bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-Aided design for the preparation of magnetic molecularly imprinted polymers for recognition of ethyl carbamate
Authors: Hu Xujia , Li Hongyuan , Cui Hongwei , Wu Yue 
Published: June 2023

Abstract
In this study, computer-aided design of molecularly imprinted systems was carried out using the quantum chemistry software Gaussian. Based on density functional theory (DFT), the interaction energies of the template-monomer complexes were calculated under the B3LYP, 6-31G+(d,p) basis set, and the reaction sites and Imprinting ratio were predicted based on the electrostatic potential map and NBO charge transfer. The urethane magnetic molecularly imprinted polymers (EC-MMIPs) were successfully prepared using surface molecular imprinting technique with Fe3O4 as the magnetic carrier. The polymers were characterized by scanning electron microscopy, Fourier transform infrared, X-ray diffraction, vibrating sample magnetometry and thermogravimetric analysis. The results of isothermal adsorption and dynamic adsorption experiments showed that the EC-MMIPs had good adsorption performance, reaching the maximum adsorption amount (18.53 µg/mg) within 40 min. In competitive adsorption experiments, the speckle coefficient was 2.3. In addition, EC-MMIPs showed good adsorption efficiency even after five uses.
ZIF-67 derived 2D porous carbon nanosheets decorated with Co nanoflakes as bifunctional electrocatalysts toward effective overall water splitting
Authors: Liu Ru , Zhang Haixia , Song Yanhui , Liu Peizhi , Xu Bingshe , Liang Jianguo , Guo Junjie 
Published: June 2023

Abstract
ZIF-67 derived Co-N-C catalysts exhibit efficient water splitting performance and thus have attracted intense research interest. However, the serious Co agglomeration and loss of most N atoms due to the high-temperature pyrolysis limit the further improvement of their electrocatalytic performance. Herein, we report a ZIF-67 derived 2D porous N-doped carbon nanosheets decorated with Co nanoflakes catalyst (Co@NC/CC-500) for OER and HER by a facile pyrolysis method at the low temperature of 500°C. Benefiting from the ultrahigh N doping (12 at%) and uniformly dispersed Co nanoflakes on 2D porous carbon nanosheets, which lead to a high content of Co-N active sites, the Co@NC/CC-500 catalyst performs outstandingly for HER and OER with overpotentials of 95 and 183 mV at 10 mA cm− 2, respectively. Furthermore, the alkaline water electrolyzer using Co@NC/CC-500 as the cathode and anode catalysts can achieve the current density of 10 mA cm− 2 at the cell voltage of 1.52 V. This special low-temperature production method may be extensively utilized to create precisely defined monometals or bimetals nanoflakes decorated on 2D porous N-doped carbon nanosheets for diverse electrochemical energy applications.
Bibliometric analysis of HIV Nursing Research between 1999 and 2022
Authors: Hao Jiaqi , Zhang Qian , Du Xiaoyu , Wang Fan , Liu Jing , Chen Jia 
Published: June 2023

Abstract

Background: Human immunodeficiency virus (HIV) nursing has become more prominent with the increase in chronic HIV infections. This study examined articles related to HIV nursing to determine how the profession has developed and its future direction.
Methods: HIV nursing-related articles published in the Web of Science core collection between 1999 and 2022 were searched. Microsoft Excel 2010 and VOSviewer were used to identify the contributions of countries, institutions, and authors in HIV related care. Collaborative maps, hot topics, and keywords trends were analyzed using VOSviewer and CiteSpace.
Results: A total of 1513 publications were extracted. A steady increase in articles published between 1999 and 2012 was observed. After 2012, the increase in the number of publications was relatively stable. However, since 2016, a downward trend in the number of publications has occured. The USA, South Africa, and the UK were the leading contributors to publications related to HIV nursing. The University of California (San Francisco, USA), the University of Cape Town (South Africa), and the University of KwaZulu-Natal (South Africa) were three key contributing institutions. William L. Holzemer was the author with the most important publications. AIDS Care was the top prolific journal. "HIV-related stigma", "Antiretroviral therapy and adherence", "mental health", and "social support" were the main topics in HIV nursing research.
Conclusion: Research in HIV nursing has gradually shifted from "HIV infection", "risk factors", and "transmission routes" to "social support", "depression", and "public health".
Robust Segmented Regression: Application to Oxygen Uptake Plateau Identification
Authors: Sarnaglia Alessandro J. Q. , Molinares Fabio A. Fajardo , Azevedo Paulo H. S. M. 
Published: June 2023

Abstract
Recently, segmented regression has been utilized as a “working” model for a bootstrap test to detect true oxygen uptake plateau. This approach employs an iterative procedure based on least squares to fit the model. However, it is widely acknowledged that least squares is highly sensitive to outliers, often yielding inefficient estimates. This paper proposes an alternative iterative method by substituting the least squares step with a M-estimator step. Leveraging the robust features of M-estimators, the proposed method is expected to exhibit resilience against outliers. To empirically investigate the performance of the proposed method, a Monte Carlo simulation study is conducted. For comparison purposes, the classical iterative method is also considered. The results indicate that, in uncontaminated scenarios, both methods exhibit similar behavior, with the classical method presenting a slightly superior performance. However, in contaminated cases, the classical method is highly deteriorated, with significant bias and root mean squared error, while the proposed method demonstrates much better performance. Both methods are employed to fit the “working” 3-segment regression model and perform a plateau test on apparently contaminated oxygen uptake data. The results reveal that, due to the presence of outliers, the classical method produces inflated estimates for the error variance and larger standard errors for all parameters, in comparison to the proposed method. Moreover, the plateau test conducted using the classical (robust) method leads to the rejection (confirmation) of a plateau of oxygen uptake for the same data. Overall, these findings highlight the superiority of the proposed method in handling outliers.
Data mining using artificial intelligence and molecular dynamics analysis to detect HIV-1 reverse transcriptase RNase H activity inhibitor
Authors: Ghafoor Naeem Abdul , Kırboğa Kevser Kübra , Baysal Ömür , Süzek Barış Ethem , Silme Ragıp Soner 
Published: June 2023

Abstract
In this study, we developed a process to identify an HIV-1 protein target and a new drug candidate. Genomic analysis was conducted on HIV-1 genomes to identify a viable target for disrupting viral replication and the reverse transcriptase enzyme. Based on MAUVE analysis, we selected the RNase H activity of the reverse transcriptase as the potential target due to its low mutation rate and high conservation. We screened 94,000 small molecule inhibitors and performed virtual screening. Molecular dynamics simulations and MM/PBSA were used to validate hit compounds' stability and binding free energy. Phomoarcherin B, known for its anticancer properties, emerged as the top candidate, showing potential as an inhibitor of HIV-1 reverse transcriptase RNase H activity.
Optical and spin-selective time-of-flight measurement of light-induced desorption of Rb from Fe3O4 surfaces
Authors: Asakawa Kanta , Tanabe Naoki , Kawauchi Taizo , Fukutani Katsuyuki , Hatakeyama Atsushi 
Published: June 2023

Abstract
Light-induced desorption of Rb atoms from a ferrimagnetic Fe3O4(001) surface was studied using a spin-selective optical　method. The results showed that the coverage dependence of the desorption intensity had a threshold at which the desorption　rate began to increase. The averaged magnetic quantum number of the desorbed atoms was small. These indicate that the light-induced desorption of Rb from an Fe3O4(001) surface occurs only in the high-coverage region and does not involve spin　transfer.
Elevated Aortic Stiffness After Pediatric Heart Transplantation
Authors: Coppola John-Anthony , Gupta Dipankar , Lopez-Colon Dalia , DeGroff Curt , Vyas Himesh V. 
Published: June 2023

Abstract
Background: In adults, arterial stiffness has been linked to the development of target end-organ damage, thought to be related to abnormal transmission of pulse pressure. Increased arterial stiffness and endothelial dysfunction have been hypothesized to contribute to the development of microvascular dysfunction and coronary allograft vasculopathy (CAV), an important comorbidity after heart transplantation. However, little data exists regarding arterial stiffness in pediatric heart transplantation and its influence on development of coronary allograft vasculopathy is not well understood. We sought to assess aortic stiffness and distensibility in pediatric post-heart transplant patients.
Methods A prospective, observational study analyzing the ascending (donor tissue) and descending aorta (recipient tissue) using transthoracic echocardiographic M-mode measurements in patients aged <21 years was conducted. Descending and ascending aorta M-modes were obtained from the subcostal long axis view, and the parasternal long axis view 3-5mm above the sinotubular junction, respectively. Two independent reviewers averaged measurements over 2-3 cardiac cycles, and Aortic Distensibility (AD) and Aortic Stiffness Index (ASI) were calculated using previously validated methods.
Results We recruited 39 heart transplant (HT) patients and 47 healthy controls. Median end diastolic dimension of the ascending aorta (donor tissue) was significantly larger in the transplant group than the control group (1.92cm vs. 1.74cm, p=0.01). Ascending aortic distensibility in post-transplant patients was significantly lower than in the control group (4.87 vs. 10.53, p<0.001). Ascending aortic stiffness index was higher in the transplant patients compared to the controls (4.63 vs. 2.21, p<0.001). Among transplant patients taking statins, the absolute measurements of the descending aorta at end systole (p=0.04) and end diastole (p=0.04) were larger compared to non-statin users.
Conclusion There is evidence of altered ascending aortic distensibility and stiffness parameters in post-heart transplant patients. Further studies are required to assess its influence on complications like development of coronary artery vasculopathy.
Genome architecture of an exceptionally invasive copepod crossing salinity boundaries
Authors: Du Zhenyong , Gelembiuk Gregory , Moss Wynne , Tritt Andrew , Lee Carol Eunmi 
Published: June 2023

Abstract

Background: Copepods are among the most abundant organisms on the planet and play critical functions in aquatic ecosystems. Among copepods, populations of the Eurytemora affinis species complex are numerically dominant in many coastal habitats and serve as the food source for major fisheries. Intriguingly, certain populations possess the unusual capacity to invade novel salinities on rapid time scales. Despite their ecological importance, high-quality genomic resources have been absent for calanoid copepods, limiting our ability to comprehensively dissect the genomic mechanisms underlying this highly invasive and adaptive capacity.
Results: Here, we present the first chromosome-level genome of a calanoid copepod, from the Atlantic clade (Eurytemora carolleeae) of the E. affinis species complex. This genome was assembled using high-coverage PacBio and Hi-C sequences of an inbred line, generated through 30 generations of full-sib mating. This genome consisting of 529.3 Mb (contig N50 = 4.2 Mb, scaffold N50 = 140.6 Mb) was anchored onto four chromosomes. Genome annotation predicted 20,262 protein-coding genes, of which ion transporter gene families were substantially expanded based on comparative analyses of 12 additional arthropod genomes. Also, we found genome-wide signatures of historical gene body methylation of the ion transporter genes and significant clustering of these genes on each chromosome.
Conclusions: This genome represents one of the most contiguous copepod genomes to date and among the highest quality of marine invertebrate genomes. As such, this genome provides an invaluable resource that could help yield fundamental insights into the ability of this copepod to adapt to rapid environmental transitions.
Classification of Type 2 Diabetes Mellitus Subtypes Defined by Traditional Chinese Medicine Based on High-order Brain Functional Network
Authors: Chen Yuna , Lyu Wenjiao , Lu Weiye , Zhao Kui , Tan Xin , Qin Chunhong , Huang Haoming , Qiu Wenbin , Wang Jiahe , Shao Cui , Qiu Shijun , Li Saimei 
Published: June 2023

Abstract
Type 2 diabetes mellitus (T2DM) cases have various complications in multiple organs, including the brain. According to traditional Chinese medicine (TCM), the clinical appearance of T2DM can be divided into two syndromes, namely a Deficiency Syndrome and an Excess Syndrome, depending on the patient’s clinical symptoms, pulse and tongue appearance. However, the differences between TCM of T2DM-related subtypes remain unclear. Compared to the conventional static functional connectivity (FC), dynamic FC constitutes a promising strategy for objective and non-invasive identification of possible imaging biomarkers of T2DM Deficiency and Excess Syndromes and may serve as effective diagnostic features for differentiating these two subtypes. This work aimed to utilize high-order FC to identify abnormal connectomics patterns in the Deficiency and Excess Syndromes of Type 2 Diabetes Mellitus using a multivariable, machine learning-based method. We first constructed large-scale high-order brain networks by analyzing the temporal synchronization of the dynamic FC time series among various pairs of cerebral regions. Subsequently, this information was employed to classify the T2DM Deficiency and Excess Syndromes using a support vector machine model. The built model had an 80% accuracy in distinguishing T2DM Deficiency Syndrome from T2DM Excess Syndrome, and detected aberrant high-order FC patterns between them. Furthermore, widespread connectivity alterations were identified, which reflected T2DM subtypes. Therefore, these findings provide valuable insights into the TCM understanding of T2DM.
A New Numerical Method for Solving Neuro-Cognitive Models via Chebyshev Deep Neural Network (CDNN)
Authors: Mohammadi Kimia Mohammadi , Babaei Maryam , Hajimohammadi Zeinab , Parand Kourosh 
Published: June 2023

Abstract
One of the fundamental applications of artificial neural networks is solving Partial Differential Equations (PDEs) which has been considered in this paper. We have created an effective method by combining the spectral methods and multi-layer perceptron to solve Generalized Fitzhugh–Nagumo (GFHN) equation. In this method, we have used Chebyshev polynomials as activation functions of the multi-layer perceptron. In order to solve PDEs, independent variables, which are collocation points, have been used as input dataset. Furthermore, the loss function has been constructed from the residual of the equation and its boundary condition. Minimizing the loss function has adjusted the appropriate values for the parameters of the network. Hence, the network has shown an outstanding performance not only on the training dataset but also on the Unseen data. Some numerical examples and a comparison between the results of our proposed method and other existing approaches have been provided to show the efficiency and accuracy of the proposed method. For this purpose different cases such as linear, nonlinear and multi dimensional equations are considered.
Promoter hypermethylation of neural-related genes relates to stemness in solid cancers
Authors: idris musa , Coussement Louis , Alves Maria M. , de Meyer Tim , Melotte Veerle 
Published: June 2023

Abstract
Background
DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a neural-related DNA hypermethylation fingerprint in colon cancer, where most of the top hypermethylated and downregulated genes have known functions in the nervous system. To evaluate the presence of this signature and its relevance to carcinogenesis in general, we considered 16 solid cancer types available in The Cancer Genome Atlas (TCGA).
Results
All tested cancers showed significant enrichment for neural-related genes amongst hypermethylated genes. This signature was already present in two premalignant tissue types, and could not be explained by potential confounders such as bivalency status or tumor purity. Further characterization of the neural-related DNA hypermethylation signature in colon cancer showed particular enrichment for genes that are overexpressed during neural differentiation. Lastly, an analysis of upstream regulators identified RE1-Silencing Transcription factor (REST) as a potential mediator of this DNA methylation signature.
Conclusion:
Our study confirms the presence of neural-related DNA hypermethylation fingerprint in various cancers, of genes linked to neural differentiation, and points to REST as a possible regulator of this mechanism. We propose that this fingerprint indicates an involvement of DNA hypermethylation in the preservation of neural stemness in cancer cells.
Tactile Hallucinations Alleviated by Pselaphesia Counterstimulation: A case report
Authors: Kalita Shweta , Mehdiratta Nikita , Birwatkar Drushti , Hirsch Alan 
Published: June 2023

Abstract
Objective: Treatment of haptic hallucinations using tactile counterstimulation.
Introduction: The specific management through applying tactile counterstimulation for haptic hallucination has not heretofore been presented.
Case presentation: This 23-year-old right-handed male with nine past hospitalizations for depression, alcohol abuse, and manic episodes presents with means of the perception that hands were touching him and sexually stimulating him. He would feel the specter’s hand or arm but not see the person. Usually, it was the same friendly woman. He would feel the touch around his chest, shoulders, or genitals. Her fingers would move in one place for 2-5 minutes, and occur 6-8 times a day. He would sometimes feel her elbows on his breasts, and the sensation would resolve when he put his hand on the region where the sensations were felt and would recur when he removed his hand. Mental Status Examination: Alert. Oriented x2. Cooperative, poor judgment and insight. Immediate Recall: able to recall six digits forwards and four digits backward. Interpretation of similarities concretely. Animal Fluency Test: 15 (abnormal). Columbia Suicide Severity Risk Scale: 25 (very severe suicide ideation).
Conclusions: Tactile counterstimulation may have acted as a distractor, causing a change of focus from the hallucinations to the actual physical stimulus. Alternatively, through stimulating large sensory fibers, potential sources of such tactile hallucinations, including the posterior cingulate cortex, may have been inhibited. In those who present with tactile hallucinations, a trial of counterstimulation tactile therapy may be worthwhile.
Study on arc shape, weldment microstructure and mechanical properties of Ti-6Al-4V welded by FFDP TIG waveform
Authors: Kuang Yingwei , Jia Jianjun , Zhu Zeguang , Gui Zixiao , Tian Jiyu , Wang Zhenmin 
Published: June 2023

Abstract
Ti-6Al-4V titanium alloy weldments were prepared by the conventional TIG and fast frequency double pulse TIG (FFDP TIG) waveforms. Arc shape, microstructure and mechanical properties of weldments were investigated. The arc core area of the FFDP TIG shrink gradually, the weldment fusion zone (FZ) width and heat affected zone (HAZ) width reduced by 18.2% and 31.3%. The molten pool intensive stirring effect and the heat input reduction by FFDP TIG waveform, resulting in the prior β grain size decreased by 55.6% and refinement of martensite αʹ structures. Microhardness, tensile strength of FFDP TIG weldment were higher than that of conventional TIG, the tensile strength and elongation reached 98.4% and 65.6% of the base metal, respectively. The results show that FFDP-TIG process improve the Ti-6Al-4V weldment microstructure and mechanical properties and can exhibit excellent performance in the practical applications.
The exposure of the world’s mountains to global change drivers
Authors: Dragonetti Chiara , Daskalova Gergana , Marco Moreno Di 
Published: June 2023

Abstract
Mountain areas around the world are exposed to different drivers of global change, facing a dichotomy between being both climatic refugia and highly sensitive ecosystems. Through two different metrics, the velocity and the magnitude of change, we quantified the exposure of the world’s mountains to three drivers of change: climate, land-use, and human population density. We estimated the acceleration of global change in mountain areas by comparing past (1975–2005) versus future (2020–2050) exposure to each driver. We found that Africa’s and Oceania’s mountains face the highest levels of future exposure to multiple drivers of change and will require strong adaptation strategies to preserve human activities and biodiversity. European mountains, in contrast, experience relatively limited exposure to global change, and could act as refugia. This knowledge can be used to prioritize proactive local-scale assessments and intervention to mitigate the risks faced by mountain biodiversity and mountain communities.
Suicidal Behaviors and Emotional Distress among University Students in Bangladesh: A Cross-sectional Study in Bangladesh
Authors: Muyeed Abdul , Mohsin Md. , Alam Md. Badsha , Mahmud Sultan , Hossain Md. Nowshad , Khatun Mst. Monira , Mamduda Nazratun Nayem 
Published: June 2023

Abstract
Background
The prevalence of suicidal behaviors among young people especially among university students is rising alarmingly worldwide. This study aimed to assess the suicidal risks and emotional distress among university students in Bangladesh.
Materials and Methods
The data were collected from different universities in Bangladesh from June 1, 2022, to June 30, 2022, using a convenience sampling technique. Depression, anxiety, and stress were measured using a 21-point depression, anxiety, and stress scale (DASS-21); insomnia was measured using the insomnia severity index (ISI), and the suicidal behaviors questionnaire revised (SBQ-R) was used to measure suicidal behaviors. Data were analyzed using STATA (version 16) software.
Results
Out of 620 students, 47.26% were females, and the mean age of the students was 22.66 (SD = 1.95) years. The prevalence of suicidal behaviors was found 20.2% among the students. In addition, the prevalence of depression, anxiety, stress, and insomnia were found 46.5%, 55.2%, 28.1%, and 20.7% respectively. It was found that the students who had depression, anxiety, stress, and insomnia symptoms had the prevalence of suicidal behaviors at 33.33%, 29.53%, 41.95%, and 42.19% respectively. Furthermore, the students who had depression, anxiety, stress, and insomnia were found to show 2.00 (1.11–3.62)**, 1.83 (0.99–3.38)*, 2.04 (1.15–3.65)**, and 1.97 (1.17–3.32)** times higher likelihood of suicidal behaviors compared to those without these symptoms.
Conclusion and Suggestions
The results of the study suggest that mental health-related disorders like depression, anxiety, stress, and insomnia are significantly associated with the likelihood of suicidal tendencies among university students in Bangladesh.