bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 Detection and COVID-19 Diagnosis: A Bird’s Eye View
Authors: Alzahrani Abdullah R. , Jabeen Qaiser , Shahid Imran , Al-Ghamdi Saeed S. , Shahzad Naiyer , Rehman Sidra , Algarni Alanood S. , Bamagous Ghazi A. , AlanazI Ibrahim Mufadhi M. , Ibrahim Ibrahim Abdel Aziz 
Published: April 2023

Abstract:
The battle against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
associated coronavirus disease 2019 (COVID-19) is continued worldwide by administering firsttime
emergency authorized novel mRNA-based and conventional vector-antigen-based anti-
COVID-19 vaccines to prevent further transmission of the virus as well as to reduce the severe
respiratory complications of the infection in infected individuals. However; the emergence of
numerous SARS-CoV-2 variants is of concern, and the identification of certain breakthrough and
reinfection cases in vaccinated individuals as well as new cases soaring in some low-to-middle
income countries (LMICs) and even in some resource-replete nations have raised concerns that
only vaccine jabs would not be sufficient to control and vanquishing the pandemic. Lack of
screening for asymptomatic COVID-19-infected subjects and inefficient management of diagnosed
COVID-19 infections also pose some concerns and the need to fill the gaps among policies and
strategies to reduce the pandemic in hospitals, healthcare services, and the general community. For
this purpose, the development and deployment of rapid screening and diagnostic procedures are
prerequisites in premises with high infection rates as well as to screen mass unaffected COVID-19
populations. Novel methods of variant identification and genome surveillance studies would be an
asset to minimize virus transmission and infection severity. The proposition of this pragmatic
review explores current paradigms for the screening of SARS-CoV-2 variants, identification, and
diagnosis of COVID-19 infection, and insights into the late-stage development of new methods to
better understand virus super spread variants and genome surveillance studies to predict pandemic
trajectories.
The Activity of Several Medicinal Herbs such as Anti-inflammatories, Anti-
Pyretic, Analgesics and Antioxidants
Authors: Dangi Neha , Sharma Shikha , Goyal Praveen , Govindasamy Jeyabalan 
Published: April 2023

Background:
People have been using different plants to treat a wide variety of illnesses ever since the dawn of human civilisation, medicinal plants have been employed. According to the World Health Organization, approximately 80% of people living in developing countries lack the financial means to purchase synthetic drugs. As a result, these individuals turn to traditional medicines, the majority of which are derived from plants, to satisfy their fundamental requirements for health care. Plants have been used as medicine from the beginning of time to cure a broad variety of ailments, including gastrointestinal disorders, genitourinary problems, hepatobiliary discomfort, as well as psychiatric and respiratory issues.

Methods:
In order to get the necessary data, the procedure involves scouring multiple search engines, such as PubMed, ScienceDirect, and Sci Finder, for citations that pertain to the topic at hand. Regarding anti-inflammatories, anti-pyretic, analgesics, and antioxidants.

Results:
For a considerable amount of time, many different plants have been used as a treatment for fever, and recent scientific research has demonstrated that these treatments reduce the temperature of the human body. The significance of medicinal plants as a kind of treatment for fever is brought into sharp focus by this analysis.

Conclusion:
This review can also assist researchers and scientists in locating new antioxidants, antipyretic compounds, and plants that have been utilized for a considerable amount of time.
Herbs Used for the Management of Hypertension: A Systematic Review
Authors: Wan Zairullah Wan Nur Arina Athilah , Fauzi Nur Yuhaniz Mohd , Jofrry Suhaidah Mohd , Fahrni Mathumalar Loganathan , Ming Long Chiau , Choo Chee Yan 
Published: April 2023

Background:
Hypertension is characterized by persistent high blood pressure and has emerged as a critical risk factor for severe cardiovascular diseases. Although several drugs have been designated to reduce blood pressure, these drugs can potentially cause side effects for patients. Therefore, medicinal plants are used to complement conventional drugs to treat various ailments.

Methods:
This study reviews the anti-hypertensive potential of herbs and plants and their mechanism of action in reducing blood pressure at their evaluated effective doses. Databases such as PubMed, Scopus, Science Direct, and Google Scholar were used to search articles from January 2016 to Sept 2022. The key search terms included “hypertension”, “lowers blood pressure”, “anti-hypertensive”, and “plants”. These generated 807 documents and using the PRISMA guidelines, thirty plants were identified for this review. Research studies with similar plant parts extracted from similar solvents, more than one dose, and animal models with a positive control were considered in this review. Studies that did not show significant blood pressure reduction were excluded.

Results:
Based on this criterion, the mechanism of actions of these plants was thematically grouped into three categories, namely 1) antioxidant, 2) angiotensin-converting enzyme (ACE) inhibition, and 3) calcium influx in vascular smooth muscle. The effective doses, plant parts used, and traditional medicine usage are presented in this review.

Conclusion:
Further research is highly recommended to identify the active compounds and to potentially develop them into anti-hypertensive drugs as well as to establish the safe doses and standardization of these plant extracts. This review is partially funded by grants from the Ministry of Higher Education.
Kemampuan membaca Alquran mahasiswa Fakultas Ilmu Sosial Universitas Negeri Yogyakarta
Authors: Sudrajat Ajat 
Published: April 2023

Sering dinyatakan oleh para tutor mata kuliah Pendidikan Agama Islam, bahwa mahasiswa baru UNY memiliki kemampuan membaca Alquran yang rendah. Mereka menyatakan bahwa mahasiswa baru UNY, dari tahun ke tahun, dalam membaca Alquran masih banyak yang ‘gagap’ atau tidak lancar. Oleh karena itu, penelitian ini bertujuan untuk mengetahui kemampuan membaca Alquran mahasiswa baru FIS UNY pada semester genap angkatan tahun akademik 2020/2021. Penelitian ini menggunakan data pelaksanaan tutorial mata kuliah Pendidikan Agama Islam angkatan 2020/2021. Pelaksanaan penelitian dilakukan dengan menggunakan survey yang bersifat populatif, artinya menghitung semua mahasiswa yang ikut tutotial mata kuliah Pendidikan Agama Islam pada tahun akademik 2020/2021. Hasil penelitian menunjukkan bahwa sebagian besar mahasiswa baru FIS UNY tahun akademik 2020/2021masih berada pada jilid dua, yaitu bacaan antar huruf terputus-putus dan salah dalam pelantunan harakat (fathah, kasrah, dhummah, dantanwin) atau tertukar. Sedangkan pada akhir semester terjadi peningkatan, yaitu kebanyakan masuk ke jilid tiga dan empat, bahkan lima, mencapai 74%.It is often stated by tutors of Islamic Religious Education courses, that new UNY students have poor reading skills of the Qur’an. They stated that many of the new students at UNY, from year to year, are still stuttering and being inarticulate when reading the Qur’an. Therefore, this study aimed to determine the ability to read the Qur’an for the new FIS UNY students in the even semester of the 2020/2021 academic year. This study took the data from the implementation of the 2020/2021 Islamic Religious Education course. The research was carried out using a survey , which is populative in nature, meaning that it counts all students who took part in the tutorial for the Islamic Religious Education course in the 2020/2021 academic year. The results showed that most of the new FIS UNY students for the 2020/2021 academic year were still in volume 2, in which they read between letters disjointly and incorrectly pronouncing vowels (fathah, kasrah, dhummah, and tanwin) or mixed up. Meanwhile, at the end of the semester, there was an increase in the number of students who entered volumes three and four, even five, reaching 74%.
China’s Aid policy approach to Poverty Alleviation in the recipient country: A Case study of the Republic of Guinea
Authors: Diakite Ansoumane Douty 
Published: April 2023

This paper examines the extent to which China’s aid policies integrate poverty alleviation as a goal of their aid in general, particularly in Guinea. More specifically, the paper analyzed how aid donors focus on poverty alleviation and which policies and mechanisms are in place to address poverty in the countries receiving aid. Regarding the methodology, the author collected data from secondary sources, including government declarations of donors, policy documents at both the donor and recipient levels, as well as from scholarly publications. The following findings resulted from study: China’s aid policies have progressively incorporated poverty alleviationobjectives and identified sectors for intervention against poverty. However, the limitations of China approach to poverty is that China adopts a top-down approach to poverty reduction and lacks of an impact evaluation mechanism based on poverty alleviation.
Pengaruh Akuntansi Hijau dan Kinerja Lingkungan terhadap Kinerja Keuangan dengan Tanggung Jawab Sosial sebagai Pemediasi
Authors: Handoko Jesica , Santoso Victor 
Published: April 2023

ABSTRACTThis study aims to examine the influence of green accounting to environmental performance with corporate social responsibility (CSR) mediation. The object of research is manufacturing companies listed on the Indonesia Stock Exchange from 2019-2021, namely 132 samples of manufacturing companies selected through a purposive sampling technique. Sources of data are obtained from the company's annual and sustainability reports as well as PROPER ratings. The results of the path analysis test show that green accounting has a negative effect on the company's financial performance, while environmental performance has a positive effect on the company's financial performance. The results also show that green accounting has a positive effect on financial performance through CSR as mediation, while the effect of environmental performance cannot be mediated by CSR. The findings conclude that the more environmental costs incurred to support green accounting through CSR activities, the firm's financial performance will improve. The higher the company's environmental performance (PROPER rating) will encourage the company's CSR activities, but it has not yet affected the company's financial performance.Keywords: Green Accounting, Environmental Performance, Financial Performances, Corporate Social ResponsibilityABSTRAKPenelitian ini bertujuan menguji pengaruh akuntansi hijau terhadap kinerja lingkungan dengan tanggung jawab sosial sebagai pemediasi. Objek penelitian adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2019-2021 yaitu 132 sampel tahun perusahaan yang dipilih melalui teknik purposive sampling. Sumber data diperoleh dari laporan tahunan dan keberlanjutan perusahaan serta peringkat PROPER. Hasil uji analisis jalur menunjukkan bahwa akuntansi hijau berpengaruh negatif terhadap kinerja keuangan perusahaan, sedangkan kinerja lingkungan berpengaruh positif terhadap kinerja keuangan perusahaan. Hasil penelitian juga menunjukkan bahwa akuntansi hijau memiliki pengaruh positif terhadap kinerja keuangan melalui tanggung jawab sosial sebagai mediasi, sedangkan pengaruh kinerja lingkungan tidak dapat dimediasi oleh tanggung jawab sosial . Temuan menyimpulkan bahwa semakin banyak biaya lingkungan yang dikeluarkan untuk mendukung akuntansi hijau melalui aktivitas tanggung jawab sosial perusahaan, akan meningkatkan kinerja keuangan perusahaan. Makin tinggi kinerja lingkungan (peringkat PROPER) perusahaan akan mendorong dilakukannya aktivitas tanggung jawab sosial perusahaan, akan tetapi belum mempengaruhi kinerja keuangan perusahaan.Kata Kunci: Akuntansi Hijau, Kinerja Lingkungan, Kinerja Keuangan, Tanggung Jawab Sosial
Mobile Apps and Quality of Life in Patients With Breast Cancer and Survivors: Systematic Literature Review
Authors: Saevarsdottir Saeunn Rut , Gudmundsdottir Sigridur Lara 
Published: April 2023

Background
Side effects of breast cancer treatment may persist long into survivorship, reducing quality of life (QOL) in patients with breast cancer and survivors. There is growing evidence for the use of digital health technologies, such as mobile apps, to support self-management, decrease symptom burden, and improve QOL in patients with cancer. However, an updated overview of the effects of mobile apps on QOL and well-being in patients with breast cancer and survivors is needed.

Objective
The aim of this review was to provide an overview of breast cancer–specific, mobile app–driven lifestyle or behavioral interventions in patient care through to survivorship and their impact on QOL and mental well-being.

Methods
A systematic search of PubMed, Scopus, and Web of Science was conducted to identify relevant studies. The inclusion criteria were limited to original studies involving a trial of a mobile app–driven lifestyle or behavioral intervention for patients with breast cancer or survivors and using QOL or well-being measures. The results of the studies that met the inclusion criterion were then synthesized in text and table format. The quality of the evidence was assessed with the Cochrane risk-of-bias tool.

Results
A total of 17 studies with the number of participants ranging from 23 to 356 met the inclusion criterion. Of the 17 reviewed studies, 7 (41%) delivered an app-only intervention, and 10 (59%) combined an app with additional supporting materials, such as SMS text messaging, telecoaching, wearables, or printed materials. Among the 17 reviewed studies, 6 (35%) focused on aiding patients with breast cancer during the active treatment phase (excluding ongoing hormone therapy), whereas the remaining 11 (65%) focused on survivorship. The majority of the studies (14/17, 82%) observed some positive effects on QOL or well-being measures.

Conclusions
The results of the review indicate that mobile apps are a promising avenue for improving QOL and well-being in breast cancer care. Positive effects were observed in patients undergoing active treatment in all reviewed studies, but effects were less clear after chemotherapy and in long-term survivors. Although lifestyle and behavioral digital interventions are still being developed, and further research should still be pursued, the available data suggest that current mobile health apps aid patients with breast cancer and survivors.
Profil Skala Nyeri dan Kadar Interleukin-6 pada Pasien Ulkus Kornea Bakteri di RS Mata “Dr. YAP” dan RSUP Dr. Sardjito Berdasarkan Profil Terapi: Prospective Case Series
Authors: Shabrina Bani Adlina , Puspitasari Ika , Pawiroranu Suhardjo 
Published: April 2023

Ulkus kornea merupakan kondisi kegawatdaruratan mata yang ditandai dengan inflamasi pada kornea dan adanya infiltrat pada kornea akibat defek epitel. Penyebab utama dari ulkus kornea adalah infeksi bakteri. Case series ini bertujuan untuk mengetahui profil kadar interleukin-6 dan skala nyeri pada pasien ulkus kornea bakteri di indonesia berdasarkan profil terapi. Penelitian ini merupakan penelitian prospektif observasional, dengan parameter berupa penurunan kadar interleukin-6 (IL-6) dan skala nyeri berdasarkan visual analogue scale (VAS). Terdapat 2 (dua) kasus ulkus kornea bakteri di Rumah Sakit Mata “Dr. YAP” and Rumah Sakit Umum Pusat Dr. Sardjito yang dibahas dalam case series ini. Kasus 1 (satu) berasal dari Rumah Sakit Mata “Dr. YAP” dan merupakan laki-laki berusia 14 tahun yang didiagnosis ulkus kornea dengan tingkat keparahan sedang, durasi penyakit selama 2 (dua) bulan, dan penyebab penyakit tidak diketahui. Kasus 2 (dua) berasal dari Rumah Sakit Umum Pusat Dr. Sardjito dan merupakan pria berusia 33 tahun yang didiagnosis ulkus kornea dengan tingkat keparahan berat, durasi penyakit selama 3 hari, dan penyebab penyakit tidak diketahui. Hasil penelitian ini menunjukkan bahwa profil terapi yang berbeda-beda tetap memberikan penurunan kadar IL-6 dan skala nyeri (VAS) pada semua kasus ulkus kornea bakteri dengan tingkat keparahan, durasi, dan penyebab penyakit masing-masing.
Hubungan Tingkat Pengetahuan dan Kepatuhan Terhadap Luaran Klinik Pasien Diabetes Mellitus melalui Metode Brief Counseling di Puskesmas di Kabupaten Pemalang
Authors: Yasin Nanang Munif , Syafitri Irrene Wulan , Sari Ika Puspita 
Published: April 2023

Pandemi COVID-19 menyebabkan terjadinya penurunan interaksi kegiatan rutin PROLANIS pasien Diabetes Mellitus (DM) tipe 2 di fasilitas kesehatan tingkat pertama. Tujuan dari penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien DM tipe 2 setelah pemberian brief counseling oleh apoteker. Jenis penelitian ini adalah quasi-experimental dengan metode pretest and posttest design with control group. Penelitian ini dilakukan secara prospektif untuk menganalisis hubungan tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien Diabetes Mellitus setelah pemberian brief counseling. Tingkat pengetahuan diukur menggunakan kuesioner Diabetic Knowledge Questionnaire-24 (DKQ-24), tingkat kepatuhan diukur menggunakan kuesioner Morisky Green Levine Scale (MGLS), dan luaran klinik pasien DM tipe 2 berupa glukosa darah puasa (GDP) di Puskesmas di Kabupaten Pemalang pada periode Oktober hingga November 2021. Analisis data karakteristik subjek penelitian menggunakan metode deskriptif dan disajikan dalam bentuk presentasi dan frekuensi. Analisis untuk mengetahui hubungan antara tingkat pengetahuan dan kepatuhan terhadap luaran klinik menggunakan uji chi-square dengan tingkat kepercayaan 95% (α = 0,05). Penelitian ini terdiri dari 32 pasien pada masing-masing kelompok kontrol dan intervensi. Hasil analisis deskriptif penelitian ini menunjukkan tidak terdapat perbedaan data karakteristik subjek penelitian pada kelompok kontrol dan intervensi (p>0,05). Hasil analisis bivariat terkait korelasi menunjukkan adanya hubungan antara tingkat pengetahuan terhadap luaran klinik (p=0,000), dan tingkat kepatuhan terhadap luaran klinik pasien DM tipe 2 (p=0,000). Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa ada hubungan yang bermakna antara tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien DM tipe 2 setelah pemberian brief counseling oleh apoteker.
The Stability Study of Electrochemical Aptasensor to Detect SARS-CoV-2 Spike Protein and Its Application for Clinical Samples of Nasopharyngeal Swab
Authors: Sari Arum Kurnia , Fadhilah Ghina Nur , Irkham Irkham , Yusuf Muhammad , Gaffar Shabarni , Hartati Yeni Wahyuni 
Published: April 2023

The stability characteristics associated with the shelf life of a biosensor are rarely investigated, however, they are important factors for real applications. Stability is the variation in the detection signal over a long period of storage. This study aims to determine the effect of storage time on the stability of SARS-CoV-2 receptor binding domain (RBD) spike protein aptamers related to shelf life and the performance of an electrochemical aptasensor on clinical samples. The research method includes a stability study conducted using the accelerated stability method based on the Arrhenius equation at three variations of temperature and storage time. The electrochemical aptasensor's performance was evaluated on clinical samples of 32 nasopharyngeal swabs at biosafety level 3 and its potential on clinical saliva samples. The results indicated that the developed electrochemical aptasensor was stable for ± 15 days with a shelf life of 18, 17 and 16 days, respectively, at 25, 40 and 50 °C. This electrochemical aptasensor has the potential to be a Point of Care (POC) device for the clinical detection of SARS-CoV-2 because it can be tested on clinical samples of nasopharyngeal swabs and the results show its potential application to detect in clinical saliva samples.
Indonesian Purple Rice Ferulic Acid as a Candidate for Anti-aging through the Inhibition of Collagenase and Tyrosinase Activities
Authors: Wijayanti Ernanin Dyah , Safitri Anna , Siswanto Dian , Fatchiyah Fatchiyah 
Published: April 2023

Skin aging is associated with decreased skin firmness and excessive pigmentation, which is caused by the activity of aging enzymes. This process can be prevented with powerful antioxidants from nature, such as ferulic acid which is abundant in rice. This study examines the nutritional content and phytochemicals of Indonesian purple rice and evaluates the bioactivity of ferulic acid as an anti-aging agent. Indonesian purple rice has less fat than black and white rice, more amino acids involved in aging regulation, and a similar phytochemical profile to black and white rice. Indonesian purple rice has a lower concentration of ferulic acid (4.114 ± 0.013 mg/L) than black rice but shows strong reducing power (IC50 9.35 ± 1.95 µg/mL), high anti-tyrosinase (IC50 59.57 ± 3.60 µg/mL), and moderate anti-collagenase activities (IC50 74.18 ± 3.11 µg/mL). This study supports the use of Indonesian purple rice as a promising active ingredient in natural anti-aging cosmetics.
Calcium Phosphate Cement Composed of Hydroxyapatite Modified Silica and Polyeugenol as a Bone Filler Material
Authors: Windarti Tri , Prasetya Nor Basid Adiwibawa , Ngadiwiyana Ngadiwiyana , Nulandaya Limpat 
Published: April 2023

A composite of hydroxyapatite modified silica (HASiO2) and 10% (w/w) polyeugenol (PE) was synthesized to produce a calcium phosphate cement with antibacterial activity. The compatibility of the composite (HASiO2_PE) with bone filler requirements was determined due to its crystal, surface, antibacterial, and cytocompatibility properties. The results showed that compositing HASiO2 and PE did not affect HA's chemical dan crystal properties. The presence of PE changed HASiO2 morphology to be coarser and denser than before composited. PE tends to agglomerate but does not affect the hydrophilicity of HASiO2. The presence of PE increased the surface area and total pore volume but lowered the average pore size. Different from pure PE, the composite of HASiO2_PE that contains of 10% PE has higher antibacterial activity toward Escherichia coli than Staphylococcus aureus. The composite is biocompatible because the cytotoxicity test toward pre-osteoblast cells resulted in an IC50 of 2092 μg/mL. Thus, due to its chemical, surface, antibacterial, and cytocompatibility properties, the HASiO2_PE composite can be recommended as a bone filler material.