bluuebunny/crossref_metadata_2025_split huggingface dataset:
A conceptual replication of an implicit test of grammatical gender effects on inanimate concepts
Authors: Mahajan Devyani , Durgin Frank H. 
Published: January 2025

Abstract
It has been argued that the incidental and arbitrary use of gender markings for inanimate concepts in language may affect the conceptualization or semantics of those inanimate concepts. The present article sought to replicate the findings of a classic paper that made this argument. Konishi used the potency dimension of the semantic differential method as an implicit measure of perceived gender. He reported that words for inanimate concepts of masculine grammatical gender were rated as higher in potency than words for the same concepts that had feminine grammatical gender. Two preregistered replication studies are reported here. The first was a conceptual replication of Konishi’s study that was conducted with 240 bilingual native speakers of either German or Spanish. Included in the study was a follow-up with 120 monolingual native English speakers. This data was used to test whether the grammatical gender in the native languages of German and Spanish speakers affected their sense of the potency of common inanimate categories when tested in a second language (English) in which they were fluent and the nouns had no grammatical gender. A second version of the study was conducted in the native languages of Spanish and German speakers, as a closer attempt at a replication of Konishi’s original study. The results of both studies provided evidence against the grammatical-gender hypothesis. Bayesian tests of both studies strongly favored the null hypothesis that there were no grammatical gender effects on implicit measures of perceived potency.
Death on “live broadcast”—fish mortichnia from the Upper Cretaceous plattenkalk of Lebanon
Authors: Pokorný Richard , Nohra Roy , Abi Saad Pierre , Vallon Lothar H. 
Published: January 2025

Abstract
Proper identification of behavioral patterns is an important prerequisite for the identification of any trace fossil and even more so for its interpretation. For the last 70 yr, the continually advancing state of ichnological knowledge has led to a gradual recognition of recurrent patterns of organismal behavior documented in the fossil record, which in turn gave rise to the ethological categories. “Mortichnia” was proposed for traces created during a death struggle of the tracemaker but has been reported only in a few cases. Fish mortichnia so far have only been reported in one specimen recovered from the Upper Jurassic Plattenkalk of Nusplingen (SW Germany). The category mortichnia is refined herein, but remains ambiguous. Eight newly discovered unique specimens of mortichnia from Upper Cretaceous marine sediments in central Lebanon (Haqil, En Nammoura) are preserved together with their tracemakers and described herein. In addition, 14 further incomplete specimens were collected where no tracemakers are present. However, morphology and close provenance allow them to be assigned to the same ichnotaxon.
The Lebanese mortichnia originate from fish that were subjected to significant environmental or individual stress leading to their deaths. During death convulsions, their bodies created sedimentary structures with a specific recurring morphology. The ichnogenus Pinnichnus n. igen. with ichnospecies P. haqilensis and P. emmae n. ispp. is proposed for these specimens.
Sinistroporomonorchis bolini n. sp. (Trematoda: Monorchiidae) from the Ocellated killifish, Floridichthys polyommus (Cyprinodontidae) in the Yucatán Peninsula, Mexico based on an integrative taxonomy analysis
Authors: Andrade-Gómez Leopoldo , Espínola-Novelo Juan F. , Solórzano-García Brenda , Pérez-Ponce de León Gerardo 
Published: January 2025

Abstract
Members of Sinistroporomonorchis Wee, Cutmore, Pérez-del-Olmo & Cribb, 2020 represent a small group of trematodes belonging to the Monorchiidae Odhner, 1911 with 5 species described from mugilid hosts. Specimens consistent with the generic concept of Sinistroporomonorchis were obtained from Floridichthys polyommus (Cyprinodontidae); most of them were juveniles from 4 localities within the Yucatán Peninsula. After a detailed morphological examination including scanning electron microscopy images and a principal component analysis, the specimens collected represented a new species, Sinistroporomonorchis bolini n. sp. The new species can be differentiated by the presence of an overall large pharynx including the proportion of pharynx width to oral sucker width, a uterus arranged in 2 main lateral fields, and by presenting robust caeca. In addition, sequences of the 28S of large subunit of nuclear ribosomal RNA and cox1 of the mitochondrial DNA were obtained. Phylogenetic trees inferred from each dataset, placed all the specimens in a monophyletic clade, confirming that the isolates belonged to the same species. The new species is the sixth described for the genus Sinistroporomonorchis, the fifth described from the Yucatán Peninsula and the first described from a non-mugilid host.
How Much Does Suffering Matter?
Authors: Kious Brent M. 
Published: January 2025

Abstract
Ethicists frequently suppose that suffering has special moral significance. It is often claimed that a main goal of medicine—perhaps its primary goal—is the alleviation of human suffering. Following Eric Cassell and others, this essay considers suffering understood as the experience of distress—negative emotions—in response to threats to something that one cares about. It examines whether, on this value-based account of suffering, we should accept the claim that suffering has special moral significance. It argues that we should not: suffering does not add significantly to the value of other human interests and rarely changes our moral obligations itself; it merely seems to have strong moral relevance because it often attends to interests that matter. This is because negative emotions themselves have only limited moral significance, which is due to the fact that their primary mental role is to indicate to us the relative importance of non-emotional goods.
Assessment of psychometric properties of the Persian version of the spiritual care competency self-assessment tool
Authors: Jalali Amir , Merati Fashi Fatemeh , Karami Mohammad , Kalhory Parnia , Mardani Taghvostani Nazanin , Moradi Khalil 
Published: January 2025

Abstract

Background
Spiritual care is essential for the health and well-being of patients and their families, so nursing and midwifery students should have professional competency in this field.

Objectives
The present study aimed to translate the Spiritual Care Competency Self-Assessment Tool for nursing and midwifery students into Persian and evaluate its psychometric properties.

Methods
This study has a methodological study design.

Methods measures
The present study was conducted from July 4 to November 19, 2023, at the Faculty of Nursing and Midwifery in west of Iran. The tool was translated into Persian using the forward-backward translation method. The construct validity was examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) with a total of 536 nursing and midwifery students. The internal consistency was assessed using Cronbach’s alpha coefficient. Also, the reliability of the tool was evaluated using the test–retest method. SPSS version 26 and Lisrel version 8 software were used in this study.

Results
Face and content validity was confirmed quantitatively and qualitatively. The results of EFA and CFA confirmed the tool with 4 factors and 28 items. CFA results indicated a well-fitting model (comparative fit index [CFI] = .97, Non-Normed Fit Index (NNFI) = .92, goodness of fit index [GFI] = .91, root mean square error of approximation [RMSEA] = .05, Standardized Root Mean Square Residual (SRMR) = .046). Pearson’s correlation coefficient confirmed a significant relationship between items, subscales, and the main scale. Also, Cronbach’s alpha coefficient (.968) and test–retest (.867) confirmed the reliability of the Persian version of the tool.

Conclusion
The present study showed that the Persian version of the EPICC Spiritual Care, with 4 factors and 28 items, was suitable for validation and that its psychometric properties were acceptable according to COSMIN criteria. In general, the results showed that the Persian version of the EPICC Spiritual Care is a valid and reliable tool that students, preceptors, and educators can use in clinical settings as a practical way of discussing and evaluating spiritual care competency in Iran.
Cosmology of belonging: The role of community in the therapeutic use of psychedelics
Authors: Dorsen Caroline , Noero Lola , Knapp Michelle , Arden Kristin , Rosa William E 
Published: January 2025

Abstract

Background
The recent wave of clinical trials of psychedelic substances among patients with life-limiting illness has largely focused on individual healing. This most often translates to a single patient receiving an intervention with researchers guiding them. As social isolation and lack of connection are major drivers of current mental health crises and group work is expected to be an important aspect of psychedelic assisted psychotherapy, it is essential that we understand the role of community in psychedelic healing.

Objectives
To explore how psychedelic guides in the United States discuss the role of “community” in naturalistic psychedelic groups.

Methods
This is a secondary qualitative data study of data from a larger modified ethnographic study of psychedelic plant medicine use in the US. Fifteen facilitators of naturalistic psychedelic groups were recruited via snowball sampling. Content analysis was used to identify themes.

Results
Participants viewed the concept of community as essential to every aspect of psychedelic work, from the motivation to use psychedelics, to the psychedelic dosing experience and the integration of lessons learned during psychedelic experiences into everyday life. Themes and subthemes were identified. Theme 1: The arc of healing through community (Subthemes: Community as intention, the group psychedelic journey experience, community and integration); Theme 2: Naturally occurring psychedelic communities as group therapy (Subthemes [as described in Table 2]: Belonging, authenticity, corrective experience, trust, touch).

Significance
Results suggest that existing knowledge about therapeutic group processes may be helpful in structuring and optimizing group psychedelic work. More research is needed on how to leverage the benefit of community connection in the therapeutic psychedelic context, including size and composition of groups, selection and dosing of psychedelic substances in group settings, facilitator training, and role of community integration. Psychedelic groups may provide benefits that individual work does not support.
Temperature Anomalies During Late Boreal Winters With and Without Sudden Stratospheric Warming
Authors: Vokhmyanin Mikhail , Asikainen Timo , Salminen Antti , Mursula Kalevi 
Published: January 2025

AbstractThe polar stratosphere in the Northern Hemisphere influences wintertime surface weather across Northern Eurasia, Eastern Canada, the Middle East, and the Eastern United States. This influence is pronounced following sudden stratospheric warmings (SSWs), during which the polar vortex is displaced from the pole or collapses. The surface impacts vary considerably and are challenging to predict. Here, we study the extratropical surface temperature anomalies in winters with and without SSW. Our analysis reveals a statistically significant surface impact of SSWs is observed in February and March, particularly when the Quasi‐Biennial Oscillation (QBO) is in the easterly phase. During the westerly QBO phases, the SSW surface impact is less systematic. Surface anomalies in winters without SSW are also more pronounced in the late phase of eQBO winters. We further demonstrate that seasonal forecasts of SSW probability can be used to predict regional temperature anomalies especially in Northern Europe.
Storm‐Time Ring Current Plasma Pressure Prediction Based on the Multi‐Output Convolutional Neural Network Model
Authors: Yan Yun , Xie Zi‐Kang , Yue Chao , Zhao Jiu‐Tong , Yang Fan , Xie Lun , Zong Qiu‐Gang , Zhou Xu‐Zhi , Wang Shan 
Published: January 2025

AbstractThe terrestrial ring current consists of particles with energy from several keV to 100 s of keV, and its enhancement will result in magnetic field depression, known as geomagnetic storms. The ring current is mainly composed of H+, O+, He+, and electrons, and there has been a longstanding debate regarding their relative contributions. In this study, we employed a multi‐output convolutional neural network to predict the storm‐time ring current plasma pressures of these particles. Taking solar wind parameters, interplanetary magnetic field (IMF) data, and geomagnetic indices with a time history of 3 days as input parameters, the model shows good performances for electron plasma pressure, H+ plasma pressure, He+ plasma pressure, and O+ plasma pressure in both quiet‐time and storm‐time periods, with high correlation coefficients and small root mean square errors between the measured and the predicted values. Our model successfully captures ring current enhancement during the storm main phase and species‐dependent decay during the recovery phase. Moreover, the model's ability to predict plasma pressures of different species simultaneously facilitates a comparative analysis of their respective contributions to the ring current. The storm event where our model was applied demonstrates that during the storm, the contribution of H+ decreases but still dominates, while the contribution of O+ increases dramatically, and electrons and He+ also play roles in some localized regions. The application of this model is in line with previous observations and simulations, which can be utilized for quantitative analysis of storm‐time ring current dynamics.
GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147
Authors: You Yu , Huo Konglin , He Liang , Wang Tongyue , Zhao Lei , Li Rong , Cheng Xiaoqing , Ma Xuebin , Yue Zhiying , Siwko Stefan , Wang Ning , Liao Lujian , Liu Mingyao , Luo Jian 
Published: January 2025

Abstract
Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro. Mechanistically, GnIH/Gpr147 inhibits osteoclastogenesis by the PI3K/AKT, MAPK, NF-κB and Nfatc1 signaling pathways. Furthermore, GnIH treatment was able to alleviate bone loss in aging, ovariectomy (OVX) or LPS-induced mice. Moreover, the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss. In humans, serum GnIH increases and bone resorption markers decrease after green light exposure. Therefore, our study elucidates that GnIH plays an important role in maintaining bone homeostasis via modulating osteoclast differentiation and demonstrates the potential of GnIH therapy or green light therapy in preventing osteoporosis.
TRAF2 and RIPK1 redundantly mediate classical NFκB signaling by TNFR1 and CD95-type death receptors
Authors: Wagner Jennifer , Vredevoogd David , Yu Xin , Lu Dong , Peeper Daniel S. , Hermanns Heike M. , Wang Jin , Wajant Harald , Siegmund Daniela 
Published: January 2025

Abstract
This study suggests a modified model of TNFR1-induced complex I-mediated NFκB signaling. Evaluation of a panel of five tumor cell lines (HCT116-PIK3CAmut, SK-MEL-23, HeLa-RIPK3, HT29, D10) with TRAF2 knockout revealed in two cell lines (HT29, HeLa-RIPK3) a sensitizing effect for death receptor-induced necroptosis and in one cell line (D10) a mild sensitization for TNFR1-induced apoptosis. TRAF2 deficiency inhibited death receptor-induced classical NFκB-mediated production of IL-8 only in a subset of cell lines and only partly. TRAF5, furthermore, failed to improve DR-induced NFκB signaling in HCT116-PIK3CAmut and HCT116-PIK3CAmut-TRAF2KO cells. These findings argue for a non-obligatory role of TRAF2 in death receptor-induced classical NFκB signaling. Similar as in TRAF2-deficient cells, TNF- and CD95L-induced NFκB signaling was found to be only poorly affected in RIPK1KO cells and in cells treated with the RIPK1-specific PROTAC LD4172. Intriguingly, however, death receptor-induced NFκB signaling was completely inhibited in HCT116-PIK3CAmut cells double deficient for TRAF2 and RIPK1 and in TRAF2-deficient cells treated with LD4172. Moreover, with exception of recruitment of TRADD, acting upstream to TRAF2 and parallel to RIPK1, TNFR1 signaling complex formation was abrogated in TRAF2-RIPK1 DKO cells. Based on our findings, two distinguishable types of TNFR1-interacting complexes promote TNF-induced NFκB signaling: First, a TRADD-TRAF2/cIAP utilizing complex Ia which becomes evident in RIPK1-deficient cells. Second, a non-modified RIPK1 utilizing complex Ib which acts in TRADD- or TRAF2-deficient cells. Complex Ia and Ib may furthermore interact and cooperate to ubiquitinate RIPK1 resulting in a modified complex Ia/b preventing complex Ia and Ib to convert to the established TNFR1-induced cytotoxic complexes IIa and IIb.
Role of the androgen receptor in melanoma aggressiveness
Authors: Di Donato Marzia , Cristiani Costanza Maria , Capone Mariaelena , Garofalo Cinzia , Madonna Gabriele , Passacatini Lucia Carmela , Ottaviano Margaret , Ascierto Paolo Antonio , Auricchio Ferdinando , Carbone Ennio , Migliaccio Antimo , Castoria Gabriella 
Published: January 2025

Abstract
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall survival and long-term disease containment. Nevertheless, the disease often progresses and becomes resistant to the therapies. As such, the discovery of new targets and drugs for advanced melanoma still remains a difficult task. Gender disparities, with a female advantage in melanoma incidence and outcome, have been reported. Although emerging studies support the pro-tumorigenic role of androgen/androgen receptor axis in melanoma, the molecular bases of such evidence are still under intense investigation. We now report that ligand activation of the androgen receptor drives melanoma invasiveness and its escape from natural killer-mediated cytotoxic effect. By combining different experimental approaches, we observe that melanoma escape is mediated by the androgen-triggered shedding of the surface molecule MICA. Specific blockade of ADAM10 or androgen receptor impairs the androgen-induced MICA shedding and melanoma immune-escape. Further, the increase in MICA serum levels correlates with a poor outcome in melanoma patients treated with the anti-PD-1 monoclonal antibody, pembrolizumab. At last, melanoma cells depleted of the androgen receptor become more responsive to the most commonly used immunocheckpoint inhibitors, suggesting that the receptor dampens the immunotherapy efficacy. Taken together, our findings identify the androgen receptor as a diagnostic guidance in melanoma and support the repositioning of AR blockers in clinical management of patients.
Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics
Authors: Wu Honggui , Wang Maoxu , Zheng Yinghui , Xie X. Sunney 
Published: January 2025

Abstract
Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. Here we introduce a high-throughput single-cell Hi-C (dscHi-C) approach and its transcriptome co-assay (dscHi-C-multiome) using droplet microfluidics. Using dscHi-C, we investigate chromatin structural changes during mouse brain aging by profiling 32,777 single cells across three developmental stages (3 months, 12 months, and 23 months), yielding a median of 78,220 unique contacts. Our results show that genes with significant structural changes are enriched in pathways related to metabolic process and morphology change in neurons, and innate immune response in glial cells, highlighting the role of 3D genome organization in physiological brain aging. Furthermore, our multi-omics joint assay, dscHi-C-multiome, enables precise cell type identification in the adult mouse brain and uncovers the intricate relationship between genome architecture and gene expression. Collectively, we developed the sensitive, high-throughput dscHi-C and its multi-omics derivative, dscHi-C-multiome, demonstrating their potential for large-scale cell atlas studies in development and disease.
OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts
Authors: De Rosa Mariarosaria , Barnes Ryan P. , Detwiler Ariana C. , Nyalapatla Prasanth R. , Wipf Peter , Opresko Patricia L. 
Published: January 2025

Abstract
Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine (8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases initiate base excision repair (BER) to remove 8oxoG or prevent mutation. Here, we show OGG1 loss or inhibition, or MUTYH loss, partially rescues telomeric 8oxoG-induced premature senescence and associated proinflammatory responses, while loss of both glycosylases causes a near complete rescue in human fibroblasts. Glycosylase deficiency also suppresses 8oxoG-induced telomere fragility and dysfunction, indicating that downstream single-stranded break (SSB) repair intermediates impair telomere replication. Preventing BER initiation suppresses PARylation and confers resistance to the synergistic effects of PARP inhibitors on 8oxoG-induced senescence. However, OGG1 activity is essential for preserving cell growth after chronic telomeric 8oxoG formation, whereas MUTYH promotes senescence to prevent chromosomal instability from unrepaired damage. Our studies reveal that inefficient completion of 8oxoG BER at telomeres triggers cellular senescence via SSB intermediates which disrupt telomere function.
Taming large-scale genomic analyses via sparsified genomics
Authors: Alser Mohammed , Eudine Julien , Mutlu Onur 
Published: January 2025

Abstract
Searching for similar genomic sequences is an essential and fundamental step in biomedical research. State-of-the-art computational methods performing such comparisons fail to cope with the exponential growth of genomic sequencing data. We introduce the concept of sparsified genomics where we systematically exclude a large number of bases from genomic sequences and enable faster and memory-efficient processing of the sparsified, shorter genomic sequences, while providing comparable accuracy to processing non-sparsified sequences. Sparsified genomics provides benefits to many genomic analyses and has broad applicability. Sparsifying genomic sequences accelerates the state-of-the-art read mapper (minimap2) by 2.57-5.38x, 1.13-2.78x, and 3.52-6.28x using real Illumina, HiFi, and ONT reads, respectively, while providing comparable memory footprint, 2x smaller index size, and more correctly detected variations compared to minimap2. Sparsifying genomic sequences makes containment search through very large genomes and large databases 72.7-75.88x (1.62-1.9x when indexing is preprocessed) faster and 723.3x more storage-efficient than searching through non-sparsified genomic sequences (with CMash and KMC3). Sparsifying genomic sequences enables robust microbiome discovery by providing 54.15-61.88x (1.58-1.71x when indexing is preprocessed) faster and 720x more storage-efficient taxonomic profiling of metagenomic samples over the state-of-the-art tool (Metalign).