bluuebunny/crossref_metadata_2025_split huggingface dataset:
#5576 SYSTEMATIC REVIEW AND META-ANALYSIS OF THE SAFETY AND EFFICACY OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR THE MANAGEMENT OF POSTPARTUM PAIN
Authors: Jain Arunima , Heath Lauren , Tian David , Siritharan Sai , Natali Florensia , Jayasekara Mudith , Thurgate Lauren , Seeho Sean , Delaney Anthony , Mather Amanda 
Published: June 2023

Abstract

Background and Aims
Effective pain management is critical for postpartum recovery. While commonly prescribed, systematically-reviewed data regarding efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) are limited. Moreover, guidelines suggest avoiding NSAIDs in women with hypertensive disorders of pregnancy (HDP) due to risks of hypertension and adverse events (AE). However, these AE have not been consistently observed in cohort studies and randomised controlled trials (RCTs) following postpartum NSAID use. This systematic review aims to provide further insight into the postpartum safety and efficacy of NSAIDs.

Method
A systematic review of eight databases and four clinical trial registries was conducted in July 2020 (PROSPERO Protocol CRD42020196054). RCTs which assessed the safety and/or efficacy of NSAIDs in postpartum women after the year 2000 were included. The primary outcome was incidence of hypertension, with secondary outcomes categorised into three groups: hypertension, secondary safety and efficacy. Data were tabulated and analysed using R (version 4.0.2). Due to heterogeneity in study design, NSAIDs were analysed in a single group and compared with other medications (including paracetamol, opioids, and local anaesthetics) grouped based on mechanism to facilitate meta-analysis. Risk of bias was assessed using the RoB 2 tool with a plan to assess quality of evidence for the primary outcome.

Results
12,172 records were identified with the inclusion of 92 RCTs. Eight studies, with four that included women with HDP, reported hypertension-related data (Table 1). The primary outcome was included in one RCT. Secondary safety outcomes such as acute kidney injury or eclampsia were not reported. The odds of nausea, vomiting and sedation were similar between groups. NSAIDs were effective when compared with placebo, as assessed by mean differences (MD) in visual assessment scores (VAS) at 12 hours (MD -1.57, 95% confidence intervals (CI) -2.47 to -0.66), 24 hours (MD -0.82, 95% CI -1.42 to -0.22) and need for additional analgesia (odds ratio 0.17, 95% CI 0.05 to 0.61). There were no significant differences in VAS between NSAIDs and other comparators at 12 and 24 hours. Further interpretation of results is limited due to heterogeneity in intervention and comparator groups, inclusion criteria and reported outcomes.

Conclusion
Our study confirms the efficacy of NSAIDs for postpartum pain, but current data are inconclusive regarding the risk of developing hypertension. Available data do not demonstrate trends toward AE although further research is required to determine long term, clinically-relevant outcomes to guide decision making.
#5987 EPIDEMIOLOGICAL AND CLINICAL PROFILE OF PATIENTS REQUIRING EMERGENCY HEMODIALYSIS
Authors: Hatem Mhenni , Khadhar Meriam , Sarra Hadded , Jerbi Mouna , Gaied Hanene , Aoudia Raja , Goucha Rim 
Published: June 2023

Abstract

Background and Aims
Dialysis can be either programmed or performed in an emergency context, which complicates the management of patients. Our objective was to study the indications as well as the epidemiological, clinical and biological elements of dialysis emergencies.

Method
This is a retrospective study conducted over a period of 5 months from March 2022 to September 2022 in the nephrology department of the Mongi Slim Hospital La Marsa including patients having had emergency hemodialysis sessions

Results
We collected a total of 32 cases with an average age of 65 years, ranging from 30 years to 93 years and a sex ratio at 1.06.
The majority of patients were transferred from the emergency department (69%) and secondarily from the nephrology (6%) and cardiology (6%) departments. Sixty-five percent of the patients had arterial hypertension, 53% were diabetic, 37% had chronic kidney disease, 28% had cardiovascular complications, and 41% had an active infection with a biological inflammatory syndrome.
Emergency hemodialysis was indicated for severe metabolic acidosis in 50% of the cases, threatening hyperkalemia in 41% of the cases, uremic syndrome in 28% of cases, anuria in 28% of cases, and acute lung edema resistant to medical treatment in 19% of cases. Indeed, 47% of the patients had a single dialysis emergency and 53% of them were dialyzed for several interrelated indications.
The vascular approach was mainly femoral catheter in 84% of the cases followed by arteriovenous fistula in 13% and jugular catheter in 3%. The average session duration was 3.5 hours with good hemodynamic tolerance for the majority of patients. Five patients required a blood transfusion.

Conclusion
Severe metabolic acidosis and threatening hyperkalemia were the main indications for emergency hemodialysis. Unfortunately, the majority of our patients were dialyzed via a femoral catheter. It is therefore recommended to insist on the necessity of early preparation of patients for dialysis as early as stage 4 of chronic kidney disease if the patient obviously chooses hemodialysis as the preferred method of epuration.
#6213 RISK FACTORS FOR END-STAGE RENAL DISEASE IN IGA NEPHROPATHY
Authors: Sahar Bouassida , Khadhar Meriam , Sarra Hadded , Jerbi Mouna , Hanen Gaied , Raja Aoudia , Rym Goucha 
Published: June 2023

Abstract

Background and Aims
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular nephropathy worldwide and one of the principal causes of chronic kidney disease. The presentation of this nephropathy is different between ethnic groups. The aim of our work is to describe the clinical, biological, and pathological symptoms of maghrebian patients diagnosed with IgAN.

Method
We conducted a retrospective descriptive study over 46 years from 1975 and 2021. This study included 213 patients with renal biopsy-proven IgAN whose clinical, biological, and pathological data were assessed and classified according to the Oxford classification.

Results
The mean age of the patients was 34.48 [15-80] with male predominance (sex ratio=1.77). Thirty-nine patients had a family history of kidney disease. 109 patients (51%) had hypertension. The median proteinuria was 2.6 g/24 h [0-46.17 g/24 h]. Nephrotic proteinuria(&gt;3 g/24h) was found in 98 patients (46%). The initial median glomerular filtration rate was 33.9 ml/min/1,73 m²SC. At the end of the follow-up, it was 23.7 ml/min/1.73 m²SC. Renal biopsy was performed in all the cases. The lesions observed in optical microscopy were mesangial proliferation M1 (63.8%), endocapillary proliferation E1(8.5%), glomerulosclerosis S1 (71.4%), interstitial fibrosis or tubular atrophy T1-T2 (72.8%) and crescents C1 (16.9%). Fifty-two percent of the patients were treated with ACE inhibitors or ARAII.47.9% of our population reached end-stage kidney disease and required dialysis. Only 23 patients (10.8%) had a kidney transplant.

Conclusion
The treatment of IgA nephropathy is based on early diagnosis, hence the need for a screening strategy to prevent the discovery of this nephropathy in an advanced stage.
#6282 MAKING DECISION OF VASCULAR ACCESS TYPE BASED ON UPPER ARM DOPPLER PARAMETERS AMONG INCIDENT HEMODIALYSIS PATIENTS: A SINGLE CENTER EXPERIENCE
Authors: Jankovic Aleksandar , Rajić Sofija , Davidovic Zeljko , Stopić Bojan , Djuric Petar , Pešić Snezana , Naumovic Radomir 
Published: June 2023

Abstract

Background and Aims
Functional vascular access (VA) remains one of the most important problems related to successful hemodialysis (HD) treatments. Pivotal issue related to inadequate vascular access is decision making process of which type of VA should be created at start. Therefore, the aim of our study is to examine possible impact of Doppler examination of upper arm on decision of VA type creation.

Method
During 5 year period (January 2018th- December 2022th), 260 patients started hemodialysis in our department. Among them, 18 died during the first three months after HD was started, 3 were transferred to other hospitals for chronic HD program and 5 have created vascular access in other hospitals. So, we analyzed data for 234 patients (No=150, 63.6% males, mean age 62.6±13.8) which vascular access were created in our Center. We have divided them into two groups (Group A-patients with arterio-venous fistula (AVF) as first created VA and group B-patients with arterio-venous graft (AVG) or permanent central venous catheter (pCVK) as first created VA. From medical records, we have collected demographic data, type of created vascular access, Doppler parameters of upper arm and laboratory findings.

Results
Out of 234 patients, in Group A were167 patients (male No=109, 65.2%, mean age 61.0 years±13.8), while in group B were 67 patients(male No=40, 59.7% mean age 66.8 years±13.2). In table 1, demographic, laboratory and Doppler data is presented. We found that in Group A patients are statistically younger (61.0 years ±13.8 vs 66.8 years ±13.2, P = .004) and their vena cephalica (2.9mm± 2.5 vs 1.9mm±0.1, P = .000) and arteria radialis (2.2mm±0.4 vs 1.9mm±0.1, P = .002) are with better diameters. Also, their protein levels were statistically lower (69±9 vs 78±3, P = .036) and CRP levels higher (21.2±35.3 vs 8.1±2.1, P = .000) compared to Group B. Binary logistic regression revealed that there are no statistically significant variables that could impact decision to create AVF, but larger diameter of vena cephalica increase this decision over 13 fold (OR 13.497, CI 0.706-257.868, P = .084), and diameter of arteria radialis 17 fold (OR 17.073, CI 0.372-784-182, P = .146).

Conclusion
Diameteres of vena cephalica and arteria radialis could be the main variables in the planning of type of vascular access.
#6463 IMPLEMENTATION OF CLINICAL ALARM SYSTEM IS ASSOCIATED WITH REDUCTION OF THE RISK OF INTRADIALYTIC HYPOTENSION
Authors: Lin Hsuanming , Liu Chi Yuan , Hu Hsiang Wei , Chen Kuanyu , Chu Jennie Ting Hsuan , Un Chi Hin , Wang Jian-An 
Published: June 2023

Abstract

Background and Aims
Intradialytic hypotension (IDH) plays an essential role in hemodialysis. IDH prevalence can be up to 8% to 40% [1], according to research. Furthermore, research shows that IDH positively correlates with severe complications such as non-occlusive mesenteric ischemia[2], critical limb ischemia[3] and tissue ischemia, which leads to irreversible damage, even increasing the chance of infection. Many causes and risk factors result in IDH, such as excessive weight gain during dialysis, cardiovascular dysfunction, and improper use of blood pressure-lowering drugs[1]. Therefore, it still relies on experienced medical professionals to monitor patients’ blood pressure to beware of the risk of developing IDH. However, this increases the workload on medical professionals and does not provide standard or more objective early warning indicators of hypotension for new medical professionals.

Method
Selection of experimental and control group: In this study, we included 81 subjects that received hemodialysis in Tainan City Municipal Annan Hospital from January 2021 to August 2022. The control group was retrospective data collected from January 2021 to August 2021. Then, from January 2022 to August 2022, we implemented our IDH predicting system and took subjects’ data from this interval as the experimental group to compare the incidence of IDH with the control group.
IDH prediction system monitoring interface: After integrating with the hemodialysis dataset, our prediction system will predict patients’ systolic pressure and the likelihood of IDH in the next 30 minutes. As soon as the system detects that the patient will encounter hypotension, it sends warning signals, blood pressure and IDH incidence probability predictions to the monitoring interface to alert medical professionals. Furthermore, our system also supports multi-bed monitoring, which can significantly increase the efficiency of monitoring during hemodialysis.

Results
After implementing the IDH prediction system, the outcome yielded an IDH incidence of 6.12% in August 2022. Compared to the control group, when the IDH system was not yet implemented, which yielded an IDH incidence of 9.34%, it showed a reduction of 34.5% in IDH cases. Furthermore, the average reduction in IDH rate each month was 12%.

Conclusion
The present study demonstrated that implementing the IDH predicting model may efficiently reduce the incidence of IDH. However, along with the IDH warning multi-bed monitoring interface, medical professionals must develop a standard procedure to deploy when noticing the warning signals. As a result, this may further reduce the incidence of IDH during hemodialysis sessions.
#6814 A NEW SORBENT DEVICE FOR MULTIPLE CLINICAL PURPOSES: CURRENT EVIDENCE AT A PRIVATE HOSPITAL IN MEXICO
Authors: Mier Jesus , Merino Ruben 
Published: June 2023

Abstract

Background and Aims
Adsorption is an extracorporeal technique utilized for blood purification, it also complements convection and diffusion for solute removal. Since 1991 we had used blood purification techniques, over the years, new adsorption cartridges had been developed, the new ones involving treatment for inflammatory conditions, chronic uremic symptoms and autoimmune diseases. HA130, HA230, and HA330 (Jafron, Zhuhai City, China) are among the widely used adsorption cartridges in China. We report highlights of the use of hemoperfusion using HA130 cartridges in the Mexican population cohorts in the context of multiple chronic inflammatory conditions in order to support evidence of effectiveness and safety.

Method
We retrospectively analyzed the medical records of 14 critically ill patients in the context of chronic inflammatory conditions such as acute kidney injury in chronic kidney disease, acute lung injury due to SARS-COV-2 infection and sepsis. Hemoperfusion in addition to standard therapy (fluid resuscitation, vasopressors, antimicrobial therapy and ventilatory support) resulted in the improvement of inflammatory substances levels when compared to standard therapy alone. Out of the 14 patients, 7 patients used HA130 cartridges and 7 patients with standard therapy alone.

Results
There were no significant side effects associated with HA130 cartridge use. HA 130 cartridges were found to be effective in reducing uremic symptoms in chronic hemodialysis patients, improvement of pruritus score and decreased parathyroid hormone and phosphate product (p&lt;0.5) when compared to HD alone, creatinine (MARS: −24 μmol/L, −19.5 to −10.46, p &lt; 0.001; SPAD: −2 μmol/L, −9.0 to +7.0/L, p = 0.314) and urea (MARS: −0.9 mmol/L, −318 to −0.189, p = 0.024; SPAD: −0.1 mmol/L, −1.0 to +0.68, p = 0.523). 66.6% of cost-effectiveness when compared to standard therapy.

Conclusion
In the group of patients that used HA130 cartridges we found statistically significant (p &lt;0.05) reduction of pruritus score, PTH, phosphate product, creatine and urea when compared to the group of patients with standard therapy alone. The development in new cartridges technology allows more wide applications for renal patients. As we expand to involve other indications for this therapy there is cost-effectiveness improvement for the patients.More studies in different clinical settings are needed in order to achieve adsorption therapy national recommendations. We also found that the HA130 cartridges are effective in reducing uremic symptoms and microinflammatory status in acute kidney injury in chronic kidney disease patients due to the elimination of middle and small molecule uremic toxins and inflammatory mediators and endotoxins. This may translate as an improvement of quality of life and survive rates in patients with chronic hemodialysis, even though more studies are needed in order to prove this assumption.
Diel, seasonal and vertical changes in the abundance, biomass and community structure of pelagic polychaetes at the subtropical station S1 in the western North Pacific: comparison with the results from the subarctic station K2
Authors: Amei Kanako , Dobashi Ryo , Kitamura Minoru , Yamaguchi Atsushi 
Published: June 2023

Abstract
Information on pelagic polychaete community structure in the western North Pacific is available for the subarctic region (Station K2) but not for the subtropical region. Hence, we analyzed day–night vertically stratified samples collected in eight layers within the first 1000 m of the water column during four seasons in 1 year, using the same sampling method as St. K2, at the subtropical region (Station S1). At St. S1, 27 species of pelagic polychaetes belonging to 13 genera and six families were identified. The annual mean abundance was 35.0 ind. 1000 m−3 and the biomass was 17.3 mg WW 1000 m−3. At St. S1, the numbers of genera and species were higher and the annual mean abundance and biomasses were much lower than St. K2. The pelagic polychaetes often peaked in the mesopelagic layer at St. K2, with the carnivores and particle feeders peaking in the epipelagic and mesopelagic layers, respectively. At St.S1, the carnivorous species predominated throughout the entire water column, and were most abundant in the epipelagic layer. Thus, In the western Pacific Ocean, the subarctic pelagic polychaete community structure changed vertically with feeding ecology. On the other hand, the subtropical community may be adapted to conditions of high irradiance and light transmission.
When the construction of police legitimacy backfires? Emotion expression management in times of the erosion of the rule of law
Authors: Rak Joanna 
Published: June 2023

AbstractEmotion management in relation to police legitimacy during the pandemic in Poland offers an illustrative case study of backfire mechanisms in times of the erosion of the rule of law. Grounded in social constructionism, the study uses qualitative frame analysis to determine: what emotion management strategies embedded in discursive frames were used by the police and the state to build and rebuild police legitimacy during the pandemic? Why did they backfire? Masking, a strategy negative in valence, backfired. Ignoring emotions experienced by officers in frames constructed to gain legitimacy widened the rift between police and ordinary people. For the latter, it was equivalent to losing another public institution to the ruling state. If masking is the only strategy in use, law enforcement will likely be perceived negatively, and citizens will resist, impairing the ability of the police to perform its duties.
Familiality of the Intelligence Quotient in First Episode Psychosis: Is the Degree of Family Resemblance Associated With Different Profiles?
Authors: Murillo-García Nancy , Soler Jordi , Ortiz-García de la Foz Victor , Miguel-Corredera Margarita , Barrio-Martinez Sara , Setién-Suero Esther , Papiol Sergi , Fatjó-Vilas Mar , Ayesa-Arriola Rosa 
Published: June 2023

Abstract

Background and Hypothesis
There is uncertainty about the relationship between the family intelligence quotient (IQ) deviation and the risk for schizophrenia spectrum disorders (SSD). This study tested the hypothesis that IQ is familial in first episode psychosis (FEP) patients and that their degree of familial resemblance is associated with different profiles.

Study Design
The participants of the PAFIP-FAMILIAS project (129 FEP patients, 143 parents, and 97 siblings) completed the same neuropsychological battery. IQ-familiality was estimated through the Intraclass Correlation Coefficient (ICC). For each family, the intra-family resemblance score (IRS) was calculated as an index of familial similarity. The FEP patients were subgrouped and compared according to their IRS and IQ.

Study Results
IQ-familiality was low-moderate (ICC = 0.259). A total of 44.9% of the FEP patients had a low IRS, indicating discordancy with their family-IQ. Of these patients, those with low IQ had more schizophrenia diagnosis and a trend towards poorer premorbid adjustment in childhood and early adolescence. Whereas FEP patients with low IQ closely resembling their family-IQ were characterized by having the lowest performance in executive functions.

Conclusions
The deviation from the familial cognitive performance may be related to a particular pathological process in SSD. Individuals with low IQ who do not reach their cognitive familial potential show difficulties in adjustment since childhood, probably influenced by environmental factors. Instead, FEP patients with high phenotypic family resemblance might have a more significant genetic burden for the disorder.
Researcher roles in collaborative governance interventions
Authors: Peltola Taru , Saarela Sanna-Riikka , Kotilainen Juha M , Litmanen Tapio , Lukkarinen Jani , Pölönen Ismo , Ratamäki Outi , Saarikoski Heli , Salo Miikka , Vikström Suvi 
Published: June 2023

Abstract
While societies are facing complex problems involving multiple stakeholders and interdependencies, interest in collaborative governance as a potential solution is rising. Research-based interventions in policy, planning, and management processes have been introduced to test different approaches and tools for collaboration. The nature of these processes, tools, and approaches varies substantially, as do researchers’ cultures of making contributions to and in collaboration with society. This paper outlines the various possibilities and means for researchers to intervene in and explore steps towards collaborative governance. It utilises literature-based descriptions of potential roles for researchers and draws on insight from Finnish collaborative governance interventions in environmental decision-making. The conventional role of researchers as providers of knowledge was complemented with roles needed to foster favourable conditions for collaboration. Tensions regarding these roles show that collaborative governance requires a reflexive position from researchers, enabling them to adapt their ideas about collaboration to specific governance settings.
Social Reproduction Gone Wrong? The Citizenship Revocation and Rehabilitation of Young European Women Who Joined ISIS
Authors: Korteweg Anna , Yurdakul Gökçe , Sunderland Jillian , Streppel Marloes 
Published: June 2023

Abstract
Some European women who joined the Islamic State during the 2010s have had their citizenship revoked, which leaves them in a liminal state in camps at the Syrian border. Others have been able to return home, where they face prosecution and potential pathways to “rehabilitation.” This article turns to media discussions of two cases that have been extensively discussed in the media: Shamima Begum, a British national whose citizenship was revoked, and Laura Hansen, a Dutch national who was rehabilitated. Our analysis homes in on the symbolic dimension of social reproduction, showing how media representations of these two women as mothers, wives, and daughters play a critical role in media justifications of revocation and rehabilitation. We argue that media discourses create a gendered, racialized, and class-based conceptualization of citizenship unattainable to those whose social reproductive labor is deemed a threat to the nation-state.