bluuebunny/crossref_metadata_2025_split huggingface dataset:
A participatory study of college students’ mental health during the first year of the COVID-19 pandemic
Authors: Park Chulwoo , McClure Fuller Melissa , Echevarria Thea Marie , Nguyen Kim , Perez Daisy , Masood Hufsa , Alsharif Tasneem , Worthen Miranda 
Published: March 2023

IntroductionThe COVID-19 pandemic has negatively impacted college students’ mental health and wellbeing. Even before the pandemic, young adults reported high mental health morbidity. During the pandemic, young adult college students faced unprecedented challenges, including campus closure and a pivot to fully online education.MethodsThis study employed a novel participatory approach to a Course-based Undergraduate Research Experience (CURE) in an introductory epidemiology course to examine factors students considered important regarding their experience during the pandemic. Two groups of undergraduate students enrolled in this course (one in Fall 2020 and another in Spring 2021) and participated in the CURE. A sub-group of these students continued after the class and are authors of this article. Through repeated cross-sectional surveys of college students’ peer groups in northern California in October 2020 and March 2021, this student/faculty collaborative research team evaluated depression, anxiety, suicidal ideation and several other topics related to mental health among the students’ young adult community.ResultsThere was a high prevalence of anxiety (38.07% in October 2020 and 40.65% in March 2021), depression (29.85% in October 2020 and 27.57% in March 2021), and suicidal ideation (15.94% in October 2020 and 16.04% in March 2021). In addition, we identified the significant burden of loneliness for college students, with 58.06% of students reporting feeling lonely at least several days in the past two weeks. Strategies that students used to cope with the pandemic included watching shows, listening to music, or playing video games (69.01%), sleeping (56.70%), taking breaks (51.65%), and connecting with friends (52.31%) or family (51.21%). Many reported distressing household experiences: more than a third reporting loss of a job or income (34.27%) in the first year of the pandemic. We explain the participatory research approach and share empirical results of these studies.DiscussionWe found this participatory CURE approach led to novel, experience-based research questions; increased student motivation; real-world benefits such as combatting imposter syndrome and supporting graduate school intentions; integration of teaching, research, and service; and development of stronger student-faculty relationships. We close with recommendations to support student wellbeing and promote student engagement in research.
Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank
Authors: Yu Xing-Hao , Cao Han-Wen , Bo Lin , Lei Shu-Feng , Deng Fei-Yan 
Published: March 2023

PurposeTo reveal relationship between air pollution exposure and osteoporosis (OP) risk.MethodsBased on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution scores (APS) were constructed to assess the combined effects of multiple air pollutants on OP risk. Finally, we constructed a genetic risk score (GRS) based on a large genome-wide association study of femoral neck bone mineral density and assessed whether single or combined exposure to air pollutants modifies the effect of genetic risk on OP and fracture risk.ResultsPM2.5, NO2, NOx, and APS were significantly associated with an increased risk of OP/fracture. OP and fracture risk raised with increasing concentrations of air pollutants: compared to the lowest APS quintile group, subjects in the highest quintile group had a hazard ratio (HR) (95% CI) estimated at 1.140 (1.072–1.213) for OP and 1.080 (1.026–1.136) for fracture. Moreover, participants with low GRS and the highest air pollutant concentration had the highest risk of OP, the HRs (95% CI) of OP were 1.706 (1.483–1.964), 1.658 (1.434–1.916), 1.696 (1.478–1.947), 1.740 (1.506–2.001) and 1.659 (1.442–1.908), respectively, for PM2.5, PM10, PM2.5−10, NO2, and NOx. Similar results were also observed for fractures. Finally, we assessed the joint effect of APS and GRS on the risk of OP. Participants with higher APS and lower GRS had a higher risk of developing OP. Similar results were observed in the joint effect of GRS and APS on fracture.ConclusionsWe found that exposure to air pollution, individually or jointly, could improve the risk of developing OP and fractures, and increased the risk by interacting with genetic factors.
Comparison of structural occipital and iliac bone grafts for instrumented atlantoaxial fusions in pediatric patients: Radiologic research and clinical outcomes
Authors: Liang Zhi-Hui , Zhang Yue-Hui , Liu Hai-Tao , Zhang Qiu-Qi , Song Jia , Shao Jiang 
Published: March 2023

BackgroundStructural autografts harvested from the iliac bone have been used in atlantoaxial fusion; they have been the gold standard for years. However, emerging occipital bone grafts have the advantage of avoiding donor-site morbidity and complications. Thus, we compared the clinical outcomes of structural autografts from the occipital bone or iliac crest and discussed the clinical significance of occipital bone grafts in pediatric patients.MethodsPediatric patients who underwent posterior fusion using occipital bone grafts (OBG) or iliac bone grafts (IBG) between 2017 and 2021 were included in this study. Data on clinical outcomes, including operation time, estimated blood loss, length of hospitalization, complications, fusion rate, and fusion time, were collected and analyzed. Additionally, 300 pediatric patients who underwent cranial computed tomography scans were included in the bone thickness evaluation procedure. The central and edge thicknesses of the harvested areas were recorded and analyzed.ResultsThirty-nine patients were included in this study. There were no significant differences in patient characteristics between the OBG and IBG groups. Patients in both groups achieved a 100% fusion rate; however, the fusion time in the OBG group was significantly longer than that in the IBG group. Estimated blood loss, operation time, and length of hospitalization were significantly lower in the OBG group than those in the IBG group. The surgery-related complication rate was lower, but not significantly, in the OBG group than that in the IBG group. For occipital bone thickness evaluation, a significant difference in the central part of the harvesting area was found between the young and old groups, with no significant sex differences.ConclusionThe use of OBG for atlantoaxial fusion is acceptable for pediatric patients with atlantoaxial dislocation, avoiding donor-site morbidity and complications.
Case report: Laparoscopic-assisted distal gastrectomy for gastric cancer in a patient with situs inversus totalis
Authors: Zhu Kaifeng , Hu Qiang , Sun Yuanshui 
Published: March 2023

BackgroundSitus inversus totalis (SIT) is a rare congenital disease with a series of clinical features characterized by a mirror image distribution of the viscera to the normal anatomy.Case presentationThis study aims to report a 63-year-old male SIT patient with gastric cancer with a preoperative diagnosis of stage IIB gastric cancer (cT3N0M0), who underwent a preoperative multi-disciplinary treatment (MDT) discussion and an abdominal enhancement CT for visceral evaluation to ensure a successful operation. A laparoscopic-assisted distal gastrectomy including D2 lymph node dissection and Billroth I reconstruction was successfully performed. Laparoscopic radical gastric gastrectomy and D2 lymph node dissection were performed through the opposite surgical station to the conventional one, followed by digestive tract reconstruction under small incision-assisted direct vision. There was less blood loss throughout the operation, no postoperative complications, and the patient was discharged successfully 10 days after surgery. Histopathological examination showed ulcerated high-medium differentiated adenocarcinoma stage IB (PT2N0M0). There were no complications or tumor recurrence in the patient with examination 6 months after the operation.ConclusionSurgery in a patient with gastric cancer and SIT can be safely performed by the application of 3D laparoscopy and small incisions to assist the digestive tract reconstruction under direct vision.
Automatic gross tumor segmentation of canine head and neck cancer using deep learning and cross-species transfer learning
Authors: Groendahl Aurora Rosvoll , Huynh Bao Ngoc , Tomic Oliver , Søvik Åste , Dale Einar , Malinen Eirik , Skogmo Hege Kippenes , Futsaether Cecilia Marie 
Published: March 2023

BackgroundRadiotherapy (RT) is increasingly being used on dogs with spontaneous head and neck cancer (HNC), which account for a large percentage of veterinary patients treated with RT. Accurate definition of the gross tumor volume (GTV) is a vital part of RT planning, ensuring adequate dose coverage of the tumor while limiting the radiation dose to surrounding tissues. Currently the GTV is contoured manually in medical images, which is a time-consuming and challenging task.PurposeThe purpose of this study was to evaluate the applicability of deep learning-based automatic segmentation of the GTV in canine patients with HNC.Materials and methodsContrast-enhanced computed tomography (CT) images and corresponding manual GTV contours of 36 canine HNC patients and 197 human HNC patients were included. A 3D U-Net convolutional neural network (CNN) was trained to automatically segment the GTV in canine patients using two main approaches: (i) training models from scratch based solely on canine CT images, and (ii) using cross-species transfer learning where models were pretrained on CT images of human patients and then fine-tuned on CT images of canine patients. For the canine patients, automatic segmentations were assessed using the Dice similarity coefficient (Dice), the positive predictive value, the true positive rate, and surface distance metrics, calculated from a four-fold cross-validation strategy where each fold was used as a validation set and test set once in independent model runs.ResultsCNN models trained from scratch on canine data or by using transfer learning obtained mean test set Dice scores of 0.55 and 0.52, respectively, indicating acceptable auto-segmentations, similar to the mean Dice performances reported for CT-based automatic segmentation in human HNC studies. Automatic segmentation of nasal cavity tumors appeared particularly promising, resulting in mean test set Dice scores of 0.69 for both approaches.ConclusionIn conclusion, deep learning-based automatic segmentation of the GTV using CNN models based on canine data only or a cross-species transfer learning approach shows promise for future application in RT of canine HNC patients.
Five New Cantharidin Derivatives from the Insect Mylabris cichorii L. and Their Potential against Kidney Fibrosis In Vitro
Authors: Li Ke-Ming , Li Ji-Jun , Wan Li , Cheng Yong-Xian 
Published: March 2023

Five new monoterpenoids including three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (1, 2, and 5) and two 1,2-dimethyl cantharimide-type derivatives (3 and 4), together with three known compounds (6–8) were isolated from the insect Mylabris cichorii Linnaeus. The structures of these new compounds, including their absolute configurations, were characterized by detailed analysis of NMR, chemical derivatization, and quantum chemical ECD calculations. All of the compounds were tested for their biological activity against kidney fibrosis. The results revealed that compounds 2, 4, and 7 could inhibit kidney fibrosis in vitro at 40 μM by inhibiting the expression of fibronectin and collagen I in TGF-β1-induced NRK-52e cells.
Analisis Usahatani Budidaya Tanaman Selada Kepala Secara Konvensional
Authors: Utami Esty Puri , Anwar Nyi Mas Roihani 
Published: March 2023

Selada kepala merupakan jenis tanaman sayuran daun semusim yang kaya akan kandungan gizi yang baik bagi tubuh manusia serta memiliki prospek yang menjanjikan untuk dikembangkan. Namun tentu selama proses budidayanya tidak sedikit mengalami kendala dan hambatan, baik dari faktor internal maupun eksternal. Penelitian ini dilakukan di Gapoktan Lembang Agri yang berlokasi di Kp. Pengkolan, Desa Cikidang, Kecamatan Lembang, Kabupaten Bandung Barat. Penelitian ini bertujuan untuk mengetahui teknik budidaya, pemasaran dan kendala yang dihadapi, serta menganalisis kelayakan usaha dengan cara menghitung penerimaan dan pendapatan. Metode dalam penelitian ini menggunakan metode kualtitatif dan metode kuantitatif dengan cara analisis pendapatan usahatani, kemudian dilanjutkan dengan analisis R/C ratio untuk mengetahi kelayakan usaha. Hasil penelitian menunjukkan teknik budidaya selada kepala secara konvensional meliputi kegiatan persiapan awal diantaranya pengolahan tanah, pemupukan dasar, pembuatan bedengan, pemasangan mulsa dan pembuatan lubang tanam. Kemudian persemaian, pindah tanam, pemeliharaan, panen dan penanganan pasca panen. Pemasaran dilakukan secara saluran langsung (zero levels channel or direct marketing channel) dari produsen ke konsumen, tanpa menggunakan perantara pengepul. Total biaya yang dikeluarkan dan pendapatan yang diperoleh dalam usahatani selada kepala ini berturut- turut adalah sebesar Rp 26.130.000 dan Rp 18.870.000, dengan nilai R/C rasio 1,72. Kendala yang dihadapi meliputi cuaca dan perubahan iklim serta pemasarannya.
Faktor Sosial Ekonomi yang Mempengaruhi Pendapatan Usahatani Padi Sawah di Masa Pandemi Covid-19
Authors: Zulkarnain Zulkarnain , Isnaini Soni , Rakhmiati Rakhmiati , Handayani Etik Puji , Maryati Maryati , Yatmin Yatmin , Supriyadi Supriyadi , Hariyanto Adi , Ferdiansyah Arif 
Published: March 2023

Tujuan penelitian adalah menganalisis pendapatan usahatani padi sawah dan menganalisis faktor-faktor sosial ekonomi yang mempengaruhi pendapatan usahatani padi sawah di masa pandemi covid-19. Analisis yang digunakan analisis pendapatan dan analisis regresi linier berganda. Teknik pengambilan sampel yaitu simple random sampling sebanyak 51 petani. Hasil penelitian yaitu pendapatan usahatani padi sawah sebesar Rp. 10,368,541.00 /ha/musim tanam dengan nilai R/C ratio sebesar 2,1 (menguntungkan). Faktor sosial ekonomi yang berpengaruh terhadap pendapatan usahatani padi sawah adalah luas lahan, harga pupuk organik, dan harga pupuk ponska, sedangkan faktor yang tidak berpengaruh nyata terhadap pendapatan usahatani padi sawah adalah tingkat pendidikan, harga pupuk kandang, harga pupuk urea, harga pupuk ZA, harga pupuk KCL, harga pestisida, jumlah anggota keluarga dan usia.
PENGARUH STORE ATMOSPHERE TERHADAP KEPUASAN KONSUMEN PADA AYAM PENYET CINDELARAS BAGAN BATU KABUPATEN ROKAN HILIR
Authors: Ema Fitri Lubis  , Herman  , Tirza Tantri Indira  
Published: March 2023

Suasana (Store Atmospere) adalah salah satu hal yang dapat dilakukan oleh pemilik restoran dan kafe untuk bersaing dengan para pesaingnya, karena Store Atmospere bisa jadi salah satu hal yang dapat meningkatkan kepuasan konsumen pada saat melakukan kunjungan ke store tersebut. Tujuan penelitian ini adalah untuk menganalisis dan menjelaskan pengaruh sotre atmosphere terhadap kepuasan konsumen pada ayam penyet Cinderelas Bagan Batu Kabupaten Rokan Hilir. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan deskriptif. Responden dalam penelitian ini sebanyak 100 orang responden dengan cara pengambilan sampel menggunakan metoda non probability dengan Teknik incidental sampling. Metoda pengumpulan data terdiri dari kuesioner, observasi dan dokumentasi. Analisis data dalam penelitian ini menggunakan analisis regresi linier sederhana. Hasil penelitian menunjukan bahwa variabel X yaitu store atmosphere terkategorikan baik, sedangkan variavel Y yaitu kepuasan konsumen juga terkategorikan baik. Untuk hasil regresi linier sederhana menunjukan bahwa store atmosphere mempunyai hubungan signifikan terhadap kepuasan konsumen.
EFEKTIVITAS PELAKSANAAN PROGRAM BANTUAN PANGAN NON TUNAI SEBAGAI UPAYA PENANGANAN FAKIR MISKIN DI DESA PANYIPATAN KECAMATAN PANYIPATAN KABUPATEN TANAH LAUT
Authors: Widiati  
Published: March 2023

Abstrak
Indikator pemahaman program pada masyarakat Panyipatan program BPNT dapat dikatakan baik. Akan tetapi disisi lain pada indikator ketepatan sasaran serta indikator ketepatan waktu masih ada hal yang perlu diperbaiki pada program ini. Meskipun begitu indikator tercapainya tujuan pada program BPNT yang dilakukan saat ini sudah terealisasi pencapaiannya, tujuan dari program ini telah terlaksana dengan baik dan terakhir pada indikator perubahan nyata dampak yang dirasakan oleh masyarakat (KPM) yang sudah terbantu khususnya dalam hal pangan yang dapat memenuhi sebagian kebutuhan pangan sehari-hari sehingga dapat memberikan nutrisi yang seimbang kepada KPM serta mengurangi beban pengeluaran dan dapat membantu perekonomian KPM. Bedasarkan hasil penelitian maka peneliti merekomendasikan beberapa hal yang perlu diterapkan seperti pada indikator pemahaman program bisa dilakukan sosialisasi kepada KPM. indikator tepat sasaran, kepada petugas untuk bisa survey langsung ke lapangan dalam meningkatkan ketepatan sasaran. Indikator tepat waktu meningkatkan koordinasi antara pihak terkait dengan pemerintah pusat agar penyaluran BPNT bisa dilakukan rutin setiap bulan dan sesuai dengan tanggal yang telah ditentukan sebelumnya. Selnjutnya indikator tercapainya tujuan, perlu ditingkatkan lagi evaluasi kepada KPM mengenai bantuan tersebut karena masih ada KPM yang saldonya nol, dan untuk indikator perubahan nyata diharapkan program ini terus berlanjut dan untuk penerima nya bisa diperluas sehingga tujuan dari program BPNT untuk mengurangi biaya pengeluaran dalam meningkat perekonomian masyarakat dapat tercapai.

Kata Kunci : Efektivitas, pelaksanaan BPNT, Penanganan Fakir Miskin
Sarcoidosis and Airway Disease After Immune Checkpoint Inhibitor Therapy: Case Study and Review of the Literature
Authors: Soto Felipe , Torre-Sada Luis F. , Mott Frank E. , Kim Sang T. , Nurieva Roza , Nagarajan Priyadharsini , Guo Ming , Shannon Vickie R. , Faiz Saadia A. , Casal Roberto F. , Altan Mehmet , Lin Julie , Sheshadri Ajay 
Published: March 2023

ABSTRACT
Pulmonary toxicity from immune checkpoint inhibitor therapy is typically a severe and potentially fatal complication, but these observations are driven by the most common toxicity, pneumonitis. Rarer pulmonary immune related adverse events, like airway disease and sarcoidosis, may have a more benign course. In this case report, we present a patient in whom therapy with the PD-1 inhibitor pembrolizumab resulted in severe eosinophilic asthma and sarcoidosis. This is the first case showing that anti–IL-5 inhibition may be safe in patients who develop eosinophilic asthma after ICI therapy. We further show that sarcoidosis does not necessarily require treatment cessation. This case highlights relevant nuances when clinicians face pulmonary toxicities other than pneumonitis.
Pengaruh Gaya Kepemimpinan Transformasional dan Kepercayaan Terhadap Kepuasan Kerja yang Dimediasi oleh Motivasi Kerja Pegawai Negeri Sipil Kabupaten Lamandau
Authors: Hartati Islia , Sambung Roby , Siolemba Patiro Shine Pintor 
Published: March 2023

Pegawai Negeri Sipil di Kabupaten Lamandau merasakan pengaruh gaya kepemimpinan transformasional dan kepercayaan terhadap kepuasan kerja yang juga dimediasi oleh motivasi. Tujuan penelitian ini adalah bertujuan untuk mengungkap pengaruh gaya kepemimpinan transformasional dan kepercayaan terhadap kepuasan kerja yang dimediasi oleh motivasi kerja para Pegawai Negeri Sipil yang ada di Kabupaten Lamandau. Penelitian ini dilakukan pada seluruh Pegawai Negeri Sipil Kabupaten Lamandau dengan populasi berjumlah 2.748 Sampel yang digunakan adalah sebanyak 350 responden. Variabel pada penelitian ini adalah Kepemimpinan Transformasional, Kepercayaan dan Kepuasan Kerja dengan variabel mediasi adalah Motivasi. Pengukuran variabel dilakukan dengan menggunakan skala Likert. Analisis data dilakukan dengan menggunakan metode Strucutral Equation Model (SEM). Perangkat lunak yang digunakan untuk analisis structural adalah AMOS 20 dan dari Arbuckle dan untuk analisis deskriptif menggunakan SPSS 22. Berdasarkan hasil pengujian hipotesis pada penelitian ini menunjukkan bahwa kemampuan kemampuan kepemimpinan transformasional dalam menjelaskan varians kepercayaan adalah 60,80%, Kepercayaan terhadap motivasi adalah 53,2%, dan kepercayaan serta motivasi dalam menjelaskan varians kepuasan kerja adalah sebesar 65,20%. Berdasarkan hasil penelitian ini rata-rata nilai communality adalah 0,631 dan nilai rata-rata R-square adalah 0,597, maka nilai Goodness of Fit (GoF) indeks model penelitian ini adalah = 0,613. Sebagaimana yang dikemukakan oleh Tenenhaus et al (2005) bahwa nilai GoF di atas 0,5 sudah dapat dikategorikan baik. Dalam penelitian ini ditemukan bahwa kepemimpinan transformasional mempengaruhi kinerja tim melalui keselarasan nilai dan kepercayaan yang terbentuk antara atasan dan bawahan. Sebagaimana hasil penelitian ini, kepercayaan yang dibentuk oleh kepemimpinan transformasional mampu menjelaskan dengan baik varians dari motivasi sebesar 53,2% dan kepuasan kerja sebesar 65,2%.
REDUCING THE PROBABILITY COEFFICIENT OF BIT ERRORS IN A DIGITAL COMMUNICATION SYSTEM
Authors: Свиридова И.В. , Хорошайлова М.В. , Маркин В.А. 
Published: March 2023

моделируется и анализируется снижение частоты ошибок с помощью кода Хэмминга в среде MATLAB / Simulink. В системах связи при передаче и приеме данных возникают ошибки из-за нежелательных шумов и помех в канале связи, поэтому для эффективной передачи данных необходимо получать данные без ошибок. Канальный кодер добавляет биты к передаваемым битам сообщения. Декодер канала интерпретирует полученное сообщение, используя избыточные символы для обнаружения и возможного исправления ошибок, которые могли возникнуть во время передачи. Техника кодирования с контролем ошибок заключается в обнаружении и возможном исправлении ошибочно переданной информации путем внесения избыточности в поток битов, передаваемых по каналу, и также обеспечивает безопасную и надежную передачу данных по несовершенному зашумленному каналу. В зависимости от характера шума применяется определенный тип кодирования с контролем ошибок. Проведенные анализ и наблюдение за коэффициентом ошибок системы с использованием техники блочного кодирования, в частности кода Хэмминга, в результате показали, что коэффициент ошибок снижается до значительного уровня и результаты проверены с помощью теоретических и практических методов
the error rate reduction using Hamming code in the MATLAB / Simulink environment is simulated and analyzed in this paper. In communication systems, when transmitting and receiving data, errors occur due to unwanted noise and interference in the communication channel, therefore, for efficient data transmission, it is necessary to receive data without errors. The channel encoder adds bits to the transmitted message bits. The channel decoder interprets the received message using redundant symbols to detect and possibly correct errors that may have occurred during transmission. The error control coding technique is to detect and possibly correct erroneously transmitted information by introducing redundancy into the bit stream transmitted over the channel, and ensures safe and reliable data transmission over an imperfect noisy channel. Depending on the nature of the noise, a certain type of error control coding is applied. The analysis and observation of the error rate of the system carried out here using block coding techniques, in particular Hamming code, the results showed that the error rate is reduced to a significant level, and the results are verified using theoretical and practical methods