bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training Humans to Detect Children's Lies Through Their Facial Expressions
Authors: O'Connor Alison M. , Gongola Jennifer , Bruer Kaila C. , Lyon Thomas D. , Evans Angela D. 
Published: January 2025

ABSTRACTThe accurate detection of children's truthful and dishonest reports is essential as children can serve as important providers of information. Research using automated facial coding and machine learning found that children who were asked to lie about an event were more likely to look surprised when hearing the first question during an interview about said event. The present studies explored if humans can be trained to look for surprised expressions to detect children's deception. Participants made lie‐detection judgments after seeing children's expressions in very brief clips. In Study 1, we compared performance across a training condition and control condition, and in Study 2 we modified the training. With training, adults could detect children's lies at above‐chance levels by viewing their facial expressions. Detection accuracy was further improved with modified training (Study 2), but participants held a consistent lie bias. Challenges with using facial expressions to detect deceit are discussed.
Mechanical Stimulus and Metabolic Responses by Cryo‐Printing Anisotropic Scaffolds for Achieving Promoted Bone Regeneration
Authors: Zhu Yuemeng , Li Yangyang , Yang Yixin , Lv Huixin , Ren Sicong , Zhang Yidi , Zhou Yanmin 
Published: January 2025

Abstract3D scaffolds are essential as they serve as extracellular matrix (ECM)‐like platforms to provide cells with mechanical support and facilitate their attachment for bone regeneration. As an emerging personalized treatment technology, 3D printing has been applied to treat irregular large‐area bone defects caused by diseases such as tumors and trauma. However, traditional printing methods cannot control the microstructure of the scaffolds for bone tissue engineering (BTE). Meanwhile, commercial materials often cause rejection reactions, limiting the osteogenic effect of 3D‐printed scaffolds. In this investigation, scaffolds with controllable micro‐ordered morphology are prepared through cryogenic 3D printing combined with ice template technology. The surface of the scaffold exhibits an ordered micrometer‐level structure that matches the growth direction of ice crystals, and the porosity of the scaffolds can be adjusted by the content of nano‐hydroxyapatite (HA). The biological studies reveal an increased osteogenesis and angiogenesis of the composite scaffolds. The anisotropic mechanical stimulation signal regulates metabolic patterns, which may be a potential mechanism for anisotropic scaffolds to promote osteogenic differentiation by regulating S1P/S1PR2/YAP metabolic pathway. This study unlocks the potential of this simple method to produce biomimetic anisotropic scaffolds to achieve multiple functions for BTE.
Phosphorus‐Mediated Selenium Dual Atoms for Bifunctional Oxygen Reactions and Long‐Life Low‐Temperature Energy Conversion
Authors: Xia Lingzhi , Zhang Jianhua , Yan Pengfei , Zhou Kai‐Ling , Jin Yuhong , Ke Xiaoxing , Liu Jingbin , Wang Hao 
Published: January 2025

AbstractRapid kinetics and stable atom configuration of the catalysts are essential and greatly sought after for bifunctional oxygen reactions and energy conversion devices, but remain unsatisfactory. Herein, the Se dual atoms structure consisting of the periodically arranged Se‐P‐Se configurations within graphitic nitrogen carbon framework (P‐Se dual atoms‐NC) is constructed by P directionally mediated single atoms deposition strategy. The in situ/ex situ experiments combining the theoretical calculations reveal that both the inter‐site distance effect of the adjacent Se atoms in the NC and the Se‐P binding effect endow P‐Se dual atoms‐NC with a stable atom configuration and ultra‐durable lifespan, and the locally polarized electronic micro‐environment built by P 2p‐Se 3d‐C 2p orbital hybridization and the electrons transfer significantly promotes H2O‐O2 coupling, boosts the adsorption/desorption of O‐intermediates and accelerates the electron transport kinetics. Moreover, the adjacent Se atoms with a periodically arranged structure could provide more sites for the absorption and conversion of reactants. Thus, the as‐prepared catalyst exhibits the top‐level bifunctional activity with an ultra‐low potential difference (ΔE) of 0.58 V and delivers the outstandingly low‐temperature specific capacity of 796.41 mAh gZn−1 and the ultra‐durable lifespan over 1000 h for assembled zinc‐air batteries at −40 °C.
Ultra‐Fast Moisture Sensor for Respiratory Cycle Monitoring and Non‐Contact Sensing Applications
Authors: Mandal Suman , Mantilla Harold Mazo , Loganathan Kalaivanan , Faber Hendrik , Sharma Abhinav , Gedda Murali , Yengel Emre , Goswami Dipak Kumar , Heeney Martin , Anthopoulos Thomas D. 
Published: January 2025

AbstractAs human‐machine interface hardware advances, better sensors are required to detect signals from different stimuli. Among numerous technologies, humidity sensors are critical for applications across different sectors, including environmental monitoring, food production, agriculture, and healthcare. Current humidity sensors rely on materials that absorb moisture, which can take some time to equilibrate with the surrounding environment, thus slowing their temporal response and limiting their applications. Here, this challenge is tackled by combining a nanogap electrode (NGE) architecture with chicked egg‐derived albumen as the moisture‐absorbing component. The sensors offer inexpensive manufacturing, high responsivity, ultra‐fast response, and selectivity to humidity within a relative humidity range of 10–70% RH. Specifically, the egg albumen‐based sensor showed negligible response to relevant interfering species and remained specific to water moisture with a room‐temperature responsivity of 1.15 × 104. The nm‐short interelectrode distance (circa 20 nm) of the NGE architecture enables fast temporal response, with rise/fall times of 10/28 ms, respectively, making the devices the fastest humidity sensors reported to date based on a biomaterial. By leveraging these features, non‐contact moisture sensing and real‐time respiratory cycle monitoring suitable for diagnosing chronic diseases such as sleep apnea, asthma, and pulmonary disease are demonstrated.
Ferrites with a Minimized Secondary Electron Yield
Authors: Uren Robin , Hoffman Manuel , Din Amin , Wackerow Stefan , Neupert Holger , Pfeiffer Stephan , Moros Alice , Barnes Michael , Favia Giorgia , Himmerlich Marcel , Abdolvand Amin 
Published: January 2025

AbstractFerrites are an essential material in modern industry due to their exceptional magnetic properties and high resistivity. Many applications of ferrites necessitate exposure to high energy electrons, particularly space science and particle accelerators, where charging, multipacting, and electron clouds (ECs) are major issues. ECs are of particular concern around the Ni/Zn soft ferrite kicker magnets as the large hadron collider (LHC) undergoes its high luminosity upgrade. Here, laser engineered surface structures (LESS) are used to reduce the secondary electron yield (SEY) of Ni/Zn ferrites from 2.1 to its experimentally determined minimum of 0.81, eliminating the ferrites ability to contribute to the formation of ECs. This demonstrates the applicability of LESS outside of metals and its broader applicability to reducing the SEY of technical materials.
Nanocapsuled Neutrophil Extracellular Trap Scavenger Combating Chronic Infectious Bone Destruction Diseases
Authors: Tao Siying , Yang Yingming , Wu Chenzhou , Yang Jiaojiao , Wang Ziyou , Zhou Fangjie , Liang Kunneng , Deng Yi , Li Jianshu , Li Jiyao 
Published: January 2025

AbstractChronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the bone loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative. The retention of neutrophil extracellular traps (NETs) in chronic infectious niches is found to be a barrier to inflammation resolution. However, whether ruining the existing NETs within the local infectious bone lesions can contribute to inflammation resolve and bone repair remains understudied. Herein, a nanocapsuled delivery system that scavenges NETs dual‐responsively to near‐infrared light as a switch and to NETs themselves as a microenvironment sensor is designed. Besides, the photothermal and photodynamic effects endow the nanocapsules with antibacterial properties. Together with the ability to clear NETs, these features facilitate the restoration of the normal host response. The immunocorrective properties and inherent pro‐osteogenic effects finally promote local bone repair. Together, the NET scavenging nanocapsules address the challenge of impaired bone repair in chronic infections due to biased host response caused by excessive NETs. This study provides new concepts and strategies for repairing bone destruction attributable to chronic infections via correcting biased host responses in chronic infectious diseases.
Plastic Deformation of LiNi0.5Mn1.5O4 Single Crystals Caused by Domain Orientation Dynamics
Authors: Vostrov Nikita , Martens Isaac , Colalongo Mattia , Zatterin Edoardo , Ronovsky Michal , Boulineau Adrien , Leake Steven , Zhu Xiaobo , Wang Lianzhou , Richard Marie‐Ingrid , Schulli Tobias 
Published: January 2025

AbstractThe nanoscale mechanisms of ion deintercalation in battery cathode materials remain poorly understood, especially the relationship between crystallographic defects (dislocations, small angle grain boundaries, vacancies, etc), device performance, and durability. In this work, operando scanning X‐ray diffraction microscopy (SXDM) and multi‐crystal X‐ray diffraction (MCXD) are used to investigate microstrain and lattice tilt inhomogeneities inside Li1 − x
Ni0.5Mn1.5O4 cathode particles during electrochemical cycling and their influence on the material degradation. Using these techniques, microscale lattice degradation mechanisms are investigated inside single crystals, extend it to an inter‐particle scale, and correlate it with the long‐term degradation of the cathode. During cycling, a crystal lattice deformation is observed, associated with phase transitions and inherent lattice defects in the measured particle. Residual misorientations are observed in the structure even after full discharge, indicating an irreversible structural change of the lattice. However, after long‐term cycling such lattice misorientations together with active material dissolution are further exacerbated only in a subset of particles, suggesting high heterogeneity of degradation mechanisms between the cathode particles. Selective degradation of particles could be caused by varying crystal quality across the sample, highlighting the need for a deep understanding of defect microstructures to enable a more rational design of materials with enhanced durability.
Fertilizer selection influences soil microbial communities in alluvial and peat soils of the tropics
Authors: Widiastuti Dwi P. , Afkairin Antisar , Stromberger Mary , Gafur Sutarman , Davis Jessica G. 
Published: January 2025

AbstractFertilizer choices can alter soil microbial communities. The objective of this study was to determine the effects of urea, chicken manure, and Azolla fertilizers on soil microbial communities in alluvial and peat soils in West Kalimantan, Indonesia. Five nitrogen (N) fertilizer treatments were applied to spinach (Amaranthus tricolor) grown on both soil types: control (0 kg N ha−1), urea (23 kg N ha−1), Azolla applied at the same urea‐N rate (Azolla‐U, 23 kg N ha−1), chicken manure (108 kg N ha−1), and Azolla applied at the same manure‐N rate (Azolla‐M, 108 kg N ha−1). Microbial community structure was determined from freeze‐dried soil samples (0–20 cm deep) by the ester‐linked fatty acid methyl ester (EL‐FAME) method and analyzed by gas chromatography–mass spectrometry. Treatment effects were dependent upon soil type. In peat soil, fertilizer treatment influenced the abundance of Gram‐positive bacteria, whereas in alluvial soil, fertilizer affected the population of Gram‐negative bacteria. In alluvial soil, Azolla‐M increased EL‐FAMEs for total microbial biomass, Gram‐negative bacteria, and arbuscular mycorrhizal fungi. On the other hand, in the peat soil, Azolla‐M had a significant effect on altering the microbial community structure toward greater fungal biomass, while urea increased the number of Gram‐positive bacteria and actinomycetes. Azolla‐M altered the Gram‐positive:Gram‐negative ratio and reduced the Stress 2 ratio in the peat soil, but the manure and the lower application of Azolla (Azolla‐U) did not. Azolla‐M may diminish stress encountered by the microbial community from unfavorable environmental conditions.
Synthesis of Substituted Furans from β‐Ketoanilides Using Ethylene Glycol as C2‐Precursor
Authors: Maity Sujit , Panda Niranjan 
Published: January 2025

AbstractA transition‐metal‐free oxidative method to synthesize substituted furans from β‐ketoanilides and vicinal diols was reported. This approach accommodates a wide range of functional groups (e. g., halogens, methoxy, methyl, nitro) and enables the regioselective formation of 2,3‐disubstituted and 2,3,5‐trisubstituted furans via base‐promoted oxidative C−C and C−O bond formation. Additionally, substituted pyrroles were synthesized regioselectively from β‐ketoenamines using ethylene glycol as a C2 precursor.
Flavoenzyme‐inspired Reductive Dehalogenation of α‐Br and α‐Cl Carbonyl Compounds with Riboflavin Tetraacetate as Photocatalyst
Authors: Zhang Xuan , Jin Ge , Zhang Qin , Sun Chaoyue , Han Yun , Dou Changbin , Yuan Zhaoyi , Xia Lingyu , Yun Shu , Chao Mianran , Shen Duyi 
Published: January 2025

AbstractReductive dehalogenation represented a straightforward way to the breakage of carbon‐halogen bonds, exerting great significance in organic synthesis and potential in environmental decontamination. Riboflavin, a small molecular, photosensitive, and redox‐responsible coenzyme in both oxidases and reductase, has inspired various biological and biomimetic photocatalytic oxidations but a few biocatalytic reductions. Herein, we described a visible‐light‐induced reduction of C−Br and C−Cl bonds to form C−H bonds using riboflavin tetraacetate (RFT) as a flavoenzyme‐inspired photocatalyst. The halogen atoms of α‐bromo‐ and α‐chloro carbonyl compounds could be smoothly removed at room temperature with triethanolamine as a suitable terminal reductant and a sustainable solvent system consisting of ethanol and water. A series of deuterium isotope labeling experiments indicated that the hydrogen atom sources of the dehalogenated products should be water, reductant, and the hydroxyl group rather than the α‐hydrogen atom of the alcoholic solvent. Other control experiment and UV‐Vis studies suggested the single electron transfer process between the excited photocatalyst and the reductant, the reduced photocatalyst and the C−X bond, respectively. This work further tapped the versatile capacities of riboflavin‐based photocatalysts in chemical reductions more than conventional oxidative reactions.
Plasma N‐terminal tau fragment is an amyloid‐dependent biomarker in Alzheimer's disease
Authors: Lan Guoyu , Zhang Laihong , Li Anqi , Ran Wenqing , Lv Jieqin , Gonzalez‐Ortiz Fernando , Cai Yue , Sun Pan , Liu Lin , Yang Jie , He Zhengbo , Fang Lili , Zhou Xin , Zhu Yalin , Liu Zhen , Chen Xuhui , Fan Xiang , Shi Dai , Ye Chenghui , Xu Linsen , Wang Qingyong , Blennow Kaj , Cheng Guanxun ,   for the Alzheimer's Disease Neuroimaging Initiative, Ran Pengcheng , Wang Lu , Guo Tengfei 
Published: January 2025

AbstractINTRODUCTIONNovel fluid biomarkers for tracking neurodegeneration specific to Alzheimer's disease (AD) are greatly needed.METHODSUsing two independent well‐characterized cohorts (n = 881 in total), we investigated the group differences in plasma N‐terminal tau (NT1‐tau) fragments across different AD stages and their association with cross‐sectional and longitudinal amyloid beta (Aβ) plaques, tau tangles, brain atrophy, and cognitive decline.RESULTSPlasma NT1‐tau significantly increased in symptomatic AD and displayed positive associations with Aβ PET (positron emission tomography) and tau PET. Higher baseline NT1‐tau levels predicted greater tau PET, with 2‐ to 10‐year intervals and faster longitudinal Aβ PET increases, AD‐typical neurodegeneration, and cognitive decline. Plasma NT1‐tau showed negative correlations with baseline regional brain volume and thickness, superior to plasma brain‐derived tau (BD‐tau) and neurofilament light (NfL) in Aβ‐positive participants.DISCUSSIONThis study suggests that plasma NT1‐tau is an Aβ‐dependent biomarker and outperforms BD‐tau and NfL in detecting cross‐sectional neurodegeneration in the AD continuum.Highlights
Plasma N‐terminal tau (NT1‐tau) was specifically increased in the A+/T+ stage.
Plasma NT1‐tau was positively associated with greater amyloid beta (Aβ) and tau PET (positron emission tomography) accumulations.
Higher plasma NT1‐tau predicted greater tau burden and faster Aβ increases.
Plasma NT1‐tau was more related to neurodegeneration than plasma brain‐derived tau (BD‐tau) and neurofilament light (NfL).
Multi‐Targeting Makrozyklische Peptide als Nanomolare Inhibitoren der Selbst‐ und Kreuznukleation der Amyloiden Selbstassemblierung von α‐Synuclein
Authors: Hornung Simon , Vogl Dominik P. , Naltsas Denise , Volta Beatrice Dalla , Ballmann Markus , Marcon Beatrice , Syed Muhammed Muazzam Kamil , Wu Yiyang , Spanopoulou Anna , Feederle Regina , Heidrich Luzia , Bernhagen Jürgen , Koeglsperger Thomas , Höglinger Günter U. , Rammes Gerhard , Lashuel Hilal A. , Kapurniotu Aphrodite 
Published: January 2025

AbstractDie amyloide Selbstassemblierung von α‐Synuclein (αSyn) wird mit der Pathogenese der Parkinson‐Krankheit (PD) in Verbindung gebracht. Typ 2 Diabetes (T2D) hat sich kürzlich als Risikofaktor für PD herausgestellt. Kreuzinteraktionen zwischen den amyloidogenen Proteinen der beiden Erkrankungen könnten eine molekulare Verbindung darstellen. Tatsächlich können Fibrillen des Inselamyloid‐Polypeptids (IAPP) bei T2D als Nukleus für die Amyloidbildung von αSyn fungieren. Auch wurde berichtet, dass αSyn und IAPP in Gehirnen von PD‐Patienten co‐lokalisieren. Daher könnte die Hemmung sowohl der selbst‐ als auch der IAPP‐vermittelten Kreuznukleation der αSyn‐Amyloidbildung möglicherweise mit der PD‐Pathogenese interferieren. In dieser Studie zeigen wir, dass makrozyklische Peptide, die IAPP‐Selbst‐ und Kreuzinteraktionsstellen nachahmen und sich zuvor als Inhibitoren der Amyloidogenese des IAPP und/oder des Amyloid‐β‐Peptids Aβ40(42) der Alzheimer‐Krankheit (AD) erwiesen haben, auch nanomolare Inhibitoren der selbst‐ bzw. der IAPP‐nukleierten Amyloidogenese von αSyn sind. Ihre Anti‐Amyloid‐Wirkung wird durch ihre Bindung mit nanomolarer Affinität an drei αSyn‐Regionen vermittelt. Letztere werden als Schlüsselregionen sowohl für die αSyn‐Selbstassemblierung als auch für seine Kreuzwechselwirkungen mit IAPP identifiziert. Darüber hinaus zeigen wir, dass diese Peptide auch die Aβ42‐vermittelte Kreuznukleation der αSyn‐Amyloidogenese hemmen können. Auf der Basis ihres breiten Anti‐Amyloid‐Wirkspektrums und zusätzlicher wirkstoffähnlicher Eigenschaften, stellen diese Peptide Leitstrukturen für multifunktionale Anti‐Amyloid‐Wirkstoffe bei PD, T2D, AD und deren Komorbiditäten dar. Darüber hinaus sind die identifizierten αSyn‐Schlüsselsegmente wertvolle Ziele für neuartige, an mehreren αSyn‐Stellen angreifende Amyloidinhibitoren bei PD und verwandten Synucleinopathien.
Dry‐Solid‐Electrochemical Synthesis: A General Method for Large Scale Synthesis of Single‐Atom Catalysts with High Metal loadings
Authors: Gong Xue , Bao Jinpeng , Wang Xian , Wan Xin , Gu Yaheng , Han Ce , Shui Jianglan , Su Xiaozhi , Ge Junjie , Xing Wei , Song Ping , Xu Weilin 
Published: January 2025

AbstractSingle‐atom catalysts (SACs) with high metal loadings are highly desirable but still challenging for large scale synthesis. Here we report a new technique named as dry‐solid‐electrochemical synthesis (DSES) for a general large‐scale synthesis of SACs with high metal loadings in an energy‐conservation and environment‐friendly way. With it, a series of pure carbon‐supported metal SACs (Platinum up to 35.0 wt %, Iridium 21.2 wt %, Ruthenium 20.4 wt % and Iron 17.6 wt %) with high metal loadings were obtained. Particularly, a Pt SAC with Pt 23.9 wt % and remarkable oxygen reduction reaction (ORR) performance in fuel cells is synthesized on kilogram scale. Based on multiple control experiments, a unique redox mechanism for DSES process is proposed: metal precursors on conductive supports are reduced to metals via a homolytic cleavage of metal‐halogen bonds by the attacking of electrons flowing through the dry solid phase. Such versatile technique paves a new economical and environment‐friendly pathway for fabricating high‐metal‐loading SACs or atomic dispersion catalysts.
Multi‐Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self‐ and Cross‐Seeded Amyloid Self‐Assembly of α‐Synuclein
Authors: Hornung Simon , Vogl Dominik P. , Naltsas Denise , Volta Beatrice Dalla , Ballmann Markus , Marcon Beatrice , Syed Muhammed Muazzam Kamil , Wu Yiyang , Spanopoulou Anna , Feederle Regina , Heidrich Luzia , Bernhagen Jürgen , Koeglsperger Thomas , Höglinger Günter U. , Rammes Gerhard , Lashuel Hilal A. , Kapurniotu Aphrodite 
Published: January 2025

AbstractAmyloid self‐assembly of α‐synuclein (αSyn) is linked to the pathogenesis of Parkinson's disease (PD). Type 2 diabetes (T2D) has recently emerged as a risk factor for PD. Cross‐interactions between their amyloidogenic proteins may act as molecular links. In fact, fibrils of islet amyloid polypeptide (IAPP) (T2D) can cross‐seed αSyn amyloidogenesis and αSyn and IAPP colocalize in PD brains. Inhibition of both self‐ and IAPP‐cross‐seeded αSyn amyloidogenesis could thus interfere with PD pathogenesis. Here we show that macrocyclic peptides, designed to mimic IAPP self‐/cross‐interaction sites and previously found to inhibit amyloidogenesis of IAPP and/or Alzheimer's disease (AD) amyloid‐β peptide Aβ40(42), are nanomolar inhibitors of both self‐ and IAPP‐cross‐seeded amyloid self‐assembly of αSyn. Anti‐amyloid function is mediated by nanomolar affinity interactions with αSyn via three αSyn regions which are identified as key sites of both αSyn self‐assembly and its cross‐interactions with IAPP. We also show that the peptides block Aβ42‐mediated cross‐seeding of αSyn as well. Based on their broad spectrum anti‐amyloid function and additional drug‐like features, these peptides are leads for multifunctional anti‐amyloid drugs in PD, T2D, AD, and their comorbidities, while the identified αSyn key segments are valuable targets for novel, multi‐site targeting amyloid inhibitors in PD and related synucleinopathies.