bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thick‐Network Electrode: Enabling Dual Working Voltage Plateaus of Zn‐ion Micro‐Battery with Ultrahigh Areal Capacity
Authors: Wu Yudong , He Ningning , Liang Guojin , Zhang Chaofeng , Liang Changhao , Ho Derek , Wu Mingzai , Hu Haibo 
Published: June 2023

AbstractAqueous Zn‐ion micro‐batteries (AZMBs) have been recently shown to be promising integrated and safe micropower sources for portable electronics but with wide commercial adoption greatly constrained by their relatively low areal capacity. Although increasing the electrode thickness is proposed, the performance is compromised due to sluggish reaction kinetics, slow ion diffusion rate, and underutilization of active materials. Herein, the technique of utilizing a 3D thick‐network electrode, consisting of closely interweaved MnO2 nanowires (MnO2 NWs), silver nanowires (AgNWs), and carbon nanotubes (CNTs) is presented. The technique readily enables electrode realization up to a thickness of 351 µm, where the porous structure, high hydrophilicity, and fast electrolyte infiltration jointly contribute to fast kinetics. Matching with a Zn metal anode, the prototyped AZMBs acquire an ultra‐high areal capacity/power density of 809 µAh cm−2/1951 µW cm−2. Additionally, as MnO2 NWs and AgNWs collectively participate in the reaction as active substances, the AZMBs deliver dual voltage plateaus to further improve the areal energy density, realizing a maximum value of 896 µWh cm−2. The 3D thick‐network electrode supporting dual working voltage plateaus can provide a path forward for developing AZMBs with simultaneously ultra‐high areal capacity and energy density.
A Dual Heat Shock Protein Down‐Regulation Strategy Using PDA/Cu/ICG/R Controlled by NIR “Switch” Enhances Mild‐Photothermal Therapy Effect
Authors: Ding Xin , Wang Tianyu , Bai Shiwei , Yang Mian , Peng Na , Qiu Tao , Liu Yi 
Published: June 2023

AbstractThe purpose of this study is to down‐regulate heat shock proteins and improve the mild photothermal therapy (mild‐PTT) effect of polydopamine (PDA) by preparing the nanosystem of Cu2+ and indocyanine green (ICG)–loaded PDA nanospheres with surface modification of integrin‐targeted cyclic peptide (cRGD) (PDA/Cu/ICG/R), which can limit ATP synthesis through the double mitochondrial destruction pathway. In vitro and in vivo experiments using PDA/Cu/ICG/R irradiated with an NIR laser demonstrate that when NIR is “OFF,” Cu2+ can undergo Fenton‐like reaction in tumor cells, producing a large amount of hydroxyl radicals (·OH), which leads to oxidative stress in cells. This oxidative stress can cause mitochondrial oxidative phosphorylation dysfunction, resulting in limited ATP synthesis. When NIR is “ON,” mild‐PTT can accelerate Cu2+ to produce ·OH. Simultaneously, NIR can activate ICG to produce reactive oxygen species (ROS) storm, amplify intracellular oxidative stress, and continuously damage mitochondria. The biodegradability of PDA greatly reduces the risk of toxicity caused by long‐term retention of PDA/Cu/ICG/R in organisms. Finally, the improvement of the mild‐PTT effect of PDA is successfully achieved through the double mitochondrial destruction pathway of Cu2+ and ICG controlled by NIR “switch.”
Transition Metal‐FreeO‐Arylation ofN‐Alkoxybenzamides Enabled by Aryl(trimethoxyphenyl)iodonium Salts
Authors: Elboray Elghareeb E. , Bae Taeho , Kikushima Kotaro , Kita Yasuyuki , Dohi Toshifumi 
Published: June 2023

AbstractHerein, we develop a metal catalyst‐free protocol forO‐arylation of benzamide hydroxamate esters. The chemoselectiveO‐versus N‐arylation of the amides was tuned by varying the electronic and/or steric properties of the diaryliodonium salt and/or the substrate. TheO‐arylation reaction would preferentially occur for sterically and electronically diverse substrates. This study, which reveals the possibility of substituent‐ and reagent‐controlled chemoselectivity, with diaryliodonium salts might attract interest in the area of hypervalent iodine chemistry.
Alternatives for sustainable weed control in single‐ and double‐cropped soybean: A case study for Mediterranean irrigated conditions
Authors: Simon‐Miquel Genís , Reckling Moritz , Recasens Jordi , Plaza‐Bonilla Daniel 
Published: June 2023

AbstractThe irrigated cropping systems in South Europe could benefit from soybean [Glycine max (L.) Merr.] introduction in their maize (Zea mays L.)‐based crop rotations. However, sustainable weed management strategies are needed for soybean growers under Mediterranean irrigated conditions. This work aimed to assess the weed control efficacy, and the soybean performance, of alternative management practices for single‐ and double‐cropped soybean. Two field experiments were carried out in northeast Spain in the period 2019–2021. Row width narrowing (75–37.5 cm), herbicide application (yes/no), and roller‐crimped rye [Secale cereal (L.) M.Bieb.] cover crop (yes/no) were assessed in the single cropping system experiment (SCS). In the barley‐soybean double cropping system experiment (DCS), row width narrowing and herbicide application were assessed. In the SCS, the presence of rye cover crop reduced weed biomass up to 92% compared to the controls without herbicide and cover crop in 2020. In 2021, no effect of the cover crop on weed pressure was found due to the low amount of rye biomass accumulated (11.8 and 3.4 ton DM ha−1 in 2020 and 2021, respectively). In the DCS, herbicide application attained the expected weed control. Row width narrowing to 37.5 cm did not have an impact on weed pressure nor on soybean yield in either experiment. We concluded that herbicide reduction for single‐cropped soybean under Mediterranean irrigated conditions can be achieved by roller‐crimping a rye cover crop, provided enough rye biomass is accumulated. In the DCS, our results indicated that further research is needed to find alternatives to chemical weed control.
Inflammatory characteristics of central compartment atopic disease
Authors: Rubel Kolin E. , Lubner Rory J. , Lopez Andrea A. , Li Ping , Huang Li‐Ching , Sheng Quanhu , Wu Jeffanie , Wise Sarah K. , DelGaudio John M. , Chandra Rakesh K. , Chowdhury Naweed , Turner Justin H. 
Published: June 2023

AbstractBackgroundCentral compartment atopic disease (CCAD) is an emerging phenotype of chronic rhinosinusitis with nasal polyposis (CRSwNP) characterized by prominent central nasal inflammatory changes. This study compares the inflammatory characteristics of CCAD relative to other phenotypes of CRSwNP.MethodsA cross‐sectional analysis of data from a prospective clinical study was performed on patients with CRSwNP who were undergoing endoscopic sinus surgery (ESS). Patients with CCAD, aspirin‐exacerbated respiratory disease (AERD), allergic fungal rhinosinusitis (AFRS), and non‐typed CRSwNP (CRSwNP NOS) were included and mucus cytokine levels and demographic data were analyzed for each group. Chi‐squared/Mann‐Whitney U tests and partial least squares discriminant analysis (PLS‐DA) were performed for comparison and classification.ResultsA total of 253 patients were analyzed (CRSwNP, n = 137; AFRS, n = 50; AERD, n = 42; CCAD, n = 24). Patients with CCAD were the least likely to have comorbid asthma (p = 0.0004). The incidence of allergic rhinitis in CCAD patients did not vary significantly compared to patients with AFRS and AERD, but was higher compared to patients with CRSwNP NOS (p = 0.04). On univariate analysis, CCAD was characterized by less inflammatory burden, with reduced levels of interleukin 6 (IL‐6), IL‐8, interferon gamma (IFN‐γ), and eotaxin relative to other groups and significantly lower type 2 cytokines (IL‐5, IL‐13) relative to both AERD and AFRS. These findings were supported by multivariate PLS‐DA, which clustered CCAD patients into a relatively homogenous low‐inflammatory cytokine profile.ConclusionsCCAD has unique endotypic features compared to other patients with CRSwNP. The lower inflammatory burden may be reflective of a less severe variant of CRSwNP.
Mechanochemical Rhodium‐Catalyzed C−H Bond Amidation of Ferrocenes by Ball Milling
Authors: Li Hao , Ma Tongtong , Wang Yingxin , Wang Bosen , Li Dianjun , Yang Jinhui 
Published: June 2023

AbstractA direct protocol for Rh‐catalyzed C−H amidation of ferrocenes in a ball mill using dioxazolones as the amide source under solvent‐free conditions was developed. The corresponding ortho‐aminated products were formed in 3 hours and the yields were up to 99% in the absence of base. This method could be a typically sustainable and environmental‐friendly alternative method to traditional methodologies, with the advantages of wide substrate range, good functional group tolerance and gram‐scale synthesis.
Towards a new supply chain manager dashboard under circular economy constraints: A case study on France textile and clothing industry
Authors: Hrouga Mustapha , Michel Stephnaie 
Published: June 2023

AbstractThis paper aims to propose a new dashboard in which we consider all indicators related to the sustainable supply chain (SSC) under circular economy (CE) constraints. As small and medium‐sized enterprises (SMEs) represent 99% of all businesses in the European Union (EU), this study mainly focuses on surveys of French textile and clothing SMEs. It aims to propose a practical and agile tool to help SC managers cope with sustainability challenges and assess the performance of CE implementation in the SC of the textile and clothing industries. To achieve this objective and to develop a relevant questionnaire enabling us to prepare and conduct surveys, we first identified 63 relevant indicators through an extensive exploratory study based on a leading group in luxury and fashion and a pioneer in corporate social responsibility (CSR). Second, we conducted a survey of 46 textile and clothing companies based in France. Finally, we proposed a new comprehensive SC manager dashboard under CE constraints. From the results, we found that there are several barriers to implementing the CE concept in the textile and clothing industry, such as a lack of sustainability performance, a lack of regulation, and a lack of mandatory responsibilities of SC actors. Hence, to cope with these barriers, the SC must be circular and sustainable by highlighting more circular practices such as recycling, eco‐design, compliance with regulations, reducing waste, minimizing greenhouse gas (GHG) emissions, energy, and water consumption. The results revealed that our new proposed dashboard highlights all these concepts that enable us to support textile and clothing SMEs to achieve high sustainable development goals. It can also be used as a decision‐making tool to help SMEs' managers, practitioners, and researchers make better sustainability decisions.
Miliary tuberculosis in an immune‐competent Bangladeshi man—A case report
Authors: Paul Susanta Kumar , Ahmed Shamim , Chakrabortty Rajashish , Paul Shamrat Kumar , Rahman Mohammed Atiqur 
Published: June 2023

AbstractMiliary tuberculosis is a disseminated and active form of tuberculosis caused by Mycobacterium tuberculosis. It frequently affects immunocompromised patients. However, immune‐competent hosts are reported rarely. Herein, we reported a case of miliary tuberculosis of a 40‐year‐old immune‐competent Bangladeshi man presented with pyrexia of unknown origin.
Squaramide‐Based Heteroditopic [2]Rotaxanes for Sodium Halide Ion‐Pair Recognition
Authors: Arun Arya , Docker Andrew , Min Tay Hui , Beer Paul D. 
Published: June 2023

AbstractA series of squaramide‐based heteroditopic [2]rotaxanes consisting of isophthalamide macrocycle and squaramide axle components are synthesized using an alkali metal cation template‐directed stoppering methodology. This work highlights the unprecedented sodium cation template coordination of the Lewis basic squaramide carbonyls for interlocked structure synthesis. Extensive quantitative 1H NMR spectroscopic anion and ion‐pair recognition studies reveal the [2]rotaxane hosts are capable of cooperative sodium halide ion‐pair mechanical bond axle‐macrocycle component recognition, eliciting up to 20‐fold enhancements in binding strengths for bromide and iodide, wherein the Lewis basic carbonyls and Lewis acidic NH hydrogen bond donors of the squaramide axle motif operate as cation and anion receptive sites simultaneously in an ambidentate fashion. Notably, varying the length and nature of the polyether cation binding unit of the macrocycle component dramatically influences the ion‐pair binding affinities of the [2]rotaxanes, even overcoming direct contact NaCl ion‐pair binding modes in polar organic solvents. Furthermore, the cooperative ion‐pair binding properties of the squaramide‐based heteroditopic [2]rotaxanes are exploited to successfully extract solid sodium halide salts into organic media.
Evaluation of the Mass Balance and Metabolic Profile of Futibatinib in Healthy Participants
Authors: Yamamiya Ikuo , Hunt Allen , Yamashita Fumiaki , Sonnichsen Daryl , Muto Toshiharu , He Yaohua , Benhadji Karim A. 
Published: June 2023

AbstractFutibatinib, a selective, irreversible fibroblast growth factor receptor 1–4 inhibitor, was recently approved for FGFR2 rearrangement–positive cholangiocarcinoma. This Phase I study evaluated the mass balance and metabolic profile of 14C‐futibatinib single oral 20‐mg dose in healthy participants (n = 6). Futibatinib was rapidly absorbed; median time to peak drug concentration was 1.0 hours. The mean elimination half‐life in plasma was 2.3 hours for futibatinib, and 11.9 hours for total radioactivity. Mean recovery of total radioactivity was 70% of the dose, with 64% recovered in feces and 6% in urine. The major excretion route was fecal; negligible levels were excreted as parent futibatinib. Futibatinib was the most abundant plasma component, comprising 59% of circulating radioactivity (CRA). The most abundant metabolites were cysteinylglycine‐conjugated futibatinib in plasma (13% CRA) and reduction of desmethyl futibatinib in feces (17% of dose). In human hepatocytes, 14C‐futibatinib metabolites included glucuronide and sulfate of desmethyl futibatinib, whose formation was inhibited by 1‐aminobenzotriazole (a pan‐cytochrome P450 inhibitor), and glutathione‐ and cysteine‐conjugated futibatinib. These data indicate the primary metabolic pathways of futibatinib are O‐desmethylation and glutathione conjugation, with cytochrome P450 enzyme‐mediated desmethylation as the main oxidation pathway. 14C‐futibatinib was well tolerated in this Phase 1 study.
Hierarchical drivers of cryptic biodiversity on coral reefs
Authors: Wolfe Kennedy , Kenyon Tania M. , Desbiens Amelia , de la Motte Kimberley , Mumby Peter J. 
Published: June 2023

AbstractDeclines in habitat structural complexity have marked ecological outcomes, as currently observed in many of the world's ecosystems. Coral reefs have provided a model for such changes in marine ecosystems; still our understanding has been centered on corals and fishes at broad spatial scales when metazoan diversity on coral reefs is dominated by small cryptic taxa (herein: “cryptofauna”). Given the paucity of studies and high taxonomic complexity of the cryptofauna, both of which limit a priori hypotheses, we asked whether hierarchical structuring theory provides a compelling framework to impose order and quantify patterns. In general terms, we explored whether cryptic communities are sufficiently described by broad seascape parameters or limited by a set of processes operating at their distinctly nested microhabitat scale. To address this theory and gaps in knowledge for the cryptofauna, we characterized community structure in coral rubble, an eroded coral condition where biodiversity proliferates. Rubble was sampled along a depth and exposure gradient at Heron Island on the Great Barrier Reef, Australia, to parameterize environmental and morphological indicators of sessile taxa and motile cryptofauna communities. We used a hierarchical study framework from microhabitat to seascape scales, which were evaluated using nonstructured multivariate analyses and Bayesian structural equation modeling. While the nonstructured analyses showed the effects of seascape on the cryptobenthos and its community, this approach overlooked the finer hierarchical patterns in rubble ecology revealed only in the structured model. Seascape parameters (exposure and depth) influenced microhabitat complexity (i.e., rubble branchiness), which determined the cover of sessile organisms on rubble pieces, which shaped the motile cryptofauna community. Rubble is likely to be increasingly prevalent on coral reefs in the Anthropocene and is typically associated with low seascape‐level complexity and reduced macrofaunal richness. Parallel with hierarchical structuring theory, we showed a similar response operating at the microhabitat scale whereby low rubble complexity (i.e., branchiness) reduced cryptobenthic structure, diversity and size spectra. In a future ocean, we expect there may be an initial increase in biodiversity and trophodynamic processes derived from branching rubble, but a delay in ecosystem‐scale outcomes if coral, and thus rubble, generation and complexity is not sustained.
A longitudinal test of secondary transfer effects of negative intergroup contact and mediating processes
Authors: Kauff Mathias , Kotzur Patrick F. , Van Assche Jasper , Schäfer Sarina J , van Zalk Maarten H. W. , Wagner Ulrich 
Published: June 2023

AbstractPositive intergroup contact has not only been shown to be positively associated with favourable attitudes towards members of the contacted group but also with attitudes towards members of secondary outgroups (secondary transfer effect, STE). Only a few studies have addressed a potential STE of negative intergroup contact (i.e., a generalization of negative contact experiences to secondary outgroups). Furthermore, longitudinal studies on STEs and on underlying mediation processes are lacking. In the present research, we investigated the existence of a STE for negative (and positive) intergroup contact in four longitudinal samples with three (Studies 1a and 1b) and two waves (Studies 2 and 3; Noverall = 2052, time lags between waves 2 to 12 months). Our studies did not provide robust evidence for a STE of negative (and positive) contact, nor for indirect STEs via attitude generalization, ingroup identification or diversity beliefs. We discuss implications and suggest avenues for future research.
A commentary on key methodological developments related to nutritional life cycle assessment (nLCA) generated throughout a 6‐year strategic scientific programme
Authors: McAuliffe G. A. , Takahashi T. , Lee M. R. F. , Jebari A. , Cardenas L. , Kumar A. , Pereyra‐Goday F. , Scalabrino H. , Collins A. L. 
Published: June 2023

AbstractRothamsted Research (RRes) is the world's oldest agricultural research centre, notable for the development of the first synthetic fertilizer (superphosphate) and long‐term farming experiments (LTEs) spanning over 170 years. In 2015, RRes recruited several life cycle assessment (LCA) experts and began adopting the method to utilize high resolution agronomical data covering livestock (primarily ruminants), grassland/forage productivity and quality, and arable systems established on its North Wyke Farm Platform (NWFP) and the LTEs. The NWFP is a UK ‘National Bioscience Research Infrastructure’ (NBRI) developed for informing and testing systems science utilising high‐resolution data to determine whether it is possible to produce nutritious food sustainably. Thanks largely to the multidisciplinary knowledge at RRes, and its collaborators, its LCA Team has been at the forefront of methodological advances during a 6‐year Institute Strategic Programme (ISP) ‘Soil‐to‐Nutrition’ (S2N). While S2N investigated the co‐benefits and trade‐offs of new mechanistic understanding of efficient nutrient use across scales from pot to landscape, this commentary specifically synthesizes progress in incorporating human nutrition in the context of environmental footprinting, known as ‘nutritional LCA’ (nLCA). We conclude our commentary with a brief discussion on future pathways of exploration and methodological developments covering various activities along entire agri‐food supply‐chains.
A novel well‐balanced numerical model for water‐solute mixture underflows coupled with ambient water
Authors: Liu Xin , He Junfeng , Jazaeri Seyed Abbas 
Published: June 2023

AbstractThis study considers a water‐solute mixture underflow coupled with ambient water. Such physical phenomenons are modelled by a two‐layer stratified Saint‐Venant system with a scalar transport equation in this paper. The governing system is first relaxed to a hyperbolic system discretized by a path‐conservative algorithm. In such framework, a novel discrete formula of nonconservative and source terms, is proposed to be able to guarantee the well‐balanced property for the hydrodynamic model and preserve the uniform concentration in underflows, especially at wet‐dry fronts. The performances of the developed numerical schemes are verified by several tests.
Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features
Authors: Tsai Ming‐Hsien , Chuang Hui‐Ching , Chien Chih‐Yen , Huang Tai‐Lin , Lu Hui , Su Yan‐Ye , Yang Chao‐Hui , Lai Chi‐Chih , Tsai Wen‐Ling , Lin Yu‐Tsai , Fang Fu‐Min 
Published: June 2023

AbstractBackgroundThe study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features.MethodsIn total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled.ResultsThe optimal LNR cut‐off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016).ConclusionFor HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.
Chirality Induced Nonreciprocity in a Nonlinear Optical Microresonator
Authors: Qie Jinran , Wang Changqing , Yang Lan 
Published: June 2023

AbstractOn‐chip optical nonreciprocity is one of the essential functions to fully advance the development of integrated optical systems, which remains technically challenging in many aspects. There is a great need for mechanisms and approaches to facilitate the large‐scale implementation of nonreciprocal light propagation. Recently, unconventional phenomena, such as chiral optical modes and directional light propagation, have been unraveled at exceptional points (EPs), which are unique degeneracies in the energy spectrum and eigenspace of non‐Hermitian systems. Here, this work theoretically and experimentally demonstrates that by steering a single microresonator with thermo‐optic nonlinearity to chiral EPs, nonreciprocal light propagation is achieved with an isolation ratio up to 24 dB and insertion loss less than 0.5 dB. The nonreciprocity is dependent on the chirality and could be optimized near the EPs. Their results pave new avenues for the nonreciprocal control of light propagation enabled by non‐Hermitian degeneracies and hold great potential for microscale and nanoscale on‐chip nonreciprocal devices.