bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inborn errors of immunity (primary immunodeficiencies)
Authors: Kim Vy H. D. , Upton Julia E. M. , Derfalvi Beata , Hildebrand Kyla J. , McCusker Christine 
Published: January 2025

AbstractPrimary immunodeficiencies (PID), now often referred to as inborn errors of immunity (IEI), are a large heterogeneous group of disorders that result from deficiencies in immune system development and/or function. IEIs can be broadly classified as disorders of adaptive immunity (e.g., combined or humoral immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). Although the clinical manifestations of IEIs are highly variable, traditionally many disorders involve an increased susceptibility to infection. Research in recent years has underscored how IEI can present with features other than infection such as: severe atopy, autoimmunity, autoinflammation, lymphoproliferation, and/or malignancy resulting from immune dysregulation. Early consultation with a clinical immunologist is essential, as timely diagnosis and treatment are imperative for preventing significant disease-associated morbidity and mortality. The treatment of IEIs is complex and generally requires both supportive and definitive strategies, including but not limited to, immunoglobulin replacement therapy, antibiotic prophylaxis, immune response modifiers, and hematopoietic stem cell transplantation. This article provides an overview of the major categories of IEIs and strategies for the appropriate diagnosis and management of these disorders.
Immediate management of a cirrhosis-induced severe pericardial effusion: a case report and review of the literature
Authors: Taheri Maryam , Dargah Arash Hassanpour , Ramezani Pedram , Anafje Mohsen , Nasrollahizadeh Amir , Ebrahimi Pouya , Mandegar Mohammad Hossein 
Published: January 2025

Abstract
Introduction
Cardiac tamponade is a life-threatening condition resulting from fluid accumulation in the pericardial sac, leading to decreased cardiac output and shock. Various etiologies can cause cardiac tamponade, including liver cirrhosis, which may be induced by autoimmune hepatitis. Autoimmune hepatitis is a chronic inflammatory liver disease characterized by interface hepatitis, elevated transaminase levels, autoantibodies, and increased immunoglobulin G levels. This case report details a 60-year-old male with autoimmune hepatitis-induced cirrhosis presenting with severe pericardial effusion and cardiac tamponade, emphasizing the interplay between liver and cardiac pathologies.

Methods
A 60-year-old Persian man presented with progressive dyspnea, chest pain, and significant weight gain due to fluid retention. Physical examination revealed pallor, jaundice, elevated jugular venous pressure, muffled heart sounds, and tachycardia. Laboratory tests indicated severe hepatic and renal dysfunction, with elevated liver enzymes, bilirubin, and blood urea nitrogen. Imaging studies, including electrocardiogram, computed tomography angiography, and transthoracic echocardiogram, confirmed large pericardial effusion with signs of cardiac tamponade. Emergency pericardiocentesis was performed, aspirating 500 mL of serosanguinous fluid. Post-procedural management included continuous monitoring, repeat echocardiography, and a comprehensive pharmacological regimen addressing fluid overload, autoimmune hepatitis, and cardiac function.

Conclusion
This case underscores the importance of timely diagnosis and management of cardiac tamponade, particularly in patients with concomitant conditions like autoimmune hepatitis and cirrhosis. Multidisciplinary management involving hepatologists, cardiologists, and critical care specialists is crucial for improving patient outcomes. Early recognition and treatment contribute substantially to the prevention of recurrence and better long-term management of underlying conditions.
New insights on the shell-crusher shark Ptychodus decurrens Agassiz, 1838 (Elasmobranchii, Ptychodontidae) based on the first known articulated dentition from the Upper Cretaceous of Croatia
Authors: Amadori Manuel , Japundžić Sanja , Amalfitano Jacopo , Giusberti Luca , Fornaciari Eliana , Jambura Patrick L. , Kriwet Jürgen 
Published: January 2025

AbstractA new lower tooth plate of Ptychodus decurrens from the Turonian (Upper Cretaceous) of the Dalmatian region (southern Croatia) is documented here for the first time. The specimen represents the first articulated dentition of a ptychodontid shark that has been discovered from the Balkan Peninsula and the most complete ever found for the un-cuspidate species P. decurrens up to now. The reconstruction of the entire lower dentition of P. decurrens based on this exceptionally well-preserved dentition shows a wider crushing plate than previously hypothesised with bulgy teeth limited to the central area. Even though a defined cusp is missing, the occlusal surface of the teeth is undeniably raised and bulgy in some un-cuspidate species of Ptychodus (e.g., P. decurrens). This compels us to reconsider the use of terms such as high- and low-crowned as well as cuspidate and un-cuspidate. In addition, specimens previously assigned to dubious species (P. depressus, P. levis and P. oweni) or even varieties (P. polygyrus var. sulcatus and P. decurrens var. multiplicatus) are reassigned here to P. decurrens based on a careful comparison of the type materials. The reassessment of tooth root morphologies provides indicative traits for the identification of different genera of ptychodontid sharks (Paraptychodus and Ptychodus). The taxonomic revision presented here is crucial for securing a stable taxonomy and systematics of the shell-crushing shark P. decurrens, as well as of all ptychodontid sharks. The resulting updated taxonomy, together with the description and reconstruction of the new crushing plate, greatly contribute to a better understanding of one of the most enigmatic families (Ptychodontidae) of Mesozoic elasmobranchs. The detailed investigation of the new dentition of Ptychodus from Dalmatia is also a further step towards the discovery of Upper Cretaceous ichthyofaunas of one of the most palaeontologically important areas of the Balkan Peninsula.
Sex and gender in perioperative cardiovascular research: protocol for a scoping review
Authors: Sjaus Ana , Fakhory Nicole 
Published: January 2025

Abstract
Background
The inadequate inclusion of sex and gender in medical research has resulted in biased clinical guidance and disparities in knowledge and patient outcomes. Despite efforts by regulatory and funding agencies, opportunities to generate sex-specific knowledge are frequently overlooked. While certain disciplines in cardiovascular medicine have made notable progress, these advances have yet to permeate the literature on perioperative cardiovascular complications in non-cardiac surgery.
Prompted by the recent findings on sex-specific perioperative cardiovascular outcomes, this review aims to scope the literature in this field and categorize methodological approaches used to incorporate sex and gender in studies of this patient population.

Methods
Joanna Briggs Institute (JBI) methodology for scoping reviews will be followed in stages elaborated by Levac (2010). A comprehensive search strategy will be used to identify relevant primary research published since 2010. Screening will be performed by independent reviewers using predefined inclusion and exclusion criteria. Data will be extracted from full text and supplementary materials of selected articles. Results will be presented as proportions of studies reporting sex and gender, the assigned purpose of these variables in analysis, and where they are reported in the article. In addition, articles will be mapped to the source, country of origin, and year of publication. Narrative summaries will be provided to outline key findings and assess the depth of the literature within each of the major topics (risk assessment/prediction, diagnosis, treatment, prognosis, and outcomes).

Discussion
Increasing recognition of the profound and complex implications of sex and gender in medicine has fuelled calls for greater attention to participation equity, sex-specific analysis and reporting. Focusing on perioperative cardiovascular complications, this review has the potential to identify knowledge gaps for future research, as well as areas of strength that could support formal knowledge synthesis or secondary analysis of data from past research.

Scoping review registration
Submitted on August 15th, 2023 (Web of Science osf.io/u25sf)
Numerical Analysis of Shear Contribution of CFRP-Strengthened RC Beams by Different Bond-Slip Models
Authors: Ma Shengqiang , Sun Jianfeng , Xu Tiancai 
Published: January 2025

AbstractDuring a numerical investigation conducted using ABAQUS software, various bond-slip models for the FRP–concrete interface were evaluated to accurately predict the shear contribution of FRP in strengthening reinforced concrete (RC) beams. Three established bond-slip models were chosen to develop finite element analysis models for the four FRP-strengthened beams. The outcomes of these numerical simulations were subsequently compared with experimental data. The results demonstrated a strong correlation between the finite element simulations and the experimental tests, particularly regarding the failure process and shear capacity of the reinforced beams. The increase in shear capacity observed during testing varied from 13.5% to 42.9%. In contrast, the corresponding increase in shear capacity predicted by the finite element simulations ranged from 5.5% to 47.7%. The discrepancy in CFRP shear contribution among beams with different bond-slip relationships, under identical reinforcement configurations, was observed to be within the range of 0.1% to 15.9%. The numerical results of the Nakaba model showed a higher level of safety; however, the simulation performance of the Lu model was regarded as more effective and better suited for numerical analysis in predicting the shear contribution of FRP in strengthened RC beams.
A new species of Astragalus (Fabaceae) from the Irano-Turanian biodiversity hotspot: an integrative approach
Authors: Karbalaei Zahra , Bagheri Ali , Maassoumi Ali Asghar , Rutten Twan , Blattner Frank R. 
Published: January 2025

Abstract
Background
The genus Astragalus is the largest and one of the most diverse genera of flowering plants, particularly in the Northern Hemisphere, with a significant concentration of species in the Irano-Turanian region. Within this genus, section Hymenostegis is notable for its complexity and high levels of endemism, especially in northwestern Iran. During recent field explorations in West Azarbaijan province, a distinct population of Astragalus was identified, differing from known species within section Hymenostegis. This study aimes to describe and analyze this new species and clarify its relationship with closely related taxa using an integrative approach.

Results
Astragalus kuzehrashensis sp. nov. is described following detailed morphological comparisons with its closest relatives, A. chehreganii and A. hakkianus. The new species is distinguished by unique stipule characteristics, leaflet shape, inflorescence structure, and seed micromorphology. Molecular phylogenetic analysis using ITS and ycf1 sequences reveals that A. kuzehrashensis forms a clade with A. chehreganii and A. hakkianus, although it exhibits genetic differences. Genome size estimation confirms that A. kuzehrashensis is hexaploid (2n = 6x = 48), aligning it more closely with A. hakkianus than with the tetraploid A. chehreganii. The distinct morphological characters and genomic data support recognizing A. kuzehrashensis as a new species within section Hymenostegis.

Conclusions
The identification of A. kuzehrashensis underscores the importance of an integrative taxonomic approach, combining morphological, molecular, and cytogenetic data to resolve species boundaries within complex groups like Astragalus section Hymenostegis. This study highlights the rich biodiversity of the Irano-Turanian floristic region, emphasizing the need for ongoing exploration and conservation efforts, particularly in areas of high endemism. Our findings contribute to a deeper understanding of the taxonomy and evolutionary relationships within the genus Astragalus.
Understanding co-production of injury research in Australian Aboriginal and Torres Strait Islander communities: a comprehensive scoping review
Authors: Westacott Genevieve , McCreanor Victoria , Cramb Susanna , Manzanero Silvia , Vuong Kim , Allen Michelle , Dias Shannon , Binge Geoffrey , Das Arpita 
Published: January 2025

Abstract
Background
Injury causes significant burden on Australian Aboriginal and Torres Strait Islander communities. However, a considerable portion of the research conducted in this area has been carried out by Western researchers. It has been acknowledged that historical research methodologies and discourses around Aboriginal and Torres Strait Islander research may not be suitable or beneficial. Co-production methodologies offer opportunities for research to be developed collaboratively ensuring meaningfulness of results and appropriate protection for participants. A scoping review was undertaken to investigate the use of co-production methodologies in research within the unintentional injuries space for Australian Aboriginal and Torres Strait Islander communities over time.

Main body
A systematic search was conducted using PubMed, ProQuest, Embase and Indigenous Health Infonet databases. Study characteristics, remoteness, injury topic, co-production methods and elements were extracted from eligible studies. The search revealed 4175 papers, from which 39 studies were included in this scoping review. It was found that 69% of studies were fully co-produced with community. Studies predominately focused on general injury, falls prevention or brain injury rehabilitation. The most heavily utilised co-production strategy was the inclusion of Aboriginal and Torres Strait Islander researchers into the writing and research team. This helped the collection of culturally safe data and appropriate interpretation of results.

Conclusion
There is growing diversity among co-production methodologies, better enabling meaningful engagement between community and research. This co-production helps decolonise the research process to privilege Aboriginal voices, however, more work is needed to appropriately capture Indigenous perspectives.
Strategy of employing plug-and-play vectors and LC–MS screening to facilitate the discovery of natural products using Aspergillus oryzae
Authors: Shi Hanliang , Lin Beibei , Zheng Mengmeng , Gan Fengyu , Lin Zhi , Xin Xiujuan , Zhao Jian , Qu Xudong , An Faliang 
Published: January 2025

AbstractAspergillus oryzae is a widely used host for heterologous expression of fungal natural products. However, the vectors previously developed are not convenient for use and screening positive transformants by PCR and fermentation is time- and effort-consuming. Hence, three plug-and-play vectors were developed here for multi-gene expression and liquid chromatography mass spectrometry detection was introduced to screen positive transformants. Using rug BGC for verification, we demonstrated that the vectors we developed perform well and liquid chromatography mass spectrometry detection is feasible to screen positive transformants. For deleterious gene expression, PxyrA rather than PamyB was employed. Utilizing the toolkit described here to express natural products, dozen days can be saved.
Graphical Abstract
Reproductive health equity: demystifying unmet need for family planning among young women in Uttar Pradesh
Authors: Mishra Punit 
Published: January 2025

Abstract
Background
The unmet need for contraception among adolescent women in India is a significant public health concern, contributing to unintended pregnancies and abortions. This paper seeks to examine the regional variations and factors driving rural–urban disparities in unmet family planning needs in Uttar Pradesh (UP), India’s most populous state, where the total unmet need among adolescents is as high as 19%.

Methods
The study is based on 11,018 adolescent women from the recent round of India’s DHS, NFHS-5 (2019–21). To fulfil the study’s objective, Multilevel logit model and Oaxaca Blinder Decomposition was applied.

Results
The Multilevel logit model results show statistically significant variations at community and district level, implying a strong presence of unobserved factors affecting the unmet demand. Oaxaca decomposition results show that difference in rural and urban adolescent unmet need is explained by factors like wealth, religion and intra-state regions.

Conclusion
The results call for the need to implement culturally appropriate reproductive and sexual health literacy programs to increase uniform access to modern contraception and to raise women’s autonomy in the state of Uttar Pradesh.
Facial recognition payment is cool: coolness, inspiration, and customer continuance intention to use facial recognition payment
Authors: Gao Wei , Jiang Ning , Guo Qingqing 
Published: January 2025

AbstractFacial recognition payment (FRP), a new method of contactless payment, has attracted considerable attention over the past few years. However, the research on this topic remains nascent. This study assessed the drivers of customers’ FRP continuance intention from the perspectives of coolness and inspiration. We use online survey data from 610 Chinese FRP customers as the basis for our conceptual model. The results show that the coolness factors of subculture, attractiveness, utility, and originality have positive and significant effects on customers’ inspired-by states and that subculture and utility also promote inspired-to. Inspired-by is positively associated with inspired-to, which in turn enhances customers’ FRP continuance intention. Furthermore, the relationship between inspired-to and FRP continuance intention is negatively moderated by financial risk. In addition to contributing to the literature on FRP, coolness, and customer inspiration, this study offers several suggestions for implementing and developing FRP systems.
The role of the left primary motor cortex in apraxia
Authors: Perlova Ksenia , Schmidt Claudia C. , Fink Gereon R. , Weiss Peter H. 
Published: January 2025

Abstract
Background
Apraxia is a motor-cognitive disorder that primary sensorimotor deficits cannot solely explain. Previous research in stroke patients has focused on damage to the fronto-parietal praxis networks in the left hemisphere (LH) as the cause of apraxic deficits. In contrast, the potential role of the (left) primary motor cortex (M1) has largely been neglected. However, recent brain stimulation and lesion-mapping studies suggest an involvement of left M1 in motor cognitive processes—over and above its role in motor execution. Therefore, this study explored whether the left M1 plays a specific role in apraxia.

Methods
We identified 157 right-handed patients with first-ever unilateral LH stroke in the sub-acute phase (< 90 days post-stroke), for whom apraxia assessments performed with the ipsilesional left hand and lesion maps were available. Utilizing the maximum probability map of Brodmann area 4 (representing M1) provided by the JuBrain Anatomy Toolbox in SPM, patients were subdivided into two groups depending on whether their lesions involved (n = 40) or spared (n = 117) left M1. We applied a mixed model ANCOVA with repeated measures to compare apraxic deficits between the two patient groups, considering the factors “body part” and “gesture meaning”. Furthermore, we explored potential differential effects of the anterior (4a) and posterior (4p) parts of Brodmann area 4 by correlation analyses.

Results
Patients with and without M1 involvement did not differ in age and time post-stroke but in lesion size. When controlling for lesion size, the total apraxia scores did not differ significantly between groups. However, the mixed model ANCOVA showed that LH stroke patients with lesions involving left M1 performed differentially worse when imitating meaningless finger gestures. This effect was primarily driven by lesions affecting Brodmann area 4p.

Conclusions
Even though many current definitions of apraxia disregard a relevant role of (left) M1, the observed differential effect of M1 lesions, specifically involving subarea 4p, on the imitation of meaningless finger gestures in the current sample of LH stroke patients suggests a specific role of left M1 in imitation when high amounts of (motor) attention and sensorimotor integration are required.
Visual-inertial navigation assisted by a single UWB anchor with an unknown position
Authors: Luo Haolong , Zou Danping , Li Jiansheng , Wang Ancheng , Wang Li , Yang Zidi , Li Guangyun 
Published: January 2025

AbstractNavigation technology, which integrates vision, Inertial Measurement Unit (IMU), and Ultra-Wideband (UWB) sensors in GNSS-denied environments has gained a significant attention. However, inaccurate estimation of UWB anchor positions and improper sensor weighting among heterogeneous sensors significantly impairs the positioning accuracy and robustness of Visual-Inertial-UWB (VIU) systems. To accurately and rapidly estimate the UWB anchor positions, we employed the robust ridge nonlinear least-squares method to improve the accuracy and reliability of the estimated UWB anchor position. Additionally, we proposed a simple and effective method to assess the accuracy of the UWB anchor position using the geometric dilution precision principle, which facilitates rapid and accurate estimation of the UWB anchor position. Furthermore, we designed a method to calculate the estimated UWB anchor position error in real-world settings. Finally, we proposed a nonlinear optimization method with dynamically adaptive weighting based on the HELMERT variance component estimation principle, which assigns appropriate weights to heterogeneous sensors. To validate the feasibility and effectiveness of the proposed method, comprehensive simulations and real-world experiments were conducted. First, using Monte Carlo simulation and real-world experiments, we validated the effectiveness of the proposed methods for UWB anchor position and its accuracy estimation. Then, we conducted ablation experiments utilizing the open-source VIRAL and real-world datasets. The experimental results demonstrate that the proposed method exhibits superior positioning accuracy and robustness in contrast to the open-source VINS-MONO and VIR-SLAM methods.
A follow-up study of effect of type 2 diabetes mellitus on the cervical vestibular evoked myogenic potential
Authors: Chalotra Suman , Chandanshive Chandrahas , Bhagwat Nikhil 
Published: January 2025

Abstract
Background
Type 2 diabetes mellitus is a systemic disorder affecting glucose metabolism. It is known to impact neuronal function and lead to generalized neuropathy. This study aims to explore its effects on cervical vestibular evoked myogenic potentials, even after blood sugar levels are managed with appropriate treatment.

Methods
A pre-post follow-up study was conducted with 114 participants diagnosed with type 2 diabetes mellitus. Initial evaluations were performed before starting diabetes treatment, and a second evaluation occurred 3 months later, after blood sugar levels had been managed. A control group was established to compare the findings from the pre-treatment and post-treatment assessments of the study group.

Results
A significant decrease in sugar levels was observed after treatment. However, there was no notable difference between the pre-treatment and post-treatment indices of cervical vestibular evoked myogenic potentials in participants with diabetes mellitus. Additionally, participants consistently showed poorer results compared to the control group, both before and after treatment.

Conclusion
It can be inferred that elevated blood sugar levels have a lasting effect on the indices of cervical vestibular evoked myogenic potentials.