bluuebunny/crossref_metadata_2025_split huggingface dataset:
International cooperation, production side emissions and environmental sustainability
Authors: Gani Azmat 
Published: January 2023

PurposeRising greenhouse gases have contributed to global warming above the pre-industrial levels with detrimental effects on world climatic patterns. Extreme weather has inflicted drastic impacts, including loss of lives and livelihoods and economic disruption. However, collective international cooperation in adopting greenhouse gas emission mitigating measures can translate into long-run beneficial effects of improving environmental quality. This study examines if international environmental cooperation among the world's top ten polluters can reduce production side emissions.Design/methodology/approachThe panel estimation procedure was applied to data from ten top polluting countries from 2000 to 2019.FindingsThe results revealed a statistically significant inverse association between a nation's commitments to international environmental treaties and carbon dioxide emissions. Other than confirming the environmental Kuznets curve effect, industrial intensification, international trade and law rule are other strong correlations of carbon dioxide emissions.Research limitations/implicationsThe main policy implication is the urgency for the leaders of the world's top ten polluters to actively cooperate in developing and implementing new production-side carbon emission measures as well as the implementation and enforcement of existing international treaties to minimize further environmental damage and let the countries in the lower ranks of carbon emissions to enjoy the long-run benefits of the decarbonized world.Originality/valueThis study makes a new contribution to the environmental research literature by unfolding how collective global cooperation on environmental challenges can help reduce environmental damage in a coherent analytical framework.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/IJSE-09-2022-0598
Decisions of pricing and delivery-lead-time in dual-channel supply chains with data-driven marketing using internal financing and contract coordination
Authors: Xu Senyu , Tang Huajun , Huang Yuxin 
Published: January 2023

PurposeThe purpose of this research is to investigate how to introduce a financing scheme to tackle the manufacturer's capital constraint problem, discuss the effects of data-driven marketing (DDM) quality, cross-channel-return (CCR) rate and financing interest rate on the members' pricing and delivery-lead-time decisions and optimal performances, and analyzes `how to achieve the coordination within a dual-channel supply chain (DSC) by contract coordination.Design/methodology/approachThis work establishes a DSC model with DDM, and the offline retailer can provide internal financing to the capital-constrained online manufacturer. The demand under the price is determined based on DDM quality, customer channel preference and delivery lead time. Then, combined with the Stackelberg game, the optimal pricing and delivery-lead-time decisions are discussed under the inconsistent and consistent pricing strategies with decentralized and centralized systems. Furthermore, it designs a manufacturer-revenue sharing contract to coordinate the members under the two pricing strategies.Findings(1) The increase of DDM quality will reduce the delivery-lead-time under the inconsistent or consistent pricing strategy and will push the selling prices; (2) The growth of the CCR rate will raise selling prices and extend the delivery-lead-time under the decentralized decision; (3) Under price competition, the offline selling price is higher than the online selling price when customers prefer the offline channel and vice versa; (4) The retailer and the manufacturer can achieve a win-win situation through a manufacturer-revenue sharing contract.Originality/valueThis paper contributes to the studies related to DSC by investigating pricing and delivery-lead-time decisions based on DDM, CCR, internal financing and supply chain contract and proposes some managerial implications.
Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review
Authors: De Decker Ignace , Logé Thomas , Hoeksema Henk , Speeckaert Marijn M. , Blondeel Phillip , Monstrey Stan , Claes Karel E. Y. 
Published: January 2023

AbstractIntra‐ and transdermal administration of substances via percutaneous injection is effective but considered painful, and inconvenient in addition to bringing forth biohazardous waste material. In contrast to injection, topical drug application, which includes ointments, creams and lotions, increases the local drug load. Moreover, it has reduced side effects compared to systemic administration. However, the epidermis poses a barrier to high molecular weight substances, limiting the delivery efficiency. Dissolving microneedles (DMN) are hydrophilic, mostly polymer‐based constructs that are capable of skin penetration and were developed to provide painless and direct dermal drug delivery. This systematic review provides a comprehensive overview of the available clinical evidence for the use of DMN to treat various skin conditions. According to the PRISMA statement, a systematic search for articles on the use of DMN for dermatological indications was conducted on three different databases (Pubmed, Embase, and the Cochrane library). Only human clinical trials were considered. Qualitative assessment was done by two separate reviewers using the Cochrane risk of bias (RoB 2) and Chambers' criteria assessment tools. The search yielded 1090 articles. After deduplication and removal of ineligible records, 889 records were screened on title and abstract. Full text screening was done for 18 articles and ultimately 17 articles were included of which 15 were randomized controlled trials and two were case series. The quality assessment showed that the majority of included studies had low to no risk of bias. Clinical data supports that DMN are an excellent, effective, and pain free drug delivery method for multiple dermatological disorders including skin aging, hyperpigmentation, psoriasis, warts, and keloids by supplying a painless and effective vehicle for intradermal/intralesional drug administration. Microneedle technology provides a promising non‐ to minimally‐invasive alternative to percutaneous injection.
Plant attributes interact with fungal pathogens and nitrogen addition to drive soil enzymatic activities and their temporal variation
Authors: Nwe Thu Zar , Maaroufi Nadia I. , Allan Eric , Soliveres Santiago , Kempel Anne 
Published: January 2023

Abstract

Nitrogen enrichment can alter soil communities and their functioning directly, via changes in nutrient availability and stoichiometry, or indirectly, by changing plant communities or the abundance of consumers. However, most studies have only focused on one of these potential drivers and we know little about the relative importance of the different mechanisms (changes in nutrient availability, in plant diversity or functional composition or in consumer abundance) by which nitrogen enrichment affects soil functioning. In addition, soil functions could vary dramatically between seasons; however, they are typically measured only once during the peak growing season. We therefore know little about the drivers of intra‐annual stability in soil functioning.

In this study, we measured activities of β‐glucosidase and acid phosphatase, two extracellular enzymes that indicate soil functioning. We did so in a large grassland experiment which tested the effects, and relative importance, of nitrogen enrichment, plant functional composition and diversity, and foliar pathogen presence (controlled by fungicide) on soil functioning. We measured the activity of the two enzymes across seasons and years to assess the stability and temporal dynamics of soil functioning.

Overall β‐glucosidase activity was slightly increased by nitrogen enrichment over time but did not respond to the other experimental treatments. Conversely, plant functional diversity and interactions between plant attributes and fungicide application were important drivers of mean acid phosphatase activity. The temporal stability of both soil enzymes was differently affected by two facets of plant diversity: species richness increased temporal stability and functional diversity decreased it; however, these effects were dampened when nitrogen and fungicide were added.

The fungicide effects on soil enzyme activities suggest that foliar pathogens can also affect below‐ground processes and the interacting effect of fungicide and plant diversity suggests that these plant enemies can modulate the relationship between plant diversity and ecosystem functioning. The contrasting effects of our treatments on the mean versus stability of soil enzyme activities clearly show the need to consider temporal dynamics in below‐ground processes, to better understand the responses of soil microbes to environmental changes such as nutrient enrichment.

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STRETCH: Stinging tree exposures to Cairns Hospital
Authors: Young Ruth , Jackson Angela , Ryan Fiona , Little Mark 
Published: January 2023

AbstractObjectivesTo evaluate the burden of disease, investigate the treatment and response to treatment caused by exposure to stinging tree plants presenting to Cairns Hospital over a 3‐year period. Our secondary aim was to examine the benefit from treating such exposures with topical dilute hydrochloric acid (HCl).MethodsA retrospective chart review of all patients presenting to Cairns ED over a 3‐year period because of stinging tree exposure. Symptoms, signs, treatment and outcomes were recorded.ResultsThere were 48 presentations, all having immediate pain after contact with the stinging tree, with 87% describing the pain as moderate or severe. Nearly all were stung on limbs (96%). There were 13 different treatments prior to presentation. In hospital, 60% needed opioid analgesia and a median oral morphine dose equivalent of 15 mg. Of the 29 receiving HCl nine patients reported good relief or complete relief.ConclusionsStinging tree exposure results in significant presentations to the Cairns ED each year. Pain is immediate and severe and there are no clear first aid or definitive treatment recommendations. Further work is needed to ascertain the best first aid and definitive treatment including a formal trial of dilute HCl.
EndophyticPenicilliumspecies secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi
Authors: Azar Neri , Liarzi Orna , Zavitan Maor , Samara Mohamed , Nasser Ahmed , Ezra David 
Published: January 2023

AbstractThe worldwide demand for reduced and restricted use of pesticides in agriculture due to serious environmental effects, health risks and the development of pathogen resistance calls for the discovery of new bioactive compounds. In the medical field, antibiotic‐resistant microorganisms have become a major threat to man, increasing mortality. Endophytes are endosymbiotic microorganisms that inhabit plant tissues without causing any visible damage to their host. Many endophytes secrete secondary metabolites with biological activity against a broad range of pathogens, making them potential candidates for novel drugs and alternative pesticides of natural origin. We isolated endophytes from wild plants in Israel, focusing on endophytes that secrete secondary metabolites with biological activity. We isolated 302 different endophytes from 30 different wild plants; 70 of them exhibited biological activity against phytopathogens. One biologically active fungal endophyte from the genusPenicillium, isolated from a squill (Urginea maritima) leaf, was further examined. Chloroform‐based extraction of its growth medium was similarly active against phytopathogens. High‐performance liquid chromatography separation followed by gas chromatography/mass spectrometry analysis revealed a single compound—mycophenolic acid—as the main contributor to the biological activity of the organic extract.
Genome‐wide association studies demonstrate the genes associated with perimysial thickness in ducks
Authors: Tang Hehe , Liu Dapeng , Zhang Huiling , Fan Wenlei , Hu Jian , Xu Yaxi , Guo Zhanbao , Huang Wei , Hou Shuisheng , Zhou Zhengkui 
Published: January 2023

AbstractThe thickness of the perimysium has an essential effect on the tenderness of the meat. However, the genetic basis underlying perimysial thickness has not been determined. The objective of this study was to explore the quantitative trait loci (QTL) that influence perimysial thickness in an F2 segregating population generated by Mallard × Pekin duck using the genome‐wide association study (GWAS) method. Two QTL identified in chromosomes 27 and 13 displayed significant associations with perimysial thickness traits at the genome‐wide level. The strongest association was the QTL located in chromosome 27, and this region had an effect on perimysial thickness and contained a promising candidate gene MAGI3 (Membrane‐associated guanylate kinase, WW and PDZ domain containing 3). Meanwhile, association analysis showed that the top SNP within the MAGI3 gene was also associated with intramuscular fat content traits, which showed that perimysial thickness was positively correlated with intramuscular fat content. The second strongest association was the QTL region of chromosome 13. SUCLG2 (Succinate‐CoA ligase GDP‐forming subunit beta) is proximal to the top SNP and stood out as another candidate gene. Furthermore, the Transposase‐Accessible Chromatin using Sequencing result showed that some key transcription factors (MYF5, MYOD1, KLF11) related to muscle development or energy metabolism might bind to the open regions of MAGI3 and SUCLG2. By analyzing the expression of different genotypes of the candidate gene, we speculate that different genotypes of MAGI3 may have an effect on breast muscle development, and then affect the thickness of the perimysium. This study maps two major genes of the duck breast muscle perimysial thickness trait, which helps to characterize muscle development and contributes to the genetic improvement of meat yield and quality in livestock.
Functional results and feasibility of a teleprehabilitation program in patients who are candidates for elective colorectal cancer surgery during the COVID‐19 pandemic
Authors: Lorca Luz Alejandra , Ribeiro Ivana Leao , Pizarro Marta , Martínez Mónica , Vivallos Jessica 
Published: January 2023

AbstractAimTo assess the value of a prehabilitation program adapted to the current COVID‐19 pandemic using a teleprehabilitation modality in a public Latin American hospital.MethodsThe medical records of candidates for elective colorectal cancer surgery (CRC) and who completed a teleprehabiltation program were analyzed. Sociodemographic, clinical, and functional variables were analyzed, such as cardiorespiratory capacity with the sit‐to‐stand test (STST), independence in activities of daily living with the Barthel index, balance with the five‐times STST (FSTST) and fatigue with Brief Inventory Fatigue (BFI). The feasibility of the program was analyzed in terms of recruitment, retention, user satisfaction, and reporting of adverse events.ResultsOf 107 people recruited, 57 completed the program (54%, 68.78 ± 12.36 years). There was a significant difference in the BFI, FSTST, and STS 1‐min scores after the intervention (p < .01), with an effect size (Cliff's delta) that varied between −.13 and .21. There were no differences in the Barthel index score. In relation to the viability of the program, 99% of patients referred for surgery could be recruited into the program, with 53% retention. Regarding user satisfaction with the program, seven items (77.7%) were rated as “very satisfied,” and two items (22.3%) as “satisfied.” No adverse events were recorded.ConclusionThe structured prehabilitation program adapted to teleprehabilitation for CRC candidates for surgery was effective in optimizing functional results prior to surgery and was feasible to implement in a public hospital with limited resources during the COVID‐19 pandemic.
The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS‐14036/miR‐1228‐5p/PRKCDBP pathway
Authors: Jiang Rilei , Lu Bing , Feng Fanchao , Li Qian , Chen Xiaolei , Cao Shibing , Pan Zhaoxia , Deng Zhengming , Zhou Yufei , Liu Ping , Xu Jiatuo 
Published: January 2023

AbstractSeveral studies have suggested the potential value of Houttuynia cordata as a therapeutic agent in lung cancer, but direct evidence is still lacking. The study aimed to determine the regulatory impact of a major H. cordata constituent derivative (sodium new houttuyfonate [SNH]) on lncRNA networks in non‐small cell lung cancer (NSCLC) to identify new potential therapeutic targets. After exposing NSCLC cells to SNH, we analysed the following: cell death (via flow cytometry, TUNEL and ASC speck formation assays), immune factors (via ELISA), gene transcription (via RT‐qPCR), subcellular localisation (via FISH), gene–gene and gene‐protein interactions (via dual‐luciferase reporter and RNA immunoprecipitation assays, respectively) and protein expression and distribution (via western blotting and immunocytochemistry or immunohistochemistry). In addition, statistical analysis (via one‐way ANOVA or unpaired t‐tests) was performed. Exposure to SNH promoted NSCLC cell pyroptosis, concomitant with significant up‐regulation of TCONS‐14036, a novel lncRNA. Mechanistic research demonstrated that TCONS‐14036 functions as a competing endogenous (ce)RNA by sequestering microRNA (miR)‐1228‐5p, thereby up‐regulating PRKCDBP‐encoding transcript levels. Indeed, PRKCDBP promoted pyroptosis by activating the NLRP3 inflammasome, resulting in CASP1, IL‐1β and GSDMD cleavage. Our findings elucidate the potential molecular mechanisms underlying the ability of SNH to suppress NSCLC growth through activation of pyroptosis via the TCONS‐14036/miR‐1228‐5p/PRKCDBP pathway. Thus, we identify a new potential therapeutic targets for NSCLC.
Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes
Authors: Aroda Vanita R. , Erhan Umut , Jelnes Peter , Meier Juris J. , Abildlund Morten Tind , Pratley Richard , Vilsbøll Tina , Husain Mansoor 
Published: January 2023

AbstractAimGlucagon‐like peptide‐1 receptor agonists improve glycaemic control: some are now available as oral and subcutaneous formulations, and some have indications for reducing cardiovascular risk. The expanded scope for these therapies warrants comprehensive safety evaluations. We report the safety/tolerability of subcutaneous and oral semaglutide from the SUSTAIN and PIONEER clinical trial programmes, respectively.Materials and methodsAdverse events (AEs) from 16 randomized placebo‐ or active‐controlled phase IIIa trials in patients with type 2 diabetes (n = 11 159) including once‐weekly subcutaneous semaglutide (n = 3150; SUSTAIN trials) or once‐daily oral semaglutide (n = 4116; PIONEER trials) were analysed. Data pools were analysed for each programme, with separate analyses of cardiovascular outcomes trials (CVOTs; n = 6480).ResultsIn the phase IIIa pools, gastrointestinal disorders were reported in 41.9%/39.1% of patients with subcutaneous/oral semaglutide, respectively (most prevalent during initiation/escalation) versus 22.0%/24.8% with comparators. Rates of kidney disorders, acute pancreatitis, malignant neoplasms, hypoglycaemia, diabetic retinopathy, heart failure and other cardiovascular events were similar for semaglutide versus comparators. Cholelithiasis incidence was higher with subcutaneous and oral semaglutide versus placebo. Diabetic retinopathy incidence was higher with subcutaneous semaglutide versus placebo in SUSTAIN 6. Small pulse rate increases occurred with both formulations; there was no increased rate of arrhythmias. Fatal AE incidence was similar between semaglutide and comparators. Versus placebo, CVOTs showed a reduced risk of major adverse cardiovascular events with subcutaneous semaglutide and non‐inferiority criteria were met with oral semaglutide.ConclusionsThe most common AEs with semaglutide were gastrointestinal disorders, which decreased with continued therapy. These comprehensive safety/tolerability data may better inform patient selection and guidance in care.
Insider trading in multinational firms
Authors: Alldredge Dallin M. , Blank D. Brian 
Published: January 2023

AbstractWe explore insider trading at multinational firms and find multinational firm insiders make larger trades followed by larger abnormal returns relative to those at domestic firms. Multinational firm insiders profitably purchase underpriced, value stocks with low past returns. They trade more profitably, not only because of market pricing opportunities, but also because of the advantageous timing of informed trades before earnings announcements. Insider trading profits are highest at multinational firms with foreign sales in regions culturally and linguistically distinct from the United States. These findings are consistent with opportunistic insiders strategically profiting from difficult to process foreign information.
Label informed hierarchical transformers for sequential sentence classification in scientific abstracts
Authors: Tokala Yaswanth Sri Sai Santosh , Aluru Sai Saketh , Vallabhajosyula Anoop , Sanyal Debarshi Kumar , Das Partha Pratim 
Published: January 2023

AbstractSegmenting scientific abstracts into discourse categories like background, objective, method, result, and conclusion is useful in many downstream tasks like search, recommendation and summarization. This task of classifying each sentence in the abstract into one of a given set of discourse categories is called sequential sentence classification. Existing machine learning‐based approaches to this problem consider the content of only the abstract to obtain the neural representation of each sentence, which is then labelled with a discourse category. But this ignores the semantic information offered by the discourse labels themselves. In this paper, we propose LIHT, Label Informed Hierarchical Transformers – a method for sequential sentence classification that explicitly and hierarchically exploits the semantic information in the labels to learn label‐aware neural sentence representations. The hierarchical model helps to capture not only the fine‐grained interactions between the discourse labels and the words in the abstract at the sentence level but also the potential dependencies that may exist in the label sequence. Thus, LIHT generates label‐aware contextual sentence representations that are then labelled with a conditional random field. We evaluate LIHT on three publicly available datasets, namely, PUBMED‐RCT, NICTA‐PIBOSO and CSAbstract. The incremental gain in F1‐score in all the three cases over the respective state‐of‐the‐art approaches is around . Though the gains are modest, LIHT establishes a new performance benchmark for this task and is a novel technique of independent interest. We also perform an ablation study to identify the contribution of each component of LIHT in the observed performance, and a case study to visualize the roles of the different components of our model.