bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macroalgal-derived alginate/wastepaper hydrogel to alleviate sunflower drought stress
Authors: Gomaa Mohamed , Aldaby Eman S. E. 
Published: May 2023

Abstract
Main conclusion
Alginate/wastepaper hydrogel mitigated sunflower drought stress by increasing the water holding capacity of the soil and decreasing phosphate leaching. The hydrogel promoted sunflower growth and decreased stress related biomarkers.

Abstract
There is a growing interest in the development of biodegradable hydrogels for the alleviation of drought stress on plants. A novel hydrogel based on brown algal-derived alginate and wastepaper was developed and tested as a soil supplement for sunflower growth under moderate (75% field capacity (FC)) and extreme (50% FC) water-deficit stress. The hydrogel showed fast swelling in water, which obeyed the pseudo-first order kinetics. Besides, it increased the water holding capacity of the soil and exhibited a good phosphate adsorption (37 mg PO4− g−1 hydrogel after 6 days) in the soil, and more than 67% of the adsorbed phosphate was desorbed after 20 days. Thus, the phosphate leaching from the hydrogel-amended soil in a column experiment was only 2.77 mg after 4 times of over-irrigation, compared to 11.91 mg without the hydrogel. The hydrogel application promoted various root traits such as fresh and dry biomass, area, and length by > 2-, > 1.6-, > 1.35-, and > 1.3-folds under both water regimes in relation to the no-hydrogel treatments at the same conditions. Furthermore, the sunflower shoots exhibited similar proline contents to the well-watered control (100% FC), with > 50% reduction in relation to the drought-stressed plants under the same conditions. Similarly, the malondialdehyde contents were lowered by > 15%. The analysis of the antioxidant enzymes also indicated a marked reduction in the specific activities of catalase and ascorbate peroxidase under both 75 and 50% FC compared to the respective controls. Additionally, the hydrogel promoted the uptake of phosphate by sunflower roots. These results implied that the developed biodegradable hydrogel could be effectively applied as a soil additive to alleviate drought stress on crops.
Round-Robin test for the histological diagnosis of acute colonic Graft-versus-Host disease validating established histological criteria and grading systems
Authors: Hippe Katrin , Kreft Andreas , Reu-Hofer Simone , Rosenwald Andreas , Ferrazzi Fulvia , Daniel Christoph , Amann Kerstin , Kraus Sabrina , Holler Ernst , Kandulski Arne , Hirsch Daniela , Buttner Anke , Rösler Wolf , Hildner Kai , Winkler Julia , Büttner-Herold Maike 
Published: May 2023

AbstractHistomorpholgy is one of the mainstays of acute Graft-versus-host disease (GvHD) diagnosis. However, concerns about reproducibility and the most appropriate grading system question its usefulness. Our aim was to assess histomorphological parameters and previously reported grading systems for GvHD regarding reproducibility and validity. Moreover, we propose that sum scores, derived by combining separately scored morphological parameters into a total score, might provide a simplified but equally effective means to grade GvHD. A total of 123 colon biopsies were assessed across four pathologists for intestinal GvHD using a Round-Robin test and results were correlated with clinical findings. Interobserver reproducibility was high for histological parameters that were evaluated as indicators of acute GvHD. Published grading systems were moderately reproducible (ICC 0.679–0.769) while simplified sum scores, in comparison, showed better interrater reliability (ICC 0.818–0.896). All grading systems and sum scores were associated with clinical signs of GvHD and in part with therapy response and survival. However, they were not able to stratify patients according to the clinical severity of GvHD. In a hot-spot analysis 1 crypt apoptotic body (CAB) in 10 crypts was a reasonable cut-off value for minimal diagnostic criteria of GvHD. In conclusion, histology can contribute to the diagnosis of GvHD and is reproducible. Published grading systems are able to reflect clinical findings as are simplified sum scores, which showed improved reproducibility and might be easier to handle as they are based on adding up histological parameters rather than transferring histological findings into a separate grading system. Sum scores will have to be further tested in a prospective setting.
Prevention of radiation-induced liver toxicity after interstitial HDR brachytherapy by pentoxifylline and ursodeoxycholic acid: patient compliance and outcome in a randomized trial
Authors: Damm Robert , Wybranska Joanna , Hass Peter , Walke Mathias , Omari Jazan , Pech Maciej , Seidensticker Ricarda , Ricke Jens , Seidensticker Max 
Published: May 2023

Abstract
Aim
To investigate the impact of pentoxifylline (PTX, 3 × 400 mg per day) and ursodeoxycholic acid (UDCA, 3 × 250 mg per day) administered for 12 weeks on radiation-induced liver toxicity.

Materials and methods
Inclusion criteria were liver metastases of extrahepatic malignancies undergoing HDR-BT. 36 patients were prospectively randomized to the
medication (N = 18) or control arm (N = 18) and follow-up by hepatobiliary magnetic resonance imaging (MRI) was scheduled 6 and 12 weeks after local ablation by HDR-BT. We determined the threshold doses of fRILI by image fusion of MRI with the dosimetry data.

Results
32 patients completed the study schedule. Per-protocol treatment was limited to 8 patients in the medication group and 16 patients in the control group. 22 adverse events of any grade likely or certainly related to PTX were recorded in 12 patients leading to the discontinuation of the study medication in 7 patients and to a dose reduction of PTX in 2 patients. In the per-protocol population, statistical analysis failed to prove a reduction of fRILI 6 and 12 weeks after HDR-BT. The incidence of adverse effects attributed to PTX (70.6%) was well above the data found in the literature for its approved indication.

Conclusion
The study endpoint was not met mainly attributed to the low statistical power of the small per-protocol cohort. Independently, PTX cannot be recommended for the reduction of radiation-induced liver toxicity in oncologic patients undergoing HDR-BT of liver metastases. Further studies might focus on a combination of UDCA with other potential drugs to help establish a preventive and tolerable regimen.
Semi-reduced order stochastic finite element methods for solving contact problems with uncertainties
Authors: Zheng Zhibao , Nackenhorst Udo 
Published: May 2023

AbstractThis paper develops two-step methods for solving contact problems with uncertainties. In the first step, we propose stochastic Lagrangian multiplier/penalty methods to compute a set of reduced basis. In the stochastic Lagrangian multiplier method, the stochastic solution is represented as a sum of products of a set of random variables and deterministic vectors. In the stochastic penalty method, the problem is divided into the solutions of non-contact and possible contact nodes, which are represented as sums of the products of two different sets of random variables and deterministic vectors, respectively. The original problems are then transformed into deterministic finite element equations and one-dimensional (corresponding to stochastic Lagrangian multiplier method)/two-dimensional (corresponding to stochastic penalty method) stochastic algebraic equations. The deterministic finite element equations are solved by existing numerical techniques, and the one-/two-dimensional stochastic algebraic equations are solved by a sampling method. Since the computational cost for solving stochastic algebraic equations does not increase dramatically as the stochastic dimension increases, the proposed methods avoid the curse of dimensionality in high-dimensional problems. Based on the reduced basis, we propose semi-reduced order Lagrangian multiplier/penalty equations with two components in the second step. One component is a reduced order equation obtained by smooth solutions of the reduced basis and the other is the full order equation for the nonsmooth solutions. A significant amount of computational cost is saved since the sizes of the semi-reduced order equations are usually small. Numerical examples of up to 100 dimensions demonstrate the good performance of the proposed methods.
Lexicon-based probabilistic indexing of handwritten text images
Authors: Vidal Enrique , Toselli Alejandro H. , Puigcerver Joan 
Published: May 2023

AbstractKeyword Spotting (KWS) is here considered as a basic technology for Probabilistic Indexing (PrIx) of large collections of handwritten text images to allow fast textual access to the contents of these collections. Under this perspective, a probabilistic framework for lexicon-based KWS in text images is presented. The presentation aims at providing formal insights which help understanding classical statements of KWS (from which PrIx borrows fundamental concepts), as well as the relative challenges entailed by these statements. The development of the proposed framework makes it clear that word recognition or classification implicitly or explicitly underlies any formulation of KWS. Moreover, it suggests that the same statistical models and training methods successfully used for handwriting text recognition can advantageously be used also for PrIx, even though PrIx does not generally require or rely on any kind of previously produced image transcripts. Experiments carried out using these approaches support the consistency and the general interest of the proposed framework. Results on three datasets traditionally used for KWS benchmarking are significantly better than those previously published for these datasets. In addition, good results are also reported on two new, larger handwritten text image datasets (Bentham and Plantas), showing the great potential of the methods proposed in this paper for indexing and textual search in large collections of untranscribed handwritten documents. Specifically, we achieved the following Average Precision values: IAMDB: 0.89, George Washington: 0.91, Parzival: 0.95, Bentham: 0.91 and Plantas: 0.92.
Niche differentiation of Mucoromycotinian and Glomeromycotinian arbuscular mycorrhizal fungi along a 2-million-year soil chronosequence
Authors: Mansfield Thomas M. , Albornoz Felipe E. , Ryan Megan H. , Bending Gary D. , Standish Rachel J. 
Published: May 2023

AbstractCurrent literature suggests ecological niche differentiation between co-occurring Mucoromycotinian arbuscular mycorrhizal fungi (M-AMF) and Glomeromycotinian AMF (G-AMF), but experimental evidence is limited. We investigated the influence of soil age, water availability (wet and dry), and plant species (native Microlaena stipoides and exotic Trifolium subterraneum) on anatomical root colonisation and DNA profiles of M-AMF and G-AMF under glasshouse conditions. We grew seedlings of each species in soils collected from the four stages of a soil chronosequence, where pH decreases from the youngest to oldest stages, and phosphorus (P) is low in the youngest and oldest, but high in the intermediate stages. We scored the percentage of root length colonised and used DNA metabarcoding to profile fungal richness and community composition associated with treatment combinations. Soil age, water availability, and plant species were important influencers of root colonisation, although no M-AMF were visible following staining of M. stipoides roots. Soil age and host plant influenced fungal richness and community composition. However, response to soil age, potential host species, and water availability differed between M-AMF and G-AMF. Root colonisation of T. subterraneum by M-AMF and G-AMF was inversely correlated with soil P level. Community composition of M-AMF and G-AMF was structured by soil age and, to a lesser extent, plant species. Richness of M-AMF and G-AMF was negatively, and positively, correlated with available P, respectively. These findings are experimental evidence of ecological niche differentiation of M-AMF and G-AMF and invite further exploration into interactive effects of abiotic and biotic factors on their communities along successional trajectories.
The mechanical loading of the spine in physical activities
Authors: Schäfer Robin , Trompeter Katharina , Fett Daniela , Heinrich Kai , Funken Johannes , Willwacher Steffen , Brüggemann Gert-Peter , Platen Petra 
Published: May 2023

Abstract
Purpose
To summarize the mechanical loading of the spine in different activities of daily living and sports.

Methods
Since the direct measurement is not feasible in sports activities, a mathematical model was applied to quantify spinal loading of more than 600 physical tasks in more than 200 athletes from several sports disciplines. The outcome is compression and torque (normalized to body weight/mass) at L4/L5.

Results
The data demonstrate high compressive forces on the lumbar spine in sport-related activities, which are much higher than forces reported in normal daily activities and work tasks. Especially ballistic jumping and landing skills yield high estimated compression at L4/L5 of more than ten times body weight. Jumping, landing, heavy lifting and weight training in sports demonstrate compression forces significantly higher than guideline recommendations for working tasks.

Conclusion
These results may help to identify acute and long-term risks of low back pain and, thus, may guide the development of preventive interventions for low back pain or injury in athletes.
Sequence and phylogenetic analysis of a novel alphaendornavirus, the first virus described from the oomycete plant pathogen Phytophthora heveae
Authors: Raco Milica , Jung Thomas , Horta Jung Marilia , Chi Nguyen Minh , Botella Leticia , Suzuki Nobuhiro 
Published: May 2023

AbstractHere, we report the discovery and complete genome sequence of a novel virus, designated as “Phytophthora heveae alphaendornavirus 1” (PhAEV1), from a single isolate of the plant pathogenic oomycete Phytophthora heveae (kingdom Stramenipila) isolated from a tropical evergreen lowland rainforest in northern Vietnam. PhAEV1 was detected by both cellulose affinity chromatography of dsRNA and high-throughput sequencing of total RNA, and its presence and sequence were confirmed by RT-PCR and Sanger sequencing. The PhAEV1 genome, 12,820 nucleotides (nt) in length, was predicted to encode a single large polyprotein with the catalytic core domain of viral (superfamily 1) RNA helicase (HEL, amino acid [aa] positions 1,287-1,531), glycosyltransferase (GT, aa positions ca. 2,800-3,125), and RNA-directed RNA polymerase (RdRp, aa positions 3,875-4,112). PhAEV1 is the most similar to Phytophthora cactorum alphaendornavirus 3, sharing 39.4% and 39.1% nt and aa sequence identity, respectively. In addition to the first 5′-terminal AUG codon, three additional in-frame methionine codons were found in close proximity (nt 14-16, 96-98, and 176-178), suggesting potential additional translation initiation sites. Conserved RdRp motifs (A-E) similar to those detected in related endornaviruses were identified in PhAEV1, as well as in several previously described alphaendornaviruses from other Phytophthora species in which these motifs had not been identified previously. Phylogenetic analysis showed that PhAEV1 clusters with members of the genus Alphaendornavirus in the family Endornaviridae and is basal to two other alphaendornaviruses described from another oomycete, Phytophthora cactorum. PhAEV1 is the first virus reported in P. heveae.
Dentoskeletal features and growth pattern in Beckwith-Wiedemann spectrum: is surgical tongue reduction always necessary?
Authors: Defabianis Patrizia , Ninivaggi Rossella , Romano Federica 
Published: May 2023

Abstract
Objectives
The role of tongue reduction surgery (TRS) in preventing excessive mandibular growth and anterior open bite in children with Beckwith–Wiedemann Spectrum (BWSp) is still controversial. This cross-sectional study aimed at comparing craniofacial growth pattern in children affected by BWSp either treated or not treated with early TRS for severe macroglossia. Considering the invasive nature of such surgery, the present study could help in clarifying the need for TRS to reduce or prevent growth disturbances.

Materials and methods
Orthopantomography and lateral skull x-ray images were taken either from surgically treated or non-surgically treated patients, aged 5 to 8 years, to compare dentoskeletal features and craniofacial growth by cephalometric analysis. Molecular testing results were collected from their medical records.

Results
Eighteen BWSp patients were consecutively recruited: 8 underwent TRS at 14.9 ± 2.2 months of age, while 10 did not. Anterior open bite and dental class III were more frequently observed in the surgically treated group, but none showed skeletal class III. No statistically significant differences were observed in growth pattern, but children treated with TRS showed a tendency towards both maxillary and mandibular prognathism with protruding lower lip. Growth pattern seemed to be not related to molecular subtypes.

Conclusions
These preliminary data suggest that early TSR does not improve craniofacial growth pattern and dentoskeletal features in BWSp children.

Clinical relevance
Reductive glossectomy may not be justified for preventing or avoiding oro-facial deformities in BWSp; therefore, early monitoring of maxillofacial development of each affected child has a great clinical significance.
Effect of apical root resection, orthodontic extrusion, and surgical crown lengthening on load capability
Authors: Naumann M. , Adali U. , Rosentritt M. , Happe A. , Frankenberger R. , Sterzenbach G. 
Published: May 2023

Abstract
Objectives
This study aims to investigate the load-to-fracture of procedures changing crown-to-root ratio (RCRR) aimed to restore severely damaged upper central incisors to avoid tooth extraction compared to implant placement. There is no evidence on load capability after apical root resection (AR), orthodontic extrusion (OE), and surgical crown lengthening (SCL) in respect to RCRR, respectively.

Material and methods
Human maxillary central incisors were endodontically treated, decoronated, and divided into 4 groups (n = 48). The following specimen preparation was performed: (I) adhesive core-and-post build-up (control), (II) as (I) and 2 mm apical root resection (AR), (III) before adhesive core-and-post build-up teeth were shortened 2 mm coronally (OE) (IV) as (I), but specimens were embedded 4 mm instead of 2 mm below the CEJ (SCL), group (V) implant-borne restoration with individual all-ceramic abutments (n = 12; ∅4.1/l = 12 mm) (IBR). All specimens received all-ceramic crowns, thermo-mechanical (TML), and subsequent linear loading (LL) until failure. RCRR were calculated and log-rank, Kruskal–Wallis, Mann–Whitney U, ANOVA, and chi-square tests applied (p = 0.05).

Results
Fracture loads after subsequent LL differed significantly (p = 0.001) between groups, while implants showed the highest values. Fmax median (min/max) were as follows: (I) 252 (204/542), (II) 293 (243/443), (III) 253 (183/371), (IV) 195 (140/274), and (V) 446 (370/539). Pair-wise comparison showed significant differences (p = 0.001) between group I/IV and group V, I, and IV (p = 0.045), II and IV (p = 0.001), and III compared to IV (p = 0.033), respectively. RCRR below 1 significantly increased load capability compared to RCRR = 1.

Conclusions
OE appears to preferably ensure biomechanical stability of teeth that are endodontically treated and receive core-and-post and crown placement compared to SCL. AR has no adverse biomechanical impact. RCRR < 1 is biomechanically beneficial.

Clinical relevance
For endodontically treated and restored teeth, orthodontic extrusion should be preferred compared to surgical crown lengthening prior single-crown restoration. As orthodontic extrusion, apical root resection has no adverse effect on load capability. Single-crown implant-borne restorations are most load capable.
Differential outcomes of outpatient only versus combined inpatient/outpatient treatment in early intervention for adolescent borderline personality disorder
Authors: Cavelti Marialuisa , Seiffert Nora , Lerch Stefan , Koenig Julian , Reichl Corinna , Kaess Michael 
Published: May 2023

AbstractClinical guidelines for adults with borderline personality disorder (BPD) recommend outpatient psychotherapy as first-line treatment. Little is known whether this recommendation is also applicable to adolescents. The current study examined the relationship between treatment setting and the outcome of early intervention for adolescents with BPD pathology. One-hundred and seventy-eight adolescents from a specialized outpatient clinic were assessed at baseline, and at 1- and 2-year follow-up. Sixty-three participants who received inpatient treatment during the first year were assigned to the “combined inpatient/outpatient group”, 115 participants to the “outpatient only group”. Generalized linear and mixed models with inverted probability weights to adjust for baseline differences were applied to examine the impact of group on clinical changes over time. Both groups demonstrated a significant decrease in BPD features, depressive symptoms, psychopathological distress, non-suicidal self-injury (NSSI), suicidal thoughts, suicide attempts, and overall illness severity, and a significant increase in quality of life and psychosocial functioning from baseline to follow-up 2. The decrease in NSSI and overall illness severity, and the increase in psychosocial functioning from baseline to follow-up 1 were greater in the outpatient only group, with comparable improvements between groups from follow-up 1 to follow-up 2. Both outpatient treatment and combined outpatient/inpatient treatment resulted in clinical improvements over time, with some indication for faster changes in the outpatient only setting. The findings provide preliminary evidence that the recommendation of outpatient psychotherapy as the first-line treatment for BPD also holds true for adolescents.
DETEXA: declarative extensible text exploration and analysis through SQL
Authors: Foufoulas Yannis , Zacharia Eleni , Dimitropoulos Harry , Manola Natalia , Ioannidis Yannis 
Published: May 2023

AbstractMetadata enrichment through text mining techniques is becoming one of the most significant tasks in digital libraries. Due to the exponential increase of open access publications, several new challenges have emerged. Raw data are usually big, unstructured, and come from heterogeneous data sources. In this paper, we introduce a text analysis framework implemented in extended SQL that exploits the scalability characteristics of modern database management systems. The purpose of this framework is to provide the opportunity to build performant end-to-end text mining pipelines which include data harvesting, cleaning, processing, and text analysis at once. SQL is selected due to its declarative nature which offers fast experimentation and the ability to build APIs so that domain experts can edit text mining workflows via easy-to-use graphical interfaces. Our experimental analysis demonstrates that the proposed framework is very effective and achieves significant speedup, up to three times faster, in common use cases compared to other popular approaches.