bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifocal/multicentric breast cancer: Does each focus matter?
Authors: Tong Ying , Sun Feixiang , Zhang Chuanpeng , Yang Susu , Yu Ziyi , Zhao Yi 
Published: February 2023

AbstractBackgroundMultifocal (MF) and multicentric (MC) breast cancer cases have been increasingly diagnosed owing to the extensive use of improved preoperative breast imaging. The current tumor‐node‐metastasis staging system uses the dimension of the largest tumor and recommends reporting the pathological features of the largest tumor in MF/MC breast cancers.AimThis study aimed to explore whether the largest or aggregate dimensions of MF and MC breast cancers can better predict tumor behavior. We also attempted to study the histological and biological heterogeneities of separate foci in MF and MC breast cancers to determine whether it was necessary to examine each lesion.MethodsWe retrospectively analyzed 121 patients with MF/MC (103 with MF and 18 with MC) breast cancers and 484 patients with unifocal breast cancer who were treated at the First Affiliated Hospital of Nanjing Medical University. Two methods were used to record the T stage (using the dimensions of the largest lesion and aggregate dimensions of all lesions). The histological grade, immunohistochemical parameters, and molecular subtypes of the largest lesion and other lesions in MF/MC breast cancers were studied to assess intertumoral heterogeneity.ResultsThe use of aggregate dimensions upstaged 63 patients with MF/MC breast cancers to a more advanced stage and removed the independent effect of cancer multiplicity on lymph node positivity compared with the use of the largest dimension. Mismatches were found in the pathological type (9.9%), histological grade (4.1%), and molecular subtype (8.3%) among different foci.ConclusionThe tendency of MF/MC breast tumors to metastasize may be related to tumor load, which can be better predicted by the aggregate dimensions of all foci. The use of the current staging systems may require further evaluation and modification. Intertumoral heterogeneity indicates the necessity for pathological and immunohistochemical assessments of each lesion in patients with MF/MC breast cancers.
Ameta‐analysisof the effects ofafter‐schoolprogrammes among youth with marginalized identities
Authors: Christensen Kirsten M. , Kremer Kristen P. , Poon Cyanea Y. S. , Rhodes Jean E. 
Published: February 2023

AbstractAfter‐school programmes (ASPs) often provide youth with a safer alternative to unstructured time while providing a context for building skills and forging positive relationships with programme staff and peers. ASPs may be particularly effective for youth with marginalized identities, including youth of colour and youth from low‐income backgrounds. Despite this promise, few rigorous evaluations of ASPs have been conducted and even fewer meta‐analyses have investigated the effects of ASPs among youth with marginalized identities. Using a multi‐level meta‐analysis of 615 effect sizes across 56 studies (overalln = 128,538), the current study examined the overall effects of ASPs on internalizing, externalizing, school‐related, social functioning, and self‐perception/identity outcomes among kindergarten through 12th grade youth with marginalized identities. Results indicated ASPs to have a small, yet significant positive overall effect on youth outcomes (g = 0.2049,p = .001, 95% CI = 0.08–0.33). Moderator analyses revealed significant differences in effects based on outcome source and outcome measure type. Given the ubiquity of ASPs and the challenges that youth experiencing marginalization face, this study uniquely adds to the existing literature and outlines important implications and recommendations for research, policy, and practice.
An EEG‐based neuro‐recommendation system for improving consumer purchase experience
Authors: Panda Debadrita , Chakladar Debashis Das , Rana Sudhir , Parayitam Satyanarayana 
Published: February 2023

AbstractThe aperture between the marketing domain and the electroencephalography (EEG)‐based brain–computer interface (BCI) has been achieved with the inception of neuromarketing. This domain helps access the hidden information of the preferences and tastes of the consumers who intend to purchase. Research scholars have experimented with this emerging area in multiple aspects like designing pricing, promotions, predicting purchase‐related activities, new product development, and so on. In this study, we have proposed an innovative use of neuromarketing to build a recommendation system. This recommendation system can potentially suggest suitable products to the consumer based on the past purchase behavior. This proposal carries huge potential in converting visitors to shoppers, increasing average order value, increasing the number of items per order, designing personalized promotions, and so on. The commonality of activated brain signals has been used to build this recommendation system. This neuromarketing‐based recommendation system carries the advantage over the traditional recommendation system as this system suggests products based on the actual real‐time state of the brain during the purchase. This system successfully initiated the starting point of building a neuromarketing‐based recommendation system.
Environmentally‐Friendly Pesticidal Activities ofCallicarpaandKaromiaEssential Oils from Vietnam and Their Microemulsions
Authors: Hung Nguyen Huy , Quan Pham Minh , Dai Do Ngoc , Satyal Prabodh , Huong Le Thi , Giang Le Duc , Hung Le Thanh , Setzer William N. 
Published: February 2023

AbstractThere is an ongoing interest to identify alternative pesticidal agents to avoid the chronic problems associated with synthetic pesticides. Essential oils have shown promise as botanical pest control agents. In the present study, the essential oils of four members of the Lamiaceae (Callicarpa candicans,C. erioclona,C. macrophylla, andKaromia fragrans; Vietnamese names: Nàng nàng, Tu châu lông mem, Tu châu lá to and Cà diện, respectively), obtained from wild populations in Vietnam, have been obtained by hydrodistillation and analyzed by gas chromatography‐mass spectrometry. The essential oils were formulated into microemulsions and the essential oils and their microemulsions were screened for mosquito larvicidal activity againstAedes aegypti,Aedes albopictus,Culex quinquefasciatus, and for molluscicidal activity againstPomacea canaliculata. Atractylone and (E)‐caryophyllene dominated the volatiles ofC. candicans(CCEO) andC. erioclona(CEEO), while the major component inC. macrophylla(CMEO) andK. fragrans(KFEO) was (E)‐caryophyllene. The essential oils and microemulsions of bothC. candicansandC. erioclonaexhibited excellent larvicidal activity against all three mosquito species (Ae. aegypti,Ae. albopictus, andCx. quinquefasciatus) with LC50values <10 μg/mL. Additionally, the larvicidal activity of the microemulsions were significantly improved compared with their free essential oils, especially forC. candicansandC. erioclona. All four essential oils and their microemulsions showed excellent molluscicidal activity with LC50<10 μg/mL. In most cases, the essential oils and microemulsions showed greater pesticidal activity against target organisms than the non‐target freshwater fish,Oreochromis niloticus. Thein silicostudies on physicochemical and ADMET properties of the major components in the studied essential oils were also investigated and most of the compounds possessed a favorable ADMET profile. Computational modeling studies of the studied compounds demonstrated a favorable binding interaction with the mosquito odorant‐binding protein target and support atractylone, β‐selinene, and caryophyllene oxide as potential inhibitors. Based on the observed pesticidal activities of the essential oils and their microemulsions, theCallicarpaspecies andK. fragransshould be considered for potential cultivation and further exploration as botanical pesticidal agents.
COVID‐19: A trigger of autoimmune diseases
Authors: Zebardast Arghavan , Hasanzadeh Ali , Ebrahimian Shiadeh Seyedeh Arefeh , Tourani Mehdi , Yahyapour Yousef 
Published: February 2023

AbstractThe SARS‐coronavirus‐2 (SARS‐CoV‐2) that causes coronavirus disease 2019 (COVID‐19), has spread worldwide and caused a global health emergency. SARS‐CoV‐2 is a coronaviridae virus that infects target cells by interacting with the plasma membrane‐expressed angiotensin‐converting enzyme 2 (ACE2) via the S1 component of the S protein. Effective host immune response to SARS‐CoV‐2 infection, which includes both innate and adaptive immunity, is critical for virus management and elimination. The intensity and outcome of COVID‐19 may be related to an overabundance of pro‐inflammatory cytokines, which results in a “cytokine storm” and acute respiratory distress syndrome. After SARS‐CoV‐2 infection, the immune system's hyperactivity and production of autoantibodies may result in autoimmune diseases such as autoimmune hemolytic anemia, autoimmune thrombocytopenia, Guillain‐Barré syndrome, vasculitis, multiple sclerosis, pro‐thrombotic state, and diffuse coagulopathy, as well as certain autoinflammatory conditions such as Kawasaki disease in children. We have reviewed the association between COVID‐19 and autoimmune disorders in this article.
Impact of proximal cap ambiguity on the procedural techniques and outcomes of chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS‐CTO Registry
Authors: Kostantinis Spyridon , Simsek Bahadir , Karacsonyi Judit , Rempakos Athanasios , Alaswad Khaldoon , Megaly Michael , Krestyaninov Oleg , Khelimskii Dmitrii , Karmpaliotis Dimitrios , Jaffer Farouc A. , Khatri Jaikirshan J. , Poommipanit Paul , Patel Mitul P. , Mahmud Ehtisham , Koutouzis Michael , Tsiafoutis Ioannis , Gorgulu Sevket , Elbarouni Basem , Nicholson William , Jaber Wissam , Rinfret Stephane , Abi Rafeh Nidal , Goktekin Omer , ElGuindy Ahmed M. , Allana Salman S. , Rangan Bavana V. , Sandoval Yader , Burke M. Nicholas , Brilakis Emmanouil S. 
Published: February 2023

AbstractBackgroundProximal cap ambiguity is a key parameter in the global chronic total occlusion (CTO) percutaneous coronary intervention (PCI) crossing algorithm.MethodsWe examined the baseline characteristics and procedural outcomes of 9718 CTO PCIs performed in 9498 patients at 41 US and non‐US centers between 2012 and 2022.ResultsProximal cap ambiguity was present in 35% of CTO lesions. Patients whose lesions had proximal cap ambiguity were more likely to have had prior coronary artery bypass graft surgery (37% vs. 24%; p < 0.001). Lesions with proximal cap ambiguity were more complex with higher J‐CTO score (3.1 ± 1.0 vs. 2.0 ± 1.2; p < 0.001) and lower technical (79% vs. 90%; p < 0.001) and procedural (77% vs. 89%; p < 0.001) success rates compared with nonambiguous CTO lesions. The incidence of major adverse cardiovascular events (MACE) was higher in cases with proximal cap ambiguity (2.5% vs. 1.7%; p < 0.001). The retrograde approach was more commonly used among cases with ambiguous proximal cap (50% vs. 21%; p < 0.001) and was more likely to be the final successful crossing strategy (29% vs. 13%; p < 0.001). The antegrade dissection and re‐entry (ADR) “move‐the‐cap” techniques were also more common among cases with proximal cap ambiguity.ConclusionsProximal cap ambiguity in CTO lesions is associated with higher utilization of the retrograde approach and ADR, lower technical and procedural success rates, and higher incidence of in‐hospital MACE.
Pt‐Promoted In2O3 Reduction and Reconstruction at the Pt/In2O3 Interface in CO2 Hydrogenation Atmosphere
Authors: Lu Ruichen , Zhang Xianze , Li Shuang‐Shuang , Wang Yingjie , Song Tinglu , Zhu Tong , Zhang Hui , Zheng Renkui , Zhang Xueqiang 
Published: February 2023

AbstractAs an essential path toward the elucidation of the reaction mechanism, the capture of the catalytically active phase and its evolution has been the primary goal of mechanistic studies. Here, the physicochemical properties on In2O3 (111) and Pt/In2O3 (111) thin film model catalysts were tracked in CO2 hydrogenation atmosphere under various pressures and temperatures by ambient pressure X‐ray photoelectron spectroscopy (APXPS). The redox behaviours of surface Pt and In2O3, the formation and interconversion of reaction intermediates, and the structural dynamics at the topmost surface, as a consequence of the outward diffusion of InOx species, nucleation of surface Pt nanostructures and the formation of PtInOx species, were captured and analyzed. The reconstruction at the Pt/In2O3 (111) interface was also observed by time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) and scanning electron microscopy (SEM) analysis. In‐situ spectroscopic and structural analysis on a well‐defined metal/metal‐oxide interface offers a powerful means to probe the mechanistic details of the heterogeneous processes.
Morpholinium‐Modified, Polyketone‐Based Anion Exchange Membranes for Water Electrolysis
Authors: Bonizzoni Simone , Stucchi Diego , Caielli Tommaso , Sediva Eva , Mauri Michele , Mustarelli Piercarlo 
Published: February 2023

AbstractWater electrolysis is by far the most appealing method to produce green hydrogen. Among the possible technologies, Anion Exchange Membrane (AEM) water electrolyzers are promising in the medium term, as they make it possible to avoid critical and noble materials as catalyst components. However, AEMs are still lacking in performance and stability, which has become the current research focus. Here, we report the facile and inexpensive chemical modification of polyketone (PK) with a functional unit encompassing morpholinium as the positively charged group, and the fabrication of self‐standing membranes. The synthesis products are investigated with an ensemble of physico‐chemical and spectroscopic techniques, including solid‐state and time‐domain NMR, FT‐IR, and thermal analysis. The membranes show good Ion Exchange Capacity values in the range 1.48–2.24 mmol g−1. A preliminary electrolysis test shows that the PK‐based membrane has performance comparable to that of a commercial one.
X‐Ray Microscopy: A Non‐Destructive Multi‐Scale Imaging to Study the Inner Workings of Batteries
Authors: Cognigni Flavio , Pasquali Mauro , Prosini Pier Paolo , Paoletti Claudia , Aurora Annalisa , Scaramuzzo Francesca Anna , Rossi Marco 
Published: February 2023

AbstractX‐ray microscopy (XRM) is a non‐destructive characterization technique that provides quantitative information regarding the morphology/composition of the specimen and allows to perform multiscale and multimodal 2D/3D experiments exploiting the radiation‐matter interactions. XRM is particularly suitable to afford in situ images of inner parts of a battery and for the early diagnosis of its degradation in a non‐invasive way. Since traditional characterization techniques (SEM, AFM, XRD) often require the removal of a component from the encapsulated device that may lead to non‐desired contamination of the sample, the non‐destructive multi‐scale potential of XRM represents an important improvement to batteries investigation. In this work, we present the advanced technical features that characterize a sub‐micron X‐ray microscopy system, its use for the investigation of hidden and internal structures of different types of batteries and to understand their behavior and evolution after many charge/discharge cycles.
Electrochemical Cycling Behaviour and Shape Changes of Zn Electrodes in Mildly Acidic Aqueous Electrolytes Containing Quaternary Ammonium Salts
Authors: Bozzini Benedetto , Boniardi Marco , Caielli Tommaso , Casaroli Andrea , Emanuele Elisa , Mancini Lucia , Sodini Nicola , Strada Jacopo 
Published: February 2023

AbstractSecondary Zn–based batteries are a valid alternative to Li for stationary storage, but commercial devices are not yet available, chiefly owing to anode shape‐change and passivation issues. Mildly acidic aqueous solutions are actively studied, since they seem to limit unstable growth of Zn, with respect to the alkaline ones, customary for primary batteries. Additives can further improve the performance of mildly acidic electrolytes. In this work we focus on the impact of a series of quaternary ammonium salts (TBAB, CTAB, DMDTDAB, BDMPAC, BPPEI, PDADMAC), selected to represent a comprehensive range of molecular functionalities. Electrochemical measurements (cyclic voltammetry, chronopotentiometry and galvanostatic‐cycling in split‐cells), combined with 2D and 3D imaging techniques (SEM, stereomicroscopy and in situ tomography) were adopted for the assessment Zn behaviour. This multi‐technique approach pinpointed TBAB as the single most effective additive for low‐current density operation, while at high current densities the additive‐free electrolyte allows better cycling performance, coherently with similar results for alkaline electrolytes.
Synthesis and Properties of B4N4‐Heteropentalenes Fused with Polycyclic Hydrocarbons
Authors: Kashida Junki , Shoji Yoshiaki , Taka Hideo , Fukushima Takanori 
Published: February 2023

AbstractHybrid molecules of π‐conjugated carbon rings and BN‐heterocyclic rings (h‐CBNs) fused with each other have been a rare class of compounds due to the limited availability of their synthetic methods. Here we report the synthesis of new h‐CBNs featuring a B4N4‐heteropentalene core and polycyclic aromatic hydrocarbon wings. Using 1,2‐azaborinine derivatives as a building block, we developed a rational synthetic protocol that allows the formation of a B4N4 ring in a stepwise manner, resulting in the fully fused ABA‐type triblock molecules. Thus, three derivatives of 1 bearing naphthalene (1Naph), anthracene (1Anth), or phenanthrene (1Phen) wings fused with the B4N4 core were synthesized and characterized. Among them, 1Phen, which displays the highest triplet‐state energy, was found to serve a host material for phosphorescent OLED devices, for which a maximum external quantum efficiency of 13.7 % was recorded. These findings may promote the synthesis of various types of h‐CBNs aiming at new properties arising from the synergy of two different π‐electronic systems.
Effective SrWO4/TiO2 Heterojunction with Enhanced Carriers Separation and Transfer for Photocatalytic Methane Oxidation
Authors: Huang Min , Zhang Shuyi , Gan Yongping , Liu Jin , He Zhanjun , Lin Tiejun , Yu Fei , Dai Yuanyuan , Niu Qiang , Zhong Liangshu 
Published: February 2023

AbstractPhotocatalytic methane oxidation to oxygenates with promising performance remains as a grand challenge due to the low productivity and severe overoxidation. Herein, SrWO4/TiO2 heterojunction was developed for photocatalytic methane oxidation with O2 to liquid oxygenates ( Please replace “oxygenates” with “oxygenated”)products under mild reaction conditions. The optimized SrWO4/TiO2 catalyst exhibited high productivity of 13365 μmol/g with high selectivity of 98.7 % for oxygenates. Benefited from the intimate heterojunction interface of SrWO4/TiO2, the constructed I‐type heterostructure improved the separation and transfer of photogenerated carriers, and a high‐speed transfer channel for photogenerated carriers was fabricated. Simultaneously, the special band structure can increase the amount of photogenerated electrons and holes on the TiO2 surface, which promoted the formation of reactive oxygen species to enhance liquid oxygenates productivity.
Synthesis of Sterically Encumbered Alkaline‐Earth Metal Amides Applying the In Situ Grignard Reagent Formation
Authors: Sengupta Simon , Schüler Philipp , Liebing Phil , Westerhausen Matthias 
Published: February 2023

AbstractMagnesium and calcium are too inert to deprotonate amines directly. For the synthesis of bulky amides alternative strategies are required and in the past,N‐bound trialkylsilyl groups have been used to ease metalation reactions. The in situGrignardreagent formation in stirred suspensions of magnesium or calcium with hydryl halide and imine in THF allows the synthesis of a plethora of amides with bulky silyl‐free substituents. Ball milling protocols partially favor competitive side reactions such as aza‐pinacol coupling reactions. Calcium is the advantageous choice for the in situGrignardreagent formation and subsequent addition onto the imines yielding bulky calcium bis(amides) whereas the stronger reducing heavier alkaline‐earth metals strontium and barium are less selective and hence, the aza‐pinacol coupling reaction becomes competitive. Exemplary, the solid‐state molecular structures of [(Et2O)Mg(N(Ph)(CHPh2)2] and [(Et2O)2Ca(N(Ph)(CHPh2)2] have been determined.
AuNP‐Modulated qPCR: An Optimized System for Detecting MIR Biophotons Released in DNA Replication
Authors: Yang Yu , Peng Daoling , Gu Zhenglong , Jiang Lei , Song Bo 
Published: February 2023

AbstractInvited for the cover of this issue are Lei Jiang and Bo Song at the University of Shanghai for Science and Technology and the Technical Institute of Physics and Chemistry (CAS), and colleagues at Fudan University and South China Normal University. The image depicts how the hydrolysis of cellular energy molecules (i.e., ATP and dNTPs) releases mid‐infrared photons to efficiently drive biological processes including DNA replication. Read the full text of the article at 10.1002/chem.202203513.
Thermoset/graphene polymer composites—A review of processing and properties
Authors: Lashkari Piyush , Divigalpitiya Ranjith , Hrymak Andrew N. 
Published: February 2023

AbstractPolymer‐carbon nanocomposites incorporate the exceptional properties of both the polymer matrices, such as low cost and simple processing, with the distinctive features of the carbon‐based fillers, such as high electrical and thermal conductivities, and excellent mechanical properties. Various fillers like carbon black (CB), graphite, expanded graphite (EG), and carbon nanotubes (CNTs) are being used to produce materials with advanced properties. However, at high filler loading, these filler materials have some major challenges such as filler agglomeration. Recently, graphene has gained increased interest as an alternative filler to produce polymer nanocomposites with advanced characteristics. Thermosetting polymer composites with graphene fillers are being considered for multiple applications and are a subject of interest for researchers because of enhanced properties like excellent corrosion resistance and low density. This review outlines studies to improve the mechanical, electrical, and thermal properties of thermoset/graphene composites.
PROTOCOL: Case management interventions seeking to counter radicalisation to violence: A systematic review of tools and approaches
Authors: Lewis James , Marsden Sarah , Cherney Adrian , Zeuthen Martine , Bélanger Jocelyn J. , Zubareva Anastasiia , Brandsch Jürgen , Lubrano Mauro 
Published: February 2023

AbstractThis systematic review consists of two parts. Part I seeks to synthesise evidence from primary or secondary research studies examining the implementation and effectiveness of case management tools and approaches currently being used to counter radicalisation to violence. Part II is an ‘overview of reviews’ that seeks to identify relevant and transferable lessons from systematic reviews and meta‐analyses of case management tools and approaches used in the broader field of violence prevention that could be applied to counter‐radicalisation practice.