bluuebunny/crossref_metadata_2025_split huggingface dataset:
Güney Kafkasya Eksenli Değişimlerin Türkiye - Rusya Federasyonu İlişkileri Üzerinden Analizi (Ekim 2020 öncesi süreç)
Authors: TOKER Hülya 
Published: May 2023

1991 yılı Aralık ayı sonlarında SSCB’de meydana gelen dağılmayla birlikte bölgede meydan gelen güç boşluğu, Güney Kafkasya özelinde olduğu gibi bölgesel ve küresel aktörlerin mücadelesini tetikleyen önemli değişikliklerin de habercisi olmuştur. İki kutuplu sistemin istikrarlı politikasının, yerini güvensiz ve istikrarsız bir ortama bırakması, Güney Kafkasya ülkelerinin sahip olduğu değerler nedeniyle bölge içi ve bölge dışı devletlerin odak noktası haline gelmesi çatışmaları da beraberinde getirmiştir. Bölgede meydana gelen değişim, SSCB’nin ardılı olan ve bölgeyi arka bahçesi olarak gören Rusya Federasyonunu (RF) olduğu kadar sınırlarında yepyeni komşularla karşı karşıya gelen ve bölgeyle tarihi ve kültürel bağı olan Türkiye’yi de yakından ilgilendirmiş ve dağılma sonrası her iki ülke bölgeye yönelik yeni politikalar üretmek durumunda kalmıştır.
Çalışmada, Güney Kafkasya’nın önemi ve tarihi arka planı kısaca incelendikten sonra, dağılmadan sonra Güney Kafkasya ülkelerinde yaşanan değişim, bu ülkelerin dış politikasını etkileyen bölge içi etnik çatışmalar, Azerbaycan ve Ermenistan arasında Dağlık Karabağ başta olmak üzere günümüzde dahi yaşanan problemler ve Ermenistan’ın Azerbaycan topraklarına yönelik saldırıları gibi çözülemeyen bölgesel sorunlar, bu sorunlar karşısında Türkiye ve RF’nun izlediği politikalar ve bu politikaların iki ülke ilişkilerine etkisi analiz edilmeye çalışılacaktır.
Gerek RF gerekse Türkiye’nin, Ermenistan ve Azerbaycan gibi çatışma halinde olan devletlerle yakın ilişki içinde olmaları ve Gürcistan’ın etnik meseleleri konusunda Türkiye’nin aldığı tavır gibi hususların iki ülke ilişkilerini zaman zaman olumsuz etkilediği ancak problemleri ayrı tutup ticaret ve turizm gibi ülke çıkarları için önemli konularda anlaşma sağlanabildiği buna rağmen çözülemeyen problemler nedeniyle istikrarın her an bozulabileceği bir süreç yaşandığı değerlendirilmiştir.
“Doğu Kapısında” Macar Havacı Oszkár Asbóth’un Osmanlı Havacılığını Geliştirme Projesi ve İstanbul Günleri (1913)
Authors: KARAGÜLMEZ Müjdat 
Published: May 2023

Osmanlı Devleti, uçakların tarih sahnesine çıktıkları ilk andan itibaren bu hava araçlarına aşina olmuştur. İstanbul’da 1909 yılında yapılan uçuş gösterileri ile Osmanlı halkı ilk defa bu deneyimi yaşamıştır. Avrupalı devletler, uçakların askeri anlamda önemini kısa sürede kavramış ve 1909 yılından itibaren uçakları ordu envanterine almışlardır. Osmanlı Devleti’nin bu dönemde uçaklara ilgisi artmış ve Mahmut Şevket Paşa’nın 12 Ocak 1910 tarihinde Harbiye Nazırı olmasından sonra bu alanda teşkilatlanmaya gidilmiştir. Trablusg Savaşı’nda İtalyan ordusu ilk kez bir uçağı savaş unsuru olarak Osmanlı Devleti’ne karşı kullanması sonrasında Osmanlı hava gücünün gerekliliği bir kez daha ortaya çıkmıştır. Nitekim Osmanlı Devleti’nin içinde bulunduğu mali durum, uçak satın alınmasında bir takım sorunlar yaratmıştır. Bağış kampanyaları ile ilk Osmanlı uçakları alınmış ve Avrupa’ya pilotaj eğitimine gönderilen subayların yurda dönmesiyle bu alanda önemli bir atılım sağlanmıştır. Balkan Savaşları Türk havacılık tarihinde önemli bir yere sahiptir. Bu savaşta, Osmanlı Devleti ilk kez bir savaşta uçak kullanmıştır. Savaşın ilk safhasında Türk havacıları yetersiz kalırken savaşın ikinci safhasında önemli keşif ve gözetleme harekatları icra etmişlerdir.
Savaş devam ederken Macar havacı Oszkár Asbóth’un, Osmanlı havacılığını geliştirmek amacıyla şahsi bir proje başvurusu olmuştur. İstanbul’daki Ganz şirketi müdürü Frigyes Tóbiás ile irtibata geçen Asbóth, Osmanlı Harbiye Nazırlığı ile onun aracılığıyla temas kurmuştur. Asbóth’un Tóbiás aracılığıyla Harbiye Nazırlığına gönderdiği projesi oldukça beğenilmiştir. Bunun üzerine Asbóth, müzakereleri yürütmek amacıyla 13 Ağustos 1913’te İstanbul’a gelmiştir. Asbóth, Harbiye Nazırlığında çeşitli müzakereler yürütmüş ve müzakereler boyunca tayyare mektebinin kurulması, uçak fabrikasının kurulması gibi çeşitli konularda projesini Osmanlı mercilerine iletmiştir. Onun projesi, Osmanlı Harbiye Nazırlığı tarafından çok beğenilmiş ve ön protokoller imzalanmıştır. Nitekim bu gelişmelerden haberi olan Fransızların devreye girmesiyle Asbóth’un projesi beklemeye alınmış ve Birinci Dünya Savaşı’nın çıkması nedeniyle de iptal edilmiştir.
Bu çalışmada, Macaristan’da ve Avrupa’da helikopterin mucidi olarak tanınan Oszkár Asbóth’un Osmanlı havacılığı için geliştirdiği projesi aktarılacaktır. Asbóth’un Harbiye Nazırlığın yapmış olduğu görüşmeleri ve İstanbul günleri bizzat onun hatıratı ışında ele alınacaktır.
Milli Mücadele Dönemi Basınına Göre Bekir Sami Bey’in İstifası ve Hükümet Değişikliği Meselesi
Authors: ÇELEBİ Onur 
Published: May 2023

Kurtuluş Savaşı Dönemi’nde Türkiye Büyük Millet Meclisi görüşmelerinde her daim öne çıkan iki önemli konu olmuştur. Bunlar dış siyaset ve askeri meselelerdir. Vatanın bütünlüğü ve milletin bağımsızlığı mevzularında tüm vekiller hem fikirdir. Ancak amaca giden yolda izlenecek yöntem ve gerekli dış destek hususlarında tam bir birlik sağlanamamıştır. Bu noktada 1921 yılı Mayıs ayı bir kırılma noktasını teşkil etmiştir.
Bu çalışmada, vatanın kurtuluşunu amaç edinmiş ancak metot noktasında anlaşamamış iki ayrı fikri gücün üstünlük mücadelesinin bir nevi basına yansımaları ortaya konulmaya çalışılmıştır. Çalışmada; özellikle dönemin süreli yayınları (Vakit, İleri, İkdam, Akşam, Peyâm-ı Sabah, Tercüman-ı Hakikat, Alemdar, Hâkimiyet-i Milliye) temel alınmış, arşiv belgeleri, meclis zabıt cerideleri ve tetkik eserlerden de istifade edilmiştir.
Makalede, Türkiye’nin ilk Hariciye Vekili Bekir Sami Bey neden istifa etmiştir? Bu istifanın basına akisleri hangi yönde olmuştur? Türk basını Fevzi Paşa başkanlığındaki Heyet-i Vekile’nin istifasını nasıl karşılamıştır? Mustafa Kemal Paşa, ilk mecliste Misak-ı Milli çerçevesinde siyasi ve fikri birliği sağlamak adına hangi adımları atmıştır? Biçimindeki sorulara cevap aranmıştır. Çalışma sonucunda milli mücadelenin yöntemi hususundaki fikri ayrılıkların, Mayıs 1921 tarihinde Mustafa Kemal Paşa liderliğindeki Anadolu ve Rumeli Müdafaa-i Hukuk Grubu’nun ipleri eline almasına bağlı olarak azaldığı tespit edilmiştir.
ACOMPANHAMENTO TERAPÊUTICO E SAÚDE MENTAL
Authors: Conde Bueno Rinaldo 
Published: May 2023

A década de 1960 foi marcante no âmbito das Reformas Psiquiátricas no Ocidente. Outras formas de tratamento foram experimentadas a partir do que o processo de Desinstitucionalização indicou em relação aos cuidados com as pessoas em sofrimento mental. Nesta pesquisa é feita uma revisão bibliográfica sobre novas formas de assistência em saúde mental, ressaltando a prática do Acompanhamento Terapêutico (AT) como um dispositivo potente nessas novas formas de lidar com a loucura. Ainda que pouco difundido no âmbito nacional em serviços substitutivos ao manicômio, pretende-se com este trabalho uma exposição acerca dos cuidados e possibilidades do AT na luta pela cidadania do louco em seu território. Para tanto, a práxis de um fazer clínico peripatético vai ao encontro das prerrogativas de tratamentos desinstitucionalizantes por vislumbrar o povoamento de novos espaços de vida territoriais e em construções de redes fortes no enfrentamento do estigma do louco e de sua exclusão social.
3D bioprinted hydrogel/polymer scaffold with factor delivery and mechanical support for growth plate injury repair
Authors: Fan Minjie , Qiang Lei , Wang Yiwei , Liu Yihao , Zhuang Hanjie , Guo Ruoyi , Ben Yulong , Li Qiang , Zheng Pengfei 
Published: May 2023

Introduction: Growth plate injury is a significant challenge in clinical practice, as it could severely affect the limb development of children, leading to limb deformity. Tissue engineering and 3D bioprinting technology have great potential in the repair and regeneration of injured growth plate, but there are still challenges associated with achieving successful repair outcomes.Methods: In this study, GelMA hydrogel containing PLGA microspheres loaded with chondrogenic factor PTH(1–34) was combined with BMSCs and Polycaprolactone (PCL) to develop the PTH(1–34)@PLGA/BMSCs/GelMA-PCL scaffold using bio-3D printing technology.Results: The scaffold exhibited a three-dimensional interconnected porous network structure, good mechanical properties, biocompatibility, and was suitable for cellchondrogenic differentiation. And a rabbit model of growth plate injury was appliedto validate the effect of scaffold on the repair of injured growth plate. The resultsshowed that the scaffold was more effective than injectable hydrogel in promotingcartilage regeneration and reducing bone bridge formation. Moreover, the addition ofPCL to the scaffold provided good mechanical support, significantly reducing limbdeformities after growth plate injury compared with directly injected hydrogel.Discussion: Accordingly, our study demonstrates the feasibility of using 3D printed scaffolds for treating growth plate injuries and could offer a new strategy for the development of growth plate tissue engineering therapy.
An assessment of the impacts of electronic ticketing on inspections and material procurement for highway construction
Authors: Subramanya Karthik , Kermanshachi Sharareh , Pamidimukkala Apurva , Loganathan Karthikeyan 
Published: May 2023

Introduction: The benefits of incorporating technological advancements and digitalization into construction firms’ inspections and material supply procurement operations have been well documented. Despite this and the availability of the technology, however, there is a pervasive lack of understanding in the industry about the appropriate application(s) and benefits for highway construction. This study aims to 1) assess the merits of e-Ticketing technology based on the benefits it provides to the construction industry, and 2) determine the amount of time that it can save inspectors.Method: A structured survey questionnaire was designed and distributed to a variety of state DOTs to ascertain how they view the benefits of technology, and the advantages cited were ranked according to their importance.Results and Discussion: The time savings that could be realized by incorporating technology into their operations were estimated by comparing the number of personnel required for inspections before and after implementing e-Ticketing and revealed that 24% of the workforce could be eliminated or reassigned. This study contributes to the existing body of knowledge by providing information about how utilizing technology can help state departments of transportation improve the productivity of their workforce, increase safety and morale, minimize schedule delays, mitigate the prevailing shortage of inspection staff, and prepare for the next pandemic or similar event.
Prevalence, predictors, and management for balloon uncrossable or undilatable lesions in patients undergoing percutaneous coronary intervention with in-stent restenosis chronic total occlusion
Authors: Wang Yong , Hou Ai-jie , Luan Bo , Zhang Xiao-jiao , Li Zhao-yu , Pei Xiao-yang 
Published: May 2023

BackgroundPercutaneous coronary intervention for in-stent restenosis (ISR) chronic total occlusion (CTO) has been a great challenge. There are occasions when the balloon is uncrossable or undilatable (BUs) even though the guidewire has passed, leading to failure of the procedure. Few studies have focused on the incidence, predictors, and management of BUs during ISR-CTO intervention.MethodsPatients with ISR-CTO were recruited consecutively between January 2017 and January 2022 and divided into two groups based on the presence of BUs. The clinical data of the two groups (BUs group and non-BUs group) were retrospectively analyzed and compared to explore the predictors and clinical management strategies of BUs.ResultsA total of 218 patients with ISR-CTO were included in this study, 23.9% (52/218) of whom had BUs. The percentage of ostial stents, stent length, CTO length, the presence of proximal cap ambiguity, moderate to severe calcification, moderate to severe tortuosity, and J-CTO score were higher in the BUs group than in the non-BUs group (p &lt; 0.05). The technical success rate and the procedural success rate were lower in the BUs group than in the non-BUs group (p &lt; 0.05). Multivariable logistic regression analysis showed that ostial stents (OR: 2.011, 95% CI: 1.112–3.921, p = 0.031), the presence of moderate to severe calcification (OR: 3.383, 95% CI: 1.628–5.921, p = 0.024) and moderate to severe tortuosity (OR: 4.816, 95% CI: 2.038–7.772, p = 0.033) were independent predictors of BUs.ConclusionThe initial rate of BUs in ISR-CTO was 23.9%. Ostial stents, presence of moderate to severe calcification, and moderate to severe tortuosity were independent predictors of BUs.
Morphological and seismostratigraphic evidence of Quaternary mass transport deposits in the North Ionian Sea: the Taranto landslide complex (TLC)
Authors: Meo Agostino , Senatore Maria Rosaria 
Published: May 2023

The Taranto Landslide Complex (TLC) is a large submarine landslide area located along the continental margin of the Puglia Region, in the Gulf of Taranto (North Ionian Sea), between 200 and 800 m water depth. Based on very high-resolution multibeam data, a morphological analysis was performed by measuring different physical and spatial parameters (i.e., surface, headwall height and length, slope in the source area, and blocks in the accumulation zone). In addition, we use nine high-resolution sub-bottom CHIRP profiles to reconstruct the stratigraphic architecture. The main results show five phases of Quaternary mass transport deposits (MTDs) in the study area. The oldest to the youngest are MTD1, with a volume of about 0.032 km3 and an area of about 4 km2; MTD2, which is the largest of the identified deposits, covering an area of ∼26 km2 and having an estimated volume of ∼0.35 km3; and MTD3 and MTD4, with volumes of about 0.033 km3 and 0.035 km3 and an area of 7 km2 and 5 km2, respectively. The final submarine landslide is represented by MTD5, which has a volume of 0.02 km3. The deposits are internally characterized by chaotic acoustic facies with reflectors with moderate amplitude and laterally continuous in time, showing likely erosive characteristics defined as “bounding surfaces”. The main transport direction of the MTDs is from north/northeast to south/southwest. This represents the trend of the continental slope, but there is also slope failure evidence coming from west/northwest to east/southeast (MTD5). The correlation between topographic and seismo-stratigraphic features allows the documentation of the characteristics, distributions, sources, and the triggering mechanisms of the Late Quaternary MTDs in the area. We suggest that still the unknown trigger mechanisms could be based on the performed analysis, related to the anomalously high sedimentation rates and/or sea level fluctuation.
The association between the interval of radioiodine treatment and treatment response, and side effects in patients with lung metastases from differentiated thyroid cancer
Authors: Wang Hongxi , Shi Lei , Huang Rui , Liu Bin , Tian Rong 
Published: May 2023

ObjectiveRepeat radioiodine (RAI) treatment has been widely implemented for RAI-avid lung metastases and is clinically effective for lung metastatic differentiated thyroid cancer (DTC). We aim to investigate the association between the interval of RAI treatment and short-term response, and the side effects in patients with lung metastases from DTC and to identify predictors for non-effective response to the next RAI treatment.MethodsA total of 282 course pairs from 91 patients were established and categorized into two groups by the interval of neighboring RAI treatment (&lt;12 and ≥12 months), and the characteristics and treatment response between the two groups were compared. Multivariate logistic regression was used to identify predictors associated with treatment response. The side effects in the former course and the latter course were compared while taking into account the interval.ResultsNo significant difference was found between the two groups in treatment response in the latter course (p &gt; 0.05). In the multivariate analysis, age ≥ 55 years (OR = 7.29, 95% CI = 1.66–33.35, p = 0.008), follicular thyroid cancer (OR = 5.00, 95% CI = 1.23–22.18, p = 0.027), and a second RAI treatment as the former course (OR = 4.77, 95% CI = 1.42–18.61, p = 0.016) were significantly associated with a non-effective response. There was no significant difference in the side effects in the former and latter courses between the two groups (p &gt; 0.05).ConclusionThe interval of RAI treatment does not affect short-term response and side effects of DTC patients with RAI-avid lung metastases. It was feasible to defer repeat evaluation and treatment with an interval of at least 12 months to obtain an effective response and reduce the risk of side effects.
The prevalence and genotype of 21-hydroxylase deficiency in the Croatian Romani population
Authors: Dumic Katja K. , Grubic Zorana , Kusec Vesna , Braovac Duje , Gotovac Kristina , Vinkovic Maja , Vucinic Maja , Dumic Miroslav 
Published: May 2023

ObjectiveCongenital adrenal hyperplasia (CAH) owing to 21-hydroxylase deficiency (21-OHD) is a rare autosomal recessive disorder caused by pathological variants in the CYP21A2 gene. After a high prevalence of classic 21-OHD CAH in the Romani population was reported in the Republic of North Macedonia, we decided to estimate the prevalence of 21-OHD in Croatia and, if high, assess the possible causes and estimate the frequency of particular CYP21A2 variants.DesignCross-sectional study.MethodsData from a Croatian 21-OHD genetic database was reviewed, and only Romani patients were included in the study. CYP21A2 genotyping was performed using allele-specific PCR, MLPA, and Sanger sequencing.ResultsAccording to a survey conducted in 2017, Croatia had 22,500 Romani people and six of them had a salt-wasting (SW) form of 21-OHD. All were homozygous for the c.IVS2-13A/C-G pathological variant in intron 2 and descended from consanguineous families belonging to different Romani tribes. The calculated prevalence of 21-OHD in Croatian Romani is 1:3,750, while in the Croatian general population, it is 1:18,000. Three of the six Romani patients originated from two neighboring villages in North-western Croatia (Slavonia County), as well as the seventh patient who is of mixed Romani/Croatian descent and heterozygous for the c.IVS2-13A/C-G pathological variant (not included in the prevalence calculation).ConclusionA high prevalence of SW 21-OHD in the Croatian Romani population caused by the homozygous cIVS2-13A/C-G pathological variant was found. In addition to isolation and consanguinity, other possible reasons could be the heterozygous advantage of the CYP21A2 gene pathological variant and the bottleneck effect as a result of the Romani Holocaust in World War II.
Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway
Authors: Zhao Tianyi , Zhang Zedan , Li Yitao , Sun Zhihua , Liu Liangbo , Deng Xingmei , Guo Jia , Zhu Dexin , Cao Shuzhu , Chai Yingjin , Nikolaevna Usevich Vera , Maratbek Suleimenov , Wang Zhen , Zhang Hui 
Published: May 2023

ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as a model.Materials and methodsRT-qPCR, ELISA and flow cytometry were used to detect the inflammatory factor production and phenotype conversion associated with M1/M2 polarization of macrophages by Brucella abortus infection. Western blot and immunofluorescence were used to analyze the role of nuclear factor kappa B (NF-κB) signaling pathway in regulation of Brucella abortus-induced macrophage polarization. Chromatin immunoprecipitation sequencing (Chip‐seq), bioinformatics analysis and luciferase reporter assay were used to screen and validate NF-κB target genes associated with macrophage polarization and further verify its function.ResultsThe results demonstrate that B. abortus induces a macrophage phenotypic switch and inflammatory response in a time-dependent manner. With the increase of infection time, B. abortus infection-induced M1-type increased first, peaked at 12 h, and then decreased, whereas the M2-type decreased first, trough at 12 h, and then increased. The trend of intracellular survival of B. abortus was consistent with that of M2 type. When NF-κB was inhibited, M1-type polarization was inhibited and M2-type was promoted, and the intracellular survival of B. abortus increased significantly. Chip‐seq and luciferase reporter assay results showed that NF-κB binds to the glutaminase gene (Gls). Gls expression was down-regulated when NF-κB was inhibited. Furthermore, when Gls was inhibited, M1-type polarization was inhibited and M2-type was promoted, the intracellular survival of B. abortus increased significantly. Our data further suggest that NF-κB and its key target gene Gls play an important role in controlling macrophage phenotypic transformation. ConclusionsTaken together, our study demonstrates that B. abortus infection can induce dynamic transformation of M1/M2 phenotype in macrophages. Highlighting NF-κB as a central pathway that regulates M1/M2 phenotypic transition. This is the first to elucidate the molecular mechanism of B. abortus regulation of macrophage phenotype switch and inflammatory response by regulating the key gene Gls, which is regulated by the transcription factor NF-κB.
Dietary inclusion of blood hydrolysates affects muscle growth in European seabass (Dicentrarchus labrax)
Authors: Velasco Cristina , Resende Daniela , Oliveira Beatriz , Canada Paula , Pereira Miguel , Pereira Carlos , Pintado Manuela , Valente Luisa M. P. 
Published: May 2023

Dietary supplementation with hydrolysates has been suggested to influence muscle protein synthesis and fish growth. This study assessed the impact of including 3% swine blood hydrolysates (BH) in a plant-based diet on muscle cellularity and the expression of molecular markers related to muscle fibre proliferation and hypertrophic growth of European seabass. Three BH fractions were obtained by two different processes, autohydrolysis (AH-H) and enzymatic hydrolysis followed by micro- (RMF-H) and nanofiltration (RNF-H). Each BH was added to a commercial-based diet, where 50% of fishmeal was replaced by vegetable proteins (negative control, NC). A fishmeal-based diet was used as positive control, PC. The diets were fed to juveniles (12 g) during 74 days. The RMF group showed down-regulation of myod1 and fgf4, essential to myoblast proliferation and differentiation, and upregulation of mafbx, responsible for protein breakdown, resulting in impairment of muscle hyperplasic growth and the lowest muscle fibres number. However, compensatory growth mechanisms were observed through capn1 downregulation and mymk upregulation, suggesting decreased muscle proteolysis and increased myoblast fusion. Despite this, the compensatory mechanisms were insufficient as RMF group had the worst growth. RNF group had a final weight similar to the NC, but downregulation of fgf4, fgf6 and capn1 may compromise growth potential at long term. The expression of these genes in the AH group was similar to that in the FM-based diet. Despite not having demonstrated growth promotion ability, BH affect muscle growth and cellularity factors, prompting further research on commercial-sized fish to reveal their impact on important commercial traits.