bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Imidazolylidene‐Based Mesoionic Carbene–Mn(I) Complex and Its Catalytic Potential in N‐Heteroarene Hydrogenation
Authors: Kumar Ravi , Pandey Madhusudan K. , Pandey Indresh K. , Kumar Abhishek , Choudhury Joyanta 
Published: August 2023

AbstractHerein we report the first mesoionic carbene (MIC)‐Mn(I) complex Mn‐bim‐MICimz derived from imidazolylidene motif. Structurally the octahedral Mn(I) complex Mn‐bim‐MICimz was assembled with an anionic benzimidazolato‐anchored imidazolylidene MIC‐based bidentate ligand (bim‐MICimz) and four CO ligands, as supported by detailed characterization using NMR and FTIR spectroscopy, mass spectrometry, and single crystal X‐ray diffraction study. We reckoned that the bim‐MICimz ligand would provide a robust and stable bonding with the Mn(I) centre, and also enhance electron density at the Mn(I) centre through its stronger σ‐donating/weaker π‐accepting property. These structural and electronic attributes triggered to exploit Mn‐bim‐MICimz in catalytic hydrogenation of N‐heteroarenes, where efficient hydride (Mn−H) delivery is a key step.
Hypouricemia in the emergency department: A retrospective, single‐center study
Authors: Makinouchi Ryuichiro , Koyama Teppei , Machida Shinji , Imai Naohiko 
Published: August 2023

AbstractBackgroundsFew studies have reported the prevalence and characteristics of hypouricemia in the emergency department (ED). We investigated the prevalence and characteristics of hypouricemia in the ED of a university‐affiliated hospital in Japan.MethodsThis is a retrospective cross‐sectional single‐center study. All adult patients (18 years old or older) who had their serum uric acid (SUA) measured at the ED between 2011 and 2021 were included. Information collected included age, sex, SUA, and serum creatinine. Hypouricemia was defined as an SUA level ≦2.0 mg/dL.ResultsA total of 10,551 patients were included in the study. Fifty‐one percent were male. The median SUA levels were significantly higher in men than in women (6.0 [4.8−7.4] vs. 4.7 [3.7−6.1], p < 0.001). The prevalence of hypouricemia was higher in women than in men (2.0% vs. 0.9%, p < 0.001). A possible cause of hypouricemia was identified in 88 patients. Malignancy and diabetes were the major possible cause of hypouricemia (p < 0.001).ConclusionThe distribution of SUA levels and prevalence of hypouricemia differed significantly by sex and age in the ED. Malignancy was the leading cause of hypouricemia in the ED.
Protecting Group‐Free Gold‐Catalyzed Synthesis of 2‐Acylidene‐3‐Oxindoles and Azaaurones via a Double Oxidation Strategy
Authors: Song Xinlong , Zhao Ximei , Zeng Zhongyi , Rominger Frank , Rudolph Matthias , Hashmi A. Stephen K. 
Published: August 2023

AbstractA one‐pot synthesis of 2‐acylidene‐3‐oxindole and azaaurone derivatives starting from O‐alkynylanilines and alkynes is presented. By means of oxidative gold catalysis the two starting materials are transferred to reactive intermediates that in situ form the target products. This double oxidation strategy enables a protecting group‐free step‐economic strategy towards these valuable substrate classes.
Case Report: Unexplained Mild Hypophosphatemia and Very High Serum FGF23 Concentrations
Authors: Bosman Ariadne , Ratsma Danielle MA , van der Eerden Bram CJ , Zillikens M Carola 
Published: August 2023

ABSTRACTFibroblast growth factor (FGF)23 is one of the major regulators of phosphate homeostasis. Hypophosphatemia can lead to muscle weakness, fatigue, and osteomalacia. In the setting of hypophosphatemia, serum FGF23 can be measured to differentiate between FGF23‐mediated and non‐FGF23‐mediated renal phosphate wasting. C‐terminal FGF23 (cFGF23) assays detect both cFGF23 and intact FGF23 (iFGF23). Circulating FGF23 is regulated by 1.25‐dihydroxy‐vitamin D, parathyroid hormone (PTH), serum phosphate, and serum calcium but also by, for example, iron status, inflammation, erythropoietin, and hypoxia‐inducible‐factor‐1‐α. We present the case of a 48‐year‐old woman with unexplained mild hypophosphatemia, very high cFGF23, and normal iFGF23. The patient proved to have an iron deficiency. Iron deficiency alters the iFGF23‐to‐cFGF23 ratio. After initiation of iron treatment, cFGF23 strongly decreased. This case report illustrates the limitation of cFGF23 assays and urges clinicians to be aware that cFGF23 concentrations do not necessarily reflect iFGF23 concentrations and that alternative causes for its elevation should be considered (eg, iron deficiency). © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
Isoliquiritigenin pretreatment regulates ER stress and attenuates cisplatin‐induced nephrotoxicity in male Wistar rats
Authors: Gómez‐Sierra Tania , Ortega‐Lozano Ariadna J. , Rojas‐Morales Pedro , Medina‐Reyes Estefany I. , Barrera‐Oviedo Diana , Pedraza‐Chaverri José 
Published: August 2023

AbstractCisplatin (CP) is a chemotherapeutic drug used to treat solid tumors. However, studies have revealed its nephrotoxic effect. Oxidative stress, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction are involved in CP‐induced renal damage. Thus, preconditioning (hormetic effect) of ER stress is a strategy to prevent CP‐induced renal damage. On the other hand, isoliquiritigenin (IsoLQ) is recognized as a flavonoid with antioxidant properties and an inducer of ER stress. Therefore, we evaluated the ER stress‐inducing capacity of IsoLQ and its possible protective effect against CP‐induced nephrotoxicity in adult male Wistar rats. The findings reflected that IsoLQ pretreatment might decrease renal damage by reducing plasma creatinine and blood urea nitrogen levels in animals with CP‐induced nephrotoxicity. These may be associated with IsoLQ activating ER stress and unfolded protein response (UPR). We found increased messenger RNA levels of the ER stress marker glucose‐related protein 78 kDa (GRP78). In addition, we also found that pretreatment with IsoLQ reduced the levels of CCAAT/enhancer‐binding protein‐homologous protein (CHOP) and X‐box‐binding protein 1 (XBP1) in the renal cortex, reflecting that IsoLQ can regulate the UPR and activation of the apoptotic pathway. Moreover, this preconditioning with IsoLQ of ER stress had oxidative stress‐regulatory effects, as it restored the activity of glutathione peroxidase and glutathione reductase enzymes. Finally, IsoLQ modifies the protein expression of mitofusin 2 (Mfn‐2) and voltage‐dependent anion channel (VDAC). In conclusion, these data suggest that IsoLQ pretreatment has a nephroprotective effect; it could functionally regulate the ER and mitochondria and reduce CP‐induced renal damage by attenuating hormesis‐mediated ER stress.
Francis S. Morrison MD—Tribute to an apheresis leader
Authors: Linz Walter , Thigpen James T. , Strauss Ronald G. 
Published: August 2023

AbstractFrancis S. Morrison MD was among the early developers and promoters of the American Society for Apheresis (ASFA). His work was pivotal in creating a lasting institutional structure from which American apheresis medical practice would develop decades after his death. Francis Morrison is honored each year at the ASFA annual meeting as ASFA awards the Francis S. Morrison MD Memorial Award Lecture to an individual who stands out as among its most accomplished members. This tribute seeks to describe the person and the key accomplishments of Francis S. Morrison in the historical context of a time when the future of apheresis medicine was uncertain.
The role of between‐session homework in cognitive‐behavioral therapy for comorbid obsessive‐compulsive disorder and autism: A case vignette
Authors: Church Molly J. , Mangen Katie H. , Stiede Jordan T. , Spencer Samuel D. , Storch Eric A. 
Published: August 2023

AbstractObjectiveCognitive‐behavioral therapy (CBT), which includes a decided emphasis on exposure and response/ritual prevention (ERP) and between‐session practice of treatment principles, has consistently demonstrated efficacy for the treatment of obsessive‐compulsive disorder (OCD) and is a gold standard, recommended first‐line treatment. CBT with ERP has been successfully adapted to fit the needs of autistic individuals with OCD. The present article provides a brief overview of CBT for OCD and outlines special considerations and adaptations needed when working with patients with OCD and comorbid autism, with an emphasis on the importance of between‐session homework.MethodA case vignette is presented.ResultsThis case study illustrates the role of homework in the exposure‐based treatment of an adult autistic individual with comorbid OCD.ConclusionImplications of this case vignette are discussed, and recommendations are offered for clinicians working with autistic individuals with OCD, especially in regard to bolstering completion of between‐session ERP homework.
Multiple forms of cell death: A focus on the PI3K/AKT pathway
Authors: Xu Jiawei , Li Yu , Kang Meili , Chang Cuicui , Wei Hong , Zhang Chi , Chen Yuhua 
Published: August 2023

AbstractCell death is a natural biological process that occurs in living organisms. Since 1963, extensive research has shed light on the occurrence, progress, and final outcome of cell death. According to different cell phenotypes, it is classified into different types, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and so on. However, regardless of the form of cell death, what we ultimately expect is the disappearance of abnormal cells, such as tumor cells, while normal cells survive. As a result, it is vital to investigate the details of cell death, including death triggers, potent regulators, and executioners. Although significant progress has been made in understanding molecular pathways of cell death, many aspects remain unclear because of the complex regulatory networks in cells. Among them, the phosphoinositide‐3‐kinase (PI3K)/protein kinase B(AKT) pathway is discovered to be a crucial regulator of the cell death process. AKT, as a proto‐oncogene, has become a major focus of attention in the medical community due to its role in regulating a multiplicity of cellular functions counting metabolism, immunity, proliferation, survival, transcription, and protein synthesis. Here, we explored the connection between the PI3K/AKT pathway and cell death, aiming to enhance our comprehension of the mechanism underlying this process. Such knowledge may pave the way for the subsequent development of more effective disease treatments, such as finding suitable targets for drug intervention.
Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram‐Negative Bacterial Infections: A Phase 1b, Open‐Label, Single‐Dose Clinical Trial
Authors: Bradley John S. , Makieieva Nataliia , Tøndel Camilla , Roilides Emmanuel , Kelly Matthew S. , Patel Munjal , Vaddady Pavan , Maniar Alok , Zhang Ying , Paschke Amanda , Chen Luke F. 
Published: August 2023

AbstractImipenem/cilastatin/relebactam is approved for the treatment of serious gram‐negative bacterial infections in adults. This study assessed the pharmacokinetics (PK), safety, and tolerability of a single dose of imipenem/cilastatin/relebactam (with a fixed 2:1 ratio of imipenem/cilastatin to relebactam, and with a maximum dose of 15 mg/kg imipenem and 15 mg/kg cilastatin [≤500 mg imipenem and ≤500 mg cilastatin] and 7.5 mg/kg relebactam [≤250 mg relebactam]) in children with confirmed/suspected gram‐negative bacterial infections receiving standard‐of‐care antibacterial therapy. In this phase 1, noncomparative study (ClinicalTrials.gov identifier, NCT03230916), PK parameters from 46 children were analyzed using both population modeling and noncompartmental analysis. The PK/pharmacodynamic (PD) target for imipenem was percent time of the dosing interval that unbound plasma concentration exceeded the minimum inhibitory concentration (%fT>MIC) of ≥30% (MIC = 2 mcg/mL). For relebactam, the PK/PD target was a free drug area under the plasma concentration–time curve (AUC) normalized to MIC (at 2 mcg/mL) of ≥8.0 (equivalent to an AUC from time zero extrapolated to infinity of ≥20.52 mcg·h/mL). Safety was assessed up to 14 days after drug infusion. For imipenem, the ranges for the geometric mean %fT>MIC and maximum concentration (Cmax) across age cohorts were 56.5%‐93.7% and 32.2‐38.2 mcg/mL, respectively. For relebactam, the ranges of the geometric mean Cmax and AUC from 0 to 6 hours across age cohorts were 16.9‐21.3 mcg/mL and 26.1‐55.3 mcg·h/mL, respectively. In total, 8/46 (17%) children experienced ≥1 adverse events (AEs) and 2/46 (4%) children experienced nonserious AEs that were deemed drug related by the investigator. Imipenem and relebactam exceeded plasma PK/PD targets; single doses of imipenem/cilastatin/relebactam were well tolerated with no significant safety concerns identified. These results informed imipenem/cilastatin/relebactam dose selection for further pediatric clinical evaluation.
Omicron breakthrough infections in wild‐type SARS‐CoV‐2 vaccinees elicit high levels of neutralizing antibodies against pangolin coronavirus GX_P2V
Authors: Lu Shanshan , Luo Shengdong , Bai Bingke , Fan Zhenping , Hong Bixia , Xu Wen , Ma Hongbin , Chen Weiwei , Fan Huahao , Tong Yigang , Song Lihua 
Published: August 2023

AbstractOmicron BF.7 became the predominant SARS‐CoV‐2 variant in Beijing after the abolishment of Zero‐COVID policy in December 2022. The ability of antibodies elicited by BF.7 infection to cross‐react with SARS‐CoV‐2‐like viruses is unknown. This study aimed to investigate the cross‐reactive neutralizing antibodies against SARS‐CoV‐2‐related pangolin coronavirus GX_P2V in sera from vaccinated and/or SARS‐CoV‐2‐infected individuals. All vaccinated individuals who recovered from Omicron BF.7 breakthrough infections exhibited substantially higher levels of neutralizing antibodies against GX_P2V, compared to other subject groups, with a geometric mean titer (GMT) of 362. Uninfected individuals who received four‐mixed‐dose vaccines also demonstrated higher levels of neutralizing antibodies (GMT = 44) against GX_P2V than those uninfected individuals who received two‐ or three‐dose vaccines and those unvaccinated convalescents of wild‐type SARS‐CoV‐2. This study highlights the significance of prior vaccinations with wild‐type SARS‐CoV‐2 vaccines in generating potent cross‐protective immunity against future spillovers of SARS‐CoV‐2‐like viruses.
The I‐STOP Program and Narcotic Prescriptions Following Facial Reconstructive Plastic Surgeries
Authors: Debick Nadia Alexandra , Wilson Danielle , Suryadevara Amar 
Published: August 2023

ObjectivesTo explore the effect of e‐prescribing requirements on narcotic dispersion in New York State.Slicer Dicer was used to identify patient records based on CPT codes.MethodsWe investigated the influence of New York State e‐prescribing requirements on narcotic dispersion following five common facial plastics procedures. Slicer Dicer was used to identify patient records based on CPT codes.We then looked at narcotic prescription rates following those surgeries between March 2014 and March 2018 at an academic institution.ResultsOverall, between March 2014 and March 2018, 76.1% of the sample received a narcotic prescription following a facial reconstructive plastic surgery. Patients who underwent rhinoplasty were most likely to receive a prescription for postoperative narcotics. The implementation of ISTOP, CPT code, use of non‐narcotic adjuvant, and insurance type were each significantly associated with prescription of postoperative narcotics. Surgery time and age in years were significantly associated with prescription of postoperative narcotics. Ultimately, when controlling for the aforementioned clinical and sociodemographic variables included in the study, those who underwent surgery after the implementation of ISTOP were 42.8% less likely to receive a prescription for postoperative narcotics, aOR = 0.572, 95% CI 0.356, 0.919, p = 0.021.ConclusionsNew York State's ISTOP program has succeeded in reducing the number of postoperative narcotic prescriptions following facial plastic reconstructive surgeries at this academic institution. However, opioid medications can still be utilized for postoperative analgesia when clinically appropriate.Level of Evidence3 Laryngoscope, 134:1208–1213, 2024
Energy‐based approach for fastening processes on the example of impulse tightening – possible parameters for extended and tool‐independent fastening quality assessment
Authors: Merten M. , Dawood A. , Mai T. , Fuessel U. 
Published: August 2023

AbstractFür die Montage sicherheitsrelevanter Verschraubungen kommen vorrangig kontinuierlich drehende Werkzeuge zum Einsatz. Ergänzend dazu kann das Wirkprinzip der gesteuerten Impulsschraubtechnik, im Hinblick auf eine mögliche Einsparung der Fertigungszeit bei gleichzeitig hohen Verbindungsqualitäten, eine sinnvolle Alternative darstellen. In der Praxis gestaltet sich die Anwendung pulsender Werkzeuge aufgrund teils fehlender und gleichzeitig sehr umständlicher Vorgehensweisen und Richtlinien für die rückführbare Kalibrierung als schwierig. Auch bedingt die aktuelle Bewertung des maximalen Drehmoments eines Impulses teilweise große Schwankungen in der Abschaltgenauigkeit dieser Werkzeuge. In diesem Zusammenhang bietet die Anwendung der energetischen Betrachtungsweise bei Schraubenverbindungen das Potenzial einer werkzeugunabhängigen Bewertung der Qualität des Montageprozesses. Basierend auf Analysen ablaufender energetischer Umwandlungen vom Eintrag des Antriebsmediums in das Schraubwerkzeug bis hin zur Vorspannkrafterzeugung als Zielfunktion soll die Energie als Größe zur Prozessbewertung befähigt werden. Voraussetzung hierfür ist zunächst ein umfangreiches theoretisches Verständnis für die ablaufenden Prozesse während des pulsenden Energieeintrags, welches es durch praktische Untersuchungen zu verifizieren gilt. Ziel soll es sein, die gesamte Verlaufsform der jeweiligen Impulse für die Prozessbewertung pulsender Werkzeuge zu berücksichtigen sowie die Vergleichbarkeit unterschiedlicher Werkzeugtypen energiebasierend zu ermöglichen. Weiterhin soll dem Anwender durch Aufzeigen der „Strategien“ Leistungsbegrenzung und Überdimensionierung die Nutzung und Parametrierung gesteuerter Impulsschraubtechnik erleichtert werden.
Machinability study of silicon carbide and cenosphere reinforced Al7075 composite using three different tool materials
Authors: Setia Sunil , Chahuan Sant Ram 
Published: August 2023

AbstractThis research conducted a machinability study on Al7075 composite reinforced with nano‐sized (100 nm) silicon carbide and cenosphere (industrial waste) particulates with 1.8 % weight. These composites were fabricated utilizing an ultrasonically assisted stir‐casting setup and scanning electron microscope investigation was conducted to evaluate the dispersion properties of the reinforcement in the matrix phase. During the study, the effect of variation of feed rate, cutting speed and depth of cut on cutting forces and tool tip temperature has been studied. A total of 253 experiments were conducted using three different tool inserts polycrystalline diamond, cermet, and coated carbide under dry cutting conditions. Among the two components of the cutting force, it was noted that the primary cutting force was the largest. A full factorial response surface regression model has been developed and it is found that the regression model can predict cutting force and temperature with fair accuracy.
Photoelectrochemical, optical and magnetic properties of magnetite nanoparticles
Authors: Chetibi L. , Ouazouaz R. , Hamana D. , Achour S. 
Published: August 2023

AbstractMagnetite magnetic nanoparticles are prepared using olive leaf extract as a green reducing and stabilizing agents. After reaction the product is heated up to get rid of the organic compounds and get pure magnetite nanoparticles. Differential scanning calorimetry is used to study the phase transformation as a function of heating temperature. Scanning electron microscope and high resolution transmission electron microscope show spherical and crystallized nanoparticles with a size of 5 nm. X‐ray diffraction and Raman and x‐ray photoelectron spectroscopy indicate the formation of Magnetite phase with high cristallinity and purity. The synthesized Magnetite nanoparticles are semiconductors with gap energy around 2 eV. Observed by transmission electron microscope graphite rods with stacked carbon disks are decorated with the prepared nanoparticles and show enhanced photocurrent. The vibrating sample magnetometer measurements indicate that the prepared Magnetite nanoparticles have superparamagnetic behavior. These results are very promising for clinical and water splitting applications.
Dual‐polarized filtering antenna and its application for compact multi‐array
Authors: Wu Rui , Lin Jian‐Hong , Chen Fu‐Chang , Cao Wei‐Ping , Yuan‐Liu  , Cai Shu‐Ting , Chu Qing‐Xin , Xue Quan 
Published: August 2023

AbstractThis article presents a ±45° dual‐band dual‐polarized filtering antenna. The filtering antenna element is a dual‐polarized patch antenna that loads a parasitic patch with two rectangle slots to achieve compact multi‐array. Multi‐array consists of three 1×2 subarrays arranged, which are designed for 1.8/2.1 GHz FDD band applications. Very close‐arranged antennas exhibit radiation pattern invariance as well as in‐band radiation property. Radiation patterns are conformal with a compact subarray distance of 45 mm (0.29λ0), which is 56% smaller than that of the array using traditional filtering elements. Moreover, the total width is only 180 mm for three subarray‐composed antenna arrays. The average gain is 8.7 dBi with a low profile of 0.069λ0. The proposed array exhibits the filtering property of the subarrays with a very simple structure.
The cumulative school bus routing problem: Polynomial‐size formulations
Authors: Farzadnia Farnaz , Bektaş Tolga , Lysgaard Jens 
Published: August 2023

AbstractThis article introduces the cumulative school bus routing problem, which concerns the transport of students from a school using a fleet of identical buses. The objective of the problem is to select a drop‐off point for each student among potential locations within a certain walking distance and to generate routes such that the sum of arrival times of all students from their school to their homes is minimized. The article describes six polynomial‐size mixed integer linear programming formulations based on original and auxiliary graphs, and the formulations are numerically compared on real instances. The article reports the results of computational experiments performed to evaluate the performance of the proposed models.