bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and outcomes for hip fracture patients in an integrated orthogeriatric care model: a descriptive study of four discharge pathways with one-year follow-up
Authors: Salvesen Eirik Solheim , Taraldsen Kristin , Lønne Greger , Lydersen Stian , Lamb Sarah Elizabeth , Opdal Kjersti , Saltvedt Ingvild , Johnsen Lars Gunnar 
Published: February 2025

Abstract

Background
Orthogeriatric hospital care is recommended for hip fra cture patients, but differentiated hospital care has not been evaluated. The aim of this study was to describe physical performance and health-related quality of life for hip fracture patients 1-year after surgery in four treatment pathways. We also report changes in functional outcomes from baseline to 1-year follow-up together with readmission and mortality rates for each pathway.

Methods
We included 177 hip fracture patients aged 65 years or older from a single center in Norway. Participants were discharged home, to specialised rehabilitation, regular rehabilitation or nursing home based on orthogeriatric assessment of pre- and postfracture function, mobility level and Ac tivities of Daily Living. Outcome variables included Short Physical Performance Battery, EuroQol-5-dimension-5-level, Barthel-index, Lawton & Brody Instrumental Activities of Daily Living, Lawton & Brody Self-Maintenance Scale, readmission and mortality rates during follow-up.

Results
Participants discharged home and to specialised rehabilitation were younger and healthier than participants discharged to regular rehabilitation and nursing home. All groups had a clinically important improvement in Short Physical Performance Battery score (mean 4.8 points, 95% confidence interval (CI) 4.2, 5.5) from post-surgery to 1-year follow-up and a clinically important decline in EuroQol-5-dimension-5-level (mean -0.12 points, CI -0.16, -0.07) from baseline to 1-year follow-up. The decline in Barthel-index from baseline to 1-year follow-up was greater in the regular rehabilitation group (mean –2.3 points, CI -4.2, -0.2) than in the home group (mean -0.6 points, CI -1.4, 0.2) and specialised rehabilitation group (mean -0.4 points, CI -2.4, 1.6). Participants in the regular rehabilitation group were more frequently readmitted (standardised Pearson residual 4.1) and mortality rates were higher in the nursing home group (standardised Pearson residual 7.8) during the first year.

Conclusions
Orthogeriatric treatment pathways for hip fracture patients entailed differentiation based on factors such as age, mobility, comorbidity and physical function. Participants in all pathways improved in physical performance-scores, yet experienced decline in quality of life-scores during follow-up. Overall readmission and mortality rates were not influenced, but varied between pathways. Further research is needed to investigate the need for differentiated hospital treatment and its potential effects on rehabilitation after discharge.
Hyperacute reactivation of cytomegalovirus-induced gastroduodenitis during remission induction in a young male patient with granulomatosis with polyangiitis: a case report and review of literature
Authors: George Nisha Annie , Surendran Sandeep , Paulose Roopa Rachel , Pradeep Manu 
Published: February 2025

Abstract

Background
Cytomegalovirus is a pathogen known to aggravate the inflammatory response in autoimmune diseases via molecular mimicry. Although it is recognized that cytomegalovirus activation can happen during extended but variable periods of immunosuppression (14–90 days), it is rarely reported in conjunction with an acute flare-up of an autoimmune disease. Currently, there is no consensus on cytomegalovirus prophylaxis for patients initiating remission induction.

Case presentation
Here, we present the case of a 31-year-old male patient of South Indian ethnicity, presenting with a 2-month history of fever, conductive hearing loss, and ear discharge. This was associated with symmetrical inflammatory polyarthritis for 1 month, unilateral painful conjunctivitis, and skin erythema for 5 days. Blood analyses showed elevated inflammatory markers; strongly positive anti-proteinase 3 and cytoplasmic antineutrophil cytoplasmic antibody levels; normal procalcitonin and complement levels; and negative anti-myeloperoxidase and perinuclear antineutrophil cytoplasmic antibody levels. A nasal endoscopy revealed a midline granuloma with vasculitis features on biopsy. Imaging revealed pulmonary nodules and otomastoiditis. Now diagnosed with granulomatosis with polyangiitis, the patient developed signs of gastroduodenitis within a day of initiation of immunosuppression with high-dose “pulse” intravenous methylprednisolone. We evaluated him for mesenteric ischemia/gastrointestinal vasculitis. However, the duodenal biopsies from the bleeding ulcers revealed a probable cytomegalovirus infection, confirmed with high serum viral loads. We treated him with a ganciclovir regimen and transitioned him to steroid-sparing immunosuppressant therapy with mycophenolate mofetil, which was selected over cyclophosphamide for its noninferior effectiveness and better safety profile in non-life-threatening granulomatosis with polyangiitis disease. The patient recovered uneventfully and is currently in remission.

Conclusion
Cytomegalovirus reactivation is possible during short-term steroid pulse therapy. Further research is needed to evaluate whether routine cytomegalovirus screening is warranted before starting immunosuppressive treatment with high-dose steroids in autoimmune conditions.
English language education in Chinese primary schools: exploring EFL teachers’ attitudes, self-efficacy, and perceived school environment
Authors: Song Jie , Mullick Jahirul , Jiang Tao 
Published: February 2025

Abstract
This study aims to examine the attitudes, self-efficacy and perceived school environment of English as a Foreign Language (EFL) teachers in primary schools in China. Additionally, it seeks to explore the potential correlations between these aspects and demographic and contextual factors. A questionnaire comprising four scales was administered to a randomly chosen sample of EFL teachers (n = 861) from Zhejiang province in China. Data analysis was conducted using SPSS 26.0, employing descriptive statistics and inferential statistics, including ANOVA and linear regression. The findings reveal significant disparities in attitudes on professional identity, self-efficacy, and perceptions of the school environment among teachers in different school settings. The order of variables followed a descending pattern (i.e., urban teachers > suburban teachers > rural teachers). EFL teachers in primary schools, particularly those in rural areas, displayed lower professional identity, reduced confidence in effectively engaging students, and greater reliance on students’ responsibility in their own learning. It holds implications for stakeholders committed to enhancing the quality of English instruction for young learners.
Comparative analysis of machine learning and statistical models for cotton yield prediction in major growing districts of Karnataka, India
Authors: Thimmegowda M. N. , Manjunatha M. H. , Lingaraj H. , Soumya D. V. , Jayaramaiah R. , Sathisha G. S. , Nagesha L. 
Published: February 2025

Abstract

Background
Cotton is one of the most important commercial crops after food crops, especially in countries like India, where it’s grown extensively under rainfed conditions. Because of its usage in multiple industries, such as textile, medicine, and automobile industries, it has greater commercial importance. The crop’s performance is greatly influenced by prevailing weather dynamics. As climate changes, assessing how weather changes affect crop performance is essential. Among various techniques that are available, crop models are the most effective and widely used tools for predicting yields.

Results
This study compares statistical and machine learning models to assess their ability to predict cotton yield across major producing districts of Karnataka, India, utilizing a long-term dataset spanning from 1990 to 2023 that includes yield and weather factors. The artificial neural networks (ANNs) performed superiorly with acceptable yield deviations ranging within ± 10% during both vegetative stage (F1) and mid stage (F2) for cotton. The model evaluation metrics such as root mean square error (RMSE), normalized root mean square error (nRMSE), and modelling efficiency (EF) were also within the acceptance limits in most districts. Furthermore, the tested ANN model was used to assess the importance of the dominant weather factors influencing crop yield in each district. Specifically, the use of morning relative humidity as an individual parameter and its interaction with maximum and minimum temperature had a major influence on cotton yield in most of the yield predicted districts. These differences highlighted the differential interactions of weather factors in each district for cotton yield formation, highlighting individual response of each weather factor under different soils and management conditions over the major cotton growing districts of Karnataka.

Conclusions
Compared with statistical models, machine learning models such as ANNs proved higher efficiency in forecasting the cotton yield due to their ability to consider the interactive effects of weather factors on yield formation at different growth stages. This highlights the best suitability of ANNs for yield forecasting in rainfed conditions and for the study on relative impacts of weather factors on yield. Thus, the study aims to provide valuable insights to support stakeholders in planning effective crop management strategies and formulating relevant policies.
Identification of key biomarkers in breast cancer based on bioinformatics analysis and experimental verification
Authors: Huan Yu , She Ping , Cai Xushan , Qi Jiehua , Zhang Chunli 
Published: February 2025

Abstract

Background
Breast cancer (BC) is a malignant tumor characterized by a high incidence rate and is the leading cause of cancer-related deaths among women worldwide. This study aims to identify key genes and potential prognostic biomarkers using a bioinformatics approach.

Methods
Three microarray datasets, GSE86374, GSE120129, and GSE29044, were downloaded from the GEO database. GEO2R and Venn diagram software were employed to identify differentially expressed genes (DEGs), while DAVID was utilized for functional enrichment analysis. Subsequently, STRING and Cytoscape were used to construct the protein–protein interaction (PPI) network among the DEGs. UALCAN, GEPIA, and the Kaplan–Meier plotter were employed for prognostic analysis. Following this, the correlations and alterations of key genes were examined using cBioPortal. Finally, immunohistochemistry (IHC) was performed to validate the expression levels of the key genes.

Results
A total of 323 differentially expressed genes (DEGs) were identified. From the protein–protein interaction (PPI) network, 37 hub genes were selected. Validation using UALCAN, GEPIA, and Kaplan–Meier plotters revealed that three key genes—RACGAP1, SPAG5, and KIF20A—were significantly overexpressed and associated with poor prognosis in breast cancer (BC), as well as advanced tumor staging. The correlations and alterations of these key genes, as demonstrated on cBioPortal, indicated that their alterations co-occurred. Experimental verification through immunohistochemistry (IHC) confirmed that the proteins of these key genes were highly expressed in tumor tissues.

Conclusions
The key genes identified in this study can enhance our understanding of the molecular mechanisms underlying breast cancer (BC). Additionally, these genes may serve as potential sensitive biomarkers for patients with BC.
The mediating role of brand image in the relationship between storytelling marketing and purchase intention: case study of PX mart
Authors: Chang Joshua 
Published: February 2025

Abstract
This paper examines an understudied aspect of narrative-based marketing by analyzing the mediating role of brand image in the relationship between storytelling marketing and purchase intention, using PX Mart as a case study. Although prior research highlights the significance of storytelling in fostering consumer engagement, relatively few investigations have systematically addressed how the specific dimensions of storytelling—credibility, resonance, and extensibility—shape brand image and, subsequently, purchase intention. This study fills that gap by offering a novel perspective on how narrative-based strategies can enhance brand value and drive consumer behavior. A quantitative research design was adopted, involving the administration of a structured questionnaire to PX Mart customers. A quantitative research design was adopted, involving the administration of a structured questionnaire to PX Mart customers. To validate the current relevance of the findings, a supplementary qualitative survey was also conducted. Three dimensions of storytelling marketing were evaluated to determine their respective impacts on brand image and purchase intention. Guided by Baron and Kenny’s (1986) mediation model, multiple regression and mediation analyses were performed to explore how storytelling indirectly influences purchase intention through brand image. Results indicate that storytelling marketing significantly increases purchase intention, with brand image serving as a partial mediator. Among the three dimensions, credibility exerts the most pronounced direct effect on both brand image and purchase intention, while resonance and extensibility also yield positive, though comparatively smaller, effects. These findings underscore the importance of brand image as a mediator that links storytelling marketing to consumer purchase behavior, thereby making a novel theoretical contribution to branding research. From a practical standpoint, these insights provide marketers with concrete strategies for enhancing brand loyalty and consumer purchasing through storytelling. By focusing on credibility, resonance, and extensibility in their brand narratives, businesses can more effectively reinforce brand image and influence buying decisions—an approach particularly relevant for retail and consumer goods sectors seeking to forge deeper emotional connections with their audiences.
Adult Growth Hormone Deficiency (AGHD) and Outcomes (NordiNet and ANSWER)
Authors: Carmichael John D , Kargi Atil Y , Dichtel Laura , Kelepouris Nicky , Nedjatian Navid , Fridman Moshe , Weber Matthias M 
Published: February 2025

Abstract
Adult growth hormone deficiency (AGHD) is a rare disease with both physiological and psychological effects for untreated patients. AGHD symptoms can improve over time with growth hormone (GH) treatment. Here, we have analyzed the long-term effectiveness and safety of short-acting growth hormone replacement therapy (GHRT) in treatment naïve and non-naïve patients with AGHD using real-world data from the NordiNet® International Outcome Study and American Norditropin® Studies: Web Enabled Research Program. Outcomes were compared between 3 age groups, comprised of patients aged 18 to 29 years, 30 to 39 years, and 40 to 59 years. The safety outcome was the incidence of nonserious and serious adverse reactions and serious adverse events by age group. Efficacy outcomes included mean GH exposure by age group alone, by sex and age group, or based on estrogen usage in female patients; IGF-I SDS levels by sex and age group; Mean HbA1c by sex and age group; and mean non-HDL cholesterol by sex and age group. The incidence rates of adverse events and reactions did not statistically differ between the 3 groups. Mean insulin-like growth factor 1 (IGF-I) standard deviation score (SDS) levels reached a normal range (-2 to 2) in ≥80% of patients from all groups in the effectiveness analysis set by year 2. Together with previous reports of older patients, these results support the real-world safety and efficacy of short-acting GHRT among all ages of patients with AGHD.
Προσδιορισμός των κυριότερων ηθικών και ηγετικών χαρακτηριστικών ενός εκπαιδευτικού στελέχους
Authors: Σπυριδάκης Αντώνιος , Αργυροπούλου Ελευθερία , Λιντζεράκου Ελισσάβετ 
Published: February 2025

Σκοπός της παρούσας έρευνας ήταν ο ακριβής προσδιορισμός της έννοιας του «καλού» εκπαιδευτικού στελέχους μέσω της ανίχνευσης των σημαντικότερων ηθικών και ηγετικών χαρακτηριστικών του. Στην κατεύθυνση αυτή, κρίθηκε απαραίτητη η συμμετοχή αποκλειστικά εν ενεργεία εκπαιδευτικών στελεχών (Διευθυντών σχολικών μονάδων). Ο προσδιορισμός των κυριότερων ηθικών και ηγετικών χαρακτηριστικών ενός εκπαιδευτικού στελέχους επιτεύχθηκε ως εξής:
Μέσω βιβλιογραφικής έρευνας εντοπίστηκαν τα δέκα (10) κυριότερα ηθικά και τα έντεκα (11) κυριότερα ηγετικά χαρακτηριστικά ενός ηγέτη. Στη συνέχεια, αρχικά σε πιλοτική έρευνα είκοσι πέντε (25) Διευθυντών και Διευθυντριών σχολικών μονάδων πρωτοβάθμιας και δευτεροβάθμιας εκπαίδευσης, και στη συνέχεια στην κυρίως έρευνα, με εκατό (100) συμμετέχοντες από όλες τις περιφέρειες της χώρας, ζητήθηκε ο προσδιορισμός των πέντε (5) σημαντικότερων χαρακτηριστικών από κάθε κατηγορία και η κατάταξη σπουδαιότητάς τους. Η δικαιοσύνη, η ακεραιότητα και η ψυχραιμία (πραότητα) τοποθετήθηκαν από τα ερωτώμενα στελέχη στην κορυφή των κυριότερων ηθικών αρετών ενός εκπαιδευτικού στελέχους, ενώ οι οργανωτικές δεξιότητες, η ικανότητα έμπνευσης των υφισταμένων και η ενσυναίσθηση επιλέχθηκαν ως τα σημαντικότερα ηγετικά χαρακτηριστικά του.
Exchanges for Government Bonds? Evidence During COVID-19
Authors: Kutai Ari , Nathan Daniel , Wittwer Milena 
Published: February 2025

We leverage the unique institutional feature that the Israeli government bond market operates on an exchange rather than over-the-counter to analyze whether and why having an exchange affects market liquidity during a crisis. We document how the liquidity crisis in March 2020 affected the Israeli government bond market and conduct difference-in-differences analyses, comparing bid-ask spreads in exchange markets, such as the Israeli government bond market, with markets lacking an exchange. Our findings support the idea that having an exchange enhances market liquidity. A counterfactual analysis using trade data from the Israeli exchange suggests that this is due to the ability of investors to readily provide liquidity to one another and the efficient netting of trade flows on an exchange. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2023.02344 .
Enhancing communication in healthcare: Supports for interactions between adults with hearing loss and healthcare providers
Authors: Garcia Ana Carla , Arabi Ali , Croteau Claire , de Lacerda Adriana Bender Moreira 
Published: February 2025

Background
Communication between a healthcare provider and an adult with hearing loss can be challenging and potentially contribute to health outcomes. To overcome this challenge, researchers have called for urgent multidisciplinary action on communication support in hearing healthcare.

Objective
This scoping review examines the existing literature on communication support that can be provided to adults with hearing loss during their interactions with healthcare professionals.

Methods
An online search was conducted using EMBASE, MEDLINE, CINAHL, and PsycINFO. All studies were imported into the Covidence platform for screening. The studies included in this analysis were published in English between 2013 and 2024.

Results
Twelve articles were included in this review, and seven themes were identified: supportive nonverbal strategies, supportive verbal strategies, human support, environmental and physical adaptations, technological support, education and training, and psychological support and counseling.

Conclusions
When communicating with a healthcare provider, adults with hearing loss can be assisted through supportive communication strategies.
Estimating the dietary and health impact of implementing mandatory front-of-package nutrient disclosures in the US: A policy scenario modeling analysis
Authors: Flexner Nadia , Zaltz Daniel , Greenthal Eva , Musicus Aviva A. , Ahmed Mavra , L’Abbe Mary R. 
Published: February 2025

Background
Recognized as a cost-effective policy to promote healthier diets, mandatory front-of-package labeling (FOPL) identifying foods high in sodium, sugar, and saturated fat has been adopted and implemented in ten countries, and is currently under consideration in several others including the US. However, its potential impact on dietary intake and health have not yet been estimated in the US context.

Objectives
To estimate (1) the potential dietary impact of implementing mandatory nutrient-specific ‘high in’ FOPL among US adults; and (2) the number of diet related non-communicable disease (NCD) deaths that could be averted or delayed due to estimated dietary changes.

Methods
Baseline and counterfactual dietary intakes of sodium, sugars, saturated fats, and calories were estimated among US adults (n = 7,572) using both available days of 24h recall data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). The National Cancer Institute method was used to estimate usual intakes and distributions, adjusting for age, sex, misreporting status, weekend/weekday, and sequence of recall. To estimate counterfactual dietary intakes, we modeled two reduction scenarios observed in experimental and observational studies that examined changes in sodium, sugars, saturated fat and calorie content of food and beverage purchases due to nutrient-specific ‘high in’ FOPL. This study used the Preventable Risk Integrated ModEl (PRIME) to estimate potential health impacts.

Results
Estimated mean dietary reductions of 156 mg and 259 mg/day of sodium, 10.1 g and 7.2 g/day of sugars, 1.08 g and 4.49 g/day of saturated fats, and 38 kcal and 57 kcal/day of calories were observed under the two policy scenarios tested. Between 96,926 (95% UI 89,011–105,284) and 137,261 (95% UI 125,534–148,719) diet related NCD deaths, primarily from cardiovascular diseases (74%), could potentially be averted or delayed by implementing mandatory nutrient-specific FOPL in the US. Overall, more lives would be saved in males than females.

Conclusions
Findings suggest that implementing mandatory nutrient-specific ‘high in’ FOPL in the US could significantly reduce sodium and total sugar intakes among US adults, resulting in a substantial number of NCD related deaths that could be averted or delayed. Our results can inform current food policy developments in the US regarding the adoption and implementation of FOPL regulations.