bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parametric Postprocessing of Dual-Resolution Precipitation Forecasts
Authors: Szabó Marianna , Gascón Estíbaliz , Baran Sándor 
Published: May 2023

Abstract
All major weather centers issue ensemble forecasts, which differ both in ensemble size and spatial resolution, even while covering the same domain. These parameters directly determine both the forecast skill of the prediction and the computation cost. In the past few years, the plans for upgrading the configuration of the Integrated Forecast System of the European Centre for Medium-Range Weather Forecasts (ECMWF) from a single forecast with 9-km resolution and a 51-member ensemble with 18-km resolution induced an extensive study of the forecast skill of both raw and postprocessed dual-resolution predictions comprising ensemble members of different horizontal resolutions. We investigate the predictive performance of the censored shifted gamma (CSG) ensemble model output statistic (EMOS) approach for statistical postprocessing with the help of dual-resolution, 24-h, precipitation accumulation ensemble forecasts over Europe with various forecast horizons. We consider the operational 50-member ECMWF ensemble as of high resolution and extend it with a low-resolution (29-km grid), 200-member experimental forecast. The investigated dual-resolution combinations consist of subsets of these two forecast ensembles with equal computational cost, which is equivalent to the cost of the operational ensemble. Our case study verifies that, compared with the raw ensemble combinations, EMOS postprocessing results in a significant improvement in forecast skill and that skill is statistically indistinguishable between any of the analyzed mixtures of dual-resolution combinations. Furthermore, the semilocally trained CSG EMOS provides an efficient alternative to the state-of-the-art quantile mapping without requiring additional historical data.
A Comparison of Right-Moving Supercell and Quasi-Linear Convective System Tornadoes in the Contiguous United States 2003–21
Authors: Thompson Richard L. 
Published: May 2023

Abstract
Tornadoes produced by right-moving supercells (RMs) and quasi-linear convective systems (QLCSs) are compared across the contiguous United States for the period 2003–21, based on the maximum F/EF-scale rating per hour on a 40-km horizontal grid. The frequency of QLCS tornadoes has increased dramatically since 2003, while the frequency of RM tornadoes has decreased during that same period. The finding of prior work that the most common damage rating for QLCS tornadoes at night is EF1 persists in this larger, independent sample. A comparison of WSR-88D radar attributes between RM and QLCS tornadoes shows no appreciable differences between EF0 tornadoes produced by either convective mode. Differences become apparent for EF1–2 tornadoes, where rotational velocity is larger and velocity couplet diameter is smaller for RM tornadoes compared to QLCS tornadoes. The frequency of tornadic debris signatures (TDSs) in dual-polarization data is also larger for EF1–2 RM tornadoes when controlling for tornadoes sampled relatively close to the radar sites and in those occurring during daylight versus overnight. The weaker rotational velocities, broader velocity couplet diameters, and lower frequencies of TDSs both close to the radar and at night for QLCS EF1 tornadoes suggest that a combination of inadequate radar sampling and occasional misclassification of wind damage may be responsible for the irregularities in the historical record of QLCS tornado reports.

Significance Statement
A comparison of radar attributes between tornadoes with right-moving supercells and squall-line mesovortices suggests some irregularities in squall-line tornado records in the contiguous United States. The irregularities appear to be the result of both inadequate radar sampling for the relatively shallow squall-line tornadoes and occasional misclassification of wind damage with the lack of other corroborating evidence, especially overnight.
The role of specialised content knowledge in teaching basic life support
Authors: Madou Tom , Depaepe Fien , Ward Phillip , Iserbyt Peter 
Published: May 2023

Objective: To investigate the role of specialised content knowledge in instructor training on the teaching and learning of basic life support (BLS) in secondary schools. Design: Cluster randomised controlled trial. Setting: Data were collected in three Flemish secondary schools during physical education classes. Method: Three secondary schools were randomly assigned to a 60-minute BLS instructor training without (one school, three teachers) or with (two schools, five teachers) a focus on recognising and addressing common errors. Knowledge of common errors in the performance of BLS and how to correct these is referred to as specialised content knowledge. Following instructor training, all teachers taught BLS lessons to different students. Teachers’ use of time and interactions were assessed by means of systematic observation. BLS performance was assessed individually and unannounced to students ( n = 294) one week following their training using a validated protocol. Results: On average, specialised content knowledge teachers interacted more with their students compared to common content knowledge teachers (8 vs 3 teacher interactions per lesson to the class as a whole, 43 vs 31 teacher interactions per lesson to students individually). In addition, students taught by specialised content knowledge teachers achieved significantly higher BLS scores (66% vs 61%; p < .05). Overall, average BLS performance of students correlated positively with the amount of time reserved for hands-on practice, r(21) = .51; p < .05. Conclusion: Specialised content knowledge (i.e. recognising and addressing common errors) should be part of BLS instructor training courses.
Evaluation of psychometric properties of a leaflet developed for schizophrenia
Authors: Gopinath Deepak C , Joel Juno J , Bhat Shrinivasa U , Shetty Shraddha 
Published: May 2023

Background: Patients with severe mental illnesses like schizophrenia may benefit from a variety of patient education materials. Despite the availability of various resources, it is essential to assess the extent to which patients can comprehend the materials provided. Objective: This study aims to evaluate the reliability and readability of the patient information leaflet (PIL) for schizophrenia. Method: A quasi-experimental study was conducted for a period of 6 months in the departments of psychiatry. Patients with a diagnosis of schizophrenia were recruited for the study. A user-testing questionnaire was developed and validated with the help of an expert committee to assess reliability. Later, translated versions of the questionnaire were then administered to the patients based on their language preference and evaluated by test-retest analysis. The readability was assessed using pre-validated and translated versions of the PIL. Initially, baseline scores of patient knowledge were assessed using a reliable user-testing questionnaire. Later, their responses were reassessed again using the same questionnaire after reading the PIL. Results: A total of 45 patients participated in the study. From the total sample, 20 participants were randomly selected for reliability assessment. Intraclass-correlation coefficient (ICC), a statistical tool of reliability, give .6 for Kannada, .7 for Malayalam and 1 for the English version of the questionnaire. The overall patient’s knowledge was found to be improved from 50.4 to 76.4 after reading the PIL. Conclusion: Patients with schizophrenia were able to comprehend the information available on the PIL. Therefore, further research is needed to determine its efficacy in a larger population.
Taking sides: The role of universities in supporting community driven approaches to addressing poverty
Authors: Gratton Nicola 
Published: May 2023

Universities are often placed at the heart of their local communities and yet for some remain at arm’s length from the issues most affecting them. This viewpoint piece will use Staffordshire University as a case study to illustrate how universities can play a full and active role in addressing issues of hardship and the subtle ways in which their relative power can both help, or hinder, the process. It will argue that for universities to be able to make a difference to hardship they need to be aware of the underlying causes of hardship and challenge the power structures that create them, including their own. The viewpoint will use a number of university wide initiatives and projects to highlight what has worked and what hasn’t in Stoke-on-Trent. It will outline how storytelling and creative and digital engagement have been used to raise awareness of hardship, how the university have taken risks and embedded themselves in public and community spaces to reach people most affected by hardship and how strategic relationships have enabled the university to increase its impact. Crucially it will explore how working with communities to address issues of hardship is as much about how we do things as what we do.
Report of two sisters with Netherton syndrome successfully treated with dupilumab and review of the literature
Authors: Martin-García Cristina , Godoy Elena , Cabrera Adelaida , Cañueto Javier , Muñoz-Bellido Francisco J , Perez-Pazos Jacqueline , Dávila Ignacio 
Published: May 2023

Different monoclonal antibodies have been used for the treatment of Netherton’s syndrome (NS); secukinumab (anti-IL17A), infliximab (anti-TNF-α), ustekinumab (anti p40 subunit of IL-12 and IL-23), omalizumab (anti-IgE), and dupilumab (anti-IL4 and IL13). We report two sisters with severe NS who were treated with omalizumab in one and with secukinumab in the other. In view of the therapeutic failure, treatment with dupilumab was started in both sisters. The data were analyzed 16 weeks after starting treatment with dupilumab. Treatment response was assessed using the Severity Scoring Atopic Dermatitis (SCORAD); Eczema Area and Severity Index (EASI); Pruritus Numeric Rating Scale (NSR); Netherton Area Severity Assessment (NASA) and Dermatology Life Quality Index Ichthyosis. All scores were reduced after 16 weeks of treatment with dupilumab in both patients. She maintains improvement after 18 months and 12 months of treatment, respectively. No severe adverse events were reported. Treatment with dupilumab in two sisters with NS and atopic diseases produced a marked cutaneous improvement after a failed attempt with omalizumab and secukinumab. Further studies are needed to determine which biologic therapy is the most effective in NS.
Carotid Ultrasound Abnormalities of People Living With HIV in Kunming, China: Multiple Correspondence Analysis Approach to Identify Influencing Factors
Authors: Pan Shuishui , Fu Haiyan , Ai Zhiqiong , Li Chongxi , Bai Jinsong 
Published: May 2023

Background With the use of antiretroviral therapy (ART), the life expectancy of people living with HIV (PLWH) is gradually increasing, but subclinical atherosclerotic cardiovascular disease is becoming increasingly common in PLWH. Methods We obtained data from 326 PLWH. Based on the results of carotid ultrasonography, we divided patients into normal and abnormal carotid ultrasound groups and performed the χ2 test and multiple correspondence analysis (MCA) to determine the influencing factors of abnormal carotid ultrasound. Results Among the 326 PLWH, the overall abnormality rate of carotid ultrasound was 31.9% (104/326). MCA showed that carotid ultrasound abnormalities were markedly more common in patients with age (non-youth), BMI ≥24.0 kg/m2, hypertension, diabetes, hyperlipidemia, ART treatment ≥5 years, and CD4+T lymphocyte count <200/μL. Conclusion Carotid ultrasound is more likely to be abnormal when PLWH have higher age, BMI ≥24.0 kg/m2, hypertension, diabetes, hyperlipidemia, a longer course of ART, and a low CD4+ T lymphocyte count.
Essential Newborn Care Services in Nonpublic Health-Care Facilities in Southeast Nigeria
Authors: Iloh Ogochukwu N. , Iloh Kenechukwu K. , Osuorah Chidiebere D. I. , Onukwuli Vivian O. , Igbokwe Obianuju O. , Ezeudu Chijioke E. , Nwafia Ifeyinwa , Nwaneli Ezinne I. , Nwokeji-Onwe Linda 
Published: May 2023

Background The World Health Organization (WHO) has set some standards of essential newborn care (ENC) with some activities, the implementation of which minimizes the incidence of neonatal morbidity and mortality. This study attempted to assess the practice of ENC services among nonpublic health-care facilities and determinants of adequate ENC practice in southeast Nigeria. Methods This was a cross-sectional descriptive study carried out in 4 of the largest cities in southeast Nigeria. The studied facilities were selected by purposive and convenient sampling method. Scores were assigned to the practice of ENC and computed based on standard validated criteria. Data analysis was done using Epi Info version 7.2 and statistical significance was set at P < .05. Results A total of 77 health facilities in the study area were surveyed. The mean annual birth rate in the surveyed health facilities was approximately 342.2. Majority (64.9%) of the health facilities efficiently executed 3 of the 8 ENC practices while only 27 (35.1%) facilities had good essential newborn practices score. The city where the health-care facilities were located influenced the practice of adequate ENC. A greater proportion of health facilities located in Abakaliki and Awka practiced adequate ENC compared to facilities in Enugu and Nnewi ( P = .001). Conclusion ENC service is poor in nonpublic health-care facilities in southeast Nigeria. Training and retraining of health workers as well as provision of necessary incentives through government-private partnership may help ensure better implementation of ENC in order to reduce neonatal morbidity and mortality in southeast Nigeria.
Effect of Kangaroo Care Following Immersion Bath on Body Temperature in Preterm Neonates
Authors: Veeraiah Raju , Mangalgi Sharanabasavesh , Maralusiddappa Pradeep G. C. , Veerabhadraiah Krithika M. , Shenoy Sangeetha 
Published: May 2023

Objectives One of the aspects of routine care in stable preterm in the ward is bathing. However, during and after bath, drop in body temperature has been observed. Providing Kangaroo Mother Care (KMC) instead of routinely covering the baby with clothes following bath helps in better thermoregulation. The purpose of this study was to compare the effectiveness of standard care and KMC following immersion bathing in stable preterm neonates in postnatal ward. Patients and Methods Prospective nonrandomized interventional study done in the postnatal ward of a tertiary referral hospital. All consecutively born preterm neonates with corrected gestational age between 34 weeks and 37 weeks (mean 35 weeks +5) were enrolled in the study. Neonates received immersion bath in a tub using water temperature adjusted to 37 to 38℃. Neonates in this group were allocated to receive standard care and KMC immediately after bath on Day 1 and Day 2, respectively. Axillary temperature was recorded before bath (baseline), immediately after bath and subsequently at 15 min, 30 min, 45 min, and 60 min after bath. Data was analyzed to compare the effect of standard care and KMC immediately after bath. Results The pre-bath mean temperature between standard care and KMC were 36.27℃ and 36.47℃, respectively. In both standard care and KMC group immediately after bath there was no fall in temperature from baseline. Mean difference from baseline temperature between standard care and KMC group at 30 min, 45 min, and 60 min were 0.2℃, 0.25℃, and 0.18℃, respectively, all of which were statistically significant ( P < .05). Conclusions In this pilot study on immersion bathing followed by KMC, temperature regulation was better with KMC after bathing, with a mean temperature difference ranging between 0.18 ℃ and 0.25℃ (95% CI –0.103 to0.374) between 30 min and 60 min of bathing.
Persistent Buccopharyngeal Membrane – A Systematic Review of Case Reports and Case Series
Authors: Parekh Nishreen M. , Bansal Shivani P. , Mehta Vini , Shirsat Pankaj M. , Prasad Pooja , Desai Rajiv S. 
Published: May 2023

Objective Persistent buccopharyngeal membrane (PBM) is a rare anomaly associated with failure of ecto-endodermal resorption of the buccopharyngeal membrane on the 26th day of intrauterine life. The current literature has insufficient information about PBM. Design Systematic Review. Patients, Participants Online electronic databases such as PubMed-MEDLINE, Embase, and Scopus were searched using appropriate keywords from the earliest available data until 30th August 2022, with no language restriction. Additional sources such as Google Scholar, major journals, gray literature, conference proceedings, and cross-referencing were also explored. Main Outcome Measures The present systematic review evaluated and analysed the data available on PBM along with its treatment options and clinicopathological findings, prevalence, and prognosis of the patient. Results Thirty-four publications with 37 reported cases were included in this systematic review. The majority of patients had dyspnea (n = 18), followed by dysphagia (n = 10). Approximately 16 patients suffering from PBM reported orofacial abnormalities. Seventeen patients reported complete PBM, and 18 patients had partial PBM. The treatment modality followed by most patients (n = 15) was surgical excision of the membrane, along with stent placement in four patients. Oropharyngeal reconstruction was performed in four cases. The overall prognosis and survival rate of this rare condition is good. Conclusion This review suggests that PBM is poorly understood, and the diagnosis of partial PBM is confirmed only when the patient complains of difficulty in breathing or eating. In-depth analysis and follow-up of the reported cases should be performed to diagnose the disease early so that clinicians can provide adequate treatment to the patients.
Implementation of Non-pharmacological Interventions in Dementia Care: Family Caregiver Perspective
Authors: Ross Sabrina D. , Ziegert Nadja , Rodriguez Francisca S. 
Published: May 2023

Background: Non-pharmacological interventions show promising positive effects on dementia symptoms. Since the majority of dementia care activities are performed by family caregivers, it is important to know how they perceive and implement such approaches. We aimed to investigate the extent to which non-pharmacological interventions are considered by family caregivers in dementia care and the barriers they encounter in implementing them. Methods: A total of 30 family caregivers (mean age: 63.07 years, female: 70%) living inside (30%) and outside the homes (70%) of people with dementia participated. Descriptive data analysis was used to determine the frequency of non-pharmacological interventions implemented, perceived effects, lacking resources, and barriers, while inferential statistics were used to examine whether funding source varied between interventions with high versus low frequency. Results: The most frequently implemented non-pharmacological interventions were initiating/maintaining social contact, cognitively stimulating and rehabilitative activities, and time in nature. In general, enjoyment was the most commonly perceived effect of non-pharmacological interventions. Additional effects were reported with respect to well-being, cognitive decline, autobiographical memory, perception of competence, and other symptoms. Major barriers were organizational burden, accessibility, and a lack of funding. Further, lacking resources included a lack of services (e.g., therapies, transport, group activities) and information on possible interventions. Discussion: This study highlighted that family caregivers frequently implement non-pharmacological interventions in dementia care. Given the perceived positive effects on dementia symptoms, health care interventions are needed that address barriers and provide resources to foster the implementation of non-pharmacological interventions by family caregivers.
The Structure and Diagnostic Accuracy of the QbTest in Pediatric ADHD: A Retrospective Clinical Study
Authors: Stevanovic Dejan , Nasic Salmir , Doric Ana , Wentz Elisabet , Knez Rajna 
Published: May 2023

Objective: The QbTest that combines a continuous performance task (CPT) with a motion-tracking system may help identify attention deficit hyperactivity disorder (ADHD). This study examined the structure and diagnostic ability of the QbTest in children and adolescents. Method: Retrospective data from 1,274 children and adolescents were analyzed. The study assessed data on a principal component analysis (PCA), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: The QbActivity component included the variables micro-events, distance, area, and time active; the QbImpulsivity included normalized commissions and commissions (anticipatory errors were added in a version for 6–12-year-olds only); and the QbInattention included omissions, reaction time, and reaction time variation. Sensitivity ranged between 22% and 50%, specificity 79% and 96%, PPVs 40% and 95%, and NPVs 24% and 66%. Conclusion: The structure of the QbTest with three cardinal parameters and nine/ten CPT and motion analysis variables was supported. The diagnostic accuracy was found to be poor to moderate. Given that this is a retrospective study, the interpretation of diagnostic accuracy should be considered within this context.
Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis
Authors: Virupakshaiah Akash , Ladakis Dimitrios C , Nourbakhsh Bardia , Bhargava Pavan , Dilwali Sonam , Schoeps Vinicius , Borkowski Kamil , Newman John W , Waubant Emmanuelle 
Published: May 2023

Background: The circulating metabolome is altered in multiple sclerosis (MS), but its prognostic capabilities have not been extensively explored. Lipid metabolites might be of particular interest due to their multiple roles in the brain, as they can serve as structural components, energy sources, and bioactive molecules. Gaining a deeper understanding of the disease may be possible by examining the lipid metabolism in the periphery, which serves as the primary source of lipids for the brain. Objective: To determine if altered serum lipid metabolites are associated with the risk of relapse and disability in children with MS. Methods: We collected serum samples from 61 participants with pediatric-onset MS within 4 years of disease onset. Prospective longitudinal relapse data and cross-sectional disability measures (Expanded Disability Status Scale [EDSS]) were collected. Serum metabolomics was performed using untargeted liquid chromatography and mass spectrometry. Individual lipid metabolites were clustered into pre-defined pathways. The associations between clusters of metabolites and relapse rate and EDSS score were estimated utilizing negative binomial and linear regression models, respectively. Results: We found that serum acylcarnitines (relapse rate: normalized enrichment score [NES] = 2.1, q = 1.03E–04; EDSS: NES = 1.7, q = 0.02) and poly-unsaturated fatty acids (relapse rate: NES = 1.6, q = 0.047; EDSS: NES = 1.9, q = 0.005) were associated with higher relapse rates and EDSS, while serum phosphatidylethanolamines (relapse rate: NES = −2.3, q = 0.002; EDSS: NES = −2.1, q = 0.004), plasmalogens (relapse rate: NES = −2.5, q = 5.81E–04; EDSS: NES = −2.1, q = 0.004), and primary bile acid metabolites (relapse rate: NES = −2.0, q = 0.02; EDSS: NES = −1.9, q = 0.02) were associated with lower relapse rates and lower EDSS. Conclusion: This study supports the role of some lipid metabolites in pediatric MS relapses and disability.