bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiome–Metabolomics Analysis Reveals the Mechanism of Holothuria leucospilota Polysaccharides (HLP) in Ulcerative Colitis
Authors: Zhang Xin , Zhu Kexue , Zeng Shunjiang , Zheng Yuanping , Cao Jun , Li Chuan 
Published: March 2023

ScopeHolothuria leucospilota polysaccharides (HLP) are bioactive polysaccharides with immunomodulatory effects. This study aims to investigate the impact of HLP on dextran sodium sulfate (DSS)‐induced colitis in rats and further investigate the complex interactions between changes in intestinal microbiota, cometabolites, and intestinal inflammation under HLP intervention.Methods and resultsThe ulcerative colitis (UC) model of Sprague Dawley (SD) rats is established by a normal diet with 3%DSS. The effects of HLP on UC are studied by gavage of different doses of HLP for 2 weeks. The results show that HLP alleviate the inflammation of UC and reduce histological damage and secretion of tumor necrosis factor‐α (TNF‐α), IL‐6, IL‐1β, and IL‐10. After HLP treatment, the intestinal flora of UC rats is regulated, and the flora diversity is restored. Fecal metabolomics analysis reveal the modulatory effects of HLP on amino acid metabolism, antimicrobial peptide anabolism, and energy metabolism in rats with colitis. Correlation analysis of microbial and intestinal metabolites reveals the potential mechanism of HLP affecting colitis.ConclusionHLP repair the intestinal compartment's metabolic disorder by regulating intestinal flora's structure and alleviating colonic mucosal injury and inflammation in colitis rats.
Encapsulated Colorimetric Indicators used as Additives During the Polymerization of Smart Polyethylene
Authors: Heck Cesar A. , dos Santos João Henrique Z. 
Published: March 2023

AbstractA number of colorimetric pH indicators (phenolphthalein, bromocresol green, 4‐nitrophenol, phenol red, and bromothymol blue) are encapsulated within silica particles via an acid‐catalyzed sol–gel process. The fabricated indicator is added during ethylene polymerization with a metallocene (Cp2ZrCl2) catalyst. Introduction of the indicator into the silica matrix affects the surface area, probably by partially blocking some of the pores. The encapsulated pH indicator reduces the catalytic activity by up to 17%, whereas adding a solution of the indicator reduced the catalytic activity by up to 34%. The crystallinities of the samples containing the silica‐encapsulated pH indicators are lower than those of the samples to which the pH indicator is added in solution form. The prepared encapsulated colorimetric pH indicators are analyzed by diffuse reflectance UV‐vis spectroscopy. The measured color values are distributed according to the CIE Lab lightness psychometric color space. Addition of the indicator in solution form (free) to the ethylene polymerization reaction does not result in indicator activity in acidic or alkaline media. The pH indicators incorporated into the polyethylene show color changes when exposed to acidic and alkaline media. Samples to which the unencapsulated pH indicators (free) are added exhibit lower catalytic activities and higher crystallinities than the samples containing the encapsulated pH.
Augmented reality and nonprofit marketing during the COVID‐19 pandemic: AR factors that influence community participation and willingness to contribute to causes
Authors: Yoo Seung‐Chul , Drumwright Minette E. , Piscarac Diana 
Published: March 2023

AbstractThis study used augmented reality (AR) to test the effects of perceived social presence, perceived media richness, media empathy and social capital on intentions to participate in prosocial, community‐oriented behaviors in the context of the COVID‐19 pandemic, which appeared to be rife with fear. Specifically, a structural model was employed to assess the hypothesized relationships based on questionnaire data from 476 respondents, who were divided into high and low fear groups. The findings revealed that perceived media richness and social presence both had a significant influence on media empathy, which in turn affected users' perceptions of social capital. Social capital predicted users' community participation intentions, which included intentions to donate. The paths from perceived social presence and perceived media richness to social capital were not significant, and media empathy did not directly influence prosocial, community participation intentions. There were no significant differences between the high and low COVID‐19 fear groups. Overall, this study confirmed the importance of leveraging media richness and social presence to create media content designed to prompt users to identify with those who are negatively affected by the cause, so that media empathy will be boosted. Media empathy should be increased in a manner that leads users to feel connected to a larger community, so that perceptions of social capital will be boosted and will lead to prosocial, community participation activities and donations to the cause.
The frequency of psychiatric disorder co‐morbidities in patients with fibromyalgia: A cross‐sectional study in Iran
Authors: Sadr Sara , Mobini Maryam , Tabarestani Mohammad , Islami Parkoohi Parisa , Elyasi Forouzan 
Published: March 2023

AbstractAimThis study aimed to investigate psychiatric disorders in Iranian female patients with fibromyalgia (FM).DesignFemale patients, newly diagnosed with FM, were interviewed by a psychiatrist for psychiatric assessments during a 2‐year period.MethodsThe diagnosis of the psychiatric disorders was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5), and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI).ResultsIn total, 159 patients with the mean age of 42.15 ± 9.89 were recruited in this study. Over 92% of the cases were also diagnosed with at least one type of psychiatric disorder. Sleep disorders (SDs, 90.57%), mood disorders (MDs, 52.83%), personality disorders (PDs, 40.25%) and anxiety disorders (ADs, 16.98%) were the most prevalent diagnoses among these patients. The logistic regression results correspondingly showed that suffering from Cluster‐B PDs was associated with a higher prevalence rate of somatic symptom disorders (SSDs), with a p‐value of 0.019 and an odds ratio (OR) of 2.7.
Improved alginate‐based films by Ylang‐ylang (Cananga odorata L) oil incorporation
Authors: Nkede Francis Ngwane , Wardana Ata Aditya , Phuong Nguyen Thi Hang , Xirui Yan , Koga Arisa , Wardak Mohammad Hamayoon , Tanaka Fumina , Tanaka Fumihiko 
Published: March 2023

AbstractIn this study, edible films composed of 1% (w/v) alginate (Alg) and ylang‐ylang essential oil (YYEO, 0.1%, 0.3%, and 0.5%) were fabricated and characterized for the first time. The alginate suspension viscosity increased significantly from 255.8 to 290.5 Cp, with a corresponding significant film thickness increase from 0.029 to 0.043 mm. There was also a significant decrease in moisture content (MC%) from 30.22 to 23.93%. Scanning electron microscopy and atomic force microscopy analyses showed an increased Alg/YYEO film roughness. The presence of YYEO in the alginate film was confirmed by Fourier transform infrared spectroscopy and confocal laser scanning microscopy. YYEO addition induced no significant change in total color difference (ΔE). There was a decrease in tensile strength and a significant (p < 0.05) increased elongation at break (EAB%) by 83.11%. The Alg/0.3% YYEO film demonstrated improved water vapor permeability compared with the other films. The Alg/0.5% YYEO film had strong antioxidant scavenging properties (27.94%), and an opacity of 3.60 A/mm. Both the Alg/0.3% YYEO and 0.5% YYEO coating solutions greatly improved antifungal properties against Botrytis cinerea. Therefore, alginate films incorporating YYEO are viable materials for edible films and coatings in fresh produce packaging.
Composite electrolyte with polyethylene oxide and metal–organic framework for lithium‐ion conduction
Authors: Zerin Nagma , Yin Xinyang , Maranas Janna K. 
Published: March 2023

AbstractPolyethylene oxide based solid polymer electrolytes (SPEs) are safer alternatives to the current flammable liquid electrolytes used in lithium‐ion batteries. Lithium ions are typically thought to conduct through the amorphous regions of SPEs with the aid of polymer segmental motion, which is correlated with the glass transition temperature (Tg). The ionic conductivity is generally increased by making the polymer more flexible (decreasing Tg) and/or by increasing the amorphous regions of the SPE, at the cost of compromising its stiffness. This trade‐off makes it impossible to optimize both ionic conductivity and stiffness of SPEs. By incorporating a metal–organic framework (MOF) nanowhisker with the composition EO:Li = 6:1 [EO = ether oxygen, Li = lithium], we synthesized a unique composite electrolyte. We observed an atypical conductivity mechanism in this composite electrolyte, where lithium ions conduct through the crystalline regions without decreasing Tg or increasing amorphous fraction. The room‐temperature ionic conductivity of the 6:1 polymer electrolyte increased by almost 400% when 2 wt% MOF nanowhisker was added. Our results supported the potential of a composite electrolyte, which enables simultaneous improvement in both conductivity and stiffness.
Social support and childhood cancer survivors: A systematic review (2006–2022)
Authors: Deegan Avril , Brennan Ciara , Gallagher Pamela , Lambert Veronica , Dunne Simon 
Published: March 2023

AbstractObjectiveResearch has indicated that social support may play a protective role in the face of stress and help children and adolescents cope with the demands and challenges they face on a daily basis during their cancer journey. However, social support tends to reduce over time as survivors overcome their illness despite its ongoing importance even years after treatment has finished. The current review aimed to systematically examine existing evidence on social support in child and adolescent cancer survivors.MethodsFive databases (PsychINFO, CINAHL, EMBASE, PubMed and Web of Science) were searched systematically to identify quantitative studies which explored social support from the perspective of child and adolescent cancer survivors aged 18 years or younger.ResultsA total of 10 studies met the eligibility criteria for inclusion. Findings from the review indicate that family and friends, particularly parents, are important sources of social support for survivors. Social support was positively related to posttraumatic growth, school re‐entry and physical activity, and negatively related to psychological stress, depression, anxiety and stress. Furthermore, findings relating to gender, age and group differences were mixed. A number of methodological concerns were identified in the reviewed studies including small sample sizes, as well as a lack of consistency in the measurement of social support.ConclusionsFuture studies of social support for child and adolescent cancer survivors need to address these shortcomings to help inform care and support interventions promoting social support in survivors.
Proton therapy for high‐risk prostate cancer: Results from the Proton Collaborative Group PCG 001‐09 prospective registry trial
Authors: Hasan Shaakir , Lazarev Stanislav , Garg Madhur , Gozland Rachel , Chang John , Hartsell William , Chen Jonathan , Tsai Henry , Vargas Carlos , Simone Charles B. , Gorovets Daniel 
Published: March 2023

AbstractBackgroundData for proton therapy in high‐risk prostate cancer (HRPC) are limited. Using the Proton Collaborative Group prospective registry, we evaluated outcomes for HRPC patients treated with proton therapy.MethodsA totsl of 605 men with localized HRPC treated with proton therapy from 8/2009 to 3/2019 at nine institutions were selected. Outcomes examined included freedom from progression (FFP), metastasis free survival (MFS), overall survival (OS), and toxicity. Multivariable cox/binomial regression models were used to assess predictors of FFP and toxicity.ResultsMedian age was 71 years. Gleason grade groups 4 (49.4%) and 5 (31.7%) were most common, as were clinical stage T1c (46.1%) and cT2 (41.3%). The median pretreatment prostate specific antigen (PSA) was 9.18 and median International Prostate Symptom Score (IPSS) was 6. Androgen deprivation therapy was given in 63.6%. Median dose was 79.2 GyE in 44 fractions. Pelvic lymph nodes were treated in 58.2% of cases. Pencil beam scanning was used in 54.5%, uniform scanning in 38.8%, and a rectal spacer in 14.2%. At a median followup of 22 months, the 3‐ and 5‐year FFP were 90.7% and 81.4%, respectively. Five‐year MFS and OS were 92.8% and 95.9%, respectively. Independent correlates of FFP included Gleason ≥8, PSA > 10, and cT2 (all p < 0.05). No grade 4 or 5 adverse events were reported. There were 23 (5%) grade 2 and 0 grade 3 gastrointestinal events. Prevalence of late grade 3, late grade 2, acute grade 3, and acute grade 2 genitourinary toxicity was 1.7%, 5.8%, 0%, and 21.8%, respectively. Prevalence of grade 2 and 3 erectile dysfunction at 2 years was 48.4% and 8.4%, respectively.ConclusionsIn the largest series published to date, our results suggest early outcomes using proton therapy for HRPC are encouraging for both safety and efficacy. Further evaluation is needed to determine if an advantage exists to use protons over other radiation techniques in this population.
The addition of dydrogesterone improves the outcomes of pregnant women with low progesterone levels when receiving vaginal progesterone alone as luteal support in HRT‐FET cycles
Authors: Toriumi Rena , Horikawa Michiharu , Sato Chie , Shimamura Nagisa , Ishii Rena , Terashima Michiru , Hamada Michiko , Tachibana Naoyuki , Taketani Yuji 
Published: March 2023

AbstractPurposeVaginal progesterone (VP) alone has been used as luteal support (LS) in HRT‐FET cycles without measuring serum progesterone concentrations (SPC) because it can achieve adequate intrauterine progesterone levels. However, several reports showed that the co‐administration of progestin produced better outcomes than VP alone. We tried to address this discrepancy, focusing on SPC.MethodsVP was given to 180 women undergoing HRT‐FET. We measured SPC when pregnancy was diagnosed on day 14 of LS. We compared assisted reproductive technology outcomes between VP alone versus VP + dydrogesterone (D).ResultsWhen using VP alone, average SPC in the miscarriage cases (9.6 ng/mL) were significantly lower compared with the ongoing pregnancy (OP) cases (14.7 ng/mL). The cut‐off value for progesterone, 10.7 ng/mL, was a good predictor for the subsequent course of the pregnancy. Of 76 women receiving D ± VP from the start of LS and achieving a pregnancy, the numbers of OP were 44 (84.6%) in SPC ≥ 10.7 ng/mL and 20 (83.3%) in SPC ≤ 10.7 ng/mL with no significant difference.ConclusionVP alone resulted in lower SPC in some pregnant women in HRT‐FET cycles and exhibited a lower OP rate. The co‐administration of D improved an OP rate of low progesterone cases to the level comparable with non‐low progesterone cases.
Reproducibility as a service
Authors: Wonsil Joseph , Boufford Nichole , Agrawal Prakhar , Chen Christopher , Cui Tianhang , Sivaram Akash , Seltzer Margo 
Published: March 2023

AbstractRecent studies demonstrated that the reproducibility of previously published computational experiments is inadequate. Many of these published computational experiments never recorded or preserved their computational environment, including packages installed in the language, libraries installed on the host system, and file locations. Researchers have created reproducibility tools to help mitigate this problem, but these tools assume the experiment currently executes. Thus, these tools do not facilitate reproducibility of the large number of published experiments. This situation is not improving; researchers continue to publish without using reproducibility tools. We define a framework to distinguish between actions taken by a researcher to facilitate reproducibility in the presence of a computational environment and actions taken by a researcher to enable reproduction of an experiment when that environment has been lost to clarify the gap between what existing reproducibility tools are capable of and what is required to reproduce published experiments. The difference between these approaches lies in the availability of a computational environment. Researchers that provide access to the original computational environment perform proactive reproducibility, while those who do not enable only retroactive reproducibility. We present Reproducibility as a Service (RaaS), which is, to the best of our knowledge, the first reproducibility tool explicitly designed to facilitate retroactive reproducibility. We demonstrate how RaaS fixes many common errors found in R scripts on Harvard's Dataverse and preserves a recreated computational environment. Finally, we discuss how a retroactive reproducibility service such as RaaS is also helpful as an ‘artifact evaluation assistant’ in a journal's publication pipeline.
Efficient implementation of image representation, visual geometry group with 19 layers and residual network with 152 layers for intrusion detection from UNSW‐NB15 dataset
Authors: Sallam Youssef F. , Abd El‐Nabi Samy , El‐Shafai Walid , Ahmed Hossam El‐din H. , Saleeb Adel , El‐Bahnasawy Nirmeen A. , Abd El‐Samie Fathi E. 
Published: March 2023

AbstractThe Internet offers humanity many distinctive and indispensable services, whether for individuals or for institutions and companies. This great role has attracted the Internet attackers to develop their mechanisms to capture and obtain the data by illegal methods. This growth in the number of cyber‐attacks made scientists in a real challenge, to find advanced methods to face this danger. Due to the shortcomings of traditional data security means such as firewalls, encryption, and so forth, the motivation became to develop alternative systems to detect smart attacks. Intrusion detection systems (IDSs) have made remarkable progress in cyber‐security. They monitor the traffic in real time and continuously to detect the network attacks, giving alerts to the network administrator. In this article, two IDSs are introduced based on principles of transfer learning (TL) with convolutional neural networks. Our systems are built using the visual geometry group (VGG19) and residual network with 152 layers (ResNet152). UNSW‐NB15 intrusion detection dataset is used to evaluate the models. The proposals achieve high levels of precision, recall, and F1_score as 99%, 99%, and 99%, respectively. These achievements prove the efficiency of the proposed models in capturing cyber‐attacks with low alert rates.
Using a design‐based approach to develop a checklist for evaluating preservice teacher learning materials
Authors: Shieh Jin‐Jy , Reynolds Barry Lee , Ha Xuan Van 
Published: March 2023

AbstractTeacher educators drive preservice teachers' learning about teaching particularly through feedback. The learning materials produced by preservice teachers also play a crucial role in English language teacher training but may not be receiving the necessary attention in teacher education programs. Preservice teachers lack formal teaching experiences, which may result in their overemphasizing material delivery while underemphasizing material suitability. Providing teacher educators with criteria for evaluating learning materials developed by preservice teachers could aid in their providing quality formative feedback. Therefore, this study was designed to construct a research‐based contextualized evaluation checklist for learning materials. Adopting a systematic yet flexible design‐based method allowed for the integration of design and intervention to develop a solution for this targeted educational problem. The researchers adopted a three‐phase process for this study: analysis and exploration of a teacher educator's needs and extant literature on learning materials; design and construction; and evaluation and reflection. Learning materials designed by a preservice teacher were used to pilot the checklist. The results showed a need for refinement to form the final evaluation checklist. The checklist can be used by teacher educators for preservice teacher evaluation purposes or by preservice teachers as a quality check.
How college student leaders of color engage in controversy with courage while enacting social justice leadership
Authors: Chang Ting‐Han , Acosta Dominique Orfano 
Published: March 2023

AbstractThis article presents one qualitative study that examined college student leaders of color's social justice leadership and their engagement in controversy and difficult conversations about issues of injustices. Specifically, this article applies the controversy with courage element from the social action, leadership, and transformation model (SALT) to address how and why 16 college student leaders were engaged in these conversations and the connection between partaking in controversy and enacting social justice leadership.
Understanding the role of coalescence in social justice leadership development
Authors: Boey Leslie W. , Cruz Tabatha , Fulton Leah N. , Mitchell Tania D. 
Published: March 2023

AbstractThis article highlights the important role of coalescence in preparing leaders to engage in a diverse society. The authors draw on intersectional and critical frames to understand coalescence. Using supporting data from a study on BIPOC student leaders, the authors demonstrate the ways in which students build capacity for coalescence and recommend strategies to cultivate environments that promote this work.
An Efficient Threshold Access-Structure for RLWE-Based Multiparty Homomorphic Encryption
Authors: Mouchet Christian , Bertrand Elliott , Hubaux Jean-Pierre 
Published: March 2023

AbstractWe propose and implement a multiparty homomorphic encryption (MHE) scheme with a $$t$$
t
-out-of-$$N$$
N
-threshold access-structure that is efficient and does not require a trusted dealer in the common random string model. We construct this scheme from the ring-learning-with-error assumptions and as an extension of the MHE scheme of Mouchet et al. (PETS 21). By means of a specially adapted share re-sharing procedure, this extension can be used to relax the $$N$$
N
-out-of-$$N$$
N
-threshold access-structure of the original scheme into a $$t$$
t
-out-of-$$N$$
N
-threshold one. This procedure introduces only a single round of communication during the setup phase, after which any set of at least t parties can compute a t-out-of-t additive sharing of the secret-key with no interaction; this new sharing can be used directly in the scheme of Mouchet et al. We show that, by performing Shamir re-sharing over the MHE ciphertext-space ring with a carefully chosen exceptional set, this reconstruction procedure can be made secure and has negligible overhead. Moreover, it only requires the parties to store a constant-size state after its setup phase. Hence, in addition to fault tolerance, lowering the corruption threshold also yields considerable efficiency benefits, by enabling the distribution of batched secret-key operations among the online parties. We implemented and open-sourced our scheme in the Lattigo library.