bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Frq–Frh Complex Light-Dependently Delays Sfl1-Induced Microsclerotia Formation in Verticillium dahliae
Authors: Nagel Alexandra , Leonard Miriam , Maurus Isabel , Starke Jessica , Schmitt Kerstin , Valerius Oliver , Harting Rebekka , Braus Gerhard H. 
Published: July 2023

The vascular plant pathogenic fungus Verticillium dahliae has to adapt to environmental changes outside and inside its host. V. dahliae harbors homologs of Neurospora crassa clock genes. The molecular functions and interactions of Frequency (Frq) and Frq-interacting RNA helicase (Frh) in controlling conidia or microsclerotia development were investigated in V. dahliae JR2. Fungal mutant strains carrying clock gene deletions, an FRH point mutation, or GFP gene fusions were analyzed on transcript, protein, and phenotypic levels as well as in pathogenicity assays on tomato plants. Our results support that the Frq–Frh complex is formed and that it promotes conidiation, but also that it suppresses and therefore delays V. dahliae microsclerotia formation in response to light. We investigated a possible link between the negative element Frq and positive regulator Suppressor of flocculation 1 (Sfl1) in microsclerotia formation to elucidate the regulatory molecular mechanism. Both Frq and Sfl1 are mainly present during the onset of microsclerotia formation with decreasing protein levels during further development. Induction of microsclerotia formation requires Sfl1 and can be delayed at early time points in the light through the Frq–Frh complex. Gaining further molecular knowledge on V. dahliae development will improve control of fungal growth and Verticillium wilt disease.
Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
Authors: Iordache Miorita Melina , Belu Anca Mihaela , Vlad Sabina E. , Aivaz Kamer Ainur , Dumitru Andrei , Tocia Cristina , Dumitru Eugen 
Published: July 2023

Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety, and quality of life. Materials and Methods: This cross-sectional study included 30 confirmed patients with Crohn’s disease (CD) and ulcerative colitis (UC) who were assessed using clinical interviews for determining the severities of mental disorders (i.e., depression severity—PHQ-9, anxiety—GAD-7) and the quality of life (EQ-5D). Stool samples were collected from all participants for measuring their levels of calprotectin. Results: The level of calprotectin is correlated with PHQ-9 (ρ = 0.416, p = 0.022) and EQ-5D (ρ = −0.304, p = 0.033) but not with GAD 7 (ρ = 0.059, p = 0.379). Calprotectin levels in patients with mild, moderate, and moderately severe depression were significantly higher than in patients with minimal depression (198 µg/g vs. 66,9 µg/g, p = 0.04). Calprotectin level was corelated with the following depressive symptoms: autolytic ideation (ρ = 0.557, p = 0.001), fatigue (ρ = 0.514, p = 0.002), slow movement (ρ = 0.490, p = 0.003), and sleep disorders (ρ = 0.403, p = 0.014). Calprotectin was an independent predictor of depression with an odds ratio of 1.01 (95%: 1.002–1.03, p < 0.01). An ROC analysis showed that a level of calprotectin of 131 µg/g or higher has a sensitivity of 82%, a specificity of 61%, and an accuracy of 70% for predicting depression. In this study, no significant correlations were found between calprotectin level and anxiety. Conclusions: Calprotectin levels are associated with the severity of depression, and checking for a calprotectin level of 131 µg/g or higher may be a potential accessible screening test for depression in patients with inflammatory bowel disease.
Potent In Vitro and In Vivo Effects of Stachys lavandulifolia Methanolic Extract against Toxoplasma gondii Infection
Authors: Alanazi Abdullah D. , Majeed Qais A. H. , Alnomasy Sultan F. , Almohammed Hamdan I. 
Published: July 2023

The present study aimed to evaluate the in vitro, in vivo, and safety of Stachys lavandulifolia Vahl. methanolic extract (SLME) against acute toxoplasmosis caused by Toxoplasma gondii RH strain in mice. Methods: MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to evaluate the in vitro effect of the SLME on T. gondii tachyzoites. Totally, 72 male BALB/c mice (40 mice for in vivo evaluation of SLME and 32 mice for its toxicity effects on liver and kidney serum enzymes) were used for the present investigation. At first, 40 mice were orally pre-treated with the SLME at doses of 25, 50, and 75 mg/kg/day for two weeks. Mice were checked daily, and the rate of survival and the mean number of tachyzoites were recorded. Liver lipid peroxidation (LPO) and nitric oxide (NO) levels, the effects on kidney and liver function, as well as the expression level of the proinflammatory cytokines such as interleukin-1β (IL-1β) and interferon-γ (IFN-γ), were studied by the quantitative real-time PCR. Flow cytometry analysis was performed on the effects of SLME on the detection of apoptotic and necrotic cells in T. gondii tachyzoites. Results: The SLME at the concentrations 75 and 150 µg/mL completely killed the tachyzoites after 2 hr of incubation. SLME at 25, 50, and 75 mg/kg/day increased the survival rate of infected mice by the sixth, seventh, and eighth days, respectively. SLME also significantly (p < 0.05) decreased the LPO and NO levels and upregulated the IL-1β and IFN-γ mRNA gene expression levels, whereas no considerable change was observed in the serum level of kidney and liver enzymes. Flow cytometry analysis revealed the prompted early and late apoptosis after exposure to T. gondii tachyzoites with various concentrations of SLME. Conclusion: We found the relevant in vitro anti-Toxoplasma effects of SLME against T. gondii. Moreover, the results confirmed the promising in vivo prophylactic effects of SLME. SLME provokes the innate immune system, induces apoptosis, modulates the proinflammatory cytokines, and inhibits hepatic injury in infected mice. With all these descriptions, further surveys are required to support these findings and elucidate this plant’s possible mechanisms of action.
Analisis Kelincahan dan Keseimbangan Terhadap Kemampuan Menggiring Bola pada Permaianan Sepakbola SDN 243 Jerrung II Sinjai
Authors: Mustafa Irvan , Fadlih Andi Muhammad 
Published: July 2023

Penelitian ini sendiri bertujuan untuk mengetahui adakah pengaruh dari kelincahan serta keseimbangan terhadap kemampuan dalam menggiring bola pada permainan sepakbola murid SDN 243 Jerrung II Kabupaten Sinjai. Metode yang digunakan yaitu menggunakan penelitian deskriptif kuantitatif dengan teknik pengumpulan data menggunakan teknik observasi atau pengamatan. Berdasarkan hasil analisis statistik menunjukkan koefisien determinasi sebesar R= 0,638 sedangan nilai R Square =0.407 atau kotribusi pengaruh secara bersama-sama 40.7% menjelaskan bahwa kelincahan (X1) memberikan pengaruh sebesar 40,7% , thitung =3,417 dengan nilai sig = 0.003(P < 0.05) berarti ada pengaruh kelincahan terhadap menggiring bola. Selanjutnya koefisien determinasi sebesar R= 0,735 sedangan nilai R Square =0.541 atau kotribusi pengaruh secara bersama-sama 54.1% menjelaskan bahwa keseimbangan (X2) memberikan pengaruh sebesar 54,1% dengan thitung =4,475 dengan nilai sig = 0.000(P < 0.05) berarti ada kaitan atau korelasi keseimbangan terhadap menggiring bola. Berdasarkan tabel dengan nilai determinasi (R Square) = 0.661 atau Korelasi secara bersama-sama sebesar 66.1% Sementara 33.9% disebabkan oleh faktor-faktor yang lain. Sehingga jika seseorang memiliki kelincahan dan keseimbangan yang baik akan diikuti dengan menggiring bola yang baik juga.
Pengembangan Bahan Ajar Materi Lempar Lembing Untuk Siswa Sekolah Dasar
Authors: Haqi Boihaqi - , Dimyati Dimyati , Susanto Ermawan , Hendrifadly Hendrifadly 
Published: July 2023

Tujuan dari Penelitian ini untuk mengembangkan bahan ajar materi lempar lembingUntuk siswa Sekolah Dasar yang memiliki validitas dan realibititas yang baik dapat dipergunakan dalam pembelajaran, metode dalam penelitian ini research and developmet, pengumpulan data dengan validasi desain, uji coba produk, validasi produk dan angket hasil penelitin menunjukkan, hasil persentase validasi dari validator diperoleh jawaban bahwa validator 1 pada umumnya sangat setuju (78,57%) dengan rancangan bahan ajar yang telah dikembangkan oleh peneliti,validator 2 semua setuju (100%) dengan isi bahan ajar yang dikembangkan oleh peneliti, dan validator 3 pada umumnya sangat setuju (51,79) dengan media bahan ajar yang telah dikembangkan oleh peneliti. Berdasarkan ketiga jawaban validator tersebut dapat dijelaskan bahwa ke empat bahan ajar yaitu :1) Lempar bola berekor, 2) Lempar Turbo,3) Lempar pipa dan 4) Lempar lembing Modifikasi yang dikembangkan sudah memiliki kelayakan untuk diajarkan.
Improvement of the thermoelectric performance of boron-doped silicon by blocking minority carrier diffusion on the p+/p interface
Authors: Sakamoto Momoka , Matsukawa Yuko , Sasaoka Rikuto , Minoshima Kohei , Nakamura Eisuke , Arita Makoto , Munetoh Shinji 
Published: July 2023

Abstract
A two-layer bulk Si material with different boron concentrations was prepared using spark plasma sintering to improve its thermoelectric performance by blocking minority carrier diffusion across its interfaces. The sintered two-layer sample (p+/p-Si) was cut to include the interface. Two monolayer samples (p+-Si, p-Si) were prepared for comparison. Seebeck coefficient mapping of the p+/p-Si surface by thermal probing confirmed a Seebeck coefficient gap between the two p-type Si layers, indicating that a band offset exists at the interface. When compared with the average resistivities and voltages for p+-Si and p-Si, the electrical resistivity in the p+/p-Si sample is almost identical, but the thermoelectric voltage is higher when the p+-part is heated more than the p-part. This indicates that bipolar carrier transport inhibition in the band offset improved the thermoelectric voltage. This bandgap engineering process and principle can be extended to other thermoelectric materials that can be processed via powder sintering.
Linking subjective financial well-being and compulsive buying behavior among college students: How Islamic financial literacy makes different
Authors: Karyatun Subur 
Published: July 2023

This study aims to enhance our understanding of the reciprocal association between subjective financial well-being and compulsive buying behavior while also considering the role of Islamic financial literacy as a boundary condition. The data for this research were collected in two phases from a sample of 266 students in Jakarta. The collected data were then analyzed using macro process version 4 to assess the proposed hypotheses. The study's findings confirm that subjective financial well-being and Islamic financial literacy negatively impact compulsive buying behavior. Moreover, the study reveals a subsequent influence of compulsive buying on future financial well-being, supporting a reciprocal relationship. Additionally, Islamic financial literacy plays a crucial role in mitigating the effect of financial well-being on compulsive buying behavior.
Public interest statements
Technological developments have brought changes in consumer behavior and sometimes have a negative impact on compulsive buying behavior. This research helps mitigate the effects of subjective financial well-being on compulsive behavior and how the two influence each other. In addition, students need to be given an understanding of Islamic financial literacy to control their buying behavior.
Article history
Received: 6/12/2023 | Revised: 7/4/2023 | Accepted: 7/4/2023 | Online First: 7/5/2023
Hipoplasia de esmalte tipo I, en pacientes durante la revisión habitual en una clínica universitaria
Authors: Canchari Pereyra Teresa Paola 
Published: July 2023

Introducción: La hipoplasia dental es una afección estructural a causa de un trastorno o formación incompleta de la matriz del esmalte, que macroscópicamente otorga al diente un aspecto blanquecino, sobre todo en el tipo I, característica muy parecida a la mancha blanca de la caries dental en su etapa inicial, la diferenciación entre ambas es su ubicación que comúnmente la hipoplasia no está relacionada con zonas susceptibles a la caries. El objetivo del presente es determinar la frecuencia de la hipoplasia dental en una población de 3 años a 64 años. Metodología: El estudio aplicado es cuantitativo, no experimental y tipo retrospectivo, en el que se revisaron 398 historias clínicas odontológicas, con la aplicación de una ficha de recolección se determine la presencia de hipoplasia de esmalte tipo I Resultados: de 398 pacientes presentaban hipoplasia tipo I un 19 %, de los cuales contaban con una distribución de 66 % en mujeres y para el sexo masculino de 34 %, presentándose en un 60 % en el maxilar superior, siendo la pieza 13 y 23 la que se presenta con mayor frecuencia. Discusión: La presencia de Hipoplasia de esmalte dental de tipo I, caracterizada por la presencia de mancha blanca, es una alteración estructural poco común en nuestra población de estudio, esta alteración está preferentemente en mujeres, en relación con su ubicación, se encuentra con mayor frecuencia en las piezas dentarias anterosuperiores en sus caras vestibulares, al afectar este sector involucra la estética, nos resulta importante su estudio para poder plantear soluciones preventivas más que rehabilitadoras, el deterioro de la estructura dental, ya que tener alteraciones estructurales son susceptibles a la caries dental e influyen drásticamente en la estética.
Upaya Meningkatkan Hasil Belajar Materi Pytagoras Menggunakan Pembelajaran STAD Kelas VIII UPTD SMPN 2 Sungai Kanan
Authors: Ernyda Ernyda 
Published: July 2023

Tujuan Penelitian ini adalah untuk meningkatkan hasil belajar materi pythagoras menggunakan pembelajaran kooperatif tipe STAD Siswa kelas VIII UPTD SMPN 2 Sungai Kanan. Subjek dalam penelitian ini adalah siswa sebanyak 23 orang, yang terdiri dari 12 siswa laki-laki dan 11 siswa perempuan. Metode yang digunakan pada penelitian ini adalah Penelitian Tindakan (Action Research) yang terdiri dari 2 (dua) siklus, dan setiap siklus terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Berdasarkan hasil penelitian tindakan bahwa Pembelajaran Kooperatif Tipe STAD dapat meningkatkan hasil belajar materi pythagoras Siswa Kelas VIII UPTD. SMPN 2 Sungai Kanan. pada siklus 1 untuk materi pythagoras dengan model pembelajaran, Pembelajaran Kooperatif Tipe STAD diperoleh nilai rata–rata siklus 1 sebesar 67 dengan ketuntasan 52% dengan nilai tertinggi adalah 100 terdapat 1 orang dan nilai terendah adalah 45 terdapat 2 orang. Pada siklus 2 hasil penelitian menunjukkan diperoleh nilai rata-rata siklus II sebesar 80,4 dengan nilai ketuntasan mencapai 91% nilai tertinggi adalah 100 terdapat 4 orang dan nilai terendah adalah 50 terdapat 2 orang. Dengan demikian penelitian meningkatkan hasil belajar materi Pytagoras di kelas VIII SMP Negeri 2 Sungai Kanan dinyatakan Tuntas dengan 2 siklus.
Analisis Fasilitas Pendidikan Sarana Dan Prasarana Pada Mts Hifzhil Qur’an Islamic Centre Medan
Authors: Ningratri Yuni Asri 
Published: July 2023

Tujuan penelitian ini adalah untuk menganalisis fasilitas pendidikan yang ada pada MTs Hifzhil Qur’an Islamic Centre Medan. Situasi sarana MTS Hifzhil Qur’an Islamic Centre Medan pada saat ini masih kurang optimal. Karena rasa yang kurang memiliki disetiap individu mengakibatkan sarana dan prasaranakurang dirawat dengan baik sehingga menciptakan situasi yang kurang optimal pada penggunaannya. Penelitian ini menggunakan metode deskriptif kualitatif. Hasil penelitian menunjukkan bahwa pengadaan sarana dan prasarana di MTs Hifzhil Quran Islamic Centre Medan yaitu dengan cara membeli dengan dana atau anggaran yang sudah ditetapkan. Dana pengadaan sarana dan prasarana yang didapat dari Yayasan dan dana BOS. Penggunaan sarana dan prasarana di MTs Hifzhil Quran Islamic Centre Medan memiliki aturan dan jadwal dalam penggunaan sarana dan prasarana yang tersedia, seperti penggunaan laboratorium IPA dan komputer.
Kinerja Keuangan PT Bank Rakyat Indonesia (Persero) Tbk Menggunakan Rasio Profitabilitas Tahun 2020-2022
Authors: Musadat Irfan Achmad , Sitorus Veronica Rohali 
Published: July 2023

Penelitian ini bertujuan untuk menganalisis kinerja keuangan menggunakan rasio profitabilitas pada perusahaan perbankan (Studi pada PT. Bank Rakyat Indonesia (Persero) Tbk tahun 2020- 2022). Sampel penelitian ini diambil dari perusahaan Bank Rakyat Indonesia. Data laporan keuangan diperoleh dari situs Bank Rakyat Indonesia (BRI). Metode yang digunakan dalam penelitian ini adalah metode analisis deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa kinerja keuangan perusahaan dalam kondisi baik jika dilihat melalui rasio NPM, ROA, dan ROE. Hasil penelitian menunjukkan bahwa NPM, ROA, dan ROE rata-rata NPM 20%, ROA 2%, dan ROE 10%, sehingga keuangan Bank Rakyat Indonesia (Persero) Tbk tahun 2020-2022 termasuk dalam kategori sehat. Produk Pembiayaan dan simpanan secara parsial berpengaruh terhadap profitabilitas. Demikian pula secara simultan jenis pembiayaan berpengaruh signifikan terhadap profitabilitas pada PT. Bank Rakyat Indonesia (Persero) Tbk tahun 2020- 2022.
PENGARUH ELECTRONIC WORD OF MOUTH (EWOM) MELALUI AKUN INSTAGRAM @MARASOE.ID TERHADAP SIKAP KONSUMEN
Authors: Hendriyani Mita , Putri Shinta Hartini , Reza Faisal 
Published: July 2023

Electronic word of mouth (EWOM) is a negative or positive statement made by actual, potential, or previous consumers who talk about this product and information is available to people via the internet media. One company that utilizes Electronic word of mouth (EWOM) is Marasoe by utilizing Instagram social media. The purpose of this study was to determine the effect of intensity, Valence of opinion and Content via Instagram @ Marasoe.id on consumer attitudes. The theory used is Theory Of Reasoned Action. The research method used is quantitative using a verification approach. The data were analyzed using the regression method to find the effect and the F test and the T test for simultaneous and partial hypothesis testing. The sampling technique used random sampling to 163 respondents. The results of this study indicate that simultaneously Electronic word of mouth (EWOM) through the Intagram account Marasoe.id affects consumer attitudes. Partially the intensity, Valence of opinion and Content through the Intagram account Marasoe.id affect consumer attitudes. The value of R is 0.794 and the coefficient of determination (R Square) is 0.631 which shows an effect of 63.1%, while the remaining 36.9% is explained by other causes. The regression coefficient for X is 0.410, indicating that every 1% increase in Electronic word of mouth (EWOM) units will increase consumer attitudes by 0.410.
PENGARUH PERENCANAAN PAJAK, FREE CASH FLOW DAN EARNING PRESSURE TERHADAP MANAJEMEN LABA PADA PERUSAHAAN MANUFAKTUR SUB SEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI PERIODE 2017- 2019
Authors: Meila Kaca Dian 
Published: July 2023

Tujuan dari penelitian ini adalah untuk mengetahui Pengaruh Perencanaan Pajak, Free Cash Flow dan Earning Pressure Terhadap Manajemen Laba Pada Perusahaan Manufaktur Sub Sektor Makanan dan Minuman Yang Terdaftar di BEI Periode 2017-2019. Objek dari penelitian ini adalah laporan keuangan perusahaan dengan atau karakteristik yaitu perencanaan pajak, free cash flow, earning pressure dan manajemen laba. Populasi dari penelitian ini adalah perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2019. Sampel yang digunakan dalam penelitian ini sebanyak 53 perusahaan manufaktur sub sektor makanan dan minuman. Teknik analisis data yang digunakan adalah regresi linier berganda. Berdasarkan uji statistik dan uji hipotesis dalam tingkat signifikansi α = 0,05 dapat dibuktikan bahwa secara parsial perencanaan pajak tidak berpengaruh terhadap manajemen laba, sedangkan free cash flow dan earning pressure berpengaruh signifikan terhadap manajemen laba. Secara simultan, perencanaan pajak, free cash flow dan earning pressure berpengaruh terhadap manajemen laba.
Sentence-final completion norms for 2925 Mexican Spanish sentence contexts
Authors: Angulo-Chavira Armando Quetzalcóatl , Castellón-Flores Alejandra Mitzi , Ciria Alejandra , Arias-Trejo Natalia 
Published: July 2023

AbstractSentence-final completion tasks serve as valuable tools in studying language processing and the associated predictive mechanisms. There are several established sentence-completion norms for languages like English, Portuguese, French, and Spanish, each tailored to the language it was designed for and evaluated in. Yet, cultural variations among native speakers of the same language complicate the claim of a universal application of these norms. In this study, we developed a corpus of 2925 sentence-completion norms specifically for Mexican Spanish. This corpus is distinctive for several reasons: Firstly, it is the most comprehensive set of sentence-completion norms for Mexican Spanish to date. Secondly, it offers a substantial range of experimental stimuli with considerable variability in terms of the predictability of word sentence completion (cloze probability/surprisal) and the level of uncertainty inherent in the sentence context (entropy). Thirdly, the syntactic complexity of the sentences in the corpus is varied, as are the characteristics of the final word nouns (including aspects of concreteness/abstractness, length, and frequency). This paper details the generation of the sentence contexts, explains the methodology employed for data collection from a total of 1470 participants, and outlines the approach to data analysis for the establishment of sentence-completion norms. These norms provide a significant contribution to fields such as linguistics, cognitive science, and machine learning, among others, by enhancing our understanding of language, predictive mechanisms, knowledge representation, and context representation. The collected data is accessible through the Open Science Framework (OSF) at the following link: https://osf.io/js359/?view_only=bb1b328d37d643df903ed69bb2405ac0.