bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audit of antibiotics usage in an intensive care unit of a tertiary care hospital in South India
Authors: Rajendran R Judah , Seralathan Sujitha Elan 
Published: December 2022

Background:
Antibiotics are one of the major medications used in the intensive care unit (ICU). It is a matter of concern as inappropriate usage of antibiotics in the ICU has led to the development of many infections due to multidrug-resistant (MDR) organisms. The aim was to monitor and assess the empirical antibiotic treatment initiated and the changes made in antimicrobial therapy following the culture report.

Methodology:
The study was conducted from May 2018 to June 2018 after obtaining ethical clearance from the institute ethics committee which was a cross-sectional prospective type of study. One hundred patients who were on antibiotics were included in the study. A total of 249 culture samples were sent which included blood, urine, endotracheal aspirate, sputum, cerebrospinal fluid, wound swab, etc., The patients were started empirically with antibiotics ceftriaxone, imipenem, meropenem, amikacin, azithromycin, etc., The microorganisms grown in the culture were Escherichia coli, Acinetobacter species, Staphylococcus aureus, Pseudomonas aeruginosa, etc.

Results:
It was observed that for 54 patients, the empirical antibiotic treatment was continued, for 39 patients, there was a change in antibiotics following the culture report, and for Seven patients, the antibiotics were stopped. Among 39 patients, for 23 patients, there was an escalation, and for 16 patients, there was a de-escalation in the usage of antibiotics from the initial empirical treatment given.

Conclusion:
A proper prescription pattern and a standard antibiotic policy for prescribing antibiotics are needed to prevent the future development of MDR strains.
Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
Authors: Miftahussurur Muhammad , Waskito Langgeng Agung , Syam Ari Fahrial , Nusi Iswan Abbas , Wibawa I Dewa Nyoman , Rezkitha Yudith Annisa Ayu , Fauzia Kartika Afrida , Siregar Gontar Alamsyah , Akil Fardah , Waleleng Bradley Jimmy , Saudale Alexander Michael Joseph , Abubakar Azzaki , Maulahela Hasan , Richardo Marselino , Rahman Abdul , Namara Yoma Sari , Sudarmo Eko , Adi Pangestu , Maimunah Ummi , Setiawan Poernomo Boedi , Doohan Dalla , Uchida Tomohisa , Dewayani Astri , Rejeki Purwo Sri , Sugihartono Titong , Yamaoka Yoshio 
Published: December 2022

Background:
Chronic dyspepsia's symptoms are frequently seen in primary to tertiary healthcare in Indonesia. This study aimed to describe the potential usability of pepsinogen (PG) values in determining gastric mucosal conditions, including superficial gastritis and atrophic gastritis.

Materials and Methods:
We recruited 646 adult dyspeptic patients and then analyzed PG values (including PGI, PGII, and PGI/II ratio) with endoscopic findings, gastric mucosal damages, and Helicobacter pylori infection. The gastric mucosal damage and H. pylori infection were evaluated using histological examination based on the updated Sydney system.

Results:
Among 646 enrolled patients, 308 (47.2%), 212 (32.8%), 91 (14.1%), 34 (5.2%), and 1 (0.2%) patient were diagnosed with normal mucosa, gastritis, reflux esophagitis, peptic ulcer disease, and gastric cancer, respectively. Significant differences in PGI, PGII, and PGI/II ratio values were observed among ethnic groups (all P < 0.01). The PGI and PGII levels were significantly higher and PGI/II was significantly lower in H. pylori-infected patients than in uninfected ones (all P < 0.001). The optimal cutoff value for PGII and PGI/II was 12.45 ng/mL with an area under the curve (AUC) value of 0.755 (0.702–0.811), sensitivity 59.3%, and specificity 77.1%; and 4.75 with AUC value of 0.821 (0.763–0.855), sensitivity 81.5%, and specificity 78.7%, respectively, to determine moderate–severe atrophy.

Conclusion:
Serum PG levels, a useful biomarker, represent the endoscopic findings, especially for reflux esophagitis. In addition, the benefits of PG values detecting atrophic gastritis were limited to moderate–severe atrophic gastritis. This usefulness requires careful attention for several ethnic groups in Indonesia.
Death probability analysis in the old aged population and smokers in India owing to COVID-19
Authors: Jamdade Parikshit Gautam , Jamdade Shrinivas Gautamrao 
Published: December 2022

OBJECTIVE:
Research has shown that older people and smokers have a higher death probability from coronavirus disease 2019 (COVID-19). Thus, we investigated the effect of COVID-19 on death probability for individuals aged 65–70 years and smokers in India.

MATERIALS AND METHODS:
We did so using a differential learning (feed-backward) model. In the present study, we examined World Health Organization (WHO) declared COVID-19 data of India. We divided the patients into two groups accordingly: the population aged 65–70 years and female or male smokers.

RESULTS:
We observed that in the early stages of infection (up to 5 days), there was higher death probability in the older population; among smokers, it occurred in the middle period after infection (5–8 days). We estimated that the death probability among smokers was 1.905 times that of the older population.

CONCLUSION:
As Government of India, taking various initiatives to curb the spread of COVID-19, but these are not enough, so we suggest measures that should help to reduce COVID-19 infection in India.
Diagnostic performances of celiac disease serological tests among Saudi patients
Authors: Sghiri Rim , Hassine Hana Ben , Almogren Adel , Shakoor Zahid , Alswayyed Mohammed 
Published: December 2022

Background:
The prevalence of celiac disease (CD) is relatively high in Saudi Arabia, and little is known about the accuracy of serological markers in the local population. This study aimed to assess the diagnostic performance of various serological markers for detecting CD in Saudi children and adults.

Methods:
We conducted a retrospective study of 148 CD patients and 512 controls to assess the diagnostic performances of IgA anti-tissue transglutaminase antibodies (TTG), IgG anti-TTG, IgA anti-deamidated gliadin peptide antibodies (anti-DGP), IgG anti-DGP, and endomysium antibodies (EMA).

Results:
Immunoglobulin A (IgA) anti-TTG was the most sensitive test [98.9% (95% confidence interval (CI) 94.1–99.8%)], while EMA was the most specific [100%, 95%CI 98.6–100%]. By applying the criteria of IgA anti-TTG titers ≥10 × upper limit of normal (ULN) and positive EMA, 57.3% of patients could have avoided intestinal biopsy. IgG anti-DGP test had a sensitivity of 85.9% (95% CI = 77.3–91.5%) and a specificity of 93.5% (95% CI = (90.0–95.9%). Titers of IgA anti-TTG, IgA anti-DGP, and IgG anti-DGP were higher in CD patients with the Marsh 3c class than in those with the Marsh 3b and Marsh 3a classes. IgG anti-TTG and IgA anti-DGP had no additional diagnostic value.

Conclusions:
IgA anti-TTG and EMA are excellent CD markers in children and adults. The use of IgA anti-TTG titers ≥10 × ULN and positive EMA as criteria for CD diagnosis in children and adults might be a good alternative to intestinal biopsy.
In vitro and in vivo phototoxicity on gastric mucosa induced by methylene blue
Authors: Oh Hui Yeong , Choi Hyun Ho , Kim Eui Jin , Choi Ji Jin , Choi Sung Sook , Lee Hae Kyung , Kim Hyung-Keun , Kim Sang Woo , Park Won Sang H. , Chae Hiun Suk 
Published: December 2022

Background:
Methylene blue (MB) is used endoscopically to demarcate tumors and as a photosensitizer in photodynamic therapy (PDT). However, there are few in vivo studies about its toxicity in healthy stomach tissue. We performed sequential in vitro and in vivo analyses of MB-induced phototoxicity.

Methods:
We performed in vitro experiments using the AGS human gastric cancer cell line treated with light-emitting diode (LED) irradiation (3.6 J/cm2) and MB. Cytotoxicity was evaluated using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay. In vivo toxicity was evaluated in the stomach of beagles using the same dose of fiber-optic LED via gastroscopy, after spraying 0.1% and 0.5% MB solutions. Stomach tissue was also evaluated using the TUNEL assay.

Results:

In vitro, increased concentrations of MB led to higher TUNEL scores. However, cell viability was significantly lower after MB plus LED irradiation than after treatment with MB alone (P < 0.001). In vivo, the TUNEL score was highest immediately after treatment with 0.1% or 0.5% MB plus light irradiation, and the score was significantly higher in the LED illumination plus MB group than in the control group (P < 0.05). The elevated TUNEL score was maintained for 3 days in the MB plus light irradiation group but returned to normal levels on day 10.

Conclusions:
Endoscopic light application with MB 0.5% concentration to the stomach may be regarded as a safe procedure despite some DNA injuries in the early period.
GAME EDUKASI DIGITAL ULAR TANGGA BERMUATAN ETNOMATEMATIKA DI SEKOLAH DASAR
Authors: Suriyana Suriyana , Nizarrahmadi Nizarrahmadi 
Published: December 2022

Abstract: Research This research aims to create a digital educational game based on ethnomathematics in Snakes and Ladders game. This research was conducted at the 51 Sungai Raya State Elementary School, Kubu Raya Regency. The method that will be used in this research is the method of developing the development method is 4-D (Four D Model). Based on the results of the validity test conducted by 2 experts, it shows a valid level of validity with an average of 3.8 with details of material experts with a score of 3.9 while media experts score an average value of 3.7 with valid criteria. As for the effectiveness of the results of student responses, 3.52 states that students agree with learning mathematics, especially integer operations, while the evaluation of the results of the overall percentage of students who complete is 86% in elementary schools practical to use. Keywords: Snakes and Ladders Educational Game, Ethnomathematics. Abstrak: Penelitian Penelitian ini bertujuan untuk membuat game edukasi digital berbasis etnomatematika dalam permainan Ular Tangga. Penelitian ini dilaksanakan di Sekolah Dasar Negeri 51 Sungai Raya Kabupaten Kubu Raya. Metode yang akan digunakan dalam penelitian ini adalah metode pengembangan metode pengembangannya adalah 4- D (Four D Model). Berdasarkan hasil uji validitas yang dilakukan oleh 2 ahli, menunjukan tingkat kevalidan yang valid dengan rerata 3,8 dengan rincian ahli materi dengan skor nilai 3.9 sedangkan ahli media skor nilai rata rata 3.7 dengan kreteri valid. Sedangkan untuk ke efektivitas hasil dari repon siswa bahwa 3.52 denagn menyatkan bahwa siswa setuju dengan pembelajaran matematika khusunya operasi bilnagan bulat, sedangkan evaluasi hasil keseluruhan persentase siswa yang tuntas adalah 86% di Sekolah Dasar praktis untuk digunakan Kata Kunci: Game Edukasi Ular Tangga, Etnomatematika.
The Pengaruh Terapi Healing Garden Terhadap Tingkat Kecemasan Pasien Rawat Inap Di Rumah Sakit Panti Nugroho Pakem
Authors: Yuliati Agnes , Oktri Hastuti Agustina Sri , Rina Setyani Fransisca Anjar 
Published: December 2022

Latar belakang : Healing garden atau taman penyembuh merupakan sebuah sarana terapi alam bagi pasien dengan menghadirkan suasana alam sehingga pasien dapat berinteraksi dengan alam disekitarnya dengan tujuan membuat pasien merasa nyaman, relaks, optimis, dan bersemangat. Terapi healing adalah terapi rehabilitasi dan terapi secara fisik maupun nonfisik dengan cara mengajak pasien ke suatu taman yang berada di lingkungan RS untuk dilakukan entertain (media musik, menyanyi) dan edukasi yang bertujuan memberikan efek relaksasi kepada pasien Pasien yang dirawat dirumah sakit merupakan salah satu kelompok yang rawan mengalami kecemasan. Keberadaan taman di lingkungan rumah sakit diharapkan menjadi faktor penunjang dalam membantu proses penyembuhan pasien
Hubungan Antara Beban Kerja Dengan Kepatuhan Perawat Dalam Pendokumentasian Early Warning System (EWS) Di Ruang Rawat Inap Rumah Sakit Panti Rahayu Gunung Kidul
Authors: Widegdo Hernyu , Marti Eva , Ratnawati Emmelia 
Published: December 2022

ABSTRAK

Latar belakang: Beban kerja yang tinggi menyebabkan perawat menjadi tidak patuh melakukan dokumentasi, sehingga menyebabkan beberapa bagian kecil dokumentasi terlewat. Terutama pada malam hari dimana jumlah perawat pada malam sedikit sedangkan pasien yang dirawat banyak.
Tujuan: Penelitian ini mengetahui hubungan antara beban kerja perawat dengan kepatuhan pendokumentasian EWS di rawat inap Rumah Sakit Panti Rahayu.
Metode: Desain penelitian ini mengunakan kuantitatif dengan survey observasional analitik dengan pendekatan cross sectional. Populasi pada penelitian ini berjumlah 41 perawat. Dan diambil sample sejumlah 38 responden yang mengisi kuisioner, dengan teknik sampling berupa total sampling dengan teknik pengumpulan data dengan kuisioner google form.
Result: Dari hasil unvariat didapatkan responden yang bekerja di Rumah Sakit Panti Rahayu Hampir setengah berada dalam rentang umur, remaja akhir sebanyak 44,7%, Hampir seluruhnya berjenis kelamin perempuan sebanyak 84,2%, Hampir seluruhnya berlatar belakang pendidikan D3 Keperawatan sebanyak 86,8%, Hampir setengahnya perawat dengan jabatan fungsional PKWT sebanyak 55,3%. Dari hasil bivariate didapatkan hampir setengahnya perawat memiliki beban kerja yang sedang sebanyak 42,10% dan sebagian besar memiliki tingkat kepatuhan yang cukup sebanyak 65,8%, dengan menggunakan uji spearmant rank didapatkan hasil koefisien korelasi bernilai -510 dengan p-value 0,001 (< 0,05), yang berarti beban kerja semakin tinggi, maka kepatuhan semakin menurun.
Simpulan: Adanya hubungan antara variable beban kerja dengan kepatuhan dalam pendokumentasian EWS. Diharapkan bagi keperawatan hasil penelitian ini dapat mengurangi beban kerja yang dirasakan perawat dan dapat meningkatkan kepatuhan perawat dalam melakukan dokumentasi EWS di Rumah Sakit Panti Rahayu
Keyword : Beban Kerja, Kepatuhan, Pendokumentasian EWS.
PENYULUHAN PERILAKU HIDUP BERSIH DAN SEHAT PADA SISWA MTS DAN PESANTREN DI ERA NEW NORMAL
Authors: Yuliasari Alfiyana , Anantama Agam , Armila Armila , Achfandhy Mochammad Irfan 
Published: December 2022

Clean and healthy living behavior (PHBS) is an effort to spread experiences regarding healthy lifestyles through individuals, groups and the wider community with communication channels as a medium for sharing information. In the era of the new normal of the Covid-19 pandemic, clean and healthy living behaviors must continue to be applied to prevent the transmission of various diseases that cause illness and death. The main purpose of PHBS counseling is to create school communities who are health conscious and have the knowledge and awareness to live a life that maintains cleanliness and meets health standards. Counseling was carried out to 22 students of class VII MTs Riyadlatul Ulum who are also students of Islamic boarding schools. The counseling program started with an opening and remarks from representatives from the school, pre-test, counseling session, post-test, and the last closing and photo session. Overall, there is an increase of the average score from pre test and post test with the rise 0.14. Students are very enthusiastic about participating in outreach activities and it is hoped that there will be more health counseling held in their school so that students are more motivated to improve their health and the environment.
3º CONGRESSO INTERDISCIPLINAR DA ÁREA MÉDICA
Authors: Recima 21 Revista 
Published: December 2022

Com o apoio do Conselho Regional de Medicina de Minas Gerais, Sociedade Brasileira de Urologia e Sociedade Brasileira de Ortopedia e Traumatologia Regional Minas Gerais, o 3º Congresso Interdisciplinar da Área Médica, 3º CIAM, foi um evento 100% on-line, que ocorreu nos dias 23, 24 e 25 de setembro de 2022 contando com estudantes de todas as faculdades de medicina do Brasil. O evento contou com cerca de 72 palestrantes, que, com propriedade, ensinaram uma medicina baseada em evidência e que tem a humanização como sua defesa. O congresso foi realizado ao vivo e com até 3 palestras ocorrendo de maneira simultânea, dando assim a oportunidade de o inscrito optar por qual palestra de maior interesse gostaria de assistir. Mesmo a distância física, o 3º CIAM foi realizado ao vivo, e buscou maneiras para se manter próximo de seus congressistas, fornecendo em sua plataforma ferramentas de interação entre congressistas, mediadores e palestrantes através de chat de dúvidas e enquetes ao decorrer de toda transmissão do evento, mostrando ser possível se transformar a discussão em saúde através do ambiente virtual. Ademais, todas as palestras ficaram disponíveis na plataforma, posteriormente ao evento, por 60 dias, dando a oportunidade de o inscrito assistir todas as palestras novamente. O congresso abordou o tema “A medicina 4.0: Tecnologia, inovação no conhecimento e desenvolvimento de habilidades fora da curva”, com intuito de debater novas inovações tecnológicas no campo da medicina pós-pandemia e os seus benefícios para a sociedade.
A IMPORTÂNCIA DA ALTERAÇÃO DOS ÍNDICES DO TESTE DA CORRIDA DE 12 MINUTOS DA PORTARIA DO COMANDO-GERAL Nº 076-2016 - PMPR.
Authors: Camargo Felipe Furquim de , Lima Elizangela Cristina de 
Published: December 2022

O objetivo deste estudo foi demonstrar a importância da alteração dos índices do teste de corrida de 12 minutos estabelecidos pela Portaria do Comando-Geral nº 076/2016.Tratou-se de estudo de caráter descritivo, transversal, envolvendo pesquisas bibliográficas para desenvolvimento de revisão de literatura e pesquisa de campo para analisar os resultados de desempenho dos militares do estado do Paraná, considerados aptos nos Testes de Aptidão Física, mais especificamente o teste de corrida de 12 minutos realizados entre o período compreendido de agosto de 2019 a agosto de 2022. Os resultados da pesquisa realizada neste estudo apontaram que, apesar de 100% dos militares analisados terem sido aptos no teste de aptidão física aplicado pela Comissão de Inspeção de Promoção de praças e oficiais, 49,23% apresentaram índices insatisfatórios na corrida de 12 minutos, de acordo com os parâmetros estabelecidos pelo Colégio Americano de Medicina Esportiva (ACSM). Cabe salientar que, conforme estabelecido pela ACSM, 25,04% dos policiais militares apresentaram resultados definidos como “muito precários” e 24,18% como “precários”. Dessa forma, constata-se que os índices estabelecidos na corrida de 12 min. pela Portaria nº 076/2016 CG/PMPR, anteriormente à mudança instituída pela Portaria do Comando-Geral nº 384, de 03 de maio de 2022, para homens e mulheres, estavam abaixo do mínimo estabelecido internacionalmente. Concluiu-se que a alteração na Portaria do Comando-Geral nº 076/2016, aumentando a exigência nos índices da corrida de 12 minutos, mostra-se acertada e adequada para análise da condição de saúde e aptidão física do efetivo da Corporação.
Covid-19 ile Hemşirelik Eğitiminde Yeni Bir Yaklaşım: Harmanlanmış Öğrenme
Authors: KOCAAĞALAR AKİNCE Elif , GÜNGÖR Duygu Ceren , ÖZKÜTÜK Nilay , ORGUN Fatma 
Published: December 2022

21. yüzyılda bilgi ve iletişim teknolojilerindeki hızlı gelişmeler ve değişimler insan yaşamının her alanını etkilediği gibi, hemşirelik eğitim sistemini de etkilemekte olup, öğrenme-öğretme süreçlerinin değişime uğramasını ve yeni gelişmelere ayak uydurmasını zorunlu hale getirmektedir. Bu değişim ve gelişmelerin entegrasyonu, özellikle COVID-19 pandemisi ile mevcut eğitim sisteminin aniden çökmesine ve durmasına sebep olmasıyla daha çok önem kazanmıştır. Hemşirelik eğitimi teorik ve uygulamalı derslerden oluşması nedeniyle uzaktan eğitim yetersiz kalmış, uzaktan ve geleneksel eğitimin birleşimi olan harmanlanmış öğrenme önem kazanmıştır. Bu bağlamda hem ulusal hem de uluslararası hemşirelik eğitim kurumları harmanlanmış öğrenmeye COVID-19 pandemisi ile geçiş yapmak zorunda kalmışlardır. Harmanlanmış öğrenme ile hemşirelik öğrencileri 21. yy becerilerinden problem çözme, eleştirel düşünme, akıl yürütme, analitik düşünme becerilerini geliştirmekte, aynı zamanda hemşirelik öğrencilerinin akademik başarılarını, öğrenen motivasyonunu, eğitimin etkililiğini, aktif katılımı olumlu yönde etkilenmektedir. Bu derleme ile harmanlanmış öğrenme tanımları, kuramsal ve tarihsel gelişimi, modelleri, bileşenleri, avantajları ve dezavantajları sunularak, hemşirelik eğitim programına entegrasyon sürecinde harmanlanmış öğrenmenin desteklenmesi amaçlanmıştır.
Determination of Intermolecular Interactions of Nicotinamide Liganded Complexes of Co(II), Cu(II), Ni(II) and Zn(II) 4-Formilbenzoates by Hirshfeld Surface Analysis and Investigation of Interaction Energies.
Authors: SERTÇELİK Mustafa 
Published: December 2022

CrystalExplorer program is a program that has been used frequently in the field of theoretical chemistry in recent years and its popularity has increased. First of all, Hirshfeld surface analysis of molecules can be done in this program. Thanks to Hirshfeld surface analysis, intermolecular interactions and their contributions to the crystal surface can be determined. In this study, Hirshfeld surface analyzes and energy frameworks of nicotinamide complexes of Co(II), Cu(II), Ni(II) and Zn(II) 4-formylbenzoate were investigated. Dnorm index, shape index, curvature index and 2D fingerprint graphs were examined for all complexes. In addition, the intermolecular interaction energies of the complexes were calculated using the CE-B3LYP/6-31G (d,p) and CEHF/3-21G energy models. As a result of all these, it was seen that the most important interaction in the four isostructured complexes was H...H interactions.
According to Hirshfeld surface analysis and energy frameworks, O-H...O and N-H...O hydrogen bonds and π•••π stacking and C−H••π interaction energies are seen as the most important interaction types in the crystal structure.
South African urban youth responses to living in a world with COVID: Lessons from #Slam4urLife
Authors: Mazetti Cara , Schmidt Sophie , Hardie Mignon , Boulle Jacqueline , Parnell Susan 
Published: December 2022

Using poetry, visual art, songs, raps and sketches submitted to #Slam4urLife, a social media competition encouraging young people in South Africa to respond creatively to the COVID-19 pandemic, this article outlines young urban people’s responses to the COVID-19 pandemic in South Africa through four narratives: shock, loss, survival and activism. Resting on practices of engaged scholarship, it draws on knowledge bases and collaborations in and beyond the academy to contribute grounded research on arts-based social media competitions as an effective method for encouraging and amplifying the youth voice. It does this by creating digital public spaces in which young people can practise civic engagement in contexts where this cannot be done in physical public spaces. In doing so, the article contributes to the literature on community-based research and youth in African cities from the perspective of South Africa. It also argues the importance of art-based social media competitions in creating digital public spaces in which the youth voice can be encouraged, legitimised and amplified in so far as these kinds of digital spaces allow for a kind of civic engagement not always seen by young people in the physical public spaces of African cities.