bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Complete Heart Block in a Pregnant Woman Responding to
Steroids: A rare Case Report
Authors: Mahadevappa Manjappa , Patil Soumya , Tripathi Rishi , Ajjammanavar Virupaksha , Kulkarni Prashanth 
Published: February 2023

Background:
Complete heart block (CHB) is the total absence of conduction from atria to ventricles with an escape rhythm most commonly arising from the AVN or His bundle. CHB in pregnancy is very rare, and most reported cases are due to congenital variety, where the pre-existing CHB from birth is either detected incidentally or presented with symptoms during pregnancy. Pregnancy is associated with various physiological changes, such as a pro-inflammatory, hypercoagulable state with possible oedema of the heart's conduction system, which may rarely give rise to CHB. There are no clear guidelines to manage CHB complicating pregnancy.

Case Presentation::
An asymptomatic 27-year-old lady with G2P1L1, 39 weeks of gestation with breech presentation, was referred for delivery given the low maternal heart rate of 40 bpm. Per abdominal examination revealed a term size uterus with active contractions and a fetal heart rate of 140bpm. An ECG revealed a CHB with an escape rate of 40 bpm. Other routine investigations were normal, with negative serological evaluation for hepatitis B, C, and HIV. ANA and Anti-Ro ⁄ SSA antibodies. She underwent an emergency LSCS under spinal anaesthesia with a backup temporary pacemaker (TPM). She received a short course of empirical steroid therapy for three days as there were no obvious secondary causes for CHB, which reverted to sinus rhythm after 48 hours.

Discussion:
CHB complicating pregnancy with or without symptoms may require definitive therapy in the form of permanent pacemaker implantation. However, the insertion of a TPM for managing pregnancy is controversial as opinion in the literature is divided. There are no reports of CHB occurring in pregnancy without congenital or other known acquired causes. In the reported case, the CHB reverted to sinus rhythm with a short course of IV steroid therapy without any subsequent need for a PPM implantation.

Conclusion:
Congenital CHB remains the most common cause of rarely seen CHB complicating pregnancy. Through the conduction system oedema and inflammation, physiological changes in gestation may rarely cause CHB during pregnancy. In the absence of congenital CHB and other demonstrable acquired causes, a short course of steroid therapy may reverse the CHB avoiding PPM implantation as shown in the reported case.
Mechanisms, Copper Catalysts, and Ligands Involved in the Synthesis of 1,2,3-
Triazoles Using Click Chemistry
Authors: Leyva Elisa , Rubén Rodríguez-Gutiérrez Irving , Moctezuma Edgar , Noriega Saúl 
Published: February 2023

Abstract:
In the last two decades, click chemistry has become a modular synthetic procedure
to assemble new molecular structures. It is a powerful methodology that relies on the construction
of carbon-heteroatom bonds of a variety of reactants. In modern synthetic chemistry, it has
been applied in a large number of applications, from pharmaceutical to material science. The
copper-catalyzed 1,2,3-triazole preparation, reacting organic azides with alkynes, has become
the star of click chemistry due to its reliability and biocompatibility. As a consequence, this
reaction has found many applications in diverse areas such as bioconjugation, material science,
and drug discovery. In order to understand the effect of copper catalysts and ligands in click
chemistry, it is important to understand the structural and mechanistic aspects involved. In this
review, several physicochemical aspects of click chemistry are discussed. First, the mechanisms
and intermediates involved in the preparation of 1,2,3-triazoles. Second, the different types of copper catalysts
are used to perform the reaction regioselectively. The last section shows the structure and characteristics of
effective ligands utilized to improve click chemistry under different experimental conditions.
Management of Hemorrhagic Fever Viruses: Intervention of Natural and
Synthetic Products
Authors: Lashgari Naser-Aldin , Roudsari Nazanin Momeni , Khayatan Danial , Samani Nasrin , Eskandari Rad Neda , Mortazavi Morteza , Abdolghaffari Amir Hossein , Momtaz Saeideh 
Published: February 2023

Background:
Viral hemorrhagic fevers (VHFs) are a group of clinical syndromes caused by
several different RNA virus families, including several members of the arenavirus, bunyavirus, filovirus,
and flavivirus families. VHFs have high mortality rates, and they have been associated with vascular
permeability, malaise, fever, variable degrees of hemorrhage, reduced plasma volume, and coagulation
abnormalities. To treat such conditions, antigen-presenting cells target dysregulated immune reactions and
productive infections. Monocytes and macrophages produce inflammatory cytokines that damage adaptive
immunity, while infected dendritic cells fail to mature correctly, compromising adaptive immunity. Inflammation
and uncontrolled virus replication are associated with vascular leakage and coagulopathy.

Objective:
VHF infects both humans and animals and if not treated, causes hemorrhagic manifestations
and lethal platelet dysfunction. Besides pharmacological and immunological solutions, the intervention
of natural products for VHF management is of great interest. In this review, we gathered current
data about the effectiveness of natural products for VHF management.

Methods:
Data were extracted from Scopus, Google Scholar, PubMed, and Cochrane library in terms
of clinical and animal studies published in English between 1981 to February 2022.

Results:
Several plants from diverse families and species were identified with antiviral activity against
VHF. The combination of botanical therapeutics and multitarget synergistic therapeutic effects is now
the widely accepted explanation for the treatment of VHF. Most of these herbal therapeutics have
shown promising immunomodulatory effects in vivo and in vitro VHF models. They can probably
modulate the immune system in VHF-infected subjects mainly by interfering with certain inflammatory
mediators involved in various infectious diseases.

Conclusion:
Natural, in particular, herbal sources can be valuable for the management of various
VHFs and their related complications.
Survival of Persons Living With HIV/AIDS: A Multicentric Study From
India
Authors: Sinha Sanjeev , Abdul  Samad Sameer , Bansal Garima , Verma Saurav , Sangle Shashikala Anant , Guha Subhasish Kamal , Rajput Neetu , Pandey Ravindra Mohan , Ranjan Sanjay , Salvi Sonali , Mundhe Sanjay , More Monika , Modak Dolanchampa , Datta Kalpana , Kabra S.K. , Lodha Rakesh , Nischal Neeraj , Das Bimal Kumar 
Published: February 2023

Background:
It has been more than 17 years since the introduction of free ART in India.
At this point, it would be prudent to look at the factors associated with the survival of persons living
with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA)
who are already enrolled in the ART program.

Methods:
PLHAs enrolled from antiretroviral therapy (ART) centers located in three different cities
in India – Delhi, Pune and Kolkata, and were followed up at six monthly intervals monitoring the
WHO stage, CD4 counts, complete blood counts, and liver and kidney function tests, for a duration
of three years.

objective:
Monitoring the WHO stage, CD4 counts, complete blood counts and liver and kidney function tests, for a duration of three years

Results and Discussion:
The incidence of mortality among HIV/AIDS patients on ART was 5·0 per
1000 patient-years (21/1410, 1.4%). Age at initiation of ART, being above 35 years, was the only
significant predictor of mortality (log-rank p = 0·018). Multivariable analysis showed a significant
association of an unfavourable outcome (defined as mortality or development of opportunistic infection
during follow-up) with male gender (adjusted odds ratio (AOR) = 5.26, p = <0.01) and being
unmarried at ART initiation (AOR = 1.39, p = 0.005).

Conclusion:
The survival of PLHA with good adherence to ART is independent of the WHO stage
or CD4 counts at the initiation of ART. Initiation of ART after 35 years of age was a significant
predictor of mortality.

conclusion:
The survival of PLHA with good adherence to ART is independent of the WHO stage or CD4 counts at initiation of ART.
Synthesis Memantine and Memantine Hydrochloride by Direct Amination
of 1-Bromo-3,5-dimethyladamantane with Thiourea
Authors: Vu Binh Duong , Phan Dinh Chau , Nguyen Thi Hong Tham , Nguyen Thi Hong Thanh , Luong Quang Anh , Ngo Thi Xuan Thu 
Published: February 2023

Abstract:
Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA
for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of
memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea.
The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction
was 5.5 hours, the temperature reaction in the first stage was 160oC and in the second stage was
80oC; the overall yield was 82.44%. The reaction intermediates were confirmed by the IR, MS,1HNMR,
and 13C-NMR spectra.
Recommendation to Consume Plant Products for their Health Benefits
may Take a Different Perspective with Global Warming
Authors: Sak Katrin 
Published: February 2023

Abstract:
Over the past few decades, the multifaceted anticancer action of various plant-derived
flavonoids has been demonstrated both in in vitro and in vivo preclinical experiments as well as
in clinical trials and large-scale epidemiological studies. These secondary metabolites, synthesized
in plants in response to different environmental stresses, can exert diverse biological activities
in the human body after ingestion of plant-based foods. Flavonoids are indeed well-known
for their antioxidant, anti-inflammatory, antiproliferative, proapoptotic, anti-migratory, antiinvasive,
anti-metastatic, and anti-angiogenic properties, thereby preventing and slowing the development
of different types of human cancers. Accordingly, more and more people all over the
world have increased their everyday intake of fruits, vegetables, whole grains, and spices to get
the benefits of flavonoids. In this commentary article, a critical view is presented on the possible
gradual decrease in the health-promoting effects of edible and medicinal plant products related to
changes in their flavonoid content and composition as a consequence of global warming. It is indeed
generally accepted that biosynthesis and accumulation of certain flavonoids can be higher
in plants cultivated in colder conditions, while a high temperature may even block the production
of these agents. It only remains to be determined in the future as to what extent the lowering of
flavonoids content in plant-based diets during global warming can contribute to continuously increasing
worldwide incidence of new cancer cases, revealing the actual costs of human-induced
environmental changes.
Maternal, Fetal and Neonatal Outcomes in Pregnant Women with
COVID-19: A Case-Control Study
Authors: Sattari Mahtab , Samari Banafshe , Beheshti Rezvanehsadat , Farhadian Maryam , Tiznobaik Azita , Sepahvand Saba 
Published: February 2023

Background:
COVID-19 is an emerging, highly contagious disease caused by the SARSCoV-
2 virus. Pregnant women appear to be at greater risk for COVID-19 infection and complications.
Considering the importance of maternal and fetal healthcare, this study aims to evaluate some of the
maternal, fetal, and neonatal outcomes in pregnant women with COVID-19.

Methods:
Pregnant women at the gestational age of 20 weeks or more were recruited and divided into
two groups: cases (those with COVID-19 infection) and controls (those without the infection). Maternal
complications during the current pregnancy, delivery factors, and fetal/neonatal complications
were recorded and compared between the groups.

Results:
Maternal COVID-19 infection was highly associated with the need for emergency cesarean
surgery (p = 0.005), preterm labor (p = 0.017), and the need for NICU admission for newborns (OR =
0.05, p = 0.000). Also, high rates of vertical transmission of the infection were observed in the cases.

Conclusion:
Maternal COVID-19 disease could be associated with a range of complications for both
the mother and her newborn. The vertical transmission rate was also observed to be higher than previously
reported in the literature. Further studies are required to evaluate this phenomenon.
Design, Synthesis, Molecular Docking, and Preliminary Pharmacological
Screening of some New Benzo[d]thiazol-2-ylamino Containing Chromen-2-
one Derivatives with Atypical Antipsychotic Profile
Authors: Gawai Ashish A. , Biyani Kailash R. , Das Sanjib , Tapadiya Ganesh G. , Mokale Santosh N. , Dhawale Sachin A. 
Published: February 2023

Introduction:
Mental disorders are very serious complicated disorders. Schizophrenia
is one of the most baffling mental disorders. The new series 7-(2-(benzo[d]thiazol-2-
ylamino)ethoxy)-4-methyl-2H-chromen-2- synthesized in search of newer compounds for Schizophrenia.

Methods:
Synthesis is done by refluxing in dry pyridine with various substituted 2-amino benzothiazoles
derivatives (3a-3k) and 7-(2-Chloroethoxy)-4-methyl-2H-chromen-2-one (2). The molecular
docking approach was used to screen these generated derivatives. Chem Bio Draw Ultra 12
was used to draw the compounds, which were then exposed to all potential conformations of compounds
interacting with receptors. The Glide 7.6, Schrodinger 2017 Maestro 11.3 was used to
achieve molecular docking. The Dopamine receptor 6CM4 serotonin 5TUD PDBs were acquired
from the database of Brookhaven Protein. Using the OPLS 2005 force field, the ligand-protein
hydrogen-bond network was acquired, along with the overall energy reduced. A glide score was
used to rate the docking poses.

Results:
The produced compounds have been identified with the use of analytical and spectral
data. All of the produced substances were tested and analyzed for serotonin 5HT2 antagonistic and
dopamine D2 activity, which can be considered as a measure of typical antipsychotic properties.

Conclusion:
Compounds 4b, 4c, 4e, 4g & 4i have demonstrated promising pharmacological action
in preliminary studies. According to the preceding findings, compounds with electronwithdrawing
substitutions, such as 4e & 4b, have a good atypical profile of antipsychotics.
Yellow Fever Vaccination in Hemodialysis Patients: A Systematic Review
Authors: Figueiredo Vidal Emery Ciana , da Veiga Glaucia Luciano , Rodrigues Bacci Marcelo , Figueiredo Vidal Eglidia Carla , da Costa Aguiar Alves Beatriz , Gascon Thais , Affonso Fonseca Fernando Luiz 
Published: February 2023

Introduction:
Yellow fever is an infectious disease endemic to Africa, and Central and
South America with a significant impact on public health, causing outbreaks and epidemics. Clinical
manifestations can vary from asymptomatic to more severe and lethal disease outcomes. The primary
prevention of yellow fever occurs through the vaccination of individuals, which confers immunity for
life. Patients with chronic kidney disease, especially those undergoing dialysis, have low vaccination
and seroconversion rates. As mentioned above, this research aimed to perform a systematic review of
the yellow fever vaccination protocol in hemodialysis patients.

Methods:
A systematic review on vaccination against yellow fever in hemodialysis patients using databases,
PubMed and Biblioteca Virtual em Saúde (BVS), was performed. For data collection, combinations
were made using the following descriptors: protocols, vaccination, yellow fever, kidney dialysis,
chronic kidney failure, chronic kidney disease, and group risk included in the title and abstract description.
Articles with no subject related to the search were excluded and also if they were duplicated.

Results:
In this review, 90 scientific articles were identified in both databases. After applying exclusion
criteria, a total of 3 articles were selected.

Conclusion:
We recommend carefully assessing the risk-benefit and contraindications for the patient,
emphasizing the risk groups. There is an evident lack of studies on the subject, and there is a need to
broaden investigations related toimmunization for patients on dialysis. The review is registered in the
PROSPERO system with the number 323550.
Optimization of Hormonal Compositions of Media for In vitro Propagation of Apple (Malus ×domestica Borkh.) Cultivars
Authors: Abdella Bona , Yusuf Zekeria , Petros Yohannes 
Published: February 2023

Background:
Apple (Malus × domestica Borkh.) is one of the most important fruit crops in the world. Traditionally, vegetative propagation methods (including cutting, budding, and layering) are time-consuming (about three years), with low production rates and low success in obtaining virus-free plants.

Objective:
The present study was planned to investigate the in vitro propagation of apple (M. domestica) cultivars from nodal segments.

Methodology:
The Murashige and Skoog (MS) medium supplemented with sucrose and different concentrations of plant growth regulators (PGRs) were used for shoot proliferation and root induction. The optimal concentrations of PGRs in the MS medium were assessed. The effect of full and half-strength MS medium on root induction was investigated.

Results:
Examination of the effects of MS medium supplemented with various concentrations of indole-3-acetic acid (IAA) and kinetin revealed that the significantly highest shoot response was recorded for the ‘Princess’ cultivar with maximum shoot proliferation rate (65.25%), shoot number per explant (2.57), shoot length (7.28cm), and leaf number per shoot (6.15) after four weeks of culture. The root induction in micro shoots of three apple cultivars was observed after 20 days of culturing. The strength MS medium (full and half) containing 1.5 mg/L IAA significantly affected (at P<0.05, chi-square test) root induction in all three apple cultivars, especially rooting rate. However, there was no significant difference in root number and root length per micro shoot among the apple cultivars. Among the cultivars, significantly the highest rooting rate(48.30%), root number (6.25), and root length (4.15cm) were recorded for cultivar ‘Princess’ on full-strength MS medium.

Conclusion:
PGR combination of IAA (1.0 mg/L) and kinetin (3.0 mg/L) was found to be the best for shoot proliferation. The shoot responses were found to increase with an increase in kinetin concentration combined with IAA at 1.00 mg/L.
Compressive Strength Dependency on the Effect of Temperature Variation on the Percentages of Steel Fiber in Concrete
Authors: Emiri Dafe Aniekan , Chiadighikaobi Paschal Chimeremeze , Ng’andu Prosper 
Published: February 2023

Aims:
The aim of this study is to check the effectiveness of steel fiber on the compressive strength of concrete.

Background:
Fibers have long been used as building materials to improve the ductility, tensile, compressive, and flexural strengths of concrete. Although fibers have been known as an effective reinforcement material for concrete structures, it is also acknowledged to be a suitable alternative to reinforcement steel bars.

Objective:
The objective of this research is to investigate some engineering properties, the compressive behavior of steel fiber reinforced concrete (SFRC), and the effect of elevated temperatures of up to 1000°C on concrete.

Methods:
Various tests which included the slump test, compressive strength test, as well as heating tests were done. The workability (slump) and thermal effects of M20 SFRC were evaluated.

Results:
Based on the results obtained, it could be observed that the workability of the M20 concrete reduced with the increase in steel fiber (SF) content from 0% to 1.6% as values obtained were 80mm, 73mm, 67mm, 61mm and 55mm for SF contents of 0%, 0.4%, 0.8%, 1.2%, and 1.6% respectively. These values showed medium workability of the concrete according to ASTM C-143/C-143 M-03. Also, the addition of SF to plain M20 concrete greatly improved the compressive strength (ƒc) with the concrete strength at 26.89N/mm2, 30.41N/mm2, 32.85N/mm2, 35.90N/mm2 and 39.66N/mm2 after 28 days of curing for steel fiber contents of 0%, 0.4%, 0.8%, 1.2%, and 1.6% respectively. The f_c after heating the concrete mix to 1,000°C showed improved thermal resistance with 4.2N/mm2, 8.23N/mm2, 11.63N/mm2, 15.60N/mm2 and 17.20N/mm2 for SF contents of 0%, 0.4%, 0.8%, 1.2% and 1.6% respectively.

Conclusion:
The incorporation of steel fibers in the concrete mix decreased the workability of SFRC but increased its compressive strength and balling tendencies.
Bioactive Furanocoumarin 'Alloimperatorin': Therapeutic Importance and
Pharmacological Activities in Medicine
Authors: Patel Dinesh Kumar 
Published: February 2023

Background:
Plants and their derived phytochemicals commonly called secondary metabolites have been used in medicine as a good source of medicine for the treatment of numerous kinds of human disorders and associated complications. Herbal medicines have been used in modern medicine for the treatment of some chronic disorders, including cancer. Coumarins class phytochemicals are important in medicine and mainly derived from plant sources, including Angiosperms. Coumarins have numerous biological activities including antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant, anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, and anti-depressive.

Methods:
Here in the present work, numerous scientific data were collected from different scientific databases and analyzed in order to know the biological potential of alloimperatorin in medicine. Google, Google Scholar, PubMed, and Scopus databases were searched and analyzed to know the medicinal properties and therapeutic potential of alloimperatorin. Therapeutic potential of alloimperatorin was investigated in the present work through scientific data analysis of different scientific research work. Pharmacological activities of alloimperatorin were analyzed in the present work to know the beneficial health aspects of alloimperatorin against various forms of human disorders.

Results:
Scientific data analysis of different research work revealed the therapeutic potential of alloimperatorin in medicine. Alloimperatorin is a coumarin class phytochemical found in the Angelica dahurica. Alloimperatorin revealed significant therapeutic potential in medicine mainly due to its anti-oxidative, anti-inflammatory, anti-apoptotic potential, however its biological potential in breast cancer and their photosensitization effect were also discussed in the present work. Analytical data signified the presence of alloimperatorin in different medicinal plants.

Conclusion:
Present work signified the biological importance and therapeutic potential of alloimperatorin in medicine.