bluuebunny/crossref_metadata_2025_split huggingface dataset:
Title: Assessing Energy Performance Improvement Potential of Traditional Housing in North-Eastern India through Building Energy Simulation
Authors: Thakur Biswajit , Roy Souvanic , Sen Bedshruti , Paul Krishnendu , Pal Rituparna 
Published: February 2023

Abstract

The building sector is a principal consumer of energy globally, and in India, the residential buildings have second highest energy demands after the industrial sector. Improving energy performance of residential houses will considerably curtail the associated carbon emissions. Compared to energy intensive urban buildings, research on energy modeling receives scant attention for small and moderate size non-engineered, traditional and naturally ventilated residential buildings constructed with low embodied energy local materials using semi-skilled construction techniques. As majority of the residential buildings in the towns and rural areas in the North-Eastern states of India are primarily constructed with such materials, the existing literature review calls for a quantitative assessment of their energy consumption patterns along with contributions of various building envelope parameters. The article aims to assess the improvement potential of the Energy Performance Index (EPI) of traditional houses in three locations viz. Agartala, Jorhat and Shillong and examine the roles of various building parameters and material options in influencing the EPI through whole building energy simulation technique followed by sensitivity analysis. The resulting optimum combinations have shown the EPI improvement (reduction) potential of 19.27 %, 21.40 %, 27.42 % over the worst cases, respectively for Agartala, Jorhat and Shillong buildings. The sensitivity analysis identified building geometry parameters such as Volume, Wall Area, Surface Area, Carpet Area and Building Height to critically influence the energy performance.
Efficacy and safety of a self-improved continuous bladder irrigation sensor device in patients after transurethral resection of the prostate: a prospective study
Authors: Tao Rong-zhen , Li Ai , Su Shu , Tang Qing-lai , Mao Juan-juan , Zhou Shuang 
Published: February 2023

Abstract
Objective
To explore the efficacy and safety of a self-improved continuous bladder irrigation (CBI) sensor device after transurethral resection of the prostate (TURP).
Patients and Methods
A total of 160 patients with benign prostatic hyperplasia who received TURP from June 2021 to May 2022 were selected. According to the envelope randomization method, patients were divided into a control group (80 cases) and study group (80 cases). In the control group, the speed of bladder flushing fluid was adjusted according to the clinical experience of nurses. On the basis of the control group, the self-improved CBI sensor device was used in the study group to observe the postoperative comfort and complication rate in the two groups.
Results
The comfort of patients in the study group was significantly higher than that of patients in the control group (97.50% vs. 88.75%, P =0.023), and the number of postoperative complications in the control group was significantly higher than that in the study group (8.75% vs. 1.25%, P=0.021). Meanwhile, the average amount of irrigation fluid in the study group was obviously lower than that in the control group (26.4 L vs. 27.8 L, P =0.011). In addition, patients in the study group had a significantly shorter hospital stay than the controls (3.3 days vs. 3.6 days, P =0.005).
Conclusions
Implementation of the new self-improved CBI sensor device for patients after TURP can improve their awareness regarding disease-related knowledge, alleviate their fear and anxiety, improve their compliance and comfort with treatment and nursing, and reduce the incidence of complications.
Tracking supercritical geothermal fluid distribution from continuous seismic monitoring
Authors: Andajani Rezkia Dewi , Tsuji Takeshi , Ikeda Tatsunori , Matsumoto Satoshi , Kitamura Keigo , Nishijima Jun 
Published: February 2023

Abstract
Continuous seismic monitoring could play a pivotal role in deep geothermal energy exploration. We monitored seismicity near geothermal production areas of the Kuju volcanic complex with a dense seismic network and automated event detection. Most events were shallow (less than 3 km below sea level) and distributed along a boundary between regions of high and low resistivity and S-wave velocity, interpreted as a lithological boundary or related fracture zone. Deeper events located on top of subvertical conductors may reflect fracturing associated with magmatic fluid intrusion. We attribute a possible correlation between seismicity and heavy rainfall three days prior to increased pore pressure in pre-existing fractures. Our findings support the presence of supercritical geothermal fluids and demonstrate the importance of continuous seismic monitoring in supercritical geothermal energy exploration.
Nutrients, extractable bound phenolic compositions and their antioxidant properties in different varieties of mung beans
Authors: Zhao Jiaying , Wu Xin , Song Xiaoxiao , Lin Haifeng , Yin Junyi , Nie Shaoping , Xie Mingyong 
Published: February 2023

Abstract
Mung beans are traditional medicine and food homologous crops in China, widely planted and welcomed by consumers. In this work, we compared the nutrient compositions (including moisture, ash, protein, dietary fiber, amino acids and fatty acids) of 7 kinds of mung beans, qualitative and quantitative identified phenolic compounds in their methanol extracts by UPLC-ESI-QTOF-MS and HPLC-ESI-QQQ-MS/MS, as well as their antioxidant properties. The protein (20–25%) was the main nutritional component and the contents of phenolic compounds in mung beans varied from 1.1 to 2.6 mg/g, which was correlated with antioxidant activity in vitro. A total of 22 compounds were detected from the methanol extracts. The quantitative results of phenolic compounds in mung beans showed that vitexin content was the highest, while naringin content was the lowest. Therefore, mung beans are rich in phytochemicals and excellent source of dietary antioxidant polyphenols. It can help people prevent and control many chronic diseases.
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes
Authors: Hyster Todd , Page Claire , Cao Jingzhe , Oblinsky Daniel , MacMillan Samantha , Dahagam Shiva , Lloyd Ruth , Charnock Simon , Scholes Gregory 
Published: February 2023

Abstract
Substituted arenes are ubiquitous in molecules with medicinal functions, making their synthesis a critical consideration when designing synthetic routes.1,2 Regioselective C–H functionalization reactions are attractive for preparing alkylated arenes,3-5 however, the selectivity of existing methods is modest and primarily governed by substrate electronic properties.6,7 Here, we demonstrate a biocatalyst-controlled method for the regioselective alkylation of electron-rich and electron-deficient heteroarenes. Starting from an unselective ‘ene’-reductase (ERED) (GluER-T36A), we evolved a variant that selectively alkylates the C4 position of indole, an elusive position using prior technologies. Mechanistic studies across the evolutionary series indicate that changes to the protein active site alter the electronic character of the charge transfer (CT) complex responsible for radical formation. This resulted in a variant with a significant degree of ground state change transfer in the CT complex. Mechanistic studies on a C2 selective ERED suggest that the evolution of GluER-T36A helps disfavor a competing mechanistic pathway. Additional protein engineering campaigns were carried out for a C8 selective quinoline alkylation. This study highlights the opportunity to use enzymes for regioselective reactions where small molecule catalysts struggle to alter selectivity.
A Rare Case of Intraosseous Papillary Hemangioma of the Head and Neck
Authors: Geetha Saroja D , Abdelwahed Mohammed , Edelman Morris C. , Buyuk Arzu , Gordon David , Rishi Arvind 
Published: February 2023

Abstract
Objectives
Papillary hemangioma (PH) is a novel variant of intravascular capillary hemangioma. It is more common in adults and has a male predominance. Most tumors reported so far are solitary and cutaneous. Here we present a rare case of an intraosseous PH involving the frontal bone.
Methods
Brain imaging in a 69-year-old male with a slowly enlarging swelling on the right frontal area following an accidental fall demonstrated a 4.5 cm x 1.7 cm x 4.2 cm mass originating from the right frontal bone, with a tiny defect on the orbital roof. A malignant process was favored, and the mass was removed.
Results
Histopathology revealed a vascular lesion showing intraosseous distribution with foci of extension into the fibrous connective tissue. There were areas of plump endothelial cells with intracytoplasmic hyaline globules arranged in papillary configuration. The lesional cells were immunoreactive with CD34 and vimentin. AE1/AE3, EMA, PR, D2-40, inhibin and S100 stains were negative. Ki-67 was low.
Conclusion
This is the first intraosseous and second non-cutaneous PH. Clinically it differs from other cases by the presence of trauma as a preceding event. Since its prognosis is unknown such patients should be monitored for recurrence or malignant transformation.
WITHDRAWN: A robust method for heart sounds classification based on empirical mode decomposition adaptive reconstruction.
Authors: Chen Yi , Liu Ming , Wang Yu , Fan Hongtao , Sun Yaojie 
Published: February 2023

Abstract
Background: Heart sound signal analysis is an important method for noninvasive diagnosis of cardiovascular disease. In addition, an effective heart sound classification is an important prerequisite for heart sound analysis. Therefore, the classification of heart sound is of significant value.
Methods: In view of ambient noise and pathologic features of heart sounds are the main unavoidable interference in heart sounds classification. This paper presents a new method for heart sounds correction and classification based on empirical mode decomposition (EMD) adaptive reconstruction. Firstly, since the noise reduction effect of EMD depends on the selection of intrinsic mode function (IMF), the signal-to-noise ratio (SNR) as an evaluation index of noise reduction effect was taken, and the selection of IMF was optimized based on it. Secondly, in order to reduce the false screening of peak points, the traditional single threshold method was improved by introducing a second threshold. Afterwards, the peak points were screened by the two-step threshold method. Finally, a heart sound correction algorithm for correcting the false components was proposed. Based on this, the heart sound signals were classified by the time domain characteristics.
Results: The experimental results show that the localization has a detection sensitivity (Se) of 97.32%, a correct detection rate (P) of 99.19% and algorithm evaluation score (F1) of 0.982. Moreover, the Se, P and F1 of component classification reach 94.93%, 96.27% and 0.956, respectively.
Conclusion: The test results show that the heart sound correction algorithm can effectively distinguish the difference between heart sounds and murmurs, correct the errors caused by pathologic conditions, and accurately locate and classify heart sounds.
Molecular mechanism of selective adsorption and separation of n-butane/i-butane on MFI zeolite
Authors: Wang Huan , Li Qiang , Zhang Li , Qin Yucai , Xu Jianan , Liu Honghai , Sun Zhaolin , Song Lijuan 
Published: February 2023

Abstract
MFI zeolite is one of the most attractive molecular sieve materials for selective adsorption and separation of C4 hydrocarbon isomers. The correlation of channel structure and adsorption thermodynamics and kinetic behavior of butane isomers has been explored using Grand Canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations. The results of single com-ponent and binary competitive adsorption isotherms of n-butane/i-butane at 273 K, 303 K, 343K, and 373 K substantiated the excellent low pressure loading and adsorption selectivity for n-butane on MFI zeolite. The density distribution maps and the RDFs data revealed that there are different preferential adsorption sites for n-butane and i-butane molecules in MFI zeolite. Due to the van der Waals repulsion occurring, the adsorption energy of i-butane is less than that of n-butane, which makes that i-butane cannot be apt to be adsorbed in the two channels, but preferentially in the cross channel of MFI zeolite. Moreover, the mean square displacement (MSD) and calculated diffusion coefficient proved that the diffusion rate of n-butane is faster than that of i-butane by more than two orders of magnitude. These findings clarify the molecular mechanism of selective adsorption and separation of n-butane/i-butane on the rational designed MFI zeolite-based materials.
A pan-cancer analysis of USP5: its diagnostic, prognostic and immunological roles in human cancers
Authors: Yan Bokang , Guo Jiaxing , Deng Shuang , Chen Dongliang , Huang Meiyuan 
Published: February 2023

Abstract
Background
Posttranslational modifications (PTM) of proteins, such as acetylation, deubiquitination, and phosphorylation play important roles in various kinds of cancer progression. Ubiquitin-specific proteinase 5 (USP5), a unique member of deubiquitinating enzymes (DUBs) which recognizes unanchored polyubiquitin specifically, could regulate the stability of many tumorigenesis-associated proteins to influence cancer initiation and progression. However, the diverse biological significance of USP5 in pan-cancer has not been systematically and comprehensively studied.
Methods
Here, we explored the role of USP5 in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database, and we also acquired and analyzed data via various software and web platforms such as R, GEPIA2.0, HPA, TISIDB, cBioPortal, UALCAN, TIMER 2.0, CancerSEA and BioGRID.
Results
USP5 expression was high in most cancers and differed significantly in different molecular and immune subtypes of cancers. In addition, USP5 had certain diagnostic value in multiple cancers, and high expression of USP5 generally predicted poor prognosis for cancer patients. We also found that the most frequent genetic alterations type of USP5 was mutation, and the DNA methylation level of USP5 decreased in various cancers. Furthermore, USP5 expression correlated with cancer-associated fibroblasts (CAFs), endothelial cells (EC) and genetic markers of immunodulators in cancers. Moreover, the result from single cell sequencing showed that USP5 could regulate several tumor biological behaviors such as apoptosis, DNA damage and metastasis. Gene enrichment analysis indicated “spliceosome” and “RNA splicing” may be the critical mechanism for USP5 to involve in cancer.
Conclusion
Taken together, our study elucidates the biological significance of USP5 in the diagnosis, prognosis and immune in human pan-cancer.
Transanal formation of anastomosis using C-REX device is safe and effective in high anterior resection
Authors: Vilhjalmsson Dadi , Lepsenyi Mattias , Syk Ingvar , Grönberg Anders , Thorlacius Henrik 
Published: February 2023

Abstract
Purpose
C-REX is a novel instrument for creating stapleless colorectal anastomosis by compression. The aim of this study was to evaluate the safety and effectiveness of C-REX in open- and laparoscopic high anterior resections.
Methods
A prospective clinical study on 21 patients reconstructed with C-REX colorectal anastomosis following high anterior resection of the sigmoid colon using intraabdominal (n = 6) or transanal (n = 15) C-REX instruments for placement of the anastomotic rings. Any signs of complication were prospectively monitored by a predefined protocol. Anastomotic Contact Pressure (ACP) was measured via a catheter-based system and time for evacuation of the anastomotic rings by the natural route was noted. Blood samples were collected daily and flexible sigmoidoscopy was performed postoperatively to examine macroscopic appearance of the anastomoses.
Results
One patient operated with the intraabdominal anastomosis technique with an ACP of 50 mBar had to be reoperated because of anastomotic leakage. None of the 15 patients operated with the transanal technique had anastomotic complications and their ACP ranged between 145–300 mBar. C-REX rings were uneventfully expelled by the natural route in all patients after a median of 10 days. Flexible sigmoidoscopy showed well-healed anastomoses without stenosis in 17 patients and a moderate subclinical stricture in one patient.
Conclusion
These results indicate that the novel transanal C-REX device is a safe and effective method for colorectal anastomosis following high anterior resections, irrespective of open or laparoscopic approach. Moreover, C-REX allows measurement of intraoperative ACP and thereby a quantitative evaluation of the anastomotic integrity.
A new self-adaptive iterative method for variational inclusion problems on Hadamard manifolds with applications
Authors: Sahu D. R. , Babu Feeroz , Sharma Shikher 
Published: February 2023

Abstract
The objective of this work is to design a new iterative method based on Armijo's type-modified extragradient method for solving the inclusion problem (A+B)-1 (0), where A is a maximal monotone vector field and B is a continuous monotone vector field. The proposed method requires one projection at each iteration, reducing the cost of computational viewpoint and improving the rate of convergence. A convergence theorem is established for the proposed extragradient method, which significantly improves existing results. We provide concrete examples of Hadamard manifolds and convergency for numerical confirmation. Moreover, we demonstrate convergence results for the variational inequality problems in which the vector field's monotonicity can be removed.
Parent supervision lightweight solution against version number attacks for IoT networks
Authors: Rouissat Mehdi , BELKHEIR Mohammed , Mokaddem Allel 
Published: February 2023

Abstract
With the rapid involvment of IoT networks in almost all aspects of our daily life, the security concern is being more challenging to protect the enormous amount of the data exchanged over theses networks. Statisitcs reveal that threats against IoT networks are more and more growing , while DoS attacks are taking the lead. However, mitigation solutions against attacks targetting IoT networks must be developped while taking into consideration the network scalability, but also they should fit with the limited resources of IoT devices in terms of processing, storage, energy efficiency, and connectivity-loss. For thi aim, the present work proposes a lightweight detection and mitigation solution against the version number attack "VNA" which is considered as one among the haitful DoS attacks against IoT networks. The proposed decentralized algorithm targets the edge part of the netowrk. Upon an illigitimate incremented version number the sink node is informed via an alert DAO message by the malicious node parent, and it disseminates this information through the overall network to advertise the malicois originator. Beside its efficiency, the proposed algorithm does not involve any encryption algorithm, it does not generale any heavyweight computation, nor a specific extra node is needed for monitoring the network. Simulations were carried out to demonstrate the effectiveness of the solution in terms of control overhead, energy efficiency, latency, and memory footrpint.
Global real-life analysis of survival and usage of therapies in multiple myeloma
Authors: Lopez-Muñoz Nieves , Hernández Gema , Alonso Rafael , Pina Jose Maria Sánchez , Ayala Rosa , Calbacho Maria , Cuellar Clara , Cedena Maria Teresa , Jimenez Ana , Iñiguez Rodrigo , Pedrera Miguel , Rojo Jaime Cruz , Meloni Laura , Pérez-Rey David , Serrano Pablo , Cruz Javier De la , Martinez-Lopez Joaquín 
Published: February 2023

Abstract
Background: Survival in multiple myeloma has improved significantly in recent years, especially in young patients. This is due to the introduction of new drugs with new mechanisms of action. We reviewed the evolution of the survival of patients with MM between 1999 and 2020 at our 12 de Octubre Hospitalinstitution. Then, to confirm our results, we used data from TriNetx, a global health research platform that includes patients from Europe and US.
Methods: Using the H120 cohort, with 703 patients, we compared survival time since MM diagnosis in three groups based on age at MM diagnosis over three time periods. Comparator cohorts included 62,572 patients from US Collaborative Network and 6,377 patients from EMEA Collaborative Network. Finally, we analysed differences in the patterns of treatment between networks across the world. Kaplan‒Meier analysis was used to estimate survival probabilities,and between-group differences were tested using the log-rank test and hazard ratio.
Results: For patients from H12O, the median OS was 35.61 (28.38-42.84, 95% CI), 55.59 (40.20-70.98, 95%) and 68.67 (54.92-82.42, 95%) months for the 1999-2009, 2010-2014 and 2015-2020 cohorts, respectively (p=0.0001). Among all patients included in the EMEA network, the median OS was 20.32 months vs. 34.75 months from 1999-2009 vs. 2010-2014. The median OS from the 2010-2014 vs. 2015-2020 time cohorts was 34.75 months vs. 54.43 months, respectively. In relation to the US cohort, the median OS from before 2010 vs. 2010-2014 wasnot reached in either time cohort and neither when comparing the 2010-2014 vs. 2015-2019 time cohorts. Bortezomib is the most commonly used drug in the EMEA cohort, while lenalidomide is the most commonly used drug in the US cohort.
Conclusions: This large-scale study based on real-world data confirms the previous finding that MM patients have increased their survival in the last two decades.
Multivariate models for the prediction of febrile seizure risk and recurrence: a prospective case-control study
Authors: Papež Jan , Labounek René , Jabandžiev Petr , Česká Katarína , Slabá Kateřina , Ošlejšková Hana , Aulická Štefania , Nestrasil Igor 
Published: February 2023

Abstract
Our goal was to identify highly accurate empirical models for the prediction of the risk of febrile seizure (FS) and FS recurrence. In a prospective, three-arm, case-control study, we enrolled 162 children (age 25.8±17.1 months old, 71 females). Participants formed one case group (patients with FS) and two control groups (febrile patients without seizures and healthy controls). The impact of blood iron status, peak body temperature, and participants’ demographics on FS risk and recurrence was investigated with univariate and multivariate statistics. Serum iron concentration, iron saturation, and unsaturated iron-binding capacity differed between the three investigated groups (pFWE<0.05). These serum analytes were key variables in the design of novel multivariate linear mixture models. The models classified FS risk with higher accuracy than univariate approaches. The designed bi-linear classifier achieved a sensitivity/specificity of 83%/89% and was closest to the gold-standard classifier. A multivariate model assessing FS recurrence provided a difference (pFWE<0.05) with a separating sensitivity/specificity of 79%/69%. Iron deficiency, height percentile, and age were significant FS risk factors. In addition, height percentile and hemoglobin concentration were linked to FS recurrence. Novel multivariate models utilizing blood iron status and demographic variables predicted FS risk and recurrence among infants and young children with fever.