bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional printing in modelling mitral valve interventions
Authors: Bharucha Apurva H. , Moore John , Carnahan Patrick , MacCarthy Philip , Monaghan Mark J. , Baghai Max , Deshpande Ranjit , Byrne Jonathan , Dworakowski Rafal , Eskandari Mehdi 
Published: August 2023

AbstractMitral interventions remain technically challenging owing to the anatomical complexity and heterogeneity of mitral pathologies. As such, multi-disciplinary pre-procedural planning assisted by advanced cardiac imaging is pivotal to successful outcomes. Modern imaging techniques offer accurate 3D renderings of cardiac anatomy; however, users are required to derive a spatial understanding of complex mitral pathologies from a 2D projection thus generating an ‘imaging gap’ which limits procedural planning. Physical mitral modelling using 3D printing has the potential to bridge this gap and is increasingly being employed in conjunction with other transformative technologies to assess feasibility of intervention, direct prosthesis choice and avoid complications. Such platforms have also shown value in training and patient education. Despite important limitations, the pace of innovation and synergistic integration with other technologies is likely to ensure that 3D printing assumes a central role in the journey towards delivering personalised care for patients undergoing mitral valve interventions.
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents
Authors: Wahyuni Tutik Sri , Sukma Nida S. , Permanasari Adita A. , Aoki-Utsubo Chie , Widyawaruyanti Aty , Hafid Achmad Fuad 
Published: August 2023

Background: Medicinal plants have been demonstrated to possess various pharmacological effects including anti-hepatitis C virus. Acacia mangium is one of the Acacia genus that contain various metabolites. The metaboilites play an important role for antiviral activities. The current study examined the anti-hepatitis C virus (HCV) activities of Acacia mangium extracts in solvents with various polarities and further evaluated the mechanism of action of the extracts on the protein virus and combination treatment models. Methods: Anti-hepatitis C virus activities was conducted with in vitro cells culture of Huh 7it both in a single or combination treatment. Its NS3 protein inhibition was evaluated with western blotting assay. Results: The results revealed the strong anti-HCV activities of the extracts. The 50% inhibition concentrations (IC50s) of the ethanol, n-hexane, dichloromethane and methanol extracts were of 4.6 ± 0.3, 2.9 ± 0.2, 0.2 ± 0.3, and 2.8 ± 0.2 μg/mL, respectively, and no cytotoxic effect was detected. These extracts displayed stronger effects than the positive control ribavirin. The mode of action of the ethanol extract was evaluated at 30 µg/mL, revealing that the inhibitory effect was stronger on the post-entry step than on the entry step. Western blotting revealed that the extracts decreased NS3 protein expression, indicating that virus replication was suppressed. Further evaluation illustrated that combined treatment with the ethanol extract enhanced the anti-viral activity of simeprevir. Conclusions: These results indicated that A. mangium leaves could represent sources of anti-HCV agents.
Can yoga show better vascular outcomes than regular exercise among office workers: a scoping review
Authors: Pattamukkil Neha Susan Jibi , Shruthi Poovitha P , Kadavigere Rajagopal , K Vaishali , K N Shivashankar , Sukumar Suresh , Ravichandran Sneha , Kamath Koustubh 
Published: August 2023

Background: Isolated systolic hypertension (ISH) in the elderly is mostly brought on by arterial stiffness with ageing, which results in a lack of vascular compliance. The main cardiovascular (CV) hazards for elderly persons are arterial ageing and high blood pressure (BP). The aim of this study was to investigate if endothelial function in young, middle-aged, and older, healthy persons would be improved by Bikram yoga, a heated form of hatha yoga. Methods: Randomised control trials on yoga, vascular function, exercise, and office employees were used in the study, which was done in four databases (Scopus, PubMed, Ovid, and Science Direct). Results: 3 of 103 articles were included. We identified improvement of vascular function, FMD and arterial stiffness using yoga intervention. While exercise does not significantly affect ventricular function, yoga significantly reduces heart rate (p = 0.031) and increases pulse pressure (PD). Yoga also results in a mean increase in left ventricular ejection time (LVET), which was observed in the yoga group. The improvement in myocardial function was more pronounced in the yoga group than in the exercise group, according to the between-group analysis, which revealed a significant difference in post-intervention rate-pressure product (RPP) between the yoga and exercise groups. With a P value of 0.004, the mean% Mean Arterial Pressure (MAP) was significantly lower, demonstrating that yoga was effective in lowering MAP. However, older adults, but not younger ones, experienced a significant increase in brachial artery FMD (Flow Mediated Dilation) following the intervention. Conclusions: Yoga interventions may improve vascular function, arterial stiffness, flow-mediated dilation, heart rate, RRP and MAP, with older adults experiencing a significant increase in brachial artery FMD, suggesting the effectiveness of yoga in improving myocardial function and lowering MAP, particularly in older adults.
Tight and Compact Sample Average Approximation for Joint Chance-Constrained Problems with Applications to Optimal Power Flow
Authors: Porras Álvaro , Domínguez Concepción , Morales Juan Miguel , Pineda Salvador 
Published: August 2023

In this paper, we tackle the resolution of chance-constrained problems reformulated via sample average approximation. The resulting data-driven deterministic reformulation takes the form of a large-scale mixed-integer program (MIP) cursed with Big-Ms. We introduce an exact resolution method for the MIP that combines the addition of a set of valid inequalities to tighten the linear relaxation bound with coefficient strengthening and constraint screening algorithms to improve its Big-Ms and considerably reduce its size. The proposed valid inequalities are based on the notion of k-envelopes and can be computed off-line using polynomial-time algorithms and added to the MIP program all at once. Furthermore, they are equally useful to boost the strengthening of the Big-Ms and the screening rate of superfluous constraints. We apply our procedures to a probabilistically constrained version of the DC optimal power flow problem with uncertain demand. The chance constraint requires that the probability of violating any of the power system’s constraints be lower than some positive threshold. In a series of numerical experiments that involve five power systems of different size, we show the efficiency of the proposed methodology and compare it with some of the best performing convex inner approximations currently available in the literature. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms – Discrete. Funding: This work was supported in part by the European Research Council under the EU Horizon 2020 research and innovation program [Grant 755705], in part by the Spanish Ministry of Science and Innovation [Grant AEI/10.13039/501100011033] through project PID2020-115460GB-I00, and in part by the Junta de Andalucía and the European Regional Development Fund through the research project P20_00153. Á. Porras is also financially supported by the Spanish Ministry of Science, Innovation and Universities through the University Teacher Training Program with fellowship number FPU19/03053. Supplemental Material: The online supplement is available at https://doi.org/10.1287/ijoc.2022.0302 .
Counterparty Risk and Counterparty Choice in the Credit Default Swap Market
Authors: Du Wenxin , Gadgil Salil , Gordy Michael B. , Vega Clara 
Published: August 2023

We investigate how market participants price and manage counterparty credit risk using confidential trade repository data on single-name credit default swap (CDS) transactions. We find that counterparty risk has a modest impact on the pricing of CDS contracts but a large impact on the choice of counterparties. For contracts ineligible for central clearing, we show that market participants are significantly less likely to trade with counterparties whose credit risk is highly correlated with the credit risk of the reference entities and with counterparties whose credit quality is low. For clearable contracts, we find that nondealers are more likely to clear during a crisis and less likely to clear when the reference entity is a large U.S. dealer or a sovereign. This paper was accepted by Kay Giesecke, finance. Supplemental Material: The internet appendix and data are available at https://doi.org/10.1287/mnsc.2023.4870 .
Does Social Media Dominate Government Report Cards in Influencing Nursing Home Demand?
Authors: Li Yuanchen , Lu Lauren Xiaoyuan , Lu Susan Feng 
Published: August 2023

Problem definition: Social media has become an indispensable platform for disseminating quality information to consumers across various service sectors. Recently, it has extended its influence to healthcare services, which traditionally relied on government report cards to disclose standardized quality information to the public. This article explores the impact of social media on consumer demand for healthcare services and compares its effectiveness with government report cards. Methodology/results: We analyze quality ratings of U.S. nursing homes collected from two information channels: (1) consumer ratings on Yelp and (2) government ratings on Nursing Home Compare, both of which adopt a five-star quality rating scale and are accessible on the Internet. We employ the method of difference-in-differences with continuous treatment intensity and instrumental variables to analyze the data. Using nursing home resident admissions as a proxy for consumer demand, we find that higher Yelp ratings led to higher consumer demand, particularly among Medicare-covered consumers. Furthermore, the effect of Yelp ratings was primarily driven by extreme ratings (one-star or five-star), as opposed to neutral ratings. We also find that Yelp ratings exerted a stronger effect on consumer demand than government ratings. This dominance of Yelp ratings over government ratings was observed primarily in markets with high Yelp penetration or markets with low and medium consumer education levels. Although higher Yelp ratings were associated with increased net incomes, we find little evidence that nursing homes made quality improvement in response to their Yelp ratings. Managerial implications: We recommend that the Centers for Medicare and Medicaid Services recognize social media platforms as valuable sources of information and collaborate with reputable platforms, such as Yelp, to promote public awareness of government report cards like Nursing Home Compare. Moreover, we advise nursing home operators to proactively manage their reputation on social media by promptly addressing consumer complaints and implementing quality improvement measures. Funding: Y. Li was supported by the National Natural Science Foundation of China [Grant 72301193], the Shanghai Sailing Program [Grant 22YF1451000], and the Fundamental Research Funds for the Central Universities. S. F. Lu was supported by the Gerald Lyles Rising Star fund. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2021.0303 .
Effects of low versus high inspired oxygen fraction on myocardial injury after transcatheter aortic valve implantation: A randomized clinical trial
Authors: Cho Youn Joung , Hyeon Cheun , Nam Karam , Lee Seohee , Ju Jae-Woo , Kang Jeehoon , Han Jung-Kyu , Kim Hyo-Soo , Jeon Yunseok 
Published: August 2023

Background
Oxygen therapy is used in various clinical situation, but its clinical outcomes are inconsistent. The relationship between the fraction of inspired oxygen (FIO2) during transcatheter aortic valve implantation (TAVI) and clinical outcomes has not been well studied. We investigated the association of FIO2 (low vs. high) and myocardial injury in patients undergoing TAVI.

Methods
Adults undergoing transfemoral TAVI under general anesthesia were randomly assigned to receive FIO2 0.3 or 0.8 during procedure. The primary outcome was the area under the curve (AUC) for high-sensitivity cardiac troponin I (hs-cTnI) during the first 72 h following TAVI. Secondary outcomes included the AUC for postprocedural creatine kinase-myocardial band (CK-MB), acute kidney injury and recovery, conduction abnormalities, pacemaker implantation, stroke, myocardial infarction, and in-hospital mortality.

Results
Between October 2017 and April 2022, 72 patients were randomized and 62 were included in the final analysis (n = 31 per group). The median (IQR) AUC for hs-cTnI in the first 72 h was 42.66 (24.82–65.44) and 71.96 (35.38–116.34) h·ng/mL in the FIO2 0.3 and 0.8 groups, respectively (p = 0.066). The AUC for CK-MB in the first 72 h was 257.6 (155.6–322.0) and 342.2 (195.4–485.2) h·ng/mL in the FIO2 0.3 and 0.8 groups, respectively (p = 0.132). Acute kidney recovery, defined as an increase in the estimated glomerular filtration rate ≥ 25% of baseline in 48 h, was more common in the FIO2 0.3 group (65% vs. 39%, p = 0.042). Other clinical outcomes were comparable between the groups.

Conclusions
The FIO2 level did not have a significant effect on periprocedural myocardial injury following TAVI. However, considering the marginal results, a benefit of low FIO2 during TAVI could not be ruled out.
Magnitude and determinants of improved household latrine utilization in Ethiopia: Multilevel analysis of the mini Ethiopian Demographic Health Survey (EDHS) 2019
Authors: Tesfaw Aragaw , Tiruneh Mulu , Mamuye Melkalem , Walle Zebader , Teshager Wondossen , Teshome Fentaw , Taye Alebachew , Dessalegn Wondimnew , Walle Gashaw , Gebeyehu Asaye Alemneh 
Published: August 2023

Introduction
Lack of sanitation is a major global problem mainly for the poor and disadvantaged. According to the 2016 Ethiopian Demographic and Health Surveys (EDHS) report, one out of every three households lack a toilet in Ethiopia and about 56% of rural households use unimproved toilet facilities. We aimed to determine the magnitude of improved household latrine utilization and its determinants in Ethiopia using the mini–Ethiopian Demographic Health Survey (EDHS) 2019 data set.

Method
A secondary data analysis was conducted based on the mini 2019 EDHS data set. A total weighted sample of 8663 households were involved in analysis. After selecting the relevant variables for the outcome variable, we have fitted four different models. The null (empty) model with no independent variables and the second model contained the effects of the individual-level factors on the outcome variable. The third model included the influence of the community-level factors on the response variable, and the final multilevel multivariable logistic regression model examined the effects of individual-level and community-level variables on the outcome variable. The measure of variation was quantified using Intra-Class Correlation (ICC), Median Odds Ratio, and Proportional Change in Variance (PCV). The Adjusted Odds Ratio (AOR) with a 95% Confidence Interval (CI) was used to show the strength of association and statistical significance was declared at p value < 0.05.

Results
The magnitude of improved latrine utilization in Ethiopia was 19.5% with 95% CI (18.6%, 20.3%). The factors: educational status (AOR = 1.67; 95% CI: (1.10, 2.55), highest wealth index (AOR = 3.73; 95% CI: (2.73, 5.12), urban residence (AOR = 3.09; 95% CI: (1.68, 5.67), living in Addis Ababa (AOR = 4.08; 95% CI: (1.03, 16.2) and Dire Dawa (AOR = 8.22; 95% CI: (2.46, 27.42) and Somali regions (AOR = 3.11; 95% CI: (1.15, 8.42) were significantly associated to improved latrine utilization in Ethiopia.

Conclusion
The magnitude of improved latrine utilization was quite low in Ethiopia. Higher wealth index, living in more urbanized areas, and the household head’s educational status were all significant predictors of improved latrine utilization. The finding implies a need to increase household’s access to latrine facilities and improve latrine utilization, particularly for rural households in the country.
Clopidogrel-Induced Eosinophilic Colitis
Authors: Djahandideh Sheijani Shirin , Calabrese Francesco , Pasta Andrea , Marabotto Elisa , Bodini Giorgia , Furnari Manuele , Grillo Federica , Mastracci Luca , Savarino Edoardo V. , Savarino Vincenzo , Giannini Edoardo G. 
Published: August 2023

ABSTRACT
Eosinophilic colitis is a rare condition characterized by histologic findings of high eosinophilic infiltrate in the gut wall, typically presenting with diarrhea and abdominal pain. The etiology of this entity remains unclear because it can be primary or can occur secondarily to infections, drugs, or even in association with immune-mediated diseases. We present the case of a woman referred to our outpatient clinic for chronic diarrhea that had been worsening for months. Colonoscopy with biopsies was performed, and eosinophilic colitis associated with the use of clopidogrel was diagnosed. After clopidogrel discontinuation, a complete remission of the clinical and histological picture was observed.
Penyelesaian Sengketa Tanah Harta Pusako Tinggi Terhadap Ahli Waris Yang Punah Melalui Niniak Mamak Nan Salapan Di Nagari Ampalu Kabupaten Lima Puluh Kota
Authors: Sonanda Rahmi , Syuriani Syuriani , Nazar Jazman 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui bagaimana penyelesaian sengketa tanah harta pusako tinggi terhadap ahli waris yang punah melalui Niniak Mamak Nan Salapan di Nagari Ampalu, Kabupaten Lima Puluh Kota. Di Minangkabau sebenarnya tidak dikenal adanya ahli waris yang punah terhadap harta peninggalan, akan tetapi punah yang dimaksud disini adalah ketika keturunan pokok atau inti dari suatu kaum itu sudah tiada dan harta peninggalan yang ada akan diwariskan kepada kaum lainnya yang berhak atas harta warisan tersebut. Penelitian ini bersifat deskriptif dengan jenis penelitian hukum Yuridis Empiris. Penulis melakukan penelitian secara sosiologis, secara lapangan dimana kita akan mengkaji ketentuan hukum tentang penyelesaian sengketa tanah harta pusako tinggi jika penerus pokoknya sudah tidak ada secara lansung didalam kehidupan masyarakat Minangkabau di Jorong Mangunai Tinggi, Kenagarian Ampalu. Hasil penelitian berupa cara penyelesaian persengketaan masyarakat hukum di Jorong Mangunai Tinggi menggunakan peraturan adatnya yang mengutamakan musyawarah sehingga menghasilkan keputusan yang sesuai dengan peraturan adat diwilayah hukum adat Jorong Mangunai Tinggi. Sesuai dengan fakta lapangan yang didapat penulis, peran lembaga Ninak Mamak Nan Salapan merupakan bagian dari KAN dan hasil keputusan yang dikeluarkan oleh lembaga Niniak Mamak Nan Salapan diserahkan kepada KAN melalui proses regulasi sehingga keputusan tersebut dianggap sesuai dengan peraturan perundang-undangan yang ada.
A guide to conducting systematic reviews of clinical laboratory tests
Authors: Don-Wauchope Andrew C. , Rodriguez-Capote Karina , Assaad Ramy Samir , Bhargava Seema , Zemlin Annalise E. 
Published: August 2023

Abstract
Clinical laboratory professionals have an instrumental role in supporting clinical decision making with the optimal use of laboratory testing for screening, risk stratification, diagnostic, prognostic, treatment selection and monitoring of different states of health and disease. Delivering evidence-based laboratory medicine relies on review of available data and literature. The information derived, supports many national policies to improve patient care through clinical practice guidelines or best practice recommendations. The quality, validity and bias of this literature is variable. Hence, there is a need to collate similar studies and data and analyse them critically. Systematic review, thus, becomes the most important source of evidence. A systematic review, unlike a scoping or narrative review, involves a thorough understanding of the procedure involved and a stepwise methodology. There are nuances that need some consideration for laboratory medicine systematic reviews. The purpose of this article is to describe the process of performing a systematic review in the field of laboratory medicine, describing the available methodologies, tools and software packages that can be used to facilitate this process.
The Partisan Dimensions of Earmarking in the U.S. House of Representatives
Authors: Fagan Edward J. , Theriault Sean M. , Whittington Ryan 
Published: August 2023

Abstract
Passing out federal dollars to specific projects in particular districts had been a popular way for congressional leaders to build large bipartisan majorities for major bills since the very first meeting of Congress. By matching projects to districts, scholars have been able to systematically analyze which members were successful in getting their project funded. But for one year, though, the requests members submitted were never known. Using earmark requests data during the 111th Congress, we can know both the requests and the awards. Knowing the former changes our understanding of the latter. We find that the request process is largely driven by ideology, rather than electoral vulnerability. More moderate Republicans tended to seek more earmarks than their more conservative copartisans; some of whom completely opted out of the process. The effect was the opposite for Democrats, whose moderates requested fewer earmarks. When these requests are taken into consideration, the awarding process appears to be even less partisan than the raw data would suggest, confirming the bipartisan nature of the earmarking process.
The assessment of fetal cardiac functions in pregnancies with autoimmune diseases: a prospective case-control study
Authors: Yildirim Muradiye , Oluklu Deniz , Beser Dilek Menekse , Hendem Derya Uyan , Aktas Betul Akgun , Yildiz Esra Gulen , Kara Ozgur , Sahin Dilek 
Published: August 2023

Abstract

Objectives
This study aimed to assess the effect of the inflammatory process on fetal cardiac functions in pregnant women with autoimmune diseases (AID).

Methods
This prospective study included 36 pregnant women with diagnosed AID. Nineteen systemic lupus erythematosus, 12 antiphospholipid syndrome, 5 Sjögren’s syndrome, and 72 healthy pregnancies were included. Fetal cardiac functions were evaluated with pulsed-wave, tissue Doppler, and M-mode echocardiography.

Results
Sociodemographic data were similar in both groups. Significant increases were found in tricuspid E (43.5 ± 0.9, p<0.001) and A (59.2 ± 2.2, p<0.001) and E/A (0.74 ± 0.03, p<0.001), E’/A’ (0.64 ± 0.15, p<0.001), E/E’ (6.5 ± 0.6, p<0.001), and left ventricular myocardial performance index (0.54 ± 0.03, p=0.005). We demonstrated a significant decrease in tricuspid E’ (6.7 ± 0.6, p<0.001) and S’ (6.9 ± 1, p<0.001) and in TAPSE (7.7 ± 0.5, p=0.002). We also found a significantly prolonged PR interval (130 ± 8, p<0.001). There was a significant increase in E’ (6.8, p=0.033) and a significant decrease in E/E′ ratio (6.4, p=0.027) in the group using hydroxychloroquine (HCQ) compared to non-users.

Conclusions
We found that pregnancy with autoimmune diseases affects fetal heart functions. Additionally, hydroxychloroquine may positively affect the heart of AID fetuses. This information might be useful to clinicians in the follow-up of cardiovascular diseases.