bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connecting the dots? Entrepreneurial ecosystems and sustainable entrepreneurship as pathways to sustainability
Authors: Chaudhary Sanjay , Kaur Puneet , Alofaysan Hind , Halberstadt Jantje , Dhir Amandeep 
Published: June 2023

AbstractWhile the exponential growth of entrepreneurial ecosystem research has dramatically increased our understanding of the role of context in entrepreneurial outcomes, our knowledge of entrepreneurial ecosystems and environmentally sustainable entrepreneurship is still fragmented. There is ambiguity on how entrepreneurial ecosystems influence sustainable entrepreneurship and what factors facilitate or constrain sustainable entrepreneurship. We attempt to take stock of the extant scholarship on entrepreneurial ecosystems and synthesize studies examining their linkages with sustainability. We systematically reviewed 77 articles identified in the World of Science and Scopus databases to discuss the main themes. The content analysis uncovered four key themes: (a) how entrepreneurial ecosystems become more sustainable, (b) the role of entrepreneurs, (c) the role of universities, and (d) the outcomes of sustainable ecosystems. The findings reveal that interactions between different actors, including customers, suppliers, institutions, governments, and universities, can result in a sustainable entrepreneurial ecosystem. The novelty of our study arises from integrating extant studies on entrepreneurial ecosystem and sustainability in a systematic and replicable manner. We observed heightened attention to the environmental challenges in ecosystem literature and entrepreneurs' expanded roles in generating ecological and social value. Future studies can further evaluate the effectiveness of entrepreneurial ecosystems to examine whether creating an entrepreneurial ecosystem has a similar value while achieving sustainable development goals across varied contexts.
ROS‐Mediated Antitumor Activity, Apoptosis, and Molecular Docking Studies of Platinum(II) Coordination Complexes Bearing 2‐(Diphenylphosphino)pyridine Ligands
Authors: Mojaddami Ayyub , Abedanzadeh Sedigheh , Bagherzadeh Mehrafarin , Foroutan Gisou , Khodayar Mohammad Javad , Panahimehr Mohammad , Fereidoonnezhad Masood 
Published: June 2023

AbstractPlatinum‐based drugs have been widely used in cancer treatment. However, their severe side effects have limited their use. So, researchers have been striving to find compounds with fewer side effects and greater efficacy, to overcome these drawbacks. Here, the cytotoxicity of platinum(II) complexes containing 2‐(diphenylphosphino)pyridine ligands have been studied on human lung (A549), ovarian (SKOV3), breast (MCF‐7) cancer, and normal breast (MCF‐10A) cell lines. The most potent compound exhibits a marked cell growth‐inhibitory effect against ovarian and lung cancer cells with IC50 values of 9.41 and 5.58 μM, respectively, which were significantly better than that observed for cisplatin (19.02, and 8.64 μM). Additionally, all complexes achieved significantly lower cytotoxicity towards MCF‐10A. To investigate the interaction of complexes with DNA, an electrophoresis mobility shift assay was conducted, which indicated that complexes bind to DNA and affect its electrophoretic mobility. An analysis of apoptosis in A549 cells supported the conclusion that they inhibits cell proliferation via induction of apoptosis in a concentration‐dependent manner. Molecular docking was also used to investigate the interactions of compounds with different DNA structures. These compounds have the ability to be a suitable pharmaceutical compound with further investigations in the field of cancer research.
Promoting Amination of Furfural to Furfurylamine by Metal‐Support Interactions on Pd/MoO3−x Catalysts
Authors: Wang Zhiyuan , Zheng Yinjian , Feng Jiye , Zhang Wenbiao , Gao Qingsheng 
Published: June 2023

AbstractThe reductive amination of carbonyl compounds is one of the most straightforward protocols to construct C−N bonds, but highly desires active and selective catalysts. Herein, Pd/MoO3−x catalysts are proposed for furfural amination, in which the interactions between Pd nanoparticles and MoO3−x supports can be easily ameliorated by varying the preparation temperature toward efficient catalytic turnover. Thanks to the synergistic cooperation of MoV‐rich MoO3−x and highly dispersed Pd, the optimal catalysts afford the high yield of furfurylamine (84 %) at 80 °C. Thereinto, MoV species not only acts as the acidic promoter to facilitate the activation of carbonyl groups, but also interacts with Pd nanoparticles to promote the subsequent hydrogenolysis of Schiff base N‐furfurylidenefurfurylamine and its germinal diamine. The good efficiency of Pd/MoO3−x within a broad substrate scope further highlights the key contribution of metal‐support interactions to the refinery of biomass feedstocks.
Mixing rules for high density polyethylene‐polypropylene blends
Authors: Stewart Katherine M. E. , Stonecipher Ethan , Ning Haibin , Pillay Selvum Brian 
Published: June 2023

AbstractHigh‐density polyethylene (HDPE) and polypropylene (PP) blends of varying composition have been evaluated in an effort to establish a mixing rule for melt flow index (MFI). In addition, a previously established relationship between MFI and for linear polymers was also evaluated for these blends. It was found that a parabolic relationship existed between the composition (by weight fraction) and MFI and that the MFI and relationship held for this set of polymeric materials. Additionally, all properties and relationships were evaluated over five extrusion cycles, which showed minimal to no deviations over the five cycles.
Theoretical Study on B‐doped FeN4 Catalyst for Potential‐Dependent Oxygen Reduction Reaction
Authors: Wang Ziwei , Qin Yanyang , Wu Tiantian , Zhang Jianrui , Ding Shujiang , Su Yaqiong 
Published: June 2023

AbstractElectrochemical reactions mostly take place at a constant potential, but traditional DFT calculations operate at a neutral charge state. In order to really model experimental conditions, we developed a fixed‐potential simulation framework via the iterated optimization and self‐consistence of the required Fermi level. The B‐doped graphene‐based FeN4 sites for oxygen reduction reaction were chosen as the model to evaluate the accuracy of the fixed‐potential simulation. The results demonstrate that *OH hydrogenation gets facile while O2 adsorption or hydrogenation becomes thermodynamically unfavorable due to the lower d‐band center of Fe atoms in the constant potential state than the neutral charge state. The onset potential of ORR over B‐doped FeN4 by performing potential‐dependent simulations agree well with experimental findings. This work indicates that the fixed‐potential simulation can provide a reasonable and accurate description on electrochemical reactions.
Intra‐ and interspecific variation in spectral properties of dominant Sphagnum moss species in boreal peatlands
Authors: Salko Sini‐Selina , Juola Jussi , Burdun Iuliia , Vasander Harri , Rautiainen Miina 
Published: June 2023

AbstractBoreal peatlands store ~25 % of global soil organic carbon and host many endangered species; however, they face degradation due to climate change and anthropogenic drainage. In boreal peatlands, vegetation indicates ecohydrological conditions of the ecosystem. Applying remote sensing would enable spatially and temporally continuous monitoring of peatland vegetation. New multi‐ and hyperspectral satellite data offer promising approaches for understanding the spectral properties of peatland vegetation at high temporal and spectral resolutions. However, using spectral satellite data to their fullest potential requires detailed spectral analyses of dominant species in peatlands. A dominant feature of peatland vegetation is the genus Sphagnum mosses. We investigated how the reflectance spectra of common boreal Sphagnum mosses, collected from waterlogged natural conditions after snowmelt, change when the mosses are desiccated. We conducted a laboratory experiment where the reflectance spectra (350–2500 nm) and the mass of 90 moss samples (representing nine species) were measured repetitively. Furthermore, we examined (i) their inter‐ and intraspecific spectral differences and (ii) whether the species or their respective habitats could be identified based on their spectral signatures in varying states of drying. Our findings show that the most informative spectral regions to retrieve information about the Sphagnum species and their state of desiccation are in the shortwave infrared region. Furthermore, the visible and near‐infrared spectral regions contain less information on species and moisture content. Our results also indicate that hyperspectral data can, to a limited extent, be used to separate mosses belonging to meso‐ and ombrotrophic habitats. Overall, this study demonstrates the importance of including data especially from the shortwave infrared region (1100–2500 nm) in remote sensing applications of boreal peatlands. The spectral library of Sphagnum mosses collected in this study is available as open data and can be used to develop new methods for remote monitoring of boreal peatlands.
Biocompatible scaffolds based on collagen and oxidized dextran for endothelial cell survival and function in tissue engineering
Authors: Sarvestani Fatemeh Sabet , Tamaddon Ali‐Mohammad , Yaghoobi Ramin , Geramizadeh Bita , Azarpira Negar 
Published: June 2023

AbstractAngiogenesis is a vital step in tissue regeneration. Hence, the current study aimed to prepare oxidized dextran (Odex)/collagen (Col)‐hydrogels with laminin (LMN), as an angiogenic extracellular matrix (ECM) component, for promoting human umbilical vein endothelial cell (HUVEC) proliferation and function. Odex/Col scaffolds were constructed at various concentrations and temperatures. Using oscillatory rheometry, scanning electron microscopy (SEM), and cell viability testing, the scaffolds were characterized, and then HUVEC proliferation and function was compared with or without LMN. The gelation time could be modified by altering the Odex/Col mass ratio as well as the temperature. SEM showed that Odex/Col hydrogels had a more regular three‐dimensional (3D) porous structure than the Col hydrogels. Moreover, HUVECs grew faster in the Col scaffold (12 mg/mL), whereas the Odex (30 mg/mL)/Col (6 mg/mL) scaffold exhibited the lowest apoptosis index. Furthermore, the expression level of vascular endothelial growth factor (VEGF) mRNA in the group without LMN was higher than that with LMN, and the Odex (30 mg/mL)/Col (6 mg/mL) scaffold without LMN had the highest VEGF protein secretion, allowing the cells to survive and function effectively. Odex/Col scaffolds, with or without LMN, are proposed as a tissue engineering construct to improve HUVEC survival and function for angiogenesis.
Association between adeno‐associated virus genomic titers and intracellular plasmid levels
Authors: Masumi‐Koizumi Kyoko , Yuan Yuzhe , Higashiyama Kiyoko , Yusa Keisuke , Uchida Kazuhisa 
Published: June 2023

AbstractThe recombinant adeno‐associated viral (rAAV) vector is one of the most effective viral vectors in gene therapy because of its low immunogenicity, high transduction efficiency, broad tissue specificity, and long‐term transgene expression ability. HEK293T cells are widely used to produce rAAV vectors, and acquisition of high rAAV‐producing cells is one of the essential processes for higher rAAV vector production. To acquire such cells, a method to identify cells with high expression of transgene protein was developed; however, the relationship between high expression of transgene protein and increased production of rAAV has not been sufficiently studied to date. We used the fluorescent protein ZsGreen1 as a transgene, subdivided the adherent cells according to the intensity of transgene expression protein, and reconfirmed the relationship between rAAV vector production and the amount of intracellular plasmid. We found that the amount of rAAV produced was not correlated with the intensity of expression of the transgene protein but may be correlated with the amount of intracellular plasmid. We also found that cells with high expression of transgene protein might not necessarily produce large amounts of rAAV vector. Based on these results, it was suggested that intracellular plasmid copy number could be used as a new marker for cells producing high levels of rAAV vector.
A population level analysis of second hematological malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma survivors in the era of targeted therapies
Authors: Mishra Rahul , Dima Danai , Kumar Sumukh A. , Mian Agrima , Taneja Alankrita , Karna Rahul , Caimi Paolo F. , Hill Brian T. , Dean Robert , Jagadeesh Deepa 
Published: June 2023

AbstractWith improvement in survival after chronic lymphocytic leukemia (CLL) diagnosis, the real‐world burden of second hematological malignancies (SHM) has not been comprehensively assessed in recent era. We analyzed risk, incidence, and outcomes of SHM in CLL patients between 2000 and 2019 using SEER database. CLL patients had greater risk for hematological malignancies than general population [SIR, standardized incidence ratio (95% CI):2.58 (2.46–2.70); p < 0.05]. The risk for subsequent lymphoma increased by 1.75 folds in 2015–2019 compared to 2000–2004. The duration, after CLL diagnosis, of maximum risk for SHM decreased as 60–119 months for time‐period 2000–2004, 6–11 months for 2005–2009 to 2–5 months for 2010–2014 and 2015–2019. Incidence of SHM was 2.5% in CLL survivors (1736/70,346) with lymphoid SHM being more common than myeloid SHM, and DLBCL being the most common pathology (n = 610, 35% of all SHM). Male sex, age ≤65 years at CLL diagnosis, and chemotherapy treatment were associated with higher risk for SHM. The median gap between CLL and SHM diagnoses was 46 months. The median survival for de‐novo‐AML, t‐MN, CML, and aggressive NHL was 63, 86, 95, and 96 months respectively. Although SHM remains rare, there is increased risk in recent era, likely due to improved survival in CLL patients, necessitating active surveillance strategies.
Emulation of auditory senses depending on chaotic dynamics of threshold switching memristor
Authors: Yu Junwei , Zeng Fei , Wan Qin , Lu Ziao , Pan Feng 
Published: June 2023

AbstractEmulating the auditory sense is a significant challenge in terms of both integration and energy consumption for handling complicated spatiotemporal information. Here, we demonstrate how to utilize the chaotic dynamics of a threshold switching memristor, which usually acts as a leaky integrate and fire neuron in the neuromorphic network, to encode the frequency and amplitude in auditory information. We fabricate a Pd/Nb/NbOx/Nb/Pd memristor dominated by the Poole–Frankel conduction mechanism, set its state at the edge of chaos, and stimulate it using periodic perturbations. The memristor's responses to the perturbation frequencies can be categorized into three zones. Two are phase locking with linear phase–frequency relationships, and one has a hyperbolic spike number–frequency relationship. The memristor system also enables intensity coding and tonotopy by modulating the response spikes in either the locked phase or spike number. Based on the emulation of these two features, the memristor system demonstrates sound location and frequency mixing. Our study suggests a novel routine for handling the auditory and visual senses using threshold‐switching memristor arrays to enhance the efficiency of neuromorphic networks.image
Favorable recovery profiles and good reliability among youngest unrelated stem cell donors supports lowering the minimum donor registration age
Authors: Ros‐Soto Jose , Pryce Angharad , Zoubek Eva , Burlton Catherine , Szydlo Richard , Anthias Chloe 
Published: June 2023

AbstractIntroductionYounger donor age in hematopoietic cell transplantation has been associated with improved overall and disease‐free survival. Safety data on peripheral blood stem cell (PBSC) and bone marrow (BM) donation is well established, including in the <18‐year old age group in the related setting. In response, Anthony Nolan became the first stem cell donor registry to lower the minimum age for unrelated donors to 16‐years.Materials and MethodsThis retrospective study reviewed unrelated donors donating PBSC or BM for the first time between April 2015 and October 2017 since adoption of the lowered recruitment age. Data were collected from registry electronic database and structured follow‐up questionnaires. Primary outcomes were turnaround time from VT to donation, optimal cell yield achievement, and physical and emotional recovery.ResultsOut of a total of 1013 donors, there were no differences between the different age groups in proportion of donors achieving optimal CD34+ or TNC (PBSC and BM, respectively). There was no increased central line requirement for younger donors or increased emergency telephone support.Youngest donors were more likely to report physical recovery 2 and 7 days post‐PBSC (P = .024 and P = .015, respectively) as well as an earlier emotional recovery (P = .001) and fewer physical symptoms 1 week BM donation (P = .04).ConclusionThis study shows that younger donors are as reliable as older donors, and have favorable recovery profiles without need for increased support at any stage of the donation, supporting Anthony Nolan recruitment strategy and offering reassurance to donor registries considering the same.
Professionals' perspectives on relevant approaches to psychological care in moral injury: A qualitative study
Authors: Serfioti Danai , Murphy Dominic , Greenberg Neil , Williamson Victoria 
Published: June 2023

AbstractObjectives: Despite the increasing consensus that moral injury (MI) is a unique type of psychological stressor, there is an ongoing debate about best practices for psychological care. This qualitative study explored the perceptions of UK and US professionals in the field of MI investigating advances and challenges in treatment or support delivery and issues relating to treatment/support feasibility and acceptability. Methods: 15 professionals were recruited. Semi‐structured, telephone/online interviews were carried out, and transcripts were analyzed using thematic analysis. Results: Two interconnected themes emerged: perceived barriers to appropriate care for MI cases and recommendations for providing effective care to MI patients. Professionals highlighted the challenges that occur due to the lack of empirical experience with MI, the negligence of patients' unique individual needs and the inflexibility in existing manualised treatments. Conclusions: These findings illustrate the need to evaluate the effectiveness of current approaches and explore alternative pathways, which will effectively support MI patients in the long‐term. Key recommendations include the use of therapeutic techniques which lead to a personalised and flexible support plan to meet patients' needs, increase self‐compassion and encourage patients to reconnect with their social networks. Interdisciplinary collaborations (e.g., religious/spiritual figures), could be a valuable addition following patients' agreement.
Enhanced carbon dioxide membrane‐based absorption with amino acid solutions
Authors: Sefidi Vida Sang , Winand Inés , Luis Patricia 
Published: June 2023

AbstractBackgroundCurrent technologies for carbon dioxide (CO2) capture are based on a variety of physical and chemical processes using absorption towers. Overcoming the high energy consumption of conventional absorption is essential to develop a process that makes sense in terms of CO2 captured versus CO2 emitted. In this work, we propose the use of a membrane contactor that allows an efficient gas–liquid contact and an aqueous alkaline solution with several amino acids (i.e. arginine, methionine, valine, serine, 6‐aminohexanoic acid) as the absorption liquid.ResultsResults show clear differences in absorption performance among the studied amino acids, with arginine as the best choice. Using arginine does not only lead to the highest mass transfer coefficient (ca 0.004 m3 m−2 min−1) in the membrane contactor but also a remarkable CO2 absorption capacity without the need for an alkaline component that enhances the reaction and the mass transfer.ConclusionThe use of membrane contactors with a green solvent is a promising step that needs further studies. As the results demonstrate, arginine has shown a great performance; thus, it has been chosen for further investigation. © 2023 Society of Chemical Industry.
Mothers' symptoms of anxiety and depression and the development of child temperament: A genetically informative, longitudinal investigation
Authors: Ahmadzadeh Y. I. , Eilertsen E. M. , Cheesman R. , Rayner C. , Ystrom E. , Hannigan L. J. , McAdams T. A. 
Published: June 2023

AbstractBackgroundChild temperament traits and mothers' emotional symptoms relating to anxiety and depression may drive changes in one another, leading to their ‘co‐development’ across time. Alternatively, links between mother and child traits may be attributable to shared genetic propensities. We explored longitudinal associations between mothers' emotional symptoms and child temperament traits and adjusted for genetic effects shared across generations.MethodsThis study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa). Mothers (n = 34,060) reported on their symptoms of anxiety and depression, and temperament among offspring (n = 42,526), at child ages 1.5, 3 and 5 years. Structural equation models parameterised developmental change in traits, and an extended family design adjusted for genetic effects.ResultsWe found individual differences in stable trait scores and rate of change for all study variables. Longitudinal stability in mothers' emotional symptoms was associated with longitudinal stability in offspring emotionality (r = 0.143), shyness (r = 0.031), and sociability (r = −0.015). Longitudinal change in mothers' symptoms showed very small or negligible correlations with longitudinal change in child temperament. Both genetic and environmental influences explained the stable longitudinal association between mothers' symptoms and child emotionality.ConclusionsThe studied associations between mother and child traits across time appeared to be due to stable, trait‐like factors, involving genetic and environmental influence, rather than their co‐development. Findings contribute knowledge on how emotional symptoms develop in families across time, and the methods with which we can explore such development.