bluuebunny/crossref_metadata_2025_split huggingface dataset:
SALL4 as an indicator for the diagnosis of hepatoid carcinoma of the ovary: A case report and literature review
Authors: Li Jiana , Wu Xiaohua 
Published: July 2023

Key Clinical MessagePrimary HCO is a rare, aggressive ovarian malignant tumor, morphologically resembling HCC. SALL4 can be adopted to differentiate HCO from HCC. The serum AFP and CA125 rather than HE4 can be employed as possible biomarkers to track treatment and monitor recurrence.AbstractWe report a case of a postmenopausal woman presenting with lower abdominal pain and vaginal bleeding. She went through a maximal debulking surgery, and the pathological biopsy revealed hepatoid carcinoma of the ovary (HCO). Immunohistochemical assay demonstrates SALL4 as an indicator to differentiate HCO from hepatocellular carcinoma (HCC).
Hybrid surgery of arteriovenous malformation and aneurysm of the sole
Authors: Nazari Iraj , Mousavi Seyyed Masoud , Zargar Mohammad Amin , Alavi Seyed Mohammad Amin 
Published: July 2023

Key Clinical MessageThe study describes the successful treatment of a rare type of arteriovenous malformation (AVM) in the sole using hybrid surgery, which consists of open resection and embolization. Moreover, the possibility of utilizing ultrasound during examination in addition to angiography for the diagnosing of AVM of the sole is proposed.
Report of two cases of Schaaf‐Yang syndrome: Same genotype and different phenotype
Authors: Rodriguez Ana Maria , Schain Katherine , Jayakar Parul , Wright Meredith S. , Chowdhury Shimul , Salyakina Daria 
Published: July 2023

Key Clinical MessageWe report two, genotypically identical but phenotypically distinct cases of Schaaf‐Yang syndrome and propose the early use of Genome Sequencing in patients with nonspecific presentations to facilitate the early diagnosis of children with rare genetic diseases and improve overall health care outcomes.
Chiroptical Recognition of Carboxylates with Charge‐Neutral Double‐Stranded Zinc(II) Helicates
Authors: Kalarikkal Malavika G. , Drechsler Christoph , Tusha Gers , Schäfer Lars V. , Van Craen David 
Published: July 2023

AbstractChirality analysis of small molecules for the determination of their enantiopurity is nowadays ruled by streamlined chromatographic methods which utilize chiral stationary phases. Chiroptical probes which rely on host–guest interactions are so far overshadowed by the latter but have the benefit of depending only on common spectroscopic techniques such as CD spectroscopy to distinguish enantiomers and to quantify their ratio. Interest into this receptor‐based approach is constantly rising because non‐invasive high‐throughput screenings with a minimal waste production can be performed. In this study we investigate the possibility to utilize metal‐based containers in form of charge‐neutral helicates able to recognize anions for this purpose. Key building block of the helicates are triazole units which show rotational freedom and give rise to either a meso‐structure or a racemic mixture of the right‐ and left‐handed complex. A chiroptical response of the probe is observed upon recognition of chiral mono‐ or dicarboxylates and chirality analysis of tartrate is conducted by CD spectroscopy.
Iso‐Pentadienyl Carbonate as a Five Carbon Synthon in Manganese(I)‐Catalyzed Selective Linear 1,3‐Dienylation
Authors: Singh Shubham , Parammal Athira , Kumar Manoj , X Joe Sam , Subramanian Parthasarathi 
Published: July 2023

AbstractSelective linear 1,3‐dienylations are essential transformations, and numerous synthetic efforts have been documented. However, a general method enabling access to electron‐rich, ‐poor, and biologically relevant dienyl molecules is in high demand. Hence, we report a straightforward method of manganese(I)‐catalyzed C−H dienylation of arenes by using iso‐pentadienyl carbonate as a five carbon synthon. This is a highly unprecedented report for selective linear 1,3‐dienylation using manganese C−H activation catalysis. Our method facilitates the synthesis of varieties of dienes, including those suitable for normal or inverse electron demand Diels‐Alder reactions, dienyl glycoconjugates, and unnatural amino acids. Extensive mechanistic studies, including isolation of C−H activated organo‐manganese complex and isotopic analyses, have supported the proposed mechanism of this dienylation. The synthetic applicability of this method eased to deliver a 6/6/5‐fused tricyclic nagilactone scaffold.
Electrolysis of Direct Seawater: Challenges, Strategies, and Future Prospects†
Authors: Hu Lin , Tan Xiao , Yang Xuhao , Zhang Kan 
Published: July 2023

Comprehensive SummaryThe use of renewable sources such as solar, ocean, geothermal, and wind energy to drive water electrolysis reactions to obtain green and clean hydrogen fuels is one of the important paths to achieve sustainable energy development. At present, most water electrolysis technologies need to conduct corresponding pre‐processing, such as diluting water sources and purifying dehydration, which will greatly increase operating costs. The development of direct seawater electrolytic process can effectively solve the above problems. Here, we review the latest progress of the electrode materials and catalysts of the direct electrolysis process of seawater, and discuss how to design high activity and high‐selective electrode materials for water electrolysis with familiar impurities (such as chloride, metal ions and biological organisms) existing in the future.
Joint modelling of quantile regression for longitudinal data with information observation times and a terminal event
Authors: Pang Weicai , Liu Yutao , Zhao Xingqiu , Zhou Yong 
Published: July 2023

AbstractLongitudinal data arise frequently in biomedical follow‐up observation studies. Conditional mean regression and conditional quantile regression are two popular approaches to model longitudinal data. Many results are derived under the case where the response variables are independent of the observation times. In this article, we propose a quantile regression model for the analysis of longitudinal data, where the longitudinal responses are allowed to not only depend on the past observation history but also associate with a terminal event (e.g., death). Non‐smoothing estimating equation approaches are developed to estimate parameters, and the consistency and asymptotic normality of the proposed estimators are established. The asymptotic variance is estimated by a resampling method. A majorize‐minimize algorithm is proposed to compute the proposed estimators. Simulation studies show that the proposed estimators perform well, and an HIV‐RNA dataset is used to illustrate the proposed method.
The incidence of subclinical atherosclerosis in subjects with low and moderate cardiovascular risk
Authors: Li Yan , Zhang Yinghua , Xiao Keling , Si Jin , Zhang Haoyu , Sun Lijie , Miao Zupei , Zhao Ting , Sun Jinghao , Sun Xipeng , Liu Zhi , Gao Jing , Zhao Jing , Chu Xi , Li Jing 
Published: July 2023

AbstractBackgroundThe cardiovascular risk models and subclinical atherosclerotic indicators are both recommended for cardiovascular risk stratification. The accordance between the incidence of subclinical atherosclerosis and subjects with low and moderate cardiovascular risk is unclear.HypothesisSubjects with low and moderate cardiovascular risk have a lower incidence of subclinical atherosclerosis compared with subjects with high risk.MethodsBrachial‐ankle pulse wave velocity (BaPWV) and brachial flow‐mediated dilation (BFMD) were measured in 421 subjects without a history of atherosclerotic cardiovascular disease (ASCVD) from October 2016 to January 2020. All subjects were classified into low, moderate, and high risk based on Framingham and China‐par risk models respectively.ResultsMean age was 57.05 ± 9.35 years and 248 (58.9%) were male. In subjects with low, moderate, and high risk assessed by Framingham and China‐par risk models, the percentage of abnormal BaPWV ( > 1400 cm/s) was 42.9%, 70.1%, 85.7%, and 40.4%, 71.4%, 89.7%, respectively. Meanwhile, the percentage of abnormal BFMD ( ≤ 7%) was 43.8%, 68.5%, 77.3%, and 44.9%,72.1%, and 76.6%. According to Framingham‐based high‐risk categories, positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity for BaPWV abnormality were 85.7%, 39.4%, 36.1%, and 87.5%, respectively. For BFMD abnormality, the values were 77.3%, 40.1%, 34.1%, and 81.8%, respectively. According to China‐par high‐risk categories, the values for BaPWV abnormality were 89.7%, 43.8%, 45.6%, and 89.0%, respectively. For BFMD abnormality, the values were 76.6%, 41.3%, 40.7%, and 77%, respectively. In multivariate analysis, age and blood pressure were the independent predictors for subclinical atherosclerosis in subjects with low‐moderate risk.ConclusionsMore than one‐half of subjects with low and moderate risk already have detectable subclinical atherosclerosis, indicating higher cardiovascular risk beyond the traditional stratification.
Single BRAFV600E mutation is not associated with aggressive biological behavior in adolescent and pediatric papillary thyroid carcinoma
Authors: Zhou Bin , Lu Xiaoyu , Hei Hu , Zhang Songtao , Li Yanqing , Fang Jugao , Qin Jianwu , Ge Hong 
Published: July 2023

AbstractBackgroundPapillary thyroid carcinoma is more likely to show aggressive biological behaviors in the majority of pediatric patients than in adult patients. The aim of this study was to investigate the mutation rate of the BRAFV600E gene in adolescents and children with papillary thyroid carcinoma and to analyze the association between BRAFV600E gene mutation and tumor‐aggressive pathological factors.MethodsA total of 42 pediatric patients with papillary thyroid carcinoma who underwent thyroid surgery from 2017 to 2022 were studied retrospectively. Whether the BRAFV600E gene mutation in papillary thyroid carcinoma was related to aggressive biological behavior was analyzed.ResultsAmong the 42 pediatric patients with papillary thyroid carcinoma, the median patient age was 15.71 ± 2.51 years (mean ± SD) and the median tumor diameter was 24.95 ± 12.29 mm (mean ± SD). Among all enrolled patients, the mutation rate of the BRAFV600E gene was 54.76% (23 of 42). There were 33 patients with classic papillary thyroid carcinoma, and 22 (66.67%) with classic subtypes were BRAFV600E positive. The BRAFV600E mutation was associated with lower distant metastasis (p = .013) and less Hashimoto’s thyroiditis (p = .006). There was no significant difference in clinicopathological factors such as sex, age, tumor size, capsular invasion, multifocality, hypothyroidism, recurrence, lymph node metastasis, and extrathyroidal extension.ConclusionsThe BRAFV600E mutation is not uncommon in pediatric papillary thyroid carcinoma but is not significantly associated with aggressive biological behavior. It is not possible to determine whether to adopt more active diagnosis and treatment measures on the basis of the mutation of a single BRAFV600E gene.
Species richness and functional diversity enhance winter annual forage productivity and nutritive value
Authors: Rusch Hannah L. , Dubeux Jose C. B. , Queiroz Luana M. Dantas , Wallau Marcelo O. , Wilson Chris H. 
Published: July 2023

AbstractWinter annual forages can extend grazing into the cool‐season in the US southeast, however uncertainty regarding potential tradeoffs between winter annual mixtures versus monocultures exists. We examined increasingly species‐rich and functionally diverse winter annual forage mixtures at two Florida locations to evaluate impacts of including more plant species with distinct traits (e.g., different maturities and nitrogen [N] scavenging vs. N2‐fixing capabilities) on forage accumulation (FA), nutritive value, and evenness of forage distribution across the cool‐season compared with a rye (Secale cerealeL.) monoculture. Furthermore, we quantified the N2‐fixing potential of winter annual legumes to measure their contribution to soil fertility and ecosystem N cycling. We found that greater species richness enhanced total cool‐season FA at both sites, ranging from 0.92 to 4.38 Mg DM ha−1in Gainesville and 6.48 to 9.11 Mg DM ha−1in Marianna. In Marianna, where legumes accounted for approximately 25% or more of the biomass accumulated by winter annual forage mixtures, legume inclusion enhanced forage shoot N concentration. Furthermore, >50% of the N in legume tissues derived from the atmosphere, supplying 0.18–2 kg N ha−1in Gainesville and 30–52 kg N ha−1in Marianna. Altogether, our data suggest that species richness enhanced winter annual forage production and legume inclusion improved forage nutritive value although these responses were site‐specific. Thus, our multi‐site study provides information that can guide decision‐making regarding appropriate winter annual forage selections to increase cool‐season forage production in the southeastern United States.
Re‐evaluating the Magnesium‐ion Storage Capability of Vanadium Dioxide, VO2(B): Uncovering the Influence of Water Content on the Previously Overestimated High Capacity
Authors: Setiawan Dedy , Chae Munseok S. , Hong Seung‐Tae 
Published: July 2023

AbstractMagnesium batteries have emerged as a promising alternative to lithium‐ion batteries due to their theoretical high energy density and abundant magnesium resources. Vanadium dioxide, VO2(B), has been reported as a high‐capacity cathode material for magnesium batteries. However, the electrochemical intercalation mechanism requires further elucidation due to a limited understanding of the structure‐property relationship. In this study, we re‐evaluated the magnesium storage capability of the material, with a particular focus on the influence of water content in nonaqueous electrolytes. The higher discharge capacity of 250 mAh g−1 is achieved exclusively in the wet electrolyte with 650 ppm water content. A significantly lower capacity of 51 mAh g−1 was observed in the dry electrolyte solution containing 40 ppm water content. Through X‐ray structural and elemental analyses, as well as magnesium‐ion diffusion pathway analysis using bond‐valence‐energy‐landscape calculations, the restricted capacity was clarified by examining the reaction mechanism. According to this study, the impressive capacity of magnesium‐ion battery cathodes may be exaggerated due to the involvement of non‐magnesium‐ion insertion unless the electrolytes′ water content is appropriately regulated.
Closed‐Loop Recyclable Poly(imine‐acetal)s with Dual‐Cleavable Bonds for Primary Building Block Recovery
Authors: Saito Keita , Türel Tankut , Eisenreich Fabian , Tomović Željko 
Published: July 2023

AbstractChemical recycling offers a promising solution for the end‐of‐life treatment of synthetic polymers. However, the efficient recovery of well‐defined recycled building blocks continues to be a major challenge, especially for crosslinked thermosets. Here, we developed vanillin‐based polymer networks functionalized with dual‐cleavable imine and acetal bonds that facilitate chemical recycling to primary building blocks and their convenient separation at the molecular level. A library of crosslinked poly(imine‐acetal)s was synthesized by combining the in‐bulk synthesized liquid di‐vanillin acetal monomer (DVA) with commercially available liquid di‐ and triamines under solvent‐free conditions. These thermosets showed tailor‐made thermal and mechanical properties along with outstanding chemical recyclability. Under aqueous acidic conditions, poly(imine‐acetal)s selectively and completely disintegrate into small molecules. During the polymer design stage, these compounds were carefully selected to enable facile separation without tedious techniques. As a result, the primary building blocks were isolated in high yields and purity and immediately reused to produce fresh polymers with identical thermomechanical properties. Since our “design for recycling” concept aims at obtaining the primary building blocks rather than monomers after depolymerization, a plethora of possibilities are unlocked to utilize these chemical resources, including closed‐loop recycling as portrayed.
CH selection and compressive sensing‐based data aggregation in WSN using hybrid Golden circle‐inspired optimization
Authors: T P Rani , Srinadh Vemireddi , P Mano Paul , J.P Ananth 
Published: July 2023

SummaryThe arbitrary distribution of sensor nodes and irregularity of the routing path led to unordered data, which is complex to handle in a wireless sensor network (WSN). To increase WSN lifetime, data aggregation models are developed to minimize energy consumption or ease the computational burden of nodes. The compressive sensing (CS) provides a new technique for prolonging the WSN lifetime. A hybrid optimized model is devised for cluster head (CH) selection and CS‐based data aggregation in WSN. The method aids to balance the energy amidst different nodes and elevated the lifetime of the network. The hybrid golden circle inspired optimization (HGCIO) is considered for cluster head (CH) selection, which aids in selecting the CH. The CH selection is done based on fitness functions like distance, energy, link quality, and delay. The routing is implemented with HGCIO to transmit the data projections using the CH to sink and evenly disperse the energy amidst various nodes. After that, compressive sensing is implemented with the Bayesian linear model. The convolutional neural network‐long short term memory (CNN‐LSTM) is employed for the data aggregation process. The proposed HGCIO‐based CNN‐LSTM provided the finest efficiency with a delay of 0.156 s, an energy of 0.353 J, a prediction error of 0.044, and a packet delivery ratio (PDR) of 76.309%.
Diagnostic and therapeutic strategies for colorectal tumor with positive muscle‐retracting sign
Authors: Tanaka Hidenori , Takehara Yudai , Morimoto Shin , Tanino Fumiaki , Yamamoto Noriko , Kamigaichi Yuki , Tsuboi Akiyoshi , Yamashita Ken , Kotachi Takahiro , Arihiro Koji , Oka Shiro 
Published: July 2023

AbstractObjectivesEndoscopic submucosal dissection (ESD) for colorectal tumors with positive muscle‐retracting (MR) sign often results in incomplete resection or discontinuation owing to the difficulty of submucosal dissection. The present study aimed to evaluate the usefulness of endoscopic ultrasonography (EUS) in diagnosing the MR sign and performing ESD using the pocket‐creation method (PCM).MethodsThirty‐six cases of colorectal tumors with positive MR sign during ESD between January 2015 and December 2021 were retrospectively reviewed. Cases were divided into two groups: 1) the conventional method (CM) group, comprising 29 cases, and 2) the PCM group with seven cases, in which preoperative EUS and ESD using PCM were performed. Treatment outcomes were compared between the groups. The diagnostic yield of EUS for the MR sign was evaluated among large sessile tumors >20 mm in which preoperative EUS was performed.ResultsHistologic diagnosis was adenoma or Tis carcinoma in 12 cases (33%), T1 carcinoma in 18 cases (50%), T2 carcinoma in four cases (11%), and unevaluable in two cases (6%). The sensitivity and specificity of the EUS‐MR sign for large sessile tumors were 87.5% and 83.3%, respectively. ESD was achieved in all cases in the PCM group, although it was discontinued in eight cases (28%) in the CM group. There were significant differences between the PCM and CM groups in en bloc resection (100% vs. 48%, p = 0.013) and R0 resection rates (71% vs. 31%, p = 0.049).ConclusionThe MR sign can be predicted by preoperative EUS, and ESD using PCM allows en bloc resection.
Waterfowl show spatiotemporal trends in influenza A H5 and H7 infections but limited taxonomic variation
Authors: Kent Cody M. , Bevins Sarah N. , Mullinax Jennifer M. , Sullivan Jeffery D. , Prosser Diann J. 
Published: July 2023

AbstractInfluenza A viruses in wild birds pose threats to the poultry industry, wild birds, and human health under certain conditions. Of particular importance are wild waterfowl, which are the primary reservoir of low‐pathogenicity influenza viruses that ultimately cause high‐pathogenicity outbreaks in poultry farms. Despite much work on the drivers of influenza A virus prevalence, the underlying viral subtype dynamics are still mostly unexplored. Nevertheless, understanding these dynamics, particularly for the agriculturally significant H5 and H7 subtypes, is important for mitigating the risk of outbreaks in domestic poultry farms. Here, using an expansive surveillance database, we take a large‐scale look at the spatial, temporal, and taxonomic drivers in the prevalence of these two subtypes among influenza A‐positive wild waterfowl. We document spatiotemporal trends that are consistent with past work, particularly an uptick in H5 viruses in late autumn and H7 viruses in spring. Interestingly, despite large species differences in temporal trends in overall influenza A virus prevalence, we document only modest differences in the relative abundance of these two subtypes and little, if any, temporal differences among species. As such, it appears that differences in species' phenology, physiology, and behaviors that influence overall susceptibility to influenza A viruses play a much lesser role in relative susceptibility to different subtypes. Instead, species are likely to freely pass viruses among each other regardless of subtype. Importantly, despite the similarities among species documented here, individual species still may play important roles in moving viruses across large geographic areas or sustaining local outbreaks through their different migratory behaviors.
Solving the stochastic dynamics of population growth
Authors: Marrec Loïc , Bank Claudia , Bertrand Thibault 
Published: July 2023

AbstractPopulation growth is a fundamental process in ecology and evolution. The population size dynamics during growth are often described by deterministic equations derived from kinetic models. Here, we simulate several population growth models and compare the size averaged over many stochastic realizations with the deterministic predictions. We show that these deterministic equations are generically bad predictors of the average stochastic population dynamics. Specifically, deterministic predictions overestimate the simulated population sizes, especially those of populations starting with a small number of individuals. Describing population growth as a stochastic birth process, we prove that the discrepancy between deterministic predictions and simulated data is due to unclosed‐moment dynamics. In other words, the deterministic approach does not consider the variability of birth times, which is particularly important with small population sizes. We show that some moment‐closure approximations describe the growth dynamics better than the deterministic prediction. However, they do not reduce the error satisfactorily and only apply to some population growth models. We explicitly solve the stochastic growth dynamics, and our solution applies to any population growth model. We show that our solution exactly quantifies the dynamics of a community composed of different strains and correctly predicts the fixation probability of a strain in a serial dilution experiment. Our work sets the foundations for a more faithful modeling of community and population dynamics. It will allow the development of new tools for a more accurate analysis of experimental and empirical results, including the inference of important growth parameters.