bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal mediation study of peer victimization and resting-state functional connectivity as predictors of development of adolescent psychopathology
Authors: Edalati Hanie , Afzali Mohammad H. , Spinney Sean , Bourque Josiane , Dagher Alain , Conrod Patricia J. 
Published: March 2023

BackgroundPeer victimization (PV) is associated with alterations in neural responses in regions subserving emotional regulatory processes and with increased risk of psychopathology during adolescence. The present study examined the longitudinal mediating effects of resting-state functional connectivity (rsFC) between adolescent PV and subsequent internalizing (depression and anxiety), and externalizing (conduct and hyperactivity/inattention) symptoms.Methods151 adolescents (baseline mean age 12–14; 54% males) were assessed and imaged three times during a five-year period. We focused on rsFC of a priori determined Regions-of-Interest (ROIs) guided by the literature (i.e., amygdala, anterior and posterior insula, anterior cingulate cortex, and medial prefrontal cortex). Multilevel mediation (MLM) analyses simultaneously examined the between-person, concurrent within-person, and lagged within-person associations between PV and internalizing/externalizing symptoms through changes in couplings of the amygdala with the other four ROIs. All models controlled for the effects of self-reported childhood maltreatment and sex differences.ResultsAn increased rsFC of the amygdala-posterior insula significantly mediated the lagged within-person association of PV and internalizing symptoms (β = 0.144; 95% CI [0.018, 0.332]). This effect was significant regardless of childhood maltreatment, concurrent externalizing symptoms, and sex differences. The rsFC did not mediate the relationship between PV and externalizing symptoms.ConclusionsResults of this study suggest that adolescent PV may lead to long-lasting maladaptive neural communication between emotional response and sensory perception of pain (i.e., bottom-up emotion regulation) and that these neural responses may serve as unique markers for increased internalizing symptoms that appear in later adolescence in peer-victimized youth. These findings have implications for interventions targeting internalizing symptoms in victimized adolescents.
The longitudinal predictive effect of self-reported frequency of premenstrual syndrome on depression: Findings from the Australian Longitudinal Study on Women's Health
Authors: Hou Lulu , Chen Lele , Zhang Wenpei 
Published: March 2023

BackgroundPrevious studies have revealed a high comorbidity between premenstrual syndrome (PMS) and depression; however, whether PMS can longitudinally predict depression has not been examined in large sample studies.MethodsThis study surveyed 8,133 women from the 1973–78 cohort of the Australian Longitudinal Study on Women's Health. Participants completed seven repeated measurements at 3-year intervals starting in 2000 (aged 22–27 years). Binary logistic and multivariate ordered logistic regression models were used to examine the predictive role of self-reported frequency of PMS symptoms in 2000 on self-reported diagnosis of depression and frequency of depressive symptoms, respectively, for each follow-up survey.ResultsSelf-reported frequency of PMS symptoms in the year 2000 predicted self-reported diagnosis of depression in most follow-up surveys. Specifically, compared to women who reported “never” had PMS symptoms in 2000, those who reported “often” had them were more likely to report a diagnosis of depression in 2006 (OR = 1.72), 2012 (OR = 1.88), 2015 (OR = 1.49), and 2018 (OR = 1.90); and those who reported “sometimes” had PMS symptoms in 2000 were more likely to report a diagnosis of depression in 2012 (OR =1.37) and 2018 (OR = 1.59). Furthermore, self-reported frequency of PMS symptoms in 2000 predicted self-reported frequency of depressive symptoms in each follow-up survey. Compared to women who reported “never” had PMS symptoms in 2000, those who reported “sometimes”, or “often”, had PMS symptoms reported depressive symptoms more frequently.ConclusionSelf-reported frequency of PMS can predict the self-reported frequency of depressive symptoms and the subsequent diagnosis of depression.
Prevalence and risk factors of posttraumatic stress symptoms among Internally Displaced Christian couples in Erbil, Iraq
Authors: Rofo Sana , Gelyana Lina , Moramarco Stefania , Alhanabadi Luma H. H. , Basa Faiq B. , Dellagiulia Antonio , Emberti Gialloreti Leonardo 
Published: March 2023

BackgroundResearch about the impact of war and displacement experiences on the mental health of Internally Displaced People (IDPs) has recently grown. However, a limited number of studies focus on minorities. The objective of the present preliminary study was to estimate the prevalence of posttraumatic stress symptoms (PTSSs) among IDPs who live outside camps and belong to the Christian minority in Iraq, and to identify possible predictors.MethodsOverall, 108 internally displaced Christians (54 married couples) participated in the study. Traumatic events and PTSSs were assessed using the Harvard Trauma Questionnaire. Multivariable linear regression models were used to investigate possible predictors of PTSSs. Multivariable logistic regression models have been developed to estimate the odds of presenting PTSSs.ResultsResults demonstrated high rates of trauma exposure, with all participants having experienced at least three traumatic events. The estimated prevalence of PTSSs was 20.3%. A low economic status, the number of traumatic events, and a second experience of displacement were associated with increased PTSSs. Five traumatic events were identified as the main predictors of PTSSs.ConclusionFindings from the current preliminary study indicated the impact of war-related traumatic events on IDPs' mental health and the negative effects of post-displacement experiences. These findings may have important implications for setting up psychosocial interventions, as well as for further promoting physical and mental health services among these populations.
Impacts of complex electromagnetic radiation and low-frequency noise exposure conditions on the cognitive function of operators
Authors: Liang Peng , Li Zenglei , Li Jiangjing , Wei Jing , Li Jing , Zhang Shenghao , Xu Shenglong , Liu Zhaohui , Wang Jin 
Published: March 2023

BackgroundBoth electromagnetic radiation (EMR) and low-frequency noise (LFN) are widespread and influential environmental factors, and operators are inevitably exposed to both EMR and LFN within a complex exposure environment. The potential adverse effects of such exposure on human health must be considered seriously. This study aimed to investigate the effects of EMR and LFN on cognitive function as well as their interaction effect, which remain unclear.MethodsSixty young male college students were randomly grouped and experiments were conducted with a 2 × 2 factorial design in a shielded chamber. Mental workload (MWL) levels of the study subjects were measured and assessed using the NASA-task load index (TLX) subjective scale, an n-back task paradigm, and the functional near-infrared spectroscopy (fNIRS) imaging technique.ResultsFor the 3-back task, the NASA-TLX subjective scale revealed a statistically significant main effect of LFN intensity, which enhanced the subjects’ MWL level (F = 8.716, p &lt; 0.01). Behavioral performance revealed that EMR intensity (430.1357 MHz, 10.75 W/m2) and LFN intensity (0–200 Hz, 72.9 dB) had a synergistic interaction effect, and the correct response time was statistically significantly prolonged by the combined exposure (F = 4.343, p &lt; 0.05). The fNIRS imaging technique revealed a synergistic interaction effect between operational EMR intensity and operational LFN intensity, with statistically significant effects on the activation levels in the left and right dorsolateral prefrontal cortex (DLPFC). The mean β values of DLPFC were significantly increased (L-DLPFC F = 5.391, p &lt; 0.05, R-DLPFC F = 4.222, p &lt; 0.05), and the relative concentrations of oxyhemoglobin in the DLPFC were also significantly increased (L-DLPFC F = 4.925, p &lt; 0.05, R-DLPFC F = 9.715, p &lt; 0.01).ConclusionWe found a statistically significant interaction effect between EMR (430.1357 MHz, 10.75 W/m2) and LFN (0–200 Hz, 72.9 dB) when simultaneously exposing subjects to both for 30 min. We conclude that exposure to this complex environment can cause a statistically significant increase in the MWL level of operators, and even alterations in their cognitive function.
Current evidence shows no influence of women's menstrual cycle phase on acute strength performance or adaptations to resistance exercise training
Authors: Colenso-Semple Lauren M. , D'Souza Alysha C. , Elliott-Sale Kirsty J. , Phillips Stuart M. 
Published: March 2023

IntroductionThe bias towards excluding women from exercise science research is often due to the assumption that cyclical fluctuations in reproductive hormones influence resistance exercise performance and exercise-induced adaptations.MethodsHence, the purpose of this umbrella review was to examine and critically evaluate the evidence from meta-analyses and systematic reviews on the influence of menstrual cycle phase on acute performance and chronic adaptations to resistance exercise training (RET).ResultsWe observed highly variable findings among the published reviews on the ostensible effects of female sex hormones on relevant RET-induced outcomes, including strength, exercise performance, and hypertrophy.DiscussionWe highlight the importance of comprehensive menstrual cycle verification methods, as we noted a pattern of poor and inconsistent methodological practices in the literature. In our opinion, it is premature to conclude that short-term fluctuations in reproductive hormones appreciably influence acute exercise performance or longer-term strength or hypertrophic adaptations to RET.
Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production
Authors: Andreo-Vidal Andrés , Yushchuk Oleksandr , Marinelli Flavia , Binda Elisa 
Published: March 2023

Teicoplanin and A40926 (natural precursor of dalbavancin) are clinically relevant glycopeptide antibiotics (GPAs) produced by Actinoplanes teichomyceticus NRRL B-16726 and Nonomuraea gerenzanensis ATCC 39727. Their biosynthetic enzymes are coded within large biosynthetic gene clusters (BGCs), named tei for teicoplanin and dbv for A40926, whose expression is strictly regulated by pathway-specific transcriptional regulators (PSRs), coded by cluster-situated regulatory genes (CSRGs). Herein, we investigated the “cross-talk” between the CSRGs from tei and dbv, through the analysis of GPA production levels in A. teichomyceticus and N. gerenzanensis strains, with knockouts of CSRGs cross-complemented by the expression of heterologous CSRGs. We demonstrated that Tei15* and Dbv4 StrR-like PSRs, although orthologous, were not completely interchangeable: tei15* and dbv4 were only partially able or unable to cross-complement N. gerenzanensis knocked out in dbv4 and A. teichomyceticus knocked out in tei15*, implying that the DNA-binding properties of these PSRs are more different in vivo than it was believed before. At the same time, the unrelated LuxR-like PSRs Tei16* and Dbv3 were able to cross-complement corresponding N. gerenzanensis knocked out in dbv3 and A. teichomyceticus knocked out in tei16*. Moreover, the heterologous expression of dbv3 in A. teichomyceticus led to a significant increase in teicoplanin production. Although the molecular background of these events merits further investigations, our results contribute to a deeper understanding of GPA biosynthesis regulation and offer novel biotechnological tools to improve their production.
Antimicrobial and Osteogenic Effects of Collagen Membrane Decorated with Chitosan–Nano-Hydroxyapatite
Authors: Lazarevic Milos , Petrovic Sanja , Pierfelice Tania Vanessa , Ignjatovic Nenad , Piattelli Adriano , Vlajic Tovilovic Tamara , Radunovic Milena 
Published: March 2023

Collagen membranes are routinely used in oral surgery for bone regeneration. Despite their numerous advantages, such as stimulating bone growth, bacterial contamination still remains one of the disadvantages of membrane use. Thus, we assessed the biocompatibility and osteogenic and antibacterial properties of a collagen membrane (OsteoBiol) modified with chitosan (CHI) and hydroxyapatite nanoparticles (HApNPs). Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR FT-IR), X-ray powder diffraction (XRD), and field emission scanning electron microscopy (FE-SEM) were performed for membrane characterization. Biocompatibility was assessed on dental pulp stem cells (DPSCs) by an MTT assay, while the osteogenic effect was assessed by an ALP activity assay and qPCR analysis of osteogenic markers (BMP4, ALP, RUNX2, and OCN). Antimicrobial properties were investigated by counting colony-forming units (CFUs) of Streptococcus mitis, Porphyromonas gingivalis, and Fusobaterium nucleatum on membranes and in the surrounding medium. Membranes showed no cytotoxicity. ALP activity was higher and ALP, BMP4, and OCN genes were up-regulated in DPSCs on modified membranes compared to unmodified membranes. The CFUs were reduced on modified membranes and in the medium. Modified membranes showed great biocompatibility and a high osteoinductive effect. Additionally, they showed antimicrobial and antibiofilm effects against periopathogens. It can be concluded that the incorporation of CHI and hydroxyapatite nanoparticles in collagen membranes may be advantageous to promote osteogenesis and reduce bacterial adhesion.
The Arabidopsis Deubiquitylase OTU5 Suppresses Flowering by Histone Modification-Mediated Activation of the Major Flowering Repressors FLC, MAF4, and MAF5
Authors: Radjacommare Ramalingam , Lin Shih-Yun , Usharani Raju , Lin Wen-Dar , Jauh Guang-Yuh , Schmidt Wolfgang , Fu Hongyong 
Published: March 2023

Distinct phylogeny and substrate specificities suggest that 12 Arabidopsis Ovarian Tumor domain-containing (OTU) deubiquitinases participate in conserved or plant-specific functions. The otu5-1 null mutant displayed a pleiotropic phenotype, including early flowering, mimicking that of mutants harboring defects in subunits (e.g., ARP6) of the SWR1 complex (SWR1c) involved in histone H2A.Z deposition. Transcriptome and RT-qPCR analyses suggest that downregulated FLC and MAF4-5 are responsible for the early flowering of otu5-1. qChIP analyses revealed a reduction and increase in activating and repressive histone marks, respectively, on FLC and MAF4-5 in otu5-1. Subcellular fractionation, GFP-fusion expression, and MNase treatment of chromatin showed that OTU5 is nucleus-enriched and chromatin-associated. Moreover, OTU5 was found to be associated with FLC and MAF4-5. The OTU5-associated protein complex(es) appears to be distinct from SWR1c, as the molecular weights of OTU5 complex(es) were unaltered in arp6-1 plants. Furthermore, the otu5-1 arp6-1 double mutant exhibited synergistic phenotypes, and H2A.Z levels on FLC/MAF4-5 were reduced in arp6-1 but not otu5-1. Our results support the proposition that Arabidopsis OTU5, acting independently of SWR1c, suppresses flowering by activating FLC and MAF4-5 through histone modification. Double-mutant analyses also indicate that OTU5 acts independently of the HUB1-mediated pathway, but it is partially required for FLC-mediated flowering suppression in autonomous pathway mutants and FRIGIDA-Col.
Echinophora tenuifolia subsp. sibthorpiana—Study of the Histochemical Localization of Essential Oil
Authors: Ivanova Stanislava , Dyankov Stanislav , Karcheva-Bahchevanska Diana , Todorova Velislava , Georgieva Yoana , Benbassat Niko , Ivanov Kalin 
Published: March 2023

Background: Echinophora tenuifolia L. subsp. sibthorpiana is a perennial, aromatic plant used in traditional folk medicine and cuisine of the Mediterranean and the Middle East. However, scholars have not fully studied the pharmacological potential of the herb, and the scientific data on this plant species are limited. This study aimed to evaluate the chemical composition of the essential oil (EO) obtained from the aerial parts of E. tenuifolia subsp. sibthorpiana growing wild in Bulgaria and to perform histochemical analysis. Methods: A microscopic histochemical analysis and gas chromatography with mass spectrometry were performed. Results: The histochemical analysis confirmed the presence of terpenes in the stem and leaf of E. tenuifolia subsp. sibthorpiana. The phenylpropanoid methyleugenol was identified as the main compound in the EO, representing 48.13% of the total oil composition. There were also found considerable amounts of monoterpene hydrocarbons, representing 41.68% of the total EO. Alpha-phellandrene, o-cymene, and β-phellandrene were the most abundant monoterpene hydrocarbons. Conclusion: This is the first histochemical analysis performed on E. tenuifolia subsp. sibthorpiana. This is the first report of the EO composition from Bulgarian E. tenuifolia subsp. sibthorpiana, and our results indicate some future possibilities for evaluating of the biological activity of the EO of E. tenuifolia subsp. sibthorpiana and highlight the potential future use of the EO of this plant species. E. tenuifolia L. subsp. sibthorpiana EO possesses a good potential for use as a biopesticide and repellent an environmentally friendly alternative of synthetic pesticides.
Investigation of high speed β-Ga2O3 growth by solid-source trihalide vapor phase epitaxy
Authors: Nitta Kyohei , Sasaki Kohei , Kuramata Akito , Murakami Hisashi 
Published: March 2023

Abstract
Trihalide vapor phase epitaxy (THVPE) is a new type of halide vapor phase epitaxy (HVPE) that uses GaCl3 as a group III source, enabling Ga2O3 growth without particle generation, although the growth rate is low. In this study, β-Ga2O3 is grown by THVPE using solid GaCl3 as a group III precursor. The growth rate increases linearly with increasing partial pressure of the precursor. The dependence of the growth rate on the VI/III ratio is revealed on sapphire substrates, with the growth rate reaching a maximum at a VI/III ratio of 95. We have also obtained a growth rate of 32.2 μm h−1 on β-Ga2O3 (001) substrates with no particle generation, crystal quality equivalent to that of the substrate, and high purity equivalent to that of HVPE.
EFFECT OF ULTRAFAST HEATING ON AISI 441 FERRITIC STAINLESS STEEL
Authors: Stornelli Giulia , Albini Luciano , Di Nunzio Paolo Emilio , Tiracorrendo Giulia , Rodriguez Vargas Bryan Ramiro , Di schino Andrea 
Published: March 2023

The use of the ultrafast heating (UFH) heat treatment process attracted great attention in the last few years, following the requirements of CO2 emissions reduction. The
effect of ultrafast heating (UFH) treatment an AISI 441 ferritic stainless steels is reported in this paper. Results show that a minimum temperature of 975 °C is required in order to achieve a fully recrystallized microstructure. The study highlights the effect of ultrarapid annealing on grain size evolution as a function of different adopted process parameters. The obtained microstructure is related to mechanical properties in terms of ultimate tensile stress and hardness.
Stability analysis of short duration rice genotypes in Telangana using AMMI and GGE Bi-plot models
Authors: Chandramohan Y. , Krishna L. , Srinivas B. , Rukmini K. , Sreedhar S. , Prasad K. Shiva , Kishore N. Sandhya , Rani Ch. V. Durga , Singh T. V. J. , Jagadeeshwar R. 
Published: March 2023

In order to identify stable short duration rice genotypes across different agro-climatic zones in Telangana state, Additive Main Effects and Multiplicative Interaction Models (AMMI) and GGE Bi-plot analyses was performed. Analysis of variance clearly revealed that genotypes contributed highest (34.57 %) followed by environments (32.31 %) and genotype environment interaction (17.10 %) in total sum of squares indicating very greater role played by genotypes, environments and their interactions in realizing final grain yield. AMMI analysis revealed that rice genotypes viz., KNM 2305 (G12), KNM 2307 (G16) and JGL 20776 (G9) were recorded higher mean grain yield with positive interactive principal component analysis 1 (IPCA1) scores whereas, KNM 2307 (G16) and RNR 23595 (G5) were plotted near to zero IPCA1 axis indicating relatively more stable performance across locations. However, the GGE Bi-plot genotype view depicts that the genotypes viz., RDR 1188 (G6) and KNM 2305 (G12) were known as highly unsteady across locations. Among environments, Rudrur (E4), Kunaram (E2) and Rajendranagar (E5) locations were identified as relatively ideal to realize good yields whereas Jagtial (E1), Kampasagar (E3) and Warangal (E6) locations were poor and most discriminating. Among the six locations, the performance of genotypes was relatively similar in Kunaram (E2), Kampasagar (E3) and Rudrur (E4), Warangal (E6) though they belong to different agro-climatic zones of Telangana state, whereas Jagtial (E1) location seems to be little divergent. Further, KNM 2305 (G12) and US 314 (G17) were performed better at Jagtial (E1) and Rajendranagar (E5) while MTU 1010 (G8) was found to have good performance in Rudrur (E4) and Warangal (E6) locations. The results conclude that KNM 2305 was high yielder but found to be unstable across locations whereas KNM 2307 (G16) and KPS 6251 (G15) were identified as good with reasonably higher grain yield and stable performance over locations.