bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of lung cancer in a real-world cohort via tumor-associated immune autoantibody and imaging combination
Authors: Liu Zhong , Zhang Feng , Jiang Jianwen , Zhao Chenzhao , Zhu Lu , Liu Chenbing , Li Nan , Qiu Lihong , Shen Chao , Sheng Di , Zeng Qiang 
Published: April 2023

BackgroundEfficient early detection methods for lung cancer can significantly decrease patient mortality. One promising approach is the use of tumor-associated autoantibodies (TAABs) as a diagnostic tool. In this study, the researchers aimed to evaluate the potential of seven TAABs in detecting lung cancer within a population undergoing routine health examinations. The results of this study could provide valuable insights into the utility of TAABs for lung cancer screening and diagnosis.MethodsIn this study, the serum concentrations of specific antibodies were measured using enzyme-linked immunosorbent assay (ELISA) in a cohort of 15,430 subjects. The efficacy of both a 7-TAAB panel and LDCT for lung cancer detection were evaluated through receiver operating characteristic (ROC) analyses, with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) being assessed and compared. These results could have significant implications for the development of improved screening methods for lung cancer.ResultsOver the 12-month observation period, 26 individuals were diagnosed with lung cancer. The 7-TAAB panel demonstrated promising sensitivity (61.5%) and a high degree of specificity (88.5%). The panel’s area under the receiver operating characteristic (ROC) curve was 0.8062, which was superior to that of any individual TAAB. In stage I patients, the sensitivity of the panel was 50%. In our cohort, there was no gender or age bias observed. This 7-TAAB panel showed a sensitivity of approximately 60% in detecting lung cancer, regardless of histological subtype or lesion size. Notably, ground-glass nodules had a higher diagnostic rate than solid nodules (83.3% vs. 36.4%, P = 0.021). The ROC analyses further revealed that the combination of LDCT with the 7-TAAB assay exhibited a significantly superior diagnostic efficacy than LDCT alone.ConclusionIn the context of the study, it was demonstrated that the 7-TAAB panel showed improved detective efficacy of LDCT, thus serving as an effective aid for the detection of lung cancer in real-world scenarios.
Jinhong decoction protects sepsis-associated acute lung injury by reducing intestinal bacterial translocation and improving gut microbial homeostasis
Authors: Bao Kaifan , Wang Meiling , Liu Li , Zhang Dongya , Jin Cuiyuan , Zhang Junfeng , Shi Liyun 
Published: April 2023

Background: Currently no specific treatments are available for sepsis and the associated syndromes including acute lung injury (ALI). Jinhong Decoction (JHD) is a traditional Chinese prescription, and it has been applied clinically as an efficient and safe treatment for sepsis, but the underlying mechanism remains unknown. The aim of the study was to explore the potential mechanisms of JHD ameliorating sepsis and concurrent ALI.Methods: The cecum ligation puncture (CLP)- induced murine sepsis model was established for determining the efficacy of JHD protecting CLP and ALI. The role of gut microbiota involved in the efficacy of JHD was evaluated by 16S rRNA sequencing and fecal microbiota transplantation (FMT). Translocation of intestinal Escherichia coli (E. coli) to lungs after CLP was verified by qPCR and in vivo-imaging. Intestinal permeability was analyzed by detecting FITC-dextran leakness. Junction proteins were evaluated by Western blotting and immunofluorescence.Results: JHD treatment remarkably increased survival rate of septic mice and alleviated sepsis-associated lung inflammation and injury. FMT suggested that the protective role for JHD was mediated through the regulation of gut microbiota. We further revealed that JHD administration partially restored the diversity and configuration of microbiome that was distorted by CLP operation. Of interest, the intestinal bacteria, E. coli particularly, was found to translocate into the lungs upon CLP via disrupting the intestinal mucosal barrier, leading to the inflammatory response and tissue damage in lungs. JHD impeded the migration and hence lung accumulation of intestinal E. coli, and thereby prevented severe ALI associated with sepsis. This effect is causatively related with the ability of JHD to restore intestinal barrier by up-regulating tight junctions.Conclusion: Our study unveils a mechanism whereby the migration of gut bacteria leads to sepsis-associated ALI, and we demonstrate the potential of JHD as an effective strategy to block this bacterial migration for treating sepsis and the associated immunopathology in the distal organs.
Zanthoxylum bungeanum seed oil inhibits tumorigenesis of human melanoma A375 by regulating CDC25A/CyclinB1/CDK1 signaling pathways in vitro and in vivo
Authors: Wang Wanting , Pang Wenwen , Yan Suying , Zheng Xiaoli , Han Qiurong , Yao Yao , Jin Leixin , Zhang Chunze 
Published: April 2023

Background:Zanthoxylum bungeanum seed oil (ZBSO) is extracted from the seeds of the traditional Chinese medicine Z. bungeanum Maxim, which has been shown to have anti-melanoma effects. However, the specific mechanisms are not illustrated adequately.Aims: To further investigate the mechanism by which ZBSO inhibits melanoma and to provide scientific evidence to support ZBSO as a potential melanoma therapeutic candidate.Methods: CCK-8 assays were used to detect the function of ZBSO on A375 cells. Based on transcriptomics analyses, Western blot analysis was applied to determine whether an association existed in ZBSO with the CDC25A/CyclinB1/CDK1 signaling pathway. In addition, RT-qPCR and immunohistochemistry analysis validated that ZBSO has the anti-melanoma effect in a nude mouse xenograft model of human melanoma. Then, 16S rRNA sequencing was used to detect the regulation of gut microbes.Results: Cellular assays revealed that ZBSO could inhibit A375 cell viability by regulating the cell cycle pathway. Further studies presented that ZBSO could constrain CDC25A/CyclinB1/CDK1 signaling pathway in vitro and in vivo models of melanoma. ZBSO did not produce toxicity in mice, and significantly reduced tumor volume in xenotransplants of A375 cells. Genome analysis indicated that ZBSO successfully altered specific gut microbes.Conclusion: ZBSO inhibited the growth of A375 cells by regulating CDC25A/cyclinB1/CDK1 signaling pathway both in vitro and in vivo, suggesting that ZBSO may be a novel potential therapeutic agent.
Antennal transcriptomic analysis of carboxylesterases and glutathione S-transferases associated with odorant degradation in the tea gray geometrid, Ectropis grisescens (Lepidoptera, Geometridae)
Authors: Zhang Fangmei , Chen Yijun , Zhao Xiaocen , Guo Shibao , Hong Feng , Zhi Yanan , Zhang Li , Zhou Zhou , Zhang Yunhui , Zhou Xuguo , Li Xiangrui 
Published: April 2023

Introduction: Carboxylesterases (CXEs) and glutathione S-transferases (GSTs) can terminate olfactory signals during chemosensation by rapid degradation of odorants in the vicinity of receptors. The tea grey geometrid, Ectropis grisescens (Lepidoptera, Geometridae), one of the most devastating insect herbivores of tea plants in China, relies heavily on plant volatiles to locate the host plants as well as the oviposition sites. However, CXEs and GSTs involved in signal termination and odorant clearance in E. grisescens remains unknown.Methods: In this study, identification and spatial expression profiles of CXEs and GSTs in this major tea pest were investigated by transcriptomics and qRT-PCR, respectively.Results: As a result, we identified 28 CXEs and 16 GSTs from female and male antennal transcriptomes. Phylogenetic analyses clustered these candidates into several clades, among which antennal CXEs, mitochondrial and cytosolic CXEs, and delta group GSTs contained genes commonly associated with odorants degradation. Spatial expression profiles showed that most CXEs (26) were expressed in antennae. In comparison, putative GSTs exhibited a diverse expression pattern across different tissues, with one GST expressed specifically in the male antennae.Disscussion: These combined results suggest that 12 CXEs (EgriCXE1, 2, 4, 6, 8, 18, 20-22, 24, 26, and 29) and 5 GSTs (EgriGST1 and EgriGST delta group) provide a major source of candidate genes for odorants degradation in E. grisescens.
Exploring the relationship between exposure to COVID-19 and donations during the COVID-19 pandemic: The mediating roles of emotions and risk perception
Authors: Bao Yun , Zhang Yan , Wang Junxiu 
Published: April 2023

ObjectivePublic emergency events like the COVID-19 pandemic are special occasions that need immediate massive funding from public donations. Thus, understanding the determinants of donation behaviors under public emergencies is important for both researchers and practitioners. This study investigated the effect of personal and local exposure to incidences of COVID-19 on donation behaviors. Specifically, we examined the mediating effects of risk perception and emotions on the relationship between exposure to COVID-19 and donation behaviors.MethodsThe data were from a survey distributed in China between March 20 and 30th, 2020. Participants’ donation choice at the end of the survey was used to measure their donation behaviors. Participants’ emotions, risk perception, and personal exposure were assessed in the questionnaire. Local exposure was the 30-day confirmed cases obtained from the National Health Commission of the People’s Republic of China. A total of 8,720 participants (Mean age = 28.91, 43.6% females) completed the online survey.ResultsBased on the results from the mediation analysis, we found that people with stronger positive and negative emotions, higher risk perception, and more personal exposure to COVID-19 were more likely to donate. Furthermore, the effects of both personal and local exposure on donations are mediated by risk perception and negative emotion. Both higher personal and local exposure led to stronger negative emotions and higher risk perception, which in turn led to more donation behaviors.DiscussionThis study extends our knowledge of donation behaviors during public emergencies. Our results suggest that policymakers and charity organizations should elicit stronger emotions and risk perception by exposing the severity of the disaster in advertisements to promote donations.
Perceived financial burden is indirectly linked to sexual well-being via quality of life among couples seeking medically assisted reproduction
Authors: Allsop David B. , Péloquin Katherine , Saxey Matthew T. , Rossi Meghan A. , Rosen Natalie O. 
Published: April 2023

IntroductionMedically assisted reproduction is a difficult treatment process for couples both financially and sexually. Yet, these two domains have not been examined together among couples seeking treatment, leaving couples and practitioners without guidance on how to address these domains together.MethodsIn line with Couples and Finance Theory, we tested the hypothesis that perceived financial burden and couple income would predict quality of life during medically assisted reproduction, which would then predict four domains of sexual well-being (i.e., sexual satisfaction, desire, distress, and frequency). We also examined if the results differed by treatment status—that is, between partners who were receiving treatment and those who were not. Cross-sectional data from 120 couples who had undergone medically assisted reproduction in the past six months were analyzed via structural equation modeling through an actor-partner interdependence mediation model.ResultsAn individual’s greater perceived financial burden predicted their own lower quality of life during medically assisted reproduction, which in turn predicted their lower sexual satisfaction, desire and distress, as well as their partner’s lower sexual satisfaction. Household income did not indirectly predict any sexual well-being domains, and results regarding treatment status were inconclusive.DiscussionClinicians can discuss with couples how perceived financial strain of medically assisted reproduction affects their quality of life and what ramifications that may have for their sexual well-being.
Validation of online mindfulness-enhanced course for stress reduction in teachers
Authors: Ye Qun , Huang Ying , Ge Xingcheng , Song Xiaolan 
Published: April 2023

BackgroundMindfulness-based interventions have gained popularity as a means of reducing stress and increasing resilience among the preclinical population. The present study aimed to investigate the effects of an online mindfulness-enhanced course on stress reduction in teachers, especially since online learning and teaching have been frequently applied to respond to emergencies such as COVID-19-relevant school suspension.MethodsThe study consisted of two phases. Phase 1 aimed to explore the relationship between teachers' perceived stress and mindfulness traits. In total of 6,252 teachers completed assessments of stress symptoms using the Chinese Perceived Stress Scale (CPSS) and occupational stress sources, as well as mindfulness using the Five Factor Mindfulness Questionnaire (FFMQ). Phase 2 aimed to examine the effectiveness of the online mindfulness-enhanced course. In total of 132 teachers were randomly assigned to either receive a 3-week online mindfulness course specifically designed for stress reduction and emotion regulation (N = 66) or a matched active control group (N = 66) and their pre-training and post-training self-reported states (e.g., perceived stress, mindfulness level, practice time) were measured.ResultsThe detection rate of Health Risk Stress (≥26 scores) was as high as 61.72%, and a negative association between the score of FFMQ and perceived stress level was found. Importantly, compared to the control group, the mindfulness training group showed a significant decrease in perceived stress and negative emotion, as well as an increase in understanding of the core mechanisms of mindfulness after training. Additionally, individual improvement in FFMQ scores was predicted by practice time.ConclusionsThe study showed a high percentage of teachers experiencing stress, and the data supported the reliability and validity of the brief online mindfulness-enhanced course designed to reduce stress and regulate emotion for frontline teachers.
COVID-19 Mass Vaccination Campaign: An International Comparison of Qatar With GCC Nations and Other Global Groups
Authors: Abdullahi Yasmin Ali Morad 
Published: April 2023

Objectives: Mass vaccination has been a key component in the effort to control the COVID-19 pandemic. Different countries have formulated their mass vaccination campaigns in different ways and with different priorities, with varying results. This study focuses on the case of Qatar in comparison with regional neighbors in the Gulf Cooperation Community (GCC) and with global benchmarks (G7 and OECD nations) in terms of the deployment of its mass vaccination program.Methods: Data on national vaccine administration and policy were obtained from Our World in Data and the Oxford COVID-19 Government Response Tracker for the period of 25 November 2020, when public vaccination first began to be implemented within the GCC, and June 2021, when Qatar’s mass vaccination campaign concluded. Factors compared cross-nationally included the total number of vaccine doses administered, doses administered per 100 population, the time taken to reach certain vaccination thresholds (5, 10, 25, 50, and 100 doses per 100 population), and policy regarding administration to specific priority groups. Cumulative vaccination rates were also compared graphically by date.Results: A descriptive comparison of vaccination rates illustrated that there were similar aggregate patterns among the GCC, G7, and OECD groups of countries, and that there was a great deal of heterogeneity in the patterns of vaccination between countries within each of these groups. The mass vaccination program in Qatar outpaced the aggregate GCC, G7, and OECD groups.Conclusion: There were large between-country differences in the speed of mass vaccination progress which did not appear to be directly explained by national wealth. It is suggested that administrative and program management factors could account for some of these differences.
Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats
Authors: Muzaffar Humaira , Qamar Iqra , Bashir Muhammad , Jabeen Farhat , Irfan Shahzad , Anwar Haseeb 
Published: April 2023

Gymnema sylvestre is traditionally used as an herbal remedy for diabetes. The effect of Gymnema sylvestre supplementation on beta cell and hepatic activity was explored in an alloxan-induced hyperglycemic adult rat. Animals were made hyperglycemic via a single inj. (i.p) of Alloxan. Gymnema sylvestre was supplemented in diet @250 mg/kg and 500 mg/kg b.w. Animals were sacrificed, and blood and tissues (pancreas and liver) were collected for biochemical, expression, and histological analysis. Gymnema sylvestre significantly reduced blood glucose levels with a subsequent increase in plasma insulin levels in a dosage-dependent manner. Total oxidant status (TOS), malondialdehyde, LDL, VLDL, ALT, AST, triglyceride, total cholesterol, and total protein levels were reduced significantly. Significantly raised paraoxonase, arylesterase, albumin, and HDL levels were also observed in Gymnema sylvestre treated hyperglycemic rats. Increased mRNA expression of Ins-1, Ins-2, Gck, Pdx1, Mafa, and Pax6 was observed, while decreased expression of Cat, Sod1, Nrf2, and NF-kB was observed in the pancreas. However, increased mRNA expression of Gck, Irs1, SREBP1c, and Foxk1 and decreased expression of Irs2, ChREBP, Foxo1, and FoxA2 were observed in the liver. The current study indicates the potent effect of Gymnema sylvestre on the transcription modulation of the insulin gene in the alloxan-induced hyperglycemic rat model. Enhanced plasma insulin levels further help to improve hyperglycemia-induced dyslipidemia through transcriptional modulation of hepatocytes.
Le fantôme de la mère morte, un exemple de problématique de deuil à l'adolescence
Authors: Couchard Françoise 
Published: April 2023

Françoise Couchard, El fantasma de la madre muerta, un ejemplo de la problemática de duelo en la adolescencia.
Proponemos aquí algunas hipótesis sobre la problemática del duelo cuando ella sobreviene en la adolescencia. A partir de la observación de una construction fantasmática : la del fantasma de la madré muerta en una jovencita, estudiamos varios puntos. El impacto de esta construccción sobre la fijación edípica, el "triunfo del yo" en el trabajo de duelo con vacilación entre una idealisación de la madre muerta y la expresión de reproches para con ella en los sentimientos de descuido, de abandono, reactivando aquéllos del joven niño. Analizamos la proximidad entre la construccción del "fantasma" y el fenómeno del "Doble". Insistimos sobre el peso de los secretos que unen Eros y Tánatos que dividen a la madré y a la hija y que se encontrarn definitivamente encubridos con la muette de la primera.

Palabras-clave : Adolescencia, Trabajo de duelo, Idealisación del "objeto perdido", Identificatión madre/hija, Fantasma de la madre muerta.
De la douleur physique chronique : étude comparative des positions de la médecine et de psychologie clinique
Authors: Santiago Delefosse Marie 
Published: April 2023

Marie Santiago Delefosse, Chronic physical pain : A comparative study of the positions held in médecine and in psychological clinical practice.
Basing his work on the confrontation between the medical and psychoanalytical positions relative to physical pain, the author demonstrates the incompatibility of the two positions, and makes a case for the "ethics of intervention" of a clinical psychologist in Pain Clinics. His institutional function and role must not be confused with his role in the framework of a psychoanalytical cure. Each time the clinical psychologist finds himself consulted because of "the patient's transfer to the medical realm" he runs the risk of being seen as a "supplement" and can quickly become a complementary instrument used by médecine in its effort to have all possible assets on its side. The ethics of the psychologist should be to respect the patient's desire and to accept his refusal to know. Beginning with this respect which avoids forcible interpretations and taking as much time as necessary, including the time of verbalized accompaniment, it will be possible for the psychologist to participate in the construction of a space which takes the psychic dimension into account.

Key words : Chronic physical pain, Clinical psychology, Psychoanalysis, Médecine, Pain Clinics, Homo dolorus.
La névrose hier et aujourd'hui. Apports du Rorschach
Authors: Boekholt Monika , Bailly-Sallin Marie-Josée , Duplant Nicole , Jeammet Nicole , Martin Michèle , Monin Estelle , Poggionovo Marie-Paule 
Published: April 2023

Monika Boekholt, Marie-Josée Bailly-Sallin, Nicole Duplant, Nicole Jeammet, Michèle Martin, Estelle Monin, Marie-Paule Poggionovo, La neurosis ayer y hoy. Aportes del Rorschach.
23 protocolos de Rorschach considerados como neuróticus en 1970, han sido revisados a la luz de trabajos contemporáneos integrando los funcionamientos límites y narcisistas. Así como los criterios antiguos que conciernen a la neurosis obsesiva se mantienen estables, del mismo modo, la cuestión de la histeria contribuye a alimentar numerosas discusiones ; la cuestión central reside en el grado de tolerancia otorgado a las manisfestaciones regresivas.

Palabras-clave : Neurosis, Funcionamientos Iímites, Diagnóstico diferencial, Clínica proyectiva, Rorschach, 1970-1997.
Hystérie et fonctionnement limite : étude comparative de deux protocoles de Rorschach
Authors: Bailly-Sallin Marie-Josée , Duplant Nicole , Martin Michèle 
Published: April 2023

Marie-José Bailly-Salin, Nicole Duplant, Michèle Martin, Histeria y funcionamiento límite : estudio comparativo de dos protocolos de Rorschach.
Los autores presentan un estudio comparativo entre dos protocolos de Rorschach, considerados en los años 70 como neuróticos. La metodología consiste en un estudio lámina por lámina, respuesta por respuesta, con el fin de poner en perspectiva, desde un punto de vista psicoanalítico, los elementos actuates déterminantes de un diagnóstico diferencial entre funcionamiento histérico y funcionamiento límite.

Palabras-clave : Histeria, Funcionamiento limite, Rorschach, Materno, Femenino.
La dépression postnatale dans les organisations névrotiques hystériques : approche clinique et projective
Authors: Tychey (de) Claude , Touvenot Valérie 
Published: April 2023

C. de Tychey, V. Touvenot, Postnatal Depression in Hysterical-Neurotic Organisations : A Clinical and Projective Approach.
The authors present the psychodynamic conflicts related to postnatal depressions in hysterical neurotic personality organizations.They illustrate their point of view with the help of a clinical case as it is viewed by means of the Rorschach test using a classical and associative procedure.

Keywords : Postnatal depression, Psychodynamic theory, Clinical approach, Rorschach test, Hysteria