bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luminescent Organosilane and Organogermane MR‐TADF Emitters for Operationally Stable Blue Organic Light‐Emitting Diodes
Authors: Li Si‐Jie , Tang Xiongkai , Ng Chiu Hwi , Lim Jia Yang , Tang Wai Kit , Chen Wen‐Cheng , Huo Yanping , Ng Maggie , Chen Season Si , Zhang Dongdong , Duan Lian , Tang Man‐Chung 
Published: January 2025

AbstractImproving operational stability for organic light‐emitting diode (OLED) is a hotspot in scientific research. It is proposed that silicon (Si) and germanium (Ge) can exhibit hyperconjugation effects and participate in conjugated systems, thereby stabilizing molecules’ excited and polarized states. Herein, the importance of incorporating Si and Ge in multi‐resonance thermally activated delayed fluorescence emitters is revealed to improve their luminescence efficiency and intrinsic stability. Computational studies show that introducing Si and Ge atoms can strengthen the C−Si and C−Ge bonds due to the hyperconjugation effect, resulting in higher bond dissociation energies and molecular photostability. With the efficient spin‐vibronic coupling and spin‐orbital coupling, the flexible conformations of the emitters facilitate the spin‐flip processes by enriching the characters and density of their excited states. A maximum external quantum efficiency of 30.0% for BN‐Ge‐based blue‐emitting OLEDs, with (Commission Internationale de l'Eclairage) CIEy ≤ 0.18 is realized. In particular, the LT90 at 1000 cd m−2 of 48.3 and 7.1 h is achieved for BN‐Si‐based and BN‐Ge‐based OLEDs, respectively, using the developed deuterated SiCzCz‐d15 and SiTriCz2‐d16 as the hole‐transporting and host materials. It is anticipated that the study will provide insights into the design of group IV element‐containing multiple‐resonance thermally activated delayed fluorescent emitters for optoelectronics applications.
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents
Authors: Fang Laiping , Chen Zengzhen , Dai Jianan , Pan Yujin , Tu Yike , Meng Qi , Diao Yanzhao , Yang Shuaibo , Guo Wei , Li Liming , Liu Jinwu , Wen Hua , Hua Kelei , Hang Lifeng , Fang Jin , Meng Xianwei , Ma Ping'an , Jiang Guihua 
Published: January 2025

AbstractPhotodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies to improve the performance of PDT or PTT by optimizing the structural design of SCOPAs. These strategies encompass augmenting reactive oxygen species (ROS) generation, mitigating oxygen dependence, elevating light absorption capacity, broadening the absorption region, and enhancing the photothermal conversion efficiency (PCE). Additionally, this review also underscores the ideal strategies for developing SCOPAs with balanced PDT and PTT. Furthermore, the potential synergies are highlighted between PDT and PTT with other treatment modalities such as ferroptosis, gas therapy, chemotherapy, and immunotherapy. By providing a comprehensive analysis of these strategies, this review aspires to serve as a valuable resource for clinicians and researchers, facilitating the wider application and advancement of SCOPAs‐mediated PDT and PTT.
From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti‐Liver Fibrosis Potential
Authors: Guo Kai , Tang Xue , Liu Yan‐Chun , Cheng Hui‐Zhen , Liu Huan , Fan Yu‐Zhou , Qi Xiao‐Yu , Xu Rui , Kang Juan‐Juan , Li De‐Sen , Wang Guo‐Dong , Gershenzon Jonathan , Liu Yan , Li Sheng‐Hong 
Published: January 2025

AbstractA prolific multi‐product sesterterpene synthase CbTPS1 is characterized from the medicinal Brassicaceae plant Capsella bursa‐pastoris. Twenty different sesterterpenes including 16 undescribed compounds, possessing 10 different mono‐/di‐/tri‐/tetra‐/penta‐carbocyclic skeletons, including the unique 15‐membered macrocyclic and 24(15→14)‐abeo‐capbuane scaffolds, are isolated and structurally elucidated from engineered Escherichia coli strains expressing CbTPS1. Site‐directed mutagenesis assisted by molecular dynamics simulations resulted in the variant L354M with up to 13.2‐fold increased sesterterpene production. These structurally diverse products suggest a comprehensive cyclization mechanism for plant sesterterpenes and provide compelling evidence for the initial cyclization of geranylfarnesyl diphosphate via a crucial 15‐membered monocyclic carbocation. The activities of these sesterterpenes against liver fibrosis is inferred from the inhibition of the transforming growth factor‐β/Smad signaling pathway and collagen synthesis. These findings greatly expand the chemical space and biological functions of sesterterpenes and provide new insights into the catalytic mechanism of terpene synthases.
Modelling Consumers Preferences Using Risk Perceptions and Subjective Knowledge
Authors: Gonçalves Tânia , Lourenço‐Gomes Lina , Pinto Lígia M. Costa , Rebelo João 
Published: January 2025

ABSTRACTLatent class models constitute an alternative approach to the popular mixed logit models to capture sources of individual preference heterogeneity to explain discrete choices. This article applies the latent class model to incorporate random taste variation across individuals or consumers, encompassing the role of lexicographic decision‐making rules in the modeling of discrete choice responses. Furthermore, it provides a deeper understanding of processing information rules, by including latent variables related to individuals' subjective knowledge and risk perceptions in the explanation of the probability of adopting a specific simplifying decision rule or heuristic to select the most preferred alternative. The results reveal that accounting for information processing strategies avoids misspecification bias and yields more plausible behavioral outputs, namely deflated willingness to pay measures. Thus, providing a closer comprehension of the consumers' behavior and choice. These results were derived from a discrete choice experiment applied to a sample of regular wine consumers in Switzerland.
Cure Kinetics and Thermal Recyclability of Epoxy Vitrimer Based on Triple Dynamic Covalent Bonds
Authors: Hao Zengheng , Bo Fu , Wu Yan , Cao Xuejuan 
Published: January 2025

ABSTRACTEpoxy vitrimers have aroused increasing research attention owing to their stable physicochemical properties, recyclability, and reprocessability, and they even achieve rapid self‐healing by the design of multiple dynamic covalent. However, based on the requirement of optimized curing process, research on cure kinetics of multiple dynamic epoxy vitrimer with flexibility is overtly insufficient, compared with single dynamic epoxy vitrimers. Herein, an amine curing agent with imine group (DN) and epoxy with disulfide and β‐hydroxyl ester groups (EP) were synthesized, respectively, and the thermoset epoxy was fabricated from either diglycidyl ether of bisphenol A (E51) or EP cured with DN. The comparison of E51/DN and EP/DN crosslinked network on cure kinetics, mechanical properties, and self‐healing performance was investigated in detail. The activation energy (Ea) of curing reaction for E51D0.25 was low at 31.79 kJ/mol, while EPD0.25 had a higher Ea of 58.81 kJ/mol due to complex reactions. Especially, when the conversion was up to 80%, the Ea of EPD0.25 showed a sharp increment due to the combined effect of crosslinked network and reaction of β‐hydroxyl groups. In terms of performance, compared with single dynamic network (E51D0.25), the flexibility, self‐healing, and recyclability of vitrimer were all improved through introduction of triple dynamic bonds.
Sustaining the “frozen footprints” of scholarly communication through open citations
Authors: Taşkın Zehra 
Published: January 2025

AbstractThis review examines the role of open citations in fostering transparency, reproducibility, and accessibility in scholarly communication. Through a critical synthesis of diverse sources—articles, proceedings, presentations, datasets, and blog posts—it explores the motivations behind citing, the evolving meanings of citations, and key milestones in the open citation movement. Particular attention is given to initiatives like OpenCitations and the Initiative for Open Citations (I4OC), highlighting their contributions to advancing open scholarship. Key findings indicate that open citations democratize research by providing free access to citation data, improving discoverability, and facilitating the creation of public citation graphs. Technological advancements, such as advanced data models and reference mining tools, have significantly contributed to the management and utilization of citation data. Despite these benefits, challenges such as ensuring data quality and standardization, addressing structural inequalities in citation networks, and achieving universal publisher adoption persist. The study concludes with recommendations for future efforts, emphasizing policy advocacy, technological innovation, global collaboration, and educational initiatives to promote the widespread adoption and effective use of open citations. These strategies aim to make the “frozen footprints” of scholarly communication accessible to all, fostering a more equitable and transparent scientific landscape.
Genetic Analyses on Transgender Individuals: Impact on Physician Attitudes and Surgical Decision‐Making
Authors: Cura Duygu Onur , Ülgenalp Ayfer , Çankaya Tufan 
Published: January 2025

ABSTRACTPurposeGenetic studies on the transgender and gender diverse (TGD) community have started to appear in the literature. However, there are limited studies on how genetic data will impact attitudes and perspectives toward TGD individuals. In this study, we investigated the impact of genetic alterations on physicians' attitudes toward TGD individuals and on physicians' decisions concerning gender confirmation surgery (GCS). In this context, we intended to highlight a number of strategies to reduce the inequalities that the TGD community is exposed to in accessing health‐care services.MethodAn online survey including the Turkish version of the Attitudes Toward Transgendered Individuals Scale (ATTIS) was completed by 224 physicians from relevant specialties. Scheffé and least significant difference (LSD) post hoc analysis methods were used to determine physicians' perspectives on whether genetic findings would cause TGD individuals to feel validated/invalidated. Multivariate multinomial logistic regression analysis was employed to assess their responses concerning the decision to perform GCS when genetic alterations had been identified.ResultsMore than half of the physicians expressed the view that genetic analyses for TGD individuals would confer benefits (67.1%). Those who thought that the presence of gender–diversity‐related genetic alterations would have a “positive impact” on their GCS‐related decision to operate were found to have less positive attitudes toward TGD individuals (Bonferroni corrected p < 0.001). Multivariate multinomial logistic regression analysis revealed that age, presenting the odds ratio as the strongest factor, distinguished the “no impact” group from the reference “positive impact” group, particularly among those aged ≤ 35 years (3.299, 95% CI: 1.355–8.033; p = 0.009).ConclusionAlthough genetic analysis of TGD individuals is predicted to have a positive effect on physicians' attitudes toward them and on the GCS decision‐making process, it should be emphasized that the benefits for TGD individuals must outweigh the potential harm. The results showed that physicians need “early and continuing education” to develop a comprehensive perspective on gender identity. The most appropriate approach for genetic testing would be to include the TGD community in decision‐making processes and to develop guidelines for the interpretation of genetic data.
Immune Cells and Intracerebral Hemorrhage: A Causal Investigation Through Mendelian Randomization
Authors: Mo Liumei , Pan Wei , Cao Wenjing , Wang Kui , Huang Li'an 
Published: January 2025

ABSTRACTBackgroundThe involvement of immune cells in the pathophysiology of intracerebral hemorrhage (ICH) is becoming increasingly recognized, yet their specific causal contributions remain uncertain. The objective of this research is to uncover the potential causal interactions between diverse immune cells and ICH using Mendelian randomization (MR) analysis.MethodsGenetic variants associated with 731 immune cell traits were sourced from a comprehensive genome‐wide association study (GWAS) involving 3757 participants. Summary statistics data for ICH were acquired from FinnGen, comprising 4056 ICH cases and 371,717 controls. The principal analytical tool utilized in our study was the inverse‐variance weighted (IVW) method, incorporated as a key component of a two‐sample MR approach. To mitigate potential biases and verify the stability of the conclusions drawn from the primary analytical methods, a series of sensitivity analyses were performed.ResultsMR analysis elucidated 33 immune cell traits with causal associations, comprising B cells (eight traits), conventional dendritic cells (cDC, two traits), maturation stages of T cells (two traits), monocytes (two traits), myeloid cells (five traits), TBNK cells (six traits), and regulatory T cells (Treg, eight traits). DP (CD4+CD8+) %T cell (OR = 0.83, CI = 0.72–0.96, p = 0.013) exhibited the strongest protective effect. In contrast, transitional AC (OR = 1.09, CI = 1.02–1.16, p = 0.006) and IgD− CD27− %lymphocyte (OR = 1.08, CI = 1.00–1.17, p = 0.045) showed a higher tendency to increase the ICH risk. The sensitivity analyses validated the robustness and consistency of these results.ConclusionOur research provides robust evidence substantiating the causal relationship between specific immunophenotypes and ICH risk. The identification of these findings significantly enhances our understanding of the pathogenic mechanisms underlying ICH, particularly pertaining to the immune system. This breakthrough paves the way for innovative clinical and pharmaceutical research opportunities, potentially promoting the development of targeted therapies and enhanced strategies for managing and preventing ICH.
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial
Authors: Chu Tianqing , Zhong Hua , Yu Zhuang , Wang Jing , Zhao Yanqiu , Mu Xiaoqian , Yu Xinmin , Shi Xun , Shi Qingming , Guan Maojing , Ding Cuimin , Geng Nan , Qian Jialin , Han Baohui 
Published: January 2025

AbstractBackgroundThe prognosis for non‐small cell lung cancer (NSCLC) patients treated with standard platinum‐based chemotherapy was suboptimal, with safety concerns. Following encouraging results from a preliminary phase I study, this phase II trial investigated the efficacy and safety of first‐line sintilimab and anlotinib in metastatic NSCLC.MethodsIn this open‐label, randomized controlled trial (NCT04124731), metastatic NSCLC without epithelial growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or proto‐oncogene tyrosine‐protein kinase ROS (ROS1) mutations, and previous treatments for metastatic disease were enrolled. Participants were randomly assigned in a 1:1 ratio to either sintilimab (200 mg every 3 weeks) plus anlotinib (12 mg D1‐14 every 3 weeks) or a standard platinum‐based chemotherapy regimen. Patients in the chemotherapy group were permitted to switch to sintilimab after disease progression. The primary endpoint was the objective response rate (ORR).ResultsFrom November 2019 to March 2023, 99 patients were randomized into the sintilimab plus anlotinib group (n = 49) and the chemotherapy group (n = 50). The ORR was significantly higher in the sintilimab plus anlotinib group (44.9%; 95% confidence interval [CI] = 30.7%‐59.8%) compared to the chemotherapy group (18.0%; 95% CI = 8.6%‐31.4%, P = 0.003). Progression‐free survival (PFS) was also notably longer (median: 14.4 vs. 5.6 months; hazard ratio [HR] = 0.39; 95% CI = 0.23‐0.67; P < 0.001). The 24‐month overall survival rate was 58.4% (95% CI = 40.4%‐72.6%) and 43.2% (95% CI = 26.0%‐59.2%), respectively. The rate of grade 3 or higher treatment‐related adverse events was lower in the sintilimab plus anlotinib group (28.0%) than in the chemotherapy group (49.0%), especially for the hematological toxicities.ConclusionFirst‐line sintilimab plus anlotinib showed improved ORR and PFS, alongside a superior safety profile, compared to the standard platinum‐based chemotherapy for metastatic NSCLC patients.
Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia
Authors: Lazaro‐Navarro Juan , Alcon Clara , Dorel Mathurin , Alasfar Lina , Bastian Lorenz , Baldus Claudia , Astrahantseff Kathy , Yaspo Marie‐Laure , Montero Joan , Eckert Cornelia 
Published: January 2025

ABSTRACTBackgroundCREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug resistance. Anti‐tumor effects have previously been demonstrated for GSK‐J4, a selective H3K27 histone demethylase inhibitor, in several animal models of cancers.MethodsTo characterize the effect of GSK‐J4, drug response profiling, CRISPR‐Dropout Screening, BH3 profiling and immunoblotting were carried out in ALL cell lines or patient derived samples.ResultsHere we provide evidence that GSK‐J4 downregulates cyclic AMP‐responsive element‐binding protein (CREB) and CREBBP in B‐cell precursor‐ALL cell lines and patient samples. High CREBBP expression in BCP‐ALL cell lines correlated with high GSK‐J4 sensitivity and low dexamethasone sensitivity. GSK‐J4 treatment also induced Bcl‐2 and Bcl‐XL dependency and apoptosis.ConclusionsThis study proposes H3K27 demethylase inhibition as a potential treatment strategy for patients with treatment‐resistant ALL, using CREBBP as a biomarker for drug response and combining GSK‐J4 with venetoclax and navitoclax as synergistic partners.
‘Martial Arts Crossed Over Into the Rest of My Life’: A Qualitative Exploration of Australian Practitioners' Experiences of Martial Arts and Combat Sports on Wellbeing
Authors: Healey Gene , Neumann David , Cornell Samuel , Piatkowski Timothy 
Published: January 2025

ABSTRACTMartial arts and combat sports (MA&CS) have emerged as a promising avenue for enhancing health and wellbeing amidst growing concerns about noncommunicable diseases and mental health issues. This study explored the lived experiences of practitioners engaged in modern MA&CS, such as mixed martial arts (MMA), to understand how the practice of modern MA&CS impacts individuals biologically, psychologically and socially. Guided by the Biopsychosocial Model of Health and adopting a social constructivism lens, 16 participants aged 28–55 years underwent semi‐structured interviews, exploring the physiological, psychological and social dimensions of their engagement in modern MA&CS. Through thematic analysis, three overarching themes were developed. The first theme highlighted the role of rigorous training in fostering resilience, discipline and personal growth. The second theme demonstrated how MA&CS builds self‐confidence, reduces aggression and encourages prosocial behaviour. Lastly, the third theme underscored the importance of gym environments in fostering inclusivity, mutual respect and belonging. Modern MA&CS training transcends the gym offering a unique framework that promotes biopsychosocial wellbeing through resilience, confidence and community connection. Modern MA&CS holds potential for educational, therapeutic and community interventions aimed at fostering holistic wellbeing across diverse contexts.
Exploring the Morality of Tax Morale
Authors: Puklavec Žiga , Stavrova Olga , Kogler Christoph , Zeelenberg Marcel 
Published: January 2025

ABSTRACTTax morale, commonly measured as a moral evaluation of cheating on taxes, is important for shaping policy to increase voluntary compliance. Although tax morale is commonly understood as citizens' moral responsibility to pay taxes, there is a dearth of empirical research on whether and how differences in basic morality shape tax morale. Three studies investigated associations between moral ideals, as defined by Moral Foundations Theory, and tax morale. Study 1 (N = 103,474; 57 countries) examined how national differences in moral foundations predict individuals' tax morale. Study 2 (N = 1019) and Study 3 (N = 1001) focused on individual‐level differences. All studies employed multiverse analyses, iterating through multiple combinations of control variables. Despite the apparent semantic similarities between morality and tax morale, consistent empirical connections emerged only with respect to individualising foundations, in particular, fairness. Findings provide first evidence for the role of morality in tax morale, while contributing to a better understanding of why people pay taxes.
Rotational Atherectomy Followed by Modified (Cutting or Scoring) Balloon Versus Plain Balloon Before Drug‑Eluting Stent Implantation for Calcified Coronary Lesions: A Meta‐Analysis
Authors: Khalefa Basma Badrawy , Ayyad Mohammed , Alqeeq Basel F. , Albandak Maram , Ayyad Alaa , Awad Ahmed K. , Gonnah Ahmed R. , Roberts David H. 
Published: January 2025

ABSTRACTCoronary calcification is a major factor leading to stent under‐expansion, and subsequent adverse events. This meta‐analysis aimed to evaluate the short and long‑term outcomes of rotational atherectomy (RA), followed by modified balloon (cutting or scoring) (MB) versus plain balloon before drug‑eluting stent implantation for calcified coronary lesions. We searched PubMed, Web of Science (WOS), Scopus, and the Cochrane Library Central Register of Controlled Trials (CENTRAL), from inception until 30 January 2024. The risk ratio (RR) with a 95% confidence interval (CI) was used to compare dichotomous outcomes, while continuous outcomes were reported in form of mean difference (MD). Our study included seven studies with 309 patients undergoing RA followed by MB angioplasty, and 414 patients had RA followed by conventional plain balloon angioplasty, before stent implantation. Our analysis revealed no significant difference in‐hospital mortality (RR = 0.64, 95% CI [0.18, 2.23], p = 0.49), or long‐term mortality (RR = 0.65, 95% CI [0.18, 2.36], p = 0.51). MACE were significantly lower in the cutting balloon group (RR = 0.58, 95% CI [0.37, 0.92], p = 0.02). Angiographic minimum lumen diameter, and change in percent diameter stenosis were significantly higher in the MB group (MD = 0.19, 95% CI [0.08, 0.31], p = < 0.01), and (MD = 3.75, 95% CI [0.76, 6.74], p = 0.01) respectively. No difference was found regarding target lesion revascularization (RR: 0.50, 95% CI [0.24, 1.04], p = 0.06), or target vessel revascularization (RR: 0.71, 95% CI [0.38, 1.33], p = 0.28). RA followed by MB is as safe plain balloon angioplasty before stent implantation in moderate to severely calcified coronary lesions. Moreover, it is associated with significantly better immediate angiographic outcomes, and significantly lower MACE.