bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in affective control covary with changes in mental health difficulties following affective control training (AffeCT) in adolescents
Authors: Schweizer Susanne , Leung Jovita T. , Trender William , Kievit Rogier , Hampshire Adam , Blakemore Sarah-Jayne 
Published: August 2023

AbstractBackgroundEveryday affective fluctuations are more extreme and more frequent in adolescence compared to any other time in development. Successful regulation of these affective experiences is important for good mental health and has been proposed to depend on affective control. The present study examined whether improving affective control through a computerised affective control training app (AffeCT) would benefit adolescent mental health.MethodsOne-hundred and ninety-nine participants (11–19 years) were assigned to complete 2 weeks of AffeCT or placebo training on an app. Affective control (i.e. affective inhibition, affective updating and affective shifting), mental health and emotion regulation were assessed at pre- and post-training. Mental health and emotion regulation were assessed again one month and one year later.ResultsCompared with the placebo group, the AffeCT group showed significantly greater improvements in affective control on the trained measure. AffeCT did not, relative to placebo, lead to better performance on untrained measures of affective control. Pre- to post-training change in affective control covaried with pre- to post-training change in mental health problems in the AffeCT but not the placebo group. These mental health benefits of AffeCT were only observed immediately following training and did not extend to 1 month or year post-training.ConclusionIn conclusion, the study provides preliminary evidence that AffeCT may confer short-term preventative benefits for adolescent mental health.
Treated incidence of first episode psychosis in Sinop, Turkey: results of a 4-year admission-based study – SINOPsy
Authors: Binbay Tolga , Mollaahmetoğlu Özden Merve , Kırlı Umut , Arık Deniz , Alptekin Köksal 
Published: August 2023

AbstractBackgroundThe incidence of psychotic disorders varies in different geographic areas. As there has been no report from Turkey, this study aimed to provide the treated incidence rate of first-episode psychosis (FEP) in a defined area.MethodsAll individuals, aged 15–64 years, presenting with FEP (ICD-10 F20-29, F30-33) to mental health services in a defined catchment-area in Sinop which is located in the Black Sea region of the northern Turkey were recorded over a 4-year period (2009 to 2012). Incidence rates of psychotic disorders and their 95% confidence intervals (CIs) were estimated. Poisson regression was applied to estimate the differences in incidence rate ratio (IRR) by age, sex, and urbanicity.ResultsOne hundred and fifteen FEP participants were identified during the 4 years. Crude incidence rates of all psychoses, schizophrenia, other psychotic disorders, and affective psychotic disorders were respectively 38.5 (95% CI 27.1–49.9), 10.7 (95% CI 6.6–14.8), 10.0 (95% CI 5.7–14.3) and 17.7 (95% CI 11.3–24.2) per 100 000 person-years. After age-sex standardisation the rates increased slightly. There were no gender differences in the incidence rates. IRR of any psychotic disorder was highest in the youngest age group (15–24 years) compared to the oldest age group (55–64 years), 7.9 (95% CI 2.8–30.5). In contrast with previous studies, the incidence rate of any psychotic disorder was not significantly increased in urban areas compared with rural areas.ConclusionsThe current study, the first of its kind from Turkey, indicates that the risk of schizophrenia and other psychotic disorders in a lowly urbanised area of Turkey is comparable to those reported in Western European cities.
Management of Mass-Casualty Incidents in Nepal: A Qualitative Case Study of Three District Hospitals in Nepal
Authors: Singh Prinka , Lamine Hamdi , Sapkota Sujan , Bahattab Awsan , Eriksson Anneli 
Published: August 2023

AbstractIntroduction:The frequency of disasters world-wide has significantly increased in recent years, leading to an increase in the number of mass-casualty incidents (MCIs). These MCIs can overwhelm health care systems, requiring hospitals to respond quickly and effectively, often with limited resources. While numerous studies have identified the challenges in managing MCIs and have emphasized the importance of hospital disaster preparedness, there is a research gap in the preparedness level and response capacities of district hospitals in Nepal.Study Objective:This study attempts to fill this gap by understanding the perception of hospital staff in managing MCIs in district hospitals of Nepal.Methods:A qualitative case study was conducted in three district hospitals in Nepal. Semi-structured interviews were conducted with the hospital personnel, using an interview guide. An inductive thematic analysis was carried out to understand their perception on the most recent MCI management.Results:Three themes emerged from the data analysis: enablers in MCI management, barriers in MCI management, and recommendations for the future. Use of multiple communication channels, mobilization of entire hospital teams, mobilization of police in crowd control, presence of disaster store, and pre-identified triage areas were the major enablers that facilitated successful MCI management. Nonetheless, the study also revealed challenges such as a lack of knowledge on MCI response among new staff, disruptions caused by media and visitors, and challenges in implementing triage.Conclusion:This study emphasized the importance of hospital disaster preparedness in managing MCIs and highlighted the significance of overcoming barriers and utilizing enablers for an efficient response. The findings of this study can provide the basis for the Ministry of Health and Population Nepal and district hospitals to plan initiatives for the effective management of MCIs in the future.
A munshi discussion on religion, and the Simla Akhbār, circa 1850
Authors: Ernst Carl 
Published: August 2023

AbstractAs a case study of the changing mentalities that emerged in colonial India, this article analyses a discussion that took place among several munshis (secretaries trained in Persian to run the affairs of princely states), and also provides a translation and edition of the text. The subject was a short polemical letter refuting the immortality of the soul, published around 1850 in the Simla Akhbār (Simla News). The main question entertained in this correspondence was not the merit of the sceptical argument, based in part on modern medical findings, but the potential public impact of dismissing a religious doctrine that sustains morality. Two of the participants in this conversation, Shivaprasad and Sital Singh, displayed the full range of changes that made the nineteenth century so extraordinary, and the way they responded illustrates some of the salient features and stages of this process, including the difficulty of foreseeing the elimination of much of the system for which munshis were trained.
In situ characterization of tamarind (Tamarindus indica L.) fruit and spotting sweet tamarind types in Palakkad gap of Kerala
Authors: Menon Jalaja S. , Asna A. C. , Menon Meera V. , Pooja A. , Gopinath Pratheesh P. , Singh A. K. 
Published: August 2023

AbstractKerala, a humid tropical southern state, is the third largest producer of Tamarind (Tamarindus indica L.) in India. This tree spice is an important livelihood option for the rural society, especially in Palakkad district which is the lead producer of tamarind in the state with a few accepted primitive cultivars, viz. ‘valanpuli’, ‘madhurapuli’ and ‘thenpuli’. A survey was conducted to identify the fruit variability and document the sweet tamarind types of Palakkad. This study revealed the variability and weight of 30 fruits was seen to be the most indicative variable of tamarind in Kerala. The pod length varied from 5.28 to 23.41 cm and fruit weight from 4.83 to 43.40 g. Hierarchical clustering on principal component analysis resulted in six clusters. The clusters I, IV and V represented collections with fruit weight more than 20 g. Box plot diagrams revealed the high real pulp value in sample KTJ 162 (9.57) and high fruit length in KTJ 44 (21.68 cm). Among 113 collections, 18 samples were collected as perceived sweet types based on local enquiry. In the scatter plot between total soluble solids and ratio between total soluble solids and total titrable acidity, two samples were spotted as sweet types with acidity below 8%. Further molecular characterization and systematic crop improvement programmes are required for conserving the eroding gene pool of tamarind in Kerala and to develop sweet types for commercial production.
Posttraumatische Belastungsstörung infolge eines Suizidversuchs
Authors: Lüke Ronja , Gerlach Alexander L. , Gysin-Maillart Anja , Lewitzka Ute , Teismann Tobias 
Published: August 2023

Zusammenfassung: Hintergrund: Erste Studien legen nahe, dass ein selbstdurchgeführter Suizidversuch überraschend häufig eine PTBS-Symptomatik verursachen könnte. Die berichteten Prävalenzangaben der Studien variieren jedoch erheblich. Methode: In der vorliegenden Online-Studie wurden N = 50 Suizidversuchsüberlebenden zu suizidversuchsbezogenen PTBS-Symptomen und gegenwärtigen Suizidgedanken befragt. Zur Falldefinition diente eine modifizierte Version der Posttraumatischen Checkliste für DSM-5 (PCL-5) entweder auf Basis eines Cut-off Wertes oder auf Syndrom-Basis. Ergebnisse: In Abhängigkeit von der Falldefinition wurden 52 % ( n = 26) bzw. 42 % ( n = 21) der Teilnehmenden als Personen identifiziert, welche potenziell die Diagnosekriterien einer PTBS infolge eines eigenen Suizidversuchs erfüllten. Teilnehmende mit suizidversuchsbezogener PTBS-Symptomatik berichteten teilweise über mehr gegenwärtige Suizidgedanken. Schlussfolgerung: Die Ergebnisse legen nahe, dass Personen nach einem selbstdurchgeführten Suizidversuch eine PTBS-Symptomatik entwickeln. Aufgrund der Relevanz dieser Ergebnisse für eine wirksame Behandlung von Suizidversuchsüberlebenden sind weitere Studien an größeren deutschen Stichproben und unter Nutzung klinischer Interviews zu empfehlen.
Numerical Simulations of Metallic Ion Density Perturbations in Sporadic E Layers Caused by Gravity Waves
Authors: Qiu Lihui , Yamazaki Yosuke , Yu Tao , Becker Erich , Miyoshi Yasunobu , Qi Yifan , Siddiqui Tarique A. , Stolle Claudia , Feng Wuhu , Plane John M. C. , Liang Yu , Liu Huixin 
Published: August 2023

AbstractTidal signatures in sporadic E (Es) layer have been confirmed by observations and simulations. However, the effect of gravity waves (GWs) on the Es layer formation process has not yet been fully understood. In this paper, the modulation of Es layers by GWs is examined through numerical simulations, in which a physics‐based model of Es layer is forced by neutral winds from the High Altitude Mechanistic General Circulation Model that can resolve GWs with horizontal wavelengths longer than 156 km (λh > 156 km). Comparison of the simulation results with and without the GWs (1,350 km > λh > 156 km) forcing reveals that the inclusion of GWs leads to short‐period (1.2–3 hr) density perturbations in Es layers, which are also seen in ground‐based ionosonde observations. At a given time, the metallic ion density at altitudes between 120 and 150 km can either increase (by up to ∼+600%) or reduce (by up to −90%) in response to GW forcing. The relative density perturbations are smaller (by up to 60%) between 90 and 120 km altitude. It is also found that the GW effect on the metallic ion density relates to the longitude, which is mostly explained by the geographical distribution of GWs activity in the mesosphere and lower thermosphere region. The longitudinal variation of the background geomagnetic field plays only a secondary role.
Calibration and Validation for the Surface Biology and Geology (SBG) Mission Concept: Recommendations for a Multi‐Sensor System for Imaging Spectroscopy and Thermal Imagery
Authors: Turpie Kevin R. , Casey Kimberly A. , Crawford Christopher J. , Guild Liane S. , Kieffer Hugh , Lin Guoqing (Gary) , Kokaly Raymond , Shrestha Alok K. , Anderson Cody , Ramaseri Chandra Shankar N. , Green Robert , Hook Simon , Lukashin Constantine , Thome Kurt 
Published: August 2023

AbstractThe primary objective of the National Aeronautics and Space Administration (NASA) Surface Biology and Geology (SBG) mission is to measure biological, physical, chemical, and mineralogical features of the Earth's surface, realizing a key conceptual component of the envisioned NASA Earth System Observatory (ESO). SBG is planned to launch as a two‐platform mission in the late 2020s, the first of the ESO satellites. Targeted science and applications objectives based on observations of the Earth's SBG helped to define the mission architecture and instrument capabilities for the SBG mission concept. These objectives further drove the need for enabling change detection and trending of surface biological and geological features. These needs implied fundamental calibration goals to achieve the necessary science data quality characteristics. To meet those goals, calibration and validation pre‐launch and on‐orbit methods formed a basis of the calibration and validation concept, including the combined use of on‐board references, vicarious techniques, and routine lunar imaging. International collaboration with space agencies in other countries, an important feature of the recommended SBG mission architecture, uncovered and emphasized the need for inter‐calibration techniques that underscored the importance of collaborative instrument characterization data sharing and the use of common calibration references that are International System of Units (SI) traceable in pre‐launch and post‐launch on orbit calibration mission phases. International collaboration through the use of terrestrial and aquatic networks on six continents for vicarious calibration and validation activities will further assure necessary science data quality while in orbit.
Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Authors: Nguyen Thanh T. , Wei Shibo , Nguyen Thu Ha , Jo Yunju , Zhang Yan , Park Wonyoung , Gariani Karim , Oh Chang-Myung , Kim Hyeon Ho , Ha Ki-Tae , Park Kyu Sang , Park Raekil , Lee In-Kyu , Shong Minho , Houtkooper Riekelt H. , Ryu Dongryeol 
Published: August 2023

AbstractMitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse cell death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli and that maintain cellular homeostasis via mitohormesis, the mitochondrial unfolded protein response, and mitophagy. The review also presents details on various forms of mitochondria-associated programmed cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, and paraptosis, and highlights their involvement in age-related disease pathogenesis, collectively suggesting therapeutic directions for further research.
Diversity and complexity of cell death: a historical review
Authors: Park Wonyoung , Wei Shibo , Kim Bo-Sung , Kim Bosung , Bae Sung-Jin , Chae Young Chan , Ryu Dongryeol , Ha Ki-Tae 
Published: August 2023

AbstractDeath is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.
N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
Authors: Yun Rebecca , Hong Eunji , Kim Junil , Park Bora , Kim Staci Jakyong , Lee Bona , Song Yong Sang , Kim Seong-Jin , Park Sujin , Kang Jin Muk 
Published: August 2023

AbstractKIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer. In this study, we report the role of N-linked glycosylation in KIAA1324 as a functional post-translational modification (PTM). Loss of N-linked glycosylation eliminated the potential of KIAA1324 to suppress cancer cell proliferation and migration. Furthermore, we demonstrated that KIAA1324 undergoes fucosylation, a modification of the N-glycan mediated by fucosyltransferase, and inhibition of fucosylation also significantly suppressed KIAA1324-induced cell growth inhibition and apoptosis of gastric cancer cells. In addition, KIAA1324-mediated apoptosis and tumor regression were inhibited by the loss of N-linked glycosylation. RNA sequencing (RNAseq) analysis revealed that genes most relevant to the apoptosis and cell cycle arrest pathways were modulated by KIAA1324 with the N-linked glycosylation, and Gene Regulatory Network (GRN) analysis suggested novel targets of KIAA1324 for anti-tumor effects in the transcription level. The N-linked glycosylation blockade decreased protein stability through rapid proteasomal degradation. The non-glycosylated mutant also showed altered localization and lost apoptotic activity that inhibits the interaction between GRP78 and caspase 7. These data demonstrate that N-linked glycosylation of KIAA1324 is essential for the suppressive role of KIAA1324 protein in gastric cancer progression and indicates that KIAA1324 may have anti-tumor effects by targeting cancer-related genes with N-linked glycosylation. In conclusion, our study suggests the PTM of KIAA1324 including N-linked glycosylation and fucosylation is a necessary factor to consider for cancer prognosis and therapy improvement.
Accurate haplotype construction and detection of selection signatures enabled by high quality pig genome sequences
Authors: Tong Xinkai , Chen Dong , Hu Jianchao , Lin Shiyao , Ling Ziqi , Ai Huashui , Zhang Zhiyan , Huang Lusheng 
Published: August 2023

AbstractHigh-quality whole-genome resequencing in large-scale pig populations with pedigree structure and multiple breeds would enable accurate construction of haplotype and robust selection-signature detection. Here, we sequence 740 pigs, combine with 149 of our previously published resequencing data, retrieve 207 resequencing datasets, and form a panel of worldwide distributed wild boars, aboriginal and highly selected pigs with pedigree structures, amounting to 1096 genomes from 43 breeds. Combining with their haplotype-informative reads and pedigree structure, we accurately construct a panel of 1874 haploid genomes with 41,964,356 genetic variants. We further demonstrate its valuable applications in GWAS by identifying five novel loci for intramuscular fat content, and in genomic selection by increasing the accuracy of estimated breeding value by 36.7%. In evolutionary selection, we detect MUC13 gene under a long-term balancing selection, as well as NPR3 gene under positive selection for pig stature. Our study provides abundant genomic variations for robust selection-signature detection and accurate haplotypes for deciphering complex traits in pigs.
Cryopreservation and revival of Hawaiian stony corals using isochoric vitrification
Authors: Powell-Palm Matthew J. , Henley E. Michael , Consiglio Anthony N. , Lager Claire , Chang Brooke , Perry Riley , Fitzgerald Kendall , Daly Jonathan , Rubinsky Boris , Hagedorn Mary 
Published: August 2023

AbstractCorals are under siege by both local and global threats, creating a worldwide reef crisis. Cryopreservation is an important intervention measure and a vital component of the modern coral conservation toolkit, but preservation techniques are currently limited to sensitive reproductive materials that can only be obtained a few nights per year during spawning. Here, we report the successful cryopreservation and revival of cm-scale coral fragments via mL-scale isochoric vitrification. We demonstrate coral viability at 24 h post-thaw using a calibrated oxygen-uptake respirometry technique, and further show that the method can be applied in a passive, electronics-free configuration. Finally, we detail a complete prototype coral cryopreservation pipeline, which provides a platform for essential next steps in modulating post-thaw stress and initiating long-term growth. These findings pave the way towards an approach that can be rapidly deployed around the world to secure the biological genetic diversity of our vanishing coral reefs.
Click-electrochemistry for the rapid labeling of virus, bacteria and cell surfaces
Authors: Depienne Sébastien , Bouzelha Mohammed , Courtois Emmanuelle , Pavageau Karine , Lalys Pierre-Alban , Marchand Maia , Alvarez-Dorta Dimitri , Nedellec Steven , Marín-Fernández Laura , Grandjean Cyrille , Boujtita Mohammed , Deniaud David , Mével Mathieu , Gouin Sébastien G. 
Published: August 2023

AbstractMethods for direct covalent ligation of microorganism surfaces remain poorly reported, and mostly based on metabolic engineering for bacteria and cells functionalization. While effective, a faster method avoiding the bio-incorporation step would be highly complementary. Here, we used N-methylluminol (NML), a fully tyrosine-selective protein anchoring group after one-electron oxidation, to label the surface of viruses, living bacteria and cells. The functionalization was performed electrochemically and in situ by applying an electric potential to aqueous buffered solutions of tagged NML containing the viruses, bacteria or cells. The broad applicability of the click-electrochemistry method was explored on recombinant adeno-associated viruses (rAAV2), Escherichia coli (Gram-) and Staphyloccocus epidermidis (Gram + ) bacterial strains, and HEK293 and HeLa eukaryotic cell lines. Surface electro-conjugation was achieved in minutes to yield functionalized rAAV2 that conserved both structural integrity and infectivity properties, and living bacteria and cell lines that were still alive and able to divide.