bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health and economic benefits of achieving contraceptive and maternal health targets in Small Island Developing States in the Pacific and Caribbean
Authors: Kelly Sherrie L , Walsh Tom , Delport Dominic , ten Brink Debra , Martin-Hughes Rowan , Homer Caroline SE , Butler Jennifer , Adedeji Olanike , De Beni Davide , Maurizio Federica , Friedman Howard S , Di Marco Doretta , Tobar Federico , de la Corte Molina Maria Pilar , Richards Andre S , Scott Nick 
Published: February 2023

IntroductionReducing unmet need for modern contraception and expanding access to quality maternal health (MH) services are priorities for improving women’s health and economic empowerment. To support investment decisions, we estimated the additional cost and expected health and economic benefits of achieving the United Nations targets of zero unmet need for modern contraceptive choices and 95% coverage of MH services by 2030 in select Small Island Developing States.MethodsFive Pacific (Kiribati, Samoa, Solomon Islands, Tonga and Vanuatu) and four Caribbean (Barbados, Guyana, Jamaica and Saint Lucia) countries were considered based on population survey data availability. For each country, the Lives Saved Tool was used to model costs, health outcomes and economic benefits for two scenarios: business-as-usual (BAU) (coverage maintained) and coverage-targets-achieved, which scaled linearly from 2022 (following COVID-19 disruptions) coverage of evidence-based family planning and MH interventions to reach United Nations targets, including modern contraceptive methods and access to complete antenatal, delivery and emergency care. Unintended pregnancies, maternal deaths, stillbirths and newborn deaths averted by the coverage-targets-achieved scenario were converted to workforce, education and social economic benefits; and benefit–cost ratios were calculated.ResultsThe coverage-targets-achieved scenario required an additional US$12.6M (US$10.8M−US$15.9M) over 2020–2030 for the five Pacific countries (15% more than US$82.4M to maintain BAU). This additional investment was estimated to avert 126 000 (40%) unintended pregnancies, 2200 (28%) stillbirths and 121 (29%) maternal deaths and lead to a 15-fold economic benefit of US$190.6M (US$67.0M−US$304.5M) by 2050. For the four Caribbean countries, an additional US$17.8M (US$15.3M−US$22.4M) was needed to reach the targets (4% more than US$405.4M to maintain BAU). This was estimated to avert 127 000 (23%) unintended pregnancies, 3600 (23%) stillbirths and 221 (25%) maternal deaths and lead to a 24-fold economic benefit of US$426.2M (US$138.6M−US$745.7M) by 2050.ConclusionAchieving full coverage of contraceptive and MH services in the Pacific and Caribbean is likely to have a high return on investment.
Advance consent for participation in randomised controlled trials for emergency conditions: a scoping review
Authors: Niznick Naomi , Lun Ronda , Dewar Brian , Perry Jeffrey , Dowlatshahi Dar , Shamy Michel 
Published: February 2023

ObjectiveAdvance consent is a recognised method of obtaining informed consent for participation in research, whereby a potential participant provides consent for future involvement in a study contingent on qualifying for the study’s inclusion criteria on a later date. The goal of this study is to map the existing literature on the use of advance consent for enrolment in randomised controlled trials (RCTs) for emergency conditions.DesignScoping review designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses–Extension for Scoping Reviews guidelines.Data sourcesWe searched electronic databases including MEDLINE, Embase, Web of Science and the Cochrane Register of Clinical Trials from inception to 10 February 2020.Eligibility criteriaEligible studies included articles that discussed or employed the use of advance consent for enrolment in RCTs related to emergency conditions. There were no restrictions on the type of eligible study. Data were extracted directly from included papers using a standardised data charting form. We produced a narrative review including article type and authors’ dispositions towards advance consent.ResultsOur search yielded 1039 titles with duplicates removed. Six articles met inclusion criteria. Three articles discussed the theoretical use of research advance directives in emergency conditions; one article evaluated stakeholders’ perceptions of advance consent; and one article described a method for patients to document their preferences for participation in future research. Only one study employed advance consent to enrol participants into a clinical trial for an emergency condition.ConclusionOur review demonstrates that there has been minimal exploration of advance consent for enrolment in RCTs for emergency conditions. Future studies could aim to assess the acceptability of advance consent to participants, along with the feasibility of enrolling research participants using this method of consent.ProtocolThe protocol for this scoping review was published a priori.
Effects of self-disclosure and resilience on reproductive concern in patients of childbearing age with breast cancer: a cross-sectional survey study
Authors: Zhu Hong , Tao Lin , Hu Xiaoxia , Jiang Xiaolian 
Published: February 2023

ObjectivesTo assess reproductive concerns in patients of childbearing age with breast cancer and examine the relationship between self-disclosure, resilience and reproductive concerns.DesignCross-sectional survey.SettingFive tertiary first-class general hospitals in Sichuan Province, Southwest China.ParticipantsA total of 319 patients with breast cancer of reproductive age who were hospitalised in the breast oncology department participated in this study.Main outcome measuresPrimary outcomes were the relationship between resilience, self-disclosure and reproductive concerns, and mediating effect analyses. Secondary outcomes included the status of reproductive concerns.ResultsThe model accounted for 39.1% of the variance in reproductive concerns. Self-disclosure had a direct negative effect on reproductive concerns (β= −0.371, p=0.001). Resilience had a direct negative effect on reproductive concerns (β= −0.349, p=0.001) and a direct positive effect on self-disclosure (β=0.507, p=0.001). Furthermore, self-disclosure partially mediated the relation between resilience and reproductive concerns (β= −0.177; SE=0.041; 95% CI −0.261 to –0.104; p<0.050), with a bootstrap of 10 000 samples.ConclusionsThe ﬁndings suggest that self-disclosure and resilience may ease reproductive concern. Therefore, self-disclosure education and resilience-oriented interventions should be provided to patients of childbearing age with breast cancer, to reduce reproductive concerns.
Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis
Authors: DiVita Dean Bayli , Wildes Tyler , Dean Joseph , Yegorov Oleg , Yang Changlin , Shin David , Francis Connor , Figg John W , Sebastian Mathew , Font Laura Falceto , Jin Dan , Reid Alexandra , Moore Ginger , Fernandez Brandon , Wummer Brandon , Kuizon Carmelle , Mitchell Duane , Flores Catherine T 
Published: February 2023

BackgroundGlioma-induced immune dysregulation of the hematopoietic system has been described in a limited number of studies. In this study, our group further demonstrates that gliomas interrupt the cellular differentiation programming and outcomes of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. HSPCs from glioma-bearing mice are reprogrammed and driven towards expansion of myeloid lineage precursors and myeloid-derived suppressor cells (MDSCs) in secondary lymphoid organs. However, we found this expansion is reversed by immunotherapy. Adoptive cellular therapy (ACT) has been demonstrably efficacious in multiple preclinical models of central nervous system (CNS) malignancies, and here we describe how glioma-induced dysfunction is reversed by this immunotherapeutic platform.MethodsThe impact of orthotopic KR158B-luc glioma on HSPCs was evaluated in an unbiased fashion using single cell RNAseq (scRNAseq) of lineage−cells and phenotypically using flow cytometry. Mature myeloid cell frequencies and function were also evaluated using flow cytometry. Finally, ACT containing total body irradiation, tumor RNA-pulsed dendritic cells, tumor-reactive T cells and HSPCs isolated from glioma-bearing or non-tumor-bearing mice were used to evaluate cell fate differentiation and survival.ResultsUsing scRNAseq, we observed an altered HSPC landscape in glioma-bearing versus non-tumor-bearing mice . In addition, an expansion of myeloid lineage subsets, including granulocyte macrophage precursors (GMPs) and MDSCs, were observed in glioma-bearing mice relative to non-tumor-bearing controls. Furthermore, MDSCs from glioma-bearing mice demonstrated increased suppressive capacity toward tumor-specific T cells as compared with MDSCs from non-tumor-bearing hosts. Interestingly, treatment with ACT overcame these suppressive properties. When HSPCs from glioma-bearing mice were transferred in the context of ACT, we observed significant survival benefit and long-term cures in orthotopic glioma models compared with mice treated with ACT using non-glioma-bearing HSPCs.
Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report
Authors: de Joode Karlijn , Veenbergen Sharon , Kransse Claudia , Kortleve Dian , Debets Reno , Mathijssen Ron H J , Joosse Arjen , Schreurs Marco W J , Van der Veldt Astrid A M 
Published: February 2023

In 2019, Fässleret alshowed in this journal that the presence of tumor-associated antibodies correlated with response to immune checkpoint inhibitor treatment in patients with metastatic melanoma. The results of this study suggested that tumor-associated antibodies directed against melanocyte-differentiation antigens and the cancer-germline antigen NY-ESO-1 should be further investigated as candidate biomarkers for response to immune checkpoint inhibitors. The aim of the current study was to validate and extend these previous findings. Therefore, we examined the correlation between serum levels of tumor-associated antibodies and tumor response after treatment with immune checkpoint inhibitors in patients with metastatic melanoma.All patients included in this prospective study were diagnosed with advanced stage melanoma and treated with nivolumab or pembrolizumab monotherapy. Blood samples were collected before and during treatment. Serum levels of tumor-associated antibodies against the melanocyte differentiation antigen Melan-A and the cancer germline antigens NY-ESO-1, MAGE-C2, MAGE-A6 and ROPN1B were measured at baseline and during treatment. Differences between responders and non-responders were assessed using the Mann-Whitney U-test, and differences between different overall survival categories with the Kruskal-Wallis test. P values ≤0.05 were considered significant.Serum samples of 58 patients with advanced melanoma with long-term follow-up (>3 years) were collected. In contrast to the findings of Fässleret al, for all antibodies tested, we found no significant differences between serum levels of responders and non-responders before or during treatment with immune checkpoint inhibitors. In addition, no significant differences were found in serum levels of tumor-associated antibodies for different overall survival groups.Although our study included a larger and more mature cohort of patients with longer follow-up, we could not externally validate the findings of Fässleret al. In addition, we were not able to identify other cancer germline antigens as predictive biomarkers of response to immune checkpoint inhibitors in patients advanced melanoma. Based on the results of the present study, clinical applicability of tumor-associated antibodies directed against tumor antigens as predictive biomarkers for immune checkpoint inhibitors in patients with advanced melanoma is not feasible.
First-principle calculation of birefringence effects for in-ice radio detection of neutrinos
Authors: Heyer Nils , Glaser Christian 
Published: February 2023

AbstractThe detection of high-energy neutrinos in the EeV range requires new detection techniques to cope with the small expected flux. The radio detection method, utilizing Askaryan emission, can be used to detect these neutrinos in polar ice. The propagation of the radio pulses has to be modeled carefully to reconstruct the energy, direction, and flavor of the neutrino from the detected radio flashes. Here, we study the effect of birefringence in ice, which splits up the radio pulse into two orthogonal polarization components with slightly different propagation speeds. This provides useful signatures to determine the neutrino energy and is potentially important to determine the neutrino direction to degree precision. We calculated the effect of birefringence from first principles where the only free parameter is the dielectric tensor as a function of position. Our code, for the first time, can propagate full RF waveforms, taking interference due to changing polarization eigenvectors during propagation into account. The model is available open-source through the NuRadioMC framework. We compare our results to in-situ calibration data from the ARA and ARIANNA experiments and find good agreement for the available time delay measurements. This indicates a significant improvement of the prediction power of birefringence effects compared to previous models. Finally, the implications and opportunities for neutrino detection are discussed.
Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity
Authors: Steinkamp Mara P. , Lagutina Irina , Brayer Kathryn J. , Schultz Fred , Burke Danielle , Pankratz Vernon S. , Adams Sarah F. , Hudson Laurie G. , Ness Scott A. , Wandinger-Ness Angela 
Published: February 2023

Abstract

The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies. To leverage the power of patient-derived xenograft (PDX) models within a humanized immune microenvironment, three ovarian cancer PDXs were grown in humanized NBSGW (huNBSGW) mice engrafted with human CD34+ cord blood–derived hematopoietic stem cells. Analysis of cytokine levels in the ascites fluid and identification of infiltrating immune cells in the tumors demonstrated that these humanized PDX (huPDX) established an immune tumor microenvironment similar to what has been reported for patients with ovarian cancer. The lack of human myeloid cell differentiation has been a major setback for humanized mouse models, but our analysis shows that PDX engraftment increases the human myeloid population in the peripheral blood. Analysis of cytokines within the ascites fluid of huPDX revealed high levels of human M-CSF, a key myeloid differentiation factor as well as other elevated cytokines that have previously been identified in ovarian cancer patient ascites fluid including those involved in immune cell differentiation and recruitment. Human tumor-associated macrophages and tumor-infiltrating lymphocytes were detected within the tumors of humanized mice, demonstrating immune cell recruitment to tumors. Comparison of the three huPDX revealed certain differences in cytokine signatures and in the extent of immune cell recruitment. Our studies show that huNBSGW PDX models reconstitute important aspects of the ovarian cancer immune tumor microenvironment, which may recommend these models for preclinical therapeutic trials.

Significance:
huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.
Intertextualidade na forma musical em três obras de Tatiana Catanzaro
Authors: Santos Jorge Luiz de Lima 
Published: February 2023

O artigo pretende discutir o modo como a compositora brasileira Tatiana Catanzaro pensa a questão da forma por meio da análise de três de suas obras. O interesse do trabalho é entender como o problema da forma se apresenta no processo criativo da compositora. Para esse objetivo, foi realizada entrevista com Catanzaro, aliado a pesquisa bibliográfica e análise de suas obras. Conceitos como intertextualidade e transdução aparecem como possibilidades interpretativas que permitem tanto esboçar uma ideia da microforma, elemento mais fundamental para Catanzaro, quanto da macroforma. Nas três obras aqui analisadas - A Dream within a Dream, Ijahereni, Andma shajarat al-Hayah tanmow fi al-Sahra Yahi – é comum o uso da intertextualidade como ponto de partida para criação das peças. É possível afirmar que a forma no processo criativo de Catanzaro se realiza como forma em processo, resultante da exploração do material sonoro inicial.
A test of associative olfactory learning in the ant Formica clara (Hymenoptera: Formicidae); the power of a MaLER-based conditioning protocol
Authors: Duymaz Kubilay , Aksoy Volkan 
Published: February 2023

Abstract
In the present study, we tested associative olfactory learning performance of the ant Formica clara in laboratory conditions based on their MaLER responses. Ants were harnessed with the help of a paper-made holder and conditioned in two groups by forward pairing either limonene or eugenol (conditioned stimuli – CS) with a reward (unconditioned stimulus – US). After conditioning, memory tests were performed for each CS 15, 60 and 90 minutes following the conditioning in the absence of US. A further test was performed for each group with the CS of the other group to see if the ants showed an odor generalization. The frequencies of MaLER-positive responses during tests were used as indication of learning performance. Ants learned the association between the CS and US during conditioning for both odors and showed initially significant and gradually decreasing MaLER-positive responses during tests. The results showed that conditioning to the odors was absolute and no generalization was observed. We conclude that associative learning is a universal strategy for ants to adjust their behaviors to environmental changes around them and the MaLER technique is a powerful and easy to apply technique to test learning and memory capacities in ants.
Burnout, mental health, physical symptoms, and coping behaviors in healthcare workers in Belize amidst COVID-19 pandemic: A nationwide cross-sectional study
Authors: Estephan Lila , Pu Christy , Bermudez Selma , Waits Alexander 
Published: February 2023

Background: Healthcare workers are vulnerable to burnout, especially during the COVID-19 pandemic in the low resource settings. Belize is a small Central American developing country known for its chronic healthcare worker shortage and this is the first study to assess burnout prevalence and its associated factors among healthcare workers in Belize. Aim: To evaluate the prevalence of burnout and its associated factors in HCWs in Belize covering multiple domains (mental health, physical symptoms, and coping behaviors) during the COVID-19 pandemic. Methods: A cross-sectional survey that was developed and validated by a panel of experts was delivered online to all the healthcare workers in Belize from September to November 2021. Burnout was assessed using Copenhagen Burnout Inventory. Depression and anxiety screening was carried out using the Patient Health Questionnaire – 2 (PHQ-2) and Generalized Anxiety Disorder 2-item (GAD-2). Burnout associated factors were estimated using logistic regression models. Findings: Of the total of 263 participants, 27.76% had overall burnout: 56.65% had personal, 54.37% had work-related, and 19.39% had patient-related burnout. Burnout was positively associated with anxiety (OR: 3.14 [1.67, 5.92]), depression (OR: 4.45 [2.30, 8.61]), intentions of quitting their jobs (OR: 2.59 [1.49, 4.51]), health status worsening (OR: 2.21 [1.26, 3.87]), multiple physical symptom presentation (OR: 1.19, [1.10, 1.29]), and use of multiple maladaptive coping behaviors (OR: 1.66, [1.30, 2.12]). Interpretation: Healthcare workers in Belize showed substantial levels of burnout which were significantly associated with using maladaptive coping behaviors, presenting multiple physical symptoms, quitting their jobs, health status worsening, and other mental health issues. These findings should be used to develop and implement programs such as regular health check-ups, health promotion awareness campaigns, and worker recruitment strategies which would improve the working conditions, quality of life, and psychological well-being of our healthcare workers.
Linear endovenous energy density (LEED) should always be quoted with the power used in endovenous thermal ablation – results from an in-vitro porcine liver model study
Authors: Nielsen Amanda G , Croucher Alexandra A , Muschamp Simon D , Losty Ethan , Worthington Thomas , Kiely Melissa J , Whiteley Mark S 
Published: February 2023

Background Linear Endovenous Energy Density (LEED) is the energy used per cm of vein in endovenous thermal ablation (EVTA) but does not include time. This study examines the effect of time during EVTA. Method EVTA was performed in a previously validated porcine liver model. LEEDs of 40, 60, 80 and 100 J/cm, using different powers were repeated 5 times each. Thermal spread, tissue carbonisation and device-tissue sticking during treatment were recorded. Result LEED positively correlated to thermal spread and carbonisation of the tissue. Power was correlated with carbonisation but not thermal spread. Pullback had no correlations with thermal spread or carbonisation. Catheter sticking found occurred in powers >= 15 W or LEED >= 80 J/cm. Conclusion LEED is a good measure of EVTA but does not include time. Power, which does include time, correlates with carbonisation and with device-tissue sticking. The power used must be quoted with the LEED.
Intermediate-weighted MRI with fat suppression (IW-FS): diagnostic performance for bone marrow edema and erosion detection in axial spondyloarthritis
Authors: Chen Min , Yu Keyan , Hu Xuehan , Jans Lennart , Qi Yulong , Liu Xin , Cheng Guanxun 
Published: February 2023

Background Bone marrow edema (BME) and erosion of the sacroiliac joint are both key lesions for diagnosing axial spondyloarthritis (axSpA) on magnetic resonance imaging (MRI). Purpose To qualitatively and quantitatively compare intermediate-weighted MRI with fat suppression (IW-FS) with T2-weighted short tau inversion recovery (T2-STIR) in assessment of sacroiliac BME and erosion in axSpA. Material and Methods Patients aged 18–60 years with axSpA were prospectively enrolled. All patients underwent a 3.0-T MRI examination of the sacroiliac joints. Para-coronal IW-FS, T2-STIR, and T1-weighted (T1W) images were acquired. BME and erosion were scored by two readers in consensus on IW-FS and STIR using a modified Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system. Consensus scores on T1WI were used as the reference for erosion. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured for BME. Results In total, 49 patients (mean age=33.4 ± 7.6 years) were included. More patients were scored as having BME on T2-STIR (36 vs. 29, P = 0.016). SPARCC-BME score on IW-FS was lower than that acquired on T2-STIR (mean, 11.5 vs. 14.7, P = 0.002). SNR and CNR of BME were both lower on IW-FS than on T2-STIR (mean SNR, 118 vs. 218, P < 0.001; mean CNR, 44 vs. 137, P < 0.001). The sensitivity of erosion detection was higher on IW-FS (83%) than on T2-STIR (54%, P = 0.006). Conclusion IW-FS is not sufficient for BME detection using T2-STIR as the reference standard in patients with axSpA. IW-FS has a much higher sensitivity than T2-STIR for erosion detection in the sacroiliac joint.