bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: The non-pharmacological interventions of people with psoriasis: a scoping review
Authors: Zhang Zhang Xiujie , Lin Jing-rong , Ou Min-xing , Feng Li , Gong Fu-qing 
Published: December 2022

Abstract
Introduction

The ultimate aim of health care is to eradicate a disease and return the person’s life to normal. But until the day comes when this has been achieved there will be a need to support and assist many people with psoriasis in non-pharmacological interventions. These ‘adjuvant’ approaches receive too little attention while dermatologists and researchers strive for better pharmacological therapy.

Methods

This scoping review identifies and catalogues non-pharmacological interventions in people with psoriasis. EMBASE, PubMed, CINAHL, PsycINFO and Scopus were searched from inception to June 2022. Regardless of the type of study, the research was included for non-pharmacological interventions in people with psoriasis. Following themes were extracted from the included articles. Two reviewers independently screened and analyzed them.

Results

From 1322 initial records, 71 studies were identified and analyzed. The non-pharmacological interventions for people with psoriasis include two levels of organizational and individual intervention. The organizational non-pharmacological interventions included the following: nationwide health care model (PsPSP, ProvenCare®, PsoHealth German, PsoNet, IMPROVE model and PsoWell clinic), innovative teledermatology models (mHealth APP, eTIPs study and therapist-Guided internet-based cognitive and behavioral treatments) and multidisciplinary intervention. The individual non-pharmacological interventions included educational interventions (therapeutic patient education, psycho-educational intervention and self-management education), psychosocial interventions (cognitive and behavioral treatments, self-help and peer to peer support program) and others (happify and motivational interviewing-based training).

Conclusions

Based on the previous literatures, a protocol of nationwide health care model was constructed for people with psoriasis. It not only provides a direction for building a new psoriatic health care model, but also a basis for summarizing the non-pharmacological interventions in people suffered from psoriasis to help them adapt to a variety of changes in skin disorder.
Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin
Authors: Shimazu Yutaka , Kanda Junya , Kosugi Satoru , Ito Tomoki , Kaneko Hitomi , Imada Kazunori , Shimura Yuji , Fuchida Shin-ichi , Fukushima Kentaro , Tanaka Hirokazu , Yoshihara Satoshi , Ohta Kensuke , Uoshima Nobuhiko , Yagi Hideo , Shibayama Hirohiko , Yamamura Ryosuke , Tanaka Yasuhiro , Uchiyama Hitoji , Onda Yoshiyuki , Adachi Yoko , Hanamoto Hitoshi , Takahashi Ryoichi , Matsuda Mitsuhiro , Miyoshi Takashi , Takakuwa Teruhito , Hino Masayuki , Hosen Naoki , Nomura Shosaku , Shimazaki Chihiro , Matsumura Itaru , Takaori-Kondo Akifumi , Kuroda Junya 
Published: December 2022

Abstract
Novel therapeutic drugs have dramatically improved the overall survival of patients with multiple myeloma. We sought to identify the characteristics of patients likely to exhibit a durable response to one such drug, elotuzumab, by analyzing a real-world database in Japan. We analyzed 179 patients who underwent 201 elotuzumab treatments. The median time to next treatment (TTNT) with the 95% confidence interval was 6.29 months (5.18–9.20) in this cohort. Univariate analysis showed that patients with any of the following had longer TTNT: no high risk cytogenic abnormalities, more white blood cells, more lymphocytes, non-deviated κ/λ ratio, lower β2 microglobulin levels (B2MG), fewer prior drug regimens, no prior daratumumab use and better response after elotuzumab treatment. A multivariate analysis showed that TTNT was longer in patients with more lymphocytes (≥ 1400/µL), non-deviated κ/λ ratio (0.1–10), lower B2MG (< 5.5mg/L) and no prior daratumumab use. We proposed a simple scoring system to predict the durability of the elotuzumab treatment effect by classifying the patients into three categories based on their lymphocyte counts (0 points for ≥ 1400/µL and 1 point for < 1400/µL) and κ/λ ratio (0 points for 0.1–10 and 1 point for < 0.1 or ≥ 10) or B2MG (0 points for < 5.5mg/L and 1 point for ≥ 5.5mg/L). The patients with a score of 0 showed significantly longer TTNT (p < 0.001) and better survival (p < 0.001) compared to those with a score of 1 or 2. Prospective cohort studies of elotuzumab treatment may be needed to validate the usefulness of our new scoring system.
Study and comparison of prognostic characteristics of lung adenocarcinoma based on tumor microenvironment gene set
Authors: Yuan Jianxu , Jiang Qing , Wang Jiawu , Hua Zhengzhao , Yu Shengjie 
Published: December 2022

Abstract
Background: TME (Tumor microenvironment) plays a key role in the occurrence and development of lung cancer. Further research on TME will provide more comprehensive insights into relevant prognostic biomarkers and potential therapeutic targets. The purpose of this study is to develop a better prognosis model to predict the OS (overall survival) time of LUAD patients by identifying the TME component in lung cancer (especially lung adenocarcinoma) and comparing it with previous similar research results.
Methods: The original LUAD related data was from TCGA (the Cancer Genome Atlas). The DEGs (differentially expressed genes) related to TME in tumor tissues and normal tissues were calculated respectively. Then, NMF (nonnegative matrix factorization) clustering was applied to identify different subtypes. Univariate Cox regression analysis and lasso regression analysis were performed to screen genes with prognostic significance to construct the prognostic characteristics. Finally, ROC (receiver operating characteristic) curve and DCA (decision curve analysis) were used to verify the model both internally and externally.
Results: Finally, we constructed a LUAD prognosis model containing five TME related genes (including C1QTNF6, PLEK2, FURIN, TM6SF1 and IGF2BP1). In our model, the survival time of high-risk group was indeed shorter. The prediction accuracy of the model was further verified by an independent cohort (GSE13213) in GEO (the Gene Expression Omnibus). In addition, we also integrated relevant clinical factors and drew a prognosis nomograph. The results showed that the patients in the high-risk group had less immune cell infiltration, more fibroblasts in the tissues, and poorer prognosis.
A prospective cohort study of clinical characteristics and outcome of Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer
Authors: Fan Yu , Zhong Xiaorong , Wang Yu , Wang Zhu , Wang Yanping , Zheng Hong 
Published: December 2022

Abstract
Background
There has been a debate about whether the estrogen receptor (ER) -negative/progesterone receptor (PR) -positive breast cancer exists or is an artefact. Further, there have been conflicting results as to whether PR is a molecular marker for the benefit of adjuvant endocrine therapy (ET).
Methods
Early breast cancer patients of West China Hospital were divided into the ER-/PR+ group, ER+ group and ER-/PR- group. The Chi-square test was employed to analyze the differences in clinical and pathological features among the three groups. Multivariate Cox regression and Kaplan-Meier survival analysis were employed to compare the survival difference between all patients of the three groups, between the patients who had received ET of the three groups, and between patients who had or had not received ET in the ER-/PR+ group. Finally, we analyzed which subgroups of ER-/PR+ patients would benefit from ET.
Results
From 2008 to 2020, we enrolled 10494 early breast cancer patients with definite ER and PR status. 445, 7129, and 2920 patients were in the ER-/PR+ group, ER+ group and ER-/PR- group, respectively. ER-/PR+ group displayed unfavourable clinical and aggressive pathological characteristics than the ER+ group. The breast cancer-specific survival (BCSS), local recurrence-free survival (LRFS) and distant disease-free survival (DDFS) of the ER-/PR+ group were worse than those of the ER+ group. After ET, the ER-/PR+ group still had a worse BCSS, LRFS and DDFS than those in the ER+ group. Patients who received ET in the ER-/PR+ group showed significantly better LRFS and BCSS than patients who did not, but there was no difference in DDFS. Subgroup analysis suggested ER-/PR+ patients with PR≥10% instead of PR<10% could benefit from ET.
Conclusion
The ER-/PR+ group has unfavourable clinic-pathological features and a worse prognosis than the ER+ group. ET still reduces endpoint events of LRFS and BCSS but could not reduce DDFS endpoint events. Further, subgroup analysis suggests ER-/PR+ patients could benefit from ET when PR expression is≥10%.
Large-scale Pacific-sourced intrusion into the glacial South Atlantic
Authors: Hallmaier Moritz , Rückert Eva , Link Jasmin , Lütkes Laura , Frank Norbert 
Published: December 2022

Abstract
The deep Southern Ocean (SO) circulation plays a key role in the storage and release of CO2 in Earth’s climate system. Uptake and release of CO2 strongly depend on the redistribution of well and poorly ventilated water masses. Here, we present new neodymium isotope data (εNd) from three sediment cores from the Atlantic sector of the SO to assess the distribution of water masses during the past 150 ka.
ODP 1094 (2807 m) reveals a tremendous Holocene εNd-variability (-0.25 to -6.07), which most likely reflects local influences. PS 1768-8 (3299 m) and ODP 1093 (3624 m), show far more unradiogenic interglacial εNd-signatures, which are similar to the present-day Antarctic Bottom Water (AABW) (εNd~-8). During peak glacial periods, radiogenic εNd-values of ~-2.5 to -3.5 are recorded. This confirms a predominance of glacial Pacific-sourced deep water at depths of 3.3-3.6 km in the South Atlantic, with proportions close to 100% and lacking AABW. We advocate for the presence of Pacific Deep Water even during interglacials and further hypothesize that a possible intrusion due to a warming climate could accelerate climate warming. The persistent occurrence of such a highly radiogenic water mass substantially changes the view regarding the selection of the Southern Hemisphere εNd-endmember for the Atlantic Ocean and reinforces the major importance of carbon storage in the Glacial SO.
All-optical control of high-purity trions in nanoscale waveguide
Authors: Lee Hyeongwoo , Koo Yeonjeong , Kumar Shailabh , Jeong Yunjo , Heo Dong Gwon , Choi Soo Ho , Joo Huitae , Kang Mingu , Siddique Radwanul , Kim Ki Kang , Lee Hong Seok , An Sangmin , Choo Hyuck , Park Kyoung-Duck 
Published: December 2022

Abstract
The generation of high-purity localized trions, dynamic exciton–trion interconversion, and their spatial modulation in 2D semiconductors are building blocks for the realization of trion-based optoelectronic devices. Here, we present a method for the alloptical control of the exciton-to-trion conversion process and its spatial distributions in a MoS2 monolayer. We induce a nanoscale strain gradient in a 2D crystal transferred on a metal–insulator–metal (MIM) waveguide and exploit propagating surface plasmon polaritons (SPPs) to localize hot electrons. These significantly increase the electrons and efficiently funnel excitons in the MIM waveguide, facilitating complete exciton-to-trion conversion even at ambient conditions. Additionally, we modulate the SPP mode using adaptive wavefront shaping, enabling all-optical control of the exciton-to-trion conversion rate and trion distribution in a reversible manner. Our work provides a platform for harnessing excitonic quasiparticles efficiently in the form of trions at ambient conditions, enabling high-efficiency photoconversion.
Decolorization of Stevia rebaudiana (Bert.) leaf extracts with activated charcoal and qualitative analysis of stevioside using chromatographic methods
Authors: Bhuiyan Mohammad Nazrul Islam , Shamima Kazi Asma Ahmed , Nahid Meher , Afrin Sadia , Hoque Mohammad Amirul , Haque Mohammad Majedul , Sarker Md. Khabir Uddin , Miah Md. Abdus Satter , Shaikh Md. Aftab Ali 
Published: December 2022

Abstract
Background
The Stevia rebaudiana (Bert.) leaves are natural low-calorie sweeteners that are used in a wide range of products, including foods, drinks, medicines, cosmetics, and more. The current study aims to obtain high-purity stevioside by decolorizing the Stevia leaf extracts with activated charcoal, then purifying them with 70% ethanol, and concentrating them in a rotary evaporator, respectively.
Results
The yield was then calculated by weighing the crystallized sample following freeze-drying. The average yield is 8.13%. According to High-Performance Liquid Chromatography (HPLC), the purity is 98.12%. The obtained stevioside was compared to standard stevioside and confirmed using Ultra Violet-Visible Spectroscopy (UV-Vis) and Fourier Transform Infrared (FT-IR) spectroscopy. The purified sample showed a wavelength region of 4000–650 cm-1 in FT-IR and UV-Vis spectrum was found at a wavelength of 206.49 nm. An accuracy and precision test was done with a crystal sample, which gave a similar spectrum to the standard stevioside at the same retention time in HPLC. The pH effect on the decolorization of Stevia leaf extracts with activated charcoal was 5.5–8.0.
Conclusion
In contrast to other commercially available methods, the aforementioned method can be used to purify pure stevioside from Stevialeaf extracts rapidly, simply, and, inexpensively.
Mechanical Vibration Promotes Osteogenic Differentiation of Human Periodontal Ligament Cells and their Inhibitory Regulation of Osteoclastogenesis
Authors: Cai guanhui , Ren chaochao , wang ting , Wang hua , liu dawei 
Published: December 2022

Abstract
Background: Periodontal ligament (PDL) is a dense fibrous connective tissue connecting tooth to its alveolar socket. As the most abundant cells in the PDL, PDL fibroblasts possess osteoblastic phenotypes and are mechanoresponsive to various mechanical stimuli including vibration. Recent studies show that low magnitude (0.2-0.5 g) high frequency (30-120 Hz) vibrations (LMHFV) could increase the mass and density of alveolar bone as well as restrain the atrophy of alveolar bone after tooth extraction. However, the cellular and molecular mechanisms of these anabolic actions of mechanical vibration are largely unknown. To study the effects of mechanical vibration on the osteogenic differentiation of human periodontal ligament cells (hPDLCs) and its regulation on osteoclast formation, hPDLCs were subjected to sinusoidal LMHFV (0.3 g) at various frequencies (30, 60, 90 Hz).
Methods and Results: Our results show that LMHFV enhanced osteogenic differentiation of hPDLCs most significantly at 60 Hz. Induction with the conditioned medium (CM) from the vibrated hPDLCs significantly inhibited osteoclastic formation. Mechanistically, LMHFV significantly induced potentiation of Wnt/β-catenin signaling, in parallel with the up-regulated expressions of osteogenic marker genes RUNX2, OPN and BSP which were enhanced by LiCl. LiCl treatment also enhanced the LMHFV-induced up-regulation of osteoprotegerin (OPG)/nuclear factor-κ b ligand (RANKL) ratio.
Conclusions: LMHFV (0.3 g, 60 Hz) could maximally promote osteogenic differentiation of hPDLCs via potentiation of Wnt/β-catenin signaling and regulate its downstream OPG/RANKL axis towards inhibiting osteoclastogenesis.
Synergistic Governance for Regional Environment under Uncertainty: A Model of Cooperative Game with Intuitionistic Fuzzy Coalitions
Authors: Guo Shuai , Luo Donglin 
Published: December 2022

Abstract
Synergistic governance is an important way to realize the modernization of regional environmental governance capacity. This paper uses the intuitionistic fuzzy coalition cooperative game method with nonlinear programming to construct the optimal coalition structure and cooperative profit distribution model of regional environmental governance, and verifies its rationality and validity with the industrial statistics of Shaanxi, Henan and Shanxi provinces in China. The results shows: First, the total profits of the three provinces are maximized, and the profits allocated to each province are greater than those of working alone after transferring cooperative profits; Second, the method makes the distribution loss rates is 2.1453E-07, -6.6042E-08 and -1.9103E-07 respectively, whose the loss deviations are negligible; Third, three policy recommendations are offered: Integrating coalition structures to achieve structural synergy; Promoting transparent sharing of information on environmental cooperation to achieve data synergy; Innovating profit distribution mechanism to realize profit sharing.
Inactivated poliovirus vaccine induced Guillain–Barré syndrome: A Case Report
Authors: Bereda Gudisa 
Published: December 2022

Abstract
Guillain-Barré syndrome is a type of immune-mediated acute polyradiculoneuritis that is typically preceded by an unspecified infection. A 6-year-old black male preliminary school student who admitted to the pediatric ward with generalized body weakness comprising both lower and upper extremities (unable to move legs and hands as a usual motor movement), not walking alone without caregiver assistance, being unable to swallow food, blurred vision, tingling in the feet and hands, an irregular heartbeat, and severe muscular pain. The patient had quadriparesis, or muscle weakness, in all four limbs (both legs and arms). Motor examination revealed decreased muscle strength in all limbs, with a Medical Research Council score of 2/5 in the right arm of the upper extremities and 1/5 in the right leg of the lower extremities, and 1/5 in the left leg of the lower extremities and 2/5 in the left arm of the upper extremities. According to the clinical signs of Guillain-Barré syndrome, he received 400 mg/kg of intravenous immunoglobulin every day for five days.
Correction of hypertriglyceridemia by intestinal microbiota remodeling alleviates NASH and atherosclerosis in severe combined hyperlipidemia disease
Authors: Miao Guolin , Guo Jiabao , Lai Pingping , Chen Jingxuan , Zhou Zihao , Zhang Wenxi , Xu Yitong , Zhang Lianxin , Han Yufei , Chen Gonglie , Chen Jinxuan , Tao Yijun , Zhang Ling , Huang Wei , Wang Yuhui , Xian Xunde 
Published: December 2022

Abstract
Background
Combined hyperlipidemia (CHL), characterized by elevated cholesterol and triglyceride levels in circulation, is a common risk factor of cardiovascular disease (CVD) accompanied by obesity, insulin resistance and fatty liver. Emerging lines of evidence demonstrate that intestinal microbiota plays a central role in the development of metabolic disease and the application of antibiotics can influence microbial homeostasis in gut, suggesting that modulation of microbiota profiling by antibiotics could improve metabolic abnormalities. However, the beneficial consequence of CHL yielded by antibiotic-mediated remodeling of intestinal microbiota has not been investigated yet and whether intestinal microbiota can be a potential therapeutic target for CHL is still unknown so far.
Results
Intermittent antibiotic treatment and transfer of gut microbiota through cohousing approach could effectively change gut microbial composition and functions but didn't affect microbiota abundance in low density lipoprotein receptor deficient (LDLR−/−) hamsters fed an HFHC diet compared to placebo-treated control group. Modulating gut microbiota significantly reduced body weight gain, lowered plasma triglyceride levels without affecting cholesterol concentration, restrained adipocyte hypertrophy and brown adipocyte whitening, eventually alleviating obesity, non-alcoholic steatohepatitis (NASH) and atherosclerosis. Further omic analysis of intestinal microbiota showed that along with sequentially increased bacterial richness, Lactobacillus, Clostridia_UCG-014, Bifidobacterium and Eubacterium_coprostanoligenes_group were key four species that droved severe CHL-associated NASH progression. Additionally, we observed that Fusobacterium, Blautia, Parasutterella, and Methanosphaera genera were enriched in antibiotic treated LDLR−/− hamsters with mitigating aberrant intestinal absorption, NASH and atherosclerotic lesions.
Conclusion
Remodeling gut microbiota by antibiotics and transfer gut microbiota via cohousing approach effectively corrects hypertriglyceridemia in HFHC diet-fed LDLR−/− hamsters, which is sufficient to improve obesity, non-alcoholic steatohepatitis (NASH) and atherosclerosis caused by refractory CHL, further confirming that hypertriglyceridemia is the important risk factor for CVD and then suggesting that intestinal microbiota exert a therapeutic potential in CHL disease.
Enhanced forward error correction scheme in ACELP based codec for voice over IP network services
Authors: Gueham Tarek , Merazka Fatiha 
Published: December 2022

Abstract
Forward Error Correction (FEC) is a packet loss concealment (PLC) mechanism used to recover lost packets via the transmission of a set of redundant packets along with the original ones. Given its performance in improving the end-to-end error recovery capability of lossy networks as well as maximizing the end-to-end quality of service (QoS), FEC is usually considered to be an interesting choice for real-time applications like voice over Internet protocol (VoIP). Note that this mechanism has a low efficiency against consecutive packet losses, which heavily affects the perceptual speech quality in a VoIP environment and could even produce a total desynchronization between the coder and the decoder. The objective of this paper is to introduce a new FEC scheme that can address the aforementioned issue. We use also a Time Scale Modification (TSM) procedure that enhance the performance of our proposed FEC scheme in order to further improve the performance of our scheme under severe network conditions. Subjective and objective evaluation metrics are used to evaluate the efficiency of the proposed method. Results show that the new FEC method achieves a Perceptual evaluation of speech quality (PESQ) value exceeding 3.5 at a 10% frame erasure rate with a noticeable enhancement in voice perception.
Construction of a risk prediction model for ureteral stricture after ureteroscopic holmium laser lithotripsy
Authors: Li Ping , Wang Kangning , Luo Lin , Xie Qingzhi , Wu Yunchou , Liao Qiuling 
Published: December 2022

Abstract
Objective To analyze the influencing factors of ureteral stenosis after ureteroscopic holmium laser lithotripsy.
Methods The clinical data of 427 patients treated with ureteroscopic holmium laser lithotripsy were selected, and the patients were divided into two groups according to whether the patients had ureteral stenosis after operation. Univariate and multivariate Logistic regression were used to analyze the independent risk factors for postoperative ureteral stenosis, and R software and regression coefficients were used to construct a predictive model.
Results After a one-year follow-up of 427 patients, 28 patients (6.56%) developed ureteral stenosis; univariate analysis showed that the occurrence of ureteral stenosis after subureteral holmium laser lithotripsy was related to stone diameter, stone incarceration,degree of hydronephrosis, holmium laser injury of mucosa, and operation time (P<0.05); further Logistic regression analysis showed that long stone diameter, stone incarceration, and moderate to severe hydronephrosis were independent risk factors for ureteral stricture after ureteroscopic holmium laser lithotripsy (P<0.05); the H-L deviation degree and the area under the ROC curve were used to test, and the results showed that the model had high accuracy and discrimination.
Conclusion Stone diameter, stone incarceration, and degree of hydronephrosis were independent risk factors that affect the occurrence of ureteral stricture after ureteroscopic holmium laser lithotripsy. The nomogram model established by this result has high accuracy and discrimination. It can effectively identify high-risk groups to prevent ureteral stenosis in time and minimize the risk of ureteral stenosis after surgery.