bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Cause of Hypercalcemia In Adults: Idiopathic Infantile Hypercalcemia
Authors: Ünal Fatma Tuğçe Şah , Aydemir Esra Eraslan , Leblebici Can Berk , Kutlay Nüket Yürür , Erdoğan Murat Faik 
Published: January 2025

Abstract

Idiopathic Infantile Hypercalcemia (IIH) is a rare disorder marked by PTH-independent hypercalcemia, usually diagnosed in infancy, with adult cases being uncommon. This report discusses a 60-year-old male with a 25-year history of type 2 diabetes, recurrent kidney stones, and stage 3a chronic kidney disease. Laboratory findings included hypercalcemia, normal phosphorus and 25-hydroxycholecalciferol levels, and suppressed PTH. Urinary ultrasonography revealed medullary nephrocalcinosis. Comprehensive evaluation ruled out malignancies, granulomatous diseases, and endocrinopathies. Genetic testing identified compound heterozygous mutations in the CYP24A1 gene, confirming IIH type 1. Initial management involved calcium- and vitamin D-restricted diets and sunlight avoidance. When hypercalcemia persisted, fluconazole treatment (50 mg/day) was trialed but proved ineffective. Cinacalcet (60 mg/day) was subsequently introduced, successfully normalizing serum calcium levels. Family genetic screening revealed biallelic mutations in two siblings and heterozygous mutations in two others, though none exhibited hypercalcemia. This case underscores the need for heightened awareness of IIH in adults, advocating for family screening to detect asymptomatic carriers early. The effectiveness of cinacalcet in managing adult IIH highlights its therapeutic potential when lifestyle modifications alone are insufficient, preventing long-term complications from untreated hypercalcemia.
A Hierarchical Key Assignment Scheme
Authors: Celiktas Baris , Celikbilek Ibrahim , Guzey Sueda , Ozdemir Enver 
Published: January 2025

Abstract

This work introduces a novel access control scheme employing a hierarchical key assignment mechanism based on inner product spaces. The scheme is computationally lightweight and designed for digital environments with hierarchical access control policies. By leveraging orthogonal projection and distributing a basis to each group, it supports flexible and efficient left-to-right and top-down policies, accommodating dynamic updates in the hierarchy. The scheme allows parent groups to derive the secret keys of their child groups while preventing the reverse. It ensures resistance to collusion attacks and privilege creep, offering key recovery and indistinguishability properties. With low storage overhead and an efficient key derivation process, the scheme provides a practical solution for secure hierarchical access control.
Identification of Cell Death Markers in Keratinocytes Due to Cryopreservation with Various DMSO Concentrations
Authors: Čechová Katarína , Štibrániová Iveta , Gálfiová Paulína , Balcerzak Łucja , Kosnáč Daniel , Kĺbik Ivan , Waczulíková Iveta , Šikurová Libuša 
Published: January 2025

Abstract

Cryopreservation of cells is a critical challenge in contemporary cryobiology, particularly in the burgeoning field of tissue engineering. The method of cryopreservation significantly affects the quality of cells post-thaw, as cells are sensitive to the stress induced by freezing and thawing, leading to physical damage, loss of functionality, or cell death. It is essential to develop protocols that ensure good physiological and adherent conditions post-thaw. This study investigates the effect of cryopreservation on human keratinocytes using the intracellular cryoprotective agent dimethyl sulfoxide (DMSO), known for mitigating cell damage during freezing and thawing, although its toxicity remains debated.
We evaluated the cryopreservation of human keratinocytes with low (1.8% and 2.2% v/v) and standard (5% and 10% v/v) concentrations of DMSO during short-term storage (4 days) at -80°C. Post-thaw, we examined the impact of the cryopreservation process on cell viability, plasma membrane fluidity, and identified signs of cell death depending on the concentration of DMSO used in the freezing medium. This study is the first to systematically examine the impact of various DMSO concentrations on cell viability and plasma membrane fluidity of keratinocytes in the context of 30% FBS concentration in the freezing medium, slow cooling, and − 80°C temperature, highlighting the originality and significance of our research.
This research demonstrated that lower DMSO concentrations (1.8% and 2.2%) significantly reduce keratinocyte viability due to increased apoptotic activity and cellular stress. In contrast, higher concentrations (5% and 10%) provide better protection and maintain higher cell viability. The study revealed that membrane fluidity increases with higher DMSO concentrations, which may facilitate the clustering of death receptors and the formation of apoptotic signaling complexes, thereby increasing the sensitivity of keratinocytes to apoptotic stimuli. Morphological analysis showed that lower DMSO concentrations lead to significant morphological changes and apoptosis, while higher concentrations result in cell enlargement and shape alteration. Ultrastructural analysis provided detailed insights into the internal structure of cells, revealing changes in the nucleus, mitochondria, and the presence of vesicles around the plasma membrane at lower DMSO concentrations, whereas higher DMSO concentration led to significant nuclear damage. These findings have implications for cryopreservation to improve cell viability and functionality post-thaw and may enhance the success of cell preservation in biomedical applications.
Broadband single-polarization single-mode low confinement loss hollow core anti -resonant fiber with semi-elliptical nested tube
Authors: Lin Wen , Fei Yihong , Wang Ning , Jia Hongzhi 
Published: January 2025

Abstract

In this paper, a hollow-core anti-resonant optical fibre containing a semi-elliptical nested tube is proposed, which has the characteristics of single-polarization, large bandwidth, single- mode and low confinement loss. By optimizing the structural design, the polarization extinction ratio (PER) of the fiber reaches 21,0183 at a wavelength of 1.55μm, and the y-polarized fundamental mode (FM) loss is only 0.00086 dB/m. By changing the material and thickness of the semi-ellipsoidal nested tube, a large bandwidth of 280 nm was achieved in the wavelength range of 1.51-1.78 μm, with loss limited to less than 0.001 dB/m within the bandwidth range. The PER and higher-order mode extinction ratio (HOMER) of 4870, 1487, respectively. The loss remains below 0.01 dB/m when the bending radius exceeds 4.5 cm. Therefore, it is expected that this optical fiber can be used in optical devices such as fiber optic sensors, fiber optic lasers and fiber optic gyroscopes.
Comparative analysis and trend prediction of research progress in medical teaching management-- Research on Web of Science Literature Based on CiteSpace (2014-2023)
Authors: Yu Wen , Zhou Xinyu , Xu Ming , Zhao Ziming , Guo Dong , Liu Ying 
Published: January 2025

Abstract

Background
With the increase of medical demand, the teaching quality of medical universities was highly valued by all sectors of society. How to innovate the teaching management mode in the new era was an important problem faced by all universities. In the past decade, many research hotspots have emerged in medical teaching management. The research of the latest literature in this period can help us grasp the frontier dynamics of this field, which was of great significance to the development of higher medical education.
Methods
From Web of Science,we searched for studies published between 2014 and 2023 using the terms “medical education” and “teaching management”, ended up with 1407 eligible papers. CiteSpace software was used to visually analyze the research institutions, authors and keywords of the studies.
Results
The number of research on medical teaching management had shown a steady increase trend in the past decade. BMC MEDICAL EDUCATION was the journal with the largest number of publications. Durning, Steven J., of the Uniformed Services University of the Health Sciences - USA, was the most prolific author. Literature research in the field of medical teaching management had many research directions but not deep enough.
Conclusions
As the core author group had not yet been formed and the team effect cannot be brought into play. Organized teaching research that can efficiently integrate resources and cooperatively complete tasks was urgently needed.Literature research in the field of medical teaching management had many research directions but not deep enough. This study identified three characteristics of medical teaching management research in recent years: people-oriented, application of high technology, and teaching reform. These topics can provide useful information for educators and researchers to continue in-depth research.
A Spherical Hybrid Energy Harvester for Marine Environments
Authors: Liu Hongmei , Li Shixiang , Ban Chuncheng , Dou Yanwei 
Published: January 2025

Abstract

The ocean represents a vast reservoir of kinetic energy with tremendous potential for energy harvesting. During extreme adverse weather conditions, the GPS signal of a vessel may be interfered with, posing a risk of hitting reefs while navigating shipping lanes. This paper focuses on the models of regular ocean waves and wind-induced waves,we show a piezoelectric photovoltaic energy harvester based on a sealed spherical structure, which can be used as a self-powered marine floating light for guidance and warning in harsh environments..The system consists of three main components: a piezoelectric module, a photovoltaic module, and an energy storage module. The piezoelectric module comprises two piezoelectric sheets that generate electricity through deformation induced by continuous fluctuations. The photovoltaic module consists of flexible amorphous silicon, which produces the photovoltaic effect under light exposure. The energy harvested from the piezoelectric and photovoltaic modules is rectified, regulated sand stored in the energy storage module. Experimental results show that the energy harvester can achieve a power of 1.35mW, demonstrating the promising potential of the hybrid energy harvester for practical applications in marine environments.
Implementing telemedicine for medical abortion within the public health system: A qualitative study on implementation bottlenecks and solutions in South Africa
Authors: Storey Simone , Cleeve Amanda , Endler Margit 
Published: January 2025

Abstract

Background
Abortion in South Africa is legal, but there are still many barriers to access and high utilisation of the informal sector. Telemedicine for medical abortion is an alternative model that has been found to be a safe, effective, and acceptable option to increase access to abortion services. This study aimed to understand how key informants view telemedicine for medical abortion and how they view potential bottlenecks and solutions concerning implementation in the public sector of South Africa.
Methods
Interviews were conducted between February and March 2023 with 19 experts across telemedicine and medical abortion provision, policy, and research. The study had a qualitative design and interviews were analysed using inductive content analysis. Baker et al.’s model of the implementation pathway was used to conceptualise and discuss the findings.
Results
The findings showed that telemedicine was perceived as a valuable complement to in-clinic care to increase access to safe abortions. Respondents identified clinical concerns and logistical challenges as implementation bottlenecks which could be overcome with innovative thinking and by drawing on existing resources. Research, leadership, collaboration, and policy alignment were suggested to increase stakeholder willingness and capacity to build health system readiness. Across the implementation process, it was viewed as necessary to consider users’ needs and adapt to contextual differences.
Conclusions
Telemedicine was found to be a valuable model for increasing access to safe abortion services. Considerations and actionable steps to overcome implementation bottlenecks were provided to guide implementing telemedicine for medical abortion in the public sector of South Africa and similar settings.
Embryology and character evolution in the tribe Stewartieae (Theaceae)
Authors: Takagi Mina , Tokuoka Toru 
Published: January 2025

Abstract

The Theaceae family, consisting of nine genera within three tribes, is classified under the order Ericales. While embryological studies of the tribes Theeae and Gordonieae are well-documented, research on the tribe Stewartieae, the earliest diverging lineage within the family, remains limited. To address this gap, we conducted a literature review and examined three species of Stewartia (S. monadelpha, S. pseudocamellia, and S. serrata) to elucidate the evolutionary trajectories of embryological characters in Theaceae. Our findings propose novel evolutionary polarities in these characters. The absence of vascular bundles in the integuments is identified as a plesiomorphy, while their presence in the inner integument of Theeae and the outer integument of Gordonieae represents respective apomorphies. Ribbed pseudopollen grains are a plesiomorphy, whereas a clade comprising Franklinia and Schima exhibits porous pseudopollen grains and an anther middle layer with more than three cell layers, which are shared as synapomorphies. Stewartieae possess a bitegmic ovule, a character that Theaceae share as a synplesiomorphy with Pentaphyllaceae and Sladeniaceae. In contrast, the unitegmic ovule is a synapomorphy for a clade that includes the Ericoid, Sarracenioid, and Styracoid families. Both integuments in Stewartieae are of dermal origin, and the transition from bitegmic to unitegmic ovules involves the development of a subdermatogen at the base of the integuments. The presence of endothelium and hypostase are synapomorphies of the family. Additional evolutionary trends in embryological traits within Theaceae are discussed in detail.
Designing an efficient Deep Dyna Q based VARMAx Model for Prediction of Real-Time changes in Stock Value Patterns
Authors: Sable Rachna , Singh Aman , Gupta Sudhanshu , Parlewar Pallavi 
Published: January 2025

Abstract

In the intricate complexities of modern financial markets, the capability to predict stock values with high accuracy stands as a cornerstone for investors and analysts alike. Existing methods still struggle with the complex dynamics of markets, especially in adapting to stock fluctuations' multifaceted nature. In response to these limitations, the proposed work introduces a ground-breaking approach that integrates the robust forecasting capabilities of VARMAx with the adaptive ability of Deep Dyna Q algorithms. The rationale for this integration is rooted in the quest to enhance the responsiveness and accuracy of stock value predictions. The model's performance was evaluated using datasets from the Indian and USA markets. It showed significant improvements in precision, accuracy, recall, AUC, and specificity, as well as a substantial reduction in response time. These enhancements are crucial for financial decision-making, where accuracy and timeliness are essential.
Evaluating the Health and Fitness Benefits of a 6-Month FES-Cycling Program on a Recumbent Trike for Individuals with Motor Complete SCI: A Pilot Study
Authors: Sanna Nicole , Nossa Roberta , Biffi Emilia , Guanziroli Eleonora , Diella Eleonora , Ferrante Simona , Molteni Franco , Peruzzo Denis , Nicola Casali , Alfonso Mastropietro , Rizzo Giovanna , Tarabini Marco , Pedrocchi Alessandra , Ambrosini Emilia 
Published: January 2025

Abstract

Background: Spinal cord injury (SCI) severely affects physical function, leading to muscle atrophy and reduced bone density. Sport-therapy, incorporating recreational and competitive activities, has shown promise in enhancing recovery for individuals with SCI. Functional Electrical Stimulation (FES)-cycling combines exercise benefits with stimulation advantages, and recent integration with mobile recumbent trikes adds further potential. This study aimed to evaluate the effects of a 6-month FES-cycling sport therapy using a recumbent trike on individuals with motor complete SCI.
Methods: Five participants engaged in bi-weekly FES-cycling sessions using an instrumented recumbent trike. A comprehensive assessment was conducted before training, at 3 and 6 months of training, and at 1-month follow-up. Outcome measures included maximal muscle Cross-Sectional Area (maxCSA) from Magnetic Resonance Images, bone mineral density, clinical scales, and questionnaires on spasticity, pain, bowel dysfunction, psychological well-being, and sport motivation. Additionally, maximal power output and cycling endurance were assessed.
Results: The FES-cycling program led to a significant increase in muscle mass of 34% after 6 months of training, correlated to an improved cycling performance (maxCSA versus peak power). A slight decrease of muscle mass was observed as expected at follow-up. Participants reported high well-being and strong motivation throughout the training program. Bone health, spasticity, bowel dysfunction, and pain levels did not significantly change overall.
Conclusions: FES-cycling on a recumbent trike shows potential as a therapeutic and recreational activity for individuals with SCI. It significantly improved muscle mass and physical performance while positively impacting psychological well-being and motivation. Further research with larger cohorts is necessary to confirm these benefits and optimize protocols, establishing FES-cycling as a valuable sport-therapy model for SCI.
Trial registration: The study protocol was retrospectively registered on clinicaltrials.gov (NCT06321172) due to technical issue.
A Very Low–Carbohydrate Program in Adults With Metabolic Dysfunction–Associated Steatotic Liver Disease and Phospholipase Domain–Containing Protein 3 Risk Genotype: Pre-Post Intervention Study
Authors: Saslow Laura R , Krinock Jamie , O'Brien Alison , Raymond Kaitlyn , Bayandorian Hovig , Moskowitz Judith T , Daubenmier Jennifer , Oliveri Antonino , Marriott Deanna J , Griauzde Dina H , Speliotes Elizabeth K 
Published: January 2025

Abstract

Background
Insulin resistance and the G allele of rs738409 interact to create a greater risk of metabolic dysfunction–associated steatotic liver disease.

Objective
This study aims to confirm that one promising way to reduce insulin resistance is by following a very low–carbohydrate (VLC) dietary pattern.

Methods
Adults with rs738409-GG or -CG with liver steatosis and elevated liver function tests, were taught an ad libitum VLC diet, positive affect and mindful eating skills, goal setting, and self-monitoring and given feedback and coaching for 4 months. We measured liver steatosis, anthropometric, serum metabolic diet adherence, and quality of life measures.

Results
In this small pilot trial, of the 11 participants enrolled, 9 (82%) participants completed outcomes. All 11 participants viewed at least 1 session of the intervention, and 8 (73%) participants viewed at least half of the sessions. Among the 9 participants who provided 4-month self-report information, intervention satisfaction was high (mean 6.22, 95% CI 5.58-6.85), with 5 (56%) participants rating the intervention the top score, and 4 (44%) participants reporting they did not plan to stop following the VLC diet. Across participants with a 4-month hepatic liver fat percent measurement, the percent change in liver fat was −33.17% (95% CI −86.48 to 20.14), and in only the participants who were adherent to the eating pattern, the percent change in liver fat was −53.12% (95% CI −71.25 to −34.99). Amongst participants with a 4-month hepatic liver fat percent measurement, 6 out of 8 (75%) participants were considered responders, with a relative decline in liver fat ≥30%, and of the 9 participants with a 4-month body weight, 9 (100%) participants lost ≥5% of their body weight. There were no serious adverse events.

Conclusions
Results suggest the feasibility, acceptability, and preliminary efficacy of the VLC intervention in adults with higher genetic risk for metabolic dysfunction–associated steatotic liver disease, although there is a need for further studies given the small sample size and the high risk of substantial biases in this small pilot study.
Prolapsus Rektum Pada Domba Dorper (Case Report: Rectal Prolapses in Dorper Sheep)
Authors: Prastiwi Artina , Adji Dhirgo , Anggraeni Rr. Devita , Purnomo Agus , Ramadhani Mungky Emma 
Published: January 2025

Prolaps rektum merupakan tonjolan jaringan rektal di luar anus. Faktor penyebab prolaps rektum pada hewan muda dan tua meliputi konstipasi, endoparasit, diare, faktor keturunan, kehilangan daya spinchter ani dan pelonggaran selaput lendir rektum. Hewan kasus adalah tiga ekor domba Dorper berasal dari Wonosari, Gunungkidul dengan keluhan prolaps rektum selama 3-4 hari, nafsu makan menurun dan domba masih aktif. Domba pertama betina 50 kg berusia 2.5 tahun, domba kedua betina 30 kg berusia 5 bulan, dan domba ketiga jantan 35 kg berusia 5 bulan. Pemeriksaan fisik menunjukkan gejala klinis primer prolapsus rektum berupa massa silindris memanjang yang menonjol melalui lubang anus, bagian proksimal rectum berwarna merah muda sedangkan bagian distal berwarna merah, serta terdapat peradangan pada mukosa rektum. Tindakan operasi dilakukan untuk reposisi rektum. Premedikasi menggunakan Acepromazine, dilanjutkan injeksi anestesi epidural menggunakan Lidocaine. Anestesi lokal Lidocaine line block diinjeksikan di sekitar anus. Rektum dimasukkan perlahan secara manual, kemudian dilakukan penjahitan di sekeliling anus dengan pola purse string agar rektum tidak kembali prolaps. Terapi post operatif diberikan injeksi antibiotik broad spectrum Amoxicillin dengan sediaan 150 mg/ml (1 ml/10kg BB) dan injeksi antiinflamasi (NSAIDs) Flunixin Meglumine 50 mg/ml (0,02-0,04 ml/kg BB; q12h). Domba Dorper jantan dipotong karena mengalami prolaps rektum berulang dan lemah.
The Edmonton Encampment Litigation and The Charter Claims We Didn’t (Get to) Argue
Authors: Lund Anna 
Published: January 2025

In recent years, the number of unhoused and unsheltered individuals in Canada has risen dramatically. In urban centres across Canada, unsheltered individuals have gathered together in encampments for safety and a sense of community. Municipalities frequently respond to these encampments by forcibly evicting them. In autumn 2023, the Coalition for Justice and Human Rights filed a claim on behalf of Edmonton’s encampment residents, alleging their rights and freedoms, as enshrined in the Canadian Charter of Rights and Freedoms sections 2, 7, 8, 12, and 15, were unjustifiably infringed by the City of Edmonton'’s encampment displacement policies and practices. The case was struck on a preliminary ground, because the court held that the Coalition lacked public interest standing, and thus the court never made a decision on the merits of the Coalition's Charter claims. This article provides a procedural chronology of the Edmonton encampment case and sets out the Charter arguments that the Coalition planned to advance. In doing so, this article aims to offer guidance to others engaged in encampment litigation, to broaden the conversation about how the Charter is implicated in encampments and governmental responses to them, and to give voice to the unhoused individuals, who provided evidence in support of the Coalition's lawsuit.