bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in Numerical Weather Prediction of the 10 August 2020 Midwestern Derecho: Examples from the FV3-LAM
Authors: Gallus William A. , Harrold Michelle A. 
Published: June 2023

Abstract
A severe derecho impacted the Midwestern United States on 10 August 2020, causing over $12 billion (U.S. dollars) in damage, and producing peak winds estimated at 63 m s−1, with the worst impacts in Iowa. The event was not forecast well by operational forecasters, nor even by operational and quasi-operational convection-allowing models. In the present study, nine simulations are performed using the Limited Area Model version of the Finite-Volume-Cubed-Sphere model (FV3-LAM) with three horizontal grid spacings and two physics suites. In addition, when a prototype of the Rapid Refresh Forecast System (RRFS) physics is used, sensitivity tests are performed to examine the impact of using the Grell–Freitas (GF) convective scheme. Several unusual results are obtained. With both the RRFS (not using GF) and Global Forecast System (GFS) physics suites, simulations using relatively coarse 13- and 25-km horizontal grid spacing do a much better job of showing an organized convective system in Iowa during the daylight hours of 10 August than the 3-km grid spacing runs. In addition, the RRFS run with 25-km grid spacing becomes much worse when the GF convective scheme is used. The 3-km RRFS run that does not use the GF scheme develops spurious nocturnal convection the night before the derecho, removing instability and preventing the derecho from being simulated at all. When GF is used, the spurious storms are removed and an excellent forecast is obtained with an intense bowing echo, exceptionally strong cold pool, and roughly 50 m s−1 surface wind gusts.
The Political Effects of Witnessing State Atrocities: Evidence from the Nazi Death Marches
Authors: De Juan Alexander , Gläßel Christian , Haass Felix , Scharpf Adam 
Published: June 2023

How does witnessing regime atrocities influence the political attitudes of bystanders? We argue that observing regime violence against innocent civilians triggers psychological dissonance between beliefs about the regime and the witnessed moral transgression. As a result, regime support should decrease among bystanders of state atrocities. We analyze original, highly disaggregated archival data from the Nazi death marches at the end of World War II, which confronted ordinary German citizens with the regime’s crimes. We find that locations with higher victim numbers had lower vote shares for right-wing nationalist parties after the war. Supporting our proposed mechanism, we show that (1) this effect was strongest when Nazi crimes were at the center of public discourse and (2) that witnessing Nazi atrocities was associated with individuals’ rejection of Hitler 20 years later. The findings have implications for understanding democratization prospects and people’s nostalgia for fallen autocrats.
Cardiovascular surgical experiences of IVC tumor and thrombus: Operative strategies Based on 51 consecutive patients
Authors: Rahmanian Mehrzad , Badkoubeh Roya Sattarzadeh , Rasouli Seyed Jaber , Nowroozi Mohammad Reza , Saberi Kianoush , Salehi Mehrdad , Larti Farnoosh , Tajaddini Ali , Fatemian Hossein , Rad Mehrdad Rabiee , Dabaghi Ghazal Ghasempour , Malekhosseini Hamidreza 
Published: June 2023

Background The only beneficial treatment option for the management of inferior vena cava (IVC) tumor thrombus is complete tumor removal. The aim of this study was to report our experience in surgical and clinical outcomes in patients with tumor thrombosis in IVC. Methods A retrospective chart review of patients who underwent surgical resection of IVC tumor at our institution over the past 10 years was performed. The patients were identified using a prospectively maintained database. Results We identified 51 patients, the mean age was 53.4 ± 16.8 years, and 25.4% were female. They were divided into three groups based on tumor thrombosis level. Twenty patients (39.2%) required sternotomy, and cardiopulmonary bypass (CPB) was used in 19 (37.2%) patients, and 2 (3.9%) cases underwent coronary artery bypass graft. The perioperative complications were severe bleeding (3 patients), pulmonary embolism (2 patients), and duodenal perforation (1 patient). Three (5.8%) in-hospital deaths occurred, and all were due to severe abdominal bleeding. After a mean follow-up time of 46.5 ± 42.0 months, 29 (56.9%) patients were alive. The mean survival time was 75.2 ± 8.4 months. In multivariate analysis, higher age ( p = 0.033) and male gender ( p = 0.033) proved to be independent prognostic factors. Conclusions Tumor thrombus extending to the IVC is a rare and challenging event. Although using CPB may be safe and result in long-term survival with acceptable function, excessive bleeding during surgery may limit the use of this method.
Minimum 5-Year Clinical Outcomes of Arthroscopically Repaired Massive Rotator Cuff Tears: Effect of Age on Clinical Outcomes
Authors: Dey Hazra Rony-Orijit , Dey Hazra Maria E. , Hanson Jared A. , Rutledge Joan C. , Doan Kent C. , Ganokroj Phob , Horan Marilee P. , Dornan Grant J. , Millett Peter J. 
Published: June 2023

Background: Massive rotator cuff tears (MRCTs) can be challenging to treat, and the efficacy of repair of MRCTs in older patients has been debated. Purpose: To report minimum 5-year outcomes after primary arthroscopic rotator cuff repair of MRCT and determine whether age affects outcomes. Study Design: Case series; Level of evidence 4. Methods: The study included consecutive patients with MRCTs who were treated with arthroscopic rotator cuff repair by a single surgeon between February 2006 and October 2016. MRCTs were defined as ≥2 affected tendons with tendon retraction to the glenoid rim and/or a minimum exposed greater tuberosity of ≥67. Patient-reported outcome (PRO) data collected preoperatively and at a minimum of 5 years included the American Shoulder and Elbow Surgeons (ASES) score; Single Assessment Numeric Evaluation (SANE) score; the shortened version of the Disabilities of the Arm, Shoulder and Hand score (QuickDASH); the 12-Item Short Form Health Survey (SF-12) Physical Component Summary (PCS); and patient satisfaction. Surgical failure was defined as subsequent revision rotator cuff surgery or conversion to reverse total shoulder arthroplasty. Regression analysis was performed to determine whether age had an effect on clinical outcomes. Results: A total of 53 shoulders in 51 patients (mean age, 59.7 years; range, 39.6-73.8 years; 34 male, 19 female) met inclusion criteria with a mean follow-up of 8.1 years (range, 5.0-12.1 years). Three shoulders (5.7%) failed at 2.4, 6.0, and 7.1 years. Minimum 5-year follow-up was obtained in 45 of the remaining 50 shoulders (90%). Mean PROs improved as follows: ASES from 58.8 to 96.9 ( P < .001), SANE from 60.5 to 88.5 ( P < .001), QuickDASH from 34.2 to 6.8 ( P < .001), and SF-12 PCS from 41.1 to 52.2 ( P < .001). Patient satisfaction was a median of 10 (on a scale of 1-10). Age was not associated with any PRO measures postoperatively ( P > .05). Conclusion: This study demonstrated significantly improved clinical scores, decreased pain, and increased return to activity for patients with MRCT at midterm follow-up (mean, 8.1 years; range, 5.0-12.1 years). In this patient cohort, no association was found between age and clinical outcomes.
Effect of Whole Body Parameters on Knee Joint Biomechanics: Implications for ACL Injury Prevention During Single-Leg Landings
Authors: Sadeqi Sara , Norte Grant E. , Murray Amanda , Erbulut Deniz U. , Goel Vijay K. 
Published: June 2023

Background: Previous studies have examined the effect of whole body (WB) parameters on anterior cruciate ligament (ACL) strain and loads, as well as knee joint kinetics and kinematics. However, articular cartilage damage occurs in relation to ACL failure, and the effect of WB parameters on ACL strain and articular cartilage biomechanics during dynamic tasks is unclear. Purposes: (1) To investigate the effect of WB parameters on ACL strain, as well as articular cartilage stress and contact force, during a single-leg cross drop (SLCD) and single-leg drop (SLD). (2) To identify WB parameters predictive of high ACL strain during these tasks. Study Design: Descriptive laboratory study. Methods: Three-dimensional motion analysis data from 14 physically active men and women were recorded during an SLCD and SLD. OpenSim was used to obtain their kinematics, kinetics, and muscle forces for the WB model. Using these data in kinetically driven finite element simulations of the knee joint produced outputs of ACL strains and articular cartilage stresses and contact forces. Spearman correlation coefficients were used to assess relationships between WB parameters and ACL strain and cartilage biomechanics. Moreover, receiver operating characteristic curve analyses and multivariate binary logistic regressions were used to find the WB parameters that could discriminate high from low ACL strain trials. Results: Correlations showed that more lumbar rotation away from the stance limb at peak ACL strain had the strongest overall association (ρ = 0.877) with peak ACL strain. Higher knee anterior shear force (ρ = 0.895) and lower gluteus maximus muscle force (ρ = 0.89) at peak ACL strain demonstrated the strongest associations with peak articular cartilage stress or contact force in ≥1 of the analyzed tasks. The regression model that used muscle forces to predict high ACL strain trials during the dominant limb SLD yielded the highest accuracy (93.5%), sensitivity (0.881), and specificity (0.952) among all regression models. Conclusion: WB parameters that were most consistently associated with and predictive of high ACL strain and poor articular cartilage biomechanics during the SLCD and SLD tasks included greater knee abduction angle at initial contact and higher anterior shear force at peak ACL strain, as well as lower gracilis, gluteus maximus, and medial gastrocnemius muscle forces. Clinical relevance: Knowledge of which landing postures create a high risk for ACL or cartilage injury may help reduce injuries in athletes by avoiding those postures and practicing the tasks with reduced high-risk motions, as well as by strengthening the muscles that protect the knee during single-leg landings.
Lower Extremity Strains in the US National Football League, 2015-2019
Authors: Herzog Mackenzie M. , Weiss Leigh , Lee Rebecca Y. , Williams Tyler , Ramsden Sam , Sills Allen K. , Mack Christina D. 
Published: June 2023

Background: Lower extremity (LEX) strains, including hamstring, quadriceps, adductor, and calf strains, are among the most common injuries in sports. These injuries lead to high burden, resulting in significant missed participation time. Purpose: To describe the incidence of LEX strains in professional American football. Study Design: Descriptive epidemiology study. Methods: This study included all players who played in ≥1 National Football League (NFL) game or sustained a LEX strain during participation in the 2015-2019 seasons. LEX strain frequency was calculated by setting (game, practice, conditioning), timing in season (offseason, preseason, regular season, postseason), and roster position. Game incidence rates were calculated for season, roster position, and play type. LEX strains were identified in the standardized leaguewide electronic health record (n = 32 teams). Results: Across 5 years, 5780 LEX strains were reported among 2769 players (1-year risk, 26.7%; 95% CI, 26.0%-27.3%); 69% (n = 4015) resulted in time loss. Among all LEX strains, 54.7% were hamstring (n = 3163), 24.1% adductor (n = 1393), 12.6% calf (n = 728), 8.3% quadriceps (n = 477), and 0.3% multiple muscle groups (n = 19). Most were reported during preseason practices (n = 1076; 27%) and regular season games (n = 1060; 26%). The 2-week period of training camp practices comprised 19% of all time-loss strains. Among game injuries, preseason games had the highest rate of LEX strain (2.9/10,000 player-plays; 95% CI, 2.6-3.2). Defensive secondary players accounted for the highest proportion of time-loss LEX strains (27%; n = 1082). In games, punt plays had nearly twice the injury rate of kickoff plays (14.9/1000 plays [95% CI, 13.1-17.0] vs 7.5/1000 plays [95% CI, 6.2-8.9], respectively) and >3 times the rate of pass plays (4.3/1000 plays; 95% CI, 4.0-4.7) and run plays (2.6/1000 plays; 95% CI, 2.3-2.9). In aggregate, LEX strains led to an estimated 16,748 participation days missed each year and a median 12 days missed per injury. Conclusion: LEX strains affected 1 in 4 NFL players each year, resulting in a high burden of injury in terms of time lost from practice and competition. Safe return to the NFL season during training camp and reduction of injuries during regular season games are key focuses for future injury reduction.
Evaluation of workplace exposure to respirable crystalline silica in road construction industries in Alberta
Authors: Couture Ariel , Charuvil Elizabeth Rose Marie , Lefsrud Lianne , Sattari Fereshteh 
Published: June 2023

Occupational exposure to respirable crystalline silica (RCS) is common for several occupations in construction, not only because of its presence in many handling materials but also in processes such as grinding and sawing. This study investigated workplace exposure to RCS as quartz in industries and occupations within road construction in Alberta through the RCS monitoring database provided by the Alberta Roadbuilders and Heavy Construction Association (ARHCA) between 2007 and 2016. Descriptive statistics were calculated for exposure-related variables, and mixed model analysis was performed to determine factors affecting the exposure levels. Results showed that the highest exposed workers were in the sand and gravel industry (GM = 45 μg/m3). For worker occupations, geometric means ranged from 78 μg/m3 for crusher operators to 10 μg/m3 for concrete truck operators. The maximum exposure severity was 33.3 times the occupational exposure limit (OEL) for the sand and gravel and 31 times the OEL for tower operators. The results also showed the effect of seasonal variability on RCS exposure levels. The heterogeneous exposure results indicated significant room for improvement and that controls should focus more on the activity performed than the occupation to lower exposure to RCS levels in industries.
Association of Incremental peritoneal dialysis with residual kidney function decline in patients on peritoneal dialysis: The balANZ trial
Authors: Hayat Ashik , Cho Yeoungjee , Hawley Carmel M , Htay Htay , Krishnasamy Rathika , Pascoe Elaine , Teitelbaum Isaac , Varnfield Marliene , Johnson David W 
Published: June 2023

Background: Incremental peritoneal dialysis (PD), defined as less than Full-dose PD prescription, has several possible merits, including better preservation of residual kidney function (RKF), lower peritoneal glucose exposure and reduced risk of peritonitis. The aims of this study were to analyse the association of Incremental and Full-dose PD strategy with RKF and urine volume (UV) decline in patients commencing PD. Methods: Incident PD patients who participated in the balANZ randomised controlled trial (RCT) (2004–2010) and had at least one post-baseline RKF and UV measurement was included in this study. Patients receiving <56 L/week and ≥56 L/week of PD fluid at PD commencement were classified as Incremental and Full-dose PD, respectively. An alternative cut-point of 42 L/week was used in a sensitivity analysis. The primary and secondary outcomes were changes in measured RKF and daily UV, respectively. Results: The study included 154 patients (mean age 57.9 ± 14.1 years, 44% female, 34% diabetic, mean follow-up 19.5 ± 6.6 months). Incremental and Full-dose PD was commenced by 45 (29.2%) and 109 (70.8%) participants, respectively. RKF declined in the Incremental group from 7.9 ± 3.2 mL/min/1.73 m2 at baseline to 3.2 ± 2.9 mL/min/1.73 m2 at 24 months ( p < 0.001), and in the Full-dose PD group from 7.3 ± 2.7 mL/min/1.73 m2 at baseline to 3.4 ± 2.8 mL/min/1.73 m2 at 24 months ( p < 0.001). There was no difference in the slope of RKF decline between Incremental and Full-dose PD ( p = 0.78). UV declined from 1.81 ± 0.73 L/day at baseline to 0.64 ± 0.63 L/day at 24 months in the Incremental PD group ( p < 0.001) and from 1.38 ± 0.61 L/day to 0.71 ± 0.46 L/day in the Full-dose PD group ( p < 0.001). There was no difference in the slope of UV decline between Incremental and Full-dose PD ( p = 0.18). Conclusions: Compared with Full-dose PD start, Incremental PD start is associated with similar declines in RKF and UV.
Implementation and evaluation of a shared care model between oncologists and pharmacists for breast cancer patients at a Canadian regional ambulatory cancer centre
Authors: Goh Elaine , Labelle Sylvie , Chan Angela 
Published: June 2023

Background The introduction of CDK 4/6 inhibitors for breast cancer patients has contributed to increased ambulatory patient visits for oncologists. The Medication Assessment by Pharmacist program aims to evaluate the impact of oncology pharmacists performing medication assessment follow-up visits. Methods Breast cancer patients on a CDK 4/6 inhibitor deemed suitable by their oncologist for pharmacist assessment could be booked for a pharmacist medication assessment appointment at alternate treatment cycles. Results Between February 2019 to November 2021, 29 of 128 patients (22.7%) were selected for 46 total Medication Assessment by Pharmacist visits resulting in 920 min of clinic time savings for physicians. There were similar rates of adhering to provincial protocols for scheduling visits (99% vs. 96%, p  =  0.12) and monitoring investigations (98% vs. 98%, p  =  0.96) between those enrolled in Medication Assessment by Pharmacist or not. Surveys completed by medical oncologists and pharmacists demonstrated that nine of nine oncologists felt Medication Assessment by Pharmacist reduced workload and wanted Medication Assessment by Pharmacist expanded to additional oncology drugs. Pharmacist-completed surveys revealed that nine of nine pharmacists felt Medication Assessment by Pharmacist increased job satisfaction, and allowed further application of clinical skills. All agreed that patients were receptive to meeting with pharmacists. According to survey results, 33% of oncologists versus 100% of pharmacists routinely asked about medication adherence, new medications or supplements. Conclusion Integrating pharmacists into a shared care model reduces ambulatory patient visits for oncologists without deviating from provincial protocol guidelines for monitoring and visits for patients on CDK 4/6 inhibitors. Leveraging the medication expertise of pharmacists also increases the frequency of addressing medication adherence and concurrent therapies. Medication Assessment by Pharmacist may be an effective strategy in alleviating projected shortages of oncology providers.
Out-of-plane crashworthiness of hierarchical cellular topology with different wall thicknesses in hierarchies
Authors: Zhang Yuwu , Liu Guoliang , Liu Shu , Li Yugang 
Published: June 2023

Hierarchical honeycomb is a topology presenting better weight-efficiency than the conventional honeycomb. However, the existing research are mainly conducted based on an assumption of uniform in-plane wall thickness. Rare studies consider the effect of different wall thicknesses in hierarchies. This paper investigates the out-of-plane crashworthiness of vertex hexagonal-based hierarchical honeycombs with non-uniform wall thickness in distinct hierarchies experimentally and theoretically. The coupons with parent material of 316L steel are obtained using Selective Laser Melting fabricating technique. The experimental results indicate that the first order honeycombs with uniform wall thickness experience a failure mechanism transition from local elastic buckling to local plastic buckling of cell walls at the critical density of 0.0772. A progressive folding wave can be identified when relative density is lower than 0.0386. At any edge length ratio, the plateau crushing stress increases monotonously as the increase of the wall thickness ratio, but not for the half wavelength. Both the half wavelength and maximum plateau crushing stresses are linearly related to relative density. For the first order honeycombs, the effect of edge length ratio is more considerable on the plateau crushing stress than the wall thickness ratio. The second order honeycombs exhibit higher half wavelengths and maximum plateau crushing stresses than the first order honeycombs owing to the more considerable cell wall constraint among the hierarchies. Compared to the hierarchical honeycombs with uniform wall thicknesses at relative densities of 0.005∼0.0386, the non-uniform wall thickness enhances the maximum plateau crushing stress significantly, especially at a low relative density, and the maximum improvements for first order and second order honeycombs are 71.5 and 48.6%, respectively. However, the absolute improvements are similar, averaging approximately 1.18 MPa. This work provides a foundation for developing ultralight hierarchical material candidates applied in passive protection equipment, such as aircrafts and vehicles.
Outcomes of mechanical thrombectomy at a single-centre tertiary level public healthcare hospital in South Africa
Authors: Kiriinya Martin Muthinja , Bateman Kathleen , Qureshi Aamir , Feuvre David Le , Taylor Allan 
Published: June 2023

Introduction Mechanical thrombectomy (MT) is standard of care for acute ischaemic stroke from large vessel occlusion following randomised controlled trials performed largely in high-income countries. Limited data exists on its effectiveness in the setting of low-and-middle-income countries. We aimed to evaluate the safety and efficacy of MT in a tertiary level public hospital in Cape Town, South Africa. Methods Patients with acute ischaemic stroke presenting consecutively to Groote Schuur Hospital between 1 January 2018 to 1 January 2022 with proximal intracranial occlusion in the anterior circulation treated with MT within 6 h from onset using computed tomography (CT) and CT angiography imaging-based protocols were evaluated. Demographic, clinical, radiological and procedural data were obtained from the stroke unit database. Recanalisation was evaluated post-procedure by modified Treatment in Cerebral Infarction score (mTICI). Functional independence (modified Rankin scores 0–2) and mortality at 90 days were also assessed. Results Thrombectomies were performed in 84 patients during the study period. The median age was 56 years (interquartile range, IQR) and 51% of participants were female. Median National Institute of Health Stroke Score was 18 and median baseline Alberta Stroke Programme Early CT score was 8. Bridging thrombolysis was given to 65% of participants. Median time from symptom onset to reperfusion was 339 min (IQR). Successful recanalisation (mTICI 2b/3) was obtained in 62%. At 90 days, 34% of participants gained functional independence and mortality was 34%. Conclusion This study demonstrated similar rates of recanalisation and functional independence to that seen in trials in high-income countries using basic imaging despite a higher mortality and longer median time to reperfusion. This data supports the effectiveness of MT in a tertiary level public hospital in South Africa despite the challenges of providing emergent stroke care in a resource-constrained setting.