bluuebunny/crossref_metadata_2025_split huggingface dataset:
(261) IMPACT OF A PROGRAM OF INTRODUCTION TO CLINICAL SEXOLOGY IN THE FIRST CYCLE OF MEDICAL STUDIES ON THE KNOWLEDGE OF STUDENTS
Authors: Ons Kaabia , Rim Bouchahda , Raouf Ben Abdesslem , Ryadh Ncibi , Khouloud Ikridih , Anouar Chaieb 
Published: July 2023

Abstract

Objectives
Sexual health is a pillar of young adult health. For medical students, one of whose training objectives is to educate the population about sexual health, it is necessary to check their basic knowledge, correct it and deepen it through an academic program. This work proposes to evaluate the impact of an initiation program in clinical sexology on the knowledge of learners in matters of sexuality.

Methods
This is a quasi-experimental study conducted on a random sample of students from our Faculty of Medicine who have followed the one-semester program of introductory training in clinical sexology in the second year of the first cycle of medical studies via a questionnaire validated by the line of professional development of the same Faculty.

Results
The intervention reached 245 students, 61 of whom completed the questionnaires concerning knowledge before and after the intervention with a follow-up of 2 years; i.e. a participation rate of 24.89%. Following the intervention, learners better discern the different fields of sexuality (78.7 vs 98.4%; p = 0.002), the notions of sexual pleasure and orgasm (78.7 vs 93.3%; p = 0.004). Similarly, they know better the means of contraception (78.7 vs 96.7%; p = 0.000), the normal course of pregnancy and childbirth (78.7 vs 93.3%; p = 0.004) as well as the sources of information to personal questions about their own sexuality (54.1 vs 72.1%; p = 0.019). Some false beliefs persist despite the intervention, such as the fact that masturbation is a pathological act (32.8 vs 34.4%; p = 0.791).

Conclusions
An introduction to clinical sexology in the curriculum of the 1st cycle of medical studies is useful for the training of a good doctor but cannot compensate for the shortcomings of a comprehensive sex education program.

Conflicts of Interest
Nothing to declare.
(205) SEXUAL EXPERIENCES OF TRANSGENDER PEOPLE IN POLAND
Authors: Katarzyna Zborowska , Daria Jorg , Bożena Chrapkiewicz , Prof. Violetta Skrzypulec-Plinta 
Published: July 2023

Abstract

Objectives
Transgender people may face serious challenges with their sexual experiences such as sexual behavior (ie the type and frequency of sexual activity) and sexual experience (eg their sexual pleasure) at various stages of the diagnosis and treatment process. The aim of the study was to assess sexual behavior, to assess the quality of sexual life at various stages of the process of diagnosis and treatment of transgender people.

Methods
104 transgender people who are sexually active were qualified for the study. The study was conducted in two medical centers. The research tool used in the study was the original questionnaire and the Life Satisfaction Scale (SWLS), the Sexual Satisfaction Questionnaire (KSS).

Results
The author's study also showed that both transgender women and transgender men after SRS achieve statistically higher results on the KSS scale compared to people before surgical gender reassignment. Moreover, it was found that trans people who accept their genitals have statistically higher scores of sexual satisfaction. There was no correlation between SRS and the stage of the diagnosis and treatment process and the act of masturbation. Additionally, it was indicated that transsexual people who experienced homosexual intercourse before legal gender reassignment had a higher sexual satisfaction score.

Conclusions
Transgender women are characterized by a higher sense of life satisfaction than transgender men at every stage of the diagnosis and treatment process. Transgender men are characterized by a higher assessment of sexual satisfaction during hormone treatment after legal gender correction in relation to transgender women. Surgical sex reassignment operations determine the assessment of sexual satisfaction among transgender people.

Conflicts of Interest
No Conflicts of Interest.
(329) HOW MANY TRANSGENDER PEOPLE ARE THERE IN ITALY? A POPULATION-BASED STUDY (THE SPOT STUDY)
Authors: Dr. Jiska Ristori , Dr. Marina Pierdominici , Dr. Matteo Marconi , Dr. Luisa Brogonzoli , Prof. Giovanni Castellini , Dr. Francesco Cipriani , Dr. Carlotta Cocchetti , Dr. Alessia Romani , Dr. Francesca Mazzoli , Prof. Mario Maggi , Dr. Alessandra Fisher 
Published: July 2023

Abstract

Objectives
The proportion of transgender population is growing. In Italy, the only available study dates back to 2011 and focuses on adult transgender population who underwent gender-affirming surgical treatment, thus underestimating transgender population size. Studies on the general population represent an urgent health issue.

Methods
A population-based study using a self-administered on-line questionnaire filled out anonymously was carried out. The survey included assessments of socio-demographic characteristics. Gender incongruence (GI) was evaluated by using the 2-item approach assessing gender assigned at birth and gender identity (male, female, both, neither, other). For people who identified as transgender the survey also included questions about the age of first awareness of one’s gender identity and the wish and/or history of gender affirming path.

Results
A total of 20.490 questionnaires were obtained online. Medium age of responders was 35.1±11.5 years old. The 9.9% of assigned male at birth (AMAB) and the 7.8% of assigned female at birth (AFAB) reported a transgender identity: among AMAB people, the 43.3% reported a full female gender identification, the 31% identified as both man and woman, 9.2% neither, and 16.4% other. Among AFAB people, the 39.3% reported a full male gender identification, the 26.4% identified as both man and woman, 19.4% neither, and 14.9% other. AMAB and AFAB trans people reported early awareness of GI. Among AMAB trans people, 46.2% does not wish legal name change, 35.6% hormonal treatment, and 41.7% surgical procedures. Among AFAB trans people, 40% does not wish legal name change, 39.1% hormonal treatment, and 34.5% surgical procedures.

Conclusions
Our results show higher percentages of transgender people in the general population compared to previously published studies. The number of non-binary trans population was consistent with previous data. Overall, these results could be considered as a first step towards a more effective Italian health planning in order to properly address transgender health care needs.

Conflicts of Interest
The authors declare no conflict of interest.
Liberius on Athanasius at Arles, Milan, and in Constantius’ Court
Authors: McCashen Grayden 
Published: July 2023

Abstract
Liberius is often viewed as Athanasius’ ally in the mid-350s, but his own writing, contemporary testimony, and the pagan historian Ammianus Marcellinus suggest otherwise. Rather than defending Athanasius at the councils of Arles and Milan and in Constantius II’s court, Liberius attempted to establish acceptable conditions for peace in the Church by trading Athanasius’ excommunication, which he saw as justified by Athanasius’ refusal to comply with traditional ecclesial-judicial procedures, for doctrinal concessions from certain Eastern bishops whom Liberius suspected of sympathizing with heretical doctrine.
Monitoring SDG localisation: an evidence-based approach to standardised monitoring frameworks
Authors: Ciambra Andrea , Siragusa Alice , Proietti Paola , Stamos Iraklis 
Published: July 2023

Abstract
This article studies closeness between indicators that local governments use to monitor Sustainable Development Goal (SDG) implementation in their Voluntary Local Reviews (VLRs) and those included in the standardised set of indicators of the European Handbook for SDG Voluntary Local Reviews. To do so, it develops an index of ‘indicator proximity’ through a qualitative semantic comparison between 2354 indicators used in a sample of 29 VLRs and the 72 indicators included in the Handbook’s standardised set. The index includes absolute and relative scores, taking into consideration size, comprehensiveness and diversity of the indicator sets included in the sample, as well as the methodological features of the Handbook’s set. The index allows to identify the VLRs with higher or lower proximity to the indicators in the standardised set and the SDGs that elicit a higher or lower degree of closeness between standard metrics and indicators selected or defined by local governments. The output shows that VLRs and the Handbook have an overall significant degree of proximity; that variables such as local government type or size or the size of VLR indicator sets do not provide additional explanation for proximity; and that SDGs that can be monitored with locally accessible and affordable data elicit higher indicator proximity.
Density jump as a function of magnetic field strength for perpendicular collisionless shocks with anisotropic upstream pressure
Authors: Bret Antoine 
Published: July 2023

ABSTRACT
Shock waves are common in astrophysical environments. On many occasions, they are collisionless, which means they occur in settings where the mean free path is much larger than the dimensions of the system. For this very reason, magnetohydrodynamic (MHD) is not equipped to deal with such shocks, be it because it assumes binary collisions, hence temperature isotropy, when such isotropy is not guaranteed in the absence of collisions. Here, we solve a model capable of dealing with perpendicular shocks with anisotropic upstream pressure. The system of MHD conservation equations is closed assuming the temperature normal to the flow is conserved at the crossing of the shock front. In the strong shock sonic limit, the behaviour of a perpendicular shock with isotropic upstream is retrieved, regardless of the upstream anisotropy. Generally speaking, a rich variety of behaviours is found, inaccessible to MHD, depending on the upstream parameters. This work can be viewed as the companion paper of MNRAS 520, 6083-6090 (2023), where the case of a parallel shock was treated. Differences and similarities with the present case are discussed.
Optimization of the SVOM satellite strategy for the rapid follow-up of gravitational wave events
Authors: Ducoin J -G , Desoubrie B , Daigne F , Leroy N 
Published: July 2023

ABSTRACT
The SVOM satellite, to be launched in early 2024, is primarily devoted to the multiwavelength observation of gamma-ray bursts and other higher-energy transients. Thanks to its onboard Microchannel X-ray Telescope and Visible-band Telescope, it is also very well adapted to the electromagnetic follow-up of gravitational wave events. We discuss the SVOM rapid follow-up strategy for gravitational wave trigger candidates provided by LIGO-Virgo-KAGRA. In particular, we make use of recent developments of galaxy catalogues adapted to the horizon of gravitational wave detectors to optimize the chance of counterpart discovery. We also take into account constraints specific to the SVOM platform. Finally, we implement the production of the SVOM observation plan following a gravitational wave alert and quantify the efficiency of several optimizations introduced in this work.
The Grounding Mystique
Authors: Sidelle Alan 
Published: July 2023

AbstractGrounding has become all the rage in recent philosophical work and metaphilosophical discussions. While I agree that the concept of ground marks something useful, I am skeptical about the metaphysical weight many imbue it with, and the picture of ‘worldly layering’ that grounding talk inspires. My skepticism centers around the fact that grounding involves necessitation, combined with reasons for thinking matters of necessity are matters of logical or conceptual (semantic, psychological) relations. I sketch an argument for deflationism about ground based on this sort of deflationism about necessity and essence. I also note that in at least some cases, the considerations supporting modal deflationism directly support deflationism about whatever grounding relations may obtain in these cases.
A case of immunoglobulin G4–related retroperitoneal fibrosis and hypophysitis with antecedent respiratory disease followed by spontaneous remission and recurrence
Authors: Sakai Masato , Ohno Yuta , Kozuki Nana , Kawasaki Yuki , Yoshida Michiko , Ikeda Hiroyuki , Konishi Junji , Maeda Toshiki , Sugano Motoki , Kawakami Satoshi , Ito Isao , Yamaguchi Aina , Naiki Hironobu , Notohara Kenji , Akamizu Takashi , Kawano Mitsuhiro , Yoshida Haruyoshi 
Published: July 2023

ABSTRACT
A 65-year-old man presented with apparent bronchopneumonia. After treatment with antibiotics, he showed eosinophilia. Computed tomography (CT) imaging revealed bilateral consolidation, ground-glass opacities with nodular consolidations, and pleural effusion. Lung biopsy showed organising pneumonia with lymphoplasmacytic infiltration in the alveolar septa and in the thickened pleura and interlobular septa. All pulmonary abnormalities spontaneously went into remission within 12 months. At 73 years old, a follow-up CT scan revealed small nodules in both lungs and the review of the head CT scan showed thickening of the pituitary stalk in studying prolonged headache. Two years later, he visited the hospital complaining of severe oedema on the lower extremities with high serum immunoglobulin (Ig)G4 186 mg/dl. A whole-body CT scan showed retroperitoneal mass surrounding aortic bifurcation and compressing inferior vena cava, pituitary stalk thickening and gland swelling, and enlarged pulmonary nodules. Anterior pituitary stimulation tests showed central hypothyroidism, central hypogonadism, and adult growth hormone deficiency with partial primary hypoadrenocorticism. Retroperitoneal mass biopsy showed storiform fibrosis and obliterative phlebitis with marked lymphoplasmacytic infiltration with moderate IgG4-positivity. Immunostaining of the former lung specimen revealed dense interstitial infiltration of IgG4-positive cells. These findings indicated metachronous development of IgG4-related disease in lung, hypophysis, and retroperitoneum, according to the recent comprehensive diagnostic criteria of IgG4-related disease. Glucocorticoid therapy ameliorated oedema, on the other hand, unmasked partial diabetes insipidus at the initial dose of the treatment. Hypothyroidism and retroperitoneal mass regressed at 6 months of the treatment. This case warns us that long-term follow-up from prodromal to remission is necessary for the treatment of IgG4-related disease.
Aligning Kitwood’s Model of Person-Centered Dementia Care with Music Therapy Practice
Authors: Kelly Lisa , Ahessy Bill , Richardson Ita , Moss Hilary 
Published: July 2023

Abstract
Person-centered dementia care has been extensively integrated into music therapy practice; its central aim being to meet the core psychological needs of people with dementia, uphold personhood, and contribute to enhanced quality of life. Furthermore, Kitwood’s model has been widely referenced as the theoretical framework underpinning multiple studies with people with dementia. However, few studies explore it in more concrete terms, expand on how it is implemented in practice, or describe how “positive person work” can be facilitated in music therapy with this population. This paper aims to address these lacunae, by presenting a comprehensive overview of Kitwood’s model; identifying how it has informed music therapy practice, and highlighting current applications of “person-centered music therapy” in relation to meeting the core psychological needs of people with dementia. Furthermore, the authors present practical considerations on facilitating “positive person work” in music therapy, drawing on their experiences of providing music therapy in dementia care.
Prediction of cognitive scores by joint use of movie-watching fMRI connectivity and eye tracking via Attention-CensNet
Authors: Gao Jiaxing , Zhao Lin , Zhong Tianyang , Li Changhe , He Zhibin , Wei Yaonei , Zhang Shu , Guo Lei , Liu Tianming , Han Junwei , Jiang Xi , Zhang Tuo 
Published: July 2023

Abstract

Background
Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states, such as rest and doing tasks. Nevertheless, the state-of-the-art methods have found it difficult to achieve desirable results from movie-watching paradigm functional magnetic resonance imaging (mfMRI) -induced brain functional connectivity, especially when there are fewer datasets. Incorporating other physical measurements into the prediction method may enhance accuracy. Eye tracking, becoming popular due to its portability and lower expense, can provide abundant behavioral features related to the output of human's cognition, and thus might supplement the mfMRI in observing participants’ subconscious behaviors. However, there are very few studies on how to effectively integrate the multimodal information to strengthen the performance by a unified framework.

Objective
A fusion approach with mfMRI and eye tracking, based on convolution with edge-node switching in graph neural networks (CensNet), is proposed in this article.

Methods
In this graph model, participants are designated as nodes, mfMRI derived functional connectivity as node features, and different eye-tracking features are used to compute similarity between participants to construct heterogeneous graph edges. By taking multiple graphs as different channels, we introduce squeeze-and-excitation attention module to CensNet (A-CensNet) to integrate graph embeddings from multiple channels into one.

Results
The proposed model outperforms those using a single modality and single channel, and state-of-the-art methods.

Conclusions
The results indicate that brain functional activities and eye behaviors might complement each other in interpreting trait-like phenotypes.
Development and application of a scoring system for septum injuries in beef calves with and without a nose flap
Authors: Kirk A A , Tucker C B 
Published: July 2023

Abstract
The weaning period is a stressful time for beef calves because they must quickly gain independence from their dam. Gradual methods of weaning, such as when the calf is fitted with a nose flap to prevent suckling, are known to reduce the behavioral and physiological indicators of stress. Nose flaps are held in place by the nasal septum and are worn for 4 to 7 d. In the present study, the objectives were to 1) identify if a plastic nose flap worn for 7 d caused nasal injuries, (2) identify if factors like calf body weight or septum size predict injuries or flap loss, and (3) create a scoring system that could reliably score wound characteristics. Eighty-two (N = 82) Angus and Angus–Hereford crossbred beef calves were randomly assigned to ‘Flap’ or ‘No Flap’ treatments. Calves weighed 247 ± 29 kg and those with a flap had septums that were 39 ± 2 mm (mean ± SD). Images were taken of each nostril before flap insertion, on the day of removal, and 6 d after removal. Wounds were scored for the presence/absence of three characteristics in either nostril: damage (tissue where the flap rested was a different color than surrounding nostril), impression (edges of the wound were clearly raised or sunken), and blood. One trained observer scored a subset of photos (N = 64) twice, in a consistent manner for all three characteristics (damage, impression, and blood; 97%, 91%, and 100% agreement between 1st and 2nd evaluations, respectively), indicating that our system is repeatable. Thirty-two percent of calves in the Flap treatment lost their flap before the day of removal. No calves in the No Flap treatment were injured. All animals that kept their flap in for 7 d had damage and impressions in at least one nostril and 86% of calves had blood present immediately after nose flap removal (P ≤ 0.001 compared to No Flap) indicating that the flaps altered the nasal tissue and created open wounds. Six d after flap removal, 100% still had visible damage, 64% had impressions, and 29% had blood, indicating that while damage is longer lasting, wounds can start to repair after the flap is removed. Injuries were prevalent in all calves, thus there was no relationship between calf size (body weight or septum width) on these wounds (P ≥ 0.374). Body weight or septum size did not differ (P ≥ 0.489) between calves that kept or lost their flap. Injuries inflicted from a nose flap may counteract the previously documented benefits of this method of weaning, making it less advantageous than alternatives and raise concerns about other uses of these devices in other contexts.
Automatization of metabolite extraction for high-throughput metabolomics: case study on transgenic isoprene-emitting birch
Authors: Bertić Marko , Zimmer Ina , Andrés-Montaner David , Rosenkranz Maaria , Kangasjärvi Jaakko , Schnitzler Jörg-Peter , Ghirardo Andrea 
Published: July 2023

AbstractMetabolomics studies are becoming increasingly common for understanding how plant metabolism responds to changes in environmental conditions, genetic manipulations and treatments. Despite the recent advances in metabolomics workflow, the sample preparation process still limits the high-throughput analysis in large-scale studies. Here, we present a highly flexible robotic system that integrates liquid handling, sonication, centrifugation, solvent evaporation and sample transfer processed in 96-well plates to automatize the metabolite extraction from leaf samples. We transferred an established manual extraction protocol performed to a robotic system, and with this, we show the optimization steps required to improve reproducibility and obtain comparable results in terms of extraction efficiency and accuracy. We then tested the robotic system to analyze the metabolomes of wild-type and four transgenic silver birch (Betula pendula Roth) lines under unstressed conditions. Birch trees were engineered to overexpress the poplar (Populus × canescens) isoprene synthase and to emit various amounts of isoprene. By fitting the different isoprene emission capacities of the transgenic trees with their leaf metabolomes, we observed an isoprene-dependent upregulation of some flavonoids and other secondary metabolites as well as carbohydrates, amino acid and lipid metabolites. By contrast, the disaccharide sucrose was found to be strongly negatively correlated to isoprene emission. The presented study illustrates the power of integrating robotics to increase the sample throughput, reduce human errors and labor time, and to ensure a fully controlled, monitored and standardized sample preparation procedure. Due to its modular and flexible structure, the robotic system can be easily adapted to other extraction protocols for the analysis of various tissues or plant species to achieve high-throughput metabolomics in plant research.