bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltage stability assessment of grid connected PV systems with FACTS devices
Authors: Abdullah Melat K. , Hassan Lokman H. , Moghavvemi M. 
Published: December 2022

AbstractThree static techniques (i.e. Power flow, Continuation Power Flow (CPF) and the Q–V curve) are used to assess the voltage stability of the power grid with a Solar Photovoltaic Generator (SPVG) and FACTS devices under nominal and heavy loading conditions. A static model is proposed for the power system that includes conventional power generation units and SPVGs with FACTS devices. Two models of SPVG were used (i.e., PV-model and PQ-model) to elucidate the effect of the SPVGs on the stability of the voltage under various operating conditions. The best location for FACTS devices was obtained under nominal and heavy load conditions using static techniques. A comparison between series and shunt FACTS devices under nominal and heavy loading conditions was carried out using the three static techniques. The interaction between SPVGs and FACTS devices was detailed in this paper. The proposed approach was tested on the New England 39-bus standard test system, and the results confirmed the effectiveness of the proposed approach under various operating conditions.
Measurement of temporal and spatial parameters of ice hockey skating using a wearable system
Authors: Khandan Aminreza , Fathian Ramin , Carey Jason P. , Rouhani Hossein 
Published: December 2022

AbstractIce hockey is a dynamic and competitive sport that requires a high level of neuromuscular and cardiovascular function. An objective assessment of skating helps coaches monitor athletes' performance during training sessions and matches. This study aimed to estimate the temporal and spatial parameters of skating by proposing an optimized configuration of wearable inertial measurement units (IMUs) and validating the system compared to in-lab reference systems. Ten participants were recruited to skate on a 14 m synthetic ice surface built in a motion-capture lab. Eight original event detection methods and three more adopted from gait analysis studies were implemented to detect blades-off and skate-strikes. These temporal events were detected with high accuracy and precision using skate-mounted IMUs. Also, four novel stride length estimation methods were developed to correct the estimated skaters' position using IMUs' readouts. The stride time, contact time, stride length, and stride velocity were obtained with relative errors of 3 ± 3%, 4 ± 3%, 2 ± 6%, and 2 ± 8%, respectively. This study showed that the wearable IMUs placed on skates and pelvis enables the estimation of temporal and spatial parameters of skating with high accuracy and precision, which could help coaches monitor skaters' performance in training.
Prevalence of colonization with multidrug-resistant bacteria in communities and hospitals in Kenya
Authors: Ita Teresa , Luvsansharav Ulzii-Orshikh , Smith Rachel M. , Mugoh Robert , Ayodo Charchil , Oduor Beatrice , Jepleting Moureen , Oguta Walter , Ouma Caroline , Juma Jane , Bigogo Godfrey , Kariuki Samuel , Ramay Brooke M. , Caudell Mark , Onyango Clayton , Ndegwa Linus , Verani Jennifer R. , Bollinger Susan , Sharma Aditya , Palmer Guy H. , Call Douglas R. , Omulo Sylvia 
Published: December 2022

AbstractWe estimated the prevalence of extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE), carbapenem-resistant Enterobacterales (CRE), and methicillin-resistant Staphylococcus aureus (MRSA) in communities and hospitals in Kenya to identify human colonization with multidrug-resistant bacteria. Nasal and fecal specimen were collected from inpatients and community residents in Nairobi (urban) and Siaya (rural) counties. Swabs were plated on chromogenic agar to presumptively identify ESCrE, CRE and MRSA isolates. Confirmatory identification and antibiotic susceptibility testing were done using the VITEK®2 instrument. A total of 1999 community residents and 1023 inpatients were enrolled between January 2019 and March 2020. ESCrE colonization was higher in urban than rural communities (52 vs. 45%; P = 0.013) and in urban than rural hospitals (70 vs. 63%; P = 0.032). Overall, ESCrE colonization was ~ 18% higher in hospitals than in corresponding communities. CRE colonization was higher in hospital than community settings (rural: 7 vs. 1%; urban: 17 vs. 1%; with non-overlapping 95% confidence intervals), while MRSA was rarely detected (≤ 3% overall). Human colonization with ESCrE and CRE was common, particularly in hospitals and urban settings. MRSA colonization was uncommon. Evaluation of risk factors and genetic mechanisms of resistance can guide prevention and control efforts tailored to different environments.
Genomic analysis of hypoxia inducible factor alpha in ray-finned fishes reveals missing Ohnologs and evidence of widespread positive selection
Authors: Townley Ian K. , Babin Courtney H. , Murphy Taylor E. , Summa Christopher M. , Rees Bernard B. 
Published: December 2022

AbstractAs aquatic hypoxia worsens on a global scale, fishes will become increasingly challenged by low oxygen, and understanding the molecular basis of their response to hypoxia may help to better define the capacity of fishes to cope with this challenge. The hypoxia inducible factor (HIF) plays a critical role in the molecular response to hypoxia by activating the transcription of genes that serve to improve oxygen delivery to the tissues or enhance the capacity of tissues to function at low oxygen. The current study examines the molecular evolution of genes encoding the oxygen-dependent HIFα subunit (HIFA) in the ray-finned fishes (Actinopterygii). Genomic analyses demonstrate that several lineages retain four paralogs ofHIFApredicted from two rounds of genome duplication at the base of vertebrate evolution, broaden the known distribution of teleost-specificHIFAparalogs, and provide evidence for salmonid-specificHIFAduplicates. Evolution of theHIFAgene family is characterized by widespread episodic positive selection at amino acid sites that potentially mediate protein stability, protein–protein interactions, and transcriptional regulation.HIFAtranscript abundance depends upon paralog, tissue, and fish lineage. A phylogenetically-informed gene nomenclature is proposed along with avenues for future research on this critical family of transcription factors.
In vivo micro-computed tomography imaging in liver tumor study of mice using Fenestra VC and Fenestra HDVC
Authors: Tan Ming Jia , Fernandes Nazarine , Williams Karla Chinnery , Ford Nancy Lee 
Published: December 2022

AbstractContrast agents are used to enhance the visibility of rodent organs during in vivo micro-computed tomography imaging. Specifically, this non-invasive technique can study liver tumor growth and progression in small animals. Fenestra VC and the novel Fenestra HDVC were compared for enhancement in the liver of healthy and tumor-bearing mice, and the images were compared for their ability to define the tumor border, volume and quantity of tumors. Fenestra VC and Fenestra HDVC were injected into healthy eight-week-old female mice (C57BL/6) via the tail vein then imaged at seven different time points. The experimental results showed that 0.005 mL/g of Fenestra HDVC resulted in the same enhancement for all eight organs as 0.01 mL/g of Fenestra VC across all time points. For the tumor study, B16F10 tumors were surgically introduced into ten eight-week-old female mice (C57BL/6) then imaged in vivo over a 3 day period. Ex vivo micro-CT images of the excised livers were also obtained. The tumor volume and quantity were measured in each image, and the tumour progression observed over 3 days. We showed Fenestra HDVC is effective for in vivo imaging in rodents because the optimal enhancement level in organs is maintained at a reduced injection volume.
Relationship between institutional intensive care volume prior to the COVID-19 pandemic and in-hospital death in ventilated patients with severe COVID-19
Authors: Amagasa Shunsuke , Kashiura Masahiro , Yasuda Hideto , Hayakawa Mineji , Yamakawa Kazuma , Endo Akira , Ogura Takayuki , Hirayama Atsushi , Yasunaga Hideo , Tagami Takashi 
Published: December 2022

AbstractWe aimed to evaluate the association between ICU patient volume before the COVID-19 pandemic and the outcomes of ventilated COVID-19 patients. We analyzed ventilated patients with COVID-19 aged > 17 years and enrolled in the J-RECOVER study, a retrospective multicenter observational study conducted in Japan between January and September 2020. Based on the number of patients admitted to the ICU between January and December 2019, the top third institutions were defined as high-volume centers, the middle third ones as middle-volume centers, and the bottom third ones as low-volume centers. The primary outcome measure was in-hospital mortality. Multivariate logistic regression analysis for in-hospital mortality and ICU patient volume was performed after adjusting for multiple propensity scores. Among 461 patients, 158, 158, and 145 patients were admitted to low-volume (20 institutions), middle-volume (14 institutions), and high-volume (13 institutions) centers, respectively. Admission to middle- and high-volume centers was not significantly associated with in-hospital death compared with admission to low-volume centers (adjusted odds ratio, 1.11 [95% confidence interval (CI): 0.55–2.25] and adjusted odds ratio, 0.81 [95% CI: 0.31–1.94], respectively). In conclusion, institutional intensive care patient volume prior to the COVID-19 pandemic was not significantly associated with in-hospital death in ventilated COVID-19 patients.
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
Authors: Sudevan Sachithra Thazhathuveedu , Oh Jong Min , Abdelgawad Mohamed A. , Abourehab Mohammed A. S. , Rangarajan T. M. , Kumar Sunil , Ahmad Iqrar , Patel Harun , Kim Hoon , Mathew Bijo 
Published: December 2022

AbstractThe inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO-B isoform more potently than hMAO-A. Furthermore, the majority of the molecules showed strong inhibitory actions against hMAO-B at 10 μM level with residual activities of less than 50%. Compound B10 has an IC50 value of 0.067 μM, making it the most potent inhibitor of hMAO-B, trailed by compound B15 (IC50 = 0.12 μM). The thiophene substituent (B10) in the A-ring exhibited the strongest hMAO-B inhibition structurally, however, increased residue synthesis did not result in a rise in hMAO-B inhibition. In contrast, the benzyl group at the para position of the B-ring displayed more hMAO-B inhibition than the other positions. Compounds B10 and B15 had relatively high selectivity index (SI) values for hMAO-B (504.791 and 287.600, respectively). Ki values of B10 and B15 were 0.030 ± 0.001 and 0.033 ± 0.001 μM, respectively. The reversibility study showed that B10 and B15 were reversible inhibitors of hMAO-B. PAMPA assay manifested that the benzyloxy chalcones (B10 and B15) had a significant permeability and CNS bioavailability with Pe value higher than 4.0 × 10–6 cm/s. Both compounds were stabilized in protein–ligand complexes by the π-π stacking, which enabled them to bind to the hMAO-B enzyme's active site incredibly effectively. The hMAO-B was stabilized by B10- and B15-hMAO-B complexes, with binding energies of − 74.57 and − 87.72 kcal/mol, respectively. Using a genetic algorithm and multiple linear regression, the QSAR model was created. Based on the best 2D and 3D descriptor-based QSAR model, the following statistics were displayed: R2 = 0.9125, Q2loo = 0.8347. These findings imply that B10 and B15 are effective, selective, and reversible hMAO-B inhibitors.
Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients
Authors: Jimenez-Marin Antonio , De Bruyn Nele , Gooijers Jolien , Llera Alberto , Meyer Sarah , Alaerts Kaat , Verheyden Geert , Swinnen Stephan P. , Cortes Jesus M. 
Published: December 2022

AbstractBeyond the characteristics of a brain lesion, such as its etiology, size or location, lesion network mapping (LNM) has shown that similar symptoms after a lesion reflects similar dis-connectivity patterns, thereby linking symptoms to brain networks. Here, we extend LNM by using a multimodal strategy, combining functional and structural networks from 1000 healthy participants in the Human Connectome Project. We apply multimodal LNM to a cohort of 54 stroke patients with the aim of predicting sensorimotor behavior, as assessed through a combination of motor and sensory tests. Results are two-fold. First, multimodal LNM reveals that the functional modality contributes more than the structural one in the prediction of sensorimotor behavior. Second, when looking at each modality individually, the performance of the structural networks strongly depended on whether sensorimotor performance was corrected for lesion size, thereby eliminating the effect that larger lesions generally produce more severe sensorimotor impairment. In contrast, functional networks provided similar performance regardless of whether or not the effect of lesion size was removed. Overall, these results support the extension of LNM to its multimodal form, highlighting the synergistic and additive nature of different types of network modalities, and their corresponding influence on behavioral performance after brain injury.
Artificial temperature-compensated biological clock using temperature-sensitive Belousov–Zhabotinsky gels
Authors: Yamada Yuhei , Ito Hiroshi , Maeda Shingo 
Published: December 2022

AbstractThe circadian rhythm is a fundamental physiological function for a wide range of organisms. The molecular machinery for generating rhythms has been elucidated over the last few decades. Nevertheless, the mechanism for temperature compensation of the oscillation period, which is a prominent property of the circadian rhythm, is still controversial. In this study, we propose a new mechanism through a chemically synthetic approach (i.e., we realized temperature compensation by the Belousov–Zhabotinsky (BZ) gels). The BZ gels are prepared by embedding a metal catalyst of the BZ reaction into the gel polymer. We made the body of BZ gels using a temperature-sensitive polymer gel, which enabled temperature compensation of the oscillation by using temperature dependence of volume. Moreover, we constructed a simple mathematical model for the BZ oscillation in temperature-sensitive gels. The model can reproduce temperature compensation of BZ gels, even though all reactions are temperature sensitive according to the Arrhenius rule. Our finding hints that a soft body coupling may be underlying temperature-compensated biological functions, including circadian rhythms.
Mechanical and gas adsorption properties of graphene and graphynes under biaxial strain
Authors: de Oliveira Raphael B. , Borges Daiane Damasceno , Machado Leonardo D. 
Published: December 2022

AbstractThe exceptional properties of two-dimensional (2D) solids have motivated extensive research, which revealed the possibility of controlling many characteristics of these materials through strain. For instance, previous investigations demonstrated that compressive deformation could be used to direct the chemisorption of atomic hydrogen and oxygen. Still, to our knowledge, there is no work detailing how strain affects the adsorption isotherms of 2D materials and the adsorption properties of materials such as the graphynes, which are monolayers composed of sp and sp$$^2$$

2

carbon atoms. In the present work, we analyze how biaxial tensile deformation changes the adsorption properties of four 2D materials (graphene, $$\alpha $$
α
-graphyne, $$\beta $$
β
-graphyne, and $$\gamma $$
γ
-graphyne). To achieve this, we perform Monte Carlo Grand Canonical calculations to obtain the adsorption isotherms of H$$_2$$

2

, CO$$_2$$

2

, and CH$$_4$$

4

on the monolayers with and without strain. And, to apply the deformation, we carry out Molecular Dynamics simulations. We find a substantial reduction in the amount of gas adsorbed on the monolayers for nearly all gas–solid combinations. This is particularly true for graphene, where 14.5% strain reduces the quantity of H$$_2$$

2

/CO$$_2$$

2

/CH$$_4$$

4

by 44.7/64.1/41.7% at P $$=$$
=
1 atm. To understand the results, we calculate adsorption enthalpies and analyze the gas distribution above the monolayers. We also characterize the mechanical properties of the considered solids under biaxial deformation. Finally, a comparison of pore sizes with the kinetic diameters of various gases suggests applications for the graphynes, with and without strain, in gas separation.
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells
Authors: Criscione Steven W. , Martin Matthew J. , Oien Derek B. , Gorthi Aparna , Miragaia Ricardo J. , Zhang Jingwen , Chen Huawei , Karl Daniel L. , Mendler Kerrin , Markovets Aleksandra , Gagrica Sladjana , Delpuech Oona , Dry Jonathan R. , Grondine Michael , Hattersley Maureen M. , Urosevic Jelena , Floc’h Nicolas , Drew Lisa , Yao Yi , Smith Paul D. 
Published: December 2022

AbstractThird-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, an irreversible EGFR-TKI, are important treatments for non-small cell lung cancer with EGFR-TKI sensitizing or EGFR T790M resistance mutations. While patients treated with osimertinib show clinical benefit, disease progression and drug resistance are common. Emergence of de novo acquired resistance from a drug tolerant persister (DTP) cell population is one mechanism proposed to explain progression on osimertinib and other targeted cancer therapies. Here we profiled osimertinib DTPs using RNA-seq and ATAC-seq to characterize the features of these cells and performed drug screens to identify therapeutic vulnerabilities. We identified several vulnerabilities in osimertinib DTPs that were common across models, including sensitivity to MEK, AURKB, BRD4, and TEAD inhibition. We linked several of these vulnerabilities to gene regulatory changes, for example, TEAD vulnerability was consistent with evidence of Hippo pathway turning off in osimertinib DTPs. Last, we used genetic approaches using siRNA knockdown or CRISPR knockout to validate AURKB, BRD4, and TEAD as the direct targets responsible for the vulnerabilities observed in the drug screen.
The industry impact of the American Medical Association’s Digital Medicine Payment Advisory Group (DMPAG)
Authors: Kvedar Joseph C. , Mittermaier Mirja , Pritzker Jordan 
Published: December 2022

AbstractDigital medicine interventions are currently transforming health care and have created new efficiencies in the delivery process. The business model along with physician payment models are crucial drivers for the adoption of innovations. In the U.S., physician payment is mostly codified in the Current Procedural Terminology (CPT). Until recently, CPT codes related to digital medicine activities were mainly limited to telephone services. To embrace the evolving implementation of the various modalities of digital medicine, the American Medical Association (AMA) determined that a more comprehensive codeset is needed. Thus, the Digital Medicine Payment Advisory Group (DMPAG) was initiated in late 2016. Since then, the DMPAG has achieved a significant and measurable impact on digital medicine intervention adoption by introducing CPT codes for remote physiologic monitoring, remote therapeutic monitoring, artificial intelligence, and other digital innovations.
Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC
Authors: Devi-Marulkar Priyanka , Fastenackels Solène , Karapentiantz Pierre , Goc Jérémy , Germain Claire , Kaplon Hélène , Knockaert Samantha , Olive Daniel , Panouillot Marylou , Validire Pierre , Damotte Diane , Alifano Marco , Murris Juliette , Katsahian Sandrine , Lawand Myriam , Dieu-Nosjean Marie-Caroline 
Published: December 2022

AbstractOn one hand, regulatory T cells (Tregs) play an immunosuppressive activity in most solid tumors but not all. On the other hand, the organization of tumor-infiltrating immune cells into tertiary lymphoid structures (TLS) is associated with long-term survival in most cancers. Here, we investigated the role of Tregs in the context of Non-Small Cell Lung Cancer (NSCLC)-associated TLS. We observed that Tregs show a similar immune profile in TLS and non-TLS areas. Autologous tumor-infiltrating Tregs inhibit the proliferation and cytokine secretion of CD4+ conventional T cells, a capacity which is recovered by antibodies against Cytotoxic T-Lymphocyte-Associated protein-4 (CTLA-4) and Glucocorticoid-Induced TNFR-Related protein (GITR) but not against other immune checkpoint (ICP) molecules. Tregs in the whole tumor, including in TLS, are associated with a poor outcome of NSCLC patients, and combination with TLS-dendritic cells (DCs) and CD8+ T cells allows higher overall survival discrimination. Thus, Targeting Tregs especially in TLS may represent a major challenge in order to boost anti-tumor immune responses initiated in TLS.
Optimal finite alphabet scheme for NOMA uplink channels
Authors: Zhen Jina , Wong Anzhong , Wong Kon Max , Yang Shouyi , Zhang Jiankang 
Published: December 2022

AbstractThe design of an optimal non‐orthogonal multiple access (NOMA) transmission scheme with finite alphabet inputs for a typical two‐user uplink wireless communication system is investigated in which each terminal is equipped with a single antenna. Each of the two users utilises a four quadrature amplitude modulation (4‐QAM) constellation to transmit information data to a common base station, and the receiver employs a maximum likelihood (ML) detector to jointly estimate both transmitted signals. Assuming the availability of channel state information at both the transmitters and the receiver, it is aimed to design a pair of scalar beamformers for the two users such that the minimum Euclidean distance between elements of the received sum‐constellation is maximised subject to the power constraints on the users. A thorough consideration of all the different conditions results in the derivation of a closed‐form optimal beamformer design. As well, examination of the construction of sum‐constellation resulted from the optimum design directly leads to the unique decoding of the original transmitted signal of each user. To facilitate practical implementation, a fast decoding procedure of the optimum NOMA scheme is further developed. The corresponding theoretic probability of ML detection error is also derived. The theoretical development of an optimum sum‐constellation for the basic 2‐user 4‐QAM system provides a solid platform for the derivation of an optimum sum‐constellation for a K‐user and/or M‐QAM system. Indeed, a simple development of the basic sum‐constellation map facilitates such extensions. Numerical simulations not only demonstrate that the performance of the fast decoder agrees closely with the theoretical analysis, but also verify that it is superior in performance to other existing NOMA designs for the same system under high signal‐to‐noise ratio.