bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between endothelin-1 and systemic lupus erythematosus: insights from a case–control study
Authors: Li Rong , Yang Chan , Tang Yang-Yang , Wang Da-Cheng , Xu Wang-Dong , Huang An-Fang 
Published: September 2023

AbstractSystemic lupus erythematosus (SLE) is a chronic rheumatic disorder. Endothelin-1, a vasoconstrictor, belongs to the endothelin family and is associated with vascular-related damages. To date, association between ET-1 and pathogenesis of SLE remains unclear. This case–control study was carried out by 314 SLE, 252 non-SLE diseases patients and 500 healthy controls. Serum ET-1, CCN3, IL-28B levels were detected by ELISA, and ET-1 gene polymorphisms (rs5369, rs5370, rs1476046, rs2070699, rs2071942, rs2071943, rs3087459, rs4145451, rs6458155, rs9369217) were genotyped with Kompetitive Allele-Specific PCR. SLE patients had high levels of ET-1, which were correlated with some clinical, laboratory features. Serum CCN3, IL-28B levels were higher in SLE patients, and ET-1 levels were positively correlated with the two cytokines. Rs5370, rs1476046, rs2070699, rs2071942, rs2071943, rs3087459, rs6458155 and rs2070699 were associated with SLE risk. Rs2070699 (T, TT) was related to SLE patients with alopecia. Rs5370 (T, TT, TG), rs1476046 (G,GA), rs2071942 (G,GA) and rs2071943 (G,GA) were associated with SLE patients with pericarditis, pyuria and fever manifestation, respectively. Rs3087459 (CC) and rs9369217 (TC) were related to SLE patients with positive anti-SSB antibody. Rs5369 (AA) was associated with IgG and CRP levels in SLE patients. In conclusion, elevated serum ET-1 in SLE patients may be a potential disease marker, and its gene polymorphisms were related to SLE susceptibility.
New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
Authors: Cros Maria Pol , Mir-Pedrol Júlia , Toloza Lorena , Knödlseder Nastassia , Maruotti Julien , Zouboulis Christos C. , Güell Marc , Fábrega Maria-José 
Published: September 2023

AbstractCutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes have been linked to healthy skin. In this scenario, bacterial extracellular vesicles (EVs) play a role in the interkingdom communication with the human host. The purpose of this study was to examine the impact of EVs generated by various phylotypes of C. acnes on inflammation and sebum production using different in vitro skin cell types. The main findings of this study reveal that the proteomic profile of the cargo embodied in the EVs reflects distinct characteristics of the different C. acnes phylotypes in terms of life cycle, survival, and virulence. The in vitro skin cell types showed an extended pro-inflammatory modulation of SLST A1 EVs consistently triggering the activation of the inflammation-related factors IL-8, IL-6, TNFα and GM-CSF, in comparison to SLST H1 and SLST H2. Additionally, an acne-prone skin model utilizing PCi-SEB and arachidonic acid as a sebum inducer, was employed to investigate the impact of C. acnes EVs on sebum regulation. Our findings indicated that all three types of EVs significantly inhibited sebum production after a 24-h treatment period, with SLST H1 EVs exhibiting the most pronounced inhibitory effect when compared to the positive control. The results of this study highlight the protective nature of C. acnes SLST H1 EVs and their potential use as a natural treatment option for alleviating symptoms associated with inflammation and oily skin.
Dynamic gravitational excitation of structural resonances in the hertz regime using two rotating bars
Authors: Tobias Brack , Jonas Fankhauser , Bernhard Zybach , Fadoua Balabdaoui , Stephan Kaufmann , Francesco Palmegiano , Jean-Claude Tomasina , Stefan Blunier , Donat Scheiwiller , Jürg Dual 
Published: September 2023

AbstractWith the planning of new ambitious gravitational wave observatories, fully controlled laboratory experiments on dynamic gravitation become more and more important. Such experiments can provide new insights in potential dynamic effects such as gravitational shielding or energy flow and might contribute to bringing light into the mystery still surrounding gravity. Here we present a laboratory-based transmitter-detector experiment using two rotating bars as transmitter and a 42 Hz, high-Q bending beam resonator as detector. Using a precise phase control to synchronize the rotating bars, a dynamic gravitational field emerges that excites the bending motion with amplitudes up to 100 nm/s or 370 pm, which is a factor of 500 above the thermal noise. The two-bar design enables the investigation of different transmitter configurations. The detector movement is measured optically, using three commercial interferometers. Acoustical, mechanical, and electrical isolation, a temperature-stable environment, and lock-in detection are central elements of the setup. The moving load response of the detector is numerically calculated based on Newton’s law of gravitation via discrete volume integration, showing excellent agreement between measurement and theory both in amplitude and phase. The near field gravitational energy transfer is 1025 times larger than the one of the propagating gravitational wave component.
ortho O-Annulated azabenzannulated perylenediimide and bisazacoronenediimide
Authors: David Arthur H. G. , Shymon Daryna , Melville Hayley , Accou Lou-Ann , Gapin Adèle , Allain Magali , Alévêque Olivier , Force Maximilien , Grosjean Alexis , Hudhomme Piétrick , Le Bras Laura , Goujon Antoine 
Published: September 2023

The synthesis of electron-deficient ortho O-annulated bisazacoronenediimides is reported. Their preliminary results in devices, strong light absorption and flat structure make them a new interesting scaffold for the design of electron acceptors.
Colchicine protects against the development of experimental abdominal aortic aneurysm
Authors: Zhao Yi , Shen Qi-Rui , Chen Yu-Xin , Shi Yu , Wu Wen-Bing , Li Qiao , Li Dong-Jie , Shen Fu-Ming , Fu Hui 
Published: September 2023

Abstract
Abdominal aortic aneurysm (AAA) is characterized by at least 1.5-fold enlargement of the infrarenal aorta, a ruptured AAA is life-threatening. Colchicine is a medicine used to treat gout and familial Mediterranean fever, and recently, it was approved to reduce the risk of cardiovascular events in adult patients with established atherosclerotic disease. With an AAA mice model created by treatment with porcine pancreatic elastase (PPE) and β-aminopropionitrile (BAPN), this work was designed to explore whether colchicine could protect against the development of AAA. Here, we showed that colchicine could limit AAA formation, as evidenced by the decreased total aortic weight per body weight, AAA incidence, maximal abdominal aortic diameter and collagen deposition. We also found that colchicine could prevent the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally, it was proved that the protective action of colchicine against AAA formation was mainly mediated by preventing immune cells infiltration to the aortic wall. In summary, our findings demonstrated that colchicine could protect against the development of experimental AAA, providing a potential therapeutic strategy for AAA intervention in the clinic.
The Impact of Treating Bilingual Clients on Speech-Language Pathology Students' Cultural Responsiveness
Authors: Wolford Laura L. , Wolford George W. , Smith Lúcia , Clement Alexis , de Diego-Lázaro Beatriz 
Published: September 2023

Purpose:
Graduate programs often use practicum experience with clients from nonmajority cultures to improve students' cultural responsiveness. Yet, it is not clear whether simply working with a client from a nonmajority culture actually confers this benefit or whether students are thinking about how to include culturally responsive behaviors when they are considering how to address a clinical case.

Method:

Twenty first-year speech-language pathology graduate students (10 Spanish–English bilinguals, 10 monolingual English speakers) were split into three groups: monolingual experimental (
n =
4), bilingual experimental (
n =
4), and control (
n =
12). The experimental groups completed a structured practicum with bilingual Hispanic/Latino clients. They received a 1-hr training in cultural responsiveness and then implemented a systematic language intervention in English or Spanish. Changes to cultural responsiveness were measured via think-aloud cases, and changes to confidence were measured with published, self-report scales. Reflective journal entries revealed what aspects of the clinical practicum students found most salient.

Results:
Experience working with bilingual clients did not have a substantial effect on students' confidence in their cultural competence. No substantial change was found in cultural responsiveness on the think-aloud for any group. Cultural responsiveness did not appear to be top-of-mind for the students.

Conclusions:
Simply working with clients from nonmajority cultures does not create a scenario where cultural responsiveness is likely to improve. Additional targeted, purposeful training in cultural responsiveness is necessary.
Speech and Language Assessment for Urdu Speakers in the United States
Authors: Roepke Elizabeth , Alvi Hiba 
Published: September 2023

Purpose:
This aim of this tutorial was to review assessment tools for speech-language pathologists working with Urdu speakers in the United States.

Method:
We outlined cultural and linguistic considerations for speech-language pathologists to consider when assessing Urdu speakers. We also reviewed available Urdu-language tests for pediatric and adult populations by their assessment area and evaluated whether they had been validated for Urdu speakers.

Results:
Speech-language pathologists should consider the impact of cultural and linguistic differences when planning assessment. In particular, many Urdu speakers are Muslim; hence, clinicians unfamiliar with the religion should open communication with clients about assessment preferences. Testing instruments covering the major areas of speech-language pathology are available for Urdu speakers in the United States.

Conclusions:

Speech-language pathologists can use the tools presented in this tutorial to evaluate both body impairments for Urdu speakers and the impact on an individual's participation. A summary of resources for Urdu speakers with links to assessments is provided in
Supplemental Material S1
.

Supplemental Material:

https://doi.org/10.23641/asha.24147564
An AI powered system to enhance self‐reflection practice in coaching
Authors: Jelodari Mahdi , Amirhosseini Mohammad Hossein , Giraldez‐Hayes Andrea 
Published: September 2023

AbstractSelf‐reflection practice in coaching can help with time management by promoting self‐awareness. Through this process, a coach can identify habits, tendencies and behaviours that may be causing distraction or make them less productive. This insight can be used to make changes in behaviour and establish new habits that promote effective use of time. This can also help the coach to prioritise goals and create a clear roadmap. An AI powered system has been proposed that maps the conversion onto topics and relations that could help the coach with note‐taking and progress identification throughout the session. This system enables the coach to actively self‐reflect on time management and make sure the conversation follows the target framework. This will help the coach to better understand the goal setting, breakthrough moment, and client accountability. The proposed end‐to‐end system is capable of identifying coaching segments (Goal, Option, Reality, and Way forward) across a session with 85% accuracy. Experimental evaluation has also been conducted on the coaching dataset which includes over 1k one‐to‐one English coaching sessions. In regards to the novelty, there are no datasets of such nor study of this kind to enable self‐reflection actively and evaluate in‐session performance of the coach.
Einfluss von Ober- und Untertönen auf die Melodieerkennung mit einem Cochlea-Implantat bei SSD
Authors: Schulz Kira Viviane , Gauer Johannes , Martin Rainer , Völter Christiane 
Published: September 2023

ZusammenfassungViele Träger*innen eines Cochlea-Implantats (CI) können Tonhöhen und Melodien schlecht erkennen, da die Tonhöhenübertragung unscharf und verschoben ist. Diese Studie untersucht, ob postlingual ertaubte erwachsene CI-Träger*innen Melodien besser erkennen, wenn Obertöne entfernt oder Untertöne hinzugefügt werden.Eingeschlossen wurden 15 einseitig postlingual ertaubte CI-Träger*innen (Single Sided Deafness, SSD) im Alter von 22–73 Jahren (MW 52, SD 11,6) mit einer CI-Hörerfahrung zwischen 3 und 75 Monaten (MW 33, SD 21,0) mit verschiedenen MED-EL-Modellen. Drei kurze Klaviermelodien wurden ihnen zunächst auf dem normalhörenden Ohr und dann in veränderten Ober- oder Untertonvarianten und der Originalvariante auf dem CI-Ohr präsentiert. Die Varianten sollten als eine der 3 Originalmelodien identifiziert werden. Zusätzlich wurden die musikalischen Fähigkeiten und Erfahrungen durch den Münchner Musikfragebogen und den MiniPROMS-Musiktest erfasst.Die Melodieerkennung gelang den CI-Träger*innen am besten in der Grundfrequenzvariante. Die Obertonvariante mit dem dritten Oberton ergab eine gleichwertige Melodieerkennung wie die Originalvariante aus allen Obertönen (p=1). Indes wurde die Untertonvariante mit dem ersten Unterton signifikant schlechter als die Grundfrequenzvariante erkannt (p=0,032). Ferner zeigte sich keine Korrelation zwischen der Musikerfahrung oder den musikalischen Fähigkeiten und der Anzahl an erkannten Melodien (p>0,1).Da die Obertonreduktion die Melodieerkennung nicht verschlechtert und in anderen Arbeiten den Musikgenuss sogar verbesserte, sollte die Obertonreduktion in künftigen Musikverarbeitungsprogrammen für das CI berücksichtigt werden. Dies könnte zusätzlich den Energieverbrauch des CI reduzieren.
SpECi – Spiritual und Existential Care interprofessionell:
Kurzvorstellung eines Modellprojekts zur spirituellen Begleitung am Lebensende,
seiner Ziele und erwarteten Effekte
Authors: Gerundt Mareike , Büssing Arndt , Giebel Astrid 
Published: September 2023

ZusammenfassungUntersuchungen zeigen den großen Bedarf, existenzielle und
spirituelle Bedürfnisse von akut oder chronisch erkrankten und vor
allem von älteren schwerkranken und sterbenden Menschen wahrzunehmen
und diesen kompetent zu begegnen. Spiritual Care wird zwar in Definitionen
und Leitlinien als unverzichtbare Dimension von Palliative Care
aufgeführt, es bleibt jedoch unklar, wie sie personell, strukturell
und organisatorisch im Gesundheitswesen realisiert werden kann.Mit dem Modellprojekt „Spiritual/Existential Care
interprofessionell“ (SpECi) wird als primäres Ziel die
Verbesserung der Lebensqualität von
Patient*innen/Bewohner*innen in der letzten
Lebensphase verfolgt.An sieben Modellstandorten wurden Mitarbeitende in Krankenhäusern,
Einrichtungen der Altenpflege, stationären Hospizen und
Palliativstationen im Zeitraum von August 2021 bis Mai 2022 in einer
40-stündigen Qualifizierung in Spiritual/Existential Care
geschult. Die geschulten Multiplikatoren (haupt- und ehrenamtlich
Tätige) aus verschiedenen Gesundheitsberufen sollen befähigt
werden, den Spiritual-Care-Ansatz in den alltäglichen Arbeitskontext
zu integrieren. Die wissenschaftliche Begleitforschung zu den
Wirkungsfaktoren der Multiplikatorenschulung in und damit auch durch
Spiritual/Existential Care hilft, das vorliegende Modell zu
evaluieren und weitere Maßnahmen zu einer Verbesserung der
spirituellen Sorge um ältere und sterbende Menschen in den
Einrichtungen des Gesundheitswesens zu entwickeln. Der
Durchführungszeitraum des von der Stiftung Wohlfahrtspflege NRW
geförderten Projekts reicht vom 01.10.2020 bis 30.09.2023. Aktuell
befindet sich das Modellprojekt in der letzten von drei
Befragungsphasen.
High-Dose Rate Brachytherapy Combined with PD-1 Blockade as a
Treatment for Metastatic Adrenocortical Carcinoma – A Single Center Case
Series
Authors: Schwarzlmueller Paul , Corradini Stefanie , Seidensticker Max , Zimmermann Petra , Schreiner Jochen , Maier Tanja , Triebig Alexandra , Knösel Thomas , Pazos Montserrat , Pfluger Thomas , Weigand Isabel , Belka Claus , Ricke Jens , Reincke Martin , Schmidmaier Ralf , Kroiss Matthias 
Published: September 2023

AbstractThe response rate of advanced adrenocortical carcinoma (ACC) to standard
chemotherapy with mitotane and etoposide/doxorubicin/cisplatin
(EDP-M) is unsatisfactory, and benefit is frequently short lived. Immune
checkpoint inhibitors (CPI) have been examined in patient’s refractory
to EDP-M, but objective response rates are only approximately 15%.
High-dose rate brachytherapy (HDR-BT) is a catheter-based internal radiotherapy
and expected to favorably combine with immunotherapies. Here we describe three
cases of patients with advanced ACC who were treated with HDR-BT and the CPI
pembrolizumab. None of the tumors were positive for established response markers
to CPI. All patients were female, had progressed on EDP-M and received external
beam radiation therapy for metastatic ACC. Pembrolizumab was initiated 7 or 23
months after brachytherapy in two cases and prior to brachytherapy in one case.
Best response of lesions treated with brachytherapy was complete (n=2)
or partial response (n=1) that was ongoing at last follow up after 23,
45 and 4 months, respectively. Considering all sites of tumor, response was
complete and partial remission in the two patients with brachytherapy prior to
pembrolizumab. The third patient developed progressive disease with severe
Cushing’s syndrome and died due to COVID-19. Immune-related adverse
events of colitis (grade 3), gastroduodenitis (grade 3), pneumonitis (grade 2)
and thyroiditis (grade 1) occurred in the two patients with systemic response.
HDR-BT controlled metastases locally. Sequential combination with CPI therapy
may enhance an abscopal antitumoral effect in non-irradiated metastases in ACC.
Systematic studies are required to confirm this preliminary experience and to
understand underlying mechanisms.
Geriatrisches Assessment – Was sollte vor Therapiebeginn des mHSPC und des mCRPC gemacht und bedacht werden?
Authors: Heers Hendrik , Butea-Bocu Marius Cristian , Groeben Christer , Huber Johannes , Wullich Bernd , Goebell Peter J. , Fiebig Christian 
Published: September 2023

Zusammenfassung

Bei der medikamentösen Therapie des Prostatakarzinoms stehen zunehmend Kombinationstherapien im Vordergrund. Für ältere und vorerkrankte Patienten sollten einige Aspekte bei der Therapieauswahl und -durchführung beachtet werden, um Toxizitäten zu vermeiden und sowohl Behandlungserfolg als auch Lebensqualität zu gewährleisten. Zur Definition von geriatrischen Patienten sind nicht in erster Linie das chronologische Alter, sondern vor allem der ganzheitliche Gesundheitszustand und die Lebenserwartung entscheidend. Vorerkrankte Patienten > 70 Jahre sollten vor Therapieeinleitung ein dreischrittiges geriatrisches Screening durchlaufen. Bei Auffälligkeiten im G8-Screening-Fragebogen und/oder mini-COG (berücksichtigt werden die Aspekte Nutrition, Komorbidität/-medikation, Mobilität und Kognition) wird ein vereinfachtes geriatrisches Assessment empfohlen. Es erfolgt eine Risikostratifizierung der Patienten in 3 Gruppen (fit, vulnerabel, gebrechlich). Nur in Einzelfällen ist ein komplettes geriatrisches Assessment erforderlich. Behandelbare Defizite in den genannten Bereichen sollten nach Möglichkeit verbessert werden. Bei der Auswahl der Systemtherapie können fitte Patienten analog zu nicht-geriatrischen Patienten behandelt werden. Vulnerable und gebrechliche Patienten haben in der Regel ein höheres Risiko für Toxizitäten, sodass hier besondere Vorsicht geboten ist. Während die verschiedenen Substanzen der Hormontherapie in der Regel gut vertragen werden (wobei einige wirkstoffspezifische Toxizitäten häufiger auftreten können), bestehen bei hämatotoxischen Substanzen wie Taxanen oder Olaparib Empfehlungen zum eingeschränkten Einsatz. Da Sturzereignisse – insbesondere unter Hormontherapie – ein häufiges Problem darstellen, sollte die Osteoprotektion besonders berücksichtigt werden. Bei Fortschreiten der Tumorerkrankung sollte nicht reflexhaft eine Umstellung der Systemtherapie erfolgen, sondern zusammen mit dem Patienten und seinen Angehörigen ein individuelles Konzept unter Berücksichtigung von palliativmedizinischen und Versorgungsaspekten erstellt werden, das die Lebensqualität in den Mittelpunkt stellt und auch Therapielimitationen festlegt.
EFSUMB Technical Review – Update 2023: Dynamic Contrast-Enhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion
Authors: Dietrich Christoph F. , Correas Jean-Michel , Cui Xin-Wu , Dong Yi , Havre Roald Flesland , Jenssen Christian , Jung Ernst Michael , Krix Martin , Lim Adrian , Lassau Nathalie , Piscaglia Fabio 
Published: September 2023

AbstractDynamic contrast-enhanced ultrasound (DCE-US) is a technique to quantify tissue perfusion based on phase-specific enhancement after the injection of microbubble contrast agents for diagnostic ultrasound. The guidelines of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) published in 2004 and updated in 2008, 2011, and 2020 focused on the use of contrast-enhanced ultrasound (CEUS), including essential technical requirements, training, investigational procedures and steps, guidance regarding image interpretation, established and recommended clinical indications, and safety considerations. However, the quantification of phase-specific enhancement patterns acquired with ultrasound contrast agents (UCAs) is not discussed here. The purpose of this EFSUMB Technical Review is to further establish a basis for the standardization of DCE-US focusing on treatment monitoring in oncology. It provides some recommendations and descriptions as to how to quantify dynamic ultrasound contrast enhancement, and technical explanations for the analysis of time-intensity curves (TICs). This update of the 2012 EFSUMB introduction to DCE-US includes clinical aspects for data collection, analysis, and interpretation that have emerged from recent studies. The current study not only aims to support future work in this research field but also to facilitate a transition to clinical routine use of DCE-US.