bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lachman Test on ACLR With Internal Bracing at Hasan Sadikin General Hospital Bandung
Authors: Nugraha Yudi Purnama , Utoyo Ghuna Arioharjo 
Published: February 2023

Introduction: The growing popularity of recreational and competitive sport activities has contributed to an increased number of anterior cruciate ligament (ACL) injuries in the past three decades. Because of its varying success rates, anterior cruciate ligament reconstruction (ACLR) is considered the gold standard surgical treatment for ACL rupture. ACLR in hyperlaxity patients has unpredictable outcomes because of its flexibility, therefore utilizing an internal brace aims to obtain a rigid fixation such as the enthesis structure. Methods: This prospective case series study was done from August 2021 to March 2022. Laxity was assessed using Beighton score, and patients were divided into three groups based on clinical laxity and surgical management that performed. Group 1 was no laxity patients performed ACLR without internal bracing, group 2 was laxity patients performed ACLR without internal bracing and group 3 was laxity patients performed ACLR with internal bracing. We conducted ACLR on 34 patients with a mean age of 35±6.71 years old. Twenty four patients had laxity with Beighton score 4–9. Ten patients had no laxity with Beighton score 0-3. ACLR were done with internal bracing augmentation for 15 patients with laxity. ACLR without internal bracing were done for 19 patients. Post-surgery follow up were scheduled at 1 and 3 months using Lachman test. Patients with no anterior displacement is considered as negative Lachman test , while patients with 0-5 mm, 5-10 mm, and >10 mm of anterior displacement were considered as Lachman test grade 1, grade 2, and grade 3 respectively. Results: All patients completed 1 and 3 months post-operation follow-up using Lachman test. After 3 months follow-up, in group of patients with no laxity performed ACLR, negative Lachman test was found in 7 participants (70 %), and grade 1 was found in 3 participants (30 %). %) In group of laxity patients performed ACLR without internal bracing, negative Lachman test was found in 4 participants (44.4%), grade 1 in 2 participants (22.2%) and grade 2 in 3 participants (33.3%). Meanwhile in group of laxity patients performed ACLR with internal bracing, negative Lachman test was found in 12 participants (80%), grade 1 in 2 participants (13.3%) and grade 2 in 1 participant (6.7%). Negative Lachman test after 3 months follow up was found higher in patients performed ACLR with internal bracing. Discussion: Our results showed that patients who received ACLR with internal bracing recovered 80% of the time by the Lachman test after 3 months. Internal brace reduce graft failure and improve rehabilitation in ACLR. The limitation of this study was a subjective result performing Lachman test examination. A junior resident, senior resident and sport injury consultant may had different Lachman test valuation. Conclusion: The difference between preoperative and postoperative Lachman test results were statistically significant on laxity patients underwent anterior cruciate ligament reconstruction with internal bracing.
A Case Series of Successful Lateral Extra-articular Tenodesis (LET) in ACL Reconstruction
Authors: Ramadhani Rahadiansyah , Lubis Andri MT 
Published: February 2023

Introduction: In the United States, 80.000-100.000 Anterior Cruciate Ligament (ACL) injury repairs are performed annually. Recent development added lateral extra-articular tenodesis (LET) to improve the outcome of ACL reconstruction. This research evaluates the outcome of LET in ACL injury based on our experiences evaluated in effectiveness and complication. Methods: This case series included three patients diagnosed with ACL rupture in Cipto Mangunkusumo General Hospital from January to February 2022. All patients underwent ACL reconstruction followed by LET. Results: In our studies, all of our cases underwent surgery with successful clinical outcomes. In addition, all patients in our studies also reported no complications postoperatively. Conclusion: The addition of LET in ACL reconstruction was found to be successful with no complications. Further application of the method is endorsed to bring more benefits with less risk of side effects or failure. Follow-up should be done to observe the long-term effects of the method.
Return to Sport After Arthroscopic Capsular Repair in Elite Baseball Players
Authors: Uffmann William J. , ElAttrache Neal S. , Youssefzadeh Keon , Carbone Andrew , Limpisvasti Orr 
Published: February 2023

Background: Chronic attritional midsubstance capsular tears arising from repetitive throwing stress are a rare but important source of pain and dysfunction in elite baseball players; however, little is known regarding outcomes after arthroscopic capsular repair. Purpose: To evaluate the patient-reported outcomes and return-to-sport (RTS) rates after arthroscopic capsular repair in elite baseball players. Study Design: Case series; Level of evidence, 4. Methods: We identified 11 elite-level baseball players who were treated with arthroscopic repair for a midsubstance glenohumeral capsular tear by a single surgeon with a uniform approach and a standardized postoperative protocol between 2012 and 2019. All players had at least 2 years of follow-up data. Demographic data and concomitant surgical procedures were recorded. Preoperative and postoperative Kerlan-Jobe Orthopaedic Clinic (KJOC) scores and Single Assessment Numeric Evaluation (SANE) scores were collected in a subset of the cohort, and statistical comparisons were made. A telephone survey was conducted to determine the patients’ RTS level and outcome scores. Statistical comparisons between preoperative and postoperative outcomes scores were made using t tests. Results: Eight major league players, 1 minor league player, and 2 collegiate players were included. There were 9 pitchers, 1 catcher, and 1 outfielder. All patients had debridement of the posterosuperior labrum and rotator cuff. Two pitchers underwent a rotator cuff repair, and 1 outfielder underwent a posterior labral repair. The mean age at the time of surgery was 26.9 years (range, 20-34 years), with a mean follow-up of 3.5 years (range, 2.6-5.9 years). There were significant preoperative versus postoperative improvements in the mean KJOC (20.6 vs 89.8; P = .0002) and SANE (28.3 vs 86.7; P = .001) scores. All patients reported a high degree of satisfaction. At a mean of 16.3 months (range, 6.5-25.4 months), 10 of 11 (90.1%) players met the Conway-Jobe good or excellent criteria for RTS. Conclusion: Arthroscopic capsular repair provided significant improvements in functional outcomes in elite baseball players, high levels of patient satisfaction, and high levels of RTS.
Modulation of defense genes and phenolic compounds in wild blueberry in response to Botrytis cinerea under field conditions
Authors: Abbey Joel , Jose Sherin , Percival David , Jaakola Laura , Asiedu Samuel K. 
Published: February 2023

AbstractBotrytis blight is an important disease of wild blueberry [(Vaccinium angustifolium (Va) and V. myrtilloides (Vm))] with variable symptoms in the field due to differences in susceptibility among blueberry phenotypes. Representative blueberry plants of varying phenotypes were inoculated with spores of B. cinerea. The relative expression of pathogenesis-related genes (PR3, PR4), flavonoid biosynthesis genes, and estimation of the concentration of ten phenolic compounds between uninoculated and inoculated samples at different time points were analyzed. Representative plants of six phenotypes (brown stem Va, green stem Va, Va f. nigrum, tall, medium, and short stems of Vm) were collected and studied using qRT-PCR. The expression of targeted genes indicated a response of inoculated plants to B. cinerea at either 12, 24, 48 or 96 h post inoculation (hpi). The maximum expression of PR3 occurred at 24 hpi in all the phenotypes except Va f. nigrum and tall stem Vm. Maximum expression of both PR genes occurred at 12 hpi in Va f. nigrum. Chalcone synthase, flavonol synthase and anthocyanin synthase were suppressed at 12 hpi followed by an upregulation at 24 hpi. The expression of flavonoid pathway genes was phenotype-specific with their regulation patterns showing temporal differences among the phenotypes. Phenolic compound accumulation was temporally regulated at different post-inoculation time points. M-coumaric acid and kaempferol-3-glucoside are the compounds that were increased with B. cinerea inoculation. Results from this study suggest that the expression of PR and flavonoid genes, and the accumulation of phenolic compounds associated with B. cinerea infection could be phenotype specific. This study may provide a starting point for understanding and determining the mechanisms governing the wild blueberry-B. cinerea pathosystem.
Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research
Authors: Rabin Borsika A. , Cain Kelli L. , Salgin Linda , Watson Paul L. , Oswald William , Kaiser Bonnie N. , Ayers Lawrence , Yi Crystal , Alegre Alexander , Ni Jessica , Reyes Allyn , Yu Kasey E. , Broyles Shelia L. , Tukey Robert , Laurent Louise C. , Stadnick Nicole A. 
Published: February 2023

Abstract
Background
Community Advisory Boards (CABs) have been frequently used to engage diverse partners to inform research projects. Yet, evaluating the quality of engagement has not been routine. We describe a multi-method ethnographic approach documenting and assessing partner engagement in two “virtual” CABs, for which we conducted all meetings remotely.

Methods
Two research projects for increasing equitable COVID-19 testing, vaccination, and clinical trial participation for underserved communities involved remote CAB meetings. Thirty-three partners representing 17 community groups participated in 15 sessions across the two CABs facilitated by a social change organization. We developed ethnographic documentation forms to assess multiple aspects of CAB member engagement (e.g., time spent speaking, modality used, types of interactions). Documenters were trained to observe CAB sub-groups via virtual sessions. Debriefing with the documentation team after CAB meetings supported quality assurance and process refinement. CAB members completed a brief validated survey after each meeting to assess the quality and frequency of engagement. Content and rapid thematic analysis were used to analyze documentation data. Quantitative data were summarized as frequencies and means. Qualitative and quantitative findings were triangulated.

Results
A total of 4,540 interactions were identified across 15 meetings. The most frequent interaction was providing information (44%), followed by responding (37–38%). The quality and frequency of stakeholder engagement were rated favorably (average 4.7 of 5). Most CAB members (96%) reported good/excellent engagement. Specific comments included appreciation for the diversity of perspectives represented by the CAB members and suggestions for improved live interpretation. Debriefing sessions led to several methodological refinements for the documentation process and forms.

Conclusion
We highlight key strategies for documenting and assessing community engagement. Our methods allowed for rich ethnographic data collection that refined our work with community partners. We recommend ongoing trainings, including debriefing sessions and routinely reviewed assessment of data to strengthen meaningful community engagement.
Improving adolescent health literacy through school-based health literacy intervention: a mixed-method study protocol
Authors: Khanal Shanti Prasad , Budhathoki Chitra Bahadur , Okan Orkan 
Published: February 2023

AbstractBackgroundHealth-promoting actions might benefit from adolescent health literacy (AHL), however, there is scant research on it in Nepal. This study identifies adolescent students’ health literacy (HL) needs and trials an intervention to improve their HL and intention to take health-promoting actions.MethodsThis study employs a pre-and post-test mixed-method intervention involving three phases. First, we will conduct a formative and summative evaluation to identify participants’ HL needs and design an intervention using quantitative and qualitative methods. Second, the intervention will be administered to the intervention group. Finally, formative and summative post-tests will be conducted to assess the effectiveness of the intervention. We will select four community schools from Birendranagar municipality based on random sampling. In quantitative research, data will be collected from adolescents selected through a census with standardized scales such as the HLS-Child-Q15, self-efficacy, social support, and health-promoting actions. A framework analysis was conducted to analyze qualitative data collected from focus group discussions with purposively chosen adolescents and key informant interviews with Health and Physical Education teachers and school nurses. Thedifference in differenceapproach will be used to analyze the intervention’s outcome, i.e., the participants’ improved HL, and health-promoting actions.DiscussionThis is one of the first studies to explore HL in this group in Nepal. This study will provide the first insights into the overall level of AHL, potential AHL determinants, and the relationship between AHL and the intention to participate in health-promoting activities. The data can then be used to inform health promotion and health literacy initiatives.
Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial (CREDIT-2)
Authors: Chai Meng , He Yongming , Zhao Wang , Han Xuebin , Zhao Guoyan , Ma Xueping , Qiao Ping , Shi Dongmei , Liu Yuyang , Han Wei , An Pei , Li Haoyu , Yan Shuling , Ma Qingyang , Deng Huan , Qian Lei , Zhou Yujie ,   on behalf of CREDIT-2 investigators
Published: February 2023

Abstract
Background
Heterozygous familial hypercholesterolemia (HeFH) is largely underdiagnosed and undertreated in China where few patients achieved recommended target levels of low density lipoprotein cholesterol (LDL-C). We conducted the first randomized, placebo-controlled clinical trial in Chinese patients with HeFH to assess the efficacy and safety of tafolecimab, a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody.

Methods
Patients diagnosed with HeFH by Simon Broome criteria and on a stable lipid-lowering therapy for at least 4 weeks were randomized 2:2:1:1 to receive subcutaneous tafolecimab 150 mg every 2 weeks (Q2W), tafolecimab 450 mg every 4 weeks (Q4W), placebo Q2W or placebo Q4W in the 12-week double-blind treatment period. After that, participants received open-label tafolecimab 150 mg Q2W or 450 mg Q4W for 12 weeks. The primary endpoint was the percent change from baseline to week 12 in LDL-C levels. Secondary endpoints included proportion of participants achieving ≥50% LDL-C reductions and proportion of participants with LDL-C <1.8 mmol/L at week 12 and 24, the change from baseline to week 12 in non-high density lipoprotein cholesterol (non-HDL-C), apolipoprotein B and lipoprotein(a) levels, as well as the change from baseline to week 24 in lipid levels.

Results
In total, 149 participants were randomized and 148 received at least one dose of the study treatment. At week 12, tafolecimab treatment induced significant reductions in LDL-C levels (treatment difference versus placebo [on-treatment estimand]: −57.4% [97.5% CI, −69.2 to −45.5] for 150 mg Q2W; −61.9% [−73.4 to −50.4] for 450 mg Q4W; both P <0.0001). At both dose regimens, significantly more participants treated with tafolecimab achieved ≥50% LDL-C reductions or LDL-C <1.8 mmol/L at week 12 as compared with corresponding placebo groups (all P <0.0001). Meanwhile, non-HDL-C, apolipoprotein B and lipoprotein(a) levels were significantly reduced in the tafolecimab groups at week 12. The lipid-lowering effects of tafolecimab were maintained till week 24. During the double-blind treatment period, the most commonly-reported adverse events in the tafolecimab groups included upper respiratory tract infection, increased blood creatine phosphokinase, increased alanine aminotransferase, increased aspartate aminotransferase and hypertension.

Conclusions
Tafolecimab administered either 150 mg Q2W or 450 mg Q4W yielded significant and persistent reductions in LDL-C levels and showed a favorable safety profile in Chinese patients with HeFH.

Trial registration
ClinicalTrials.gov, NCT04179669.
A novel videoscope and tool kit for percutaneous pericardial access under direct visualization
Authors: Opfermann Justin D. , Contento Jacqueline M. , Mass Paige N. , Krieger Axel , Berul Charles I. , Kumthekar Rohan N. 
Published: February 2023

Abstract
Background
Pericardial access is necessary for the application of epicardial cardiac therapies including ablation catheters, pacing and defibrillation leads, and left atrial appendage closure systems. Pericardial access under fluoroscopic guidance is difficult in patients without pericardial effusions and may result in coronary artery damage, ventricular injury, or perforation with potentially life-threatening pericardial bleeding in up to 10% of cases. There is a clinical need for a pericardial access technique to safely deliver epicardial cardiac therapies.

Methods
In this paper, we describe the design and evaluation of a novel videoscope and tool kit to percutaneously access the pericardial space under direct visualization. Imaging is performed by a micro-CMOS camera with an automatic gain adjustment software to prevent image saturation. Imaging quality is quantified using known optical targets, while tool performance is evaluated in pediatric insufflation and pericardial access simulators. Device safety and efficacy is demonstrated by infant porcine preclinical studies (N = 6).

Results
The videoscope has a resolution of 400 × 400 pixels, imaging rate of 30 frames per second, and fits within the lumen of a 14G needle. The tool can resolve features smaller than 39.4 µm, achieves a magnification of 24x, and has a maximum of 3.5% distortion within the field of view. Successful pericardial access was achieved in pediatric simulators and acute in vivo animal studies. During in vivo testing, it took the electrophysiologist an average of 66.83 ± 32.86 s to insert the pericardial access tool into the thoracic space and visualize the heart. After visualizing the heart, it took an average of 136.67 ± 80.63 s to access the pericardial space under direct visualization. The total time to pericardial access measured from needle insertion was 6.7 × quicker than pericardial access using alternative direct visualization techniques. There was no incidence of ventricular perforation.

Conclusions
Percutaneous pericardial access under direct visualization is a promising technique to access the pericardial space without complications in simulated and in vivo animal models.
Reducing inequities in maternal and child health in rural Guatemala through the CBIO+ approach of Curamericas: 2. Study site, design, and methods
Authors: Perry Henry B. , Valdez Mario , Blanco Stanley , Llanque Ramiro , Martin Shayanne , Lambden Jason , Gregg Corey , Leach Kaitlin , Olivas Elijah , Muffoletto Barbara , Wallace Jacqueline , Modanlo Nina , Pfeiffer Erin , Westgate Carey C. , Lesnar Breanne , Stollak Ira 
Published: February 2023

Abstract
Background
The Curamericas/Guatemala Maternal and Child Health Project, 2011–2015, included implementation research designed to assess the effectiveness of an approach referred to as CBIO+﻿ , composed of: (1) the Census-Based, Impact-Oriented (CBIO) Approach, (2) the Care Group Approach, and (3) the Community Birthing Center Approach. This is the second paper in a supplement of 10 articles describing the implementation research and its findings. Paper 1 describes CBIO+ , the Project Area, and how the Project was implemented.

Objective
This paper describes the implementation research design and details of how it was carried out.

Methods
We reviewed the original implementation research protocol and the methods used for all data collection related to this Project. The protocol and methods used for the implementation research related to this Project were all standard approaches to the monitoring and evaluation of child survival projects as developed by the United States Agency for International Development Child Survival and Health Grants Program (CSHGP) and the CORE Group. They underwent independent peer review supervised by the CSHGP before the implementation research began.

Results
The study area was divided into two sets of communities with a total population of 98,000 people. Project interventions were implemented in Area A from 2011 until the end of the project in 2015 (44 months) and in Area B from late 2013 until 2015 (20 months). Thus, Area B served as a quasi-comparison area during the first two years of Project implementation. The overarching study question was whether the CBIO+ Approach improved the health and well-being of children and mothers. The outcome indicators included (1) changes in population coverage of evidence-based interventions, (2) changes in childhood nutritional status, (3) changes in the mortality of children and mothers, (4) quality of care provided at Community Birthing Centers, (5) the impact of the Project on women’s empowerment and social capital, (6) stakeholder assessment of the effectiveness of the CBIO+ Approach, and (7) the potential of wider adoption of the CBIO+ Approach.

Conclusion
The implementation research protocol guided the assessment of the effectiveness of the CBIO+ Approach in improving the health and well-being of children, mothers, and their communities.