bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Application of Automated Logistics System Based on Deep Learning Algorithm
Authors: Liu Shujing , Niu Chungang 
Published: July 2023

Abstract
With the rapid development of smart cars, environmental perception and scene understanding have strong auxiliary functions for smart cars. According to the technical requirements of the modern logistics road scene segmentation management system, this paper applies the image segmentation algorithm module to the management system. The system introduces the intelligent assisted driving management system, and takes the road scene segmentation management system as the core module of the management system. The system can analyze road conditions signals on the road section to ensure the safety of drivers during the delivery of goods. At the same time, according to the characteristics of the freight site, the product design is completed as an Android intelligent freight platform application. All module systems in the system are explained and presented in more detail. The application field directly refers to the online operation of the traditional logistics distribution chain to improve the efficiency of the logistics and freight chain. By embedding the above-mentioned intelligent assisted driving management system into this application field, the entire cargo transportation chain becomes safer and faster.
Diagnosis of Splenic Marginal Zone Lymphoma by Ultrasound and Contrast- enhanced ultrasound: A Case Report and literature review
Authors: Zhang Xu , Lu Jianghao , Hao Yanli , Wu Tingting , Gao Zeyan , Zhou Peng 
Published: July 2023

Abstract
Background:
Splenic marginal zone lymphoma (SMZL) is an extremely rare indolent B-cell lymphoma originating in the spleen, whose clinical detection is difficult. Ultrasound is one of the first methods of clinical routine spleen examination and regular review. Meanwhile, ultrasound contrast examination can clearly show the blood perfusion pattern of spleen tissues and lesions, and provide help for the differential diagnosis of spleen tumor lesions. The ultrasound and contrast-enhanced ultrasound manifestations of SMZL are rarely reported.
Case presentation:
Patient, female, 65 years old，came to the hospital with an enlarged spleen. Laboratory examination in our hospital showed that the lymphocyte count was reduced to 0.54×109/L, the lymphocyte ratio was 0.153. Ultrasonographic findings showed that the spleen was enlarged, with diffuse thickening of parenchymal echo, uneven distribution, in the shape of zonal or grid. There was a mass at the hilum of the spleen. After the infusion of contrast agent Sonovue, the tumor regression was delayed and the overall enhancement pattern was slow in and fast out. Combined with contrast-enhanced ultrasound, the final diagnosis was spleen enlargement with splenic mass, lymphoma? On CT images, the spleen was enlarged and unevenly distributed, and two isodense enhanced foci were observed in the spleen. Pathological findings of bone marrow aspiration in patients: CD20(+), CD3(-), CD138(-), CD38(-) bone marrow hyperplasia was slightly reduced.
The patient underwent laparoscopic splenectomy under general anesthesia. Postoperative gross observation showed that the spleen was enlarged and intact. A hard gray nodule with clear boundary was seen in the spleen. Light microscopy showed diffuse proliferation of tumor cells. Immunohistochemical: CD20 (air +), CD3 (-), the BCL - 2 (air +), the BCL - 6 (-), CD10 (-), CD43 (-), CyclinD1 (-), CD21 (-), CD23 (-), Ki67 (+ 8%). Combined with immunomarkers, it was considered as splenic marginal B-cell lymphoma. The tumor invaded two lymph nodes at the splenic hilum.
Conclusion:
SMZL is rare and difficult early diagnosis due to its insidious symptoms, slow progression. Ultrasound and contrast-enhanced ultrasound can improve the diagnostic rate of SMZL. In this case, ultrasound and contrast-enhanced ultrasound mode can provide reference for clinical ultrasonic diagnosis of SMZL.
Application of Improvement Fuzzy Logic Technique in Groundwater Quality Assessment in Naiman Banner
Authors: Ma Shimin , DAI Yajian , TIAN Hui , JIANG Shan , SUN Jiaquan 
Published: July 2023

Abstract
At present, many fuzzy logic techniques have been developed, however, there is a lack of studies concerning the application of improved techniques to evaluate groundwater quality in comparison to traditional methods. In this study, a set of sample data for nine items (total hardness, total dissolved solids, SO43−, NO3−, total Fe, F−, Pb, pH, and turbidity) was adopted for developing an improved fuzzy logic technique in order to evaluate groundwater quality status. The evaluation results were classified into five grades according to a standard for groundwater quality(GB/T 14848 − 2017), to determine the suitability groundwater use. The results showed that the quality of the groundwater samples was mostly within Grades 1 and 2, making the water suitable for a variety of uses. Traditional analysis found the groundwater quality was mostly within Grade 5. Improved fuzzy logic techniques were shown to be helpful for future research related to groundwater quality evaluation.
Robotic-assisted total knee arthroplasty improved component alignment in the coronal plane compared with navigation-assisted total knee arthroplasty: a comparative study
Authors: Omichi Yasuyuki , Hamada Daisuke , Wada Keizo , Tamaki Yasuaki , Shigekiyo Shota , Sairyo Koichi 
Published: July 2023

Abstract
Background
The purpose of this study was to directly compare implant placement accuracy and postoperative limb alignment between robotic-assisted total knee arthroplasty and navigation-assisted total knee arthroplasty.
Methods
This retrospective case-control study included a consecutive series of 182 knees (robotic-assisted group, n = 103 knees; navigation-assisted group, n = 79). An image-free handheld robotic system (NAVIO) or an image-free navigation system (Precision N) was used. Component and limb alignment were evaluated on three-dimensional computed tomography scans and full-length standing anterior–posterior radiographs. We compared the errors between the final intraoperative plan and the postoperative coronal and sagittal alignment of the components and the hip-knee-ankle angle between the two groups.
Results
The orientation of the femoral and tibial components in the coronal plane were more accurate in the robotic-assisted group than in the navigation-assisted group (p < 0.05). There was no significant difference in the orientation of the femoral and tibial component in the sagittal plane between the two groups. There were fewer outliers in the tibial coronal plane in the robotic-assisted group (p < 0.05). There was also no significant difference in the frequency of outlying values for coronal or sagittal alignment of the femoral component or sagittal alignment of the tibial component or the hip-knee-ankle angle between the two groups.
Conclusion
Robotic-assisted total knee arthroplasty using a handheld image-free system improved component alignment in the coronal plane compared with total knee arthroplasty using an image-free navigation system. Robotic surgery helps surgeons to achieve personalised alignment that may result in a better clinical outcome.
The efficacy of tofacitinib combined with bDMARDs in the treatment of ankylosing spondylitis patients with inadequate response to bDMARDs: a retrospective study
Authors: Chang Jie , Wang Gang 
Published: July 2023

Abstract
Introduction: Ankylosing spondylitis(AS) is a chronic inflammatory rheumatic disease primarily affecting the spine and sacroiliac joints. While biologic disease-modifying antirheumatic drugs(bDMARDs) and targeted synthetic DMARDs(tsDMARDs) are popular treatments for AS, there is limited research on their combined use. This study examined a cohort of AS patients who demonstrated inadequate response to bDMARDs and subsequently initiated combination therapy with tofacitinib in conjunction with bDMARDs, assessing both the efficacy and safety profile of this therapeutic approach.
Methods: In this study, we retrospectively collected the electronic medical records (EMR) of 15 adult patients with AS who were admitted to the Fourth Affiliated Hospital Zhejiang University School of Medicine between January 2018 and June 2022. All patients had received at least one bDMARD treatment for more than three months and still exhibited moderate to high disease activity. Tofacitinib 5mg bid was added to their original biological treatment. Treatment was continued for a minimum of 12 weeks following the initiation of combination therapy. Changes in ASDAS-CRP and BASDAI scores at week 12 were collected and analyzed from baseline, while changes in C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) at weeks 4, 8, and 12 were also collected and analyzed.
Results: After 12 weeks of treatment, the overall ASDAS-CRP score decreased significantly from a baseline of 3.82±1.47 (2.83~4.99) to 1.47±0.48 (0.75~2.44), with remission achieved by 7 patients (46.7%) and low disease activity achieved by 5 patients (33.3%). The overall BASDAI score also showed significant improvement, decreasing from a baseline of 5.11±1.42 (3.25~7 .75) to 1.28±0.70(0.20~2.55). Additionally, both ESR and CRP levels decreased significantly during the course of treatment without any reported adverse events leading to discontinuation.
Conclusion: To a certain extent, our findings provide some evidence supporting the efficacy and safety of the combination of bDMARD and JAK inhibitor tofacitinib in AS patients with inadequate response to bDMARD monotherapy. It effectively controls disease activity while maintaining a relatively low and manageable incidence of adverse events. Further prospective randomized controlled trials with large sample sizes are anticipated to provide evidence-based medical support.
Comparative study of a hydraulic, pneumatic and electric linear actuator system
Authors: Pustavrh Jan , Hočevar Marko , Podržaj Primož , Trajkovski Ana , Majdič Franc 
Published: July 2023

Abstract
Different applications or industries use different systems for linear actuation, such as hydraulic, pneumatic, or electric. Electric systems are becoming more popular and are already replacing hydraulic systems in various applications. These are known to be potentially harmful to the environment, as large amounts of fluid can be released into the environment in the case of a pipe failure or other accident. This paper presents the results of a comparison between hydraulic, pneumatic and electric systems under variable conditions but with similar loads in all three systems. The common feature of all three systems is the input power, which was limited to 1.1 kW. There was no hydraulic accumulator in the hydraulic system and no pressure vessel in the pneumatic system, so no stored energy could affect system behaviour or results. The main difference between the observed systems was the displacement and power consumption profile. The smoothest response and the lowest energy consumption was achieved with the electric system, although both hydraulic and pneumatic systems can achieve a smooth response with a few modifications.
Early rhythm control strategy in early atrial fibrillation patients, a retrospective cohort study.
Authors: Liu Yiwei , Chen Xiaowei , Lin Hongbo , Shen Peng , Sun Feng , Xu Yang 
Published: July 2023

Abstract
Introduction: Atrial fibrillation (AF) treatment strategy on whether to use rhythm control or usual care (UC) has been debated for decades. In early studies, these two strategies showed equivalent efficacy, but more recent studies based on CHA2DS2-VASc score indicated that early rhythm control (ERC) would benefit more than UC strategy. We hypothesized that ERC might benefit AF patients in other cardiovascular outcomes, regardless of CHA2DS2-VASc score. To clarify this, we conducted the current study.
Methods: A retrospective cohort study was carried out using the Yinzhou Regional Health Care Database (YRHCD). We included all patients diagnosed with AF within 1 year, while excluding those without age/sex information, no ERC/UC treatment prescription, or with ongoing cancer. The primary outcome was major cardiovascular events (MACE). We used inverse probability of treatment weighting (IPTW) for covariates weighting.
Results: In total, 7,161 patients diagnosed with early AF were included in this study, 2,248 and 4,913 were in ERC group and usual care group, respectively. During mean follow-up period 3.2 years (27,945 person-year), and after IPTW, the result remained similar for ERC showed significantly lower risk for MACE (HR: 0.75[0.61, 0.96], P=0.02), and heart failure (HR: 0.71[0.54,0.95], P=0.01). No significant results were found in stroke, cardiovascular death, or all-cause mortality.
Conclusion: Early rhythm control is more beneficial to early AF patients than usual care for major cardiovascular events.
Recovery of histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection
Authors: Watanabe Ayami , Nakajima Ami , Shiroishi Mitsunori 
Published: July 2023

Abstract
G protein-coupled receptors (GPCRs) are the largest protein family in humans and are drug targets. Yeast, especially Saccharomyces cerevisiae, is a useful host for modifying the function and stability of GPCRs through protein engineering, which is advantageous over mammalian cells. When GPCRs are expressed in yeast, their function is often impaired. In this study, we performed random mutagenesis using error-prone PCR and subsequent in vivo screening to obtain mutants that recovered the activity of the human histamine H3 receptor (H3R), which lost signaling function when expressed in yeast. After screening, four mutations were identified as having recovered activity. Three of these were located near the DRY and NPxxY motifs of the H3R, which are important for activation and commonly found in class A GPCRs. These mutants responded exclusively to the yeast YB1 strain harboring Gi-chimera proteins, showing retention of G protein specificity. Analysis of one of these mutants with recovered activity, C415R, revealed that it maintained its ligand-binding characteristics. The mutations identified in this study may recover the activity of other GPCRs that do not function in S. cerevisiae, and may also be useful in creating mutants, such as stabilized GPCRs in their active conformations.
Internet of Things Sensors and Support Vector machine integrated intelligent irrigation system for agriculture industry
Authors: Kumar G. Kranthi , Bangare Manoj L. , Bangare Pushpa M. , Kumar Chanda Raj , Raj Roop , Arias-Gonzáles José Luis , Omarov Batyrkhan , Mia Md. Solaiman 
Published: July 2023

Abstract

Because there is more demand for freshwater around the world and the world's population is growing at the same time, there is a severe lack of freshwater resources in the central part of the planet. The world's current population of 7.2 billion people is expected to grow to over 9 billion by the year 2050. The vast majority of freshwater is used for things like cooking, cleaning, and farming. Most industrialised countries are in desperate need of smart irrigation systems, which are now a must-have because of how quickly technology is improving. In article presents IoT based Sensor integrated intelligent irrigation system for agriculture industry. IoT based humidity and soil sensors are used to collect soil related data. This data is stored in a centralized cloud. Features are selected by CFS algorithm. This will help in discarding irrelevant data. Clustering of data is performed by K means algorithm. This will help in keeping similar data together. Then classification model is build using the SVM, Random Forest and Naïve Bayes algorithm. Model is trained, validated and tested using the acquired data. Historical soil and humidity related data is also used in training the model. K-means SVM hybrid classifier is achieving better results for classification, prediction of water demand and saving fresh water by intelligent irrigation.
Correlation analysis of serum exosomal miR-133a-3p, miR-206, and miR-549a-3p with diagnosis and prognosis in patients with traumatic head injury
Authors: yang yajun , Wang Yi , Li Panpan , Bai Feirong , Liu Cai , Huang Xintao 
Published: July 2023

Abstract
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Our research team previously used high-throughput sequencing to reveal the significant differences of serum exosomal miR-133a-3p, miR-206, and miR-549a-3p were significantly different from the control group in the severe TBI (sTBI), mild or moderate TBI (mTBI), and control groups. However, there is a lack of convincing experimental evidence. To address this, the present study experimentally sought to verify Our current study verifies the potential of serum exosomes miR-206 and miR-549a-3p as potential biomarkers in TBI patients and their association with inflammatory response and oxidative stress through real-time fluorescence quantification, enzyme-linked immunosorbent assay, and statistical analysis.
Inferior vena cava thrombosis with septic shock case report and literature review
Authors: Dai Jinfeng , Huang Xuan , Feng Tongfei , Li Shangao , Lv Bin 
Published: July 2023

Abstract
This case report provides a detailed description of a middle-aged male patient who presented with fatigue and decreased appetite whose medical history revealed type 2 diabetes mellitus, Whipple surgery and pulmonary tuberculosis. Upon admission, the patient presented with recurrent fever,septic shock and splenomegaly. Extensive diagnostic workup, including blood tests, imaging studies and culture, was performed to investigate the underlying cause. Inferior vena cava septic thrombophlebitis was finally diagnosed. The patient showed improvement and was discharged after receiving a full course of high-dose antibiotics and heparin treatment.
Benefits of Pilates training and Nano-Curcumin supplementation for overweight and obese females with NAFLD
Authors: Rezaei Leila , Ebrahimi Maryam , Shafaghi Afshin , Hojati Amineh 
Published: July 2023

Abstract

Purpose
Non-alcoholic fatty liver disease (NAFLD) is a significant cause of chronic liver disease and a paramount health concern due to its prevalence. According to the available evidence, due to the ineffectiveness of conventional drug therapies, lifestyle changes focusing on nutrition and physical activity have had the most excellent effect on treating this disease. This study investigated the impact of Pilates training and Nano-curcumin in overweight and obese women with NAFLD.
Method
In this semi-experimental, placebo-based study, 12 obese and overweight females with NAFLD (age: 44.33 ± 8.55 years, BMI: 31.76 ± 3.90 kg/m2, WHR > 0.85) participated in Pilates training, three sessions per week for eight weeks with Nano Curcumin (80 mg/day) or placebo supplementation. Anthropometric indices, blood markers and hepatic steatosis were assessed 48 hours before and after 8 weeks of intervention. All data were analyzed in IBM SPSS version 26 (P < 0.05).
Results
WHR (P = 0.002) and LDL/HDL ratio (P = 0.010) improved in individuals consuming Nano curcumin in Pilates protocol. However, Pilates training independent of supplementation improved hepatic steatosis, lowered GGT, and increased HDL levels (P < 0.05).
Conclusion
Pilates training may be helpful for the management of NAFLD, and it probably has more effect on abdominal obesity when combined with Nano curcumin supplementation.
Insights from the preimaginal morphology of the constans species-group, to reveal novel morphological patterns of the Merodon albifrons-evolutionary lineage (Diptera, Syrphidae)
Authors: Aracil Andrea , Andrić Andrijana , Rojo Santos , Shparyk Viktor , Mishustin Ruslan , Popov Grigory , Radenković Snežana , Vujić Ante , Pérez-Bañón Celeste 
Published: July 2023

Abstract
Merodon triangulum Vujić, Radenković & Hurkmans, 2020 is a european endemic hoverfly species belonging to Merodon constans species group, inside albifrons lineage. The distribution of this species is known to be mostly central Europe and Balkan peninsula and it has been categorized as Near Threatened in the European IUCN red list of hoverflies (Janković and Radenković 2021); this paper cites the species for the first time in Ukraine (western Ukraine, specifically). In the present study, the preimaginal stages of this species are described and figured using Scanning Electron Microscopy. The material used for the descriptions were larvae collected in Ukraine and Serbia feeding inside underground storage organs of the plant Leucojum vernum L., 1753. This morphological description constitutes the first one inside the constans species group, and the sixth description of the albifrons lineage, in which there is only one species group left to have at least one species of the preimaginal stages described (ruficornis group). The descriptions were compared with the rest available of the genus, stating the diagnostical characters of the present species and the shared characters inside the lineage. The relationship between preimaginal stages and Leucojum bulbs is stated for the first time for constans species group.
Characterization of Procollagen-lysine, 2-oxoglutarate 5-dioxygenases as Therapeutic Targets in a Pan-Cancer Study
Authors: Liu Weijie , Liu Jiaxi , Deng Junsheng , Zhan Ting , Han Zheng , Tan Jie , Liu Meng , Chen Mengge , tian Xia , Huang Xiaodong 
Published: July 2023

Abstract
Background
Certain members of the Procollagen-lysine 2-oxyglutarate 5-dioxygenase (PLOD) family have been identified to play a role in tumor metastasis and progression.
Materials & Methods
The association between PLOD expression and overall survival (OS) rates was assessed utilizing the Kaplan-Meier survival curve. The correlation between gene expression and patient OS rate was determined utilizing a univariate or multivariate Cox proportional hazards regression model or log-rank test to evaluate the difference in OS rates. The infiltration levels of stromal cells and immune cells in different tumors were analyzed utilizing the stromal-immune-ESTIMATE score.
Results
Our results showed that PLOD1, PLOD2, and PLOD3 were predominantly upregulated in cancer cells, and the expression of PLOD family members frequently correlated with the OS of cancer patients. All PLOD genes exhibited significant associations with immune infiltration subtypes, as well as different levels of stromal cell infiltration and tumor cell stemness. Furthermore, our research demonstrated that the PLOD gene might contribute to drug resistance in cancer cells.
Conclusion
Our study indicated that PLOD was primarily associated with more aggressive cancer characteristics and potentially contributed to tumor metastasis and tumorigenesis, leading to a poorer prognosis.