bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation therapy and clinical outcomes following transcatheter mitral valve repair for patients with mitral regurgitation: A meta‐analysis
Authors: Zhang Jian , Yang Yu , Jia Lin , Su Jiannan , Xiao Ai , Lin Xianhe 
Published: April 2023

AbstractTranscatheter mitral valve repair (TMVR) using MitraClip (MC) is now an established technique in the interventional treatment of mitral regurgitation. Common complications after MC procedure are bleeding and ischemic events. However, 2017 ESC/EACTS and 2020 ACC/AHA did not give a clear antithrombotic protocol, the policy has been based on clinical experience. Here, we performed a meta‐analysis comparing outcomes with and without the addition of anticoagulants after TMVR. We searched the Cochrane Library, EMBASE, PubMed, and Web of Science from inception to October 6, 2022 to identify studies with or without the use of anticoagulants after TMVR. From each study, we extracted the number of people with bleeding, stroke, combined endpoints, and all‐cause death. Five observational cohort studies were included, enrolling a total of 1892 patients undergoing TMVR who were assigned to either the anticoagulation group (n = 1209) or the no‐anticoagulation group (n = 683). Pooled analysis showed a significantly lower stroke rate in the anticoagulated group (at least 4 weeks duration) compared with the non‐anticoagulated group (RR [95% CI] = 0.14 [0.0−0.77], p = 0.02), and similar rates of bleeding, combined endpoints, and all‐cause death in both groups (RR [95% CI] = 0.76 [0.48−1.22], p = 0.26), (RR [95% CI] = 0.52 [0.10−2.63], p = 0.43), and (RR [95% CI] = 0.89 [0.58−1.35], p = 0.58). We observed a reduced risk of stroke without elevated risk of bleeding, combined endpoints, or all‐cause death in patients using anticoagulants (at least 4 weeks duration) after TMVR compared to no anticoagulants.
Evidence for intraflagellar transport in butterfly spermatocyte cilia
Authors: Gottardo Marco , Riparbelli Maria Giovanna , Callaini Giuliano , Megraw Timothy L. 
Published: April 2023

AbstractIn the model organism insect Drosophila melanogaster short cilia assemble on spermatocytes that elaborate into 1.8 mm long flagella during spermatid differentiation. A unique feature of these cilia/flagella is their lack of dependence on intraflagellar transport (IFT) for their assembly. Here, we show that in the common butterfly Pieris brassicae, the spermatocyte cilia are exceptionally long: about 40 μm compared to less than 1 μm in Drosophila. By transmission electron microscopy, we show that P. brassicae spermatocytes display several features not found in melanogaster, including compelling evidence of IFT structures and features of motile cilia.
Generation of recombinant and chickenized scFv versions of an anti‐kinesin monoclonal antibody H2
Authors: Niwa Shinsuke , Chiba Kyoko 
Published: April 2023

AbstractKinesin‐1, a motor protein composed of the kinesin heavy chain (KHC) and the kinesin light chain (KLC), is essential for proper cellular morphogenesis and function. A monoclonal antibody (mAb) called H2 recognizes the KHC in a broad range of species and is one of the most widely used mAbs in cytoskeletal motor research. Here, we present vectors that express recombinant H2 in mammalian cells. We show the recombinant H2 performs as well as the hybridoma‐derived H2 in both western blotting and immunofluorescence assays. Additionally, the recombinant H2 can detect all three human KHC isotypes (KIF5A, KIF5B, and KIF5C) and amyotrophic lateral sclerosis‐associated KIF5A aggregates in cells. In addition, we developed a chickenized version of the H2 mAb's single chain variable fragment, which can be used in immunofluorescence microscopy and expands the potential applications of H2. Overall, our results demonstrate that recombinant H2 is a useful tool for studying the functions of KHCs.
Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study
Authors: D’Souza Gypsyamber , Tewari Sakshi R. , Troy Tanya , Waterboer Tim , Struijk Linda , Castillo Rachel , Wright Hannah , Shen Michael , Miles Brett , Johansson Mattias , Robbins Hilary A. , Fakhry Carole 
Published: April 2023

AbstractBackgroundHuman papillomavirus (HPV)‐related oropharyngeal cancer screening is being explored in research studies, but strategies to identify an appropriate population are not established. The authors evaluated whether a screening population could be enriched for participants with oncogenic HPV biomarkers using risk factors for oral HPV.MethodsParticipants were enrolled at Johns Hopkins Hospitals and Mount Sinai Icahn School of Medicine. Eligible participants were either men aged 30 years or older who had two or more lifetime oral sex partners and a personal history of anogenital dysplasia/cancer or partners of patients who had HPV‐related cancer. Oral rinse and serum samples were tested for oncogenic HPV DNA, RNA, and E6 or E7 antibodies, respectively. Participants with any biomarker were considered at‐risk.ResultsOf 1108 individuals, 7.3% had any oncogenic oral HPV DNA, and 22.9% had serum antibodies for oncogenic HPV E6 or E7. Seventeen participants (1.5%) had both oral and blood biomarkers. HPV type 16 (HPV16) biomarkers were rarer, detected in 3.7% of participants, including 20 with oral HPV16 DNA and 22 with HPV16 E6 serum antibodies (n = 1 had both). In adjusted analysis, living with HIV (adjusted odds ratio, 2.65; 95% CI, 1.60–4.40) and older age (66–86 vs. 24–45 years; adjusted odds ratio, 1.70; 95% CI, 1.07–2.70) were significant predictors of being at risk. Compared with the general population, the prevalence of oral HPV16 (1.8% vs. 0.9%), any oncogenic oral HPV DNA (7.3% vs. 3.5%), and HPV16 E6 antibodies (2.2% vs. 0.3%) was significantly elevated.ConclusionsEnrichment by the eligibility criteria successfully identified a population with higher biomarker prevalence, including HPV16 biomarkers, that may be considered for screening trials. Most in this group are still expected to have a low risk of oropharyngeal cancer.
Cannabis use among cancer survivors in 22 states: Results from the Behavioral Risk Factor Surveillance System, 2020
Authors: Sedani Ami E. , Campbell Janis E. , Beebe Laura A. 
Published: April 2023

AbstractBackgroundThis study identified factors associated with recent cannabis use and cannabis use for medical purposes among cancer survivors relative to individuals without a history of cancer.MethodsData from the Behavioral Risk Factor Surveillance System were analyzed for the 22 states completing the optional cannabis module in 2020. Weighted multiple logistic regression was performed to explore variables associated with past 30‐day cannabis use and cannabis use for medical purposes, stratified by history of cancer. Covariates included state‐level cannabis policy, sociodemographic characteristics, health status indicators, and substance use.ResultsCannabis use was lower among cancer survivors compared to individuals with no history of cancer (7.57% vs. 10.83%). However, a higher proportion of cancer survivors reported use for medical purposes (82.23% vs. 62.58%). After adjusting for state‐level policy, biological sex, age, educational attainment, self‐reported race/ethnicity, home ownership, mental health status and physical health status, current smoking (odds ratio [OR], 5.14 vs. 3.74) and binge drinking (OR, 2.71 vs. 2.69) were associated with cannabis use in both groups. Characteristics associated with medical cannabis use varied for the two groups; however, daily use (20–30 days; OR, 1.72 vs. 2.43) was associated with cannabis use for medical purposes in both groups after adjusting for other variables in the model.ConclusionsA high proportion of individuals report cannabis use for medical purposes with higher rates among cancer survivors. Findings support the urgent need for ongoing cannabis research to better understand and inform its use for medical purposes, as well as the development of high‐quality standardized education materials and clinical practice guidelines.
Emocolor: An assistant design method for emotional color matching based on semantics and images
Authors: Zhang Lekai , Li Ming , Wang Yingfan , Xing Baixi , Liu Xiaojian , Tang Zhichuan , Shi Lei 
Published: April 2023

AbstractMuch research has been done on the relationship between emotions and colors, and many color scheme recommendation tools have been developed. These tools can often help recommend a suitable color scheme to express a certain emotion, but it is still difficult to design satisfying schemes based on such recommendations. In this study, based on the Color Scheme Bible, Compact Edition, we developed Emocolor, which allows professionals to generate a large number of color schemes based on emotional words or emotional images. It is also used to iteratively optimize the generated color schemes based on an interactive genetic algorithm to find the color scheme design that best matches the user's emotion. Through the evaluation of tram color schemes based on emotional words, Emocolor can effectively generate tram color schemes that match users’ emotions. It can also effectively transfer the emotion of an image with a single dominant color to a tram color scheme. In short, Emocolor can help professionals describe the relationship between emotion and color in a more accurate way and design emotional color schemes. Emocolor can be applied in advertising design, product design, interior design, and other fields.
Pharmacokinetics and Bioequivalence of Fluconazole Capsules Manufactured in France and China in Healthy Chinese Participants: Open‐Label, Randomized, Single‐Dose, 2‐Way, Crossover Bioequivalence Study Under Fasted and Fed Conditions
Authors: Chen Naihan , He Qing , Ma Ying , Liu Shixue , Wei Hua , Peng Ao 
Published: April 2023

AbstractThis was an open‐label, randomized study in healthy Chinese participants to assess the bioequivalence of 2 fluconazole 150‐mg capsules under fasted and fed conditions. The study consisted of 2 treatment periods, separated by a 14‐day washout period. Thirty‐six participants were enrolled, with 18 participants each in the fasted and fed groups. In each treatment period, participants received a single oral dose of the test or reference fluconazole 150‐mg capsule. After washout, participants received the alternate treatment. Blood samples for pharmacokinetic analysis were collected from 1 hour before dosing to 72 hours after dosing. The median plasma concentration–time profiles were similar for both treatments under fasted and fed conditions. Bioequivalence of fluconazole between the 2 capsules was demonstrated as 90% confidence intervals of the geometric mean ratios for the maximum plasma concentration and area under the plasma concentration–time curve from time 0 to 72 hours after dosing under fasted and fed conditions were within the acceptable range of 80%–125%. Overall, 7 participants reported at least 1 treatment‐emergent adverse event; all were mild in severity. No serious adverse events or deaths were reported. The test fluconazole capsule was bioequivalent to the reference capsule, and a single dose was well tolerated.Clinicaltrials.gov ID: NCT03621072
Accurate Interaction Energies of CO2 with the 20 Naturally Occurring Amino Acids
Authors: Sylvanus Amarachi G. , Vogiatzis Konstantinos D. 
Published: April 2023

AbstractWe have performed a series of highly accurate calculations between CO2 and the 20 naturally occurring amino acids for the investigation of the attractive noncovalent interactions. Different nucleophilic groups present in the amino acid structures were considered (α‐NH2, COOH, side groups), and the stronger binding sites were identified. A database of accurate reference interactions energies was compiled as computed by explicitly‐correlated coupled‐cluster singles‐and‐doubles, together with perturbative triples extrapolated to the complete‐basis‐set limit. The CCSD(F12)(T)/CBS reference values were used for comparing a variety of popular density functionals with different basis sets. Our results show that most density functionals with the triple‐zeta basis set def2‐TZVPP align with the CCSD(F12)(T)/CBS reference values, but errors range from 0.1 kcal/mol up to 1.0 kcal/mol.
Theoretical Design of an MoxW1‐xS2/Graphene (x=0.25/0.75) Heterojunction with Adjustable Band Gap: Potential Candidate Materials for the Next Generation of Optoelectronic Devices
Authors: Chen Jinglong , Zhou Zhonghao , Li Zhi , Wang Zhiyong 
Published: April 2023

AbstractMulticomponent two‐dimensional (2D) transition metal dichalcogenides (TMDCs) semiconductors based on adjustable band gap are increasingly used to design optoelectronic devices with specific spectral response. Here, we have designed the MoxW1‐xS2/graphene heterostructure with adjustable band gap by adopting the combination idea of alloying and multiple heterogeneous recombination. The contact type, stability and photoelectric properties of MoxW1‐xS2/graphene heterojunction were investigated theoretically. At the same time, by applying external vertical electric field to MoxW1‐xS2/graphene, the regulate of heterojunction Schottky contact type was realized. The results show that MoxW1‐xS2/graphene heterojunction has broad application prospects in the field of photocatalysis and Schottky devices, and is suitable for being a potential candidate material for next generation of optoelectronic devices. The design of MoxW1‐xS2/graphene heterostructure enables it to obtain the advanced characteristics that are lacking in the one‐component intrinsic 2D TMDCs semiconductors or graphene materials, and provides a theoretical basis for the experimental preparation of such heterojunctions.
Clinical Untargeted Metabolomics as a Functional Screen to Improve Variant Classification
Authors: Gijavanekar Charul , Elsea Sarah H. 
Published: April 2023

AbstractWith the rapid increase in clinical exome and genome sequencing, the number of variants of uncertain significance (VUS) that are reported continues to rise, which poses a significant barrier to interpretation of genetic findings. For metabolic disorders, biochemical testing can help alleviate this burden of variant interpretation by providing functional validation of uncertain genetic findings in many cases. However, a major limitation of traditional biochemical testing is the targeted, narrow range of analytes clinically available, resulting in delays in diagnosis if testing is negative. Untargeted metabolomic screening offers higher diagnostic yield and assays for thousands of metabolites across multiple metabolic pathways in a single test, saving time and resources for patients, families, and physicians. When integrated with exome or genome sequencing, untargeted metabolomic screening improves diagnostic outcomes by providing functional validation of genetic findings, particularly for VUS. Here, we present representative cases across the breadth of metabolic pathways as examples of the utility of metabolomics in genomic variant classification. © 2023 Wiley Periodicals LLC.
Investigation of Crystallization Kinetics of Na2ZnP2O7 Glass Using XRD and DTA Analysis
Authors: Ramdani Halima , Bourezg Yousf Islem , Kharroubi Mohamed , Sahnoune Foudil , Gacem Lakhdar 
Published: April 2023

AbstractIn the present investigation, the crystallization kinetics of a glass with a molar composition 25Na2O‐25ZnO‐50P2O5 (NZPO) is studied by means of a non‐isothermal differential thermal analysis (DTA) and X‐ray diffraction (XRD) techniques. XRD pattern of the as‐synthesized glass indicates an amorphous glassy structure without additional crystalline phase. Moreover, the heat‐treated glass sample shows the crystallization of the Na2ZnP2O7 crystalline phase. The glass transition peak temperature increases with increasing heating rates and is ranged from 505.3 to 601.6 K. The crystallization shows the same behavior and the obtained values are ranged from 685.2 to 731.2 K. The activation energies for glass transition and crystallization are determined using different approaches and are in the range of 25.9–30.5 and 82.8–112.0 kJ mol−1, respectively. The n and m kinetic parameters are each close to 3.0, which indicates bulk nucleation process with 3D growth of crystals.
Predictors of recovery in eating disorders: A focus on different definitions
Authors: van Bree Eline S. J. , Slof‐Op't Landt Margarita C. T. , van Furth Eric F. 
Published: April 2023

AbstractObjectiveOnly half of the patients with eating disorders (EDs) fully recover. To increase these rates, knowledge about predictors is essential. Previous studies found that purging behaviors, BMI, ED duration, and depression, predicted symptomatic ED recovery. The current study investigated these four predictors for symptomatic improvement and the subjective experience of recovery.MethodParticipants who completed the baseline and second wave of the Netherlands Eating disorder Registry (NER) (N = 374), were categorized into: (1) Subjective recovery; (2) Clinical improvement; (3) Symptomatic recovery. Using regression analyses, it was investigated if the four baseline factors predicted recovery at wave two. Effects were compared among a binge‐purging and restricting group.ResultsIn total, 136 participants were subjectively recovered, 135 showed clinical improvement, and 70 were symptomatically recovered. Overlap occurred between definitions. Lower depression scores predicted subjective recovery (OR 0.77, p < .001) and clinical improvement (OR 0.80, p < .001), and shorter ED duration predicted all definitions (OR 0.99, p < .001; OR 0.99, p < .001; OR 0.99, p = .013). Similar effects were found in the binge‐purging group.DiscussionOur study emphasized that the same predictors, like depression, apply to symptomatic improvement and the personal experience of recovery. Depression appears an important factor during ED treatment.Public significanceRecovery rates for EDs are low. To understand this, knowledge about predictors of ED recovery is essential. This study examined the effects of four established predictors across symptomatic improvement and subjective recovery (a more personal experience of recovery). Lower depression scores predicted both, indicating that depression appears important for multiple definitions of recovery and therefore warrants attention during ED treatment.
Measuring habitat quality for waterbirds: A review
Authors: Mott Rowan , Prowse Thomas A. A. , Jackson Micha V. , Rogers Daniel J. , O'Connor Jody A. , Brookes Justin D. , Cassey Phillip 
Published: April 2023

AbstractQuantifying habitat quality is dependent on measuring a site's relative contribution to population growth rate. This is challenging for studies of waterbirds, whose high mobility can decouple demographic rates from local habitat conditions and make sustained monitoring of individuals near‐impossible. To overcome these challenges, biologists have used many direct and indirect proxies of waterbird habitat quality. However, consensus on what methods are most appropriate for a given scenario is lacking. We undertook a structured literature review of the methods used to quantify waterbird habitat quality, and provide a synthesis of the context‐dependent strengths and limitations of those methods. Our search of the Web of Science and Scopus databases returned a sample of 666 studies, upon which our review was based. The reviewed studies assessed habitat quality by either measuring habitat attributes (e.g., food abundance, water quality, vegetation structure), or measuring attributes of the waterbirds themselves (e.g., demographic parameters, body condition, behavior, distribution). Measuring habitat attributes, although they are only indirectly related to demographic rates, has the advantage of being unaffected by waterbird behavioral stochasticity. Conversely, waterbird‐derived measures (e.g., body condition, peck rates) may be more directly related to demographic rates than habitat variables, but may be subject to greater stochastic variation (e.g., behavioral change due to presence of conspecifics). Therefore, caution is needed to ensure that the measured variable does influence waterbird demographic rates. This assumption was usually based on ecological theory rather than empirical evidence. Our review highlighted that there is no single best, universally applicable method to quantify waterbird habitat quality. Individual project specifics (e.g., time frame, spatial scale, funding) will influence the choice of variables measured. Where possible, practitioners should measure variables most directly related to demographic rates. Generally, measuring multiple variables yields a better chance of accurately capturing the relationship between habitat characteristics and demographic rates.
Landscape factors and allochthonous congeneric species influenceCallithrix auritaoccurrence in Brazilian Atlantic Forest remnants
Authors: Loureiro Natasha Grosch , Guimarães‐Lopes Vanessa de Paula , Rodrigues Flávio Henrique Guimarães , Massara Rodrigo Lima 
Published: April 2023

AbstractThe buffy‐tufted‐ear marmoset (Callithrix aurita) is a small primate endemic to the Brazilian Atlantic Forest biome, and one of the 25 most endangered primates in the world, due to fragmentation, loss of habitat, and invasion by allochthonousCallithrixspecies. Using occurrence data forC. auritafrom published data papers, we employed model selection using Akaike Information Criterion corrected for small samples and cumulative AICc weight (w+) to evaluate whether fragment size, distance to fragments with allochthonous species, altitude, connectivity, and surrounding matrices influence the occurrence ofC. auritawithin its distributional range. Distance to fragments withC. jacchus(w+ = 0.94) and nonvegetated areas (w+ = 0.59) correlated negatively withC. auritaoccurrence. Conversely, the percentage of agriculture and pasture mosaic (w+ = 0.61) and the percentage of savanna formation (w+ = 0.59) in the surrounding matrix correlated positively withC. auritaoccurrence. The findings indicate thatC. auritais isolated in forest fragments surrounded by potentially inhospitable matrices, along with proximity of a more generalist and invasive species, thereby increasing the possibility of introgressive hybridization. The findings also highlighted the importance of landscape elements and allochthonous congeneric species forC. auritaconservation, besides indicating urgency for allochthonous species management. Finally, the approach used here can be applied to improve conservation studies of other endangered species, such asC. flaviceps, which is also endemic to the Brazilian Atlantic Forest and faces the same challenges.