bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the diversified roles of Anoctamin Family in Pan-Cancer
Authors: Liu Yifan , Lu Bingnan , Jia Xuyang , Yao Yuntao , Qu Mingyu , Yang Tianyue , Song Xu , Pan Xiuwu , Zhou Wang , Cui Xingang 
Published: August 2023

Abstract
Background
Anoctamin family (Transmembrane Protein 16), has gained growing attention for generating exosome and ectosome to mediate cancer cell communication in the process of phospholipid scrambling. However, former studies only focused on one narrow process in a single cancer. Instead, we designed a multidimensional study to comprehensively investigate the impact of ANO family on eight critical multi-omics cancer features in TCGA pan-cancer cohort.
Methods
TCGA pan-cancer cohorts were downloaded from UCSC xena. Differential analysis, survival analysis, and correlation analysis with tumor mutation burden, immune-phenotyping, stemness, cell proportion of tumor microenvironment, and drug sensitivity were conducted by R software. Alteration landscape was obtained from cBioportal with STRING database showing the protein-protein interaction network. Nanoparticle Tracking Analysis and Western Blot were employed to identify the ANO5 exosome.
Results
Extensive and profound associations were found between ANO family and eight crucial cancer features, including clinical prognosis, metastasis, drug resistance, tumor mutation burden, stemness, and tumor microenvironment. ANO1 possessed a high mutation frequency and is a driver gene in multiple cancers. ANO5 can exist in exosome to mediate cell-cell communication.
Conclusions
ANO family broadly participates in the proliferation, metastasis, and drug resistance in a barrage of cancers by generating extracellular vesicles to mediate cell-cell communication and interacting with TMB, stemness, stromal and immune cell proportions in tumor microenvironment. ANO members can serve as reliable biomarkers for prognosis of cancer, as well as promising targets for trans-cancer treatment.
Effects of the time of administration and the concentration of exogenous prostaglandin F on ovulation in pacu
Authors: Sato Rafael Tomoda , Abreu Mariana Roza , Kuradomi Rafael Yutaka , Silva Laíza Maria Jesus , Batlouni Sergio Ricardo 
Published: August 2023

Abstract
In this study, we evaluated the effects of applying Ciosin® (containing 0.25 mg/ml cloprostenol, an analogue of prostaglandin F2α (PGF2α)) at the time, five or seven hours after hypophysation resolving dose (experiment 1). In the experiment 2, at the time of hypophysation resolving dose, females were induced with 1.0 to 7.0 mL Ciosin /kg. Reproductive parameters and plasma levels of 17α-20β-dihydroxy-4-pregnen-3-one (DHP) and PGF2α were evaluated at the time of spawning for both experiments. Neither the timing of Ciosin application closer to the spawning nor its higher concentrations resulted in increased reproductive parameters or elevated PGF2α and DHP plasma levels. The absence of PGF2α peak at the time of ovulation in both experiments can be attributed to the rapid increase and subsequent decrease in exogenous PGF2α levels shortly after application. Interestingly, multivariate analysis in experiment 2 revealed two main clusters: one characterized by spawning failure, poor-quality spawns and low DHP levels; and the other by showing successful spawning, high fecundity and elevated DHP levels. Since it is known that the DHP binding to the nuclear progestin receptor induces prostaglandin receptor expression, these facts may explain why better reproductive performances were associated with higher endogenous DHP levels, but not with changes in exogenous PGF2α application. Although positive correlations were observed between DHP levels and good reproductive performance, the reasons behind the substantial variation in DHP levels among females subjected to the same treatments remain unknow. An emerging focus is to elucidate the pattern of expression of PGF2α receptors and its relationship with DHP in Piaractus mesopoatamicus.
Taxi1500: A Multilingual Dataset for Text Classification in 1500 Languages
Authors: Ma Chunlan , Imani Ayyoob , Ye Haotian , Pei Renhao , Asgari Ehsaneddin , Schütze Hinrich 
Published: August 2023

Abstract

While natural language processing tools have been developed extensively for some of the world's languages, a significant portion of the world's over 7000 languages are still neglected. One reason for this is that evaluation datasets do not yet cover a wide range of languages, including low-resource and endangered ones. We aim to address this issue by creating a text classification dataset encompassing a large number of languages, many of which currently have little to no annotated data available.We leverage parallel translations of the Bible to construct such a dataset by first developing applicable topics and employing a crowdsourcing tool to collect annotated data. By annotating the English side of the data and projecting the labels onto other languages through aligned verses, we generate text classification datasets for more than 1500 languages. We extensively benchmark several existing multilingual language models using our dataset. To facilitate the advancement of research in this area, we release 670 language in 1430 editions at the time of publishing. Our dataset and code are available at: https://github.com/cisnlp/Taxi1500.
The Impact of the Minimum Wage on Intra-Household Decision-Making: Evidence from Japan
Authors: Pan Qilu 
Published: August 2023

Abstract
In this study, I examine the impact of increasing the minimum wage on gender inequality within Japanese households. Employing a Difference-in-difference approach, I assess the effects on employment rates, hourly wages, and time allocation for both husbands and wives in Japan. Additionally, I estimate the disparity in hourly income between husbands and wives. The study analyzes the variation in time allocation as well. By utilizing data from the Japanese Household Panel Survey, the findings indicate that women, both with and without young children, respond positively to the increases in the minimum wage by increasing their employment rate, while husbands, in general, do not show significant responsiveness. However, both wives and husbands with young children exhibit a higher level of responsiveness to the minimum wage increase. Furthermore, raising the minimum wage helps reduce the gender wage gap within the household by encouraging wives to enter the labor force and work longer hours. Regarding time allocation, both wives with and without young children respond to the wage incentives, with those without young children reducing their investment in home production, and those with young children sacrificing leisure time. It is essential to note that the minimum wage hike primarily proves effective in reducing the gender wage gap within the labor market, rather than within the realm of home production.
JEL Classification: J12 , J16 , J22. J31
Event-triggered Synchronization of Discrete-time CVNNs with Mixed Delays: A Switching Approach
Authors: Duan Tengfei , Gong Weiqiang , Li Qiang 
Published: August 2023

Abstract
The event-triggered synchronization problem of discrete-time CVNNs characterized by mixed delays is investigated in this paper. Firstly, to enhance communication efficiency, we propose a switched event triggered mechanism (ETM) as an improvement over the conventional continuous-time ETM. In addition, our designed saturation controller exhibits switching property owing to the model’s switching feature. Subsequently, we develop a Lyapunov function suitable for analyzing the synchronization of the discrete neural network, and obtain sufficient conditions for model synchronization. Finally, the effectiveness of our proposed method is demonstrated through a numerical example.
Revealing the coupling relationship between the ecosystem service value and urbanization
Authors: Fan Yu , Ji Jiayang , Jia Changgeng , Luo Kunyu , Wei Chaoxiang 
Published: August 2023

Abstract
The rapid expansion of urban areas and intense human activities have exerted serious impacts on the structure and service functions of ecosystems. A clear understanding of the interaction between urbanization (UI) and ecosystem service (ES) is of great significance for formulating regulations of future urban development and environment protection. In this study, we analyzed the impacts of urbanization on ecosystem services from 2000 to 2020 in the Henan-Hubei-Hunan (HBN) urban in China. The results show that the urbanization process in the HNB evolves from a rapidly growing state to a steady state with a slower rise. The ESV in HBN increased from 2.75 trillion yuan in 2000 to 5.07 trillion yuan in 2020. There is an inverted U-shaped curve relationship between UI and ESV, the ESV sharply decrease when the urbanization index exceeded 0.5. Land urbanization and social urbanization has the greatest impact on ESV. There was an spatial heterogeneity in the hotspots of ecosystem services. The hot spots of ecosystem products services are distributed in the northeast of the study area, while regulation services and cultural services are distributed in the southwest of HBN. The results can provide insights for enhancing urban sustainability in the HBN region, as well other urban megaregion with similar characteristics throughout the world.
Comparative effect of environment on morphological, biochemical and phytochemical analysis of onion cultivated at high and low altitudes
Authors: Shukla Shardulya , Rawat Monisha , Kumar Nitish , Patel Manoj K. , Behera Rakesh K. , Thakur Mohan S. , Kumar Raj , Chaurasia Om P. , Saxena Shweta 
Published: August 2023

Abstract
Long harsh winter at the high-altitude reduces the cropping season to few months. So availability of fresh food is a major challenge at the high-altitude. Moreover vegetables imported from other regions (i.e., low-altitudes) may degrade in the nutritional quality, due to the long-transportation and logistic constrains. Keeping a view on the health-promoting qualities of onion (Allium cepa L.); the morphological, biochemical, and phytochemical profiling was studied in onion grown at high-altitude (3340 metres above mean sea level, Leh-Ladakh, India) with the lower-altitude (321 metres above mean sea level, Chandigarh, India). Higher-altitude cultivation resulted in better yield (32.55 ± 1.33 t/ha). Total soluble solid (10.62 ± 0.08 0B), crude protein (6.86 ± 0.10 g/100g), crude fat (0.17 ± 0.01 g/100g), total carbohydrate (93.78 ± 0.67 µg/g), nitrate (180.54 ± 7.77 mg/kg), sulphate (202.77 ± 2.95 mg/kg), nitrogen (1098.03 ± 15.26 mg/100g), sodium (97.05 ± 2.63 mg/100) and manganese (3.91 ± 0.05 mg/100g) contents were found higher at high-altitude whereas, phosphate (1058.27 ± 17.6 mg/kg), magnesium (150.68 ± 0.84 mg/100g), zinc (2.63 ± 0.04 mg/100g)), copper (2.32 ± 0.13 mg/100g)) and iron (16.56 ± 0.24 mg/100g) contents were found higher at low-altitude. Total phenolic (TPC) (5.93 ± 0.06 µg/mg), total flavonoid (TFC) (10.52 ± 0.13 µg/mg), quercetin (0.43 ± 0.01 µg/mg), anti-oxidant potential as indicated by ferric-reducing antioxidant power (FRAP) (42.27 ± 0.10 µg/mg) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) (43.22 ± 0.14%) content were higher in high-altitude grown onion bulbs. The high-altitude grown bulbs were found more effective in vegetative growth, yield and health promoting biochemical and phytochemical compound in comparison with low-altitude grown bulbs.
Optimisation of the Cutting Process on Machining Time of Ankle Foot as Transtibial Prosthesis Components Using Response Surface Methodology
Authors: Lestari Wahyu Dwi , Adyono Ndaru , Faizin Ahmad Khairul , Haqiyah Aridhotul , Sanjaya Kadek Heri , Nugroho Asep , Kusmasari Wyke 
Published: August 2023

Abstract
This study aims to investigate the optimal milling process parameters in minimizing the machining time of ankle foot as a component of the transtibial prostheses. The experimental design was carried out using the Boc Behnken technique with four factors and three levels for each factor and machining time as a response. The machining parameters evaluated in this study are spindle speed, feed rate, step over, and toolpath strategy. The physical experiments were conducted on three axes CNC milling machine using a flat endmill cutting tool. The experiment results were evaluated by variance analysis, graphical and numerical methods. Mathematical model of the optimal cutting combination parameters on machining time is determined by response surface method. Based on the results, it was found that the optimal cutting parameters in the ankle foot prosthesis manufacturing process on a CNC milling machine were spindle speed of 6500 rpm, feed rate of 800 m/min, step over of 0.2 mm, and toolpath strategy of the flowline. The optimal conditions were determined to obtain the machining time value of the ankle-foot prosthesis. The results of this study demonstrated that CNC milling provided the shortest time for machining of transtibial prosthesis components, which can guide the development of machining strategies for ankle-foot prostheses made from Al 6061 material.
Genetic polymorphism of Interlukine-6 in asymptomatic and ICU-admitted COVID-19 patients
Authors: Rashid Peshnyar M.A. , Salih Gaza F. 
Published: August 2023

AbstractBackground The global pandemic of Coronavirus Disease 2019 (COVID-19) has resulted in significant fatality rates. Clinical outcomes for affected individuals range from being asymptomatic to severe illness requiring intensive care unit (ICU) admission. Among the various factors contributing to the variation in clinical outcomes, host genetics play a prominent role. Interleukin-6 (IL6), a key player in immune responses, has been identified as having a crucial impact on viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Specifically, certain variations known as single nucleotide polymorphisms (SNPs) in the IL6 promoter region have been found to significantly influence IL6 expression and the severity of viral infections. Materials and Methods To explore the relationship between these genetic variations and COVID-19 in asymptomatic and ICU-admitted Kurdish patients, genetic sequencing was performed to determine the genotypes of nine IL6 SNPs. Results The study findings revealed that although the proportion of the GG genotype of rs1800795 was slightly higher in asymptomatic COVID-19 cases, the difference was not statistically significant (chi2 = 2.666, P = 0.236). Notably, Kurdish patients displayed a uniform genetic makeup (monomorphic) for the dominant alleles of rs2069830 (C), rs142759801 (C), rs2069857 (C), rs2069829 (G), rs2234683 (G), rs13447446 (T), rs527770772 (C), and rs13447445 (C). Furthermore, patients carrying the haplotype GCGGCTCCC were found to have a 0.481-fold higher likelihood of being asymptomatic with COVID-19 (P = 0.016, OR = 0.481). Conclusions this study demonstrates that the rs1800795 SNP is not statistically associated with COVID-19 at the genotype level. However, the presence of the dominant G allele of rs1800795 in the haplotype was found to be statistically associated with asymptomatic COVID-19 patients.
Regulatory mechanisms of runoff separation and sediment transport rates on sloping agricultural land via a combined planting method of Prunella vulgaris with earthworms in the soil
Authors: Wang Dongdong 
Published: August 2023

Abstract
The combination of prunella vulgaris and earthworm cultivation can effectively improve the economic benefits and utilization rate of small-scale sloping farmland, while also improving soil organically and preventing agricultural pollution and soil erosion. In this study, field-simulated rainfall experiments were conducted to investigate the regulatory mechanisms of runoff separation and sediment transport rates by planting Prunella vulgaris with earthworms. The runoff separation and sediment transport rates and bare slope significantly increased with a higher rainfall intensity or slope angle except for at a rainfall intensity of 1.2–1.6 mm/min and slope angle of 5°–10°. This relationship can be described using a binary linear or exponential equation with correlation coefficients > 0.6 or 0.9. Additionally, the regulatory effect of this study’s combined planting method on the runoff separation rate was positively correlated with rainfall intensity and negatively correlated with slope angle. A binary logarithmic function can describe this correlation, with rainfall intensity having a greater influence than the slope angle. Furthermore, the regulatory effect on the runoff separation rate was mainly due to the sediment transport rate, contributing 94.73% of the effect. The runoff separation rate primarily influenced the regulatory effect on the sediment transport rate, contributing to 70.81% of the effect.
Estimation of the Generalized Weibull distribution Parameters Based on Picard’s Method
Authors: Maswadah M. 
Published: August 2023

Abstract

In this study, numerical analysis has been used to estimate the lifetime distribution parameters based on the Picard iteration technique. The point estimates of the generalized Weibull model parameters were derived using Picard and Bayes methods based on the generalized progressive hybrid censoring scheme, via a Monte Carlo simulation. The Simulation results indicated that Picard’s method is highly efficient and outperforms Bayes’ method based on the informative and kernel priors using different loss functions. Finally, two real datasets, including COVID-19 data, were studied to ensure Picard’s method can be used more effectively than the most popular estimation methods in fitting and analyzing real-life data.
Women and Multi-tasking: Strategy or pitfall for Career Advancement?
Authors: Guramatunhu-Mudiwa Precious , Cherry Jewel B 
Published: August 2023

Despite the ubiquitous approach of multi-tasking in the workplace and home, research suggests that multi-tasking is not an effective strategy for productivity. Women multitask more than men do and are also perceived to be better multitaskers than men. The purpose of this paper is to share research on multi-tasking and its effects on productivity and to assist women in making informed decisions about whether multi-tasking is a strategy or a pitfall for career advancement. We discuss the perspectives on why women multi-task, the challenges associated with multi-tasking, and propose solutions. We conclude this paper by outlining successful strategies for career advancement in professional and personal spaces in a modern era where multi-tasking is the defacto coping strategy. Successful strategies include mindfulness, domestic sourcing, and the effective use of executive control functions such as goal switching and rule activation. We also discuss the importance of revisiting one's ethos, pathos, and logos
Recent Review on 1,3-Thiazole Derivatives as Therapeutic Targeted for Anticancer Activity
Authors: Mishra Shweta , Sahu Adarsh 
Published: August 2023

:
In the past two decades, targeted cancer therapy has emerged as a novel class of anticancer therapeutics besides traditional chemotherapy, surgery, and radiotherapy. There is an extensive variety of anticancer drugs in the market, and several compounds are in various stages of clinical trials. Many studies indicate that these cytotoxic molecules are also associated with various types of toxicity and contrary side effects; thus, researchers all over the world are working to develop more effective and safer anticancer drugs. 1,3-thiazole derivatives have recently been identified as a novel class of cancer chemotherapeutic agents with promising activity against various tumors. In this review, we have systematically summarized and highlighted the latest developments in 1,3-thiazole derivative for anticancer activity.
Soybean Collect Recommender Based on Distance and Productivity Cluster Using K-means Clustering and Simple Addictive Weighting Method
Authors: Ningtyas Mega Wahyu , Pribadi Feddy Setio 
Published: August 2023

Soybeans are an essential agricultural product that is one of the primary food sources in Indonesia, such as tempeh, tofu, soy milk, soy sauce, and other preparations. However, production yields, harvested land area, and soybean productivity in each district or city in Central Java Province vary widely. Differences in soybean productivity in each area are due to production factors such as area, use of fertilizers, seeds, and labor. This study tries to provide recommendations for soybean harvesting based on the distance and productivity of an area using K-means clustering and the simple addictive weighting method. In the Central Java Province, 35 regions will be divided into four clusters: the first with high productivity, the second with medium productivity; the third with low productivity; and the fourth with very low productivity. Additionally, based on the fourth cluster clustering results, it will be advised to take soybeans from other clusters by taking the closest distance and cluster members into account. According to the research, four clusters have formed: the first has five members, the second has fourteen, the third has nine, and the fourth has seven. The fourth cluster, which consists of seven members who do not grow soybeans, is advised to buy soybeans from the following regions: Kendal Regency, Klaten Regency, Magelang Regency, Batang Regency, and Brebes Regency.
Pengembangan LKS dengan Macromedia Flash Pembelajaran Eksplanasi Berbasis Ekologi SMPN 3 PU
Authors: Ardiansyah Vendra , Wardarita Ratu , Utami Puspa Indah 
Published: August 2023

Siswa sering kesulitan menulis teks eksplanasi karena bahan ajar yang kurang baik. Penelitian ini bertujuan untuk menghasilkan bahan ajar berbentuk LKS dengan menggunakan macromedia flash pada pembelajaran teks eksplanasi berbasis ekologi yang dapat digunakan oleh guru dan peserta didik di SMPN 3 Penukal Utara. Penelitian ini merupakan penelitian dan pengembangan (Research and Development) yang mengolaborasikan model pengembangan Jolly dan Bolitho dan model pengembangan Dick, Carey, dan Carey menjadi delapan langkah, yaitu: (1) identifikasi kebutuhan bahan ajar, (2) eksplorasi kebutuhan materi, (3) realisasi kontekstual, (4) realisasi pedagogik, (5) produksi bahan ajar, (6) validasi ahli, (7) merevisi pembelajaran, dan (8) merancang dan melakukan evaluasi formatif. Prototipe LKS hasil pengembangan terdiri dari: halaman mulai, petunjuk penggunaan, materi ajar, KI & KD, Tujuan, Peta Konsep, Materi. Untuk mengetahui validitas, kepraktisan, dan efek potensial LKS yang telah dikembangkan, dilakukan uji validasi oleh pakar/ahli dan tiga tahap evaluasi formatif menggunakan angket (kuesioner), wawancara, dan tes. Berdasarkan hasil validasi, LKS dikategorikan baik atau valid. Berdasarkan uji kepraktisan melalui evaluasi satu-satu dan uji coba kelompok kecil, LKS dikategorikan sangat baik atau sangat praktis. Dari hasil uji coba lapangan melalui pretes dan postes, terdapat peningkatan rata-rata nilai peserta didik sebesar 30,25 sehingga LKS dapat dikategorikan efektif bagi peserta didik.