bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cost of Illness Study of Saudi Healthcare System Spending on Quarantining Patients with Monkeypox Virus
Authors: Alshahrani Ali 
Published: December 2022

Abstract
Quarantine is a popular public health intervention often used to curb pandemics involving infectious diseases that threaten to spread across a population. However, the economic implications of enforcing quarantine have sparked debate on its justifiability, particularly with less severe infectious viruses. This research seeks to estimate the direct and indirect costs needed to set up a quarantine facility to curb the spread of the Monkey Pox virus. To do so, the study simulates a quarantine facility housing 100 Monkey Pox virus patients in Saudi Arabia for the incubation period (14 days). The direct costs include accommodation expenses and treatment costs.
On the other hand, the indirect costs of implementing a quarantine are measured in terms of lost productivity after the infected population fails to attend work. The direct and indirect costs of the quarantine were almost similar, $152,500 and $129,500, respectively. However, most of the direct costs ($150,000) include accommodation expenses. Hence, if a patient were to self-isolate at home, the indirect costs of quarantine would by far surpass the direct costs. Thus, the study concludes that enforcing quarantine would adversely affect the economy due to job absenteeism. Hence, considering that the Monkey Pox virus poses a low risk to the public and can be cured with no or affordable prescriptions, other strategies such as mass vaccinations, remote working, and routine hygiene practices should instead be used to tame the spread of the virus.
Contamination of polychlorinated biphenyls and hexachlorobutadiene in greenhouse and open-field agricultural soils across China
Authors: Yaru Li , Lan Jing , Zhao Zongshan 
Published: December 2022

Abstract
Combined with the physical isolation feature of greenhouse, the popularization of greenhouse throughout China makes the pollution of greenhouse soils more noteworthy as a result of its high yielding food exposed to human beings. Here, a national-scale survey was conducted to evaluate the contamination status, contaminated sources and human health risks of polychlorinated biphenyls (PCBs) and hexachlorobutadiene (HCBD) in greenhouse and open-field soils of 20 regions across China. The PCBs contents ranged from <LOD to 673.78 ng/g with the mean content of 77.38 ng/g in greenhouse soils and ranged from <LOD to 552.53 ng/g with the mean content of 61.90 ng/g in open-field soils. The HCBD contents ranged from 0.85 ng/g to 24.18 ng/g with the mean content of 8.33 ng/g in greenhouse soils and ranged from <LOD to 20.19 ng/g with the mean content of 6.39 ng/g in open-field soils. Among divided seven regions, higher levels of PCBs in greenhouse and open-field soils were found in north and south China. Furthermore, in most regions, correlation analysis indicated that soil PCBs in greenhouse and open-field were likely from the same emission sources. Higher levels of soil pollutants in greenhouse than in open-field may be contributed to the limited air-soil exchange. Compared with higher levels of ΣPCBs in greenhouse soils, the health risks of ΣPCBs in open-field soils were higher due to the higher percentages of high-toxicity PCBs, especially for the carcinogenic risks to children (> 10-6). This study provided a full insight into the contamination status and risks of PCBs and HCBD when guiding greenhouse agriculture activities.
Postconditioning with mild hypoxia induces HIF-1a express and improves neurobehavioral ability of mice with Hypoxia-ischemic brain damage
Authors: deng qingqing , chang yanqun , Cheng Xiaomao , Luo Xingang , li Yan , Tang Xiaoyuan 
Published: December 2022

Abstract
Background
While severe hypoxia is known to contribute to neurotoxicity and lead to abnormal behavior, mild hypoxia may have beneficial effects mediated through endogenous adaptive responses.
Objective
To investigate the effects of postconditioning with mild hypoxia on brain damage and long-term neurobehavioral ability recovery after hypoxia ischemic brain damage.
Method
Seven-day-old mice underwent left carotid ligation followed by 2 h of hypoxic stress. Mice received different protocols of postconditioning with repeated mild hypoxia for 3 weeks and underwent neurobehavioral testing during the last week of the study. Hypoxia-inducible factor 1 alpha (HIF-1a) expression was assessed and neurobehavioral ability assays were performed.
Result
Compared to the HIBD group, mice postconditioning with mild hypoxia had elevated HIF-1a expression and their brain functioned better in neurobehavioral analyses. The recovery of the brain function may be directly related to the higher HIF- 1a expression and better behavioral performance.
Conclusion
Our findings indicate that postconditioning mild hypoxia improves neurobehavioral ability and HIF-1a may be a potential mediator of the observed effects. Our results may have clinical implications for treating infants with HIBD.
Hyperfluorescence of choroidal arteries in periphery (HCAP) on late-phase ICGA
Authors: Li Miaoling , Zhang Xiongze , Ji Yuying , Mi Lan , Wen Feng 
Published: December 2022

Abstract
Aims
To correlate the hyperfluorescent lines in periphery on late-phase indocyanine green angiography (ICGA) to infrared and optical coherence tomography (OCT) findings.
Methods
This is a retrospective, cross-sectional study. Multimodal imaging data of patients, including ICGA, fluorescein angiography, infrared imaging, and OCT were analyzed. The hyperfluorescent lines were categorized into 2 grades according to their extents. In addition, non-fasting serum level of apolipoprotein A (ApoA) and apolipoprotein B (ApoB) were measured by enzyme linked immunosorbent assay.
Results
A total of 247 patients who underwent multimodal imaging were reviewed. The hyperfluorescent lines in periphery on late-phase ICGA were detected in 96 patients, and were correlated to superficial choroidal arteries by infrared imaging and OCT. The incidence of hyperfluorescent choroidal arteries in periphery (HCAP) on late-phase ICGA increased in groups of older ages (0–20 years, 4.3%; 20–40 years, 2.6%; 40–60 years, 48.9%; >60 years, 88.7%; p < 0.001). In addition, the mean age increased with the grades of HCAP (grade 1, 52.3 ± 10.8 years; grade 2, 63.3 ± 10.5 years; p < 0.001). The hyperfluorescence was also detected in posterior choroidal arteries in 11 eyes, all patients in grade 2. There was no significant correlation between grades of HCAP and gender, or serum level of ApoA and ApoB.
Conclusion
HCAP is an age-related change. The superficial location of choroidal arteries in periphery exposes their hyperfluorescence on late-phase ICGA. HCAP might reveal the local lipid degeneration of choroidal artery walls, according to the binding property of ICG molecules.
How to Evoke Empathetic Experience and Deepen Impression: The role of profile pictures in social media
Authors: Liu Yong-Jin , Liu Xinge , Zhou Chao , Zhang Shu , Liu Niqi , Liu Zixi , Wang Shaocong , Yu Minjing 
Published: December 2022

Abstract
Profile pictures are perceived as a form of social identity and individuals often engage in similar categorization processes. Profile pictures in social media represent virtual identities in online social networks and embody personal impression. The influence of profile picture styles on empathy plays an important role in the design and user experience of social media. However, the potential impact of profile pictures with different image styles (e.g., cartoon faces, real faces, or non-face images) on the perception of users in social media is still unclear. To investigate this impact, a controlled laboratory experiment (48 participants) and an ecological online experiment (184 participants) were conducted. Results show that participants’ empathic experience for users choosing cartoon faces or real faces as profile pictures are greater than that for users choosing non-face images. Besides, participants performed better in identity recognition for users choosing real face or non-face images than those choosing cartoon faces. Increasing empathic experience was associated with the degree to which users choosing profile pictures are categorized as ingroup members. Users of social media often make social categorizations (i.e., ingroup/outgroup categorization) based on the social identities expressed by their profile pictures. Our results also showed that increasing empathic experience was associated with the degree to which users choosing profile pictures are categorized as ingroup members.
Existential Anxiety of Nurses in the Corona-Virus Units and Its Relation with Resilience and Posttraumatic Growth: A Survey in Southeast Iran
Authors: Nasab Farshid Rafiee Sarbijan , Ghonchehpour Asma , Maghsoudi Fatemeh , Mehdipour-Rabori Roghayeh 
Published: December 2022

Abstract
Background
The study aimed to investigate the relationship between existential anxiety, post-traumatic growth, and resilience in nurses working in COVID-19 units of hospitals affiliated to Kerman University of Medical Sciences.
Methods
This was a Descriptive-analytical study. The researchers conducted this study on 224 nurses working in the COVID-19 units of four hospitals affiliated to Kerman University of Medical Sciences in Southeast Iran from 2020 to 2021. They collected data using demographic questionnaire, Masoudi Sani et al.'s existential anxiety questionnaire, Conner-Davidson resilience scale, post-traumatic growth inventory. They also used SPSS V 25 to analyze data.
Results
The results suggested that the mean score of existential anxiety was 80.92 ± 9.18, the mean resilience score was 63.51 ± 15.00, and the mean post-traumatic growth score was 87.69 ± 16.55. The results showed no statistically significant relationship between existential anxiety, resilience, and post-traumatic growth (P > 0.005) but a negative and significant relationship between post-traumatic growth and resilience (P < 0.001, r=-0.38). there were no statistical relationship between the mean existential anxiety score, age, sex, and education level, but the mean existential anxiety score in the emergency personnel was significantly higher than that in those of other departments.
Conclusion
The results demonstrated that the mean scores of existential anxiety and resilience were moderate, while post-traumatic growth score was high. The researchers suggest educational and interventional measures to improve resilience and reduce existential anxiety among nurses.
Propranolol-induced apoptosis via the AKT signaling pathway in epithelial ovarian cancer
Authors: Tao Yin , Chen Yin , Liu Fieya , Lai Xuanyin , Wang Xin , Zhu Qiong 
Published: December 2022

Abstract
Objective: This study aims to explore whether the effect of propranolol on the viability and apoptosis of ovarian cancer cells is mediated by inhibiting AKT signaling pathway.
Methods: SKOV-3 ovarian cancer cell was treated with 0, 25, 50, 100, 200 and 400μM propranolol hydrochloride for 0, 24, 48, and 72 h, and then the cell viability was detected by CCK-8. After treating SKOV-3 cells with 0, 50, 100, and 200μM propranolol for 24h, Q-PCR detected the mRNA levels of BCL-2, BAX, and AKT. Western blotwas employed to detect the protein expression of caspase-3 and AKT. The activator N-oleoylglycine and the inhibitor A2D5363 were combined with propranolol to treat SKOV-3 cells for 24h. Western blot detected the protein expression of AKT and CCK-8 method was used to detect cell proliferation.
Results: Propranolol inhibited the proliferation of SKOV-3 cells in a concentration- and time-dependent manner. In addition, propranolol promoted the expressions of BAX and caspase-3 and inhibited BCL-2 and AKT. Propranolol combined with AKT inhibitor A2D5363 enhanced the propranolol anti-ovarian cancer effect and the combined with AKT activator N-Oleoylglycine reduced the anti-ovarian cancer effect of propranolol.
Conclusions: Propranolol-induced apoptosis of ovarian cancer is mediated by inhibiting the AKT signaling pathway.
A Link Prediction-based Recommendation System using Transactional Data
Authors: Yilmaz Emir Alaattin , Balcisoy Selim , Bozkaya Burcin 
Published: December 2022

Abstract
Recommending relevant items to users has become an important task in many systems due to the increased amount of data produced. For this purpose, transaction datasets such as credit card transactions and e-commerce purchase histories can be used in recommendation systems to understand underlying user interests by exploiting user-item interactions, which can be a powerful signal to perform this task. This study proposes a link prediction-based recommendation system combining graph representation learning algorithms and gradient boosting classifiers for transaction datasets. The proposed system generates a network where nodes correspond to users and items, and links represent their interactions. A use case scenario is examined on a credit card transaction dataset as a merchant prediction task that predicts the merchants where users can make purchases in the next month. Performances of common network embedding extraction techniques and classifier models are evaluated via various experiments conducted and based on these evaluations, a novel system is proposed, and a matrix factorization-based alternative recommendation method is compared with the proposed model. The proposed method has shown superior performance to the alternative method in terms of receiver operating characteristic curves, area under the curve, and mean average precision metrics. The use of transactional data for a recommendation system is found to be a powerful approach to making relevant recommendations.
Safety and Feasibility of Percutaneous Needle Tunneling with Platelet-rich Plasma Injections for Peyronie's Disease in the Outpatient Setting: A Prospective Cohort Study
Authors: Zugail Ahmed S. , Alshuaibi Muaath , Lombion Sandrine , Beley Sébastien 
Published: December 2022

AbstractThe objective of this study is to evaluate the safety and feasibility of the combined simultaneous percutaneous needle tunneling (PNT) coupled with injection of platelet-rich plasma (PRP) for the treatment of Peyronie’s disease (PD). This prospective cohort study included patients who underwent this procedure from November 2020 to July 2022. The main outcome was an improvement in penile curvature that facilitated intercourse. Fifty-four patients enrolled and underwent 6 sessions of PNT/PRP followed by vacuum therapy for the treatment of PD in our outpatient department (OPD). The amendment of the curvature angle was significant with a median correction percentage of 44.4% (p = 0.001). None required any pain medication and pain disappeared within 24 hours in all patients. All patients reported less difficulty during sexual intercourse. In our experience PNT/PRP in the OPD is a safe, effective and feasible treatment of penile deformity for PD that facilitates sexual intercourse.
Oncogenic role of SATB2 in prostate cancer: Regulator of pluripotency, self-renewal and epithelial-mesenchymal transition
Authors: Srivast Rakesh , Yu Wei , Srivast Rashmi , Ma Yiming , Boinpelly Varun , Mores Grace , Shankar Sharmila 
Published: December 2022

Abstract
Special AT-rich sequence binding protein-2 (SATB2) is a nuclear matrix protein that binds to nuclear attachment regions and is involved in chromatin remodeling and transcription regulation. In stem cells, it regulates the expression of genes required for maintaining pluripotency and self-renewal and epithelial-mesenchymal transition (EMT). In this study, we examined the oncogenic role of SATB2 in prostate cancer, and assess whether overexpression of SATB2 in human normal prostate epithelial cells (PrECs) induces properties of cancer stem cells (CSCs). The results demonstrate that SATB2 is highly expressed in prostate cancer cell lines and CSCs, but not in PrECs. Overexpression of SATB2 in PrECs induces cellular transformation which was evident by the formation of colonies in soft agar and spheroids in suspension. Overexpression of SATB2 in PrECs also resulted in induction of stem cell markers (CD44 and CD133), pluripotency maintaining transcription factors (cMyc, Oct4, Sox2, KLF4, and Nanog), cadherin switch and EMT-related transcription factors. Chromatin immunoprecipitation assay demonstrated that SATB2 can directly bind to promoters of Bcl-2, Bsp, Nanog, XIAP, KLF4 and HOXA2, suggesting SATB2 is capable of directly regulating pluripotency/self-renewal, cell survival and proliferation. Since prostate CSCs play a crucial role in cancer initiation, progression, and metastasis, we also examined the effects of SATB2 knockdown on stemness. SATB2 knockdown in prostate CSCs inhibited spheroid formation, cell viability, colony formation, cell motility, migration, and invasion compared to their scrambled control groups. SATB2 knockdown in CSCs also upregulated the expression of E-Cadherin and inhibited the expression of N-Cadherin, Snail, Slug, and Zeb1. The expression of SATB2 was significantly higher in prostate adenocarcinoma compared to normal tissues. Overall, our data suggest that SATB2 acts as an oncogenic factor where it is capable of inducing malignant changes in PrECs by inducing CSC characteristics.
An agarose-alginate microfluidic device for the study of spheroid invasion, ATRA inhibits CAFs-mediated matrix remodeling
Authors: Nasiraee Mohammad Reza , Shahrivari Shabnam , Sayad Soheila , Mahdavi Hoda , Saraygord‐Afshari Neda , Bagheri Zeinab 
Published: December 2022

Abstract
Growing evidence demonstrates that cancer-associated fibroblasts (CAF) are responsible for tumor genesis, growth, metastasis, and treatment response. Therefore, targeting these cells may contribute to tumor control. It has been proposed that targeting key molecules and pathways of proliferative functions can be more effective than killing CAFs. In this regard, multicellular aggregates, like spheroids, can be used as human tumor models. Spheroids closely resemble human tumors and mimic many of their features. Microfluidic systems are ideal for cultivation and study of spheroids. These systems can be designed with different biological and synthetic matrices in order to have a more realistic simulation of the tumor microenvironment (TME). In this study, we investigated the effect of all-trans retinoic acid (ATRA) on 3D spheroid invasion of MDA-MB cells exposed to hydrogel matrix derived from CAFs. The number of invasive cells significantly decreased in CAF-ECM hydrogel treated with ATRA (p < 0.05), which indicates that ATRA could be effective for CAFs normalization. This experiment was done using an agarose-alginate microfluidic chip. As compared with common methods, such hydrogel casting is an easier method for chip fabrication and can even reduce costs by 50%.
Outcome and characteristics of nonsecretory multiple myeloma compared with secretory multiple myeloma: A retrospective multicenter study from China
Authors: Sun Hailu , Liu Aijun , Liu Lihong , Wang Wei , Cai Zhen , Yan Hua , Chen Lijuan , Gao Guangxun , Wang Fang , Liao Aijun , Chen Bing , Feng Jia , Li Juan , Huang Dong-Ping , Gao Da , Zhang Qi-Ke , Luo Jun , Fu Rong , Du Juan , Lu Jin 
Published: December 2022

Abstract
Background:Nonsecretory multiple myeloma (NSMM) is a rare type of multiple myeloma (MM). Few studies have described the clinical features and outcomes of NSMM in novel agents. Additionally, the prognostic characteristics have remained controversial in recent years.
Purpose: To investigate the clinical and prognostic features of NSMM and explore the prognostic value of involved free light chain (FLC) levels in NSMM patients in the Chinese population.
Methods:We retrospectively enrolled 176 newly diagnosed NSMM cases between January 2005 and December 2021 from 19 clinical centers in China. The control group was selected using a 1:4 propensity score matching technique of newly diagnosed secretory MM, with age, sex and diagnosis time as the matching variables.
Results: The median age of NSMM patients was 60 years, and 22.6% of patients were classified as ISS stage 3. The ORR of the NSMM patients was 87.4%, and the CR was 65.8%. Compared to the matched secretory MM patients, more NSMM patients achieved CR after first-line treatment (65.8% vs. 36%, p=0.000). TheORR of first-line treatment was not significantly different between NSMM and secretory MM (89.45% vs. 84.7%, p=0.196). The first-line PFS was 27.5 m and 23 m (p=0.063), and the median OS was 81 m and 70 months(p=0.401). However,for CR-achieved NSMM and CR-not-achieved NSMM patients, the median PFS was 37 mvs. 16 m(p=0.021), while the median OS showed no difference (107 m vs. 87 m, p=0.290). In multivariate analysis, the significant factors for PFS were age ≥65and ISS-3. ISS-3 was the only independent prognostic factor of OS. TheiFLC>50 mg/Lgroup had ahigh ORR of97.3%,and the median PFS and OS were 48 mand NR, respectively. Compared to the matched secretory MM, the iFLC ≥50 mg/Lgroup also showed more CR and longer OS (NR vs. 70 m, p=0.006) and PFS (48 m vs. 23 m, p=0.003).
Conclusions:Our results revealed that ChineseNSMM patients are younger and have a higher CR but not superior survival. The subgroup of NSMM patients with iFLC≥50 mg/L had better outcomes thansecretory MM.
Experimental investigation of coatings efficiency in micro-ball-end milling of pre-sintered 5Y-TZP ceramic
Authors: Marques Franck , Gilbin Alexandre , Fontaine Michaël , Escolle Bérenger , Picart Philippe 
Published: December 2022

Abstract

This study deals with micro-ball-end milling of a pre-sintered Yttria Tetragonal Zirconia Polycrystal. The aim is to underline the reliability of different coatings while machining this material regularly used in dental and luxury industries. A particular tool configuration – which is identified as critical by the targeted sectors – is tested previously determined stable cutting conditions, for all the chosen coatings. Cutting forces, tool reliability and surface integrity data is obtained by green machining of a 5Y-TZP (tetragonal zirconia polycrystal stabilized by 5%mol of yttrium) with 1 mm diameter tungsten carbide micro-tools coated with two PVD and one CVD coatings (respectively AlCrN, DLC and diamond). The results highlight that the choice of an appropriate coating is mandatory for this type of abrasive ceramics, even if they are partially sintered. Material flow, tool wear and machined surface quality are discussed and correlated.
Molecular regulation of differential lipid molecule accumulation in intramuscular fat and abdominal fat of chicken
Authors: Li Jingjing , Huang Qinke , Wu Jinbo , Li Ronghong , Chen Meiying , Ren Peng 
Published: December 2022

Abstract
Background
Reducing abdominal fat (AF) accumulation and increasing the level of intramuscular fat (IMF) simultaneously is a major breeding goal in poultry industry.
Results
To explore the different molecular mechanisms between AF and IMF, gene expression profiles in the breast muscle (BM) and AF among three chicken breeds were analyzed. A total of 4737 shared DEGs were identified between BM and AF, of which 2602 DEGs were upregulated and 2135 DEGs were downregulated in the BM groups compared with that in AF groups. DEGs involved in glycerophospholipid metabolism and glycerolipid metabolism were potential regulators resulting in the difference of lipid metabolite accumulation in IMF and AF. PPAR signaling pathway was the most important pathway involved in tissue-specific lipid deposition. Correlation analysis showed that most representative DEGs enriched in PPAR signaling pathway, such as FABP5, PPARG, ACOX1, GK2, were negatively correlated with PUFA-enriched glycerophospholipid molecules. Most DEGs related to glycerophospholipid metabolism, such as GPD2, GPD1, PEMT, CRLS1 and GBGT1, were positively correlated with glycerophospholipid molecules, especially DHA- and arachidonic acid (ARA)- containing glycerophospholipid molecules.
Conclusion
This study elucidated the molecular mechanism of tissue-specific lipid deposition and poultry meat quality.