bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Nanoparticle Encapsulation and Encoding on the Surface Chemistry of Polymer Carrier Beads
Authors: Scholtz Lena , Tavernaro Isabella , Eckert J. Gerrit , Lutowski Marc , Geißler Daniel , Hertwig Andreas , Hidde Gundula , Bigall Nadja , Resch-Genger Ute 
Published: April 2023

Abstract
Surface-functionalized polymer beads encoded with molecular luminophores and nanocrystalline emitters such as semiconductor nanocrystals, often referred to as quantum dots (QDs), or magnetic nanoparticles are broadly used in the life sciences as reporters and carrier beads. Many of these applications require a profound knowledge of the chemical nature and total number of their surface functional groups (FGs), that control bead charge, colloidal stability, hydrophobicity, and the interaction with the environment and biological systems. For bioanalytical applications, also the number of groups accessible for the subsequent functionalization with, e.g., biomolecules or targeting ligands is relevant. In this study, we explore the influence of QD encoding on the amount of carboxylic acid (COOH) surface FGs of 2 µm polystyrene microparticles (PSMPs), loaded with luminescent core/shell CdSe QDs by QD addition during bead formation by a thermally induced polymerization reaction and a post synthetic swelling procedure. Quantification of the accessible number of COOH groups on the surface of QD-encoded and pristine beads was performed by two colorimetric assays, utilizing differently sized reporters and electrostatic and covalent interactions, and compared to the total number of FGs obtained by a conductometric titration and Fourier transform infrared spectroscopy (FTIR). In addition, a comparison of the impact of QD and dye encoding on the bead surface chemistry was done. Our results demonstrate the influence of QD encoding and the QD-encoding strategy on the number of surface FG that is ascribed to an interaction of the QDs with the carboxylic acid groups on the bead surface. These findings are of considerable relevance for applications of nanoparticle-encoded beads and safe-by-design concepts for nanomaterials.
How prepared are health systems in low- and middle-income countries to provide rehabilitation in conflict and disaster response? A scoping review
Authors: Gosling Justine , Maritz Roxanne , Laplante-Lévesque Ariane , Sabariego Carla 
Published: April 2023

Abstract

IntroductionConflict and other disasters such as earthquakes or landslides result in traumatic injuries creating surges in rehabilitation and assistive technology needs, exacerbating pre-existing unmet needs. Disasters frequently occur in countries where existing rehabilitation services are underdeveloped, hindering response to rehabilitation demand surge events.AimsThe primary aim of this scoping review was to synthesize the evidence on the preparedness of health systems in low- and middle-income countries to respond with rehabilitation services and assistive technology to the demand associated with conflict and disaster situations. A secondary aim was to summarize related recommendations identified in the gathered literature.MethodologyA scoping review was conducted using the Arksey and O’Malley framework to guide the methodological development. The results are reported in accordance with PRISMA-ScR. Four bibliographic databases were used: CINHAL, Cochrane, Pubmed, Scopus and. Key international organisations were also contacted. The search range was 2010–2022. Eligible publications were categorized for analysis under the six World Health Organization health systems buildings blocks.ResultsOf the 27 studies included in the scoping review, 14 focused on service delivery, 6 on health workforce, 4 on health information systems and 3 on the leadership and governance building block. No study focused on financing nor assistive technology. This review collected the most frequently referenced recommendations for actions that should be taken to develop rehabilitation services in disasters. The most prominent recommendations were; the provision early and multi-professional rehabilitation, including the provision of assistive technology and psychological support, integrated community services; disaster response specific training for rehabilitation professionals; advocacy efforts to create awareness of the importance of rehabilitation in disasters; and the integration of rehabilitation into disaster preparedness and response.Conclusion:The literature demonstrates that rehabilitation is poorly integrated into health systems disaster preparedness and response in low- and middle-income countries, largely due to low awareness of rehabilitation, undeveloped rehabilitation health systems and a lack of rehabilitation professionals, and disaster specific training for them. The paucity of evidence available hinders advocacy efforts for rehabilitation in disaster settings and limits the sharing of experiences and lessons learnt to improve rehabilitation preparedness and response. Advocacy efforts need to be expanded.
Characterization of spray dried cellulose nanofibrils produced by disk refining process at different fineness levels
Authors: Hwang Sungjun , Walker Colleen C. , Ozcan Soydan , Tekinalp Halil , Han Yousoo , Gardner Douglas J. 
Published: April 2023

Abstract
Three types of wood pulp feedstocks were disk refined to produce cellulose nanofibrils at different fineness levels ranging from 50 to 100%, and the resulting aqueous suspensions of cellulose nanofibrils were spray dried. The spray drying experiments were carried out to examine different processing conditions for the different CNF feedstock types and fines level at various suspension concentrations to produce dry samples with free-flowing powder morphologies. The fineness levels and solids contents of CNF suspensions were set to 80% or more and 1.8% or less, respectively. If the solids content of the CNF solutions was high and the fibrillation level was low, plugging was experienced in the spray head because of the high viscosity of the suspensions, resulting in production of poor-quality powders. In terms of energy savings, even if the CNF suspension solids content was increased to 1.5 wt.%, the powder quality and the production yields were excellent. It was confirmed that high-quality powder under 20 µm were produced at a 90% fibrillation level of all CNF feedstocks. The resulting dry CNF powders were characterized to determine particle size distributions and morphological properties via a scanning electron microscope and a laser diffraction particle size analyzer. The particle sizes were smaller at higher fibrillation levels and lower solids content of the CNF suspensions. CNF suspension derived from bleached kraft pulp, the average particle size decreased by 43% and 33% with the lowered solids contents from 1.8–1%, and the increased fineness levels from 80–100%, respectively.
The Effect of Cocoa Butter Substitute (CBS) Produced from Palm Kernel Oil and Virgin Coconut Oil (VCO) on The Quality of Milk Chocolate
Authors: Sabahannur St , Alimuddin Suraedah , Subaedah St , Wahdaniya Nurul , Faharuddin Firda Yunita 
Published: April 2023

Abstract

Consumption of chocolate products in the tropics is increasing. The chocolate manufacturing industry cannot rely solely on cocoa butter (CB), because cocoa butter is relatively expensive and has a low melting point, making it less suitable for the tropics. To meet the demand for chocolate, it is necessary to substitute vegetable fat which can increase the melting point and good proximate value. In the chocolate industry, vegetable fats are used which have physical properties similar to cocoa butter, known as Cocoa Butter Substitute (CBS) and virgin coconut oil (VCO). This study shows an increase in the melting point of milk chocolate substituted for CBS and VCO compared to using only cocoa butter. In addition, there was an increase in the content of carbohydrates, proteins, fats, and also the levels of lauric acid and oleic acid in milk chocolate.
The Impact of Glioblastoma on Patients' Cognitive and Demographic Characteristics and Psychological Well-Being of Patients and Caregivers: A Single-Center Retrospective Study
Authors: Günerhan Göksal , Öcal Özgür , Dağlar Zeynep , Çağıl Emin , Ertuğrul Yavuz , Belen Ahmet Deniz 
Published: April 2023

Abstract
Background
The objective of this retrospective study was to investigate the prognostic factors, patients' characteristics, and outcomes of adult patients with glioblastoma and to evaluate the impact of the disease on the mental health and emotional well-being of patients and their relatives.
Materials and Methods
The study included 98 adult patients with glioblastoma who underwent pre- and post-operative cognitive assessments using the Mini-Mental State Examination (MMSE). The Hospital Anxiety and Depression Scale (HADS) was also used to evaluate and compare psychological symptoms of patients and their relatives over time. Seizures were seen in 45,9% of patients, and the mean age of the patients was 60,1 ± 13,8 years. The patients were evaluated at various time intervals before and after surgery, and the data were analyzed retrospectively.
Results
The study found that before surgery, the anxiety levels of caregivers were significantly higher than those of patients during all evaluation periods. Additionally, the depression scores of caregivers were significantly higher than those of patients only in the first month following the operation. There were no significant differences in depression scores between patients and caregivers in the other assessment intervals. The average cognitive level of patients, as assessed by the MMSE scale, was 22,4 before the operation and 20,91 after the operation.
Conclusion
Glioblastoma has a significant impact on the mental health and emotional well-being of both patients and their relatives. The study highlights the importance of providing early support to both patients and their relatives before surgery. The study's strength is that it focuses on an early time point, prior to surgery, where both patients and their relatives are already affected and may require additional support. The results of this study can help healthcare professionals to better understand the psychological impact of glioblastoma and provide more targeted support to patients and their caregivers.
LINC00665 contributes to cholangiocarcinoma progression by modulating IRF1/PD-L1
Authors: Huang Peng , Liu Yang , Zhou Yongxu , Yin Wenxin , Yu Liang , Xu Yi , Kang Pengcheng , Cui Yunfu 
Published: April 2023

Abstract
Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in human cancers. However, the underlying biological functions and mechanisms of lncRNAs in cholangiocarcinoma (CCA) remain unclear. Here, we found that LINC00665 expression was increased in CCA tumour samples and that LINC00665 expression was p negatively correlated with survival rate in CCA patients. Our observations showed that LINC00665 promoted the proliferation, migration and invasion of CCA cells in vitro and in vivo. In addition, we found that LINC00665 interacts with IRF1 and increases IRF1 protein levels. LINC00665 promotes tumour progression phenotypes in part by regulating IRF1. In addition, LINC000665 can increase the expression of PD-L1 and promote tumour immune escape. These results suggest that LINC00665 is an oncogene and that the inhibition of LINC00665 expression may be a new therapeutic target for cholangiocarcinoma.
Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: Development and evaluation of a new nomogram
Authors: Zheng Xiaoxia , Ye Jiangnan , Zhan Qunzhang , Zhao Weifeng , Liao Zhongqin , Ye Xiaolin , Qu Chongzheng 
Published: April 2023

Abstract
Objective:
To construct a new prediction nomogram to predict the risk of musculoskeletal pain in patients with primary osteoporosis who receive zoledronic acid intravenously for the first time.
Method:
Clinical data of 368 patients with primary osteoporosis who received the first intravenous injection of zoledronic acid in our hospital from December 2019 to December 2022 were studied. Patients were divided into a musculoskeletal pain group (n =258) and a non-musculoskeletal pain group (n =110) based on the presence or absence of musculoskeletal pain 3 days after injection. Statistically significant predictors were screened by logistic regression analysis and the minimum absolute contraction and selection operator (LASSO) to construct a nomogram. The nomogram was evaluated by the receiver operating characteristic (ROC) curve, the calibration curve, the C-index, and the decision curve analysis (DCA) and verified in a validation cohort.
Results:
The independent predictors of the nomogram were age, serum 25-hydroxyvitamin D, NSAIDs, vitamin D, and BMI. The area under the ROC curve (AUC) was 0.980 (95% CI, 0.915–0.987), showing excellent predictive performance. The nomogram c index was 0.980, and the nomogram c index for internal verification remained high at 0.979. Moreover, calibration curves show that the nomogram has good consistency. Finally, the DCA showed that the net benefit of the nomogram was 0.20-0.49.
Conclusion:
Establish an accurate and reliable nomogram for musculoskeletal pain after the first intravenous administration of zoledronic acid. Clinicians must pay attention to the evaluation and prevention of adverse reactions after zoledronic acid injection in order to increase patients' willingness to receive a second dose of zoledronic acid.
Construction of blow-up solution for 5-dimensional critical Fujita type equation with different blow-up speed
Authors: Zhao Jianfeng , Zhang Liqun 
Published: April 2023

Abstract
We are concerned with blow-up solutions of the 5-dimensional energy critical heat equation $u_t=\Delta u + | u |^{\frac{4}{3}}u$. Our main result is to show that the existence of type II solutions blows up at any k points with arbitrary k blow-up rates. The inner-outer gluing method has been employed.
Highly effective flame retarded TPU introduced by a new phosphorus-containing Schiff base derivative at low addition
Authors: Hao Fenghao , Zhang Jian , Xu Xueling , Deng Yaxin , Chen Yajun , Li Mengqi , Hu Jing , Qian Lijun 
Published: April 2023

Abstract
A highly effective novel phosphorus-containing Schiff base derivative flame retardant N,N′-bis[1-(salicylidene) methanephenylphosphonic acid]-1,2- ethylene diamine (SMAE) was successfully synthesized via the addition reaction between phenyl hypophosphite and N, N'-bis(salicylidene)ethylenediamine. It had great thermal stability (T5%, 271℃) and char forming ability (29.6 wt % at 700 °C), which was added to TPU at different additions to improve the flame retardant performance. Results showed that only 4% SMAE increased the limiting oxygen index value of TPU from 22.3% to 32%, passing UL 94 V-0 rating. Meanwhile, the peak heat release rate, average heat release rate and total heat release of TPU also decreased by 3%, 19% and 16%, respectively. The constituent and microscopic morphology of the residual char of TPU samples were observed by fourier transform infrared spectroscopy and scanning electron microscopy (SEM), which indicated SMAE produced phosphinic acid to promote the formation of a more complete and dense char layer for TPU. The pyrolysis gas phase products were recorded by thermogravimetric Fourier transform infrared spectroscopy (TG-FTIR). The results showed that SMAE could produced PO· terminated the chain reaction and released inert gases (carbon dioxide and ammonia) to dilute combustible gases during combustion. Therefore, SMAE endows TPU with excellent flame retardancy.
Web accessibility Evaluation of private and government websites for people with Disabilities through Fuzzy Classifier in USA
Authors: Simhadri Naga , K Chaitanya 
Published: April 2023

Abstract
The impact of technological advancements in construct the web in order tomake it accessible for people with impairments was examined through a retrospective analysis of websites. For the years 1997-2002, anarbitraryillustration of overall webpages and a suitabilityillustration of US administration webpages were researched and related. The accessing the web becomes barrier (WAB) and difficulty ratings remained computed. ANOVA and Tukey's HSD remainedrecycled to detect alterations between centuries for overallpositions. ANOVA repeat measurements wereutilized to analyze changes in US government websites, and Pearson's connection factor (r) was calculated toward assess the connection among convenience and difficulty. Arbitrary webpages gradually develop unreachable as difficulty rises. The complexity of US government websites is increasing while they are still accessible through fuzzy classifier. It's not necessary for increasing complexity, which is frequently brought on by adding complicated components to a Web page, to result in greater accessibility hurdles reducing the use of scripts in webpage design will increase complexity.
The application of Compont gel for sublay mesh fixation in subcostal hernia repair: a retrospective study
Authors: Liang Chen , Zheng Ruotong , Xing Xiaowei , Chen Jie , Chen Fuqiang 
Published: April 2023

Abstract
Background
Subcostal hernia is a type of lateral abdominal wall hernia that usually occurs after open hepatobiliary and esophagogastric operations. The composition of different myofascial layers makes the anatomic reconstruction of the abdominal wall difficult. We aim to evaluate the use of medical glue in fixing the mesh during subcostal hernioplasty compared to sutures.
Methods
From Jan 2016 to Dec 2021, the data of 58 patients who underwent sublay mesh techniques for subcostal hernioplasty were retrospectively analyzed. The patients were divided into two groups. In the glue group, a combination of a titanium-coated mesh and Compont gel were applied in 12 patients for mesh fixation; In the suture group, a standard polypropylene mesh or composite mesh was fixed by sutures in 14 patients. The operation features, and peri- and postoperative outcomes were analyzed statistically. Meanwhile, medical costs were calculated and evaluated.
Results
No difference between the two groups was observed concerning demographic characteristics, and operation features such as defect size, and mesh size used for operation. In the follow-up period, there was no difference between the two groups for recurrences, or other complications, such as chronic pain, foreign body sensation, infection of the abdominal wall, and seroma. During hospitalization, the operation time was significantly shortened in the glue group (78.9 ± 20.4 minutes vs 100.8 ± 37.5 minutes, P = 0.043), while the medical costs are comparable between the two groups (P > 0.05).
Conclusion
The use of Compont gel in fixing the mesh during subcostal hernia repair is associated with a shortened operation time and is convenient, safe, and effective. They are worthy of clinical application.
Initial Experience of 10 Imaging Vendors With the IHE SHARAZONE: a New Distributed Peer to Peer Test Service for DICOM Objects
Authors: Nichols Steven , Laffin Bruno , Parisot Charles 
Published: April 2023

Abstract
The cross-vendor exchange of DICOM (Digital Imaging and Communications in Medicine) images and objects has been identified as a crucial factor in improving the robustness of product interoperability in the healthcare industry. This, in turn, accelerates innovation and advances the field of medical imaging. Despite multiple attempts to establish a sustainable model for the sharing of DICOM samples, the industry has yet to see a successful implementation. To address this issue, Integrating the Healthcare Enterprise (IHE) has created the IHE SHARAZONE, a continuous cross-vendor DICOM data sharing test service. IHE is a well-respected organization in the healthcare industry, known for its ability to turn standards such as DICOM, HL7 V2, HL7 CDA and HL7 FHIR into practical, real-world solutions for clinical practice. The IHE SHARAZONE aims to provide a solution for the need for a reliable and consistent cross-vendor DICOM data sharing system. In order to evaluate the effectiveness of the IHE SHARAZONE, a five-month pilot was conducted with ten imaging vendors. The pilot concluded with a participant survey, the results of which are reported in this publication. The findings of the survey provide valuable insights into the initial experience with the IHE SHARAZONE, and can inform future improvements and developments to this important service. The healthcare industry is constantly evolving, and it is essential that medical imaging technology keeps pace with these advancements. The IHE SHARAZONE provides a crucial step towards achieving this goal, by enabling cross-vendor exchange of DICOM images and objects, and improving the robustness of product interoperability. This, in turn, will accelerate innovation and advance the field of medical imaging, ultimately leading to better patient outcomes.
Overweight and obesity determined by body mass index criteria for Asian populations adversely affect assisted reproductive outcomes among Chinese women with polycystic ovary syndrome
Authors: Ye Yinghui , Zhao Ruimin , Yang Xinyun , Cui Long , Wang Lefeng 
Published: April 2023

Abstract
Background: Obesity is a common feature in women with polycystic ovary syndrome (PCOS) and associated with multiple adverse reproductive outcomes. However, the impact of overweight and obesity on reproductive outcome of PCOS women underwent the in vitro fertilization-embryo transfer (IVF-ET) is currently controversial. Since appropriate body mass index (BMI) levels differ across ethnic groups, this study was performed to investigate the effects of BMI on IVF outcomes among women with PCOS using BMI cut-off values proposed by the World Health Organization for Asian populations.
﻿Method(s): This was a retrospective study including 1066 women with PCOS receiving IVF treatment at our institution between January 2018 and June 2021, among whom 960 underwent their first fresh or frozen embryo transfer. Participants were categorized according to their BMI as follows: patients with normal weight (BMI < 23 kg/m2), patients with overweight (BMI: 23–24.9 kg/m2), and patients with obesity (BMI ≥ 25 kg/m2). The effect of BMI on IVF outcomes (the numbers of oocytes, two pronuclear zygotes, and good-quality embryos; the rates of implantation, miscarriage, clinical pregnancy and live birth) was evaluated by descriptive statistics and logistic regression models with confounders adjusted.
Interventions: no
Result(s): High BMI was associated with significantly lower numbers of total oocytes retrieved, mature oocytes, two pronuclear zygotes, and good-quality embryos among women with PCOS. PCOS patients with a BMI ≥ 23 kg/m2 had significantly lower live birth rates (41.9% vs. 49.1%; adjusted odds ratio [aOR], 0.75; ﻿95% confidence interval [CI], 0.57–0.97) and implantation rates (35.8% vs. 43.9%; aOR, 0.76; 95% CI, 0.61–0.93) than those with normal BMI.
Conclusion(s): PCOS patients with a BMI ≥ 23 kg/m2 have lower live birth rates than those with a BMI < 23 kg/m2. Defining obesity and overweight with ethnicity-specific BMI cut-offs may help to improve IVF outcomes among PCOS patients.