bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Atmospheric Gaseous Elemental Mercury Concentrations and Isotopic Compositions at Mt. Changbai During 2015–2021 and Mt. Ailao During 2017–2021 in China
Authors: Wu Xian , Fu Xuewu , Zhang Hui , Tang Kaihui , Wang Xun , Zhang Hui , Deng Qianwen , Zhang Leiming , Liu Kaiyun , Wu Qingru , Wang Shuxiao , Feng Xinbin 
Published: May 2023

AbstractChina is the largest contributor to the global total anthropogenic mercury (Hg) emissions. However, the trend in anthropogenic Hg emissions in recent years in China has not been effectively evaluated due to the lack of long‐term atmospheric Hg observations. This study documents the changes in atmospheric gaseous elemental mercury (GEM) concentrations and isotopic compositions at Mt. Changbai (MCB) in northeastern China during 2015–2021 and Mt. Ailao (MAL) in southwestern China during 2017–2021, and explores the potential factors controlling these changes. GEM concentrations showed continuous declines from 2015 to 2021 (−2.1 ± 0.6% yr−1) at MCB and from 2017 to 2021 (−4.0 ± 1.4% yr−1) at MAL. Accompanied with these GEM declines are positive shifts in δ202Hg (medians: from 0.42 to 0.46‰ at MCB and from 0.17 to 0.57‰ at MAL), and negative shifts in Δ199Hg (medians: from −0.17‰ to −0.21‰ at MCB and from −0.10‰ to −0.17‰ at MAL) and Δ200Hg values (medians: from −0.07‰ to −0.08‰ at MCB and from −0.03‰ to −0.05‰ at MAL) (at significant levels for Δ199Hg at MCB and δ202Hg and Δ199Hg at MAL). These changes were mainly caused by the decreases in regional anthropogenic emissions in the study areas. Based on a ternary mixing model with Δ199Hg and Δ200Hg as input, we estimate decline rates of 5.8 ± 2.8 and 4.8 ± 3.0% yr−1 for the regional anthropogenic GEM emissions in northeastern and southwestern China, respectively.
Investigating the Effect of Aerosol Uncertainty on Convective Precipitation Forecasting in South China's Coastal Area
Authors: Wang Yueya , Zhang Zijing , Chow Wing Sze , Wang Zhe , Yu Jian Zhen , Chi‐Hung Fung Jimmy , Shi Xiaoming 
Published: May 2023

AbstractPrevious studies on convective precipitation forecasting in South China have focused on the effects of multiscale dynamics and microphysics parameterizations. However, limited investigation has been conducted on how uncertainty in aerosol data might cause errors in quantitative precipitation forecast for South China's coastal convection. In this case study, we evaluated the impact of aerosol uncertainties on South China's severe coastal convection using convection‐permitting simulations. We estimated the variability range of aerosol concentrations with observations for the pre‐summer months. The simulation results suggest that the rainfall pattern and intensity change notably when aerosol concentrations are varied. Decreasing the concentration of water‐friendly (WF) aerosols intensifies precipitation through reduced cloud water number concentration and increased droplet size. Increasing the concentration of ice‐friendly (IF) aerosols results in up to 40% increase in vertical velocity and latent heat compared to minimal IF aerosol condition, by enhancing the heterogeneous process and dynamically intensifying convection. Consequently, the simulation with minimal WF and maximal IF aerosol concentrations shows prolonged intense precipitation over the entire life cycle of convection. However, when both WF and IF aerosols are set to minimal concentrations, the simulation produces the maximum peak rainfall rate, which is about 50% stronger than the simulation with the climatological mean concentration, due to an enhanced homogeneous process that results in a higher ice concentration and more efficient ice‐phase precipitation growth. Meanwhile, variation in aerosol concentration affects convection initiation (CI), with a lower concentration of WF aerosol inducing earlier CI onset. Decreasing hygroscopicity leads to higher precipitation.
A general methodology to measure the light-to-heat conversion efficiency of solid materials
Authors: Gu Kai , Zhong Haizheng 
Published: May 2023

AbstractLight-to-heat conversion has been intensively investigated due to the potential applications including photothermal therapy and solar energy harvesting. As a fundamental property of materials, accurate measurement of light-to-heat conversion efficiency (LHCE) is of vital importance in developing advanced materials for photothermal applications. Herein, we report a photothermal and electrothermal equivalence (PEE) method to measure the LHCE of solid materials by simulating the laser heating process with electric heating process. The temperature evolution of samples during electric heating process was firstly measured, enabling us to derive the heat dissipation coefficient by performing a linear fitting at thermal equilibrium. The LHCE of samples can be calculated under laser heating with the consideration of heat dissipation coefficient. We further discussed the effectiveness of assumptions by combining the theoretical analysis and experimental measurements, supporting the obtained small error within 5% and excellent reproducibility. This method is versatile to measure the LHCE of inorganic nanocrystals, carbon-based materials and organic materials, indicating the applicability of a variety of materials.
Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study
Authors: Zhong Bella , Tan Kenneth , Razak Abdul , Sackett Vathana , Machipisa Catherine , Zhou Lindsay , Samiee-Zafarghandy Samira , Sehgal Arvind , Hunt Rod W. , Pharande Pramod , Malhotra Atul 
Published: May 2023

Abstract
Background
Paracetamol is commonly used for analgesia and patent ductus arteriosus (PDA) treatment in preterm infants. We aimed to evaluate early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol during their neonatal admission.

Methods
This retrospective cohort study included surviving infants born at <29 weeks gestation, or with a birth weight of <1000 grams. Neurodevelopmental outcomes studied were early cerebral palsy (CP) or high risk of CP diagnosis, Hammersmith Infant Neurological Examination (HINE) score and Prechtl General Movement Assessment (GMA) at 3–4 months corrected age.

Results
Two hundred and forty-two infants were included, of which 123 were exposed to paracetamol. After adjusting for birth weight, sex and chronic lung disease, there were no significant associations between paracetamol exposure and early CP or high risk of CP diagnosis (aOR 1.46, 95% CI 0.61, 3.5), abnormal or absent GMA (aOR 0.82, 95% CI 0.37, 1.79) or HINE score (adjusted β −0.19, 95% CI −2.39, 2.01). Subgroup analysis stratifying paracetamol exposure into <180 mg/kg or ≥180 mg/kg cumulative dose found that neither had significant effects on outcomes.

Conclusions
In this cohort of extreme preterm infants, no significant association was found between exposure to paracetamol during the neonatal admission and adverse early neurodevelopment.

Impact

Paracetamol is commonly used in the neonatal period for analgesia and patent ductus arteriosus treatment in preterm infants, although prenatal paracetamol use has been associated with adverse neurodevelopmental outcomes.

Exposure to paracetamol during the neonatal admission was not associated with adverse early neurodevelopment at 3–4 months corrected age in this cohort of extreme preterm infants.

The findings from this observational study is consistent with the small body of literature supporting the lack of association between neonatal paracetamol exposure and adverse neurodevelopmental outcomes in preterm infants.
Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era
Authors: Correia Cristina , Maurer Matthew J. , McDonough Samantha J. , Schneider Paula A. , Ross Paige E. , Novak Anne J. , Feldman Andrew L. , Cerhan James R. , Slager Susan L. , Witzig Thomas E. , Eckloff Bruce W. , Li Hu , Nowakowski Grzegorz S. , Kaufmann Scott H. 
Published: May 2023

AbstractHow to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 mutations at activation-induced cytidine deaminase (AICDA) sites, we examined 11 AICDA mutational targets, including BCL2, BCL6, PAX5, PIM1, RHOH, SOCS, and MYC, in 199 newly diagnosed grade 1 and 2 FLs. BCL2 mutations with VAF ≥20% occurred in 52% of cases. Among 97 FL patients who did not initially receive rituximab-containing therapy, nonsynonymous BCL2 mutations at VAF ≥20% were associated with increased transformation risk (HR 3.01, 95% CI 1.04–8.78, p = 0.043) and a trend toward shorter event-free survival (EFS, median 20 months with mutations versus 54 months without, p = 0.052). Other sequenced genes were less frequently mutated and did not increase the prognostic value of the panel. Across the entire population, nonsynonymous BCL2 mutations at VAF ≥20% were associated with decreased EFS (HR 1.55, 95% CI 1.02–2.35, p = 0.043 after correction for FLIPI and treatment) and decreased overall survival after median 14-year follow-up (HR 1.82, 95% CI 1.05–3.17, p = 0.034). Thus, high VAF nonsynonymous BCL2 mutations remain prognostic even in the chemoimmunotherapy era.
Brillouin zone folding driven bound states in the continuum
Authors: Wang Wenhao , Srivastava Yogesh Kumar , Tan Thomas CaiWei , Wang Zhiming , Singh Ranjan 
Published: May 2023

AbstractNon-radiative bound states in the continuum (BICs) allow construction of resonant cavities with confined electromagnetic energy and high-quality (Q) factors. However, the sharp decay of the Q factor in the momentum space limits their usefulness for device applications. Here we demonstrate an approach to achieve sustainable ultrahigh Q factors by engineering Brillouin zone folding-induced BICs (BZF-BICs). All the guided modes are folded into the light cone through periodic perturbation that leads to the emergence of BZF-BICs possessing ultrahigh Q factors throughout the large, tunable momentum space. Unlike conventional BICs, BZF-BICs show perturbation-dependent dramatic enhancement of the Q factor in the entire momentum space and are robust against structural disorders. Our work provides a unique design path for BZF-BIC-based silicon metasurface cavities with extreme robustness against disorder while sustaining ultrahigh Q factors, offering potential applications in terahertz devices, nonlinear optics, quantum computing, and photonic integrated circuits.
Singularity response reveals entrainment properties in mammalian circadian clock
Authors: Masuda Kosaku , Kon Naohiro , Iizuka Kosuke , Fukada Yoshitaka , Sakurai Takeshi , Hirano Arisa 
Published: May 2023

AbstractEntrainment is characterized by phase response curves (PRCs), which provide a summary of responses to perturbations at each circadian phase. The synchronization of mammalian circadian clocks is accomplished through the receipt of a variety of inputs from both internal and external time cues. A comprehensive comparison of PRCs for various stimuli in each tissue is required. Herein, we demonstrate that PRCs in mammalian cells can be characterized using a recently developed estimation method based on singularity response (SR), which represents the response of desynchronized cellular clocks. We confirmed that PRCs can be reconstructed using single SR measurements and quantified response properties for various stimuli in several cell lines. SR analysis reveals that the phase and amplitude after resetting are distinguishable among stimuli. SRs in tissue slice cultures reveal tissue-specific entrainment properties. These results demonstrate that SRs can be employed to unveil entrainment mechanisms with diverse stimuli in multiscale mammalian clocks.
The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain
Authors: Leistner Conny , Wilkinson Martin , Burgess Ailidh , Lovatt Megan , Goodbody Stanley , Xu Yong , Deuchars Susan , Radford Sheena E. , Ranson Neil A. , Frank René A. W. 
Published: May 2023

AbstractAmyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). However, the molecular architecture of amyloid plaques in the context of fresh mammalian brain tissue is unknown. Here, using cryogenic correlated light and electron tomography we report the in situ molecular architecture of Aβ fibrils in the AppNL-G-F familial AD mouse model containing the Arctic mutation and an atomic model of ex vivo purified Arctic Aβ fibrils. We show that in-tissue Aβ fibrils are arranged in a lattice or parallel bundles, and are interdigitated by subcellular compartments, extracellular vesicles, extracellular droplets and extracellular multilamellar bodies. The Arctic Aβ fibril differs significantly from an earlier AppNL-F fibril structure, indicating a striking effect of the Arctic mutation. These structural data also revealed an ensemble of additional fibrillar species, including thin protofilament-like rods and branched fibrils. Together, these results provide a structural model for the dense network architecture that characterises β-amyloid plaque pathology.
Determination, measurement, and validation of maximal aerobic speed
Authors: Balasekaran Govindasamy , Loh Mun Keong , Boey Peggy , Ng Yew Cheo 
Published: May 2023

AbstractThis study determined Maximal Aerobic Speed (MAS) at a speed that utilizes maximal aerobic and minimal anaerobic contributions. This method of determining MAS was compared between endurance (ET) and sprint (ST) trained athletes. Nineteen and 21 healthy participants were selected for the determination and validation of MAS respectively. All athletes completed five exercise sessions in the laboratory. Participants validating MAS also ran an all-out 5000 m at the track. Oxygen uptake at MAS was at 96.09 ± 2.51% maximal oxygen consumption ($${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

V
˙

O
2max

). MAS had a significantly higher correlation with velocity at lactate threshold (vLT), critical speed, 5000 m, time-to-exhaustion velocity at delta 50 in addition to 5% velocity at $${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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O
2max

(TlimυΔ50 + 5%v$${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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˙

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2max

), and Vsub%95 (υΔ50 or υΔ50 + 5%v$${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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˙

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2max

) compared with v$${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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2max

, and predicted 5000 m speed (R2 = 0.90, p < 0.001) and vLT (R2 = 0.96, p < 0.001). ET athletes achieved significantly higher MAS (16.07 ± 1.58 km·h−1 vs. 12.77 ± 0.81 km·h−1, p ≤ 0.001) and maximal aerobic energy (EMAS) (52.87 ± 5.35 ml·kg−1·min−1 vs. 46.42 ± 3.38 ml·kg−1·min−1, p = 0.005) and significantly shorter duration at MAS (ET: 678.59 ± 165.44 s; ST: 840.28 ± 164.97 s, p = 0.039). ST athletes had significantly higher maximal speed (35.21 ± 1.90 km·h−1, p < 0.001) at a significantly longer distance (41.05 ± 3.14 m, p = 0.003) in the 50 m sprint run test. Significant differences were also observed in 50 m sprint performance (p < 0.001), and peak post-exercise blood lactate (p = 0.005). This study demonstrates that MAS is more accurate at a percentage of v$${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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˙

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2max

than at v$${{\dot{\rm{V}}}}\text{O}_{\text{2max}}$$

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. The accurate calculation of MAS can be used to predict running performances with lower errors (Running Energy Reserve Index Paper).
Happiness predicts compliance with preventive health behaviours during Covid-19 lockdowns
Authors: Krekel Christian , Swanke Sarah , De Neve Jan-Emmanuel , Fancourt Daisy 
Published: May 2023

AbstractTo combat the public health crisis of Covid-19, governments and public health officials have been asking individuals to substantially change their behaviours for prolonged periods of time. Are happier people more willing to comply with such measures? Using independent, large-scale surveys covering about 79,000 adult respondents across 29 countries, including longitudinal data from the UK, we find that life satisfaction predicts compliance with preventive health behaviours during Covid-19 lockdowns, especially the number of weekdays stood at home (β = 0.02, p < 0.01). The association is stronger for higher levels of life satisfaction (e.g. β = 0.19, p < 0.01, 7 on a 0-to-10 scale). Lower life satisfaction, on the contrary, predicts lower compliance (e.g. β = 0.02, p > 0.10, 2 on a 0-to-10 scale). We explore risk-avoidance and pro-social motivations for this relationship, and find suggestive evidence that people who are older or have certain medical preconditions seem to be behave in line with risk-avoidance, whereas motivations of people who are less at risk of Covid-19 seem more mixed. While it is difficult to estimate the relationship between life satisfaction and compliance behaviour due to potential confounders and unobserved heterogeneity, our findings suggest that life satisfaction is important, both for complying with preventive health measures and as a policy end in itself.
Selective area multilayer graphene synthesis using resistive nanoheater probe
Authors: Torres Ingrid , Aghaei Sadegh Mehdi , Pala Nezih , Gaitas Angelo 
Published: May 2023

AbstractGraphene has been a material of interest due to its versatile properties and wide variety of applications. However, production has been one of the most challenging aspects of graphene and multilayer graphene (MLG). Most synthesis techniques require elevated temperatures and additional steps to transfer graphene or MLG to a substrate, which compromises the integrity of the film. In this paper, metal-induced crystallization is explored to locally synthesize MLG directly on metal films, creating an MLG-metal composite and directly on insulating substrates with a moving resistive nanoheater probe at much lower temperature conditions (~ 250 °C). Raman spectroscopy shows that the resultant carbon structure has properties of MLG. The presented tip-based approach offers a much simpler MLG fabrication solution by eliminating the photolithographic and transfer steps of MLG.
Brain activity associated with quadriceps strength deficits after anterior cruciate ligament reconstruction
Authors: Criss Cody R. , Lepley Adam S. , Onate James A. , Clark Brian C. , Simon Janet E. , France Christopher R. , Grooms Dustin R. 
Published: May 2023

AbstractProlonged treatment resistant quadriceps weakness after anterior cruciate ligament reconstruction (ACL-R) contributes to re-injury risk, poor patient outcomes, and earlier development of osteoarthritis. The origin of post-injury weakness is in part neurological in nature, but it is unknown whether regional brain activity is related to clinical metrics of quadriceps weakness. Thus, the purpose of this investigation was to better understand the neural contributions to quadriceps weakness after injury by evaluating the relationship between brain activity for a quadriceps-dominated knee task (repeated cycles of unilateral knee flexion/extension from 45° to 0°), , and strength asymmetry in individuals returned to activity after ACL-R. Forty-four participants were recruited (22 with unilateral ACL reconstruction; 22 controls) and peak isokinetic knee extensor torque was assessed at 60°/s to calculate quadriceps limb symmetry index (Q-LSI, ratio of involved/uninvolved limb). Correlations were used to determine the relationship of mean % signal change within key sensorimotor brain regions and Q-LSI. Brain activity was also evaluated group wise based on clinical recommendations for strength (Q-LSI < 90%, n = 12; Q-LSI ≥ 90%, n = 10; controls, all n = 22 Q-LSI ≥ 90%). Lower Q-LSI was related to increased activity in the contralateral premotor cortex and lingual gyrus (p < .05). Those who did not meet clinical recommendations for strength demonstrated greater lingual gyrus activity compared to those who met clinical recommendations Q-LSI ≥ 90 and healthy controls (p < 0.05). Asymmetrically weak ACL-R patients displayed greater cortical activity than patients with no underlying asymmetry and healthy controls.
Machine learning-based country-level annual air pollutants exploration using Sentinel-5P and Google Earth Engine
Authors: Halder Bijay , Ahmadianfar Iman , Heddam Salim , Mussa Zainab Haider , Goliatt Leonardo , Tan Mou Leong , Sa’adi Zulfaqar , Al-Khafaji Zainab , Al-Ansari Nadhir , Jawad Ali H. , Yaseen Zaher Mundher 
Published: May 2023

AbstractClimatic condition is triggering human health emergencies and earth’s surface changes. Anthropogenic activities, such as built-up expansion, transportation development, industrial works, and some extreme phases, are the main reason for climate change and global warming. Air pollutants are increased gradually due to anthropogenic activities and triggering the earth’s health. Nitrogen Dioxide (NO2), Carbon Monoxide (CO), and Aerosol Optical Depth (AOD) are truthfully important for air quality measurement because those air pollutants are more harmful to the environment and human’s health. Earth observational Sentinel-5P is applied for monitoring the air pollutant and chemical conditions in the atmosphere from 2018 to 2021. The cloud computing-based Google Earth Engine (GEE) platform is applied for monitoring those air pollutants and chemical components in the atmosphere. The NO2 variation indicates high during the time because of the anthropogenic activities. Carbon Monoxide (CO) is also located high between two 1-month different maps. The 2020 and 2021 results indicate AQI change is high where 2018 and 2019 indicates low AQI throughout the year. The Kolkata have seven AQI monitoring station where high nitrogen dioxide recorded 102 (2018), 48 (2019), 26 (2020) and 98 (2021), where Delhi AQI stations recorded 99 (2018), 49 (2019), 37 (2020), and 107 (2021). Delhi, Kolkata, Mumbai, Pune, and Chennai recorded huge fluctuations of air pollutants during the study periods, where ~ 50–60% NO2 was recorded as high in the recent time. The AOD was noticed high in Uttar Pradesh in 2020. These results indicate that air pollutant investigation is much necessary for future planning and management otherwise; our planet earth is mostly affected by the anthropogenic and climatic conditions where maybe life does not exist.
Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth
Authors: Velentza Lilly , Wickström Malin , Kogner Per , Ohlsson Claes , Zaman Farasat , Sävendahl Lars 
Published: May 2023

AbstractTreatment-related skeletal complications are common in childhood cancer patients and survivors. Venetoclax is a BCL-2 inhibitor that has shown efficacy in hematological malignancies in adults and is being investigated in pediatric cancer clinical trials as a promising therapeutic modality. Venetoclax triggers cell death in cancer cells, but whether it exerts similar effects in normal bone cells, is unknown. Chondrogenic ATDC5 cells, E20 fetal rat metatarsal bones, and human growth plate biopsies were treated with different concentrations of venetoclax. Female NMRI nu/nu mice were treated with venetoclax or vehicle for 15 days. Mice were X-rayed at baseline and at the end of the experiment to assess longitudinal bone growth and body weight was monitored throughout the study. Histomorphometric and immunohistochemical analyses were performed to evaluate treatment effects on the growth plate cartilage. Venetoclax decreased the viability of chondrocytes and impaired the growth of ex vivo cultured metatarsals while reducing the height of the resting/proliferative zone and the hypertrophic cell size. When tested in vivo, venetoclax suppressed bone growth and reduced growth plate height. Our experimental data suggest that venetoclax directly targets growth plate chondrocytes suppressing bone growth and we, therefore, encourage careful monitoring of longitudinal bone growth if treating growing children with venetoclax.