bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CRB and inflammatory parameters in myocardial infarction (STEMI-NSTEMI) and relationship with infarct site, significance and complication
Authors: Marwan Chamieh , Zgib Bshar AL- , hammoud Ahmad , AL-Fawares Maamoun 
Published: February 2023

Abstract

Background
The first few hours before going to the hospital are the most dangerous for a person having a heart attack. Death can occur during this period in 20–30% of people who have a heart attack, so it is necessary to seek immediate medical care when people suspect that they are having a heart attack. This research aims to study and measure the levels of certain substances (called markers). cardiac markers and inflammatory markers, and a comparison of their mean between the two types of infarction.
Methods and materials:
This study was conducted on 100 male and female patients from Damascus Hospital, where all patients with myocardial infarction (STEMI-NSTEMI) who met inclusion and exclusion criteria were admitted and our study relied on the retrospective and cross sectional study method.
Results
The sample included 100 male and female patients, all of whom had myocardial infarction (STEMI-NSTEMI), where the percentage of males in the study was 78% and the percentage of females was 22%. The mean of age of the patients was 55.47 years with a standard deviation of 10.318 years. The percentage of smokers was 63%. as for the type of infarction, the majority were Patients have STEMI type, and by studying the relationships, it was found that there was no statistically significant relationship between the type of infarction and the medical history, and between the type of infarction and complications, where p.value > 0.05.
Conclusion
There are statistically significant differences when comparing the mean values of C-reactive protein (CRB) in the two types of infarction (STEMI-NSTEMI). The product of fibrin degradation (D. dimer) in the two types of infarction (STEMI-NSTEMI) where p.value < 0.05.
The clinical significance of Zinc finger protein 2 in laryngeal squamous cell carcinoma and its potential mechanism
Authors: Lin Caixing , Mo Miao , Liang Yong , Huang Suning , Ding Hua , Jiang Li , Zhang Tingting , Fang Yeying , Yan Dongmei , Wu Jiyun , Niu Yitong , Wu Xiaowei , Wei Zhuxin 
Published: February 2023

Abstract
Backgrand: Laryngeal squamous cell carcinoma (LSCC), which arises from the laryngeal mucosa, is the main type of laryngeal cancer. An influence of Zinc finger protein 2 (ZIC2) expression on the occurrence and progression of LSCC has not been established. We aim to identify the clinical importance of ZIC2 expression in LSCC and to explore its latent potential mechanisms.
Methods:In this study, we studied the relationship between protein and mRNA expression of ZIC2 in LSCC and clinical pathological features and prognoses via mining the high-throughput sequencing data from multiple databases and to use immunohistochemistry (IHC) and integrated analysis. Meanwhile the downstream targets of ZIC2 transcription factor were also predicted with ChlP-seq data. The KEGG, GO and PPI analysis were applied to identified the potential mechanism of ZIC2 in LSCC. After constructing ZIC2 stable expression cells, we attempt to disclose an association between ZIC2 and cell cycle and apoptosis with RT-qPCR and Western blot methods. Cell cycle was detected by flow cytometry.
Results: A higher ZIC2 expression in LSCC were found in both protein and mRNA level by integrated analysis (standard mean difference, SMD=1.76 (95% CI, 1.34–2.18)). The IHC staining of ZIC2 protein is nuclear in LSCC. Kinesin family member 14 (KIF14) was explored as the potential downstream target gene of ZIC2. ZIC2 has a binding peak before the transcription start site of KIF14 and their expression were positively correlated with each other. The expression of KIF14 was elevated after overexpressing ZIC2. The KEGG analysis revealed that ZIC2 may involve LSCC by cell cycle. Cell cycle testing revealed that in ZIC2 knockdown cells, G1 phase increased while S phase was decreased. After knockdown ZIC2 expression, the expression of P21 was elevated, Bax protein was increased while Bcl2 decreased. The analysis of the summary receiver operating characteristic (sROC) demonstrated that ZIC2 may have potential to become a diagnostic marker for LSCC.
Conclusions: In conclusion, up-regulation of ZIC2 may contribute to LSCC pathogenesis in cell cycle pathway and it may target KIF14 in LSCC, but these need further research in the future.
A Machine Learning-based Optimization Approach for Pre-copy Live Virtual Machine Migration
Authors: Haris Raseena M , Khan Khaled M , Nhlabatsi Armstrong , Barhamgi Mahmoud 
Published: February 2023

Abstract
Organizations widely use cloud computing to outsource their computing needs. One crucial issue of cloud computing is that services must be available to clients at all times. However, the cloud services may be temporarily unavailable due to maintenance of the cloud infrastructure, load balancing of services, defense against cyber attacks, power management, proactive fault tolerance, or resource usage. The unavailability of cloud services impacts negatively on the business model of cloud providers. One solution to tackle the service unavailability is Live Virtual Machine Migration (LVM), that is, moving virtual machines (VMs) from the source host machine to the destination host without disrupting the running application. Pre-copy memory migration is a common LVM approach used in most networked systems such as the cloud. The main difficulty with this approach is the high rate of frequently updating memory pages, referred to as "dirty pages. Transferring these updated or dirty pages during the pre-copy migration approach prolongs the total migration time. After a predefined iteration, the pre-copy approach enters the stop-and-copy phase and transfers the remaining memory pages. If the remaining pages are huge, the downtime or service unavailability will be very high -resulting in a negative impact on the availability of the running services. To minimize such service downtime, it is critical to find an optimal time to migrate a virtual machine in the pre-copy approach. To address the issue, this paper proposes a machine learning-based method to optimize pre-copy migration. It has mainly three stages (i) Feature selection (ii) Model generation and (iii) Application of the proposed model in pre-copy migration. The experiment results show that our proposed model outperforms other machine learning models in terms of prediction accuracy and it significantly reduces downtime or service unavailability during the migration process.
WITHDRAWN: Tribological behavior characterization, fault detection and health evaluation of mechanical seals based on face vibration acceleration measurement
Authors: Wang Qingfeng , Song Yunfeng , Li Hua , Shu YUE , Xiao Yang 
Published: February 2023

Abstract
Aiming at the performance degradation caused by the wear of the face of the contacting mechanical seal during operation, and the lack of effective monitoring methods and evaluation indicators for predictive maintenance, a mechanical seal test rig was built. The vibration and closing force signals of the seal face were collected. The relationship between the closing force with the phase change law and the performance degradation of the face was clarified. The vibration characteristic parameters of the face were studied and the vibration sensitive characteristics of the time domain, frequency domain and time-frequency domain were screened. The incipient fault detection method and degradation assessment method of mechanical seals were studied. The results show that the circumferential variation of the closing force can characterize the performance degradation degree of the mechanical seal. With the increase of the face wear, the maximum face closing force changes from regular to random with the phase. The mean value, fuzzy entropy, and permutation entropy of the vibration signal of the seal face can characterize the degree of performance degradation of the mechanical seal. The incipient fault time of the mechanical seal can be identified by the incipient fault detection model. The health status of the mechanical seal can be clearly divided by the performance degradation assessment model, which provides a basis for predictive maintenance of the mechanical seal.
Influencing Learning: How Instagram can Play a Role in Anesthesia Education
Authors: Amaya Sebastian , Pérez Martha Lucía Gutiérrez , Deluquez Marcelino Murillo , Valle Anacaona Martinez del , Fayad Nashla Fayad 
Published: February 2023

Abstract
Purpose
To determine what influence our instagram account, @accigunbosque, can have on the spread of medical knowledge, as well as the impact it may have on the actual learning process, in order to describe the utility of these accounts on social media within the medical community.
Methods
A longitudinal, prospective, descriptive study and a narrative perception analysis. Interaction data was recollected for 26 weeks, and evaluations were carried out with 2 posts from the page, in order to assess the quality of interaction with educational material. The differences between before and after scores of the participants in the educational modules were calculated with the Wilcoxon signed-rank test for related samples. Finally, the texts of comments from publications were analyzed with NVivo11.
Results
The page generated 48 infographic posts and held 3 webinars throughout the study period. The maximum number of accounts reached was 15,368, the average number of visits to the profile was 380, the average amount likes received on posts was 316, and the maximum number of saves was 414. The median of comments per publication was 3, ranging from none to a maximum of 27. Participation in the quizzes was 16/568 and 3/502, and a significant difference was found (p = 0.024) in the first quiz. The content of 186 comments was reviewed and only 4% made additional contributions or left constructive remarks, with the rest being composed of emoticons and admiration.
Conclusions
For means of data sharing, Instagram can be a very useful tool as seen within our study. However, the actual learning process behind Instagram may prove to be deficient, considering the little participation in our two educational modules. This allows one to hypothesize that many Instagram users are likely to passively view and interact with educational Instagram posts, but may not actively retain information as expected.
Geochemical characterization and WQI based assessment of groundwater quality Using GIS in tropical river basin: Case study in Kirama-ara River basin, Southern Province, Sri Lanka.
Authors: Perera T.A.N.T , Dissanayake O.D.I.P , jayasinghe G.Y 
Published: February 2023

Abstract
In the Kirama-ara River basin, Matara, southern region of Sri Lanka, a variety of agricultural inputs are utilized, and flooding is a common hazard. As a result, the complete physicochemical profile of the groundwater in the Kirama-ara river basin is yet undiscovered. Therefore, the goals of this study were to (a) identify the geochemical characteristics and changes in water quality, (b) evaluate non-carcinogenic health risk and develop a GWQI, and (c) generate a spatial distribution map for groundwater physicochemical parameters in the Kirama-ara river basin in Matara, Sri Lanka. The physiochemical characteristics of 16 groundwater samples, including pH, electrical conductivity (EC), total dissolved solids (TDS), Na+, K+, Ca2+, Mg2+, Cl−, NO3−, PO43−, and SO42−, were examined for spatial and temporal variations. The pH, NO3−, and PO43− values of 50%, 6.25%, and 12.5% of the samples, respectively, were determined to be beyond the allowable limit by both the WHO and SLS. The physicochemical investigation demonstrates that while 87.5% of the locations were acceptable for drinking, 12.5% of them lacked sufficient amounts. The most common hydro-chemical facies were Ca2+-Mg2+-HCO3−, mixed Ca2+-Mg2+-Cl− face, and Ca2+-Cl−. Rock weathering has a profound impact on the ionic composition and chemistry of groundwater. Additionally, health risk assessment research conducted in accordance with United States Environmental Protection Agency rules revealed that children face greater health risks than adults. To build reasonable management plans for long-term groundwater quality conservation and public health, more research is required.
Greater physical fitness (Vo2Max) in healthy older adults associated with increased integrity of the Locus Coeruleus-Noradrenergic system
Authors: Plini Emanuele RG , Melnychuk Michael C. , Andrews Ralph , Boyle Rory T. , Whelan Robert , Spence Jeffrey S. , Chapman Sandra B. , Robertson Ian H. , Dockree Paul M. 
Published: February 2023

Abstract

Physical activity (PA) is a key component for brain health and Reserve, and it is among the main dementia protective factors. Robertson proposed that the upregulation of Locus Coeruleus-noradrenergic (LC-NA) system might be a key aspects for building reserve and resilience to neurodegeneration. PA elicits an enhanced catecholamine response, in particular Noradrenaline (NA). By increasing physical commitment, greater amount NA is synthetised in response to higher oxygen demand. More trained individuals show greater capabilities to carry oxygen resulting in greater Vo2max (a measure of oxygen uptake and physical fitness indicator). In the current study, we hypothesised that greater Vo2 max could be related to greater LC-NA MRI integrity. As hypothesised, greater Vo2max related to greater LC integrity across 41 healthy adults (age range 60–72). As a control procedure, when the analyses were repeated for the other neuromodulators’ seeds (Serotonin, Dopamine and Acetylcholine) weaker associations emerged. The newly established link between Vo2max and LC-NA system offers further understanding of the neurobiology underpinning Reserve in relationship to PA. While this study supports Robertson’s theory proposing the upregulation of the noradrenergic system as a possible key factor building Reserve, it also provide ground for increasing LC-NA system resilience to neurodegeneration via Vo2max enhancement.
Performance and resilience of the PolyCera® Titan membrane for industrial wastewater treatment
Authors: Teow Yeit Haan , Zulkifli Ernie , Wikramasinghe S. Ranil 
Published: February 2023

ABSTRACT

This research aims to evaluate the performance of PolyCera® Titan membrane for different wastewater treatment. Membrane filtration of several cycles was conducted in understanding the fouling mechanism, fouling propensity, and defouling potential of the PolyCera® Titan which had not been studied by any other researcher before. The PolyCera® Titan membrane is effective for the treatment of textile industry wastewater, palm oil mill effluent (POME), leachate, and semiconductor-industry wastewater. Rejection of methylene blue (MB) and Congo red (CR) was in the range of 78.76–86.04% and 88.89–93.71%, respectively; 94.72–96.50% NaCl, 96.07–97.62% kaolin, and 97.26–97.73% glucose were rejected from synthetic leachate indicating the removal of TDS, TSS, and COD from the leachate, respectively. Standard blocking and complete model were the best models used to explain the PolyCera® Titan membrane fouling mechanism in all types of wastewater treatment processes with a high R2 value. Physical cleaning with the use of distilled water was able to recover the permeate flux with the flux recovery ratio (FRR) value in the range of 79.2–95.22% in the first cycle, 81.20–98.16% in the second cycle, and 86.09–95.96% in the third cycle.
High Expression of PKMYT1 Predicts Poor Prognosis and Aggravates the
Progression of Osteosarcoma via the NF-κB Pathway in MG63 Cells
Authors: Lu Yang , Li Ping , Zhou Yuandong , Zhang Jian 
Published: February 2023

Background:
Protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) contributes to the proliferative, migratory, invasive and colony forming capabilities of oncocytes. Dysregulated expression of PKMYT1 is associated with numerous malignancies. However, at present, the functional role of PKMYT1 in osteosarcoma is still not clarified.

Objective:
The present study, therefore, aimed to investigate the prognostic value of PKMYT1 in osteosarcoma, and to explore the underlying molecular mechanism(s).

Methods:
To meet this end, the expression level of PKMYT1 in osteosarcoma was measured by immunohistochemical analysis. The prognostic value of PKMYT1 in osteosarcoma was analyzed on the basis of R2: Genomics Analysis and Visualization Platform. The functional role of PKMYT1 was subsequently investigated in MG63 cells by knocking down PKMYT1 expression via lentivirus encoding shRNA. MTT assay, scratch wound and Transwell assays were then used to determine whether PKMYT1 fulfills a role in the proliferative and invasive capabilities of the MG63 cells. Subsequently, the role of PKMYT1 in the apoptosis of the cells was assessed using western blot and immunofluorescence analyses. Finally, to determine whether PKMYT1 exerts its role through the NF κB pathway, fibroblast stimulating lipopeptide 1 (FSL 1) was used as an NF κB activator.

Results:
Compared with normal tissues, osteosarcoma tissues showed a significantly increased level of PKMYT1 expression. The clinical survival analysis indicated that patients with high PKMYT1 expression were associated with lower probabilities of overall survival and metastasis free survival compared with those with low PKMYT1 expression levels. Knockdown of PKMYT1 inhibited the migratory and invasive capabilities of the MG63 cells, and also facilitated their apoptosis. Moreover, the knockdown of PKMYT1 restrained the NF κB pathway in MG63 cells, whereas activating the NF κB pathway ameliorated the effects of silencing PKMYT1 on MG63 cells, suggesting that PKMYT1 functions via the NF κB pathway in MG63 cells.

Conclusion:
Taken together, the results of the present study have shown that a high expression level of PKMYT1 is associated with poor prognosis of osteosarcoma, and that PKMYT1 is able to aggravate the malignant progression of MG63 cells via negatively regulating the NF κB pathway, suggesting that PKMYT1 may be a potential molecular therapeutic target for the treatment of osteosarcoma.
Synthesis, Structure-activity Relationship, and Biological Activity of
Benzimidazole-quinoline: A Review to Aid in the Design of a New Drug
Authors: Datt Vimal , Salahuddin  , Mazumder Avijit , Kumar Rajnish , Singh Himanshu , Yadav Ranjeet Kumar , Shabana Km , Shahar Yar Mohammad , Ahsan Mohamed Jawed 
Published: February 2023

Abstract:
Heterocyclic compounds are fundamental building blocks for developing novel bioactive compounds.
Due to their extensive uses in both industrial and synthetic organic chemistry, quinoline and benzimidazole
have recently become important heterocycles. Clinical trials have investigated quinoline and
benzimidazole analogues to treat a variety of illnesses, including cancer, bacterial and fungal infection,
DNA damage, etc. Medicinal chemists are paying attention to nitrogen-containing hybrid heterocyclic
compounds that have a wide range of therapeutical potential with lesser adverse effects. Many efforts
have been made to find new and more efficient ways to synthesize these molecules. However, microbial
resistance is becoming a major threat to the scientific community; hence, the necessity for the discovery
and development of novel antimicrobial drugs with novel modes of action is becoming highly significant.
One strategy to overcome this problem is to produce hybrid molecules by combining two or more bioactive
heterocyclic moieties in a single molecular platform. Based on established research data on quinoline-
bearing benzimidazole derivatives, it can be concluded that both moieties are used for the synthesis
of promising therapeutically active agents. This present review comprises the synthetic approaches of
biologically active quinolines containing benzimidazole derivatives with their structure-activity relationship
studies to provide an overview of the work done on quinoline derivatives to the medicinal chemist
for future research.
Analysis of the Causes and Experience in the Diagnosis and Treatment of
Meningocele Caused by Sternberg’s Canal of the Sphenoid Sinus: Two
Case Reports and a Review of the Literature
Authors: Guo Ai-Shun , You Wei , Lin Zhen-Rong , Wang Yu-Zhe , Wang Wei-Wei , Lin Rui-Sheng , Qiu Shu-Qin 
Published: February 2023

Objective:
The present study aimed to improve the diagnosis and treatment outcome of cerebrospinal fluid (CSF) rhinorrhea caused by patent meningoencephalocele of Sternberg’s canal of the
sphenoid sinus by analyzing the clinical data and imaging features of two rare cases of this disease and
by reviewing the relevant literature for possible etiology, diagnoses, and treatments.

Methods:
Together with the relevant literature, we retrospectively studied the clinical and imaging data
of two patients (mother and child) with CSF rhinorrhea caused by patent meningoencephalocele of
Sternberg’s canal of the sphenoid sinus, analyzed their diagnostic and treatment procedures, and proposed a potential, feasible treatment method.

Results:
On the 2nd day after surgery, the expansive sponge and iodoform gauze in the nasal cavity
were removed in both patients, and the lumbar subarachnoid drainage was removed 3 days after the
operation, as no nasal discharge was observed. One week after the operation, head magnetic resonance
imaging (MRI) showed that the abnormal tissue in the sphenoid sinus had disappeared, and no accumulation of the CSF was observed. Both patients were discharged after 2 weeks. At the time of discharge, both patients were without nasal drip, fever, headache, and other discomforts, and they had
grade 5 muscle strength in their extremities, with normal muscle tension.

Conclusion:
CSF rhinorrhea is usually caused by secondary factors. Spontaneous CSF rhinorrhea
caused by encephalocele of the skull base due to congenital dysplasia of the skull base is very rare and
easily misdiagnosed. The presence of brain tissue or CSF signal in the sphenoid sinus on preoperative
MR images is an important imaging feature of the disease. Conditional cisternography can be used to
further detect CSF leaks. Endoscopic transnasal transsphenoidal repair of CSF leaks combined with
short-term postoperative lumbar subarachnoid drainage is an effective treatment method. According to
previous literature, the possible causes of meningoencephalocele with patent Sternberg’s canal of the
sphenoid sinus include abnormal development of the sphenoid sinus or the craniopharyngeal canal and
bone defects of the skull base. There are no related reports on patent meningoencephalocele caused by
Sternberg’s canal in direct blood relatives, such as mother-son; therefore, the possibility of this disease
having a genetic origin should be considered in future studies on its pathophysiological mechanisms.