bluuebunny/crossref_metadata_2025_split huggingface dataset:
MÍDIAS SOCIAIS COMO FERRAMENTAS PARA A EXTENSÃO REMOTA: UM RELATO DE EXPERIÊNCIA DE UMA LIGA ACADÊMICA DE ENFERMAGEM
Authors: Lopes Vivia Soares , Silva Maria do Livramento Lima da , Pereira Antônio Lucas de Brito , Cunha Luiz Guilherme de Sousa , Araújo Carlos Romualdo de Carvalho e 
Published: September 2023

Introdução: O Coronavírus da Síndrome Respiratória Aguda Grave 2 (SARS-CoV-2), causador da pandemia de COVID-19, tem causado problemas mundiais para além da doença, como na Educação, que, na impossibilidade da promoção de encontros presenciais, precisou encontrar formas de oportunizar a continuidade dos processos de ensino-aprendizagem. Desse modo, a Liga de Enfermagem em Saúde da Família, considerando o cenário pandêmico e a necessidade de seguir com as atividades, teve que se adequar ao formato remoto e usar da sua criatividade para transpor as barreiras físicas da sala de aula. Objetivo: Relatar as ações extensionistas desenvolvidas virtualmente pela Liga de Enfermagem em Saúde da Família, demonstrando sua importância para a formação acadêmica em Enfermagem. Metodologia: Trata-se de um estudo descritivo, do tipo relato de experiência, sobre atividades desenvolvidas por acadêmicos de Enfermagem na Liga de Enfermagem em Saúde da Família vinculada ao Curso de Enfermagem da Universidade Estadual Vale do Acaraú, Sobral, Ceará. Resultados: A extensão foi desempenhada de forma online por meio do Instagram e Youtube, com a criação de vídeos, imagens educativas e eventos com temas atuais e relevantes para a promoção da saúde, considerando a realidade sanitária, divididos em eixos: cooperação social, integração interprofissional, acadêmica e comunitária, politização acadêmica, datas comemorativas e vacinação. Conclusões: Esse relato reforça a interação universidade-sociedade frente a momentos de reestruturação, e a relevância das Ligas como estratégias extracurriculares de ensino, integrando-se à pesquisa e à extensão.
Palavras-Chave: Relações Comunidade-Instituição; Enfermagem; COVID-19; Redes Sociais Online; Promoção da Saúde.
O CONDICIONAMENTO DE TECIDO PERI-IMPLANTAR NA REABILITAÇÃO ESTÉTICA DE PRÓTESES UNITÁRIAS SOBRE IMPLANTES: RELATO DE CASO CLÍNICO
Authors: Costa Richelle Nunes , Marinho Liliane Cristina Nogueira , Pascoal Ana Luísa de Barros , Paiva Kêiverton Rones Gurgel , Dantas Wagner Ranier Maciel , Gurgel Bruno César de Vasconcelos , Calderon Patrícia dos Santos 
Published: September 2023

Introdução: A reabilitação protética implantosuportada de espaços edêntulos na região do sorriso é um desafio para o cirurgião-dentista. Para obtenção da estética em próteses unitárias sobre implante é necessário considerar aspectos como o correto posicionamento do implante e sua harmonia com os tecidos moles e duros. Objetivo: relatar o resultado estético e funcional de um tratamento com auxílio de coroa provisória associada ao condicionamento gengival na reabilitação final com coroa unitária implantossuportada. Relato de caso: Paciente MJFA, 36 anos, sexo feminino, compareceu à clínica de Prótese Dentária do Departamento de Odontologia/UFRN queixando-se de trauma dentário com perda do elemento dentário 15 e necessidade de “ficar com sorriso mais bonito”. Após instalação de implante com conexão cônica e período de osseointegração, foi realizada a confecção da coroa provisória sobre implante e iniciada sessões de condicionamento gengival por meio de acréscimos com resina acrílica, utilizando a técnica de pressão gradual sob a margem gengival. Observou-se uma melhora no tecido periimplantar e um perfil de emergência adequado. O caso possui proservação de 3 anos. Conclusão: a realização de condicionamento gengival previamente a prótese final é uma etapa importante para alcançar uma reabilitação com características estéticas e funcionais semelhantes à de dentes naturais.
RDR100: A Robust Computational Method for Identification of
Krüppel-like Factors
Authors: Malik Adeel , Kamli Majid Rasool , Sabir Jamal S.M. , Phan Le Thi , Kim Chang-Bae , Manavalan Balachandran 
Published: September 2023

Background:
Krüppel-like factors (KLFs) are a family of transcription factors containing zinc
fingers that regulate various cellular processes. KLF proteins are associated with human diseases, such as
cancer, cardiovascular diseases, and metabolic disorders. The KLF family consists of 18 members with
diverse expression profiles across numerous tissues. Accurate identification and annotation of KLF proteins
is crucial, given their involvement in important biological functions. Although experimental approaches
can identify KLF proteins precisely, large-scale identification is complicated, slow, and expensive.

Methods:
In this study, we developed RDR100, a novel random forest (RF)-based framework for predicting
KLF proteins based on their primary sequences. First, we identified the optimal encodings for ten
different features using a recursive feature elimination approach, and then trained their respective model
using five distinct machine learning (ML) classifiers.

Results:
The performance of all models was assessed using independent datasets, and RDR100 was selected
as the final model based on its consistent performance in cross-validation and independent evaluation.

Conclusion:
Our results demonstrate that RDR100 is a robust predictor of KLF proteins. RDR100 web
server is available at https://procarb.org/RDR100/.
Knockdown of PROM2 Enhances Paclitaxel Sensitivity in Endometrial Cancer Cells
by Regulating the AKT/FOXO1 Pathway
Authors: Jiang Jun , Zhang Chen , Wang Jianfen , Zhu Yingping , Wang Xinyan , Mao Peiyu 
Published: September 2023

Background:
Endometrial cancer is a very common and highly lethal reproductive malignant tumour in
women. Paclitaxel (PTX) is a usual drug utilized in chemotherapy for endometrial cancer. It has been uncovered that
PROM2 participates in the progression of various cancers through playing a promoter. However, the regulatory function
of PROM2 in PTX treatment for endometrial cancer remains unclear.

Methods:
The cell viability (IC50) was examined through CCK8 assay. The mRNA and protein expressions of genes
were measured through RT-qPCR and western blot. The proliferation was evaluated through colony formation and
EdU assays. The cell apoptosis was assessed through flow cytometry.

Results:
In this work, through bioinformatic analysis on online websites, it is found that the up-regulated expression of
PROM2 existed in endometrial cancer. In addition, the survival probability of UCEC patients with high PROM2 expression
was worse. This study adopted PTX treatment for obtaining the PTX-resistant cells (HEC-1A/PTX and
KLE/PTX). Furthermore, suppression of PROM2 enhanced PTX sensitivity through decreasing IC50 and proliferation
in endometrial cancer. Additionally, knockdown of PROM2 facilitated cell apoptosis in HEC-1A/PTX and KLE/PTX
cells. Next, we found that silencing of PROM2 retards the AKT/FOXO1 pathway. At last, rescue assays reversed the
strengthened PTX sensitivity mediated by PROM2 inhibition after SC79 treatment (AKT activator).

Conclusion:
Knockdown of PROM2 enhanced PTX sensitivity in endometrial cancer through modulating the
AKT/FOXO1 pathway. This study hinted that PROM2 may be a useful therapeutic target for PTX treatment in endometrial
cancer.
Antiarrhythmic Potential of Epicardial Botulinum Toxin Injection for
Suppression of Postoperative Atrial Fibrillation
Authors: Spartalis Michael , Spartalis Eleftherios , Iliopoulos Dimitrios , Siasos Gerasimos 
Published: September 2023

Abstract:
Following heart surgery, postoperative atrial fibrillation (AF) is the most prevalent kind of secondary AF and the most frequent adverse event.
Postoperative AF is related to a number of unfavorable cardiac outcomes, such as heart failure, stroke, and death. However, the pharmacological
treatment for postoperative AF is only relatively efficient and is frequently linked to detrimental complications, including symptomatic bradycardia
with atrioventricular block due to rate control drugs and elevated hemorrhage hazard attributable to the administration of anticoagulants. Ablation
procedures also result in the irreversible damage of cardiac anatomic structures, which may have long-term negative implications on heart
performance. As a result, there is an unmet demand for treatments that can minimize the incidence of postoperative AF in an effective and safe
manner. Botulinum toxin is an established neurotoxin that has progressively gained use in every medical science domain. It hinders the propagation
of impulses across nerve fibers without causing immediate damage to the cardiac tissue. The transient feature of botulinum toxin action and the
eventual restoration of the autonomic nervous system transmission are undeniably advantageous and may render botulinum toxin a potential and
feasible treatment approach for postoperative AF.
Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity
of Shikonin
Authors: Sun Chunguang , Liao Lin 
Published: September 2023

Abstract:
Thyroid cancer is one of the most common endocrine neoplasms. Treatment methods include surgical resection, radioactive iodine therapy, inhibition of thyroid-stimulating hormone, and inhibition of kinase-based target therapies. These treatments induced adverse effects. Lithospermum officinale possesses antioxidant, anticancer, burn-healing, and anti-inflammatory activities, and Shikonin is the main ingredient. Antithyroid cancer studies of Shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial–mesenchymal transition; induced cell cycle arrest; induced DNA damage and apoptosis by producing excessive reactive oxygen species; upregulated Bax; increased the stability of p53; decreased the expression of Mdm2; downregulated Slug and MMP-2, MMP-9, and MMP-14; repressed the phosphorylation of Erk and Akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of DNMT1; reduced the PTEN gene methylation; increased the expression of PTEN, leading to the inhibition of migration; increased LC3-II to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βII-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. In vivo studies showed that it is safe in Sprague–Dawley rats, Beagle dogs, and nude mice.
Measuring students' generic skills through national assessment
Authors: Makhshun Toha , A'la Bassam Abul , Kusaeri Kusaeri 
Published: September 2023

This study aims to measure the generic skills (GS) of Madrasah Aliyah (MA) students in Indonesia. Respondents who participated in this study were madrasah students scattered in East Java and Central Java as representatives of MAs in Indonesia. The method used in this research is a survey distributed via Google Form. Three dimensions are mentioned in the research instrument for measuring GS: religious moderation, critical and creative thinking skills, and interpersonal skills. Using SPPS version 16 software, a descriptive analysis was employed as the data analysis technique. The results of this study showed that the GS of students with religious moderation indicators obtained the highest average of 54.03% on the Likert scale 4. Critical and creative thinking skills indicators obtained the highest average results, 67.99%, on the Likert scale 4. The indicator of interpersonal skill obtained the highest average of 55.88% on the Likert 4 scale. Hence, it is expected of educational institutions to implement policies to enhance the GS of MA students, particularly in creating a more student-oriented learning model, also known as student-centered learning.
Effects of Web-Based and Mobile Self-Care Support in Addition to Standard Care in Patients After Radical Prostatectomy: Randomized Controlled Trial
Authors: Wennerberg Camilla , Hellström Amanda , Schildmeijer Kristina , Ekstedt Mirjam 
Published: September 2023

Background
Prostate cancer is a common form of cancer that is often treated with radical prostatectomy, which can leave patients with urinary incontinence and sexual dysfunction. Self-care (pelvic floor muscle exercises and physical activity) is recommended to reduce the side effects. As more and more men are living in the aftermath of treatment, effective rehabilitation support is warranted. Digital self-care support has the potential to improve patient outcomes, but it has rarely been evaluated longitudinally in randomized controlled trials. Therefore, we developed and evaluated the effects of digital self-care support (electronic Patient Activation in Treatment at Home [ePATH]) on prostate-specific symptoms.

Objective
This study aimed to investigate the effects of web-based and mobile self-care support on urinary continence, sexual function, and self-care, compared with standard care, at 1, 3, 6, and 12 months after radical prostatectomy.

Methods
A multicenter randomized controlled trial with 2 study arms was conducted, with the longitudinal effects of additional digital self-care support (ePATH) compared with those of standard care alone. ePATH was designed based on the self-determination theory to strengthen patients’ activation in self-care through nurse-assisted individualized modules. Men planned for radical prostatectomy at 3 county hospitals in southern Sweden were included offline and randomly assigned to the intervention or control group. The effects of ePATH were evaluated for 1 year after surgery using self-assessed questionnaires. Linear mixed models and ordinal regression analyses were performed.

Results
This study included 170 men (85 in each group) from January 2018 to December 2019. The participants in the intervention and control groups did not differ in their demographic characteristics. In the intervention group, 64% (53/83) of the participants used ePATH, but the use declined over time. The linear mixed model showed no substantial differences between the groups in urinary continence (β=−5.60; P=.09; 95% CI −12.15 to −0.96) or sexual function (β=−.12; P=.97; 95% CI −7.05 to −6.81). Participants in the intervention and control groups did not differ in physical activity (odds ratio 1.16, 95% CI 0.71-1.89; P=.57) or pelvic floor muscle exercises (odds ratio 1.51, 95% CI 0.86-2.66; P=.15).

Conclusions
ePATH did not affect postoperative side effects or self-care but reflected how this support may work in typical clinical conditions. To complement standard rehabilitation, digital self-care support must be adapted to the context and individual preferences for use and effect.

Trial Registration
ISRCTN Registry ISRCTN18055968; https://www.isrctn.com/ISRCTN18055968

International Registered Report Identifier (IRRID)
RR2-10.2196/11625
A Test of Positive Feedback Trading among Foreign Portfolio Investors in Nigeria
Authors: Abdulkadir Rihanat Idowu 
Published: September 2023

It has been established in the literature that the trading behavior of international investors may increase market vulnerability, especially for emerging markets. Consequently, this study examines whether positive feedback trading exists in the Nigerian stock market. Both descriptive and inferential analyses are carried out on monthly data covering the period 2013 to 2020. Specifically, the ARDL bounds testing approach is employed. Findings indicate that positive feedback trading exists in the market, as stock returns have positive and significant influence on foreign portfolio inflows. The results further show that this trading pattern becomes more prominent with rising economic growth. The findings again reveal that the exchange rate and the interest rate explain the foreign portfolio inflows in the Nigerian market. The study’s outcomes lend support for the pull theory in explaining the foreign portfolio inflow. However, no evidence is found in support of the push theory, as an explanation for the foreign portfolio inflow as the “OPEC basket crude oil price” is insignificant. It is thereby recommended that regulators should adopt measures that will help foreign investors to be better informed about the Nigerian market, in order to reduce their positive feedback trading behavior. Moreso, there is a need for the government to put in place policies targeted toward enhancing the growth of the stock market and the economy. In this way, the negative impact of such trading behavior will be minimal, as short-term trading by foreign investors will be reduced and the foreign portfolio inflows will be sustainable.
Identificación de riesgos en las cadenas de suministro de la industria automotriz: una revisión de literatura
Authors: Lopez Dominguez Sergio Ivan , Vázquez-Rueda Leonardo , Martínez Hernández Rosalba 
Published: September 2023

Objetivo: evidenciar la relevancia de la gestión de riesgos (GR) – particularmente en la fase de identificación de riesgos – en las organizaciones destacando la utilidad que tiene en el contexto de la cadena de suministro (CS) de la industria automotriz (IA).
Diseño metodológico: a través de una revisión de literatura de 44 artículos sobre GR en las CS de la IA, se seleccionaron 19 publicaciones de carácter empírico, publicadas entre los años 2018-2022, recuperados de las bases de datos: Google Scholar y Dimensions. Las publicaciones se encuentran en un contexto global y pertenecen a clasificaciones emitidas por Scimago Q1 a Q4.
Resultados: se detectaron 17 tipologías diferentes de riesgos, entre las que destacan los riesgos impulsados por la demanda y los riesgos de adquisición. Específicamente los tipos de riesgo que se identifican con mayor frecuencia son los relacionados a la baja calidad en piezas y comunicación deficiente con proveedores. La principal contribución de este trabajo es una tipología de riesgos.
Limitaciones de la investigación: la subjetividad que pudo existir al momento que los investigadores evaluaron los riesgos y el no contar con marcos de referencia formal de GR.
Hallazgos: los principales hallazgos indican que la GR es una herramienta de gestión que mejora el desempeño de la IA al ofrecer criterios para identificar los factores de riesgo en una economía mundial, considerándolos no solo como amenaza, incluso como oportunidad.
A machine learning parameterization of clouds in a coarse-resolution climate model for unbiased radiation
Authors: Henn Brian , Jauregui Yakelyn R. , Clark Spencer K. , Brenowitz Noah D. , McGibbon Jeremy , Watt-Meyer Oliver , Pauling Andrew G. , Bretherton Christopher S. 
Published: September 2023

Coarse-grid weather and climate models rely particularly on
parameterizations of cloud fields, and coarse-grained cloud fields from
a fine-grid reference model are a natural target for a machine-learned
parameterization. We machine-learn the coarsened-fine cloud properties
as a function of coarse-grid model state in each grid cell of NOAA’s
FV3GFS global atmosphere model with 200 km grid spacing, trained using a
3 km fine-grid reference simulation with a modified version of FV3GFS.
The ML outputs are coarsened fine fractional cloud cover and liquid and
ice cloud condensate mixing ratios, and the inputs are coarse model
temperature, pressure, relative humidity, and ice cloud condensate. The
predicted fields are skillful and unbiased, but somewhat
under-dispersed, resulting in too many partially-cloudy model columns.
When the predicted fields are applied diagnostically (offline) in
FV3GFS’s radiation scheme, they lead to small biases in global-mean
top-of-atmosphere (TOA) and surface radiative fluxes. An unbiased global
mean TOA net radiative flux is obtained by setting to zero any predicted
cloud with grid cell mean cloud fraction less than a threshold of 6.5%;
this does not significantly degrade the ML prediction of cloud
properties. The diagnostic, ML-derived radiative fluxes are far more
accurate than those obtained with the existing cloud parameterization in
the nudged coarse-grid model, as they leverage the accuracy of the
fine-grid reference simulation’s cloud properties.
East Central Europe and Communism: Politics, Culture and Society 1943–1991
Authors: Oldberg Ingmar 
Published: September 2023

Trots titeln East Central Europe and Communism: Politics, Culture and Society 1943–1991 täcker denna bok alla eight Östeuropas tidigare kommunistiska länder, inklusive »vildarna» Jugoslavien och Albanien som inte kontrollerades av Moskva. I varje land granskar Ramet kronologiskt kommunisternas politik och maktkamp, ekonomiska konsekvenser som industrialisering och jordbrukskollektivisering, men inte minst politikens effekter inom kultursfären, inklusive kyrkorna, samt kvinnornas ställning, vilka är viktiga men ofta försummade ämnen. Hon konkluderar med funktionalisten Robert Mertons terminologi att det kommunistiska systemet inte fungerade i något land med växande missnöje och opposition som icke avsedda eller insedda följder.
Despite its title, East Central Europe and Communism: Politics, Culture and Society 1943–1991, this book covers all eight ex-Communist states in Eastern Europe, including the mavericks Yugoslavia and Albania, which were not controlled by Moscow. Ramet chronologically analyses the communist policies and power struggles in each country, and consequences such as industrialization and collectivisation of agriculture. Not least, she looks at effects in the cultural sphere, including the churches, and the changing situation for women. Ramet concludes, using the sociologist Robert Merton's terminology, that the communist system did not work in any of these countries, and growing disaffection and opposition are among the unintended and actual results.
Is it Possible to Increase the Quality of Sexual Life After Spontaneous Birth?
Authors: Brezeanu Dragos , Brezeanu Ana-Maria , Tica Vlad-Iustin 
Published: September 2023

Abstract
The decrease in number of vaginal births may also be due to the discomfort caused by the episiotomy wounds.
Episiotomy wounds are characterized by discomfort, stinging, vulvodynia.
The decrease in immunity, the increase in vaginal pH during pregnancy and pregnancy, can cause the appearance of bacterial vulvovaginitis and can lead to poor healing of the episiotomy wound.
The patients will be initially evaluated by means of a questionnaire at 24 hours postpartum and then reevaluated at 7 days, when the suture material is removed, by completing the same questionnaire. Bacteriological vaginal secretion examination will also be collected both at 24 hours postpartum and at 40 days.
Visual scales will also be used (REEDA scale, VANCOUVER), at 7 days and at 40 days.
Thus, starting from the question, is postpartum sexual life influenced by episiotomy wounds, we will try to find an answer to this question by applying a questionnaire prepared by us.
Full Potential Linearized Augmented Plane Wave Calculations of Electron and Positron Energy Levels in TlBr and TlCl
Authors: Bousahla Mohammed Alaa , Bousahla Mohammed Nadir , Bousahla Zouaoui , Khachai Houari , Bendjilali Hadjer , Benkatlane Aissa 
Published: September 2023

Abstract
Theoretical research was conducted on the energy levels of electrons and positrons in zinc-blend TlBr and TlCl using the first-principle full potential linearized augmented plane wave method based on the gradient generalized approximation GGA. The study involved the calculation of electron and positron band structures which provided predictive data on several properties such as positron mobility, positron affinity, diffusion constants, effective masses, and positronium work function.