bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic polymorphism of divalent metal transporter 1 gene intronic IVS4+44C/A in cadmium exposed population
Authors: parnmen Sittiporn , Nooron Nattakarn , Chonnakijkul Pornpanna , Sikaphan Sujitra , Polputpisatkul Dutsadee , Uttawichai Chutimon , Chankunasuka Rungsaeng , Phatsarapongkul Sriprapa , Thunkhamrak Chidkamon , Nitma Unchalee , Palakul Nisakorn , Rojanawiwat Archawin 
Published: September 2023

Abstract
Background Exposure to cadmium is associated with a wide range of diseases, often influenced by genetic polymorphisms. This study aimed to investigate the role of the divalent metal transporter 1 (DMT1) gene intronic IVS4 + 44C/A polymorphism in individuals aged 35–60 residing in cadmium-contaminated areas.Methods Blood samples were collected from 306 genetically unrelated individuals (158 females and 148 males). Urinary cadmium levels were measured as an indicator of cadmium exposure. Genotype frequencies were determined for the DMT1 IVS4 + 44C/A polymorphism.Results The geometric mean of urinary cadmium levels was significantly higher in females (4.03±4.15 µg/g creatinine) compared to males (2.62±2.73 µg/g creatinine). Remarkably, 85% of females and 66% of males exceeded the reference values for urinary cadmium concentration set by the German Human Biomonitoring (HBM) Commission (HBM I and II). Genotype frequencies were 65.4% homozygote typical (CC), 31.0% heterozygote (CA), and 3.6% homozygote atypical (AA). The C allele frequency was 80.9%, while the A allele frequency was 19.1%. Notably, the DMT1 IVS4 + 44C/A polymorphism significantly influenced urinary cadmium levels, with the CA genotype showing higher levels compared to CC and AA genotypes. Urinary cadmium levels were also statistically increased with the presence of the A allele (A+ = CA + AA) compared to its absence (A− = CC). Furthermore, the CC genotype was associated with the highest number of individuals exceeding urinary cadmium reference values for HBM I and II across all age groups.Conclusions This study indicates that the CA genotype may signify susceptibility to prolonged cadmium exposure, given its association with elevated urinary cadmium levels. Additional research is essential for a thorough grasp of the implications of DMT1 gene polymorphisms on health outcomes, and to establish monitoring measures for populations residing in cadmium-contaminated areas.
Off-pump coronary artery bypass graft surgery: Collaborative Targeted Maximum Likelihood Estimation
Authors: Mansournia Mohammad Ali , Adineh Hossein Ali , Hosseini Kaveh , Zareban Iraj 
Published: September 2023

Abstract
Background: There is some discrepancy about the superiority of the off-pump coronary artery bypass grafting surgery to the conventional cardiopulmonary bypass (on-pump). We aimed to estimate the ratio of mortality risk in the off-pump coronary bypass to the on-pump by a causal model known as Collaborative Targeted Maximum Likelihood Estimation.
Study design and method: The data of the Tehran Heart Cohort study from 2007 to 2020 was used and analyzed. A collaborative targeted maximum likelihood estimation and targeted maximum likelihood estimation were used to estimate an adjusted risk ratio for the minimum sufficient set of confounders in a sequential approach. The results of these methods were compared to the traditional ones.
Results: Among 24883 participants (73.6% male), 5566 patients died during 8.2, on average, years follow-up. The estimated relative risk (95% confidence intervals) by un-adjusted general linear model, propensity matching, targeted maximum likelihood estimation, and Collaborative Targeted Maximum Likelihood Estimation was 0.86 (0.78-0.95), 0.88(0.8-0.97), 0.88 (0.8-0.97), and 0.99 (0.98-1.01), respectively.
Conclusion: Our analysis revealed that both techniques of surgery are safe and equally effective and there is no significant difference regarding mortality risk between the two techniques.
Patient satisfaction analysis of robot-assisted minimally invasive adrenalectomy: A single-center retrospective study
Authors: Yao Xue , Luo Xiaoyan , Tai Yanghao , Wang Kang , Shang Jiwen 
Published: September 2023

Abstract
Objective: To compare the satisfaction of patients undergoing robot-assisted retroperitoneal laparoscopy adrenalectomy under the ambulatory mode and conventional mode.
Methods: Basic information and clinical data of patients who underwent robotic-assisted posterior laparoscopic adrenalectomy between June 2020 and June 2023 were queried from our case system. Use the Outpatient and Ambulatory Surgery Consumer Assessment of Healthcare Providers and Systems Survey (OAS CAHPS®) to investigate patient satisfaction with preoperative preparation, discharge counseling, postoperative instructions, postoperative pain, and satisfaction with nursing work. The stats R package was used to select the appropriate statistic for the statistics based on the characteristics of the data.
Results:A total of 311 patients who underwent robot-assisted posterior laparoscopic adrenalectomy were enrolled in our case system. There were no statistical differences between the two groups in gender, age, body mass index, ASA classification, laterality, maximum tumor diameter, type of resection, hormonal activity, disease type, pathological classification, duration of surgery, estimated intraoperative bleeding, postoperative complications and follow-up period were compared between the two groups of patients. There were no significant differences in preoperative preparation score, discharge counseling score, postoperative guidance score and nursing care satisfaction score (P>0.05). Postoperative hospitalization, peristalsis time, defecation time, time to first postoperative mobilization, duration of indwelling drain and hospitalization costs in patients in the ambulatory model group were significantly less than patients in the conventional model group (P<0.001). Patients in the ambulatory model group had significantly higher postoperative pain relief scores than patients in the conventional model group.
Conclusions: In conclusion, our data suggest that patient satisfaction is equal between the conventional and ambulatory mode of performing robotic-assisted adrenalectomy. Patient satisfaction was probably associated with shorter hospitalization days, adequate preoperative preparation and standardized, high-quality post-discharge information and guidance.
Spatialized PM 2.5 during Covid-19 Pandemic in Brazil’s most populous Southern City: Implications for Post-Pandemic Era
Authors: Costa Gabriela da , Pauliquevis Theotonio , Heise Eduardo F. J. , Potgieter-Vermaak Sanja , Godoi Ana Flávia Locateli , Yamamoto Carlos Itsuo I. , Santos-Silva Jéssica Caroline dos , Godoi Ricardo Henrique Moreton 
Published: September 2023

Abstract
Brazil has experienced one of the highest COVID-19 fatality rates globally. While numerous studies have explored the potential connection between air pollution, specifically fine particulate matter (PM2.5), and the exacerbation of SARS-CoV-2 infection, the majority of this research has been conducted in foreign regions—Europe, the United States, and China—correlating generalized pollution levels with health-related scopes. In this study, we aim to delve into the localized relationship between air pollution exposure and its health implications within a specific Brazilian municipality, focusing on COVID-19 susceptibility. Our investigation involves assessing pollution levels through spatial interpolation of in-situ PM2.5 measurements. A network of affordable sensors collected data across 9 regions in Curitiba, as well as its metropolitan counterpart, Araucaria. Our findings distinctly unveil a significant positive correlation (r up to 0.36, p-value < 0.01) between more polluted areas, even more pronounced during winter months (r up to 0.40, p-value < 0.05), with both COVID-19 mortality and incidence rates. This correlation gains added significance due to the intricate interplay between urban atmospheric pollution and regional human development indexs. Notably, heightened pollution aligns with industrial hubs and intensified vehicular activity. The spatial analysis performed in this study assumes a pivotal role by identifying priority regions that require targeted action post-COVID. By comprehending the localized dynamics between air pollution and its health repercussions, tailored strategies can be implemented to alleviate these effects and ensure the well-being of the public.
Shell size variation of pteropod Heliconoides inflatus as a proxy for carbonate saturation
Authors: E Sreevidya , L. Mascarenhas-Pereira M. B. , B Nagender Nath , AV Sijinkumar 
Published: September 2023

Abstract
The current study is an effort to understand the relationship between the average shell size of the pteropod species, Heliconoides inflatus as a metric for shell calcification using several cores collected from the northern Indian Ocean (NIO). The shell size variability and dissolution proxies provide in-life or post-depositional H. inflatus shell dissolution records. They can be utilized as biological indicators of aragonite saturation of the seawater column. The results suggest that the shell calcification rate of H. inflatus is controlled by atmospheric CO2 concentration and water column chemistry if the cores are above the aragonite lysocline (Aly). The variability in carbonate saturation can also be delineated using dissolution indicators such as the Limacina Dissolution Index (LDX) and fragmentation ratio (FR), given that the shells hadn’t experienced any breakage during post-depositional and sample processing. The results suggest that shell size and optimum growth conditions are directly related since larger shell sizes coincide with the least dissolved pteropod shells during lower atmospheric CO2 concentration periods. The surface water supersaturated with carbonate ions resulted in higher calcification rates, producing larger, thicker, and better-preserved shells. The calcification proxy complements the dissolution proxies and reveals that the most intense aragonite dissolution occurred during the Holocene and interstadials/interglacials. The severe aragonite dissolution during interglacial could be due to the CO32− undersaturated bottom waters. However, the shells have undergone preferential dissolution to smaller shells below the aragonite compensation depth (ACD), which is suggested by the highly dissolved shells and larger shells in the deep core samples.
Thin Film Structured Superior Anode Material Based N-Graphene Supported Coupled NiO/TiO2 Hollow Nanospheres and Their Cyclic Voltammetry Performance
Authors: Azis Thamrin , Ashari Lintan , Muzakkar Muhammad Zakir , Nurdin Muhammad , Mulkiyan Muhammad Zuhdi , Umar Akrajas Ali 
Published: September 2023

Abstract
In this research, we succeeded in designing a new strategy to synthesize a unique thin film structured of nitrogen doped graphene (NGr) composite combined with coupled NiO/TiO2 hollow nanospheres using a synergistic hydrothermal method. The NGr@NiO/TiO2 composite characteristics are demonstrated by several rational characterization techniques such as the morphological shape of NiO/TiO2 hollow nanospheres which are evenly distributed on the surface of N-graphene with particle distribution in the range 79.78-362.13 nm with an average diameter of 130 nm. In addition, the crystal structures of carbon from NGr, NiO, and TiO2 (anatase and rutile) have been confirmed and proven by spectra showing the presence of C-N stretching primary amides (1400 cm− 1), Ni-O stretching (700 cm− 1) and Ti-O-Ti bond (425 cm− 1), respectively. The electrochemical test was carried out by optimizing the performance of cyclic voltammetry (CV) through parameters such as the influence of composition, scan rate, and cycle with the best conditions, namely composite ratio 80:10:10 (wt%), scan rate 50 mV/s, condition stable cycle and also calculated the high specific capacity value of 839.83 F/g. Based on this, it is revealed that NGr@NiO/TiO2 composites can explore the potential and be fully applied in the development of alkaline metal ion (AIB) batteries such as Li/Na/K.
Insecticidal activity of Ageratina adenophora (Asteraceae) extract against Limax maximus (Mollusca, Limacidae) at different development stages and its chemical constituent analysis
Authors: Li Haojun , Zhao Runa , Pan Yingna , Tian Hui , Chen Wenlong 
Published: September 2023

Abstract
The great grey slug, Limax maximus is one of the common agricultural pests, which infesting the growing period of vegetables by making holes or lacerations in the leaves of vegetables, especially seedlings and tender leaves. To evaluate the insecticidal activity of Ageratina adenophora extract against slugs, the fecundity, growth, hatching rate, offspring survival rate, protective enzyme and detoxifying enzyme activity of slugs in different periods exposed to LC50 of the extract for two different time intervals (i.e., 24 h, 48 h), and extracts phytochemical variability were studied. The LC50 values of the A. adenophora extract against L. maximus was 35.9 mg/ml. This extract significantly reduced the hatching rate of eggs and the survival rate of offspring hatched from exposed eggs compared to the control, which exposed for 48 hours was lowest. The survival, growth, protective enzyme and detoxification enzyme activity of newly hatched and 40-day-old slugs decreased. In the A. adenophora extracts, tannins, flavonoids and saponins were identified, which may be beneficial in their biological effects. These results suggest that A. adenophora extract can be used as an alternative drug to kill slugs to effectively control the species.
Analyzing Aging Effects on SRAM PUFs: Implications for Security and Reliability
Authors: Bhatta Niraj Prasad , Singh Harshdeep , Amsaad Fathi 
Published: September 2023

Abstract
Impact of aging effects on Static Random-Access Memory Physical Unclonable Functions (SRAM PUFs) presents critical implications for security and reliability in modern hardware. Emerging as promising hardware-based security primitives, SRAM PUFs harness process variations in integrated circuits for secure key generation and device authentication. However, aging phenomena like Bias Temperature Instability (BTI) and Hot Carrier Injection (HCI) can potentially alter SRAM cell characteristics, compromising PUF responses. This study delves into the multifaceted challenges of aging-induced variations, exposing underlying security vulnerabilities and offering innovative strategies to mitigate risks. Examining reliability implications, it introduces mitigation techniques such as adaptive reconfiguration, error correction codes, and multi-modal PUFs to enhance the resilience of SRAM PUFs. The investigation concludes by mapping future research directions and prospects for improving SRAM PUF-based security solutions, in light of the complexities associated with semiconductor device aging.
Evaluation of microbial pollution, biofilm formation, and malodor generation in household washing machines in Wuxi, China
Authors: Wu Jianrong , Zhang Yifei , Cao Yunyi , Gao Minjie , Zhang Hongtao 
Published: September 2023

Abstract
Microbial contamination in household washing machines (WMs) often leads to the formation of stubborn stains and the generation of unpleasant odors. In this study, 16s RNA sequencing was employed to detect the microbiota in the rubber ring, drum wall, and drainage outlet of WMs. As a result, Sphingobium, Pseudomonas, and Acinetobacter were found to persist over extended periods of time. Additionally, the dominant fungi identified in WMs were Paraphoma, Knufia, and Cladophialophora. The composition of the biofilm varied among different locations within each WM, reflecting differences in microbial composition. One significant component contributing to the odors in WMs is dimethyl disulfide(DMDS, C2H6S2), which is produced by common bacteria isolated from these WMs. While silver ions exhibited good inhibitory effects on most microorganisms found in WMs, they did not have a noticeable killing effect on Pseudomonas putida and Meyerozyma guilliermondii. On the other hand, the use of isothiazolinone as a bacteriostatic agent proved effective in inhibiting the growth of all isolated strains from WMs. These findings provide valuable insights into the composition of contaminated microorganisms, biofilm formation, and effective bacteriostatic methods for cleaning household WMs.
Research on Special Additional Deduction of Individual Income Tax Based on Sensitivity Analysis
Authors: Song Jianqi 
Published: September 2023

Abstract
Before 2019, the method of individual income tax declaration in China was based on individuals and did not take family factors into account, which gradually highlighted its incompatibility with reality. In order to reflect the fairness of tax burden, starting from January 1, 2019, a special additional deduction was added to the personal income tax on the basis of a basic expense deduction of 5000 yuan per month, taking into account family factors such as child education and elderly care. On August 31, 2023, the State Council raised the special additional deduction standards for personal income tax on the care of infants and young children under the age of 3, child education, and support for the elderly. The adjusted deduction standards will be implemented from January 1, 2023. To this end, the author will draw on the advanced practices of the United States, Japan, and Hong Kong in the special additional deductions for personal income tax, and then use actual survey questionnaires to scientifically determine the scope and methods of deduction for special additional items such as supporting the elderly, children's education, serious illness medical care, and housing loans in personal income tax. At the end of the article, the author uses sensitivity analysis to analyze the impact of special additional deductions on personal income tax burden, The conclusion is that individual declaration on a household basis can effectively alleviate the pressure of China's individual income tax burden and narrow the per capita income gap.
Clinical Value of Multimodal imaging methods in the preoperative diagnosis of rotator cuff tears under arthroscopy
Authors: Zhu Wei , Zhang Qing , He Wei , Jiang Chao , Zuo Hua , Zong Yang , Luo Zhenyu , Qian Xiaoqin 
Published: September 2023

Abstract
Background:The current study aimed to evaluate the clinical value of conventional ultrasound(C-US),percutaneous ultrasound-guided subacromial bursography (PUSB), magnetic resonance imaging (MRI) and their combined imaging application in the preoperative arthroscopic diagnosis of rotator cuff tears(RCTs).
Methods:A total of 120 patients with suspected RCTs were included in this study. The cohort consisted of 38 males and 82 females participants, ranging in age from 14 to 77 years,with an average age of 56.9 ± 11.1 years.Prior to surgery, all patients underwent C-US, P-CEUS, and MRI. Subsequently, the imaging data were subjected to retrospective analysis. With shoulder arthroscopy as the "gold standard", the diagnostic efficacy of multimodal imaging methods for RCTs was assessed.
Results:The sensitivity, specificity and accuracy of C-US in the diagnosis of RCTs were 52%, 64% and 55%, For PUSB, specificity, specificity and accuracy in the diagnosis of RCTs were 90%, 80% and 88%, MRI, on the other hand, demonstrated a sensitivity of 91%, specificity of 84%, and accuracy of 90% in diagnosing RCTs. Notably, when the three imaging modalities were combined, the diagnostic performance significantly improved. The combined approach yielded a sensitivity of 99%, specificity of 92%, and accuracy of 97% in diagnosing RCTs, surpassing the performance of any single imaging method. These results highlight the enhanced diagnostic capability achieved through the utilization of multiple imaging modalities.
Conclusion:Multimodal imaging is of high diagnostic value in RCTs, and can accurately determine the location and degree of RCTs, which can be an important reference for improving arthroscopic surgery.
Evaluation of moisture-induced stresses in wood cross-sections determined with a time-dependent, plastic material model during long-time exposure
Authors: Pech Sebastian , Autengruber Maximilian , Lukacevic Markus , Lackner Roman , Füssl Josef 
Published: September 2023

Abstract
In recent years, the use of timber as a building material in larger construction applications such as multi-story buildings and bridges has increased. This requires a better understanding of the material to realize such constructions and design them more economically. However, accurate computational simulations of timber structures are challenging due to the complexity and inhomogeneity of this naturally grown material. It exhibits growth inhomogeneities such as knots and fiber deviations, orthotropic material behavior and moisture dependence of almost all physical parameters. Describing the creep response of wood under real climate conditions is particularly difficult. Changes in moisture content, plasticity and viscoelasticity affect moisture-induced stresses and potentially lead to cracks and structural damage. In this paper, we apply a material model that combines time and moisture-dependent behavior with multisurface plasticity to simulate cross-sections of different dimensions over a 14-month climate period. Our findings indicate that considering this long-term behavior has a minor impact on moisture-induced stresses during the drying period. However, during the wetting period, a purely linear elastic description of the material behavior of wood significantly overestimates tensile stresses within the cross-section, resulting in unrealistic predictions of wetting-induced fracture. Therefore, simulations during wetting periods require a sophisticated rheological model to properly reproduce the stress field.
Dynamic viscosity of blood serum determined using proton magnetic relaxation
Authors: Torres Yulianela Mengana , Guevara Manuel Arsenio Lores , Milán Hugo Ferrales , Beyries Lidia Clara Suárez , Rodríguez Samuel Jorge Rosales , Reyes Inocente Rodríguez , Naranjo Juan Carlos García , Geli Yamirka Alonso 
Published: September 2023

Abstract
An experimental procedure, based on proton magnetic relaxation, is presented to determine the absolute dynamic viscosity in blood serum (hS). The blood serum samples were obtained voluntary from whole blood of healthy individuals and patients, and processed by classical methods (centrifugation and decanting). The Carr-Purcell-Meiboon-Gill pulse sequence was employed to determine the transverse proton magnetic relaxation time (T2) in a Tecmag Magnetic Resonance console coupled to a magnet of 0. 095 T and the temperature of measurement was 293 K. A theoretical linear behavior of the transverse proton magnetic relaxation rate (1/T2) as a function of hS was obtained after the consideration of blood serum as an extremely diluted solution of albumin and globulins, and assuming a fast exchange of water molecules between the bound phase and the solvent. A value of hS= 1.29±0.07 mPa s was obtained in samples belonging to 20 voluntary healthy individuals, which statistically match with the value obtained using the Ostwald viscometer for the same samples (hS= 1.32±0.04 mPa s, P=0.104319>0.05, a=0.05). The potential medical utility of the presented proton magnetic resonance procedure was demonstrated in patients with Multiple Myeloma (24) and Sickle Cell Disease (34), in which hS resulted increased with values of 1.40±0.18 mPa s (P=0.0137509<0.05, a=0.05) and 1.36±0.10 mPa s (P=0.00809615<0.05, a=0.05) respectivelly.