bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-meter-level navigation with an enhanced multi-GNSS single-point positioning algorithm using iGMAS ultra-rapid products
Authors: Birinci Sinan , Saka Mehmet Halis 
Published: February 2023

AbstractUltra-rapid products have the advantage of being used in real-time positioning with no external connections. In this study, these products provided by the international GNSS Monitoring and Assessment System (iGMAS) for four global constellations (GPS, GLONASS, Galileo and BDS-3) were assessed in terms of service rate and accuracy in navigation. In this regard, a MATLAB-based in-house code solving the problem was developed for all possible combinations of the constellations. To explore the effectiveness of the iGMAS products, the same dataset has been also processed using GFZ rapid products. The results demonstrate that the GPS and Galileo solutions were substantially comparable to the rapid products concerning service rate and accuracy, but that the GLONASS and BDS-3 iGMAS products require some enhancements. In addition, the Galileo solution produced remarkably good results both individually and in combination. The GPS/GLONASS/Galileo/BDS-3 SPP solution generated a mean root mean square (RMS) error of 0 ⋅ 54 m horizontally and 0 ⋅ 89 m vertically. Thus, GPS-only, GLONASS-only, Galileo-only and BDS-3-only solutions were improved by 42%, 79%, 28% and 74% in 3D mean RMS error with the quad system solutions, respectively.
Risk and resilience factors for psychopathology during pregnancy: An application of the Hierarchical Taxonomy of Psychopathology (HiTOP)
Authors: Clark Hannah M. , Hankin Benjamin L. , Narayan Angela J. , Davis Elysia Poggi 
Published: February 2023

AbstractPregnancy is a time of increased vulnerability to psychopathology, yet limited work has investigated the extent to which variation in psychopathology during pregnancy is shared and unshared across syndromes and symptoms. Understanding the structure of psychopathology during pregnancy, including associations with childhood experiences, may elucidate risk and resilience factors that are transdiagnostic and/or specific to particular psychopathology phenotypes. Participants were 292 pregnant individuals assessed using multiple measures of psychopathology. Confirmatory factor analyses found evidence for a structure of psychopathology consistent with the Hierarchical Taxonomy of Psychopathology (HiTOP). A common transdiagnostic factor accounted for most variation in psychopathology, and both adverse and benevolent childhood experiences (ACEs and BCEs) were associated with this transdiagnostic factor. Furthermore, pregnancy-specific anxiety symptoms most closely reflected the dimension of Fear, which may suggest shared variation with manifestations of fear that are not pregnancy-specific. ACEs and BCEs also linked to specific prenatal psychopathology involving thought problems, detachment, and internalizing, externalizing, antagonistic, and antisocial behavior. These findings extend the dimensional and hierarchical HiTOP model to pregnant individuals and show how maternal childhood risk and resilience factors relate to common and specific forms of psychopathology during pregnancy as a period of enhanced vulnerability.
Do quantitative levels of cardiac troponin I implicate on severity of disease in children, adolescences, and young adults with acute myocarditis and myopericarditis?
Authors: Brosilow Sharon , Zaid Wisam Abo , Maghen Daniel , Khoury Asaad , Aharonson Doron , Lorber Avraham 
Published: February 2023

AbstractObjectives:When cardiac muscle damage occurs, cardiac troponins are released to blood and their detection is used as a marker in clinical setting. The prognostic value of the quantitative levels of blood troponin I in cases of myocarditis and myopericarditis is unclear. The aim of this study was to analyse whether troponin quantitative blood levels can be correlated with the course of hospitalisation and prognosis.Methods:Retrospective data was collected from all consecutive patients aged ≤30 hospitalised with a diagnosis of acute myocarditis or acute myopericarditis in our health Care Campus between the years 2010–2016.Results:Ninety-three patients with myocarditis and myopericarditis were identified. Higher peak troponin levels correlated with longer hospitalisation times in the cardiac or paediatric wards (p = 0.03, Pearson correlation: r −0.23), and median troponin level at admission correlated with longer overall hospitalisation (p = 0.026, Pearson correlation: r = 0.23). Patients admitted to ICU, received oral cardiac supportive therapy or that were discharged with cardiac drugs had higher median troponin compared to patients who were not but this was not statistically significant. A small group of patients that needed intravenous cardiac support had significantly lower median peak troponin levels (n = 4, 0.375ng/ml, p = 0.048). Only two patients needed extracorporeal membrane oxygenation support, and one died. The small number of patients precludes statistical analysis.Conclusion:Higher troponin levels correlated significantly with longer hospitalisation, lower troponin values correlated with intravenous cardiac support, while other variables related to the severity of disease could not be significantly related to higher troponin levels.
Laboratory Earthquakes Simulations—Typical Events, Fault Damage, and Gouge Production
Authors: Mollon Guilhem , Aubry Jérôme , Schubnel Alexandre 
Published: February 2023

AbstractWe propose a numerical model of laboratory earthquake cycle inspired by a set of experiments performed on a triaxial apparatus on sawcut Carrara marble samples. The model couples two representations of rock matter: rock is essentially represented as an elastic continuum, except in the vicinity of the sliding interface, where a discrete representation is employed. This allows to simulate in a single framework the storage and release of strain energy in the bulk of the sample and in the loading system, the damage of rock due to sliding, and the progressive production of a granular gouge layer in the interface. After independent calibration, we find that the tribosystem spontaneously evolves toward a stick‐slip sliding regime, mimicking in a satisfactory way the behavior observed in the lab. The model offers insights on complex phenomena which are out of reach in experiments. This includes the variability in space and time of the fields of stress and effective friction along the fault, the progressive thickening of the damaged region of rock around the interface, and the build‐up of a granular layer of gouge accommodating shear. We present in detail several typical sliding events, we illustrate the fault heterogeneity, and we analyze quantitatively the damage rate in the numerical samples. Some limitations of the model are pointed out, as well as ideas of future improvements, and several research directions are proposed in order to further explore the large numerical data set produced by these simulations.
Seasonality of the Sub‐Mesoscale to Mesoscale Sea Surface Variability From Multi‐Year Satellite Altimetry
Authors: Yu Y. , Sandwell D. T. , Gille S. T. 
Published: February 2023

AbstractSea surface slope (SSS) varies in response to a range of physical processes: tides, geostrophic flows, surface and internal waves, etc. We present the sea surface variation in the form of the SSS variability using 30 years of heterogeneous satellite altimetry measurements. We apply band‐pass filters to the along‐track SSS, and derive the mean and seasonal (annual and semi‐annual) components of SSS variability in multiple wavelength sub‐bands from 10 to 1,000 km. We show that the seasonal components are generally small (<10% in amplitude) compared to the mean variability. Through correlation analysis, we show evidence that SSS variability with wavelengths less than 30 km is dominated by wave height noise. At sub‐mesoscale to mesoscale (30–100 km) wavelengths, we identify high variability over western boundary currents and regions of rough topography. In this band, the high‐latitude Northern Hemisphere and the south Indian Ocean are associated with large annual cycles. The variability is higher in local wintertime except for a few regions, for example, the Bay of Bengal, which shows high variability in the boreal spring and fall. Through power spectral density analysis of the seasonal SSS variability, we find that the energy differences between local winter and summer are stronger at smaller scales (<100 km). The Ka‐band radar interferometry instrument on the Surface Water and Ocean Topography satellite mission will allow observation of ocean surface activities down to ∼20 km at submonthly time scales, but wave‐related errors (sea state bias, aliasing, wind‐driven activities, etc.) will still be a major challenge.
Evolution of an Accretionary Complex (LeMay Group) and Terrane Translation in the Antarctic Peninsula
Authors: Riley Teal R. , Millar Ian L. , Carter Andrew , Flowerdew Michael J. , Burton‐Johnson Alex , Bastias Joaquin , Storey Craig D. , Castillo Paula , Chew David , Whitehouse Martin J. 
Published: February 2023

AbstractThe LeMay Group accretionary complex of Alexander Island (Antarctic Peninsula) comprises a 4 km thick succession of variably deformed turbidites associated with thrust slices of ocean floor basalts. The depositional age and provenance of the succession is uncertain with estimates ranging from Carboniferous to Cretaceous. The accretion history is also poorly established and whether the LeMay Group developed allochthonously and accreted during an episode of Cretaceous terrane translation. We have examined the geochronology and geochemistry of 22 samples from across the entire accretionary complex to determine its depositional, provenance and accretion history. The accretionary complex has been subdivided into four separate groups based on detrital zircon U‐Pb age and Lu‐Hf provenance analysis. Groups 1 and 2 are interpreted to be a continuation of the extensive Permian accretionary complexes of West Gondwana and have a depositional age of c. 255 Ma, with volcaniclastic input from the extensive silicic volcanism of the Choiyoi Province. Accretion of the LeMay Group to the continental margin developed during the mid‐Triassic, potentially related to the Peninsula Orogeny and an episode of flat‐slab subduction of the proto‐Pacific plate. Group 3 is only identified from an island to the west of Alexander Island and has a mid‐Cretaceous depositional age and provenance akin to offshore sequences from Thurston Island. A para‐autochthonous origin is suggested, with mid‐Cretaceous accretion associated with the melange belts of central Alexander Island. Group 4 is also a distinct unit with an Early Jurassic depositional age and a source more closely related to the Antarctic Peninsula.
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Authors: Honorato-Mauer Jessica , Xavier Gabriela , Ota Vanessa Kiyomi , Chehimi Samar Nasser , Mafra Fernanda , Cuóco Cássia , Ito Lucas Toshio , Ormond Rafaella , Asprino Paula Fontes , Oliveira Adrielle , Bugiga Amanda Victoria Gomes , Torrecilhas Ana Claudia , Bressan Rodrigo , Manfro Gisele Gus , Miguel Euripedes Constantino , Rohde Luis Augusto , Pan Pedro Mario , Salum Giovanni Abrahão , Pellegrino Renata , Belangero Sintia , Santoro Marcos Leite 
Published: February 2023

AbstractExtracellular vesicles (EVs) are present in numerous peripheral bodily fluids and function in critical biological processes, including cell-to-cell communication. Most relevant to the present study, EVs contain microRNAs (miRNAs), and initial evidence from the field indicates that miRNAs detected in circulating EVs have been previously associated with mental health disorders. Here, we conducted an exploratory longitudinal and cross-sectional analysis of miRNA expression in serum EVs from adolescent participants. We analyzed data from a larger ongoing cohort study, evaluating 116 adolescent participants at two time points (wave 1 and wave 2) separated by three years. Two separate data analyses were employed: A cross-sectional analysis compared individuals diagnosed with Major Depressive Disorder (MDD), Anxiety disorders (ANX) and Attention deficit/Hyperactivity disorder (ADHD) with individuals without psychiatric diagnosis at each time point. A longitudinal analysis assessed changes in miRNA expression over time between four groups showing different diagnostic trajectories (persistent diagnosis, first incidence, remitted and typically developing/control). Total EVs were isolated, characterized by size distribution and membrane proteins, and miRNAs were isolated and sequenced. We then selected differentially expressed miRNAs for target prediction and pathway enrichment analysis. In the longitudinal analysis, we did not observe any statistically significant results. In the cross-sectional analysis: in the ADHD group, we observed an upregulation of miR-328-3p at wave 1 only; in the MDD group, we observed a downregulation of miR-4433b-5p, miR-584-5p, miR-625-3p, miR-432-5p and miR-409-3p at wave 2 only; and in the ANX group, we observed a downregulation of miR-432-5p, miR-151a-5p and miR-584-5p in ANX cases at wave 2 only. Our results identified previously observed and novel differentially expressed miRNAs and their relationship with three mental health disorders. These data are consistent with the notion that these miRNAs might regulate the expression of genes associated with these traits in genome-wide association studies. The findings support the promise of continued identification of miRNAs contained within peripheral EVs as biomarkers for mental health disorders.
Acute stress responses of autonomous nervous system, HPA axis, and inflammatory system in posttraumatic stress disorder
Authors: von Majewski Kristin , Kraus Olga , Rhein Cosima , Lieb Marietta , Erim Yesim , Rohleder Nicolas 
Published: February 2023

AbstractPosttraumatic stress disorder (PTSD) does not only have direct consequences for well-being, but it also comes with a significant risk for severe somatic health consequences. A number of previous studies have pointed to alterations in stress systems in traumatized persons, as well as the inflammatory system, which might be important links in the pathway between trauma, PTSD, and health consequences. The aim of this study was to investigate acute stress responses in PTSD patients compared with healthy controls. Twenty-seven PTSD patients and 15 controls were exposed to the Trier Social Stress Test (TSST), and we measured salivary cortisol, salivary alpha-amylase (sAA), plasma interleukin-6 (IL-6), as well as heart rate and heart rate variability (HRV) at different time points before, during and after the stress test. Results revealed similar stress responses between patients and controls, but lower baseline cortisol levels and higher IL-6 baseline levels in PTSD patients. Increases in sAA stress responses were significantly lower in patients, while sAA concentrations were higher in the PTSD group during intervention. HRV was markedly decreased in patients and showed a significantly blunted acute stress response with a slower recovery after TSST. These results confirm previous findings of marked stress system dysregulations in PTSD and add to the literature on acute stress reactivity in PTSD which appears to show stress system-specific changes. Overall, these results have implications for our understanding of potential risk and resilience factors in the response to trauma.
Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics
Authors: Ogiya Daisuke , Chyra Zuzana , Verselis Sigitas J. , O’Keefe Morgan , Cobb Jacquelyn , Abiatari Ivane , Talluri Srikanth , Sithara Anjana Anilkumar , Hideshima Teru , Chu Michael P. , Hájek Roman , Dorfman David M. , Pilarski Linda M. , Anderson Kenneth C. , Adamia Sophia 
Published: February 2023

AbstractNovel drug discoveries have shifted the treatment paradigms of most hematological malignancies, including multiple myeloma (MM). However, this plasma cell malignancy remains incurable, and novel therapies are therefore urgently needed. Whole-genome transcriptome analyses in a large cohort of MM patients demonstrated that alterations in pre-mRNA splicing (AS) are frequent in MM. This manuscript describes approaches to identify disease-specific alterations in MM and proposes RNA-based therapeutic strategies to eradicate such alterations. As a “proof of concept”, we examined the causes of aberrant HMMR (Hyaluronan-mediated motility receptor) splicing in MM. We identified clusters of single nucleotide variations (SNVs) in the HMMR transcript where the altered splicing took place. Using bioinformatics tools, we predicted SNVs and splicing factors that potentially contribute to aberrant HMMR splicing. Based on bioinformatic analyses and validation studies, we provided the rationale for RNA-based therapeutic strategies to selectively inhibit altered HMMR splicing in MM. Since splicing is a hallmark of many cancers, strategies described herein for target identification and the design of RNA-based therapeutics that inhibit gene splicing can be applied not only to other genes in MM but also more broadly to other hematological malignancies and solid tumors as well.
What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?
Authors: Asayama Kei , Stolarz-Skrzypek Katarzyna , Yang Wen-Yi , Hansen Tine W. , Brguljan-Hitij Jana , Odili Augustine N. , Li Yan , Staessen Jan A. 
Published: February 2023

AbstractTo assess in individual-person meta-analyses how out-of-office blood pressure (BP) contributes to risk stratification and the management of hypertension, an international consortium set up the International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome. This review summarizes key findings of recent IDACO/IDHOCO articles. Among various BP indexes derived from office and ambulatory BP recordings, the 24-h and nighttime BP level were the best predictors of adverse health outcomes. Second, using the 10-year cardiovascular risk associated with guideline-endorsed office BP thresholds as reference, corresponding thresholds were derived for home and ambulatory BP. Stratified by the underlying cardiovascular risk, the rate of cardiovascular events in white-coat hypertensive patients and matched normotensive controls were not substantially different. The observation that masked hypertension carries a high cardiovascular risk was replicated in Nigerian Blacks, using home BP monitoring. The thresholds for 24-h mean arterial pressure, i.e., the BP component measured by oscillometric devices, delineating normotension, elevated BP and hypertension were <90, 90 to 92 and ≥92 mmHg. At young age, the absolute risk associated with out-of-office BP was low, but the relative risk was high, whereas with advancing age, the relative risk decreased and the absolute risk increased. Using pulse pressure as an exemplary case, the relative risks of death, cardiovascular endpoints and stroke decreased over 3-fold from 55 to 75 years of age, whereas in contrast absolute risk rose 3-fold. In conclusion, IDACO/IDHOCO forcefully support the notion that the pressing need to curb the hypertension pandemic cannot be met without out-of-the-office BP monitoring.
Photothermal bleaching of nickel dithiolene for bright multi-colored 3D printed parts
Authors: Olubummo Adekunle , Zhao Lihua , Hartman Aja , Tom Howard , Zhao Yan , Wycoff Kyle 
Published: February 2023

AbstractHP’s Multi Jet Fusion is a powder bed fusion 3D printing technology that utilizes a carbon-based radiation absorber in combination with a near infrared (NIR) light source to facilitate the fusion of polymer powder in a layer-by-layer fashion to generate 3D parts. Most available carbon-based and NIR radiation absorbers have an intrinsic dark color, which as a result will only produce black/gray and dark colored parts. However, there are many applications that require variable color, including prosthetics, medical models, and indicators, among others. To create white, bright colored, and translucent parts with MJF, a visibly transparent and colorless radiation absorber is required. In this paper, we designed an activating fusing agent (AFA) that contains a red, strong NIR absorbing dye that turns colorless after harvesting irradiation energy during the MJF 3D printing process and provide a bright colored part when working with other color agents.
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle
Authors: Marchioretti Caterina , Zanetti Giulia , Pirazzini Marco , Gherardi Gaia , Nogara Leonardo , Andreotti Roberta , Martini Paolo , Marcucci Lorenzo , Canato Marta , Nath Samir R. , Zuccaro Emanuela , Chivet Mathilde , Mammucari Cristina , Pacifici Marco , Raffaello Anna , Rizzuto Rosario , Mattarei Andrea , Desbats Maria A. , Salviati Leonardo , Megighian Aram , Sorarù Gianni , Pegoraro Elena , Belluzzi Elisa , Pozzuoli Assunta , Biz Carlo , Ruggieri Pietro , Romualdi Chiara , Lieberman Andrew P. , Babu Gopal J. , Sandri Marco , Blaauw Bert , Basso Manuela , Pennuto Maria 
Published: February 2023

AbstractPolyglutamine expansion in the androgen receptor (AR) causes spinobulbar muscular atrophy (SBMA). Skeletal muscle is a primary site of toxicity; however, the current understanding of the early pathological processes that occur and how they unfold during disease progression remains limited. Using transgenic and knock-in mice and patient-derived muscle biopsies, we show that SBMA mice in the presymptomatic stage develop a respiratory defect matching defective expression of genes involved in excitation-contraction coupling (ECC), altered contraction dynamics, and increased fatigue. These processes are followed by stimulus-dependent accumulation of calcium into mitochondria and structural disorganization of the muscle triads. Deregulation of expression of ECC genes is concomitant with sexual maturity and androgen raise in the serum. Consistent with the androgen-dependent nature of these alterations, surgical castration and AR silencing alleviate the early and late pathological processes. These observations show that ECC deregulation and defective mitochondrial respiration are early but reversible events followed by altered muscle force, calcium dyshomeostasis, and dismantling of triad structure.
SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection
Authors: Pušnik Jernej , Monzon-Posadas Werner O. , Zorn Jasmin , Peters Kathrin , Baum Maximilian , Proksch Hannah , Schlüter Celina Beta , Alter Galit , Menting Tanja , Streeck Hendrik 
Published: February 2023

AbstractThe elicited anti-SARS-CoV-2 immunity is becoming increasingly complex with individuals receiving a different number of vaccine doses paired with or without recovery from breakthrough infections with different variants. Here we analyze the immunity of individuals that initially received two doses of mRNA vaccine and either received a booster vaccination, recovered from a breakthrough infection, or both. Our data suggest that two vaccine doses and delta breakthrough infection or three vaccine doses and optionally omicron or delta infection provide better B cell immunity than the initial two doses of mRNA vaccine with or without alpha breakthrough infection. A particularly potent B cell response against the currently circulating omicron variant (B. 1.1.529) was observed for thrice vaccinated individuals with omicron breakthrough infection; a 46-fold increase in plasma neutralization compared to two vaccine doses (p < 0.0001). The T cell response after two vaccine doses is not significantly influenced by additional antigen exposures. Of note, individuals with hybrid immunity show better correlated adaptive immune responses compared to those only vaccinated. Taken together, our data provide a detailed insight into SARS-CoV-2 immunity following different antigen exposure scenarios.