bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributed non-disclosive validation of predictive models by a modified ROC-GLM
Authors: Schalk Daniel , Hoffmann Verena S. , Bischl Bernd , Mansmann Ulrich 
Published: February 2023

Abstract
Background: Distributed statistical analyses provide a promising approach for privacy protection when analyzing data distributed over several databases. This approach brings the analysis to the data, rather than the data to the analysis. Instead of directly operating on data, the analyst receives anonymous summary statistics, which are combined into an aggregated result. Further, in model development, it is key to evaluate a trained model w.r.t. to its prognostic or predictive performance. For binary classification, one technique is analyzing the receiver operating characteristics (ROC). Hence, we are interested to calculate the area under the curve (AUC) and ROC curve for a binary classification task using a distributed and privacy-preserving approach.
Methods: We employ DataSHIELD as the technology to carry out distributed analyses, and we use a newly developed algorithm to validate the prediction score by conducting distributed and privacy-preserving ROC analysis. Calibration curves are constructed from mean values over sites. The determination of ROC and its AUC is based on a generalized linear model (GLM) approximation of the ROC curve, the ROC-GLM, as well as on ideas of differential privacy (DP). DP adds noise (quantified by the ℓ2 sensitivity Δ2( ˆf)) to the data. The appropriate choice of the ℓ2 sensitivity was studied by simulations.
Results: In our simulation scenario, the true and distributed AUC measures differ by ΔAUC < 0.01 depending on the choice of the differential privacy parameters. It is recommended to check the accuracy of the distributed AUC estimator in specific simulation scenarios when Δ2(ˆf) > 0.07. Here, the accuracy of the distributed AUC estimator may be impaired by too much artificial noise added from DP.
Conclusions: The applicability of our algorithms depends on the sensitivity of the underlying statistical/predictive model. The simulations carried out have shown that the approximation error is acceptable for the majority of simulated cases. For models with high sensitivity, the privacy parameters must be set accordingly higher to ensure sufficient privacy protection, which affects the approximation error. This work shows that complex measures, as the AUC, are applicable for validation in distributed setups while preserving an individual’s privacy.
The Drosophila Epidermal growth factor regulates Hedgehog-signalling cytoneme dynamics.
Authors: Gradilla Ana , Sánchez-Hernández David , Jiménez-Jiménez Carlos , Jordán-Álvarez Sheila , Aguirre-Tamaral Adrián , Sánchez Irene , Wakefield James , Guerrero Isabel 
Published: February 2023

Abstract

During Drosophila epithelial development, signalling specialized filopodial or cytonemes establish direct contacts between distant cells to facilitate the formation of the Hedgehog (Hh) signalling gradient. However, the regulatory mechanisms for Hh cytoneme initiation and their dynamic behaviour are still unknown. Here we show that Hh cytoneme dynamics in Drosophila epithelia depends on the Epidermal Growth Factor (EGF) signalling pathway through its ligand Spitz. We describe that the EGF pathway is required to maintain basal plasma membrane levels of the adhesion protein and Hh co-receptor Ihog, able to modify cyoneme behaviour. Furthermore, we describe that EGF signalling promotes Ihog interaction with actin cytoskeleton regulators, such as the actin cross-linker Filamin A, Cheerio (Che) in Drosophila. Cheerio is recruited by Ihog towards focalized small regions of the plasma membrane to contribute to the cytoneme stabilization function of Ihog. Finally, we describe that EGF regulation and PI3K signalling act synergically on Hh cytoneme behaviour, revealing a new form of cooperation between major tissue organizers.
Highly purified-hMG versus rFSH in ovarian hyperstimulation in women undergoing elective fertility preservation
Authors: Israeli Tal , Samara Nivin , Barda Shimi , Groutz Asnat , Azem Foad , Amir Hadar 
Published: February 2023

Abstract
Purpose: To compare recombinant FSH (rFSH) with highly purified-human menopausal gonadotrophin (hp-hMG) on ovarian response in women undergoing elective fertility preservation (FP).
Methods: This retrospective study included 456 women who underwent elective FP with gonadotropin-releasing hormone (GnRH) antagonist or progestin-primed ovarian stimulation (PPOS) protocols between 01/2017-12/2021. Three-hundred and forty-one women were stimulated with rFSH and 115 with hp-hMG, and the ovarian stimulation outcomes were compared between the two groups. A multivariate linear regression analysis assessed the impact of age, basal FSH level, antral follicle count, and protocol type on the ovarian stimulation outcomes.
Results: Women in the rFSH group were significantly younger, and their antral follicle count was significantly higher than those in the hp-hMG group (35.50±2.12 vs. 35.99±2.13 years, P = 0.034 and 13.76±6.08 vs. 11.84±6.06, P = 0.002). There were no significant group differences in the amount (P = 0.645) and duration (P = 0.265) of FSH stimulation. The peak estradiol level was significantly lower for the rFSH group compared to the hp-hMG group (2547.18±1648.21 pg/mL vs. 3468.02±2497.69 pg/mL, P < 0.001), while peak progesterone level was significantly higher (1.33±0.75 ng/mL vs. 1.01±0.52 ng/mL, P = 0.001). The numbers of retrieved and MII oocytes were significantly higher for the rFSH group compared with the hp-hMG group (16.82±10.95 vs. 13.25±9.66, P = 0.02, and 13.22±9.13 vs. 9.76±7.11, P = 0.005), while the maturity rates were comparable (P = 0.103).
Conclusion: rFSH was demonstrated to have superior oocyte yield compared to hp-hMG in ovarian hyperstimulation for women undergoing elective FP.
Bacterial nanocellulose membranes for codelivery of carvacrol and thymol: physico-chemical characterization and in vitro studies
Authors: Gabbai-Armelin Paulo Roberto , De Oliveira Analu , Rodero Camila , Silva Jhonatan , Fernandes Natalie , Paiva Robert , Dametto Alessandra , Chorilli Marlus , Barud Hernane , Brighenti Fernanda 
Published: February 2023

Abstract
Skin wounds represent a worldwide problem. Biopolymers have been attracting interest for healthcare products toward wound dressing. Among these biopolymers, bacterial nanocellulose membranes (BNC), with its tridimensional and branched nano- and microfibrillar structure, are attractive. Despite that, BNC present no antimicrobial activity. Thus, the incorporation of the monoterpenes Carvacrol (Car) and Thymol (Thy) - which present antimicrobial and healing properties - toward the improvement of skin wound healing, consists of an appealing approach. This research aimed to produce and characterize nanocellulose membranes containing carvacrol and/or thymol, and investigate their release behavior, cytotoxicity and antimicrobial properties. BNC/Car, BNC/Thy and BNC/Car-Thy membranes were produced at doses of 0.1 and 1.0 mg/cm2. The natural components incorporation into the nanocellulose did not interfere neither on ultra-structure nor on its physic characteristics. Release experiments showed a burst release between 2–4 h with sustained release till 24 h, reaching around 80% of the initial amount of the incorporated monoterpenes. Studies with fibroblast and keratinocytes indicated no cytotoxicity and that cells could proliferate over the BNC/Car-Thy membranes. Microbiological studies suggested some antimicrobial potential of the BNC doped with Car and Thy. This innovative biomaterial has the potential for health care products.
AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progression
Authors: Ma Peng , Hao Ying , Wang Wei , Zhang Yue-Feng , Yu Kai-Huan , Wang Wei-Xing 
Published: February 2023

Abstract
Intrahepatic cholangiocarcinoma (ICC) is a fatal disease and the molecular mechanism of its progression is unknown. Aurora Kinase B (AURKB) is a central regulator of chromosome separation and cytokinesis and is abnormally expressed in a variety of cancer cells. This research aimed to explore the effect of AURKB in occurrence and metastasis of ICC. We found that AURKB showed a progressive up-regulation pattern from normal bile duct tissue to ICC with high invasion. Our data showed that AURKB significantly promoted ICC cell proliferation, induced epithelial-mesenchymal transition (EMT), migration and invasion through gain- and loss- of function experiments. In vivo results consistently showed that AURKB up-regulation not only promoted tumor growth, but also promoted tumor metastasis. Importantly, we discovered that AURKB regulates the expressions of EMT-related genes via PI3K/AKT signaling axis. Thus, our results suggest that AURKB induced EMT through the activation of PI3K/AKT signaling pathway is critical to the progression of ICC, which may be a prospective therapeutic treatment for overcoming ICC metastasis and progression.
Finite element analysis on pushing the molar backwards using invisible aligner with different migration displacement
Authors: Zhang J. W. , Ma L. L. , Ren Y. Z.X. , Zhou Y. Q. , Wei R. , Rong Q. G. 
Published: February 2023

Abstract
This paper examines the biomechanical mechanism behind the effect of the invisible aligner technique on tooth movement processes. To compare the effects of different target positions on tooth movement and the periodontal ligament (PDL), two kinds of aligners were designed to provide displacements of 0.2 mm and 0.3 mm. Different displacements of the maxillary second molar were simulated using the finite element (FE) method. The results of numerical simulations showed that the maximum stress was in the PDL of the distal surface and the palatal surface. The aligner that provided a displacement of 0.2 mm was more suitable for pushing the second molar backwards in the initial stage. In addition, the displacement and rotation of teeth during orthodontic treatment were measured and analysed.
Production of biodiesel from non-edible Parkia biglobosa oil under acidic condition
Authors: Takase Mohammed , Kipkoech Rogers 
Published: February 2023

Abstract
In this study biodiesel was produced from Parkia biglobosa via optimization of transesterification reaction condition (methanol to oil ratio, catalyst concentration, reaction temperature and reaction time) under sulphuric acid catalyst (H2SO4). Oil was first extracted from Parkia biglobosa seeds using soxhlet extraction method. The physico-chemical properties of the biodiesel were analysed and then compared to international standards. Subsequently, the oil was then used to produce biodiesel at optimized transesterification reaction conditions. At the end, the free fatty acid (FFA) content of the oil was 1.61% w/w while the saponification value (mgKOH/g) was 191.65. The maximum yield (percentage weight) of the biodiesel produced was 93.4% at the maximum transesterification conditions of methanol to oil molar ratio of 6:1, sulphuric acid catalyst amount of 3 wt %, reaction temperature of 65\(℃\) and reaction time of 1.5 h. When compared with other international standards the biodiesel produced was found to be within the limits of the specification by ASTM D6751 (American standard), EN 14241 (European Standard) and Ghana Standard Authority. It was therefore recommended that biodiesel from Parkia biglobosa seed oil under acidic catalytic condition is a potential new non-edible substitute for petroleum diesel for commercialization purposes.
Synthesis and photoluminescence properties of Ce3+ and Tb3+ doped Na3Gd(PO4)2 phosphors for white LEDs
Authors: Xie Meiling , Fang Minghao , Huang Zhaohui , Liu Yan’gai , Wu Xiaowen , Min Xin 
Published: February 2023

Abstract
In this paper, Na3Gd(PO4)2 phosphors, doped with rare-earth metal ions Ce3+ and Tb3+ were fabricated by the solid-state reaction method. Under the excitation of 340 nm light, the Ce3+-doped Na3Gd(PO4)2 phosphors exhibit a broad emission band ranging from 370 nm to 480 nm, which emitted bule light centered at 405 nm. When excited at 373 nm, the Tb3+-doped Na3Gd(PO4)2 phosphors presented a green light emission, including a strong peak at 547 nm. In addition, both of the Na3Gd(PO4)2: Ce3+ and Na3Gd(PO4)2: Tb3+ phosphors showed excellent thermal stability at different temperatures, of which the emission intensities at 150°C could maintain about 84% and 92.9% of those at room temperature, respectively. A prototype of the white light-emitting diodes lamp exhibiting bright white light was fabricated by using a 365 nm near-ultraviolet-emitting LED chip, combined with Na3Gd(PO4)2: Ce3+ blue phosphors, Na3Gd(PO4)2: Tb3+ green phosphors, and Na3Gd(PO4)2: Eu3+ red phosphor, which produced a high color rendering index of 89.4, and a relatively low correlated color temperature of 5496 K. Moreover, the CIE point is calculated to be at (0.3332, 0.3438), locating in the white light region. These results indicate that the as-prepared phosphors can be considered as potential candidates for ultraviolet/near-ultraviolet light-excited white light-emitting diodes applications.
Regulations of hydrophilicity of cellulosic nanosheets by polarity of coagulation bath
Authors: Li Lvgang , Huang Fei , Guo Yifan , Wang Jiahao , Zhang He , Zeng Rong , Zhou Zuowan 
Published: February 2023

Abstract
Regeneration from cellulose solution is an effective way for processing and regulating the cellulose-based materials, during which the coagulation bath plays an important role that has been paid insufficient attention. Herein, we investigate the effect of polarity of the coagulation baths on the hydrophilicity of the regenerated cellulose, and the results show that polarity of the coagulation bath affects the crystalline assembly along different crystal plane by regulating the molecular interactions, leading to discriminating surfaces of hydrophilicity. Strong-polar coagulation bath, such as H2O, induces the regeneration of cellulosic molecules along 11¯0 crystal plane, leading to form hydrophilic nanosheets. Lowering the polarity of the coagulation baths results in fragmenting the morphology and reducing the hydrophilicity of the nanosheets that regenerate along the 110 or 020 crystal planes. Molecular dynamics simulations reveal the mechanisms for the interactions between the polar groups in cellulosic molecules and the hydrophilic facet of the regenerated cellulose. During the regeneration process, the cellulosic molecules are assembled under the influence of van der Waals interactions, resulting in crystallizing along the direction of 110 face to form the two-dimensional nanosheets. As the polarity of the coagulation bath changes from strong to weak, the assembly regeneration evolves from along 11¯0 to 110 or 020 crystal planes, which is recognized by the interaction changing from Van der Waals to hydrogen bond in cellulosic chains. As a result, the cellulose regenerates two-dimensional nanosheets with different hydrophilicity on the surface. The experimental and calculating results provide the feasibility for structural regulation of regenerated cellulosic materials with demand performance of different hydrophilicity.
Efficacy of the Addition of Robot-assisted Radical Cystectomy with Extracorporeal Urinary Diversion after an Enhanced Recovery Protocol
Authors: Nagayama Jun , Yamamoto Akiyuki , Naito Yushi , Kamikawa Hiroki , Kanazawa Hideyuki , Asano Akiyuki , Sho Norie , Terashima Yasuhiro 
Published: February 2023

Abstract
Background: Evaluation of the benefits to postoperative outcomes of introducing robot-assisted radical cystectomy (RARC) to enhanced recovery after surgery (ERAS) is limited, especially in RARC with extracorporeal urinary diversion (eRARC). We assessed whether eRARC, when added to ERAS, provided additional efficacy in terms of patient outcomes during its initial implementation.
Methods: We retrospectively identified 143 patients undergoing radical cystectomy with urinary diversion between June 2010 and December 2021 at a single center. The patients were assigned to three groups based on the type of surgical procedures and perioperative recovery protocols used. Length of hospital stay (LOS) and 90-day postoperative complication rates were compared between the groups. Regression analyses were performed to evaluate how ERAS and eRARC affected outcomes. Whereas, multivariate analysis was used to detect LOS predictors.
Results: The median LOS was shorter with ERAS and eRARC (28.0 vs. 20.0 vs. 17.0 days, P < 0.001). In the linear regression model, ERAS was associated with a significantly shorter LOS (10.4 days, P < 0.001); eRARC was also associated with a shorter LOS, but the difference was nonsignificant (4.10 days, P = 0.14). Neither ERAS nor eRARC was associated with a significant improvement in complications. Following multivariate analysis, ERAS was found to be independently associated with shorter LOS (OR 0.23, P < 0.001), but eRARC showed no such association (OR 0.29, P = 0.096).
Conclusion: ERAS was significantly associated with shorter LOS. Although a desirable trend was evident, eRARC did not contribute to additional efficacy. Neither ERAS nor eRARC improved complications.
Psychotic vulnerability and its associations with clinical characteristics in children and adolescents with Obsessive-Compulsive Disorder
Authors: Borrelli Davide Fausto , Cervin Matti , Ottoni Rebecca , Marchesi Carlo , Tonna Matteo 
Published: February 2023

Abstract
Compared to peers, children, and adolescents with Obsessive-Compulsive Disorder (OCD) are at increased risk of developing psychotic disorders. Yet very few studies have examined early indicators of psychosis in pediatric OCD. In the present study, 52 pediatric outpatients (mean age = 15.66 [SD = 2.33], 59.6% girls) with a primary diagnosis of OCD were interviewed using the Schizophrenia Proneness Instrument Child and Adolescent version (SPI-CY), which is a comprehensive clinical interview assessing both Cognitive–Perceptual basic symptoms (COPER) and high-risk criterion Cognitive Disturbances (COGDIS). Associations between COPER/COGDIS symptoms and demographic and clinical characteristics were examined. COPER or COGDIS symptoms were present in 44% of participants, with no significant difference in frequency between girls and boys. Psychotic vulnerability was associated with an earlier age of OCD onset, greater OCD severity, and poorer insight. Further, it was strongly associated with worse psychosocial functioning and explained 22% of unique variance in this variable. Findings suggest that early indicators of psychosis are frequent in pediatric OCD and associated with more severe OCD and poorer functioning. Research examining how psychotic vulnerability in pediatric OCD is associated with short- and long-term outcome is needed.
Frontiers and Emerging Trends in Cardiorenal Syndrome biomarker: A Bibliometric and Visualized Analysis from 2003 to 2022
Authors: Mao Xinxin , Zheng Haoran , Fu Zhenyue , Lv Jiayu , Shi Shuqing , Xu Xia , Wang Yajiao , Li Yumeng , Zhang Bingxuan , Wu Huaqin , Song Qingqiao 
Published: February 2023

Abstract
Background: Since the term of Cardiorenal syndrome (CRS) was proposed, the field has attracted much attention, and research on biomarkers of CRS has gradually emerged. Now, many CRS biomarkers have been identified and applied in clinical practice for disease diagnosis, treatment guidance, prognosis prediction and so on. In this study, bibliometrics was used to analyze the current status, research hotspots and frontiers of CRS biomarkers, in order to provide some valuable information for the research in this field.
Methods: Literature related to CRS biomarkers in the Web of Science database from 2003 to 2022 was searched. Based on CiteSpace, Vosviewer software and R program, the bibliometrics method was adopted to conduct quantitative retrospective analysis, visual presentation and result interpretation of the included literatures.
Results: A total of 577 literatures related to CRS biomarkers were included.Since the study was carried out, the number of published papers has been on the rise. The United States dominates the field; The San Bortolo Hosp's publication ranks first; Claudio Ronco is the most influential author in the field, with an absolute advantage in the number of publications and citations. CARDIORENAL MEDICINE (IF=4.36) is the most published journal focusing on CRS research.Finally, the biomarkers and research hotspots of CRS are introduced.
Conclusion: The exploration of new biomarkers is still a hotspot in this field, and their value in efficacy and prognosis is a potential research direction. Exploring the mechanism of disease and pathophysiology may be the forefront of research in this field in the future.
Effects of high intensity and progressive volume resistance training on functional, mental states, and quality of life of people with spinal cord injury
Authors: Rodrigues Joel Alves , Torres Eveline , Pereira Jaqueline Salgado Lopes , Teixeira Robson Bonoto , Silva Sandro Fernandes da , Aidar Felipe José , de Oliveira Cláudia Eliza Patrocínio , Encarnação Samuel Gonçalves Almeida da , Forte Pedro , Teixeira José Eduardo , Monteiro António Miguel de Barros , Moreira Osvaldo Costa 
Published: February 2023

Abstract
Objective: To establish the effect of high intensity and progressive volume resistance training (HIRT), on general health, functional, mental status, and quality of life (QOL) indicators in people with spinal cord injury (SCI). Methods: The sample consisted of 5 people with SCI of both sexes, aged 46.2 ± 13.9 years, submitted to 12 weeks of HIRT, twice a week. Were analyzed before and after the 12 weeks of intervention: body composition, muscle strength, functional status, perception of mental status, and QOL, using the following tests: dual-energy x-ray densitometry, 1RM, isometry of biceps, elbow flexion, Wingate, zigzag, medicine ball pitch, Beck inventory (anxiety, depression and mental disorder) and SF-36. Results: The results pointed to an increase in the training load, the total bone mineral content (p= 0.043), the muscle power at 80% of 1RM (p = 0.043), the functional state (anaerobic power [= 6,81%; p= 0.043] and explosive strength [= 30,57%; p= 0.043] of the shoulder girdle muscles), the mental state (= 71,46%; p= 0.006) and finally, improvement in QOL, especially in the functional (= 60,87%; p= 0.006) and social aspects (= 44,44%; p= 0.006). Conclusions: HIRT can improve or maintain body composition, developing muscle power, anaerobic power, and explosive strength of the upper limbs that will impact functional capacity, promoting greater autonomy, with consequent reflex in improving mental state and of the QOL of the person with SCI.