bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binder-free textile PAN-based electrodes for aqueous-based and glycerol-based supercapacitors
Authors: Barbosa Ingrid Ariani Belineli , Marcuzzo Jossano Saldanha , de Faria Rubens Nunes , Consentino Ivana Conte 
Published: March 2023

Abstract
Amidst different types of energy storage systems, electric double-layer capacitors (EDLCs), also known as supercapacitors, have received considerable attention as energy storage alternatives due to their advantageous characteristics: high power density, long-life cycle, lightweight, safe operations, and fast charge-discharge rates. This work addresses these EDLC devices and has been divided into two parts. In the former, the synthesis and characterization of activated carbon fiber-felt (ACFF) electrodes from textile PAN fiber have been provided. In the latter, electrochemical characterization of the ACFF electrodes in potassium hydroxide solutions (aqueous-based) and in potassium hydroxide-glycerol hybrid electrolytes (glycerol-based electrolytes) have been investigated. The synthesis of ACFF electrodes via two-step oxidation, carbonization, and physical activation resulted in low-cost and binder-free electrodes containing mostly micropores (maximum pore width of 3 nm) and a specific surface area of 1875 m2 g− 1. Electrochemical impedance spectroscopy, cyclic voltammetry, and galvanostatic charge-discharge techniques were carried out in a symmetric two-electrode setup at room temperature. The results showed that ACFF-based EDLCs in aqueous-based electrolyte (2 M KOH) exhibited low electrolyte resistance (0.44 ± 0.04 Ω cm2) and high gravimetric capacitance (129 ± 6 F g− 1 at 1 mV s − 1). Although ACFF-based EDLCs in glycerol-based electrolytes exhibited high electrolyte resistance (> 17 ± 2 Ω cm2), they are hybrid green-electrolytes that support a large potential window (< 2.5), which is greater than that of aqueous electrolytes (≈ 1 V). Crude glycerol, the main byproduct in biodiesel production, is non-toxic, relatively safe, and low-cost. The advantages and disadvantages of aqueous and glycerol-based electrolytes have been discussed.
Clinical significance of peripheral TCR repertoire profiling and individualized nomograms in patients with gastrointestinal cancer treated with anti-PD-1 antibody
Authors: Wu Jing , Yu Yiyi , Zhang Shilong , Zhang Pengfei , Yu Shan , Li Wei , Wang Yan , Li Qian , Lu Binbin , Chen Limeng , Luo Chonglin , Peng Haixiang , Liu Tianshu , Cui Yuehong 
Published: March 2023

Abstract
Background
Immune checkpoint inhibitors (ICIs) have significant clinical benefit for a subset of patients with gastrointestinal cancers including esophageal cancer, gastric cancer and colorectal cancer. However, it is difficult to predict which patients will respond to immune therapy or induce immune-related adverse events (irAEs). This study was initiated to determine if peripheral T-cell receptor (TCR) repertoire profiling could predict the clinical efficacy of anti-PD-1 treatment, while also predict adverse events.
Methods
Blood samples from 31 patients with GICs were collected before anti-PD-1 antibody treatment initiation. The clinical significance of TCR repertoire profiling from PBMCs was evaluated in all the enrolled patients. A highly predictive nomogram was set up based on peripheral TCR repertoire profiling. The performance of the nomogram was assessed by receiver operating characteristic (ROC) curve, concordance index (C-index), and calibration curves, and decision curve analysis (DCA) was used to assess its clinical applicability.
Results
Compared to non-responders (PD), the DE50 scores were significantly higher in responders (SD and PR) (P = 0.018). There was a trend that higher DE50 at baseline was associated with the occurrence of adverse events, but it did not reach statistical significance (P = 0.1779). Patients with a high DE50 score showed better progression-free survival (PFS) than those with a low DE50 score (P = 0.0022). The multivariable Cox regression demonstrated that high DE50 and low PLR were significant independent predictors for better PFS when treated with anti-PD-1 antibody. Furthermore, a highly predictive nomogram was set up based on peripheral TCR repertoire profiling. The AUCs of this system at 3-, 6- and 12-month PFS reached 0.825, 0.802, and 0.954, respectively. The nomogram had a C-index of 0.768 (95% CI: 0.879 − 0.658). Meanwhile, the calibration curves also demonstrated the reliability and stability of the model.
Conclusions
High DE50 scores were predictive of a favorable response and longer PFS to anti-PD-1 treatment in GIC patients. The nomogram based on TCR repertoire profiling was a reliable and practical tool, which could provide risk assessment and clinical decision-making for individualized treatment of patients.
Palatal approach for surgical removal of mesioangularly impacted maxillary third molar - a cohort study
Authors: Sun Rui , Sun Yu-Qi , Cai Yu , Zhao Ji-Hong 
Published: March 2023

Abstract
Objective

This study aimed to investigate the application of palatal approach to perform IMTM extraction, and evaluate its operation successful rate, surgical time, postoperative outcomes, and complications incidence.

Method

Patients, with Class B mesioangularly IMTM in the none-buccal position of the adjacent second molar, were enrolled in this study if the teeth were indicated for extraction. The patients were randomly assigned into two groups according to the surgical approach: buccal approach or palatal approach. The impacted tooth positions, diagnosis, past dental and medical history, and radiographic examination were recorded pre-operatively. During the surgery, the duration time, the surgery detail, and surgical complications were documented.

Result

40 teeth were enrolled in our study. All teeth were extracted. The operation time was significantly shorter in the palatal approach group compared to the buccal approach group (13.3 ± 2.8 min vs. 22.3 ± 5.5 min, P༜0.001). The rate of traumatic ulcers of the lips was significantly higher in the buccal approach group than in the palatal approach group (7/20 vs. 0/20, P = 0.008).

Conclusion

It is more efficient to perform surgery with a palatal approach if a Class B mesioangularly IMTM is located in the non-buccal aspect of the adjacent second molar.
Clinical trial registration number: ChiCTR2000040063
Accelerated degradation of four OP insecticides by malathion tolerant Aspergillus niger M- RU01
Authors: Mohapatra Debasish , Rath Sakti Kanta , Mohapatra Pradipta Kumar 
Published: March 2023

Abstract
Insecticides are widely used in agriculture, horticulture, medicine, and industry, as well as domestically. Increased insecticide application has been attributed to higher agricultural productivity and lower infield and postharvest crop loss in the twentieth century. Malathion is a very commonly used organophosphorus (OP) insecticide applied in over 100 food crops in agriculture and post-harvest storage. Different species of Aspergillus have shown their efficiency to degrade OP chemicals. A malathion tolerant Aspergillus niger MRU01, developed by prolonged malathion exposure, was tested for its efficiency to remove malathion as well as three other commonly used OP insecticides, viz., parathion, chlorpyrifos and dimethoate. The tolerant strain showed growth efficiency as well enhanced production of phosphatases and esterase enzyme as compared to untreated as well as treated wild type (A. niger MTCC16404). The removal of malathion was 29% and 68%, in the wild type and the tolerant strain, respectively during five days. The tolerant strain was also able to remove dimethoate (63%) and chlorpyrifos (54%) with high efficiency while a low rate of removal of parathion (33%) was observed. The strain can be applied in field for bioremediation.
Scandinavian trial of Uncomplicated Aortic Dissection Therapy: study protocol for a randomized controlled trial
Authors: Rudolf Claudina , Lindberg Beate Rikken , Resch Timothy , Mani Kevin , Björkman Patrick , Laxdal Elín Hanna , Støvring Henrik , Beck Henriette Margrethe , Eriksson Gunnar , Budtz-Lilly Jacob 
Published: March 2023

Abstract
Background: Contemporary management of uncomplicated type B aortic dissections (uTBAD) is based on the acuity and various morphological features. Medical therapy is mandatory, while the risks of early thoracic endovascular aortic repair (TEVAR) are balanced against the potential for rupture, complex surgery, and death. Improved aortic morphology following TEVAR is documented, but evidence for improved overall survival is lacking. The costs and impact on quality-of-life are also needed.
Methods: The trial is a randomized, open label, superiority clinical trial with parallel assignment of subjects at 23 clinical sites in Denmark, Norway, Sweden, Finland, and Iceland. Eligibility includes patients aged ≥ 18 with uTBAD of < 4 weeks duration. Recruited subjects will be randomized to either standard medical therapy (SMT) or SMT+TEVAR, where TEVAR must be performed between 2-12 weeks from the onset of symtpoms.
Discussion: This trial will evaluate the primary question of whether early TEVAR improves survival at 5 years among uTBAD patients. Moreover, the costs and the impact on quality-of-life should provide sorely needed data on other factors that play a role in treatment strategy decisions. The common Nordic healthcare model, with inclusion of all aortic centers, provides a favorable setting for carrying out this trial, while the robust healthcare registries ensure data validity.
Trial registration: clinicaltrials.gov: NCT05215587, posted January 31, 2022
The High Cost of Healing and Teaching: A Cross-sectional Survey of Burnout Among Academic Physicians in Nigeria
Authors: Oluwadiya Kehinde Sunday , Olutayo Adeoti Adekunle , Adeoye Oyewole , Omowumi Oluwadiya Ibironke , Olasinde Anthony A , Kadiri Innih A 
Published: March 2023

Abstract
Background: Globally, the medical and teaching professions are two major professions with the highest prevalence of burnout, and academic physicians bestride the two professions. This study investigated the prevalence and associated factors of burnout among academic physicians working in tertiary hospitals in Nigeria.
Methodology: This was a self-administered online survey. Burnout was measured using the Maslach Burnout Inventory and sent to 256 academic physicians in tertiary hospitals across Nigeria using the WhatsApp broadcast feature.
Findings: A total of 150 Academic Physicians responded, of which there were 121 (80.7%) males and 29 (19.3%) females. The prevalence of burnout in our study was 57.7%. Moderate emotional exhaustion was reported by 12.3% (18 respondents), high emotional exhaustion by 18.5% (27 respondents), moderate depersonalization by 4.8% (7 respondents), high depersonalization by 0.7% (1 respondent), moderate personal accomplishment by 10.4% (16 respondents), and high personal accomplishment by 33.1% (51 respondents). Eight variables: religion, geopolitical zone of practice, enjoyment of academic writing, apathy toward teaching, university ownership, number of published peer-reviewed articles, salary, and supplementary income were significantly associated with emotional exhaustion, while the number of weeks spent teaching in a year and teaching hours/week were significantly associated with depersonalization and personal accomplishment, respectively. Age (OR 1.302, CI 1.080-1.570), Teaching hours/week (OR 0.924, CI 0.854-0.999), Salary (OR 0.996, CI 0.993-1.0), and supplementary salary (OR 0.996, CI 0.993-0.999) were found to significantly predict emotional exhaustion.
Conclusion: The high prevalence of burnout among academic physicians in Nigeria highlights the need for further research and implementation of preventive measures
Spatio-Temporal Analysis on Channel Migration of the Jiadhal River Basin Using Geospatial Techniques
Authors: Mili Monalisha , Bhuyan Manash Jyoti , Mishra Dinky 
Published: March 2023

Abstract
Jiadhal is one of the most notorious rivers of Assam, flowing through the northern bank of the river Brahmaputra. The river is mostly known for its frequent bank line shifting andcreating floods, particularly in the Dhemaji district of Assam. Channel migration in the Jiadhal River is a common phenomenon. A spatio-temporal change inthe river has been revealed by the analysis of Landsat TM imagery over 26 years in the GIS environment. In order to examine the temporal channel migration, 59.30 km of the river's total length was divided into 11 parts by taking cross-sections at equal intervals of 6 km. Uneven rainfall patterns, embankment construction, sand mining, and the development of dams, barrages, and roadways all have an impact on the river's hydrological system.It is noteworthy that human activities aggravating the morpho-ecological changes of the river are the main reasons for river channel migration, independent of natural hydrological processes.The riverbed's unevenness and undulation have significantly increased as a result of this. Therefore, the present paper analyses the spatio-temporal variations of channel migration in the lower Jiadhalbasin using geospatial techniques.
Model Transformation based Closed-Form IA Design for Multiple-Cell MIMO Cellular Networks
Authors: Liu Weihua , Song Wenjun , Yu Zeqi , Dun Hui , Xue Huiying 
Published: March 2023

Abstract

To apply the interference alignment (IA) technology to practical communication networks effectively, the low complexity IA design problem still needs to be solved well. In this paper, we study the low complexity closed-form IA design method, for the multiple-cell multiple-user multiple-input multiple-output (MIMO) cellular interference network. To eliminate the complex interference conveniently, the multiple-cell multiple-user cellular network model is transformed into several relatively simple network models. Based on the model transformation of the cellular network, the IA precoding is divided into two parts. Then the two-stage IA design scheme is proposed, which includes the outer IA design and inter one. The former is to eliminate the inter-cell interference, while the latter is to eliminate the inter-user interference. Simulation results show the higher system sum-rate performance and low computational complexity of the proposed IA design scheme.
Machine learning based novel frameworks developments and architectures for secured communication in VANETs for smart transportation
Authors: Chakraborty Rakhi , Kumar Sunil , Awasthi Aishwary , K Suneetha , RASTOGI AJAY , Jethava Gordhan 
Published: March 2023

Abstract
Vehicle ad hoc networks have made intelligent transportation systems that significantly increase road safety as well as management possible. Vehicles can now communicate and share information about the road using this new technology. However, malicious users might inject fake emergency alerts into VANET, making it impossible for nodes to access accurate road information. In vehicular ad hoc networks, assessing credibility of nodes has become a crucial task to ensure reliability as well as trustworthiness of data. Using machine learning methods, this study proposes a novel security technique that improves communication and intruder detection in VANET for smart transportation. Ciphertext-policy game theory encryption analysis for smart transportation is used here to improve the security of the VANET. Fuzzy rule-based encoder perceptron neural networks are utilized in the detection of the VANET intruder. For a variety of network datasets, the experimental analysis is conducted in terms of throughput, QoS, latency, computational cost, and data transmission rate.
Facies analysis and depositional evolution of Lower-Middle Ordovician carbonates in the Shuntuoguole Low Uplift of Tarim Basin (NW China)
Authors: Han Jun , Chen Daizhao , Xiao Chongyang , Huang Cheng , Wang Shi , Chen Jingping , Guo Chuan 
Published: March 2023

Abstract
The depositional evolution of the Early to Middle Ordovician carbonate platform in the Shuntuoguole Low Uplift (Tarim Basin, NW China) is controversial, leading to difficulty in understanding the distributional pattern of depositional facies and its controls and in petroleum exploration. Integrated with geophysical analyses, detailed sedimentological observations were carried out on the Lower-Middle Ordovician carbonate successions of the Shuntuoguole Low Uplift, in order to recognize the depositional facies and sequences and to reveal the carbonate platform evolution. The results show that a carbonate ramp system developed in the Shuntuoguole Low Uplift during the Early-Middle Ordovician. In such a depositional system, twelve types of lithofacies were recognized, which are arranged into two facies belts (or associations), including peritidal to semi-restricted subtidal and open-marine subtidal facies. Based on the spatiotemporal distribution of lithofacies (or facies), seven third-order depositional sequences were recognized in the Lower-Middle Ordovician carbonate successions. Individual sequences are composed of a transgressive package in the lower part and a regressive one in the upper part. And the sequence boundaries are commonly characterized by transitional zones without remarkable subaerial exposure features. And the Lower-Middle Ordovician carbonate successions were subdivided into three depositional phases during the long-term evolution of the carbonate platform, which were primarily characterized by semi-restricted to open-marine subtidal facies, peritidal through semi-restricted to open-marine subtidal facies, and open-marine subtidal facies, respectively. The correlation of relative sea-level (or accommodation spaces) changes derived from the vertical stacking pattern of facies with the global sea-level curve of Haq and Schutter (2008) and sea-level oscillations of coeval successions worldwide suggests that the eustatic sea-level fluctuation was an overriding factor controlling the development and evolution of carbonate ramp in the study area during the Early-Middle Ordovician. Meanwhile, regional or local tectonic subsidence and other environmental factors (e.g., paleotopography) also exerted an influence on the deposition processes at this time interval.
Treating Nightmares in Posttraumatic Stress Disorder with Dronabinol: Study Protocol of a Multicenter Randomized Controlled Study (THC PTSD-trial)
Authors: Roepke Stefan , Schoofs Nikola , Priebe Kathlen , Wülfing Felix , Schmahl Christian , Röhle Robert , Zähringer Jenny , Lotter Tobias , Otte Christian , Koglin Stefanie 
Published: March 2023

Abstract
Background
Distressing nightmares are a core symptom of posttraumatic stress disorder (PTSD) and contribute to psychiatric comorbidity, impaired physical health and decreased social functioning. No specific pharmacological treatment for PTSD-related nightmares is yet approved. Preliminary clinical data indicate that cannabinoid agonists can improve nightmares and overall PTSD symptoms in patients with PTSD. The primary objective of the study is to examine the efficacy of oral dronabinol (BX-1) versus placebo in reducing nightmares in patients with PTSD. The secondary objectives of the study are to examine the efficacy of oral BX-1 in reducing other PTSD symptoms.
Methods
The study is designed as a multi-centric, double-blind, randomized (1:1), placebo-controlled, parallel group interventional trial. Eligible patients will be randomized to BX-1 or placebo, receiving a once-daily oral dose before bedtime for 10 weeks. Primary efficacy endpoint is the Clinician-Administered PTSD Scale (CAPS-IV) B2 score for the last week, measuring frequency and intensity of nightmares. Secondary efficacy endpoints are other disorder-specific symptoms in patients with PTSD. Further, tolerability and safety of dronabinol will be assessed.
Discussion
This randomized controlled trial will provide evidence whether treating patients with PTSD and nightmares with dronabinol is safe and efficacious.
Trial registration
NCT04448808, EudraCT 2019-002211-25
Exosomal circTGFBR2 promotes hepatocellular carcinoma progression via enhancing ATG5 mediated protective autophagy.
Authors: Wang Xin , Dong Fenglin , Wang Yingqiao , Wei Honglong , Li Tao , Li Jie 
Published: March 2023

Abstract
Exosomes contribute substantially to the communication between tumor cells and normal cells. Benefiting from the stable structure, circular RNAs (circRNAs) are believed to serve an important function in exosome-mediated intercellular communication. Here, we focused on circRNAs enriched in starvation-stressed hepatocytic exosomes and further investigated their function and mechanism in hepatocellular carcinoma (HCC) progression. Differentially expressed circRNAs in exosomes were identified by RNA sequencing, and circTGFBR2 was identified and chosen for further study. The molecular mechanism of circTGFBR2 in HCC was demonstrated by RNA pulldown, RIP, dual-luciferase reporter assays, rescue experiments and tumor xenograft assay both in vitro and vivo. We confirmed exosomes with enriched circTGFBR2 led to an upregulated resistance of HCC cells to starvation stress. Mechanistically, circTGFBR2 delivered into HCC cells via exosomes serves as a competing endogenous RNA by binding miR-205-5p to facilitate ATG5 expression and enhance autophagy in HCC cells, resulting in resistance to starvation. Thus, we revealed that circTGFBR2 is a novel tumor promoter circRNA in hepatocytic exosomes and promotes HCC progression by enhancing ATG5–mediated protective autophagy via the circTGFBR2/miR-205-5p/ATG5 axis, which may be a potential therapeutic target for HCC.
Comparison of pericapsular nerve group (PENG) block with fascia iliaca compartment block (FICB) in hip fractures: a systematic review and meta-analysis of randomized controlled trials
Authors: Miao Yuxin , Wang Xiaoyu , Li Zongxiao , Zhang Xiaoxu , Niu Zejun 
Published: March 2023

Abstract

Background The purpose of the study is to evaluate and compare the effectiveness of two different anesthesia techniques, PENG block and fascia iliaca compartment block (FICB), in managing pain and minimizing side effects for patients undergoing hip fracture surgery. Due to increasing numbers of patients with comorbidities, anesthesia for hip fractures has become a significant challenge. Methods From the initiation of the study until April 26, 2022, a comprehensive search was conducted across several electronic databases, including PubMed, Embase, Cochrane Library, CNKI, and WanFang Data, to identify relevant studies. The focus of the search was randomized controlled trials (RCTs) that compared the clinical efficacy of PENG block and FICB in hip fracture surgery. To ensure the validity of the study, two independent reviewers applied the standards of the Cochrane systematic review to evaluate and index all the papers. In case of heterogeneity between studies, a random-effects model was utilized, and a fixed-effects model was employed otherwise. Results According to the combined data, PENG block can decrease 24-hour postoperative opioid consumption (P༜0.05), but its 48-hour postoperative opioid consumption is not significantly different from control group (CI [-12.27, 2.79], P = 0.22). There are also no differences in side effects (CI [0.13,4.57], P = 0.76) and dynamic or static pain scores (P༞0.05) . Conclusions The results of the meta-analysis indicate that PENG blocks are effective in reducing opioid consumption for 24 hours post-hip fracture surgery. This implies that PENG blocks may be a promising alternative for reducing pain and minimizing the risk of substance abuse in patients. However, to establish this with certainty, more research with larger sample sizes and longer-term follow-up in the form of prospective randomized controlled trials is necessary.