bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional medicine and its impact on patient outcomes in type 2 diabetes mellitus therapy
Authors: Faridah Imaniar Noor , Perwitasari Dyah Aryani , Maer Khoirunnisa , Octapermatasari Resti , Novitasari Laras 
Published: January 2023

The growing number of people with diabetes mellitus enhance the increasing number of antidiabetic medicine used and also the use of traditional medicine as a complementary medicine. The choice of treatment is depend on the patients’ perception and will have an effect on compliance and clinical outcome. This study aimed to determine the relationship between patients’ perception of consuming a combination of Traditional Medicine (TM) and Synthetic Medicine (SM) and their compliance with medication, as well as to examine its impact on the outcomes of type 2 DM treatment at three community health centers in Yogyakarta. This study is a cross-sectional study. Participants that met the inclusion criterias were 110 patients with type 2 diabetes mellitus who had been taking TM-SM combination at least one month at three community health centers in the City of Yogyakarta. The main outcome is the relationship between perception and compliance, as well as the outcome of therapy. Result showed that from 110 patients, only 40 (36.4%) had a good perception of the use of TM-SM combination, and 32 patients (29.1%) succeeded in adhering to the recommended administration of synthetic drugs. A total of 49 patients (44.5%) reported controlled blood sugar levels as the outcome of DM management. Patients' perception of drug combination was proven unrelated to patient compliance and treatment outcome (p> 0.05). For the conclusion, there is no relationship between patients’ perception of taking a combination medication with adherence and treatment outcomes.
Keywords: Compliance, Perception, Type 2 Diabetes Mellitus, Therapy Outcome
Tyrosinase Inhibitory and Antioxidant Activity of Paederia foetida L.
Authors: Fawwaz Muammar , Rifai Yusnita , Djabir Yulia Yusriani , Mukhriani  , Alam Gemini 
Published: January 2023

Paederia foetida L. is a tropical Asian plant containing bioactive compounds and often used as functional foods. The aim of this study was to determine the antioxidant capacity and inhibitory activity of P. foetida leaves extract on tyrosinase activity. In addition, the total phenolic content (TPC) and total flavonoid content (TFC) were determined. TPC and TFC was evaluated by the Folin-Ciocalteu and the aluminum chloride (AlCl3) colorimetric method, respectively. The antioxidant capacity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC) method. The antioxidant capacity was expressed as trolox equivalent antioxidant capacity (TEAC) dan ascorbic acid equivalent capacity (AAEC). The tyrosinase inhibitory activity was conducted by enzyme-linked immunosorbent assay (ELISA) using L-tyrosine as a substrate and measured at 490 nm by ELISA reader. TPC in the crude extract, fraction A, and fraction B was 173.18 ± 3.99, 553.95 ± 5.70 and 405.37 ± 33.90, respectively. TFC in the crude extract, fraction A, and fraction B was 12.79 ± 0,25, 143.16 ± 9.27, 143.50 ± 6.90, respectively. The best antioxidant capacity of the extract was shown in the DPPH method (15.71 ± 1.6 mg TEAC/g and 100.77 ± 8.5 mg AAEC/g). Meanwhile, fraction B showed the best antioxidant capacity by the FRAP (11.48 ± 1.5 TEAC/g and 8.39 ± 1.2 mg AAEC/g ) and CUPRAC (116.34 ± 1.9 mg TEAC/g and 66.11 ± 1.3 mg AAEC/g) methods. Tyrosinase inhibitory activity exhibited that the IC50 of fraction A and B was 13.67 μg/mL and 13.37 μg/mL, respectively.
Pengembangan Lembar Kerja Peserta Didik Interaktif Menggunakan Liveworksheet pada Materi Teks Eksplanasi
Authors: Aryani Dessy , W Imam Suwardi , Priyanto Priyanto 
Published: January 2023

Penelitian ini bertujuan untuk menjabarkan proses pengembangan LKPD interaktif menggunakan liveworksheet, kepraktisan LKPD interaktif, dan keefektifannya. Jenis penelitian berupa pengembangan atau Research and Development (R&D) dengan model 4-D yaitu pendefinisian (define), pengembangan (design), perancangan (develop), dan penyebaran (disseminate). Subjek dalam penelitian ini adalah siswa kelas VIII SMP Negeri 17 Kota Jambi. Dalam proses pengembangan diperoleh hasil akhir validasi media dan validasi materi dengan kategori valid. Pengembangan LKPD dapat dinyatakan efektif berdasarkan selisih nilai N-gain tes awal dan tes akhir pada kemampuan kognitif dan psikomotorik. Pada aspek kognitif diperoleh nilai N-gain sebesar 0,62 dan aspek psikomotorik diperoleh nilai N-gain sebesar 0,69. Keduanya termasuk dalam kategori sedang. Berdasarkan hal tersebut, LKPD interaktif liveworksheet yang dikembangkan dapat digunakan menjadi bahan ajar pada materi teks eksplanasi pada jenjang SMP.
Ikon, Indeks, dan Simbol pada Cerpen Sesat Pikir Para Binatang Karya Triyanto Triwikromo
Authors: Fadhilla Indah , Hidayatika Uliana , Hira Hanna Hanifa , Farihah Hanan , Nabilah Ainatun 
Published: January 2023

Abstrak
Pembahasan dalam penelitian ini adalah mengenai ikon, indeks, dan simbol dalam cerpen “Sesat Pikir Para Binatang” karya Triyanto Triwikromo. Tujuan penelitian ini adalah untuk mengetahui berbagai tanda dalam bentuk ikon, indeks, dan simbol di cerpen “Sesat Pikir Para Binatang” karya Triyanto Triwikromo dan mengungkapkan makna atau amanat yang dapat diambil dari bentuk simbol. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Tahapan yang peneliti lakukan adalah proses pengumpulan data, proses analisis data, dan penyajian hasil analisis data. Penelitian ini menemukan bahwa terdapat ikon, indeks, dan simbol dalam cerpen “Sesat Pikir Para Binatang“ karya Triyanto Triwikromo untuk menggambarkan kemiripan antara naluri manusia dan insting binatang seperti kebuasan, kelabilan, dan keangkuhan. Penggambaran kemiripan ini bertujuan untuk mengkritik tingkah laku atau perilaku buruk manusia.
Kata kunci: Ikon; Indeks; Simbol; Insting binatang; Naluri manusia

Abstract
The discussion in this study is about icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo. The purpose of this study was to find out the various signs in the form of icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo and reveal the meaning or mandate that can be taken from the form of symbols. This study uses a qualitative method with a descriptive approach. The stages that the researchers did were the data collection process, the data analysis process, and the presentation of the data analysis results. This study found that there are icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo to describe the similarities between human instincts and animal instincts such as savagery, instability, and arrogance. The depiction of this resemblance aims to criticize human behavior or bad behavior.
Keywords: Icons; Index; Symbol; Animal instinct; Human instinct
Ekranisasi Novel Senior Karya Eko Ivano Winata ke Film Senior Karya Indra Gunawan
Authors: Esadiani Akmalia , Fitri Alya , Rahmani Mahabbati Izzati , Hidayatullah Syarif 
Published: January 2023

Abstrak
Ekranisasi dapat diartikan sebagai bentuk penyampaian pesan dari sebuah karya sastra menjadi bentuk yang lain. Tujuan penelitian ini yaitu untuk mengungkapkan proses ekranisasi yang terjadi dari novel Senior karya Eko Ivano Winata ke dalam film Senior karya Indra Gunawan. Metode yang digunakan penulis dalam mengkaji proses ekranisasi yaitu dengan metode deskriptif kualitatif. Teknik yang digunakan untuk memaparkan data yaitu dengan teknik membaca, mencatat, yang meliputi penambahan, pengurangan, dan perubahan bervariasi yang terjadi pada novel dan film Senior. Hasil penelitian dari proses ekranisasi yang telah dikaji memaparkan mengenai penambahan, pengurangan, dan perubahan bervariasi yang berkaitan dengan alur, latar, dan tokoh dari novel Senior karya Eko Ivano ke film Senior karya Indra Gunawan. Terdapat 6 penambahan alur, 6 pengurangan alur, dan 2 perubahan bervariasi alur. Lalu terdapat 2 penambahan latar, tidak terdapat penciutan latar dari novel ke film, dan 1 perubahan bervariasi latar. Lalu terdapat 1 penambahan tokoh, 3 penciutan tokoh, dan 1 perubahan bervariasi pada tokoh.
Kata Kunci : Ekranisasi, Novel, Film
Abstract
Ecranization can be interpreted as a form of conveying messages from a literary work into another form. The purpose of this study is to reveal the ecranization process that occurs from the novel Senior by Eko Ivano Winata into the film Senior by Indra Gunawan. The method used by the author in studying the ecranization process is a qualitative descriptive method. The technique used to present the data is by reading, taking notes, which include adding, subtracting, and various changes that occur in the novels and films of Senior. The research results from the ecranization process that has been studied describe the addition, subtraction, and various changes related to the plot, setting, and characters from the novel Senior by Eko Ivano to the film Senior by Indra Gunawan. There are 6 groove additions, 6 groove reductions, and 2 changes to varying grooves. Then there are 2 background additions, no background shrinkage from novel to film, and 1 change in various settings. Then there is 1 character addition, 3 character shrinkages, and 1 variable change in character.
Keywords: Ecranization, Novel, Film
Rare Case of Metaplastic Breast Carcinoma with Squamous Differentiation in Young Female: A Case Report
Authors: Agustina Rohana 
Published: January 2023

Background. Metaplastic breast carcinoma is a very rare breast cancer, only about 0.2"‘1% of all invasive breast carcinomas. The prognosis of these cancer is poor and aggressive, reported to have lower response rates to conventional adjuvant chemotherapy and a worse clinical outcome after chemotherapy than other forms triple"‘negative breast carcinomas. Histopathologically, metaplastic breast carcinoma has distinct patterns with different outcomes. Among the types of metaplastic carcinoma, squamous cell, high grade spindle cell and high grade adenosquamous carcinoma are associated with the worst prognosis. We report one case of metaplastic breast carcinoma with squamous differentiation in young patient.
Methods. We examined the breast tumor tissue of a female patient, evaluated the macroscopic and microscopic features and asked the patient about the clinical course of the disease. Inform consent was obtained from the patient for publication of this case report and accompanying images.
Results. We reported a young female patient with final diagnosis of pathology Mixed Infiltrating Duct Carcinoma of No Special Type Grade 3 and Metaplastic Breast Carcinoma with Squamous Differentiation (30%) that has invaded fat tissue with Ductal Carcinoma Insitu of High Nuclear Grade 3 with basis of the operation is still positive for the tumor mass. Patients lost follow"‘up and did not continue therapy.
Conclusion. Morphology of metaplastic breast carcinoma are important factors influencing patient outcome. Early diagnosis and wide local excision of the squamous"‘type metaplastic breast carcinoma mass can make a better prognosis.
Karakteristik Mutasi EGFR pada Pasien Kanker Paru Jenis Adenokarsinoma yang Diterapi dengan Tyrosien Kinase Inhibitor (TKI) di Rumah Sakit Paru Dr. H.A Rotinsulu Bandung
Authors: Puspita Desi , Dwi Astuti Vitri , Rina  , Sampurno Edi 
Published: January 2023

This descriptive study describes the proportion of Epidermal Growth Factor Receptor (EGFR) mutations in lung cancer Adenocarcinoma patients at Rumah Sakit Paru (RS Paru) Dr. H. A Rotinsulu Bandung in the range of 2018 to 2020.
EGFR mutations were examined using RGQ thera screen technology Real"‘Time Polymerase Chain Reaction from FFPE or cytology smear.
There are 44 data point mutations after examining the EGFR mutation. 59% cases were 40"‘60 years old group dan 52 % were female.
It was found that in this group 86% patient with single mutation and 16% had doube mutations. EGFR mutations occurred in Exon 21 L858R in 13 cases (30 %), Exon 21 L861Q in 1 case (2%), Exon 19del in 24 cases (55%), double mutation Exon 19 and Exon 20 T790M type in 2 cases (4%), double mutation Exon 19del and Exon 21 in 4 cases (9%).
Review: Phytochemical of Some Plants with Anticoagulant
Authors: Sitiawani Meisy , Azizah Zikra , Asra Ridho , Chandra Boy 
Published: January 2023

Background: Anticoagulants are drugs used to treat hypertension and cardiovascular disease.This review article aims to discuss several types of natural plants with anticoagulant activity.
Materials and Methods: The method used is the study of relevant literature(national and international journals) which is accessed through online sites such as Google Scholar, Research Gate, Science Direct, Springer Link, and NCBI, published in the last 10 years (2011-2021) with the keyword “herbal plant” or “medicinal plant” and “anticoagulant” and “cardiovascular”.
Results: Based on in vitro and in vivo tests, some plants such as Allium sativum L., Averrhoa bilimbi, Persea americana Mill., Tridax procumbens L., Carica papaya L., Rhizophora sp, Syzygiumcumini L., Piper batle L., Erigeron canadensis L., Ainsliaea fragrans, Averrhoa bilimbi, Carica papaya L., are types of plants with anticoagulant activity.
Conclusion: Herb can be used as alternative sources of new anticoagulant agents cause of their biological activity. The use of medicinal plants with therapeutic effects and minimal side effects can be the best choice for the prevention and treatment of various diseases including cardiovascular disorders.
Strategi program corporate social responsibility yang efektif pada masa pandemi covid-19 di sthala: a tribute portfolio hotel ubud, bali
Authors: Kartika I Made Bati 
Published: January 2023

Tujuan penelitian ini adalah untuk mengetahui strategi Corporate Social Responsibility yang efektif pada masa pandemi Covid-19 di Sthala a Tribute Portfolio Hotel Ubud, Bali. Penelitian ini dilakukan di Sthala, a Tribute Portfolio Hotel Ubud, Bali. Data yang digunakan berupa data kualitaif dan kuantitatif dari data primer dan sekunder yang dikumpulkan melalui observasi, wawancara, studi pustaka, dan dokumentasi. Informasi yang digunakan berasal dari informan kunci dan informan pangkal. Teknik analisis data yang digunakan adalah teknik analisis deskriptif kualitatif dan analisis SWOT. Hasil penelitian menunjukan bahwa program CSR Hotel Sthala Ubud Bali pada masa pandemi Covid-19 telah diimplementasikan dengan baik. Namun terdapat beberapa strategi yang dianggap lebih efektif untuk diimplementasikan dengan mempertimbangkan indikator SWOT serta faktor internal dan eksternal yang berengaruh pada masa pandemi Covid-19.Simpulan dari penelitian ini adalah Hotel Sthala Ubud Bali telah mengimplementasikan program CSR dengan baik dan terdapat strategi program CSR yang dianggap efektif untuk diimplementasikan pada masa pandemi Covid-19. Hotel Sthala Ubud Bali disarankan untuk mengimplementasikan strategi tersebut guna meningkatkan efektifitas program CSR di masa pandemi Covid-19.

The purpose of this research was to determine the effective Corporate Social Responsibility strategies during the Covid-19 pandemic at Sthala, a Tribute Portfolio Hotel Ubud, Bali.This research was conducted at Sthala, a Tribute Portfolio Hotel Ubud, Bali. The data used are qualitative and quantitative data from primary and secondary data collected through observation, interviews, literature study, and documentation. The information used comes from key informans and basic informant. The data analysis technique used is descriptive qualitative analysis technique and SWOT analysis. The results showed that the CSR program of Hotel Sthala Ubud Bali during the Covid-19 pandemic had been implemented well. However, there are several strategies that are considered more effective to be implemented by considering the SWOT indicators as well as internal and external factors that influence during the Covid-19 pandemic. Hotel Sthala Ubud Balii is advised to implement this strategy in order to increase the effectiveness of CSR programs during the Covid-19 pandemic.
Problems of Law Enforcement of Notary Code of Ethics in the Digital Era
Authors: Shodiq Achmad 
Published: January 2023

The purpose of this study is to analyze the problems faced by Notaries in implementing the code of ethics in the digital era and what are the problems of law enforcement of the notary code of ethics in the digital era. This research is normative juridical research using statutory, conceptual, and case approaches and analyzed descriptively qualitatively. The results of the analysis show that the digitalization era which is dominated by social media platforms can be an opportunity for Notaries to simplify their performance, but on the other hand it also opens up new potential for Notaries to take actions that violate the Notary's code of ethics. That is why the existence of the Notary Supervisory Council is very necessary to really carry out supervision and action against notaries who violate the code of ethics. The problem that has been experienced in the context of law enforcement of the notary code of ethics is that so far MPM seems to work half-heartedly, so that many Notaries do not heed the warnings or sanctions given when they are found to have violated the Notary Code of Ethics. Keywords: Digital Era, Ethics Code, Law Enforcement Problems, Notary.
“Strategi Media Relations dan Kaitannya dengan Citra Perusahaan” (Studi Kasus Proses Transformasi OT Grup)
Authors: Hadi Sigit Pramono , Dense Aldila 
Published: January 2023

ABSTRAKPerusahaan OT Grup telah eksis sejak tahun 1948 di Indonesia, kini tumbuh dengan memiliki 400 varian produk yang dikelola berdasar beberapa cluster produk yaitu makanan, minuman, perawatan, serta kebersihan dan sanitasi. Perusahaan mengusung spirit “Go Beyond” dimana perusahaan ingin dikenal selalu melihat selangkah lebih ke depan, tidak pernah menyerah dan selalu mengedepankan inovasi. Tujuan penelitian untuk mengetahui bagaimana strategi hubungan media OT Grup dan kaitannya dengan citra perusahaan. Metode penelitian adalah kualitatif deskriptif dengan teknik pengumpulan data indepth interview. Hasil penelitian menyatakan bahwa OT Grup menjalankan strategi media relations dengan fokus 3 kegiatan yaitu mengelola relasi, mengembangkan strategi dan mengembangkan jaringan. Dalam mengelola relasi, OT Grup membangun hubungan baik dengan pimpinan media dan wartawan. Dalam mengembangkan strategi, perusahaan memilih strategi earned media untuk memperoleh publisitas yang diperoleh dari pemberitaan dan percakapan di berbagai platform media terutama media digital. Dan dalam mengembangkan jaringan, perusahaan meningkatkan engagement di kalangan followers media sosial karena segmen yang disasar adalah kaum milenial. Meskipun konsumen sudah familiar dengan OT Grup, namun spirit inovasi yang diinginkan dalam OT “Go Beyond” belum tertangkap oleh konsumen. Hal ini menggambarkan bahwa strategi media relations yang dilakukan oleh OT Grup belum bisa dikaitkan seutuhnya dengan citra perusahaan. Kata kunci: corporate image; media relations; public relations; OT Grup
Data Mining Analytics Application for Estimating Used Car Price during the Covid-19 Pandemic in Indonesia
Authors: Putro Bramantiyo Eko , Indrawati Dwi 
Published: January 2023

Covid-19 has resulted in an increase in the people's need for vehicle ownership in order to avoid public transportation. People’s purchasing power, on the other hand, has also weakened. Therefore, they prefer to purchase affordable cars, such as used cars. Moreover, the Luxury Goods Sales Tax (PPnBM) discounts were officially applied to the purchase of the new cars in March 2021. This study aims at estimating the price of used cars using several data mining algorithms, such as Random Forest, K-Nearest Neighbour (KNN), and Naïve Bayes. By employing the RapidMiner tool, this study was able to evaluate the attributes affecting car prices. From the experimental results, random forest producers have the highest accuracy of 95.46%. Then, this study figured out that brand, engine capacity, kilometres, colours, years, number of passengers, and transmissions are the most influential attributes to determine the estimation of the used car prices.
Work Facility Design of the Ergonomic Tempeh Plastic Wraps Punching Tool Reduces Musculoskeletal Complaints and Working Time (A Case Study at MSME HM Tempe Murni, Ngoto, Yogyakarta)
Authors: Budiyanto Tri , Pambajeng Titan Restu 
Published: January 2023

Abstract. Tempe Murni small unit is a tempeh processing business located in Ngoto, Bangunharjo, Sewon, Bantul, Yogyakarta. There was a work process which caused muscle fatigue on the process of making holes on the tempeh wraps using manual tool because it had not met the ergonomic standard. The work posture of the workers in doing the work was sitting on the floor, the left leg was folded inward and the right leg was stretched forward a little bit, thus, it might cause musculoskeletal complaints. Therefore, it required an ergonomic tempeh plastic wrap punching tool which could reduce the musculoskeletal complaints and the working time of the workers.The research object was the workers in the process of making holes on the tempeh plastic wraps. This research used ergonomic and anthropometric approaches to determine the dimensions of the workers’ bodies. The Nordic Body Map (NBM) and the Visual Analogue Scale were used to determine the musculoskeletal complaints of workers.The results showed that the ergonomic design of the punching tool could reduce musculoskeletal complaints of pain sensation on the upper neck from the initial Visual Analog Scala (VAS) score of 65 into mild pain category with the scale score of 25. The initial back pain complaint with a moderate category with the scale score of 70 was reduced into mild pain category with the scale score of 16. The initial moderate pain on waist with the scale score of 70 was reduced into mild pain with the scale score of 18. The initial moderate pain on buttocks with the scale score of 70 was reduced into mild pain with the scale score of 26. The initial moderate pain on the lower part of the buttocks with a scale score of 69 was reduced into mild pain with a scale score of 29. The working time was reduced from 1.03 hours/unit into 0.52 hour/unit.
A Stochastic Integrated Inventory Model Single Supplier-Single Retailer in Periodic Review with Losing Flexibility Cost
Authors: Afrizal Rizqi , Linarti Utaminingsih 
Published: January 2023

Efficiency in the supply chain can be established by integrating the supplier-retailer inventory policy. This article proposes the integrated inventory model between supplier-retailer under stochastic demand. This model aims to determine the optimal review period and calculate the total inventory cost, including some defective items, backorder price discounts, and losing flexibility costs. We assume that the retailer can order 'n' times for every 'm' shipment from supplier to retailer in each production cycle under a periodic review. Stochastic conditions can cause sudden changes in orders by the retailer in large quantities, eventually forcing the supplier to reduce their setup policies. This condition makes the retailer be charged a losing flexibility cost as compensation for the reduction setup pushed by the supplier in a long-term partnership contract. Based on numerical examples and sensitivity analysis, the percentage of defective items in each shipment from supplier to retailer significantly affects integrated total inventory cost.