bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐Time Auto Controlling of Viable Cell Density in Perfusion Cultivation Aided by In‐Line Dielectric Spectroscopy With Segmented Adaptive PLS Model
Authors: Sun Yunpeng , Zhang Qiongqiong , He Yunfei , Chen Dongliang , Wang Zheyu , Zheng Xiang , Fang Mingyue , Zhou Hang 
Published: January 2025

ABSTRACTServing as a dedicated process analytical technology (PAT) tool for biomass monitoring and control, the capacitance probe, or dielectric spectroscopy, is showing great potential in robust pharmaceutical manufacturing, especially with the growing interest in integrated continuous bioprocessing. Despite its potential, challenges still exist in terms of its accuracy and applicability, particularly when it is used to monitor cells during stationary and decline phases. In this study, data pre‐processing methods were first evaluated through cross‐validation, where the first‐order derivative emerged as the most effective method to diminish variability in prediction accuracy across different training datasets. Subsequently, a segmented adaptive partial least squares (SA‐PLS) model was developed, and its accuracy and universality were demonstrated through several validation studies using different clones and culture processes. Furthermore, a real‐time viable cell density (VCD) auto‐control system in perfusion culture was established, where the VCD was maintained around the target with notable precision and robustness. This model enhanced the monitoring capabilities of capacitance‐based PAT tools throughout the cultivation, expanded their application in cell‐specific automatic control strategies, and contributed vitally to the advancement of continuous manufacturing paradigms.
Impact of Centralisation of Radical Prostatectomy Driven by the Introduction of Robotic Systems on Positive Surgical Margin and Biochemical Recurrence in pT2 Prostate Cancer
Authors: Ibrahim Ibrahim , Kouli Omar , Ilangovan Sanjana , Sneddon Melanie , Nalagatla Sarika , Marshall Carol , Dutto Lorenzo , Leung Hing Y. , Ahmad Imran 
Published: January 2025

ABSTRACTBackgroundTo assess how centralisation of cancer services via robotic surgery influenced positive surgical margin (PSM) occurrence and its associated risk of biochemical recurrence (BCR) in cases of pT2 prostate cancer (PC).MethodsRetrospective analysis of all radical prostatectomy (RP) cases performed in the West of Scotland during the period from January 2013 to June 2022. Primary outcomes were PSM and BCR. The secondary outcomes compared the impact of centralisation and surgical approach on PSM and BCR; and margin length and location on BCR. Propensity score matching and Cox regression models were performed using R.ResultsA total of, 907 patients were included; 662 robot assisted radical prostatectomy (RARP), 245 open RP. PSM rate was 17.7% (161/907), similar in RARP and open cohorts. Patients with PSM had higher rates of BCR; 26.7%, compared to 8.7% in patients with no PSM. Patients with margins of ≥ 1 mm had higher risk of developing BCR. Patients who underwent open RP had increased incidence of PSM ≥ 1 mm; 40/43 (93%) compared to 83/117 (71%) in robotic approach (p = 0.003). Limitations include the study being retrospective, introduction of centralisation and robot concurrently, and evolution of practice.DiscussionPSMs in pT2 PC are associated with higher rates of BCR. Introduction of centralisation via the robot had no impact on PSM occurrence or BCR, although did demonstrate a reduction in PSM length.
Prognostic Factors and Nomogram for Malignant Brainstem Ependymoma: A Population‐Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis
Authors: Ji Xiaoyu , Yang Siyuan , Cheng Dejing , Zhao Wenbo , Sun Xuebo , Su Fang 
Published: January 2025

ABSTRACTPurposeThis study aimed to identify prognostic factors and develop a nomogram for survival in patients with brainstem ependymoma.MethodsData of 652 patients diagnosed with brainstem ependymoma extracted from the Surveillance, Epidemiology, and End Results (SEER) registry from 2000 to 2020 were analyzed. Univariate and multivariable Cox regression analyses were performed to examine factors influencing overall survival (OS). Receiver operating characteristic curve (ROC) and calibration curves were used to verify the nomogram. The Kaplan–Meier method was used to analyze OS based on treatment methods stratification or different age patterns.ResultsSix independent prognostic factors of patients with brainstem ependymoma were identified, including age, race, marital status, radiation, gross total resection (GTR), and histology. A comprehensive nomogram model was developed utilizing these predictors identified through multivariable Cox regression analysis. Furthermore, we found that patients with GTR have improved overall survival than patient with no surgery and biopsy only or with partial resection (GTR vs. no: p = 0.0004, GTR vs. partial resection: p = 0.022). Patients with radiation have improved overall survival than patient without radiation (p = 0.00013). Patients with GTR combined radiation therapy have improved overall survival than patient without or with GTR or radiation therapy only (p < 0.0001). Different treatment methods have no significant difference in the overall survival probability of the elderly group.ConclusionsIndividuals who are Black and anaplastic ependymomas were negative risk factors for brainstem ependymoma associated with an increased risk of mortality. Patients aged < 50 years with GTR and radiation always had better survival.
From Food Pantry to CARE Center in a Rural College: Our Journey
Authors: Shurtleff Carmen 
Published: January 2025

ABSTRACTResearch consistently describes the large percentage of community college students who struggle to meet their basic needs such as food and housing. These challenges may be exacerbated for students in rural communities. At the same time, we are also learning more about the connection between addressing students’ basic needs and improving their educational outcomes. Food pantries are a way community colleges have been responding to food insecurity, and recent trends include expansion of food pantries into basic needs hubs. This article walks through lessons learned in how a faculty member who teaches social work at Northeast Texas Community College, a small, rural college, developed their campus food pantry into a more holistic CARE Center, and did so in the middle of the COVID‐19 pandemic.
A comparative study benchmarking colon polyp with computer‐aided detection (CADe) software
Authors: Papachrysos Nikolaos , Smedsrud Pia Helén , Ånonsen Kim V. , Berstad Tor Jan D. , Espeland Håvard , Petlund Andreas , Hedenström Per J. , Halvorsen Pål , Varkey Jonas , Hammer Hugo L. , Riegler Michael A. , de Lange Thomas 
Published: January 2025

AbstractBackground and aimsComputer‐aided detection software (CADe) has shown promising results in real‐time polyp detection, but a limited head‐to‐head comparison of the available CADe systems has been performed. Moreover, such systems have not been compared to endoscopists using standardized videos. This study aims to compare the performance of three CADe systems in detecting polyps, employing a novel standardized methodology.MethodsVideos from 300 colonoscopies conducted at Oslo University Hospital were analyzed. Short video clips (20–45 s) presenting normal mucosa or polyps were randomly selected. These videos were then streamed through each CADe system from Medtronic, Olympus, and Augere Medical. Each system featured diverse configurations, resulting in a total of six software settings. Sensitivity and false positivity (FP) were assessed by comparing the CADe systems to both the mean of the systems and pairwise between them. Furthermore, the systems’ performance was compared to the performance of five endoscopists.ResultsCADe systems’ sensitivity ranged between 84.9% and 98.7%, with statistically significant differences observed between the systems, both in comparison to the mean and to each other. FP rates ranged between 1.2% and 5.6%, also differing statistically significantly between the systems. The CADe systems achieving the highest sensitivity also exhibited the highest FP. Statistically significant differences in the alert delay were observed between different CADe systems and endoscopists.ConclusionsThis study highlights significant differences between commercially available CADe software regarding sensitivity and FP, but a superior performance compared to endoscopists. The software with the highest sensitivity also exhibited the highest FP, highlighting the need for further refinement.
Early CRPS Is a Heterogeneous Condition: Results From a Latent Class Analysis
Authors: Louis Marc‐Henri , Legrain Valéry , Aron Vladimir , Filbrich Lieve , Henrard Séverine , Barbier Olivier , Libouton Xavier , Mouraux Dominique , Lambert Julien , Berquin Anne 
Published: January 2025

ABSTRACTBackgroundComplex regional pain syndrome (CRPS) is a debilitating condition characterised by significant heterogeneity. Early diagnosis is critical, but limited data exists on the condition's early stages. This study aimed to characterise (very) early CRPS patients and explore potential subgroups to enhance understanding of its mechanisms.MethodsA total of 113 early CRPS patients were recruited, with 89 undergoing physical assessments. Data included demographic information, work‐related factors, CRPS history and clinical features, body perception disturbances, quantitative sensory testing (QST), and a visuospatial attention task.ResultsQST identified deficits in detecting thermal and mechanical stimuli, alongside increased sensitivity to thermal and blunt pressure painful stimuli. Participants reported body perception disturbances similar to those of persistent CRPS. Visuospatial biases were observed in two subgroups of patients. Latent class analysis (LCA) of 85 participants, based on five clinical parameters, identified four profiles: Mild, Moderate, Body Representation Disturbance (BRD), and Pressure Allodynia CRPS. The Mild and Moderate profiles were associated with higher‐intensity trauma, with the latter showing worse outcomes. BRD and Pressure Allodynia CRPS followed mild trauma but exhibited the poorest outcomes. BRD CRPS displayed significant body perception disturbances, while Pressure Allodynia CRPS presented the highest sensitivity to pressure and psychosocial risk of chronification. Neither condition duration nor skin temperature effectively distinguished subgroups.ConclusionsThese findings emphasise the heterogeneity within (very) early CRPS patients and support the absence of a minimum required duration prior to the CRPS diagnosis. Central/systemic mechanisms may play critical roles in severe cases.SignificanceThis study identifies distinct (very) early CRPS profiles, suggesting different pathophysiological mechanisms and challenging traditional classifications. It paves the way for improved diagnosis and tailored treatments.
Effects of Banana Flour on Some Physicochemical, Textural, Bioactive, and Sensory Properties of Gluten‐Free Cookie
Authors: Karaman Kevser , Pinar Hasan , Ciftci Beyza , Kaplan Mahmut 
Published: January 2025

ABSTRACTThe present study aimed to investigate the effects of banana flours obtained from different banana cultivars (Grand Nain (GN), Azman (AZ), and Erdemli (ER)) on some basic physicochemical, bioactive, textural, and sensory properties of the gluten‐free cookie samples by the simplex lattice mixture design approach. Incorporating banana powder into cookie samples resulted in significant changes in the parameters studied. The banana flours’ total dietary fiber and total starch levels ranged between 1.37% and 3.43% and 34.82% and 41.38%, respectively. Erdemli type bananas (ER) were distinguished by their high dietary fiber and resistant starch content as well as their superior bioactive properties. Total phenolic content and antiradical activity of the cookie samples enriched with banana flour were in the range of 376–600 mg GAE/kg, while the antiradical activity values ranged between 8.64% and 59.42%. The hardness of the cookie samples also ranged between 1664.5 and 2605.9 g. According to the results of the optimization, 98.5% ER and 1.5% GN flour mixture could yield the highest response scores. As a conclusion, gluten‐free cookies can be enriched by using banana flour, especially ER‐type ones, to increase the bioactive properties and overall acceptability.
Substitution and Complementarity in the Consumption of Alcohol, Cannabis, and Opium
Authors: Chandra Siddharth , Doshi Gaurav 
Published: January 2025

ABSTRACTUnderstanding the behavior of populations of drug consumers has been and remains a topic of keen interest. Using a unique dataset on 25 districts from Bengal, India, from 1911 to 1925, we analyze whether populations of consumers treat alcohol, cannabis, and opium as economic substitutes or complements in a legal regime. Additionally, we examine responsiveness to prices and income. Our analysis has three main findings. First, we find evidence of substitution between alcohol and cannabis bud. Second, cannabis leaf is a complement for alcohol but a substitute for cannabis bud. Third, we find negative income elasticity for alcohol, cannabis bud, and opium consumption. These findings on the link between consumption patterns and economic factors can guide harm reduction strategies.
The Effects of Hydrological Disasters on the Population's Health in the Northeast Region of Brazil
Authors: Halmenschlager Vinícius , de Almeida Alexandre Nunes , Ribeiro Felipe Garcia , da Trindade Carolina Silva 
Published: January 2025

ABSTRACTThe Northeast region of Brazil is characterized by long periods of drought. However, the region is also frequently affected by floods. The socioeconomic characteristics of the locality make the population more vulnerable to the impacts of these disasters. Therefore, the aim of this article is to investigate the short to long‐term impacts of hydrological disasters in northeastern Brazil on morbidity and mortality rates, by age groups. For this purpose, the difference‐in‐differences method proposed by Callaway and Sant'Anna was applied to a monthly panel data spanning the period from 2000 to 2012. The results indicate that in the short term there is an increase in the mortality rate associated with drowning. In the medium term, there are effects particularly on morbidity rates, with emphasis on leptospirosis and acute respiratory diseases. For the long‐term diseases analyzed, no effects of hydrological disasters were observed.
Impact of Recent Translational and Therapeutic Developments on Clinical Course of BCR::ABL1‐Positive and ‐Negative Myeloproliferative Neoplasms
Authors: Mughal Tariq I. , Mascarenhas John , Rampal Raajit K. , Bose Prithviraj , Lion Thomas , Ajufo Helen , Yacoub Abdulraheem , Meshinchi Soheil , Masarova Lucia , Mesa Ruben , Jamieson Catriona , Barbui Tiziano , Saglio Giuseppe , Van Etten Richard A. 
Published: January 2025

ABSTRACTDespite the study of BCR::ABL1‐positive and ‐negative myeloproliferative neoplasms (MPNs) providing seminal insights into cancer biology, tumor evolution and precision oncology over the past half century, significant challenges remain. MPNs are clonal hematopoietic stem cell‐derived neoplasms with heterogenous clinical phenotypes and a clonal architecture which impacts the often‐complex underlying genetics and microenvironment. The major driving molecular abnormalities have been well characterized, but debate on their role as disease‐initiating molecular lesions continues. The introduction of the ABL1 tyrosine kinase inhibitors have been extremely successful in the treatment of chronic myeloid leukemia with most patients having a near‐normal life expectancy. Similar success has, however, not been achieved for BCR::ABL1‐negative MPNs in terms of disease course modification and most patients remain incurable. In both disease categories, genomic instability seems to increase the risk of disease progression to accelerated/blast phase, which is resistant/refractory to conventional treatment and associated with a poor prognosis. To address some of these issues, the late John Goldman and Tariq Mughal founded a scientific and clinical platform in 2006, the Post‐American Society of Hematology (ASH) MPN workshop, to appraise novel cancer biology, candidate therapeutic targets, treatments and other clinical challenges and pay tribute to all the many scientists and clinicians around the world instrumental to the progress made and continuing advances being made. This paper summarizes some of the recent data discussed at the 18th edition of the workshop and includes reference to some data presented or published after the workshop, including the 26th John Goldman CML conference.
Multidimensional Poverty due to COVID‐19 in Southeast Nigeria: Exploring the Roles of Education, Marital and Employment Status
Authors: Ugwu C.E. , Nwosu O. C. , Oti C. J. 
Published: January 2025

ABSTRACTPoverty as a phenomenon is multidimensional, and its incidence and causes constitute constant debate in the literature of the phenomenon. A crisis such as the Coronavirus Disease 2019 (COVID‐19) and the resultant lockdowns may increase poverty prevalence among citizens and, particularly, certain demographic characteristics in Nigeria. Hence, this study's general objectives were to interrogate the incidence of multidimensional poverty due to the COVID‐19 pandemic in the South‐eastern States of Nigeria, using the roles of educational level, marital status, and employment status of citizens as predictors. The 36 methodology of analysing multidimensional poverty index (MPI) was used in the study, and logistic regression is utilised to assess the determinant of multidimensional poverty. Additionally, an interstate online survey of 1057 participants (using a questionnaire) from five states was employed. The results indicated the prevalence and dynamics of COVID‐19 multidimensional poverty in the study area, with 46.55% constituting the severe poor, 16.84% the poor, 6.71% the near poor, and 29.90% the none poor. There were no major significant differences between the states. Significant predictors of COVID‐19‐related poverty in the study were the secondary school educational status and the employment dynamics of respondents. The implication of the result of the study suggests the application of effective palliative measures towards the vulnerable groups, which contributes to poverty reduction.
Efficacy and safety of Anlotinib in combination with gemcitabine and cisplatin as a first‐line treatment for recurrent or metastatic nasopharyngeal carcinoma: A single‐arm clinical trial
Authors: Xiao Zhehao , Chen Weiling , Du Youqin , Zeng Fanyan , Su Fang , Huang Shiting , Qu Song 
Published: January 2025

AbstractThe effectiveness and safety of combining anlotinib with gemcitabine and cisplatin in the first‐line treatment of recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) have not been definitively established. This research seeks to investigate the potential benefits and risks of utilizing this combination therapy in the first‐line management of R/M NPC. The research involved 22 individuals diagnosed with R/M NPC and who had not undergone any previous treatment. These patients were administered a concomitant therapy of anlotinib, gemcitabine, and cisplatin in cycles occurring every 3 weeks. The primary focus of the study was to assess progression‐free survival (PFS), while secondary endpoints included overall survival (OS), disease control rate (DCR), and objective response rate (ORR). The findings revealed that the median PFS duration for patients with R/M NPC receiving the GPA regimen as a first‐line treatment was 12.6 months, with a 95% confidence interval (CI): 0.1 to 25.2. The median OS was reported as 37.4 months, with 95% CI: 28.0 to 46.8. The DCR in this study was 95.5%, while the ORR was 63.6%. Anlotinib has demonstrated a degree of effectiveness in the initial treatment of R/M NPC, while maintaining an acceptable level of safety.
Abdominal wound dehiscence after appendectomy during pregnancy treated by negative pressure wound therapy with subsequent vaginal delivery: A case report and literature review
Authors: Zapletal Jan , Sehnal Borek , Dvorak Radim , Drienko Miroslav , Vlk Radovan , Halaska Michael J. , Rob Lukas 
Published: January 2025

AbstractNegative pressure wound therapy (NPWT) is a very effective method in the treatment of dehiscent, infected, and non‐healing wounds. Difficult wound healing occurs especially in late pregnancy due to the rapid enlargement of the uterus and the constantly increasing tension of the entire abdominal wall. In cases of dehiscence of the surgical wound during pregnancy, proper subsequent treatment is needed, where it is necessary to consider the safety of the mother as well as the fetus. We report the case of a 30‐week pregnant patient who was surgically treated for acute appendicitis in pregnancy with an open appendectomy approach. Postoperative complications resulted in wound dehiscence with complete defect in fascia, which was treated with negative V.A.C. ATS® Therapy System. The therapy was started in the 30th week of pregnancy and continued until delivery with regular check‐ups and regular redressing of the vacuum‐assisted closure (VAC) system. At 38 weeks of pregnancy, the patient delivered vaginally with continued VAC therapy in situ. The final suture took place 3 days after vaginal delivery. Non‐healing wounds with abdominal wall defects should be treated using a multidisciplinary approach, and NPWT can be used. This therapy can also be used during pregnancy. Vaginal delivery is preferred because it reduces the risk of further formation or deepening of the abdominal wall defect after a sufficient time interval from the start of the treatment. This complex case with a literature review of surgical complications in pregnancy treated with NPWT therapy highlights the advantage of a multidisciplinary approach.
Irrigation rates and frequency affect tall fescue color and weed encroachment
Authors: Kowalewski A. , McDonald B. , Wang R. , Schmid C. , Braithwaite E. , Stock T. 
Published: January 2025

AbstractDrought tolerance in turfgrass species and optimal irrigation strategies are key to addressing the need for water conservation in our landscapes. Preliminary findings on tall fescue [Schedonorus arundinacea (Schreb.) Dumort., nom. Cons] in western Oregon have determined that this species can persist at a high‐quality level with very little evapotranspiration (ET) replacement. Research on perennial ryegrass (Lolium perenne L.) in western Oregon has suggested deficit ET replacement is also a viable weed management tool. Considering these preliminary findings, the objectives of this research were to evaluate the effects of reference evapotranspiration (ETref) replacement levels, irrigation intervals, and a no irrigation control treatment on tall fescue appearance and weed encroachment. This research was conducted in western Oregon on a silty clay loam soil. Factors in this experiment included two irrigation frequencies (once or four times a week) and two ETref replacement rates (45% and 80%) compared to a control treatment (no irrigation). The 80% ETref replacement rate resulted in the greatest turf color, followed closely by the 45% ETref replacement treatment. The no irrigation control treatment was able to sustain acceptable turfgrass color for most of the year, with the exception during the month of August. Tall fescue will remain visually acceptable when soil volumetric water content is maintained around 15% or greater in a silty clay loam. The no irrigation control treatment also produced substantial reductions in weed populations (annual and perennial broadleaf weeds and annual grasses).