bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legibility: knowing disability in medical education inclusion
Authors: Jain Neera R. 
Published: July 2023

AbstractHow medical students, their teachers, and school administrators understand disability appears connected to ongoing, unequal access to medical education for disabled people. The stigmatization of disability within medical education affects students’ disability disclosures, yet few studies have explored how understandings of disability influence inclusion practices beyond individual student actions. This paper develops the concept of legibility, derived from a constructivist grounded theory study that examined disability inclusion at four U.S. medical schools through interviews with 19 disabled students and 27 school officials (faculty and administrators). With two dimensions (recognition and assessment of possibility), legibility demonstrates that knowing disability is relational, contextual, and equivocal. Drawing from the field of disability studies, the paper argues that the current paradigm of disability inclusion demands that students’ disability experiences be highly legible to themselves and others, yet increased legibility comes with potential risk due to prevalent ableism. While individual interactions can shift understandings of disability towards greater inclusivity, systemic action that embeds liberating discourses of disability into medical education is needed.
Green innovation, firm performance, and risk mitigation: evidence from the USA
Authors: Liu Lewis 
Published: July 2023

AbstractThis research examines the correlation between corporate green innovation and its positive impacts by analyzing firm-level data from the S&P 500 spanning the years 2001 to 2022. Drawing on previous studies, this research employs rigorous methodologies and measures to assess the influence of green innovation. The study investigates the drivers of green innovation and assesses its potential effects on firm performance and risk reduction. Firstly, it explores the factors that contribute to the adoption of green innovation. Secondly, it examines how green innovation affects firm performance and mitigates risks. The findings of the study demonstrate that implementing green innovation leads to a reduction in firm volatility and credit risk, while also enhancing firm value and emission performance. The robustness tests conducted further reinforce these conclusions, thereby contributing to the existing body of literature that highlights the crucial role of corporate characteristics in promoting sustainable business practices through green innovation. These insights hold significant value for investors, policymakers, and regulators, providing them with valuable information for making informed decisions regarding green investments and the formulation of policies that foster sustainability through green innovation.
Untangling Biocultural and Socioeconomical Drivers of African Plum Tree (Dacryodes edulis) Local Nomenclature Along a Rural-Urban Gradient in Central Cameroon
Authors: Lemoine Taïna , Rimlinger Aurore , Duminil Jérôme , Leclerc Christian , Labeyrie Vanesse , Tsogo Mélanie , Carrière Stéphanie M. 
Published: July 2023

AbstractIn Cameroon, the African plum tree (Dacryodes edulis [G. Don] H. J. Lam) is widely cultivated for its fruits, which contribute significantly to household food security and economy. In order to analyze the links between the social and ecological systems that result in the remarkable fruit diversity, we focused on how the important varietal diversity of African plums was perceived and named by tree owners. We conducted semi‑structured interviews in Center-Cameroon with 142 people belonging to the Beti ethnic group, in urban (Yaoundé), peri-urban and rural areas, and analyzed the data qualitatively and quantitatively. Along this urbanization gradient linking production to consumption regions, 158 different translated names were recorded. Most names (80%) were cited once, but some names based on fruit size and taste were common across the gradient. Although the highest total number of names was recorded in the rural site, many different names were also found along the urban–rural gradient. We did not detect difference in the number of named African plums between respondents with different characteristics. The local classification of African plums among the Beti was structured predominantly according to morphological and organoleptic criteria, but also to symbolic and practical criteria. African plums’ names were based on people’s fruit preferences, that favor large, oily, and blue to black fruits, and disregard pink-colored watery plums. This study is an entry point to explore the rising trade and thus ongoing domestication of the African plum tree from an often neglected perspective, that of local nomenclature.
Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation
Authors: Meyer Benedikt J , Kunz Natalia , Seki Sayuri , Higgins Rebecca , Ghosh Adhideb , Hupfer Robin , Baldrich Adrian , Hirsiger Julia R , Jauch Annaïse J , Burgener Anne-Valérie , Lötscher Jonas , Aschwanden Markus , Dickenmann Michael , Stegert Mihaela , Berger Christoph T , Daikeler Thomas , Heijnen Ingmar , Navarini Alexander A , Rudin Christoph , Yamamoto Hiroyuki , Kemper Claudia , Hess Christoph , Recher Mike 
Published: July 2023

AbstractMutations in CD46 predispose to atypical hemolytic uremic syndrome (aHUS) with low penetrance. Factors driving immune-dysregulatory disease in individual mutation carriers have remained ill-understood. In addition to its role as a negative regulator of the complement system, CD46 modifies T cell-intrinsic metabolic adaptation and cytokine production. Comparative immunologic analysis of diseased vs. healthy CD46 mutation carriers has not been performed in detail yet. In this study, we comprehensively analyzed clinical, molecular, immune-phenotypic, cytokine secretion, immune-metabolic, and genetic profiles in healthy vs. diseased individuals carrying a rare, heterozygous CD46 mutation identified within a large single family. Five out of six studied individuals carried a CD46 gene splice-site mutation causing an in-frame deletion of 21 base pairs. One child suffered from aHUS and his paternal uncle manifested with adult-onset systemic lupus erythematosus (SLE). Three mutation carriers had no clinical evidence of CD46-related disease to date. CD4+ T cell-intrinsic CD46 expression was uniformly 50%-reduced but was comparable in diseased vs. healthy mutation carriers. Reconstitution experiments defined the 21-base pair-deleted CD46 variant as intracellularly—but not surface-expressed and haploinsufficient. Both healthy and diseased mutation carriers displayed reduced CD46-dependent T cell mitochondrial adaptation. Diseased mutation carriers had lower peripheral regulatory T cell (Treg) frequencies and carried potentially epistatic, private rare variants in other inborn errors of immunity (IEI)-associated proinflammatory genes, not found in healthy mutation carriers. In conclusion, low Treg and rare non-CD46 immune-gene variants may contribute to clinically manifest CD46 haploinsufficiency-associated immune-dysregulation.
Strengthening the System Supporting Perinatal People with Substance Use Disorder in the Midwest Using Group Model Building
Authors: Simon Jessica , Guynn Isabella , Thompson Meagan , Hambright Sarah , Jones Cresta , Lich Kristen Hassmiller 
Published: July 2023

Abstract
Introduction
Providing comprehensive, evidence-based care to perinatal people with substance use disorders (SUD) requires multi-stakeholder collaboration and alignment. The National Maternal and Child Health Workforce Development Center facilitated a system-strengthening process with the Midwest substance use in pregnancy (SUPper) club, a regional collaborative of health care providers, state public health agencies, and community-rooted organizations.

Methods
Facilitators led a 2 day group model building (GMB) workshop with 20 participants and two semi-structured interviews. Workshop participants were invited to complete an evaluation.

Results
Two primary trends were identified as priorities for change: (1) Birthing people’s perception/experience of stigma and (2) The Midwest SUPper Club’s reach and influence. Three causal loop diagrams (CLDs) were created to capture the interconnected dynamics of the Midwest perinatal SUD system: (1) the influence of stigma on maternal and infant health outcomes, (2) the role of clinic, organizational, and state policies, and (3) the impact of workforce education and evidence-based practices on care. From the CLDs, four priorities for action emerged: (1) align and promote shared mental models across stakeholders, (2) expand education and training opportunities for the perinatal SUD workforce, (3) strengthen systems infrastructure to support care navigation for patients and providers, and (4) collaboratively identify evidence-based practices that meet regional needs. All evaluation respondents reported that the workshop supported the development of a shared mental model.

Discussion
The GMB process strengthened collaboration and advanced strategic planning for the SUPper Club. GMB can be further utilized among diverse stakeholders across MCH systems to create shared mental models and accelerate collaborative planning efforts.
Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis
Authors: Layer Julian P. , Hamed Motaz , Potthoff Anna-Laura , Dejonckheere Cas S. , Layer Katharina , Sarria Gustavo R. , Scafa Davide , Koch David , Köksal Mümtaz , Kugel Fabian , Grimmer Molina , Holz Jasmin A. , Zeyen Thomas , Friker Lea L. , Borger Valeri , Schmeel F. Carsten , Weller Johannes , Hölzel Michael , Schäfer Niklas , Garbe Stephan , Forstbauer Helmut , Giordano Frank A. , Herrlinger Ulrich , Vatter Hartmut , Schneider Matthias , Schmeel L. Christopher 
Published: July 2023

Abstract
Purpose
Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam radiation therapy (EBRT) following resection of brain metastases (BM). Advantages of IORT include an instant prevention of tumor regrowth, optimized dose-sparing of adjacent healthy brain tissue and immediate completion of BM treatment, allowing an earlier admission to subsequent systemic treatments. However, prospective outcome data are limited. We sought to assess long-term outcome of IORT in comparison to EBRT.

Methods
A total of 35 consecutive patients, prospectively recruited within a study registry, who received IORT following BM resection at a single neuro-oncological center were evaluated for radiation necrosis (RN) incidence rates, local control rates (LCR), distant brain progression (DBP) and overall survival (OS) as long-term outcome parameters. The 1 year-estimated OS and survival rates were compared in a balanced comparative matched-pair analysis to those of our institutional database, encompassing 388 consecutive patients who underwent adjuvant EBRT after BM resection.

Results
The median IORT dose was 30 Gy prescribed to the applicator surface. A 2.9% RN rate was observed. The estimated 1 year-LCR was 97.1% and the 1 year-DBP-free survival 73.5%. Median time to DBP was 6.4 (range 1.7–24) months in the subgroup of patients experiencing intracerebral progression. The median OS was 17.5 (0.5-not reached) months with a 1 year-survival rate of 61.3%, which did not not significantly differ from the comparative cohort (p = 0.55 and p = 0.82, respectively).

Conclusion
IORT is a safe and effective fast-track approach following BM resection, with comparable long-term outcomes as adjuvant EBRT.
Earthworm and soil microbial communities in flower strip mixtures
Authors: Bednar Zita , Vaupel Anna , Blümel Simon , Herwig Nadine , Hommel Bernd , Haberlah-Korr Verena , Beule Lukas 
Published: July 2023

Abstract
Aims
Incorporation of flower strips is an agricultural measure to increase aboveground biodiversity and ecosystem services. Although soil communities are key components of terrestrial biodiversity and drive important ecosystem services, their abundance, diversity, and composition in flower strips remain largely unexplored. Here, we shed light on earthworms and soil microorganisms in flower strips.

Methods
We sowed a grassy field margin vegetation as well as two annual and two perennial flower strip mixtures in fully randomized plots of 9 × 28 m in three different types of soil in Germany. Two years following sowing, we determined earthworm communities using chemical extraction and investigated the soil microbiome using real-time PCR (archaea, bacteria, fungi, and soil-N-cycling genes) and amplicon sequencing (bacteria and fungi).

Results
Different plant mixtures (i.e. field margin, annual and perennial flower strips) harbored distinct earthworm and soil microbial communities. Earthworm density and biomass declined or remained unaffected in annual flower strips but increased in perennial flower strips as compared to the field margins. Arbuscular mycorrhizal fungi showed greater diversity and relative abundance in non-tilled (i.e. field margin and perennial flower strips) than in tilled plant mixtures (i.e. annual flower strips).

Conclusions
We attribute changes in earthworm and microbial communities mainly to the effect of tillage and plant diversity. Overall, we suggest that perennial flower strips serve as refugia. Future studies should compare soil biota in perennial flower strips to those in adjacent fields and investigate whether the promotion of soil communities extends into adjacent fields (‘spillover’).
Adaptations of an Effective Evidence-Based Pediatric Weight Management Intervention
Authors: Bartee R. T. , Heelan K. A. , Golden C. A. , Hill J. L. , Porter G. C. , Abbey B. A. , George K. , Foster N. , Estabrooks P. A. 
Published: July 2023

AbstractCurrent childhood obesity treatment programs do not address medically underserved populations or settings where all members of an interdisciplinary team may not exist—either within one organization or within the community. In this paper, we describe the use of a community-academic partnership to iteratively adapt Epstein’s Traffic Light Diet (TLD), into Building Healthy Families (BHF), a community-placed evidence-based pediatric weight management intervention (PWMI) and evaluate its effectiveness in reducing BMIzscores. Nine cohorts of families completed BHF. Participants included children aged 6–12 years with obesity (M = 9.46, SD = 1.74). The Framework for Reporting Adaptations and Modifications-Expanded guided our classification of modifications across BHF cohorts. Using the FRAME reporting structure, the changes that were documented were (1) planned and occurred pre-implementation, (2) based on decisions from local stakeholders (e.g., school administrator, members of the implementation team), and (3) specific to changes in content and context—with a focus on implementation and potential for local scale-up. The nature of the adaptations included adding elements (whole of family approach), removing elements (calorie counting), and substituting elements (steps for minutes of physical activity). Across 9 cohorts, 84 families initiated the BHF program, 69 families successfully completed the 12-week program, and 45 families returned for 6-month follow-up assessments. Results indicated that the BMIzscore in children was reduced by 0.31 ± 0.17 at 6 months across all cohorts. Reduction in BMIzscore ranged from 0.41 in cohort 4 to 0.13 in cohort 5. Iterative adaptations to BHF were completed to improve the fit of BHF to the setting and participants and have contributed to a sustained community PWMI that adheres to the underlying principles and core elements of other evidence-based PWMIs. Monitoring adaptations and related changes to outcomes can play a role in long-term sustainability and effectiveness.
Loss of function of Hog1 improves glycerol assimilation in Saccharomyces cerevisiae
Authors: Sone Masato , Navanopparatsakul Kantawat , Takahashi Shunsuke , Furusawa Chikara , Hirasawa Takashi 
Published: July 2023

AbstractWe previously isolated a mutant of Saccharomyces cerevisiae strain 85_9 whose glycerol assimilation was improved through adaptive laboratory evolution. To investigate the mechanism for this improved glycerol assimilation, genome resequencing of the 85_9 strain was performed, and the mutations in the open reading frame of HOG1, SIR3, SSB2, and KGD2 genes were found. Among these, a frameshift mutation in the HOG1 open reading frame was responsible for the improved glycerol assimilation ability of the 85_9 strain. Moreover, the HOG1 gene disruption improved glycerol assimilation. As HOG1 encodes a mitogen-activated protein kinase (MAPK), which is responsible for the signal transduction cascade in response to osmotic stress, namely the high osmolarity glycerol (HOG) pathway, we investigated the effect of the disruption of PBS2 gene encoding MAPK kinase for Hog1 MAPK on glycerol assimilation, revealing that PBS2 disruption can increase glycerol assimilation. These results indicate that loss of function of Hog1 improves glycerol assimilation in S. cerevisiae. However, single disruption of the SSK2, SSK22 and STE11 genes encoding protein kinases responsible for Pbs2 phosphorylation in the HOG pathway did not increase glycerol assimilation, while their triple disruption partially improved glycerol assimilation in S. cerevisiae. In addition, the HOG1 frameshift mutation did not improve glycerol assimilation in the STL1-overexpressing RIM15 disruptant strain, which was previously constructed with high glycerol assimilation ability. Furthermore, the effectiveness of the HOG1 disruptant as a bioproduction host was validated, indicating that the HOG1 CYB2 double disruptant can produce L-lactic acid from glycerol.
Effect of green fuel and green lubricant with metallic nanoparticles on emissions of HC, CO, NOx, and smoke for a compression ignition engine
Authors: Barboza Augustine B. V. , Dinesha Pijakala , Rosen Marc A. 
Published: July 2023

AbstractThe United Nations Sustainable Development Goals (SDGs) are imperative from the point of view of protecting the environment by employing sustainable options. Considerable research has been carried out in the transportation sector to meet this objective. Here, the influence is assessed of epoxidised gingelly oil methyl ester biolubricant with alumina (Al2O3) nanoparticles on the performance and emissions of a single cylinder 0.66-L capacity direct injection compression ignition engine driven by gingelly B20 biodiesel. Engine tests are carried out with gingelly B20 biodiesel as a fuel, and gingelly methyl ester (B100), epoxidised gingelly methyl ester (B100E), and epoxidised gingelly methyl ester (B100E) mixed with 0.5%, 1.0%, and 1.5% w/w alumina (Al2O3) nanoparticles as the lubricant combinations. The results are compared with baseline B20 biodiesel fuel-mineral lubricant operation. The findings indicate that brake thermal efficiency increases by 8.64% for epoxidised gingelly methyl ester (B100E) with 1.0% w/w alumina (Al2O3) nanoparticle biolubricant in comparison to baseline operation. Considerable reductions in emissions are detected; specifically, reductions of 52.4%, 22.0%, 20.0%, and 34.9%, respectively, are observed for CO, NOx, and HC concentrations and smoke opacity for the abovementioned combination as compared to baseline operation. The present work suggests that further research is merited on green fuel-green lubricant combinations. The findings of this study address the United Nations Sustainable Development Goals (SDGs) 7 and 13.
Biofouling mechanism and cleaning procedures for Spirulina platensis as an organic fertilizer draw solution
Authors: Al Bazedi Ghada , Soliman Noha , Sewilam Hani 
Published: July 2023

AbstractThe forward osmosis (FO) desalination process has recently acknowledged a lot of attention as a promising solution for reducing the disadvantages of existing desalination systems. This work aimed to investigate the effect of a selected liquid organic fertilizer a novel draw solution produced from “microalgae Spirulina platensis” on the biofouling mechanism of FO membrane. Different draw solution (DS) concentrations ranging 240–480 g/L were examined, obtained water flux ranging from 6.5 to 3.4 Lm2h-1. A high flux decline was observed when using higher DS concentrations due to fouling layer accumulated throughout the membrane area which lowers the effective osmotic pressure difference. Different cleaning strategies were examined. The biofouled membrane was cleaned on-line with deionized water (DI) and externally using ultrasound (US) and HCl. Baseline experiments were done to investigate the efficiency of the cleaning strategies. After cleaning using the deionized water (DI) water, it was found that the water flux progressed from 3.4 to 7 Lm2h-1, while when using acid cleaning the flux recovered to 15 Lm-2h-1. The efficacy and amount of foulant removed by each cleaning stage were assessed using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX).
Impact of cardiac and respiratory motion on the 3D accuracy of image-guided interventions on monoplane systems
Authors: Bertsche Dagmar , Metze Patrick , Schneider Leonhard-Moritz , Vernikouskaya Ina , Rasche Volker 
Published: July 2023

Abstract
Purpose
Image-guided intervention (IGI) systems have the potential to increase the efficiency in interventional cardiology but face limitations from motion. Even though motion compensation approaches have been proposed, the resulting accuracy has rarely been quantified using in vivo data. The purpose of this study is to investigate the potential benefit of motion-compensation in IGS systems.

Methods
Patients scheduled for left atrial appendage closure (LAAc) underwent pre- and postprocedural non-contrast-enhanced cardiac magnetic resonance imaging (CMR). According to the clinical standard, the final position of the occluder device was routinely documented using x-ray fluoroscopy (XR). The accuracy of the IGI system was assessed retrospectively based on the distance of the 3D device marker location derived from the periprocedural XR data and the respective location as identified in the postprocedural CMR data.

Results
The assessment of the motion-compensation depending accuracy was possible based on the patient data. With motion synchronization, the measured accuracy of the IGI system resulted similar to the estimated accuracy, with almost negligible distances of the device marker positions identified in CMR and XR. Neglection of the cardiac and/or respiratory phase significantly increased the mean distances, with respiratory motion mainly reducing the accuracy with rather low impact on the precision, whereas cardiac motion decreased the accuracy and the precision of the image guidance.

Conclusions
In the presented work, the accuracy of the IGI system could be assessed based on in vivo data. Motion consideration clearly showed the potential to increase the accuracy in IGI systems. Where the general decrease in accuracy in non-motion-synchronized data did not come unexpected, a clear difference between cardiac and respiratory motion-induced errors was observed for LAAc data. Since sedation and intervention location close to the large vessels likely impacts the respiratory motion contribution, an intervention-specific accuracy analysis may be useful for other interventions.