bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public-Private Drift and the Shattering Polity
Authors: DeGirolami Marc O 
Published: June 2023

Abstract
This paper approaches the public-private law problem by describing what it calls “drift.” Drift is the tendency of what is thought traditionally to be private law to become public (public drift), and the tendency of what is thought traditionally to be public law to become private (private drift). Though it is possible to distinguish public and private drift conceptually, drift is in practice a unified phenomenon: public and private drift go together. Drift is manifested not only in formal, legal developments, but also in the informal processes by which public law frameworks now influence private ordering, private rulemaking, and private relationships, as well as the way private authorities have been entrusted with the responsibility to implement those public law frameworks.
The paper describes various contemporary examples of drift, explains drift’s comparative ascendancy today, and speculates about possible future developments for drift. Drift in public and private law may not be driven primarily by anything innate or conceptually necessary in the disciplines believed to constitute private or public law. Drift is instead a political byproduct, the issue of social and cultural anxieties concerning the absence of anything like a common political project, anxieties that drive powerful actors toward manufacturing imaginary commonalities that they press with confounding certitude. The powerful exploit and manipulate areas of law that properly pertain to the public and private domains, repurposing them for new uses, because their regular use is ineffective in achieving their political objectives. The paper deliberately selects examples of drift that exhibit what would be conventionally described as conservative and progressive valences (in the meteoric rise of public nuisance, in the strategy of statutes like Texas’ S.B. 8, in the mixed public-private response to COVID-19, in the controversies about social media speech control, and others) to illustrate the universality of the phenomenon. Drift is a response to a perceived political void or emptiness in which public-private partnerships of powerful actors emerge to fill the void, capture the institutions of power, and coerce people’s behavior into certain ideological grooves.
Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study
Authors: Li Dingfeng , Zhang Catherine D , Saini Jasmine , Singh Sumitabh , Nathani Rohit , Thangamuthu Karthik , Suresh Malavika , Atkinson Elizabeth J , Achenbach Sara J , Van Gompel Jamie , Young William F , Bancos Irina 
Published: June 2023

Abstract

Objective
Prospective data on determinants of muscle strength impairment and quality of life in patients with various subtypes and severity of endogenous hypercortisolism are lacking.

Design
Single-center cross-sectional study, 2019 to 2022.

Methods
Patients with Cushing syndrome (CS) and mild autonomous cortisol secretion (MACS) were assessed with clinical and biochemical severity scores, muscle function (nondominant hand grip strength and sit-to-stand test), and quality of life (Short Form-36 [SF36] and CushingQoL). Referent subjects were recruited from the local population undergoing abdominal imaging for reasons other than suspected adrenal disorder.

Results
Of 164 patients, 81 (49%) had MACS, 14 (9%) had adrenal CS, 60 (37%) had pituitary CS, and 9 (5%) had ectopic CS. Median age was 53 years (interquartile range: 42-63 years), and 126 (77%) were women. The SF36 mental component score was similarly low in patients with MACS vs CS, but physical component score was lower in CS when compared to MACS (mean of 34.0 vs 40.5, P = .001). Compared to MACS, patients with CS had lower scores on the standardized CushingQoL (mean of 47.1 vs 34.2, P &lt; .001). Compared to referent subjects, patients with MACS demonstrated reduced muscle strength, similar to patients with CS (mean sit to stand Z-score of −0.47 vs −0.54, P = .822). Clinical severity (r = −0.22, P = .004) but not biochemical severity was associated with sit-to-stand test performance.

Conclusions
Both patients with overt CS and MACS demonstrate reduced muscle strength and low quality of life. The clinical severity score utilized is associated with both physical and psychosocial components of CushingQoL and with the physical component of SF36.
Waves of inequality: income differences in intensive care due to Covid-19 in Sweden
Authors: Gauffin Karl , Östergren Olof , Cederström Agneta 
Published: June 2023

Abstract

Background
Socioeconomically vulnerable groups were overall more likely to develop severe Covid-19, but specific conditions in terms of preparedness, knowledge and the properties of the virus itself changed during the course of the pandemic. Inequalities in Covid-19 may therefore shift over time. This study examines the relationship between income and intensive care (ICU) episodes due to Covid-19 in Sweden during three distinct waves.

Methods
This study uses Swedish register data on the total adult population and estimates the relative risk (RR) of ICU episodes due to Covid-19 by income quartile for each month between March 2020 and May 2022, and for each wave, using Poisson regression analyses.

Results
The first wave had modest income-related inequalities, while the second wave had a clear income gradient, with the lowest income quartile having an increased risk compared to the high-income group [RR: 1.55 (1.36–1.77)]. In the third wave, the overall need for ICU decreased, but RRs increased, particularly in the lowest income quartile [RR: 3.72 (3.50–3.96)]. Inequalities in the third wave were partly explained by differential vaccination coverage by income quartile, although substantial inequalities remained after adjustment for vaccination status [RR: 2.39 (2.20–2.59)].

Conclusions
The study highlights the importance of considering the changing mechanisms that connect income and health during a novel pandemic. The finding that health inequalities increased as the aetiology of Covid-19 became better understood could be interpreted through the lens of adapted fundamental cause theory.
Growth Hormone Secretagogues as Potential Therapeutic Agents to Restore Growth Hormone Secretion in Older Subjects to Those Observed in Young Adults
Authors: Smith Roy G , Thorner Michael O 
Published: June 2023

Abstract
The discovery of the growth hormone secretagogues (GHS) and the reverse pharmacology leading to the discovery of GHS receptor which enabled the identification of ghrelin as the natural ligand for the receptor have opened a new horizon in growth hormone (GH) physiology, pathophysiology, and therapeutics. Major progress has been made and we now have orally active GHS which are able to restore optimal pulsatile GH secretion which cannot be overstimulated as insulin-like growth factor feedback regulates the peaks to the optimum level. This enables GH to be restored in the older to levels normally seen in 20- to 30-year-old people; this leads to an increase in fat-free mass and redistribution of fat to the limbs. As these agents are ultimately approved and investigated further, it is likely that they will be shown to restore growth in children with moderate-to-mild GH deficiency; their benefits will be investigated in other indications such as nonalcoholic fatty liver disease, frailty, anemia, osteoporosis, and immune compromise in older subjects. The exquisite regulation of GH secretion reflects the importance of GH pulsatility in the regulation of somatotroph action of GH.
Exercise and Behavior: Adjuncts to Pro-Myogenic Compounds for Enhancing Mobility in Older Adults
Authors: Storer Thomas W , Pahor Marco , Woodhouse Linda J , Lachman Margie E , Fielding Roger A 
Published: June 2023

Abstract
Physical activity and exercise training exert multiple and varied beneficial effects on a wide array of human tissues, making them therapeutic modalities that can prevent and treat age-related decline in physical function. The Molecular Transducers of Physical Activity Consortium is currently working to elucidate the molecular mechanisms underlying how physical activity improves and preserves health. Exercise training, especially when task specific, is an effective intervention for improving skeletal muscle performance and physical function in everyday activities. As seen elsewhere in this supplement, its adjunctive use with pro-myogenic pharmaceuticals may prove to be synergistic in effect. Behavioral strategies aiming to promote exercise participation and sustain adherence are being considered as additional adjuncts to further improve physical function in comprehensive, multicomponent interventions. One application of this combined strategy may be to target multimodal pro-myogenic therapies in prehabilitation to optimize physical preoperative health to enhance functional recovery postsurgery. We summarize here recent progress on biological mechanisms of exercise training, behavioral approaches to exercise participation, and the role task-specific exercise plays in synergy with pharmacologic therapies with a particular focus on older adults. Physical activity and exercise training in multiple settings should serve as the baseline standard of care around which other therapeutic interventions should be considered when the goal is restoring or increasing physical function.
Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating
Authors: Panda Satchidananda , Maier Geraldine , Villareal Dennis T 
Published: June 2023

Abstract
With the rise in obesity across age groups, it has been a hindrance to engaging in physical activity and mobility in older adults. Daily calorie restriction (CR) up to 25% has been the cornerstone of obesity management even though the safety in older adults remains incompletely understood. Although some adults can follow CR with clinically significant weight loss and improved health metrics, CR faces 2 obstacles—many fail to adopt CR and even among those who can adopt it short term, long-term compliance can be difficult. Furthermore, there is a continuing debate about the net benefits of CR-induced weight loss in older adults because of the concern that CR may worsen sarcopenia, osteopenia, and frailty. The science of circadian rhythm and its plasticity toward the timing of nutrition offer promise to alleviate some challenges of CR. The new concept of Time-Restricted Feeding/Eating (TRF for animal studies and TRE for human studies) can be an actionable approach to sustaining the circadian regulation of physiology, metabolism, and behavior. TRE can often (not always) lead to CR. Hence, the combined effect of TRE through circadian optimization and CR can potentially reduce weight and improve cardiometabolic and functional health while lessening the detrimental effects of CR. However, the science and efficacy of TRE as a sustainable lifestyle in humans are in its infancy, whereas animal studies have offered many desirable outcomes and underlying mechanisms. In this article, we will discuss the scope and opportunities to combine CR, exercise, and TRE to improve functional capacity among older adults with obesity.
EraSOR: a software tool to eliminate inflation caused by sample overlap in polygenic score analyses
Authors: Choi Shing Wan , Mak Timothy Shin Heng , Hoggart Clive J , O'Reilly Paul F 
Published: June 2023

Abstract

Background
Polygenic risk score (PRS) analyses are now routinely applied across biomedical research. However, as PRS studies grow in size, there is an increased risk of sample overlap between the genome-wide association study (GWAS) from which the PRS is derived and the “target sample,” in which PRSs are computed and hypotheses are tested. Despite the wide recognition of the sample overlap problem, its potential impact on the results from PRS studies has not yet been quantified, and no analytical solution has been provided.

Findings
Here, we first conduct a comprehensive investigation into the scale of the sample overlap problem, finding that PRS results can be substantially inflated even in the presence of minimal overlap. Next, we introduce a method and software, EraSOR (Erase Sample Overlap and Relatedness), which eliminates the inflation caused by sample overlap (and close relatedness) in almost all settings tested here.

Conclusions
EraSOR could be useful in PRS studies (with target sample &gt;1,000) similar to those investigated here, either (i) to mitigate the potential effects of known or unknown intercohort overlap and close relatedness or (ii) as a sensitivity tool to highlight the possible presence of sample overlap before its direct removal, when possible, or else to provide a lower bound on PRS analysis results after accounting for potential sample overlap.
Migrant gardeners, health and wellbeing: exploring complexity and ambivalence from a UK perspective
Authors: Gerodetti Natalia , Foster Sally 
Published: June 2023

Abstract
There has been increasing interest in how green spaces and gardening contribute to people’s physical, mental and social wellbeing, and this interest has increased due to COVID-19. This article explores the particular experiences of migrant gardeners and the implications for their health and wellbeing. It draws on a qualitative research project that involved conducting semi-structured interviews with participants with migration heritage in and around a city in the north of England. The participants were recruited through purposive and snowball sampling; of the 25 participants, some were allotment holders, whilst the rest cultivated crops in their gardens or even on their balcony. Thematic analysis of the interview transcripts generated themes that reflect current definitions of health, encompassing physical, mental and social wellbeing. However, whilst the findings confirm many positive effects of gardening, they also point to some ambivalence in relation to cultivation, outdoor practices and health, with evidence of neutral or even negative effects at times. The article explores the implications of these findings for initiatives to encourage gardening, such as social prescribing, and to address ‘green poverty’. An additional finding is that for gardeners with migration heritage, gardening can be understood in terms of cultural wellbeing. Consequently, there is a need to broaden the concept of wellbeing to include this cultural dimension.
A Generalization of Newton–Maclaurin’s Inequalities
Authors: Ren Changyu 
Published: June 2023

Abstract
In this paper, we prove Newton–Maclaurin-type inequalities for functions obtained by linear combination of two neighboring primary symmetry functions, which is a generalization of the classical Newton–Maclaurin inequality. Using these inequalities, we also generalize some inequalities of Lin and Trudinger [18], which are relevant to the study of partial differential equations associated with curvature problems.
Biosensor development for single-cell detection of glucuronate
Authors: Nash Jennifer Kaczmarek , Prather Kristala L J 
Published: June 2023

Abstract

Recent work in biosensors has shown promise to enable high throughput searches through large genetic libraries. However, just as physiological limitations and lack of in-depth mechanistic knowledge can prevent us from achieving high titers in microbial systems; similar roadblocks can appear in the application of biosensors. Here, we characterized a previously developed transcription-factor (ExuR) based galacturonate biosensor for its other cognate ligand, glucuronate. Though we saw an ideal response to glucuronate from the biosensor in controlled and ideal experimental circumstances, these results began to deviate from a well-behaved system when we explored the application of the sensor to different MIOX homologs. Through modifications to circuit architecture and culture conditions, we were able to decrease this variation and use these more optimal conditions to apply the biosensor for the separation of two closely related MIOX homologs.

One-Sentence Summary
In this work, a transcription-factor biosensor was investigated for its potential to screen a library of myo -inositol oxygenase variants while seeking to mitigate the impact the production pathway appeared to have on the biosensor.
Does Work Quality Differ between the Public and Private Sectors? Evidence from Two Online Field Experiments
Authors: Andersen Simon Calmar , Bruntse Morten , James Oliver , Jilke Sebastian 
Published: June 2023

Abstract
Understanding the differences between working in the public and private sectors is core to public management research. We assess the implications of a theory of public ownership, testing an expectation that work is of higher quality when performed under public ownership status compared to a private company. We conducted two, pre-registered, field experiments with a routine data processing task and workers recruited through an online labor market. Workers were randomly allocated information about the ownership status of a nursing home as either a public organization or a private company. Work quality was measured as errors workers made in data entry and correcting pre-existing errors in work materials provided to them. The first experiment showed that fewer workers in the public, compared to the private, nursing home tended to make any data entry errors but that they did not correct more existing errors. Exploratory analyses showed a greater effect for those aware of the organization’s ownership status. To test this apparent sector attention effect, we conducted a second experiment with a 2-by-2 factorial design randomly allocating workers to a treatment making salient the public or private sector status of the organization, in addition to the initial public or private sector treatment. The results confirmed the effect of public sector status and sector attention in combination; workers who were assigned to a public sector organization rather than a private company and who were made aware of the respective sector status were more likely to perform their work tasks without any errors. We discuss the limits of the findings and their implications including that public organizations could boost the quality of work done by making their sector status more explicit to workers.
Cain Furens: Imitations Of Virgil and Ovid in Canto Six of Lucy Hutchinson’s Order And Disorder
Authors: Hillier Russell M 
Published: June 2023

Abstract
The article examines Lucy Hutchinson’s treatment of Cain and Abel in Canto Six of her biblical epic Order and Disorder. Hutchinson mobilises the classical tradition to elucidate the psychodrama of the fratricide Cain. Her imitation of four similes from Virgil’s Aeneid and Georgics, and the allegorical figure of Envy from Ovid’s Metamorphoses, helps to convey the dramatic shifts in Cain’s psychological and spiritual state. Moreover, Hutchinson’s evocation of the reprobate Cain’s restlessness through intertextual engagement with Virgil supports the Calvinist doctrine of double predestination. In Order and Disorder, Virgil and Ovid’s Roman poems are aids to embellishing and enhancing the narrative and theology of Hutchinson’s biblical epic.
Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites
Authors: Dexter Eric , Fields Peter D , Ebert Dieter 
Published: June 2023

Abstract
Understanding the genomic basis of infectious disease is a fundamental objective in co-evolutionary theory with relevance to healthcare, agriculture, and epidemiology. Models of host-parasite co-evolution often assume that infection requires specific combinations of host and parasite genotypes. Co-evolving host and parasite loci are, therefore, expected to show associations that reflect an underlying infection/resistance allele matrix, yet little evidence for such genome-to-genome interactions has been observed among natural populations. We conducted a study to search for this genomic signature across 258 linked host (Daphnia magna) and parasite (Pasteuria ramosa) genomes. Our results show a clear signal of genomic association between multiple epistatically interacting loci in the host genome, and a family of genes encoding for collagen-like protein in the parasite genome. These findings are supported by laboratory-based infection trials, which show strong correspondence between phenotype and genotype at the identified loci. Our study provides clear genomic evidence of antagonistic co-evolution among wild populations.
Examining the inorganic elemental composition of lobster phyllosoma (Panulirus ornatus) with X-ray fluorescence microscopy
Authors: McDougall Daniel R , Deas Robert , Howard Daryl L , Fitzgibbon Quinn P , Smith Gregory G , Jeffs Andrew G , McGillivray Duncan J 
Published: June 2023

Abstract
The ornate spiny rock lobster, Panulirus ornatus, is an attractive candidate for aquaculture. The larval stages of spiny lobsters, known as phyllosoma, are complex with many developmental stages. Very little is known about the inorganic element composition of phyllosoma. In this study, a novel method using synchrotron X-ray fluorescence microscopy (XFM) was applied to investigate the distributions of metals potassium (K), calcium (Ca), copper (Cu), zinc (Zn), the metalloid arsenic (As), and nonmetal bromine (Br) within individual phyllosoma at stages 3, 4, and 8 of their development. For the first time, 1 µm resolution synchrotron XFM images of whole phyllosoma as well as closer examinations of their eyes, mouths, setae, and tails were obtained. Elements accumulated in certain locations within phyllosoma, providing insight into their likely biological role for these organisms. This information may be useful for the application of dietary supplementation in the future to closed larval cycle lobster aquaculture operations.
Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
Authors: Steen Nils Eiel , Rahman Zillur , Szabo Attila , Hindley Guy F L , Parker Nadine , Cheng Weiqiu , Lin Aihua , O’Connell Kevin S , Sheikh Mashhood A , Shadrin Alexey , Bahrami Shahram , Karthikeyan Sandeep , Hoseth Eva Z , Dale Anders M , Aukrust Pål , Smeland Olav B , Ueland Thor , Frei Oleksandr , Djurovic Srdjan , Andreassen Ole A 
Published: June 2023

Abstract

Background
Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting edge statistical tools to identify shared genetic variants between SCZ and white blood cell (WBC) counts and further understand the role of the immune system in SCZ.

Study Design
GWAS results from SCZ (patients, n = 53 386; controls, n = 77 258) and WBC counts (n = 56 3085) were analyzed. We applied linkage disequilibrium score regression, the conditional false discovery rate method and the bivariate causal mixture model for analyses of genetic associations and overlap, and 2 sample Mendelian randomization to estimate causal effects.

Study Results
The polygenicity for SCZ was 7.5 times higher than for WBC count and constituted 32%–59% of WBC count genetic loci. While there was a significant but weak positive genetic correlation between SCZ and lymphocytes (rg = 0.05), the conditional false discovery rate method identified 383 shared genetic loci (53% concordant effect directions), with shared variants encompassing all investigated WBC subtypes: lymphocytes, n = 215 (56% concordant); neutrophils, n = 158 (49% concordant); monocytes, n = 146 (47% concordant); eosinophils, n = 135 (56% concordant); and basophils, n = 64 (53% concordant). A few causal effects were suggested, but consensus was lacking across different Mendelian randomization methods. Functional analyses indicated cellular functioning and regulation of translation as overlapping mechanisms.

Conclusions
Our results suggest that genetic factors involved in WBC counts are associated with the risk of SCZ, indicating a role of immune mechanisms in subgroups of SCZ with potential for stratification of patients for immune targeted treatment.