bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequence matters: Total body irradiation (TBI)‐based myeloablative conditioning with post‐transplant cyclophosphamide may reduce the early nonrelapse mortality compared with pretransplant cyclophosphamide plus TBI
Authors: Redondo Sara , García‐Cadenas Irene , Vila Antonio , Esquirol Albert , Portos J. M. , Novelli Silvana , Saavedra Silvana , Moreno Carol , Garrido Ana , Arguello‐Tomas Miguel , Oñate Guadalupe , López‐Pardo Jordi , Caballero Ana‐Carolina , Miqueleiz Sara , Briones Javier , Sierra Jorge , Sancho Gemma , Martino Rodrigo 
Published: April 2023

AbstractObjectivesHigh‐dose total body irradiation (TBI) is considered a cornerstone of myeloablative conditioning for allogeneic stem cell transplantation (allo‐SCT). We retrospectively compared the main outcomes of an HLA matched or 1‐allele mismatched related or unrelated allo‐SCT in adult patients affected by acute leukemia (AL) or myelodysplastic syndromes (MDS).MethodsFifty‐nine patients received cyclophosphamide (Cy)‐TBI (13.5 Gy) and graft‐versus‐host disease (GVHD) prophylaxis with a calcineurin‐inhibitor plus methrotrexate (CyTBI group) and 28 patients received fludarabine‐TBI (8.8–13.5 Gy) and GVHD prophylaxis with PTCy and tacrolimus (FluTBI‐PTCy group).ResultsMedian follow‐up for survivors was 82 and 22 months. The 12‐month probability of overall survival and progression‐free survival were similar (p = .18, p = .7). The incidence of Grades 2–4 and 3–4 acute GVHD, and the incidence of moderate‐to‐severe chronic GVHD were higher in the CyTBI group (p = .02, p < .01and p = .03). Nonrelapse mortality (NRM) at 12 months posttransplant was higher in the CyTBI group (p = 0.05), while the incidence of relapse was similar in both groups (p = 0.7). The number of GVHD‐free and relapse‐free patients without systemic immunosuppression (GRFS) at 1‐year posttransplant was higher in the FluTBI‐PTCy group (p = 0.01).ConclusionsThe study confirms the safety and efficacy of a novel FluTBI‐PTCy platform with reduced incidence of severe acute and chronic GVHD, and early improvement of NRM.
Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?
Authors: Chularojanamontri Leena , Rattanakorn Krittaya , Julanon Narachai , Chuamanochan Mati , Griffiths Christopher E. M. 
Published: April 2023

AbstractPustular psoriasis is characterised by eruptions of neutrophilic sterile pustules. The European Rare and Severe Psoriasis Expert Network consensus defines pustular psoriasis into three subtypes; generalised pustular psoriasis (GPP), palmoplantar pustulosis and acrodermatitis continua of Hallopeau (ACH). Mixed forms are categorised according to their predominant features. However, the Japanese Dermatological Association includes ACH under the diagnosis of GPP. This article aims to review the similarities and differences between ACH and GPP. Based on our review, interleukin (IL)‐36RN mutations, the most frequent genetic findings in pustular psoriasis are found most commonly in GPP, followed by ACH. Genotypes of IL‐36RN mutations among GPP patients and ACH patients are different between European and Asian ethnicities. IL‐36 signalling pathway is the main mechanism. Metabolic diseases are common comorbidities and joint involvement can occur in 20.5%–36.4% of both conditions. Associated plaque psoriasis is more common in GPP than in ACH. Generally, ACH, even the generalised type, does not have systemic inflammation whereas GPP can occur with or without systemic inflammation. ACH can occur before, simultaneously, or after the development of GPP. However, response to treatment for GPP and ACH even in the same patients appear to be different. ACH seemed to be more recalcitrant to treatment than GPP but severe flare of GPP can lead to morbidity and mortality. Although GPP and ACH share genotypes and pathogenesis, we believe that ACH should be classified separately from GPP, and not under diagnosis of GPP. Future research is warranted to satisfactorily distinguish the two conditions.
Internationalization policy in Japanese university prospectuses
Authors: Morel Robert C. 
Published: April 2023

AbstractThis paper analyses international student prospectuses from twenty‐two Japanese universities involved in the Top Global University Program (TGUP) to examine how universities in Japan present and understand internationalization. International prospectuses were analysed using qualitative text analysis to generate a series of themes connected to university internationalization. Different categories of TGUP participant universities were compared to better understand the differences between how different participant types present and understand internationalization. The findings suggest that while there are differences between participant types and individual universities, overall, there appears to be a tension between understanding internationalization as an authoritative, university‐centred activity and as a student‐centric activity in which students are active participants. Furthermore, it found that although rankings are an important aspect of the TGUP, few prospectuses mentioned rankings. The paper suggests possible reasons for this omission based on the TGUP participant type. Finally, this study offers insights into how Japanese universities understand internationalization and position themselves as international institutions.
Efficacy of imaging techniques for the diagnosis of apical periodontitis: A systematic review
Authors: Hilmi Ali , Patel Shanon , Mirza Kazim , Galicia Johnah C. 
Published: April 2023

AbstractBackgroundApical periodontitis (AP) is a chronic inflammatory response of microbial aetiology. Pathological changes associated with AP may not be visible on radiographic images and may linger without causing any symptoms. Clinicians rely mostly on clinical examination and imaging techniques to establish a diagnosis.ObjectivesThe aim of this review was to answer the following question using the PICO format: In the adult human permanent dentition (P), what is the efficacy of diagnostic imaging of the periapical tissues (I) using histopathology as a reference standard (C) in the diagnosis of apical periodontitis, in terms of diagnostic accuracy (O).MethodsMEDLINE, EMBASE, Scopus and Cochrane Library were searched for English articles published through October 2021. At least two independent reviewers evaluated the study design, imaging modality used, histopathological assessment, outcome measures, results and conclusions for each article. The risk of bias was assessed using the Quality Assessment Tool for Diagnostic Accuracy Studies‐2.ResultsThe initial search strategy identified 544 articles. Seven articles were included for analysis in the final review, all of which involved tissue samples obtained from cadavers. No clinical studies were identified that met the eligibility criteria. A consistently low sensitivity score and negative predictive value were reported for periapical radiography, especially in comparison to CBCT, which scored highly. Both modalities achieved high scores for specificity and positive predictive value. Diagnostic accuracy of CBCT was lower for root‐filled teeth in comparison to non‐root‐filled teeth.DiscussionAssessment of the periapical tissues using periapical radiographs was shown to have a low to moderate agreement with the histopathological assessment. CBCT was reported to be more accurate than PR and demonstrated a good agreement with histopathology, especially for non‐root‐filled teeth.ConclusionsThis review identified a need for greater standardization in methodology and reporting, and as the findings are based on cadaver studies, their clinical relevance must be interpreted with caution.RegistrationPROSPERO (CRD42021272147).
Influence of perceived benefits, barriers and activities of family engagement in care on family nursing practice: A cross‐sectional correlational study
Authors: Kiwanuka Frank , Nanyonga Rose Clarke , Sak‐Dankosky Natalia , Kvist Tarja 
Published: April 2023

AbstractAimsTo describe nurses' perceptions of family nursing practice and to explore the influence of their perceptions of the benefits, barriers and activities of family engagement in care on family nursing practice.DesignA cross‐sectional correlational study.MethodsIn total, 460 nurses from two tertiary hospitals in the central region of Uganda participated. Quantitative and qualitative data were collected between August 2020 and January 2021 using the Family Nursing Practice Scale. Analyses included descriptive statistics, t‐test, Pearson correlation, analysis of variance and ordinal logistics regression. Quantitative content analysis was carried out on the textual data.ResultsNurses who perceived that family engagement in care improves patient and family outcomes were more likely to rate family nursing practice highly. Perceived barriers to family engagement in care particularly time constraints, work overload and family‐related conflicts have a negative and significant influence on family nursing practice. Nurse characteristics such as education, usual shift pattern and personal experience of having a family member in hospital are significantly associated with family nursing practice; nurses who work morning shifts were likely to report higher family nursing practice.ConclusionThe study reveals that several parameters (perceived barriers, perceived benefits and nurse characteristics) influence nursing practice with families. Thus, bearing in mind the diversity of healthcare contexts, the findings show that multiple interacting factors are important for advancing family nursing interventions and practice.ImpactProbabilistic factor‐specific predictions of nursing practice with families are provided in this study – this addresses a gap in the evidence regarding the elements that should be optimized when designing well‐informed policies and interventions to advance family nursing practice. A comparison of results in the literature with the present study's findings suggests a need to broaden the scope and context perspective in future research and broaden the understanding of how nurses´ perceptions influence family engagement in care.Reporting methodThe study adheres to the STROBE reporting guidelines.Patient or public contributionFamily members/caregivers were involved in the design of the study particularly in assessment of validation of the tools used in the study.
Investigating the scope and costs of dental treatment provided under general anaesthesia among children with congenital heart disease
Authors: Nikolovski Jana , Chapman Emily E , Widmer Richard P , Ayer Julian G 
Published: April 2023

AimTo identify the types of dental treatment provided under general anaesthesia for children diagnosed with congenital heart disease (CHD), quantify the costs within a publicly funded tertiary paediatric hospital setting and identify factors which affect the cost.MethodsA retrospective analysis of dental records (July 2015 to June 2019) was conducted for children with CHD who had undergone a dental general anaesthetic procedure at The Children's Hospital at Westmead, Australia. Patient and treatment‐related information were collected, and a costing analysis was performed on 89 dental general anaesthetic procedures.ResultsMean age at the time of the general anaesthetic was 8.15 years. About 27% of children with CHD had a history of dental infection. Dental extractions and restorations comprised the majority of treatments provided, with extractions performed in 86% of procedures. The mean number of days in hospital was 1.43 and the mean cost was $4395.14. The cost was significantly greater when children presented with a facial swelling compared to any other reason.ConclusionsDental extractions are performed in the majority of general anaesthetics. Not only is there an economic burden to the public health system in providing dental treatment under general anaesthesia for children with CHD, the health impacts also appear to be substantial. A considerable proportion required overnight hospitalisation and days in hospital was strongly related to the cost of the dental general anaesthetic. Systematic referral pathways for accessing dental care are an important consideration for children with CHD.
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression
Authors: Nguyen Bao Tran , Lin Chih‐Yang , Chang Ting‐Kuo , Fong Yi‐Chin , Thadevoos Louis Anoop , Lai Chao‐Yang , Huang Yuan‐Li , Tsai Chun‐Hao , Ko Chih‐Yuan , Liu Ju‐Fang , Yang Shun‐Fa , Tang Chih‐Hsin 
Published: April 2023

AbstractChondrosarcoma has a high propensity to metastasize and responds poorly to chemotherapy and radiation treatment. The enzymatic activity of matrix metalloproteinases (MMPs) is very important in chondrosarcoma metastasis. Melatonin exhibits anticarcinogenic activity in many types of cancers by suppressing the expression of certain MMP family members, but this has not yet been clearly determined in chondrosarcoma. Our study demonstrates that MMP7 plays an essential role in chondrosarcoma cell proliferation, migration, and anoikis resistance. We also found that MMP7 is highly expressed in chondrosarcomas. Our in vitro and in vivo investigations show that melatonin strongly inhibits chondrosarcoma cell proliferation, migration, and anoikis resistance by directly suppressing MMP7 expression. Melatonin reduced MMP7 synthesis by promoting levels of miR‐520f‐3p expression, which were downregulated in human chondrosarcoma tissue samples. Pharmacological inhibition of miR‐520f‐3p markedly reversed the effects of melatonin upon chondrosarcoma proliferation and metastasis. Thus, our study suggests that melatonin has therapeutic potential for reducing the tumorigenesis and metastatic potential of chondrosarcoma via the miR‐520f‐3p/MMP7 axis.
Insomnia trajectories predict chronic inflammation over 2 years at the transition to adulthood
Authors: Zhai Shuang , Li Tingting , Zhang Dan , Qu Yang , Xie Yang , Wu Xiaoyan , Zou Liwei , Tao Fangbiao , Tao Shuman 
Published: April 2023

SummaryInsomnia in adolescents is an important public health concern, as its impacts on both their current and future physical and mental health has been discussed. However, few longitudinal studies have examined insomnia and chronic inflammation at the transition from adolescence to adulthood. This study aimed to examine the predictive effects of insomnia and insomnia trajectories on inflammation in college students by using a prospective design. Using data from the College Student Behaviour and Health Cohort Study, which was conducted between April 2019 and April 2021, with an interval of 6 months. We investigated the associations between insomnia trajectories from Year 1 to Year 3 and five inflammatory biomarkers (C‐reactive protein [CRP], tumour necrosis factor [TNF]‐α, interleukin [IL]‐6, IL‐1β, IL‐10) at Year 3. The association of insomnia symptoms at baseline, Wave 1 or Wave 2 with inflammatory biomarkers at Wave 4 were also assessed. A total of 312 college students (males: 51.6%) aged 16–26 years (mean [SD] 18.82 [1.22] years) were analysed. We identified two insomnia trajectory classes: increasing insomnia (n = 63 [20.2%]) and decreasing insomnia (n = 249 [79.8%]). Generalised linear model analysis revealed that insomnia symptoms at Wave 1 were associated with significantly elevated CRP and TNF‐α levels at Wave 4. Increasing insomnia trajectories predicted consistently higher levels of CRP, TNF‐α and IL‐10. However, after adjusting for potential confounders, these associations were significantly attenuated. Overall, the findings suggest that insomnia symptoms affect chronic inflammation at the transition to adulthood. Our study needs to be replicated in larger cohorts to further explore how inflammation interacts with insomnia to increase the susceptibility to adverse health conditions.
Plasma and urinary metanephrine and normetanephrine concentrations using liquid chromatography with tandem mass spectrometry in healthy cats and in a cat with pheochromocytoma
Authors: Prego Maria Teresa , Dias Maria Joana , Ferreira Rui Lemos , Gonçalves Salomé , Dias Domingues Tiago , Junius Greet , Van den Steen Evi , Galac Sara , Leal Rodolfo Oliveira 
Published: April 2023

AbstractBackgroundPheochromocytoma (PCC) is rare in cats and plasma (PL) and urinary (U) metanephrines (metanephrine [MN]; normetanephrine [NMN]) measurement is rarely described in cats.ObjectivesWe evaluated the utility of PL and U MNs measurement in 10 healthy cats and a cat with a confirmed diagnosis of pheochromocytoma (PheoCat), using liquid chromatography with tandem mass spectrometry (LC‐MS‐MS).MethodsUrine and EDTA PL samples collected from each of the 10 cats and the PheoCat were promptly stored at −80°C and remained frozen until analysis. To evaluate U MNs stability, an additional urine sample collected from the healthy cats was refrigerated for 24 hours before freezing. Urinary creatinine concentration (Creat) was assessed using the same spot urine samples to calculate U MNs‐to‐creatinine ratios.ResultsThe PL‐MN and PL‐NMN median concentrations of the healthy cats were 2.73 and 7.02 nmol/L, respectively. The median U‐MN/Creat and U‐NMN/Creat ratios were 70 and 139 μg/g, respectively. The PheoCat had a PL‐MN of 3.68 nmol/L, PL‐NMN of 66.27 nmol/L, U‐MN/Creat of 179 μg/g, and U‐NMN/Creat of 1262 μg/g. The PheoCat had markedly increased concentrations of both PL and U MNs when compared to the healthy cats. No significant difference was found between U MNs measured in urine samples that underwent 24 hours of refrigeration in comparison to those that were frozen immediately.ConclusionsWe report preliminary reference intervals for PL and U MNs in cats using LC‐MS‐MS and the potential clinical applicability of these biomarkers for the diagnosis of PCC in cats.
Trust plays no role in regional U.S. economic development—And five other problems with the trust literature
Authors: Forrester Andrew C. , Nowrasteh Alex 
Published: April 2023

AbstractEconomists have developed a vast empirical literature on how cultural traits like generalized trust affect economic output. Much of this literature finds a positive causal relationship between measures of generalized trust, as gathered by international surveys, and economic output. However, the trust literature commits five deadly empirical and theoretical sins that undermine many of its findings. From the quality of the survey questions and responses to the paucity of theoretical models used to explain how trust affects economic outcomes to the radically different results from experimental evidence and others, the trust literature is riven with poor methods and bad data. Even so, applying common methods used in the trust literature to regional level analysis in the United States during the 1972–2018 period reveals no statistically significant correlation between economic output and trust. Given our lack of findings at the subnational level, we find further evidence to be skeptical of the trust literature.
Anatomical drivers of stomatal conductance in sorghum lines with different leaf widths grown under different temperatures
Authors: Al‐Salman Yazen , Cano Francisco J. , Pan Ling , Koller Fiona , Piñeiro Juan , Jordan David , Ghannoum Oula 
Published: April 2023

AbstractSustaining crop productivity and resilience in water‐limited environments and under rising temperatures are matters of concern worldwide. We investigated the leaf anatomical traits that underpin our recently identified link between leaf width (LW) and intrinsic water use efficiency (iWUE), as traits of interest in plant breeding. Ten sorghum lines with varying LW were grown under three temperatures to expand the range of variation of both LW and gas exchange rates. Leaf gas exchange, surface morphology and cross‐sectional anatomy were measured and analysed using structural equations modelling. Narrower leaves had lower stomatal conductance (gs) and higher iWUE across growth temperatures. They also had smaller intercellular airspaces, stomatal size, percentage of open stomatal aperture relative to maximum, hydraulic pathway, mesophyll thickness, and leaf mass per area. Structural modelling revealed a developmental association among leaf anatomical traits that underpinned gs variation in sorghum. Growing temperature and LW both impacted leaf gas exchange rates, but only LW directly impacted leaf anatomy. Wider leaves may be more productive under well‐watered conditions, but consume more water for growth and development, which is detrimental under water stress.
Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors
Authors: Dwertmann Rico Sebastian , Schliesser Sebastian J. A. , Gorbokon Natalia , Dum David , Menz Anne , Büscheck Franziska , Hinsch Andrea , Lennartz Maximilian , von Bargen Clara , Bawahab Ahmed A. , Luebke Andreas M. , Hube‐Magg Claudia , Fraune Christoph , Lebok Patrick , Clauditz Till S. , Jacobsen Frank , Sauter Guido , Uhlig Ria , Steurer Stefan , Minner Sarah , Marx Andreas H. , Simon Ronald , Burandt Eike , Hoeflmayer Doris , Krech Till , Bernreuther Christian 
Published: April 2023

AbstractMucin 6 (MUC6) is a secreted gel‐forming mucin covering the surfaces of gastrointestinal and other tissues. Published work demonstrates that MUC6 can also be expressed in several cancer types and can aid in the distinction of different tumor entities. To systematically analyze MUC6 expression in normal and cancerous tissues, a tissue microarray containing 15 412 samples from 119 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. At least a weak MUC6 positivity was seen in 50 of 119 (42%) tumor entities. Thirty‐three tumor entities included tumors with strong positivity. MUC6 immunostaining was most frequent in mucinous carcinomas of the breast (44%), adenocarcinomas of the stomach (30%–40%) and esophagus (35%), and neuroendocrine carcinomas of the colon. Strong MUC6 staining was linked to advanced pT stage (p = 0.0464), defective mismatch repair status and right‐sided tumor location (p < 0.0001 each) in colorectal cancer, as well as to high tumor grade (p = 0.0291), nodal metastasis (p = 0.0485), erb‐b2 receptor tyrosine kinase 2 positivity (p < 0.0001) and negative estrogen receptor (p = 0.0332)/progesterone receptor (p = 0.0257) status in breast carcinomas of no special type. The broad range of tumor types with MUC6 expression limits the utility of MUC6 immunohistochemistry for the distinction of different tumor types.
Bank on it: Do Local Banks Contribute to Rural Community Prosperity?*
Authors: Mencken F. Carson , Carpenter Craig Wesley , Lotspeich‐Yadao Michael , Tolbert Charles M. 
Published: April 2023

AbstractRecent research on the restructuring of the financial industry from local banks to interstate conglomerates has raised questions about the impact on nonmetropolitan economies. In this paper, we develop two competing hypotheses and scrutinize the impact of local bank concentration (percent banks that are locally headquartered) on four measures of economic growth from 1980 to 2010 in metropolitan, micropolitan, and non‐core Commuting Zones (CZs). We employ fixed effects panel regression models for the 1980–2010 time frame. We find that local bank concentration is positively related to business births and establishment dynamics in non‐core and micropolitan CZs. The effects of local banking on measures of income and wages fail to show consistent effects. There are no positive local banking concentration effects on economic growth in metropolitan CZs during this time frame. Implications for theory, research, and policy are discussed.