bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐dependent effect of methyl eugenol on male mating success of the peach fruit fly, Bactrocera zonata
Authors: Rasool Awais , Munis Muhammad Farooq Hussain , Shah Said Hussain , Fatima Sehar , Irshad Afshan , Haq Ihsan ul 
Published: June 2023

AbstractThe peach fruit fly, Bactrocera zonata (Saunders) (Diptera: Tephritidae), is a pest of economic importance, endemic to South and South‐East Asia. It is highly invasive and due to its quarantine pest status, it interferes with horticultural trade. Males of many Bactrocera species are strongly attracted to methyl eugenol (ME) [1,2‐dimethoxy‐4‐(2‐propenyl) benzene], a phenylpropanoid compound naturally occurring in many plant species. Feeding on ME is also reported to enhance male mating success in several Bactrocera species. Such an effect can increase the effectiveness of the sterile insect technique (SIT). The current study was designed to identify the sexual maturity age of males of B. zonata, the relation between male age and attraction to ME, and the effect of ME on male mating success. The results showed that males initiated their mating at 8 days of age and attained the highest mating success at 16 days of age. The percentage of immature males responding to ME increased with age and the maximum response was observed during the age of sexual maturity. Methyl eugenol treatment at sexual maturity significantly enhanced male mating success over untreated males. The males treated with ME at a sexually immature age (5 days old) achieved significantly higher mating success after reaching sexual maturity. These findings suggested that B. zonata males can be treated with ME at the age of 5 days in sterile‐male ‘holding and release’ facilities and thereafter released in the field, where they are expected to achieve higher mating success after attaining sexual maturity. The results are discussed as a valid approach for enhancing the effectiveness of SIT application against B. zonata.
The introduced Arapaima gigas in the Bolivian Amazon: Trophic position and isotopic niche overlap with native species
Authors: Rejas Danny , Oberdorff Thierry , Declerck Steven A. J. , Winder Monika 
Published: June 2023

AbstractNon‐native fish species may generate major ecological impacts on native assemblages. This study aims to assess the potential impact of the introduced Arapaima gigas on native fish assemblages in two oxbow lakes of the Bolivian Amazon. Stable isotope data were used to determine trophic position (TP) and isotopic niche overlap, to evaluate potential predation and competition interactions, respectively. Results suggest that A. gigas is more an omnivore than a top predator, as often claimed. Arapaima gigas occupied an intermediate TP between detritivore/herbivore and piscivore fish species and showed broader isotopic niche compared to most native species analysed. The isotopic niche of A. gigas significantly overlapped with most native fish species in one lake (i.e. Lake Mentiroso), while there was low niche overlap in the second (i.e. Lake Miraflores). Given its omnivorous tendencies, the predation impact of A. gigas on other fish species is likely less than currently claimed and likely varies with the food web structure of the ecosystem. More precise data on resource availability and use are necessary to infer whether niche overlap will have negative impacts on native fish species through potential competitive interactions. Increasing our understanding on the processes generating impact of these introductions on resident communities through food web ecology will pave the way for better resource management and conservation efforts.
Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial
Authors: Williams Thomas , John Nevin , Calvi Alberto , Bianchi Alessia , De Angelis Floriana , Doshi Anisha , Wright Sarah , Shatila Madiha , Yiannakas Marios C. , Chowdhury Fatima , Stutters Jon , Ricciardi Antonio , Prados Ferran , MacManus David , Braisher Marie , Blackstone James , Ciccarelli Olga , Gandini Wheeler‐Kingshott Claudia A. M. , Barkhof Frederik , Chataway Jeremy ,   the UCL MS‐STAT2 investigators
Published: June 2023

AbstractBackground and purposeThere is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS.MethodsParticipants had SPMS, and data were collected at enrolment into the MS‐STAT2 trial. Composite CVR scores were calculated using the QRISK3 software. Prematurely achieved CVR due to modifiable risk factors was expressed as QRISK3 premature CVR, derived through reference to the normative QRISK3 dataset and expressed in years. Associations were determined with multiple linear regressions.ResultsFor the 218 participants, mean age was 54 years and median Expanded Disability Status Scale was 6.0. Each additional year of prematurely achieved CVR was associated with a 2.7 mL (beta coefficient; 95% confidence interval 0.8–4.7; p = 0.006) smaller normalized whole brain volume. The strongest relationship was seen for the cortical grey matter (beta coefficient 1.6 mL per year; 95% confidence interval 0.5–2.7; p = 0.003), and associations were also found with poorer verbal working memory performance. Body mass index demonstrated the strongest relationships with normalized brain volumes, whilst serum lipid ratios demonstrated strong relationships with verbal and visuospatial working memory performance.ConclusionsPrematurely achieved CVR is associated with lower normalized brain volumes in SPMS. Future longitudinal analyses of this clinical trial dataset will be important to determine whether CVR predicts future disease worsening.
Environmental health perceptions of urban youth from low‐income communities: A qualitative photovoice study and framework
Authors: Sprague Nadav L. , Zonnevylle Hannah M. , Jackson Hall Lexi , Williams Rosalind , Dains Hannah , Liang Donghai , Ekenga Christine C. 
Published: June 2023

AbstractBackgroundChildren are amongst the most susceptible groups to environmental exposures, for both immediate and life‐course health outcomes. Despite their increased susceptibility, children's knowledge, experiences and voices are understudied. A deeper understanding of children's environmental health perceptions has the potential to better inform policy, develop targeted interventions and improve public health outcomes.MethodsIn this study, our community–academic partnership used the Photovoice research method to examine how urban children from low‐income communities perceive environmental influences on their health. Twenty children, ages 10–12, took photographs and participated in focus group interviews regarding their perspectives on how the environment influences their health.ResultsQualitative analyses revealed five major thematic categories: environmental exposures, environmental health sentiments, environmental health outcomes, interest in environmental health and environmental health solutions. We used the findings to develop an environmental health perspective theoretical framework that can inform future work designed to promote the environmental health and well‐being of children from low‐income communities in urban communities.ConclusionPhotovoice enabled children from low‐income communities to capture and communicate their environmental health perceptions. These findings have the potential to inform and identify potential targets and opportunities for environmental health interventions and promotion in their communities.Patient or Public ContributionPartnerships with community‐based organizations were central to the present study. By design, these community‐based partners were involved in the conduct and procedures of the study.
Treatment‐emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: A case series
Authors: DeKoven Samuel , Naccarato Mark , Brumme Chanson J. , Tan Darrell H. S. 
Published: June 2023

AbstractObjectivesBictegravir/tenofovir alafenamide/emtricitabine (BIC/TAF/FTC) is a complete regimen for the treatment of HIV with a high barrier to resistance and few reported cases of treatment failure. We present three cases of treatment‐emergent resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in patients with suboptimal treatment adherence and assess whether the resistance‐associated mutations were present before BIC/TAF/FTC initiation or emerged during therapy.MethodsWe used genotypic drug resistance testing by Sanger sequencing to identify emergent resistance mutations in plasma viral load specimens collected after combination antiretroviral therapy initiation in all participants. Additionally, we performed ultra‐deep sequencing by Illumina MiSeq on the earliest available plasma HIV‐1 viral load specimen and on any available specimens closest in time to the initiation of BIC/TAF/FTC therapy to identify low‐abundance resistance mutations present in the viral quasispecies.ResultsAll three participants developed NRTI resistance after prolonged exposure and incomplete adherence to BIC/TAF/FTC. The T69N, K70E, M184I, and/or T215I mutations identified in clinical samples at the time of virological failure were not present on deep sequencing of either baseline samples or samples collected before BIC/TAF/FTC initiation.ConclusionsDespite a generally high genetic barrier to resistance, NRTI resistance‐associated mutations may emerge during therapy with BIC/TAF/FTC in the setting of suboptimal adherence.
Juniper berry extract containing Anthricin and Yatein suppresses lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases spots in human skin
Authors: Sakamoto Kotaro , Fujimoto Runa , Nakagawa Satoshi , Kamiyama Erina , Kanai Kyoko , Kawai Yuka , Kojima Hiroyuki , Hirasawa Asuka , Wakamatsu Kanae , Masutani Teruaki 
Published: June 2023

AbstractObjectiveSkin brightness and spot have a significant impact on youthful and beautiful appearance. One important factor influencing skin brightness is the amount of internal reflected light from the skin. Observers recognize the total surface‐reflected light and internal reflected light as skin brightness. The more internal reflected light from the skin, the more attractive and brighter the skin appears. This study aims to identify a new natural cosmetic ingredient that increases the skin's internal reflected light, decreases spot and provides a youthful and beautiful skin appearance.MethodsLipofuscin in epidermal keratinocytes, the aggregating complex of denatured proteins and peroxidized lipids, is one factor that decreases skin brightness and causes of spot. Aggregates block light transmission, and peroxidized lipids lead to skin yellowness, dullness and age spot. Lipofuscin is known to accumulate intracellularly with ageing. Rapid removal of intracellular denatured proteins prevents lipofuscin formation and accumulation in cells. We focused a proteasome system that efficiently removes intracellular denatured proteins. To identify natural ingredients that increase proteasome activity, we screened 380 extracts derived from natural products. The extract with the desired activity was fractionated and purified to identify active compounds that lead to proteasome activation. Finally, the efficacy of the proteasome‐activating extract was evaluated in a human clinical study.ResultsWe discovered that Juniperus communis fruits (Juniper berry) extract (JBE) increases proteasome activity and suppresses lipofuscin accumulation in human epidermal keratinocytes. We found Anthricin and Yatein, which belong to the lignan family, to be major active compounds responsible for the proteasome‐activating effect of JBE. In a human clinical study, an emulsion containing 1% JBE was applied to half of the face twice daily for 4 weeks, resulting in increased internal reflected light, brightness improvement (L‐value) and reduction in yellowness (b‐value) and spot in the cheek area.ConclusionThis is the first report demonstrating that JBE containing Anthricin and Yatein decreases lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases surface spots in human skin. JBE would be an ideal natural cosmetic ingredient for creating a more youthful and beautiful skin appearance with greater brightness and less spot.
Four decades of negative word‐of‐mouth and negative electronic word‐of‐mouth: A morphological analysis
Authors: Ribeiro Dahlia Allwyn , Kalro Arti D. 
Published: June 2023

AbstractCustomers voice their negative brand experiences to their family and friends in the form of negative word‐of‐mouth (NWOM). Web 2.0 enables the sharing of NWOM in electronic format on various social media sites, online customer review forums, and blogs, which is known as negative electronic word‐of‐mouth (NeWOM). Researchers need to study the spread of NWOM/NeWOM to prevent adverse consequences for companies and suggest an optimal response for its redressal. Existing literature review studies have focused on word‐of‐mouth (WOM) and electronic WOM (eWOM) and have considered both positive and negative WOM and eWOM concurrently. Past literature reviews have captured the breadth of the WOM domain, ignoring the depth. This research article contains a review of 282 journal papers capturing the depth of the extant literature by focusing solely on ‘negative’ WOM and eWOM (NWOM and NeWOM), and presents a broad view of the NWOM and NeWOM domains using morphological analysis (MA). This will help to conceptualize and categorize the existing state‐of‐the‐art literature into broad dimensions and identify future research opportunities. The MA framework helps to bifurcate this literature into the following four dimensions: (i) nomenclature of NWOM and NeWOM, (ii) antecedents of NWOM/NeWOM, (iii) impacts of NWOM/NeWOM, and (iv) prevention and recovery response to NeWOM. Further dissection of these four dimensions leads to 15 sub‐dimensions and 217 variants. Combinations of the 217 variants enable the identification of 550 novel future research opportunities in the area of NWOM and NeWOM.
Adoption of Internet of Things: A systematic literature review and future research agenda
Authors: Kumar Anil , Dhingra Sanjay , Falwadiya Himanshu 
Published: June 2023

AbstractThe Internet of Things (IoT) is one of the promising technologies in industry 4.0, which has the potential to provide a myriad of advantages and offer convenience to individuals' daily lives and efficiency to businesses. Due to the enormous potential of the Internet of things, attention towards its adoption is increasing significantly. Despite the undeniable relevance of this field, the current study aims to synthesize the body of knowledge on IoT adoption using systematic literature review (SPAR‐4‐SLR) with the TCCM framework. A total of 101 articles were carefully selected after a thorough search in the Web of Science and Scopus databases. This study has performed an in‐depth descriptive analysis to present the current state of knowledge. The findings of this study revealed that the Technology acceptance model and Unified theory of acceptance and use of technology were the most widely employed theories and models in previous literature. Furthermore, this study has developed an integrative conceptual framework including antecedents, mediators, moderators, and outcomes. Also, the antecedents are classified into four categories based on the Technology‐organization‐environment framework with end user‐specific category. By integrating the existing knowledge, the study identifies significant gaps and offers a fertile ground for further investigation in this field.
Modeling microvoiding kinetics of rare‐earth disilicates in flowing atmospheres containing water vapor
Authors: Wan Julin , Meschter Peter J. , Bertram Brian 
Published: June 2023

AbstractRare‐earth disilicate (REDS, RE2Si2O7) layers that may be used as environmental barrier coatings (EBCs) on ceramic matrix composite (CMC) components in high‐temperature stages of turbine engines are subject to microvoiding to form porous rare‐earth monosilicate (REMS, RE2SiO5) layers in flowing atmospheres containing water vapor. A simple microvoiding kinetic model that incorporates both mass transfer of the reaction product Si(OH)4(g) through the external gas phase boundary layer and pore diffusion of Si(OH)4(g) through the microvoided layer has been developed. Model predictions are in good agreement with measured growth rates of microvoided layers under low‐flowrate steam furnace test and high‐flowrate burner rig conditions. Since pore diffusion is generally the rate‐limiting step for EBC microvoiding in turbine engines, furnace testing under conditions of kinetic control by gas phase mass transfer is not generally capable of predicting REDS microvoiding rates under engine conditions. The kinetic model can be extended to incorporate changes in pore size and distribution, cracking of the microvoided layer, and introduction and cracking of an additional REMS topcoat to the system. The model can be used to generate a reasonable prediction of the time required to fully microvoid a REDS EBC layer on a CMC component in the hot gas path of an aircraft engine or stationary gas turbine.
A facile route for the synthesis of high‐entropy transition carbides/borides at low temperatures
Authors: Li Yao , Wang Yu , Zhang Guo‐Hua 
Published: June 2023

AbstractAs the main candidates in the field of ultra‐high temperature ceramics, high entropy carbides/borides (HECs/HEBs) have good oxidation resistance properties, high hardness, as well as excellent thermal and electrical conductivities, which are the focused points of research nowadays. In the current study, (Hf,Ta,Zr,Nb,Mo,Ti)C powders were successfully synthesized by a three‐step process, including the mixing process of raw oxides and carbon black with spaying Fe(NO3)3 solution, carbothermal reduction and subsequent calcium posttreatment. For the preparation of (Hf,Ta,Zr,Nb,Mo,Ti)B2 powders, during the calcium posttreatment process, equal stoichiometric ratio of B4C was added for the purpose of boriding reaction. The relevant X‐ray diffraction and SEM characterizations indicate the successful preparations of face‐centered cubic HECs and hexagonal HEBs. However, slight Mo local segregation was found in the prepared (Hf,Ta,Zr,Nb,Mo,Ti)B2 powders. The iron generated from Fe(NO3)3 promotes the solid solution process between monocarbides during the carbothermal reduction process via the dissolution‐diffusion‐precipitation mechanism. In the calcium posttreatment process, the liquid calcium ensures the boriding reaction take place at a low temperature. In addition, the residual carbon could be combined with calcium to generate CaC2 which is easy to be removed by acid leaching, and meanwhile, the added Fe could also be finally eliminated to produce pure HEC/HEB powders. The current method does not require the long‐time high energy ball milling of raw materials, but only simple and mild mixing is enough. Therefore, such a facile route has a great potential application prospect for industrially preparing high entropy phase powders in a large scale.
Can group‐based strategies increase community resilience? Longitudinal predictors of sustained participation in Covid‐19 mutual aid and community support groups
Authors: Perach Rotem , Fernandes‐Jesus Maria , Miranda Daniel , Mao Guanlan , Ntontis Evangelos , Cocking Chris , McTague Michael , Semlyen Joanna , Drury John 
Published: June 2023

AbstractMutual aid groups have been a critical part of the coronavirus disease‐2019 (Covid‐19) response and continue to address the needs of people in their communities. To understand how mutual aid and similar community support groups can be sustained over time, we test the idea that using group‐based strategies initiates psychological trajectories that shape future participation. We conducted a preregistered longitudinal survey among Covid‐19 mutual aid and community support volunteers in the United Kingdom (nWave 1 = 600, May 2021; nWave 2 = 299, July–August 2021) who were registered panelists of an independent research organization. Assessments included measures of group‐based strategies, collective participation predictors, participation experience, and sustained participation. Volunteers engaged in a wide range of support activities including shopping, emotional support provision, and deliveries. Two group‐based strategies—group alliances and group horizontality—longitudinally predicted sustained participation. In addition, sense of community responsibility and burnout were longitudinal predictors of sustained participation. Importantly, predictors of sustained participation diverged for volunteers with different levels of volunteering experience. Our findings highlight group‐based strategies as a potential resource for organizers seeking to sustain participation. Use can be tailored depending on the profiles of individual Covid‐19 mutual aid volunteers. These findings have significance beyond Covid‐19 as they are relevant to sustaining community resilience more generally.
Abrocitinib effect on patient‐reported outcomes in patients with moderate‐to‐severe atopic dermatitis: Results from phase 3 studies, including the long‐term extension JADE EXTEND study
Authors: Reich K. , Silverberg J. I. , Papp K. A. , Deleuran M. , Katoh N. , Strober B. , Beck L. A. , de Bruin‐Weller M. , Werfel T. , Zhang F. , Biswas P. , DiBonaventura M. D. , Chan G. , Farooqui S. A. , Kerkmann U. , Clibborn C. 
Published: June 2023

AbstractBackgroundAbrocitinib improved signs and symptoms of moderate‐to‐severe atopic dermatitis (AD) at Weeks 12 and 16 in phase 3 studies, with a manageable safety profile. Patient‐reported outcomes with long‐term abrocitinib treatment were not reported.ObjectiveTo evaluate patient‐reported outcomes with long‐term abrocitinib treatment in patients with moderate‐to‐severe AD.MethodsJADE EXTEND (NCT03422822) is an ongoing, phase 3, long‐term extension study that enrolled patients from previous abrocitinib AD trials. This analysis includes patients from the phase 3 trials JADE MONO‐1 (NCT03349060), JADE MONO‐2 (NCT03575871) and JADE COMPARE (NCT03720470) who completed the full treatment period of placebo or abrocitinib (200 or 100 mg once daily) and subsequently entered JADE EXTEND and were randomised to receive once‐daily abrocitinib 200 or 100 mg. Patient‐reported endpoints to Week 48 included the proportion of patients who achieved Dermatology Life Quality Index (DLQI) scores of 0/1 (no effect of AD on quality of life [QoL]) and a ≥4‐point improvement in Patient‐Oriented Eczema Measure (POEM) score (clinically meaningful improvement). Data cut‐off: April 22, 2020.ResultsBaseline DLQI mean scores were 15.4 and 15.3 in the abrocitinib 200‐ and 100‐mg groups, respectively, which corresponded to a ‘very large effect’ on QoL; at Week 48, mean DLQI scores were lower with abrocitinib 200 mg (4.6; ‘small effect’ on QoL) and abrocitinib 100 mg (5.9; ‘moderate effect’ on QoL). Baseline POEM mean scores were 20.4 and 20.5 in the abrocitinib 200‐ and 100‐mg groups, respectively; at Week 48, mean POEM scores were 8.2 and 11.0. Week 48 patient‐reported responses with abrocitinib 200 mg and abrocitinib 100 mg were 44% and 34% for DLQI 0/1, and 90% and 77% for a ≥4‐point reduction in POEM score.ConclusionIn patients with moderate‐to‐severe AD, long‐term abrocitinib treatment resulted in clinically meaningful improvement in patient‐reported symptoms of AD, including QoL.