bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualizing Uncertainty in Hurricane Forecasts with Animated Risk Trajectories
Authors: Witt Jessica K. , Labe Zachary M. , Warden Amelia C. , Clegg Benjamin A. 
Published: April 2023

Abstract
Hurricane forecasts are often communicated through visualizations depicting the possible future track of the storm. The cone of uncertainty (COU) is a commonly used visualization, but the graphic is prone to misinterpretation such as thinking only locations contained within the cone’s boundary are at risk. In this study, we investigated the utility of conveying hurricane forecast tracks using a set of animated icons, each representing an instance of a possible storm path. We refer to this new visualization as animated risk trajectories (ARTs). We measured nonexperts’ perception of risk when viewing simplified, hypothetical hurricane forecasts presented as ARTs or COUs. To measure perception of risk for each visualization type, we designed experiments to have participants make decisions to evacuate individual towns at varying distances from the most likely forecast path of a storm. The ARTs led to greater risk perception in areas that fell beyond the cone’s boundaries. Nonexperts’ interpretation of risk was impacted by the visual properties of the ARTs, such as the distribution of the icons, including their density, and whether the distribution was unimodal or bimodal. This supports the suggestion that ARTs can have value in communicating spatial–temporal uncertainty.

Significance Statement
Because of the inherent uncertainties in weather forecasts and emergency management planning, communicating hurricane risk to the public is a unique challenge for decision-makers. Our study investigated the effect of conveying uncertainty in hurricane forecast tracks using a distribution of animated icons [animated risk trajectories (ARTs)], which correspond to potential hurricane tracks that evolve over time. This visualization was compared with a simplified cone-of-uncertainty graphic, such as those used by the National Hurricane Center. We found that ARTs offered flexibility in conveying information about hurricane risk, such as the magnitude of the risk via the number of icons and the location of the risk via the distribution of icons.
Health-related quality of life of women with breast cancer being treated with hormone therapy: A scoping review
Authors: Corpes Erilaine de F , Yanez Romel J V , Silva Denise M da , Leite Kauane M , Martins Milena C T , Vieira Milena M , Santos Cristina P R S dos , Fernandes Ana F C , Castro Régia C M B 
Published: April 2023

Objective To map the evidence available in the literature on the health-related quality of life of women with breast cancer using hormone therapy. Data sources This review followed the Joanna Briggs Institute methodological recommendations and Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews reporting guidelines. Searches were performed in nine databases using descriptors, synonyms and keywords; grey literature was also included. The review protocol was registered with the Open Science Framework under doi: http://doi.org/10.17605/OSF.IO/347FM . Inclusion criteria were established according to the Population, Concept, and Context strategy. The selection of studies was performed by two independent reviewers with the aid of RAYYAN software and disagreements were resolved by a third reviewer. The main information from the included articles was grouped into textual categories and presented by means of a narrative synthesis. Data Summary A total of 5419 records were identified, of which 42 studies fully met the eligibility criteria. Most were multicenter studies (42.9%) and randomized controlled trials (62%). Most studies addressed anastrozole (39.5%), letrozole (34.2%), and tamoxifen (26.3%), which were studied alone or in combination. The most widely used health-related quality-of-life assessment tool was the EORTC-QLQ-C30. The concomitant use of hormone therapy and cyclin-dependent kinase inhibitors 4 and 6 showed improvement in health-related quality of life. Conclusion In recent years there has been an increase in studies focused on health-related quality of life, and the evidence pointed to relevant information on health-related quality of life and the use of endocrine therapy, tamoxifen in combination with aromatase inhibitors, as well as aromatase inhibitor alone and the use of cyclin-dependent kinase 4 and 6.
Patterns and predictors of antidepressant prescribing among adults with cancer and depression in ambulatory care settings in the United States
Authors: Vadiei Nina , Le Alexander , Lopez Alfredo , Ponciano Anael , Smiley Desiree 
Published: April 2023

Objective Despite depression being a common comorbidity among adults with cancer, limited literature is available regarding pharmacologic depression treatment patterns and predictors in this population. This study aims to examine patterns and predictors of antidepressant prescribing among adults with cancer and depression in ambulatory care settings in the United States (US). Methods This retrospective, cross-sectional study utilized data collected from the 2014 to 2015 National Ambulatory Medical Care Survey (NAMCS). The study sample consisted of adults (age ≥ 18 years) with cancer and depression (unweighted N = 539; weighted N = 11,361,000). A multivariable logistic regression analysis was used to adjust for individual-level factors to identify predictors of antidepressant prescribing. Results Most patients were adults aged ≥ 65 years, female, and non-Hispanic whites. Thirty-seven percent of the study sample received antidepressant treatment. Multivariable logistic regression analysis revealed that race/ethnicity, physician specialty, and number of medications were significantly associated with receiving antidepressant(s). For example, non-Hispanic whites were two-and-half times more likely to receive an antidepressant [OR 2.43, 95% confidence interval 1.13–5.23] compared to other race/ethnic groups. Every unit increase in the number of prescribed medications increased the likelihood of receiving an antidepressant by 6% (OR 1.06, 95% CI: 1.01–1.11). Conclusion Among adults with a comorbid cancer and depression diagnosis and a recorded U.S. ambulatory care visit in 2014–2015, 37% received antidepressant treatment. This suggests most patients with cancer and depression do not receive pharmacologic treatment for depression. Future studies are needed to investigate the impact of antidepressant treatment on health outcomes in this patient population.
Influence of Non-uniform Parameter of Bolt Joint on Complexity of Frequency Characteristics of Cylindrical Shell
Authors: Tang Qiansheng , She Houxin , Li Chaofeng , Wen Bangchun 
Published: April 2023

AbstractBolt connection is one of the main fixing methods of cylindrical shell structures. A typical bolted connection model is considered as a tuned system. However, in the actual working conditions, due to the manufacturing error, installation error and uneven materials of bolts, there are always random errors between different bolts. To investigate the influence of non-uniform parameters of bolt joint, including the stiffness and the distribution position, on frequency complexity characteristics of cylindrical shell through a statistical method is the main aim of this paper. The bolted joints considered here were simplified as a series of springs with random features. The vibration equation of the bolted joined cylindrical shell was derived based on Sanders’ thin shell theory. The Monte Carlo simulation and statistical theory were applied to the statistical analysis of mode characteristics of the system. First, the frequency and mode shape of the tuned system were investigated and compared with FEM. Then, the effect of the random distribution and the random constraint stiffness of the bolts on the frequency and mode shape were studied. And the statistical analysis on the natural frequencies was evaluated for different mistuned levels. And some special cases were presented to help understand the effect of random mistuning. This research introduces random theory into the modeling of bolted joints and proposes a reference result to interpret the complexity of the modal characteristics of cylindrical shells with non-uniform parameters of bolt joints.
Pre-research on Enhanced Heat Transfer Method for Special Vehicles at High Altitude Based on Machine Learning
Authors: Li Chunming , Sun Xiaoxia , Gao Hongyang , Zhang Yu 
Published: April 2023

AbstractThe performance of an integrated thermal management system significantly influences the stability of special-purpose vehicles; thus, enhancing the heat transfer of the radiator is of great significance. Common research methods for radiators include fluid mechanics numerical simulations and experimental measurements, both of which are time-consuming and expensive. Applying the surrogate model to the analysis of the flow and heat transfer in louvered fins can effectively reduce the computational cost and obtain more data. A simplified louvered-fin heat transfer unit was established, and computational fluid dynamics (CFD) simulations were conducted to obtain the flow and heat transfer characteristics of the geometric structure. A three-factor and six-level orthogonal design was established with three structural parameters: angle θ, length a, and pitch Lp of the louvered fins. The results of the orthogonal design were subjected to a range analysis, and the effects of the three parameters θ, a, and Lp on the j, f, and JF factors were obtained. Accordingly, a proxy model of the heat transfer performance for louvered fins was established based on the artificial neural network algorithm, and the model was trained with the data obtained by the orthogonal design. Finally, the fin structure with the largest JF factor was realized. Compared with the original model, the optimized model improved the heat transfer factor j by 2.87%, decreased the friction factor f by 30.4%, and increased the comprehensive factor JF by 15.7%.
CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study
Authors: Cai Nan , Li Cunren , Gu Xianfang , Zeng Wenfeng , Zhong Jiawei , Liu Jingfeng , Zeng Guopeng , Zhu Junxing , Hong Haifeng 
Published: April 2023

AbstractBackgroundGenetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population.MethodsThe study included 1,872 hypertensive patients and 1,110 controls. The genotypes ofCYP2C19rs4244285 and rs4986893 of all individuals were detected and analyzed.ResultsThe genotype and allele distributions ofCYP2C19rs4244285 were significantly different between hypertension group and control group. TheCYP2C19*1/*1 genotype was the most predominant among the subjects (40.8%), followed by theCYP2C19*1/*2 genotype (40.5%). The percentage ofCYP2C19*1, *2, and *3 allele was 64.2%, 30.8%, and 5.0%, respectively. The proportion of intermediate metabolizers (IM) (49.3% vs. 42.9%), poor metabolizers (PM) (14.3% vs. 8.9%) (P < 0.001), andCYP2C19*2 allele (33.8% vs. 25.7%,P < 0.001) in hypertension group was significantly higher than that in control group. Multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated thatCYP2C19*1/*2, *1/*3, and *2/*2 genotypes may increase susceptibility to hypertension. And theCYP2C19IM genotype (IM vs. EM: OR 1.514, 95% CI: 1.291–1.775,P < 0.001), PM genotype (PM vs. EM: OR 2.120, 95% CI: 1.638–2.743,P < 0.001), IM + PM genotypes (IM + PM vs. EM: OR 1.617, 95% CI: 1.390–1.882,P < 0.001) may increase risk of hypertension.ConclusionsCYP2C19loss-of-function (IM, PM genotypes) is independent risk factor for hypertension susceptibility. Specifically, the risk genotypes includeCYP2C19*1/*2, *1/*3, and *2/*2.
Factors affecting the immunogenicity of influenza vaccines in human
Authors: Xu Qiuyi , Wei Hejiang , Wen Simin , Chen Jiamin , Lei Yuxuan , Cheng Yanhui , Huang Weijuan , Wang Dayan , Shu Yuelong 
Published: April 2023

Abstract
Background
The influenza viruses pose a threat to human health and medical services, and vaccination is an important way to prevent infection. However, the effectiveness of influenza vaccines is affected by various aspects. This study aimed to explore factors related to the immune response to influenza vaccines.

Methods
The study was conducted from September 2019 to September 2021, and a total of 593 volunteers were recruited from the Center for Disease Control and Prevention in 3 provinces in China. The hemagglutination inhibition assay was used to measure antibody levels. The Chi-square test, multivariable logistic regression analysis, and sum-rank test were used to analyze the factors associated with influenza vaccine immune response.

Results
The Chi-square test showed that seroconversion rates and response rate were associated with age group, vaccination history, chronic conditions, the frequency of colds, and region (P < 0.05). The multivariable logistic regression analysis showed that age was an important factor that affected participants’ seroconversion rates for A/H1N1, A/H3N2, B/Victoria, and response status (18–64 vs. ≤5: OR = 2.77, P < 0.001; ≥65 vs. ≤5: OR = 0.38, P = 0.01; 18–64 vs. ≤5: OR = 2.64, P = 0.03). Vaccination history was also an affecting factor for A/H1N1, B/Victoria, and response status (yes vs. no: OR = 0.4 / 0.44 / 0.25, P < 0.001). The frequency of colds and chronic conditions were also affecting factors for participants’ seroconversion rates and response levels to different degrees. The sum-rank test showed that the fold changes for A/H1N1, B/Victoria, and B/Yamagata were associated with age group and vaccination history (P < 0.01). The fold changes for A/H3N2 were associated with the frequency of colds (P < 0.05), and those for B/Victoria were associated with gender and chronic conditions (P < 0.05).

Conclusions
Vaccination history, age, health condition, and frequency of colds were important factors affecting the seroconversion rate of the influenza vaccine in human. There is a need for developing optimized vaccination strategies for vulnerable groups to improve the efficacy of influenza vaccines in human.
Nocardia caishijiensis infection: a case report and review of the literature
Authors: Malaguez Webber Fabricio , Nachiappan Arun , Lau Freddy Duarte , Costello Christie , Zane Saul 
Published: April 2023

Abstract
Background
Nocardia caishijiensis is a rare soil actinomycete first described in Anhui province, China, in 2003. There has been only one reported instance of human infection caused by this species in the current literature.

Case presentation
We present a case of pulmonary nocardiosis caused by Nocardia caishijiensis in a fifty-two-year-old man with human immunodeficiency virus infection and concomitant use of high-dose dexamethasone for cervical myelopathy, treated successfully with amikacin and thrimetroprim-sulfametoxazole, antibiotic resistance pattern was obtained, although interpretation may be limited.

Conclusion
To our knowledge, this is the first reported case of Nocardia caishijiensis infection in humans in North America and the second one in the literature, this pathogen should be recognized as a potentially rising etiology of nocardiosis, especially in solid organ transplant recipients. This has a rising importance as the survival for solid organ recipients continue to rise with advance in transplant medicine leading to increased life expectancy in this particularly susceptible group.
Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review
Authors: Chen Ning-Xin , Wang Ming-Liang , Wang Hai-Xing , Zeng Meng-Su 
Published: April 2023

Abstract
Objective
The purpose of this study was to evaluate the CT and MRI findings, clinicopathologic features, and differential diagnosis of Sclerosing angiomatoid nodular transformation (SANT).

Methods and materials
Seven men and seven women with pathological diagnoses of SANT were included in this retrospect study. Patients underwent at least one radiological examination before surgery. The number, shape, margin, size, attenuation, signal intensity, homogeneity, and enhancing pattern of the lesion were evaluated by two abdominal radiologists independently. Immunohistochemistry reports were available for 11 patients. The immunoreactivity to the vascular markers CD8, CD31, and CD34 was assessed.

Results
The 14 SANT patients (7 men, 7 women; mean age, 43.5 years; age range, 24–56 years) presented with a single lesion and showed no specific clinical symptoms. Among 14 patients, 12 patients underwent MR scan, 5 patients underwent CT scan and 3 patients underwent PET-CT. On CT, all 5 lesions showed hypodensity on non-contrast images and spoke-wheel enhancing pattern after contrast administration, and calcification was observed. On T2WI, 10 cases(83.3%)showed hypointensity and 2 cases (16.7%) showed hyperintensity with central hypointensity. On T1WI, 10 cases (83.3%) were isointense and 2 cases (16.7%) were slightly hypointense. 10 cases (83.3%) showed hypointensity on DWI and 2 cases (16.7%) showed slightly hyperintensity on DWI. After contrast administration, all 12 lesions showed progressive enhancement. 18 F-fluorodeoxyglucose (FDG) uptake in the tumor was seen in all three cases that underwent PET-CT. The maximum standardized uptake value (SUVmax) was 4.5, 5.1, and 3.8 respectively.

Results
Apart from the progressive spoke-wheel enhancing pattern, DWI and ADC findings will add value to the diagnosis of SANT.
Texting for life: a mobile phone application to connect pregnant women with emergency transport and obstetric care in rural Nigeria
Authors: Okonofua Friday , Ntoimo Lorretta , Johnson Ermel , Sombie Issiaka , Ojuolape Solanke , Igboin Brian , Imongan Wilson , Ekwo Chioma , Udenigwe Ogochukwu , Yaya Sanni , Wallis Anne B. , Adeniran Joy 
Published: April 2023

Abstract
Background
Difficulty in transportation to access skilled providers has been cited repeatedly as a major barrier to utilization of emergency obstetric care in Nigeria.

Objective
The objective of this paper is to describe the design, implementation, and outcomes of a mobile phone technology aimed at rapidly reaching rural Nigerian women who experience pregnancy complications with emergency transportation and access to providers.

Method
The project was implemented in 20 communities in two predominantly rural Local Government Areas (LGAs) of Edo State, in southern Nigeria, as part of a larger implementation project aimed at improving the access of rural women to skilled pregnancy care. The digital health innovation named Text4Life, allowed women to send a brief message from their mobile phone to a server linked to Primary Health Care (PHC) facilities and to access pre-registered transport owners. Pregnant women were registered and taught to text short messages to a server from their mobile phones or those of a friend or relative when they experience complications.

Results
Over 18 months, 56 women out of 1620 registered women (3.5%) texted the server requesting emergency transportation. Of this number, 51 were successfully transported to the PHC facilities, 46 were successfully treated at the PHC, and five were referred to higher-level care facilities. No maternal deaths occurred during the period, while four perinatal deaths were recorded.

Conclusion
We conclude that a rapid short message sent from a mobile phone to a central server and connected to transport providers and health facility managers is effective in increasing the access of pregnant women to skilled emergency obstetric services in rural Nigeria.
Clinical benefit of subsequent chemotherapy after drug-induced interstitial lung disease in pancreatic cancer patients: a multicenter retrospective study from Japan
Authors: Irie Hiroki , Suzuki Rei , Okubo Yoshinori , Asama Hiroyuki , Konno Naoki , Noguchi Yuki , Watanabe Ko , Shibukawa Goro , Imamura Hidemichi , Takagi Tadayuki , Sugimoto Mitsuru , Sato Yuki , Nakamura Jun , Kato Tsunetaka , Hashimoto Minami , Yanagita Takumi , Hikichi Takuto , Ohira Hiromasa 
Published: April 2023

Abstract
Purpose
Drug-induced interstitial lung disease (ILD) is not a rare adverse event in the current chemotherapy strategy for pancreatic ductal adenocarcinoma (PDAC). Thus, we aimed to find the optimal management for PDAC patients with a history of ILD induced by a gemcitabine-based regimen.

Methods
We conducted a multicenter retrospective study. The primary endpoint was the overall survival (OS) of patients who underwent either S-1 monotherapy or FOLFOX after the onset of ILD. Toxicity data was also analyzed in the 2 groups.

Results
Twenty-four patients were diagnosed with ILD and 17 patients who received subsequent chemotherapy were enrolled in the study. Among 17 patients who were managed with subsequent chemotherapy after recovering from ILD, we did not observe significant difference in OS between S-1 and FOLFOX (290.0 days vs. undefined, p = 0.39). Relapse of drug-induced ILD was not observed in all cases during the course. Overall, severe adverse events (CTCAE Grade 3 or 4) were observed in 3 patients (23.1%) in S-1 treatment group and 1 patient (25.0%) in FOLFOX treatment group (p = 0.93).

Conclusions
S-1 monotherapy and FOLFOX are comparable as the subsequent chemotherapy after gemcitabine-based chemotherapy-induced ILD in unresectable PDAC.
Elemental profiles in distant tissues during tumor progression
Authors: Salles Samella , Salles Rebecca , Pavão Mauro S. G. , Cardoso Simone C. , Stelling Mariana P. 
Published: April 2023

Abstract
Background
Essential elements have functions in tumor progression by promoting protumoral cellular processes, such as proliferation, and migration, among others. Obtaining an understanding of how these elements relate to tumor progression processes is of great importance for research. Elemental profile studies in distant tissues, which can be modulated by tumor cells to promote metastasis, have not been sufficiently investigated. The main goal of this study is to evaluate multielemental distribution during tumor progression, focusing on tumor tissue and distant tissues that may be affected.

Methods
Tumor progression in vivo was simulated by inoculating C57BL/6 mice with Lewis Lung Carcinoma (LLC) cells. Samples of the primary tumor and distant tissues were collected during 5 weeks of tumor progression for the control and experimental (tumor-bearing) groups. The biological samples were analyzed using the synchrotron radiation X-Ray fluorescence technique. Data on the concentration of P, S, K, Ca, Mn, Fe, Cu, and Zn in the samples were obtained and statistically analyzed to evaluate the distribution of the elements during tumor progression in the primary tumor as well as distant tissues.

Results
It was possible to observe significant changes in the concentrations’ distribution of P, S, K, Ca, Mn, Fe, and Cu in distant tissues caused by the presence of tumor cells. It was also possible to detect a greater similarity between tumor tissue (which has the lung as tissue of origin) and a tissue of non-origin, such as the liver, which is an unprecedented result. Moreover, changes in the distributions of concentrations were detected and studied over time for the different tissues analyzed, such as primary tumor, liver and lung, in Control and Tumor groups.

Conclusions
Among other results, this paper could explore the modulation of distant tissues caused by the presence of a primary tumor. This could be achieved by the evaluation of several elements of known biological importance allowing the study of different biological processes involved in cancer. The role of essential elements as modulators of the tumor microenvironment is a relevant aspect of tumor progression and this work is a contribution to the field of tumoral metallomics.