bluuebunny/crossref_metadata_2025_split huggingface dataset:
D3 lymph node dissection improves survival outcomes in patients with cT2 colorectal non-well-differentiated adenocarcinoma
Authors: Wang Liming , Song Bolun , Chen Yinggang , Hirano Yasumitsu 
Published: August 2023

Abstract
Background: The extent of lymphadenectomy appropriate for patients with cT2 colorectal cancer (CRC) remains controversial. This study was conducted to compare survival outcome of patients with cT2 CRC after D3 or D2 lymph node dissection (LND).
Methods: Qualifying subjects (N=590) had undergone radical colorectal resections for cT2 CRC and weregrouped by tumor histological type as either well-differentiated (WDA) or non-well-differentiated (nWDA) adenocarcinoma. Each group was further stratified as D3 or D2 LND, according to extent of lymph node dissection. Propensity score matching (PSM) was applied to balance potential confounding factors, identifying independent prognostic risk factors by Cox regression analysis. Primary outcome measures were overall survival (OS), cancer-specific survival (CSS) and relapse-free survival rate (RFS).
Results: Prior to PSM, OS and CSS differed significantly (p=0.001 and p=0.021, respectively) for D3 and D2 LND subsets of the nWDA group. Estimated hazard ratios (HRs) for OS and CSS were 3 (95% confidence interval [CI]: 1.3-6.8; p=0.0084) and 3.2 (95% CI: 1-10; p=0.047), respectively in the D3 LND subset. After matching, significant differences in OS (p=0.007) and CSS (p=0.012) were also observed, with corresponding estimated HRs of 4 (95% CI: 1.2-14; p=0.028) and 16 (95% CI: 1.2-220; p=0.034). In the WDA group, D2 and D3 LND procedures displayed similar favorable prognoses before and after matching. Postoperative complications emerged as independent risk factors for prognosis in the WDA group of patients with cT2 CRC.
Conclusions:
D3 LND improved survival outcomes in patients with non-well-differentiated cT2 colorectal adenocarcinoma. In patients with well-differentiated cT2 adenocarcinoma, D3 LND was preferential to reduce perioperative complications.
Life satisfaction, Hope and Self Esteem among Working and Non-working Parous married women living in joint families
Authors: Mishra Rupa , Gupta Shubhangi 
Published: August 2023

Abstract
The aim of the current study is to investigate if there are differences in hope, life satisfaction, and self-esteem between working and non-working married women living in joint families. The sample had 144 parousmarried women working as well as non-working women living in joint families. The age range was 24–55 years. Participants were from urban and rural areas. The hope scale, life satisfaction scale, and self-esteem scale were used. Results showed that there are considerable differences in hope, life satisfaction, and self-esteem between working and non-working married women living in joint families. Self esteem and life satisfaction have a significant positive relationship with hope. Therapies and counselling may help improve self-esteem and life satisfaction. Findings have vital implications for practice and underscore the requirement to help and encourage married women in their lifestyle. The results highlight the need for mental well-being promotion and also prevent low self-esteem in non-working women as an appropriate response to enhance their hope and life satisfaction. There is a requirement to be hopeful and positive in order to deal with low self-esteem and low life satisfaction.
Transcatheter ventricular septal defect closure with LifetechTM Konar-MF occluder in infants under ten kilograms with only using venous access
Authors: Ece İbrahim , Bağrul Denizhan , Kavurt Ahmet Vedat , Terin Harun , Torun Gülşah , Koca Serhat , Gül Ayşe Esin Kibar 
Published: August 2023

Abstract
Transcatheter closure of VSD remains a complex procedure in infants with technical challenges and carries the risk of significant complications, due to its complex anatomical morphology and closed proximity to the atrioventricular valves and the conduction system. In this article, we presented transcatheter VSD closure in infants under ten kilograms using the Lifetech Konar-MF device via only venous route without TEE guidance and arterial access. Between January 2020 and January 2023, a total of 34 patients weighing less than 10 kg who underwent transcatheter VSD closure antegradely with Lifetech Konar-MF device were included in the study. The mean age of the patients was 8.1 (3.5–35) months. Average weight was 6.5kg (range 4.5–10 kg). VSD was perimembranous in 27 patients (79.4%). Successful device placement was achieved in all 34 patients. However, device embolization occurred in three patients. One of the patients was successfully implanted with a one size larger device, the surgical closure was performed other two cases. TR occurred in seven patients (20.6%) after releasing devices. None of the patients developed complete heart block. Right bundle branch block developed in two patients. Residual shunt was observed in 9 patients (six small, two moderate and one large). During follow-up, residual shunt disappeared in six of these patients and only mild residual shunt remained in the other four patients which have not required any further intervention. Transcatheter closure of VSD with Lifetech Konar-MF device is safe and effective in infants less than ten kilograms via only venous access with a high success rate and low complication rate. In these patients, transcatheter VSD closure can be performed by excluding the risk of complications that may occur due to AV loop formation, arterial intervention, endotracheal intubation and TEE use.
New infinite classes of 0-APN power functions over F2n
Authors: Zhou Huijuan , Zhuo Zepeng , Chen Guolong 
Published: August 2023

Abstract
Constructing new families of APN functions is an important but difficult topic. Up to now, only 6 infinite families of power APN functions and 14 infinite families of APN polynomials are found. In order to study APN functions, partially APN functions have attracted plenty of researchers’ particular interests recently. Yoshiara demonstrated CCZ equivalence between APN power functions can transform the cyclotomic equivalence problem in characteristic 2. And then Dempwolff generalized Yoshira’s result to any characteristic p. In this paper, we propose several new infinite classes of 0-APN power functions over F2n by using the multivariate method and resultant elimination. And the exponents of the power functions comes from the study of partially APN functions by Budaghyan et al. Furthermore, with the help of Magma experiments and established conclusions, we show that these 0-APN power functions are CCZ-inequivalent to the known ones.
MSC Classification: 12E05 , 94C10
Knowledge, Attitudes, and Practices of Health Professions Students on Mentorship: a cross-sectional study at a sub-Saharan African medical school
Authors: Tamale Elvis , Atuhairwe Irene , Ssemwogerere Arnold , Muhimbura Brian , Atimango Lorna , Malinga Paddy Derrick , Mulungi Jonathan , Ssekitto Joseph , Naigaga Josephine , Kintu Timothy Mwanje , Masood Kiran Mitha , Ohuruogu Victor , Ngonzi Joseph 
Published: August 2023

Abstract
Background Mentoring is “a process for the informal transmission of knowledge, social capital, and support perceived by the recipient as relevant to work, career, personal, or professional development”. Students pursuing health-related courses need access to mentorship and its benefits during their formative academic and career states. However, in Sub-Saharan Africa, many institutions have not fully embraced this despite the benefits of mentorship.Aim The primary purpose of this study was to assess medical students’ knowledge about mentorship and explore their attitudes and practices toward mentorship.Methodology We held an online cross-sectional study utilizing a pre-tested self-reported questionnaire targeting health professional students in the faculty of medicine under close supervision and review by the Dean Faculty of Medicine Mbarara University of Science and Technology. The collected data were coded and summarized using descriptive statistics and thematic analysis.Results Two hundred eighty-three (283) students participated in this study. Of this group, 79.9% were aware of mentorship, 61% were willing to commit 1–2 hours a week for mentorship, and Zoom was the preferred mode of communication; 98.2% expressed the need for a structured student-led hybrid mentorship program.Conclusion Mentorship at Mbarara University of Science and Technology was considered necessary by health professions students in the Faculty of Medicine.Recommendation Future studies should explore accessibility to mentorship and the effectiveness of existing mentorship processes.
Exploring the Association between Genetic variant rs5925 in LDLR Gene and the Incidence of T2DM with CAD in Iraqi Population. A case-control Study
Authors: Salman Mohammed N , Al-Kashwan Thekra Abid Jaber , aljanabi Abdulhussein Faraj Alwan 
Published: August 2023

Abstract
Background
The crucial function of the low-density lipoprotein receptor (LDLR) is to regulate cellular cholesterol levels. Changes in the LDLR gene can result in a notable rise in LDL cholesterol in the blood, potentially increasing the likelihood of T2DM with CAD, which involves atherosclerosis and coronary heart problems. Additionally, it impacts lipid levels in the bloodstream among Iraq's population. This study primarily aimed to explore the possible link between the LDLR rs5925 variation and cardiovascular disease (CVD) in individuals with type 2 diabetes in Iraqi population.
Method
The research involved a sample of 400 participants, categorized into two groups: 200 individuals with both Type 2 Diabetes Mellitus (T2DM) and coronary artery disease, and 200 healthy individuals without these medical conditions. The main objective of the investigation was to explore the potential link between a specific variation in the LDLR gene known as rs5925 and the susceptibility to these ailments. To achieve this, a logistic regression analysis was conducted to determine odds ratios (OR) and their corresponding 95% confidence intervals (CI). In this instance a case-control study employed the Allele Discrimination/SNP's Real-Time PCR TaqMan technique, utilizing the Mx3005P QPCR System to genotype the polymorphism.
Result
In the analysis of the frequencies of the LDLR gene polymorphism, rs5925 T/C, using the co-dominant model, it was observed that individuals affected by both Type 2 Diabetes (T2DM) and coronary artery disease (CAD) showed a notable increase in heterozygous genotype (TC) compared to the control group (adjusted odds ratio [OR] = 3.2, 95% confidence interval [CI] = 2.03–4.9, p < 0.0001). Additionally, it is worth noting that the homozygous recessive genotype (CC) also demonstrated a significant increase when compared to the control group (OR = 10.5, CI 95% = 2.6–6.1, p < 0.01). These findings suggest that individuals with the genotypes (TC) may be three times higher risk of developing Type 2 Diabetes (T2DM) along with coronary artery disease (CAD) compared to those with the wild type genotype (TT) as well as (CC) may be at nearly ten times.
Conclusions
This study is the inaugural instance of showing a link between the LDLR gene polymorphism and a heightened vulnerability to cardiovascular disease among patients with type 2 diabetes. The results of our study indicate an association between the variation in the LDLR gene rs5925 and the occurrence of both T2DM and CAD, also impacting lipid profiles.
Some New Copson-Type Inequalities on Time Scales Delta Calculus
Authors: Ahmed A. M. , Saied A. I. , Rezk H. M. 
Published: August 2023

Abstract
In this research, we establish some new generalizations of dynamic inequalities of Copson-type on time scales delta calculus by applying Hölder’s inequality, Minkowski’s inequality, chain rule and the properties of power rules on time scales. As special cases of our results (when T = R), we get the continuous analouges of inequalities that proved by Mohapatra and Vajravelu [8] and when T = N 0 , the results to the best of the authors’knowledge, are essentially new. 2010 Mathematics Subject Classi…cation: 26D10, 26D15, 34N05, 47B38, 39A12.
RETRACTED: Evolution in medical education: Perception of evolution among medical students and resident training doctors in Turkey
Authors: Şahin Mustafa Emre , Kaya Ferah Diba , Oral Dilan , Düzova Halil , Günbayı İlhan , Çıplak Battal 
Published: August 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Unveiling the oncogenic role of lncRNA 91H in liver Cancer: Implications for proliferation, migration, invasion, and epithelial-mesenchymal transition
Authors: Mo Zhiyuan , Wang Zhuangqiang 
Published: August 2023

Abstract
Objective
This study aimed to investigate the functional role of long ncRNA (lncRNA) 91H in liver cancer tumorigenesis, focusing on its effect on cell proliferation, apoptosis, cell cycle progression, migration, invasion, and epithelial-mesenchymal transition (EMT).
Methods
Liver cancer tissues and cell lines were analyzed for lncRNA 91H expression using quantitative methods. The functional role of 91H was assessed by silencing its expression in liver cancer cells. Cell proliferation was evaluated by measuring apoptosis induction and cell cycle progression. The migration and invasion capabilities of liver cancer cells were assessed and their impact on EMT was examined.
Results
Significantly higher levels of lncRNA 91H were observed in liver cancer tissues and cell lines than in normal cells. Silencing of 91H in liver cancer cells led to a notable reduction in cell proliferation by inducing apoptosis and arresting the cell cycle. Liver cancer cells with decreased 91H expression exhibited diminished migration and invasion abilities, suggesting a role for 91H in promoting these processes. Furthermore, 91H knockdown weakened EMT in liver cancer cells, indicating its involvement in modulating this critical cellular transition.
Conclusion
The findings of this study demonstrated that lncRNA 91H plays an oncogenic role in liver cancer. Its overexpression in liver cancer tissues and cell lines is associated with increased proliferation, migration, invasion, and EMT. Silencing 91H resulted in the inhibition of cell proliferation and reduced metastatic potential, suggesting its potential prognostic and therapeutic value in liver cancer. Further exploration of the molecular mechanisms underlying the involvement of 91H may provide valuable insights into liver cancer progression, and contribute to the development of more effective therapeutic strategies.
Exploratory laparotomy diagnostic and management mainstay in a case of huge ovarian cyst torsion on late post postpartum period, at resource limited set up of leku general hospital,sidama,Ethiopia, case report
Authors: Kibret Asfaw , Bayu Efrem 
Published: August 2023

Abstract
Background: Huge ovarian cyst is a rare occurrence in postpartum period. Once existing ovarian cyst passes the pregnancy period, it is a risk for torsion on postpartum days when the gravid uterus involuted.Here we present a case of huge ovarian cyst torsion on late post partum period which is diagnosed and managed in our resource limited set up.
Case presentation: this is a case of 30yrs old female patient who is on her 30th post partum date after she gave alive fetus at home. Then she noticed that her abdomen failed to decrease after delivery and waited for spontaneous decrement and lastly she visited health center for the newly developing worsened pain since last 3 days of her presentation to health center.
Conclusion: This case reports that huge ovarian cyst accompanied pregnancy might not affect the pregnancy and vaginal delivery is possible but torsion is common in this case due to the involution of the postpartum uterus. Exploratory laparotomy in low resource set up is still the main stay for diagnosis and management of such emergency cases.
Effect of exposure to ambient air pollution on gynecological cancer: A systematic review
Authors: Murithi Rachael Gakii , Lu Chan 
Published: August 2023

Abstract
Background
The importance of gynecological cancer and air pollution awareness cannot be overemphasized. Various studies undertaken worldwide have found that exposure to atmospheric pollutants can lead to high morbidity and mortality due to gynecological cancer. Hence, it is critical to address this issue for the prevention and reduction of gynecological cancers.
Objective
This review was conducted to objectively assess the effect of exposure to ambient air pollution on gynecological cancer and its related factors among women.
Methods
A systematic review and meta-analysis of quantitative research were conducted. We searched 5 electronic databases: CINAHL (EBSCO Academic Search Premier); Google Scholar; Embase; PubMed and Web of Knowledge to identify relevant studies for inclusion from January 2011 to December 2021. The quality of each study included for meta-analysis was determined using the Joanna Briggs Institute Critical appraisal tool.
Results
18,324 records were identified from the electronic data search. 16,535 records were filtered systematically. Finally, 12 studies involving 5 population-based cross-sectional studies using secondary data from demographic health surveys conducted prior, 2 cohort studies, 3 articles are case-control studies, 1 ecological study, and 1 meta-analysis were added in the final analysis. Accordingly, the overall point estimate of gynecological (cervical, ovarian, and endometrial) cancer among women worldwide was 50% (95%CI: 43 ~ 57%). High heterogeneity (I2 = 99.72%, p < 0.001) was noticed which could be due to factors not explored in this review. The factors commonly associated with gynecological cancer were occupation, procreation, age, diabetes, the number of births, drinking, a family history of cancer, menstrual cycle, and environmental tobacco smoke (ETS).
Conclusion
Long-term air pollution exposure has a significant impact on the occurrence and development of gynecological tumors. The interaction between ambient air pollution and sensitive determinants can significantly increase the risk of gynecological tumors. Air pollution exposure may be high in most countries worldwide. Hence, there was heterogeneity in the effect of exposure to ambient air pollution on gynecological cancer.
An Intelligent Camera Based Eye Controlled Wheelchair System: Haar Cascade and Gaze Estimation Algorithms
Authors: v viswanatha , A.C Ramachandra , Reddy Gowkanapalli Lokeshwar , Reddy A V Sai Tharun , Reddy Biyyam Pranay Kumar , Kiran Gavvala Bhanu 
Published: August 2023

Abstract
This article proposes a system that aids people
with disabilities. An Electric Eye Controlled Wheelchair System
is built to help disabled people. With the designed system,
disabled people can move effortlessly without support from
others. The system uses image acquisition wherein the image of
the eye is processed to find out the gaze direction of the eye using
Haar cascade and gaze estimation algorithms and hence
wheelchair moves according to the direction of eyeball
movement. The gaze estimation algorithm is so precise and one
single algorithm does the job of what two algorithms (Canny
Edge detection, Hough Transform) are supposed to do and to
execute the same task. With this technique, a disabled person
can steer their wheelchair with their eye movement. The
webcam is placed in Infront of the person which captures the
live movements, and an image processing technique is used to
track the position of the pupil in both eyes with the help of a
raspberry pi processor. The image processing technique used
here is Gaze tracking which uses Open CV. The gaze tracking
tracks pupil movement and depicts its coordinates. According to
pupil motion, the motor driver will be instructed to go forward,
left, and right. A blink instruction is used to stop the wheelchair
when the person blinks. Additionally, a front-mounted
ultrasonic sensor that can detect obstructions and automatically
halt wheelchair movement is mounted for safety reasons. The
system is monitored by a Raspberry Pi device, which lowers the
cost.
Molecular characterisation and potential pathogenicity analysis of Acanthamoeba isolated from recreational lakes in Peninsular Malaysia
Authors: Abdul Halim Rohaya , Mohd Hussain Rosnani Hanim , Aazmi Shafiq , Halim Hasseri , Ahmed Khan Naveed , Siddiqui Ruqaiyyah , Shahrul Anuar Tengku 
Published: August 2023

Abstract

The present study aims to identify the Acanthamoeba genotypes and their pathogenic potential in three recreational lakes in Malaysia. Thirty water samples were collected by purposive sampling between June and July 2022. Physical parameters of water quality were measured in situ while chemical and microbiological analyses were performed in the laboratory. The samples were vacuum filtered through nitrate filter, cultured onto non-nutrient agar and observed microscopically for amoebic growth. DNAs from positive samples were extracted and made to react with polymerase chain reaction using specific primers. Physiological tolerance tests were performed for all Acanthamoeba-positive samples. The presence of Acanthamoeba was found in 26 of 30 water samples by PCR. The highest rate in lake waters contaminated with amoeba was in Biru Lake (100%), followed by Titiwangsa Lake (80%) and Shah Alam Lake (80%). ORP, water temperature, pH and DO were found to be significantly correlated with the presence of Acanthamoeba. The most common genotype was T4. Temperature- and osmo-tolerance tests showed that 8 (30.8%) of the genotypes T4, T9 and T11 were highly pathogenic. The presence of genotype T4 in habitats related to human activities supports the relevance of this amoeba as a potential public health concern.
Coagulant dosage prediction in the water treatment process
Authors: Tochio Eloiza Laisla Lino , do Nascimento Bruno Cézar , Lautenschlager Sandro Rogério 
Published: August 2023

Abstract
Coagulation is an important water treatment step in a water treatment plant (WTP). Jar tests are performed to determine the required dose of coagulant; however, these tests are slow to be performed and do not give a response in real-time to changes in raw water quality that changes abruptly during the day. To overcome this limitation, this research developed artificial neural network (ANN) models, using full-scale WTP data that served to calibrate the model and then predict the coagulant dosage, considering raw water as data input, in compliance with the treated water quality parameters. The best model was able to predict the coagulant dosage with a mean squared error of 0.016 and a correlation coefficient equal to 0.872. These results corroborate to promote coagulant dosage automation in WTPs, making it clear that ANN models allow a faster response in dosage definition and reduce the need for human interaction in the process.