bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Resiliensi Matematis Terhadap Kemampuan Pemecahan Masalah Siswa kelas VIII Sekolah Menengah Pertama
Authors: Olo Elisabeth , Son Aloisius Loka , Klau Kondradus Yohanes 
Published: September 2023

Resiliensi matematis dapat membantu siswa untuk memecahkan masalah matematis. Siswa yang memiliki keterampilan resiliensi matematis tinggi akan mampu memecahkan masalah matematika. Karena itu, dilakukan penelitian ini untuk mengetahui pengaruh resiliensi matematis terhadap kemampuan pemecahan masalah siswa sekolah menengah pertama. Penelitian ini merupakan penelitian kuantitatif, dengan metode penelitian ex-post facto. Partisipan penelitian ini adalah siswa kelas VIII pada salah satu sekolah menengah pertama di Kabupaten Timor Tengah Utara. Semua populasi dijadikan sampel penelitian yang berjumlah 50 siswa. Instrumen penelitian ini adalah soal tes untuk mengukur kemampuan pemecahan masalah matematika, dan angket untuk mengukur resiliensi matematis siswa. Analisis data menggunakan statistik parametrik berupa uji regresi. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh resiliensi matematis terhadap kemampuan pemecahan masalah siswa, dengan besar pengaruhnya adalah 85%, dan persamaan regresinya adalah . Direkomendasikan kepada guru matematika agar memfasilitasi resiliensi matematis siswa sehingga dapat memecahkan masalah matematika yang dihadapi.
padres opinan sobre la formación. La voz del imaginario colectivo
Authors: Angulo Villanueva Rita Guadalupe , Moreno Martínez Nehemías , Pérez García Edgar Alfonso 
Published: September 2023

Sobre el supuesto de que está surgiendo en el imaginario social un ideal formativo distinto (código curricular emergente) para las nuevas generaciones, nos preguntamos sí ¿los curricula deben ser modificados? Nuestro propósito es buscar el imaginario sobre la formación de las nuevas generaciones. Realizamos una investigación cualitativa mediante estudio de casos e interpretación por teoría fundamentada. Hemos seleccionado como población objetivo a los profesionistas, los estudiantes universitarios, los trabajadores en oficios diversos y los maestros, todos ellos padres de familia. En este texto presentamos el segundo sondeo que hemos levantado solamente con padres de familia; en sondeos posteriores se levantarán datos con los otros grupos poblacionales. Este sondeo se apoya en la categorización teórica elaborada previamente (Angulo, 2022) y el primer acercamiento mediante entrevistas a profundidad (Angulo, Moreno y Aguiñaga, 2022). En está ocasión, se aplicó un cuestionario con respuestas cerradas a 28 personas y una sola pregunta de respuesta abierta; se organizó en cuatro secciones (1ª correo, 2ª datos generales, 3ª rasgos de la formación, 4ª cuidarse a sí mismo, a los demás y convivir). La última sección fue identificada en el primer acercamiento como el rasgo formativo más importante para los informantes entrevistados. En este levantamiento vuelve a mostrarse como el rasgo formativo esencial para los padres encuestados. Los resultados muestran que los curricula escolares, incluidos los universitarios, requieren ser reformulados a fin de brindar una formación integral que, si bien se ofrece en el nivel educativo de preescolar paulatinamente se difumina en favor de una formación más disciplinar y sin que este tipo de formación deje de ofrecerse, el rasgo formativo fundamental habrá de ser la formación para la vida, el cuidado de sí y el aprendizaje para vivir y convivir. Aparece también, el interés por contenidos útiles en la cotidineidad y que la escuela no ofrece.
Resiliensi Matematis Siswa SMP pada Pembelajaran Matematika Secara Daring
Authors: Nuraini Aisyah , Hakim Dori Lukman 
Published: September 2023

Sikap positif dalam pembelajaran matematika adalah bagian yang begitu penting dan harus ada dalam diri siswa karena dapat mengurangi hambatan yang dihadapi saat pembelajaran berlangsung. Wabah covid-19 telah merubah semua bidang, termasuk aspek pendidikan. Guru maupun siswa dituntut untuk melakukan pembelajaran secara daring, hal ini tentunya berpengaruh terhadap resiliensi matematis siswa. Oleh karena itu, artikel ini mempunyai tujuan untuk mendeskripsikan resiliensi matematis siswa SMP pada pembelajaran matematika secara daring. Penggunaan metode dalam artikel ini adalah deskriptif kualitatif dengan instrumen yang digunakan adalah instrumen non tes berupa angket berjumlah 30 butir pernyataan yang dapat ditanggapi oleh siswa melalui skala likert dengan rentang poin 1 sampai 5. Subjek yang diambil merupakan siswa kelas IX pada salah satu SMP di Kabupaten Karawang. Dari hasil analisis yang telah dilakukan, siswa masih mampu mengatasi kendala-kendala teknis saat pembelajaran berlangsung. Namun kendala siswa terletak pada tingkat pemahaman dan kurangnya inovasi guru dalam penyampaian materi yang hanya berpaku pada buku saja sehingga perlu adanya pengembangan baik dari segi model pembelajaran maupun bentuk materi yang disampaikan.
Is endoscopic sinus surgery sufficient to modify the evolution of adult AERD? Aspirin desensitization as a maintenance factor: systematic review
Authors: Conti Diego M. , Correa Eduardo J. , Scadding Glenis K. 
Published: September 2023

IntroductionAspirin desensitization (AD) and aspirin therapy after desensitization (ATAD) are therapeutic interventions for patients with aspirin-exacerbated respiratory disease (AERD). Our aim is to investigate whether its addition to endoscopic sinus surgery (ESS) improves the overall prognosis of the disease.MethodsA systematic review of the current literature including adult patients with a positive diagnosis of AERD undergoing endoscopic sinus surgery (ESS) in the context or in absence of upper airway comorbidity, prior to AD + ATAD.ConclusionThis review concludes that the surgical approach is beneficial in AERD, but its effects are short—lived. Surgery should be considered initially with subsequent AD + ATAD in AERD patients, due to the sustained improvement achieved compared to those receiving ESS alone.
Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment
Authors: Wang Kai , Schriver Brian J. , Aschar-Sobbi Roozbeh , Yi Alex Y. , Feric Nicole T. , Graziano Michael P. 
Published: September 2023

Introduction: The development of patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offers an opportunity to study genotype-phenotype correlation of hypertrophic cardiomyopathy (HCM), one of the most common inherited cardiac diseases. However, immaturity of the iPSC-CMs and the lack of a multicellular composition pose concerns over its faithfulness in disease modeling and its utility in developing mechanism-specific treatment.Methods: The Biowire platform was used to generate 3D engineered cardiac tissues (ECTs) using HCM patient-derived iPSC-CMs carrying a β-myosin mutation (MYH7-R403Q) and its isogenic control (WT), withal ECTs contained healthy human cardiac fibroblasts. ECTs were subjected to electro-mechanical maturation for 6 weeks before being used in HCM phenotype studies.Results: Both WT and R403Q ECTs exhibited mature cardiac phenotypes, including a lack of automaticity and a ventricular-like action potential (AP) with a resting membrane potential &lt; −75 mV. Compared to WT, R403Q ECTs demonstrated many HCM-associated pathological changes including increased tissue size and cell volume, shortened sarcomere length and disorganized sarcomere structure. In functional assays, R403Q ECTs showed increased twitch amplitude, slower contractile kinetics, a less pronounced force-frequency relationship, a smaller post-rest potentiation, prolonged AP durations, and slower Ca2+ transient decay time. Finally, we observed downregulation of calcium handling genes and upregulation of NPPB in R403Q vs. WT ECTs. In an HCM phenotype prevention experiment, ECTs were treated for 5-weeks with 250 nM mavacamten or a vehicle control. We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD90 prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.Discussion: Taken together, we demonstrated R403Q ECTs generated in the Biowire platform recapitulated many cardiac hypertrophy phenotypes and that chronic mavacamten treatment prevented much of the pathology. This demonstrates that the Biowire ECTs are well-suited to phenotypic-based drug discovery in a human-relevant disease model.
Comprehensive evaluation of time-varied outcomes for invasive and conservative strategies in patients with NSTE-ACS: a meta-analysis of randomized controlled trials
Authors: Zhao Yi-Jing , Sun Yangyang , Wang Fan , Cai Yuan-Yuan , Alolga Raphael N. , Qi Lian-Wen , Xiao Pingxi 
Published: September 2023

BackgroundResults from randomized controlled trials (RCTs) and meta-analyses comparing invasive and conservative strategies in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) are highly debatable. We systematically evaluate the efficacy of invasive and conservative strategies in NSTE-ACS based on time-varied outcomes.MethodsThe RCTs for the invasive versus conservative strategies were identified by searching PubMed, Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov. Trial data for studies with a minimum follow-up time of 30 days were included. We categorized the follow-up time into six varied periods, namely, ≤6 months, 1 year, 2 years, 3 years, 5 years, and ≥10 years. The time-varied outcomes were major adverse cardiovascular event (MACE), death, myocardial infarction (MI), rehospitalization, cardiovascular death, bleeding, in-hospital death, and in-hospital bleeding. Risk ratios (RRs) and 95% confidence intervals (Cis) were calculated. The random effects model was used.ResultsThis meta-analysis included 30 articles of 17 RCTs involving 12,331 participants. We found that the invasive strategy did not provide appreciable benefits for NSTE-ACS in terms of MACE, death, and cardiovascular death at all time points compared with the conservative strategy. Although the risk of MI was reduced within 6 months (RR 0.80, 95% CI 0.68–0.94) for the invasive strategy, no significant differences were observed in other periods. The invasive strategy reduced the rehospitalization rate within 6 months (RR 0.69, 95% CI 0.52–0.90), 1 year (RR 0.73, 95% CI 0.63–0.86), and 2 years (RR 0.77, 95% CI 0.60–1.00). Of note, an increased risk of bleeding (RR 1.80, 95% CI 1.28–2.54) and in-hospital bleeding (RR 2.17, 95% CI 1.52–3.10) was observed for the invasive strategy within 6 months. In subgroups stratified by high-risk features, the invasive strategy decreased MACE for patients aged ≥65 years within 6 months (RR 0.68, 95% CI 0.58–0.78) and 1 year (RR 0.75, 95% CI 0.62–0.91) and showed benefits for men within 6 months (RR 0.71, 95% CI 0.55–0.92). In other subgroups stratified according to diabetes, ST-segment deviation, and troponin levels, no significant differences were observed between the two strategies.ConclusionsAn invasive strategy is superior to a conservative strategy in reducing early events for MI and rehospitalizations, but the invasive strategy did not improve the prognosis in long-term outcomes for patients with NSTE-ACS.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289579, identifier PROSPERO 2021 CRD42021289579.
Effect of dual antiplatelet therapy prolongation in acute coronary syndrome patients with both high ischemic and bleeding risk: insight from the OPT-CAD study
Authors: Na Kun , Qiu Miaohan , Wei Ningxin , Li Jiayin , Yan Chenghui , Li Jing , Li Yi , Han Yaling 
Published: September 2023

BackgroundIn current clinical practice, controversy remains regarding the clinical benefits of prolonged dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients facing high risks of both ischemia and bleeding (“bi-risk”) following percutaneous coronary intervention (PCI). This study aimed to investigate the feasibility of identifying a group of bi-risk ACS patients after PCI using the OPT-BIRISK criteria, emphasizing extended DAPT treatment safety and efficacy beyond 12 months in these bi-risk ACS after PCI in real-world conditions.MethodsThis analysis compared extended DAPT and single antiplatelet therapy (SAPT) at 12–24 months in ACS patients undergoing PCI complicated with both ischemic and bleeding risk as defined by OPT-BIRISK criteria without premature DAPT discontinuation before 9 months or major clinical adverse events within 12 months. This was a post hoc analysis of the Optimal antiPlatelet Antiplatelet Therapy for Chinese Patients with Coronary Artery Disease (OPT–CAD) study. The main research outcome was the incidence of ischemic events within 12–24 months, which was determined as a composite of stroke, myocardial infarction, and cardiac death events. Through propensity score matching (PSM), groups were balanced. For the external validation of the OPT-BIRISK criteria to identify a bi-risk ACS patient, ischemic events, BARC 2, 3, 5 bleeding events, and BARC 3, 5 bleeding events at 5 years were analyzed.ResultsThe total number of ACS patients analyzed in this analysis was 7,049, of whom 4,146 (58.8%) were bi-risk patients and 2,903 (41.2%) were not. The frequency of ischemic events was significantly different between the two groups at 5 years (11.70% vs. 5.55%, P &lt; 0.001), and the incidence of BARC 2,3,5 bleeding was significantly higher in the bi-risk group (6.90% vs. 4.03%, P &lt; 0.001) than in the non-bi-risk group. Among the bi-risk patients without any clinical adverse events within 12 months that underwent extended DAPT treatment (n = 2,374, 75.7%) exhibited a lower risk of stroke at 12–24 months (1.10% vs. 2.10%, P = 0.036) relative to those that underwent SAPT (n = 763, 24.3%), while bleeding risk did not differ significantly between these groups. PSM cohort analysis results were consistent with those of overall group analyses.ConclusionIn conclusion, the findings showed that using the OPT-BIRISK criteria could help physicians identify ACS patients at a high risk of developing recurrent ischemia and bleeding episodes after PCI. Compared to antiplatelet monotherapy, a strategy of extended DAPT may offer potential benefits in lowering the risk of stroke without carrying a disproportionately high risk of serious bleeding problems among these patients who were event-free after a year of DAPT.
COVID-19-related school closures and mathematical performance—findings from a study with grade 3 students in Germany
Authors: Gasteiger Hedwig , Sachse Karoline A. , Schumann Kristoph , Gerve Mona , Schulz Axel , Engelbert-Kocher Maria 
Published: September 2023

IntroductionDue to the COVID-19 pandemic, measures were taken that had a considerable impact on the situation in schools. In Germany, these measures lasted more than a year and ranged from school closures and distance learning to alternating teaching phases with small groups. In the present study, we examined whether third-grade students’ mathematics performance changed in different content domains before and after the COVID-19-related changes in school.MethodsIn a repeated cross-sectional design, we compared two cohorts of third graders (2019: N = 1,905; 2021: N = 3,203) based on standardized mathematics tests, constructed according to the German National Educational Standards, which allowed for a differential competence diagnostic for five content domains. Generalized linear mixed models were used to model item and person properties and assess their effects on performance.ResultsThere was a significant drop in performance overall. While the drop in the content domain Numbers &amp; Operations was smaller than the overall drop in performance, the content domains Space &amp; Shape and Data, Frequency, Probability were more affected.DiscussionThe findings of this study may be explained by the results of numerous surveys of students, teachers, and parents, which indicated that a lot of time was spent on exercises and reproduction tasks during distance learning.
Sequential embryo transfer versus double cleavage-stage embryo or double blastocyst transfer in patients with recurrent implantation failure with frozen-thawed embryo transfer cycles: a cohort study
Authors: Gao Jiangman , Yuan Yifeng , Li Jia , Tian Tian , Lian Ying , Liu Ping , Li Rong , Qiao Jie , Long Xiaoyu , Wang Haiyan 
Published: September 2023

BackgroundRecurrent implantation failure (RIF) is more common among patients receiving assisted reproductive treatment. Many efforts have been made to increase the incidence of clinical pregnancy among patients with RIF. The effect of the sequential transfer procedure, a two-step interval transfer of a cleavage-stage embryo followed by a blastocyst in one transfer cycle, on the clinical outcomes of RIF patients remains controversial.MethodsIn total, 1774 frozen-thawed embryo transfer (FET) cycles in RIF patients were included. Of these cycles, 302 were sequential embryo transfer (ET) cycles, 979 were double day 3 cleavage-stage ET cycles, and 493 were double blastocyst ET cycles. The primary outcomes were the rates of implantation, clinical pregnancy and multiple pregnancy, and the secondary outcomes were the rates of hCG positive, early miscarriage and ectopic pregnancy.ResultsThe implantation, hCG positive, and clinical pregnancy rates in the sequential ET group (32.1%, 58.9%, 50.7%) were significantly higher than those in the day 3 cleavage-stage ET group (24.9%, 46.5%, 40.4%) and were similar to those in the blastocyst transfer group (30.1%, 56.4%, 47.1%). The early miscarriage rate in the blastocyst transfer group was significantly higher than that in the cleavage-stage ET group (17.2% vs. 8.1%, P &lt;0.05), while the ectopic pregnancy rate in the blastocyst transfer group was significantly lower than that in the cleavage-stage ET group (0.4% vs. 3.0%, P &lt;0.05). The multiple pregnancy rate in the sequential ET group was significantly lower than that in the cleavage-stage ET group (17.0% vs. 25.5%, P &lt;0.05) and the blastocyst transfer group (17.0% vs. 27.6%, P &lt;0.05). When cycles of blastocyst culture failure were excluded, the clinical pregnancy rate was significantly higher (55.7% vs. 47.1%, P &lt;0.05), and the early miscarriage rate and multiple pregnancy rate were significantly lower (8.5% vs. 17.2%, 17.7% vs. 27.6%; P &lt;0.05, respectively) in the sequential ET group than in the double blastocyst ET group.ConclusionsSequential embryo transfer in FET cycles could improve the clinical outcomes of patients with RIF.
Temperature-dependent feeding behavior in the brown box crab, Lopholithodes foraminatus
Authors: Moretto Wave I. , Taylor Jennifer R. A. 
Published: September 2023

IntroductionGrowing fishing pressures and ocean warming are potential concerns for populations of brown box crabs, Lopholithodes foraminatus, at the southern end of their geographic distribution. In Southern California, brown box crabs are thought to occupy a broad depth gradient (intertidal zone - 547 m), which exposes them to temperatures ranging from 8°C - 24°C. This large temperature span presents challenges for these ectothermic animals because the rates of their physiological processes, and ultimately their dietary needs, behavior, and health, vary with temperature. Here we examined how temperature affects the feeding behavior of brown box crabs to better understand their ecology in warmer regions of their distribution.MethodsAdult crabs were exposed to one of three temperature treatments (8°C, 15°C, and 20°C, N=10) for 2 months. Weekly throughout the exposure period, crabs were given two similar-sized prey items of different crushing strength (clam and mussel). Claw pinch force, prey preference, time to consume prey, and number of prey consumed were recorded prior to the start of the experiment and weekly for the duration of the study, with the exception of pinch force, which was recorded bi-weekly. We hypothesized that crabs will have a stronger pinch force at warmer temperatures, prefer prey items that require less breaking force at the coldest temperature, consume prey faster at warmer temperatures, and consume more prey at warmer temperatures.ResultsOur results confirm that pinch force is consistently greater at 15°C compared to 8°C, however, crabs at 8°C consumed more clams (higher strength) while those at 15°C consumed more mussels. Crabs at 8°C also consumed prey items faster than crabs at 15°C but ate a similar number of prey. Furthermore, there was 100% mortality at 20°C within 8 days of exposure, indicating their proximity to lethal limits within Southern California.DiscussionThese results show that brown box crab feeding behavior exhibits temperature thresholds, which may alter their nutritional state, community interactions, and distribution under both short-term and long-term changes in ocean temperature.
Effects of the particle morphology and volume fraction of coarse aggregate on the mechanical properties of concrete
Authors: Zhao Wei , Si Zheng , Du Xiaoqi , Huang Lingzhi 
Published: September 2023

The morphology and volume fraction of coarse aggregate particles significantly influence the mechanical characteristics of concrete. This paper presents the development of a numerical model for pebble concrete by combining experiments with the discrete element method. The mesoscopic parameters between mortars and the contact surface between mortars and aggregates in the model were calibrated by comparing simulated stress–strain relationships with experimental data from pebble concrete. Subsequently, the model and mesoscopic parameters were validated by comparing them with experimental results. The obtained mesoscopic parameters were then utilized in the numerical modeling of uniaxial compression for single-shaped coarse aggregate concrete. Results showed that the peak stress of the elliptical aggregate concrete was 2.8 MPa higher than that of the oblate spherical aggregate concrete, leading to more cracks and severe damage in the former. Thus, elliptical aggregates proved more suitable as coarse aggregates for concrete than oblate spherical aggregates. Furthermore, the study investigated the influence of ellipsoidal aggregate volume fraction on concrete strength. The compressive strength reached the highest when the volume fraction of ellipsoidal aggregate was 57%. Therefore, the ideal coarse aggregate volume fraction was determined to be 57%. These results offer valuable insights into designing concrete mix proportions.