bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Second Hyper-Zagreb Index and Coindex of Chemical Nano-structures in Drugs
Authors: Alsharafi Mohammed , Zeren Yusuf , Ahmed Haifa , Alameri Abdu 
Published: August 2023

Abstract
The various dendrimer nanoparticles have properties like multivalency, controlled size, and surface functionality that make them promising nanocarriers for targeted drug delivery and other applications in pharmaceutical sciences. The precise tunability of dendrimers is an advantage over other nanoparticles. The topological descriptors can be used to predict the physicochemical properties of dendrimers and optimize their branching pattern for specific applications. The second Hyper-Zagreb index and coindex were computed for various chemical structures, including dendrimers, to facilitate the correlation between their structure and biological activity. In this study, the second Hyper-Zagreb index and coindex were computed for various chemical structures, such as the molecular graph of poly(propyl) ether imine dendrimer P ET IM nanostar dendrimer (D3[p]), Polypropylenimine octaamine dendrimer (NS1[p]) and (NS2[p]), Polymer dendrimer (NS3[p]) and (NS5[p]), Fullerene dendrimer (NS4[p]), and other classes of dendrimers.
Intratumoral Heterogeneity of Ki67 Proliferation Index Outperforms Conventional Prognostic Factors in Hormone Receptor-Positive Breast Cancer
Authors: Zilenaite-Petrulaitiene Dovile , Rasmusson Allan , Besusparis Justinas , Valkiuniene Ruta Barbora , Augulis Renaldas , Laurinaviciene Aida , Plancoulaine Benoit , Petkevicius Linas , Laurinavicius Arvydas 
Published: August 2023

Abstract
Background Immunohistochemistry (IHC) for ER, PR, HER2, and Ki67 is used in breast cancer (BC) pathology to assess tumor properties and predict patient outcomes and therapy responses. Visual scoring of the IHC biomarkers by pathologists, apart from reproducibility issues, does not sufficiently account for the intratumoral heterogeneity (ITH), often a subvisual feature within the tumor tissue. It has been reported that the ITH indicators of IHC biomarker expression can provide independent prognostic value. In this study, we applied digital image analysis (DIA) and computational pathology methods to investigate the prognostic value of IHC ITH indicators in hormone receptor-positive (HR-positive) BC patients.Methods Whole slide images of surgically excised specimens stained for ER, PR, Ki67, and HER2 from 178 patients with a diagnosis of HR-positive invasive ductal carcinoma were used in the study. Digital tumor tissue segmentation and detection of biomarker-positive and negative cells were performed. The DIA-generated data were systematically subsampled by a hexagonal grid to compute Haralick’s texture indicators for ER, PR, Ki67, and HER2. Univariate and multivariable Cox regression analyses were performed to assess the prognostic significance of the IHC and ITH indicators in the context of clinicopathologic variables, including conventional assessment of the IHC results provided by pathologists.Results In multivariable analysis, the ITH of Ki67-positive cells, measured by Haralick’s texture entropy, emerged as an independent prognostic factor associated with worse overall survival (hazard ratio = 11.40, p-value = 0.021). Remarkably, the entropy representing the spatial disarrangement of tumor proliferation outperformed the proliferation rate per se established either by pathology reports or DIA. None of the clinicopathologic variables were selected as independent prognostic features in our dataset.Conclusions These results add to the evidence from previous studies that ITH of IHC biomarkers, in particular, ITH of Ki67 proliferation index, exceeds the informative value of Ki67% per se (both visual and digital) in HR-positive BC. The study further demonstrates the benefits of high-capacity DIA-generated data for quantifying the essentially subvisual ITH properties.
Occult Squamous Cell Carcinoma in Lichenoid Dermatitis of the Glans Penis: A Potentially Life Threatening Entity Identified by Immunohistochemistry
Authors: Alomary Simona , Shah Rohan , Bova Emma , Swearingen Alyssa , Schwartz Robert , Lambert W. Clark 
Published: August 2023

Abstract
We have recently reported a series of three cases initially diagnosed histopathologically as lichenoid dermatitis subsequently revealed to be occult squamous cell carcinoma using immunohistochemistry. We now report a fourth case in the glans penis.
MIMO antenna with UWB characteristics and sharp multi-stop band characteristics
Authors: Pannu Preeti 
Published: August 2023

Abstract

With multi-band rejection characteristics, a new low profile antenna of size 34x34 mm2 is conferred in this article. It consist of quad identical monopole elements (originated orthogonally), contributing ultra-wide band characteristics in the system. The single unit of the proposed design consists of modified spinning-top shape radiator (MSTSR), excited by tapered micro strip line feed (TMLF) and semi-circular ground. An excellent bandwidth of 3-12.9GHz (where S11<-10dB) is obtained at each port. By inserting structure of four spirals coils, a sharp notch ranges from 7.9- 8.5GHz is achieved to filter X-band satellite communication uplink. In addition, a circular spiral slot in radiator near the ground plane create stop band at 7.35- 7.565GHz band (satellite communication downlink band). Furthermore, symmetrical rectangular trapezoids resonators and inverted symmetrical rectangular trapezoid structures near the feed line are responsible for elimination of interferences at 5.5GHz lower WLAN and 3.5GHz WiMAX respectively. The FR-4 substrate used for UWB-MIMO design fabrication process and fabricated results are found in good match with the simulated results. Also, the design provides good performance metrics such as total active reflection coefficient, diversity gain, channel capacity loss, isolation, and envelope correlation coefficient.
Cytochrome b Gene as a potential DNA Barcoding Marker in ecoraces of Tropical Tasar Silkworm Antheraea mylitta Drury
Authors: Ray Priti Pragyan , Barala Barsha , Dash Purushottam 
Published: August 2023

Abstract

Background:
Tropical Tasar silkworm Antheraea mylitta Drury, from an economic prospect of view bears a very important role in development of rural community and tribal community of India, through silk production. Since the population of this species has spread over many states with varying environmental factors, the population has isolated into many pockets of population, specifically adapted to that niche, which are called “Ecoraces”. Even though phenotypically these ecoraces may look similar to some level but intra-specific genotypic variability between them affects the yield trait of their cocoons. The purpose of our study was to use Cyt- b gene of mitochondrial genome as a potential DNA barcoding marker for identification of these ecoraces, which is the first report for these ecoraces.
Methods and Results:
For the amplification of mitochondrial cytochrome b gene, 12s rRNA Specific Primer Cytb_mcb 398 and Cytb_mcb 869 were used. The Neighbour-Joining tree was generated using MEGAX with Kimura 2 Parameter molecular evolutionary model. Statistical support for the nodes and the internodes were calculated using bootstrap analysis with 1000 replicates. Maximum likelihood phylogeny analysis was carried out in MEGA X adjusted to 1000 bootstrap replicates under Tamura-3-Parameter. The strongness of the clade was assessed using bootstrap analysis. The parsimony tree was also created using the same MEGA X software. The genetic distance, gene flow and relation among the ecoraces was obtained.
Conclusion:
Apart from being used as an early-warning system for ecological degradation, this knowledge will help in assessing the evolutionary relationship of these economically important ecoraces and identify their position in the process of evolution aiding the assessment of conservation priorities.
High proportion of circulating CD38+ NK cells：a novel biomarker for lymph node metastasis and poor prognosis in colorectal cancer
Authors: Wang Xueling , Li Haoran , Chen Huixian , Fang Kehua , Chang Xiaotian 
Published: August 2023

Abstract
Background lymph node status is a critical prognostic factor for colorectal cancer (CRC). Due to the potential influence of immune system on CRC progression, investigation into lymphocyte subsets as clinical biomarkers has gained attention. The objective of this study was to assess the predictive capability of lymphocyte subsets for lymph node metastasis (LNM) and prognosis of CRC.Methods Lymphocyte subsets, including T cells (CD3+), natural killer cells (NK, CD3- CD56+), natural killer-like T cells (NKT-like, CD3 + CD56+), CD38 + NK cells (CD3- CD56 + CD38+) and CD38 + NKT-like cells (CD3 + CD56 + CD38+), were detected by flow cytometry. Univariate and multivariate analyses were used to assess the risk factors of LNM. The prognostic role of parameters was evaluated by survival analysis.Results The proportion of CD38 + NK cells within the NK cell population was significantly higher in LNM-positive patients (p < 0.001). However, no significant differences were observed in the proportions of other lymphocyte subsets. Poorer histologic grade (odds ratio [OR] = 3.78, p = 0.039), lymphovascular invasion (LVI) (OR = 24.52, p < 0.001), and CD38 + NK cells (high) (OR = 4.67, p < 0.001) were identified as independent risk factors for LNM. Furthermore, high proportion of CD38 + NK cells was associated with poor prognosis of CRC patients (HR = 2.37, p = 0.025).Conclusions The proportion of CD38 + NK cells within the NK cell population is a promising biomarker for LNM. Moreover, an elevated proportion of CD38 + NK cells is associated with poor prognosis in CRC.
Investigation on the impact of new bike stations on a bike-share system based on a complex bike-sharing network
Authors: Kim Kyoungok 
Published: August 2023

Abstract
The effect of newly introduced bike stations on bike-share systems at the system, community, and station levels is investigated in this study. Changes in the topological properties of a bike-share traffic network and its subnetworks defined through community detection are examined using a network analysis methodology that has been relatively underexplored in previous studies despite its significance and utility. Centrality and network flow measures are employed to assess the effects of new bike stations on both individual stations and communities. The findings reveal that introducing new bike stations significantly enhances station connectivity and overall bike usage. However, the impact varies across communities and existing bike stations; notably, spatial relationships with preexisting stations tend to diminish the influence of new stations. This study also establishes a correlation between the utilization of new bike stations and the centrality and network flow of existing neighboring stations.
Domain Generalization for Road Scene Object Detection under Different Weather Conditions
Authors: Wang Yunting , Zhang Jinyi , Jiang Yuxi 
Published: August 2023

Abstract

Road scene object detection is an important component in the field of intelligent transportation, which directly affects the implementation of numerous intelligent transportation applications. However, existing road scene object detection models, mostly developed based on clear weather conditions, are not effective in different weather conditions, and the corresponding detection accuracies will be drastically reduced. To address this problem, this paper proposes a domain generalization method for road scene object detection under different weather conditions. This method employs a road scene domain-invariant feature extraction network to extract both intra-domain and inter-domain invariant features from training domain images, and generates more diverse domain-invariant features for road scene under different weather conditions to enhance the generalization capability of the object detection model. Furthermore, an improved self-distillation mechanism is introduced for the feature extraction of the object detection model, so that the features extracted by the object detection model have rich domain-invariant information to further enhance its generalization ability, thus improving the detection accuracy of the object detection model. The experimental results show that the detection accuracy of the method in this paper is significantly improved compared with that of Faster R-CNN, with a 5.7% improvement in daytime-sunny scene, a 5.9% improvement in dusk-rainy scene, a 2.6% improvement in night-rainy scene, and a 4.7% improvement in daytime-foggy scene. Based on the research methodology presented in this paper, it provides effective support for the practical implementation of intelligent transportation technologies such as vehicle recognition and pedestrian detection.
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway
Authors: Wang XiaoChun , Li XiaoLi , Ma XueNi , Zhang LuDan , Han TiYun , Zhang DeKui 
Published: August 2023

Abstract

Objective: Intestinal fibrosis is a common complication of inflammatory bowel disease and is characterized by tissue stiffening and luminal narrowing. Dihydromyricetin (DHM) can alleviate liver fibrosis and renal interstitial fibrosis by inducing autophagy. However, whether DHM can alleviate intestinal fibrosis remains unclear. This study aimed to evaluate the role and mechanism of action of DHM in inflammatory bowel disease-associated intestinal fibrosis .
Methods: Mice were administered Dextran sulphate Sodium (DSS) in drinking water to induce inflammatory bowel disease-associated intestinal fibrosis. HE staining, qPCR and Western blotting were used to analyze colon inflammation. Masson’ s trichrome staining, qPCR, Western blotting and immunofluorescence staining were used to evaluate the severity of fibrosis. Transmission electron microscopy and Western blotting were used to assess the activation of autophagosomes. The human colonic fibroblast line CCD-18Co, was cultured in the presence of TGF-β1 to develop a fibrotic phenotype.Immunofluorescence staining, Western blotting and qPCR were used to assess the alteration of fibrosis markers and used to investigate whether DHM-induced autophagy was involved in the inactivation of CCD-18Co cells. Additionally, the role of the PI3K/AKT/mTOR pathway was investigated.
Results: DHM alleviated intestinal inflammation and inhibited the progression of intestinal fibrosis. Additionally, DHM induced the activation of autophagy, thereby alleviating intestinal fibrosis, and downregulated the PI3K/AKT/mTOR signaling pathway in vitro.
Conclusions: Overall, this study demonstrated that DHM can inhibit the progression of intestinal fibrosis and activation of colonic fibroblasts by inducing autophagy through the PI3K/AKT/mTOR signaling pathway, thereby playing a preventive and therapeutic role in intestinal fibrosis.
Enhancing PV System Grid Stability Through Reliable Flexible Power Point Tracking Under Partial Shading
Authors: Ouatman Hamid , Boutammachte Nour-Eddine , Tafti Hossein Dehghani , Ouqour Ahmed 
Published: August 2023

Abstract

Flexible power point tracking (FPPT) is incorporated in photovoltaic (PV) systems to enhance the quality and reliability of electricity generation while minimizing grid disruptions and overloads. Grid-friendly systems that contribute to grid control can be developed by modifying maximum power point tracking (MPPT) algorithms. However, the widely used perturb and observe (PO) method for FPPT (FPPT-PO) suffers from oscillations around steady-state operating points, which can be problematic. Moreover, solutions provided in previous studies on FPPT algorithms that address partial shading conditions (PSC) are limited. This study proposes a reliable and sustainable FPPT-PSO algorithm that utilizes the principles of particle swarm optimization (PSO). It involves a power limitation control approach that prevents oscillations at steady-state operating points under PSC and avoids being ensnared at a local maximum power point (MPP). Additionally, the suggested FPPT-PSO algorithm detects changes in power requirements or irradiation conditions. The proposed FPPT-PSO algorithm outperforms other state-of-the-art solutions under PSC, providing more precise PV system performance and avoiding grid disruption and overload. The suggested method is evaluated using MATLAB/Simulink and precise tracking of the global MPP is demonstrated. Drawing on the simulation outcomes, the proposed FPPT-PSO algorithm can perfectly follow the flexible power point (FPP) without fluctuating around a steady-state operating point under PSC.
FUNCTIONS, SLEEP, FATIGUE AND QUALITY OF LIFE IN PATIENTS WITH SCLERODERMA DURING COVID-19: CROSS - SECTIONAL STUDY
Authors: ÇİVİ KARAASLAN Tuğba , TARAKCI Ela , KELEŞ Özal , ASLAN KELEŞ Yasemin , UĞURLU Serdal 
Published: August 2023

Purpose: COVID-19, which has affected people in various ways, has also shown to cause various limitations on the lives of Scleroderma patients. The current study aims at evaluating the upper extremity functions, sleep quality, fatigue, and health-related quality of life in Scleroderma patients and to determine the factors affecting upper extremity functions.
Methods: A total of 83 participants were recruited in this study. Of the participants, 39 were Scleroderma patients (mean age 43.28±9.96 years) and 44 were healthy controls (mean age 40.05±8.89 years). The Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH) and Michigan Hand Outcomes Questionnaire (MHQ) were applied to evaluate upper extremity functions of the participants. Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), and the Scleroderma Health Assessment Questionnaire (SHAQ) were used to evaluate the sleep quality, fatigue, and health-related quality of life, respectively.
Results: Scleroderma patients had significantly lower scores in hand functions, sleep quality, fatigue, and health-related quality than the healthy group (p=0.001). The correlations between DASH and PSQI (r=0.559, p=0.001), FSS (r=0.496, p=0.001), SHAQ scores (r=0.754, p=0.001) were highly positive. Similarly, a high correlation was found between MHQ and SHAQ scores (r=-0.679, p=0.001).
Conclusion: Upper extremity functions and health-related quality of life were found to be affected in patients with Scleroderma. It was revealed that upper extremity functions were affected by sleep quality, fatigue, and health-related quality of life. Therefore, knowing all these effects and their relationships with each other allows to draw a systematic treatment plan on Scleroderma patients.
Identifying a Novel Eight-NK Cell-related Gene Signature for
Ovarian Cancer Prognosis Prediction
Authors: Li Nan , Yu Kai , Huang Delun , Zhou Hui , Zeng Dingyuan 
Published: August 2023

Background:
Ovarian cancer (OVC) is the most common and costly tumor in
the world with unfavorable overall survival and prognosis. This study is aimed to explore
the prognostic value of natural killer cells related genes for OVC treatment.

Methods:
RNA-seq and clinical information were acquired from the TCGA-OVC dataset
(training dataset) and the GSE51800 dataset (validation dataset). Genes linked to NK
cells were obtained from the immPort dataset. Moreover, ConsensusClusterPlus facilitated
the screening of molecular subtypes. Following this, the risk model was established
by LASSO analysis, and immune infiltration and immunotherapy were then detected by
CIBERSORT, ssGSEA, ESTIMATE, and TIDE algorithms.

Results:
Based on 23 NK cell-related genes with prognosis, TCGA-OVC samples were
classified into two clusters, namely C1 and C2. Of these, C1 had better survival outcomes
as well as enhanced immune infiltration and tumor stem cells. Additionally, it was
more suitable for immunotherapy and was also sensitive to traditional chemotherapy
drugs. The eight-gene prognosis model was constructed and verified via the GSE51800
dataset. Additionally, a high infiltration level of immune cells was observed in low-risk
patients. Low-risk samples also benefited from immunotherapy and chemotherapy drugs.
Finally, a nomogram and ROC curves were applied to validate model accuracy.

Conclusion:
The present study identified a RiskScore signature, which could stratify patients
with different infiltration levels, immunotherapy, and chemotherapy drugs. Our
study provided a basis for precisely evaluating OVC therapy and prognosis.
Preparation of Fluorous Aza-crown Ether with Two Bisfluorous Chain
Type Propionyl Groups: An Investigation of its Partition Ratios in
Fluorous Biphasic Systems and Recyclability During SN2-type
Acetoxylation Reactions
Authors: Yamanoi Takashi , Koike Kenji , Oda Yoshiki 
Published: August 2023

Abstract:
In this study, a new fluorous aza-crown ether derivative (1) conjugated with two Bfp
(bisfluorous chain type propionyl) groups was prepared; then, the partition ratios of 1 in biphasic systems
using FC 72 and several organic solvents were investigated. Next, the activities of 1 in an FC
72/acetonitrile biphasic system were assessed via the SN2-type acetoxylation reaction using 2-
(bromomethyl)naphthalene and potassium acetate. Finally, the recyclability of 1 in a two-layer system
based on its immobilization in an FC 72 solvent was examined during acetoxylation reactions.
Drug Targets, Current and Future Therapeutics for the Treatment of
Multi Drug Resistant Tuberculosis with their Clinical Applications: A
Critical Review
Authors: Singh Deepshikha , Singh Vikram , Mandal Subhankar P. , Dsouza Karen , Kumar B.R. Prashantha , Dixit Sheshagiri R. 
Published: August 2023

Abstract:
Multi drug-resistant or extensive drug resistance Mycobacterium tuberculosis poses numerous
challenges for health care workers and for public health authorities. Treating multidrug resistant or
extensive drug resistance tuberculosis continues to be a difficult task, as a longer regimen is associated
with a higher number of adverse drug events and economic burden and has a significant negative effect
on health care resources. Many trials and observational studies were conducted. Few studies are
underway to develop the universal regimen and improve the outcomes related to multi or extensive
drug resistance tuberculosis with a shorter regimen duration. The current review will discuss which
drug inhibits what target, their synthesis, genetic aspects, repurposed drugs, novel drugs, and extensive
trials for the treatment of multi or extensive drug resistance tuberculosis.