bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Computed Tomography Angiography to Prevent Vascular Injuries in 4-Part Proximal Humerus Fracture-Dislocations
Authors: Ferrera Fernando , Lawrence Dylan , Williams D. Patrick 
Published: May 2023

Cases:
This study compares 2 cases of 4-part proximal humerus fracture-dislocations managed by reverse total shoulder arthroplasty: one with significant medialization and acute surgical management and another with mild medialization and delayed surgical management. Both presented with normal vascular examination; however, computed tomography angiography (CTA) revealed vascular involvement necessitating thoracic or vascular surgery consultation.

Conclusion:
Although vascular injuries are rare, they should be considered in patients with complex injuries, particularly those with delayed treatment or medialization of a bony structure. Our cases highlight important fracture characteristics where a preoperative CTA should be considered even with a normal vascular examination.
The Effect of Return on Equity, Earnings Per Share, and Price Earning Ratio on Stock Prices
Authors: Fakhroni Imam , Futaqi Faruq Ahmad 
Published: May 2023

This study aims to analyze the effect of return on equity (ROE), earnings per share (EPS), and price earning ratio (PER) partially and jointly (simultaneously) on the share prices of processed food sub-industry companies listed on ISSI during the period 2016 – 2020. This study had test samples of 7 processed food sub-industry companies listed on the Indonesia Sharia Stock Index (ISSI). The data used in the study was panel data type with 35 samples while the type of research used was associative research with a quantitative approach and using panel data regression. The results of the t-statistics test show that the ROE and PER variables have a negative and insignificant influence on stock prices. The EPS variable has the results of t-statistics testing, which has a positive and significant effect on stock prices. Based on the results of the F-statistic test, the variationof ROE, EPS, and PER together (simultaneously) has a positive and significant effect on the stock price. The change in stock price in this study can be explained by the ROE, EPS, and PER variables of 27% and the remaining 73% is explained by other variables outside the variables in this study.
IADC Code Upgrade: Data Collection and Workflow Required to Conduct Bit and BHA Forensics to Create Effective Changes in Practices or Design
Authors: Watson William , Dupriest Fred , Witt-Doerring Ysabel , Sugiura Junichi , Pastusek Paul , Daechsel Dustin , Abbas Raafat , Shackleton David , Amish Mohamed 
Published: May 2023

Summary
This paper introduces a forensic workflow that can be used to link drill-bit and bottomhole assembly (BHA) damage to drilling dysfunction. This paper will also discuss the data that should be collected and how it should be processed to enable operational practices and engineering design changes to address these issues.
There is a vast amount of data collected in all drilling operations that can be used to improve performance if utilized within an effective forensic workflow. Several drilling forensic case studies were developed and critically reviewed by subject matter experts from across the industry. From the causal analysis for each case study, an assessment was performed on what information was (1) available, (2) required to diagnose the cause, and (3) not available but would have been preferred. The way the team communicated and acted on the data was also documented.
By combining the learnings from these case studies, it was observed that a guided approach can improve data collection and lead to a more consistent, accurate, timely, and causal analysis with appropriate remedial actions. The process discussed within has been refined to support data collection for forensic analysis and provides a reference for field- and office-based drilling professionals. These practical guidelines have been developed to offer a foundation for a drilling forensic data collection methodology as well as training for the industry—they have been created such that they can grow organically and will form part of the International Association of Drilling Contactors (IADC) Bit Dull Grading Recommended Practice to support the IADC dull grade manual. In the future, these can be used for developing subsequent industry publications.
The work described in this paper is part of a joint IADC/Society of Petroleum Engineers industry effort to revise the IADC dull grade manual.
A catch bond mechanism with looped adhesive tethers for self-strengthening materials
Authors: Dansuk Kerim , Pal Subhadeep , Keten Sinan 
Published: May 2023

AbstractThe lifetime of chemical bonds shortens exponentially with force. Oddly, some protein-ligand complexes called catch bonds exhibit a sharp increase in lifetime when pulled with greater force1. Inventing catch bond interfaces in synthetic materials would enable force-enhanced kinetics or self-strengthening under mechanical stress. We present a molecular design that recapitulates catch bond behavior between nanoparticles tethered with macromolecules, consisting of one looped and one straight tether linking particles with weak adhesion. We calibrate the loop stiffness such that it opens around a target force to enable load-sharing among tethers, which facilitates a sequential to coordinated failure transition that reproduces experimental catch bond force-lifetime curve characteristics. We derive an analytical relation validated by molecular simulations to prove that loop and adhesion interactions can be tailored to achieve an unprecedented spectrum of catch bond lifetime curves with this simple design. Our predictions break new ground towards designing tunable, catch-bond inspired self-strengthening materials.
Token Open Secure and Practical NTRU-based Updatable Encryption
Authors: Song Yang , Gao Haiying , Wang Shiyu , Ma Chao , Sun Keshuo 
Published: May 2023

Abstract

Updatable encryption (UE) is suitable for key rotation and ciphertexts update in the cloud storage environment. A new security model for UE named Token Open security model is presented recently, which is closer to the real attack scenario. And the existing post-quantum secure UE schemes are all based on the LWE assumption without engineering implementation. In this paper, we improve the recently presented security model, which allows the adversary to corrupt all update tokens and keys of the past epochs. We show that our new model reflects the characteristics of UE. Then we construct the first UE scheme based on NTRU, named NTRU-UE. Our new scheme uses the key-switching technique to achieve backward-leak uni-directional key update and uni-directional ciphertext update and uses the ciphertext-masking technique to achieve rand-update. We show that the new scheme is secure under our new model. In addition, we accomplish the software implementation of NTRU-UE and the experiment results show that the scheme meets the practical requirements.
Excess Heat Production of the Pair Annihilation of Ionic Vacancies in a Copper Redox Reaction using a Double Bipolar MHD Electrode
Authors: Miura Makoto , Sugiyama Atsushi , Oshikiri Yoshinobu , Morimoto Ryoichi , Mogi Iwao , Miura Miki , Yamauchi Yusuke , Aogaki Ryoichi 
Published: May 2023

Abstract
By using a copper double bipolar magnetohydrodynamic (MHD) electrode (MHDE) producing twice the amounts of ionic vacancies than a conventional single MHDE, the molar excess heat of the pair annihilation of ionic vacancies, 702 kJ mol-1 at 10 T on average was obtained in a copper redox reaction. It was about twice larger as that of a single MHDE, 387 kJ mol-1 at the same magnetic field. This result strongly suggests that a multi-channel bipolar MHDE will produce much greater excess heat. To conserve the linear momentum and electric charge during electron transfer in an electrode reaction, ionic vacancies are created, storing the solvation energy in the polarized core of the order of 0.1 nm, and the pair annihilation of the vacancies with opposite charges liberates the energy as excess heat. From the promoted excess heat production by the double bipolar MHDE, the reproducibility of the thermal measurement was experimentally validated. At the same time, it was concluded that at magnetic fields beyond 10 T, the concentration of ionic vacancy and the collision efficiency take constant uppermost values.
Efficacy and safety of Wuling capsule combined with antidepressant drugs in the treatment of major depressive disorder: A systematic review with meta-analysis
Authors: Li Wangtao , Guo Liyuan , Hu Yiying , Liu Lanying 
Published: May 2023

Abstract
Background: Major depressive disorder (MDD) is a public health problem covering the world. According to the World Health Organization (WHO), more than 300 million people around the world suffer from MDD, which can cause huge social and economic losses.Medical therapy is the main treatment for MDD. However, antidepressants often have delayed efficacy and many side effects, which seriously affect the quality of life of patients.To systematically evaluate the efficacy and safety of Wuling capsule combined with antidepressant drug in the treatment of patients with MDD.
Methods: Relevant documents published before December 1st, 2022 were retrieved from CNKI, WANFANG DATA, SinoMed, VJIP, CBM, Web of Science, Pubmed, Embase, PsycINFO, ICTRP, and Clinical Tra databases. Randomized controlled trials (RCTs) that meet the inclusion criteria were selected. Their qualities were evaluated and classified. The meta-analysis was performed using RevMan 5.4, and heterogeneity test and publication bias evaluation were performed.
Results: This review includes 1835 patients from 19 RCT studies. The research takes the intervention mode as the variable. The results show that compared with using antidepressant drug alone, using Wuling capsule combined with antidepressant drug displays statistical significance in MDD patients’ Hamilton Depression Scale score (HAMD) [mean difference (MD)=-3.86, 95%CI (-4.05, -3.67), P<0.001], Treatment Emergent Symptom Scale score (TESS) [MD=-2.13, 95%CI (-2.67, -1.58), P<0.001], the effective rate [risk ratio (RR)=1.17, 95%CI (1.12, 1.22), P<0.001], and the incidence of side effects [RR=0.45, 95%CI (0.33, 0.61), P<0.001].
Conclusions: Compared with antidepressants alone, the Wuling capsule has an advantage in improving the HAMD score of patients with MDD, and the side effects are significantly less than those of the control group. Through this study, we believe that the Wuling capsule can be used as a safe and effective adjunctive drug for the treatment of patients with MDD. However, the quality of the evidence still needs to be further improved, and more high-quality clinical trials are needed to increase the credibility of the evidence.
Full-waveform tomography reveals iron spin crossover in Earth’s lower mantle
Authors: Zhuang Jingyi , Lei Wenjie , Wentzcovitch Renata , Trampert Jeannot , Tromp Jeroen , Cobden Laura 
Published: May 2023

Abstract
Joint interpretation of bulk and shear wave speeds constrains the chemistry of the deep mantle. At all depths the diversity of wave speeds cannot be explained by an isochemical mantle. Between 1000 and 2500 km depth, hypothetical mantle models containing an electronic spin crossover in (Mg,Fe)O provide a significantly better fit to the wave-speed distributions, as well as more realistic temperatures and silica contents, than models without a spin crossover. Below 2500 km, wave speed distributions are explained by an enrichment in silica towards the core-mantle boundary. This silica enrichment may represent the fractionated remains of an ancient basal magma ocean.
Comparison of radiological outcomes for moderate and severe hallux valgus following distal chevron osteotomy and modified McBride procedure
Authors: Lin Chung-Wei , Chiang Cheng-Hung , Wang Wei-Chih , Yeh Chen-Wei , Chen Hsien-Te , Fong Yi-Chin , Kuo Chien-Chung 
Published: May 2023

Abstract

Background.Hallux valgus (HV) is a common forefoot disorder with hundreds of proposed management techniques. Distal chevron osteotomy with a modified McBride procedure has been traditionally recommended for mild-to-moderate HV because of its simple and less invasive nature with fewer complications, faster postoperative recovery, and reliable outcomes. In recent years, the indications for this procedure have expanded to include HV with severe deformities. This study aimed to directly compare the efficacy of this procedure for HV patients with moderate deformity with that in patients with the severe form of this disorder.Materials and Methods.A retrospective review of medical records identified 99 feet from 94 patients that were treated with distal chevron osteotomy with a modified McBride procedure. These feet were divided by the preoperative HV angle (HVA) and intermetatarsal angle (IMA) into the moderate (M, 64 feet) and severe groups (S, 35 feet). Baseline demographic data, preoperative and postoperative radiographic parameters were analyzed.Results.No significant differences in age, sex, body mass index, operation time, and duration of follow-up were observed between the two groups. Postoperative radiographic parameters significantly improved in both groups after treatment. Mean HVA and IMA normalized to <15° and <9°, respectively, in both groups, indicating adequate deformity correction. Improvement in the sesamoid position was better in group M compared to that in group S. The recurrence rate in group S was higher than that in group M, without statisticalsignificance (p=0.24).Conclusion.Radiological outcomes suggested that distal chevron osteotomy with a modified McBride procedure was effective and reliable in managing severe HV deformity, despite the slightly higher recurrence rate in this form of HV. Complete reduction of the sesamoids should be further emphasized during the management of severe HV deformity.
Lifetime of ground conformational state determines the activity of structured RNA
Authors: Thompson Rhese , Carbaugh Derek , Nielsen Joshua , Witt Ciara , Meganck Rita , Rangadurai Atul , Zhao Bo , Bonin Jeffrey , Nicely Nathan , Marzluff William , Frank Aaron , Lazear Helen , Zhang Qi 
Published: May 2023

Abstract

Biomolecules continually sample alternative conformations. Consequently, even the most energetically favored ground conformational state has a finite lifetime. Here, we show that, in addition to the 3D structure, the lifetime of a ground conformational state determines its biological activity. Using hydrogen-deuterium exchange nuclear magnetic resonance spectroscopy, we found that Zika virus exoribonuclease-resistant RNA (xrRNA) encodes a ground conformational state with a lifetime that is ~105–107 longer than that of canonical base pairs. Mutations that shorten the apparent lifetime of the ground state without affecting its 3D structure decreased exoribonuclease resistance in vitro and impaired virus replication in cells. Additionally, we observed this exceptionally long-lived ground state in xrRNAs from diverse infectious mosquito-borne flaviviruses. These results demonstrate the biological significance of the lifetime of a preorganized ground state and further suggest that elucidating the lifetimes of dominant 3D structures of biomolecules may be crucial for understanding their behaviors and functions.
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Authors: Blázquez-Encinas Ricardo , García-Vioque Víctor , Caro-Cuenca Teresa , Moreno-Montilla María Trinidad , Mangili Federica , Alors-Pérez Emilia , Ventura Sebastian , Herrera-Martínez Aura D. , Moreno-Casado Paula , Calzado Marco A. , Salvatierra Ángel , Gálvez-Moreno María A. , Fernandez-Cuesta Lynnette , Foll Matthieu , Luque Raúl M. , Alcala Nicolas , Pedraza-Arevalo Sergio , Ibáñez-Costa Alejandro , Castaño Justo P 
Published: May 2023

Abstract
Background
Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low to intermediate malignancy and may be surgically managed, but show resistance to radiotherapy/chemotherapy in case of metastasis. Molecular profiling is providing new information to understand lung carcinoids, but its clinical value is still limited. Altered alternative splicing is emerging as a novel cancer hallmark unveiling a highly informative layer.
Methods
We primarily examined the status of the splicing machinery in lung carcinoids, by assessing the expression profile of the core spliceosome components and selected splicing factors in a cohort of 25 carcinoids using a microfluidic array. Results were validated in an external set of 51 samples. Dysregulation of splicing variants was further explored in silico in a separate set of 18 atypical carcinoids. Selected altered factors were tested by immunohistochemistry, their associations with clinical features were assessed and their putative functional roles were evaluated in vitro in two lung carcinoid-derived cell lines.
Results
The expression profile of the splicing machinery was profoundly dysregulated. Clustering and classification analyses highlighted five splicing factors: NOVA1, SRSF1, SRSF10, SRSF9 and PRPF8. Anatomopathological analysis showed protein differences in the presence of NOVA1, PRPF8 and SRSF10 in tumor versus non-tumor tissue. Expression levels of each of these factors were differentially related to distinct number and profiles of splicing events, and were associated to both common and disparate functional pathways. Accordingly, modulating the expression of NOVA1, PRPF8 and SRSF10 in vitropredictably influenced cell proliferation and colony formation, supporting their functional relevance and potential as actionable targets.
Conclusions
These results provide primary evidence for dysregulation of the splicing machinery in lung carcinoids and suggest a plausible functional role and therapeutic targetability of NOVA1, PRPF8 and SRSF10.
Glacier Surge in Central Himalaya: A topographical surprise
Authors: Rana Ajay Singh , Kumar Vinit , Mehta Manish , Rawat Gautam 
Published: May 2023

Abstract
Our understanding of glacier dynamics and climate variability in the Himalaya exhibits significant gaps and heterogeneity. In this study, high-resolution LISS-IV (2011, 2017, 2020) and Cartosat-1 (2011, 2012) PAN images with Landsat data in conjunction with SRTM, ASTER, and High Mountain Asia (HMA) digital elevations models (DEMs) were used to understand the surge behaviour of an unnamed glacier in central Himalaya. Based on observations of the glacier terminus fluctuation, area change, surface ice velocity (SIV), and surface elevation change from 2000–2022, a study revealed that an unnamed glacier exhibited surge behavior. Glacier's SIV increased from 2000–2020 and is declining after the surge. The SIV was 7.21 ± 3.01 m/yr in 2001-02 and 163.32 ± 0.60 during October 2019-20. In September-October 2019, there was a sudden and significant increase in SIV to 863 meters within a month, indicating the surging behaviour of the glacier. Overall, the results suggest that the glacier's velocity varied considerably during the observed period, with periods of gradual increase, sudden increase, and significant decrease. Further, the glacier surface elevation change suggests an overall mass gain of 0.26 ± 0.27 m/yr from 2000-20, with a temporary mass loss of -0.13 ± 0.41 between 2011 and 2015. In addition, two earthquakes, measuring 3.5 and 3.3 in magnitude, occurred near the glacier on March 9th, 2018, at midnight (12:06 AM) and morning (4:29 AM), respectively. We assumed that these events may have impacted to glacier's base, which had previously rested on sedimentary rocks. This, combined with glacier melting and subsequent earthquakes in 2018, likely altered the glacier's velocity threshold, leading to a surge. In this paper, we present a novel observation of a glacier surge in the central Tethyan Himalaya and attempt to identify the underlying processes driving the surge. This study represents the first reported occurrence of a glacier surge in the central Himalaya.
Timing dependent neuronal migration is regulated by Cdk5-meidated phosphorylation of JIP1
Authors: Fei Qinglin , Im Doo Soon , Huang Tianwen , Qu Dianbo 
Published: May 2023

Abstract
The evolution of the mammalian brain, particularly the cerebral cortex, is characterized by an increase in size and complexity. Proper development of the cerebral cortex involves several coordinated events such as differentiation and migration, which plays a critical role in establishing a precise six-layered architecture. Our previous study has shown that phosphorylation of JIP1 at T205 by Cdk5 affects the axonal outgrowth. However, the spatiotemporal expression patterns and functions of these three genes in different cell types during cortical development are not well understood. In this study, we interrogated single-cell RNA-sequencing (scRNA-seq) data of mouse embryonic cortex and revealed that Cdk5, Cdk5r1 (p35) and Mapk8ip1 (JIP1) are dynamically expressed in intermediate progenitors (IPs). Pseudotime analysis showed that the expression of these three genes increased simultaneously in IPs during neuronal migration and differentiation. By manipulating the expression of JIP1 and phospho-mimic JIP1 using in utero electroporation, we demonstrated that phosphorylated JIP1 at T205 influenced the temporal migration of neurons. Taken together with previous findings that phospho-JIP1 at T205 regulates axonal growth, our study reveals a mechanism by which Cdk5, p35, and JIP1 coordinate to regulate neuron specification in the developing neocortex.
Optimizing and selecting tool design of micro friction stir spot weld for corrugated sandwich panel applications
Authors: Amat Mohammad Azwar , Andhika I Dewa Gede Ryan , Pratama Faundra Ihsan , Kiswanto Gandjar , Baskoro Ario Sunar 
Published: May 2023

Abstract
Tool geometries and plunge depth play significant roles in the stirring process of micro friction stir spot weld (µFSSW). Those two variables affecting the hook and joint formation, which leads to the joint strength of a single spot weld. The present work investigates the influence of tool geometry and plunge depth on the weld's quality. Furthermore, the result from the investigation will be used for reference to optimize the tool's design in the future based on the joint strength characteristics. It is performed on a 0.42-mm-thick AA1100 lap-shear joint and investigates each tool's macrostructure and mechanical properties. There were seven tool designs and three plunge depth variations. The plunge depth was varied to determine the hook and joint formation evolution in each tool design using macrostructural studies and determine the best plunge depth for the highest tensile shear load. While the tool design variation investigates the influence of size and geometry on joint characteristics, finding the best geometry corresponds with the highest tensile shear load. Regression and prediction interval analysis is used for the tensile shear load (max. load). The result shows that the formation of a hook, such as a straight or bending shape, depends on the feature of the stir zone, which is affected by the tool's geometry. The hook shape and location would determine the possibility of crack propagation path and ultimately affect the max load.