bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microclimate adaptability analysis of waterfront traditional villages: a case study of Mingyuewan Village in Suzhou
Authors: Zang Hui Yi , Hsieh Chun-Ming , Cang Yun , Gu Mengying 
Published: August 2023

Abstract
Traditional villages contain human beings adapting to the natural environment and spontaneously forming a living environment in the process of their evolution. However, with the frequent occurrence of harsh weather in recent years, the livability of traditional villages is also facing challenges. In order to improve the climatic adaptability of traditional villages, scholars have proposed many methods, but there is a lack of research on the spatial microclimate adaptation of traditional villages based on the perspective of spatial accessibility. This paper selects typical traditional villages in the Taihu Lake Basin, analyzes spatial accessibility and CFD numerical simulation comfort by spatial syntax from the two levels of village and iconic nodes, and discusses the correlation between spatial accessibility and climate comfort. Also, the study concludes the following: (1) The overall integration degree of Mingyuewan Village is not high, and the overall accessibility is poor. (2) The correlation between wind environment and spatial accessibility is weak. The thermal environment is associated with spatial accessibility. Comfort is strongly correlated with the degree of spatial accessibility. This paper proposes to consider the lake surface to dominate the seasonal wind, reserve windward outlets, and add green plants and shade facilities in green public open spaces.
The new ‘surface storage’ concept versus the old ‘sponge effect’ concept: application to the analysis of the spatio-temporal variability of the annual daily maximum flow characteristics in southern Quebec (Canada)
Authors: Assani Ali Arkamose , Zeroual Ayoub , Kinnard Christophe , Roy Alexandre 
Published: August 2023

AbstractThis study confronts the new concept of ‘surface storage’ with the old concept of ‘sponge effect’ to explain the spatio-temporal variability of the annual daily maximum flows measured in 17 watersheds of southern Quebec during the period 1930–2019. The new concept takes into account the hydrological impacts of wetlands and other topographic components of the landscape (lakes, depressions, ditches, etc.) while that of the sponge effect only takes into account the hydrological impacts of wetlands. With regard to spatial variability, the area of wetlands and other water bodies is the variable best correlated negatively with the magnitude but positively with the duration of flows. As for the temporal variability, the application of the long-term trend tests revealed a significant increase in the magnitude and, to a lesser extent, the duration of the flows occurring in the watersheds of the north shore characterized by a greater area of wetlands and other water bodies (&gt;5%). This increase is explained by the fact that the storage capacity of these land types, which remains unchanged over time, does not make it possible to store the surplus runoff water brought by the increase in rainfall during the snowmelt season.
Phosphorus removal and recovery from anaerobic bioreactor effluent using a batch electrocoagulation process
Authors: Bhoi Gyana Prakash , Singh Kripa S. , Connor Dennis A. 
Published: August 2023

Abstract

A batch monopolar electrocoagulation system was developed and studied for the removal of phosphorus from anaerobic bioreactor effluent using iron as an electrode material. The study focused on the optimization of the independent variables, such as initial pH, retention time (RT), current density (CD) and inter-electrode distance (IED) using the response surface methodology (RSM) to maximize the removal of total phosphorus (TP). A quadratic model was fitted to the experimental data for TP removal. The optimal parameters were found to be pH of 6.75, RT of 11.06 min, CD of 300 A/m2, and inter-electrode distance of 1.5 cm resulting in 98.05% TP removal and energy consumption of 1.28 kWh/m3. A kinetic study for TP removal revealed that at optimal conditions, removal followed first-order kinetics (K = 0.185 m/min). Phosphorus was recovered from the post-precipitated sludge through combustion at 900 °C followed by acid leaching with sulfuric acid. Acid leaching tests were carried out with sulfuric acid for the post-precipitated sludge obtained at the optimum conditions. It resulted in around 91% of phosphorus recovery at a liquid-to-solid ratio of 100 mL/g.
Exploring Mechanisms of Houshiheisan in Treating Ischemic Stroke with
Network Pharmacology and Independent Cascade Model
Authors: Cao Bo , Jin Jiao , Tang Zhiyu , Luo Qiong , An Jinbing , Pang Wei 
Published: August 2023

Background:
Houshiheisan (HSHS) has been effective in the treatment of ischemic
stroke (IS) for centuries. However, its mechanisms are still underexplored.

Objective:
The objective of this study is to identify the active ingredients and mechanisms of
HSHS in treating IS.

Methods:
We searched the main active compounds in HSHS and their potential targets, and key
targets related to IS. Based on the common targets of HSHS and IS, we further expanded genes by
KEGG database to obtain target genes and related genes, as well as gene interactions in the form of
A→B, and then constructed a directed network including traditional Chinese medicines (TCMs),
active compounds and genes. Finally, based on enrichment analysis, independent cascade (IC)
model, and molecular docking, we explored the mechanisms of HSHS in treating IS.

Results:
A directed network with 6,348 nodes and 64,996 edges was constructed. The enrichment
analysis suggested that the AGE pathway, glucose metabolic pathway, lipid metabolic pathway, and
inflammation pathway played critical roles in the treatment of IS by HSHS. Furthermore, the gene ontologies
(GOs) of three monarch drugs in HSHS mainly involved cellular response to chemical stress,
blood coagulation, hemostasis, positive regulation of MAPK cascade, and regulation of inflammatory
response. Several candidate drug molecules were identified by molecular docking.

Conclusion:
This study advocated potential drug development with targets in the AGE signaling
pathway, with emphasis on neuroprotective, anti-inflammatory, and anti-apoptotic functions. The
molecular docking simulation indicated that the ligand-target combination selection method based
on the IC model was effective and reliable.
The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System
Authors: Hao Xuechao , Yang Yaoxin , Liu Jin , Zhang Donghang , Ou Mengchan , Ke Bowen , Zhu Tao , Zhou Cheng 
Published: August 2023

Abstract:Rhythmic eupneic breathing in mammals depends on the coordinated activities of the neural system that sends cranial and spinal motor outputs to respiratory muscles. These outputs modulate lung ventilation and adjust respiratory airflow, which depends on the upper airway patency and ventilatory musculature. Anesthetics are widely used in clinical practice worldwide. In addition to clinically necessary pharmacological effects, respiratory depression is a critical side effect induced by most general anesthetics. Therefore, understanding how general anesthetics modulate the respiratory system is important for the development of safer general anesthetics. Currently used volatile anesthetics and most intravenous anesthetics induce inhibitory effects on respiratory outputs. Various general anesthetics produce differential effects on respiratory characteristics, including the respiratory rate, tidal volume, airway resistance, and ventilatory response. At the cellular and molecular levels, the mechanisms underlying anesthetic-induced breathing depression mainly include modulation of synaptic transmission of ligand-gated ionotropic receptors (e.g., γ-aminobutyric acid, N-methyl-D-aspartate, and nicotinic acetylcholine receptors) and ion channels (e.g., voltage-gated sodium, calcium, and potassium channels, two-pore domain potassium channels, and sodium leak channels), which affect neuronal firing in brainstem respiratory and peripheral chemoreceptor areas. The present review comprehensively summarizes the modulation of the respiratory system by clinically used general anesthetics, including the effects at the molecular, cellular, anatomic, and behavioral levels. Specifically, analgesics, such as opioids, which cause respiratory depression and the “opioid crisis”, are discussed. Finally, underlying strategies of respiratory stimulation that target general anesthetics and/or analgesics are summarized.
Design and Synthesis of Gefitinib Derivatives as Potential Drugs fo r
Cancer Treatment: Antiproliferative Activity, Molecular Docking, and
ADMET Prediction
Authors: Ma Xiaoyan , Shan Min , Lu Yunlong 
Published: August 2023

Background:
Non-small cell lung cancer is one of the most common cancers worldwide, and
targeted chemotherapy has become a kind of the main treatment. Gefitinib, the most widely studied targeted
agent in non-small cell lung cancer, is an orally active tyrosine kinase inhibitor. However, gefitinib
inevitably generates acquired drug resistance, leading to treatment failure.

Objective:
A new class of compounds containing 4-anilinoquinazoline lead structure was designed and
synthesized by modifying the structure of gefitinib. These compounds are expected to exert better anticancer
activity and better binding to the EGFR-TK domain, enrich the structure of 4-anilinoquinazoline
derivatives and inspire further structural modifications.

Methods:
The antiproliferative activity of nine derivatives was determined in three cancer cell lines
(A549, PC9, and HepG2) using the MTT method. The ADMET profile of all compounds was predicted,
and the binding affinity of the compounds (5 and 6) to EGFR was predicted by Schrödinger. In addition,
the effect of these compounds (3-6) in inducing apoptosis in HepG2 cells was also studied.

Results:
Four (3, 5, 6 and 9) of the newly synthesized derivatives exhibited superior antiproliferative
activity against A549 to gefitinib (IC50 = 12.64 ± 3.59 μM), with compound 5 having the best activity
(IC50 = 7.39 ± 1.24 μM). Moreover, the ability of compounds (3-6) to induce HepG2 cell apoptosis was
significantly better than that of gefitinib.

Conclusion:
Nine structures (compounds 2-10) were synthesized and characterized, and compound 5 had
the best antiproliferative activity. Compound 3 possessed the best ability to induce HepG2 apoptosis.
Also, ADMET calculations were performed in silico, and the results revealed that compound 3 has more
suitable characteristics as a potential drug candidate.
Content and Quality of Mobile Apps for the Monitoring of Musculoskeletal or Neuropathic Pain in Australia: Systematic Evaluation
Authors: Simmich Joshua , Ross Megan Heather , Andrews Nicole Emma , Vaezipour Atiyeh , Russell Trevor Glen 
Published: August 2023

Abstract

Background
Mobile apps offer a potential mechanism for people with persistent pain to monitor pain levels conveniently within their own environment and for clinicians to remotely monitor their patients’ pain. However, the quality of currently available apps and the usefulness of included features from a clinical perspective are not known.

Objective
The aim of this study was to examine the content and quality of currently available smartphone apps designed for monitoring the intensity or presence of musculoskeletal or neuropathic pain.

Methods
A systematic search was performed in the Australian Apple and Google Play stores. Apps were included if they were designed to monitor the intensity or presence of musculoskeletal or neuropathic pain and were available in the English language within the Australian app stores. Data pertaining to the intended use of the app and clinical population were extracted by using a custom-designed data extraction form, and app quality was assessed by using the 23-item Mobile App Rating Scale.

Results
Of the 2190 apps screened, 49 met the inclusion criteria. Apps were primarily designed for adult users (36/49, 73%) with nonspecific musculoskeletal or neuropathic pain conditions, arthritis, and joint pain. All apps monitored pain intensity, with almost half (23/49, 47%) also specifying pain location. Overall, the mean quality scores from the Mobile App Rating Scale ranged from 1.5 to 4.4 (out of 5.0). Between 20% (10/49) and 22% (11/49) of apps involved clinicians, consumers, or both in their development, and 20% (10/49) had published literature related to the development or use of the app in clinical scenarios. Although 71% (35/49) had data sharing features, only 5 apps enabled client-clinician communication through the app.

Conclusions
The overall quality of mobile apps that are currently available for monitoring pain intensity is acceptable. Presently, mobile apps for remote pain monitoring lack functionality for clinicians to view data between consults. Both users and clinicians should be aware of the limitations of these apps and make informed choices in using or recommending apps that best suit the clinical need.
Parental Approach to Accompanying Children's Learning in the Family in RW II, Parak Gadang Timur Sub-District, Padang Timur District, Padang City
Authors: Defita Annisa Ayu , Jamaris Jamaris 
Published: August 2023

At this time, children really need to be given special attention in studying at home, because children are often engrossed in their own world, such as playing with friends, watching television, using gadgets, so often if parents don't monitor their children, children will forget. to study at home. Especially now that students are required to study from home. Therefore, various approaches are needed so that children want to obey what their parents say. Research using qualitative research that seeks to interact with research subjects naturally or naturally. The case study approach that researchers use is to find out about the parental approach in accompanying children in family learning in RW II, Parak Gadang Timur Village, Padang Timur District, Padang City. In the research conducted, there are several parental approaches in accompanying children's learning in families where parents act as educators and children as students at home. This is because the family is the center of children's education from an early age.Keywords: Parental approach, Child, Study
Indonesian Subtitling Translation Techniques in Muhsin and Mahasin Arabic Cartoons: A Descriptive Study Oriented to Newmark Theory
Authors: Kholis Muhammad Nur , Ayu Dika , N Nadhifa , N Hafidah , Hakimmudin W , Luthfi M 
Published: August 2023

The purpose of the study was to identify and describe the translation techniques, methods and ideologies used in translating Arabic cartoon subtitles Muhsin and Mahasin versions of the Youtube channel SFH channel and describe the quality of the translation as the impact of the techniques, methods, and ideologies applied, in terms of accuracy, acceptance and ,readability. This research uses qualitative approaches using qualitative descriptive methods. Included in the study data are Arabic video subtitles Muhsin and Mahasin, while the data sources are muhsin videos and Mahasin link versions https://youtu.be/PZ3DPvdvVdI. The data collection technique used is scriptwriting. After the data collection process, analysis is also carried out. The findings of the study showed that there are six kinds of translation techniques. Based on the dominant techniques that occur, translators tend to use communicative translation methods and domestication as their ideology. Then, the impact of the application of translation techniques, methods and ideologies on the quality of translation as a whole has accuracy, acceptance, and readability. This shows the quality of good translation.
Web-Based Sales Application Using Selection Sort and Sequential Search Algorithms at Mba Tik Stores
Authors: Saputra Muhammad Hanafi , Kusniyati Harni 
Published: August 2023

Toko Mba Tik merupakan salah satu toko yang melayani penjualan berbagai jenis kebutuhan kerumahan seperti beras, gula, jajanan, sabun dan lain-lain, serta beberapa jenis barang dalam skala besar dan juga kecil. Saat ini Toko Mba Tik memiliki sistem transaksi penjualan dan pembelian yang masih menggunakan sistem manual yaitu dengan melakukan pencatatan di dalam buku besar. Untuk sebagai pemecahnya, dirancangnya suatu aplikasi atau sistem informasi penjualan yang berbasis web yang diharapkan akan dapat membantu dalam memproses dan menyimpan data (laporan) dengan cepat, ringkas, dan rapih sekaligus menghemat waktu dan uang. Sistem Informasi Penjualan ini nantinya akan menggunakan Algoritma Selection Sort dan Sequential Search. Penggunaan Algortima Selection Sort berfungsi untuk mengurutkan data dari nilai terkecil ke terbesar atau sebaliknya, sedangkan untuk penggunaan Algoritma Sequential Searching berfungsi untuk mendapatkan atau mencari suatu informasi data dapat lebih mudah dan cepat. Setelah dilakukan 2 kali percobaan pengujian pencarian data dengan metode Sequential Search, pengujian kecepatan pencarian dengan microtime menunjukkan bahwa Algoritma Sequential Search memiliki kinerja yang cepat, dengan rata-rata waktu pencarian sekitar 0,002 detik untuk jumlah data yang tidak terlalu besar atau terbatas.Mba Tik shop is one of the shops that sells various types of household needs such as rice, sugar, snacks, soap and others, as well as several types of goods on a large and small scale. Currently, Toko Mba Tik has a sales and purchase transaction system that still uses a manual system, namely by recording it in a ledger. As a solution, a computer-based sales information system is designed which is expected to be able to assist in processing and storing data (reports) quickly, concisely and neatly as well as saving time and costs. This Sales Information System will later use Selection Sort and Sequential Search Algorithms. The use of the Selection Sort Algorithm functions to sort data from the smallest to the largest value or vice versa, while the use of the Sequential Searching Algorithm functions to obtain or search for data information more easily and quickly. After conducting 2 trials of testing data search using the Sequential Search method, testing the search speed with the microtime function shows that the Sequential Search Algortima can perform searches quickly, namely an average of 0.002 seconds for data that is relatively limited or not too much.
Upaya Mengembangkan Kompetensi Guru Penggerak di Sekolah Dasar Pada Kurikulum Merdeka Belajar
Authors: Aditiya Novela , Fatonah Siti 
Published: August 2023

Curriculum changes that occurred during the Covid-19 pandemic made the government reformulate the existing national education “Kurikulum 2013” to become “Merdeka Belajar” Curriculum (independent learning). The schools and teachers became the important institutions in the Independent Learning Curriculum that focused on the character of the Pancasila Students Profile. The teacher competencies need to be improved to achieve the learning objectives through the Sekolah dan Guru Penggerak (the activator schools and teachers). The role of the activator teachers was to improve the teachers’ quality in implementing the Independent Learning Curriculum. The purpose of this study is to determine the efforts of the teachers in improving their competence through the predicate of the Activator Schools. The research was conducted referring to a descriptive qualitative approach. The research was carried out at one Activator School, which was the Elementary School 4 Koba in the Koba district. The purposive sampling technique was used. The primary data sources were obtained through observations and discussions with 7 female teachers in low and high grades. Meanwhile, the secondary data sources were obtained from the previous studies from international, Sinta 1, and Sinta 2 journal articles. The interview process was done in a semi-structured way by providing a form, then the data results were analyzed by reducing and concluding. The results of this study revealed that the activator school sought to develop learning activities that realizes the characters of Pancasila to the students. The components that needed improvements was the teachers’ ability to do innovation in the lesson plan that contains the characters of Pancasila. The concerns faced by the activator teachers was that the training activities were carried out online in a short time, that reduced the opportunity to train making indicators and the implementation. It is suggested the school look for information from relevant education agency sources.
On Lower Bounds for Maximin Share Guarantees
Authors: Hummel Halvard 
Published: August 2023

We study the problem of fairly allocating a set of indivisible items to a set of agents with additive valuations. Recently, Feige et al. (WINE'21) proved that a maximin share (MMS) allocation exists for all instances with n agents and no more than n + 5 items. Moreover, they proved that an MMS allocation is not guaranteed to exist for instances with 3 agents and at least 9 items, or n ≥ 4 agents and at least 3n + 3 items. In this work, we shrink the gap between these upper and lower bounds for guaranteed existence of MMS allocations. We prove that for any integer c > 0, there exists a number of agents n_c such that an MMS allocation exists for any instance with n ≥ n_c agents and at most n + c items, where n_c ≤ ⌊0.6597^c · c!⌋ for allocation of goods and n_c ≤ ⌊0.7838^c · c!⌋ for chores. Furthermore, we show that for n ≠ 3 agents, all instances with n + 6 goods have an MMS allocation.
PENGARUH SISTEM INFORMASI MANAJEMEN TERHADAP EFEKTIFITAS KERJA (Suatu Studi Pada Pegawai Kecamatan Rajadesa)
Authors: Puspitasari Endah , Nursolih Enjang , Rustendi Enang 
Published: August 2023

Penelitian ini difokuskan pada pengaruh sistem informasi manajemen terhadap efektifitas kerja (Suatu Studi Pada Pegawai Pegawai Kecamatan Rajadesa).
Permasalahan yang dihadapi dalam penelitian ini meliputi : 1] Bagaimana Sistem Informasi Manajemen pada Kantor Kecamatan Rajadesa?; 2] Bagaimana Efektivitas Pengelolaan Sumber Daya Manusia pada Kantor Kecamatan Rajadesa?; 3] Bagaimana pengaruh Sistem Informasi Manajemen Terhadap Efektivitas Kerja pada Kantor Kecamatan Rajadesa?. Adapun tujuan penelitian ini adalah untuk mengetahui 1] Bagaimana Sistem Informasi Manajemen pada Kantor Kecamatan Rajadesa; 2] Bagaimana Efektivitas Pengelolaan Sumber Daya Manusia pada Kantor Kecamatan Rajadesa 3] Pengaruh Sistem Informasi Manajemen Terhadap Efektivitas Kerja pada Kantor Kecamatan Rajadesa. Metode yang digunakan dalam penelitian adalah metode survey dengan pendekatan kuantitatif yaitu hasil penelitian yang kemudian diolah dan dianalisis untuk diambil kesimpulannya. Sedangkan untuk menganalisis data yang diperoleh digunakanan analisis koefisien korelasi spearment rank, determinasi, uji Hipotesis menggunakan Uji signifikansi (Uji t) dan regresi linier sederhana. Hasil penelitian membuktikan bahwa Sistem Informasi Manajemen berpengaruh terhadap efektifitas kerja pada pegawai Kecamatan Rajadesa. Artinya semakin baik sistem informasi manajemen maka efektifitas kerja akan meningkat. Sebaiknya atasan menerpakan sistem apresiasi dan penghargaan yang diberikan secara teratur sehingga akan memberikan insentif kepada karyawan untuk melakukan yang terbaik dan pencapaian tujuan akan berjalan dengan baik.