bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between fear of progression and sleep quality in patients with chronic heart failure: A cross‐sectional study
Authors: Xiong Juanjuan , Qin Jingwen , Gong Kaizheng 
Published: March 2023

AbstractAimsThis study aimed to measure sleep quality and its possible association with fear of progression (FOP) in patients with chronic heart failure (HF).DesignA cross‐sectional study.MethodsA total of 254 patients with chronic HF were recruited from two tertiary hospitals in China. The sociodemographic and clinical data of participants were collected using a general information questionnaire. The Pittsburgh Sleep Quality Index and Fear of Progression Questionnaire‐Short Form were used to evaluate sleep quality over 1 month and FOP. Pearson correlation and hierarchical regression were conducted to analyse the relationship between sleep quality and FOP.ResultsOf all participants, 85.8% had poor sleep quality, with a mean score of 12.3 ± 4.2 (possible score could be 0 to 21). The severity of FOP was positively correlated with poor sleep quality. HF hospitalization in the past year, numbers of HF drugs, monthly income and total score of FOP were strong predictors of decreased sleep quality, accounting for 24.2% of the variance in the sleep quality of these patients.ConclusionsPatients with chronic HF generally reported poor sleep quality, which should be highly concerned for medical workers. Alleviating FOP as a therapeutic strategy may improve sleep quality.ImpactIt is urgent to raise clinical attention that Chinese patients with chronic HF have poor sleep quality, which is not just due to the symptoms of HF itself. FOP is an important psychological factor influencing sleep quality in patients with chronic HF, which has not been explored in China. This study provides a new perspective on targeted interventions for poor sleep quality in chronic HF.Patient and public involvementNo patient or public involvement.
Study of medication use and effects of medication among hospitalized older Buddhist monks: An embedded mixed‐method study
Authors: Chisana Noppasin , Banharak Samoraphop , Panpanit Ladawan , Chanaboon Sutin , Tipkanjanaraykha Kitsanaporn 
Published: March 2023

AbstractAimThe aim was to study medication use, effects of medication and perspective of participants involved in medication use among hospitalized older Buddhist monks.DesignAn embedded mixed‐method study.MethodsThis study included 71 hospitalized older Buddhist monks and 23 participants involved in medication use. Quantitative data were collected from medical and medication records. Meanwhile, qualitative data were collected by using in‐depth interviews. Data were analysed using descriptive statistics and content analysis. The study lasted from February to July 2021.ResultsOver 77% of the monks had chronic diseases. The median of medicine use was seven medicines/person and 6 days of use. Effects of the medication were as expected (52.04%), not as expected (2.22%) and unmeasurable results (45.74%). Unexpected results were hypo‐hyperglycaemia, nausea/vomiting, high blood pressure and confusion. From the interview, participants perceived and did not perceive unique practices and medication use in Buddhist monks. In addition, the Buddhist monks received medication following standards and Buddhist doctrine. Finally, recommendations for medication use were adhering to the standard, following Buddhist doctrine and being flexible as deemed necessary.ConclusionThe results revealed medication use problems and medication effects among hospitalized older Buddhist monks.ImpactOlder adults and Buddhist monks have specific needs and practices related to culture and religion, affecting typical treatment, especially medication use. Cultural diversity and sensitivity should be a concern for healthcare staff. The results can be utilized to promote an understanding of cultural diversity and increase the safety of medication administration for hospitalized older Buddhist monks.Patient and Public ContributionPatient and public contributions were involved in this study. Participants involved in medication use were interviewed to answer the research objective. Moreover, a senior Buddhist monk at Wat Thai Washington D.C. reviewed content related to the Pali Canon for the final draft of the manuscript.Clinical Trial Registration Number
https://osf.io/b6p3e
The relationships of plant species occupancy to niches and traits vary with spatial scale
Authors: Mod Heidi K. , Rissanen Tuuli , Niittynen Pekka , Soininen Janne , Luoto Miska 
Published: March 2023

AbstractAimSupport for different underlying mechanisms of species occupancy is inconsistent, yet this could be related to spatial scale. Since abiotic filtering typically acts at broader scales than biotic interactions, we hypothesise that occupancy could be more driven by species' abiotic niche (i.e. tolerance and preference of abiotic conditions) at broad scales, whereas species' traits affecting competitive ability could be more important at fine scales. Here, we test these hypotheses by assessing relationships of occupancy to niche and trait metrics across spatial scales.LocationFour study areas located north of Arctic Circle.TaxonVascular plants.MethodsWe derived occupancy for 106 species at four spatial scales (micro‐scale with plot size of 0.04 m2 and extent of 2 km, local‐scale with plot size of 4 m2 and extent of 40 km, regional‐scale with plot size of 4 ha and extent of 800 km, and polar‐scale with plot size of 4 km2 and extent of 5200 km). We then assessed using generalized additive models whether the relationships between occupancy and species' niche breadth, niche marginality, intraspecific trait variability (ITV) and trait distinctiveness vary across the scales.ResultsAt the finer scales, ITV (especially of specific leaf area) had the highest contribution with positive relationship in explaining occupancy. At the broader scales, occupancy was better explained by niche metrics. Especially at the broadest scale, the occupancy had a positive relationship with species' climatic tolerance.Main ConclusionsAbiotic filtering, especially related to macro‐climate, drives species occupancy at broader spatial scales while biotic interactions are relatively more important at local scales. This scale‐dependency of factors behind species occupancy should be accounted for when, for example, planning conservation of rare species, forecasting invasions or anticipating the effects of changing climate on biota at local versus global scales.
Insulin‐like growth factor 1 ameliorates pre‐eclampsia by inhibiting zinc finger E‐box binding homeobox 1 by up‐regulation of microRNA‐183
Authors: Lai Weisi , Yu Ling 
Published: March 2023

AbstractAs a common hypertensive complication of pregnancy, preeclampsia (PE) remains one of the leading causes of maternal and fetal with high morbidity and mortality worldwide. Much research has identified the vital functions of insulin‐like growth factor 1 (IGF‐1) in PE treatment. However, the combined roles and molecular mechanism of IGF‐1 and microRNAs (miRNAs) underlying PE remain unclear. Therefore, we first measured the expression of IGF‐1, zinc finger E‐box binding homeobox 1 (ZEB1) and microRNA‐183 (miR‐183) expression in the placenta tissues of patients with PE by Western blot analysis and RT‐qPCR. Interactions among IGF‐1, ZEB1 and miR‐183 were assessed by Western blot analysis, ChIP‐PCR and dual‐luciferase reporter gene assay. The effect of IGF‐1 on the biological characteristics of trophoblast cells was investigated by CCK‐8, colony formation assay and in vitro angiogenesis experiments after cells were transfected with si‐IGF‐1. Finally, a mouse eclampsia model induced by knockdown of IGF‐1 was established to confirm the in vitro effect of IGF‐1 on PE. We found that IGF‐1, ZEB1 and miR‐183 were highly expressed in the placental tissues of patients with PE. The knockdown of IGF‐1 resulted in reduced proliferation and invasion of trophoblast cells and was accompanied by inhibited angiogenesis. ZEB1 was positively regulated by IGF‐1 via ERK/MAPK pathway, which in turn inhibited miR‐153 expression by binding to the miR‐183 promoter. The in vitro experiments further confirmed that IGF‐1 knockdown could induce PE. To sum up, IGF‐1 knockdown elevated expression of miR‐183 by downregulating ZEB1, thereby promoting deterioration of PE.
The Revolving Door and Access to the European Commission: Does the Logic of Influence Prevail?
Authors: Belli Sharon S. , Beyers Jan 
Published: March 2023

AbstractThis article analyses to what extent and under which conditions revolving door practices relate to access to the European Commission (EC). The revolving door hypothesis is analysed by combining two data sources: a dataset with publicly available records about the meetings between interest organizations and senior EC officials and evidence collected through the Comparative Interest Group‐survey (CIG‐survey). It is especially in professionalized organizations, where staff and organizational leadership dominate, that we observe a significant positive relationship between revolving door practices and access. In contrast, the extent to which the membership decides on political positioning and advocacy strategies has no impact on the relationship between revolving door and access. These results show that the revolving door is primarily connected with a logic of influence, implying that revolvers are especially advantageous for professionalized organizations.
Network analysis of ecological momentary assessment identifies frustration as a central node in irritability
Authors: Tseng Wan‐Ling , Naim Reut , Chue Amanda , Shaughnessy Shannon , Meigs Jennifer , Pine Daniel S. , Leibenluft Ellen , Kircanski Katharina , Brotman Melissa A. 
Published: March 2023

BackgroundIrritability presents transdiagnostically, commonly occurring with anxiety and other mood symptoms. However, little is known about the temporal and dynamic interplay among irritability‐related clinical phenomena. Using a novel network analytic approach with smartphone‐based ecological momentary assessment (EMA), we examined how irritability and other anxiety and mood symptoms were connected.MethodsSample included 152 youth ages 8–18 years (M ± SD = 12.28 ± 2.53; 69.74% male; 65.79% White) across several diagnostic groups enriched for irritability including disruptive mood dysregulation disorder (n = 34), oppositional defiant disorder (n = 9), attention‐deficit/hyperactivity disorder (n = 47), anxiety disorder (n = 29), and healthy comparisons (n = 33). Participants completed EMA on irritability‐related constructs and other mood and anxiety symptoms three times a day for 7 days. EMA probed symptoms on two timescales: “since the last prompt” (between‐prompt) versus “at the time of the prompt” (momentary). Irritability was also assessed using parent‐, child‐ and clinician‐reports (Affective Reactivity Index; ARI), following EMA. Multilevel vector autoregressive (mlVAR) models estimated a temporal, a contemporaneous within‐subject and a between‐subject network of symptoms, separately for between‐prompt and momentary symptoms.ResultsFor between‐prompt symptoms, frustration emerged as the most central node in both within‐ and between‐subject networks and predicted more mood changes at the next timepoint in the temporal network. For momentary symptoms, sadness and anger emerged as the most central node in the within‐ and between‐subject network, respectively. While anger was positively related to sadness within individuals and measurement occasions, anger was more broadly positively related to sadness, mood lability, and worry between/across individuals. Finally, mean levels, not variability, of EMA‐indexed irritability were strongly related to ARI scores.ConclusionsThis study advances current understanding of symptom‐level and temporal dynamics of irritability. Results suggest frustration as a potential clinically relevant treatment target. Future experimental work and clinical trials that systematically manipulate irritability‐related features (e.g. frustration, unfairness) will elucidate the causal relations among clinical variables.
Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus
Authors: Wang Lina , Dong Shanshan , Zhao Chenxu , Gao Zhaoyu , Jiang Lei , Zhang Rui , Shen Tingting , Guo Yingying , Zhou Huimin , Xu Shunjiang 
Published: March 2023

AbstractAims/IntroductionThis study was carried out to investigate the relationship of stressful life events (SLEs) with the risk of cognitive impairment in patients with type 2 diabetes mellitus.Materials and MethodsA total of 316 patients with type 2 diabetes mellitus aged >45 years were recruited in this study, and data on demographics, medical history, lifestyle characteristics and SLEs were collected. The cognitive status of patients was evaluated with a battery of cognitive function scales. Logistic regression analyses were carried out to evaluate the risk and protective factors for mild cognitive impairment (MCI).ResultsParticipants, including 217 type 2 diabetes mellitus patients with MCI and 99 patients without MCI, were enrolled in the current study. Among the SLEs, the death of an offspring or parent (odds ratio [OR] 1.994, 95% confidence interval [CI] 1.017–3.908) was a risk factor for MCI after adjustment for age and education level. In the subgroup of participants aged <60 years, the death of an offspring or parent (OR 2.731, 95% CI 1.119–6.665) and financial difficulty (OR 22.205, 95% CI 4.365–112.966) were risk factors for the development of MCI, whereas high working pressure (OR 0.154, 95% CI 0.048–0.495) and career changes (OR 0.324, 95% CI 0.124–0.847) were protective factors for MCI.ConclusionsThese data suggested that SLEs were associated with cognitive function in patients with type 2 diabetes mellitus. Adverse life events, such as the death of an offspring or parent, were risk factors for cognitive impairment, whereas high work pressure in middle‐aged people was a protective factor against cognitive impairment.
Safety of baclofen versus tizanidine for older adults with musculoskeletal pain
Authors: Su Zhang Vanessa R. , Niu Fang , Lee Eric A. , DiStasio Christopher , Broder Benjamin I. , Steinberg Steven G. , Hui Rita L. 
Published: March 2023

AbstractBackgroundBaclofen and tizanidine are both muscle relaxants that carry the risk for neuropsychiatric events in older adults but there is a lack of data directly comparing their safety. This study aimed to investigate the relative risk between these two medications in causing injury and delirium in older adults.MethodsThis was a retrospective cohort study that was completed in an integrated healthcare system in the United States and included patients aged 65 years or older who started baclofen or tizanidine for the treatment of musculoskeletal pain from January 2016 through December 2018. Outcomes included new incidence of injury (concussion, contusion, dislocation, fall, fracture, or other injuries) and delirium. The cohort was followed from the initiation of therapy until the first occurrence of any of the following events: end of the index drug exposure, end of health plan membership, death, or the study end date of December 31st, 2019. Descriptive statistics were used to compare baseline patient characteristics between baclofen and tizanidine treatment groups. Cox proportional hazards model was used to calculate adjusted hazard ratios (HRs) with 95% confidence intervals.ResultsThe final study cohort included 12,101 and 6,027 older adults in the baclofen and tizanidine group respectively (mean age 72.2 ± 6.2 years old, 59% female). Older adults newly started on baclofen had a greater risk of injury (HR = 1.54, 95% CI = 1.21–1.96, P = < 0.001) and delirium (HR = 3.33, 95% CI = 2.11–5.26, p = <0.001) compared to those started on tizanidine.ConclusionThe results of this study suggest that baclofen is associated with higher incidences of injury and delirium compared to tizanidine when used for the treatment of musculoskeletal pain. Future studies should investigate if these risks are dose‐related and include a comparison group not exposed to either drug.
Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome‐gut‐brain axis
Authors: Pawluski Jodi L. , Murail Pauline , Grudet Florine , Bys Lena , Golubeva Anna V. , Bastiaanssen Thomaz , Oberlander Tim F. , Cryan John F. , O'Mahony Siobhain M. , Charlier Thierry D. 
Published: March 2023

AbstractSelective serotonin reuptake inhibitors (SSRIs) are the most popular antidepressant medications used to manage perinatal mood disturbances, yet our understanding of how they affect the microbiome‐gut‐brain axis of the mother and offspring is limited. The purpose of this study was to determine how peripartum SSRI treatment may prevent the effects of gestational stress on plasticity in the maternal hippocampus, plasticity in the neonatal brain and related changes in gut microbiota. To do this Sprague–Dawley female rats were left untreated or subjected to unpredictable stress during pregnancy. Half of the females were supplemented daily with fluoxetine. On postpartum day 2 brains were collected for measurement of plasticity (neurogenesis and microglia content) in the maternal hippocampus and in the neonatal brain. Glucocorticoid receptor density was also investigated in the maternal hippocampus. Microbiota composition was analyzed in fecal samples of dams during and after pregnancy, and colon tissue samples from offspring on postnatal day 2. Main findings show there are significant changes to the maternal microbiome‐gut‐brain axis that may be fundamental to mediating plasticity in the maternal hippocampus. In addition, there is significant impact of gestational stress on neonatal gut microbiota and brain microglia density, while the effects of SSRIs are limited. This is the first study to explore the impact of gestational stress and SSRIs on the microbiome‐gut‐brain axis in the mother and neonate. Findings from this study will help inform pathways to intervention strategies including stress reduction techniques and/or microbiota targeted nutritional approaches directed towards improving maternal gut health and outcomes for mother and neonate.
Balancing evolutionary impulses: Effects of mindfulness on virtue food preference
Authors: Errmann Amy , Septianto Felix 
Published: March 2023

AbstractMindfulness is emerging as a contemplative tool that may positively influence consumers' preference for virtue food, thus supporting health and well‐being. However, it remains unclear which consumer groups may benefit the most from mindfulness. Previous research has demonstrated that consumers who experienced unpredictable environments in low socioeconomic households as children exhibit the likelihood of an adaptive chronic preference for vice food. Against this backdrop, the current research explores how mindfulness can support consumers who experienced low socioeconomic environments as children and further sheds light on the psychological mechanism, reduced impulsivity, for increased virtue food choice. This effect is tested across different manipulations of mindfulness and virtue food contexts. The research also introduces the unique mindfulness intervention of object visualization for helping stabilize the present‐moment for consumers. Overall, the findings show that mindfulness may be a potential solution to impulsivity and increase preference for virtue food, supporting consumers in health and well‐being.
Financial resilience of two‐worker households from a health perspective
Authors: Yao Rui , Xu Yilan , Zhang Jie 
Published: March 2023

AbstractThe COVID‐19 pandemic highlighted the significant impact of health conditions on household finance. Traditional measures of financial resilience ignored households' ability to adjust to labor income disruptions. We proposed a more comprehensive two‐tier measure of financial resilience by accounting for nonlabor income and spending adjustments in the face of income loss associated with health situations. Using this measure, we evaluated the financial resilience of two‐worker households with members having COVID‐19 health risk conditions and other mental and physical chronic diseases. Our findings showed that households with cancer patients were more financially resilient yet those having obese members were less financially resilient. Decomposition of the financial resilience measure revealed differences in financial resources allocation—households with cancer patients allocated more wealth to noncash financial assets, whereas households with obese members saved less and spent more. Our findings shed light on financial planning practices and public policies of emergency assistance.
The evolving field of regenerative aesthetics
Authors: Goldie Katherine 
Published: March 2023

AbstractBackgroundRegenerative aesthetics (RA) is an emerging subfield based on many of the principles of regenerative medicine (RM). In order to ensure that the development of regenerative aesthetics is based on accepted regenerative concepts and to optimize treatment strategies, it is important to establish clear definitions, fundamental aims and consider the impact of the predominant RA tissue environment RM focuses on the regeneration of injured or diseased tissue, while RA aims to restore youthful properties to aging, senescent tissue. The distinction is key in understanding how best to develop treatments for these different goals.Aims and methodsThe current review suggests key concepts, definitions, and foundations of regenerative aesthetic approaches and examines current evidence supporting this. It considers the importance of the aging tissue environment, the essential regenerative goals of restored tissue structure and function and introduces the concept of regenerative scaffolds with a focus on CaHA. Current techniques in the field and promising future directions are also discussed.ConclusionRegenerative aesthetics is an evolving subfield of regenerative medicine. Establishing clear definitions, identifying the challenges of the aging soft tissue environment and re‐evaluating current evidence in light of regenerative goals are vital for the continuing evolution of this medical field.