bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expected reasons for leaving the labour market and loss of paid employment among older workers: prospective cohort study
Authors: Sundstrup Emil , Meng Annette , Skovlund Sebastian Venge , Albertsen Karen , Andersen Lars L. 
Published: March 2023

Abstract
Background
Surveying expected reasons for retirement may be a useful strategy to maintain labor market affiliation. The aim was to investigate the prospective association between self-reported expected reasons for leaving the labour market and subsequent loss of paid employment before the state pension age among older workers.

Methods
The prospective risk of loss of paid employment before the official state pension age was estimated from expected reasons for leaving the labour market among 10,320 currently employed older workers (50–63 years) from the SeniorWorkingLife study. In 2018, participants replied to 15 randomly ordered questions about expected reasons for leaving the labour market and were in 2020 followed in a national register containing information on labour market participation.

Results
Loss of paid employment before state pension age was predicted by expected reasons related to ‘Health, work demands and occupational well-being’: ‘Poor physical health’ (RR 1.47, 95% CI 1.45–1.49), ‘Poor mental health’ (RR 1.36, 95% CI 1.32–1.40), ‘Not being capable of doing the job’ (RR 1.20, 95% CI 1.18–1.22), and ‘Not thriving at the workplace’ (RR 1.14, 95% CI 1.11–1.17). Expected reasons related to the possibility of receiving voluntary early retirement benefits also increased this risk. Expected reasons related to ‘Leisure’ (‘Wish for more self-determination’; ‘Wish for more time for hobbies’), ‘Economy’ (‘Economic considerations’; ‘Possibility of receiving pension’), and ‘Norms’ (‘Retirement norms’; ‘To make space for younger employees’) decreased the risk of loss of paid employment before state pension age. Age-stratified analyses revealed that expected reasons related to the domain of ‘Health, work demands and occupational well-being’ predicted risk of loss of paid employment to a greater extent among workers aged 50–55 compared to those aged 56–63.

Conclusions
Expected reasons for leaving the labour market predicted actual labour market participation among older workers in Denmark. Expected reasons related to poor physical and mental health, and not being capable of doing the job seem to be stronger PUSH-factors among workers aged 50–55 compared to those aged 56–63. Preventing early labour market detachment should take the worker’s expected reasons for leaving into account.
The cardiovascular and renal effects of glucagon-like peptide 1 receptor agonists in patients with advanced diabetic kidney disease
Authors: Lin Yuan , Wang Te-Hsiung , Tsai Ming-Lung , Wu Victor Chien-Chia , Tseng Chin-Ju , Lin Ming-Shyan , Li Yan-Rong , Chang Chih-Hsiang , Chou Tien-Shin , Tsai Tzu-Hsien , Yang Ning-I , Hung Ming-Jui , Chen Tien-Hsing 
Published: March 2023

Abstract
Background
To determine whether glucagon-like peptide 1 receptor agonists (GLP-1RAs) have cardiovascular and renal protective effects in patients with advanced diabetic kidney disease (DKD) with an estimated glomerular filtration rate (eGFR) < 30 mL/min per 1.73 m2.

Methods
In this cohort study, patients with type 2 diabetes mellitus and eGFR < 30 mL/min per 1.73 m2 with a first prescription for GLP-1RAs or dipeptidyl peptidase 4 inhibitors (DPP-4is) from 2012 to 2021 (n = 125,392) were enrolled. A Cox proportional hazard model was used to assess the cardiorenal protective effects between the GLP-1RA and DDP-4i groups.

Results
A total of 8922 participants [mean (SD) age 68.4 (11.5) years; 4516 (50.6%) males; GLP-1RAs, n = 759; DPP-4is, n = 8163] were eligible for this study. During a mean follow-up of 2.1 years, 78 (13%) and 204 (13.8%) patients developed composite cardiovascular events in the GLP-1RA and DPP-4i groups, respectively [hazard ratio (HR) 0.88, 95% confidence interval CI 0.68–1.13]. Composite kidney events were reported in 134 (38.2%) and 393 (44.2%) patients in the GLP-1RA and DPP-4i groups, respectively (subdistribution HR 0.72, 95% CI 0.56–0.93).

Conclusions
GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.
The Mental Imagery for Suicidality in Students Trial (MISST): study protocol for a feasibility randomised controlled trial of broad-minded affective coping (BMAC) plus risk assessment and signposting versus risk assessment and signposting alone
Authors: Taylor Peter James , Duxbury Paula , Moorhouse Jane , Russell Chloe , Pratt Dan , Parker Sophie , Sutton Chris , Lobban Fiona , Drake Richard , Eccles Steve , Ryder David , Patel Rafeea , Kimber Elizabeth , Kerry Eirian , Randles Nathan , Kelly James , Palmier-Claus Jasper 
Published: March 2023

Abstract

Background
Going to university is an important milestone in many people’s lives. It can also be a time of significant challenge and stress. There are growing concerns about mental health amongst student populations including suicide risk. Student mental health and counselling services have the potential to prevent suicide, but evidence-based therapies are required that fit these service contexts. The Broad-Minded Affective Coping intervention (BMAC) is a brief (6 sessions), positive imagery-based intervention that aims to enhance students access to past positive experiences and associated emotions and cognitions. Pilot data provides preliminary support for the BMAC for students struggling with suicidal thoughts and behaviours, but this intervention has not yet been evaluated in the context of a randomised controlled trial (RCT). The Mental Imagery for Suicidality in Students Trial (MISST) is a feasibility RCT that aims to determine the acceptability and feasibility of evaluating the BMAC as an intervention for university students at risk of suicide within a larger efficacy trial. Key feasibility uncertainties have been identified relating to recruitment, retention, and missing data. Intervention acceptability and safety will also be evaluated.

Method
MISST is a feasibility randomised controlled trial design, with 1:1 allocation to risk assessment and signposting plus BMAC or risk assessment and signposting alone. Participants will be university students who self-report experiences of suicidal ideation or behaviour in the past 3 months. Assessments take place at baseline, 8, 16, and 24 weeks. The target sample size is 66 participants. A subset of up to 20 participants will be invited to take part in semi-structured qualitative interviews to obtain further data concerning the acceptability of the intervention.

Discussion
The BMAC intervention may provide an effective, brief talking therapy to help university students struggling with suicidal thoughts that could be readily implemented into university student counselling services. Depending on the results of MISST, the next step would be to undertake a larger-scale efficacy trial.

Trial registration
The trial was preregistered (17 December 2021) on ISRCTN (ISRCTN13621293) and ClinicalTrials.gov (NCT05296538).
Individualized medicine using 3D printing technology in gynecology: a scoping review
Authors: Cooke Carly M. , Flaxman Teresa E. , Sikora Lindsey , Miguel Olivier , Singh Sukhbir S. 
Published: March 2023

Abstract
Objective
Developments in 3-dimensional (3D) printing technology has made it possible to produce high quality, affordable 3D printed models for use in medicine. As a result, there is a growing assessment of this approach being published in the medical literature. The objective of this study was to outline the clinical applications of individualized 3D printing in gynecology through a scoping review.

Data sources
Four medical databases (Medline, Embase, Cochrane CENTRAL, Scopus) and grey literature were searched for publications meeting eligibility criteria up to 31 May 2021.

Study eligibility criteria
Publications were included if they were published in English, had a gynecologic context, and involved production of patient specific 3D printed product(s).

Study appraisal and synthesis methods
Studies were manually screened and assessed for eligibility by two independent reviewers and data were extracted using pre-established criteria using Covidence software.

Results
Overall, 32 studies (15 abstracts,17 full text articles) were included in the scoping review. Most studies were either case reports (12/32,38%) or case series (15/32,47%). Gynecologic sub-specialties in which the 3D printed models were intended for use included: gynecologic oncology (21/32,66%), benign gynecology (6/32,19%), pediatrics (2/32,6%), urogynecology (2/32,6%) and reproductive endocrinology and infertility (1/32,3%). Twenty studies (63%) printed 5 or less models, 6/32 studies (19%) printed greater than 5 (up to 50 models). Types of 3D models printed included: anatomical models (11/32,34%), medical devices, (2/32,6%) and template/guide/cylindrical applicators for brachytherapy (19/32,59%).

Conclusions
Our scoping review has outlined novel clinical applications for individualized 3D printed models in gynecology. To date, they have mainly been used for production of patient specific 3D printed brachytherapy guides/applicators in patients with gynecologic cancer. However, individualized 3D printing shows great promise for utility in surgical planning, surgical education, and production of patient specific devices, across gynecologic subspecialties. Evidence supporting the clinical value of individualized 3D printing in gynecology is limited by studies with small sample size and non-standardized reporting, which should be the focus of future studies.
Subcutaneous extension of perigraft seroma after thoracic aortic surgery — report of three cases
Authors: Doita Tsutomu , Yamasumi Taro , Nakamura Yuki , Kondoh Haruhiko 
Published: March 2023

Abstract
Background
Subcutaneous extension of a perigraft seroma following thoracic aortic surgery is an infrequently encountered complication. For treatment, it is necessary to first exclude the possibility of perigraft fluid collection secondary to infection, a pseudoaneurysm, or impending rupture. However, it is difficult to diagnose collected fluid as indicative of a perigraft seroma, and there is also no standardized treatment for this condition.

Case presentation
Three patients who had undergone graft replacement of a thoracic aorta with arch reconstruction were referred to our department for findings of a subcutaneous tumor. In each, computed tomography showed perigraft fluid accumulation in the posterior sternum. In one, a subcutaneous tumor had appeared in the center area of the median sternotomy, 4 months after the operation. It was considered that a wound infection was the likely cause; thus, negative pressure wound therapy was started after incisional drainage and debridement. However, a fever developed 14 days after debridement, resulting in mediastinitis, the latter of which was assumed to be caused by a retrograde infection of the incisional wound. In the other two cases, a subcutaneous tumor appeared in the center of the median area of the sternotomy at 3 and 4 months, respectively, after the operation. In both, the tumor was treated with continuous drainage by aspiration with negative pressure, and cultures of drainage samples were negative for infection. Neither patient had a fever during hospitalization, and fluid collection disappeared during follow-up. In one of the latter two cases, a subcutaneous tumor formed again 3 months after drainage, which was treated in the same manner and subsequently disappeared. Thereafter, there was no recurrence noted at the 3-year follow-up examination.

Conclusion
A perigraft seroma following thoracic aortic surgery, an infrequently encountered complication, has an appearance is similar to a subdermal tumor. Continuous aspiration drainage is a useful option for patients with no fever and negative for infection in drainage culture results.
Arterial Stiffness in Transgender Men Receiving Long-term Testosterone Therapy
Authors: Cunha Flávia Siqueira , Bachega Tania Aparecida Sartori Sanchez , Costa Elaine Maria Frade , Brito Vinicius Nahime , Alvares Leonardo Azevedo , Costa-Hong Valéria Aparecida , Verardino Renata Gomes Sanches , Sircili Maria Helena Palma , Mendonça Berenice Bilharinho de , Bortolotto Luiz Aparecido , Domenice Sorahia 
Published: March 2023

AbstractContextThe effects of androgen therapy on arterial function in transgender men (TM) are not fully understood, particularly concerning long-term androgen treatment.ObjectiveTo evaluate arterial stiffness in TM receiving long-term gender-affirming hormone therapy by carotid–femoral pulse wave velocity (cf-PWV).MethodsA cross-sectional case–control study at the Gender Dysphoria Unit of the Division of Endocrinology, HC-FMUSP, Sao Paulo, Brazil. Thirty-three TM receiving intramuscular testosterone esters as regular treatment for an average time of 14 ± 8 years were compared with 111 healthy cisgender men and women controls matched for age and body mass index. Aortic stiffness was evaluated by cf-PWV measurements using Complior device post-testosterone therapy. The main outcome measure was aortic stiffness by cf-PWV as a cardiovascular risk marker in TM and control group.ResultsThe cf-PWV after long-term testosterone therapy was significantly higher in TM (7.4 ± 0.9 m/s; range 5.8-8.9 m/s) than in cisgender men (6.6 ± 1.0 m/s; range 3.8-9.0 m/s, P &lt; .01) and cisgender women controls (6.9 ± .9 m/s; range 4.8-9.1 m/s, P = .02). The cf-PWV was significantly and positively correlated with age. Analysis using blood pressure as a covariate showed a significant relationship between TM systolic blood pressure (SBP) and cf-PWV in relation to cisgender women but not to cisgender men. Age, SBP, and diagnosis of hypertension were independently associated with cf-PWV in the TM group.ConclusionThe TM group on long-term treatment with testosterone had higher aging-related aortic stiffening than the control groups. These findings indicate that aortic stiffness might be accelerated in the TM group receiving gender-affirming hormone treatment, and suggest a potential deleterious effect of testosterone on arterial function. Preventive measures in TM individuals receiving testosterone treatment, who are at higher risk for cardiovascular events, are highly recommended.
Intranasal Treatment of Acute Rhinosinusitis - Recommendations, Efficacy and Safety
Authors: Sadlik Maria , Abod Leila , Ilnicka Natalia , Matyja Daria , Zuziak Patrycja 
Published: March 2023

Introduction and purpose: Acute rhinosinusitis is a common condition worldwide, usually caused by respiratory viruses. Nasal epithelium is their primary point of entry and an active responder to the infection. Therefore, it seems reasonable for the treatment approach to include locally applied drugs. Our purpose is to bring forward up-to-date recommendations of intranasal treatment options for acute rhinosinusitis, and assess their efficacy and safety.
Description of the state of knowledge: Rhinosinusitis is an inflammation of the mucosa present in the nose and the paranasal sinuses. It affects many patients yearly, bearing significant adverse effects on quality of life, productivity and healthcare expenditure. Acute rhinosinusitis lasts less than 12 weeks and is divided into viral, post-viral and acute bacterial rhinosinusitis. It is one of the prevailing reasons for unfounded antibiotics prescription, although it is usually self-limiting. Its treatment depends on the clinical stage of the infection, however, each of them encloses medications administered intranasally. Based on EPOS2020 and scientific publications it seems that nasal decongestants may be prescribed in viral rhinosinusitis, nasal corticosteroids in post-viral rhinosinusitis and nasal saline can prove beneficial in all clinical stages of rhinosinusitis. While used appropriately all aforementioned medications prove to be safe.
Conclusions: In the light of the findings presented in this paper, it can be concluded that acute rhinosinusitis should be treated not only with oral, but also with intranasal drugs. Nasal decongestants are to be considered in viral rhinosinusitis mainly. Nasal corticosteroids show some positive effect in post-viral rhinosinusitis. Nasal saline can be administered in all clinical stages of acute rhinosinusitis. It is crucial to caution the patients against misuse of the medications, in order to prevent their adverse effects.
Extracorporeal shockwave therapy for diabetic foot ulcers: a feasibility study
Authors: Hitchman Louise H , Totty Joshua P , Cai Paris , Smith George E , Carradice Daniel , Chetter Ian C 
Published: March 2023

Objective:The purpose of this study was to assess the feasibility of delivering extracorporeal shockwave therapy (ESWT) to patients with diabetic foot ulcers (DFUs). It also aimed to explore any potential clinical effect of ESWT on wound healing and investigate whether ESWT offers any patient-reported benefits.Method:In this single-centre, mixed methods feasibility study, patients with a DFU who met the eligibility criteria underwent ESWT three times over a seven-day period. Primary outcome was feasibility of delivering the intervention. Secondary outcomes included wound size, number of DFUs healed at 12 weeks and quality of life (QoL). Semi-structured interviews explored participants' experience of undergoing ESWT.Results:Of 106 patients screened, 24 (22.6%) were recruited. Following recruitment, two patients were withdrawn from the study with 22 patients included in the final analysis. The mean attendance at clinic was 90.9% and 65.1% for follow-up. The mean score for acceptability and tolerability was 9.86±0.48 (95% confidence interval (CI): 9.62–10.01) and 9.15±2.57 (95% CI: 7.87–10.42), respectively. There were no serious adverse events or side-effects. Of the DFUs, 45.5% healed during follow-up and QoL scores improved until eight weeks. Key themes identified from the qualitative interviews were: desire for fast healing; improved QoL; flexibility of new treatments; and accessibility of transport.Conclusion:This study has shown that it is possible to recruit and retain patents into a single-arm study of ESWT for DFUs. This study supports development of a large randomised control trial to determine the clinical and cost-effectiveness of ESWT for DFU healing.
Looking beyond ‘couple’: exploring the relationship between co-conductors facilitating experiential groups for psychodynamic psychotherapy students
Authors: Dudley Jane , Caton Mike 
Published: March 2023

The authors, whose trainings include as group analytic psychotherapists, use the theoretical framework of group analysis to facilitate experiential small and median groups for students on trainings in individual psychodynamic psychotherapy. Even though in group analytic practice it would usually be a definite no, the authors found themselves debating whether members who revealed they were a couple in the past could in fact be together in a group. This discussion prompted the authors to reflect closely on their co-facilitator relationship, causing them to consider what they understood by ‘couple’.
It offered up an opportunity (previously unconscious) to explore the binary fixing of conductors as male/female and heterosexual, and whether such fixing may be a defence by the group, including the group conductors, against allowing and exploring a more fluid, nuanced exploration of gender and sexuality. The authors propose that instead of small experiential groups, co-conducted median groups may offer a richer opportunity for such exploration.
An intrauterine cavity morcellator: A novel approach to high volume uterus morcellation. Ex-vivo study
Authors: Pomeranz Meir , Schonman Ron , Yagur Yael , Tamir Yaniv Rina , Klein Zvi , Daykan Yair 
Published: March 2023

Objective
Uterine size is one of the essential factors determining the feasibility of a minimally invasive gynecologic surgery approach. A traditional electromechanical morcellator is a well-known tool but not without flaws. We aim to assess feasibility and safety of a novel intrauterine power morcellation device for uterine size reduction to overcome these limitations during hysterectomy.

Methods
This single-arm, observational study was conducted in a single tertiary care medical center from April 2022 to July 2022. Feasibility and safety of a novel intrauterine morcellation device for uterine size reduction was tested in ten post-hysterectomy uteri (Ex-vivo).

Measurements and main results
Ten uteri were examined in this trial. No major complications occurred during the procedure. All ten (10) uteri were successfully reduced in size (size reduction range was between 9% to 54%). The average resection time using the Heracure Device was 4.3 minutes (range: 1min– 10min). Mean uterus weight reduction was 21%, with a mean circumference reduction of 25%. No leakage was observed from the outer surface of the uterus/serosa after the saline injection post-procedure examination.

Conclusion
In this novel experiment, we verified the feasibility and safety of the Heracure device for vaginal intra-uterine morcellation for uterine size reduction. This technique could enable rapid and easy removal of the uterus through the vaginal orifice.

Clinical trial registration
Name of the registry: ClinicalTrials.gov; Number Identifier: NCT05332132.
Psychosocial resources predict frequent pain differently for men and women: A prospective cohort study
Authors: Samulowitz Anke , Haukenes Inger , Grimby-Ekman Anna , Bergman Stefan , Hensing Gunnel 
Published: March 2023

Introduction
Psychosocial resources, psychological and social factors like self-efficacy and social support have been suggested as important assets for individuals with chronic pain, but the importance of psychosocial resources for the development of pain is sparsely examined, especially sex and gender differences. The aim of this study was to investigate associations between psychosocial resources and sex on the development of frequent pain in a general population sample, and to deepen the knowledge about sex and gender patterns.

Methods
A sample from the Swedish Health Assets Project, a longitudinal cohort study, included self-reported data from 2263 participants, 53% women, with no frequent pain at baseline. The outcome variable was frequent pain at 18–months follow-up. Psychosocial resources studied were general self-efficacy, instrumental and emotional social support. Log binomial regressions in a generalised linear model were used to calculate risk ratios (RRs), comparing all combinations of men with high psychosocial resources, men with low psychosocial resources, women with high psychosocial resources and women with low psychosocial resources.

Results
Women with low psychosocial resources had higher risk of frequent pain at follow-up compared to men with high resources: general self-efficacy RR 1.82, instrumental social support RR 2.33 and emotional social support RR 1.94. Instrumental social support was the most important protective resource for women, emotional social support was the most important one for men. Results were discussed in terms of gender norms.

Conclusions
The psychosocial resources general self-efficacy, instrumental and emotional support predicted the risk of developing frequent pain differently among and between men and women in a general population sample. The results showed the importance of studying sex and gender differences in psychological and not least social predictors for pain.