bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical management of hereditary gingival fibromatosis: Case report with 13 years follow‐up
Authors: Dutra Oliveira Alcione Maria Soares , Dutra Oliveira Peterson Antônio , Pereira Tarcísio Junqueira , Costa Fernando Oliveira 
Published: January 2025

AbstractBackgroundHereditary gingival fibromatosis (HGF) is one of the categories of non‐plaque‐induced gingival diseases of genetic origin. Current studies show high genetic heterogeneity and suggest that not all forms of HGF are the same and that more than one biological mechanism may result in gingival growth. This report presents a case of syndromic HGF with generalized and complex clinical manifestations associated with other conditions such as body hypertrichosis and hearing deficit.MethodsThis is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at the age of 8 and was completed by 21.Results and ConclusionsThe results of this case report demonstrated the importance of early diagnosis and the establishment of a correct treatment plan that provided, in the long‐term, highly positive effects, minimizing impacts affecting the oral health‐related quality of life of individuals with HGF.Key points
This is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at age 8 and was completed by age 21.
Clinical, genetic, and histological data are reported over the 13 years of follow‐up.
Due to the numerous complications caused by HGF, early diagnosis and the establishment of an appropriate treatment plan are imperative.
Bilateral Orocutaneous Fistula Secondary to Pericoronal Infection of Mandibular Third Molars: A Rare Case Report
Authors: K. C. Karina , Kalwar Ankit Gupta , Upadhyaha Chandan , Chaurasia Nitesh , Shakya Mamata 
Published: January 2025

ABSTRACTOdontogenic cutaneous fistulas are abnormal connections between the oral cavity and skin, often mistaken for skin infections. They typically result from dental infections but may also arise from salivary gland issues, tumors, or congenital anomalies. Accurate diagnosis is essential to prevent complications like infection, osteomyelitis, and discomfort. A 26‐year‐old woman presented with bilateral facial lesions and itching for the past year. Her symptoms began 5 years earlier with cheek pain and swelling, initially treated with antibiotics. Examination revealed pericoronitis of the mandibular third molars, leading to bilateral orocutaneous fistulas. Surgical removal of the affected teeth and fistulas was performed. Orocutaneous fistulas commonly result from long‐standing dental infections. Their location depends on the perforation site of the cortical plate. Early diagnosis through clinical examination and imaging is vital to prevent severe complications like osteomyelitis. Treatment involves addressing the underlying cause, typically through root canal therapy or tooth extraction. This case highlights the importance of early, interdisciplinary management of orocutaneous fistulas to prevent misdiagnosis, reduce discomfort, and avoid complications. Timely treatment ensures better outcomes and minimizes cosmetic concerns.
Simulation Model Exchange in Process Industry: Requirements, Solutions, and Open Challenges
Authors: Mädler Jonathan , Serrano Claudia Guadarrama , Viedt Isabell , Farkas Tamás , Semrau Julia , Otten Wilhelm , Krämer Stefan , Schüller Andreas 
Published: January 2025

AbstractSimulation models are crucial for various applications across the lifecycle of process plants, such as plant engineering. As the industry moves toward modularization, plant components are increasingly supplied by manufacturers who design these modular units, often called package units or process equipment assemblies. Consequently, critical knowledge about their behavior resides with the manufacturers. This paper outlines the requirements for simulation model exchange to share this behavioral knowledge. It reviews solutions and highlights challenges based on literature and case studies. Key elements include metadata, open standards, IP protection, and quality assurance. Solutions, like the asset administration shell (AAS), CAPE‐OPEN, the Functional Mock‐up Interface (FMI), encrypted models, and quality models, are discussed. Remaining gaps are highlighted.
Pyridoxal phosphate binding protein (PLPBP) deficiency mimicking opsoclonus‐myoclonus‐ataxia syndrome
Authors: Takle Mrinmayee , Sahjwani Dhwani , Bharucha‐Goebel Diana , Rapp Tyler , Bouska Cecilia , Kornbluh Alexandra , Sen Kuntal 
Published: January 2025

AbstractIntroductionGenetic and metabolic conditions can mimic diagnoses such as hypoxic‐ischemic encephalopathy, meningoencephalitis, epilepsy, and opsoclonus‐myoclonus‐ataxia syndrome (OMAS). Without a high index of suspicion and proper testing, diagnoses can be missed, and treatment delayed.MethodsA 3‐year‐old girl with a history of neonatal seizures and previous nondiagnostic epilepsy gene panel presented with seizures, behavioral changes, and discrete episodes of myoclonus, tremors, and abnormal eye movements following a viral illness.Objective and InterpretationInitial evaluation was concerning for OMAS, though metabolic causes remained on the differential. Metabolic testing revealed elevated glycine and glutamine, suggestive of a possible inborn error of metabolism. Whole exome sequencing demonstrated compound heterozygous variants in the PLPBP gene associated with pyridoxine‐dependent epilepsy (PDE), consistent with her clinical presentation and leading to her diagnosis of PLPBP deficiency.DiscussionClinicians should gauge the indications, advantages, and limitations of targeted sequencing panels versus whole exome sequencing. Continued evaluation is recommended in patients with a history of neonatal and infantile epilepsy, especially if they present with episodic crises related to viral illness even if prior genetic and metabolic investigations have been nondiagnostic. This report also highlights the clinical overlap between PLPBP deficiency and OMAS, and the differences in pathophysiology, treatment pathways, and implications.
Artificial Intelligence Application in Diagnosing, Classifying, Localizing, Detecting and Estimation the Severity of Skin Condition in Aesthetic Medicine: A Review
Authors: Lee Alvin Kar Wai , Chan Lisa Kwin Wah , Lee Cheuk Hung , Bohórquez Jair Mauricio Cerón , Haykal Diala , Wan Jovian , Yi Kyu‐Ho 
Published: January 2025

ABSTRACTBackgroundThe integration of artificial intelligence (AI) and machine learning (ML) has revolutionized aesthetic medicine, enhancing the diagnosis, classification, and treatment of skin conditions. These technologies offer high precision, personalized care, and the potential to reduce human error. This review aimed to evaluate the current applications of AI and ML in aesthetic medicine, focusing on studies graded as Level I or II evidence by the Oxford Centre for Evidence‐Based Medicine (CEBM).MethodsA comprehensive search of MEDLINE, PubMed, and Ovid databases identified studies employing AI and ML for diagnosing and managing skin conditions. Studies were included if they demonstrated high diagnostic accuracy, improved treatment personalization, or other measurable clinical outcomes.ResultsAI and ML systems showed high accuracy in detecting and diagnosing conditions such as skin cancer, acne, psoriasis, and seborrheic dermatitis. AI‐based platforms facilitated personalized treatment plans, enhancing therapeutic outcomes while minimizing errors. The integration of AI reduced diagnostic time and lowered healthcare costs, demonstrating significant potential for improving patient care. However, challenges such as algorithmic bias, data privacy concerns, and the need for high‐quality training datasets were highlighted.ConclusionAI and ML have transformative potential in aesthetic medicine, offering improved diagnostic precision, enhanced patient outcomes, and cost reductions. Addressing limitations related to algorithm bias, regulatory oversight, and data quality is essential to fully realize the benefits of AI in clinical practice. Future research should focus on developing robust, ethical, and regulatory‐compliant AI solutions.
Exploring Experiences of Safety With LGBTQ+ Newcomers in Calgary, Alberta
Authors: Tri Thomas , Warria Ajwang' 
Published: January 2025

ABSTRACTLesbian, gay, bisexual, transgender, queer/questioning, and gender and sexual diverse (LGBTQ+) newcomers arrive in Canada, a country renowned as a “safe haven” for those escaping anti‐LGBTQ+ policies. Despite Canada's reputation, notions of safety are not guaranteed as LGBTQ+ newcomers continue to face systems of oppression as they navigate their new country of residence. Drawing from the feminist affect literature, this study sought to understand how LGBTQ+ newcomers navigate and perceive safety. This study employed an arts‐based method called participatory community mapping as well as semistructured interviews to explore six participants' experiences in Calgary, Canada. The findings of this study suggest the complex and vast experiences of LGBTQ+ newcomers upon settlement. LGBTQ+ newcomers face various challenges, such as discrimination, and navigating cultural differences alongside new systems. While adverse experiences were identified, participants also described spaces that elicit a sense of safety. Entering spaces free of judgment, where one can feel authentic to oneself, and fostering community and a sense of belonging, are critical facets of experiencing safety. Several mechanisms were employed to navigate safety, including concealing one's identity, avoiding diasporic communities, or trusting one's instinct. Feeling safe is not static and inherent in various spaces, but rather, requires complex negotiations with other people and considerations for one's LGBTQ+ identity.
Addressing Unmet Needs in Eating Disorders Requires Systemic Change and Co‐Production: A Commentary on Ali et al. (2024)
Authors: Ayton Agnes , Downs James , Ibrahim Ali 
Published: January 2025

ABSTRACTThe treatment gap for eating disorders varies significantly across healthcare systems owing to structural, cultural, and systemic barriers. A recent systematic review by Ali et al. highlighted this disparity, with treatment rates ranging from 2.3% in some US populations to 65.7% in Switzerland, reflecting differences in methodology, healthcare funding, and accessibility. These gaps are exacerbated by inadequate primary care recognition, long waiting lists, and the prioritization of underweight cases, which marginalize individuals with higher body weights or complex comorbidities. Systemic barriers include fragmented care and insufficient interdisciplinary collaboration, especially for individuals with co‐occurring conditions such as diabetes, other mental disorders, or neurodivergence. Variations in access to evidence‐based treatment also disproportionately affect men, ethnic minorities, and those with newer diagnoses, where a lack of funding and expertise hampers effective intervention. Geographic inequities and reliance on out‐of‐pocket payments further limit access in some systems. Addressing these disparities requires systemic reforms, including improved training and funding, integrated treatment models, and public prevention programs. Embedding lived experience in research, service design, and policy development can ensure inclusive and culturally sensitive interventions. By targeting the unique challenges of each healthcare system, tailored approaches can reduce inequities, improve access to treatment and outcomes.
Mental Defeat Predicts Increased Suicide Risk in Chronic Pain: A 12‐Month Prospective Study
Authors: Themelis Kristy , Gillett Jenna L. , Karadag Paige , Cheatle Martin D. , Ilgen Mark A. , Balasubramanian Shyam , Singh Swaran P. , Tang Nicole K. Y. 
Published: January 2025

ABSTRACTBackgroundMental defeat is considered a potential risk factor for suicidal thoughts and behaviours in chronic pain. This study evaluated the role of mental defeat in predicting future suicide risk and examined whether depression influences this relationship.MethodsA total of 340 participants with chronic pain completed questionnaires at two time points, 12 months apart. Data collected included sociodemographic and pain characteristics, mental defeat, psychosocial risk factors including depression and health‐related variables. Weighted univariate and multivariable analyses assessed the link between mental defeat and suicide risk, with a moderation analysis testing the role of depression.ResultsHigher levels of mental defeat and depression were linked to increased suicide risk at 12 months. Depression significantly amplified the effect of mental defeat on suicide risk, particularly in individuals with higher depression levels (B = 0.06, SE = 0.01, t = 6.21, p < 0.001) compared with moderate (B = 0.05, SE = 0.01, t = 5.20, p < 0.001) or low levels of depression (B = 0.04, SE = 0.01, t = 2.83, p = 0.004), indicating a dose–response relationship.ConclusionsMental defeat is a significant risk factor for suicide in chronic pain, with depression intensifying this risk. Addressing both mental defeat and depression simultaneously in treatment may help reduce suicide risk in these patients.SignificanceThis study strengthens the evidence linking mental defeat with heightened suicide risk in chronic pain. By providing prospective data, it clarifies the temporality of this relationship. Given that suicide risk doubles in chronic pain patients, whereby comorbid depression is common, these findings have crucial clinical implications. Both mental defeat and depression are modifiable. Addressing them together in treatment may help reduce suicide risk in this population.
The Anti‐Inflammatory Activities of Sphagnum palustre L. Ethanol Extract to Control Inflammation in RAW264.7 Cells
Authors: Wu Zhi , Zheng Jiahui , Xu Yang , Wang Dairong , Han Qingbin , Liu Ping , Liu Xiaorong , Zhang Lanyue 
Published: January 2025

ABSTRACTDiscomfort caused by inflammation leads to stress and anxiety in patients and seriously decreases the patients' quality of life. People prefer to use natural products instead of anti‐inflammatory drugs because of their low toxicity and side effects. Studies have shown that Sphagnum palustre L. (S. palustre) can be used as medicinal plant, but few studies have focused on its anti‐inflammatory effects. This study explored the mechanism of action of the ethanol extract of the peat moss plant S. palustre on lipopolysaccharide‐induced inflammation in macrophage RAW264.7 cells. Components in S. palustre ethanol extracts (SPE) were identified by HPLC‐MS, which mainly included 4‐methoxybenzaldehyde, 4‐methoxycinnamaldehyde and oleanolic acid. The effects of different concentrations (6.25–100 μg/mL) of SPE after 24 h administration were evaluated to establish a cellular inflammation model. Three biological replicates were performed based on each experiment, the MTT assay results showed that a low concentration of SPE promoted cell proliferation marked by Formazan. In a neutral red uptake assay, the SPE group was effectively inhibited the cell phagocytosis rate. With the increase of SPE concentration, intracellular ROS release decreased, which detected by DCFH‐DA. Immunofluorescence assay result showed that SPE inhibited the release of reactive oxygen species from macrophages with fluorescent markers and DAPI. SPE inhibited the release of nitric oxide from macrophages as well. What's more, SPE significantly decreased the protein expression of interleukin (IL)‐1, IL‐6, and nuclear factor (NF)‐κB according to enzyme‐linked immunosorbent and immunocytochemical assays. SPE reduces inflammation in macrophage RAW264.7 cells and thus is a promising natural anti‐inflammatory plant.
Retroperitoneal ectopic pregnancy from a tertiary obstetrics hospital in Vietnam: A case series and literature review
Authors: Mai Hung Trong , Le Dao Thi Anh , Nguyen Toan Khac 
Published: January 2025

AbstractRetroperitoneal ectopic pregnancy is an uncommon condition in clinical practice, often associated with misdiagnosis and unconventional treatment. Delayed interventions can lead to poor prognosis and sometimes catastrophic situations. Due to the limited number of reported cases in the literature, an established treatment protocol has yet to be introduced. This case series presents three instances at a tertiary women's hospital in Vietnam. In cases 1 and 2, a single approach—either surgery or a chemo‐regimen—was applied. However, the third patient was treated with a combination of both therapies. This series highlights an evolution in management, progressing from incomplete removal of the gestation to a comprehensive combination of surgery and chemotherapy. Additionally, high serum beta‐human chorionic gonadotropin (β‐hCG) levels and suspicious ultrasound and magnetic resonance imaging (MRI) findings are crucial for establishing the diagnosis.
Investigator‐Initiated Clinical Pharmacokinetic Studies in Resource‐Limited Settings: Minimal Requirements and Practical Guidance
Authors: Uittenboogaard Aniek , Mageto Susan , Mohamed Sherif Kamal Eldin , Pourroy Bertrand , Mwesige Benjamin , Chitedze Agness Chisomo , Kaspers Gertjan , Njuguna Festus 
Published: January 2025

AbstractClinical pharmacology studies are critical for determining the efficacy and safety of drugs. Due to the resource‐intensive nature of these studies, most have been conducted in high‐income countries, leading to a significant gap in clinical pharmacology data for patients in low‐ and middle‐income countries. This paper provides an overview of the minimal requirements for performing a clinical pharmacology investigator‐initiated trial (IIT), including pharmacokinetic sampling. We identify common challenges in resource‐limited settings and propose strategies to overcome them. This guideline covers regulatory approval, participant recruitment, drug storage, sample collection and handling, transport, bioanalytical analysis, and data management tailored to the constraints of resource‐limited settings. Strategies are proposed to minimize resource demands, including simplified study designs, the use of technologies like whole blood microsampling, and opportunities for collaboration. The goal is to provide practical guidance for those seeking to perform a clinical pharmacology IIT in resource‐limited settings to improve safe and effective drug treatment for patients worldwide. Beyond the scope of this guideline is a detailed step‐by‐step guide on how to perform clinical pharmacology studies.
Excess cement and peri‐implant disease: A cross‐sectional clinical endoscopic study
Authors: Montevecchi Marco , Valeriani Leoluca , Salvadori Maria Francesca , Stefanini Martina , Zucchelli Giovanni 
Published: January 2025

AbstractBackgroundCrown cementation is a common technique for implant‐supported prosthodontics. However, for possible slipping of the cement below the mucosal margin, its thorough removal poses some issues. The objective of this study was to evaluate the presence of submucosal cement residues in patients with peri‐implant disease by endoscopic visualization and to investigate the potential correlation between the pathological scenario and the spatial position of cement residues.MethodsThe study sample comprised 46 consecutive patients exhibiting clinical and radiographic signs of peri‐implant disease around cement‐retained crowns. When at first visit bleeding on probing was the only pathological sign, the area was debrided and then treated with antiseptic agents for 30 days. Only those patients for whom bleeding was still found at re‐evaluation were included in the study. All implants were therefore endoscopically evaluated to identify possible submucosal cement residues. For all implants showing residual cement, the spatial position of the residual cement was recorded with respect to predefined points.ResultsCement residues were detected in 80.4% of the patients and were predominantly located in the vestibular and lingual areas (88%). Analysis of the distances between the apical portion of the residues and anatomical landmarks revealed significant differences between mucositis and peri‐implantitis patients (p = 0.001). In cases of peri‐implantitis, the cement residue was more apically located than in mucositis.ConclusionThe presence of cement residue was associated with peri‐implant disorders in the majority of patients. A potential correlation between the position of residues and the peri‐implant disease scenario is here suggested.Plain language summaryA common method for fixing the crown on the dental implant is the use of specific cements. However, these products can slip below the gum line resulting in difficulties in their removal, which could cause peri‐implant disease. This study aimed to evaluate the presence and location of residual cement hidden under the gums in patients with peri‐implant disease, characterized by symptoms such as bleeding gums and, in some cases, bone loss around the dental implant. Using a small fiber‐optic camera (endoscope), 46 patients were examined for any cement residue under the gums. The study showed that more than 80% of patients had cement residues, especially in the areas facing the cheeks and tongue. It was also found that in patients with a more severe form of inflammation (peri‐implantitis), the cement was placed deeper than in those with a milder form (mucositis). This confirms that residual cement is common in patients with peri‐implant disease, but also suggests that its location could influence the severity of the pathological manifestation. This finding highlights the importance of carefully removing all cement to prevent such complications.
Potential effects of prebiotic fibers on dental caries: a systematic review
Authors: Fernández Constanza E. , Maturana‐Valenzuela Catalina , Rojas‐Castillo Nicol , Rosier Bob 
Published: January 2025

AbstractCertain dietary fibers exhibit prebiotic effects on gut microbiota, but their influence on oral health remains unclear. This study conducted a systematic review across four databases to examine the potential effects of dietary fibers on dental caries. Data selection and extraction were conducted independently and in duplicate. From 962 found titles, twenty studies were included, of which 13 were in vitro. The substances identified as prebiotics included fructo‐oligosaccharides (FOS), galacto‐oligosaccharides (GOS), inulin, pectin, raffinose, polydextrose, sialyllactose, and short‐chain fatty acids. Outcomes were assessed at biofilm (n = 14), saliva (n = 5), and tooth (n = 1) levels, with only six studies evaluating pH changes. Fifteen studies (75%) reported potential benefits, primarily attributed to the capacity of prebiotic fibers to limit the growth or adhesion of bacteria. Only two studies (10%) reported an increase in pH. Overall, the quality of the evidence was judged as moderate. In conclusion, certain dietary fibers may help limit caries development by modulating biofilm and pH levels. However, further clinical studies are needed to confirm the protective role of dietary fibers in dental caries. © 2025 Society of Chemical Industry.