bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Terapi Swedish Massage sebagai Upaya Penurunan Tekanan Darah pada Pasien Hipertensi: Kajian Literatur
Authors: Raditya Anindya Petra Bagas , Anggraini Stefani Vista Ayu , Kusumawati Vinda Dolorosana , Juhdeliena Juhdeliena 
Published: May 2023

Hypertension is one of the causes of the highest morbidity in the world. In Indonesia, the prevalence rate of hypertension in 2018 reached 34.1% for the population over 18 years of age. There are various efforts that can be made to lower the blood pressure in hypertensive patients, one of which is Swedish massage therapy. Swedish massage therapy is an act of doing massage through effleurage, petrissage, friction, tapotement, and vibration techniques on certain parts of the body for a relaxing effect to lower blood pressure through the release of the hormones adrenaline in the parasympathetic system. This study aimed to determine the effectiveness of Swedish massage therapy as an effort to reduce blood pressure in hypertensive patients. This study uses a literature review design. The data used were taken from two databases, Google Scholar and Research Gate, using boolean AND, and were searched based on specified inclusion and exclusion criteria. Article search results is presented in the PRISMA diagram. The articles obtained are then performed Critical Appraisal and due diligence using Joanna Briggs Institute (JBI) tools, then analysed using the simplified thematic approach. The search results obtained as many as 555 articles on Google Scholar and 36 articles on Research Gate, bringing a total of 591 articles and a total of six articles were researched. In conclusion, Swedish massage therapy is effective in lowering blood pressure in hipertensive patients
Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured Bone
Authors: Florio Monica , Kostenuik Paul J. , Stolina Marina , Asuncion Franklin J. , Grisanti Mario , Ke Hua Zhu , Ominsky Michael S. 
Published: May 2023

Background:
Fracture repair involves the reactivation of developmental signaling cascades, including Wnt signaling that stimulates bone formation and bone regeneration. Rodent data indicate that dual inhibition of the Wnt signaling antagonists sclerostin and Dickkopf-1 (DKK1) increases callus bone volume and strength while increasing bone mass systemically.

Methods:
We evaluated the effects of 16 weeks of subcutaneously administered carrier solution (vehicle, VEH), anti-sclerostin antibody (Scl-Ab), anti-DKK1 antibody (DKK1-Ab), or Scl-Ab plus DKK1-Ab combination therapy (COMBO) on ulnar osteotomy healing in nonhuman primates (cynomolgus monkeys; 20 to 22 per group).

Results:
Scl-Ab and COMBO therapy increased systemic markers of bone formation versus VEH, with COMBO leading to synergistic increases versus Scl-Ab or DKK1-Ab monotherapies. The COMBO and Scl-Ab groups showed reduced serum markers of bone resorption versus VEH. The COMBO and DKK1-Ab groups exhibited greater callus bone mineral density (BMD), torsional stiffness, and torsional rigidity versus VEH. Lumbar vertebrae from the Scl-Ab and COMBO groups showed greater BMD and bone formation rate versus VEH, and the femoral mid-diaphysis of the Scl-Ab and COMBO groups showed greater periosteal and endocortical bone formation rates versus VEH.

Conclusions:
DKK1-Ab increased BMD and strength at the ulnar osteotomy site, Scl-Ab increased bone formation and BMD at uninjured skeletal sites, and Scl-Ab plus DKK1-Ab combination therapy induced all of these effects, in some cases to a greater degree versus 1 or both monotherapies. These results in nonhuman primates suggest that DKK1 preferentially regulates bone healing while sclerostin preferentially regulates systemic bone mass.

Clinical Relevance:
Combination therapy with antibodies against sclerostin and DKK1 may offer a promising therapeutic strategy for both fracture treatment and fracture prevention.
Desain Level Berbasis Storyboard Pada Perancangan Game Edukasi Augmented Reality Tap The Trash
Authors: Nendya Matahari Bhakti , Susanto Budi , Tamtama Gabriel Indra Widi , Wijaya Timotius Johan 
Published: May 2023

Abstrak
Desain level merupakan sebuah proses dimana membuat pengalaman bermain yang menarik bagi pemain. Desain level mengkombinasikan berbagai macam elemen yang berupa level, mekanik, grafik dan suara. berbagai macam teknik desain level telah dikembangkan dan diimplementasikan dalam game baik 2D maupun 3D. Penelitian ini mencoba mengimplementasikan desain level pada game berbasis augmented reality. Dalam penyusunan level digunakan teknik storyboard yang umumnya dipakai dalam industri film dan televisi. Desain storyboard mengacu pada model storyboard experimental dimana model ini digunakan untuk memberikan perintah pada obyek tertentu. Hasil yang didapatkan model storyboard dapat diimplementasikan pada game dengan menggunakan flutter dan ARCore. Hasil pengujiannya menandakan adanya dinamika level dimana semakin tinggi levelnya maka player akan mengalami kesulitan dalam menyelesaikan objective game.
Kata kunci: level desain, storyboard, game, augmented reality, fluter, ARCore

Abstract
[An approach to level design based on storyboards in augmented reality educational games: Tap The Trash]. The level design aims to provide players with an engaging gaming experience. Designing levels involves combining various elements, such as mechanics, graphics, and sounds. There are a variety of level design techniques that can be applied both in 2D and 3D games. A study of level design for augmented reality-based games is presented in this paper. The levels are prepared using storyboarding techniques, commonly employed in the film and television industries. An experimental storyboard model uses a storyboard to give orders to various objects within a story. With Flutter and ARCore, games can be developed based on the results obtained by the storyboard model. Test results indicate that completing the objective game becomes more difficult as the level is raised.
Keywords: design level, storyboard, game, augmented reality, fluter, ARCore
Analisis Tingkat Pengetahuan Dan Aplikasi Siaga Bencana Kebakaran Pada Civitas Akademika Universitas X
Authors: Rudyarti Edwina 
Published: May 2023

Penilaian kesiapsiagaan bencana kebakaran yang diukur melalui tingkat pengetahuan, sikap, dan tindakan sangat penting agar dapat meminimalisir risiko jika terjadi kebakaran. Penelitian ini bertujuan untuk mengetahui tingkat kesiapsiagaan civitas akademika dalam menghadapi ancaman bencana kebakaran. Metode penelitian menggunakan survei analitik dengan pendekatan cross sectional. Analisis data menggunakan analisis data secara kuantitatif dengan menggunakan Program SPSS. Sampel penelitian ini adalah civitas akademika Universitas X diantaranya diambil sampel penelitian dengan jumlah 55 orang mahasiswa, 30 orang dosen dan 15 orang staff. Hasil penelitian tingkat pengetahuan seluruh civitas akademika mengenai kesiapsiagaan dalam menghadapi bencana kebakaran menunjukkan hasil dengan frequensi paling tinggi kategori sedang dengan prosentase 63,3% untuk dosen, dan 66,7% untuk mahasiswa, dan di 72,7% untuk staff, jadi dapat dikatakan bahwa civitas akademika memiliki tingkat pengetahuan mayoritas adalah sedang, dan pengetahuan tentang aplikasi bencana juga tergolong sedang, sedangkan sikap dan kepedulian seluruh civitas akademika terhadap risiko kebakaran menyatakan sangat setuju dengan kebijakan, peraturan yang akan dibuat, sehingga dapat disimpulkan bahwa kesiapsiagaan bencana kebakaran pada civitas akademika masih kurang. Diperlukan komitmen bersama antara manajemen dan anggota institusi untuk memperkuat pengetahuan dan penerapan kesiapsiagaan bencana kebakaran
Photo-elasticity of silk fibroin harnessing whispering gallery modes
Authors: Korakas Nikolaos , Vurro Davide , Tsilipakos Odysseas , Vasileiadis Thomas , Graczykowski Bartlomiej , Cucinotta Annamaria , Selleri Stefano , Fytas George , Iannotta Salvatore , Pissadakis Stavros 
Published: May 2023

Abstract
Silk fibroin is an important biomaterial for photonic devices in wearable systems. The functionality of such devices is inherently influenced by the stimulation from elastic deformations, which are mutually coupled through photo-elasticity. Here, we investigate the photo-elasticity of silk fibroin employing optical whispering gallery mode resonation of light at the wavelength of 1550 nm. The fabricated amorphous (Silk I) and thermally-annealed semi-crystalline structure (Silk II) silk fibroin thin film cavities display typical Q-factors of about 1.6x104. Photo-elastic experiments are performed tracing the TE and TM shifts of the whispering gallery mode resonances upon application of an axial strain. The strain optical coefficient K’ for Silk I fibroin is found to be 0.059±0.004, with the corresponding value for Silk II being 0.129±0.004. Remarkably, the elastic Young’s modulus, measured by Brillouin light spectroscopy, is only about 4% higher in the Silk II phase. However, differences between the two structures are pronounced regarding the photo-elastic properties due to the onset of β-sheets that dominates the Silk II structure.
No significant effect of mortality salience on unconscious ethnic bias among the Japanese
Authors: Otsubo Kai , Yamaguchi Hiroyuki 
Published: May 2023

Abstract
Objective
Terror management theory posits that when mortality is salient, individuals attempt to defend their cultural worldviews. Although numerous studies have confirmed this hypothesis, some recent studies have suggested that East Asians do not engage in worldview defense. We conducted a pre-registered experiment with 895 Japanese adults to investigate whether they exhibited worldview defense at an unconscious level. Participants performed the Implicit Association Test using Japanese and Korean surnames as stimuli after being primed with thoughts about mortality.
Results
The results revealed that mortality salience had no influence on implicit ethnic bias. These findings support the notion that East Asians do not engage in worldview defense, in accord with recent criticism of the validity of terror management theory. We discuss the limitations and implications of our findings.
Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients
Authors: Shinozaki Koichiro , Yu Pey-Jen , Zhou Qiuping , Cassiere Hugh A. , John Stanley , Rolston Daniel M. , Garg Nidhi , Li Timmy , Johnson Jennifer , Saeki Kota , Goto Taiki , Okuma Yu , Miyara Santiago J. , Hayashida Kei , Aoki Tomoaki , Wong Vanessa K. , Molmenti Ernesto P. , Lampe Joshua W. , Becker Lance B. 
Published: May 2023

Abstract
Objective: Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ), we aimed to continuously measure these metabolic indicators and compare the values between post-cardiothoracic surgery and critical care patients.
Methods: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital. Age 18 years or older healthy volunteers and patients who underwent mechanical ventilation were enrolled.
Results: We included 4 post-surgery and 6 critical care patients. Of those, 3 critical care patients died. The longest measurement reached to 12 hrs and 15 minutes and 50 cycles of repeat measurements were performed. VO2 of the post-surgery patients were 234 +/- 14, 262 +/- 27, 212 +/- 16, and 192 +/- 20 mL/min, and those of critical care patients were 122 +/- 20, 189 +/- 9, 191 +/- 7, 191 +/- 24, 212 +/- 12, and 135 +/- 21 mL/min, respectively. The value of VO2 was more variable in the post-surgery patients and the range of each patient was 44, 126, 71, and 67, respectively. Generalized linear mixed-effect model identified that the post-surgery patients had higher VO2 than the critical care patients (p<0.01). The post-surgery patients also had higher VCO2 than critical care patients (p<0.01). There were no significant differences in RQ between the two groups.
Conclusions: We developed an accurate system that enables continuous and repeat measurements of VO2, VCO2, and RQ. Critical care patients may have less activity in metabolism represented by lower values of VO2 and VCO2, which were less variable over time as compared to those of post-cardiothoracic surgery patients.
Coded aperture snapshot spectral imaging fundus camera
Authors: Zhao Ruixuan , Yang Chengshuai , Gao Liang 
Published: May 2023

Abstract
Spectral imaging holds great promise for the non-invasive diagnosis of retinal diseases. However, to acquire a spectral datacube, conventional spectral cameras require extensive scanning, leading to a prolonged acquisition. Therefore, they are inapplicable to retinal imaging because of the rapid eye movement. To address this problem, we built a coded aperture snapshot spectral imaging fundus camera, which captures a large-sized spectral datacube in a single exposure. Moreover, to reconstruct a high-resolution image, we developed a robust deep unfolding algorithm using a state-of-the-art spectral transformer in the denoising network. We demonstrated the system performance on both standard targets and an eye phantom.
Mental health and psychosocial situation of children and adolescents in Jordan before and after the COVID-19 pandemic: A scoping review
Authors: Tanaka Eizaburo , Khader Yousef , Izutsu Takashi , Hamawi Rana Al , Al-Faouri Taimaa , Tsutsumi Atsuro 
Published: May 2023

AbstractBackgroundJordan has been developing its mental health systems in collaboration with the World Health Organization since 2008. In 2018, child and adolescent mental health was included in the Jordanian National Mental Health and Substance Use Action Plan. In addition, a joint effort between Japan and Jordan is ongoing since 2021 to strengthen the mental health care for children and adolescents. This review aims to summarise the existing literature for better comprehension of the current mental health situation of children and adolescents in Jordan.MethodsA scoping review was conducted to map the mental health and psychosocial issues of children and adolescents in Jordan. Peer-reviewed articles published between 2016 and 2022 were systematically searched in PubMed, PsychINFO, Global Health, and Embase databases. The data were summarised thematically. A meta-analysis was conducted to evaluate the prevalence of depression and anxiety. The study protocol was registered prospectively at the University Hospital Medical Information Network-Clinical Trials Registry (registration number UMIN000046513) on 31st December, 2021.ResultsA total of 53 studies were identified. Depression was the most examined mental health problem. The prevalence of depression varied greatly, from 9.5–73.8%. The meta-analysis showed that the overall pooled prevalence of depression was 34.0%, with 95% confidence intervals of 27.4–40.6. The subgroup analysis of depression prevalence (general population before and after the COVID-19 pandemic: 31.7% and 48.3%, respectively) implied a possible deterioration of mental health of the youth. In addition to depression, mental health issues such as emotional/behavioural symptoms, anxiety, post-traumatic stress disorder (PTSD), attention-deficit/hyperactivity disorder (ADHD), eating disorders, and substance use have been discussed in the literature. Although three studies addressed mental health and psychosocial interventions, none demonstrated efficacy.ConclusionsThis scoping review highlights the potentially high prevalence of mental health issues among children and adolescents in Jordan despite the huge heterogeneity among the selected studies. In addition, it shows a probable deterioration in mental health during the COVID-19 pandemic; there is limited evidence of mental health and psychosocial interventions for this population. Further large-scale epidemiological studies are required to understand the current mental health situation of children and adolescents in Jordan.
Weighted Spin Torque Nano-Oscillator System for Neuromorphic Computing
Authors: Böhnert Tim , Rezaeiyan Yasser , Claro Marcel , Benetti Luana , Jenkins Alex , Farkhani Hooman , Moradi Farshad , Ferreira Ricardo 
Published: May 2023

Abstract
Here we show the weighted spin torque nano-oscillator (WSTNO) as a programmable building block for the next-generation neuromorphic computing systems. The WSTNO is a spintronic circuit composed of two spintronic devices made of magnetic tunnel junctions (MTJs): non-volatile magnetic memories acting as synapses and non-linear spin torque nano-oscillator (STNO) acting as a neuron. Both MTJ types are fabricated from a multifunctional MTJ stack in a single fabrication process, which allows close proximity of the devices, reduces the footprint and is compatible with monolithic integration on top of CMOS technology. The non-linear output based on the weighted sum of the inputs is demonstrated in a proof-of-principle implementation of the WSTNO using three MTJs. The oscillator shows an output power above 3 µW and frequencies of 240 MHz. Multidisciplinary: physics, material science, electrical engineering, spintronics, neuromorphic computation
Insufficient SIRT1 in macrophages promotes oxidative stress and inflammation during scarring
Authors: He Ting , Bai Xiaozhi , Li Yan , Zhang Dongliang , Xu Zhigang , Yang Xuekang , Hu Dahai , Han Juntao 
Published: May 2023

Abstract
Background Macrophage is a critical regulator in wound healing and scar formation, and SIRT1 is related to macrophage activation and polarization, while the specific mechanism is still unclear.Methods To explore the specific effects of SIRT1 in scarring, we established skin incision mice model and LPS induced inflammation cell model. The expression of SIRT1 in tissue and macrophage was detected, and level of SIRT1 was changed to observe the downstream effects. LPS-induced macrophages with or without SIRT1 deficiency were used for TMT-based quantitative proteomic analysis.Results SIRT1 was suppressed in scar while increased in macrophages of scar tissue. And macrophages were proven to be necessary for wound healing. In the early stage of wound healing, knockout of SIRT1 in macrophage could greatly strengthen inflammation and finally promote scarring. NADH-related activities and oxidoreductase activities were differentially expressed in TMT-based quantitative proteomic analysis. We confirmed that ROS production and NOX2 level were elevated after LPS stimulation while the Nrf2 pathway and the downstream proteins, such as Nqo-1 and HO-1, were suppressed. In contrast, the suppression of SIRT1 strengthened this trend. The NF-κB pathway was remarkably activated compared with the control group.Conclusions Insufficient increase of SIRT1 in macrophage leads to over activated oxidative stress and activates NF-κB pathways, which then promotes inflammation in wound healing and scarring. Further increasing SIRT1 in macrophages could be a promising method to alleviate scarring.
Injury-experienced satellite cells retain long-term enhanced regenerative capacity
Authors: Morroni Jacopo , Benedetti Anna , Riera Carles Sanchez , Giordani Lorenzo , Bouche Marina , Lozanoska-Ochser Biliana 
Published: May 2023

Abstract
Background
Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads to a faster and stronger responses upon secondary challenge. Whether previous muscle injury is associated with altered responses to subsequent injury by satellite cells (SCs), the muscle stem cells, is not known.
Methods
we used a mouse model of repeated muscle injury, in which intramuscular cardiotoxin (CTX) injections were administered 50 days apart in order to allow for full recovery of the injured muscle before the second injury. The effect of prior injury on the phenotype, proliferation and regenerative potential of satellite cells following a second injury was examined in vitro and in vivo by immunohistochemistry, RT-qPCR, WB, and histological analysis.
Results
We show that SCs isolated from muscle at 50 days post- injury (‘injury-experienced SCs (ieSCs)) enter the cell cycle faster and form bigger myotubes when cultured in vitro, compared to control SCs isolated from uninjured contralateral muscle. Injury-experienced SCs were characterised by the activation of the mTORC 1 signalling pathway, suggesting they are poised to activate sooner following a second injury. Consequently, upon second injury, SCs accumulate in greater numbers in muscle at 3 and 10 days after injury. These changes in SC phenotype and behaviour were associated with accelerated muscle regeneration, as evidenced by an earlier appearance of bigger fibers and increased number of myonuclei per fiber at day 10 after the second injury.
Conclusions
Overall, we show that skeletal muscle injury has a lasting effect on SC function priming them to respond faster to a subsequent injury. The ieSCs have long-term enhanced regenerative properties that contribute to accelerated regeneration following a secondary challenge.
Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria basin, Kenya: study protocol for a cluster-randomized controlled trial
Authors: Kagaya Wataru , Chan Chim Wai , Kongere James , Kanoi Bernard N , Ngara Mtakai , Omondi Protus , Osborne Asley , Barbieri Laura , Kc Achyut , Minakawa Noboru , Gitaka Jesse , Kaneko Akira 
Published: May 2023

Abstract
Background
In the Lake Victoria basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.
Methods
A cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1,315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm.
Discussion
Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria endemic counties and be incorporated as part of Kenya's national malaria elimination strategy.
Trial registration
UMIN000045079, registered on 4th August 2021.