bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Moderating Effect of Mental Health on the Relationship Between Cardiovascular Disease Awareness and Health Behaviors of Middle-Aged Korean Chinese Workers With Cardiovascular Risk Factors in Korea
Authors: Zhang Yu Zhu , Hwang Seon Young 
Published: February 2023

Introduction: Cardiovascular disease (CVD) remains a leading cause of death in China and Korea, yet little is known about in Korean Chinese workers. The purpose of the study was to investigate the effects of CVD awareness and mental health on health behaviors and evaluate the moderating effect of mental health on the relationship between CVD awareness and health behaviors among Korean Chinese workers. Method: We used a cross-sectional design and convenience sampling of participants from Seoul in December 2021. Data were analyzed using descriptive statistics, Pearson’s correlation coefficient, independent t tests, and hierarchical multiple regression analysis. Results: CVD awareness, mental health, and health behaviors were relatively low and mental health showed a moderating effect on the relationship between the two variables. Discussion: Understanding relationships between CVD awareness, socioculturally mediated health behaviors, and mental health issues is critical to CVD prevention among participants; moreover, mental health should be specifically assessed and targeted for improvement.
The evaluation of Hemoblast Bellows for arterial hemorrhage control in a swine model of vascular injury
Authors: Hafer Ashley , Verga Jared , Sulava Eric , Friedrich Emily , Sheldon Diana , Boboc Michael , Bohan Megan , Norris Emily , Gaspary Micah , Stuart Sean 
Published: February 2023

Background Uncontrolled hemorrhage remains the leading cause of preventable death on the battlefield. Hemostatic agents have increased in use and have been shown to improve survival. Combat Gauze (CG) is the most-used hemostatic gauze recommended by the Committee of Tactical Combat Casualty Care. Hemoblast Bellows (HB), a product FDA-approved for intraoperative hemorrhage, contains thrombin which differentiates it from CG and other kaolin-based hemostatic agents and has not been evaluated in the pre-hospital setting. This study aimed to compare HB to CG, in a standard swine arterial hemorrhage model. Methods Dilutional coagulopathy and hypothermia were induced in anesthetized Yorkshire-cross swine. The femoral artery was isolated and a 6 mm femoral arteriotomy was made. After a 30 s free bleed, randomly assigned hemostatic agent(s) from one of the three treatment groups: HB only, CG only, and HB + CG were applied and direct pressure was held for 3 min. At 30 min, the ipsilateral lower extremity was mobilized with a series of hip movements. Primary endpoints included blood loss, rebleeding, thromboelastogram (TEG) values, SPOT GRADE(TM) values, and mean arterial pressure (MAPs), which were monitored during the 150-min observation period. Results There were no significant differences between the treatment groups for blood loss, rebleeding, lactate, TEG values, SPOT GRADE, or MAPs for all time points examined. Conclusions We found no significant differences between the treatment groups for any of the included data points. These results suggest that arterial hemorrhage control with HB alone and HB + CG is not significantly different from hemorrhage control with CG only. These findings should not deter us from a continued investigation of hemostatic agents but should stimulate our search for superior hemorrhage control agents and novel delivery mechanisms. Continued innovation with such products may overcome the product limitations that we observed during testing and may prove to be a more relevant product for the point-of-injury.
Results of the in situ fenestration technique for preservation of the Left subclavian artery in the endovascular repair of acute aortic syndromes in a reference center
Authors: Pinheiro Ribeiro Alves André , da Costa Cettolin Queise , dos Santos Domingues Gustavo , dos Santos Humberto Álvaro Gonçalves , Sampaio Renata Caires , Aquino Mauricio de Amorim 
Published: February 2023

Introduction The in situ fenestration (ISF) technique consists of maintaining the patency of the aortic branch after the endoprosthesis is already in place as a viable, effective, and fast-performing alternative to revascularize the aortic arch arteries. Objective To report the experience with a series of cases of endovascular treatment of Acute Aortic Syndromes involving the aortic arch, using the ISF technique in a specialized center. Methods We analyzed data collected from patients treated with ISF during TEVAR for Acute Aortic Syndromes involving the aortic arch from June 2020 to January 2022, assessing perioperative outcomes, including immediate and late success rates, complications, morbidity and mortality, and short and medium term aortic branch patency. Results Of the 11 patients eligible for the ISF procedure, 9 were successful, with a technical success rate of 81%. No patient had a type 1A endoleak related to fenestration. There was complete thrombosis of the false lumen in the thoracic aorta in 77% cases. No death was related to the fenestration technique. Conclusion ISF as feasible and with a high rate of technical success and good results in the short and medium term. Prospective studies with long-term clinical follow-up are still needed to fully assess the durability of these unreinforced fenestrations.
Ten-year trends in sex differences in cardiovascular risk factors, in-hospital management, and outcomes of ischemic stroke in China: Analyses of a nationwide serial cross-sectional survey from 2005 to 2015
Authors: Gu Hong-Qiu , Wang Chun-Juan , Zhang Xin-Miao , Jiang Yong , Li Hao , Meng Xia , Yang Xin , Liu Li-Ping , Zhao Xing-Quan , Wang Yi-Long , Wang Yong-Jun , Li Zi-Xiao 
Published: February 2023

Background: Women with stroke differ from men in terms of risk factors, treatment, and outcomes. However, previous inconsistent results in China hampered the development of tailored sex-specific strategies for ischemic stroke management. We performed a nationwide serial cross-sectional survey to obtain national-level estimates to assess the 10-year trends in sex differences in cardiovascular risk factors, in-hospital management, and outcomes in China from 2005 to 2015. Methods: We used a two-stage random sampling design, economic-geographical region-stratified random sampling for hospitals first and then systematic sampling for patients, to obtain a nationally representative sample of ischemic strokes in China in 2005, 2010, and 2015. We extracted data on clinical characteristics, management measures (diagnostic tests, interventions, and secondary prevention treatments), in-hospital outcomes (all-cause in-hospital mortality, discharge against medical advice [DAMA], and a composite outcome of in-hospital death and DAMA), and comorbidities. We applied weights proportional to the inverse sampling fraction of hospitals within each stratum and the inverse sampling fraction of patients within each hospital. Results: A total of 26,900 ischemic stroke admissions were analyzed. Compared to men, women had a much lower prevalence of current smokers and a slightly higher prevalence of hypertension, diabetes, dyslipidemia, and atrial fibrillation at admission. Prevalence differences between sex in these cardiovascular risk factors were stable except for atrial fibrillation (decreased from 3.7% [95% CI: 1.8% to 5.7%] to 1.3% [95% CI: 0.5% to 2.0%]) and current smoker (increased from −18.0 [95% CI: –20.2% to –15.9%] to –25.6% [95% CI: –26.6% to –24.6%]). From 2005 to 2015, in-hospital management and outcomes were improved both for women and men, and sex differences in cerebrovascular assessment, cervical vessels assessment, and transthoracic echocardiography/transesophageal echocardiography were improved as well. However, women increased more slowly than men in the administration of clopidogrel (from 0.3% [95% CI: −0.9% to 1.4%) to −7.3% [95% CI: −8.7% to −6.0%]) and aspirin plus clopidogrel (0.3% [95% CI: −5.0% to 1.1%] to −5.0% [95% CI: −6.2% to −3.9%]). Conclusion: Compared to men, women patients with ischemic stroke had a steadily higher prevalence of cardiovascular risk factors, a slower increase rate in the administration of key secondary prevention drugs, and comparable in-hospital outcomes. More effort should be paid to the treatment and control of cardiovascular risk factors and also to the prescription of antiplatelets at discharge for women.
AngioJet rheolytic thrombectomy for the treatment of deep vein thrombosis in elderly patients: Increase the risk of acute kidney injury?
Authors: Gong Maofeng , Fu Guanqi , Liu Zhengli , Zhou Yangyi , Zhao Boxiang , Kong Jie , He Xu , Gu Jianping 
Published: February 2023

Objective The objective of this study was to investigate the risk of acute kidney injury in elderly patients compared with nonelderly patients undergoing AngioJet rheolytic thrombectomy for treatment of acute deep vein thrombosis. Methods A retrospective review of all patients who underwent AngioJet rheolytic thrombectomy for the treatment of acute deep vein thrombosis between November 1, 2014 and August 1, 2022 was conducted. Their baseline demographics, comorbidities, clinical characteristics, procedural details, and postoperative course were reviewed. Results A total of 105 eligible patients were reviewed; 45 patients were in the elderly group, and 60 were in the nonelderly group. Except for age ( p  < 0.001), no significant differences regarding demographics were detected ( p >0.05). Transient macroscopic hemoglobinuria occurred in all patients during the first 24 h post-AngioJet rheolytic thrombectomy. The overall morbidity of acute kidney injury in the two groups was 11.4%, and the nonelderly group had a similar rate of acute kidney injury (8.3%) to the elderly group (15.6%). None of the 12 patients progressed to dialysis within the postoperative period, and the mean acute kidney injury recovery time of the elderly group was 5.86 ± 1.57 days, which was longer than the 3.60 ± .89 days of the nonelderly group ( p = 0.017). Conclusion The use of AngioJet rheolytic thrombectomy for the treatment of patients with acute deep vein thrombosis is associated with a potential risk of acute kidney injury, which seems to have a comparable rate in elderly and nonelderly patients. acute kidney injury in the elderly group tends to need a longer recovery time, which requires postoperative vigilance for this population.
Sensitivity and specificity for detecting pseudotumors in patients with hip resurfacing arthroplasty, metal-on-metal or metal-on-polyethylene total hip arthroplasty—MRI versus ultrasonography performed by an orthopedic surgery resident
Authors: Mikkelsen Rasmus T , Schou Martin , Torfing Trine , Graumann Ole , Overgaard Søren , Varnum Claus 
Published: February 2023

Background Metal artifact reduction sequence magnetic resonance imaging (MRI) scan is a common method to detect adverse reaction to metal debris in total hip arthroplasty (THA). It might be quicker and cheaper if ultrasonography (US) could screen for the need for an MRI. However, both require trained personnel. Purpose We aimed to investigate the sensitivity and specificity of US for detecting pseudotumors (PT) when performed by an orthopedic surgery resident compared to MRI. We also investigated the sensitivity and specificity of US to detect PTs in obese and non-obese patients. Material and methods We examined 205 patients with hip resurfacing arthroplasty, metal-on-metal or metal-on-polyethylene THA with both MRI and US. US was performed by an orthopedic surgery resident who was trained according to a standardized training program in musculoskeletal US. Results from MRI were used as gold standard. Results US had a sensitivity of 0.92 (95% CI 0.81–0.98) and specificity of 0.94 (95% CI 0.89–0.97) for detecting PT. It had a positive predictive value of 0.84 (95% CI 0.73–0.91) and a negative predictive value of 0.97 (95% CI 0.93–0.99). US performed similarly in obese and non-obese patients. Conclusions US had a high sensitivity and specificity for detecting PT when performed by an orthopedic surgery resident. Trained orthopedic surgeons could screen for the need of an MRI scan when searching PTs.
Determining Prior Authorization Approval for Lumbar Stenosis Surgery With Machine Learning
Authors: De Barros Amaury , Abel Frederik , Kolisnyk Serhii , Geraci Gaspere C. , Hill Fred , Engrav Mary , Samavedi Sundara , Suldina Olga , Kim Jack , Rusakov Andrej , Lebl Darren R. , Mourad Raphael 
Published: February 2023

Study Design Medical vignettes. Objectives Lumbar spinal stenosis (LSS) is a degenerative condition with a high prevalence in the elderly population, that is associated with a significant economic burden and often requires spinal surgery. Prior authorization of surgical candidates is required before patients can be covered by a health plan and must be approved by medical directors (MDs), which is often subjective and clinician specific. In this study, we hypothesized that the prediction accuracy of machine learning (ML) methods regarding surgical candidates is comparable to that of a panel of MDs. Methods Based on patient demographic factors, previous therapeutic history, symptoms and physical examinations and imaging findings, we propose an ML which computes the probability of spinal surgical recommendations for LSS. The model implements a random forest model trained from medical vignette data reviewed by MDs. Sets of 400 and 100 medical vignettes reviewed by MDs were used for training and testing. Results The predictive accuracy of the machine learning model was with a root mean square error (RMSE) between model predictions and ground truth of .1123, while the average RMSE between individual MD’s recommendations and ground truth was .2661. For binary classification, the AUROC and Cohen’s kappa were .959 and .801, while the corresponding average metrics based on individual MD’s recommendations were .844 and .564, respectively. Conclusions Our results suggest that ML can be used to automate prior authorization approval of surgery for LSS with performance comparable to a panel of MDs.
Reliability and Validity of the German Version of the AO Spine Patient Reported Outcome Spine Trauma Questionnaire
Authors: Häckel Sonja , Oswald Katharina A. C. , Koller Leonie , Benneker Lorin M. , Benneker Layla A. , Sadiqi Said , Oner F. Cumhur , Deml Moritz C. 
Published: February 2023

Study Design A single-center validation study. Objective To translate and cross-culturally adapt the AO Spine PROST (Patient Reported Outcome Spine Trauma) into German, and to test its psychometric properties among German-speaking Swiss spine trauma patients. Methods Patients were recruited from a level-1 Swiss trauma center. Next to the AO Spine PROST, the EQ-5D-3L questionnaire was used for concurrent validity. Questionnaires were filled out at two-time points for test-retest reliability. Patient characteristics were analyzed using descriptive statistics. For content validity, floor, and ceiling effects, as well as any irrelevant and missing questions were analyzed. Construct validity of the AO Spine PROST questionnaire to the EQ-5D-3L was tested using Spearman correlation tests. Results The AOSpine PROST was translated and adapted into German using established guidelines. We included 179 patients. The floor effect for all items was well within the optimal range (below 15%), while the ceiling effect of seven items was within the optimal range. None of the items displayed a problematic floor or ceiling effect. The overall test-retest reliability of the total PROST score was excellent, with an ICC of .83 (95% CI .69-.91). The Spearman correlation coefficient between the total PROST summary score and EQ-5D-3 L was ρ = .63. Conclusions The German version of the AO Spine PROST questionnaire demonstrated very good validity and reliability results.
Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects
Authors: Cloos Anne-Sophie , Pollet Hélène , Stommen Amaury , Maja Mauriane , Lingurski Maxime , Brichard Bénédicte , Lambert Catherine , Henriet Patrick , Pierreux Christophe , Pyr dit Ruys Sébastien , Van Der Smissen Patrick , Vikkula Miikka , Gatto Laurent , Martin Manon , Brouillard Pascal , Vertommen Didier , Tyteca Donatienne 
Published: February 2023

AbstractSplenectomy improves the clinical parameters of patients with hereditary spherocytosis, but its potential benefit to red blood cell (RBC) functionality and the mechanism behind this benefit remain largely overlooked. Here, we compared 7 nonsplenectomized and 13 splenectomized patients with mutations in the β-spectrin or the ankyrin gene. We showed that hematological parameters, spherocyte abundance, osmotic fragility, intracellular calcium, and extracellular vesicle release were largely but not completely restored by splenectomy, whereas cryohemolysis was not. Affected RBCs exhibited decreases in β-spectrin and/or ankyrin contents and slight alterations in spectrin membrane distribution, depending on the mutation. These modifications were found in both splenectomized and nonsplenectomized patients and poorly correlated with RBC functionality alteration, suggesting additional impairments. Accordingly, we found an increased abundance of septins, small guanosine triphosphate–binding cytoskeletal proteins. Septins-2, -7, and -8 but not -11 were less abundant upon splenectomy and correlated with the disease severity. Septin-2 membrane association was confirmed by immunolabeling. Except for cryohemolysis, all parameters of RBC morphology and functionality correlated with septin abundance. The increased septin content might result from RBC maturation defects, as evidenced by (1) the decreased protein 4.2 and Rh-associated glycoprotein content in all patient RBCs, (2) increased endoplasmic reticulum remnants and endocytosis proteins in nonsplenectomized patients, and (3) increased lysosomal and mitochondrial remnants in splenectomized patients. Our study paves the way for a better understanding of the involvement of septins in RBC membrane biophysical properties. In addition, the lack of restoration of septin-independent cryohemolysis by splenectomy may call into question its recommendation in specific cases.
A novel comorbidity score for older adults with non-Hodgkin lymphoma: the 3-factor risk estimate scale
Authors: Gordon Max J. , Duan Zhigang , Zhao Hui , Nastoupil Loretta , Ferrajoli Alessandra , Danilov Alexey V. , Giordano Sharon H. 
Published: February 2023

Abstract
For patients with non-Hodgkin lymphoma (NHL), formal comorbidity assessment is recommended but is rarely conducted in routine practice. A simple, validated measure of comorbidities that standardizes their assessment could improve adherence to guidelines. We previously constructed the 3-factor risk estimate scale (TRES) among patients with chronic lymphocytic leukemia (CLL). Here, we investigated TRES in multiple NHL subtypes. In the surveillance, epidemiology, and end results–Medicare database, patients with NHL diagnosed from 2008 to 2017 were included. Upper gastrointestinal, endocrine, and vascular comorbidities were identified using ICD-9/ICD-10 codes to assign TRES scores. Patient characteristic distributions were compared using χ2 or t test. Association of mortality and TRES score was assessed using Kaplan-Meier and multivariable Cox regression model for competing risk. A total of 40 486 patients were included in the study. Median age was 77 years (interquartile range [IQR], 71-83 years). The most frequent NHL subtypes were CLL (28.2%), diffuse large B-cell (27.6%), and follicular lymphoma (12.6%). Median follow-up was 33 months (IQR, 13-60 months). TRES was low, intermediate, and high in 40.8%, 37.0%, and 22.2% of patients, corresponding to median overall survival (OS) of 8.2, 5.3, and 2.9 years (P &lt; .001), respectively. TRES was associated with OS in all NHL subtypes. In multivariable models, TRES was associated with inferior OS and NHL-specific survival. TRES is clinically translatable and associated with OS and lymphoma-specific survival in older adults with NHL.
Stress-Induced Deformation of Thin Copper Substrate in Double-Sided Lapping
Authors: Guo Jiang , He Zengxu , Pan Bo , Wang Bin , Bai Qian , Kong Jinxing , Kang Renke 
Published: February 2023

AbstractDouble-sided lapping is an precision machining method capable of obtaining high-precision surface. However, during the lapping process of thin pure copper substrate, the workpiece will be warped due to the influence of residual stress, including the machining stress and initial residual stress, which will deteriorate the flatness of the workpiece and ultimately affect the performance of components. In this study, finite element method (FEM) was adopted to study the effect of residual stress-related on the deformation of pure copper substrate during double-sided lapping. Considering the initial residual stress of the workpiece, the stress caused by the lapping and their distribution characteristics, a prediction model was proposed for simulating workpiece machining deformation in lapping process by measuring the material removal rate of the upper and lower surfaces of the workpiece under the corresponding parameters. The results showed that the primary cause of the warping deformation of the workpiece in the double-sided lapping is the redistribution of initial residual stress caused by uneven material removal on the both surfaces. The finite element simulation results were in good agreement with the experimental results.
Scalable synthesis of BiVO4 thin films via anodic plating and thermal calcination
Authors: Jiang Haoyang , Xiao Yongcheng , Zhong Miao 
Published: February 2023

AbstractFabrication of high-quality semiconductor thin films has long been a subject of keen interest in the photocatalytic field. Here, we report a facile, solution-based anodic plating and calcination for large-scale synthesis of BiVO4 thin films on indium tin oxide coated glass for use as photoanodes in solar water splitting. Using Na2SO3 as a sacrificial reagent, continuous solar H2 production with 94% Faradaic efficiency was obtained over 6 h of photoelectrochemical water splitting.
Diagnosis delay a family of Galloway-Mowat Syndrome caused by a classical splicing mutation of Lage3
Authors: Chen Yan , Yang Yan , Yang Yang , Rao Jia , Bai Haitao 
Published: February 2023

Abstract
Background
Galloway-Mowat syndrome (GAMOS) is a group of rare hereditary diseases by the combination of early onset steroid-resistant nephrotic syndrome (SRNS) and microcephaly with brain anomalies caused by WDR73, LAGE3, OSGEP, TP53RK, TPRKB, GON7, WDR4 or NUP133 mutations.

Case presentation
We present the clinical and genetic features of a two-year-old boy with early nephrotic syndrome, microcephaly, growth retardation hypotonia and hypothyroidism. Genetic testing showed the presence of a canonical-splice mutation in the LAGE3 gene (NM_006014: c.188 + 1C > T). A total of nine female members of the family carried the variant. Seven male members died prematurely, and three of them suffered from nephrotic syndrome, which is consistent with the x-linked gene map of the disease. The overall symptoms of the disease due to the LAGE3 mutation were mild compared to other pathogenic genes.

Conclusion
As far as we know, this is the largest family case of GAMOS2 caused by LAGE3 mutation found so far. We also compared other subtypes of GAMOS. Due to the heterogeneity of the renal phenotype, regular proteinuria screening is recommended for all patients diagnosed with GAMOS.