bluuebunny/crossref_metadata_2025_split huggingface dataset:
Уроки річного протистояння з рф та нові можливості для українського ОПК
Authors: Begma Vitaliy , Shemaev Volodymyr , Radov Denys , Onofriychuk Andriy , Tolok Polina 
Published: May 2023

Мета роботи: експертний аналіз досвіду річного військового протистояння України з рф для оборонної промисловості країн-партнерів та формування практичних рекомендацій щодо реалізації нових можливостей для українського ОПК.
Метод дослідження: у дослідженні використано теоретико-емпіричні методи та метод експертного оцінювання.
Результати дослідження: виявлено тенденції застосування різних типів ОВТ на полі бою, проаналізовано їхній вплив на результат збройового протистояння. Проведено аналіз викликів оборонній промисловості країн ЄС та США щодо забезпечення власних ЗС озброєнням та боєприпасами. Окреслені основні завдання та напрями розвитку оборонної промисловості ЄС та США, а також пов’язані із цим нові можливості для розвитку українського ОПК.
Теоретична цінність дослідження: визначено на системних засадах перелік та зміст специфічних чинників, що характеризують сильні та слабкі сторони продукції оборонної промисловості країн-партнерів, що проявилися в умовах військового протистояння України з РФ, а також можливості та загрози для українського ОПК.
Практична цінність дослідження: Ідентифіковано необхідність економічного забезпечення створення переваги для країни, яка потерпає/може бути піддана нападу агресора (завдяки наявності стратегічних запасів високотехнологічного ОВТ (в т.ч. роботизованих систем) та стратегічних запасів ОВТ того покоління, яке переважно має країна-агресор; широкому застосуванню сучасних інформаційно-телекомунікаційних систем і технологій; створенню широкої міжнародної коаліції країн, що протидіють агресору).
Тип статті: експертно-емпіричний.
Analysis of gut microbiotal diversity in healthy young adults in Sunan County, Gansu Province, China
Authors: Ma Yanqing , Ci Caihong , Zhou Yunsong , Zhang Zilong , Gu Qiaoling , Yang Xiao , An Fulong , An Yan , Lan Yongmei , Zhao Jin 
Published: May 2023

ObjectiveTo examine gut microbiotal diversity in the Han Chinese and Yugur populations of Sunan County, Gansu Province, living in the same environmental conditions, and to analyze possible causes of differences in diversity.MethodsWe selected 28 people, ages 18–45 years old, all of whom were third-generation pure Yugur or Han Chinese from Sunan County. Fresh fecal samples were collected, and total bacterial deoxyribonucleic acid (DNA) was extracted. We performed 16S ribosomal ribonucleic acid (16S rRNA) high-throughput sequencing (HTS) and bioinformatics to study the relationships among between gut microbiota structure, genetics, and dietary habits in Yugur and Han Chinese subjects.ResultsWe found 350 differential operational taxonomic units (OTUs) in Han Chinese and Yugur gut microbiota, proving that gut microbiota differed between the two populations. That were less abundant among Yugurs than Han Chinese were Prevotella_9 and Alloprevotella. That were more abundant among Yugurs than Han Chinese were Anaerostipes and Christensenellaceae_R-7_group. And they were significantly associated with a high-calorie diet In addition. we found differences in predicted gut microbiota structural functions (The main functions were metabolic and genetic information) between the two populations.ConclusionYugur subjects demonstrated differences in gut microbiotal structure from Han Chinese subjects, and this difference influenced by dietary and may be influenced by genetic influences. This finding will provide a fundamental basis for further study of the relationships among gut microbiota, dietary factors, and disease in Sunan County.
Structure and mutation of deoxypodophyllotoxin synthase (DPS) from Podophyllum hexandrum
Authors: Ingold Zoe , Grogan Gideon , Lichman Benjamin R. 
Published: May 2023

Deoxypodophyllotoxin synthase (DPS) is a 2-oxoglutarate (2-OG) dependent non-heme iron (II) dioxygenase that catalyzes the stereoselective ring-closing carbon-carbon bond formation of deoxypodophyllotoxin from the aryllignan (−)-yatein. Deoxypodophyllotoxin is a precursor of topoisomerase II inhibitors, which are on the World Health Organization’s list of essential medicines. Previous work has shown that DPS can accept a range of substrates, indicating it has potential in biocatalytic processes for the formation of diverse polycyclic aryllignans. Recent X-ray structures of the enzyme reveal possible roles for amino acid side chains in substrate recognition and mechanism, although a mutational analysis of DPS was not performed. Here, we present a structure of DPS at an improved resolution of 1.41 Å, in complex with the buffer molecule, Tris, coordinated to the active site iron atom. The structure has informed a mutational analysis of DPS, which suggests a role for a D224-K187 salt bridge in maintaining substrate interactions and a catalytic role for H165, perhaps as the base for the proton abstraction at the final rearomatization step. This work improves our understanding of specific residues’ contributions to the DPS mechanism and can inform future engineering of the enzyme mechanism and substrate scope for the development of a versatile biocatalyst.
The mortality risk after myocardial infraction in migrants compared with natives: a systematic review and meta-analysis
Authors: Zhu Lei , Huang Bao-tao , Chen Mao 
Published: May 2023

Background and ObjectiveThe evidence on the risk of mortality after myocardial infarction (MI) among migrants compared with natives is mixed and limited. The aim of this study is to assess the mortality risk after MI in migrants compared to natives.MethodsThis study protocol is registered with PROSPERO, number CRD42022350876. We searched the Medline and Embase databases, without time and language constraints, for cohort studies that reported the risk of mortality after MI in migrants compared to natives. The migration status is confirmed by country of birth, both migrants and natives are general terms and are not restricted to a particular country or area of destination or origin. Two reviewers separately screened searched studies according to selection criteria, extracted data, and assessed data quality using the Newcastle-Ottawa Scale (NOS) and risk of bias of included studies. Pooled estimates of adjusted and unadjusted mortality after MI were calculated separately using a random-effects model, and subgroup analysis was performed by region of origin and follow-up time.ResultA total of 6 studies were enrolled, including 34,835 migrants and 284,629 natives. The pooled adjusted all-cause mortality of migrants after MI was higher than that of natives (OR, 1.24; 95% CI, 1.10–1.39; I2 = 83.1%), while the the pooled unadjusted mortality of migrants after MI was not significantly different from that of natives (OR, 1.11; 95% CI, 0.69–1.79; I2 = 99.3%). In subgroup analyses, adjusted 5–10 years mortality (3 studies) was higher in the migrant population (OR, 1.27; 95% CI, 1.12–1.45; I2 = 86.8%), while adjusted 30 days (4 studies) and 1–3 years (3 studies) mortality were not significantly different between the two groups. Migrants from Europe (4 studies) (OR, 1.34; 95% CI, 1.16–1.55; I2 = 39%), Africa (3 studies) (OR, 1.50; 95% CI, 01.31–1.72; I2 = 0%), and Latin America (2 studies) (OR, 1.44; 95% CI, 1.30–1.60; I2 = 0%) had significantly higher rates of post-MI mortality than natives, with the exception of migrants of Asian origin (4 studies) (OR, 1.20; 95% CI, 0.99–1.46; I2 = 72.7%).ConclusionsMigrants tend to have lower socioeconomic status, greater psychological stress, less social support, limited access to health care resources, etc., therefore, face a higher risk of mortality after MI in the long term compared to natives. Further research is needed to confirm our conclusions, and more attention should be paid to the cardiovascular health of migrants.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: r CRD42022350876.
The ReInforcement of adherence via self-monitoring app orchestrating biosignals and medication of RivaroXaban in patients with atrial fibrillation and co-morbidities: a study protocol for a randomized controlled trial (RIVOX-AF)
Authors: Yoon Minjae , Park Jin Joo , Hur Taeho , Hua Cam-Hao , Shim Chi Young , Yoo Byung-Su , Cho Hyun-Jai , Lee Seonhwa , Kim Hyue Mee , Kim Ji-Hyun , Lee Sungyoung , Choi Dong-Ju 
Published: May 2023

BackgroundBecause of the short half-life of non-vitamin K antagonist oral anticoagulants (NOACs), consistent drug adherence is crucial to maintain the effect of anticoagulants for stroke prevention in atrial fibrillation (AF). Considering the low adherence to NOACs in practice, we developed a mobile health platform that provides an alert for drug intake, visual confirmation of drug administration, and a list of medication intake history. This study aims to evaluate whether this smartphone app-based intervention will increase drug adherence compared with usual care in patients with AF requiring NOACs in a large population.MethodsThis prospective, randomized, open-label, multicenter trial (RIVOX-AF study) will include a total of 1,042 patients (521 patients in the intervention group and 521 patients in the control group) from 13 tertiary hospitals in South Korea. Patients with AF aged ≥19 years with one or more comorbidities, including heart failure, myocardial infarction, stable angina, hypertension, or diabetes mellitus, will be included in this study. Participants will be randomly assigned to either the intervention group (MEDI-app) or the conventional treatment group in a 1:1 ratio using a web-based randomization service. The intervention group will use a smartphone app that includes an alarm for drug intake, visual confirmation of drug administration through a camera check, and presentation of a list of medication intake history. The primary endpoint is adherence to rivaroxaban by pill count measurements at 12 and 24 weeks. The key secondary endpoints are clinical composite endpoints, including systemic embolic events, stroke, major bleeding requiring transfusion or hospitalization, or death during the 24 weeks of follow-up.DiscussionThis randomized controlled trial will investigate the feasibility and efficacy of smartphone apps and mobile health platforms in improving adherence to NOACs.Trial registrationThe study design has been registered in ClinicalTrial.gov (NCT05557123).
A comparable efficacy and safety between intracardiac echocardiography and transesophageal echocardiography for percutaneous left atrial appendage occlusion
Authors: Zhang Zhi-Yuan , Li Feng , Zhang Jie , Zhang Lei , Liu Huan-Huan , Zhao Ning , Yang Fan , Kong Qi , Zhou Yi-Ting , Qian Ling-Ling , Wang Ru-Xing 
Published: May 2023

BackgroundAccumulated clinical studies utilized intracardiac echocardiography (ICE) to guide percutaneous left atrial appendage occlusion (LAAO). However, its procedural success and safety compared to traditional transesophageal echocardiography (TEE) remained elusive. Therefore, we performed a meta-analysis to compare efficacy and safety of ICE and TEE for LAAO.MethodsWe screened studies from four online databases (including the Cochrane Library, Embase, PubMed, and Web of Science) from their inception to 1 December 2022. We used a random or fixed-effect model to synthesize the clinical outcomes and conducted a subgroup analysis to identify the potential confounding factors.ResultsA total of twenty eligible studies with 3,610 atrial fibrillation (AF) patients (1,564 patients for ICE and 2,046 patients for TEE) were enrolled. Compared with TEE group, there was no significant difference in procedural success rate [risk ratio (RR) = 1.01;P = 0.171], total procedural time [weighted mean difference (WMD) = −5.58;P = 0.292], contrast volume (WMD = −2.61;P = 0.595), fluoroscopic time (WMD = −0.34;P = 0.705;I2 = 82.80%), procedural complications (RR = 0.82;P = 0.261), and long-term adverse events (RR = 0.86;P = 0.329) in the ICE group. Subgroup analysis revealed that ICE group might be associated with the reduction of contrast use and fluoroscopic time in the hypertension proportion &lt;90 subgroup, with lower total procedure time, contrast volume, and the fluoroscopic time in device type subgroup with multi-seal mechanism, and with the lower contrast use in paroxysmal AF (PAF) proportion ≤50 subgroup. Whereas, ICE group might increase the total procedure time in PAF proportion &gt;50 subgroup and contrast use in multi-center subgroup, respectively.ConclusionOur study suggests that ICE may have comparable efficacy and safety compared to TEE for LAAO.
Investigation of hot spring gas components and soil gas fluxes in Arxan Holocene volcanic field, Inner Mongolia, NE China
Authors: Pan Xiaodong , Gu Guohui , Han Di , Bao Baoxiao , Guan Sheng , Song Yujia 
Published: May 2023

The latest research results show that there is a unified magma system and heating channel beneath the Arxan volcanic field, indicating a potential risk of eruption. The Arxan volcanic field features multiple gas emission sites (e.g., Jinjianggou hot springs and Yinjianggou hot springs) and exhibits strong hydrothermal activity. In this study, measurements of the hot spring gas composition and soil CO2 flux in the Arxan Holocene volcanic field were conducted, and the results were combined with previous research results to analyze the degassing characteristics of this region. The results show that the volcanic gases in the Arxan volcanic field are composed of 0.07%–1.09% CO2, 0.33–12 ppm CH4, 1.57–53 ppm H2, 800–30,241 ppm He, and 1.14%–1.86% Ar. The He content in this area is notably higher than that in other dormant volcanoes in China. This difference is possibly caused by U–Th decay in the Mesozoic granodiorite and acidic volcanic rocks in the study area, which can produce substantial radiogenic He. The soil gas concentrations near the Jinjianggou and Yinjianggou hot springs are higher than those of two Holocene volcanoes. The peak CO2 concentration in the soil near the Jinjianggou hot spring can reach 35,161 ppm. The single-site soil microseepage CO2 flux in the Arxan volcanic field is 4.66–107.18 g m−2 d−1, and the estimated annual CO2 emission flux from the volcanic field to the atmosphere is 0.63 × 105 t, which also demonstrates that soil CO2 flux of Arxan volcano is comparable to the soil CO2 emission level of the Iwojima volcano.
Human complement component C3 N-glycome changes in type 1 diabetes complications
Authors: Šoić Dinko , Štambuk Jerko , Tijardović Marko , Keser Toma , Lauc Gordan , Bulum Tomislav , Lovrenčić Marijana Vučić , Rebrina Sandra Vučković , Tomić Martina , Novokmet Mislav , Smirčić-Duvnjak Lea , Gornik Olga 
Published: May 2023

AimChanges in N-glycosylation have been described in numerous diseases and are being considered as biomarkers of ongoing pathological condition. Previous studies demonstrated the interrelation of N-glycosylation and type 1 diabetes (T1D), particularly linking serum N-glycan changes with complications accompanying the disease. Moreover, the role of complement component C3 in diabetic nephropathy and retinopathy has been implicated, and C3 N-glycome was found to be altered in young T1D patients. Therefore, we investigated associations between C3 N-glycan profiles and albuminuria and retinopathy accompanying T1D, as well as glycosylation connection with other known T1D complication risk factors.Research design and methodsComplement component C3 N-glycosylation profiles have been analyzed from 189 serum samples of T1D patients (median age 46) recruited at a Croatian hospital centre. Using our recently developed high-throughput method, relative abundances of all six of the C3 glycopeptides have been determined. Assessment of C3 N-glycome interconnection with T1D complications, hypertension, smoking status, estimated glomerular filtration rate (eGFR), glycaemic control and duration of the disease was done using linear modelling.ResultsSignificant changes of C3 N-glycome in severe albuminuria accompanying type 1 diabetes were observed, as well as in T1D subjects with hypertension. All except one of the C3 glycopeptides proved to be associated with measured HbA1c levels. One of the glycoforms was shown to be changed in non-proliferative T1D retinopathy. Smoking and eGFR showed no effect on C3 N-glycome. Furthermore, C3 N-glycosylation profile was shown to be independent of disease duration.ConclusionThis study empowered the role of C3 N-glycosylation in T1D, showing value in distinguishing subjects with different diabetic complications. Being independent of the disease duration, these changes may be associated with the disease onset, making C3 N-glycome a potential novel marker of the disease progression and severity.
Effects of a novel rice-based diabetes-specific formula on postprandial glucose and gastrointestinal hormones: a double-blinded multi-arm randomized crossover trial
Authors: Chaiyakul Supat , Ketkham Narong , Chaichana Chartchai , Khumkhana Nanta , Deekum Wanjan , Wongshaya Pakwuan , Suwanmalai Thaniya , Hutchinson Carol , Pramyothin Pornpoj 
Published: May 2023

IntroductionWe developed a novel rice-based medical food for diabetes (MFDM) powder formula, using locally available ingredients in Thailand, which can potentially improve patient access to diabetes-specific formula (DSF) by reducing cost and improving availability.PurposeThe goals of our studies were to 1) measure the glycemic index (GI) and glycemic load (GL) of the MFDM powder formula in healthy individuals, and 2) assess postprandial glucose, insulin, satiety, hunger, and gastrointestinal (GI) hormone responses in adults with prediabetes or early type 2 diabetes after consuming MFDM in comparison with a commercially available standard formula (SF) and a DSF.MethodsIn Study 1, glycemic responses were assessed using the area under the curve (AUC), which was used to calculate GI and GL. Study 2 was a double-blinded multi-arm randomized crossover trial enrolling participants with either prediabetes or type 2 diabetes of ≤6 years. At each study visit, participants consumed either MFDM, SF, or DSF which contained 25 g of carbohydrates. Hunger and satiety were assessed using a visual analog scale (VAS). Glucose, insulin, and GI hormones were assessed using AUC.ResultsAll participants tolerated the MFDM well with no adverse events. In Study 1, the measured GI was 39 ± 6 (low GI) and GL was 11 ± 2 (medium GL). In Study 2, glucose and insulin responses were significantly lower after MFDM compared with SF (p-value&lt;0.01 for both), however, those responses were similar between MFDM and DSF. MFDM suppressed hunger, promoted satiety, stimulated active GLP-1, GIP, and PYY, and suppressed active ghrelin although these changes were similar to SF and DSF.ConclusionsMFDM had a low GI and a low-to-medium GL. In people with prediabetes or early type 2 diabetes, MFDM elicited reduced glucose and insulin responses when compared with SF. Rice-based MFDM may be an option for patients who are at risk for postprandial hyperglycemia.Clinical Trial Registrationhttps://www.thaiclinicaltrials.org/show/TCTR20210731001, identifier TCTR20210731001; https://www.thaiclinicaltrials.org/show/TCTR20210730007, identifier TCTR20210730007.
Causal inference between aggressive extrathyroidal extension and survival in papillary thyroid cancer: a propensity score matching and weighting analysis
Authors: Xu Ming , Xi Zihan , Zhao Qiuyang , Yang Wen , Tan Jie , Yi Pengfei , Zhou Jun , Huang Tao 
Published: May 2023

BackgroundExtrathyroidal extension is a major risk factor for poor prognosis in papillary thyroid cancer. However, the effect of different degrees of extrathyroidal extension on prognosis remains controversial. We performed a retrospective study to elucidate how the extent of extrathyroidal extension in papillary thyroid cancer affected the clinical prognosis of patients and its covariates.MethodsThe study included 108,426 patients with papillary thyroid cancer. We categorized the extent of extension into none, capsule, strap muscles, and other organs. Three causal inference methods for retrospective studies, namely, inverse probability of treatment weighting, standardized mortality ratio weighting, and propensity score matching analysis, were used to minimize potential selection bias. Kaplan–Meier analysis and univariate Cox regression analyses were applied to analyze the precise effect of ETE on survival in papillary thyroid cancer patients.ResultsIn the Kaplan–Meier survival analysis, only extrathyroidal extension into or beyond the strap muscles was statistically significant for both overall survival (OS) and thyroid cancer-specific survival (TCSS). In univariate Cox regression analyses before and after matching or weighting based on causal inference, extrathyroidal extension into soft tissues or other organs is a high-risk factor for both overall survival and thyroid cancer-specific survival. Sensitivity analysis revealed that lower overall survival was observed in patients with older age (≥55) and larger tumor size (&gt;2 cm) of papillary thyroid cancer with extrathyroidal extension into or beyond the strap muscles.ConclusionsOur study indicates that extrathyroidal extension into soft tissues or other organs is a high-risk factor in all papillary thyroid cancer. Even though invasion into the strap muscles did not seem to be a marker for poor prognosis, it still impaired the overall survival of patients with older age (≥55 years old) or larger tumor size (&gt;2 cm). Further investigation is needed to confirm our results and to clarify further risk factors independent of extrathyroidal extension.
Perinatal and postnatal exposure to phthalates and early neurodevelopment at 6 months in healthy infants born at term
Authors: Lucaccioni Laura , Palandri Lucia , Passini Erica , Trevisani Viola , Calandra Buonaura Filippo , Bertoncelli Natascia , Talucci Giovanna , Ferrari Angela , Ferrari Eleonora , Predieri Barbara , Facchinetti Fabio , Iughetti Lorenzo , Righi Elena 
Published: May 2023

BackgroundPhthalates are non-persistent chemicals largely used as plasticizers and considered ubiquitous pollutants with endocrine disrupting activity. The exposure during sensible temporal windows as pregnancy and early childhood, may influence physiological neurodevelopment.Aims and ScopeThe aim of this study is to analyze the relationship between the urinary levels of phthalate metabolites in newborn and infants and the global development measured by the Griffiths Scales of Children Development (GSCD) at six months.MethodsLongitudinal cohort study in healthy Italian term newborn and their mothers from birth to the first 6 months of life. Urine samples were collected at respectively 0 (T0), 3 (T3), 6 (T6) months, and around the delivery for mothers. Urine samples were analyzed for a total of 7 major phthalate metabolites of 5 of the most commonly used phthalates. At six months of age a global child development assessment using the third edition of the Griffith Scales of Child Development (GSCD III) was performed in 104 participants.ResultsIn a total of 387 urine samples, the seven metabolites analyzed appeared widespread and were detected in most of the urine samples collected at any time of sampling (66-100%). At six months most of the Developmental Quotients (DQs) falls in average range, except for the subscale B, which presents a DQ median score of 87 (85-95). Adjusted linear regressions between DQs and urinary phthalate metabolite concentrations in mothers at T0 and in infants at T0, T3 and T6 identified several negative associations both for infants’ and mothers especially for DEHP and MBzP. Moreover, once stratified by children’s sex, negative associations were found in boys while positive in girls.ConclusionsPhthalates exposure is widespread, especially for not regulated compounds. Urinary phthalate metabolites were found to be associated to GSCD III scores, showing inverse association with higher phthalate levels related to lower development scores. Our data suggested differences related to the child’s sex.