bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Evaluation of Sulfobutylether-β-cyclodextrin Inclusion
Complexes of Etoricoxib for Enhancing Dissolution
Authors: Vishvakarma Vivekanand , Kaur Malkiet , Nagpal Manju , Maman Paramjot 
Published: June 2023

Introduction:
Etoricoxib is a BCS class II drug with poor aqueous solubility and analgesic
and anti-inflammatory properties. Complexation with cyclodextrins is one of the widely used
methods, amongst others, for enhancing the solubility and bioavailability of drugs. In current research
work, inclusion complexes of etoricoxib using modified forms of cyclodextrin, i.e., captisol
were prepared using kneading, evaporation, and freeze-drying methods to improve the solubility
and dissolution characteristics.

Methods:
Etoricoxib inclusion complexes (ratio 1:1) were formulated using kneading, evaporation,
and freeze-drying methods. The formulated inclusion complexes were evaluated for phase solubility,
equilibrium solubility studies, Fourier transform infrared spectroscopy, powder X-ray diffraction,
scanning electron microscopy, differential scanning calorimetry studies, in vitro drug release,
similarity factor and in vivo studies.

Results:
The freeze-drying method produced inclusion complexes with the highest equilibrium solubility
(ten times that of the pure drug). Fourier transform infrared spectroscopy studies showed no
drug-polymer interaction. Differential scanning calorimetry and scanning electron microscopy studies
suggested the incorporation of the drug into inclusion complexes of cyclodextrin. In vitro dissolution
studies of kneading, evaporation and freeze-drying method inclusion complexes showed
66.53%, 79.13% and 88% drug release, respectively, in 3h, whereas pure drug exhibited 61.77%
drug release in 3 h. The f1 value obtained was less than 50, which is indicative of a significant difference
in release characteristics of kneading, evaporation and freeze-drying methods with that of
the marketed formulation. In vivo studies indicated that inclusion complexes formulated by the
freeze-drying method showed better analgesic and anti-inflammatory effects in comparison to formulations
prepared by kneading and evaporation methods.

Conclusion:
It is concluded that the formulation prepared by the freeze-drying method led to a significant
enhancement of dissolution and solubility rate of etoricoxib in comparison to the formulation
prepared by the kneading method and evaporation method.
Early Marriage and its Association with the Socioeconomic and Sociocultural Factors of Women in Sudan: A Predictive Model
Authors: Abdallah Ahmed Saied Rahama , Mohammed Mohammed Omar Musa , Mohamed Adel Ali Ahmed 
Published: June 2023

Background:
Early marriage is spreading in Sudan, like in most African countries. Early marriage is defined as any marriage that happens before the age of 18. Early marriage is a human rights violation and has a huge negative effect, especially on girls.

Objectives:
The aim of this study was to assess the prevalence and determinants of socioeconomic and sociocultural factors associated with women's early marriage in Gezira state in Sudan.

Methods:
The study depended on primary data from Gezira state (2021). The study adopted the questionnaire as a tool for data collection. The questionnaire was designed to collect data on variables related the early marriage. The descriptive statistics, chi-square test, and logistic regression model were used to analyze the collected data.

Results:
The results revealed that the prevalence of early marriage among females in Gezira state was 54.9%, the prevalence of early marriage among rural areas was 57.3%, and there was a significant association between early marriage and unemployment. The result of the logistic regression model showed that there was a significant relationship between early marriage and the factors such as area, wealth index quantile, unemployment, and exposure to media. Whereas the model found an insignificant association between early marriage and the factors such as low financial condition leading to early marriage, early marriage is one of the signs of urbanization, immigrant cultures support early marriage, establishing a good maternal relationship between the child and the mother.

Conclusion:
Early marriage is widespread in Gezira state, and it is associated with socioeconomic and sociocultural factors.
The Difference in Mouthwash Side Effects of Persica and Chlorhexidine for Preventing Ventilator-induced Pneumonia among Patients Admitted to the Intensive Care Unit
Authors: Kiabi Farshad Hassanzadeh , Baradari Afshin Gholipour , Kiasari Alieh Zamani , Shahheidari Mahdi 
Published: June 2023

Background:
Pneumonia is a common cause of morbidity and mortality in ICU patients under mechanical ventilation. In recent years the use of herbal mouthwashes, due to antimicrobial effects and fewer side effects, has been studied in reducing the incidence of ventilator-associated pneumonia (VAP). In this study, the effect of Persica mouthwash in the prevention of VAP in ICU patients was compared with chlorhexidine.

Methods:
This study is a double-blind, randomized clinical trial among ICU patients under mechanical ventilation. Fifty patients were divided into two groups, the control group used 10 ml Chlorhexidine 2.0%, and the intervention group used 10cc Persica as a mouthwash. The incidence of pneumonia, mortality, length of hospital stays, mechanical ventilation duration, CPIS (Clinical Pulmonary Infection Score), and SOFA (sequential organ failure assessment) score and complications were evaluated among the two groups.

Results:
The incidence of pneumonia, mortality, SOFA score, and CPIS in the two groups were not significantly different. Length of stay in the ICU and mechanical ventilation duration were also not significantly different in the two groups, p>0.05. Side effects with chlorhexidine were significantly more often than Persica (44% vs. 8%) p=0.008.

Conclusion:
The incidence of early pneumonia in patients with no baseline pneumonia did not differ with Persica and Chlorhexidine mouthwash. At the same time, the incidence of side effects caused by the use of Persica was significantly less.

Clinical Trial Registrations No.:
RCT2017022032676N1.
Kalanchoe pinnata (Patharchatta): A Therapeutic Boon to Mankind
Authors: Wadhwa Sapna , Boora Sanjit , Soniya Kumari , Yadav Suman , Kaushik Sulochana , Kumar Ramesh , Kaushik Samander 
Published: June 2023

Abstract:
Bryophyllum pinnatum, commonly known as the “patharchatta,” belongs to the family of “Crassulaceae.” Bryophyllum pinnatum is often used to treat gallbladder stones and heal wounds. It possesses a lot of pharmacological properties, such as antioxidant, anti-cancerous, antimicrobial, antiviral, etc. It is an aromatic plant having a sweet and sour smell and is used as a herb. In different plant species, essential oils present in the leaves and other parts give them their unique smell and fragrance. Many phytochemicals have been isolated from this plant, like alkaloids, triterpenes, cardenolides, flavonoids, and bufadienolides, as well as lipids, steroids, and glycosides from vari-ous extracts. Among them, only some compounds have medicinal properties. In this review, we have analyzed the ADME properties of the phytochemicals present in the plant to identify which chemical can act as a drug candidate using the SwissADME server.
Trends of Software Development Methodologies Toward DevOps:
Analysis and Review
Authors: Narang Poonam , Mittal Pooja 
Published: June 2023

Background:
The trend of software development has always been challenging for industry
experts and software developers. There is tremendous growth in software development
methodologies under the influence of evolving technologies and the rising demands of society.
The 2019 pandemic forced software developers to shut down their offices and begin working
from home, thereby, highlighting the critical necessity for a shared development and operations
teams platform. As a result, the development trend moves from waterfall and Agile towards
DevOps.

Objective:
The objective of the research is to review and comparatively analyze the availability
factor of different selective and required features in software development methodologies. Software
development industries will be benefited in appropriate methodology selection based on the
requirement.

Methods:
The analysis is based on review of different development methodologies based on existing
literature study, Google, and Stack Overflow Trends followed by tabular comparison of
Waterfall, Iterative, Prototype, Spiral development models under Traditional and Rapid Application
Development (RAD), Scrum, Kanban, XP for Agile methods with DevOps automation culture
on essential features.

Results:
The moving trend towards DevOps, from Traditional and Agile development, demonstrate
the most recent market swings for these models. Although Traditional models adhere to
outdated software development methodologies, they are included in this high-quality survey and
evaluation because of their widespread use in the software industry and prominent researcher’s
survey work.

Conclusion:
Software developers, students, and researchers will all find it simple to comprehend
the workings of development processes as a result of this analytical review. Additionally, it will
also make it easier for these target audiences to choose relevant and effective models for software
development.
Perancangan wayang Isekai sebagai alternatif pentas wayang untuk generasi muda
Authors: Arif Novida Nur Miftakhul 
Published: June 2023

Merespon masalah mental yang kerap dialami oleh generasi muda melalui media pendidikan karakter yang memanfaatkan pentas wayang merupakan tujuan utama riset dan perancangan karya Wayang Isekai. Masalah mental dan menghilangnya pentas wayang selama pandemi Covid-19 merupakan persoalan aktual yang perlu direspon secara kreatif seperti dengan wayang kontemporer. Metode produksi film atau multimedia digunakan dalam eksperimen ini, yaitu pra produksi, produksi dan paska produksi. Di dalamnya juga melibatkan observasi, wawancara, studi pustaka, eksplorasi dan inovasi. Hasil dari riset dan perancangan media ini adalah Wayang Isekai, eksperimen pentas daring yang memadukan pentas wayang, animasi dan live action dengan cerita yang merepresentasikan perjalanan batin menuju self-awarenes. Wayang Isekai mampu menjadi alternatif media penyampai pesan kebaikan seperti pendidikan karakter. Kata Kunci: wayang, kontemporer, generasi muda, masalah mental THE DEVELOPMENT OF WAYANG ISEKAI AS ALTERNATIVE WAYANG PERFORMANCE FOR YOUNG GENERATION Abstract Responding the mental issues that are often experienced by the young generation through the medium of character education that utilizes wayang performance is the main goal of the research and development of Wayang Isekai. A contemporary wayang is a creative way to respons mental issues and the disappearance of puppet performances during the Covid-19 pandemic. Film or multimedia production method was used in this experiment, namely pre-production, production and post-production. It also involved observation, interviews, literature studies, exploration, and innovation. The result of this research is Wayang Isekai, an online performance that combined puppetry, animation and live action with stories that represent the inner journey towards self-awareness. Wayang Isekai is able to become an alternative medium for conveying positive messages such as character education. Keywords: wayang, contemporer, young generation, mental issue
Eklektik filosofis, teknis, dan psikologis bermain biola dalam pengembangan pembelajaran musik di Indonesia
Authors: Fu'adi Fu'adi , Walidaini Birul , Agustianto Agustianto , Sritanto Sritanto 
Published: June 2023

In learning the violin, there are various kinds of challenges and obstacles, both technical and non-technical. Strong motivation is needed, supported by appropriate learning methods so that students can develop into capable violinists. This article outlines the philosophical, technical, and psychological aspects of violin learning by world-class violin pedagogues, which are then analyzed in an eclectic manner in order to obtain new approaches that can be applied to develop violin learning in Indonesia. The literature review method is used to select important aspects used in violin learning. The research results show important points of philosophical study in learning the violin include philosophy in starting to learn the violin, mental approach, emotional aesthetics, and talent in music. Technical and psychological studies include body position in playing the violin, sound production, intonation, vibrato, legato, musical nuances, psychological musicians, and the repertoire played. It can be interpreted that these selected and analyzed philosophical, technical, and psychological values of how to play the violin can become the basis for understanding and efforts to build students' capabilities in playing the violin in a comprehensive manner, in accordance with the Indonesian cultural background. Keywords: Eclectic, philosophy, violin technique, musical learning
Faktor yang Berhubungan dengan Minat Masyarakat dalam Memanfaatkan Layanan PUSTAKA (Puskesmas Tanpa Antrean Kota Semarang)
Authors: Khoerunnisak Khoerunnisak , Arso Septo Pawelas , Kusumastuti Wulan 
Published: June 2023

Latar Belakang: Puskesmas Krobokan Semarang mempunyai antrean rawat jalan yang cukup banyak di tempat pendaftaran. Dalam mengatasinya, Puskesmas Krobokan menerapkan layanan Puskesmas Tanpa Antrean Kota Semarang (PUSTAKA) yang telah dikembangkan oleh Dinas Kesehatan Kota Semarang. Namun, dalam pelaksanaannya layanan ini belum dimanfaatkan secara optimal oleh masyarakat.Tujuan: Mengetahui hubungan antara kondisi fasilitasi, motivasi hedonis, nilai harga dan kebiasaan dengan minat masyarakat dalam memanfaatkan PUSTAKA.Metode: Penelitian kuantitatif ini menggunakan desain cross sectional. Teknik pengambilan sampel adalah accidental sampling dengan menggunakan kuesioner sebagai instrumen penelitian. Dalam penelitian ini dilakukan analisis univariat dan analisis bivariat dengan menggunakan uji chi-square. Pengumpulan data dilakukan secara kualitatif untuk menggali informasi lebih dalam terhadap responden.Hasil: Sebanyak 71,3% responden berminat dalam memanfaatkan layanan PUSTAKA. Terdapat hubungan antara kondisi fasilitasi, motivasi hedonis, nilai harga dan kebiasaan dengan minat masyarakat dalam memanfaatkan layanan PUSTAKA dengan p-value ≤ 0,05.Kesimpulan: Sebagian besar responden berminat menggunakan layanan PUSTAKA di Puskesmas Krobokan.
La recepción del debate sobre reconstrucciones racionales/reconstrucciones contextuales en 1988 y la historiografía filosófica mexicana
Authors: Rodríguez Teresa 
Published: June 2023

En este artículo analizo la recepción del artículo de Rorty “The historiography of philosophy, four genres” en el seno del número 34 de Diánoia. Revista de Filosofía, publicado en 1988. Pretendo mostrar cómo, a partir de tal artículo, los y las autoras de los textos propusieron nuevas tesis que sirven como antecedentes de dos modelos ampliamente difundidos en México: el modelo de las vías de reflexión y el modelo de la hermenéutica analógica. Con ello, el texto busca profundizar en el estudio y la comprensión de la historiografía de la filosofía en México durante la segunda mitad del siglo XX.
PENGARUH GRIT TERHADAP KEPUASAN KERJA DIMEDIASI OLEH WORK-LIFE BALANCE PADA ASN
Authors: Ghina Yaniar Syafitri  
Published: June 2023

Kepuasan kerja merupakan perasaan positif pada suatu pekerjaan, yang merupakan dampak atau hasil evaluasi dari berbagai aspek pekerjaan tersebut. Grit merupakan salah satu faktor yang dapat mempengaruhi kepuasan kerja. Individu dengan grit yang tinggi akan mencapai kepuasan kerja. Grit dapat meningkatkan work-life balance, WLB yang baik akan memperoleh kepuasan kerja yang tinggi. Tujuan dari penelitian ini adalah untuk membuktikan pengaruh grit terhadap kepuasan kerja yang terjadi baik secara langsung maupun tidak langsung dengan dimediasi oleh work-life balance. Subjek adalah ASN di Aceh dengan usia 20 – 60 tahun dan lama kerja minimal 2 tahun. Data diukur menggunakan skala kepuasan kerja, Grit scale (Grit-s), Work-Life Balance Scale. Analisis mediasi dilakukan melalui Process Model 4 dari Hayes. Hasil penelitian menunjukkan bahwa pengaruh grit terhadap kepuasan kerja terjadi secara langsung (β = 0.636; p <0.001), maupun tidak langsung dengan dimediasi oleh work-life balance (β = 0.246, LLCI = 0.064, ULCI = 0.124). Selanjutnya, terdapat pengaruh positif yang signifikan antara grit dengan work-life balance (β = 0.685; p < 0.001) dan Work-life balance mempengaruhi kepuasan kerja (β = 0.359; < 0.001).
Pengaruh Kecanduan Internet Dan Future Time Perspective Terhadap Prokrastinasi Akademik Dikalangan Pelajar
Authors: Afifah Asyifak Nurul 
Published: June 2023

Prokrastinasi akademik merupakan perilaku menunda-nunda mengerjakan atau menyelesaikan tugas-tugas akademik. Prokrastinasi akademik di kalangan pelajar dapat mengakibatkan kegagalan akademik, tidak naik kelas bahkan putus sekolah. Tujuan dalam melakukan penelitian ini adalah untuk mengetahui pengaruh kecanduan internet dan future time perspective terhadap prokrastinasi akademik di kalangan pelajar. Penelitian ini merupakan penelitian kuantitatif dengan subjek penelitian siswa SMP. Alat ukur yang digunakan adalah Young Internet Addiction Diagnostic Questionnaire, Tuckman Procrastination Scale dan Future Time Perspective for Adolescent and Young Adults. Analisis data menggunakan analisis regresi linier berganda. Dari penelitian ini diperoleh koefisien determinasi (R²) sebesar 0,426 dan F Sig. 0,000<0,050. Dari hasil uji t didapatkan hasil ada pengaruh positif yang signifikan antara kecanduan internet dengan prokrastinasi akademik dengan nilai t=5,641 dan ada pengaruh negatif yang signifikan antara future time perspective dengan prokrastinasi akademik dengan nilai t = -11,543. Nilai beta dalam harga mutlak untuk kecanduan internet adalah 0,262 dan nilai beta untuk future time perspective adalah 0,536 sehingga dapat disimpulkan future time perspective lebih berpengaruh terhadap prokrastinasi akademik.
Tafsīr Al-Aḥkām's Analysis of Demoralization in Cases of Sexual Harassment in Educational Institutions in Indonesia
Authors: Sangaji Ruslan , Amin Surahman , Muhammadun Muzdalifah , Syarifuddin Samsinar , Usman Bustami 
Published: June 2023

Sexual harassment is a violation of Islamic law and is inconsistent with the values of all religions and moral norms. The rise of sexual violence in educational institutions is concerning. This study aims to analyze and evaluate the demoralization that occurs in Indonesian educational institutions after the emergence of sexual harassment committed by caregivers or staff. Using a descriptive qualitative method analyzed through the tafsīr al-aḥkām approach, data was collected through interviews and literature studies. The findings indicate that sexual harassment in educational institutions is often done through coercion, using dogmatic methods or luring victims. This behavior undermines the maqāshid of the Qur'an, teachings of all religions, and moral norms. Teachers and caregivers are meant to be dignified and honorable people. Sexual harassment is a form of sexual violence that harms victims both physically and mentally. Interpretation scholars emphasize that every individual has the right to dignity and honor, which Islamic shari'a regulates. Therefore, Islamic law prohibits immoral acts, including sexual harassment, which is considered faḥsyā’ or fāḥisyah (abominable), as it can injure human glory and dignity. The demoralization that occurs will affect the degradation of the charisma of educational institutions and weaken the sacred relationship between caregivers and students.
Legal Study of Building Sharia-based Investment in Aceh: The Challenges After the Enactment of the Qanun of Sharia Financial Institution
Authors: Yahya Azhari , Yusri Yusri , Adwani Adwani , Adli M. , Jafar M. 
Published: June 2023

The presence of Aceh Qanun Number 11 of 2018 concerning Sharia Financial Institution (SFI) is an important breakthrough in building a Sharia-based economy in Aceh. This goes hand in hand with Aceh's privileges in implementing Islamic law as stipulated in the Aceh Qanun Number 8 of 2014 concerning Principles of Islamic Sharia. Hence, this research aims to scrutinize the challenges in building Sharia-based investments in Aceh after the enactment of the Qanun of SFI. This study was conducted using normative legal methods with statutory and Sharia economic law approaches. The data analyzed are literature and legal rules such as laws, qanuns, books, and articles related to the discussion. The results of this study indicate that there are several challenges occur in building Sharia-based investments in Aceh. Firstly, lack of understanding about SFI Qanun by stakeholders because not all of them have a full understanding of the contents of this Qanun. Secondly, limited access to financial resources that can be used by investors, and business actors to run their businesses. Thirdly, Aceh's low economic growth has resulted in low investors interested to invest in Aceh. This condition has a significant impact on the sustainability of Sharia-based investments in Aceh. Fourthly, inadequate infrastructure especially information technology infrastructure to support the implementation of the Qanun of SFI. Therefore, it is suggested to the Government of Aceh provide a better understanding of the Qanun of SFI at all levels of society. Then, the government also needs to open access to financial resources for the investors and business actors who want to invest in Aceh. Besides, appropriate measures to increase economic growth in Aceh need to be taken promptly so that incoming investment may increase gradually. Finally, in the context of the Sharia economy, the existence of the LSK qanun is part of legal efforts for the benefit of all financial transactions in Aceh in accordance with Islamic Sharia values.
The Impact of Changes in Pension Accounting under IAS 19R on Shareholder Wealth
Authors: Chiu Tzu-Ting , Ogudugu David 
Published: June 2023

ABSTRACT
This study examines stock price reactions to International Accounting Standards Board announcements associated with International Accounting Standard (IAS) 19R during the standard-setting process. IAS 19R removes the corridor approach in accounting for actuarial gains and losses on defined benefit plans. This rule change likely weakens the financial position of most firms that previously used the corridor approach upon adoption and subsequently increases balance sheet volatility. Using a sample of listed firms in Norway, we find that the market generally reacts negatively to IAS 19R events, but stock price responses are insignificantly different for affected and unaffected firms, suggesting that shareholders view the standard as value neutral. However, market reactions are more negative for firms with higher bankruptcy risk. Additional analyses indicate that market reactions vary with discretion in actuarial assumptions and funded status. Overall, our results document how investors respond to the amendments to pension accounting rules under IAS 19R.