bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of stakeholder engagement practices in voluntary sustainability standards
Authors: van der Ven Hamish 
Published: September 2023

AbstractPractices of stakeholder engagement vary widely across voluntary sustainability standard setters. This study examines how the sponsorship structure of standard setters affects the diversity of stakeholders included in consultations and the influence of stakeholder input on standards. I compare six sustainability standard setters through an original dataset of 7945 stakeholder comments submitted during public comment periods between 2012 and 2019 to answer two research questions. First, are some standard setters better at balancing stakeholder representation than others? And second, does stakeholder influence vary across standard setters? I find that industry‐sponsored standards tend to attract more industry input than multistakeholder initiatives, but both tend to over‐represent legacy stakeholders. I also find that sponsorship is a poor predictor of which comments will be influential. Comments that seek to weaken or clarify the rules in voluntary sustainability standards are more likely to exert influence irrespective of the sponsorship of the standard setter.
The impact of agricultural minimum wages on worker flows in South Africa
Authors: Piek Marlies , von Fintel Dieter , Kirsten Johann 
Published: September 2023

AbstractThis paper is the first to provide estimates of how minimum wages affect worker flows and employment growth rates in an employment scarce developing country context. We investigate the effects of a large, exogenous increase in agricultural minimum wages in South Africa. We find that changes occurred primarily among non‐seasonal workers. Non‐seasonal agricultural employment growth decreased in the initial periods after the minimum wage hike. This was mainly driven by slower rates of entry. The effect on the rate of entry decreases over time. While farms also responded by shedding non‐seasonal workers at higher rates, this negative effect was limited to 1 year directly after the minimum wage hike. Employment growth recovers 4 years after the policy shock, indicating that firms adjusted relatively quickly despite the large legislated minimum wage increase. Seasonal employment growth and rates of entry and exit of seasonal workers were for the most part unaffected. Descriptive statistics, however, suggest a slight compositional change among seasonal workers: Farms replaced the worst paid seasonal workers with other low‐income workers who were slightly better paid and presumably more productive.
Moderating masculinity in women‐dominated digital spaces: Men and masculinity in the sims 4 online community
Authors: Palmer Zachary D. 
Published: September 2023

AbstractThis article examines gender dynamics within a women‐dominated online community centered around The Sims, a feminine‐coded simulation computer game in which women are the majority of players. Based on qualitative analysis of 10 threads and approximately 400 comments from both the official Sims 4 forums and unofficial Sims 4 subreddit, as well as online ethnography, I find that some men responded to their minority status within the Sims community by arguing that men were neglected by the developers at the expensive the inclusion of women and LGBTQ players, for instance, due to an imbalance of content designed for men versus women. However, these men experienced pushback against these ideas in such a way that minimized their voices. I argue that this pushback is a form of moderating masculinity to defend the safety of the community for women. This study contributes to our understanding of gender dynamics in digital spaces, particularly those dominated by women.
A spatiotemporal analysis of metro‐stop based accessibility to bus services in Shanghai, China
Authors: Shi Yuji , Yan Zhuofan 
Published: September 2023

AbstractGround‐level bus offers flexible services with relatively inexpensive fares and high‐level accessibility, thus is the dominant feeder mode for metro in the majority of metropolitan areas in China. Intermodal transfer between the metro and bus networks is therefore a crucial element in the successful operation of an integrated transit system. In this circumstance, a key challenge is lack of appropriate methodologies to evaluate the spatial–temporal disparities of intermodal transfers between metro and bus. To address this issue, this research aims to promote an existing two‐step floating catchment area (2SFCA) model by incorporating the temporal variability of service supply, demand, and travel time to provide a more realistic estimation of accessibility using smart card data and automatic vehicle location data. The proposed methodology was applied in a case study of the metropolitan area of Shanghai in the specific context of metro‐stop based accessibility to bus services. The results of the case study show that the daily fluctuations in output metro‐to‐bus transfer accessibility values are highly sensitive to temporal dynamics of transfer time, service supply, and demand. It is hoped the results output here could give planners and policymakers greater insight into spatiotemporal dynamics on transfer accessibility, and help to establish an effective and efficient integrated transit system.
Infectious complications of car T‐cell therapy: A longitudinal risk model
Authors: Czapka Michael T. , Riedell Peter A. , Pisano Jennifer C. 
Published: September 2023

AbstractBackgroundCAR T‐cell therapy, where a patient's own T cells are re‐engineered to express a receptor to a target of interest, is becoming an increasingly utilized cancer‐directed therapy. There are significant toxicities that contribute to a novel state of immunocompromise, leading to new patterns of infectious complications that require further detailed study.MethodsWe created a single‐center cohort of adult recipients of CD19‐directed CAR T‐cell therapy and assessed infectious outcomes, supportive care received, toxicities, and markers of immune function up to 2 years following CAR T‐cell therapy. Descriptive statistics were used as appropriate for analysis. We additionally conducted time‐to‐event analysis assessing time‐to‐first infection with either log‐rank testing or Cox regression with univariate analysis, before including significant predictors into a multivariate Cox model of time to infection.ResultsWe identified 73 patients who received CD19‐directed CAR T‐cell therapy who predominantly had diffuse large B‐cell lymphoma. Within 30 days of cell infusion, bacterial and Candida infections were the most common, with 64% of infections due to these organisms. Between 30 days and 2 years postinfusion, respiratory viruses and pneumonia were the most frequent infections, with 68% of infections due to these etiologies. Receipt of tocilizumab, development of immune effector cell‐associated neurotoxicity syndrome (ICANS), or lower neutrophil count were associated with quicker onset of infection in a multivariate Cox model.
imageConclusionsRespiratory viruses remain an important infectious complication of CAR T‐cell therapy following the first year. The model may be a useful tool to identify patients at the highest risk of infection.
Robust Design of Herringbone Grooved Journal Bearings Using Multi-Objective Optimization With Artificial Neural Networks
Authors: Massoudi Soheyl , Schiffmann Jürg 
Published: September 2023

Abstract
Herringbone grooved journal bearings (HGJBs) are widely used in micro-turbocompressor applications due to their high load-carrying capacity, low friction, and oil-free solution. However, the performance of these bearings is sensitive to manufacturing deviations, which can lead to significant variations in their performance and stability. In this study, design guidelines for robust design against manufacturing deviations of HGJB supported micro-turbocompressors are proposed. These guidelines are based on surrogate model-assisted multi-objective optimization using ensembles of artificial neural networks trained on a large dataset of rotor and bearing designs as well as operating conditions. The developed framework is then applied to a series of case studies representative of heat-pump and fuel-cell micro-turbomachines. To highlight the importance of rotor geometry and bearing aspect ratio in the robustness of HGJBs, two types of optimizations are performed: one focusing on optimizing the bearing geometry, and the other focusing on both the bearing and rotor geometries. The analysis of the Pareto fronts and Pareto optima of each type of optimization and case study allows for the derivation of design guidelines for the robust design of HGJB supported rotors. Results suggest that by following these guidelines, it is possible to significantly improve the robustness of herringbone grooved journal bearings against manufacturing deviations, resulting in stable operation. The best design achieved ±8 μm tolerance on the bearing clearance, and designs optimized for both rotor and bearing geometry outperformed those optimized for bearing geometry alone. This work successfully identifies guidelines for the robust design of herringbone grooved journal bearings in micro-turbocompressor applications, demonstrating the strength of surrogate model-assisted multi-objective optimization. It provides a valuable tool for engineers seeking to optimize the performance and reliability of these bearings.
How to Support Athlete Autonomy in University Sports: Coaches’ Experience of the reROOT Program
Authors: Lemelin Emilie , Kil Hali , Petit Élodie , Carpentier Joëlle , Forest Jacques , Gadoury Sophie , Richard Jean-Paul , Joussemet Mireille , Mageau Geneviève A. 
Published: September 2023

The purpose of this study was to evaluate coaches’ experience of the reROOT program, a program aiming to increase coaches’ autonomy-supportive skills, structure, and involvement. We delivered the program to 32 university sports coaches, and of these coaches, 13 participated in three semistructured focus groups 2 weeks postprogram and discussed their experience of the program. Guiding questions aimed at assessing participants’ responsiveness to the program and its perceived usefulness. Classical content analyses were performed and organized based on the guiding questions when applicable. Results suggest that coaches appreciated the program, believed that they could implement its skills in their day-to-day coaching, and observed positive impacts on themselves and their athletes despite the COVID-19 pandemic. It thus appears that coaches are responsive to the reROOT program and that it could be a useful part of their training.
Characterization of
Pseudomonas aeruginosa
resistance to ceftolozane-tazobactam due to
ampC
and/or
ampD
mutations observed during treatment using semi-mechanistic PKPD modeling
Authors: Deroche Luc , Aranzana-Climent Vincent , Rozenholc Albane , Prouvensier Laure , Darnaud Léa , Grégoire Nicolas , Marchand Sandrine , Ploy Marie-Cécile , François Bruno , Couet William , Barraud Olivier , Buyck Julien M. 
Published: September 2023

ABSTRACT

A double
ampC
(AmpC
G183D
) and
ampD
(AmpD
H157Y
) genes mutations have been identified by whole genome sequencing in a
Pseudomonas aeruginosa
(PaS) that became resistant (PaR) in a patient treated by ceftolozane/tazobactam (C/T). To precisely characterize the respective contributions of these mutations on the decreased susceptibility to C/T and on the parallel increased susceptibility to imipenem (IMI), mutants were generated by homologous recombination in PAO1 reference strain (PAO1- AmpC
G183D
, PAO1-AmpD
H157Y
, PAO1-AmpC
G183D
/AmpD
H157Y
) and in PaR (PaR-AmpC
PaS
/AmpD
PaS
). Sequential time-kill curve experiments were conducted on all strains and analyzed by semi-mechanistic PKPD modeling. A PKPD model with adaptation successfully described the data, allowing discrimination between initial and time-related (adaptive resistance) effects of mutations. With PAO1 and mutant-derived strains, initial EC
50
values increased by 1.4, 4.1, and 29-fold after AmpC
G183D
,
AmpD
H157Y
and AmpC
G183D
/AmpD
H157Y
mutations, respectively. EC
50
values were increased by 320, 12.4, and 55-fold at the end of the 2 nd experiment. EC
50
of PAO1-AmpC
G183D
/AmpD
H157Y
was higher than that of single mutants at any time of the experiments. Within the PaR clinical background, reversal of AmpC
G183D
, and AmpD
H157Y
mutations led to an important decrease of EC
50
value, from 80.5 mg/L to 6.77 mg/L for PaR and PaR-AmpC
PaS
/AmpD
PaS
, respectively. The effect of mutations on IMI susceptibility mainly showed that the AmpC
G183D
mutation prevented the emergence of adaptive resistance. The model successfully described the separate and combined effect of AmpC
G183D
and AmpD
H157Y
mutations against C/T and IMI, allowing discrimination and quantification of the initial and time-related effects of mutations. This method could be reproduced in clinical strains to decipher complex resistance mechanisms.
Recovery of 52 bacterial genomes from the fecal microbiome of the domestic cat (
Felis catus
) using Hi-C proximity ligation and shotgun metagenomics
Authors: Rojas Connie A. , Gardy Jennifer , Eisen Jonathan A. , Ganz Holly H. 
Published: September 2023

ABSTRACT

We used Hi-C proximity ligation with shotgun sequencing to retrieve metagenome-assembled genomes (MAGs) from the fecal microbiomes of two domestic cats (
Felis catus
). The genomes were assessed for completeness and contamination, classified taxonomically, and annotated for putative antimicrobial resistance (AMR) genes.
Identification and characterization of novel alphacoronaviruses in
Tadarida brasiliensis
(Chiroptera, Molossidae) from Argentina: insights into recombination as a mechanism favoring bat coronavirus cross-species transmission
Authors: Cerri Agustina , Bolatti Elisa M. , Zorec Tomaz M. , Montani Maria E. , Rimondi Agustina , Hosnjak Lea , Casal Pablo E. , Di Domenica Violeta , Barquez Ruben M. , Poljak Mario , Giri Adriana A. 
Published: September 2023

ABSTRACT

Bats are reservoirs of various coronaviruses that can jump between bat species or other mammalian hosts, including humans. This article explores coronavirus infection in three bat species (
Tadarida brasiliensis, Eumops bonariensis
, and
Molossus molossus
) of the family Molossidae from Argentina using whole viral metagenome analysis. Fecal samples of 47 bats from three semiurban or highly urbanized areas of the province of Santa Fe were investigated. After viral particle enrichment, total RNA was sequenced using the Illumina NextSeq 550 instrument; the reads were assembled into contigs and taxonomically and phylogenetically analyzed. Three novel complete Alphacoronavirus (AlphaCoV) genomes (Tb1–3) and two partial sequences were identified in
T. brasiliensis
(Tb4–5), and an additional four partial sequences were identified in
M. molossus
(Mm1–4). Phylogenomic analysis showed that the novel AlphaCoV clustered in two different lineages distinct from the 15 officially recognized AlphaCoV subgenera. Tb2 and Tb3 isolates appeared to be variants of the same virus, probably involved in a persistent infectious cycle within the
T. brasiliensis
colony. Using recombination analysis, we detected a statistically significant event in Spike gene, which was reinforced by phylogenetic tree incongruence analysis, involving novel Tb1 and AlphaCoVs identified in
Eptesicus fuscus
(family Vespertilionidae) from the U.S. The putative recombinant region is in the S1 subdomain of the Spike gene, encompassing the potential receptor-binding domain of AlphaCoVs. This study reports the first AlphaCoV genomes in molossids from the Americas and provides new insights into recombination as an important mode of evolution of coronaviruses involved in cross-species transmission.

IMPORTANCE

This study generated three novel complete AlphaCoV genomes (Tb1, Tb2, and Tb3 isolates) identified in individuals of
Tadarida brasiliensis
from Argentina, which showed two different evolutionary patterns and are the first to be reported in the family Molossidae in the Americas. The novel Tb1 isolate was found to be involved in a putative recombination event with alphacoronaviruses identified in bats of the genus
Eptesicus
from the U.S., whereas isolates Tb2 and Tb3 were found in different collection seasons and might be involved in persistent viral infections in the bat colony. These findings contribute to our knowledge of the global diversity of bat coronaviruses in poorly studied species and highlight the different evolutionary aspects of AlphaCoVs circulating in bat populations in Argentina.
Soft scattering evaporation of dark matter subhalos by inner galactic gases
Authors: Bi Xiao-jun , Gao Yu , Jin Mingjie , Lin Yugen , Xiang Qian-Fei 
Published: September 2023

AbstractThe large gap between a galactic dark matter subhalo’s velocity and its own gravitational binding velocity creates the situation that small subhalos can be evaporated before dark matter thermalize with baryons due to the low binding velocity. In case dark matter acquires an electromagnetic dipole moment, the survival of low-mass subhalos requires stringent limits on the photon-mediated soft scattering. The current stringent direct detection limits indicate for a small dipole moment, which lets DM decouple early and allows small subhalos to form. We calculate the DM kinetic decoupling temperature in the Early Universe and evaluate the smallest protohalo mass. In the late Universe, low-mass subhalos can be evaporated via soft collision by ionized gas and accelerated cosmic rays. We calculate the subhalos evaporation rate and show that subhalos lighter than $$10^{-5}M_{\odot }$$

10

-
5

M
⊙

in the gaseous inner galactic region are subject to evaporation via dark matter’s effective electric and magnetic dipole moments below current direct detection limits, which potentially affects the low-mass subhalos distribution in the galactic center.
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
Authors: Gleason Caroline E. , Dickson Mark A. , Klein (Dooley) Mary E. , Antonescu Cristina R. , Gularte-Mérida Rodrigo , Benitez Marimar , Delgado Juliana I. , Kataru Raghu P. , Tan Mark Wei Yi , Bradic Martina , Adamson Travis E. , Seier Kenneth , Richards Allison L. , Palafox Marta , Chan Eric , D'Angelo Sandra P. , Gounder Mrinal M. , Keohan Mary Louise , Kelly Ciara M. , Chi Ping , Movva Sujana , Landa Jonathan , Crago Aimee M. , Donoghue Mark T.A. , Qin Li-Xuan , Serra Violetta , Turkekul Mesruh , Barlas Afsar , Firester Daniel M. , Manova-Todorova Katia , Mehrara Babak J. , Kovatcheva Marta , Tan Nguan Soon , Singer Samuel , Tap William D. , Koff Andrew 
Published: September 2023

Abstract

Purpose:
We conducted research on CDK4/6 inhibitors (CDK4/6i) simultaneously in the preclinical and clinical spaces to gain a deeper understanding of how senescence influences tumor growth in humans.

Patients and Methods:
We coordinated a first-in-kind phase II clinical trial of the CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma (DDLS) with cellular studies interrogating the molecular basis of geroconversion.

Results:
Thirty patients with progressing DDLS enrolled and were treated with 200 mg of abemaciclib twice daily. The median progression-free survival was 33 weeks at the time of the data lock, with 23 of 30 progression-free at 12 weeks (76.7%, two-sided 95% CI, 57.7%–90.1%). No new safety signals were identified. Concurrent preclinical work in liposarcoma cell lines identified ANGPTL4 as a necessary late regulator of geroconversion, the pathway from reversible cell-cycle exit to a stably arrested inflammation-provoking senescent cell. Using this insight, we were able to identify patients in which abemaciclib induced tumor cell senescence. Senescence correlated with increased leukocyte infiltration, primarily CD4-positive cells, within a month of therapy. However, those individuals with both senescence and increased TILs were also more likely to acquire resistance later in therapy. These suggest that combining senolytics with abemaciclib in a subset of patients may improve the duration of response.

Conclusions:
Abemaciclib was well tolerated and showed promising activity in DDLS. The discovery of ANGPTL4 as a late regulator of geroconversion helped to define how CDK4/6i-induced cellular senescence modulates the immune tumor microenvironment and contributes to both positive and negative clinical outcomes.
See related commentary by Weiss et al., p. 649
Fernanda Gomes: eloquência do silêncio
Authors: Drumond Matheus Filipe Alves Madeira 
Published: September 2023

Fernanda Gomes tem se destacado no cenário artístico nacional por apresentar um trabalho pouco dócil ao sistema que o contém. Nosso intento nesta reflexão será demonstrar como sua obra (ou melhor, suas exposições-obras), amplamente perpassada pelas pequenas percepções e pela atenção exaustiva, formula uma estratégia de recepção singular – distinta da fugacidade da atenção hodierna e da intensiva discursividade do campo contemporâneo das artes. A hipótese de uma recepção singular é amparada pela constante recusa em atribuir nomes a obras e exposições (corriqueiramente intituladas com seu próprio nome, mais por insuficiência que por intenção), a insistência em destituir o poder das interferências discursivas curatoriais, sem que com isso suplemente o campo semântico do trabalho com sua própria subjetividade e vida.
Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors
Authors: Cosarderelioglu Caglar , Kreimer Simion , Plaza‐Rodriguez Alma I. , Iglesias Pablo A. , Talbot C. Conover , Siragy Helmy M. , Carey Robert M. , Ubaida‐Mohien Ceereena , O'Rourke Brian , Ferrucci Luigi , Bennett David A. , Walston Jeremy , Abadir Peter 
Published: September 2023

Background
The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ. However, controversy exists about the location, distribution, and expression levels of these receptors. Concerns have been raised over the low sensitivity, low specificity, and large variability between lots of commercially available antibodies for angiotensin type‐1 and type‐2 receptors, which makes it difficult to reconciliate results of different studies. Here, we describe the first non–antibody‐based sensitive and specific targeted quantitative mass spectrometry assay for angiotensin receptors.

Methods and Results
Using a technique that allows targeted analysis of multiple peptides across multiple samples in a single mass spectrometry analysis, known as TOMAHAQ (triggered by offset, multiplexed, accurate mass, high resolution, and absolute quantification), we have identified and validated specific human tryptic peptides that permit identification and quantification of angiotensin type‐1 and type‐2 receptors in biological samples. Several peptide sequences are conserved in rodents, making these mass spectrometry assays amenable to both preclinical and clinical studies. We have used this method to quantify angiotensin type‐1 and type‐2 receptors in postmortem frontal cortex samples of older adults (n=28) with Alzheimer dementia. We correlated levels of angiotensin receptors to biomarkers classically linked to renin‐angiotensin system activation, including oxidative stress, inflammation, amyloid‐β load, and paired helical filament‐tau tangle burden.

Conclusions
These robust high‐throughput assays will not only catalyze novel mechanistic studies in the angiotensin research field but may also help to identify patients with an unbalanced angiotensin receptor distribution who would benefit from angiotensin receptor blocker treatment.