bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney disease following COVID-19 vaccination: a single-center retrospective study
Authors: Chen Chien-Chou , Yang Sung-Sen , Hsu Yu-Juei , Sung Chih-Chien , Chu Pauling , Wu Chia-Chao , Hsu Shun-Neng , Wang Han-En , Lee Ding-Jie , Lin Shih-Hua 
Published: May 2023

BackgroundRare cases of de novo or relapsed kidney diseases associated with vaccination against coronavirus disease 2019 (COVID-19) have been increasingly reported. The aim of this study was to report the incidence, etiologies, and outcomes of acute kidney disease (AKD) following COVID-19 vaccination.MethodsThis retrospective study extracted cases from renal registry of a single medical center from 1 March 2021 to 30 April 2022, prior to the significant surge in cases of the Omicron variant of COVID-19 infection in Taiwan. Adult patients who developed AKD after COVID-19 vaccination were included. We utilized the Naranjo score as a causality assessment tool for adverse vaccination reactions and charts review by peer nephrologists to exclude other causes. The etiologies, characteristics, and outcomes of AKD were examined.ResultsTwenty-seven patients (aged 23 to 80 years) with AKD were identified from 1,897 vaccines (estimated rate of 13.6 per 1000 patient-years within the renal registry). A majority (77.8%) of vaccine received messenger RNA-based regimens. Their median (IQR) Naranjo score was 8 (6-9) points, while 14 of them (51.9%) had a definite probability (Naranjo score ≥ 9). The etiologies of AKD included glomerular disease (n = 16) consisting of seven IgA nephropathy, four anti-neutrophil cytoplasmic antibodies-associated glomerulonephritis (AAN), three membranous glomerulonephritis, two minimal change diseases, and chronic kidney disease (CKD) with acute deterioration (n = 11). Extra-renal manifestations were found in four patients. Over a median (IQR) follow-up period of 42 (36.5–49.5) weeks, six patients progressed to end-stage kidney disease (ESKD).ConclusionBesides glomerulonephritis (GN), the occurrence of AKD following COVID-19 vaccination may be more concerning in high-risk CKD patients receiving multiple doses. Patients with the development of de novo AAN, concurrent extra-renal manifestations, or pre-existing moderate to severe CKD may exhibit poorer kidney prognosis.
EGFR and ERBB2 exon 20 insertion/duplication in advanced non–small cell lung cancer: genomic profiling and clinicopathologic features
Authors: Sompallae Ramakrishna R. , Dundar Bilge , Guseva Natalya V. , Bossler Aaron D. , Ma Deqin 
Published: May 2023

BackgroundExon 20 (ex20) in-frame insertions or duplications (ins/dup) in epidermal growth factor receptor (EGFR) and its analog erb-b2 receptor tyrosine kinase 2 (ERBB2) are each detected in 1.5% of non–small cell lung cancer (NSCLC). Unlike EGFR p.L858R or ex19 deletions, ex20 ins/dup is associated with de novo resistance to classic EGFR inhibitors, lack of response to immune checkpoint inhibitors, and poor prognosis. US Food and Drug Administration has approved mobocertinib and amivantamab for targeting tumors with this aberration, but the number of comprehensive studies on ex20 ins/dup NSCLC is limited. We identified 18 cases of NSCLCs with EGFR/ERBB2 ex20 ins/dup and correlated the findings with clinical and morphologic information including programed death-ligand 1 (PD-L1) expression.MethodsA total of 536 NSCLC cases tested at our institution between 2014 and 2023 were reviewed. A custom-designed 214-gene next-generation sequencing panel was used for detecting DNA variants, and the FusionPlex CTL panel (ArcherDx) was used for the detection of fusion transcripts from formalin-fixed, paraffin-embedded tissue. Immunohistochemistry (IHC)for PD-L1 was performed using 22C3 or E1L3N clones.ResultsNine EGFR and nine ERBB2 ex20 ins/dup variants were identified from an equal number of men and women, 14 were non- or light smokers, and 15 had stage IV disease. All 18 cases were adenocarcinomas. Seven of the 11 cases with available primary tumors had acinar predominant pattern, two had lepidic predominant pattern, and the remainder had papillary (one case) and mucinous (one case) patterns. Ex20 ins/dup variants were heterogenous in-frame one to four amino acids spanning A767–V774 in EGFR and Y772–P780 in ERBB2 and were clustered in the loop following the C-helix and α C-helix. Twelve cases (67%) had co-existing TP53 variants. Copy number variation in CDK4 amplification was identified in one case. No fusion or microsatellite instability was identified in any case. PD-L1 was positive in two cases, low positive in four cases, and negative in 11 cases.ConclusionsNSCLCs harboring EGFR/ERBB2 ex20 ins/dup are rare and tend to be acinar predominant, negative for PD-L1, more frequent in non- or light smokers, and mutually exclusive with other driver mutations in NSCLC. The correlation of different EGFR/ERBB2 ex20 ins/dup variants and co-existing mutations with response to targeted therapy and the possibility of developing resistant mutations after mobocertinib treatment warrants further investigation.
The pharmacogenomic landscape of an Indigenous Australian population
Authors: Samarasinghe Sumudu Rangika , Hoy Wendy , Jadhao Sudhir , McMorran Brendan J. , Guchelaar Henk-Jan , Nagaraj Shivashankar H. 
Published: May 2023

Background: Population genomic studies of individuals of Indigenous ancestry have been extremely limited comprising &lt;0.5% of participants in international genetic databases and genome-wide association studies, contributing to a “genomic gap” that limits their access to personalised medicine. While Indigenous Australians face a high burden of chronic disease and associated medication exposure, corresponding genomic and drug safety datasets are sorely lacking.Methods: To address this, we conducted a pharmacogenomic study of almost 500 individuals from a founder Indigenous Tiwi population. Whole genome sequencing was performed using short-read Illumina Novaseq6000 technology. We characterised the pharmacogenomics (PGx) landscape of this population by analysing sequencing results and associated pharmacological treatment data.Results: We observed that every individual in the cohort carry at least one actionable genotype and 77% of them carry at least three clinically actionable genotypes across 19 pharmacogenes. Overall, 41% of the Tiwi cohort were predicted to exhibit impaired CYP2D6 metabolism, with this frequency being much higher than that for other global populations. Over half of the population predicted an impaired CYP2C9, CYP2C19, and CYP2B6 metabolism with implications for the processing of commonly used analgesics, statins, anticoagulants, antiretrovirals, antidepressants, and antipsychotics. Moreover, we identified 31 potentially actionable novel variants within Very Important Pharmacogenes (VIPs), five of which were common among the Tiwi. We further detected important clinical implications for the drugs involved with cancer pharmacogenomics such as thiopurines and tamoxifen, immunosuppressants like tacrolimus and certain antivirals used in the hepatitis C treatment due to potential differences in their metabolic processing.Conclusion: The pharmacogenomic profiles generated in our study demonstrate the utility of pre-emptive PGx testing and have the potential to help guide the development and application of precision therapeutic strategies tailored to Tiwi Indigenous patients. Our research provides valuable insights on pre-emptive PGx testing and the feasibility of its use in ancestrally diverse populations, emphasizing the need for increased diversity and inclusivity in PGx investigations.
Non-problem gamblers show the same cognitive distortions while playing slot machines as problem gamblers, with no loss of control and reduced reality control, though – An experimental study on gambling
Authors: Krébesz Róbert , Ötvös Dóra Kata , Fekete Zita 
Published: May 2023

BackgroundCognitive distortions can result in maladaptive interpretations of events and maladaptive behavior. In the case of gambling, such distortions can contribute to the maintenance of the disorder. Our current research aimed to conduct an experiment to possibly detect cognitive biases characteristic of persons with gambling addiction in a non-gambling sample of the general population, and to study the effect of “big win” on cognitive distortions.MethodsA specifically designed and preprogrammed slot machine simulation was carried out, with 90 rounds split into 3 sections. During the simulation every participant verbalized their thoughts and feelings; the verbalizations were recorded. Then a content analysis was conducted to search for indications of cognitive distortions. The sample was separated into two experimental groups: one of the groups experienced the “big wins” in the first section, while the other group had them in the second section of the experiment.ResultsContent analysis revealed numerous cognitive biases. Cognitive distortions usually present in problem gambling were detected in our sample from the general population as well. However, we could not distinguish cognitive biases indicating serious loss of control, or distortion of reality control. A further finding is that early losses provoke the emergence of more cognitive distortions, while early big win leads to more intense loss-chasing in the later stages of gambling.ConclusionThe appearance of reality-checking uncertainty or loss of control can be alarming for the development of gambling. Losses and big wins can provoke different cognitive distortions, encouraging the person into further gambling behavior.
A modified two-dimensional sensory organization test that assesses both anteroposterior and mediolateral postural control
Authors: Wagner Andrew R. , Merfeld Daniel M. 
Published: May 2023

BackgroundThe Sensory Organization Test (SOT) was designed to measure changes in postural control in response to unreliable visual and/or proprioceptive feedback. However, secondary to the manipulation of sensory cues in only the sagittal plane, the SOT is capable of only describing postural control in a single direction. The present study aimed to characterize postural responses to a modified SOT designed to concurrently challenge both anteroposterior and mediolateral postural control.MethodsTwenty-one healthy adult volunteers (30.6 ± 10.2 years) completed the standard anteroposterior one-dimensional (1D) SOT, in addition to a modified SOT with the support surface sway-referenced to both anteroposterior and mediolateral postural sway (two-dimensional, 2D). Our primary analysis concerned a comparison of mediolateral, as well as anteroposterior postural sway measured during the standard one-dimensional (i.e., pitch tilt) and the novel two-dimensional (i.e., roll and pitch tilt) sway-referenced paradigms. Here, postural sway was quantified by calculating the root mean square distance (RMSD) of the center of pressure (CoP) during each trial.ResultsOur data showed that the 2D sway-referenced conditions yielded a selective increase in mediolateral postural sway relative to the standard 1D conditions for both wide (η2 = 0.66) and narrow (η2 = 0.78) stance conditions, with anteroposterior postural sway being largely unaffected (η2 = 0.001 to 0.103, respectively). The ratio between mediolateral postural sway in the sway-referenced conditions and postural sway in the corresponding stable support surface conditions was greater for the 2D (2.99 to 6.26 times greater) compared to 1D paradigms (1.25 to 1.84 times greater), consistent with a superior degradation of viable proprioceptive feedback in the 2D paradigm.ConclusionA modified 2D version of the SOT was shown to provide a greater challenge to mediolateral postural control relative to the standard 1D SOT protocol, putatively as a result of a superior capacity to degrade proprioceptive feedback in the mediolateral direction. Given these positive findings, future studies should investigate the clinical utility of this modified SOT as a means by which to better characterize sensory contributions to postural control in the presence of various sensorimotor pathologies, including vestibular hypofunction.
Comparison of non-invasive ventilation use and outcomes in children with Down syndrome and other children using this technology
Authors: Valji Rafiaa , Castro-Codesal Maria L. , Lewis Melanie , MacLean Joanna E. 
Published: May 2023

RationaleChildren with Down syndrome (DS) make up a substantial portion of long-term non-invasive ventilation (LT-NIV) users though it is unclear if their unique features alter LT-NIV efficacy or use. The aim of this study is to compare the use and outcomes of LT-NIV for children with DS and a matched comparison (MCG).MethodsThis is a sub-study of a 10-year retrospective review of children initiated on LT-NIV in Alberta, Canada (N = 622). Children with DS (n = 106) were matched in a 1:2 ratio with other children using LT-NIV based on age and therapy start date. Data was collected from medical and sleep laboratory records.ResultsUpper airway disease was the most common indication for LT-NIV in both groups, though was higher in children with DS (DS: 90% vs. MCG: 50%, OR 8.64 [95% CI 4.38–17.04]). Sleep and respiratory parameters, at the baseline diagnostic sleep study and the change from baseline to treatment study, did not differ between groups. Nasal masks were the predominant mask type in both children with DS (55%) and the MCG (66%) with more children with DS, compared to the MCG, using full face masks (DS: 45 vs. MCG: 33%, p &lt; 0.05). Continuous positive airway pressure was used more often in children with DS (93.3% vs. 69.2%, p &lt; 0.001) while bilevel-positive airway pressure was more common in the MCG (DS: 6.7% vs. MCG 30.8%, p &lt; 0.001). Children with DS were followed longer than children in the MCG (DS: 2.4 [IQR 2.8] vs. MCG: 1.8 [IQR 2.7] years, p &lt; 0.05). Adherence was lower in children with DS at both 6–12 month follow-up and most recent visit with a similar decrease in adherence in both groups over the follow-up period (0.0 [IQR 1.4] vs. −0.3 [IQR 2.0]. Despite this, 66% and 49% of children with DS used LT-NIV for more than 4 h/night at the 6–12 month and most current visit, respectively. Discontinuation of LT-NIV and mortality did not differ between groups.ConclusionLT-NIV is a common and efficacious treatment in children with DS used predominantly for upper airway obstruction. While adherence is lower, the majority of children with DS are successful at using LT-NIV.
Application of infraorbital rim augmentation with pocket fat filling to correct tear trough deformity
Authors: Liu Yukun , Wang Yi , Cai Changqi , Wu Xiuying , Wang Haiping 
Published: May 2023

BackgroundTear trough deformity is one of the most common complaints in clinical settings. The correction of this groove is challenging in facial rejuvenation. The lower eyelid blepharoplasty varies with different conditions. A novel approach of using orbital fat in the lower eyelid to increase the volume of the infraorbital rim with granule fat injection has been applied in our institution for more than 5 years.ObjectivesThis article aims to describe the detailed steps of our technique and verify its effectiveness by a cadaveric head dissection after surgical simulation.MethodsIn this study, a total of 172 patients with tear trough deformity underwent lower eyelid orbital rim augmentation with fat filling in the sub-periosteum pocket. According to Barton's grades, 152 patients underwent lower eyelid orbital rim augmentation with orbital fat filling, 12 patients had it combined with autologous granule fat from other body parts, and 8 patients received only transconjunctival fat removal to correct tear trough.ResultsThe modified Goldberg score system was used to compare preoperative and postoperative photographs. Patients were satisfied with the cosmetic results. Excessive protruding fat was released, and the tear trough groove was flattened by using autologous orbital fat transplantation. The lower eyelid sulcus deformities were well-corrected. To further illustrate the anatomical structure of the lower eyelid area and injection layers, six cadaveric heads were used for surgical simulation and demonstrated the effectiveness of our technique.ConclusionsThis study indicated that the infraorbital rim could be increased by transplanting orbital fat to the pocket, which was dissected under the periosteum, and the procedure has been verified as reliable and effective.Evidence-based medicine (EBM) levelLevel II.
Analisa Dan Evaluasi Sistem Transportasi Publik Bus Rapid Transit (Brt) Trans Semarang Koridor Iv Kota Semarang
Authors: Widodo Agus , Yudho Putranto Ardi , Handajani Mudjiastuti , Muldiyanto Agus 
Published: May 2023

Pertumbuhan penduduk membuat transportasi di Indonesia khususnya di Kota Semarang juga semakin berkembang, salah satu transportasi umum yang sedang dikembangkan di Kota Semarang saat ini adalah BRT. Dari 7 koridor yang beroperasi, BRT koridor IV (empat) banyak ditemui kendala dan permasalahan diantaranya adalah sedikitnya jumlah penumpang bus sehingga pendapatan dari tarif yang didapat belum menutupi biaya operasional. Penelitian ini bertujuan mengetahui tentang standar pelayanan yang ada pada BRT di Koridor IV Semarang; Menganalisa kinerja dan pelayanan bus BRT di Koridor IV Semarang berdasarkan jumlah penumpang, kecepatan perjalanan, load factor, headway, dan jumlah armada; dan Mengetahui hal-hal yang perlu diperbaiki pada transportasi ini. Metode yang di pakai adalah observasi lapangan dan analisa data sekunder. Hasil penelitian menunjukan bahwa BRT Trans Semarang Koridor IV memiliki 20 armada dengan rincian 18 armada beroperasi dan 2 armada untuk cadangan. Nilai load factor sebesar 53% dimana memenuhi standar yang ada, nilai headway sebesar 13,51 menit dimana belum sesuai dengan syarat yang ada. Kecepatan rata-rata 14,68 km/jam dimana dibawah batas aturan dan jarak tempuh 237,04 km dimana tidak sesuai dengan standar jarak perjalanan.
Analisis Perbandingan Biaya Dan Waktu Penggunaan Metode Risba Dan Metode Konvensional Pada Struktur Bangunan Rumah Tinggal
Authors: Crista Ngudi 
Published: May 2023

Abstrak
Rumah tinggal pada umumnya dibangun menggunakan metode pengerjaan konvensional dengan bahan dasar struktur menggunakan beton, besi tulangan dan bekisting. Struktur bangunan pada rumah tinggal merupakan komponen utama yang menjadi kerangka terbentuknya sebuah bangunan, kokoh atau rapuhnya sebuah bangunan terlihat dari metode dan material yang digunakan untuk menyusun struktur bangunannya. Risba merupakan kepanjangan dari Rumah Instan Baja yang menjadi salah satu rumah tahan gempa yang dikenalkan oleh dosen UGM, Metode Risba telah diteliti mengenai material baja yang digunakan dengan melakukan pengujian balok, sloof dan kolom menggunakan CNP dobel dengan metode pembebanan monotonic. Perkiraan biaya dan waktu yang dibutuhkan dalam setiap pekerjaan konstruksi dengan komponen perencanaan biaya dan waktu terdiri dari tenaga kerja dan peralatan serta material yang digunakan. Pembangunan rumah tinggal 2 lantai tipe 72 dengan menggunakan metode konvensional dan metode risba didapatkan selisih biaya sebesar Rp 13.059.024,00 dengan kata lain bahwa struktur bangunan dengan metode risba lebih murah 17 %.
Penerapan Value Engineering Untuk Meminimalisir Faktor Penyebab Adanya Sisa Material Konstruksi
Authors: Haryanto  
Published: May 2023

Pada pelaksanaan suatu proyek terdapat permasalahan yang masih terbilang perlu diteliti lagi pada dunia konstruksi yang berkaitan dengan keefektifan, efisiensi dan ekonomis. Salah satu cara yang terdekat adalah penerapan value engineering pada proyek konstruksi. Metode Analisa Value Engineering memiliki kelebihan, yaitu adanya upaya pendekatan yang sistematis, rapi, dan terorganisir dalam menganalisa nilai (value) dari pokok permasalahan terhadap fungsi tetapi tetap konsisten terhadap kebutuhan akan penampilan, kualitas, dan pemeliharaan dari proyek. Tahapan Value Engineering yaitu: tahap informasi dari proses Value Engineering meliputi merumuskan masalah, mengumpulkan data, mengenal objek (produk) dengan mengkaji fungsi dan mencatat biaya. Berdasarkan hasil analisa dan evaluasi yang telah dilakukan untuk perhitungan sisa material (waste) pada Proyek Pembangunan Gedung Madrasah Tsanawiyah Negeri 2 (Gedung A) yang menjadi penyebab terjadinya sisa material diantaranya: (a) indikator faktor manusia memiliki nilai mean 2.98 dan ranking 1; (b) indikator faktor lapangan memiliki nilai mean 3.06 dan ranking 1; (c) indikator pengadaan material memiliki nilai mean 2.90 dan ranking 1; (d) indikator metode kerja memiliki nilai mean 3.08 dan ranking 1; dan (e) indikator Alat/Mesin memiliki nilai mean 2.98 dan ranking 1. Dari hasil perhitungan value engineering dapat dihemat biaya pembangunan Proyek Pembangunan Gedung Madrasah Tsanawiyah Negeri 2 (Gedung A) sebesar Rp. 70.788.369,43.
Hommes et dieux dans l’Énéide. À la mémoire de Jacqueline Dangel
Authors: Loupiac Annie 
Published: May 2023

As emphasized in the proemium, the relationships between men and god are essential in the Aeneid. As an epic poet, Virgil draws from the great mythological scenes he finds in Homer and adapts them to hisRoman audience. As a philosopher, hewants, through the myth of Aeneas, to convince of the action of Providence made tangible in the many prophecies and of the necessity of virtue to ensure the immortality of heroes and cities. As a Roman citizen, he offers his city a new kind of religious approach by separating the political and religious powers, by defining a new form of worship and giving Apollo the status of main god. The Aeneid can therefore appear as an example of the Varronian
three theologies.
L’In Alethium de Claudien : de l’épigramme à l’invective, propositions pour une lecture
Authors: Garambois-Vasquez Florence 
Published: May 2023

This article suggests an interpretation of an epigram of the Claudianean corpus of
Carmina Minora focusing on the high strained rhetorical structure. The metatextual
dimension of the poem strengthens its ironical scope. More than a satiric epigram, the In Alethium appears as a miniature invective.
Quelques considérations sur les sept rois de Rome (I)
Authors: Cairo Giambattista 
Published: May 2023

The author takes again into consideration the question about the royal period of Rome.
He reverses the usual interpretation according to which it is the traditional list of seven kings of Rome that has permitted to establish the date of Rome’s foundation by a retrospective calculation : in the author’s opinion the foundation’s date is pre-existent in the annalistic tradition and it is from this date that the kings’ list, based on the «empirical principle of generations » , was formed. The author reaches two conclusions : 1. the succession to the throne of Rome happened from grandfather to grandson ¢ 2. the women had an essential part in this process. This scheme works only if the first chief of Roman community is identified as Hostilius (the Romulus’ fellow-soldier) and this Hostilius as the grandfather of Tullus Hostilius, the first king of Rome.
Le spectacle de l’intime. Espace et circulation de la parole dans l’Oedipe de Sénèque
Authors: Garelli-François Marie-Hélène 
Published: May 2023

The sight of intimacy. Space and motion of speech in Seneca’s Oedipus
A study concerning the use of the spatial agreements as well as the internal stage directions in Oedipus shows that Seneca knows and respects the dramatical antique conventions (the ones of his model as well as those of the roman theatre). The comparison of the number, the place and the function of the stage directions in Sophocles’Oedipus tyrannus and Seneca’s Oedipus shows that Seneca makes the choice of stage directions with an emotional value that points out, like «indications » , the scenes of exteriorization of Oedipus’s inside monsters, when the stage directions which structured the scenes of questioning and of the progressive discovery of his culpability by the hero are neglected. Moreover Seneca stylizes the ritual exchanges prior to the dialogues, cancelling the connections of speech in the beginning of the scene : a stage direction at the end of the chorus transmits the speech to the hero and allows him to exteriorize his culpability, theatricalizing it.