bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychopathology, cortisol and testosterone responses to traumatic images: differences between urban and suburban citizens in a middle-income country
Authors: Mayagoitia-Novales Lilian , Cerda-Molina Ana Lilia , Mendoza-Mojica Sheila Adriana , Borráz-León Javier I. , Hernández-Melesio M. Alejandra , Saldívar-Hernández Gabriela Josefina 
Published: July 2023

BackgroundLiving in urban places has been associated with a higher risk of psychopathology as well as with altered hypothalamus–pituitary–adrenal (HPA) axis and consequently altered cortisol response, but studies have concentrated mainly in high-income countries population. The role of other hormones such as testosterone, implicated in stress response and with human social behaviors, have not yet been investigated. The aim of this study was to compare symptoms of psychopathology as well as cortisol and testosterone in response to traumatic images between urban and suburban people in a middle-income country.MethodsA sample of 67 women and 55 men (N = 122, 18–45 years) from urban and suburban places of Mexico participated in the study. We quantified salivary cortisol and testosterone in response to images with traumatic and violent content (basal, 15, 30, and 45 min after images). Participants answered a general information questionnaire and the Symptom Checklist-90-R to assess their psychopathological traits. We performed Generalized Estimating Equation Models to analyze hormonal levels and MANOVAs to compare differences in participants’ psychopathology symptoms. Area under the curve respect to ground (AUCG) of hormonal levels and sex differences were also compared.ResultsSuburban citizens showed no cortisol response, whereas urban people showed a cortisol peak 15 min after the image’s exposure; however, suburban people had higher AUCG and basal levels compared to urban ones. Contrastingly, testosterone levels declined in all participants excepting the urban women, who showed no testosterone response. Although similar testosterone profile, AUCG levels were higher in urban than suburban men. Participants living in suburban areas had higher scores of somatizations, obsessive–compulsive, and interpersonal sensitivity, as well as more sleep disorders than participants living in urban areas.ConclusionThis study offers novel evidence about differences in cortisol and testosterone responses to a social stressor and in mental health indicators between a population of urban and suburban citizens, highlighting the impact of urbanization process on physiological and psychological outcomes in a middle-income country.
Key predictors of psychological distress and wellbeing in Australian frontline healthcare workers during COVID-19 (Omicron wave)
Authors: Lee Brian En Chyi , Ling Mathew , Boyd Leanne , Olsson Craig A. , Sheen Jade 
Published: July 2023

IntroductionThe COVID-19 pandemic has led to significant challenges for frontline healthcare workers’ (FHW), raising many mental health and wellbeing concerns for this cohort. To facilitate identification of risk and protective factors to inform treatment and interventions, this study investigated key predictors of psychological distress and subjective wellbeing in FHWs.MethodsDuring the Omicron wave of the COVID-19 pandemic (January 2022), Victorian (Australia) doctors, nurses, allied health and non-medical staff from Emergency Departments, Intensive Care units, Aged Care, Hospital In The Home, and COVID Wards completed a cross-sectional survey consisting of the Kessler 6 item (Psychological Distress), Personal Wellbeing Index (Subjective Wellbeing), Coronavirus Health Impact Survey tool (COVID-19 related factors) and occupational factors. Multivariable linear regressions were used to evaluate unadjusted and adjusted associations. Relative weight analysis was used to compare and identify key predictors.ResultsOut of 167 participants, 18.1% screened positive for a probable mental illness and a further 15.3% screened positive for low wellbeing. Key risk factors for greater psychological distress included COVID infection worries, relationship stress and younger age. For both psychological distress and lower wellbeing, health status and supervisor support were key protective factors, while infection risks were key risk factors. Only positive changes in relationship quality was protective of lower wellbeing.ConclusionThis study highlights the significance of social determinants and individual level factors alongside work related factors, in influencing FHWs’ mental health and wellbeing during public health crises, such as the COVID-19 pandemic. Findings suggest that future interventions and supports should take a more holistic approach that considers work, social and individual level factors when supporting FHWs’ mental health and wellbeing.
Money talks: performance-based reimbursement systems impact on perceived work, health and patient care for physicians in Sweden
Authors: Brulin Emma , Ekberg Kerstin , Landstad Bodil J. , Lidwall Ulrik , Sjöström Malin , Wilczek Alexander 
Published: July 2023

IntroductionThe study aimed to investigate in which way performance-based reimbursement (PBR) systems in Swedish healthcare services (1) subjectively impacted physicians’ work and patient care and (2) were associated with the occurrence of stress-induced exhaustion disorders among physicians.MethodThe study applied a mixed-method design. Data were collected from a representative sample of Swedish physicians. In the questionnaire, respondents were asked to answer an open-ended question regarding their reflections on PBR. The answers to the open-ended question were analysed using thematic analysis. Respondents were also asked to rate the impact of PBR on their work. The association between PBR and self-rated stress-induced exhaustion disease was analysed with logistic regressions. Stress-induced exhaustion disorder was measured using the Burnout Assessment Scale.ResultsThematic analysis resulted in four themes: (1) Money talks, (2) Patients are affected, (3) Medical morals are challenged, and (4) PBR increase the quantity of illegitimate tasks. Logistic regressions showed that physicians who experienced PBR had an impact on their work and had a two-fold higher risk of stress-induced exhaustion disorder.DiscussionOur findings suggest that current reimbursement systems in Sweden play an essential role in Swedish healthcare and negatively influence physicians’ work and health. Also, current PBR impact patients negatively. No previous study has explored the potentially harmful impact of PBR on how physicians perceive work, health and patient care. Results indicate that policymakers should be encouraged to deeply review PBR systems and focus on ways that they can limit the negative impact on physicians’ work and health while meeting future challenges.
Healthcare-associated adverse events and readmission to the emergency departments within seven days after a first consultation
Authors: Gasperini Guillaume , Bouazzi Leila , Sanchez Antoine , Marotte Louis , Kézachian Laury , Bellec Guillaume , Cazes Nicolas , Rosetti Maxime , Bousquet Claire , Renard Aurélien , Sanchez Stéphane 
Published: July 2023

IntroductionThe use of emergency hospital service has become increasingly frequent with a rise of approximately 3.6%. in annual emergency department visits. The objective of this study was to describe the reasons for reconsultations to emergency departments and to identify the risk and protective factors of reconsultations linked to healthcare-associated adverse events.Materials and methodsA retrospective, descriptive, multicenter study was performed in the emergency department of Troyes Hospital and the Sainte Anne Army Training Hospital in Toulon, France from January 1 to December 31, 2019. Patients over 18 years of age who returned to the emergency department for a reconsultation within 7 days were included. Healthcare-associated adverse events in the univariate analysis (p &lt; 0.10) were introduced into a multivariate logistic regression model. Model performance was examined using the Hosmer-Lemeshow test and calculated with c-statistic.ResultsWeekend visits and performing radiology examinations were risk factors linked to healthcare associated adverse events. Biological examinations and the opinion of a specialist were protective factors.DiscussionNumerous studies have reported that a first consultation occurring on a weekend is a reconsultation risk factor for healthcare-associated adverse events, however, performing radiology examinations were subjected to confusion bias. Patients having radiology examinations due to trauma-related pathologies were more apt for a reconsultation.ConclusionOur study supports the need for better emergency departments access to biological examinations and specialist second medical opinions. An appropriate patient to doctor ratio in hospital emergency departments may be necessary at all times.
Effect of built environment on BMI of older adults in regions of different socio-economic statuses
Authors: Zang Peng , Chen Kaihan , Zhang Haifan , Qiu Hualong , Yu Yun , Huang Jianwen 
Published: July 2023

BackgroundNumerous studies have ignored the influence of underdeveloped urban surroundings on the physical health of China’s ageing population. Lanzhou is a typical representative of a less developed city in China.MethodsThis study investigated the relationship between body mass index (BMI) and built environment amongst older adults in regions of different socio-economic statuses (SES) using data from medical examinations of older adults in Lanzhou, as well as calculating community built environment indicators for regions of different SES based on multiple linear regression models.ResultsResults showed that age and underlying disease were negatively associated with overall older adult BMI in the study buffer zone. Land use mix, number of parks and streetscape greenery were positively associated with older adult BMI. Street design and distance to bus stops were negatively connected in low SES regions, but population density and street design were negatively correlated in high SES areas.ConclusionThese findings indicate that the built environment of SES regions has varying impacts on the BMI of older persons and that planners may establish strategies to lower the incidence of obesity amongst older adults in different SES locations.
Doping in Paralympic sport: perceptions, responsibility and anti-doping education experiences from the perspective of Paralympic athletes and parasport coaches
Authors: Blank Cornelia , Weber Kathrin , Boardley Ian D. , Abel Thomas , Schobersberger Wolfgang , Patterson Laurie B. 
Published: July 2023

IntroductionLimited effort has been invested in understanding doping in Paralympic sport. The limited evidence that exists suggests that factors influencing doping in parasport are similar to Olympic sport. However, based on the design and nature of the previous studies, where methods have been mostly limited to qualitative data and prevalence numbers, further research is warranted to extend previous findings.MethodsInformed by current evidence from Paralympic and Olympic sport, we aimed to investigate (1) para-athletes' perceptions of Anti-Doping Rule Violations (ADRVs) and responsibility for them, (2) descriptive norms for doping in parasport (3) perceptions of anti-doping education and legitimacy of anti-doping authorities, and (4) coach engagement in doping prevention and levels of doping confrontation efficacy using a quantitative survey approach.ResultsIn total, valid survey responses from 126 Paralympic athletes and 35 coaches from four countries (Germany, Austria, Switzerland, UK) were analysed for experience with anti-doping, descriptive norms, anti-doping education, perceived legitimacy, knowledge, and doping confrontation efficacy (coaches only). Across both athletes and coaches, the level of education was generally good and doping willingness was low. Classification cheating was considered a form of doping and seems to be an important issue for athletes and coaches, especially within the UK sample. For 33.3% of the athletes, doping control was their first experience with anti-doping. Coaches' engagement with doping prevention activities and their perceived efficacy to confront doping-related matters appears to be higher compared to Olympic coaches' samples.DiscussionSport organisations/NADOs in Paralympic sport could use synergies with those organisations in Olympic sport, adopting similar approaches to anti-doping education, also focusing on a balanced communication of doping prevalence numbers and testing figures. Efforts to ensure athletes are educated about anti-doping before they are tested should be upheld. It seems that in para sport, different compared to able-bodied coaches, anti-doping organizations do not have to convince the coaches about their roles (i.e., being responsible for anti-doping education) anymore but can directly build on these resources. Overall, it seems that there are few differences between parasport and able-bodied sports and thus responsible organisations could use the existing programmes in Olympic sport and only adapt special content (e.g., boosting) which is unique to Paralympic athletes.
Population Dynamics and Feeding Preferences of Three Bacterial-Feeding Nematodes on Different Bacteria Species
Authors: Zhou Yiqun , Zheng Hao , Gao Dandan , Zhao Jie 
Published: July 2023

Soil food webs are extremely complex as they contain diverse organisms. Feeding preference, also known as prey selection, is an important determinant of soil community compositions. However, the feeding preferences of nematodes are commonly ignored in ecology research. In this paper, the population dynamics and feeding preferences of three bacterial-feeding nematodes (i.e., Caenorhabditis elegans, Protorhabditis spp., and Acrobeloides spp.) for eight bacterial prey species were evaluated. Protorhabditis and Acrobeloides were isolated from a paddy soil in subtropical China. C. elegans, the most common model system for biological research, was used as a control in this study, and it was revealed that C. elegans could feed on all the eight bacteria strains. Protorhabditis could only survive when fed E. coli and Bacillus thuringiensis. Acrobeloides could only survive when fed E. coli and B. aryabhattai. During 10 days of culture, C. elegans populations reached the maximum in 5–7 days, and most C. elegans populations exceeded 10,000 individuals. The two Protorhabditis populations on E. coli and Bacillus thuringiensis included less than 800 individuals during 10 days of culture. Acrobeloides population on B. aryabhattai reached the maximum (7799 individuals) on day 8, while on E. coli was its population included less than 500 individuals. These results indicate that different nematode species indeed have distinct feeding preferences. In addition, the population dynamics of the two soil nematodes isolated from soil could not fully match with their inferred life-history strategies (i.e., cp values, and a 1-5 colonizer-p-ersister series that range from r-strategists to K-strategists). Our findings highlights the existing deficiencies in the understanding of the feeding behavior and the life-history strategies of soil nematodes.
Natural Hybridization between Bursera bicolor × B. glabrifolia (Burseraceae) Complex: Molecular and Chemical Evidence
Authors: Ocampo-Bautista Fidel , Mussali-Galante Patricia , Alvarez Laura , Marquina-Bahena Silvia , Valencia-Cuevas Leticia , Valencia-A Susana , Tovar-Sánchez Efraín 
Published: July 2023

The hybridization phenomenon is recognized as an important evolutionary force that influences the diversification and evolution of different vascular plant groups. Hence, it is important to identify hybrid individuals. In Mexico, the dry tropical forest (DTF) is considered as the main center of diversification and endemism of the Bursera genus, containing 85% of the approximately 106 described species worldwide. In the Mexican DTF, a complex of Bursera species was identified, which is formed by two putative parental species Bursera bicolor (Will. ex Schltdl.) Engl. and B. glabrifolia (H.B.K) Engl. Their putative hybrids were analyzed using molecular (cpSSR) and chemical markers (monoterpenes, sesquiterpenes, and triterpenes) in two pure sites (one site for each parental species) and two hybrid zones. We tested whether individuals with atypical morphology between B. bicolor and B. glabrifolia from sympatric sites were the result of genetic flow between these two species. A total of 80 individuals were analyzed with 4 microsatellite diagnostic primers and 37 secondary metabolites (SMs). The genetic and chemical markers were highly coincident according to the statistical analyses performed, and they supported the hybridization hypothesis in this Bursera complex, with both species remaining distinct even in sympatric zones. α-Amyrin (b), β-amyrin (a), and β-amyrin (b) (triterpenes) were the SMs that most contributed to differentiating putative parental species according to SIMPER analysis. The putative hybrids registered the highest genetic diversity values along with the highest number of SMs, out of which 11 were novel and distributed as follows: triterpenes > monoterpenes > sesquiterpenes. Finally, the chemical markers of the three analyzed families give a framework for future studies to explore hybridization events between Bursera species.
Thermophilic Dark Fermentation for Simultaneous Mixed Volatile Fatty Acids and Biohydrogen Production from Food Waste
Authors: Jariyaboon Rattana , Hayeeyunu Surananee , Usmanbaha Nikannapas , Ismail Shahrul Bin , O-Thong Sompong , Mamimin Chonticha , Kongjan Prawit 
Published: July 2023

Food waste is categorized as organic solid waste, which has a negative impact on environmental sustainability. Food waste was simultaneously used for the feasible generation of mixed volatile fatty acids (VFAs) and bio-hydrogen by deploying dark fermentation. Original anaerobic digested sludge was prepared via the shock technique with 50 g/L glucose under thermophilic temperature (55 °C). The pretreated inoculum was found capable of converting 10 g VS/L food waste to hydrogen with a rather high yield of 135.2 ± 7 mL H2/VSadded. The effect of various concentrations of food waste, including 10.2, 16.3, 20.3, and 26.4 g VS/L, on mixed VFAs production was subsequently carried out in batch dark fermentation. The highest butyric acid concentration (5.26 ± 0.22 g/L) in soluble metabolites was obtained from batch dark fermentation with 26.4 g VS/L of food waste. The dominant Clostridium thermobutyricum, Clostridium sporogenes, and Octadecobacter sp. found in the batch of dark fermentation of food waste could confirm the effectiveness of the load shock pretreatment method for inoculum preparation. The continuous stirred tank reactor (CSTR) inoculated with mixed cultures, also prepared via the load shock pretreatment method and without the addition of external nutrients, was operated by feeding 26.4 g VS/L food waste at the kinetically designed HRT for 4 days, corresponding to an organic loading rate (OLR) of 7.6 g VS/L·d. Under steady state conditions, promising butyric acid (5.65 ± 0.51 g/L)-rich mixed VFAs were achieved along with the hydrogen yield of 104.9 ± 11.0 mL-H2/g VSadded, which is similar to the upper side of the previously reported yields (8.8 ± 0.6–103.6 ± 0.6 mL-H2/g VS).
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells
Authors: Vishwanath Divakar , Xi Zhang , Ravish Akshay , Mohan Arunkumar , Basappa Shreeja , Krishnamurthy Niranjan Pattehalli , Gaonkar Santosh L. , Pandey Vijay , Lobie Peter E. , Basappa Basappa 
Published: July 2023

Histone deacetylases (HDACs) are an attractive drug target for the treatment of human breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical and clinical studies. The need to understand the scope of the mode of action of HDACis, as well as the report of the co-crystal structure of HDAC6/SS-208 at the catalytic site, provoked us to develop an isoxazole-based lead structure called 4-(2-(((1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) pyrimidin-4-yl) morpholine (5h) and 1-(2-(((3-(p-tolyl) isoxazol-5-yl)methyl)thio) pyrimidin-4-yl) piperidin-4-one (6l) that targets HDACs in human BC cells. We found that the compound 5h or 6l could inhibit the proliferation of BC cells with an IC50 value of 8.754 and 11.71 µM, respectively. Our detailed in silico analysis showed that 5h or 6l compounds could target HDAC in MCF-7 cells. In conclusion, we identified a new structure bearing triazole, isoxazole, and thiouracil moiety, which could target HDAC in MCF-7 cells and serve as a base to make new drugs against cancer.
PERANCANGAN TERMINAL BUS TIPE A KLARI KABUPATEN KARAWANG
Authors: Tresna Ruchant Bayu , Aditya Nova Chandra 
Published: July 2023

Perkembangan kota Karawang sebagai kota industri berakibat pada banyaknya pendatang yang ingin bekerja di kota ini. Hal ini berimbas pada kebutuhan moda transportasi salah satunya bus karena bus merupakan moda transportasi yang terjangkau. Terminal utama Klari, Kabupaten Karawang tidak sanggup menampung jumlah bus tersebut, karena terminal Klari tersebut merupakan terminal tipe C. Paper ini merupakan usulan desain berupa terminal tipe A di Karawang. Metoda pendekatan perancangan adalah prinsip penerapan konsep wayfinding terhadap desain terminal Klari. Hasil dari penerapan prinsip konsep wayfinding yaitu: memiliki prinsip Aksesibel, Sosiabel, Connecting, dan Welcoming merupakan penerapan yang dapat dilihat pada hasil desain rancangan.
Marcos históricos e dispositivos legais para a inclusão das pessoas idosas em uma sociedade em transformação
Authors: Silva de Souza Janaína , Mariani Braz Ruth Maria 
Published: July 2023

Apresentamos um levantamento dos marcos históricos e legais acerca do envelhecimento populacional a fim de analisarmos como estão sendo garantidos os direitos da pessoa idosa na sociedade brasileira. Utilizamos como critério metodológico a pesquisa documental em sites oficiais de instituições internacionais: Organização das Nações Unidas, Organização Pan-americana de Saúde e nacionais: Presidência da República do Brasil, Senado Federal, Ministério da Saúde, Ministério da Previdência e Assistência social, Instituto Brasileiro de Geografia e Estatística, bem como a análise de dados oriundos de bases científicas. A pesquisa nas bases científicas foi realizada por meio de strings de busca utilizando as palavras: políticas públicas, saúde, educação, cidadania, os operadores and e or. Com os resultados, constatamos que apesar de nossa sociedade dispor de significativa instrumentalização legal, com base em tratados internacionais, em prol dos direitos das pessoas idosas, faz-se, no entanto, necessária mais participação e controle social para que as conquistas legais sejam efetivadas, visto que as políticas públicas existentes para garantir o cumprimento dos direitos já conquistados mostraram-se ainda insuficientes.
Palavras-chave: Políticas públicas. Efetivação de direitos. Envelhecer. Inclusão. Meta pesquisa
Characterization of perovskite films prepared with different PbI2 deposition rates
Authors: Iida Tamio , Okada Gota , Takase Kento 
Published: July 2023

Abstract
The perovskite (CH3NH3PbI3) films prepared using PbI2 film deposited at controlled deposition rates were evaluated. In this process, PbI2 films were deposited by vacuum evaporation process and then converted into CH3NH3PbI3 films by annealing in methylammonium iodide vapor. The grain size of CH3NH3PbI3 films were successfully tuned from 90 to 125 nm by controlling the PbI2 deposition rate from 0.025 to 0.4 nm s−1. Furthermore, by using the controlled CH3NH3PbI3 film as the light harvesting layer, inverted planar perovskite solar cells were fabricated, and the improvement in power conversion efficiency was confirmed.