bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misery of Long Haulers of COVID-19 - A Review
Authors: Pragi  , Kumar Varun , Garg Deepak 
Published: March 2023

Background:
Early in December 2019, Wuhan City, Hubei Province, China, had an epidemic
of the Coronavirus illness 2019 (COVID-19), which was brought on by a brand-new severe
acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). The epidemic was deemed a Public
Health Emergency of International Concern by the World Health Organization on January 30,
2020. Many governments have implemented a range of control measures as a result of perceived
illness risk.

Objectives:
The pandemic revealed that COVID-19 affects a variety of organs in addition to the
lungs, including the heart and brain, raising the risk of long-term health consequences. The illness
can affect someone's health even after recovery in a variety of ways. The long-term effects of
COVID-19 on locals are still being researched. The objective is to compile knowledge regarding
the virus and the present Post pandemic complications in Long Haulers.

Methods:
We reviewed the body of publicly available literature. To discover publications published
between December 2019 and October 2020, we conducted a systematic search utilizing the
keywords in online databases such as Pub Med, Scopus, Science Direct, Up to Date, and Web of
Science. The review includes peer-reviewed original publications published that matched the qualifying
requirements.

Results:
Although the majority of patients recovered quickly after receiving COVID-19, the possibility
of long-term issues induced by COVID-19 necessitates the search for and research of its late
consequences. This article aims to provide a comprehensive assessment of COVID-19 late complications
in order to determine how prevalent these symptoms are and who is most likely to be impacted.

Conclusion:
There are a number of difficulties with the COVID-19 pandemic that has yet to be resolved.
Review of the literature reported several long-lasting clinical problems that affect different
phases of health, including chronic fatigue, reduced physical capacity, muscle weakness, increased
depression, anxiety, post-traumatic stress disorder and sleep problems. A complete turndown in
quality of life has been observed even one year after major Coronavirus outbreaks.

:
The pandemic revealed that COVID-19 affects a variety of organs in addition to the lungs, including
the heart and brain, raising the risk of long-term health consequences even after years making
them to be “Long Haulers”.

:
The causal agent, pathogenesis, immunological responses, epidemiology, diagnosis, therapy, and
management of the disease, as well as control and preventive efforts, are all included in this review
of the literature.
A Telemedicine System Intervention for Patients With Type 1 Diabetes: Pilot Feasibility Crossover Intervention Study
Authors: Vlasakova Martina , Muzik Jan , Holubová Anna , Fiala Dominik , Arsand Eirik , Urbanová Jana , Janíčková Žďárská Denisa , Brabec Marek , Brož Jan 
Published: March 2023

Background
Today’s diabetes-oriented telemedicine systems can gather and analyze many parameters like blood glucose levels, carbohydrate intake, insulin doses, and physical activity levels (steps). Information collected can be presented to patients in a variety of graphical outputs. Despite the availability of several technical means, a large percentage of patients do not reach the goals established in their diabetes treatment.

Objective
The objective of the study was to evaluate the benefits of the Diani telemedicine system for the treatment of patients with type 1 diabetes mellitus.

Methods
Data were collected during a 24-week feasibility study. Patients responded to the World Health Organization Quality of Life – BREF (WHOQOL-BREF) questionnaire and a system evaluation questionnaire. The level of glycated hemoglobin (HbA1c) and the patient’s body weight were measured, and the patient’s use of the telemedicine system and their daily physical activity level were monitored. All data were sent from the patient’s device to the Diani server using a real-time diabetes diary app. Wilcoxon and Friedman tests and the linear mixed effects method were used for data analysis.

Results
This study involved 10 patients (men: n=5; women: n=5), with a mean age of 47.7 (SD 19.3) years, a mean duration of diabetes of 10.5 (SD 8.6) years, and a mean HbA1c value of 59.5 (SD 6.7) mmol/mol. The median number of days the patients used the system was 84. After the intervention, the mean HbA1c decreased by 4.35 mmol/mol (P=.01). The patients spent 18.6 (SD 6.8) minutes on average using the app daily. After the intervention, the number of patients who measured their blood glucose level at least 3 times a day increased by 30%. The graphical visualization of the monitored parameters, automatic transmission of measured data from the glucometer, compatibility, and interconnection of individual devices when entering data were positively evaluated by patients.

Conclusions
The Diani system was found to be beneficial for patients with type 1 diabetes mellitus in terms of managing their disease. Patients perceived it positively; it strengthened their knowledge of diabetes and their understanding of the influences of the measured values on the management of their disease. Its use had a positive effect on the HbA1c level.
Performance-Based Measurement of eHealth Literacy: Systematic Scoping Review
Authors: Crocker Bradley , Feng Olivia , Duncan Lindsay R 
Published: March 2023

Background
eHealth literacy describes the ability to locate, comprehend, evaluate, and apply web-based health information to a health problem. In studies of eHealth literacy, researchers have primarily assessed participants’ perceived eHealth literacy using a short self-report instrument, for which ample research has shown little to no association with actual performed eHealth-related skills. Performance-based measures of eHealth literacy may be more effective at assessing actual eHealth skills, yet such measures seem to be scarcer in the literature.

Objective
The primary purpose of this study was to identify tools that currently exist to measure eHealth literacy based on objective performance. A secondary purpose of this study was to characterize the prevalence of performance-based measurement of eHealth literacy in the literature compared with subjective measurement.

Methods
We conducted a systematic scoping review of the literature, aligning with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist, in 3 stages: conducting the search, screening articles, and extracting data into a summary table. The summary table includes terminology for eHealth literacy, description of participants, instrument design, health topics used, and a brief note on the evidence of validity for each performance-based measurement tool. A total of 1444 unique articles retrieved from 6 relevant databases (MEDLINE; PsycINFO; CINAHL; Library and Information Science Abstracts [LISA]; Library, Information Science & Technology Abstracts [LISTA]; and Education Resources Information Center [ERIC]) were considered for inclusion, of which 313 (21.68%) included a measure of eHealth literacy.

Results
Among the 313 articles that included a measure of eHealth literacy, we identified 33 (10.5%) that reported on 29 unique performance-based eHealth literacy measurement tools. The types of tools ranged from having participants answer health-related questions using the internet, having participants engage in simulated internet tasks, and having participants evaluate website quality to quizzing participants on their knowledge of health and the web-based health information–seeking process. In addition, among the 313 articles, we identified 280 (89.5%) that measured eHealth literacy using only a self-rating tool.

Conclusions
This study is the first research synthesis looking specifically at performance-based measures of eHealth literacy and may direct researchers toward existing performance-based measurement tools to be applied in future projects. We discuss some of the key benefits and drawbacks of different approaches to performance-based measurement of eHealth literacy. Researchers with an interest in gauging participants’ actual eHealth literacy (as opposed to perceived eHealth literacy) should make efforts to incorporate tools such as those identified in this systematic scoping review.
Perbandingan Kinerja Generalized Frequency Division Multiplexing Menggunakan Modulasi QAM dan Offset QAM
Authors: Ari Endang Jayati  , Budiani Destyningtias  
Published: March 2023

Generalized frequency division multiplexing (GFDM) merupakan sistem multicarrier masa datang yang bersifat nonortogonal. GFDM merupakan teknik transmisi data berbentuk blok yang setiap subcarrier-nya dibentuk dari pulsa berbentuk nonrectangular. Penerapan quadrature amplitude modulation (QAM) mapping untuk GFDM sangat baik karena meningkatkan efisiensi spektrum. QAM juga memiliki keterbatasan, yaitu meningkatnya kompleksitas ketika diimplementasikan. Selain itu, inter-carrier interference (ICI) juga masih ada dan sangat berpengaruh terhadap sistem. Untuk melakukan mitigasi terhadap kelemahan itu, digunakan teknik offset QAM (OQAM) mapping. Kelebihan GFDM/OQAM dibandingkan GFDM/QAM adalah komponen quadrature dan in-phase pada modulasi OQAM tidak mengalami pergeseran pada slot waktu yang sama, out of band (OOB) yang rendah, pesat data yang tinggi, dan bebas ICI. Makalah ini membandingkan dua skenario, yaitu sistem GFDM/OQAM dan sistem GFDM/QAM. Penelitian ini menganalisis kinerja bit error rate (BER) jika sinyal dilewatkan saluran additive white Gaussian noise (AWGN) dan saluran Rayleigh. Hasil simulasi menunjukkan bahwa GFDM/OQAM mempunyai kinerja lebih bagus. Hasil simulasi menunjukkan bahwa agar mendapatkan BER 10-2, terjadi penurunan nilai rasio energi per bit terhadap daya derau ( ) sebanyak 8 dB pada modulasi QAM ke OQAM ketika dilewatkan kanal AWGN. Sementara itu, ketika dilewatkan kanal Rayleigh, untuk mendapatkan nilai BER 10-2, terjadi penurunan nilai sebanyak 9 dB pada modulasi QAM ke OQAM. Selain itu, penelitian ini juga telah berhasil menyelidiki kinerja kedua sistem untuk parameter diagram konstelasi dan spektrum sinyal. Penelitian ini berhasil mendapatkan acuan nilai roll-off factor yang dapat digunakan pada penerapan sistem GFDM/OQAM dengan hasil kinerja terbaik yaitu 0,3. Faktor nilai roll-off factor sangat memengaruhi kinerja pada sistem GFDM.
Review of Russian Abstracts Accepted for United European Gastroenterology Week (2022)
Authors: Sheptulin A. A. 
Published: March 2023

Aim: to present an analysis of the Russian abstracts published in the materials of the 30th. United European Gastroenterology Week (UEGW).Key points. In the materials of 30 UEGW, 17 abstracts of Russian authors from Moscow, St. Petersburg, Novosibirsk, Kazan and other cities were published. The abstracts were devoted to topical issues of pathogenesis, diagnosis and treatment of intestinal liver and pancreatic diseases.Conclusion. Analysis of the published abstracts testifies to the high scientific level and large practical significance of the conducted research.
Screening and Early Diagnosis of Hepatocellular Cancer and Optimization of Diagnostic Imaging Techniques: A Review and Conclusion of the Expert Panel
Authors: Breder V. V. , Alikhanov R. B. , Bagnenko S. S. , Bessonova E. N. , Isakov V. A. , Kudashkin N. E. , Medvedeva B. M. , Mishchenko A. V. , Novruzbekov M. S. , Rudakov V. S. 
Published: March 2023

Аim: to describe modern approaches for screening and early diagnosis of hepatocellular carcinoma (HCC).Key points. Screening for HCC in high-risk groups (cirrhosis of any etiology, patients with chronic viral hepatitis B and patients with F3 liver fibrosis) should be organized as regular (every 6 months) liver ultrasound in combination with determination of the serum alpha-fetoprotein (AFP) level. At an AFP level of ≥ 20 ng/ml, even in the absence of changes according to ultrasound data, it is advisable to perform MRI with a hepatospecific contrast agent (gadoxetic acid) which makes it possible to detect very small focal liver lesions. If focal liver lesions of 1–2 cm are detected on ultrasound, additional imaging of the liver using MRI with a hepatospecific contrast agent gadoxetic acid helps to identify HCC at an earlier stage or high degree dysplastic nodes. When planning surgical treatment and liver transplantation, it is preferable to use MRI with a hepatospecific contrast agent, since the presence of the hepatobiliary phase may allow the detection of additional smaller focal liver lesions and assess the nature of the focal liver lesion. When a patient is included in the waiting list for liver transplantation, the optimal frequency of liver MRI is 1 time in 3 months.Conclusion. MRI with hepatospecific contrast agent gadoxetic acid is effective in screening, early diagnosis and treatment planning for HCC.
Pathology of the Gastrointestinal Tract in Patients with Primary Hyperparathyroidism
Authors: Baranova I. A. , Baranov A. V. 
Published: March 2023

Aim. To present data of Russian and foreign studies on the prevalence, pathogenesis and clinical picture of gastrointestinal tract (GIT) pathology in patients with primary hyperparathyroidism (PHPT).Key point. At the beginning of the 20th century PHPT was considered a severe endocrine disease with specific bone and kidney complications, however in 1957 W.T. St Goar proposed a mnemonic triad to recognize this pathology as “diseases of stones, bones and abdominal groans”. A high frequency of gastrointestinal complaints, peptic ulcer, pancreatitis, cholelithiasis in patients with PHPT has been reported. Hyperparathyroidism has been shown to cause smooth muscle atony with specific upper and lower GI symptoms such as nausea, heartburn and constipation. The prevalence of peptic ulcer in patients with PHPT, according to studies of the 50s–60s of the last century, ranged from 10 to 25 %. However, studies linking PHPT to peptic ulcer development were performed before the advent of proton 1). On the other hand, the development of pancreatitis in PHPT is one of the most studied pathologies. In developing countries its frequency can reach 10–20 % due to the absence of routine screening for blood calcium. Some authors report the impact of elevated parathyroid hormone levels on the formation of gallbladder stones by inhibiting of gallbladder emptying, hepatic bile secretion and mobility of the sphincter Oddi, and changing of the bile composition. A number of studies have found an increased risk of developing malignant neoplasms of the intestine, especially the colon, in patients with PHPT.Conclusion. The digestive manifestations of parathyroid dysfunction in patients can often be overlooked, and serum calcium levels should be included in the routine examination in the presence of abdominal symptoms.
Laser Based <sup>13</sup>C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa
Authors: Stepanov E. V. , Ivashkin V. T. 
Published: March 2023

Aim: to compare the results of 13C-UBT with the data of morphological analysis of the gastric and duodenal mucosa obtained during gastroduodenoscopy in gastritis and peptic ulcer. To analyze the dependence of the results of diode laser spectroscopy (DLS) based 13C-UBT on age, nosology, activity and severity of the inflammatory process, the degree of atrophy and metaplasia.Materials and methods. The 13C-UBT DLS was performed in 525 patients before the start of eradication therapy and in 196 patients 10–12 weeks after its completion. The breath test was carried out according to a standard protocol using the BSIA patent kit (Great Britain). During endoscopy, 134 patients underwent a biopsy from the upper third of the body of the stomach, the antrum (within 5 cm from the pylorus along the greater curvature) and the duodenal bulb with histological examination with hematoxylin-eosin staining, PAS-reaction and Giemsa. Histological assessment of the state of the gastric mucosa was carried out according to a modified Sydney system with an assessment of morphological changes according to a 4-point visual analog scale (0 to 3+).Results. A total of 525 patients (301 men and 224 women) aged 15–80 years (median 39.8 ± 15.1 years) were examined. 239 (45.5 %) patients were diagnosed with chronic gastritis, chronic duodenitis (including erosive forms). In 286 (54.5 %) patients, peptic ulcer was diagnosed with localization in the stomach — in 42 (8 %), in the duodenum – in 238 (45.3 %), combined lesions — in 9 (1.7 %) cases. Based on the results of 13C-UDT DLS, H. рylori infection was detected in 447 patients. H. рylori was not found in erosive gastritis in 15 %, erosive duodenitis in 21 % and chronic non-erosive gastritis in 23 %. In peptic ulcer of the stomach and duodenum, H. pylori was detected in 93 % and 97 %.A direct linear relationship between the results of the breath test and the quantitative content of H. рylori on the surface of the gastric mucosa was obtained. The parameters of laser 13C-UBT clearly correlate with the degree of severity of mononuclear infiltration of the mucosa (the strength of the connection is 0.78). When comparing the average values of laser 13C-UBT with the total assessment of the degree of mucosal neutrophilic infiltration, no significant relationship was found. With a slight severity of mucosal atrophy, the result of laser based 13C-UBT practically does not change; there is a tendency of a decrease in the breath test with an increase in atrophic changes.Conclusion. Indicators of 13C-UBT correlate with the quantitative content of H. pylori bacteria in the gastric mucosa, the severity of mononuclear infiltration of the gastroduodenal mucous, the severity of atrophic changes.
Course of COVID-19 in Patients with Inflammatory Bowel Disease: Regional Experience
Authors: Kupkenova L. M. , Belousova E. N. , Bodryagina E. S. , Mukhametova D. D. , Odintsova A. Kh. , Iskhakova D. G. , Abdulganieva D. I. 
Published: March 2023

Aim:to study the course of COVID-19 in patients with inflammatory bowel diseases (IBD) using the example of the region of the Republic of Tatarstan.Material and methods.The study included 101 patients diagnosed with IBD and COVID-19, who were observed in two infectious diseases hospitals in Kazan (Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan and City Clinical Hospital No. 7) and on an outpatient basis from April 2020 to March 2022. All patients underwent physical examination, laboratory and instrumental diagnostic methods, including a PCR test for SARSCoV-2. Chest computed tomography was performed in patients with clinical signs of moderate to severe COVID-19.Results.Ulcerative colitis (UC) was diagnosed in 60 (59.4 %) patients, Crohn's disease (CD) — in 41 (40.6 %) patients. The mean age of the patients was 41.0 ± 14.7 years, of which 59 (58.4 %) were men and 42 (41.6 %) were women. A comparative analysis of patients with and without IBD and CT-verified lung disease was carried out. It was found that the development of viral pneumonia was influenced by age over 55 years (39.2 ± 9.7 vs. 46.3 ± 10.6,p< 0.05), increased Body Mass Index (BMI) (23.1 ± 5.35 vs. 30.25 ± 6.17,p< 0.05), hypertension (6 (8.3 %) vs. 8 (27.6 %),p< 0.05), diabetes mellitus (2 (2.7 %) vs. 5 (17.2 %),p< 0.05), the use of corticosteroids in the treatment of IBD (8 (11.1 %) vs. 10 (34.5 %),p< 0.05). In a comparative analysis of patients with IBD and COVID-19 from the SECURE-IBD database and own data, it was found that the average age of patients was comparable (42.7 vs 41.0). At the same time, in our group of male patients, there were slightly more people with DM, increased BMI, and an active course of IBD. The proportion of hospitalized patients was higher. In our cohort, there were fewer patients receiving biological therapy, but more patients on 5-aminosalicylic acid (5-ASA) and systemic corticosteroids. At the same time, lethal outcomes were comparable.Conclusion.In patients with IBD, the development of viral pneumonia was influenced by known risk factors for COVID-19: age over 55 years (p< 0.05, odds ratio (OR) 3.153), increased BMI (p< 0.05, OR 1.667), hypertension (p< 0.05, OR 2.724), diabetes (p< 0.05, OR 1.489), as well as the use of systemic corticosteroids (p< 0.05, OR 1.5).
Ischemic Changes in the Mucous Membrane of the Transverse Colon as a Complication of Acute Pancreatitis
Authors: Semenov D. A. , Shapovalyants S. G. , Seleznev D. E. , Yudin O. I. , Korolev S. V. , Gracheva N. A. , Mikhaleva L. M. , Paramonenko K. S. 
Published: March 2023

Aim: to present a clinical case of a patient with a complicated course of acute pancreatitis.Key points. A 31-year-old patient was admitted to the surgical department with a clinical picture of acute alcoholic pancreatitis. Signs of anemia were regarded as a consequence of gastrointestinal bleeding. Computed tomography with contrast enhancement, along with an increase in the size of the pancreas, the presence of foci of pancreatic necrosis with multiple fluid accumulations in the parapancreatic space, revealed smoothed gaustration and thickening of the walls of the predominantly transverse colon. During colonoscopy, ischemic changes of the colon mucosa were detected in a timely manner. Negative results of analysis for toxins A and B of Clostridioides difficile and pathogenic intestinal flora were obtained. By the means of intensive care, it was possible to achieve complete stabilization of the patient's condition, normalization of laboratory blood parameters and relief of ischemic processes in the colon wall.Conclusion. Ischemic changes of the colon can serve as a complication of acute pancreatitis. A thorough analysis of the results of computed tomography at the first signs of colon lesion and colonoscopy contributed to the rapid detection of complications and prevention of irreversible colon ischemia.
Analisis Sosial Kelompok Masyarakat di Kawasan Wisata Pantai Pulau Merah dalam Implementasi SOP Pengelolaan Sampah Plastik di Destinasi Wisata Bahari
Authors: Muyasaroh Siti , Muzaqi Ahmad , Defriatno Mawan Eko , Krisdhianto Andhi 
Published: March 2023

Perkembangan pariwisata selain berdampak terhadap pertumbuhan ekonomi masyarakat, tetapi juga membawa dampak negatif terhadap lingkungan. Melihat urgensi permasalahan sampah di destinasi wisata bahari, diperlukan pengelolaan sampah yang bertanggung jawab dan berkelanjutan. Penelitian ini bertujuan untuk menganalisa kondisi eksisting persampahan dan memberikan rekomendasi pengelolaan sampah. Penelitian dilaksanakan selama satu bulan, yaitu 26 Agustus-September 2021 menggunakan metode kualitatif deskriptif. Rekomendasi struktur kelembagaan UPS Pulau Merah sebagai lembaga legal yang mengelola sampah di kawasan destinasi wisata perlu segera diwujudkan melalui surat Keputusan (SK) Kepala Desa Sumberagung. Dalam operasionalnya, diperlukan panduan teknis berupa SOP. Peningkatan partisipasi masyarakat dapat dilakukan dengan sosialisasi dan edukasi secara bertahap. Selain itu, perlu dilakukan upaya-upaya pengembangan sumber pendanaan agar pengelolaan sampah di kawasan wisata bahari dan sekitarnya dapat berjalan optimal dan berkelanjutan.