bluuebunny/crossref_metadata_2025_split huggingface dataset:
Makna Mode dalam Film Tenggelamnya Kapal Van Der Wijk
Authors: Nur Ayu Tri Gemilang Masitha , Hendy Bayu P Moch 
Published: July 2023

Film Tenggelamnya Kapal Van Der Wijk sebuah film yang diadaptasi dari novel dengan judul yang sama karya Buya Hamka. Film ini tidak terlepas dari ornamen-ornamen atau aksesoris untuk mendeskripsikan adat Minangkabau, salah satunya adalah mode. Mode yang digunakan tokoh Hayati dan Zainuddin membuat peneliti tertarik untuk meneliti mode yang digunakan oleh dua tokoh tersebut. Adapun permasalahan yang dikaji adalah 1) Bagaimana kode pakaian tokoh Zainuddin dan Hayati dalam film Tenggelamnya Kapal Van Der Wijk? 2) Bagaimana representasi identitas tokoh Zainuddin dan Hayati melalui mode dalam film Tenggelamnya Kapal Van Der Wijk?
Artikel ini akan menggunakan teori semiotik Roland Barthes dan didukung oleh teori Fred Davis. Teori ini digunakan untuk mengungkapkan kode pakaian dan makna dari sebuah mode. Mode bukan sekadar penutup tubuh, aksesoris, dan hiasan, tetap melalui mode seseorang dapat dapat merepresentasikan identitas dirinya. Terlebih lagi mode dapat dijadikan alat untuk mengeskpresikan dan mengomunikasikan diri misalkan, pedeskripsian karakter dan status sosial yang dimiliki individu atau kedua tokoh tersebut. Apalagi tokoh Zainuddin dan Hayati berbeda status sosial dan adat
Exclusive Breastfeeding
Authors: Najahah Imtihanatun 
Published: July 2023

For infants, breast milk is the best food. It is clean and safe, and has antibodies that protect against a variety of common childhood diseases. Breast milk meets all of an infant’s nutrient and energy needs during the first few months of life, and it continues to meet up to one third and up to half of a child’s nutritional requirements during the second half of the first year. Breast milk, here in after abbreviated as breastfeeding, is the liquid produced by the secretion of the mother’s breast glands. Exclusive breastfeeding, is breast milk given to babies from birth for 6 (six) months, without adding and/or replacing it with other food or drinks. Exclusive breastfeeding is that babies are only given breast milk, without additional liquids such as formula milk, orange juice, honey, tea, water and without additional solid foods such as bananas, papaya, milk porridge, biscuits, rice porridge and team, for 6 months. There are many factors to get success exclusive breastfeeding.
The Influence of Undergraduate Preparation on Professional Beginnings in School Practice of Novice Teachers
Authors: Rajsiglová Ina , Mihulová Kateřina 
Published: July 2023

The aim of the chapter is to present how the monitored beginning teachers perceive the influence of undergraduate training on their first years of teaching and what possibilities can be traced based on this to improve the quality of the undergraduate training of future teachers. Thirteen beginning biology teachers with experience ranging from 1 to 5 years were followed. For data triangulation, an elementary school teacher with a completed sixth year in practice without approval with biology and student teachers as part of the focus group were interviewed additionally. Data were obtained through in-depth semi-structured interviews and were analysed using grounded theory. The results show that teaching practices are considered the most valuable component of undergraduate training preparing for a future profession; however, pedagogical practices are included late in undergraduate training and therefore cannot effectively help reduce the “theory-practice” gap in teacher education. Linked to this is the proposal to experience university teaching, for example, through micro-teaching or discussions of real school situations. Thus, they can help to meet the needs of beginning teachers with different experiences, and by mitigating the shock of practice, accelerate the professional teacher development, as was graphically represented by means of intersecting triangles.
ANALISIS POTENSI PORANG SEBAGAI PENGGANTI BERAS UNTUK KETAHANAN PANGAN DI KABUPATEN PANGANDARAN
Authors: Bambang Nurcahya Said , Mulya Mantri Yaya , Hatimatunnisani Hani 
Published: July 2023

Ketahanan pangan menjadi salah satu kunci bertahan suatu negara dimasa krisis paska pandeni covid 19 dan ancaman kekurangan Energi & Pangan akibat perang Rusia- Ukraina. Indonesia mempunyai iklim tropis dimana pertaniannya bisa dikelola dengan mudah dan murah sepanjang tahun. Potensi peningkatan produksi pangan sangat dimungkinkan apabila dilakukan sesuai tata kelola secara benar dan semua pelaku pertanian menjadi bagian dari pengembangan industri pertanian. Tanaman Umbi Porang beberapa tahun ini mulai dibudidayakan oleh petani karena program kementrian Pertanian dan di dukung penuh oleh Presiden, Porang adalah umbi yang bisa tumbuh secara mudah di ladang, kebun, hutan dan pemeliharaanya juga mudah. Untuk itu analisis potensi porang sebagai pengganti beras untuk ketahanan pangan di Kabupaten Pangandaran coba di teliti dengan metode analisis diskriptif dengan menggambarkan yang terkumpul dari hasil wawancara, dan data primer maupun sekunder yang berkaitan dengan budidaya porang. Analisa Potensi ini mengkaji secara ilmiah segala potensi porang dibandingkan dengan beras untuk mengatasi katahanan pangan di Kabupaten Pangandaran. Hasil Penelitian ini kami publikasikan untuk Pemerintah Daerah Kabupaten Pangandaran, Bank BJB, Kadin Kabupaten Pangandaran yang bekerjasama dengan PT.Joglosemar Karangsari Makmur dalam pengembangan Budidaya Porang.Kesimpulan dalam antisipasi harga jual umbi porang ini anjlok maka petani juga wajib di latih untuk bisa membuat produk turunan porang menjadi makanan siap saji sendiri dan memasarkan produk secara digital sehingga mengurangi ketergantungan dari ekspor.
ANALYSIS OF HYDROMETOLOGICAL CONDITIONS IN AZERBAIJAN IN RECENT YEARS (2021-2022) AGAINST MODERN CLIMATE CHANGES
Authors: Mahmudov R.N. , Məmmədova V.İ. , Dadaşova F.S. 
Published: July 2023

Məqalə real hidrometeoroloji müşahidə məlumatlarına əsasən 2021-2022 – ci illərdə regional iqlim dəyişmələrinin respublika ərazisində təhlilinə və onun ölkənin hidrometeoroloji şəraitinə təsirinin tədqiqinə həsr olunmuşdur. Müəyyən olunmuşdur ki, əvvəlki illərdə olduğu kimi 2020 və 2022-ci illərdə də ölkə ərazisində orta illik temperaturlarının artması baş vermişdir və bu müvafiq olaraq +2,10C və +20C təşkil etmişdir. 2021- ci ildə ən çox temperatur artımı 1-200 m və > 1000 m-dən artıq yüksəkliklərdə + 2,2 0C və ən az isə ≤ 0 m-dən aşağı ərazilərdə +1,60C baş vermişdir. Regionlar üzrə isə, ən çox temperatur artımı +2,50C. Kiçik Qafqazda, ən az artım Abşeron-Qobustanda +1,6 0C olmuşdur. 2022-ci ildə isə, orta illik temperatur artımı 2,0 0C olmuş və ən çox artım yenə 1-200 m yüksəklik intervalında +2,2 0C və ən az artım (+1,30C) 501-1000 m yüksəkliklərdə olmuşdur. Regionlar üzrə isə, ən çox artım Naxçıvan MR – də (+2,1 0C), ən az artım Böyük Qafqazda +0,7 0C təşkil etmişdir. Orta illik yağıntının miqdarı azalaraq 2021-ci ildə -134 mm, 2022-ci ildə - 134 mm olmuşdur. Ən çox yağıntı miqdarının azalması 201-500 m yüksəklik intervalında baş vermişdir – 175 mm. Kür çayının – Qıraqkəsəmən məntəqəsində orta illik su sərfi son 10 ildə (2012-2022) 375 m3/s – dən 202 m3/s-ə qədər azalmışdır. Xəzər dənizinin səviyyəsi tədqiq olunan illər ərzində də müvafiq olaraq – 20sm və - 28 sm aşağı düşmüşdür.
The article is devoted to the analysis of regional climate changes on the territory of the republic in 2021-2022. based on the data of real hydro¬me¬teo-rological observations and the study of their influence on the hydrometeorological conditions of the country. It was determined that, as in previous years, in 2020 and 2022 there was an increase in the average annual tem¬perature in the country, which amounted to +2.10С and +2.00С, respectively. In 2021, the largest temperature increase was observed at altitudes of 1-200 m and > 1000 m + 2.20С, and the smallest - in areas below ≤ 0 m + 1.60С. In regions, the maximum temperature rise is +2.50C. In the Lesser Caucasus, the smallest increase was +1.6 0С in Absheron-Gobustan. In 2022, the average annual tempe¬rature increase was +2.0 0С, while the maximum in¬cre¬ase again amounted to +2.2 0С in the altitude range of 1-200 m, and the smallest (+1.30С) regions, the largest in¬crease was in the Nakhchivan MR (+2.10С), the smallest increase was +0.70С in the Greater Caucasus. The average annual precipitation decreased to -134 mm in 2021 and to -134 mm in 2022. The greatest decrease in the amount of precipitation occurred in the altitude range of 201-500 m - 175 mm. The average annual water discharge of the Kura Ri¬ver in the Girakkesaman region over the past 10 years (2012-2022) has decreased from 375 m3/s to 202 m3/s. The level of the Caspian Sea during the years under study decreased by -20 cm and -28 cm, respectively.
Factors Affecting the Achievement of Company Goals by Maximising Company Profits through Internal and External Factors
Authors: Barera Bergi Elber Ernesto 
Published: July 2023

In the current era of globalisation, the development of a company is increasingly sophisticated and rapid. With the increasing number of companies, it will complicate opportunities for companies. In this case the company must innovate to face its competitors. This study aims to examine the factors that influence the achievement of company goals by maximising company profits through internal and external factors. This research is literature research, and the data used is secondary data from various literatures. Qualitative descriptive method is used to assess the data obtained. The results showed that company performance is influenced by external factors, because external factors themselves can be used as opportunities or threats, namely the involvement of government agencies and institutions that facilitate the entire process starting from raw materials, production processes and marketing processes to media devices to improve company performance. This is because the participation of related parties can encourage entrepreneurs to be creative. Thus, business people can make superior and quality products.
Supportive Interventions for Caregivers of Individuals With Multiple Sclerosis: A Systematic Review
Authors: Hoseinpour Fatemeh , Ghahari Setareh , Motaharinezhad Fatemeh , Binesh Maryam 
Published: July 2023

ABSTRACT

BACKGROUND
Caregivers of individuals with multiple sclerosis (MS) are key members of the treatment team. Their needs and challenges should be met as interventions can be effective in improving not only their own health, well-being, and quality of life but also that of those they care for. The aim of this systematic review was to investigate supportive interventions for caregivers of individuals with MS.

METHODS
We conducted a database search of PubMed, Google Scholar, Science Direct, Scopus, and the Cochrane Library from 2000 to 2021. English-language studies that examined interventions administered directly to caregivers of individuals with MS and evaluated various outcomes were included. The Downs and Black checklist was used to assess the methodological quality of included studies.

RESULTS
Twenty of 367 relevant papers fit the eligibility criteria outlined in the methods of this study and were subsequently selected for this review. Of the included studies, there was a notable variance in key characteristics such as methods, outcome measures, sample size, and procedures. Supportive interventions, psychoeducational group interventions, and behavioral-adaptive therapies were the 3 main categories of interventions reviewed; however, each study had a significant correlation between the intervention and outcomes.

CONCLUSIONS
Despite the small sample size in this study, this review showed that various intervention models that target caregivers of individuals with MS have been successful.
Green synthesis of silver nanoparticles using Ocimum sanctum Linn. and its antibacterial activity against multidrug resistant Acinetobacter baumannii
Authors: Gautam Deepan , Dolma Karma Gurmey , Khandelwal Bidita , Gupta Madhu , Singh Meghna , Mahboob Tooba , Teotia Anil , Thota Prasad , Bhattacharya Jaydeep , Goyal Ramesh , M.R. Oliveira Sonia , Pereira Maria de Lourdes , Wiart Christophe , Wilairatana Polrat , Eawsakul Komgrit , Rahmatullah Mohammed , Saravanabhavan Shanmuga Sundar , Nissapatorn Veeranoot 
Published: July 2023

The biosynthesis of nanoparticles using the green route is an effective strategy in nanotechnology that provides a cost-effective and environmentally friendly alternative to physical and chemical methods. This study aims to prepare an aqueous extract of Ocimum sanctum (O. sanctum)-based silver nanoparticles (AgNPs) through the green route and test their antibacterial activity. The biosynthesized silver nanoparticles were characterised by colour change, UV spectrometric analysis, FTIR, and particle shape and size morphology by SEM and TEM images. The nanoparticles are almost spherical to oval or rod-shaped with smooth surfaces and have a mean particle size in the range of 55 nm with a zeta potential of −2.7 mV. The antibacterial activities of AgNPs evaluated against clinically isolated multidrug-resistant Acinetobacter baumannii (A. baumannii) showed that the AgNPs from O. sanctum are effective in inhibiting A. baumannii growth with a zone of inhibition of 15 mm in the agar well diffusion method and MIC and MBC of 32 µg/mL and 64 µg/mL, respectively. The SEM images of A. baumannii treated with AgNPs revealed damage and rupture in bacterial cells. The time-killing assay by spectrophotometry revealed the time- and dose-dependent killing action of AgNPs against A. baumannii, and the assay at various concentrations and time intervals indicated a statistically significant result in comparison with the positive control colistin at 2 µg/mL (P < 0.05). The cytotoxicity test using the MTT assay protocol showed that prepared nanoparticles of O. sanctum are less toxic against human cell A549. This study opens up a ray of hope to explore the further research in this area and to improve the antimicrobial activities against multidrug resistant bacteria.
Patents and Regulatory Exclusivities on GLP-1 Receptor Agonists
Authors: Alhiary Rasha , Kesselheim Aaron S. , Gabriele Sarah , Beall Reed F. , Tu S. Sean , Feldman William B. 
Published: July 2023

ImportanceGlucagon-like peptide 1 (GLP-1) receptor agonists were first approved for the treatment of type 2 diabetes in 2005. Demand for these drugs has increased rapidly in recent years, as indications have expanded, but they remain expensive.ObjectiveTo analyze how manufacturers of brand-name GLP-1 receptor agonists have used the patent and regulatory systems to extend periods of market exclusivity.Evidence ReviewThe annual US Food and Drug Administration’s (FDA) Approved Drug Products With Therapeutic Equivalence Evaluations was used to identify GLP-1 receptor agonists approved from 2005 to 2021 and to record patents and nonpatent statutory exclusivities listed for each product. Google Patents was used to extract additional data on patents, including whether each was obtained on the delivery device or another aspect of the product. The primary outcome was the duration of expected protection from generic competition, defined as the time elapsed from FDA approval until expiration of the last-to-expire patent or regulatory exclusivity.FindingsOn the 10 GLP-1 receptor agonists included in the cohort, drug manufacturers listed with the FDA a median of 19.5 patents (IQR, 9.0-25.8) per product, including a median of 17 patents (IQR, 8.3-22.8) filed before FDA approval and 1.5 (IQR, 0-2.8) filed after FDA approval. Fifty-four percent of all patents listed on GLP-1 receptor agonists were on the delivery devices rather than active ingredients. Manufacturers augmented patent protection with a median of 2 regulatory exclusivities (IQR, 0-3) obtained at approval and 1 (IQR, 0.3-4.3) added after approval. The median total duration of expected protection after FDA approval, when accounting for both preapproval and postapproval patents and regulatory exclusivities, was 18.3 years (IQR, 16.0-19.4). No generic firm has successfully challenged patents on GLP-1 receptor agonists to gain FDA approval.Conclusions and RelevancePatent and regulatory reform is needed to ensure timely generic entry of GLP-1 receptor agonists to the market.
Urine Drug Screening in a Telehealth Setting for the Treatment of Opioid Use Disorder
Authors: Williams Arthur Robin , Rowe Christopher , Gallagher Ryan , Aronowitz Shoshana V. , Diamond-Reivich, Jon , Bisaga Adam 
Published: July 2023

ImportanceAmid rapid and widespread adoption of telehealth-based opioid treatment (TBOT), there is an urgent need for rigorous studies exploring the feasibility and characteristics of urine drug screening (UDS).ObjectiveTo investigate administration patterns and results of UDS to assess feasibility of UDS and patient outcomes in a TBOT setting.DesignThis observational cohort study was conducted between January 1, 2021, and December 6, 2022, and included patients with opioid use disorder treated in Ophelia, a TBOT treatment platform in 14 states. Data analysis was performed from January to March 2023.Main Outcomes and MeasuresNumber and percentage of patients with UDS within 30, 90, and 180 days of intake, grouped by adherence to clinical protocols. Associations were assessed between baseline characteristics and UDS completion and opioid positivity in first 30 days using χ2 tests. Baseline and 180-day follow-up UDS results were compared using McNemar tests.ResultsAmong 3395 patients (mean [SD] age, 38.2 [9.3] years, mostly male [54.1%], non-Hispanic White [81.5%], urban-residing [80.3%], and cash-pay at intake [74.0%]), 2782 (83.3%) completed a UDS within 30 days (90.0% among protocol-adherent patients, 67.0% among protocol-nonadherent patients). A total of 2750 of 2817 (97.6%) patients retained more than 90 days completed 1 or more UDS, as did 2307 of 2314 (99.7%) patients retained more than 180 days. Younger patients, patients of a racial and ethnic minority group, those living in urban areas, and cash-pay patients were less likely to complete a UDS in the first 30 days. Buprenorphine positivity increased (from 96.9% to 98.4%, P = .004) and opioid positivity declined (from 7.9% to 3.3%, P &amp;lt; .001) over time.Conclusions and RelevanceIn this cohort study of patients with opioid use disorder receiving buprenorphine in a remote care environment, UDS was highly feasible, though early UDS completion rates varied across demographic subgroups. The prevalence of unexpected UDS results was low and declined over time in treatment.
Rise of the Chromodomain Helicase DNA‐Binding (CHD) Chromatin Remodelling Machines
Authors: Alendar Andrej 
Published: July 2023

AbstractVital processes such as transcription, repair, replication and recombination continuously shape cellular chromatin landscape. The chromodomain helicase DNA‐binding (CHD) family of enzymes regulate chromatin dynamics by utilising energy from ATP hydrolysis to alter nucleosomal position, structure and composition, thereby modulating accessibility of the underlying DNA sequence. The CHD enzymes are highly conserved in evolution, and genetic studies in fungi, plants and animals demonstrate their critical roles in regulation of cellular identity and fate and organismal development. Advances in genomic studies over the past two decades led to the identification of frequent DNA copy‐number alterations, mutations and aberrant expression of CHDs in human malignancies and various disorders, highlighting their importance as relevant biomarkers or targets for therapeutic intervention.Key ConceptsCHD family of enzymes (CHD1‐9) are evolutionary conserved ATP‐dependent chromatin remodelers that mobilise nucleosomes to regulate DNA‐templated processes, such as transcription, replication and repair. They are critical for normal organismal development and are frequently mutated in human disorders and cancers.Chromodomain helicase DNA‐binding proteins (CHD1‐9) are evolutionary conserved family of ATP‐dependent chromatin remodelers that mobilise nucleosomes to regulate DNA‐templated processes such as transcription, replication and DNA repair.CHD enzymes share a common domain structure: two N‐terminal chromodomains, a central ATPase/helicase domain, and a C‐terminal DNA‐binding domain.CHD proteins play crucial roles in diverse cellular processes, including embryonic development, stem cell maintenance and differentiation, and tissue‐specific gene expression.Dysregulation of CHD proteins has been associated with various human diseases, including cancer and neurodevelopmental disorders.CHD proteins are attractive targets for the development of new therapies for diseases associated with chromatin dysfunction. Understanding the molecular mechanisms underlying the function of CHD proteins may pave the way for the development of new drugs that target these proteins and improve the treatment of a variety of human diseases.
Effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus
Authors: Chiejina Chike Obinna , Ikeh Ifeanyi Mulumba , Enebe Florence A. , Aguzie Ifeanyi Oscar , Ajima Malachy Nwigwe Okechukwu , Ali Daoud , Kumar Gokhlesh , Nwani Christopher Didigwu 
Published: July 2023

Abstract

Objective
The study investigated the effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus.

Methods
Juveniles were exposed to different concentrations of haloperidol (0.12, 0.24, and 0.48 mg/L) for 15 days and subsequently withdrawn from the drug for 5 days. Blood samples from the fish on days 1, 5, 10, and 15 and after the 5-day withdrawal period were analyzed for mutagenic changes, after which the fish were sacrificed. The brain was sampled for serotonergic and dopaminergic analyses.

Result
There was formation of micronuclei in the peripheral fish blood, which increased as the duration and concentrations of the drug increased. The drug significantly reduced the serotonin activity but increased dopamine activity. Some of the studied parameters, however, recovered from the effects of the drug after the 5-day withdrawal period.

Conclusion
Haloperidol is toxic to fish, and its use in the environment should be guarded to avoid adverse impacts on nontarget species like fish.
Adaptive fuzzy finite‐time formation asymptotic tracking control for nonholonomic multirobot systems with inputs quantization
Authors: Dong Shijie , Li Yongming 
Published: July 2023

SummaryThis paper investigates the finite‐time formation tracking control problem for nonholonomic multirobot systems with inputs quantization. The fuzzy logic systems (FLSs) and adaptive method are introduced to approximate unknown nonlinear functions and parameters. Multirobot needs to keep safe and effective communicating range, the barrier function and prescribed performance method are employed to ensure collision avoidance and connectivity maintenance. Then, in order to make each robot more precisely and quickly track referenced leader's trajectory and consider the finite channel bandwidth in practical applications, the travel range of robots can be maintained at more secure region and formation can operate normally within the given bandwidth. By combining the command filter and finite‐time theory, a novel decentralized finite‐time formation asymptotic tracking (FTFAT) control strategy is further proposed based on inputs quantization technology, it guarantees that all signals are bounded and the formation tracking errors asymptotically converge to zero in finite‐time. Finally, the practicability of FTFAT strategy is demonstrated absolutely for nonholonomic multirobot systems.