bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial forebrain domains
Authors: Bearer E. L. , Medina C. S. , Uselman T. W. , Jacobs R. E. 
Published: September 2023

AbstractNeurons project long axons that contact other distant neurons. Projections can be mapped by hijacking endogenous membrane trafficking machinery by introducing tracers. To witness functional connections in living animals, we developed a tracer detectible by magnetic resonance imaging (MRI), Mn(II). Mn(II) relies on kinesin-1 and amyloid-precursor protein to travel out axons. Within 24h, projection fields of cortical neurons can be mapped brain-wide with this technology. MnCl2was stereotactically injected either into anterior cingulate area (ACA) or into infralimbic/prelimbic (IL/PL) of medial forebrain (n=10-12). Projections were imaged, first bymanganese-enhancedMRI(MEMRI) live, and then after fixation by microscopy. MR images were collected at 100µm isotropic resolution (∼5 neurons) in 3D at four time points: before and at successive time points after injections. Images were preprocessed by masking non-brain tissue, followed by intensity scaling and spatial alignment. Actual injection locations, measured from post-injection MR images, were found to be 0.06, 0.49 and 0.84mm apart between cohorts, in R-L, A-P, and D-V directions respectively. Mn(II) enhancements arrived in hindbrains by 24h in both cohorts, while co-injected rhodamine dextran was not detectible beyond immediate subcortical projections. Data-driven unbiased voxel-wise statistical maps after ACA injections revealed significant progression of Mn(II) distally into deeper brain regions: globus pallidus, dorsal striatum, amygdala, hypothalamus, substantia nigra, dorsal raphe and locus coeruleus. Accumulation was quantified as a fraction of total volume of each segment containing significantly enhanced voxels (fractional accumulation volumes), and results visualized in column graphs. Unpaired t-tests between groups of brain-wide voxel-wise intensity profiling by either region of interest (ROI) measurements or statistical parametric mapping highlighted distinct differences in distal accumulation between injection sites, with ACA projecting to periaqueductal gray and IL/PL to basolateral amygdala (p<0.001 FDR). Mn(II) distal accumulations differed dramatically between injection groups in subdomains of the hypothalamus, with ACA targeting dorsal medial, periventricular region and mammillary body nuclei, while IL/PL went to anterior hypothalamic areas and lateral hypothalamic nuclei. Given that these hypothalamic subsegments communicate activity in the central nervous system to the body, these observations describing distinct forebrain projection fields will undoubtedly lead to newer insights in mind-body relationships.
Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer’s disease risk spectrum
Authors: Soch Joram , Richter Anni , Kizilirmak Jasmin M. , Schütze Hartmut , Altenstein Slawek , Dechent Peter , Fliessbach Klaus , Glanz Wenzel , Herrera Ana Lucia , Hetzer Stefan , Incesoy Enise I. , Kilimann Ingo , Kimmich Okka , Lammerding Dominik , Laske Christoph , Lohse Andrea , Lüsebrink Falk , Munk Matthias H. , Peters Oliver , Preis Lukas , Priller Josef , Rostamzadeh Ayda , Roy-Kluth Nina , Scheffler Klaus , Schneider Anja , Spottke Annika , Spruth Eike Jakob , Teipel Stefan , Wiltfang Jens , Jessen Frank , Düzel Emrah , Schott Björn H. 
Published: September 2023

AbstractIn functional magnetic resonance imaging (fMRI) studies, episodic memory is commonly investigated with the subsequent memory paradigm in which brain activity is recorded during encoding and analyzed as a function of subsequent remembering and forgetting. Impaired episodic memory is common in individuals with or at risk for Alzheimer’s disease (AD), but only few studies have reported subsequent memory effects in AD or its risk states like mild cognitive impairment (MCI). One reason for this might be that subsequent memory responses may be blunted in AD or MCI and thus less likely to manifest in fMRI signal differences. Here, we used Bayesian model selection of single-subject fMRI general linear models (GLMs) for a visual novelty and memory encoding experiment to compare the model performance of categorical and parametric subsequent memory models as well as memory-invariant models in a clinical cohort (N = 468) comprising healthy controls (HC) as well as individuals with subjective cognitive decline (SCD), MCI, and AD, plus healthy relatives of AD patients (AD-rel). We could replicate the previously reported superiority of parametric subsequent memory models over categorical models (Soch et al., 2021a) in the HC and also in the SCD and AD-rel groups. However, memory-invariant models outperformed any model assuming subsequent memory effects in the MCI and AD groups. In the AD group, we additionally found substantially lower model preference for models assuming novelty compared to models not differentiating between novel and familiar stimuli. Our results suggest that voxel-wise memory-related fMRI activity patterns in AD and also MCI should be interpreted with caution and point to the need for additional or alternative approaches to investigate memory function.
Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics
Authors: Qaqorh Tasneem , Takahashi Yusuke , Otani Kentaro , Yazawa Issei , Nishida Yuya , Fujihara Yoshitaka , Honda Mizuki , Oki Shinya , Ohkawa Yasuyuki , Thorburn David R. , Frazier Ann E. , Takeda Atsuhito , Ikeda Yoshihiko , Sakaguchi Heima , Watanabe Takuya , Fukushima Norihide , Tsukamoto Yasumasa , Makita Naomasa , Yamaguchi Osamu , Murayama Kei , Ohtake Akira , Okazaki Yasushi , Inoue Hijiri , Matsuoka Ken , Yamazaki Satoru , Takashima Seiji , Shintani Yasunori 
Published: September 2023

SummaryOxidative phosphorylation defects results in mitochondrial diseases, with cardiac involvement markedly impacting prognosis. However, the mechanisms underlying the transition from compensation to dysfunction in response to metabolic deficiency remain unclear, impeding the development of effective treatments. Here, we employed single-nucleus RNA sequencing (snRNA-seq) on hearts from mitochondrial cardiomyopathy (MCM) mice with cardiac-specificNdufs6knockdown (FS6KD). Pseudotime trajectory analysis of cardiomyocytes from early stage of female FS6KD hearts revealed dynamic cellular state transitioning from compensation to severe compromise, coincided with transient upregulation of a critical transcription factor,activating transcription factor 3(Atf3). Genetic ablation or adeno-associated virus-mediatedAtf3knockdown in FS6KD mice effectively delayed cardiomyopathy progression in a female-specific manner. Notably, human MCM snRNA-seq revealed a similar transition, including the dynamic expression ofATF3. In conclusion, our findings highlight a fate-determining role of Atf3 in female MCM progression, providing a promising therapeutic candidate for the currently intractable disease.
Modeling antecedents of safety compliance of construction workers in Australia: a perspective of trait activation theory
Authors: Yan Diya , Zhao Xianbo , Kalutara Pushpitha , Jiang Zhou 
Published: September 2023

PurposeConstruction workers’ safety compliance is attracting considerable critical attention as it plays a decisive role in improving safety on construction sites. This study applied the concept of differentiating safety compliance into deep compliance (DC) and surface compliance (SC) and relied on trait activation theory to investigate the effects of situational awareness (SA) and emotional intelligence (EI) on safety compliance.Design/methodology/approachCross-sectional survey data were collected from 239 construction workers in Australia, and these responses were statistically analyzed using the partial least squares structural equation modeling (PLS-SEM) to validate the proposed model.FindingsResults revealed that both EI and SA positively impacted DC and negatively impacted SC. Moreover, SA partially mediated the link between EI and two types of safety compliance (DC and SC). The outcomes showed that construction workers’ ability in regulating their emotions could influence their perception of environmental cues and the effectiveness of safety compliance behavior.Originality/valueThis study sheds light on investigating the antecedents of DC and SC from the perspective of trait activation theory. The findings also have practical implications, stating that construction site managers or safety professionals should consider providing training on construction workers’ EI and SA to enhance their willingness to expend conscious efforts in complying with safety rules and procedures, which can lead to improved safety outcomes.
Analysis of key brake pad parameters on brake system stability
Authors: Lin Dongdong , Yan Xiaoyu , Chen Binsan , She Na , Ding Yining , Dong Shichao 
Published: September 2023

Purpose
This study aims to explore the impact of key parameters of brake pads on the dynamic characteristics of the braking system.

Design/methodology/approach
This study conducted experimental research based on a friction testing machine with a slider-disc structure. The experiment studied the impact of key parameters of brake pads (rotation speed, pressure, mass, braking radius, etc.) and the braking environment (dry friction, wetness, sand, etc.) on the stability of the braking system. At the same time, a dynamic model of the brake pad braking system was established and compared with experimental results using the mathematical tool of autocorrelation coefficient.

Findings
The key parameters of brake pads have a significant impact on the dynamic characteristics of the braking system; under different conditions of brake pad mass, tribological parameters, brake pad radius and braking environment, the chaotic characteristics of the braking friction force signal show a trend of expansion or contraction, which can be suppressed by adjusting the key parameters of brake pads.

Originality/value
This study can provide a reference for optimizing the braking strategy and reducing noise and vibration in brake pad systems.
Fuzzy cost, revenue efficiency assessment and target setting in fuzzy DEA: a fuzzy directional distance function approach
Authors: Gerami Javad , Mozaffari Mohammad Reza , Wanke Peter , Tan Yong 
Published: September 2023

Purpose
This study aims to present the cost and revenue efficiency evaluation models in data envelopment analysis in the presence of fuzzy inputs, outputs and their prices that the prices are also fuzzy. This study applies the proposed approach in the energy sector of the oil industry.

Design/methodology/approach
This study proposes a value-based technology according to fuzzy input-cost and revenue-output data, and based on this technology, the authors propose an approach to calculate fuzzy cost and revenue efficiency based on a directional distance function approach. These papers incorporated a decision-maker’s (DM) a priori knowledge into the fuzzy cost (revenue) efficiency analysis.

Findings
This study shows that the proposed approach obtains the components of fuzzy numbers corresponding to fuzzy cost efficiency scores in the interval [0, 1] corresponding to each of the decision-making units (DMUs). The models presented in this paper satisfies the most important properties: translation invariance, translation invariance, handle with negative data. The proposed approach obtains the fuzzy efficient targets corresponding to each DMU.

Originality/value
In the proposed approach, by selecting the appropriate direction vector in the model, we can incorporate preference information of the DM in the process of evaluating fuzzy cost or revenue efficiency and this shows the efficiency of the method and the advantages of the proposed model in a fully fuzzy environment.
NPAs in India's banks: trends and determinants
Authors: Das Santosh Kumar 
Published: September 2023

PurposeThis paper aims to analyse trends and determinants of NPAs in India's banks. It has empirically examined the bank-specific determinants of NPAs.Design/methodology/approachAn FE panel estimation of a sample of 44 banks was carried out for the post-crisis time period, from 2010 to 2020 to identify the bank-specific determinants of NPAs. The sample of 44 banks includes 20 PSBs, 19 private banks and 5 foreign banks. Separate FE estimation was also carried out to identify the drivers of NPAs in PSBs.FindingsThe determinant of NPAs during the post-crisis period suggests that faulty earning management and deterioration in loan quality have resulted in high NPAs in India's banks. The result is similar for PSBs as well.Research limitations/implicationsThe findings of the study suggest that the banks, especially the Public Sector Banks (PSBs) need to revisit their earning management strategies to maximise income and improve their loan quality in order to reduce the incidence of loan failure.Originality/valueThe paper contributes by empirically analysing the determinants of NPAs during the recent decade, between 2010 and 2020. Separate estimations have been carried out to understand whether the drivers of NPAs differ in the case of PSBs.
The impact of knowledge brokering and role crafting on work engagement: a two-wave panel survey of older Japanese workers
Authors: Ishiyama Nobutaka 
Published: September 2023

PurposeThis study aimed to investigate the mechanisms of knowledge brokering and role crafting structures that promote the active engagement of older workers at work.Design/methodology/approachThe respondents were workers in Japan aged 55–64 years. A two-wave panel survey was conducted. The first and second survey waves included 1,527 and 1,467 respondents, respectively.FindingsThe results showed that knowledge brokering positively influenced work engagement directly and indirectly. In the three dimensions of role crafting, cognitive and task crafting had a positive effect on work engagement.Research limitations/implicationsThis study focused on older workers in Japan. Therefore, it is necessary to verify whether the same effect is observed in countries other than Japan or among younger workers.Practical implicationsOn an individual level, older workers should aim to keep acquiring new information inside and outside the organisation. On an organisational level, it is effective to increase opportunities for older workers to craft their work according to the socioemotional selectivity and selection optimisation and compensation theories.Originality/valueThis study reveals that knowledge brokering and cognitive crafting in role crafting have an important influence on the work engagement of older workers. Additionally, this study clarifies the impact of job crafting on older workers not only from the perspective of resource crafting to achieve person-job fit but also from the perspective of reframing perceptions through cognitive crafting in role crafting. These findings enable a clearer understanding of the relationship between role crafting and knowledge brokering, as well as the socioemotional selectivity and selection optimisation and compensation theories.
Trust in management and state government mitigate the relationships between individual- and state-level stressors and well-being during COVID-19
Authors: Henderson Alexandra A. , Jeong Sophia S. , Horan Kristin A. 
Published: September 2023

PurposeThis study aims to examine the role of trust in management and state government in mitigating the relationships between individual- and state-level stressors and well-being during the COVID-19 pandemic.Design/methodology/approachData were collected from a US sample still working during the first wave of infections (N = 437) and was supplemented with objective state-level data. Data were analyzed using hierarchical regression modeling with the PROC MIXED procedure with SAS software to incorporate both individual- and state-level variables.FindingsResults indicated that individual-level stressors (work and family role overload) were positively associated with stress; however, the relationship between family role overload and stress was mitigated among those with high trust in state government. Results indicated that state-level stressors (infection rates and population density) were not associated with stress; however, the relationship between state population density and stress was positive among those with low trust in management and negative among those with high trust in management.Practical implicationsThis study highlights the need for organization and government leaders to build trust before and during crisis situations, as well as engage in a collaborative approach to managing stressors in crisis situations.Originality/valueThis study highlights the importance of expanding the focus of employee trust across organizational boundaries for understanding employee well-being during a crisis situation. This study also demonstrates the cross-over effects of trust, such that organization leaders can protect workers from community stressors, while government leaders can protect workers from family stressors.
Sheltered or suppressed? Tree regeneration in unmanaged European forests
Authors: Käber Yannek , Bigler Christof , HilleRisLambers Janneke , Hobi Martina , Nagel Thomas A. , Aakala Tuomas , Blaschke Markus , Brang Peter , Brzeziecki Bogdan , Carrer Marco , Cateau Eugenie , Frank Georg , Fraver Shawn , Idoate‐Lacasia Jokin , Holik Jan , Kucbel Stanislav , Leyman Anja , Meyer Peter , Motta Renzo , Samonil Pavel , Seebach Lucia , Stillhard Jonas , Svoboda Miroslav , Szwagrzyk Jerzy , Vandekerkhove Kris , Vostarek Ondrej , Zlatanov Tzvetan , Bugmann Harald 
Published: September 2023

Abstract

Tree regeneration is a key demographic process influencing long‐term forest dynamics. It is driven by climate, disturbances, biotic factors and their interactions. Thus, predictions of tree regeneration are challenging due to complex feedbacks along the wide climatic gradients covered by most tree species. The stress gradient hypothesis (SGH) provides a framework for assessing such feedbacks across species ranges, suggesting that competition between trees is more frequent under favourable conditions, whereas reduced competition (i.e. positive interactions) is more likely under climatic stress. Moreover, tree life‐history strategies (LHS) may shed light on how and whether the SGH explains regeneration of different tree species.

To address these topics, we developed statistical models based on >50,000 recruitment events observed for 24 tree species in an extensive permanent plot network (6540 plots from 299 unmanaged European temperate, boreal and subalpine forests) covering a wide climatic gradient.

We found that the effects of Leaf Area Index (as a proxy for competition) on tree recruitment changed along climatic gradients but in a species‐specific manner. Competition predominates, with its intensity decreasing under stressful conditions for most species, as predicted by the SGH. However, positive interactions were only evident for a few species. Additionally, the ability of the SGH to explain patterns of competition and positive interactions across the gradients differed among species, with some differences and exceptions that may be related to varying LHS.

Synthesis. Our study shows that competition between trees toward climatic stress decreases systematically but depends on species stress tolerance to climate and shade. These findings explain within‐ and between‐species differences in tree recruitment patterns in European temperate forests. Moreover, our findings imply that projections of forest dynamics along wide climatic gradients and under climate change must accommodate both competition and positive interactions, as they strongly affect rates of community turnover.
An alternative model of maternity care for low‐risk birth: Maternal and neonatal outcomes utilizing the midwifery‐based birth center model
Authors: Wallace Jacqueline , Hoehn‐Velasco Lauren , Tilden Ellen , Dowd Bryan E. , Calvin Steve , Jolles Diana R. , Wright Jennifer , Stapleton Susan 
Published: September 2023

AbstractObjectiveTo assess key birth outcomes in an alternative maternity care model, midwifery‐based birth center care.Data SourcesThe American Association of Birth Centers Perinatal Data Registry and birth certificate files, using national data collected from 2009 to 2019.Study DesignThis observational cohort study compared key clinical birth outcomes of women at low risk for perinatal complications, comparing those who received care in the midwifery‐based birth center model versus hospital‐based usual care. Linear regression analysis was used to assess key clinical outcomes in the midwifery‐based group as compared with hospital‐based usual care. The hospital‐based group was selected using nearest neighbor matching, and the primary linear regressions were weighted using propensity score weights (PSWs). The key clinical outcomes considered were cesarean delivery, low birth weight, neonatal intensive care unit admission, breastfeeding, and neonatal death. We performed sensitivity analyses using inverse probability weights and entropy balancing weights. We also assessed the remaining role of omitted variable bias using a bounding methodology.Data CollectionWomen aged 16–45 with low‐risk pregnancies, defined as a singleton fetus and no record of hypertension or cesarean section, were included. The sample was selected for records that overlapped in each year and state. Counties were included if there were at least 50 midwifery‐based birth center births and 300 total births. After matching, the sample size of the birth center cohort was 85,842 and the hospital‐based cohort was 261,439.Principal FindingsWomen receiving midwifery‐based birth center care experienced lower rates of cesarean section (−12.2 percentage points, p < 0.001), low birth weight (−3.2 percentage points, p < 0.001), NICU admission (−5.5 percentage points, p < 0.001), neonatal death (−0.1 percentage points, p < 0.001), and higher rates of breastfeeding (9.3 percentage points, p < 0.001).ConclusionsThis analysis supports midwifery‐based birth center care as a high‐quality model that delivers optimal outcomes for low‐risk maternal/newborn dyads.
The relationship between dietary inflammatory index and bone mineral density in CKD patients
Authors: Wu Wenhui , Li Xiurong , Di Jia , Zhou Hua , Niu Hongyan , Chen Lu , Sha Qi , Yang Min 
Published: September 2023

AbstractIntroductionChronic systemic inflammation was proposed as a critical factor in the development of osteoporosis. We aim to investigate the effect of the DII on bone mineral density (BMD) in CKD patients.Methods2276 participants from NHANES were enrolled. The DII score was calculated based on a single 24‐h dietary recall. Total BMD was measured using Dual‐energy x‐ray absorptiometry. A multiple‐stepwise linear regression model was used to determine associations between BMD and DII in CKD patients.ResultsWhen DII >0.35, a negative correlation was obtained between DII and BMD (all β = −0.008 and p < 0.05). In subgroup analysis, BMD levels decreased across increasing tertiles of the DII for patients with non‐osteoporosis, postmenopause, and low eGFR (p for trend ≤0.01).ConclusionHigher consumption of pro‐inflammatory diet correlates negatively with the BMD levels in CKD patients.