bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of nitric oxide synthase gene polymorphism with asthma: A systematic review and meta‐analysis
Authors: Fan Zeru , Liu Tao , Na Wei 
Published: April 2023

AbstractIntroductionThis study examines the associations between asthma and nitric oxide (NO) synthase (NOS) gene polymorphisms.MethodsAfter a systematic literature search in electronic databases, studies were selected based on eligibility criteria. Data were extracted from research articles and were synthesized and tabulated. Where a particular polymorphism data were reported by multiple studies, meta‐analyses of odds ratios were performed, or odds ratios reported by individual studies were pooled.ResultsTwenty studies (4450 asthma patients and 5306 non‐asthmatic individuals) were identified. Many studies did not find any association between CCTTT repeat polymorphism in NOS2 gene and asthma. However, a study reported that pretreatment mean exhaled NO levels in asthmatics were found to be significantly higher in genotypes with higher number of CCTTT repeats. Also, alleles with <11 CCTTT repeats were associated with poor asthma treatment outcomes. A single nucleotide polymorphism, G894T, in NOS3 gene was not found to be significantly associated with asthma by at least four studies. However, a T allele at this locus was associated with lower NO levels. Also, G894T frequency was significantly higher in asthmatic children who responded to inhaled corticosteroids along with long‐lasting beta2‐agonists. A T allele of NOS3 786C/T polymorphism increased the probability of bronchial asthma with comorbid essential hypertension in asthma patients. Asthma severity also differed for different Ser608Leu exon 16 variants of NOS2 gene.ConclusionsSeveral polymorph NOS gene variants are identified, some of which appear to have influence on asthma prevalence or outcomes. However, data are varying depending on the nature of variant, ethnicity, study design, and disease parameters.
Do psychotic experiences act as effect modifiers in youths with common mental health problems allocated to transdiagnostic cognitive behavioural therapy versus management as usual? Secondary analyses of the Mind‐My‐Mind randomized trial
Authors: Rimvall Martin Køster , Vassard Ditte , Christensen Robin , Nielsen Sabrina Mai , Pagsberg Anne Katrine , Correll Christoph U. , Jeppesen Pia 
Published: April 2023

AbstractBackgroundPsychotic experiences (PEs) are common in help‐seeking youths with non‐psychotic mental health problems, yet the clinical importance of PEs as potential effect modifiers of psychotherapy interventions has been scarcely examined. We examined if PEs were associated with a differential response to transdiagnostic cognitive behavioural therapy (CBT) aimed at common emotional and behavioural problems.MethodsWe present secondary analyses from the Mind My Mind (MMM) trial that randomized 396, 6‐16‐year‐old youths to either 9–13 sessions of transdiagnostic modular community‐based CBT (MMM) or community‐based management as usual (MAU). MMM was superior to MAU in reducing parent‐reported impact of mental health problems according to the Strengths and Difficulties Questionnaire (SDQ). PEs were assessed by semi‐structured screening interviews at baseline. The contrast between subgroups (presence/absence of PEs) was calculated to test if PEs are potential effect modifiers regarding the change in parent‐reported SDQ‐impact (primary outcome, rated 0[low]‐10[high]) and other SDQ‐related outcomes.ResultsBaseline PEs were present in 74 (19%) of youths. The superior effect of MMM on changes in SDQ‐impact from baseline to week 18 was not effect modified by the presence of PEs (PEs[yes] −0.89 [95%CI −1.77;‐0.01] vs. PEs[no] −1.10 [95%CI −1.52;‐0.68], p‐value for interaction .68). For secondary outcomes similar patterns were observed.Limitations Statistical power was limited to show if PEs modified treatment response. Replication and meta‐analytic evidence are needed.ConclusionsThe beneficial effects of MMM transdiagnostic CBT did not differ by PE‐status, indicating that youths with emotional and behavioural problems could be offered such psychotherapy irrespective of co‐occurring PEs.
Large fibrosarcoma of the equine distal limb treated by surgical excision using a harmonic scalpel
Authors: Bellitto Nicholas A. , McMaster Mattie , Alvim Ailidh , Byrne Christian A. 
Published: April 2023

SummaryAn 18‐year‐old Warmblood gelding was presented for investigation of a large, firm mass over the medial and plantar aspect of the left distal metatarsal and fetlock region. The mass was first identified 4 months prior to referral, following a traumatic incident, and had over time gradually increased in size. Clinical examination and diagnostic imaging revealed a large soft tissue mass adjacent to the metatarsophalangeal joint and digital flexor tendon sheath, with no overt involvement of underlying bone. The mass was surgically excised under general anaesthesia using a harmonic scalpel with limited margins to avoid compromise of adjacent anatomical structures. Following histology, the mass was diagnosed as a fibrosarcoma. Twelve months after surgical resection, no signs of recurrence were evident. This report demonstrates that fibrosarcoma of the equine distal limb may be successfully managed with surgical excision. The use of a harmonic scalpel should be considered as an alternative to sharp excision when treating fibrosarcoma or other infiltrative tumours, particularly those located in regions where only limited surgical margins may be achieved.
Longitudinal effects of pandemic stressors and dyadic coping on relationship satisfaction during the COVID‐19 pandemic
Authors: Carrese‐Chacra Emily , Hollett Kayla , Erdem Gizem , Miller Sydney , Gouin Jean‐Philippe 
Published: April 2023

AbstractObjectiveThis study examined changes in relationship satisfaction during the COVID‐19 pandemic and the moderating roles of financial strain, perceived threat of COVID‐19, and dyadic coping.BackgroundThe systemic‐transactional model of dyadic coping posits that relationship satisfaction varies as a function of the stressors partners face and their engagement in dyadic coping.MethodAbout 188 partnered adults completed questionnaires at three time points during the initial confinement period of the COVID‐19 pandemic and at a 20‐month follow‐up.ResultsRelationship satisfaction increased during the first confinement period and returned to its baseline level at the 20‐month follow‐up. Greater financial strain and perceived threat of COVID‐19 were associated with poorer relationship satisfaction over time. Dyadic coping buffered the negative impact of financial strain on relationship satisfaction during the initial confinement period, but not 20 months later.ConclusionsMost individuals were resilient to the effect of pandemic stressors on relationship satisfaction. The buffering effect of dyadic coping was observed during the initial confinement period when access to support resources outside the family unit was curtailed.ImplicationsIntervention efforts to promote dyadic coping and financial well‐being for couples may be especially helpful in the context of strict confinement measures.
Does treatment of brown trout with the parasite causing PKD increase stocking success and boost resilience against the disease?
Authors: Ros Albert , Baer Jan , Brinker Alexander 
Published: April 2023

AbstractIn Salmonidae, infections with the parasite Tetracapsuloides bryosalmonae may lead to a temperature‐dependent proliferative disease of the kidney (PKD). Trout that survive infection and recover become resistant to the disease. The use of this approach to improve brown trout (Salmo trutta) stocking success was tested in three PKD‐affected streams in southern Germany. Fish were treated using local spores of the parasite and kept at low temperatures (14°C) to not develop the disease. Controls were similarly kept but not treated with spores. Independent of time of stocking (winter or spring), recapture rates for both control and parasite‐treated stocked trout were very low (<1%). However, recaptured parasite‐treated trout exhibited lower parasite prevalence than control and wild‐caught trout.
Adding to the mix – Challenges of mixed‐fisheries management in the North Sea under climate change and technical interactions
Authors: Kühn Bernhard , Kempf Alexander , Brunel Thomas , Cole Harriet , Mathis Moritz , Sys Klaas , Trijoulet Vanessa , Vermard Youen , Taylor Marc 
Published: April 2023

AbstractTechnical interactions (multiple fleets fishing multiple species with various gears, as either target or bycatch), bycatch regulations through a landing obligation, and biological and economic effects of climate change, affecting fisheries yield and profits, provide a challenge for demersal mixed fisheries of the North Sea. A multi‐stock, multi‐fleet, bioeconomic model was used to understand management options under these combined influences. Scenarios considered climate change effects on recruitment of three main gadoid stocks (cod – Gadus morhua, saithe – Pollachius virens, whiting – Merlangius merlangus), possible future developments of fuel and fish prices, and strict implementation of a landing obligation. The latter leads to decreased yield and profits in the short term due to increased choke effects, mainly of North Sea cod, being influenced by climate‐induced productivity changes. Allowing fishing above FMSY, but within sustainable limits, or limiting year‐to‐year quota changes, could help buffer initial losses at the expense of decreased profits in the mid‐ to long‐term. Economic performance of individual fleets was linked to their main target's stock status, cost structure, and fuel and fish prices. The results highlight a need to consider both biological and economic consequences of climate change in the management of mixed fisheries.
A global synthesis of climate vulnerability assessments on marine fisheries: Methods, scales, and knowledge co‐production
Authors: Li Yunzhou , Sun Ming , Kleisner Kristin M. , Mills Katherine E. , Chen Yong 
Published: April 2023

AbstractUndertaking climate vulnerability assessments (CVAs) on marine fisheries is instrumental to the identification of regions, species, and stakeholders at risk of impacts from climate change, and the development of effective and targeted responses for fisheries adaptation. In this global literature review, we addressed three important questions to characterize fisheries CVAs: (i) what are the available approaches to develop CVAs in various social–ecological contexts, (ii) are different geographic scales and regions adequately represented, and (iii) how do diverse knowledge systems contribute to current understanding of vulnerability? As part of these general research efforts, we identified and characterized an inventory of frameworks and indicators that encompass a wide range of foci on ecological and socioeconomic dimensions of climate vulnerability on fisheries. Our analysis highlighted a large gap between countries with top research inputs and the most urgent adaptation needs. More research and resources are needed in low‐income tropical countries to ensure existing inequities are not exacerbated. We also identified an uneven research focus across spatial scales and cautioned a possible scale mismatch between assessment and management needs. Drawing on this information, we catalog (1) a suite of research directions that could improve the utility and applicability of CVAs, particularly the examination of barriers and enabling conditions that influence the uptake of CVA results into management responses at multiple levels, (2) the lessons that have been learned from applications in data‐limited regions, particularly the use of proxy indicators and knowledge co‐production to overcome the problem of data deficiency, and (3) opportunities for wider applications, for example diversifying the use of vulnerability indicators in broader monitoring and management schemes. This information is used to provide a set of recommendations that could advance meaningful CVA practices for fisheries management and promote effective translation of climate vulnerability into adaptation actions.
Barriers and facilitators to HIV Pre‐Exposure Prophylaxis (PrEP) in Specialist Sexual Health Services in the United Kingdom: A systematic review using the PrEP Care Continuum
Authors: Coukan Flavien , Murray Keitumetse‐Kabelo , Papageorgiou Vasiliki , Lound Adam , Saunders John , Atchison Christina , Ward Helen 
Published: April 2023

AbstractObjectivesHIV pre‐exposure prophylaxis (PrEP) delivery in the UK is inequitable; over 95% of PrEP users were men who have sex with men (MSM) despite making up less than 50% of new HIV diagnoses. We conducted a systematic review to identify modifiable barriers and facilitators to PrEP delivery in the UK among underserved populations.MethodsWe searched bibliographic/conference databases using the terms HIV, PrEP, barriers, facilitators, underserved populations, and UK. Modifiable factors were mapped along the PrEP Care Continuum (PCC) to identify targets for interventions.ResultsIn total, 44 studies were eligible: 29 quantitative, 12 qualitative and three mixed‐methods studies. Over half (n = 24 [54.5%]) exclusively recruited MSM, whereas 11 were in mixed populations (all included MSM as a sub‐population) and the other nine were in other underserved populations (gender and ethnicity minorities, women, and people who inject drugs). Of the 15 modifiable factors identified, two‐thirds were at the PrEP contemplation and PrEParation steps of the PCC. The most reported barriers were lack of PrEP awareness (n = 16), knowledge (n = 19), willingness (n = 16), and access to a PrEP provider (n = 16), whereas the more reported facilitators were prior HIV testing (n = 8), agency and self‐care (n = 8). All but three identified factors were at the patient rather than provider or structural level.ConclusionsThis review highlights that the bulk of the scientific literature focuses on MSM and on patient‐level factors. Future research needs to ensure underserved populations are included and prioritized (e.g. ethnicity and gender minorities, people who inject drugs) and provider and structural factors are investigated.
Missed Nursing Care as a Mediator in the Relationship between Career Calling and Turnover Intention
Authors: Li Cuicui , Cui Xiaowen , Zhao Yarui , Xin Ying , Pan Weiwei , Zhu Yun 
Published: April 2023

AbstractAimTo explore the role of missed nursing care in mediating the relationship between career calling and intention to leave among nurses.IntroductionIncreasing nurse turnover is still a major concern in the global healthcare system. The most reliable indicator of turnover is turnover intention. It is crucial to understand its affecting elements to suggest measures to lower nurses’ turnover intention.BackgroundTurnover intention has been linked to career calling and missed nursing care. Little empirical research has investigated the possibility that missed nursing care mediates between career calling and turnover intention.MethodsA cross‐sectional survey of 347 nurses was conducted. The survey instruments included the General Information Questionnaire, Calling Scale, Missed Nursing Care Scale and Turnover Intention Questionnaire. Structural equation models were used to build the model. This study made use of the STROBE checklist.ResultsFor 43.8% of nurses, turnover intention was high or very high. Missed nursing care and turnover intention were negatively correlated with career calling. Missed nursing care and turnover intention were positively related. Missed nursing care mediated the relationship between career calling and turnover intention.DiscussionCareer calling and missed nursing care can both influence turnover intention. Career calling can reduce the likelihood of turnover by preventing missed nursing care.ConclusionMissed nursing care mediated the relationship between career calling and intention to leave.Implications for nursing and nursing policyNursing managers should improve nurses’ career calling through professional education and minimize missed nursing care by using electronic nursing reminder devices to reduce turnover intention.
Russia in Latin America: Why support Venezuela in a crisis?
Authors: Thoene Ulf , García Alonso Roberto , Dávila Benavides Diego E. , Roa Sánchez Paula A. , Cuestas Zamora Edgard 
Published: April 2023

AbstractRussia has been a powerful ally in Venezuela's complex crisis, having developed political, economic and cultural relations with the Venezuelan state by employing various foreign policy instruments such as mutual support in multilateral fora, foreign aid, loans, commodity trading, military support and cultural diplomacy. What explains this support, despite Venezuela's severe political and economic crisis? Different perspectives have contributed to discussions on shifts in Russian foreign policy towards Latin America since the end of the Cold War. However, studies subscribing to traditional international relations theories have occasionally focused on a single issue or dimension. Such a focus may be problematic when analysing the multifaceted portfolio applied to Russian foreign policy. Based on the Two‐Good Theory approach, its focus on change and maintenance of the status quo, and the concept of substitutability, this research paper elaborates on Russia's foreign policy strategy towards Venezuela to explain policy priorities by examining the alliance with the Venezuelan Maduro regime. Furthermore, the paper highlights the link between the tangible characteristics of energy security and arms sales and intangible aspects, such as cultural diplomacy, which are important explanatory factors of Russian support for Venezuela.
Integrating presence‐only and presence–absence data to model changes in species geographic ranges: An example in the Neotropics
Authors: Grattarola Florencia , Bowler Diana E. , Keil Petr 
Published: April 2023

AbstractAimAnthropogenic changes such as land use and climate change affect species' geographic ranges, causing range shifts, contractions, or expansions. However, data on range dynamics are insufficient, heterogeneous, and spatially and temporally biased in most regions. Integrated species distribution models (IDMs) offer a solution as they can complement good quality presence‐absence data with opportunistically collected presence‐only data, simultaneously accounting for heterogeneous sampling effort. However, these methods have seen limited use in the estimation of temporal change of geographic ranges and are not yet widespread as they have a steep learning curve. Here we present a generalisable model and case example.LocationNeotropics ‐ Latin America.Taxon
Herpailurus yagouaroundi.
MethodsUsing data on presence‐absence and presence‐only on the jaguarundi (Herpailurus yagouaroundi), we modelled the species distribution at two time periods (2000–2013 and 2014–2021) using a Bayesian model based on Poisson point process in JAGS. Our model integrates the different data types while accounting for varying sampling effort and spatial effect. We predicted the species range at the two time periods and quantified their changes.ResultsBetween the two time periods, the jaguarundi has contracted its southern and northern range limits towards the equator but expanded its area of distribution over the entire species' range. Also, our results show that modelled geographic range, of either time period, is not entirely consistent with the current expert range map from IUCN.Main ConclusionsOur modelling approach provides a working example with the potential to address data gaps and biases in other taxa and regions. Given the increasing number of incidental data being generated by community‐derived initiatives in Latin America, IDMs can become a valuable source for species distribution modelling in the region. This is the first application of the IDM approach with temporal dimension and over the entire species' geographic range.
Assessment of awake bruxism and oral mucosa indentation in adolescents
Authors: Schappo Cláudia , Garanhani Roberto Ramos , Cordeiro Maria Eugênia Wegner , Oppitz Layza Rossatto , Schneider Neblyssa Ágatha , Tanaka Orlando Motohiro , Arantes Ana Carolina Mastriani , Ignácio Sérgio Aparecido , Alanis Luciana Reis Azevedo , Stuginski‐Barbosa Juliana , Camargo Elisa Souza 
Published: April 2023

AbstractBackgroundOral mucosa indentations can be signs of awake bruxism (AB) in adults, but this association has not yet been verified in adolescents.ObjectivesTo evaluate the frequency of AB in adolescents and determine whether there is an association between AB and oral mucosa indentation.MethodsThis study enrolled 66 high school students, mean age of 16.9 (±0.54) years. Clinical inspection was performed to assess the presence or absence of tongue, cheek and lip mucosa indentation. AB was assessed by the Ecological Momentary Assessment method using the WhatsApp mobile app. Messages were sent 15 times a day, 7 days, between 8:00 AM and 7:00 PM at random times to choose one of the five oral behaviours: teeth contact, teeth clenching, teeth grinding, mandible bracing and relaxed jaw muscles. The non‐parametric Mann–Whitney U‐test for independent samples, Friedman test for paired samples, Friedman pairwise multiple comparisons non‐parametric test, Pearson's chi‐squared tests, and z‐test of comparisons between two proportions were performed (p < .05).ResultsDuring the week the frequency of AB behaviours was 56.20%, teeth contact was the most frequent (37.68% ± 22.26%), significantly more frequent than other AB behaviours; there was a greater frequency of cheek indentation (27.27%) and no difference between genders in oral behaviours and indentations (p > .05). A higher frequency of AB behaviours was observed in individuals with a greater frequency of cheek indentation (p < .05).ConclusionsTeeth contact and cheek indentation were the most frequent conditions among adolescents and AB behaviours are associated with this indentation.
Attack of the clones: Population genetics reveals clonality of Colletotrichum lupini, the causal agent of lupin anthracnose
Authors: Alkemade Joris A. , Baroncelli Riccardo , Messmer Monika M. , Hohmann Pierre 
Published: April 2023

AbstractColletotrichum lupini, the causative agent of lupin anthracnose, affects lupin cultivation worldwide. Understanding its population structure and evolutionary potential is crucial to design successful disease management strategies. The objective of this study was to employ population genetics to investigate the diversity, evolutionary dynamics, and molecular basis of the interaction of this notorious lupin pathogen with its host. A collection of globally representative C. lupini isolates was genotyped through triple digest restriction site‐associated DNA sequencing, resulting in a data set of unparalleled resolution. Phylogenetic and structural analysis could distinguish four independent lineages (I–IV). The strong population structure and high overall standardized index of association (r̅d) indicates that C. lupini reproduces clonally. Different morphologies and virulence patterns on white lupin (Lupinus albus) and Andean lupin (Lupinus mutabilis) were observed between and within clonal lineages. Isolates belonging to lineage II were shown to have a minichromosome that was also partly present in lineage III and IV, but not in lineage I isolates. Variation in the presence of this minichromosome could imply a role in host–pathogen interaction. All four lineages were present in the South American Andes region, which is suggested to be the centre of origin of this species. Only members of lineage II have been found outside South America since the 1990s, indicating it as the current pandemic population. As a seedborne pathogen, C. lupini has mainly spread through infected but symptomless seeds, stressing the importance of phytosanitary measures to prevent future outbreaks of strains that are yet confined to South America.