bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workplace violence against paramedic personnel: a protocol for a scoping review
Authors: Hokee Muhammad Yaaseen , Makkink Andrew William , Vincent-Lambert Craig 
Published: January 2023

IntroductionThere is evidence to suggest that violence against paramedic personnel is increasing. Several authors report adverse effects linked to exposure to workplace violence. There remain gaps in the knowledge related to specific aspects of workplace violence experienced by paramedics in the prehospital setting.Methods and analysisThis scoping review will consider evidence relating to workplace violence against paramedic personnel. All types of evidence will be considered, including quantitative and qualitative studies, systematic reviews, opinion papers, grey literature, text and papers as well as unpublished materials. This scoping review will be designed and conducted in accordance with the JBI methodology for scoping reviews. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews will guide the reporting process. Sources will include ERIC, Scopus, PubMed, CINAHL, Cochrane Library, ScienceDirect, Web of Science, Sabinet and the DOAJ as well as OpenGrey (https://opengrey.eu/). All sources published in English will be considered for inclusion and no date limit will be applied. The searching of the databases will begin 16 January 2023 and will be concluded by 30 January 2023. Three independent reviewers will conduct the study selection and data extraction process. In the event of disagreement related to a particular source, this will be resolved by discussion. The findings of the proposed review will be presented in a narrative style that uses diagrams and tables for reporting.Ethics and disseminationThis scoping review will use published literature available in the public domain and will involve no participants, meaning that ethical approval is not required. The findings of the proposed review will be published in topic relevant peer-reviewed journals and will be presented at associated conferences.
Exercise in patients with repaired tetralogy of Fallot: a systematic review and meta-analysis
Authors: Schuermans Art , Boerma Melissa , Sansoni Gabriela A , Van den Eynde Jef , Takkenberg Johanna J M , Helbing Willem A , Geva Tal , Moons Philip , Van De Bruaene Alexander , Budts Werner 
Published: January 2023

ObjectiveChildren and adults with repaired tetralogy of Fallot (rTOF) have an impaired exercise capacity, a less active lifestyle and an increased long-term risk of adverse outcomes compared with healthy peers. This study aimed to summarise the current evidence for the effectiveness and safety of exercise training interventions in patients with rTOF.MethodsPubMed/MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus and reference lists of relevant articles were searched for prospective studies published by November 2021. Random-effects meta-analysis and descriptive synthesis were performed to assess the effectiveness and safety of exercise training in patients with rTOF.ResultsOf the 9677 citations identified, 12 articles were included that reported on 10 unique studies and covered 208 patients with rTOF (range of mean/median age: 7.4–43.3 years). All studies implemented 2 to 7 aerobic or respiratory training sessions per week with durations ranging from 6 to 26 weeks. Meta-analysis of the included randomised controlled trials showed that exercise training was associated with a significant improvement in peak VO2(pooled mean difference: +3.1 mL/min/kg; 95% CI: 0.76 to 5.36 mL/min/kg, p=0.019). Cardiac imaging studies revealed no subclinical adverse remodelling after the exercise interventions. No serious adverse events including arrhythmias were reported in these studies.ConclusionCurrent evidence suggests that exercise training can improve exercise capacity in patients with rTOF with a low risk for adverse events. Exercise prescription may be a safe and effective tool to help improving outcomes in patients with rTOF.PROSPERO registration numberCRD42021292809.
Regularized limit, analytic continuation and finite-part integration
Authors: Galapon Eric A. 
Published: January 2023

Finite-part integration is a recent method of evaluating a convergent integral in terms of the finite-parts of divergent integrals deliberately induced from the convergent integral itself [E. A. Galapon, The problem of missing terms in term by term integration involving divergent integrals, Proc. R. Soc. A 473 (2017) 20160567]. Within the context of finite-part integration of the Stieltjes transform of functions with logarithmic growths at the origin, the relationship is established between the analytic continuation of the Mellin transform and the finite-part of the resulting divergent integral when the Mellin integral is extended beyond its strip of analyticity. It is settled that the analytic continuation and the finite-part integral coincide at the regular points of the analytic continuation. To establish the connection between the two at the isolated singularities of the analytic continuation, the concept of regularized limit is introduced to replace the usual concept of limit due to Cauchy when the later leads to a division by zero. It is then shown that the regularized limit of the analytic continuation at its isolated singularities equals the finite-part integrals at the singularities themselves. The treatment gives the exact evaluation of the Stieltjes transform in terms of finite-part integrals and yields the dominant asymptotic behavior of the transform for arbitrarily small values of the parameter in the presence of arbitrary logarithmic singularities at the origin.
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer
Authors: Qiu Hong , Makarov Vladimir , Bolzenius Jennifer K. , Halstead Angela , Parker Yvonne , Wang Allen , Iyer Gopakumar V. , Wise Hannah , Kim Daniel , Thayaparan Varna , Lindner Daniel J. , Haber Georges-Pascal , Ting Angela H. , Ren Bing , Chan Timothy A. , Arora Vivek , Solit David B. , Lee Byron H. 
Published: January 2023

AbstractDisruption of KDM6A, a histone lysine demethylase, is one of the most common somatic alternations in bladder cancer. Insights into how KDM6A mutations affect the epigenetic landscape to promote carcinogenesis could help reveal potential new treatment approaches. Here, we demonstrated that KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and induces a neoplastic state characterized by increased cell proliferation. In bladder cancer cells with intact KDM6A, FOXA1 interacted with KDM6A to activate genes instructing urothelial differentiation. KDM6A-deficient cells displayed simultaneous loss of FOXA1 target binding and genome-wide redistribution of the bZIP transcription factor ATF3, which in turn repressed FOXA1-target genes and activated cell-cycle progression genes. Importantly, ATF3 depletion reversed the cell proliferation phenotype induced by KDM6A deficiency. These data establish that KDM6A loss engenders an epigenetic state that drives tumor growth in an ATF3-dependent manner, creating a potentially targetable molecular vulnerability.Significance:A gain-of-function epigenetic switch that disrupts differentiation is triggered by inactivating KDM6A mutations in bladder cancer and can serve as a potential target for novel therapies.
Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction
Authors: Florian David C. , Bennett Natalie E. , Odziomek Mateusz , Baljon Jessalyn J. , Wehbe Mohamed , Merkel Alyssa R. , Fischer Melissa A. , Savona Michael R. , Rhoades Julie A. , Guelcher Scott A. , Wilson John T. 
Published: January 2023

When breast cancer metastasizes to bone, treatment options are limited. Failure to treat bone metastases is thought to be due to therapy-resistant features of the bone marrow microenvironment. Using a murine model of bone metastatic mammary carcinoma, we demonstrate that systemic delivery of polymer nanoparticles loaded with cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) inhibited tumor growth and bone destruction after 7 days of treatment. Each dose of STING-activating nanoparticles trafficked to the bone marrow compartment and was retained within the tumor microenvironment for over 24 hours, enhancing antitumor immunity through proinflammatory cytokine production and early T-cell activation. While acquired resistance mechanisms, including increased levels of immunosuppressive cytokines and the infiltration of regulatory T cells, ultimately limited antitumor efficacy after 2 weeks of treatment, bone protective effects remained. Overall, these studies demonstrate that STING pathway activation, here enabled using a nanomedicine approach to enhance CDN delivery to bone metastatic sites, can reprogram the immune contexture of the bone marrow to an antitumor phenotype that inhibits bone colonization of metastatic breast cancer cells and protects from tumor-mediated bone destruction.Significance:Bone metastases are difficult to treat due to the inaccessibility of the bone marrow compartment and the immunosuppressive microenvironment that protects resident stem cells. Packaging a STING agonist into a nanoparticle that enables systemic administration and drug accumulation at tumor sites overcomes both barriers to stymie metastatic breast cancer growth.
Gradual Modifications and Abrupt Replacements: Two Stochastic Lexical Ingredients of Language Evolution
Authors: Pasquini Michele , Serva Maurizio , Vergni Davide 
Published: January 2023

AbstractThe evolution of the vocabulary of a language is characterized by two different random processes: abrupt lexical replacements, when a complete new word emerges to represent a given concept (which was at the basis of the Swadesh foundation of glottochronology in the 1950s), and gradual lexical modifications that progressively alter words over the centuries, considered here in detail for the first time. The main discriminant between these two processes is their impact on cognacy within a family of languages or dialects, since the former modifies the subsets of cognate terms and the latter does not. The automated cognate detection, which is here performed following a new approach inspired by graph theory, is a key preliminary step that allows us to later measure the effects of the slow modification process. We test our dual approach on the family of Malagasy dialects using a cladistic analysis, which provides strong evidence that lexical replacements and gradual lexical modifications are two random processes that separately drive the evolution of languages.
Deep Permutation Design: A New Potential Artificial Intelligence-Based Design Methodology
Authors: Terzidis Kostas , Fabrocini Filippo , Lee Hyejin , Daumard Louis 
Published: January 2023

Abstract
An artificial intelligence-based design methodology is presented based on permutations and neural networks. Elements are combined in all possible ways to form all possible design solutions, and a neural network extracts the best solution after being trained on either objective or subjective criteria. This methodology is projected to have many applications in fashion, architecture, music, storytelling, cooking, or any other design or art field that can be represented as a set of permutations.
Headbobing behavior in the high mountain lizard Phymaturus palluma: effects of sex and context
Authors: Vicenzi Nadia , Vicente Natalin S. 
Published: January 2023

Abstract
Headbobbing represents one of the primary sources of communication in Iguanian lizards. Here, we describe and analyze for the first time the form and structure of the headbob display in a species of the Phymaturus genus, and compare it across sexes, social contexts, and with other species of its family. We video-recorded Phymaturus palluma adult lizards, obtained the form and structure of headbobs and evaluated the effect of sex and social context on their performing generalized linear mixed models. We found that in P. palluma, headbob is a complex display composed of several units. Headbob pattern is stereotyped, with less than 35% of variation between individuals, suggesting that it is species-specific. Moreover, units vary among sex and social context, revealing that this display is multicomponent and non-redundant following the multiple-message hypothesis. We also found that the headbob pattern was more complex than in other Liolaemidae lizards, which probably is related to the social systems registered in Phymaturus.
Cyberpragmatics: Complaints and the Collective Perspective
Authors: Olshtain Elite , Treger Idan 
Published: January 2023

Abstract
The aim of this article is to lay some groundwork for expanding the study of speech act pragmatics within the cyber-world. For this purpose, we have investigated complaints in Hebrew online, in an attempt to highlight features that distinguish online communication from face-to-face communication. We have analysed complaints in three major spheres: a) complaints towards public institutions, b) complaints against commercial firms and c) sharing complaints for the common benefit of a social community. In all instances, complainers online co-construct the context and the shared knowledge of the offence (complainable).
Like many other studies of online communication, we too found a tendency towards uncivil or aggressive expressions (Vladimirou et al., 2021) especially when there was no hope for “repair” of the situation (ex: these damned people lie to us (in Hebrew ‘arurim’)). Furthermore, there were individual complainers who used the online platform to gain social and political power presenting themselves as defenders of justice and of the well-being of the community.
Rockefeller Foundation Philanthropy and Modern Public Health in China and India
Authors: Longkumer Tiasangla 
Published: January 2023

Abstract
The Rockefeller Foundation (RF) was the first major American philanthropic organization to engage in public health issues in China and India. Since the early years of its inception, the RF has been very influential in the global development of public health, not only through its grant-making but also by participating in shaping concepts and policies. Science-based innovations with a biomedical focus have formed the basis of the foundation’s public health approach and there has always been an overt focus on technological solutions to social issues. This article explores the differences in the scope, nature, and depth of the engagement of the RF with health institutions and programmes in China and India in the early twentieth century. Drawing from archival resources and secondary literature, this article traces the RF’s historical development in China and India in depth, its philanthropic giving, its impact on knowledge construction, social policies, and the agenda it has sought to fulfil.
Moist Baroclinic Instability along the Subtropical Mei-Yu Front
Authors: Yang Guang , Li Tim 
Published: January 2023

Abstract
Differing from classic midlatitude dry baroclinic instability theory, atmospheric motions over the subtropical mei-yu front in boreal summer are dominated by synoptic-scale disturbances coupled with precipitation and moisture under a weaker background vertical shear. This moisture–precipitation–circulation interactive feature, along with a preferred zonal wavelength of about 3400 km and eastward phase propagation, is explained by a moist baroclinic instability theoretical framework. The new framework is an extension of a traditional two-level baroclinic model by considering a prognostic moisture equation, the moisture–precipitation–circulation feedback, and an interactive planetary boundary layer. An eigenvalue analysis of the model shows that the most unstable mode has a preferred zonal wavelength of 3400 km, a westward-tilted vertical structure, and a phase leading of maximum moisture and precipitation anomalies relative to a lower-tropospheric trough, all of which are in good agreement with observations. Both anomalous horizontal and vertical advection processes contribute to the moisture increase. Further sensitivity tests show that the instability and the zonal-scale selection primarily arise from the moisture–convection–circulation feedback, while the vertical shear provides an additional energy source for the perturbation growth. This moist baroclinic instability theory explains well the observed characteristics of the development of synoptic-scale disturbances along the mei-yu front.
Comparison of Perineal Closure Techniques after Abdominoperineal Resections for Carcinoma of the Anus
Authors: Cataneo Jose L. , Mathis Sydney A. , Faqihi Sabreen , Valle Diana D. del , Perez-Tamayo Alejandra M. , Mellgren Anders F. , Alkureishi Lee W. T. , GanttJr Gerald 
Published: January 2023

Background Perineal reconstruction following salvage APR’s for squamous cell carcinoma of the anus (SCCA) are scant with conflicting results from large and single center studies. We analyzed these techniques taking into account sociodemographic and oncologic variables. Methods This is a retrospective cohort study from 2016-2019 using a targeted ACS/NSQIP database stratified into primary closure (PC), abdominal myocutaneous (AM), lower extremity (LE), and omental pedicled (OP) flaps. We analyzed major and wound complications through univariate and multivariate regression analysis. Results A total of 766 patients were analyzed, 512 (67%) had PC, 196 (25%) AM, 36 (5%) OP and 22 (3%) LE. Rates of chemotherapy and radiation within 90 days were similar between the groups. Having 2 or more additional organs resected was more common for the AM group (AM 4.1%, PC 1.6%, OP 3.3%, LE 0%). Overall, major complication rate was 41% (n = 324). Primary closure had 35.0%, OP 47.2%, AM 52.6%, and LE 45.5%. Wound complication rate was highest in AM with 11.7%, followed by OP 8.3%, PC 5.9%, and LE 0%. The multivariate regression analysis demonstrated none of the closure techniques to be associated with increasing or decreasing the probability of having a major or wound complication. Morbidity probability was the sole predictor of major complication (OR 1.07, 95% CI 1.04-1.1) Conclusions Myocutaneous and omental flaps are associated with comparable wound and major complications when taking into account the baseline, oncologic and perioperative variables that drive the clinical decision making when selecting a perineal reconstruction.
Silver/reduced graphene oxide nanocomposite materials synthesized via a green molecular level mixing
Authors: Silvain Jean-François , Thomas Benjamin , Constantin Loic , Pontoreau Maël , Lu Yongfeng , Grosseau-Poussard Jean-Luc , Lacombe Guillaume 
Published: January 2023

The fabrication of nano reinforced metal matrix composites (MMCs) is scientifically essential to further upgrade the thermal, electrical, and mechanical properties of current MMCs. Here, we present a green molecular mixing (MLM) of silver (Ag) and graphene (G) to overcome these challenges. Experimental results show that the green MLM allows to homogeneously mix 3 vol. % of G as observed with traditional MLM while adding a control on the oxidation steps. Metal and GO reductions can be precisely control by varying the solution temperature. Highly thermal conductivity and strong elastic modulus nanocomposites are fabricated making it an eco-friendlier mixing process.
Development Projects, Models of Capitalism, and Political Regimes in Brazil, 1988–2021
Authors: Pinho Carlos Eduardo Santos 
Published: January 2023

The Bolsonaro government combines authoritarianism with a model of capitalism that destroys social rights. Despite the expansion of the neoliberal reforms put in place during the 1990s and the decline of the inclusionary policies of the 2000s, there is a causal link between the content of neoliberal public policies, the drop in the level of political participation in their implementation, the militarization of the Bolsonaro government, and the decay of democratic institutions in Brazil. O governo Bolsonaro combina o autoritarismo com um modelo de capitalismo destruidor de direitos sociais. Além do aprofundamento das reformas neoliberais dos anos 1990 e da regressão das políticas de inclusão dos anos 2000, há uma relação de causalidade entre o conteúdo de políticas públicas neoliberais, a redução do nível de participação política em sua implementação, a militarização do governo Bolsonaro e a degeneração de instituições democráticas no Brasil.
Learning About the Incidence and Lethality of COVID-19 in Vulnerable Neighborhoods: The Case of Malaga (Spain)
Authors: García-Peña Carmen , Molina Julián , Ruiz Sinoga José Damián 
Published: January 2023

This research delves into the need to use granular analyses at the neighborhood level to study the preexisting conditions of vulnerability that best explain the waves of COVID-19 incidence and mortality. It seems most appropriate to use the comprehensive approach of the sustainable development with variables that analyze the economic, social, environmental, and governance dimensions, given the extensive literature that identifies each as a determining factor for the impact of disease. The work utilizes a composite vulnerability index that allows the city of Malaga to be divided into 434 census sections; waves of incidence and mortality for each section are constructed for the period of March 2020 to March 2021. Cluster analysis reveals that there are five different cluster incidence patterns, whereas the lethality waves are found to behave as a hot-spot phenomenon. The results reveal that neighborhoods that are the most vulnerable in terms of their demographic conditions (large proportion over 65 years of age and dependent) and socioeconomic conditions (severe material deprivation), have been the most affected by COVID-19 infection and mortality.
Validation of the slaughterhouse porcine heart model for ex-situ heart perfusion studies
Authors: Kaffka genaamd Dengler Selma E , Mishra Mudit , van Tuijl Sjoerd , de Jager Saskia CA , Sluijter Joost PG , Doevendans Pieter A , van der Kaaij Niels P 
Published: January 2023

Introduction To validate slaughterhouse hearts for ex-situ heart perfusion studies, we compared cold oxygenated machine perfusion in less expensive porcine slaughterhouse hearts ( N = 7) to porcine hearts that are harvested following the golden standard in laboratory animals ( N = 6). Methods All hearts received modified St Thomas 2 crystalloid cardioplegia prior to 4 hours of cold oxygenated machine perfusion. Hearts were perfused with homemade modified Steen heart solution with a perfusion pressure of 20–25 mmHg to achieve a coronary flow between 100–200 mL/min. Reperfusion and testing was performed for 4 hours on a normothermic, oxygenated diluted whole blood loaded heart model. Survival was defined by a cardiac output above 3 L with a mean aortic pressure above 60 mmHg. Results Both groups showed 100% functional survival, with laboratory hearts displaying superior cardiac function. Both groups showed similar decline in function over time. Conclusion We conclude that the slaughterhouse heart can be used as an alternative to laboratory hearts and provides a cost-effective method for future ex-situ heart perfusion studies.