bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПІСЕННА КУЛЬТУРА УКРАЇНИ ЯК ДЖЕРЕЛО ДУХОВНОСТІ УКРАЇНСЬКОГО НАРОДУ
Authors: Сбітнєва Людмила 
Published: January 2023

У статті досліджується історія розвитку пісенної культури України як джерела духовності українського народу. Наголошено, що пісенна культура України має свої давні традиції. Вона була невід’ємною частиною самого життя і супроводжувала усі події в житті українського народу та впливала на формування моральних і естетичних уявлень українців.
Обґрунтовано, що українська народна пісня є одним із найкращих і найбагатших проявів духовних прикмет нашого народу. В її художніх образах історія народу відкривається ясно і велично. Зазначено, що важливу роль в народній пісні відіграє народно-поетичний пісенний матеріал, який володіє неповторною образною стихією та всебічно впливає на розвиток естетичних почуттів, розуміння художніх образів творів.
Доведено, що пісенна культура України має свої давні традиції, які було розпочато ще в Київській Русі, а особливе місце у розвитку співочої культури в Україні належить Києво-Печерській Лаврі. Перша «Співоча школа» була відкрита у містечку Глухові у 1738 році. В ній отримали музичну освіту велика кількість співаків і композиторів, які згодом стали відомими і своєю творчістю впливали на розвиток музичної культури українського народу.
Обґрунтовано, що ХVIII століття невипадково називають «золотою добою української музики», адже саме в цю пору розквітала музична творчість таких відомих композиторів як Д. Бортнянський, М. Березовський та А. Ведель.
Наголошено, що у другій половині ХІХ століття в українському культурному середовищі чимало українських композиторів виявляли інтерес до творчої обробки українських народних пісень.
Доведено, що у ХХ столітті, яке часто в мистецьких колах називають «пісенною епохою», українськими митцями було створено чимало пісенних творів з яскравими художніми образами, які стали популярними не тільки в нашій країні, але й далеко за її межами.
Автор вважає, що пісенне мистецтво, яке в українській музичній культурі займає особливе місце, протягом всієї історії українського народу відбивало національні ідеї, культуру мислення та сприяло зміцненню культурно-національної єдності. Пісенне мистецтво в Україні є глибоко національним та самобутнім явищем.
KONTRIBUSI PENEMPATAN TERHADAP MOTIVASI KERJA PEGAWAI DI DINAS PENDIDIKAN KOTA PADANG
Authors: Desfitri Eni 
Published: January 2023

This study aims to explain the contribution of placement to employee work motivation at the Padang City Education Office. The method used in this study is a quantitative research method of ex post facto research that will describe the contribution of placement to employee motivation at the Padang City Education Office. This population involved 51 samples from a total population of 121 people, with a stratified proportional random sampling technique with education level and years of service. Data collection techniques used questionnaires, and analyzed by statistical correlation and regression techniques. The results of data processing and analysis showed that the placement of employees contributed significantly (15%) to the work motivation of administrative employees. And it can be concluded that the placement of employees affects the work motivation of the Padang City Education Office employees. Keywords: Placement, Employees, Work Motivation
Scholarly Communication: A Discipline that should be promoted
Authors:   Pompeu Fabra University, Codina Lluís , Morales-Vargas Alejandro ,   University of Chile, Pedraza Jiménez Rafael ,   Pompeu Fabra University, Cortiñas-Rovira Sergi ,   Pompeu Fabra University
Published: January 2023

Scholarly	Communication	is	the	name	given	to	a	wide	field	of	activities	related	to	the	different	ways	in	which	the	authors	of	academic	works	publish	and	disseminate	their	results.	It	includes	tasks	whose	connections	to	this	publication	are	not	only	direct,	but	mutually	influenced.	These	are	the	tasks	of	dissemination,	treatment,	analysis,	and	information	retrieval,	such	as	those	carried	out	by	databases	and	other	agents.	But	the	issue	goes	even	further	and	other	activities	must	be	added,	equally	interconnected,	such	as	preservation	and	increased	visibility,	along	with	specialized	actions	carried	out	by	university	libraries.	It	is	concluded	that	academic	communication,	despite	its	breadth	and	diversity	(or	precisely	because	of	it),	should	be	studied	by	a	unified	discipline	that,	thanks	to	a	holistic	vision,	helps	to	overcome	its	main	problems.	This	paper	presents	some	of	these	problems	and	defends	the	need	for	both	the	field	of	activities	itself	and	the	discipline	that	studies	them	to	receive	a	clearer	and	more	determined	impulse.
Sandwich-type architecture film based on WS2 and ultrafast self-expanded and reduced graphene oxide in a Li-ion battery
Authors: Wenelska Karolina , Kędzierski Tomasz , Bęben Damian , Mijowska Ewa 
Published: January 2023

Since its discovery, graphene has been widely considered a great material that has advanced the Li-ion battery field and allowed development in its performance. However, most current graphene-related research is focused on graphene-based composites as electrode materials, highlighting the role of graphene in composite materials. Herein, we focused on a three-dimensional composite film with unique sandwich-type architecture based on ultrafast self-expanded and reduced graphene oxide (userGO) and exfoliated WS2. This strategy allows non-active agents [e.g., carbon black and poly (vinylidene fluoride)] free electrodes in LIBs in the form of a film. The ultra-quick exothermal nature of the USER reaction allows the rapid release of internally generated gases to create highly porous channels inside the film. Hence, the improved Li-ion transport in the LIBs boosted the electrochemical performance of both film components (ex-WS2 and reduced graphene), resulting in a high specific capacity of 762 mAh/g at .05 A/g and high Coulombic efficiency (101%) after 1,000 cycles. Overall, userGO showed the highest capacity at a low current, and ex-WS2 provided a higher reversible capacity. These results showed that the expanded graphene layer is an excellent shield for ex-WS2 to protect against pulverization, promoting both stability and capacity.
Contribution of soluble organic matter to hydrocarbon generation in saline lacustrine source rocks: Evidence from thermal simulation experiments
Authors: Xing Lantian , Xu Li 
Published: January 2023

Soluble organic matter generally exists in the source rocks of saline lacustrine basins. In this paper, we quantified the contribution of soluble organic matter to hydrocarbon generation based on thermal simulation experiments using a saline lacustrine source rock from the Qaidam Basin. Our results show that the yields of gaseous and liquid hydrocarbons in the thermal simulation products are greatly improved in the presence of soluble organic matter. As a comparison, the maximum yields of gaseous and liquid hydrocarbons in series C (without soluble organic matter) were 270 mg/gTOC and 329.78 mg/gTOC, respectively, while in series A (with soluble organic matter) they were 364 and 602.98 mg/gTOC, respectively. The proportion of isoprenoids and n-alkanes in the products also increased from approximately 3%–40%. Meanwhile, the presence of soluble organic matter reduced the temperature corresponding to the hydrocarbon generation peak from 375 to 250°C. Moreover, the presence of soluble organic matter also had a remarkable change on the stable carbon isotope composition of methane, resulting in more 12C enrichment with a range of 2.24‰–5.25‰. The combined evidence indicates that soluble organic matter can promote the formation of immature‒low maturity oil in source rocks.
Research on power trade potential and power balance between Lancang-Mekong countries and southern China under long-term operation simulation
Authors: Hao Zhang , Hai Lu , Enbo Luo , Yanting Huang , Zhi Wu , Chong Tang , Wenmeng Zhao , Guo Xie 
Published: January 2023

In order to further promote the interconnection development and construction of the power grids between the Lancang-Mekong countries and Southern China region and facilitate multilateral energy interaction, an assessment mechanism of the power balance and power trade potential between the two areas under long-term operation simulation is proposed. The mechanism first analyzes the energy supply structure, energy use forms, cross-border transmission capacity, and multi-area power trade potential of the power grids of the Lancang-Mekong countries and Southern China. Secondly, a power and electricity optimization model considering the long-period operation characteristics of generating units and regional interconnection transmission constraints is constructed, which can optimize the solution of a typical time-series operation scenario of 8760 h a year and improve the accuracy of regional power trade potential analysis. The results show that the Lancang-Mekong countries and the southern region of China have a significant potential for power trading, and the construction of a unified power trading market is vital for promoting the optimal allocation of power resources, achieving power balance, increasing the proportion of energy consumption, and reducing the cost of electricity consumption.
Interferon gamma-related gene signature based on anti-tumor immunity predicts glioma patient prognosis
Authors: Zhang Zhe , Shen Xiaoli , Tan Zilong , Mei Yuran , Lu Tianzhu , Ji Yulong , Cheng Sida , Xu Yu , Wang Zekun , Liu Xinxian , He Wei , Chen Zhen , Chen Shuhui , Lv Qiaoli 
Published: January 2023

Background: Glioma is the most common primary tumor of the central nervous system. The conventional glioma treatment strategies include surgical excision and chemo- and radiation-therapy. Interferon Gamma (IFN-γ) is a soluble dimer cytokine involved in immune escape of gliomas. In this study, we sought to identify IFN-γ-related genes to construct a glioma prognostic model to guide its clinical treatment.Methods: RNA sequences and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) and the China Glioma Genome Atlas (CGGA). Using univariate Cox analysis and the Least Absolute Shrinkage and Selection Operator (LASSO) regression algorithm, IFN-γ-related prognostic genes were selected to construct a risk scoring model, and analyze its correlation with the clinical features. A high-precision nomogram was drawn to predict prognosis, and its performance was evaluated using calibration curve. Finally, immune cell infiltration and immune checkpoint molecule expression were analyzed to explore the tumor microenvironment characteristics associated with the risk scoring model.Results: Four out of 198 IFN-γ-related genes were selected to construct a risk score model with good predictive performance. The expression of four IFN-γ-related genes in glioma tissues was significantly increased compared to normal brain tissue (p &lt; 0.001). Based on ROC analysis, the risk score model accurately predicted the overall survival rate of glioma patients at 1 year (AUC: The Cancer Genome Atlas 0.89, CGGA 0.59), 3 years (AUC: TCGA 0.89, CGGA 0.68), and 5 years (AUC: TCGA 0.88, CGGA 0.70). Kaplan-Meier analysis showed that the overall survival rate of the high-risk group was significantly lower than that of the low-risk group (p &lt; 0.0001). Moreover, high-risk scores were associated with wild-type IDH1, wild-type ATRX, and 1P/19Q non-co-deletion. The nomogram predicted the survival rate of glioma patients based on the risk score and multiple clinicopathological factors such as age, sex, pathological grade, and IDH Status, among others. Risk score and infiltrating immune cells including CD8 T-cell, resting CD4 memory T-cell, regulatory T-cell (Tregs), M2 macrophages, resting NK cells, activated mast cells, and neutrophils were positively correlated (p &lt; 0.05). In addition, risk scores closely associated with expression of immune checkpoint molecules such as PD-1, PD-L1, CTLA-4, LAG-3, TIM-3, TIGIT, CD48, CD226, and CD96.Conclusion: Our risk score model reveals that IFN-γ -associated genes are an independent prognostic factor for predicting overall survival in glioma, which is closely associated with immune cell infiltration and immune checkpoint molecule expression. This model will be helpful in predicting the effectiveness of immunotherapy and survival rate in patients with glioma.
Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated
Authors: Maaske Jill , Sproule Stephanie , Falsey Ann R. , Sobieszczyk Magdalena E. , Luetkemeyer Anne F. , Paulsen Grant C. , Riddler Sharon A. , Robb Merlin L. , Rolle Charlotte-Paige , Sha Beverly E. , Tong Tina , Ahani Bahar , Aksyuk Anastasia A. , Bansal Himanshu , Egan Timothy , Jepson Brett , Padilla Marcelino , Patel Nirmeshkumar , Shoemaker Kathryn , Stanley Ann Marie , Swanson Phillip A. , Wilkins Deidre , Villafana Tonya , Green Justin A. , Kelly Elizabeth J. 
Published: January 2023

BackgroundBreakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in coronavirus disease 2019 (COVID-19) vaccinees typically produces milder disease than infection in unvaccinated individuals.MethodsTo explore disease attenuation, we examined COVID-19 symptom burden and immuno-virologic responses to symptomatic SARS-CoV-2 infection in participants (AZD1222: n=177/17,617; placebo: n=203/8,528) from a 2:1 randomized, placebo-controlled, phase 3 study of two-dose primary series AZD1222 (ChAdOx1 nCoV-19) vaccination (NCT04516746).ResultsWe observed that AZD1222 vaccinees had an overall lower incidence and shorter duration of COVID-19 symptoms compared with placebo recipients, as well as lower SARS-CoV-2 viral loads and a shorter median duration of viral shedding in saliva. Vaccinees demonstrated a robust antibody recall response versus placebo recipients with low-to-moderate inverse correlations with virologic endpoints. Vaccinees also demonstrated an enriched polyfunctional spike-specific Th-1-biased CD4+ and CD8+ T-cell response that was associated with strong inverse correlations with virologic endpoints.ConclusionRobust immune responses following AZD1222 vaccination attenuate COVID-19 disease severity and restrict SARS-CoV-2 transmission potential by reducing viral loads and the duration of viral shedding in saliva. Collectively, these analyses underscore the essential role of vaccination in mitigating the COVID-19 pandemic.
Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection—The CoNAN long-term study
Authors: Schnizer Clara , Andreas Nico , Vivas Wolfgang , Kamradt Thomas , Baier Michael , Kiehntopf Michael , Glöckner Stefan , Scherag André , Löffler Bettina , Kolanos Steffi , Guerra Joel , Pletz Mathias W. , Weis Sebastian 
Published: January 2023

Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here, we assessed long-term immunity in individuals with mild COVID-19 up to 1 year after a localized SARS-CoV-2 outbreak. CoNAN was a longitudinal population-based cohort study performed 1.5 months, 6 months, and 12 months after a SARS-CoV-2 outbreak in a rural German community. We performed a time series of five different IgG immunoassays assessing SARS-CoV-2 antibody responses on serum samples from individuals that had been tested positive after a SARS-CoV-2 outbreak and in control individuals who had a negative PCR result. These analyses were complemented with the determination of spike-antigen specific TH cell responses in the same individuals. All infected participants were presented as asymptomatic or mild cases. Participants initially tested positive for SARS-CoV-2 infection either with PCR, antibody testing, or both had a rapid initial decline in the serum antibody levels in all serological tests but showed a persisting TH cell immunity as assessed by the detection of SARS-CoV-2 specificity of TH cells for up to 1 year after infection. Our data support the notion of a persistent T-cell immunity in mild and asymptomatic cases of SARS-CoV-2 up to 1 year after infection. We show that antibody titers decline over 1 year, but considering several test results, complete seroreversion is rare.Trial registrationGerman Clinical Trials Register DRKS00022416.
Comprehensive characteristics of pathological subtypes in testicular germ cell tumor: Gene expression, mutation and alternative splicing
Authors: Yao Xiangyang , Zhou Hui , Duan Chen , Wu Xiaoliang , Li Bo , Liu Haoran , Zhang Yangjun 
Published: January 2023

BackgroundTesticular germ cell tumor (TGCT) is the most common tumor in young men, but molecular signatures, especially the alternative splicing (AS) between its subtypes have not yet been explored.MethodsTo investigate the differences between TGCT subtypes, we comprehensively analyzed the data of gene expression, alternative splicing (AS), and somatic mutation in TGCT patients from the TCGA database. The gene ontology (GO) enrichment analyses were used to explore the function of differentially expressed genes and spliced genes respectively, and Spearman correlation analysis was performed to explore the correlation between differential genes and AS events. In addition, the possible patterns in which AS regulates gene expression were elaborated by the ensemble database transcript atlas. And, we identified important transcription factors that regulate gene expression and AS and functionally validated them in TGCT cell lines.ResultsWe found significant differences between expression and AS in embryonal carcinoma and seminoma, while mixed cell tumors were in between. GO enrichment analyses revealed that both differentially expressed and spliced genes were enriched in transcriptional regulatory pathways, and obvious correlation between expression and AS events was determined. By analyzing the transcript map and the sites where splicing occurs, we have demonstrated that AS regulates gene expression in a variety of ways. We further identified two pivot AS-related molecules (SOX2 and HDAC9) involved in AS regulation, which were validated in embryonal carcinoma and seminoma cell lines. Differences in somatic mutations between subtypes are also of concern, with our results suggesting that mutations in some genes (B3GNT8, CAPN7, FAT4, GRK1, TACC2, and TRAM1L1) occur only in embryonal carcinoma, while mutations in KIT, KARS, and NRAS are observed only in seminoma.ConclusionsIn conclusion, our analysis revealed the differences in gene expression, AS and somatic mutation among TGCT subtypes, providing a molecular basis for clinical diagnosis and precise therapy of TGCT patients.
A rapid method for detecting and distinguishing metallo-β-lactamase-and serine carbapenemase-producing Enterobacteriales using MALDI-TOF MS
Authors: Jing Xiaopeng , Hu Yanyan , Wu Tingting , Zhang Xing , Luo Shaofeng , Wang Wei , Min Xiaochun , Sun Ruiling , Zeng Ji 
Published: January 2023

IntroductionCarbapenemase-producing Enterobacteriales (CPE) are a major health threat worldwide, and therefore the development of rapid detection methods is needed. Here, we established a method to distinguish metallo-β-lactamase and serine carbapenemases using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with ethylenediaminetetraacetic acid (EDTA) and phenylboronic acid (PB).MethodsTo assess the specificity and sensitivity of the method, 110 carbapenemase-producing and 72 carbapenemase-negative Enterobacteriales isolates were collected, among which 51 strains produced only metallo-β-lactamase, 55 strains only serine carbapenemases, and four strains both metallo-β-lactamase and serine carbapenemases. In the proposed MALDI-TOF MS method, imipenem (IPM) and the bacterial strains to be tested were mixed, EDTA and/or PB was added, and the mixture was incubated for 4 h. The carbapenemase type was confirmed by the IPM waveform spectrum before and after incubation.ResultsBased on the presence, absence, and recovery of the IPM-cyano-4-hydroxy-cinnamic acid-specific waveform peak near 479 m/z, the detection sensitivity and specificity of the method were 98.2 and 100%, respectively.DiscussionAlthough CPE detection by MALDI-TOF MS has been studied previously, our method distinguishes between metallo-β-lactamase and serine carbapenemases, which will be very helpful for the clinical selection of antibiotics.
DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden
Authors: Huang Hao , Cao Weifan , Long Zhiping , Kuang Lei , Li Xi , Feng Yifei , Wu Yuying , Zhao Yang , Chen Yinggang , Sun Peng , Peng Panxin , Zhang Jinli , Yuan Lijun , Li Tianze , Hu Huifang , Li Gairui , Yang Longkun , Zhang Xing , Hu Fulan , Sun Xizhuo , Hu Dongsheng 
Published: January 2023

BackgroundImmune checkpoint inhibitor (ICI) therapy has proven to be a promising treatment for colorectal cancer (CRC). We aim to investigate the relationship between DNA methylation and tumor mutation burden (TMB) by integrating genomic and epigenetic profiles to precisely identify clinical benefit populations and to evaluate the effect of ICI therapy.MethodsA total of 536 CRC tissues from the Cancer Genome Atlas (TCGA) with mutation data were collected and subjected to calculate TMB. 80 CRC patients with high TMB and paired normal tissues were selected as training sets and developed the diagnostic and prognostic methylation models, respectively. In the validation set, the diagnostic model was validated in our in-house 47 CRC tissues and 122 CRC tissues from the Gene Expression Omnibus (GEO) datasets, respectively. And a total of 38 CRC tissues with high TMB from the COLONOMICS dataset verified the prognostic model.ResultsA positive correlation between differential methylation positions and TMB level was observed in TCGA CRC cohort (r=0.45). The diagnostic score that consisted of methylation levels of four genes (ADHFE1, DOK6, GPR75, and MAP3K14-AS1) showed high diagnostic performance in the discovery (AUC=1.000) and two independent validation (AUC=0.946, AUC=0.857) datasets. Additionally, these four genes showed significant positive correlations with NK cells. The prognostic score containing three genes (POU3F3, SYN2, and TMEM178A) had significantly poorer survival in the high-risk TMB samples than those in the low-risk TMB samples (P=0.016). CRC patients with low-risk scores combined with TMB levels represent a favorable survival.ConclusionsBy integrating analyses of methylation and mutation data, it is suggested that DNA methylation patterns combined with TMB serve as a novel potential biomarker for early screening in more high-TMB populations and for evaluating the prognostic effect of CRC patients with ICI therapy.