bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bâtir une GRH inclusive en PME au travers des relations de don/contre-don entre dirigeant et salariés
Authors: Adla Ludivine , Gallego-Roquelaure Virginie 
Published: July 2023

Évoluant dans des contextes économique et géopolitique turbulents, des questions sociales s’ajoutent aux difficultés quotidiennes des PME. Certains dirigeants sont donc amenés à concilier leurs différentes préoccupations, tout en replaçant les salariés au coeur de l’organisation. Autrement dit, il s’agit de mieux prendre en compte leurs attentes et de les faire participer aux décisions relatives à la gestion des ressources humaines. Dans cette optique, l’émergence d’une GRH inclusive, favorisant l’épanouissement professionnel et la reconnaissance de chaque salarié, s’invite en PME.
Ainsi, notre étude exploratoire apporte des éléments de réponse à sa construction, tout en remettant en question certaines croyances établies. En effet, à travers la logique du don, nous montrons que cette GRH repose principalement sur des relations d’échange, qui ne sont pas exemptes de difficultés.

Résumé

Cet article vise à comprendre l’émergence et le développement d’une gestion des ressources humaines (GRH) inclusive en PME. Le concept d’inclusion renvoie à l’épanouissement professionnel et à la reconnaissance des salariés (Bonneveux et al., 2020). Cette forme de GRH comporte une visée intégrative dans la mesure où elle offre la possibilité d’améliorer la collaboration notamment entre le dirigeant et ses salariés. Dans cette optique, nous avons mobilisé de façon originale la logique du don de Mauss, couplée à la littérature sur la GRH en PME afin de proposer une nouvelle grille de lecture. À partir du cas emblématique d’une PME, une étude qualitative longitudinale a été menée sur une période de 8 ans.
Les résultats soulignent le décalage entre les contre-dons attendus et ceux réellement réalisés par le dirigeant, qui conditionnent in fine l’adonnement des salariés. Ce déséquilibre dans la relation amène à la construction d’une GRH inclusive.
Reproductive Parameters and Oxidative Stress Marker Impacts Associated with Oral and Inhalation Exposure to Chlorview
Authors: U. Amadi Eustace , J. Nweze Ekene , U. Amalunweze Adaude , S. Ubani Chibuike 
Published: July 2023

Aim: Factory workers, pesticide applicators and farmers are the most susceptible group to reproductive problems due to continuous exposure to pesticides. Farmers now increasingly deploy pesticides in their agronomic practices. This research aimed to assess the impact on reproductive markers and stress markers of acute exposure to chlorview, an organophosphate pesticide, through oral and inhalation routes using animal model.
Study Design: A total of 64 male wistar rats were used for the experiment. The animals were divided into two groups for oral (36 rats) and inhalation (28 rats) routes of exposure. Acute toxicity studies and the median lethal dose were carried out using a modified method.
Methodology: Standard methods were used to determine oxidative stress markers of lipid peroxides, catalase activity and glutathione peroxidase activity. Immunoassay test kit was used to determine the reproductive toxicity studies.
Results: The results from the 24 hour acute toxicity studies revealed that oral exposure to pesticide gave a median lethal dose (LD50) of 155 mg/kg b.w. while inhalation exposure gave a median lethal concentration (LC50) of 1414 mg/kg b.w. for 60 min. Oxidative stress markers [glutathione (GSH), Malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx)] show that the pesticide induced appreciable oxidative imbalance in the system. In oral exposure, there was a significant (p<0.05) increase in the activity when compared to control. The reproductive marker toxicity studies revealed that oral exposure to pesticide led to a significant (p<0.05) increase in the Cholesterol (which has a correlation with estradiol) and a significantly (p<0.05) decreased in testosterone and sperm count when compared to control. This research concludes that exposure to pesticides can pose a reasonable risk to reproductive and stress markers through oral and inhalation routes of exposure which affect many biochemical processes.
Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis
Authors: Blackman Graham , Neri Giulia , Al-Doori Omar , Teixeira-Dias Maria , Mazumder Asif , Pollak Thomas A. , Hird Emily J. , Koutsouleris Nikolaos , Bell Vaughan , Kempton Matthew J. , McGuire Philip 
Published: July 2023

ImportanceIndividuals presenting with first-episode psychosis (FEP) may have a secondary (“organic”) etiology to their symptoms that can be identified using neuroimaging. Because failure to detect such cases at an early stage can have serious clinical consequences, it has been suggested that brain magnetic resonance imaging (MRI) should be mandatory for all patients presenting with FEP. However, this remains a controversial issue, partly because the prevalence of clinically relevant MRI abnormalities in this group is unclear.ObjectiveTo derive a meta-analytic estimate of the prevalence of clinically relevant neuroradiological abnormalities in FEP.Data SourcesElectronic databases Ovid, MEDLINE, PubMed, Embase, PsychINFO, and Global Health were searched up to July 2021. References and citations of included articles and review articles were also searched.Study SelectionMagnetic resonance imaging studies of patients with FEP were included if they reported the frequency of intracranial radiological abnormalities.Data Extraction and SynthesisIndependent extraction was undertaken by 3 researchers and a random-effects meta-analysis of pooled proportions was calculated. Moderators were tested using subgroup and meta-regression analyses. Heterogeneity was evaluated using the I2 index. The robustness of results was evaluated using sensitivity analyses. Publication bias was assessed using funnel plots and Egger tests.Main Outcomes and MeasuresProportion of patients with a clinically relevant radiological abnormality (defined as a change in clinical management or diagnosis); number of patients needed to scan to detect 1 such abnormality (number needed to assess [NNA]).ResultsTwelve independent studies (13 samples) comprising 1613 patients with FEP were included. Of these patients, 26.4% (95% CI, 16.3%-37.9%; NNA of 4) had an intracranial radiological abnormality, and 5.9% (95% CI, 3.2%-9.0%) had a clinically relevant abnormality, yielding an NNA of 18. There were high degrees of heterogeneity among the studies for these outcomes, 95% to 73%, respectively. The most common type of clinically relevant finding was white matter abnormalities, with a prevalence of 0.9% (95% CI, 0%-2.8%), followed by cysts, with a prevalence of 0.5% (95% CI, 0%-1.4%).Conclusions and RelevanceThis systematic review and meta-analysis found that 5.9% of patients presenting with a first episode of psychosis had a clinically relevant finding on MRI. Because the consequences of not detecting these abnormalities can be serious, these findings support the use of MRI as part of the initial clinical assessment of all patients with FEP.
Embedded Bioprinting of Breast Tumor Cells and Organoids Using Low‐Concentration Collagen‐Based Bioinks
Authors: Shi Wen , Mirza Sameer , Kuss Mitchell , Liu Bo , Hartin Andrew , Wan Shibiao , Kong Yunfan , Mohapatra Bhopal , Krishnan Mena , Band Hamid , Band Vimla , Duan Bin 
Published: July 2023

AbstractBioinks for 3D bioprinting of tumor models should not only meet printability requirements but also accurately maintain and support phenotypes of tumor surrounding cells to recapitulate key tumor hallmarks. Collagen is a major extracellular matrix protein for solid tumors, but low viscosity of collagen solution has made 3D bioprinted cancer models challenging. This work produces embedded, bioprinted breast cancer cells and tumor organoid models using low‐concentration collagen I based bioinks. The biocompatible and physically crosslinked silk fibroin hydrogel is used to generate the support bath for the embedded 3D printing. The composition of the collagen I based bioink is optimized with a thermoresponsive hyaluronic acid‐based polymer to maintain the phenotypes of both the noninvasive epithelial and invasive breast cancer cells, as well as cancer‐associated fibroblasts. Mouse breast tumor organoids are bioprinted using optimized collagen bioink to mimic in vivo tumor morphology. A vascularized tumor model is also created using a similar strategy, with significantly enhanced vasculature formation under hypoxia. This study shows the great potential of embedded bioprinted breast tumor models utilizing a low‐concentration collagen‐based bioink for advancing the understanding of tumor cell biology and facilitating drug discovery research.
Aliphatic Alcohol Hydroxyl‐Directed One‐Pot Stepwise Synthesis: A Concise Synthesis of 1H‐pyrrolo[3,4‐b]quinoline‐1,3(2H)‐diones
Authors: Huang Shuntao , Yang Qi , Wan Juan , Wang Zhuoyu , Zhang Zhou , Liu Teng , Huang Chao 
Published: July 2023

AbstractA concise and flexible protocol to assemble structurally diverse 1H‐pyrrolo[3,4‐b]quinoline‐1,3(2H)‐diones (29 examples, 70–87% yields) has been developed via one‐pot stepwise synthesis. The potentially valuable quinine‐fused heterocycles were synthetized by utilizing aliphatic alcohol hydroxyl as directing group which promoted a sequential transformation to form functionalized aminomaleimides, and then underwent an I2‐oxidized tandem annulations. This route involved the formation of multiple new chemical bonds (C=N, 2C−N, C−C) in a one‐pot fashion under mild conditions.
Synthesis of Tetraazamacrocycles by Sequential Palladium‐Catalyzed Allylic Substitution Reactions
Authors: Lee Seoyoung , Kim Juyeong , Kang Kyungjun , Lee Ansoo , Kim Hyunwoo 
Published: July 2023

AbstractIn this study, we focused on the synthesis of tetraazamacrocycles, an essential class of macrocyclic compounds with applications in coordination chemistry, pharmaceuticals, and catalysis. To accomplish this, we developed a ligand‐controlled palladium‐catalyzed allylic substitution approach using bicyclic bridgehead phosphoramidite (briphos) ligands. This approach allowed us to selectively achieve [1+1] and [1+2] allylic aminations between allylic diols and diamines, while avoiding the formation of cyclic [1+1] products. By combining this approach with sequential acetylation and allylic amination, we successfully synthesized tetraazamacrocycles with ring sizes ranging from 16 to 38. These findings demonstrate the potential of a sequential allylation strategy for synthesizing complex molecules with broad applications in the fields of chemistry, pharmaceuticals, and medicine.
Copper‐Catalyzed Olefinic C(sp2)−H Activation/Carbene Insertion/Ester Hydrolysis/Cyclization with Aryl Diazo Esters for the Synthesis of Multisubstituted Furanones
Authors: Wang Yuzhi , Yu Yadong , Yu Yang , Huang Fei , Baell Jonathan B. 
Published: July 2023

AbstractA copper‐catalyzed olefinic C(sp2)−H activation/carbene insertion/ester hydrolysis/cyclization sequence has been developed for the synthesis of substituted 2(5H)‐furanones employing readily available enaminones and aryl diazo esters as substrates. This method features operationally simple and good functional group tolerance. The transformation could be scaled up to gram quantities and the obtained 2(5H)‐furanone derivatives could be easily converted to a wide range of useful synthetic building blocks, indicative of the applicability of the synthetic strategy. Isotope labeling experiments demonstrated the ester group of diazo esters was hydrolyzed during the reaction.
Palladium‐Catalyzed Chemoselective Mono‐α‐Arylation of O‐Protected Hydroxyacetone with Ortho‐Substituted (Hetero)aryl Electrophiles
Authors: MacMillan Joshua W. M. , Lundrigan Travis , Volpin Giulio , Kaldas Sherif J. , Holstein Philipp M. , Ford Mark James , Guimond Nicolas , Stradiotto Mark 
Published: July 2023

AbstractThe mono‐α‐arylation of 2‐tetrahydropyranyl O‐protection of hydroxyacetone is reported. When using a catalyst system comprised of [Pd(cinnamyl)Cl]2 and the JosiPhos ligands PhPF‐tBu or (4‐CF3Ph)PF‐tBu, such transformations are achieved with ortho‐substituted aryl bromides and triflates in the presence of potentially contending functionalities including chloro groups.
15q26.3 deletions distal to IGF1R cause growth retardation, congenital heart defect and skeletal anomalies: Case report and review of literature
Authors: Sivakumaran Theru A. , Grebe Theresa A. 
Published: July 2023

Abstract15q26 deletion is a rare genomic disorder characterized by intrauterine and postnatal growth retardation, microcephaly, intellectual disability, and congenital malformations. Here, we report a 4‐month‐old female with intrauterine growth retardation, short stature, pulmonary hypertension, atrial septal defect and congenital bowing of long bones of the legs. Chromosomal microarray analysis showed a de novo deletion of approximately 2.1 Mb at 15q26.3 region that does not include IGF1R. Our analysis of patients documented in the literature and the DECIPHER database with 15q26 deletions distal to IGF1R, including 10 patients with de novo pure deletions, allowed us to define the smallest region of overlap to 686 kb. This region includes ALDH1A3, LRRK1, CHSY1, SELENOS, SNRPA1, and PCSK6. We propose haploinsufficiency of one or more genes, besides IGF1R, within this region may contribute to the clinical findings in patients with 15q26.3 deletion.
The national public health response to Alzheimer's disease and related dementias: Origins, evolution, and recommendations to improve early detection
Authors: Vinze Sanjna , Chodosh Joshua , Lee Matthew , Wright Jacob , Borson Soo 
Published: July 2023

AbstractLongstanding gaps in the detection of Alzheimer's disease and related dementias (ADRD) and biopsychosocial care call for public health action to improve population health. We aim to broaden the understanding of the iterative role state plans have played over the last 20 years in prioritizing improvements in the detection of ADRD, primary care capacity, and equity for disproportionately affected populations. Informed by national ADRD priorities, state plans convene stakeholders to identify local needs, gaps, and barriers and set the stage for development of a national public health infrastructure that can align clinical practice reform with population health goals. We propose policy and practice actions that would accelerate the collaboration between public health, community organizations, and health systems to improve ADRD detection—the point of entry into care pathways that could ultimately improve outcomes on a national scale.HIGHLIGHTS
We systematically reviewed the evolution of state/territory plans for Alzheimer's disease and related dementias (ADRD).
Plan goals improved over time but lacked implementation capacity.
Landmark federal legislation (2018) enabled funding for action and accountability.
The Centers for Disease Control and Prevention (CDC) funds three Public Health Centers of Excellence and many local initiatives.
Four new policy steps would promote sustainable ADRD population health improvement.
Kyoto Collection in The Anatomical Record
Authors: Yamada Shigehito 
Published: July 2023

AbstractHuman embryology began at the end of the 19th century and has developed using valuable human embryo specimens; the Carnegie and Blechshmidt Collections are famous examples. Although established after these two collections, the Kyoto Collection of Human Embryos and Fetuses has become the largest collection worldwide, and its major asset is 1044 serial tissue sections comprising 547 normal and 497 abnormal cases. Morphological changes have been the focus of analysis owing to the absence of fresh embryos in the Kyoto Collection. Furthermore, analysis methods have undergone significant changes. For example, morphometrics has been used to quantitatively analyze shape changes, although it may result in the loss of information on shape changes, which can hinder the visualization of analysis results. However, geometric morphometrics has been recently introduced to the fetal and embryonic stages to circumvent this problem. With the development of DNA analysis kits, several hundred DNA base pairs have been extracted from the Kyoto Collection of studies conducted from the 2000s to the 2010s through genetic analysis. Future technological advances are eagerly awaited.
Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Authors: Kurt‐Celep İnci , Zengin Gokhan , Uba Abdullahi I. , Caprioli Giovanni , Mustafa Ahmed M. , Angeloni Simone , Cakilcioglu Ugur , Guler Osman , Kaplan Alevcan , Sharmeen Jugreet , Mahomoodally Mohamad F. 
Published: July 2023

AbstractSix extracts (water, ethanol, ethanol‐water, ethyl acetate, dichloromethane, and n‐hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high‐performance liquid chromatography‐mass spectrometry (HPLC‐MS), the ethanol‐water extract yielded the highest total bioactive content (4242.90 µg g−1), followed by the ethanol and water extracts (3721.24 and 3661.37 µg g−1, respectively), while the least total bioactive content was yielded by the hexane extract, followed by the dichloromethane and ethyl acetate extracts (47.44, 274.68, and 688.89 µg g−1, respectively). Rutin, p‐coumaric, chlorogenic, isoquercitrin, and delphindin‐3,5‐diglucoside were among the major components. Unlike the dichloromethane extracts, all the other extracts showed radical scavenging ability in the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assay (8.73–52.11 mg Trolox equivalent [TE]/g), while all extracts displayed scavenging property in the 2,2‐azino‐bis(3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS) radical scavenging assay (16.18–282.74 mg TE/g). The extracts showed antiacetylcholinesterase (1.27–2.73 mg galantamine equivalent [GALAE]/g), antibutyrylcholinesterase (0.20–5.57 mg GALAE/g) and antityrosinase (9.37–63.56 mg kojic acid equivalent [KAE]/g) effects. The molecular mechanism of the H2O2‐induced oxidative stress pathway was aimed to be elucidated by applying ethanol, ethanol/water and water extracts at 200 µg/mL concentration to human dermal cells (HDFs). A. caraganae in HDF cells had neither a cytotoxic nor genotoxic effect but could have a cytostatic effect in increasing concentrations. The findings have allowed a better insight into the pharmacological potential of the plant, with respect to their chemical entities and bioactive contents, as well as extraction solvents and their polarity.
Identifying new small proteins through a molecular biology course‐based undergraduate research experience laboratory class
Authors: Miranda Rommel J. , Warren Cheryl , Mcdougal Kathryn , Kimble Steven , Sanchez Joseph , Norman Leann , Anderson Virginia , Hemm Matthew 
Published: July 2023

AbstractWe developed a curriculum for an upper‐level molecular biology course‐based undergraduate research laboratory class funded by a National Science Foundation CAREER grant that focuses on identifying new small proteins in the bacterium, Escherichia coli. Our CURE class has been continually offered each semester for the last 10 years, with multiple instructors collaboratively developing and implementing their own pedagogical approach while maintaining the same overall scientific goal and experimental strategy. In this paper, we delineate the experimental strategy for our molecular biology CURE laboratory class, describe a range of pedagogical approaches implemented by multiple instructors, and provide recommendations for teaching the class. The purpose of our paper is to share our experiences both in developing and teaching a molecular biology CURE laboratory class based on small protein identification and in creating a curriculum and support system that allows traditional, non‐traditional, and under‐represented students to participate in authentic research projects.
Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors
Authors: Wu Yingwen , Zoller Ben G. E. , Kamal Mohamed Ashraf Mostafa , Hotop Sven‐Kevin , Lehr Claus‐Michael , Brönstrup Mark , Dersch Petra , Empting Martin 
Published: July 2023

AbstractPolymicrobial infections involving various combinations of microorganisms, such as Escherichia, Pseudomonas, or Yersinia, can lead to acute and chronic diseases in for example the gastrointestinal and respiratory tracts. Our aim is to modulate microbial communities by targeting the posttranscriptional regulator system called carbon storage regulator A (CsrA) (or also repressor of secondary metabolites (RsmA)). In previous studies, we identified easily accessible CsrA binding scaffolds and macrocyclic CsrA binding peptides through biophysical screening and phage display technology. However, due to the lack of an appropriate in bacterio assay to evaluate the cellular effects of these inhibitor hits, the focus of the present study is to establish an in bacterio assay capable of probing and quantifying the impact on CsrA‐regulated cellular mechanisms. We have successfully developed an assay based on a luciferase reporter gene assay, which in combination with a qPCR expression gene assay, allows for the monitoring of expression levels of different downstream targets of CsrA. The chaperone protein CesT was used as a suitable positive control for the assay, and in time‐dependent experiments, we observed a CesT‐mediated increase in bioluminescence over time. By this means, the cellular on‐target effects of non‐bactericidal/non‐bacteriostatic virulence modulating compounds targeting CsrA/RsmA can be evaluated.
Possible role of translation in unfertilized sea urchin eggs
Authors: Yakovlev Konstantin V. 
Published: July 2023

AbstractUnfertilized eggs of animals contain maternal messenger RNAs (mRNAs) and proteins, which are required for the maintenance of metabolism and regulation of development during the initial stages of embryogenesis. Unfertilized eggs are transcriptionally and translationally quiescent. After fertilization, activated translation of maternal mRNAs is one of the major forces that direct the early stages of embryogenesis before activation of the zygotic genome. However, a low rate and level of protein synthesis have been detected in unfertilized sea urchin eggs indicating that translation is not completely inhibited. Analysis of translatomes of unfertilized eggs and early embryos detected three sets of maternal mRNAs translated either before or after fertilization, or both before and after fertilization. Proteins encoded by maternal mRNAs, which are translated in unfertilized eggs, perform many different functions required for homeostasis, fertilization, egg activation, and early development. This suggests that translation in unfertilized sea urchin eggs may be required to renew the pool of proteins involved in these processes. Thus, translation may be necessary to maintain the fertility and developmental potential of sea urchin eggs during the long‐term storage of eggs in ovaries until spawning begins.