bluuebunny/crossref_metadata_2025_split huggingface dataset:
NAFLD, MAFLD, and beyond: one or several acronyms for better comprehension and patient care
Authors: Portincasa Piero 
Published: February 2023

AbstractThe term non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common type of chronic liver disease. NAFLD points to excessive hepatic fat storage and no evidence of secondary hepatic fat accumulation in patients with “no or little alcohol consumption”. Both the etiology and pathogenesis of NAFLD are largely unknown, and a definitive therapy is lacking. Since NAFLD is very often and closely associated with metabolic dysfunctions, a consensus process is ongoing to shift the acronym NAFLD to MAFLD, i.e., metabolic-associated fatty liver disease. The change in terminology is likely to improve the classification of affected individuals, the disease awareness, the comprehension of the terminology and pathophysiological aspects involved, and the choice of more personalized therapeutic approaches while avoiding the intrinsic stigmatization due to the term “non-alcoholic”. Even more recently, other sub-classifications have been proposed to concentrate the heterogeneous causes of fatty liver disease under one umbrella. While awaiting additional validation studies in this field, we discuss the main reasons underlying this important shift of paradigm.
Sourcing energy services in business-to-business contexts: practices among end-customers
Authors: Poblete León , Halldórsson Árni 
Published: February 2023

AbstractFacing increased pressure to use renewable energy and achieve energy efficiency, organisations have the complex task of sourcing energy services from energy providers in business-to-business (B2B) contexts. We aimed to explore how customers in such contexts approach the sourcing of energy services. Our theoretical and empirical approach linked energy as a service offering and customer–provider interfaces used in sourcing energy services to elucidate the practices adopted in such sourcing by customers in B2B contexts. To that end, we employed a qualitative research approach using the Gioia methodology and conducted 18 semi-structured interviews with representatives of 18 firms in the B2B market for energy services in Sweden. Our results revealed two central categories of how energy services are sourced: basic and advanced. The theorising of those categories as forms of direct and indirect energy efficiency, combined with four types of energy services—information-, analysis-, improvement- and contract-oriented services, which include a description of energy services exchanged, where the customer uses the energy service, the customer’s sourcing practices and characteristics of sourcing practices—provides important contributions to the literature on energy services. In turn, we propose a four-part typology of interfaces used by providers and customers of energy services that considers the type of services sourced.
Connectivity and Order: an Analytical Framework
Authors: Gaens Bart , Sinkkonen Ville , Vogt Henri 
Published: February 2023

AbstractIR literature has become inundated with different descriptions for the future of international order. The coming age is purportedly marked by China’s ascendancy, American decline, a leaderless “no-one’s world”, or multiple competing modernities. Yet the global fight against climate change or shared COVID-19 strategies convey a different image of the world’s predicament. The situation appears paradoxical: increasingly tense great-power relations are mixed with ever-strengthening interdependencies. This article contributes to these debates by exploring how global orders as well as regionalism today are increasingly defined by various types of connective functional links between intentional actors at various levels of social organisation. To enable a nuanced analysis, the article introduces an analytical framework composed of sixconnectivitylogics, namely cooperation, copying, cushioning, contestation, containment, and coercion. These play out differently within material, economic, institutional, knowledge, people-to-people, and security spheres. The utility of this article’s approach is demonstrated through empirical examples related to the policies of key actors in the Indo-Pacific region.
Drinking motives as a predictor of readiness to change alcohol use
Authors: Moustafa Ahmed A. , Alvinia Nadia P. , Liu Liquan , Richard Yuliya , Hanafy Ali A. , Bagadood Nizar H. , Hamza Eid Abo 
Published: February 2023

AbstractDrinking motives have been identified as important predictors of alcohol consumption. Similarly, the degree of readiness to change (RTC) can predict behavioral changes when drinking alcohol. However, the link between drinking motives and RTC has not been explored in previous research. The aim of this study is to investigate whether the four drinking motives (coping, enhancement, social, conformity) can predict the three stages of RTC (precontemplation, contemplation and action) in relation to alcohol consumption. Two hundred and fifty-two undergraduates’ students completed an online self-assessment survey on Qualtrics that assessed motives for alcohol use, drinking behavior, and RTC. Hierarchical regressions showed that among the four specific drinking motives, coping motives significantly predicted all three stages of RTC; conformity motives positively predicted the action stage of change; social motives negatively predicted the precontemplation and action stages of change; enhancement motives were not significant in predicting RTC stages. These results indicate that the three RTC levels can be predicted by coping, social, and conformity motives, but not by enhancement motives. Additionally, given the importance of coping motives, it might be useful to address and include healthier coping mechanisms as part of clinical interventions and prevention methods to circumvent unsafe drinking behaviors independent of a single RTC stage.
Conceptualizing anxiety and depression in children and adolescents: a latent factor and network analysis
Authors: Junghänel Michaela , Thöne Ann-Kathrin , Dose Christina , Breuer Dieter , Görtz-Dorten Anja , Döpfner Manfred 
Published: February 2023

AbstractThe objective of this study is to gain insight into the inherent structure of anxiety and depressive symptoms by combining the strengths of latent factor analysis and network analysis. The sample comprised 743 children and adolescents aged 4–18 years (M = 11.64, SD = 3.66, 61% males) who sought routine care outpatient psychotherapy. Parents or primary caregivers rated anxiety and depressive symptoms of their children on a DSM-5-/ICD-10-based symptom checklist. First, we analyzed the factor structure of the internalizing symptoms using exploratory factor analysis (EFA). Next, we conducted a network analysis and identified central and bridge symptoms that may explain comorbidity between anxiety disorders and depression. We then employed exploratory graph analysis (EGA) as an alternative tool within the framework of network psychometrics to estimate the number of dimensions (i.e., communities within a network). Finally, we tested a model based on these results using confirmatory factor analysis. The results demonstrate a complex interplay between anxiety and depressive symptom domains. Four factors/communities were identified by EFA and EGA, but the item-community allocation differed, and the interpretation of factors/communities was unclear. A clear distinction between these domains could not be supported. However, associations within a domain were stronger than associations between the two domains. We identified pain, suicidal, irritable, and afraid of adults as bridge items between the symptom domains. In conclusion, our findings further advance the general understanding of the frequently reported co-occurrence of anxiety and depressive symptoms and diagnoses in clinical practice. Identifying bridge symptoms may inform intervention practices by targeting specific symptoms that contribute to the maintenance of anxious and depressive behaviors.
The Landscape of Neutralizing Monoclonal Antibodies (nAbs) for Treatment and Prevention of COVID-19
Authors: de Almeida Oliveira Aline , Praia Borges Freire Diana , Rodrigues de Andrade Ana , de Miranda Marques Amanda , da Silva Madeira Luciana , Moreno Senna José Procópio , Freitas Brasileiro da Silveira Ivna Alana , de Castro Fialho Beatriz 
Published: February 2023

Abstract
Purpose
After nearly 3 years of the COVID-19 pandemic, even though a vast body of knowledge and products (including vaccines and treatments) have been developed and disseminated, the virus is still evolving and new variants arising. Consequently, thousands of lives continue to be lost. Neutralizing monoclonal antibodies (nAbs) are promising drugs that emerged to treat SARS-CoV-2. In the uncertainty of the current situation, there is the question of whether organizations should continue to invest in this technology. To help decision-making in scientifical and pharmaceutical organizations, it is of major importance to monitor the development of products and technologies. Therefore, the aim of this study is analyze the landscape of nAbs for COVID-19.

Methods
The scenario of 473 biotherapeutics focusing on nAbs was evaluated using foresight techniques and a review of literature. Data were obtained from structured and semi-structured databases and processed for treatment, cleaning, consistency, validation, and enrichment.

Results
We identified 227 nAbs and performed an extensive literature review of 16 nAbs in late clinical development, including development technologies, responses to variants of concern (VOCs), manufacturing, and clinical aspects.

Conclusions
Even though the emergence of new VOCs is a threat to the effectiveness of this treatment, demanding constant genomic surveillance, the use of nAbs to treat and prevent COVID-19 will probably continue to be relevant due to excellent safety profiles and the possibility of immediate immunity transfer, especially in patients showing inadequate immunological response to vaccination. Therefore, we suggest that organizations should keep investing in improvements in this technology.
Commensurate stacking within confined ultramicropores boosting acetylene storage capacity and separation efficiency
Authors: Huang Zhenghui , Chai Kungang , Kang Chengjun , Krishna Rajamani , Zhang Zhaoqiang 
Published: February 2023

AbstractDeveloping advanced porous materials possessing both a high storage capacity and selectivity for acetylene (C2H2) remains challenging but a sought-after endeavor. Herein we show a strategy involving synergic combination of spatial confinement and commensurate stacking for enhanced C2H2storage and capture via maximizing the host—guest and guest—guest interactions. Two ultramicroporous metal-organic frameworks (MOFs), MIL-160 and MOF-303 are elaborately constructed to exhibit ultrahigh C2H2uptakes of 235 and 195 cm3·g−1, respectively, due to the confinement effect of the suitable pore sizes and periodically dispersed molecular recognition sites. Specially, C2H2capacity of MIL-160 sets a new benchmark for C2H2storage. The exceptional separation performances of two materials for C2H2over both CO2and ethylene (C2H4), which is rarely observed, outperform most of the benchmark materials for C2H2capture. We scrutinized the origins of ultrahigh C2H2loading in the confined channels via theoretical investigations. The superior separation efficiency for C2H2/CO2and C2H2/C2H4mixtures with unprecedented C2H2trapping capacity (> 200 L·kg−1) was further demonstrated by dynamic breakthrough experiments.
Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study
Authors: Kou Kou , Cameron Jessica , Youl Philippa , Pyke Chris , Chambers Suzanne , Dunn Jeff , Aitken Joanne F. , Baade Peter D. 
Published: February 2023

Abstract
Background
Interval breast cancers (BC) are those diagnosed within 24 months of a negative mammogram. This study estimates the odds of being diagnosed with high-severity BC among screen-detected, interval, and other symptom-detected BC (no screening history within 2 years); and explores factors associated with being diagnosed with interval BC.

Methods
Telephone interviews and self-administered questionnaires were conducted among women (n = 3,326) diagnosed with BC in 2010–2013 in Queensland. Respondents were categorised into screen-detected, interval, and other symptom-detected BCs. Data were analysed using logistic regressions with multiple imputation.

Results
Compared with screen-detected BC, interval BC had higher odds of late-stage (OR = 3.50, 2.9–4.3), high-grade (OR = 2.36, 1.9–2.9) and triple-negative cancers (OR = 2.55, 1.9–3.5). Compared with other symptom-detected BC, interval BC had lower odds of late stage (OR = 0.75, 0.6–0.9), but higher odds of triple-negative cancers (OR = 1.68, 1.2–2.3). Among women who had a negative mammogram (n = 2,145), 69.8% were diagnosed at their next mammogram, while 30.2% were diagnosed with an interval cancer. Those with an interval cancer were more likely to have healthy weight (OR = 1.37, 1.1–1.7), received hormone replacement therapy (2–10 years: OR = 1.33, 1.0–1.7; > 10 years: OR = 1.55, 1.1–2.2), conducted monthly breast self-examinations (BSE) (OR = 1.66, 1.2–2.3) and had previous mammogram in a public facility (OR = 1.52, 1.2–2.0).

Conclusion
These results highlight the benefits of screening even among those with an interval cancer. Women-conducted BSE were more likely to have interval BC which may reflect their increased ability to notice symptoms between screening intervals.
Efficiently computing the Shapley value of connectivity games in low-treewidth graphs
Authors: van der Zanden Tom C. , Bodlaender Hans L. , Hamers Herbert J. M. 
Published: February 2023

AbstractThe Shapley value is the solution concept in cooperative game theory that is most used in both theoretical and practical settings. Unfortunately, in general, computing the Shapley value is computationally intractable. This paper focuses on computing the Shapley value of (weighted) connectivity games. For these connectivity games, which are defined on an underlying (weighted) graph, computing the Shapley value is $$\#\textsf {P}$$

#
P

-hard, and thus (likely) intractable even for graphs with a moderate number of vertices. We present an algorithm that can efficiently compute the Shapley value if the underlying graph has bounded treewidth. Next, we apply our algorithm to several real-world (covert) networks. We show that our algorithm can quickly compute exact Shapley values for these networks, whereas in prior work these values could only be approximated using a heuristic method. Finally, it is demonstrated that our algorithm can also efficiently compute the Shapley value time for several larger (artificial) benchmark graphs from the PACE 2018 challenge.
Influence of new general relativity parameters on the Big Rip–Big Crunch Model
Authors: Ibraheem Shymaa K. , Bakry M. A. 
Published: February 2023

AbstractIn this article, the field equations of new general relativity, constructed by Hayashi and Shirafuji, contain three free parameters. These field equations have been applied to the Friedmann–Robertson–Walker metric in the domain of cosmology. In the application, a family of models, involving two of the parameters characterizing the field equations of new general relativity, is obtained. Conditions are placed on these parameters in order for the model to be compatible with the Big Rip or Big Crunch models. These models refer to original relativistic models of relativity theory if the parameters characterizing the field equations are equal to unity. The exact solutions are obtained under a specific choice of the parameters characterizing the field equations and the quadratic deceleration parameter. Radiation, dust, dark energy, vacuum, and phantom universes are obtained from field equations,and these models are not affected by the field parameters. Energy conditions, as well as the effective potential of the proposed models, are discussed.
Perspectives of Indigenous University Students in Canada on Mindfulness-Based Interventions and their Adaptation to Reduce Depression and Anxiety Symptoms
Authors: Beshai Shadi , Desjarlais Sharon M. , Green Brenda 
Published: February 2023

AbstractObjectivesIndigenous university students experience high rates of anxiety and depression due primarily to the pernicious and persistent effects of colonialism, racism, and discrimination. Mindfulness-based interventions (MBIs) hold promise, but likely require adaptation to make them culturally relevant for Indigenous peoples. We sought to gather Indigenous students’ perspectives on the consistency and adaptability of MBIs for Indigenous students experiencing symptoms of depression and anxiety.MethodThis three-part longitudinal investigation employed a qualitative design mixed with Indigenous research methods to elicit feedback from students (n = 14;Mage = 28.92) on the acceptability of MBIs and ways to tailor MBIs to make them more consistent with Indigenous cultures and student lifestyles. We subsequently used this feedback to develop an outline for an adapted MBI that was then re-evaluated by the same participants for its cultural relevance and safety.ResultsIndigenous students emphasized the need for the adapted MBI to incorporate (a) traditional Indigenous practices; (b) Indigenous facilitators; (c) holistic conceptualizations of mental health that include spirituality; and (d) practices and methods that could improve flexibility and accessibility of the adapted intervention. Based on this feedback, we presented students with an outline of an adapted MBI tentatively titledMiyowâyâwin Mindful Wellbeing Program, which received favorable evaluations by students for cultural consistency and safety.ConclusionsWe confirmed the perceived acceptability and consistency of mindfulness and mindfulness programs with Indigenous cultures. The need for a flexible MBI that centers Indigenous elements and Indigenous facilitators was highlighted by Indigenous participants. This study paves the way for latter steps of the development and subsequent evaluation of theMiyowâyâwin Mindful Wellbeing Program.PreregistrationThis study is not preregistered.
Do Mathematicians Agree about Mathematical Beauty?
Authors: Sa Rentuya , Alcock Lara , Inglis Matthew , Tanswell Fenner Stanley 
Published: February 2023

Abstract
Mathematicians often conduct aesthetic judgements to evaluate mathematical objects such as equations or proofs. But is there a consensus about which mathematical objects are beautiful? We used a comparative judgement technique to measure aesthetic intuitions among British mathematicians, Chinese mathematicians, and British mathematics undergraduates, with the aim of assessing whether judgements of mathematical beauty are influenced by cultural differences or levels of expertise. We found aesthetic agreement both within and across these demographic groups. We conclude that judgements of mathematical beauty are not strongly influenced by cultural difference, levels of expertise, and types of mathematical objects. Our findings contrast with recent studies that found mathematicians often disagree with each other about mathematical beauty.
Nested modalities in astrophysical modeling
Authors: Castellani Elena , Schettino Giulia 
Published: February 2023

AbstractIn the context of astrophysical modeling at the solar system scale, we investigate the modalities implied by taking into account different levels of detail at which phenomena can be considered. In particular, by framing the analysis in terms of the how-possibly/how-actually distinction, we address the debated question as to whether the degree of plausibility is tightly linked to the degree of detail. On the grounds of concrete examples, we argue that, also in the astrophysical context examined, this is not necessarily the case.
Oligoetherols and polyurethane foams based on cyclotriphosphazene of reduced flammability
Authors: Lubczak Jacek , Lubczak Renata 
Published: February 2023

AbstractNew oligoetherols with based on cyclotriphosphazene ring were synthesized by functionalization of hexachlorocyclotriphosphazene with glycidol followed by reaction with ethylene glycol and glycerol. Oligoetherols were characterized by IR, 1H-NMR, and MALDI-ToF and hydroxyl number as well as physical properties like density, viscosity and surface tension. The oligoetherols were further converted into polyurethane foams. The rigid foams of enhanced thermal stability and considerably diminished flammability were obtained and their apparent density, water uptake and polymerization shrinkage, thermal conductivity coefficient and thermal stability were determined. The flammability of foams was studied by microcalorimetric methods, horizontal flaming test and oxygen index. The obtained polyurethane foams with incorporated cyclotriphosphazene ring are self-extinguishing.
Graphical abstract
Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression
Authors: Sousa André , Coelho Pedro , Leite Fernanda , Teixeira Catarina , Rocha Ana Catarina , Santos Inês , Baylina Pilar , Fernandes Ruben , Soares Raquel , Costa Raquel , Gomes Andreia 
Published: February 2023

AbstractProstate cancer (PCa) is the second most common malignancy in men, and the fifth leading cause of death worldwide. Mesenchymal stromal/stem cells (MSC) have been identified in PCa, although contradictory effects in malignant transformation and tumor progression have been described. Since umbilical cord (UC) MSC and cord blood serum (CBS) are rich in numerous growth and anti-inflammatory factors, UC-MSC secretome and CBS are able to modulate tumor cell proliferation and survival as well as immunity and angiogenesis. In the present study, we address this relationship and investigate the influence of UC-MSC secretome and CBS on two human PCa cell lines (PC3 and LNCaP) and a normal epithelial prostate cell line (HPEpiC). Our results disclosed that upon exposure to UC-MSC-conditioned medium or CBS, both PC3 and LNCaP cells exhibited reduced viability, proliferation, and motility while non-malignant epithelial prostate cells were unaffected. These findings were corroborated by expression analysis of AKT/PI3K signaling pathway, p53 and interleukin genes. UC-MSC and CBS factors decreased the expression of growth-stimulating AKT and PI3K effectors and simultaneously up-regulated the expression of tumor-suppressor p53. Moreover, a more anti-inflammatory expression profile was found in both malignant PCa cell lines. Altogether, these results shed light into possible mechanisms by which UC-MSC and CBS reduce PCa progression, further reinforcing their potential use as novel therapeutic agents in PCa.
Graphical abstract