bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Herpes simplex virus and Vesicular stomatitis virus Proliferation byLactiplantibacillus planterumand star anise Extract Is Associated with Induction ofMXgene expression
Authors: Elebeedy Dalia , Abdelgeliel Asmaa Sayed , Ghanem Aml , Badawy Ingy , Sajer Bayan H. , Redhwan Alya , Alghamdi Mashail A , Eletmany Mohamed R. , El-Sayed Marwa 
Published: January 2023

AbstractPurposeThere is an immense need to develop new antiviral compounds that are effective and have little side effects. Natural compounds provide a good candidate that is gaining popularity. Probiotics asLactiplantibacillus plantarumand plant-derived medicines as star anise extract have been investigated to treat viral diseases, cancer, and inflammation. This work aimed to investigate the antiviral effect of probiotics (Lactiplantibacillus plantarum) and (star anise) against Herpes simplex virus type 1(HSV-1) and Vesicular stomatitis virus (VSV).Patients and methodsLactiplantibacillus plantarumand star anise extract had been prepared and tested against vero cell lines for cytotoxicity assay. The antiviral effect ofL. plantarumand star anise against HSV-1 and VSV was evaluated by titration calculation (TCID50). The expression ofMXgenes were measured in infected cells before and after treatment withL. plantarumand star anise.ResultsWe found thatL. planterumis more effective againstHSV-1and caused 2.5 log reduction in virus titre while star anise extract is more effective against VSV and caused 1.25 log reduction in virus titre. Evaluation ofMXgenes expression revealed higher expression in HSV-1 infected cell treated withL. planterumand VSV infected cells treated with star anise extract.ConclusionL. planterumand star anise could be useful antiviral natural compounds that have minimal side effectsPlain language SummaryBoth Herpes simplex virus type 1(HSV-1) and Vesicular stomatitis virus (VSV) caused infection characterized by lytic lesions.Lactiplantibacillus plantarumand star anise had shown promising antiviral effects. So, we investigated the antiproliferative effect ofL. plantarumand star anise against HSV-1 and VSV by assessment of virus titre before and after treatment and assessment ofMXgene coding for antiviral proteins. We found thatL. plantarumand star anise could inhibit proliferation of HSV-1 and VSV and increase expression ofMXgene.L. plantarumand star anise could be good antiviral candidate.
A Scoping Review of Factors used to Explain Disparities in COVID-19 Vaccination Intentions and Uptake among People of Color—United States, December 1, 2020-April 30, 2021
Authors: Wilson Rebecca F. , Kota Krishna Kiran , Sheats Kameron J. , Luna-Pinto Carolina , Owens Chantelle , Harrison Dominique D. , Razi Sima 
Published: January 2023

ABSTRACTBackgroundVaccine access, coupled with the belief that vaccines are important, beneficial, and safe, plays a pivotal role in achieving high levels of vaccination to reduce the spread and severity of COVID-19 in the United States (U.S.) and globally. Many factors can influence vaccine intentions and uptake.MethodsWe conducted a scoping review of factors (e.g., access-related factors, racism) known to influence vaccine intentions and uptake, using publications from various databases and websites published December 1, 2020-April 30, 2021. Descriptive statistics were used to present results.ResultsOverall, 1094 publications were identified through the database search, of which 133 were included in this review. Among the publications included, over 60% included mistrust in vaccines and vaccine-safety concerns, 43% included racism/discrimination, 35% included lack of vaccine access (35%), and 8% had no contextual factors when reporting on vaccine intentions and disparities in vaccine uptake.ConclusionsFindings revealed during a critical period when there was a well-defined goal for adult COVID-19 vaccination in the U.S., some publications included several contextual factors while others provided limited or no contextual factors when reporting on disparities in vaccine intentions and uptake. Failing to contextualize inequities and other factors that influence vaccine intentions and uptake might be perceived as placing responsibility for vaccination status on the individual, consequently, leaving social and structural inequities that impact vaccination rates and vaccine confidence, among people of color, intact.
Relationships between leadership and culture, human resources and process improvement in lean healthcare
Authors: Vanichchinchai Assadej 
Published: January 2023

PurposeThis research aims to examine the relationships among leadership and culture, human resources and process improvement in lean hospitals from the socio-technical perspective.Design/methodology/approachThe survey instrument was developed from literature reviews, verified by experts and confirmatory factor analysis. Multiple responses were used to collect data from 473 care providers in 220 outpatient departments of Thai hospitals to improve reliability of the obtained data. Path analysis of structural equation modeling was applied to analyze the hypotheses.FindingsIt was found that human resources has a significant positive direct effect on process improvement. Leadership and culture not only has significant direct positive impacts on human resources and process improvement but also has a significant indirect positive impact on process improvement through human resources.Originality/valueThis is one of the first examples of research to present insights into the links between soft and hard factors of lean hospitals at strategic and operational levels.
Robotic life of casino employees: exploring well-being dimensions in the gambling industry in Malaysia
Authors: Chaichi Kamelia , Trupp Alexander , Ranjanthran Mageswari , Thirumaran K. 
Published: January 2023

PurposeEmployee well-being in a casino work environment is crucial for the quality of work-life and employees' performance. This study examines the dimensions of well-being at a casino in Malaysia to gain deeper insights into employee challenges and motivational factors to arrive at practical mitigation efforts.Design/methodology/approachThe study adopted a qualitative approach involving 14 semi-structured interviews with casino employees in Malaysia. Interviews lasted 30 min to 2 h at a time when Covid-19 was raging in 2021. Responses were analysed via a data-driven approach and coded using NVivo software to delineate the contents into analytical categories of well-being dimensions.FindingsThe findings suggest that employees at the casino face challenges in achieving work-life balance. Employee's well-being suffers from insufficient break time, irregular working hours affecting family time, managing customer temper tantrums and lack of emotional support systems and remunerations altered by the pandemic. Women employees were particularly vulnerable.Research limitations/implicationsThe findings suggest a need to create better working conditions and address well-being with counselling support for stress management, a balanced approach by employers to the “customer is always right” mantra, creating promising career pathways and supervisors to have better oversight of workaholics. The research focused only on one casino and there was limited access to management departments for an organizational perspective.Originality/valueThis study adds to the body of knowledge on employee well-being in the context of a casino. It suggests hospitality and tourism organizations review their human resource practices that would ease the stresses at the workplace and create support systems to promote employee well-being. Crucially, in a pandemic crisis, well-being dimensions must be accommodating and integrative to employee sentiments, sensitivity and self-actualization.
Sociomaterial influence on social media: exploring sexualised practices of influencers on Instagram
Authors: Bussy-Socrate Hélène , Sokolova Karina 
Published: January 2023

PurposeRelying on social influence and sociomateriality theories, this research provides new insights about the social and material drivers relating to the sexualisation of online behaviour of social media influencers.Design/methodology/approachUsing a netnographic approach, observation data were gathered from the Instagram accounts of 20 influencers dedicated to beauty and fashion. In addition, 15 in-depth interviews were conducted with women adopting sexualisation practices online. The data were analysed using an abductive strategy; all materials were coded according to thematic analysis principles.FindingsThe authors observe that sexualisation is a result of a complex system of social interactions encouraged and reinforced by multiple factors and actors. In particular, the authors outline the major influence of technology that has become a non-human authority defining implicit norms and shaping the beliefs and behaviours of women influencers.Originality/valueIn contrast to existing literature which mainly focuses on the negative consequences of sexualisation, this work sheds some light on social constructs in social media. The authors contribute to the growing literature on social media influencers. Although many works focus on their persuasiveness, this work helps to better understand the social setting, motivations and pressures that are contained in social and technological contexts.
The role of synergistic interplay among LMX, leader creativity expectations and job characteristics in stimulating creative process engagement
Authors: Liu He , Xu Feng , Wu Chong 
Published: January 2023

PurposeAs a typical creative behavior, creative process engagement (CPE) has received increased attention in recent years. Leadership behaviors such as leader–member exchange (LMX) and leader creativity expectations (LCE) have been found as two key predictive factors of CPE. However, the mechanism underlying this relationship is not well understood. This study aims to clarify how LMX influences follower CPE by considering the interplay among LCE, decision autonomy and task interdependence from an interactionist perspective.Design/methodology/approachUsing a sample of 371 leader–employee dyads from eight enterprises in mainland China, this study conducts a hierarchical regression analysis to test the hypotheses for the proposed model.FindingsResults reveal that the significant two- and three-way interactions where LCE, decision autonomy and task interdependence moderate the relationship between LMX and follower CPE. The relationship between LMX and follower CPE is not significant as expected, but the moderating role of LCE is positive and significant, and the relationship is strongest when conducted with either low task interdependence or high decision autonomy.Originality/valueDifferent from previous research that only investigated one certain leadership factor’ effect on employees' innovative behaviors, this study comprehensively considered the combined influence of two related but significantly different connotation leadership factors on follower CPE and found the contingency effect of LCE on the relationship between LMX and follower CPE. Furthermore, the authors found the regional effectiveness of the leadership factor. The effect of leadership factors on follower CPE varies under the influence of different job characteristics, and is conducive to enrich the interactionist view on follower CPE.
Introduction of an emergency medicine pharmacist‐led sepsis alert response system in the emergency department: A cohort study
Authors: Roman Cristina Petronela , Dooley Michael , Nevill Alexandra , Szmidel Matthew , McGloughlin Steven , Luckhoff Carl , Mitra Biswadev 
Published: January 2023

AbstractObjectiveTo determine effects of implementing a sepsis alert response system in the ED that included early intervention by emergency medicine (EM) pharmacists.MethodsA prospective cohort (8 February 2016 to 28 February 2018) of patients after implementation of a sepsis alert response system in an Australian ED was compared to a retrospective cohort (3 January 2015 to 7 February 2016) of patients with sepsis who presented during EM pharmacist working hours and were admitted to the ICU.ResultsThere were 184 patients, including 80 patients pre‐ and 104 patients post‐implementation. The post‐intervention cohort was triaged at a higher acuity, had higher quick Sepsis‐related Organ Failure Assessment (qSOFA) scores and higher initial lactate measurements. After the intervention, antimicrobial agents were administered to patients within 60 min of presentation more often (21 [26.3%] to 85 [81.7%], P < 0.001). After adjusting for presenting triage category, admission lactate and presenting qSOFA scores, this association remained significant (adjusted odds ratio 9.99; 95% confidence interval 4.7–21.3). Significant improvements were observed for proportion of patients who had intravenous fluids initiated within 60 min (47.5% vs 72.1%); proportion of patients who had serum lactate measured within 60 min (50.0% vs 77.9%) and proportion of patients who had blood cultures performed within 60 min (52.5% vs 85.6%).ConclusionImplementation of a sepsis alert response that included early involvement of the EM pharmacist was associated with improvement in time to antimicrobials and other components of the sepsis bundle. An upfront, multidisciplinary approach to patients presenting to the ED with suspected sepsis should be considered more broadly.
Early infancy dysbiosis in food protein‐induced enterocolitis syndrome: A prospective cohort study
Authors: Su Kuan‐Wen , Cetinbas Murat , Martin Victoria M. , Virkud Yamini V. , Seay Hannah , Ndahayo Renata , Rosow Rachael , Elkort Michael , Gupta Brinda , Kramer Eileen , Pronchick Tetiana , Reuter Susan , Sadreyev Ruslan I. , Huang Jing‐Long , Shreffler Wayne G. , Yuan Qian 
Published: January 2023

AbstractBackgroundThe microbiome associations of food protein‐induced enterocolitis syndrome (FPIES) are understudied. We sought to prospectively define the clinical features of FPIES in a birth cohort, and investigate for the evidence of gut dysbiosis.MethodsWe identified children diagnosed with FPIES in the Gastrointestinal Microbiome and Allergic Proctocolitis Study, a healthy infant cohort. Children were assessed and stools were collected at each well child visit. The clinical features of the children with FPIES were summarized. Stool microbiome was analyzed using 16S rRNA sequencing comparing children with and without FPIES.ResultsOf the 874 children followed up for 3 years, 8 FPIES cases (4 male) were identified, yielding a cumulative incidence of 0.92%. The most common triggers were oat and rice (n = 3, each) followed by milk (n = 2). The children with FPIES were more likely to have family history of food allergy (50% vs. 15.9% among unaffected, p = .03). The average age of disease presentation was 6 months old. During the first 6 months of life, stool from children with FPIES contained significantly less Bifidobacterium adolescentis, but more pathobionts, including Bacteroides spp. (especially Bacteroides fragilis), Holdemania spp., Lachnobacterium spp., and Acinetobacter lwoffii. The short‐chain fatty acid (SCFA)‐producing Bifidobacterium shunt was expressed significantly less in the stool from FPIES children.ConclusionsIn this cohort, the cumulative incidence over the 3‐year study period was 0.92%. During the first 6 months of life, children with FPIES had evidence of dysbiosis and SCFA production pathway was expressed less in their stool, which may play an important role in the pathogenesis of FPIES.
Reversible pigs
Authors: Arregui Aníbal G. 
Published: January 2023

AbstractThe idea of “species” is the main unit for representing ecological relations. But what would an ecology look like if we started by tracing its relations from below the species threshold? By deploying an infraspecies ethnography, I show how, in suburban Barcelona, human and wild boar individuals relate in personal, creative ways, and how in doing so, they also reshape their quotidian ecologies from the bottom up. Departing from species‐level imaginaries of wildlife managers, suburban residents cope with wild boars not only as idiosyncratic specimens but also as reversible beings: pigs that are simultaneously “wild” and “tame,” “rural” and “urban,” “pest” and “neighbor.” Shifting the attention from relations between coherent species to the situated encounters between singular specimens unveils how individuals weave reversible relations, remake ecologies, and navigate the uncertainty of emerging human‐animal intimacies.
Attention‐deficit hyperactivity disorder is associated with relatively short stature among adolescents
Authors: Namimi‐Halevi Chen , Dor Chen , Dichtiar Rita , Bromberg Michal , Sinai Tali 
Published: January 2023

AbstractAimTo estimate the association between attention‐deficit hyperactivity disorder (ADHD) and relatively short stature (RSS) among adolescents.MethodsParticipants in the Israeli Youth Health and Nutrition Survey (2015–2016), a cross‐sectional school‐based study, completed self‐administered questionnaires and underwent anthropometric measurements. Height z‐score < −0.7 (<25th percentile) was defined as RSS. Multivariable logistic regression analyses assessed the relation between ADHD and RSS, controlling for age, sex, body mass index (BMI) and socioeconomic status (Basic Model), and also for lifestyle factors such as physical activity, sleep duration, dietary patterns and intakes.ResultsOf 4173 participants (11–18 years, 50.2% males), 654 self‐reported ever being diagnosed with ADHD; 3519 participants were controls. Overweight (BMI z‐score ≥1) and pubertal status were not different among groups. According to the Basic Model, ADHD was significantly associated with RSS (OR 1.25, 95% CI 1.03–1.50), and even after adjustments for lifestyle factors and dietary intake (OR 1.28, 95% CI 1.03–1.58). Stimulant‐treated ADHD adolescents had similar height z‐scores and lifestyles as those not treated with stimulants.ConclusionAttention‐deficit hyperactivity disorder was associated with RSS. Height deficit may be intrinsic to ADHD or its pharmacotherapy, rather than a consequence of lifestyle alone. Further studies are needed to determine the causal relationship between ADHD and short stature.
Impact of malnutrition and nutrition support in hospitalised patients with inflammatory bowel disease
Authors: Dua Anoushka , Corson Melissa , Sauk Jenny S. , Jaffe Nancee , Limketkai Berkeley N. 
Published: January 2023

SummaryBackgroundMalnutrition is prevalent in patients with inflammatory bowel disease (IBD) and has been associated with worse clinical outcomes.AimsThis observational study examines trends in protein‐calorie malnutrition (PCM) amongst hospitalised IBD and non‐IBD patients, and the association between (1) malnutrition and (2) nutrition support and hospitalisation outcomes.MethodsWe queried the Nationwide Readmissions Database from 2010 to 2018 for hospitalisations with and without IBD. Amongst patients with IBD and concurrent PCM, we identified those who received nutrition support. Multivariable Cox proportional hazards and Kaplan‐Meier analyses evaluated the associations between PCM and nutrition support and readmission and mortality. Multiple linear regression described the association between compared variables and length of stay (LOS) and total hospitalisation costs.ResultsThis study included 1,216,033 patients (1,820,023 hospitalisations) with Crohn's disease (CD), 832,931 patients (1,089,853 hospitalizations) with ulcerative colitis (UC) and 240,488,656 patients (321,220,427 hospitalisations) without IBD. Admitted IBD patients were 2.9–3.1 times more likely to have PCM than non‐IBD patients. IBD patients with PCM had a higher risk of readmission and mortality, as well as longer LOS and higher hospitalisation costs. Nutrition support (parenteral and enteral) was associated with a reduced risk of readmission, but higher mortality increased LOS and higher total hospitalisation costs.ConclusionsMalnutrition in hospitalised IBD patients remains an important contributor to readmission, mortality, LOS and healthcare costs. Providing nutrition support to IBD patients may reduce the risk of readmission. Further studies are needed to evaluate the role of nutrition support amongst hospitalised IBD patients to optimise disease and healthcare outcomes.
PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast
Authors: Zhi Renyong , Wu Kailiang , Zhang Jingyue , Liu Hanjiao , Niu Chen , Li Shuai , Fu Li 
Published: January 2023

AbstractInvasive micropapillary carcinoma (IMPC) is a special histopathological subtype of breast cancer. Clinically, IMPC exhibits a higher incidence of lymphovascular invasion and lymph node metastasis compared with that of invasive ductal carcinoma (IDC), the most common type. However, the metabolic characteristics and related mechanisms underlying malignant IMPC biological behaviors are unknown. We performed large‐scale targeted metabolomics analysis on resected tumors obtained from chemotherapy‐naïve IMPC (n = 25) and IDC (n = 26) patients to investigate metabolic alterations, and we integrated mass spectrometry analysis, RNA sequencing, and ChIP‐sequencing data to elucidate the potential molecular mechanisms. The metabolomics revealed distinct metabolic profiles between IMPC and IDC. For IMPC patients, the metabolomic profile was characterized by significantly high levels of arginine methylation marks, and protein arginine methyltransferase 3 (PRMT3) was identified as a critical regulator that catalyzed the formation of these arginine methylation marks. Notably, overexpression of PRMT3 was an independent risk factor for poor IMPC prognosis. Furthermore, we demonstrated that PRMT3 was a key regulator of breast cancer cell proliferation and metastasis both in vitro and in vivo, and treatment with a preclinical PRMT3 inhibitor decreased the xenograft tumorigenic capacity. Mechanistically, PRMT3 regulated the endoplasmic reticulum (ER) stress signaling pathway by facilitating histone H4 arginine 3 asymmetric dimethylation (H4R3me2a), which may endow breast cancer cells with great proliferative and metastatic capacity. Our findings highlight PRMT3 importance in regulating the malignant biological behavior of IMPC and suggest that small‐molecule inhibitors of PRMT3 activity might be promising breast cancer treatments.
Targeting soluble epoxide hydrolase promotes osteogenic–angiogenic coupling via activating SLIT3/HIF‐1α signalling pathway
Authors: Gao Lu , Chen Weixian , Li Lijun , Li Juanjuan , Kongling Wenyao , Zhang Yaoyang , Yang Xueping , Zhao Yanrong , Bai Jie , Wang Fu 
Published: January 2023

AbstractType H vessels have recently been identified to modulate osteogenesis. Epoxyeicostrioleic acids (EETs) have an essential contribution to vascular homeostasis. However, whether increased EETs with soluble epoxide hydrolase (sEH) inhibitor TPPU enhance the coupling of angiogenesis and osteogenesis remains largely unknown. The effects of TPPU on cross‐talk between co‐cultured human umbilical vein endothelial cells (HUVECs) and human dental pulp stem cells (hDPSCs), and on long bone growth and calvarial defect repair in mice were investigated in vitro and in vivo. TPPU enhanced osteogenic differentiation of co‐cultured HUVECs and hDPSCs in vitro and increased type H vessels, and long bone growth and bone repair of calvarial defect. Mechanistically, TPPU promoted cell proliferation and angiogenesis, reclined cell apoptosis, and significantly increased CD31hiEMCNhi endothelial cells (ECs) and SLIT3 and HIF‐1α expression levels in co‐cultured HUVECs and hDPSCs. Knockdown of Slit3 in hDPSCs or Hif‐1α in HUVECs impaired the formation of CD31hiEMCNhi ECs and reversed TPPU‐induced osteogenesis. We defined a previously unidentified effect of TPPU coupling angiogenesis and osteogenesis. TPPU induced type H vessels by upregulating the expression of hDPSCs‐derived SLIT3, which resulted in the activation of ROBO1/YAP1/HIF‐1α signalling pathway in ECs. Targeting metabolic pathways of EETs represents a new strategy to couple osteogenesis and angiogenesis, sEH is a promising therapeutic target for bone regeneration and repair.