bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydropneumothorax caused by complete rupture of a pulmonary hydatid cyst: A rare case report
Authors: Almousa Maher , Alhadla Ahmad , Aljomaa Mohammad , Abdalrazzak Tamim 
Published: July 2023

Key Clinical MessageHydatid disease is a zoonotic disease endemic in developing regions. It is usually caused by infection with the tapeworm Echinococcus granulosus due to contaminated food or drinks or by close contact with dogs. The lungs are the second most affected organ (25%) after the liver (>65%). Cyst rupture is the most frequent complication. Enlarging pulmonary cysts are more vulnerable to rupture, with rupturing in the bronchial tree being the most common (20%–40%). Hydropneumothorax is a consequence of complete cyst rupture into the pleural cavity and occurs in rare cases (2%–4%). Superinfection is a common complication of the ruptured cyst, which might lead to empyema. A 26‐year‐old male presented to our clinic with dyspnea that had progressed recently and made him unable to walk a few meters. He had a history of cough and exertional dyspnea and was examined by three different clinics without performing a chest X‐Ray. Physical examination revealed fever and a sick appearance. Chest X‐ray revealed complete pneumothorax with an air‐fluid level in the left hemithorax. Computerized tomography demonstrated two cysts, and one of them was ruptured, causing hydropneumothorax and empyema. The patient was treated with surgery, and follow‐up showed recovery with a fully re‐expanded lung. Rupture of pulmonary hydatid cyst is seen in the most of cases, the clinicians must be aware of such presentation and management of the pulmonary hydatid disease.
Bernard Soulier syndrome: A case report from Pakistan
Authors: Effendi Iqra , Nadeem Ahsan , Sarfraz Sara , Shahid Mubasshar , Farooq Minaam , Anand Ayush 
Published: July 2023

Key Clinical MessageBernard Soulier Syndrome should be suspected in patients with bleeding disorder symptoms and significant family history, where consanguineous marriages are common. Diagnosis can be confirmed using a ristocetin test and a peripheral blood smear.
Path loss model based on exponential water cycle algorithm for wireless sensor network
Authors: Rayar Vijay , Naik Udaykumar 
Published: July 2023

SummaryWireless sensor networks (WSNs) are frequently employed in the agriculture field to improve the quality and crop yield. The WSN might reduce the quality of the communication link because of the absorption, dispersion, and attenuation through the leaves of plants. Therefore, estimating the path loss due to signal attenuation before WSN deployment is crucial for the smooth operation of the network. In this research paper, three innovative path loss models are defined based on the MATLAB curve fitting tool: polynomial water cycle (PWC), exponential water cycle (EWC), and Gaussian water cycle (GWC) algorithm. Here, the path loss between the router node and the coordinator node is modeled on the basis of the received signal strength indicator (RSSI) and time of arrival (TOA) measurements in a sugarcane field. The correlation coefficient between the RSSI measurement and the distance must be increased to create a precise path loss model. This paper integrates the exponential, polynomial, and Gaussian functions with the water cycle algorithm (WCA) to evaluate the optimal coefficients that would lead to precise path loss models. The performance of the proposed models that determines the optimum linear fit between RSSI and distance is validated using the correction coefficient
. The results show that the proposed path loss model is superior to existing path loss models. The correlation coefficient
of the proposed EWC model is 0.9993, whereas the existing PE‐PSO, LNSM, and PSO‐Exponential models yield 0.98, 0.87, and 0.93, respectively. Also, the proposed models attain the best mean absolute error (MAE) of 0.2187, 0.2951, and 0.3457 dBm for EWC, PWC, and GWC algorithms, respectively.
Trends in the incidence of dementia in people with hypertension in the UK 2000 to 2021
Authors: Adesuyan Matthew , Jani Yogini H. , Alsugeir Dana , Howard Robert , Wong Ian C. K. , Wei Li , Brauer Ruth 
Published: July 2023

AbstractINTRODUCTIONWe investigated trends in the incidence of dementia in UK adults with hypertension.METHODSPrimary care electronic health records from IQVIA Medical Research Data UK, previously known as THIN, were used to identify 2,133,118 adults aged ≥40 years with hypertension over 2000 to 2021. The annual incidence rate and average annual percentage change in recorded dementia diagnoses were estimated and stratified by sex, 10‐year age bands, Townsend deprivation quintiles and dementia subtype.RESULTSThe crude incidence rate of dementia in people with hypertension increased from 1.98 (95% confidence internal [CI] 1.89–2.07) per 1000 person‐years at risk (PYAR) in 2000 to 5.29 per 1000 PYAR (95% CI 5.07–5.53) in 2021, corresponding to an average annual increase of 4.1% (95% CI 3.3–5.0). Those aged ≥80 years, the most economically deprived (Townsend = 5), and Alzheimer's disease subtype reported the highest incidence rate within their respective categories.DISCUSSIONThe annual incidence rate of dementia in the hypertensive population has increased over the last 22 years.Highlights
New dementia diagnosis in the hypertensive population has increased over 22 years.
The Alzheimer's disease subtype reported the highest incidence rate in people with hypertension.
Difference in dementia incidence between hypertensive females and males has reduced.
Difference in dementia incidence among deprivation categories has reduced in recent years.
Nonparametric assessment of mangrove ecosystem in the context of coastal resilience in Ghana
Authors: Aja Daniel , Miyittah Michael , Angnuureng Donatus Bapentire 
Published: July 2023

AbstractCloud cover effects make it difficult to evaluate the mangrove ecosystem in tropical locations using solely optical satellite data. Therefore, it is essential to conduct a more precise evaluation using data from several sources and appropriate models in order to manage the mangrove ecosystem as effectively as feasible. In this study, the status of the mangrove ecosystem and its potential contribution to coastal resilience were evaluated using the Google Earth Engine (GEE) and the InVEST model. The GEE was used to map changes in mangrove and other land cover types for the years 2009 and 2019 by integrating both optical and radar data. The quantity allocation disagreement index (QADI) was used to assess the classification accuracy. Mangrove height and aboveground biomass density were estimated using GEE by extracting their values from radar image clipped with a digital elevation model and mangrove vector file. A universal allometric equation that relates canopy height to aboveground biomass was applied. The InVEST model was used to calculate a hazard index of every 250 m of the shoreline with and without mangrove ecosystem. Our result showed that about 16.9% and 21% of mangrove and other vegetation cover were lost between 2009 and 2019. However, water body and bare land/built‐up areas increased by 7% and 45%, respectively. The overall accuracy of 2009 and 2019 classifications was 99.6% (QADI = 0.00794) and 99.1% (QADI = 0.00529), respectively. Mangrove height and aboveground biomass generally decreased from 12.7 to 6.3 m and from 105 to 88 Mg/ha on average. The vulnerability index showed that 23%, 51% and 26% of the coastal segment in the presence of mangrove fall under very low/low, moderate and high risks, respectively. Whereas in the absence of mangrove, 8%, 38%, 39% and 15% fall under low, moderate, high and very high‐risk zones, respectively. This study will among other things help the stakeholders in coastal management and marine spatial planning to identify the need to focus on conservation practices.
Global review and guidelines to avoid opportunistic predation of birds and bats in mist nets
Authors: de Moura Guilherme Wince , Mustin Karen , Pinto Fernando Antonio Silva , Sineiro Sylvia Coelho Alves , Xavier Bruna da Silva , Costa Luciana Moraes , Esbérard Carlos Eduardo Lustosa , Barufatti Alexeia , Carvalho William Douglas 
Published: July 2023

AbstractMist nets are one of the most widely used techniques in the study of birds and bats worldwide. However, a number of risks are involved, including opportunistic predation. Given this potential cost, here we: (1) review the global literature to understand the factors that might contribute to predation risk for birds and bats captured in mist nets; (2) review existing guidelines for best practice use of mist nets; and (3) based on our reviews, recommend new guidelines for the use of mist nets to minimize the risk of opportunistic predation. Based on keyword in English, Spanish, Portuguese, and French, and using Google Scholar, Scopus, SciElo, and Web of Science, we found 48 articles reporting opportunistic predation. In the included articles, 178 predation events, involving 52 predator and 84 prey species, were reported. In most of the reports, the mist nets were placed at ground level, the bats and birds were preyed on from the shelf closest to the ground, the mist‐net checks occurred at intervals of 1 h or 30 min and the most common predators were arboreal and scansorial species (primates and marsupials). Despite the occurrences of predation in 13 countries, guidelines for best practice mist‐net use were found in only three, despite extensive searches and contact with key people in each country. Based on the existing guidelines and our results, we recommend that mist nets be fixed with the lowest shelf at least 50 cm above ground level and be checked at 15‐min intervals; when predators are observed near mist nets, the nets either be constantly observed, closed, or relocated; suppressed the vegetation around the mist nets; captured animals be removed from the mist nets as soon as possible, and more than one researcher/technician should be in the field at all times.
Characterization of the Ligand Field in Pseudo‐Octahedral Ni(II) Complexes of Pincer‐Type Amido Ligands: Magnetism, Redox Behavior, Electronic Absorption and High‐Frequency and ‐Field EPR Spectroscopy
Authors: Ortiz Robert J. , Shepit Michael , van Lierop Johan , Krzystek J. , Telser Joshua , Herbert David E. 
Published: July 2023

AbstractThe description of π‐donor amido moieties as ‘weak‐field’ ligands can belie the influence of metal‐ligand covalency on the overall ligand field of coordination complexes, which can in turn influence properties including the magnetic ground state and those of their excited states. In this contribution, the ligand fields of pseudo‐octahedral Ni(II) complexes supported by diarylamido pincer‐type amido ligands – three previously reported examples supported by asymmetric (2‐R‐phenanthridin‐4‐yl)(8‐quinolinyl)amido ligands (R = Cl, CF3,tBu;RL1) along with a new congener bearing a symmetricbis(8‐quinolinyl)amido ligand (BQA;L2) – were investigated in two ways. First, high‐frequency and ‐field electron paramagnetic resonance spectroscopy (HFEPR), SQUID magnetometry, and electronic absorption spectroscopy were used to determine the ligand field parameters. Second, the ability to electrochemically address ligand‐based oxidations despite metal‐centered SOMOs in the parentS=1 paramagnets was investigated, supported by time‐dependent density functional theory (TDDFT) identification of strong intervalence charge‐transfer (IVCT) transitions attributed to electronic communication between two Namidomoieties mediated by a Ni(II) bridge. These findings are discussed in the broader context of 3d transition metal coordination complexes of weak‐field π‐donor ligands.
Optical, vibrational, electrical, and electrochemical studies of new plasticized methylcellulose‐based solid polymer electrolytes for supercapacitor application
Authors: Azemtsop Theodore Manfo 
Published: July 2023

AbstractIn this work, new plasticized solid polymer electrolytes (SPEs) are developed using MC (methylcellulose) as a polymer host, and sodium iodide (NaI) as a dopant via the solution casting method. Ethyl carbonate (EC) is used as a plasticizing agent to improve the properties of the SPEs. Polarized optical microscopy analysis reveals that the surface morphology of the MC‐NaI‐EC films contained porous amorphous regions owing to the presence of EC. The complex formation between MC, NaI, and EC is confirmed by Fourier‐transform infrared spectra. The addition of EC in the MC‐NaI polymer salt matrix enhances the electrochemical properties of the prepared films. The highest ionic conductivity of 5.06×10−3 S/cm is achieved for the composition: MC+50 wt. % NaI +10 wt. % EC. The linear sweep voltammetry test reveals that the optimal plasticized‐SPE can withstand up to 2.5 V. The ionic transference number analysis reveals that 99% of ions contribute to the total conductivity. The optimized SPE film and graphene oxide‐based electrodes are used to manufacture a solid‐state electrical double‐layer capacitor. The coulomb efficiency of the supercapacitor cell is 100%, and the specific capacitance of the supercapacitor is found to be 18.56 F/g utilizing impedance data at low frequency.
Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review
Authors: Bian Jialu , Zhao Jinxia , Zhao Yinyu , Hao Xu , He Shiyu , Li Yuanyuan , Huang Lin 
Published: July 2023

AbstractIndividual differences in drug response have always existed in clinical treatment. Many non‐genetic factors show non‐negligible impacts on personalized medicine. Emerging studies have demonstrated epigenetic could connect non‐genetic factors and individual treatment differences. We used systematic retrieval methods and reviewed studies that showed individual factors’ impact on DNA methylation of drug metabolism genes. In total, 68 studies were included, and half (n = 36) were cohort studies. Six aspects of individual factors were summarized from the perspective of personalized medicine: parental exposure, environmental pollutants exposure, obesity and diet, drugs, gender and others. The most research (n = 11) focused on ABCG1 methylation. The majority of studies showed non‐genetic factors could result in a significant DNA methylation alteration in drug metabolism genes, which subsequently affects the pharmacokinetic processes. However, the underlying mechanism remained unknown. Finally, some viewpoints were presented for future research.
Predictive factors of genetic diagnosis and real‐life impact of next‐generation sequencing for children with epilepsy
Authors: Pinto Gustavo Moura da Mata Machado Ferreira , Fidalski Solena Ziemer Kusma , Santos Mara Lúcia Schmidt Ferreira , de Souza Josiane , do Valle Daniel Almeida 
Published: July 2023

AbstractObjectiveIdentify the predictive variables of genetic pathogenic results and the impact of test results on epilepsy diagnosis and management.MethodsAnalytical observational design evaluated 130 patients with epilepsy that had performed genetic testing over January 2017 to July 2022.ResultsThere was a gradual increase in the number of exams performed over the years. The frequency of pathogenic results was 34% (n = 44/130), 8 altered genes with 54% (n = 24/44) of the results. The tests were more positive in patients with developmental delay and/or regression (p = .01). None of the other factors analyzed were associated with higher diagnostic yield. The age at onset of epilepsy brought diagnostic yield to the test (p = .041). Patients with negative genetic test had a reduction in the number of electroencephalograms performed before and after the test (respectively, 3.80 ± 6.37 and .84 ± 1.67; p < .001).SignificanceFacing a large proportion of patients with unexplained epilepsy have a genetic cause a genetic test has the potential to reduce the use of unnecessary diagnostic tests, improve patient outcomes by identifying targeted treatments, and provide families with genetic counseling and risk assessment. But an early genetic testing can be crucial to reach these goals. Even in cases where the genetic test is negative, the study suggests that it still has important implications for patient care and management.
Anticancer assessment and antibiofilm potential of Laetiporus sulphureus mushroom originated from Serbia
Authors: Jovanović Milena M. , Marković Katarina G. , Grujović Mirjana Ž. , Pavić Jelena , Mitić Milan , Nikolić Jelena , Šeklić Dragana 
Published: July 2023

AbstractLaetiporus sulphureus (Bull.) Murrill is a well‐known edible mushroom consumed in nutrition as delicacy. It has been used in traditional medicine because of its beneficial effects on human wellness, such as antimicrobial, antioxidant, and anticancer potential. The present study determined the phenolic profile of Laetiporus sulphureus ethanolic extract (LSE) by high‐performance liquid chromatographic method. Tolerance of two probiotic bacterial strains Lactiplantibacillus plantarum 229v, Bifidobacterium animalis subsp. lactis and probiotic yeast Saccharomyces boulardii on LSE was analyzed in terms of viability and biofilm formation. Effects of extract on colorectal (HCT‐116) and cervical (HeLa) cancer cells viability was determined using MTT test in concentration range: 1–500 μg/mL after 24 and 72 h. Redox parameters (superoxide anion radicals, nitrites, and reduced glutathione) were evaluated using NBT, Griess, and GSH assays in the concentration range of 1–500 μg/mL after 24 and 72 h. Antimigratory activity was determined by wound healing method using selected concentrations of 10 and 50 μg/mL after 24 h. Untreated cells were considered as control. As control cell line, we used healthy fibroblasts (MRC‐5). Our results demonstrated abundance of LSE in phenolics, with rosmarinic acid as the main component. LSE induced low tolerance of tested planktonic probiotic strains, with no affection on their ability to form biofilm. No significant cytotoxicity on tested cancer cells was observed, with prooxidative and antimigratory effects noticed. Extract exerted significant antimigratory activity on cancer cells without effect on planktonic and probiotic cultures in biofilm. These results indicate potential application of Laetiporus sulphureus ethanolic extract as natural protector of probiotics with prominent ability to suppress cancer cell motility.
Optimization of extraction condition for platycodin D from Platycodon grandiflorum root and verification of its biological activity
Authors: Jung Jihyeon , Cho Yeon Jin , Jeong Minju , Lee Seung‐Su , Kim Jong Hun , Kim Jong‐Eun , Kim Nara , Lee Jiyun , Park Jung Han Yoon , Lee Ki Won , Lee Sung‐Young 
Published: July 2023

AbstractPlatycosides, major components of Platycodon grandiflorum (PG) extract, have been implicated in a wide range of biological effects. In particular, platycodin D (PD) is a well‐known main bioactive compound of Platycosides. Despite the biological significance of PD, optimization of extract condition for PD from PG root has not been well investigated. Here, we established the optimum extraction condition as ethanol concentration of 0%, temperature of 50°C, and extraction time of 11 h to obtain PD‐rich P. grandiflorum extract (PGE) by using response surface methodology (RSM) with Box–Behnken design (BBD). The 5.63 mg/g of PD was extracted from the PG root in optimum condition, and this result was close to the predicted PD content. To analyze the biological activity of PGE related to mucin production, we demonstrated the inhibitory effect of PGE on PMA‐induced hyperexpression of MUC5AC as well as ERK activation, a signal mediator of MUC5AC expression. Moreover, we showed that PGE had expectorant activity in mice. These results indicated that PGE had sufficient functions as a potential mucoregulator and expectorant for treating diverse airway diseases. Additionally, we confirmed that PGE had antioxidant activity and inhibited LPS‐induced proinflammatory cytokines, TNF‐α, and IL‐6. Taken together, PGE derived from novel optimizing conditions showed various biological effects, suggesting that PGE could be directly applied to the food industry as food material having therapeutic and preventive potential for human airway diseases.
Zinc finger protein 335 mediates lipopolysaccharide‐induced neurodegeneration and memory loss as a transcriptional factor in microglia
Authors: Kong Wei , Xie Zhen , Shang Xiaokang , Hayashi Yoshinori , Lan Fei , Narengaowa  , Zhao Shuxuan , Li Hui , Quan Zhenzhen , Wu Zhou , Nakanishi Hiroshi , Qing Hong , Ni Junjun 
Published: July 2023

AbstractZinc finger protein 335 (Zfp335) is a transcription factor that regulates mammalian neurogenesis and neuronal differentiation. It is a causative factor for severe microcephaly, small somatic size, and neonatal death. Here, we evaluated the effects of Zfp335 in the adult mouse brain after lipopolysaccharide (LPS) challenge. We used wild‐type (WT) and Zfp335 knock‐down (Zfp335+/−) mice with LPS administered in the intracerebral ventricle in vivo and cultured microglia treated with LPS in vitro. The impact of Zfp335 was evaluated by RT‐PCR, RNA‐sequencing, western blotting, immunocytochemistry, ELISA, and the memory behavior tests. Knockdown of Zfp335 expression ameliorated microglia activation significantly, including reduced mRNA and protein expression of Iba1, reduced numbers of microglia, reduced cell diameter, and increased branch length, in the brains of 2‐month‐old mice after LPS treatment. Zfp335 was expressed in microglia and neurons, but increased in microglia, not neurons, in the brain of mice after LPS administration. LPS‐induced microglia‐mediated neurodegeneration was dependent upon microglial Zfp335 controlled by nuclear factor‐kappa B. Microglial Zfp335 affected neuronal activity through transcriptional regulation of lymphocyte antigen‐6M (Ly6M). Our data suggest that Zfp335 is a key transcription factor that exacerbates microglia‐mediated neurodegeneration through upregulation of Ly6M expression. Inhibition of microglial Zfp335 may be a new strategy for preventing brain disease induced by microglia activation.
Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review
Authors: Ahmadi Mohammad Hossein , Sharifi Zohreh , Ghasemi Ali , Abbasian Sadegh 
Published: July 2023

AbstractBackgroundOccult hepatitis B infection (OBI) is a transfusion‐transmitted infection. Although, screening the hepatitis B virus among blood donors can play an important role in increasing the health of blood products, OBI screening in blood transfusion centers is still a challenge. This review study aimed to appraise the challenges of OBI screening and its associated do's and don'ts in blood transfusion centers.MethodsIn this review study, a search was conducted on the electronic databases of PubMed, Web of Science, Scopus, Ovid, Irandoc, and Magiran from January 1996 to December 2020. Also, cross‐sectional studies that determined the prevalence of OBI or anti‐HBc were included in the study. In addition, studies with incomplete data on the prevalence of OBI were excluded.ResultsThe prevalence of OBI varies among Iranian blood donors. The rates reported by blood transfusion centers of Mashhad, Ahvaz, and Tehran were 0%, and Isfahan, Shiraz, and Kerman were 0.9%, 0.08%, and 2.36%, respectively. In areas with high prevalence of hepatitis B virus, OBI screening only by anti‐HBc test led to the exemption of blood donors from donating blood. Avoiding OBI screening also effected the risk of virus transmission to blood recipients. Plasma products had a higher risk (85%) of virus transmission.ConclusionsDetermining an appropriate screening strategy based on prevalence status, the cost‐effectiveness of screening tests, and the policies of each blood transfusion center is essential.