bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining novel trait and neurocognitive frameworks to parse heterogeneity in borderline personality disorder
Authors: Hanegraaf Lauren , Paton Bryan , Hohwy Jakob , Verdejo‐Garcia Antonio 
Published: January 2023

AbstractObjectiveBorderline Personality Disorder (BPD) diagnosis comprises several constellations of trait, neurocognitive, and psychosocial alterations. Dimensional models of psychopathology provide new opportunities to parse heterogeneity and create a stronger interface between individual characterization and psychosocial outcomes. However, dimensional models have focused on either traits or neurocognitive features, lacking integration to capture the multifaceted nature of BPD.MethodWe assessed 100 participants with BPD using a combination of tools stemming from trait (Alternative Model for Personality Disorders) and neurocognitive models (Research Domain Criteria; RDoC) to examine if trait‐derived subgroups display distinctive social‐processing and psychosocial profiles. We used two complementary analytical approaches: person‐centered (k‐means clustering) and construct‐based (multiple factor analysis).ResultsOur person‐centered approach identified four subgroups with separable internalizing, detached, externalizing, and low psychopathology trait profiles. These profiles revealed distinctive patterns of affiliation, emotion recognition and mentalization performance in RDoC tasks, and psychosocial measures of quality of life and social connectedness. RDoC‐based measures showed close construct proximity with negative affectivity, disinhibition, and antagonism trait domains, relative to the detachment domain, which had close proximity with self‐knowledge.ConclusionsAltogether, findings support consilience between trait‐based and neurobiological frameworks and suggest that trait models are useful to parse BPD heterogeneity leading to unique social functioning profiles.
How and why people want to be more moral
Authors: Sun Jessie , Wilt Joshua , Meindl Peter , Watkins Hanne M. , Goodwin Geoffrey P. 
Published: January 2023

AbstractObjectiveWhat types of moral improvements do people wish to make? Do they hope to become more good, or less bad? Do they wish to be more caring? More honest? More loyal? And why exactly do they want to become more moral? Presumably, most people want to improve their morality because this would benefit others, but is this in fact their primary motivation? Here, we begin to investigate these questions.MethodAcross two large, preregistered studies (N = 1818), participants provided open‐ended descriptions of one change they could make in order to become more moral; they then reported their beliefs about and motives for this change.ResultsIn both studies, people most frequently expressed desires to improve their compassion and more often framed their moral improvement goals in terms of amplifying good behaviors than curbing bad ones. The strongest predictor of moral motivation was the extent to which people believed that making the change would have positive consequences for their own well‐being.ConclusionsTogether, these studies provide rich descriptive insights into how ordinary people want to be more moral, and show that they are particularly motivated to do so for their own sake.
Genomic and phenotypic signatures of bacteriophage coevolution with the phytopathogen Pseudomonas syringae
Authors: Hernandez Catherine A. , Delesalle Véronique A. , Krukonis Greg P. , DeCurzio Jenna M. , Koskella Britt 
Published: January 2023

AbstractThe rate and trajectory of evolution in an obligate parasite is critically dependent on those of its host(s). Adaptation to a genetically homogeneous host population should theoretically result in specialization, while adaptation to an evolving host population (i.e., coevolution) can result in various outcomes including diversification, range expansion, and/or local adaptation. For viruses of bacteria (bacteriophages, or phages), our understanding of how evolutionary history of the bacterial host(s) impacts viral genotypic and phenotypic evolution is currently limited. In this study, we used whole genome sequencing and two different metrics of phage impacts to compare the genotypes and phenotypes of lytic phages that had either coevolved with or were repeatedly passaged on an unchanging (ancestral) strain of the phytopathogen Pseudomonas syringae. Genomes of coevolved phages had more mutations than those of phages passaged on a constant host, and most mutations were in genes encoding phage tail‐associated proteins. Phages from both passaging treatments shared some phenotypic outcomes, including range expansion and divergence across replicate populations, but coevolved phages were more efficient at reducing population growth (particularly of sympatric coevolved hosts). Genotypic similarity correlated with infectivity profile similarity in coevolved phages, but not in phages passaged on the ancestral host. Overall, while adaptation to either host type (coevolving or ancestral) led to divergence in phage tail proteins and infectivity patterns, coevolution led to more rapid molecular changes that increased bacterial killing efficiency and had more predictable effects on infectivity range. Together, these results underscore the important role of hosts in driving viral evolution and in shaping the genotype–phenotype relationship.
The benefits and costs of U.S. employer COVID‐19 vaccine mandates
Authors: Ferranna Maddalena , Robinson Lisa A. , Cadarette Daniel , Eber Michael R. , Bloom David E. 
Published: January 2023

AbstractIn 2021, the Biden Administration issued mandates requiring COVID‐19 vaccinations for U.S. federal employees and contractors and for some healthcare and private sector workers. These mandates have been challenged in court; some have been halted or delayed. However, their costs and benefits have not been rigorously appraised. This study helps fill that gap. We estimate the direct costs and health‐related benefits that would have accrued if these vaccination requirements had been implemented as intended. Compared with the January 2022 vaccination rates, we find that the mandates could have led to 15 million additional vaccinated individuals, increasing the overall proportion of the fully vaccinated U.S. population from 64% to 68%. The associated net benefits depend on the subsequent evolution of the pandemic—information unavailable ex ante to analysts or policymakers. In scenarios involving the emergence of a novel, more transmissible variant, against which vaccination and previous infection offer moderate protection, the estimated net benefits are potentially large. They reach almost $20,000 per additional vaccinated individual, with more than 20,000 total deaths averted over the 6‐month period assessed. In scenarios involving a fading pandemic, existing vaccination‐acquired or infection‐acquired immunity provides sufficient protection, and the mandates’ benefits are unlikely to exceed their costs. Thus, mandates may be most useful when the consequences of inaction are catastrophic. However, we do not compare the effects of mandates with alternative policies for increasing vaccination rates or for promoting other protective measures, which may receive stronger public support and be less likely to be overturned by litigation.
Mathematics and science teacher educators' use of representations of practice: A mixed methods study
Authors: Austin Christine K. , Kosko Karl W. , Heisler Jennifer L. 
Published: January 2023

AbstractThis study sought to explore math and science teacher educators' use of various media to represent practice within methods courses. There is little understanding of why certain media is used over other representations and the rationale for these choices. Specifically, the study focused on the prevalence and familiarity of teacher educators with comics and animations, standard videos, and 360 videos. This mixed methods study utilized a survey and interviews to ascertain math and science teacher educators' level of familiarity and perceived usefulness of representations of practice. Results indicate that standard video is by far the most used representation of practice in methods classes with three themes explaining this finding: access to representations of practice, dimensions of representation, and pertinacity of using representations. Familiarity with representations of practice relates to teacher educators' perceptions of access thereby indicating a need for teacher educators to have better access to representations. Implications of this study include supporting current literature about the relationship between the level of familiarity and perceived usefulness in media along with the potential need for a central platform that houses these representations of practice resources for teacher educators.
Leakage Flow Impact on Shrouded Stator Cavity Flow Topology and Associated High-Speed Axial Compressor Stage Performance
Authors: Babin Cedric , Ottavy Xavier , Fontaneto Fabrizio 
Published: January 2023

AbstractThis paper presents the investigation of realistic cavity leakage flow for the von Karman Institute for Fluid Dynamics H25 axial compressor stage, equipped with a shroud cavity of average Reynolds number Rer = 2.2 * 106 and average aspect ratio G = 0.06. On top of overall performance measurements, time averaged data from unprecedented experimental dataset are used to characterize the stator hub shroud cavity flow field and its interaction with the power stream. The sensitivity of the stage performance and stability as well as the cavity flow topology is evaluated against injection conditions, compressor throttling, and compressor speed. Parametric steady RANS simulations of the stage under injection are used to support the findings and state on the relevance of such approach in the preliminary design phase of axial compressor components. As an example, a stage efficiency reduction of 0.97% for a leakage fraction of 0.56% at design point is retrieved. This performance drop is attributed to the effect of cavity flow on: the blockage ratio, the boundary layer skewness, and total temperature increase at stator row inlet. It is also presented that there is a mutual interaction between the cavity geometry and the cavity flow field organization. The injection homogenizes the cavity flow field and the associated pressure gradient. The various operating conditions presented also demonstrate that the cavity flow studied is, on average (i.e., time), sensitive to changes in compressor rotation speed and changes in stage loading.
“It’s Avoiding Getting Sued for Concussion for Those Kids”: Pedagogical Responses of Youth Soccer Coaches to New Guidelines on Heading
Authors: Barnes Colin S. , Curtner-Smith Matthew D. 
Published: January 2023

Purpose: To describe nine youth soccer coaches’ pedagogical responses to the implementation of the new guidelines on heading introduced by the United States Soccer Federation. The specific research questions we attempted to answer were: (a) What were the coaches’ perspectives and practices regarding the coaching of heading? and (b) What factors shaped the coaches’ perspectives and practices? Method: The theoretical framework employed was occupational socialization. Data were collected using four qualitative techniques and reduced to themes using analytic induction and constant comparison. Findings: Key findings were that the coaches fell into one of three groups: rejectors, acceptors, and skeptics. Differences in the coaches’ acculturation, professional socialization, and organizational socialization were responsible for the coaches’ differing responses to the new guidelines on heading. Conclusions: Should they transfer to other coaches, these findings should help coach educators to develop stronger programs.
Prevalence of, and factors associated with, diabetes mellitus in people with severe mental illness attending a multidisciplinary, outpatient cardiometabolic health assessment service
Authors: Lambert Tim , Middleton Tim , Chen Roger , Sureshkumar Premala 
Published: January 2023

IntroductionEvaluate the prevalence of, and factors associated with, diabetes in people with severe mental illness (SMI) attending the Collaborative Centre for Cardiometabolic Health in Psychosis (ccCHiP) tertiary referral clinics.Research design and methodsAdult patients attending an initial ccCHiP clinic consultation (2014–2019) were studied. Diabetes was defined by an hemoglobin A1c of ≥6.5%, fasting blood glucose of ≥7.0 mmol/L, or a self-reported diagnosis of diabetes and prescription of antihyperglycemic medication.ResultsOver 5 years, 1402 individuals attended a baseline consultation. Mean age of 43.9±12.8 years, 63.1% male and 63.5% had a diagnosis of schizophrenia. Prevalence of diabetes was 23.0% (n=322); an additional 19.5% fulfilled criteria for pre-diabetes. Of those with diabetes, 15.8% were newly diagnosed. Of those with pre-existing diabetes, 84.5% were receiving treatment with antihyperglycemic medication. Over 94% of individuals with diabetes had dyslipidemia; half were current smokers; and 46.4% reported sedentary behavior. On multivariate analysis, diabetes was associated with older age, Aboriginal, Indian or Middle Eastern maternal ethnicity, elevated waist-to-height ratio, family history of diabetes and use of antipsychotic medication.ConclusionPrevalence of diabetes mellitus in this multiethnic cohort with SMI is significantly higher than the Australian population. Targeted interventions via an assertive integrated approach are required to optimize cardiometabolic health in this population.
Negative impact of the pandemic on hospital admissions, morbidity and early mortality for acute cirrhosis decompensation
Authors: Gananandan Kohilan , Phillips Alexandra , Chikhlia Anmol , Old Hannah , Sim Sharmaine Jia Ying , Thakur Niharika , Hussain Ishrat , Kazankov Konstantin , Mookerjee Rajeshwar P 
Published: January 2023

IntroductionThe global pandemic has diverted resources away from management of chronic diseases, including cirrhosis. While there is increasing knowledge on COVID-19 infection in liver cirrhosis, little is described on the impact of the pandemic on decompensated cirrhosis admissions and outcomes, which was the aim of this study.MethodsA single-centre, retrospective study, evaluated decompensated cirrhosis admissions to a tertiary London hepatology and transplantation centre, from October 2018 to February 2021. Patients were included if they had an admission with cirrhosis decompensation defined as new-onset jaundice or ascites, infection, encephalopathy, portal hypertensive bleeding or renal dysfunction.ResultsThe average number of admissions stayed constant between the pre-COVID-19 (October 2018–February 2020) and COVID-19 periods (March 2020–February 2021). Patients transferred in from secondary centres had consistently higher severity scores during the COVID-19 period (UK Model for End-Stage Liver Disease 58 vs 54; p=0.007, Model for End-Stage Liver Disease-Sodium 22 vs 18; p=0.006, EF-CLIF Acute Decompensation (AD) score 55.0 vs 51.0; p=0.055). Of those admitted to the intensive care without acute-on-chronic liver failure, there was a significant increase in AD scores during the COVID-19 period (58 vs 48, p=0.009). In addition, there was a trend towards increased hospital readmission rates during the COVID-19 period (29.5% vs 21.5%, p=0.067). When censored at 30 days, early mortality postdischarge was significantly higher during the COVID-19 period (p<0.001) with a median time to death of 35 days compared with 62 days pre-COVID-19.DiscussionThis study provides a unique perspective on the impact that the global pandemic had on decompensated cirrhosis admissions. The findings of increased early mortality and readmissions, and higher AD scores on ICU admission, highlight the need to maintain resourcing for high-level hepatology care and follow-up, in spite of other disease pressures.
Men’s motivations, barriers to and aspirations for their families’ health in the first 1000 days in sub-Saharan Africa: a secondary qualitative analysis
Authors: Watson Daniella , Chatio Samuel , Barker Mary , Boua Palwende Romuald , Compaoré Adélaïde , Dalaba Maxwell , Erzse Agnes , Godfrey Keith , Hofman Karen , Kehoe Sarah , McGrath Nuala , Mukoma Gudani , Nonterah Engelbert A , Norris Shane A , Sorgho Hermann , Ward Kate A , Hardy-Johnson Polly 
Published: January 2023

IntroductionThe first 1000 days of life are a critical period of growth and development that have lasting implications for health, cognitive, educational and economic outcomes. In sub-Saharan Africa, gender and social norms are such that many men have little engagement with maternal and child health and nutrition during pregnancy and early childhood. This study explores how men perceive their role in three sites in sub-Saharan Africa.MethodsSecondary qualitative analysis of 10 focus group discussions with 76 men in Burkina Faso, Ghana and South Africa. Data were thematically analysed to explore men’s perceptions of maternal and child health and nutrition.ResultsMen considered themselves ‘providers’ and 'advisors' within their families, particularly of finances, food and medicines. They also indicated that this advice was out of care and concern for their families’ health. There were similarities in how the men perceive their role. Differences between men living in rural and urban settings included health priorities, the advice and the manner in which it was provided. Across all settings, men wanted to be more involved with maternal and child health and nutrition. Challenges to doing so included stigma and proscribed social gender roles.ConclusionMen want a greater engagement in improving maternal and child health and nutrition but felt that their ability to do so was limited by culture-specified gender roles, which are more focused on providing for and advising their families. Involving both men and women in intervention development alongside policymakers, health professionals and researchers is needed to improve maternal and child health and nutrition.
Determining the top research priorities in UK prehospital critical care: a modified Delphi study
Authors: Ramage Lisa , McLachlan Sarah , Williams Kristian 
Published: January 2023

BackgroundPrehospital critical care is a rapidly evolving field. There is a paucity of evidence relating to its practice, with limited progress in answering those research questions identified over a decade ago. It is vital that evidence gaps are identified and addressed. This study aimed to define the current research priorities in UK prehospital critical care.MethodsThis modified national Delphi study was coordinated by the Pre-HOspital Trainee Operated research Network and conducted in four rounds between October 2021 and April 2022. Rounds 1 and 2 were conducted online with clinicians involved in prehospital critical care delivery and non-clinical prehospital researchers. Rounds 3 and 4 were completed online by a subject matter expert (SME) panel.ResultsIn round 1, 78 participants submitted 394 research questions relating to prehospital critical care delivery in the UK. These were refined and categorised into 192 questions, which were scored for importance in round 2. Fifty questions were discussed and scored by the SME panel in round 3. Round 4 created a ranked top 20 list. The top research priority was ‘Which cardiac arrest patients should critical care teams be dispatched to; how do we identify these patients during the emergency call?’. Other priorities included dispatch optimisation, out-of-hospital medical cardiac arrest management, optimising resuscitation in haemorrhagic shock, improving traumatic brain injury outcomes and optimising management of traumatic cardiac arrest.ConclusionsThis modified Delphi study identified 20 research priorities where efforts should be concentrated to develop collaborative prehospital critical care research within the UK over the next 5 years.
Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases
Authors: Liu Qin , Zhang Tao , Chen Liqing , Zhou Xin , Zhang Xiaofei , Zheng Wenxin , Niu Shuang , Zhou Feng 
Published: January 2023

AimsTo stratify the risk of cervical precancers (high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS)) and cancers (squamous cell carcinoma (SCC) and adenocarcinoma) based on distinct high-risk human papillomavirus (hrHPV) genotypes as well as age groups among women with atypical squamous cells of undetermined significance (ASC-US) and hrHPV+results.MethodsIn total, 2292 cases of ASC-US/hrHPV+ with immediate follow-up biopsy results were included in the study for prevalence analysis.ResultsOverall, 12.2% women with ASC-US /hrHPV+ had HSIL+ while 0.22% had AIS+ lesions. The HPV-16+ group (31.6%) showed significantly higher prevalence of HSIL+ squamous lesions than other genotype groups (p<0.0001). The prevalence of SCC is significantly higher in HPV-16+ (1.8%) or HPV-18/45+ (1.1%) group than women in other genotype groups (0.1%) (p<0.0001). The HPV-18/45+ group (1.7%) showed significantly higher prevalence of AIS+ glandular lesions than other genotype groups (p=0.003). In addition, SCC prevalence was significantly higher in age over 50 group than that in age under 50 group (1.2% vs 0.2%, p=0.012).ConclusionWomen with ASC-US/hrHPV+ are at significant risk of cervical precancers and cancers; notably, HPV-16+ group has a higher risk of HSIL squamous lesions and SCC while HPV-18/45+ group has a higher risk of AIS+ glandular lesions. In addition, the older patient group (>50 years) has a significantly higher risk of SCC. Therefore, HPV genotyping as well as patient age need to be considered in the clinical management of patient.