bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and impacts of climate change on crop production in Burkina Faso
Authors: Sanou Charles Lamoussa , Neya Oblé , Agodzo Sampson Kwaku , Antwi-Agyei Philip , Bessah Enoch , Belem Mahamadou , Balima Larba Hubert 
Published: July 2023

Abstract

Understanding past climate trends and their impacts in the Sahel region is fundamental for climate change (CC) adaptation and mitigation. This study analyses climate trends from 1961 to 2020 in three climatic zones in Burkina Faso and the impacts of CC on five major crops production. Long time series of daily rainfall and temperature data from National Meteorology Agency for the period 1961 to 2020 has been compiled. Crop production data (1984–2020) were retrieved from the agriculture department. Climate temporal variations in each climatic zone were analyzed using extreme climate indices and principal component analysis. Linear regression was used to assess climate impacts on crop production. The results showed a high rainfall variability and changes in temperature extremes in the three zones. The climate window, 1991–2020, was hotter than 1961–1990, while the last decade (2011–2020) was the wettest. Most climate indices (67%) showed significant correlations with crop yields. Dry spells, cool days, cold nights, average daily wet days and rainfall intensity showed positive and negative effects on maize, cowpea, millet and sorghum yields. This study highlights the importance of climate-smart policy promoting drought-resistant and short-duration varieties in addressing the adverse effects of CC on crop production.
Gradient-Boosted Decision Tree with used Slime Mould Algorithm (SMA) for wastewater treatment systems
Authors: Chauhan Jyoti , Rani R. M. , Prashanthi Vempaty , Almujibah Hamad , Alshahri Abdullah , Rao Koppula Srinivas , Radhakrishnan Arun 
Published: July 2023

Abstract
One way to improve the infrastructure, operations, monitoring, maintenance, and management of wastewater treatment systems is to use machine learning modelling to make smart forecasting, tracking, and failure prediction systems. This method aims to use industry data to treat the wastewater treatment model. Gradient-Boosted Decision Tree (GBDT) algorithms were used gradually to predict wastewater plant parameters. In addition, we used the Slime Mould Algorithm (SMA) for feature extraction and other acceptable tuning procedures. The input and effluent Chemical Oxygen Demand (COD) prediction for effluent treatment systems applies to the GBDT approaches employed in this study. GBDT-SMA employs artificial intelligence to provide precise method modelling for complex systems. Several training and model testing techniques were used to determine the best topology for the neural network models and decision trees. The GBDT-SMA model performed best across all methods. With 500 data, GBDT-SMA achieved an accuracy of 96.32%, outperforming other models like Artificial Neural Network (ANN), Convolutional Neural Network (CNN), Deep Convolutional Neural Network (DCNN), and K-neighbours RF, which reached an accuracy of 82.97, 87.45, 85.98, and 91.45%, respectively.
The Role of CDK20 Protein in Carcinogenesis
Authors: Chivukula Sowmya , Malkhed Vasavi 
Published: July 2023

Abstract:
Cancer is a complex disease that develops when abnormal cells divide uncontrollably as
a consequence of unregulated cell cycle protein activity. Therefore, the cell cycle is crucial for
maintaining homeostasis inside the cells during DNA replication and cell division. The presence of
mutations within specific genes can disrupt the equilibrium within cells, ultimately leading to the
growth of cancer. CDK20 (Cyclin-Dependent Kinase 20) is recently identified as a major controller
of cell cycle checkpoints, which regulate cell growth and proliferation and perform a role in
the development of many malignancies. CCRK (Cell-Cycle Related Kinase) has recently been renamed
CDK20. Emerging studies proclaimed that the upregulation of CDK20 was identified in cancers
of the ovary, brain, colon, stomach, liver, and lung. CDK20 was thought to have Cyclin-dependent
activating kinase (CAK) activity for CDK2 when it is complexed with Cyclin H. Furthermore,
recent studies revealed that CDK20 is involved in the Wnt, EZH2/NF-B, and KEAP1-NRF2 signaling
pathways, all of which are interconnected to cancer formation and proliferation. In addition, the
structure of CDK20 was predicted using ColabFold, a powerful software integrating AlphaFold's
advanced AI system. The present review focuses on a systematic overview of the current knowledge
on CDK20 derived from in vitro and in vivo studies and emphasizes its role in carcinogenesis.
The validation comparison of the existing CDK20 AlphaFold structure with the ColabFold was
found to be exceptionally fast and accurate in generating reliable models.
Enhancing Economic Management with Information Technology: Insights from Covid-19 in Bosnia and Herzegovina Through the Lens of Machine Learning Methods
Authors: Salkić Hadžib , Omerović Aldijana , Salkić Almira , Kvasina Marija 
Published: July 2023

Abstract
This paper explores the role of information technology in enhancing the efficiency of economic management during the COVID-19 pandemic. The research aim was to investigate how the integration of information technology, data usage, and analytics, digital transformation of the financial sector, ensuring digital inclusion and cyber security can contribute to improving economic management in times of crisis. The research methodology involved data collection through a questionnaire that asked participants a series of questions about their attitudes and perceptions regarding the integration of information technology and its impact on the efficiency of economic management during the pandemic. The data were analyzed using the chi-square statistical method to determine the existence of significant relationships between variables. The results indicate that information technology is a key factor in strengthening economic management during the COVID-19 pandemic. The integration of information technology, data usage, and analytics, digital transformation of the financial sector, and ensuring digital inclusion and cyber security can enhance efficiency, transparency, and stability during crisis times. The research emphasizes the need for investment in information technology, the development of implementation strategies, strengthening cyber security, and ensuring digital inclusion as key steps towards building a more resilient economic environment during the pandemic. Further research and implementation of these technologies in practice are recommended to achieve sustainable economic development and successful crisis management.
The Migration Crisis in the European Union and the Postponement of Romania’s Accession to the Schengen Area
Authors: Boicean Danusia , Morar Lucia-Larissa 
Published: July 2023

Abstract
The current major challenge facing the European Union is the phenomenon of migration, with its deep-rooted causes, illegal migration routes, and socio-economic consequences being highly topical issues that require strong interventions, as they bring to the forefront not only inherent costs but also the criminality that accompanies this phenomenon. At the last EU Council meeting for Justice and Home Affairs in December 2022, the admission of Croatia to the Schengen area was approved, while surprisingly, Romania and Bulgaria were rejected. In this context, it is of great interest to analyze the real dimension and concern surrounding the migration phenomenon that led to Austria’s vote against Romania, even though analyzed data presents a different situation, indicating that Bulgaria and Croatia are among the main transit countries, while Romania is only secondary. However, the real problem Austria is facing is a common challenge that must be addressed by the European Union through cooperation between the three categories of countries involved: member states, transit countries, and countries of origin.
The Role of Operational Law in the Development of Military Doctrine
Authors: Guţan Sabin 
Published: July 2023

Abstract
This article is focused on studying the emergence and evolution of operational law as a support for the planning and conducting of military operations in times of peace and war. Issues regarding its curricular area, differences with international humanitarian law, how it can support the evolution of military doctrine and science are addressed. In this context, I analyse the case of the implementation of operational law in the USA, following the military failure in Vietnam, and its role in the reformation of American military doctrine. Finally, I analyse the new reform of the American military law system, the transition from operational law to national security law, triggered by the multiplication of armed threats and the emergence of new types of military actions and battle spaces (especially hybrid warfare, information warfare and cyber warfare). I also analyse the importance of implementing operational law within the Romanian army and the benefits for the evolution of Romanian military doctrine.
Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing
Authors: Alasmari Fawaz , Alasmari Mohammed S. , Muwainea Hussa Mubarak , Alomar Hatun A. , Alasmari Abdullah F. , Alsanea Sary , Alshamsan Aws , Rasool Muhammad F. , Alqahtani Faleh 
Published: July 2023

Introduction: Ceftriaxone is one of commonly prescribed beta-lactam antibiotics with several label and off-label clinical indications. A high fraction of administered dose of ceftriaxone is excreted renally in an unchanged form, and it may accumulate significantly in patients with impaired renal functions, which may lead to toxicity.Methods: In this study, we employed a physiologically-based pharmacokinetic (PBPK) modeling, as a tool for precision dosing, to predict the biological exposure of ceftriaxone in a virtually-constructed healthy and chronic kidney disease patient populations, with subsequent dosing optimizations. We started developing the model by integrating the physicochemical properties of the drug with biological system information in a PBPK software platform. A PBPK model in an adult healthy population was developed and evaluated visually and numerically with respect to experimental pharmacokinetic data. The model performance was evaluated based on the fold error criteria of the predicted and reported values for different pharmacokinetic parameters. Then, the model was applied to predict drug exposure in CKD patient populations with various degrees of severity.Results: The developed PBPK model was able to precisely describe the pharmacokinetic behavior of ceftriaxone in adult healthy population and in mild, moderate, and severe CKD patient populations. Decreasing the dose by approximately 25% in mild and 50% in moderate to severe renal disease provided a comparable exposure to the healthy population. Based on the simulation of multiple dosing regimens in severe CKD population, it has been found that accumulation of 2 g every 24 h is lower than the accumulation of 1 g every 12 h dosing regimen.Discussion: In this study, the observed concentration time profiles and pharmacokinetic parameters for ceftriaxone were successfully reproduced by the developed PBPK model and it has been shown that PBPK modeling can be used as a tool for precision dosing to suggest treatment regimens in population with renal impairment.
The effect of group art therapy on acculturative and academic stress of Chinese graduate students in South Korea
Authors: Yin Yue , Ko Kyung Soon 
Published: July 2023

BackgroundResearch has shown that international students, specifically Chinese graduate students in South Korea, are vulnerable to stress and depression because of various factors. These include environmental changes, economic constraints, interpersonal difficulties, discrimination, and cultural conflict.ObjectiveThis study investigates the effectiveness of group art therapy in reducing acculturative stress and academic stress among Chinese graduate students in South Korea.MethodThirty participants were recruited and randomly assigned to the experimental (n = 15) and control groups (n = 15). The experimental group received eight 120-min sessions of group art therapy. Both groups were tested for acculturative stress (perceived discrimination, homesickness, perceived hate, fear, stress due to change/culture shock) and academic stress (schoolwork stress, future stress, social stress, living environment stress) before and after the art therapy intervention. Results were compared using the Mann–Whitney U test and the Wilcoxon signed-rank test.ResultsThe results showed that there was a significantly greater reduction in acculturative and academic stress in the experimental than the control group.ConclusionGroup art therapy can provide psychological and emotional support to international students studying abroad.
Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells
Authors: Caballero-Gallardo Karina , Alvarez-Ortega Neda , Olivero-Verbel Jesus 
Published: July 2023

The utilization of plants with medicinal properties is deeply rooted in the traditional knowledge of diverse human populations. This study aims to investigate the cytotoxicity of nine plants commonly used by communities in San Basilio de Palenque, Bolivar (Colombia), for managing inflammation-related illnesses. Hydroethanolic extracts from various plant parts such as roots, stems, barks, or leaves were prepared through a process involving drying, powdering, and maceration in an ethanol–water (7:3) solution. The extracts were subsequently freeze-dried and dissolved in DMSO for the bioassays. Cytotoxicity against the human hepatoma HepG2 cell line was assessed using the MTT assay, with extract concentrations ranging from 0 to 500 µg/mL and treatment durations of 24 and 48 h. The total phenolic content of the nine extracts varied from 96.7 to 167.6 mg GAE/g DT. Among them, eight hydroethanolic extracts from Jatropha gossypiifolia L., Piper peltatum L., Malachra alceifolia, Verbesina turbacensis, Ricinus communis, Desmodium incanum, and Dolichandra unguis-cati showed low toxicity (IC50 > 500 µg/mL, 24 h) against HepG2 cells. On the other hand, the extracts of Aristolochia odoratissima L. (IC50 = 95.7 µg/mL) and Picramnia latifolia (IC50 = 128.9 µg/mL) demonstrated the highest cytotoxicity against the HepG2 cell line, displaying a modest selectivity index when compared to the HEKn cell line after 48 h of treatment. These findings suggest that medicinal plants from San Basilio de Palenque, particularly Picramnia latifolia and Aristolochia odoratissima, have potential activity against cancer cells, highlighting their potential for further research and development.
The problem of primary infection in endo-periodontal lesions: a systematic review
Authors: Moiseev D. A. , Kopetsky I. S. , Nikolskaya I. A. , Ilyukhin G. S. , Gazarov S. Yu. , Madatyan G. K. , Sevastyanova V. V. , Kurbatina A. B. 
Published: July 2023

The main ways of interrelation of pulp and periodontal tissues are normally the apical openings of the roots of the teeth and additional root canals. In addition, it is important to remember that the bulk of the tooth is dentin, permeated with the smallest dentine tubules, which can also serve as a road in the «endodont-periodontal» system. A doctor who is faced with endo-periodontal lesion (EPL) faces a difficult task, which consists in competent planning of complex treatment and predicting the patient's condition. And one of the main questions that a clinician needs to answer when planning effective prevention and treatment of EPL is «What is primary? ». This systematic review is devoted to the problem of the primacy of infection in EPL, as the most complex and poorly studied.Aim. To summarize the available data on the features of the etiology, pathogenesis, diagnosis and clinical course of EPL.Materials and methods. 3587 publications were found, presented in international lectronic databases: PubMed, Google Search, Ebsco, Embase, Web of Science, ScienceDirect, SciELO and eLibrary from 2000 to 2023. Based on the selection criteria, 65 publications were selected, which included the results of studying the structure of periodontal tissues and tooth pulp, etiology, pathogenesis, as well as the diagnosis and clinical course of EPL. The methodology of this study meets the requirements for systematic reviews and meta-analyses of «PRISMA».Results. The features of pulpo-periodontal relationships are described, data on the prevalence and classification of EPL are presented. Special attention is paid to the etiology of EPL and possible infectious agents involved in the pathogenesis of EPL. The clinical and diagnostic features of the course of EPL and the main approaches to treatment, depending on the primary infection of tissues, are described.Conclusions. The presented detailed systematic analysis showed that the problem of EPL, which has high relevance and significance, has not been studied enough, which does not allow to effectively diagnose, treat, prevent and predict this pathology.
Systematization of the routing scheme of patients with diseases of the mucosa of the mouth
Authors: Shkarin V. V. , Poroyskiy S. V. , Makedonova Yu. A. , Emelyanova O. S. , Bolovina Y. P. , Dyachenko S. V. 
Published: July 2023

The problem of the effectiveness of monitoring and routing of patients with diseases of the oral mucosa is relevant.Aim. To supplement and systematize the route scheme for patients with diseases of the oral mucosa using telemedicine technologies, depending on the level of the medical organization.Materials and methods. Supplementation and systematization, as well as a clinical study of an optimized three-stage routing scheme, were carried out. The study involved 32 patients who applied to dental medical organizations of the 1st level, 36 patients observed in the 2nd level of the MD, 46 patients from the 3rd level of the MD.Results and discussion. when monitoring the course of inflammatory and destructive diseases of the oral mucosa in patients observed at the place of residence, a positive trend was revealed, however, 38 patients, due to treatment failure, according to the routing scheme, were referred to dental clinics. level 3 organizations, where the clinical stabilization of the process was achieved with the use of digital methods of monitoring and treatment.Conclusions: a comparative clinical study identified the need for a routing scheme to improve the quality of dental care at the level of dental health of patients with diseases of the oral mucosa.
Comparative analysis of the measurement parameters of the palatine tonsils according to LC and CBCT data
Authors: Balashova M. E. , Khabadze Z. S. , Popadyuk V. I. 
Published: July 2023

The palatine tonsils hypertrophy can cause the development of oral breathing, obstructive sleep apnea, malocclusion, especially in children. Early diagnosis and treatment of ENT pathology is important to reduce the frequency of dental and general pathologies.Aim. To evaluate the measurements of the palatine tonsils by LC and CBCT and compare the effectiveness of these methods.Materials and methods. In 10 patients aged 10-12 years with enlarged palatine tonsils, according to ENT history, CBCT were performed, LC reformates were formed. The clinical efficacy and limitations applied method and correlation between the area and volume of the tonsils were evaluated.Results. The difference in tonsils size according to 2D and 3D methods was not statistically significant. However, СBCT allows to visualize the bounders better, to evaluate the tonsils from both sides, excluding the superimposition of soft tissue contours (soft palate, tongue) and bone structure (mandibular angle).Conclusions. The results show that linear measurements of the tonsils are reliable since there is a positive correlation with the corresponding sagittal parameters on 2D and 3D data. Accurate determination of the palatine tonsils size in a patient by lateral cephalography is difficult due to the large variability of the three-dimensional structure of the upper airway. Therefore, CBCT is a more accurate method in diagnosis tonsils.
Influence of geometrical parameters of dental implants on secondary stability and osseointegration process depending on the type of bone
Authors: Studenikin R. V. , Sushchenko A. V. , Mamedov A. A. 
Published: July 2023

Aim. Comparison of the secondary stability and osseointegration rate of dental implants with fine and coarse threads placed in bones of various types.Materials and Methods. The study considered the data of 60 implants with fine and coarse threads, installed in the bone types I-III. After two and six months, an analysis of the loss of marginal bone, micromotion tests were carried out, changes in the stability coefficients were determined by the method of frequency magnetic resonance.Results. The 30 coarse threaded implants showed higher secondary stability compared to the finely threaded implants in all three bone types. Marginal bone loss was observed for both types of implants only in type III bone – but when comparing the absolute values, it is noticeable that they are smaller with large threads. Micromotion was absent in all cases for bone types I and II. For implants with large threads in type III bone, micromotion was less than 30 μm, and for implants with fine threads, it was 150-160 μm.Conclusions. High secondary stability is typical for implants installed in type I-II bone, regardless of the thread pitch, but the value of the stability coefficient is higher for specimens with coarse threads. In addition, there is no loss of marginal bone in these cases. Finely threaded implants placed in Type III bone are subject to micromovement.
Evaluation of the quality of medical documentation according to retrospective analysis
Authors: Korchagina M. S. , Postnikov M. A. , Burda G. K. , Simanovska O. E. , Ratnikova A. S. 
Published: July 2023

As a result of a retrospective analysis of medical records in private dental organizations in the cities of Samara and Ulyanovsk was analyzed the quality of medical records, compliance with approved standards and clinical treatment protocols.Aim. To assess the quality of specialized dental care for patients with chronic forms of pulpitis.Materials and Methods. 2484 medical records were analyzed and 840 patients with chronic forms of pulpitis were identified. An analysis of the structure of and prevalence of the disease was carried out.Results. 840 patients were diagnosed with chronic pulpitis in 1412 teeth, the most common form of the disease was established. The prevalence of various forms of chronic pulpitis according to the classification of Moscow State Medical University was estimated based on the classification of E.E. Platonov (1968). This classification was the most common when making a diagnosed by dentistsConclusions. The main age group of patients with chronic forms of pulpitis, the predominant sex of patients, the most common form of chronic pulpitis, and established which groups of teeth are most often affected. An analysis of the filed of medical records of dental patients with chronic forms of pulpitis was made.