bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Potential of Thymoquinone and Caffeic Acid in Experimental Ulcerative Colitis: A Biochemical and Histopathological Investigation
Authors: Ersak Can , Ergüder Ender , Erguder B.Imge , Altiner Saygin , Pekcici M. Recep 
Published: January 2025

Abstract

Aim
This study aims to model ulcerative colitis in rats using acetic acid and monitor colitis development with the "Disease Activity Index (DAI)." Additionally, the clinical, biochemical, and histopathological effects of thymoquinone (TQ) and caffeic acid phenethyl ester (CAPE) on this model are examined.
Materials and Methods
The study used 40 male Wistar Albino rats, weighing between 190–303 grams. The rats were divided into five groups of 8 each: Group 1 (Control) received intraperitoneal 0.9% saline solution for 5 days; Group 2 (Colitis) received acetic acid to induce colitis and 10% ethanol solution intraperitoneally for 5 days; Group 3 (TQ) received acetic acid to induce colitis and intraperitoneal thymoquinone (10 mg/kg/day) for 5 days; Group 4 (CAPE) received acetic acid to induce colitis and intraperitoneal caffeic acid (10 micromol/kg/day) for 5 days; Group 5 (TQ + CAPE) received acetic acid to induce colitis and intraperitoneal thymoquinone and caffeic acid for 5 days. On the 5th day, rats underwent laparotomy under anesthesia, colectomy was performed, and colon samples were taken for biochemical and histological analysis. Serum samples were also collected for biochemical analysis.
Results
Significant differences were observed in the Disease Activity Index, TNF-α, catalase, glutathione peroxidase, IL-10, and MDA, indicating a balance between oxidant and antioxidant parameters. CAPE was found to have a higher anti-inflammatory effect than TQ histopathologically. The combined application of CAPE and TQ showed a synergistic effect, reducing oxidative stress markers and enhancing antioxidant levels.
Conclusion
The hypothesis of this study is that CAPE and TQ will effectively reduce inflammation in an experimental colitis model induced by acetic acid. The results largely support this hypothesis, showing that CAPE has a higher anti-inflammatory efficacy than TQ and that their combined use is more effective in reducing inflammation. These findings suggest that CAPE and TQ could be a potential combination for colitis treatment and should be considered for clinical applications. This study provides new insights into the use of anti-inflammatory agents in experimental colitis models and highlights the potential advantages of combining CAPE and TQ in clinical settings.
Cystitis Glandularis: Analysis of Multiparametric MRI Appearance in 40 Patients.
Authors: Weng Bei , Lin Yingyu , Wen Zhihua , Guo Yan , Wang Huanjun , Kong Lingmin , Cai Qian , Lin Jian 
Published: January 2025

Abstract

Purpose
Cystitis glandularis (CG) is a rare, benign proliferative and metaplastic disorder of the bladder mucosa. However, CG is often confused with bladder cancer due to similar clinical symptoms and imaging findings. The aim of this study was to investigate the multiparametric MRI manifestations of CG, with the goal of improving the diagnostic accuracy of CG.
Methods
Patients with pathologically confirmed CG who underwent pelvic MRI between November 2011 and September 2023 were retrospectively reviewed. The MR imaging characteristics of CG were analyzed and summarized. Additionally, apparent diffusion coefficient (ADC) values were measured to assess the diffusion restriction within the lesions.
Results
A total of 40 patients (mean age, 49.4 years ± 14.4 [SD]; 35 male) with CG were analyzed. The lesions were predominantly located in the trigone and/or bladder neck (36 of 40, [90.0%]). A characteristic multi-layered structure, referred to as the “floating water weeds sign”, was observed in 29 lesions (72.5%) on T2WI, with or without bubble-like high signal intensity. Based on MRI morphology, CG were classified into four types, and most patients showed nodular thickening type (24 of 40, 60.0%). The majority of lesions (34 of 40, 85.0%) exhibited marked enhancement, with 24 patients (60.0%) showing linear contrast enhancement on the lesion surface. Most lesions (36 of 40, 90.0%) showed no or mild diffusion restriction with a mean ADC value of 1.67 ± 0.38×10− 3 mm2/s.
Conclusion
There are several representative characteristic MRI findings for CG, especially on T2WI and DWI, which are valuable for differential diagnosis.
ATOH8 upregulated by IL-6/STAT3 attenuates endoplasmic reticulum stress and promotes oxaliplatin resistance in gastric cancer
Authors: Li Shaowei , Ma Zhenfeng , Li Guanjun , Liu Xiaohan , Wang Jiao , Sun Fei , Liang Bishan , Wang Yawen , Wang Chunlin , Rong Xiaoxiang , Wu Jianhua , Wu Qijing , Shi Yulu , Liao Wangjun , Shi Min , Tan Yujing , Huang Qiong 
Published: January 2025

Abstract

Gastric cancer (GC) is a highly malignant tumor, and oxaliplatin is widely used in its chemotherapy. However, drug resistance limits its clinical effectiveness. This study aimed to identify potential therapeutic strategies to overcome oxaliplatin resistance in GC. RNA sequencing was conducted to compare oxaliplatin-resistant GC cells with their parental counterparts. Using the Limma package, we identified an immunosuppressive microenvironment and six key transcription factors associated with resistance, with ATOH8 showing the most significant correlation with oxaliplatin resistance. Functional assays revealed that ATOH8 expression was linked to increased drug resistance, and its knockout induced upregulation of endoplasmic reticulum (ER) stress-related pathways. Mechanistically, we found that IL-6 facilitated nuclear translocation of STAT3, which subsequently upregulated ATOH8 expression. This established a negative STAT3/ATOH8/ER stress regulatory axis that contributes to chemotherapy resistance. In conclusion, ATOH8 acts as a key regulator of ER stress and chemotherapy resistance in GC. Targeting the STAT3/ATOH8 axis may offer a new therapeutic approach for overcoming resistance in advanced GC.
Diversity and Spatio-seasonal Distribution of Aquatic Macrophytes inMoutore Reservoir, West Bengal
Authors: BISWAS ANUPA , Behera Samarendra 
Published: January 2025

Abstract

A study was conducted to find out the biodiversity of macrophytes and their seasonal variation in the beautiful perennial reservoir during October, 2021 to September, 2022. The reservoir drains the excess water through canal in Damodar River which is passing through northern side of the reservoir. During the study period, a total of 10 species of macrophytes were recorded. The diversity index i.e. Margalef Richness Index (d=0.62) and Pielou’s evenness Index (J’=0.9) was highest in summer months, Shannon and Weiner Index (H’=1.57) and Simpson’s Index (λ’=0.77) was highest in monsoon months respectively. Lowest value for all the Index was observed in rainy season. The aquatic macrophytes are naturally occurring, well adopted to the environment and thus play an important role to reduce the water pollution by absorbing the nutrients of water. The surrounding villagers use the reservoir as a source of water for drinking, washing, bathing, household activity as well as important source of income generation by harvesting of fish and also open defecation on reservoir bank resulting anthropogenic source of pollution and enrichment of nutrients for macrophytes, gradually degrading the quality of reservoir. The spatial distribution of macrophytes as well as annual and seasonal variability is essential for planning, development and management of the reservoir.
Global disease burden of non-Hodgkin lymphoma in adolescents and young adults aged 15 to 39 from 1990 to 2021
Authors: Tang Bin , Zhu Yuqing , Xiao Qifan , Kang Mande 
Published: January 2025

Abstract

Background
Non-Hodgkin lymphoma (NHL) can occur at any age but is more common in middle-aged and older adults. Although the incidence of NHL is lower in adolescents and young adults (AYAs) aged 15–39 years, certain types have seen an increase in incidence in recent years. However, specific data remains incomplete, with regional and population-based differences.
Methods
This study, based on the latest global burden of disease data from 2021, provided a comprehensive analysis of the incidence, mortality, disability-adjusted life years (DALYs), and associated risk factors for NHL in AYAs aged 15–39 years, considering multiple dimensions such as age, gender, social-demographic index (SDI), and nationality.
Results
From 1990 to 2021, the global incidence of NHL in AYAs aged 15–39 years increased from 1.75 per 100,000 in 1990 to 2.15 per 100,000 in 2021. However, both mortality and DALYs showed a declining trend. Specifically, mortality decreased from 0.79 per 100,000 in 1990 to 0.71 per 100,000 in 2021, while DALYs dropped from 49.75 per 100,000 in 1990 to 44.57 per 100,000 in 2021. The incidence of NHL was significantly higher in high SDI regions compared to low SDI regions. The primary risk factor associated with NHL mortality and DALYs was a high body mass index (BMI)
Conclusion
Over the past 32 years, the global disease burden of NHL in AYAs aged 15–39 years has increased, with significant differences in burden levels across regions with varying SDI.
Thorite: An Oddity in Phase Stability Amongst the Zircon-Structured Orthosilicates at High Pressures
Authors: Strzelecki Andrew C. , Baker Jason L. , Chariton Stella , Zhao Xiaodong , Prakapenka Vitali , Bollinger David , Ahmed Sohan , Fortner Jeffrey , Szenknect Stephanie , Mesbah Adel , McCloy John S. , Yoo Choong-Shik , Ewing Rodney C. , Dacheux Nicolas , Xu Hongwu , Guo Xiaofeng 
Published: January 2025

Abstract
Synthetic thorite and huttonite, two polymorphs of ThSiO4, were investigated by a combination of in situ high-pressure synchrotron X-ray powder diffraction and in situ high pressure Raman spectroscopy. The average onset pressure of the thorite-to-huttonite transition was determined to be 6.6 ± 0.2 GPa, using both techniques. The bulk moduli of thorite and huttonite were determined to be 139(9) and 246(11) GPa, respectively, by fitting their unit-cell volume data to a second order Birch-Murnaghan equation of state (EOS). Based on its bulk modulus, thorite is the most compressible zircon-structured orthosilicate, as it has the largest unit cell volume among tetravalent metal orthosilicates. The pressure derivatives of the vibrational modes of thorite were found to be consistent with those previously reported for other orthosilicates (e.g., zircon, hafnon, stetindite, and coffinite), while having the smallest Grüneisen parameter. A new P-T phase diagram for ThSiO4 is proposed, where the boundary of the thorite → huttonite transition is: P(T) = (7.8 ± 0.9 GPa) − (0.006 ± 0.002 GPa/K)T. Based on the new P-T phase diagram, we further estimated the enthalpy of formation of huttonite, ΔHf,ox, to be 0.6 ± 6.0 kJ/mol, suggesting its metastability and rare locality in nature.
Late diagnosis of spinal muscular atrophy, primary symptoms of the disease according to the patient registry of the SMA Families Foundation
Authors: Artemyeva S. В. , Papina Yu. О. , Germanenko O. Yu. 
Published: January 2025

Introduction. Spinal muscular atrophy 5q is a common childhood disease in the practice of a pediatrician and pediatric neurologist. Despite the introduction of neonatal screening in the Russian Federation since 2023, there is a cohort of patients who were not included in neonatal screening and the relevance of knowledge of the clinical symptoms of SMA remains.Aim. To study the reasons for delayed diagnosis of spinal muscular atrophy in the Russian Federation.Materials and methods. We analyzed the data of the registry of 1452 patients with SMA: the time of delay in diagnosis from the onset of the first clinical symptoms, identified the first clinical symptoms and analyzed erroneous primary diagnoses that increased the time of correct diagnosis. Patients were divided into two groups: group 1 of patients (1170) born before 2019, the second group of patients (274) born from 2019 to 2023. An analysis of the medical records of 330 patients with SMA observed at the Veltischev Scientific Research Institute was conducted in order to analyze the clinical symptoms of SMA that were underestimated by primary care physicians and led to a delay in correct diagnosis.Results. In the 1st group of patients, 146 patients with SMA type 1, 531 SMA type 2, 493 – SMA type 3, 8 – SMA type 4 were registered. The delay in diagnosis was 4 months, 2 years 4 months, 5 years 2 months, 11 years, respectively. In the 2nd group of patients, 176 patients with SMA type 1, 81 – SMA type 2, 17 – SMA type 3 were registered. The delay in diagnosis was SMA1 – 2 months, SMA2 – 6 months, SMA3 – 6 months. Since 2019, there has been a significant decrease in the delay in diagnosis, especially for SMA types 2 and 3 up to 6 months. The primary and most significant clinical symptoms for patients with different types of SMA are determined.Conclusions. Underestimating of clinical symptoms of spinal muscular atrophy leads to late molecular genetic diagnosis of the disease. The identified initial clinical signs of spinal muscular atrophy of different types will allow primary care physicians to suspect the disease in time and refer patients for confirmatory molecular genetic diagnostics.
Pengaruh Harga, Lokasi, Keamanan, Kenyamanan, Dan Fasilitas Terhadap Minat Sewa
Authors: Agriansyah Ahmad 
Published: January 2025

As a city with the highest number of university students in East Java, Malang has the most users of Mamikos, a platform for room-rent seekers. However, anxiety still hampers the application’s users and partners, mostly caused by price, location, security, comfort, and facility. The objective of this research is to identify the effects of price, location, security, comfort, and facility on the intention of university students in Malang City to rent rooms via the platform. The respondents of this quantitative explanatory research were selected using purposive sampling technique, resulting in 400 people. The validity, reliability and classical assumption tests were conducted in the Statistical Package for the Social Science (SPSS), while the data analysis was performed using multiple linear regression. The hypothesis testing was held to assess the model’s feasibility and the partial effects. Based on the hypothesis testing, this study finds that price, location, security, comfort, and facility partially have some effects on the intention to rent rooms via Mamikos.

Abstrak
Kota Malang sebagai kota dengan jumlah mahasiswa terbanyak se-Provinsi Jawa Timur mengakibatkan tingginya jumlah pengguna platfrom Mamikos. Namun, masih banyak keresahan yang dialami oleh pengguna dan mitra dalam menggunakan platform Mamikos terutama pada aspek harga, lokasi, keamanan, kenyamanan dan fasilitas. Penelitian ini bertujuan untuk mengetahui pengaruh harga, lokasi, keamanan, kenyamanan dan fasilitas terhadap minat sewa melalui platfrom Mamikos (studi pada mahasiswa di Kota Malang). Jenis penelitian ini adalah explanatory research dengan metode kuantitatif. Penelitian ini menggunakan sampel sebanyak 400 responden dan pengambilan sampel menggunakan teknik purposive sampling. Penelitian ini menggunakan Statistical Package for the Social Sciences (SPSS) untuk melakukan uji validitas, uji reliabilitas dan uji asumsi klasik. Teknik analisis data menggunakan uji regresi linear berganda. Uji hipotesis dilakukan untuk menguji hipotesis kelayakan model dan pengaruh secara parsial. Berdasarkan hasil pengujian hipotesis diperoleh data variabel harga, lokasi, keamanan, kenyamanan dan fasilitas masing-masing berpengaruh terhadap minat sewa indekos pada platfrom Mamikos.
Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial
Authors: Zhang Dandan , Fu MuLi , Zhang Jianzhong , Li Yuxuan , Chen Li , Chen Yong-Jun , Zhong Zhefeng , Zhang Yin-Ping 
Published: January 2025

Background
During infectious disease outbreaks such as the COVID-19 pandemic, nurses are crucial in patient care and public health safety; however, they face challenges such as inadequate training and high stress in isolation wards. Virtual reality (VR) technology offers innovative training solutions to enhance nurses’ clinical skills and preparedness. However, extensive studies on its effectiveness in isolation ward environments are still limited.

Objective
This study aims to develop a nonimmersive VR (NIVR) simulation training program for isolation wards and further validate its feasibility and training effectiveness in aiding nurses in adapting to isolation ward settings.

Methods
This study was a prospective, parallel, open-label, randomized controlled trial. A total of 90 nurses from 3 hospitals in China were randomly assigned to either the control or intervention group, with 45 (50%) individuals in each group. Both groups received training on isolation ward layout and nursing procedures. The control group underwent a 4-hour conventional training session consisting of 2 hours of face-to-face lectures and 2 hours of ward visits. The intervention group received a 4-hour NIVR simulation training session. Subsequently, both groups completed approximately 4 hours of emergency drills and assessments.

Results
After the intervention, there were no significant differences in theoretical test or performance assessment scores between the 2 groups (t88=–0.30, P=.75; Cohen d=–0.06; z score=0.00, P>.99), using a 2-tailed t test. However, the intervention group completed 6 tasks faster than the control group (t88=5.10, P<.001; Cohen d=1.08), with an average reduction of about 3 minutes (control group: mean 43.91, SD 2.99 min; intervention group: mean 40.77, SD 2.85 min). Notably, they completed task 3 (patient reception inward) and task 6 (exiting the isolation area) significantly quicker (t88=3.22, P=.002; Cohen d=0.68; t88=3.03, P=.003; Cohen d=0.64, respectively), with no significant differences for the other tasks.

Conclusions
This study highlights the potential of NIVR simulation training for nurses working in isolation wards. Although NIVR simulation training does not significantly surpass traditional methods in imparting theoretical knowledge, it does reduce task completion time for specific activities. Its capacity for safe, repetitive practice and realistic scenario simulation makes NIVR a valuable tool in medical education. Further research and optimization of VR simulation training programs are recommended to enhance nurses’ practical skills and pandemic preparedness.

Trial Registration
Chinese Clinical Trial Registry ChiCTR240083155; https://www.chictr.org.cn/hvshowproject.html?id=250356&v=1.0
A produção científica sobre a regulação de medicamentos sem registro no Brasil, nos Estados Unidos e na Europa
Authors: Dos Santos Teles Cardoso Amanda , Alves Costa Ediná 
Published: January 2025

Introduction: The use of unregistered drugs indicates a shift in the regulatory paradigm for innovative medicines by shortening access to drugs that are still in the experimental phase, which also increases uncertainties regarding the risks associated with their use. Objective: to identify the characteristics of scientific publications on the regulation of unregistered drugs in Brazil, the United States, and Europe. Method: This is a descriptive, quantitative study involving bibliometric analysis. A total of 58 studies were selected based on the descriptors and eligibility criteria from the SciELO, Portal Capes, and Web of Science databases. Absolute and relative frequency analyses, as well as averages of the categories listed in the analysis plan, and keyword profiles using VOSviewer® were performed. Results: Researchers’ interest in this topic has been growing since 2016. Academic production was concentrated in the United States, with original articles having low methodological rigor, and focused on medical journals. Some studies declared conflicts of interest with the pharmaceutical industry. The central themes were “aspects of the regulatory framework for expanded access/compassionate use” and “ethics in the use of unregistered drugs,” with the main keywords being: expanded access, efficacy, safety, Covid-19, risk, emergency authorization, and real-world data. Conclusions: The regulation of unregistered drugs deserves further exploration through high-quality studies in the field of Public Health, particularly in countries of the global south, with research that focuses on building elements of individual and collective health protection in the regulation of unregistered drugs.
Modifying the DC Servo Motor Observed by Particle Swarm Optimization Techniques
Authors: Saxena Arti , Panse Vishal R , Asyhari Ardian , Umam Rofiqul , Michalska-Domańska Marta , Dixit Aparna 
Published: January 2025

The PID controller's optimized tuning improves the control system's functionality. This work presented the tuning of the PID/FOPID controller by the conventional Ziegler-Nichols (ZN) method and the Particle Swarm Optimization (PSO) algorithm. The PID controller is the most popular in the industry because it is simple to implement, has good computing ability, and provides a robust system. These methods are implemented on the DC servomotor system to optimize the transient responses like rise time (𝑡𝑟), settling time (𝑡𝑠), and peak overshoot (𝑀𝑝) to get a better result. The PID controller tuned by the conventional ZN method gives a longer settling time, a longer rise time, and a higher peak overshoot. The PSO algorithm is utilized to overcome the significant overshoot and considerable settling time obtained in the conventional Ziegler-Nichols method. Analyzing and comparing the MATLAB simulation results, it is observed that PSO algorithms provide a better-optimized response over the ZN method with FOPID controller in respect of less rise time (𝑡𝑟 =0.0392 sec.), less settling time (𝑡𝑠=0.0605 sec.) and peak overshoot (𝑀𝑝=1.92%). The results obtained by the proposed controller provide better reliability and better response.