bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy among members of the Nepalese immigrant population in Canada
Authors: Thapa-Bajgain Kalpana , Bajgain Bishnu Bahadur , Dahal Rudra , Adhikari Kamala , Chowdhury Nashit , Chowdhury Mohammad ZI , Turin Tanvir C 
Published: January 2023

Background: Health literacy is an important public health concern and can be defined as ‘the degree or extent to which the individuals have the capacity to obtain, process and understand basic health information and services to make appropriate health decisions’. Research on health literacy among recent immigrants to Canada is not that extensive. Objective: The purpose of this paper was to describe health literacy status among Nepalese immigrants residing in Calgary, Alberta, Canada. Methods: In 2019, a cross-sectional study, using a self-administered questionnaire, was conducted among Nepalese immigrants in Calgary. The questionnaire comprised 38 questions including sociodemographic information, self-rated health status, having a chronic disease or not, health literacy, sources of health information and preference to gain health information. Results: We received 401 responses: 49.63% were from women, 51.37% were aged 36–55 years, 37.00% had graduate-level education, 44.96% had immigrated to Canada less than 5 years ago and 81.05% were employed full-time/part-time or self-employed. Findings revealed that 17.21% of survey participants had limited health literacy, followed by 40.15% who had marginal health literacy. The majority of the survey participants (71.82%) either always or often got health information from healthcare professionals, followed by online resources (56.61%). Conclusion: Noteworthy levels of limited health literacy and marginal health literacy were observed among the Nepalese immigrant population. Multidirectional, culturally tailored, community-led, collaborative initiatives are needed to improve health literacy among the immigrant population, to lessen health disparities and to promote better health outcomes.
The Peasant Question Under Nyerere’s Socialism
Authors: Shivji Issa G. 
Published: January 2023

This essay is a succinct overview of the manner in which the first president of Tanzania attempted to address the peasant question in the country. In the immediate aftermath of independence (1961–1966), Nyerere’s government bought into the World Bank’s recommendation of village settlement schemes and range development to pull the peasantry and the pastoralist out of the backward, traditional agriculture to modern, more productive agriculture and pastoralism spearheaded by what the WB called progressive farmers. Selected ‘progressive farmers’ would be resettled in new environment administered by hired management which would teach them modern husbandry under close supervision. Village settlement scheme was established at a great cost. By 1966 it was clear that both these projects were disastrous. With the adoption of the country’s socialist blueprint, the government adopted the policy of ‘small is beautiful’, so to speak. Peasant agriculture would be improved through extension services and collective production in Ujamaa villages. Peasants were not particularly enthusiastic about Ujamaa villages. Very few were established making the party diehards, including Nyerere, exasperated. In 1973 the President ordered that living in villages was compulsory and thus began the forced villagisation from 1971–1974 by which time it was estimated that some five million people were forcefully resettled in the so-called development villages. In hindsight, it can be surmised that this move both discredited the Ujamaa project and Nyerere could have lost his peasant base. Beginning late 1970s and early 1980s the country experienced its worst economic crisis due to a variety of internal and external reasons providing imperialism and internal proto-bourgeoisies an entry point for imposing the notorious structural adjustment programmes. The essay briefly discusses the fate and the fight of the peasant under the subsequent neo-liberal phase predicated on the so-called free market, private property regime and private investment exposing the peasant to the vagaries of capitalism and its crisis. The essay ends with outlining some elements of an alternative discourse to spearhead the peasant struggle for autonomous, sovereign development. JEL Codes: P32, Q15, Q24
WTO Agreement on Agriculture: Worsening India’s Agrarian Crisis
Authors: Dhar Biswajit 
Published: January 2023

India’s accession to the WTO in 1995 brought a new set of challenges for its agriculture. Most of the policies supporting agriculture, especially price support and input subsidies, labelled by the agreement on agriculture (AoA) as domestic support measures, were under the scanner. The price support measure that India uses, namely, the minimum support price (MSP) provided to most of the major crops now faces a problem as the methodology of calculating the extent of subsidies on account of MSP is working against India. Further, the AoA prevents India from using export subsidies since it was not using this instrument in the past. But the agreement allows the advanced countries that were using export subsidies to continue using this instrument, albeit at a lower level. Equally problematic for India is the fact that AoA rules are constraining the implementation of the National Food Security Act, which provides subsidised foodgrains to the disadvantaged sections. JEL codes: F13, Q17, Q18
Open-label trials for CGRP-targeted drugs in migraine prevention: A narrative review
Authors: Raffaelli Bianca , De Icco Roberto , Corrado Michele , Terhart Maria , Ailani Jessica 
Published: January 2023

Background Calcitonin gene-related peptide-targeted drugs have proven safe and effective for migraine prevention in large randomized-controlled, double-blind trials with an average duration of six months. Open-label studies may provide additional information on the long-term safety and efficacy of these substances. Methods We searched PubMed for open-label trials with calcitonin gene-related peptide(-receptor) monoclonal antibodies and calcitonin gene-related peptide-receptor antagonists. We summarized and critically analyzed the literature in a narrative way. Results Overall, 13 open-label trials were included in this review (n = 4 for erenumab, n = 4 for galcanezumab, n = 3 for fremanezumab, n = 1 for eptinezumab, n = 1 for atogepant). Open-label trial duration ranged between 12 and 264 weeks. No safety concerns emerged, and the adverse events profile was similar to the double-blind study phase. Discontinuation rates were generally low with >75% of patients remaining in the trials after one year. Efficacy data showed a sustained reduction of migraine frequency throughout the trials, along with a lasting improvement in quality of life. Conclusions The open-label study program for calcitonin gene-related peptide-targeted migraine preventives confirms the favorable safety and efficacy profile of these drugs over time. Treatment adherence appears higher than with previous unspecific migraine preventives. Real-world data and post-marketing surveillance studies may corroborate and complement open-label results.
Disseminated Herpes Simplex Infection in a Neonate
Authors: Basu Maitreyi , Ghosh Sibarjun , Dutta Abhijit , Saha Sudip 
Published: January 2023

Herpes simplex virus (HSV) infection in a newborn is commonly due to HSV 2 and less commonly due to HSV 1.1,2 Mixed HSV 1 & 2 infection in newborn is rarely reported.3 Neonatal HSV infection can present as- a) Localized skin, eye and mouth (SEM) affection; b) Central nervous system (CNS) disease or c)Disseminated disease.1,4,5 We report an unusual case of HSV infection in a neonate due both HSV 1 & HSV 2. It led to initial manifestation just like septicemia and ultimately prolonged cholestasis that responded to acyclovir therapy.
Early Diagnosis of Pancreatic Cancer: Clinical Premonitions, Timely Precursor Detection and Increased Curative-Intent Surgery
Authors: Søreide Kjetil , Ismail Warsan , Roalsø Marcus , Ghotbi Jacob , Zaharia Claudia 
Published: January 2023

Background The overall poor prognosis in pancreatic cancer is related to late clinical detection. Early diagnosis remains a considerable challenge in pancreatic cancer. Unfortunately, the onset of clinical symptoms in patients usually indicate advanced disease or presence of metastasis. Analysis and Results Currently, there are no designated diagnostic or screening tests for pancreatic cancer in clinical use. Thus, identifying risk groups, preclinical risk factors or surveillance strategies to facilitate early detection is a target for ongoing research. Hereditary genetic syndromes are a obvious, but small group at risk, and warrants close surveillance as suggested by society guidelines. Screening for pancreatic cancer in asymptomatic individuals is currently associated with the risk of false positive tests and, thus, risk of harms that outweigh benefits. The promise of cancer biomarkers and use of ‘omics’ technology (genomic, transcriptomics, metabolomics etc.) has yet to see a clinical breakthrough. Several proposed biomarker studies for early cancer detection lack external validation or, when externally validated, have shown considerably lower accuracy than in the original data. Biopsies or tissues are often taken at the time of diagnosis in research studies, hence invalidating the value of a time-dependent lag of the biomarker to detect a pre-clinical, asymptomatic yet operable cancer. New technologies will be essential for early diagnosis, with emerging data from image-based radiomics approaches, artificial intelligence and machine learning suggesting avenues for improved detection. Conclusions Early detection may come from analytics of various body fluids (eg ‘liquid biopsies’ from blood or urine). In this review we present some the technological platforms that are explored for their ability to detect pancreatic cancer, some of which may eventually change the prospects and outcomes of patients with pancreatic cancer.
Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags
Authors: Closset Mélanie , Onorati Sabrina , Colsoul Marie-Lise , Goderniaux Nicolas , Bihin Benoît , Jamart Jacques , Soumoy Laura , Hecq Jean-Daniel , Odou Pascal , Galanti Laurence 
Published: January 2023

Background Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized Intravenous Admixture Service. Aim of the study To evaluate the long-term stability of 5-fluorouracil at banded doses (700 mg and 800 mg) in polyolefin bags. Materials and methods Ten polyolefin bags were prepared under aseptic conditions and stored at 23 ± 2°C for 24 days. Five of them were composed of 14 mL 5-fluorocuracil (700 g) in 100 mL 0.9% sodium chloride solution and the five other of 16 mL 5-fluorouracil (800 mg) in 100 mL 0.9% sodium chloride solution. At defined times, physical stability parameters were assessed: optical densities, pH measurements, visual and microscopical inspections. Solutions concentrations were measured using high-performance liquid chromatography coupled with a photodiode array detector. Results No change was observed on pH and optical density measurements during the study period. Visual and microscopical inspections remained free of colour change, precipitate, microagregate or crystal. The concentrations of 5-Fluorouracil in 800 mg bags remained stable for 24 days while the concentration in 700 mg bags showed a stability of at least 17 days. Conclusion Five-fluorouracil at banded doses of 700 and 800 mg in polyolefin bags is physicochemically stable for at least 17 days at 23 ± 2°C. These results support the possibility of in advance centralised preparation.
Risk assessment of personnel exposure in a central cytotoxic preparation unit using the FMECA method
Authors: Bhirich Nihal , Chefchaouni Ali Cherif , Medkouri Safaa El , Shytry Oumaima , Belahcen Mohammed Jaouad , Rahali Younes 
Published: January 2023

Introduction Personnel involved in the preparation of cytotoxics are exposed to them and the resulting risks. To protect themselves, many means of protection are currently implemented. Nevertheless, the exposure of these manipulators remains a possibility to be considered. Materials and methods The study was conducted during the period (October–November 2022) in the pharmacy of the National Institute of Oncology (INO), a hospital structure specializing in cancer care. The Failure Mode, Effects and Criticality Analysis method was used to assess the risks of exposure of personnel in a central cytotoxic preparation unit and then calculate the criticality index (CI  =  severity  ×  frequency  ×  detectability). The risks were classified into toxic, traumatic, chemical, and environmental risks. We have cited 12 failure modes of which nine are minor and three are major. The three major modes cited are essentially related to the particulate environment, direct contact and daily passive inhalation of handling. Conclusion Our study shows that in our institution, the analysis of the risk of exposure of personnel to cytotoxics remains important, hence the interest of automaton in charge of preparations and which will gradually take charge of all the preparations. The existing procedures and the pharmacotechnical equipment used also contribute to protection and risk reduction.
Persisting Cancer in Black Salve Treated Skin Lesions: Results of a Large 5 Year Retrospective Analysis of Australian Histopathology Specimens
Authors: Croaker Andrew , Liu Lei , Myers Stephen P. 
Published: January 2023

Background: To date there has been minimal research on the use of black salve escharotics. Whether cancer persistence is a frequent finding in treatment areas, the types of lesion being treated by patients, whether rural patients are more likely to use black salve and whether current government prevention initiatives are succeeding are all issues needing investigation. Methods: This study was a large national retrospective black salve pathology case series from 2015 to 2019. Five private pathology companies with 1471 collection centers located in 5 of the 8 Australian states and Territories provided de-identified skin pathology report information where black salve treatment had been documented in the pathology request. Results: Over the 5-year period 409 patients had treated 475 lesions with black salve. Benign lesions were present at the treatment site in 18% of cases; persisting cancer was found in 34.2% of the remaining black salve treated areas. The majority of treatment areas were located on the head and neck. Black salve caused necrosis of normal tissue when treating benign lesions, refuting claims of cancer specificity. Likelihood of black salve use increased with rurality based on Modified Monash (MM) scores. Black salve use, despite regulatory efforts, appears to be increasing with specimen numbers more than doubling from 2015 to 2019. Conclusions: Patients undergoing histopathological assessment of black salve treatment areas have high rates of cancer persistence. Patients are applying black salve to benign lesions and lesions in cosmetically sensitive areas. Rural patients have higher proportional rates of black salve use. The increasing incidence of black salve pathology specimens suggests current Australian black salve public health initiatives are failing.
Outcome following nivolumab treatment in patients with advanced non-small cell lung cancer and comorbid interstitial lung disease in a real-world setting
Authors: Assié Jean-Baptiste , Chouaïd Christos , Nunes Hilario , Reynaud Dorothée , Gaudin Anne-Françoise , Grumberg Valentine , Jolivel Ronan , Jouaneton Baptiste , Cotté François-Emery , Duchemann Boris 
Published: January 2023

Background: Up to 10% of patients with advanced non-small cell lung cancer (aNSCLC) have pre-existing interstitial lung disease (ILD). These patients are usually excluded from immunotherapy clinical trials. Consequently, knowledge on outcomes following nivolumab treatment in these patients remains limited. The primary objective of this study was to evaluate survival outcome following nivolumab treatment in ILD patients with pre-treated aNSCLC in the real-world setting. Patients and methods: The study included all patients with aNSCLC recorded in the French hospital database, starting nivolumab in 2015–2016. Patients were stratified by pre-existing ILD and three subgroups were studied [auto-immune or granulomatous (AI/G) ILD, other known causes ILD and idiopathic ILD]. Time to discontinuation of nivolumab treatment [time to treatment duration (TTD)] and overall survival (OS) were estimated using Kaplan–Meier survival analysis. Results: Of 10,452 aNSCLC patients initiating nivolumab, 148 (1.4%) had pre-existing ILD. Mean age at nivolumab initiation was 64.6 ± 9.4 years in ILD and 63.8 ± 9.6 years in non-ILD. Compared to non-ILD, patients in the ILD group were more frequently men ( p < 0.05) and had more comorbidities ( p < 0.001). There was no significant difference between ILD and non-ILD groups for median TTD (2.5 versus 2.8 months; p = 0.6) or median OS (9.6 versus 11.9 months; p = 0.1). Median OS in AI/G ILD ( n = 14), other known causes ILD ( n = 75), and idiopathic ILD ( n = 59) were 8.6, 10.7, and 9.6 months, respectively. Conclusion: In this large cohort of aNSCLC patients with ILD, outcomes are similar to those obtained in the non-ILD population. Immunotherapy could be beneficial for these patients.
Newly discovered roles of triosephosphate isomerase including functions within the nucleus
Authors: Myers Tracey D. , Palladino Michael J. 
Published: January 2023

AbstractTriosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolism of DHAP and a net yield of ATP from anaerobic glucose metabolism. Loss of TPI function results in the recessive disease TPI Deficiency (TPI Df). Recently, numerous lines of evidence suggest the TPI protein has other functions beyond glycolysis, a phenomenon known as moonlighting or gene sharing. Here we review the numerous functions ascribed to TPI, including recent findings of a nuclear role of TPI implicated in cancer pathogenesis and chemotherapy resistance.
PP-DDP: a privacy-preserving outsourcing framework for solving the double digest problem
Authors: Suo Jingwen , Gu Lize , Yan Xingyu , Yang Sijia , Hu Xiaoya , Wang Licheng 
Published: January 2023

AbstractBackgroundAs one of the fundamental problems in bioinformatics, the double digest problem (DDP) focuses on reordering genetic fragments in a proper sequence. Although many algorithms for dealing with the DDP problem were proposed during the past decades, it is believed that solving DDP is still very time-consuming work due to the strongly NP-completeness of DDP. However, none of these algorithms consider the privacy issue of the DDP data that contains critical business interests and is collected with days or even months of gel-electrophoresis experiments. Thus, the DDP data owners are reluctant to deploy the task of solving DDP over cloud.ResultsOur main motivation in this paper is to design a secure outsourcing computation framework for solving the DDP problem. We at first propose a privacy-preserving outsourcing framework for handling the DDP problem by using a cloud server; Then, to enable the cloud server to solve the DDP instances over ciphertexts, an order-preserving homomorphic index scheme (OPHI) is tailored from an order-preserving encryption scheme published at CCS 2012; And finally, our previous work on solving DDP problem, a quantum inspired genetic algorithm (QIGA), is merged into our outsourcing framework, with the supporting of the proposed OPHI scheme. Moreover, after the execution of QIGA at the cloud server side, the optimal solution, i.e. two mapping sequences, would be transferredpubliclyto the data owner. Security analysis shows that from these sequences, none can learn any information about the original DDP data. Performance analysis shows that the communication cost and the computational workload for both the client side and the server side are reasonable. In particular, our experiments show that PP-DDP can find optional solutions with a high success rate towards typical test DDP instances and random DDP instances, and PP-DDP takes less running time than DDmap, SK05 and GM12, while keeping the privacy of the original DDP data.ConclusionThe proposed outsourcing framework, PP-DDP, is secure and effective for solving the DDP problem.
Systematic and benchmarking studies of pipelines for mammal WGBS data in the novel NGS platform
Authors: Lin Qun-ting , Yang Wei , Zhang Xin , Li Qi-gang , Liu Yong-feng , Yan Qin , Sun Lei 
Published: January 2023

Abstract
Background
Whole genome bisulfite sequencing (WGBS), possesses the aptitude to dissect methylation status at the nucleotide-level resolution of 5-methylcytosine (5-mC) on a genome-wide scale. It is a powerful technique for epigenome in various cell types, and tissues. As a recently established next-generation sequencing (NGS) platform, GenoLab M is a promising alternative platform. However, its comprehensive evaluation for WGBS has not been reported. We sequenced two bisulfite-converted mammal DNA in this research using our GenoLab M and NovaSeq 6000, respectively. Then, we systematically compared those data via four widely used WGBS tools (BSMAP, Bismark, BatMeth2, BS-Seeker2) and a new bisulfite-seq tool (BSBolt). We interrogated their computational time, genome depth and coverage, and evaluated their percentage of methylated Cs.

Result
Here, benchmarking a combination of pre- and post-processing methods, we found that trimming improved the performance of mapping efficiency in eight datasets. The data from two platforms uncovered ~ 80% of CpG sites genome-wide in the human cell line. Those data sequenced by GenoLab M achieved a far lower proportion of duplicates (~ 5.5%). Among pipelines, BSMAP provided an intriguing representation of 5-mC distribution at CpG sites with 5-mC levels > ~ 78% in datasets from human cell lines, especially in the GenoLab M. BSMAP performed more advantages in running time, uniquely mapped reads percentages, genomic coverage, and quantitative accuracy. Finally, compared with the previous methylation pattern of human cell line and mouse tissue, we confirmed that the data from GenoLab M performed similar consistency and accuracy in methylation levels of CpG sites with that from NovaSeq 6000.

Conclusion
Together we confirmed that GenoLab M was a qualified NGS platform for WGBS with high performance. Our results showed that BSMAP was the suitable pipeline that allowed for WGBS studies on the GenoLab M platform.