bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre standardisation et variation : les protestations de reconnaissance dans les lettres de Mme de Sévigné
Authors: Lignereux Cécile 
Published: September 2023

La civilité du xvii e siècle étant très normée, la rhétorique épistolaire du temps obéit sans surprise à des codes. Mme de Sévigné semble leur échapper, tant cette mère est expansive à l’excès. Et pourtant, ces excès apparents répondent en tout point aux codes explicités dans les manuels. L’article le démontre à propos des protestations de reconnaissance. Ses trois parties sont les trois éléments-clés de toute lettre de remerciement : (1) les témoignages de joie et de sensibilité ; (2) l’éloge des bienfaits reçus ; (3) l’assurance d’une gratitude éternelle (qui elle-même se décline en trois « lieux »). Il ne s’en déduit ni originalité ni conformisme. La correspondance de Mme de Sévigné illustre plutôt la marge de manœuvre considérable que permettent les modèles rhétoriques.
Se ressentir en exil et le communiquer
Authors: Peraldi-Mittelette Pierre 
Published: September 2023

À partir d’une ethnographie menée depuis 2011 auprès de Touaregs installés en France, cet article questionne le terme « diaspora » comme un outil de regroupement ethnique. Au-delà, l’emploi de ce vocable implique des tribunes où les ambiances et les représentations ont des rôles d’accélérateur de perception de soi et d’une identité partiellement mise en scène. Basée sur des interactions entre Touaregs et non-Touaregs, la réflexion portera sur la présentation d’une diaspora encore peu étudiée, puis sur l’emploi d’un terme qui a ses logiques propres parmi les membres de la communauté pour enfin saisir comment les mises en scène et les ambiances se joignent aux revendications identificatoires touarègues en France.
On a lu pour vous – Comprendre les organisations… enfin !, de Henry Mintzberg
Authors: Jézéquel Myriam 
Published: September 2023

Nous vivons dans un monde « organisé » à l’extrême, depuis notre naissance à l’hôpital jusqu’à notre cérémonie funéraire. « Entre-temps, nous sommes éduqués, employés, divertis et exaspérés par des organisations », souligne le professeur émérite Henry Mintzberg. Pour autant, que comprenons-nous vraiment de leur fonctionnement ? Analyse et synthèse.
Disséquer les mécanismes de la polarisation
Authors: Venne Jean-François 
Published: September 2023

Le marketing peut-il aider à mieux prévenir la polarisation et la radicalisation ? Cette question intrigante fait l’objet d’un récent numéro spécial du Journal of Public Policy & Marketing codirigé par un professeur et une chargée de cours de HEC Montréal.
Les figures de l’emprise groupale
Authors: Chouvier Bernard 
Published: September 2023

Si la destructivité est à l’œuvre dans les groupes spontanés, elle n’en est pas moins active dans les groupes institués. L’Église prise pour modèle par Freud dans la Massenpsychologie a développé une violence radicale envers les hérésies, tout au long de son implantation temporelle. De même que dans le champ politique, le couple idéalisation-persécution est au centre du fonctionnement groupal. Lorsque l’individu entre à l’intérieur d’un groupe à croyance extrême, il est soumis à une sujétion progressive qui s’apparente à un véritable processus d’aliénation. Une relation d’emprise totale s’instaure entre le nouvel adepte, le chef et les membres de la communauté autour des positions dogmatiques avancées. L’énergumène représente l’une des figures les plus radicales, dans la mesure où il s’engage totalement dans la fureur fanatique. La recherche du martyre conduit nombre d’adeptes au sacrifice selon le modèle d’une auto-apocalypse programmée. De retour du djihad, certains militants s’engagent dans la repentance. Soit ce mouvement est une dissimulation, soit une réelle prise de conscience. On constate également l’apparition d’une théorie de l’attentisme : un repli communautaire pour se préparer à l’avènement futur de la société idéale.
Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies
Authors: Berardo Andrés , Bacaglio Cristian R. , Báez Bárbara B. , Sambuelli Rubén , Sheikh Kazim A. , Lopez Pablo H. H. 
Published: September 2023

JOURNAL/nrgr/04.03/01300535-202404000-00035/inline-graphic1/v/2023-09-09T133047Z/r/image-tiffAnti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrè syndrome, mostly related to halted axon regeneration. Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair inin vitroandin vivoparadigms of axon regeneration. These effects involve the activation of the small GTPase RhoA/ROCK signaling pathways, which negatively modulate growth cone cytoskeleton, similarly to well stablished inhibitors of axon regeneration described so far. The aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632, a selective pharmacological inhibitor of ROCK, in a mouse model of axon regeneration of peripheral nerves, where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated fibers. Our results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of Y-27632. Treatment with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous sensitivity. In contrast, the same dose showed toxic effects on the regeneration of myelinated fibers. Interestingly, scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only Y-27632. Overall, these findings confirm thein vivoparticipation of RhoA/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal antibody. Our findings open the possibility of therapeutic pharmacological intervention targeting RhoA/Rock pathway in immune neuropathies associated with the presence of anti-ganglioside antibodies and delayed or incomplete clinical recovery after injury in the peripheral nervous system.
Diagnostic value of WB-DWI versus 18F-FDG PET/CT for the detection of multiple myeloma
Authors: Zhang Bei , Zhang Li , Bian Bingyang , Lin Fang , Zhu Zining , Wang Jiping 
Published: September 2023

Abstract

Background:
Whole-body diffusion-weighted imaging (WB-DWI) is commonly used for the detection of multiple myeloma (MM). Comparative data on the efficiency of WB-DWI compared with F-18 fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography (18F-FDG PET/CT) to detect MM is limited.

Methods:
This was a retrospective, single-center study of 22 patients with MM enrolled from January 2018 to December 2019. All patients underwent WB-DWI and 18F-FDG PET/CT. Pathological and clinical manifestations, as well as radiologic follow-up, were used for diagnosis. The overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of both methods were compared. The apparent diffusion coefficient (ADC) values of MM lesions and false-positive lesions were estimated.

Results:
A total of 214 MM bone lesions were evaluated. There was no significant difference in the accuracy of WB-DWI and PET/CT (86.92 versus 88.32%). Though WB-DWI had a higher sensitivity (99.26% versus84.56%) and PET-CT had a higher specificity (96.10% versus 64.56%), these differences were not statistically significant. There was a statistically significant difference in PPV (83.33% versus 96.64%) and NPV (98.08% versus 77.89%) of WB-DWI and PET/CT, respectively. The ADC value for MM lesions was significantly lower than that for false-positive lesions (P < 0.001). Receiver operating curve analysis showed that the AUC was 0.846, and when the cut-off value was 0.745 × 10-3 mm2/s, the sensitivity and specificity were 86.3 and 83.4%, respectively, which distinguished MM lesions from non-MM lesions.

Conclusion:
WB-DWI and PET-CT scans have similar overall accuracy for detecting MM lesions. The higher PPV of PET-CT and NPV of WB-DWI make them complementary imaging modalities. The ADC value for MM lesions is significantly lower than that for false-positive lesions. An ADC cutoff value of 0.745 × 10-3 mm2/s results in sensitivity and specificity of 86.3 and 83.4%, respectively.
Second stem cell transplantation for treatment of relapsed/refractory multiple myeloma after first autologous stem cell transplant: A 15-year retrospective institutional analysis
Authors: Yadav Neha , Mirgh Sumeet P. , Aggarwal Mukul , Agrawal Narendra , Mehta Pallavi , Khushoo Vishvdeep , Kapoor Jyotsna , Bhatia Niharika , Agrawal Pragya , Ahmed Rayaz , Bhurani Dinesh 
Published: September 2023

Abstract

Background:
Multiple myeloma remains an incurable disease, with the majority of patients relapsing after autologous stem cell transplant (ASCT). After relapse, second transplant remains one of the therapeutic options, along with novel agents.

Methods:
We reviewed the data of our patients who underwent ASCT for myeloma (N = 202) over the last two decades (2004–2019). Of these, 12 patients underwent a second transplant.

Results:
Out of 12 patients, nine underwent second autologous stem cell transplant, whereas three received an allogeneic stem cell transplantation (Allo-SCT). Median progression-free survival (PFS) after the first ASCT was 32 months (5–84 months). Median interval between both the transplants was 35 months (4–159 months). Median age of our cohort which underwent second transplant was 56 years. Overall response rate (ORR) post-second transplant on day +100 was 83.3%, without any transplant-related mortality (TRM). With the use of preemptive plerixafor, none of our patients required a second day for stem cell harvest. Median CD34 dose of stem cells infused was 4.11 × 106/kg. Similar to the first ASCT, the median time to neutrophil and platelet engraftment was 11 and 12 days, respectively. At a median follow-up of 41 months, estimated 3-year PFS and overall survival (OS) was 37% ± 15% and 63% ± 15%, respectively.

Conclusion:
Among all relapsed myeloma patients who were transplant eligible, 11% underwent a second transplant. Second transplant is well tolerated with similar time to engraftment after first ASCT. Hence, we believe that second transplant is a feasible, cost-effective option in a resource-limited setting, which should be more widely utilized.
Implications of m eaninglessness i n a nxiety
Authors: Antonescu Florena , Sandu Mihaela Luminita 
Published: September 2023

The purpose of this paper is to analyze from an existential point of view the sources of anxiety and depression of modern man.Over time, both anxiety and depression have been lived and approached as one of the individual's maladaptations to the outside world, as its inability to create a balance between the outside world and the inner world. Every citizen of our society realizes, based on his own experience as well as by observing his peers, that anxiety and depression are ubiquitous.We are becoming more and more aware not only of the obvious situations of creating anxiety and depression today, such as the threats of war, the uncontrolled atomic bomb and of the radical political and economic upheavals but also of the least obvious but extremely profound, namely inner confusion, psychological disorientation and uncertainty about acceptable standards of conduct.Despite the fact that anxiety and depression have become a central issue in some of the cultural dimensions of our existence, often, addressing the issues has been hampered by a lack of coordination between these theories and approaches. In this sense, one of the remarkable and extremely useful works in creating an integrative vision of anxiety is the work of Rollo May, „The meaning of anxiety”, which we will frequently quote in the chapter on anxiety.Thus, the paper debates and analyzes the concept of „ meaning and purpose in one's own life ” and how its existence or absence influences the individual's ability to live a state of mental balance.Throughout the paper, we will review the main approaches and theories on anxiety and depression in order to have a broader perspective on the evolution of their understanding both from the point of view of psychologically and in terms of inner life.We aim to highlight the usefulness and contribution of integrative existential analysis in psychotherapeutic support for addressing anxiety and depression.Methodological support for the connection between living the existential meaning, anxiety and depression will be addressed in the chapter destined for it by which we aim to analyze the connection between the three variables and the way they are influenced.
Requirements For the Introduction of Artificial Intelligence Technology in Teaching Kuwaiti Universities Students from The Point of View of Faculty Members
Authors: Al-Slehat Rawan Yousef , Flouh Rawan Fayyad , Almutairi Nayef Lafi , Al-Baher Ibrahim , Joma Ahlam Jameel 
Published: September 2023

The study aims to identify the requirements for the introduction of artificial intelligence technology in the teaching of teaching Kuwaiti universities students from the point of view of faculty members. (28) paragraphs and the sample consisted of (149) faculty members in teaching Kuwaiti universities, and the results showed that the study sample agreed with the requirements for introducing artificial intelligence technology in teaching university students with a degree (I agree), and the results showed statistically significant differences for the requirements for introducing Artificial intelligence technology in teaching university students is due to the variable of gender and years of experience. The most important recommendation of the study came to the need to develop the educational environment in teaching Kuwaiti universities to provide requirements for the introduction of artificial intelligence technology in the educational process in teaching Kuwaiti universities to keep pace with global developments.
Temperament types and Conflict Management Styles of School Heads in the Public Secondary Schools: An Explanatory Sequential Mixed Method Inquiry
Authors: Imperial Joebel , Madrigal Dennis 
Published: September 2023

Conflict is manageable when paired with reason and experience. Using explanatory sequential mixed-method, this study determined the extent of practice and explored the insights and experiences of school heads in conflict management styles. For the quantitative phase, frequency count, percentage distribution, mean, spearman rank correlation, and rank biserial were used. The results revealed that school heads generally practiced conflict management styles to a great extent. This means that the five conflict management styles were often observed by the school heads. Meanwhile, both temperament types and demographics do not influence conflict management styles which were also supported by the qualitative results through Lichtman's three Cs: coding, categorizing, and conceptualizing. Thus, in the practice of conflict management, school heads vary in terms of their perspectives, while reasons serve as guiding principles coupled with appropriate approaches. Moreover, it is the administrative experience that really matters in conflict management, not necessarily generational age, sex, and educational attainment. The findings suggest that reason and experience are essential factors of conflict management.
Review of Edgar Schuster's Breaking the Rules: Liberating Writers Through Innovative Grammar Instruction (2003)
Authors: Bani-Khair Baker Mohammad Jamil , Alkhalifah Ziyad khalifah 
Published: September 2023

Breaking the Rules: Liberating Writers Through Innovative Grammar Instruction (2003) is a book on teaching English Grammar, composition, and practicing language rules efficiently in a more independent and individualistic sense away from old approaches of Grammar- Translation Method that have been used since ages. Edgar Schuster is a well-known author for his great interest in studying and exploring English Grammar and mastering structures. He is also known for his influential and important works that contributed much to educational development and innovation. He has published several articles and textbooks related to Grammar instruction, language planning, and writing and composition. Schuster has a broad and long experience in teaching English in secondary schools and colleges for more than forty years, and has won many awards for his distinguished teaching and research. He has been a master teacher at Harvard university, and an author of many important and significant books On Grammar and sentence structure, such as Sentence Mastery: A Sentence-Combing Approach Level B, (1989), Grammar: Usage and Style (1965), American English Today: The tools of English (1977), and many other significant books including the name of this book reviewed in this paper.
A Tracer Study of the Graduates of Education Graduate Programs 2018-2022 of the University of Negros Occidental- Recoletos Graduate School
Authors: Gentova Cecile S. , Madrigal Dennis V. , Bual Joel M. 
Published: September 2023

This explanatory sequential inquiry determined the contribution of graduate education to the development of skills, the satisfaction with the delivery of the graduate school program and services, and the practice of graduate attributes of the graduates of education graduate programs of the University of Negros Occidental-Recoletos Graduate School. Likewise, it explored deeper insights on the quantitative data to generate a broader perspective on the graduates’ experiences on the contributions of the graduate school to the development of their skills, satisfaction with the delivery of programs and services, and graduate attribute practice. The participants were the graduates of education graduate programs during 2018-2022 and determined using purposive sampling. In data gathering, survey questionnaire and semi-structured in-depth interview were employed. In analyzing the data, mean and standard deviation were utilized in the quantitative analysis while Lichtman’s (2013) 3C’s were used in the qualitative data. The data revealed a very great extent of the contribution of graduate studies, extremely satisfied with the delivery, and a very great extent of graduate attribute practice. Meanwhile, the qualitative data presented salient findings. The graduate education experiences provide the development of their competencies, knowledge, skills, and attributes, which leads to better opportunities in their profession. Also, their satisfaction develops their attributes of humility, Christian values, integrity, love, and the quest for excellence, thus forming values essential to the practice of profession and life in general. Moreover, this study validated that tracer studies could assist the graduate school in complying with the accreditation and quality assurance measure requirements for a quality management system. Furthermore, the satisfaction of graduates encourages continual improvement towards engaging the alumni in open, mutually beneficial ways and spreading knowledge to uplift others and positively use their influence to impact the community, the country, and the world.
Impact of Parasites and Parasitic Diseases on Animal Health and Productivity
Authors: Muriu Jian 
Published: September 2023

Purpose: The aim of the study is to investigate the impact of parasites and parasitic diseases on animal health and productivity.
Methodology: This study adopted a desktop methodology. This study used secondary data from which include review of existing literature from already published studies and reports that was easily accessed through online journals and libraries
Findings: The study found that parasites and parasitic diseases have a significant impact on animal health and productivity across various species. Negative associations between parasitic infections and key indicators of health and productivity, such as weight gain, milk production, reproductive performance, wool quality, and egg quality. Animals with higher parasite burdens tend to experience slower growth rates, reduced fertility, compromised immune function, and increased susceptibility to other diseases. Additionally, parasitic infections can lead to poor feed conversion ratios, higher mortality rates, and decreased overall productivity in livestock and poultry farming operations
Unique Contribution to Theory, Practice and Policy: The study was anchored on Resource Competition Theory which was proposed by Robert M. May in 1974 and Immunopathology Theory which was proposed by Zinkernagel and Doherty in 1974. The study recommends that Governments and regulatory bodies should develop and enforce policies that promote responsible parasite control practices in livestock production.
HIỆU QUẢ MÁNG MAGO TRONG ĐIỀU TRỊ RỐI LOẠN CHỨC NĂNG KHỚP THÁI DƯƠNG HÀM
Authors: Phạm Thu Trang , Trần Thị Thanh Mai , Nguyễn Tuấn Linh , Phạm Thị Hồng Thùy 
Published: September 2023

Mục tiêu: MÔ tả sự thay đổi về mặt lâm sàng và
xquang khi điều trì rối loạn chức năng thái dương hàm bằng máng mago. Đối tượng và phương pháp nghiên cứu: Nghiên cứu được thực hiện trên 30 bệnh nhân được chẩn đoán rối loạn thái dương hàm dến khám và điều trị tại bệnh viện răng hàm mặt trung ương Hà Nội, sử dụng kết quả thăm khám và chụp xquang Conebeam City (CBCT). Kết quả: Thay đổi lâm sàng: giảm đau sau điều trị theo thang điểm VAS 2,9 ± 2,9, giảm tiếng kêu click từ 86.7% còn 43.3%, giảm tiếng lạo xạo 10% còn 6.3%, há miệng to hơn 8.5±3.9mm. CBCT: trong 18 bệnh nhân có di lệch lồi

điều trị 75% lành thương, còn 25% khÔng có sự thay đổi rõ rệt trên phim. Sự thay đổi này có ý nghĩa thống kê Với p<0,005
ĐẶC ĐIỂM VIÊM TĨNH MẠCH SAU ĐẶT CATHETER TĨNH MẠCH NGOẠI VI TRÊN NGƯỜI BỆNH TẠI BỆNH VIỆN PHỔI TRUNG ƯƠNG
Authors: Trần Thị Lý , Cao Thị Hồng Hà , Lê Văn Nhân 
Published: September 2023

Đặt vấn đề: Kỹ thuật tiêm truyền tĩnh mạch được thực hiện bằng catheter tĩnh mạch ngoại vi là phương pháp tiêm, truyền tĩnh mạch sử dụng loại kim làm bằng ống nhựa mềm luồn vào trong lòng tĩnh

mạch. Một trong những tai biến muộn hay gặp nhất là tình trạng viêm tĩnh mạch sau đặt và lưu CTMNV. Mục tiêu: MÔ tả đặc điểm viêm tĩnh mạch sau đặt catheter tĩnh mạch ngoại vi trên người bệnh tại Bệnh viện Phổi Trung ương, năm 2018. Phương pháp: Nghiên cứu mÔ tả cắt ngang. Kết quả: 341 người bệnh được lựa chọn vào nghiên cứu với 403 Catheter tĩnh mạch ngoại vi được quan sát. Tỷ lệ viêm tĩnh mạch chung sau đặt CTMNV đánh giá bằng thang điểm INS Phlebitis scale là 43,4% tính theo người bệnh và 45,2% tính theo CTMNV. Tỷ lệ viêm tĩnh mạch sau đặt CTMNV trên NB có sự thay đổi và khác nhau theo độ tuổi, giới tính, BIM, thời gian lưu catheter, vị trí đặt catheter và loại catheter.