bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypomagnesemia and the risk of contrast-induced nephropathy in patients undergoing elective coronary angiography
Authors: ÖZBEYAZ Nail Burak , GÖKALP Gökhan , ALGUL Engin , AYDINYILMAZ Faruk , ŞAHAN Haluk Furkan , FELEKOĞLU Mehmet Ali , GULIYEV İlkin , İŞÇEN Sinan 
Published: February 2023

Objective: The present study aimed to assess the inﬂuence of hypomagnesemia (hypoMg) on the risk of developing contrast-induced nephropathy (CIN) after coronary angiography.
Methods: This is a single-center prospective, observational study conducted at a tertiary referral hospital. Between December 31, 2016, and February 28, 2021, 223 patients who had undergone coronary angiography procedures and had preprocedural baseline Mg levels were enrolled in this study. CIN was defined as an increase of >0.5 mg/dl or >25 % in serum creatinine concentration over baseline within 48-72 h after administration. HypoMg was deﬁned as Mg< 1.60 mg/dL.
Results: Of 223 patients enrolled, CIN occurred in 28 patients (12.6%). CIN occurred in 36.4 % of the patients with hypoMg and 11.3 % of those with non-hypoMg (P=0.02). Multivariate logistic regression analysis found that baseline Mg levels were independent predictors of CIN.
Conclusion: HypoMg was associated with an increased risk for CIN. These results suggest magnesium replacement in hypomagnesemia may be beneficially indicated before diagnostic/interventional studies using contrast media.
PENGARUH KUALITAS HUBUNGAN ANTARA ATASAN– BAWAHAN TERHADAP PERILAKU KERJA KONTRAPRODUKTIF Studi Pada Perawat Rumah Sakit Khusus Mata Palembang
Authors: Budiman Budiman 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Kualitas hubungan antara atasa- bawahan terhadap perilaku laku kerja kontraproduktif. Penelitian ini dilakukan di Rumah Sakit Khusus Mata Palembang dengan perawat sebagai subjek penelitian. jumlah subjek penelitian sebanyak 67 perawat di bagian pelayanan dan rawat inap. Alat pengumpul data yang digunakan dalam penelitian ini adalah Skala Perilaku Kerja Kontraproduktif dari Spector dkk (2006) dan Skala Kualitas Hubungan antara Atasan-bawahan dari Leden dan Maslyn (1998). Hasil pengolahan data dengan menggunakan teknik analisis regresi diperoleh bahwa terdapat pengaruh yang signifikan kualitas hubungan antara atasan-bawahan terhadap perilaku kerja kontraproduktif. Berdasarkan analisis data diperoleh angka -0,537 dengan taraf sigifikansi 0.004, artinya terdapat pengaruh negatif kualitas hubungan antara atasan-bawahan terhadap perilaku kerja kontraproduktif pada perwat Rumah Sakit Khusus Mata Palembang. Bila kualitas hubungan atasa-bawahan baik maka akan mampu menurunkan perilaku kerja kontraproduktif.
MOLECULAR MECHANISMS UNDERLYING THERAPEUTIC ACTION OF VITAMIN B6
Authors: Zagubnaya O. A. , Nartsissov Y. R. 
Published: February 2023

The aim of the study was to analyze the molecular mechanisms that determine the possibility of using vitamin B6 in clinical practice for the correction of various pathological conditions.Materials and methods. Information retrieval (Scopus, PubMed) and library (eLibrary) databases were used as research tools. In some cases, the ResearchGate application was used for a semantic search. The analysis and generalization of the scientific literature on the topic of research, covering the period from 1989 to the present, has been carried out in the work.Results. It has been shown that all chemical forms of vitamin B6 are able to penetrate the membranes of most cells by free diffusion, while forming phosphorylated forms inside. Pyridoxal phosphate is a biologically important metabolite that is directly involved as a cofactor in a variety of intracellular reactions. Requirements for this cofactor depend on the age, sex and condition of the patient. Pregnancy and lactation play a special role in the consumption of vitamin B6. In most cases, a balanced diet will provide an acceptable level of this vitamin. At the same time, its deficiency leads to the development of a number of pathological conditions, including neurodegenerative diseases, inflammations and diabetes. Negative manifestations from the central nervous system are also possible with an excessive consumption of B6.Conclusion. Replenishment of the vitamin B6 level in case of its identified deficiency is a necessary condition for the successful treatment of the central nervous system diseases, diabetes and correction of patients’ immune status. At the same time, it is necessary to observe a balanced intake of this cofactor in order to avoid negative effects on metabolism in case of its excess.
Orthopaedic Operating Room Fire Risks
Authors: Carmack David , Hegeman Erik , Vizurraga David 
Published: February 2023

» Inadvertent activation of electrosurgical device was more likely to result in patient burns and harm.» There are significant knowledge gaps in the orthopaedic surgery community relating to fire prevention, fire safety, and fire management.» Arthroplasty was the most common procedure with reported fire events.» It is the responsibility of the orthopaedic surgeon to understand the risks of surgical fire in the operating room and implement actions to reduce those risks.
The Swiss Spinal Cord Injury Cohort Study (SwiSCI) Biobank: from concept to reality
Authors: Stoyanov Jivko , Zeh Ramona , Glisic Marija , Capossela Simona , Bertolo Alessandro , Valido Ezra , Stucki Gerold , Pannek Jürgen , Eriks-Hoogland Inge , Jordan Xavier , Hund-Georgiadis Margret 
Published: February 2023

Abstract
Objectives
To describe the concept, establishment and the operationalization of the biobank of the Swiss Spinal Cord Injury Cohort Study (SwiSCI), the available biosamples, and demographic and clinical characteristics of study participants.
Setting:
The SwiSCI biobank is a platform for research within SwiSCI. It collects and processes serum, plasma, PBMCs, RNA, DNA, and urine from three rehabilitation centers. Samples are collected at admission to first rehabilitation and at discharge. Additionly, the biobank provides services to projects nested in SwiSCI or otherclinical trials among Spinal Cord Injury population.
Methods
Descriptive statistics were used for an overview of available biosamples, study participant characteristics, and comparison of the participating centers.
Results
Since the biobank establishment 232 (49.5%) individuals agreed to provide biosamples. As of 22nd March 2022, 217 SCI individuals went through first inpatient rehabilitation. Among these, the mean age of study participants was 50.74 (± 17.1) years old, the majority were male (78.34%) with traumatic injury (65.44%) and paraplegic (56.22%), 47.93% with motor-complete injury. The median SCIM score was 29 (IQR 19–49). The percentage of individuals with paired samples at both time points (beginning and end of rehabilitation) ranged from 63.59% (for RNA) to 68.66% (for urine and urine sediment).
Conclusions
The SwiSCI Biobank is a unique platform designed to serve as a basis for collaborative SCI research, including multi-omics approaches. Longitudinality of biosamples collection and cryopreservation of multiple aliquots per individual are key for studying temporality of associations, assuring reproducibility of research and acheiving adequate sample size.
“Because it is a rare disease…it needs to be brought to attention that there are things out of the norm”: A qualitative study of patient and physician experiences of Wilson disease diagnosis and management in the US
Authors: Bailey Karen , Sahota Navdeep , To Uyen , Hedera Peter 
Published: February 2023

Abstract
Background
Wilson disease (WD) is a genetic disorder of copper metabolism that leads to copper accumulation in various organs, primarily the liver and brain, resulting in heterogenous hepatic, neurologic, and psychiatric symptoms. Diagnosis can occur at any age, often leading to lifelong treatment. This qualitative study aims to understand the wider patient and physician experience of the diagnosis and management of WD in the US.
Methods
Primary data were collected from 1:1 semi structured interviews with US-based patients and physicians and thematically analyzed with NVivo.
Results
Twelve WD patients and 7 specialist WD physicians (hepatologists and neurologists) were interviewed. Analysis of the interviews revealed 18 themes, which were organized into 5 overarching categories: 1) Diagnosis journey, 2) Multidisciplinary approach, 3) Medication, 4) The role of insurance, and 5) Education, awareness, and support. Patients who presented with psychiatric or neurological symptoms reported longer diagnostic journeys (range 1 to 16 years) than those presenting with hepatic symptoms or through genetic screening (range 2 weeks to 3 years). All were also affected by geographical proximity to WD specialists and access to comprehensive insurance. Exploratory testing was often burdensome for patients, but receipt of a definitive diagnosis led to relief for some. Physicians emphasized the importance of multidisciplinary teams beyond hepatology, neurology, and psychiatry and recommended a combination of chelation, zinc, and a low-copper diet; however, only half the patients in this sample were on a chelator, and some struggled to access prescription zinc due to insurance issues. Caregivers often advocated for and supported adolescents with their medication and dietary regimen. Patients and physicians recommended more education and awareness for the healthcare community.
Conclusions
WD requires the coordination of care and medication among several specialists due to its complex nature, but many patients do not have access to multiple specialties due to geographical or insurance barriers. Because some patients cannot be treated in Centers of Excellence, easy access to reliable and up-to-date information is important to empower physicians, patients, and their caregivers in managing the condition, along with general community outreach programs.
Controlling needle insertion inside hydrogel structures to generate vascularized tissue engineered constructs
Authors: Barua Ranjit , Chowdhury Amit Roy , Datta Pallab 
Published: February 2023

AbstractVascularization is a critical limitation for the translation of tissue engineered constructs. However, automated, direct fabrication of hollow, vascular-like channels inside tissue-like gel substances remains a challenge for manufacturing science. A proposed method is to employ a robotic-arm controlled 3D printer to navigate user-defined needle tips within the gel materials. In this work, a simulation model for the needle-gel contact process is developed and experimentally validated, to generate hollow channel inside gels. Optimization of navigation forces is performed to predict the amount of insertion force and deflection. It has been found that needle navigation depends on parameters such as geometrical shape of needle tip, variation in speed and gel properties. Insertion force was found to increase with increase in needle speed while large needle diameters were found to generate large insertion forces. On the other hand, needle deflection was found to decrease with increase in the needle diameter as well as velocity of the insertion. Moreover, due to the non-isometric shape, a bevel-shaped needle tip showed larger deflection than conical needle tip. It is concluded that the developed model can simulate needle navigation process in different gel material and thus, lays the foundation for further development of manufacturing modality for fabrication of hollow channels in tissue engineered constructs. This may also find application for fabrication of sub-surface, enclosed microfluidic channels.
Self-supervised robot self-modeling using a single egocentric camera
Authors: Hu Yuhang , Chen Boyuan , Lipson Hod 
Published: February 2023

Abstract
The ability of robots to model their own dynamics is key to autonomous planning and learning, as well as for autonomous damage detection and recovery. Traditionally dynamic models are pre-programmed, or learned from external observations and IMU data. Here, we demonstrate for the first time how a task-agnostic dynamic self-model can be learned using only a single first-person-view camera in a self-supervised manner, without any prior knowledge of robot morphology, kinematics, or task. We trained an egocentric visual self-model using random motor babbling on a 12-DoF robot. We then show how the robot can leverage its visual self-model to achieve various locomotion tasks, such as moving forward, backward and turning, all without any additional physical training. The accuracy of the egocentric model exceeds that of a model trained using an IMU. We also show how a robot can automatically detect and recover from damage. We suggest that self-supervised egocentric visual self-modeling could allow complex systems to continuously model themselves without additional sensors and prior knowledge.
Comparison of earthquake catalogs declustered from three different methods in the Korean Peninsula
Authors: Kim Sung Kyun 
Published: February 2023

Abstract
The earthquake catalog includes both dependent earthquakes, which are spatio-temporally related to each other, and independent or background earthquakes. In order to predict the long-term seismicity or perform seismic hazard research, the dependent earthquakes must be removed to generate a declustered earthquake catalog. However, several declustering methods have been proposed, and the evaluation of seismic hazard may vary depending on the selected declustering method. In the present study, the catalog of earthquakes that were observed between 2016 and 2021 in and around the Korean peninsula is declustered using the methods of Gardner and Knopoff (1974), Reasenberg (1985), and Zhuang et al. (2002), and the resultant catalogs are compared. The values of the seismicity parameters (a and b) in the Gutenberg-Richter relationship are estimated from the declustered catalogs, and are seen to vary depending on the declustering method, thereby affecting the results of long-term earthquake prediction or seismic hazard analysis.
In addition, three approaches are used to test whether the original (raw) and declustered catalogs follow the Poisson process or not. The minimum magnitude (Mp) above which the null hypothesis of the Poisson process cannot be rejected in the earthquake catalog is shown to range from 1.6 to 2.2 depending on the declustered catalog and the test method used. Further, the Mp obtained herein shows a large value compared to the completeness magnitude estimated in the present study. A comparison of the curves representing the cumulative number of background earthquakes versus the elapsed time for the various declustered catalogs shows that the method of Zhuang et al. (2002) gives the closest agreement with the real background seismicity curve.
Quality of Life and Psychometric Characteristics of Syrian Refugee Physicians Who Migrated to Turkey: A Cross-sectional Study
Authors: KESKIN Ahmet , DAGCIOGLU Basri Furkan 
Published: February 2023

Abstract
Background: The concept of migration comes with various problems, affecting the quality of life and psychological state of immigrants. This study aimed to investigate the quality of life and depression and anxiety states of physicians who immigrated to Turkey after the civil war that started in Syria in 2011.
Methods: In this cross-sectional study, a socio-demographic questionnaire form, the short version of the World Health Organization’s quality of life assessment tool (WHOQOL-BREF), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to Syrian doctors who received integration training to work in refugee health centers established for immigrants in Turkey.
Results: A total of 570 participants were included in the study. The median scores of WHOQOL-BREF domains of the participants were 75 for DOM1 (min:25, max:100, IQR:18), 69 for DOM2 (min:6, max:100, IQR:25), 69 for DOM3 (min:0, max:100, IQR:19) and 63 for DOM4 (min:0, max:94, IQR:19). The median BDI score of the participants was 7 (min:0, max:41, IQR:8), and the median BAI score was 5 (min:0, max:50, IQR:8). Having primary care experience, having knowledge about the Turkish health system, believing that they can adapt to work in refugee health centers and not having a plan to return to their country were found to be associated with a higher score in at least one of the WHOQOL-BREF sub-domains. Planning to turn back their country was significantly associated with higher BAI scores.
Conclusions: The quality of life of refugee physicians in Turkey was higher than that of refugees in a similar situation. In addition, BDI and BAI scores were below the expected values. Further qualitative studies that allow in-depth analyses may reveal underlying factors for this situation.
The REBURN model: Simulating system-level forest succession and wildfire dynamics
Authors: Prichard Susan J , Salter R. Brion , Hessburg Paul F. , Povak Nicholas A. , Gray Robert W 
Published: February 2023

Abstract
Background: Historically, reburn dynamics from cultural and lightning ignitions were central to the historical ecology of fire in the western United States (wUS), whereby past fire effects limited future fire growth and severity. Over millennia, reburns created heterogenous patchworks of vegetation and fuels that provided avenues and impediments to the flow of future fires, and feedbacks to future fire event sizes and their severity patterns. These dynamics have been significantly altered after more than a century of settler colonization, fire exclusion, and past forest management, now compounded by rapid climatic warming. Under climate change, the area impacted by large and severe wildfires will likely increase – with further implications for self-regulating properties of affected systems. An in-depth understanding of the ecology of reburns and their influence on system-level dynamics provides a baseline for understanding current and future landscape fire-vegetation interactions.
Results: Here, we present a detailed characterization of REBURN – a geospatial modeling framework designed to simulate reburn dynamics over large areas and long time frames. We interpret fire-vegetation dynamics for a large testbed landscape in eastern Washington State, USA. The landscape is comprised of common temperate forest and nonforest vegetation types distributed along broad topo-edaphic gradients. Each pixel in a vegetation type is represented by a pathway group (PWG), which assigns a specific state-transition model (STM) based on that pixel’s biophysical setting. STMs represent annualized vegetation and fuel succession, and wildfire effects on succession. Wildfire dynamics are driven by annual ignitions, fire weather and topographic conditions, and annual vegetation and fuel successional states of burned and unburned pixels.
Conclusions: Our simulation study is the first to evaluate how fire exclusion and forest management altered the active fire regime of this landscape, its surface and canopy fuel patterns, forest and nonforest structural conditions, and the dynamics of forest reburning. The REBURN framework will be used in future studies to evaluate future climate change scenarios and compare the efficacy of fire management strategies that either enable the return of active fire regimes or depend on fire suppression and their effects on forest burning.
Loss of HES1 Expression is Associated with Extracellular Matrix Remodeling and Tumor Immune Suppression in KRAS Mutant Colon Adenocarcinomas
Authors: Wang Lei , Gu Wenchao , Kalady Matthew , Xin Wei , Zhou Lan 
Published: February 2023

Abstract
The loss of HES1, a canonical Notch signaling target, may cooperate with KRAS mutations to remodel the extracellular matrix and to suppress the anti-tumor immune response. While HES1 expression is normal in benign hyperplastic polyps and normal colon tissue, HES1 expression is often lost in sessile serrated adenomas/polyps (SSAs/SSPs) and colorectal cancers (CRCs) such as those right-sided CRCs that commonly harbor BRAF or KRAS mutations. To develop a deeper understanding of interaction between KRAS and HES1 in colorectal carcinogenesis, we selected microsatellite stable (MSS) and KRAS mutant or KRAS wild type CRCs that show aberrant expression of HES1 by immunohistochemistry. By comparing the transcriptional landscapes of microsatellite stable (MSS) CRCs with or without nuclear HES1 expression, we investigated differentially expressed genes and activated pathways. We identified pathways and markers in the extracellular matrix and immune microenvironment that are associated with mutations in KRAS. We found that loss of HES1 expression positively correlated with matrix remodeling and epithelial-mesenchymal transition (EMT) but negatively correlated with tumor cell proliferation. Furthermore, loss of HES1 expression in KRAS mutant CRCs correlates with a higher M2 macrophage polarization and activation of IL6 and IL10 immunosuppressive signature. Identifying these HES1-related markers may be useful for prognosis and developing treatment of KRAS-mutant CRCs.
Smartphone intervention to optimize medication assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial
Authors: Thompson Ron G , Bollinger Mary , Mancino Michael J , Hasin Deborah , Han Xiaotong , Bush Keith A , Kilts Clint D , James George Andrew 
Published: February 2023

Abstract
Background: Opioids accounted for 75% of drug overdoses in the United States in 2020, with rural states particularly impacted by the opioid crisis. While medication assisted treatment (MAT) with Suboxone remains one of the more efficacious treatments for opioid use disorder (OUD), approximately 40% of people receiving Suboxone for outpatient MAT for OUD (MOUD) relapse within the first 6 months of treatment. We developed the smartphone app-based intervention OptiMAT as an adjunctive intervention to improve MOUD outcomes. The aims of this study are to (1) evaluate the efficacy of adjunctive OptiMAT use in reducing opioid misuse among people receiving MOUD; and (2) evaluate the role of specific OpitMAT features in reducing opioid misuse, including the use of GPS-driven just-in-time intervention.
Methods: We will conduct a two-arm, single-blind, randomized controlled trial of adults receiving outpatient MOUD in the greater Little Rock AR area. Participants are English-speaking adults ages 18 or older recently enrolled in outpatient MOUD at one of our participating study clinics. Participants will be allocated via 1:1 randomized block design to (1) MOUD with adjunctive use of OptiMAT (MOUD+OptiMAT) or (2) MOUD without OptiMAT (MOUD-only). Our blinded research statistician will evaluate differences between the two groups in opioid misuse (as determined by quantitative urinalysis conducted by clinical lab staff blinded to group membership) during the 6-months following study enrolment. Secondary analyses will evaluate if OptiMAT-usage patterns within the MOUD+OptiMAT group predict opioid misuse or continued abstinence.
Discussion: This study will test if adjunctive use of OptiMAT improve MOUD outcomes. Study findings could lead to expansion of OptiMAT into rural clinical settings, and the identification of OptiMAT features which best predict positive clinical outcome could lead to refinement of this and similar smartphone appbased interventions.
Trial registration: ClinicalTrials.gov identifier: NCT05336188, registered March 21, 2022, https://clinicaltrials.gov/ct2/show/NCT05336188.