bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Temperature Stress During Reproductive Stages: Impacts and Traits Associated with Seed Set
Authors: Kishanth Kanna Venkatesan , Djanaguiraman Maduraimuthu , Jincy Mony , Ananthi Krishnan , Senthil Alagarswamy , Sathya Moorthy Pon , Iyanar Krishnamoorthy , Shafi Sadiah , Sofi Parvaze A. 
Published: February 2025

Abstract
High temperature (HT) stress negatively influences reproductive phases in field crops, and the effects are critical to understand in the present and future climate. This review focuses on research on grain crops (rice, wheat, sorghum, pearl millet, soybean and groundnut) with the goals of identifying (i) the sensitivity of reproductive stages during crop development under HT stress and (ii) the metabolic changes caused by HT on the reproductive tissue. Reproductive stages are the most sensitive stages in plants to stress, particularly flowering and gametogenesis, and which results in a reduction in seed numbers due to fertility loss, improper fertilization, and reduction in seed‐set percentage. Most of the field crops are sensitive to a temperature of >35 °C during the reproductive growth stages, and this threshold varies among the species and genotypes. Abortion of micro‐ and/or mega‐spores, premature tapetal cell degradation, loss of gamete viability, anther indehiscence, a lower pollen grain germination rate on the stigma, loss of pollen germination, stigma receptivity, pollen tube tip polarity, pollen tube growth signals, and embryo abortion are the physiological processes affected by HT stress. The major changes in the gametes lead to alteration in carbohydrate metabolism and transport, loss of viability, elevated reactive oxygen species production, increased membrane phospholipid saturation level and decreased phosphatidic acid level. Molecular and biochemical tools help to screen and identify the sources of tolerance. Developing crop tolerance to high‐temperature stress is possible through continued collaboration among biologists, breeders, and agronomists without affecting the crop grain yields.
The implications of the American Board of Radiology's decision to relinquish its specialty board designation on prospective authorized medical physicists (AMPs) and radiation safety officers (RSOs)
Authors: Tien Christopher J. , Simiele Samantha J. , Prisciandaro Joann I. , Zoberi Jacqueline E. , Huang Y. Jessica , Hinchcliffe William A. , Al‐Hallaq Hania A. 
Published: February 2025

AbstractIn order to independently supervise the medical use of byproduct material, physicists in the United States (US) must legally meet the qualifications defined by the Nuclear Regulatory Commission (NRC) in the 35th part of the tenth title of the Code of Federal Regulations (§ 10 CFR Part 35). The American Board of Radiology (ABR) relinquished its NRC‐recognized specialty board (NSB) status at the end of 2023, which eliminated the NSB application pathway for those who earn ABR certification in 2024 and beyond. While these changes in NSB status are not retroactive and will not affect eligibility for diplomates who already possess certificates, these changes will nonetheless have repercussions for those individuals who regularly provide training and experience (T&E) attestations to the NRC, such as residency program directors, brachytherapy rotation preceptors, or radiation safety officers. This article will focus on the repercussions for new authorized medical physicist and radiation safety officer applicants with ABR certificates to be conferred in 2024 and later.
Efficient Organic Light‐Emitting Diodes Based on Ambipolar Doped Organic Single Crystals of Bis‐Styrylbenzene Derivatives
Authors: Liu Ze‐Qing , Li Su‐Heng , Ye Gao‐Da , Du Yuhan , Feng Yu , Zhang Hu , Qu Lei , Wang Nai‐Qi , Hao He , Sun Lingjie , Yang Fangxu , Liu Yue‐Feng , Ding Ran , Liu Yu , Feng Jing 
Published: February 2025

AbstractAmbipolar carrier transport in organic single crystals is essential to maximize exciton recombination and thus achieve high‐efficiency organic light‐emitting diodes (OLEDs). Herein, two bis‐styrylbenzene derivatives, 1,4‐bis(4‐methylstyryl)benzene (3PV‐Me) and 1,4‐bis(4‐trifluoromethylstyryl)benzene (3PV‐CF3), are introduced into the construction of ambipolar 3PV‐CF3 doped 3PV‐Me (3PV‐Me‐CF3) single crystals. The same molecular skeleton of these two molecules endow them with similar molecular shapes and sublimation temperatures. Doping with 3PV‐CF3 dopants is evaluated for their effect on the photophysical properties of host 3PV‐Me crystal. Systematic spectroscopic investigations and high‐resolution time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) depth profiling are further conducted to gain a deep insight into the doping details of 3PV‐Me‐CF3 single crystals. Furthermore, their ambipolar carrier transport behavior is evaluated by the space‐charge‐limited current (SCLC) method, exhibiting nearly equal hole and electron mobilities. These ambipolar 3PV‐Me‐CF3 single crystals are then utilized for the fabrication of single‐crystal OLEDs, which demonstrated an almost sixfold enhancement in the electroluminescence (EL) efficiency in comparison to the unipolar 3PV‐Me single‐crystal OLEDs. The findings reveal the great potential of well‐balanced ambipolar organic single‐crystalline semiconductors for the development of high‐performance single‐crystal optoelectronic devices.
Ruptured abdominal aortic aneurysm managed using resuscitative endovascular balloon occlusion of the aorta with a two‐stage approach
Authors: Ishida Kenichiro , Matsumura Yosuke , Kitabayashi Kai , Ogawa Haruka , Tajiri Masashi , Ochi Koichi , Iehara Takashi , Nakagawa Masaya , Shirasaki Yukie , Nishi Hiroyuki , Ohnishi Mitsuo 
Published: February 2025

AbstractBackgroundA ruptured abdominal aortic aneurysm (rAAA) is fatal. While Resuscitative endovascular balloon occlusion of the aorta (REBOA) contributes to hemodynamic stability, organ ischemia should be carefully considered.Case PresentationA 69‐year‐old obese man with untreated hypertension presented with sudden back pain and hypotension. Computed tomography confirmed the presence of an rAAA. REBOA was initially planned in Zone 1 via the left brachial artery but was eventually switched to Zone 3 via the right femoral artery. Hemodynamic stability was achieved through blood transfusion and partial REBOA, followed by surgical intervention. The postoperative recovery was uneventful.ConclusionZone 1 REBOA via the left brachial approach provided safe aortic occlusion. Transitioning to Zone 3 REBOA, combined with meticulous organ perfusion management and blood transfusion, prevented ischemia–reperfusion complications.
Heart Rate Variability as a Digital Biomarker in Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation
Authors: Taylor Mallory R. , Bradford Miranda C. , Zhou Chuan , Fladeboe Kaitlyn M. , Wittig Jorie F. , Baker K. Scott , Yi‐Frazier Joyce P. , Rosenberg Abby R. 
Published: February 2025

ABSTRACTIntroductionAdolescents and young adults (AYAs) receiving hematopoietic cell transplantation (HCT) are at high risk for poor psychosocial outcomes. Heart rate variability (HRV), a surrogate for autonomic nervous system activity, is a promising digital biomarker that has been linked to important outcomes. The objectives of this study were to prospectively describe the trajectory of HRV among AYAs receiving HCT and explore the association between HRV and patient‐reported outcomes (PROs).MethodsThis was a multi‐site study embedded in a randomized trial among AYAs receiving HCT (NCT03640325). We collected sequential 24‐h HRV metrics, including the standard deviation of normal‐to‐normal beats (SDNN), root‐mean‐square of successive differences (RMSSD), as well as frequency domain measures. PRO surveys queried anxiety, depression, quality of life, hope, and resilience at baseline and 3 months. We summarized outcomes using descriptive statistics, and Pearson correlation coefficients were used to examine the relationship between HRV and PROs.ResultsThirty‐nine HRV recordings were collected from n = 16 participants aged 12–21 years. There was a moderately strong correlation between inferior baseline HRV and higher anxiety and depression (anxiety: r = −0.35 (p = 0.18) for SDNN, r = −0.47 (p = 0.07) for RMSSD; depression: r = −0.26 (p = 0.34) for SDNN, r = −0.39 (p = 0.14) for RMSSD). Among participants with elevated baseline anxiety, higher HRV suggested greater improvement in anxiety over time (r = −0.66 (p = 0.08) for SDNN, r = −0.31 (p = 0.45) for RMSSD).ConclusionsThere was a correlation between HRV and PROs in this study, and among those with elevated anxiety, HRV predicted improvement over time. Digital biomarkers may augment behavioral intervention design and implementation.
Cannabinoid Receptor Type 2 Agonist, GW405833, Reduced the Impacts of MDA‐MB‐231 Breast Cancer Cells on Bone Cells
Authors: Inson Ingon , Chutoe Chartinun , Kanjanapipak Janjira , Lertsuwan Kornkamon 
Published: February 2025

ABSTRACTAimBreast cancer frequently metastasizes to bones. The interaction between breast cancer cells and bone cells results in osteolytic lesions by disrupting the balance between osteoblast‐mediated bone production and osteoclast‐mediated bone resorption. This study aims to investigate the effects of the cannabinoid receptor type 2 (CB2) agonist, GW405833, on interactions between breast cancer cells and osteoblasts as well as its impact on breast cancer‐induced osteoclastogenesis.Materials & MethodsMDA‐MB‐231, UMR‐106, RAW 264.7 cells were used to represent breast cancer cells, osteoblast‐like cells and macrophage‐osteoclast precursor cells, respectively. Cell viability was evaluated by MTT assay, and breast cancer cell invasion was assessed by Transwell invasion assay. Tartrate‐resistant acid phosphatase (TRAP) staining was utilized to evaluate osteoclastogenesis.ResultsOur results demonstrated that GW405833 disrupted MDA‐MB‐231‐induced UMR‐106 cell death and promoted UMR‐106 cell viability. The underlying mechanism of these effects was determined in this study. GW405833 reduced AKT phosphorylation in MDA‐MB‐231 cells without affecting mTOR protein expression or its phosphorylation. Conversely, in UMR‐106 cells, GW405833 induced AKT and mTOR phosphorylated protein. Furthermore, the mTOR inhibitor reversed the GW405833‐induced recovery of UMR‐106 cell viability under MDA‐MB‐231‐derived conditioned media (CM) exposure. These findings underscore the critical role of the AKT/mTOR pathway in mediating GW405833's inhibitory effects on cancer‐bone interactions. Additionally, GW405833 suppressed osteoblast‐enhanced breast cancer cell invasion and the expression of invasion‐related proteins in both cell types, along with reducing osteoclastogenic factors induced by MDA‐MB‐231 CM in UMR‐106 cells and suppressing MDA‐MB‐231 CM‐enhanced osteoclastogenesis in RAW 264.7 cells.ConclusionThis study highlights the therapeutic potential of cannabinoid receptor agonist for treating breast cancer bone metastasis and bone‐related complications.
Global myocardial work index predicts response to biventricular pacing in patients with non‐left bundle branch block
Authors: Kondo Shun , Inden Yasuya , Yanagisawa Satoshi , Miyamae Kiichi , Miyazawa Hiroyuki , Goto Takayuki , Tachi Masaya , Iwawaki Tomoya , Yamauchi Ryota , Hiramatsu Kei , Shimojo Masafumi , Tsuji Yukiomi , Murohara Toyoaki 
Published: February 2025

AbstractAimsCardiac resynchronization therapy (CRT) improves the prognosis of patients with heart failure (HF) and wide QRS complex. However, patients with non‐left bundle branch block (LBBB) show a poor response to CRT. This study evaluated myocardial work estimated by pressure–strain loops on echocardiography for predicting response to CRT in patients with non‐LBBB.Methods and resultsOf 267 patients who underwent CRT implantation, 54 patients with non‐LBBB (mean age, 62 ± 12 years, 72% males, and 24% with ischemic cardiomyopathy) were retrospectively included. Two‐dimensional speckle‐tracking echocardiography was performed before and at 6‐month follow‐up in all patients. Myocardial work was estimated by pressure–strain loop analysis using speckle‐tracking echocardiography and non‐invasive blood pressure measurement. CRT response was defined as a ≥15% decrease in left ventricular end‐systolic volume on echocardiography at the 6‐month follow‐up. The mean left ventricular ejection fraction (LVEF) before implantation was 27% ± 8% in total. Six months after implantation, 18 patients (33%) responded to CRT. The absolute LVEF improvement for responders and non‐responders were 5.5% ± 6.9% and 1.3% ± 7.5%, respectively (P = 0.021). Baseline global work index (GWI), which is the average myocardial work based on the pressure–strain loop, was significantly higher in the responder group than in the non‐responder group (590 ± 271 vs. 409 ± 216 mmHg%; P = 0.010). Multivariable analysis showed GWI to be an independent predictor of CRT response (odds ratio, 1.109; 95% confidence interval [CI], 1.013–1.213; P = 0.024). Receiver operating characteristic curve analysis determined the cut‐off value of GWI for response as 456 mmHg% (AUC 0.700, 95% CI 0.553–0.840; P = 0.019). During the median 37‐month follow‐up, all‐cause death occurred in 21 patients (39%). On multivariable analysis, GWI ≤ 456 mmHg% was independently associated with an increased risk of all‐cause mortality (hazard ratio, 2.882; 95% CI, 1.157–7.176; P = 0.023).ConclusionsHigh GWI assessed by speckle‐tracking echocardiography and a non‐invasively estimated LV pressure curve was independently associated with a favourable response to CRT and improved outcomes in patients with non‐LBBB. The use of this non‐invasive approach for quantifying myocardial variability and residual contractility can be beneficial for assessing CRT candidates and allow for more accurate patient stratification. Further, large multicentre studies are required to validate these findings.
Exploration of 3D Coal Seam Geological Modeling Visualization and Gas Content Prediction Technology Based on Borehole Data
Authors: Zhao Xiangfeng , Hao Tianxuan , Feng Huiyan , Li Fan , Li Xu 
Published: February 2025

ABSTRACTThe geological structure of coal mines and the precise prediction of coal seam gas content are key factors in creating the transparent working face, and they also represent an important aspect of intelligent coal mining. The traditional technology of coal seam geological construction and gas content prediction is not advanced. This paper presents a methodology for 3D implicit geological modeling and visualization using Gempy and PyVista libraries, as well as gas prediction and distribution based on the Scikit‐learn library, all of which are underpinned by machine learning techniques. Under this method, the geological modeling of coal seam was converted to the kriging interpolation algorithm based on machine learning of coal seam thickness data. The problem of coal seam gas content is converted into a regression prediction problem of coal seam characteristic values and gas content target values based on machine learning. The pykrige package under Python is used to interpolate the obtained coal seam thickness. Based on the linear regression prediction model, loss function and other prediction methods and algorithms, the accurate prediction of coal seam gas content based on borehole data is realized. Under the above various operations, a 3D geological model of the mine and the gas content distribution map of the coal seam are finally obtained. Compared to actual borehole data and gas geological maps, this method offers high precision and enhanced efficiency.
Infraslow Dynamic Patterns in Human Cortical Networks Track a Spectrum of External to Internal Attention
Authors: Watters Harrison , Davis Aleah , Fazili Abia , Daley Lauren , LaGrow T. J. , Schumacher Eric H. , Keilholz Shella 
Published: February 2025

ABSTRACTEarly efforts to understand the human cerebral cortex focused on localization of function, assigning functional roles to specific brain regions. More recent evidence depicts the cortex as a dynamic system, organized into flexible networks with patterns of spatiotemporal activity corresponding to attentional demands. In functional MRI (fMRI), dynamic analysis of such spatiotemporal patterns is highly promising for providing non‐invasive biomarkers of neurodegenerative diseases and neural disorders. However, there is no established neurotypical spectrum to interpret the burgeoning literature of dynamic functional connectivity from fMRI across attentional states. In the present study, we apply dynamic analysis of network‐scale spatiotemporal patterns in a range of fMRI datasets across numerous tasks including a left–right moving dot task, visual working memory tasks, congruence tasks, multiple resting state datasets, mindfulness meditators, and subjects watching TV. We find that cortical networks show shifts in dynamic functional connectivity across a spectrum that tracks the level of external to internal attention demanded by these tasks. Dynamics of networks often grouped into a single task positive network show divergent responses along this axis of attention, consistent with evidence that definitions of a single task positive network are misleading. Additionally, somatosensory and visual networks exhibit strong phase shifting along this spectrum of attention. Results were robust on a group and individual level, further establishing network dynamics as a potential individual biomarker. To our knowledge, this represents the first study of its kind to generate a spectrum of dynamic network relationships across such an axis of attention.
Exploring the Potential for Graphic Warning Labels to Reduce Intentions to Consume Energy Drinks
Authors: Zhu Xiaole , Miller Caroline , Roberts Rachel , Ettridge Kerry 
Published: February 2025

ABSTRACTIssue AddressedEffective interventions to reduce energy drink (ED) consumption are needed. This study explored the effect of warning labels on intentions to reduce ED consumption, perceived label effectiveness and protection motivation theory (PMT) constructs.MethodsAustralian ED consumers aged 18 to 39 years (N = 343) participated in an experimental online survey, randomly assigned to view one of three ED warning label conditions (weight gain, cardiac effects, no label—control). Intentions to reduce ED consumption, perceived effectiveness of labels and selected PMT constructs were assessed.ResultsParticipants reported moderate‐high awareness of the health effects of consumption (62.68%) and advisory statements on EDs (69.39%), including daily consumption limits (48.40%). EDs were consumed frequently, with 56.26% regular (at least weekly) consumers and most commonly for functional benefits (e.g., alertness). ED warning labels did not have a statistically significant effect on intentions to reduce consumption. The cardiac label performed better than the weight gain label in ‘grabbed attention’ (72.97% vs. 55.66%, p = 0.008), with non‐significant trends (p > 0.05, absolute differences ≥ 10%) suggesting it was stronger on some other perceived effectiveness measures. Supplementary analyses indicated females in the cardiac condition reported greater intentions to reduce ED consumption than females in the control condition (p = 0.042).ConclusionsGraphic warning labels and labels warning of cardiac effects are worthy of further exploration as a potential intervention to reduce ED consumption.So What?Future research should explore the motivations underlying ED consumption and further explore messages that will resonate with consumers.
Emerging Irrigation and Drainage Technologies: A Bibliometric Review of the Journal Irrigation and Drainage From 2010 to 2024
Authors: Li Jiusheng , Wang Zhen 
Published: February 2025

ABSTRACTIrrigation and Drainage (IRD) is a prestigious peer‐reviewed journal with an international reputation and publishes technical papers on all scientific, engineering, environmental and socio‐economic issues associated with irrigation, drainage and flood management. During the past 15 years from 2010 to 2024, 1517 papers were published in the journal. We analysed all these articles using bibliometric techniques to examine the impact of the journal's publications, the most productive and influential authors, and their contributions to the field of irrigation, drainage and flood management. Co‐authorship among the top authors, co‐occurrences of the topics, cocitations of the journals, bibliographic coupling of the authors and affiliated institutes and countries were analysed by applying network analysis techniques via VOSviewer software. The advancements in research during the last 15 years are also critically highlighted to understand recent developments in the field of irrigation, drainage and flood management. Future directions are also proposed in this review and might provide guidance for future research on irrigation, drainage and flood management.
Clinician perspectives on electronic health record behavioral alerts and hospital workplace violence prevention: A mixed methods study at 20 organizations
Authors: Weerahandi Himali , Burden Marisha , Kopp Zoë , Callister Catherine , Burke Jamie , Dayton Khooshbu , Keniston Angela , Ledford Russell , Raffel Katie E. , Schnipper Jeffrey , Auerbach Andrew 
Published: February 2025

AbstractBackgroundWorkplace violence prevention programs are important for safety, but little is known about how they are perceived by clinicians or whether electronic health record (EHR) behavioral alerts are perceived as effective.ObjectiveTo understand perspectives on the use of EHR behavioral alerts as part of workplace violence prevention programs in hospitals.MethodsMixed methods study utilizing semi‐structured focus groups with a structured survey. Focus group participants were members of a national hopsitalist consortium.ResultsTwenty‐eight individuals from 20 different organizations participated in focus groups, with 24 (86%) completing the survey. There was broad uncertainty in best practices for inpatient workplace violence prevention. There was also wide variation in EHR behavioral alert use across multiple domains, including how and why the alerts are placed and how they are used by the end user. Finally, focus groups had mixed sentiments on the potential impacts of these alerts; among participants who responded to surveys, half (50%) noted that alerts caused deviations in care and 21% indicated they witnessed instances where behavioral alerts led to adverse patient outcomes. Most (67%) survey respondents did not think EHR behavioral alerts prevented workplace violence. The majority (88%) of respondents also reported that patient demographic factors impacted whether an alert was placed.LimitationsThe study focused on clinician experience at academic hospitals.Conclusions and RelevanceReports of uncertainty in best practices for deploying EHR behavioral alerts, along with perceptions of variability in implementation and potential biases in alert usage, raise concerns about their effectiveness and potential for worsening disparities. Standardized, evidence‐based practices that safeguard healthcare workers without compromising patient care and equity are needed.
New Lower Bound for the Radius of Analyticity for the Modified 2D Zakharov–Kuznetsov Equation
Authors: Getachew Tegegne 
Published: February 2025

ABSTRACTWe consider the initial value problem associated to the 2D modified Zakharov‐Kuznetsov equation. For a class of initial data that is real analytic in a strip around the axis of the complex plane that have a fixed radius of spatial analyticity , we show that the uniform radius of spatial analyticity of solutions at time is bounded from below by as the time goes to infinity. This improves very recent works. Our strategy mainly relies on an almost conservation law in a modified Gevrey spaces, local smoothing estimates, maximal function estimates, Strichartz estimates, and Sobolev embedding.