bluuebunny/crossref_metadata_2025_split huggingface dataset:
Münsteraner Standard: modifizierte PAUL®-Implantation bei Zustand nach PreserFlo® MicroShunt-Implantation. Videobeitrag
Authors: Brücher Viktoria C. , Zimmermann Julian A. , Storp Jens J. , Eter Nicole 
Published: September 2023

Zusammenfassung
Operationsziel
Ziel dieser Operationstechnik ist die modifizierte Anlage eines PAUL®-Implantates (Fa. Advanced Ophthalmic Innovations, Singapur) in Augen nach PreserFlo® MicroShunt(Fa. Santen, Osaka, Japan)-Implantatversagen zur bestmöglichen Augeninnendruckeinstellung.

Indikationen
Die Operationsindikation bezieht sich auf komplexere Glaukome, die bereits erfolglos mittels PreserFlo® MicroShunt operiert wurden.

Operationstechnik
Die Besonderheiten des Münsteraner Standards sind die Wahl des Operationsgebietes und der Verzicht auf eine weitere Tunnelneuanlage. Die Patienten erhalten eine PAUL®-Implantation im selben Quadranten der zuvor erfolgten PreserFlo® MicroShunt-Implantation (superior-temporal). Nach Präparation der Bindehaut, Priming des PAUL®-Implantates mittels Prolene‑6.0‑Faden und Fixierung der Platte erfolgt die Explantation des PreserFlo® MicroShunt. Um die Implantation des PAUL®-Schlauchs durch den alten 25-Gauge-Tunnel zu vollziehen, wird dieser mittels Irisspatel unter Vorderkammerstellung seitlich dilatiert. Anhand eines Operationsvideos, das online zur Verfügung steht, wird die Operationstechnik detailliert dargestellt.

Vorteile des Münsteraner Standards
Der operative Zugang temporal-superior verspricht ein leichteres Handling, der Verzicht auf eine Tunnelneuanlage spart effektive Operationszeit. Weniger Endothelzellverluste bei nur einem liegenden Schlauch im Vergleich zu 2 Vorderkammerschläuchen sind potenziell zu erwarten.
Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England
Authors: Adiamah Alfred , Rashid Adil , Crooks Colin J. , Hammond John S. , Jepsen Peter , West Joe , Humes David J. 
Published: September 2023

Abstract
Introduction
The mortality risk after appendicectomy in patients with liver cirrhosis is predicted to be higher than in the general population given the associated risk of perioperative bleeding, infections and liver decompensation. This population-based cohort study aimed to determine the 90-day mortality risk following emergency appendicectomy in patients with cirrhosis.

Methods
Adult patients undergoing emergency appendicectomy in England between January 2001 and December 2018 were identified from two linked primary and secondary electronic healthcare databases, the clinical practice research datalink and hospital episode statistics data. Length of stay, re-admission, case fatality and the odds ratio of 90-day mortality were calculated for patients with and without cirrhosis, adjusting for age, sex and co-morbidity using logistic regression.

Results
A total of 40,353 patients underwent appendicectomy and of these 75 (0.19%) had cirrhosis. Patients with cirrhosis were more likely to be older (p < 0.0001) and have comorbidities (p < 0.0001). Proportionally, more patients with cirrhosis underwent an open appendicectomy (76%) compared with 64% of those without cirrhosis (p = 0.03). The 90-day case fatality rate was 6.67% in patients with cirrhosis compared with 0.56% in patients without cirrhosis. Patients with cirrhosis had longer hospital length of stay (4 (IQR 3–9) days versus 3 (IQR 2–4) days and higher readmission rates at 90 days (20% vs 11%, p = 0.019). Most importantly, their odds of death at 90 days were 3 times higher than patients without cirrhosis, adjusted odds ratio 3.75 (95% CI 1.35–10.49).

Conclusion
Patients with cirrhosis have a threefold increased odds of 90-day mortality after emergency appendicectomy compared to those without cirrhosis.
The basis of S–R learning: associations between individual stimulus features and responses
Authors: Verwey Willem B. 
Published: September 2023

AbstractThree experiments tested the hypothesis that response selection skill involves associations between individual stimulus features and responses. The Orientation group in Experiments 1 and 2 first practiced responding to the orientation of a line stimulus while ignoring its color, and the Color group practiced responding to the color of the line while disregarding its orientation. When in the ensuing test conditions the Orientation group responded to the color of the line, RTs and errors increased when the then irrelevant line orientation was inconsistent with practice. This confirmed that during practice, Orientation participants had developed orientation feature–response associations they could not fully inhibit. Yet, evidence for color feature–response associations was not observed in the Color group. This was attributed to orientation identification being faster than color identification, even after having practiced responding to colors. Experiment 3 involved practicing to three line stimuli with unique orientation and color combinations. It showed evidence for the independent development of orientation feature–response associations and color feature–response associations. Together, these results indicate that the typical RT reduction with practice in response selection tasks is caused in part by the capacity of participants to learn selecting responses on the basis of the stimulus feature that becomes available first.
Robot-assisted fluorescent sentinel lymph node identification in early-stage colon cancer
Authors: Sikkenk Daan J. , Sterkenburg Andrea J. , Burghgraef Thijs A. , Akol Halil , Schwartz Matthijs P. , Arensman René , Verheijen Paul M. , Nagengast Wouter B. , Consten Esther C. J. 
Published: September 2023

Abstract
Background
Patients with cT1-2 colon cancer (CC) have a 10–20% risk of lymph node metastases. Sentinel lymph node identification (SLNi) could improve staging and reduce morbidity in future organ-preserving CC surgery. This pilot study aimed to assess safety and feasibility of robot-assisted fluorescence-guided SLNi using submucosally injected indocyanine green (ICG) in patients with cT1-2N0M0 CC.

Methods
Ten consecutive patients with cT1-2N0M0 CC were included in this prospective feasibility study. Intraoperative submucosal, peritumoral injection of ICG was performed during a colonoscopy. Subsequently, the near-infrared fluorescence ‘Firefly’ mode of the da Vinci Xi robotic surgical system was used for SLNi. SLNs were marked with a suture, after which a segmental colectomy was performed. The SLN was postoperatively ultrastaged using serial slicing and immunohistochemistry, in addition to the standard pathological examination of the specimen. Colonoscopy time, detection time (time from ICG injection to first SLNi), and total SLNi time were measured (time from the start of colonoscopy to start of segmental resection). Intraoperative, postoperative, and pathological outcomes were registered.

Results
In all patients, at least one SLN was identified (mean 2.3 SLNs, SLN diameter range 1–13 mm). No tracer-related adverse events were noted. Median colonoscopy time was 12 min, detection time was 6 min, and total SLNi time was 30.5 min. Two patients had lymph node metastases present in the SLN, and there were no patients with false negative SLNs. No patient was upstaged due to ultrastaging of the SLN after an initial negative standard pathological examination. Half of the patients unexpectedly had pT3 tumours.

Conclusions
Robot-assisted fluorescence-guided SLNi using submucosally injected ICG in ten patients with cT1-2N0M0 CC was safe and feasible. SLNi was performed in an acceptable timespan and SLNs down to 1 mm were detected. All lymph node metastases would have been detected if SLN biopsy had been performed.
Qualitative Analyse von Patientenrückmeldungen zur prähospitalen Analgesie
Authors: Sander Henning , Häberle Nicola , Gnirke André , Nübling Matthias 
Published: September 2023

Zusammenfassung
Hintergrund
Die Ermittlung der Patientenzufriedenheit ist im Rahmen des Qualitätsmanagements bei der Rettungsdienst-Kooperation in Schleswig-Holstein (RKiSH) gGmbH von großer Bedeutung. Die vorliegende Auswertung ergänzt die Ergebnisse der quantitativen Befragung. Die folgende Auswertung führte zu der Erkenntnis, dass die Medikation keinen signifikanten Einfluss auf die Patientenzufriedenheit hat. Der Fragebogen wurde weiter validiert und die Freitextanalyse hier vorgestellt (siehe Online-Zusatzmaterial des Artikels).

Methode
118 Freitextantworten aus dem ursprünglichen Fragebogen wurden mit zwei Codern und einem selbst definierten Codesystem in die Kategorien positiv, negativ und keine Zuordnung verteilt. Die 515 Codierungen (codierte Freitextantworten) wurden in Bezug auf das Antwortverhalten bewertet.

Ergebnisse
Die positiven Anteile waren mit 61 % (n = 169) am höchsten. Die negativen Anteile hatten einen Wert von 27,1 % (n = 75). Ein Anteil von 11,9 % (n = 33) konnte keiner der beiden Kategorien zugeordnet werden. Die jeweils positiven und negativen Codierungen konnten dem Antwortverhalten im Fragebogen zugeordnet werden und unterscheiden sich voneinander.

Schlussfolgerung
Die Freitextantworten konnten die Ergebnisse weiter untermauern, brachten jedoch keine neuen Aspekte mehr hervor.
Do stroke services still show sex differences? A multicenter study
Authors: Nahas Nevine El , Shokri Hossam , Roushdy Tamer , Dawood Noha , Zaki Amr , Farhoudi Mehdi , Hokmabadi Elyar Sadeghi , Al Hashmi Amal , Brola Waldemar , Kosno Krystian , Falup-Pecurariu Cristian , Ciopleias Bogdan , Montaner Joan , Pérez-Sánchez Soledad , Mittal Manoj , Dowd Kandis , Banke Annie , Vigilante Nicholas , Siegler James , Ozdemir Atilla Ozcan , Aykac Ozlem , Kocabas Zehra Uysal , Melgarejo Donoband , Cardozo Analia , Peralta Lorena , Aref Hany , Caso Valeria 
Published: September 2023

Abstract
Background
The issue of sex differences in stroke has gained concern in the past few years. However, multicenter studies are still required in this field. This study explores sex variation in a large number of patients and compares stroke characteristics among women in different age groups and across different countries.

Methods
This multicenter retrospective cross-sectional study aimed to compare sexes regarding risk factors, stroke severity, quality of services, and stroke outcome. Moreover, conventional risk factors in women according to age groups and among different countries were studied.

Results
Eighteen thousand six hundred fifty-nine patients from 9 countries spanning 4 continents were studied. The number of women was significantly lower than men, with older age, more prevalence of AF, hypertension, and dyslipidemia. Ischemic stroke was more severe in women, with worse outcomes among women (p: < 0.0001), although the time to treatment was shorter. Bridging that was more frequent in women (p:0.002). Analyzing only women: ischemic stroke was more frequent among the older, while hemorrhage and TIA prevailed in the younger and stroke of undetermined etiology. Comparison between countries showed differences in age, risk factors, type of stroke, and management.

Conclusion
We observed sex differences in risk factors, stroke severity, and outcome in our population. However, access to revascularization was in favor of women.
Glucocorticoid-dependent multiple sclerosis overlapping anti-NMDA receptor encephalitis: a case report and literature review update
Authors: Yang Bo , Yu Nengwei 
Published: September 2023

Abstract
Background
Previous studies suggest a relationship between central nervous system inflammatory demyelinating diseases and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Also, the overlap between anti-NMDAR encephalitis and multiple sclerosis (MS) has been reported. However, the pathogenesis and clinical characteristics are still obscure.

Case presentation
A 33-year-old woman presented with diplopia and sensory ataxia at the onset. The cerebrospinal fluid (CSF) anti-NMDAR antibodies were positive (1:3.2), and nuclear magnetic resonance imaging (MRI) showed bilateral centrum ovale and lateral ventricle demyelinating lesions. Therefore, she was diagnosed with anti-NMDAR encephalitis. After administering intravenous immunoglobulin and oral prednisone, her lesions disappeared, and symptoms were relieved. The condition was maintained with a low dose of prednisone, but her lesions reappeared on MRI. Consequently, immunomodulatory therapy of mycophenolate mofetil was initiated. However, she developed dysarthria and right limb ataxia after 10 months with a positive CSF anti-NMDAR antibody (1:1) and positive oligoclonal band. The MRI showed symmetrical multiple demyelinating lesions. Considering the MS diagnosis, her neurological dysfunction again improved significantly after intravenous methylprednisolone. Unfortunately, her symptoms aggravated for the second time when teriflunomide was started. Finally, her condition was controlled again with oral prednisone.

Conclusions
Consistent with previous cases of overlapping anti-NMDAR encephalitis and MS, patients often show atypical symptoms on MRIs and immunological tests. The overlap cannot be arbitrarily treated because of the recurrence of previous diseases. Long-term follow-up, dynamic antibody monitoring, and MRI examination are crucial for these patients. The special dependency of the patient on glucocorticoids in this study has been rarely reported, which may guide the treatment of insensitivity to disease-modifying therapy in recurrent overlapping anti-NMDAR encephalitis and MS.
Parent-child school-related interactions and helplessness in maths: the role of maths self-efficacy
Authors: Hawrot Anna , Zhou Ji 
Published: September 2023

AbstractAlthough learned helplessness has a long research tradition, neither its contextual predictors nor the ways that they take effect are fully understood. This study inquired into the role of selected aspects of the home learning environment for academic helplessness. We tested whether three dimensions of parent-child school-related interactions—school-related assistance, structure, and responsiveness—predicted helplessness in maths. The study also verified whether student self-efficacy in maths partially mediated the relationships. The analyses were run on a sample of 6726 German secondary school students and used structural equation modelling. They confirmed that higher school-related assistance, structure, and responsiveness in Grade 7 were associated with lower helplessness in maths in Grade 7. Moreover, self-efficacy in maths was a partial mediator of these relationships. Additional analyses with helplessness in maths measured in Grade 9 revealed the same pattern of results for school-related assistance and responsiveness, but only an indirect link was present in the case of structure. The results highlight the protective role that parent-child interactions around school may play against academic helplessness.
Rebalance power and strengthen farmers’ position in the EU food system? A CDA of the Farm to Fork Strategy
Authors: Omar Aziz , Thorsøe Martin Hvarregaard 
Published: September 2023

AbstractThe Farm to Fork (F2F) Strategy at the heart of the European Union’s Green Deal set out to create a “just transition” towards a sustainable food system, with benefits for all actors. We conducted a critical discourse analysis (CDA) to explore discourses around power in the food system and farmers’ position in the communication and implementation of the Farm to Fork Strategy. Discourse analysis encapsulates various scientific methodologies for deciphering the meaning behind the creation and communication of different forms of language and identify power dynamics, amongst other aspects. We identified two prior discourses in one of the objectives of the European Union’s new Common Agricultural Policy (2023-27). Our analysis found that the discourses, namely “rebalance power in food system” and “strengthening farmers’ position in value chains,” are marginalized in favour of an innovation-investment discourse, indicative of greater financialization and technologization based on techno-finances fixes in transforming the European Union agri-food system. We argue that entities representing agri-business interests have been influential in the policymaking process and voices representing smallholder and medium-sized farmers’ transformational discourses have been excluded.
Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics
Authors: Oxana Semyachkina-Glushkovskaya , Alexander Shirokov , Inna Blokhina , Ivan Fedosov , Andrey Terskov , Alexander Dubrovsky , Maria Tsoy , Daria Elovenko , Viktoria Adushkina , Arina Evsukova , Valeria Telnova , Anna Tzven , Valeria Krupnova , Maria Manzhaeva , Alexander Dmitrenko , Thomas Penzel , Jürgen Kurths 
Published: September 2023

AbstractWith the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD. Photobiomodulation (PBM) is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal studies. However, the mechanisms of therapeutic effects of PBM for AD are poorly understood. In this study on mice, we demonstrate that photodynamic effects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels (MLVs) leading to suppression of lymphatic removal of beta-amyloid (Aβ) from the right lateral ventricle and the hippocampus. Using the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice, we discover that the 7-day course of PBM during deep sleep vs. wakefulness provides better restoration of clearance of Aβ from the ventricular system of the brain and the hippocampus. Our results shed light on the mechanism of PBM and show the stimulating effects of PBM on the brain lymphatic drainage that promotes transport of Aβ via the lymphatic pathway. The effects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD.
Graphical Abstract
Comparison of the Felt Earthquakes since Historical Times with NCS Catalogue and ISR Telemetry Network in Gujarat (2006 to date)
Authors: Srivastava H.N. , Prajapati Sanjay K. , Rajkumar  
Published: September 2023

Abstract
Different catalogues of earthquakes are available for the Indian region besides regional catalogues for the Gujarat region. The limitations of these and other historical catalogues have been discussed in this paper for earthquake hazards and other studies. Keeping in view that these historical catalogues have been successful in explaining the recent occurrence of a few earthquakes like Coimbatore (1900), Hyderabad (1983), Bangaluru (1985) and Jabalpur (1997), the study has been extended to the Gujarat region. In this paper, therefore, an attempt has been made to correlate the historical data of the felt earthquakes in the Gujarat region from all the available sources with instrumental data to examine the recurrence of the earthquakes. It has been found that in addition to the seismically active Kutch region and Narmada and Cambay rifts, there is a tendency for earthquakes to recur in many districts of Gujarat for which felt data from historical times is available. The seismicity map prepared by the Institute of Seismological Research (ISR), Gandhinagar based on the Seismic Telemetry (2006-2020) shows scattered seismicity over the whole of Gujarat region besides active seismicity in the Kutch region. This data when combined with that from the catalogue prepared by the National Centre of Seismology provides greater confidence for earthquake hazard studies It has also been found that the coastal regions of Saurashtra and south Gujarat are more prone to swarm types of earthquakes.
Non-carcinogenic Health Risk Assessment of Fluoride and Nitrate of Groundwater – A Case Study of the Central Dry Zone of Chikkanayakanahalli Taluk, Tumkur District, Karnataka
Authors: Pushpa K.L. , Ravikumar P. , Prakash K.L. 
Published: September 2023

Abstract
Forty-two groundwater samples were randomly collected from Chikkanayakanahalli taluk during the pre-monsoon season of 2022 and were analysed for Fluoride and Nitrate levels using APHA standard methods. USEPA method was employed to assess the non-carcinogenic health hazards associated with exposure to NO3– and F– from drinking water consumption by computing estimated daily intake (EDI), hazard quotient (HQ) and total hazard index (THI). HQnitrate &gt; 1 through the ingestion pathway was observed in 14.28 and 4.76 % of the groundwater samples, respectively, for children and Teenagers, while HQfluoride &gt; 1 for children was reported in 16.66% of the groundwater samples. Higher mean values of HQFluoride over HQNitrate supported added contribution of fluoride in groundwater of the study area in the non-carcinogenic human health risk over nitrate among different age groups of the local population. Overall, the average THI values were 0.205, 1.452, 1.025 and 0.821, respectively, for Infants, children, Teenagers, and Adults, and their trend was in the order: children &gt; Teenagers &gt; Adults &gt; Infants. It was found that 90.5%, 54.8%, and 14.3% of the samples progressed beyond the standard limit (THI = 1) for children, Teenagers, and adults, respectively, illustrating that children are more prone to non-carcinogenic risks than other age groups. Further, NHHR of F- and NO3- in groundwater was higher for children, attributed to their lower body weight over teenagers and adults, besides average water consumption rates.
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Authors: Henriques Patrícia , Bicker Joana , Carona Andreia , Miranda Margarida , Vitorino Carla , Doktorovová Slavomíra , Fortuna Ana 
Published: September 2023

Abstract
Purpose
Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal delivery, while comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, with the corresponding physical blends with crystalline drug.

Methods
Formulations of piroxicam were manufactured using varied polymer and particle engineering strategies and evaluated through in vitro drug release and ex vivo permeation studies, as well as nasal deposition and in vivo pharmacokinetic studies.

Results
ASD with hydroxypropyl methylcellulose (HPMC) showed enhanced drug release and permeation, compared to polyvinylpyrrolidone/vinyl acetate formulations and blends. Nasal deposition of HPMC chimeral agglomerates suggested off-target deposition. In vivo pharmacokinetic studies revealed that spray-dried HPMC-containing microparticles exhibited the highest maximum plasma concentration (Cmax) and the lowest time to attain it (tmax). In vitro release rate and in vivo absorption rate were correlated as well as tmax and in vitro performance. When excluding the formulation with least nasal targeted deposition, in vitro release and ex vivo permeation performance were also correlated with Cmax and area under the drug concentration-time curve (AUC) from 0 to 1 h, with R2 > 0.89.

Conclusion
ASD for nasal delivery provide fast drug absorption, which depends on the supersaturation ability of the polymer employed. In vitro-in vivo correlations suggested that in vitro release and ex vivo permeation studies are predictive tools regarding nasal absorption.