bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Learning Solution for Real-time Quality Assessment and Control in Additive Manufacturing Using Point Cloud Data
Authors: Akhavan Javid , Lyu Jiaqi , Manoochehri Souran 
Published: February 2023

Abstract
This work presents an in-situ quality assessment and improvement technique using point cloud and AI for data processing and smart decision making in Additive Manufacturing (AM) fabrication to improve the quality and accuracy of fabricated artifacts. The top surface point cloud containing top surface geometry and quality information is pre-processed and passed to an improved deep Hybrid Convolutional Auto-Encoder decoder (HCAE) model used to statistically describe the artifact's quality. The HCAE’s output is comprised of 9*9 segments, each including four channels with the segment's probability to contain one of four labels, Under-printed, Normally-printed, Over-printed, or Empty region. This data structure plays a significant role in command generation for fabrication process optimization. The HCAE’s accuracy and repeatability were measured by a multi-label multi-output metric developed in this study. The HCAE’s results are used to perform a real-time process adjustment by manipulating the future layer's fabrication through the G-code modification. By adjusting the machine's print speed and feed-rate, the controller exploits the subsequent layer’s deposition, grid-by-grid. The algorithm is then tested with two defective process plans: severe under-extrusion and over-extrusion conditions. Both test artifacts' quality advanced significantly and converged to an acceptable state by four iterations.
Ibrutinib versus bendamustine plus rituximab for first-line treatment of older patients with untreated chronic lymphocytic leukemia without del(17p)/TP53 mutation in China: A lifetime economic research study
Authors: Hong Yuan , Chen Xichuang , You Xiaohong , Wang Yan , Hong Yuanquan , Mi Jingyi , Xiao Xingfang , Zhou Tao , Zheng Panpan , Huang Zhihu 
Published: February 2023

Abstract
Background
The incidence and mortality rates of patients with chronic lymphocytic leukemia (CLL) in China have recently increased. This study performed a long-term economic evaluation of the first-line treatment strategies ibrutinib (IB) or bendamustine (BE) plus rituximab (RI) for previously untreated older patients with CLL without the del(17p)/TP53 mutation in China.
Methods
Based on clinical data from large, randomized trials, a Markov model including four disease states (event-free survival, treatment failure, post-treatment failure, and death) was used to estimate the incremental costs per quality adjusted-life year (QALY) gained from the first-line IB strategy versus the BE plus RI strategy over a 10-year period. All costs were adjusted to 2021 values based on the Chinese Consumer Price Index, and all costs and health outcomes were discounted at an annual rate of 5%. Sensitivity analysis was performed to confirm the robustness of base-case results.
Results
Compared to the first-line BE plus RI strategy, first-line IB treatment achieved 1.17 additional QALYs, but was accompanied by $90,843.67 (estimated in 2021 US dollars) in decremental costs per patient over 10 years. Thus, first-line treatment with IB appeared to have absolute dominance compared to the BE plus RI strategy. Sensitivity analysis confirmed the robustness of these results.
Conclusions
From the perspective of the Chinese health care system, first-line treatment with IB is absolutely cost-effective compared to the first-line BE plus RI strategy for the treatment of older patients with CLL without the del (17p)/TP53 mutation. Therefore, we strongly recommend that Chinese health authorities select the former strategy for these CLL patients.
NudCL2 is essential for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
Authors: Xu Xiaoyang , Huang Yuliang , Yang Feng , Sun Xiaoxia , Lin Rijin , Feng Jiaxing , Yang Mingyang , Shao Jiaqi , Zhou Tianhua , Yang Yuehong 
Published: February 2023

Abstract
Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter cells. However, its underlying mechanism remains elusive. Here, we show that an Hsp90 co-chaperone NudC-like protein 2 (NudCL2) regulates cytokinesis by stabilizing regulator of chromosome condensation 2 (RCC2) in mammalian cells. NudCL2 co-localizes with RCC2 at the midbody and is required for RCC2 stabilization. Either NudCL2 knockout (KO) or RCC2 depletion causes similar phenotypes, including cytokinesis failure, midbody disorganization, and multinucleation. Ectopic expression of RCC2 effectively reverses the cytokinesis defect induced by NudCL2 KO. Furthermore, Hsp90 is also found to co-localize with NudCL2 at the midbody and is involved in NudCL2-mediated RCC2 stability and cytokinesis. Interestingly, our results reveal that the mRNA and newly synthesized peptides of RCC2 accumulate at the midbody. Loss of NudCL2 decreases the nascent RCC2, but not RCC2 mRNA, at the midbody. Taken together, our data provide a previously undescribed mechanism showing that NudCL2/Hsp90/RCC2 pathway is essential for cytokinesis at the midbody.
How does personalized feedback on carbon emissions impact intended climate action?
Authors: Luo Yu , Hanson-Wright Brynley , Dowlatabadi Hadi , Zhao Jiaying 
Published: February 2023

Abstract
Carbon emissions associated with individual choices are difficult to conceptualize and seldom considered in daily decision making. We examine the impact of personalized feedback on carbon emissions on intended climate action. In a pre-registered experiment (N=790), participants reported their consumption in 2019 and received personalized feedback on carbon emissions and recommendations for reduction in the feedback condition, or no feedback in the control condition. Subsequently, all participants indicated their consumption intentions in 2023, which was one year from the year the experiment was conducted. After receiving feedback, participants showed a significant emission reduction of 1.42tCO2e (-12.60%) per capita between 2019 and 2023, whereas those in the control condition increased their emissions by 0.05tCO2e (+0.045%). Importantly, there was no impact on intentions to engage in civic climate action. Civic climate intentions were instead associated with eco-guilt and climate concerns. These findings suggest personalized feedback has the potential to reduce carbon emissions without impacting civic climate intentions, providing implications for strategies to encourage climate action.
Deep transfer learning radiomics based on two-dimensional ultrasound for predicting the efficacy of neoadjuvant chemotherapy in breast cancer
Authors: Wang Zhan , Zhao Tong , Zhang Heng , Zhang Chao , Duan Tongtong , Li Xiaoqin , Xu Lingyun 
Published: February 2023

Abstract
Purpose
We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep migration learning, and clinical features for pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for the breast cancer.
Methods
We enrolled 211 patients with pathologically confirmed the breast cancer who underwent NAC. The patients were randomly divided into the training set and the validation set in the ratio of 7:3. The deep learning and radiomics features of pre-treatment ultrasound images were extracted, and the random forest recursive elimination algorithm and the least absolute shrinkage and selection operator were used for feature screening and DL-Score and Rad-Score construction. According to multiple logistic regression, independent clinical predictors, DL-Score, and Rad-Score were selected to construct the comprehensive prediction model DLR + C. The performance of the model was evaluated in terms of its predictive effect, calibration ability, and clinical practicability.
Result
Compared to the clinical, radiomics (Rad-Score), and deep learning (DL-Score) models, the DLR + C accurately predicted the pCR status, with an area under the curve (AUC)of 0.906 (95% CI: 0.871–0.935) in the training set and 0.849 (95% CI: 0.799–0.887) in the validation set, with good calibration ability (Hosmer-Lemeshow: P > 0.05). Moreover, decision curve analysis confirmed that the DLR + C had the highest clinical value among all models.
Conclusion
The comprehensive model DLR + C based on ultrasound radiomics, deep transfer learning, and clinical features can effectively and accurately predict the pCR status of breast cancer after NAC, which is conducive to assisting clinical personalized diagnosis and treatment plan.
Comparative seasonal analysis of Eri silkworm (Samia ricini Donovan) gut composition: implications for lignocellulose degradation
Authors: Gogoi Parishmita , HatiBaruah Jyoti L , Yadav Archana , Debnath Rajal , Saikia Ratul 
Published: February 2023

Abstract
Conversion of biomass such as lignocelluloses to alternative energy source can contribute to sustainable development. Recently, biomass degrading enzymes are reported to be common resources in insect-microbe interacting systems. North-East India harbours ample sericigenous insect resources which are exploited for their silk products. Samia ricini Donovan is an economically important poly-phytophagous silkmoth capable of digesting foliage from different plant species, suggesting versatility of robust gut system. Here, gut bacterial profile was determined by 16S rRNA gene characterization across the holometabolous life cycle during summer and winter seasons revealing 3 phyla, 13 families and 22 genera. Comparative analysis among the seasonal gut isolates revealed a high diversity in summer, predominated by genus Bacillus due to its high occurrence in all developmental stages. Shannon’s diversity index demonstrated second and fourth instars of summer as well as fifth instar of winter to be relatively better developmental stages for gut bacteria assemblance. Bacterial community shifts in concert to host developmental changes were found to be apparent between early instars and late instars in summer which differs from those of winter. Forty-three and twenty-nine gut isolates were found to be a potential cellulolytic and xylanolytic enzyme producers. Our results illustrates gut microbiota of S .ricini over the seasons and support holometabolous life cycle effect as the more likely factor shaping gut bacterial microbiota. These findings may provide leads for development of new cleaner and environment friendly lignocelluloses degrading enzymes.
Perceptions of people living with human immunodeficiency virus regarding the use of dolutegravir based regimen, Limpopo Province
Authors: Sibeko Zandile Rachel , Molato Boitumelo Joy , Moloko-Phiri Salaminah 
Published: February 2023

Abstract
Background
HIV and AIDS continue to be a public health concern with Sub-Saharan Africa having the highest number of HIV incidences. Progress towards management of the disease has been implemented over the years and antiretroviral therapy has been a great achievement. The World Health Organisation recommended dolutegravir as the second line of treatment for the disease. Literature explains DTG based regimen as having great outcomes although it was discovered to have unpleasant side effects on some patients. The objective was to explore and describe perceptions of PLWHA regarding the use of dolutegravir based regimen in Limpopo province.
Method
A qualitative, explorative-descriptive design was followed. Individual semi-structured in-depth interviews were conducted. Purposive sampling was used until data saturation was reached. Thematic analysis was used, and the following themes generated: Acceptance of dolutegravir, level of knowledge regarding dolutegravir, the burden of knowledge regarding dolutegravir, the burden of taking ART treatment, the reasons for non-adherence to dolutegravir.
Results
The findings revealed great acceptance of DTG. The importance of taking treatment was mentioned although some participants lacked knowledge.
UV filters in everyday cosmetic products, a comparative study
Authors: Couteau Céline , Philippe Anne , Galharret Jean-Michel , Metay Emilie , Coiffard Laurence 
Published: February 2023

Abstract
Today, UV filters are found as contaminants in a variety of biological fluids and environment, e.g. in vegetable crops and surface water. This is because UV filters are widely used in everyday products. In this context, we focused this study on cosmetic products. The study of 742 cosmetic products, excluding actual sunscreen products, but including hygiene, personal care and make-up products and perfumes revealed that the most common UV filters present are butyl methoxydibenzoylmethane, octyl methoxycinnamate, octocrylene, octyl salicylate and titanium dioxide. Few UV filters are found in the hygiene products and deodorants and toothpastes are completely free of them. Conversely, make-up and perfumes are frequently formulated with at least one UV filter.
Phenomenological Description of the acidityof the Citric Acid and its DeprotonatedSpecies: Informational-Theoretical Study
Authors: Vazquez-Hernandez Hazel , Esqu Rodolfo O 
Published: February 2023

Abstract
Context
In spite of the fact that molecular acidity is a fundamental physicochemical property of molecular systems, the vast majority of theoreticalstudies have focused attention on monoprotic acids and on the prediction of pKa’s. Polyprotic acids, represent a challenge for electronicstructure calculations since the multiple acidic sites result in a vastgroup of species with different conformations and reactivities. In thiswork, Information-theoretic (IT) concepts of localizability, order anduniformity are applied to the Citric Acid and its deprotonated speciesthrough the one-electron density functionals: Shannon entropy (S),Fisher information (I) and disequilibrium (D), respectively. We pursuethe goal of characterizing the acidity of the aforementioned species withthe aim to associate the IT concepts to chemical features such as thepolarizability of the protonated/deprotonated species, the liability ofthe acidic sites, atomic electrostatic potentials, covalent bonding. ITanalyses looks very promising for future studies on the acidity of specificdeprotonation-sites of polyprotic acids.
Methods
Density functional theory (DFT) calculations were performed with Gaussian 09 program. A sensitivity analysis of the IT-measures was performed for the citric acid and the citrate using B3LYP, B3PW91, BPW91, M05-2X, M06-2X and PBEPBE functionals with the 6-311++g(3df,2p), 6-311++g(d,p), 6.311+g(d,p) and aug-cc-pVDZ basis sets. The rest of the analysis was performed with the M05-2X/6-311+G(d,p) level of theory. Additionally, aqueous media was considered by use of the SMD solvent model. The IT-measures were calculated using a suite of programs developed in our laboratory jointly with the DGRID software package.
Structural Modulation of Low-Cost Cu-Mn-Fe Prussian Blue Analogs for Long-Calendar-Life Sodium Ion Batteries
Authors: Gao Yun , Zhang Hang , Wang Jinsong , Peng Jian , Xiao Yao , Liu Yang , Yun Qiao , Li Li , Wang Jia-zhao , Chou Shulei 
Published: February 2023

Abstract

High electrochemical-performance and cost-efficient cathodes are crucial for the development of grid-scale sodium-ion batteries (SIBs). Prussian blue analogs (PBAs) are generally regarded as promising cathode candidates for SIBs, although their practical application has been limited by low capacity or poor cycling ability caused by their poor crystallinity and reversibility. Herein, a series of low-cost and high-quality ternary PBAs are prepared by structural regulation to simultaneously achieve high capacity, stable cyclability, and wide temperature suitability. The prepared CuHCF-3 sample has delivered a high specific capacity of 132.4 mAh g-1 with 73.3% capacity retention over 1000 cycles when applied as a cathode material for SIBs. A highly reversible three phase (monoclinic to cubic to tetragonal) sodium-ion storage mechanism is revealed via multiple in-situ techniques. Density functional theory calculations indicate that the key for achieving high capacity and long lifespan lies in the synergistic effect of Mn and Cu in the crystal structure of PBAs. The presence of Mn could enhance electronic conductivity, improve the operating voltage, and provide more possible redox centers while the presence of Cu-ions can restrain the Jahn-Teller distortions and buffer huge volume expansion during cycling. Furthermore, the wide-temperature suitability of these materials and Na-ion full cells are investigated based on kilogram-scale production as a demonstration for their practical application. We hope that this work can provide new insights into designing high-performance and low-cost electrode materials for practical grid-scale energy storage systems.
A Joint Optimization Scheme of Task Caching and Offloading for Smart Factories
Authors: Qu Xiaofeng , Wang Huiqiang 
Published: February 2023

Abstract
In the application scenario of the smart factory, the computing tasks of smart devices are intensive and the tasks are sensitive to delay. The smart device needs to offload the task to the edge server for execution. However, the computing resources of edge servers are limited and there will be workload imbalance among multiple edge servers. To solve these problems, we propose a joint optimization scheme of task caching and offloading based on task scene awareness, which decouples the joint optimization problem of task caching and offloading into two subproblems: task caching and task offloading. For the task caching subproblem, a bilateral auction task caching algorithm based on task scene awareness is proposed. For the task offloading subproblem, a task offloading algorithm based on task scenario offloading preferences is proposed. The experimental results show that the optimization scheme proposed in this paper has obvious performance advantages when the number of tasks is large and the number of intelligent devices is large. This scheme also achieves workload balancing among multiple edge servers.
Anti-ganglioside antibody positive neuromyelitis optica spectrum disease with peripheral neuropathy: a case report
Authors: Li Yangchun , Tang Man , Yu Lu , He Ying , Liang Lisong , Qu Hao , Si Wei , Hu Xiao 
Published: February 2023

Abstract
Background
Neuromyelitis optica spectrum disease (NMOSD) is a demyelinating disease of the central nervous system primarily involving the optic nerve and spinal cord. There are limited reports of NMOSD associated with peripheral nerve damage.
Case presentation
We report a 57-year-old female patient who met the diagnostic criteria for aquaporin-4 (AQP4) IgG-positive NMOSD with undifferentiated connective tissue disease andmultiple peripheral neuropathy. In addition, the patient was positiveformultiple anti-ganglioside antibodies (anti-GD1a IgG antibodies and anti-GD3 IgM antibodies) and anti-sulfatide IgG antibodies in serum and cerebrospinal fluid. After treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab, the patient’s status improved and was subsequently discharged from our hospital.
Conclusions
The neurologist should be aware of the unusual association between NMOSD and immune-mediated peripheral neuropathy. Undifferentiated connective tissue disease and nerve damage mediated by multiple antibodies may have combined to cause peripheral nerve damage in this patient.
Pathological biomarkers predict recurrence and metastasis in patients with lacrimal gland adenoid cystic carcinoma
Authors: Zhou Xiaowen , Feng Yiyi , Yang Yidi , Li Shuai , Zong Chunyan , Yu Yilin , Zhu Tianyu , Shi Jiahao , Jia Renbing , Fan Xianqun , Chen Huifang , Li Yimin , Song Xin 
Published: February 2023

Abstract
Background
Lacrimal gland adenoid cystic carcinoma is the most common lacrimal gland malignant epithelial tumour, characterized by high rates of relapse and distant spread. As few studies have reported pathological biomarkers for LGACC, we aimed to identify biomarkers that can predict the recurrence and metastasis of LGACC.
Methods
Twenty-eight patients diagnosed with LGACC between 2008 and 2022 were included. The level of expression of ASCT2, GLS1, MCT4, and SHMT1 in patients with LGACC was evaluated by immunohistochemistry and the concordance was calculated. Patients were divided into negative and positive groups according to the staining results of ASCT2, and high or low expression groups according to the staining scores of GLS1, MCT4, and SHMT1. The recurrence-free survival, metastasis-free survival, and overall survival were analysed and compared between groups.
Results
The study participants comprised 16 males and 12 females, with a median age of 52.4 years (range: 30–77 years). During a 34.3-month median follow-up (range: 0.4–125.1 months), 7 (25%) patients suffered recurrence, 8 (28.6%) patients had metastasis, and 4 (14.3%) patients died due to LGACC. Patients with negative ASCT2 expression had a significantly shorter recurrence-free survival (p = 0.007), metastasis-free survival (p = 0.033), and poorer overall survival (p = 0.028). Multivariate analysis showed that ASCT2 was an independent risk factor for disease recurrence (HR = 0.1, 95% CI: 0.012–0.88, p = 0.038).
Conclusions
ASCT2 negative expression is a predictor to identify patients with poor recurrence-free survival, metastasis-free survival, and overall survival.
Spinal Epidural Electrical Stimulation for recovery of motor function in lower limbs after Spinal Cord Injury: A Phase I/II clinical trial
Authors: Chhabra Harvinder , Varma Kalidindi Kalyan Kumar , Garg Nikhil , Sharma Ankit , Chibber Bhumika , Kumar Hitesh , Vishwakarma Gayatri , Sharma Navita , Sharma Ridhi , Gupta Mayank , Bhat Mohd Rafiq 
Published: February 2023

Abstract
Study design:
Single-arm prospective phase I/II clinical trial
Objective:
Standing and walking are highly desirable goals forpersons with spinal cord injury (SCI). Spinal epidural electrical stimulation (sEES) has been utilized to produce rhythmic activity in animals and more recently, in a few human case reports. Our objective was to assess the safety and efficacy of sEES in the recovery of motor function after severe SCI.
Setting:
Indian Spinal Injuries Center, New Delhi
Methods:
Fiveparticipantssatisfying the eligibility criteria includingsevere and chronic SCIand an absence of useful power in the lower limbswere included in the study. The Institute Ethics Committee and the Research Review Committee approved the study and it was registered with Clinical Trials Registry of India.
Results:
No intraoperative or early postoperative complications were noted in any of the participants. Two participants had wound complicationsat 1 and 3 months respectively and were managed successfully.Improvement in the voluntary power of lower limbs, motor abilities, and functional recoverywas noted in the majority of the participants when the sEESwas turned on. Even with sEES turned off; there was improvement in motor abilities of a participant though there was no demonstrable neurological recovery.
Conclusions:
sEES is a safe intervention and improves the motor and functional abilities of persons with severe and chronic SCI. Neurological recovery could not be demonstrated. However, a larger,prospective,matched controlledstudy with more participants needs to be done to draw a definite conclusion.