bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative approach applications for groundwater management at the Ajmer division
Authors: Phulpagar Sanju Ramesh , Kale Ganesh D. 
Published: December 2022

Abstract
For proper management of groundwater (GW) resources, appropriate management strategies are necessary. It is essential to know where and why these management strategies need to be applied. For this prioritization of GW blocks and identification of factors affecting declining trends in GW are essential and for addressing these issues, two innovative approaches are applied in the present study. In the first approach, prioritization of GW blocks is performed by employing trend analysis in seasonal groundwater levels (GWLs) while identification of factors affecting declining trends in GW is performed in second approach by analyzing trends in climatic parameters, namely MNTEMP and rainfall (RF). Stage of GW development in most of the blocks in districts of the Ajmer division has already exceeded 100%, which indicated that the scope of GW development is already exhausted. Thus, in the present study, aforesaid approaches are applied at every block in districts of the Ajmer division for proper management of GW resources. Results showed that, in some blocks, GW is found to be significantly declining due to significantly incrementing MNTEMP and declining RF. Also, GW is found to be declining due to declining RF at few blocks and due to significantly incrementing MNTEMP at some blocks in districts of the Ajmer division.
Turismo religioso e os impactos do COVID-19 no setor de bares e restaurantes de São José de Ribamar - MA
Authors: Soares Maria , Rodrigues de Sousa Lucyane , Guedes Cutrim Kláutenys Dellene 
Published: December 2022

RESUMO
O turismo religioso é um segmento crescente ligado ao calendário de eventos do país, um fenômeno social que por meio dos deslocamentos a festas e espaços religiosos, reúne multidões, adeptos que se utilizam do tripé turístico: transporte, hospedagem e alimentação, proporcionando desenvolvimento econômico as localidades com a geração de emprego e renda. No entanto, a pandemia do COVID-19, a mais severa crise sanitária dos últimos tempos e a necessidade de medidas como isolamento social para conter a disseminação do vírus causaram um profundo impacto a economia mundial, sendo o turismo o setor mais impactado. Nesse sentido, este artigo que é parte final da pesquisa realizada durante a pandemia em São José de Ribamar, cidade conhecida pela cultura religiosa, tem como objetivo apresentar um estudo acerca dos impactos da pandemia no setor de bares e restaurantes. Para tanto, fez-se pesquisa bibliográfica e de campo onde utilizou-se instrumento de questionário sendo aplicado junto aos donos dos empreendimentos que fazem parte do setor turístico que mais fechou postos de trabalho no Brasil, de acordo com o Relatório de Impacto do Ministério do Turismo (2020). A pesquisa foi realizada na cidade em setembro de 2021, durante o festejo de São José de Ribamar, o qual teve parte realizado virtualmente, sem romarias nem procissões. Para os resultados, aponta-se a ausência em maior parte dos empreendimentos, em relação ao uso de mídias digitais para divulgação de produtos e serviços, descontentamento com medidas governamentais, endividamento e melhora com o retorno às atividades, ainda que de forma regular.

Palavras-chave: Turismo Religioso. Covid-19. Bares e Restaurantes. Festejo de São José de Ribamar.
Vulnerabilidade Social da Cidade de Teresina, Piauí
Authors: Chaves Sammya Vanessa Vieira , Santos Laudenides  Pontes dos , Santos Francílio de Amorim dos , Vieira Valdira de Caldas Brito , Dantas Felipe Ramos 
Published: December 2022

A ocupação desordenada das cidades brasileiras tem aumentado o número de pessoas afetadas por inundações, e a ocupação do leito maior dos rios urbanos por populações pobres tem contribuído para a agudização dos danos gerados. Estudos de vulnerabilidade socioambiental têm se tornado valioso instrumento na busca da mitigação dos efeitos das inundações, uma vez que aglutinam indicadores sociais, econômicos e ambientais, revelando a capacidade de resposta dos afetados para o enfrentamento dos desastres. Desse modo, objetivou-se, com o presente estudo, analisar a vulnerabilidade socioambiental de Teresina, Piauí, às recorrentes inundações. Para tanto, foram utilizados dados alfanuméricos de 11 variáveis, agrupadas em 4 critérios: demografia, educação, renda e condições habitacionais, para os 110 bairros do município de Teresina. A equação do índice de vulnerabilidade socioambiental (IVSA) para o município de Teresina se baseou em média aritmética simples. Os dados refinados das 11 variáveis e IVSA foram espacializados via ferramentas do QGIS. Constatou-se que os bairros Itararé, Angelim, Santo Antônio, Promorar e Mocambinho são os mais vulneráveis às inundações em Teresina, pois apresentaram baixos índices nas dimensões avaliadas, tornando essencial a intervenção do poder público sobre os mesmos, com o intuito de aumentar a capacidade de resposta mediante a materialização do desastre.
Palavras-Chave: Vulnerabilidade. Inundação. Teresina.
Novel Nanotechnological Strategies for Skin Anti-aging
Authors: Domínguez-Delgado Clara Luisa , Pozos-Nonato Sara , Campos-Santander Kenia Areli , Benavides Allyson Amelia , Pacheco-Ortin Sandy María , Higuera-Piedrahita Rosa Isabel , Resendiz-González Guillermo , Molina-Trinidad Eva María 
Published: December 2022

Background:Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/ molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research.Objective:Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work.Method:The information in this review was extracted from recent and relevant studies using nanotechnology for anti-aging treatment from scientific databases.Results and Discussion:Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes, niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as, flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin, silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic, rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin, botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability, and effectivity for skin anti-aging, providing a controlled drug release with minimized side effects.Conclusion:Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles, enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin. Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the clinic/industry.
Monitoring Shrimp Spoilage Using a Paper-based Colorimetric Label
Containing Roselle Flower Extract
Authors: Fauzia Vivi , Listyarini Arie , Imawan Cuk , Djuhana Dede 
Published: December 2022

Background:
Intelligent food packaging that can monitor food quality and safety is
essential in modern commercial trade. Research on the fabrication of environmentally friendly
colorimetric labels that can indicate the freshness of food through color changes are needed.

Methods:
In this study, paper-based colorimetric labels were prepared using filter paper dipped
into a solution of Roselle flower extract, and their performance in monitoring shrimp spoilage
was investigated.

Results:
The labels’ response to ammonia vapor shows a distinct color variation from red to
greenish-grey, corresponding to a sharp increase in the total color difference (ΔE = 32). The labels
are relatively stable during storage at 4°C for up to 20 days. In shrimp freshness monitoring,
the color changes from red to purple, which corresponds to increasing levels of total volatile
basic nitrogen (TVB-N), and can be observed easily with the naked eye.

Conclusion:
This suggests that our paper-based colorimetric labels impregnated with Roselle
extract show superior performance in detecting shrimp spoilage.
Diagnosis and Management of Supine and Nocturnal Hypertension in
Orthostatic Hypotension: A Review
Authors: Aravinthan Prassana , Aravinthan Trilochan , Anpalahan Aksharaa , Anpalahan Mahesan 
Published: December 2022

Abstract:
The prevalence of supine and nocturnal hypertension (S-N-HT) is high among patients
with orthostatic hypotension (OH), especially in those who have a neurogenic aetiology.
The evidence suggests that S-N-HT exacerbates OH, although it is unclear whether pharmacologic
treatment of S-N-HT will improve OH. S-N-HT has also been associated with target organ
damage. Therefore, assessment and management of S-N-HT should be an integral part of
managing OH, but it is often overlooked in clinical practice.
Metabolomics-based Approach to Analyze the Therapeutic Targets and
Metabolites of a Synovitis Ointment for Knee Osteoarthritis
Authors: Zhang Lei , Yang Huan , Liu Jing , Wang Ke , Cai Xiang , Xiao Wei , Wang Le , Wang Mang , Zhang Chi , Zhang Jin 
Published: December 2022

Background:
Knee osteoarthritis (KOA) is a clinically common degenerative joint disease
that is not fatal but has a high prevalence. Synovitis ointment (HMYG) is a traditional Chinese medicine
formula that has been clinically proven to treat KOA; however, its therapeutic targets remain unknown.

Objective:
This study aimed to identify metabolites and potential targets of synovitis ointment alleviation
in rats with KOA using ultra-high-performance liquid-chromatography–mass spectrometry
(UHPLC-MS) metabolomics.

Methods:
The meniscus on each side of the knee was removed to model KOA in rats. The synovitis
ointment treatment was provided for 4 weeks. The lateral diameter of the knee was measured once a
week, and after 4 weeks, serum was collected to observe changes in the knee through a metabolomic
analysis.

Results:
Synovitis ointment reduced the lateral diameter of the knee joint, relieved knee swelling, and
improved knee volume. In total, 28 differential metabolites, which were mainly involved in arginine
and proline metabolism and apoptosis, were identified in the Con and HMYG groups. 15-Deoxy-d-12,
14-PGJ2 and fomepizole were found to be the key metabolites after the HMYG treatment of KOA.
Compared with known drugs (diclofenac diethylamine emulsion and Jin Huang San), 2-(SGlutathionyl)
acetyl glutathione, daidzein, pelargonic acid, and sulfamethoxazole increased in the
HMYG, and the metabolic pathways included the oxytocin signaling pathway, platelet activation, olfactory
transduction, phototransduction, and cGMP-PKG signaling pathway. The expression levels of
cleaved-caspase-3, Bcl-2, PIK3a, TP53, TGFB1, and NFKB1 were reversed after HMYG treatment.

Conclusion:
It has been observed that synovitis ointment relieves KOA. UHPLC-MS can analyze the
potential mechanism of action of the herbal compound of the synovitis ointment.
Signalling Pathways Involved in Microglial Activation in Alzheimer’s
Disease and Potential Neuroprotective Role of Phytoconstituents
Authors: Ali Mohd Uzair , Anwar Laiba , Ali Mohd Humair , Iqubal Mohammad Kashif , Iqubal Ashif , Baboota Sanjula , Ali Javed 
Published: December 2022

Abstract:
Alzheimer’s disease (AD) is a commonly reported neurodegenerative disorder associated
with dementia and cognitive impairment. The pathophysiology of AD comprises Aβ, hyperphosphorylated
tau protein formation, abrupt cholinergic cascade, oxidative stress, neuronal apoptosis, and neuroinflammation.
Recent findings have established the profound role of immunological dysfunction and
microglial activation in the pathogenesis of AD. Microglial activation is a multifactorial cascade encompassing
various signalling molecules and pathways such as Nrf2/NLRP3/NF-kB/p38 MAPKs/
GSK-3β. Additionally, deposited Aβ or tau protein triggers microglial activation and accelerates its
pathogenesis. Currently, the FDA-approved therapeutic regimens are based on the modulation of the
cholinergic system, and recently, one more drug, aducanumab, has been approved by the FDA. On the
one hand, these drugs only offer symptomatic relief and not a cure for AD. Additionally, no targetedbased
microglial medicines are available for treating and managing AD. On the other hand, various
natural products have been explored for the possible anti-Alzheimer effect via targeting microglial activation
or different targets of microglial activation. Therefore, the present review focuses on exploring
the mechanism and associated signalling related to microglial activation and a detailed description of
various natural products that have previously been reported with anti-Alzheimer’s effect via mitigation
of microglial activation. Additionally, we have discussed the various patents and clinical trials related
to managing and treating AD.
Histopathological Findings of Oral Mucosa in Smokeless Tobacco Users: Case Report
Authors: Miļuna Sintija , Melderis Ričards , Sperga Māris , Skadiņš Ingus , Kroiča Juta , Rostoka Dagnija 
Published: December 2022

Background:
New tobacco products, such as smokeless tobacco, are becoming more popular every year. In talking with our patients, we determined several reasons for that trend. The sale of these products is prohibited in many countries; hence, people obtain the product illegally. This is important, since when these products are stored under inappropriate conditions and temperatures, the quality and properties of the product change, including their carcinogenic properties. Sometimes people use a lot of this product or more than one tobacco product daily. It is challenging for dental practitioners to question their patients about tobacco consumption and more challenging to visually detect oral mucosal changes, because patients usually do not have concerns or they do not pay attention.

Methods:
In the two cases presented here, the patients did not have any pain, nor did they notice when the lesions appeared. These patients used conventional cigarettes for some time and then switched to smokeless tobacco due to relocation to Latvia. Soft tissue excision was performed and sent for histopathological examination.

Results:
The findings were proliferation of oral epithelial cells from buccal region, their overgrowth, an excessive amount of fibroblasts, cell destruction and necrosis, and a large amount of inflammatory cells, eosinophil leukocytes, and plasma cells.

Conclusion:
We can conclude that these intraoral findings are important risk factors for possibly developing precancerous lesions. Such mucosal changes can occur with different forms of tobacco, including Swedish snus and betel leaves. Dental practitioners should always question patients about tobacco use and regularly check for mucosal changes for early detection.
Thoracolumbar Interfascial Plane Block (TLIP) Modified Technique for Lumbar Decompression Surgery in Cirrhotic Hepatic Patients with Thrombocytopenia: A Case Report
Authors: Tantri Aida Rosita , Natali Christella , Soebroto Erlina , Ferdiana Komang Ayu 
Published: December 2022

Introduction:
As one of the top ranks in the pain-producing procedure, spinal surgery requires adequate perioperative pain management to improve outcomes. Likewise, perioperative pain management in cirrhotic hepatic thrombocytopenia patients is challenging. Modified TLIP block can be an option for perioperative pain management in the lumbar decompression surgery for a cirrhotic hepatic patient with thrombocytopenia.

Case Presentation:
A man, 67 years old, who suffered from cirrhosis hepatic with thrombocytopenia underwent endoscopic spinal decompression with laminotomy and flavectomy of L4-L5. After induction of general anesthesia with midazolam 1,5 mg, fentanyl 150 mcg, propofol 100 mg, and rocuronium 1mg/kg, the patient was intubated. The lungs were ventilated with a pressure control mode with tidal volume 8 ml/kg BW, respiratory rate 12/min, and PEEP 5 cm H2O with FiO2 50%. and 1% sevoflurane. Modified TLIP block was performed at the L3 level. Twenty ml of bupivacaine 0,5% was administered between the longissimus and iliocostalis muscles on both sides.

Results:
Intraoperative, modified TLIP block provide adequate analgesia with stable hemodynamics. The visual Analog Scale (VAS) of pain was 1-2 in 24h postoperative. No additional opioid was required within 24 hours postoperatively. There were no neurological complications or bleeding due to the modified TLIP block found in this patient.

Conclusion:
Modified TLIP block can be an effective and safe analgesic technique for hepatic cirrhosis patients with thrombocytopenia. However, further research is needed to determine the safety limits of modified TLIP block in patients with coagulation disorder or anticoagulant use.
Relationship between the Prevalence of Glaucoma (Estimated Through Prescribed Antiglaucomatous Medication) and Access to Ophthalmologists in Norway
Authors: Slettedal Jon Klokk , Traustadóttir Valgerður Dóra , Sandvik Leiv , Ringvold Amund 
Published: December 2022

Purpose
The relationship between supply and demand in health-care is a challenge. The purpose of the present study is to evaluate to what extent glaucoma prevalence is influenced by local access to eye health-care service in Norway.

Methods
Population-based cross-sectional study. Data from The Norwegian Prescription Database was used to find the number of users of topical glaucoma medication, grouped by age and county, giving an estimate of glaucoma prevalence. The number of registered ophthalmologists and opticians was obtained from The Norwegian Society of Ophthalmologists and The Norwegian Directorate of Health.

Results
In total, 75733 persons were treated with IOP-lowering drugs in Norway in 2018, suggesting an overall glaucoma prevalence of 1.43%. In the age group 70-89 years, the nationwide prevalence was 7.60%, the lowest prevalence being in Oppland (5.98%) and highest in Aust-Agder (9.28%) counties. The number of ophthalmologists per 100000 inhabitants varied from 2.63 to 14.65 in the various counties. A statistically significant correlation was found between glaucoma prevalence in the age group 70-89 years and access to ophthalmological services. Furthermore, the increase in glaucoma prevalence plateaus at roughly 10 ophthalmologists per 100000 inhabitants, indicating that this could cover population demands. This relationship did not apply for opticians.

Conclusions
There is a clear correlation between glaucoma prevalence and availability of ophthalmologists in various counties in Norway. Our study indicates a direct relationship between the number of ophthalmologists in the area and the number of people being treated for glaucoma, with prevalence plateauing once a threshold of approximately 10 ophthalmologists per 100000 inhabitants is reached. This finding suggests that low glaucoma prevalence in some regions could be due to limited access to ophthalmological services.
High Prevalence of Lower Extremity Medial Arterial Calcification in HIV-infected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study
Authors: Višković Klaudija , Marinelli Annibale , Nedeljko Katrin , Bržan Petra Povalej , Bogdanić Nikolina , Begovac Josip 
Published: December 2022

Background:
The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown.

Objective:
We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group.

Methods:
MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73m2 and 25 with an eGFR <60 mL/min/1.73m2) and 141 HIV-uninfected patients (68 with eGFR<60 ml/min/1.73m2).

Results:
MAC was most frequently found in PLWH with CKD (76%). The prevalence of MAC among PLWH was 54.0% (95% confidence interval [CI], 40.4-67.0%), whereas, in HIV-uninfected, it was 34.0% (95% CI, 26.7-42.2%, P=0.013). Age and CKD were consistently associated with MAC in our multivariable models, and there was also a sign that PLWH had higher odds of having MAC.

Conclusion:
We found a higher prevalence of MAC in PAD-asymptomatic PLWH compared to HIV-uninfected ones and provided evidence that HIV infection could be associated with MAC.
Management of Mental Health Problem among Primary School Teachers using Rational-emotive Behavior Therapy
Authors: Ugwuanyi Christian S. 
Published: December 2022

Background:
Teachers in the Nigerian education system, especially at the primary level, experience various mental health issues. This is likely to be so as primary school teachers carry out a lot of responsibilities ranging from teaching all the primary school subjects to taking care of their families. Studies have revealed that mental health issues limit the academic responsibilities of teachers. However, there is a dearth of literature on mental health issues management among primary school teachers.

Objective:
This study explored the effect of rational-emotive behavior therapy (REBT) on work stress management among primary school teachers.

Methods:
Using a randomised control trial group experimental design, this research used 45 primary school teachers as the study participants. Data for the study were collected using a work stress questionnaire which was properly validated and trial tested (α = .84). The participants were pretested before being exposed to a 12-week REBT intervention treatment. Participants were then retested and received follow-up care two months after the end of the intervention. Data collected were analysed using mixed-design repeated analysis of variance.

Results:
It was revealed that the work stress of the primary school teachers who were exposed to REBT intervention significantly (p < .05) reduced after the treatment.

Conclusion:
REBT intervention significantly affected work stress management among primary school teachers. Therefore, it was recommended that REBT intervention be used as a workplace stress management intervention among primary school teachers.