bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial longitudinal strain analysis in long Covid-19 syndrome
Authors: ZeinElabdeen Shimaa Gamal , Sherif Abdelsalam , Kandil Nader Talaat , Altabib Abdalaali Mohammed Omar , abdelrashid Mahmoud Abdelaziz 
Published: February 2023

AbstractIt is known that during the active course of Coronavirus disease 2019 (COVID-19), myocardial injury has an established pathological base, while its myocardial injury post-recovery is still obscured.The aim of this study was to evaluate the longitudinal left atrial strain (LAS) using speckle tracking echocardiography (STE) in COVID-19-recovered patients who are previously healthy without confounder comorbidities to detect the potential cardiac dysfunction.200 patients were prospectively included and examined 4?12 weeks after recovery from COVID-19 infection. 137 participants with comorbidities or previous history of cardiopulmonary disease were excluded from the analysis. A total of 63 patients who fulfilled our inclusion criteria were recruited into two groups according to thepresence or absence of persistent dyspnoea and exercise intolerance. Clinical, laboratory & comprehensive echocardiographic examinations were done for all. We observed that 31.7% of the previously healthy individuals developed dyspnoea & exercise intolerance post-COVID-19 infection. There were significantly impaired LAS parameters in the symptomatic group (LA reservoir, contraction & conduit strain, 22.7%, -6.6% & -16.1% versus 40%, -12%, and ? 27% in the asymptomatic group with P < 0.000). Only LA reservoir strain and LA stiffness can independently predict the development of dyspnoea & exercise intolerance post-COVID-19 at cut-off values of 30% & 24.5% respectively with a sensitivity of 90% and a specificity of 91%, P < 0.001. These impaired LAS parameters could explain the developed symptoms post-COVID-19 recovery, even before disturbed conventional diastolic echocardiographic parameters.LAS parameters are significantly associated with the developed exertional dyspnoea & exercise intolerance post-COVID-19. LA reservoir strain & LA stiffness could provide a simple, easily available tool that points to early LV diastolic dysfunction and may direct the therapy in this subset of the population.
PM2.5 exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions
Authors: Yu Donghui , Cai Wenting , Shen Tianyi , Wu Yan , Ren Chengda , Li Tingting , Hu Chengyu , Zhu Meijiang , Yu Jing 
Published: February 2023

AbstractDry eye disease (DED) is the most common disease affecting vision and quality of life. PM2.5 was a potential risk of DED. Herein, we conducted animal exposure and cell-based studies to evaluate the pathogenic effect of PM2.5 exposure on the ocular surface and DED etiological mechanisms. C57 mice were exposed to filtered air and PM2.5 aerosol. We assessed health conditions and inflammation of the ocular surface by corneal fluorescein staining and immunohistochemistry. In parallel, cultured human corneal epithelial cells (HCETs) were treated with PM2.5, followed by characterization of cell viability, intracellular ATP level, mitochondrial activities, and expression level of DED relevant mRNA and proteins. In mice, PM2.5 exposure induced severe superficial punctate keratopathy and inflammation in their cornea. In HCETs, cell proliferation and ROS generation followed dose-response and time-dependent manner; meanwhile, mitochondrial ROS (mtROS) level increased and mitochondrial membrane potential (MMP) level decreased. Inflammation cascade was triggered even after short-term exposure. The reduction of ATP production was alleviated with Nrf2 overexpression, NF-κB P65 knockdown, or ROS clearance. Nrf2 overexpression and P65 knockdown reduced inflammatory reaction through decreasing expression of P65 and increasing of Nrf2, respectively. They partly alleviated changes of ROS/mtROS/MMP. This research proved that PM2.5 would cause DED-related inflammation reaction on corneal epithelial cells and further explored its mechanism: ROS from mitochondrial dysfunctions of corneal epithelial cells after PM2.5 exposure partly inhibited the expression of anti-inflammatory protein Nrf2 led the activation of inflammatory protein P65 and its downstream molecules, which finally caused inflammation reaction.
Graphical abstract
Environmental assessment of the Ecuadorian cocoa value chain with statistics-based LCA
Authors: Avadí Angel 
Published: February 2023

Abstract
Introduction
Cocoa is one of the main crops grown in Ecuador. The agricultural area dedicated to cocoa represents the largest area dedicated to a permanent crop the country. Dry bean production has grown at an average annual rate of 15% since 2014, mainly due to yield improvements and replacement of other crops. Several varieties of cocoa are grown, but production is dominated by two main varieties: “Cacao Fino y de Aroma” and clonal varieties (dominated by CCN-51). Cocoa, mainly in monocrop systems, is mainly produced on the Ecuadorian Coast (but also in the Highlands and Amazonia). This study presents a statistics-based LCA of the Ecuadorian cocoa value chain.

Material and methods
LCIs representing the various types of systems in each link of the value chain—i.e. the various types of farming systems, processing and distribution—were constructed in terms of representative production units. Sub-chains centred on different cocoa varieties and value-adding strategies were identified. Primary and secondary data were collected for the most representative system types, as defined in the actor typologies. Primary data were obtained via field visits and surveys, while secondary data were obtained mainly from statistical datasets of the National Institute of Statistics and Census. Impacts were computed following the European Commission's Product Environmental Footprint, while soil carbon turnover was modelled using RothC.

Results and discussion
Identified types of producers are subsistence and entrepreneurial small, medium, and large. Two post-harvest strategies were modelled: a volume-oriented one and a quality-oriented one. The main sub-chains identified are the volume/commodity-oriented one (which is dominantly based on cocoa which either does not undergo post-harvest, or which undergoes volume-oriented post-harvest activities) and the quality-oriented one. Across producer types, irrigation and negative direct field emissions are the most important factors, followed in importance by total energy consumption. Post-harvest and processing activities are dominated by energy expenditures. Sub-chains feature significantly different intensity of impacts, with the volume-oriented sub-chain (i.e. those privileging quantity over quality) featuring lower impacts than the quality-oriented ones.

Conclusions
The impacts of the value chain are comparatively lower, at least regarding climate change, than in other producing countries. Its agricultural phase generally exhibits low input pressure, contributes to climate change mitigation through high C sequestration in biomass that exceeds C losses due to land use change (e.g. deforestation), and does not seem to pose an immediate threat to biodiversity. Improvement initiatives do not necessarily imply intensification of production.
Impulsivity Predicts Relapse—but Not Dropout—in Outpatients with SUD: a Longitudinal Study
Authors: Lozano-Rojas Óscar M. , Gómez-Bujedo Jesús , Pérez-Moreno Pedro J. , Lorca-Marín José Andrés , Vera Belén del Valle , Moraleda-Barreno Enrique 
Published: February 2023

AbstractThe objective of this study was to compare performance on a comprehensive impulsivity battery of SUD outpatients who dropout versus those who do not dropout and of abstainers versus relapsers at 3 and 12 months of treatment follow-up. Impulsivity was measured at the start of treatment and adherence and relapse at 3 and 12 months. The participants are 115 outpatients with SUD. Motor impulsivity (Affective Go/No Go), attentional impulsivity (Stroop), delay discounting (Monetary Choice Questionnaire; MCQ), and decision making (Iowa Gambling Task; IGT) were assessed. Impulsivity was not associated with dropout. There were no relationships between treatment outcomes and the MCQ and IGT. Stroop and affective Go-No Go were associated with relapse at 3 and 12 months. Affective motor disinhibition and cognitive disinhibition predict relapse in outpatients. No cognitive aspect of impulsiveness is related to dropout.
Effect of Whole Cluster Fermentation on Phenolics in Cold-Hardy Hybrid Wines
Authors: Gapinski Alexander D. , Horton Andrew C. , Watrelot Aude A. 
Published: February 2023

AbstractGenerally, red wines made from cold-hardy hybrid grapes have much lower tannin content than Vitis vinifera wines and they are often perceived as being of lower quality. This study evaluated the chemistry and sensory perception of whole-cluster (WC) fermented “Frontenac” and “Marquette” red wines from Iowa (F-ISU, M-ISU) and “Marquette” red wines from Minnesota (M-UMN). Three conditions were compared: Control 0% WC (w/w), 25% WC (w/w), and 50% WC (w/w). The 50% WC wines had significantly higher iron-reactive phenolics, tannin, and anthocyanin contents than control wines. The color intensity in 50% WC wines was maintained after 4 months of aging. A tasting evaluation was conducted with the “Marquette” wines from both states and untrained panelists preferred 50% WC “Marquette” wines over control wines. This study showed promising results on the use of 50% (w/w) whole clusters as a pre-fermentative technique to improve “Marquette” and “Frontenac” red wine quality.
Earliest versus other autobiographical memories of school-age children
Authors: Kangaslampi Samuli 
Published: February 2023

AbstractEarliest memories have been the topic of scientific research for over a century and seen use as tools of clinical assessment. Still, it remains unclear whether they are in some way distinct or revealing about the person reporting them. This preregistered study examined whether children’s self-reported earliest memories differ from other memories, and how their features link with mood and gender. Urban 9–13-year-old children in Finland (N = 166) reported on their earliest memory and another old autobiographical memory, and mood. Memories were coded for specificity, thematic content, social orientation, and emotional content. No differences between earliest and other memories were noted in specificity, trauma- and accident-related content, or emotional content. However, earliest memories had more play- and less visit-related content and were less likely to be social. Negative mood did not generally correlate with features of memories. Girls reported more social earliest and other memories, and more positive earliest memories. The findings are compared to research in other cultural environments. Overall, they do not support a privileged position for the earliest memory as an object of scientific research or clinical assessment.
Local structure and magnetic properties of a nanocrystalline Mn-rich Cantor alloy thin film down to the atomic scale
Authors: Smekhova Alevtina , Kuzmin Alexei , Siemensmeyer Konrad , Luo Chen , Taylor James , Thakur Sangeeta , Radu Florin , Weschke Eugen , Buzanich Ana Guilherme , Xiao Bin , Savan Alan , Yusenko Kirill V. , Ludwig Alfred 
Published: February 2023

AbstractThe huge atomic heterogeneity of high-entropy materials along with a possibility to unravel the behavior of individual components at the atomic scale suggests a great promise in designing new compositionally complex systems with the desired multi-functionality. Herein, we apply multi-edge X-ray absorption spectroscopy (extended X-ray absorption fine structure (EXAFS), X-ray absorption near edge structure (XANES), and X-ray magnetic circular dichroism (XMCD)) to probe the structural, electronic, and magnetic properties of all individual constituents in the single-phase face-centered cubic (fcc)-structured nanocrystalline thin film of Cr20Mn26Fe18Co19Ni17 (at.%) high-entropy alloy on the local scale. The local crystallographic ordering and component-dependent lattice displacements were explored within the reverse Monte Carlo approach applied to EXAFS spectra collected at the K absorption edges of several constituents at room temperature. A homogeneous short-range fcc atomic environment around the absorbers of each type with very similar statistically averaged interatomic distances (2.54–2.55 Å) to their nearest-neighbors and enlarged structural relaxations of Cr atoms were revealed. XANES and XMCD spectra collected at the L2,3 absorption edges of all principal components at low temperature from the oxidized and in situ cleaned surfaces were used to probe the oxidation states, the changes in the electronic structure, and magnetic behavior of all constituents at the surface and in the sub-surface volume of the film. The spin and orbital magnetic moments of Fe, Co, and Ni components were quantitatively evaluated. The presence of magnetic phase transitions and the co-existence of different magnetic phases were uncovered by conventional magnetometry in a broad temperature range.
Frequency reserves and inertia in the transition to future electricity systems
Authors: Ullmark Jonathan , Göransson Lisa , Johnsson Filip 
Published: February 2023

AbstractThe transition towards an electricity system that is dominated by asynchronous and non-dispatchable generators, such as wind and solar power, entails challenges related to balancing the load and, thereby, keeping the grid frequency stable. Many technologies can contribute to load balancing and frequency control. This study investigates the interactions between electricity generation and frequency control in terms of investments and operation, using cost-minimizing, linear optimization modeling. The model is applied in three different geographic cases and for four future time-points, starting off with the already existing transmission and generation capacities, so as to yield insights into different systems and different stages along the energy transition. The results show that frequency control constraints in the optimization model have a weak impact on the system composition and cost, and that batteries are important for minimizing the impact. Furthermore, inertia requirements without a reserve demand show no impact on the cost or system composition. When allowing for vehicle-to-grid from battery electric vehicles, a large proportion of stationary grid battery investments is displaced, and the impact on system cost from adding frequency control constraints is removed.
Detection and quantification of zearalenone and its modified forms in enzymatically treated oat and wheat flour
Authors: Pascari Xenia , Weigel Stefan , Marin Sonia , Sanchis Vicente , Maul Ronald 
Published: February 2023

AbstractAn analytical method for the analysis of the mycotoxin zearalenone (ZEN) and its modified forms was developed. Sample preparation was performed based on a modified QuEChERS method combined with liquid chromatography coupled to a triple quadrupole mass spectrometry detection. The method was tested for linearity, precision, limits of detection and quantification and recoveries. The evaluation of the above-mentioned parameters was performed on oat flour. The method was applied to oat and wheat flours that were submitted to an amylolytic treatment (α-amylase and amyloglucosidase), similar to the one used in the cereal-based baby food production process. A decrease in β-zearalenol (β-ZEL) and β-ZEL-14-sulfate of approximately 40% after 90 min incubation was observed, the other analytes did not show any significant changes. To our knowledge, this is the first method that approaches the identification and assessment of ZEN-sulfate derivates in a cereal matrix.
Warranty for a better world? The politics of environmental knowledge in bioeconomic sustainability certificates
Authors: Stokland Håkon B. , Aspøy Håkon , Krange Olve , Skogen Ketil 
Published: February 2023

AbstractSustainability certificates are increasingly used as tools for shaping bioeconomic production processes and trade. However, their specific effects are subjected to debate. A multitude of certificate schemes and standards are currently in use, defining and measuring sustainability in the bioeconomy in highly varying ways. Different representations of environmental effects, resulting from the use of different standards or scientific methods in certification, can have very real implications for how, where and to which degree bioeconomic production can be conducted and the environment will be conserved. Further, the implications for bioeconomic production practices and management embedded in the environmental knowledge employed in bioeconomic sustainability certificates will produce different winners and losers, and privilege some societal or individual concerns at the expense of others. In this way, sustainability certificates share some characteristics with other standards and policy tools that embody political contingencies, but are presented and often understood as objective and neutral. The paper argues that the politics of environmental knowledge involved in these processes warrant more awareness, scrutiny and explicit consideration from decision makers, policy developers and researchers.
Why Should We Care About the Manipulative Power of Algorithmic Transparency?
Authors: Wang Hao 
Published: February 2023

Abstract
Franke Philosophy & Technology, 35(4), 1-7, (2022) offers an interesting claim that algorithmic transparency as manipulation does not necessarily follow that it is good or bad. Different people can have good reasons to adopt different evaluative attitudes towards this manipulation. Despite agreeing with some of his observations, this short reply will examine three crucial misconceptions in his arguments. In doing so, it defends why we are morally obliged to care about the manipulative potential of algorithmic transparency. It suggests that we as society have a moral duty to incorporate the value of transparency into algorithmic systems while keeping algorithmic transparency itself sensitive to power relations.
GAG-therapie bij inflammatoire blaasaandoeningen; wat is de huidige bewijslast?
Authors: Janssen Dick A. W. 
Published: February 2023

SamenvattingOrale en intravesicale GAG-therapie wordt al meer dan 30 jaar toegepast bij diverse inflammatoire blaasaandoeningen. GAG-therapie heeft als doel de defecte mucosale blaasbarrière te herstellen om de inflammatie van de blaaswand te reduceren. Het huidige bewijsniveau voor de effectiviteit van GAG-therapie varieert voor verschillende indicaties. Helaas worden de meeste blaasontstekingen niet geëvalueerd in klinische richtlijnen. Deze review onderzoekt het huidige bewijs van GAG-therapie voor verschillende inflammatoire blaasaandoeningen zoals blaaspijnsyndroom/interstitiële cystitis (BPS/IC), ketamine-geïnduceerde cystitis, radiatiecystitis, eosinofiele cystitis en urineweginfecties.
Evolutionary Theoretician Edward D. Cope and the Extended Evolutionary Synthesis Debate
Authors: McGhee George R. 
Published: February 2023

AbstractThe Modern Synthesis (MS) gene-centered population model of evolution is currently being challenged by the Extended Evolutionary Synthesis (ESS) organism-centered developmental model of evolution. The predictions of the EES are here examined with respect to the arguments of Edward Drinker Cope (1840–1897) for an organism-centered evolutionary process in which organisms both shape and are shaped by their environments such that the activities of the organisms themselves play a role in their own evolution.
Global martingale solutions for stochastic Shigesada–Kawasaki–Teramoto population models
Authors: Braukhoff Marcel , Huber Florian , Jüngel Ansgar 
Published: February 2023

AbstractThe existence of global nonnegative martingale solutions to cross-diffusion systems of Shigesada–Kawasaki–Teramoto type with multiplicative noise is proven. The model describes the stochastic segregation dynamics of an arbitrary number of population species in a bounded domain with no-flux boundary conditions. The diffusion matrix is generally neither symmetric nor positive semidefinite, which excludes standard methods for evolution equations. Instead, the existence proof is based on the entropy structure of the model, a novel regularization of the entropy variable, higher-order moment estimates, and fractional time regularity. The regularization technique is generic and is applied to the population system with self-diffusion in any space dimension and without self-diffusion in two space dimensions.
On the backward design—an advanced concept for the design of welded structures for demanding applications
Authors: Björk T. , Ahola A. , Skriko T. , Lipiäinen K. 
Published: February 2023

AbstractConventionally, the design of welded structures is based on the properties of semi-finished products, such as rolled plates and strips. The effects of manufacturing processes on the material properties, such as cold forming and welding, are neglected or they are controlled by the limitations on manufacturing parameters. However, such conventional approaches do not obtain desired solutions for the end users in terms of performance of the end product. This is the case, particularly when using high-strength steels, in which the manufacturing processes can remarkably change the properties of semi-finished products, and the production quality must fulfill higher criteria compared to the structures made of low-strength or mild steels. Consequently, a new approach called backward design (BD) is established to obtain better properties for end-products and to develop more purposeful steels, improve quality in design and manufacturing, and minimize the lead time in the whole production chain. The BD concept is based on the needs of end-users and exploits simulations and digital twins, considering the whole production. However, the optimization of production, including all its adjacent phases, is a comprehensive multi-parametric task, and, thus, it will be always a compromised solution. Nevertheless, the BD concept provides a new way of thinking about the whole production, not only material but also the geometry of the construction and its fabrication phases. The issue is currently relevant because the steel industry will transform toward “green” steels (hydrogen-based reduction) and thus enable the creation of new tailored steels for end-products. In this paper, a general overview of this concept is presented.
Transitions Between Domains of Activity as “Domestications of the Eye” for the Learning of Mathematics with GGBot
Authors: Del Zozzo Agnese , Santi George 
Published: February 2023

AbstractWe present a theoretical study that allows us to attempt framing in an embodied perspective the effectiveness of the drawing robot GGBot in the learning of geometry. The aim of the article is to set the intertwining of activity, semiotics, perception, and knowledge at the crossover of Radford’s theory of objectification (TO) and Borba and Villareal’s notion of humans-with-media. Such a crossover is articulated in four building blocks: (1) processes of objectification and the role of semiotic means of objectification, where we state that digital artifacts such as the GGBot change the topology of the semiotic means of objectification; (2) cognition is sensuous and learning is a process of domestication of the eye, where perception is theoretically shaped by the interaction with GGBot; (3) GGBot and humans-with-media, where we outline new thinking collectives and their modes of activity; (4) domestication of the eye triggered by transitions between domains of activity. Each building block of our theoretical discussion is empirically anchored to four episodes involving primary school students’ learning geometrical figures using the GGBot. To conclude, we focus on two basic concepts of geometrical thinking that unfold in the shift between domains.