bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Importin-α–Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis
Authors: Empitu Maulana A. , Kikyo Mitsuhiro , Shirata Naritoshi , Yamada Hiroyuki , Makino Shin-ichi , Kadariswantiningsih Ika N. , Aizawa Masashi , Patrakka Jaakko , Nishimori Katsuhiko , Asanuma Katsuhiko 
Published: May 2023

Significance Statement
Nuclear translocation of dendrin is observed in injured podocytes, but the mechanism and its consequence are unknown. In nephropathy mouse models, dendrin ablation attenuates proteinuria, podocyte loss, and glomerulosclerosis. The nuclear translocation of dendrin promotes c-Jun N-terminal kinase phosphorylation in podocytes, altering focal adhesion and enhancing cell detachment–induced apoptosis. We identified mediation of dendrin nuclear translocation by nuclear localization signal 1 (NLS1) sequence and adaptor protein importin-α. Inhibition of importin-α prevents nuclear translocation of dendrin, decreases podocyte loss, and attenuates glomerulosclerosis in nephropathy models. Thus, inhibiting importin-α–mediated nuclear translocation of dendrin is a potential strategy to halt podocyte loss and glomerulosclerosis.

Background
Nuclear translocation of dendrin is observed in the glomeruli in numerous human renal diseases, but the mechanism remains unknown. This study investigated that mechanism and its consequence in podocytes.

Methods
The effect of dendrin deficiency was studied in adriamycin (ADR) nephropathy model and membrane-associated guanylate kinase inverted 2 (MAGI2) podocyte-specific knockout (MAGI2 podKO) mice. The mechanism and the effect of nuclear translocation of dendrin were studied in podocytes overexpressing full-length dendrin and nuclear localization signal 1–deleted dendrin. Ivermectin was used to inhibit importin-α.

Results
Dendrin ablation reduced albuminuria, podocyte loss, and glomerulosclerosis in ADR-induced nephropathy and MAGI2 podKO mice. Dendrin deficiency also prolonged the lifespan of MAGI2 podKO mice. Nuclear dendrin promoted c-Jun N-terminal kinase phosphorylation that subsequently altered focal adhesion, reducing cell attachment and enhancing apoptosis in cultured podocytes. Classical bipartite nuclear localization signal sequence and importin-α mediate nuclear translocation of dendrin. The inhibition of importin-α/β reduced dendrin nuclear translocation and apoptosis in vitro as well as albuminuria, podocyte loss, and glomerulosclerosis in ADR-induced nephropathy and MAGI2 podKO mice. Importin-α3 colocalized with nuclear dendrin in the glomeruli of FSGS and IgA nephropathy patients.

Conclusions
Nuclear translocation of dendrin promotes cell detachment–induced apoptosis in podocytes. Therefore, inhibiting importin-α–mediated dendrin nuclear translocation is a potential strategy to prevent podocyte loss and glomerulosclerosis.
GELENEĞİN YENİDEN KEŞFİ: GÜMÜŞHANE ÖRNEĞİ ÇERÇEVESİNDE ZİYARET YERLERİNİN HASTALIKLARIN TEDAVİSİNDEKİ İŞLEVİ
Authors: YILDIRMIŞ Fatma 
Published: May 2023

Zengin bir muhtevayla günümüze kadar gelmiş tedavi yöntemlerini içeren Türk halk hekimliğinin tedavi yöntemlerinden biri ziyaret yerlerine giderek şifa aramaktır. Bütün Türk toplumlarında kutsallığına ve sağaltıcı gücüne inanılan ziyaret yerleri, geçmişte bir tedavi merkezi olarak işlev görmüştür. Oralarda dua etmek, adak adamak, kurban kesmek, mum yakmak, para atmak, bazen bir gece orada uyumak tedavi için uygulanan pratiklerdir. Bu ziyaret yerleri içinde hastalıklara iyi geldiğine inanılan türbeler, yatırlar, su gözeleri, mağaralar, ağaçlar, taşlar, kayalar, tepeler mevcuttur. Anadolu toprakları bu açıdan zengin bir birikime sahiptir.
Halk hekimliği uygulamaları, onları uygulayan insanların ekonomik ve sosyal şartlarının değişmesi ve modern tıbbın gelişmesiyle ikinci plana atılmıştır. Fakat geleneksel tıbba olan ihtiyaç tekrar artınca geleneğin yeniden keşfi gündeme gelmiştir. Bu makalede örneklem olarak Gümüşhane ve ilçeleri seçilmiş, örneklem içerisindeki ziyaret yerleri tespit edilerek hangi hastalığa tedavi olarak hangilerinin tercih edildiği incelenmiştir. Makalede gözlem, görüşme, kılavuz ve kaynak kişilerden bilgi toplama yöntemleri ve literatür taraması kullanılmıştır.
OSMANLI DÖNEMİNDE KARADENİZ ŞEHİRLERİNDE SİGORTALI İŞLEMLER VE SİGORTA ŞİRKETLERİNİN AKTİVİTELERİ
Authors: ÖZGER Yunus 
Published: May 2023

Dünyada sigortacılık, uluslararası ticaretle paralel gelişim gösterdi. İlk olarak liman şehirlerinde ortaya çıktı daha sonra iç bölgelerdeki şehirlere de yayıldı. Sigortacılığın Türkiye’deki gelişimi de aynıdır. Kapalı bir iç deniz olan Karadeniz, 1774 tarihli Küçük Kaynarca Antlaşması sonrasında ticari yönden ivme kazandı. Bölgede artan ticaret, sigortacılığı da beraberinde getirdi. Osmanlı coğrafyasında sigortacılığa rağbet, 1853-1856 Kırım Savaşı sonrasında arttı. Ancak bu tarihten önce de deniz nakliyatında sigortalı işlemlere tesadüf edilmektedir. Karadeniz’de en eski tarihli sigortalı nakliyat işlemi şimdilik 1789 tarihlidir.
Bu çalışmada Samsun, Trabzon, Sinop, Ordu gibi denize kıyısı olanlarla birlikte Amasya ve Tokat gibi iç bölgelerdeki Karadeniz şehirlerinde sigortacılık faaliyetleri incelendi. Bu bağlamda bölgede işlem yapan yabancı sigorta şirketleri hakkında bilgi verildi. Sigorta şirketlerinin bölgedeki rekabetleri konusu ele alındı. Bölgede kamuya ait yapıların sigortalanma süreçleri üzerinde duruldu. Kasıtlı yangınlar ve bunların sigorta şirketleriyle bağlantısı iddiaları ele alındı.
Effect of Metformin Monotherapy and Combination Therapy with Glimepiride on Lipid Profile in Drug Naive Type-2 Diabetes Patients: A Prospective Observational Study
Authors: Anchit  , Bhushan Aruna , B Srinivasa 
Published: May 2023

Background: Dyslipidemia is an important risk factor for development of macrovascular disease. Altered lipid metabolism and abnormality in serum lipid profile results atherogenic dyslipidemia this can worsen the prognosis of diabetic patients and increases risk of cardiovascular disease and stroke. This study aims to evaluate the effect of metformin monotherapy and combination therapy with glimepiride on lipid profile of drug naive type-2 diabetes patients after 10-12 weeks of treatment.
Methods: In this study, prescriptions of 120 OPD (Outpatient department) patients of drug naive type-2 diabetes were collected. The detailed observation of: demographic, drug details and investigations done were noted in a specially designed preform. The data was analyzed statistically and results were expressed as numbers and percentage.
Results: The total of 120 patients prescriptions was analyzed. Among these male was 62.5% and female were 37.5%, most common affected age group was between 31-50 years with mean age of 43.82 yrs. Metformin was most commonly prescribed drug 42% followed by its combination with glimepiride 58%. Average blood glucose level prior therapy was 193.4mg/dl and post therapy it was 135.2mg/dl. After 10-12 weeks of metformin monotherapy and combination therapy with glimepiride LDL was significantly reduced from 92.3mg/dl to 83.2mg/dl, TG was reduced from 145.5mg/dl to 132 mg/dl and HDL increased from 29.1 mg/dl to 32.9 mg/dl.
Conclusion: Metformin monotherapy and combination therapy with glimepiride appreciably improved dyslipidemia in drug naive type-2 diabetes patients.
Ventricular Fibrillation in Acute Coronary Syndrome with Elevated ST Segment: Incidence and Predictive Factors.
Authors: ZOUZOU Hanane 
Published: May 2023

Background: Ventricular fibrillation is the principal cause of sudden cardiac death; in acute coronary syndrome (ACS) with elevated ST segment, its incidence and predictive factors, have been the subject of several international studies; however, its epidemiological data is lacking in Algeria.
Aims: The main objective of our study is the determination of the frequency of ventricular fibrillation in acute coronary syndrome with elevated ST segment, the secondary objective was the analysis of predictive factors of this arrhythmia, and related mortality.
Methods and materials: In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached for continuous ECG monitoring during 48 hours
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results: The frequency of ventricular fibrillation is 5.8% (27 patients), CI 95%: [3.7%-7.9%], multivariate analysis identified the following independent predictors: low diastolic blood pressure: high ST segment elevation, large diastolic left and right ventricular diameters.
The risk of mortality expressed by Hazard Ration (HR) is 12.9 (CI 95%: [4.9-34], p < 0.001), the predictors of mortality are right ventricular failure and failure of thrombolysis.
Conclusion: Ventricular fibrillation is the principal cause of sudden cardiac death, during acute coronary syndrome with elevated ST segment, its predictive factors according to our study are: low diastolic blood pressure: high ST segment elevation, large diastolic left and right ventricular diameters, its occurrence increases the risk of hospital mortality, this high risk is partly explained by the therapeutic strategy.
Reflexiones desde el psicoanálisis a los retos ambientales de hoy. A propósito del libro "Desafíos y perspectivas de la situación ambiental en el Perú"
Authors: Hernández Camarero Max 
Published: May 2023

A propósito del libro Desafíos y perspectivas de la situación ambiental en el Perú: en el marco de la conmemoración de los 200 años de vida republicana, Augusto Castro y María Isabel Merino Gómez (editores), publicado por el INTE-PUCP, el artículo presenta los aportes de diversos autores que, desde el punto de vista social y psicoanalítico abordan los desafíos del cambio climático. Retomando las palabras de Sally Weintrobe, afrontar el cambio climático, no es un problema técnico o científico, es un problema humano y para abordarlo es necesario tomar en cuenta las variables psicológicas individuales y comunitarias.
Penyelesaian Sistem Persamaan Hukum Laju Reaksi dengan Metode Transformasi Differensial
Authors: Maftuhah Siti , Widayani Heni , Kusumastuti Ari 
Published: May 2023

This research is focused on solving the rate law equation by using the differential transformation method. The rate law equation describes the chemical reaction problem from the concentration of a reactant that produces a product. The differential transformation method is a semi-analytic numerical method that can provide approximate solutions in the form of a series because the method is obtained from the expansion of the Taylor series expansion. With the help of Maple software, a comparison of the solution plots of y_1 (t),y_2 (t) and y_3 (t), can be observed that the difference in computational results between the Runge-kutta method and the differential transformation depends on the order of k. The curve of the differential transformation method is getting closer to the curve of the Runge-Kutta method at a certain value of k for each y_1 (t),y_2 (t) and y_3 (t). The conclusion of this research is that the application of the differential transformation method has been successfully carried out in the case of a system of ordinary differential equations. For further research, the researcher suggests that the next research applies the method of differential transformation in cases and initial values that are more varied.
Cotas Raciais: caminhos abertos entre o “facão” e o “bisturi”
Authors: Silva Vera Regina Rodrigues da 
Published: May 2023

In the early 2000s, the debates and clashes over the adoption of affirmative actions, especially through the reservation of vacancies for the black population, the so-called racial quotas, strained the academic scenario. In this article, I use the memory of my academic trajectory from student to university professor during the process of discussion and implementation of racial quotas in Brazil to highlight facts and debates on the topic in focus. In the period between 2000-2012, I will name it as the open path “to the machete” in favor of racial quotas, in which the intensification and polarization contrary to the discussion were felt, as well as the confrontation with the adverse context. From 2012 to the present, I will name it the “scalpel” moment in which the affirmative action policy has legal support and effectiveness in Brazilian society, but it is still fought by its detractors.
The Risk of Nerve Injury in Pediatric Forearm Fractures
Authors: Zilliacus Kaj , Nietosvaara Yrjänä , Helenius Ilkka , Laaksonen Topi , Ahonen Matti , Grahn Petra 
Published: May 2023

Update
This article was updated on July 19, 2023, because of a previous error, which was discovered after the preliminary version of the article was posted online. On page 1080, in the last sentence of the Results section of the Abstract, the text that had read “0.05% (4 of 777)” now reads “0.5% (4 of 777).”

Background:
The risk of fracture-related nerve injury associated with forearm fractures in children is unknown. The purposes of the present study were to calculate the risk of fracture-related nerve injury and to report the institutional rate of complications of surgical treatment of pediatric forearm fractures.

Methods:
Four thousand, eight hundred and sixty-eight forearm fractures (ICD-10 codes S52.0 to S52.7) that had been treated in our tertiary level pediatric hospital between 2014 and 2021 were identified in our institutional fracture registry. Of these, 3,029 fractures occurred in boys and 53 were open fractures. Sex, age at injury, trauma mechanism and energy, fracture type, treatment method, and cause and type of nerve injury were assessed in 43 patients with 44 registered nerve injuries. Patients with nerve injuries were reevaluated to calculate the recovery time. Univariable and multivariable regression analyses were performed to determine the risk of nerve injury.

Results:
The risk of a fracture-related nerve injury was 0.7% (33 of 4,868). Only 2 injuries were permanent; thus, the risk of permanent nerve injury associated with a forearm fracture was 0.04% (2 of 4,868). The ulnar nerve was affected in 19 cases; the median nerve, in 8; and the radial nerve, in 7. In cases of open fracture, the risk of nerve injury was 17% (9 of 53). Open fractures had an OR of 33.73 (95% CI, 14.97 to 70.68) on univariate analysis and an OR of 10.73 (95% CI 4.50 to 24.22) on multivariate analysis with adjustment for female sex and both-bone diaphyseal fracture. Both-bone diaphyseal fracture (ICD-10 code S52.4) had an OR of 9.01 (95% CI, 4.86 to 17.37) on univariate analysis and an OR of 9.98 (95% CI 5.32 to 19.47) on multivariate analysis with adjustment for age and female sex. Overall, 777 fractures were internally fixed. The risk of nerve injury as a complication of internal fixation was 1.3% (10 of 777). Four of these iatrogenic injuries (including 2 involving the median nerve, 1 involving the ulnar nerve, and 1 involving the radial nerve) were permanent; thus, the risk of permanent nerve injury as a complication of internal fixation was 0.5% (4 of 777).

Conclusions:
Nerve injury following a pediatric forearm fracture is rare and has an excellent potential for spontaneous recovery. In the present study, all of the permanent nerve injuries occurred in association with open fractures or as a complication of internal fixation.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
UNLOCKING THE ARCHITECTURE OF THE COLONIZATION WINDOW: ICHNOFABRICS FROM UPPER CRETACEOUS TIDE-INFLUENCED MEANDER-LOOP DEPOSITS
Authors: DÍEZ-CANSECO DAVINIA , BUATOIS LUIS A. , MÁNGANO M. GABRIELA , CUEVAS-GONZÁLEZ JAIME , BENITO M. ISABEL 
Published: May 2023

ABSTRACTStudies dealing with the colonization window typically emphasize two major features: duration (short term vs. long term) and frequency of colonization (episodic vs. continuous). However, our understanding of tide-influenced meander loops requires consideration of an additional feature, the architecture of the colonization window, which comprises not only the spatial dimension and geometry of the colonization surface, but also its evolution through time. Tide-influenced meander-loop systems show a heterogeneous trace-fossil distribution that reflects the variety of processes operating along the point-bar and overbank colonization surfaces. Ichnofabric analysis of tide-influenced meander-loop deposits from the Upper Cretaceous Tremp Formation (Pyrenees, Spain) provides valuable insights into the sedimentary and ichnological dynamics of these marginal-marine systems and allows the importance of stratal geometry controlling the colonization window to be evaluated. Six ichnofabrics are identified in point bars and associated overbank deposits. These ichnofabrics differ in bioturbation index (e.g., higher in the upper part than the lower-middle parts of point bars), preservation of primary sedimentary fabric (typically preserved in the lower-middle parts of point bars), inferred behavior and trophic types (e.g., dominance of dwelling or feeding structures in the lower-middle and upper parts of point bars, respectively), and other features such as depth of penetration, ichnotaxonomic composition, presence or absence of root trace fossils and/or mottling, or number of superimposed suites. The key environmental factor controlling the nature and distribution of ichnofabrics is the morphology of the point-bar lateral-accretion surfaces and their evolution through time. The architecture of the colonization window is here linked to the helicoidal flow and discharge changes in meandering channels, and the successive development of lateral accretion units with time.
Bipolar valued probabilistic hesitant fuzzy sets based on Generalized Hybrid Operators in multi-criteria decision making problems based TOPSIS
Authors: özlü şerif 
Published: May 2023

Abstract
This paper aims to present some novel ordering methods to obtained Bipolar valued probabilistic hesitant fuzzy sets (BVPHFS) by extending probabilistic hesitant fuzzy sets (PHFS). PHFS is a strong version of hesitant fuzzy sets (HFS) in terms of evaluated as probabilistic of each element in HFS. Thus, this case proposes flexibility about selection of an element and aids to overcome with noise channels. Then, some properties of BVPHFS are surveyed. Further, some new aggregation operators are discussed called bipolar valued probabilistic hesitant fuzzy weighted average operator (BVPHFWA), Generalized bipolar valued probabilistic hesitant fuzzy weighted average operator (GBVPHFWA), bipolar valued probabilistic hesitant fuzzy weighted geometric operator (BVPHFWG), Generalized bipolar valued probabilistic hesitant fuzzy weighted geometric operator (GBVPHFWG), bipolar valued probabilistic hesitant fuzzy hybrid weighted arithmetic and geometric operator (BVPHFHWAG) and Generalized bipolar valued probabilistic hesitant fuzzy hybrid weighted arithmetic and geometric (GBVPHFHWAG) and some basic properties are presented. Moreover, two different algorithms are put forward with helping to TOPSIS method and by using aggregation operators over BVPHFSs. The validity of proposed operators are analyzed by proposing an example and results are compared in
their own.
Multiple Hypoxia-Independent Triggers of Upper Airway Long-Term Facilitation
Authors: Lui Simon , Tadjali Arash , Peever John 
Published: May 2023

Abstract

The respiratory control system can augment respiratory output following repetitive challenges. For example, repeated airway obstructions can trigger a form of respiratory memory that strengthens inspiratory activity of hypoglossal (XII) motoneurons. This augmentation in respiratory motor output is known as long-term facilitation (LTF) and can be elicited by repeated apneas or bouts of hypoxia. We demonstrate that LTF can be triggered in the absence of repeated apneas or hypoxia by intermittently stimulating locus coeruleus (LC) neurons, or through pharmacological activation of the neurotrophic machinery in XII motoneurons. We used pharmacological and optogenetic approaches to elicit LTF and show that this is mediated by α1-adrenergic receptor-binding at the XII motor pool. We also use optical LC inhibition to reaffirm the importance of the LC in mediating apnea-induced LTF. Lastly, we show that neurotrophic signaling agonists or antagonists applied to XII motoneurons can also be used to elicit or prevent LTF expression, respectively, and acts co-operatively with noradrenaline. These results suggest LTF can be triggered by multiple hypoxia-independent triggers and is mediated by the release of noradrenaline from the LC onto α1-adrenergic receptors on XII motoneurons to trigger plasticity via activation of neurotrophic signaling cascades.
Use of Routine Health Information Systems Data in Developing and Monitoring District and Facility Health Plans: A scoping review
Authors: Byrne Elaine , Heywood Arthur 
Published: May 2023

Abstract
Background:
Routine Health Information Systems data should be used in a systematic and institutionalised manner to support the making of plans, the monitoring of plans and in supportive supervision. To explore to what extent there is discussion about the linkage between planning, monitoring and supervision of sub-national programs using routine data we conducted a scoping review. The review question was: How are routine health information systems used or should be used in developing and monitoring health plans at district and facility level?
Methods:
From a search of Ovid Medline (all), EMBASE and Web of Science along with a review of grey literature and involving a number of key stakeholders in reviewing and identifying any missing resources a total of over 2200 documents were reviewed and data from 13 documents were extracted.
Results:
Overall, there are many descriptions of how to implement and strengthen systems, ways to assess and improve data availability and quality, tools to improve the data use context, training in data use and mechanisms to involve stakeholders and strengthen infrastructure. However, there are massive gaps in relation to good use cases or examples of where routine health data is used in the development, monitoring and supervision of plans at district and facility level.
Conclusions:
There appears to be no institutionalised obligation of planners to monitor plans, very little guidance on how to practically monitor programs and minimal discussion about how to use the routinely available data to supportively supervise the implementation of the plans.
To overcome these shortcomings, we recommend that practical procedures to ensure linkage of existing district plans to regular monitoring of priority programs are institutionalised, that mechanisms for making managers institutionally accountable for monitoring and supervising these plans are put in place, and that practical guidelines for linking plans with RHIS data and regular monitoring and supportive supervision are developed.