bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mushroom Powder Ameliorates the Metabolic Syndromes by Maintaining Glucose and Lipid Homeostasis in High Sugar Diet-fed Mice
Authors: Chacrabati R , Khatun K , Kazal M K H , Moon R J , Bhattacharjya D K , Hossain M A , Goswami C 
Published: July 2023

Diets high in added sugar both directly and indirectly promote the development of metabolic diseases such as diabetes and obesity. The objective of this study was to evaluate the effects of mushroom powder (MP) in preventing the development of metabolic disorders caused by a high sugar diet. Swiss albino male mice were fed with normal diet (ND) or high sugar diet (HSD) in supplementation with or without mushroom powder. The results showed that supplementation of MP in high sugar diet effectively reduced the food intake and body weight of mice. Moreover, MP sustained glucose tolerance in HSD-fed mice and a significantly lower glucose level was observed in the MP supplemented group than that of the HSD group. Furthermore, kidney and heart weight were almost similar among the groups. However, MP supplementation significantly reduced the liver weight in comparison to that of HSD control group. The wet weights of white adipose tissue and brown adipose tissue were also lower in the MP supplemented groups in comparison to that of HSD group. In addition, supplementation of MP in the high sugar diet significantly decreased the level of total cholesterol, triacylglycerides, and LDL content. In conclusion, these results suggest that mushroom powder was effective in preventing the development of diabetes and obesity induced by a high sugar diet. As mushroom powder is an abundant source of nutrients, therefore, this powder can be an important dietary supplement for treating metabolic disorders instigated by a high-sugar diet.
J. of Sci. and Tech. Res. 4(1): 13-24, 2022
Exogenous Testosterone Causes Delayed Postnatal Testicular Development and Disrupts Spermatogenesis
Authors: Gofur M R , Khatun A , Sadi M S , Aktar S , Alam M E 
Published: July 2023

Proper postnatal development of testis is prerequisite for acquisition of full functional potential of testis. The initiation and maintenance of spermatogenesis depend on testosterone, and the production of mature sperm is highly reliant on androgen activity in the testis. The goal of the study was to investigate the effect of exogenous testosterone on testicular biometry and histomorphometry, and seminiferous epithelium in Black Bengal goat during the postnatal development. A total of 42 Black Bengal goats were divided into two categories: control and testosterone-treated; and each group again subdivided into seven groups (n=3) according to age, viz. group-I (at birth or day 0; d0), group-II (1 week of age), group-III (2 weeks), group-IV (1 month), group-V (2 months), group-VI (4 months), and group-VII (6 months). Goat kids of testosterone-treated group were injected with testosterone hormone @ 125 mg/kid (0.5 ml of Testanon™ 250 Injection, IM, 250 mg/ml, Nuvista Pharma Ltd., Bangladesh) IM weekly until the sample collection. The testicular development was slow up to 2 weeks of age, and after that, in control goats, a quick growth of the testicles was seen. In contrast, a slow trend of testicular development was continuous throughout the study period (postnatal 6 months) in testosterone-treated goats. A continuous and gradual developmental process of testis was observed in control goats. Seminiferous tubules were shown to have a marked increase in diameter at 4 months indicates initiation of spermatogenesis at this age, and completion of the first wave of spermatogenesis, i.e. establishment of spermatogenesis was observed by 6 months of age as confirmed by the presence of all types of cells of spermatogenic lineage in the seminiferous epithelium including spermatozoa were found attached to the Sertoli cells at their ad luminal border, and in the lumen of the seminiferous tubules. Continuous administration of exogenous testosterone exerted a negative effect on the postnatal developmental process of testis of Black Bengal goats. The postnatal developmental process of testis was very slow, and the proliferation of spermatogonia and lumenization of the seminiferous tubules, also known as seminiferous epithelium stratification, were not seen in testosterone-treated goats until they were 6 months old indicates delayed postnatal testicular development and disrupts spermatogenesis.
J. of Sci. and Tech. Res. 4(1): 25-36, 2022
Heat-Flux Effect on Fluid Flow and Convective Heat Transfer through a Rotating Curved Micro-Channel
Authors: Adhikari S C , Chanda R K , Akter R , Mondal R N 
Published: July 2023

The present paper investigates heat-flux effect and the dissemination of energy in a rotating bent square micro-channel (MC) subject to a temperature gradient between the vertical sidewalls. The flow structure prevailing the problem is solved by applying a highly accurate spectral-based numerical scheme. The flow controlling parameters are the Dean number (0<Dn≤5000) and the Taylor number (-500 ≤ Tr ≤ 2000) for curvature 0.01 and the Grashof number, Gr=1000. After applying the arc-length path continuation technique to obtain steady solution (SS) curves, two branches of SS consisting of 2- to 8-vortex solutions are prevailed for the non-rotating case while a single branch with a symmetric 2-vortex solution is for positive rotation of the channel. Unsteady flow (UF) properties are simulated by the time-average of the solutions, and the transitional behavior is well predicted by contemplating the power spectrum and phase spaces of the solutions. Results manifest that the UF experiences a consequence ‘steady-state àmulti-periodic àsteady-state’ for no rotation of the channel as Dn is increased. For the rotating case, on the other hand, the flow advances in the scenario ‘steady-state àmulti-periodic àsteady-state’ for negative rotation and only a steady-state solution for rotation in the positive direction. Streamlines and isotherms of SS and UF for various values of the flow-controlling parameters are obtained. Centrifugal force impacts the fluid mixer, which then assists to turn the flow into chaos and prompts to intensify the convective heat transfer (CHT).
J. of Sci. and Tech. Res. 4(1): 129-144, 2022
Pelatihan Pemanfaatan Portal Rumah Belajar dalam Pembelajaran Jarak Jauh bagi Guru Matematika dan IPA SMAN 5 Bengkulu Selatan
Authors: Handayani Dewi , Elvinawati Elvinawati , Rohiat Salastri , Alperi Muzanip 
Published: July 2023

Sekolah Menengah Atas Negeri (SMAN) 5 Bengkulu Selatan merupakan salah satu sekolah mitra Fakultas Keguruan dan Ilmu Pendidikan (FKIP) Universitas Bengkulu khususnya pada penyelenggaraan Program Magang Pengalaman Lapangan (PPL) bagi mahasiswa. Pembelajaran online membutuhkan model dan media pembelajaran yang mendukung. Media pembelajaran yang mendukung adalah media yang sesuai dengan kebutuhan pembelajaran online. Salah satu sumber media pembelajaran resmi, lengkap, valid, dan gratis adalah portal Rumah Belajar milik Kemdikbud. Portal pembelajaran yang menyediakan bahan belajar serta fasilitas komunikasi yang mendukung interaksi antar komunitas. Pada kegiatan pengabdian ini, tim mengadakan pelatihan pemanfaatan portal rumah belajar sebagai media pembelajaran bagi guru matematika dan IPA (Kimia, Biologi, Fisika) di SMAN 5 Bengkulu Selatan. Fitur-fitur yang ada dalam portal rumah belajar ini sangat lengkap diantaranya adalah sumber belajar, buku sekolah elektronik, bank soal, laboratorium maya, peta budaya dan kelas maya.
Türk Hukukunda Evlat Edinme Müessesesinin Tarihi Gelişimi
Authors: VATANSEVER ÖZTÜRK Müge 
Published: July 2023

Nesebi belli olsun olmasın başkasına ait bir çocuğu kendi çocuğu olarak kabul etme anlamındaki evlat edinme geçmişte ve günümüzde rastlanan sosyal ve hukuki bir olgudur. Aileyle çocuk arasında evlat edinme ilişkisinin kurulması, toplumlarda ortaya çıkan hukuk düzeninin yarattığı yapay bir soy bağı kurma yoludur.
İnsanların varoluşlarından beri ihtiyaç duydukları evlat edinme kurumunun kökeni, kendi hukuk tarihimiz açısından, İslamiyet öncesi Türk hukukunda bulunmaktadır. Uygur belgelerinden edinilen bilgilere göre, Eski Türklerdeki evlat edinme kuralları birçok yönden günümüzdeki kanun hükümleriyle benzerlik göstermektedir.
İslamiyet’in kabul edilmesiyle birlikte, İslam hukukunun onay vermediği evlat edinme kurumu, hukukumuzdan uzunca bir süreliğine çıkmıştır. Evlat edinme kurumu, 743 sayılı Türk Kanunu Medenisi ile birlikte ilk kez resmi olarak 1926 yılında hukukumuzda düzenlenmiştir. Kanunda evlat edinme, Uygur belgelerindeki gibi, sözleşme temeline dayandırılmıştır. Medeni Kanundaki evlat edinme ile ilgili hükümler 2001 tarihli ve 4721 Sayılı Kanunla gerek esasa ilişkin şartlarda gerek şekle ilişkin şartlarda oldukça geniş ve köklü değişiklikler yaparak yeniden düzenlenmiştir. İslamiyet öncesi Türklerde var olan evlat edinme kurumunun yüzyıllar sonra modern haliyle Cumhuriyet dönemi medeni kanunlarımızda yerini almış olması bir çeşit öze dönüş olarak nitelendirilmelidir.
Avaliação quantitativa da necessidade de encaminhamentos das Unidades de Saúde da Família e Unidades Básicas de Saúde na cidade de Cascavel-PR a partir da estratificação por distrito epidemiológico
Authors: Tressoldi Michelly , Fronza Dilson , Grando Alcy Bruno , Maffini Alana Ricieli 
Published: July 2023

No presente estudo, buscou-se avaliar a desproporção dos números de encaminhamentos nos anos de 2017 a 2020 dos profissionais dos diferentes distritos epidemiológicos que atuam nas Unidades Básicas de Saúde (UBS) em relação àqueles que trabalham nas Unidades de Saúde da Família (USF) do município de Cascavel-PR. Utilizou-se como base para o banco de dados os relatórios digitais/eletrônicos fornecidos pelo sistema de prontuários eletrônicos (IPM) do município de Cascavel dos anos de 2017 a 2020. A análise foi realizada de maneira transversal qualitativa e quantitativa dos encaminhamentos durante os anos do estudo, em maior destaque o acercamento quantitativo, por meio de análises estatísticas tabuladas, gráficos de barras e gráficos de pareto, utilizando a ferramenta Microsoft® Excel® 365.V16, para o teste de hipóteses da taxa da Poisson e intervalo de confiança, foi utilizado o Minitab® V.18.1, os testes foram aplicados com 95% de confiança. Resultados: Observou-se a existência de uma grande rotatividade de profissionais dentro da APS do municipio, fatoque dificulta a análise dos dados. Ainda assim, foi possivel observar que há resolutividade maior por parte das USFs quando comparadas as duas estratégias de saúde. Conclusão: levando em consideração os dados obtidos nesta pesquisa, pode-se concluir que USFs apresentam uma taxa de resolutividade maior que UBSs.
Klasifikasi Kemampuan Lahan Sebagai Arahan Pengelolaan Lahan Di Daerah Aliran Sungai Lepo-Lepo
Authors: Limda Nur Lina  , Laode Sabaruddin  , La Baco  
Published: July 2023

Land use that is not carried out or without considering the ability of the land can cause erosion and flooding risks. The aims of the research are (1) to determine land capability classes in the Lepo-Lepo watershed and (2) to determine land management guidelines at the class level in the Lepo-Lepo watershed as guidelines for sustainable development. The method used is to calculate land capability classes, laboratory analysis, and use geographic information systems. This research was carried out based on land unit maps and determining land capability classes, based on land capability class criteria. The results of the study showed that the land capability class in the Lepo-Lepo watershed was class II land capability with an area of 2,136.59 ha or 25.65%, land capability class III with an area of 1,282.42 ha or 15.39%, land capability class IV with an area of 1,181.15 ha or 14.18%, and Class VI land capability with an area of 497.84 ha or 38.80%. Based on the characteristics of the land, there is a threat of erosion marked with the letter e, with the management of terracing on steeply sloped land to reduce the amount of erosion, and the threat of excess water is marked with the letter w, with land management improving drainage, providing organic matter, planting vegetation and planting agroforestry system.
Keywords: Land Capability, Watershed, Management
Penggunaan lahan yang tidak dilakukan atau tanpa mempertimbangkan kemampuan lahan dapat menimbulkan resiko erosi dan banjir. Tujuan penelitian yaitu, (1) menetapkan kelas kemampuan lahan di DAS Lepo-Lepo dan (2) menetapkan arahan pengelolaan lahan pada tingkat kelas di DAS Lepo-Lepo sebagai pedoman pembangunan berkelanjutan. Metode yang digunakan yaitu menghitung kelas kamampuan lahan, analisis laboratorium, dan penggunaan sistem informasi geografis. Penelitian ini dilakukan berdasarkan peta satuan lahan dan penentuan kelas kemampuan lahan dilakukan berdasarkan kriteria kelas kemampuan lahan. Hasil kajian yang diperoleh Kelas kemampuan lahan di DAS Lepo-Lepo yaitu Kelas kemampuan lahan II dengan luas 2.136,59 ha atau 25,65 %, Kelas kemampuan lahan III dengan luas 1.282,42 atau ha 15,39 %, Kelas Kemapuan lahan IV dengan luas 1.181,15 ha atau 14,18 %, dan Kelas kemampuan lahan VI dengan luas 497,84 ha atau 38,80 %. Berdasarkan karakteristik lahan tersebut terdapat ancaman erosi yang ditandai dengan huruf e, dengan pengelolaan pembuatan teras pada tanah yang berlereng curam sehingga dapat mengurangi besarnya erosi, dan ancaman kelebihan air ditandai dengan huruf w, dengan pengelolaan lahan memperbaiki drainase, pemberian bahan organik, penanaman vegetasi dan penanaman sistem agroforestri.
Kata Kunci: Kemampuan Lahan, Daerah Aliran Sungai, Pengelolaan
Type 2 diabetes and in-hospital sudden cardiac arrest in ST-elevation myocardial infarction in the US
Authors: Mhaimeed Omar , Pillai Krishnadev , Dargham Soha , Al Suwaidi Jassim , Jneid Hani , Abi Khalil Charbel 
Published: July 2023

AimsWe aimed to assess the impact of diabetes on sudden cardiac arrest (SCA) in US patients hospitalized for ST-elevation myocardial infarction (STEMI).MethodsWe used the National Inpatient Sample (2005–2017) data to identify adult patients with STEMI. The primary outcome was in-hospital SCA. Secondary outcomes included in-hospital mortality, ventricular tachycardia (VT), ventricular fibrillation (VF), cardiogenic shock (CS), acute renal failure (ARF), and the revascularization strategy in SCA patients.ResultsSCA significantly increased from 4% in 2005 to 7.6% in 2018 in diabetes patients and from 3% in 2005 to 4.6% in 2018 in non-diabetes ones (p &lt; 0.001 for both). Further, diabetes was associated with an increased risk of SCA [aOR = 1.432 (1.336–1.707)]. In SCA patients with diabetes, the mean age (SD) decreased from 68 (13) to 66 (11) years old, and mortality decreased from 65.7% to 49.3% during the observation period (p &lt; 0.001). Compared to non-diabetes patients, those with T2DM had a higher adjusted risk of mortality, ARF, and CS [aOR = 1.72 (1.62–1.83), 1.52 (1.43–1.63), 1.25 (1.17–1.33); respectively] but not VF or VT. Those patients were more likely to undergo revascularization with CABG [aOR = 1.197 (1.065–1.345)] but less likely to undergo PCI [aOR = 0.708 (0.664–0.754)].ConclusionDiabetes is associated with an increased risk of sudden cardiac arrest in ST-elevation myocardial infarction. It is also associated with a higher mortality risk in SCA patients. However, the recent temporal mortality trend in SCA patients shows a steady decline, irrespective of diabetes.
Exploring the comparative cardiovascular death benefits of sodium–glucose cotransporter 2 inhibitors in type 2 diabetes: a frequentist and Bayesian network meta-analysis-based scoring
Authors: Ghosal Samit , Sinha Binayak 
Published: July 2023

Background and aimsCardiovascular death (CV death) is the most objective component of the primary or secondary endpoint in cardiovascular outcome trials (CVOTs) conducted with sodium–glucose cotransporter 2 inhibitors (SGLT-2is). CV death is often incorporated into primary composite outcomes. It is combined with major adverse cardiovascular events (MACEs) in trials with atherosclerotic cardiovascular disease (ASCVD) at baseline and with hospitalization due to heart failure (hHF) in trials with heart failure at baseline. Unlike the primary composites, CV death reduction by itself demonstrated significant variations among the CVOTs with SGLT-2is. Moreover, the impact of the individual agents within the SGLT-2i group on the reduction in CV death has not been explored objectively. This network meta-analysis was undertaken to construct a hierarchy based on indirect pairwise comparisons and rankings among the individual agents within SGLT-2is.MethodsA Cochrane library-based web search yielded 13 randomized controlled trials for analysis. Stata/BE 17.0 and RStudio 2022.07.1 Build 554 software were used to conduct a frequentist and Bayesian network meta-analysis. The effect size was assessed based on the risk ratio (RR). Ranking of the individual agents was performed with a frequentist approach (P-score and a multidimensional scaling [MDS] rank system) and a Bayesian ranking (surface under the cumulative ranking [SUCRA]).ResultsRegarding the overall data, SGLT-2is reduced the CV death risk by 12% (RR: 0.88, 95% CI 0.80–0.96). All three scoring methods resulted in empagliflozin scoring the highest. There was a 15% RR reduction in CV death (95% CI 0.71–1.02) in the ASCVD and multiple cardiovascular risk factor (MRF) groups and an 11% RR reduction in the HF group, with empagliflozin ranking the highest in the former group and dapagliflozin in the latter.ConclusionsEmpagliflozin ranked the highest compared to the other SGLT-2is in the overall population and the trials including type 2 diabetes (T2D) patients with ASCVD or MRF at baseline, while dapagliflozin ranked the highest in the trials of patients with HF at baseline.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022381556, identifier CRD42022381556.
Effect of hyaluronic acid-enriched transfer medium on frozen–thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study
Authors: Yan Qiang , Zhao Mei , Hao Fan , Zhao Ruru , Teng Xiaoming , He Bin , Zhu Chong , Chen Zhiqin , Li Kunming 
Published: July 2023

IntroductionMany patients who undergo assisted reproductive technology (ART) suffer from recurrent implantation failure (RIF). The addition of hyaluronic acid (HA) to the transfer medium is one of several methods to improve pregnancy outcomes. We investigated whether HA could improve the live birth and clinical pregnancy rates of RIF patients.MethodsThis study included 248 RIF patients, who were divided into two groups: the control (CTL) group (n=137), which received transfer medium without HA, and the HA group (n=111), which received transfer medium with HA. The two groups were compared according to the ART outcome.ResultsThe primary outcomes were the clinical pregnancy and live birth rates. Secondary outcomes include a positive urine pregnancy test, the implantation, ongoing pregnancy, multiple pregnancy, clinical miscarriage, and ectopic pregnancy rates, foetal or congenital defects, obstetric complications, infant birth weight and any related adverse events. Regarding the primary outcomes, the clinical pregnancy rate was significantly higher in the HA group than in the control group, and there was no significant difference in the live birth rate (LBR) between the HA and control groups. Regarding the secondary outcomes, the implantation, multiple pregnancy and ectopic pregnancy rates were similar between the two groups.DiscussionOur findings supported the conclusion that HA can improve the clinical pregnancy rate of patients with RIF undergoing FET cycles, but the live birth rate was not significantly improved with the addition of HA to the traditional transfer medium.
Fusion model with attention mechanism for carbon-neutral sports competitions
Authors: Zhang Jun , Zhang Xuan 
Published: July 2023

IntroductionIn sports competitions, using energy-saving and emission-reduction measures is an important means to achieve the carbon neutrality goal.MethodsIn this paper, we propose an attention mechanism-based convolutional neural network (CNN) combined with the gated recurrent unit (GRU) for carbon neutral energy saving and emission reduction prediction model in sports competitions, CNN is a feedforward neural network whose input is a two-dimensional matrix. The main feature of CNN is that it can handle multi-channel input data, and the use of GRU can make the model structure simple and largely reduce The use of GRU can make the model structure simple, which largely reduces the hardware computational power and time cost and also better solves the long dependency problem in RNN networks. CNN-GRU extracts the data for features and then optimized by the attention mechanism.ResultsThe model collects real-time carbon emissions data from sports events, including game times, lighting usage, air conditioning emissions and other carbon emissions data, and uses deep learning algorithms to predict and compare carbon emissions from sports competition.DiscussionIn identifying energy saving and emission reduction measures conducive to the realization of the goal of carbon neutral sports events, the model has a certain reference value for realizing energy saving and emission reduction in sports competitions under carbon neutrality goals.
Identification and validation of immune-associated NETosis subtypes and biomarkers in anti-neutrophil cytoplasmic antibody associated glomerulonephritis
Authors: Tao Mi , He Yiqing , Li Lijuan , Li Yuyan , Liao Wenwen , Nie Haihang , Gao Ping 
Published: July 2023

BackgroundNETosis is a new form of cell death, marked by DNA chromatin release from dead neutrophils. While it aids in microbe defense, it may worsen inflammation in autoimmune diseases, causing tissue harm. The impact of NETosis on Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis (ANCA-GN) remains unexplored and requires investigation.MethodsFirst, a weighted gene co-expression network analysis (WGCNA) was conducted to uncover differential expression of neutrophil extranuclear trap-associated genes (DE-NETs) in ANCA-GN. The NETosisScore model was established through the single sample gene set enrichment analysis (ssGSEA), which categorized all patients into high-risk and low-risk groups. The accuracy of model was assessed by ROC curve. The biological function of various subgroups was explored through Gene Set Variation Analysis (GSVA), while the abundance of immune cell infiltration was measured with CIBERSORT. Furthermore, the key NETosis-related genes (NRGs) were identified using three machine learning algorithms, and their relationship with renal function was analyzed through the NephroseqV5 database. Through the application of qPCR and immunohistochemical staining techniques, the mRNA and protein expression levels of NRGs were determined in patients with ANCA-GN and control.ResultsA NETosisScore model was developed from 18 DE-NETs using the ssGSEA algorithm. The model’s ability to predict ANCA-GN patients with a ROC AUC of 0.921. The high-risk group in ANCA-GN showed enrichment of immune-related pathways and greater infiltration of immune cells, as revealed by KEGG enrichment analysis and CIBERSORT. Using three machine learning algorithms, we identified six NRGs. Significant positive correlations were found between NRGs and CCR, macrophages, T-cell co-inhibition, and TIL. Further KEGG analysis revealed that the functions of NRGs may be closely related to the toll-like receptor signaling pathway. The levels of NRGs increased as kidney function declined and were positively correlated with Scr (serum creatinine) and negatively correlated with GFR (glomerular filtration rate), qPCR analysis showed increased expression of most NRGs in ANCA-GN patients. Furthermore, immunohistochemical staining confirmed higher expression of all NRGs in ANCA-GN patients.ConclusionNETosisScore model accurately predicts high-risk patients in ANCA-GN with enriched immune pathways, 6 NRGs identified as potential biomarkers.