bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesophotic vs. shallow water reefs: ecosystem connectivity in the Silurian of Gotland
Authors: Łuczyński Piotr , Skompski Stanisław , Zapalski Mikołaj K. 
Published: September 2023

AbstractThe Lower Silurian Visby Beds (ca. 430 Ma) exposed on the island of Gotland (Sweden) yield the oldest so far described MCE’s (mesophotic coral ecosystems). Several basic questions concerning these ecosystems, including their extent, positioning, and particularly their spatial relation and affinity with the shallow water reefs, remain unanswered. We describe a deeply incised erosional channel infilled by redeposited detrital and biodetrital material including corals and stromatoporoids, which represents a unique example of a fossil depositional structure connecting shallow- and deep-water reef environments of that time. The mesophotic environment is embodied by limestones and marls, in which the channel is incised, while the shallow water habitats are represented by the redeposited material infilling the channel. The erosional channel contains material derived from hypothetical adjacent shallow-water reefal settings, which indicates that it served as an interconnecting zone between shallow- and deep-water benthic communities. The vertical connectivity of the shallow-water reefs and the adjacent mesophotic ecosystems results in a significant taxonomic overlap between these communities. This is especially important when taking into account that the Visby Beds are the oldest example of a fossil mesophotic ecosystem described so far. This indicates that the development of the earliest mesophotic ecosystems should not be attributed solely to gradual expansion of corals and stromatoporoids into greater depths, but probably took place also by means of redistribution of shallow water taxa during high-energy sedimentary events.
State of the art and future challenges of urethra-sparing stereotactic body radiotherapy for prostate cancer: a systematic review of literature
Authors: Le Guevelou Jennifer , Bosetti Davide Giovanni , Castronovo Francesco , Angrisani Antonio , de Crevoisier Renaud , Zilli Thomas 
Published: September 2023

Abstract
Purpose
Doses delivered to the urethra have been associated with an increased risk to develop long-term urinary toxicity in patients undergoing stereotactic body radiotherapy (SBRT) for prostate cancer (PCa). Aim of the present systematic review is to report on the role of urethra-sparing SBRT (US-SBRT) techniques for prostate cancer, with a focus on outcome and urinary toxicity.

Method
A systematic review of the literature was performed on the PubMed database on May 2023. Based on the urethra-sparing technique, 13 studies were selected for the analysis and classified in the two following categories: “urethra-steering” SBRT (restriction of hotspots to the urethra) and “urethra dose-reduction” SBRT (dose reduction to urethra below the prescribed dose).

Results
By limiting the urethra Dmax to 90GyEQD2 (α/β = 3 Gy) with urethra-steering SBRT techniques, late genitourinary (GU) grade 2 toxicity remains mild, ranging between 12.1% and 14%. With dose-reduction strategies decreasing the urethral dose below 70 GyEQD2, the risk of late GU toxicity was further reduced (< 8% at 5 years), while maintaining biochemical relapse-free survival rates up to 93% at 5 years.

Conclusion
US-SBRT techniques limiting maximum doses to urethra below a 90GyEQD2 (α/β = 3 Gy) threshold result in a low rate of acute and late grade ≥ 2 GU toxicity. A better understanding of clinical factors and anatomical substructures involved in the development of GU toxicity, as well as the development and use of adapted dose constraints, is expected to further reduce the long-term GU toxicity of prostate cancer patients treated with SBRT.
Management of adhesive small bowel obstruction: the results of a large retrospective study
Authors: Maienza E. , Godiris-Petit G. , Noullet S. , Menegaux F. , Chereau N. 
Published: September 2023

Abstract
Background
Postoperative adhesive small bowel obstruction (SBO) is a frequent cause of hospital admission in a surgical department. Emergency surgery is needed in a majority of patients with bowel ischemia or peritonitis; most adhesive SBO can be managed nonoperatively. Many studies have investigated benefits of using oral water-soluble contrast to manage adhesive SBO. Treatment recommendations are still controversial.

Methods
We conducted an observational retrospective monocentric study to test our protocol of management of SBO using Gastrografin®, enrolling 661 patients from January 2008 to December 2021. An emergency surgery was performed in patients with abdominal tenderness, peritonitis, hemodynamic instability, major acute abdominal pain despite gastric decompression, or CT scan findings of small bowel ischemia. Nonoperative management was proposed to patients who did not need emergency surgery. A gastric decompression with a nasogastric tube was immediately performed in the emergency room for four hours, then the nasogastric tube was clamped and 100 ml of nondiluted oral Gastrografin® was administered. The nasogastric tube remained clamped for eight hours and an abdominal plain radiograph was taken after that period. Emergency surgery was then performed in patients who had persistent abdominal pain, onset of abdominal tenderness or vomiting during the clamping test, or if the abdominal plain radiograph did not show contrast product in the colon or the rectum. In other cases, the nasogastric tube was removed and a progressive refeeding was introduced, starting with liquid diet.

Results
Seventy-eight percent of patients with SBO were managed nonoperatively, including 183 (36.0%) who finally required surgery. Delayed surgery showed a complete small bowel obstruction in all patients who failed the conservative treatment, and a small bowel resection was necessary in 19 patients (10.0%): among them, only 5 had intestinal ischemia.

Conclusions
Our protocol is safe, and it is a valuable strategy in order to accelerate the decision-making process for management of adhesive SBO, with a percentage of risk of late small bowel resection for ischemia esteemed at 0.9%.
Diagnosing post-capillary hypertension in patients with left heart disease: impact of new guidelines
Authors: Güder Gülmisal , Reiter Theresa , Fette Georg , Hundertmark Moritz , Frantz Stefan , Morbach Caroline , Störk Stefan , Held Matthias 
Published: September 2023

Abstract
Background
In 2022, the definition of pulmonary hypertension (PH) in the presence of left heart disease was updated according to the new joint guidelines of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). The impact of the new ESC/ERS definition on the prevalence of post-capillary PH (pc-PH) and its subgroups of isolated post-capillary (Ipc-PH) and combined pre- and post-capillary PH (Cpc-PH) in patients with left heart disease is unclear.

Methods
We retrospectively identified N = 242 patients with left heart disease with available data on right heart catheterisation (RHC) and cardiac magnetic resonance imaging (CMR). The proportion of pc-PH and its subgroups was calculated according to the old and new ESC/ERS PH definition. As the old definition did not allow the exact allocation of all patients with pc-PH into a respective subgroup, unclassifiable patients (Upc-PH) were regarded separately.

Results
Seventy-six out of 242 patients had pc-PH according to the new ESC/ERS definitions, with 72 of these patients also meeting the criteria of the old definition. Using the old definition, 50 patients were diagnosed with Ipc-PH, 4 with Cpc-PH, and 18 with Upc-PH. Applying the new definition, Ipc-PH was diagnosed in 35 patients (4 newly), and Cpc-PH in 41 patients. No CMR parameter allowed differentiating between Ipc-PH and Cpc-PH, regardless of which guideline version was used.

Conclusion
Applying the new ESC/ERS 2022 guideline definitions mildly increased the proportion of patients diagnosed with pc-PH (+ 5.5%) but markedly increased Cpc-PH diagnoses. This effect was driven by the allocation of patients with formerly unclassifiable forms of post-capillary PH to the Cpc-PH subgroup and a significant shift of patients from the Ipc-PH to the Cpc-PH subgroup.

Graphical abstract
Combining different ion-selective channelrhodopsins to control water flux by light
Authors: Lin Fei , Tang Ruijing , Zhang Chong , Scholz Nicole , Nagel Georg , Gao Shiqiang 
Published: September 2023

AbstractWater transport through water channels, aquaporins (AQPs), is vital for many physiological processes including epithelial fluid secretion, cell migration and adipocyte metabolism. Water flux through AQPs is driven by the osmotic gradient that results from concentration differences of solutes including ions. Here, we developed a novel optogenetic toolkit that combines the light-gated anion channel GtACR1 either with the light-gated K+ channel HcKCR1 or the new Na+ channelrhodopsin HcNCR1 with high Na+ permeability, to manipulate water transport in Xenopus oocytes non-invasively. Water efflux through AQP was achieved by light-activating K+ and Cl- efflux through HcKCR1 and GtACR1. Contrarily, when GtACR1 was co-expressed with HcNCR1, inward movement of Na+ and Cl- was light-triggered, and the resulting osmotic gradient led to water influx through AQP1. In sum, we demonstrate a novel optogenetic strategy to manipulate water movement into or out of Xenopus oocytes non-invasively. This approach provides a new avenue to interfere with water homeostasis as a means to study related biological phenomena across cell types and organisms.
CHD7 variants associated with hearing loss and enlargement of the vestibular aqueduct
Authors: Roux Isabelle , Fenollar-Ferrer Cristina , Lee Hyun Jae , Chattaraj Parna , Lopez Ivan A. , Han Kyungreem , Honda Keiji , Brewer Carmen C. , Butman John A. , Morell Robert J. , Martin Donna M. , Griffith Andrew J. 
Published: September 2023

AbstractEnlargement of the endolymphatic sac, duct, and vestibular aqueduct (EVA) is the most common inner ear malformation identified in patients with sensorineural hearing loss. EVA is associated with pathogenic variants in SLC26A4. However, in European–Caucasian populations, about 50% of patients with EVA carry no pathogenic alleles of SLC26A4. We tested for the presence of variants in CHD7, a gene known to be associated with CHARGE syndrome, Kallmann syndrome, and hypogonadotropic hypogonadism, in a cohort of 34 families with EVA subjects without pathogenic alleles of SLC26A4. In two families, NM_017780.4: c.3553A > G [p.(Met1185Val)] and c.5390G > C [p.(Gly1797Ala)] were detected as monoallelic CHD7 variants in patients with EVA. At least one subject from each family had additional signs or potential signs of CHARGE syndrome but did not meet diagnostic criteria for CHARGE. In silico modeling of these two missense substitutions predicted detrimental effects upon CHD7 protein structure. Consistent with a role of CHD7 in this tissue, Chd7 transcript and protein were detected in all epithelial cells of the endolymphatic duct and sac of the developing mouse inner ear. These results suggest that some CHD7 variants can cause nonsyndromic hearing loss and EVA. CHD7 should be included in DNA sequence analyses to detect pathogenic variants in EVA patients. Chd7 expression and mutant phenotype data in mice suggest that CHD7 contributes to the formation or function of the endolymphatic sac and duct.
LET-Net: locally enhanced transformer network for medical image segmentation
Authors: Ta Na , Chen Haipeng , Liu Xianzhu , Jin Nuo 
Published: September 2023

AbstractMedical image segmentation has attracted increasing attention due to its practical clinical requirements. However, the prevalence of small targets still poses great challenges for accurate segmentation. In this paper, we propose a novel locally enhanced transformer network (LET-Net) that combines the strengths of transformer and convolution to address this issue. LET-Net utilizes a pyramid vision transformer as its encoder and is further equipped with two novel modules to learn more powerful feature representation. Specifically, we design a feature-aligned local enhancement module, which encourages discriminative local feature learning on the condition of adjacent-level feature alignment. Moreover, to effectively recover high-resolution spatial information, we apply a newly designed progressive local-induced decoder. This decoder contains three cascaded local reconstruction and refinement modules that dynamically guide the upsampling of high-level features by their adaptive reconstruction kernels and further enhance feature representation through a split-attention mechanism. Additionally, to address the severe pixel imbalance for small targets, we design a mutual information loss that maximizes task-relevant information while eliminating task-irrelevant noises. Experimental results demonstrate that our LET-Net provides more effective support for small target segmentation and achieves state-of-the-art performance in polyp and breast lesion segmentation tasks.
Universitätslehrgang Substanzgebrauchsstörungen
Authors: Sitte Harald H. , Willeit Matthäus 
Published: September 2023

ZusammenfassungDer Universitätslehrgang Substanzgebrauchsstörungen (SGS) widmet sich einem zunehmenden gesellschaftlich und klinisch relevanten Phänomen und möchte den teilnehmenden Studierenden einen rationalen und evidenzbasierten Zugang zu Substanzgebrauch und Menschen mit SGS vermitteln. Es sollen psychiatrische, pharmakologische, neurowissenschaftliche und soziale Grundlagen zu SGS erlernt werden. Weiters sollen evidenzbasierte Kenntnisse über genuine und vermeidbare medizinische Risiken von Gebrauch und Entzug einzelner Substanzen, rechtliche Grundlagen im Umgang mit Suchtmitteln oder psychotropen Substanzen sowie Intoxikationen und Folgeschäden durch Substanzen erarbeitet werden. Ein praxisbezogener Teil sowie die Anwendung von wissenschaftlichen Methoden zur Erarbeitung einer möglichst praxisbezogenen Masterarbeit werden die berufsbegleitende Ausbildung abrunden.
Past attachment experiences, the potential link of mentalization and the transmission of behavior to the child by mothers with mental health problems: cross-sectional analysis of a clinical sample
Authors: Mattheß Janna , Koch Gabriele , Keil Thomas , Roll Stephanie , Berghöfer Anne , Ludwig-Körner Christiane , Schlensog-Schuster Franziska , Sprengeler Mona Katharina , von Klitzing Kai , Kuchinke Lars 
Published: September 2023

AbstractMaternal capacity to mentalize (= reflective functioning, RF), secure attachment and emotionally available parenting has an impact on the child’s development. The transmission of mothers’ past attachment experiences gained with both her caregivers in her own childhood and the impact on current mother–child interaction is part of the ‘transmission gap.’ This study explores the transgenerational transmission mechanisms and the potential moderating effect of RF in a clinical sample of 113 mother–child dyads suffering from mental health problems. In a cross-sectional study, the associations between maternal attachment experiences, RF (coded based on Adult Attachment Interviews) and current mother–child interaction (Emotional Availability Scales) were examined with univariate correlation, moderator analyses, and structural equation models. We found relationships between attachment experiences and mother–child interaction, but RF had no moderating effect. Past loving experiences and perceived neglection, particularly with the own father in childhood, were predictors for the present mother–child interaction. There seems to be an intergenerational transmission of attachment experiences to the ongoing generation. Particularly past adverse childhood experiences with the own father seem to explain currently disruptive interactions with the child.Trial registration: DRKS00017008 and DRKS00016353.
Enhanced recovery after robotic ventral hernia repair: factors associated with overnight stay in hospital
Authors: Marckmann M. , Krarup P.-M. , Henriksen N. A. , Christoffersen M. W. , Jensen K. K. 
Published: September 2023

Abstract
Purpose
Enhanced recovery after surgery (ERAS) protocols lead to reduced post-operative stay and improved outcomes after most types of abdominal surgery. Little is known about the optimal post-operative protocol after robotic ventral hernia repair (RVHR), including the potential limits of outpatient surgery. We report the results of an ERAS protocol after RVHR aiming to identify factors associated with overnight stay in hospital, as well as patient-reported pain levels in the immediate post-operative period.

Methods
This was a prospective cohort study of consecutive patients undergoing RVHR. Patients were included in a prospective database, registering patient characteristics, operative details, pain and fatigue during the first 3 post-operative days and pre- and 30-day post-operative hernia-related quality of life, using the EuraHS questionnaire.

Results
A total of 109 patients were included, of which 66 (61%) underwent incisional hernia repair. The most performed procedure was TARUP (robotic transabdominal retromuscular umbilical prosthetic hernia repair) (60.6%) followed by bilateral roboTAR (robotic transversus abdominis release) (19.3%). The mean horizontal fascial defect was 4.8 cm, and the mean duration of surgery was 141 min. In total, 78 (71.6%) patients were discharged on the day of surgery, and factors associated with overnight stay were increasing fascial defect area, longer duration of surgery, and transverse abdominis release. There was no association between post-operative pain and overnight hospital stay. The mean EuraHS score decreased significantly from 38.4 to 6.4 (P < 0.001).

Conclusion
An ERAS protocol after RVHR was associated with a high rate of outpatient procedures with low patient-reported pain levels.
Porosity characterization using medical computed tomography scans of two deeply buried paleokarst aquifers in Silurian carbonates, southern Ontario, Canada
Authors: Carter Terry R. , Larmagnat Stéphanie , Sun Shuo , Letellier Philippe , Russell Hazen A.J. 
Published: September 2023

AbstractPaleokarst and paleokarst aquifers are not as well-documented as shallow karst, and studies of pores and pore networks are rare. Paleokarst lacks the open conduits typical of karst due to compaction, infilling, and diagenetic recrystallization by deep burial, so groundwater movement is through matrix porosity. In this case study, porosity networks in two saline aquifers in carbonate paleokarst of the Silurian Guelph Formation and Salina A-1 Carbonate Unit in southern Ontario (Canada) have been studied in drill cores at microscopic to macroscopic scales, utilizing medical computed tomography (CT) scans, optical petrography, macroscopic core examination, and scanning electron microscopy. The CT scans provided nondestructive three-dimensional visualization and quantification of pore distribution, size and volume, pore connections, and estimates of total porosity, similar to gas porosimetry. In the A-1 Carbonate, 50% of the pore volume comprises layers of macropores associated with algal laminations, with good horizontal connections. In the Guelph Formation, vuggy macropores contribute most of the pore volume. They are connected through subvertical fractures and rubble-filled karst conduits and by abundant small pores and micropores with poor horizontal connections. The Guelph paleokarst represents a longer period of subaerial exposure as evidenced by its greater thickness and geographic extent, former karst conduits, and near-total destruction of primary sedimentary fabrics. The findings provide real-world examples for construction of laboratory scale models of paleokarst aquifers, demonstrate the value of a multi-scale approach to porosity studies, and showcase the value of medical CT scans with its unique ability to visualize pore connections within drill cores.
Improving position encoding of transformers for multivariate time series classification
Authors: Foumani Navid Mohammadi , Tan Chang Wei , Webb Geoffrey I. , Salehi Mahsa 
Published: September 2023

AbstractTransformers have demonstrated outstanding performance in many applications of deep learning. When applied to time series data, transformers require effective position encoding to capture the ordering of the time series data. The efficacy of position encoding in time series analysis is not well-studied and remains controversial, e.g., whether it is better to inject absolute position encoding or relative position encoding, or a combination of them. In order to clarify this, we first review existing absolute and relative position encoding methods when applied in time series classification. We then proposed a new absolute position encoding method dedicated to time series data called time Absolute Position Encoding (tAPE). Our new method incorporates the series length and input embedding dimension in absolute position encoding. Additionally, we propose computationally Efficient implementation of Relative Position Encoding (eRPE) to improve generalisability for time series. We then propose a novel multivariate time series classification model combining tAPE/eRPE and convolution-based input encoding named ConvTran to improve the position and data embedding of time series data. The proposed absolute and relative position encoding methods are simple and efficient. They can be easily integrated into transformer blocks and used for downstream tasks such as forecasting, extrinsic regression, and anomaly detection. Extensive experiments on 32 multivariate time-series datasets show that our model is significantly more accurate than state-of-the-art convolution and transformer-based models. Code and models are open-sourced at https://github.com/Navidfoumani/ConvTran.
Z-Time: efficient and effective interpretable multivariate time series classification
Authors: Lee Zed , Lindgren Tony , Papapetrou Panagiotis 
Published: September 2023

AbstractMultivariate time series classification has become popular due to its prevalence in many real-world applications. However, most state-of-the-art focuses on improving classification performance, with the best-performing models typically opaque. Interpretable multivariate time series classifiers have been recently introduced, but none can maintain sufficient levels of efficiency and effectiveness together with interpretability. We introduce , a novel algorithm for effective and efficient interpretable multivariate time series classification. employs temporal abstraction and temporal relations of event intervals to create interpretable features across multiple time series dimensions. In our experimental evaluation on the UEA multivariate time series datasets, achieves comparable effectiveness to state-of-the-art non-interpretable multivariate classifiers while being faster than all interpretable multivariate classifiers. We also demonstrate that is more robust to missing values and inter-dimensional orders, compared to its interpretable competitors.