bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Anthocyanin Extracted from Purple Sweet Potato and Nata de Coco Film in The Smart Food Packaging Technology
Authors: Ardiani Septia , Handika Rahmayanti Dany , Desvi Setiadi , Akmalia Nurul , Kartika Tipri Rose , Suryani Meuthia 
Published: September 2023

Chicken liver is one of the products consumed by the majority of Indonesians. Chicken liver is in high demand by the public because it is cheap. To analyze the freshness of chicken liver in the package easily and practically, so analytical tools were needed. The purpose of this study was to develop an edible freshness sensor based on anthocyanin purple sweet potato with bacterial cellulose membrane from nata de coco. The edible freshness sensor can be applied as a freshness sensor to determine the freshness level of chicken liver by various parameters. The color change of an edible freshness sensor was observed visually. The results showed that a change in the color of the freshness sensor, namely light blue when chicken liver was fresh, and dark blue when chicken liver was no longer fresh.
Implementasi Kegiatan “Fun Sensory Learning” Untuk Anak Usia 1-2 Tahun Di Panti Yayasan Mansyaul Ihsan
Authors: Julianti Anita Puspita , Salsabila Annida , Artanti Fadhilah , Chairunnisa Fima , Aulia Meirantie 
Published: September 2023

Kurangnya pemahaman orangtua terhadap perkembangan sensorimotor pada anak yang berdampak lambatnya stimulus pada perkembangan sensorimotor. Menstimulus sensori anak usia 1-2 tahun sangat penting. Apabila anak terstimulus sensorimotor dengan optimal dapat membantu membangun dan menguatkan koneksi saraf pada otak anak (perkembangan kognitif), memberikan informasi didunia sekitar anak dan membebaskan anak dalam bereksplorasi, seperti mengenali tekstur-tekstur, warna, nama hewan yang dapat membantu anak dalam pemahaman tentang dunia sekitar. Diperlukannya ide dalam metode pengabdian pada masyarakat dengan cara melakukan kegiatan sensori yang dilakukan selama 4 hari bertujuan untuk membantu orangtua di salah satu yayasan yang berada di pasawahan dengan menggunakan kegiatan kelas sensori, atas perizinan pihak yayasan mansyaul ihsan, serta orangtua dan anak-anak. Berbagai metode pengabdian yang dilakukan dengan kegiatan-kegiatan seperti bermain agar-agar, bermain beras, bermain biji selasih, dan bermain warna. Adanya kegiatan bernyanyi dan berbagi pengalaman sebagai kegiatan tambahan sehingga kegiatan ini terasa menyenangkan. Dari kegiatan kelas sensori yang kita lakukan tersebut bertujuan untuk mengasah dan menstimulus sensorimotor anak usia 1-2 tahun. Hasil yang didapatkan dari adanya kegiatan ini adalah orang tua mendapat informasi atau ilmu baru serta anak meningkatnya stimulus perkembangan sensori anak.
Implementasi MBKM Di Luar Program Studi Pendidikan Olahraga (S1) Universitas Bina Darma
Authors: Melianty Selvi , Endrawan I Bagus , Hardiyono Bayu , Kesumawati Selvi Atesya , Septaliza Dewi , Sukmawati Noviria , Muslimin Muslimin , Laili Reni 
Published: September 2023

Tujuan kegiatan ini untuk meningkatkan jumlah program studi yang menerapkan program MBKM, memfasilitasi program studi untuk mengembangkan kurikulum sesuai dengan kebijakan MBKM, menghasilkan pengalaman baik (good practices) di perguruan tinggi dalam menyusun dan mengimplementasikan kurikulum program MBKM yang memiliki capaian pembelajaran lulusan sesuai dengan KKNI dan SN-Dikti. Manfaat penyelenggaraan program bantuan program studi menerapkan kerja sama kurikulum MBKM diharapkan dapat dirasakan manfaatnya oleh mahasiswa, dosen, program studi, perguruan tinggi, serta mitra. Metode yang dilakukan dalam kegiatan ini adalah Focus Group Discusion (FGD) membahas mengenai “Penyusunan Prosedur Oprasional Baku Implementasi MBKM di Luar Program Studi Pendidikan Olahraga (S1) di Universitas Bina Darma”. Program Studi Pendidikan Olahraga melalui aplikasi Zoom Meeting. Hasil dari kegiatan ini diharapkan dapat memberi kemudahan kepada mahasiswa untuk belajar dimana saja dan kapan saja.
Study of the direct economic benefits of mangrove ecosystems in Moko Village, Lakudo District, Central Buton Regency, Southeast Sulawesi
Authors: Rosmawati  , Haris Abdul , Nurdiana A  , Piliana Wa Ode , Hamzah Muhaimin , Sidiq Azwar 
Published: September 2023

Mangroves are one of the coastal ecosystems with various ecosystem services include economic benefits. The purpose of this study is to determine the economic value of mangrove ecosystems that are directly utilized by the people of Moko Village, Lakudo District, Central Buton Regency, Southeast Sulawesi. This research was conducted during the period from August to September 2021. The sampling method used was the accidental sampling method, which is a non-probability sampling technique by determining the sample based on who was encountered at the time of data collection. The research sample was the people of Moko Village who live around the mangroves and directly use of the products from the mangrove forest. The types of data used were primary data and secondary data that are qualitative and quantitative. Primary data were obtained directly from the field through interviews with related parties, questionnaires, and direct observation. Secondary data were obtained from the Tourism Office of Central Buton Regency and through literature studies that related to research aims The results of this study showed that the benefits of the mangrove ecosystem in Moko Village consisted of fishing, crab, and shrimp fishing around and in the mangrove forest. The annual total benefit value of mangroves was IDR.507,704,732,- which consisted of fish benefits of IDR 149,064,333,- crab benefits of IDR .230,170,566,- and shrimp benefits of IDR.128,469,833,-.
Analisis kelayakan usaha ekspor ikan (studi kasus PT. Hui Mei Wei Aquatic Product Trading) di Kota Kendari, Sulawesi Tenggara
Authors: Usman Rahmad Nuzul , Budiyanto  , Mansyur Akhmad , Annaastasia Nurhuda , Risfandi  
Published: September 2023

Adanya permintaan ekspor dari beberapa negara asia menjadikan komoditi perikanan sebagai produk unggulan yang mampu memberikan laba untuk membantu perekonomian nasional. Sulawesi Tenggara memiliki Pelabuhan Perikanan Samudera (PPS) sebagai pusat industri perikanan terpadu dikawasan wilayah Indonesia bagian Timur yang mampu meningkatkan produksi perikanan serta merupakan jalur perdagangan antar pulau. Penelitian ini bertujuan untuk mengetahui kelayakan usaha ekspor ikan di PT. Hui Mei Wei Aquatic Product Trading di Kota Kendari Sulawesi Tenggara. Penelitian ini dilaksanakan pada bulan Juni Tahun 2022. Metode penelitian yang digunakan adalah studi kasus. Data penelitian yang dikumpulkan berupa total biaya (biaya tetap dan biaya variabel), jumlah produksi, harga jual ikan, dan penerimaan. Data dianalisis menggunakan rumus kelayakan usaha yaitu R/C Ratio. Hasil penelitian ini menunjukkan bahwa R/C Ratio sebesar 1.68. artinya setiap pengeluaran sebesar Rp1 oleh industri akan memperoleh penerimaan sebesar RP1,68. dengan demikian, usaha ekspor ikan yang dilakukan oleh PT. PT. Hui Mei Wei Aquatic Product Trading layak untuk dikembangkan.
The origin of eukaryotes and rise in complexity were synchronous with the rise in oxygen
Authors: Craig Jack M. , Kumar Sudhir , Hedges S. Blair 
Published: September 2023

The origin of eukaryotes was among the most important events in the history of life, spawning a new evolutionary lineage that led to all complex multicellular organisms. However, the timing of this event, crucial for understanding its environmental context, has been difficult to establish. The fossil and biomarker records are sparse and molecular clocks have thus far not reached a consensus, with dates spanning 2.1–0.91 billion years ago (Ga) for critical nodes. Notably, molecular time estimates for the last common ancestor of eukaryotes are typically hundreds of millions of years younger than the Great Oxidation Event (GOE, 2.43–2.22 Ga), leading researchers to question the presumptive link between eukaryotes and oxygen. We obtained a new time estimate for the origin of eukaryotes using genetic data of both archaeal and bacterial origin, the latter rarely used in past studies. We also avoided potential calibration biases that may have affected earlier studies. We obtained a conservative interval of 2.2–1.5 Ga, with an even narrower core interval of 2.0–1.8 Ga, for the origin of eukaryotes, a period closely aligned with the rise in oxygen. We further reconstructed the history of biological complexity across the tree of life using three universal measures: cell types, genes, and genome size. We found that the rise in complexity was temporally consistent with and followed a pattern similar to the rise in oxygen. This suggests a causal relationship stemming from the increased energy needs of complex life fulfilled by oxygen.
La-based perovskites for capacity enhancement of Li–O2 batteries
Authors: Hsu Bing-Ze , Lai Jun-Kai , Lee Yi-Hsuan 
Published: September 2023

Li–O2 batteries are a promising technology for the upcoming energy storage requirements because of their high theoretical specific energy density of 11,680 Wh kg−1. Currently, the actual capacity of Li–O2 batteries is much lower than this theoretical value. In many studies, perovskites have been applied as catalysts to improve the air electrode reactions in Li–O2 batteries. The effects of structure and doping on the catalytic activity of perovskites are still unclear. La1-xSrxCoO3-δ (x = 0.1, 0.3, and 0.5) and La0.9Sr0.1YbO3-δ mixed with carbon black (Vulcan XC500 or Super P) were used as air electrode catalysts. Electrochemical characterizations were conducted using a Swagelok-type cell. The charge–discharge capacity and cyclic voltammetry (CV) performance were investigated in this study. The La1-xSrxCoO3-δ (x = 0.1, 0.3, and 0.5) is a suitable cathode catalyst for Li–O2 batteries. In this study, the La0.5Sr0.5CoO3-δ/Super P cathode demonstrated the highest discharge capacity (6,032 mAh g−1). This excellent performance was attributed to the large reaction area and enhanced Li2CO3 generation.
Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4
Authors: Zhang Wei , Xu Li , Zhang Xiaoyan , Xu Jianqing , Jin Jun-O 
Published: September 2023

BackgroundMacrophages are key effector cells of innate immunity and play a critical role in the immune balance of disease pathogenesis, especially in the tumor microenvironment. In previous studies, we showed that FimH, an Escherichia coli adhesion portion, promoted dendritic cell activation. However, the effect of FimH in macrophage polarization has yet to be fully examined. In this study, we investigated the potential effect of FimH on macrophages, as well as the polarization from M2 to M1 macrophages, contributing to the overall antitumor effectMethodsMouse bone marrow derived macrophages and peritoneal macrophages were generated to test the effect of FimH in vitro. The expression of costimulatory molecules and production of cytokines were analyzed. The effect of FimH in the tumor-associated macrophages was examine in the B16F10-tumor bearing C57BL/6.ResultsFimH was found to promote M1 macrophage activation. In addition, FimH polarized M2 macrophages, which were induced by interleukin (IL)-4 and IL-13 into M1 macrophages were dependent on toll-like receptor 4 and myeloid differentiation factor 2. Moreover, FimH reprogramed the tumor-associated macrophage (TAM) into M1 macrophages in B16 melanoma tumor-bearing mice and promoted an inflammatory reaction in the tumor microenvironment (TME). Furthermore, FimH promoted M1 macrophage activation, as well as the reversion of M2 macrophages into M1 macrophages in humans. Finally, FimH treatment was found to enhance the anti-cancer immunity of anti-PD-L1 antibody by the induction of M1 polarization from TAM.ConclusionThis study demonstrated the potential effect of FimH on the activation of macrophages, responsible for the repolarization of M2 macrophages into the M1 phenotype via the TLR4 signaling pathway. Moreover, FimH could also reprogram TAM polarization to the M1 status in the TME, as well as enhance the anti-tumor activity of immune checkpoint blockade.
Bone wax reduces blood loss after total hip arthroplasty: a prospective, randomized controlled study
Authors: Li Hao , Huang Chao , Ding Zi-Chuan , Liu Zun-Han , Zhao En-Ze , Zhou Zong-Ke 
Published: September 2023

BackgroundPrevious studies have demonstrated the efficacy of bone wax in reducing blood loss in various orthopedic surgeries. However, the effect of bone wax on total hip arthroplasty (THA) remains unclear. The objective of this study was to assess the efficacy of bone wax in THA.MethodsWe enrolled 104 patients in this randomized controlled trial. These patients were randomized (1:1) to either the bone wax or control group. The primary outcome was total blood loss after THA. The secondary outcomes included serum hemoglobin (Hb) level, change in Hb level, lower limb diameters on the first and third postoperative day (POD), range of motion at discharge, length of postoperative hospital stay, and adverse events.ResultsPatients in the bone wax group had significantly lower total blood loss on PODs 1 and 3 (p &lt; 0.05). Moreover, patients in the bone wax group performed better in terms of postoperative serum Hb level, change in Hb level on PODs 1 and 3, and length of postoperative hospital stay (all p &lt; 0.05). Patients in the bone wax group did not experience any bone wax-related adverse events.ConclusionBone wax administration in THA significantly reduced perioperative blood loss. Therefore, bone wax is promising for optimizing blood-conserving management protocols in THA.Clinical trial registration[https://clinicaltrials.gov/], identifier [ChiCTR2100043868].
Does healthcare consumerism serve as a barrier or facilitator to the implementation of value-based primary care? Strategies to promote synergy and success
Authors: Rangachari Pavani 
Published: September 2023

IntroductionValue in health care is described as the measured improvement in a patient’s health outcomes for the cost of achieving that improvement. In the United States, value-based care has been heralded by providers, payers, and policymakers alike, as a path to addressing the challenges facing the healthcare system and achieving the aspirational goals of the Quadruple Aim of healthcare. Primary care is often viewed as the foundational cornerstone for implementing value-based care. However, primary care is also considered as ground-zero for the rise in healthcare consumerism.MethodsIn essence, consumerism refers to increasing expectations from patients (consumers) to be more active participants in decisions related to their healthcare. While much of the literature has portrayed the rise in consumerism as a barrier to the implementation of value-based primary care, some have argued that it may have potential to synergize with and facilitate the implementation of value-based primary care. This paper applies an enhanced stepwise implementation framework for value-based (equitable) care, to examine the potential for conflict and synergy between consumerism and value-based care in the emerging retail model of primary care. The application is based on the potential actions of four key stakeholder groups: (1) retail healthcare entities, (2) primary-care providers, (3) consumers (patients), and (4) healthcare payers.ResultsThe analysis helps to articulate the responsibilities of each stakeholder group in ensuring synergy between consumerism and value-based primary care. In addition, it helps to identify three drivers of synergy between consumerism and value-based care: (1) trust in the patient-provider relationship, (2) connected consumer-centric technology solutions, and (3) value-based consumer-centric payment models.DiscussionOverall, the application helps to articulate a comprehensive framework for implementing value-based care that incorporates both the principles of consumerism and active consideration for health equity.
Semantic processing during continuous speech production: an analysis from eye movements and EEG
Authors: Huang Jinfeng , Zhang Gaoyan , Dang Jianwu , Chen Yu , Miyamoto Shoko 
Published: September 2023

IntroductionSpeech production involves neurological planning and articulatory execution. How speakers prepare for articulation is a significant aspect of speech production research. Previous studies have focused on isolated words or short phrases to explore speech planning mechanisms linked to articulatory behaviors, including investigating the eye-voice span (EVS) during text reading. However, these experimental paradigms lack real-world speech process replication. Additionally, our understanding of the neurological dimension of speech planning remains limited.MethodsThis study examines speech planning mechanisms during continuous speech production by analyzing behavioral (eye movement and speech) and neurophysiological (EEG) data within a continuous speech production task. The study specifically investigates the influence of semantic consistency on speech planning and the occurrence of “look ahead” behavior.ResultsThe outcomes reveal the pivotal role of semantic coherence in facilitating fluent speech production. Speakers access lexical representations and phonological information before initiating speech, emphasizing the significance of semantic processing in speech planning. Behaviorally, the EVS decreases progressively during continuous reading of regular sentences, with a slight increase for non-regular sentences. Moreover, eye movement pattern analysis identifies two distinct speech production modes, highlighting the importance of semantic comprehension and prediction in higher-level lexical processing. Neurologically, the dual pathway model of speech production is supported, indicating a dorsal information flow and frontal lobe involvement. The brain network linked to semantic understanding exhibits a negative correlation with semantic coherence, with significant activation during semantic incoherence and suppression in regular sentences.DiscussionThe study’s findings enhance comprehension of speech planning mechanisms and offer insights into the role of semantic coherence in continuous speech production. Furthermore, the research methodology establishes a valuable framework for future investigations in this domain.
Cardiovascular effects of auricular stimulation -a systematic review and meta-analysis of randomized controlled clinical trials
Authors: Hua Kevin , Cummings Mike , Bernatik Miriam , Brinkhaus Benno , Usichenko Taras , Dietzel Joanna 
Published: September 2023

BackgroundThe number of randomized controlled trials using auricular stimulation (AS) such as transauricular vagus nerve stimulation, or other auricular electrostimulation or auricular acupuncture or acupressure, in experimental and clinical settings, has increased markedly over the last three decades. This systematic review focusses on cardiovascular effects of auricular stimulation.Methods and analysisThe following databases were searched: MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ISI Web of Science, and Scopus Database. RCTs were reviewed that had been published in English and European languages. Data collection and analysis was conducted by two reviewers independently. Quality and risk assessment of included studies was performed and the meta-analysis of the effect of the most frequently assessed biomarkers.ResultsAltogether, 78 trials were included. 38 studies assessed heart rate (HR), 19 studies analyzed heart rate variability (HRV), 31 studies analyzed blood pressure (BP) and 7 studies were identified that measured oxygen saturation (O2), 2 studies on baroreflex sensitivity and 2 studies on skin conductance were evaluated in this review. 26 studies contained continuous data and were eligible for meta-analysis, 50 trials reported non continuous data and were evaluated descriptively. The overall quality of the studies was moderate to low. AS leads to a significant reduction of HR, the changes though were not considered an adverse reaction. Furthermore, when looking at HRV, AS was able to reduce the LF/HF ratio significantly compared to control procedures. No other cardiovascular parameters (blood pressure, oxygen saturation, baroreflex sensitivity) were changed significantly. AS produced only minor side effects in all trials.ConclusionAS can lead to clinically safe reduction of HR and changes in the LF/HF ratio of the HRV, which is presumably via an increase in vagal activity. More research is needed to clarify whether AS can be used to modulate tachycardia or indications with autonomic imbalance.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=231885 PROSPERO, ID CRD42021231885.
Multilevel analysis of trends and predictors of concurrent wasting and stunting among children 6–59 months in Ethiopia from 2000 to 2019
Authors: Roba Aklilu Abrham , Başdaş Öznur 
Published: September 2023

IntroductionEmerging evidence indicates that children can be concurrently wasted and stunted (WaSt), increasing their mortality risk. However, more is needed to know about WaSt in Ethiopia. Therefore, this study aimed to determine the trends and predictors of WaSt using Ethiopian Demographic and Health Survey datasets from 2000 and 2019.MethodsThe study included a total weighted sample of 34,930 children aged 6–59 months. Descriptive and weighted multilevel mixed-effects (fixed and random effects) logistic regression analyses were carried out. The Intraclass Correlation Coefficient (ICC) and the Median Odds Ratio (MOR) were calculated.ResultsThe prevalence of WaSt was 1,682 (4.82%) with a significantly decreasing trend, yielding a percent change of −57.51% (−69.37% to −23.52%) from 2000 to 2019. In the adjusted model, the odds of WaSt increased in boys, children with a shorter preceding birth interval, small birth size, delayed initiation of complementary foods, diarrhea, fever, and anemia, mother’s lack of formal education, and being a farmer, and poor/middle wealth index, and lack of mass media exposure. WaSt was inversely related to the child’s age. Adjusted ICC and MOR were 31.16% and 3.20%, respectively.Conclusion and recommendationsThe study highlights the importance of considering individual and community-level factors to address WaSt, such as timely initiation of complementary foods, improving access to health services, quality diet, and prevention of communicable diseases. Furthermore, programs that have positive impacts on formal education and employment opportunities for girls, as well as that increase access to mass media, are required.