bluuebunny/crossref_metadata_2025_split huggingface dataset:
STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Authors: Rice Matthew R. , Matta Bharati , Wang Loretta , Indukuri Surya , Barnes Betsy J. 
Published: September 2023

AbstractToll-like receptors (TLRs) represent a subset of pattern-recognition receptors (PRRs) employed by the innate immune system to detect pathogen-associated molecular patterns (PAMPs) and initiate the response to invading microbes. The transcription factor interferon regulatory factor 5 (IRF5) functions as an important mediator of the inflammatory response downstream of MyD88-dependent TLR activation. While the dysregulation of IRF5 activity has been implicated in the development of several autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis, the factors that modulate TLR-induced IRF5 post-translational modifications (PTMs) are poorly understood. Therefore, the focus of this study was to identify and characterize the role(s) of novel kinases in the regulation of TLR7/8 signaling. We performed a kinome-wide siRNA screen in human THP-1 monocytic cells to identify mediators of TLR7/8-induced TNF-α and IL-6 production. We identified serine/threonine protein kinase 25 (STK25) as a positive regulator of proinflammatory cytokine release in response to TLR7/8 activation in human primary myeloid cells. We determined that STK25 phosphorylates IRF5in vitrovia multiple biochemical assays. Phosphopeptide mapping by mass spectrometry revealed that STK25 phosphorylates IRF5 at a highly conserved residue, Thr265, that leads to the transcriptional activation of IRF5 in HEK293T cells. We determined that STK25 undergoes autophosphorylation in response to a variety of TLR triggers in multiple immune cell types. We demonstrated that R848-induced IRF5 nuclear translocation and proinflammatory cytokine production was significantly attenuated in immune cells fromStk25-deficient mice compared to wild-type. Finally, we determined that STK25 autophosphorylation is increased at steady-state in peripheral blood mononuclear cells (PBMCs) from SLE donors compared to healthy controls. Thus, our findings implicate STK25 as an important regulator of TLR7/8 signaling through the modulation of IRF5 activation.Significance StatementThe transcription factor IRF5 functions as a master regulator of innate and adaptive immunity. While the hyperactivation of IRF5 has been implicated in the pathogenesis of systemic lupus erythematosus (SLE), the mechanisms leading to the modulation of IRF5 activity are incompletely understood. Here, we conducted a screen of the human kinome to identify IRF5 kinases that function as positive regulators of TLR-induced inflammation. We demonstrate that STK25 directly phosphorylates IRF5 to drive proinflammatory cytokine responses downstream of TLR activation in both human and murine primary immune cells. Altogether, our findings implicate STK25 as a potential therapeutic target for the management of IRF5-mediated immunological disorders.
Modelling stranded wires using homogenization and the Cauer ladder method
Authors: Koester Niels , Pichler Franz , Biro Oszkar 
Published: September 2023

Purpose
The purpose of this paper is to introduce a new method to model a stranded wire efficiently in 3D finite element simulations.

Design/methodology/approach
In this method, the stranded wires are numerically approximated with the Cauer ladder network (CLN) model order reduction method in 2D. This approximates the eddy current effect such as the skin and proximity effect for the whole wire. This is then projected to a mesh which does not include each strand. The 3D fields are efficiently calculated with the CLN method and are projected in the 3D geometry to be used in simulations of electrical components with a current vector potential and a homogenized conductivity at each time step.

Findings
In applications where the stranded wire geometry is known and does not change, this homogenization approach is an efficient and accurate method, which can be used with any stranded wire configuration, homogenized stranded wire mesh and any input signal dependent on time steps or frequencies.

Originality/value
In comparison to other methods, this method has no direct frequency dependency, which makes the method usable in the time domain for an arbitrary input signal. The CLN can also be used to interconnected stranded cables arbitrarily in electrical components.
Pyrit: A finite element based field simulation software written in Python
Authors: Bundschuh Jonas , Ruppert M. Greta , Späck-Leigsnering Yvonne 
Published: September 2023

Purpose
The purpose of this paper is to present the freely available finite element simulation software Pyrit.

Design/methodology/approach
In a first step, the design principles and the objective of the software project are defined. Then, the software’s structure is established: The software is organized in packages for which an overview is given. The structure is based on the typical steps of a simulation workflow, i.e., problem definition, problem-solving and post-processing. State-of-the-art software engineering principles are applied to ensure a high code quality at all times. Finally, the modeling and simulation workflow of Pyrit is demonstrated by three examples.

Findings
Pyrit is a field simulation software based on the finite element method written in Python to solve coupled systems of partial differential equations. It is designed as a modular software that is easily modifiable and extendable. The framework can, therefore, be adapted to various activities, i.e., research, education and industry collaboration.

Research limitations/implications
The focus of Pyrit are static and quasistatic electromagnetic problems as well as (coupled) heat conduction problems. It allows for both time domain and frequency domain simulations.

Originality/value
In research, problem-specific modifications and direct access to the source code of simulation tools are essential. With Pyrit, the authors present a computationally efficient and platform-independent simulation software for various electromagnetic and thermal field problems.
A model for improving the relationship between integrity and work performance
Authors: Konadu Kingsley , Opoku Mensah Abigail , Koomson Samuel , Abraham Ernest Mensah , Amuzu Joshua , Agyapong Joan-Ark Manu 
Published: September 2023

Purpose
Senior executives and leaders of public sector institutions (PSIs) are responsible for the development, preservation or restoration of employee integrity (EI). This conceptual paper aims to address the direct impact of EI on work performance (WP). It also explores the interceding effects of job satisfaction (JS) and employee organisational identification (OI) and the context-conditional impact of purposeful leadership (PL).

Design/methodology/approach
This research builds a research framework coupled with suppositions by integrating literature from both theoretical and empirical works in the fields of integrity management, human resource management, performance management and leadership using a systematic literature review approach. Firstly, the authors explicitly express the authors’ list of goals through replicable design. Secondly, the authors find all research papers that would satisfy the requirements for inclusion. Thirdly, the authors evaluate the truthfulness of the results from the incorporated research, and, finally, the authors offer a summary and synthesis of the features and outcomes of the incorporated research.

Findings
This study finds that EI will be favourably linked to WP, and this encouraging connection will be favourably interceded by JS and OI, both independently and together. Also, PL will favourably moderate the EI–JS connection as well as the EI–OI linkage.

Research limitations/implications
This study provides a novel framework for specialists and academics in four multidisciplinary fields for improving the EI and WP of employees using JS and OI as strategic devices. It also considers the conditional influence of PL, which has been underexploited in the academic sphere. Thus, this research sets the stage for forthcoming academics to investigate this research framework empirically in diverse PSIs worldwide.

Practical implications
To guarantee that PSIs draw, grow and preserve workers who symbolise the beliefs of the institution, their leadership must uphold a “values-grounded approach” to all facets of its human resource practises – comprising recruitment, performance appraisals, training, leadership development platforms and promotions.

Social implications
This study reveals the importance of improving integrity in PSIs and the diverse mechanisms through which EI translates into WP. It also highlights the possible benefits that purposeful leaders can offer as well as the problems that they can potentially help mitigate.

Originality/value
This research adds to the sparse literature on the construct of PL within PSIs’ settings and offers a new conceptual model for boosting employee WP through the facilitating roles of JS and OI, both separately and together.
The mediating performance role of staffing options in MNE subsidiary strategies within rapidly deteriorating environments
Authors: Georgopoulos Antonios , Aggelopoulos Eleftherios , Paraschi Elen Paraskevi , Kalogera Maria 
Published: September 2023

PurposeIn an environment of intensive global mobility, this study aims to investigate the performance role of staffing choices within diverse MNE subsidiary strategies. Incorporating the integration-responsiveness (IR) framework with a contingency perspective, this study proposes that the performance success of distinct MNE subsidiary strategies depends on staffing choices. This study argues that performance differences of staffing choices such as assigned expatriates, self-initiated expatriates, former inpatriates and host-country nationals derive from their different knowledge/experience advantages regarding the intra-firm environment and local market conditions.Design/methodology/approachThe study utilizes a unique sample of 169 foreign subsidiaries located in Greece that faced the outbreak of the COVID-19 pandemic (in 2020). For robustness reasons, this study also captures the imposition of capital controls (in June 2015).FindingsThis study finds important mediating performance effects of a diversified human resource portfolio across distinct subsidiary strategies in difficult times. Integration strategy tends to use more assigned expatriates, locally responsive strategy tends to utilize more host-country nationals, whereas multi-focal strategy favors self-initiated expatriates and former inpatriates, with positive subsidiary performance effects accordingly. So, staffing policies that are suitable to balance the needs of Human Resource Management (HRM) portfolio differ from strategy to strategy. Moreover, this study finds that managing HRM diversity is crucial in turbulent times.Originality/valueWhile the empirical evidence has been predominantly accumulated from large economies, largely neglecting performance effects of MNE subsidiary staffing in crisis contexts, the analysis sheds light on a small open economy (i.e. the Greek context) emphasizing rapidly environmental deterioration. The findings extend existing theorizing on international performance and HRM management by providing an integrative conceptual framework linking integration-responsiveness motivated strategies with distinct groups of high-quality human resources under contingency considerations, so creatively synthesizing largely fragmented IB and HRM research streams. The study provides valuable insights into the performance role of non-conventional staffing choices such as self-initiated expatriates and former inpatriates, given that relevant studies examine either exclusively expatriates or compare expatriates with host country nationals, reaching inconclusive results.
The impact of mobile applications on airline ticket purchasing behavior: a quasi-experiment
Authors: Chen Yanhong , Liu Luning , Zhang Zhenyuan 
Published: September 2023

Purpose
This paper aims to investigate the causal inferences between mobile application adoption and changes in travelers’ purchasing behavior regarding services supported by the travel and tourism industry.

Design/methodology/approach
Using a quasi-experiment conducted by an airline, data sets from more than 10,000 travelers were collected, and hypotheses were tested using propensity score matching and difference-in-difference methods.

Findings
Mobile application adoption has a significant positive effect on the total purchasing frequency of services and a significant adverse effect on booking tickets in advance and purchasing frequency from self-owned websites. Besides, this finding also suggested that members or travelers who had high average purchases in the past tend to buy more air tickets on average after mobile application adoption, while the number of days to book tickets in advance and purchase auxiliary services declined after mobile application adoption. However, males purchased more auxiliary services via mobile applications.

Research limitations/implications
The study is based on the causal effect of mobile application adoption on purchasing behavior. Nevertheless, the theoretical basis remains relatively weak. Furthermore, the underlying mechanisms that cause the changes in purchasing behavior via mobile applications need to be elucidated.

Practical implications
This study enriches the hospitality and tourism literature on mobile application adoptions, multichannel purchasing behavior and revenue management. First, a quasi-experimental design is used to verify a causal relationship between mobile applications’ adoption and travelers’ purchasing behavior in the travel and tourism industry. Second, this study adds to examining travelers’ multichannel purchasing behavior in the travel and tourism industry. Third, this work enriches the current literature that explores auxiliary services and revenue management in the travel industry.

Originality/value
Mobile application adoption significantly impacted the travel and tourism industry. Besides, To the best of the authors’ knowledge, this is one of the first empirical studies that examined changes in purchasing behavior due to mobile application adoption from the perspective of service type. The findings provide the first evidence of the impact of mobile application adoption on service purchasing in the travel industry.
Organizational resilience as the mediator of relation between brand performance and organizational performance – reflections from the perspective of crisis times
Authors: Zabłocka-Kluczka Anna , Sałamacha Anna Katarzyna 
Published: September 2023

PurposeThe role of brand management in contemporary organizations is very important and consistently growing due to the increasingly difficult competitive conditions on the market. Moreover, the significance of organizational resilience in this process should be noticed, especially in the times of emerging crises. In this context, the purpose of this article is to examine the mediating role of organizational resilience in the relation between brand performance and organizational performance.Design/methodology/approachIn order to verify the potential relations, empirical studies were conducted in 268 organizations located in Poland. The CAWI method was used in this research, while the companies were selected on the basis of the purposive manner. The reliability of the scales used in the survey was tested and afterwards the mediation model was built, confirming the presumed relationships between the variables. The calculations were made using the PS Imago Pro and Process macro for SPSS ver. 3.4 by Andrew F. Hayes.FindingsIt has been proven that organization's resilience partially mediates the relationship of brand performance and organizational performance.Research limitations/implicationsFirst of all, the scope of the research covered only Poland, and the obtained results may differ between countries with diversified market characteristics. Second of all, the study was not carried out in a representative manner, it concerned 268 companies that were selected based on the purposive method. Third of all, consideration focused only on one feature – organizational resilience. It would be valuable to include other features to discussion. Finally, the research was conducted in December 2019, so it seems justified to repeat the survey in conditions of modern reality.Originality/valueThis study is the first that showed the relationship between brand performance and organizational resilience and its meaning for organizational performance.
The rise of regenerative hospitality
Authors: Inversini Alessandro , Saul Lionel , Balet Sarah , Schegg Roland 
Published: September 2023

PurposeThe concept of “regenerative business” is thriving in current business literature. The present study seeks to contribute to the current academic debate by investigating the nature and scope of regenerative hospitality, here seen as a steppingstone of regenerative tourism.Design/methodology/approachExploratory in nature and with the goal of understating the nature and scope of regenerative hospitality, nineteen semi-structured interviews with academics, consultants and self-proclaimed regenerative hoteliers were conducted.FindingsResults provide a regenerative hospitality framework to move from the current sustainability paradigm towards local and systemic regenerative approaches in hospitality by applying place and people intelligence.Originality/valueThis research contributes to the current academic debate about the future of travel, particularly focussing on the future of hospitality in relation to the multidisciplinary field of regenerative economy. Particularly, the paper has been designed to contribute to the current discussion in the Journal of Tourism Futures about the transformation and regenerative future of tourism.
The cultural logics of mothering practices: agency capacity of the university-educated Chinese mothers in Singapore and Hong Kong
Authors: Yeung Sin Sin 
Published: September 2023

Purpose
This study aims to reveal and compare the cultural logics of university-educated Chinese mothers in Singapore and Hong Kong in their mothering practices to improvise their femininities in constituting their work–family interactions.

Design/methodology/approach
This qualitative research, with the ethnographic elements, has included 32 Chinese mothers to share about their mothering experiences through semi-structured interviews. This methodological design with feminist lens embraces women’s own narratives as sources of knowledge and learns their voices to reinvent their role and bodily engagement in shaping their family dynamics.

Findings
This discussion basically reaffirms the argument where the mother’s involvement in their children’s schoolwork becomes one of the core elements in their actual everyday mothering practices. It has further reflected the dynamics of family quality time in the light of mothers’ cultural logics as much as their attentive agency capacity to present their respectable femininity in the form of mothering.

Research limitations/implications
This research process has revealed the actual experiences of the participants from their own narratives. For future research development, data collection can be extended to include the husbands’ profiles and their narratives in understanding their wives’ mothering experiences.

Originality/value
This discussion enriches the work-family literature by extending it to the Asian Chinese context. While the concepts of cultural capital and habitus have been addressed in previous studies, this discussion highlights the agency capacity of the university-educated Chinese mothers in their cultural logics to deliver their respective mothering practices. This filtering process to transmit cultural capital to their children is as much as they involve in reproducing status boundaries for the family.
Patients with keratinization disorders due to ABCA12 variants showing pityriasis rubra pilaris phenotypes
Authors: Takeichi Takuya , Hamada Takahiro , Yamamoto Mayuko , Ito Yasutoshi , Kawaguchi Aya , Kobashi Haruka , Yoshikawa Takenori , Koga Hiroshi , Ishii Norito , Nakama Takekuni , Muro Yoshinao , Ogi Tomoo , Akiyama Masashi 
Published: September 2023

AbstractPathogenic variants in ABCA12 are important causative genetic defects for autosomal recessive congenital ichthyoses (ARCI), which include congenital ichthyosiform erythroderma (CIE), harlequin ichthyosis, and lamellar ichthyosis. In addition, pathogenic variants in ABCA12 are known to cause a localized nevoid form of CIE due to recessive mosaicism. We previously reported siblings who carried an ABCA12 variant but did not show a “congenital” phenotype. They were considered to have pityriasis rubra pilaris (PRP). Here, we present a further patient with ABCA12 variants whose phenotype was not congenital ichthyosis, in an independent family. Notably, these three patients had geographic unaffected areas. Such areas are not usually found in patients with ARCI who have ABCA12 variants, suggesting mild phenotypes for these patients. Interestingly, the histological features of the ichthyotic lesions in these patients resembled those of PRP. All three patients had homozygous pathogenic missense variants in ABCA12. Our findings expand the phenotypic spectrum of patients with ABCA12 variants.
Diversity of seed storage behavior of tree species from tropical lowland rainforests in Sri Lanka, a global biodiversity hotspot
Authors: Samarasinghe B. R. Chandima P. , Jayasuriya K. M. G. Gehan , Gunaratne A. M. Thilanka A. , Dixon Kingsley W. , Senanayaka Mahesh C. 
Published: September 2023

AbstractTropical lowland rainforests are considered to be ecologically important refugia of national and global significance, yet wide‐scale deforestation and degradation of tropical lowland rainforests lead to losses in biodiversity. Seed storage behavior information is required for the effective restoration of these forests. Here, we studied the seed storage behavior of 42 selected tropical lowland rainforest tree species from Sri Lanka with the aim to test the reliability of current experimental methods and predictive models to predict the desiccation sensitivity of seeds. Seed storage behavior was experimentally determined through the 100 seed method and the results were compared with three predictive models; thousand seed weight–moisture content (TSW–MC), seed coat ratio–seed mass (SCR–SM), and phylogenetic affiliation models. Based on the 100 seed method, 28 species were identified as desiccation sensitive and 14 species were identified as desiccation tolerant. Compared to the 100 seed method, the predictability of the SCR–SM model was 70%, whereas the TSW–MC and phylogenetic affiliation models showed 52% and 58% predictability, respectively. Due to its higher predictability, the SCR–SM model has a high potential to be an effective predictive tool of seed storage behavior. This study revealed that tropical lowland rainforests are dominated by trees producing desiccation‐sensitive seeds. Further, species dispersing seeds in the peak rainy season have desiccation‐sensitive seeds, while those dispersing seeds in the normal wet season have desiccation‐tolerant seeds. Another key finding was that 100% of the subcanopy species produce nonorthodox, that is, desiccation‐sensitive seeds, which gradually decrease from subcanopy to understory.