bluuebunny/crossref_metadata_2025_split huggingface dataset:
A machine learning model for textured X-ray scattering and diffraction image denoising
Authors: Zhou Zhongzheng , Li Chun , Bi Xiaoxue , Zhang Chenglong , Huang Yingke , Zhuang Jian , Hua Wenqiang , Dong Zheng , Zhao Lina , Zhang Yi , Dong Yuhui 
Published: April 2023

AbstractWith the advancements in instrumentations of next-generation synchrotron light sources, methodologies for small-angle X-ray scattering (SAXS)/wide-angle X-ray diffraction (WAXD) experiments have dramatically evolved. Such experiments have developed into dynamic and multiscale in situ characterizations, leaving prolonged exposure time as well as radiation-induced damage a serious concern. However, reduction on exposure time or dose may result in noisier images with a lower signal-to-noise ratio, requiring powerful denoising mechanisms for physical information retrieval. Here, we tackle the problem from an algorithmic perspective by proposing a small yet effective machine-learning model for experimental SAXS/WAXD image denoising, allowing more redundancy for exposure time or dose reduction. Compared with classic models developed for natural image scenarios, our model provides a bespoke denoising solution, demonstrating superior performance on highly textured SAXS/WAXD images. The model is versatile and can be applied to denoising in other synchrotron imaging experiments when data volume and image complexity is concerned.
Enhancing ferromagnetic coupling in CrXY (X = O, S, Se; Y = Cl, Br, I) monolayers by turning the covalent character of Cr-X bonds
Authors: Zhu Hao-Ran , Shao Bin , Zuo Xu 
Published: April 2023

AbstractOn the basis of first-principles calculations, we investigate the electronic and magnetic properties of 1T phase chromium sulfide halide CrXY (X = O, S, Se; Y = Cl, Br, I) monolayers in CrCl2 structure with the P$$\overline{3}$$

3

¯

m1 space group. Except for the CrOI monolayer, all CrXY monolayers are stable and ferromagnetic semiconductors. Our results show that the ferromagnetic coupling is dominated by the kinetic exchange between the empty eg-orbital of Cr atoms and the p-orbital of anions under the three-fold rotational symmetry. In this context, the coupling strength allows for being greatly enhanced by turning the nature of Cr–X bonds, i.e., increasing the covalent contribution of the bonds by minimizing the energy difference of the coupled orbitals. As we illustrate for the example of CrOY, the Curie temperature (Tc) is nearly tripled by substituting O by S/Se ion, eventually reaching the highest Tc in CrSeI monolayer (334 K). The high stabilities and Curie temperature manifest these monolayer ferromagnetic materials feasible for synthesis and applicable to 2D spintronic devices.
Kilowatt-scale solar hydrogen production system using a concentrated integrated photoelectrochemical device
Authors: Holmes-Gentle Isaac , Tembhurne Saurabh , Suter Clemens , Haussener Sophia 
Published: April 2023

AbstractThe production of synthetic fuels and chemicals from solar energy and abundant reagents offers a promising pathway to a sustainable fuel economy and chemical industry. For the production of hydrogen, photoelectrochemical or integrated photovoltaic and electrolysis devices have demonstrated outstanding performance at the lab scale, but there remains a lack of larger-scale on-sun demonstrations (>100 W). Here we present the successful scaling of a thermally integrated photoelectrochemical device—utilizing concentrated solar irradiation—to a kW-scale pilot plant capable of co-generation of hydrogen and heat. A solar-to-hydrogen device-level efficiency of greater than 20% at an H2 production rate of >2.0 kW (>0.8 g min−1) is achieved. A validated model-based optimization highlights the dominant energetic losses and predicts straightforward strategies to improve the system-level efficiency of >5.5% towards the device-level efficiency. We identify solutions to the key technological challenges, control and operation strategies and discuss the future outlook of this emerging technology.
Comparison of classical Fabry and its p.D313Y and p.A143T variants by cardiac T1 mapping, LGE and feature tracking myocardial strain
Authors: Avanesov Maxim , Asgari Anahid , Muschol Nicole , Köhn Anja Friederike , Tahir Enver , Adam Gerhard , Kirchhof Paulus , Lund Gunnar , Cavus Ersin , Patten Monica 
Published: April 2023

AbstractCardiac manifestation of classical Fabry disease (cFD) varies with sex and presence of left ventricular hypertrophy. p.D313Y/p.A143T variants (vFD) represent milder late-onset phenotypes, however, data on vFD are scarce. Patients with FD (cFD = 37;vFD = 14) and 14 healthy controls underwent 1.5 T CMR including Cine, LGE, native T1 mapping(nT1) and myocardial strain(CMR-FT). CMR-FT was assessed using ventricular longitudinal, circumferential, radial (LV-GLS/RV-GLS, LV-GCS/LV-GRS), and atrial longitudinal strain (LA/RATotal, LA/RAConduit, LA/RABooster). In cFD reduced myocardial strain (LV-GLS: −20 ± 4 vs. −24 ± 3%,p = 0.007; LV-GCS: −20 ± 4 vs. −26 ± 4%,p = 0.002, LA Total -GLS: 29 ± 10 vs. 37 ± 6%,p = 0.007; LA Conduit -GLS: 15 ± 10 vs. 23 ± 5%,p = 0.003) and nT1 values (951 ± 51 ms vs. 1036 ± 20 ms, p < 0.001) were observed compared to controls. In vFD findings were comparable to controls. LV-GCS provided the closest Area under the curve (AUC) to nT1 (0.84 vs. 0.92, p > 0.05) for discrimination of cFD versus controls. Significantly lower LV-GLS/LV-GCS was found in male compared to female cFD (−19 ± 4 vs. −22 ± 4%, p = 0.03). In six non-hypertrophied female cFD with normal nT1 LATotal -GLS was the only discriminating parameter with an accuracy of 86%. LV-GLS, LV-GCS and LATotal -GLS can detect impaired cardiac mechanics of cFD besides nT1. LATotal -GLS might identify non-hypertrophied female cFD. Variants p.D313Y/p.A143T did not reveal cardiac involvement by multiparametric CMR.
Petrogenesis of juvenile pelletal lapilli in ultramafic lamprophyres
Authors: Prokopyev Ilya , Doroshkevich Anna , Starikova Anastasiya , Kovalev Semen , Nugumanova Yazgul , Izokh Andrey 
Published: April 2023

AbstractThe Chadobets alkaline-carbonatite complex (Siberian craton) is a natural laboratory for all varieties of ultramafic lamprophyres, including damtjernites formed by fluid-explosion mechanisms, which contain a large number of pelletal lapilli. Data obtained from comprehensive mineralogical, structural and chemical studies of these pelletal lapilli show strong similarity with the main magmatic mineral assemblage of damtjernites, suggesting a juvenile composition for them. The composition of phlogopite, carbonate and fluorapatite in pelletal lapilli is mostly constrained toward primitive compositions (beginning) of mineral crystallization trends in ultramafic lamprophyres. According to the petrographic and mineralogical features found in pelletal lapilli from damtjernites, these can be divided into three types based on the conditions and depth of formation. Estimated late magmatic temperatures of pelletal lapilli mica and fluorapatite formation vary from 815 to 990 °C.
Association between cumulative smoking exposure and cognitive decline in non-demented older adults: NEDICES study
Authors: Benito-León Julián , Ghosh Ritwik , Lapeña-Motilva José , Martín-Arriscado Cristina , Bermejo-Pareja Félix 
Published: April 2023

AbstractWhether cumulative smoking exposure is associated with cognitive decline among older adults remains unresolved. To address this question, we used data from the Neurological Disorders in Central Spain (NEDICES) cohort study, in which 2624 older adults were evaluated at two-time points separated by three years. A 37-item version of the Mini-Mental State Examination (MMSE-37) was administered at two visits to assess cognitive change. Regarding smoking exposure, we calculated an individual baseline score based on pack-years (i.e., packs of cigarettes smoked per day multiplied by years of smoking) in current and former smokers. Thus, smoking exposure was categorized into tertiles (low: < 19.0, medium: 19.0–47.0, and high: > 47.0). We used multivariable generalized estimating equation models to assess associations between pack-years and smoking status with 37-MMSE total score change from baseline to follow-up. The MMSE-37 total score had a decline of 1.05 points (confidence interval [CI] 95% 0.62 to 1.48) in the lower tertile of pack-years, 1.16 (CI 95% 0.70 to 1.62) in the middle tertile and 1.17 (CI 95% 0.70 to 1.65) in the higher tertile compared to never smokers, after adjusting for several demographic and clinical variables. The same occurred with smoking status, i.e., a decline of 1.33 (CI 95% 0.87 to 1.79) in current smokers and 1.01 (CI 95% 0.63 to 1.40) in former smokers. Our study provides evidence of the cumulative effect of smoking on cognition in older adults. Using a prospective population-based design, we demonstrated that cumulative smoking exposure was associated with cognitive decline in non-demented older adults. More population-based evidence is required to elucidate this association in older adults without dementia.
High-speed broadband absorption spectroscopy enabled by cascaded frequency shifting loops
Authors: Ogden Hannah M. , Murray Joseph B. , Murray Matthew J. , Redding Brandon 
Published: April 2023

AbstractFrequency shifting loops, consisting of a fiber optic ring cavity, a frequency modulator, and an amplifier to compensate for loss, enable high-speed frequency scanning with precise and easily controlled frequency steps. This platform is particularly attractive for applications in spectroscopy and optical ranging. However, amplified spontaneous emission noise accumulates due to the repeated amplification of light circulating in the cavity, limiting the frequency scanning range of existing frequency shifting loops (FSLs). Here, we introduce a cascaded approach which addresses this basic limitation. By cascading multiple FSLs in series with different frequency shifts we are able to dramatically increase the accessible scanning range. We present modeling showing the potential for this approach to enable scanning over ranges up to 1 THz—a tenfold increase compared with the state-of-the-art. Experimentally, we constructed a pair of cascaded FSLs capable of scanning a 200 GHz range with 100 MHz steps in 10 ms and used this platform to perform absorption spectroscopy measurements of an H13C14N cell. By increasing the operating bandwidth of FSLs, the cascaded approach introduced in this work could enable new applications requiring precise and high-speed frequency scanning.
Adsorption, mobility, and degradation of the pesticide propaquizafop in five agricultural soils in China
Authors: Cheng Zhijia , Hou Zhiguang , Han Hongbo , Yu Xiaolong , Li Jiaxin , Zhao Qinghui , Zhang Ning , Lu Zhongbin 
Published: April 2023

AbstractPropaquizafop is a fatty acid synthetic herbicide used to control annual and perennial grasses. To understand the potential environmental risks of propaquizafop to crops and food safety, the adsorption, mobility, and degradation of propaquizafop in five different soils were studied. At an initial concentration of 5 mg L−1 propaquizafop, its adsorption equilibrium was reached within 24 h, and the adsorption rates were between 46.98 and 57.76%. The Elovich kinetic model provided the best fit for the kinetic model, with R2 values between 0.9882 and 0.9940. For the isothermal adsorption tests, the Freundlich model was used to better fit the adsorption characteristics of propaquizafop in different soils, with R2 values between 0.9748 and 0.9885. Increasing the concentration of Ca2+ was beneficial for propaquizafop adsorption. In the soil thin-layer chromatography tests, the Rf of propaquizafop in the five soil samples ranged from 0.076 to 0.123. The results of the soil column leaching tests showed that propaquizafop did not migrate in the five soil columns; it was not detected in the leachate of each soil column, and propaquizafop in the soil columns only existed in the 0–5 cm soil layer. The results of soil thin-layer chromatography and soil column leaching tests showed that propaquizafop is a pesticide with a weak migration ability. Under the same environmental conditions, the degradation rate of propaquizafop in different soils followed the order LF fluvo–aquic soil (T1/2 = 1.41 d) > CS red loam (T1/2 = 2.76 d) > SX paddy soil (T1/2 = 3.52 d) > CC black soil (T1/2 = 5.74 d) > BS ginseng soil (T1/2 = 7.75 d). Considering the effects of soil moisture, incubation temperature, and microorganisms on propaquizafop degradation in the soil, temperature was found to have the greatest influence on its degradation rate.
Improving the photoelectrochemical water splitting performance of CuO photocathodes using a protective CuBi2O4 layer
Authors: Lam Nguyen Hoang , Truong Nguyen Tam Nguyen , Le Nam , Ahn Kwang-Soon , Jo Younjung , Kim Chang-Duk , Jung Jae Hak 
Published: April 2023

AbstractA heterojunction photocathode of CuO and CuBi2O4 grown on an FTO substrate (FTO/CuO/CuBi2O4) was synthesized using hydrothermal method followed by spin coating and annealing to overcome the bottlenecks encountered by CuO in photoelectrochemical (PEC) water splitting application. The synthesis methods, morphological, structural properties, and composition of each sample under each synthesis condition are discussed in detail. The photocathode with 15 coating layers annealed at 450 °C exhibited the best PEC performance. Moreover, its current density reached 1.23 mA/cm2 under an applied voltage of − 0.6 V versus Ag/AgCl in a neutral electrolyte. Additionally, it exhibited higher stability than the bare CuO thin film. The bonding of CuBi2O4 on CuO resulted in close contact between the two semiconductors, helping the semiconductors support each other to increase the PEC efficiency of the photocathode. CuO acted as the electron-generating layer, and the CuBi2O4 layer helped minimize photocorrosion as well as transport the carriers to the electrode/electrolyte interface to accomplish the hydrogen evolution reaction.
Influence of TRPM4 rs8104571 genotype on intracranial pressure and outcomes in African Americans with traumatic brain injury
Authors: Krocker Joseph D. , Cotton Madeline E. , Schriner Jacob B. , Osborn Baron K. , Talanker Michael M. , Wang Yao-Wei W. , Cox Charles S. , Wade Charles E. 
Published: April 2023

AbstractThe TRPM4 gene codes for a membrane ion channel subunit related to inflammation in the central nervous system. Recent investigation has identified an association between TRPM4 single nucleotide polymorphisms (SNPs) rs8104571 and rs150391806 and increased intracranial (ICP) pressure following traumatic brain injury (TBI). We assessed the influence of these genotypes on clinical outcomes and ICP in TBI patients. We included 292 trauma patients with TBI. DNA extraction and real-time PCR were used for TRPM4 rs8104571 and rs150391806 allele discrimination. Five participants were determined to have the rs8104571 homozygous variant genotype, and 20 participants were identified as heterozygotes; 24 of these 25 participants were African American. No participants had rs150391806 variant alleles, preventing further analysis of this SNP. Genotypes containing the rs8104571 variant allele were associated with decreased Glasgow outcome scale-extended (GOSE) score (P = 0.0231), which was also consistent within our African-American subpopulation (P = 0.0324). Regression analysis identified an association between rs8104571 variant homozygotes and mortality within our overall population (P = 0.0230) and among African Americans (P = 0.0244). Participants with rs8104571 variant genotypes exhibited an overall increase in ICP (P = 0.0077), although a greater frequency of ICP measurements > 25 mmHg was observed in wild-type participants (P =  < 0.0001). We report an association between the TRPM4 rs8104571 variant allele and poor outcomes following TBI. These findings can potentially be translated into a precision medicine approach for African Americans following TBI utilizing TRPM4-specific pharmaceutical interventions. Validation through larger cohorts is warranted.
Protective effect of intensive glucose lowering therapy on all-cause mortality, adjusted for treatment switching using G-estimation method, the ACCORD trial
Authors: Shakiba Maryam , Nazemipour Maryam , Mansournia Nasrin , Mansournia Mohammad Ali 
Published: April 2023

AbstractPrevious analysis of the action to control cardiovascular risk in diabetes showed an increased risk of mortality among patients receiving intensive glucose lowering therapy using conventional regression method with intention to treat approach. This method is biased when time-varying confounder is affected by the previous treatment. We used 15 follow-up visits of ACCORD trial to compare the effect of time-varying intensive vs. standard treatment of glucose lowering drugs on cardiovascular and mortality outcomes in diabetic patients. The treatment effect was estimated using G-estimation and compared with accelerated failure time model using two modeling strategies. The first model adjusted for baseline confounders and the second adjusted for both baseline and time-varying confounders. While the hazard ratio of all-cause mortality for intensive compared to standard therapy in AFT model adjusted for baseline confounders was 1.17 (95% CI 1.01–1.36), the result of time-dependent AFT model was compatible with both protective and risk effects. However, the hazard ratio estimated by G-estimation was 0.64 (95% CI 0.39–0.92). The results of this study revealed a protective effect of intensive therapy on all-cause mortality compared with standard therapy in ACCORD trial.
Accuracy of doppler assessment of the uterine arteries for the diagnosis of pubertal onset in girls: a scoping review
Authors: Cheuiche Amanda Veiga , Moro Candice , Lucena Iara Regina Siqueira , de Paula Leila Cristina Pedroso , Silveiro Sandra Pinho 
Published: April 2023

AbstractThe uterine artery pulsatility index (PI) assessed by Doppler ultrasound reflects the impedance to the blood flow in the vessel distal to the sampling point. We aimed to assess the accuracy of the uterine artery PI for the diagnosis of puberty in girls. A PRISMA-ScR-compliant scoping review was performed in the MEDLINE and Embase databases with the search terms “puberty” and “Doppler ultrasonography”. Studies that included girls aged 0–18 years who underwent pelvic Doppler ultrasound with calculation of uterine artery PI were eligible. Ten studies comprising 1385 girls aged 1.2–18 years were included. The selected studies included participants from Italy, Brazil, Iran, Belgium and Denmark, and were published between 1996 and 2021. Six studies selected girls who were referred for evaluation of pubertal disorders, while four studies included only healthy girls. Nine studies found a significant difference in Doppler signal pattern and PI according to pubertal stage, with PI cutoff points ranging from 2.5 to 4.6 for the diagnosis of puberty, with a sensitivity of 77%–94%, specificity of 85%–100%, and accuracy of 79%–98%. Doppler assessment of the uterine arteries with PI calculation is a useful noninvasive tool in the diagnosis of pubertal onset in girls.
Artificial intelligence to estimate the tear film breakup time and diagnose dry eye disease
Authors: Shimizu Eisuke , Ishikawa Toshiki , Tanji Makoto , Agata Naomichi , Nakayama Shintaro , Nakahara Yo , Yokoiwa Ryota , Sato Shinri , Hanyuda Akiko , Ogawa Yoko , Hirayama Masatoshi , Tsubota Kazuo , Sato Yasunori , Shimazaki Jun , Negishi Kazuno 
Published: April 2023

AbstractThe use of artificial intelligence (AI) in the diagnosis of dry eye disease (DED) remains limited due to the lack of standardized image formats and analysis models. To overcome these issues, we used the Smart Eye Camera (SEC), a video-recordable slit-lamp device, and collected videos of the anterior segment of the eye. This study aimed to evaluate the accuracy of the AI algorithm in estimating the tear film breakup time and apply this model for the diagnosis of DED according to the Asia Dry Eye Society (ADES) DED diagnostic criteria. Using the retrospectively corrected DED videos of 158 eyes from 79 patients, 22,172 frames were annotated by the DED specialist to label whether or not the frame had breakup. The AI algorithm was developed using the training dataset and machine learning. The DED criteria of the ADES was used to determine the diagnostic performance. The accuracy of tear film breakup time estimation was 0.789 (95% confidence interval (CI) 0.769–0.809), and the area under the receiver operating characteristic curve of this AI model was 0.877 (95% CI 0.861–0.893). The sensitivity and specificity of this AI model for the diagnosis of DED was 0.778 (95% CI 0.572–0.912) and 0.857 (95% CI 0.564–0.866), respectively. We successfully developed a novel AI-based diagnostic model for DED. Our diagnostic model has the potential to enable ophthalmology examination outside hospitals and clinics.
National trends in the prevalence of chronic kidney disease among Korean adults, 2007–2020
Authors: Yoon Soo-Young , Park Hye Won , Kim Hyeon Jin , Kronbichler Andreas , Koyanagi Ai , Smith Lee , Shin Jae Il , Rhee Sang Youl , Lee Seung Won , Kim Jin Sug , Hwang Hyeon Seok , Yon Dong Keon , Jeong Kyunghwan 
Published: April 2023

AbstractLittle is known about the prevalence of chronic kidney disease (CKD) during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the long-term trends in CKD prevalence from South Korea including the early pandemic. We used data from 108,152 Korean adults from 2007 to 2020 obtained from a representative longitudinal serial study. We defined CKD as a condition when the participant’s estimated glomerular filtration rate was < 60 mL/min/1.73 m2, or one-time spot proteinuria was ≥ 1 +, and then examined the overall trends in the prevalence of CKD. Among the included adults (n = 80,010), the overall national prevalence of CKD was 6.2%. The trend slope gradually increased from 2007 to 2019, however, there was a sudden decrease in 2020 (2007–2010, 5.1% [95% confidence interval (CI) 4.7–5.5]; 2017–2019, 7.1% [95% CI 6.6–7.6]; pandemic period, 6.5% [95% CI 5.7–7.3]; and βdiff, − 0.19; 95% CI − 0.24 to − 0.13). The prevalence of CKD among younger adults and those with poor medical utilization significantly decreased during the early pandemic. This study was the first large-scale study to investigate the longitudinal prevalence of CKD from 2007 to 2020. Further research is needed to fully understand the exact causes for this decline and to identify healthcare policy strategies for preventing and managing CKD.