bluuebunny/crossref_metadata_2025_split huggingface dataset:
No difference in bacterial contamination of hip capsule sutures and control sutures in hip arthroplasty surgery
Authors: van Schaik Thomas J. A. , van Meer Maurits P. A. , de Jong Lex D. , Goosen Jon H. M. , Somford Matthijs P. , van Susante Job L. C. 
Published: September 2023

Abstract
Background
Perioperative preventive measures are important to further reduce the rate of periprosthetic joint infections (PJI) in patients undergoing total hip arthroplasty (THA). During THA surgery, joint capsule sutures are commonly placed to optimize exposure and reinsertion of the capsule. Bacterial contamination of these sutures during the procedure poses a potential risk for postoperative infection. In this exploratory study, we assessed the contamination rate of capsule sutures compared to the contamination of the remains of exchanged control sutures at the time of closure.

Methods
In 100 consecutive patients undergoing primary THA capsule sutures were exchanged by sterile sutures at the time of capsule closure. Both the original sutures and the remainder of the newly placed (control) sutures were retrieved, collected and cultured for ten days. Types of bacterial growth and contamination rates of both sutures were assessed.

Results
Sutures from 98 patients were successfully collected and analyzed. Bacterial growth was observed in 7/98 (7.1%) of the capsule sutures versus 6/98 (6.1%) of the control sutures, with a difference of 1% [CI -6–8]. There was no clear pattern in differences in subtypes of bacteria between groups.

Conclusions
This study showed that around 7% of capsule sutures used in primary THA were contaminated with bacteria and as such exchange by new sutures at the time of capsule closure could be an appealing PJI preventive measure. However, since similar contamination rates were encountered with mainly non-virulent bacteria for both suture groups, the PJI preventive effect of this measure appears to be minimal.
The effects of using analytical rubrics in peer and self-assessment on EFL students’ writing proficiency: a Vietnamese contextual study
Authors: Phuong Hoang Yen , Phan Quoc Toan , Le Thanh Thao 
Published: September 2023

AbstractThis research investigates the effectiveness of utilizing analytic rubrics in peer-assessment (PA) and self-assessment (SA) methodologies to enhance the proficiency of English as a Foreign Language (EFL) students’ essay writing skills in the Vietnamese context. It further contributes to the existing body of literature regarding formative assessment and its potential to improve student learning outcomes. A total of 44 university students, all English majors, were divided into two distinct groups, each consisting of 22 participants. One group applied analytic rubrics for SA, while the other used the same tool for PA. The writing performance of the two groups was assessed and compared in pre and post-tests. The findings revealed no significant difference between the SA and PA groups in the pre-test. However, in the post-test, the SA group demonstrated significantly superior performance compared to the PA group, with noticeable improvements across all evaluated criteria. Moreover, these results showed that the use of analytic rubrics in SA and PA methods positively impacted the EFL students’ writing skills, particularly in the areas of content and language use. This has practical implications for teachers, curriculum developers, and policymakers in designing and implementing formative assessment strategies for EFL learners. Further research is needed to examine the long-term effects of employing analytic rubrics, and to understand the potential influence of other contextual factors on student learning outcomes.
Art historical and scientific controversies about four easel paintings attributed to Kamal al-Molk, the renowned nineteenth-twentieth century Persian painter
Authors: Roohi Sima , Holakooei Parviz 
Published: September 2023

Abstract
Pigments on four easel paintings signed by Mohammad Ghaffari (latter Kamal al-Molk), the renowned Persian painter lived from the mid-nineteenth to the mid-twentieth century, kept at the Astan-e Qods-e Razavi Museum (AQRM) in Mashhad, Iran, were identified by micro-X-ray fluorescence (µ-XRF), scanning electron microscopy—energy dispersive X-ray spectrometry (SEM–EDS) and micro-Raman spectroscopy (µ-Raman). Apart from chrome yellow, green chromium oxide and red ochre, four blue pigments including Prussian blue, artificial ultramarine blue, azurite, blue phthalocyanine PB:16 and seven white pigments including rutile, huntite, lead white, baryte, chalk, gypsum and zinc white were identified on the paintings. Based on the occurrence of rutile and blue phthalocyanine PB:16 and the fact that the signature of the paintings suggests 1875 as the date of executing the paintings, several hypotheses were argued to discuss the latter interventions and the authenticity of the works. Discussions on the birth date and other important milestones of Kamal al-Molk’s life accordingly posed serious questions on the authenticity of these paintings.
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Authors: Bertin Francisca , Jara-Wilde Jorge , Auer Benedikt , Köhler-Solís Andrés , González-Silva Carolina , Thomas Ulrich , Sierralta Jimena 
Published: September 2023

AbstractBackgroundThe endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move structural proteins, proteins that send signals, and lipids over long distances. Atlastin (Atl), a large GTPase, is required for membrane fusion and the structural dynamics of the ER tubules. Atl mutations are the second most common cause of Hereditary Spastic Paraplegia (HSP), which causes spasticity in both sexes’ lower extremities. Through an unknown mechanism, Atl mutations stimulate the BMP (bone morphogenetic protein) pathway in vertebrates and Drosophila. Synaptic defects are caused byatlmutations, which affect the abundance and distribution of synaptic vesicles (SV) in the bouton. We hypothesize that BMP signaling, does not cause Atl-dependent SV abnormalities in Drosophila.ResultsWe show thatatlknockdown in motor neurons (Atl-KD) increases synaptic and satellite boutons in the same way that constitutively activating the BMP-receptor Tkv (thick veins) (Tkv-CA) increases the bouton number. The SV proteins Cysteine string protein (CSP) and glutamate vesicular transporter are reduced in Atl-KD and Tkv-CA larvae. Reducing the activity of the BMP receptor Wishful thinking (wit) can rescue both phenotypes. Unlike Tkv-CA larvae, Atl-KD larvae display altered activity-dependent distributions of CSP staining. Furthermore, Atl-KD larvae display an increased FM 1–43 unload than Control and Tkv-CA larvae. As decreasingwitfunction does not reduce the phenotype, our hypothesis that BMP signaling is not involved is supported. We also found that Rab11/CSP colocalization increased in Atl-KD larvae, which supports the concept that late recycling endosomes regulate SV movements.ConclusionsOur findings reveal that Atl modulates neurotransmitter release in motor neurons via SV distribution independently of BMP signaling, which could explain the observed SV accumulation and synaptic dysfunction. Our data suggest that Atl is involved in membrane traffic as well as formation and/or recycling of the late endosome.
"We are watching you": investigation of consumer-employee perception gaps and the employee expectations-employer performance gaps
Authors: Lee Stacy H. , Jung Sojin , Ha-Brookshire Jung 
Published: September 2023

AbstractBased on the social contract theory and social exchange theories, this study examined the Corporations’ social responsibility (CSR) gaps perceived by fashion firms’ internal (i.e., employees) and external (i.e., consumers) stakeholders. In addition, to more deeply understand employees’ perspectives, this study empirically measured the CSR performance gap between employees’ expectations for the CSR standards the industry should achieve and employees’ perceptions of their employers’ CSR performance. This study then explored how the extent of negative incongruence (i.e., when the employer’s CSR performance does not meet the employee’s CSR standards) influenced employees’ attitudes and behaviors with the moderating role of the employees’ work experience. For this, we selected two global fashion firms: H&M and Nike. Through an online survey, 865 usable responses were collected (H&M retail employee n = 158, consumer n = 275; Nike retail employee n = 157, consumers n = 275). One-way Analysis of Variance and a post hoc test showed that the consumer groups for H&M and Nike indicated significantly lower levels of CSR perceptions than those of the employees of each brand. Moreover, the results of structural equation modeling revealed that negative incongruence between the expected industry standard and perceptions of the firm's performance in the area of CSR discouraged organizational commitment, which in turn decreased organizational citizenship behavior and increased turnover intentions. The moderating effect of work experiencewas not found. The originality of this study is that it quantitatively examined both internal and external stakeholders’ CSR perceptions and employees’ CSR perception gaps. The findings provide valuable academic and managerial implications.
Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus
Authors: Huang Xinmei , Li Yue , Tong Xiaoxu , Wu Yueyue , Zhang Rui , Sheng Li , Xu Jiong , Yu Zhiyan , Chen Zaoping , Sun Tiange , Wang Fang , Yang Qian , Li Zhangyan , Gao Cuijun , Ma Ling , Ding Heyuan , Zang Shufei , Yang Ni , Zhang Tie-Ning , Liu Jun 
Published: September 2023

Abstract

Objective
Placenta-derived inflammation plays a vital role in the pathophysiology of gestational diabetes mellitus (GDM). IL-32 is a novel pro-inflammatory cytokine and metabolic regulator involved in the development of metabolic disease. We investigated the effect of IL-32 in GDM.

Materials and Methods
First-trimester C-reactive protein (CRP) level was monitored in a case-control study of 186 women with GDM and 186 women without. Placental tissue was lysed and analyzed by high-resolution liquid chromatography-tandem mass spectrometry. Circulating level of inflammatory cytokines IL-32, IL-6, and TNF-α were measured by ELISA kits. The expression of placenta-derived macrophages, inflammatory cytokines, and related pathway proteins were assessed by reverse transcriptase-quantitative PCR, western blot, immunohistochemistry, or immunofluorescence.

Results
First-trimester CRP level in peripheral blood was closely associated with glucose and insulin resistance index and was an independent correlation with the development of GDM. High-resolution liquid chromatography-tandem mass spectrometry revealed that placenta-derived CRP expression was dramatically elevated in women with GDM. Interestingly, the expression of placenta-derived IL-32 was also increased and located in the macrophages of placental tissue. Meanwhile, the expression of IL-6, TNF-α, and p-p38 were up-regulated in the placental tissues with GDM. Either IL-6 or TNF-α was colocated with IL-32 in the placental tissue. Importantly, circulating IL-32 throughout pregnancy was increased in GDM and was related to placental-derived IL-32 expression, circulating IL-6, and TNF-α, glucose and insulin resistance index.

Conclusion
Increased circulating IL-32 throughout pregnancy was closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
The Evolving Role of Postgraduate Year 7 in Neurological Surgery Residency
Authors: Kolcun John Paul G. , Mazza Jacob M. , Pawlowski Kristen D. , Varela J. Roberto , Kolb Bradley , Traynelis Vincent C. , Byrne Richard W. , Fontes Ricardo B. V. 
Published: September 2023

BACKGROUND AND OBJECTIVES:
In 2013, all neurosurgery programs were mandated to adopt a 7-year structure. We sought to characterize how programs use the seventh year of training (postgraduate year 7 [PGY7]).

METHODS:
We surveyed all accredited neurosurgery programs in the United States regarding the PGY7 residents' primary role and the availability of enfolded fellowships. We compiled responses from different individuals in each program: chair, program director, program coordinator, and current chiefs.

RESULTS:
Of 120 accredited neurological surgery residency programs within the United States, 91 (76%) submitted responses. At these programs, the primary roles of the PGY7 were chief of service (COS, 71%), enfolded fellowships (EFF, 18%), transition to practice (10%), and elective time (1%). Most residencies have been 7-year programs for >10 years (52, 57%). Sixty-seven programs stated that they offer some form of EFF (73.6%). The most common EFFs were endovascular (57, 62.6%), spine (49, 53.9%), critical care (41, 45.1%), and functional (37, 40.7%). These were also the most common specialties listed as Committee on Advanced Subspecialty Training accredited by survey respondents. Spine and endovascular EFFs were most likely to be restricted to PGY7 (24.2% and 23.1%, respectively), followed by neuro-oncology (12, 13.2%). The most common EFFs reported as Committee on Advanced Subspecialty Training accredited but not restricted to PGY7 were endovascular (24, 26.4%) and critical care (23, 25.3%).

CONCLUSION:
Most accredited neurological surgery training programs use the COS as the primary PGY7 role. Programs younger in their PGY7 structure seem to maintain the traditional COS role. Those more established seem to be experimenting with various roles the PGY7 year can fill, including enfolded fellowships and transition-to-practice years, predominantly. Most programs offer some form of enfolded fellowship. This serves as a basis for characterization of how neurological surgery training may develop in years to come.
Intraoperative Closed Reduction of Traumatic Lateraloptosis: Operative Nuances
Authors: Powers Andrew Y. , Garcia Alfonso , Nwajei Felix , Binello Emanuela 
Published: September 2023

BACKGROUND AND IMPORTANCE:
Traumatic lateral spondyloptosis, or lateraloptosis, is the complete lateral dislocation of the spine. Reduction in these dislocations presents unique challenges, especially in cases of preserved neurological function. Open techniques carry significant risks of cerebrospinal fluid leak and neurological injury. For traditional spondyloptosis, off-table closed techniques have been described but may result in loss of the reduction when the patient is transferred to the operative table. An on-table closed reduction technique has potential advantages over previously described open reduction or off-table techniques for the treatment of lateraloptosis.

CLINICAL PRESENTATION:
The authors describe an on-table closed reduction technique for lateraloptosis, presenting an illustrative case in which the technique was applied. This technique is compared with alternative open and off-table reduction techniques described in the literature. The patient had good mechanical and neurological outcomes. At 14 months postoperatively, she is neurologically intact, back to work involving heavy lifting, and has only moderate back pain.

CONCLUSION:
On-table closed reduction before open fixation should be considered in cases of lateraloptosis, particularly when there is preserved neurological function.
Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer
Authors: Senguttuvan Rosemary N. , Santiago Nicole Lugo , Han Ernest S. , Lee Byrne , Lee Stephen , Lin Wei-Chien , Kebria Mehdi , Hakim Amy , Lin Jeff F. , Wakabayashi Mark T. , Ruel Nora , Tinsley Raechelle , Eng Melissa , Stewart Daphne B. , Wang Edward W. , Paz Benjamin I. , Wu Xiwei , Cho Hyejin , Liang Winnie S. , Rodriguez-Rodriguez Lorna , Cristea Mihaela C. , Raoof Mustafa , Dellinger Thanh H. 
Published: September 2023

Abstract
Purpose
Hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin confers a survival benefit in epithelial ovarian cancer (EOC) but is associated with renal toxicity. Sodium thiosulfate (ST) is used for nephroprotection for HIPEC with cisplatin, but standard HIPEC practices vary.

Methods
A prospective, nonrandomized, clinical trial evaluated safety outcomes of HIPEC with cisplatin 75 mg/m2 during cytoreductive surgery (CRS) in patients with EOC (n = 34) and endometrial cancer (n = 6). Twenty-one patients received no ST (nST), and 19 received ST. Adverse events (AEs) were reported according to CTCAE v.5.0. Serum creatinine (Cr) was collected preoperatively and postoperatively (Days 5–8). Progression-free survival (PFS) was followed. Normal peritoneum was biopsied before and after HIPEC for whole transcriptomic sequencing to identify RNAseq signatures correlating with AEs.

Results
Forty patients had HIPEC at the time of interval or secondary CRS. Renal toxicities in the nST group were 33% any grade AE and 9% grade 3 AEs. The ST group demonstrated no renal AEs. Median postoperative Cr in the nST group was 1.1 mg/dL and 0.5 mg/dL in the ST group (p = 0.0001). Median change in Cr from preoperative to postoperative levels were + 53% (nST) compared with − 9.6% (ST) (p = 0.003). PFS did not differ between the ST and nST groups in primary or recurrent EOC patients. Renal AEs were associated with downregulation of metabolic pathways and upregulation of immune pathways.

Conclusions
ST significantly reduces acute renal toxicity associated with HIPEC with cisplatin in ovarian cancer patients. As nephrotoxicity is high in HIPEC with cisplatin, nephroprotective agents should be considered.
Can a simulated window improve the ward environment? A survey of patient, carer and staff perspectives
Authors: Kawanishi Hideaki , Ida Mitsuru , Kaito Shinobu , Kimura Keiko , Kishimoto Asami , Onodera Hiroki , Kiriyama Takao , Sugie Kazuma , Kawaguchi Masahiko 
Published: September 2023

Background/Aims Simulated windows displaying images of the outside world can help to reduce emotional stress. This study investigated the effect of a simulated window on perceptions of the environment in a hospital ward among patients, family members, nurses and doctors. Methods A total of 48 participants (12 patients, 12 family members, 12 doctors and 12 nurses) were recruited from a four-bed patient room in a neurological ward in Japan. A 12-item questionnaire was administered, with participants rating their agreement with 11 statements about the room's simulated window on a 5-point Likert scale. The final item was a free-text question. Data were analysed using descriptive statistics. Results The majority of questionnaire items had average scores of 3–4, indicating neutral to moderately positive views of the simulated window. The majority of participants agreed that the window provided visual stimulation, but many did not see the benefits for communication or stress reduction. Qualitative feedback noted that they would prefer a simulated window that allowed patients to choose the image. Conclusions The simulated window was generally viewed positively or neutrally across participant groups, with feedback noting improvements to the technology that would lead to a better experience.
Diagnosis of periprosthetic joint infections in patients who have rheumatoid arthritis
Authors: Wang Yulai , Li Guoqing , Ji Baochao , Xu Boyong , Zhang Xiaogang , Maimaitiyiming Asihaerjiang , Cao Li 
Published: September 2023

AimsTo investigate the optimal thresholds and diagnostic efficacy of commonly used serological and synovial fluid detection indexes for diagnosing periprosthetic joint infection (PJI) in patients who have rheumatoid arthritis (RA).MethodsThe data from 348 patients who had RA or osteoarthritis (OA) and had previously undergone a total knee (TKA) and/or a total hip arthroplasty (THA) (including RA-PJI: 60 cases, RA-non-PJI: 80 cases; OA-PJI: 104 cases, OA-non-PJI: 104 cases) were retrospectively analyzed. A receiver operating characteristic curve was used to determine the optimal thresholds of the CRP, ESR, synovial fluid white blood cell count (WBC), and polymorphonuclear neutrophil percentage (PMN%) for diagnosing RA-PJI and OA-PJI. The diagnostic efficacy was evaluated by comparing the area under the curve (AUC) of each index and applying the results of the combined index diagnostic test.ResultsFor PJI prediction, the results of serological and synovial fluid indexes were different between the RA-PJI and OA-PJI groups. The optimal cutoff value of CRP for diagnosing RA-PJI was 12.5 mg/l, ESR was 39 mm/hour, synovial fluid WBC was 3,654/μl, and PMN% was 65.9%; and those of OA-PJI were 8.2 mg/l, 31 mm/hour, 2,673/μl, and 62.0%, respectively. In the RA-PJI group, the specificity (94.4%), positive predictive value (97.1%), and AUC (0.916) of synovial fluid WBC were higher than those of the other indexes. The optimal cutoff values of synovial fluid WBC and PMN% for diagnosing RA-PJI after THA were significantly higher than those of TKA. The specificity and positive predictive value of the combined index were 100%.ConclusionSerum inflammatory and synovial fluid indexes can be used for diagnosing RA-PJI, for which synovial fluid WBC is the best detection index. Combining multiple detection indexes can provide a reference basis for the early and accurate diagnosis of RA-PJI.Cite this article: Bone Joint Res 2023;12(9):559–570.
Osmotic pump with potential for bone lengthening distracts continuously in vitro and in vivo
Authors: Lippross Sebastian , Lorenz Heiko M. , Braunschweig Lena , Heede Andreas , Büscher Robin , Siegel Marlon , Schultheiß Gerhard , Vieten Sarah , Lüthje Annette , Matzen Andrea , Lüders Katja A. , Jäckle Katharina , Tsaknakis Konstantinos , Hell Anna K. 
Published: September 2023

Background
In pediatric orthopedics, long bone lengthening procedures are routinely performed using manual, motorized or magnetically controlled implants. This study aims to prove expansion of a newly designed osmotic pump prior to long bone lengthening in living organisms and to rule out any complications related to in vivo conditions, such as congestion of the semipermeable membrane, local infection, or lack of water to drive the osmotic pump, as well as to compare in vivo and in vitro expansion data.

Methods
Osmotic pumps, which were designed to distract a plate osteosynthesis, were inserted in the dorsal paraspinal musculature of four piglets. To compare the performance of the pumps in in vivo and in vitro conditions, another set of pumps was submerged in physiologic saline solution at different temperatures. The lengthening progress was measured radiographically and sonographically in the study animals.

Results
Both, in vitro and in vivo tested osmotic pumps started distraction after an intended rest phase of four days and distracted evenly over the following twelve days. No complications, clogging or damages occurred. However, we observed a temperature dependency of the distraction rate ranging from 0.98 mm/day at 39°C to 1.10 mm/day at 42°C. With a second setup, we confirmed that the distraction rate differed by 72% within a measured temperature interval of 14° C.

Conclusions
The data presented here confirm that the novel osmotic pump showed comparable lengthening characteristics in vivo and in vitro. No complications, such as congestion of the semipermeable membrane, local infection, or lack of water to drive the osmotic pump were observed. Thus, osmotic pumps may have great potential in future applications such as long bone lengthening procedures, where continuous distraction probably provides a better bone quality than intermittent lengthening procedures. The fact that one pump failed to elongate in each condition, highlights the importance of technical improvement, but also demonstrates that this was not due to different circumstances within the in vivo or in vitro condition.