bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warming experiment indicates that increasing global temperatures may not affect windows of opportunity for salt marsh seedlings
Authors: Ostertag Eva Julia Marie , Jensen Kai , Unger Viktoria , Nolte Stefanie 
Published: August 2023

AbstractWith increasing global temperatures, it remains unclear, how seedling emergence and survival will be affected in highly dynamic ecosystems like salt marshes. Our study combines passive and active warming treatments with the natural inundation dynamics of salt marshes. We studied the effects of active soil and passive air warming (ambient temperature, + 1.5°C and + 3.0°C) on seedling numbers of different species in three salt marsh zones (pioneer zone, low marsh, and high marsh) and on seedling survival (lifespan), seedling diversity and species richness in two salt marsh zones (low marsh and high marsh) in situ. We found a significant influence of warming on Shannon diversity at two dates, but we found no significant effects of warming on seedling number and survival. However, we found trends, which differed between zones. In the pioneer zone, seedling numbers were slightly higher in the warming treatments than in the ambient treatment from April to June. Whereas, in the high marsh, seedling numbers decreased more in the warming treatments during the same period. The median lifespan was slightly reduced under warming treatments. We conclude warming might have increased drought stress for seedlings in the high marsh, which led to the trend of lower seedling numbers and shorter survival times. Seedling number decreased with elevation, which could be attributed to both species‐specific strategies and differences in available space. Median survival differed significantly between species, which we assume is due to differing life‐history traits like seed size and if the species are annual or perennial.
Culture clash or collaboration? Unraveling the role of hierarchical organizational culture in International Financial Reporting Standards adoption
Authors: Bansal Manish 
Published: August 2023

AbstractThis research study investigates the influence of organizational culture on the quality of earnings when adopting International Financial Reporting Standards (IFRS). The results reveal a positive association between hierarchical organizational culture and earnings quality, indicating that organizations with strong hierarchical cultures tend to generate high‐quality financial reports during the implementation of IFRS. This finding aligns with the principles of contingency theory, which suggests that hierarchical cultures are particularly effective in ensuring accurate and reliable financial reporting, especially in situations characterized by high uncertainty or complexity. Based on these findings, the study recommends the cultivation of a favorable organizational culture to maximize the benefits of IFRS in terms of higher earnings quality under the new accounting standards. By nurturing a hierarchical culture that prioritizes accuracy, accountability, and compliance, organizations can enhance their ability to produce reliable financial reports and effectively meet the requirements of IFRS. Overall, this research contributes valuable insights into the relationship between organizational culture, IFRS adoption, and earnings quality. The practical implications derived from these findings emphasize the significance of fostering a supportive organizational culture to harness the positive impact of IFRS on earnings quality.
A case report of a novel HIST1H1E mutation and a review of the bibliography to evaluate the genotype–phenotype correlations
Authors: Zhao Wenjing , Zhang Yinhong , Lv Tao , He Jing , Zhu Baosheng 
Published: August 2023

AbstractBackgroundHIST1H1E is a member of the H1 gene family. Excess de novo likely gene‐disruptive variants involving the C‐terminal tail of HIST1H1E have been reported in neurodevelopmental disorders. Although clinical phenotypes in some patients have been described in single studies, few studies have reviewed the genotype and phenotype relationships using a relatively large cohort of patients with HIST1H1E variants.MethodsWhole‐exome sequencing (WES) was performed on the proband. The variant was validated using Sanger sequencing in both proband and parents. Published HIST1H1E variants in neuropsychiatric disorders were reviewed.ResultsHerein, we reported a new de novo frameshift mutation in HIST1H1E (NM_005321.2, c.416_419dupAGAA, p.Ala141GlufsTer56) in an individual with Rahman syndrome. To explore the genotype–phenotype correlations for HIST1H1E variants in neurodevelopmental disorders, we comprehensively curated and summarized 23 variants and the clinical features from 52 patients. Our findings revealed that likely gene‐disrupting variants in HIST1H1E contribute to a wide range of neurodevelopmental phenotypes. We observed the common phenotypes including craniofacial features, ID, hypotonia, and autism/behavior problem in patients with HIST1H1E variants. While the different genotypes corresponding to different phenotypes or the same phenotype were also observed.ConclusionThese data provide scientific evidence for the genetic diagnosis and precision clinical management.
Hyperhomocysteinemia in patients with riboflavin‐responsive multiple acyl‐CoA dehydrogenase deficiency
Authors: Zhang Huiqiu , Zhao Rongjuan , Ma Jing , Zhang Jingfei , Wang Juan , Chang Xueli , Guo Junhong , Zhang Wei 
Published: August 2023

AbstractIntroduction/AimsRiboflavin‐responsive multiple acyl‐CoA dehydrogenase deficiency (RR‐MADD) is an autosomal recessive disease chiefly caused by variants of ETFDH affecting fatty acid metabolism. In our cohort, hyperhomocysteinemia (HHcy) was common. In this study we aimed to identify the association between RR‐MADD and HHcy.MethodsWe performed a retrospective review of 13 patients with RR‐MADD. Thirty‐three healthy controls were recruited, and logistic regression was used to investigate the association between RR‐MADD and HHcy. Muscle tissues from six patients and six controls without myopathies were collected to measure the levels of flavin adenine dinucleotide (FAD), an active form of riboflavin. Whole‐exome sequencing was performed to identify the disease‐associated variants.ResultsThe RR‐MADD patients had a higher prevalence of HHcy (9 of 12) than controls (6 of 33, P < .001). In the multivariate analysis, RR‐MADD was positively related to HHcy (P = .014). Muscular FAD levels were decreased in RR‐MADD patients (P = .006). Thirteen variants (8 reported and 5 novel) were identified in ETFDH. Of these, c.250G > A was the most common pathogenic variant with an allelic frequency of 4 of 20.DiscussionHHcy was associated with RR‐MADD and may aid in the diagnosis of the disease. Our findings expand the mutational spectrum of RR‐MADD.
A hypoplastic model for hydrate‐bearing sand considering hydrate saturation and grain breakage
Authors: Qian Haoyong , Wu Wei , Xu Chengshun , Du Xiuli 
Published: August 2023

AbstractWe present a hypoplastic model to capture the mechanical responses of hydrate‐bearing sands by incorporating hydrate saturation and grain breakage. In our model, a new degradation scalar is introduced to account for the effects of hydrate bonding evolution on strength. We also adopt the variable critical state line to assess the effects of hydrate saturation and relative breakage ratio at high confining pressure. This model is validated by modeling a series of laboratory tests.
‘Do we need doulas…?’ – Perspectives of maternity care managers on the role of doulas in Poland
Authors: Wójcik‐Brylska Katarzyna , Pawlicka Paulina , Tataj‐Puzyna Urszula , Szlendak Beata , Baranowska Barbara 
Published: August 2023

AbstractAimThe purpose of this study was to analyse perinatal care managers' perspectives on the role of doulas in Poland and to consider how managers' perspectives might affect the opportunities for doulas to practice in individual hospitals.DesignThis is a qualitative descriptive study.MethodThe total of 17 hospitals was selected for the study. Semi‐structured interviews were conducted with 11 manager staff members.ResultsThree groups of facilities were identified: ‘0’ (n = 6) – refused to give interviews, ‘A’ (n = 8) – marginal experience in working with doulas, and ‘B’ (n = 3) – regular experience in working with doulas. The hospitals from Group A showed indifference towards working with doulas. Group B declared a positive attitude towards such cooperation. Attitudes towards doulas vary among executives and are related to the frequency of doula‐assisted births. Our results indicate factors that may influence the attitude of medical staff towards doulas and which may contribute to improve future initiatives meant to facilitate collaboration between midwives and doulas.Patient or Public ContributionThis study explored the lived experiences of perinatal care managers.
Developing a talent management framework for domestically and internationally trained nurses and midwives in healthcare organizations: A mixed‐methods research protocol
Authors: Berkery Elaine , Ryan Nuala , O'Malley Bernadette , Purtill Helen , O'Donnell Claire 
Published: August 2023

AbstractAimThe aim of this study is to gather evidence on talent management practices for nurses and midwives in an Irish hospital group, to identify any shortcomings in the current practices and to develop an evidence‐based talent management framework for the hospital group.DesignThis paper details a protocol for a mixed methods research study that will be used to (1) identify, critically evaluate and summarize academic scholarship on talent management strategies for both domestically and internationally trained nurses and midwives, leading to the development of a model of talent management for this study, (2) gather evidence from both domestic and internationally trained nurses and midwives, via questionnaires and focus groups within the hospital group on current talent management practices and (3) use the model previously developed to organize our findings and develop a talent management framework for the hospital group.MethodsThe study will adapt a mixed methods approach. Quantitative data will be analysed using SPSS, and qualitative data will be analysed using NVivo.ResultsOur findings will support a stakeholder approach to the development of talent management practices for both domestic and internationally trained nurses and midwives in healthcare organizations. Doing so should improve the pipeline of suitably qualified nurses and midwives for future roles, by assisting nurses and midwives to identify career paths and future educational opportunities. From an organizational perspective, this research will allow healthcare organizations to adapt their current workforce planning strategies, tailoring them to the needs of the current workforce, which should reduce turnover, ensuring a highly skilled workforce, with the appropriate numbers to provide the care required within that healthcare setting.No Patient of Public ContributionContributions will be sought from nursing and midwifery staff and management within the hospital group.
Presurgical microstructural coherence predicts cognitive change for bariatric surgery patients
Authors: Chen Alexa K. , Gullett Joseph M. , Williamson John B. , Cohen Ronald A. 
Published: August 2023

AbstractObjectiveThis observational study examined the relationship between presurgical white matter microstructural coherence and cognitive change after weight loss. It was hypothesized that higher baseline fractional anisotropy (FA) would predict greater baseline and change cognition.MethodsA sample of 24 adults (BMI ≥ 35 kg/m2) underwent neuropsychological assessment at baseline and 12 weeks after bariatric surgery. A magnetic resonance imaging brain scan was administered at baseline and processed through Tract‐Based Spatial Statistics to compute FA in white matter tracts of interest. Composite scores for attention, learning, processing speed, executive function, verbal fluency, working memory, and overall cognition were calculated.ResultsAs expected, FA in some tracts of interest was significantly (p < 0.05) positively associated with change in cognition. Inverse relationships were observed between baseline FA and presurgical cognition, which may be explained by increased medial and radial diffusivity and preserved axonal diffusivity. Cognition generally improved after surgery; however, relative but clinically nonsignificant deterioration was observed on learning measures. Poorer baseline cognitive performance was associated with greater postsurgical cognitive improvement.ConclusionsPresurgical microstructural coherence is associated with magnitude of cognitive change after weight loss. An observed reduction in learning suggests that bariatric surgery may lead to negative outcomes in some cognitive domains, at least temporarily.
Perioperative management of maxillary cyst and genetic analysis in a patient with glycogen storage disease type 1a: A rare case report
Authors: Obayashi Fumitaka , Tani Ryouji , Hamada Atsuko , Ito Nanako , Koizumi Koichi , Yanamoto Souichi 
Published: August 2023

AbstractBackgroundGlycogen storage disease type 1a (GSD1a) is an autosomal recessive genetic disease with symptoms such as hypoglycemia, lactic acidosis, and bleeding tendency.Case PresentationA 15‐year‐old male patient underwent cystectomy under general anesthesia. He had GSD1a. Despite perioperative blood glucose control, lactic acidosis worsened. No abnormal bleeding or infections were observed. A homozygous mutation of c.648G>T was detected by genetic testing for glucose‐6‐phosphatase (G6PC).ConclusionPerioperative complications specific to this disease should be managed.
Navigating collaborative governance in Florida: An analysis of local governments resilience amidst the COVID‐19 pandemic
Authors: Alibašić Haris , Casula Mattia 
Published: August 2023

This study investigates the effectiveness of collaborative governance in the context of state and local government responses to the COVID‐19 pandemic in Florida. Our analysis uncovers how local authorities have successfully adapted to implement policies to increase resilience and address the crisis, despite facing challenges, constraints, and limitations. Our findings underscore the significance of considering unique local characteristics when addressing pandemics and shed light on the potential influences of state‐level actors on Home Rule. Notably, research examining the interplay between state decisions and Home Rule during a pandemic is scarce. We utilize Florida as a case study to examine local government responses to COVID‐19, employing a qualitative analysis of data from webinars hosted by the Florida League of Cities and media reports on local government actions. To substantiate our findings and encourage further research, we apply the collaborative governance framework in the context of local government administrative responsibilities.
C/EBPβ isoform‐specific regulation of podocyte pyroptosis in lupus nephritis‐induced renal injury
Authors: Zou Huimei , Chen Min , Wang Xiuhong , Yu Jie , Li Xiaoying , Xie Ying , Liu Jun , Liu Miao , Xu Lifen , Zhang Qiong , Tian Xiaoxue , Zhang Fan , Guo Bing 
Published: August 2023

AbstractAs an essential factor in the prognosis of systemic lupus erythematosus (SLE), lupus nephritis (LN) can accelerate the rate at which patients with SLE can transition to chronic kidney disease or even end‐stage renal disease. Podocytes now appear to be a possible direct target in LN in addition to being prone to collateral damage from glomerular capillary lesions induces by immune complexes and inflammatory processes. The NLRP3 inflammasome is regulated by CCAAT/enhancer‐binding protein β (C/EBPβ), which is involved in the pathogenesis of SLE. However, the role and mechanism of C/EBPβ in LN remain unclear. In this investigation, glomerular podocytes treated with LN serum and MRL/lpr mice were employed as in vivo and in vitro models of LN, respectively. In vivo, the expression of C/EBPβ isoforms was detected in kidney specimens of humans and mice with LN. Then we assessed the effect of C/EBPβ inhibition on renal structure and function by injecting RNAi adeno‐associated virus of C/EBPβ shRNA into MRL/lpr mice. In vitro, glomerular podocytes were treated with LN serum and C/EBPβ siRNA to explore the role of C/EBPβ in the activation of the AIM2 inflammasome and podocyte injury. C/EBPβ‐LAP and C/EBPβ‐LIP were significantly overexpressed in kidney tissue samples from LN patients and mice, and C/EBPβ inhibition significantly alleviated renal function damage and ameliorated renal structural deficiencies. Inflammatory pathways downstream from the AIM2 inflammasome could be suppressed by C/EBPβ knockdown. Furthermore, the upregulation of C/EBPβ‐LAP could activate the AIM2 inflammasome and podocyte pyroptosis by binding to the promoters of AIM2 and CASPASE1 to enhance their expression, and the knockdown of AIM2 or (and) caspase‐1 reversed the effects of C/EBPβ‐LAP overexpression. Interestingly, C/EBPβ‐LIP overexpression could transcriptionally inhibit IRAG and promote Ca2+ release‐mediated activation of the AIM2 inflammasome. This finding suggests that C/EBPβ is not only involved in the regulation of the expression of key proteins of the AIM2 inflammasome but also affects the polymerization of key proteins of the AIM2 inflammasome through the regulation of Ca2+ release. In conclusion, this study provides a new idea for studying the regulatory mechanism of C/EBPβ and provides a theoretical basis for the early diagnosis and treatment of LN in the future. © 2023 The Pathological Society of Great Britain and Ireland.
Unveiling new frontiers: Bast fiber‐reinforced polymer composites and their mechanical properties
Authors: Syduzzaman Md. , Hassan Abir , Anik Habibur Rahman , Tania Imana Shahrin , Ferdous Tabassum , Fahmi Fahmida Faiza 
Published: August 2023

AbstractBast fibers such as flax, hemp, and jute‐reinforced polymer composites due to their exceptional properties are gaining significant demand as a sustainable and cost‐effective alternative to conventional synthetic fiber‐reinforced composites. This comprehensive study aims to shed light on the potential of bast fiber reinforced composites (BFRCs) as innovative materials for various industrial applications. The manuscript presents a comprehensive discussion on bast fibers, polymer matrices, and the fabrication techniques employed to produce BFPCs, highlighting the effects of different modification techniques on the resulting mechanical properties. Industrial and structural applications of BFPCs are explored, with a specific focus on their use in the automotive and aerospace industries, construction materials, and sporting goods. Finally, the manuscript concludes with a discussion of the challenges and future prospects of BFPCs. This manuscript can serve as a valuable resource for researchers, engineers, and professionals interested in the emerging field of bast fiber‐reinforced polymer composites. It opens new frontiers in material design and highlights the enormous potential of BFPCs to revolutionize industrial applications through their exceptional mechanical properties.Highlights
Materials and processing of fiber‐reinforced polymer nanocomposites.
Exploration of various fiber and matrix modification techniques.
Recent advances in the mechanical properties of bast fiber‐reinforced composites.
Ashby charts to illustrate the comparative analysis.
In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect
Authors: Khodabakhshi Vahid , Soleimanimehr Hamid , Etemadi Haghighi Shahram , Imam Ali 
Published: August 2023

AbstractSegmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this article, 3D printing was used to fabricate the polycaprolactone (PCL)/NaCl‐based cylindrical structures. The effects of the structure's thickness (L) and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD). Results showed that increasing the NaCl concentration up to 10% wt significantly improved the degradability, swelling, and hydrophilicity of the structures. It was also indicated that the maximum stiffness of the guide structures under vertical loading was almost five times larger than the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. Results indicated that the mechanical properties of the structures were more dependent on the structure thickness so the thicker structures with an 800 μm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the nontoxic effect of the PCL structures on the MC3T3 osteoblast cell line. Based on the results, the PCL‐based structures were a suitable candidate to act as a guide for segmental bone tissue engineering.Highlights
A 3D‐printed conduit was manufactured to guide bone reconstruction
Response surface methodology (RSM) using central composite design (CCD) was employed
NaCl concentration and the diameter of strands were the main parameters
This 3D‐printed guiding approach is useful for segmental bone tissue engineering
The effect of tranexamic acid on perioperative blood loss in transurethral resection of the prostate: A double‐blind, randomized controlled trial
Authors: Vanderbruggen Wies , Brits Tim , Tilborghs Sam , Derickx Katleen , De Wachter Stefan 
Published: August 2023

AbstractBackgroundBleeding and bleeding‐related complications remain common after bipolar transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. This may possibly lead to prolonged postoperative irrigation, catheterization, and hospital stay. The objective of this trial was to evaluate the effect of high‐dose tranexamic acid (TXA) on perioperative blood loss in patients treated with bipolar TURP for prostate sizes between 30 and 80 g.MethodsWe conducted a single‐center, prospective, double‐blind, randomized controlled trial. Eighty patients were screened for inclusion between March 2020 and January 2023. After exclusion, 65 patients were randomized in two comparable groups. The TXA group (31 patients) received a TXA intravenous loading dose of 10 mg/kg over 30 min before induction, followed by a maintenance dose of 5 mg/kg/h over 12 h. The placebo group (34 patients) received an equal dose of saline infusion. We measured age, weight, preoperative prostate size, anticoagulant use, 5‐alpha reductase inhibitor use, preoperative urinary tract infection, American Society of Anesthesiologists score, difference in pre‐ and 24 h postoperative hemoglobin and hematocrit levels, operative time, resected adenoma weight, duration of postoperative irrigation, total amount of postoperative irrigation fluid, indwelling catheter time, duration of hospital stay, blood transfusion rate, and 4‐week complication rate.ResultsBaseline characteristics in both groups were comparable. Postoperative hemoglobin decrease in TXA versus placebo group was 1 versus 1.6 mg/dL, respectively (p = 0.04). In addition, the amount of postoperative irrigation fluid (10.7 vs. 18.5 L), irrigation time (24.3 vs. 37.9 h), catheterization time (40.8 vs. 53.7 h), and hospital stay (46.9 vs. 59.2 h) were statistically significant in favor of TXA use. No blood transfusions were carried out. Four‐week complication rate was comparable between the two groups.ConclusionsPerioperative high‐dose TXA seems beneficial in reducing hemoglobin loss, postoperative irrigation, catheterization time, and hospital stay in bipolar TURP for prostate sizes between 30 and 80 g, without increased risk of TXA‐related thromboembolic events.