bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting captive female giraffe stress response: Male presence, small enclosure, and low temperature
Authors: Saito Miho , Matsunaga Masayuki , Fukuizumi Hiroki , Nakamichi Masayuki , Kinoshita Kodzue 
Published: May 2023

AbstractTo improve animal welfare based on suitable social housing conditions, it is important to understand the factors that trigger high‐stress responses. Wild giraffes live in a fission–fusion society and males and females are rarely in the same herd for a long period. The captive condition of belonging to a herd with the same individuals for months or years is uncommon in nature. To understand the effect of male presence on female stress levels, fecal glucocorticoid metabolite (fGCM) levels and social interactions in two captive female giraffes were investigated. Additionally, the effect of enclosure size and temperature on fGCM level and social interactions were examined. The results showed no significant difference in the fGCM levels of females based on male presence. The frequency of agonistic behavior by the dominant female toward the subordinate female was significantly increased when a male was present. The subordinate female was significantly less likely to approach the dominant female and showed decreased affiliative and agonistic interactions toward the dominant female when a male was present. The frequencies of agonistic interactions between females were higher in the small enclosure regardless of male presence. Low temperature triggered higher fGCM levels and increased agonistic interaction in an aged female. The findings of this study suggest that these multiple factors should be considered individually to promote the welfare of captive giraffes.
On the correspondence between black holes, domain walls and fluxes
Authors: Cribiori Niccolò , Gnecchi Alessandra , Lüst Dieter , Scalisi Marco 
Published: May 2023

Abstract
We revisit and extend the correspondence between black holes, domain walls and fluxes in type IIA compactifications. We argue that these three systems can be described by the same supergravity effective action, modulo proper identifications and adjustments. Then, we apply the correspondence to investigate swampland conjectures on de Sitter and anti-de Sitter vacua, as well as on the black hole entropy. We show that, in certain cases, swampland conjectures can be motivated from properties of black hole solutions, such as positiveness of the entropy. This provides a bottom-up rationale which is complementary to the usual tests in string theory. When asking for an agreement between the anti-de Sitter and the black hole entropy distance conjectures, we are led to an extension of the correspondence which includes geometric fluxes and the associated Kaluza-Klein monopoles domain walls. Finally, we point out that the anti-de Sitter distance conjecture is naturally implemented in certain asymptotically anti-de Sitter black holes as a consequence of a constraint involving black hole charges and supergravity gauge couplings.
Notes on Ramond-Ramond spinors and bispinors in double field theory
Authors: Butter Daniel 
Published: May 2023

Abstract
The Ramond-Ramond sector of double field theory (DFT) can be described either as an O(D, D) spinor or an O(D − 1, 1) × O(1, D − 1) bispinor. Both formulations may be related to the standard polyform expansion in terms of even or odd rank field strengths corresponding to IIA or IIB duality frames. The spinor approach is natural in a (bosonic) metric formulation of DFT, while the bispinor is indispensable for supersymmetric DFT. In these notes, we show how these two approaches may be covariantly connected using a spinorial version of the DFT vielbein, which flattens an O(D, D) spinor into a bispinor. We also elaborate on details of the bispinor formulation in both even and odd D and elaborate on the distinction between the IIA/IIB/IIA*/IIB* duality frames.
Quantization of Jackiw-Teitelboim gravity with a massless scalar
Authors: Bak Dongsu , Kim Chanju , Yi Sang-Heon 
Published: May 2023

Abstract
We study canonical quantization of Jackiw-Teibelboim (JT) gravity coupled to a massless scalar field. We provide concrete expressions of matter SL(2, R) charges and the boundary matter operators in terms of the creation and annihilation operators in the scalar field. The matter charges are represented in the form of an oscillator (Jordon-Schwinger) realization of the SL(2, R) algebra. We also show how the gauge constraints are implemented classically, by matching explicitly classical solutions of Schwarzian dynamics with bulk solutions. We introduce n-point transition functions defined by insertions of boundary matter operators along the two-sided Lorentzian evolution, which may fully spell out the quantum dynamics in the presence of matter. For the Euclidean case, we proceed with a two-sided picture of the disk geometry and consider the two-sided 2-point correlation function where initial and final states are arranged by inserting matter operators in a specific way. For some simple initial states, we evaluate the correlation function perturbatively. We also discuss some basic features of the two-sided correlation functions with additional insertions of boundary matter operators along the two-sided evolution.
Bruhat intervals, subword complexes and brick polyhedra for finite Coxeter groups
Authors: Jahn Dennis , Stump Christian 
Published: May 2023

AbstractWe study the interplay between the discrete geometry of Bruhat poset intervals and subword complexes of finite Coxeter systems. We establish connections between the cones generated by cover labels for Bruhat intervals and of root configurations for subword complexes, culminating in the notion of brick polyhedra for general subword complexes.
Cognitive and visual task effects on gaze behaviour and gait of younger and older adults
Authors: Walsh Gregory S. , Snowball James 
Published: May 2023

AbstractCognitive dual tasks alter gait of younger and older adults and recent research has demonstrated that they also influence gaze behaviour and standing postural control. These findings suggest that age-related changes in cognitive and gaze function might increase fall risk in older adults. The purpose of this study was to determine the effect cognitive and visual dual tasks on the gait and gaze behaviour of younger and older adults. Ten older and ten younger adults walked for 3 min on a treadmill at preferred walking speed under three conditions, single task, cognitive and visual dual task conditions. Gait dynamics were measured using accelerometry and gaze behaviour was measured using wearable eye-trackers. Stride time variability and centre of mass (COM) motion complexity increased in dual-task conditions in older adults but had no difference for younger adults. Dual tasks had limited effect on gaze behaviour; however, visual input duration was greater, and visual input frequency and saccade frequency were lower in older than younger adults. The gaze adaptations in older adults may be the result of slower visual processing or represent a compensatory strategy to suppress postural movement. The increase in gait COM motion complexity in older adults suggests the dual tasks led to more automatic gait control resulting from both cognitive and visual tasks.
Radial HR-pQCT and Finite Element Analysis in HPP Patients are Superior in Identifying Susceptibility to Fracture-Associated Skeletal Affections Compared to DXA and Laboratory Tests
Authors: Schmidt Felix N. , Schmidt Constantin , Delsmann Julian , Amling Michael , Barvencik Florian 
Published: May 2023

AbstractHypophosphatasia (HPP) is an inborn disease that causes a rare form of osteomalacia, a mineralization disorder affecting mineralized tissues. Identification of patients at high risk for fractures or other skeletal manifestations (such as insufficiency fractures or excessive bone marrow edema) by bone densitometry and laboratory tests remains clinically challenging. Therefore, we examined two cohorts of patients with variants in the ALPL gene grouped by bone manifestations. These groups were compared by means of bone microarchitecture using high-resolution peripheral quantitative computed tomography (HR-pQCT) and simulated mechanical performance utilizing finite element analysis (FEA). Whereas the incidence of skeletal manifestations among the patients could not be determined by dual energy X-ray absorptiometry (DXA) or laboratory assessment, HR-pQCT evaluation showed a distinct pattern of HPP patients with such manifestations. Specifically, these patients had a pronounced loss of trabecular bone mineral density, increased trabecular spacing, and decreased ultimate force at the distal radius. Interestingly, the derived results indicate that the non-weight-bearing radius is superior to the weight-bearing tibia in identifying deteriorated skeletal patterns. Overall, the assessment by HR-pQCT appears to be of high clinical relevance due to the improved identification of HPP patients with an increased risk for fractures or other skeletal manifestations, especially at the distal radius.
A Metagenomic and Amplicon Sequencing Combined Approach Reveals the Best Primers to Study Marine Aerobic Anoxygenic Phototrophs
Authors: Gazulla Carlota R. , Cabello Ana María , Sánchez Pablo , Gasol Josep M. , Sánchez Olga , Ferrera Isabel 
Published: May 2023

AbstractStudies based on protein-coding genes are essential to describe the diversity within bacterial functional groups. In the case of aerobic anoxygenic phototrophic (AAP) bacteria, the pufM gene has been established as the genetic marker for this particular functional group, although available primers are known to have amplification biases. We review here the existing primers for pufM gene amplification, design new ones, and evaluate their phylogenetic coverage. We then use samples from contrasting marine environments to evaluate their performance. By comparing the taxonomic composition of communities retrieved with metagenomics and with different amplicon approaches, we show that the commonly used PCR primers are biased towards the Gammaproteobacteria phylum and some Alphaproteobacteria clades. The metagenomic approach, as well as the use of other combinations of the existing and newly designed primers, show that these groups are in fact less abundant than previously observed, and that a great proportion of pufM sequences are affiliated to uncultured representatives, particularly in the open ocean. Altogether, the framework developed here becomes a better alternative for future studies based on the pufM gene and, additionally, serves as a reference for primer evaluation of other functional genes.
Detection efficacy of [89Zr]Zr-PSMA-617 PET/CT in [68Ga]Ga-PSMA-11 PET/CT-negative biochemical recurrence of prostate cancer
Authors: Rosar Florian , Khreish Fadi , Marlowe Robert J. , Schaefer-Schuler Andrea , Burgard Caroline , Maus Stephan , Petto Sven , Bartholomä Mark , Ezziddin Samer 
Published: May 2023

Abstract
Rationale
In patients with biochemical recurrence of prostate cancer (BCR), preliminary data suggest that prostate-specific membrane antigen (PSMA) ligand radiotracers labeled with zirconium-89 (89Zr; half-life ~ 78.41 h), which allow imaging ≥ 24 h post-injection, detect suspicious lesions that are missed when using tracers incorporating short-lived radionuclides.

Materials and methods
To confirm [89Zr]Zr-PSMA-617 positron emission tomography/computed tomography (PET/CT) detection efficacy regarding such lesions, and compare quality of 1-h, 24-h, and 48-h [89Zr]Zr-PSMA-617 scans, we retrospectively analyzed visual findings and PET variables reflecting lesional [89Zr]Zr-PSMA-617 uptake and lesion-to-background ratio. The cohort comprised 23 men with BCR post-prostatectomy, median (minimum–maximum) prostate-specific antigen (PSA) 0.54 (0.11–2.50) ng/mL, and negative [68Ga]Ga-PSMA-11 scans 40 ± 28 d earlier. Primary endpoints were percentages of patients with, and classifications of, suspicious lesions.

Results
Altogether, 18/23 patients (78%) had 36 suspicious lesions (minimum–maximum per patient: 1–4) on both 24-h and 48-h scans (n = 33 lesions) or only 48-h scans (n = 3 lesions). Only one lesion appeared on a 1-h scan. Lesions putatively represented local recurrence in 11 cases, and nodal or bone metastasis in 21 or 4 cases, respectively; 1/1 lesion was histologically confirmed as a nodal metastasis. In all 15 patients given radiotherapy based on [89Zr]Zr-PSMA-617 PET/CT, PSA values decreased after this treatment. Comparison of PET variables in 24-h vs 48-h scans suggested no clear superiority of either regarding radiotracer uptake, but improved lesion-to-background ratio at 48 h.

Conclusions
In men with BCR and low PSA, [89Zr]Zr-PSMA-617 PET/CT seems effective in finding prostate malignancy not seen on [68Ga]Ga-PSMA-11 PET/CT. The higher detection rates and lesion-to-background ratios of 48-h scans versus 24-h scans suggest that imaging at the later time may be preferable. Prospective study of [89Zr]Zr-PSMA-617 PET/CT is warranted.
Evaluating Implementation Costs of an Enhanced Recovery After Surgery (ERAS) Protocol in Colorectal Surgery: A Systematic Review
Authors: Hong Minki , Ghajar Mina , Allen William , Jasti Shravya , Alvarez‐Downing Melissa M. 
Published: May 2023

AbstractBackgroundEnhanced recovery after surgery (ERAS) protocols have been well documented in the current literature to improve healthcare outcomes by decreasing length of stay, resource utilization, and morbidity without increasing readmission rates or complications. This subsequently leads to a net decrease in hospital costs. However, the initial costs of implementing such a program have not been well described, which is crucial information for hospitals with less resources. The aim of this study was to provide a cohesive review of the current literature for the costs of implementing a colorectal surgery ERAS protocol.MethodsA comprehensive review was conducted on five databases (Google Scholar, Web of Science, PROSPERO, PubMed, and Cochrane) with the assistance of a professional librarian. All relevant English articles published between 1995 and June 2021 were screened for eligibility prior to inclusion in the review. Cost data were converted to US dollars based on the exchange rate at the end time of the study period for standardization.ResultsSeven studies were included for review. The studies evaluated a range of 50–1295 patients through their respective ERAS programs, which were followed for 5 to 22 months. ERAS implementation costs ranged from $57 to $1536 per patient. Components for each ERAS program varied for each study, but ultimately, the greatest costs were attributed to personnel.ConclusionsDespite data heterogeneity and inconsistencies between cost breakdowns, a majority of the implementation cost was found to be secondary to personnel. This review demonstrates the need for a more standardized approach for reporting ERAS implementation costs through an open database as well as a potential streamlining of the ERAS protocol to facilitate implementation in institutions with less financial resources.
Investigation on potential and limitations of ERA5 Reanalysis downscaled on Italy by a convection-permitting model
Authors: Adinolfi Marianna , Raffa Mario , Reder Alfredo , Mercogliano Paola 
Published: May 2023

AbstractThis study presents a comprehensive assessment of a dynamical downscaling of ERA5 Reanalysis recently performed over Italy through the COSMO-CLM model at a convection-permitting scale (0.02°) over the period 1989–2020. Results are analysed against several independent observational datasets and reanalysis products. The capability of the downscaling to realistically represent the climatology for 2 m temperature and precipitation is analysed over the whole peninsula and subdomains. Hourly precipitation patterns, orography effects, and urban climate dynamics are also investigated, highlighting the weaknesses and strengths of the convection-permitting model. In particular, gains in performances are achieved in mountainous areas where the climate characteristics are correctly represented, as are the hourly precipitation characteristics. Losses in performances occur in coastal and flat areas of the Italian peninsula, where the convection-permitting model performance does not seem to be satisfactory, as opposed to complex orographic areas. The adopted urban parameterisation is demonstrated to simulate heat detection for two Italian cities: Rome and Milan. Finally, a subset of extreme climate indicators is evaluated, finding: (i) a region-dependent response, (ii) a notable performance of the convection-permitting model over mountainous areas and (iii) discrepancies in the South, Central and Insular subdomains. Climate indicators detect extreme events at a detailed scale, becoming an important tool for turning climate data into information.
Rates of clinical remission and inadequate response to advanced therapies among patients with ulcerative colitis in Germany
Authors: Bokemeyer Bernd , Picker Nils , Kromer Daniel , Rosin Ludger , Patel Haridarshan 
Published: May 2023

Abstract
Purpose
Many patients treated for ulcerative colitis (UC) do not achieve clinical remission. This real-world study assessed clinical remission and inadequate response rates among patients with UC in Germany treated with advanced therapies.

Methods
This retrospective chart review included patients with UC newly initiating advanced (index) therapy (anti-TNFα agents, vedolizumab, tofacitinib) from January 2017–September 2019 (index date). Included patients had data for ≥ 12 months before (baseline period) and after the index date (follow-up period). Remission was defined as a partial Mayo score ≤ 1. Indicators of inadequate response were: index therapy discontinuation; therapy adjustments (index therapy dose escalation; augmentation with non-advanced therapies; corticosteroid [CS] use during maintenance therapy); CS dependency (use for ≥ 12 weeks); and UC-related hospitalisation, surgery or emergency department visit. Time to first remission and inadequate response were analyzed using Kaplan–Meier analyses.

Results
Among 149 patients with UC (median age: 40 years), 96 (64.4%) were biologic-naïve and 42 (28.2%) received CS at the index date. Within 12 months, 52 patients (47.2%) were in remission; of these, 13 patients (25.0%) received ≥ 1 therapy adjustment. At 12 months, 55 patients (37.6%) had ≥ 1 indicator of an inadequate response. Median time to remission was longer among biologic-experienced vs biologic-naïve patients (24 vs 7 months; p = 0.012).

Conclusion
Over half of the patients were not in clinical remission after 12 months and more than one-third experienced inadequate response. One-quarter of patients in remission required therapy adjustments. Patients with UC require therapies that are more effective than those currently available to achieve better treatment outcomes.
Hippocampal neurogenesis and Arc expression are enhanced in high-fat fed prepubertal female pigs by a diet including omega-3 fatty acids and Bifidobacterium breve CECT8242
Authors: Huguet Gemma , Puig-Parnau Irene , Serrano Jose C. E. , Martin-Gari Meritxell , Rodríguez-Palmero María , Moreno-Muñoz Jose Antonio , Tibau Joan , Kádár Elisabet 
Published: May 2023

Abstract
Purpose
Obesity during childhood has become a pandemic disease, mainly caused by a diet rich in sugars and fatty acids. Among other negative effects, these diets can induce cognitive impairment and reduce neuroplasticity. It is well known that omega-3 and probiotics have a beneficial impact on health and cognition, and we have hypothesized that a diet enriched with Bifidobacterium breve and omega-3 could potentiate neuroplasticity in prepubertal pigs on a high-fat diet.

Methods
Young female piglets were fed during 10 weeks with: standard diet (T1), high-fat (HF) diet (T2), HF diet including B. breve CECT8242 (T3) and HF diet including the probiotic and omega-3 fatty acids (T4). Using hippocampal sections, we analyzed by immunocytochemistry the levels of doublecortin (DCX) to study neurogenesis, and activity-regulated cytoskeleton-associated protein (Arc) as a synaptic plasticity related protein.

Results
No effect of T2 or T3 was observed, whereas T4 increased both DCX+ cells and Arc expression. Therefore, a diet enriched with supplements of B. breve and omega-3 increases neurogenesis and synaptic plasticity in prepubertal females on a HF diet from nine weeks of age to sexual maturity. Furthermore, the analysis of serum cholesterol and HDL indicate that neurogenesis was related to lipidic demand in piglets fed with control or HF diets, but the neurogenic effect induced by the T4 diet was exerted by mechanisms independent of this lipidic demand.

Conclusion
Our results show that the T4 dietary treatment is effective in potentiating neural plasticity in the dorsal hippocampus of prepubertal females on a HF diet.
Knife wound or nosebleed—where does the blood at the crime scene come from?
Authors: Konrad Helen , Lawniczek Janina , Bajramjan Christine , Weber Lisa , Bajanowski Thomas , Poetsch Micaela 
Published: May 2023

AbstractSecretion analysis is a useful tool in forensic genetics, since it establishes the (cellular) origin of the DNA prior in addition to the identification of the DNA donor. This information can be crucial for the construction of the crime sequence or verification of statements of people involved in the crime. For some secretions, rapid/pretests already exist (blood, semen, urine, and saliva) or can be determined via published methylation analyses or expression analyses (blood, saliva vaginal secretions, menstrual blood, and semen). To discriminate nasal secretion/blood from other secretions (like oral mucosa/saliva, blood, vaginal secretion, menstrual blood, and seminal fluid), assays based on specific methylation patterns at several CpGs were set up in this study. Out of an initial 54 different CpG markers tested, two markers showed a specific methylation value for nasal samples: N21 and N27 with a methylation mean value of 64.4% ± 17.6% and 33.2% ± 8.7%, respectively. Although identification or discrimination was not possible for all nasal samples (due to partial overlap in methylation values to other secretions), 63% and 26% of the nasal samples could be unambiguously identified and distinguished from the other secretions using the CpG marker N21 and N27, respectively. In combination with a blood pretest/rapid test, a third marker (N10) was able to detect nasal cells in 53% of samples. Moreover, the employment of this pretest increases the proportion of identifiable or discriminable nasal secretion samples using marker N27 to 68%. In summary, our CpG assays proved to be promising tools in forensic analysis for the detection of nasal cells in samples from a crime scene.
Computing Longest Lyndon Subsequences and Longest Common Lyndon Subsequences
Authors: Bannai Hideo , I. Tomohiro , Kociumaka Tomasz , Köppl Dominik , Puglisi Simon J. 
Published: May 2023

AbstractGiven a string T of length n whose characters are drawn from an ordered alphabet of size $$\sigma $$
σ
, its longest Lyndon subsequence is a maximum-length subsequence of T that is a Lyndon word. We propose algorithms for finding such a subsequence in $$\mathop {}\mathopen {}\mathcal {O}\mathopen {}(n^3)$$

O

(

n
3

)

time with $$\mathop {}\mathopen {}\mathcal {O}\mathopen {}(n)$$

O

(
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)

space, or online in $$\mathop {}\mathopen {}\mathcal {O}\mathopen {}(n^3)$$

O

(

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space and time. Our first result can be extended to find the longest common Lyndon subsequence of two strings of length at most n in $$\mathop {}\mathopen {}\mathcal {O}\mathopen {}(n^4 \sigma )$$

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(

n
4

σ
)

time using $$\mathop {}\mathopen {}\mathcal {O}\mathopen {}(n^2)$$

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(

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space.