bluuebunny/crossref_metadata_2025_split huggingface dataset:
A matter of time: the impacts of Covid-19 on marine biodiversity negotiations
Authors: Langlet Arne , Wanneau Krystel , Dunshirn Paul , Ruiz Rodríguez Silvia C. , Tessnow-von Wysocki Ina , B.M.Vadrot Alice 
Published: January 2023

Les négociations en personne du nouveau traité pour conserver et utiliser durablement la biodiversité marine au-delà des juridictions nationales (BBNJ) ont été interrompues par la pandémie du Covid-19 et ses confinements, à l’instar de nombreuses autres réunions internationales sur l’environnement. Dans le cas du BBNJ, les acteurs étatiques et non étatiques ont initié plusieurs formats d’échanges numériques et de ‘sites’ virtuels de négociation pour continuer ces relations multilatérales sur une période de deux ans. Pour explorer l’impact de ce ‘tournant numérique’ dans les processus de création d’accords multilatéraux environnementaux, nous avons adapté les méthodologies que nous avions utilisées auparavant pour étudier les négociations en personne et ainsi conduit deux questionnaires en ligne et une ethnographie politique critique. Deux questions générales ont guidé notre recherche : comment les négociations sont-elles devenues numériques et quels ont été les impacts de ce tournant numérique ? Nous analysons les impacts à plusieurs niveaux et les discutons par le biais de trois dimensions temporelles : la temporalité comprise comme une vitesse, une période, et un élan. Nos résultats indiquent que, premièrement, les acteurs non étatiques ont participé plus activement dans les formats en ligne pour maintenir le rythme des négociations ; deuxièmement, les individus ont perçu cette période supplémentaire de temps — pendant laquelle ils ne pouvaient que communiquer en ligne ‘en attendant’ le retour des négociations en personne —comme étant certes négative mais dont l’expérience était partagée ; et troisièmement, les formats en ligne ont assuré que l’élan des négociations ne s’éteigne pas pendant la crise du Covid-19 —et ainsi évité un échec du processus général de négociation.
Les aires marines protégées de l’Autorité internationale des fonds marins : la négociation environnementale et l’extraction minière
Authors: Pires da Cruz Tiago 
Published: January 2023

L’Autorité Internationale des Fonds Marins (AIFM) est mandatée pour réguler le développement de l’industrie minière des grands fonds marins au-delà des juridictions nationales. Elle développe des politiques environnementales dès ses débuts en 1996. Mais celles-ci demeurent liées à son mandat minier. La négociation internationale environnementale qui se déroule de 2007 à 2012 avec des acteurs externes met en lumière des enjeux entre sciences/politiques, experts/décisionnaires ou développement industriel/environnement. Elle se développe autour d’« Aires Marines Protégées » (AMP), des instruments de conservations par zonage à la popularité croissante. Leur visée étant d’exclure les activités minières de vastes zones de haute mer, le projet semble aller à l’encontre du mandat extractif de l’organisation internationale. Mais le format de la négociation va les rendre compatible avec le projet de laisser ouvert un horizon « durable » pour les mines des grands fonds marins.
Construction-déconstruction de la comptabilité publique
Authors: Kott Sébastien 
Published: January 2023

La comptabilité est une construction humaine, il en va de même dans le secteur public. Néanmoins, la comptabilité publique fut longtemps comprise et pensée sous un angle juridique ce qui a conduit à une grande confusion. Le décret GBCP de 2012 propose enfin une définition fonctionnelle de la comptabilité correspondant à ce qu’elle est plus qu’à son régime juridique. Cela permet de déconstruire la notion pour la mettre en perspective avec deux notions proches : comptes publics et comptabilité des entités publiques.
Trois méthodes comptables complémentaires pour mettre les problèmes écologiques au cœur de la chose publique
Authors: Feger Clément , Levrel Harold , Rambaud Alexandre 
Published: January 2023

Ce papier met en avant la pertinence et l’importance du développement de cadres comptables écologiques nouveaux à même de contribuer aux multiples efforts de transformation de notre économie en un système qui maintient et restaure efficacement la biosphère. Trois méthodes de comptabilité écologique sont présentées, s’établissant respectivement au niveau national (les coûts écologiques non payés), des organisations (le modèle CARE), et de la gestion collective des écosystèmes sur les territoires (la comptabilité de gestion écosystème-centrée). Nous montrons en quoi ces méthodes partagent un socle théorique commun en ce qu’elles sont toutes les trois ancrées en « soutenabilité forte » et privilégient des approches par les coûts de préservation/restauration des écosystèmes. Nous concluons en insistant sur la complémentarité de ces approches et la nécessité d’avancer sur les chantiers d’articulation déjà engagés dans le cadre des travaux de la chaire Comptabilité écologique.
La LOLF 2.0 : du cadre budgétaire à l’encadrement des finances publiques. Une analyse de la loi organique du 28 décembre 2021 relative à la modernisation de la gestion des finances publiques
Authors: Mordacq Frank 
Published: January 2023

La loi organique du 28 décembre 2021 relative à la modernisation de la gestion des finances publiques modifie substantiellement la loi organique du 1 er août 2001 relative aux lois de finances en y intégrant un pilotage pluriannuel renforcé des finances publiques destiné à mieux surveiller l’exécution des engagements de l’État pris dans les lois de programmation éponymes. Elle comporte par ailleurs des dispositions permettant une application plus rigoureuse des principes budgétaires au regard des pratiques de la LOLF et accentue les demandes d’informations et les pouvoirs de vote et de contrôle du Parlement sur les finances publiques. Cependant les règles de gouvernance se heurtent à des limites juridiques et politiques et les exigences d’information du Parlement ne peuvent porter atteinte à la répartition des pouvoirs entre l’exécutif et le législatif en matière de finances publiques.
Strasbourg, « capitale de l’Europe » : un autre rapport du citoyen aux institutions européennes ?
Authors: Foret François 
Published: January 2023

Strasbourg comme « capitale européenne » constitue un terrain privilégié d’étude de la socialisation des citoyens à l’UE pour tester deux hypothèses. D’une part, la proximité des institutions européennes peut favoriser des interactions directes. D’autre part, le fait de vivre au centre symbolique du système européen peut fonctionner comme une gratification identitaire renforçant l’identification et le soutien à l’UE. Les résultats d’un sondage auprès d’un échantillon représentatif de Strasbourgeois suggèrent un effet modéré des deux facteurs proximité et centre symbolique, effet qui n’occulte cependant pas les discriminations socioéconomiques et culturelles habituelles du rapport à l’Europe des individus.
Lou Andreas-Salomé l’hérétique : « L’Éros n’a jamais de fin »
Authors: Ardeven François 
Published: January 2023

De toutes les « filles de Freud », de ces femmes qui ont été ravies dans le foyer du professeur viennois, Lou Andreas-Salomé se détache, selon son mot, « par son tempérament ». De la même génération que Freud, et en somme, son égale, après avoir participé à la vie de l’esprit avec Nietzsche et Rilke, elle rencontre Freud à Weimar en 1911. Vingt ans plus tard, elle lui écrit une lettre ouverte pleine de ferveur mais « hérétique » comme elle dit. Sur la mort, qu’il ne faut pas imaginer dans une passivité sans sujet, ou sur la question du narcissisme primaire à toujours considérer actif tout au long de la vie, Lou Andreas-Salomé manifeste son désaccord, celui d’une femme qui ne se fait pas tout à fait à l’esprit de conquête et de progrès. Enfin, elle ne se range pas en art à la théorie freudienne de la fécondité des refoulements. Trois hérésies qui font de Lou Andreas-Salomé une des plus grandes freudiennes de son temps.
Two unusual presentations of vitamin B12 Deficiency.
Authors: Edirisinghe Udara Priyadarshani , Silva F. H. D. Shehan 
Published: January 2023

Vitamin B12, a water-soluble vitamin is important in DNA synthesis. Inadequate intake of animal foods and pernicious anaemia (loss of intrinsic factor due to autoimmune atrophic gastritis) are known to be the most common causes of severe deficiency worldwide (1).
Although most of the patients with deficiency have only mild haematological findings, very few presents present with symptomatic pancytopenia, severe anaemia (haemaglobin
Identifying potential ligand molecules EGFR mediated TNBC targeting the kinase domain-identification of customized drugs through in silico methods
Authors: Vyshnavi Hima , Namboori Krishnan 
Published: January 2023

Background and Purpose:
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer in which three hormone receptors are negative. This work aimed at identifying customized potential molecules inhibiting epidermal growth factor receptor (EGFR) by exploring variants using the pharmacogenomics approaches.

Experimental approach:
The pharmacogenomics approach has been followed to identify the genetic variants across the 1000 genomes continental population. Model proteins for the populations have been designed by including genetic variants in the reported positions. The 3D structures of the mutated proteins have been generated through homology modeling. The kinase domain present in the parent and the model protein molecules has been investigated. The docking study has been performed with the protein molecules against the kinase inhibitors evaluated by the molecular dynamic simulation studies. Molecular evolution has been performed to generate the potential derivatives of these kinase inhibitors suitable for the conserved region of the kinase domain. This study considered variants within the kinase domain as the sensitive region and remaining residues as the conserved region.

Findings/Results:
The results reveal that few kinase inhibitors interact with the sensitive region. Among the derivatives of these kinase inhibitors molecules, the potential kinase inhibitor that interacts with the different population models has been identified

Conclusions and implications:
This study encompasses the importance of genetic variants in drug action as well as in the design of customized drugs. This research gives way to designing customized potential molecules inhibiting EGFR by exploring variants using the pharmacogenomics approaches.
A comparative study of the arazyme-based fusion proteins with various ligands for more effective targeting cancer therapy
Authors: Mehrab Rezvan , Sedighian Hamid , Sotoodehnejadnematalahi Fattah , Halabian Raheleh , Fooladi Abbas Ali Imani 
Published: January 2023

Background and purpose:
Recently, the use of immunotoxins for targeted cancer therapy has been proposed, to find new anticancer drugs with high efficacy on tumor cells with minimal side effects on normal cells. we designed and compared several arazyme (AraA)-based fusion proteins with different ligands to choose the best-targeted therapy for interleukin 13 receptor alpha 2 (IL13Rα2)-overexpressed cancer cells. For this purpose, IL13Rα2 was selected as a receptor and IL13 and IL13.E13K were evaluated as native and mutant ligands, respectively. In addition, Pep-1 and A2b11 were chosen as the peptide ligands for targeted cancer therapy.

Experimental approach:
Several bioinformatics servers were used for designing constructs and optimization. The structures of the chimeric proteins were predicted and verified by I-TASSER, Q-Mean, ProSA, Ramachandran plot, and Verify3D program. Physicochemical properties, toxicity, and antigenicity were predicted by ProtParam, ToxinPred, and VaxiJen. HawkDock, LigPlot+, and GROMACS software were used for docking and molecular dynamics simulation of the ligand-receptor interaction.

Findings/Results:
The in silico results showed AraA-A2b11 has higher values of confidence score and Q-mean score was obtained for high-resolution crystal structures. All chimeric proteins were stable, non-toxic, and non-antigenic. AraA-(A(EAAAK)4ALEA(EAAAK)4A)2-IL13 retained its natural structure and based on ligand-receptor docking and molecular dynamic analysis, the binding ability of AraA-(A(EAAAK)4ALEA(EAAAK)4A)2-IL13 to IL13Rα2 was sufficiently strong.

Conclusion and implications:
Based on the bioinformatics result AraA-(A(EAAAK)4ALEA(EAAAK)4A)2-IL13 was a stable fusion protein with two separate domains and high affinity with the IL13Rα2 receptor. Therefore, AraA-(A(EAAAK)4ALEA(EAAAK)4A)2-IL13 fusion protein could be a new potent candidate for target cancer therapy.
Effect of metformin alone and in combination with etoposide and epirubicin on proliferation, apoptosis, necrosis, and migration of B-CPAP and SW cells as thyroid cancer cell lines
Authors: Ghavami Ghazaleh , Kiasari Ramin Ebrahimi , Pakzad Faezeh , Sardari Soroush 
Published: January 2023

Background and purpose:
There has not been a comprehensive study on the simultaneous effects of metformin, etoposide, and epirubicin on thyroid cancer cells. Hence, the current research proposed the in vitro study on the effect of metformin alone and in combination with etoposide and epirubicin on the rate of proliferation, apoptosis, necrosis, and migration against B-CPAP and SW-1736 cells as thyroid cancer cell lines.

Experimental approach:
MTT-based proliferation assay, combination index method, flow cytometry, and scratch wound healing assays were used to evaluate the simultaneous effects of the three approved drugs against thyroid cancer cells.

Findings/Results:
This study showed that the toxic concentration of metformin on normal Hu02 cells was more than 10 folds higher than B-CPAP and SW cancerous cells. Metformin in combination with epirubicin and etoposide could increase percentages of B-CPAP and SW cells in early and late apoptosis and necrosis phases in comparison with their single concentrations, significantly. Metformin in combination with epirubicin and etoposide could arrest the S phase in B-CPAP and SW cells, significantly. Metformin in combination with epirubicin and etoposide could reduce ~100% migration rate, whereas single concentrations of epirubicin and etoposide could reduce ~50% migration rate.

Conclusion and implication:
Combined treatment of metformin with anticancer drugs epirubicin and etoposide can increase the mortality in thyroid cancer cell lines and reduce the toxicity of these drugs on the normal cell line, which could be the starting point for proposing a new combination strategy in the therapy of thyroid cancer to induce more potency and reduce acute toxicity.
Psychological Impact of COVID-19 on Health-Care Workers in Southern India
Authors: Shaik Parveen Sultana , Halder Niharika , Thota Saranya , Nachu Sneha , Bhavani Vasamsetti Divya , Pavani Nijampatnam P. M. 
Published: January 2023

Background:
The study aims to uncover some of the relevant concerns, with a specific emphasis on psychological and mental status evaluation, as well as a few suggested coping mechanisms.

Materials and Methods:
A cross-sectional, observational study conducted on medical, dental, and nursing from all over India. The questionnaire, which consisted of 19 questions, was designed to determine the health-care professionals’ awareness of the WHO guidelines. Collected data were computed with SPSS version 25 and analyzed using descriptive statistics, independent t-test and Chi-square test, Pearson correlation, and one-way ANOVA.

Results:
Medical (4.23 ± 0.645) health-care personnel have higher mean stress levels than nursing (3.16 ± 0.458) and dental (2.2 ± 0.953) health-care workers (HCWs) (P = 0.0001). In terms of work experience, 6–10 years (3.35 ± 1.13) have higher stress levels than 1–5 years and >10 years (P = 0.005).

Conclusion:
This study uncovered a high pervasiveness of discerning stress among HCWs during the COVID-19 pandemic, which afflicted all workers despite the demographic status.
Recent advancements in critical care: Part I
Authors: Gopal Palepu B. , Karim Habib Md Reazaul , Karthekeyan Ranjit , Raphael Paul Ovungal , Tiwaskar Shilpa , Vaidyanathan R 
Published: January 2023

ABSTRACTMedical colleges are now developing or refurbishing their anaesthesia intensive care units. In most teaching colleges, the residency post includes working in the critical care unit (CCU). Critical care is a rapidly evolving and popular super-speciality for postgraduate students. In some hospitals, anaesthesiologists play a key role in the management of the CCU. As perioperative physicians, all anaesthesiologists should be aware of the recent advancements in diagnostic and monitoring gadgets and investigations in critical care so that they may manage perioperative events effectively. Haemodynamic monitoring gives us warning signs about the change in the internal milieu of the patient. Point-of-care ultrasonography helps in rapid differential diagnosis. Point-of-care diagnostics give us instant bed-side information on the condition of a patient. Biomarkers help in confirming diagnosis, in monitoring, treatment, and providing prognosis. Molecular diagnostics guide anaesthesiologists in providing specific treatment to a causative agent. This article touches upon all of these management strategies in critical care and attempts to put forth the recent advancements in this speciality.
Recent advances in geriatric anaesthesia
Authors: Mahender Anuradha , Chavan Surekha S. , Saroa Richa , Chauhan Meenal 
Published: January 2023

ABSTRACT
The World Health Organization defines healthy ageing as ‘the process of developing and maintaining the functional ability that enables well-being in older age’. This functional ability is the characteristic of the individual’s own physical and mental status influenced by the environmental and socio-economic factors. Preoperative preparation of the elderly patients includes functional assessment to identify preexisting cognitive impairment or cardio-pulmonary reserve, frailty, nutrition, polypharmacy and anti-coagulation issues. Intraoperative management includes anaesthetic mode and pharmacology, monitoring, intravenous fluid and transfusion management, lung protective ventilation and hypothermia. Postoperative checklist includes perioperative analgesia, postoperative delirium and cognitive dysfunction.
Update on preoperative evaluation and optimisation
Authors: Jindal Parul , Patil Vidya , Pradhan Rajeev , Mahajan Hitendra C. , Rani Amutha , Pabba Upender Gowd 
Published: January 2023

ABSTRACT
The patients presenting for surgery today often belong to the extremes of age, have multiple co-morbidities, and undergo complex surgeries. This makes them more prone to morbidity and mortality. A detailed preoperative evaluation of the patient can contribute to reducing this mortality and morbidity. There are various risk indices and validated scoring systems and many of them need to be calculated using preoperative parameters. Their key objective is to identify patients vulnerable to complications and to return them to desirable functional activity as soon as possible. Any individual undergoing surgery should be optimised preoperatively, but special considerations should be given to patients with comorbidity, on multiple drugs, and undergoing high-risk surgery. The objective of this review is to put forth the latest trends in the preoperative evaluation and optimisation of patients undergoing noncardiac surgery and emphasise the importance of risk stratification in these patients.
Recent advances in research, training and teaching in anaesthesia and critical care
Authors: Hemantkumar Indrani , Sanwatsarkar Sadhana , Narendra Babu MC , Kaur Sarvjeet , Dogra Neeti , Bajwa Sukhminder Jit Singh 
Published: January 2023

ABSTRACT
Teaching and learning in anaesthesia and critical care has traditionally included seminars, journal clubs and clinical teaching in the operation theatre. The aim has always been to ignite the spark of thinking and self-directed learning in the students. The process of ‘dissertation preparation’ introduces basic knowledge and interest in research in the postgraduate student. All this is followed by an examination at the end of the course including the theory and practical assessment in the form of long and short case discussions and table viva-voce. The National Medical Commission in 2019 introduced the competency-based medical education curriculum for anaesthesia postgraduates. This curriculum focuses on structured teaching and learning. It has specific learning objectives in theoretical knowledge, skills and attitude development. The building up of communication skills has been given due importance. Though research in anaesthesia and critical care is steadily progressing, much work needs to be done on its improvement.
Recent trends in chronic pain medicine
Authors: Malhotra Naveen , Joshi Muralidhar , Dey Samarjit , Sahoo Rajendra , Verma Sidharth , Asish K 
Published: January 2023

ABSTRACT
Chronic pain presents as an unequalled challenge for physicians, owing to the complexity of biochemical and biological pathways involved in pain transmission and high variability of pain perception among individuals. Often, there is an inadequate response to conservative treatment, and opioid treatment has its own drawbacks, such as side effects and opioid dependence. Hence, novel strategies have evolved for the effective and safe management of chronic pain. Radiofrequency technique, regenerative biomaterial, platelet-rich plasma, mesenchymal stem cells, reactive oxygen species scavenger nanomaterial, ultrasound-guided interventional pain management procedures, endoscopic spinal procedures, vertebral augmentation therapy, and neuromodulation are some of the promising and upcoming modalities in the armamentarium of pain physicians.
Newer frontiers in onco-anaesthesia and palliative medicine
Authors: Balakrishnan Kalpana , Goswami Jyotsna , Koshy Rachel C. , Hariharan Uma , Srivastava Divya , Salgaonkar Sweta 
Published: January 2023

ABSTRACT
Despite an increase in knowledge on the biology of cancer and newer therapeutic modalities, the incidence and mortality of cancer continue to rise. Interventions to enhance perioperative outcomes in cancer is a growing research area that targets early recovery and initiation of cancer-specific treatment. Increasing mortality in non-communicable diseases such as cancer mandates an integrated palliative care for these patients to achieve the best possible quality of life. The aim of this review is to discuss in brief the advancements in onco-anaesthesia and palliative medicine that have helped improve oncological outcomes and the quality of life of patients.
Recent advances in anaesthesia for intrauterine and foetal surgery
Authors: Nath Gita , Subrahmanyam M , Jayanthi R , Singh Ranju , Ramesh S , Ahuja Vanita 
Published: January 2023

ABSTRACT
Advances in prenatal diagnostic techniques have enabled early detection of potentially correctable foetal anomalies. Here, we summarise recent developments in anaesthesia for foetal surgery. Types of foetal surgery include minimally invasive, open mid-gestational and ex-utero intrapartum treatment (EXIT) procedures. Foetoscopic surgery avoids hysterotomy, with risk of uterine dehiscence, preserving the possibility of subsequent vaginal delivery. Minimally invasive procedures are performed under local or regional anaesthesia; open or EXIT procedures are usually done under general anaesthesia. Requirements include maintenance of uteroplacental blood flow, and uterine relaxation to prevent placental separation and premature labour. Foetal requirements include monitoring of well-being, providing analgesia and immobility. EXIT procedures require maintenance of placental circulation till the airway is secured, requiring multidisciplinary involvement. Here, the uterine tone must return after baby delivery to prevent major maternal haemorrhage. The anaesthesiologist plays a crucial role in maintaining maternal and foetal homeostasis and optimising surgical conditions.