bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ivabradine in patients with acute ST-elevation myocardial infarction: a meta-analysis of randomized controlled trials
Authors: Sasmita Bryan Richard , Xie Siyuan , Liu Gang , Zhu Yuansong , Luo Suxin , Huang Bi 
Published: April 2023

Abstract
Background
Elevated resting heart rate (HR) predicts poor outcomes in patients with coronary artery disease. Ivabradine has been recommended as a second-line anti-anginal agent in chronic coronary syndrome, while there are no clear indications for acute ST-elevation myocardial infarction (STEMI).

Results
We systematically searched PubMed, Medline, EMBASE, Clinical Trials.gov, and the Cochrane Central Register of Controlled Trials with search terms Ivabradine and Acute myocardial infarction. There are two study outcomes from this study: therapeutic and safety effects. Therapeutic effects include the efficacy of Ivabradine on HR, all-cause mortality, heart failure incidence, left ventricular function and remodeling. Safety effects include troponin levels and ischemic events (recurrent angina pectoris). A total of 6 RCTs was included and showed that Ivabradine was associated with greater resting HR reduction [MD − 5.40; 95%CI − 8.60, − 2.20], improvement of left ventricular ejection fraction [MD 2.98; 95%CI 0.44, 5.51], and left ventricular end systolic volume [MD − 3.81; 95%CI − 6.88, − 0.75]. However, Ivabradine had no impact on all-cause mortality [OR 0.76; 95%CI 0.35, 1.67], heart failure incidence [OR 0.61; 95%CI 0.21, 1.80], and recurrent angina pectoris [OR 0.71; 95%CI 0.50, 1.00].

Conclusions
Ivabradine is safe and effective for resting HR reduction in patients with STEMI; however, it has no significant influence on mortality. These results suggest that an elevated HR is only a marker of risk but not a modifiable determinant of outcomes in patients who have suffered an acute myocardial infarction.
The Spanish version of the reflective functioning questionnaire: Validity data in the general population and individuals with personality disorders
Authors: Ruiz-Parra Eduardo , Manzano-García Guadalupe , Mediavilla Roberto , Rodríguez-Vega Beatriz , Lahera Guillermo , Moreno-Pérez Ana I. , Torres-Cantero Alberto M. , Rodado-Martínez Juan , Bilbao Amaia , González-Torres Miguel Ángel 
Published: April 2023

Introduction
Mentalization or reflective functioning (RF) is the capacity to interpret oneself or the others in terms of internal mental states. Its failures have been linked to several mental disorders and interventions improving RF have a therapeutic effect. Mentalizing capacity of the parents influences the children’s attachment. The Reflective Functioning Questionnaire (RFQ-8) is a widely used tool for the assessment of RF. No instrument is available to assess general RF in Spanish-speaking samples. The aim of this study is to develop a Spanish version of the RFQ-8 and to evaluate its reliability and validity in the general population and in individuals with personality disorders.

Methods
602 non-clinical and 41 personality disordered participants completed a Spanish translation of the RFQ and a battery of self-reported questionnaires assessing several RF related constructs (alexithymia, perspective taking, identity diffusion and mindfulness), psychopathology (general and specific) and interpersonal problems. Temporal stability was tested in a non-clinical sub-sample of 113 participants.

Results
Exploratory and confirmatory factor analyses suggested a one-factor structure in the Spanish version of the RFQ-8. RFQ-8 understood as a single scale was tested, with low scorings reflecting genuine mentalizing, and high scorings uncertainty. The questionnaire showed good internal consistence in both samples and moderate temporal stability in non-clinical sample. RFQ correlated significantly with identity diffusion, alexithymia, and general psychopathology in both samples; and with mindfulness, perspective taking, and interpersonal problems in clinical sample. Mean values of the scale were significantly higher in the clinical group.

Discussion
This study provides evidence that the Spanish version of the RFQ-8, understood as a single scale, has an adequate reliability and validity assessing failures in reflective functioning (i.e., hypomentalization) in general population and personality disorders.
Healthcare system action on employment as a social determinant of health in people living with HIV: A qualitative study
Authors: Craig-Neil Amy , Ho Julia , Perri Melissa , Gaspar Mark , Hunter Charlotte , Rachlis Beth , Kendall Claire E. , Rueda Sergio , Burchell Ann N. , Pinto Andrew D. 
Published: April 2023

Background
Employment is a key social determinant of health. People living with HIV (PLWH) have higher unemployment rates than the general population. Vocational rehabilitation services have been shown to have significant and positive impact on employment status for PLWH. Understanding whether integrating vocational rehabilitation with health care services is acceptable, from the perspectives of PLWH and their health care providers, is an area that is understudied.

Methods
We conducted a qualitative study and collected data from focus groups and interviews to understand the perspectives of stakeholders regarding the potential for vocational rehabilitation and health care integration. We completed five focus groups with 45 health care providers and one-to-one interviews with 23 PLWHs. Participants were sampled from infectious disease, primary care clinics, and AIDS Service Organizations in Toronto and Ottawa, Canada. Interviews were audio-recorded and transcribed. We conducted a reflexive thematic analysis of the transcripts.

Findings
We found health care providers have little experience assisting patients with employment and PLWH had little experience receiving employment interventions from their health care team. This lack of integration between health care and vocational services was related to uncertainties around drug coverage, physician role and living with an episodic disability. Health care providers thought that there is potential for a larger role for health care clinics in providing employment interventions for PLWH however patients were divided. Some PLWH suggest that health care providers could provide advice on the disclosure of status, work limitations and act as advocates with employers.

Interpretation
Health care providers and some PLWH recognize the importance of integrating health services with vocational services but both groups have little experience with implementing these types of interventions. Thus, there needs to be more study of such interventions, including the processes entailed and outcomes they aim to achieve.
Effectiveness of a blended multidisciplinary intervention for patients with moderate medically unexplained physical symptoms (PARASOL): A cluster randomized clinical trial
Authors: van Westrienen Paula Elisabeth , de Wit Niek , Toonders Suze , Veenhof Cindy , Gerrits Marloes , Pisters Martijn 
Published: April 2023

Introduction
In patients with moderate Medically Unexplained Physical Symptoms (MUPS), interventions focusing on both physical and psychological aspects are recommended. A proactive, blended and integrated physical therapy and mental health nurse intervention (PARASOL) might reduce complaints, stimulate self-management and prevent chronicity.

Objective
To investigate short- and long-term effectiveness of the PARASOL intervention compared to usual care on subjective symptom impact and quality of life in patients with moderate MUPS.

Methods
We conducted a cluster randomized clinical trial. The 12-week intervention integrated face-to-face sessions with the physical therapist and mental health nurse and access to a web-based program consisting of graded activity, exercises and information modules. Primary outcomes were subjective symptom impact, as registered with the adequate relief question, and quality of life. Secondary outcomes were severity of (psychosocial) symptoms, overall current health, physical behaviour, illness perceptions, and self-management skills. Assessment took place at baseline, after three and twelve months.

Results
Compared to usual care (n = 80), the number of patients in the PARASOL intervention (n = 80) that reported adequate short-term relief was higher (31.2% in intervention group vs. 13.7% in control group). On quality of life and secondary outcomes no significant between group differences in short- and long-term were found.

Conclusions
The PARASOL intervention does improve subjective symptom impact of patients with moderate MUPS on short-term. No additional beneficial effects on the other outcomes and the long-term were found.
Validation of the Spanish version of the Pediatric Symptom Checklist (PSC) to identify and assess psychosocial problems among early adolescents in Chile
Authors: Ramírez Saray , Gana Sofía , Godoy María Inés , Valenzuela Daniela , Araya Ricardo , Gaete Jorge 
Published: April 2023

Background
The high prevalence of mental disorders in early adolescents, and their consequences, encourage the need for validated instruments to identify and assess psychosocial problems.

Objectives
i) To evaluate the psychometric properties of the Spanish version of the Pediatric Symptom Checklist (PSC) questionnaires (PSC-Y, 35 items, and PSC-17-Y) and its subscales (Attention, Internalizing and Externalizing subscales), including the assessment of the item structure, concurrent validity, and reliability; and ii) To assess possible associations between bullying experiences, school climate and school membership with psychological problems identified by the PSC questionnaire.

Methods
A cross-sectional study was carried out in 39 schools in Santiago, Chile. The sample consisted of 3,968 adolescents aged between 10 and 11 years. A descriptive analysis of the Pediatric Symptom Checklist was performed along with measures of dimensionality, reliability, and correlations with a validated questionnaire exploring similar constructs, the Strengths and Difficulties Questionnaire. Finally, associations of bullying, school climate, and school membership with the three subscales of the PSC were explored.

Results
Both versions of PSC had problems with item #7 (Act as if driven by motor), which did not load in any of the latent factors. It was removed from later analyses. The three-factor structure of PSC was confirmed. All remaining items had high factor loadings in their corresponded latent factors, and the reliability was high for the total scales (PSC-34-Y, ω = 0.78; PSC-16-Y, ω = 0.94) and the subscales of PSC-16-Y (Attention, ω = 0.77; Internalizing, ω = 0.79; Externalizing, ω = 0.78). The goodness of fit was adequate, and the correlation between PSC subscales and SDQ subscales was high. Victimization and perpetration were associated with all PSC subscales, and higher school climate and stronger school memberships were negatively associated with PSC symptoms.

Conclusions
The current findings seem to demonstrate that the Spanish version of the PSC is a valid and reliable instrument for identifying and assessing psychosocial problems in early adolescents.
A novel aspiration technique to assess cervical remodelling in patients with or without cervical shortening: Sequence of first changes, definition of cut-off values and impact of cervical pessary, stratified for cervical length
Authors: Kyvernitakis Ioannis , Lauer Philien , Malan Marcel , Badir Sabrina , Maul Holger 
Published: April 2023

BackgroundThe therapeutic significance of the cervical pessary has been confirmed by several studies. However, the underlying mechanism by which pessaries reduce the risk of a preterm birth remains elusive. The aim of this study is to investigate the hypothesis whether the application of a cervical pessary may stabilize the ectocervical stiffness in order to achieve a cervical arrest.MethodsThis is a prospective, controlled, non-interventional, post-market, monocentric, longitudinal, cohort study in a tertiary maternity hospital to determine ectocervical stiffness and its changes measured before and after placement of a pessary in singleton pregnancies with cervical shortening in the mid trimester. In order to assess reference values for cervical stiffness, we measured also singleton pregnancies with normal cervical length in the same gestational week spectrum. The cervical stiffness measured with the Pregnolia System as the Cervical Stiffness Index (CSI, in mbar) shall be the primary endpoint, whilst patient delivery data (gestational age, mode of delivery and complications) will be the secondary endpoint. In this pilot study, up to 142 subjects will be enrolled to have a total of 120 subjects (estimated dropout rate of 15%) to complete the study; pessary cohort: 60 (up to 71 recruited), control group: 60 (up to 71 recruited).DiscussionOur hypothesis is that patients with cervical shortening will present with lower CSI values and that pessary placement will be able to stabilize the CSI values through further prevention of cervical remodelling. The measurement of controls with normal cervical length shall serve as a reference.
An integrative review protocol on interventions to improve users’ ability to identify trustworthy online health information
Authors: Mohamed Hind , Salsberg Jon , Kelly Dervla 
Published: April 2023

Background
The epidemiological transition phenomena drive the attention to focus the scope on health literacy as it has an impact on patients’ health outcomes and quality of life.

Aim
This paper aims to explore the implemented interventions for improving users’ ability to identify trustworthy online health information.

Methodology
A comprehensive search of the literature will be conducted on the following electronic bibliographic databases: Ovid Medline, Embase, Cochrane database, Academic search complete and APA psycinfo. Further, manual search of eligible studies reference lists will be carried out to identify other eligible studies. The search strategy will include a combination of three key blocks of terms, namely: (adult OR adults) Or (patient OR patients) OR (layperson OR laypersons) OR (caregiver OR caregivers), (Intervention OR Interventions) OR Educational programs OR (health literacy And curriculum) OR Community outreach OR Interactive workshops OR (Online portal OR Patient Portals), and information seeking behavior OR consumer health information OR online information OR social media OR access to information. The results of these categories will then be combined using the AND connector. Two independent reviewers will screen and assess data quality. Disagreements will be resolved by consensus. Due to the anticipated methodological pluralism of the potentially eligible studies, a narrative synthesis of the findings on interventions aimed at improving users’ ability to identify trustworthy online information will be provided according to the pre-identified thematic areas. Furthermore, a narrative synthesis of the reported barriers and facilitators for applying these interventions by end users.

Expected results and impact
Given that the focus of our review findings is on understanding the breadth and depth of the global research into interventions to improve users’ ability to identify trustworthy online health information. The findings will be of great value to inform future innovative approaches to promote identification of trustable online sources for young people worldwide.
Outfitting the Conservative Civil Rights Movement: Rehearsed White Victimhood and the MAGA Hat
Authors: Neville-Shepard Meredith , Neville-Shepard Ryan 
Published: April 2023

Abstract
This essay contends that the red MAGA hat in the modern conservative movement plays off Donald Trump's populist construction of his supporters as victims by creating opportunities for the performance of what we call “rehearsed victimhood.” As an enactment of vulnerability that allows individuals in historically powerful positions to claim marginalized status by manifesting material evidence of their subjugation, we argue that rehearsed victimhood relies on weaponized polysemy to bait critics, the cooptation of civil rights rhetoric, and acts of humiliation and violent self-sacrifice. We illustrate the performance of rehearsed victimhood through a close reading of media coverage of numerous incidents where Trump supporters claimed discrimination after being attacked, fired, or ridiculed for wearing a MAGA hat.
Coronary Stent Off-Wire Dislodgement: Case Report of a Rare Complication
Authors: Lu Meng-Ying , Wang Kuang-Te 
Published: April 2023

Abstract
Although several techniques have been reported for managing an on-wire dislodged stent in the coronary artery, very few reports have focused on the much rarer complication of an off-wire dislodged stent. In a 73-year-old man who experienced an off-wire dislodged coronary stent, the proximal elongated segment was lodged in the left main coronary artery, and the distal segment was floating in the aorta like a wind sock. After a failed attempt at retrieval using a gooseneck microsnare, the dislodged stent was successfully removed using a 3-loop vascular snare via the left radial artery. There was no obvious vascular injury. This novel technique for removing a partially floating dislodged stent was successful after conventional retrieval techniques failed.
The impact of chronic stress on intracellular redox balance: A systems level analysis
Authors: Geddie Hannah , Cairns Megan , Smith Logan , van Wyk Minette , Beselaar Leandrie , Truter Nina , Rautenbach Fanie , Marnewick Jeanine L. , Joseph Danzil E. , Essop M. Faadiel 
Published: April 2023

AbstractChronic psychosocial stress is implicated in the onset and progression of noncommunicable diseases, and mechanisms underlying this relationship include alterations to the intracellular redox state. However, such changes are often investigated in isolation, with few studies adopting a system level approach. Here, male Wistar rats were exposed to 9.5 weeks of chronic unpredictable mild stress and redox status assays were subsequently performed on cardiac, hepatic, and brain tissues versus matched controls. The stressed rats displayed an anxious phenotype, with lowered plasma corticosterone levels (p = 0.04 vs. Controls) and higher plasma epinephrine concentrations (p = 0.03 vs. Controls). Our findings showed organ‐specific redox profiles, with stressed rats displaying increased myocardial lipid peroxidation (p = 0.04 vs. Controls) in the presence of elevated nonenzymatic antioxidant capacity (p = 0.04 vs. Controls). Conversely, hepatic tissues of stressed rats exhibited lowered nonenzymatic antioxidant capacity (p < 0.001 vs. Controls) together with increased superoxide dismutase (SOD) activity (p = 0.05 vs. Controls). The brain displayed region‐specific antioxidant perturbations, with increased SOD activity (p = 0.01 vs. Controls) in the prefrontal cortex of the stressed rats. These findings reveal distinct stress‐related organ‐specific vulnerability to redox perturbations and may provide novel insights into putative therapeutic targets.
Lessons Learned from Digital-Only Experiences
Authors: Degkwitz Andreas 
Published: April 2023

Abstract
Digitisation includes technical systems that communicate with each other but can only communicate the characters for which input and output interfaces are available. That is a fraction of what human communication is all about. The resulting lack of contact bothers us and we find it inadequate. In times of Covid-19 we have learned that the longer the phases of exclusively digitally executed workflows and processes last, the more we realise that we lack activities that do not require digital technology, as it was a matter of course before Corona. This leads us to ask what it means when we become avatars or robots of ourselves. The following demonstrations of an exclusively digitally organised summer festival and a fully digitised library can give us insights into the purely digital perspective.
Ausflug in eine ferne nahe Welt: Forschungsalltag 2040
Authors: Frick Claudia , Heller Lambert 
Published: April 2023

Zusammenfassung
Anhand der jungen Forscherin Elena werfen wir einen mit Absicht dystopischen Blick in die fiktive Zukunft wissenschaftlichen Arbeitens, und zwar in jene Zukunft im Jahr 2040, in der wir alle Warnzeichen und fragwürdigen bis negativen Entwicklungen seit 2020 ignoriert und der Bequemlichkeit und dem Druck nachgegeben haben. Willkommen im Forschungsalltag 2040, der nicht nur durch Plattformökonomie, sondern auch durch eine fragmentierte Wissenschaftslandschaft aufgrund eines Wirtschaftskrieges geprägt ist. Anhand einzelner kurzer Szenen aus einem ihrer normalen Arbeitstage erhalten wir Einblick in Elenas subjektives Erleben dieser Zukunft. Am Ende wirft sie einen Blick zurück und fragt sich, wie es so weit kommen konnte.
Wagnis Dissens. Kritische (Selbst-)Befragungen zur programmatischen Demokratieförderung schwedischer Bibliotheken
Authors: Wischmann Antje 
Published: April 2023

Zusammenfassung
Der Beitrag bezieht die aktuelle schwedische Bibliotheksdebatte auf die europaweit entfachte Diskussion zur Verteidigung und Stärkung der Demokratie. Im Zuge der Kritik an Habermas’ Öffentlichkeitskonzept, dessen frühe Version von homogenisierenden Vorstellungen geleitet war, wird nun versucht, demokratische Prozeduren und Repräsentationsweisen ausgehend von divergierenden Überzeugungen (Dissens) und länger anhaltenden Konflikten neu zu fassen. Der demokratiesichernde Auftrag – nicht nur – der schwedischen Bibliotheken zeichnet sich dadurch aus, in Krisen- und Konfliktlagen Informationen und Orientierungswissen bereitzustellen, ein sicherer öffentlicher Raum zu sein und sowohl das Personal als auch die Anwendenden mit Ressourcen auszustatten, die ihnen jederzeit ermöglichen, gesprächsbereit und handlungsfähig zu bleiben.
FDM-Sprint: Enlightening Research Data Management
Authors: Mersmann Jana , Grunwald-Eckhardt Laura , Dallinga Ann-Christin 
Published: April 2023

Zusammenfassung
In diesem Beitrag werden, inspiriert von praxiserprobten Book- und Paper-Sprints, unterschiedliche Optionen für ein interaktives Forschungsdatenmanagement als Vermittlungsansatz beleuchtet. An einem Schulungskonzept wird anhand unterschiedlicher Einstiege beispielhaft demonstriert, wie u. a. die aufgrund starker fachspezifischer Ausprägungen im Forschungsdatenmanagement unabdingbare Fachexpertise eingesetzt werden kann. Die mit diesem Konzept einhergehende, an vielen Stellen notwendige Flexibilität birgt vielfältige Herausforderungen, weshalb entsprechende Lösungsansätze eingehend thematisiert werden.
„Someone has to organize it“ – Widerstand
linked open
Authors: Bemme Jens , Erlinger Christian 
Published: April 2023

Zusammenfassung
Das Wikiversum mit all seinen Portalen und den Prinzipien der Offenheit und Vernetztheit bildet eine wesentliche Säule unserer gegenwärtigen Wissensversorgung. Damit dieser Strom an Wissen aufrecht bleibt und neue Vernetzungen, Ergebnisse und Erkenntnisse aus diesen Ressourcen entstehen können, braucht es Beitragende und Pflegende für diese Datenbestände. Mit den Wikimedians in Residence existiert ein Konzept, das Brücken zwischen institutioneller Informationsversorgung und freier gemeinschaftsbasierter Arbeit herzustellen vermag. Erschließung und Datenbereitstellung außerhalb gewohnt institutioneller und strenger Arbeitsumgebungen heißt einmal mehr, Widerstand und Einsatz zu erhöhen – und für freien, dauerhaften und einfachen Zugang zu Wissen und qualitätsvolle Erschließung zu kämpfen.