bluuebunny/crossref_metadata_2025_split huggingface dataset:
The assessment of carrying capacity of marine fishery resources in China
Authors: Liu Zhaoyang , Lu Wenhai , Wang Tao , Zhang Yujia , He Long , Yang Lu , Deng Lijing 
Published: January 2025

IntroductionThe sustainable development of marine fisheries has been a major concern, with the carrying capacity of marine fishery resources becoming a focal point of research.MethodsThis study, utilizing remote sensing data, marine capture fisheries catch data, and fishing effort data from 2013 to 2020, aims to determine the maximum sustainable yield using a surplus production model and provide a comprehensive assessment of the status and potential of China’s marine fishery resources.ResultsThe results indicate that China’s marine fishery resources exhibit significant regional variability, with the East China Sea contributing the largest share of catch and maintaining sustainability, while regions such as the South China Sea, Yellow Sea, and Bohai Sea have exceeded their ecological carrying capacities. Correlation analysis highlights that nutrient levels and water quality (e.g., chemical oxygen demand) are critical for resource stability, while the distribution and management of protected areas further influence carrying capacity.DiscussionThis study contributes to the development of more effective fishery policies, aiming to balance economic benefits with ecological health. By understanding these dynamics, policymakers can better address the challenges facing sustainable marine fisheries.
Impact of smart city construction policy on high-quality economic development of coastal cities
Authors: Wang Lihong , Li Feng , Gao Yang , Yin Kedong 
Published: January 2025

IntroductionAs a crucial strategy for promoting urbanization in China, smart city construction introduces new momentum for high-quality economic development through intelligence and informatization. Coastal cities, with their unique geographical and economic advantages, serve as important engines of high-quality economic growth.MethodsBased on panel data from 53 coastal cities in China from 2003 to 2021, this study uses the super-efficiency SBM-GML index to measure green total factor productivity as an indicator of high-quality economic development and employs a time-varying difference-in-differences model to examine the impact of smart city construction on high-quality economic development in coastal areas.ResultsThe findings reveal that (1) Smart city construction significantly enhances high-quality economic development in coastal cities. This conclusion remains valid in parallel trend tests, PSM-DID, placebo tests and endogeneity analysis. (2) The mechanism test shows that smart city construction development primarily promotes high-quality economic growth in coastal cities by facilitating industrial structural upgrading, optimizing resource allocation, and release household consumption potential and expanding domestic demand. However, technological innovation, which is the most important aspect of smart city construction, has not brought new opportunities for high-quality economic development in coastal cities. (3) Heterogeneity analysis shows that the policy effects of smart city are more pronounced in large cities and those with lower levels of scientific and educational development. Additionally, the impact is particularly significant in cities located within the Bohai Rim and Yangtze River Delta port clusters.DiscussionBased on these findings, continued support for smart city construction is recommended, with differentiated policies tailored to the characteristics of coastal cities and port cluster development levels, alongside advancing industrial structural upgrading, optimizing resource allocation, and fostering new points of consumption growth to promote high-quality economic development in China’s coastal cities.
Evaluation of drug prescribing pattern based on World Health Organization drug use indicators in dermatology outpatient department of Injibara General Hospital, Northwest Ethiopia, 2024
Authors: Tegegnie Alemu Bezabih , Alene Tamiru , Bogale Habtamu Nega , Tamir Workineh , Sineshaw Meaza Molla 
Published: January 2025

BackgroundIrrational use of medicines is a problem globally that soon needs to be addressed. According to estimates from the World Health Organization, almost half of all medications were improperly prescribed. This study aimed to assess the drug prescribing patterns based on World Health Organization drug use indicators in the dermatology outpatient department of Injibara General Hospital.MethodA facility-based retrospective cross-sectional study was conducted from August 15 to August 30, 2024, with 620 patient prescriptions issued at the dermatology outpatient department of Injibara General Hospital. All patient prescriptions dispensed from the dermatology outpatient department from April to July 2024 were included. A structured data collection tool adopted from the World Health Organization core medicine use indicator was used to collect data, and Statistical Package for Social Science version 27.1 was used for data analysis.ResultsAn average of 1.74 drugs per encounters was prescribed, with 21.6 and 3.1% of prescriptions being antibiotics and injections, respectively. Generics were used in 95.4% of prescriptions, and nearly 84% of drugs were prescribed from the Ethiopian essential-drug list.ConclusionThe World Health Organization’s recommended threshold for the average number of prescriptions prescribed per encounter was met, indicating proper prescribing practices that reduce polypharmacy. The percentage of encounters with antibiotics was within the World Health Organization’s value, which reflects that dermatologists are less likely engaging in irrational antibiotic prescriptions. Likewise, the World Health Organization’s recommendations for the percentage of encounters with injection was met, indicating an effort to minimize unnecessary use of injections by dermatologists, which can reduce complications associated with injection use. However, the World Health Organization’s guidelines for generic drug prescriptions were not met, suggesting that dermatologists are less likely to prescribe generic drugs, which can raise patient healthcare expenditures considerably. Prescriptions from the Ethiopian essential medicine list also fell short of World Health Organization’s standards, indicating a failure to follow established guidelines.
Predictors of HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients treated with nucleotide analogs plus polyethylene glycol interferon
Authors: Peng Yan , Ma Mingzhe , Liu Ting , He Wenmin , Lin Shutao , Zhong Wa , Min Xiaohui 
Published: January 2025

IntroductionThe minority of the chronic hepatitis B (CHB) patients received polyethylene glycol interferon (PEG-IFN) combined with nucleotide analogs (NAs) can obtain hepatitis B surface antigen (HBsAg) clearance.MethodsIn order to find out the advantaged population, we retrospectively collected 122 CHB patients treated with NAs alone or NAs plus PEG-IFN for 48 weeks, who were admitted to Sun Yat-sen Memorial Hospital from 2019 to 2024.ResultsWe found HBsAg clearance rate in NAs plus PEG-IFN group was 40.98%, which was significantly higher than that in the NAs group. Thus, NAs plus PEG-IFN therapy served as a relatively ideal regimen and the patients received combined treatment were then incorporated for further analysis for searching efficacy predictors. Through using univariate and multivariate analysis, we confirmed the predictive value of HBsAg, alanine aminotransferase (ALT) at week 24, and ALT change values from baseline to week 24. The area under the receiver operating characteristic (ROC) curve of each indicators ranged from 0.663 to 0.982.DiscussionIn conclusion, our study verified the clinical value of NAs plus PEG-IFN for treating CHB patients. Moreover, for the first time, we found ALT change values from baseline to week 24 (dALT2) could act as a novel independent clinical efficacy predictors in the forementioned population.
Effects of rosemary extract and its residue on production, immune performance, and gut microbiota in geese
Authors: Huang Yuzhi , Xu Lanmeng , He Hang , Peng Lijuan , Liao Qinfeng , Wan Kun , Qin Simeng , Cao Lijing , Zhang Jie 
Published: January 2025

IntroductionTo explore the effects of rosemary extract (RE) and its residue (RR) on the production, immune performance, and gut microbiota of geese.MethodsWe treat 28-day-old Sichuan white geese (n = 180) with three diets: (1) basal diet (control), (2) basal diet supplemented with 0.02% RE, and (3) basal diet supplemented with 15% RR for 42 days.Results and discussionOn day 70, compared with control treatment, the final body weight, average daily gain and lysozyme levels in the RE treatment increased significantly (p &lt; 0.05). In the RE and RR treatments, there was a significant decrease in alkaline phosphatase, globulin, and high-density lipoprotein levels compared to the control treatment, and there was also a significant increase in aspartate aminotransferase/alanine aminotransferase (p &lt; 0.05). Moreover, for both RE and RR treatments, semi-eviscerated, eviscerated weights, and calcium apparent digestibility increased significantly, along with a decrease in the duodenal index (p &lt; 0.05). Compared with RE treatment, those in the RR treatment had significantly higher duodenal and jejunum relative lengths, aspartate aminotransferase, uric acid, total cholesterol, and low-density lipoprotein levels, and decreased chest depth, chest angle, neck length, semi-eviscerated and eviscerated weights, crude protein digestibility, and levels of globulin, triglyceride, and lysozyme (p &lt; 0.05). There were no differences in gut microbiota α or β diversities among treatments (p &gt; 0.05). Compared to the control treatment, the relative abundance of Turicibacter significantly increased in the RR and RE treatments, and the relative abundance of Sporobacter, Alistipes, and Barnesiella significantly increased in the RR treatment (p &lt; 0.05). Rikenellaceae, Succinivibrionaceae, and Aeromonadales were enriched in the RR treatment, and Lachnospiraceae, Turicibacteraceae, Fusobacteriaceae, and Enterobacteriaceae were enriched in the RE treatment. While we demonstrate the RR diet to be less effective than the RE diet, it did improve production and the gut microbiota of geese to a certain extent.
Protocol for a Phase 2 randomized controlled patient-assessor blinded study: efficacy and safety of combined cortical and cerebellar dual-target transcranial magnetic stimulation for the treatment of essential tremor
Authors: Xu Jing , Cao Na , Qu Yan , Shang Suhang , Liu Xincheng , Wang Xuexin , Hu Fangfang , Bai Xuerong , Qu Qiumin , Zhang Meng , Cao Hongmei 
Published: January 2025

BackgroundEssential tremor (ET) is the most common neurological movement disorder with few treatments and limited therapeutic efficacy, research into noninvasive and effective treatments is critical. Abnormal cerebello-thalamo-cortical (CTC) loop function are thought to be significant pathogenic causes of ET, with the cerebellum and cortex are common targets for ET treatment. In recent years, transcranial magnetic stimulation (TMS) has been recognized as a promising brain research technique owing to its noninvasive nature and safety. In this study, we will use left M1 cortex continuous theta-burst stimulation (cTBS) combined with right cerebellar hemisphere 1 Hz repetitive transcranial magnetic stimulation (rTMS) dual-target stimulation to explore the Safety, feasibility and efficiency of this dual-target stimulation mode, and the mechanism of its therapeutic effect.MethodsTwenty-four patients with ET will be randomly assigned to three groups: dual-target stimulation, single-target stimulation, or sham stimulation. The single-target stimulation group will receive stimulation of the right cerebellar hemisphere for 10 days, whereas the dual-target stimulation group will be given stimulation of both the left M1 cortex and the right cerebellar hemisphere. The sham stimulation group will be given sham stimulation for 10 days. Tremor will be assessed using both the subjective The Essential Tremor Rating Assessment Scale (TETRAS) and objective accelerometer-based tremor analysis. at baseline (before stimulation), after the first, fifth, tenth days of treatment (D1, 5, 10), 24 h after 10 days of treatment (D10-24 h), and 1, 2, 3, and 4 weeks after stimulation (W1, 2, 3, 4).DiscussionThis is a Phase 2 randomized, controlled, patient-assessor blinded clinical trial. The goal of this study is to investigate the Safety, feasibility and efficiency of TMS for the treatment of ET.
Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease?
Authors: Goris Maaike , Ginis Pieter , Hansen Clint , Schlenstedt Christian , Hausdorff Jeffrey M. , D’Cruz Nicholas , Vandenberghe Wim , Maetzler Walter , Nieuwboer Alice , Gilat Moran 
Published: January 2025

IntroductionFreezing of gait (FOG) is a disabling symptom for people with Parkinson’s disease (PwPD). Turning on the spot for one minute in alternating directions (360 turn) while performing a cognitive dual-task (DT) is a fast and sensitive way to provoke FOG. The FOG-index is a widely used wearable sensor-based algorithm to quantify FOG severity during turning. Despite that, the FOG-index’s classification performance and criterion validity is not tested against the gold standard (i.e., video-rated time spent freezing). Therefore, this study aimed to evaluate the FOG-index’s classification performance and criterion validity to assess FOG severity during 360 turn. Additionally, we investigated the FOG-index’s optimal cutoff values to differentiate between PwPD with and without FOG.Methods164 PwPD self-reported the presence of FOG on the New Freezing of Gait Questionnaire (NFOGQ) and performed the DT 360 turn in the ON medication state while being videoed and wearing five wearable sensors. Two independent clinical experts rated FOG on video. ROC-AUC values assessed the FOG-index’s classification accuracy against self-reported FOG and expert ratings. Spearman-rho was used to evaluate the correlation between expert and FOG-index ratings of FOG severity.ResultsTwenty-eight patients self-reported FOG, while 104 were classified as a freezer by the experts. The FOG-index had limited classification agreement with the NFOGQ (AUC = 0.60, p = 0.115, sensitivity 46.4%, specificity 72.8%) and the experts (AUC = 0.65, p &lt; 0.001, sensitivity 68.3%, specificity 61.7%). Only weak correlations were found between the algorithm outputs and expert ratings for FOG severity (rho = 0.13–0.38).ConclusionA surprisingly large discrepancy was found between self-reported and expert-rated FOG during the 360 turning task, indicating PwPD do not always notice FOG in daily life. The FOG-index achieved suboptimal classification performance and poor criterion validity to assess FOG severity. Regardless, 360 turning proved a sensitive task to elicit FOG. Further development of the FOG-index is warranted, and long-term follow-up studies are needed to assess the predictive value of the 360 turning task for classifying FOG conversion.
Diet quality and physical activity affect metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and etiology-associated steatohepatitis, and compensated advanced chronic liver disease among United States adults: NHANES 2017–2020
Authors: Wang Peng , Xia Bingxin , Wang Shuang 
Published: January 2025

Background and aimClinical data on the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and etiology-associated steatohepatitis (MetALD) in a multi-ethnic U.S. population are limited. Additionally, the impact of physical activity (PA) and diet quality (DQ) on the risk of MASLD, MetALD, and compensated advanced chronic liver disease (cACLD) remains unclear. This study aimed to investigate the associations of PA and diet quality with the risks of MASLD, MetALD, and cACLD.Methods and resultsThis cross-sectional study analyzed data from 7,125 participants in the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Diet quality was assessed using the Healthy Eating Index-2015 (HEI-2015). PA was assessed based on the 2020 WHO Physical Activity Guidelines, with participants reporting the intensity, frequency, and duration of their activities over the past 7 days. MASLD and MetALD were diagnosed based on clinical criteria, and cACLD was defined by advanced liver fibrosis. Bivariate and multivariable logistic regression models were used to assess associations between PA, diet quality, and liver disease outcomes. The prevalence of MASLD and MetALD was 35.07 and 21.46%, respectively. HQD was associated with significantly lower risks of MASLD (OR: 0.49, 95% CI: 0.38–0.62) and MetALD (OR: 0.45, 95% CI: 0.36–0.56). High PA levels were linked to reduced risks of MASLD (OR: 0.47, 95% CI: 0.38–0.58) and MetALD (OR: 0.53, 95% CI: 0.39–0.72). The lowest risks for both MASLD and MetALD were observed in highly active participants with an HQD (MASLD OR: 0.41, 95% CI: 0.32–0.53; MetALD OR: 0.54, 95% CI: 0.41–0.71). Significant interactions were observed between PA, HQD, and age, BMI, and SES, which further reduced the risks of MASLD and MetALD. For cACLD, both increased PA and HQD were associated with reduced risk. Compared to non-high-activity participants with a non-HQD, physically active participants with an HQD had the lowest risk of cACLD (OR: 0.44, 95% CI: 0.24–0.82).ConclusionHigh proportions of the US population have MASLD or MetALD. HQD and high PA levels were associated with lower risks of MASLD, MetALD, and cACLD.
Dietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study
Authors: Liu Dong , Liu Ziwei , Wu Yue , Hong Yan , Fang Jinghao , Lu Ying , Xu Guangfei , Kang Peipei , Liu Tong , Chen Li-Hua 
Published: January 2025

BackgroundTriglyceride glucose (TyG) index has been proposed as a credible and simple surrogate indicator for insulin resistance. The primary aim of this study was to novelly examine the associations between dietary patterns reflecting variations in circulating TyG index and the risk of type 2 diabetes mellitus (T2DM).MethodsThis study included 120,988 participants from the UK Biobank, all of whom completed multiple 24-h dietary assessments. Dietary pattern scores were derived using reduced-rank regression (RRR) and Least Absolute Shrinkage and Selection Operator (LASSO) regression, based on the TyG index and approximately 80 food groups. The associations between the TyG index, related dietary pattern scores, and T2DM risk were evaluated using Cox regression models.ResultsDuring a median follow-up period of 11.2 years, 3,585 participants developed T2DM. A higher TyG index was significantly associated with an increased risk of T2DM. The two dietary patterns derived from RRR and LASSO showed a strong correlation (ρ = 0.88, p &lt; 0.001) and shared similar characteristics at higher scores, including greater intakes of margarine, meat, fruit juice, and potatoes, alongside lower intakes of green vegetables, oily fish, yogurt, nuts and seeds, and dried fruits. Corresponding blood profiles, including elevated levels of C-reactive protein and HbA1c, along with reduced levels of HDL-C and docosahexaenoic acid, substantiated the dietary pattern assessments. The adjusted hazard ratios (HRs) for T2DM risk were 1.52 (95% CI: 1.33–1.73, p trend &lt;0.001) and 1.48 (95% CI: 1.30–1.69, p trend &lt;0.001) for dietary patterns derived using RRR and LASSO, respectively, comparing the highest to the lowest quintiles.ConclusionThe findings suggest that a higher TyG index and specific dietary patterns, characterized by higher intakes of margarine, meat, fruit juice, and potatoes, and lower intakes of green vegetables, oily fish, yogurt, nuts and seeds, and dried fruits, are associated with an increased risk of developing T2DM. These results underscore the potential of dietary modifications targeting these patterns to mitigate T2DM risk.
Does the habitual dietary intake of adults in Bavaria, Germany, match dietary intake recommendations? Results of the 3rd Bavarian Food Consumption Survey
Authors: Rohm Florian , Wawro Nina , Gimpfl Sebastian , Ohlhaut Nadine , Senger Melanie , Röger Christine , Kussmann Martin , Gedrich Kurt , Linseisen Jakob 
Published: January 2025

ObjectiveMonitoring dietary habits is crucial for identifying shortcomings and delineating countermeasures. About 20 years after the last population-based surveys in Bavaria and Germany, dietary habits were assessed to describe the intake distributions and compare these with recommendations at food and nutrient level.MethodsThe 3rd Bavarian Food Consumption Survey (BVS III) was designed as a diet survey representative of adults in Bavaria; from 2021 to 2023, repeated 24-h diet recalls were collected by telephone using the software GloboDiet©. Food (sub-)group and nutrient intake data were modeled with the so-called NCI method, weighted for the deviation from the underlying population. Intake distributions in men and women were described as percentiles. These data were used to estimate the proportion of persons meeting dietary intake recommendations. In addition, food consumption data were compared with the results reported 20 years ago collected by the same methodology (2nd Bavarian Food Consumption Survey, BVS II).ResultsUsing 24-h diet recalls of 550 male and 698 female participants, we estimated intake distributions for food (sub-)groups and nutrients. A major proportion of the adult population does not meet the food-based dietary guidelines; this refers to a series of food groups, including fruit and vegetables, legumes, nuts, cereal products, and especially whole grain products, as well as fresh and processed meat. Regarding selected essential nutrients, a considerable proportion of the population was at higher risk of insufficiency from iron (women), zinc (men), and folate (both men and women), as already described in previous studies.ConclusionA major proportion of the adult Bavarian population does not meet the current food-based dietary guidelines. Compared to BVS II data, favorable changes refer to lower consumption of total meat (especially processed meat) and soft drinks, and an increased intake of vegetables. The conclusions based on the intake of selected essential nutrients hardly changed over time. From a public health perspective, the still low intake of vegetables, fruit, nuts, cereal products, and particularly of whole grain products, and associated higher risks of insufficient supply of several vitamins and minerals call for action for improvement.