bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical retrieval of an embolized patent ductus arteriosus closure device in an infant weighing 1050 G
Authors: Selcuk Arif , Bishnoi Arvind Kumar , Kanter Joshua , Yerebakan Can 
Published: September 2023

Abstract
The dislodgement of device during transcatheter procedure is a rare complication and the device can be retrieved by transcatheter techniques in most cases. In case of failed attempts, the surgery may be required and in haemodynamically unstable patients cardiopulmonary bypass (CPB) may be unavoidable. A case of surgical retrieving of patent ductus arteriosus (PDA) occlusion device (OD) from the right pulmonary artery (PA) in a 1050 g baby on CPB was presented. In literature, CPB use in babies weighing under 1 kg has been rarely reported. CPB support was performed securely in our case who is one of the tiniest patients operated on. CPB can be safe enough in the surgical approach of a complication of very low birth weight patient.
Tight Complexes Are Golod
Authors: Iriye Kouyemon , Kishimoto Daisuke 
Published: September 2023

Abstract
Golodness of a simplicial complex is defined algebraically in terms of the Stanley–Reisner ring, and it has been a long-standing problem to find its combinatorial characterization. Tightness of a simplicial complex is a combinatorial analogue of a tight embedding of a manifold into Euclidean space, and has been studied in connection to minimal manifold triangulations. In this paper, by using an idea from toric topology, we prove that tight complexes are Golod, and as a corollary, we obtain that a triangulation of a closed connected orientable manifold is Golod if and only if it is tight, which is a combinatorial characterization of Golodness for manifold triangulations.
Lessons Learned From Global Hepatitis C Elimination Programs
Authors: Handanagic Senad , Shadaker Shaun , Drobeniuc Jan , Tsereteli Maia , Alkhazashvili Maia , Adesigbin Clement , Adamu Ibrahim , Adabe Ruth , Agwuocha Chukwuemeka , Adisa Olayinka , Azania Amy , Boeke Caroline E , Ngwije Alida , Serumondo Janvier , Armstrong Paige A 
Published: September 2023

Abstract
In 2016, the World Health Organization introduced global targets for the care and management of hepatitis C virus (HCV) infection to eliminate hepatitis C as a public health threat by 2030. Despite significant improvements in testing and treatment, in 2020 only 23% of all persons infected with HCV globally were diagnosed. We explore examples from global hepatitis C programs in Georgia, Rwanda, and Nigeria that have used decentralized and integrated models to increase access to HCV testing. Georgia established the world's first national hepatitis C elimination program in 2015. In 2022, 2.6 million people (80% of the adults) have been screened for antibodies for HCV infection, and 80 000 persons with HCV RNA detected were treated. To achieve these results, Georgia implemented HCV core antigen testing, utilization of point-of-care (POC) HCV RNA testing, and simplification of HCV viremia detection by qualitative HCV RNA testing. Rwanda was the first country in sub-Saharan Africa to commit to HCV elimination in 2018, and as of 2022 it has achieved its screening target of 7 million people and initiated approximately 60 000 patients on hepatitis C treatment by rapid decentralization and integration of HCV services. In Nigeria, the integrated near-POC testing approach in Nasarawa State has been effective in expanding access to HCV viremia testing and enabling the possibility of same-day testing and treatment initiation. Examples of decentralization and integration of HCV testing and linkage to care in Georgia, Rwanda, and Nigeria could help inform effective strategies to reach 2030 hepatitis C elimination goals in other countries.
Opportunities for Enhanced Prevention and Control of Hepatitis C Through Improved Screening and Testing Efforts
Authors: Cartwright Emily J , Patel Priti R 
Published: September 2023

Abstract
An estimated 2.4 million people in the United States are living with hepatitis C virus (HCV) infection. In 2020, the Centers for Disease Control and Prevention updated hepatitis C screening recommendations to test adults aged ≥18 years at least once in a lifetime and pregnant persons during each pregnancy. For those with ongoing exposure to HCV, periodic testing is recommended. The recommended testing sequence is to obtain an HCV antibody test and, when positive, perform an HCV RNA test. Examination of HCV care cascades has found that incomplete HCV testing occurs when a separate visit is required to obtain the HCV RNA test. Hepatitis C core antigen testing has been shown to be a useful tool for diagnosing current HCV infection in some settings. Hepatitis C testing that is completed, accurate, and efficient is necessary to achieve hepatitis C elimination goals.
Ferrets as a Mammalian Model to Study Influenza Virus-Bacteria Interactions
Authors: Basu Thakur Poulami , Mrotz Victoria J , Maines Taronna R , Belser Jessica A 
Published: September 2023

Abstract
Ferrets represent an invaluable model for the study of influenza virus pathogenicity and transmissibility. Ferrets are also employed for the study of bacterial pathogens that naturally infect humans at different anatomical sites. While viral and bacterial infection studies in isolation using animal models are important for furthering our understanding of pathogen biology and developing improved therapeutics, it is also critical to extend our knowledge to pathogen coinfections in vivo, to more closely examine interkingdom dynamics that may contribute to overall disease outcomes. We discuss how ferrets have been employed to study a diverse range of both influenza viruses and bacterial species and summarize key studies that have utilized the ferret model for primary influenza virus challenge followed by secondary bacterial infection. These copathogenesis studies have provided critical insight into the dynamic interplay between these pathogens, underscoring the utility of ferrets as a model system for investigating influenza virus-bacteria interactions.
High-Resolution Plasma Metabolomics Identifies Alterations in Fatty Acid, Energy, and Micronutrient Metabolism in Adults Across the Leprosy Spectrum
Authors: Fairley Jessica K , Ferreira José A , Fraga Lucia A O , Lyon Sandra , Valadão Cardoso Thales M , Boson Victor Campos , Madureira Nunes Ana Carolina , Medeiros Cinha Eloisa H , de Oliveira Lorena B P , Magueta Silva Erica B , Marçal Pedro H F , Branco Alexandre C , Grossi Maria Aparecida F , Jones Dean P , Ziegler Thomas R , Collins Jeffrey M 
Published: September 2023

Abstract

Background
High-resolution metabolomics (HRM) is an innovative tool to study challenging infectious diseases like leprosy, where the pathogen cannot be grown with standard methods. Here, we use HRM to better understand associations between disease manifestations, nutrition, and host metabolism.

Methods
From 2018 to 2019, adults with leprosy and controls were recruited in Minas Gerais, Brazil. Plasma metabolites were detected using an established HRM workflow and characterized by accurate mass, mass to charge ratio m/z and retention time. The mummichog informatics package compared metabolic pathways between cases and controls and between multibacillary (MB) and paucibacillary (PB) leprosy. Additionally, select individual metabolites were quantified and compared.

Results
Thirty-nine cases (62% MB and 38% PB) and 25 controls were enrolled. We found differences (P &lt; .05) in several metabolic pathways, including fatty acid metabolism, carnitine shuttle, retinol, vitamin D3, and C-21 steroid metabolism, between cases and controls with lower retinol and associated metabolites in cases. Between MB and PB, leukotrienes, prostaglandins, tryptophan, and cortisol were all found to be lower in MB (P &lt; .05).

Discussion
Metabolites associated with several nutrient-related metabolic pathways appeared differentially regulated in leprosy, especially MB versus PB. This pilot study demonstrates the metabolic interdependency of these pathways, which may play a role in the pathophysiology of disease.
Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell–Depleting Agents
Authors: Fernández-Ruiz Mario , García-Ríos Estéfani , Redondo Natalia , Rodríguez-Goncer Isabel , Ruiz-Merlo Tamara , Parra Patricia , Sandonis Virginia , López-Medrano Francisco , San Juan Rafael , González Esther , Polanco Natalia , Andrés Amado , Navarro David , Aguado José María , Pérez-Romero Pilar 
Published: September 2023

Abstract
We measured cytomegalovirus (CMV)-specific antibodies that neutralize epithelial cell infection (CMV-AbNEIs) in 101 CMV-seropositive kidney transplant recipients (KTRs) at baseline and posttransplant months 3 and 6. All the patients received antithymocyte globulin and 3-month valganciclovir prophylaxis. There were no significant differences in pretransplant AbNEIs titers between KTRs that developed or did not develop any-level CMV infection or the composite of high-level infection and/or disease. One-year CMV infection-free survival was comparable between KTRs with or without pretransplant CMV-AbNEIs. No differences were observed by months 3 and 6. We observed no protective role for CMV-AbNEIs among CMV-seropositive KTRs undergoing T-cell–depleting induction.
What a Radiologist Needs to Know About Breast Pathology Processes
Authors: Cavallo Hom Katherine , Forton Camelia , Mau Brian , Johnson Monica , Pyle Chelsea 
Published: September 2023

Abstract
Optimal breast care requires a multidisciplinary and integrated approach, including appropriate processes and communication between the radiology and pathology departments. It is important for breast radiologists to have an understanding of the important events that occur between the time a percutaneous biopsy sample is obtained and the point at which the final pathology report is issued. This article reviews the essential processes from breast biopsy through to pathology diagnosis, including the general pathology workflow, tissue preparation, immunohistochemical staining, and pathologic reporting. Upon completion of this educational article, participants will have gained an understanding of the essential steps in the pathology workflow. This article will also highlight the important clinical information a radiologist should provide to the pathologist to ensure the most accurate and clinically relevant diagnosis. This clinical information includes the BI-RADS assessment category, the type of imaging finding that was targeted for biopsy (particularly when there are calcifications), the location of the targeted lesion relative to other findings, and other pertinent patient history.
Choosing Therapy for Moderate to Severe Crohn’s Disease
Authors: Irani Malcolm , Abraham Bincy 
Published: September 2023

Abstract
The availability of approved therapies for Crohn’s disease has significantly increased over the past decade. To choose the appropriate therapy for the patient, ideally head to head studies, and data on positioning could help the provider individualize the decision. Due to the paucity of head-to-head trial data, we turn to network meta-analysis and real-world studies to help guide our treatment choices. Ultimately, the best approach is to consider each patient on an individual basis, taking into consideration the characteristics of their disease, individual risk factors, extra-intestinal manifestations, co-morbid conditions, patient age, cost, and personal preferences. In this review, we summarize the evidence comparing biologic as well as small molecule therapies for the treatment of moderate-to-severe Crohn’s disease. We have summarized the evidence in relation to factors such as efficacy, fistulizing disease, pregnancy, infection risk, and co-existing conditions.
How Do Consumers React to Production Waste?
Authors: Xu Haiyue (Felix) , Bolton Lisa E 
Published: September 2023

Abstract
Production waste, or inefficiencies in product manufacturing, is a major contributor to environmental problems. Consider production waste in garment manufacturing—which has been criticized for wasteful use of natural resources (e.g., using excessive water and fabric) and wasteful disposal of resource residuals (e.g., discarding excessive wastewater and fabric scraps). The present research examines consumer reactions to production waste and its mitigation as a function of whether it is characterized in terms of resource use versus disposal. A series of seven studies (including field and secondary data) finds that (i) consumers are less sensitive to wasteful resource use than disposal due to lower perceptions of environmental harm; (ii) likewise, consumers are less sensitive to waste mitigation targeting resource use than disposal due to lower perceptions of environmental benefit; and (iii) these waste reaction differences are attenuated when resource scarcity or long-term orientation is heightened (which increases consumer sensitivity to resource use). Together, this research sheds light on how, why, and when consumers are averse to production waste, while providing guidance regarding interventions focused on fighting production waste and promoting sustainability.
Hyperintensional models for non-congruential modal logics
Authors: Pascucci Matteo , Sedlár Igor 
Published: September 2023

AbstractIn this work, we illustrate applications of a semantic framework for non-congruential modal logic based on hyperintensional models. We start by discussing some philosophical ideas behind the approach; in particular, the difference between the set of possible worlds in which a formula is true (its intension) and the semantic content of a formula (its hyperintension), which is captured in a rigorous way in hyperintensional models. Next, we rigorously specify the approach and provide a fundamental completeness theorem. Moreover, we analyse examples of non-congruential systems that can be semantically characterized within this framework in an elegant and modular way. Finally, we compare the proposed framework with some alternatives available in the literature. In the light of the results obtained, we argue that hyperintensional models constitute a basic, general and unifying semantic framework for (non-congruential) modal logic.
Analytical and numerical investigation on the effects of landslide acceleration in landslide-generated tsunamis
Authors: Lo Peter H-Y , Chan I-Chi 
Published: September 2023

Abstract
Submarine landslides are capable of causing locally catastrophic tsunamis. A landslide necessarily begins its motion by accelerating from a halt. However, the role of landslide acceleration on the tsunami generated by a landslide remains understudied. Assuming an idealized configuration, in this study we cast the landslide acceleration problem as an extension to the existing knowledge on landslide-generated tsunamis above a flat sea bottom. By using the Green’s function approach, we derived new analytical solutions for the tsunami generated by an accelerating submarine landslide. Consistent with the observations in existing studies, we found that a slower landslide acceleration results in a longer but smaller leading submarine landslide tsunami wave. Based on a large number of numerical simulations, empirical formulas were established to quantify the wave modification factors due to landslide acceleration. Combining existing analytical solutions and the newly determined empirical formulas, we assembled semi-analytical solutions that can be easily used to predict the characteristics of the tsunami generated by an accelerating submarine landslide.
Acute hematologic toxicity of radiation therapy – a comprehensive analysis and predictive nomogram
Authors: Takeda Kazuya , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Suzuki Yu , Kishida Keita , Omata So , Jingu Keiichi 
Published: September 2023

Abstract
To investigate radiation-induced cytopenia and establish predictive nomograms for hematological toxicity, we reviewed 3786 patients aged 18 or older who received radiation monotherapy between 2010 and 2021 for non-hematologic malignancies. We collected data on patient background, treatment content and hematologic toxicities for 12 weeks after the start of radiotherapy. The patients were randomly divided into training and test groups in 7:3 ratio. In the training group, we conducted ordered logistic regression analysis to identify predictive factors for neutropenia, lymphocytopenia, anemia and thrombocytopenia. Nomograms to predict Grade 2–4 cytopenia were generated and validated in the test group. Grade 3 or higher hematologic toxicities were observed in 9.7, 44.6, 8.3 and 3.1% of patients with neutropenia, lymphocytopenia, anemia and thrombocytopenia, respectively. We identified six factors for neutropenia grade, nine for lymphocytopenia grade and six for anemia grade with statistical significance. In the analysis of thrombocytopenia, the statistical model did not converge because of a small number of events. Nomograms were generated using factors with high predictive power. In evaluating the nomograms, we found high area under the receiver operating characteristic curve values (neutropenia; 0.75–0.85, lymphopenia; 0.89–0.91 and anemia; 0.85–0.86) in predicting Grade 2–4 cytopenia in the test group. We established predictive nomograms for neutropenia, leukocytopenia and anemia and demonstrated high reproducibility when validated in an independent cohort of patients.
Efficacy of online cognitive behavioral therapy for nonorganic erectile dysfunction in reproductive-age males during the COVID-19 pandemic: a randomized wait list–controlled trial
Authors: Han Mi , Wang Xiao , Yang Huajing , Wang Xiaofeng , Zhu Hong , Song Mengfan 
Published: September 2023

Abstract

Background
Previous research has documented the impact of the COVID-19 pandemic on male sexual and mental health. However, no prior study has evaluated the efficacy of online cognitive behavioral therapy (CBT) during the COVID-19 pandemic for treating nonorganic erectile dysfunction (ED) by improving negative emotions and self-esteem.

Aim
To test the efficacy of online CBT for nonorganic ED during the COVID-19 pandemic in Shanghai, China.

Methods
A randomized controlled trial was conducted during the COVID-19 pandemic. Paired t-tests and 1-way analysis of variance were used to analyze and compare erectile functioning, self-esteem, and emotional state between and within groups.

Outcomes
The main outcome measures included scores on the 5-item International Index of Erectile Function, Rosenberg Self-esteem Scale, 9-item Patient Health Questionnaire, and 7-item Generalized Anxiety Disorder scale to evaluate erectile functioning, self-esteem, depression, and anxiety, respectively.

Results
In the CBT group, erectile functioning, intercourse satisfaction, orgasmic functioning, sexual desire, and overall satisfaction were significantly improved at posttreatment as compared with pretreatment (P &lt; .05). After treatment, group differences in emotional state and self-esteem were observed between the CBT group and the control group. Results revealed that the CBT group had significantly better scores than the control group at posttreatment on the Rosenberg Self-esteem Scale (mean ± SD, 30.43 ± 6.51 vs 22.67 ± 10.74), Patient Health Questionnaire (7.07 ± 2.74 vs 11.07 ± 4.41), and Generalized Anxiety Disorder scale (8.36 ± 1.97 vs 11.13 ± 3.94; P &lt; .05).

Clinical Implications
This study represents an important advance in understanding of the efficacy of online CBT for treating nonorganic ED in reproductive-age males during the COVID-19 pandemic.

Strengths and Limitations
The study participants, treatment modality, and COVID-19 pandemic background of this study are innovative and therefore strengths. However, our study has several limitations—namely, its sample size and use of self-report data to measure erectile functioning due to the pandemic. Further studies should incorporate sexual functioning–monitoring instruments as well as self-report data to measure erectile function.

Conclusion
Online CBT clearly improved the emotional state and self-esteem of patients with ED during the COVID-19 pandemic.
Fibromyalgia syndrome is associated with sexual dysfunction regardless of physical activity status: a cross-sectional study
Authors: Mollà-Casanova Sara , Muñoz-Gómez Elena , Sempere-Rubio Núria , Inglés Marta , Aguilar-Rodríguez Marta , Moreno-Cervera Noelia , Serra-Añó Pilar 
Published: September 2023

Abstract

Background
Fibromyalgia syndrome (FMS) is a rheumatic disorder that has been observed to affect self-perception of sexuality.

Aim
The study aims to assess sexual dysfunction (SD), establish possible associations with SD levels, and evaluate the impact of physical activity (PA) levels on SD in Spanish women with FMS as compared with healthy control women.

Methods
The study was cross-sectional. A total of 170 women voluntarily agreed to participate between September 2019 and February 2020: 88 in the FMS group and 82 in the control group.

Outcomes
The main outcome measures were SD, as assessed through the Female Sexual Function Index (FSFI), and PA levels, as assessed with a structured interview.

Results
There were significant differences in every domain and total SD score between the FMS and control groups (P &lt; .05). In addition, we obtained a moderate significant direct association (χ2[1] = 37.071, P &lt; .05, phi = 0.467) when exploring the associations between FMS and risk of SD. Results showed statistically significant differences between the FMS group and the control group when PA levels were not reached in the desire, pain, and total scores of the FSFI (P &lt; .05). When the PA levels were reached, between-group differences were found in all domains, as well as in the total score of the FSFI (P &lt; .05).

Clinical Implications
Sexual function should be evaluated in women with FMS, while future treatments should address this clinical area with the aim of managing SD in this population.

Strengths and Limitations
The main limitation is that the outcome measures were self-reported.

Conclusion
We found a high prevalence of SD in Spanish women with FMS, with an impact on aspects such as desire, arousal, lubrication, orgasm, satisfaction, and pain during sexual intercourse. In addition, there is a moderate direct association between FMS and SD. Ultimately, the results showed that, irrespective of PA, women with FMS reported increased SD.
Grain yield trade-offs in spike-branching wheat can be mitigated by elite alleles affecting sink capacity and post-anthesis source activity
Authors: Abbai Ragavendran , Golan Guy , Longin C Friedrich H , Schnurbusch Thorsten 
Published: September 2023

Abstract
Introducing variations in inflorescence architecture, such as the ‘Miracle-Wheat’ (Triticum turgidum convar. compositum (L.f.) Filat.) with a branching spike, has relevance for enhancing wheat grain yield. However, in the spike-branching genotypes, the increase in spikelet number is generally not translated into grain yield advantage because of reduced grains per spikelet and grain weight. Here, we investigated if such trade-offs might be a function of source–sink strength by using 385 recombinant inbred lines developed by intercrossing the spike-branching landrace TRI 984 and CIRNO C2008, an elite durum (T. durum L.) cultivar; they were genotyped using the 25K array. Various plant and spike architectural traits, including flag leaf, peduncle, and spike senescence rate, were phenotyped under field conditions for 2 consecutive years. On chromosome 5AL, we found a new modifier QTL for spike branching, branched headt3 (bht-A3), which was epistatic to the previously known bht-A1 locus. Besides, bht-A3 was associated with more grains per spikelet and a delay in flag leaf senescence rate. Importantly, favourable alleles, viz. bht-A3 and grain protein content (gpc-B1) that delayed senescence, are required to improve grain number and grain weight in the spike-branching genotypes. In summary, achieving a balanced source–sink relationship might minimize grain yield trade-offs in Miracle-Wheat.