bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical Evaluation of Eco-friendly Designed Nonionic Sugar-based
Surfactants
Authors: Rastegar Fatemi Seyedeh Encieh , Shafiei Hadi , Mojtahedi Mohammad Majid 
Published: August 2023

Abstract:
This study deals with the density functional theory calculations of eco-friendly designed
nonionic sugar-based surfactants (SurfRing and SurfLinear). Then, it compares the results with the structural
and electronic properties of a fatty alcohol surfactant (SurfFA). All geometry optimizations and energy
calculations were performed using M06-2X functional and 6-31G(d,p) basis sets. The quantum chemistry
reactivity parameters showed the effect of hydrophilic fragment structure on intramolecular interactions
and conformational stability of surfactants. The results showed that SurfRing is more reactive than
SurfFA. Based on Bader’s quantum theory of atoms in molecules (QTAIM), one intramolecular hydrogen
bond (O43…H67―O57, EHB: -11.9 kcal.mol-1) is characterized for SurfRing, while two hydrogen bond
interactions (O63…H60―O59 and O65…H64―O63 with EHB of -13.0, and -12.3 kcal.mol-1, respectively)
form between the hydroxyl groups of SurfLinear. These intramolecular hydrogen bonds are partially
covalent interactions. Natural bond orbital analysis reveals that the most prominent interaction energy is
electron donation from the oxygen atom lone pair to the antibonding orbital of the O―H bond supporting
the results obtained from the AIM calculations.
Steroid as a Saviour and Culprit in Pemphigus Vulgaris Therapy: A Rare
Case Series
Authors: Avvaru Deepthi , Chaudhary Raushan Kumar , Doshi Bhavana , Bhandari Ramesh 
Published: August 2023

Introduction:
Pemphigus is a group of autoimmune dermatological life-threatening diseases
of which Pemphigus Vulgaris (PV) is the most common (1-5 cases/million/year) with a mortality rate
of 60-90%. PV is generally characterized by painful oral erosions, along with or without cutaneous lesions,
as blisters are often misdiagnosed. The management strategy of PV includes steroids along with
adjuvant therapy.

Case Presentation:
We report the case of three female patients with a mean age of 30.67 years who
were diagnosed with pemphigus vulgaris and was on steroid therapy for a long duration. The longterm
steroid therapy in all these three patients resulted in adverse drug reactions such as Cushing syndrome,
oral and vaginal candidiasis. Although the steroid was found to cause ADR among these patients,
the treatment with steroids and rituximab was continued. The withdrawal of steroids results in
flare-up conditions, whereas the addition of rituximab serves as a steroid sparring partner in the management
of PV. However, premedication was administered before the infusion of rituximab to prevent
potential toxicity associated with rituximab. Further, administration of pulse therapy over oral dosing
of steroids lowers the risks of ADR and long-term complications associated with steroids.

Conclusion:
As PV requires the management with high doses of steroids along with the immunosuppressant,
patients are more prone to developing drug-related problems. Hence, the rigorous monitoring
of the therapy is vital to prevent adverse effects of long-term therapy. Clinical pharmacists and pharmacologists
are the most suitable pillar of the healthcare system for drug therapy management.
Ethnomedicinal Importance of Patuletin in Medicine: Pharmacological
Activities and Analytical Aspects
Authors: Patel Dinesh Kumar , Singh Gireesh Kumar , Husain Gulam Mohammed , Prasad Satyendra K. 
Published: August 2023

Background:
Plant-derived bioactive molecules have been a major source of therapeutic agents for human and veterinarian purposes. Different traditional medicine system across the globe had relied on natural resources to meet their demand of healthcare. Still in modern world, pharmaceutical industries look for phytochemicals to develop new drugs. The current review explores patuletin, a flavonoid for its diverse reported pharmacological activities along with its analytical techniques.

Methods:
Scientific data published on patuletin was collected from Scopus, Science Direct, Pubmed, Google, and Google Scholar. The collected data were analyzed and arranged as per specific pharmacological activities performed using in-vitro or in-vivo methods. Analytical methods of patuletin have been presented next to pharmacological activities

Results:
Available scientific literature indicates patuletin has anti-inflammatory, cytotoxic, genotoxic, hepa-toprotective, antiproliferative, antiplatelet, antinociceptive, and antioxidant activity. In addition to these ac-tivities, its biological potential on breast cancer, rheumatoid arthritis, aldose reductase, and different types of microorganisms has been also presented in this work. Analytical data on patuletin signified the im-portance of patuletin for the standardization of herbal products and derived medicine.

Conclusion:
It may be concluded that patuletin with its diverse biological activities and readily available analytical methods, holds the potential to be translated into a new drug entity.
Quantitative Characterization of the Effect of Biogenic silver-based
Nanoparticles on Breast Cancer Cells by High Content Analysis
Authors: Ferreira Veronica , Eugenio Mateus , Del Nery Elaine , de Souza Wanderley , Sant’Anna Celso 
Published: August 2023

Background:
Among the various types of cancer, breast cancer is the most incident among
women. Due to the resistance to antitumor treatments, alternative treatments have been sought, such as
metallic nanoparticles.

Objective:
This study aimed to evaluate the antitumor potential and cytotoxicity induction mechanisms
of green synthesized AgCl-NPs and Ag/AgCl-NPs.

Methods:
The antitumor potential of nanoparticles was evaluated in breast cancer BT-474 and MDAMB-
436 cell lines treated with 0-40 μg/mL AgCl-NPs or 0-12.5 μg/mL Ag/AgCl-NPs through imagebased
high content analysis method. Normal human retinal pigment epithelial 1 (RPE-1) cells were
used for comparison.

Results:
The growth rate of the RPE-1 cells treated with nanoparticles was insignificantly affected,
and no significant changes in cell viability were observed. In these cells, the nanoparticle treatments
did not induce lysosomal damage, changes in ROS production, or reduction in the mitochondrial
membrane potential. The level of BT-474 and MDA-MB-436 cell proliferation was markedly decreased,
and cell viability was reduced by 64.19 and 46.19% after treatment with AgCl-NPs and reduced
by 98.36 and 82.29% after treatment with Ag/AgCl-NPs. The cells also showed a significant increase
in ROS production and loss of mitochondrial membrane potential, which culminated in an increase
in the percentage of apoptotic cells. BT-474 cells also presented lysosomal damage when
treated with the highest concentrations of both nanoparticle types and actin polymerization was observed
after exposure to Ag/AgCl-NPs.

Conclusions:
Together, the results showed overall cytotoxic effects of both AgCl-NPs and Ag/AgCl-
NPs towards breast cancer cells with negligible effects against healthy cells, which suggests their
promising anticancer and biomedical applications.
Recent Advances in Various Inorganic Nanoparticle Embedded
Chitosan-based Multifunctional Materials for Wound Healing
Authors: Bhattacharya Dipsikha , Ray Lipika , Pramanik Panchanan , Pandey Jitendra Kumar 
Published: August 2023

Abstract:
Scarless wound management remains a clinical challenge worldwide because of its com-plicated and overlapping phases of inflammation, clearing, and regeneration. Among the currently available dressing materials, hydrogels have attracted emerging attention as potential wound dress-ing materials because of their specific properties, such as porosity, tissue-mimicking architecture, softness, and improved mechanical, biological as well as physicochemical properties. However, naturally driven hydrogels have shown several advantages over conventional hydrogels because of their biodegradability, biocompatibility, high mechanical strength, and functionality. Recently, na-noparticle (NPs) integrated polymeric hydrogels (metals, non-metals, metal oxides, and polymeric moieties) have been established as analogous to these naturally driven hydrogels because of the synergistic effects of the NPs and polymers in the three-dimensional composite material. Over the years, researchers have reported the synthesis and potential applications of diverse inorganic and organic nanocomposite gels with antioxidant or antibacterial properties where they have exploited the intelligent incorporation of biomolecules into the NP-polymeric network that are beneficial for wound healing. Among various natural polymers as hydrogel matrix, chitosan-mediated hydrogel dressings have received extensive interest resulting in improved mechanical, biological, and physi-cochemical properties due to the well-reported antibacterial, antitumor, antioxidant, and tissue re-generation efficacies of chitosan polymer. This review is intended to summarize the recent devel-opments of inorganic nanoparticle-incorporated chitosan-based hydrogels as wound dressing mate-rials where various synthetic methodologies of these nanocomposite gels are extensively discussed via incorporating nanoparticles, active biomolecules, and other substances into the intrinsic struc-ture of the gels. In addition, the future and prospects of chitosan-based nanocomposite hydrogels as a novel wound dressing as well as tissue engineering materials are also highlighted.
Experience and Impact of COVID-19 on a Newly Formed Rural University Medical Office: Survey Study
Authors: Benton Mark 
Published: August 2023

Background
The COVID-19 pandemic had large social effects, particularly in the fields of medicine and medical education. Medical organizations in the United States operate in overlapping contexts with interrelated goals inside multiple organizations, and the context of work strongly influenced how organizations were able to respond to COVID-19 restrictions.

Objective
This research examines the experience and impact of COVID-19 on the implementation of a Health Resources and Services Administration grant in a newly formed university medical office with the interrelated goals of health policy, health outreach, and medical education. The goal is to understand how COVID-19 created different experiences and challenges for leaders and their collaborators working in medical education compared to those working in public health outreach or health policy.

Methods
A survey about COVID-19 opportunities and challenges was administered to work unit leaders and their project collaborators. The most common experiences and challenges are shown, direct educational and other respondents’ experiences and challenges are compared, and open-ended comment segments are analyzed.

Results
Helping others adjust to digital work, remoteness, and coordination were common experiences during COVID-19. Common challenges include coordination and an inability to make comparisons to previous program years. On average, respondents had 11.3 (SD 7.8) experiences and 8.3 (SD 6.9) challenges considered in the survey. While all units were influenced by COVID-19 restrictions, medical education units had more experiences and challenges. Those involved directly in medical education experienced 69% (18.6/27) of their possible experiences and 54% (14.7/27) of their possible challenges on average compared to 35% (7/20) and 21% (4.2/20) among other respondents (P<.001). COVID-19 restrictions increased the complexity of project work and presented challenges, especially in terms of coordinating responses and access to locations.

Conclusions
The findings suggest that COVID-19 made the overall administration of programs more complex and drew attention from other medical and public health programs. While remoteness is appropriate for some medical education tasks, it is less appropriate for clinical learning. Remoteness presents an especially large challenge to clinical education. Employees now have expectations for remoteness to be built into programs and workplaces. Program administrators will have to integrate remoteness’ benefits and drawbacks into their organization for the foreseeable future.
Physical Properties of Polyvinyl Alcohol/Chitosan Films with the Addition of Anthocyanin Extract from Butterfly Pea for Food Packaging Applications
Authors: Khanifah Siti , Legowo Alda Dwi Karina , Sholihun Sholihun , Nugraheni Ari Dwi 
Published: August 2023

Composites of polyvinyl alcohol (PVA) and chitosan (CH) polymers, with the addition of anthocyanin (AN) obtained from the butterfly pea flower, were prepared using drop-casting. The composites were made by adding different concentrations of 5–40% anthocyanin with 5 wt.% PVA and 2 wt.% CH solutions (weight ratio of PVA/CH is 80:20). These polymers solution was mixed at 80 °C and dried using the drop-casting method at 25 °C for 48 h. The composites were characterized using a scanning electron microscope (SEM), Fourier-transform infrared (FTIR), ultraviolet-visible (UV–vis spectroscopy), contact angle, antibacterial properties, and food packaging applications. The morphology obtained using an SEM showed that the PVA/CH surface with AN and glycerol was smoother than that of PVA/CH. The increased absorption at a wavelength of 650–700 nm from UV-vis spectroscopy confirmed the success addition of AN. The contact angles of PVA/CH/AN and PVA/CH/GS/AN films were 15°–66°, which showed that the films were hydrophilic. The simple antibacterial test with Escherichia coli and Staphylococcus aureus showed 16 mm inhibition zone by adding AN. The test results of these characteristics show the potential for using PVA/CH/AN and PVA/CH/GS/AN composite film to be used as an excellent development food packaging material.
Performance Assessment: Influence of Sorbate-Sorbent Interphase Using Magnetite Modified Graphene Oxide to Improve Wastewater Treatment
Authors: Oluwasina Olayinka Oluwaseun , Fahmi Mochamad Zakki , Oluwasina Olugbenga Oludayo 
Published: August 2023

The adsorption of brilliant green onto magnetite-graphene oxide nanoparticles (MGONPs) from an aqueous solution was explored via batch experiments. The adsorption properties of MGONPs were carried out under various experimental conditions related to pH, contact time, adsorbent dose, temperature, and initial adsorbate concentration. The adsorption capacity of MGONPs and optimum pH were 54.57 mg g−1 and 6, respectively. Equilibrium was attained after 30 min, and the adsorption kinetics data best fitted the pseudo-second-order. The Freundlich isotherm best fits the equilibrium. Acetone was able to desorb the dye from the loaded adsorbent. Additionally, the newly developed adsorption attributes effective surface area (eSBET) and dimensionless preferential adsorption (qp) were more accurate than the conventional specific surface area (SBET). The adsorption capacity provides information about the sorbate-sorbent interface (q). The relevance and accuracy of the new parameters for future adsorption system design by correlation analysis were validated. This study confirms the successful modification of MGONPs for the sorption of the cationic dye brilliant green.
Simple Microfluidic Paper-Based Analytical Device (μ-PAD) Coupled with Smartphone for Mn(II) Detection Using Tannin as a Green Reagent
Authors: Nitti Fidelis , Ati Wendelina Archangela , De Rozari Philiphi , Ola Pius Dore , Tambaru David , Kadang Luther 
Published: August 2023

The development of a simple yet greener microfluidic paper-based analytical device (μ-PAD) for on-site detection of Mn(II) in various types of waters using tannin as a natural reagent was described. The μ-PAD consists of twelve detection zones, created on a Whatman Number 1 filter paper by a simple drawing technique using an acrylic watercolor. The detection of Mn(II) was based on the color change on the reaction zone due to the reaction between Mn(II) and the pre-deposited tannin. The μ-PAD image was captured by a portable smartphone detector, and the blue intensity was digitized using a color picker application to generate the reflectance as the analytical response. The proposed method was characterized by a linear dynamic range of 0.05–0.25 mg L−1 with the limit of detection (LOD) for the determination of Mn(II) of 0.026 mg L−1. The other analytical merits of the proposed method, such as precision (RSD, 1.107%), accuracy (E, 6.697%), and recovery (104–112%), were all comparable to the existing spectrophotometric methods. The method’s successful application to natural water samples from manganese mining sites aligns with the reference spectrophotometric method, indicating its good selectivity and accuracy without significant influence of commonly associated interfering ions.
A Sustainable synthesis, eco-safe approach efficiency and DFT study of novel 5,6,7,8-Tetrahyroquinazolin-2(1H)-one derivatives as antioxidant reagents
Authors: Kadhim Mohammed Abed , Fahmy Amin Farouk Mohamed , Zangana Emad Khelil Mohammed , Hassaballah Aya Ibrahim , Rizk Sameh Ahmed 
Published: August 2023

5,6,7,8-Tetrahydroquinazolin-2-(thio)-ones (THQ) fits the class of N-heterocycles as a structural core in numerous bioactive compounds. They promptly extended previous decades. They were significantly recognized in combinatorial chemistry and materials science to determine the drug discovery, antioxidants, and pharmaceuticals fields. In the present work, one-pot multicomponent sustainable synthesis of THQ with easily accessible starting materials, i.e., cyclohexanone, different aromatic aldehydes and (thio)urea, has been performed to determine the proposed Biginelli mechanism that is supported by DFT. It is found that the THQs are synthesized by a mechano-chemical (grinding) tool to achieve a yield of 85.2% within 3.5 min, i.e., YE (% yield/time) 24.34 differs from the conventional method in which lower % yield (YE = 0.72) of THQ was achieved. This confirmed that in the green chemistry principle, the determination of % yield according to saving reaction time must be considered. Moreover, DFT-based antioxidant properties of the THQ were also studied in which the most potent antioxidant compounds were 7b > 6d > 2f. Softness (σ, eV−1) and hardness (η, eV mol−1) can approve the soft molecule that stays more reactive as a result of decreasing the energy gap along heterocyclic with values 0.1491 > 0.1300 > 0.1168 eV−1 one-to-one with the efficiency of antioxidant.
Loss of Glomerular Permselectivity in Type 2 Diabetes Associates With Progression to Kidney Failure
Authors: Saulnier Pierre J. , Looker Helen C. , Layton Anita , Lemley Kevin V. , Nelson Robert G. , Bjornstad Petter 
Published: August 2023

We examined whether defects in glomerular size selectivity in type 2 diabetes are associated with progressive kidney disease. Glomerular filtration rate (GFR) and fractional clearances of dextrans of graded sizes were measured in 185 American Indians. The permselectivity model that best fit the dextran sieving data represented the glomerular capillary as being perforated by small restrictive pores and a parallel population of larger nonrestrictive pores characterized by ω0, the fraction of total filtrate volume passing through this shunt. The hazard ratio (HR) for kidney failure was expressed per 1-SD increase of ω0 by Cox regression after adjusting for age, sex, mean arterial pressure, HbA1c, GFR, and the urine albumin-to-creatinine ratio (ACR). Baseline mean ± SD age was 43 ± 10 years, HbA1c 8.9 ± 2.5%, GFR 147 ± 46 mL/min, and median (interquartile range) ACR 41 (11–230) mg/g. During a median follow-up of 17.7 years, 67 participants developed kidney failure. After adjustment, each 1-SD increment in ω0 was associated with a higher risk of kidney failure (HR 1.55 [95% CI 1.17, 2.05]). Enhanced transglomerular passage of test macromolecules was associated with progression to kidney failure, independent of albuminuria and GFR, suggesting that mechanisms associated with impaired glomerular permselectivity are important determinants of progressive kidney disease.

Article Highlights
”Att se till och vårda dessa små.” Missionsförbundets föreställningar om barndom under 1930- och 1940-talet
Authors: Norburg Ulrika 
Published: August 2023

Den här artikeln handlar om Missionsförbundets barnhem Drott och Granås under 1930- och 1940-talet.1 Barnhemmet skapades med syfte att ta hand om så kallade missionärsbarn vars föräldrar svarat ja på Guds kallelse att missionera och omvända icke-kristna människor i Afrika. Forskning om missionärsbarn är relativt begränsad, både internationellt och i Sverige. Dessa barn har betraktats som en subgrupp som ofta hamnat i skuggan av missionärernas religiösa och kulturella diskurs. I artikeln analyseras Missionsförbundets styrelseprotokoll, publikationer och brevväxlingar mellan barnhemmets föreståndare och missionärsbarnens föräldrar. Resultatet visar hur samfundets företrädare, barnhemmets föreståndare och barnens föräldrar konstruerade och upprätthöll missionärernas föräldraskap och familjerelationer via emotionella beskrivningar. Dessa legitimerade både missionärernas föräldraskap och den uppoffring som missionärsarbetet innebar. I takt med att samfundet uppmärksammar separationers konsekvenser och att det medicinska området gör framsteg, förändras också förhållningssättet till barnen. Det leder fram till en kompromisslösning som gör att samfundet inrättar ett alternativ till barnhemmet i missionslandet Kongo.
English abstract
“To look after and care for these little ones.” The Missionary Association’s ideas about childhood during the 1930s and 1940s
This article is about the Missionary Association’s orphanage Drott and Granås during the 1930s and 1940s. The orphanage was created with the aim of taking care of so-called missionary children whose parents answered yes to God’s call to carry out missions and convert non-Christian people in Africa. Research on missionary children is relatively limited, both internationally and in Sweden. They have been considered a subgroup that has often been overshadowed by the missionaries’ religious and cultural discourse. In the article, the Missionary Union’s board minutes, publications and correspondence between the orphanage director and the missionary children’s parents are analyzed. The results show how the representatives of the community, the director of the orphanage and the children’s parents constructed and maintained the missionaries’ parenting and family relationships via emotional descriptions. These legitimized both the missionaries’ parentage and the sacrifice that missionary work entailed. As the community draws attention to the consequences of separations and as the medical field makes progress, the approach to children also changes. It leads to a compromise solution which means that the community establishes an alternative to the orphanage in the mission country Congo.