bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Wafer‐Scale Nanoporous 2D Active Pixel Image Sensor Matrix with High Uniformity, High Sensitivity, and Rapid Switching
Authors: Park Heekyeong , Sen Anamika , Kaniselvan Manasa , AlMutairi AbdulAziz , Bala Arindam , Lee Luke P. , Yoon Youngki , Kim Sunkook 
Published: February 2023

Abstract2D transition‐metal dichalcogenides (TMDs) have been successfully developed as novel ubiquitous optoelectronics owing to their excellent electrical and optical characteristics. However, active‐matrix image sensors based on TMDs have limitations owing to the difficulty of fabricating large‐area integrated circuitry and achieving high optical sensitivity. Herein, a large‐area uniform, highly sensitive, and robust image sensor matrix with active pixels consisting of nanoporous molybdenum disulfide (MoS2) phototransistors and indium–gallium–zinc oxide (IGZO) switching transistors is reported. Large‐area uniform 4‐inch wafer‐scale bilayer MoS2 films are synthesized by radio‐frequency (RF) magnetron sputtering and sulfurization processes and patterned to be a nanoporous structure consisting of an array of periodic nanopores on the MoS2 surface via block copolymer lithography. Edge exposure on the nanoporous bilayer MoS2 induces the formation of subgap states, which promotes a photogating effect to obtain an exceptionally high photoresponsivity of 5.2 × 104 A W−1. A 4‐inch‐wafer‐scale image mapping is successively achieved using this active‐matrix image sensor by controlling the device sensing and switching states. The high‐performance active‐matrix image sensor is state‐of‐the‐art in 2D material‐based integrated circuitry and pixel image sensor applications.
A phylogenomic analysis of Lonicera and its bearing on the evolution of organ fusion
Authors: Srivastav Mansa , Clement Wendy L. , Landrein Sven , Zhang Jingbo , Howarth Dianella G. , Donoghue Michael J. 
Published: February 2023

AbstractPremiseThe ~140 species of Lonicera are characterized by variously fused leaves, bracteoles, and ovaries, making it a model system for studying the evolution and development of organ fusion. However, previous phylogenetic analyses, based mainly on chloroplast DNA markers, have yielded uncertain and conflicting results. A well‐supported phylogeny of Lonicera will allow us to trace the evolutionary history of organ fusion.MethodsWe inferred the phylogeny of Lonicera using restriction site–associated DNA sequencing (RADSeq), sampling all major clades and 18 of the 23 subsections. This provided the basis for inferring the evolution of five fusion‐related traits.ResultsRADSeq data yielded a well‐resolved and well‐supported phylogeny. The two traditionally recognized subgenera (Periclymenum and Chamaecerasus), three of the four sections (Isoxylosteum, Coeloxylosteum, and Nintooa), and half of the subsections sampled were recovered as monophyletic. However, the large and heterogeneous section Isika was strongly supported as paraphyletic. Nintooa, a clade of ~22 mostly vine‐forming species, including L. japonica, was recovered in a novel position, raising the possibility of cytonuclear discordance. We document the parallel evolution of fused leaves, bracteoles, and ovaries, with rare reversals. Most strikingly, complete cupules, in which four fused bracteoles completely enclose two unfused ovaries, arose at least three times. Surprisingly, these appear to have evolved directly from ancestors with free bracteoles instead of partial cupules.ConclusionsWe provide the most comprehensive and well‐supported phylogeny of Lonicera to date. Our inference of multiple evolutionary shifts in organ fusion provides a solid foundation for in depth developmental and functional analyses.
DHEAS and nutritional status among Sidama, Ngandu, and Aka children: Effects of cortisol and implications for adrenarche
Authors: Helfrecht Courtney , Wang Hui , Dira Samuel J. , DeAvila David , Meehan Courtney L. 
Published: February 2023

AbstractObjectiveAdrenarche, the biological event marked by rising production of dehydroepiandrosterone and its sulfate (DHEAS), may represent a sensitive period in child development, with important implications for adolescence and beyond. Nutritional status, particularly BMI and/or adiposity, has long been hypothesized as a factor in DHEAS production but findings are inconsistent, and few studies have examined this among non‐industrialized societies. In addition, cortisol has not been included in these models. We here evaluate effects of height‐ (HAZ), weight‐ (WAZ), and BMI‐ (BMIZ) for‐age on DHEAS concentrations among Sidama agropastoralist, Ngandu horticulturalist, and Aka hunter‐gatherer children.MethodsHeights and weights were collected from 206 children aged 2–18 years old. HAZ, WAZ, and BMIZ were calculated using CDC standards. DHEAS and cortisol assays were used to determine biomarker concentrations in hair. Generalized linear modeling was used to examine effects of nutritional status on DHEAS concentrations, as well as cortisol, controlling for age, sex, and population.ResultsDespite the prevalence of low HAZ and WAZ scores, the majority (77%) of children had BMI z‐scores >−2.0 SD. Nutritional status has no significant effect on DHEAS concentrations, controlling for age, sex, and population. Cortisol, however, is a significant predictor of DHEAS concentrations.ConclusionsOur findings do not support a relationship between nutritional status and DHEAS. Instead, results suggest an important role for stress and ecology in DHEAS concentrations across childhood. Specifically, effects of environment via cortisol may be influential to patterning of DHEAS. Future work should investigate local ecological stressors and their relationship to adrenarche.
RNA methyltransferase BmMettl3 and BmMettl14 in silkworm (Bombyx mori) and the regulation of silkworm embryonic development
Authors: Li Bing , Hu Pei , Huang Zhi‐Hao , Yang Jia‐Yue , Wang Jie , Xie Xiu‐Zhi , Wang Yu‐Han , Li Chen‐Chen , Xu Jia‐Ping 
Published: February 2023

AbstractN6‐methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in regulating many biological processes, especially embryonic development. However, regulation of m6A methylation during silkworm embryonic development and diapause remains to be investigated. In this study, we analyzed the phylogeny of subunits of methyltransferases BmMettl3 and BmMettl14, and detected the expression patterns of BmMettl3 and BmMettl14 in different tissues and at different developmental stages in silkworm. To investigate the function of m6A on the development of silkworm embryo, we analyzed the m6A/A ratio in diapause and diapause termination eggs. The results showed that BmMettl3 and BmMettl14 were highly expressed in gonads and eggs. Moreover, the expression of BmMettl3 and BmMettl14 and the m6A/A ratio were significantly increased in diapause termination eggs compared with diapause eggs in the early stage of silkworm embryonic development. Furthermore, in BmN cell cycle experiments, the percentage of cells in the S phase increased when lacking BmMettl3 or BmMettl14. This work contributes to understanding the role of m6A methylation during insect embryogenesis and gametogenesis. It also provides a research orientation to further analyze the role of m6A methylation in diapause initiation and termination during insect embryonic development.
Multiple schedules with response interruption and redirection to reduce stereotypy in children with autism spectrum disorder: Generalization and social validity
Authors: Callahan Ashley E. , Sidener Tina M. , DeBar Ruth M. , Deshais Meghan A. , Pane Heather M. , Patil Priya 
Published: February 2023

AbstractAlthough response interruption and redirection (RIRD) and multiple schedule arrangements have sometimes been shown to be effective in reducing stereotypy for individuals with autism spectrum disorder (ASD), important questions remain about optimal methods for facilitating generalization and social validity. In the current study, we sought to extend the literature on stereotypy treatment and MSAs in several ways. First, we programmed for generalization by conducting sessions with two exemplars of two different categories of activities (i.e., school work, toy play) and assessing generalization with novel exemplars and activities and during the participant's typical instructional program. Second, we used RIRD instructions that were contextual models of appropriate behavior relevant to each activity. Third, during the free access component of the multiple schedule, we used a child's play tent as a first step toward teaching participants to engage in stereotypy during private free time. For all three participants with ASD, stereotypy decreased quickly and substantially, with reductions generalizing to novel activities and contexts. An extensive social validity assessment with board‐certified behavior analysts indicated high social acceptability of the goals, procedures, and outcomes.
Outcomes with plug‐based versus suture‐based vascular closure device after transfemoral transcatheter aortic valve replacement: A systematic review and meta‐analysis
Authors: Sedhom Ramy , Dang Alexander T. , Elwagdy Amr , Megaly Michael , Elgendy Islam Y. , Zahr Firas , Gafoor Samir , Mamas Mamas , Elbadawi Ayman 
Published: February 2023

AbstractBackgroundStudies comparing plug‐based (i.e., MANTA) with suture‐based (i.e., ProStar XL and ProGlide) vascular closure devices (VCDs) for large‐bore access closure after transcatheter aortic valve replacement (TAVR) have yielded mixed results.AimsTo examine the comparative safety and efficacy of both types of VCDs among TAVR recipients.MethodsAn electronic database search was performed through March 2022 for studies comparing access‐site related vascular complications with plug‐based versus suture‐based VCDs for large‐bore access site closure after transfemoral (TF) TAVR.ResultsTen studies (2 randomized controlled trials [RCTs] and 8 observational studies) with 3113 patients (MANTA = 1358, ProGlide/ProStar XL = 1755) were included. There was no difference between plug‐based and suture‐based VCD in the incidence of access‐site major vascular complications (3.1% vs. 3.3%, odds ratio [OR]: 0.89; 95% confidence interval [CI]: 0.52−1.53). The incidence of VCD failure was lower in plug‐based VCD (5.2% vs. 7.1%, OR: 0.64; 95% CI: 0.44−0.91). There was a trend toward a higher incidence of unplanned vascular intervention in plug‐based VCD (8.2% vs. 5.9%, OR: 1.35; 95% CI: 0.97−1.89). Length of stay was shorter with MANTA. Subgroup analyses suggested significant interaction based on study designs such that there was higher incidence of access‐site vascular complications and bleeding events with plug‐based versus suture‐based VCD among RCTs.ConclusionIn patients undergoing TF‐TAVR, large‐bore access site closure with plug‐based VCD was associated with a similar safety profile as suture‐based VCD. However, subgroup analysis showed that plug‐based VCD was associated with higher incidence of vascular and bleeding complications in RCTs.
The impact of chronic total occlusions in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis
Authors: Will Maximilian , Schwarz Konstantin , Weiss Thomas , Leibundgut Gregor , Lamm Gudrun , Vock Paul , Mascherbauer Julia , Kwok Chun Shing 
Published: February 2023

AbstractCoronary artery disease (CAD) is frequently encountered in patients evaluated for transcatheter aortic valve replacement (TAVR) due to severe aortic stenosis. The prognostic relevance of chronic total occlusions (CTOs) in this setting is poorly understood. We conducted a search of MEDLINE and EMBASE to identify studies evaluating patients who underwent TAVR and evaluated outcomes depending on the presence of coronary CTOs. Pooled analysis was performed to estimate the rate and risk ratio for mortality. Four studies involving 25,432 patients fulfilled the inclusion criteria. The follow up ranged from in‐hospital outcomes to 8‐years follow‐up. Coronary artery disease was present in 67.8% to 75.5% of patients in 3 studies which reported this variable. The prevalence of CTOs varied between 2% and 12.6% in this cohort. The presence of CTOs was associated with increase in length of stay (8.1 ± 8.2 vs. 5.9 ± 6.5, p < 0.01), cardiogenic shock (5.1% vs. 1.7%, p < 0.01), acute myocardial infarction (5.8% vs. 2.8%, p = 0.02) and acute kidney injury (18.6% vs. 13.9%, p = 0.048). The pooled 1‐year death rate revealed 41 deaths in 165 patients in the CTO group and 396 deaths in 1663 patients with no CTO ((24.8%) vs. (23.8%)). The meta‐analysis of death with CTO versus no CTO showed a nonsignificant trend toward increased mortality with CTOs (risk ratio 1.11 95% CI 0.90–1.40, I2 = 0%). Our analysis suggests that concomitant CTO lesions in patients undergoing TAVR are common, and its presence was associated with increased in‐hospital complications. However, CTO presence by itself was not associated with increased long‐term mortality, only a nonsignificant trend toward an increased risk of death in patients with CTO was found. Further studies are warranted to assess the prognostic relevance of CTO lesion in TAVR patients.
Distal versus conventional radial artery access for coronary catheterization: A systematic review and meta‐analysis
Authors: Feghaly Julien , Chen Kai , Blanco Anamarys , Pineda Andres M. 
Published: February 2023

AbstractBackgroundThe distal radial artery (DRA) access is an alternative to the conventional radial artery (CRA) access for coronary angiography and interventions and appears to be associated with reduced incidence of certain outcomes.MethodsA systematic review was performed to evaluate differences between DRA versus CRA access for coronary angiography and/or interventions. Following preferred reporting items for systematic review and meta‐analysis‐protocols guidelines, two reviewers independently selected studies published in the electronic databases (MEDLINE, EMBASE, SCOPUS, CENTRAL) from inception to October 10, 2022, followed by data extraction, meta‐analysis, and quality assessment.ResultsThe final review included 28 studies with (total: 9151 patients [DRA: 4474; CRA: 4677]). Compared with CRA, DRA access was found to be associated with a shorter time to achieve hemostasis (mean difference, MD: −32.49 [95% confidence interval, CI: −65.53, −2.46], p < 0.00001), and reduced incidence of radial artery occlusion (RAO) (risk ratio, RR: 0.38 [95% CI: 0.25, 0.57], p < 0.00001), any bleeding (RR: 0.44 [95% CI: 0.22, 0.86], p = 0.02), and pseudoaneurysm (RR: 0.41 [95% CI: 0.18, 0.99], p = 0.05). However, DRA access has increased access time (MD: 0.31 [95% CI: −0.09, 0.71], p < 0.00001) and crossover rates (RR: 2.75 [95% CI: 1.70, 4.44], p < 0.00001). There were no statistically significant differences in other technical aspects and complications.ConclusionDRA access is a safe and feasible approach for coronary angiography and interventions. Compared to CRA, DRA provides a shorter hemostasis time, lower incidence of RAO, any bleeding, and pseudoaneurysm, and is associated with increased access time and crossover rates.
Comparison of push‐out bond strength of endodontic sealers after root canal drying with different techniques
Authors: Sarrafan Ahmadreza , Soleymani Ali , Bagheri Chenari Tasnim , Seyedmajidi Seyedali 
Published: February 2023

AbstractObjectivesAn ideal endodontic sealer should bond to both dentin and root‐filling material. This study aimed to assess the push‐out bond strength (PBS) of mineral trioxide aggregate (MTA)‐Fillapex, Endoseal MTA, AH26, and Sure‐Seal Root to root dentin after root canal drying with different techniques.Materials and MethodsThis in vitro study was conducted on 160 extracted mandibular premolars. After root canal preparation, the teeth were randomly divided into four groups (n = 40) of drying with ethanol, paper point, air vacuum, and control (wet canal). Each group was divided into four subgroups (n = 10) for use of AH26, Sure‐Seal Root, MTA‐Fillapex, and Endoseal MTA sealers. The mean PBS was measured by a universal testing machine. The mode of failure was determined under a stereomicroscope. Data were analyzed by the Kruskal–Wallis and Games–Howell tests.ResultsThe maximum mean PBS was equally recorded in ethanol and paper point groups, and was significantly higher than that of control and air vacuum groups (p < .001). In the use of AH26 sealer, the mean PBS in drying with ethanol was significantly higher than all other methods (p < .05). The mean PBS in drying with a paper point was also significantly higher compared with control and air vacuum methods (p < .05). In the use of Sure‐Seal, the mean PBS in drying with a paper point was significantly higher than other methods (p < .05). The mean PBS in drying with ethanol was significantly higher than that in control and air vacuum methods (p < .001). In the use of MTA‐Fillapex and Endoseal‐MTA, the technique of drying had no significant effect on PBS. Adhesive and mixed failures were the most common in all drying groups.ConclusionsDrying with ethanol and paper point enhanced the PBS of sealers to root dentin.
Beyond bacteria: Reconstructing microorganism connections and deciphering the predicted mutualisms in mammalian gut metagenomes
Authors: Dai Qinlong , Ding Jingjing , Cui Xinyuan , Zhu Yudong , Chen Hua , Zhu Lifeng 
Published: February 2023

AbstractNumerous gut microbial studies have focused on bacteria. However, archaea, viruses, fungi, protists, and nematodes are also regular residents of the gut ecosystem. Little is known about the composition and potential interactions among these six kingdoms in the same samples. Here, we unraveled the complex connection among them using approximately 123 gut metagenomes from 42 mammalian species (including carnivores, omnivores, and herbivores). We observed high variation in bacterial and fungal families and relatively low variation in archaea, viruses, protists, and nematodes. We found that some fungi in the mammalian intestine might come from environmental sources (e.g., soil and dietary plants), and some might be native to the intestine (e.g., the occurrence of Neocallimastigomycetes). The Methanobacteriaceae and Plasmodiidae families (archaea and protozoa, respectively) were predominant in these metagenomes, whereas Onchocercidae and Trichuridae were the two most common nematodes, and Siphoviridae and Myoviridae the two most common virus families in these mammalian gut metagenomes. Interestingly, most of the pairwise co‐occurrence patterns were significantly positive among these six kingdoms, and significantly negative networks mainly occurred between fungi and prokaryotes (both bacteria and archaea). Our study revealed some inconvenient characteristics in the mammalian gut microorganism ecosystem: (1) the community formed by members of the analyzed kingdoms reflects the life history of the host and the potential threat posed by pathogenic protists and nematodes in mammals; and (2) the networks suggest the existence of predicted mutualism among members of these six kingdoms and of the predicted competition, mainly among fungi and other kingdoms.
An analytical solution for the horizontal vibration behavior of a cylindrical rigid foundation in poroelastic soil layer
Authors: Yang Zijian , Zou Xinjun 
Published: February 2023

AbstractThe large size embedded foundation is widely used in the engineering, but the finite thickness of soil layer underlying this foundation is usually neglected in design, which leads to the non‐negligible error of calculation. By virtue of Biot's elastodynamic theory, this paper proposes a simple method to discuss the horizontal dynamic response of the cylindrical rigid foundation partially embedded in a poroelastic soil layer. First, based on the Novak plane strain model, the shaft resistance from the surrounding soil is simulated and solved. Second, the foundation end soil is assumed as a continuous medium of finite thickness, whose initial mechanism is derived from the dynamic interaction between the rigid disk and soil. Finally, the horizontal dynamic response factor is calculated by adopting newton's second law. Several cases are set to verify the rationality of the presented solution and to develop the analysis of key parameters. The numerical results suggest that the soil layer thickness has a significant influence on the dynamic vibration of the embedded foundation, and its effect is consistent with that of poroelastic half‐space when the thickness exceeds certain value.
Sleep and emotionality in adolescents with anorexia nervosa during the Covid‐19 pandemic
Authors: Rossi Lucia , Silva Catarina , Charvin Isabelle , Da Fonseca David , Bat‐Pitault Flora 
Published: February 2023

AbstractPurposeThe recent Covid‐19 pandemic and its lockdown measures raised concerns about people's mental health, leading to an increased interest in identifying vulnerable groups especially at risk for mental distress. This cross‐sectional study investigated the impact of this unprecedented situation on sleeping patterns and emotionality in adolescents with anorexia nervosa (AN).MethodsVariations in sleeping patterns and emotionality of two groups of adolescents with AN, assessed before (N = 50) and during (N = 51) the Covid‐19 lockdown were analysed. We further investigated these variations over time, considering the two lockdown periods in France.ResultsAdolescents self‐reported significantly more sleep difficulties and lower rates of positive emotions during lockdown, compared to those evaluated before it. Furthermore, present findings overall suggest that as the lockdown progresses, adolescents with AN show an increased deterioration of sleep quality, as indicated by greater insomnia severity levels. They also show a significant decrease in the subjective experience of positive emotionality, in particular in feelings of tenderness.ConclusionsThese sleep and emotionality alterations may have amplified the severity and the incidence of AN in adolescents during the Covid‐19 pandemic. These features may therefore represent therapeutic targets to optimise care of adolescents with AN. This is particularly urgent, considering kinetics of the deterioration. Tools such as those provided by cognitive behavioural therapy for insomnia and by the positive psychology framework seem appropriate to guide clinicians in this context.Level Of EvidenceLevel V, descriptive study (evaluation data retrospectively studied).
Gender differences in individuals with obesity and binge eating disorder: A retrospective comparison of phenotypical features and treatment outcomes
Authors: Brandt Gerrit , Halbeisen Georg , Braks Karsten , Huber Thomas J. , Paslakis Georgios 
Published: February 2023

AbstractObjectivePhenotypical comparisons between individuals with obesity without binge eating disorder (OB) and individuals with obesity and comorbid binge eating disorder (OB + BED) are subject to ongoing investigations. At the same time, gender‐related differences have rarely been explored, raising the question whether men and women with OB and OB + BED may require differently tailored treatments.MethodWe retrospectively compared pre‐ versus post‐treatment data in a matched sample of n = 180 men and n = 180 women with OB or OB + BED who received inpatient treatment.ResultsWe found that men displayed higher weight loss than women independent of diagnostic group. In addition, men with OB + BED showed higher weight loss than men with OB after 7 weeks of treatment.ConclusionsThe present findings add to an emerging yet overall still sparse body of studies comparing phenotypical features and treatment outcomes in men and women with OB and OB + BED; implications for further research are discussed.Clinical Trial RegistrationThe study was prospectively registered with the German Clinical Trial Register as part of application DRKS00028441.