bluuebunny/crossref_metadata_2025_split huggingface dataset:
El desarrollo sostenible en la conservación de patrimonio arqueológico: los yacimientos de Sant Gregori y Torrucles en Burriana
Authors: Safont Cruz Elvira 
Published: July 2023

Hoy en día es destacable la importancia del desarrollo sostenible en la conservación y restauración del patrimonio, buscando beneficiar a la generación presente sin comprometer los derechos de las futuras generaciones, cuestionando criterios antiguos en favor de enfoques más innovadores y éticos, incluyendo la sostenibilidad. En el presente artículo se realiza una revisión del panorama del desarrollo sostenible dentro del campo de la conservación y restauración del patrimonio histórico-arqueológico, haciendo hincapié en el caso concreto del Museo Arqueológico de Burriana.
El Museo Arqueológico de Burriana, en la provincia de Castellón, realiza diversas labores relacionadas con la conservación y difusión del patrimonio arqueológico de la zona. Se promueve el respeto a la autenticidad de los materiales, la minimización del impacto ambiental y la participación de las comunidades locales, siempre en relación con el desarrollo sostenible.
El enfoque sostenible en la conservación y restauración busca preservar el patrimonio de manera científica y respetuosa, considerando la salud del restaurador y la protección a largo plazo. Desde el proyecto en el Museo Arqueológico de Burriana se realiza un gran esfuerzo por establecer un precedente en el campo de la conservación del patrimonio arqueológico.
Direct estimation of central aortic pressure from measured or quantified mean and diastolic brachial blood pressure: agreement with invasive records
Authors: Bia Daniel , Salazar Federico , Cinca Luis , Gutierrez Marcos , Facta Alvaro , Zócalo Yanina , Diaz Alejandro 
Published: July 2023

BackgroundRecently it has been proposed a new approach to estimate aortic systolic blood pressure (aoSBP) without the need for specific devices, operator-dependent techniques and/or complex wave propagation models/algorithms. The approach proposes aoSBP can be quantified from brachial diastolic and mean blood pressure (bDBP, bMBP) as: aoSBP = bMBP2/bDBP. It remains to be assessed to what extent the method and/or equation used to obtain the bMBP levels considered in aoSBP calculation may affect the estimated aoSBP, and consequently the agreement with aoSBP invasively recorded.MethodsBrachial and aortic pressure were simultaneously obtained invasively (catheterization) and non-invasively (brachial oscillometry) in 89 subjects. aoSBP was quantified in seven different ways, using measured (oscillometry-derived) and calculated (six equations) mean blood pressure (MBP) levels. The agreement between invasive and estimated aoSBP was analyzed (Concordance correlation coefficient; Bland-Altman Test).ConclusionsThe ability of the equation “aoSBP = MBP2/DBP” to (accurately) estimate (error &lt;5 mmHg) invasive aoSBP depends on the method and equation considered to determine bMBP, and on the aoSBP levels (proportional error). Oscillometric bMBP and/or approaches that consider adjustments for heart rate or a form factor ∼40% (instead of the usual 33%) would be the best way to obtain the bMBP levels to be used to calculate aoSBP.
“The library is so much more than books”: considerations for the design and implementation of teen digital mental health services in public libraries
Authors: Knapp Ashley A. , Hersch Emily , Wijaya Clarisa , Herrera Miguel A. , Kruzan Kaylee P. , Carroll Allison J. , Lee Sydney , Baker Alex , Gray Alanna , Harris Vann , Simmons Robert , Kour Sodhi Deepika , Hannah Nanette , Reddy Madhu , Karnik Niranjan S. , Smith Justin D. , Brown C. Hendricks , Mohr David C. 
Published: July 2023

BackgroundAdolescence is a vulnerable developmental period, characterized by high rates of mental health concerns, yet few adolescents receive treatment. Public libraries support adolescents by providing them with access to teen programming, technological resources, and have recently been providing mental health services. Digital mental health (DMH) services may help libraries provide scalable mental health solutions for their adolescent patrons and could be well positioned to address the mental health needs of historically underrepresented racial and ethnic (HURE) adolescents; however, little research has been conducted on the compatibility of DMH services with adolescent patron mental health needs or resource needs of library workers supporting them.MethodsThe research team formed a partnership with a public library, which serves a large HURE adolescent population. We conducted needs assessment and implementation readiness interviews with 17 library workers, including leadership, librarians, and workers with specialized areas of practice. Interview questions focused on library infrastructure, as well as library needs and preferences around the design and implementation of DMH services for adolescents. We used the Consolidated Framework for Implementation Research as guiding implementation determinant framework to code and analyze the interview transcripts.ResultsOur findings revealed library workers play an important role in guiding patrons to desired resources and share a goal of implementing adolescent DMH resources into the library and elevating marginalized adolescents’ voices. Existing library resources, such as the library's role as a safe space for adolescents in the community, close relationships with external and community organizations, and availability of no-cost technological resources, could help facilitate the implementation of DMH services. Barriers related to community buy-in, mental health stigma, and library worker confidence in supporting adolescent mental health could affect service implementation.ConclusionsOur findings suggest public libraries are highly promising settings to deploy DMH services for adolescents. We identified important determinants that may impact the implementation of DMH services in public library settings. Special considerations are needed to design services to meet the mental health needs of HURE adolescent populations and those adolescents’ most experiencing health inequities.
An investigation of media reports of digital surveillance within the first year of the COVID-19 pandemic
Authors: Comer Leigha , Donelle Lorie , Ngole Marionette , Shelley Jacob J. , Kothari Anita , Smith Maxwell , Shelley James M. , Stranges Saverio , Hiebert Brad , Gilliland Jason , Burkell Jacquelyn , Cooke Tommy , Hall Jodi , Long Jed 
Published: July 2023

IntroductionThe COVID-19 pandemic prompted a surge in digital public health surveillance worldwide, with limited opportunities to consider the effectiveness or impact of digital surveillance. The news media shape public understanding of topics of importance, contributing to our perception of priority issues. This study investigated news media reports published during the first year of the pandemic to understand how the use and consequences of digital surveillance technologies were reported on.MethodsA media content analysis of 34 high- to low-income countries was completed. The terms “COVID-19,” “surveillance,” “technologies,” and “public health” were used to retrieve and inductively code media reports.ResultsOf the 1,001 reports, most were web-based or newspaper sources on the development and deployment of technologies directed at contact tracing, enforcing quarantine, predicting disease spread, and allocating resources. Technology types included mobile apps, wearable devices, “smart” thermometers, GPS/Bluetooth, facial recognition, and security cameras. Repurposed data from social media, travel cards/passports, and consumer purchases also provided surveillance insight. Media reports focused on factors impacting surveillance success (public participation and data validity) and the emerging consequences of digital surveillance on human rights, function creep, data security, and trust.DiscussionDiverse digital technologies were developed and used for public health surveillance during the first year of the COVID-19 pandemic. The use of these technologies and witnessed or anticipated consequences were reported by a variety of media sources worldwide. The news media are an important public health information resource, as media outlets contribute to directing public understanding and shaping priority public health surveillance issues. Our findings raise important questions around how journalists decide which aspects of public health crises to report on and how these issues are discussed.
Operational snow-hydrological modeling for Switzerland
Authors: Mott Rebecca , Winstral Adam , Cluzet Bertrand , Helbig Nora , Magnusson Jan , Mazzotti Giulia , Quéno Louis , Schirmer Michael , Webster Clare , Jonas Tobias 
Published: July 2023

The seasonal evolution of snow cover has significant impacts on the hydrological cycle and microclimate in mountainous regions. However, snow processes also play a crucial role in triggering alpine mass movements and flooding, posing risks to people and infrastructure. To mitigate these risks, many countries use operational forecast systems for snow distribution and melt. This paper presents the Swiss Operational Snow-hydrological (OSHD) model system, developed to provide daily analysis and forecasts on snow cover dynamics throughout Switzerland. The OSHD system is a sophisticated snow hydrological model designed specifically for the high-alpine terrain of the Swiss Alps. It leverages exceptional station data and high-resolution meteorological forcing data, as well as various reanalysis products to combine snow modeling with advanced data assimilation and meteorological downscaling methods. The system offers models of varying complexity, each tailored to specific modeling strategies and applications. For snowmelt runoff forecasting, monitoring snow water resources, and research-grade purposes, the OSHD system employs physics-based modeling chains. For snow climatological assessments, a conceptual model chain is available. We are pleased to present two comprehensive datasets from the conceptual and physics-based models that cover the entirety of Switzerland. The first dataset comprises a snow water equivalent climatology spanning 1998–2022, with a spatial resolution of 1 km. The second dataset includes snow distribution and snow melt data spanning 2016–2022 at a high spatial resolution of 250 m. To meet the needs of a multi-purpose snow hydrological model framework, the OSHD system employs various strategies for process representation and sub-grid parameterizations at the snow-canopy-atmosphere interface, particularly in complex terrain. Recent and ongoing model developments are aimed at accounting for complex forest snow processes, representing slope and ridge-scale precipitation and snow redistribution processes, as well as improving probabilistic snow forecasts and data assimilation procedures based on remote sensing products.
Evaluation of hormonal and circulating inflammatory biomarker profiles in the year following bariatric surgery
Authors: Kim Eun Ran , Yun Ji Ho , Kim Hyo-Jin , Park Hyeon Young , Heo Yoonseok , Park Young Suk , Park Do Joong , Koo Soo Kyung 
Published: July 2023

BackgroundBariatric surgery (BS) has a superior effect on reducing body weight and fat in patients with morbid obesity. As a result, BS mitigates obesity-related complications such as type 2 diabetes (T2D). However, few studies have shown the mechanism underlying diabetes remission after surgery. This study aimed to investigate the differences in serum hormone and inflammatory cytokine levels related to diabetes before surgery and during 12 months of follow-up in Korean patients with obesity.MethodsThe study participants were patients with morbid obesity (n=63) who underwent sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) between 2016 – 2017 at seven tertiary hospitals in Korea. The patients were followed for 1 year after surgery.ResultsSixty-three patients had significant weight loss after surgery and showed improvements in clinical parameters and hormonal and inflammatory profiles. Among them, 23 patients who were diabetic preoperatively showed different remission after surgery. The levels of inflammation-related clinical parameters changed significantly in the remission group, and serum inflammatory cytokine and hormones significantly decreased at certain points and showed an overall decreasing trend.ConclusionsOur study found postoperative changes of factors in blood samples, and the changes in hormones secreted from the three major metabolic tissue (pancreas, adipose, and gut) along with the differences in multi-origin inflammatory cytokines between remission and non-remission groups provide a path for understanding how the effect of BS in improving glucose metabolism is mediated.
Rosiglitazone has a null association with the risk of prostate cancer in type 2 diabetes patients
Authors: Tseng Chin-Hsiao 
Published: July 2023

BackgroundThis study investigated the risk of prostate cancer in ever users and never users of rosiglitazone in diabetes patients in Taiwan.MethodsThe nationwide database of the National Health Insurance was used to enroll male patients who had a new diagnosis of type 2 diabetes mellitus at an age ≥ 25 years from 1999 to 2005. A total of 11,495 ever users and 11,495 never users of rosiglitazone matched on propensity score were selected and they were followed up for the incidence of prostate cancer from January 1, 2006 until December 31, 2011. Cox proportional hazard model incorporated with the inverse probability of treatment weighting using the propensity score was used to estimate hazard ratios.ResultsAt the end of follow-up, incident cases of prostate cancer were found in 84 never users and 90 ever users of rosiglitazone. The calculated incidence was 173.20 per 100,000 person-years in never users and was 187.59 per 100,000 person-years in ever users. The overall hazard ratio (95% confidence intervals) for ever versus never users was 1.089 (0.808-1.466). The hazard ratios were 0.999 (0.643-1.552) for the first tertile (&lt; 672 mg), 1.147 (0.770-1.709) for the second tertile (672-3584 mg) and 1.116 (0.735-1.695) for the third tertile (&gt; 3584 mg) of cumulative dose. Sensitivity analyses consistently showed a null association between rosiglitazone and prostate cancer risk.ConclusionRosiglitazone has a null effect on the risk of prostate cancer.
Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis
Authors: Nibeyro Guadalupe , Baronetto Veronica , Folco Juan I. , Pastore Pablo , Girotti Maria Romina , Prato Laura , Morón Gabriel , Luján Hugo D. , Fernández Elmer A. 
Published: July 2023

IntroductionIdentification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases.MethodsHere, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I presentation and positive/negative immune response (ITSNdb), sixteen metrics were evaluated as immunogenicity predictors. In addition, by using a dataset emulating patient derived TSNs and immunotherapy cohorts containing predicted TSNs for tumor neoantigen burden (TNB) with outcome association, the metrics were evaluated as TSNs prioritizers and as immunotherapy response biomarkers.ResultsOur results show high performance variability among methods, highlighting the need for substantial improvement. Deep learning predictors were top ranked on ITSNdb but show discrepancy on validation databases. In overall, current predicted TNB did not outperform existing biomarkers.ConclusionRecommendations for their clinical application and the ITSNdb are presented to promote development and comparison of computational TSNs immunogenicity predictors.
Stroke in mitral valve prolapse: risk factors and left atrial function in cryptogenic versus non-cryptogenic ischemic subtypes
Authors: Calicchio Francesca , Lim Lisa J. , Cross Danielle , Bibby Dwight , Fang Qizhi , Meisel Karl , Schiller Nelson B. , Delling Francesca N. 
Published: July 2023

Background and purposeMitral valve prolapse (MVP) has been associated with an increased risk of ischemic stroke. Older age, thicker mitral leaflets, and significant mitral regurgitation (MR) leading to atrial fibrillation have been traditionally considered risk factors for ischemic stroke in MVP. However, specific risk factors for MVP-stroke subtypes are not well defined. The aim of this study is to evaluate clinical and echocardiographic parameters, including left atrial (LA) function, in MVP with cryptogenic (C) vs. non-cryptogenic (NC) stroke.MethodsIn this case-control matched study, MVPs were identified in consecutive echocardiograms obtained after a stroke from January 2013 to December2016 at the University of California, San Francisco. MVP was defined as leaflet displacement ≥2 mm in the parasternal long-axis view at end-systole. Age/gender matched MVPs without stroke and healthy controls without MVP were also identified. We analyzed LA end-systolic/diastolic volume index, emptying fraction (LAEF), function index (LAFI), and global longitudinal strain in all MVPs and controls. We also measured left ventricular (LV) volume indexes, mass index, ejection fraction (EF), degree of MR and leaflet thickness.ResultsWe identified a total of 30 MVPs (age 70 ± 12, 50% females) with stroke (11 with C- and 19 with NC-stroke), 20 age/gender matched MVPs without a stroke and 16 controls. MVPs without stroke had lower BMI, less hypertension but more MR (≥moderate in 45% vs. 17%), more abnormal LA function (lower LAEF, LAFI) and larger LV volumes/mass (all p &lt; 0.05) when compared to MVPs with stroke. Leaflet thickness was overall mild (&lt;3 mm) and similar in the 2 groups. Within the MVP stroke group, NC-stroke had higher BMI, more hypertension and more atrial fibrillation compared to C-stroke. In the variables tested, patients with C-stroke did not differ from controls.ConclusionsMVP-related MR may be protective against stroke despite abnormal LA function. Risk of NC-stroke in MVP is related to common stroke risk factors rather than mitral valve leaflet thickness. The etiology of C-stroke in MVP warrants further studies.
Correlation of blood pressure levels at different time periods throughout the day with total CSVD burden and MRI imaging markers
Authors: Yang Hua , Fan Xueyi , Shen Xiangyi , Liang Li , Hu Dongyang , Zhang Yimo , Liu Li , Qian Hairong 
Published: July 2023

PurposeHypertension is an important risk factor for atherosclerotic cerebral small vessel disease (CSVD). Higher blood pressure is associated with a higher CSVD burden and the presence of relevant magnetic resonance imaging (MRI) markers. However, the effect of blood pressure level on CSVD burden and imaging markers including white matter hyperintensity (WHM), lacune, enlarged perivascular spaces (EPVS), and cerebral microbleed (CMB) remains unknown. The purpose of this study was to investigate the correlation between blood pressure level and CSVD burden at different time periods throughout the day.MethodsIn total, 144 in-patients with CSVD (66.4 ± 9.8 years, 50% male) were enrolled and underwent brain MRI, and 24-h ambulatory blood pressure was assessed. Patients were categorized into five groups according to their MRI-evaluated total CSVD burden scores (0–4). Spearman's correlation analysis was performed to examine the correlation between blood pressure levels at different time periods and the total CSVD score or the markers of periventricular WMH, deep WMH, lacune, EPVS, and CMB.ResultsOf the 144 patients, 83.3% (120/144) harbored one or more CSVD markers of interest. The systolic blood pressure (SBP) of 24-h, daytime, nighttime, and morning differed significantly among the five groups. The SBP levels increased significantly with the total CSVD scores during 24 h (P = 0.018), daytime (P = 0.018), and nighttime (P = 0.035). Spearman's correlation analysis demonstrated that the SBP of 24 h, daytime, nighttime, and morning and the diastolic blood pressure (DBP) of 24 h and morning positively and significantly correlated with the total CSVD score (P &lt; 0.05). A logistic regression analysis indicated that both morning SBP and DBP were independent risk factors for total CSVD burden (OR = 1.13, 95% CI: 1.02–1.23, P = 0.015; OR = 1.19, 95% CI: 1.06–1.33, P = 0.005). Spearman's correlation analysis indicated a significant positive correlation between morning SBP and higher deep WMH Fazekas score (r = 0.296, P &lt; 0.001), EPVS grade in the basal ganglia (r = 0.247, P = 0.003), and the presence of lacune (r = 0.173, P = 0.038) and CMB (r = 0.326, P &lt; 0.001). Morning DBP only correlated positively with the presence of CMB (r = 0.292, P &lt; 0.001).ConclusionHigher SBP signficantly correlated with total CSVD burden in patients with atherosclerotic CSVD. Early morning blood pressure level is an important indicator to reflect the severity of CSVD patients.
Parental determinants associated with early growth after the first year of life by race and ethnicity
Authors: Aguayo Liliana , Chang Cecilia , McCormack Luke R. , Shalowitz Madeleine U. 
Published: July 2023

ObjectiveTo investigate maternal and parental factors associated with changes in children's body mass index percentile (BMI-P) from 12 to 24 months.MethodsData from a prospective cohort of racially and ethnically diverse mothers, fathers, and children (n = 245) were used. Changes in BMI-P from 12 to 24 months of age were examined using height and weight measurements collected at both times. Separate longitudinal mixed-effects models with maximum likelihood were introduced to examine the determinants introduced by mothers and determinants from both parents among all children, and by race and ethnicity.ResultsModels that examine maternal and parental factors showed that children's overall BMI-P decreased from 12 to 24 months [β = −4.85, 95% confidence interval (CI), −7.47 to −2.23]. Stratified tests showed that White children whose parents graduated high school or completed a 4-year college degree or higher had greater decreases in BMI-P than White children born to parents with less than high school education (β = −60.39, 95% CI, −115.05 to −5.72; β = −61.49, 95% CI, −122.44 to −0.53). Among Hispanic/Latinx children, mean BMI-P significantly decreased from 12 to 24 months (β = −7.12, 95% CI, −11.59 to −2.64). Mother's older age (β = 1.83, 95% CI, 0.29–3.36) and child female sex (β = 11.21, 95% CI, 1.61–20.82) were associated with gains in children's BMI-P, while father's older age was associated with decreases (β = −1.19, 95% CI, −2.30 to −0.08).ConclusionsParental determinants associated with children's early growth varied by children's sex and racial and ethnic background. Results highlight the importance of understanding racial and ethnicity-specific obesity risks and including fathers in research.