bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Study: Management of Atopic Dermatitis
Authors: Adji Aryani , Cahyadi Alexandro Ivan 
Published: August 2023

Background: Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by mild to severe itching, relapses, and mostly appears in infants and children. Although there have been current advances in the management of AD, satisfactory treatment has not been achieved. Purpose: To evaluate the treatment of patients with AD in order to provide better management. Methods: A retrospective study of newly diagnosed AD patients at the Allergy and Immunology Division of the Outpatient Unit, Dermatology and Venereology Clinic, Prof. Dr. R.D. Kandou Hospital Manado from 2019-2021. Result: Antihistamines were the most widely prescribed medication, administered to 108 patients of all patients’ visits, and 94 (87%) of them were given cetirizine (the most widely prescribed type). Emollients were used adequately; they included petroleum jelly in 82 patients (90.1%) and urea 10% cream in 9 patients (9.9%). Conclusion: There were 108 AD patients in Dermatology and Venereology Clinic, Prof. Dr. R.D. Kandou Hospital Manado from 2019-2021. Treatment with antihistamine and emollient therapy gave satisfactory results.
EFFECT OF ADDITION RAMIE AND COCONUT COIR FIBERS WITH DIFFERENT CONCENTRATIONS ON TENSILE STRENGTH OF ACRYLIC DENTURE BASE
Authors: Prawesthi Endang , Eka Putri Adinda , Asylla Vilza , Arif Wibowo Sambodo 
Published: August 2023

Background: Acrylic denture base material has advantages such as good aesthetics, ease of repair, and affordable price, but this denture has mechanical properties, one of which is low tensile strength so fractures often occur during use. Utilization of natural fibers such as ramie (Boehmeria Nivea) and coconut coir (Coco Nucifera L) can be used as an alternative reinforcement for acrylic denture bases. Purpose: To determine the effect of adding ramie fiber and coconut coir fiber at different concentrations on the tensile strength of the acrylic denture base. Method: This study used a laboratory experimental method with a flat dumbell-shaped specimen with a size of 75 × 10 × 3 mm based on ISO 527-1 (2019). The specimens consisted of 42 plates which were divided into 7 groups, namely 6 specimens each group without fiber addition (control), with the addition of ramie fiber 1%, 2%, 3%, and the addition of coconut coir fiber 1%, 2%, 3%. Tensile strength testing using Universal Testing Machine (UTM), data were analyzed by One-way ANOVA test and Post Hoc LSD test. Result: The 3% ramie fiber addition group had the highest tensile strength (76.47 MPa), the 1% coconut coir fiber addition group had the lowest tensile strength (58.91 MPa). There was a significant difference in the results of the control group's tensile strength test and the addition of 3% ramie fiber and 1% coconut coir fiber (p-value < 0.05). Conclusion: The greater the concentration of ramie and coconut fiber additions, the higher the tensile strength value, although the tensile strength value in the coconut fiber addition group was lower than the control group and ramie fiber addition.
MOL Pakistan P&A Campaign Review - Lessons Learnt and Takeaways to Deliver Cost Effective P&A Projects
Authors: Ali Aslam , Khan Shahjahan , Anwar Muhammad Waseem , Saleem Ammar Bin , Talha Muhammad Shahzad 
Published: August 2023

Abstract
With the tremendous increase in Plug and Abandonment activities globally, Oil and Gas E&P Companies are opting strategic approach for P&A as per industry regulations and standards. Plug and abandonment of well having integrity issues, typically contributes to 15% - 25% of the cost of drilling exploration well. MOL Pakistan has recently performed an extensive P&A campaign where numerous challenges were encountered. Since, every well is unique, so are the challenges associated with it. This paper discusses the challenges encountered in the P&A of wells along with the methodology and approach to counter the same, optimization of subsequent operations, journey through technological transformation over time in P&A projects and delivering cost effective P&A projects. Most P&A jobs performed, involved restricted accessibility to the wellbore due to broken tubing and completion assemblies in depleted reservoirs with limited information about sand-face and reservoir pressures requiring complex well killing operation and managing/addressing sustained casing pressures (SCP) in multiple annuli.
To achieve excellence in P&A projects delivery and optimising time and cost, systematic methodology was adopted where special emphasis was made on in house expertise development, establishing combined task force with service providers involving their regional teams, discussing problems and lessons learnt with industry P&A experts and finding optimum tools and technology. Communication and reporting being a very important tool in the process, it was ensured that during execution of project, daily meeting, weekly operations forecast, and risk assessment meetings are conducted regularly between field and office operations team to discuss and optimize upcoming operations
As a result successful operations were performed in complex P&A wells involving: retrieval of broken completion strings, retrieval of casing strings based on URS/CBL-VDL recorded in double casing, optimising number of cement plugs while complying to industry standards and requirements; retrieval of casing slips from well head with casing cemented to surface, successfully performing 1st ever application of 13 3/8″ casing pilot milling from the surface in asia pacific to expose annulus and treat sustained casing pressures in multiple annulus. Consequently, Successful P&A projects were delivered with time and cost reduction up to 40% in 2021 as compared to the first P&A project in 2018 by utilizing rigorous lessons learning process implementation.
Journey of Hydraulic Frac Stimulation
Authors: Iqbal F. , Ahmed Q. , Ahmed R. 
Published: August 2023

Abstract
Hydraulic frac, over the last few decades has significantly changed conventional and unconventional resource portfolio. The modern advancement and effective customized use of the technology have done fortune to what was non-producible & non-recoverable hydrocarbon resource. Global industry wide learning curve of hydraulic frac is at a mature stage. However, local industry is still emerging in terms of large-scale application of hydraulic fracturing as stimulation technique.
The early attempts of fracturing in early 90's revealed significant operation challenges due to limited handle around the regional tectonics and after few attempts the formation was deemed to be un-frackable. As part of UEP innovative Technology deployment portfolio, the subject was revisited and through continuous improvement process, significant breakthrough in hydraulic frac technology has been realized.
The paper presents a summary of UEP journey in developing hydraulic frac technology over the years. It summarizes the challenges faced in designing/modelling, execution of treatments and their functional dependence on critical controls ranging from regional tectonic settings to rock/reservoir intrinsic properties. The case studies explain methodologies adopted to unleash tight gas potential, establish tight oil potential, resolve deliverability, and sand production challenges through successful deployment of hydraulic frac activity.
This breakthrough in technology deployment has created a line of sight to exploit and unlock significant contingent resources in UEPL portfolio. The organization is now ready to extend the appraisal activities to a full deployment stage.
Understanding Source of Produced Water with Varying Salinities in Oil and Gas Field of Eastern Potwar, A Case Study
Authors: Khanam Mehwish , Javed Waqar Ali , Nazeer Adeel , Daud Farrukh , Ashraf Zaid , Wahid Farhan , Ali Shahzad 
Published: August 2023

Abstract
X field is producing water along with hydrocarbon from Tobra, Khewra & Sakesar reservoirs. Hence, it is imperative to understand the source of this water and its entry into the wells to optimize the field's production and limit the water production within the available water handling and disposal constraints. Even though multiple wells have been drilled in the field to-date, depth of the free water level is still unknown in the Tobra and Khewra formations. Large uncertainty lies with the thickness of the transition zone across the reservoirs with permeabilities ranging from 4 to 10 md. Besides, capillary forces are likely to have some effect in the rise of water in the pore space leading to some water production. In context of the uncertainties associated with the water breakthrough time and predicting the trend of water cut, it is considered useful to investigate the source of water via the information on the salinities and ion analyses.
Four types of water have been produced from four types of reservoir rocks. Water ranges from fresh to brackish, and brackish to brine. Murree Formation is producing freshwater on surface; and hydrocarbon (HC) shows during drilling. Water production in Sakesar is high with relatively less salinity and high pressures. Surface Well Testing (SWT) data confirmed the water salinity of brine origin with varying composition. Sakesar formation's water salinity in X field ranges between 10,000 - 20,000 ppm is because of fresh water mixing with marine origin. However, nearby regional produced water salinity is 50,000 - 60,000 ppm from Sakesar. SWT data showed the production of high saline water in Tobra and Khewra reservoirs. However, salinity greater than 80,000 ppm is not associated with depositional environment of glacial sands (Tobra), and deltaic sands (Khewra); nor present in present day oceans and seas. Probably high saline water (brine) encroached in the formation from somewhere else.
Our research is based on the chemical testing of water samples collected during well testing campaigns. Data was analyzed to understand the origin of water in Potwar Plateau, X field and probable ranges of salinity in different depositional environment. This case study is focused on the source of water from underlying formations or through deep seated faults. Same will be confirmed by detailed evaluation of SWT data and water analyses. In this paper, water breakthrough will be discussed with varying salinities in different wells depending upon the faults in the vicinity.
Morphological and functional differences of monocyte derived dendritic cells in patients with acute coronary syndrome
Authors: Wang Zhenglong , Ke Changhao , Cheng Yuheng , He Yuanjie , Shi Bei 
Published: August 2023

Abstract
Objective To investigate the morphological and functional differences of monocyte derived dendritic cells in different types of ACS patients.
Methods The peripheral blood mononuclear cells (PBMC) were isolated and differentiated into mononuclear dendritic cells (moDC) which morphology was observed by electron microscope and its related molecules (CD11c, CD14, CD80, CD86, HHLA -DR) were identified by flow cytometry (FCM) and the expression levels of IL6, IL10 and IL12p70 were detected by ELISA in acute coronary syndrome patients with unstable angina (UA), non-ST elevation myocardial infarction (NST), ST elevation myocardial infarction (ST) and healthy control group (CON).
Results (1) FCM showed the moDC surface molecules CD11c and HLA-DR were highly expressed, while CD80 and CD86 were weakly expressed. (2) Electron microscopy showed the DC of UA, NST and ST groups had longer and more dense pseudopods than that of CON group. The expression levels of CD80 and HLA-DR in ST group and NST group were increased, while the expression levels of OVA were decreased compared with CON group and UA group,(p<0.05). (3) The levels of serum IL6 and IL12p70 in ST and NST groups were significantly higher than those in CON and UA groups (p<0.05), but there was no significant difference in the expression level of IL10 among the four groups.
ConclusionsThe morphology and function of moDC in patients with different types of ACS are different. In patients with acute myocardial infarction (AMI), moDC has stronger antigen presenting ability, pro-inflammatory secretion function and weaker phagocytosis ability compared with non-myocardial infarction patients
PHA Production from Molasses Using Mixed Microbial Cultures: Techno-Economic Feasibility AnalysisPHA Production from Molasses Using Mixed Microbial Cultures: Techno-Economic Feasibility Analysis
Authors: Shen Ming-Yan , Souvannasouk Vannasinh , Saipa Sasithorn , Chu Chen-Yeon , Tantranont‬ Nuttiya , sawatdeenarunat Chayanon 
Published: August 2023

Abstract
Today, about 4.8–12.7 million tons of fossil-based plastics have reached the oceans. Thus, this pollution has become a matter of significant concern globally. Polyhydroxyalcanoates (PHAs) are one of the promising biodegradable plastics that could replace conventional petroleum-based plastics and subsequently mitigate oceanic pollution. High organic wastewater has been examined as a potential substrate for lowering the manufacturing cost of PHAs. This study has found that for a project lifetime of 20 years, the cost of the PHA manufacturing process reached $994,143. The annual process operation cost was $159,711. The payback period was 6.79 years, and the internal return rate was 16%. However, if costs increased by 20%, the benefits decreased by 25%. Since price of PHAs is higher than that of conventional plastic, various supports from the government could potentially push PHAs to the market.
Statement of Novelty
This study successfully determines the techno-economic analysis of the PHA production to form high-strength waste using MMC as the microbial source. The sensitivity analysis of the system was also performed.
Real time Analysis of Virtual Reality Art Design Based on Immersive communication
Authors: Liu Liping 
Published: August 2023

Abstract
The traditional indoor virtual reality art design is quite different from the actual placement of items. Based on the perspective of immersive communication, this paper analyzes the specific ways of applying virtual reality technology in art design from the two dimensions of physiological immersion and psychological immersion, so as to analyze the process of Virtual Reality Art Design Based on Immersive communication. The Kinect device is used to collect the indoor spatial feature depth data. After repair and filtering, the processed data is converted into the data in the spatial coordinate system to build the geometric model of the spatial feature data. This paper analyzes the indoor virtual reality art design by using virtual reality technology. The experiment proves that the placement error of the indoor virtual reality artistic achievements is small.
Vascular ATGL-dependent lipolysis protects endothelial function against exogenous lipids overload; involvement of endogenous cPLA2–PGI2 pathway
Authors: Sternak Magdalena , Stojak Marta , Banasik Tomasz , Kij Agnieszka , Bar Anna , Pacia Marta Z , Wojnar-Lason Kamila , Chorazy Natalia , Mohaissen Tasnim , Marczyk Brygida , Czyzynska-Cichon Izabela , Mika Adriana , Chlopicki Stefan 
Published: August 2023

Abstract
Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays detrimental pathophysiological role in cardio-metabolic diseases. However, the organo-protective effects of ATGL-induced lipolysis were also suggested. The aim of this work was to characterize the function of lipid droplets (LDs) and ATGL-induced lipolysis in the regulation of endothelial function. ATGL-dependent LDs hydrolysis and cytosolic phospholipase A2 (cPLA2)-derived eicosanoids production were studied in the aorta, endothelial and smooth muscle cells exposed to exogenous oleic acid (OA) or arachidonic acid (AA). Functional effects of ATGL-dependent lipolysis was studied in vitro in endothelial barrier integrity assay and in vivo in relation to postprandial endothelial dysfunction. The formation of LDs was invariably associated with elevated production of endogenous AA-derived prostacyclin (PGI2). In the presence of the inhibitor of ATGL or the inhibitor of cytosolic phospholipase A2,, production of eicosanoids was reduced, with concomitant increase in the number of LDs. OA administration impaired endothelial barrier integrity in vitro that was further impaired if OA was given together with atglistatin. In vivo, olive oil induced postprandial endothelial dysfunction that was significantly deteriorated by ATGL inhibition. In summary, vascular lipid droplets formation was associated with ATGL- and cPLA2-dependent PGI2 production from endogenous AA. The inhibition of ATGL resulted in an impairment of endothelial barrier function in vitro and deterioration of endothelial function upon exposure to olive oil in vivo. These results demonstrate that vascular ATGL-cPLA2-PGI2−dependent pathway activated by lipid overload and linked to LDs formation in endothelium and smooth muscle cells has a vasoprotective role and counterbalances detrimental vascular effects of lipid overload.
Predictive value of maternal serum placental growth factor levels for discordant fetal growth in twins: A retrospective cohort study
Authors: Li Shuai , Wu Kaiqi , Zhou Shaomin , Yin Binbin , Bai Xiaoxia , Zhu Bo 
Published: August 2023

Abstract
Background
Accurate prenatal recognition of discordant fetal growth in twins is critical for deciding suitable management strategies. We explored the predictive value of the level of maternal second-trimester placental growth factor (PLGF) as a novel indicator of discordant fetal growth.
Methods
A total of 860 women pregnant with twins were enrolled, including 168 women with monochorionic twins (31 cases of discordant fetal growth and 137 without) and 692 with dichorionic twins (79 cases of discordant fetal growth and 613 without). Maternal second-trimester PLGF concentrations were measured via immunofluorescence.
Results
Maternal second-trimester PLGF levels were significantly lower in women pregnant with twins who subsequently developed discordant fetal growth than in those who did not (monochorionic twin pregnancy: P < 0.001; dichorionic twin pregnancy: P < 0.001). A 3–4 fold difference in median PLGF concentrations was detected between the two groups with both monochorionic and dichorionic twin pregnancies. Maternal second-trimester PLGF levels were significantly correlated with birth weight differences (monochorionic twin pregnancy: r = − 0.331, P < 0.001; dichorionic twin pregnancy: r = − 0.234, P < 0.001). A receiver operating characteristic curve was used to evaluate the predictive efficiency. In monochorionic twin pregnancies, the area under the curve (AUC) was 0.751 (95% confidence interval [CI]: 0.649–0.852), and the cutoff value was 187.5 pg/mL with a sensitivity of 77.4% and specificity of 71.0%. In dichorionic twin pregnancies, the AUC was 0.716 (95% CI; 0.655–0.777), and the cutoff value was 252.5 pg/mL with a sensitivity of 65.1% and specificity of 69.6%. Based on the above cutoff values, univariate and multivariate logistic regression analyses were performed to calculate the odds ratios (OR) for the PLGF levels. After adjustment for potential confounding factors, low PLGF concentrations still significantly increased the risk of discordant fetal growth (monochorionic twin pregnancy: adjusted OR: 7.039, 95% CI: 2.798–17.710, P < 0.001; dichorionic twin pregnancy: adjusted OR: 4.279, 95% CI: 2.572–7.120, P < 0.001).
Conclusions
A low maternal second-trimester PLGF level is considered a remarkable risk factor and potential predictor of discordant fetal growth. This finding provides a complementary screening strategy for the prediction of discordant fetal growth and offers a unique perspective for the subsequent research in this field.
An Optimized Edward-elgamal Extreme Performance Signature Scheme Oedecas in Iot and Blockchain
Authors: R Anusha , Saravanan R. 
Published: August 2023

Abstract
Digital signatures (DS) are the modern-day guardians of authenticity and security in the digital realm. Even though the goal has stayed the same, the scope of its suitability and the boundaries at which it can be applied have necessitated perpetual improvements in speed, safety, and computation. Increased DS secure efficiency is in high demand, especially considering the Internet of Things (IoT), blockchain technology (BC), and cryptocurrencies. Signatures are generated using a digital signature scheme (DSS). To address the nonrepudiation problem of IoT over the Blockchain ecosystem, let us create this scheme. This article explores EdDSA (Edward Curve Digital Signature Algorithm), a popular DSA, along with a proposed hybrid signature, and how it can be implemented in the IoT based on BC. It also compares the Edward, Hyperelliptic, and Elliptic curve cryptography. Then, we compared the Edwards curve digital signature algorithm (EdDSA) to Elliptic Curve DSA(EcDSA) heuristically and Hyper Elliptic Curve DSA(HeDSA). The study results demonstrate that EdDSA is an improvement over ECDSA and HeDSA. From the study, the proposed scheme, Optimized Edward-El Gamal with Extreme performance Edward curve Accumulate signature (OEDECAS), provides more security and is evaluated to be used in the Blockchain and IoT sectors with positive results right away. It shows a 15% improvement in the transaction flow, a 15% improvement in block validation, and tamper-proof security for IoT, like the same system, implemented without OEDECAS.
Antegrade versus retrograde approach for recanalization of ostial or stumpless coronary chronic total occlusion
Authors: Wu Xi , Wu Ming-Xing , Huang Hao-Bo , Liu Zhe , Cai Jie , Zhang Qi-Zhou , Huang He 
Published: August 2023

Abstract
Background Data on the procedural and in-hospital clinical effects of the antegrade-only and retrograde methods for ostial or stumpless CTO PCI are scarce.The purpose of this research was to assess the procedural and in-hospital clinical results of percutaneous coronary intervention (PCI) for ostial or stumpless chronic total occlusion (CTO) using both the antegrade-only and retrograde approaches.Methods We performed a retrospective analysis of the procedural and in-hospital clinical effect of 89 consecutive patients who received ostial or stumpless CTO PCI at our institution between April 2015 and October 2022.Results The antegrade-olny method had a higher technical success rate(92.0% vs.71.9%,p = 0.041 ) and procedural success rate(92.0% vs.68.8%,p = 0.022 ) compared to the retrograde approach (RA) .The RA group had a substantially greater Japanese-CTO (J-CTO) score than the antegrade only approach group (2.45 ± 0.73 vs. 1.64 ± 0.70, p < 0.001). Lesion length of 20 mm or more was notably more prevalent in the RA group than the antegrade-only group (73.4% vs. 28.0%, p < 0.001). The antegrade-only approach group exhibited a higher incidence of microchannels at the proximal stump compared to the RA group (56.0% vs. 10.9%, p < 0.001). In-hospital major adverse cardiac events (MACE) and in-hospital myocardial infarction (MI) were more frequently observed in the RA cases (18.8% vs. 0, p = 0.003; 15.6% vs. 0, p = 0.008). The J-CTO score of less than 2 and the presence of microchannels at the proximal stump were identified as predictors for successful antegrade-only approach PCI for ostial or stumpless CTO (OR: 2.79 [95% CI: 1.92–5.03, P = 0.003]; OR: 2.89 [95% CI: 1.32–6.03, P = 0.001]).Conclusions Compared to RA PCI for ostial or stumpless CTO, the antegrade only approach is utilized for less complex CTO lesions and omes with a reduced likelihood of in-hospital MACE and complications.