bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced cyber security using Spectral entity feature selection based on Cyber Crypto Proof Security Protocol (C2PSP)
Authors: S GOPALAKRISHNAN , Saikia Karabi , Vallem Ranadheer Reddy 
Published: February 2023

The growth of internet become more development in communication medium to provide various services. Information sharing ad security is mostly suffered by crime attackers because of different models of cyber-attacks are carried out by attackers. Attackers creates jamming principles, communication delays, packet dropping, and information hacking, duplicate injection to do so many activities to destroy the security. Based on the communication data analysis and features are non-identified and difficult to find the malicious activities. So the development of cyber security needs advancement to find the attackers based on the communication breaking activities. To resolve this problem, we propose a Spectral entity feature selection based Cyber Crypto Proof Security Protocol (C2PSP) to improve the cyber security. The Defect Scaling Rate (DSR) is used to estimate the communication defect rate. By marginalize the scaling rate using Spectral entity feature selection approach (SEFSA) is applied to select the features and trained to identify with Artificial neural network classifier (ANN). Based on the attack principles and activities in communication medium, the Cyber Crypto Proof Security Protocol (C2PSP) is applied to ensure the security verification and validation to process the data safer and securely. The proposed system produce high performance compared to other system as well to identify the malicious activities to improve the security against the cyber-attacks
Strategi Pemasaran BMT Al Makmur dalam Meningkatkan Jumlah Nasabah Fundig dimasa Pandemi Covid-19
Authors: Mariko Suhatri 
Published: February 2023

Pokok permasalahan penelitian ini adalah Strategi Pemasaran yang diggunakan oleh BMT Al Makmur dalam meningkatkan jumlah nasabah Funding dimasa Pandemi Covid-19.Tujuan pembahasan ini untuk mengetahui dan menganalisis Strategi Pemasaran yang diggunakan oleh BMT Al Makmur dalam meningkatkan jumlah nasabah Funding dimasa Pandemi Covid-19. Jenis penelitian yang penulis gunakan adalah penelitian lapangan (field research) dengan pendekatan deskriptif kualitatif.Teknik pengumpulan data adalah dengan observasi, wawancara dan dokumentasi. Dari penelitian yang dilakukan ditemukan bahwa Strategi pemasaran yang dilakukan BMT Al Makmur untuk meningkatkan jumlah nasabah dimasa Pandemi Covid -19 adalah Pertama Mengoptimalkan peran dan fungsi tenaga marketing, Kedua Mengoptimalkan Strategi Pemasaran Personal Selling (Penjualan Pribadi), Ketiga Memberikan Service Exellence kepada nasabah, Keempat Membangun dan menjalin Sinergisitas aktif dengan pemerintah dan lembaga yang ada di wilayah kerja.
Screening of Parents and Hybrids Resistant to Late Blight and Leaf Curl Virus Diseases in Tomato
Authors: Kherwa Radhe Shyam , Solankey S. S. , Akhtar Shirin , Kumar Mahendra 
Published: February 2023

The experimental material included 21 F1 hybrids (developed by half diallel fashion), 7 parents and standard check were all planted in randomized complete block design with three replications at Bihar Agriculture University, Sabour. Among the parents Pusa Rohini, Arka Vikash and S. pimpinellifolium whereas, among the crosses, Pusa Rohini × Arka Vikash, H-86 × Arka Vikash and Arka Vikash × S. pimpinellifolium were showed highly resistant for per cent disease incidence and coefficient of infection of late blight and ToLCV. Maximum heterosis over better parent and standard parent in desirable direction were found in Pusa Rohini × Arka Vikash (-48.61, -52.84), (-72.12, -76.42) and Arka Vikash × Arka Abha (-42.02, -50.35), (-61.35, -75.17) for per cent disease incidence and coefficient of infection of late blight. Whereas heterosis for PDI and CI of ToLCV was found in cross combinations namely, Pusa Rohini × S. pimpinellifolium (-46.35, -65.08), (-77.50, -88.35) and Arka Vikash × S. pimpinellifolium (-60.85, -64.32) (-86.95, -88.27) over better parent and standard parent. The cross identified as best specific combiners Arka Vikash × S. pimpinellifolium for per cent disease incidence and coefficient of infection of late blight and ToLCV. Among the parents for late blight the per cent disease incidence and coefficient of infection were significantly shown by Arka Vikash and Arka Abha. Against ToLCV (PDI and CI) resistance, parents Pusa Rohini, S. pimpinellifolium and Arka Vikash were exhibited significantly negative GCA effect.
Implementation of the Marrakech Framework for Action in the Context of the Sustainable Development Goals: UNESCO and Global Cooperation Frameworks
Authors: Hinzen Heribert , Medel‐Anonuevo Carolyn , Németh Balázs 
Published: February 2025

ABSTRACTThe United Nations Educational, Scientific and Cultural Organisation (UNESCO) was established in 1945, shortly after World War I. Peace was a key concern. As part of the human right to education, adults and their education and learning needs have received greater attention and recognition through a number of international conferences and recommendations. UNESCO has also initiated global reports on the development of education, looking through the lens of lifelong learning as a new paradigm. This perspective could also be applied when the Sustainable Development Goals were agreed upon by the United Nations. The article follows some important milestones during those 80 years, especially with a more detailed view of the UNESCO Global Network on Learning Cities.
Inhibitory Microenvironment Remodeling Enhances STING Activation for Solid Tumor Immunotherapy
Authors: Fang Wenming , Chen Lizhu , Hu Ping , Shi Jianlin 
Published: February 2025

AbstractThe immunomodulatory effect of the interferon gene‐stimulating factor (STING) pathway makes it an important target for tumor immunotherapy, which, however, suffers from the easy degradation and deteriorated stimulatory capacity of current STING agonists in the solid tumor microenvironment. Herein, a nanocomposite medicine， MLAP， is constructed by intercalating STING agonist ADU‐S100 into Mn‐doped layered double hydroxide, which is capable of modulating the immune microenvironment of solid tumors to enhance STING activation. Importantly, the intercalation in the interlayer structure enhances the intracellular permeability of STING agonists, meanwhile, the activation of the STING pathway by ADU‐S100 is amplified by the sensitizing effect of Mn2+. In addition, the moderate alkalinity of MLAP neutralizes the acidity of the tumor microenvironment and catalyzes the decomposition of hydrogen peroxide to produce oxygen, rectifying the acidic and hypoxia immunosuppressive microenvironment and thus strengthening the immune activation efficacy of STING agonists. This work provides an excellent carrier for STING agonists, which not only improves the bioavailability of STING agonists but also remodels the immune microenvironment for boosted solid tumor immunotherapy.
A Safe, Stable, Simple, Serviceable, and Self‐Powered Wound Dressing With Continuous Low‐Voltage Direct Current Electrical Stimulation: an Efficient Approach to Accelerate Wound Healing
Authors: Shi Chenxi , Wang Huan , Wang Xiaojing , Li Kefeng , Liu Pengbi , Wang Lihuan , Yu Hui 
Published: February 2025

AbstractElectrical stimulation (ES) dressings have garnered considerable attention owing to their profound impact on chronic wound care, while the existing ES dressings necessitate external power supply or intricate structures, posing potential safety risks and usage inconveniences. Herein, a safe, stable, simple, serviceable, and self‐powered (5S) ES dressing composed of an electrospinning asymmetric nanofiber membrane with screen‐printed electrodes and a polyurethane foam is developed. The asymmetric nanofiber membrane acts as the power due to its electrical double‐layer effect during the unidirectional exudate transfer, and the polyurethane foam with excellent water absorption and retention properties effectively manages the exudate. This 5S dressing generates a sustained low‐voltage direct current ES in situ at the wound site and creates a favorable microenvironment for wound re‐epithelization. In vitro and in vivo studies indicate that this 5S dressing can significantly promote wound healing. Compared with the control group (on the 7th day), the collagen deposition of the 5S dressing treated group increased by 15.9%, the capillary density increased by 90.6%, and the epidermal thickness increased by 228.3%, resulting in a 23.6% enhancement in the wound healing rate. Consequently, the 5S wound dressing presents a highly sophisticated and effective therapeutic approach for accelerating wound healing.
From MXene to Multimodal‐Responsive Smart, Durable Electromagnetic Interference Shielding Textiles
Authors: Wei Meng , Wu Na , Li Bin , Liu Jishang , Pan Fei , Liu Jiurong , Zeng Zhihui 
Published: February 2025

AbstractAchieving wearable, multifunctional e‐textiles with high mechanical properties, exceptional environmental durability, and intelligent, responsive capabilities remains a significant challenge. Here, novel high‐strength, environmentally adaptable, and intelligent electromagnetic interference (EMI) shielding fibers/e‐textiles composed of polyvinyl alcohol‐assisted multiple crosslinking MXene nanosheets are prepared through a facile, scalable wet spinning approach. The synergistic effect of hydrogen, ionic, and covalent bonds significantly enhances the mechanical properties, hydrophobicity, waterproof capability, and oxidation resistance of MXene‐embedded fibers/textiles, contributing to the reliability and durability of wearable textiles even in harsh environments. Moreover, through the high‐efficiency utilization of PVA and MXene, the textiles can achieve dynamic, wide‐ranging control of EMI SE with multimodal response involving orientation, humidity, and light/electric stimuli. The novel type of textiles acting as intelligent, smart EMI shielding “On/Off” or “High/Low” switches are demonstrated. Combined with the multifunctionalities of thermal therapy, deicing, and antibacterial implemented, the high‐strength, environmentally adaptive, and multimodal‐responsive MXene‐embedded smart EMI shielding e‐textiles show great promise for advancing the development of next‐generation, wearable, smart electronics.
Multimodal Antibacterial E‐Skin Patch Driven by Oxidative Stress for Real‐Time Wound‐Status Monitoring and Integrated Treatment of Chronic Wounds
Authors: Liu Wanling , Ye Juncheng , Wang Yanlang , Xu Xiaobo , Gao Yujie , Liu Kangyu , Gao Jiefeng , Lin Yihong , Cui Lei , Wu Qiaoyi , Yang Huanghao , Zhang Jin 
Published: February 2025

AbstractHealing of chronic wounds becomes a global health issue due to increasing incidence and associated burdens, and therefore promoting tissue‐remodeling and monitoring wound‐status visually are of particular significance. Herein, an electronic‐skin patch (TENG‐gel) composed by polydimethylsiloxane/polytetrafluoroethylene film, eutectic gallium–indium (E‐GaIn), and quaternary chitosan/polyacrylamide/sodium alginate@molybdenum disulfide (MoS2) nanosheet (HQPS@MoS2) composite hydrogel is assembled layer‐by‐layer. First, the TENG‐gel realizes multimodal antibacterial by integrating peroxidase‐like activity, photothermal therapy, and nano‐knife effect, which eliminates both Gram‐positive/negative bacteria with killing ratio of above 95%. Besides, electrical stimulation generated from the TENG‐gel promotes migration of fibroblasts after an incubation of 48 h by activating signaling pathways, and meanwhile accelerates vascularization by secreting different growth factors of CD31, VEGF, and TGF‐β. Through providing an ideal microenvironment for tissue repair, the TENG‐gel achieves 1.6‐fold new hair follicles and 2.4‐fold collagen deposition compared with those of the control group. More interestingly, dual temperature‐/strain‐sensing performance enables the TENG‐gel with capability of monitoring wound status or reminding external danger signals in real‐time dependent on variational electrical signals. Overall, unique advantages of such smart electronic‐skin patch provide a personalized medicine strategy for realizing tissue reconstruction and monitoring synchronously.
Realising Bio‐Synapse Analogous Paired‐Pulse Facilitation (PPF) and Release Inactivation (RI) and Emulating "Tip of the Tongue" Experience Through Conductance and Retention Dynamics in Ag Nano‐Labyrinth‐Based Neuromorphic Device
Authors: Pal Mousona , Vidhyadhiraja N Sudhindra , Kulkarni Giridhar U. 
Published: February 2025

AbstractIn bio‐neural networks, pairing of consecutive action potentials based on the time interval in between, known as paired‐pulse facilitation (PPF), is crucial in enhancing synaptic strength and duration. However, at lower time intervals, release inactivation (RI) may set in diminishing the effect of pairing of potentials. While the neuromorphic version of PPF is extensively studied in the literature, aspects related to RI are largely ignored. This study presents a novel two‐terminal resistive device utilizing a dewetting‐engineered Ag labyrinth structure, designed to emulate the PPF and RI observed in biological synapses. The pulse pairing effect is observed not only based on conductance (G) but also its retention time (tr), with PPF(G) reaching a maximum of ≈2.65 and PPF(tr) ≈12.6. Furthermore, a unique second‐order PPF effect is observed when a time interval larger than the first retention is employed; in instances where the retention ended right before the second pulse within a very small interval, pairing effects can still be seen, akin to the “tip of the tongue” experience in humans. Utilizing such inherent volatility of the device is particularly significant for dynamical neural network‐based reservoir computing (RC).
Metastable Calcium Phosphate Cluster‐Involved Mineralization Process Regulated by a Dual Biomolecule System Toward the Application in Dentinal Tubules Occlusion
Authors: Xu Xiaochen , Luo Nan , Ru Jing , Zeng Hua , Liu Xiaohao , Tan Shuo , Chen Feng , Lu Bing‐Qiang , Chen Xi 
Published: February 2025

AbstractDentin hypersensitivity caused by the exposure of dentinal tubules is affecting a significant portion of the population. With promising prospects, the biomimetic mineralization materials used in treating dentin hypersensitivity are expected to possess a metastable characteristic, for which they can easily penetrate the tubules and the surrounding tissues, but then occlude them via a transformation of size and phase immediately. Herein, this study develops a metastable calcium phosphate cluster (MCPC)‐involved mineralization process, which is regulated by dual biological macromolecules: bovine serum albumin (BSA) and poly‐L‐lysine (PLL). BSA functions to stabilize the primary calcium phosphate clusters; PLL further tunes the cluster's evolution (toward larger and crystalline particles) into a metastable fashion, and meanwhile inhibits the local bacteria. Upon treatments, the system generates amorphous MCPC with ultrasmall size (1–2 nm); then they enter the deep dentinal tubules, subsequently aggregate and crystalline into immobile larger particles, which finally seal the exposed dentinal tubules. The effective occlusion of dentinal tubules as well as significant antibacterial performance are confirmed both in vivo and in vitro. This study has devised not only a regulatory approach for the evolution of mineralization‐active clusters but also established an efficient method for managing dentin hypersensitivity.
Mechanosensitive and pH‐Gated Butterfly‐Shaped Artificial Ion Channel for High‐Selective K+ Transport and Cancer Cell Apoptosis
Authors: Wu Yaqi , Xu Qiangqiang , Chen Yaoxuan , Li Cong , Wu Yanliang , Yu Xiaoxuan , Li Hui , Xu Zhengwei , Xu Jiayun , Ni Zhigang , Ge Yan , Yan Tengfei , Qi Zhenhui , Liu Junqiu 
Published: February 2025

AbstractTo advance the exploration of mechanisms underlying natural multi‐gated ion channels, a novel butterfly‐shaped biomimetic K+ channel GnC7 (n = 3, 4) is developed with dual mechanical and pH responsiveness, exhibiting unprecedented K+/Na+ selectivity (G3C7: 34.4; G4C7: 41.3). These channels constructed from poly(propylene imine) dendrimer and benzo‐21‐crown‐7‐ethers achieve high K+ transport activity (EC50: 0.72 µm for G3C7; 0.9 µm for G4C7) due to their arc‐like mechanical rotation. The dynamic mode relies on butterfly‐shaped topology derived from the highly symmetrical core and multiple intramolecular hydrogen bonds. GnC7 can sense mechanical stimulus applied to liposomes/cells and then adapt the K+ transport rate accordingly. Furthermore, reversible ON/OFF switching of K+ transport is realized through the pH‐controllable host‐guest complexation. G4C7‐induced ultrafast cellular K+ efflux (70% within only 9 min) efficiently triggers mitochondrial‐dependent apoptosis of cancer cells by provoking endoplasmic reticulum stress accompanied by drastic Ca2+ sparks. This work embodies a multi‐dimensional regulation of channel functions; it will provide insights into the dynamic behaviors of biological analogs and promote the innovative design of artificial ion channels and therapeutic agents.
Recent Advances in Narrow Emission Bandwidth Materials for Application in Organic Light‐Emitting Diodes
Authors: Kang Jihoon , Shin Dong Jin , Lee Jun Yeob 
Published: February 2025

AbstractThe preparation of narrow emission bandwidth materials is crucial for the development of advanced organic light‐emitting diodes (OLEDs). In this review article, state‐of‐the‐art methodologies used for the preparation of narrow bandwidth emitters with high color purity are summarized, and favorable design strategies are rationally organized. Currently used OLEDs have some issues, such as device stabilization that must be resolved, and color purity should also be considered. Given the recent exponential growth in the number and types of narrowband emissive organic emitters and organometallic complexes exhibiting multiple‐resonance thermally activated delayed fluorescence and metal‐to‐ligand charge transfer characteristics, there is an urgent need to establish key technology descriptors for OLEDs with high color purity. In this review, recent developments in boron, fused indolocarbazole, carbonyl, phosphine oxide, and organometallic complexes that exhibit narrow emission spectra are described, and future directions to advance the performance of such devices are suggested.
Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease
Authors: Dagay Andrew , Katzav Shlomit , Wasserman Danielle , Gnoni Valentina , Mirelman Anat , Tauman Riva 
Published: February 2025

ObjectiveThe objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.MethodsIn this cross‐sectional exploratory study, participants underwent clinical, cognitive, and motor evaluation to compute risk based on the Movement Disorder Society (MDS) prodromal criteria and a standard overnight polysomnography. CAP rate, CAP index, A index subtypes, number of CAP sequences, and CAP sequence duration were computed from the electroencephalogram (EEG) signal.ResultsThe study included 30 patients with early PD (mean age = 62.80 ± 7.69, disease duration = 1.10 ± 1.09), 26 participants at risk for PD (age = 64.88 ± 10.09), and 36 participants with low risk for PD (age = 56.83 ± 7.41). Despite comparable macrosleep architecture, most CAP measures were significantly lower in patients with PD compared with the low‐risk group, whereas the at‐risk group showed transitional values between PD and the low‐risk group. The A2 index was significantly lower in both the at‐risk and PD groups from the low‐risk group (at risk = 7.59 ± 4.59; PD = 7.71 ± 5.83; and low risk = 12.85 ± 8.63; p = 0.010). Lower CAP rate and lower CAP index were associated with greater disease severity (r = −0.23 and − 0.24, respectively).InterpretationPatients with early clinical PD exhibit alterations in CAP dynamics despite having comparable macrosleep architecture. Alterations of the NREM microsleep structure may occur early in the neurodegenerative process and the A2 index may be an early event in the evolution of the disease with the potential to serve as an early marker for disease progression. ANN NEUROL 2025
‘Aiming for Integration’—Acculturation Strategies Among Refugee Youth in Sweden: A Qualitative Study Using a Resilience Framework
Authors: Giles Clover Jack , Västhagen Maja , Enebrink Pia , Ghaderi Ata , Oppedal Brit , Khan Sammyh 
Published: February 2025

ABSTRACTIn 2022, one in 20 minors in Sweden had a refugee background. As most refugees do not return to their countries of origin, understanding successful resettlement should be prioritised. Acculturation and psychological resilience are useful concepts, as both acknowledge the interplay between individual and contextual factors in sociocultural adjustment. However, less is known about the role of resilience in the selection and maintenance of acculturation strategies, especially among refugee youth. This qualitative interview study aimed to investigate how acculturation strategies may be shaped by risks and resources using a socioecological resilience framework. The narratives of 22 refugee youth in Sweden were explored using reflexive thematic analysis. Deductive coding, informed by an established socioecological model of immigrant youth adaptation, examined the interplay between individual acculturation motivations and contextual factors. The analysis resulted in six themes: (1) war, peace, and opportunities (global forces); (2) (dis)orientation and comparisons (socio‐political context); (3) aiming for integration (individual/motivation to acculturate); (4) learning to belong (microsystem—school); (5) inclusion and exclusion (microsystem—friends); (6) support, conflict, and accord (microsystem—family). The analysis highlights how resilience resources may enable maintenance, while frustration and discrimination can pose a risk to the maintenance of a preferred integration strategy.
Phytochemical Analysis, Cytotoxic Evaluation, and In Silico Screening of Metabolites from Dysoxylum malabaricum Bedd.
Authors: Bhardwaj Nivedita , Tripathi Nancy , Trivedi Rimjhim , Kumar Dinesh , Ravikanth Gudasalamani , Jain Shreyans Kumar 
Published: February 2025

Dysoxylum malabaricum is well‐known as a folklore herb. It is extensively utilized in traditional medicine to address various ailments. The study investigated the phytochemicals of D.malabaricum, focusing on its fruit, which was found to contain various terpenoids. Through extensive spectral analysis, 6 triterpenoids and 1 limonoid were identified and reported for the first time. The cytotoxicity of the compound was evaluated through in‐vitro and in‐silico studies followed by MD simulations. Extracts were prepared and chromatographic techniques were applied to isolate compounds from the extract, which underwent phytochemical screening via LC‐HRMS. Functional groups were assessed using NMR confirming the presence of bioactive compounds. HR‐LCMS analysis identified 7 phytoconstituents, with binectarilactone and dihydrobinectarilactone being potential bioactive characterized. Our findings confirm known molecules, highlighting the potential of binectarilactone and dihydrobinectarilactone as significant cytotoxic agents having IC50 of 29 µM and 14 µM, respectively, against MCF‐7 cell lines. The molecular docking and dynamic simulation analysis showed the anti‐cancer properties of the compound with EGFR enzymes. Binectarilactone and Dihydrobinectarilactone displayed the highest binding energy for all the proteins viz EGFR, FGFR, HER‐2, and IGFR‐1 overexpressed on MCF‐7, MDA‐MB‐231, Hs578t, ZR‐75‐30, BT549 cell lines. Both showed conformational stability of protein‐ligand complex with EGFR, FGFR and HER‐2.