bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron
Authors: Bordoni Luca , Kristensen Anders , Sardella Donato , Kidmose Hanne , Pohl Layla , Krag Søren , Schiessl Ina Maria 
Published: January 2023

Abstract
Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the underlying mechanisms of failed tubule repair and AKI-CKD-transition are incompletely understood. In this study, we aimed for dynamic tracking of tubule injury and remodeling to understand if focal injury upon AKI may spread over time.
Here we present a novel model of AKI, in which we rendered only half of the kidney ischemic. Using serial intravital 2-photon microscopy and genetic identification of cycling cells, we tracked dynamic tissue remodeling in post- and non-ischemic kidney regions simultaneously and over 3 weeks. Spatial and temporal analysis of cycling cells relative to initial necrotic cell death, demonstrated pronounced injury propagation and expansion into previously uninjured tissue regions, which predicted tubule atrophy with epithelial VCAM-1 expression.
In summary, our longitudinal analysis of tubule injury, remodeling, and fate, provided important novel insights into AKI pathology.
Can photobiomodulation therapy (LASER/LED) associated or not with biomaterials accelerate the process of bone repair the lower limbs of rats? A systematic review study
Authors: Leal Seânia Santos , Costa Davidson Ribeiro , Pessoa Diego Rodrigues , Reis Layla da Costa dos , Carneiro Renata da Silva , Uchôa Valdiléia Teixeira , de Oliveira Rauyris Alencar , Pavinatto Adriana 
Published: January 2023

Abstract
Many studies have investigated the use of synthetic biomaterials or the use of PBMT to improve the bone repair process. However, there is little evidence on the use of these associated techniques. In view of the above, the present study aimed to carry out a systematic review on the effects of the association of photobiomodulation by low-intensity laser and/or diode-emitting light to biomaterials on bone repair. The present study was conducted according to the Preferred Reporting Items for Meta-Analysis (PRISMA) guidelines, as well as using the terms pre-established by the Cochrane Library Collaboration. Electronic searches were performed in the following databases: PubMed/MEDLINE and Science Direct. The search terms used were "bone repair"; "low-level laser therapy"; "photobiomodulation"; "light emitting diode"; "biomaterials"; "bone substitutes"; "in vivo animal studies". SYRCLE (SYStematic Review Center for Laboratory animal Experimentation) was used to analyze the bias of the studies. A total of 506 studies were found based on the descriptors used, 297 were found in PubMed/MedLine and 209 in Science Direct. Analysis of abstracts and methodology of 108 studies was performed and 86 were excluded. Only 22 studies were considered eligible. At the end of this review, it can be verified that the data presented in recent literature show potential to improve the process of bone repair using PBMT together with several types of biomaterials.
Value of Multidetector CT Coronary Artery for diagnosis and risk factors of chronic total occlusion in patients with severe chest pain
Authors: Alshammari Qurain Turki , Almalahi Afnan , Abdelmalik Bushra , Yousif Elgeili , Yousef Mohamed , Alshammari Meshari T , Gameraddin Moawia , Salih Mohammed 
Published: January 2023

Abstract
Background
Differentiating chronic total occlusion (CTO) from subtotal coronary occlusions (STOs) is often challenging to make from coronary angiography. Multidetector computerized tomography (MDCT) is essential in diagnosing and differentiating CTO from STO in symptomatic patients. The study is designed to explore the value of MDCT coronary angiography in discrimination between CTO and STO and assess the risk stratification in patients with severe chest pain.
Methods
This study is a descriptive cross-sectional one conducted from January 2021 to June 2022. A total of fifty patients (29 males, 21 females), ages ranging from (30–80 years), with coronary artery disease CAD) presented to the hospital with severe chest pain and were suspected of having arterial occlusion. They were examined using MDCT angiography.
Results
The prevalence of CAD was higher in males than females (58% vs. 42%). CAD was most prevalent in the age group of 51–60 (34%). Hypertension, DM, and smoking were the most common risk of CTO of coronary arteries. The CT findings of the coronary arteries showed that 27 cases (54%) were occluded entirely, while 23 (46%) were sub-totally occluded. It was shown that coronary artery calcification (CAC) was higher in patients with STO of coronary arteries compared to patients with CTO (26 cases subtotal vs. 20 cases total occlusion). The LAD was occluded in 30% of the patients and subtotal occluded in 20%, while the RCA was occluded in 14% and 18% subtotally occluded in the patients. The LCX was least frequent to occlusion. The Odd adjusted ratio (AOR) showed that diabetic patients had 1.68 increased Odds of having CTO of coronary arteries compared to non-diabetes (AOR = 1.68, 95% CI = .397–7.089), while hypertensive had 1.42 increased odds of having CTO compared to non-hypertensive (AOR = 1.42, 95% CI= (.366-5.474)). Smokers had 2.20 increased Odds of having CTO compared to non-smokers (AOR = 2.20, 95% CI = .461-10.532)
Conclusion
The study concluded that MDCT angiography is reliable and helps differentiate CTO from STO Hypertension, DM, and smoking are the most significant factors for CTO of coronary arteries. MDCT is recommended as a screening imaging tool for CAD symptomatic and asymptomatic populations.
Accurate quantitation of the phenyl group in methylphenyl silicone oils by GPC-UV
Authors: Li Huiru , Kang Yuting , Zhang Baoshan , Wu Jirong , Hua Xilin , Jiang Kezhi 
Published: January 2023

Abstract
The phenyl content is an important quality parameter for phenyl silicone oils, yet its current determination method by 1H NMR is still unsatisfactory due to the potential interference of methylphenylcyclosiloxane or solvents such as toluene and xylene. Herein, a novel method has been developed for the determination of the phenyl content in phenyl silicone oils by gel permeation chromatography-ultraviolet detection (GPC-UV) analysis. Under optimized parameters, the standard curve has been established in the linear range of 5-1000 µg/mL with a squared correlation coefficient of more than 0.999, and a quantification limit of 0.972 µg/mL. The GPC-UV method can easily exclude potential interfering substances, such as methylphenyl cyclosiloxane, toluene or xylene, and various silicone oils. The phenyl content in 9 available phenyl silicone oil samples was determined with a recovery in the range of 84.63%-106.74%. The determined phenyl content of sample H1 by GPC-UV was in good agreement with that (0.603 mg/g) by the 1H-NMR analysis.
Comparison of pathological characteristics in patients with non-alcoholic fatty liver disease under diverse alanine transaminase upper limits of normal
Authors: Yang Hang , Liu Jie , Chen Qingling , Zhao Lili , Li Jia 
Published: January 2023

Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) patients with elevated serum alanine transaminase (ALT) level are more likely to undergo a liver biopsy for evaluating possible nonalcoholic steatohepatitis (NASH) or significant fibrosis.However,patients with normal ALT could also have advanced stages of NAFLD.This study aimed to explore whether using lower ALT upper limit could reduce missed diagnosis of NASH or significant fibrosis in NAFLD patients.
Methods
Two hundred and eighty-one NAFLD patients who underwent liver biopsy were enrolled in this cross-sectional study.Student t test and Mann Whitney U test were used for the comparison;the prediction value was evaluated with receiver operating characteristic curve and restricted cubic spline;multiple logistic regression analysis was used to explore the association.
Results
Among these 281 patients,190 (67.6%) had NASH or significant fibrosis,and had higher ALT [84.00 (43.75,139.50) vs. 39.00 (22.00,64.00) U/L,U = 4872.000,P < 0.001] than Patients without.Using frequently-used ALT upper limit (50 U/L for male and 40 U/L for female) will miss diagnosis 24.7% of NASH or significant fibrosis patients.Using lower ALT upper limit (30 U/L for male and 19 U/L for female) will miss diagnosis 6.3% of patients.
Conclusion
The use of lower ALT upper limit (30 U/L for male and 19 U/L for female) could significantly reduce missed diagnosis of NASH or significant fibrosis.
Inflammatory Myositis Without Borders, Case Report
Authors: Kara Mete , Kara Müge Mercan , Diniz Gülden 
Published: January 2023

Abstract
Idiopathic inflammatory myopathies (IIM) are rare chronic inflammatory diseases whose etiologies are not clearly known, which particularly involve muscles, and which can also affect many other organs. There are many subgroups of inflammatory myositis under the roof of IIM, and there are intermediate form cases which do not comply with these.
A 85-year-old female patient presented to our clinic with the complaints of prevalent muscle pain that started 15 days ago and increased progressively, weakness in arms and legs, and difficulty to swallow. Muscle biopsy was performed in the patient whose elevated muscle enzymes and electromyography and magnetic resonance imaging (MRI) findings were consistent with inflammatory myositis. Although the histopathological examination of muscle biopsy was consistent with inflammatory myositis, it did not completely comply with any of the known forms. As the patient’s dysphagia increased and aphonia developed in the follow-up, pulse steroid, intravenous immune globulin, and azathioprine treatment in the aftermath was started. In the posttreatment 24th month, the case is being followed up in remission.
Differential diagnosis of myopathies includes infection, malignance, drug use, autoimmune diseases, IIM, etc. Although our knowledge of IIM is increasing, a final diagnosis could not be established for some cases with clinical symptoms, laboratory tests, MRI, and even with biopsy. As in our case, there may be cases which do not comply with IIM subgroup boundaries, and new research is needed for the clarification of these boundaries.
Model-based clustering of multiple networks with a hierarchical algorithm
Authors: Rebafka Tabea 
Published: January 2023

Abstract
The paper tackles the problem of clustering multiple networks, that do not share the same set of vertices, into groups of networks with similar topology. A statistical model-based approach based on a finite mixture of stochastic block models is proposed. A clustering is obtained by maximizing the integrated classification likelihood criterion. This is done by a hierarchical agglomerative algorithm, that starts from singleton clusters and successively merges clusters of networks. As such, a sequence of nested clusterings is computed that can be represented by a dendrogram providing valuable insights on the collection of networks. Using a Bayesian framework, model selection is performed in an automated way since the algorithm stops when the best number of clusters is attained. The algorithm is computationally efficient, when carefully implemented. The aggregation of clusters requires a means to overcome the label-switching problem of the stochastic block model and to match the block labels of the networks. To address this problem, a new tool is proposed based on a comparison of the graphons of the associated stochastic block models. The clustering approach is assessed on synthetic data. An application to a set of ecological networks illustrates the interpretability of the obtained results.
Comparison of three-dimensional reconstruction and CT-guided hook-wire segmental resection for pulmonary nodules: a propensity score matching study
Authors: Hong Ziqiang , Sheng Yannan , Cui Baiqiang , Bai Xiangdou , Huang Daxin , Lu Yingjie , Cheng Tao , Jin Dacheng , Gou Yunjiu 
Published: January 2023

Abstract
perioperative deaths. After PSM, 79 patients were successfully matched in each of the two groups. Two cases of pneumothorax, three cases of hemothorax and four cases of decoupling occurred in the Hook-wire group; no complications of pneumothorax, hemothorax and decoupling occurred in the 3D reconstruction group. Compared with the Hook-wire group, the 3D reconstruction group had shorter operative time
Objective: To analyze and compare the clinical application value of three-dimensional reconstruction and CT-guided Hook-wire localization row lung segment resection for pulmonary nodules.
Methods: Retrospective analysis of the clinical data of 204 patients with pulmonary nodules admitted to the Department of Thoracic Surgery of Gansu Provincial People's Hospital from June 2016 to December 2022. The group was divided into a 3D reconstruction group (98 cases) and a Hook-wire group (106 cases) according to the preoperative positioning method. The two groups of patients were propensity score matching(PSM) to compare the perioperative outcomes of patients in both groups.
Results: All patients in both groups completed the surgery successfully with no perioperative deaths. After PSM, 79 patients were successfully matched in each of the two groups. Two cases of pneumothorax, three cases of hemothorax and four cases of decoupling occurred in the Hook-wire group; no complications of pneumothorax, hemothorax and decoupling occurred in the 3D reconstruction group. Compared with the Hook-wire group, the 3D reconstruction group had shorter operative time (P=0.001), less intraoperative bleeding (P<0.001), and shorter postoperative hospital stay (P=0.026), and there was no statistically significant difference between the two groups in terms of pathological type and TNM staging (P=0.316).
Conclusion: Pulmonary nodules are based on three-dimensional reconstruction and localization, and individualized thoracoscopic anatomical lung segment resection is safe and effective with a low complication rate, which has good clinical application value.
Identifying Cutaneous Leishmaniasis Vectors after an Outbreak: Anthropophily of Sergentomyia species and detection of Leishmania major DNA within Sergentomyia ingrami, in Ghana
Authors: de Souza Dziedzom K. , Desewu Kwame , Nzelu Chukwunonso O. , Addo Seth Offei , Mosore Mba T. , Odoom Shirley , Puplampu-Attram Naiki , Appawu Maxwell , Wilson Michael D. , Boakye Daniel A. 
Published: January 2023

Abstract
Prior to 1999, Ghana was not known to be a Cutaneous Leishmaniasis (CL) endemic country. The outbreak of CL in the Volta Region in 1999 resulted in the need for urgent investigations to understand the disease transmission dynamics. Monthly entomological collections from January 2006 to May 2007 revealed 99.8% (21,980/22,016) of sand flies collected were Sergentomyia and 0.2% (36/22,016) Phlebotomus, the putative vector of CL in the Old World. The density of Phlebotomus was so low, their vectorial role is uncertain. This study was therefore aimed at determining the possible vector species in the outbreak area. We collected sand flies from homes to examine anthropophily, by testing their blood meals. The blood-meal sources of 275 (20.5%) of 1342 collected female sand flies revealed the highest proportion of animal blood source was chicken (33.8%) and goat (12.4%). Humans accounted for 32% of blood meal sources. Identified species included: Sergentomyia africana africana (26.9%), S. ingrami (34.5%) and S. simillima (38.2%), which were found to have single and mixed blood-meals, with S. simillima having the highest proportion that contained human blood (14.6%). Using molecular methods, we examined unfed flies and flies found anthropophilic for the presence of Leishmania major DNA. Poolscreening analysis revealed 3 pools of S. ingrami positive with L. major DNA, with an infection rate of 1.27% (95% confidence interval: 2.467–3.647). This study showed that some Sergentomyia species are anthropophilic, contain L. major DNA, and could be involved in the transmission of CL in Ghana. There is however the need to conclusively validate the role of S. ingrami as a vector of L. major in Ghana, by isolating the parasite and initiating experimental transmission studies.
Sexuality education is key to addressing adolescent pregnancies in Tanzania; a cross-sectional study and content analysis of vital national reports
Authors: Chuwa Agapiti Hipoliti 
Published: January 2023

Abstract
Background
Tanzania is among the countries with higher rates of adolescent pregnancy. In some parts of the country, 45% of teenage girls become pregnant before their nineteenth birthday; and the strategies to alleviate the situation remain partially understood. The current study aimed to assess the knowledge level of adolescents on sexuality issues and the factors contributing to teenage pregnancy, as well as the progress made by Tanzania in addressing this problem.
Methods
A cross-sectional study was carried out on students from four randomly selected secondary schools in Morogoro municipality; an area with a high rate of adolescent pregnancy in Tanzania. Data were collected using structured questionnaires. Qualitative data from the study and data from the Demographic Health Surveys and Household Budget Surveys were analyzed by content analysis.
Results
Among the 250 respondents, 83.6% (n = 209) were in the age group 13–18 years and the rest (16.4%) were 19 + years. Most (96%, n = 240) mentioned that adolescent pregnancy is more common in poor societies, and 73.6% (n = 190) cited a lack of knowledge of reproductive health as a major contributing factor. More than 55% did not know any other method of contraception, apart from a male condom. Only 41.6% of female and 18.8% of male respondents correctly knew about the day of ovulation. From content analysis, it was revealed that girls’ enrolment declines from 50% of the total in primary education to 30% of the total students’ enrolment in colleges and universities. The overall teenage pregnancy rate in the country increased by 4 percentage points; from 23% in 2010 to 27% in 2016.
Conclusions
Adolescent girls in Tanzania are less empowered because they lack comprehensive sexuality education, hence, the higher rates of adolescent pregnancy. Introducing age-appropriate sexuality education and increasing girls’ enrolment in secondary and tertiary education will significantly reduce the rate of teenage pregnancy.
Intraoperative challenges and outcomes of pediatric cataract surgery following glaucoma filtering surgery
Authors: Badakere Akshay , Badakere Swathi Vallabh , Aijaz Syed Khaleeluddin , Gupta Neha , Kekunnaya Ramesh , Senthil Sirisha 
Published: January 2023

Abstract
Purpose- To analyze the intraoperative challenges of cataract surgery in children, following glaucoma filtering surgery.
Methods- This was a retrospective study to analyze intra-op challenges and outcomes of pediatric cataract surgery in post-glaucoma filtration surgery eyes, between January 2007 to December 2019.
Results- We included 20 eyes of 16 children. The most common glaucoma surgery performed was trabeculectomy and trabeculotomy (14 eyes). The median age at the time of cataract surgery was 74.5 months. The most common cataract surgery performed was lens aspiration with posterior chamber intraocular lens implantation (LA+PCIOL) (9/20). The most common intraoperative challenge faced was difficulty in capsulorrhexis (10 eyes), followed by extension of primary posterior capsulotomy (6 eyes). At the final follow up 8 eyes had improvement in visual acuity, 5 eyes had stable visual acuity and 5 eyes had a drop in visual acuity. In 12/20 eyes IOL was implanted, 9 eyes in-the-bag and 3 eyes had in ciliary sulcus. None of the IOLs in the bag had decentration of IOL. The median postoperative IOP (p=0.12) and median number of postoperative AGM (p=0.13) at 2 years remained stable compared to the preoperative values. The IOP remained well controlled in 4 eyes without anti-glaucoma medications and in 14 eyes with anti-glaucoma medications and none needed additional surgery for IOP control. Two eyes developed retinal detachment postoperatively.
Conclusion- Cataract surgery in pediatric eyes with prior glaucoma surgeries, have challenges with capsulorrhexis and IOL stability. The visual outcomes were reasonably good so was the IOP control.
Cross-Religious Rituals in the Moluccas, Indonesia
Authors: Ridwan M. , Sulaeman Sulaeman , Nurdin Ali , Hadawiah Hadawiah , Mustafa Irvan , Busro Busro 
Published: January 2023

Abstract
The cross-religious communities (Muslim-Christian communities) in the Moluccas, Indonesia, have various local traditions manifested by kinship ties. Kinship values have become a model for identity in building harmonious relationships. This study examines the reasons for Muslim communities’ involvement in rituals carried out by Immanuel Church. The data were obtained qualitatively through several informal conversational interviews from the perspective of the ritual process (Turner 1962,1969), and phenomenology (Schutz, 1972). The study finds that involvement begins with taking the “pela” oath as part of the Muslim community and participation in the cross-religious pela gandong through traditional values based on kinship, diversity, equality, and togetherness. To assert self-identity, cross-religious communities engage in traditional rituals (tambourine–totobuang collaboration, using gandong cloth, lesso dancing, and eating patita) and religious rituals (chanting of the call to prayer and Rawi barzanji). The subjective experience of cross-religious ritual involvement includes ignorance, traps, encounters and relationships, and acceptance of diversity. Participants are motivated by the goals of self-identity proof and kinship search for the meaning of theological pluralism, which allows peaceful coexistence through cross-religious civic pluralism. This study contributes to realizing cross-religious harmonization through discussing the search for religious meaning in the hopes of making it possible to live together peacefully through kinship ties. Strengthening kinship is very important because it tends to lower incidences of cross-religious conflict. This contribution offers religious accommodation opportunities and ways to avoid cross-religious tensions.