bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delta-radiomics models based on multi-phase contrast-enhanced magnetic resonance imaging can preoperatively predict glypican-3-positive hepatocellular carcinoma
Authors: Han Zewen , Dai Hanting , Chen Xiaolin , Gao Lanmei , Chen Xiaojie , Yan Chuan , Ye Rongping , Li Yueming 
Published: August 2023

Objectives: The aim of this study is to investigate the value of multi-phase contrast-enhanced magnetic resonance imaging (CE-MRI) based on the delta radiomics model for identifying glypican-3 (GPC3)-positive hepatocellular carcinoma (HCC).Methods: One hundred and twenty-six patients with pathologically confirmed HCC (training cohort: n = 88 and validation cohort: n = 38) were retrospectively recruited. Basic information was obtained from medical records. Preoperative multi-phase CE-MRI images were reviewed, and the 3D volumes of interest (VOIs) of the whole tumor were delineated on non-contrast T1-weighted imaging (T1), arterial phase (AP), portal venous phase (PVP), delayed phase (DP), and hepatobiliary phase (HBP). One hundred and seven original radiomics features were extracted from each phase, and delta-radiomics features were calculated. After a two-step feature selection strategy, radiomics models were built using two classification algorithms. A nomogram was constructed by combining the best radiomics model and clinical risk factors.Results: Serum alpha-fetoprotein (AFP) (p = 0.013) was significantly related to GPC3-positive HCC. The optimal radiomics model is composed of eight delta-radiomics features with the AUC of 0.805 and 0.857 in the training and validation cohorts, respectively. The nomogram integrated the radiomics score, and AFP performed excellently (training cohort: AUC = 0.844 and validation cohort: AUC = 0.862). The calibration curve showed good agreement between the nomogram-predicted probabilities and GPC3 actual expression in both training and validation cohorts. Decision curve analysis further demonstrates the clinical practicality of the nomogram.Conclusion: Multi-phase CE-MRI based on the delta-radiomics model can non-invasively predict GPC3-positive HCC and can be a useful method for individualized diagnosis and treatment.
Cognitive control in adults with high-functioning autism spectrum disorder: a study with event-related potentials
Authors: Möde Laura , Borgolte Anna , Ghaneirad Erfan , Roy Mandy , Sinke Christopher , Szycik Gregor R. , Bleich Stefan , Wiswede Daniel 
Published: August 2023

IntroductionLittle is known about cognitive control in adults with high-functioning forms of autism spectrum disorder because previous research focused on children and adolescents. Cognitive control is crucial to monitor and readjust behavior after errors to select contextually appropriate reactions. The congruency effect and conflict adaptation are measures of cognitive control. Post-error slowing, error-related negativity and error positivity provide insight into behavioral and electrophysiological correlates of error processing. In children and adolescent with autism spectrum disorder deficits in cognitive control and error processing have been shown by changes in post-error slowing, error-related negativity and error positivity in the flanker task.MethodsWe performed a modified Eriksen flanker task in 17 adults with high-functioning autism spectrum disorder and 17 healthy controls. As behavioral measures of cognitive control and error processing, we included reaction times and error rates to calculate congruency effects, conflict adaptation, and post-error slowing. Event-related potentials namely error-related negativity and error positivity were measured to assess error-related brain activity.ResultsBoth groups of participants showed the expected congruency effects demonstrated by faster and more accurate responses in congruent compared to incongruent trials. Healthy controls exhibited conflict adaptation as they obtained performance benefits after incongruent trials whereas patients with autism spectrum disorder did not. The expected slowing in reaction times after errors was observed in both groups of participants. Individuals with autism spectrum disorder demonstrated enhanced electrophysiological error-processing compared to healthy controls indicated by increased error-related negativity and error positivity difference amplitudes.DiscussionOur findings show that adults with high-functioning autism spectrum disorder do not show the expected upregulation of cognitive control in response to conflicts. This finding implies that previous experiences may have a reduced influence on current behavior in these patients which possibly contributes to less flexible behavior. Nevertheless, we observed intact behavioral reactions after errors indicating that adults with high-functioning autism spectrum disorder can flexibly adjust behavior in response to changed environmental demands when necessary. The enhancement of electrophysiological error-processing indicates that adults with high-functioning autism spectrum disorder demonstrate an extraordinary reactivity toward errors reflecting increased performance monitoring in this subpopulation of autism spectrum disorder patients.
Development and Characterization of Antioxidant and Antibacterial Films Based on Potato Starch Incorporating Viola odorata Extract to Improve the Oxidative and Microbiological Quality of Chicken Fillets during Refrigerated Storage
Authors: Nikmanesh Ali , Baghaei Homa , Mohammadi Nafchi Abdorreza 
Published: August 2023

In this research, the antioxidant and antibacterial activities of active films based on potato starch containing Viola odorata extract (VOE) were investigated both in vitro and in chicken fillets. The VOE was added to the starch film formulation at 0, 1, 2, and 3% (w/v). The results showed that by increasing the extract level, the total phenol content and antioxidant and antibacterial activity of the films against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium improved remarkably. The results of the meat tests indicated the significant antioxidant and antimicrobial activity of active films containing different levels of VOE in chicken fillets, and a direct relationship was observed between the concentration of the extract and the functional activity of the films, so with the increase in the concentration of the extract in the films, the rate of lipid oxidation and growth of microorganisms in the chicken fillets decreased significantly during the storage period, and less volatile nitrogen bases, metmyoglobin, and oxidation products were produced in the fillets. In general, the results of this research demonstrated that an active film based on potato starch containing VOE (especially 2 and 3% levels) has the ability to extend the oxidative and microbiological shelf life of chicken fillets during cold storage for at least eight days.
Functional Divergence of the Tribolium castaneum engrailed and invected Paralogs
Authors: Blunk Summer , Garcia-Verdugo Hector , O’Sullivan Sierra , Camp James , Haines Michael , Coalter Tara , Williams Terri A. , Nagy Lisa M. 
Published: August 2023

Engrailed (en) and invected (inv) encode paralogous transcription factors found as a closely linked tandem duplication within holometabolous insects. Drosophila en mutants segment normally, then fail to maintain their segments. Loss of Drosophila inv is viable, while loss of both genes results in asegmental larvae. Surprisingly, the knockdown of Oncopeltus inv can result in the loss or fusion of the entire abdomen and en knockdowns in Tribolium show variable degrees of segmental loss. The consequence of losing or knocking down both paralogs on embryogenesis has not been studied beyond Drosophila. To further investigate the relative functions of each paralog and the mechanism behind the segmental loss, Tribolium double and single knockdowns of en and inv were analyzed. The most common cuticular phenotype of the double knockdowns was small, limbless, and open dorsally, with all but a single, segmentally iterated row of bristles. Less severe knockdowns had fused segments and reduced appendages. The Tribolium paralogs appear to act synergistically: the knockdown of either Tribolium gene alone was typically less severe, with all limbs present, whereas the most extreme single knockdowns mimic the most severe double knockdown phenotype. Morphological abnormalities unique to either single gene knockdown were not found. inv expression was not affected in the Tribolium en knockdowns, but hh expression was unexpectedly increased midway through development. Thus, while the segmental expression of en/inv is broadly conserved within insects, the functions of en and inv are evolving independently in different lineages.
Meningkatkan Kemampuan Mengenal Lambang Bilangan Melalui Media Pembelajaran Audio Visual pada Anak Usia 4-5 Tahun di TK Negeri Herlina Tikatukang Kecamatan Adonara Kabupaten Flores Timur
Authors: Azriyani Mutalib  , Ma’rup  , Latief Fadhilah 
Published: August 2023

This study aims to improve the ability to recognize number symbols through audio-visual learning media in children aged 4-5 years at Herlina Tikatukang State Kindergarten, Adonara District, East Flores Regency. This type of research is classroom action research. The subjects in this study were 11 children. Methods of data collection in the form of observation and documentation. The instrument used is an observation sheet in the form of a checklist. Data analysis techniques use qualitative descriptive and quantitative descriptive. The results of observations before the action showed that children who had the ability to recognize number symbols in cycle I was 52.27%, increasing to 89.33% in cycle II and having achieved a success indicator of 80%. Based on these results it can be concluded that audio-visual learning media can improve the ability to recognize number symbols at the age of 4-5 years at TK Herlina Tikatukang Adonara District, East Flores Regency.
ABSTRAK
Penelitian ini bertujuan untuk meningkatkan kemampuan mengenal lambang bilangan melalui media pembelajaran audio visual pada anak usia 4-5 tahun di TK Negeri Herlina Tikatukang Kecamatan Adonara Kabupaten Flores Timur. Jenis penelitian ini merupakan penelitian tindakan kelas. Subjek dalam penelitian ini sebanyak 11 anak. Metode pengumpulan data berupa observasi dan dokumentasi. Instrumen yang digunakan berupa lembar observasi yang berbentuk checklist. Teknik Analisis data menggunakan Deskriptif Kualitatif dan Deskriptif Kuantitatif. Hasil observasi sebelum tindakan menunjukkan bahwa anak yang memiliki kemampuan mengenal lambang bilangan pada siklus I adalah 52,27% meningkat menjadi 91,66% pada siklus II dan telah mencapai indikator keberhasilan yaitu 80%. Berdasarkan hasil tersebut dapat disimpulkan bahwa media pembelajaran audio visual dapat meningkatkan kemampuan mengenal lambang bilangan pada usia 4-5 tahun di TK Negeri Herlina Tikatukang Kecamatan Adonara Kabupaten Flores Timur.
Peran Manajemen Sarana dan Prasarana dalam Menstimulasi Kreativitas Anak Usia Dini
Authors: Asriyani Solatiyah , Munastiwi Erni 
Published: August 2023

Educational facilities and infrastructure are one indicator of the quality of an educational institution. However, in reality, many facilities and infrastructure are not properly managed and optimized. Therefore, it is necessary to understand and implement facilities and infrastructure management to help broaden insight into the role of facility and infrastructure management in optimizing the teaching and learning process and stimulating and optimizing aspects of development in students. This study aims to determine the role of management of PAUD facilities and infrastructure in stimulating children's creativity, which is an aspect that must be further developed in children. This study uses the SLR (Systematic Literature Review) method. This research collects data by documenting and reviewing articles that are relevant to this research. Then the researcher reviewed the 10 articles obtained from Google Scholar. The results of the discussion from this study are based on a literature review conducted where management of facilities and infrastructure is needed in learning activities, especially in stimulating early childhood creativity.

ABSTRAK
Sarana dan prasarana pendidikan merupakan salah satu indikator mutu suatu lembaga pendidikan. Namun kenyataannya banyak sarana dan prasarana yang tidak dikelola dan dioptimalkan sebagaimana mestinya. Oleh sebab itu, perlunya pemahaman dan pengimplementasian mengenai manajemen sarana dan prasarana untuk membantu memperluas wawasan mengenai peran manajemen sarana dan prasarana dalam mengoptimalkan proses belajar mengajar dan menstimulasi serta mengoptimalkan aspek-aspek perkembangan pada peserta didik. Penelitian ini bertujuan untuk mengetahui peran manajemen sarana dan prasarana PAUD dalam menstimulasi kreativitas anak yang merupakan aspek yang harus dikembangkan lebih lanjut pada anak. Penelitian ini menggunakan metode SLR (Systematic Literature Review). Penelitian ini mengumpulkan data dengan cara mendokumentasi dan mengulas kembali artikel yang relevan dengan penelitian ini. Kemudian peneliti mereview 10 artikel yang didapatkan dari Google Scholar. Adapun hasil pembahasan dari penelitian ini adalah berdasarkan kajian literatur yang dilakukan bahwa manajemen sarana dan prasarana sangat diperlukan dalam kegiatan pembelajaran terutama dalam menstimulus kreativitas anak usia dini
Perbedaan Kemandirian Antara Anak Sulung dengan Anak Tunggal di RA As-Sa’adah Medan
Authors: Arrumaisha  
Published: August 2023

The purpose of this study was to compare and contrast the level of early childhood independence between the firstborn and the only child. This research uses a quantitative approach with a comparative method. The sampling technique used was purposive sampling with the criteria (1) children aged between 5 and 6 years; (2) The oldest sibling in a family with younger siblings and the only child in a family without siblings is the target population. A sample of 50 children was used in this study, 25 of whom were the oldest (firstborn) and 25 of whom were the only children in their family (only child). The Early Childhood Independence Scale was used to collect data for this study. As for analyzing the data, we used an independent sample t-test for the statistical significance of the difference. The results showed that the oldest child (the firstborn) had an average score of 73.95, while the only child had a score of 64.61, based on statistical calculations. Based on the results of the Independent Sample t-test, it is known that there is a statistically significant difference between the level of independence of the eldest child and the only child in RA As-Sa' Medan because t count > t table (5.144 > 1.677) and sig value (0.000 < 0.05).

ABSTRAK
Tujuan penelitian ini untuk membandingkan dan membedakan tingkat kemandirian anak usia dini antara anak sulung dan anak tunggal. Penelitian ini menggunakan pendekatan kuantitatif dengan metode komparatif. Teknik sampling yang digunakan adalah Purposive Sampling dengan kriteria (1) Anak-anak berusia antara 5 dan 6 tahun; (2) Saudara tertua dalam keluarga yang punya adik, dan anak tunggal dalam keluarga tanpa saudara kandung sama sekali merupakan populasi sasaran. Sampel penelitian sebanyak 50 anak digunakan dalam penelitian ini, 25 di antaranya adalah yang tertua (anak sulung) dan 25 di antaranya adalah satu-satunya anak di keluarga mereka (anak tunggal). Skala Kemandirian Anak Usia Dini digunakan untuk mengumpulkan data penelitian ini. Adapun untuk menganalisis data digunakan Uji-t (Independent Sample t-Test) untuk signifikansi statistik perbedaan. Hasil penelitian menunjukkan anak tertua (anak sulung) memiliki skor rata-rata 73,95, sedangkan anak tunggal memiliki skor 64,61, berdasarkan perhitungan statistik. Berdasarkan hasil Independent Sample t-Test diketahui bahwa terdapat perbedaan yang signifikan secara statistik antara tingkat kemandirian anak sulung dengan anak tunggal di RA As-Sa' Medan karena t hitung > t tabel (5,144 > 1,677) dan nilai sig (0,000 < 0,05).
Implementasi Sarana Prasarana Esensial Terhadap Kurikulum Merdeka Anak Usia Dini
Authors: Utami-kumala-dewi  , Hibana  , Nurhusni Kamil  , Fadila Arnisa Harahap  , Faiqatuz Zahrah  
Published: August 2023

The era of entering the industrial revolution 5.0, education is closely related to world attention regarding an institution, especially early childhood education. The success of the learning process of an institution is supported by the availability of adequate essential infrastructure facilities according to the applicable curriculum. The independent curriculum is a curriculum that applies in Indonesia with a fun learning orientation centered on students, as well as the creativity of educators in providing a variety of learning to be the main factor in achieving the learning process. Freedom of learning does not prioritize Calistung learning (Read, Write, Count), and is centered on LKA (Children's Worksheets). Therefore, the researcher is interested in examining more deeply the implementation of infrastructure for the independence curriculum at Pangudi Luhur Jenarwetan Kindergarten. Researchers used qualitative research methods that are descriptive analytic by collecting data through observation, documentation and interview techniques. The results of this study are the implementation of infrastructure that has been used during the learning process using an independent curriculum, one of which uses natural materials.

ABSTRAK
Era memasuki revolusi industri 5.0 pendidikan erat kaitannya dari perhatian dunia mengenai suatu lembaga khususnya pendidikan anak usia dini. Keberhasilan proses pembelajaran suatu lembaga didukung dengan tersedianya sarana prasarana esesnsial yang memadai sesuai kurikulum yang berlaku. Kurikulum merdeka merupakan kurikulum yang berlaku di Indonesia dengan berorientasi pembelajaran yang menyenangkan berpusat pada peserta didik, serta kreativitas pendidik dalam menyediakan ragam pembelajaran menjadi faktor utama tercapainya proses pembelajaran. Merdeka belajar tidak mengutamakan pada pembelajaran Calistung (Baca, Tulis, Hitung), dan berpusat pada LKA (Lembar Kerja Anak). Maka dari itu, peneliti tertarik untuk mengkaji lebih dalam tentang implementasi sarana prasarana terhadap kurikulum merdeka di TK Pangudi Luhur Jenarwetan. Peneliti menggunakan metode penelitian kualitatif bersifat deskriptif analitik dengan pengumpulan data melalui teknik observasi, dokumentasi dan wawancara. Hasil dari penelitian ini berupa implementasi sarana prasarana yang telah digunakan selama proses pembelajaran menggunakan kurikulum merdeka, salah satunya menggunakan bahan alam.
PENGEMBANGAN SUMBER BELAJAR BIOLOGI BERBASIS KARTU BERGAMBAR DILENGKAPI MEDIA GAME OBINO (Onet Binomial Nomenclature) PADA MATERI DUNIA TUMBUHAN
Authors: Rahmayani Rahmayani 
Published: August 2023

This research is motivated by the existence of problems in the field based on the results of interviews with biology teachers class X MIPA 5 Senior High School that the learning resources used in the biology learning process, especially about the material of plant world, are still conventional and their availability is still very lacking, make students bored. In addition, based on the analysis of the needs students as much as 100 requires learning resources that are more innovative and based technology. The purpose of this research is to develop biological learning resources based on picture cards completely by media game OBINO on valid and practical on plant world. This research is a type of research and development using the ADDIE model and produces learning resources for Flora Angiospermae. The results of expert validator on the learning resources of Flora Angiospermae are very valid based on the percentage of validator assessment, which is 91.80% and are very practical based on the percentage of practitioner assessment (teacher response), namely 92.00% and the percentage of practitioner assessment (student response) 91.08%, so it is feasible used in the learning process.[R1] Keywords: Game OBINO, Learning Resources, Plant world, Picture Cards.
Rural Entrepreneurship through Vermicomposting – Case Studies
Authors: Tyagi K.S. , Singh D.P. , Gupta Rajive K 
Published: August 2023

Solid waste management continue to be a major challenge and permanent problem of urban as well as semi-urban areas of the country. A number of initiatives have been taken by several public and private sector organizations to overcome this serious problem. One such initiative taken at the Dev Sanskriti Vishwavidyalaya (DSVV), Haridwar has successfully turned the bio-degradable part of the solid waste into a thriving and profitable enterprise. DSVV has transferred this technology to a number of entrepreneurs through their on-going capacity development programmes for rural development and organic farming. The paper describes how DSVV continue to manage its solid waste of over 5 MT generated daily in the Campus as well as that of Shantikunj by converting it into valuable vermicompost and handmade paper, after segregation, and thus helping DSVV as well as Shantikunj to become completely organic in managing their total area of over 200 acres lush green campus. The paper also describes how rural entrepreneurship training on vermicomposting at DSVV has helped three entrepreneurs, besides many, to develop large commercial vermicompost units with attractive returns. The paper also highlight potential of vermicomposting in solid waste management, employment generation and organic farming with least damage to environment.
Daya Terima Modifikasi Ikan Sarden dan Sayur Bayam pada Dimsum Sebagai Makanan Tambahan Tinggi Kalsium
Authors: Rotua Manuntun , Putri Sesiel K , Podojoyo Podojoyo , Sriwiyanti Sriwiyanti 
Published: August 2023

Osteoporosis is a bone disease characterized by a decrease in bone density which causes bones to become brittle, bone conditions deteriorate where bone pores are porous. According to data from the Indonesian Ministry of Health, the prevalence of osteoporosis in 2016 there were 3,385 people who came to puskesmas with cases of Osteoporosis, consisting of 1,115 in men and 2,270 cases in women. From data from the Palembang City Health Office in 2017, there were 112 people who came to the South Sumatra Health Center with cases of osteoporosis, consisting of 37 men and 75 women. Strategies to overcome the problem by consuming foods that are high in calcium, such as milk, sardines, salmon, fish eaten with their bones (anchovies), soy-based foods, fruits, and green vegetables. The study was conducted using a non-factorial complete randomized design (RAL), using 30 untrained panelists. Acceptability is carried out by organoleptic tests. The results of the organoleptic test of dimsum selected in the F1 formulation (150 grams of sardines and 25 grams of spinach), the results of the acceptability test obtained an average color value of 3,567, aroma of 3.07, taste of 3.87, and texture of 3.47. The results of proximate analysis obtained an energy content of 203.74 kcal, protein 8.75%, fat, 1.82%, carbohydrates 38.09%, and calcium 96.42 mg.
JUSTINO CARLO, EL CARLETTO: CRIMEN Y PSIQUIATRÍA EN RÍO DE JANEIRO DE PRIMERA REPÚBLICA
Authors: DIAS Allister Andrew Teixeira 
Published: August 2023

Este artículo analiza la historia de Carletto, considerado uno de los más famosos criminales de Brasil de la Primera República. Sospecho de alienación mental antes de ser juzgado, pasó por minucioso examen psiquiátrico. Tomamos la historia de Carletto como puerta de entrada para comprender los saberes articulados en la práctica psiquiátrica-forense vigente en la ciudad de Río de Janeiro del período. Concluimos que la construcción de la figura de Carletto como criminal peligroso y no un enfermo mental irresponsable se relaciona, por un lado, en el entrecruzamiento de los discursos psiquiátricos con las imágenes de Carletto en el imaginario popular, y, por otro, con los límites y ambigüedades del degeneracionismo.