bluuebunny/crossref_metadata_2025_split huggingface dataset:
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition
Authors: Mishima Saori , Naito Yoichi , Akagi Kiwamu , Hayashi Naomi , Hirasawa Akira , Hishiki Tomoro , Igarashi Ataru , Ikeda Masafumi , Kadowaki Shigenori , Kajiyama Hiroaki , Kato Motohiro , Kenmotsu Hirotsugu , Kodera Yasuhiro , Komine Keigo , Koyama Takafumi , Maeda Osamu , Miyachi Mitsuru , Nishihara Hiroshi , Nishiyama Hiroyuki , Ohga Shouichi , Okamoto Wataru , Oki Eiji , Ono Shigeru , Sanada Masashi , Sekine Ikuo , Takano Tadao , Tao Kayoko , Terashima Keita , Tsuchihara Katsuya , Yatabe Yasushi , Yoshino Takayuki , Baba Eishi 
Published: August 2023

Abstract
Background
Clinical trials have reported the efficacy of immune checkpoint inhibitors in the treatment of mismatch repair-deficient (dMMR) advanced solid tumors. The accumulated evidence of tumor agnostic agent has been made since PD-1 inhibitor was approved and used in clinical practice. Therefore, we have revised the guideline “Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition”.

Methods
Clinical questions regarding medical care were formulated for patients with dMMR advanced solid tumors. Relevant publications were searched by PubMed and Cochrane Database. Critical publications and conference reports were added manually. Systematic reviews were performed for each clinical question for the purpose of developing clinical recommendations. The committee members identified by Japan Society of Clinical Oncology (JSCO), Japanese Society of Medical Oncology (JSMO), and Japanese society of pediatric hematology/oncology (JSPHO) voted to determine the level of each recommendation considering the strength of evidence, expected risks and benefits to patients, and other related factors. Thereafter, a peer review by experts nominated from JSCO, JSMO, and JSPHO and the public comments among all societies’ members were done.

Results
The current guideline describes two clinical questions and eight recommendations for whom, when, and how MMR status should be tested.

Conclusion
In this guideline, the committee proposed eight recommendations for performing MMR testing properly to select patients who are likely to benefit from immunotherapy.
Absorbable cyst brushes
Authors: Marques Filipe , van der Wijngaart Wouter , Roxhed Niclas 
Published: August 2023

AbstractCytobrushes are used for low-invasive sample collection and screening in multiple diseases, with a significant impact on early detection, prevention, and diagnosis. This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely proportional to their plastic deformation by the needle. Our results open avenues for safer cell biopsies in hard-to-reach locations by utilizing brushes composed of absorbable materials.
Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia?
Authors: Tandirerung Fistra Janrio 
Published: August 2023

Abstract
Purpose of Review
This review discusses whether patients’ genotype affects the efficacy of PCSK9 inhibitors in treating familial hypercholesterolemia and how this might influence clinical management.

Recent Findings
Currently, available evidence consistently demonstrates and is in good agreement that, in general, the LDL-C-lowering effect of PCSK9 inhibitors is similar across genotypes, except for compound heterozygous and homozygous familial hypercholesterolemia (FH). However, it remains to be seen whether the comparable therapeutic effect in lowering LDL-C level also leads to a comparable degree of cardiovascular risk reduction with different genotypes.

Summary
Generally, the level of LDL-C reduction following PCSK9 inhibitor treatment is similar within different genotypes. Hence, genotype is a less reliable predictor for further LDL-C level reduction on PCSK9 inhibitor therapy, and attention should be given to other external influences, especially for heterozygous FH.
Parent-Child Inpatient Treatment in Child and Adolescent Mental Healthcare: Predictors of Child Outcomes
Authors: von Wirth Elena , Breuer Dieter , Schröder Sabine , Döpfner Manfred 
Published: August 2023

AbstractFamily inpatient units in child and adolescent mental health (CAMH) services engage all admitted family members in the treatment of children’s symptoms. Studies demonstrated improvements in child and family functioning following family inpatient treatment, but evidence regarding predictors of treatment outcome is lacking. We analyzed data of families (n = 66) who received a four-week inpatient treatment for families with severe parent-child interaction problems. Hierarchical linear regression analyses revealed that parents who recalled harsher parenting practices of their own fathers reported greater improvements in their children’s externalizing and internalizing problems. Greater improvements in externalizing problems were further predicted by lower parental educational level, less adverse impacts of stressful life events, and less internalizing child problems prior to admission. We therefore conclude that family inpatient treatment was particularly effective for children in families with lower parental education and a history of harsh parenting.
Genetic analysis of federally endangered Cape Sable seaside sparrow subpopulations in the Greater Everglades, USA
Authors: Beaver Caitlin E. , Virzi Thomas , Hunter Margaret E. 
Published: August 2023

AbstractThe federally endangered Cape Sable seaside sparrow (Ammospiza maritima mirabilis) is endemic to the Greater Everglades ecosystem in southern Florida, inhabiting fragmented marl prairies in six individual subpopulations. The subspecies is threatened by loss of breeding habitat from fire and water management. Genetic information is severely limited for the subspecies but could help inform decisions regarding subpopulation protections and potential translocations for genetic rescue. To provide genetic data and inform management efforts, feather samples were collected across five subpopulations (designated A–E) and protocols were tested to optimize DNA extraction yields. We assessed four mitochondrial DNA markers (N = 36–69) and 12 nuclear microsatellite loci (N = 55) in 108 sparrows. Mitochondrial DNA sequences revealed low haplotype diversity, with NADH dehydrogenase-2 haplotypes matching to most other extant subspecies and to the Atlantic coast subspecies. Nuclear diversity was low compared to other subspecies, but similar across subpopulations. Samples grouped as one population when analyzed by Principal Component Analysis, Bayesian modelling and genetic distance metrics. Limited genetic emigration was detected from one putative migrant. Relatedness was significantly different for sparrows in the most geographically distant subpopulation (A), likely reflecting high self-recruitment and natal site fidelity (P = 0.003). The low to moderate effective population size (NE = 202.4; NE:NC = 0.06) and generation time estimates indicated that unique genetic variation could be lost quickly during stochastic events. The sample sizes were limited, which reduced the power to comprehensively address recent population size reductions and any subsequent loss of genetic diversity.
Preference formation in demand for live theatre
Authors: Throsby David , Severn John R. , Petetskaya Katya 
Published: August 2023

AbstractIn economics, the concept of preferences is fundamental to the theory of choice. In many demand analyses, preferences are taken as given, although interesting questions can be asked about how they originate. In this paper, we consider the formation of preferences in demand for live theatre. We propose a model where preferences are derived from certain identifiable types of experience gained from past attendances at live theatre productions, as well as from some characteristics of consumers including their theatre-related human capital and their habitual behaviour patterns in attending a performance. We hypothesise that the preferences formed through these processes determine conditional demand for future live theatre consumption. The model is estimated as a two-stage system using data from a recent survey of theatregoers. The paper is interdisciplinary in its approach, drawing its modelling and methodologies from economics, and its interpretation of results from the academic discipline of theatre studies.
“I have been pushed outside of my comfort zone and have grown as a result”: Teacher professional learning and innovation during the pandemic
Authors: Santagata Rossella , Villavicencio Adriana , Wegemer Christopher M. , Cawelti Lora , Gatlin-Nash Brandy 
Published: August 2023

AbstractThis study examines opportunities for teacher professional growth and innovation during the COVID-19 pandemic. Survey data, including responses to both closed and open-ended questions, were collected from 276 elementary-school teachers who taught online in two school districts in California. Quantitative and qualitative analyses document the extent to which teachers experienced opportunities for professional growth and innovation, how they described these opportunities, and what factors explained variability in teachers’ responses. Contrary to some extant research produced in the last few years, teachers overwhelmingly agreed that the transition to online instruction provided opportunities to be innovative and to learn to teach with new technologies. Specifically, they reported new approaches for connecting with students and their families as well as integrating technology into classroom practice beyond the period of remote learning. Consistent with prior theory related to teacher learning, factors that predicted perceived opportunities included their overall satisfaction with the support provided by their school/district, collaboration with colleagues, and their self-efficacy for using technology to teach specific concepts and curriculum. Findings suggest implications for how to leverage this period of professional growth beyond the pandemic.
An application of dynamic programming to local adaptation decision-making
Authors: Muccione Veruska , Lontzek Thomas , Huggel Christian , Ott Philipp , Salzmann Nadine 
Published: August 2023

AbstractAdaptation decision-making in mountain regions necessitates dealing with uncertainties which are driven by the complex topography and the potential interconnections of stochastic events. Such events can lead to amplifying consequences for the exposed communities located at different elevations. In this study, we present a stylized application of stochastic dynamic programming for local adaptation decision-making for a small alpine community exposed to debris flows and floods. We assume that local decision-makers and planners aim at maximizing specific objectives by choosing from a feasible set of adaptation measures and under given constraints on these actions. Our results show that stochastic dynamic programming is a promising tool to address the underlying problem faced by local planners when evaluating the feasibility and effectiveness of adaptation measures. Furthermore, stochastic dynamic programming has some advantages compared to deterministic approaches which assume full knowledge of the system of interest in a world dominated by randomness. We provide an estimation of a best option and an appropriate metric to benchmark adaptation effectiveness for long time horizons. We show how multiple constraints, risk preferences, time horizons and decision periods all influence the decision-making and the overall success of adaptation responses over time.
Relating popularity on Twitter and Linkedin to bibliometric indicators of visibility and interconnectedness: an analysis of 8512 applied researchers in Germany
Authors: Howoldt David , Kroll Henning , Neuhäusler Peter 
Published: August 2023

AbstractWe analyse the degree to which the popularity of scientific authors on Twitter and LinkedIn corresponds to publication-based indicators as to their visibility and interconnectedness. Departing from the extant literature’s focus on the visibility of individual papers, we turn to the popularity of individuals on social media platforms. We explore whether this popularity is reflected in the visibility that researchers achieve and the collaborations they maintain in the publication domain. Studying a large sample of applied researchers in Germany, we find congruence between researchers’ popularity on social media, and both their visibility and interconnectedness in the publication domain. Comparing the effects of Twitter and LinkedIn engagement, we furthermore find that the characteristics of this relationship are associated with the intended function of the social media platform in which researchers engage. We conclude that social media platforms are a relevant channel of academic communication, alongside existing channels of formal and informal exchange.
Law Without Matter? The Immateriality Thesis: A Critical Commentary
Authors: Dudek Michał 
Published: August 2023

AbstractDespite its popularity in recent theorisations of law as an artifact, the idea that law is an immaterial being, independent from even the documents that contain legal acts, has not been subjected to a focused analysis. This paper fills this noticeable gap. After providing generalizing account of the Immateriality Thesis, based on its different expositions in the literature, the paper criticises it. First, it argues that it is based on the counterfactual assumption that semantic content can exist beyond any carrier for itself. The paper then elaborates on the thesis’ empirical implausibility, particularly its ignorance of how much the law is as it is due to writing. Third, the paper reveals how the thesis is difficult to combine with other jurisprudential issues, notably law’s effectiveness. Following such a critique, the paper considers the possible origins of and reasons for the thesis. Given its highly questionable character, the paper concludes with some general ideas on taking law’s materiality seriously.
Somatoforme Störungen als Herausforderung für die Arzt-Patient-Beziehung – eine quantitative Fragebogenerhebung zu Beobachtungen und Umgangsstrategien von Hausärzt*innen
Authors: Wangler Julian , Jansky Michael 
Published: August 2023

Zusammenfassung

Hintergrund
In der hausärztlichen Versorgung sind somatoforme Symptomatiken verbreitet und können eine besondere Herausforderung darstellen. Bislang fehlt es an Studien, die den Umgang von Hausärzt*innen mit entsprechenden Patient*innen in den Blick nehmen. Insbesondere Strategien zur Herstellung eines tragfähigen Arzt-Patient-Verhältnisses sind kaum erforscht worden.

Ziel der Arbeit
Die Studie hat eruiert, wie Hausärzt*innen das Beschwerdebild der somatoformen Störungen wahrnehmen, welche Bedeutung sie diesen beimessen und wie sie mit Patient*innen umgehen. Der Hauptfokus liegt auf erlebten Patient*innencharakteristika, vermuteten Ursachen somatoformer Störungen, Herausforderungen in der Sprechstunde, Betreuungs- und Stabilisierungsstrategien sowie diagnostischen Unterstützungsformen.

Material und Methoden
Mittels schriftlicher Befragung zwischen Januar und April 2023 wurden insgesamt 1398 Hausärzt*innen in Hessen und Rheinland-Pfalz anonymisiert befragt. Zur Feststellung von signifikanten Unterschieden zwischen zwei Gruppen kam ein t‑Test bei unabhängigen Stichproben zum Einsatz.

Ergebnisse
Die Befragten benennen zahlreiche Strategien, mit denen sie positive Erfahrungen gemacht haben, wenn es darum geht, Patient*innen zu stabilisieren. Die Schaffung einer tangentialen Arzt-Patient-Beziehung wird mit Maßnahmen flankiert, einerseits körperliche Ursachen konsequent auszuschließen, andererseits Patient*innen möglichst gut einschätzen zu können und behutsam an das Krankheitsbild somatoformer Störungen heranzuführen. Aktuelle Leitlinien sind den meisten Ärzt*innen nicht bekannt. Die Zusammenarbeit mit Spezialist*innen und Therapeut*innen wird verbreitet als schwierig beschrieben.

Schlussfolgerung
Hausärzt*innen greifen auf ein breites Spektrum an Kommunikations- und Stabilisierungsstrategien beim Management somatoformer Körperbeschwerden zu. Dennoch wird der Kontakt mit dieser Patient*innengruppe im Praxisalltag als beschwerlich erlebt. Langfristig wäre neben der Schaffung von mehr therapeutischen Betreuungskapazitäten und interdisziplinären Strukturen eine Stärkung niedrigschwelliger Therapie- und Unterstützungsangebote hilfreich.
High-performance fractional anisotropic diffusion filter for portable applications
Authors: AbdAlRahman Alaa , Al-Atabany Walid I. , Soltan Ahmed , Radwan Ahmed G. 
Published: August 2023

AbstractAnisotropic diffusion is one of the most effective methods used in image processing. It can be used to eliminate the small textures of an image while preserving its significant edges. In this paper, a new anisotropic diffusion filter is proposed based on a fractional calculus kernel rather than integer kernel to improve the overall performance of the filter. Integer and fractional anisotropic filters are implemented using the Genesys-2 FPGA kit to utilize the efficiency of parallelism in FPGAs. Integer and fractional anisotropic filters are tested against the achievable PSNR value vs the number of iterations. The proposed fractional anisotropic filter has a better PSNR value using a smaller number of iterations, reducing the power and area compared to integer anisotropic filter. The proposed filter can be used in image smoothing, edge detection, image segmentation, image denoising, and cartooning. In addition, the proposed filter reduces the power consumption by 58.2% compared to integer-order filters, which makes the proposed filter suitable for battery-based applications.
Continuous Dependence of Szegő Kernel on a Weight of Integration
Authors: Żynda Tomasz Łukasz , Pasternak-Winiarski Zbigniew , Sadowski Jacek Józef , Krantz Steven George 
Published: August 2023

AbstractThe weighted Szegő kernel was investigated in a few papers (see Nehari in J d’Analyse Mathématique 2:126–149, 1952; Alenitsin in Zapiski Nauchnykh Seminarov LOMI 24:16–28, 1972; Uehara and Saitoh in Mathematica Japonica 29:887–891, 1984; Uehara in Mathematica Japonica 42:459–469, 1995). In all of these, however, only continuous weights were considered. The aim of this paper is to show that the Szegő kernel depends in a continuous way on a weight of integration in the case when the weights are not necessarily continuous. A topology on the set of admissible weights will be constructed and Pasternak’s theorem (see Pasternak-Winiarski in Studia Mathematica 128:1, 1998) on the dependence of the orthogonal projector on a deformation of an inner product will be used in the proof of the main theorem.
Comparison of virus aerosol concentrations across a face shield worn on a healthcare personnel during a simulated patient cough
Authors: Pratt Alessandra A. , Brown Grant D. , Perencevich Eli N. , Diekema Daniel J. , Nonnenmann Matthew W. 
Published: August 2023

AbstractBackground:Patients diagnosed with coronavirus disease 2019 (COVID-19) aerosolize severe acute respiratory coronavirus virus 2 (SARS-CoV-2) via respiratory efforts, expose, and possibly infect healthcare personnel (HCP). To prevent transmission of SARS-CoV-2 HCP have been required to wear personal protective equipment (PPE) during patient care. Early in the COVID-19 pandemic, face shields were used as an approach to control HCP exposure to SARS-CoV-2, including eye protection.Methods:An MS2 bacteriophage was used as a surrogate for SARS-CoV-2 and was aerosolized using a coughing machine. A simulated HCP wearing a disposable plastic face shield was placed 0.41 m (16 inches) away from the coughing machine. The aerosolized virus was sampled using SKC biosamplers on the inside (near the mouth of the simulated HCP) and the outside of the face shield. The aerosolized virus collected by the SKC Biosampler was analyzed using a viability assay. Optical particle counters (OPCs) were placed next to the biosamplers to measure the particle concentration.Results:There was a statistically significant reduction (P< .0006) in viable virus concentration on the inside of the face shield compared to the outside of the face shield. The particle concentration was significantly lower on the inside of the face shield compared to the outside of the face shield for 12 of the 16 particle sizes measured (P< .05).Conclusions:Reductions in virus and particle concentrations were observed on the inside of the face shield; however, viable virus was measured on the inside of the face shield, in the breathing zone of the HCP. Therefore, other exposure control methods need to be used to prevent transmission from virus aerosol.
Les (in)égalités de représentation en politique québécoise
Authors: Ferland Benjamin , Desrochers Éric 
Published: August 2023

RésuméL'article évalue l’état de la représentation substantive des femmes, des individus moins éduqués, moins fortunés, des jeunes ainsi que des allophones en politique provinciale québécoise. La représentation des citoyen(ne)s par les partis politiques est conceptualisée selon trois types de congruence idéologique: 1) le parti étant idéologiquement le plus proche des citoyen(ne)s; 2) le parti pour lequel les citoyen(ne)s ont voté; et 3) le système partisan. Nous évaluons ces formes de représentation face à cinq dimensions structurant la politique québécoise, permettant ainsi une approche multidimensionnelle à la représentation : l'axe souverainiste-fédéraliste, l'axe gauche-droite, les dépenses sociales, les dépenses en environnement, ainsi que l'immigration. Nos résultats présentent un portrait complexe de la représentation. Bien que certains groupes apparaissent moins bien représentés (en particulier, les femmes et les individus moins éduqués) aucun groupe ne l'est de façon systématique, et certains groupes sont parfois même avantagés (en particulier, les jeunes).