bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mHz quasi-regular modulations of 4U 1630−47 during its 1998 outburst
Authors: Zhao Q C , Yin H X , Tao L , Yang Z X , Qu J L , Zhang L , Zhang S , Qiao E L , Bu Q C , Zhao S J , Li P P , Huang Y M , Ma R C , Tang R J , Jin P , Yu W , Liu H X , Huang Y , Ma X , Xiao J Y , Zhang X , Zhao K 
Published: June 2023

ABSTRACT
We present the results of a detailed timing and spectral analysis of the quasi-regular modulation (QRM) phenomenon in the black hole X-ray binary 4U 1630−47 during its 1998 outburst observed by the Rossi X-ray Timing Explorer (RXTE). We find that the ∼50–110 mHz QRM is flux dependent, and the QRM is detected with simultaneous low-frequency quasi-periodic oscillations (LFQPOs). According to the behaviour of the power density spectrum, we divide the observations into four groups. In the first group, namely behaviour A, LFQPOs are detected, but no mHz QRM. The second group, namely behaviour B, a QRM with frequency above ∼88 mHz is detected and the ∼5 and ∼7 Hz LFQPOs are almost overlapping. In the third group, namely behaviour C, the QRM frequency below ∼88 mHz is detected and the LFQPOs are significantly separated. In the fourth group, namely behaviour D, neither QRM nor LFQPOs are detected. We study the energy dependence of the fractional rms, centroid frequency, and phase lag of QRM and LFQPOs for behaviour B and C. We then study the evolution of QRM and find that the frequency of QRM increases with hardness, while its rms decreases with hardness. We also analyse the spectra of each observation, and find that the QRM rms of behaviour B has a positive correlation with $F_{\rm power\ law}$/$F_{\rm total}$. Finally, we give our understanding for this mHz QRM phenomenon.
Second-generation protoplanetary discs around evolved binaries: a high-resolution polarimetric view with SPHERE/IRDIS
Authors: Andrych Kateryna , Kamath Devika , Kluska Jacques , Van Winckel Hans , Ertel Steve , Corporaal Akke 
Published: June 2023

ABSTRACT
Binary post-asymptotic giant branch (post-AGB) stars are products of a poorly understood binary interaction process that occurs during the AGB phase. These systems comprise a post-AGB primary star, a main-sequence secondary companion and a stable circumbinary disc. Studying the structure and properties of these circumbinary discs is crucial for gaining insight into the binary interaction process that governs post-AGB binaries as well as comprehending the disc’s creation, evolution, and its interaction with the post-AGB binary system. We aim to use near-infrared polarimetric imaging to investigate the morphology and potential substructures of circumbinary discs around eight representative post-AGB binary stars. To achieve this, we performed polarimetric differential imaging in H and Y bands using the high-angular resolution capabilities of the European Southern Observatory-Very Large Telescope/SPHERE-Infra-Red Dual-beam Imaging and Spectroscopy instrument. We resolved the extended circumbinary disc structure for a diverse sample of eight post-AGB binary systems. Our analysis provided the first estimates of the disc scale height for two of the systems: IW Car and IRAS 15469–5311. We also investigated the morphological differences between the full discs (with the inner rim at the dust sublimation radius) and transition discs (which are expected to have larger inner cavities), as well as similarities to protoplanetary discs around young stellar objects. We found that the transition discs displayed a more intricate and asymmetric configuration. Surprisingly, no correlation was found between the overresolved flux in near-infrared interferometric data and the polarimetric observations, suggesting that scattering of light on the disc surface may not be the primary cause of the observed overresolved flux component.
Emerging Roles of FHY3 and FAR1 as System Integrators in Plant Development
Authors: Zheng Yanyan , Sun Yanzhao , Liu Yang 
Published: June 2023

Abstract
FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED-IMPAIRED RESPONSE1 (FAR1) are transcription factors derived from transposases essential for phytochrome A–mediated light signaling. In addition to their essential role in light signaling, FHY3 and FAR1 also play diverse regulatory roles in plant growth and development, including clock entrainment, seed dormancy and germination, senescence, chloroplast formation, branching, flowering and meristem development. Notably, accumulating evidence indicates that the emerging role of FHY3 and FAR1 in environmental stress signaling has begun to be revealed. In this review, we summarize these recent findings in the context of FHY3 and FAR1 as integrators of light and other developmental and stressful signals. We also discuss the antagonistic action of FHY3/FAR1 and Phytochrome Interating Factors (PIFs) in various cross-talks between light, hormone and environmental cues.
CONSTANS interacts with and antagonizes ABF transcription factors during salt stress under long-day conditions
Authors: Du Jiancan , Zhu Xiang , He Kunrong , Kui Mengyi , Zhang Juping , Han Xiao , Fu Qiantang , Jiang Yanjuan , Hu Yanru 
Published: June 2023

Abstract
CONSTANS (CO) is a critical regulator of flowering that combines photoperiodic and circadian signals in Arabidopsis (Arabidopsis thaliana). CO is expressed in multiple tissues, including seedling roots and young leaves. However, the roles and underlying mechanisms of CO in modulating physiological processes outside of flowering remain obscure. Here, we show that the expression of CO responds to salinity treatment. CO negatively mediated salinity tolerance under long-day (LD) conditions. Seedlings from co-mutants were more tolerant to salinity stress, whereas overexpression of CO resulted in plants with reduced tolerance to salinity stress. Further genetic analyses revealed the negative involvement of GIGANTEA (GI) in salinity tolerance requires a functional CO. Mechanistic analysis demonstrated that CO physically interacts with 4 critical basic leucine zipper (bZIP) transcription factors; ABSCISIC ACID-RESPONSIVE ELEMENT BINDING FACTOR1 (ABF1), ABF2, ABF3, and ABF4. Disrupting these ABFs made plants hypersensitive to salinity stress, demonstrating that ABFs enhance salinity tolerance. Moreover, ABF mutations largely rescued the salinity-tolerant phenotype of co-mutants. CO suppresses the expression of several salinity-responsive genes and influences the transcriptional regulation function of ABF3. Collectively, our results show that the LD-induced CO works antagonistically with ABFs to modulate salinity responses, thus revealing how CO negatively regulates plant adaptation to salinity stress.
Oxytocinergic modulation of speech production—a double-blind placebo-controlled fMRI study
Authors: Vogt Charlotte , Floegel Mareike , Kasper Johannes , Gispert-Sánchez Suzana , Kell Christian A 
Published: June 2023

Abstract
Many socio-affective behaviors, such as speech, are modulated by oxytocin. While oxytocin modulates speech perception, it is not known whether it also affects speech production. Here, we investigated effects of oxytocin administration and interactions with the functional rs53576 oxytocin receptor (OXTR) polymorphism on produced speech and its underlying brain activity. During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline. Participants were studied once under the influence of intranasal oxytocin and in another session under placebo. Oxytocin administration increased the second formant of produced vowels. This acoustic feature has previously been associated with speech valence; however, the acoustic differences were not perceptually distinguishable in our experimental setting. When preparing to speak, oxytocin enhanced brain activity in sensorimotor cortices and regions of both dorsal and right ventral speech processing streams, as well as subcortical and cortical limbic and executive control regions. In some of these regions, the rs53576 OXTR polymorphism modulated oxytocin administration–related brain activity. Oxytocin also gated cortical-basal ganglia circuits involved in the generation of happy prosody. Our findings suggest that several neural processes underlying speech production are modulated by oxytocin, including control of not only affective intonation but also sensorimotor aspects during emotionally neutral speech.
Financial Health of Local Governments: A Gender Approach
Authors: Guillamón María-Dolores , Ríos Ana-María , Cuadrado-Ballesteros Beatriz 
Published: June 2023

Abstract
In recent years, public sector research has developed a line related to women’s participation in government and its effect on public finances. In this vein, this article attempts to empirically analyze the effect women’s presence in local governments has on municipal financial health. For that, we use a sample of the 140 Spanish municipalities with more than 50,000 inhabitants during the period 2008–2018 and we create four indicators that refer to cash, budgetary and service-level solvency, as well as a global index that represents the municipal financial health. Our empirical results show that municipalities with a female mayor and with higher percentages of women in the council tend to have higher levels of these ratios. This supports the view that the entrance of women into the traditionally male-dominated public sphere could benefit governments’ financial health.
Results of a National Survey on the Definition of Surgical Site Infections After Mohs Micrographic Surgery
Authors: Hanly Ailish M. , Daniel Vijaya T. , Mahmoud Bassel H. 
Published: June 2023

BACKGROUND
There is no standardized definition of surgical site infections (SSI) after Mohs micrographic surgery (MMS) used in the clinical or research settings, which may contribute to heterogeneity in the differences in infection rates reported.

OBJECTIVE
To use an electronic survey of Mohs surgeons across the country to better understand how Mohs surgeons define SSI after MMS.

METHODS
A web-based survey was developed and distributed to Mohs surgeons. Respondents were asked to respond to several different scenarios that could represent SSI after MMS.

RESULTS
Of potential 1,500 respondents, 79 (5.3%) responded to the survey. Presentation of a surgical site with warmth, swelling, erythema, and pain at 7 days postoperatively resulted in 79.7% consensus of SSI. Surgical sites that were cultured and found to be Staphylococcus aureus-positive resulted in 100% agreement of SSI. There was no consensus regarding timing after MMS.

CONCLUSION
There is consensus on numerous aspects of SSI after MMS among Mohs surgeons, which may allow for development of standardized definition in the future.
Unanswered questions on coronary artery graft patency and clinical outcomes
Authors: Harik Lamia , Sandner Sigrid , Gaudino Mario 
Published: June 2023

Purpose of review
To review current issues related to coronary artery graft patency and outcomes.

Recent findings
The association of coronary artery graft patency with clinical outcomes is a traditional concept; however, it has been challenged by the results of numerous studies. Key limitations of the existing evidence include the lack of a universal definition of graft failure, the absence of systematic imaging in contemporary coronary artery bypass grafting trials, the reliance on observational data with inherent selection and survival bias, and high attrition rates for follow-up imaging. Key modulators of graft failure, and of the relationship between graft failure and outcomes, include the type of conduit and myocardial territory grafted, conduit harvesting technique, and postoperative antithrombotic regimen and patient sex.

Summary
The relationship between graft failure and clinical events is complex and variable. Overall, the preponderance of current data suggests a possible association between graft failure and nonfatal clinical events.
Monitoring treatment with cardiac myosin inhibitors in symptomatic obstructive hypertrophic cardiomyopathy
Authors: Chatur Safia , Hegde Sheila M. 
Published: June 2023

Purpose of review
Cardiac myosin inhibitors (CMIs) represent a major milestone in the treatment of patients with symptomatic obstructive hypertrophic cardiomyopathy. The objective of this review is to discuss the mechanisms of action, clinical trial evidence, safety profile and monitoring of CMIs, which are important to the implementation of these drugs in clinical practice.

Recent findings
Mavacamten and aficamten have both been shown to substantially improve left ventricular outflow tract gradients, biomarkers and symptoms in patients with obstructive hypertrophic cardiomyopathy. Both agents are well tolerated with few adverse events in clinical trial follow up. Transient reductions in left ventricular ejection fraction may be associated with both mavacamten and aficamten but respond to dose reduction.

Summary
There is now robust clinical trial evidence base to support the use of mavacamten for patients with symptomatic obstructive hypertrophic cardiomyopathy. Generation of long-term safety and efficacy data and exploring applications of CMI to nonobstructive cardiomyopathy and heart failure with preserved ejection fraction represent important next steps.
First-trimester serum antiphosphatidylserine antibodies serve as candidate biomarkers for predicting pregnancy-induced hypertension
Authors: Li Yan , Niu Yue , Liu Mingxi , Lan Xiangxin , Qin Rencai , Ma Kongyang , Zhao Hong-Jin 
Published: June 2023

Objective:
The aim of this study was to explore whether antiphosphatidylserine (aPS) antibodies play roles in the early prediction of pregnancy-induced hypertension (PIH).

Methods:
The serum levels of different isotypes of aPS antibodies were compared in women diagnosed with PIH (PIH group, n = 30) and 1 : 1 matched normotensive controls (control group, n = 30). All patients underwent frozen embryo transfer (FET) cycles, and all serum samples were collected during 11–13 weeks of gestation. Receiver operating characteristic (ROC) curves were drawn to analyze the predictive values of aPS antibodies for PIH.

Results:
The women who developed PIH after FET had higher serum optical density values (450 nm) of aPS immunoglobulin (Ig) A (1.31 ± 0.43 vs. 1.02 ± 0.51, P = 0.022), aPS IgM (1.00 ± 0.34 vs. 0.87 ± 0.18, P = 0.046), and aPS IgG (0.50 ± 0.12 vs. 0.34 ± 0.07, P < 0.001) compared with the normotensive controls. The serum concentration of total IgG [48.29 ± 10.71 (g/dl) vs. 34.39 ± 11.62 (g/dl), P < 0.001] was also higher in the PIH group compared with that in the control group. The aPS IgG alone [area under the curve (AUC): 0.913, 95% confidence interval (CI): 0.842–0.985, P < 0.001] and the combined analysis of aPS IgA, aPS IgM, aPS IgG, and total IgG (AUC: 0.944, 95% CI: 0.888–1.000, P < 0.001) had high predictive values for PIH.

Conclusion:
Serum aPS autoantibody levels during the first trimester of pregnancy are positively associated with the development of PIH. Further validation is needed to clearly identify the distinct contributions and underlying mechanisms for diagnostic applications of aPS autoantibodies in PIH prediction.
Development of a Model to Identify Febrile Children at Low Risk for Multisystem Inflammatory Syndrome
Authors: Lubell Tamar R. , Gorelik Mark , Abel Dori , Fischer Avital M. , Apfel Gabriel , Ryan Katherine , Wang Tian , Anderson Brett R. , Farooqi Kanwal M. , Dayan Peter S. 
Published: June 2023

Objectives
The case definition for multisystem inflammatory syndrome in children (MIS-C) is broad and encompasses symptoms and signs commonly seen in children with fever. Our aim was to identify clinical predictors that, independently or in combination, identify febrile children presenting to the emergency department (ED) as low risk for MIS-C.

Methods
We conducted a retrospective single-center study of otherwise healthy children 2 months to 20 years of age presenting to the ED with fever and who had a laboratory evaluation for MIS-C between April 15, 2020, and October 31, 2020. We excluded children with a diagnosis of Kawasaki disease. Our outcome was an MIS-C diagnosis defined by the Centers for Disease Control and Prevention criteria. We conducted multivariable logistic regression analyses to identify variables independently associated with MIS-C.

Results
Thirty-three patients with and 128 patients without MIS-C were analyzed. Of those with MIS-C, 16 of 33 (48.5%) had hypotension for age, signs of hypoperfusion, or required ionotropic support. Four variables were independently associated with the presence of MIS-C; known or suspected SARS CoV-2 exposure (adjusted odds ratio [aOR], 4.0; 95% confidence interval [CI], 1.4–11.9) and the following 3 symptoms and signs: abdominal pain on history (aOR, 4.8; 95% CI, 1.7–15.0), conjunctival injection (aOR, 15.2; 95% CI, 5.4–48.1), and rash involving the palms or soles (aOR, 12.2; 95% CI, 2.4–69.4). Children were at low risk of MIS-C if none of the 3 symptoms or signs were present (sensitivity 87.9% [95% CI, 71.8–96.6]; specificity 62.5% [53.5–70.9], negative predictive value 95.2% [88.3–98.7]). Of the 4 MIS-C patients without any of these 3 factors, 2 were ill-appearing in the ED and the other 2 had no cardiovascular involvement during their clinical course.

Conclusions
A combination of 3 clinical symptoms and signs had moderate to high sensitivity and high negative predictive value for identifying febrile children at low risk of MIS-C. If validated, these factors could aid clinicians in determining the need to obtain or forego an MIS-C laboratory evaluation during SARS-CoV-2 prevalent periods in febrile children.
Median and Ulnar Nerve Compressions: Simplifying Diagnostics and Surgery at the Elbow and Hand
Authors: Hagert Elisabet , Curtin Catherine 
Published: June 2023

Learning Objectives:
After studying this article, the participant should be able to: 1. Understand the anatomy of the median and ulnar nerves. 2. Perform clinical examination of the upper limb. 3. Analyze examination results to diagnose level of nerve compression.

Summary:
Numbness and loss of strength are common complaints in the hand surgery clinic. Two nerves that are commonly entrapped (median and ulnar nerves) have several potential sites of entrapment, and in busy clinical practice, the less common sites may be overlooked, leading to wrong or missed diagnoses. This article reviews the anatomy of the median and ulnar nerves, provides tips to assist the busy clinician in diagnosis of site of entrapment(s), and discusses how to simplify surgery. The goal is to help the clinician be as efficient and accurate as possible when evaluating the patient with numbness or loss of strength in their hand.
Novel Diagnostic Imaging Approach for Patients With Spontaneous Coronary Artery Dissection
Authors: Safiullah Zaid N. , Latina Jacqueline M. , Ziogos Efthymios , Harb Tarek , Schindler Thomas H. , Valenta-Schindler Ines , Alavi Abass , Gerstenblith Gary , Leucker Thorsten M. 
Published: June 2023

Abstract
Spontaneous coronary artery dissection (SCAD) is an underdiagnosed etiology of acute coronary syndrome in women. Accurate diagnosis remains challenging but is imperative for treatment and prevention. We show here the utility of 18F-FDG PET imaging in SCAD diagnosis. We present 1 representative case of 4 women with suspected SCAD on coronary angiography from the EVACS (Evolocumab in Acute Coronary Syndromes) clinical trial. 18F-FDG PET imaging showed acute inflammation in the distribution of the suspected dissected coronary artery identified on angiography. Localized myocardial inflammation identified on 18F-FDG PET imaging can aid in diagnosing SCAD suspected on coronary angiography.
Synchronous Treatment of Breast Cancer Hepatic Metastases by Transarterial Radioembolization and Radiofrequency Thermoablation
Authors: Perrone Elisabetta , Moretti Roberto , Indovina Luca , Iezzi Roberto , Zagaria Luca 
Published: June 2023

Abstract
In a 51-year-old woman affected by breast cancer, hepatic recurrence of disease was managed by concurrent 90Y-labeled glass microsphere embolization (transarterial radioembolization) and radiofrequency thermoablation. Intention-to-treat target, candidate to radioembolization, was in the IV hepatic segment; another lesion, managed with radiofrequency thermoablation, was in the VI–VII hepatic segment. Concomitant correction of a duodenocephalopancreatic shunting was performed as well. Thermoablation did not interfere with distribution of 99mTc–macroaggregated albumin and 90Y-labeled microspheres to the target and healthy liver. At our knowledge, this is the first report that combines 2 locoregional procedures in different hepatic segments on the same day.
Promises and pitfalls of imaging-based biomarkers in motor neuron diseases
Authors: Tan Ee Ling , Bede Peter , Pradat Pierre-Francois 
Published: June 2023

Purpose of review
Although neuroimaging in motor neuron diseases (MNDs) continues to generate important novel academic insights, the translation of novel radiological protocols into viable biomarkers remains challenging.

Recent findings
A multitude of technological advances contribute to the success of academic imaging in MND such as the availability of high-field MRI platforms, novel imaging techniques, quantitative spinal cord protocols to whole-brain spectroscopy. International collaborations, protocol harmonization efforts, open-source image analysis suites also fuel developments in the field. Despite the success of academic neuroimaging in MND, the meaningful interpretation of radiological data from single patients and accurate classification into relevant diagnostic, phenotypic and prognostic categories remain challenging. Appraising accruing disease burden over the short follow-up intervals typically used in pharmacological trials is also notoriously difficult.

Summary
Although we acknowledge the academic achievements of large descriptive studies, an unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic and monitoring applications to meet the practical demands of clinical decision-making and pharmacological trials. A paradigm shift from group-level analyses to individual-level data interpretation, accurate single-subject classification and disease-burden tracking is therefore urgently needed to distil raw spatially coded imaging data into practical biomarkers.
Predicting cognitive decline in older people by structural and molecular imaging
Authors: Teipel Stefan , Tang Yi , Boccardi Marina 
Published: June 2023

Purpose of review
Availability of possible disease modifying treatments and the recognition of predementia stages of Alzheimer's disease (AD) have raised awareness for the prognostic and predictive role of biomarkers, particularly imaging markers.

Recent findings
The positive predictive value of amyloid PET for the transition to prodromal AD or AD dementia in cognitively normal people is below 25%. Evidence for tau PET, FDG-PET and structural MRI is even more limited. In people with mild cognitive impairment (MCI), imaging markers yield positive predictive values above 60% with moderate advantages for amyloid PET over the other modalities and an added value for the combination of molecular with downstream neurodegeneration markers.

Summary
In cognitively normal people, imaging is not recommended for individual prognosis due to lack of sufficient predictive accuracy. Such measures should be restricted to risk enrichment in clinical trials. In people with MCI, amyloid PET and, to a somewhat lesser extent, tau PET, FDG-PET, and MRI yield relevant predictive accuracy for clinical counseling as part of a comprehensive diagnostic program in tertiary care units. Future studies should focus on the systematic and patient-centered implementation of imaging markers in evidence-based care-pathways for people with prodromal AD.