bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Biological Collections Data through Human-AI Collaboration
Authors: Stenhouse Alan , Fisher Nicole , Lepschi Brendan , Schmidt-Lebuhn Alexander , Rodriguez Juanita , Turco Federica , Toms Emma , Reeson Andrew , Paris Cécile , Thrall Pete 
Published: September 2023

Biological collections play a crucial role in our understanding of biodiversity and inform research in areas such as biosecurity, conservation, human health and climate change. In recent years, the digitisation of biological specimen collections has emerged as a vital mechanism for preserving and facilitating access to these invaluable scientific datasets. However, the growing volume of specimens and associated data presents significant challenges for curation and data management. By leveraging human-Artificial Intelligence (AI) collaborations, we aim to transform the way biological collections are curated and managed, unlocking their full potential in addressing global challenges.
We present our initial contribution to this field through the development of a software prototype to improve metadata extraction from digital specimen images in biological collections. The prototype provides an easy-to-use platform for collaborating with web-based AI services, such as Google Vision and OpenAI Generative Pre-trained Transformer (GPT) Large Language Models (LLM). We demonstrate its effectiveness when applied to herbarium and insect specimen images. Machine-human collaboration may occur at various points within the workflows and can significantly affect outcomes. Initial trials suggest that the visual display of AI model uncertainty could be useful during expert data curation. While much work remains to be done, our results indicate that collaboration between humans and AI models can significantly improve the digitisation rate of biological specimens and thereby enable faster global access to this vital data.
Finally, we introduce our broader vision for improving biological collection curation and management using human-AI collaborative methods. We explore the rationale behind this approach and the potential benefits of adding AI-based assistants to collection teams. We also examine future possibilities and the concept of creating 'digital colleagues' for seamless collaboration between human and digital curators. This ‘collaborative intelligence’ will enable us to make better use of both human and machine capabilities to achieve the goal of unlocking and improving our use of these vital biodiversity data to tackle real-world problems.
Éthiques inclusives en éducation
Authors: Tremblay Philippe 
Published: September 2023

Dans le cadre de cet article, les trois fondements de l’École inclusive (politique, scientifique et pédagogique) (Tremblay, 2012) seront présentés puis analysés en s’appuyant sur les trois principales théories qui encadrent l’éthique normative : 1- le déontologisme (appréciation, a priori, de certains actes comme étant moralement requis et d’autres comme étant moralement prohibés), 2- le conséquentialisme (appréciation de la moralité d’un acte en fonction de ses conséquences sur le bien-être général) et 3) le vertuisme (appréciation de l’épaisseur morale des agents, au-delà des actes posés) (Prairat, 2015 ; Lewin, 2014). Cette analyse contextualisée sur la base des forces, faiblesses et limites de ces fondements permettra de dessiner et de discuter les contours d’une éthique pour les enseignantes et enseignants engagés dans la construction et le développement d’une École inclusive.
Sciences du danger et éthique des organisations : une approche à développer !
Authors: Joras Michel 
Published: September 2023

Par la globalisation en cours s’esquisse une économie monde que l’on pourrait représenter autour de trois repères, marqueurs de transformation, de mutation, si ce n’est de métamorphose : - une prise de conscience émergente par nombre de gouvernants et de dirigeants de l’importance de leur responsabilité sociétale (RSE) ; - une exigence de « comportements et pratiques éthiques » de tous les Agents ; - une préoccupation vitale pour la pérennité de leurs organisations d’appréhender la prévention de la réalisation du danger par des politiques de pilotage et de gestion des risques en « sécurité globale ». Après avoir répondu au double questionnement : « de quoi les sciences du danger sont-elles la chose ? » et « de quoi une éthique des organisations est-elle le nom ? », sera explicité le lien entre les concepts des cindyniques, sciences du danger, et la notion managériale de « sûreté éthique ». Enfin sera dressé un cadre pour une opérationnalité, et des moyens à diligenter pour satisfaire une « sûreté éthique » raisonnable. Pour conclure sera soulignée l’ardente nécessité de promouvoir, tant dans l’enseignement supérieur qu’au sein des organisations, la maîtrise des dangers, la responsabilité sociétale et l’éthique appliquée aux organisations.
Monetary Policy with Weakened Unions
Authors: Barbier-Gauchard Amélie , Betti Thierry , De Palma Francesco 
Published: September 2023

Nous évaluons l’impact du pouvoir de négociation des syndicats sur l’inflation et l’emploi dans le cadre d’un modèle de contrat optimal à la Mac Donald & Solow [1981]. Nous considérons un jeu à la Stackelberg entre la banque centrale et les partenaires sociaux (entreprises et syndicats). Les entreprises et les syndicats négocient l’emploi et le salaire nominal, tandis que la banque centrale, qui joue le rôle de leader , fixe le taux d’inflation. Nous montrons qu’une diminution du pouvoir de négociation des syndicats tend à réduire le salaire nominal et l’emploi. Dans un tel contexte de banque centrale leader , la politique monétaire optimale consiste à augmenter le taux d’inflation optimal afin d’éviter une hausse du chômage. De plus, nous démontrons que l’augmentation du taux d’inflation optimal a des effets plus importants lorsque la banque centrale est faiblement conservatrice. Ces résultats plaident en faveur d’une réduction du conservatisme de la banque centrale pour compenser l’impact macroéconomique de la baisse du pouvoir de négociation des syndicats. Classification JEL : E02, E24, E52, E58, J51
Foliar application of silicon has little effect on hydroponically grown barley (Hordeum vulgare L.) / Foliarno dodajanje silicija ima malo učinka na hidroponsko gojen ječmen (Hordeum vulgare L.)
Authors: Mavrič Čermelj Anja , Golob Aleksandra , Kacjan Maršić Nina , Germ Mateja 
Published: September 2023

Silicon is an element widely distributed on the earth’s crust. It can ameliorate stress in plants grown in unfavorable conditions. Barley is an important cereal used as a staple food. In our experiment, barley was grown on a floating hydroponics system in a greenhouse. Plants were stabilized in pots containing rockwool. Half of the plants were sprayed with potassium silicate (0.25 ml 6% K2SiO3 L-1) every ten days for 35 days. The vitality of plants during their growth was monitored by measuring the potential photochemical efficiency of photosystem II. After 16 and 35 days of silicon application, shoot length, root length, and fresh and dry biomass were measured. At the end of the experiment, the number of leaves and shoots, specific leaf area, leaf optical properties, and lipid peroxidation were determined as well. The potential photochemical efficiency of photosystem II was close to 0.8 and unaffected by the addition of silicon, indicating a good condition of the plants. Results showed lower leaf reflectance for silicon-treated plants in UVA, UVB, and blue light wavelengths, possibly due to a layer of potassium silicate on leaves. After 16 days, silicon-treated plants’ fresh shoot weight and root length were higher than in control plants. Results showed that additional foliar application of silicon does not cause stress in the barley plant.

Izvleček
Silicij je pogost element v zemljini skorji in lahko znižuje stres rastlin, ki rastejo v neugodnih razmerah. Ječmen je za ljudi pomembno žito, saj spada med osnovna živila. Poskus smo izvedli na plavajočem hidroponskem sistemu v rastlinjaku na Biotehniški fakulteti. Rastline so bile ukoreninjene v lončkih s kameno volno. Polovico rastlin smo škropili s kalijevim silikatom (0,25 ml 6% K2SiO3 L-1) vsakih deset dni. Med rastjo smo spremljali vitalnost rastlin z merjenjem potencialne fotokemične učinkovitosti fotosistema II. Po 16 in 35 dneh nanašanja Si, smo izmerili velikost poganjkov, dolžino korenin ter svežo in suho biomaso. Na koncu poskusa smo prešteli število listov in poganjkov, določili specifično listno površino, optične lastnosti listov in stopnjo lipidne peroksidacije. Potencialna fotokemična učinkovitost fotosistema II je bila v vseh tretmajih blizu 0,8, kar je nakazovalo na dobro stanje rastlin. Rezultati so pokazali nižjo odbojnost listov pri rastlinah, škropljenih s Si v UVA, UVB in modrem spektru valovnih dolžin, najverjetneje zaradi nastale plasti kalijevega silikata na listih. Po 16 dneh so imele s Si tretirane rastline večjo svežo maso poganjkov in daljše korenine kot rastline brez dodanega Si. Rezultati so pokazali, da škropljenje s silicijem ne povzroča stresa v ječmenu.
Inscrire des communautés morales en Bourgogne durant l’Antiquité tardive : valeurs anciennes, significations polyvalentes et nouvelles perspectives de recherche – version abrégée
Authors: Grose Becca 
Published: September 2023

Le contenu textuel des inscriptions de la Gaule de l’Antiquité tardive a souvent été négligé à la faveur de leur contenu « factuel ». Ce chapitre présente les avantages de l’étude de ces épitaphes en tant que textes utilisant des stratégies visuelles et littéraires. À cet effet, il met l’accent sur un aspect de ces textes en particulier : le langage moral.Premièrement, l’utilisation de recueils de formules types dans l’épigraphie de Gaule romaine de l’Antiquité tardive est abordée. Tandis que les preuves pour leur existence sont limitées, des modèles dans la distribution des épithètes moraux laissent supposer la présence d’un recueil de formules types activement entretenu. Cela indique l’importance d’un langage moral correct plutôt qu’une passivité et un illettrisme.Deuxièmement, la façon dont la même valeur morale, caritas, a été positionnée différemment sur différentes épitaphes est examinée afin de souligner l’importance de valences différentes. En changeant l’emplacement physique et syntaxique du mot et en utilisant des mots apparentés, les auteurs des inscriptions ont utilisé des valeurs communes afin de raconter des histoires différentes.
Un dispositif singulier de l’Antiquité tardive à la chapelle Saint-Jean-de-Todon (Laudun-l’Ardoise, Gard, France)
Authors: Ardagna Yann , Rigeade Catherine , Forest Vianney , Seguin Maxime , Vidal Laurent 
Published: September 2023

De 2002 à 2012 une fouille programmée a été menée autour de la chapelle « Saint-Jean-de-Rousigue » (Laudun-l’Ardoise, Gard) que les sources archivistiques identifient à l’église prieurale de Saint-Jean-de-Todon. Cette dernière est implantée sur une partie d’un vaste plateau calcaire surplombant la vallée du Rhône comprenant une agglomération protohistorique et romaine nommée sur le plan cadastral « Camp de César ». L’édifice cultuel est situé à 380 m au nord d’un ensemble d’édifices publics antiques (forum/basilique, enceinte) occupés jusqu’au vie s. ou début viie s. Un bâtiment et une aire funéraire singulière, datés de l’Antiquité tardive, ont été découverts au sud et au nord de la chapelle. Ce type de structures archéologiques, que ce soit pour le mode de construction du bâti ou pour l’agencement des restes humains et fauniques présents, paraissent ne pas trouver d’équivalent dans la littérature régionale. Les quatre datations 14C réalisées ont permis de restituer la mise en place de ce dépôt et de la tombe entre le iiie et ve siècles après J.-C. De plus ce dépôt original se situe à proximité d’une tombe monumentale, contemporaine, renfermant un sujet adulte et deux sujets immatures
The funerary area of the 5th and 6th c. CE of Saint-Martin-le-Bas at Gruissan (Aude, France)
Authors: Granier Gaëlle , Sperandio Emeline , Duperron Guillaume 
Published: September 2023

Located near Narbonne, the coastal settlement of Saint-Martin-le-Bas in Gruissan was very active during Late Antiquity. Although the habitat of this period remains to be studied, a funerary area associated with this occupation is located on a small relief dominating the coastline. Its exhaustive excavation has revealed 39 funerary structures which are divided into 4 phases of occupation, from the end of the 3rd century to the 13th century. The first burials took place after the abandonment of the buildings of the Early Empire, at the end of the 3rd or in the 4th century. Then, probably in the 5th or 6th century, burials of an exceptional nature were set up in a funerary building. A desire to gather these tombs around the first sarcophagus seems to be at the origin of the development of the southern funerary area of the 5th and 6th centuries. The data provided by the study of this funerary complex contributes to the ongoing reflection on the status of this late antique site.
L’ensemble funéraire des ve et vie s. de n. è. de Saint-Martin-le-Bas à Gruissan (Aude, France)
Authors: Granier Gaëlle , Sperandio Emeline , Duperron Guillaume 
Published: September 2023

Situé près de Narbonne, l’établissement littoral de Saint-Martin-le-Bas à Gruissan, connaît durant l’Antiquité tardive une activité importante. Si l’habitat de cette période reste à étudier, un secteur funéraire associé à cette occupation est localisé sur un petit relief dominant le littoral. Sa fouille exhaustive a révélé 39 structures funéraires qui se répartissent dans 4 phases d’occupation, allant de la fin du iiie s. jusqu’au xiiie s. Les premières sépultures s’installent, après l’abandon des bâtiments du Haut-Empire, à la fin du iiie ou au ive s. Puis, vraisemblablement au ve s. ou au vie s., des sépultures à caractère exceptionnel sont mises en place, dans un probable édifice funéraire. Une volonté de rassemblement de ces tombes autour du premier sarcophage semble à l’origine du développement de l’aire funéraire méridionale des ve et vie s. Les données livrées par l’étude de cet ensemble funéraire contribuent à la réflexion en cours sur le statut de ce site tardo-antique.
CD160 Signaling Is Essential for CD8+ T Cell Memory Formation via Upregulation of 4-1BB
Authors: Zhang Linxia , Zhang Anli , Zhu Xinyu , Tian Xinmei , Guo Jiaohan , He Qian , Zhu Lingyan , Yuan Songhua , Zhao Chen , Zhang Xiaoyan , Xu Jianqing 
Published: September 2023

Abstract
A better understanding of the regulatory mechanisms governing the development of memory CD8+ T cells could provide instructive insights into vaccination strategies and T cell–based immunotherapies. In this article, we showed that CD160 surface protein is required for CD8+ T cell memory formation. In the response to acute lymphocytic choriomeningitis virus infection in a mouse model, CD160 ablation resulted in the failure of the development of all three memory CD8+ T cell subsets (central, effective, and tissue-resident memory), concomitant with a skewed differentiation into short-lived effector T cells. Such memory-related defect was manifested by a diminished protection from viral rechallenge. Mechanistically, CD160 deficiency led to downregulation of 4-1BB in activated CD8+ T cells, which contributes to the impaired cell survival and decreased respiratory capacity. The nexus between CD160 and 4-1BB was substantiated by the observation that ectopic introduction of 4-1BB was able to largely complement the loss of CD160 in memory CD8+ T cell development. Collectively, our studies discovered that CD160, once thought to be a coinhibitor of T cell signaling, is an essential promoter of memory CD8+ T cell development via activation of the costimulatory molecule 4-1BB.
Genome-Wide CRISPR/Cas9 Screening Identifies That Mitochondrial Solute Carrier SLC25A23 Attenuates Type I IFN Antiviral Immunity via Interfering with MAVS Aggregation
Authors: Zhang Hongguang , Li Xin , Wang Yiwei , Liu Xianxian , Guo Jing , Wang Zheng , Zhang Lulu , Xiong Sidong , Dong Chunsheng 
Published: September 2023

Abstract
Activation of the mitochondrial antiviral signaling (MAVS) adaptor, also known as IPS-1, VISA, or Cardif, is crucial for antiviral immunity in retinoic acid–inducible gene I (RIG-I)–like receptor signaling. Upon interacting with RIG-I, MAVS undergoes K63-linked polyubiquitination by the E3 ligase Trim31, and subsequently aggregates to activate downstream signaling effectors. However, the molecular mechanisms that modulate MAVS activation are not yet fully understood. In this study, the mitochondrial solute carrier SLC25A23 was found to attenuate type I IFN antiviral immunity using genome-wide CRISPR/Cas9 screening. SLC25A23 interacts with Trim31, interfering with its binding of Trim31 to MAVS. Indeed, SLC25A23 downregulation was found to increase K63-linked polyubiquitination and subsequent aggregation of MAVS, which promoted type I IFN production upon RNA virus infection. Consistently, mice with SLC25A23 knockdown were more resistant to RNA virus infection in vivo. These findings establish SLC25A23 as a novel regulator of MAVS posttranslational modifications and of type I antiviral immunity.
Fracture of the mandible treatment in a child: a simplified technique
Authors: Houben Christoph H. , Campbell Lundy , Chiok Stephen Kuol Chuol 
Published: September 2023

After being hit by a motorcycle a seven-year old boy presented with a displaced fracture of the body of the right mandible [type III]. In the absence of orthodontic internal fixation or ligature wire equipment suture material was used to provide approximation and stabilisation of the fracture. The non-absorbable suture was fed through a cannula which was pierced through the bone on either side of the fracture.
We present this simplified technique as a suitable alternative for the fixation of mandible fractures in settings with very limited resources.
Jujuboside a Improved Energy Metabolism in Senescent H9c2 Cells Injured by Ischemia, Hypoxia, and Reperfusion through the CD38/Silent Mating Type Information Regulation 2 Homolog 3 Signaling Pathway
Authors: Hu Yi-Ran , Qu Hui-Yan , Guo Jia-Ying , Yang Tao , Zhou Hua 
Published: September 2023

Objective:
This study explored the myocardial protection role of Jujuboside A through an ischemia–hypoxia–reperfusion (IHR) model.

Materials and Methods:
H9c2 cells were induced by D-galactose (D-gal) and IHR to establish an aging and IHR model. There are four groups of experiments: Control, IHR, D-gal + IHR, and D-gal + IHR + Jujuboside A. Cells viability, Adenosine triphosphate (ATP), reactive oxygen species (ROS), nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide hydride (NADH) content, and NAD+/NADH ratio were detected using biochemical methods. Inflammatory cytokines level was detected by enzyme-linked immunosorbent assay. The expression of CD38, Recombinant NLR Family, pyrin domain-containing protein 3 (NLRP3), and silent mating type information regulation 2 homolog 3 (SIRT3) protein was detected by Western blotting.

Results:
Compared to the IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and SIRT3 protein expression decreased, ROS level and inflammatory cytokines increased, and CD38 and NLRP3 proteins raised in the D-gal + IHR group. Compared to the D-gal + IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and expression of SIRT3 protein increased, ROS level and inflammatory cytokines level decreased, and expression of the CD38 and NLRP3 proteins decreased in the D-gal + IHR + Jujuboside A group.

Conclusions:
Jujuboside A inhibited the expression of CD38, improved energy metabolism disorder, and mitochondrial function, and decreased inflammation in D-gal-induced H9c2 cells.
The Mechanism of Total Ginseng Extracts in the Treatment of Lung Cancer Progression Based on Network Pharmacology and Experimental Validation
Authors: Hana Hong-Kuan , Qian Cheng , Song Meng-Yao , Zhang Teng , Yang Chun-Mei , Gu Ren-Jun , Zhou Xian , Wei Zhong-Hong , Zhao Yang , Lu Yin 
Published: September 2023

Objective:
The objective of this study was to investigate the mechanism by which total ginseng extract (TGE) inhibits the progression of lung cancer through network pharmacology and experimentation.

Materials and Methods:
A Lewis lung carcinomas (LLC) model was established by injecting cancer cells through the tail vein and through administering different doses of TGE. The infiltrated immune cells into the microenvironment of lung cancer metastasis through flow cytometry were evaluated, and the messenger RNA (mRNA) expression levels of various immune cell-related chemokines were determined using quantitative reverse transcription–polymerase chain reaction. Therapeutic targets and signaling pathways of TGE in nonsmall cell lung cancer were investigated using systematic pharmacology and virtual docking. Immunoblotting was performed to determine the impacts of TGE on migration-related proteins.

Results:
Flow cytometry showed that 1.82 g/kg TGE increased the infiltrated T cells and inhibited the recruitment of myeloid cells, which was caused by decreased mRNA expression of chemokines after TGE treatment. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that the delayed progression of lung cancer by TGE might be related to the promotion of lung cancer cell apoptosis-associated signaling pathways. The virtual docking results indicated that the active components of ginseng are directly bound to apoptosis-related proteins. Immunoblotting showed that TGE inhibited tumor metastasis by regulating the expression of migration-related proteins.

Conclusions:
The study reveals the potential mechanism of ginseng extract in the treatment of lung cancer progression and provides a reliable basis for its clinical application.
A Case Series of Scrub Meningoencephalitis from a Tertiary Care Center in North India
Authors: Suri Vikas , Singh Harpreet , Ary Kunwer A. , Biswal Manisha , Ahuja Chirag K. , Kharbanda Parampreet , Sharma Navneet 
Published: September 2023

Abstract
Scrub typhus infection is reemerging leading cause of acute febrile illnesses in post-rainy or monsoon season in Southeast Asia. It is caused by Orientia tsutsugamushi and spread by the bite of chiggers, larval forms of trombiculid mites. The clinical picture can range from simple acute febrile illness to multiorgan dysfunction. Neurological manifestations also vary from aseptic meningitis, meningoencephalitis, cerebral infarction, acute disseminated encephalomyelitis, transverse myelitis, and psychiatric manifestations. Here, we present a case series of eight cases of scrub meningoencephalitis diagnosed based on clinical, laboratory, and radiological criteria.