 0.1 m/s, 0.5 m/s, 1.5 m/s, and 17 m/s, respectively. In comparison, the sensitivities are only −2193 pm/(m/s), −567 pm/(m/s), −161 pm/(m/s), and −4.9 pm/(m/s) for the reference anemometer without cladding etching even at a much higher heating laser power of 530 mW. These results prove that the method by using a cladding-etched FBG to improve sensitivity of FBG-based hot-wire anemometers works and the sensitivity is improved significantly.
On monotone pseudocontractive operators and Krasnoselskij iterations in an ordered Hilbert space
Authors: Jorquera Álvarez Eduardo Daniel 
Published: February 2023

AbstractThe aim of this work is to establish fixed point results in ordered Hilbert spaces for monotone operators with a pseudocontractive property. We state monotone versions of Theorem 12 in [F. E. Browder, W. V. Petryshyn, Construction of fixed points of nonlinear mappings in Hilbert space, J. Math. Anal. Appl. 20 (1967), 197–228] and Theorem 2.1 in [Berinde, Vasile. Weak and strong convergence theorems for the Krasnoselskij iterative algorithm in the class of enriched strictly pseudocontractive operators, Annals of West University of Timisoara-Mathematics and Computer Science, vol. 56, no. 2, 2018, pp. 13–27], as well as, several related results. Further results, in Hilbert spaces without a partial order, are stated too.
Tensile Deformation of B19′ Martensite in Nanocrystalline NiTi Wires
Authors: Šittner P. , Molnárová O. , Bian X. , Heller L. , Seiner H. 
Published: February 2023

AbstractDeformation mechanisms activated during tensile deformation of nanocrystalline NiTi wire in martensite state were investigated by combination of two experimental methods: (i) analysis of the evolution of martensite-variant microstructures in grains of deformed wire by TEM and (ii) analysis of the evolution of martensite texture by in situ synchrotron X-ray diffraction. The obtained results are linked to the activity of various twinning processes in martensite. It is concluded that martensite reorientation proceeds via motion of interdomain interfaces, gives rise to reoriented martensite with microstructure consisting of single (001) compound-twinned domain in each grain and results in sharp two-fiber texture of the martensite. The reorientation process leaves behind only very small unrecovered strains and very few dislocation defects in the austenitic microstructure of the deformed wire after unloading and heating. Plastic deformation of B19′ martensite proceeds via peculiar deformation mechanism which combines (100) deformation twinning with [100]/(011) dislocation slip based kinking. It gives rise to very special martensite variant microstructures consisting of deformation twin bands and kink bands containing martensite lattice aligned with [010] direction and characteristic two-fiber martensite texture. Reverse martensitic transformation of plastically deformed martensite upon unloading and heating leaves behind large unrecovered strains and high density of lattice defects in austenite. But there are also significant recoverable strains up to 10%. While the martensite matrix in grains of plastically deformed wire transforms into parent austenite matrix, (20-1) deformation twins transform into {114} austenite twins.
Centrality measure and visualization technique for multiple-parent nodes of earthquakes based on correlation-metric
Authors: Yamagishi Yuki , Saito Kazumi , Hirahara Kazuro , Ueda Naonori 
Published: February 2023

AbstractIn this paper, we address the problem of earthquake declustering, and propose ak-nearest neighbors approach based on the selection of multiple-parent nodes with respect to each of the given earthquakes, which can be regarded as a natural extension of the conventional correlation-metric method based on the selection of a single-parent node. Based on this approach, we develop a centrality measure that exploits link weight assigned by a logarithmic-distance scheme and a technique of individually visualizing each set of child nodes with respect to given target earthquakes. For experimental evaluation, we used an earthquake catalog covering Japan and selected 24 earthquakes that caused considerable damage or casualties. We first show that our proposed centrality measure using a logarithmic-distance scheme can rank these 24 major earthquakes higher than four link-weighting schemes (i.e., uniform, magnitude, inverse-distance, and normalized-inverse-distance weighting) and conventional single-parent selection. We then show that unlike the conventional approach to simultaneously visualizing all the events in the catalog, our proposed technique can produce a naturally interpretable classification result for these 24 major earthquakes, by individually visualizing each set of the first tok-th child nodes with different colored markers plotted in the directly interpretable spatio and temporal metrics. As a consequence, we confirm that our approach based on multiple-parent selection is vital and promising.
Age of First Overweight and Obesity, COVID-19 and Long COVID in Two British Birth Cohorts
Authors: Bridger Staatz Charis , Bann David , Ploubidis George B. , Goodman Alissa , Silverwood Richard J. 
Published: February 2023

AbstractLonger exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25 kg/m2) and obese (> 30 kg/m2). Logistic regression was used to assess associations with COVID-19 (self-reported and serology-confirmed), severity (hospital admission and contact with health services) and long-COVID reported at ages 62 (NCDS) and 50 (BCS70). An earlier age of obesity and overweight, compared to those who never became obese or overweight, was associated with increased odds of adverse COVID-19 outcomes, but results were mixed and often underpowered. Those with early exposure to obesity were over twice as likely in NCDS (odds ratio (OR) 2.15, 95% confidence interval (CI) 1.17–4.00) and three times as likely in BCS70 (OR 3.01, 95% CI 1.74–5.22) to have long COVID. In NCDS they were also over four times as likely to be admitted to hospital (OR 4.69, 95% CI 1.64–13.39). Most associations were somewhat explained by contemporaneous BMI or reported health, diabetes or hypertension; however, the association with hospital admission in NCDS remained. An earlier age of obesity onset is related to COVID-19 outcomes in later life, providing evidence of the long-term impact of raised BMI on infectious disease outcomes in midlife.
Improvements in the performance of a three
element high lift system by the application of
airjet vortex generators
Authors: Innes F. , Pearcey H. H. , Sykes D. M. 
Published: February 2023

SummaryWindtunnel tests on a two-dimensional model of a three
element high lift system in a takeoff mode indicate
that airjet vortex generators can produce a
significant increase in lift at a given angle of
incidence and a substantial increase in
CLmax. An associated
reduction in profile drag is inferred from
measurements of momentum defect on the upper
surface.The improvements are much greater than those typically
achieved with vane vortex generators and cannot
simply be associated with the suppression of
boundary layer separation. Instead, the airjets and
the vortices which they generate promote enhanced
mixing and momentum transfer across the complex
shear layers above the main wing, from the external
flow right through to the surface. Detailed surveys
reveal, for example, that the slat wake is dispersed
— or absorbed into a region of greater shear — and
that the growth of the main wing boundary layer is
significantly reduced.It is suggested that neither the relatively low
Reynolds numbers . and Mach numbers of the tests,
nor the effects of windtunnel interference, detract
from the general relevance of the novel principle
involved. Attention is drawn, however, to the need
for further work to elucidate and quantify the flow
mechanisms and to establish the balance between the
benefits from the improved aerodynamics and the
performance costs of installing and supplying the
jets.
Two-dimensional viscous flow past flexible
sail sections close to ideal
incidence
Authors: Jackson P. S. , Fiddes S. P. 
Published: February 2023

AbstractA model of the viscous flow past a flexible sail
section operating near the ideal incidence is
described. Viscous effects are calculated via weak
viscous-inviscid interaction of a panel method and
an integral boundary layer method, and a new model
for the leading edge separation bubble is
introduced. The flexible section is allowed to
deform in response to the pressure and shear
stresses acting on it. Results are presented for the
effect of incidence, excess length and Reynolds
number on the development of the boundary layers on
each side of the section and the consequences for
the lift and drag of the section are described. The
numerical model is compared with experimental
results, giving in general good agreement and
shedding light on the physics of the viscous flow
past flexible membranes.