bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virologic Nonsuppression Among Patients With HIV Newly Diagnosed With Cancer at Uganda Cancer Institute: A Cross-Sectional Study
Authors: Kauma Geraldine , Ddungu Henry , Ssewanyana Isaac , Nyesiga Sharon , Bogere Naghib , Namulema-Diiro Teddy , Byakika-Kibwika Pauline , Namukwaya Elizabeth , Kizza Harriet Mayanja 
Published: April 2023

PURPOSE AIDS-related mortality declined markedly since the introduction of antiretroviral therapy (ART); however, cancer mortality in Africa was higher than its incidence in 2020. People living with HIV (PLWHIV) are at an increased risk of malignancy and death from malignancy compared with the general population. In Uganda, AIDS-defining malignancies (ADMs), including cervical cancer, Kaposi sarcoma, and non-Hodgkin lymphoma, are among the commonest malignancies. Virologic nonsuppression has been identified as an important predictor of mortality among PLWHIV diagnosed with cancer. This study aimed to determine the prevalence and to identify factors associated with virologic nonsuppression among PLWHIV newly diagnosed with cancer. METHODS This was a cross-sectional study that was carried out between December 2018 and April 2019 at the Uganda Cancer Institute. PLWHIV who had been on ART for at least 6 months and were newly diagnosed with cancer were enrolled. RESULTS A total of 167 participants were enrolled. Cervical cancer was the commonest ADM (n = 45; 50.6%) of all ADMs, while esophageal and breast cancers were the commonest non-ADMs, accounting for 17.5% (n = 14) each of all non-ADMs. The prevalence of virologic nonsuppression was 15%. Having Kaposi sarcoma (odds ratio [OR], 8.15; P = .003), being poorly adherent to ART (OR, 4.1; P = .045), and being on second-line ART (OR, 5.68; P = .011) were associated with virologic nonsuppression. CONCLUSION The prevalence of virologic nonsuppression is high among patients with HIV newly diagnosed with cancer. These findings emphasize the need for strengthening of adherence strategies, optimizing ART regimens, and prioritization of viral load testing among PLWHIV with newly diagnosed malignancy.
Molecular Photoinduced Charge Separation: Fundamentals and Application
Authors: Imahori Hiroshi 
Published: April 2023

Abstract
We have designed and synthesized a number of donor-acceptor linked systems to elucidate the science of photoinduced charge separation. In particular, porphyrin-fullerene and polymer-fullerene linked molecules have been found to be very useful as model systems for addressing issues in excited-state generation, charge separation, and charge dissociation. We have also proposed a new concept, “dynamic exciton” to establish new comprehensive photochemistry dealing with manipulation of locally excited state, charge-transfer state, and charge-separated state involving mutual transformation. Simultaneously, it is pivotal to adopt time-dependent dynamic effects on electron and spin behaviors entangled with movement of atomic nuclei (i.e., vibration, rotation, and fluctuation) and their collective motion into molecular donor-acceptor systems. Versatile dyes for dye-sensitized solar cells as well as donor/acceptor molecules for bulk heterojunction organic solar cells have also been tailored toward better understanding the underlying mechanism as well as improving their photovoltaic performances. Meanwhile, giant dipole moment produced from donor-acceptor linked molecules by light has been successfully utilized to regulate the membrane potential of living biological cells. This is the first example of the use of charge-separated state in optogenetics and is promising as neuronal therapy by light.
Research’s policies on health: fundamental texts of the European Union and Greece
Authors: Masoura Photini , Skitsou Alexandra , Laizinou Alexandra-Nektaria , Charalambous George 
Published: April 2023

The research on health has to offer new data which are based on empirical facts. That fact doesn’t make the research immoral or without limits. The purpose of this study is the survey of the existing knowledge about the scientific research on the health’s field and the promotion of the major institutional legislation that set the boundaries of the research as well as of the problems that arise from it. We noticed a lack of published articles about the European policies around research on health. We present new data and we ended up to conclusions which for the first time are been published in this domain. Main aim is to expand the policies that the European Union follows on the field of health’s scientific research that come up through studying relevant legislation.
We studied the main international and European institutional and legislative articles as well as Greek domestic law through Google scholar and the website (of) World Medical Association , through the Greece’s National printing house , the Greek parliament, the European council and the European’s Commission’s site that sets the boundaries of the scientific study on the health’s field and we proceed on a historical flashback so we would be able to explain the need of the creation of these legislative texts. The research took place in December of 2017 and it got repeated in March-April of 2021. The medical research was originally aiming the improvement of the human life. In the legislative texts which try to put restrictions in the ways of the scientific research’s conduction, there are some gaps. New forms of scientific research create some questions considering the subject’s safety. In conclusion several concerns came up which demand to be answered with insight and creative thought.
Case Report: Management strategy of rare case first-generation antipsychotic drug induced neglected femoral neck fracture in schizophrenia patients
Authors: Harahap Rudiansyah , Meisari Putri Anugerah , Tjandra Kevin Christian 
Published: April 2023

Background: The early onset of femoral neck fracture is commonly treated by bone grafting surgery. However rare cases of neglected femoral neck fractures in schizophrenic patients need to be treated by arthroplasty because of the rapid destruction of the femoral head within the acetabulum. Case presentation: We report a rare unique case of first-generation antipsychotic drug-induced neglected femoral neck fracture in a 41-year-old man presenting after a month complaining of not being able to walk due to falling in a ditch. X-ray examination findings revealed total destruction of the femoral head within the acetabulum with no acetabulum dysplasia detected. Ordinarily, it should be treated with a bone grafting procedure since no dysplasia was detected and it was an early onset case. However, arthroplasty was chosen because the femoral head was destructed. Three months post-surgery x-ray shows the acetabulum dysplasia and lytic lesion that confirm drug-induced bone destruction by the first-generation antipsychotic drug. Conclusions: We suggest that even though rare, first-generation antipsychotic drugs neglected femoral neck fractures in schizophrenia patients can be successfully treated by arthroplasty supported by the patient’s compliance. Bone mineral density (BMD) test is also suggested to monitor the bone density of schizophrenia patients.
Blood pressure and 10-year all-cause mortality: Findings from the PERU MIGRANT Study
Authors: Hidalgo-Benites Aida , Senosain-Leon Valeria , Carrillo-Larco Rodrigo M. , Ruiz-Alejos Andrea , Gilman Robert H. , Smeeth Liam , Miranda J. Jaime , Bernabé-Ortiz Antonio 
Published: April 2023

Background The long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC/AHA) 2017 blood pressure guidelines. Methods Data of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated. Results A total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%–18.4%) to 31.3% (95% CI 28.4%–34.3%), using the JNC-7 and ACC/AHA 2017 definitions, respectively. Sixty-three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4–4.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.5-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC/AHA 2017 for stage 1 and stage 2 hypertension. Conclusions Blood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of the health system to adequately handle a large proportion of new patients.
Developing and testing a protocol using a common data model for federated collection and analysis of national perinatal health indicators in Europe
Authors: Zeitlin Jennifer , Philibert Marianne , Estupiñán-Romero Francisco , Loghi Marzia , Sakkeus Luule , Draušnik Željka , Alcaide Adela Recio , Durox Mélanie , Cap Jan , Dimnjakovic Jelena , Misins Janis , Bernal Delgado Enrique , Thissen Martin , Gissler Mika ,   Euro-Peristat Research Group
Published: April 2023

Context: International comparisons of the health of mothers and babies provide essential benchmarks for guiding health practice and policy, but statistics are not routinely compiled in a comparable way. These data are especially critical during health emergencies, such as the coronavirus disease (COVID-19) pandemic. The Population Health Information Research Infrastructure (PHIRI) project aimed to promote the exchange of population data in Europe and included a Use Case on perinatal health. Objective: To develop and test a protocol for federated analysis of population birth data in Europe. Methods: The Euro-Peristat network with participants from 31 countries developed a Common Data Model (CDM) and R scripts to exchange and analyse aggregated data on perinatal indicators. Building on recommended Euro-Peristat indicators, complemented by a three-round consensus process, the network specified variables for a CDM and common outputs. The protocol was tested using routine birth data for 2015 to 2020; a survey was conducted assessing data provider experiences and opinions. Results: The CDM included 17 core data items for the testing phase and 18 for a future expanded phase. 28 countries and the four UK nations created individual person-level databases and ran R scripts to produce anonymous aggregate tables. Seven had all core items, 17 had 13-16, while eight had ≤12. Limitations were not having all items in the same database, required for this protocol. Infant death and mode of birth were most frequently missing. Countries took from under a day to several weeks to set up the CDM, after which the protocol was easy and quick to use. Conclusion: This open-source protocol enables rapid production and analysis of perinatal indicators and constitutes a roadmap for a sustainable European information system. It also provides minimum standards for improving national data systems and can be used in other countries to facilitate comparison of perinatal indicators.
Adjustable Distributionally Robust Optimization with Infinitely Constrained Ambiguity Sets
Authors: Ruan Haolin , Chen Zhi , Ho Chin Pang 
Published: April 2023

We study adjustable distributionally robust optimization problems, where their ambiguity sets can potentially encompass an infinite number of expectation constraints. Although such ambiguity sets have great modeling flexibility in characterizing uncertain probability distributions, the corresponding adjustable problems remain computationally intractable and challenging. To overcome this issue, we propose a greedy improvement procedure that consists of solving, via the (extended) linear decision rule approximation, a sequence of tractable subproblems—each of which considers a relaxed and finitely constrained ambiguity set that can be iteratively tightened to the infinitely constrained one. Through three numerical studies of adjustable distributionally robust optimization models, we show that our approach can yield improved solutions in a systematic way for both two-stage and multistage problems. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: Financial support by the Early Career Scheme from the Hong Kong Research Grants Council [Project No. CityU 21502820], the CityU Start-Up Grant [Project No. 9610481], the CityU Strategic Research Grant [Project No. 7005688], the National Natural Science Foundation of China [Project No. 72032005], and Chow Sang Sang Group Research Fund sponsored by Chow Sang Sang Holdings International Limited [Project No. 9229076] is gratefully acknowledged. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2021.0181 ), as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0181 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Application of the multivariate and univariate analyses to estimate the feed efficiency in beef cattle
Authors: Oliveira Tadeu Silva de , Silva Ismael Nacarati , Aniceto Elon Souza , Júnior José Ribeiro Meirelles 
Published: April 2023

This study aimed to compare the univariate analyses (relationship between dry matter intake (DMI) and average daily gain (ADG), Kleiber ratio, and residual feed intake) and multivariate analysis (bionutritional index [BNI]) to determine feed efficiency. Were used a total of 160 cattle (individual data) and the analyzed variables were dry matter intake, weight gain, and body weight of the animals. We used five methods to evaluate feed efficiency, the BNI, FE, corrected feeding efficiency (corFE), Kleiber ratio (KR), and residual feed intake (RFI). Study 1 demonstrated that only the FE (p=0.0472) was significant, although the FE after the transformation of Box-Cox (corFE) (p=0.0642) showed a statistical trend. In studies 2, 3, and 5, we observed that BNI was the best biological efficiency indicator. In the study 4, we observed that the best indicators were FE (0.110; p=0.0281), corFE (0.380; p=0.0429), and RFI (0.465; p=0.0340) for the genders. However, corFE decreased the coefficient of variation in all studies. In conclusion, the use of the Box-Cox transformation is as efficient as the multivariate analysis in discriminating experimental groups (genetic groups, different levels of concentrate in the diet, and genders) concerning the other univariate analyzes.
Popular Islamist Authoritative Parenting: A Contest of Identity in Islamic Education for Early Childhood
Authors: Mustakim Bagus , Hasan Noorhaidi , Lessy Zulkipli 
Published: April 2023

Purpose - This article aims to explain the values ​​of Islamism that are reproduced in animated videos of children, the religious style that is developed, and the identity of parenting that is constructed and contested.
Methods - The study was conducted qualitatively with a phenomenological approach, namely by constructing understanding, motivation, and parenting practices reproduced in animated videos. Data were collected through video documentation and analyzed by discourse analysis.
Findings - It is concluded that: 1)the Islamism reproduced in the animation of Nussa leads to the development of Salafism values ​​in early childhood care. 2) This development uses the Salafi religious style as a parenting style and practice which I call the popular Islamist authoritative parenting model. 3) This parenting model is encouraged to gain symbolic power in order to win authority in the field of early childhood care.
Research limitation - The research was conducted on 30 animated videos of Nussa which were published in the first season.
Originality/Value - The findings of this study provide an overview of popular Islamist authoritative parenting that is promoted as a model of Islamic early childhood care.
Developing Religious Moderation in Indonesian Islamic Schools Through the Implementation of the Values of Islām Wasaṭiyyah
Authors: Muqowim Muqowim , Sibawaihi Sibawaihi , Alsulami Naif Daifullah 
Published: April 2023

Purpose – This study aims at identifying the importance of religious moderation through understanding and practicing the values of Islām wasaṭiyyah in the learning process in Indonesian madrasah.
Design/methods/approach – Using a historical approach, this qualitative study investigates the practices of the values of Islām wasaṭiyyah by medieval Muslim figures ​​and explores indicators of success in learning based on those values ​​in madrasah. Data were collected through document analysis.
Findings – The authors found that of the seven values selected—tolerance, egalitarian, dynamic and innovative, reform, taking the path middle, balance, and prioritizing the priority—the figures practiced them simultaneously. The indicators of success in learning are students, teachers, and parents have an awareness of the importance of the values ​​of wasaṭiyyah; students become the center of pedagogy reflecting those values; students and teachers act independently in implementing those values; students and teachers are involved in collaboration in developing those values; and there is transformation to the better one due to the inculcation of those values.
Research implications/limitations – Because the study applies a historical approach, it uses only documents as its data source. Future studies can use interviews and observations so that the results are more trustworthy.
Originality/value – The findings of the study provide an overview of the extent to which the values of Islām wasaṭiyyah have been practiced in Islamic schools in Indonesia.
Developing a Google Form-based Instrument for Measuring the Spiritual Attitude of the Students Class XI
Authors: Eva Farida , Widihastuti Widihastuti , Istiyono Edi 
Published: April 2023

Purpose – This study aims to construct an instrument for assessing the spiritual attitudes of moral subjects and how much the contribution of these spiritual attitudes can be applied in everyday life.
Design/methods/approach – The research approach used by RnD (Research and Development) with the ADDIE (Analysis, Design, Development, Implementation and Evaluation) model. The subjects of this study were students of class XI. Data collection techniques use the Likert scale.
Findings – The instrument was analyzed using Exploratory Factor Analysis (EFA); in the assessment of spiritual attitudes, there were four factors/dimensions, but the per-factor instrument variables did not correspond to the initial dimensions (obedience, thanksgiving, praying, and tasamuh) with the average value of the loading factor of each factor namely F1 = 0.650, F2 = 0.615, F3 = 0.578 and F4 = 0.774. In contrast, the instrument reliability test obtained a value of 0.705 with a high instrument category. The analysis results produce the findings by making new factors, namely tasamuh, gratitude, worship, and aqidah.
Research implications/limitation – This spiritual attitude assessment can be used in all Madrasah Aliyah in Indonesia. However, due to the limitations of researchers in distributing questionnaires, this research was only conducted in Sintang Regency.
Originality/value – Further research is expected to construct an assessment of the spiritual attitudes of students in terms of more specific aspects of learning and daily life.
Utilizing Item Response Theory Approach for Calibrating Items in the Final Assessment of Islamic Cultural History Subject
Authors: Prihatin Rani Putri , Fatonah Siti , Ahmad Iqbal Faza 
Published: April 2023

Purpose –The aim of this exploratory descriptive study with a IRT approach is to evaluate the quality of items used in the final assessment of 10th grade Islamic cultural history subject at Madrasah Aliyah Negeri (MAN) 2 Bantul Yogyakarta.
Design/methods/approach–Data was collected through documentation of student responses at the end of the year assessment. Student response data were analyzed using the item response theory approach.
Findings – Based on the analysis of 25 questions on the Islamic Cultural History subject at MAN 2 Bantul, the study concludes that the instrument fits the 1 PL model (Logistics parameter), as indicated by the results of the model fit test. The parameter analysis of item difficulty level with the 1 PL model reveals that 7 items fall under the very easy category, 5 items under the easy category, 9 items under the medium category, and 4 items under the very difficult category. Notably, none of the items fall under the difficult category in this 1 PL model.
Research implications/limitations –The findings on the distribution of item difficulty levels could guide educators in revising and improving the quality of assessment tools, ensuring that the questions are well-balanced and challenging enough to effectively evaluate students' knowledge and skills. Moreover, the absence of items falling under the difficult category in the 1 PL model suggests a need for more rigorous and challenging items to enhance the validity and reliability of the assessment instrument.
Originality/value–The research value of this study lies in its contribution to the development of a valid and reliable assessment tool in the field of Islamic cultural history subject.
Positive Parenting from the Perspective of Luqman Al-Hakim
Authors: Rahmatullah Azam Syukur , Marpuah Siti 
Published: April 2023

Purpose–This study aims to exlpore more deeply the positive parenting based on QS Luqman verses 13-19, which discusses parenting by Luqman and is made an exemplary role model of "positive parenting" by Allah SWT. It is so that parenting is created oriented towards the Qur'an and does not deviate from the "standard rules" of parenting based on the Qur'an. Hence, it is expected that there will be products for raising children who are illahiyah pious and socially pious.
Design/methods/approach–This qualitative research with a content analysis approach explored and discussed the contents of written or printed information in the mass media more deeply. In this case, the researcher searched for articles closely related to parenting issues and about Luqman al-Hakim through Google Scholar.
Findings– This study highlights several of Luqman's parenting characteristics that made him intelligent in raising children, i.e., being firm in matters of faith in QS Luqman verses 13 and 17, gentle in speaking in QS Luqman verses 13, 16, and 17, attached to the child (intimacy) in QS Luqman verses 13, 16, 17, 18, and 19, and constantly reminding children to do good in QS Luqman verses 13, 16, 17, 18, and 19.
Research implications/limitations–Some of Luqman's parenting styles successfully explored based on QS Luqman, including parenting based on being valued, parenting based on understanding and enlightening, and parenting based on self-control.
Originality/value–Research with the theme of positive parenting originated from the verses of the Qur'an about Luqman al-Hakim has not been studied much. Generally, studies only revolve around parenting, ways of educating, and Luqman Hakim's parenting concept. Nevertheless, studies related to positive parenting have not been found. Therefore, research is pure, rich in novelty, and has a positive scientific contribution.