bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical and machine learning approaches to study weather-disease-mustard yield relationship under varying environmental conditions
Authors: Singh Manjari , Nain Ajeet Singh 
Published: January 2023

Abstract

The sowing window of mustard crop under Indian conditions, often varies from place to place and from year to year, creating a diverse set of environmental conditions available for crop growth and development. The present study examines the use of statistical and machine learning approaches for mustard yield prediction at eight sowing dates, using long-term (2006–2021) weather and disease data collected from the experimental fields of GB Pant University of Agriculture & Technology, Pantnagar, India. Descriptive statistics suggest that there is a drastic reduction in mustard yield when sowing is delayed after October 15. Cross comparison of models suggested that ANN followed by LASSO can be used for mustard yield prediction satisfactorily at most of the sowing dates. Among different modelling approaches, ANN approach resulted in a higher coefficient of determination (R2 ≈ 1), with a lower normalised root mean square error (nRMSE) during calibration (ranging between 0.05 and 2.08), as well as validation (ranging between 0.02 and 4.57) for different sowing dates, over other approaches. The Pearson correlation coefficients (r) were also determined for the observed and predicted yield. These values also showed ANN as the best performing model with correlation values ranging from 0.63 to 1.00, followed by LASSO (0.47–0.92), ENET (0.46–0.92), and Ridge (0.38–0.91). Small values ofrcorrespond to the late sowing dates DOS 6 and onwards. Machine learning approach ANN outperformed the shrinkage regression methods for most of the sowing dates with its lower error values and higher correlation coefficient values. From the above study it was concluded that machine learning approaches using weather indices and disease severity as the predictor can be effectively used for precise yield prediction of mustard crop under different environmental conditions of north India.
Integrative analyses of genes and miRNAs associated with age-related sarcopenia
Authors: Lee Sangyeob , Seo Sung Hyo , Yoo Jun-Il 
Published: January 2023

Abstract
Identifying genome-wide transcription expression patterns is important to confirm general gene function in sarcopenia patients. The purpose of this study was to find differentially expressed miRNAs (DE-miRNAs) in the muscle samples of older people. In addition, we researched to find new miRNA-mRNA regulatory network for treating sarcopenia. Microarray datasets of Gene Expression Series (GSE) 8479 and GSE1428 were obtained for the vastus lateralis muscles of young and older male subjects. Dataset GSE23527 contained microRNA arrays of 12 young muscle samples and 12 older muscle samples. In the GSE8479 and GSE1428 datasets, a total of 81 DEGs were discovered, including 4 upregulated genes and 77 downregulated genes. The top 12 clusters and their representative enriched terms were identified using Metascape. A total of 79 nodes and 186 edges were predicted in the PPI network. 1 upregulated DE-miRNA (hsa-miR-450a-5p) and 6 downregulated DE-miRNAs (hsa-miR-127-3p, hsa-miR-24-2-5p, hsa-miR-378a-5p, hsa-miR-532-5p, hsa-miR-487b-5p, and has-miR-487b-3p) were selected in the miRBase database. The MiRWalk online database was utilized for exploring 8017 genes that were selected as genes regulated by DE-miRNAs and six of them overlapped with hub genes. COX7A1 and NDUFB5 showed significantly low expression in sarcopenia patients compared to the controls. The bioinformatics analysis showed that two target genes (COX7A1 and NDUFB5) were potentially downregulated in sarcopenia patients. Several miRNAs (hsa-miR-378a-5p, hsa-miR-532-5p, hsa-miR-127-3p, and hsa-miR-24-2-5p) were identified as regulating the target genes. These results suggest that controlling the identified miRNAs could be a prospective strategy for treating sarcopenia by regulating the mRNA-miRNA network. Level of Evidence: Level I
Cognition	Enhancement Strategies by Ion	Channel Modulation of Neurotransmission
Authors: Eid, Jr. Clark N. , Rose Gregory M. 
Published: January 2023

Abstract:
Relatively few effective therapies exist for the multitude of disorders that comprise dementia, a clinical syndrome manifested by impairments in cognition. language and memory. Treatment of Alzheimer's disease (AD), the most common cause or dementia, is a primary goal of research in cognitive enhancement. However, despite intense research, effective pharmacological interventions remain to be developed. The preponderance of pharmacological strategies which are being pursued in AD research attempt to relieve cognitive and memory deficits which are attributed to cholinergic dysfunction. This paper briefly reviews the status of other efforts that have in common the potential to enhance the use-dependent activity of multiple neurotransmitters system through the modulation of gated ion channels. Discussed are recent advances in the areas of: 1) y-aminobutyric acid subtype A receptor/benzodiazepine (GABAA/BZ) inverse agonists; 2) nicotinic acetylcholine receptor (nAChR) agonists; 3) serotonin subtype 3 receptor (5-HT3R) antagonists; and 4) potassium (K+) M-channel inhibitors.
Management of Impacted Mandibular Second Molar: A Case Report
Authors: Halim Himawan , Halim Ivan A. 
Published: January 2023

Introduction:
In rare cases, impacted second molars may create additional problems for orthodontic treatment. Both parents and the orthodontist should be aware of this problem early to prevent further complications. Good teamwork between the orthodontist and oral maxillofacial surgeon is needed in handling these cases, especially if it involves removing the impacted second molar. The right time to treat an impacted second molar is between the age of 11 to 14 years old. An impacted second molar can lead to a lack of arch length in the patient.

Objective:
The case report described the management of a female patient with a treated left-and-right impacted second molar in the mandible. The chief complaint of the patient was a protrusive mouth and having two impacted second molars, as told by her general dentist.

Case Report:
A 15-years-old female patient with Class I molar relationship, bilateral second molar impaction, and bimaxillary protrusion visited the clinic for orthodontic treatment. Extraction of four first premolar and mandibular second molar was completed. Both mandibular third molars were moved anteriorly to help close the space.

Conclusion:
Good cooperation from various disciplines and treatment planning to resolve the case can produce excellent and ideal results.
A Methodology to Identify the Hinterland for Freight Ports by Transportation Cost Functions
Authors: Gattuso Domenico , Cassone Gian Carla , Pellicanò Domenica Savia 
Published: January 2023

Introduction:
The competitiveness of a port depends on hinterland characteristics, among other factors. In particular, hinterland accessibility and efficient inland logistics are key factors in ensuring the speed of goods flows. The port systems have to be configured as an efficient and logistically effective interface between oceanic maritime trade and inland trade.
The paper has been elaborated starting from research carried out in the European ISTEN project (Integrated and Sustainable Transport in the Efficient Network), aiming to improve the intermodal connections among the ports of the Adriatic-Ionian area and the ports and their hinterlands.

Objective:
The objective of the work is to propose an original approach for identifying the port hinterland based on the evaluation of transport times and costs in the whole supply chain (from the origin in the foreland zone to a final destination in the hinterland).

Methods:
The analyses have been carried out by considering separately the transport time and monetary cost components and generalized transport cost. The methodology involves wide research of data and careful analysis of the port hinterland connectivity. An analytical application is proposed in order to identify and compare the potential hinterlands of two Italian ports, Gioia Tauro and Genoa.

Results:
The results of the proposed analyses show that the geographical distribution of the port hinterlands changes significantly in relation to the reference drivers in terms of monetary cost and time along the intermodal international paths; this has led to further analyses considering the transport generalized cost which has integrated into travel time and monetary cost.

Conclusion:
The aim of the proposed approach is to overcome the limits of the methodologies of the sector based on geographical characteristics that focus attention only on market aspects considering marginally the transport component. The methodology is transferable to other contexts and other types of freight interchange nodes by adapting the cost functions.
Spatial Analysis of the Contribution of Parking Service Facilities to Traffic Crashes along Limited-access Roadways
Authors: Alkhatni Fathi , Ishak Siti Zaharah , Hashim Wardati Binti , Borhan Muhamad Nazri , Zahran Elsaid Mamdouh Mahmoud 
Published: January 2023

Background and Objective:Parking service facilities (PSFs) are integral components of road networks and are typically designated to offer road users, stakeholders, and external entities various services and opportunities. However, the current literature manifests contradictions among studies regarding the contribution of PSFs to crashes in the mainline traffic stream. This study aims to assess the contribution of PSFs to traffic crashes on limited-access expressways using hotspot analysis of traffic crashes in GIS.Methods:Planar Getis-Ord Gi* and network KDE were used to detect crash hotspots along a study road based on five criteria: crash frequency of all vehicle types, frequency of all vehicles involved in crashes, frequency of heavy vehicles involved in crashes, injury severity index and iRAP star rating.Results:The study identified and ranked the safety hazard of PSFs along the study roadviathe interference and risk level of crash hotspots with influential segments of PSFs. Getis-Ord Gi* analysis showed that almost 65% of PSFs along the study road were potentially high-risk facilities, with their influential segments interfering with crash hotspots based on the five hotspot analysis criteria. On the other hand, network KDE identified that almost 100% of PSFs along the study road were potentially high-risk facilities of either serious, significant or moderate risk levels based on the same hotspot analysis criteria.Conclusion:The two spatial analyses indicated that crashes in proximity to PSFs may increase when the number of lanes of their influential road segments increases and traffic flow is interrupted by other road facilities. They also indicated that crash frequency and severity increase in the proximity to PSFs with high speed and high traffic volume. Furthermore, the two analyses indicated that heavy vehicle crashes are more likely to increase in proximity to PSFs in rural areas.
Design and Analysis of a Radiation Resistant 12T SRAM Cell for Aerospace
Applications
Authors: Bikki Pavankumar , Bharathi M.L.V.V. , Jyothi K. Madhavi 
Published: January 2023

Introduction:
Advanced low-power designs have been scaled down to the device parameters
that increase single-event multi-node upset in memory elements. This degradation of the stability
of the memory elements in aerospace applications is due to the high radiation environment and
rapid temperature changes.

Method:
Hence, this paper presents a comprehensive treatment model for hardened storage elements
with a soft error resulting in multi-node upset. A novel 12T SRAM memory cell configuration has
been proposed, analysed, and simulated using Cadence Virtuoso gpdk 45 nm CMOS technology.

Result:
The proposed design counteracts the positive feedback induced due to the charged ion
strike, as in past technical literature. The radiation environment has been realized with double exponential
current sources, and temperature analysis has been carried out under parametric analysis.

Conclusion:
The novel 12T achieves good stability and remains resilient to bit-flip due to ion
strikes for a wider range of voltage when the temperature varies from -50oC to 200oC. Moreover, the
proposed structure features a lower susceptibility to single event upset, less write and read time, and
reduced area compared to the reported RSP 14T.
Using Location Intelligence to Evaluate the COVID-19 Vaccination Campaign in the United States: Spatiotemporal Big Data Analysis
Authors: Li Qingfeng , Peng James Cheng , Mohan Diwakar , Lake Brennan , Euler Alex Ruiz , Weir Brian , Kan Lena , Yang Cui , Labrique Alain 
Published: January 2023

Background
Highly effective COVID-19 vaccines are available and free of charge in the United States. With adequate coverage, their use may help return life back to normal and reduce COVID-19–related hospitalization and death. Many barriers to widespread inoculation have prevented herd immunity, including vaccine hesitancy, lack of vaccine knowledge, and misinformation. The Ad Council and COVID Collaborative have been conducting one of the largest nationwide targeted campaigns (“It’s Up to You”) to communicate vaccine information and encourage timely vaccination across the United States. More than 300 major brands, digital and print media companies, and community-based organizations support the campaigns to reach distinct audiences.

Objective
The goal of this study was to use aggregated mobility data to assess the effectiveness of the campaign on COVID-19 vaccine uptake.

Methods
Campaign exposure data were collected from the Cuebiq advertising impact measurement platform consisting of about 17 million opted-in and deidentified mobile devices across the country. A Bayesian spatiotemporal hierarchical model was developed to assess campaign effectiveness through estimating the association between county-level campaign exposure and vaccination rates reported by the Centers for Disease Control and Prevention. To minimize potential bias in exposure to the campaign, the model included several control variables (eg, age, race or ethnicity, income, and political affiliation). We also incorporated conditional autoregressive residual models to account for apparent spatiotemporal autocorrelation.

Results
The data set covers a panel of 3104 counties from 48 states and the District of Columbia during a period of 22 weeks (March 29 to August 29, 2021). Officially launched in February 2021, the campaign reached about 3% of the anonymous devices on the Cuebiq platform by the end of March, which was the start of the study period. That exposure rate gradually declined to slightly above 1% in August 2021, effectively ending the study period. Results from the Bayesian hierarchical model indicate a statistically significant positive association between campaign exposure and vaccine uptake at the county level. A campaign that reaches everyone would boost the vaccination rate by 2.2% (95% uncertainty interval: 2.0%-2.4%) on a weekly basis, compared to the baseline case of no campaign.

Conclusions
The “It’s Up to You” campaign is effective in promoting COVID-19 vaccine uptake, suggesting that a nationwide targeted mass media campaign with multisectoral collaborations could be an impactful health communication strategy to improve progress against this and future pandemics. Methodologically, the results also show that location intelligence and mobile phone–based monitoring platforms can be effective in measuring impact of large-scale digital campaigns in near real time.
Time Spent on Instagram and Body Image, Self-esteem, and Physical Comparison Among Young Adults in Spain: Observational Study
Authors: Alfonso-Fuertes Isabel , Alvarez-Mon Miguel Angel , Sanchez del Hoyo Rafael , Ortega Miguel A , Alvarez-Mon Melchor , Molina-Ruiz Rosa M 
Published: January 2023

Background
Instagram is a social media platform based on photos and videos that encourages interaction and comparison between users. Its growing popularity, especially among young people, has generated interest in the impact its use can have on users´ mental health, specifically on their self-esteem and degree of satisfaction with their own body image.

Objective
We aimed to analyze the relationships between the use of Instagram, both the hours of daily use and the type of content viewed, and self-esteem, tendency to make physical comparisons, and satisfaction with body image.

Methods
In this cross-sectional study, we recruited 585 participants aged between 18 years and 40 years. Individuals who were interested in participating but had a personal history of eating disorders or had previously been diagnosed with a psychiatric disorder were excluded. The assessment tools consisted of (1) a questionnaire that collected sociodemographic data and Instagram use variables and was created by the research team specifically for this study; (2) the self-esteem scale by Rosenberg; (3) Physical Appearance Comparison Scale-Revised (PACS-R); and (4) Body Shape Questionnaire (BSQ). The recruitment and evaluation processes were carried out in January 2021.

Results
Of the participants, 234 (234/585, 40%) used Instagram less than 1 hour a day, 303 (303/585, 51.8%) used Instagram between 1 hour and 3 hours a day, and 48 participants (48/585, 8.2%) used it more than 3 hours per day. We found statistically significant differences (P<.05) between the 3 groups in the scores obtained on the self-esteem test by Rosenberg, PACS-R, and BSQ. Participants who spent more time on Instagram had higher levels of body dissatisfaction, greater comparisons of physical appearance, and lower self-esteem. Moreover, we analyzed the relationship between the score obtained on the different scales and the types of content viewed, with no differences between those who mainly viewed professional content and those who primarily consumed fashion and beauty or sport and nutrition content.

Conclusions
The results of this study indicate that the use of Instagram is associated with poorer body image satisfaction and self-esteem, mediated by the tendency to compare physical appearance in relation to the daily duration of Instagram use.
A new species of Eriogonum (Polygonaceae) from the Cape region of the Baja California Peninsula, Mexico
Authors: León-de la Luz José Luis , Rebman Jon Paul , Medel-Narváez Alfonso 
Published: January 2023

We describe and illustrate Eriogonum calaverense, a new species of Polygonaceae from the southern tip of the Baja California peninsula, Mexico. It is known only from the granitic rock crevices of Cerro de la Calavera, and others in the vicinity, in the southern Cape region mountains. This species is characterized by its suffrutescent habit, as well as by its densely tomentose indumentum, which on its leaves is manifested by different color shades on the upper and lower sides. We present a detailed botanical description, illustrations, and photographs of this new taxon. Since this species seems to be linked to special edaphic conditions, we provide some locations where it might also be found with additional field exploration. The exact taxonomic placement of this new taxon within the genus Eriogonum is still in question and future cytogenetic and molecular data might help to address this problem.
The effectiveness of topical Arnebia euchroma Oil in the treatment of Pressure Ulcer: A Case Report
Authors: Mohhamadi Kenari Hoorieh , Erabi Sakineh , Ghobadi Ali 
Published: January 2023

Decreased tissue blood flow causes pressure ulcers due to prolonged pressure on the area, which becomes problematic for immobile individuals. The medical community has often been involved in curing such a problem in individuals with disabilities and immobility. To alleviate this problem, therefore, plenty of investigations are always seeking novel methods. Furthermore, herbal plants are increasingly used owing to the accepted status of plant-derived drugs in recent years. Our female case aged 52 years that was referred to the wound clinic complaining sensory and motor weakness of the upper extremity and sudden paralysis of the lower extremity as of 1 year ago, which was diagnosed as myelitis. She complained of two wounds on both sides of the right and left buttocks with a size of 9 × 5 and another 6 × 4.5 cm from 3 months ago, and a wound with a size of 5 × 4.5 in the sacral area (sacrum) from 20 days prior to the admission. There was tissue necrosis without muscle engagement, osteomyelitis, or tunneling; besides, nasty odors and sludge were absent accounted for in class 3 in the group of wounds. She received starting therapy using Arnebia euchroma oil. As of the 2nd week onward, she was treated very successfully, and the complete wound healing occurred in 8 weeks. The use of A. euchroma for wound healing and reducing infection and inflammation can greatly contribute to the cure of pressure ulcers and can be properly suggested in healing these ulcers.
Penentuan Prioritas Penggantian Uang Bahan Bakar Minyak Dengan Metode Naive Bayes
Authors: Anandra Dyah Ayu , Fathonah Rd. Nuraini Siti 
Published: January 2023

Dalam suatu instansi untuk pencatatan bahan bakar minyak dan penentuan prioritas supir yang akan diganti uangnya terlebih dahulu sangat krusial. Permasalahan yang dihadapi oleh PT.XYZ adalah kesulitan dalam mengklasifikasikan supir yang harus mendapat penggantian uang terlebih dahulu. Saat ini untuk pengklasifikasian yang dilakukan hanya mengandalkan pengolahan data dan pengurutan dengan Microsoft Excel. Untuk menghindari hal yang tidak diinginkan seperti Human Error ataupun redudansi maka sistem ini dibangun. Dengan metode naïve bayes membantu agar dapat menentukan prioritas supir yang akan mendapat uang ganti bahan bakar minyak (BBM). Metode pengklasifikasi Naive Bayes adalah pengklasifikasi statistik yang dapat memprediksi probabilitas keanggotaan kelas dari kelas tertentu berdasarkan perhitungan probabilitas. Berdasarkan hasil akhir yang telah dilakukan dengan mengambil beberapa semple dari beberapa data training maka akurasi untuk menentukan prioritas supir penggantian bahan bakar minyak (BBM) adalah 100%. Maka dapat disimpulkan bahwa metode naïve bayes keakuratannya sangat tinggi untuk menentukan prioritas penggantian uang bahan bakar minyak (BBM) untuk supir.
MOEDA ELETRÔNICA DO BANCO CENTRAL
Authors: Oliveira Victor Augusto de Almeida , Bertolai Jefferson Donizeti Pereira 
Published: January 2023

O assunto criptomoedas tem recebido bastante atenção por parte da mídia, de organismos internacionais, de bancos centrais e do meio acadêmico. Em particular, tem sido discutido se é de interesse dos bancos centrais a emissão de uma criptomoeda ou de uma moeda digital soberana. A diferença entre essas duas formas de acesso ao balanço do banco central é a forma de transmissão de unidades monetárias entre os usuários. Enquanto a criptomoeda soberana possui transmissão por meio de um sistema descentralizado, a moeda digital soberana é transmitida em um sistema centralizado. Este trabalho busca mostrar que o principal ponto que distingue os sistemas centralizado e descentralizado é a necessidade de monitoramento dos intermediários. Ademais, conclui-se que o sistema permissionado pode ser considerado centralizado pela necessidade de monitoramento dos agentes. Por fim, este trabalho propõe-se a discorrer sobre outras questões que envolvem a emissão de uma moeda eletrônica do banco central, em particular sobre os benefícios que podem advir dessa inovação e sobre os efeitos que pode causar ao setor bancário.