bluuebunny/crossref_metadata_2025_split huggingface dataset:
The orbital period versus absolute magnitude relationship of intermediate polars: implications for low states and outbursts
Authors: Mukai Koji , Pretorius Magaretha L 
Published: May 2023

ABSTRACT
Recent advances in time-domain astronomy have led to fresh observational insights into intermediate polars, a subtype of magnetic cataclysmic variables generally accreting via a partial accretion disc. These new discoveries include detections of superhumps, low states, and outbursts. However, these studies have largely relied on relative photometry. Here, we tabulate the absolute G magnitudes of confirmed intermediate polars, plot them against their orbital periods, and compare the results to similar studies of dwarf novae during quiescence and in outburst. This exercise suggests the presence of two distinct luminosity classes of intermediate polars, with practical and physical implications for the studies of low states and outbursts. In particular, we point out that two of the optically luminous systems showing short outbursts are also seen to exhibit superhumps, suggesting that they may be caused by the same underlying mechanism.
Clinical implications of changes in metabolic syndrome status after kidney transplantation: a nationwide prospective cohort study
Authors: Lee Yu Ho , Song Sang Heon , Song Seung Hwan , Shin Ho Sik , Yang Jaeseok , Kim Myoung Soo , Hwang Hyeon Seok ,   the KOTRY Study Group, Ahn Curie , Yang Jaeseok , Kong Jin Min , Kwon Oh Jung , Kim Deok Gie , Jung Cheol-Woong , Kim Yeong Hoon , Kim Joong Kyung , Kim Chan-Duck , Min Ji Won , Park Sung Kwang , Park Yeon Ho , Berm Park Jae , Park Jung Hwan , Park Jong-Won , Ban Tae Hyun , Song Sang Heon , Song Seung Hwan , Shin Ho Sik , Yang Chul Woo , Yoon Hye Eun , Lee Kang Wook , Lee Dong Ryeol , Lee Dong Won , Lee Sam Yeol , Lee Sang-Ho , Lee Su Hyung , Lee Jung Jun , Lee Jung Pyo , Lee Jeong-Hoon , Jeon Jin Seok , Jun Heungman , Jeong Kyung Hwan , Chung Ku Yong , Cho Hong Rae , Ki Ju Man , Chae Dong-Wan , Choi Soo Jin Na , Han Duck Jong , Han Seungyeup , Ha Kyu 
Published: May 2023

ABSTRACT

Background
Metabolic syndrome (MetS) is prevalent in patients with end-stage kidney disease, and kidney transplantation is expected to modify the metabolic status. However, whether changes in metabolic status at the time of transplantation affect recipient outcomes remains unclear.

Methods
We analyzed 4187 recipients registered in a nationwide prospective cohort from 2014 to 2020. MetS was defined as the presence of three or more components of the metabolic syndrome. Patients were classified based on the pre- and post-transplant MetS status: MetS-free, MetS-developed, MetS-recovered and MetS-persistent. Study outcomes were occurrence of death-censored graft loss and a composite of cardiovascular events and death.

Results
Among recipients without pre-transplant MetS, 19.6% (419/2135) developed post-transplant MetS, and MetS disappeared in 38.7% (794/2052) of the recipients with pre-transplant MetS. Among the four groups, the MetS-developed group showed the worst graft survival rate, and the MetS-persistent group had a poorer composite event-free survival rate. Compared with the MetS-free group, the MetS-developed group was associated with an increased risk of graft loss [adjusted hazard ratio (aHR) 2.35; 95% confidence interval (CI) 1.17–4.98] and the risk of graft loss increased with increasing numbers of dysfunctional MetS components. MetS-persistent was associated with increased risks of cardiovascular events and death (aHR 2.46; 95% CI 1.12–5.63), but changes in the number of dysfunctional MetS components was not.

Conclusion
Kidney transplantation significantly alters the metabolic status. Newly developed MetS after transplantation was associated with an increased risk of graft loss, whereas persistent MetS exposure before and after transplantation was associated with increased risks cardiovascular events and patient survival.
Reducing meat and/or dairy consumption in adults: a systematic review and meta-analysis of effects on protein intake, anthropometric values, and body composition
Authors: Habumugisha Theogene , Engebretsen Ingunn Marie Stadskleiv , Måren Inger Elisabeth , Kaiser Carl Walter Matthias , Dierkes Jutta 
Published: May 2023

Abstract

Context
Consumers are increasingly encouraged to reduce meat and dairy consumption. However, few meta-analyses of randomized controlled trials (RCTs) on the effect of reducing meat and/or dairy on (absolute) protein intake, anthropometric values, and body composition are available.

Objective
The aim of this systematic review and meta-analysis was to evaluate the effect of reducing meat and/or dairy consumption on (absolute) protein intake, anthropometric values, and body composition in adults aged ≥ 45 years.

Data Sources
The MEDLINE, Cochrane CENTRAL, Embase, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases were searched up to November 24, 2021.

Data Extraction
Randomized controlled trials reporting protein intake, anthropometric values, and body composition were included.

Data Analysis
Data were pooled using random-effects models and expressed as the mean difference (MD) with 95%CI. Heterogeneity was assessed and quantified using Cochran’s Q and I2 statistics. In total, 19 RCTs with a median duration of 12 weeks (range, 4–24 weeks) and a total enrollment of 1475 participants were included. Participants who consumed meat- and/or dairy-reduced diets had a significantly lower protein intake than those who consumed control diets (9 RCTs; MD, −14 g/d; 95%CI, −20 to −8; I2 = 81%). Reducing meat and/or dairy consumption had no significant effect on body weight (14 RCTs; MD, −1.2 kg; 95%CI, −3 to 0.7; I2 = 12%), body mass index (13 RCTs; MD, −0.3 kg/m2; 95%CI, −1 to 0.4; I2 = 34%), waist circumference (9 RCTs; MD, −0.5 cm; 95%CI, −2.1 to 1.1; I2 = 26%), amount of body fat (8 RCTs; MD, −1.0 kg; 95%CI, −3.0 to 1.0; I2 = 48%), or lean body mass (9 RCTs; MD, −0.4 kg; 95%CI, −1.5 to 0.7; I2 = 0%).

Conclusion
Reduction of meat and/or dairy appears to reduce protein intake. There is no evidence of a significant impact on anthropometric values or body composition. More long-term intervention studies with defined amounts of meat and dairy are needed to investigate the long-term effects on nutrient intakes and health outcomes.

Systematic Review Registration
PROSPERO registration no. CRD42020207325.
Economic Consequences of Kinship: Evidence From U.S. Bans on Cousin Marriage
Authors: Ghosh Arkadev , Hwang Sam Il Myoung , Squires Munir 
Published: May 2023

Abstract
Close-kin marriage, by sustaining tightly knit family structures, may impede development. We find support for this hypothesis using U.S. state bans on cousin marriage. Our measure of cousin marriage comes from the excess frequency of same-surname marriages, a method borrowed from population genetics that we apply to millions of marriage records from the eighteenth to the twentieth century. Using census data, we first show that married cousins are more rural and have lower-paying occupations. We then turn to an event study analysis to understand how cousin marriage bans affected outcomes for treated birth cohorts. We find that these bans led individuals from families with high rates of cousin marriage to migrate off farms and into urban areas. They also gradually shift to higher-paying occupations. We observe increased dispersion, with individuals from these families living in a wider range of locations and adopting more diverse occupations. Our findings suggest that these changes were driven by the social and cultural effects of dispersed family ties rather than genetics. Notably, the bans also caused more people to live in institutional settings for the elderly, infirm, or destitute, suggesting weaker support from kin.
Labor Market Dynamics and Development
Authors: Donovan Kevin , Lu Will Jianyu , Schoellman Todd 
Published: May 2023

AbstractWe provide new evidence on how labor market dynamics vary with development. We build a new data set consisting of harmonized microdata from rotating panel labor force surveys covering 80 million people from 49 countries. Labor market flows, such as the job-finding or employment exit rate, are higher in developing economies. These higher flows largely reflect a slippery job ladder: workers transition frequently to and from marginal employment without climbing to or persisting in better-paying jobs. Subsistence self-employment and different patterns of selection for wage workers each play a role in our findings and are useful avenues for future theories of labor market frictions.
Search Frictions and Efficiency in Decentralized Transport Markets
Authors: Brancaccio Giulia , Kalouptsidi Myrto , Papageorgiou Theodore , Rosaia Nicola 
Published: May 2023

Abstract
We explore efficiency and optimal policy in decentralized transport markets, such as taxis, trucks, and bulk shipping. We show that in these markets, search frictions distort the transportation network and the dynamic allocation of carriers over space. We derive explicit and intuitive conditions for efficiency and show how they translate into efficient pricing rules, or optimal taxes and subsidies for the planner who cannot set prices directly. The results imply that destination-based pricing is essential to attain efficiency. Then, using data from dry bulk shipping, we demonstrate that search frictions lead to a sizable social loss and substantial misallocation of ships over space. Optimal policy can eliminate about half of the welfare loss. Can a centralizing platform, often arising as a market-based solution to search frictions, do better? Interestingly, the answer is no; although the platform eradicates frictions, it exerts market power, thus eroding the welfare gains. Finally, we use two recent interventions in the industry (China’s Belt and Road Initiative and the environmental initiative IMO 2020) to demonstrate that taking into account the efficiency properties of transport markets is germane to any proposed policy.
Exclusion of older adults from randomized controlled trials in rheumatoid arthritis
Authors: Mańko Anna , Raczkiewicz Anna , Górski Andrzej , Borysowski Jan , Wiland Piotr 
Published: May 2023

Abstract

Objectives
To assess eligibility criteria that either explicitly or implicitly exclude older patients from randomized controlled trials (RCTs) in RA.

Methods
Our analysis included RCTs of pharmacological interventions registered with ClinicalTrials.gov and started between 2013 and 2022. Co-primary outcomes were proportions of trials with an upper age limit and the eligibility criteria indirectly increasing risk of the exclusion of older adults.

Results
A total of 143/290 (49%) trials had an upper age limit of 85 years or less. Multivariable analysis showed that the odds of an upper age limit were significantly lower in trials performed in the USA [adjusted odds ratio (aOR), 0.34; CI, 0.12–0.99; P = 0.04] and intercontinental trials (aOR, 0.4; CI, 0.18–0.87; P = 0.02). In total, 154/290 (53%) trials had at least one eligibility criterion implicitly excluding older adults. These included specific comorbidities (n = 114; 39%), compliance concerns (n = 67; 23%), and broad and vague exclusion criteria (n = 57; 20%); however, we found no significant associations between these criteria and trial characteristics. Overall, 217 (75%) trials either explicitly or implicitly excluded older patients; we also noted a trend towards increasing proportion of these trials over time. Only one trial (0.3%) enrolled solely patients aged 65 and older.

Conclusion
Older adults are commonly excluded from RCTs in RA based on both age limits and other eligibility criteria. This seriously limits the evidence base for the treatment of older patients in clinical practice. Given the growing prevalence of RA in older adults, relevant RCTs should be more inclusive to them.
Close to me but unreachable: spotting the link between peripersonal space and empathy
Authors: Schiano Lomoriello Arianna , Cantoni Chiara , Ferrari Pier Francesco , Sessa Paola 
Published: May 2023

AbstractThe space surrounding the body [i.e. peripersonal space (PPS)] has a crucial impact on individuals’ interactions with the environment. Research showed that the interaction within the PPS increases individuals’ behavioral and neural responses. Furthermore, individuals’ empathy is affected by the distance between them and the observed stimuli. This study investigated empathic responses to painfully stimulated or gently touched faces presented within the PPS depending on the presence vs absence of a transparent barrier erected to prevent the interaction. To this aim, participants had to determine whether faces were painfully stimulated or gently touched, while their electroencephalographic signals were recorded. Brain activity [i.e. event-related potentials (ERPs) and source activations] was separately compared for the two types of stimuli (i.e. gently touched vs painfully stimulated faces) across two barrier conditions: (i) no-barrier between participants and the screen (i.e. no-barrier) and (ii) a plexiglass barrier erected between participants and the screen (i.e. barrier). While the barrier did not affect performance behaviorally, it reduced cortical activation at both the ERP and source activation levels in brain areas that regulate the interpersonal interaction (i.e. primary, somatosensory, premotor cortices and inferior frontal gyrus). These findings suggest that the barrier, precluding the possibility of interacting, reduced the observer’s empathy.
Promising or Predatory? Online Education in Non-Profit and For-Profit Universities
Authors: Smith Christian Michael , Villalobos Amber D , Hamilton Laura T , Eaton Charlie 
Published: May 2023

Abstract
Online education is a rapidly growing segment of the postsecondary system, and recent growth is concentrated at non-profit universities. Research shows that Black and low-income students are disproportionately represented in online programs; however, research on the outcomes of exclusively online education, especially at four-year non-profit universities, has been limited. Two narratives have emerged about the consequences of the access that online education provides: one describing it as promising and the other describing it as predatory. We harness both institution-level data and individual-level data to intervene in this debate. We show that online education is related to worse educational outcomes in non-profit and for-profit sectors, including lower retention and graduation rates. A sensitivity analysis suggests that selection into online education is unlikely to explain these results. Attending online is also related to some less desirable student loan repayment outcomes across sectors. Our results suggest that online education is a form of “predatory inclusion,” in that access is coupled with increased risks for students relative to comparable peers attending in-person. In light of our findings, we propose that the provision of online education by for-profit entities—even in the non-profit sector—may play a central role in producing poor student outcomes.
The prediction model of the aortic bifurcation
Authors: Khamanarong Kimaporn , Amnatbuddee Siriruthai , Sae-Jung Surachai , Mahiphot Jarupon , Chaisiwamongkol Kowit 
Published: May 2023

<p> </p>
<p><strong>Key Findings:</strong> The aortic bifurcation can be predetermined using the prediction model. The left common iliac artery (LCIA) was longer, more vertical, and closer to the lumbar spine than the right common iliac artery (RCIA). The formula of the diameter of the aorta, RCIA and LCIA is file:///C:/Users/ortho/AppData/Local/Temp/msohtmlclip1/01/clip_image002.png (D, diameter; a, aorta; r, RCIA; l, LCIA). The formula for the angle of aortic bifurcation is file:///C:/Users/ortho/AppData/Local/Temp/msohtmlclip1/01/clip_image004.png. Surgeons can use these formulas to predict and solve the problem when dealing with these arteries.</p>
Liquid-liquid extraction of lipidated peptides for direct identification of lipidation sites
Authors: Tsumagari Kazuya , Isobe Yosuke , Ishihama Yasushi , Seita Jun , Arita Makoto , Imami Koshi 
Published: May 2023

AbstractProteins can be modified by lipids in various ways, for example by myristoylation, palmitoylation, farnesylation, and geranylgeranylation—these processes are collectively referred to as lipidation. Current chemical proteomics using alkyne lipids has enabled the identification of lipidated protein candidates but does not identify endogenous lipidation sites and is not readily applicable toin vivosystems. Here, we introduce a proteomic methodology for global analyses of endogenous lipidation sites that combines liquid-liquid extraction of hydrophobic lipidated peptides with liquid chromatography-tandem mass spectrometry using a gradient program of acetonitrile in the high concentration range. We applied this method to explore lipidation sites in HeLa cells, and identified a total of 90 lipidation sites, including 75 protein N-terminal myristoylation sites, which is more than the number of high-confidence lipidated proteins identified by myristic acid analog-based chemical proteomics. Isolation of lipidated peptides from digests prepared with different proteases enabled the identification of different lipidated sites, extending the coverage. Moreover, our peptide-centric approach successfully identified dually modified peptides having myristoylation and palmitoylation. Finally, we analyzedin vivomyristoylation sites in mouse tissues and found that the lipidation profile is tissue-specific. This simple method (not requiring chemical labeling or affinity purification) should be a promising tool for global profiling of various protein lipidations.
Unveiling the three-step model for the interaction of imidazolium-based ionic liquids on albumin
Authors: Raw Juliana , Franco Leandro R. , Rodrigues Luiz Fernando de C. , Barbosa Leandro R. S. 
Published: May 2023

AbstractThe effect of the ionic liquids (ILs) 1-methyl-3-tetradecyl imidazolium chloride ([C14MIM][Cl]), 1-dodecyl-3-methylimidazolium chloride ([C12MIM][Cl]) and 1-decyl-methylimidazolium chloride ([C10MIM][Cl]) on the structure of bovine serum albumin (BSA) was investigated by fluorescence spectroscopic, UV-Vis spectroscopy, small an-gle X-ray scattering and molecular dynamics simulations. Concerning the fluorescence measurements, we observed a blue shift and a fluorescence quenching as IL concen-tration increased in the solution. Such behavior was observed for all three studied imidazolium-based IL, being larger as the number of methylene groups in the alkyl chain grew. UV-Vis absorbance measurements indicate that even at relatively small IL:protein ratios, like 1:1, or 1:2 ([C14MIM][Cl]) is able to change, at least partially, the sample turbidity. SAXS results agree with the spectroscopic techniques and sug-gest that the proteins underwent a partial unfolding, evidenced by an increase in the radius of gyration (Rg) of the scattering particle. In the absence and presence of ([C14MIM][Cl])=3mM BSARg, increases from 29.1 to 45.1 Å, respectively. Together, these results indicate that the interaction of BSA with IL is divided into three stages: the first stage is characterized by the protein in its native form. It takes place for IL:protein≤1:2 and the interaction is predominantly due to the electrostatic forces, provided by the negative charges on the surface of the BSA and the cationic polar head of the ILs. In the second stage, higher IL concentrations induce the unfolding of the protein, most likely inducing the unfolding of domains I and III, in such a way that the protein’s secondary structure is kept almost unaltered. In the last stage, IL micelles start to form and, therefore, interaction with protein reaches a saturation point and free micelles may be formed. We believe this work provides new information about the interaction of ILs with BSA.Graphical Abstract
Urinary protein changes during the short-term growth and development of rats
Authors: Liu Yuqing , Yang Minhui , Wang Haitong , Chen Yuzhen , Gao Youhe 
Published: May 2023

AbstractCan the urine proteome reflect short-term changes in the growth and development of animals? Do short-term developmental effects on urinary protein need to be considered when performing urine marker studies using model animals with faster growing periods? In this study, urine samples were collected from 10 Wistar rats aged 6-8 weeks 3 and 6 days apart. The results showed that the urine proteome could sensitively reflect short-term growth and development in rats. For example, comparing the urine proteome of Day 0 and Day 6, 195 differential proteins were identified after screening (FC ≥ 1.5 or ≤ 0.67, P < 0.05), and verified by randomization, the average number of randomly generated differential proteins was 17.99. At least 90.77% of the differential proteins were not randomly generated. This finding demonstrates that the differential proteins identified in the samples collected at different time points were not randomly generated. A large number of biological processes and pathways related to growth and development were enriched, which shows that the urine proteome reflects the short-term growth and development of rats, and provides a means for in-depth and meticulous study of growth and development. Moreover, an interfering factor in animal experiments using 6-to 8-week-old rats to construct models was identified. The results of this study demonstrated that there were differences in the urinary proteome in rats aged 6-8 weeks only 3-6 days apart, which suggests that the sensitivity of urinary proteomics is high and shows the sensitive and precise response of the urinary proteome to body changes.
Differential correction of gender imbalance for top-cited scientists across scientific subfields over time
Authors: Ioannidis John P.A. , Boyack Kevin W. , Collins Thomas A. , Baas Jeroen 
Published: May 2023

ABSTRACTWe evaluated how the gender composition of top-cited authors within different subfields of research has evolved over time. We considered 9,071,122 authors with at least 5 full papers in Scopus as of September 1, 2022. Using a previously validated composite citation indicator, we identified the 2% top-cited authors for each of 174 science subfields (Science-Metrix classification) in 4 separate publication age cohorts (first publication pre-1992, 1992-2001, 2002-2011, post-2011). Using NamSor we assigned 3,784,507 authors as men, and 2,011,616 as women (for 36.1% gender assignment uncertain). Men outnumbered women 1.88-fold among all authors, decreasing from 3.93-fold to 1.36-fold over time. Men outnumbered women 3.21-fold among top-cited authors, decreasing from 6.41-fold to 2.28-fold over time. In the youngest (post-2011) cohort, 32/174 (18%) subfields had >=50% women, 97/174 (56%) subfields had >=30% women, and 3 subfields had =<10% women among the top-cited authors. Gender imbalances in author numbers decreased sharply over time in both high-income countries (including the USA) and other countries, but the latter had little improvement in gender imbalances for top-cited authors. In random samples of 100 women and 100 men from the youngest (post-2011) cohort, in-depth assessment showed that most were currently (April 2023) working in academic environments. 32 women and 44 men had some faculty appointment, but only 2 women and 2 men were full professors. Our analysis shows large heterogeneity across scientific disciplines in the amelioration of gender imbalances with more prominent imbalances persisting among top-cited authors and slow promotion pathways even for the most-cited young scientists.