bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Social Determinants of Health in Pediatric Shunted Hydrocephalus
Authors: Khalid Syed I. , Hunter Brittany M. , Shah Pal , Patel Aashka , Thomson Kyle B. , LoPresti Melissa A. , Roblin Douglas W. , Lam Sandi , Mehta Ankit I. 
Published: February 2023

BACKGROUND:
Social risk factors have been shown to negatively affect health outcomes in children. However, this has not been characterized regarding pediatric shunted hydrocephalus.

OBJECTIVE:
To explore the impact of social risk factors on outcomes in pediatric shunted hydrocephalus with the goal of identifying specific areas of intervention that might improve the outcomes of children undergoing cerebrospinal fluid (CSF) diversion.

METHODS:
In an all-payer administrative database, records between January 2010 and October 2020 were analyzed to identify children undergoing CSF shunting procedures. Children with social risk factors were compared with those without regarding rates of infection, shunt-related interventions, and mortality within 5 years of their shunting procedure.

RESULTS:
Among the 5420 children who underwent first-time shunting procedures, 263 (4.9%) were identified to have social risk factors. Children with identified social risk factors had increased odds of central nervous system infection (odds ratio [OR] 2.06, 95% CI 1.45-2.91), revision (OR 2.43, 95% I 1.89-3.12), and mortality (OR 2.86, 95% CI 1.23-5.72). The mean numbers of computed tomography studies (14.60 ± 17.78 vs 6.34 ± 6.10), MRI studies (18.76 ± 24.37 vs 7.88 ± 24.37), and shunt series X-rays (17.22 ± 19.04 vs 7.66 ± 8.54) were increased among children with social risk factors.

CONCLUSION:
Children with social risk factors had increased rates of central nervous system infection, shunt-related interventions, and mortality within 5 years of CSF shunting. We underscore the importance of characterizing the impact of social risk factors in specific conditions, such as pediatric shunted hydrocephalus, and look to future directions aimed to mitigate these risk factors with coordination and direction of individualized resources, encouragement of advocacy, and community partnership.
Comparison of the antimicrobial reduction effect of photodynamic inactivation with the addition of chlorophyll and curcumin photosensitizer in Aggregatibacter actinomycetemcomitans and Enterococcus faecalis
Authors: Arifianto Deny , Astuti Suryani Dyah , Medyaz Sarah Ratri , Lestari Septia Budi , Samian Samian , Nurdin Dezy Zahrotul Istiqomah , Hariyani Dita Ayu , Susilo Yunus , Syahrom Ardiansyah 
Published: February 2023

Background: Aggregatibacter actinomycetemcomitans and Enterococcus faecalis are pathogenic bacteria of the oral cavity that cause various diseases such as periodontitis and endodontics. These bacteria are easily resistant to antibiotics. Photodynamic inactivation (PDI) is a method of inactivating microorganisms that utilizes light to activate a photosensitizer agent (PS) that produces reactive oxygen species causing cell lysis. Methods: This study used the PDI method with a 405 nm diode laser at various energy density with the addition PS curcumin or chlorophyll Alfalfa, as much as 1.6 mg/ml on A. actinomycetemcomitans and E. faecalis bacteria. Results: The study on E. faecalis bacteria showed that the energy density diode laser irradiation of 1.59 J/cm² gave the percentage of E. faecalis bacteria death 36.7% without PS, 69.30% with the addition of chlorophyll Medicago sativa L and 89.42% with the addition of curcumin. Meanwhile, the bacteria A. actinomycetemcomitans showed that the energy density diode laser irradiation of 1.59 J/cm² gave the percentage of bacterial death 35.81% without PS, 64.39% with the addition of chlorophyll Medicago sativa L and 89.82% with the addition of curcumin. PS was critical to the success of the PDI. Conclusions: The addition of PS curcumin increased the effectiveness of reducing bacteria E. faecalis and A. actinomycetemcomitans compared to chlorophyll Medicago sativa L.
Case Report: COVID-19 with cytokine storm in a 16-year-old patient: if heart failures comes think about levosimendan
Authors: Rodriguez-Garcia Veronica , Guerrero Orriach Jose Luis , Ariza Villanueva Daniel , Garcia Pinilla Jose Manuel , Robles Mezcua Ainhoa , Rubio Navarro Manuel , Cruz Mañas Jose 
Published: February 2023

Introduction: Our case is unique because the differential diagnosis was a challenge. At first, the patient presented with septic shock and multi-organ failure in the context of a suspected lymphoproliferative syndrome. Once the lymphoproliferative process had been ruled out, hemophagocytic syndrome due to COVID-19 infection was suspected, so he is probably one of the few patients with such an exhaustive study that could contribute to our understanding of COVID-19. We followed therapeutic guidelines that differ from the usual, using adrenalin and levosimendan. Corticosteroids helped to modulate the cytokine storm. Case report: A 16-year-old adolescent was admitted to the intensive care unit with fever, diarrhea, multiorgan failure and septic shock. He was IgG positive for COVID-19 and IgM negative. Thoraco-abdominal computed tomography demonstrated multiple para-aortic and peri-pancreatic lymphadenopathy and acute respiratory distress syndrome. The first suspected diagnosis was a lymphoproliferative syndrome and bacterial infection. The second possibility was a hemophagocytic syndrome in a patient recovering from COVID-19. He was treated with broad spectrum antibiotics because the differential diagnosis was difficult, and we removed them when the microbiological screening was negative. During the course of the disease he presented with severe biventricular dysfunction, probably due to the cytokine storm, so we used inotropic drugs (adrenaline, levosimendan). Infection with Salmonella species group B was diagnosed later, when the patient was in the Internal Medicine ward, although he was asymptomatic. Conclusion: The severity of COVID-19 infection ranges from mild to severe, causing serious disease in some people. Although the pathophysiology is not well known, it seems that in some cases an immune storm is triggered, and it is related to more serious and prolonged disease. In our case, heart failure was important, because it could have worsened the prognosis. Fortunately, the response to levosimendan and corticosteroids was adequate and he recovered favorably until discharge.
Mutation spectrum analysis of DMD gene in Indonesian Duchenne and Becker muscular dystrophy patients
Authors: Dwianingsih Ery Kus , Iskandar Kristy , Hapsara Sunartini , Ping Liu Chun , Malueka Rusdy Ghazali , Gunadi . , Matsuo Masafumi , Lai Poh San 
Published: February 2023

Background: Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are allelic disorders caused by mutations in the DMD gene. The full mutation spectrum of the DMD gene in Indonesian patients is currently unknown. Mutation-specific therapies are currently being developed, such as exon skipping or stop codon read-through therapy. This study was conducted with the aim of identifying the mutation spectrum of the DMD gene in Indonesia to guide future development and application of feasible therapeutic strategies. Methods: This study is a cross sectional study that enrolled 43 male patients with a clinical suspicion of DMD or BMD. Multiplex ligation-dependent probe amplification (MLPA) reaction was performed to screen for the common mutations in the DMD gene. Results: Out of 43 subjects, deletions accounted for 69.77% (n=30) cases, while duplications were found in 11.63% (n=5) cases. One novel duplication spanning exons 2 to 62 was identified. Deletion mutations clustered around the distal (66.67%) and proximal (26.67%) hot spot regions of the DMD gene while duplication mutations were observed solely at the proximal region. Two false positive cases of single exon deletion detected through MLPA were attributed to sequence mutations affecting primer ligation sites, confirming the need to validate all single exon deletions when using this screening method. Analysis of available maternal DNA samples showed that the rate of de novo mutations (48.15%) appears higher than expected in this population. Out of 31 patients who were classified as DMD based on clinical and genotype characterizations, 60.47% (n=26) of cases were suitable for exon skipping therapy. Conclusion: This is the first comprehensive study showing the feasibility of implementing the MLPA method for routine screening of DMD patients in Indonesia. This is also the first study showing the potential applicability of exon skipping therapy in the majority of DMD cases in the country.
12 tips for introducing e-portfolios in undergraduate medical and dental curriculums
Authors: Javed Kainat , Arooj Mahwish , Ashraf Rizwan , Kaukab Nabila , Khan Rehan Ahmed 
Published: February 2023

It is impossible to overlook the curricular advancements occurring all across the world. The evaluation methods should be revised in addition to the course objectives, programmes, and competences. If courses are evaluated the same way they have been in the past, we will not progress in education. We are on the verge of an educational revolution that will fundamentally alter how we educate and assess students. E-portfolios have now become recognized and valued by everyone in medical education and the workplace, including policymakers. For programmatic assessments, E-portfolios are the best supporting document one can use as a qualitative assessment. It can be used in many ways including career planning, assessment, and for structured feedback. E-Portfolio provides a secured database and then there are numerous ways to use this knowledge. It allows a learner to gather and exhibit proof of their accomplishments and proficiency in order to support the modern techniques of academic assessment. In this article, we suggest 12 tips for putting a portfolio programme for undergraduate students into practice. The suggestions are based on an extensive evaluation of the literature, and the authors' personal experiences helped lay the groundwork for the recommendations.
Implementation of noise-reduction strategies and designated quiet time in an intensive care unit
Authors: Gupta Poonam , Thomas Mincy , Amer Aisha , Joseph Sherin , Louis Ivy , George Jacinth , Al Zubi Mohammad , Mcdonald Ian , El Hassan Mawahib 
Published: February 2023

Background/Aims Excessive noise is a considerable problem in intensive care units, interfering with patient rest, recovery times and patient satisfaction. This quality improvement project aimed to implement and evaluate noise-reduction strategies in a coronary intensive care unit in Doha, Qatar. Methods Rapid plan-do-study-act cycles were used to implement several noise reduction strategies, including the introduction of two designated quiet time periods per day (15:00–16:00 and 2:00–4:00), staff education about the impact of noise, environmental adjustments and an audio-visual device to alert staff, patients and visitors of excessive noise levels. A sound metre app was used to measure noise levels for 4 months before the intervention and for nearly 3 years (April 2018–December 2020) after implementation. Surveys were used to collect informal feedback from staff and patients on the ward. Results The average pre-intervention noise level on the unit were 64.6 dB, which was reduced to a consistent average of 24 dB during designated quiet times following the interventions. No adverse effects on communication or medical errors were observed. Patient and staff feedback was positive, with most patients (n=50) and all staff (n=86) being satisifed with the noise levels following the intervention. Conclusions Although the nature of activity in intensive care units makes them noisy environments, it is possible to reduce noise levels by targeting modifiable factors and implementing simple measures, such as dedicated quiet times, staff education and audio-visual noise alerts.
Impact of COVID-19 pandemic on utilization of essential maternal healthcare services in Ethiopia: A systematic review and meta-analysis
Authors: Mekonnen Birye Dessalegn , Yirdaw Berhanu Wale 
Published: February 2023

BackgroundThe COVID-19 pandemic has a significant challenge for countries to maintain the provision of essential maternity services. Many women could experience difficulties in accessing maternal healthcare due to transport problems, anxiety, and fear of infection. A reduction in the utilization of maternity services has been suggested as a possible cause of worsened maternal health outcomes. Thus, this study aimed to determine the impact of the COVID-19 pandemic on the utilization of maternal healthcare services in Ethiopia.MethodsSearching of articles was conducted from PubMed, Science Direct, Cochrane Library, Web of Science, Scopus, and Google scholar. The quality of studies was evaluated using the Newcastle-Ottawa scale. Inspection of the Funnel plot and Egger’s test were used to evaluate the evidence of publication bias. Heterogeneity was evaluated using Cochran’s Q statistic and quantified by I2. A random-effects model was used to determine pooled estimates using STATA 14.ResultsAfter reviewing 41,188 articles, 21 studies were included in this systematic review and meta-analysis. The pooled reduction was 26.62% (95% CI: 13.86, 39.37) for family planning, 19.30% (95% CI: 15.85, 22.76) for antenatal care, 12.82% (95% CI: 7.29, 18.34) for institutional delivery, 17.82% (95% CI: 8.32, 27.32) for postnatal care, and 19.39% (95% CI: 11.29, 27.49) for abortion care. This study also demonstrated that maternal perception of poor quality of care and fear of infection, lack of transport, cultural events, diversion of resources, lack of essential drugs, and lack of personal protective equipment and sanitizer were identified as the main challenges faced during the pandemic.ConclusionThis study revealed that the utilization of maternal healthcare services in Ethiopia significantly decreased during the COVID-19 pandemic. Government measures, health facility-related barriers, and maternal-related factors were identified as challenges faced during the pandemic. Thus, service providers, policy-makers, and other relevant stakeholders should prioritize maternity care as an essential core healthcare service. Besides, increasing awareness of women through mass media, and making maternity services more accessible and equitable would likely increase the utilization of maternal healthcare services.Systematic review registrationPROSPEROCRD42021293681.
COVID-19 DI TWITTER : SOSIALISASI DAN EDUKASI DAN PERUBAHAN LANSKAP MEDIA
Authors: Widyawati Nina , M Santoso Widjajanti , Maulana Ikbal , Nadzir Daraini Ibnu , Windarsih Ana , Alamsyah Purnama 
Published: February 2023

Sosial media dianggap sebagai sumber penting dalam mencari informasi ketika pandemi Covid-19 terjadi, juga menunjukkan lanskap media sedang mengalami perubahan. Di satu sisi sosial media menghadirkan informasi sangat banyak, namun banyak diantaranya kurang akurat, sehingga memunculkan terminologi baru yang disebut infodemik. Di sisi lain, karena sifatnya interaktif, sosial media memiliki potensi sebagai alat sosialisasi dan edukasi program pemerintah. Jumlah akun sosial media di Indonesia cukup tinggi, sehingga dianggap juga sebagai penghasil infodemik. Hal ini dikhawatirkan mengganggu program pemerintah dalam mengatasi pandemi baik terkait masalah kesehatan maupun ekonomi. Oleh karena itu, tujuan penelitian ini adalah a) mendeskripsikan informasi yang sifatnya sosialisasi dan edukasi dan informasi yang sifatnya infodemik; b) melihat aktor yang memiliki pengaruh dalam menyampaikan pesan; c) memetakan perubahan lanskap media. Obyek studi adalah percakapan di Twitter selama 3 periode Pembatasan Sosial Berskala Besar (PSBB) yaitu PSBB Pertama, PSBB Transisi dan PSBB Ketat. Hasil penelitian menunjukkan bahwa masyarakat, pemerintah maupun organisasi masyarakat sipil melakukan sosialisasi dan edukasi Covid-19 melalui Twitter. Percakapan yang bersifat infodemik ditemukan tetapi tidak populer karena tidak banyak di re-Tweet. Dalam menyampaikan informasi, individu lebih berpengaruh daripada institusi media. Sedangkan lanskap media masih dalam tahap transisi. Agenda sosial media masih ditentukan oleh industri media karena jumlah cuitan industri media dominan.
Bird Sound Classification Using Deep Learning
Authors: JAIN UDBHAV 
Published: February 2023

With the high advancements in technology and cellular world, comes the frowning situation of endangering bird species. Bird sound classification and prediction model is a step towards the process of conserving the bird species.
The deep learning advancements helps to bring the solution to the problem of bird species identification from audio recordings. It is efficient and economical to identify and classify different bird species by audio recordings using machine learning algorithms and artificial models. Of course, there are challenges like choosing the right model that would minimize the signal to noise ratio between the training and test datasets.
Observing different experiments on a few models, CNN( Convolutional Neural Network ) and ANN( Artificial Neural Network ) promised highest accuracy of which ANN showed results. During the analysis of the dataset and model, the implementation graphical representation of the model performance and visual understanding of the dataset enhance the observation and provide more insightful knowledge of the dataset.
Bird identification is a difficult undertaking that frequently results in ambiguous labeling. Even skilled bird watchers dispute the species of a bird when presented with an image of one. It’s a demanding task that tests both people and computer’s visual talents. Although different bird species have the same core set of elements, their shape and appearance can change drastically. Due to differences in lighting and background, as well as great diversity in stance, intraclass variance is high (e.g., flying birds, swimming birds, and perched birds that are partially occluded by branches). Human knowledge of a species is insufficient to reliably identify a bird species, as it necessitates a great deal of skill in the subject of ornithology. Our study intends to use machine learning to assist amateur bird watchers in identifying bird species from photographs This research provides a deep neural network-based automate model for automatically identifying the species of a bird supplied as the test dataset. For 400 different bird species, the model was trained and evaluated.
Transformation eines Fähigkeitsmodells in einen PDDL-Planungsansatz
Authors: Vieira da Silva Luis Miguel , Heesch René , Köcher Aljosha , Fay Alexander 
Published: February 2023

Abstract
Automated planning approaches provide robust and efficient methods to automatically find plans for a given problem and a set of possible actions. However, due to the rather high effort required to create planning models, these approaches cannot be used for adaptable manufacturing plants. In this contribution, we present a method to automatically generate a planning problem in the form of PDDL from an existing capability model. This method eliminates the additional effort required to model a planning problem, making planning approaches usable for adaptable manufacturing plants.
Developing a skill-based flexible transport system using OPC UA
Authors: Jungbluth Simon , Barth Thomas , Nußbaum Jonathan , Hermann Jesko , Ruskowski Martin 
Published: February 2023

Abstract
Cyber-Physical Production Modules (CPPMs) must be described by vendor-independent and machine-readable standardized information models. Standards make CPPMs adaptable and interchangeable at different company levels to enable flexible production. We present an OPC UA information model for CPPMs based on the relevant OPC UA Companion Specifications. Combined with the skill concept, a transport system is controlled in an order-driven production. Additionally, we link different state machines to facilitate utilization functions for mission distribution between transport units.
A capability and skill model for heterogeneous autonomous robots
Authors: Vieira da Silva Luis Miguel , Köcher Aljosha , Fay Alexander 
Published: February 2023

Abstract
Teams of heterogeneous autonomous robots become increasingly important due to their facilitation of various complex tasks. For such heterogeneous robots, there is currently no consistent way of describing the functions that each robot provides. In the field of manufacturing, capability and skill modeling is considered a promising approach to semantically model functions provided by different machines. This contribution investigates how to apply and extend capability models from manufacturing to the field of autonomous robots and presents an approach for such a capability model.
The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
Authors: Abedi Behnaz , Tayefi-Nasrabadi Hossein , Kianifard Davoud , Basaki Mehdi , Shahbazfar Amir Ali , Piri Aiyoub , Dolatyarieslami Mahdi 
Published: February 2023

Abstract

Objectives
This in vivo study aimed to evaluate the effect of various concentrations of artemisinin (Art) alone or together with N-acetyl cysteine (NAC) on spermatological indices, antioxidant status, and histopathological parameters of testicular tissue in adult male mice.

Methods
Six groups of five healthy male mice (25–30 g) were randomly assigned to different experimental groups. These groups received DMSO and corn oil (0.1%) as an Art solvent (Control), 50 mg kg−1 Art (Art-50), 250 mg kg−1 Art (Art-250), 50 mg kg−1 Art + 150 mg kg−1 NAC (Art-50+NAC-150), 250 mg kg−1 Art + 150 mg kg−1 NAC (Art-250+NAC-150) and 150 mg kg−1 NAC (NAC-150) for a period of 7 days. Testes and epididymis were prepared to evaluate the malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), spermatological indices, and histological parameters.

Results
We showed that the high dose of Art (Art-250) significantly reduced the sperm count, motility, viability, and the activity of CAT and increased the levels of MDA compared to the control group. Also, the overdose of Art caused adverse changes in testicular tissue. Co-administration of NAC with Art (Art-250+NAC-150) corrected the adverse effects of Art.

Conclusions
The current study reports that a high dose of Art affects, spermatological parameters, antioxidant/stress oxidative status of the male reproductive system, and NAC is capable neutralize all adverse effects caused by Art.
SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
Authors: Huang Juan , Lv Chunhua , Zhao Baoyu , Ji Zhongqian , Gao Zhenran 
Published: February 2023

Abstract
Oral squamous cell carcinoma (OSCC) is a common tumor in the world. Despite the rapid development of medical care, OSCC is also accompanied by high incidence and mortality every year. Therefore, it is still necessary to continuously develop new methods or find new targets to treat OSCC. Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. This study aimed to explore the role and related molecular mechanisms of SCARA5 in OSCC. In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. In addition, SCARA5 repressed OSCC cell epithelial–mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. Finally, we found that SCARA5 could suppress STAT3, PI3K, and AKT phosphorylation. Therefore, SCARA5 was related to STAT3 and PI3K/AKT signaling pathways in OSCC. In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect.