bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Corrective Osteotomy of the Radius and Ulna for Mature Madelung Deformity Using CT-based 3D Simulation: A Case Report
Authors: KODAMA Akira , TANIMORO Kaguna , IWAGURO Shogo , ADACHI Nobuo 
Published: January 2023

We report a patient with mature Madelung deformity who underwent radial and ulnar corrective osteotomy using three-dimensional (3D) simulation. An osteotomy model was created using the computer-aided design (CAD) software based on the computed tomography (CT) data. After correcting the ulna, the osteotomy angle of the radius was determined using the location of the lunate as a landmark in the 3D plane created by the longitudinal axis of the corrected ulna. Consequently, the ulna was flexed 3° and shortened by 5 mm, and the radius was extended at 36° and ulna deviated at 25° by open wedge osteotomy. The radial inclinations, volar tilt and ulnar variance were 25°, 45° and 5 mm preoperatively, and improved to 22°, 10° and 0 mm after surgery. At the 18-month follow-up, the patient reported no pain even during sports activity. The preoperative 3D simulation enabled precise preoperative planning and accurate correction of the Madelung deformity. Level of Evidence: Level V (Therapeutic)
A New Toolbox for Scheduling Theory
Authors: Scully Ziv 
Published: January 2023

Queueing delays are ubiquitous in many domains, including computer systems, service systems, communication networks, supply chains, and transportation. Queueing and scheduling theory provide a rigorous basis for understanding how to reduce delays with scheduling, including evaluating policy performance and guiding policy design. Unfortunately, stateof- the-art theory fails to address many practical concerns. For example, scheduling theory seldom treats nontrivial preemption limitations, and there is very little theory for scheduling in multiserver queues.
My thesis presents two new, broadly applicable tools that greatly expand the reach of scheduling theory, using each to solve multiple open problems. The first tool, called "SOAP", is a new unifying theory of scheduling in single-server queues, specifically the M/G/1 model. SOAP characterizes the delay distribution of a broad space of policies, most of which have never been analyzed before. Such policies include the Gittins index policy, which minimizes mean delay in low-information settings, and many policies with preemption limitations. The second tool, called "WINE", is a new queueing identity that complements Little's law. WINE enables a new method of analyzing complex queueing systems by relating them to simpler systems. This results in the first delay bounds for Shortest Remaining Processing Time (SRPT) and the Gittins policy in multiserver queues, specifically the M/G/k model.
This abstract gives a brief overview of my thesis, describing what the SOAP and WINE tools do, the key ideas underlying them, and the open problems they help solve.
Multisensory Stimulation and Priming (MuSSAP) in 4-10 Months Old Infants with a Unilateral Brain Lesion: A Pilot Randomised Clinical Trial
Authors: Verhaegh Anke P. M. , Groen Brenda E. , Aarts Pauline B. M. , van Ee Raymond , Willemsen Michèl A. A. P. , Jongsma Marijtje L. A. , Nijhuis-van der Sanden Maria W. G. 
Published: January 2023

Aim. To explore the effect of an Early Intensive-Upper Limb intervention (EI-UL) compared to EI-UL with integrated Multisensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants with a unilateral brain lesion. Method. A pilot randomised clinical trial with pre- and postintervention and follow-up measurements (T0, T1, and T2) was conducted. Sixteen infants with a unilateral brain lesion (corrected age is 4-10 months) received home-based intervention with video coaching. Eight infants received EI-UL and eight infants received EI-UL with integrated MuSSAP training. Primary outcome was the Hand Assessment for Infants (HAI) score. Additionally, effects were explored on initiation of goal-directed movements in both groups and on attention in the EI-UL with integrated MuSSAP training group. Results. No significant group differences in HAI scores were found. Overall, HAI ‘Affected hand score’ increased between T0 and T1 (

p
=
0.001

,

Cohen
’
s

d
=
1.04

) and between T0 and T2 (

p
<
0.001

,

Cohen
’
s

d
=
1.28

); and the HAI ‘Both Hands Measure’ increased between T0 and T1 (

p
<
0.001

,

Cohen
’
s

d
=
1.72

) and between T0 and T2 (

p
<
0.001

,

Cohen
’
s

d
=
1.81

). At the start of the intervention, six infants (three in both groups) did not demonstrate initiation of goal-directed contralesional upper limb movements. During the intervention one infant receiving EI-UL and all three infants receiving EI-UL with integrated MuSSAP training started to initiate goal-directed movements. Conclusion. The results suggest manual ability of infants with unilateral brain lesion improved with both interventions. We hypothesize that the integrated MuSSAP training may facilitate attention and initiation of contralesional upper limb goal-directed movements. This trial is registered with NCT05533476).
QuantitativeIn VivoImaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response
Authors: Storey Claire M. , Altai Mohamed , Bicak Mesude , Veach Darren R. , Lückerath Katharina , Adrian Gabriel , McDevitt Michael R. , Kalidindi Teja , Park Julie E. , Herrmann Ken , Abou Diane , Zedan Wahed , Peekhaus Norbert , Klein Robert J. , Damoiseaux Robert , Larson Steven M. , Lilja Hans , Thorek Daniel , Ulmert David 
Published: January 2023

AbstractNoninvasive biomarkers for androgen receptor (AR) pathway activation are urgently needed to better monitor patient response to prostate cancer therapies. AR is a critical driver and mediator of resistance of prostate cancer but currently available noninvasive prostate cancer biomarkers to monitor AR activity are discordant with downstream AR pathway activity. External beam radiotherapy (EBRT) remains a common treatment for all stages of prostate cancer, and DNA damage induced by EBRT upregulates AR pathway activity to promote therapeutic resistance. [89Zr]11B6-PET is a novel modality targeting prostate-specific protein human kallikrein 2 (hK2), which is a surrogate biomarker for AR activity. Here, we studied whether [89Zr]11B6-PET can accurately assess EBRT-induced AR activity.Genetic and human prostate cancer mouse models received EBRT (2–50 Gy) and treatment response was monitored by [89Zr]11B6-PET/CT. Radiotracer uptake and expression of AR and AR target genes was quantified in resected tissue.EBRT increased AR pathway activity and [89Zr]11B6 uptake in LNCaP-AR and 22RV1 tumors. EBRT increased prostate-specific [89Zr]11B6 uptake in prostate cancer–bearing mice (Hi-Myc x Pb_KLK2) with no significant changes in uptake in healthy (Pb_KLK2) mice, and this correlated with hK2 protein levels.Implications:hK2 expression in prostate cancer tissue is a proxy of EBRT-induced AR activity that can noninvasively be detected using [89Zr]11B6-PET; further clinical evaluation of hK2-PET for monitoring response and development of resistance to EBRT in real time is warranted.
Students’ Resiliency towards Experiencing Tornado
Authors: Banal Ariel L. 
Published: January 2023

This study was conducted to find the meaning of resilience for students experiencing tornadoes. To attain the meaning of fear for a person with traumatic injury, to know the common effects of experiencing a tornado. To accomplish the reason for the study, the phenomenological method was used to comprehend and interpret the meaning of experiences of student's life when they experienced a tornado. The learners of one of the leading private schools in the Division of Pampanga-Philippines served as the informants of the study. Results revealed that the majority of the learners’ state that resiliency is a type of adaptability wherein they were able to adapt to the changes in their surroundings, on how they can stand regardless of what they have encountered, they were able to overcome it and that made them a resilient person. The researchers conducted an interview wherein most of their informants’ state that the fear and trauma they got from experiencing a tornado affects their lives. It can hinder someone from achieving their goals, they fear something they want to try because most of them state that it might happen again, it might cause them danger again, and they overthink just a wind that they think, another tornado will come again. When it comes to the effects of experiencing a tornado, most of them stated that they got scared and traumatized. Despite all the negative effects, tornados changed their perspective on life. It also recommended that parents and teachers provide comfort, counseling, and monitoring of learners' behavior.
Bartending: Knowledge, Attitude, and Practices among Bar Employees in Selected Resorts in Boracay Island
Authors: Gaviola Manuel A. , Maming Jimmy Bernabe 
Published: January 2023

This investigation aims determine the bartenders’ mindset, behaviors, and skills in mixing drinks on Boracay, a popular tourist attraction in the Philippines. The basic random sample approach was used to pick 98 bar personnel from various Boracay resorts as participants. During the data gathering, Domille (2013) Bartender's Test on Knowledge of Bartending as well as the TESDA Self-assessment Guide for the Certificate Program II were used, as well as probability, percentages, average, variance, t-test, one-way ANOVA, and Pearsons r. The interviewees were divided into groups as to their gender, age, socioeconomic status, education level, length of engagement, and monthly compensation. According to the findings, employees in Boracay Island are highly competent, have a positive mindset to bar work, and practice bartending extensively.
A Unicamp precisa falar sobre cotas: sujeitos, movimentos e disputas
Authors: Ribeiro Bruno Nzinga , Mesquita Tayná Victória de Lima , Lima Stephanie Pereira de 
Published: January 2023

No último decênio (2012-2022), vimos os resultados das primeiras experiências das cotas em universidades públicas, consolidadas pela lei n. 12.711 que instituiu a reserva de vagas em instituições federais de ensino superior. Paralelamente, acompanhamos uma grande resistência das universidades estaduais paulistas às cotas e a defesa de uma “inclusão por mérito”. Neste contexto, revisitamos as trajetórias do Núcleo de Consciência Negra da Unicamp (NCN), organização de estudantes negros que completa 10 anos de existência em 2022, a história do Núcleo de Estudos Negros (NEN), grupo pioneiro na ação coletiva de estudantes negros nos anos 2000, e o “Grupo de Estudos de Feminismos Negros”, iniciativa dos primeiros pós-graduandos cotistas, em 2016. Por fim, discutimos a luta pelas ações afirmativas na Unicamp, mais notadamente o processo de greve que culminou na criação das cotas raciais e do Vestibular Indígena, e a emergências de novas demandas e reivindicações de outros grupos sub-representados.
What Are Religious Hotspots? An Introduction
Authors: Fibiger Marianne Qvortrup 
Published: January 2023

Abstract
This introductory article outlines the meanings behind and the reasons for suggesting “religious hotspots” as a new analytical concept in the study of religion. The idea of suggesting this concept is not to replace others – for instance, a pilgrimage site, a religious place, a supernatural place, or a storied place – but to broaden the perspective and to emphasize the dynamic, multidimensional, and relational aspects of place, not least concerning how a religious place can be a hotspot for some and a cold one for others, but also how a place can change from being a hotspot to a cold spot and vice versa. Being a heated place, a religious hotspot can also have an unintended effect on people being there. They can either become “infected” by or “cured” of a feeling of religious or spiritual belonging. The concept is a contribution to the growing interest in space and place when analyzing religion, in recognition of how a landscape or a particular religiously legitimized site can be an important element in collective cultural, social, and political meaning-making.
Annotating cognates in phylogenetic studies of Southeast Asian languages
Authors: Wu Mei-Shin , List Johann-Mattis 
Published: January 2023

Abstract
Compounding and derivation are frequent in many language families. As a consequence, words in different languages are often only partially cognate, sharing some but not all morphemes. While partial cognates do not constitute a problem for the phonological reconstruction of individual morphemes, they are problematic for phylogenetic reconstruction based on comparative word lists. We review current practices of preparing cognate-coded word lists and develop new approaches that make the process of cognate annotation more transparent. Comparing four methods by which partial cognate judgments can be converted to cognate judgments for whole words on a newly annotated data set of 19 Chinese dialect varieties, we find that the choice of conversion method has an impact on the inferred tree topologies that cannot be ignored. We conclude that scholars should take great care with cognate judgments in languages in which compounding and derivation are frequent and recommend always assigning cognates transparently.
Comparing Perceptual Effects of Perspectival Convergence in Architectural Images
Authors: Han Eugene 
Published: January 2023

Abstract
This paper examines the correlation between vertical perspectival convergences in architectural images and their perception by monitoring the eye movements of subjects using eye tracking. Participants viewed images of buildings rendered in one of two variants, either with parallel or convergent vertical lines. In order to quantify differences of perception, a number of analyses were conducted, including density-based cluster analysis to determine areas of heightened visual regard, Voronoi subdivision which allowed for comparison of overall fixation areas, comparisons of fixation durations, image preference tests, and verbal comparisons. Eye-tracking recordings were analyzed in the aggregate in order to examine cumulative viewing behaviors. The study found that while differences in viewing behavior were evident within discrete image counterparts and various forms of analyses, perceptual trends regularly converged toward an even balance across testing stimuli. Attentional propensities tended to be guided by image features over the effects of mere perspectival registration.
The Mount Washington Observatory Regional Mesonet: A Technical Overview of a Mountain-Based Mesonet
Authors: Fitzgerald Brian J. , Broccolo J. , Garrett K. 
Published: January 2023

Abstract
The Mount Washington Observatory Regional Mesonet (MWRM) is a network of 18 remote meteorological monitoring stations (as of 2022), including the Auto Road Vertical Profile (ARVP), located across the White Mountains of northern New Hampshire. Each station measures temperature and relative humidity, with additional variables at many locations. All stations need to withstand the frequent combination of intense cold, high precipitation amounts, icing, and hurricane-force winds in a mountain environment. Due to these challenges, the MWRM employs rugged instrumentation, an innovative radio-communications relay approach, and carefully selected sites that balance ideal measuring environments with station survivability. Data collected from the MWRM are used operationally by forecasters (including Mount Washington Observatory and National Weather Service staff) to validate model guidance, by alpine and climate scientists, by recreationalists accessing conditions in the backcountry, by groups operating on the mountain (Cog Railway, toll Auto Road), and by search and rescue organizations. This paper provides a detailed description of the network, with emphasis on how the challenging climate and terrain of this mountain region impacts sensor selection, site maintenance, and overall operation.

Significance Statement
The mountain environment is a heterogeneous landscape, and interactions between the atmosphere and terrain can cause a wide variety of conditions across time and space. Our network of remote stations at different elevations across the White Mountains allows data users to understand how the weather varies spatially across the mountain range where conditions on higher peaks can be drastically, and dangerously, different. Sharing information about the MWRM can help other groups establish networks in similar challenging environments, and broaden our understanding of weather and climate in mountainous regions.
MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway
Authors: Zhang Wei , Zhang Qiu , Cui Qianbo , Xu Yu 
Published: January 2023

Background MicroRNA-3612 (miR-3612) is considered a tumor suppressor in different cancers. Nonetheless, its function in nasopharyngeal carcinoma (NPC) has yet to be uncovered. Methods NPC cells and tissues were tested by means of reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis and western blotting to quantify the expressions of miR-3612 and Thrombospondin 1 (THBS1). Cell Counting Kit-8 (CCK-8) and scratch experiments were carried out to evaluate the migration and proliferation of NPC cells. NPC cell adhesion was also assessed. The predicted interaction of miR-3612 with THBS1 was verified by means of a luciferase reporter assay. In vivo experiments were also conducted to examine how miR-3612 overexpression affects in vivo tumorigenicity. Lastly, phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway status was assessed via western blotting. Results MiR-3612 was downregulated in NPC cells and tissues, whereas THBS1 expression showed an opposite trend. The MiR-3612 mimic inhibited the NPC cell proliferation, adhesion, and migration and also inactivated the PI3K/AKT signaling pathway. Furthermore, miR-3612 mimic also hampered NPC tumorigenesis in vivo. MiR-3612 targeted THBS1 and downregulated THBS1 expression. THBS1 offset the miR-3612-overexpression-induced repression of the migration, adhesion, and proliferation of NPC cells via the activation of the PI3K/AKT pathway. Conclusion MiR-3612 retarded NPC cell migration, adhesion, and proliferation by targeting THBS1 and inactivating the PI3K/AKT signaling pathway. This provides a novel therapeutic approach for NPC intervention.
Mitogenic Effects of Brazilian Arthropod Venom on Isolated Islet Beta Cells: In Vitro Morphologic Ultrastructural and Functional Studies
Authors: Luca Giovanni , Calvitti Mario , Basta Giuseppe , Baroni Tiziano , Neri Luca M. , Becchetti Ennio , Capitani Silvano , Novaes Geovana , Correa-Giannella Maria Lucia , Kalapothakis Evanguedes , Engler Sylva Stuchi Maria , Eliaschewitz Freddy Goldberg , Sogayar Mari Cleide , Fanelli Carmine , Brunetti Paolo , Calafiore Riccardo 
Published: January 2023

Background One of the major pitfalls associated with use of isolated adult islets of Langerhans’ cells is their minimal mitotic capacity. Consequently, maintenance of a steady viable islet cell mass is very difficult. To explore how to enhance beta-cell mitogenesis, we have examined the effects of venom fractions extracted from a Brazilian scorpion on morphologic and functional beta-cell patterns. The venom was previously known to induce nesidioblastosis-like effects with chronic hypoglycemia and pancreatitis in animal models. Methods Venom fractions purified from Tityus bahiensis were incubated with batches of isolated rat islets, while a morphologic examination, glucose-stimulated insulin release, insulin content, and insulin messenger ribonucleic acid (mRNA) were carried out early during incubation. On fixation and double fluorescence immunolabeling (rhodamine for anti-insulin monoclonal antibodies; fluorescein for anti-5-bromodeoxyuridine), the preparations were imaged by confocal laser microscopy (CLM) for morphometric quantification of the mitoses. Insulin recovery and mRNA were also assessed at 21 days of culture. Results Under CLM examination, the beta-cell mitotic rate significantly rose from 1 to 12.8% for the venom-exposed islets. At day 7, insulin release and content were significantly lower for the venom-exposed than the control islets. However, at day 21 of culture, insulin release in response to static incubation with glucose and insulin mRNA from the venom-exposed islets was higher than controls ( p < .05). Conclusions Incubation with the scorpion venom induced a rapid and significant increase in the beta-cell proliferation not associated with a short-term increase in insulin secretion. The latter fully resumed and overcame controls later in culture, possibly after completion of the beta-cell expansion process.
Impact of Medical Student Research in the Development of Physician-Scientists
Authors: Solomon Solomon S. , Tom Stephen C. , Pichert James , Wasserman David , Powers Alvin C. 
Published: January 2023

Context A decline in the number of physician-scientists has been identified in the United States for at least two decades. Although many mechanisms have been proposed to reverse this trend, most of these have concentrated on MD/PhD programs, research in subspecialty fellowships, and other approaches later in physician training. Few have emphasized early medical student research experiences as a contributing solution. Objective To determine the effect of a medical student research experience on career choices and attitudes about biomedical research. Design, Setting, and Participants We jointly report 25 years of experience with National Institutes of Health (NIH)-sponsored Medical Student Research Fellowship programs (MSRFs) at two colleges of medicine, the University of Tennessee Health Science Center and Vanderbilt University. In both programs, students work during the summer of their first or second year of medical school on a research project that is mentored by an established scientist and participate in a structured program (lectures, visiting professor). Main Outcome Measures We gathered data using pre- and postresearch fellowship questionnaires to assess (a) quality of research experiences; (b) tabulation of productivity, that is, presentations, abstracts, publications, and awards; (c) long-term tracking of former program participants; (d) comparison of residency placements by medical student researchers; and (e) comments from former program participants on the effects of their students’ research experiences on career choices. Results During this time, approximately 1,000 medical students participated in the two programs. Follow-up data (for short-term evaluations, 96–132 respondents with a response rate > 82%; for long-term evaluations, 88–118 respondents with a response rate > 29–33%) strongly suggest (a) interest in an academic career increased, (b) one-third to half of former student respondents considered themselves to be in academic medicine, (c) the vast majority of students conducted additional research after their medical student research experience, and (d) a large number of students were currently doing research or had published or presented their work at scientific meetings. Conclusions Over two decades of experience with NIH-sponsored medical student research programs at two medical schools strongly support the ability of these programs to interest medical students in research and academic careers. MSRFs should be included in strategies to reverse the decline in the number of physician-scientists.