bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a new flippase-dependent mouse model for red fluorescence-based isolation of KRASG12D oncogene-expressing tumor cells
Authors: Hrckulak Dusan , Onhajzer Jakub , Krausova Michaela , Stastna Monika , Kriz Vitezslav , Janeckova Lucie , Korinek Vladimir 
Published: January 2025

AbstractProto-oncogene KRAS, GTPase (KRAS) is one of the most intensively studied oncogenes in cancer research. Although several mouse models allow for regulated expression of mutant KRAS, selective isolation and analysis of transforming or tumor cells that produce the KRAS oncogene remains a challenge. In our study, we present a knock-in model of oncogenic variant KRASG12D that enables the “activation” of KRASG12D expression together with production of red fluorescent protein tdTomato. Both proteins are expressed from the endogenous Kras locus after recombination of a transcriptional stop box in the genomic DNA by the enzyme flippase (Flp). We have demonstrated the functionality of the allele termed RedRas (abbreviated KrasRR) under in vitro conditions with mouse embryonic fibroblasts and organoids and in vivo in the lung and colon epithelium. After recombination with adenoviral vectors carrying the Flp gene, the KrasRR allele itself triggers formation of lung adenomas. In the colon epithelium, it causes the progression of adenomas that are triggered by the loss of tumor suppressor adenomatous polyposis coli (APC). Importantly, cells in which recombination has successfully occurred can be visualized and isolated using the fluorescence emitted by tdTomato. Furthermore, we show that KRASG12D production enables intestinal organoid growth independent of epidermal growth factor (EGF) signaling and that the KRASG12D function is effectively suppressed by specific inhibitor MRTX1133.
Analyzing the impacts of race, addiction, drug type, and criminal record on public support for criminalized and medicalized sentencing approaches toward illegal drug use
Authors: Caliman Carolina R. , Berryessa Colleen M. 
Published: January 2025

Abstract
Objectives
This study examines how a defendant’s addiction, prior criminal record, race, and drug type impact public support for criminalized and medicalized sentencing approaches to illegal drug use, as well as how such support may be moderated by participants’ levels of essentialist thinking.

Methods
This study is a fully-crossed, randomized experiment with a lay public sample (N = 1208).

Results
Public support for medicalized approaches to sentencing was significantly higher for oxycodone and heroin. Support for criminalized approaches was significantly higher for crack and cocaine, and when the defendant was Hispanic, Black, or had a violent criminal record. Essentialist thinking generally predicted increased support for criminalized approaches, but increased support for medicalized approaches when addiction was known.

Conclusions
This research highlights the role of different factors in shaping public support for drug sentencing approaches, as well as suggests that public attitudes about drugs are deeply intertwined with societal narratives about race, addiction, and criminality.
Ethics that Fails to Regulate War, Ethics that Enhances War
Authors: Lingis Alphonso , Komesaroff Paul 
Published: January 2025

AbstractThis short perspective piece argues that wars are often conducted in settings where ethical injunctions are ignored or overridden and where ethical oversight is avoided or circumvented. This is particularly the case with intrastate conflicts and is exacerbated by novel military technologies. In these and other settings ethics is often invoked actually to promote or prolong war.
Bullying and anxiety/depressive symptoms in Latinx adolescents living with obesity: the mediating role of self-esteem
Authors: Lovan Padideh , Boga Devina J. , Lozano Alyssa , Graefe Beck , Hodge Shanelle , Estrada Yannine , Lee Tae Kyoung , Prado Guillermo 
Published: January 2025

AbstractBullying is a serious public health issue for adolescents in the United States. Previous studies have demonstrated associations between self-esteem, anxiety/depressive symptoms, and bullying victimization (BV); however, these relationships have not been extensively studied considering the overlap of social identities of Latinx adolescents living with obesity and overweight (LAWO), who are more likely to be victims of bullying. The current study aims to address these gaps by examining the relationship between BV and anxiety/depressive symptoms and the role of self-esteem while considering sex differences among LAWO (N = 139; female: n = 77, 55.4%; mean age = 12.9 years). Results for overall group showed that BV significantly predicted anxiety/depressive symptoms and self-esteem significantly mediated this relationship. Multigroup mediation analysis resulted in significant mediation by self-esteem for females. Results suggest that interventions that target self-esteem and consider culture would be beneficial for female LAWO.
The dark side of humor: analyzing the relationship between dark triad traits, humor styles, and bullying in university students
Authors: Antoniadou Nafsika , Kokkinos Constantinos M. 
Published: January 2025

AbstractThis research uses a self-report questionnaire to examine how humour styles based on Martin’s taxonomy (affiliative, self-enhancing, aggressive, and self-defeating) may moderate the relationship between Dark Triad personality traits (Machiavellianism, narcissism, and psychopathy) and bullying behaviors among 662 university students. Significant positive correlations between Dark Triad traits and bullying emerged, as well as gender, with males scoring higher in all variables. Moderation analyses showed that affiliative humour reduced the impact of narcissism on bullying, while aggressive enhanced it. Additionally, self-enhancing and aggressive humour increased the impact of psychopathy on bullying behaviors. These results suggest that humour styles play a crucial role in the dynamics of bullying in relation to Dark Triad personality traits, offering new insights for intervention strategies.
Advances in pancreatic cancer treatment
Authors: Taghizadeh Hossein 
Published: January 2025

Summary
Pancreatic cancer, one of the most challenging malignancies to treat, is characterized by poor survival rates. The identification of novel effective therapies, optimization of treatments for the elderly population, and elucidation of the role of chemoradiotherapy are critical issues. Recent studies presented at the American Society of Clinical Oncology (ASCO) 2024 annual meeting have demonstrated advancements in the treatment of this aggressive disease. This review summarizes three notable studies: the phase I trial of IBI389, the phase II GIANT trial, and the phase II/III GABARNANCE trial, each contributing new insights into therapeutic strategies for pancreatic ductal adenocarcinoma (PDAC).
The past, present, and future of social media marketing ethics
Authors: Granstedt Anna 
Published: January 2025

Abstract
As social media increasingly permeates everyday life, ethical concerns about its use are coming into sharper focus. At the same time, the ethical issues involved in social media marketing have received somewhat limited attention from marketing research and practice. Therefore, many scholars are calling out for a better understanding of the role of ethics in social media marketing decisions. Current marketing ethics theories do not sufficiently consider the unique dynamics of social media. To aid researchers, practitioners, and policymakers, we propose a theoretical framework to address issues in social media marketing ethics built on theories of normative and descriptive ethics. This framework considers the normative and descriptive ethics within firm-internal and firm-external factors in the fields of law, regulation and norms, platform conditions, and stakeholder value. Then, applying a thematically built systematic literature review, we identify and discuss five distinct themes of research in social media marketing ethics: (I) advertising and customer–brand relationships; (II) the dark side of social media; (III) privacy; (IV) fake news; and (V) emerging research. These themes and their implications are discussed using the proposed theoretical framework. Our study provides a comprehensive overview and synthesis of ethical challenges in social media marketing and suggests possible research avenues for the future. In doing so, it outlines pressing issues that require attention from researchers, policymakers, and practitioners to ensure an ethically sustainable approach to social media marketing.
Preparation of RGO with Enhanced Electrical Conductivity: Effects of Sequential Reductions of L-Ascorbic Acid and Thermal
Authors: Öztekin Dilek , Arbağ Hüseyin , Yaşyerli Sena 
Published: January 2025

AbstractThis study aimed to prepare reduced graphene oxide (RGO) with high electrical conductivity by changing the reduction sequences with environmentally friendly L-ascorbic acid and H2 at moderate temperature. Graphene oxide (GO) was prepared by the modified Hummers method using graphite. The characteristic peak at about 2θ:10° was observed in the XRD pattern, and the oxygen-containing functional groups determined by FTIR analyses indicate the successful preparation of graphene oxide (GO) In order to investigate the removal of oxygen-containing functional groups from GO and the restoration of the graphene structure, XRD, ATR-FTIR, XPS, and Raman analysis were performed. Also, SEM images were taken to see the change in the morphology of the materials. Electrical conductivity measurements of prepared GO and RGO materials were performed using the four-point probe method. RGO-AA-T material, to which first chemical and then thermal reduction is applied, was found to have the highest electrical conductivity value of 1.97 × 104 Sm−1 with the highest ratio of C/O:15.5 among other RGOs. XRD and Raman analysis results showed that the initial application of chemical reduction allowed the formation of fewer graphene layers and denser sp2 domains responsible for the highest electrical conductivity among other materials. The sequence of chemical and thermal treatment significantly enhances the electrical conductivity of RGO by effectively removing oxygen functional groups, maximizing the restoration of sp2 domains, and preserving structure. These results indicate that the chemical and thermal reduction sequence is very important in improving electrical conductivity. The chemical and thermal reduction applied in this study is a very promising method, and ten times higher electrical conductivity can be achieved compared to the literature.
Naming, Stimulus Equivalence and Relational Frame Theory: Stronger Together than Apart
Authors: Regaço Alceu , Harte Colin , Barnes-Holmes Dermot , Leslie Julian , de Rose Julio C. 
Published: January 2025

AbstractResearch on human language started to change when Murray Sidman and colleagues demonstrated that a participant was able to derive unreinforced stimulus relations after conditional discrimination training. This work provided the basis for a novel approach to research on symbolic behavior and fostered the development of three main theoretical accounts: stimulus equivalence (SE), relational frame theory (RFT), and naming theory (NT). These accounts unfolded in the last decades of the twentieth century, promoting intense debate and discussion within behavior analysis. Although experimental research emerging from these three accounts is still highly active today, the theoretical discussions have, to a large extent, faded. Considering the importance of rekindling a dialogue, this article aims to describe the differences among the three accounts, but focus on their common points. We conclude by arguing that developing a more complete behavior-analytic account of human language would be served best by considering both research and theoretical analyses of SE, RFT and NT. Finally, we provide examples of two successful research groups that adopted this approach and in doing so have advanced our understanding of language within behavior analysis.
In Which Scenarios Do Preceptors and Students Agree, Disagree, or Remain Neutral About Learner Mistreatment?
Authors: Colón-López Alejandra , Zinski Anne 
Published: January 2025

Abstract
Objective
In recent years, nearly half of graduating medical students in the USA and Canada reported personal mistreatment experiences during training. Prior scholarship reports heterogeneous opinions of learner mistreatment behaviors among trainees, and resulting unaligned perceptions may influence reporting, feedback, and policy. However, fewer studies compare students’ and preceptors’ views about learner mistreatment using vignettes of student-preceptor interactions.

Methods
We surveyed 141 students and 203 preceptors at an MD-granting institution. Participants indicated their agreement on a 5-point scale on whether behaviors in 17 written vignettes constituted learner mistreatment. Descriptive statistics and bivariate tests were executed to identify areas in which students’ and preceptors’ mistreatment views differed.

Results
Student and preceptor responses converged on 12 of 17 vignettes. More students agreed that vignettes describing a student being addressed by another student’s name and an example of public embarrassment constitutes learner mistreatment. More preceptors agreed that addressing students with terms of endearment and denying training opportunities based on career choice constitute learner mistreatment. The proportion of preceptors who selected neutral responses was higher than that of students for nearly all vignettes.

Conclusion
When presented with written vignettes, students’ and preceptors’ perceptions of learner mistreatment were not consistent. This study highlights potential gaps in students’ and preceptors’ mistreatment perceptions, including differences in participants’ decisions to remain “neutral.” To prevent and address learner mistreatment, follow-up research is warranted to support the development and honing of shared definitions and examples of mistreatment, as well as targeted programming for students and preceptors.
Patriarchy, Fertility and Excess Female Child Mortality in India
Authors: Singh Abhishek , Kumar Kaushalendra , McDougal Lotus , Chokhandre Praveen Kumar , Singh Ajeet Kumar , Upadhyay Ashish Kumar , James K. S. , Raj Anita 
Published: January 2025

AbstractResearch investigating association between patriarchy and demographic behavior is limited in India. The only study on this subject utilized 1981 Indian Census data to examine associations between patriarchy and fertility. We examined the association of patriarchy, measured using India Patriarchy Index (IPI), with total fertility rate (TFR) and excess female child mortality in India. Additionally, we examined independent associations of the 5 dimensions included in the IPI with the two outcomes. We used univariate and bivariate Local Indicators of Spatial Autocorrelation, multivariable ordinary least squares and spatial error- regressions to examine the associations. Spatial heterogeneity beyond the north–south divide was evident in the spatial association of IPI with TFR and excess female child mortality. Results show positive association of IPI with TFR and excess female child mortality. While son preference and socio-economic domination were positively associated with TFR, domination of men over women and son preference were positively associated with excess female child mortality. This study is the first of its kind to examine the association of a novel measure of patriarchy with TFR and excess female child mortality. As patriarchy is deep-rooted in Indian society, a great deal of effort is needed to shift these traditionally held social norms and practices.
Adversarialism and power-sharing: the effect of political competition on the management-performance relationship
Authors: Bello-Gomez Ricardo A. , Avellaneda Claudia N. , Olvera Johabed G. 
Published: January 2025

Abstract
We analyze the moderating effect of political contexts on the management-performance relationship. Dissimilar party systems generate different patterns of political competition, such as adversarialism versus power-sharing. We argue adversarialism strengthens the effect of chief executives’ experience on government performance by offering more incentives for competition and accountability, compared to power-sharing systems. Although Colombian and Mexican subnational governments share several institutional similarities, Mexico exhibits more adversarial competition, compared to Colombia’s power-sharing tradition. Therefore, governors’ background experience should be more strongly associated with gubernatorial performance in Mexico than in Colombia. We built panel data sets for the 32 Mexican states and the 32 Colombian departamentos by collecting governors’ biographical information, regional characteristics, and performance indicators for education (high school enrollment) and health (infant mortality rate). Findings indicate governors’ experience enhances performance in Mexican states, but not in Colombian departamentos. These suggest political competition patterns condition the role of executive experience on performance.
Can “energy-saving and emission reduction” demonstration city pilot alleviate carbon inequality in Chinese cities?
Authors: Fang Yong , Li Minghao , Chen Xueyan , Wang Chuyuan 
Published: January 2025

AbstractAs a pivotal element in China’s pursuit of a sustainable development model, green fiscal policies have become increasingly important amid the exacerbation of global climate conditions. Regrettably, little attention has been paid to comprehending the carbon allocation effects of the implementation of these policies. This study focuses on the “National Comprehensive Demonstration City of Energy Saving and Emission Reduction Fiscal Policy” (ESER policy) as the focal point of analysis. Using a multi-period difference-in-differences model, we assessed the implications of ESER policies on carbon inequality. This study further explored asymmetry, mechanism effects, and heterogeneity. Our empirical findings demonstrate that the ESER policy directly reduced carbon inequality by 11.4% in the demonstration cities. This conclusion withstood rigorous testing, including parallel trend assessments, robustness analyses, and endogeneity diagnostics. Moreover, the ameliorative implications of the ESER policy on carbon inequality in demonstration cities are predominantly realized by facilitating cleaner production technological innovation, end-of-pipe treatment technological innovation, industrial structure rationalization, and industrial structure optimization. Furthermore, the ameliorative implications of the ESER policy on carbon inequality were conspicuous in the upper quantiles. Finally, the urban magnitude, geographical location, resource endowment, and innovation foundation of a demonstration city exert diverse influences on policy implementation. These empirical results provide valuable guidance for the Chinese government in formulating climate policies with a focus on carbon equity considerations.
In Response to Constitutional Crisis: The Latent Carl Schmitt in Zhang Junmai’s Political Thought
Authors: Chen Dandan 
Published: January 2025

AbstractThis paper examines two responses to the global constitutional crises in the twentieth century, with a focus on a comparison between Carl Schmitt, a notorious German political theorist and critic of liberal constitutionalism and Zhang Junmai, a constitutionalist in Republican China. After the First World War, both Germany and China experienced constitutional crises, which prompted critical reflections among intellectuals. My paper is the first to discover and examine the latent element of Carl Schmitt in Zhang Junmai’s acceptance of the Weimar Constitution. My research shows that Zhang’s 1930 article, “Hugo Preuss (Author of the New German Constitution), His Concept of the State and His Position in the History of German Political Theory” (德國新憲起草者柏呂斯之國家觀念及其在德國政治學說史上之地位) is his Chinese translation of Carl Schmitt’s 1930 article, “Hugo Preuss: His Concept of the State and His Position in German State Theory” (“Hugo Preuss: Sein Staatsbegriff und seine Stellung in der deutschen Staatslehre”). Instead of simply regarding Zhang’s writing as plagiarism, my paper interrogates the gaps between Carl Schmitt’s original text and Zhang’s translation. By examining the intertextual relation between Carl Schmitt and Zhang Junmai, this paper reveals a latent aspect of the spectrum of Constitutionalism in the twentieth century and shows a special dialogue between a German critic of constitutionalism and a Chinese constitutionalist.
An Existential Attention Norm for Affectively Biased Sentient Beings: A Buddhist Intervention from Buddhaghosa
Authors: SMITH SEAN M. 
Published: January 2025

ABSTRACT
This article argues that our attention is pervasively biased by embodied affects and that we are normatively assessable in light of this. From a contemporary perspective, normative theorizing about attention is a relatively new trend (Siegel 2017: Ch. 9, Irving 2019, Bommarito 2018: Ch. 5). However, Buddhist philosophy has provided us with a well-spring of normatively rich theorizing about attention from its inception. This article will address how norms of attention are dealt with in Buddhaghosa’s (5th-6th CE) claims about how wholesome forms of empathy can go wrong. Through this analysis, I will show that Buddhist philosophers like Buddhaghosa think there is an existential norm of attention, one that commands us not just to pay attention to ourselves and the world properly, but one whereby we are exhorted to attend to ourselves in a way that gradually transforms our cognitive-emotional constitution so that we become liberated from suffering.
Forecasting mortality rates with functional signatures
Authors: Yap Zhong Jing , Pathmanathan Dharini , Dabo-Niang Sophie 
Published: January 2025

AbstractThis study introduces an innovative methodology for mortality forecasting, which integrates signature-based methods within the functional data framework of the Hyndman–Ullah (HU) model. This new approach, termed the Hyndman–Ullah with truncated signatures (HUts) model, aims to enhance the accuracy and robustness of mortality predictions. By utilizing signature regression, the HUts model is able to capture complex, nonlinear dependencies in mortality data which enhances forecasting accuracy across various demographic conditions. The model is applied to mortality data from 12 countries, comparing its forecasting performance against variants of the HU models across multiple forecast horizons. Our findings indicate that overall the HUts model not only provides more precise point forecasts but also shows robustness against data irregularities, such as those observed in countries with historical outliers. The integration of signature-based methods enables the HUts model to capture complex patterns in mortality data, making it a powerful tool for actuaries and demographers. Prediction intervals are also constructed with bootstrapping methods.