bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanisms on how FABP5 inhibitors promote apoptosis‐induction sensitivity of prostate cancer cells
Authors: Zhang Jiacheng , He Gang , Jin Xi , Alenezi Bandar T. , Naeem Abdulghani A. , Abdulsamad Saud A. , Ke Youqiang 
Published: January 2023

AbstractPrevious work showed that FABP5 inhibitors suppressed the malignant progression of prostate cancer cells, and this suppression might be achieved partially by promoting apoptosis. But the mechanisms involved were not known. Here, we investigated the effect of inhibitors on apoptosis and studied the relevant mechanisms. WtrFABP5 significantly reduced apoptotic cells in 22Rv1 and PC3 by 18% and 42%, respectively. In contrast, the chemical inhibitor SB‐FI‐26 produced significant increases in percentages of apoptotic cells in 22Rv1 and PC3 by 18.8% (±4.1) and 4.6% (±1.1), respectively. The bio‐ inhibitor dmrFABP5 also did so by 23.1% (±2.4) and 15.8% (±3.0), respectively, in these cell lines. Both FABP5 inhibitors significantly reduced the levels of the phosphorylated nuclear fatty acid receptor PPARγ, indicating that these inhibitors promoted apoptosis‐induction sensitivity of the cancer cells by suppressing the biological activity of PPARγ. Thus, the phosphorylated PPARγ levels were reduced by FABP5 inhibitors, the levels of the phosphorylated AKT and activated nuclear factor kapper B (NFκB) were coordinately altered by additions of the inhibitors. These changes eventually led to the increased levels of cleaved caspase‐9 and cleaved caspase‐3; and thus, increase in the percentage of cells undergoing apoptosis. In untreated prostate cancer cells, increased FABP5 suppressed the apoptosis by increasing the biological activity of PPARγ, which, in turn, led to a reduced apoptosis by interfering with the AKT or NFκB signaling pathway. Our results suggested that the FABP5 inhibitors enhanced the apoptosis‐induction of prostate cancer cells by reversing the biological effect of FABP5 and its related pathway.
Long‐term follow‐up of contemporary drug‐eluting stent implantation in diabetic patients: Subanalysis of a randomized controlled trial
Authors: van Hemert Nicole D. , Voskuil Michiel , Rozemeijer Rik , Kraaijeveld Adriaan O. , Rittersma Saskia Z. , Leenders Geert E. H. , Stein Mèra , Frambach Peter , van der Harst Pim , Agostoni Pierfrancesco , Stella Pieter R. ,   The ReCre8 Study Investigators
Published: January 2023

AbstractObjectiveThe elevated risk of adverse events following percutaneous coronary intervention in diabetic patients persists with newer‐generation DES. The polymer‐free amphilimus‐eluting stent (PF‐AES) possesses characteristics with a potentially enhanced performance in patients with diabetes. Data from the 1‐year follow‐up period has been previously published. The aim of this subanalysis was to assess long‐term performance of two contemporary drug‐eluting stents (DES) in a diabetic population.MethodsIn the ReCre8 trial, patients were stratified for diabetes and troponin status, and randomized to implantation of a permanent polymer zotarolimus‐eluting stent (PP‐ZES) or PF‐AES. The primary endpoint was target‐lesion failure (TLF), a composite of cardiac death, target‐vessel myocardial infarction and target‐lesion revascularization. Clinical outcomes between discharge and 3 years follow‐up were assessed.ResultsA total of 302 patients with diabetes were included in this analysis. After 3 years, TLF occurred in 12.5% of PP‐ZES patients versus 10.0% in PF‐AES patients (p = 0.46). Similarly, the separate components of TLF were comparable between the two study arms. The secondary composite endpoint of NACE was higher in the PP‐ZES arm with 45 cases (29.6%) versus 30 cases (20.0%) in the PF‐AES arm (p = 0.036). In the insulin‐dependent diabetic population, TLF occurred in 19.1% of PP‐ZES patients versus 10.4% of PF‐AES patients (p = 0.21). NACE occurred in 40.4% of PP‐ZES patients versus 27.1% of PF‐AES patients (p = 0.10).ConclusionsThis subanalysis shows that the use of PF‐AES results in similar clinical outcomes as compared to PP‐ZES, yet some benefits of use of PF‐AES in diabetic patients may prevail. Future dedicated trials should confirm these findings.
Leaflet modification or chimney stenting in patients at risk for coronary artery obstruction in valve‐in‐valve procedure for a failed surgical bioprosthetic aortic valve
Authors: Montarello Nicholas J. , Quagliana Angelo , Søndergaard Lars , De Backer Ole 
Published: January 2023

AbstractValve‐in‐valve transcatheter aortic valve replacement (VIV‐TAVR) for a degenerated surgical aortic bioprosthesis is a well‐established treatment modality but carries an increased risk of coronary artery obstruction (CAO) with potentially catastrophic consequences. Both chimney stenting and leaflet modification by BASILICA (Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Obstruction) are increasingly employed and can be highly effective means of preventing CAO. Using a case report, in which both strategies were utilized, as a platform for detailed discussion, we address the indications, contraindications, and relative merits of each technique in the prevention of CAO.
Green and Fast Strategies for Energy‐Efficient Preparation of the Covalent Organic Framework TpPa‐1
Authors: Martínez‐Visus Íñigo , Ulcuango Matías , Zornoza Beatriz , Coronas Joaquín , Téllez Carlos 
Published: January 2023

AbstractThree synthesis procedures for the covalent‐organic framework (COF) TpPa‐1 are studied with the purpose of setting up the most promising one in a fast and green way, leading to a more environmentally friendly and sustainable process. With conventional heating, good crystallinity and a high BET specific surface area (SSA) of up to 1007 m2 ⋅ g−1 are achieved at 170 °C for 3 days using water as the quintessential green solvent. However, the application of microwave radiation in the synthesis for this crystalline porous polymer allows reaction times to be shortened to 30 min while maintaining structural and textural properties (BET SSA of 928 m2 ⋅ g−1) and obtaining yields close to 98 % (vs. 90 % in the hydrothermal synthesis). The water‐assisted mechanochemical synthesis is also an environmentally friendly synthetic approach; with heating at 170 °C in a two‐step process (10+10 min), high crystallinity is achieved, a BET SSA of 960  m2 ⋅ g−1 and a yield of 98 % for TpPa‐1.
Chiral explosives: A theoretical investigation of structure and chiroptical properties of triacetone triperoxide and hexamethylene triperoxide diamine
Authors: Puente Andrew R. , Polavarapu Prasad L. 
Published: January 2023

AbstractTriacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) are cyclic peroxides that exhibit atropisomerism resulting from restricted rotation around three peroxide bonds. As a result, one pair of enantiomers with D3 symmetry and another pair of enantiomers with C2 symmetry can be identified. Previous studies, based on mass spectrometry data and computational results, have shown that conformations of TATP with D3 and C2 symmetry can be isolated. Assuming that enantiomer samples of TATP and HMTD can be obtained with sufficient enantiopurity, we investigated their chiroptical properties, namely, optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and Raman optical activity (VROA). ORD curves and VCD spectra are seen to be very similar for D3‐ and C2‐symmetric atropisomers with the same overall helicity. Predicted VROA results, however, show significant differences between D3‐ and C2‐symmetric atropisomers with the same overall helicity. The D3‐symmetric atropisomer is predicted to exhibit considerably larger magnitude vibrational optical activity signals than the C2‐symmetric atropisomer.
Reconciling deep learning and first‐principle modelling for the investigation of transport phenomena in chemical engineering
Authors: Marcato Agnese , Marchisio Daniele , Boccardo Gianluca 
Published: January 2023

AbstractThe use of machine learning in chemical engineering has the potential to greatly improve the design and analysis of complex systems. However, there are also risks associated with its adoption, such as the potential for bias in algorithms and the need for careful oversight to ensure the safety and reliability of machine learning‐powered systems. This paper explores the opportunities and risks of using machine learning in chemical engineering and provides a perspective on how it may be integrated into engineering practices in a responsible and effective manner.We generated the text of this abstract with GPT‐3, OpenAI's large‐scale language‐generation model. Upon generating the draft, we ensured that the language was to our liking, and we take ultimate responsibility for the content of this publication.
Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery
Authors: Mousavi Maedehsadat , Salehi Zeinab , Rezvanpour Alireza , Mosayebi Mehdi , Farahani Masoumeh , Asadi Tokmedash Mohammad , Shokrgozar Mohammad Ali 
Published: January 2023

AbstractSmart drug delivery systems have attracted a lot of attention as one of the new treatment methods for cancer. In this study, a smart drug delivery system carrying anticancer drugs was obtained by the intelligent synthesis of glucosamine (GA)‐functionalized graphene oxide (GO)‐based iron oxide nanoparticles (Fe3O4@GO‐GA) using Hummers and chemical co‐precipitation processes. Nanohybrids have a high surface area (280.26 m2/g) and superparamagnetic behaviour (Ms = 26.017 emu/g), indicating a significant loading capacity (373.78 mg/mg) and efficiency (96.3%) for pharmaceutical loading. An adsorption study of conventional daunorubicin (DNR) on this carrier showed that the drug release is more prone to occur under acidic conditions (pH = 5.5), at moderately high temperatures (T = 40°C), and in the absence of smart carriers. The toxicity of the smart nanohybrids was examined using the sulphorhodamine B (SRB) assay in Michigan Cancer Foundation‐7 (MCF‐7) cell lines. The rate of death of cells exposed to smart drug‐containing systems in comparison to the systems without GA shows that GA reduces the toxicity of Fe3O4@GO.
Exploration of the Binding Modes of Toll‐Like Receptor 4 Competitive Inhibitors: A Combined Ligand‐Based and Target‐Based Approach
Authors: Dang Wen , Meng Churen , Wang Jian , Zhou Di , Chen Gang , Li Ning 
Published: January 2023

AbstractThe interactions of Toll‐like receptor 4 (TLR4) with competitive inhibitors were investigated by a combined ligand‐based and target‐based approach. Firstly, the ligand‐based pharmacophore model of the reported TLR4 inhibitors was constructed by utilizing the common feature method, which included three hydrophobic groups and a hydrogen bond receptor. The Schrödinger software suite glide module was used to dock inhibitors with proteins and verify the importance of these four interaction points from the target level. Then, molecular dynamics, alanine scanning mutagenesis, and binding free energy calculation were used to identify the key amino acids in the binding mode. In addition, blind docking proved that the TLR4 inhibitor does not bind to TLR4 itself like other TLR family proteins. Based on this, we also screened a class of sesquiterpene coumarins which possibly have TLR4 inhibitory activity and will conduct a detailed study later. Together, this study revealed the interactions between TLR4 protein and its competitive inhibitors, which shed light on better access for developing its novel inhibitors.
Formation and Surface Behavior of Pt and Pd Complexes with Ligand Systems Derived from Nitrile‐functionalized Ionic Liquids Studied by XPS
Authors: Hemmeter Daniel , Paap Ulrike , Taccardi Nicola , Mehler Julian , Schulz Peter S. , Wasserscheid Peter , Maier Florian , Steinrück Hans‐Peter 
Published: January 2023

AbstractThe front cover artwork is provided by the groups of Prof. Hans‐Peter Steinrück and Prof. Peter Wasserscheid at the Friedrich‐Alexander‐Universität (FAU) Erlangen‐Nürnberg. The image shows substitution of volatile acetonitrile ligands by a nitrile‐functionalized imidazolium cation. The formed cationic complex and the counter ions exhibit a specific preferential orientation at the ionic liquid/gas interface, which can be studied by angle‐resolved XPS. Read the full text of the Research Article at 10.1002/cphc.202200391.
Hepatitis E Virus: Isolation, Propagation, and Quantification
Authors: Lin Shaoli , Yang Liping , Zhang Yan‐Jin 
Published: January 2023

AbstractHepatitis E virus (HEV) predominantly causes acute liver disease in humans and is transmitted via the fecal‐oral route. HEV infection in pregnant women can result in grave consequences, with up to 30% fatality. The HEV strains infecting humans mainly belong to four genotypes. Genotypes 1 and 2 are restricted to human infection, while genotypes 3 and 4 are zoonotic. HEV genotype 3 (HEV‐3) can cause both acute and chronic liver disease. Several cell lines (mainly hepatocytes) have been developed for HEV propagation and biological study. However, HEV production in these cell lines is suboptimal and inefficient. Here, we present methods for the isolation, propagation, and quantification of HEV. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Isolation and propagation of hepatitis E virus in cultured cells from clinical HEV specimensSupport Protocol 1: Quantification of HEV RNA by RT‐qPCRBasic Protocol 2: Recovery of HEV from infectious cDNA clones and purification of the virusSupport Protocol 2: Quantification of HEV live particles by infectivity assay
The Colloidal Properties of Nanocellulose
Authors: Benselfelt Tobias , Kummer Nico , Nordenström Malin , Fall Andreas B. , Nyström Gustav , Wågberg Lars 
Published: January 2023

AbstractNanocelluloses are anisotropic nanoparticles of semicrystalline assemblies of glucan polymers. They have great potential as renewable building blocks in the materials platform of a more sustainable society. As a result, the research on nanocellulose has grown exponentially over the last decades. To fully utilize the properties of nanocelluloses, a fundamental understanding of their colloidal behavior is necessary. As elongated particles with dimensions in a critical nanosize range, their colloidal properties are complex, with several behaviors not covered by classical theories. In this comprehensive Review, we describe the most prominent colloidal behaviors of nanocellulose by combining experimental data and theoretical descriptions. We discuss the preparation and characterization of nanocellulose dispersions, how they form networks at low concentrations, how classical theories cannot describe their behavior, and how they interact with other colloids. We then show examples of how scientists can use this fundamental knowledge to control the assembly of nanocellulose into new materials with exceptional properties. We hope aspiring and established researchers will use this Review as a guide.
Real world evidence of clinical predictors of glycaemic response to glucose‐lowering drugs among Chinese with type 2 diabetes
Authors: Wu Hongjiang , Lau Eric S. H. , Yang Aimin , Fan Baoqi , Ma Ronald C. W. , Kong Alice P. S. , Chow Elaine , So Wing‐Yee , Chan Juliana C. N. , Luk Andrea O. Y. 
Published: January 2023

AbstractAimsTo examine whether simple clinical features can predict the 1‐year glycaemic response to glucose‐lowering drugs (GLDs) among Chinese with type 2 diabetes.Materials and MethodsWe used data from a diabetes risk assessment and complication screening programme and electronic medical records. We used linear regression models to examine the association between clinical features and 1‐year glycaemic response to GLDs.ResultsUse of metformin (n = 15,433), sulphonylureas (SU) (n = 15,190), dipeptidyl peptidase‐4 inhibitor (DPP‐4i) (n = 7947), thiazolidinedione (TZD) (n = 4107), and sodium‐glucose cotransporter 2 inhibitors (SGLT‐2i) (n = 1883) were associated with a mean reduction of HbA1c ranging from 0.7% to 1.3% at one year. Men had a greater response to SU but a poorer response to metformin and TZD. Older age predicted a better response to all GLDs but not SGLT‐2i, whereas increasing diabetes duration was associated with a poorer response to all GLDs except for DPP‐4i. Obese patients responded greater to TZD and SGLT‐2i but poorer to SU than those with normal weight. Patients with a higher level of triglycerides to high‐density lipoprotein cholesterol ratio had a greater glycaemic response to TZD but a smaller response to SU and DPP‐4i.ConclusionsGlycaemic response to GLDs differed considerably by clinical features among Chinese patients with type 2 diabetes.
Spatiotemporal variation in vegetation phenology and its response to climate change in marshes of Sanjiang Plain, China
Authors: Liu Yiwen , Shen Xiangjin , Zhang Jiaqi , Wang Yanji , Wu Liyuan , Ma Rong , Lu Xianguo , Jiang Ming 
Published: January 2023

AbstractSanjiang Plain is the largest marsh distribution area of China, and marshes in this region significantly affect regional carbon cycle and biodiversity protection. The vegetation phenology of marsh significantly affects the energy exchange and carbon cycle in that region. Under the influence of global climatic change, identifying the changes in phenology and their responses to climatic variation in marshes of Sanjiang Plain is essential for predicting the carbon stocks of marsh ecosystem in that region. Using climate and NDVI data, this paper analyzed the spatiotemporal variations in the start (SOS), end (EOS), and length (LOS) of vegetation growing season and explored the impacts of climatic variation on vegetation phenology in marshes of Sanjiang Plain. Results showed that the SOS advanced by 0.30 days/a, and EOS delayed by 0.23 days/a, causing LOS to increase significantly (p < .05) by 0.53 days/a over marshes of Sanjiang Plain. Spatially, the large SOS advance and EOS delay resulted in an obvious increasing trend for LOS in northern Sanjiang Plain. The rise of spring and winter temperatures advanced the SOS and increased the LOS, and the rise in temperature in autumn delayed the EOS in marshes of Sanjiang Plain. Our findings highlight the necessity of considering seasonal climatic conditions in simulating marsh vegetation phenology and indicate that the different influences of climatic variation on marsh vegetation phenology in different regions should be fully considered to assess the marsh ecosystem response to climatic change in Sanjiang Plain.
Validity and reliability of the Persian version of the Short‐Form Adolescent Health Promotion scale: Methodological study
Authors: Sarkhani Naeimeh , Pashaeypoor Shahzad , Negarandeh Reza , Ghafouryan Gomish Bashi Nazli , Heshmatian Mohammad Ehsan 
Published: January 2023

AbstractBackground and AimAssessing health promotion among adolescents is vital to identify healthy and unhealthy behaviors and to evaluate health promotion interventions. This study aimed to determine the validity and reliability of the Persian version of the Short‐Form Adolescent Health Promotion scale.MethodsThree hundred and twenty‐seven adolescents were recruited through a multistage sampling method in this methodological study. The original version of the Adolescent Health Promotion scale was translated from English to Persian using the Backward–Forward translation protocol. Then, the scale's validity and reliability, including the face, content, construct validity, and reliability indices, were evaluated. The statistical analysis was performed using SPSS software version 24.ResultsThe mean CVI and CVR were 0.99. The exploratory factor analysis revealed four factors covering 42.57% of the total variance. The factor loading order of the items did not exactly correspond to the order obtained in the English version of the scale's validity and reliability analysis. The obtained factors called included: life appreciation, stress management, nutrition, and health responsibility. In the current study, both Cronbach's ɑ and the intraclass correlation coefficient were calculated at 0.84 and 0.99.ConclusionThe Persian version of the Adolescent Health Promotion scale developed in the present study is acceptable for the validity of the content, face, and reliability. However, the construct validity of this scale should be checked in other samples.
Frequency of COVID‐19 vaccine side effects and its associated factors among the vaccinated population of Pakistan: A cross‐sectional study
Authors: Yasmin Farah , Najeeb Hala , Siddiqui Hasan Fareed , Asghar Muhammad Sohaib , Awan Hashir Ali , Usama Rana Muhammad , Allahuddin Zoha , Tahir Muhammad Junaid , Ullah Kaleem , Mahmmoud Fadelallah Eljack Mohammed 
Published: January 2023

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) vaccine side effects have an important role in the hesitancy of the general population toward vaccine administration. Therefore, this study was conducted to document the COVID‐19 vaccine side effects in our population.Materials and MethodsAn online survey‐based, cross‐sectional study was carried out from September 1, 2021, to October 1, 2021, to document the side effects of the COVID‐19 vaccine among the general public. The questionnaire included participants’ sociodemographic data, type of vaccine, comorbidities, previous COVID‐19 infection, and assessment of side effects reported by them.ResultsThe majority of the participants were <20 years of age (62.2%), females (74.9%), belonged to the educational sector (58.1%), residents of Sindh (65.7%), and were previously unaffected by COVID‐19 infection (73.3%). Sinovac (38.7%) followed by Sinopharm (30.4%) and Moderna (18.4%) were administered more frequently. Commonly reported side effects were injection site pain (82%), myalgia (55%), headache (46%), fatigue/malaise (45%), and fever (41%). Vaccine side effects were more likely to be reported with the first dose as compared to the second dose. On regression analysis, factors associated with occurrence of side effects included younger age (odds ratio [OR]: 6.000 [2.065–17.431], p < 0.001), female gender (OR: 2.373 [1.146–4.914], p = 0.020), marital status (OR: 0.217 [0.085–0.556], p < 0.001), graduate level of education (OR: 0.353 [0.153–0.816], p = 0.015), and occupation being either retired, freelancers, or social workers (OR: 0.310 [0.106–0.909]), p = 0.033). Previous infection with COVID‐19 (p = 0.458) and comorbidities were found unrelated (p = 0.707) to the occurrence of side effects.ConclusionThe overall prevalence of local side effects was quite higher than the systemic ones. Further large‐scale studies on vaccine safety are required to strengthen public confidence in the vaccination drive.
A risk–return trade‐off or co‐movement? Are food processing firms risk‐averse?
Authors: Mukherjee Subhadip , Mukherjee Soumyatanu , Parhi Mamata , Duan Kun , Usman Ahmed 
Published: January 2023

AbstractWe build a two‐moment decision‐theoretic framework to study how firms in the food‐processing industry negotiate between risk and return while relying on imported inputs for production at an intensive margin. Two possibilities emerge: either a co‐movement or a trade‐off in risk and return under various industry and economic conditions. Building on our theoretical setting, we design a testable empirical framework that considers a panel of 316 firms in the Indian food‐processing industry between 1993 and 2009. We find strong evidence of a decrease in the absolute risk aversion preference, although the magnitude varies measurably across firms.