bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can habitat characteristics of a West African forest‐savanna mosaic landscape model bee community composition?
Authors: Soro Nicodénin Angèle , Koné N’Golo Abdoulaye , Silué Dolourou , Yéo Kolo , Dekoninck Wouter 
Published: July 2023

AbstractBees are vital to both ecosystems and humans worldwide; supplying a range of key support facilities for the successful breeding of the majority of flowering plants. The aim of this study was to assess the bee species composition in a Sudano‐Guinean savanna zone and determining the impact of a set of environmental parameters influencing this species composition in four habitat types. Sampling was carried using yellow pan traps protocol. A total of 846 bees belonging to 3 families, 25 genera and 52 species were collected. The largest number of bee individuals was found in the Apidae family. The most abundant species was Hypotrigona sp. The highest bee species and number of individuals was recorded in the shrubby savanna. Bee species diversity and abundance were found closely correlated with the plant diversity. Gaining a better understanding of the factors influencing bee community dynamics in the given landscape can provide valuable information for conservation efforts, habitat management and help identifying species which ones could be domesticated.
Travel‐associated cost savings to patients and the health system through provision of specialist head and neck surgery outreach clinics in rural New South Wales, Australia
Authors: Venchiarutti Rebecca L. , Pearce Alison , Mathers Lara , Dawson Tania , Ch'ng Sydney , Shannon Kerwin , Clark Jonathan R. , Palme Carsten E. 
Published: July 2023

AbstractIntroductionCentralisation of head and neck surgical services means that patients in regional and remote Australia need to travel long distances for treatment and follow‐up, imparting a significant financial burden on patients and the health system.ObjectiveTo estimate costs of travel to local outreach clinics and determine potential cost savings to patients and the health system by avoiding patient travel to major cities for head and neck surgical care.DesignRetrospective audit of three head and neck surgery outreach clinics in New South Wales, Australia over 4 years (2017–2020). Direct costs of travel from a patient's residence to their local outreach clinic were estimated. Costs of travel and accommodation to Sydney for an appointment were calculated for different travel modes. Estimated reimbursements for travel through government support schemes were calculated based on published rates.FindingsSome 657 patients attended the three clinics, accounting for 1981 appointments. Depending on mode of travel, the estimated median cost of return travel (including accommodation) to Sydney was $379 to $739 per patient per trip and the median government reimbursement ranged from $182 to $279 per trip. In comparison, the cost of return travel by car to local outreach clinics ranged from $28 to $163 per appointment. Outreach clinics were estimated to save patients a median of $285 per trip and avoided government reimbursements of $215 per trip.DiscussionDespite uptake in telehealth, outreach medical services remain an important asset for people living in regional areas to address inequities in access. However, the cost benefits are likely to be underestimated as our approach did not account for indirect costs associated with travel.ConclusionOutreach head and neck surgical services located in regional areas can reduce the financial burden on both patients and the healthcare system. Greater investment in outreach clinics could ensure sustainability of services to promote equitable access to specialised surgical services.
On the paradoxes of feminist praxis
Authors: Vijayakumar Gowri 
Published: July 2023

SummaryThis essay is part of a forum on Srila Roy's (2022) book, Changing the Subject. I suggest that Roy's book offers a way to sit with the paradoxes of feminist praxis by engaging with its everyday messiness and conflict. I read Roy's book through the lens of my research with sex worker activists in India, focusing on how Roy's attention to ambivalence helped me to rethink my analysis. Through ethnography, the book shows how her interlocutors strategize creatively under disempowering conditions, challenging narratives of loss and depoliticization in feminist movements. Finally, I reflect on questions the book raises about the practice of feminist research.
Neonatal outcomes following introduction of routine probiotic supplementation to very preterm infants
Authors: Healy David B. , Campbell‐Green Benjamin , Livingstone Vicki , Ryan C. Anthony , Ross R. Paul , Stanton Catherine , Dempsey Eugene M. 
Published: July 2023

AbstractAimTo evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants admitted to Cork University Maternity Hospital, Ireland, before and after introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics (Infloran®).MethodsA retrospective study of infants <32 weeks gestation and < 1500 g surviving beyond 72 h of life was performed. Two 6‐year epochs; pre‐probiotics (Epoch 1: 2008–2013) and with probiotics (Epoch 2: 2015–2020), were evaluated. The primary outcome was defined as death after 72 h or NEC Bell stage 2a or greater.ResultsSeven‐hundred‐and‐forty‐four infants were included (Epoch 1: 391, Epoch 2: 353). The primary outcome occurred in 67 infants (Epoch 1: 37, Epoch 2: 30, p = 0.646). After adjustment, the difference was significant (OR [95% CI]: 0.53 [0.29 to 0.97], p = 0.038). Differences between epochs did not depend on gestational age group (<28 weeks; ≥28 weeks).ConclusionThere was an associated reduction of the composite outcome of severe grade NEC and/or death, after adjustment for confounding variables, with introduction of routine administration of a B. bifidum and L. acidophilus probiotic at our institution.
Benefits of routine probiotic supplementation in preterm infants
Authors: Rath C. P. , Athalye‐Jape G. , Nathan E. , Doherty D. , Rao S. , Patole S. 
Published: July 2023

AbstractAimWe introduced routine probiotic supplementation (RPS) of preterm infants in June 2012. We previously reported that RPS reduced the incidence of necrotising enterocolitis (NEC) and mortality in such infants. In this study, we assessed if the benefits of RPS were sustained for infants in the current era.MethodWe compared the outcomes of preterm infants in recent epoch 3 (RPS, 1st June 2014 to 31st December 2019) versus epoch 2 (RPS, 1st June 2012 to 31st May 2014) and epoch 1 (no RPS, 1st December 2008 to 30th November 2010). Multiple logistic and Cox regression models were used to compare the outcomes.ResultsThere were 645 infants in epoch 1, 712 in epoch 2 and 1715 in epoch 3. Age at full feeds was significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants <28 weeks of gestation. NEC and late‐onset sepsis (LOS) were significantly lower in epoch 3 vs. 1 in infants <28 weeks. LOS and age at full feeds were significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants with gestation 28 to 32 weeks.ConclusionThe benefits associated with RPS were sustained during epoch 3.
The initiative paradox: A social comparison perspective on why and when relational crafting leads to loneliness
Authors: Chen Lu , Cao Wenyi , Qu Yuanmei , Kang Yu , Xiang Yilin , Tang Kaixuan 
Published: July 2023

AbstractDrawing upon social comparison theory, we investigated the influencing mechanism between relational job crafting and workplace loneliness and its boundary condition. A multiple‐source, multi‐wave field study was conducted with data collected from 267 employee–peer dyads in three Chinese firms. The results showed that there is an inverted U‐shaped relationship between promotion‐oriented relational crafting and loneliness via peer social undermining. Meanwhile, prevention‐oriented relational crafting is positively related to loneliness through peer social undermining. Moreover, impression management motive moderates the inverted U‐shaped relationship between promotion‐oriented relational crafting and peer social undermining. Implications of these findings are discussed.
How do working students fare? A person‐centric approach to understanding patterns of work–school conflict and facilitation
Authors: Headrick Lucille , Park Young Ah 
Published: July 2023

AbstractStudent workers are largely understudied in organizational research, yet they represent an important part of the workforce. Their numbers are expected to rise as tuition continues to increase, and many adult workers are returning to school. The current study utilizes a person‐centric approach to investigate latent patterns of work–school conflict (WSC) and work–school facilitation (WSF) as well as the antecedent (i.e., supervisor work–school support) and outcomes (i.e., job satisfaction, well‐being, and school outcomes) tied to these latent patterns across school weeks. In a pilot study (n = 178 student workers), we first confirmed whether classes of WSC and WSF could be identified using latent profile analysis. Then, using 347 weekly WSC and WSF experiences, multilevel latent profile analysis identified four distinct profiles of WSC and WSF at the week level. Also, this modeling demonstrated that individuals tend to fluctuate between at least two profiles across weeks. Supervisor work–school support was found to predict weekly profile membership. Furthermore, the week‐level profiles exhibited distinct relations with weekly outcomes (i.e., job satisfaction, well‐being, and school preparedness). The results provide important theoretical and practical insights into the joint experience of interrole conflict and facilitation among student workers.
Reduced incidence of tick paralysis cases in dogs and cats at two emergency clinics in South‐East Queensland since 2015: new generation prophylactics as possible explanatory variables
Authors: Ireland EM , Heller J , Leister EM , Padula AM 
Published: July 2023

IntroductionThis study aimed to determine the incidence of canine and feline tick paralysis cases presenting to two veterinary emergency hospitals before and after the introduction of new generation prophylactic acaricides.MethodsThis was a retrospective study, investigating the number of tick paralysis cases presenting to two emergency and critical care veterinary hospitals in South‐East Queensland, from 2008 to 2021. A total of 10,914 dogs and 3696 cats were included over the course of the study. To assess if the introduction of new generation prophylactics in 2015 has coincided with any variation in case numbers, data for each species were analysed graphically and numerically in the first instance, then interrupted time series analyses were performed for the dog and cat data independently.ResultsAccounting for seasonal and climatic variation, we estimated a 54.8% reduction in dog (95% CI 45.3%–62.7%) and 44% reduction in cat (95% CI 19.5%–46%) tick paralysis cases presenting to these two clinics. This reduction corresponded with the timing of new generation prophylactic agents being introduced, including isoxazolines and imidacloprid/flumethrin impregnated collars.ConclusionIn the population studied, a significant reduction in the incidence of tick paralysis cases treated by veterinarians has occurred from 2015 onwards and was found to be associated with the timing of the release of new generation acaricidal products.
Post‐prostatectomy anastomotic stenosis: systematic review and meta‐analysis of endoscopic treatment
Authors: Delchet Ophélie , Nourredine Mikaïl , González Serrano Adolfo , Morel‐Journel Nicolas , Carnicelli Damien , Ruffion Alain , Neuville Paul 
Published: July 2023

ObjectiveTo perform a systematic review and meta‐analysis of endoscopic procedures for treating vesico‐urethral anastomotic stenosis (VUAS) after prostatectomy, as initial VUAS management remains unclear.MethodsA search of the MEDLINE database, the Cochrane database, and clinicaltrials.gov was performed (last search February 2023) using the following query: ([‘bladder neck’ OR ‘vesicourethral anastomotic’ OR ‘anastomotic’] AND [‘stricture’ OR ‘stenosis’ OR ‘contracture’] AND ‘prostatectomy’). The primary outcome was the success rate of VUAS treatment, defined by the proportion (%) of patients without VUAS recurrence at the end of follow‐up.ResultsThe literature search identified 420 studies. After the screening, 78 reports were assessed for eligibility, and 40 studies were included in the review. The pooled characteristics of the 40 studies provided a total of 1452 patients, with a median (interquartile range [IQR]) follow‐up of 23.7 (13–32) months and age of 66 (64–68) years. The overall success rate (95% confidence interval [CI]) of all endoscopic procedures for VUAS treatment was 72.8% (64.4%–79.9%). Meta‐regression models showed a negative influence of radiotherapy on the overall success rate (P = 0.012). After trim‐and‐fill (addition of 10 studies), the corrected overall success rate (95% CI) was 62.9% (53.6%–71.4%).ConclusionThis first meta‐analysis of endoscopic treatment success rate after VUAS reported an overall success rate of 72.8%, lowered to 62.9% after correcting for significant publication bias. This study also highlighted the need for a more thorough reporting of post‐prostatectomy VUAS data to understand the treatment pathway and provide higher‐quality evidence‐based care.
On threshold effect of housing finance on shared prosperity: Evidence from sub‐Saharan Africa
Authors: Nguena Christian Lambert , Tchana Tchana Fulbert , Zeufack Albert 
Published: July 2023

AbstractApplying panel threshold regression technics along with alternative econometric investigation on a panel database of 48 sub‐Saharan African (SSA) countries over the period 2000–2012, this paper analyzes the structure of housing finance in SSA countries and mainly verifies if there is a threshold effect on shared prosperity. Independently of the method used, our findings offer strong evidence of an inverted U‐shaped relationship between housing finance and inequality. The current level of development of housing finance in SSA, which is at its very early stage, is not yet an effective tool for reducing economic inequality; however, beyond a given threshold, housing finance becomes effective in reducing inequality. Indeed, higher values of housing finance depth above a certain threshold of 6.35% reduce inequality, whereas values below 6.35% and very high values have no significant impact. In addition, there is a slightly positive relationship between housing finance and labor productivity growth in SSA. Results also show that the way housing finance impact inequality is highly dependent on their ability to implement effective crisis fight policies. Controlling for countries’ income levels, legal origin, and regional proximity revealed relative benchmarking, typology, and characteristics of SSA housing finance. These findings suggest some policies to stimulate the development of housing finance in SSA. As a bonus, this paper also highlights several other pillars that can be used to support shared prosperity in SSA.
Pamoic acid‐induced peripheral GPR35 activation improves pruritus and dermatitis
Authors: Kim Chaeeun , Kim Yerin , Lim Ji Yeon , Kim Minseok , Zheng Haiyan , Kim Miri , Hwang Sun Wook 
Published: July 2023

AbstractBackground and PurposePruritic dermatitis is a disease with a considerable unmet need for treatment and appears to present with not only epidermal but also peripheral neuronal complications. Here, we propose a novel pharmacological modulation targeting both peripheral dorsal root ganglion (DRG) sensory neurons and skin keratinocytes. GPR35 is an orphan G‐protein‐coupled receptor expressed in DRG neurons and has been predicted to downregulate neuronal excitability when activated. Modulator information is currently increasing for GPR35, and pamoic acid (PA), a salt‐forming agent for drugs, has been shown to be an activator solely specific for GPR35. Here, we investigated its effects on dermatitic pathology.Experimental ApproachWe confirmed GPR35 expression in peripheral neurons and tissues. The effect of PA treatment was pharmacologically evaluated in cultured cells in vitro and in in vivo animal models for acute and chronic pruritus.Key ResultsLocal PA application mitigated acute non‐histaminergic itch and, consistently, obstructed DRG neuronal responses. Keratinocyte fragmentation under dermatitic simulation was also dampened following PA incubation. Chronic pruritus in 1‐chloro‐2,4‐dinitrobenzene and psoriasis models were also moderately but significantly reversed by the repeated applications of PA. Dermatitic scores in the 1‐chloro‐2,4‐dinitrobenzene and psoriatic models were also improved by its application, indicating that it is beneficial for mitigating disease pathology.Conclusion and ImplicationsOur findings suggest that pamoic acid activation of peripheral GPR35 can contribute to the improvement of pruritus and its associated diseases.
Praeruptorin A inhibits the activation of NF‐κB pathway and the expressions of inflammatory factors in poly (I:C)‐induced RAW264.7 cells
Authors: Hu Jiayan , Liu Roujun , Yang Zhouxin , Pan Xinyu , Li Yuanjing , Gong Yanghui , Guo Dongyang 
Published: July 2023

AbstractPraeruptorin A (PA), a natural coumarin compound, has significant anti‐inflammatory effects. In this study, we evaluate the anti‐inflammatory effect of PA on RAW 264.7 mouse macrophages induced by Polyinosinic acid‐polycytidylic acid (poly (I:C)). RAW 264.7 mouse macrophages induced by poly (I:C) were treated with or without PA, the viability of which was determined to screen working solution of PA. RNA‐sequencing was applied to analyze the differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were carried out. The expressions of interleukin (IL)‐1β, heme oxygenase 1 (HMOX1), prostaglandin‐endoperoxide synthase 2 (PTGS2), ATP binding cassette subfamily A member 1 (Abca1) and NF‐κB‐related proteins were measured by enzyme‐linked immunosorbent assay (ELISA), quantitative reverse transcription polymerase chain reaction (qRT‐PCR) and western blot. As a result, PA at 1, 2, 3, 4 and 5 μM slightly affected cell viability, while PA at 6 and 7 μM significantly inhibited cell viability. GO and KEGG analysis results revealed that DEGs were mainly enriched in the pathways related to inflammatory signaling. Through further analysis, we obtained five possible targets of PA, and verified that PA inhibited the expressions of IL‐1β, HMOX1, PTGS2 and Abca1 as well as the activation of NF‐κB pathway in poly (I:C)‐induced RAW264.7 cells. To summarize, PA may inhibit expressions of the inflammation‐related genes in poly (I:C)‐induced RAW264.7 cells, which demonstrates its potential as a drug against virus related diseases.
Genetic and phenotypic diversities of nevus spilus phenotypes: Case series and a proposed diagnostic algorithm
Authors: Zhang Jia , Xu Qianyue , Deng Dan 
Published: July 2023

AbstractNevus spilus (NS) is composed of multiple types that characterized by a congenital hyperpigmented patch within variable even superimposed lesions originating from melanocytic lineage cells. The molecular mechanism and classification of diverse NS phenotypes remain unclear. Five children with a phenotype of NS were genotyped by the panel based on next‐generation sequencing in this study. DNA from biopsies, blood samples and hair follicle were sequenced to confirm the presence of a somatic mutation. Sequencing results indicated somatic mutation in the gene of NRAS or HRAS in all biopsies from the nevi, and the pathogenic variants were not detected in the samples of blood and hair follicle. This study successfully identified the somatic mutation in five unrelated children with diverse NS phenotypes. Moreover, it provided typical images and differential diagnoses between variable NS phenotypes in clinical, pathological, and genetic features, and first proposed a clinical diagnostic algorithm that contributed to simplifying and optimizing the diagnoses and management of these overlapped diseases.
Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org
Authors: Taylor Zachary L. , Miller Tamara P. , Poweleit Ethan A. , DeGroote Nicholas P. , Pommert Lauren , Awoniyi Oluwafunbi , Board Sarah G. , Ugboh Ngozi , Joshi Vivek , Ambrosino Nick , Chavana Ashley , Bernhardt Melanie B. , Schafer Eric S. , O'Brien Maureen M. , Castellino Sharon M. , Ramsey Laura B. 
Published: July 2023

AbstractThe MTXPK.org webtool was launched in December 2019 and was developed to facilitate model‐informed supportive care and optimal use of glucarpidase following the administration of high‐dose methotrexate (HDMTX). One limitation identified during the original development of the MTXPK.org tool was the perceived generalizability because the modeled population comprised solely of Nordic pediatric patients receiving 24‐h infusions for the treatment of acute lymphoblastic leukemia. The goal of our study is to describe the pharmacokinetics of HDMTX from a diverse patient population (e.g., races, ethnicity, indications for methotrexate, and variable infusion durations) and identify meaningful factors that account for methotrexate variability and improve the model's performance. To do this, retrospectively analyzed pharmacokinetic and toxicity data from pediatric and adolescent young adult patients who were receiving HDMTX (>0.5 g/m2) for the treatment of a cancer diagnosis from three pediatric medical centers. We performed population pharmacokinetic modeling referencing the original MTXPK.org NONMEM model (includes body surface area and serum creatinine as covariates) on 1668 patients, 7506 administrations of HDMTX, and 30,250 concentrations. Our results support the parameterizations of short infusion duration (<8 h) and the presence of Down syndrome on methotrexate clearance, the parameterization of severe hypoalbuminemia (<2.5 g/dL) on the intercompartmental clearance (Q2 and Q3), and the parameterization of pleural effusion on the volume of distribution (V1 and V2). These novel parameterizations will increase the generalizability of the MTXPK.org model once they are added to the webtool.
Perioperative antibiotic prophylaxis in skin surgery – Position paper of the Antibiotic Stewardship working group of the German Society for Dermatologic Surgery (DGDC), Part 2: Special indications and situations
Authors: Balakirski Galina , Becker Sören L. , Hartmann Daniela , Kofler Lukas , Kunte Christian , Müller Cornelia S. L. , Volz Thomas , Kendziora Benjamin , Schlager Justin Gabriel , Löser Christoph R. 
Published: July 2023

SummaryIn addition to prevention of surgical site infections after skin surgery, perioperative antibiotic prophylaxis (PAP) aims to prevent the occurrence of other postoperative infectious complications, especially bacterial endocarditis and hematogenous joint prosthesis infections. This article discusses specific indications for the use of PAP. For example, patients who have undergone any type of heart valve replacement, including transcatheter valve replacement or use of prosthetic material to correct the heart valve, or patients who have experienced bacterial endocarditis, require PAP during skin surgery on mucosal membranes or ulcerated tumors.The use of PAP in special situations such as secondary wound healing, septic dermatosurgery or ulcer surgery is also presented and discussed in detail in this paper based on the current scientific literature. This paper represents the second part of the position paper of the Antibiotic Stewardship Working Group of the German Society for Dermatologic Surgery (DGDC) and summarizes evidence‐based recommendations for the administration of PAP during skin surgery for special indications and situations. This is particularly important because, as detailed in Part 1 of this position paper, PAP can and usually should be avoided in skin surgery.