bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfer of maternal immunity using a polyvalent vaccine and offspring protection in Nile tilapia, Oreochromis niloticus
Authors: Amrullah Amrullah , Wahidah Wahidah , Ardiansyah Ardiansyah , Indrayani Indrayani 
Published: March 2023

Background: Vaccination is an effective and alternative means of disease prevention, however, it cannot be conducted on the offspring of fish. For this process to take place, the transfer of maternal immunity must be implemented. This study aims to determine the effectiveness of transferring immunity from the broodstock to the offspring using a polyvalent vaccine against Aeromonas hydrophila, Streptococcus agalactiae, and Pseudomonas fluorescens in Nile tilapia, Oreochromis niloticus. Methods: Nile tilapia broodstock, with an average weight of 203g (±SD 23 g) was injected with a vaccine used as a treatment. Example include A. hydrophila monovalent (MA), S. agalactiae monovalent (MS), P. fluorescens monovalent (MP), A. hydrophila and S. agalactiae bivalent (BAS), A. hydrophila and P. fluorescens bivalent (BAP), P. fluorescens and S. agalactiae bivalent (BPS), and A. hydrophila, S. agalactiae, and P. fluorescens polyvalent vaccines (PAPS). While the control was fish that were injected with a PBS solution. The broodstock’s immune response was observed on the 7th, 14th, 21st, and 28th day, while the immune response and challenge test on the offspring was conducted on the 10th, 20th, 30th, and 40th day during the post-hatching period. Result: The application of PAPS in broodstock could significantly induce the best immune response and immunity to multiple diseases compared to other treatments. The RPS of the PAPS was also higher than the other types of vaccines. This showed that the transfer of immunity from the broodstock to the Nile tilapia offspring could protect it against bacterial diseases such as A. hydrophila, S. agalactiae, and P. fluorescens. Conclusion: The application of PAPS A. hydrophila, S. agalactiae, P. fluorescens vaccines increased the broodstock’s immune response and it was transferred to their offsprings. They were able to produce tilapia seeds that are immune to diseases caused by A. hydrophila, S. agalactiae, and P. fluorescens.
Skończoność a zło. W stronę Jeana Naberta
Authors: Jakubowski Jarosław 
Published: March 2023

Nabertowskie ujęcie relacji „skończoność-zło” jest o tyle intrygujące, że wbrew utrwalonemu w wielowiekowej tradycji poglądowi zakłada, że to skończoność jest uwarunkowana przez zło, a nie odwrotnie. Uzasadniając swój pogląd Nabert prezentuje pogłębioną analizę egzystencjalnych warunków możliwości czynienia zła. Zwraca on uwagę, że pomimo iż mamy poczucie wolnej woli, to okazuje się ono iluzoryczne, gdyż nie jesteśmy w stanie uchwycić źródeł własnych działań. Zdaniem Naberta, niezdolność do ich uchwycenia nie stanowi jednak najbardziej pierwotnego warunku możliwości czynienia zła. Warunku tego należy poszukiwać bowiem w konstytuującym naszą egzystencję źródłowym rozdźwięku, zachodzącym między „Ja empirycznym” a „Ja czystym”, czyli w „alienacji fundamentalnej” Wszelkie cechujące nas ograniczenia są wtórne wobec zła generowanego poprzez ten rozdźwięk, w tym właśnie sensie zło poprzedza skończoność. Aby podważyć wskazany wyżej prymat zła nad skończonością, trzeba by rozszerzyć znaczenie pojęcia skończoności uznając, że sama alienacja fundamentalna również może być kwalifikowana jako skończoność. Nawet jednak w takim przypadku pozostałaby do rozstrzygnięcia kwestia specyficznego typu zła (wskazywanego przez Naberta w dziele Le Désir de Dieu) polegającego na odmowie podejmowania wysiłku przezwyciężenia alienacji fundamentalnej. Odmowa taka może być wszakże odczytywana jako czynnik nie tylko potęgujący tę alienację, ale w ostatecznym rozrachunku jako czynnik warunkujący ją.
Resgatando o pensamento econômico e social latino-americano: uma revisão das perspectivas da dependência de Ruy Mauro Marini e Celso Furtado
Authors: Serwy Gabriel Rolemberg 
Published: March 2023

A discussão sobre desenvolvimento e o subdesenvolvimento na América Latina teve como um de seus principais referenciais teóricos as perspectivas que davam centralidade à dependência. O objetivo deste trabalho é resgatar duas das principais abordagens produzidas utilizando esse conceito – as de Ruy Mauro Marini e Celso Furtado. O resgate é feito em dois momentos: primeiramente, por meio de uma análise em separado de obras de referência destes autores, descrevendo inovações teóricas que essas leituras sugerem no entendimento do subdesenvolvimento dos países latino-americanos. Logo em seguida, parte-se para uma abordagem comparativa de seus aspectos teóricos e metodológicos. Em vista da dificuldade contemporânea em abordar a discussão do subdesenvolvimento por meio de leituras mais afinadas com as particularidades latino-americanas, o presente trabalho pode contribuir para o enriquecimento das discussões do desenvolvimento na atualidade e trazer novamente à tona antigos problemas intelectuais esquecidos ou abandonados sem a devida consideração mais aprofundada que merecem desde a época em que foram formulados.
Systemic glucose-insulin-potassium reduces skeletal muscle injury, kidney injury, and pain in a murine ischaemia-reperfusion model
Authors: Buchalter Daniel B. , Kirby David J. , Anil Utkarsh , Konda Sanjit R. , Leucht Philipp 
Published: March 2023

AimsGlucose-insulin-potassium (GIK) is protective following cardiac myocyte ischaemia-reperfusion (IR) injury, however the role of GIK in protecting skeletal muscle from IR injury has not been evaluated. Given the similar mechanisms by which cardiac and skeletal muscle sustain an IR injury, we hypothesized that GIK would similarly protect skeletal muscle viability.MethodsA total of 20 C57BL/6 male mice (10 control, 10 GIK) sustained a hindlimb IR injury using a 2.5-hour rubber band tourniquet. Immediately prior to tourniquet placement, a subcutaneous osmotic pump was placed which infused control mice with saline (0.9% sodium chloride) and treated mice with GIK (40% glucose, 50 U/l insulin, 80 mEq/L KCl, pH 4.5) at a rate of 16 µl/hr for 26.5 hours. At 24 hours following tourniquet removal, bilateral (tourniqueted and non-tourniqueted) gastrocnemius muscles were triphenyltetrazolium chloride (TTC)-stained to quantify percentage muscle viability. Bilateral peroneal muscles were used for gene expression analysis, serum creatinine and creatine kinase activity were measured, and a validated murine ethogram was used to quantify pain before euthanasia.ResultsGIK treatment resulted in a significant protection of skeletal muscle with increased viability (GIK 22.07% (SD 15.48%)) compared to saline control (control 3.14% (SD 3.29%)) (p = 0.005). Additionally, GIK led to a statistically significant reduction in gene expression markers of cell death (CASP3, p < 0.001) and inflammation (NOS2, p < 0.001; IGF1, p = 0.007; IL-1β, p = 0.002; TNFα, p = 0.012), and a significant reduction in serum creatine kinase (p = 0.004) and creatinine (p < 0.001). GIK led to a significant reduction in IR-related pain (p = 0.030).ConclusionSystemic GIK infusion during and after limb ischaemia protects murine skeletal muscle from cell death, kidneys from reperfusion metabolites, and reduces pain by reducing post-ischaemic inflammation.Cite this article: Bone Joint Res 2023;12(3):212–218.
Oral and emotional health experience of refugees’ in the state of Massachusetts - A mixed methods approach
Authors: Aldukhail Shaikha , Shukla Anubhuti , Khadra Mohammad Tareq , Al Hennawi Ziad , Jordan Samantha , Cadet Tamara J. , Alqaderi Hend 
Published: March 2023

Objectives
In this study, we aimed to explore the oral and emotional health challenges experienced by a sample of refugees in Massachusetts across different stages of resettlement using a mixed methods approach.

Methods
We collaborated with two Federally Qualified Health Centers to identify and recruit participants for either surveys (n = 69) or semi-structured interviews (n = 12). Data collection was conducted in 2018. We performed descriptive statistics using STATA 14, and analyzed the interviews using qualitative methods.

Results
Overall, cost and lack of structure were the largest barriers identified for accessing dental care in participants’ home and host countries. In the US, participants reported receiving state-provided public health insurance, but still experienced disrupted access to dental care due to coverage limitations. We identified several mental health risk factors that may affect participants’ oral health, including trauma, depression, and sleeping problems. Despite these challenges, participants also identified areas of resilience and adaptability in both attitude and actions.

Conclusions
The themes identified in our study suggest that refugees have attitudes, beliefs, and experiences that contribute to their perspectives on oral health care. While some of the reported barriers to access dental care were attitudinal, others were structural. Access to dental care in the US was reported to be structured and available, but with limited coverage issues. This paper underscores the oral and emotional health aspects of refugees for future considerations and planning of appropriate, affordable and cost-effective policies in the global health care systems.
A cross-sectional analysis of the predictors of COVID-19 vaccine uptake and vaccine hesitancy in Iraq
Authors: Alatrany Saad S. J. , Falaiyah Ashraf Muwafa , Zuhairawi Raheem Hammlee Maarij , Ogden Ruth , ALi Sayyid ALdrraji ‏Hasan , Alatrany Abbas S. S. , Al-Jumeily Dhiya 
Published: March 2023

Background
Vaccine hesitancy poses a significant risk to global recovery from COVID-19. To date however, there is little research exploring the psychological factors associated with vaccine acceptability and hesitancy in Iraq.

Aim
To explore attitudes towards COVID-19 vaccination in Iraq. To establish the predictors of vaccine uptake and vaccine hesitancy in an Iraqi population.

Methods
Using a cross-sectional design, 7,778 participants completed an online questionnaire exploring their vaccination status, likelihood of infection, perceived severity infection, benefits of vaccine, barriers to vaccine, anticipated regret, subjective norms, and trust in government.

Findings
Vaccination rates increased with age and were greater in males, those who were married, divorced or widowed, those with children and those with underlying conditions. Vaccine hesitancy was widespread with 61.40% of unvaccinated individuals reported an unwillingness to receive a COVID-19 vaccine. In unvaccinated groups, vaccine hesitancy was associated with lower trust in the government, more negative social norms, greater perceived barriers to vaccination and reduced perceived benefits.

Conclusions
There is significant COVID-19 vaccine hesitancy in Iraq. Public health institutions should be aware of the influence of demographic factors, as well as personal beliefs and social norms, on individuals’ decisions to vaccinate. Public health messaging should therefore aim to be tailored to address the concerns of citizens.
Prevalence and factors associated with pediatric HIV therapy failure in a tertiary hospital in Asmara, Eritrea: A 15-year retrospective cohort study
Authors: Mengistu Samuel Tekle , Ghebremeskel Ghirmay Ghebrekidan , Achila Oliver Okoth , Abrehe Miriam Berhane , Tewelde Samuel Fisseha , Idris Mahmud Mohammed , Tikue Tsegereda Gebrehiwot , Mesfin Araia Berhane 
Published: March 2023

Introduction
Treatment failure (TF) in HIV infected children is a major concern in resource-constrained settings in Sub-Saharan Africa (SSA). This study investigated the prevalence, incidence, and factors associated with first-line cART failure using the virologic (plasma viral load), immunologic and clinical criteria among HIV-infected children.

Methods
A retrospective cohort study of children (<18 years of age on treatment for a period of > 6 months) enrolled in the pediatric HIV/AIDs treatment program at Orotta National Pediatric Referral Hospital from January 2005 to December 2020 was conducted. Data were summarized using percentages, medians (± interquartile range (IQR)), or mean ± standard deviation (SD). Where appropriate, Pearson Chi-Squire (χ2) tests or Fishers exacts test, Kaplan–Meier (KM) estimates, and unadjusted and adjusted Cox-proportional hazard regression models were employed.

Results
Out of 724 children with at least 24 weeks’ follow-up 279 experienced therapy failure (TF) making prevalence of 38.5% (95% CI 35–42.2) over a median follow-up of 72 months (IQR, 49–112 months), with a crude incidence of failure of 6.5 events per 100- person-years (95% CI 5.8–7.3). In the adjusted Cox proportional hazards model, independent factors of TF were suboptimal adherence (Adjusted Hazard Ratio (aHR) = 2.9, 95% CI 2.2–3.9, p < 0.001), cART backbone other than Zidovudine and Lamivudine (aHR = 1.6, 95% CI 1.1–2.2, p = 0.01), severe immunosuppression (aHR = 1.5, 95% CI 1–2.4, p = 0.04), wasting or weight for height z-score < -2 (aHR = 1.5, 95% CI 1.1–2.1, p = 0.02), late cART initiation calendar years (aHR = 1.15, 95% CI 1.1–1.3, p < 0.001), and older age at cART initiation (aHR = 1.01, 95% CI 1–1.02, p < 0.001).

Conclusions
Seven in one hundred children on first-line cART are likely to develop TF every year. To address this problem, access to viral load tests, adherence support, integration nutritional care into the clinic, and research on factors associated with suboptimal adherence should be prioritized.
Integration of evidence into Theory of Change frameworks in the healthcare sector: A rapid systematic review
Authors: Romão Davi Mamblona Marques , Setti Cecilia , Arruda Leo Heikiti Maeda , de Melo Roberta Crevelário , de Araujo Bruna Carolina , Tan Audrey R. , DeMaio Peter Nichols , Kuchenmüller Tanja 
Published: March 2023

Background
Theory of Change (ToC) has become an established approach to design and evaluate interventions. While ToC should—in line with the growing international focus on evidence-informed health decision-making–consider explicit approaches to incorporate evidence, there is limited guidance on how this should be done. This rapid review aims to identify and synthesize the available literature on how to systematically use research evidence when developing or adapting ToCs in the health sector.

Methods
A rapid review methodology using a systematic approach, was designed. Eight electronic databases were consulted to search for peer-reviewed and gray publications detailing tools, methods, and recommendations promoting the systematic integration of research evidence in ToCs. The included studies were compared, and the findings summarized qualitatively into themes to identify key principles, stages, and procedures, guiding the systematic integration of research evidence when developing or revising a ToC.

Results
This review included 18 studies. The main sources from which evidence was retrieved in the ToC development process were institutional data, literature searches, and stakeholder consultation. There was a variety of ways of finding and using evidence in ToC. Firstly, the review provided an overview of existing definitions of ToC, methods applied in ToC development and the related ToC stages. Secondly, a typology of 7 stages relevant for evidence integration into ToCs was developed, outlining the types of evidence and research methods the included studies applied for each of the proposed stages.

Conclusion
This rapid review adds to the existing literature in two ways. First, it provides an up-to-date and comprehensive review of the existing methods for incorporating evidence into ToC development in the health sector. Second, it offers a new typology guiding any future endeavors of incorporating evidence into ToCs.
An exact bifurcation diagram for ap-qLaplacian boundary value problem
Authors: Acharya Ananta , Munoz Victor , Nichols Dustin , Shivaji Ratnasingham 
Published: March 2023

We study positive solutions to thep–qLaplacian two-point boundary value problem:{−μ[(u′)p−1]′−[(u′)q−1]′=λu(1−u)on (0,1)u(0)=0=u(1)whenp=4andq=2. Hereλ>0is a parameter andμ≥0is a weight parameter influencing the higher-order diffusion term. Whenμ=0(the Laplacian case) the exact bifurcation diagram for a positive solution is well-known, namely, whenλ≤π2there are no positive solutions, and forλ>π2there exists a unique positive solutionuλ,μsuch that‖uλ,μ‖∞→0asλ→π2and‖uλ,μ‖∞→1asλ→∞. Here, we will prove that for allμ>0similar bifurcation diagrams preserve, and they all bifurcate from(λ,u)=(π2,0). Our results are established via the method of sub-super solutions and a quadrature method. We also present computational evaluations of these bifurcation diagrams for various values ofμand illustrate how they evolve whenμvaries.
Modeling Wolbachia infection frequency in mosquito populations via a continuous periodic switching model
Authors: Shi Yantao , Zheng Bo 
Published: March 2023

Abstract
In this article, we develop a continuous periodic switching model depicting Wolbachia infection frequency dynamics in mosquito populations by releasing Wolbachia-infected mosquitoes, which is different from the discrete modeling efforts in the literature. We obtain sufficient conditions on the existence of a unique and exactly two periodic solutions and analyze the stability of each periodic solution, respectively. We also provide a brief discussion and several numerical examples to illustrate our theoretical results.
Prenatal hydrometrocolpos as an unusual finding in Fraser syndrome. Case report
Authors: Dávila Neri Isabella , Farias Vela Adriana Patricia , Aragón Mendoza Rafael Leonardo , Gallo Roa Roberto , Russo Vizcaino Giovanni Carlo 
Published: March 2023

Abstract

Objectives
Fraser syndrome is a rare congenital malformation characterized by cryptophthalmos, syndactyly and urogenital tract malformations. The association with hydrometrocolpos is infrequent, with only a few cases reported in the literature.

Case presentation
A 19-year-old primigravida presenting at 35 weeks of gestation, with prenatal finding of hydrometrocolpos associated with hypotelorism and microphthalmia. Pre-term cesarean delivery was performed due to breech labor and perinatal death. The autopsy confirmed hydrometrocolpos secondary to vaginal atresia and imperforate hymen, associated with cryptophthalmos, syndactyly, nasal and pinna malformations, confirming the diagnosis of Fraser syndrome.

Conclusions
Fraser syndrome is usually a postnatal diagnosis. The association with genital abnormalities explains the finding of hydrometrocolpos, which could be considered a diagnostic criterion for this syndrome.
Warum und wie Typoskripte analysieren?
Authors: Fink Kristina 
Published: March 2023

Abstract
After a look at the history of typewriter development and in particular at its significance for the poet’s mode of production, two fundamentally different ‘writing settings’ are distinguished with regard to the interplay of the triad ‘producer – instrument – product’, which depend on the question about whether the poet himself operates the typewriter. For both writing settings, various examples are given, and positions of writers are examined in more detail. Based on the particular challenges of typescript analysis, a systematic catalogue is developed that explains the different categories as well as their respective specific potential for insight. On the basis of three selected examples from the digital historical-critical edition of Arthur Schnitzler’s late works, these research methods are finally applied in concreto to illustrate their added value for the reconstruction of text genesis in typescripts.
Measuring spatiotemporal accessibility to healthcare with multimodal transport modes in the dynamic traffic environment
Authors: Zhou Xinxin , Yuan LinWang , Wu Changbin , Yu Zhaoyuan , Lei Wang 
Published: March 2023

Abstract
Research on healthcare accessibility is developing with a focus on multimodal transport modes (MTMs) and multiple time-series variations. A dynamic traffic environment leads travelers to make distinct decisions at different time slots, which impacts spatiotemporal accessibility markedly. Our article proposes a methodological framework to measure spatiotemporal accessibility with multimodal transportation modes and its variation at multiple time series, while accounting for traffic congestion and the probability of residential transport mode choices in a dynamic traffic environment. We selected Nanjing, China, as the study area and pediatric clinic services (PCS) as specific healthcare services to estimate the spatiotemporal accessibility at four representative time slots. The results indicate that the weight estimation of travel time based on MTMs is more propitious than the travel time of single-mode to present real-world travel characteristics and reflects the spatiotemporal distribution and variation of services synthetically. Furthermore, the spatiotemporal accessibility variation of PCS in peripheral suburbs is more pronounced than that in urban centers and rural areas. This work holds pragmatic implications for policymakers in terms of services planning and allocation optimization to improve the equity of resource supply.
A Truly Cosmopolitan Philosopher: Images of Kant in Belo Horizonte
Authors: Kauark-Leite Patrícia 
Published: March 2023

AbstractIn this essay, I provide a reconstruction of the history of and surrounding the bust of Kant, together with its plaque, which jointly compose the monument created in honor of the sage of Königsberg at the Faculty of Philosophy and Human Sciences (FAFICH) of the Federal University of Minas Gerais (UFMG) in Belo Horizonte, Brazil. In so doing, I have the following aims: first, to examine the relationship between the monument and the ideas that guided the creation of the Faculty of Philosophy of Minas Gerais by one of its founders, Prof. Arthur Versiani Velloso; second, to highlight and register the authorship of this work by the plastic artist Frederico Bracher Júnior, as an important part of Kant’s international and indeed truly cosmopolitan iconography.
A symbolic approach to multiple Hurwitz zeta values at non-positive integers
Authors: Sadaoui Boualem , Jarad Fahd , Adjabi Yacine , Türkan Erkan Murat 
Published: March 2023

AbstractIn this article, we give another method to calculate the values of multiple Hurwitz zeta function at non-positive integers by means ofRaabe’s formula and theBernoullinumbers and we simplify these values by symbolic computation techniques.