bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic parameter estimates indicate the possibility of genetic gain by selecting for reproductive traits of females from a commercial tilapia population (Oreochromis sp.)
Authors: Gonçalves Thaís Gornati , Ataides Kétuly Silva , Carvalheiro Roberto , Nova Fabio Augusto Camisa , Neto Rafael Vilhena Reis 
Published: December 2022

Abstract

This study aimed to verify the possibility of obtaining genetic gain by selecting breeders based on genetic parameter estimates for reproductive performance traits of female tilapia (Oreochromis sp.) from a commercial population. The study was conducted using a database containing information on reproductive traits collected from 2009 to 2021. During the breeding period, the animals were stocked in tanks in a 1:3 male: female ratio. Eggs were collected from the mouth of the females every five days, and the collected eggs were measured in 100 mL beakers to estimate the egg volume. To estimate the variance components and genetic parameters (heritability, correlation, and repeatability), a mixed animal model was used with the fixed effects of the production cycle and breeding tanks, in addition to the additive direct genetic and permanent environmental random effects. The heritability values were 0.26, 0.18, 0.15, and 0.13 for total egg volume, average egg volume, spawning frequency, and average spawning interval, respectively, with repeatability above 0.43 for all analyzed variables, demonstrating the ability of the evaluated breeds to maintain the same production level during the different cycles. The genetic correlations among the variables were high, with a correlation of -0.99 between the total egg volume and the average spawning interval. Thus, selecting for total egg volume, which had the highest heritability, would result in animals that produce a large volume of eggs and have short spawning intervals.
Risk of perinatal deaths for fetuses and early newborns with congenital heart defects
Authors: Zhou Xu , Xie Zhiqun , Kuang Haiyan , Li Ting , Xiao Juan , Chen Chanchan , Zhou Ying , Ye Qian , Xie Donghua , Yang Liu , He Jian , Wang Hua , Fang Junqun 
Published: December 2022

Abstract
Background
There are few studies on perinatal death with congenital heart defects (CHDs). This study analyzed the epidemiological features of CHD and the risk of perinatal death for fetuses and early newborns with CHDs.
Methods
We used data from the Birth Defects Surveillance System of Hunan Province, China, from 2016 to 2020. The surveillance data of perinatal infants (for stillbirth, dead fetus, or live birth between 28 weeks of gestation and seven days after birth) were analyzed. We computed the CHD prevalence and 95% confidence intervals (CI) by Poisson regression and analyzed the epidemiological features of perinatal deaths with CHD.
Results
From 2016 to 2020, a total of 847755 perinatal infants were registered, 14459 cases of birth defects and 4161 cases of CHDs were reported. The CHD prevalence was 4.908‰. Among the 4161 cases of CHDs, 976 cases (23.46%) of perinatal deaths were reported, and 941 cases (96.41%) of perinatal deaths were electively terminated of pregnancy. A relatively high proportion of perinatal deaths occurred in the maternal age group <20 and 20-24 years old. The CHD prevalence was higher in urban areas than in rural areas (6.844‰ vs. 3.598‰) (P<0.05). The most frequent CHD subtypes were ventricular septal defect (VSD), atrial septal defect (ASD), tetralogy of Fallot (TOF), and atrioventricular septal defect (AVSD), which accounted for 56.36%, 12.28%, 3.51% and 2.14% of total CHDs, respectively, and the prevalences were 2.766‰, 0.603‰, 0.172‰, and 0.105‰, respectively. The proportions of perinatal deaths with VSD (9.72%) and ASD (2.74%) were relatively low, while TOF (67.81%) and AVSD (34.83%) were relatively high. Low maternal age, rural residents, low income, low maternal educational background, zero parity, and low gestational age of diagnosis were risk factors for perinatal death.
Conclusion
Our study has revealed the CHD prevalence, major subtypes, and the proportion of perinatal deaths. Furthermore, we have identified risk factors for perinatal death due to CHD. It may be helpful for clinical and public health decisions.
Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy
Authors: Zhang Meng , Ran Siyi , Yin Xueling , Zhang Jiting , Sun Xiao , Sun Wei , Zhu Zhihong 
Published: December 2022

Abstract
Background
Destruction of cellular redox homeostasis to induce cancer cell apoptosis is an emerging tumor therapeutic strategy. To achieve this goal, elevating exogenous oxidative stress or impairing the antioxidant defense system of cancer cells is an effective method. Herein, we firstly report a biocompatible and versatile nanoplatform (MpDA/Vc-Ca/PCM) based on calcium ascorbate (Vc-Ca) loaded mesoporous polydopamine (MpDA) nanoparticles, which simultaneously realized ROS generation, suppression of tumor antioxidant capability, and hyperthermia co-enhanced oncotherapy.
Methods
In this design, Vc-Ca is first loaded into MpDA, and then phase change material (PCM) is wrapped onto the surface of MpDA to form MpDA/Vc-Ca/PCM. The temperature-controlled release of Vc-Ca is characterized. The photothermal performance and GSH consumption capacity of MpDA are evaluated. The cytotoxicity mechanism of Vc-Ca is systematacially investigated. To confirm the synergistic tumor therapeutic effects, in vitro and in vivo biological tests are implemented.
Results
Vc-Ca encapsulated in MpDA by PCM is controllably released due to the melting of PCM matrix in response to photothermal heating upon a near-infrared irradiation. Vc-Ca is proved to be a pro-oxidant that can promote production of ROS (H2O2) in tumor site. Remarkably, MpDA can not only act as a photothermal agent, but also can break the redox balance of cancer cells through depleting the primary antioxidant glutathione (GSH), thus amplifying Vc-Ca-mediated oxidative therapy. Both in vitro and in vivo results demonstrate the significantly enhanced antitumor activity of boosted ROS combined with local hyperthermia.
Conclusion
This study highlights the potential applications of Vc-Ca in cancer treatment, and the prepared multifunctional nanoplatform provides a novel paradigm for high-efficiency oxidation-photothermal therapy.
Escherichia coli BL21(DE3) Optimized Deletion Mutant as the Host for Whole Cell Biotransformation of N‑acetyl‑D‑neuraminic Acid
Authors: Zhang Qiong , Zhang Jiao , Shao Yanhong , Shang Guangdong 
Published: December 2022

Abstract
N‑acetyl‑D‑neuraminic acid (Neu5Ac) is the precursor for antiflu medicine Zanamivir. Chemoenzymatic synthesis of Neu5Ac involves N-acetyl-D-glucosamine 2-epimerase (AGE)-catalyzed epimerization of N-acetyl-D-glucosamine to N-acetyl-D-mannosamine (ManNAc), and aldolase-catalyzed condensation between ManNAc and pyruvate. Herein, via whole cell biotransformation system, BT0453, cloned from Bacteroides thetaiotaomicron, showed the highest biotransformation yield. Next, an optimized host was obtained by deleting the Escherichia coli BL21(DE3) chromosomal genes involved in product exportation, substrate degradation and pH change, a significant 16.5% yield improvement was observed with the host. The research highlights the importance of host’s chromosome engineering for biotransformation.
Survival and prognostic factors in non-small cell lung cancer patients with brain metastases limited access to systemic therapy
Authors: Trikhirhisthit Kyrhatii , Berpan Aniwat , Neesanun Sunee 
Published: December 2022

Abstract
Background
Survival after diagnosis of brain metastases in non-small cell lung cancer (NSCLC) patients was dismal even after local therapy (surgery or brain irradiation), partly because of the systemic burden. Paucities of medical oncologists and molecular testing plus disparities in health care coverage resulted in limited access to systemic chemotherapy, let alone targeted drug or immunotherapy, for brain metastatic non-small cell lung cancer (BM-NSCLC) in Thailand. In this study, we aimed to explore prognostic factors affecting overall survival and evaluate survival outcome in BM-NSCLC limited access to systemic therapy.
Methods
We retrospectively collected 83 BM-NSCLC from a tertiary care hospital in Thailand. Data regarding clinical characteristics and treatment factors including age, sex, performance status, histology, neurologic symptom, extra-cranial metastasis (ECM), receiving whole brain radiotherapy (WBRT) and receiving systemic treatment were collected as independent factors. Associations between these variables and time to death were analyzed using the Cox proportional hazard regression.
Results
The patients' mean age was 63.1 year (SD 8.9). Most of the patients had adenocarcinoma (73%), presented with major neurological symptom (84%), and had brain metastases at their initial diagnosis of lung cancer (65%). Nearly 30% had ECM while 14% received systemic treatment. Three-quarters of patients received WBRT. Less than 15% were tested for actionable mutations. The median survival time was 2.7 months (95%CI: 2.2–4.1 months). One-month, three-month, six-month, and one-year survival probability was 78.3% (95%CI: 52.6–73.2%), 47.0% (95%CI: 36.0-57.2%), 26.5% (95%CI: 17.6–36.3%), and 9.6% (95%CI: 4.5–17.1%), respectively. Multivariable analysis showed that having extra-cranial disease was significantly associated with death (HR 4.22, 95%CI:1.27-14.0,p = 0.019 for first diagnosis lung with any ECM; HR 6.33, 95%CI:1.62–24.79, p = 0.008 for controlled lung & ECM; and HR 11.32, 95%CI:2.89–56.1, p = 0.003 for uncontrolled lung or ECM). Receiving systemic treatment was significantly associated with a reduced risk of death (HR0.39, 95%CI:0.18–0.80, p = 0.011). WBRT was insignificantly associated with prolonged survival (HR 0.79, 95%CI:0.43–1.44, p = 0.441).
Conclusion
Extracranial disease and lack of systemic treatment significantly shortened survival in BM-NSCLC.
Prospective randomised unblinded comparison of sputum viscosity for three methods of saline nebulisation in mechanically ventilated patients: a study protocol
Authors: Arnott Andrew , Hart Robert , McQueen Scott , Watson Malcolm , Sim Malcolm 
Published: December 2022

Abstract
Background

Heat and moisture exchanger (HME) filters are commonly used as passive circuit humidifiers during mechanical ventilation, however, are only ~ 80% efficient. As a result, patients that undergo mechanical ventilation in critical care with HME filter circuits will be exposed to partial airway humidification. This is associated with detrimental effects including increased secretion load which has been shown to be an independent predicter of failed extubation and poor outcome. Nebulised normal saline is commonly utilised to supplement circuit humidification in ventilated patients with high secretion loads, although there are no randomised control trials evaluating its use in critical care. Novel vibrating mesh nebulisers generate a fine aerosol resulting in deeper lung penetration, potentially offering a more effective means of nebulising normal saline in comparison to jet nebulisers. The primary aim of this study is to compare the viscosity of respiratory secretions after treatment with nebulised normal saline administered via vibrating mesh nebuliser or jet nebuliser.

Methods

This randomised controlled trial is enrolling 60 mechanically ventilated adult critical care patients breathing on HME filter circuits with high secretion loads. Recruited patients will be randomised to receive nebulised saline via 3 modalities: 1) Continuous vibrating mesh nebuliser; 2) Intermittent vibrating mesh nebuliser or 3) Intermittent jet nebuliser. Over the 72-hr study period, the patients’ sputum viscosity (measured using a validated qualitative sputum assessment tool) and physiological parameters will be recorded by an unblinded assessor. Total secretion volume and any HME filter changes will also be recorded, in addition to a bedside nurse satisfaction questionnaire. A median reduction in secretion viscosity of ≥ 0.5 on the qualitative sputum assessment score will be deemed as a clinically significant improvement between treatment groups.

Discussion

Nebulised normal saline is commonly utilised for critical care patients with high secretion loads but no randomised control trials exist to guide the technology used or frequency of administration. Novel vibrating mesh technology may also be superior to traditional jet nebulisation for nebuliser delivery. A better understanding of the changes in sputum viscosity after normal saline nebulisation will help improve secretion management during mechanical ventilation.

Trial Registration

https://www.clinicaltrials.gov/ct2/show/NCT05635903
Non-dimensional Wind and Temperature Gradients in the Atmospheric Boundary Layer
Authors: Sakagami Yoshiaki , Acevedo Otávio C. , Maroneze Rafael , Costa Felipe D. , Puhales Franciano S. , Demarco Giuliano 
Published: December 2022

Abstract
We propose a single non-dimensional expression for the wind and temperature vertical profiles in the atmospheric boundary layer (ABL). Two major reformulations are implemented from the generalized function for dimensionless wind and temperature gradients, so that the theory from previous studies may be extended above the surface layer. First, the thermal part of the wind shear is modified based on a surface temperature scale θ* and a thermal-characteristic height zh instead of the Obukhov length. Second, we introduce two new terms in the total Reynolds stress associated with the nonlinear parts of the thermal-mechanical stress, where coefficients α and β maybe describe wind profiles of the low-level jets. The proposed wind and temperature profiles are compared with the universal function in the surface layer and validated with Wangara's wind and temperature profiles up to a height of 2 km, and their measurements of surface turbulent fluxes of heat and momentum. One case of unstable and four cases of stable conditions are selected from the Wangara dataset, representing cases of convective, stratified, nocturnal jet and transition between the stratified and jet profiles. The proposed function has a good correlation in the five cases of temperature and wind profiles with RMSE better than 0.7 K and 0.7 m s-1 respectively. The coefficients zh and b associated with the linear part of Reynolds stress, and the coefficients α and β associated with the nonlinear part of Reynolds stress are analized, and their possible physical meanings are discussed.
Integrated Optical Vortex Microcomb
Authors: Liu Jin , Chen Bo , Zhou Yueguang , Huang Peinian , Ye Chaochao , Cao Qian , Liu Yang , Kim Chanju , Yvind Kresten , Li Jin , Dong Chun-Hua , Fu Songnian , Zhan Qiwen , Wang Xue-Hua , Pu Minhao 
Published: December 2022

Abstract
The explorations of physical degrees of freedom with infinite dimensionalities, such as orbital angular momentum and frequency of light, have profoundly reshaped the landscape of modern optics with representative photonic functional devices including optical vortex emitters1-3 and frequency combs4-6. In nanophotonics, whisper gallery mode microresonators naturally support orbital angular momentum of light7 and have been demonstrated as on-chip emitters of monochromatic optical vortices8. On the other hand, whisper gallery mode microresonators serve as a highly-efficient nonlinear optical platform for producing light at different frequencies - i.e., microcombs9. Here, we interlace the optical vortices and microcombs by demonstrating an optical vortex comb on an III-V integrated nonlinear microresonator. The angular-grating-dressed nonlinear microring simultaneously emits up to 50 orbital angular momentum modes that are each spectrally addressed to the frequency components ((longitudinal whispering gallery modes) of the generated microcomb. We further show that the integrated vortex comb with varied orbital angular momenta distributed across different frequencies exhibits unprecedented advantages in the synthesis of spatio-temporal optical pulses with time-varying orbital angular momenta. This work may immediately boost the development of integrated nonlinear/quantum photonics for exploring fundamental optical physics and advancing photonic quantum technology.
Fluoride levels of Irish Potatoes (Solanum tuberosum L.), Beans (Phaseolus vulgaris L.) and Green Peas (Possum sativa) from Nakuru County, Kenya, and the risk of fluoride overexposure
Authors: Nelima Delphine , Wambu Enos W. , Kituyi John L. 
Published: December 2022

Abstract
Background
Considerable research has been dedicated to investigating fluoride (F) contaminations of water along the Eastern Africa Rift Valley System (EARS) but critical F data on the food systems is still needed for assessing the risk of human F overexposure and for informing the development of plausible strategies for ameliorating its deleterious effects among the communities. The current study investigated F levels of potatoes (Solanum tuberosum L.), beans (Phaseolus vulgaris L.) and garden peas (Possum sativa) from Nakuru County, Kenya, and then assessed the risk of human F overexposure through contaminated foodstuffs.
Results
High F levels exceeding WHO’s recommended dietary allowance of 4 mg/kg has been reported in the three foodstuffs. Fluoride levels in the beans and in the potatoes were high and varied from with regions but F levels in peas were lower and nearly constant across the regions. Risks of F overexposure through F-contaminated foodstuffs increased with increasing body weight and physical activity levels, especially in young children and among male populations.
Conclusions
High F in the foodstuffs have adverse public health implications on the resident communities and the development of plausible remediation and preventive strategies for ameliorating its deleterious effects among the communities is of essence.
Liver Resection vs. TACE for Hepatocellular Carcinoma Modestly Beyond the Milan Criteria: A Multicentre Retrospective Study
Authors: Ma Shouzheng , Zhu Jun , Wang Enxin , Zhao Shoujie , Bai Yang , Zhao Junlong , Li Jing , Zhu Yejing , Bai Tingting , Han Dandan , Xu Fenghua , Chen Hui , Zhang Yongchao , Zhao Yan , Fan Jiahao , Lou Yanju , Yang Man , Chen Xing , Jia Jia , Wu Wenbing , Zhang Chenyu , Tang Yuxin , Qi Xingshun , Chen Dongfeng , Wang Rui , Han Ying , Liu Lei 
Published: December 2022

Abstract
Background: Liver transplantation (LT) is the optimal treatment option for hepatocellular carcinoma (HCC) meeting the Extended Liver Transplant Criteria (ELTC), but it is only offered for the minority. The optimal alternative strategy for HCCs beyond the Milan criteria (BMC) but meeting the ELTC, which is defined as modestly beyond the Milan criteria (MBMC) here, is a matter of concern. The aim of this study was to evaluate the survival benefits of LR compared with transarterial chemoembolization (TACE) for MBMC-HCCs.
Methods: From January 2010 to October 2021, from fifteen Chinese hepatobiliary centres, 1110 MBMC-HCC patients with Child‒Pugh A who underwent LR (n = 424) or TACE (n = 686) were included. Overall survival (OS) benefit of LR versus TACE in the MBMC-HCC cohort was compared based on a propensity score matching (PSM) and was further validated in addition BMC-HCC cohorts selected according to other extended LT criteria (Asan criteria, up-to-7 criteria, French alpha-foetoprotein model and Metroticket 2.0 model).
Results: Survival analyses in the MBMC-HCC cohort as well as other 4 BMC-HCC cohorts demonstrated that OS was significantly longer in the LR group than that in the TACE group (all log-rank P < 0.001). After a 1:1 PSM in the MBMC-HCC cohort, multivariate analysis and subsequent subgroup analyses based on tumour burden and other important covariates further confirmed the robust survival advantage of LR compared to TACE.
Conclusions: LR rather than TACE is highly recommended as the preferred alternative for potential LT candidates with MBMC-HCC regardless of tumor burden.
A mathematical prediction model of the grinding force in ultrasonic assisted grinding of ZrO2 ceramics with experimental validation
Authors: Liu Sheng , Ding Kai , Su Honghua , Zhuang Bailiang , Li Qilin , Lei Weining , Zhou Zongchen , Han Xiao 
Published: December 2022

Abstract

Zirconia is gradually used in manufacturing aerospace and other fields because of its excellent mechanical processing properties. Due to its hardness and brittleness, zirconia can easily cause excessive and unstable changes in grinding force during machining, resulting in extensive surface damage and poor surface quality. Therefore, it is important to establish an appropriate grinding force model and achieve accurate control and prediction of the grinding force. Ultrasonic-assisted grinding can reduce grinding forces, improve workpiece surface quality，and increase processing efficiency. However, the grinding force model for ultrasonic-assisted grinding is still not adequately investigated. In this study, a new method for predicting the axial force of ultrasonic-assisted grinding is proposed. Vickers hardness and indentation fracture theories combine two different methods: plastic removal and brittle fracture. Moreover, conventional and ultrasonic-assisted grinding tests are performed. Then, the relationship between grinding forces and process parameters is investigated using numerical statistical calculation methods. The grinding force data obtained from the test validate the theoretical model, with the average error between the theoretical and experimental values being 22.87%. The influence of machining variables on the grinding force is investigated, and experimental results of conventional al grinding and ultrasonic-assisted grinding are compared. It is found that the rotary ultrasonic-assisted grinding force can be reduced by up to 66.76%.
Using smart ecosystems against pandemics
Authors: Péntek István , Adamkó Attila 
Published: December 2022

Abstract
In the recent decade, increasingly many technological innovations have been incorporated into smart city architectures. The modern lifestyle requires people to have at least one fitness tracker or another wearable device in most households. Usually, devices are equipped with more biosensors thus producing valuable time series that can be used to track the desired areas. The use of bio-sensory time series is not limited to private purposes only, data can be used to improve services in everyday life. The data generated by bio-sensory devices primarily infiltrate smart home solutions. However, the extended smart home solutions give the opportunity to improve smart city solutions as well. The consecutive change in the subject technologies that form the smart city and smart home architectures, as well as the sensitivity of data from confidential sources, is the key factor. The vendors must keep up with the continuous change. This research will demonstrate results that can make the services of smart ecosystems more valuable by using bio-sensory data. Based on the presented research results, smart ecosystems can act much more effectively against an epidemic or a pandemic. The research paper focuses on how bio-sensory time series data can be collected and used, how the data can be integrated into smart ecosystems, and how it can be integrated into smart healthcare solutions.
Hankel-type operator acting on Hardy spaces and weighted Bergman spaces
Authors: Zhou Zhihui 
Published: December 2022

Abstract

Inspired by Xiao’s work about the Hankel measures for the weighted Bergman spaces, in this paper, if β > 0 and the measure μ is a complex Borel measure on the unit disk D, we define the Hankel type operator Kμ,β by
Kμ,β : ƒ →∫D(1 − wz)−(β)ƒ(w)dμ(w).
The operator itself has been widely studied when μ is a positive Borel measure supported on the interval [0, 1). We study the boundedness of Kμ,1 acting on Hardy spaces and the boundedness of Kμ,α, α > 1 acting on weighted Bergman spaces. Then we mainly raise and answer some questions about the boundedness of those operators. Also, we find some special measures μ′s such that s-Hankel measure is equal to s-Carleson measure.