bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effect of Buyang Huanwu Decoction on Cerebral Ischemia/Reperfusion Injury by Inhibiting Autophagy Based on AMPK/UlK1 Signaling Pathway
Authors: Zhang Ruijuan , Zhao Yanmeng , Ma Xiujuan , Ye Jiabei , Shan Yudong , Yu Wentao , Zhou Xiaohong , Gao Weijuan 
Published: February 2023

The aim of the paper is to explore whether AMPK/UlK1 signaling pathway is involved in regulating autophagy and alleviating cerebral ischemia/reperfusion (I/R) injury. On this basis, study the regulatory effect of Buyang Huanwu Decoction (BHD) on AMPK/UlK1 signaling pathway, aiming to clarify the molecular mechanism of BHD in alleviating cerebral I/R injury and the protective effect of BHD containing serum (BHDS) on OGD/R neurons. The research group adopted the following methods: Neurons cultured for 7 days in vitro were randomly divided into normal control group, model group (OGD/R), AMPK activator (AICAR) group (3 mmol/L), Buyang Huanwu Decoction medicated serum (BHDS) group (3%), Buyang Huanwu Decoction medicated serum + AMPK activator (BHDS + AICAR) group. The protein expressions of p-AMPK, AMPK, p-UlK1, UlK1, Beclin-1 and LC3B in neurons were detected by Western blot, the fluorescence intensity and apoptosis rate of neuron autophagosome CYTO-ID staining were detected by flow cytometry, the fluorescence intensity and morphological changes of neuron LC3B were detected by immunofluorescence double labeling method, the morphological changes of neurons were observed by inverted microscope, and the survival rate of neurons was detected by CCK-8 method. Neuron OGD/R model and the optimal concentration of BHDS. The neurons in the model group were subjected to hypoxia and glucose deprivation for 1 h, 2 h, 3 h, 4 h and reoxygenation and glucose deprivation for 24 h. The survival rate of neurons and the release rate of l DH to determine whether the model was successfully established. And the results show that BHDS group, the survival rate of OGD/R neurons was significantly increased, and the apoptosis rate was significantly decreased. Among them, 3% BHDS intervention at the same time of hypoxia glucose deprivation for 3 h and reoxygenation glucose for 24 h was the best condition. In BHDS group, the levels of p-AMPK/AMPK, p-UlK1/UlK1, beclin-1, CYTO-ID and LC3B fluorescence intensity, and the transformation from LC3B-Ⅰ to LC3B-Ⅱ of OGD/R neurons were significantly decreased. So we can draw a conclusion that BHD can inhibit autophagy and alleviate cerebral I/R injury through AMPK/UlK1 signaling pathway.
Development and Quality of Higher Education in Transnational Cooperation: Some Cases from China, Japan, Malaysia
Authors: Chen Mengyu 
Published: February 2023

The theme of this thesis is to discuss the emergence of the transnational collaborative higher education (TNHE) model in the context of the internationalisation of higher education. A secondary qualitative research and literature review approach were used for the study, which focused on China, Japan and Malaysia. The literature review involved understanding the reasons why TNHE was able to emerge in these countries and the development of transnational collaborative higher education institutions (THEI) in these countries. In addition to this, attention is paid to the governance, quality and some of the challenges of inequality in these countries in TNHE. From the extensive literature obtained, we learn that China is opening up to enhance its higher education; Japan, traumatised by the economic crisis, is trying to recover its position by relying on transnational cooperation; and Malaysia is striving to internationalise higher education and pursue a high-quality higher education system. In addition, the paper analyses the monitoring and quality assurance issues of TNHE and the need for governments or institutions in different regions to take into account local educational development, culture, regional development and resource mix. More importantly, where the value of postcooperation eucation will be focused and whether they have the capacity and systems to face these challenges.
Analisis Faktor yang Mempengaruhi Purchase Behavior (Studi Pada Wanita Muslim Kota Batam)
Authors: Putra Edy Yulianto , Firdaus Nydia Salsabila 
Published: February 2023

ABSTRACT This research was conducted to identify factors influencing buying habits toward hijab fashion among Muslim women in Batam City. The object of this study is Muslim women respondents who like to use and buy hijab fashion in Batam City. The independent variables used are Religiosity, Subjective Norm, Brand Knowledge, Perceived Usefulness, Brand Trust, and Attitude as intervening variables, and Purchase Behavior as the dependent variable. This study uses an explanatory method with a quantitative approach with a purposive sampling technique. The data analysis that the author uses is smart PLS. The study results show that five factors influence the habit of buying hijab fashion continuously, with attitudes/behavior as mediationABSTRAKPenelitian ini dilakukan dengan tujuan untuk menganalisis dan mengidentifikasi faktor apa saja yang mempengaruhi kebiasaan membeli terhadap hijab fashion dikalangan wanita Muslim Kota Batam. Objek pada kajian ini adalah responden wanita Muslim yang gemar menggunakan dan membeli hijab fashion di Kota Batam. Variabel independent yang digunakan adalah Religiosity, Subjective Norm, Brand Knowledge, Perceived Usefulness, Brand Trust serta Attitude sebagai variabel intervening dan Purchase Behavior sebagai variabel dependen. Kajian ini menggunakan metode eksplanatori dengan pendekatan kuantitatif dengan Teknik purposive sampling. Analisa data yang penulis gunakan adalah dengan menggunakan smart PLS. Hasil penelitian menunjukkan bahwa terdapat 5 faktor yang mempengaruhi kebiasaan membeli hijab fashion terus menerus dengan sikap/perilaku sebagai mediasi
To the question of the clinical predictive value of the sFlt-1:PlGF ratio is related to the placental dysfunction
Authors: Pylypenko A.V. , Medved V.I. 
Published: February 2023

The objective: to evaluate the clinical and prognostic value and meaning of the ratio of the anti-angiogenic factor of soluble fms-like tyrosine kinase-1 (sFlt-1) to the angiogenic factor of the placental growth factor (PlGF) in the dynamics of pregnancy as markers of various variants of placental dysfunction. Materials and methods. A retrospective cohort study of 40 pregnant women, who were distributed by gestation term (up to 34 weeks and after 34 weeks) and the level of sFlt-1:PlGF ratio (<38 is low level, > 110 – high level) was performed. The statistical comparison of the sFlt-1:PlGF ratio with the development of hypertensive disorders during pregnancy and fetal growth retardation (FGR), as well as the duration of the period from research to childbirth was calculated. Results. Preeclampsia (PE) developed in 12 persons out of 40 pregnant women. The sFlt-1:PlGF ratio in the period till 27 weeks of pregnancy in groups of women with PE and without it does not differ with a statistically significant level (p=0.3). In other gestation terms the sFlt-1:PlGF ratio in women with and without placental dysfunction is statistically significant (p<0.05). The sFlt-1:PlGF ratio >38 increases the risk of PE more than 4 times (RR = 4.6) and is statistically significant in a period till 34 weeks [95 % CI: 1.4-14,9]. After 34 weeks of pregnancy the sFlt-1:PlGF ratio >110 has a higher sensitivity (Se=0.75).An analysis of the sFlt-1:PlGF ratio for the purpose of FGR predicting, both in combination with hypertensive disorders during pregnancy or without them, demonstrated its high importance during pregnancy up to 34 weeks (p=0.001). A strong reverse correlation (ƿ= -0.7) was found between the value of the sFlt-1:PlGF ratio and the number of days from the date of research till childbirth at the level of significance of 0.0001 in pregnant women up to 34 weeks. Conclusions. The predictive value of the conventional method of assessing the preeclampsia (PE) risk and the preventive efficiency of acetylsalicylic acid is low. In the absence of clinical manifestation of PE the determination of the sFlt-1:PlGF ratio for a predication till 27 weeks of pregnancy is not informative, so it is not recommended. If the sFlt-1:PlGF ratio is > 38 in the period till 34 weeks, the relative risk is 4.6 [95 % CI: 1.4–14.9]. If the level of the sFlt-1:PlGF ratio is high at first investigation there is no sense to repeat the research in dynamics. In the case of low the sFlt-1:PlGF ratio for a reasonable suspicion of PE development, repeated research can help make an adequate clinical decision. The determination of the sFlt-1:PlGF ratio for a predication or confirmation of fetal growth retardation till 34 weeks is clinically reasonable and informative. There is a strong reverse correlation between the sFlt-1:PlGF ratio and the number of days before the current birth.
Women have clinical aspects of infertility with thyroid pathology
Authors: Beraya D.Yu. 
Published: February 2023

The objective: to study the main clinical aspects of infertility in women with various variants of thyroid pathology.Materials and methods. A clinical screening examination of 496 women with infertility (main group), of which 238 were diagnosed the various thyroid pathologies, and 80 women with thyroid pathology without reproductive function disorders (control group) was carried out.Results. Primary infertility was diagnosed in 49.4 % of examined women, and secondary infertility – in 50.6 % of patients. Female infertility was diagnosed in 327 (65.9 %) patients, male infertility in 126 (25.4 %) women; infertility of unknown genesis was established during the examination of 43 married couples (8.7 %). In the structure of the causes of female infertility, the tubal-peritoneal factor prevailed (37 %), the frequency of external genital endometriosis was 36.4 %, the endocrine factor – 23.2 %, and the uterine factor – 3.4 %. A combination of infertility factors was determined in 23.8 % of women. The results of studying the reproductive history showed that 251 patients with secondary infertility have a history of 279 pregnancies. The positive obstetrical outcomes such as term uncomplicated childbirth was established only in 48 (19.1 %) patients; the first term birth occurred in 28 (11.1 %) women, the second birth – in 16 (6.4 %) patients. Pregnancy ended with premature birth in 27 (10.7 %) women, induced abortions – in 41 (16.3 %), spontaneous abortions – in 58 (23.1 %), 41of them (16.3 %) had one spontaneous abortion; missed abortion – in 57 (22.7 %) patients, ectopic pregnancy – in 19.1 %.A comparative evaluation of thyroid screening results in infertile and fertile women demonstrated that the prevalence of thyroid pathology in infertile patients was 3.8 times higher compared to fertile women (48 % and 12.5 %, respectively). In the structure of the thyroid gland pathology in both groups the presence of antibodies to thyroperoxidase combined with echo signs of autoimmune thyroiditis prevailed, which is 2.8 times more often diagnosed in the group of infertile women compared to fertile women (24 % and 8.7 %, respectively).Conclusions. The prevalence of thyroid pathology in patients with infertility is 3.8 times higher compared to fertile women. In women with secondary infertility pregnancy loss in the I trimester of gestation is dominated in the structure of reproductive outcomes.
PENERAPAN PENDEKATAN SAINTIFIK DALAM PEMBELAJARAN ONLINE PADA MATA PELAJARAN IPS SISWA KEAS VII DI SMP NEGRI 4 SAMARINDA
Authors: Faradilla Mega , Sudarman Sudarman , Subagio Nasib 
Published: February 2023

Tujuan penelitian ini untuk mengetahui tujuan dan proses pelaksanaan Penerapan Model saintifik dalam pembelajaran online siswa pada mata pelajaran IPS di kelas VII siswa SMP Negeri 4 Samarinda. Jenis penelitian yang digunakan adalah kualititaf deskriptif. Alat dan teknik pengumpulan data yang digunakan yakni observasi,wawancara,dan dokumentasi. Sedangkan untuk analisis data yang dikumpulkan dari teknik observasi,wawancaea, dn dokumentasi dikelompokan dan diorganisasikan, untuk menjawab fokus penelitian. Hasil penelitian menunjukan bahwa: (1) perencanaan pembelajaran dengan menggunakan pendekatan saintifik dalam pembelajaran online pada mata pelajaran IPS kelas VII di SMP Negeri 4 Samarinda sudah memenuhi kaidah saintifik, (2) proses pelaksanan denga menggunakan penekatan saintifik dalam pembelajaran online pada mata pelajaran IPS kelas VII di SMP Negeri 4 Samarinda sudah memenuhi kaidah saintifik.
HUBUNGAN MOTIVASI BELAJAR DENGAN HASIL BELAJAR PADA MATA PELAJARAN EKONOMI DI SMA NEGERI 3 SAMARINDA
Authors: Dewi Putri Nila Sari , Sudarman Sudarman , Haidar Kadori 
Published: February 2023

Tujuan penelitian ini untuk mengetahui motivasi belajar, untuk mengetahui hasil belajar, dan untuk mengetahui signifikansi hubungan antara motivasi belajar dan hasil belajar. Jenis penelitian yang digunakan adalah jenis penelitian kuantitatif. Responden penelitian ini adalah siswa kelas XI IPS di SMA Negeri 3 Samarinda yang berjumlah 90 orang. Hasil penelitian menunjukan bahwa: (1) rata-rata/mean hasil belajar motivasi belajar siswa kelas XI IPS SMA Negeri 3 Samarinda adalah 58,82, atau dalam kategori sedang dan (2) rata-rata/mean hasil belajar siswa kelas XI IPS SMA Negeri 3 Samarinda adalah 81,03 atau dalam kategori sedang. Teknik pengumpulan data dalam penelitian ini adalah teknik observasi, dokumentasi, wawancara dan angket. Berdasarkan hasil analisis data yang dilakukan dapat diketahui nilai thitung = 0,210 > ttabel 0,046, maka secara parsial ada hubungan signifikan antara motivasi belajar dengan hasil belajar pada mata pelajaran ekonomi di SMA Negeri 3 Samarinda.
PENGARUH LITERASI KEUANGAN DAN GAYA HIDUP TERHADAP PERILAKU KONSUMTIF MAHASISWA PADA PRODI PENDIDIKAN EKONOMI FKIP UNIVERSITAS MULAWARMAN
Authors: Hartiningsih Murni , Reza Reza , Rahayu Vitria Puri 
Published: February 2023

Peneliti ingin meneliti tentang pengetahuan keuangan di Mahasiswa Program Studi Pendidikan Ekonomi FKIP Universitas Mulawarman Angkatan 2018-2019 karena sudah mengetahui mengenai perencanaan keuangan, simpan pinjam, asuransi, dan investasi setelah mendapatkan matakuliah manajemen keuangan. Masalah keuangan muncul karena ada pengelolaan keuangan yang tidak baik, gaya hidup dan pola konsumsi yang boros. Tujuan dari penelitian ini adalah ingin melihat apakah ada hubungan dari literasi keuangan dan gaya hidup terhadap perilaku konsumtif mahasiswa pada Prodi Pendidikan Ekonomi FKIP Universitas Mulawarman Angkatan 2018-2019.
Penelitian ini menggunakan metode kuantitatif dengan populasi penelitian adalah mahasiswa Pendidikan Ekonomi Universitas Mulawarman Angkatan 2018-2019. Penelitian melakukan pengumpulan data dengan membagikan kuesioner dengan pengukuran skala likert dan wawancara dengan mahasiswa Pendidikan Ekonomi Universitas Mulawarman Angkatan 2018-2019. Hasil penelitian ini adalah (1) literasi keuangan mempunyai pengaruh yang signifikan terhadap perilaku konsumtif pada mahasiswa Pendidikan Ekonomi Universitas Mulawarman. (2) Gaya hidup mempunyai pengaruh yang signifikan terhadap perilaku konsumtif pada mahasiswa Pendidikan Ekonomi Universitas Mulawarman. (3) Pengaruh literasi keuangan dan gaya hidup stimultan mempunyai pengaruh terhadap perilaku konsumtif pada Mahasiswa Pendidikan Ekonomi Universitas Mulawarman.
PENGARUH DUKUNGAN ORANG TUA TERHADAP MOTIVASI BELAJAR DARING PADA MAHASISWA PROGRAM STUDI PENDIDIKAN EKONOMI UNIVERSITAS MULAWARMAN
Authors: Amaliati Ayu , Ellyawati Noor , Rahayu Vitria Puri 
Published: February 2023

Pendidikan saat ini sudah berkembang sangat pesat, pembelajaran dilakukan melalui jaringan internet yang dapat dilakukan kapan saja, pada pembelajaran yang dilakukan secara daring ini mahasiswa juga memelukan dukungan orang tua dalam proses pembelajaran agar meningkatkan motivasi mahasiswa dalam belajar secara daring.Penelitian ini dilakukan untuk mengetahui bagaimana pengaruh dukungan orangtua terhadap motivasi belajar daring pada mahasiswa Program Studi Pendidikan Ekonomi Universitas Mulawarman.
Penelitian ini merupakan penelitian kuantitatif dengan jenis penelitian Asosiatif Kausal, pengumpulan data dilakukan dengan menyebarkan kuisioner dan wawancara kepada mahasiswa Program Studi Pendidikan Ekonomi Universitas Mulawarman. Berdasarkan hasil analisis menunjukan bahwa dukungan orang tua mempunyai pengaruh yang signifikan terhadap motivasi belajar daring.
ANALISIS PROFITABILITAS PT PEGADAIAN (PERSERO) SYARIAH SEBELUM DAN SESUDAH ADANYA PRODUK PEMBIAYAAN ARRUM TAHUN 2004-2018
Authors: Wulandari Sekar Wangi , Sudarman Sudarman , Haidar Kadori 
Published: February 2023

Tujuan dari penelitian ini adalah untuk Mengetahui adanya perbedaan profitabilitas PT. Pegadaian (Persero) Syariah sebelum dan sesudah adanya produk pembiayaan Arrum tahun 2004-2018, penelitian ini merupakan jenis penelitian komparatif kuantitatif, yang didalamnya terdapat metode pendekatan penelitian secara statistik deskriptif, yang fungsinya untuk mengetahui perbedaan dan menganalisis profitabilitas PT. Pegadaian (Persero) Syariah sebelum dan sesudah adanya produk pembiayaan Arrum tahun 2004-2018. Hasil analisis data pada variabel ROA, dengan membandingkan kinerja keuangan PT Pegadaian (Persero) Syariah sebelum dan sesudah adanya produk pembiayaan Arrum, diperoleh nilai t sebesar -1,597 dengan signifikansi 0,189. Karena nilai signifikansi lebih besar dari 0,05 (0,189>0,05) maka H0 diterima dan Ha ditolak. Untuk variabel ROE, diperoleh nilai t sebesar -4,634 dengan signifikansi 0,019. Karena nilai signifikansi lebih kecil dari 0,05 (0,019<0,05) maka H0 ditolak dan Ha diterima. Untuk variabel NPM, diperoleh nilai t sebesar -5,319 dengan signifikansi 0,008. Karena nilai signifikansi lebih kecil dari 0,05 (0,006<0,05) maka H0 ditolak dan Ha diterima.
ANALISIS PENERAPAN STANDAR AKUNTANSI KEUANGAN BERDASARKAN SAK ETAP PADA KOPERASI PERTANIAN SEMOGA JAYA DI KABUPATEN KUTAI TIMUR
Authors: Faraidhika Fenni , Haidar Kadori , Abu Ilham 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui kesesuaian laporan koperasi pertanian Semoga Jaya dengan SAK ETAP. Koperasi sebagai entitas tanpa akuntabilitas publik yang cukup berkembang di Indonesia sewajarnya telah mengetahui serta menerapkan standar yang tepat sebagai acuan pembuatan laporan keuangan. Berdasarkan hasil pengamatan terlihat bahwa laporan keuangan yang dihasilkan koperasi belum menyajikan gambaran umum koperasi, dan informasi tentang dasar dalam penyusunan laporan keuangan. Koperasi Pertanian Semoga Jaya termasuk dalam golongan entitas tanpa akuntabilitas publik sehingga untuk menghasilkan laporan keuangan yang berkualitas maka dalam menyajikan laporan keuangannya perlu menerapkan SAK ETAP. Jenis penelitian ini menggunakan analisis deskriptif dengan pendekatan kualitatif. Pengumpulan data yang digunakan dalam penelitian ini adalah metode observasi, wawancara, angket dan dokumentasi. Hasil penelitian ini menunjukkan bahwa penerapan akuntansi yang dilakukan oleh koperasi masih sederhana dan belum sesuai dengan SAK ETAP. Hal tersebut karena kurangnya pengetahuan mereka mengenai SAK ETAP serta masih kurangnya sosialisasi ataupun pelatihan dari pihak pemerintah maupun lembaga, sehingga pemahaman akan pentingnya SAK ETAP masih belum dipahami.
The Implementation Of Character Education On Civics Education Subject For Inclusive Students
Authors: Majid Novita , Warman Warman , Wingkolatin Wingkolatin , Selvia Jepopi 
Published: February 2023

This study aims to determine the problems of managing inclusive education in elementary schools in Kutai Kartanegara and formulate a model of inclusive school management. Currently, there are 2400 schools that are members of the Indonesian Integrated Islamic School Network. Almost all schools in Jakarta and West Java have been asked by the government to apply the concept of inclusive education, as well as several schools in other areas that have accepted children with special needs. Various problems arise, and it is felt necessary to find a solution to these problems. In particular, this research answers the questions, namely How to Implement Character Education in Civics Subjects for Inclusive Children. This study uses a qualitative research method with a case study approach. Data was collected through interviews, study of relevant documents and FGD with 6 school leaders from 3 schools providing inclusive education.
The results of the study explain that each inclusive child has their own advantages or learning modalities, so that the learning and management services provided by the school adapt to the child's needs. Then for educators in inclusive schools there is also no need to be afraid because teaching students with special needs already has academic qualifications and competence standards. The inhibiting factors that occur in the implementation of character education in Civics subjects for inclusive students are internal factors (from students and school management), as well as external factors (derived from government policies and the implementation of inclusive education). the efforts made by schools in the implementation of character education in Civics subjects for inclusive students are: (1) schools still labeled with special needs children, services are provided by classroom teachers and special teachers work in teams; (2) schools without being labeled with ABK, services are provided by classroom/maple teachers equipped with PLB competencies and working in permanent teams; (3) learning in class is done individually, although there are some children who have the same learning needs; and (4) multimodality-based learning with a multilevel curriculum.
ACTIVITY OF SOLAR SCREEN FROM AVOCODO SKIN EXTRACT (PERSEA AMERICANA MILL.) IN VITRO
Authors: Masruhim Muh. Amir , Fitriani Nurul , Rahmatiyah Rahmatiyah 
Published: February 2023

Sunscreen is a preparation that is used on the surface of the skin that works to absorb, scatter or reflect ultraviolet light. Therefore, it is necessary to use the ingredients to become active ingredients in sunscreen. The research objectives are to (a) To determine the total flavonoid content and total polyphenol content of avocado peel extract (Persea americana Mill.). (b) Knowing the sunscreen activity of avocado skin extract (Persea americana Mill.). This type of exploratory experimental research is based on a quantitative approach. The results showed that avocado skin extract (Persea americana Mill.) has a total flavonoid content of 10.855 mgQE/g extract and a total polyphenol content of 221.593 mgGAE/g extract. It is known that avocado peel extract (Persea americana Mill.) has sunscreen activity with an SPF value of 3.887 at a concentration of 500 ppm including minimal protection category. The results of the activity test showed that avocado skin sunscreen potential had phenolic comp