bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonal mast cell disorders and hereditary α‐tryptasemia as risk factors for anaphylaxis
Authors: Kačar Mark , Rijavec Matija , Šelb Julij , Korošec Peter 
Published: January 2023

AbstractThe association between Hymenoptera venom‐triggered anaphylaxis (HVA) and clonal mast cell‐related disorders (cMCD) has been known for decades. However, recent breakthroughs in peripheral blood screening for KIT p.D816V missense variant have revealed the true extent of this clinical association whilst adding to our understanding of the underlying aetiology. Thus, recent large studies highlighted the presence of KIT p.D816V among 18.2% and 23% of patients with severe Hymenoptera venom‐triggered anaphylaxis. A significant proportion of those patients have normal serum basal tryptase (BST) levels, with no cutaneous findings such as urticaria pigmentosa or other systemic findings such as organomegaly that would have suggested the presence of cMCD. These findings of an increased prevalence suggest that the impact of cMCD on anaphylaxis could be clinically underestimated and that the leading question for clinicians could be changed from ‘how many patients with cMCD have anaphylaxis?’ to ‘how many patients with anaphylaxis have cMCD?’. The discovery of hereditary α‐tryptasemia (HαT)—a genetic trait caused by an increased copy number of the Tryptase Alpha/Beta 1 (TPSAB1) gene‐, first described in 2016, is now known to underlie the majority of cases of elevated BST outside of cMCD and chronic kidney disease. HαT is the first common heritable genetic modifier of anaphylaxis described, and it is associated with increased risk for severe HVA (relative risk = 2.0), idiopathic anaphylaxis, and an increased prevalence of anaphylaxis in patients with cMCD, possibly due to the unique activity profile of α/β ‐tryptase heterotetramers that may potentiate immediate hypersensitivity reaction severity. Our narrative review aims to highlight recent research to have increased our understanding of cMCD and HαT, through recent lessons learned from studying their association with HVA. Additionally, we examined the studies of mast cell‐related disorders in food and drug allergy in an effort to determine whether one should also consider cMCD and/or HαT in cases of severe anaphylaxis triggered by food or drugs.
Customized 3D‐printed molds for high dose‐rate brachytherapy in facial skin cancer: First clinical experience
Authors: Chatzikonstantinou Georgios , Diefenhardt Markus , Fleischmann Maximilian , Meissner Markus , Scherf Christian , Trommel Martin , Ramm Ulla , Rödel Claus , Tselis Nikolaos , Licher Jörg 
Published: January 2023

SummaryBackground and ObjectiveRadiotherapy of elderly, frail patients with facial skin cancer in proximity to critical organs is challenging. This is the first report on clinical experience with facial skin cancer treated by individualized 3D‐printer‐based mold high‐dose‐rate (HDR) brachytherapy (BT).Patients and MethodsFifteen patients not eligible for radical surgery or definitive external beam radiotherapy (EBRT) were treated with 3D‐printer‐based mold HDR‐BT. Patient selection and treatment were in accordance with multidisciplinary tumor board recommendations. Clinical response, toxicity and cosmesis were analyzed.ResultsMedian age was 77 years. Histology revealed squamous cell carcinoma in seven, basal cell carcinoma in five, melanoma in situ in one, Lentigo maligna in one, and melanoma in one patient, respectively. Median prescription dose was 39 Gy delivered in once‐daily fractions of 3 Gy. After a median follow‐up of 12.2 months, local recurrence was observed in one patient with melanoma in situ. Apart from one grade 4 cataract, no other > grade 2 late toxicity was documented.ConclusionsHDR‐BT with 3D‐printer‐based molds for facial skin cancer is a well‐tolerated and safe treatment option for elderly, frail patients not eligible for radical surgery or definitive EBRT due to functional inoperability or tumor location.
Cancer and the entangled creator: Deep incarnation and the analeptic cross
Authors: Simmons Ernest Lee 
Published: January 2023

AbstractThe metaphorical appropriation of quantum entanglement (non‐local relational holism) helps to conceptualize the physical relationship of God to creation in a way which can support the understanding of deep incarnation. The relational holism of Divine entanglement helps clarify how deep incarnation is possible. Deep incarnation in turn assists with the understanding of God's connectivity and ongoing relationality to a suffering world, bringing hope and love in the midst of the pain and loss of evolutionary biology gone awry, including in cancer. The Logos of creation is also a suffering Logos, a Logos Pathos, that makes hope possible at such times and gives rise to what may be referred to as an Analeptic Cross, the cross embracing and “taking up” all of evolutionary suffering from the beginning. The Analeptic Cross is a way of revealing or making manifest the Logos Pathos. The article concludes with the role of faith in grounding hope in the midst of loss, providing resilience and courage in the midst of uncertainty. Deep incarnation means that God is with us even in the midst of malignancy.
A step‐by step guide for autotransplantation of teeth
Authors: Tsukiboshi Mitsuhiro , Tsukiboshi Chie , Levin Liran 
Published: January 2023

AbstractTooth loss is an adverse consequence of oral diseases and traumatic dental injuries. Although several treatment options exist to treat a missing or hopeless tooth, especially in young individuals, most of the existing alternatives (such as orthodontic treatment, removable or fixed partial dentures, and dental implants) impose a challenge in children due to the nature of the developing jaw bones. Tooth autotransplantation is the replacement of a tooth with another functional tooth within the patient's dentition. Autotransplantation can serve as a promising treatment alternative in cases of tooth loss not only in children and adolescents but also in adult patients. Autotransplantation is a technique‐sensitive procedure, that requires proper and thorough planning as well as careful and knowledgeable execution in order to improve the chances for long‐term success and survival of the transplanted tooth. Thus, the aim of this article was to provide a step‐by‐step clinical guide, emphasizing key points and highlights for planning and performing a successful autotransplantation procedure. Autotransplantation is a very predictable treatment modality that can serve as a viable option to replace a missing tooth, especially in young patients. Proper planning and careful execution of the procedure are important to achieve optimal long‐term results.
Effects of ejaculate size on remating, attractiveness, and oviposition in females of the sweetpotato weevil, Cylas formicarius
Authors: Hiroyoshi S. , Mitsunaga T. , Kohama T. , Reddy G. V. P. 
Published: January 2023

AbstractIn many insect species, female remating is triggered by the reduction in male ejaculates stored by females, including sperm and/or seminal fluids transferred during mating. Although females of the sweetpotato weevil, Cylas formicarius (Fabricius) (Coleoptera: Brentidae) are not monogamous, they are slow to remate. We investigated whether male age and mating history, which affect ejaculate size, influence female reproduction in this weevil. We prepared two female groups with different ejaculate sizes (small or large). Females that mated with young (10‐day‐old) virgin males with small ejaculates remated earlier than those that mated with older (30‐ or 50‐day‐old) virgin males with large ejaculates. The 6‐day fecundity did not differ between females that attracted males and those that did not, suggesting that most females with less ejaculate can lay eggs. Given that the number of sperm in the spermathecae of females that attracted males was smaller than that in females that did not attract males, we hypothesize that less ejaculate might enhance a female's attractiveness to males. Interestingly, 20% of females that laid no eggs on the last day observed (day 6) contained >1000 sperm in the spermatheca suggesting that sperm depletion alone did not suppress oviposition behavior. In conclusion, females of this weevil that had received small ejaculates were likely to be attractive to males, resulting in female remating, but cessation of oviposition is not due to sperm depletion alone; instead, it is likely a response to a decrease in the level of seminal fluids.
Autistic features and executive functions in first episode psychosis: Associations with functionality and quality of life
Authors: Davut Genç , Onur Durmaz , Hüseyin Güleç 
Published: January 2023

AbstractAimThe present study aimed at investigating the relationships between autistic features and cognitive deficits, functionality and quality of life in first episode psychosis (FEP) patients.MethodsSixty FEP patients [mean age (SD) = 32.53 (10.74), n = 23 female, n = 37 male] were enrolled in this cross‐sectional study. Data was collected using a sociodemographic and clinical data form, the Positive and Negative Syndrome Scale (PANSS), the PANSS Autism Severity Score (PAUSS), the Personal and Social Performance Scale (PSP), the Frontal Assessment Battery (FAB), and the World Health Organization Quality of Life Scale Short Form in Turkish Version (WHOQOL‐BREF TR).ResultsAutistic symptom severity was found to be higher in males than females, and higher in patients with a family history of psychotic disorder. An inverse relationship was found between the duration of education and the severity of autistic symptoms. While there was an inverse relationship between autistic symptom severity and executive functions and functionality, no significant correlation was found with quality of life. Negative symptom severity was a predictor of executive functions and functionality. No significant difference was observed between autistic and psychotic domains which were related to executive functions.ConclusionsOur study is the first to examine the relationship between autistic/psychotic symptoms and executive functions and functionality in patients with FEP. The results show that autistic symptoms are associated with worse social and personal functioning and worse executive functions in patients with FEP. Longitudinal follow‐up studies with larger samples are required to determine the direction of the relations.
Global reported impacts of COVID‐19 on lymphoma patients and the emerging clinical management approaches in response to the ongoing pandemic
Authors: Elliott Esther K. , Hensen Robert , Haupt Larisa M. , Griffiths Lyn R. 
Published: January 2023

AbstractThe Coronavirus disease 2019 (COVID‐19) pandemic has dramatically impacted the health risk and management of patients with lymphoma. Clinical evaluations on the impact of COVID‐19 on lymphoma patients are currently limited however, reports have shown a correlation with specific variants and more severe COVID‐19 complications and higher mortality rates relative to other disease states and age‐matched populations. During peak pandemic periods this created a concerning management problem for clinicians and raised the question of how different immunocompromised states increase COVID‐19‐associated risk and provided insights into how immunity interacts with the circulating variant, including the effects of low virulent variants in vaccinated lymphoma populations. Treatment management approaches, polymerase chain reaction tests and rapid antigen screening guidelines have been offered in an attempt to reduce the risk of harm to lymphoma patients, particularly prior to and following bone marrow or stem cell transplant. Here we systematically review the current literature to provide a novel global perspective on incidence, mortality, management and rapid antigen test (RAT) screening for COVID‐19, in patients with various subtypes of lymphoma. Furthermore, lessons learned from emerging variants that continue to inform evolving lymphoma management and public health policies are addressed across these associated matters.
Associations between testing and treatment pathways in lesional temporal or extratemporal epilepsy: A census survey of NAEC center directors
Authors: Beatty Christopher W. , Ahrens Stephanie M. , Arredondo Kristen H. , Bagić Anto I. , Bai Shasha , Chapman Kevin E. , Ciliberto Michael A. , Clarke Dave F. , Eisner Mariah , Fountain Nathan B. , Gavvala Jay R. , Perry M. S. , Rossi Kyle C. , Wong‐Kisiel Lily C. , Herman Susan T. , Ostendorf Adam P. ,   the NAEC Center Director Study Group
Published: January 2023

AbstractObjectiveThe evaluation to determine candidacy and treatment for epilepsy surgery in persons with drug‐resistant epilepsy (DRE) is not uniform. Many non‐invasive and invasive tests are available to ascertain an appropriate treatment strategy. This study examines expert response to clinical vignettes of magnetic resonance imaging (MRI)–positive lesional focal cortical dysplasia in both temporal and extratemporal epilepsy to identify associations in evaluations and treatment choice.MethodsWe analyzed annual report data and a supplemental epilepsy practice survey reported in 2020 from 206 adult and 136 pediatric epilepsy center directors in the United States. Non‐invasive and invasive testing and surgical treatment strategies were compiled for the two scenarios. We used chi‐square tests to compare testing utilization between the two scenarios. Multivariable logistic regression modeling was performed to assess associations between variables.ResultsThe supplemental survey response rate was 100% with 342 responses included in the analyses. Differing testing and treatment approaches were noted between the temporal and extratemporal scenarios such as chronic invasive monitoring selected in 60% of the temporal scenario versus 93% of the extratemporal scenario. Open resection was the most common treatment choice; however, overall treatment choices varied significantly (p < .001). Associations between non‐invasive testing, invasive testing, and treatment choices were present in both scenarios. For example, in the temporal scenario stereo‐electroencephalography (SEEG) was more commonly associated with fluorodeoxyglucose–positron emission tomography (FDG‐PET) (odds ratio [OR] 1.85; 95% confidence interval [CI] 1.06–3.29; p = .033), magnetoencephalography (MEG) (OR 2.90; 95% CI 1.60–5.28; p = <.001), high density (HD) EEG (OR 2.80; 95% CI 1.27–6.24; p = .011), functional MRI (fMRI) (OR 2.17; 95% CI 1.19–4.10; p = .014), and Wada (OR 2.16; 95% CI 1.28–3.66; p = .004). In the extratemporal scenario, choosing SEEG was associated with increased odds of neuromodulation over open resection (OR 3.13; 95% CI 1.24–7.89; p = .016).SignificanceIn clinical vignettes of temporal and extratemporal lesional DRE, epilepsy center directors displayed varying patterns of non‐invasive testing, invasive testing, and treatment choices. Differences in practice underscore the need for comparative trials for the surgical management of DRE.
Praying for Truth and Healing
Authors: Bara Aryz Lauwing , Wetangterah Liliya 
Published: January 2023

ABSTRACTThe 1965 tragedy in Indonesia marked a traumatic historical event which saw the start of an anti‐communist campaign of mass violence that used religion as a tool of propaganda. For three decades, those accused of being members and sympathizers of the Communist Party of Indonesia suffered violence and various civil rights restrictions. The victims are still struggling to speak the truth. This article describes how victims and their families in East Nusa Tenggara, Indonesia, formed senior prayer groups as a space for truth‐telling and healing. The groups became new families, formed based on the commonality of memory. In the groups, victims were heard and honoured, mourned together, strengthened each other, and even became reconciled. Over time, the prayer group developed into a group that facilitated joint economic empowerment. Senior prayer groups provide healing journeys for victims of the 1965 tragedy in Indonesia.
Mutahhari, Natural Rights, and Women's Exclusion from Public Life
Authors: Larijani Sareh 
Published: January 2023

AbstractGender‐based violence is a phenomenon that takes place in almost all societies around the world. It is violence directed against men or women due to their gender in various physical, sexual, psychological, and socio‐political forms. However, the majority of victims are women. Undoubtedly, gender inequality is one of the root causes of many forms of violence against women, including their exclusion from social activities. Nonetheless, misunderstanding and misinterpretation of the primary religious sources play a significant role in gender inequality in both domestic and public realms and create wounded memories for women within different communities in the name of religion. This research does not aim to investigate different forms of violence against women; rather, it intends to probe the theoretical basis of the exclusion of women from social realms. The main focus is the thought of Ayatollah Murtada Mutahhari, a 20th‐century philosopher, theologian, and traditional reformer in Iran. This study demonstrates how Mutahhari, with reference to the philosophy of natural rights, deals with unfair attitudes toward women's social activities and paves the way for their active participation in society. This study is based on library research and textual analysis.
From Midrash to Dialogue
Authors: Kamine Benjamin 
Published: January 2023

AbstractThis article argues for the utility of teaching midrash when introducing Judaism in interreligious education programmes, based on the author's experiences with the interreligious course at the Ecumenical Institute at Bossey. Midrash illuminates many aspects of Jewish meaning‐making and provides students with multiple entry points based on their learning styles. It has also long played an important role in Jewish encounters with other religious communities. And it continues to frame how contemporary Jewish thinkers connect classical Jewish sources to modern challenges. The dialogical nature of midrash creates opportunities for the students and the instructor to seek mutual understanding, generating the potential for successful dialogue encounters outside the classroom. After reflecting on how the return to in‐person learning has expanded these possibilities, the author poses several questions for further inquiry.
Time in Ecclesiastes and the Mahabharata
Authors: Thankaraj Jebin 
Published: January 2023

AbstractThis article examines the implied assumption that the concept of time in both Ecclesiastes and the Mahabharata presents a predeterministic view of human life. Such a postulation favours the argument that humans are prisoners of time who cannot overcome their plight because they think that suffering, failure, and oppression are their destiny, determined by time. The analysis suggests that Qohelet neither professes strong predeterminis‑m of time in human life nor gives humans absolute control of their life in time. The Mahabharata does not critique time and predeterminism outright but attributes importance to human endeavours and responsibilities. The acceptance of external forces like time or fate does not completely deny that human power influences destiny. Since humans have the freedom to act in the present time, it is not suitable to claim that God through time predetermines poverty, oppression, violence, and atrocities in human life.
Friendship Mission as a Healing Process after Trauma
Authors: Tiranda Petrus , Mongan Sanda 
Published: January 2023

AbstractThis article discusses friendship mission as a healing process after a traumatic experience. It builds on a case study of members of the Toraja Church, South Sulawesi, Indonesia, regarding their experiences of the Darul Islam / Indonesian Islamic Army (DI/TII) rebellion, led by Kahar Muzakkar. Using a literature review and interviews, the article offers a model of friendship mission as a solution in the process of recovering from the trauma caused by violence of the perpetrators of Kahar Muzakkar's DI/TII rebellion.
Judiciary institutions and violent crime in American Indian nations
Authors: Kern Florian G. , Gleditsch Kristian Skrede , Cordell Rebecca 
Published: January 2023

AbstractIn many American Indian nations the security situation is dire. While scholars have studied how institutions shape economic development in American Indian and Alaska Native (AIAN) nations, the role of AIAN institutions for security and violent crime has received much less attention—despite the extensive literature highlighting the important role of effective and legitimate institutions in the long‐term decline of violence. We analyze how varying types of American Indian polities and judiciary institutions fare in tackling violent crime using data across 146 American Indian polities. Our findings indicate that more autonomous American Indian criminal justice institutions with specialized court systems are associated with lower violent crime. However, customary justice institutions do not appear to be effective in reducing violent crime, highlighting the problem of cultural mismatch between traditional and formal justice systems. We argue that analyzing AIAN nations provides important insights into how institutional legitimacy can shape violent crime.
Drug information‐seeking behaviours of physicians, nurses and pharmacists: A systematic literature review
Authors: Tan Yu Xin Fiona , Lim Suzanne Tze Yin , Lim Jun Liang , Ng Tao Tao Magdeline , Chng Hui Ting 
Published: January 2023

AbstractBackgroundMedication use typically involves physicians prescribing, pharmacists reviewing, and nurses administering medications to patients. Drug information (DI) is often required during the process, with the various health care professionals (HCPs) seeking information differently according to their needs and familiarity with various resources.ObjectiveThis systematic literature review aims to evaluate studies on drug information‐seeking behaviour (ISB) of physicians, nurses and pharmacists to ascertain their DI needs, DI sources used, facilitators and barriers to DI‐seeking.MethodsA systematic search was conducted on PubMed, Embase.com, Scopus, PsycINFO, CINAHL and Cochrane Library to identify eligible primary research articles published between January 2000 and May 2020.ResultsThe reviewed studies (N = 48) revealed that HCPs have a wide range of DI needs, with the top needs being similar across the three HCPs. Information sources used most often by all three groups were tertiary, followed by human and primary sources. Factors relating to the source characteristics were the most reported facilitators and barriers to DI‐seeking. Some differences in drug ISB were also identified.ConclusionOur findings can also guide information providers and educators to optimize information provision. It may also facilitate effective communication amongst HCPs when obtaining DI from or providing DI to one another.