bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apical papillary muscle displacement is a prevalent feature and a phenotypic precursor of apical hypertrophic cardiomyopathy
Authors: Filomena Domenico , Vandenberk Bert , Dresselaers Tom , Willems Rik , Van Cleemput Johan , Olivotto Iacopo , Robyns Tomas , Bogaert Jan 
Published: April 2023

Abstract

Aims
Papillary muscle (PM) abnormalities are considered part of the phenotypic spectrum of hypertrophic cardiomyopathy (HCM). The aim of this study was to evaluate the presence and frequency of PM displacement in different HCM phenotypes.

Methods and results
We retrospectively analysed cardiovascular magnetic resonance (CMR) findings in 156 patients (25% females, median age 57 years). Patients were divided into three groups: septal hypertrophy (Sep-HCM, n = 70, 45%), mixed hypertrophy (Mixed-HCM, n = 48, 31%), and apical hypertrophy (Ap-HCM, n = 38, 24%). Fifty-five healthy subjects were enrolled as controls. Apical PM displacement was observed in 13% of controls and 55% of patients, which was most common in the Ap-HCM group, followed by the Mixed-HCM and Sep-HCM groups (respectively: inferomedial PM 92 vs. 65 vs. 13%, P &lt; 0.001; anterolateral PM 61 vs. 40 vs. 9%, P &lt; 0.001). Significant differences in PM displacement were found when comparing healthy controls with patients with Ap- and Mixed-HCM subtypes but not when comparing them with patients with the Sep-HCM subtype. T-wave inversion in the inferior and lateral leads was more frequent in patients with Ap-HCM (100 and 65%, respectively) when compared with Mixed-HCM (89 and 29%, respectively) and Sep-HCM (57 and 17%, respectively; P &lt; 0.001 for both). Eight patients with Ap-HCM had prior CMR examinations because of T-wave inversion [median interval 7 (3–8) years], and in the first CMR study, none showed apical hypertrophy [median apical wall thickness 8 (7–9) mm], while all of them presented with apical PM displacement.

Conclusion
Apical PM displacement is part of the phenotypic Ap-HCM spectrum and may precede the development of hypertrophy. These observations suggest a potential pathogenetic, mechanical link between apical PM displacement and Ap-HCM.
Left atrial reservoir strain predicts ischaemic stroke after coronary artery bypass grafting independent of postoperative atrial fibrillation
Authors: Vyff Frederikke , Johansen Niklas Dyrby , Olsen Flemming J , Duus Lisa S , Lindberg Søren , Fritz-Hansen Thomas , Pedersen Sune , Iversen Allan , Galatius Søren , Møgelvang Rasmus , Biering-Sørensen Tor 
Published: April 2023

Abstract

Aims
Measures of left atrial (LA) function are known to predict both ischaemic stroke and atrial fibrillation in specific patient groups. The aim of this study was to investigate the value of LA reservoir strain for predicting ischaemic stroke in patients undergoing coronary artery bypass grafting (CABG) and investigate whether the presence of postoperative atrial fibrillation (POAF) modified this relationship.

Methods and results
Patients undergoing isolated CABG were included. The primary endpoint was ischaemic stroke. The association between LA reservoir strain and ischaemic stroke was investigated in uni- and multivariable Cox proportional hazards regression models including adjustment for POAF.
We included 542 patients (mean age 67.3±8.9 years, 16.4% female). During a median follow-up period of 3.9 years, 21 patients (3.9%) experienced an ischaemic stroke. In total, 96 patients (17.7%) developed POAF during the index hospitalization. In a multivariable-adjusted Cox proportional hazards regression model, LA reservoir strain was significantly associated with the development of ischaemic stroke [HR (hazard ratio) 1.09 (95% CI 1.02–1.17) per 1% decrease, P = 0.011]. The presence of POAF did not modify this association (p for interaction = 0.07). The predictive value of the LA reservoir strain persisted in multiple sensitivity analyses including restricting the analysis to patients with normal left atrial volumes (LAV&lt;34 ml/m2), patients without POAF, patients without prior stroke, and when excluding patients who developed atrial fibrillation at any time during follow-up.

Conclusion
LA reservoir strain was independently associated with ischaemic stroke in CABG patients. The predictive value of LA reservoir strain was unaffected by the presence of POAF. Prospective studies are warranted to validate the potential usefulness of LA reservoir strain to predict postoperative ischaemic stroke in the setting of CABG.
The Dark Side of Transparency: Mission Variety and Industry Equilibrium in Decentralised Public Good Provision
Authors: Aldashev Gani , Jaimovich Esteban , Verdier Thierry 
Published: April 2023

Abstract
We study the implications of transparency policies on decentralised public good provision by the non-profit sector. We present a model where imperfect monitoring of the use of funds interacts with the competitive structure of the non-profit sector under alternative informational regimes. Increasing transparency regarding the use of funds may have ambiguous effects on total public good provision and on donors’ welfare. On the one hand, transparency encourages all non-profit firms to engage more actively in curbing fund diversion. On the other hand, it tilts the playing field against non-profits facing higher monitoring costs, pressing them to give up on their missions. This effect on the extensive margin implies that transparency policies lead to a reduction in the diversity of social missions addressed by the non-profit sector. We show that the negative impact of transparency on social mission variety and on donors’ welfare is highest for intermediate levels of asymmetry in monitoring costs.
Evaluating semi- and nonparametric regression algorithms in quantifying stem taper and volume with alternative test data selection strategies
Authors: Yang Sheng-I , Burkhart Harold E , Seki Mehmet 
Published: April 2023

Abstract
Accurately quantifying stem taper is essential to predict diameter at any given height along the stem and to estimate tree volume for various sections of the stem. With increased computing power, semi- and nonparamatric methods have been proposed as alternative approaches for modelling tree taper. The main objective of this study was to assess the accuracy of stem taper predicted for four pine and four hardwood species by semi- and nonparametric models. Specifically, generalized additive models (GAM), random forests (RF) and regression-enhanced random forests (RERF) were compared with two widely-used parametric models: variable-exponent function (VAR) and segmented polynomial regression model (SEG). Test datasets selected from four different data splitting methods were used to examine the prediction accuracy of the models. Results showed that all examined models can be used to quantify stem taper and volume for all species when prediction is limited to be within the range of tree sizes used in model building. The nonparametric RF algorithm generally produced higher bias and lower precision than the semiparametric (GAM and RERF) and parametric models (VAR and SEG). For all species, GAM, VAR and SEG provided more robust predictions of stem taper than RF and RERF algorithms, especially when small or large trees were withheld for model testing. The data splitting strategies used in this work provide an efficient ‘stress test’ to evaluate model performance when collecting an independent test dataset is not feasible. The findings of this work provide additional insights for forest practitioners and resource managers to select appropriate methods in stem taper modelling.
Canopy and surface fuel estimations using RPAS and ground-based point clouds
Authors: Arkin Jeremy , Coops Nicholas C , Daniels Lori D , Plowright Andrew 
Published: April 2023

Abstract
Forest management activities intended to reduce wildfire risk rely on accurate characterizations of the amount and arrangement of canopy and surface fuels. Metrics that describe these fuels are typically estimated with various systems that transform plot-level field data into metrics that can be used within fire behaviour models. Remote sensing data have long been used to estimate these metrics across large spatial scales, but more advanced, high-density point clouds have the potential to estimate these metrics with higher accuracy. This study collected LiDAR and digital aerial photogrammetric (DAP) point clouds from a remotely piloted aerial system (RPAS), as well as mobile laser scanning (MLS) point clouds from a mobile ground-based system, and compared their ability to estimate fuel metrics. This involved the extraction of predictor variables from each point cloud, of which small subsets were used to estimate various fuel metrics. These included six overstory canopy metrics (stand height, canopy cover, tree density, canopy fuel load, canopy bulk density and canopy base height), three diameter at breast height (DBH)–related metrics (stand density index, basal area and quadratic mean diameter) and three surface fuel metrics (total woody debris (TWD), coarse woody debris (CWD) and fine woody debris (FWD)). Overall, canopy metrics were estimated most accurately by the RPAS LiDAR models, although none of the point clouds were able to accurately estimate DBH-related metrics. For the other six canopy metrics, RPAS LiDAR models had an average R2 value of 0.70; DAP – 0.63 and MLS – 0.63. CWD (&gt;7 cm) and TWD loads were estimated most accurately by the MLS models (average R2 values – 0.70), followed by the RPAS LiDAR – 0.38 and DAP – 0.13. None of these models were able to accurately estimate FWD loads (≤7 cm in diameter), with the three types of point clouds having a maximum R2 value of 0.08. Overall, this research shows the relative ability of three types of high-density point clouds to estimate metrics relevant for fire behaviour modeling.
Population Aging and Heat Exposure in the 21st Century: Which U.S. Regions Are at Greatest Risk and Why?
Authors: Carr Deborah , Falchetta Giacomo , Sue Wing Ian 
Published: April 2023

Abstract

Background and Objectives
The co-occurring trends of population aging and climate change mean that rising numbers of U.S. older adults are at risk of intensifying heat exposure. We estimate county-level variations in older populations’ heat exposure in the early (1995–2014) and mid (2050) 21st century. We identify the extent to which rising exposures are attributable to climate change versus population aging.

Research Design and Methods
We estimate older adults’ heat exposure in 3,109 counties in the 48 contiguous U.S. states. Analyses use NASA NEX Global Daily Downscaled Product (NEX-GDDP-CMIP6) climate data and county-level projections for the size and distribution of the U.S. age 69+ population.

Results
Population aging and rising temperatures are documented throughout the United States, with particular “hotspots” in the Deep South, Florida, and parts of the rural Midwest. Increases in heat exposure by 2050 will be especially steep in historically colder regions with large older populations in New England, the upper Midwest, and rural Mountain regions. Rising temperatures are driving exposure in historically colder regions, whereas population aging is driving exposure in historically warm southern regions.

Discussion and Implications
Interventions to address the impacts of temperature extremes on older adult well-being should consider the geographic distribution and drivers of this exposure. In historically cooler areas where climate change is driving exposures, investments in warning systems may be productive, whereas investments in health care and social services infrastructures are essential in historically hot regions where exposures are driven by population aging.
Religious masculinities in William of Newburgh’s Historia rerum Anglicarum
Authors: Perisanidi Maroula 
Published: April 2023

Abstract
William’s revenant stories, far from being oddities, fit well within the Historia rerum Anglicarum and can be read as reformist models of masculine behaviour. They present the reader with negative examples, such as clerics who acted in inappropriate ways and got their rightful punishment, as well as positive examples of men who not only stayed faithful to the precepts of the church but bolstered their masculinity by doing so. Reading the revenant stories within this framework allows us to see how religious men adopted and adapted secular masculine ideals, shows us the value of focusing on the intersection of gender and religious status, reveals the different means through which gendered messages spread, and acts as a reminder that although one group may have been the target of regulations, all men were affected by them.
Effectiveness and Safety of Vortioxetine for the Treatment of Major Depressive Disorder in the Real World: A Systematic Review and Meta-Analysis
Authors: Li Zejun , Liu Shouhuan , Wu Qiuxia , Li Jing , Yang Qian , Wang Xin , Peng Pu , Wang Qianjin , Liu Yueheng , Li Manyun , Hao Yuzhu , Xu Huixue , He Li , Wang Yunfei , Chen Shubao , Liu Tieqiao 
Published: April 2023

AbstractIntroductionMajor depressive disorder (MDD) is a highly prevalent and burdensome condition. This study aims to evaluate the effectiveness, tolerability, and safety of vortioxetine in treating MDD based on real-world data.MethodsA systematic search of 8 electronic databases was performed from inception until October 2022 to identify real-world studies, excluding randomized controlled trials. We conducted subgroup, meta-regression, sensitivity analyses, publication bias, and quality assessments using the random-effects model. The effects were summarized by rates or standardized mean difference (SMD) with 95% confidence interval (CI).ResultsOf the 870 records identified, 11 studies (3139 participants) and 10 case reports or series were eligible for inclusion. Vortioxetine significantly relieved depression symptoms as assessed by both patients (SMD = 2.25, 95% CI = 1.60−2.89) and physicians (SMD = 3.73, 95% CI = 2.78−4.69). Cognitive function (SMD =1.86, 95% CI = 1.11−2.62) and functional disability (SMD =1.71, 95% CI = 1.14−2.29) were similarly markedly improved. Subgroup and meta-regression analyses showed that geographic location and medication regimen (whether combined with other antidepressants) were crucial factors influencing effectiveness (in terms of depression severity and cognitive function), potentially contributing to significant heterogeneity. The estimated response and remission rates were 66.4% (95% CI = 51.2%−81.5%) and 58.0% (95% CI = 48.9%−67.1%), respectively. Vortioxetine was well tolerated, with a pooled dropout rate of 3.5% (95% CI = 1.8%−5.8%), and the most common adverse event was nausea, with an estimated rate of 8.9% (95% CI = 3.8%−15.8%).LimitationsThe study has some limitations, including significant heterogeneity and limited evidence for some outcomes.ConclusionsVortioxetine is effective, well tolerated, and safe for treating MDD in clinical practice, with significant improvements observed in depressive severity, cognitive function, and functioning. Future studies should directly compare vortioxetine with other antidepressants in real-world settings to further evaluate its clinical utility.
Efficacy of a bacterial 6-phytase supplemented beyond traditional dose levels on jejunal mucosa-associated microbiota, ileal nutrient digestibility, bone parameters, and intestinal health, and growth performance of nursery pigs
Authors: Moita Vitor Hugo C , Kim Sung Woo 
Published: April 2023

Abstract
This study aimed to determine the efficacy of a bacterial 6-phytase (Buttiauxella spp.) supplemented beyond traditional dose levels based on jejunal mucosa-associated microbiota, apparent ileal digestibility (AID), intestinal health and bone parameters, and growth performance of nursery pigs. Seventy-two weaned pigs (36 barrows and 36 gilts at 21 d of age with 5.8 ± 0.5 kg BW) were allotted to six treatments based on randomized complete block design with sex and initial BW as blocks and fed in three dietary phases (phase 1 for 14 d, phase 2 for 10 d, and phase 3 for 14 d). The treatments included a negative control (NC) diet without phytase formulated meeting nutrient requirements by NRC and the other five treatments were deficient in calcium (Ca) and phosphorus (P) by 0.12% with increasing levels of a bacterial 6-phytase (0, 500, 1,000, 2,000, and 5,000 FTU/kg feed). Titanium dioxide (0.4%) was added to phase 3 diets as an indigestible marker to measure AID of nutrients. On day 45, all pigs were euthanized to collect ileal digesta to measure AID, the third metacarpus to measure bone parameters, and jejunal mucosa to evaluate intestinal health and microbiota. Data were analyzed using the MIXED procedure for polynomial contrasts and the NLMIXED procedure for broken line analysis using the SAS 9.4. Broken line analysis demonstrated that 948 FTU/kg feed increased (P &lt; 0.05) the ADG and the bone P content. Increasing phytase supplementation increased (linear, P &lt; 0.05) AID of CP, bone P, and ash content. Increasing phytase supplementation reduced (P &lt; 0.05) the fecal score during phases 2 and 3. Broken line analysis demonstrated that 1,889 FTU/kg feed increased (P &lt; 0.05) bone breaking strength. Increasing phytase supplementation (PC vs. Phy) increased (P &lt; 0.05) AID of ether extract (EE) and P. The supplementation of phytase at 2,000 FTU/kg feed tended (P = 0.087) to reduce the relative abundance of Prevotellaceae. In conclusion, the supplementation of a bacterial 6-phytase beyond traditional dose levels improved bone breaking strength, bone ash, and P content, AID of CP, EE, and P, and growth performance of nursery pigs with reduced relative abundance of Bacteroidetes specifically Prevotellaceae in the jejunal mucosa. Supplementation of a bacterial 6-phytase between 1,000 and 2,000 FTU/kg feed provided benefits associated with growth performance and bone parameters of nursery pigs.
Potential therapeutic role for pigment epithelium-derived factor in post-menopausal breast cancer bone metastasis
Authors: Brook Naomi , Dharmarajan Arun , Chan Arlene , Dass Crispin R 
Published: April 2023

Abstract

Objectives
This review discusses key oestrogens associated with the circulating pre- and post-menopausal milieu and how they may impact intratumoral oestrogen levels and breast cancer (BC) metastasis. It also identifies critical steps in BC metastasis to bone from the viewpoint of pigment epithelium-derived factor (PEDF) function, and discusses the role of several associated pro-metastatic biomarkers in BC bone metastasis.

Key findings
PEDF is regulated by oestrogen in a number of oestrogen-sensitive tissues. Changes in circulating oestrogen levels associated with menopause may enhance the growth of BC bone metastases, leading to the establishment of a pre-metastatic niche. The establishment of such a pre-metastatic niche is driven by several key mediators, with pro-osteoclastic and pro-metastatic function which are upregulated by BC cells. These mediators appear to be regulated by oestrogen, as well as differentially affected by menopausal status. PEDF interacts with several pro-metastatic, pro-osteoclastic biomarkers, including C-X-C motif chemokine receptor 4 (CXCR4) and nuclear factor kappa B (NFκB) in BC bone metastasis.

Conclusion
Mediators such as CXCR4 and MT1-MMP underpin the ability of PEDF to function as an antimetastatic in other cancers such as osteosarcoma, highlighting the possibility that this serpin could be used as a therapeutic against BC metastasis in future.
Measurement error models for spatial network lattice data: Analysis of car crashes in Leeds
Authors: Gilardi Andrea , Borgoni Riccardo , Presicce Luca , Mateu Jorge 
Published: April 2023

AbstractRoad casualties represent an alarming concern for modern societies. During the last years, several authors proposed sophisticated approaches to help authorities implement new policies. These models were usually developed considering a set of socio-economic variables and ignoring the measurement error, which can bias the statistical inference. This paper presents a Bayesian model to analyse car crash occurrences at the network-lattice level, taking into account measurement error in the spatial covariate. The suggested methodology is exemplified by considering the collisions in the road network of Leeds (UK) during 2011–2019. Traffic volumes are approximated using an extensive set of counts obtained from mobile devices and the estimates are adjusted using a spatial measurement error correction.
Role of hydraulic traits in stomatal regulation of transpiration under different vapour pressure deficits across five Mediterranean tree crops
Authors: Hernandez-Santana Virginia , Rodriguez-Dominguez Celia M , Sebastian-Azcona Jaime , Perez-Romero Luis Felipe , Diaz-Espejo Antonio 
Published: April 2023

Abstract
The differential stomatal regulation of transpiration among plant species in response to water deficit is not fully understood, although several hydraulic traits have been reported to influence it. This knowledge gap is partly due to a lack of direct and concomitant experimental data on transpiration, stomatal conductance, and hydraulic traits. We measured sap flux density (Js), stomatal conductance (gs), and different hydraulic traits in five crop species. Our aim was to contribute to establishing the causal relationship between water consumption and its regulation using a hydraulic trait-based approach. The results showed that the species-specific regulation of Js by gs was overall coordinated with the functional hydraulic traits analysed. Particularly relevant was the negative and significant relationship found between the Huber value (Hv) and its functional analogue ratio between maximum Js and gs (Jsmax/gsmax) which can be understood as a compensation to maintain the hydraulic supply to the leaves. The Hv was also significantly related to the slope of the relationship between gs and Js response to vapour pressure deficit and explained most of its variability, adding up to evidence recognizing Hv as a major trait in plant water relations. Thus, a hydraulic basis for regulation of tree water use should be considered.
Chemical cartography with LAMOST and Gaia reveal azimuthal and spiral structure in the Galactic disc
Authors: Hawkins Keith 
Published: April 2023

ABSTRACT
Chemical Cartography, or mapping, of our Galaxy has the potential to fully transform our view of its structure and formation. In this work, we use chemical cartography to explore the metallicity distribution of OBAF-type disc stars from the LAMOST survey and a complementary sample of disc giant stars from Gaia DR3. We use these samples to constrain the radial and vertical metallicity gradients across the Galactic disc. We also explore whether there are detectable azimuthal variations in the metallicity distribution on top of the radial gradient. For the OBAF-type star sample from LAMOST, we find a radial metallicity gradient of Δ[Fe/H]/ΔR ∼−0.078 ± 0.001 dex kpc−1 in the plane of the disc and a vertical metallicity gradient of Δ[Fe/H]/ΔZ ∼−0.15 ± 0.01 dex kpc−1 in the solar neighbourhood. The radial gradient becomes shallower with increasing vertical height, while the vertical gradient becomes shallower with increasing Galactocentric radius, consistent with other studies. We also find detectable spatially dependent azimuthal variations on top of the radial metallicity gradient at the level of ∼0.10 dex. Interestingly, the azimuthal variations appear be close to the Galactic spiral arms in one data set (Gaia DR3) but not the other (LAMOST). These results suggest that there is azimuthal structure in the Galactic metallicity distribution and that in some cases it is co-located with spiral arms.