bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Evaluation of Multiple Sclerosis–Related Fatigue with a Special Focus on Fatigability
Authors: ROYER NICOLAS , BROWNSTEIN CALLUM G. , KENNOUCHE DJAHID , ESPEIT LOIC , TESTON ANTHONY , BOUTET CLAIRE , FÉASSON LÉONARD , CAMDESSANCHÉ JEAN-PHILIPPE , MILLET GUILLAUME Y. 
Published: June 2023

ABSTRACT

Introduction
Fatigue is the most common and disabling symptom in multiple sclerosis (MS), being reported by 55% to 78% of patients with MS (PwMS). Etiology of MS-related fatigue remains poorly understood, but an increased neuromuscular fatigability (i.e., greater loss of torque during exercise) could contribute to this phenomenon. This study aimed to characterize the correlates of MS-related fatigue in PwMS using a comprehensive group of physiological and psychosocial measures, with a particular focus on fatigability.

Methods
Forty-two relapsing–remitting PwMS and 20 healthy subjects were recruited. PwMS were assigned in two groups (high (HF) and low (LF) fatigue) based on two fatigue questionnaires (Fatigue Severity Scale and Modified Fatigue Impact Scale). The main outcomes of this study are derived from incremental cycling completed to task failure (i.e., inability to pedal around 60 rpm). Maximal voluntary contraction (MVC), rating of perceived exertion, and central and peripheral parameters measured using transcranial magnetic and peripheral nerve stimulation were assessed in the knee extensor muscles before, during, and after the fatiguing task. Other potential correlates of fatigue were also tested.

Results
MVC torque decreased to a greater extent for the HF group than LF group after the third common stage of the incremental fatiguing exercise (−15.7% ± 6.6% vs −5.9% ± 13.0%, P < 0.05), and this occurred concurrently with a higher rating of perceived exertion for HF (11.8 ± 2.5 vs 9.3 ± 2.6, P < 0.05). Subjective parameters (depression, quality of life) were worse for HF compared with LF and healthy subjects (P < 0.001). Moreover, MVC torque loss at the final common stage and maximal heart rate explained 29% of the variance of the Modified Fatigue Impact Scale.

Conclusions
These results provide novel insight into the relationship between MS-related fatigue and fatigability among PwMS. The HF group exhibited greater performance fatigability, likely contributing to a higher perceived exertion than the LF group when measured during a dynamic task.
Prediction of Hematoma Expansion in Hypertensive Intracerebral Hemorrhage by a Radiomics Nomogram
Authors: Dai Jialing , Liu Dan , Li Xia , Liu Yuyao , Wang Fang , Yang Quan 
Published: June 2023

Objective: To develop and validate a radiomics-based nomogram model which aimed to predict hematoma expansion (HE) in hypertensive intracerebral hemorrhage (HICH).
Methods: Patients with HICH (n=187) were included from October 2017 to March 2022 in the Yongchuan Affiliated Hospital of Chongqing Medical University. Patients were randomly divided into a training set (n=130) and a validation set (n=57) in a ratio of 7:3. The radiomic features were extracted from the regions of interest (including main hematoma, the surrounding small hematoma(s) and perihematomal edema) in the first CT scan images. The variance threshold, SelectKBest and LASSO (least absolute shrinkage and selection operator), features were selected and the radiomics signature was built. Multivariate logistic regression was used to establish a nomogram based on clinical risk factors and the Rad-score. A receiver operating characteristic (ROC) curve was used to evaluate the generalization of the models’ performance.The calibration curve and the Hosmer-Lemeshow test were used to assess the calibration of the predictive nomogram. And decision curve analysis (DCA) was used to evaluate the prediction model.
Results: Thirteen radiomics features were selected to construct the radiomics signature, which has a robust association with HE. The radiomics model found that blend sign was a predictive factor of HE. The radiomics model ROC in the training set was 0.89 (95%CI 0.82-0.96) and was 0.82 (95%CI 0.60-0.93) in the validation set. The nomogram model was built using the combined prediction model based on radiomics and blend sign, and worked well in both the training set (ROC: 0.90[95%CI 0.83-0.96]) and the validation set (ROC: 0.88[95%CI 0.71-0.93]).
Conclusion: The radiomic signature based on CT of HICH has high accuracy for predicting HE. The combined prediction model of radiomics and blend sign improves the prediction performance.
doi: https://doi.org/10.12669/pjms.39.4.7724
How to cite this: Dai J, Liu D, Li X, Liu Y, Wang F, Yang Q. Prediction of Hematoma Expansion in Hypertensive Intracerebral Hemorrhage by a Radiomics Nomogram. Pak J Med Sci. 2023;39(4):1149-1155. doi: https://doi.org/10.12669/pjms.39.4.7724
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The role of oncogenes and tumor suppressor genes in determining survival rates of lung cancer patients in the population of North Sumatra, Indonesia
Authors: Soeroso Noni Novisari , Ananda Fannie Rizki , Sitanggang Johan Samuel , Vinolina Noverita Sprinse 
Published: June 2023

Background: Gaining a better understanding of molecular alterations in the pathogenesis of lung cancer reveals a significant change in approach to the management and prognosis of lung cancer. Several oncogenes and tumor suppressor genes have been identified and have different roles related to survival rates in lung cancer patients. This study aims to determine the role of KRAS, EGFR, and TP53 mutations in the survival rate of lung cancer patients in the population of North Sumatra. Methods: This is a retrospective cohort study involving 108 subjects diagnosed with lung cancer from histopathology specimens. DNA extractions were performed using FFPE followed by PCR examinations for assessing the expressions of EGFR, RAS, and TP53 protein. Sequencing analysis was carried out to determine the mutations of EGFR exon 19 and 21, RAS protein exon 2, and TP53 exon 5-6 and 8-9. Data input and analysis were conducted using statistical analysis software for Windows. The survival rate analysis was presented with Kaplan Meier. Results: 52 subjects completed all procedures in this study. Most of the subjects are male (75%), above 60 years old (53.8%), heavy smokers (75%), and suffer from adenocarcinoma type of lung cancer (69.2%). No subjects showed KRAS exon 2 mutations. Overall survival rates increased in patients with EGFR mutations (15 months compared to 8 months; p=0.001) and decreased in patients with TP53 mutations (7 months compared to 9 months; p=0.148). Also, there was increasing Progression-Free Survival in patients with EGFR mutations (6 months compared to 3 months) (p=0.19) and decreasing PFS in patients with TP53 mutations (3 months compared to 6 months) (p=0.07). Conclusions: There were no KRAS mutations in this study. EGFR mutations showed a higher survival rate, while TP53 mutations showed a lower survival rate in overall survival and progression-free survival.
Anti-inflammatory effects of oral cannabidiol in rat models
Authors: Bunman Sitthiphon , Muengtaweepongsa Sombat , Piyayotai Dilok , Charlermroj Ratthaphol , Kanjana Korawit , Kaew-amdee Sudtida , Makornwattana Manlika , Kim Sanghyun 
Published: June 2023

Background: Cannabidiol (CBD), a non-psychoactive compound in cannabis, has various pharmacological advantages associated with clinical use, especially for reducing inflammatory arthritis and paw edema in animal models. This study evaluated the anti-inflammatory effects of various oral CBD doses (5-40 mg/kg) in rats after injecting 0.1 mL of carrageenan. Methods: Rats were orally administered various CBD doses an hour before the carrageenan-induced inflammation to observe the anti-inflammatory effects of CBD. Paw edema was measured at 0, 1, 2, 3, 4, and 5 h after carrageenan induction. Following a six-hour induction of carrageenan, histological analysis employing hematoxylin and eosin staining was performed to investigate inflammatory cell infiltration at paw edema. In addition, blood samples were taken and used for cytokine detection using ELISA and bead-base assays. Results: We found that the efficacy of all oral CBD doses decreased paw edema and was comparable to or had greater efficacy than an anti-inflammatory agent (Diclofenac 10 mg/kg), especially at 2, 3, 4, and 5 h after induced paw edema. Moreover, a high dose (40 mg/kg) of CBD suppressed chemokine productions, including monocyte chemoattractant protein (MCP)-1 and MCP-3, compared to diclofenac and placebo. In addition, serotonin levels, a pro-inflammatory-like neurotransmitter, were drastically decreased in rats treated with either CBD or diclofenac. Conclusions: Oral CBD is an interesting anti-inflammatory agent for use in the clinical setting. However, more information regarding drug safety and efficacy in a large population of human studies is needed.
Psychometric properties of portable devices used in kinematic gait assessment after stroke: a systematic review protocol
Authors: Silva Raiff , Silva Stephano , Santos Vitor , Fernandes Jefferson , Oliveira Raul , Ribeiro Karyna , Fernandes Aline , Ribeiro Tatiana 
Published: June 2023

Background: Kinematic gait assessment is essential to the gait rehabilitation program after stroke. Portable devices composed of inertial sensors are an alternative for this evaluation. However, knowledge regarding the psychometric properties of these devices is needed to understand their accuracy, especially in evaluation of individuals with movement disorders (e.g., people post stroke). This systematic review aims to analyze the psychometric properties of portable devices that use inertial sensors to assess kinematic gait parameters in people post stroke. We will also investigate which portable device assesses alterations in lower limb angular movements during gait. Methods: We will search for studies in English without publication date restriction, that evaluated psychometric properties of portable devices that use inertial sensors to assess kinematic gait parameters in people after stroke. Searches will be performed in the following electronic databases: Cochrane Central Registry of Controlled Trials (CENTRAL), Medline/PubMed, EMBASE Ovid, CINAHL EBSCO, PsycINFO Ovid, IEEE Xplore Digital Library (IEEE), and Physiotherapy Evidence Database (PEDro). Gray literature will also be searched, including published and unpublished studies (dissertations and theses). The Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) risk of bias tool will be used to assess the quality of studies that analyzed reliability and measurement error of devices. Expected results: This will be the first review assessing the risk of bias in studies that analyzed psychometric properties of portable devices that use inertial sensors to assess kinematic gait parameters in people post stroke. Then, we hope to elucidate this topic and help the decision-making of clinicians regarding the feasibility of these devices. Finally, we also hope to provide an overview of the characteristics of portable devices that assessed changes in angular lower limb movements during gait in this population. Registration: The protocol was registered in Open Science Framework on May 11th 2023 (https://doi.org/10.17605/OSF.IO/7M6DA).
Usage and Impact of Teachers Self-Assessment Practices on Teaching of Upper Basic Social Studies in Kwara State
Authors: Nasiru Olokooba Isaa , Uyanne Elizabeth Obiageli 
Published: June 2023

Background: Self-assessment is a mechanism that enables teachers to reflect how their own work meets the goals. It is set for teaching concepts and enhancing effective teaching and learning. The objectives of this study are to investigate prevalent patterns of self-assessment practices, extent of using as well as the impacts of self-assessment practices on teaching Social Studies.
Contribution: This study investigates impact of teachers’ self-assessment practices on teaching of upper basic Social Studies.
Method: Through simple random sampling technique, 600 upper basic Social Studies teachers were selected. A questionnaire is used for data collection. Percentage and mean ranking were used to analyze the collected data.
Results: The findings of the study show that peer observation, testing the flexibility of teaching style and activity reports are prevalent patterns of self-assessment practices and frequently used. The practices have impacts on teaching of upper basic Social Studies in schools.
Conclusion: it is recommended that teachers should constantly self-assess their teaching processes to recognize and improve on the progress teaching in the classrooms.
Implementation of Online Marketing Strategies in Apen Grocery Shops as A Solution to Facing Competition and The Covid-19 Pandemic Crisis
Authors: Himawati Ditiya , Nurcahyo Bagus , Saputri Ika Puji , Revena Ravena 
Published: June 2023

Background: Marketplace make it very easy for customers to meet their needs besides that, it is also a means for SMEs to be able to survive facing competition and the Covid 19 pandemic crisis, so this is one of the challenges for sellers who sell offline. An example of offline sales is traditional market traders. This community service (public servant) was carried out at one of the basic food shops located in traditional markets, namely Apen Groceries. Apen Groceries Storeis a shop that provides staple goods located in Pasar Kebayoran Lama, South Jakarta. Apen Groceries Storeis a shop that is in a traditional market, so Apen Groceries Storehas challenges that must be faced, including competitors in modern markets (supermarkets) and online sales, as well as the Covid 19 pandemic situation which is still ongoing today where these conditions are very limiting space for the conventional Apen Shop business.
Contribution: This public servant activity contributes to small and medium businesses, in this case the Apen Grocery Store.
Method: Implementing online marketing strategies using social media applications and e-marketplaces (such as whatsapp, Instagram and the Shopee application).
Results: The results obtained include sales forecasting, namely being able to estimate whether the number of customers will be sufficient with the existing stock or even less, so that they can monitor the product.
Conclusion: Grocery stores can already sell their products with offline and online access, namely with the help of social media and e-marketplaces
Empowerment of Robusta Coffee Farmers to Develop Entrepreneurs in Aceh Barat Based on Technology Application
Authors: Aulia Muhammad Reza , Darmansyah Dedy , Nugroho Yoga , Safrika Safrika , Nasution Anisah , Tanjung Yulia Windi 
Published: June 2023

Background: The problems of robusta coffee farmer in Aceh Barat Regency are lack of insight into the downstream potential of robusta coffee, lack of business development ideas and farmer do not understand making financial reports, legality and business organizational systems. For this reason, assistance are needed to coffee farmers so that they develop their business and increase their income.
Contribution: Increasing insight into potential utilization and marketing, entrepreneurial development ideas, business finance.
Method: Community service was held on 11-13 November 2022 at Teuku Umar University. The approach taken is in the form of a process of education, training and mentoring focuses on three stages: (1) Education of potential beneficiaries and development of the Robusta coffee business (2) Assistance in preparing financial reports, business organization systems and technology adoption and (3) Socialization of efficient coffee marketing channels.
Results: The process that goes through each stage is the purchase of red cherries for robusta coffee. There are 3 sub-districts that currently can become suppliers of robusta coffee in Aceh Barat Regency, namely Woyla Induk District, Samatiga District and Meureubo District. The three districts have taken samples and carried out the drying process to become green beans. After purchasing the fruit, the next stage is the process of drying, roasting, grinding and packaging.
Conclusion: The participants who were accompanied were able to apply coffee powder packaging technology at IBT, understand the legality of the robusta coffee business, understand the marketing of the robusta coffee business
A study on the adoption intention of cold chain prepared Dishes based on consumer orientation mentality
Authors: Luo Feng , Shang Wei , Gan Junwei 
Published: June 2023

Background: Cold chain prepared dishes, as a new type of food with low temperature and dual attributes, have attracted more and more attention from consumers. From the perspective of consumers' brand positioning mentality, this study integrated the brand, quality and other attributes of cold chain prepared vegetables, and studied the positioning mentality and adoption behavior of Chinese consumers In this study, three cold-chain prefabricated dishes, "pickled cabbage fish", "tomato Braised beef brisket" and "Huangpi fishball", were selected as investigation objects.
Contribution: The contribution of this study is that different food value attributes explain the law of consumers' willingness to adopt cold chain prepared dishes through brand positioning mentality, and find out how different degrees of vulnerability and quality warranty
Method: Based on ZMET survey method, product effect data were used to analyze and verify structural equation model.
Results: Different value evaluation directly affects consumers' brand positioning mentality, brand positioning mind as an intermediate variable has a significant correlation with adoption intention. The degree of vulnerability moderates the relationship between value evaluation and brand positioning mentality, and the degree of warranty period regulates the relationship between quality value, brand positioning mentality and adoption intention respectively.

Conclusion: It also provides new marketing tools and theories for entrepreneurs and marketers in the cold chain food industry, which contributes to the promotion and diffusion of cold chain prepared food for consumers
Deliberating Marriage Payment through Jujuran within Banjarese Community
Authors: Hafidzi Anwar 
Published: June 2023

Abstract: In the Banjarese culture of marriage, besides dowry, jujuran is also paid by the man to the woman in a certain amount of money under the request of the women’s family. Many researchers have discussed dowry, but only a few have revealed the reality of jujuran as a sign of marriage. This study was conducted with a phenomenological approach as part of a qualitative approach. The study aims to understand and describe a phenomenon about the subjects’ experiences regarding the Banjar community's marriage system, South Kalimantan, Indonesia. The research argued that the Banjarese use jujuran as a sign of a marriage agreement. It also asserts that although jujuran aims to improve their children's economic standard when married, it reveals that this system determines who has the right to propose to their daughters. The paper also maintains that the local practice of jujuran payment has, to some extent, violated the rights of the women to their choice in marriage, mainly when the prospective grooms are unable to pay the jujuran. Abstrak: Dalam budaya perkawinan Banjar, selain mas kawin, jujuran juga dibayarkan oleh laki-laki kepada perempuan dalam jumlah tertentu atas permintaan keluarga perempuan. Banyak peneliti telah membahas tentang mahar, namun hanya sedikit yang mengungkap realitas jujuran sebagai tanda pernikahan. Penelitian ini dilakukan dengan pendekatan fenomenologi sebagai bagian dari pendekatan kualitatif. Penelitian ini bertujuan untuk memahami dan mendeskripsikan fenomena sistem perkawinan di masyarakat Banjar, Kalimantan Selatan, Indonesia. Hasil penelitian menunjukkan bahwa orang Banjar menggunakan jujuran sebagai tanda akad nikah. Hal ini juga menegaskan bahwa meski tujuan jujuran adalah untuk meningkatkan taraf ekonomi anak-anak mereka ketika mereka menikah, tetapi sistem ini dapat menentukan siapa yang berhak melamar anak perempuannya. Penelitian ini juga menyatakan bahwa praktik pembayaran jujuran setempat sampai batas tertentu telah melanggar hak perempuan atas pilihan mereka dalam pernikahan, terutama ketika calon pengantin pria tidak mampu membayar jujuran.
Local Values and Judges’ Legal Discretion in Islamic Court of Makassar: the Case of “Dispensasi Nikah”
Authors: Mustofa Kholifatun Nur 
Published: June 2023

Abstract: This paper examines the legal considerations used by judges in the case of marriage dispensation at the Makassar Religious Court. This paper focuses on two things, first, the judge's consideration in deciding the marriage dispensation case, while the second focus is on the age of youngest couple who applied for a marriage dispensation. The marriage dispensation decision at the Makassar Religious Court is used as the primary source, while the secondary sources are collected from interviews and scientific works related to the topic of this research. Legal pluralism is applied as an approach to determine which law is more dominant in granting marriage dispensation in Makassar. The results revealed that majority of judges use customary law as a legal consideration in granting marriage dispensation cases at the Court. The judge used customary law as a consideration to granting a marriage dispensation application. It is reported that the youngest age in the marriage dispensation was 13 years for women and 14 years for men. The author found that 13 of the 16 cases of marriage dispensation stated that the child of the applicant who filed the marriage dispensation case was not pregnant. Abstrak: Paper ini mengkaji tentang pertimbangan hukum yang digunakan oleh hakim dalam memutuskan perkara dispensasi nikah di Pengadilan Agama Makassar. Tulisan ini berfokus pada dua hal, pertama, pertimbangan yang digunakan hakim dalam memutuskan perkara dispensasi nikah. Kedua fokus pada berapa usia pasangan termuda yang mengajukan dispensasi nikah. Putusan dispensasi nikah di Pengadilan Agama Makassar penulis gunakan sebagai sumber primer, sedangkan sumber sekunder penulis dapatkan dari wawancara dan karya ilmiah yang berkaitan dengan topik penelitian ini. Pluralisme hukum diterapkan sebagai pendekatan untuk menentukan hukum mana yang lebih dominan dalam pemberian dispensasi perkawinanPengadilan Agama Makassar. Hasil penelitian menunjukkan bahwa mayoritas hakim menggunakan hukum adat sebagai pertimbangan hukum dalam mengabulkan perkara dispensasi nikah di Pengadilan. Hakim menggunakan hukum adat sebagai pertimbangan untuk mengabulkan permohonan dispensasi nikah. Penelitian ini mengungkapkan bahwa usia termuda dalam dispensasi perkawinan adalah 13 tahun untuk perempuan dan 14 tahun untuk laki-laki. Penulis menemukan bahwa 13 dari 16 kasus dispensasi nikah menyatakan bahwa anak pemohon yang mengajukan dispensasi nikah tidak hamil.