bluuebunny/crossref_metadata_2025_split huggingface dataset:
GMOCSO: Multi-objective Cat Swarm Optimization Algorithm based on a Grid System
Authors: Ahmed Aram M. , Rashid Tarik A. , Saeed Soran Ab. M. , Noori Kaniaw A. , Hassan Bryar A. , Rahman Chnoor M , Ahmed Omed H. , Umar Shahla U. , Yaseen Zaher Mundher 
Published: May 2023

Abstract
This paper presents a multi-objective version of the Cat Swarm Optimization Algorithm called the Grid-based Multi-objective Cat Swarm Optimization Algorithm (GMOCSO). Convergence and diversity preservation are the two main goals pursued by modern multi-objective algorithms to yield robust results. To achieve these goals, we first replace the roulette wheel method of the original CSO algorithm with a greedy method. Then, two key concepts from Pareto Archived Evolution Strategy Algorithm (PAES) are adopted: the grid system and double archive strategy. Several test functions and a real-world scenario called the Pressure vessel design problem are used to evaluate the proposed algorithm's performance. In the experiment, the proposed algorithm is compared with other well-known algorithms using different metrics such as Reversed Generational Distance, Spacing metric, and Spread metric. The optimization results show the robustness of the proposed algorithm, and the results are further confirmed using statistical methods and graphs. Finally, conclusions and future directions were presented..
Where the toad crosses the road: Multi-method Texas herpetofauna roadkill modeling for conservation planning
Authors: Chyn Kristina , Tracy James L. , Wright Wendy , Fitzgerald Lee A. , Coulson Robert 
Published: May 2023

Abstract

Road mortality is a significant contributor to the global decline in herpetofauna, making regional roadkill models important for conservation planning. We used the iNaturalistRoadkills of Texascommunity science volunteered geographic information database to develop the first regional herpetofauna roadkill models in North America for: (1) all Texas herpetofauna combined; (2) Texas Horned Lizards (Phrynosoma cornutum), a Texas state threatened species; and (3) Gulf Coast Toads (Incilius nebulifer), a common generalist species. We novelly compare the utility of extrapolative feature-selected MaxEnt models to interpolative kernel density estimate models (KDEMs) of roadkill to inform conservation planning for sensitive Texas herpetofauna. A random subset feature selection algorithm was used to identify subsets of five to seven of 55 variables optimizing Maxent roadkill model performance and for ranking variables. MaxEnt roadkill models had acceptable to excellent accuracy, outperforming KDEMs for Texas herpetofauna combined and the Texas Horned Lizard. Both model types had poor accuracy in projecting Gulf Coast Toads roadkill, however, KDEMs had much lower complexity. Roadkill models of both types for various taxa revealed roadkill risk areas for partially sympatric sensitive species having insufficient data for individual models, including the Texas Tortoise (Gopherus berlandieri) and Houston Toad(Anaxyrus houstonensis). Top ranked variables in feature-selected MaxEnt roadkill models included distance to residential roads, human population density, percent cover developed open space, and spatial density of non-roadkill herpetofauna occurrences. Identified high roadkill risk areas should be further surveyed to refine roadkill projections and inform mitigation planning to support sensitive Texas herpetofauna conservation efforts.
Production,characterization and applications of cellulase from thermophilic Anoxybacillus and Bacillus
Authors: Sharif Sobia , Shah Asad Hussain , Fariq Anila , Jannat Sammyia , Rasheed Sajida Rasheed 
Published: May 2023

Abstract
Organic biomass is rich in cellulose and it is the most abundant substrate for biofuel production. To address the challenges posed by cellulosic biomass, cellulolytic microorganisms help improve the feasibility of biofuel production from cellulosic biomass. Present research was aimed to assess the cellulase production and activity of thermophilic isolates discovered from Tata Pani hot spring, Kotli AJ&K. Four thermophilic bacteria were screened for thermostable cellulase production on the basis of clear zone formation with 1 % CMC. Selected strains were Anoxybacillus mongoliensis (MBT001), Anoxybacillus flavithermus (MBT002), Bacillus spp. (MB004) and MBT003 (Anoxybacillus mongoliensis and Anoxybacillus flavithermus). Enzyme production and activity was assayed by DNS method. Optimum catalyst formation was observed and validated by RSM at 70 °C, 7 pH and 1.25 % substrate concentration with inocula size of 300 µL after 48 hrs of incubation. All the isolates gave maximum activity in presence of CMC upto range of 4.1-4.9 U/mL. Optimum enzyme activity of crude and purified enzyme was obtained upto range of 3-4 U/mL at pH 7. Crude and purified enzyme was stable upto 70 °C of temperature. Stability of cellulase from selected isolates was varied with surfactants and commercially available detergents being more stable with tween 20 and with commercially available Surf Excel. Cellulase from all isolates exhibited enzymatic hydrolysis of pre-treated banana peels. Crude cellulase from some isolates showed antimicrobial activity against Enterobacter and Pseudomonas. This study has showed that thermophilic bacteria are potential source of thermostable cellulase which can be highly used for many biotechnological purposes.
Quantitative metabarcoding of soil fungi and bacteria
Authors: Camacho-Sanchez Miguel 
Published: May 2023

Abstract

Metabarcoding is a powerful tool to characterize biodiversity in biological samples. The interpretation of taxonomic profiles from metabarcoding data has been hindered by their compositional nature. Several strategies have been proposed to transform compositional data into quantitative, with their intrinsic limitations. Here, I propose a workflow based on bacterial and fungal cellular internal standards (spike-ins) for absolute quantification of the microbiota in soil samples. These standards were added to the samples before DNA extraction in amounts estimated after qPCRs, to target around 1-2% coverage in the sequencing run. In bacteria, proportions of spike-in reads in the sequencing run were very similar (< 2-fold change) to those predicted by the qPCR assessment, but for fungi they differed up to 40-fold. The little variation between replicated samples highlights the reproducibility of the method. Estimates based on multiple bacterial spike-ins were highly correlated (r = 0.99). Procrustes analysis evidenced significant biological effects on the community composition when normalizing compositional data. A protocol based on qPCR estimation of input amounts of cellular spikes is proposed as a cheap and reliable strategy for quantitative metabarcoding of biological samples.
Large Eddy Simulations for the Ahmed Car at 25° Slant Angle at Different Reynolds Numbers
Authors: Menter Florian R. , Hüppe Andreas , Flad David , Garbaruk Andrey V. , Matyushenko Alexey A. , Stabnikov Andrey S. 
Published: May 2023

Abstract
The article investigates the feasibility of Large Eddy Simulation methods to accurately compute the flow around the Ahmed car body at 25° slant angle. The flow is computed at two different Reynolds numbers and with different turbulence modeling concepts using a large variety of grids. Issues associated with the accurate computation of the separation at the slant onset will be discussed in detail.
The effects of the “deadly trio” (warming, acidification, and deoxygenation) on fish early ontogeny
Authors: Pimentel Marta S. , Santos Catarina P. , Pegado Maria R. , Sampaio Eduardo , Pousão-Ferreira Pedro , Lopes Vanessa M. , Moura Omar , Santos David , Rosa Rui 
Published: May 2023

Abstract

The interaction between increased dissolved carbon dioxide, rising temperatures, and oxygen loss – the so-called “deadly trio” – is expected to strongly affect marine biota over the coming years, potentially undermining ocean services and uses. Nonetheless, no study has so far scrutinized the cumulative impact of these three stressors on fish embryonic and larval stages, known to be particularly vulnerable to environmental stress. To fill this knowledge gap, we implemented a fully multi-factorial design to investigate the effects of acute warming (Δ + 4°C; 22 ºC), acidification (Δ − 0.4 pH units; ~ 7.7 pCO2) and deoxygenation (Δ − 60% O2 saturation, ~ 3 mg O2 l− 1) over a comprehensive array of physiological (hatching success, survival rates, deformities rates, and heart rates) and behavioural responses (larvae responsiveness and phototaxis) across the early ontogeny of the temperate gilthead seabream (Sparus aurata). Deoxygenation was the main driver of negative impacts in the hatching success (64.25%), survival (46.71%), and heart rates (31.99%) of recently hatched larvae, being generally further exacerbated when warming and acidification co-occurred. On the other hand, acidification was the only factor to induce a significant decrease in the proportion of phototactic behaviour (50%). The behavioural and physiological responses showed to be highly correlated across experimental treatments, specifically, phototaxis was negatively correlated with the incidence of malformations, and positively correlated with heart rates. Overall, our findings indicate that the interaction between warming, acidification, and deoxygenation is markedly detrimental to fish early developmental stages, impacting several key features at this critical life stage that may eventually cause adverse carry-over effects. Importantly, our analysis highlights the need to assess the concurrent impacts of stressors’ interaction on marine taxa to better predict future ecosystem responses to ocean changes.
A FACE VITIMADA: MORBIDADE ENTRE MULHERES ATENDIDAS EM SERVIÇOS SENTINELAS NO BRASIL
Authors: De Azevedo Machado Flávia Christiane , Serejo da Costa Anna Paula , Fernandes Ferreira Maria Ângela 
Published: May 2023

Introdução: Ao longo da história, muitos homens utilizam-se da violência contra suas parceiras como forma de afirmação da sua identidade e domínio viril. Em muitas situações, as agressões são direcionadas à face que justamente representa o centro da atenção do ser humano. Objetivo: O presente artigo tem como objetivo analisar os atendimentos de emergência em mulheres vítimas de violência na região de cabeça e pescoço. Metodologia: Foram analisados dados do inquérito de Vigilância e Acidentes em 25 capitais e no Distrito Federal no ano de 2011. Analisaram-se 351 atendimentos de mulheres adultas entre 15 e 49 anos em relação à ocorrência de violência na região de cabeça e pescoço, o que corresponde a 40,6% das mulheres vítimas de violência. Resultados: A ocorrência da violência foi predominante em mulheres jovens, negras e com pouca escolaridade. As violências foram mais frequentes no domicílio (45,5%) e a referência à intencionalidade do ato de violência pelo agressor predominou entre as vítimas de violência. Em todos os casos, as vítimas de agressão na região de cabeça e pescoço sofreram violência física, sendo o agressor do sexo masculino (77,4%) e identificado como parceiro ou ex-parceiro íntimo em 44,5%. Conclusões: É cada vez mais importante que o serviço esteja preparado para receber essas mulheres vítimas de violência, mediante conformação de Redes de Atenção e efetivação da instersetorialidade. Isto pressupõe, inclusive, a maior inserção do cirurgião-dentista na identificação e acolhimento dessas vítimas para posteriores encaminhamentos.
Palavras-Chave: Violência doméstica, face, morbidade, feminino.
Phytochemicals as Substances that Affect Astrogliosis and their Implications for the Management of Neurodegenerative Diseases
Authors: Forouzanfar Fatemeh , Pourbagher-Shahri Ali Mohammad , Vafaee Farzaneh , Sathyapalan Thozhukat , Sahebkar Amirhossein 
Published: May 2023

:
Astrocytes are a multifunctional subset of glial cells that are important in maintaining
the health and function of the central nervous system (CNS). Reactive astrocytes
may release inflammatory mediators, chemokines, and cytokines, as well as neurotrophic
factors. There may be neuroprotective (e.g., cytokines, like IL-6 and TGF-b) and neurotoxic
effects (e.g., IL-1β and TNF-a) associated with these molecules. In response to
CNS pathologies, astrocytes go to a state called astrogliosis which produces diverse and
heterogenic functions specific to the pathology. Astrogliosis has been linked to the progression
of many neurodegenerative disorders. Phytochemicals are a large group of compounds
derived from natural herbs with health benefits. This review will summarize how
several phytochemicals affect neurodegenerative diseases (e.g., Alzheimer’s disease,
Huntington’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease) in basic
medical and clinical studies and how they might affect astrogliosis in the process.
Integrated Network Pharmacology and Metabolomics to Dissect the
Mechanisms of Naringin for Treating Cervical Cancer
Authors: Yin Ziwei , Hua Xuefeng , Lu Minqiang 
Published: May 2023

Introduction:
Cervical cancer is one of the malignant cancers with high mortality
among women worldwide. Although vaccines and early detection have reduced cervical cancer
mortality, it remains a malignancy with a high mortality rate in women.

Objective:
We aimed to develop a novel integrated strategy that combines metabolomics with
network pharmacology to explore the therapeutic mechanisms of naringin in cervical cancer. The
mechanism of naringin intervention in cervical cancer was initially clarified by metabolomics and
network pharmacology.

Methods:
The method of LC-MS and network pharmacology for the detection and identification of
potential biomarkers and the mechanisms of action of naringin was used. The metabolites were detected
and identified based on ultra-high-performance liquid chromatography coupled with Quadrupole-
Exactive Orbitrap MS (UHPLC-Q-Exactive Orbitrap MS) and followed by the network
pharmacology analysis.

Results:
In network pharmacology, naringin played a synergetic role through regulatory shared
pathways, such as steroid hormone biosynthesis, sphingolipid signaling pathway and arachidonic
acid metabolism, etc. Besides, the metabolomics analysis showed that 20 differential metabolites
and 10 metabolic pathways were mainly involved in the therapeutic effect of naringin on cervical
cancer. The result showed that naringin treatment for cervical cancer mainly occurs through the
following metabolic pathways: amino acid metabolism and arachidonic acid metabolism.

Conclusion:
This work provided valuable information and a scientific basis for further studies of
naringin in the treatment of cervical cancer.
Design, Synthesis and Molecular Docking Studies of Pyrazoline Derivatives
as PI3K Inhibitors
Authors: Kumar Rohit , Kumar Arvind , Kumar Adarsh , Singh Ankit Kumar , Kumar Pradeep 
Published: May 2023

Aim:
Design, synthesis and molecular docking studies of quinoline/naphthalene containing
pyrazoline derivatives as PI3K inhibitors.

Background:
Phosphatidylinositol 3-kinases (PI3Ks) belong to the family of enzymes, which are
associated with various cellular functions such as cell growth, proliferation, differentiation etc.
Overexpression or any changes in these functions may result in various abnormalities, which in
turn cause cancer.

Objectives:
To perform synthesis and molecular docking studies of quinoline/naphthalene containing
pyrazoline derivatives as PI3K inhibitors.

Methods:
2-Chloroquinoline-3-carbaldehyde was synthesized by a reaction of acetanilide and
POCl3. The latter was reacted with substituted acetophenones to synthesize chalcones, which were
reacted with substituted phenyl hydrazines to yield pyrazoline derivatives (Series I). Similarly, pchloro
benzaldehyde was reacted with 2-acetonapthone to yield chalcone with substituted phenyl
hydrazines to yield pyrazoline derivatives (Series II).

Results:
The synthetic compounds were subjected to molecular modelling experiments using Schrodinger
2016 software and evaluated in silico for their PI3K binding affinities. All the compounds had better docking
scores than AMG-319 (-4.36 Kcal/mol) and comparable docking scores with PI-103 (-6.83 Kcal/mol).

Conclusion:
Compounds 5 and 3 had the best docking scores (-7.85 and -7.17 Kcal/mol, respectively). The
synthesized compounds have better docking scores than the reference drug AMG-319. As a result, they
might be used as lead molecules in investigating PI3K inhibitors.
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis
Authors: dos Santos Michelli , de Faria Mariana Teixeira , da Silva Jonatas Oliveira , Gandra Isadora Braga , Ribeiro Anna Julia , Silva Kamila Alves , Nogueira Lais Moreira , Machado Juliana Martins , da Silveira Mariano Reysla Maria , Gonçalves Ana Alice Maia , Ludolf Fernanda , Candia-Puma Mayron Antonio , Chávez-Fumagalli Miguel Angel , Campos-da-Paz Mariana , Giunchetti Rodolfo Cordeiro , Galdino Alexsandro Sobreira 
Published: May 2023

Background:
schistosomiasis is a neglected tropical parasitic disease caused by trematode worms of the genus schistosoma, which affects approximately 240 million people worldwide. the diagnosis of the disease can be performed by parasitological, molecular, and/or immunological methods, however, the development of new diagnostic methods still essential to guide policy decisions, monitor disease trends and assess the effectiveness of interventions.

Objective:
in this sense, the current work summarizes the findings of a systematic review regarding antigens applied in the enzyme-linked immunosorbent assay test, which were patented and published over the last ten years.

Methods:
the literature search strategy used medical subject heading (mesh) terms to define as descriptors. “schistosoma mansoni” was used in arrangement with the descriptors “immunoassay”, “enzyme-linked immunosorbent assay”, “elisa”, and “antigens”, using the “and” connector. the patent search was done using keywords, including diagnosis and schistosoma or schistosomiasis or schistosome. several databases were employed for the patent search, such as intellectual property national institute; european patent office; the united states patent and trademark office; patent scope, and google patents.

Results:
forty-one articles were retrieved, of which only five met the eligibility criteria. seventeen patents were taken from the databases, and a brief description of the most relevant inventions is given here.

Conclusion:
schistosomiasis is considered the most important helminthic disease in worldwide. therefore, it is important to of searching for and develops diagnostic methods based on serology to reduce morbidity and mortality caused by the disease.
Recent Advances in the Development of Membrane-derived Vesicles for
Cancer Immunotherapy
Authors: Xiao Yuai , Wu Minliang , Xue Chunyu , Wang Yuchong 
Published: May 2023

Abstract:
The surface proteins on cell membranes enable the cells to have different properties, such as
high biocompatibility, surface modifiability, and homologous targeting ability. Cell-membrane-derived
vesicles have features identical to those of their parental cells, which makes them one of the most promising
materials for drug delivery. Recently, as a result of the impressive effects of immunotherapy in
cancer treatment, an increasing number of researchers have used cell-membrane-derived vesicles to
enhance immune responses. To be more specific, the membrane vesicles derived from immune cells,
tumor cells, bacteria, or engineered cells have the antigen presentation capacity and can trigger strong
anti-tumor effects of the immune system. In this review, we first indicated a brief description of the
vesicles and then introduced the detection technology and drug-loading methods for them. Secondly, we
concluded the characteristics and applications of vesicles derived from different sources in cancer immunotherapy.
Traditional and Innovative Anti-seizure Medications Targeting Key Physiopathological
Mechanisms: Focus on Neurodevelopment and Neurodegeneration
Authors: Sciaccaluga Miriam , Ruffolo Gabriele , Palma Eleonora , Costa Cinzia 
Published: May 2023

Abstract:
Despite the wide range of compounds currently available to treat epilepsy, there is still no
drug that directly tackles the physiopathological mechanisms underlying its development. Indeed, antiseizure
medications attempt to prevent seizures but are inefficacious in counteracting or rescuing the
physiopathological phenomena that underlie their onset and recurrence, and hence do not cure epilepsy.
Classically, the altered excitation/inhibition balance is postulated as the mechanism underlying epileptogenesis
and seizure generation. This oversimplification, however, does not account for deficits in
homeostatic plasticity resulting from either insufficient or excessive compensatory mechanisms in response
to a change in network activity. In this respect, both neurodevelopmental epilepsies and those
associated with neurodegeneration may share common underlying mechanisms that still need to be fully
elucidated. The understanding of these molecular mechanisms shed light on the identification of new
classes of drugs able not only to suppress seizures, but also to present potential antiepileptogenic effects
or “disease-modifying” properties.
Prakiraan Kebutuhan Energi Listrik Dengan Jaringan Saraf Tiruan (Artificial Neural Network) Metode Backpropagation Tahun 2020-2025
Authors: Setyowati Diah , Sunardiyo Said 
Published: May 2023

Kebutuhan energi listrik merupakan salah satu hal utama yang diprioritaskan oleh penyedia listrik. Perlunya dilalukan perencanaan terhadap pemenuhan kebutuhan energi listrik oleh penyedia listrik setiap tahunnya. Penelitian dilakukan untuk memprediksi kebutuhan energi listrik PT PLN (Persero) UP3 Semarang tahun 2020-2025 dengan mengembangkan suatu model Jaringan Saraf Tiruan metode Backpropagation menggunakan software Matlab. Beberapa variabel yang digunakan yaitu jumlah penduduk, jumlah pelanggan, PDRB, daya tersambung, beban puncak dan total produksi energi listrik. Variabel tersebut merupakan beberapa faktor yang mempengaruhi peningkatanÂ kebutuhan energi listrik. Hasil penelitian menghasilkan Mean Absolute Percentage Error (MAPE) sebesar 0,4% dan Growth of Total % (GOT %) sebesar 2,7% setiap tahunnya.