bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined effects of methadone and quetiapine on respiratory rate, haemodynamic variables, and temperature in conscious rats
Authors: Andersen Freja Drost , Steffensen Simon Comerma , Vistisen Simon Tilma , Pinilla Estefano , Pedersen Tina Myhre , Matchkov Vladimir , Simonsen Ulf , Andersen Charlotte Uggerhøj 
Published: August 2023

AbstractFatal poisonings where both methadone and quetiapine are detected post‐mortem occurs frequently in legal autopsy cases. It is unclear whether quetiapine increases the risk of fatal methadone poisoning or if it is merely detected due to widespread use. We hypothesized that methadone and quetiapine would have additive toxic effects on respiratory rate, blood pressure, and the QTc‐interval. To investigate this hypothesis, we used telemetry implants for measurements of respiratory rate, haemodynamic variables, the velocity of blood pressure changes, temperature, and movement in conscious, freely moving male Wistar rats aged 12–13 weeks. The combined effects of three accumulative i.p. doses of methadone (2.5, 10, 15 mg/kg) and quetiapine (3, 10, 30 mg/kg) were compared to rats treated with the same doses of each drug alone, and a vehicle‐treated group in a randomized investigator blinded study. No additive effects of quetiapine and methadone on respiratory rate, haemodynamic variables, or movement were observed. However, body temperature was significantly lower by approximately 1.5°C on average in the group treated with both methadone and quetiapine (15 + 30 mg/kg) compared to the other groups. This indicates a synergistic effect of quetiapine and methadone on thermoregulation, which may increase the risk of fatal poisoning. We suggest studying this finding further in human settings.
Scrutinizing the human TEX genes in the context of human male infertility
Authors: Sieper Marie. H. , Gaikwad Avinash S. , Fros Marion , Weber Philipp , Di Persio Sara , Oud Manon S. , Kliesch Sabine , Neuhaus Nina , Stallmeyer Birgit , Tüttelmann Frank , Wyrwoll Margot J. 
Published: August 2023

AbstractBackgroundInfertility affects around 15% of all couples worldwide and is increasingly linked to variants in genes specifically expressed in the testis. Well‐established causes of male infertility include pathogenic variants in the genes TEX11, TEX14, and TEX15, while few studies have recently reported variants in TEX13B, TEX13C, FAM9A (TEX39A), and FAM9B (TEX39B).ObjectivesWe aimed at screening for novel potential candidate genes among the human TEX (“testis expressed”) genes as well as verifying previously described disease associations in this set of genes.Materials and methodsTo this end, we screened the exome sequencing data of 1305 men, including 1056 crypto‐ and azoospermic individuals, and determined cell‐specific expression by analyzing testis‐specific single‐cell RNA sequencing data for genes with identified variants. To investigate the overarching role in male fertility, we generated testis‐specific knockdown (KD) models of all 10 orthologous TEX genes in Drosophila melanogaster.ResultsWe detected rare potential disease‐causing variants in TEX10, TEX13A, TEX13B, TEX13C, TEX13D, ZFAND3 (TEX27), TEX33, FAM9A (TEX39A), and FAM9B (TEX39B), in 28 infertile men, of which 15 men carried variants in TEX10, TEX27, and TEX33. The KD of TEX2, TEX9, TEX10, TEX13, ZFAND3 (TEX27), TEX28, TEX30, NFX1 (TEX42), TEX261, and UTP4 (TEX292) in Drosophila resulted in normal fertility.DiscussionBased on our findings, the autosomal dominant predicted genes TEX10 and ZFAND3 (TEX27) and the autosomal recessive predicted gene TEX33, which all three are conceivably required for germ cell maturation, were identified as novel potential candidate genes for human non‐obstructive azoospermia. We additionally identified hemizygous loss‐of‐function (LoF) variants in TEX13B, TEX13C, and FAM9A (TEX39A) as unlikely monogenic culprits of male infertility as LoF variants were also found in control men.ConclusionOur findings concerning the X‐linked genes TEX13B, TEX13C, and FAM9A (TEX39A) contradict previous reports and will decrease false‐positive reports in genetic diagnostics of azoospermic men.
Variations across Europe in hospitalization and management of pregnant women with SARS‐CoV‐2 during the initial phase of the pandemic: Multi‐national population‐based cohort study using the International Network of Obstetric Survey Systems (INOSS)
Authors: de Bruin Odette , Engjom Hilde , Vousden Nicola , Ramakrishnan Rema , Aabakke Anna J. M. , Äyräs Outi , Donati Serena , Jónasdóttir Eva , Knight Marian , Overtoom Evelien M. , Salvatore Michele A. , Sturkenboom Miriam C. J. M. , Svanvik Teresia , Varpula Reetta , Vercoutere An , Bloemenkamp Kitty W. M. ,   the INOSS COVID‐19 Working Group
Published: August 2023

AbstractIntroductionThe majority of data on COVID‐19 in pregnancy are not from sound population‐based active surveillance systems.Material and methodsWe conducted a multi‐national study of population‐based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS‐CoV‐2 PCR test ≤7 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID‐19‐related or non‐COVID‐19‐related. The primary outcome of interest was incidence of COVID‐19‐related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID‐19‐directed medical treatment.ResultsIn a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS‐CoV‐2; among them 940 (40%) were COVID‐19‐related admissions. The pooled incidence estimate for COVID‐19‐related admission was 0.59 (95% confidence interval 0.27–1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID‐19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%–13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID‐19‐related admission (range 14%–55%). Among 908 infants born to women in the COVID‐19‐related admission group, 5 (0.6%) stillbirths were reported.ConclusionsDuring the initial months of the pandemic, we found substantial variations in incidence of COVID‐19‐related admissions in nine European countries. Few pregnant women received COVID‐19‐directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics.
Cancer in pregnancy — The obstetrical management
Authors: Storgaard Lone , Greiber Iben Katinka , Pedersen Berit Woetmann , Nielsen Birgitte Bruun , Karlsen Mona Aarenstrup 
Published: August 2023

AbstractCancer in pregnancy, defined as a cancer diagnosed during pregnancy, is a rare but severe condition presenting both clinical and ethical challenges. During the last two decades a paradigm shift has occurred towards recommending similar staging and treatment regimens of pregnant and non‐pregnant cancer patients. This strategy is a result of an increasing number of reassuring reports on chemotherapy treatment in pregnancy after the first trimester. The management of cancer in pregnancy should be managed in a multidisciplinary team where staging, oncological treatment, social and mental care, timing of delivery, and follow‐up of the infant should be planned. Due to the rarity, centralization is recommended to allow experience accumulation. Furthermore, national and international advisory boards are supportive when there is a lack of expertise.
Neuroticism as an antecedent of abusive supervision and laissez‐faire leadership in emergent leaders: The role of facets and agreeableness as a moderator
Authors: Fosse Thomas Hol , Martinussen Monica , Sørlie Henrik O. , Skogstad Anders , Martinsen Øyvind L. , Einarsen Ståle Valvatne 
Published: August 2023

AbstractAcademic interest in the relationship between leaders' personality and subordinates’ perception of destructive leadership behavior is increasing. However, results so far have been weak, contradictory, and inconsistent to theory. Here, we examine if using facets of neuroticism, rather than the broader trait, can be more informative and increases the predictive power. Next, we explore the interplay between personality dimensions by examining if the relationship between the facet angry hostility in neuroticism and destructive leadership behavior is moderated by the trait agreeableness. Four hundred and twenty emergent leaders were examined in a military selection context, combining the leaders' self‐rated neuroticism (T1) with subordinates' subsequent perception of abusive supervision and laissez‐faire leadership in a field exercise two weeks later (T2). The results indicated that using facets instead of the broad factor of neuroticism improved the prediction of examined outcomes. Only some of the facets of neuroticism were related to perceived leader behavior, with specific facets being identified for abusive supervision and laissez‐faire leadership, respectively. Further, the relationship between angry hostility and both leadership styles was moderated by agreeableness.
Increasing healthcare costs in inflammatory bowel disease 2007–2020 in Sweden
Authors: Everhov Åsa H. , Söderling Jonas , Befrits Gustaf , Khalili Hamed , Bröms Gabriella , Neovius Martin ,   SWIBREG study group, Askling Johan , Halfvarson Jonas , Ludvigsson Jonas F. , Olén Ola 
Published: August 2023

SummaryBackgroundInflammatory bowel disease has been linked to increasing healthcare costs, but longitudinal data on other societal costs are scarce.AimTo assess costs, including productivity losses, in patients with prevalent Crohn's disease (CD) or ulcerative colitis (UC) in Sweden between 2007 and 2020.MethodsWe linked data from national registers on all patients with CD or UC and a matched (sex, birthyear, healthcare region and education) reference population. We assessed mean costs/year in Euros, inflation‐adjusted to 2020, for hospitalisations, out‐patient visits, medications, sick leave and disability pension. We defined excess costs as the mean difference between patients and matched comparators.ResultsBetween 2007 and 2020, absolute mean annual societal costs in working‐age (18–64 years) individuals decreased by 17% in CD (−24% in the comparators) and by 20% in UC (−27% in comparators), due to decreasing costs from sick leave and disability, a consequence of stricter sick leave regulations. Excess costs in 2007 were dominated by productivity losses. In 2020, excess costs were mostly healthcare costs. Absolute and excess costs increased in paediatric and elderly patients. Overall, costs for TNF inhibitors/targeted therapies increased by 274% in CD and 638% in UC, and the proportion treated increased from 5% to 26% in CD, and from 1% to 10% in UC.ConclusionBetween 2007 and 2020, excess costs shifted from productivity losses to direct healthcare costs; that is, the patients' compensation for sickness absence decreased, while society increased its spending on medications. Medication costs were driven both by expanding use of TNF inhibitors and by high costs for newer targeted therapies.
Proton pump inhibitor use and the risk of metachronous gastric cancer after H. pylori eradication in patients who underwent endoscopic resection for gastric neoplasms: A population‐based cohort study
Authors: Gong Eun Jeong , Jung Hye‐Kyung , Lee Bora , Hong Jitaek , Kim Jong Wook , Shin Cheol Min , Youn Young Hoon , Lee Kwang Jae 
Published: August 2023

SummaryBackgroundThe association between proton pump inhibitors (PPI) use and gastric cancer remains controversial.AimsTo investigate the impact of long‐term PPI use on metachronous gastric cancer after Helicobacter pylori eradication in high‐risk patients who underwent endoscopic resection of gastric neoplasms.MethodsUsing the Korean National Health Insurance Services database, we identified 1836 PPI users and 12,218 non‐users among patients who received H. pylori eradication therapy after endoscopic resection for gastric neoplasms between 2009 and 2014. We then compared the incidence of metachronous gastric cancer between the PPI user and non‐user groups. We conducted sensitivity analysis using various time lags and propensity score‐matched analysis to ensure the robustness of the results.ResultsAfter a median follow‐up of 7.3 years, the incidence of metachronous gastric cancer was significantly higher in the PPI user group than in the non‐user group, with a crude hazard ratio of 6.20 (95% confidence interval, 5.78–6.65). After adjustment, PPI use was associated with the development of metachronous gastric cancer, with an adjusted hazard ratio of 5.51 (95% confidence interval, 5.12–5.92). The PPI user group was categorised into three subgroups according to the cumulative PPI dose; the increased risk of metachronous gastric cancer remained significant regardless of the PPI dose. Moreover, these results remained robust after applying various time lags and propensity score‐matched analyses.ConclusionsLong‐term PPI use is associated with an increased risk of metachronous gastric cancer in patients who undergo H. pylori eradication therapy after endoscopic resection of gastric neoplasms.
Negation bias in communicating Asian American stereotypes
Authors: Elahi Rayan I. , Raser Roslyn G. , Benson Jessica M. 
Published: August 2023

AbstractPrevious literature demonstrates how the use of negations can be used to communicate stereotypic expectations (e.g., the professor is not smart, instead of stupid). In light of the COVID‐19 pandemic and increased discrimination against Asian Americans, we tested whether the negation bias is used to communicate stereotypes about Asian Americans. Participants were provided with stereotype‐consistent, stereotype‐inconsistent, and neutral scenarios about a subject portrayed as Asian American (Studies 1 and 2), or non‐Asian American (Study 2). They were then asked to choose between two descriptions (Study 1) or to describe their impressions of the subject (Study 2). Across studies, participants were more likely to use negations when describing stereotype‐inconsistent behavior compared to stereotype‐consistent behavior of Asian Americans, supporting our predictions. Results suggest that negations play a role in communicating previously held expectations of Asian Americans and are used in stereotype maintenance.
A test of the Morality‐Agency‐Communion (MAC) model of respect and liking across positive and negative traits
Authors: Prestwich Andrew 
Published: August 2023

AbstractThe Morality‐Agency‐Communion (MAC) model of respect and liking suggests that traits linked with morality are important for respect and liking; traits related to competence or assertiveness are important for respect and traits related to warmth are important for liking. However, tests of this model have tended not to consider traits related to immorality, incompetence, lack of assertiveness or coldness. This study addressed this issue by utilizing a within‐subjects design in which participants were required to rate their respect and liking for individuals with specific trait types across four categories (moral; competence; assertiveness; and warmth) at three levels (positive, negative and neutral). The central tenets of the MAC model were supported for ‘positive’ traits (morality, competence, assertiveness and warmth). However, for ‘negative’ traits (immorality, incompetence and lack of assertiveness), individuals were similarly not liked and not respected. Individuals who were cold were respected more than liked. The findings of this study extend the MAC model by indicating that the amount that individuals are respected versus liked depends not only on trait type but also whether a trait is positive or negative.
Extensive analysis of 59 sarcoma‐related fusion genes identified pazopanib as a potential inhibitor to COL1A1‐PDGFB fusion gene
Authors: Hirose Takeshi , Ikegami Masachika , Kojima Shinya , Yoshida Akihiko , Endo Makoto , Shimada Eijiro , Kanahori Masaya , Oyama Ryunosuke , Matsumoto Yoshihiro , Nakashima Yasuharu , Kawai Akira , Mano Hiroyuki , Kohsaka Shinji 
Published: August 2023

AbstractSarcomas are malignant mesenchymal tumors that are extremely rare and divergent. Fusion genes are involved in approximately 30% of sarcomas as driver oncogenes; however, their detailed functions are not fully understood. In this study, we determined the functional significance of 59 sarcoma‐related fusion genes. The transforming potential and drug sensitivities of these fusion genes were evaluated using a focus formation assay (FFA) and the mixed‐all‐nominated‐in‐one (MANO) method, respectively. The transcriptome was also examined using RNA sequencing of 3T3 cells transduced with each fusion gene. Approximately half (28/59, 47%) of the fusion genes exhibited transformation in the FFA assay, which was classified into five types based on the resulting phenotype. The sensitivity to 12 drugs including multityrosine kinase inhibitors was assessed using the MANO method and pazopanib was found to be more effective against cells expressing the COL1A1‐PDGFB fusion gene compared with the others. The downstream MAPK/AKT pathway was suppressed at the protein level following pazopanib treatment. The fusion genes were classified into four subgroups by cluster analysis of the gene expression data and gene set enrichment analysis. In summary, the oncogenicity and drug sensitivity of 59 fusion genes were simultaneously evaluated using a high‐throughput strategy. Pazopanib was selected as a candidate drug for sarcomas harboring the COL1A1‐PDGFB fusion gene. This assessment could be useful as a screening platform and provides a database to evaluate customized therapy for fusion gene‐associated sarcomas.
Curcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor‐associated macrophages and metastasis associated in colon cancer 1 (MACC1) expression
Authors: Ge Shuke , Sun Xu , Sang Limin , Zhang Min , Yan Xubo , Ju Qi , Ma Xuefeng , Xu Meng 
Published: August 2023

AbstractThe present study was to investigate the underlying mechanism of the antitumor effect of curcumin in colorectal cancer cells, focusing on the M2 polarization of tumor‐associated macrophages (TAMs). The effect of curcumin on the malignant behavior of colorectal cancer cells was investigated by WST assay for cell growth, and Transwell assay for cell migration/invasion. THP‐1 cells were differentiated into macrophages and coculture with colorectal cancer cells to study the influence of curcumin on M2 polarization, presenting as the levels of ARG1 mRNA, IL‐10, and CD163‐positive cells. GEO database was searched for the shared altered gene of curcumin in colorectal cells and human monocytes. Molecular docking was used to visualize the binding between curcumin and MACC1. Curcumin restricted the proliferation, apoptosis, and migration/invasion of HCT 116 and SW620 cells. Curcumin attenuated levels of the M2 macrophage markers, CD163 + cells, IL‐10 secretion, and ARG1 mRNA. MACC1 was a target of curcumin in colorectal cancer cells, relating to macrophage. Rescue experiments showed that MACC1 overexpression can reverse the antitumor effect of curcumin in colorectal cancer cells and M2 polarization of TAMs. Curcumin's antiproliferative and anti‐migratory effects in colorectal cancer cells may be mediated by MACC1 and inhibition of M2 polarization of TAMs.
Priming group identities affects children's resource distribution among groups
Authors: Nassir Yara , Diesendruck Gil 
Published: August 2023

AbstractThe present research investigated the effect of ethnic–national identity on intergroup attitudes among Israeli children. Between 2019 and 2020, 136 Arab Muslim and 136 Jewish 5‐ and 10‐year‐olds (boys and girls) participated in one of four ethnic–national identity conditions: ingroup, outgroup, common identity, and control. In each condition, participants were described a city whose residents were defined according to the condition. Then, children were asked to “release” positive and negative animals to an ingroup city, an outgroup city, or a zoo. The results showed that highlighting a common identity improved attitudes across all children, but effect of ingroup and outgroup emphases varied between Jewish and Arab children. These results highlight the different dynamics of social identities among majority and minority children.
Is Attachment and Biobehavioral Catch‐up effective for parents with insecure attachment states of mind?
Authors: Labella Madelyn H. , Raby K. Lee , Bourne Stacia V. , Trahan Alec C. , Katz Danielle , Dozier Mary 
Published: August 2023

AbstractPrior research suggests that attachment‐based interventions, including Attachment and Biobehavioral Catch‐up (ABC), may be less effective at enhancing parenting quality among parents who self‐report having an insecure attachment style. The current study tested whether effects of ABC on parental behavior were moderated by categorical and dimensional measures of attachment obtained via Adult Attachment Interviews with 454 parents who were approximately 34 years old, primarily female, and predominantly White or African American. Parents randomized to ABC exhibited higher sensitivity and positive regard, and lower intrusiveness shortly after the intervention than parents randomized to the control intervention (|β|s = .10–.27). The effect of ABC on intrusiveness persisted 2 years later. Effects at either timepoint were not significantly moderated by parents' attachment representations.
The panopticon looms: A gendered narrative of the interlocking powers of welfare intervention and criminalization
Authors: Clarke Becky , Leah  
Published: August 2023

AbstractThis paper presents a case study narrative of one woman. Drawing on her storied recollections, from infancy into childhood through young motherhood into adulthood, we trace the interlocking relationship between policies and practices intended to offer welfare support facilitating her criminalization. A collaborative approach to producing knowledge, representing 8 years of narrative, dialogue and reflection surfaces a looming panopticon. The gendered power of the state to intervene across the life course is revealed, as is the failed and harmful nature of this panopticon. Three distinct themes emerge from the analysis: the power to define and the fixing nature of gendered policy and practice narratives; the gendered control strategies that reproduce harms in women's lives; and the lifelong nature of the panopticon for some girls and women. Cutting across these experiences are processes of silencing and ultimately resistance, strategies for surviving the enduring forms of institutional surveillance and intervention. The paper closes with clear implications for the hegemonic trio of social science research and social work and criminal justice policy and practice. We must confront and dismantle our complicity in the silent silencing and gendered harms of the panopticon.