bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of COVID-19 Diagnosis based on Symptoms
Authors: Malik Sonika , Aggarwal Tanay 
Published: June 2023

Abstract
The COVID-19 pandemic has caused a significant global impact, creating a need for accurate prediction models. Such models can inform public health policies, guide resource allocation decisions, and assist individuals and society as a whole in decision-making. Several prediction models that combine multiple features to estimate infection risk have been developed using various data sources, such as case counts, testing rates, and demographic information. These models aim to assist healthcare professionals in triaging patients, especially in resource-limited settings. Our model accurately predicted COVID-19 test results using features such as sex, age 60 years, known contact with an infected person, and the presence of initial clinical symptoms. While no prediction model is perfect, they can provide valuable insights and contribute to the ongoing efforts to mitigate the impact of COVID-19.
Brexit Impact on the UK Trade Agreements
Authors: Alali Walid Y , Ellalee Haider 
Published: June 2023

Abstract
The people of Great Britain said their word to leave the European Union. The Brexit consequences impact on international trade is negative and large. In the meantime, the ambition Great Britain post Brexit aims for new trade agreements while not explicit (clear) about the type and with whom these agreements. Meanwhile, we examine the UK options in this study, emphasising the substance of the Brexit negative trade impact on the UK and other major economic countries, including the EU. After reviewing all the alternative and potential options for UK trade agreements post-Brexit, we find no better substitutions to the EU agreement before Brexit.
JEL-Classification: E52, F13, F14
Quercetin Suppresses TNBC Cell by Targeting ORM2
Authors: Chen Zhijun 
Published: June 2023

Abstract
Background
Triple-negative breast cancer (TNBC) is known for its aggressive nature, and Quercetin (QUE) has shown potential anti-cancer effects.
Methods
We determined the IC50 of QUE for inhibiting cell viability in multiple TNBC, non-TNBC, and normal breast cell lines. We compared the expression of ORM2 in TNBC clinical samples and normal tissues. Additionally, we measured ORM2 expression in TNBC and normal breast cell lines. We determined the IC50 of QUE for inhibiting cell viability after ORM2 knockdown. An orthotopic implantation mice model was used to evaluate the treatment effect of QUE. We also conducted molecular docking and amino acid exchange validation to model the binding of QUE to ORM2. Furthermore, we performed a protein-protein interaction network analysis and GO enrichment analysis of differentially expressed genes associated with ORM2 in TNBC.
Results
QUE inhibited the viability of both TNBC and non-TNBC cell lines, but it was specifically associated with worse survival in TNBC patients. We observed higher expression of ORM2 in breast cancer cells compared to normal breast cells. Knockdown of ORM2 reduced the viability of TNBC cells. Treatment with QUE inhibited ORM2 expression and decreased viability in TNBC cells. In the animal model, QUE improved survival and downregulated ORM2 expression in tumors. Enrichment analysis provided insights into the potential functions of ORM2.
Conclusion
Our findings indicate that QUE directly inhibits TNBC cell viability through its interaction with ORM2. These results contribute to our understanding of the anti-cancer mechanisms of QUE in TNBC and highlight ORM2 as a potential therapeutic target.
Sub-optimal Breastfeeding Practices Among Women Having 24-59 Months Age Children in Dessie Zuria Woreda, Northwest Ethiopia
Authors: Chanie Muluken Genetu , Ayele Wolde Melese , Mekonen Asnakew Molla , Diamtie Yitiayish 
Published: June 2023

Abstract
Background Sub-optimal breastfeeding practice is a very important contributor to newborn and young child mortality in developing world including Ethiopia. Early and rapid quiting of breast-feeding, then by a commencement of unclean, unsound formula provision of children with very light milk contents is familiar in LMICs which results thousands of infant death. This study focused on assessing sub-optimal breastfeeding practice and determinant factors among women having 24–59 months age child in Dessie zuria woreda, Northwest Ethiopia.Methods A community based cross-sectional study design was carried out from October 21 to November 25, 2019 in Dessie Zuria Woreda Data collected from a sample of 346 respondents using simple random sampling technique to select participants of the study. Binary and Multivariable logistic regression model was used to identify predictors of suboptimal breast feeding practice using AOR with P-value < 0.05, and at 95% CI.Result Three hundred forty six participants completed the questionnaire making the response rate 98%. The overall suboptimal breastfeeding was found 46.3% at 95% CI (42.3%-50.7%). Maternal illiteracy level, number of ANC visit, use of radio and counseling during ANC visit were found preventive factors for sub-optimal breast feeding practice in the study areaConclusion The prevalence of sub-optimal breast feeding was found high magnitude. Four predictor variables that possibly reduce sub-optimal breastfeeding practice which demands an intervention by the policy makers, health care managers and health workers at each level of the health system.
Double level Code Scanning Leveraging network
virtualization to decrease risks of memory
starvation and insecure programming
Authors: Albibrahim Thikra , Hendaoui Saloua 
Published: June 2023

Abstract
This study investigates the impact of a software-defined networking (SDN) controller on resource utilization, system stability, and performance in cloud environments, with a specific focus on the deployment of machine learning techniques. The SDN controller utilizes machine learning algorithms to dynamically detect and block vulnerable and memory-intensive cloudlet codes. The results demonstrate that the deployment of machine learning in the SDN controller significantly improves resource allocation, mitigates resource contention, and reduces the risk of memory exhaustion. By accurately identifying and preventing the execution of insecure cloudlets, the machine learning-enabled SDN controller enhances system security and maintains optimal resource utilization. Moreover, the study highlights the positive influence of the SDN controller on system stability, preventing disruptive operations and minimizing the likelihood of system crashes or slowdowns.
Comparison of Swallowing Measures to Patient-Reported Dysphagia Symptoms in Assessment of Swallowing Function in Head and Neck Cancer Patients.
Authors: Delaney Timothy , McCarroll Liane , Ebersole Barbara , Palladino Olivia , Donocoff Kathleen , Lango Miriam , Liu Jeffrey C. 
Published: June 2023

Abstract
Patient-reported outcomes (PROs) such as the SWAL-QOL have been developed to assess quality of life (QOL) burden in Head and Neck Cancer (HNC) patients, while objective swallowing assessments such as the Modified Barium Swallow Study (MBSS) and Fiberoptic Endoscopic Evaluation of Swallowing (FEES) provide information about the safety and efficiency of a patient’s swallow. Using a combination of these tools may lead to better clinical outcomes.
The purpose of this study was to compare an objective measure of swallow function, the Penetration-Aspiration Scale (PAS) score obtained from MBSS/FEES data, with patient-reported dysphagia using the SWAL-QOL survey. On the SWAL-QOL, the domains of burden, desire, duration, food selection, fear, mental health, and social role were used for the Dysphagia Domain Score (DDS).
In the analysis of all patient data points, a statistically significant relationship between PAS and DDS was observed (p<.05, chi sq). When stratified by tumor site, PAS and DDS relationships were significant for oral cavity and larynx subsites. When stratified by T stage, only T4 tumors had a statistically significant relationship between PAS and DDS. Patients were also observed to have less dysphagia symptoms with elevated PAS as they were further removed from treatment.
Understanding how subjective and objective measures of swallowing function overlap will better inform the assessment of HNC patients. Further research should focus on how to incorporate these complementary assessments to better formulate clinical recommendations.
The Psychometric Properties and Performances of Teacher-Made Tests in Measuring Students’ Academic Performance in Ethiopian Public Universities: Baseline Survey Study
Authors: Kenea* Tekalign Geleta , Mikire Fisseha , Negawo Zenebe 
Published: June 2023

Abstract
All education levels today require quality tests to infer students' scores in judging the quality of teaching and learning. In this judgment, as many scholars argue, teacher-made tests (TMTs) are significant and more promissory than other tests. Besides their benefits, TMTs are prone to measurement error if they do not satisfy assumptions about the psychometric properties and performance of tests. Thus, this study aimed to survey the psychometric properties and performance of teacher-made tests (TMTs) in measuring students’ academic performance using pieces of evidence from three Ethiopian public universities. The researchers employed the post-positivist research paradigm, quantitative research approach, cross-sectional research design, purposive sampling size technique, CTT as the theoretical framework, and SPSS version 28 software as a statistical analysis tool. Empirical data reveal Ethiopian public universities' TMTs quality is below the expected CTT test item standard qualities [content validity, S-CVI=.65<.83, IC reliability, α=.57<.6-.7, difficulty (p)=.49<.5-.6, Skewness=-.300 and D=-0.01<.2], requiring curriculum developers to design test tables, teachers to demonstrate professional accountability, and course offering departments to have a TMTs validation team. Future studies need to include intervention and longitudinal evidence to clarify the association between TMTs and academic performance.
Parental Attitudes Towards STEM Scale: Development and Psychometric Properties
Authors: Alabbasi Ahmed M. Abdulla 
Published: June 2023

Abstract
This study describes the development of the Science, Technology, Engineering, and Mathematics (STEM) Scale, intended to assess parental attitudes toward school programs designed to deliver STEM, and evaluates its psychometric properties. The study group included 400 parents of students (138 males and 262 females) enrolled in STEM programs throughout the KSA. As a result of the analysis, a 40-item scale comprising four subscales was developed: (a) perceived value, (b) perceived control, (c) affective component, and (d) intention component. Exploratory and confirmatory factor analyses confirmed a four-factor structural model that had a satisfactory fit. Cronbach’s alpha of the overall scale demonstrated good internal consistency. Preliminary results suggest that parental attitudes toward the STEM scale have adequate convergent and divergent validity.
Community Attitudes Towards Condom Use and Unintended Pregnancies under Dual Modes of Sex Education in Ghana
Authors: Ocran Benedict , Alldred Pam 
Published: June 2023

Abstract
Background: Condom education campaigns that aim to prevent early and unintended pregnancies (EUPs) can be undermined by local gender norms, religious edicts, and ineffective sex education policies. This study explored community attitudes towards condom education in the context of either comprehensive sexuality education or abstinence forms of sex education in three schools in Ghana.
Methods: The study adopted a qualitative case study approach informed by in-depth interviews with programme managers and students.
Findings: Findings show that condom education is implemented alongside abstinence education through partnerships between the school and the community. The community largely rejected condom education, while some parents encouraged their daughters into consensual relationships and contraception. The church also rejected condom education, contradicting parental encouragement for contraception use for young women in consensual relationships. The interplay between poverty and gendered power dynamics puts young women at a disadvantage in decision-making on sexual practice condom use. At the same time, cultural taboos and religious norms limit condom use and put 11-15-year-olds at risk of early and unintended pregnancy (EUPs).
Conclusion:It is essential to recognise the impact that local gender, cultural and religious norms have in shaping how sexual health education is delivered and how sexual health outcomes are produced.
Effect of Supply Chain Management Practice on Operational Performance in Case of Bedele Brewery Share Company.
Authors: Hinkosa Jabessa 
Published: June 2023

Abstract
The main objective of this study was to investigate the effect of supply chain management practices on the operational performance of Beddelle Brewery Share Company. The dimensions of SCM practices examined in this study were strategic supplier partnership, customer relationship management, level of information sharing, quality of information sharing, and internal lean practice. The metric for measuring the company’s operational performance was the lead time. A quantitative research approach was used for this study to determine the effect of supply chain management practices and the operational performance of BBSc. The descriptive and explanatory research design was employed for the study. The probability sampling technique particularly the stratified and simple random sampling method was used to enable the researcher to use his discretion in selecting samples from the target population. Using a total of 33 questionnaires; the primary data was collected from 184 employees. The data was collected by using 5 point Likert Scale type questionnaire and then the collected data were analyzed using SPSS Version 25. From the result of the analysis, it was concluded that there was strongly positive and significant correlation between SCM practices and overall operational performance since the SCM practices included in this study explained 80.9% of the variability of the operational performance of the company. Based on the findings, the researcher recommended that Beddelle Brewery share company should strive to involve its key suppliers in planning and goal setting, create long-term agreement with key strategic suppliers, and interact with customers to set reliability, responsiveness, and other standard work for the organization, to be informed on the changing needs to improve their understanding with their trading partners and to work on improving quality of information sharing practices across the supply chain timely with its supplier.
SPATIAL PATTERN OF ARSENIC CONCENTRATION AND ASSOCIATED HEALTH RISK ASSESSMENT: A CASE STUDY ON GANGNI UNION OF CHUADANGA DISTRICT OF BANGLADESH
Authors: Islam Md. Nazrul , Haque Md. Inzamul , Hossain Md. Anik 
Published: June 2023

Abstract

Underground water is one of the world's most important sources of fresh drinking water. However, various contaminants mix with groundwater, such as arsenic. This study aimed to ascertain the present condition of arsenic concentration, its spatial pattern, and its relationship with depth and to assess the associated health risks in the Gangni Union in Alamdanga Thana of Chuadanga district. Systematic sampling was used to gather water samples (í µí± = 100) along with depth information from these tube wells. Water samples were analyzed with the Hach EZ, Dual-Range Arsenic Test Kit (Range: 0.00-0.5 mg/L). This study used both geostatistical (spatial autocorrelation, Hotspot analysis, and IDW) and statistical (descriptive and correlation statistics) methods. The arsenic content of the samples tested ranged from 0.0004 (mg/l) to 0.10 (mg/L). Arsenic levels in almost 42% of the samples were above the WHO standard, 21% were above the Bangladesh standard, and 37% were below both standards. With the same standard, the spatial distribution shows that 63% of the total area is arsenic contaminated. Hotspot’s analysis reveals that the central and southern northern parts of the study area are more arsenic-contaminated than the other parts. Children have a higher average daily dose (ADD) range (8.33E-06-0.00181) than adults (2.78E-06-0.0006). Similarly, the hazard quotient (HQ) value is also higher for children (0.0277-6.033) than for adults (0.0092-2.011). Finally, the Pearson correlation coefficient, r (98) =-.7580, p = 0.000, proved that there is a negative linear relationship between concentration values and depth, meaning that increasing depth will reduce arsenic contamination from tube well water.
Environmental and ecological risk assessment of municipal sewage sludge management using a sustainable solar drying system
Authors: Dramé Saly Ina , Oba Oluwasuyi Ayobami , Pasaoglulari Aydinlik Nur 
Published: June 2023

Abstract

Providing a cost-effective and suitable way for sewage sludge refinement with the purpose of reducing environmental impacts or reutilization of sewage sludge can be an important issue for researchers. This study is inclined at bringing an economical and sustainable solution to sludge management in a municipal wastewater treatment plant. Three types of sludges were collected for the experiments: raw sludge was collected during winter (R.S.), digested sludge was collected during winter (D.S.1), and digested sludge was collected during summer time (D.S.2). This study proposes replacing mechanical drying by a solar drying system. Experimental analysis was carried out to determine the total solids (TS), volatile solids (VS), heavy metals concentration, and pollution index (index of geo accumulation, contamination factor, ecological risk factor). The solar drying system was demonstrated to be very efficient with the three samples achieving a dry solid content of 96.96% for R.S., 96.75% for D.S.1, and 93.60% for D.S.2. after solar drying. While pollution index calculations showed that all three sludges present a low potential ecological risk.
Analisis Kesiapsiagaan Struktural dalam Menghadapi Bencana Berdasarkan Hospital Safety Index
Authors: Yenni Ririn Afrima , Novrikasari  , Windusari Yuanita 
Published: June 2023

ABSTRAK
Lembaga kesehatan, seperti rumah sakit harus siap menghadapi bencana sebagai dasar untuk layanan perawatan kesehatan masyarakat. Penelitian ini bertujuan untuk menganalisis kesiapsiagaan struktural rumah sakit dalam menghadapi bencana berdasarkan Hospital Safety Index. Penelitian ini adalah penelitian mix methods dengan jenis sequential explanatory design. Informan kunci terdiri dari empat orang yaitu Staf Keselamatan dan Kesehatan Kerja dan Staf Instalasi Pemeliharaan Sarana Non-Medik (IPSNM). Informan triangulasi yaitu Komite Keselamatan dan Kesehatan Kerja. Kesiapsiagaan struktural RSUP Dr. Mohammad Hoesin berdasarkan Hospital Safety Index sebesar 0,75. Wawancara mendalam menunjukkan bahwa anggaran dana, serta fokus rumah sakit dalam tahap peningkatan pelayanan kesehatan sebagai faktor penghambat untuk meningkatkan kesiapsiagaan struktural. Disarankan untuk terus meningkatkan tingkat keamanan dan kapasitas penanganan darurat dan manajemen bencana.
Kata Kunci: Kesiapsiagaan Bencana, Rumah Sakit, Hospital Safety Index
Faktor Risiko Gender, Outdoor Work, Dan Trauma Mata Dengan Kejadian Katarak
Authors: Harun Herlinda Mahdania 
Published: June 2023

ABSTRAK
Kesehatan mata penting bagi manusia sebagai informasi visual, tetapi seringkali tidak diperhatikan. Jumlahkebutaan dan gangguan penglihatan terbesar di dunia adalah katarak. Penelitian ini bertujuan untuk mengetahui risiko gender, outdoor work, dan trauma mata terhadap kejadian katarak di Balai Kesehatan Mata Masyarakat Kota Makassar. Penelitian dilaksanakan selama 2 bulan pada Maret-Mei 2017 dengan menggunakan desain penelitian case control. Pengambilan sampel dilakukan dengan cara sistematik random sampling. Jumlah sampel sebanyak 150 responden berusia â‰¥ 40 tahun dan memenuhi kriteria inklusi yang terdiri dari 75 kasus katarak dan 75 kontrol. Data dianalisis dengan ukuran Odds Ratio. Hasil penelitian diperoleh bahwa faktor yang signifikan berisiko terhadap kejadian katarak, yaitu outdoor work (OR=3,5, 95%CI:1,76-6,95), dan riwayat trauma mata (OR=3,8, 95%CI:1,31-10,98) dan jenis kelamin perempuan adalah faktor protektif terhadap kejadian katarak (OR=0,4; 95%CI:0,18-0,68). Kesimpulan penelitian ini adalah riwayat trauma mata dan outdoor work merupakan faktor signifikan berisiko terhadap kejadian katarak.
Kata kunci: Gender, outdoor work, trauma mata
189-LB: LDL Cholesterol Reduction and Cardiovascular Outcomes in High-Risk Primary Prevention Patients
Authors: NISSEN STEVEN , THE CLEAR OUTCOMES TRIAL INVESTIGATORS FOR 
Published: June 2023

Background: Current guidelines recommend reducing LDL cholesterol in patients at high risk for a first major adverse cardiovascular event (primary prevention). However, these recommendations are predominately based on clinical trials conducted many years ago. Most contemporary trials of LDL-cholesterol lowering therapies have enrolled only secondary prevention patients. Some authorities have questioned whether the benefits of cholesterol lowering exceed the harms in primary prevention patients. Currently, lipid-lowering therapies are underutilized in high-risk patients without a prior event, particularly in women and patients with diabetes. More than half of eligible patients are not currently receiving LDL-cholesterol lowering therapies.
Methods: The CLEAR Outcomes trial reported cardiovascular outcomes for bempedoic acid treatment compared with placebo in a mixed population of primary and secondary prevention patients unable or unwilling to take guideline-recommended doses of statins (N=13,970). The primary end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction (MI), nonfatal stroke, or coronary revascularization. The results of the CLEAR OUTCOMES trial were presented and simultaneously published in the NEJM on March 4. The hazard ratio for the primary end point for the full population was 0.87 (95% CI 0.79-0.96), P=0.004.
Results: In the CLEAR Outcomes trial, 4206 patients (30%) met high risk primary prevention entry criteria, two thirds with diabetes. The HR in these primary prevention patients was lower than the HR for secondary prevention patients, 0.68 (95% CI 0.53-0.87), with a significant interaction P value (0.03). The current Late Breaking Trial will report detailed results for the primary and all key secondary endpoints for the 4206 patients enrolled based on high risk primary prevention criteria. Full results will be available in mid-April for simultaneous presentation and publication during the ADA meeting.

Disclosure
S. Nissen: Research Support; Eli Lilly and Company, AbbVie Inc., AstraZeneca, Bristol-Myers Squibb Company, ESPERION Therapeutics, Inc., New Amsterdam Pharma, Novartis, Patient-Centered Outcomes Research Institute, Silence Therapeutics. For the clear outcomes trial investigators: n/a.

Funding
National Heart, Lung, and Blood Institute (K23HL153774 to J.E.T.); University of Toronto (to B.R.S.)