bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late pandemic COVID-19 positivity at the time of thrombectomy is associated with poor outcomes and tandem carotid pathology
Authors: Thompson Lewis John Rubin , Houk Clifton , Ellens Nathaniel R. , Kohli Gurkirat Singh , Schartz Derrek , Proper Diana , Bhalla Tarun , Bender Matthew T. , Mattingly Thomas K. 
Published: February 2025

ObjectivesCOVID-19 is an independent risk factor for ischemic stroke. Studies from early in the pandemic show increased rates of unfavorable recanalization, poor outcomes, and mortality in patients who were COVID-19 positive at the time of mechanical thrombectomy. However, there are currently no studies examining these parameters during the later pandemic when circulating variants were less virulent.Materials and methodsWe performed a retrospective review of mechanical thrombectomies from 12/2020 to 3/2023. Patients who were COVID-19 positive at the time of thrombectomy were included. Demographic, procedural, and 90-day functional outcomes were evaluated.ResultsOf 306 patients undergoing mechanical thrombectomy for acute ischemic stroke between 12/2020 and 3/2023, 18 were COVID-19 positive. Compared with the COVID-19 negative cohort, there were lower rates of favorable recanalization (73% vs. 92%, p = 0.03) and good functional outcomes (26% vs. 49%, p = 0.06), but greater tandem carotid pathology (42% vs. 12%, p &lt; 0.01), and a higher mortality rate (53% vs. 26%, p = 0.02). However, COVID-19 positive status did not predict outcomes in multivariable analysis when controlled for age, NIHSS, IV tPA, recanalization status, and tandem carotid pathology.ConclusionLate in the pandemic, outcomes remained comparable to those observed in the early pandemic for patients positive for COVID-19 at the time of mechanical thrombectomy. This case series also demonstrates increased tandem carotid pathology in the COVID-19 cohort. While COVID-19 may not influence outcome to the degree that age and NIHSS do, the excess mortality continues to suggest a negative effect despite lower virulence.
Clinical study of the relationship between hepatitis B core antibody and mechanical ventilation in patients with Guillain-Barré syndrome
Authors: Zhang Wei , Yao Qian , Wang Yuqiao , Yin Junxiong , Yang Xinxin 
Published: February 2025

IntroductionThe aim of this study was to investigate the association between hepatitis B core antibody (HBcAb) positivity and the need of mechanical ventilation (MV) in patients with Guillain-Barré syndrome (GBS).MethodsWe retrospectively analyzed the clinical data of 159 patients who were diagnosed with GBS between December 2014 and April 2023 in the Affiliated Hospital of Xuzhou Medical University. Patients were categorized into two groups according to the need for MV. Variables that were significantly different between the two groups in univariate analysis were analyzed through multivariate logistic regression models.ResultsThe final study population included 159 patients, 28 (17.6%) of whom need MV. In univariate analysis, Medical Research council sum score (MRC) on admission (p &lt; 0.001), bulbar paralysis (p &lt; 0.001), autonomic dysfunction (p &lt; 0.001), HBcAb (p = 0.009), neutrophil/lymphocyte ratio (NLR) (p &lt; 0.001), and Serum albumin (p = 0.016) were associated with MV. Multivariate logistic regression analysis showed lower MRC on admission (OR = 0.946, 95%CI: 0.908–0.985, p = 0.008), bulbar paralysis (OR = 3.726, 95%CI: 1.118–12.421, p = 0.032), autonomic dysfunction (OR = 3.804, 95%CI: 1.058–13.679, p = 0.041), HBcAb positivity (OR = 6.154, 95%CI: 1.253–30.229, p = 0.025), and higher NLR (OR = 1.214, 95%CI: 1.039–1.417, p = 0.014) were the risk factors for the need of MV in patients with GBS.ConclusionHBcAb positivity increased the risk of MV in patients with GBS. Lower MRC on admission, bulbar paralysis, autonomic dysfunction, and higher NLR were the risk factors for the need for MV.
Case report: Exploring cortico-muscular coherence during Mirror visual feedback for deafferentation pain: a proof-of-concept study
Authors: Segawa Shiori , Osumi Michihiro 
Published: February 2025

BackgroundMirror visual feedback (MVF) has shown promise as a treatment for deafferentation pain following brachial plexus injury, yet the underlying mechanisms remain unclear. This study aimed to assess MVF’s effect on two patients with deafferentation pain by analyzing cortico-muscular coherence (CMC), a measure of functional connectivity between the brain and muscles.MethodsTwo patients with brachial plexus injuries performed wrist movements with and without a mirror, accompanied by electromyography (EMG) and electroencephalography (EEG). CMC was calculated during each condition to determine changes in the sensorimotor network.ResultsIn Patient 1, CMC increased in the beta band in the extensor carpi radialis and surrounding parietal regions during the mirror condition. In Patient 2, beta-band CMC decreased in the compensatory muscle (biceps brachii) but increased in the primary muscle (flexor carpi ulnaris) when the mirror was used. These findings suggest MVF promotes sensorimotor integration, reducing pain intensity.ConclusionMirror visual feedback (MVF) effectively enhances CMC in the contralateral sensorimotor cortex in the beta frequency band, accompanied by pain relief in the affected limb. This suggests that CMC analysis could refine deafferentation pain rehabilitation using MVF, providing a better understanding of its neural mechanisms and optimizing therapeutic outcomes. Our study underscores the potential of CMC as a valuable biomarker for monitoring and tailoring MVF interventions.
Disconnection between sugars reduction and calorie reduction in baked goods and breakfast cereals with sugars-related nutrient content claims in the Canadian marketplace
Authors: Wang Ye Flora , Marsden Sandra , DiAngelo Chiara , Clarke Abigail , Chung Anita , Yu Jessica , Fan Zhongqi , Cooper Julian , Kitts David 
Published: February 2025

IntroductionNutrition claims aim to highlight key attributes in foods and assist consumers to make informed dietary choices. Consumers generally perceive products with claims related to lower sugars content as being healthier. Food manufacturers also use these claims to highlight reformulation action in response to consumer demands and government policies.MethodsA cross-sectional analysis of baked goods and breakfast cereals in the Canadian marketplace was conducted, focusing on the use of sugars-related nutrient content claims (i.e., “no added sugars,” “lower/reduced in sugars,” “sugar-free”) and changes in nutrients and energy content in reformulation strategies. Baked goods and breakfast cereals with sugars-related claims in Canada as of December 2022 were obtained from the Mintel Global New Products Database. Current product availability was verified using websites from manufacturers and major food retailers. Corresponding reference products were identified based on claim criteria specified by the Canadian Food Inspection Agency. Differences in energy, macronutrient content and key ingredients involved in sugars reformulation were assessed between claim and reference products.ResultsA total of 111 baked goods and 23 breakfast cereal products were included. No significant difference was found in mean energy content between the claim and reference products for all subcategories, except for “unsweetened” baked goods, where the energy content in claim products was significantly higher than that of the reference products (p &lt; 0.001). Specifically, 49% of products with claims of “no added sugar,” 27% of “sugar-free,” and 23% of “lower/reduced in sugar” had higher energy content compared to corresponding reference products. Sugar alcohols, dietary fibers, non-nutritive sweeteners and starch were the top ingredients used in place of added sugars in claim products.ConclusionNo significant difference in mean total energy content (per 100 g) between baked goods and breakfast cereals carrying sugars-related claims was found, despite various sugar reduction strategies. Thus, these claims could be misleading to consumers who expect such products to be lower in total calories. Food manufacturers are encouraged to reformulate products with improved calorie and nutrition profiles rather than using a single-nutrient focus. Consumers education on these issues can help them be mindful of the presence and unintended consequences of common sugar-replacement practices.
Brazilian real-world data of immunotherapy in extensive stage small cell lung cancer
Authors: Duarte Flavia A. , Dienstmann Rodrigo , Diniz Paulo H. C. , e Silva Matheus C. , Veloso Gilson G. V. , Arcanjo Georgia S. , Paes Rafael , Montella Tatiane C. , Lima Helena F. C. A. , Ferrari Bruno L. , Macuzo Eliane V. , Ferreira Carlos G. 
Published: February 2025

IntroductionThe landmarks of Thoracic Oncology in the last two decades have been accompanied by exponential growth in costs, making it imperative to assess the real benefit of incorporating new technologies. Combining immunotherapy (IO) with platinum-etoposide chemotherapy has become the standard of care in first-line treatment of extensive-stage small cell lung cancer (ES-SCLC). However, the absolute difference in overall survival (OS) has reached three months. This study aimed to investigate the impact of this intervention in a real-world cohort.Material and methodsWe retrospectively analyzed data from ES-SCLC patients (pts) from a Brazilian Oncology Group, diagnosed and treated between January 2018 and June 2022. The primary objectives were median OS (mOS) and median time to subsequent treatment (mTST) according to IO exposure in the first-line setting. Secondarily, we intend to compare these results with the literature data and with an internal and contemporary cohort of patients treated with chemotherapy alone.ResultsIn total, 85 SCLC patients were included in this analysis. The median follow-up was nine months. First line regimens were atezolizumab + platinum-etoposide in 53%, platinum-etoposide in 36% and platinum-irinotecan in 11%. Among ES-SCLC pts who received IO in their first-line treatment, the mOS was 15.0 months (95% CI: 11.20; 18.80) and the mTST was 8.0 months (95% CI: 6.25; 9.75). As a reference, our internal and contemporary control presented numerically lower mOS and mTST: 9.0 months (95% CI: 2.08; 19.92) and 7.0 months (95% CI: 5.88; 8.12), respectively.DiscussionFew real-world cohorts are evaluating the impact of IO in ES-SCLC, limited to high-income countries. Our data suggest that IO has a meaningful impact on the outcome of ES-SCLC in daily clinical practice, confirming previous trial results.
Retrospective BReast Intravoxel Incoherent Motion Multisite (BRIMM) multisoftware study
Authors: Basukala Dibash , Mikheev Artem , Li Xiaochun , Goldberg Judith D. , Gilani Nima , Moy Linda , Pinker Katja , Partridge Savannah C. , Biswas Debosmita , Kataoka Masako , Honda Maya , Iima Mami , Thakur Sunitha B. , Sigmund Eric E. 
Published: February 2025

IntroductionThe intravoxel incoherent motion (IVIM) model of diffusion weighted imaging (DWI) provides imaging biomarkers for breast tumor characterization. It has been extensively applied for both diagnostic and prognostic goals in breast cancer, with increasing evidence supporting its clinical relevance. However, variable performance exists in literature owing to the heterogeneity in datasets and quantification methods.MethodsThis work used retrospective anonymized breast MRI data (302 patients) from three sites employing three different software utilizing least-squares segmented algorithms and Bayesian fit to estimate 1st order radiomics of IVIM parameters perfusion fraction (fp), pseudo-diffusion (Dp) and tissue diffusivity (Dt). Pearson correlation (r) coefficients between software pairs were computed while logistic regression model was implemented to test malignancy detection and assess robustness of the IVIM metrics.ResultsDt and fp maps generated from different software showed consistency across platforms while Dp maps were variable. The average correlation between the three software pairs at three different sites for 1st order radiomics of IVIM parameters were Dtmin/Dtmax/Dtmean/Dtvariance/Dtskew/Dtkurt: 0.791/0.891/0.98/0.815/0.697/0.584; fpmax/fpmean/fpvariance/fpskew/fpkurt: 0.615/0.871/0.679/0.541/0.433; Dpmax/Dpmean/Dpvariance/Dpskew/Dpkurt: 0.616/0.56/0.587/0.454/0.51. Correlation between least-squares algorithms were the highest. Dtmean showed highest area under the ROC curve (AUC) with 0.85 and lowest coefficient of variation (CV) with 0.18% for benign and malignant differentiation using logistic regression. Dt metrics were highly diagnostic as well as consistent along with fp metrics.DiscussionMultiple 1st order radiomic features of Dt and fp obtained from a heterogeneous multi-site breast lesion dataset showed strong software robustness and/or diagnostic utility, supporting their potential consideration in controlled prospective clinical trials.
Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway
Authors: Li Tianyao , Chen Jiaxin , Xie Zhouyuan , Fang Jiansong , Wu Qiqing , Cao Xinyue , Chen Ziying , Wang Yiyun , Fan Qiqi , Wang Qi , Liu Jinman 
Published: February 2025

IntroductionGinseng, known as the “king of herbs,” has long been used in traditional Chinese medicine due to its beneficial properties, including anti-aging, anti-inflammatory, and anti-apoptotic effects. Ginsenosides, the active compounds in ginseng, have shown promise in treating neurodegenerative diseases such as Alzheimer’s disease (AD). This study investigates the therapeutic potential of Ginsenoside Ro and its underlying mechanisms in AD treatment.MethodsIn this study, male APP/PS1 transgenic mice were divided into five groups and treated with Ginsenoside Ro or ginseng for one month. Cognitive function and anxiety were assessed through behavioral tests, including the open field test (OFT) and Morris water maze (MWM). To evaluate Aβ deposition, neuronal apoptosis, neuroinflammation, and the MAPK pathway, various techniques were employed: Thioflavin-T staining, Nissl staining, immunofluorescence, Western blot, and qRT-PCR analyses.ResultsGinsenoside Ro significantly improved cognitive function and reduced anxiety in APP/PS1 mice. It also decreased Aβ deposition and ameliorated neuronal apoptosis in the cerebral cortex. The treatment regulated the expression of pro-apoptotic proteins (Bax and Caspase3) and increased the anti-apoptotic protein Bcl-2. Additionally, Ginsenoside Ro reduced neuroinflammation by decreasing IBA1-positive microglia and GFAP-positive astrocytes and lowering pro-inflammatory cytokines while enhancing anti-inflammatory cytokine IL-10. Furthermore, the phosphorylation levels of p38 and JNK in the MAPK pathway were significantly reduced, suggesting a key mechanism for its therapeutic effects.DiscussionThese findings provide strong evidence supporting Ginsenoside Ro as a potential therapeutic agent for Alzheimer’s disease. Its effects appear to be mediated through the modulation of the IBA1/GFAP-MAPK pathway, which may offer new insights into AD treatment strategies.
Shuhe granule for insomnia: study protocol for a double-blind, randomized, placebo-controlled trial
Authors: Gao Yu , Chen Xiangbin , Li Yuxi , Shen Yuchuan , Chen Xinyi , Xu Qing , Peng Mengling , Xu Wen , Yuan Jiamin , Hu Yuanyuan , Chen Xiankun , Xu Biyun , Yang Zhimin 
Published: February 2025

IntroductionModern medical treatment of insomnia is often associated with issues like addiction, drug resistance, and a high risk of relapse post drug withdrawal. To tackle these challenges, the Chinese medicine formula Shuhe granule (SHG) has been employed in insomnia treatment at Guangdong Provincial Hospital of Chinese Medicine. Despite this, there is currently a lack of reliable evidence from evidence-based trials to support the widespread use of SHG in insomnia treatment. Therefore, we have developed a randomized controlled trial to assess the efficacy and safety of SHG in insomnia treatment.MethodThis study will be a single-center, double-blind, randomized, parallel group, placebo-controlled clinical trial involving a total of 160 eligible patients aged between 18 and 65. Participants will be randomly assigned to either the intervention group, receiving SHG, or the placebo group receiving placebo granules. Follow-up visits will occur every 2 weeks from baseline to 2 months. The primary outcome is the perceived insomnia severity measured by the Insomnia Severity Index. The secondary outcome measures include the Pittsburgh Sleep Quality Index, Fatigue Severity Scale, Patient Health Questionnaire, Generalized Anxiety Disorder, Visual Fatigue Analogue Scale, Traditional Chinese medicine syndrome score, and Polysomnography.DiscussionThe results of the study are expected to provide evidence of high methodological and reporting quality on the efficacy and safety of SHG for insomnia.Trial Registration Numbershttp://itmctr.ccebtcm.org.cn/, ITMCTR2024000035.
Assessment of metal residues in soil and evaluate the plant accumulation in copper mine tailings of Dongchuan, Southwest China
Authors: Deng Lijuan , Yin Min , Yang Shuanglin , Wang Xiaoyun , Chen Juan , Miao Deren , Yin Genshen , Zhai Shuhua , Su Yuan , Wu Cheng , Ren Zhen 
Published: February 2025

IntroductionThis study aimed to identify suitable plants for remediating metal pollution in copper tailing soil and supporting ecological reclamation in Dongchuan, Yunnan, focusing on three major mining regions: Tangdan, Yinmin, and Lanniping.MethodsThe Nemerow comprehensive pollution index was employed to evaluate the metal contamination levels, and the enrichment and transfer capacities of the dominant plants for Cd, Cu, Pb, and Zn were analyzed to identify remediation candidates.ResultsThe findings revealed severe pollution in the copper tailing soil, with Cu as the primary pollutant, and with a pollution rate of 77.778%. A total of 96 plant species from 42 families and 87 genera were recorded, including 29 dominant species across 17 families and 26 genera, with herbs comprising 62.068% of the dominant types. Among the tested plants, Leucaena leucocephala, Rumex acetosa, Festuca rubra, and Salix balfouriana exhibited significantly higher metal enrichment and transfer capacities, rendering them for ecological restoration. Salix balfouriana with the highest comprehensive membership function score of 5.298 was identified as the preferred species for ecological restoration in the Dongchuan Cu tailing area. Correlation analysis revealed a positive relationship between the metal content in underground plant parts and both the total metal content and organic matter (OM) in the rhizosphere soil, whereas a negative correlation was observed with soil pH.DiscussionThe soil in the Dongchuan Cu tailing area is severely contaminated by metals, mainly Cu. Among the identified plants, S. balfouriana emerged as the most suitable candidate for metal accumulation. This study establishes a comprehensive theoretical framework for the application and promotion of phytoremediation technology in the Dongchuan copper tailings area.
The mediating roles of cognitive emotion regulation and resilience in the association between life events and sleep quality among medical students
Authors: Zhu Bo , Gao Xiao-meng , Zhou Mei , Wang Hong-hong 
Published: February 2025

BackgroundSleep quality in medical students can be influenced by numerous factors including life events, resilience, and cognitive emotion regulation strategies. Understanding the interplay between these factors is crucial for developing effective interventions to enhance medical students’ mental health and well-being.ObjectiveThis study examined the association between life events and sleep quality and explored the mediating roles of resilience and cognitive emotion regulation in this relationship.MethodsThis cross-sectional study included 407 medical students from a university in Central Province, China, surveyed between March 15 and March 20, 2023. We employed the Adolescent Self-Rating Life Events Checklist, the Connor-Davidson Resilience Scale, the Cognitive Emotion Regulation Questionnaire, and the Pittsburgh Sleep Quality Index to assess variables. Data analysis involved descriptive statistics, Pearson correlation, and mediation analysis using the SPSS macro Process.ResultsThe valid participants (N = 407) were from a medical university with a gender distribution of 29.5% male and 70.5% female. Our findings indicate that higher scores on negative life events significantly predict poorer sleep quality. Furthermore, maladaptive cognitive emotion regulation was also a predictor of poor sleep quality, while resilience was positively associated with beneficial cognitive emotion regulation strategies. Notably, resilience and maladaptive cognitive emotion regulation partially mediated the impact of life events on sleep quality.ConclusionThe study highlights that life events significantly affect medical students' sleep quality both directly and indirectly through mechanisms involving resilience and cognitive emotion regulation. These insights are vital for framing interventions to improve psychological resilience and adaptive emotion regulation strategies, thereby enhancing sleep quality and overall mental health in medical students. This research contributes to a deeper understanding of how life events impact sleep quality, offering pathways and conditions that could be targeted in future interventions.
Популяризация китайской оперы на национальном телевидении
Authors: Цао Ц. , Марьина Л.П. 
Published: February 2025

В данной статье сфокусируется на распространении и популяризации китайской оперы на национальном телевидении. В ней анализируются теоретические основы китайской оперы как культурного феномена, ключевая роль телевидения, особенности оперных программ и факторы аудитории. Исследование показывает, что национальное телевидение с помощью разнообразных форм программ и инновационных методов играет центральную роль в наследовании китайской оперы. Различные типы программ имеют свои особенности аудитории. Реалити-шоу о оперном театре имеет приоритет в продвижении оперы и открывают новые пути для художественного развития.
This article focuses on the dissemination and popularization of Chinese opera on national television. It analyzes the theoretical foundations of Chinese opera as a cultural phenomenon, the key role of television, the characteristics of opera programs and audience factors. The study shows that national television plays a central role in the inheritance of Chinese opera through various program forms and innovative methods. Different types of programs have their own audience characteristics. Reality opera shows have priority in promoting opera and open up new paths for artistic development.
Влияние потребления сериалов на образ жизни человека
Authors: Гангалов М.А. , Маглий Е. 
Published: February 2025

В данной статье рассматривается феномен воздействия сериалов на человека, а именно тот факт, что длительное воздействие телесериалов может оказывать как положительное, так и отрицательное воздействие на людей. С одной стороны, просмотр сериалов может обеспечить форму эскапизма и расслабления, позволяя зрителям временно оторваться от стрессов повседневной жизни. Кроме того, некоторые шоу могут разжигать разговоры и развивать социальные связи между зрителями.
The article examines the phenomenon of the impact of TV series on humans, namely the fact that long-term exposure to TV series can have both positive and negative effects on people. On the one hand, watching TV shows can provide a form of escapism and relaxation, allowing viewers to temporarily break away from the stresses of everyday life. Additionally, some shows can spark conversations and develop social bonds between viewers.