bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Sikap Bahasa Penutur terhadap Kematian Bahasa Kerinci dengan Model Sistem Persamaan Diferensial
Authors: Salsabila Faradhiba , Hafidi Deden Usman , Widianingrum Tyla Safitri , Setiawan Bayu , Pahlevi Raihan Dzul Alfaini , Darmayanti Nani 
Published: December 2022

Badan Bahasa mengklasifikasikan bahasa Kerinci sebagai bahasa yang stabil, tetapi terancam punah. Kepunahan suatu bahasa daerah disebabkan oleh penutur generasi muda yang mulai meninggalkan bahasa daerahnya sehingga tidak ada lagi yang mewarisi kemampuan berbahasa daerah. Penelitian ini bertujuan untuk mencari sikap bahasa penutur bahasa Kerinci, penyebab dari sikap bahasa tersebut, dan memprediksi kepunahan bahasa Kerinci menggunakan sistem model persamaan diferensial. Metode yang digunakan adalah metode gabungan. Hasil penelitian ini menunjukkan bahwa remaja di Kabupaten Kerinci dan Sungai Penuh menunjukkan sikap bahasa netral cenderung positif dengan rata-rata nilai 0,599 dari seluruh ranah. Terdapat dua faktor yang memengaruhi sikap bahasa para remaja tersebut, yaitu pengajaran bahasa Kerinci secara informal dan faktor lingkungan yang mendukung pemilihan bahasa Kerinci. Simulasi numerik mengenai kepunahan bahasa Kerinci dilakukan menggunakan model matematika dinamik dengan tiga kompartemen (penutur monolingual bahasa Kerinci, monolingual bahasa Indonesia, dan penutur bilingual) dan menambahkan faktor sikap bahasa. Nilai tiap parameter didapat dari hasil kuesioner, seperti proporsi jumlah penutur, tingkat kontak antar penutur dan sikap bahasa. Simulasi numerik dilakukan dengan metode Runge-Kutta-Fehlberg dan software Maple. Simulasi numerik menunjukkan sikap bahasa berpengaruh dalam mempertahankan populasi bilingual bahkan dapat meningkatkan populasi bilingual pada angka tertentu.
Kata kunci:
sikap bahasa, bahasa Kerinci, sosiolinguistik, model kepunahan bahasa, model persamaan diferensial
Medindo a pobreza multidimensional em Itabuna: uma análise espacial
Authors: Barreto Ricardo Candéa Sá , Santos Eli Izidro dos , Carvalho Ícaro Célio Santos de 
Published: December 2022

Este estudo objetivou analisar a pobreza multidimensional dos bairros de Itabuna em 2010, por meio da utilização de ferramentas de análise espacial. Utilizou-se uma metodologia que considera outras variáveis, além da renda, que igualmente privam os cidadãos, para realização do cálculo do Índice de Pobreza (IP). A organização dos bairros em rankings de pobreza demonstrou que os índices são consistentes para o estudo e a espacialização da pobreza em Itabuna. Foram encontradas alta concentração de pobreza em diversas áreas do município e baixa concentração nas áreas centrais. Complementarmente, a utilização do modelo de Mínimos Quadrados Generalizados Factíveis (MQGF) apontou os determinantes da condição de pobreza cuja influência é negativa: renda média, proporção de lojas comerciais e de unidades de saúde, enquanto o analfabetismo demonstrou influenciar positivamente. Palavras-chave: Cluster. Distribuição espacial. Pobreza. Desigualdade social. Itabuna.
A time relic: a new species of dwarf boa, Tropidophis Bibron, 1840 (Serpentes: Amerophidia), from the Upper Amazon Basin
Authors: Ortega-Andrade H. Mauricio , Bentley Alexander , Koch Claudia , Yánez-Muñoz Mario H. , Entiauspe-Neto Omar M. 
Published: December 2022

The amerophidian snake radiation is a Late Cretaceous superfamily that encompasses two families: Aniliidae, pipe snakes, and Tropidophiidae, dwarf boas. We describe a new dwarf boa snake species, from the Tropidophiidae family, from the cloud forest in northeastern Ecuador. Tropidophis cacuangoae sp. nov. can be diagnosed from its congeners based on external and osteological morphology. The new species inhabits eastern tropical piedmont and lower evergreen montane forests, in the Amazon Tropical Rainforest biome, and is likely to be an Ecuadorian endemic. We also discuss the relationships of the new species with South American tropidophiids and provide a key to the identification of mainland South American dwarf boas.
AKUNTABILITAS KEBIJAKAN DALAM PELAKSANAAN PEMBANGUNAN FISIK RABAT JALAN DAN GEDUNG BUMDes (Studi di Desa Kasembon, Kecamata Kasembon, Kabupaten Malang)
Authors: Manis Arum , Hadiwiyono Hadiwiyono 
Published: December 2022

Akuntabilitas publik adalah tugas agen (Pemerintah) untuk mengelola dan melaporkan sumber daya sertamengungkapkan semua kegiatan dan kegiatan yang terkait dengan penggunaan sumber daya publik kepadapemberi delegasi. Penelitian ini bertujuan untuk mengetahui dan menganalisis akuntabilitas kebijakan PemerintahDesa Kasembon Kec dalam pelaksanaan pembangunan fisik jalan dan rabat arsitektur BUMDes oleh PemerintahDesa. Kabupaten Kasenbon Maran. Jenis penelitian yang digunakan dalam penelitian ini menggunakanpendekatan kualitatif. Tujuan Menggunakan Teknik Pengumpulan Data Teknik pengambilan sampel yangmenggunakan sampling adalah wawancara, observasi, dan dokumentasi. Sumber data survei terdiri dari dataprimer dan data sekunder. Metode analisis data yang digunakan dalam penelitian ini adalah model analisis datainteraktif (interactive model) dari Milles and Hubberman dan Saldana.Akuntabilitas pembangunan yang diupayakan oleh Pemerintah Desa Palmdale adalah dengan melibatkanberbagai pemangku kepentingan dalam rencana pembangunan fisik desa, antara lain yang terlibat dalam DewanDesa Palmdale, Masyarakat, KPMD, PKK, Termasuk fasilitator desa, PLD. Jalan dan Rabat Fisik BUMDPembangunan yang diupayakan oleh Pemerintah Desa Kasembon akan memungkinkan pembangunaninfrastruktur enam tahap pada tahun 2019, sesuai dengan ketentuan dan peraturan yang berlaku mengacu padaUndang-Undang Nomor 6 Tahun 2014 tentang Desa meningkat. Akuntabilitas SDM, sebagian besar perangkatdesa masih berpendidikan SMA, sehingga akan sulit jika kebijakan diubah. Masalah selanjutnya adalah informasiyang dikenali masih mencukupi.

Kata Kunci :
Akuntabilas Kebijakan dalam Pelaksanaan Pembangunan Fisik Rabat Jalan dan GedungBUMDes oleh Pemerintah Desa
Asociación entre Shigella flexneri y la presencia de microulceraciones vulvovaginales en niñas peruanas prepúberes con vulvovaginitis específica
Authors: Corimanya-Paredes Jorge Manuel , Urbina-Alvarez Claudia Aracelli 
Published: December 2022

Introducción:La vulvovaginitis es uno de los principales motivos de consulta ginecológica en niñas prepúberes. No es común que las bacterias del género Shigella sean las causantes, pero se han reportado casos con lesiones típicas con microulceraciones. Objetivo: Encontrar asociación entre la infección por Shigella flexneri y la presencia de microulceraciones vestíbulo vaginales en niñas prepúberes que acudieron al Instituto Nacional de Salud del Niño (INSN) entre los meses de diciembre de 2008 y noviembre del 2009. Materiales y métodos: Se hizo un estudio observacional, analítico y transversal que evaluó una muestra de 149 niñas de 0 a 9 años mediante un muestreo sistemático. Los criterios de inclusión incluyeron pacientes con vulvovaginitis específica y hallazgos de microulceraciones; y a aquellos que no tenían la infección. Se utilizaron pruebas de bivariadas como chi-cuadrado, el test exacto de Fisher; además se calcularon medidas de asociación mediante modelos lineales generalizados. Resultados: Del total de pacientes, se encontró que el 56,5% dio positivo a Shigela flexneri y el 48,9% presentó microulceraciones y, de estos últimos, el 95,8% presentaron flujo sanguinolento (p<0,001). Asimismo, se encontró asociación entre la presencia de microulceraciones y el cultivo positivo a Shigella flexneri (p<0,001) y de la misma manera cuando se hizo la comparación otras especies de Shigella (p<0,001); estas diferencias significativas se perdieron en el análisis multivariable. Se encontró una asociación fuerte entre la presencia de flujo sanguinolento y la presencia de microulceraciones (RP=17,84; IC 95%: 5,21-61-05; p<0,001). Conclusión: Existe asociación entre el cultivo positivo a Shi ella flexneri y la presencia de microulceraciones vestibulovaginales en niñas prepúberes.
COMPARISON OF PERCUTANEOUS AND INTRAABDOMINAL BLOCKADES OF ILIOHYPOGASTRIC AND ILIOINGUINAL NERVES FOR POSTOPERATIVE PAIN MANAGEMENT OF TOTAL ABDOMINAL HYSTERECTOMY PATIENTS: A RANDOMIZED CONTROLLED CLINICAL TRIAL
Authors: DÜGER Cevdet , AVCI Onur , BOZTOSUN Abdullah , İSBİR Cemil , ÖZDEMİR KOL İclal , KAYGUSUZ Kenan , GÜRSOY Sinan 
Published: December 2022

Study Objective: In this study we aimed to determine whether iliohypogastric and ilioinguinal nerve blockade from intraabdominal approach for the postoperative pain management of total abdominal hysterectomy patients could be a reliable and effective alternative compared to percutaneous block of IHII nerves.
Design: This study is a randomised controlled double blind prospective clinical trial.
Setting: This study was conducted in operating room, and recordings were performed in postoperative recovery unit and gynaecology clinic.
Patients: Eighty seven women undergoing total abdominal hysterectomy were enrolled in this study but 82 completed the study. Patients were divided into three groups (n=29 in each), as control group (group C), percutaneous IHII block group (group PB) and intraabdominal IHII block group (group IB).
Interventions: Group C patients received no block procedure. The percutaneous bilateral IHII nerves block was performed after abdominal closure to group PB and intraabdominal IHII block was performed before abdominal closure to group IB.
Measurements: Mean arterial pressure, heart rate, pain scores, satisfaction scores, morphine consumptions and side effects were recorded at the 2nd, 6th, 12th and 24th postoperative hours.
Main Results: Postoperative MAP, HR results of control group were found similar in all groups. VAS scores at all postoperative hours were found to be significantly lower in the block groups PB an IB than control group. There were no significant differences in pain scores between group PB and IB at any time point. Morphine consumption data were found to be significantly lower in the PB and IB groups than in the control group.
Conclusions: Intraabdominal IHII blockade just before closure of the abdomen for relieving postoperative pain in total abdominal hysterectomy patients is as effective and safe method as conventional percutaneous IHII blockade without adverse effects.
The Relationship Between Anemia and Mortality in Elderly COVID 19 Patients
Authors: TAŞTEMUR Mercan , ARIK Güneş , HEYBELİ Hilal , SELVİ ÖZTORUN Hande , SİLAY Kamile , ATEŞ İhsan , HASTÜRK Denizcan , ÇAĞIR Büşra Betül , TUNA DOĞRUL Rana , ARAS Atacan , ÖZENÇ Erhan 
Published: December 2022

Background: COVID 19 continues to affect the whole world with its different presentations and unenlightened aspects.Older patients are the group most at risk. Low hemoglobin levels contribute to hypoxia during COVID 19 infection and increase the risk of complications, especially in risky groups. In this study, we aimed to investigate the prevalence of anemia and its effect on mortality in geriatric COVID 19 patients.
Materials and Methods: Data of 251 patients over the age of 65 who were followed up in the Internal Medicine services allocated for COVID 19 of our hospital between August and October 2020, were included in the study. Anemia was defined as a hemoglobin level of 13 mg/dl in men and below 12 mg/dl in women at the time of admission. Demographic and laboratory data of the patients and hemoglobin levels were compared.
Results: The mean age of 251 COVID-19 patients included in the study was 75.6±7.6 years. 45.8% (n:115) of the patients were female and 54.2% (n:136). While 51.8% of the patients had anemia, the presence of anemia was found to be 67.9% in patients who died due to COVID 19. According to multivariate logistic regression analysis, advanced age (OR=1.082; 95% CI=1.03-1.137; p=0.002), presence of anemia (OR=1.969; 95% CI=1.113-4.246; p=0.034),hypertension (OR =5.763; 95% CI=1.713-19.389; p=0.005), dementia (OR=3.614; 95% CI=1.128-11.578; p=0.031) were determined as independent risk factors predicting mortality in patients with COVID-19.
Conclusion: Advance age, presence of anemia, hypertension and dementia has been found as İndependant risk factors for mortality in COVID 19 infection in our study. In elderly Covid 19 patients hemoglobin levels at admission may be helpful in predicting mortality.
Prognosis Impact of Postoperative Dysnatremia in Cardiac Surgery under Extracorporeal Circulation
Authors: Chlouchi Abdellatif , Atmani Noureddine , Meskine Amine , Moujahid Azedine , El-Ghadbane Hatim , Drissi Mohamed 
Published: December 2022

Dysnatremias have several particular aspects concerning their etiology and evolution. They are associated with morbidity and mortality in various clinical contexts.
The Primary aim of our study is to evaluate the prognosis impact of postoperative dysnatremia in cardiac surgery under extracorporeal circulation.
Methods: This is a descriptive and analytical retrospective study, concerning patients operated for a period of 18 months between September 2018 and February 2020 in the cardiovascular surgery department at the Mohammed V Military teaching hospital in Rabat, and including 253 adult patients.
The bioassay of plasma sodium was done immediately, at 4, 24 and 48 hours after admission to the intensive care unit.
Results: The average age of the patients was 56 years with male predominance. Fifty-seven patients (22.5%) presented at least hypernatremia and 30 patients (11.9%) at least hyponatremia. The overall mortality rate was 7.9%. 17.5% when hypernatremia.
Conclusion: The level of plasma sodium after admission to intensive care is an independent predictor of morbidity and mortality during cardiac surgery under extracorporeal circulation. Hypernatremia is an alarm signal that requires rapid and effective management to avoid progression to serious complications.
Influence of Covid-19 Pandemic on Safe and Timely Delivery of Systemic Anti-Cancer Therapy, Dubai Hospital Experience
Authors: Latif Muhammad Farooq , Tirmazi Syed Hammad , El-Shourbagy Dalia Mahmoud 
Published: December 2022

Aims: To analyze the effect of COVID-19 pandemic on timely delivery of systemic anti-cancer treatment including chemotherapy, biological therapy and immunotherapy and assess complication rate.
Place and Duration of Study: Department of Oncology, Dubai Hospital, Dubai, UAE from January 2020 to July 2020.
Methods: This is a retrospective review of electronic medical records and infusion Centre log of the number of chemotherapy sessions administered in the infusion therapy Centre, Dubai hospital from January 2020 to July 2020. Data on treatment delays, interruptions or discontinuations, and adverse events such as febrile neutropenia were collected and analysed.
Results: A total of 1553 systemic treatment sessions were recorded between January 2020 to July 2020 with an average of 222 treatment sessions per month. Physician recorded delays were observed in ninety (5.79%) treatment sessions. The average treatment delay was 7 (2-13) days. Delays were frequently caused by the overall treatment course and disease-related factors (toxicities, disease progression). The highest number of treatment delays (n=23,10.2%) were recorded in April, at the peak of the Covid-19 pandemic, most likely because of the implementation of extreme precautionary measures. There were no interruptions or discontinuations in treatment.
Fourteen (<1%) patients developed febrile neutropenia. With treatment, all of them recovered fully. No significant change in systemic treatment related complications were observed during the pandemic.
Conclusion: This study found no evidence of an appreciable rise in the number of complications or delays in systemic anticancer treatment during the COVID-19 pandemic. This experience indicates that systemic chemotherapy may be delivered successfully during a pandemic with infection control and safety precautions. However, more research with a larger sample size is needed for more accurate advice in this case.
Association of COVID-19 Vaccination Rates of Staff and COVID-19 Illness and Death Among Residents and Staff in US Nursing Homes
Authors: Sinha Soham , Konetzka R. Tamara 
Published: December 2022

ImportanceIt is important to understand the association between staff vaccination rates and adverse COVID-19 outcomes in nursing homes.ObjectiveTo assess the extent to which staff vaccination was associated with preventing COVID-19 cases and deaths among residents and staff in nursing homes.Design, Setting, and ParticipantsThis longitudinal cohort study used data on COVID-19 outcomes in Medicare- and Medicaid-certified nursing homes in the US between May 30, 2021, and January 30, 2022. Participants included the residents of 15 042 US nursing homes that reported COVID-19 data to the Centers for Disease Control and Prevention and passed Centers for Medicare &amp;amp; Medicaid Services data quality checks in the National Healthcare Safety Network.ExposuresWeekly staff vaccination rates.Main Outcomes and MeasuresMain outcomes are weekly COVID-19 cases and deaths among residents and weekly COVID-19 cases among staff. The treatment variable is the primary 2-dose staff vaccination rate in each facility each week.ResultsIn the primary analysis of 15 042 nursing homes before the Omicron variant wave (May 30 to December 5, 2021) using fixed effects of facility and week, increasing weekly staff vaccination rates by 10 percentage points was associated with 0.13 (95% CI, −0.20 to −0.10) fewer weekly COVID-19 cases per 1000 residents, 0.02 (95% CI, −0.03 to −0.01) fewer weekly COVID-19 deaths per 1000 residents, and 0.03 (95% CI, −0.04 to −0.02) fewer weekly COVID-19 staff cases. In the secondary analysis of the Omicron wave (December 5, 2021, to January 30, 2022), increasing staff vaccination rates were not associated with lower rates of adverse COVID-19 outcomes in nursing homes.Conclusions and RelevanceThe findings of this cohort study suggest that before the Omicron variant wave, increasing staff vaccination rates was associated with lower incidence of COVID-19 cases and deaths among residents and staff in US nursing homes. However, as newer, more infectious and transmissible variants of the virus emerged, the original 2-dose regimen of the COVID-19 vaccine as recommended in December 2020 was no longer associated with lower rates of adverse COVID-19 outcomes in nursing homes. Policy makers may want to consider longer-term policy options to increase the uptake of booster doses among staff in nursing homes.
Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells
Authors: Bignoux Monique J. , Otgaar Tyrone C. , Bernert Martin , Weiss Stefan F. T. , Ferreira Eloise 
Published: December 2022

The incidence and mortality rates of cancer are growing rapidly worldwide, with lung cancer being the most commonly occurring cancer in males. Human carcinomas circumvent the inhibitory pathways induced by DNA damage and senescence through the upregulation of telomerase activity. The 37 kDa/67 kDa laminin receptor (LRP/LR) is a cell surface receptor which plays a role in several cancer hallmarks, including metastasis, angiogenesis, cell viability maintenance, apoptotic evasion, and mediating telomerase activity. We have previously shown that the knockdown of LRP/LR with an LRP‐specific siRNA significantly impedes adhesion and invasion, induces apoptosis, and inhibits telomerase activity in various cancer cell lines in vitro. Here, we investigated the effect of downregulating LRP/LR with LRP‐specific siRNA in A549 lung cancer cells. Downregulation of LRP/LR resulted in a significant decrease in cell viability, migration potential, and telomerase activity, as well as a significant increase in apoptosis. Proteomic analysis further suggested the re‐establishment of immune control over the lung cancer cells, a previously unidentified facet of LRP downregulation in cancer. Altogether, we suggest that targeting LRP/LR for downregulation may have therapeutic potential for inhibiting several cancer hallmarks.
Hyperacute immune responses associate with immediate neuropathology and motor dysfunction in large vessel occlusions
Authors: Farooqui Mudassir , Ortega‐Gutierrez Santiago , Hernandez Katherine , Torres Vanessa O. , Dajles Andres , Zevallos Cynthia B. , Quispe‐Orozco Darko , Mendez‐Ruiz Alan , Manzel Kenneth , Ten Eyck Patrick , Tranel Daniel , Karandikar Nitin J. , Ortega Sterling B. 
Published: December 2022

AbstractObjectiveDespite successful endovascular therapy, a proportion of stroke patients exhibit long‐term functional decline, regardless of the cortical reperfusion. Our objective was to evaluate the early activation of the adaptive immune response and its impact on neurological recovery in patients with large vessel occlusion (LVO).MethodsNineteen (13 females, 6 males) patients with acute LVO were enrolled in a single‐arm prospective cohort study. During endovascular therapy (EVT), blood samples were collected from pre and post‐occlusion, distal femoral artery, and median cubital vein (controls). Cytokines, chemokines, cellular and functional profiles were evaluated with immediate and follow‐up clinical and radiographic parameters, including cognitive performance and functional recovery.ResultsIn the hyperacute phase (within hours), adaptive immune activation was observed in the post‐occlusion intra‐arterial environment (post). Ischemic vascular tissue had a significant increase in T‐cell‐related cytokines, including IFN‐γ and MMP‐9, while GM‐CSF, IL‐17, TNF‐α, IL‐6, MIP‐1a, and MIP‐1b were decreased. Cellularity analysis revealed an increase in inflammatory IL‐17+ and GM‐CSF+ helper T‐cells, while natural killer (NK), monocytes and B‐cells were decreased. A correlation was observed between hypoperfused tissue, infarct volume, inflammatory helper, and cytotoxic T‐cells. Moreover, helper and cytotoxic T‐cells were also significantly increased in patients with improved motor function at 3 months.InterpretationWe provide evidence of the activation of the inflammatory adaptive immune response during the hyperacute phase and the association of pro‐inflammatory cytokines with greater ischemic tissue and worsening recovery after successful reperfusion. Further characterization of these immune pathways is warranted to test selective immunomodulators during the early stages of stroke rehabilitation.
Reconfigurable Electronic Physically Unclonable Functions Based on Organic Thin‐Film Transistors with Multiscale Polycrystalline Entropy for Highly Secure Cryptography Primitives
Authors: Kim Dongyoung , Im Seongil , Kim Danbi , Lee Hanna , Choi Changsoon , Cho Jeong Ho , Ju Hyunsu , Lim Jung Ah 
Published: December 2022

AbstractIn this study, organic thin‐film transistors (OTFTs) are investigated as a promising platform for cost‐effective, reconfigurable, and strong electronic physically unclonable functions (PUFs) for highly secure cryptography primitives. Simple spin‐casting of solution‐processable small‐molecule organic semiconductors forms unique and unclonable fingerprint thin films with randomly distributed polycrystalline structures ranging from nanoscale molecular orientations to microcrystalline orientations, which provides a stochastic entropy source of device‐to‐device variations for OTFT arrays. Blending organic semiconductors with polymer materials is a promising strategy to improve the reliability of OTFT‐based PUFs. Studies on the relationship between the phase‐separated polycrystalline microstructure of organic semiconductor/polymer blend films and PUF characteristics reveal that the 2D mosaic microcrystalline structure of organic semiconductors in the vertically phase‐separated trilayered structure enables the implementation of OTFT‐based PUFs that simultaneously satisfy the requirements of being unclonable and unpredictable, with reliable cryptographic properties. The inherent multiscale randomness of the crystalline structure allows random distribution in OTFT‐based PUFs even with various channel dimensions. The secret bit stream generated from the OTFT‐based PUF developed in this study is reconfigurable by simply changing the gate bias, demonstrating the potential to counter evolving security attack threats.