bluuebunny/crossref_metadata_2025_split huggingface dataset:
A machine learning approach for quantifying age-related histological changes in the mouse kidney
Authors: Sheehan Susan , Mawe Seamus , Chen Mandy , Klug Jenna , Ladiges Warren , Korstanje Ron , Mahoney J. Matthew 
Published: July 2023

ABSTRACTThe ability to quantify aging-related changes in histological samples is important, as it allows for evaluation of interventions intended to effect health span. We used a machine learning architecture that can be trained to detect and quantify these changes in the mouse kidney. Using additional held out data, we show validation of our model, correlation with scores given by pathologists using the Geropathology Research Network aging grading scheme, and its application in providing reproducible and quantifiable age scores for histological samples. Aging quantification also provides the insights into possible changes in image appearance that are independent of specific geropathology-specified lesions. Furthermore, we provide trained classifiers for H&E-stained slides, as well as tutorials on how to use these and how to create additional classifiers for other histological stains and tissues using our architecture.This architecture and combined resources allow for the high throughput quantification of mouse aging studies in general and specifically applicable to kidney tissues.
We see what we hear: dissonant music engages early visual processing
Authors: Bravo Fernando , Glogowski Jana , Stamatakis Emmanuel Andreas , Herfert Kristina 
Published: July 2023

AbstractThe neuroscientific examination of music processing in audiovisual contexts offers a valuable framework to assess how auditory information influences the emotional encoding of visual information. Using fMRI during naturalistic film viewing, we investigated the neural mechanisms underlying music’s effect on valence inferences during mental state attribution. Thirty-eight participants watched the same short-film accompanied by systematically controlled consonant or dissonant music. Subjects were instructed to think about the main character’s intentions. The results revealed that increasing levels of dissonance led to more negatively-valenced inferences, displaying the profound emotional impact of musical dissonance. Crucially, at the neuroscientific level and despite music being the sole manipulation, dissonance evoked the response of the primary visual cortex response (V1). Functional/effective connectivity analysis showed a stronger coupling between the auditory ventral stream (AVS) and V1 in response to tonal dissonance, and demonstrated the modulation of early visual processing via top-down feedback inputs from the AVS to V1. These V1 signal changes indicate the influence of high-level contextual representations associated with tonal dissonance on early visual cortices, serving to facilitate the emotional interpretation of visual information. The findings substantiate the critical role of audio-visual integration in shaping higher-order functions such as social cognition.Significance statementThe present study reveals responses in the primary visual cortex modulated by musical information: tonal dissonance recruits early visual processing via feedback interactions from the auditory ventral pathway to the primary visual cortex. We demonstrate that the auditory “what” ventral stream plays a role in assigning meaning to non-verbal sound cues, such as dissonant music conveying negative emotions, providing an interpretative framework that serves to process the audio-visual experience. Our results highlight the significance of employing systematically controlled music, which can isolate emotional valence from the arousal dimension, to elucidate the brain’s sound-to-meaning interface and its distributive crossmodal effects on early visual encoding during naturalistic film viewing.Data sharingAll relevant data are available from the figshare database DOI: 10.6084/m9.figshare.21345240
CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling
Authors: Giblin Sean P. , Ranawana Sashini , Hassibi Shyreen , Birchenough Holly L. , Mincham Kyle T. , Snelgrove Robert J. , Tsuchiya Tomoko , Kanegasaki Shiro , Dyer Douglas , Pease James E. 
Published: July 2023

AbstractCXCL17 is a mucosally secreted protein, and the most recently identified human chemokine, an assignment based on protein fold prediction and chemotactic activity for leukocytes. However, these credentials have been the subject of much recent discussion and no experimental evidence has been presented regarding the definitive structure of CXCL17. In this study, we evaluated the structural and chemoattractant credentials of CXCL17 to better characterise this molecule, and gain deeper insights into its functional role as a glycosaminoglycan (GAG) binding protein.In the absence of structural information,in silicomodelling techniques assessed the likelihood of CXCL17 adopting a chemokine-fold. Recombinant CXCL17 was synthesized in mammalian and prokaryotic systems. Modified Boyden chamber and real-time chemotaxis assays assessed the ability of CXCL17 to promote chemotaxis of murine splenocytes, human neutrophils and CXCR1-transfectants. The efficacy of CXCL17 binding to GAGs was quantified with solid-phase assays and bio-layer interferometry techniques.All modelling efforts failed to support classification of CXCL17 as a chemokine based on its predicted conformation. Recombinant CXCL17 was observed to dimerize as a function of concentration, a characteristic of several chemokines. Contrary to a previous report, CXCL17 was not chemotactic for murine splenocytes, although it was a low-potency chemoattractant for human neutrophils at micromolar concentrations, several orders of magnitude higher than those required for CXCL8. As anticipated due to its highly basic nature, CXCL17 bound to GAGs robustly, with key C-terminal motifs implicated in this process. While inactive via CXCR1, CXCL17 was found to inhibit CXCR1-mediated chemotaxis of transfectants to CXCL8 in a dose-dependent manner.In summary, despite finding little evidence for chemokine-like structure and function, CXCL17 readily bound GAGs, and could modulate chemotactic responses to another chemokinein vitro.We postulate that such modulation is a consequence of superior GAG-binding, and that C-terminal fragments of CXCL17 may serve as prototypic inhibitors of chemokine function.
Multisensory integration operates on correlated input from unimodal transients channels
Authors: Parise Cesare V. , Ernst Marc O. 
Published: July 2023

AbstractAudiovisual information reaches the brain via both sustained and transient input channels, representing signals’ intensity over time or changes thereof, respectively. To date, it is unclear to what extent transient and sustained input channels contribute to the combined percept obtained through multisensory integration. Based on the results of two novel psychophysical experiments, here we demonstrate the importance of the transient (instead of the sustained) channel for the integration of audiovisual signals. To account for the present results, we developed a biologically-inspired, general-purpose model for multisensory integration, the Multisensory Correlation Detectors, which combines correlated input from unimodal transient channels. Besides accounting for the results of our psychophysical experiments, this model could quantitatively replicate several recent findings in multisensory research, as tested against a large collection of published datasets. In particular, the model could simultaneously account for the perceived timing of audiovisual events, multisensory facilitation in detection tasks, causality judgments, and optimal integration. All-in-all, this study demonstrates that several phenomena in multisensory research that were previously considered unrelated, all stem from the integration of correlated input from unimodal transient channels.
Single Chain Fragment Variable (scFv) corresponding to a novel epitope within HCV envelope protein restricts virus entry into hepatocytes
Authors: Das Soma , Behera Padmanava , Shewale Dipeshwari J , Bodele Janhavi , Das Saumitra , Karande Anjali A 
Published: July 2023

AbstractHepatitis C virus (HCV) is a leading cause of chronic viral hepatitis. The use of neutralizing antibodies could be a more effective therapeutic option. Previously we reported the discovery of a novel epitope at the C terminus of HCV-E2 protein, that induced potent neutralizing antibodies in the infected patients. Furthermore, monoclonal antibodies generated against this epitope could also significantly reduce virus replication in a cell culture system. In this study, we have focused on the generation of single chain variable fragments of this unique neutralizing monoclonal antibody A8A11 raised against the conserved epitope. The nucleotide sequence of the neutralizing monoclonal antibody A8A11 was determined and the scFv gene was constructed followed by cloning into the expression plasmid for recombinant protein expression. The scFv mimicked the antibody in binding to the hepatitis C virus like particles (HCV-LP). As expected, the scFv inhibited HCV-LP binding to hepatocytes and could effectively reduce viral replication in the cell culture system. More importantly, scFv A8A11 could restrict serum HCV RNA levels in HCV-infected chimeric mice harboring human hepatocytes. Results provide a basis for developing a promising scFv-based entry inhibitor, which could be more effective against viruses refractory to drugs targeting viral enzymes.
SPH method used for characteristic predictions at Pelton turbine buckets: comparing with the mesh-based method
Authors: Sun Jie , Ge X.F. , Zheng Yuan 
Published: July 2023

PurposeThe research in this paper helps to understand the difference between the Eulerian method and the Lagrangian method in describing the performance of Pelton turbine buckets, so as to improve the design level and design efficiency of the runner.Design/methodology/approachThis paper used DualSPHysics to calculate the unsteady flow of the Pelton turbine runner bucket and compared it with the mesh-based method to explore the difference between mesh-based and particle-based methods in torque curves, jet flow patterns and pressure characteristics.FindingsIt is noted that the particle-based method is challenging to compare with the mesh-based method concerning accuracy. In addition to better describing the free water film, the particle method also captures many droplets near the water film, but it cannot well describe the negative pressure region on the bucket back and the resulting jet interference after cutting off the jet. Compared with the mesh-based method, the pressure measurement points obtained by the particle-based method generally have shorter periods and violent fluctuations, and the pressure value of some points is underestimated.Originality/valueThis paper helped to calculate the unsteady characteristics of the Pelton turbine by Fluent, CFX and DualSPHysics; exploration jet flow pattern differences between the mesh and meshfree methods; prediction of the flow interference between the bucket back and the jet and the pressure curve of SPH usually has a shorter period and violent fluctuations.
Does funded research have a greater scholarly impact? A study of funded and non-funded research published in high-impact library and information science journals
Authors: Ali Altaf , Nazim Mohammad 
Published: July 2023

Purpose
This study aims to examine the scholarly impact of funded and non-funded research published in ten core library and information science (LIS) journals published in 2016.

Design/methodology/approach
In total, ten high-impact LIS journals were selected using Google Scholar metrics. The source title of each selected journal was searched in the Scopus database to retrieve the articles published in 2016. The detailed information of all the retrieved articles for every journal was exported in a CSV Excel file, and after collecting all the journal articles’ information, all CSV Excel files were merged into a single MS Excel file for data analysis.

Findings
The study analyzed 1,064 publications and found that 14% of them were funded research articles. Funded articles received higher average citation counts (24.56) compared to non-funded articles (20.49). Funded open-access articles had a higher scholarly impact than funded closed-access articles. The research area with the most funded articles was “Bibliometrics,” which also received the highest number of citations (1,676) with an average citation count of 24.64. The National Natural Science Foundation of China funded the most papers (30), while the USA funded the highest number of research publications (36) in the field of LIS.

Practical implications
This study highlights the importance of securing funding, open access publishing, discipline-specific differences, diverse funding sources and aiming for higher citations. Researchers, practitioners and policymakers can use these findings to enhance research impact in LIS.

Originality/value
This study explores the impact of funding on research LIS and provides valuable insights into the intricate relationship between funding and research impact.
Migration in India under structural transformation
Authors: Liu Yiming 
Published: July 2023

Purpose
This study aims to answer if inter-state migrants in India play a more active role than their intra-state counterparts in labor force participation and entrepreneurship.

Design/methodology/approach
A recursive bivariate probit model is used with an instrumental variable (IV) of the total of inter-state migrants in a city over their historical numbers to tackle the endogeneity issue of the migration decision of the migrants.

Findings
Inter-state migrants did a better job than their intra-state counterparts in labor force participation and female inter-state migrants did a better job than their counterparts in wage employment and being day laborers.

Research limitations/implications
The data are from IPUMS and there is no updated nationwide data regrading migration and employment for recent years.

Practical implications
A randomized controlled trail can be carried out near the borders of two states where there are both significant amounts of inter-state and intra-state migrants.

Social implications
The government and international organizations shall focus on cultivating the skills of the female migrants as well as encouraging the entrepreneurship of both types of migrants.

Originality/value
The study focus is on the comparison between intra- and inter-state migrants based on nationwide survey data and the usage of recursive bivariate model and an effective Instrumental Variable.
Influence of applied pressure on the tribological behaviors of a wet multi-disc clutch during the running-in process
Authors: Wang Qian , Ma Biao , Yu Liang , Chen Man , Wang Guoyu , Zheng Liangjie 
Published: July 2023

Purpose
This paper aims to explore the influence of applied pressure on the tribological properties of the friction component in a wet multi-disc clutch during the running-in process.

Design/methodology/approach
The running-in evolutionary was explored in terms of global friction performance. The variation of friction torque and mean COF of the initial 300 engagement cycles was obtained by full-scale tests. Finally, an optical microscope was used to detect the wear characteristics of friction surfaces.

Findings
The applied pressure showed a significant influence on the tribological behaviors of wet clutches during the running-in process. The mean COF decreased and then increases with the increase of the applied pressure. A higher applied pressure contributed to more asperity summits being sheared, thus resulting in a smoother surface. Considering a suitable wore performance, properly applied pressure is necessary.

Originality/value
The results provide theoretical guidance for selecting the optimal applied pressure in the running-in of wet clutches.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-08-2022-0256/
Addressing grand challenges: perceptions of interdisciplinary research and how communication structures facilitate interdisciplinary research at US research-intensive universities
Authors: Lemon Laura L. , VanDyke Matthew S. 
Published: July 2023

PurposeThe purpose of this research was to understand the role of interdisciplinarity in research and how communication structures and processes at universities facilitates such work.Design/methodology/approachTwenty-one semi-structured interviews with administrators, faculty, and staff from US R-1 Carnegie-designated higher education institutions were conducted.FindingsInstitutional culture reportedly drives interdisciplinary research efforts and participants offered different values associated with pursuing interdisciplinary work. Participants also shared formal and informal incentives that motivate their pursuit of interdisciplinary collaborations. Participants seemed to prefer a blended centralized-decentralized approach for the communication function's support of interdisciplinary research efforts.Originality/valueThis research fills a gap in understanding of how organizational capacities, structures and processes support collaborative research work and public communication about such work.
Exploring perceived online information quality: a mixed-method approach
Authors: Ju Boryung , Stewart J. Brenton 
Published: July 2023

Purpose The purpose of this study is to examine the quality of information in articles in the online encyclopedia, Wikipedia, as perceived by readers and content contributors. This study explored several dimensions and characteristics of information presented in Wikipedia by identifying new emerging dimensions in terms of readers’ perceptions of the quality of online information.Design/methodology/approach Two rounds of online surveys were conducted using a mixed-method approach. In the first survey, the authors conducted content analysis on 197 participants, and in the second survey, the authors conducted factor analysis on 107 study participants. The authors used Qualtrics Panel Services to recruit individuals who read and/or edited the English version of Wikipedia articles and resided in the United States.Findings The mixed-method approach employed in this study to explore the quality of online information had three core components: users’ perceptions of information quality, content analysis, and exploratory factor analysis of the perceived information quality structure. The study found a new information quality category, social aspect quality. Dimensions include fun, goodness, empowering and user generated.Originality/value The results demonstrate the emergence of novel quality attributes for information quality presented online, particularly in social media. Moreover, this study is one of the rare studies to employ a mixed-method approach that offers diverse but reliable perspectives on information quality as perceived by everyday users of Wikipedia.
System for classification of human gaits using markerless motion capture sensor
Authors: Madhana K. , Jayashree L.S. , Perumal Kalaivani 
Published: July 2023

PurposeHuman gait analysis is based on a significant part of the musculoskeletal, nervous and respiratory systems. Gait analysis is widely adopted to help patients increase community involvement and independent living.Design/methodology/approachThis paper presents a system for the classification of abnormal human gaits using a Markerless 3D Motion Capture device. This study aims at examining and estimating the spatiotemporal and kinematic parameters obtained by 3D gait analysis in diverse groups of gait-impaired subjects and compares the parameters with that of healthy participants to interpret the gait patterns.FindingsThe classification is based on mathematical models that distinguish between normal and abnormal gait patterns depending on the deviations in the gait parameters. The difference between the gait measures of the control and each disease group was examined using 95% limits of agreement by the Bland and Altman method. The scatter plots demonstrated gait variability in Parkinsonian and ataxia gait and knee joint angle variation in hemiplegic gait when compared with those of healthy controls. To prove the validity of the Kinect camera, significant correlations were detected between Kinect- and inertial-based gait tests.Originality/valueThe various techniques used for gait assessments are often high in price and have existing limitations like the hindrance of components. The results suggest that the Kinect-based gait assessment techniques can be used as a low-cost, less-intrusive alternative to expensive infrastructure gait lab tests in the clinical environment.
Conceptualizing condominium law and children: comparing the state of strata titles law in New South Wales and Singapore
Authors: Tang Hang Wu 
Published: July 2023

Purpose
This paper aims to adopt a comparative method using case law, statutes and secondary literature across both jurisdictions. This paper also draws on various theories of property ownership.

Design/methodology/approach
This paper conceptualises the legal relations embedded within condominium housing and the various theories of property ownership to ascertain how children’s interest fit within this framework. The laws of two jurisdictions, New South Wales and Singapore, are examined to determine how their strata law responds when children’s safety is at stake.

Findings
Drawing on pluralist moral theories of property law, the thesis advanced is that children’s issues within condominiums should not be subject to majoritarian rule especially when their safety is at stake. The paramount guiding value should be ensuring their safety within multi-owned housing communities. Using the law of two jurisdictions, New South Wales and Singapore, the central argument of this paper is that the law in these jurisdictions has rightfully adopted a protective approach towards children in multi-owned properties where their safety is at stake.

Originality/value
The literature on the law of multi-owned housing has largely focused on governance issues such as mediating between the majority owners’ interest with that of the minority owners’ interest. Children in multi-owned developments remain an under investigated area as children’s interests do not fit within the paradigm of majority versus minority interests. The paper advances the argument that children’s interest should be viewed through either a rights-based theory or pluralists’ theories of property law. Lessons from the New South Wales and Singapore experience are also drawn which might prove useful to other jurisdictions.