bluuebunny/crossref_metadata_2025_split huggingface dataset:
An efficient mm‐waveLNAimpedance match synthesis methodology with coordinate descent method
Authors: Zhou Jiangcheng , Wen Jincai , Wang Xu 
Published: July 2023

AbstractIn this paper, a novel synthesis methodology for LNA impedance matching is proposed, which consists of two main phases: database generation and parameter optimization. In the former phase, a large‐scale sweep of electromagnetic simulations of passive components is performed to speed up parameter optimization. In the latter phase, the coordinate descent method is used as the optimizer of this methodology. Since frequently dozens of parameters need to be optimized in synthesize LNAs, the coordinate descent method can temporarily fix some parameters in each iteration, thus convert the optimization problem into multiple simple low or even one‐dimensional optimizations, which can eventually obtain high‐quality LNAs quickly in fewer descent iterations. This methodology is applied to a Ka‐band two‐stage differential LNA design using 65 nm CMOS technology, and the synthesis time is only 3 min, which is tens of times faster compared to existing synthesis methods. The proposed LNA circuit is fabricated and the measured results verify the feasibility of the synthesis method.
Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes
Authors: Arunachalam Lalitha Tanjore , Suresh Snophia , Lavu Vamsi , Vedamanickam Shankarram , Viswanathan Sathiyapriya , Thirumalai Nathan Renuka Devy 
Published: July 2023

AbstractBackgroundAberrant deoxyribonucleic acid (DNA) contributes to inflammasome orchestrated progression of chronic inflammatory diseases like diabetes and periodontitis. The purpose of the present study was to estimate salivary levels of DNA sensing inflammasomes, absent in melanoma 2 (AIM2), interferon γ inducible protein (IFI16), and cytokine interleukin 18 (IL18) in individuals with periodontitis, diabetes, and healthy controls and interpret its association with periodontal and diabetic parameters.MethodsSalivary levels of AIM2, IFI16, and IL18 were estimated by enzyme linked immunosorbent assay (ELISA) in a total of 120 individuals (n = 30 in each group), namely, healthy (Group 1), periodontitis (Group 2), diabetes (Group 3), and diabetes with periodontitis (Group 4). Correlations of inflammasome levels and periodontal clinical parameters—plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), and periodontal inflamed surface area (PISA) were performed. Multiple regression was carried out to predict AIM2 and IFI16 with various independent variables.ResultsThe mean salivary levels of AIM2, IFI16, and IL18 were highest in diabetes with periodontitis (Group 4) and least in healthy (Group 1) and statistically significant between the groups (p = 0.000). Significant positive correlation between clinical periodontal parameters and AIM2, IFI16, and IL18 was present (p ≤ 0.05). Multiple regression showed glycated hemoglobin (HbA1C) (p = 0.002), GI (p = 0.016), PISA (p = 0.002), and CAL (p = 0.004) were significant predictors of AIM2, while HbA1C (p = 0.012), PISA (p = 0.003), and CAL (p = 0.007) predicted IFI16.ConclusionThe results of the present study showed higher levels of AIM2, IFI16, and IL18 in saliva of individuals with diabetes and periodontitis. HbA1C, PISA, and CAL were significant independent predictors of salivary AIM2 and IFI16 levels.
Comparison of in vitro starch digestibility and structure of matcha‐fortified starch vermicelli from different botanical sources
Authors: Li Yun , Niu Liya , Sun Chao , Tu Jin , Xiao Jianhui 
Published: July 2023

AbstractBACKGROUNDIn a study to explore the utilization of polyphenols in complex digestive systems, starch‐based vermicelli was employed as the carrier and matcha (MT) was used as the source of polyphenols. Four percent MT was extruded with A‐, B‐, and C‐type starch of rice, sweet potato, and mung bean to prepared starch vermicelli rice starch vermicelli (RSV), sweet potato starch vermicelli (SPSV), and mung bean starch vermicelli (MBSV), respectively. The multi‐scale structure of starch, the digestive kinetics of starch, and the bioaccessibility of polyphenols during in vitro digestion were monitored.RESULTSMatcha did not change the crystal configuration of vermicelli, but increased the relative crystallinity of RSV. Vermicelli with MT possessed a more uniform structure, and the polydispersity index decreased from 3.85–4.89 to 2.56–3.69. However, these structural changes made only a limited contribution to delaying digestion. The detection of polyphenols during digestion revealed that the release of most polyphenols was accomplished in the first 20 min of digestion. The release amount was in the order RSV + MT > MBSV + MT > SPSV + MT, and reached 4.81–5.45 mg GAE g−1. Correspondingly, the activity of digestive enzyme decreased in the order RSV + MT < MBSV + MT < SPSV + MT. Consequently, MT significantly (P < 0.05) reduced the digestive rate of vermicelli, and the rapidly digested starch and predicted glycemic index of RSV + MT decreased from 71.28% to 56.31% and from 74.68 to 62.86, respectively. The released polyphenols were also the main source of the strong antioxidant capacity of vermicelli with MT.CONCLUSIONSThese results provided a theoretical basis for using polyphenols to pursue healthy starch‐based food. © 2023 Society of Chemical Industry.
Effect of elaboration process, crop year and irrigation on acrylamide levels of potential table olive varieties
Authors: Fernández Antonio , Martillanes Sara , Lodolini Enrico Maria , Martínez Manuel , Arias‐Calderón Rocío , Martín‐Vertedor Daniel 
Published: July 2023

AbstractBACKGROUNDTable olives are widely consumed in the Mediterranean diet, and several typical Spanish and Portuguese varieties could potentially be used as such. In order to ensure a good‐quality product, the effect of different factors such as elaboration processes, irrigation conditions, crop year and their crossover interaction on acrylamide content and antioxidant compounds needs to be deeply studied.RESULTSWhen looking through irrigation, regulated deficit irrigation (RDI) presented lower acrylamide levels than rainfed conditions for ‘Cordovil de Elvas’, ‘Picual’ and ‘Verdeal Alentejana’. No significant interactions were found between the type of irrigation and elaboration style for ‘Arbequina’ and ‘Koroneiki’ varieties. Although RDI had the largest concentration of total phenols, antioxidant activity was also the highest. The table olives harvested in the crop year of 2019 showed lower levels of acrylamide due to a significant relationship between the crop year and irrigation conditions.CONCLUSIONSNovel varieties to be marketed should be taken into consideration for table olive elaboration. The impact of the crop year on the bioactive value of table olives and crossover interactions relies strongly in climatological conditions. Last but not least, the benefit of selecting the best irrigation and elaboration methods is crucial to ensure desirable acrylamide levels. © 2023 Society of Chemical Industry.
Optimized hybrid dielectrophoretic microchip for separation of bioparticles
Authors: Mahani Moheb Amir , Karimvand Ahmad Naseri , Naserifar Naser 
Published: July 2023

Point‐of‐care diagnostics requires a smart separation of particles and/or cells. In this work, the multiorifice fluid fractionation as a passive method and dielectrophoresis‐based actuator as an active tool are combined to offer a new device for size‐based particle separation. The main objective of the combination of these two well‐established techniques is to improve the performance of the multiorifice fluid fractionation by taking advantage of dielectrophoresis‐based actuator for separating particles. Initially, by using numerical simulations, the effect of using dielectrophoresis‐based actuator in multiorifice fluid fractionation on the separation of particles was investigated, and the size of the device was optimized by 25% compared to a device without dielectrophoresis‐based actuator. Also, adding dielectrophoresis‐based actuator to multiorifice fluid fractionation can extend the range of flow rates needed for separation. In the absence of dielectrophoresis‐based actuator, the separation took place only when the flow rate is 100 μL/min, in the presence of dielectrophoresis‐based actuator (20 Vp‐p), the separation happened in flow rates ranging from 70 to 120 μL/min.
Green analytical chemistry‐driven response surface modeling to stability‐indicating chromatographic method for estimation of cilnidipine and application of high‐performance thin‐layer chromatography–mass spectrometry for characterization of degradation products
Authors: Prajapati Pintu , Dixit Varsha , Pulusu Veera Shakar , Chauhan Renu , Shah Shailesh 
Published: July 2023

Cilnidipine is a calcium channel blocker that is used to treat cardiac diseases such as angina and high blood pressure. Several column and planar chromatographic methods for estimating cilnidipine in pharmaceutical dosage forms have been documented. However, these method developments have been carried out employing organic solvents such as acetonitrile, methanol, toluene, chloroform, and others as mobile phase components or as sample pretreatment diluents. These organic solvents are neurotoxic and teratogenic to humans and aquatic animals, according to International Council for Harmonization Q3C (R8) recommendations. According to the green analytical chemistry approach, such organic solvents should be reduced or removed during the development of chromatographic methods for environmental protection and the safety of human and aquatic animal life. As a result, the stability‐indicating chromatographic estimation of cilnidipine was performed utilizing less toxic organic solvents. To prevent organic solvent waste during method development, mobile‐phase optimization was performed using the design of experiment‐based response surface modeling. Cilnidipine has been subjected to hydrolysis, oxidation, photolysis, and dry‐heat decomposition to determine its stability. The greenness profiles of the suggested and published chromatographic methods were examined using the national environment method index, analytical greenness calculator, green analytical procedure index software, and eco‐scale assessment tool.
Thermochemical behavior and kinetics study of algae pyrolysis using iron oxide catalyst
Authors: Anantharaman Anjana P. , Bangarraju Osipalli , Prakash Chalamala Jaya , Jayabalan Tamilmani 
Published: July 2023

AbstractThe shift in emphasis from fossil fuel‐derived energy to waste‐to‐energy technologies has widened the possibility for environmentally sustainable methods such as pyrolysis. Algae collected from local sources that grow in wastewater using atmospheric CO2 is a potential feedstock for pyrolysis. Thus, the work focuses on studying the pyrolysis reaction of macroalgae sourced from regional sources in the presence of Fe2O3 catalyst using the thermogravimetric analysis, followed by kinetic analysis using iso‐conversional methods of Flynn–Wall–Ozawa (FWO), Kissinger–Akahira–Sunose (KAS), and Starink methods, and model free Kissinger method. The kinetic model was developed using master plot method. XRD analysis of the Fe2O3 catalyst confirms the presence of the maghemite and hematite phases in the sample. Based on the conversion profile, DTG trend, and kinetic parameter variation, the overall pyrolysis process can be divided into three different stages of dissociation reactions. The apparent activation energy calculated from different models varies in the range: stage I (∼268 kJ/mol), stage II (∼261 kJ/mol), and stage III (∼328 kJ/mol), respectively. Master plot analysis of the kinetic data confirms the best fit of the nucleation model (A2) to experimental data in stage II. Further, the thermodynamic properties of the reaction, such as change in enthalpy (ΔH), change in Gibbs free energy (ΔG), and change in entropy (ΔS) range between 206 and 405 kJ/mol, 189 and 651 kJ/mol, −450 and 27 J/mol/K, respectively, corroborates the complexity of the reaction. Kinetics and thermodynamic property analysis of complex reactions like pyrolysis is essential for pilot plant design.
Microbial carbon and nitrogen limitations with mulching of proso millet fields on the Loess Plateau: Evidence from soil ecoenzymatic stoichiometry
Authors: Tian Lixin , Zhang Yuchuan , Gao Xiaoli , Feng Baili 
Published: July 2023

AbstractMulching measures can regulate soil properties; however, little is known about the effects metabolic limitations on farmland during the key growth stages of broomcorn millet in multiple regions of the Loess Plateau. We conducted field experiments to compare three techniques: flat planting with no mulching (TP), ridge–furrow mulching system (RF), and plastic film mulching (PFM). Soil extracellular enzymatic stoichiometry and physicochemical properties of three growth periods (jointing, flowering, and maturity) of proso millet (Panicum miliaceum L.) were measured to investigate microbial metabolic limitations and the relationship with soil moisture, temperature, and nutrients in the three regions of the Loess Plateau (Guyuan city, Huining County, and Yulin city). The results show that compared with TP, both PFM and RF techniques increased soil organic carbon (SOC), total nitrogen (TN), ammonium nitrogen (), and nitrate nitrogen () during the jointing period, but the levels decreased during the flowering period, and the activities of C‐, N‐, P‐acquiring enzymes were 29.02%, 33.68%, and 19.46% higher when using PFM, and 13.78%, 6.81%, and 6.52% higher when using RF. Meanwhile, RF treatment significantly increased the carbon metabolism limitation during the jointing, flowering, and maturity periods of proso millet in the three regions, and also improved the nitrogen metabolism limitation during the jointing and flowering periods of proso millet in the Huining and Yulin regions. Linear regression analysis showed that pH, SOC, and contents significantly affected carbon limitation, and nitrogen limitation was gradually alleviated with increases in SOC, TN, and contents in proso millet farmland soils. Partial least squares path modeling showed that soil moisture and nutrients differed significantly among the regions, and soil temperature positively regulated the soil nutrients. Mulching significantly improved the carbon limitation owing to increased soil temperature and moisture. These results provide important ideas for nutrient cycling and microbial metabolism of broomcorn millet farmland soil under mulching measures on the Loess Plateau.
Spatial and Polarization Division Multiplexing Harnessing On‐Chip Optical Beam Forming
Authors: González‐Andrade David , Le Roux Xavier , Aubin Guy , Amar Farah , Nguyen Thi Hao Nhi , Nuño Ruano Paula , Dinh Thi Thuy Duong , Oser Dorian , Pérez‐Galacho Diego , Cassan Eric , Marris‐Morini Delphine , Vivien Laurent , Alonso‐Ramos Carlos 
Published: July 2023

AbstractOn‐chip spatial and polarization multiplexing has emerged as a powerful strategy to boost the data transmission capacity of integrated optical transceivers. State‐of‐the‐art multiplexers require accurate control of the relative phase or the spatial distribution among different guided optical modes, seriously compromising the optical transmission bandwidth and performance of the devices. To overcome this limitation, a new approach based on the coupling between guided modes in integrated waveguides and optical beams free‐propagating on the chip plane is proposed. The engineering of the evanescent coupling between the guided modes and free‐propagating beams allows spatial and polarization multiplexing with state‐of‐the‐art performance. A two‐polarization multiplexed link and a three‐mode multiplexed link using standard 220‐nm‐thick silicon‐on‐insulator technology have been developed. The two‐polarization link shows a measured −35 dB crosstalk bandwidth of 180 nm, while the three‐mode link exhibits a −20 dB crosstalk bandwidth of 195 nm. These links are used to demonstrate error‐free operation (bit‐error‐rate <10−9) in multiplexing and demultiplexing of two and three non‐return‐to‐zero signals at 40 Gbps each, with power penalties below 0.08 and 1.5 dB for the two‐polarization and three‐mode links, respectively. The approach demonstrated for two polarizations and three modes is transferable to future implementation of more complex multiplexing schemes.
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4‐Related Hereditary Spastic Paraplegia
Authors: Alecu Julian E. , Saffari Afshin , Ziegler Marvin , Jordan Catherine , Tam Amy , Kim Soyoung , Leung Edward , Szczaluba Krzysztof , Mierzewska Hanna , King Staci D. , Santorelli Filippo M. , Yoon Grace , Trombetta Bianca , Kivisäkk Pia , Zhang Bo , Sahin Mustafa , Ebrahimi‐Fakhari Darius 
Published: July 2023

AbstractBackgroundAdaptor protein complex 4‐associated hereditary spastic paraplegia (AP‐4‐HSP) is caused by pathogenic biallelic variants in AP4B1, AP4M1, AP4E1, and AP4S1.ObjectiveThe aim was to explore blood markers of neuroaxonal damage in AP‐4‐HSP.MethodsPlasma neurofilament light chain (pNfL) and glial fibrillary acidic protein (GFAP) levels were measured in samples from patients and age‐ and sex‐matched controls (NfL: n = 46 vs. n = 46; GFAP: n = 14 vs. n = 21) using single‐molecule array assays. Patients' phenotypes were systematically assessed using the AP‐4‐HSP natural history study questionnaires, the Spastic Paraplegia Rating Scale, and the SPATAX disability score.ResultspNfL levels increased in AP‐4‐HSP patients, allowing differentiation from controls (Mann‐Whitney U test: P = 3.0e‐10; area under the curve = 0.87 with a 95% confidence interval of 0.80–0.94). Phenotypic cluster analyses revealed a subgroup of individuals with severe generalized‐onset seizures and developmental stagnation, who showed differentially higher pNfL levels (Mann‐Whitney U test between two identified clusters: P = 2.5e‐6). Plasma GFAP levels were unchanged in patients with AP‐4‐HSP.ConclusionspNfL is a potential disease marker in AP‐4‐HSP and can help differentiate between phenotypic subgroups. © 2023 International Parkinson and Movement Disorder Society.
A preparation pulse for fast steady state approach in Actual Flip angle Imaging
Authors: Zampini Marco Andrea , Sijbers Jan , Verhoye Marleen , Garipov Ruslan 
Published: July 2023

AbstractBackgroundActual Flip angle Imaging (AFI) is a sequence used for B1 mapping, also embedded in the Variable flip angle with AFI for simultaneous estimation of T1, B1 and equilibrium magnetization.PurposeTo investigate the design of a preparation module for AFI to allow a fast approach to steady state (SS) without requiring the use of dummy acquisitions.MethodsThe features of a preparation module with a B1 insensitive adiabatic pulse, spoiler gradients, and a recovery time were studied with simulations and validated via experiments and acquired with different k‐space traveling strategies. The robustness of the flip angle of the preparation pulse on the acquired signal is studied.ResultsWhen a 90° adiabatic pulse is used, the forthcoming can be expressed as a function of repetition times and AFI flip angle only as , where n represents the ratio between the two repetition times of AFI. The robustness of the method is demonstrated by showing that using the values further away from 90° still allows for a faster approach to SS than the use of dummy pulses.ConclusionsThe preparation module is particularly advantageous for low flip angles, as well as for AFI sequences that sample the center of the k‐space early in the sequence, such as centric ordering acquisitions, and for ultrafast EPI‐based AFI methods, thus allowing to reduce scanner overhead time.
Bullied: Exploring the concepts of territorialism and groupthink involvement in workplace bullying
Authors: Green Cheryl , Dimino Luong Ada 
Published: July 2023

AbstractAimsTo educate nurse managers on territorialism and groupthink as being factors within workplace bullying among nurses within the clinical and academic settings that can psychologically and physically harm affected persons.DesignTerritorialism and groupthink are explored as being factors within workplace bullying used by a bully or bullies to target others for personal gain and power. Workplace bullying has become habitual practice in nursing and nursing academia. Workplace bullying is identified not only as unethical behaviour but also as a dangerous practice that can lead to depression, anxiety, stress, and posttraumatic distress syndrome. Persons affected are subjected to emotional abuse that can lead to isolation, low self‐esteem, and self‐doubt.MethodsMethods by which persons in the workplace can identify bullying that involves territorialism and groupthink are examined. Nurse managers are identified as being instrumental in the identification of workplace bullying involving territorialism and groupthink, and in working with the affected person(s) and bully or bullies to seek mediation through a human resource representative. For nursing managers, it is imperative that workplace bullying is immediately addressed. Workplace bullying creates a hostile and intimidating working environment that affects the physical and mental health of affected persons.ResultsEarly identification and resolution of workplace bullying could alleviate the development of physiological and psychological health problems by affected persons. After workplace bullying has been reported, the affected persons should focus on the healing of mind, spirit, and body. New circumstances (e.g., a new place of employment or a promotion) may trigger feelings of anger, intimidation or fear; therefore, it' is important for persons who have experienced bullying in the workplace to understand the abusive environment itself was not directly associated with any wrongdoing by them.No Patient or Public ContributionWorkplace bullying is disruptive to the workplace and affects productivity, absenteeism from work and turnover intentions. Persons impacted by territorialism and groupthink within the context of workplace bullying can develop psychological and physiological health problems.
Selective C‐7 Functionalization of Phenanthridines by Microwave‐Assisted Claisen Rearrangements of 8‐Allyloxyphenanthridines
Authors: Lepsøe Mathias Ryslett , Dalevold Aleksander Granum , Gundersen Lise‐Lotte 
Published: July 2023

AbstractCarbon‐carbon bond formation in the phenanthridine 7‐position was achieved by microwave‐assisted Claisen rearrangement of 8‐allyloxyphenanthridines. The reactions took place with excellent regioselectivity and high chemical yields. If the 7‐position was substituted, rearrangement to C‐9 took place, but the reaction occurred less readily. Rearrangements of 8‐allyloxy‐5,6‐dihydrophenanthridines (phenanthridines with a saturated B‐ring) gave a mixture of 7‐ and 9‐substituted products. The experimental results were supported by DFT (density functional theory) calculations.