bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational sustainability schemes align with weak sustainability
Authors: Demastus James , Landrum Nancy E. 
Published: July 2023

AbstractWhile sustainability research is expansive, studies of business‐internal practices and resulting sustainability outcomes are largely unexplored. This research fills this gap by assessing the sustainability schemes that organizations internally employ to guide sustainability efforts. Content analysis is applied to 20 environmentally oriented sustainability schemes, through the triangulated lenses of strong sustainability and sensemaking theories. Each scheme is quantitatively assessed for positioning within the Stages of Sustainability model and rank abundance curves are generated to compare relative sustainability strength among the schemes for potential recommendations in practice or future research. Results show that 100% of the sustainability schemes in this study align with various forms of weak sustainability, although five commendable schemes are more advanced than the others. Given this finding, it is expected that applying the sustainability schemes from our sample in research and practice will perpetuate weak, business‐as‐usual, sustainability while prolonging the wait for strong ecological sustainability. Novel contributions of this research include empirical evidence to support claims that sustainability schemes are aligned with weak sustainability, and the identification of the sustainability strength of sustainability schemes. Additionally, numerous calls from researchers to consider sustainability strength in research are heeded. Implications for practitioners, scheme developers, and academics relate to the development of schemes, business‐internal practices, research, and teaching that aligns with ecological science‐oriented, strong sustainability instead of the current approach that aligns with weak sustainability.
Efficacy and safety of different dual antiplatelet strategies in patients undergoing percutaneous coronary intervention: A systematic review and network meta‐analysis
Authors: Wongsalap Yuttana , Kengkla Kirati , Wilairat Preyanate , Ratworawong Khemanat , Saokaew Surasak , Wanlapakorn Chaisiri 
Published: July 2023

AbstractBackgroundDual antiplatelet therapy (DAPT) is key for preventing ischaemic events post‐percutaneous coronary intervention (PCI). Various DAPT modifications like the shortened duration or P2Y12 inhibitor (P2Y12i) de‐escalation are implemented to reduce bleeding risk. However, these strategies lack direct comparative studies. This study aimed to assess the efficacy and safety of such DAPT strategies, including de‐escalated and short DAPT, in patients undergoing PCI.MethodsWe searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases for relevant randomized controlled trials (RCTs). We performed a network meta‐analysis (NMA) to estimate risk ratios (RRs) and 95% confidence intervals (CIs). The primary efficacy endpoint was major adverse cardiac events (MACEs), and the primary safety endpoint was major bleeding. Secondary endpoints included individual components of MACEs and net adverse clinical events (NACEs).ResultsA total of 17 RCTs comprising 53,156 patients (median age, 62.0 years, 24.8% female) were included. NMA suggested that de‐escalation DAPT was associated with a significantly lower risk of MACEs (risk ratio [RR] = 0.79, 95% confidence interval [CI] = 0.64–0.98), bleeding (RR = 0.63, 95% CI = 0.49–0.82), and NACEs (RR = 0.69, 95% CI = 0.60–0.79) compared with standard DAPT. Short DAPT followed by P2Y12i monotherapy exhibited a significantly decreased risk of major bleeding (RR = 0.63, 95% CI = 0.46–0.86) compared with standard DAPT.ConclusionsDe‐escalation DAPT was the most effective strategy for preventing the risk of MACEs without increasing bleeding events, while short DAPT followed by P2Y12i monotherapy was the most effective strategy for reducing the risk of bleeding among patients undergoing PCI.
Liquid‐Free, Self‐Repairable, Recyclable, and Highly Stretchable Colorless Solid Ionic Conductive Elastomers for Strain/Temperature Sensors
Authors: Zeng Wangyi , Yang Wenhao , Chai Liang , Jiang Yanxin , Deng Longjiang , Yang Guang 
Published: July 2023

AbstractSolid‐state ionic conductive elastomers (ICEs) can fundamentally overcome the disadvantages of hydrogels and ionogels (their liquid components tend to leak or evaporate), and are considered to be ideal materials for flexible ionic sensors. In this study, a liquid‐free ionic polyurethane (PU) type conductive elastomer (ICE‐2) was synthesized and studied. The PU type matrix with microphase separation endowed ICE‐2 with excellent mechanical versatility. The disulfide bond exchange reaction in the hard phase and intermolecular hydrogen bonds contributed to damage repairing ability. ICE‐2 exhibited good ionic conductivity (2.86×10−6 S/cm), high transparency (average transmittance >89 %, 400~800 nm), excellent mechanical properties (tensile strength of 3.06 MPa, elongation at break of 1760 %, and fracture energy of 14.98 kJ/m2), appreciable self‐healing ability (healing efficiency >90 %), satisfactory environmental stability, and outstanding recyclability. The sensor constructed by ICE‐2 could not only realize the perception of temperature changes, but also accurately and sensitively detect various human activities, including joint movements and micro‐expression changes. This study provides a simple and effective strategy for the development of flexible and soft ionic conductors for sensors and human‐machine interfaces.
A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females
Authors: Ahmed Aftab , Saleem Muhammad Awais , Saeed Farhan , Afzaal Muhammad , Imran Ali , Akram Sidra , Hussain Muzzamal , Khan Aqsa , Al Jbawi Entessar 
Published: July 2023

AbstractCalcium is imperative in maintaining a quality life, particularly during later ages. Its deficiency results in a wide range of metabolic disorders such as dental changes, cataracts, alterations in brain function, and osteoporosis. These deficiencies are more pronounced in females due to increased calcium turnover throughout their life cycle, especially during pregnancy and lactation. Vitamin D perform a central role in the metabolism of calcium. Recent scientific interventions have linked calcium with an array of metabolic disorders in females including hypertension, obesity, premenstrual dysphoric disorder, polycystic ovary syndrome (PCOS), multiple sclerosis, and breast cancer. This review encompasses these female metabolic disorders with special reference to calcium and vitamin D deficiency. This review article aims to present and elaborate on available data regarding the worldwide occurrence of insufficient calcium consumption in females and allied health risks, to provide a basis for formulating strategies and population‐level scientific studies to adequately boost calcium intake and position where required.
Effects of age and sex on the comorbidities of alopecia areata: A cross‐sectional hospital‐based study
Authors: Hamidpour Elham , Shakoei Safoura , Nasimi Maryam , Ghandi Narges 
Published: July 2023

AbstractBackground and AimsAlopecia areata (AA) is a common autoimmune nonscarring hair disorder with strong genetic links. It seems to be associated with several comorbidities affecting the AA treatment plan. On the other hand, the prevalence of comorbidities in different populations can be different based on genetic differences. This study aimed to clarify the association between age and sex with various comorbidities in AA patients.MethodsThis cross‐sectional study was conducted on 402 patients suffering from AA referred to our hospitals between 2018 and 2021. The clinical records of the patients were reviewed, including demographic and clinical information.ResultsThe most common diseases associated with AA were anxiety (36%), dermatitis (30%), hypothyroidism (9%), hyperlipidemia (5%), and vitamin D deficiency (4%). The most common comorbidities in AA patients over 18 years were allergic rhinitis, psychological problems, diabetes, hypertension, and hypothyroidism (p < 0.05). Hypothyroidism was more common in female patients than in male patients (p = 0.002). In contrast, hyperlipidemia was more common in male patients than in female patients (p = 0.024). There was a significant association between the severity of AA and hyperlipidemia and vitiligo (p = 0.003 and 0.045).ConclusionSex and age could affect comorbidities. The prevalence of hypothyroidism was higher in our study; it was higher in women than in men. Thyroid function tests were recommended for AA patients.
Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study
Authors: Taghipour Zahir Shokouh , Razavi Seyyed Hossein , SafiDahaj Farzan , Rahmani Koorosh , Sadeghinejad‐Alamabadi Sajad 
Published: July 2023

AbstractBackground and ObjectiveAmong cancers, gastric cancer has the fifth highest incidence worldwide and is the third most common mortality factor, which may have been due to inadequate knowledge of its molecular pathogenesis. The retinoblastoma gene (RB1), a tumor suppressor gene, may have a role in gastric cancer. This research aims to assess Rb expression as a prognostic marker to obtain more insight regarding gastric cancer.MethodsThis retrospective analytical study was done on 61 patients (45 males and 16 females) with gastric adenocarcinoma admitted from 2010 to 2012 in Shahid Sadoughi and Mortaz hospitals, Yazd, Iran. Demographic data, including age, gender, clinical signs and symptoms, and pathology reports, were retrieved from patients' hospital folders. Then, the altered Retinoblastoma gene expression was evaluated by immunohistochemistry studies. Acquired data were analyzed by SPSS software v.16. p < 0.05 was statistically considered meaningful.ResultsIn this study, the ratio of men to women was higher (2.81:1), and the mean age of patients was 62.44 years. About 90.2% of patients died during the study. There was no meaningful relationship between the presence of pRb, the intensity of staining, the percentage of staining with patients' age, gender, tumor grading, and survival rate (p > 0.05). There was only a meaningful relationship between the grade of tumors and survival rate (p = 0.039).ConclusionAltered pRB expression is not common in gastric cancer and does not impact the survival and grading of tumors. Poorly differentiated tumors had an ominous outcome with the lowest survival time.
Evaluation on social media health information communication based on machine learning technology
Authors: Lian Xiaoqing , Liang Cang , Li Jing 
Published: July 2023

AbstractSocial media is an important channel for information dissemination in today's society. All kinds of enterprises, political organization, social organizations, etc. release all kinds of information through social media. This article conducted research and analysis on information on social media and effectively managed it. Machine learning methods can effectively solve the problem of analyzing health information (HI) in social media, thereby improving analysis efficiency and accuracy. This article explored the dissemination of social media HI based on machine learning technology, elaborated on the analysis and research of social media HI dissemination, discussed the importance of social media HI for the audience, and analyzed the empowerment of machine learning in HI dissemination. Through analysis and investigation, the new social media HI dissemination has increased by 0.09% compared with the traditional social media HI dissemination pseudoscience information identification; audience involvement has increased by 0.08; audience professionalism has increased by 0.2. Introducing machine learning into the field of HI content dissemination can help achieve customized production and crowdsourcing of content, from concept to reality, and from theory to practice, and thus trigger a new content revolution, shining new youth and vitality into HI dissemination.
Linoleic acid derivatives target miR‐361‐3p/BTG2 to confer anticancer effects in acute myeloid leukemia
Authors: Liu Shili , Xu Huijuan , Li Zhen 
Published: July 2023

AbstractAcute myeloid leukemia (AML) is a deadly hematologic malignancy. In this study, miR‐361‐3p and BTG2 gene expression in AML blood and healthy specimens were analyzed using quantitative real‐time reverse transcription polymerase chain reaction. A significant negative correlation between miR‐361‐3p and BTG2 was observed. The cell viability and apoptosis were measured by CCK‐8 assay, EdU incorporation assay and flow cytometry. A dual‐luciferase reporter gene assay was performed to confirm the binding sequence between miR‐361‐3p and BTG2 messenger RNA 3ʹ‐untranslated region. 9s‐Hydroxyoctadecadienoic acid (9s‐HODE), a major active derivative of linoleic acid, reduced the viability and induced cell apoptosis of HL‐60 cells. Furthermore, the miR‐361‐3p mimics and siBTG2 reversed the above effects of 9s‐HODE. 9s‐HODE exerted an anti‐AML effect through, at least partly, regulating the miR‐361‐3p/BTG2 axis.
The product structure of squaregraphs
Authors: Hickingbotham Robert , Jungeblut Paul , Merker Laura , Wood David R. 
Published: July 2023

AbstractA squaregraph is a plane graph in which each internal face is a 4‐cycle and each internal vertex has degree at least 4. This paper proves that every squaregraph is isomorphic to a subgraph of the semistrong product of an outerplanar graph and a path. We generalise this result for infinite squaregraphs, and show that this is best possible in the sense that “outerplanar graph” cannot be replaced by “forest”.
The interplay between lipid droplets and virus infection
Authors: Qu Yafei , Wang Weili , Xiao Maggie Z. X. , Zheng Yuejuan , Liang Qiming 
Published: July 2023

AbstractAs an intracellular parasite, the virus usurps cellular machinery and modulates cellular metabolism pathways to replicate itself in cells. Lipid droplets (LDs) are universally conserved energy storage organelles that not only play vital roles in maintaining lipid homeostasis but are also involved in viral replication. Increasing evidence has demonstrated that viruses take advantage of cellular lipid metabolism by targeting the biogenesis, hydrolysis, and lipophagy of LD during viral infection. In this review, we summarize the current knowledge about the modulation of cellular LD by different viruses, with a special emphasis on the Hepatitis C virus, Dengue virus, and SARS‐CoV‐2.
Metal‐organic framework functionalized with deep eutectic solvent for solid‐phase extraction of Rhodamine 6G in water and cosmetic products
Authors: Ozalp Ozgur , Gumus Zinar Pinar , Soylak Mustafa 
Published: July 2023

An NH2‐MIL‐53(Al)‐DES(ChCl‐Urea) nanocomposite was synthesized for extraction and determination of Rhodamine (Rh) 6G from environmental and cosmetic samples. The deep eutectic solvent (DES) was prepared by mixing choline chloride and urea in a mole ratio of 1:2. NH2‐MIL‐53(Al)‐DES(ChCl‐Urea) nanocomposite was synthesized using the impregnation method at a ratio of 60:40 (w/w). The optimum conditions were determined after NH2‐MIL‐53(Al)‐DES(ChCl‐Urea) characterization was performed. The optimum conditions were determined as pH 8, adsorbent amount of 15 mg, total adsorption‐desorption time of 6 min, and enrichment factor of 20. The recovery values of the solid‐phase extraction method for water and cosmetic samples under optimum conditions were between 95% and 106%. NH2‐MIL‐53(Al)‐DES(ChCl‐Urea) nanocomposite was an economically advantageous adsorbent because of its reusability of 15 times. All analyses were performed using the ultraviolet‐visible spectrophotometer. The linear range, limit of detection, and limit of quantification of the method were 100–1000, 9.80, and 32.68 μg/L, respectively. The obtained results showed that the synthesized nanocomposite is a suitable adsorbent for the determination of Rh 6G in water and cosmetic samples. The real sample applications were verified with the high‐performance liquid chromatography system.
Predictors of Clinical Outcomes in Adult Laryngotracheal Stenosis
Authors: Singh Eshita , Hullfish Haley , Fils Aaron , Ma Ruixuan , Rosow David 
Published: July 2023

ObjectivesSequelae of laryngotracheal stenosis (LTS) can be devastating, often necessitating tracheostomy. This study aims to describe the characteristics and outcomes of patients with LTS and identify risk factors for long‐term tracheostomy dependence stratified by etiology.MethodsA retrospective chart review was performed on 215 patients diagnosed with LTS from 09/01/2011 to 12/31/2020. Patients were grouped based on the cause of LTS. Patient factors were compared to evaluate risk factors for long‐term tracheostomy dependence.ResultsOf the 215 patients, 129 (60%) were classified as iatrogenic, 41 (19%) idiopathic, 10 (4.7%) cancer treatment, 18 (8.3%) autoimmune, and 17 (8%) patients unknown. Idiopathic patients were significantly less likely to be tracheostomy‐dependent compared with iatrogenic patients (p < 0.001) and cancer patients (p < 0.05). The mortality rate did not significantly differ among the categories (p = 0.1078). Significant improvement was seen after treatment, as the median percent of stenosis at presentation was 52.5%, and the median percent of stenosis at the most recent visit was 10% (p < 0.001). The autoimmune group received the most steroid injections (mean = 6.56; SD = 11.96). The idiopathic group had the longest surgery‐free interval (mean = 30.8 months; SD = 27.7).ConclusionIatrogenic and cancer patients were more likely to be tracheostomy‐dependent. There was a significant improvement in percent and length of stenosis after treatment, with the idiopathic group having the longest surgery‐free interval. Mortality risk did not differ among the different etiologies of LTS.Level of Evidence3 Laryngoscope, 134:257–263, 2024
From Sphagnum to shrub: Increased acidity reduces peat bacterial diversity and keystone microbial taxa imply peatland degradation
Authors: Xue Wenzhi , Ma Haikun , Xiang Meichun , Tian Jianqing , Liu Xingzhong 
Published: July 2023

AbstractPeatlands store one‐third of the Earth's carbon. Human activities and climate change‐induced peatland vegetation shift from Sphagnum to shrub may lead to peatland degradation. To understand the ecology and functions of these peatlands, we collected samples from 10 peatland mosaics dominated by Sphagnums, mixed plant communities of Sphagnums, and shrubs across south China. Through sequencing the plant rhizosphere microbiome and measuring peat properties, we explored the plant–soil interactions and identified the keystone microbial taxa in peatlands of three vegetation types. Results showed that peat pH decreased along with the plant community shift from Sphagnum to shrub, which may be due to the accumulation of sulfur and phenolics. Lower pH further reduced bacterial diversity in shrub peatlands as Acidobacteriota became predominant in the keystone taxa. Overall, microbiomes in shrub peatlands showed degraded properties, such as a less stable microbial community dominated by few keystone taxa and the loss of methane‐mitigating microbes. The keystone microbial taxa in Sphagnum peatlands included microbes that utilize insoluble organic substances, mono‐ and oligo‐saccharides. Most importantly, the methanotrophic microbes that oxidize methane only appeared in the keystone taxa of Sphagnum peatlands. Mixed plant community peatlands contained the highest concentrations of iron. Slow‐growing fungi and bacteria were in the keystone microbial taxa, indicating slow decomposition rates in these peatlands. Our study suggests that human activity and climate change‐induced peatland vegetation shift from Sphagnum to shrub leads to an unstable belowground community, indicating the degraded peatland, which may exacerbate in the future.
Echo time optimization for in‐vivo measurement of unsaturated lipid resonances using J‐difference‐edited MRS
Authors: Lin Dingyi , Zhou Jiaqiang , Cao Yang , Wang Ziyan , Hsu Yi‐Cheng , Zheng Fenping , Li Hong , Sun Shuiya , Ren Hong , Deng Liping , Chen Feng , Wang Min 
Published: July 2023

AbstractPurposeMeasuring lipid composition provides more information than just total lipid content. Hence, the non‐invasive measurement of unsaturated lipid protons with both high efficiency and precision is of pressing need. This study was to optimize echo time (TE) for the best resolving of J‐difference editing of unsaturated lipid resonances.MethodsThe TE dependence of J‐difference‐edited (JDE) MRS was verified in the density‐matrix simulation, soybean oil phantom, in‐vivo experiments of white adipose tissue (WAT), and skeletal muscles using single‐voxel MEGA‐PRESS sequence at 3T. The peak SNRs and Cramér‐Rao lower bounds (CRLBs) acquired at the proposed TE of 45 ms and previously published TE of 70 ms were compared (eight pairs) in WAT, extramyocelluar lipids (EMCLs), and intramyocellular lipids (IMCLs). The lipid composition in skeletal muscles was compared between healthy males (n = 7) and females (n = 7).ResultsThe optimal TE was suggested as 45 ms. Compared to 70 ms, the mean signal gains at TE of 45 ms were 151% in WAT, 168% in EMCL, 204% in IMCL for allylic resonance, and 52% in EMCL for diallylic resonance. CRLBs were significantly reduced at TE of 45 ms in WAT, EMCL, IMCL for allylic resonance and in EMCL for diallylic resonance. With TE of 45 ms, significant gender differences were found in the lipid composition in EMCL pools, while no difference in IMCL pools.ConclusionThe JDE‐MRS protocol with TE of 45 ms allows improved quantification of unsaturated lipid resonances in vivo and future lipid metabolism investigations.
An implicit locking‐free B‐spline Material Point Method for large strain geotechnical modelling
Authors: Xie Mian , Navas Pedro , López‐Querol Susana 
Published: July 2023

AbstractThe Material Point Method (MPM) has drawn great attention in the numerical modelling of large deformation, geotechnical problems. The popularity of MPM is mainly because its formulation shares significant similarities with the Finite Element Method. In MPM, the iteration points can move independently from the mesh, allowing for the resolution of large deformation problems. However, because of this, the original MPM formulation suffers from the well‐known cell‐crossing noise and volumetric‐locking instabilities, resulting in a strongly oscillated stress field. A novel implicit locking‐free B‐spline MPM that controls stress oscillations to a negligible level is proposed in this paper. A novel, but very straightforward B‐spline shape function implementation procedure, avoids the need for a complex material point searching algorithm, providing seamless transformation from the original MPM to this robust B‐spline MPM, aiming at modelling large‐strain geotechnical problems. The newly proposed volumetric locking mitigation strategy is also very easy to implement, which facilitates the reproducibility of this research. The proposed method is validated against three numerical studies: granular column collapse experiment, slope failure and footing with large penetration. The proposed numerical method agrees well with experiments reported in the literature and previous numerical studies. Also, these numerical examples show that the proposed method provides a more prominent stress field than other available methodologies.