bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tactical Opposition: Obstructing Loss and Damage Finance in the United Nations Climate Negotiations
Authors: Falzon Danielle , Shaia Fred , Roberts J. Timmons , Hossain Md. Fahad , Robinson Stacy-ann , Khan Mizan R. , Ciplet David 
Published: July 2023

Abstract
In 1991, in meetings constructing the United Nations Framework Convention on Climate Change, the small island state of Vanuatu introduced a proposal requiring wealthy countries to pay for damages related to sea level rise. More than thirty years later, countries finally agreed to establish a financing mechanism for loss and damage associated with climate change. Scholars have observed the slow progress on loss and damage finance, but what tactics did countries use to obstruct negotiations? We answer this question using data from primary and secondary sources, observations at negotiations, and key informant interviews. Our analysis details four periods of obstruction and outlines a typology of fourteen tactics countries have used to delay progress. These tactics limited the issue’s scope, reduced transparency, manipulated language, and advanced nontransformative solutions. These findings contribute to the study of obstructionism in climate governance and can help loss and damage advocates better anticipate and respond to obstruction.
Functional Organization of Auditory and Reward Systems in Aging
Authors: Belden Alexander , Quinci Milena Aiello , Geddes Maiya , Donovan Nancy J. , Hanser Suzanne B. , Loui Psyche 
Published: July 2023

Abstract
The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (n = 24) and older (n = 24) adults, using whole-brain regression, seed-based connectivity, and ROI–ROI connectivity analyses. As expected, activity and connectivity of auditory and reward networks scaled with liking during music listening in both groups. Younger adults show higher within-network connectivity of auditory and reward regions as compared with older adults, both at rest and during music listening, but this age-related difference at rest was reduced during music listening, especially in individuals who self-report high musical reward. Furthermore, younger adults showed higher functional connectivity between auditory network and medial prefrontal cortex that was specific to music listening, whereas older adults showed a more globally diffuse pattern of connectivity, including higher connectivity between auditory regions and bilateral lingual and inferior frontal gyri. Finally, connectivity between auditory and reward regions was higher when listening to music selected by the participant. These results highlight the roles of aging and reward sensitivity on auditory and reward networks. Results may inform the design of music-based interventions for older adults and improve our understanding of functional network dynamics of the brain at rest and during a cognitively engaging task.
Alpha Oscillations Create the Illusion of Time
Authors: Wutz Andreas 
Published: July 2023

Abstract
Recent neuroscience experiments have brought inconsistent findings to light about the influence of neural activity in the alpha-frequency band (at ≈10 Hz) on the temporal dynamics of visual perception. Whereas strong alpha effects were found when perception was more based on endogenous factors, there were null-effects for alpha when perception relied more on objective physical parameters. In this Perspective, I open up a new view on neural alpha activity that resolves some important aspects of this controversy by interpreting alpha not as temporal processing of sensory inputs per se but above all as the observer's internal processing dynamics, their so-called perception sets. Perception sets reflect internally stored knowledge for how to organize and build up perceptual processes. They result from previous sensory experiences, are under top–down control to support goal-directed behavior, and root in pre-established neural networks that communicate through alpha frequency channels. I present three example cases from the recent neuroscience literature that show an influence of alpha-driven perception sets on the observer's visual-temporal resolution, object processing, and the processing of behaviorally relevant image content. Because alpha-driven perception sets can structure perception from its high-level aspects, like categories, down to its basic building blocks, like objects and time samples, they may have a fundamental impact on our conscious experience of the sensory world, including our perception of time itself.
Feature-based Attentional Amplitude Modulations of the Steady-state Visual Evoked Potentials Reflect Blood Oxygen Level Dependent Changes in Feature-sensitive Visual Areas
Authors: Boylan Maeve R. , Panitz Christian , Tebbe Anna-Lena , Vieweg Paula , Forschack Norman , Müller Matthias M. , Keil Andreas 
Published: July 2023

Abstract
Recent EEG studies have investigated basic principles of feature-based attention by means of frequency-tagged random dot kinematograms in which different colors are simultaneously presented at different temporal frequencies to elicit steady-state visual evoked potentials (SSVEPs). These experiments consistently showed global facilitation of the to-be-attended random dot kinematogram—a basic principle of feature-based attention. SSVEP source estimation suggested that posterior visual cortex from V1 to area hMT+/V5 is broadly activated by frequency-tagged stimuli. What is presently unknown is whether the feature-based attentional facilitation of SSVEPs is a rather unspecific neural response including all visual areas that follow the “on/off,” or whether SSVEP feature-based amplitude enhancements are driven by activity in visual areas most sensitive to a specific feature, such as V4v in the case of color. Here, we leverage multimodal SSVEP-fMRI recordings in human participants and a multidimensional feature-based attention paradigm to investigate this question. Attending to shape produced significantly greater SSVEP-BOLD covariation in primary visual cortex compared with color. SSVEP-BOLD covariation during color selection increased along the visual hierarchy, with greatest values in areas V3 and V4. Importantly, in area hMT+/V5, we found no differences between shape and color selection. Results suggest that SSVEP amplitude enhancements in feature-based attention is not an unspecific enhancement of neural activity in all visual areas following the “on/off.” These findings open new avenues to investigating neural dynamics of competitive interactions in specific visual areas sensitive to a certain feature in a more economical way and better temporal resolution compared with fMRI.
Ecstatic or Mystical Experience through Epilepsy
Authors: Picard Fabienne 
Published: July 2023

Abstract
Ecstatic epilepsy is a rare form of focal epilepsy, so named because the seizures' first symptoms consist of an ecstatic/mystical experience, including feelings of increased self-awareness, mental clarity, and “unity with everything that exists,” accompanied by a sense of bliss and physical well-being. In this perspective article, we first describe the phenomenology of ecstatic seizures, address their historical context, and describe the primary brain structure involved in the genesis of these peculiar epileptic seizures, the anterior insula. In the second part of the article, we move onto the possible neurocognitive underpinnings of ecstatic seizures. We first remind the reader of the insula's role in interoceptive processing and consciously experienced feelings, contextualized by the theory of predictive coding. This leads us to hypothesize that temporary disruptions to activity in the anterior insula could interrupt the generation of interoceptive prediction errors, and cause one to experience the absence of uncertainty, and thereby, a sense of bliss. The absence of interoceptive prediction errors would in fact mimic perfect prediction of the body's physiological state. This sudden clarity of bodily perception could explain the ecstatic quality of the experience, as the interoceptive system forms the basis for unified conscious experience. Our alternative hypothesis is that the anterior insula plays an overarching role in the processing of surprise and that the dysfunction caused by the epileptic discharge could interrupt any surprise exceeding expectations, resulting in a sense of complete control and oneness with the environment.
Graph-Regularized Tensor Regression: A Domain-Aware Framework for Interpretable Modeling of Multiway Data on Graphs
Authors: Xu Yao Lei , Konstantinidis Kriton , Mandic Danilo P. 
Published: July 2023

Abstract
Modern data analytics applications are increasingly characterized by exceedingly large and multidimensional data sources. This represents a challenge for traditional machine learning models, as the number of model parameters needed to process such data grows exponentially with the data dimensions, an effect known as the curse of dimensionality. Recently, tensor decomposition (TD) techniques have shown promising results in reducing the computational costs associated with large-dimensional models while achieving comparable performance. However, such tensor models are often unable to incorporate the underlying domain knowledge when compressing high-dimensional models. To this end, we introduce a novel graph-regularized tensor regression (GRTR) framework, whereby domain knowledge about intramodal relations is incorporated into the model in the form of a graph Laplacian matrix. This is then used as a regularization tool to promote a physically meaningful structure within the model parameters. By virtue of tensor algebra, the proposed framework is shown to be fully interpretable, both coefficient-wise and dimension-wise. The GRTR model is validated in a multiway regression setting and compared against competing models and is shown to achieve improved performance at reduced computational costs. Detailed visualizations are provided to help readers gain an intuitive understanding of the employed tensor operations.
Ǧuḥā/Giufà: a Cunning Fool Bridge of Dialogue between East and West
Authors: Corrao Francesca Maria 
Published: July 2023

Abstract
Ǧuḥā/Giufà is a foolish rogue whose anecdotes are spread in the Mediterranean region; this area is characterized by different religious culture and the anecdotes show that these convey important shared values. Recent studies proved that a good number of these stories have far Eastern origins demonstrating that human community has important values to educate to a more harmonious global society. The study gives some information on the analysis of the hero from Western and Eastern perspectives and indicates some of the stories of far Eastern origins spread in the Mediterranean.
Corrections for Geostationary Cloud Liquid Water Path Using Microwave Imagery
Authors: Smalley Kevin M. , Lebsock Matthew D. 
Published: July 2023

Abstract
Geostationary observations provide measurements of the cloud liquid water path (LWP), permitting continuous observation of cloud evolution throughout the daylit portion of the diurnal cycle. Relative to LWP derived from microwave imagery, these observations have biases related to scattering geometry, which systematically varies throughout the day. Therefore, we have developed a set of bias corrections using microwave LWP for the Geostationary Operational Environmental Satellite-16 and -17 (GOES-16 and GOES-17) observations of LWP derived from retrieved cloud-optical properties. The bias corrections are defined based on scattering geometry (solar zenith, sensor zenith, and relative azimuth) and low cloud fraction. We demonstrate that over the low-cloud regions of the northeast and southeast Pacific, these bias corrections drastically improve the characteristics of the retrieved LWP, including its regional distribution, diurnal variation, and evolution along short-time-scale Lagrangian trajectories.

Significance Statement
Large uncertainty exists in cloud liquid water path derived from geostationary observations, which is caused by changes in the scattering geometry of sunlight throughout the day. This complicates the usefulness of geostationary satellites to analyze the time evolution of clouds using geostationary data. Therefore, microwave imagery observations of liquid water path, which do not depend on scattering geometry, are used to create a set of corrections for geostationary data that can be used in future studies to analyze the time evolution of clouds from space.
Mitral valve surgery in octogenarians: Identifying factors that can guide clinical decision-making
Authors: Pavlopoulos Dionysios , Mylonas Konstantinos S , Avgerinos Dimitrios , Petsios Konstantinos , Samanidis George , Katsaridis Sotirios , Perreas Konstantinos 
Published: July 2023

Background Mitral valve surgery in octogenarians is a clinical challenge due to the impact of inherent, age-related comorbidities. Within the context of an aging population, the number of mitral surgery candidates over 80 has been gradually increasing. We sought to evaluate our institutional experience with mitral valve surgery in octogenarians to identify factors that may prove useful during the process of clinical decision-making. Methods We retrospectively reviewed our institutional database for all patients over 80 years of age who underwent mitral valve surgery in our department from October 2002 up to February 2021. The primary endpoints of our study were 30-day all-cause mortality and long-term survival after the first postoperative month. Results In total, 99 octogenarians underwent mitral valve surgery for various types of mitral pathology. In particular, 70 patients underwent mitral valve replacement with or without concomitant procedures and 29 underwent mitral valve repair with or without concomitant procedures. There was no difference between the two approaches in terms of 30-day mortality and long-term survival. Chronic kidney disease and total operative time were independent predicting factors for 30-day mortality. Etiology of mitral valve pathology and EuroSCORE II was independent predicting factors for long-term survival. Conclusions The type of mitral valve surgery did not affect 30-day and long-term mortality rates in our study. Renal impairment and EuroSCORE II were independent predictors of 30-day mortality and long-term prognosis, respectively. Rheumatic valve disease was also associated with a poorer prognosis.
Exposure to systemic antibiotics in outpatient care and the risk of multiple sclerosis
Authors: Sipilä Jussi OT , Viitala Matias , Hänninen Arno , Soilu-Hänninen Merja 
Published: July 2023

Background: Infections, early life exposures and the microbiome have been associated with the aetiology of multiple sclerosis (MS). Data on any possible roles of antibiotics is scarce and conflicting. Objective: The objective of this study was to investigate associations between outpatient systemic antibiotic exposure and the risk of MS in a nationwide case-control setting. Methods: Patients with MS were identified from the nation MS registry and their exposure to antibiotics was compared with that of persons without MS, provided by the national census authority. Antibiotic exposure was investigated using the national prescription database and analyzed by Anatomical Therapeutic Chemical (ATC) category. Results: Among the 1830 patients with MS and 12765 control persons, there were no associations between exposure to antibiotics in childhood (5–9 years) or adolescence (10–19 years) and the subsequent risk of MS. There was also no association between antibiotic exposure 1–6 years before disease onset and the risk of MS, save for exposure to fluoroquinolones in women (odds ratio: 1.28; 95% confidence interval: 1.03, 1.60; p = 0.028) which is probably associated with the increased infection burden in the MS prodrome. Conclusion: Use of systemic prescription antibiotics was not associated with subsequent MS risk.
Predicting Rectal Cancer Response to Total Neoadjuvant Treatment Using an Artificial Intelligence Model Based on Magnetic Resonance Imaging and Clinical Data
Authors: Ouyang Ganlu , Chen Zhebin , Dou Meng , Luo Xu , Wen Han , Deng Xiangbing , Meng Wenjian , Yu Yongyang , Wu Bing , Jiang Dan , Wang Ziqiang , Yao Yu , Wang Xin 
Published: July 2023

Purpose To develop a model for predicting response to total neoadjuvant treatment (TNT) for patients with locally advanced rectal cancer (LARC) based on baseline magnetic resonance imaging (MRI) and clinical data using artificial intelligence methods. Methods Baseline MRI and clinical data were curated from patients with LARC and analyzed using logistic regression (LR) and deep learning (DL) methods to predict TNT response retrospectively. We defined two groups of response to TNT as pathological complete response (pCR) versus non-pCR (Group 1), and high sensitivity [tumor regression grade (TRG) 0 and TRG 1] versus moderate sensitivity (TRG 2 or patients with TRG 3 and a reduction in tumor volume of at least 20% compared to baseline) versus low sensitivity (TRG 3 and a reduction in tumor volume <20% compared to baseline) (Group 2). We extracted and selected clinical and radiomic features on baseline T2WI. Then we built LR models and DL models. Receiver operating characteristic (ROC) curves analysis was performed to assess predictive performance of models. Results Eighty-nine patients were assigned to the training cohort, and 29 patients were assigned to the testing cohort. The area under receiver operating characteristics curve (AUC) of LR models, which were predictive of high sensitivity and pCR, were 0.853 and 0.866, respectively. Whereas the AUCs of DL models were 0.829 and 0.838, respectively. After 10 rounds of cross validation, the accuracy of the models in Group 1 is higher than in Group 2. Conclusion There was no significant difference between LR model and DL model. Artificial Intelligence-based radiomics biomarkers may have potential clinical implications for adaptive and personalized therapy.
Xiaoliu Pingyi Recipe Inhibits Lung Pre-Metastatic Niche Formation and Prevents Myeloid-Derived Suppressor Cells Recruitment
Authors: Li Honglin , Yang Feiran , Zhang Lei , Zhao Ruohan , Li Xiurong , Li Huijie 
Published: July 2023

Background: Metastasis, a leading cause of cancer-related deaths, involves complex mechanisms. The premetastatic niche (PMN) is a crucial contributor to this process. Myeloid-derived suppressor cells (MDSCs) play an important role in PMN formation and promote tumor progression and metastasis. The Xiaoliu Pingyi recipe (XLPYR), a traditional Chinese medicine, is effective in preventing postoperative recurrence and metastasis in cancer patients. Objective: This study investigated the effects of XLPYR on MDSCs recruitment and on the expression of PMN markers and elucidated the mechanisms involved in the prevention of tumor metastasis. Methods: C57BL/6 mice were subcutaneously injected with Lewis cells and treated with cisplatin and XLPYR. Tumors were resected after 14 days after the establishment of a model of lung metastasis, and tumor volume and weight were measured. Lung metastases were observed 21 days after resection. MDSCs in the lung, spleen, and peripheral blood were detected by flow cytometry. Western blotting, qRT-PCR and ELISA were used to detect the expression of S100A8, S100A9, MMP9, LOX, and IL-6/STAT3 in premetastatic lung tissue. Results: XLPYR treatment inhibited tumor growth and prevented lung metastasis. Compared to mice without subcutaneous tumor cell transplantation, the model group had an increased proportion of MDSCs, higher expression of S100A8, S100A9, MMP9, and LOX in the premetastatic lung. XLPYR treatment reduced the proportion of MDSCs, S100A8, S100A9, MMP9, and LOX expression, and downregulated the IL-6/STAT3 pathway. Conclusions XLPYR may prevent MDSCs recruitment and reduce the expression of S100A8, MMP9, LOX, and IL6/STAT3 in premetastatic lung tissue, thus reducing lung metastases.
Association between adverse childhood experiences and later-life allostatic load in UK Biobank female participants
Authors: Jakubowski Debbie , Peterson Caryn E , Sun Jiehuan , Hoskins Kent , Rauscher Garth H , Argos Maria 
Published: July 2023

Background: Adverse childhood experiences during key developmental periods have been shown to impact long-term health outcomes. Adverse childhood experiences may include psychological, physical, or sexual abuse; neglect; or socioeconomic factors. Adverse childhood experiences are linked with an increase in poor health behavior such as smoking and alcohol consumption, and may also influence epigenetic changes, inflammatory response, metabolic changes, and allostatic load. Objective: We sought to explore associations between adverse childhood experiences and allostatic load in adult female participants in the UK Biobank. Design: The UK Biobank is a multisite cohort study established to capture lifestyle, environment, exposure, health history, and genotype data on individuals in the United Kingdom. Methods: Adverse childhood experiences were assessed from the Childhood Trauma Screener, which measures abuse and neglect across five items. Biological measures at enrollment were used to construct allostatic load, including measures of metabolic, inflammatory, and cardiovascular function. Females with a cancer diagnosis prior to enrollment were removed as it may influence allostatic load. Poisson regression models were used to assess the association between adverse childhood experiences and allostatic load, accounting for a priori confounders. Results: A total of 33,466 females with complete data were analyzed, with a median age at enrollment of 54 (range = 40–70) years. Among the study sample, the mean allostatic load ranged from 1.85 in those who reported no adverse childhood experiences to 2.45 in those with all adverse childhood experiences reported. In multivariable analysis, there was a 4% increase in average allostatic load among females for every additional adverse childhood experience reported (incidence rate ratio = 1.04, 95% confidence interval = 1.03–1.05). Similar results were observed when assessing individual adverse childhood experience components. Conclusion: This analysis supports a growing body of evidence suggesting that increased exposure to early life abuse or neglect is associated with increased allostatic load in females.