bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Literature Review of Esports Integrity
Authors: Riedl Erika , Verschuuren Pim 
Published: January 2025

Abstract

While esports activities have been constantly growing over the past two decades, academic literature on esports has emerged in several fields, including in the appraisal of various integrity dimensions of the games in recent years. The authors conducted a first systematic review of this literature on esports integrity in order to synthetize existing knowledge and establish the potential academic research gaps in this area. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology has been used, as well as the eSAFE conceptual framework. 57 scientific sources have been included in the analysis, which outlines a relatively laconic and fragmented literature. However, various issues related to the prevalence of integrity risks, regulatory measures and policies or perceptions from the fans and participants attract an increasing interest. Key avenues for further research are the specificities of integrity risks and management within different games, as well as sectorial-wide dimensions, such as regulation (including public law and private disciplinary frameworks) and policies design and enforcement. Finally, we discuss practical implications of our research.
Triple coinfections of Brucella abortus, scrub typhus, and S. typhi in the subtropical region of Nepal: A rare case report
Authors: Basyal Santosh , yadav Dipendra prasad , Acharya Neeraj , Budhathoki Roshika , parajuli Rahul , Bhattarai Shardul 
Published: January 2025

Abstract

Background
Brucella is a zoonotic bacterial infection that requires antibiotic treatment. Four of the six traditional diseases cause human zoonoses: B. melitensis, B. abortus, B. suis, and B. canis. B. melitensis causes the majority of cases worldwide, but B. abortus is often misdiagnosed. The lack of clear symptoms often leads to the underdiagnosis of scrub typhus, another endemic disease in Nepal. In Nepal, typhoid, dengue fever, and scrub typhus spread during the monsoon and post monsoon seasons, often coinfecting each other.
Case presentation:
A 35-year-old female patient with fever, fatigue, and myalgia presented to Damak Hospital in Jhapa, Nepal, with no history of close contact with animals. We admitted her due to her fever, fatigue, and myalgia, and initial reports revealed a decrease in her hemoglobin and platelets. Routine urinalysis and stools were normal, but the patient tested positive for the S. typhi O antigen. Enzyme-linked immunosorbent assay (ELISA) tests revealed positive results for scrub typhus and Brucella abortus antigens.
Conclusion:
This study identified triple coinfection via enzyme-linked immunosorbent assay (ELISA) and Widal testing in rural areas, with the aim of early detection in endemic regions such as Nepal and South Asia.
GEGVIC: A workflow to analyze Gene Expression, Genetic Variations and Immune cell Composition of tumor samples using Next Generation Sequencing data
Authors: Arqués Oriol , Faidherbe Solen , Bassaganyas Laia 
Published: January 2025

Abstract

Background.
The application of next-generation sequencing techniques for genome and transcriptome profiling is to build the main source of data for cancer research. Hundreds of bioinformatic pipelines have been developed to handle the data generated by these technologies, but their use often requires specialized expertise in data wrangling and analysis that limit many biomedical researchers. Providing easy-to-use, yet comprehensive and integrative open-source tools is essential to help wet-lab and clinical scientists feel more autonomous in performing common omics data analysis in cancer research.
Results.
Here, we present GEGVIC, an R tool to easily perform a set of frequently used analyses in cancer research, including differential gene expression, genomic mutations exploration and immune cell deconvolution using minimally processed human/mouse genomic and transcriptomic sequencing data. GEGVIC is designed as a modular pipeline that combines a variety of widely used available methods distributed in three principal modules (Gene Expression, Genomic Variation and Immune Composition), which run independently and include several visualization tools.
Conclusions.
In summary, GEGVIC provides a simple, powerful and highly flexible workflow for researchers to process and interpret tumor transcriptomic and genomic data while decreasing or eliminating coding burden and facilitating efficiency for inexperienced bioinformatics users. GEGVIC R package instructions and source code are published on Github (https://github.com/oriolarques/GEGVIC).
Mapping the Landscape of Digital Health Intervention Strategies: 25-Year Synthesis
Authors: Liu Shiyu , Ma Jingru , Sun Meichen , Zhang Chao , Gao Yujing , Xu Jinghong 
Published: January 2025

Background
Digital health interventions have emerged as promising tools to promote health behavior change and improve health outcomes. However, a comprehensive synthesis of strategies contributing to these interventions is lacking.

Objective
This study aims to (1) identify and categorize the strategies used in digital health interventions over the past 25 years; (2) explore the differences and changes in these strategies across time periods, countries, populations, delivery methods, and senders; and (3) serve as a valuable reference for future researchers and practitioners to improve the effectiveness of digital health interventions.

Methods
This study followed a systematic review approach, complemented by close reading and text coding. A comprehensive search for published English academic papers from PubMed, Web of Science, and Scopus was conducted. The search employed a combination of digital health and intervention-related terms, along with database-specific subject headings and filters. The time span covered 25 years, from January 1, 1999, to March 10, 2024. Sample papers were selected based on study design, intervention details, and strategies. The strategies were identified and categorized based on the principles of Behavior Change Techniques and Behavior Strategies.

Results
A total of 885 papers involving 954,847 participants met the eligibility criteria. We identified 173 unique strategies used in digital health interventions, categorized into 19 themes. The 3 most frequently used strategies in the sample papers were “guide” (n=492, 55.6%), “monitor” (n=490, 55.4%), and “communication” (n=392, 44.3%). The number of strategies employed in each paper ranged from 1 to 32. Most interventions targeted clients (n=844, 95.4%) and were carried out in hospitals (n=268, 30.3%). High-income countries demonstrated a substantially higher number and diversity of identified strategies than low- and middle-income countries, and the number of studies targeting the public (n=647, 73.1%) far exceeded those focusing on vulnerable groups (n=238, 26.9%).

Conclusions
Digital health interventions and strategies have undergone considerable development over the past 25 years. They have evolved from simple approaches to sophisticated, personalized techniques and are trending toward multifaceted interventions, leveraging advanced technologies for real-time monitoring and feedback. Future studies should focus on rigorous evaluations, long-term effectiveness, and tailored approaches for diverse populations, and more attention should be given to vulnerable groups.
Tiempos de migrar: la educación de la niñez migrante haitiana y centroamericana en la frontera noroeste de México
Authors: Vargas-Valle Eunice D. , López Castro Eder Orlando 
Published: January 2025

El objetivo de este artículo es analizar la situación de la educación de la niñez migrante internacional proveniente de Haití y de Centroamérica que residía en Tijuana, México, en 2022, la mayoría en espera de refugio en Estados Unidos. Se usa metodología mixta que integra el análisis de una encuesta dirigida a migrantes de estos orígenes con 6 o más meses en Tijuana, así como entrevistas a migrantes de estos orígenes y a actores clave. Como parte de los resultados se encuentra una muy baja inserción escolar - incluso para aquellos migrantes que se ubican fuera de albergues-, y se identifican un conjunto de barreras motivacionales, económicas, culturales y sociales para la inserción escolar de estos migrantes, así como las acciones estatales y de organizaciones civiles para la escolarización y el desarrollo de aprendizajes de estas poblaciones.
Validación de un instrumento para evaluar la difusión, divulgación y uso de productos comunicativos científicos para la enseñanza-aprendizaje en educación superior
Authors: Leon Duarte Gustavo Adolfo , Contreras Cázares Carlos René , Meneses Jurado Erika Carolina 
Published: January 2025

Con una tradición de al menos seis décadas, en Norteamérica la difusión y la divulgación científica ha sido vista como una responsabilidad directa de la academia y de la ciencia, pese a que son escasos los modelos que aspiran a medir su impacto. Este texto expone el diseño y validación de un instrumento para evaluar la práctica académica de comunicación científica en el que convergen los factores de difusión, divulgación y práctica docente en el uso de productos comunicativos científicos para la enseñanza-aprendizaje. El instrumento se integró a cuatro escalas y 33 indicadores sobre una muestra de 235 docentes investigadores de 16 universidades ubicadas en México, Estados Unidos de América y Canadá, principalmente. Los resultados de las pruebas de las correlaciones mostraron una validez convergente con coeficientes altos y significativos. Para estudios subsecuentes, se propone un modelo ampliado con la finalidad de que sirva como base para diversificar diseños y alcances de investigación
Broadband HMSIW antenna using a demi hexagonal ring slot for X-band application
Authors: Astuti Dian Widi , Muslim Muslim , Umaisaroh Umaisaroh , A Majid Huda , Alam Syah 
Published: January 2025

Microstrip antennas offer several advantages, including small size, easy fabrication, controllable polarity and radiation patterns, and easy integration with other components. These qualities make microstrip antennas more reliable than other antenna types. However, they also have limitations, such as lower radiation efficiency and narrow bandwidth, primarily due to the thin substrate thickness. Substrate integrated waveguide (SIW) is a type of microstrip antenna. SIW antennas come in two forms: one with a rectangular shape, typically designed as a slot, and the other in the form of a horn. However, SIW slot antennas face challenges with narrow impedance bandwidth due to the thin substrate, unlike conventional bulky hollow waveguides. The half-mode substrate integrated waveguide (HMSIW) slot antenna, which is a 50% miniaturized version of the SIW slot antenna, also suffers from reduced fractional bandwidth, resulting from the miniaturization and the thin substrate. This paper focuses on enhancing the bandwidth of HMSIW antennas by incorporating a demi-hexagonal ring slot. The broadband impedance bandwidth simulation (27.36%) is achieved through triple resonance frequencies to address the issue of narrow impedance bandwidth. Both the simulation results and measurements show consistency, with the measured impedance bandwidth ranging from 8.91 to 12.62 GHz (34.46%), demonstrating at least triple resonance frequencies.
An algorithm for identifying causes of reoperations after orthopedic fracture surgery in health administrative data: a diagnostic accuracy study using the Danish National Patient Register
Authors: Jensen Signe S , Rønnegaard Anders B , Gundtoft Per H , Kold Søren , Viberg Bjarke 
Published: January 2025

Background and purpose: Disease- or procedure-specific registers offer valuable information but are costly and often inaccurate regarding outcome measures. Alternatively, automatically collected data from administrative systems could be a solution, given their high completeness. Our primary aim was to validate a method for identifying secondary surgical procedures (reoperations) in the Danish National Patient Register (DNPR) within the first year following primary fracture surgery. The secondary aim was to evaluate the accuracy of the diagnosis and procedure codes used to determine the causes of these reoperations. Finally, we developed algorithms to enhance precision in identifying the reasons for reoperations.Methods: In a national cohort of 11,551 patients with primary fracture surgery, reoperations were identified through subsequent surgical procedure codes in the DNPR. Each patient record was reviewed to confirm the reoperations and causes. To improve accuracy, a stepwise algorithm was developed for each cause.Results: We identified 2,347 possible reoperations; 2,212 were validated as true reoperations by review of patient record, i.e., a 94% positive predictive value (PPV). However, the coding for the causes of these reoperations was inaccurate. Our algorithm identified major reoperations with a sensitivity/PPV of 89/77%, minor reoperations 99%/89%, infections 77/85%, nonunion 82/56%, early re-osteosynthesis 90/75%, and secondary arthroplasties 95/87%.Conclusion: While the overall reported reoperations in the DNPR had a high PPV, the predefined diagnosis and procedure codes alone were not sufficient to accurately determine the causes of these reoperations. An algorithm was developed for this purpose, yielding acceptable results for all causes except nonunion.
5-year migration and inducible displacement of the uncemented LCS and ATTUNE rotating platform knee systems: a secondary report of a randomized controlled RSA trial
Authors: Puijk Raymond , Koster Lennard A , Pijls Bart G C W , Singh Jiwanjot , Schager Marjolein , Kaptein Bart L , Nolte Peter A 
Published: January 2025

Background and purpose: Early migration of the uncemented cruciate-sacrificing rotating platform ATTUNE and Low Contact Stress (LCS) tibial components was classified as at-risk for aseptic loosening rates exceeding 6.5% at 15 years based on recent fixation-specific migration thresholds. In this secondary report of a randomized controlled trial (RCT) we aimed to evaluate whether the 5-year migration, inducible displacement, and the clinical outcome of the ATTUNE components were comparable to those of the LCS.Methods: Patients from the initial 2-year radiostereometric analysis (RSA) RCT were recruited for a 5-year follow-up. At 5 years, participants underwent 2 supine and 1 loaded RSA examination, clinical assessments, and questionnaires. Migration was analyzed using maximum total point motion (MTPM), translations, and rotations, focusing on 5-year migration, continuous migration (> 0.10 mm/year), and inducible displacement. Revisions, along with clinical and functional outcomes, were also evaluated.Results: At 5 years, 24 ATTUNE and 24 LCS implants were analyzed. The mean MTPM was similar for tibial components (ATTUNE 1.13mm [confidence interval (CI) 0.94–1.33]; LCS 1.24 mm [CI 1.05–1.46]) but significantly lower for the ATTUNE femoral component (1.14 mm [CI 0.92–1.39]) than LCS 1.87 mm [CI 1.57–2.21]). 2-to-5-year migration rates were comparable, but 11 ATTUNE and 7 LCS exceeded 0.10 mm MTPM/year, indicating a higher risk of loosening. Inducible displacement was similar, although 1 patient with a tibial ATTUNE showed excessive displacement (3.34 mm MTPM) with focal osteolysis but no symptoms. 1 revision 10 days post-surgery was performed for an ATTUNE insert spinout, resolved with an isolated insert exchange. Clinical and functional outcomes were comparable.Conclusion: At the 5-year follow-up, ATTUNE tibial components showed similar migration, while the femoral component migrated significantly less than the LCS, which mainly occurred during the first 2 years. 2-to-5-year migration rates, inducible displacement, and clinical and functional outcomes were comparable. These findings suggest a comparable long-term risk of aseptic loosening between the uncemented ATTUNE and LCS knee systems.
Vascularized fibular grafting following tumor resection demonstrates acceptable long-term outcomes in Denmark: a national retrospective cohort study
Authors: Nielsen Christian Lind , Dybdal Daniel Thor Halberg , Vester-Glowinski Peter , Hjalgrim Lisa Lyngsie , Wendtland Pernille Edslev , Kiil Birgitte Jul , Bendtsen Michael Melchior , Petersen Michael Mørk , Baad-Hansen Thomas 
Published: January 2025

Background and purpose: Vascularized fibular grafting following tumor resection is an essential treatment option in limb salvage surgery. We aimed to evaluate: (I) bone healing, (II) complications and reoperations, (III) limb salvage, and (IV) survival.Methods: We present a retrospective evaluation of a national cohort comprising 27 patients. The indications were 13 cases of Ewing sarcoma, 12 cases of osteosarcoma, and 2 cases of giant cell tumor. The median age at surgery was 16 years (interquartile range [IQR] 10–18), and the median follow-up was 82 months (IQR 32–101). Patients were analyzed overall, as well as in subgroups based on tumor location (upper versus lower extremity) and pathology (osteosarcoma versus Ewing sarcoma).Results: The primary rate of graft union was 63%, and after secondary procedures the overall rate of graft union was 67%, with a median time to union of 13 months (IQR 9–17). The reoperation rate was 74%, while the limb salvage rate was 93%. The 5-year overall survival rate was 81% (95% confidence interval [CI] 61–92). Patients with upper extremity tumors were more likely to attain graft union (risk ratio [RR] 5.5, CI 1.3–31.5) and less likely to undergo multiple reoperations (RR 0.3, CI 0.8–0.9) than patients with lower extremity tumors.Conclusion: Vascularized fibular grafting following tumor resection was associated with a graft union rate of 67%, a high frequency of reoperations, a high limb salvage rate (93%), and a 5-year survival rate of 81%.
Peningkatan Pengetahuan tentang Penerapan Frekuensi, Intensitas, Tipe, dan Waktu (FITT) dalam Olahraga Bersepeda pada Klub Gowes Puri Bolon Indah
Authors: Wahyuni Wahyuni , Irawan Joni , Noval Wisda , Ambarsari Dwike Yuni , Wardani Febriyan Shofika , Wijaya Estu , Nuralim Pentira , Sakinah  , Pratiwi Devie Kirana , Nasuka Muhamad 
Published: January 2025

Latar belakang: Masa pandemi covid 19 membuat sebagian masyarakat menjadi sadar akan pentingnya kesehatan. Kebijakan di rumah saja, pembatasan aktifitas dan interaksi menyebabkan seseorang mengalami kejenuhan, sehingga muncul komunitas-komunitas baru dalam olahraga, salah satunya klub sepeda. Tujuan olahraga adalah untuk meningkatkan kebugaran dan juga imunitas tubuh. Imunitas tubuh akan semakin meningkat dengan adanya olahraga bersepeda yang benar dan diimbangi dengan pola hidup sehat dan pengelolaan stress. Berdasarkan analisis situasi ditemukan bahwa masih banyak dari anggota klub sepeda, salah satunya adalah klub Gowes Puri Bolon Indah yang belum memahami prinsip berolah raga yang benar dan baik untuk kesehatan. Hal tersebut terlihat dari masih banyaknya keluhan berupa mudah lelah saat bersepeda, sakit dan pegal pada otot dan sendi serta kram otot.
Tujuan: Tujuan pengabdian masyarakat ini adalah untuk meningkatkan penetahuan tentang penerapan frekuensi intensitas tipe dan waktu dalam olahraga bersepeda pada klub gowes Puri Bolon Indah
Metode: Kegiatan dilaksanakan selama 9 hari dari tanggal 3 – 11 Januari 2021. Kegiatan diawali dengan diskusi kelompok antara anggota klub dengan tim pengabdian masyarakat, dilanjutkan pengurusan perizinan dan penyuluhan penerapan FITT dalam olahraga bersepeda. Sebelum dan sesudah penyuluhan diberikan test tingkat pengetahuan anggota klub tentang penerapan FITT dalam olahraga bersepeda.
Hasil: Sesudah dilakukan kegiatan selama sembilan hari dengan melakukan pre test dan post test, didapatkan hasil, adanya peningkatan pengetahuan, sikap dan tindakan pada FITT untuk olahraga bersepeda.
Kesimpulan: ada peningkatan pengetahuan tentang FITT dalam olahraga bersepeda pada klub gowes Puri Bolon Indah Colomadu.
On Problems of Establishing State Sovereignty over Antarctic Territories: China’s International Legal Position
Authors: Labin D. K. , Qimeng C. 
Published: January 2025

INTRODUCTION. The Antarctic region is unique in terms of organizing effective management by a large number of states at the same time. For this purpose, the Antarctic Treaty was concluded, which made it possible to prevent the conflicts. Nevertheless, not long ago the concept of territorial division of this region has been actively discussed. China, being one of the most economic rapidly developing states, which implies its interest in strengthening its influence in the Antarctic region, also actively participates in solving the problems related to the legal regulation of the Antarctic region. The purpose of the article is to determine the position of China in relation to the activities in the Antarctic region in general, as well as, establishing state sovereignty over the territories of Antarctica.MATERIALS AND METHODS. The research uses various documents of international legal nature, including international treaties, doctrinal sources and national legislation of foreign countries. The research is carried out with the use of general scientific and special scientific methods. RESEARCH RESULTS. The article provides a comprehensive analysis of the Chinese international legal doctrine concerning the establishment of state sovereignty over the Antarctic territories and makes assumptions on further development of China in the Antarctic region. The main directions of China’s activity, including related to national security and extraction of natural resources, were analyzed. The provisions of the “White Book of China on Antarctica” were also analyzed. In addition, China’s initiatives concerning the establishment of Marine Protected Areas, Specially Managed Areas were examined. The question of whether China has its own Antarctic policy was answered.DISCUSSION AND CONCLUSIONS. The examination of the problems of establishing state sovereignty over the Antarctic territories from the point of view of China allows us to conclude that at the moment China does not have a developed Antarctic policy and is at the stage of its formation. China’s attempts to influence the Antarctic management system began in 2005, when the establishment of the Specially Managed Areas was suggested. Since then, China’s influence has continued to grow. China acted and continues to act in accordance with the Antarctic Treaty System, which indicates that China is not willing to change the system of management of the region to the system of territorial division. At the moment, China’s interests in Antarctica are characterized by an increased focus on scientific research, environmental protection and international cooperation. China’s influence in the region is expected to increase.