bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI-Based Radiomics Approach Predicts Tumor Recurrence in ER + /HER2 − Early Breast Cancer Patients
Authors: Chiacchiaretta Piero , Mastrodicasa Domenico , Chiarelli Antonio Maria , Luberti Riccardo , Croce Pierpaolo , Sguera Mario , Torrione Concetta , Marinelli Camilla , Marchetti Chiara , Domenico Angelucci , Cocco Giulio , Di Credico Angela , Russo Alessandro , D’Eramo Claudia , Corvino Antonio , Colasurdo Marco , Sensi Stefano L. , Muzi Marzia , Caulo Massimo , Delli Pizzi Andrea 
Published: January 2023

AbstractOncotype Dx Recurrence Score (RS) has been validated in patients with ER + /HER2 − invasive breast carcinoma to estimate patient risk of recurrence and guide the use of adjuvant chemotherapy. We investigated the role of MRI-based radiomics features extracted from the tumor and the peritumoral tissues to predict the risk of tumor recurrence. A total of 62 patients with biopsy-proved ER + /HER2 − breast cancer who underwent pre-treatment MRI and Oncotype Dx were included. An RS > 25 was considered discriminant between low-intermediate and high risk of tumor recurrence. Two readers segmented each tumor. Radiomics features were extracted from the tumor and the peritumoral tissues. Partial least square (PLS) regression was used as the multivariate machine learning algorithm. PLS β-weights of radiomics features included the 5% features with the largest β-weights in magnitude (top 5%). Leave-one-out nested cross-validation (nCV) was used to achieve hyperparameter optimization and evaluate the generalizable performance of the procedure. The diagnostic performance of the radiomics model was assessed through receiver operating characteristic (ROC) analysis. A null hypothesis probability threshold of 5% was chosen (p < 0.05). The exploratory analysis for the complete dataset revealed an average absolute correlation among features of 0.51. The nCV framework delivered an AUC of 0.76 (p = 1.1∙10−3). When combining “early” and “peak” DCE images of only T or TST, a tendency toward statistical significance was obtained for TST with an AUC of 0.61 (p = 0.05). The 47 features included in the top 5% were balanced between T and TST (23 and 24, respectively). Moreover, 33/47 (70%) were texture-related, and 25/47 (53%) were derived from high-resolution images (1 mm). A radiomics-based machine learning approach shows the potential to accurately predict the recurrence risk in early ER + /HER2 − breast cancer patients.
Global invasion history and native decline of the common starling: insights through genetics
Authors: Stuart Katarina C. , Hofmeister Natalie R. , Zichello Julia M. , Rollins Lee A. 
Published: January 2023

AbstractFew invasive birds are as globally successful as the Common or European Starling (Sturnus vulgaris). Native to the Palearctic, the starling has been intentionally introduced to North and South America, South Africa, Australia, and the Pacific Islands, enabling us to explore species traits that may contribute to its invasion success. Coupling the rich studies of life history and more recent explorations of genomic variation among invasions, we illustrate how eco-evolutionary dynamics shape the invasion success of this long-studied and widely distributed species. Especially informative is the comparison between Australian and North American invasions, because these populations colonized novel ranges concurrently and exhibit shared signals of selection despite distinct population histories. In this review, we describe population dynamics across the native and invasive ranges, identify putatively selected traits that may influence the starling’s spread, and suggest possible determinants of starling success world-wide. We also identify future opportunities to utilize this species as a model for avian invasion research, which will inform our understanding of species’ rapid evolution in response to environmental change.
Antiplatelet Agents and Oral Anticoagulant Use in Patients with Atrial Fibrillation and Carotid Artery Disease After First-Time Ischaemic Stroke
Authors: Harrison Stephanie L. , Buckley Benjamin J.R. , Lane Deirdre A. , Fazio-Eynullayeva Elnara , Underhill Paula , Hill Andrew , Werring David J. , Lip Gregory Y.H. 
Published: January 2023

Abstract
Introduction
People with atrial fibrillation (AF) frequently have competing mechanisms for ischaemic stroke, including extracranial carotid atherosclerosis. The objective of this study was to determine associations between use of oral anticoagulants (OACs) plus antiplatelet agents (APA) after ischaemic stroke and outcomes for patients with AF and carotid artery disease.

Patients and Methods
A retrospective cohort study was conducted. Participants receiving OACs with or without APA were propensity score–matched for age, sex, ethnicity, co-morbidities and presence of cardiac and vascular implants and grafts. Outcomes were 1-year mortality, recurrent stroke and major bleeding.

Results
Of 5708 patients, 24.1% (n=1628) received non-vitamin K antagonist OACs (NOACs) with no APA, 26.0% (n=1401) received NOACs plus APA, 20.7% (n=1243) received warfarin without APA and 29.2% (n=1436) received warfarin plus APA. There was no significant difference in risk of recurrent stroke between the groups. Compared to receiving NOACs without APA, receiving warfarin plus APA was associated with a higher risk of mortality (hazard ratio (HR) 1.51 (95% confidence interval (CI) 1.20, 1.89)) and major bleeding (HR 1.66 (95% CI 1.40, 1.96)). Receiving NOACs plus APA was also associated with a higher risk of major bleeding compared to NOACs without APA (HR 1.27 (95% CI 1.07, 1.51), respectively).

Conclusions
The results suggest for patients with AF and carotid artery disease after ischaemic stroke, receiving NOACs without APA is associated with a lower risk of major bleeding with no negative impact on recurrent stroke or mortality. Evidence from randomised trials is needed to confirm this finding.
Virtual element method for mixed-mode cohesive fracture simulation with element split and domain integral
Authors: Choi Habeun , Chi Heng , Park Kyoungsoo 
Published: January 2023

AbstractWe present a computational framework for mixed-mode cohesive fracture simulation based on the virtual element method (VEM). To represent an arbitrary crack path, the element splitting scheme is developed on a polygonal mesh to capitalize its flexibility in element shape. For the accurate evaluation of a crack-tip stress field and crack propagation direction, the virtual grid-based stress recovery scheme is tailored for VEM in conjunction with the maximum strain energy release rate criterion. The mixed-mode fracture examples are illustrated to validate the accuracy and robustness of the proposed computational scheme. Numerical results demonstrate that the domain integral method with the stress recovery scheme captures an accurate crack path without oscillation under the biaxial tensile stress state. Furthermore, the computed cracks using the element splitting scheme show that smooth and curved patterns on polygonal elements are in good agreement with the experimental results.
Application of feature-based molecular networking in the field of algal research with special focus on mycosporine-like amino acids
Authors: Zwerger Michael J. , Hammerle Fabian , Siewert Bianka , Ganzera Markus 
Published: January 2023

AbstractMarine red algae have been known as an excellent source for natural sunscreens and antioxidants for a long time, which outlines their potential for various medical and cosmeceutical applications. This is due to their synthesis of unique secondary metabolites to shield themselves from high levels of UV-A and -B radiation encountered in their natural habitats. In this study, a comprehensive and contemporary way for the detection, visualization, and dereplication of algal natural products with special focus on mycosporine-like amino acids (MAAs) is shown, employing HR-MS/MS metabolomics. 33 crude algal extracts were explored using ultra-high-performance liquid chromatography (UHPLC) hyphenated to orbitrap high-resolution tandem mass spectroscopy (HRMS2). Acquired raw data, subjected to pretreatment and spectral organization, could subsequently be implemented in the Global Natural Products Social (GNPS) workflow, whereby a feature based molecular network (FBMN) was created and visualized in Cytoscape. This FBMN was matched against an in-house as well as open source library on the GNPS platform and additionally enhanced by chemotaxonomic classification software and spectra of standard MAAs, as well as further information layers covering e.g. physicochemical properties, taxonomy, and fragmentation behavior. Based on the integration of the latestin silicoannotation tools (SIRIUS, CANOPUS, MSNovelist) as well as already published fragmentation patterns of MAAs, structures for known compounds could be corroborated as well as those for novel substances proposed. This offers an interesting and state-of-the-art approach towards the identification and classification of known and new MAAs.
The Influence of Parent- and Adult Child-level Factors on Intergenerational Relationship Quality: A Study of Chinese Families with Multiple Children in Hong Kong
Authors: Liu Chang , Bai Xue 
Published: January 2023

AbstractIntergenerational relationships have become increasingly crucial for maintaining well-being in aging families. Under a changing sociocultural background, families in Hong Kong increasingly exhibit diverse intergenerational relationships and functioning. Focusing on families with mutiple children, this study investigated how the characteristics of parents and their adult children jointly affect different domains of intergenerational relationship quality. A two-stage stratified random sampling design was adopted. Face-to-face questionnaire interviews were conducted between November 2016 and March 2017 with 1,001 Hong Kong residents aged ≥ 50 years. Data of 612 parents and 1,745 adult children were included for analysis. Hierarchical linear modeling was performed to examine child- and parent-level correlates of intergenerational relationship quality. Parents who were female, were married, had higher self-perceived economic status, owned a house, and had fewer depressive symptoms, exhibited higher intergenerational relationship quality. Parents’ age was positively related to affectual closeness, whereas their educational level was negatively related to both affectual closeness and conflict. More favorable intergenerational relationships were reported by aging parents whose adult children were younger, female, and married. Children with higher educational levels exhibited higher levels of both affectual closeness and conflict with their parents. Moreover, affectual closeness was found to be transmitted between generations. The findings can help improve awareness of the factors affecting the different domains of intergenerational relationships, thus informing the development of targeted services and interventions to promote family relationships and well-being.
Exploring the Impact of Covid-19-Related Perceptions on Psychological Distress and Quality of Life in an International Gastrointestinal Cohort Over Time Guided by the Common Sense Model
Authors: Knowles Simon R. , Möller Stephan P. , Stengel Andreas , Mikocka-Walus Antonina , Ferreira Nuno , Trindade Inês A. , Mokrowiecka Anna , Burisch Johan , Barreiro-de Acosta Manuel , Bernstein Charles N. , Lo Bobby , Skvarc David 
Published: January 2023

AbstractThe aim of this longitudinal study was to examine changes in COVID-19 and illness-related perceptions, gastrointestinal symptoms, coping, catastrophising, psychological distress, and QoL during the COVID-19 pandemic. A total of 831 adults with a gastrointestinal condition completed an online questionnaire at baseline (May—October 2020). Of those, 270 (32.5%) participants (85.2% female, mean age = 47.3 years) provided follow-up data (March—May 2021). Repeated-measures multiple analysis of variance and a cross-lagged panel model were used to test the study hypotheses. Gastrointestinal symptoms and COVID-19 perceptions at follow-up were strongly predicted by their baseline values, while illness perceptions were predicted by baseline gastrointestinal symptoms. Cross-lagged relationships indicated a reciprocal relationship between gastrointestinal symptoms and psychological distress. Moreover, gastrointestinal symptoms had substantial predictive utility, strongly predicting future gastrointestinal symptoms, and to a lesser extent, more negative illness perceptions, greater psychological distress, and greater use of adaptive coping strategies across time.
Effect of Scanning Acceleration on the Leakage Signal in Magnetic Flux Leakage Type of Non-destructive Testing
Authors: Zhang Lintao , Cameron Ian M. , Ledger Paul D. , Belblidia Fawzi , Pearson Neil R. , Charlton Peter , Sienz Johann 
Published: January 2023

AbstractThis work investigates the influence of acceleration on the leakage signal in magnetic flux leakage type of non-destructive testing. The research is addressed through both designed experiments and simulations. The results showed that the leakage signal, represented by using peak to peak value, decreases between 15.1% and 26.6% under acceleration. The simulation results indicated that the main reason for the decrease is due to the difference in the distortion of the magnetic field for cases with and without acceleration, which is the result of the different eddy current distributions in the specimen. The findings will help to allow the optimisation of a magnetic flux leakage system to ensure that main defect features can be measured more accurately during the machine acceleration phase of scanning. It also shows the importance of conducting measurements at constant velocity, wherever possible.
Comparative study of Eu and U sorption on cementitious materials in the presence of organic substances
Authors: Burešová Marta , Kittnerová Jana , Drtinová Barbora 
Published: January 2023

AbstractA comparative study of the sorption behavior of europium, a chemical analogue of trivalent actinides, and uranium was performed on hydrated cement paste (HCP) CEM I and calcium-silicate-hydrates (CSH) phase. Kinetic experiments proved that Eu sorption is faster than that of U depending on the phase ratio L/S and the sorption material, whereas EDTA has no significant effect. Same conclusions can be made for equilibrium experiments with HCP and U while with Eu EDTA clearly influenced the distribution ratio Rd with sorption reduction factor (SRF) below 0.5. Uranium sorption on CSH compared to HCP is higher with SRF above 1.2.
What if, and when? Conditionals, tense, and branching time
Authors: Rumberg Antje , Lauer Sven 
Published: January 2023

AbstractIndicative conditionals with present tense antecedents can have ‘shifted’ readings that are unexpected given the semantic behavior of the tenses outside of conditionals. In this paper, we compare two accounts of this phenomenon due to Kaufmann (J Semant 22(3):231–280, 2005) and Schulz (SALT XVIII, pp. 694–710, 2008), by reconstructing them in the framework of branching time. We then propose a novel account of indicative conditionals based on the branching time semantics suggested in Rumberg (J Logic Lang Inf 25(1):77–108, 2016), viz. transition semantics. We show that not only is the account of ‘shifted’ readings with present tense antecedents within this semantics very natural, but it also is empirically superior to its rivals in some respects.
Does top management team diversity affect accounting quality? Empirical evidence from Germany
Authors: Schumann Felix , Thun Toni W. , Dauth Tobias , Zülch Henning 
Published: January 2023

AbstractEarnings management decisions and ineffective monitoring activities have contributed to financial accounting scandals and reduced confidence in firms’ reporting quality among potential investors, lenders and other creditors. The implementation of an effective top management team (TMT) is considered essential in this context. It is well known that top managers have considerable discretion over firms’ financial reporting since they choose whether and how to manage earnings. However, research has yet to establish the relationship between top managers’ diversity attributes and firms’ earnings management levels. Therefore, this study analyses whether and how top managers’ nationality, gender and age diversity are associated with accounting quality. Based on a sample of German DAX 30 listed firms from 2011 to 2018, we found that diversity in TMT nationality and gender have a positive impact on accounting quality. This relationship is context-dependent and negatively moderated by the tenure of the chief financial officer. Our findings provide novel insights on accounting quality for practitioners such as investors, regulators and stock corporations. The implications of this study further advance the academic debate on diversity in TMTs and its effects on earnings management.
On the rigorous derivation of the incompressible Euler equation from Newton’s second law
Authors: Rosenzweig Matthew 
Published: January 2023

AbstractA long-standing problem in mathematical physics is the rigorous derivation of the incompressible Euler equation from Newtonian mechanics. Recently, Han-Kwan and Iacobelli (Proc Am Math Soc 149:3045–3061, 2021) showed that in the monokinetic regime, one can directly obtain the Euler equation from a system of N particles interacting in $${\mathbb {T}}^d$$

T

d

, $$d\ge 2$$

d
≥
2

, via Newton’s second law through a supercritical mean-field limit. Namely, the coupling constant $$\lambda $$
λ
in front of the pair potential, which is Coulombic, scales like $$N^{-\theta }$$

N

-
θ

for some $$\theta \in (0,1)$$

θ
∈
(
0
,
1
)

, in contrast to the usual mean-field scaling $$\lambda \sim N^{-1}$$

λ
∼

N

-
1

. Assuming $$\theta \in (1-\frac{2}{d(d+1)},1)$$

θ
∈
(
1
-

2

d
(
d
+
1
)

,
1
)

, they showed that the empirical measure of the system is effectively described by the solution to the Euler equation as $$N\rightarrow \infty $$

N
→
∞

. Han-Kwan and Iacobelli asked if their range for $$\theta $$
θ
was optimal. We answer this question in the negative by showing the validity of the incompressible Euler equation in the limit $$N\rightarrow \infty $$

N
→
∞

for $$\theta \in (1-\frac{2}{d},1)$$

θ
∈
(
1
-

2
d

,
1
)

. Our proof is based on Serfaty’s modulated-energy method, but compared to that of Han-Kwan and Iacobelli, crucially uses an improved “renormalized commutator” estimate to obtain the larger range for $$\theta $$
θ
. Additionally, we show that for $$\theta \le 1-\frac{2}{d}$$

θ
≤
1
-

2
d

, one cannot, in general, expect convergence in the modulated energy notion of distance.
Optimization of long-range PCR protocol to prepare filaggrin exon 3 libraries for PacBio long-read sequencing
Authors: Mareso Chiara , Albion Elena , Cozza William , Tanzi Benedetta , Cecchin Stefano , Gisondi Paolo , Michelini Sandro , Bellinato Francesco , Michelini Serena , Michelini Silvia , Bertelli Matteo , Marceddu Giuseppe 
Published: January 2023

Abstract
Background
The filaggrin (FLG) protein, encoded by the FLG gene, is an intermediate filament-associated protein that plays a crucial role in the terminal stages of human epidermal differentiation. Loss-of-function mutations in the FLG exon 3 have been associated with skin diseases. The identification of causative mutations is challenging, due to the high sequence homology within its exon 3 (12,753 bp), which includes 10 to 12 filaggrin tandem repeats. With this study we aimed to obtain the whole FLG exon 3 sequence through PacBio technology, once 13-kb amplicons have been generated.

Methods and results
For the preparation of SMRTbell libraries to be sequenced using PacBio technology, we focused on optimizing a 2-step long-range PCR protocol to generate 13-kb amplicons covering the whole FLG exon 3 sequence. The performance of three long-range DNA polymerases was assessed in an attempt to improve the PCR conditions required for the enzymes to function properly. We focused on optimization of the input template DNA concentration and thermocycling parameters to correctly amplify the entire FLG exon 3 sequence, minimizing non-specific amplification.

Conclusions
Taken together, our findings suggested that the PrimeSTAR protocol is suitable for producing the amplicons of the 13-kb FLG whole exon 3 to prepare SMRTbell libraries. We suggest that sequencing the generated amplicons may be useful for identifying LoF variants that are causative of the patients’ disorders.
Nonlinear dynamics of a tubular beam considering distortion of the cross sections and internal resonances
Authors: Casalotti Arnaldo , Zulli Daniele , Luongo Angelo 
Published: January 2023

AbstractThe nonlinear dynamics of a thin tube under the action of a harmonic external load is addressed in the paper. Use is made of a beam-like model which extends the Timoshenko beam model with further kinematic descriptors, related to the change in shape of the cross section. The external load is applied in half cap of the pipe, directly triggering both the bending of the axis-line and the flattening of the cross sections. The equations of motion are projected on a reduced basis constituted by the first three linear modes, and then the solutions are sought via the multiple scale method, for two different external resonance conditions. Internal resonances among the modes are considered as well. The outcomes, compared with pure numerical solutions, highlight the possible energy exchange between local modes, i.e., those describing flattening and warping of the cross sections, and global modes, i.e., those related to bending of the axis-line and rotation of the cross section of the pipe.
Adopting an Ecosystem Approach to Digitalization-driven Organizational Change ? Actionable Knowledge from a Collaborative Project
Authors: Shaba Emanuela , Guerci Marco , Canterino Filomena , Gilardi Silvia , Cagliano Raffaella , Bartezzaghi Emilio 
Published: January 2023

AbstractA vibrant debate has emerged on the opportunities of digitalization for ‘humanizing’ work versus substitution or deskilling effects. Recognizing the processes of designing digitalized organizations as crucial for predicting the outcome of digitalization on workers and labor, extant research has developed an evolutionary ecosystem socio-technical (STS) perspective aimed at designing more human organizations in light of digital transformation. In this study we build upon the STS ecosystem analytical framework by Winby and Mohrman (2018), aiming to explore how the STS design principles, as proposed by said authors, are applied in three big manufacturing companies, in light of digitalization. Data collected through qualitative techniques has been analyzed abductively. Findings provide a detailed overview of how the STS ecosystem design principles are operationalized, and shed novel light on applied design methods, such as ‘agile’ and ‘design thinking’, able to support interconnection among systems, in a never-ending and iterative process. This study extends the existing ecosystem STS organization design conceptual model by exploring ‘how’ we change, ‘who’ the change is for, while also investigating ‘what’ this means for the hitherto conceptualized STS work-system. Implication for management practice and ODC scholarship are also discussed.