bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instant Effects of Semantic Information on Visual Perception
Authors: Enge Alexander , Süß Franziska , Rahman Rasha Abdel 
Published: April 2023

AbstractDoes our perception of an object change once we discover what function it serves? We showed human participants (n= 48, 31 female, 17 male) pictures of unfamiliar objects either together with keywords matching their function, leading to semantically informed perception, or together with non-matching keywords, resulting in uninformed perception. We measured event-related potentials (ERPs) to investigate at which stages in the visual processing hierarchy these two types of object perception differed from one another. We found that semantically informed as compared to uninformed perception was associated with larger amplitudes in the N170 component (150–200 ms), reduced amplitudes in the N400 component (400–700 ms), and a late decrease in alpha/beta band power. When the same objects were presented once more without any information, the N400 and event-related power effects persisted, and we also observed enlarged amplitudes in the P1 component (100–150 ms) in response to objects for which semantically informed perception had taken place. Consistent with previous work, this suggests that obtaining semantic information about previously unfamiliar objects alters aspects of their lower-level visual perception (P1 component), higher-level visual perception (N170 component), and semantic processing (N400 component, event-related power). Our study is the first to show that such effects occur instantly after semantic information has been provided for the first time, without requiring extensive learning.Significance StatementThere has been a long-standing debate about whether or not higher-level cognitive capacities such as semantic knowledge can influence lower-level perceptual processing in a top-down fashion. Here we could show for the first time that information about the function of previously unfamiliar objects immediately influences cortical processing within less than 200 ms. Of note, this influence does not require training or experience with the objects and related semantic information. Therefore, our study is the first to show effects of cognition on perception while ruling out the possibility that prior knowledge merely acts by pre-activating or altering stored visual representations. Instead, this knowledge seems to alter perception online, thus providing a compelling case against the impenetrability of perception by cognition.
Design principles of Cdr2 node patterns in fission yeast cells
Authors: Opalko Hannah , Geng Shuhan , Hall Aaron R. , Vavylonis Dimitrios , Moseley James B. 
Published: April 2023

AbstractPattern forming networks have diverse roles in cell biology. Rod-shaped fission yeast cells use pattern formation to control the localization of mitotic signaling proteins and the cytokinetic ring. During interphase, the kinase Cdr2 forms membrane-bound multiprotein complexes termed nodes, which are positioned in the cell middle due in part to the node inhibitor Pom1 enriched at cell tips. Node positioning is important for timely cell cycle progression and positioning of the cytokinetic ring. Here, we combined experimental and modeling approaches to investigate pattern formation by the Pom1-Cdr2 system. We found that Cdr2 nodes accumulate near the nucleus, and Cdr2 undergoes nucleocytoplasmic shuttling when cortical anchoring is reduced. We generated particle-based simulations based on tip inhibition, nuclear positioning, and cortical anchoring. We tested model predictions by investigating Pom1-Cdr2 localization patterns after perturbing each positioning mechanism, including in both anucleate and multinucleated cells. Experiments show that tip inhibition and cortical anchoring alone are sufficient for the assembly and positioning of nodes in the absence of the nucleus, but that the nucleus and Pom1 facilitate the formation of unexpected node patterns in multinucleated cells. These findings have implications for spatial control of cytokinesis by nodes and for spatial patterning in other biological systems.
Impaired AMPK activity contributes to the inflammatory phenotype and the reduced phagocytosis capacity of VASP-deficient macrophages
Authors: Laban Hebatullah , Frömel Timo , Fleming Ingrid , Benz Peter M. 
Published: April 2023

AbstractMacrophage polarization plays an important role in tissue regeneration. Numerous factors and signaling molecules affect polarization processes. Here we investigated the consequences of the genetic deletion of vasodilator-stimulated phosphoprotein (VASP), which increases macrophage M1 polarization through augmented signal transducer and activator of transcription 1 (STAT1) signaling, and AMP-activated protein kinase (AMPK), which attenuates inflammation by inhibiting STAT1 expression and signaling. While a basal activity of AMPK (phosphorylation on Thr172) was detected in macrophages from wild-type mice, AMPK phosphorylation was significantly reduced in VASP-deficient M1 macrophagesin vitroand the expression of the pro-inflammatory cytokines TNFα and IL-1β was increased in these cells. Consistent with the role of AMPK in macrophage phagocytosis, VASP-/-macrophage phagocytosis was also significantly impaired. Interestingly, impaired phagocytosis could be rescued by exogenous activation of AMPK. Mechanistically, we found that VASP binds directly to protein phosphatase 1 regulatory subunit 6 (PP1-R6) and we hypothesize that VASP-binding to PP1- R6/PP1 limits the PP1-dependent de-phosphorylation of AMPK in wild-type cells. Conversely, AMPK dephosphorylation by the PP1-R6/PP1 complex is enhanced in the absence of VASP. In summary, we have identified a link between VASP and AMP-activated protein kinase (AMPK) activity, which may contribute to the pro-inflammatory phenotype of VASP-deficient macrophages.
An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering
Authors: Cui Gaofeng , Botuyan Maria Victoria , Drané Pascal , Hu Qi , Bragantini Benoît , Thompson James R. , Schuller David J. , Detappe Alexandre , Perfetti Michael T. , James Lindsey I. , Frye Stephen V. , Chowdhury Dipanjan , Mer Georges 
Published: April 2023

AbstractThe recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformational equilibrium between an open and a pre-existing lowly populated closed state of 53BP1 in which the H4K20me2 binding surface is buried at the interface between two interacting 53BP1 molecules. In cells, these antagonists inhibit the chromatin recruitment of wild type 53BP1, but do not affect 53BP1 variants unable to access the closed conformation despite preservation of the H4K20me2 binding site. Thus, this inhibition operates by shifting the conformational equilibrium toward the closed state. Our work therefore identifies an auto-associated form of 53BP1 — autoinhibited for chromatin binding — that can be stabilized by small molecule ligands encapsulated between two 53BP1 protomers. Such ligands are valuable research tools to study the function of 53BP1 and have the potential to facilitate the development of new drugs for cancer therapy.
Alternative mRNA splicing controls the functions of the histone H3K27 demethylase UTX/KDM6A
Authors: Fotouhi Omid , Nizamuddin Sheikh , Falk Stephanie , Schilling Oliver , Knüchel-Clarke Ruth , Biniossek Martin L. , Timmers H.Th. Marc 
Published: April 2023

AbstractBackgroundTheUTX/KDM6Ahistone H3K27 demethylase plays an important role in development and is frequently mutated in cancers such as urothelial cancer. Despite many studies on UTX proteins, variations in mRNA splicing have been overlooked.MethodsUsing Nanopore sequencing, we present a comprehensive analysis ofUTX/KDM6Asplicing events in human cell lines and in tissue samples from bladder cancer and normal epithelium.ResultsThe central region ofUTXmRNAs encoded by exons 12 to 17 undergoes extensive alternative splicing. Up to half of all stable mRNAs (8-48% in bladder tissues and 18-58% in cell lines) are represented by theUTXcanonical isoform lacking exon 14 encoding a nuclear localization sequence, hence localize to the nucleus, unlike cytonuclear localization of the canonical isoform. Chromatin association was also higher for exon 14-containing isoform compared to the canonical UTX. Using quantitative mass spectrometry, we found that all UTX isoforms integrated into the MLL3 and MLL4, PR-DUB and MiDAC complexes. Interestingly, one of the novel UTX isoforms, which lacks exons 14 and 16, fails to interact with PR-DUB and MiDAC complex members.ConclusionUTXmRNAs undergo extensive alternative splicing that controls the subcellular localization of UTX and its interactions with other chromatin regulatory complexes.Simple SummaryUTX/KDM6Ais a histone H3K27 demethylase and plays an important role in mammalian development and human diseases such as urothelial cancer. We identified a region encompassing exons 12-17 ofUTXthat undergoes extensive splicing events. As a result, a nuclear localization sequence located in exon14 is missing in a considerable part ofUTXtranscripts in different cell lines and tissues from normal bladder epithelium and bladder cancer. Mass spectrometry analysis showed a role for this region in binding to the epigenetic PR-DUB and MiDAC complexes. UTX was also more extensively bound to chromatin when the alternative splicing region presented. Our study showed that alternative splicing ofUTXtranscripts plays an important role in its functions.
On the question of entrepreneurial breakthrough or failure in Africa: a framework for analysis
Authors: Yeboah-Assiamah Emmanuel , Hossain Farhad , Mamman Aminu , Rees Christopher J. 
Published: April 2023

PurposeHaving the right intent, aspiration, ability and attitude to become an entrepreneur has become the mantra in the extant literature to be driver of entrepreneurship and small and medium enterprise (SME) growth. Why would zealous and ambitious individuals with all rightful attributes so required of entrepreneurs have to fizzle out few years after venturing into business or SMEs? Perhaps these same individuals may relocate to other jurisdictions and would establish successful firms even beyond their imaginations. Beyond the individual’s entrepreneurial attributes, there are other external countervailing forces which either “enable” or “impede” entrepreneurial drive and SME growth processes. Adopting the theory of planned behavior, this study conceptualizes a systems framework to analyze how SMEs either flourish or fail in developing countries.Design/methodology/approachThe study relies on secondary sources of data. It adopts a critical stage review of secondary data.FindingsThe study argues that the interplay of “internal factors” and “external factors” of prospective entrepreneurs provides a useful framework to explain the general SME outlook of an economy. The study postulates that many internally driven prospective SME entrants (with entrepreneurial attitudes, abilities and aspirations) mostly in the developing economies may have their dreams shattered because of obstructive external ecological elements which tend to frustrate new business entrants as well as existing ones.Originality/valueWith the aid of a framework, this study conceptualizes a comprehensive framework to analyze how SMEs either flourish or fail in developing countries.
Reality checked? Conceptualising the relationship between work experience, abroad experience and university students' work value preferences
Authors: de Boer Peter , Bordoloi Prantik 
Published: April 2023

PurposeThe purpose of this study is to explore the degree of variance in work value preferences espoused by university students based on whether the students are in possession of work experience and experience abroad. Vocational identity development (VID) was used as a theoretical lens to explore the extent to which being in possession of experience in these two areas shapes vocational identity.Design/methodology/approachA questionnaire (n = 1,188) was employed to measure the relative salience for 8 latent work values constructs and 25 individual-level work values. Respondents were classified into two groups based on work experience and abroad experience, and the differences in work value preferences between these groups were explored.FindingsThe authors' comparison of sample groups revealed that respondents without experience abroad attached significantly greater importance to specific work values (e.g. stability, extrinsic motivation and leisure) than those with sojourner experience. The relative salience of specific work values (e.g. altruistic and extrinsic motivation) was found to be significantly greater for respondents without work experience than those with such experience, however, not to the extent of abroad experience. VID as a theoretical framework was found to be valuable in conceptualising how work value preferences appear to be the outcome of a process of co-construction between an individual and his environment.Research limitations/implicationsThe reasons as to how and why changes in work value salience occur cannot be conclusively established due to the exploratory nature and conceptual design of the present study.Practical implicationsThe findings suggest work and abroad experience play a pivotal role in shaping respondents' work values and, more generally, the VID. This reinforces the need for cooperation between higher education and industry to provide experiential learning opportunities and career guidance to enhance graduate employability and contribute to long-term engagement of talent in tight labour markets.Originality/valueThe value of these findings is that the findings contribute to greater conceptual understanding of the relationship between work experience, abroad experience and work value preferences. This is particularly relevant to academic staff and curriculum developers at a tertiary level in preparing and guiding university students in their interactions with professional practice.
A 30-year bibliometric assessment and visualisation of emotion regulation research: applying network analysis and cluster analysis
Authors: Rahaman Samsur , Govil Punita , Khan Daud , Jevremov Tanja D. 
Published: April 2023

Purpose
The emotion regulation research has drawn considerable attention from academicians and scholars in the contemporary world. As a result, the publications that are specifically dedicated to emotion regulation research are rapidly escalating. Therefore, this study aims to conduct a bibliometric analysis of research articles that have been published in the field of “emotion regulation.” The study primarily examines the growth and development of scholarly publications, seminal studies, influential authors, productive journals, research production and collaboration among countries, emerging research themes, research hotspots and thematic evolution of emotion regulation research.

Design/methodology/approach
The Web of Science Core Collection database was used to gather the study’s data, which was then analysed using VOSviewer and Bibliometrix, Biblioshiney open-source package of the R language environment.

Findings
The study’s results reveal that the research on emotion regulation has grown significantly over the last three decades. Notably, Emotion and Frontiers in Psychology are the most dominant and productive journals in the field of emotion regulation research. The most prominent author in the area of emotion regulation is identified as James Gross, followed by Gratz, Wang and Tull. The USA is at the forefront of research on emotion regulation and has collaborated with most of the developed countries like Germany, England and Canada. The keyword analysis revealed that the most potential research areas in the field of emotion regulation are functional magnetic resonance imaging, amygdala, post-traumatic stress disorder, borderline personality disorder, alexithymia, emotion dysregulation, depression, anxiety, functional connectivity, neuroimaging, mindfulness, self-regulation, resilience and coping. The thematic evolution reflects that the research on emotion regulation has recently focused on issues including Covid-19, non-suicidal self-injury, psychological distress, intimate partner violence and mental health.

Originality/value
The results of this study highlighted the current knowledge gaps in emotion regulation research and suggested areas for further investigation. The present study could be useful for researchers, academicians, planners, publishers and universities engaged in emotion regulation research.
Identifying the enablers of HR digitalization and HR analytics using ISM and MICMAC analysis
Authors: Verma Sunakshi , Rana Neeti , Meher Jamini Ranjan 
Published: April 2023

Purpose
This study aims to identify the enablers of human resource (HR) digitalization and HR analytics. This paper also aims to build a relationship map using interpretive structural modeling.

Design/methodology/approach
A systematic literature review is used to identify the key enablers of HR digitalization and HR analytics. Ten expert opinions have been taken from the key officials of IT firms located in New Delhi North Central Region.

Findings
This study is focused on the enablers of HR analytics. It is found that change management (CM) in the organization is the key enabler of implementing HR digitalization and analytics in an organization. However, other elements like learning culture, training and development, E-learning management and HR transformation (HRT) play a vital role in implementing HR analytics. It is also found that implementing artificial intelligence for HR practices is the ultimate goal for every organization.

Research limitations/implications
Management teams in IT firms should focus on the continuous learning process in the organization. The CM should be expedited for digitalization and adoption of HR analytics. Managers must go through the ramification of HRT, which possesses diligence in HR analytics and artificial intelligence.

Originality/value
This study explicitly talks about the enablers of HR digitalization and HR analytics. It also explores the relationship between the enablers. This study also describes the driving and dependence power of all the enablers.
A humanoid robot teleoperation approach based on waist–arm coordination
Authors: Fan Xinyang , Shu Xin , Tu Baoxu , Liu Changyuan , Ni Fenglei , Jiang Zainan 
Published: April 2023

Purpose
In the current teleoperation system of humanoid robots, the control between arms and the control between the waist and arms are individual and lack coordinated motion. This paper aims to solve the above problem and proposes a teleoperation control approach for a humanoid robot based on waist–arm coordination (WAC).

Design/methodology/approach
The teleoperation approach based on WAC comprises dual-arm coordination (DAC) and WAC. The DAC method realizes the coordinated motion of both arms through one hand by establishing a mapping relationship between a single hand controller and the manipulated object; the WAC method realizes the coordinated motion of both arms and waist by calculating the inverse kinematic input of robotic arms based on the desired velocity of the waist and the end of both arms. An integrated teleoperation control framework provides interfaces for the above methods, and users can switch control modes online to adapt to different tasks.

Findings
After conducting experiments on the dual-arm humanoid robot through the teleoperation control framework, it was found that the DAC method can save 27.2% of the operation time and reduce 99.9% of the posture change of the manipulated object compared with the commonly used individual control. The WAC method can accomplish a task that cannot be done by individual control. The experiments proved the improvement of both methods in terms of operation efficiency, operation stability and operation capability compared with individual control.

Originality/value
The DAC method better maintains the constraints of both arms and the manipulated object. The WAC method better maintains the constraints of the manipulated object itself. Meanwhile, the teleoperation framework integrates the proposed methods and enriches the teleoperation modes and control means.
Business cycle transmission between France and United Kingdom
Authors: Dadej Mateusz 
Published: April 2023

PurposeThe literature mostly investigates the business cycle transmission of the United Kingdom (UK) and France as a part of a wider group (e.g. European Exchange Rate Mechanism or G7), despite their historical links and regional significance. Thus, herein paper aims to analyse the inter-dependence of these economies and how a shock from one of them affects the other for the data since 1978 to 2019.Design/methodology/approachIn this paper, first, preliminary statistics were calculated in order to describe the historical relationship between these countries. The econometric part estimates the vector auto-regression model (VAR) to assess the inter-dependence of the economies. VAR model allows further to inspect the impulse response functions that shows the shock dynamics from one country to another. In order to verify if a shock from one of the economies is important to another, the study uses granger causality test.FindingsThe study establishes a strong link between these countries. A business cycle is transmitted significantly between the economies of France and UK, with a single standard deviation shock from France resulting in a long term effect of 0.4% change in gross domestic product (GDP) of UK and 1% vice versa. Additionally changes in GDP of both of the countries significantly Granger-cause change to GDP of the corresponding economy.Originality/valueThis is the first empirical study investigating the business cycle transmission between France and UK and providing a quantitative assessment of their inter-dependence.