bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengaruh Faktor Eksternal dan Internal Terhadap Tingkat Permintaan Sukuk Ritel SR008
Authors: Anzal Cupian , Al Ayyubi Muhammad Ikhwan , Hasanah Alfiah 
Published: May 2023

Sukuk Retail SR008 was issued in 2016 as one of instrument to finance government deficit in spending . Sukuk Retail SR008 reported to have the largest number of investors and total issuance in the history of retail sukuk in Indonesia. This study investigates the effect of internal and external variables on the trading volume of retail sukuk SR008 in the short and long term. Using a montly data from June 2016 to February 2019 and use the Vector Error Correction Model (VECM), the independent variables used in this study are, retail sukuk SR008 price and yield, ORI013 retail bond price, mudhorabah profit sharing for one month, and GDP level. The results show that price sukuk retail SR008, yield sukuk retail SR008 and PDB have a positive and significant effect on the trading volume of retail sukuk SR008 in the longrun however variable share rate of mudhorabah one-month and price bond retail ORI013 have negative effect . In the short run, all independent variables have no significant effect on the retail sukuk SR008 trading volume.
Medication review with follow-up service by community pharmacists forpatients under treatment with coumarin anticoagulants in collaboration with Primary Care
Authors: Sáez-Benito Ana , Sáez-Benito Loreto , Oliván Bárbara , Magallón Rosa , Ezquerra Leyre , Berenguer Nuria 
Published: May 2023

Abstract
Introduction: Anticoagulation treatment with VKA presents an optimal risk-benefit balance in patients with a Time in Therapeutic Range (TTR) >70%. Pharmacist integration in the primary health care team, using innovative tools such as the SAME-TT2R2 and pharmacogenetics information, could enhance the management of anticoagulated patients. This study aims to assess the effectiveness of a medication review with follow up service by community pharmacists, in collaboration with Primary Care for patients treated with VKA.
Methods and analysis: A randomized controlled study with blinded outcome assessment will be conducted. Patients treated with VKA with TTR<70% from 2 health care centres will be included. Primary outcome is TTR during last 6 months. Secondary outcomes will be: adherence, vitamin K intake, patient’s knowledge, pharmacogenetics and SAME-TT2R2’s clinical utility, costs, quality of life and satisfaction. Potential clinical, economic, and humanistic impact of the interventions will be retrospectively analysed using CLEO tool. Intervention group will receive a medication review with follow up, physicians will receive an evidence-based report patient´s medicine-related problems, genetic and clinical limitations for the use of VKA. Patients will be followed for 6 months. Sample size: 130 patients will be recruited for 90% power based on the most conservative scenarios. Multivariate, cost-effectiveness analyses will be used.
Ethics and dissemination: The study design was approved by the ethical committee of Aragon. The trial is registered at Clinical Trials.gov dated 25/05/2017: NCT03154489. Trial results will be published in peer-reviewed journals and at conferences.
Postpartum uterine health, energy metabolism, and fertility of primiparous and multiparous crossbred dairy cows raised in the Amazon biome
Authors: Pfeifer Luiz , Andrade Jessica , Barbosa Ingrid , Gomes Leonardo , Silva Samira , Noleto Gabrielly , Silva Renata , Haridassa Felipe 
Published: May 2023

Abstract
This study aimed to compare the biological activity of the uterus and the metabolism between primiparous and multiparous crossbred dairy cows. Eighteen crossbred dairy cows (B. indicus x B. taurus) were divided by parity order into primiparous (n = 8), and multiparous (n = 10) cows. These cows were evaluated from parturition to 50 days in milk (DIM) for milk production, body weight, body condition score, subcutaneous fat thickness, seric β-hydroxybutyrate, and presence of purulent vaginal discharge. Also, uterine tissue was collected using the cytobrush technique to assess the proportion of polymorphonuclear cells and the abundance of IL-1B, IL-6, IL-8, TNFα, PGR, ESR1, ESR2, and PTCH2 transcripts. By 50 DIM, the cows were included in a timed artificial insemination (TAI) protocol. Multiparous cows tended to have greater milk production (P < 0.08). Primiparous cows had a higher (P ≤ 0.05) relative abundance of IL6, PTCH2, and PGR mRNA. In contrast, Multiparous cows had a higher relative abundance of IL10 mRNA. All cows ovulated after the TAI protocol. The proportion of primiparous cows ovulating from calving to 50 DIM tended (P = 0.08) to be greater. Overall, the findings indicated that parity does not significantly affect energy metabolism and that multiparous cows have lower uterine inflammatory response associated with lower relative expression of IL6 and higher relative expression of IL10. These results led us to conclude that parity had little effect on puerperium, and according to the postpartum uterine condition, crossbred dairy cows can be considered healthy by 40 DIM.
Integrated Biomarker Responses: A Further Improvement of IBR and IBRv2 Indexes to Preserve Data Variability in Statistical Analyses.
Authors: Mattos Jaco Joaquim , Siebert Marília Nardelli , Bainy Afonso Celso Dias 
Published: May 2023

Abstract
In biomonitoring and laboratory studies, it is typical to measure a battery of molecular, biochemical and cytogenetic biomarkers to evaluate the effects of xenobiotics in biota. However, summarizing the results of several biomarkers to inform laypersons and environmental agencies is still a challenge for researchers and environmental specialists. To address this issue, researchers have developed indexes such as the Integrated Biomarker Responses (IBR) and Integrated Biomarker Response version 2 (IBRv2) to summarize all biomarkers responses into a single value. Unfortunately, these indexes do not preserve the original biological variability, which hampers subsequent statistical analyses. In this study, we created improved versions of IBR and IBRv2, which preserve individual data variability and can be used in typical statistical analyses. The new Integrated Biomarker Responses individual (IBRi), Integrated Biomarker Responses version 2 individual (IBRv2i) and Weighted Integrated Biomarker Responses version 2 individual (Weighted IBRv2i) indexes correlated with the original IBR and IBRv2 indexes and were able to detect differences among experimental groups in a simulated and case studies. Using the IBRi, IBRv2i, or Weighted IBRv2i indexes is advantageous because they maintain the data variability of the experimental groups and can be analyzed using hypothesis testing statistics like any other parameter. Additionally, this approach can help translate technical scientific terminology into a more accessible language suitable for environmental governmental agencies and decision-makers.
Strong and Tough Conductive Hydrogel with High Sensitivity via Self-Assembly-Induced Bridge Crosslinking
Authors: Li Tian , Qi Haobo , Zhao Yijing , Kumar Punit , Dong Xinyu , Guo Xiao , Zhao Miao , Li Xinwei , Ritchie Robert O. , Zhai Wei 
Published: May 2023

Abstract
Conductive hydrogels possess a remarkable potential for applications in soft electronics and robotics, owing to their unique combination of high electrical conductivity, stretchability, and impressive self-healing capabilities. However, the limited strength and toughness of these hydrogels have traditionally impeded their practical implementation. Inspired by the hierarchical architecture of high-performance biological composites found in Nature, in this study we successfully fabricate a novel type of strong and tough conductive hydrogel through self-assembly-induced bridge crosslinking of MgB2 nanosheets and polyvinyl alcohol (PVA) hydrogels. By combining the micro- to nano-level hierarchical lamellar structures of the PVA hydrogels with the robust molecular-level B-O covalent bonds, the resulting conductive hydrogel exhibits an exceptional strength of 8.58 to 32.7 MPa and a high toughness of 27.56 to 123.3 MJ/m3. Moreover, the hydrogel demonstrates exceptional sensitivity (with a response/relaxation time of 20 ms and a detection lower limit of ~1Pa) under external deformation, due to its nanoscale MgB2 nanosheets/PVA lamellar structure and extremely low compressive modulus. These unique characteristics enable the conductive hydrogel to exhibit superior performance in advanced soft sensing applications, particularly in non-contact speaking detection. This study represents a major breakthrough, introducing a new class of conductive hydrogel that integrates exceptional strength, toughness, and sensitivity, thereby opening up exciting possibilities for the development of high-performance conductive hydrogels.
Cryo-EM structures of the cytochrome bc1 complex with metyltetraprole reveals the distinct mechanism of drug resistance
Authors: Yang Guang-Fu , Wang Yu-Xia , Ye Ying , Dong Jiangqing , Jiang Jia-Jia , Dong Ying , Wu Qiong-You , Zhu Xiao-Lei 
Published: May 2023

Abstract
Cytochrome bc1 complex (complex Ⅲ) is one of the most important targets for drug and fungicide discovery. Metyltetraprole (MET) is a novel inhibitor of complex Ⅲ, which has activity against the major reported mutations G143A and F129L of quinone site inhibitor (QoI)-resistant isolates. However, the anti-resistance mechanism of MET is still elusive and very intriguing to be explored. Here, we determined the near-atomic resolution structures of isolated complex III (2.88 Å) and MET-bound complex III (3.26 Å) by cryo-electron microscopy (cryo-EM), showing that MET exhibited a different binding mode from azoxystrobin, a typical QoI. MET could bind to the G143A or F129L mutated complex as well as to the wild-type complex III, whereas the binding affinity of azoxystrobin to the G143A or F129L mutants decreased significantly compared to the wild-type. This work provided a structural basis for the design of the next generation of inhibitors to overcome the resistance.
Organic electronics circuitry for in situ real-time processing of electrophysiological signals
Authors: Lauro Michele Di , De Salvo Anna , Rondelli Federico , Tomassini Alice , Greco Pierpaolo , Stieglitz Thomas , Fadiga Luciano , Biscarini Fabio 
Published: May 2023

Abstract
The next generation of brain-machine interfaces are envisioned to couple signal transduction, filtering, and sorting on board with minimum power consumption and maximum bio-integrability. These functional needs shall be mandatorily met in order to design efficient closed-loop brain-machine interfaces aimed at treating and monitoring various disorders of the central and peripheral nervous system. Here, we highlight the pivotal role organic bioelectronics may have in the contextual development of all these three desiderata, by demonstrating a modular organic-electronics circuit towards real-time signal filtering. The inherent filtering capabilities of electrolyte-gated organic transistor are tuned via adjustment of operational conditions and benchmarked in an electromyography experiment. Additionally, a whole-organic signal processing circuitry is presented, coupling such transistors with ad hoc designed organic passive components. This provides the possibility to sort complex signals into their constitutive frequency components in real time, thereby delineating innovative strategies to devise organic-based functional building-blocks for brain-machine interfaces.
Enacted Phronesis (Practical Wisdom) in Medical Practitioners: An Empirical Mixed Methods Study
Authors: Jameel S.Y , Jones J. 
Published: May 2023

AbstractBackgroundPhronesis (Practical Wisdom) is a useful way of conceptualising professional knowledge in the field of Medicine. Phronesis is one of five intellectual virtues described by Aristotle. Two of these intellectual virtues are well embedded in Medical Education; scientific knowledge (episteme) and technical skill (techne). The remaining two intellectual virtues are philosophical wisdom (sophia) and intellectual insight (nous). A critical interpretive literature review identified a lack of empirical work on the characteristics of phronemoi (wisdom exemplars). This paper is based on mixed-method PhD research which sought to determine the constituents of enacted phronesis in a population of family medicine practitioners in the UK. The work is positioned in a constructivist paradigm.MethodsA validated wisdom questionnaire (Ardelt 3D wisdom scale) was administered to 211 General Practitioners (GPs) at five training events. Outlier scoring doctors were invited to participate in biographic narrative interviews. 18 doctors were interviewed, 16 of which met Ardelt’s criterion for high levels of wisdom. Individual transcripts were analysed using the Wengraf biographic narrative interpretive method (BNIM), this looked at the lived life and told story of the exemplar and resulted in the generation of vignette statements which have been used for teaching. All transcripts were analysed using corpus linguistic frequency analysis, this enabled a conceptual framework to be produced which facilitated comparison of narratives and reflected the expressed thought-processes of the exemplars.Results34 constituents of enacted phronesis were identified in 5 key areas: their personal qualities, contexts, mental habits, knowledge-of-self and relational aspects. The 34 constituents inform practical action through wise deliberation. Comfort in dealing with uncertainty differentiated the wisdom exemplars from lower scoring participants.ConclusionsThis work has made explicit what is ordinarily tacit in relation to the process of phronesis. It has the potential to impact undergraduate medical education, continuing professional development and educational policy. The work also relates the concept of phronesis to flourishing (eudaimonia), and demonstrates that wiser doctors are happier doctors.
Carbon price prediction based on multiple decomposition and XGBoost algorithm
Authors: Xu Ke , Xia Zhanguo , Cheng Miao , Tan Xiawei 
Published: May 2023

Abstract
Carbon trading is an effective way to limit global carbon dioxide emissions. The carbon pricing mechanisms play an essential role in the decision of the market participants and policymakers. This study proposes a carbon price prediction model, Multi-Decomposition-XGBOOST, which is based on Sample Entropy and a new multiple decomposition algorithm. The main steps of the proposed model are as follows: (1) decompose the price series into multiple intrinsic mode functions (IMFs) by using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN); (2) decompose the IMF with the highest Sample Entropy by Variational Mode Decomposition (VMD); (3) select and recombine some IMFs based on their Sample Entropy, and then decompose them again via CEEMDAN; (4) predict IMFs by XGBoost model. The model has demonstrated reliable predictive performance in the evaluation of carbon price prediction in the Beijing market with significant price fluctuations. The proposed model achieves improvements of 30.437%, 44.543%, and 42.895% in RMSE, MAE, and MAPE, when compared to the individual models. The conclusion indicates that the proposed model has better predictive performance in carbon prices with higher volatility.
CO2 emissions of constructing China’s power grid towards carbon-neutral target: Based on top-down and bottom-up integrated model
Authors: Liu Yan 
Published: May 2023

Abstract
China is faced with huge pressure for achieving carbon-neutral target. Power sector is the largest industrial emitter in China, and renewable energy development would contribute to the large-scale construction of power grid. This study, based on top-down and bottom-up integrated models, aims to investigate carbon emissions of power grid construction, through identifying the key driving factors and forecasting their embodied emissions under the carbon neutrality target. Our results showed that, the increase of GDP dominated the increase in embodied carbon emissions of power grid construction, while energy efficiency and energy structure improvement contributed to the decrease. Large scale renewable energy development promotes the power grid construction. In 2060, total embodied carbon emissions would increase to 1105.7 Mt under the carbon neutrality target. However, the cost and key carbon-neutral technologies should be re-considered to ensure the sustainable electricity supply.
Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4 – 19 years with drug-resistant epilepsy: a real-world study
Authors: Youn Song Ee , Kang Hoon-Chul , Lee Joon Soo , Kim Heung Dong , Kim Se Hee 
Published: May 2023

Abstract
This study determined a 24-month outcome of perampanel (PER) treatment in children and adolescents with drug-resistant epilepsy. The percentage of ≥50% responders was 47.3% at 12 months and 49.0% at 24 months. A 100% reduction in seizures for more than 12 months was observed in 36 patients (12.2%). Discontinuation occurred in 117 patients (39.8%). The most common reason for discontinuation was adverse events (34/117 patients, 11.6%). Baseline seizure frequency was higher in children aged <12 years than patients aged ≥12 years, however, the percentage of seizure reduction and ≥50% responders did not significantly differ between the two groups. The rate of early discontinuation was higher (p=<.001), and the duration of PER treatment was shorter in children aged <12 years (p=.001). The most common reason for discontinuation was significantly different. Most children aged < 12 years discontinued PER because of inadequate effectiveness, while the adverse event was the most common reason in patients aged ≥12 years (p=.045). Only the slow titration was significantly associated with ≥50% of the responder. PER is an effective anti-seizure drug that can be used safely on a long-term basis for pediatric patients aged 4 to <12 years and for patients aged ≥12 years.
Woody Species Population Structure and Regeneration Status in Hereje Natural Forest, Southwest Ethiopia
Authors: Mammo Siraj , Anamo Abera , Bohnett Eve 
Published: May 2023

Abstract
Finding potential management interventions to lessen the negative effects of deforestation and forest degradation requires understanding the population structure and regeneration status of woody species in Ethiopia’s Hereje Natural Forest. The local population relies on the forest for ecosystem services, which in turn, alters the plant diversity and age structure of the forest and the regeneration status for future generations is uncertain. Hence, this study was conducted with the objective of determining the Woody Species population structure and regeneration status of woody species in Hereje Natural Forest in Southwest Ethiopia Three parallel transect lines (every 100 m) were established along altitudinal gradients, and 45 plots of 20 m x 20 m were used to collect vegetation data. Living woody species were counted and measured using diameter at breast height (DBH) measurements for DBH>2.5cm in each plot. Each main plot had five 2mx2m (4m2) subplots, one in the center and four at the corners. The regeneration status of each subplot was assessed by the species of woody plants present (seedlings, saplings, and mature trees/shrubs).On the studied plots, a total of 44 plant species were identified and classified into 28 families and 41 genera. The most relatively dominant species in the Hereje forest were Syzygium guineense (24.47%), Ficus sur (20%), Combretum molle (18.58%), Croton macrostachyus (18.11%), and Terminalia schimperiana (9.29%). According to the results, the density of tree species in the forest decreases as DBH classes increase. The predominance of small DBH classes is a result of excessive cutting for certain size classes by the local community, indicating extensive changes in the woody plant diversity and age structure. Overall, the forest's regeneration status was fair. Urgent interventions and enforced regulations are required to halt the major cause of forest deterioration, namely human-induced activities such as cattle grazing, illegal timber harvesting, and firewood collection. For long-term forest stability and biodiversity conservation, additional in-depth ecological studies are recommended regarding potential management interventions, monitoring protocols, and other ecological factors that contribute to the sustainable use of the forest and its products.
Automatic measurement of the Cobb angle for adolescent idiopathic scoliosis using convolutional neural network
Authors: Maeda Yoshihiro , Nagura Takeo , Nakamura Masaya , Watanabe Kota 
Published: May 2023

Abstract
This study proposes a convolutional neural network method for automatic vertebrae detection and Cobb angle (CA) measurement on X-ray images for scoliosis. 1021 full-length X-ray images of the whole spine of patients with adolescent idiopathic scoliosis (AIS) were used for training and segmentation. The proposed AI algorithm's results were compared with those of the manual method by six doctors using the intraclass correlation coefficient (ICC). The ICCs recorded by six doctors and AI were excellent or good, with a value of 0.973 for the major curve in the standing position. The mean error between AI and doctors was not affected by the angle size, with AI tending to measure 1.7°–2.2° smaller than that measured by the doctors. The proposed method showed a high correlation with the doctors’ measurements, regardless of the CA size, doctors’ experience, and patient posture. The proposed method showed excellent reliability, indicating that it is a promising automated method for measuring CA in patients with AIS.
Feasibility Study of a Powder-Based Supplement Intervention for a future Synbiotic Trial in Breastfed Children from South Africa
Authors: Shivakoti Rupak , Laughton Barbara , Shafiq Mehr , Schoeman Elisma , Glashoff Richard H , Barnabas Shaun , Fry Samantha , Leu Cheng-Shiun , Wang Shuang , Bode Lars , Aldrovandi Grace , Kuhn Louise , Slogrove Amy L 
Published: May 2023

Abstract
Background Children who are HIV-exposed uninfected (HEU), i.e., born to mothers living with HIV despite not acquiring HIV infection themselves, have increased morbidity and mortality. Data suggests that the breastmilk profile, and more specifically human milk oligosaccharide (HMO) composition, differ by maternal HIV status and may partly help explain this increased risk. We are currently conducting an HMO-based synbiotic randomized trial in breastfed children HEU, the MIGH-T MO study (ClinicalTrials.gov Identifier: NCT05282485), to assess the impact on health outcomes of children HEU. Here, we report our experience from a study of the feasibility and acceptability of a powder-based intervention given to breastfeeding children, conducted prior to the initiation of MIGH-T MO.Methods 10 mothers living with HIV and their breastfeeding children HEU accessing care at Tygerberg Hospital, in Cape Town, South Africa were enrolled. A powder-based product, potato maltodextrin, was mixed with expressed breast milk and administered to the infants daily for 4 weeks. Data on feasibility, acceptability, adherence, and health outcomes were assessed at the enrollment visit and at the 4 week visit, along with weekly telephone calls.Results 10 mother-infant pairs were enrolled in this study, with infant age ranging from 6–20 months of age. Among the mothers who met the eligibility criteria, all of them enrolled into the study suggesting high acceptability. While there was some loss-to-follow-up after the first visit, among the mothers who remained, there were no major feasibility concerns related to study procedures, product administration, adherence, tolerance, and health outcome assessment.Conclusion Our pilot study demonstrated that a powder-based intervention for breastfeeding children HEU in South Africa is acceptable and feasible. This suggests potential feasibility and acceptability for other larger studies, including our ongoing MIGH-T MO study, that use similar powder-based interventions such as probiotics, prebiotics, or synbiotics, in breastfed infants from similar settings.