bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning-based prediction of COVID-19 mortality using immunological and metabolic biomarkers
Authors: Tulu Thomas Wetere , Wan Tsz Kin , Chan Ching Long , Wu Chun Hei , Woo Peter Yat Ming , Tseng Cee Zhung Steven , Vodencarevic Asmir , Menni Cristina , Chan Kei Hang Katie 
Published: February 2023

AbstractCOVID-19 mortality predictionBackground COVID-19 has become a major global public health problem, despite prevention and efforts. The daily number of COVID-19 cases rapidly increases, and the time and financial costs associated with testing procedure are burdensome.Method To overcome this, we aim to identify immunological and metabolic biomarkers to predict COVID-19 mortality using a machine learning model. We included inpatients from Hong Kong’s public hospitals between January 1, and September 30, 2020, who were diagnosed with COVID-19 using RT-PCR. We developed three machine learning models to predict the mortality of COVID-19 patients based on data in their electronic medical records. We performed statistical analysis to compare the trained machine learning models which are Deep Neural Networks (DNN), Random Forest Classifier (RF) and Support Vector Machine (SVM) using data from a cohort of 5,059 patients (median age = 46 years; 49.3% male) who had tested positive for COVID-19 based on electronic health records and data from 532,427 patients as controls.Result We identified top 20 immunological and metabolic biomarkers that can accurately predict the risk of mortality from COVID-19 with ROC-AUC of 0.98 (95% CI 0.96-0.98). Of the three models used, our result demonstrate that the random forest (RF) model achieved the most accurate prediction of mortality among COVID-19 patients with age, glomerular filtration, albumin, urea, procalcitonin, c-reactive protein, oxygen, bicarbonate, carbon dioxide, ferritin, glucose, erythrocytes, creatinine, lymphocytes, PH of blood and leukocytes among the most important biomarkers identified. A cohort from Kwong Wah Hospital (131 patients) was used for model validation with ROC-AUC of 0.90 (95% CI 0.84-0.92).Conclusion We recommend physicians closely monitor hematological, coagulation, cardiac, hepatic, renal and inflammatory factors for potential progression to severe conditions among COVID-19 patients. To the best of our knowledge, no previous research has identified important immunological and metabolic biomarkers to the extent demonstrated in our study.
Single-session repair of multiple pressure ulcers in non-ambulatory patients
Authors: Aysal Bilge Kagan , Nisanci Mustafa 
Published: February 2023

Objective: Pressure ulcers (PUs) are highly prevalent and challenging wounds. In this study, patients with either tetraplegia or paraplegia, all of whom had multiple grade 4 PUs and who underwent single-session surgical treatment were included. In order to increase the mobility of the musculocutaneous flap, the gluteus maximus muscle, which cannot be used by immobile patients, was detached and inserted into the flap. Method: This was a retrospective case series and all PUs were reconstructed within the same surgical session. Results: A total of nine patients participated in the study, all of whom were male. Mean age was 33 years (range: 20–42 years). Mean follow-up period was 14.3 months (range: 9–24 months). All patients had a successful single-session repair of all PUs. Total or partial flap losses were not observed. Mean and total number of reconstructed PUs were 2.55 and 23, respectively. The mean area of reconstructed open wounds per patient was 174.6cm2 and the mean operation duration was 253 minutes. The level of blood loss was acceptable as the decrease in haemoglobin levels was not more than 2g/dl for each patient. Conclusion: Multiple PUs can be repaired in one session using gluteus maximus musculocutaneous flaps in immobile patients. Based on the fact that the gluteus maximus is an essential muscle for ambulation, our approach can only be used in the treatment of patients with irreversible paraplegia or tetraplegia. When all prerequsities are met, the amount of blood loss and operation duration are acceptable, and returning the patient to a wound-free state can be achieved more quickly compared to multi-session repairs. Air-fluidised beds are vital tools for accomplishing single session repairs of multiple PUs. The data shows that the approach is safe and can be used in patients with multiple PUs.
Circumcision wound dressing with octylcyanoacrylate tissue adhesive
Authors: Lau Weida , Teo Chang Peng Colin 
Published: February 2023

Objective: Circumcision wounds are commonly dressed with paraffin gauze dressings. Octylcyanoacrylate tissue adhesive (Dermabond; Ethicon, US) is increasingly being used for wound closure, as well as wound dressing. This study compared the outcomes of tissue adhesive dressing versus paraffin gauze dressing for circumcision wounds. Method: Adult male patients undergoing circumcision were randomised into two groups: tissue adhesive dressing (study group) or paraffin gauze dressing (control group). They were followed up at two weeks and at two months after surgery. The primary objective of this study was to determine the difference in patient-reported dressing satisfaction at two week follow-up. Our secondary outcomes included operation time, postoperative pain, postoperative complications, patient-reported cosmetic satisfaction, surgeon-reported cosmetic satisfaction, and surgeon-reported objective measure of cosmetic outcome using a validated scale. Results: A cohort of 40 patients was randomised into two equal groups, study and control. Tissue adhesive dressing was associated with a significantly better patient-reported dressing satisfaction, with a mean Likert scale score of 4.53±0.51 for the study group versus 3.20±1.24 for the control group (p<0.001). It was also associated with a significantly better patient-reported cosmetic satisfaction of 4.58±0.51 versus 4.00±1.12 (p<0.05), respectively. There was no difference in operation time, postoperative pain, postoperative complications or surgeon-reported cosmetic outcomes. Conclusion: Tissue adhesive dressing is an acceptable alternative to paraffin gauze dressing for circumcision wounds. This option should be offered to all patients undergoing circumcision.
Topical oxygen therapy in acute traumatic musculoskeletal wounds of the foot and ankle
Authors: Kamal Sushil , Sehgal Apoorv , Shahi Pratyush , Prakash Chaitanya , Saurav Shivam , Bansal Kuldeep 
Published: February 2023

Objective: To quantify the reduction in wound size and change in wound quality following low-cost topical oxygen therapy (TOT) in patients with acute traumatic musculoskeletal wounds of the foot and ankle. Method: This prospective interventional study included patients with acute traumatic musculoskeletal wounds of the foot and ankle of <3 weeks' duration after they had undergone debridement and required subsequent wound coverage. A sterile C-Arm cover was used to cover the wound and 100% oxygen was administered at 1 atm, at a rate of 10l/min for 90 minutes on each of four consecutive days, through a suction catheter connected to an oxygen cylinder. The cycle was repeated after a three-day break. Wound surface area (by plotting on graph paper) and wound quality (by modified wound infection checklist score and swabs for culture and Gram staining) were assessed before and after TOT application. Results: The study cohort included 20 patients ≥18 years of age. There was a statistically significant (p<0.001) reduction in mean wound surface area from 79.3cm2 at baseline to 69.6cm2 after two cycles of TOT. The mean modified wound infection checklist score was 13.6 and 0.8, respectively, before and after two cycles of TOT, suggesting statistically significant improvement (p=0.02) in wound quality. All patients showed no growth in their wound culture after TOT. Conclusion: TOT appears to be a promising and cost-effective alternative in the management of traumatic wounds. However, future studies with larger sample sizes and control groups for comparison are needed to establish the benefit of TOT in acute traumatic musculoskeletal wounds.
Continuous glucose monitoring for type 1 diabetes
Authors: Gordon Charlotte 
Published: February 2023

Continuous glucose monitoring (CGM) is now a standard of care technology, which enables people living with type 1 diabetes to quickly monitor and manage their glucose levels without frequent, painful, finger-prick testing. This article will provide an overview of CGM technologies, including the most common types of devices, the data generated and information regarding access to these devices via NHS funding, alongside guidance for CGM use in clinical practice. Diabetes technologies are developing at pace, and so practice nurses will increasingly encounter people using CGM. Continuous glucose monitoring is now available to all those living with type 1 diabetes. Charlotte Gordon provides an overview of the technology for nurses working in general practice
Exploring health care professionals’ experiences of supporting LGBTQ+ patients: a qualitative study
Authors: Pearce Chelsea , Di Lorito Claudio 
Published: February 2023

Background: Patients from the LGBTQ+ community report negative healthcare experiences, such as healthcare professionals (HCPs) making assumptions about their identities. Research shows that HCPs report not having enough knowledge to facilitate an open conversation with patients from the LGBTQ+ community, leading to patients feeling ignored. Aims: To explore HCPs’ experiences of supporting patients from the LGBTQ+ community. Method: Semi-structured interviews were conducted with HCPs recruited from the research teams’ professional network. Data were analysed using deductive thematic analysis. Findings: HCPs reported positive and negative experiences, as well as a variety of barriers and facilitators to effective communication, with patients from the LGBTQ+ community. HCPs discussed how clinical practice could improve, for example, by developing more inclusive training that is specific to the HCPs’ clinical group. Conclusion: HCP training needs to be more inclusive of LGBTQ+ identities. It should be tailored to the HCPs’ patient group as this better reflects the varied needs of different clinical groups. Chelsea Pearce and Claudio di Lorito explore health care professionals’ experiences of supporting LGBTQ+ patients
Autonomy-supportive sexual health communication and sexual health behaviors for black and Latino MSM in the House Ball Community: Protocol for a social network analysis and exploratory structural equation model
Authors: Smith Martez D. R. , Leblanc Natalie M. , Nelson LaRon E. , McMahon James M. 
Published: February 2023

Background
Black and Latino men who have sex with men (MSM) have the highest risk of HIV of any group in the U.S. Prevalence could be even higher among Black and Latino MSM belonging to the House Ball Community (HBC), an understudied community comprised primarily of Black and Latino sexual and gender minorities, with HIV prevalence from non-probability samples ranging from 4% to 38%.

Objectives
Basic Psychological Needs Theory will be utilized to understand how sexual health communication (SHC) influences sexual health behaviors of HBC-MSM. The proposed study will advance this goal by describing characteristics of SHC embedded within social and sexual networks, and identifying the effects of SHC on sexual health behaviors among a sample of Black and Latino HBC-MSM.

Methods
This study entails cross-sectional quantitative survey design with internet-based data collection to test a theory-driven model of the effects of autonomy supportive communication on sexual health behaviors. Respondent-driven sampling (RDS) and internet driven sampling (ID) will be used to recruit a sample of 200 HBC-MSM. We will utilize egocentric network analysis to describe (a) the HBC-specific social and/or sexual network members who provide SHC; (b) the degree of autonomy support provided by network members, and (c) the sexual health behaviors characterizing the sample of HBC-MSM. Structural equation modeling (SEM) will be performed to test associations between autonomy supportive sexual health communication (independent variable) and sexual health behaviors (outcome), with needs satisfaction and intrinsic motivation as intervening mediators.

Discussion
Such knowledge is necessary to expand understanding of how SHC impacts sexual health behaviors for HBC-MSM. The study provides an critical perspective on sexual health behaviors and motivations as participants operate in HBC. Knowledge generated from this study will help improve current HIV prevention interventions, as well as inform the development of future interventions, tailored to HBC-MSM.
Strategies to increase uptake of voluntary medical male circumcision among men aged 25–39 years in Nyanza Region, Kenya: Results from a cluster randomized controlled trial (the TASCO study)
Authors: Grund Jonathan M. , Onchiri Frankline , Mboya Edward , Ussery Faith , Musingila Paul , Ohaga Spala , Odoyo-June Elijah , Bock Naomi , Ayieko Benard , Agot Kawango 
Published: February 2023

Introduction
Voluntary medical male circumcision (VMMC) for HIV prevention began in Nyanza Region, Kenya in 2008. By 2014, approximately 800,000 VMMCs had been conducted, and 84.9% were among males aged 15–24 years. We evaluated the impact of interpersonal communication (IPC) and dedicated service outlets (DSO) on VMMC uptake among men aged 25–39 years in Nyanza Region.

Materials and methods
We conducted a cluster randomized controlled trial in 45 administrative Locations (clusters) in Nyanza Region between May 2014 and June 2016 among uncircumcised men aged 25–34 years. In arm one, an IPC toolkit was used to address barriers to VMMC. In the second arm, men were referred to DSO that were modified to address their preferences. Arm three combined the IPC and DSO arms, and arm four was standard of care (SOC). Randomization was done at Location level (11–12 per arm). The primary outcome was the proportion of enrolled men who received VMMC within three months. Generalized estimating equations were used to evaluate the effect of interventions on the outcome.

Results
At baseline, 9,238 households with men aged 25–39 years were enumerated, 9,679 men were assessed, and 2,792 (28.8%) were eligible. For enrollment, 577 enrolled in the IPC arm, 825 in DSO, 723 in combined IPC + DSO, and 667 in SOC. VMMC uptake among men in the SOC arm was 3.2%. In IPC, DSO, and combined IPC + DSO arms, uptake was 3.3%, 4.5%, and 4.4%, respectively. The adjusted odds ratio (aOR) of VMMC uptake in the study arms compared to SOC were IPC aOR = 1.03; 95% CI: 0.50–2.13, DSO aOR = 1.31; 95% CI: 0.67–2.57, and IPC + DSO combined aOR = 1.31, 95% CI: 0.65–2.67.

Discussion
Using these interventions among men aged 25–39 years did not significantly impact VMMC uptake. These findings suggest that alternative demand creation strategies for VMMC services are needed to reach men aged 25–39 years.

Trial registration
clinicaltrials.gov identifier: NCT02497989.
Digital technology and patient and public involvement (PPI) in routine care and clinical research—A pilot study
Authors: Chen Yang , Hosin Ali A. , George Marc J. , Asselbergs Folkert W. , Shah Anoop D. 
Published: February 2023

Background
Patient and public involvement (PPI) has growing impact on the design of clinical care and research studies. There remains underreporting of formal PPI events including views related to using digital tools. This study aimed to assess the feasibility of hosting a hybrid PPI event to gather views on the use of digital tools in clinical care and research.

Methods
A PPI focus day was held following local procedures and published recommendations related to advertisement, communication and delivery. Two exemplar projects were used as the basis for discussions and qualitative and quantitative data was collected.

Results
32 individuals expressed interest in the PPI day and 9 were selected to attend. 3 participated in person and 6 via an online video-calling platform. Selected written and verbal feedback was collected on two digitally themed projects and on the event itself. The overall quality and interactivity for the event was rated as 4/5 for those who attended in person and 4.5/5 and 4.8/5 respectively, for those who attended remotely.

Conclusions
A hybrid PPI event is feasible and offers a flexible format to capture the views of patients. The overall enthusiasm for digital tools amongst patients in routine care and clinical research is high, though further work and standardised, systematic reporting of PPI events is required.
The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy
Authors: Chanidkul Piyachat , Sribenjalak Dueanchonnee , Charoenngam Nipith , Pongchaiyakul Chatlert 
Published: February 2023

Purpose
To determine the proportion of postmenopausal Thai women who would be classified as having high risk of fracture and eligible for anti-osteoporosis therapy according to the National Osteoporosis Foundation (NOF) criteria.

Methods
Postmenopausal Thai women aged 40–90 years who had been screened for osteoporosis during 2014–2019 were recruited. Demographic data and osteoporosis risk factors were collected based on the Fracture Risk Assessment Tool (FRAX) questionnaire. Bone mineral density (BMD) at the femoral neck and lumbar spine measured using dual energy X-ray absorptiometry. Ten-year probabilities of hip and major osteoporotic fracture (MOF) were calculated based on the Thai FRAX model with BMD. The study’s protocol was approved by the Institutional Ethical Committee (HE581241).

Results
A total of 3,280 postmenopausal women were included. The mean ± SD age was 63.6 ± 10.1 years. A total of 170 (5.2%) participants had a history of hip and/or vertebral fracture. After excluding these participants with fracture history, 699 (21.3%) had osteoporosis, 355 (10.8%) had osteopenia with high risk of fracture (FRAX 10-year probability of hip fracture ≥ 3% and/or MOF ≥ 20%), 1192 (36.3%) had osteopenia with low risk of fracture (FRAX 10-year probability of hip fracture < 3% and MOF < 20%) and 864 (26.3%) had normal BMD. Taken together, a total of 1,224 (37.3%) participants would be eligible for anti-osteoporosis therapy (prior fracture, osteoporosis or osteopenia with high risk of fracture).

Conclusion
The prevalence of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy was 37.3%.
Does prior vaccination affect the immune response to seasonal influenza vaccination among older adults? Findings from a prospective cohort study in a Northeastern Province of Thailand
Authors: Praphasiri Prabda , Prasert Kriengkrai , Shrestha Manash , Ditsungnoen Darunee , Chittaganpich Malinee , Chawalchitiporn Sutthinan , Dawood Fatimah S. , Sirilak Supakit , Mott Joshua A. 
Published: February 2023

Background
We measured the immunogenicity of seasonal trivalent inactivated influenza vaccines (IIV3) among older Thai adults and the effect of one-year prior vaccination status on immune responses.

Method
Adults aged ≥65 years (n = 370) were vaccinated with Southern Hemisphere IIV3 in 2015. Hemagglutination inhibition assays were performed using goose red blood cells on sera collected from the participants at baseline and after 1, 6, and 12 months of vaccination. Prior year vaccination (in 2014) was verified with the national health security office database. We analyzed the associations between prior vaccination and geometric mean titers (GMT) at each time point using generalized linear regression on logged transformed titers, and seroprotection and seroconversion using Log-binomial regression.

Results
At baseline, previously vaccinated participants (n = 203) had a significantly higher GMT and seroprotection against all three influenza strains than those previously unvaccinated (n = 167) (all p-values <0.001). Seroprotection rates were similar after one month in both groups for A(H1N1)pdm09 (adjusted risk ratio [aRR] 1.10, 95% CI 0.97–1.25), and A(H3N2) (aRR 1.08, 95% CI 0.87–1.33), but higher in previously vaccinated persons for B (aRR 1.20, 95% CI 1.08–1.32). At 12 months, 50% or more had seroprotection in previously vaccinated group with no difference between previously vaccinated or unvaccinated persons. Seroconversion was lower in the previously vaccinated group for A(H1N1)pdm09 (aRR 0.62, 95% CI 0.43–0.89), but did not differ between the two groups for A(H3N2) (aRR 0.94, 95% CI 0.69–1.28) and B (aRR 0.85, 95% CI 0.60–1.20).

Conclusion
Influenza vaccination elicited good humoral response in older Thai adults. While seroconversion seemed attenuated in persons previously vaccinated for influenza A(H1N1)pdm09 (the only vaccine strain not to change), this was not apparent for influenza A(H3N2) and B, and prior vaccination was not associated with any inhibition in seroprotection.
Human Resource Development within the Sustainability Science Framework
Authors: El-Fekey Sherine Fathy , Mostafa Bassant Adel 
Published: February 2023

The United Nations 2030 17 Sustainable Development Goals are anticipated to make a significant contribution to humanity's well-being (SDGs). The agenda is founded on the triple bottom line (TBL) idea, according to which social inclusion and environmental sustainability are essential for continued economic development. In order to determine the crucial role that human resource development (HRD) plays in sustainability, this study will review relevant academic literature and update the TBL model to include and emphasize the HRD dimension and the dynamism and resilience of the sustainability framework; and to fill the literature gap in relating HRD to sustainability. This paper takes a deductive approach and is based on reviewing state-of-the-art literature to develop a new conceptual framework integrating HRD into the sustainability model. Hence, relevant studies are selected; based on criteria, mainly from refereed journals in the fields of human resources and sustainability. These studies will be critically analyzed to highlight their main focus, findings, and key contributions to the proposed framework. The paper proposed a conceptual framework that is global, resilient, and dynamic in nature to face today’s challenges. This framework aims to capitalize on the previous researchers’ designed sustainability models, try to complement some of these models’ perceived limitations, and shed light on HRD multi-level incorporations in sustainability.
The paper proposed a “Global Dynamic Sustainable Humanity Framework” that stresses on (1) Integrating HRD into the TBL sustainability model; (2) Embedding the resilience concept in the framework; (3) Transforming the sustainability framework into a dynamic one; (4) take the sustainability framework to a global level. The paper also suggested raising “sustainable humanity” awareness by introducing a paradigm shift - from a traditional environment to a sustainable environment – as a prerequisite to the success and effectiveness of the proposed framework. The paper integrated rich theoretical perspectives and sustainability models of different studies into one coherent framework. It also filled the gap in the literature studying the HRD's crucial role in sustainable development. The proposed framework enriches and enables HRD practitioners to play an integral role in sustainable development on the individual, organizational and societal levels – nationally and globally. Their role as change catalysts is crucial in applying the proposed Global Dynamic Sustainable Humanity Framework, raising people's awareness of sustainability, help making a paradigm shift towards sustainability.
Keywords: Human Resource Development; Sustainability; Triple Bottom Line; Global Sustainability Framework; Resilient; Dynamic