bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
Authors: Melnick Ashley F. , McCarter Anna C. , Liang Shannon , Liu Yiran , Wang Qing , Dean Nicole A. , Choe Elizabeth , Kunnath Nicholas , Bodanapu Geethika , Mullin Carea , Akter Fatema , Lin Karena , Magnuson Brian , Kumar Surinder , Lombard David B. , Muntean Andrew G. , Ljungman Mats , Sekiguchi JoAnn , Ryan Russell J.H. , Chiang Mark Y. 
Published: January 2023

AbstractActivated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic in clinical trials. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a Notch cofactor and component of transcriptional machinery, a potential target in T-ALL. While we confirmed previous work that CDC73 interacts with NOTCH1, we also found that the interaction in T-ALL was context-dependent and facilitated by the lymphoid transcription factor ETS1. Using mouse models, we showed that Cdc73 is important for Notch-induced T-cell development and T-ALL maintenance. Mechanistically, Cdc73, Ets1, and Notch intersect chromatin at promoters and enhancers to activate oncogenes and genes that are important for DNA repair and oxidative phosphorylation. Consistently,Cdc73deletion in T-ALL cells induced DNA damage and impaired mitochondrial function. Our data suggests that Cdc73 might promote a gene expression program that was eventually intersected by Notch to mitigate the genotoxic and metabolic stresses of elevated Notch signaling. We also provide mechanistic support for testing inhibitors of DNA repair, oxidative phosphorylation, and transcriptional machinery. Inhibiting pathways like Cdc73 that intersect with Notch at chromatin might constitute a strategy to weaken Notch signals without directly targeting the Notch complex.
Evidence for noisy oscillations of cAMP under nutritional stress condition in budding yeast
Authors: Colombo Sonia , Collini Maddalena , D’alfonso Laura , Chirico Giuseppe , Martegani Enzo 
Published: January 2023

ABSTRACTThe Ras/cAMP/PKA pathway is one of the best studied signalling pathway in the budding yeast that regulates cellular responses to nutrients availability and stress. The cAMP levels and the PKA activity are also subjected to a strong negative feedback that operates either through the activity of the phosphodiesterase Pde1 and also on the amount of Ras2-GTP. We have previously made and simulated a dynamic model of the whole pathway and our results suggest the existence of stable oscillatory states that depend on the activity of the RasGEF (Cdc25) and RasGAP (Ira proteins) (Pescini et al. Biotechnol Adv 30, 99-107, 2012). Stochastic oscillations related to activity of the pathway were reported by looking at the nuclear localization of the trascription factors Msn2 and Msn4 (Gamedia-Torres et al. Curr Biol 17, 1044-9, 2007). In particular Medvedik et al. (PloS Biol 5, 2330-41, 2007) reported stable oscillations of the nuclear accumulation of Msn2 in condition of limited glucose availabiliy.We were able to reproduce the periodic accumulation of Msn2-GFP protein in yeast cells under condition of limiting glucose, and we tried to detect also in the same condition oscillations of cAMP levels in single yeast cells. We used a specific Fluorescence Resonance Energy Transfer (FRET) sensor based on a fusion protein between CFP-EPAC-YFP expressed in yeast cells. The FRET between CFP and YFP is controlled by cAMP concentration. This sensor allows us to monitor changes in cAMP concentrations in single yeast cell for a relative long time and a peak of cAMP was normally detected after addition of glucose to derepressed cells (Colombo et al. Biochem Biophys Res Commun 487, 594-99, 2017). Using this method we were able to detect noisy oscillations of cAMP levels in single yeast cells under condition of nutritional stress caused by limiting glucose availability (0.1%). We used Spectral analysis to discriminate between true oscillations and random noise. The oscillations were characterized by period of about 4-5 min, close to that observed for Msn2-GFP oscillations.
EDA2R/NIK signaling promotes skeletal muscle atrophy linked to cancer cachexia
Authors: Nur Bilgic Sevval , Domaniku Aylin , Toledo Batu , Agca Samet , Weber Bahar Z. C. , Arabaci Dilsad H. , Ozornek Zeynep , Lause Pascale , Thissen Jean-Paul , Loumaye Audrey , Kir Serkan 
Published: January 2023

SummarySkeletal muscle atrophy is a hallmark of the cachexia syndrome that is associated with poor survival and reduced quality of life in cancer patients1. Muscle atrophy involves excessive protein catabolism and loss of muscle mass and strength2. An effective therapy against muscle wasting is lacking as mechanisms driving the atrophy process remain incompletely understood. Our gene expression analysis in muscle tissues revealed upregulation of Ectodysplasin A2 Receptor (EDA2R) in tumor-bearing mice and cachectic cancer patients. Here we show that activation of EDA2R signaling promotes skeletal muscle atrophy. Stimulation of primary myotubes with EDA2R ligand, EDA-A2, triggered pronounced cellular atrophy via inducing the expression of muscle atrophy-related genesAtrogin1andMuRF1. EDA-A2-driven myotube atrophy involved activation of the noncanonical NFκB pathway and depended on NIK kinase activity. While EDA-A2 overexpression induced muscle wasting in mice, the deletion of EDA2R or muscle NIK protected tumor-bearing mice from the loss of muscle mass and function. Tumor-induced Oncostatin M upregulated muscle EDA2R expression and muscle-specific Oncostatin M Receptor (OSMR) knockout mice were resistant to tumor-driven muscle wasting. Our results demonstrate that EDA2R/NIK signaling mediates cancer-associated muscle atrophy in an OSM/OSMR-dependent manner. Thus, therapeutic targeting of these pathways may be beneficial in preventing muscle loss.
Assessment of climate change mitigation readiness in the Kingdom of Bahrain
Authors: Alsabbagh Maha , Alnaser Waheeb Essa 
Published: January 2023

PurposeThis study aims to assess readiness for climate change mitigation in the Kingdom of Bahrain.Design/methodology/approachTwo stages were followed aiming at understanding the situation related to climate change mitigation in Bahrain and assessing the mitigation readiness. Baseline and mitigation scenarios for the period 2019–2040 were developed using the Low Emissions Analysis Platform software based on historical emissions and energy data for the period 1990–2018. Using the analytic hierarchy process, the mitigation readiness was assessed by 13 experts, and priority areas for mitigation action were identified.FindingsCO2e emissions are projected to grow continuously. However, no explicit climate change strategy is in place yet. Mitigation is tackled implicitly through energy efficiency and renewable energy initiatives. These initiatives can make 23% reduction in CO2e emissions by 2040. Adopting additional measures is needed to achieve the recently set emission reduction target of 30% by 2035. The findings revealed potential areas for improving mitigation efforts in Bahrain. Priority areas for mitigation actions, as identified by experts, were mainly related to policy and governance. Focus needs to be paid to the social aspect of climate change mitigation.Originality/valueLiterature on mitigation readiness in developing countries is sparse. Knowledge of the requirements for climate change mitigation and assessment of the country’s performance can prioritize areas for improving mitigation action. Several lessons can be learnt from the case of Bahrain. In addition, the adopted methodology can be applied to other developing or Arab countries at local or institutional levels. However, its application to specific sectors may require adjustments.
Gaining resilience through transformative services in cause-related events: an interaction ritual chain perspective
Authors: Wong IpKin Anthony , Lin Xueying (Linda) , Lin Zhiwei (CJ) , Lin Yuxun (Emily) 
Published: January 2023

Purpose
This study aims to unlock a ritual chain mechanism that promotes socio-mental (or socio-psychological) resilience. This study draws on interaction ritual chains theory and the concept of transformative service to answer the question of how people could be inspired toward an elevated level of group solidarity, emotional energy, morality and, thus, socio-mental resilience.

Design/methodology/approach
This study took a qualitative approach resting upon online reviews and observations from an augmented food festival about hot pot delicacies dedicated to medical workers fighting hard amid the early coronavirus outbreak.

Findings
The results of this study point to four primary ritual outcomes (e.g. emotional energy, group solidarity, symbols of relationships and standards of morality) along with a two-tier micro–macro socio-mental resilience sustainability paradigm.

Research limitations/implications
Empirical findings from this study could help operators to justify their transformative initiatives as means for customers to replenish their depleted physical and mental resources.

Originality/value
This inquiry presents new nuances to interaction ritual chains. This study also extends the transformative role of hospitality services to accentuate a linkage among individuals, communities and the society.
A system dynamic model for Indonesian petrochemical industry emission reduction
Authors: Sylvia Endang , Sunitiyoso Yos 
Published: January 2023

Purpose
This paper aims to identify all variables and parameters related to business and emission within the petrochemical industry. The variables and parameters specified will be modeled into a system dynamic model that will be a baseline for the proposed best scenario(s) to address the business issue related to emission reduction in the petrochemical industry.

Design/methodology/approach
Literature review and stakeholder interviews were conducted to define the key factors contributing to the emission reduction of the petrochemical industry. The key factors are then developed into a system dynamic model to measure the quantitative impact of changes in those variables on emission and industry profitability.

Findings
This paper provides an analysis of system dynamic model. It suggests that process optimization can lead to a slight amount reduction in emissions. In contrast, a significant reduction shows in the simulation result of bio-based feedstock utilization and implementation of advanced technology. To sustain the emission reduction, strong commitment from stakeholders and support from the government will play an important role.

Research limitations/implications
This research is limited to problem analysis of the primary product (high-value chemical) of the petrochemical industry by only considering the changes in the key factors of emission reduction.

Practical implications
This paper includes implications for interventions that can be imposed to reduce emission while retaining the business profitability.

Originality/value
The contribution of this study is to find the best scenario that can boost emission reduction within Indonesia’s petrochemical industry.
Determinants of catastrophic household health expenditure in Nigeria
Authors: Opeloyeru Olaide Sekinat , Lawanson Akanni Olayinka 
Published: January 2023

PurposeThe purpose of this paper is to examine the determinants of catastrophic household health expenditure in Nigeria, with particular focus on Out-of-Pocket (OOP) health expenditure. Payments for healthcare through OOP are the major means of channeling funds to healthcare providers in many developing countries including Nigeria. It has great consequence on household well-being, especially when it is difficult for household to meet up with spending on other necessity goods.Design/methodology/approachThe demand for health theory provided the theoretical framework. The study used data from 2018/2019 Nigeria Living Standard Survey (NLSS) with catastrophic thresholds of 10 and 25%. A logistic regression model was used, while Pearson chi-squared test was used for models' goodness of fit.FindingsBased on the obtained result using Pearson chi-squared, at 10% threshold of total non-food expenditure, the likelihood of experiencing catastrophic health expenditure increased with secondary education, for those without health insurance and for severely ill or injured by 1.48, 2.57 and 8.70, respectively. It fell for those who consulted patent medicine vendors/chemists for illness or injury by 0.63 compared to orthodox practitioners. Enhancement of post-secondary education and widening the coverage of the available social health insurance would minimise the financial burden on many households.Originality/valueThis paper fulfills the need to examine the determinants of catastrophic household health expenditure on two catastrophic thresholds and two forms of household expenditure.
Formal and informal institutions and fair value opinion shopping: an institutional anomie theory perspective
Authors: Cao June 
Published: January 2023

PurposeThe objective of this study is to examine how formal and informal institutional environment influences managers’ fair value opinion shopping behaviour in the largest International Financial Reporting Standards adopter, China.Design/methodology/approachTo test the hypotheses, I conduct a 2 × 2 between-subject randomised experiment since the inferences about cause and effect are important in this study. The between-subject experimental situations are manipulated on the basis of the financial condition of companies and boards’ oversight.FindingsI find that managers are likely to seek favourable fair value opinions from external valuation professionals when they are under the weak boards’ oversight and high stress to meet the regulation target of the China Securities Regulatory Commission. These results are more pronounced for managers with higher both rent-seeking and favour-seeking guanxi orientations are more likely to engage in fair value opinion shopping.Originality/valueConsistent with theoretical analysis of Balfoort et al. (2017), this study provides empirical evidence that guanxi influences the neutrality and faithful representation in fair value measurement in China. In addition, the findings extend Salzsieder’s study (2015) and reflect the context-embeddedness nature of accounting.
How do impact investors evaluate an investee social enterprise? A framework of impact investing process
Authors: Agrawal Anirudh , Jespersen Kristjan 
Published: January 2023

Purpose
Impact investors differ from venture capital firms as they invest to create social and commercial value. This paper pursues the question: how do impact investors select social enterprises? The aim of this study is to understand the selection and investing process of impact investors.

Design/methodology/approach
This study developed a database of 115 impact-investing firms across different geographies. Emails were sent to investors associated with each of the impact-investing firms found in the database, out of which 32 replied with consent for a telephonic or in-person interview.

Findings
The significant findings presented in the paper are the following. First, this study shows the impact-investing selection process model. The four major steps in the selection process are context, investment focus, venture analysis and decision. In each step, social values and missions become the defining characteristics of the selection process. Second, the findings also discuss the typologies of impact investors as a function of their selection approaches.

Practical implications
This paper discusses the impact investing strategy among social enterprises. It provides a framework for impact investing among investee social enterprises. As an impact investing professional, one learns investment strategy through this paper.

Social implications
Impact investing is a growing field. It is believed that impact investing could greatly impact sustainable development goals, climate change goals and help in inclusive development. This study helps to further understand impact investing process and hopes to help social enterprises and impact investors make a better match, thereby, creating a greater overall social and environmental impact.

Originality/value
This study helps both practitioners and academics to understand the complexity of impact investing. This study helps develop heuristics that impact investors may use to make investments. This study provides a framework for investing, which the impact investing firms may use to invest.
The role of a local network in achieving contextual ambidexterity in foreign subsidiaries operating in Brazil – a multi-level analysis
Authors: Barcelos Eduardo Jorge Branco Vieira , Borini Felipe Mendes , Amatucci Marcos 
Published: January 2023

Purpose
This study aims to examine how knowledge acquired from a network built on trust and commitment can increase the management team’s effectiveness (MTE) in implementing an ambidextrous subsidiary.

Design/methodology/approach
An online survey was conducted with top managers of foreign subsidiaries operating in Brazil. A total of 289 valid respondents were statistically evaluated using the partial least squares-structural equation modeling technique to test the model and hypotheses. A multilevel analysis research methodology was applied because the conceptual model relates constructs at the micro (political behavior and management team effectiveness) and macro (improved external ties [IET] and contextual ambidexterity [CA]) levels.

Findings
Subsidiaries need to improve the MTE to achieve CA. The authors found that the local network built on trust and commitment facilitates access to differentiated knowledge. Unique knowledge reduces conflicts amongst team members and enhances explorative and exploitative activities to reach CA.

Practical implications
The authors suggest that top managers can increase decision-making effectiveness by using trust and commitment to building a robust local network with selected stakeholders. Privileged knowledge allows attaining constructive political behavior (PB) and leverages exploitative and explorative activities.

Originality/value
The novelty resides in three aspects. First refers to linking CA and foreign subsidiaries in Brazil. Second, suggesting that IET has a double effect, as a moderator between PB and MTE, and concurrently has a direct effect on CA. Third, suggesting that capturing valuable resources from a local network built on the pillars of trust and commitment. Fourth, the authors examine the influence of differentiated knowledge on MTE.
Review of effects of COVID-19 pandemic on the textile industry: challenges, material innovation and performance
Authors: Seidu Raphael Kanyire , Jiang Shou-xiang , Tawiah Benjamin , Acquaye Richard , Howard Ebenezer Kofi 
Published: January 2023

Purpose
The purpose of this study is to present a systematic review of the effects of COVID-19 on the conventional textile production subsector. The emergence of the COVID-19 virus in 2019 has subsequently caused many problems, such as unemployment, business closures, economic instability and high volatility in the global capital markets amongst others within the wider manufacturing industry including textile production.

Design/methodology/approach
Relevant secondary data are obtained from the Scopus database and Statista. Based on the data analysis of 21 seed articles, three research themes are identified: challenges in the textile industry, new material innovations or solutions and the textile industry performance.

Findings
The results reveal that the COVID-19 pandemic has affected the textile industry, disrupted the supply chains of this industry, affected profit margins, stopped employment and impacted the retail of products to customers. Aside from the negative repercussions, there are also good sides to the pandemic which, for instance, range from advanced material innovations to textiles with anti-microbial, self-cleaning and anti-bacterial properties that would limit the transfer of the virus.

Practical implications
Findings reinforced the need for effective strategies and investments in the research and development departments of the various firms in the textile industry to innovate operations and novel materials for the next global pandemic.

Originality/value
Many companies have adopted novel strategies and practices that are helping them to survive the pandemic. This study, therefore, recommends further investigation into material innovations and reimagining strategies by companies and the supply chain within the textile industry so that it is protected against future crises.
Highlight risk management in supply chain finance: effects of supply chain risk management capabilities on financing performance of small-medium enterprises
Authors: Qiao Ruilei , Zhao Lindu 
Published: January 2023

Purpose
The purpose of this paper is to explore the important role of supply chain risk management (SCRM) capabilities as pre-factors for SMEs to improve supply chain financing performance (SCFP), also incorporating the effect of supply chain integration (SCI).

Design/methodology/approach
From the intersection of SCRM and SCF literature, this paper proposed hypothesis to discuss the impact of SCRM capabilities on SCFP and the role of SCI, aiming at combine SCRM with supply chain financing management. The research model was validated applying structural equation modeling on survey data from 286 Chinese small and medium-sized enterprises (SMEs).

Findings
Four dimensions of SCRM capabilities have significant positive effects on SCFP with different significant levels, confirming that they are important pre-factors in supply chain finance (SCF). In addition, the impact of SCRM capabilities on SCFP differ when SCI varies, indicating the promoting effect of SCI.

Practical implications
SMEs should establish SCRM capabilities as supply chain risks greatly influence the evaluation of financial providers and the achievement of SCF. Meanwhile, SCI should be attached for it enables superior SCFP even if SCRM capabilities are relatively limited.

Originality/value
This study represents a pioneering attempt to analyze the pre-factors of SMEs in improving SCFP by combing SCRM with SCF management. Few prior studies have highlighted the importance of SCRM in SCF.
Kiva: wow, $10 million!
Authors: Anderson Joe S. , Williams Susan K. 
Published: January 2023

Research methodology
This compact case is based on secondary, published information about the Kiva organization, both in book and article format, listed in the reference list at the end of this teaching note. In addition, the authors accessed the Kiva website using the Internet Archive Wayback Machine. This allowed to view Kiva’s webpages when they were a startup organization.

Case overview/synopsis
Kiva’s co-founder, Jessica Jackley, is offered $10m by the corporate social responsibility director of a large technology firm. Students discuss why Jessica hesitates to accept the $10m and explore the meaningful application of a nonprofit’s mission statement and the concepts of mission creep and mission drift. The case can be read in class for immediate discussion or assigned outside of class. Ultimately, the students decide and defend whether Jessica should accept the $10m on behalf of Kiva. In the strategic management sections, students were split 35% accept and 65% do not accept which produced a rich discussion.

Complexity academic level
This compact case has been used in several sections of the capstone strategic management course composed of senior, undergraduate and business majors. This case is used early in the course as an application of the mission and values chapter. This case could also be used in management courses in entrepreneurship, nonprofit organizations and principles.