bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized,Double-blind, Placebo-controlled, Multi-centric, Interventional, Prospective Clinical Study to Evaluate Efficacy and Safety of Passiflora incarnata (Aerial Parts) Extract in participants with Stress and Insomnia
Authors: Harit Mahesh Kumar , Mundhe Narendra , Tamoli Sanjay , Pawar Vinay , Bhapkar Vedvati , Mahadik Swapnali , Kulkarni Anand 
Published: May 2023

Abstract
Background: Passiflora incarnata is used for treating anxiety or nervousness, generalized anxiety disorder (GAD), insomnia, and other related disorders. Previous studies indicate that passion flower has a positive effect on sleep patterns. It reduces the time to fall asleep and increases the duration of sleep.
Objectives: To Evaluate Efficacy and Safety of Passiflora incarnata (Passion Flower) Extract in participants with Stress and Insomnia
Methods: In a Randomized, Double Blind, Placebo Controlled, Multi-centre, Interventional, Prospective Clinical Study, a total of 65 participants with stress and insomnia were screened and recruited and randomised to two groups (32 in the Passiflora group and 33 in the Placebo group). The participants were randomized either to Passiflora incarnata (Aerial Parts) Extract group or placebo group in 1:1 ratio. Subjects were asked to take given product at bed time with water for 30 days. Subjects were evaluated on Day 1, Day 15 and Day 30 on Perceived Stress Scale (PSS), subject’s Quality of Life on GHQ12 Scale. Subject’s insomnia was evaluated on Insomnia Severity Index. Appropriate statistical tests were applied to the data derived from the clinical study to draw inferences.
Results: Statistically significant reduction in mean score of stress on PSS and mean score of total sleep time were observed with the use of Passoflora extract as compared to placebo. The general psychological health significantly improved in Passiflora group compared to placebo group on day 15 and day 30. Passiflora Extract was found to be safe without producing any adverse effects.
Conclusion: Passiflora incarnata(aerial parts) extract was significantly effective in reducing stress and other related symptoms. It improved sleep time and quality of sleep with no adverse events.
Protective effects of phosphocreatine on human vascular endothelial cells against hydrogen peroxide-induced apoptosis and in the hyperlipidemic rat model
Authors: Tang Zhongyuan , Zhang Zonghui , Wang Jiaqi , Sun Zhengwu , Qaed Eskandar , Chi Xinming , Wang Jun , Jamalat Yazeed , Geng Zhaohong , Tang Zeyao , Yao Qiying 
Published: May 2023

Abstract
Phosphocreatine (PCr) has been shown to have a cardio-protective effect during cardiopulmonary resuscitation (CPR). However, little is known about its impact on atherosclerosis. In this study, we firstly evaluated the pharmacological effects of PCr on antioxidative defenses and mitochondrial protection against hydrogen peroxide (H2O2) induced human umbilical vascular endothelial cells (HUVECs) damage. Then we investigated the hypolipidemic and antioxidative effects of PCr on hyperlipidemic rat model. Via in vitro studies, H2O2 significantly reduced cell viability and increased apoptosis rate of HUVECs, while pretreatment with PCr abolished its apoptotic effect. PCr could reduce the generation of ROS induced by H2O2. Moreover, PCr could increase the activity of SOD and the content of NO, as well as decrease the activity of LDH and the content of MDA. PCr could also antagonize H2O2-induced up-regulation of Bax, cleaved-caspase3, cleaved-caspase9, and H2O2-induced down-regulation of Bcl-2 and p-Akt/Akt ratio. In addition, PCr reduced U937 cells’ adhesion to H2O2-stimulated HUVECs. Via in vivo study, PCr could decrease MDA, TC, TG and LDL-C levels in hyperlipidemic rats. Finally, different-concentration PCr could increase the leaching of TC, HDL, and TG from fresh human atherosclerotic plaques. In conclusion, PCr could suppress H2O2-induced apoptosis in HUVECs and reduce hyperlipidemia through inhibiting ROS generation and modulating dysfunctional mitochondrial system, which might be an effective new therapeutic strategy to further prevent atherosclerosis.
Deri ikamesi için gözenekli bakteriyel selüloz üretimi ve karakterizasyonu
Authors: İLMENÖZ Doruk , KESKİN Zalike , HAMEŞ TUNA Elif Esin 
Published: May 2023

Bakteriyel selüloz (BS), biyouyumlu, üretimi kolay, yüksek çekme dayanımı gösteren, nanofibril ağ yapısı ile yüksek su tutma özelliğinde olan ve bazı mikroorganizmalar tarafından üretilebilen doğal bir polimerdir. Medikal uygulamalar için iyi bir aday olan BS, membran yapısı nedeniyle deri ikamesi çalışmalarında geliştirilebilir bir potansiyel taşımaktadır. Ancak, sıkı yapıdaki selüloz nanofibrilleri hücre tutunması ve göçüne imkân vermemektedir. Bu çalışma kapsamında deri ikamesi olarak kullanılabilecek yeterli gözenek çapına sahip BS’nin in situ üretimi, keratin ile modifikasyonu ve karakterizasyonu amaçlanmıştır.
Gluconacetobacter xylinus ATCC 700178 suşu kullanılarak iki farklı yöntemle (agar parçalama ve agar damlatma) selüloz nanofibrilleri arasındaki gözenek çapı arttırılarak üretilen BS daha sonra derinin önemli bir bileşeni olan keratin ile modifiye edilmiştir. Keratin kaynağı olarak insan saçları kullanılmış ve Shindai özütlemesi ile keratin elde edilmiştir. Keratin çözeltisi BS membranlara emdirilerek malzemenin karakterizasyonu FTIR (Fourier dönüşümlü kızıl ötesi spektrometresi), SEM (Taramalı elektron mikroskobu) ve mekanik çekme dayanımı testleri ile gerçekleştirilmiştir. Sonuç olarak, arttırılmış gözenek çapına sahip (>100μm) yapısında keratin bulunduran ve 0,1- 0,15 MPa aralığında maksimum çekme dayanımı gösteren, deri ikame adayı olabilecek BS üretimi gerçekleştirilmiştir.
Ağır Vasıtalarda Otomatikleştirilmiş Manuel Şanzımana Ait Parametrelerin K-Means Algoritması Kullanılarak Optimizasyonu ve Yakıt Tüketimine Etkilerinin İncelenmesi
Authors: GÖÇER Duran Arif , YILDIZ İbrahim 
Published: May 2023

Şanzıman, motordan aldığı torku aracın tekerleklerine ileten güç aktarım organlarından kritik öneme sahip olan bir mekanizmadır. Araçlarda ise şanzıman tipine göre yakıt tüketimi farklılık göstermektedir. Yakıt ekonomisini iyileştirmek, emisyonu azaltmak ve sürüş performansını artırmak için son yıllarda şanzıman alanında birçok çalışmalar yapılmış olup araçlar üzerinde uygulanmıştır. Günümüzde birçok şanzıman çeşidi olmasına rağmen yaygın olarak kullanılan manuel ve otomatik şanzımanlardır. Bu şanzıman tiplerinin birbirine göre avantaj ve dezavantajları bulunmakta olup farklılıklar göz önünde bulundurularak yeni bir şanzıman arayışı ortaya çıkmıştır.
Çalışmada manuel ve otomatik şanzımanın özellikleri birleştirilerek vites değiştirme bileşenleri ile robotize(otomatikleştirilmiş manuel) şanzıman geliştirilmiştir. Manuel şanzıman sistemine entegre edilen vites değiştirme bileşenleri şanzımanın otomatikleştirilmesinde kullanılmıştır. Robotize hale getirilen otomatikleştirilmiş manuel şanzıman için kontrolü sağlanacak vites değişim parametreleri belirlenmiştir. Vites değiştirme parametrelerine ait optimum değerlerin bulunması için araç üzeri test çalışmaları yapılarak dinamik test sürüşleri gerçekleştirilmiştir. Bilindiği üzere manuel şanzımanlar otomatik şanzımanlardan daha verimli olmasına rağmen otomatik şanzımanda vites değişimi sürücüye bırakılmaksızın vites değişim parametrelerine göre otomatik olarak değişmektedir. Yapılan çalışmada ise vites değişimi sürücüden bağımsız halde bir vites değiştirme algoritmasına bağlı olarak kontrol edilmiştir. Sürücü ve vites değiştirme algoritması kontrolüne bağlı olarak yakıt tüketimleri dinamik test sürüşü ile ölçülmüştür.
K-means algoritması kullanılarak optimum vites değiştirme parametrelerine ait değer aralıkları belirlenmiştir. Optimum vites değiştirme parametrelerine göre araç ortalama 6,79 L/100km yakıt tüketmiştir. Sürücü algoritmadan bağımsız şekilde aracı kullanması sonucu ortalama 8,62 L/100km yakıt tükettiği gözlemlenmiştir. Vites değiştirme parametrelerinin optimize edilmesi ile %27 oranında yakıt tasarrufu sağlanmıştır.
Role of lncRNAs and circRNAs in Orofacial Clefts
Authors: Seelan Ratnam S. , Greene Robert M. , Pisano M. Michele 
Published: May 2023

Abstract:
Different modes of gene regulation, such as histone modification, transcription factor binding, DNA methylation, and microRNA (miRNA) expression, are critical for the spatiotemporal expression of genes in developing orofacial tissues. Aberrant regulation in any of these modes may contribute to orofacial defects. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and circular RNAs (circRNAs), have been shown to alter miRNA expression, and are thus emerging as novel contributors to gene regulation. Some of these appear to function as ‘miRNA sponges’, there-by diminishing the availability of these miRNAs to inhibit the expression of target genes. Such ncRNAs are also termed competitive endogenous RNAs (ceRNAs). Here, we examine emerging data that shed light on how lncRNAs and circRNAs may alter miRNA regulation, thus affecting orofacial development and potentially contributing to orofacial clefting.
Assessment of the Influence of the Regions of the Arctic Zone of the Russian Federation on the Economic Security of the State
Authors: Tsiklauri V. Yu. , Afanasyeva L. V. , Brusentseva J. A. 
Published: May 2023

Relevance. The Arctic zone of the Russian Federation is of great importance for the state. Russian activities in the Arctic are extremely open. Russia does not violate international obligations, protects national interests, solves the tasks of protecting and protecting the state border of the Russian Federation, protecting deposits, the unimpeded functioning of the Northern Sea Route, contributes to maintaining the balance of power in the region, counteracts, together with law enforcement agencies and special services, new challenges and threats to economic security. Strengthening economic security is facilitated by the implementation of the state program for the accelerated socioeconomic development of the Arctic zone, the achievement of strategic interests and ensuring national security.The purpose of the study is to assess the main socio-economic indicators of the regions of the Arctic zone of the Russian Federation and their impact on the economic security of the stateThe objectives of the study were: to study the directions of socio-economic development of the Arctic zone of the Russian Federation; analysis and evaluation of socio-economic indicators of the regions: GRP, fixed assets, investments in fixed capital, industrial production index; assessment of the effectiveness of the human capital of the regions; assessment of the effectiveness of the introduction and use of modern technologies; generalization of threats and risks.Methodology. The research methodology is based on general scientific methods, comparative analysis. The sources were scientific works of scientists-specialists in the field of ensuring economic security, regulatory and information materials of Rosstat, documents of a strategic nature.Results. The main result of the study was an assessment of the impact of the Arctic zone of the Russian Federation on the economic development of the state. Conclusions. The Arctic zone is an important and integral part of the socio-economic system of the Russian Federation. It allows to ensure the stability of the economy by creating conditions for employment of the population, ensures high labor productivity, promotes the development of innovations in entrepreneurship, all this has a beneficial effect on the economic growth of the national economy. But the effective development of the Arctic zone is possible only with comprehensive assistance from the state and the implementation of support programs.
Tools for Industrial Enterprises Management Based on the Principles of Lean Manufacturing and ESG
Authors: Sysoeva E. A. , Khoroshilova T. I. 
Published: May 2023

Relevance. To date, most industrial enterprises focus on "green" and environmental standards. Driven by stricter regulations, pressure from investors and changing customer preferences, companies are forced to use technologies that are either completely harmless or the least harmful in comparison with traditional production methods. Such actions involve modifications in many directions, including changes in supply chains, production processes and business models. Companies are also rethinking how their products are developed, designed and used, looking for ways to meet performance and quality requirements while using fewer resources throughout the life cycle of everything they produce.The purpose– the study of the management process of industrial enterprises based on the principles of lean manufacturing and ESG.Objectives: compare the similarities and differences between the principles of lean manufacturing and ESG; assess the current state of their implementation at industrial enterprises; as well as consider the criteria for assigning ratings.Methodology. In this research, theoretical (for example, analytical, descriptive, historical, etc.) and empirical (for example, comparative; forecasting and measurement) research methods are used.Results. The relevance of such industrial enterprise management tools, which are based on the principles of lean manufacturing and ESG, is revealed – today they are a priority for the economy. Conclusions. If an enterprise wants to be highly competitive, it should adhere to the continuous development and improvement of equipment that could reduce emissions into the environment. Such an indicator can be achieved with the introduction of lean manufacturing and ESG tools at the enterprise. Thus, it becomes clear that concern for the environment is closely linked to the success of firms.
Specifics of Development of Organic Agriculture in New Conditions
Authors: Dzhancharova G. K. , Adaev N. L. , Tserenov I. V. 
Published: May 2023

Relevance. Organic agriculture is a dynamically developing area of the global agro-industrial complex. The global problems of the climate plan and the depletion of natural resources throughout the planet dictate the need to revise the technologies used in food production. Excessive intensification of agricultural production due to mineralization and fertilization of soils, hormonal stimulation of the growth of animals and plants has led to a deterioration in the quality of water, soil, air and, in general, the health of the population. Therefore, the problem of reducing the anthropogenic impact on the environment is the main trend in the implementation of the principles of organic production.The purpose of this study is aimed at assessing the potential of organic agricultural production on the example of the leading countries and the problems associated with the development of this area in Russia.Objectives: to assess the volume of the world organic market and the dynamics of its development over 10 years; to consider the latest changes in the organization of Russian organic production after the entry into force of the N-208 Federal Law; to analyze the areas of organic agriculture by region and to identify countries leaders of organic production; refer to the experience of state support of the leading countries in organic production; assess the potential of Russian organic production; determine the future direction for the implementation of organic principles.Methodology. In the work, methods of scientific knowledge of a theoretical and methodological nature were used, graphs were used to illustrate the statistical data, and the method of generalization and synthesis was used to formulate conclusions.Results. Recommendations for the strategic development of the Russian market of organic production were developed within the framework of the current EAEU agreement.Conclusions. Conclusions are drawn about the expansion of state tools for stimulating the development of organic agricultural production in the context of changing world economic relations and integrations.
Reception of the Gastronomic Culture of Russia by Modern Restaurant Business in a Post-Coffee Situation
Authors: Volobuev V. V. , Tretyak A. S. , Saltinskii I. S. 
Published: May 2023

Relevance. The sphere of the restaurant industry considered in the article is in close contact with the economy of a particular region, as well as the economy of the country as a whole. The authors are convinced that the restaurant business, like many others, has suffered from the conditions of the coronavirus: a number of restrictive requirements were introduced in the service sector, enterprises were limited in the volume of services provided, in the ways of promoting services on the market. It is concluded that the given strategy of reforming the restaurant product in the economic reception of the gastronomic culture of Russia will give an incentive to the development of the domestic restaurant product.The purposeof the article is to provide an economic justification for the reception of the gastronomic culture of Russia by modern enterprises of the restaurant industry. Objectives: study of the theoretical foundations of the gastronomic brand; consideration of the historical aspect; formulation of a strategy for reforming the restaurant product in the economic reception of the gastronomic culture of RussiaMethodology. To analyze the works of domestic specialists who covered various aspects of restaurant services, state statistics and documentation, the authors relied on such methods as statistical and economic analysis, comparative assessment, causal analysis.Results. Based on the study of the theoretical foundations of the gastronomic brand as a phenomenon of economic theory and taking into account the historical aspect, recommendations were formed on reforming the domestic restaurant product at the reception of the gastronomic culture of Russia.Conclusions. The expert assessment of the economic efficiency of the gastronomic culture of Russia at the enterprises of the restaurant business reveals the problems of the domestic restaurant business. The presented reception routes are based on economic factors, the determining indicators of restaurant activity over the past 2 years are taken into account. According to the authors, the main factors of reforming the restaurant business in the post-crisis period are: the cultural and historical potential of the region, the conceptuality of institutions, target (consumer) audiences, the pricing policy of the enterprise, state support. The above justification will give an incentive to the development of the domestic restaurant product and will lead to an increase in the tourist attractiveness of the regions.
Innovations in the Field of Excursion Services in the Hotel Industry
Authors: Kopteva Z. Yu. , Fedorova A. R. 
Published: May 2023

Relevance. Sightseeing services are included in the list of additional hotel services and today are provided in almost all hotels, regardless of their category and reputation. Today, the Russian economy is under the influence of Western restrictive measures and cardinal changes that are taking place in international relations and world politics. In the context of the transformation of the Russian economy, the demand for domestic recreational and educational tourism is increasing, which is an impetus for the development and strengthening of domestic tourism. The article is devoted to the study of the application of modern technologies in the field of excursion service of hotels, using the example of virtual reality technologies.The purpose is to justify the introduction of modern technologies in the field of excursion services of the hotel industry. Objectives: to characterize the innovation, to determine the purpose of creating an innovation and its target audience, to consider the resources needed to create this innovation, and the expected result from it.Methodology. His research is organized on the search, scientific review and analysis of the material published in open sources (Internet resources) and printed scientific publications. The article also uses data from scientific publications published in printed sources. Based on the general logic of the article, the material was systematized and processed.Results. As a result, the rationale for the use of modern VR technologies in the field of excursion services of the hotel industry is given, the resources necessary for its creation are considered, the target audience and economic efficiency are determined. In addition, an important result is to increase the reputation of the hotel and its popularity in the market, which will lead to an increase in the flow of tourists and the profitability of the hotel enterprise.Conclusions. The proposed modern VR technologies are aimed at improving the field of excursion services of hotels, improving the quality of excursion services and meeting the cognitive needs of guests, increasing the volume of excursion services and the net profit of the hotel enterprise.
Characteristics of the Employment of the Population of Russia in the Informal Sector of the Economy
Authors: Merkulova E. Yu. , Fatkhutdinov A. A. 
Published: May 2023

Relevance. The shadow economy exists in all countries of the world, however, the scale of employment in it indicates the degree of development of state institutions. The presence of shadow relations in the economy leads to a decrease in the revenues of the budget system at different levels of government, so it is necessary to create legal and economic conditions to reduce the share of the informal sector of the economy. Unfavorable socio-economic conditions for development, as a rule, are associated with the departure of employment to the informal sector of the economy, so it is necessary to identify the portrait characteristics of the population employed in it.The purpose of this study is to develop tools to counter the employment of the population in the informal sector of the economy, based on an assessment of the level of employment by type of economic activity and portrait characteristics.Objectives: to study the dynamics and structure of employment in the informal sector of the economy; identify factors that affect the level of shadow employment; develop tools to counteract shadow relations and determine the conditions for reducing the level of the informal sector of the economy.Methodology. The methodological basis of the study is a comparative and correlation analysis, the study used methods for calculating absolute, relative indicators, graphical and tabular methods for displaying information. Results: an assessment of shadow relations in the economy was carried out; the dynamics of the level of employment in the informal sector of the economy is analyzed; the factors that have a significant impact on it are identified; approaches are proposed to reduce the threat of the growth of the scale of shadow relations.Conclusions. Many countries are actively working to identify the causes and conditions for the existence of shadow relations, including Russia is actively working in this direction. As a result of the analysis, we have proposed a toolkit for reducing the scale of employment in the informal sector of the economy.