bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding public support for COVID-19 pandemic mitigation measures over time: Does it wear out?
Authors: De Wit John B. F. , de Ridder Denise T. D. , van den Boom Wijnand , Kroese Floor M. , van den Putte Bas , Stok F. Marijn , Leurs Mariken , de Bruin Marijn 
Published: March 2023

BackgroundCOVID-19 mitigation measures intend to protect public health, but their adverse psychological, social, and economic effects weaken public support. Less favorable trade-offs may especially weaken support for more restrictive measures. Support for mitigation measures may also differ between population subgroups who experience different benefits and costs, and decrease over time, a phenomenon termed “pandemic fatigue.”MethodsWe examined self-reported support for COVID-19 mitigation measures in the Netherlands over 12 consecutives waves of data collection between April 2020 and May 2021 in an open population cohort study. Participants were recruited through community panels of the 25 regional public health services, and through links to the online surveys advertised on social media. The 54,010 unique participants in the cohort study on average participated in 4 waves of data collection. Most participants were female (65%), middle-aged [57% (40–69 years)], highly educated (57%), not living alone (84%), residing in an urban area (60%), and born in the Netherlands (95%).ResultsCOVID-19 mitigation measures implemented in the Netherlands remained generally well-supported over time [all scores &gt;3 on 5-point scale ranging 1 (low)−5 (high)]. During the whole period studied, support was highest for personal hygiene measures, quarantine and wearing face masks, high but somewhat lower for not shaking hands, testing and self-isolation, and restricting social contacts, and lowest for limiting visitors at home, and not traveling abroad. Women and higher educated people were more supportive of some mitigation measures than men and lower educated people. Older people were more supportive of more restrictive measures than younger people, and support for more socially restrictive measures decreased most over time in higher educated people or in younger people.ConclusionsThis study found no support for pandemic fatigue in terms of a gradual decline in support for all mitigation measures in the first year of the pandemic. Rather, findings suggest that support for mitigation measures reflects a balancing of benefits and cost, which may change over time, and differ between measures and population subgroups.
Perceived research burden of a novel therapeutic intervention: A study of transcranial magnetic stimulation for smoking cessation
Authors: Shevorykin Alina , Carl Ellen , Liskiewicz Amylynn , Hanlon Colleen A. , Bickel Warren K. , Mahoney Martin C. , Vantucci Darian , Bensch Lindsey , Thorner Hannah , Marion Matthew , Sheffer Christine E. 
Published: March 2023

BackgroundTranslating repetitive transcranial magnetic stimulation (rTMS) into evidence-based clinical applications relies on research volunteers with different perspectives on the burden of study participation. Additionally, clinical applications of rTMS require multiple visits over weeks or months, the impact of research burden is an important component for these studies and translation of these findings to clinical practice. High frequency rTMS has significant potential to be developed as an evidence-based treatment for smoking cessation, however, the optimal rTMS dosing strategies have yet to be determined. Participant burden is an important component of determining optimal dosing strategy for rTMS as a treatment for long-term smoking cessation.MethodsIn this double-blinded, sham-controlled, randomized design, the effects of treatment duration, intensity, and active/sham assignment of rTMS on research burden were examined.ResultsOverall level of perceived research burden was low. Experienced burden (M = 26.50) was significantly lower than anticipated burden (M = 34.12). Research burden did not vary by race or income.ConclusionsOverall research burden was relatively low. Contrary to our hypotheses, we found little evidence of added significant burden for increasing the duration or intensity of rTMS, and we found little evidence for differences in research burden by race or income.Clinical Trial Registrationidentifier NCT03865472.
Nomogram based on TNM stage to predict the prognosis of thymic epithelial tumors (TETs) patients undergoing extended thymectomy
Authors: Li Yanzhi , Tang Zhanpeng , Zhu Xirui , Tian Hui 
Published: March 2023

BackgroundThymomas and thymic carcinoma are thymic epithelial tumors (TETs) of the anterior mediastinum. On the basis of The AJCC 8th Edition of TNM classification, no prognostic prediction model has been established for TETs patients undergoing surgical resection. In this study, based on data from Qilu Hospital of Shandong University, we identified prognostic factors and developed a nomogram to predict the prognosis for TETs patients undergoing extended thymectomy.MethodsPatients with TETs who underwent thymectomy between 2010 and 2020 were consecutively enrolled. An analysis of multivariate Cox regression and stepwise regression using the Akaike information criterion (AIC) was conducted to identify prognostic factors, and a nomogram for TETs was derived from the results of these analyses. The model was validated internally with the Kaplan-Meier curves, ROC curves and calibration curves.ResultsThere were 350 patients with TETs enrolled in the study, and they were divided into a training group (245,0.7) and a validation group (105,0.3). Age, histological type, tumor size, myasthenia gravis, and TNM stage were independent prognostic factors for CSS. The Kaplan-Meier curves showed a significant difference between high nomorisk group and low nomorisk group. A nomogram for CSS was formulated based on the independent prognostic factors and exhibited good discriminative ability as a means of predicting cause-specific mortality, as evidenced by the area under the ROC curves (AUCs) of 3-year, 5-year, and 10-year being 0.946, 0.949, and 0.937, respectively. The calibration curves further revealed excellent consistency between the predicted and actual mortality when using this nomogram.ConclusionThere are several prognostic factors for TETs. Based on TNM stage and other prognostic factors, the nomogram accurately predicted the 3-, 5-, and 10-year mortality rates of patients with TETs in this study. The nomogram could be used to stratify risk and optimize therapy for individual patients.
Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells
Authors: Zhao Ni , Mei Nan , Yi Ye , Wang Hongyan , Wang Yajian , Yao Yu , Li Chunli 
Published: March 2023

Objectives: Pancreatic undifferentiated carcinoma accounts for 2%–7% of pancreatic carcinomas. We aimed to investigate the pathological and genetic characteristics of pancreatic undifferentiated carcinoma with osteoclast-like giant cells and the key points of treatment.Methods: The clinical data and follow-up results of four patients diagnosed with pancreatic undifferentiated carcinoma with osteoclast-like giant cells between May 2015 and May 2020 at the First Affiliated Hospital of Xi’an Jiaotong University were retrospectively analyzed.Results: Chief complaints included “pain and discomfort in the upper abdomen” (2/4), “nausea and vomiting” (1/4) or no symptoms (1/4). Preoperative mildly elevated tumor markers included carcinoembryonic antigen (1/4) and CA19-9 (1/4). The tumors were located in the tail of the pancreas in three patients and the head and neck in one patient. Tumor metastasis was found in pancreatic adipose tissue in two patients and lymph node metastasis in one patient, with microscopic heterogeneous mononuclear cells and scattered osteoclast-like giant cells of various sizes. One patient (1/4) had a mucinous cystic tumor of the pancreas, and two patients (2/4) had adenocarcinoma of the pancreatic duct. Only one patient received postoperative gemcitabine combined with albumin-bound paclitaxel chemotherapy.Conclusion: Currently, treatment guidelines are lacking for PUC-OGC, and prognosis varies markedly. More cases must be reported to clarify its origination. The long-term follow-up of diagnosed patients and genetic mutation testing can also contribute to improving treatment and prognosis of this disease.
Design of Lactococcus lactis Strains Producing Garvicin A and/or Garvicin Q, Either Alone or Together with Nisin A or Nisin Z and High Antimicrobial Activity against Lactococcus garvieae
Authors: Feito Javier , Araújo Carlos , Arbulu Sara , Contente Diogo , Gómez-Sala Beatriz , Díaz-Formoso Lara , Muñoz-Atienza Estefanía , Borrero Juan , Cintas Luis M. , Hernández Pablo E. 
Published: March 2023

Lactococcus garvieae is a main ichthyopathogen in rainbow trout (Oncorhynchus mykiss, Walbaum) farming, although bacteriocinogenic L. garvieae with antimicrobial activity against virulent strains of this species have also been identified. Some of the bacteriocins characterized, such as garvicin A (GarA) and garvicin Q (GarQ), may show potential for the control of the virulent L. garvieae in food, feed and other biotechnological applications. In this study, we report on the design of Lactococcus lactis strains that produce the bacteriocins GarA and/or GarQ, either alone or together with nisin A (NisA) or nisin Z (NisZ). Synthetic genes encoding the signal peptide of the lactococcal protein Usp45 (SPusp45), fused to mature GarA (lgnA) and/or mature GarQ (garQ) and their associated immunity genes (lgnI and garI, respectively), were cloned into the protein expression vectors pMG36c, which contains the P32 constitutive promoter, and pNZ8048c, which contains the inducible PnisA promoter. The transformation of recombinant vectors into lactococcal cells allowed for the production of GarA and/or GarQ by L. lactis subsp. cremoris NZ9000 and their co-production with NisA by Lactococcus lactis subsp. lactis DPC5598 and L. lactis subsp. lactis BB24. The strains L. lactis subsp. cremoris WA2-67 (pJFQI), a producer of GarQ and NisZ, and L. lactis subsp. cremoris WA2-67 (pJFQIAI), a producer of GarA, GarQ and NisZ, demonstrated the highest antimicrobial activity (5.1- to 10.7-fold and 17.3- to 68.2-fold, respectively) against virulent L. garvieae strains.
Vector-Borne Pathogens in Guard Dogs in Ibadan, Nigeria
Authors: Gruenberger Isabella , Liebich Amelie-Victoria , Ajibade Temitayo Olabisi , Obebe Oluwasola Olaiya , Ogbonna Nkiruka Fortunate , Wortha Licha N. , Unterköfler Maria S. , Fuehrer Hans-Peter , Ayinmode Adekunle Bamidele 
Published: March 2023

Canine vector-borne diseases are of great relevance not only regarding animal welfare but also in relation to the One Health concept. Knowledge concerning the most relevant vector-borne pathogens in dogs is scarce and limited to stray dogs in most western African regions, and there is virtually no information about the situation in kept dogs presenting (regularly) to vets. Therefore, the blood samples of 150 owned guard dogs in the Ibadan area—in the southwest of Nigeria—were collected and analyzed for the DNA of Piroplasmida (Babesia, Hepatozoon, Theileria), Filarioidea (e.g., Dirofilaria immitis, Dirofilaria repens), Anaplasmataceae (e.g., Anaplasma, Ehrlichia), Trypanosomatidae (e.g., Leishmania, Trypanosoma), Rickettsia, Bartonella, Borrelia and hemotropic Mycoplasma using molecular methods. Overall, samples from 18 dogs (12%) tested positive for at least one pathogen. Hepatozoon canis (6%) was the most prevalent blood parasite, followed by Babesia rossi (4%). There was a single positive sample each for Babesia vogeli (0.6%) and Anaplasma platys (0.6%). Moreover, one mixed infection with Trypanosoma brucei/evansi and Trypanosoma congolense kilifi was confirmed (0.67%). Generally, the prevalence of vector-borne pathogens in this sample group of owned dogs in southwest Nigeria was lower than in prior studies from the country and in other parts of Africa in total. This leads to the assumption that, firstly, the exact geographical location has a major influence on the incidence of vector-borne diseases, and, secondly, it seems to make a difference if the dogs are owned and, therefore, regularly checked at a veterinary clinic. This study should raise awareness of the importance of routine health check-ups, tick and mosquito prophylaxis, and a well-managed infectious disease control program to prevent vector-borne diseases in canines.
Determinação de parâmetros de qualidade de embalagens metalizadas flexíveis para alimentos
Authors: Soares João Vitor Souza , Prado Wanessa Campos , Da Costa Ana Caroline Pascareli , E Silva Amanda Kezia da Silva , Pereira Carlos Victor Lamarão , Bonatto Jhonny de Araújo , Saraiva Maria das Graças Gomes , Bonatto Eyde Cristianne Saraiva 
Published: March 2023

Os filmes de Polipropileno Biorientado (BOPP) são produtos amplamente consumido para fins de confecção de embalagens flexíveis para alimentos, além disso, possuem resistência mecânica, propriedades de barreira e custo benefício que permitem sua extensa utilização no mercado. Entretanto, a forma de produção, processamento e armazenamento interferem na qualidade do produto. Considerando a importância desse tipo de embalagem, mercado e benefícios que esse tipo de embalagem pode fornecer ao consumidor final, como por exemplo a conservação adequada de certos tipos de alimentos, o objetivo da pesquisa foi analisar a qualidade de embalagens flexíveis de filmes metalizados, através de estudos, diferenciando e verificar os parâmetros de qualidade determinados pela legislação das embalagens flexíveis de BOPP metalizadas comercializadas no ramo alimentício, que foi realizada por meio de analise física. Para tanto, a metodologia utilizada consistiu na caracterização física e na determinação de propriedades gerais e de barreira. Para a caracterização foram realizadas as análises de coeficiente de fricção, resistência à tração, elongação à ruptura e módulo Young. Já para a determinação de propriedades gerais foram realizadas às análises de gramatura, força de delaminação, densidade ótica, testes de espessura e estabilidade dimensional. As propriedades de barreiras foram mensuradas de acordo com a permeabilidade ao Vapor de Água a 90% UR e permeabilidade ao Oxigênio OTR a 23ºC. Nos dias de hoje, as embalagens adquiriram diante de todos, intenso prestígio, não só pelos serviços que prestam, como pela estreita intimidade que com elas mantemos, através de sua presença constante e de sua funcionalidade. Pode-se dizer que a dupla embalagem confere maior barreira a gases e ao vapor d’água e proteção mecânica ao produto. Além disso, as embalagens individuais também podem ser impressas, permitindo que a marca do produto permaneça por mais tempo em contato com o consumidor. Diante do exposto conclui-se ainda que o controle de qualidade é de fundamental importância para a obtenção de um produto bem-acabado, livres de defeitos que possam prejudicar a sua aparência e comercialização.
Caracterização físico-química de iogurte grego probiótico de <em>Lactobacillus acidophilus</em> endocapsulados com calda de cubiu (<em>Solanum sessiliflorum Dunal</em>)
Authors: Soares João Vitor Souza , Da Costa Ana Caroline Pascareli , E Silva Amanda Kezia da Silva , Moura Rodolfo Pessoa de Melo , Pereira Carlos Victor Lamarão , Bonatto Jhonny de Araújo , Saraiva Maria das Graças Gomes , Bonatto Eyde Cristianne Saraiva 
Published: March 2023

Os últimos anos possuíram o foco crescente na saúde e na qualidade de vida, comer alimentos saudáveis e reduzir a ingestão de alimentos ricos em açúcar, sal e gordura. Essa busca pela qualidade de vida tem aumentado a busca por alimentos funcionais, em particular, os probióticos são uma das categorias mais lucrativas no mercado de alimentos funcionais. Nesse contexto, o objetivo do presente trabalho é desenvolver um iogurte probiótico enriquecido e saborizado com fruto não convencional da Amazônia, o cubiu (Solanum sessiliflorum Dunal), visando assim, contribuir para a procura e o crescimento da domesticação de frutos não convencionais dessa região. Para tanto, foi realizada a análises físico-química, viabilidade do microrganismo e vida de prateleira. Foram obtidos, portanto, umidade (64,98%), cinzas (0,61%), carboidratos (25,68%), valor calórico (156Kcal/100g), acidez titulável (0,70%), pH (4,34), lipídeos (3,84%) e proteínas (4,89%). Quanto a viabilidade da adição do microrganismo encapsulado ao iogurte, o estudo mostrou uma boa taxa de sobrevivência (aproximadamente 62%) dos microrganismos após 35 dias. A diferença de tratamento não provocou grandes alterações do ponto de vista físico-químico nos iogurtes produzidos, entretanto, há a necessidade de novos estudos que possam realizar análises mais aprofundadas do produto como análise sensorial, microbiológica e verifiquem a concentração de microrganismos probióticos presentes no produto após a acidificação.
Articulación de la educación superior a través del Programa de Integración Lineal de Estudios Técnicos
Authors: De Jiménez Evelyn Lissette Hernández 
Published: March 2023

La Universidad Don Bosco, “es una Institución apolítica, de inspiración cristiana, no lucrativa creada con carácter permanente que pertenece y patrocina la Institución Salesiana, por fundación y carisma”1, siempre comprometida con el legado de Don Bosco, de formar buenos cristianos y honrados ciudadanos, desarrolla el Proyecto de Integración Lineal de Educación Técnica(PILET) con una modalidad innovadora de educación, que permite articular la enseñanza media técnica con estudios técnicos superiores y de ingeniería. El fin de este proyecto es desarrollar un currículo continuo de los niveles educativos mencionados, y para lograrlo la Universidad Don Bosco (UDB) e Instituciones Salesianas Educativas Medias (ISEM), incorporan programas de estudio que permiten la integración de estudios universitarios con la formación media técnica y desarrollo de competencia en los estudiantes. La Universidad tiene el cometido de autorizar y acreditar los estudios Técnicos Superiores; y las ISEM, implementar los Programas de la UDB dentro de sus instalaciones; y el Ministerio de Educación de El Salvador (MINED) es el ente encargado de garantizar la legalidad del proyecto.
Comparison of predictive growth models for Bacillus cereus in cooked and fried rice during storage
Authors: Rizki Wahyu Mutia , Dewanti-Hariyadi Ratih , Kusumaningrum Harsi Dewantari 
Published: March 2023

This study aimed to develop and compare growth models of Bacillus cereus in cooked and fried rice. A cocktail of B. cereus was inoculated into cooked and fried rice to obtain an initial concentration of ca. 2 log CFU g-1 and stored at 13, 30, 42, and 60oC. The cell concentration of B. cereus during storage were fitted to the primary models of Baranyi, Huang, and modified Gompertz. The maximum specific growth rates (µmax) were fitted to the Ratkowsky model, while the lag phase was fitted using the first-order polynomial model. There was no significant difference (p>0.05) in the µmax and lag phase of B. cereus in cooked rice or fried rice at 13 and 30oC. However, at 42oC the µmax in fried rice was significantly higher (p<0.05) and the lag phase was significantly longer (p<0.05) than those in cooked rice. No growth was observed at 60oC. The Baranyi model showed the best performance in fitting the µmax of B. cereus in cooked and fried rice. The validation study confirmed that the Ratkowsky and the first-order polynomial model could satisfactorily fit the µmax and the lag phase, respectively. Modeling of B. cereus growth in cooked and fried rice can use the primary model of Baranyi fitted to the secondary model of Ratkowsky and first-order polynomial to predict the growth rate and lag phase, respectively. The model suggests that B. cereus grows significantly faster in fried rice at 42oC.
Cuentapropismo juvenil en el Gran Resistencia (Chaco).
Authors: Barbetti Pablo , Sobol Blanca 
Published: March 2023

El artículo propone una caracterización del cuentapropismo de jóvenes que residen en el aglomerado urbano Gran Resistencia (provincia del Chaco), mostrando algunas variaciones en este grupo en dos contextos temporales (prepandemia/pandemia) y comparando las mismas con algunas tendencias a nivel nacional y en la región NEA (nordeste argentino).
Se parte de un diseño metodológico cuantitativo, recurriendo al procesamiento estadístico descriptivo, utilizando como fuente las bases de microdatos individuales de la Encuesta Permanente de Hogares (EPH) perteneciente al Instituto Nacional de Estadística y Censos de la República Argentina (INDEC). Los resultados obtenidos muestran que el cuentapropismo juvenil en el territorio analizado se incrementó en el contexto de pandemia, especialmente en jóvenes de menor edad y nivel educativo. Si bien en este aglomerado urbano se observan tendencias y características similares de esta categoría ocupacional en la población total, el grupo de jóvenes se encuentran en una posición de mayor desventaja en términos de condiciones de trabajo.
Exaerete lepeletieri (Hymenoptera: Apidae: Apini: Euglossina): a new cleptoparasitic bee from Amazonia
Authors: Oliveira Marcio Luiz de , Nemésio André 
Published: March 2023

Exaerete lepeletieri sp. n. (Hymenoptera: Apidae: Apini: Euglossina) is described from Amazonia. Its relationships with the other members of the genus are discussed, including a brief phylogenetic analysis.
Keywords: euglossine, new species, Amazonia.
Pengaruh Kompetensi dan Motivasi terhadap Kinerja Karyawan Pada Kantor Cabang Bri Kota Bekasi
Authors: Puji Salvano Dilla , Ode Labsin Naadu La , Mahendri Hara Teuku 
Published: March 2023

Latar Belakang : Kinerja karyawan merupakan salah satu faktor yang penting dalam meningkatkan keberhasilan suatu perusahaan.
Tujuan : Penelitian ini dilakukan untuk mengetahui pengaruh kompetensi dan motivasi terhadap kinerja karyawan.
Metode : Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Jumlah responden yang diteliti dalam penelitian ini sebanyak 38 orang dengan menggunakan kuesioner sebagai untuk mengumpulkan jawaban. Alat pengambilan keputusan yang digunakan menggunakan analisis regresi linear berganda.
Hasil : Hasil penelitian secara simultan menunjukkan bahwa terdapat pengaruh antara kompetensi dan motivasi terhadap kinerja karyawan, sementara secara parsial menunjukkan bahwa kompetensi tidak berpengaruh terhadap kinerja karyawan, sementara motivasi berpengaruh terhadap kinerja karyawan.
Kesimpulan: Kesimpulan yaitu kompetensi tidak berpengaruh signifikan secara parsial terhadap kinerja karyawan. Hal ini dibuktikan dengan thitung -0.663 > -2.03011 ttabel. Semakin besar nilai kompetensi seorang karyawan tidak berpengaruh terhadap kinerja karyawan.