bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Media Pembelajaran Berbasis Sensory Carpet Untuk Pemahaman Panca Indera Anak Usia 1-2 Tahun
Authors: Wahyuningtyas Dessy Putri , Roziah Rifqoh 
Published: July 2023

Penelitian ini bertujuan untuk: 1) mengembangkan alat permainan edukatif (APE) bagi anak usia 1-2 tahun berupa media sensory carpet; 2) menerapkan media sensory carpet yang menunjang pemahaman panca indera anak. Penelitian pengembangan (Research and Development) ini mengacu pada model pengembangan Borg and Gall. Langkah yang dilakukan peneliti meliputi pengumpulan informasi awal, perencanaan, pengembangan produk awal, uji coba validasi ahli, revisi hasil uji coba validasi ahli, uji coba lapangan awal, revisi hasil uji coba lapangan awal, uji coba lapangan dan penyempurnaan produk akhir. Hasil penilaian ahli materi diperoleh rata-rata skor 4,08 dan penilaian ahli media memperoleh rata-rata skor 4,62. Setelah melakukan uji coba lapangan, peneliti memperoleh presentase skor sebesar 91,66%. Sehingga dapat disimpulkan bahwa media sensory carpet untuk pemahaman panca indera anak usia 1-2 tahun ini dinyatakan layak digunakan.
THE EFFECT OF PROJECT BASED LEARNING ON SCIENCE PROCESS SKILLS IN EARLY CHILDREN
Authors: Farantika Dessy , Indrawati Dwi , Shofwan Arif Muzayin , Setyowati Rina Insani 
Published: July 2023

The results of preliminary observations indicate that learning still uses Project Based Learning Model Learning. So that the child's ability to speak is still lacking, especially telling the contents, communicating with simple words, expressing ideas, retelling the story according to the flow. The right learning model to stimulate children's speaking ability is Project Based Learning assisted by big books, because project learning is carried out in groups and uses big book media so that it can stimulate children's speaking abilities. The purpose of this study was to determine the differences in group learning outcomes using the Project Based Learning model assisted by big books and the Project Based Learning class groups on speaking skills. The study design uses quasi-experimental research. The subjects in this study were all children of group B in TK Al-Muhajirin Malang in the 2018/2019 academic year even semester which consisted of two classes namely B1 totalling 17 children as an experimental class and B2 totalling 17 children as a control class, using purposive sampling. The prerequisite test used in this study was the construct validation test with 3 validators, namely one lecturer as a learning expert, one lecturer as a media expert, and one school principal as a practitioner to assess the validity level of the Daily Learning Implementation Plan (RPPH) and an observation sheet of participants' speaking skills students using big book.
EKSTRAKSI PROTEIN DARI SPIRULINA SP DALAM PELARUT ETANOL TERBANTUKAN GELOMBANG ULTRASONIK
Authors: Fachri Boy Arief , Palupi Bekti , Rahmawati Istiqomah , Rizkiana Meta Fitri , Amini Helda Wika 
Published: July 2023

Protein merupakan komponen nutrisi yang dibutuhkan oleh manusia untuk kesehatan tubuh. Salah satu sumber protein yang melimpah di Indonesia adalah alga Spirulina Sp. Ekstraksi protein alga, sulit dilakukan. Hal ini dikarenakan, protein tersimpan dalam sel-sel alga yang memiliki dinding yang sangat keras. Metode konvensional yang selama ini dilakukan membutuhkan waktu yang sangat lama, dan energi yang besar. Untuk mengatasi hal itu, sebuah metode alternatif yang diajukan dalam penelitian ini, adalah metode ekstraksi ultrasonik. Tujuan penelitian ini adalah untuk menentukan kondisi optimum ekstraksi protein dari Spirulina Sp dan mengetahui pengaruh parameter ekstraksi terhadap yield. Sprirulina Sp yang tekah dikeringkan dan dihaluskan diumpankan ke dalam ekstraktor yang berisi etanol. Gelombang ultrasonic, kemudian dialirkan ke dalam ekstraktor melalui probe. Setelah, eaktu ekstraksi tercapai, ekstrak dan residu dipisahkan dengan cara sentrifugasi dengan kecepatan 10000 rpm pada suhu kamar. Selanjutnya, yield protein ekstrak dihitung dengan analisa Lowry-Bradford. Pengaruh parameter proses seperti rasio bahan baku-pelarut (0:1-0.5) g/mL, ukuran partikel bahan baku (600-800) mesh dan waktu ekstraksi 15-45 menit) terhadap yield akan diamati dalam penelitian ini. Berdasarkan hasil penelitian, dapat disimpulkan bahwa yield tertinggi sebesar 80,87 % diperoleh pada kondisi rasio bahan baku-pelarut 0.2 g/mL, ukuran partikel bahan baku 700 mesh dan waktu ekstraksi 30 menit. Sementara itu, ukuran partikel merupakan parameter yang paling signifikan.
Hubungan Tingkat Pendidikan terhadap Pengetahuan pada Pedagang Tahu Putih tentang Kandungan Formalin di Pasar Tradisional Kota Surabaya
Authors: Khanif Ashlikhatul , Mahmudiono Trias 
Published: July 2023

Latar Belakang: Tahu menjadi makanan alternatif yang dikenal lezat dan bergizi, namun memiliki daya simpan yang singkat. Pedagang menggunakan formalin sebagai pengawet karena lebih hemat, lebih murah, dan mudah didapatkan. Formalin jika dikonsumsi terus menerus dapat menyebabkan gangguan kesehatan. Penggunaan formalin pada tahu dapat disebabkan karena kurangnya pengetahuan terhadap bahaya formalin. Pengetahuan seseorang dapat dipengaruhi oleh pendidikan seseorang.
Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan tingkat pendidikan terhadap pengetahuan pada pedagang tahu putih tentang kandungan formalin di pasar tradisional Kota Surabaya
Metode: Penelitian dilaksanakan pada 31 Mei-13 Juni 2022 di pasar tradisional Surabaya. Jenis penelitian ini adalah observasional analitik dengan pendekatan cross-sectional. Sampel penelitian sebanyak 46 pedagang diambil menggunakan teknik multistage random sampling. Wawancara menggunakan kuesioner berisi 12 pertanyaan pilihan ganda. Uji kualitatif kandungan formalin menggunakan MQuant Formaldehyde Test. Analisis statistik menggunakan uji chi-square dengan signifikansi 0,05.
Hasil: Hasil penelitian ini menemukan bahwa sebagian besar pedagang memiliki tingkat pendidikan terakhir SD-SMP (60,9%) dan pengetahuan yang kurang mengenai formalin (41,3%). Hasil uji kualitatif menunjukkan tidak terdapat sampel tahu yang mengandung formalin (100%).
Kesimpulan: Terdapat hubungan yang bermakna antara tingkat pendidikan terhadap tingkat pengetahuan pedagang tahu putih mengenai kandungan formalin di pasar tradisional Kota Surabaya (p=0,043).
The Relationship Between Family Smoking Habits and the Use of Room Perfume with Complaints of Allergic Rhinitis in Children Aged 13-14 Years in Rungkut District, Surabaya City
Authors: Fakhry Muhammad Aziz Al , Prasasti Corie Indria 
Published: July 2023

ABSTRACT

Background: Allergic rhinitis is defined clinically as a symptom of nasal hypersensitivity triggered by a certain allergen present in the environment. The prevalence of allergic rhinitis has increased over the past 5 years. Indoor air quality is influenced by the number of pollutants according to the place, climate, culture, local ambient air, characteristics of buildings and indoor activities.
Objectives: To analyze the relationship between family smoking habits and room perfume use with complaints of allergic rhinitis in children aged 13-14 years in Rungkut District, Surabaya City.
Methods: This research method was quantitative research with an analytical type of observational research with a cross-sectional research design. The sample size in this study was 94 children aged 13-14 years and the sample was taken using systematic random sampling. Data collection by conducting interviews, observations and measurements directly. The test used is chi-square
Results: There was a relationship between family smoking habits and complaints of allergic rhinitis in children (p = 0.000) and there was a relationship between the use of room perfume and complaints of rhinitis in children (p = 0.029).
Conclusion: Family smoking habits and the use of room perfume have a significant relationship with complaints of allergic rhinitis in children. Families are encouraged to eliminate smoking and minimize the use of room perfume in order to minimize risk factors for complaints of allergic rhinitis in children.
ЕКСПЕРИМЕНТАЛЬНИЙ КОМПЛЕКС ДЛЯ ДОСЛІДЖЕННЯ НЕЙРОФІЗІОЛОГІЧНИХ ХАРАКТЕРИСТИК ПРИ РІЗНИХ ФОРМАХ ТРЕНУВАННЯ ЛУЧНИКІВ
Authors: Литвякова Дарина , Овчаренко Ганна , Білошицька Оксана 
Published: July 2023

В роботі запропоновано інструментальній метод кількісної оцінки психологічної підготовки спортсменів, а особливо – стрільців, оскільки було помічено, що при бездоганній ззовні техніці виконання пострілу поставлені результати не досягаються. Безліч помилок психологічного характеру знайдено та описано у всіх видах спорту, проте лише за наявності об’єктивних методів діагностики можна говорити про точні вказівки та інструкції при підготовці спортсменів. До цих пір виявлення помилок такого роду залежало лише від тренерського досвіду та таланту. Для об’єктивізації виявлення помилок запропоновано використовувати ЕЕГ. При наявності чіткого алгоритму щодо аналізу та використання ЕЕГ в цілому кожен спортсмен зможе самостійно зрозуміти свої помилки. Та й невірне тлумачення буде більш малоймовірним. Крім того, вивчення ЕЕГ дає змогу більш глибоко зрозуміти процеси, що відбуваються в спортсмені в момент виконання пострілу. Це може відкрити нові напрями удосконалення техніки, що, в свою чергу, дасть принципово новий результат.
В ході роботи було виконано візуальний аналіз ЕЕГ, домінуючих та суб-домінуючих ритмів у стрільців, а також картування. Проведено аналіз вкладів ритмів з допомогою критеріїв Краскела-Уолліса та Манна-Уітні. На основі отриманих результатів дано чіткі методи визначення шістьох основних помилок в стрільбі з луку (зацілювання, підловлювання точки прицілювання, очікування пострілу, втрата концентрації, невідповідність перенесення уваги з алгоритмом та невірне виконання ідеомоторного тренування). Знайдено «мічені ритми», за допомогою яких можна контролювати проходження уявного тренування. Також виявлено домінантність дельта- та тета-ритмів, що говорить про глибоку зажуреність спортсмена у відчуття власного тіла, а не навколишнього світу. При цьому не виявлено впливу прицілювання на роботу мозку, що говорить про паралельність цієї дії основному алгоритму
Closed-Loop O2 Use During Invasive Mechanical Ventilation of Pediatric Patients (CLOUDIMPP): A Randomized Cross-Over Study
Authors: Atakul Gulhan , Ceylan Gokhan , Sandal Ozlem , Soydan Ekin , Topal Sevgi , Colak Mustafa , Hepduman Pinar , Karaarslan Utku , Zimmerman Jan , Novotni Dominik , Agin Hasan 
Published: July 2023

Abstract
Oxygen is an effective treatment for any type of respiratory failure. To prevent hypoxemia and hyperoxemia, the Pediatric mechanical ventilation consensus conference (PEMVECC) recommends monitoring oxygen saturation with pulse oximetry (SpO2) in all ventilated children and measuring partial arterial oxygen pressure (PaO2) in moderate to severe cases. However, this may require manual adjustments of inspired oxygen, which can be burdensome during high-demand periods such as the current COVID-19 epidemic. Additionally, the pandemic has highlighted the importance of optimizing oxygen use in hospitals as it may become a scarce resource during such high-demand periods. Previous studies have shown that automatic oxygen titration (AOT) is feasible in patients receiving respiratory support therapy, including those with mild acute hypoxemic respiratory failure and exercise-induced desaturation. This study aims to assess the safety and efficacy of a closed-loop FiO2 controller in comparison to traditional manual FiO2 regulation during invasive mechanical ventilation (IMV) in pediatric patients within a pediatric critical care unit (PICU). The hypothesis is that the closed-loop FiO2 controller will increase the time spent within clinically intended SpO2 ranges and decrease the time spent outside these ranges. The research is registered under NCT05714527
A systematic review and meta-analysis on endothelial dysfunction post-shock resuscitation
Authors: Obonyo Nchafatso , Sela Declan , Raman Sainath , Rachakonda Reema , Schneider Bailey , Hoe Louise See , Fanning Jonathon , Bassi Gianluigi Li , Maitland Kathryn , Suen Jacky , Fraser John 
Published: July 2023

Abstract
Introduction
Shock-induced endotheliopathy (SHINE), defined as a profound sympathoadrenal hyperactivation in shock states leading to endothelial activation, glycocalyx damage, and eventual compromise of end-organ perfusion, was first described in 2017. The aggressive resuscitation therapies utilised in treating shock states could potentially lead to further worsening endothelial activation and end-organ dysfunction.
Objective
This study aimed to systematically review the literature on resuscitation-associated and resuscitation-induced endothelial dysfunction.
Methods
A pre-determined structured search of literature published over an eleven-year period (1 January 2011 to 31 December 2022) was performed in two indexed databases (PubMed/MEDLINE and EMBASE) per PRISMA guidelines.
Results
Thirty studies met the inclusion criteria and were included in the final qualitative synthesis. Most of these studies (43%) reported on a combination of mediators released from endothelial cells and biomarkers of glycocalyx breakdown, while only 20% reported on microvascular flow changes. Only eight individual studies were included in the quantitative meta-analysis based on the comparability of the parameters assessed. Six studies measured syndecan-1, with a heterogeneity index, I2 = 75.87% (pooled effect-size; z = 2.00; mean = 0.43; 95% CI 0.01 to 0.85; p = 0.05). Thrombomodulin was measured in 4 comparable studies (I2 = 78.93%; z = 1.57; mean = 0.41; 95% CI -0.10 to 0.92; p = 0.12).
Conclusion
Acute resuscitation therapies administered could exacerbate endothelial dysfunction in shock states. In the included studies, syndecan-1 had the highest frequency of assessment in the post-resuscitation period and changes in concentrations showed a statistically significant effect of the resuscitation. There are inadequate data available in this area and further research and standardisation of the ideal assessment and panel of biomarkers are urgently needed.
DEAr – Differential Expression Analyzer
Authors: Karpenko Dmitriy 
Published: July 2023

Abstract
Differential expression of genes is one of the key features of modern biology for cells and tissues. To present differential expression from real time PCR data, the expression of housekeeping genes is considered as a baseline. There are solutions available to help verify that the genes provided are stable enough to be used as a reference. But sometimes, we struggle to find genes that are stable for the required cells and conditions. Here I present a program that simultaneously checks expressions of all genes and selects the most stable as a baseline for the less stable. Differential Expression Analyzer (DEAr) assigns weights to all values depending on accuracy of direct measurements and reproducibility of differential expressions in the dataset, at the same time the program utilizes external knowledge about stability or instability of genes in considered materials and contributes it to weights as well. The algorithm is based on recursive computations that are described in detail in the article. DEAr is packaged in an executable file for the OS Windows. DEAr takes and returns data in Excel format, so no programming skills are required for fast, automated analysis of differential expression.
Validation of the volumetric flow cytometry for bovine sperm concentration
Authors: Gloria Alessia , Bracco Claudia , Antenucci Emiliana , Contri Alberto 
Published: July 2023

AbstractSperm concentration is a stronghold of the andrological evaluation and the production of insemination doses. The use of haemocytometers, although considered the gold standard, is difficult to apply in field conditions because subjective and time-consuming. The present study was designed to validate the volumetric flow cytometry to estimate sperm concentration, comparing it with the performances of haemocytometer, NucleoCounter, and flow cytometry using fluorospheres. Compared with other methods, volumetric flow cytometry appeared less affected by large dilution of the sample, with similar concentrations calculated in the range of dilution 1:200 to 1:800. Using volumetric flow cytometry the population detected using morphological criteria and fluorescence of DNA better represents the real concentration of sperm in the sample. Volumetric flow cytometry showed high repeatability compared with the haemocytometer (coefficient of variation 1.85% and 4.52%, respectively). Finally, volumetric flow cytometry showed stable performances in cryopreserved samples analysis, with negligible effects of the medium components and cryoprotectants. The present study showed that volumetric flow cytometry is an accurate and precise method to estimate sperm concentration in bovine fresh and frozen semen, making possible the quantification of sperm functional subpopulation. This implements the possibility to study the relationship between sperm attributes and fertility.
The influence of reaction temperature and surfactant on the magnetic and catalytic properties of FeCo nanoparticles
Authors: Liao Tianfa , Wei Xiaohui , Xin Canjie , Yang Fujun 
Published: July 2023

Abstract
FeCo nanoparticles were prepared by controlling the reaction temperature and addition of surfactant. With the increasing of reaction temperature, CoFe2O4 impurities disappeared and crystalline FeCo nanoparticles were got. High Ms of 218.5 emu/g and low Hc of 90.2 Oe were observed after reacting at 150 oC. The best OER (oxygen evolution reaction) properties with low onset potential (0.73 V) and small Tafel value (105 mV/dec) were found in FeCo nanoparticles prepared at 150 oC. With increasing the surfactant ratio, the purity of FeCo particles did not change. However, the repulsive forces between the polar ends of oleic acid molecules induced the formation of uniform small FeCo nanoparticles. Large Ms of 166.4 emu/g and small Hc of 75.0 Oe were observed when the surfactant ratio was 3:1. The best OER activity with low onset potential (0.63 V) and small Tafel value (67 mV/dec) were found in FeCo nanoparticles prepared with the surfactant ratio of 3:1. The improved OER activity was contributed to the impurity reduction, the better crystallization, the larger surface area and the better magnetic properties, which could provide small electric resistance, more active sites and easy electron transfer.
Progesterone long-acting injection for assisted reproduction: Formulation and in vivo pharmacokinetic behavior
Authors: Li Li , Li Ming , Wei Wei , Yi Cong , Su Zhengxing , Zhao Dong 
Published: July 2023

Abstract
Progesterone (PG) is a key hormone that maintains the normal physiology of female reproductive system. However, due to its insolubility, the drugs used for assisted reproduction in clinical are mainly oil injections, patients with multiple injections are prone to adverse reactions such as redness, pain, induration and even muscle necrosis. In this study, we developed the progesterone long-acting injection which was administered every 7 days and could substantially reduce injection-site adverse reactions after long term administration. The progesterone long-acting injection containing 20% (w/v) progesterone was first prepared using solvent–antisolvent precipitation method. The particle size, X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and in vitro dissolution were carried out to evaluate the characteristics. The results showed that the particle size of the progesterone long-acting injection was Dv10 8.128µm, Dv50 15.457µm, DV90 26.942µm and the crystal form was form α. In addition, the physical stability was also investigated after storage for 6 months at 40℃ and no obvious change in particle size was observed and the sample resuspension was well, indicating that the selected formulation was reasonable. The in vivo toxicology studies and pharmacokinetics tests showed that the progesterone long-acting injection had lower irritation than progesterone oil injection and could achieve sustained release for 7 days with a flat trend in plasma concentrations. Therefore, it was obvious that the progesterone long-acting injection we designed exhibited a lower muscle irritation and longer release period, which could be a better dosage form than progesterone oil injection and significantly increase patient compliance.
Recent innovations in fertilization with treated digestate from food waste to recover nutrients for arid agricultural fields
Authors: Skrzypczak Dawid , Trzaska Krzysztof , Mironiuk Małgorzata , Mikula Katarzyna , Izydorczyk Grzegorz , Polomska Xymena , Wiśniewski Jerzy , Mielko Karolina , Moustakas Konstantinos , Chojnacka Katarzyna 
Published: July 2023

Abstract
This study aims to explore the development of sustainable fertilizers from waste materials of a biogas plant and a brewery. These wastes, rich in organic carbon and nitrogen, were processed with sulfuric(VI) and phosphoric(V) acid mixture, facilitating the production of free amino acids and achieving waste sanitization. This treatment produced by-products, which extended the range of possible applications. The highest concentration of free amino acids (360 mg/L) was achieved through hydrolyzing with a 40% concentration medium over 24 hours. The study presents two fertilizer technologies, with and without micronutrients, that satisfy European Parliament Regulation 2019/1009 (Ntot>2%, Norg>0.5%, Corg>3%). Bioavailability of nutrients in the formulations ranged from 60% to 100%. The efficacies of these fertilizers were evaluated in 30-day pot trials with various plant species, with both single application and fertigation tested. Multielement analysis confirmed high nutrient transfer in the soil-plant system, and the inclusion of micronutrients led to biofortification of plant biomass in Cu, Mn, Zn, and Fe. These sustainable fertilizers present an alternative to traditional, non-renewable fertilizers and offer promising solutions for precision agriculture and environmentally conscious production.