bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domain-specific implications of error-type metrics in risk-based software fault prediction
Authors: Phung Khoa , Ogunshile Emmanuel , Aydin Mehmet E. 
Published: January 2025

AbstractIn software development, Software Fault Prediction (SFP) is essential for optimising resource allocation and improving testing efficiency. Traditional SFP methods typically use binary-class models, which can provide a limited perspective on the varying risk levels associated with individual software modules. This study explores the impacts of Error-type Metrics on the fault-proneness of software modules in domain-specific software projects. Also, it aims to enhance SFP methods by introducing a risk-based approach using Error-type Metrics. This method categorises software modules into High, Medium, and Low-Risk categories, offering a more granular and informative fault prediction framework. This approach aims to refine the fault prediction process and contribute to more effective resource allocation and project management in software development. We explore the domain-specific impact of Error-type Metrics through Principal Component Analysis (PCA), aiming to fill a gap in the existing literature by offering insights into how these metrics affect machine learning models across different software domains. We employ three machine learning models - Support Vector Machine (SVM), Random Forest (RF), and Extreme Gradient Boosting (XGB) - to test our approach. The Synthetic Minority Over-sampling Technique (SMOTE) is used to address class imbalance. Our methodology is validated on fault data from four open-source software projects, aiming to confirm the robustness and generalisability of our approach. The PCA findings provide evidence of the varied impacts of Error-type Metrics in different software environments. Comparative analysis indicates a strong performance by the XGB model, achieving an accuracy of 97.4%, a Matthews Correlation Coefficient of 96.1%, and an F1-score of 97.4% across the datasets. These results suggest the potential of the proposed method to contribute to software testing and quality assurance practices. Our risk-based SFP approach introduces a new perspective to risk assessment in software development. The study’s findings contribute insights into the domain-specific applicability of Error-type Metrics, expanding their potential utility in SFP. Future research directions include refining our fault-counting methodology and exploring broader applications of Error-type Metrics and our proposed risk-based approach.
Factors associated with lower forced vital capacity in children and adults with Duchenne muscular dystrophy using non-invasive ventilation: a multicenter analysis
Authors: Sunkonkit Kanokkarn , Hurvitz Manju , Defante Andrew , Orr Jeremy , Chakraborty Abhishek , Amin Reshma , Bhattacharjee Rakesh 
Published: January 2025

Abstract
Background
Reduced forced vital capacity (FVC) is associated with morbidity and mortality in individuals with Duchenne muscular dystrophy (DMD). Non-invasive ventilation (NIV) is often prescribed for the treatment of sleep-disordered breathing (SDB), and chronic respiratory insufficiency. Despite the common practice of initiating NIV later in the progression of DMD, the factors influencing FVC subsequent to the commencement of NIV remain unclear.

Objective
To evaluate the demographic, clinical and socioeconomic determinants of FVC% predicted across several cohorts of DMD children and adults prescribed NIV.

Methods
A multicenter retrospective review of individuals with DMD prescribed NIV was performed between February 2016 to October 2020. Patients were identified from three sites: The Hospital for Sick Children, Canada; Rady Children’s Hospital San Diego, USA; and University of California San Diego Health, USA. Multivariate regression analysis was performed to determine factors that influence FVC.

Results
Fifty-nine male patients with DMD prescribed NIV (mean ± SD for age and BMI was 20.1 ± 6.7 years and 23.8 ± 8.8 kg/m2) were included. Following multivariate analysis, a lower FVC% predicted was associated with older age (β = -1.44, p = 0.001), presence of scoliosis (β = -16.94, p = 0.002), absent deflazacort prescription (β = 14.43, p = 0.009), and use of in-ex sufflator (β = -39.73, p < 0.001), respectively.

Conclusion
In our study, several factors were associated with reduced FVC% predicted in a DMD population using NIV. Future, prospective, longitudinal studies are imperative to comprehend the trajectory of FVC% predicted over time in individuals with DMD using NIV.
Mechanical Cell Interactions on Curved Interfaces
Authors: Buenzli Pascal R. , Kuba Shahak , Murphy Ryan J. , Simpson Matthew J. 
Published: January 2025

Abstract
We propose a simple mathematical model to describe the mechanical relaxation of cells within a curved epithelial tissue layer represented by an arbitrary curve in two-dimensional space. This model generalises previous one-dimensional models of flat epithelia to investigate the influence of curvature for mechanical relaxation. We represent the mechanics of a cell body either by straight springs, or by curved springs that follow the curve’s shape. To understand the collective dynamics of the cells, we devise an appropriate continuum limit in which the number of cells and the length of the substrate are constant but the number of springs tends to infinity. In this limit, cell density is governed by a diffusion equation in arc length coordinates, where diffusion may be linear or nonlinear depending on the choice of the spring restoring force law. Our results have important implications about modelling cells on curved geometries: (i) curved and straight springs can lead to different dynamics when there is a finite number of springs, but they both converge quadratically to the dynamics governed by the diffusion equation; (ii) in the continuum limit, the curvature of the tissue does not affect the mechanical relaxation of cells within the layer nor their tangential stress; (iii) a cell’s normal stress depends on curvature due to surface tension induced by the tangential forces. Normal stress enables cells to sense substrate curvature at length scales much larger than their cell body, and could induce curvature dependences in experiments.
The Impact of Lesion-Specific and Sampling-Related Factors on Success of Salivary Gland Fine-Needle Aspiration Cytology
Authors: Mayer Marcel , Alfarra Mohammad Marwan , Möllenhoff Kathrin , Engels Marianne , Arolt Christoph , Quaas Alexander , Wolber Philipp , Jansen Louis , Nachtsheim Lisa , Grosheva Maria , Klussmann Jens Peter , Shabli Sami 
Published: January 2025

Abstract
Purpose
Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although the performance of salivary gland FNAC (SG-FNAC) has improved since the introduction of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC), the range of the reported performance is still wide. Therefore, the aim of this study was to determine lesion- and sampling-related factors that influence the success of SG-FNAC.

Methods
All SG-FNAC cases performed in a tertiary referral hospital between September 1st, 2011, and August 31st, 2022, were retrospectively identified. Demographic, histopathological, lesion-specific, and sampling-related data were retrieved from the clinical charts. Cytopathological reports were categorized according to the MSRSGC. The risk of malignancy (ROM), the performance measures, and factors influencing the success of SG-FNAC were calculated.

Results
Overall, 1289 cases with histopathological follow-up diagnosis (out of 1952 SG-FNACs) were included. The ROM was: non-diagnostic = 23.9%, non-neoplastic = 4.4%, atypia of undetermined significance (AUS) = 34.5%, neoplasm-benign = 1.0%, neoplasm-salivary gland neoplasm of uncertain malignant potential (SUMP) = 15.3%, suspicious for malignancy = 74.1%, malignant = 96.2%. The sensitivity, specificity, accuracy, positive, and negative predictive value for differentiating benign from malignant lesions (excluding lesions categorized as AUS and SUMP) were 87.5%, 97.7%, 96.3%, 85.0%, and 98.1%, respectively. A larger lesion size (OR (95% CI) = 1.21 (1.06–1.39), p = 0.004), a higher number of obtained slides (OR (95% CI) = 1.31 (1.17–1.46), p < 0.001), and the physician performing the FNAC (p = 0.047) were independent predictors for a higher success, while localization of the lesion within the submandibular compared to the parotid gland (OR (95% CI) = 0.38 (0.19–0.77), p = 0.008) was an independent predictor for lower success of SG-FNAC.

Conclusion
This is the largest single-center study evaluating SG-FNAC performance to date. It identified independent lesion-and sampling-related factors influencing the success of SG-FNAC. Knowledge of those can improve performance of the procedure.
Barriers impacting breast cancer screening during the COVID-19 pandemic among Hispanic women in New Jersey
Authors: Perez-Tucker Raquel , Nelson Anna P. , Lee Jerry W. , Wiafe Seth A. , Handysides Daniel G. 
Published: January 2025

AbstractHispanic women in the United States have been identified as an ethnic group experiencing disproportionately higher mortality rates of breast cancer. These higher rates have been linked to contextual factors that delay breast cancer screening utilization. The COVID-19 pandemic posed a significant disruption to obtaining breast cancer screening affecting utilization of these services especially among minorities. Our cross-sectional study utilized the socio-ecological model (SEM) as a framework to identify barriers influencing delayed utilization using a comprehensive self-administered survey, which was completed among 155 Hispanic and 147 non-Hispanic White women, aged 50 and older, and who resided in the state of New Jersey during the COVID-19 pandemic. Cancer screening attitudes and the extent in which numerous barriers affected utilization of breast cancer screening services during the pandemic were assessed using logistic regression and factor analysis. The analysis confirmed barriers that included low socio-economic status, lack of health insurance, low education attainment, unemployment, limited access to health care services, cancer fatalism, fear of acquiring COVID-19, and linguistic barriers. The findings of this study validate the recommendation of using multi-pronged interventions based on the SEM framework to address both individual and systemic barriers to screening. Breast cancer screening education, resources to access health services and health insurance options may be applied to these vulnerable populations to reduce barriers and facilitate yearly breast cancer screening.
Cognitive Health After Cerebellar Stroke: Potential Link Between Socio-Educational Status and Memory Outcome
Authors: Voruz Philippe , Constantin Ioana Medeleine , Chassot Emilie , Thomasson Marine , Assal Frédéric , Péron Julie Anne 
Published: January 2025

Abstract
While deficits in episodic memory have been noted following cerebellar damage, there is a lack of research systematically exploring the socio-demographic and cognitive profiles of patients with such impairments. This study aimed to differentiate between chronic-phase cerebellar stroke patients with and without verbal episodic memory deficits, and to determine whether those with deficits exhibit distinct socio-demographic and clinical profiles, thereby identifying potential factors associated with these impairments. Data from 15 cerebellar stroke patients in the CEREBEMO cohort were analyzed, with participants categorized into two groups based on verbal episodic memory performance: deficits (n = 8) and no deficits (n = 7). Statistical analyses, including Generalized Linear Mixed Models and Chi-Squared tests, compared socio-demographic and neuropsychological variables between the groups. Significant differences were observed in socio-educational levels, with a higher proportion of patients with memory deficits at intermediate education levels. Moreover, patients with memory deficits performed worse on the Montreal Cognitive Assessment and the Trail Making Test, indicating overall lower cognitive efficiency and slower processing speed. Post-hoc analysis showed that, despite the limited sample size, our sample effectively detected a significant difference between the two groups with high statistical power. These findings highlight potential socio-educational and cognitive factors associated with memory impairments following cerebellar stroke.
Rapid and Deep Responses to Sonidegib Therapy in Elderly Patients With Locally Advanced Basal Cell Carcinomas: Two Case Reports
Authors: Stepan Andreas 
Published: January 2025

AbstractLocally advanced basal cell carcinoma can be a difficult-to-treat disease, particularly in areas such as the face that are sensitive to mutilating surgery or radiotherapy. Hedgehog inhibitors including sonidegib that are administered orally once daily have been developed for the treatment of these patients. The case reports detailed here relate to two over 90-year-old female patients with facial basal cell carcinomas. Their advanced age, comorbidities, and tumor locations close to the eye and on the nose precluded extensive surgery or irradiation. Treatment with sonidegib 200 mg led to rapid and lasting responses, with complete or near-complete regression that eventually enabled curative surgery in one case and preservation of the right eye in the other. Side effects occurred infrequently and were managed using symptomatic therapies as well as dose modification. In addition to surgery and irradiation, sonidegib is an effective and tolerable treatment option for locally advanced basal cell carcinoma that can be expected to work in any age group.
High levels of genetic connectivity in the corallivorous gastropod Drupella cornus (Rӧding, 1798) in an expanding latitudinal range along Western Australia
Authors: Haslam Veera M. , Maroni Paige J. , Chaplin Jennifer A. , Bessey Cindy , van Keulen Mike 
Published: January 2025

AbstractUnderstanding connectivity in high impact corallivores is crucial for coral reef management. The obligate corallivorous Drupella cornus (Röding, 1798) has caused extensive damage to some Indian Ocean coral reef areas in the last four decades. This study used novel and previously published Cytochrome Oxidase I (COI) sequences to reveal patterns of genetic diversity, phylogeography and connectivity within D. cornus across the Indian Ocean. The genetic compositions of the Western Australian D. cornus groups from Ningaloo Reef, Houtman Abrolhos Islands, and a recently discovered group at Rottnest Island, were analysed and compared to D. cornus groups from the western Indian Ocean (Tanzania and the Gulf of Eilat). The findings indicated that these groups all belong to the same species, except for a few individuals from Rottnest Island, which were excluded from subsequent analyses. No genetically distinct D. cornus groups along the Western Australian coastline were found, whereas molecular population differences were seen between the western Indian Ocean D. cornus groups and the Western Australian D. cornus groups. The molecular differences between the Western Australian and Tanzanian groups were statistically significant; however, there was evidence of historic connections and possibly also occasional long-distance gene flow between these groups. We hypothesise that high-density D. cornus outbreaks have played an important role in the dispersal of this species across Western Australia and, more broadly, the Indian Ocean. This is important as Drupella spp. outbreaks are being reported more frequently in the Indo-Pacific, affecting coral reef health and ecosystem function.
Required informational barriers to accessing groceries from food banks
Authors: Millerschultz Alexis , Nalley Lawton Lanier , McFadden Brandon , Nayga Rodolfo , Yang Wei 
Published: January 2025

Abstract
Requirements to obtain groceries from a food pantry (e.g., forms of identification) can create potential “documentation barriers” to participation. A more holistic understanding of potential barriers are obtaining assistance from food pantries, specifically in the United States of America (USA), is warranted due to inflation in food prices, reduction of enhanced COVID-related SNAP benefits, and the increased demand for food pantry participation. In May of 2022, a survey was administered to low-income households across the USA that received groceries from a food pantry the previous month. Food pantry participants were asked which pieces of information were required to obtain groceries during their food pantry visit, including requirements to provide a home address, place of employment, Social Security Card, driver’s license, household size, blood test, and an “other” option in case they were asked to provide something beyond the previous requirements listed. On average, respondents were asked to provide 2.4 pieces of information (out of seven) when visiting a food pantry. Results indicated that 56% of African Americans had to provide their Social Security Card, which was significantly higher than the 21% of White food pantry participants, and requiring a Social Security Card is one of the most significant known barriers to obtaining food assistance. Further, probit model results indicated that the groups most susceptible to being food insecure (e.g., minorities, females, and SNAP-using individuals) were between 11 and 28% more likely to experience more documentation barriers to accessing groceries from a food pantry.
Assessment of agricultural residues for small-scale biogas plants and adoption drivers: a case study of the Fès-Meknès region in Morocco
Authors: Ngetuny Joshua , Hsaine Jalal , Mabrouki Abdelaalim , Rachidi Fouad , El Asli Abdelghani , Zörner Wilfried 
Published: January 2025

AbstractSmall-scale biogas systems hold promise as reliable renewable energy sources in developing nations; however, adequate and consistent supply of feedstock remains a challenge. Agricultural residue, due to their lack of competition with food crops for resources, is touted as a dependable feedstock choice. This article therefore examines agricultural residues as potential biogas plant feedstocks in the Fès-Meknès region of Morocco, using a structured farm survey to evaluate livestock types, crop varieties, and residue utilization. Additionally, the study explores the challenges and drivers influencing biogas technology adoption in Morocco. Findings indicate a predominance of small-scale farms with livestock (averaging 11 cattle, 45 sheep, and 20 chicken) and mainly subsistence crop production, making these farms suitable candidates for small-scale biogas plants. Key barriers to adoption include a lack of awareness about the technology, along with technical and financial constraints. However, raising awareness, establishing demonstration plants, and offering financial and non-financial incentives are identified as potential drivers of adoption. This research provides a foundation for implementing biogas technologies in the case study area and other developing nations, guiding researchers and governmental and non-governmental organizations in disseminating small-scale biogas systems as a reliable energy source and a method for converting agricultural residues into sustainable energy (biogas) and fertilizer.
Graphical Abstract
In vivo anti-plasmodial activity of alpha-onocerin and artesunate combination against Plasmodium berghei infected mice
Authors: Kwansah-Obresi Jacob Hammurabi , Moomin Aliu , Forkuo Arnold Donkor , Antwi Aaron Opoku , Addotey John Nii Adotey , Adu-Gyamfi Paa Kofi Tawiah , Sidik Abubakar Ibn , Mensah Kwesi Boadu 
Published: January 2025

AbstractAlpha-onocerin is a triterpenoid derived from Huperzia phlegmaria which is used in ethnomedicine for the treatment of fever, headaches, pains and malaria. This study was conducted to evaluate the safety, antipyretic and anti-plasmodial activity of alpha-onocerin and artesunate (ART) co-administration in ICR mice for use in traditional medicine.The anti-plasmodial effects of alpha-onocerin (10, 30, 100, 300 mg/kg) and ART (1, 2, 4, 8, 16 mg/kg) were assessed in P. berghei-infected mice. Alpha-onocerin /ART were administered with a fixed dose combination of their median effective doses (ED50s) to determine the experimental ED50 (Zexp). An isobologram was developed to identify the nature of the interaction by comparing Zexp with the theoretical ED50 (Zadd).Alpha-onocerin (300 mg/kg) showed a similar chemosuppression (93.51 ± 2.15%) to ART (2 mg/kg, i.p.) of 97.02 ± 0.27% in the 4-day suppressive test as well as in the prophylactic test with chemosuppression at 54.94% and 69.76% for alpha-onocerin (300 mg/kg) and artesunate (2 mg/kg, i.p.) respectively. All doses of alpha-onocerin significantly (p < 0.05) reduced pyrexia in 1 h and 2 h after their administration in the baker’s yeast test. ED50s for ART and alpha-onocerin were 1.33 ± 0.11 and 13.64 ± 0.22 mg/kg, respectively. The Zadd, Zexp and interaction index for alpha-onocerin /ART co-administration were 7.49 ± 3.46, 1.61 ± 0.78 and 0.22 respectively. The Zexp for alpha-onocerin /ART laid below the additive isobole indicating significant (p < 0.001) synergistic activity with ART.Alpha-onocerin showed analgesic effects, antipyretic and synergistic anti-plasmodial effects in P. berghei-infected mice.
Anticipatory Violence and Health Among Black Adults in the United States
Authors: Semenza Daniel C. , VanHook Cortney , Baker Nazsa S. , Savage Brielle 
Published: January 2025

AbstractThis study analyzes the relationship between anticipatory community and police violence and health outcomes including mental and physical well-being, sleep problems, and functional disability. Using data from a nationally representative survey of 3015 self-identified Black and African American adults in the USA collected in 2023, findings from a series of regression analyses reveal that anticipating community violence is linked to poorer self-rated health and increased sleep problems. Anticipatory police violence is associated with poorer physical health and sleep disturbances. These associations persist even after accounting for previous experiences of violence. The results underscore the potential health consequences of anticipating violence, suggesting that the fear of personal victimization can adversely influence health. Addressing anticipatory violence through trauma-informed public health policies and practices is critical for improving health outcomes and reducing disparities in violence-exposed communities. Future research should explore longitudinal impacts and extend analyses to additional racial groups and health outcomes.
Geolocation-Aware Deep Coding
Authors: Madadikhaljan Mojgan , Schmitt Michael 
Published: January 2025

Abstract
With more and more remote sensing data available on a global scale, the Earth observation community strives to harness the power of modern deep learning techniques by developing globally applicable models. However, remote sensing images exhibit strongly heterogeneous, geolocation-dependent characteristics, making this a challenging endeavor. In this paper, we introduce the geolocation-aware deep coding strategy to incorporate geolocation information of remote sensing data into the training of the deep learning models. The proposed method consists of defining regional subnetworks dedicated to each subset of the dataset with similar geolocational characteristics. Using two application examples, namely the mapping of building footprints from multi-spectral Sentinel‑2 imagery, and the task of forest detection from single-channel thermal infrared Landsat imagery, we show that the proposed deep coding strategy stabilizes the training performance and can also improve the predictive power of deep neural networks designed for remote sensing data analysis.