bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guideline adherence to statin therapy and association with short-term and long-term cardiac complications following noncardiac surgery
Authors: Glarner Noemi , Puelacher Christian , Gualandro Danielle Menosi , Lurati Buse Giovanna , Hidvegi Reka , Bolliger Daniel , Lampart Andreas , Burri Katrin , Pargger Mirjam , Gerhard Hatice , Weder Samantha , Maiorano Silvia , Meister Rebecca , Tschan Carla , Osswald Stefan , Steiner Luzius A. , Guerke Lorenz , Kappos Elisabeth A. , Clauss Martin , Filipovic Miodrag , Arenja Nisha , Mueller Christian 
Published: September 2023

BACKGROUND
Peri-operative complications are common and associated with high morbidity and mortality. Optimising the use of statins might be of important benefit in peri-operative care and reduce morbidity and mortality.

OBJECTIVE
To evaluate adherence to current guideline recommendations regarding statin therapy and its association with peri-operative and long-term cardiac complications.

DESIGN
Prospective cohort study.

SETTING
Multicentre study with enrolment from October 2014 to February 2018.

PATIENTS
Eight thousand one hundred and sixteen high-risk inpatients undergoing major noncardiac surgery who were eligible for the institutional peri-operative myocardial injury/infarction (PMI) active surveillance and response program.

MAIN OUTCOME MEASURES
Class I indications for statin therapy were derived from the current ESC Clinical Practice Guidelines during the time of enrolment. PMI was prospectively defined as an absolute increase in cTn concentration of the 99th percentile in healthy individuals above the preoperative concentration within the first three postoperative days. Long-term cardiac complications included cardiovascular death and spontaneous myocardial infarction (MI) within 120 days.

RESULTS
The mean age was 73.7 years; 45.2% were women. Four thousand two hundred and twenty-seven of 8116 patients (52.1%) had a class I indication for statin therapy. Of these, 2440 of 4227 patients (57.7%) were on statins preoperatively. Adherence to statins was lower in women than in men (46.9 versus 63.9%, P < 0.001). PMI due to type 1 myocardial infarction/injury (T1MI; n = 42), or likely type 2 MI (lT2MI; n = 466) occurred in 508 of 4170 (12.2%) patients. The weighted odds ratio in patients on statin therapy was 1.15 [95% confidence interval (CI) 1.01 to 1.31, P = 0.036]. During the 120-day follow-up, 192 patients (4.6%) suffered cardiovascular death and spontaneous MI. After multivariable adjustment, preoperative use of statins was associated with reduced risk; weighted hazard ratio 0.59 (95% CI 0.41 to 0.86, P = 0.006).

CONCLUSION
Adherence to guideline-recommended statin therapy was suboptimal, particularly in women. Statin use was associated with an increased risk of PMI due to T1MI and lT2MI but reduced risk of cardiovascular death and spontaneous MI within 120 days.

TRIAL REGISTRATION
Clinicaltrials.gov identifier NCT02573532
Assessment of explicit and implicit memories during remimazolam anaesthesia using the process dissociation procedure
Authors: Kim Kyung Mi , Bang Ji-Yeon , Choi Byung-Moon , Noh Gyu-Jeong 
Published: September 2023

BACKGROUND
Memory formation during remimazolam anaesthesia, where a bispectral index (BIS) is sometimes not maintained at less than 60 despite the maximal dose, is worthy of evaluation.

OBJECTIVE
Investigate the formation of explicit and implicit memories using the process dissociation procedure during remimazolam anaesthesia at a BIS of 60 to 80.

DESIGN
A prospective cohort study.

SETTING
A tertiary medical centre in Seoul, South Korea, between March 2022 and July 2022.

PATIENTS
One hundred patients undergoing general anaesthesia using remimazolam.

INTERVENTIONS
The BIS was maintained at 60 to 80 during anaesthesia induction with remimazolam. Words were spoken to patients via headphones for 15 min.

MAIN OUTCOME MEASURE
The primary outcome was the probability of explicit or implicit memory formation as calculated using the original and extended models, within 24 h after word presentation. Conscious recall memory was assessed using a short-structured interview within 1 and 24 h after surgery. Memory formation was inferred to be absent if 0 was included in the 95% confidence interval (CI) of the probability.

RESULTS
The main results showed no evidence of explicit or implicit memory. The 95% CI of the probability of explicit memory formation included 0 for both models, –0.01 (–0.04 to 0.02) and –0.04 (–0.10 to 0.01), respectively. The 95% CI of the probability of implicit memory formation did not include 0 when evaluated using the original model, 0.08 (0.06 to 0.10), but included 0 when evaluated using the extended model, 0.00 (–0.03 to 0.03). The modified Brice interview revealed no evidence of awareness.

CONCLUSIONS
There was no evidence of explicit or implicit memory formation during remimazolam anaesthesia (BIS 60 to 80). Further research is warranted to establish whether explicit and implicit memories are still absent even in the presence of surgical stimulation.

CLINICAL TRIAL REGISTRATION
KCT0006752 (http://cris.nih.go.kr)
Twitter Buzz and Citations: Who’s Tweeting Matters for Plastic Surgery Literature
Authors: Slovacek Cedar , Cook Tracey , Sheppard Acacia , Palacios Pablo , Bradley James P. , Chen Kevin C. 
Published: September 2023

Background:
Plastic surgery and social media have become inextricably linked through patient procurement, practice growth, and academic exposure. Other surgical fields have demonstrated that tweeting is positively correlated with increased citations. This study aimed to elucidate the effect of Twitter on traditional bibliometrics in plastic surgery and parse out the kinds of tweets that are most correlated with citations.

Methods:
Articles from May to October of 2018 from Plastic and Reconstructive Surgery and Aesthetic Surgery Journal were analyzed to determine the citation count, number and backgrounds of Twitter users tweeting about the article, and total tweets. Multiple linear regression was performed to correlate these variables to citation count.

Results:
A total of 369 articles were analyzed. Plastic and Reconstructive Surgery had significantly more average tweets per article compared to Aesthetic Surgery Journal (21.8 versus 10.2, P < 0.001), Additionally, a number of tweets (r = 0.45, P < 0.001) and reaching more total followers (r = 0.48, P < 0.001) were both positively correlated with citations. Multiple linear regression demonstrated that tweets from self-identified scientists were positively correlated with citations (r = 0.99, P = 0.001). Tweets from science communicators had no correlation with citations (r = −0.012, P = 0.726). Tweets coming domestically from the country of the author were also associated with more citations (r = 0.164, P = 0.013).

Conclusions:
Twitter activity, including the number of followers reached, for an article is positively correlated with citations. Interestingly, the kind of person tweeting affected the citations as well. Domestic tweets and those from scientists were associated with more citations. This implies that Twitter can be an effective form of academic dissemination, provided the “right” Twitter users are promoting the article.
Multi-Zonal Outer Retinopathy and Retinal Pigment Epitheliopathy (MORR). A Newly Recognized Entity or an Unusual Variant of AZOOR?
Authors: Ramtohul Prithvi , Marchese Alessandro , Introini Ugo , Goldstein Debra A. , Freund K. Bailey , Jampol Lee M. , Yannuzzi Lawrence A. 
Published: September 2023

Abstract

Purpose:
To describe specific clinical, multimodal imaging, and natural history features of an unusual variant of acute zonal occult outer retinopathy (AZOOR).

Methods:
Retrospective, observational, longitudinal, multi-center case series. Patients exhibiting this unusual clinical condition among cases previously diagnosed with AZOOR were included. Multimodal imaging, laboratory evaluations and genetic testing for inherited retinal diseases were reviewed.

Results:
Twenty eyes from 10 patients (8 females and 2 males) with a mean age of 54.1±13.3 years (range, 38-71 years) were included. The mean follow-up duration was 13.1±5.3 years (range, 8-23 years). Presenting symptoms were bilateral in 7 patients (85% of eyes) and included scotomata and photopsia. All patients had bilateral lesions at presentation involving the peripapillary and far peripheral retina. Baseline optical coherence tomography showed alteration of both the retinal pigment epithelium (RPE) and photoreceptor layers corresponding to zonal areas of fundus autofluorescence abnormalities. Centrifugal and centripetal progression of the peripapillary and far-peripheral lesions, respectively, occurred over the follow-up resulting in areas of complete outer retinal and RPE atrophy.

Conclusions:
Initial alteration of both photoreceptors and RPE and a stereotypical natural course, that includes involvement of the far retinal periphery, characterize this unusual condition. It may represent a variant of AZOOR or may be a new entity. We suggest to call it multizonal outer retinopathy and retinal pigment epitheliopathy (MORR).
Polypoidal Lesions Associated with Choroidal Nevi
Authors: Gomel Nir , Goldstein Michaella , Fung Adrian T. , Iovino Claudio , Tatti Filippo , Peiretti Enrico , Habot-Wilner Zohar , Loewenstein Anat , Iglicki Matias , Zur Dinah 
Published: September 2023

Abstract

Purpose:
To investigate eyes with polypoidal lesions associated with choroidal nevi, their multimodal imaging characteristics, and long clinical follow-up.

Methods:
Multicenter, retrospective case series study of patients with polypoidal lesions overlying choroidal nevi. Demographic and clinical information was recorded. Multimodal imaging including colour fundus photography (CFP), optical coherence tomography (OCT), OCT angiography, fundus fluorescein angiography (FA), indocyanine angiography (ICGA) and A- and B-scan ultrasonography were analyzed for nevus and polypoidal lesion characteristics.

Results:
Fourteen eyes (14 patients; mean age: 70.3±6.7 years) with polypoidal lesions overlying choroidal nevi were included. The mean follow-up duration was 50.0±27.9 months (range 12-108). All nevi were pigmented on CFP, flat on ultrasonography with a mean basal diameter of 3.8±0.4 mm. In all but one eye, OCT showed a shallow irregular pigment epithelium detachment (SIRE) overlying the nevus. A total of 11/14 eyes (78.6%) had exudative activity, 9 eyes received intravitreal anti-vascular endothelial growth factor (VEGF) injections, and one eye required intravitreal anti-VEGF combined with photodynamic therapy (PDT). Mean visual acuity was 20/32 at baseline and 20/50 at final visit.

Conclusions:
We present the largest known cohort of eyes with polypoidal lesions associated with choroidal nevi with up to 9 years follow-up. The exudative degree of the polypoidal lesion in this condition is variable and treatment decisions should be taken on an individual basis. We hypothesize that choroidal ischemia due to altered choroidal vasculature rather than Haller layer hyperpermeability plays a role in the formation of polypoidal lesions overlying nevi.
Impact of Methylprednisolone Pulse on the Mortality of Patients With Acute Respiratory Distress Syndrome Secondary to COVID-19
Authors: Sousa Adrián , Lima Olalla , Pérez-González Alexandre , Araujo Alejandro , Longueira Rebeca , Otero Antón , Núñez Marta , Ramos Cristina , Martínez-Lamas Lucía , Crespo-Casal Manuel , Rubianes Martin , Pérez-Rodríguez María Teresa 
Published: September 2023

Introduction
Corticosteroids have been thoroughly used in the treatment of COVID-19. The aim of the study was to analyze the impact of methylprednisolone pulse on in-hospital mortality of patients with acute respiratory distress syndrome (ARDS) due to COVID-19.

Methods
We conducted a retrospective, single-center observational study. We selected adult patients admitted to the hospital with the diagnosis of COVID-19 between March and June 2020. Cox regression was used to identify the factors associated with in-hospital mortality.

Results
A total of 306 patients were analyzed. In-hospital crude mortality rate was 17%. Diabetes mellitus (hazard ratio [HR], 5.5; 95% confidence interval [CI], 1.40–4.55), dementia (HR, 7.7; 95% CI, 4.25–13.87) and ARDS (HR, 4.2; 95% CI, 2.34–7.46) were associated with in-hospital mortality. In patients with ARDS diagnosis, the only in-hospital mortality risk factor was dementia (HR, 5.2; 95% CI, 2.44–11.07), whereas methylprednisolone pulse was a protective factor (HR, 0.2; 95% CI, 0.09–0.63). In the follow-up, 40% of patients had some symptom related to COVID-19.

Conclusions
Methylprednisolone pulse reduced the in-hospital mortality in patients with ARDS due to COVID-19. A high percentage of patients presented persistent symptoms in 90 days after the hospital discharge.
Effect of pelvic floor muscles exercises by extracorporeal magnetic innervations on the bladder neck and urinary symptoms
Authors: Chang Chieh-Yu , Tang Feng-Hsiang , Lin Kun-Ling , Liu Yi-Yin , Loo Zi-Xi , Long Cheng-Yu 
Published: September 2023

Background:
This study aimed to investigate the changes in the bladder neck (BN) and urinary symptoms using extracorporeal magnetic innervation (ExMI) therapy before and after performing passive pelvic floor exercises.

Methods:
Twenty women with stress urinary incontinence (SUI) were assessed by transperineal ultrasound and questionnaires before and after the ExMI therapy from January 2011 to February 2021.

Results:
The incidence of urinary frequency and SUI were significantly decreased after the therapy (McNemar test, p < 0.01). The therapeutic efficacy of SUI was 75%. A significant decrease was noted in pad test results (paired t test, p < 0.05). At the same time, there was a considerable difference in Urinary Distress Inventory-6 scale measures (paired t test, p < 0.001). However, results for the Incontinence Impact Questionnaire-7 showed a marginally significant difference (paired t test, p = 0.066). Three domains of lubrication, orgasm, and satisfaction in the Female Sexual Function Index showed significant differences (paired t test, p < 0.05). Transperineal ultrasound found that BN mobility and Q-tip straining angle were not statistically significant (paired t test, p > 0.05).

Conclusion:
The ExMI is effective for SUI by strengthening the pelvic floor muscle without significantly decreasing BN mobility.
We Have to Really Decide
Authors: Osteen Kathryn , Tucker Cheryl A. , Meraz Rebecca 
Published: September 2023

Background
Medical management and surgical improvement techniques permit persons with congenital heart conditions to live longer. Adults with congenital heart disease (CHD) have more childbearing options than previously available to them. However, there is an increased childbearing risk associated with certain types of CHD. Minimal investigation has been given to the childbearing decision-making experiences and adaptation of women with CHD.

Objective
The aim of this study was to gain insight into the childbearing decision-making and adaptation experiences of women with CHD.

Methods
Using a narrative inquiry approach, 17 adult women with CHD of any severity, of childbearing age, who had, within the last 5 years, made a decision regarding childbearing, were interviewed. In this study, we applied the key components of the Roy Adaptation Model to understand childbearing decision-making experiences and their adaptation. Data were analyzed using thematic analysis.

Results
Data analysis revealed 5 stages of childbearing decision making: (1) prologue: stimulus to consider childbearing; (2) exploring childbearing options; (3) considering childbearing options; (4) choosing to bear or not to bear a child; and (5) epilogue: adapting to the childbearing decision. Adaptation occurred in the areas of self-concept (ie, emotional adaptation), role function (ie, relational adaptation), and interdependence (ie, interactional adaptation).

Conclusion
Childbearing decision making is a complex personal decision that is carefully and deliberately made. Women with CHD long for children and seek childbearing information from various resources and may experience grief regarding the inability to bear children. A greater understanding of childbearing decision making can be useful in addressing women's childbearing emotions and assist with adaptation to childbearing needs.
Analgesic comparison of erector spinae plane block with intercostal nerve block for thoracoscopic surgery: A meta-analysis of randomized controlled trials
Authors: Ma Guineng , Gou Jiwei , Chen Limimg , Qiao Xiaojian 
Published: September 2023

Introduction:
The analgesic efficacy of erector spinae plane block (ESPB) versus intercostal nerve block (ICNB) for thoracoscopic surgery remains controversial. We conducted a systematic review and meta-analysis to explore the impact of ESPB versus ICNB on thoracoscopic surgery.

Methods:
We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through May 2023 for randomized controlled trials (RCTs) assessing the effect of ESPB versus ICNB on thoracoscopic surgery. This meta-analysis was performed using the random-effect model or fixed-effect model based on the heterogeneity.

Results:
Four RCTs and 203 patients are included in the meta-analysis. Overall, compared with ICNB for thoracoscopic surgery, ESPB results in significantly reduced pain scores at 48 hours (SMD [standard mean difference] = −3.49; 95% CI [confidence interval] = −6.76 to −0.21; P = .04), but demonstrated no impact on pain scores at 24 hours (SMD = −0.04; 95% CI = −1.24 to 1.16; P = .95), pain scores at 4 to 6 hours (SMD = −0.16; 95% CI = −2.02 to 1.71; P = .87), pain scores at 12 hours (SMD = −0.16; 95% CI = −2.38 to 2.05; P = .88) or analgesic consumption (SMD = 0.27; 95% CI = −0.80 to 1.35; P = .62).

Conclusions:
ESPB may be comparable with ICNB for the postoperative pain control of thoracoscopic surgery.
Hypertonic glucose in the treatment of low back pain: A randomized clinical trial
Authors: Pereira Pires Jose Alberto , Rey Moura Ed Carlos , Oliveira Caio Marcio Barros de , Vieira Dibai-Filho Almir , Soares Brandão Nascimento Maria do Desterro , da Cunha Leal Plinio 
Published: September 2023

Background:
Chronic low back pain (LBP) is defined as pain lasting longer than 3 months and is one of the conditions with the most significant social impact. Treatment is complex and includes proliferative agents used in prolotherapy. The mechanism is not known, but osmotic agents (hypertonic solutions of dextrose or glucose) cause cellular rupture and an inflammatory response that releases cytokines and growth factors that lead to scarring and reinnervation.

Methods:
Patients with chronic LBP (>12 weeks) who were non-traumatic and unresponsive to at least 1 month of physical therapy were selected. All patients were followed up at a return visit at 1, 3, and 6 months for pain assessment using validated pain questionnaires and scales.

Results:
Nineteen patients were included in the conservative group and 19 in the glucose group, with the majority being women (57.9%). The patients were between 47 and 59 years of age (39.5%), mixed race (76.33%), married or in a committed relationship (73.7%), and had completed the study for 5.2 years. Overall mean body mass index was 27.3 ± 4.4 kg/m2 and was higher in the conservative group (28.0 ± 4.7 kg/m2). The groups showed differences in Visual Analog Scale scores, with median and amplitude values close to each other between the time points evaluated and increasing values in the glucose group, which had significantly higher values for this scale at the third evaluation (P = .031). When comparing the Rolland-Morris scale scores between the groups, there was a significant difference only in the 3-m assessment (P = .021). In the follow-up assessment, both groups showed significant improvement between T0 and the other assessment time points (P < .05) in all evaluations.

Conclusion:
Both groups significantly improved on the evaluated scales during follow-up. Overall, no effects were attributable to the glucose components or the prolotherapy protocol.
Treatment of glenohumeral internal rotation deficit in the general population with shoulder pain: An open single-arm clinical trial
Authors: Jácome-López Rafael , Tejada-Gallego Javier , Silberberg José María , García-Sanz Fernando , García-Muro San José Francisco 
Published: September 2023

Background:
Maladaptation can provoke important alterations in the arthrokinematics such as an internal rotation reduction in the dominant shoulder compared with the nondominant shoulder known as glenohumeral internal rotation deficit (GIRD). Though the number of studies investigating GIRD in athletic population, there are not studies reporting the efficacy of the GIRD treatment in the nonathlete population, a kind of study required to improve our understanding of patient care with this pathology. This study aimed to describe the efficacy of the GIRD treatment in nonathlete population with shoulder pain.

Methods:
An open single-arm trial with 35 patients was adopted for evaluating the efficacy of GIRD treatment in patients with shoulder pain. All patients with shoulder pain who attended the consultation, accepted, and agreed to participate in the study between October 2020 and March 2021 were included. A treatment sequence including joint manual therapy techniques and soft tissue release techniques was applied in the consultation. Then, patients were instructed to adapt the daily active biological stimulus at home. The IR before (IR0) and after (IR1) the treatment was considered the outcome measure. The GIRD was calculated as the difference between the IR of the non-painful shoulder and the IR of the painful shoulder before (GIRD0) and after treatment (GIRD1). A paired Student t test was used to compare the GIRD of each patient before and after the treatment.

Results:
Treatment of the patients significantly increased the IR of the painful shoulder in all the patients (P-value < .0001) So, the mean IR0 was 26.09 ± 14.46º (23.64–28.53), and after the treatment the mean IR1 was 67.98 ± 15.03º (65.48–70.52). The mean difference after the treatment (IR1–IR0) was 41.89 ± 14.74º (39.4–44.39). The treatment also significantly reduced GIRD (P-value < .0001). So, the mean GIRD0 was 42.95 ± 16.26º (40.2–45.7), and after the treatment the mean GIRD1 was –1.05 ± 17.18º (–3.96 to 1.85).

Conclusions:
The treatment administrated in this study significantly increased the internal rotation of the treated and painful shoulder and reduced the GIRD from the first consultation.

Level of evidence:
Level 3.