bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of students' online teaching satisfaction based on the concept of user experience ——A cross-sectional data study from medical schools in northern China
Authors: Xie Yuzhuo , Li Yuanheng , Wang Yazhou , Zhang Yuwei , Ma Mingxue , Wang Jingzhi , Guo Jiaqi , Shi Jiajun , Zhu Liling , Jiang Deyou , Jiao Mingli 
Published: August 2023

Abstract
Background
This study used the concept of user experience as the core, combined with the concepts of student evaluation and value-added evaluation, to design a course satisfaction questionnaire based on student experience regarding some entries of the Australian CEQ Course Experience Scale and conduct a questionnaire survey on students in two medical colleges in China, To explore the possible relationship between the relevant independent variables dominated by five-dimensional experience and students' overall course satisfaction.
Methods
A questionnaire survey was conducted on 2,504 students from two medical colleges in Heilongjiang, China. SPSS statistical software was used to conduct data difference test and regression analysis, etc., to explore the possible relationship between some basic conditions and subjective experience indicators and students' online education satisfaction.
Results
In a survey of 2,392 students who responded valiantly, it was found that the majority of students (72.62%) were very satisfied with their current teaching. Concrete results indicated that 1) the dimensions of user experience-based student interactive, behavioral, and speculative experiences positively affected overall satisfaction with classes; 2) students’ satisfaction with the drastic changes in education methods in the context of Chinese-style education was generally higher owing to objective factors such as the pandemic; and 3) a correlation existed between some personal factors, such as adaptation to campus life, grade level, relationship with parents, and student experience satisfaction. Other results indicated that students with poor grades may be more satisfied with online education, and online education positively affects promoting educational fairness.
Conclusion
At present, students generally have a high degree of satisfaction with online education. In the future, we will further refine the classification of experience dimensions on the basis of the conclusions of this study and pay attention to students' subjective experience feelings, so as to help steadily improve the effectiveness of education and teaching.
The impact of COVID-19 on management indicators of emergency department in Kowsar Hospital of Sanandaj City
Authors: rezaee Srva , Akhbari Kourosh , Hosseinzadeh Sajjad , Nezakati Aram , Mahmoodi Parvin , Pakniyat Abdolghader 
Published: August 2023

Abstract
Background
There is increasing evidence that patients avoid emergency departments due to fear of contracting COVID-19, which increases morbidity and mortality. To ensure the effectiveness of emergency services, department's performance must be measured. Today, various tools and methods are used to measure the performance indicators of the emergency department.
Methods
The current study is a descriptive-analytical cross-sectional study, which was conducted in the year 1400 in the emergency department of Kowsar hospital in Sanandaj. The research population included all patients admitted through triage from 1397 to 1400. Data were collected using SPSS statistical software version 23 and descriptive statistics (percentage, frequency, mean and standard deviation) and inferential (ANOVA, independent t-test, and post hoc test) were subjected to statistical analysis. A P value of 0.05 was considered.
Results
In the data related to emergency admissions after Corona during the outbreak of the disease, the first, second, third, fourth and fifth periods of the epidemic compared to the same period in the previous year were 48.7, 34.1, 31.7, 25.2, and 16.2, respectively. Percentage decreased. The average age of clients increased from 33.50 to 36.93 during the epidemic. In the study of the gender variable, before covid-19, 56.5% of clients were men, and 43.5% were women. After the pandemic, these percentages reached 62.5% and 37.5%, respectively. The index of assignment within 6 hours averaged 84.69% in 4 years, which has increased after the Covid-19 pandemic. The percentage of patients discharged under 12 hours was also calculated with an average of 94.54% in 4 years, which has decreased after the covid-19 pandemic. The percentage of self-responsible discharges in the emergency department was 40.8% before and 59.2% after the Covid-19 pandemic, which has been increasing. The index of unsuccessful cardiopulmonary resuscitation decreased from 112 cases before the pandemic to 64 cases after. The average duration of triage during four years was calculated as 8.11 minutes, which increased significantly compared to before.
Conclusion
The Covid-19 pandemic has had greatly impacted patient referrals to the emergency department. This research showed that the beginning of the covid-19 pandemic affected emergency management indicators and patients' visits to the emergency room.
Prediction of neurological disorders in HIV-infected persons in Taiwan: a nested case-control study
Authors: Weng Ya-Wei , Lee Susan Shin-Jung , Tsai Hung-Chin , Hsu Chih-Hui , Lin Sheng-Hsiang 
Published: August 2023

Abstract
Background
Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan.
Methods
We identified 30,101 HIV-infected people between 2002 and 2016 from the National Health Insurance Research Database in Taiwan, and analyzed the incidence of neurological disorders. We applied a retrospective, nested case-control study design. The individuals with (case group) and without (control group) a neurological disorder were then matched by age, sex and time. Factors associated with neurological disorders were analyzed using a conditional logistic regression model, and a nomogram was generated to estimate the risk of developing a neurological disorder.
Results
The incidence of neurological disorders was 13.67 per 1000 person-years. The incidence remained stable during the observation period despite the use of early treatment and more tolerable modern anti-retroviral therapy. The conditional logistic regression model identified nine clinical factors and comorbidities that were associated with neurological disorders, namely age, substance use, traumatic brain injury, psychiatric illness, HIV-associated opportunistic infections, frequency of emergency department visits, cART adherence, urbanization, and monthly income. These factors were used to establish the nomogram.
Conclusion
Neurological disorders are still prevalent in HIV-infected people in Taiwan. To efficiently identify those at risk, we established a nomogram with nine risk factors. This nomogram could prompt clinicians to initiate further evaluations and management of neurological disorders in this population.
Three years of COVID-19-related school restrictions and children's mental health in Japan
Authors: Takaku Reo , Shobako Naohisa , Nakata Taisuke 
Published: August 2023

Abstract
During the three years of the COVID-19 pandemic, Japanese children had to continue compliance with restrictive mitigation measures at school, such as eating school lunches silently and wearing masks even during physical exercise classes, despite restrictions having been relaxed worldwide. Excursions and other school events were frequently cancelled, especially in 2020 and 2021. This study aimed to understand how the strict mitigation measures affected children's mental health and well-being, and hence, a retrospective survey on school experiences was conducted. Results revealed school excursion cancellation to be associated with higher risk of developing depressive symptoms (odds ratio [OR] 1.655 [95% confidence interval {CI} 1.194–2.293]), and high cancellation rate of other school events to be associated with dissatisfaction in school experience (OR 1.638 [95% CI 1.214–2.221]). Overall, the study demonstrated that persistent strict mitigation measures at schools could have a cumulative negative impact on children’s mental health and psychological well-being.
The Comparative Effects of Visible Light and UV-A Radiation on the Combined Toxicity of P25 TiO2 Nanoparticles and Polystyrene Microplastics on Chlorella sp
Authors: Rex Camil , Mukherjee Amitava 
Published: August 2023

Abstract
The ubiquitous presence of TiO2 nanoparticles (nTiO2) and microplastics (MPs) in marine ecosystems has raised serious concerns about their combined impact on marine biota. In the natural environment, marine microalgae can interact with mixtures of nTiO2 and MPs under both visible light and UV-A radiation conditions. However, most of the previous toxicity studies employed visible light conditions, so the influence of UV-A radiation on toxicity remains poorly understood. To address this gap, the current study aimed to compare the effects of visible light and UV-A radiation on the combined toxic effects of nTiO2 and polystyrene microplastics (PSMPs) in the marine microalga Chlorella sp using artificial seawater directly as the test medium. Our results demonstrated that under UV-A radiation the algal growth inhibition was significantly enhanced compared to that in visible light conditions. The mixtures of nTiO2 and PSMPs exhibited significant enhanced toxicity than their pristine forms. Specifically, the mixtures of nTiO2 and NH2-functionalized PSMPs (10mg/L) showed higher toxicity to algae than the mixtures with COOH-functionalized PSMPs (10mg/L). Furthermore, UV-A radiation exacerbated the hetero aggregation between algae and pollutants. The photoactive nTiO2, promoted increased production of reactive oxygen species under UV-A exposure resulting in cellular damage, lipid peroxidation, and impaired photosynthesis. The effects were more pronounced in case of the mixtures where PSMPs added to the oxidative stress. The toxic effects of the binary mixtures of nTiO2 and PSMPs were further confirmed through the Field Emission Electron Microscopy, revealing specific morphological abnormalities. This study provides valuable insights into the potential risks associated with the combination of nTiO2 and MPs in marine environments, considering the influence of environmentally relevant light conditions and the test medium.
A national survey on current state and development needs of clinical and academic emergency medicine in China
Authors: Du lanfang , Li Yan , wang Zhenjie , Zhang Guoqiang , Chen Xiaohui , Tian Yingping , Zhu Changju , Zhang Jinsong , Wu Lidong , Li Peiwu , Chen Yuguo , Ji Bing , Pan Shuming , Zeng Jun , Chai Yanfen , Mu Yesai , Zhang Mao , Ma Yu , Lv Chuanzhu , Ma Qingbian 
Published: August 2023

Abstract
Background
To characterize the current state of emergency medicine (EM) development and the needs for advancing EM practice, education and research in China.
Methods
An anonymous electronic survey was conducted by Chinese Society of Emergency Medicine during September to October 2021. The survey contained 30 questions divided into 2 sections: the current state of EM development and the needs for growth.
Results
Finally, 722 hospitals from 26 provinces were included, of 487 were Level III and 235 were Level II hospitals. We found that after 40 years of development, EM had established a mature disciplinary system and refined sub-specialties including cardiopulmonary resuscitation, toxicology, emergencies and disasters and critical care. The training system of emergency professionals had been initially established. 37.8% of emergency departments in Level III hospitals have master's degree program, 8.4% have doctor's degree program, only 2.9% have post-doctoral mobile research stations. Postgraduate curriculums of EM were available in 1/4 of EDs in Level III hospitals. Only 8% have national or provincial key laboratories. In addition to advance clinical practice, there was also a high demand to improve teaching and research capacities, mainly focusing on literature review, research design and delivery, paper writing, standardized training for residents.
Conclusions
EM has built a mature discipline system and refined sub-specialties in China. The training system of emergency professionals had been initially established. In addition to advance clinical specialty, we should also pay attention to the strong need for improving EM education and research capacities.
A 12-year follow up survey of childhood blindness at schools for the blind in Cambodia
Authors: Rogerson Thomas , Ath Sith Sam , Meng Ngy , Casson Robert 
Published: August 2023

Abstract
Background:
Cambodia is a low-income country in South East Asia with a population of 15.5 million people of whom 4.9 million (38%) are under the age of 16. The causes of childhood blindness in Cambodia have not been investigated since the first survey of schools for the blind done in 2009 by our group. Given the large demographic and economic shifts in Cambodia since 2009 it is important to determine if these causes have changed in order to ensure intervention programmes are appropriately targeted. The purpose of the present study is to investigate the prevalences of the causes of childhood blindness at schools for the blind in Cambodia.
Methods:
Students between the ages of 5 and 16years who were attending schools for the blind in Cambodia were examined by a consultant paediatric ophthalmologist and had clinical photographs taken. Distance visual acuity was measured using a logMAR tumbling E chart and the WHO definitions of blindness and severe visual impairment were used. The examining ophthalmologist recorded the anatomical site and aetiology of vision loss using the WHO Prevention of Blindness eye examination record for children. Collected data were compared to a previous survey from 2009.
Results:
Data from 76 students were included for analysis. The most common anatomical location of abnormality causing vision loss was the cornea (n = 20, 33.9%) followed by the lens and retina (n = 11, 18.64% for both). Hereditary factors (n = 29, 49.15%) and childhood diseases (n = 27, 45.76%) were the most common aetiological causes of childhood blindness. The majority (71.19%) of childhood blindness was avoidable. The present study did not demonstrate a significant difference in the causes of childhood blindness compared to 2009.
Conclusions
Corneal pathologies continue to represent the most common cause of vision loss amongst the surveyed population and the majority of causes of childhood blindness continue to be avoidable. These findings will facilitate the development of evidence-based targeted interventional programmes in Cambodia.
Which is More Important, Foreign Direct Investment Inflow or Outflow, on the Pollution of European Union Countries?: Evidence from Panel Fourier Symmetric and Asymmetric Causality
Authors: Tutuncu Asiye , ALTIN Omca , YILDIRIM Sukran SIRKINTIOGLU 
Published: August 2023

Abstract

Uncertainty remains regarding the impact of foreign direct investments on countries' environmental policies and pollution levels. Therefore, this study examines the relationship between foreign direct investment inflows, outflows, and carbon dioxide emissions for EU (European Union) member states. Accordingly, the data for the period 1993–2019 were subjected to the Panel Fourier symmetric and asymmetric causality tests for 21 EU countries. According to the panel Fourier symmetric causality test results, the effect of foreign investment outflows on carbon dioxide emissions is more dominant in general. While there is a bidirectional relationship between these variables in the Austrian and Slovak Republics, there is a unidirectional relationship between foreign investment outflows to carbon dioxide emissions in Belgium, Bulgaria, Cyprus, Ireland, and Portugal. On the other hand, one-way causality was found from foreign investment inflows to carbon dioxide emissions in Belgium, Cyprus, France, Ireland, and Romania and from carbon dioxide emissions to foreign investment inflows in Finland, Greece, and Sweden. According to the panel Fourier asymmetric causality test results, causality between variables is statistically significant in many countries. This shows that the asymmetric relationship is essential for the variables.
Ambulance clinicians implementing evidence-based practice: Mind the Gap! Attitudes, perceptions and experiences of student paramedics.
Authors: Newton Jon , Smith Andrew 
Published: August 2023

Abstract
Background: Evidence-Based-Practice (EBP) represents the conscientious and judicious use of the best contemporaneous evidence in partnership with patient values and clinical expertise to guide healthcare professionals. As a result, EBP is a recommended component of undergraduate education and considered fundamental for improving patient outcomes. Teaching and learning principles have thus become deeply-rooted in higher education curricula, but only in recent years has EBP begun to permeate the world of paramedic practice. Despite this paradigm, impact of EBP may be limited because ambulance clinicians can struggle to implement techniques, as a variety of barriers impact translation and application.
Methods: A survey study aimed to gain insight into the epistemological and metacognitive barriers impacting student experience in order to help improve teaching and learning practices.
Results: A sample of 64 students, across two different undergraduate paramedic science programmes were recruited. 70% of BSc (Hons) students versus 33% of DipHE students agreed to some extent or greater, that EBP represented minimal benefit in real-world practice due to Trust policy and the guidelines set-out by the Joint Royal College Ambulance Liaison Committee (Welch’s t = 2.571, df = 26, p=0.016 two-sided). 25% felt standard operating procedures negatively impacted their ability to implement EBP; and 39% reported their EBP learning had improved their ability to implement improved levels of patient care.
Conclusion: A disparity between theoretical learning and EBP implementation was identified. EBP may not dovetail with standard operating procedure within UK ambulance Trusts, resulting in confusion among student paramedics as to the true worth of EBP.
Identification of Hub Immune-Related Genes and Immune Infiltration in Type A Aortic Dissection by Bioinformatics Analysis
Authors: Leng Jiajie , Luo Yuxiang , Li Letai , Shi Haoming , Zhou Guoxiang , Zhou Kun , Tu Hongwen , Zhang Cheng , Jiang Yingjiu , Tie Hongtao 
Published: August 2023

Abstract
Background: Type A Aortic Dissection (TAAD), a devastating cardiovascular emergency with high incidence, is associated with immune inflammation. Intervention targets and regulatory mechanism of TAAD remain unclear and necessitate further research. Three datasets (GSE153434, GSE52093, GSE190635) of TAAD were downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) were explored, and immune-related genes, WGCNA and DEGs (IRWDEGs) were overlapped. Four hub genes were screened from 132 IRWDEGs by Protein-Protein Interaction (PPI) Network and least absolute shrinkage selection operator (LASSO) constructed by GSE52093 and validated by GSE190635 and GSE153434 merged datasets . The hub genes were further validated by the GSE52093 dataset and in TAAD tissues by using polymerase chain reaction(PCR) . Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and gene set enrichment analysis (GSEA) were constructed to explore potential related signaling pathways. Immune cell infiltration in TAAD was analyzed by ssGSEA, and their association with the four hub genes were explored.
Results: A total of 132 IRWDEGs were overlapped, twelve key modules were screened, and finally 4 hub genes including CCL2, CXCL8, ENG, and TEK were identified. The expression of CCL2, CXCL8 and ENG was predicted to increase, whereas TEK was predicted to decrease. These results were verified in another independent dataset and human TAAD tissues. The hub genes were related to immune infiltration, indicated by type 17 T helper cell, activated dendritic cell, and active B cell.
Conclusion: The effect of CCL2, CXCL8, ENG and TEK in immune infiltration were identified.
Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs
Authors: Zhang Xianglong , Ward Thomas , Leung Louis , Qu Ping-Ping , Zhou Bo , Muench Kristin , Khechaduri Arineh , Plastini Melanie , Charlton Carol , Pattni Reenal , Ho Steve , Ho Marcus , Huang Yiling , Hallmayer Joachim , Mourrain Philippe , Palmer Theo , Urban Alexander 
Published: August 2023

Abstract

Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase the risk for autism spectrum disorders (ASD), schizophrenia, and several other developmental conditions. Here, we investigate the global effects on gene expression and DNA methylation using a 16p11.2 CNV patient-derived induced pluripotent stem cell (iPSC) to induced neuron (iN) cell model system. This approach revealed genome-wide and cell-type specific alterations to both gene expression and DNA methylation patterns and also yielded specific leads on genes potentially contributing to some of the phenotypes in 16p11.2 patients. There is global reprogramming of both the transcriptome and the DNA methylome. We observe sets of differentially expressed genes and differentially methylated regions, respectively, that are localized genome wide and that are shared, and with changes in the same direction, between the deletion and duplication genotypes. The genePCSK9is identified as a possible contributing factor to symptoms seen in carriers of the 16p11.2 CNVs. The protocadherin (PCDH) gene family is found to have altered DNA methylation patterns in the CNV patient samples. The iPSC lines used for this study are available through a repository as a resource for research into the molecular etiology of the clinical phenotypes of 16p11.2 CNVs and into that of neuropsychiatric and neurodevelopmental disorders in general.
Breastfeeding process and anxiety in mothers with covid-19 in the postnatal period: A qualitative study
Authors: Özcan Handan , Güngör Tuana 
Published: August 2023

Abstract

Background
The fear, panic, and uncertainties arising during the Covid-19 period have caused many questions about breastfeeding. This study was conducted to investigate breastfeeding and anxiety in mothers with Covid-19.
Methods
The qualitative research type study was conducted in Istanbul between August and November 2021. The sample of the study consists of Covid-19 positive women breastfeeding their babies in the first six months after birth. Both content and descriptive analysis were used to analyze the data.
Results
The data were analyzed under three main themes. Under the theme of the impact of Covid-19 on breastfeeding, mothers experienced situations like decreased or increased breastfeeding frequency, cessation of breastfeeding, isolation, anxiety about transmission, and expression of milk. They reported that their anxiety in the breastfeeding process was related to the health of the baby, baby care, decreased milk or not breastfeeding, and the Covid-19 period. They used practices such as receiving spousal and professional support, paying attention to isolation, effective communication with the baby, and praying as methods of coping with anxiety.
Conclusion
The study demonstrated that factors like transmission anxiety, decreased breastfeeding frequency, and isolation affected breastfeeding, and mothers were most concerned about the baby’s health.