Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units
Authors: Yan Kai , Cheng Guoqiang , Zhou Wei , Xiao Feifan , Zhang Chongfan , Wang Laishuan , Zhang Peng , Lu Chunmei , Kong Yanting , Wang Xinhua , Zhou Yuanfeng , Lu Weineng , Tang Juan , Song Xiaoyan , Wei Qiufen , Meng Danhua , Yao Liping , Zhuang Deyi , Qu Liuhong , Xu Qinghuo , Yin Zhaoqing , Su Le , Wan Jing , Si Yuan , Fujioka Kazumichi , Mussap Michele , Kanungo Shibani , Bhandari Vineet , Huang Weimin , Pan Xinnian , Zhou Wenhao ,   China Neonatal Neuro-Critical Care Network group, Shi Yuan , Yang Changyi , Zhu Huaping , Hei Mingyan , Feng Xing , Ding Xin , Lin Zhenlang , Chen Shangqin , Du Lizhong 
Published: July 2023

ImportanceNeonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal seizures and monitoring systems in China are lacking.ObjectivesTo determine the incidence of neonatal seizures in infants with high risk in China.Design, Setting, and ParticipantsA large, cross-sectional multicenter study was conducted from January 2017 to December 2018 in the neonatal intensive care units (NICUs) of 7 tertiary medical centers in China. Neonates with high risk were included, and cEEG monitoring was conducted. Data were collected between January 1, 2017, and January 31, 2020. The data were analyzed between January 2021 and January 2022.Main Outcomes and MeasuresThe incidence of neonatal seizures, categorized by etiology, and seizure burden.ResultsA total of 20 310 neonates with high risk were included (10 495 [51.7%] male; mean [SD] postmenstrual age, 37.7 [3.7] weeks), and seizures were observed in 3423 infants (16.9%). The highest proportion of seizures was attributed to acute neonatal encephalopathy (1448 [42.3%]). The incidence of seizures decreased with postmenstrual age and birth weight, with the highest occurrence observed in neonates with postmenstrual age of less than 28 weeks (237 of 879 [27.0%]) or birth weight of less than 1.0 kg (269 of 914 [29.4%]). Preterm infants had a higher proportion of moderate and severe seizure burdens compared with full-term infants (moderate severity: 248 of 1199 [20.7%] vs 454 of 2224 [20.4%]), but no significant differences were observed in etiology. Seizure burden was highest with genetic syndromes (49 of 188 [26.1%]), central nervous system malformations (33 of 127 [26.0%]), and inborn errors of metabolism (27 of 113 [23.9%]). During hospitalization, 7.8% of neonates with seizures died (267 neonates), with 81.3% of these cases having a moderate or severe seizure burden (217 neonates). Mortality was generally higher in preterm vs full-term infants (98 of 1199 [8.2%] vs 169 of 2224 [7.6%]) and increased with the severity of seizure burden (217 of 267 neonates with moderate or severe burden [81.3%]).Conclusions and RelevanceThis cross-sectional study of neonatal seizures underscores the substantial burden seizures pose to high-risk infants with brain injury in China, particularly those who are born prematurely or who have congenital conditions.