bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ALL: A retrospective nationwide study
Authors: Hirabayashi Shigeki , Kondo Tadakazu , Nishiwaki Satoshi , Mizuta Shuichi , Doki Noriko , Fukuda Takahiro , Uchida Naoyuki , Ozawa Yukiyasu , Kanda Yoshinobu , Imanaka Ryota , Takahashi Satoshi , Ishikawa Jun , Yano Shingo , Nakamae Hirohisa , Eto Tetsuya , Kimura Takafumi , Tanaka Junji , Ichinohe Tatsuo , Atsuta Yoshiko , Kako Shinichi 
Published: July 2023

AbstractMeasurable residual disease (MRD) status before transplantation has been shown to be a strong prognostic factor in patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ ALL). However, the outcomes of unrelated hematopoietic stem cell transplantation based on the MRD status have not been fully investigated. In this retrospective study, we compared the outcomes of 715 consecutive adults with Ph+ ALL in complete remission who underwent unrelated cord blood transplantation (UCBT) (single‐unit UCBT, n = 232 [4/6, 5/6, and 6/6 HLA match]), HLA‐matched unrelated bone marrow transplantation (UBMT; n = 292 [8/8 HLA match]), or HLA‐mismatched UBMT (n = 191 [7/8 HLA match]). In the MRD+ cohort, adjusted 3‐year leukemia‐free survival rates were 59.8%, 38.3%, and 55.5% after UCBT, HLA‐matched UBMT, and HLA‐mismatched UBMT, respectively. In the MRD− cohort, the corresponding rates were 65.3%, 70.4%, and 69.7%, respectively. The MRD+ HLA‐matched UBMT group had a significantly higher risk of relapse than the MRD+ HLA‐mismatched UBMT group (hazard ratio [HR] in the MRD+ HLA‐mismatched UBMT group, 0.33; 95% confidence interval [CI] 0.15–0.74) and the MRD+ UCBT group (HR in the MRD+ UCBT group, 0.38; 95% CI 0.18–0.83). Furthermore, HLA‐matched UBMT had a significant effect of MRD on death (HR 1.87; 95% CI 1.19–2.94), relapse or death (HR 2.24; 95% CI 1.50–3.34), and relapse (HR 3.12; 95% CI 1.75–5.57), while UCBT and HLA‐mismatched UBMT did not. In conclusion, our data indicate Ph+ ALL patients with positive MRD may benefit from undergoing UCBT or HLA‐mismatched UBMT instead of HLA‐matched UBMT to reduce leukemic relapse.
Cerebrospinal fluid biomarkers in the Longitudinal Early‐onset Alzheimer's Disease Study
Authors: Dage Jeffrey L. , Eloyan Ani , Thangarajah Maryanne , Hammers Dustin B. , Fagan Anne M. , Gray Julia D. , Schindler Suzanne E. , Snoddy Casey , Nudelman Kelly N. H. , Faber Kelley M. , Foroud Tatiana , Aisen Paul , Griffin Percy , Grinberg Lea T. , Iaccarino Leonardo , Kirby Kala , Kramer Joel , Koeppe Robert , Kukull Walter A. , La Joie Renaud , Mundada Nidhi S , Murray Melissa E. , Rumbaugh Malia , Soleimani‐Meigooni David N. , Toga Arthur W. , Touroutoglou Alexandra , Vemuri Prashanthi , Atri Alireza , Beckett Laurel A. , Day Gregory S. , Graff‐Radford Neill R. , Duara Ranjan , Honig Lawrence S. , Jones David T. , Masdeu Joseph C. , Mendez Mario F. , Musiek Erik , Onyike Chiadi U. , Riddle Meghan , Rogalski Emily , Salloway Stephen , Sha Sharon J. , Turner Raymond S. , Wingo Thomas S. , Wolk David A. , Womack Kyle B. , Carrillo Maria C. , Dickerson Bradford C. , Rabinovici Gil D. , Apostolova Liana G. ,   LEADS Consortium
Published: July 2023

AbstractIntroductionOne goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early‐onset Alzheimer's disease (EOAD).MethodsCerebrospinal fluid (CSF) concentrations of Aβ1‐40, Aβ1‐42, total tau (tTau), pTau181, VILIP‐1, SNAP‐25, neurogranin (Ng), neurofilament light chain (NfL), and YKL‐40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated.ResultsBiomarkers were correlated with one another. Levels of CSF Aβ42/40, pTau181, tTau, SNAP‐25, and Ng in EOAD differed significantly from cognitively normal and early‐onset non‐AD dementia; NfL, YKL‐40, and VILIP‐1 did not. Across groups, all biomarkers except SNAP‐25 were correlated with cognition. Within the EOAD group, Aβ42/40, NfL, Ng, and SNAP‐25 were correlated with at least one cognitive measure.DiscussionThis study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.
Study of antifouling and decolorization effect in polyethersulfone membranes improved with dendrimer‐modified metal–organic frameworks
Authors: Khosravi Mohammad Javad , Hosseini Sayed Mohsen , Vatanpour Vahid , Heydari Shadi 
Published: July 2023

AbstractThe Mil‐125(Ti) metal–organic framework nanoparticles were modified with different compounds i.e. polyamidoamine dendrimer (Mil‐Den), chitosan (Mil‐CS) and Mil‐CS‐Den to prepare functional and hydrophilic nanocomposites. These nanocomposites were characterized and applied for modification of polyethersulfone (PES) membrane by blending them in the dope solutions. The mixed matrix PES membranes were manufactured by the nonsolvent‐induced phase inversion method. The introduction of the nanocomposites into the membrane structure led to positive alterations such as the improvement of hydrophilicity and morphology causing the development of permeability and antifouling properties. The bare PES membrane contact angle was decreased from 60° to 34.5° by adding 0.5 wt% of Mil‐CS‐Den nanocomposite. Applications of novel structures with special absorption in 0.5 wt% of Mil‐CS‐Den membrane, caused an increment of porosity, mean pore size and reduction of surface roughness. The permeability was enhanced from 4.2 to 21.43 L/m2 h bar, while fouling was reduced from 48.5% to 13.5% which indicates the strengthening of the antifouling feature of the hydrophobic PES membrane. Also, the flux recovery ratio was enhanced from 66.7% to 89.3% by blending 0.5 wt% of Mil‐CS‐Den. The modified membranes showed an excellent dye separation performance. The attachment of dendrimer and chitosan to the Mil‐125(Ti) surface increased the efficiency of Mil‐125(Ti) in the modification of the PES membrane. The utilization of nanomaterial features can reduce the limitation of membrane processes and reach desirable outcomes. The results of this work indicate the high potential of the modified MOF for the removal of dye contaminants as well as provide a suitable perspective for water purification with the help of membrane processes.
Antistatic and antimicrobial packaging ofPLA/PHBVblend‐based graphene nanoplatelets nanocomposites
Authors: Oyama Isabela Monteiro Cesar , dos Anjos Erick Gabriel Ribeiro , de Melo Morgado Guilherme Ferreira , Martins Eduardo Ferreira , Passador Fabio Roberto 
Published: July 2023

AbstractGraphene nanoplatelets (GNP) were used as a filler for the preparation of antistatic and antimicrobial packaging based on biodegradable blends of poly(acid lactic)/poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PLA/PHBV) for the electronic components industry. These packages must have low electrical resistivity and mechanical resistance. The use of biodegradable polymers helps to reduce waste and the addition of GNP can also contribute to antimicrobial activity. In this work, the effect of the addition of GNP on the thermal, mechanical, electrical, electromagnetic properties, and antimicrobial activity of the PLA/PHVB blend was evaluated. PLA/PHBV (80/20) blends with the addition of 1, 3, and 5 wt% of GNP were prepared by melt mixing using extrusion and injection‐mold processes. The samples were characterized by mechanical tests (tensile test, and Shore D hardness), thermal (differential scanning calorimetry and thermogravimetric analysis), impedance spectroscopy, electromagnetic interference shielding efficiency (EMI SE), antimicrobial activity, and field emission gun scanning electron microscopy. In general, the addition of GNP contributes to the increase in elastic modulus and Shore D hardness. The percolation threshold was obtained with the addition of 3 or 5 wt% of GNP in the PLA/PHBV blend with a reduction of 3 orders of magnitude in the electrical resistivity, which can be applied to antistatic packaging. All the nanocomposites exhibited antimicrobial activity, and the addition of 5 wt% GNP inhibited 86% of the growth ofEscherichia coli. The PLA/PHBV blend‐based GNP nanocomposite with the addition of 5 wt% of GNP presents the best balance of mechanical properties, with low electrical resistivity, greater total shielding effectiveness of EMI SE, and antimicrobial activity.
The burden of disease for children born alive with Turner syndrome—A European cohort study
Authors: Andersen Ann‐Louise Rud , Urhoj Stine Kjaer , Tan Joachim , Cavero‐Carbonell Clara , Gatt Miriam , Gissler Mika , Klungsoyr Kari , Khoshnood Babak , Morris Joan , Neville Amanda J. , Pierini Anna , Scanlon Ieuan , de Walle Hermien E. K. , Wellesley Diana , Garne Ester , Loane Maria 
Published: July 2023

AbstractBackgroundTurner syndrome is a rare congenital anomaly caused by complete or partial X chromosome monosomy that may affect mortality and morbidity in childhood.MethodsThis population‐based data‐linkage cohort study, as part of the EUROlinkCAT project, investigated mortality and morbidity for the first 5 years of life for liveborn European children diagnosed with Turner syndrome. Thirteen population‐based registries in 10 countries from the European surveillance of congenital anomalies (EUROCAT) network participated. Data on children born 1995–2014 and diagnosed with Turner syndrome were linked to mortality, hospital and prescription records. Children with any congenital anomaly and children without a congenital anomaly were included for comparison on morbidity.ResultsOut of a population of 5.8 million livebirths 404 were diagnosed with Turner syndrome prenatally or in infancy and 95.5% survived to their fifth birthday. During the first year of life 72.3% (95% CI 59.5;81.6) of children with Turner syndrome were hospitalized, the median length of stay was 5.6 days (95% CI 3.5;7.7) and 18.7% (95% CI 13.9;23.9) underwent surgery. After the first year of life hospitalizations and length of stay decreased but more children underwent surgery (30.8% [95% CI 17.6;44.7]). In the first 5 years the percentage of children with Turner syndrome having a prescription for antibiotics was 12%–20% per year and increased with the age of child.ConclusionsIn the first year of life, the burden of disease was relatively high for children with Turner syndrome. The outlook is more positive beyond the first year, though overall morbidity still exceeded that of children without congenital anomalies.
A voxel‐based morphometry study on gray matter correlates of need for cognition and exploratory information seeking
Authors: Tolomeo Serenella , Lau Shermine , Ragunath Bindiya L. , Setoh Peipei , Esposito Gianluca 
Published: July 2023

AbstractBackgroundNeed for cognition (NFC) represents interindividual differences in tendencies to engage and enjoy cognitive endeavors. Exploratory information seeking (EIS) refers to individual tendencies to attain cognitive stimulation through acquiring information related to consumer products or services out of curiosity.MethodsThe current study aims to provide an in‐depth investigation of the relationship between NFC and EIS and extend this relation to determine neuroanatomical correlates of NFC and EIS. This study proposed two central hypotheses: (1) NFC and EIS scores are positively correlated and (2) the gray matter volume (GMV) of brain regions implicated in motivation, valuation, and reward systems are positively associated with both NFC and EIS. Self‐report and structural MRI data of 91 Singaporean Chinese participants were utilized for the study.ResultsNo statistically significant correlation was revealed between NFC and EIS scores. Neuroanatomical associations of the GMV of brain regions implicated in visuospatial, attentional, and reward processing with individual constructs of interest were explored. When examining NFC and EIS scores, larger GMV in the right pallidum and left fusiform gyrus was found in participants that reported higher levels of NFC (vs. lower NFC levels), larger GMV in the left precuneus in those with greater tendencies to engage in EIS (vs. lower EIS levels), and larger GMV of the left fusiform gyrus associated with greater endorsement of both NFC and EIS. When investigating the exploratory factor analysis–generated factors of NFC and EIS, similar patterns of associations were found between self‐reported levels of agreement against factors and GMV of brain regions implicated.ConclusionsCorrelational analysis and exploratory factor analysis indicated the absence of a relationship between NFC and EIS. Additionally, voxel‐based morphometry whole‐brain analysis revealed neuroanatomical correlates of the GMV of brain regions implicated in visuospatial, attentional, and reward processing with NFC and EIS.
Concise Total Synthesis and Biological Evaluation of Pargamicin A and its Diastereomer, Piperazic Acid‐containing Cyclopeptides
Authors: Yoshida Masahito , Inaba Tetsuya , Shibuya Yuko , Igarashi Masayuki , Kigoshi Hideo 
Published: July 2023

AbstractWe have accomplished the total synthesis, structure determination, and biological evaluation of pargamicin A and one of its diastereomers. Two key tripeptide segments were synthesized using a linear peptide elongation process that includes the direct coupling of a poorly nucleophilic piperazic acid derivative. The resulting tripeptides were coupled using triphosgene/collidine at ambient temperature leading to a precursor for the final cyclization step. T3P‐promoted macrolactamization under high‐dilution conditions, followed by the removal of the benzyl protecting group was used to furnish two putative structures of pargamicin A. Comparison of the 1H and 13C NMR spectra and the antibacterial activity of the natural and synthetic products successfully revealed that the absolute configuration of the N‐hydroxy‐Ile residue of pargamicin A is 2S,3S. A biological evaluation of synthetically obtained pargamicin A and its diastereomer suggested that the stereostructure of the cyclic peptide scaffold of the natural product plays a crucial role in determining the strength of its antibacterial activity.
A High‐Potential Bipolar Phenothiazine Derivative Cathode for Aqueous Zinc Batteries
Authors: Wang Yanrong , Qiu Shigui , He Dunyong , Guo Jiandong , Zhao Mengfan , Zheng Chenxi , Wang Xuemei , Wang Caixing 
Published: July 2023

AbstractAqueous zinc ion batteries (AZIBs) are gaining popularity as advanced energy storage devices that are economical, safe, and use resource‐abundant storage options. In this study, we have synthesized a bipolar phenothiazine organic scaffold known as 3,7‐bis(melaminyl)phenothiazin‐5‐ium iodide (PTDM), which is obtained by undergoing nucleophilic substitution through phenothiazinium tetraiodide hydrate (PTD) and melamine. Electrochemical results indicate that PTDM can act as a high‐potential cathode material for rechargeable AZIBs. In detail, the aqueous PTDM//Zn full cell exhibits a high average voltage of approximate 1.13 V, along with a specific capacity of 118.3 mAh g−1 at 0.1 A g−1. Furthermore, this demonstrated cell displays moderate long‐term cycling stability over 6400 cycles, which is encouraging and suggests potential for developing advanced organic electrode materials for rechargeable AZIBs.
Outstanding Compatibility of Hard‐Carbon Anodes for Sodium‐Ion Batteries in Ionic Liquid Electrolytes
Authors: Maresca Giovanna , Petrongari Angelica , Brutti Sergio , Battista Appetecchi Giovanni 
Published: July 2023

AbstractHard carbons (HC) from natural biowaste have been investigated as anodes for sodium‐ion batteries in electrolytes based on 1‐ethyl‐3‐methylimidazolium bis(fluorosulfonyl)imide ([EMI][FSI]) and N‐trimethyl‐N‐butylammonium bis(fluorosulfonyl)imide ([N1114][FSI]) ionic liquids. The Na+ intercalation process has been analyzed by cyclic voltammetry tests, performed at different scan rates for hundreds of cycles, in combination with impedance spectroscopy measurements to decouple bulk and interfacial resistances of the cells. The Na+ diffusion coefficient in the HC host has been also evaluated via the Randles‐Sevcik equation. Battery performance of HC anodes in the ionic liquid electrolytes has been evaluated in galvanostatic charge/discharge cycles at room temperature. The evolution of the SEI (solid electrochemical interface) layer grown on the HC surface has been carried out by Raman spectroscopy. Overall the sodiation process of the HC host is highly reversible and reproducible. In particular, a capacity retention exceeding 98 % of the initial value has been recorded in[N1114][FSI] electrolytes after more than 1500 cycles with a coulombic efficiency above 99 %, largely beyond standard carbonate‐based electrolytes. Raman, transport properties and impedance confirms that ILs disclose the formation of SEI layers with superior ability to support the reversible Na+ intercalation with the possible minor contributions from the EMI+cation.
CRISPRa system activates myokines FGF21 and FNDC5: Promoting fat browning and improving diet‐induced obesity in mice
Authors: Jiang Rui , Zhang Zhi , Jin Wanzhu 
Published: July 2023

AbstractObesity causes metabolic disorders and is one of the important risk factors for diabetes. Myokines are widely involved in lipid metabolism through autocrine, paracrine and endocrine actions. FGF21 and Irisin, as representative myokines, can promote the browning of adipocytes and are potential targets for the treatment of obesity. This commentary discusses the research by Zhu et al. published in Clinical and Translational Medicine. In this study, the expression of FGF21 and FNDC5 is simultaneously activated by the CRISPRa system in vivo and in vitro. In vitro, the cell culture supernatant of C2C12 cells activated by the CRISPRa system significantly promoted the differentiation and browning of 3T3‐L1 cells; in vivo, injecting of AAV9‐dCas9‐VP64 virus could significantly reduce the body weight and fat mass of DIO mice due to an increase in browning of adipocytes.
A case of T‐cell‐Epstein–Barr virus‐haemophagocytic lymphohistiocytosis and sustained remission following ruxolitinib therapy
Authors: Ali Syed , Choo Sharon , Hosking Laine , Smith Anthony , Hughes Tiffany 
Published: July 2023

AbstractObjectivesEpstein–Barr virus (EBV) is a common cause of secondary haemophagocytic lymphohistiocytosis (HLH). While B cells are reservoirs for EBV, infection within T cells and NK cells in this disease can be difficult to treat.MethodsA 19‐year‐old female presented with a 6‐week history of coryzal symptoms on a background of Crohn's disease. On examination, she was febrile and tachycardic with mild tonsillar enlargement and splenomegaly. New trilineage cytopenias and elevation in liver enzymes were detected, with acute EBV subsequently confirmed on whole blood PCR. A diagnosis of EBV‐associated HLH was supported further with elevated serum ferritin, triglycerides and soluble CD25, low fibrinogen and the presence of haemophagocytosis in the bone marrow.ResultsCorticosteroids, IVIG and rituximab were given, and anakinra was subsequently added due to ongoing fevers. EBV infection was then demonstrated within CD8+ T cells on EBER Flow‐FISH assay. Ruxolitinib was commenced and her fevers abated on day 5, with improvement in other HLH parameters. She was discharged after a 39‐day hospital admission. To date, she has remained in remission of HLH, despite developing COVID‐19 infection during the convalescence phase of HLH.ConclusionEBV viraemia requires adequate treatment to control EBV‐associated HLH as rituximab may be insufficient, and corticosteroid resistance can result in continued EBV infection in CD8+ T cells. This entity is known as T‐cell‐EBV‐HLH. Ruxolitinib is a novel treatment strategy in this specific context and has several advantages, including inhibition of corticosteroid resistance to promote apoptosis of EBV‐infected T cells.
Coursing the mottled mosaic: Generalist predators track pulses in availability of neonatal ungulates
Authors: Huggler Katey S. , Hayes Matthew M. , Burke Patrick W. , Zornes Mark , Thompson Daniel J. , Lionberger Patrick , Valdez Miguel , Monteith Kevin L. 
Published: July 2023

AbstractThe density and distribution of resources shape animal movement and behavior and have direct implications for population dynamics. Resource availability often is “pulsed” in space and time, and individuals should cue in on resource pulses when the energetic gain of doing so exceeds that of stable resources. Birth pulses of prey represent a profitable but ephemeral resource and should thereby result in shifting functional responses by predators. We evaluated movements and resource selection of coyotes (Canis latrans) across a gradient of reproductive stages ranging from late gestation to peak lactation of female mule deer (Odocoileus hemionus) in southwest Wyoming, USA, to test whether coyotes exhibited shifts in selection and movement behavior relative to the availability and vulnerability of neonatal mule deer. We expected coyotes to track pulses in availability of neonatal mule deer, and such behavior would be represented by shifts in resource selection and search behavior of coyotes that would be strongest during peak parturition of mule deer. Coyotes selected areas of high relative probability of use by female mule deer and did so most strongly during peak parturition. Furthermore, searching behavior of coyotes intensified during pulses of availability of deer neonates. Our findings support the notion that coyotes exploit pulses of neonatal deer, presumably as an attempt to capitalize on a vulnerable, energy‐rich resource. Our work quantifies the behavioral mechanisms by which coyotes consume ungulate neonates and provides one of the first examples of a mammalian predator–prey system centered on a pulsed resource.
Setting ‘green’ boundaries for Chinese green finance: Multi‐level governance and regulatory stringency
Authors: Cheng Wenting , Zhang Kai 
Published: July 2023

AbstractThis article focuses on setting ‘green’ boundaries for green finance in China—the scope of eligible ‘green’ projects to be supported by Chinese green finance. China started building its green finance system in 2015, and 23 provinces issued guidelines on green finance between 2016 and 2020. Applying multi‐level governance as our analytical framework, this study collects data from a broad range of publicly available sources, including 64 policies issued by Chinese state ministries, provinces or pilot zones, transcripts of relevant press conferences, and streamed speeches given by relevant stakeholders in online workshops. We explain who governs the ‘green’ boundary of Chinese green finance, how it is governed, and the implication for regulatory stringency. We identify three levels of regulators involved in setting green boundaries—central ministries through the horizontal allocation of overlapping mandates, provinces through vague references and priority lists, and green finance pilot zones through vertical knowledge co‐production. We argue that continuous multi‐level negotiation and coordination dynamics determine the ‘green’ boundary in Chinese green finance, which further influences regulatory stringency. While several provinces and a pilot zone did temporarily prioritise industries with local competitive advantages (as exemplified by clean coal) as eligible to be supported by green bonds, the central government disapproved of such practices by its strong coordinating authority. The regulatory stringency was also safeguarded by the influence of transnational networks and China's decarbonisation objectives.