bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interobserver variability in interim PET assessment in Hodgkin lymphoma—reasons and solutions
Authors: Georgi Thomas W. , Kurch Lars , Hasenclever Dirk , Warbey Victoria S. , Pike Lucy , Radford John , Sabri Osama , Kluge Regine , Barrington Sally F. 
Published: March 2023

Introduction
Interim PET (iPET) assessment is important for response adaptation in Hodgkin lymphoma (HL). The current standard for iPET assessment is the Deauville score (DS). The aim of our study was to evaluate the causes of interobserver variability in assigning the DS for iPET in HL patients and to make suggestions for improvement.

Methods
All evaluable iPET scans from the RAPID study were re-read by two nuclear physicians, blinded to the results and patient outcomes in the RAPID trial. The iPET scans were assessed visually according to the DS and, thereafter, quantified using the qPET method. All discrepancies of more than one DS level were re-evaluated by both readers to find the reason for the discordant result.

Results
In 249/441 iPET scans (56%) a concordant visual DS result was achieved. A “minor discrepancy” of one DS level occurred in 144 scans (33%) and a “major discrepancy” of more than one DS level in 48 scans (11%). The main causes for major discrepancies were 1) different interpretation of PET-positive lymph nodes—malignant vs. inflammatory; 2) lesions missed by one reader and 3) different assessment of lesions in activated brown fat tissue. In 51% of the minor discrepancy scans with residual lymphoma uptake, additional quantification resulted in a concordant quantitative DS result.

Conclusion
Discordant visual DS assessment occurred in 44% of all iPET scans. The main reason for major discrepancies was the different interpretation of PET positive lymph nodes as malignant or inflammatory. Disagreements in evaluation of the hottest residual lymphoma lesion can be solved by the use of semi-quantitative assessment.
O CUIDADO AO IDOSO DURANTE A PANDEMIA DA COVID-19: REVISÃO INTEGRATIVA
Authors: Souza Juliana Rosa de , Sandri Juliana Vieira de Araujo , Alves Marta Machado 
Published: March 2023

Resumo: Objetivo: analisar o cuidado ao idoso frente a pandemia da COVID-19 (Coronavirus Disease 2019), no contexto da família e da enfermagem. Método: estudo de revisão integrativa, sobre artigos indexados na Biblioteca Virtual de Saúde; Scientific Electronic Library Online e Google Scholar, em português, publicados entre março a outubro 2020. A estratégia de busca foi organizada conforme a especificidade de cada base de dados usando os operadores boleanos e os descritores: idoso, família, coronavírus, pessoas confinadas no lar, prevenção, enfermagem. Resultados: identificados 120 artigos na Biblioteca Virtual de Saúde; 110 Google Scholar e 35 Scientific Electronic Library Online. Após seleção resultou em 35 artigos, que posteriormente, foram reavaliados, totalizando quatro artigos, destes 50,0% na Scientific Electronic Library Online e 50,0% na Biblioteca Virtual de Saúde; 1 artigo por revista, 25,0%; localização territorial do periódico foi a região sul (50,0%); categoria profissional dos autores foi de enfermeiros 49,9% e; 100,0% utilizou a abordagem qualitativa. A síntese do conhecimento está apresentada em dois temas: o cuidado familiar junto aos idosos frente à pandemia da COVID-19 e; assistência de enfermagem ao idoso na pandemia da Covid-19. Conclusão: evidenciou-se a fragilidade da pessoa idosa frente à COVID-19 e fez emergir a necessidade de novos olhares sobre o cuidado familiar e de enfermagem ao idoso diante do isolamento social.
REDES DE PROTEÇÃO, ARTICULAÇÃO E CUIDADOS PARA PESSOAS EM SITUAÇÃO DE SOFRIMENTO E DESEJO SUICIDA NO SUL DO BRASIL
Authors: Marinho Benfica Vanessa Brenerk 
Published: March 2023

Resumo: O fenômeno suicídio cercado por tabus, estigma, preconceito e discurso raso, vem nos últimos tempos sendo pauta de discussão e preocupação no âmbito da saúde pública num alcance global. Embora haja políticas públicas voltada a prevenção contra o suicídio, campanhas, tabus descontruídos e preconceitos sendo discutidos, o suicídio tem se tornado ponto de muita preocupação pois, índices entre jovens com idade de 15 a 35 anos, vem aumentado consideravelmente em diversos países. O tema suicídio é complexo e diversificado, devendo ser compreendido por um prisma que compõe muitas faces e elementos que vão além de configurações como, transtornos psiquiátricos, traumas, conflitos, falências ou decepções. Pensando na emergente situação do aumento de casos de suicídio no país, esse trabalho buscou refletir a importância das políticas públicas e redes de proteção voltadas ao tema em questão, deste modo, mapeou-se a região da Associação dos Municípios da Foz do Rio Itajaí - AMFRI (composta por onze municípios no Sul do Brasil), Redes de Proteção locais nos quais a população dessa região tem acesso a informações e auxilio para si ou terceiros que se encontram em pensamento suicida. O objetivo desse trabalho foi fazer um levantamento dos locais e criar um blog como ferramenta tecnológica na qual disponibiliza as informações necessárias e os locais de Redes de Proteção, Articulação e Cuidados oferecidos. O Sistema Único de Saúde – SUS configura as redes de proteção, auxilio e enfrentamento ao suicídio, sendo no Brasil o mais amplo e indispensável acesso da população. Essa é uma pesquisa qualitativa e quantitativa com análise de dados bibliográficos em Base de Dados e documentos específicos que compõe as legislações vigentes da saúde como Ministério da Saúde do Brasil e Organização Mundial da Saúde – OMS. Palavras-chave: Suicídio. Redes de Proteção. Acolhimento e Enfretamento. SUS.
Effect of Multipass Friction Stir Processing on Structure and Mechanical Properties of CuAl9Mn2 Copper Alloy
Authors: Cheremnov A.M. , Chumaevskii A.V. , Knyazhev E.O. , Kalashnikova T.A. , Kolubaev E.A. 
Published: March 2023

This study examines the structure and mechanical properties of CuAl9Mn2 copper alloy processed via friction stir processing. Workpieces, 2 mm thick, were processed using four tool passes. After the initial FSP pass, the stir zone structure was found to be non-homogeneous, with grains changing from equiaxed to elongated in the material flow direction. Grain sizes decreased from 80-140 µm to 3-8 µm. However, after the fourth pass, the stir zone became more homogeneous with equiaxed grains and sizes ranging from 2-6 µm.
The increase in microhardness and tensile properties of the material is attributed to the processing temperature, mechanical mixing, and grain refinement. The ultimate tensile strength of the FSP material increased by 13% relative to the metal prior to processing, whether one or four passes were used. Additionally, microhardness in the stir zone increased, which is consistent with the results of mechanical tensile tests.
Estudos com egressos da pós-graduação em educação: Mapeamento das teses brasileiras 2013-2021
Authors: Mesquita Aline Luz , Fortunato Ivan 
Published: March 2023

Este artigo mapea sistemáticamente as teses brasileiras focadas na temática dos egressos da Pós-Graduação em Educação entre os anos de 2013 e 2021. Trata-se de uma pesquisa de cunho quantitativo e qualitativo realizada utilizando o Catálogo de Teses e Dissertações da CAPES com a seleção dos trabalhos que abordaram a temática de egressos da pós graduação e que adotaram pós graduados no percurso metodológico definido, ou seja, como sujeitos de pesquisa. Após a seleção das teses foi desenvolvida uma sistematização técnica seguida de uma análise qualitativa mais aprofundada, que buscou destacar o objetivo geral, metodologia, sujeitos envolvidos, coleta de dados, referenciais teóricos e principais resultados das pesquisas. Os resultados apontam o potencial de estudos desenvolvidos com egressos de Pós-graduação para os cursos envolvidos e âmbito educacional no geral, pois com esse levantamento sistemático identificamos modificações na trajetória de egressos propiciadas pelo percurso formativo trilhado. O estudo evidencia, assim, o potencial formativo na pós-graduação sob a perspectiva dos egressos, bem como a importância de estudos envolvendo egressos para aprofundar saberes acerca de políticas e práticas em tal segmento educativo. Espera-se trazer maior visibilidade para estudos com egressos como fonte de informações, visando o aprimoramento da formatação adotada nos cursos de Pós-graduação para um desenvolvimento profissional significativo.
Structural, physical, and radiation absorption properties of a significant nuclear power plant component: A comparison between REX-734 and 316L SS austenitic stainless steels
Authors: Say Yakup , Güler Ömer , Kavaz Esra , ALMisned Ghada , Ene Antoaneta , Tekin Huseyin Ozan 
Published: March 2023

Abstract
Austenitic stainless steels (SSs) are commonly used as in-core and surrounding structural materials in today’s industrial BWR and PWR systems. Such adaptable steels have also been the primary materials studied and used in several advanced nuclear reactor technologies, such as fast breeding and magnetic fusion reactors. In this study, some critical material properties, such as structural, physical, and radiation-shielding properties of REX-734 and 316L SS, were experimentally evaluated and compared to those of a number of other alloys. In addition to homogeneous element distribution, both alloys exhibit strong crystal orientation. The REX-734 alloy has a tensile strength of 1,259 MPa, whereas the 316L SS alloy has a tensile strength of 495 MPa. Moreover, nitrogen in the REX-734 alloy formed ultra-hard nitrides with Cr, Nb, and Si and precipitated into the structure and increased the strength. According to our findings, the mass attenuation coefficient values of the 316L SS sample were slightly higher than those of the REX-734 sample at all energies. It can be concluded that the REX-734 sample, with its exceptional strength qualities and excellent radiation attenuation capabilities, may be a viable nuclear power plant material for future investigations.
Optimal convergence factors for general Fourier coefficients
Authors: Gogoladze Larry , Cagareishvili Giorgi 
Published: March 2023

Abstract
Stefan Banach proved that even the Fourier series of the function

f
⁢

(
x
)

=
1

{f(x)=1}

(

x
∈

[
0
,
1
]

)

{(x\in[0,1])}

might not be convergent for some orthonormal systems (ONS). Thus we can conclude that the Fourier series of functions belonging to a certain differential class cannot be convergent in general. On the other hand, for classical ONS (trigonometric, Haar, Walsh systems, …), the convergence of Fourier series of differentiable class functions is a simple subject. In this paper, we investigate the sequence of positive numbers such that, multiplying the Fourier coefficients of Lipschitz class functions by these numbers, one obtains a convergent series of the special form. From the convergence of these special form series, we derive the convergence of the special Fourier series of Lipschitz class functions with respect to general ONS. The obtained results are best possible.
Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU
Authors: Kieffer Hannah , Carlton Katherine , Adams Samuel , Jozwik Jenna , Cabacungan Erwin , Cohen Susan S. 
Published: March 2023

Abstract

Objectives
Therapeutic hypothermia (TH) is now standard of care for the neuroprotection of patients with moderate to severe hypoxic-ischemic encephalopathy (HIE). TH misuse results in increased medical complication rates and high health care resource utilization. Quality improvement (QI) methodology can address drift from clinical guidelines. Assessment of sustainability of any intervention over time is an integral part of the QI methodology.

Methods
Our prior QI intervention improved medical documentation using an electronic medical record-smart phrase (EMR-SP) and demonstrated special cause variation. This study serves as Epoch 3 and investigates the sustainability of our QI methods to decrease TH misuse.

Results
A total of 64 patients met the diagnostic criteria for HIE. Over the study period, 50 patients were treated with TH, and 33 cases (66%) used TH appropriately. The number of appropriate TH cases between cases of misuse increased to an average of 9 in Epoch 3 from 1.9 in Epoch 2. Of the 50 cases, 34 (68%) had EMR-SP documentation included. Length of stay and TH complication rates did not vary between cases of TH misuse and appropriate TH use.

Conclusions
Our study confirmed a sustained decrease in TH misuse, despite inconsistent use of EMR-SP. We speculate that culture change involving increased awareness of guidelines through education may have contributed more to a lasting change.
The crystal structure of di-μ-1-naphthylacetato-κ
3
O,O′:O;κ
3
O:O,O′-bis[(1-naphthylacetato-κ
2
O,O′)(2,2′-bipyridine-κ
2
N,N′)lead(II)] monohydrate, C68H54N4O9Pb2
Authors: Deng Zheyu , Li Jiahong , Hou Xinbo , Luo Na , Zhu Xiaoming 
Published: March 2023

Abstract

C
68

H
54

N
4

O
9

P
b

2

${\mathrm{C}}_{68}{\mathrm{H}}_{54}{\mathrm{N}}_{4}{\mathrm{O}}_{9}{\mathrm{P}\mathrm{b}}_{2}$

, monoclinic, C2/c (no. 15), a = 15.7286(14) Å, b = 16.3623(14) Å, c = 22.500(2) Å, β =

97.369

(
1
)

°

$97.369(1){}^{\circ}$

, V = 5742.7(9)

Å
3

${\mathrm{\mathring{\text{A}}}}^{3}$

, Z = 4,

R

g
t

${R}_{gt}$

(F) = 0.0203, w

R

r
e
f

${R}_{ref}$

(

F
2

${F}^{2}$

) = 0.0488, T = 296(2) K.
Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic LeukodystrophyArsaKnock-Out Mice
Authors: St. Martin Thia , Seabrook Tania A. , Gall Katherine , Newman Jenn , Avila Nancy , Hayes April , Kivaa Monicah , Lotterhand Jason , Mercaldi Michael , Patel Kruti , Rivas Israel J. , Woodcock Stephen , Wright Teresa L. , Seymour Albert B. , Francone Omar L. , Gingras Jacinthe 
Published: March 2023

Metachromatic leukodystrophy (MLD) is a rare, inherited, demyelinating lysosomal storage disorder caused by mutations in the arylsulfatase-A gene (ARSA). In patients, levels of functional ARSA enzyme are diminished and lead to deleterious accumulation of sulfatides. Herein, we demonstrate that intravenous administration of HSC15/ARSArestored the endogenous murine biodistribution of the corresponding enzyme, and overexpression ofARSAcorrected disease biomarkers and ameliorated motor deficits inArsaKO mice of either sex. In treatedArsaKO mice, when compared with intravenously administered AAV9/ARSA,significant increases in brain ARSA activity, transcript levels, and vector genomes were observed with HSC15/ARSA. Durability of transgene expression was established in neonate and adult mice out to 12 and 52 weeks, respectively. Levels and correlation between changes in biomarkers and ARSA activity required to achieve functional motor benefit was also defined. Finally, we demonstrated blood–nerve, blood–spinal and blood–brain barrier crossing as well as the presence of circulating ARSA enzyme activity in the serum of healthy nonhuman primates of either sex. Together, these findings support the use of intravenous delivery of HSC15/ARSA-mediated gene therapy for the treatment of MLD.SIGNIFICANCE STATEMENTHerein, we describe the method of gene therapy adeno-associated virus (AAV) capsid and route of administration selection leading to an efficacious gene therapy in a mouse model of metachromatic leukodystrophy. We demonstrate the therapeutic outcome of a new naturally derived clade F AAV capsid (AAVHSC15) in a disease model and the importance of triangulating multiple end points to increase the translation into higher species via ARSA enzyme activity and biodistribution profile (with a focus on the CNS) with that of a key clinically relevant biomarker.
‘Gimme a Hell Yeah!’ Stone Cold Steve Austin and the WWF’s Soundscapes of Rage
Authors: Wells Christi Jay 
Published: March 2023

In the late 1990s, the Word Wrestling Federation (WWF) reached the height of its global popularity thanks to its “Attitude” re-branding. From 1997 to 2001, the company targeted an audience of teenagers and 18- to 34-year-old men with programming emphasizing adult themes and rebellious anti-heroes. The company’s most popular character at the time was “Stone Cold” Steve Austin, a beer-drinking Texas “redneck” who refused to conform and feuded on screen with a villainous corporate CEO. His iconic entrance music, “Hell Frozen Over,” was closely modeled on Rage Against the Machine’s 1996 hit song “Bulls on Parade” and played a crucial role in establishing the character’s credentials as a blue collar rebel whose actions channeled the desires of the WWF’s core audience of young white men.
Highlighting both the specific idiomatic conventions of professional wrestling entrance themes and the numerous similarities between “Bulls on Parade” and Austin’s entrance music, this article argues that Austin’s music leveraged sonic tropes of masculine anti-corporate rebellion that were legible as such in the late 1990s due largely to the soundscapes of rage popularized by RATM and the numerous rap-rock “nü metal” bands they inspired. It shows how Austin’s music and its RATM connection exemplify not only the capacity for popular entertainment to commodify rebellion, but also the agency of audiences in forging meaningful personal and interpersonal relationships with and through mass-mediated entertainment as sonic signifiers become disentangled from specific political movements and made available to a broad range of economic and political projects.
Home Planning and Gender in Mandatory Palestine
Authors: Davidi Sigal 
Published: March 2023

Abstract
The national Jewish awakening and the rise of Zionism set off several waves of Jewish immigration into Mandatory Palestine (1921–48), making housing an urgent issue. This article focuses on housing planning, using the lens of gender to explore the transfer and development of new household ideas from Germany to Palestine and the impact of these ideas on local housing debates. By tracing this process of knowledge transfer and contextualizing the kitchen discourse in Palestine within the context of contemporary European discourse, this study deepens our understanding of the development of Israeli home planning. Drawing on the professional opinions of architect Lotte Cohn and other women who described their own experiences in the home, it explores everyday aspects of the Zionist enterprise and how these intersected with the concept of the “new woman” in the Jewish community in Palestine.
PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway
Authors: Wang Tong‐Hong , Huang Kuo‐Yen , Chen Chin‐Chuan , Chang Ya‐Hsuan , Chen Hsuan‐Yu , Hsueh Chuen , Liu Yi‐Tsen , Yang Shuenn‐Chen , Yang Pan‐Chyr , Chen Chi‐Yuan 
Published: March 2023

AbstractParticulate matter 2.5 (PM2.5) is a risk factor for lung cancer. In this study, we investigated the molecular mechanisms of PM2.5 exposure on lung cancer progression. We found that short‐term exposure to PM2.5 for 24 h activated the EGFR pathway in lung cancer cells (EGFR wild‐type and mutant), while long‐term exposure of lung cancer cells to PM2.5 for 90 days persistently promoted EGFR activation, cell proliferation, anchorage‐independent growth, and tumor growth in a xenograft mouse model in EGFR‐driven H1975 cancer cells. We showed that PM2.5 activated AhR to translocate into the nucleus and promoted EGFR activation. AhR further interacted with the promoter of TMPRSS2, thereby upregulating TMPRSS2 and IL18 expression to promote cancer progression. Depletion of TMPRSS2 in lung cancer cells suppressed anchorage‐independent growth and xenograft tumor growth in mice. The expression levels of TMPRSS2 were found to correlate with nuclear AhR expression and with cancer stage in lung cancer patient tissue. Long‐term exposure to PM2.5 could promote tumor progression in lung cancer through activation of EGFR and AhR to enhance the TMPRSS2‐IL18 pathway.
Defect-free ZnO nanorods with high angular distribution for enhanced excitonic emission
Authors: Fiedler Saskia , Ton-That Cuong , Phillips Matthew R. 
Published: March 2023

AbstractLow-temperature hydrothermal growth has emerged as a popular method for the fabrication of ZnO nanorods (NRs), increasing the functionality and utility of ZnO-based devices. In this work, we study the influence of growth time, temperature and seed layer on the dimensions and angular distribution of ZnO NRs. High-quality NRs with a crisscrossed 60° angular distribution have been grown with a 20–60 nm diameter and 600 nm length. We show that, within the ideal range of growth parameters, the growth time and temperature have no controllable influence on NR diameter and length, while the deposition method and size of the pre-growth deposited ZnO seeds affects diameter and NR angular alignment. We demonstrate advantages of using crisscross-aligned NRs over planar ZnO for the enhancement of ZnO excitonic emission by optical coupling with gold nanoparticles. These results can be readily adapted for applications that involve surface coating-mediated enhancement of both light emission and injection.
Graphical abstract
Mechanical and leaching characterisation of impact-absorbing rubberised asphalts for urban pavements
Authors: Makoundou Christina , Fathollahi Alireza , Kleiven Svein , Coupe Stephen J , Sangiorgi Cesare 
Published: March 2023

AbstractA new impact-absorbing material is being developed to protect vulnerable road users in urban areas and has been produced and tested, mechanically and environmentally in the laboratory. The main constituent of this innovative material is the rubber recycled from end-of-life tyres to foster a circular use of resources and exploit rubber’s elastic properties. The study aims to provide a complete Uniaxial Compression Test (UCT) and leaching analysis of the material to propose and optimise a mix that is mechanically sound, durable, and respectful of the environment, in view of in-situ applications. Therefore, the UCT and Dynamic Surface Leaching Test (DSLT) were carried out on rubberised asphalt specimens with different mix designs. The 64 days cumulative concentrations of leached heavy metals and trace elements from unit surface of specimens were calculated and quantified, according to the CEN/TS 16637 standard. In parallel, thanks to a specific mechanical characterisation, compressive stress–strain curves were obtained, and the relaxation and elastic modulus were evaluated. The results from the compression tests showed that the A-mixes have the best elastic and absorbing behaviour, especially those made with an SBS-modified bituminous emulsion (A4). The results from DSLT showed that the cumulative concentration of released elements, per unit surface of specimens were lower than the Dutch Soil Quality Decree (SQD) thresholds, taken as a reference. The low and early release of leachant observed for the mixtures, especially A4 as the most promising one, leave the possibility to handle the leaching with several solutions, including rubber coating treatment or water washing before their incorporation into the mix to limit and prevent their leaching while permitting very high injury reduction performances.