bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐world clinical outcomes of the combination of anti‐PD‐1 antibody, trastuzumab, and chemotherapy for HER2‐positive gastric/gastroesophageal junction cancer
Authors: Yang Ju , Shi Zhan , Zhang Xin , Liu Qin , Cui Xiaobin , Li Lin , Liu Baorui , Wei Jia 
Published: March 2023

AbstractBackgroundPrevious clinical trials indicated the addition of anti‐PD‐1 antibody remarkably improved the efficacy of trastuzumab and chemotherapy in patients with HER2‐positive gastric/gastroesophageal junction (GEJ) cancer. However, no real‐world experiences have been reported yet.MethodsWe retrospectively analyzed 1212 patients with gastric/GEJ cancer treated at Nanjing Drum Tower Hospital between 2019 and 2022. Among 138 patients with HER2‐positive gastric/GEJ cancer, 47 patients receiving at least two doses of the combination regimen with anti‐PD‐1 antibody, trastuzumab, and chemotherapy were recruited in the study population, and 38 out of 47 patients with measurable disease were included in the efficacy population. Progression‐free survival (PFS), objective response rate (ORR), disease control rate (DCR), and toxicity profiles were reported.ResultsIn the study population, 37 (78.7%) received the study therapy as a first‐line treatment. In the efficacy population, the ORR and DCR were 76.3% and 94.7%, respectively. The overall median PFS was 9.1 months (95% confidence interval [CI] 6.3–11.9 months). For the first‐line treatment, the mPFS was 10 months, and 7 months for the second‐line. Among 14 patients who failed the study treatment, three (21.4%) developed brain metastasis as the first failure site. No significant association was found between PFS and the expression of PD‐L1. 22.2% of patients developed grade 3 treatment‐related adverse events (TRAEs). No treatment‐related grade ≥4 adverse events or deaths occurred.ConclusionThis real‐world study validated the combination regimen's high efficacy and good tolerance in patients with HER2‐positive gastric/GEJ cancer. An increased incidence of brain metastasis was observed in patients who failed this regimen.
AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma
Authors: Matsumoto Minoru , Ohmura Takuya , Hanibuchi Yuto , Ichimura‐Shimizu Mayuko , Saijo Yasuyo , Ogawa Hirohisa , Miyazawa Ryuichiro , Morimoto Junko , Tsuneyama Koichi , Matsumoto Mitsuru , Oya Takeshi 
Published: March 2023

AbstractDespite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC‐specific transcriptional regulator that is required for immunological self‐tolerance. We found that a large proportion of TCs expressed AIRE with typical nuclear dot morphology by immunohistochemistry. AIRE expression in TCs was supported by the RNA‐seq data in the TCGA‐THYM database. Furthermore, our bioinformatics approach to the recent single‐cell RNA‐seq data on human thymi has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations. In contrast, TCs lacked the gene signatures for cTECs. We propose that TCs are tumors derived from mTECs.
Perceived brand authenticity: Examining the effects of inferred dedication and anticipated quality on consumers' purchase intentions and actual choices
Authors: Rixom Jessica M. , Rixom Brett A. 
Published: March 2023

AbstractThis research investigates both the downstream effect of perceived brand authenticity on consumers' actual, consequential choice and the important role of inferred brand dedication in the relationship between perceived brand authenticity, anticipated quality, and purchase intentions. We also investigate the interactive effect of two source‐related factors—intrinsic motivation and congruity—on consumers' brand authenticity perceptions. We present findings from three studies using different product categories (utilitarian/consumable: hand sanitizer; hedonic/consumable: chocolate; hedonic/non‐consumable: sunglasses). Study 1 shows that consumers use information regarding the intrinsic motivation of those behind the brand and congruity between the brand's actions and what it represents to consumers when forming brand authenticity perceptions and that intrinsic motivation and congruity interact to increase authenticity perceptions. We anticipate that consumers' positivity toward brands perceived as authentic will extend to actual choice through anticipated quality. Study 2 demonstrates that consumers choose authentic brands over inauthentic brands above what chance would dictate and anticipated quality can forecast this choice. Next, we extend our collective process knowledge by exploring an underlying reason why consumers anticipate that brands presented through marketing communications as authentic will have higher quality. We suggest that when managers present brands as authentic, consumers infer greater dedication of those behind the brand and inferred dedication influences anticipated product quality. Study 3 provides support and uncovers a serial mediation process, highlighting the importance of inferred dedication. Specifically, perceived brand authenticity increases consumers' brand dedication inferences, which in turn increases anticipated product quality, and ultimately purchase intentions.
Solid‐Phase Lipase‐CuNPs Biohybrids as Catalysts for One‐Pot Parallel Synthesis of 2,3,4‐Triacetyl‐D‐Gluconic Acid
Authors: Losada‐Garcia Noelia , Urriolabeitia Esteban P. , Palomo Jose M. 
Published: March 2023

AbstractSolid‐phase lipase/metal nanobiohybrids, generated by growth of copper nanoparticles on enzyme matrixes immobilized on graphene, were used as heterogeneous catalysts with dual‐activity for the regioselective production of 2,3,4‐triacetyl‐D‐gluconic acid from α‐peracetylated‐glucose in a one‐pot parallel process combining a lipase‐mediated regioselective hydrolytic monodeprotection with a metal‐catalyzed oxidation in aqueous media. A novel synthetic strategy, based on the in situ fabrication of Cu nanoparticles induced by lipase molecules specifically immobilized on a multi‐layer graphene material by interfacial adsorption fixing them in the active open conformation, has been described. Thermomyces lanuginosus lipase was firstly used to prepare the functionalized multi‐layer graphene from graphite as a biographene preparation (Biographene, BIOG), support used to successfully immobilize Candida rugosa lipase (CRL). This immobilized form BIOG‐CRL was further used to create successful active bifunctional enzyme‐metal nanoarchitectures. Two different Cu‐lipase hybrids were synthesised, where Cu species and nanoparticles size were different depending on the methodology. Regioselectivity and stability of the hybrids were evaluated successfully in the production of monosaccharide building blocks, besides the robustness of the hybrids in recyclability experiments. These findings highlight the potential of these solid‐phase nanoarchitectures as useful tools in the synthesis of complex glycoderivatives for use in food, medicine, and cosmetics.
Messebericht ACHEMA 2022: Klassieren und Sortieren
Authors: Mütze Thomas 
Published: March 2023

AbstractAuf der ACHEMA 2022 waren in Frankfurt 25 Anbieter von Klassierer‐, Sortier‐, Recycling‐ oder Aufbereitungsanlagen im engeren Sinne vertreten. Der vorliegende Bericht fasst kurz zusammen, welche Aussteller ihr Portfolio im Bereich der Mechanischen Prozesse vorstellten und was an Neuerungen gezeigt wurde. Schwerpunkte stellten u. a. Plan‐ und Taumelsiebmaschinen sowie Technologien für schnelle Siebbelagswechsel und zum Entfernen von Körnern außerhalb der Produktspezifikation dar.
A Mouse Model of MC903‐Induced Atopic Dermatitis
Authors: Alam Md Jahangir , Xie Liang , Yap Yu‐Anne , Robert Remy 
Published: March 2023

AbstractAtopic dermatitis (AD) is a chronic, relapsing, and extremely pruritic inflammatory skin disease with a particular impact on children. AD pathogenesis is not yet fully understood, and there is no curative treatment for this disease. Therefore, several genetically or chemically‐induced AD mouse models have been developed. These preclinical mouse models are an indispensable research tool for studying AD pathogenesis and evaluating the efficacy of new candidate AD therapeutics. A commonly used mouse model of AD has been developed using the topical application of a low‐calcemic analog of vitamin D3, MC903, to induce AD‐like inflammatory phenotypes that closely resemble human AD. Moreover, this model shows a minimal effect on systemic calcium metabolism that is observed in the vitamin D3‐induced AD model. Thus, an expanding number of studies use the MC903‐induced AD model to interrogate AD pathobiology in vivo and to test new candidate small molecule and monoclonal antibody therapies. This protocol describes in detail functional measurements including the measurement of skin thickness, which is a surrogate marker for ear skin inflammation, as well as itch assessment, histological evaluation to assess the structural changes associated with AD skin inflammation, and preparation of single‐cell suspensions from ear skin and draining lymph nodes for the assessment of inflammatory leukocyte subset infiltration in these tissues using flow cytometry. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Topical application of MC903 induces AD‐like skin inflammationSupport Protocol 1: Measurement of ear skin thicknessSupport Protocol 2: Itch assessmentSupport Protocol 3: Dissection of ear skin and ear draining lymph nodesSupport Protocol 4: Histological evaluation and quantificationSupport Protocol 5: Preparation of single‐cell suspension from ear skin and draining lymph nodes for the assessment of inflammatory immune cell infiltration using flow cytometry
The role of individual social responsibility and corporate social responsibility in the tax fraud war: A comparison between the priorities of Italian and Romanian consumers
Authors: Gazzola Patrizia , Paterson Audrey , Amelio Stefano , Grechi Daniele , Cristina Stefano 
Published: March 2023

AbstractCorporate social responsibility (CSR) and fiscal responsibility have become a hot topic of debate in recent years. Many studies have investigated CSR and tax avoidance; however, such studies have overlooked countries' tax cultures and fiscal responsibility from a historical perspective and have not addressed how these elements affect current tax avoidance practices. Using a questionnaire, that was administered to a sample of Italian and Romanian respondents, and inferential techniques (Mann–Whitney‐test and correlation‐test) the paper tries to understand the aspects that be useful in the future development and implementation of more robust fiscal ISR and CSR processes. Our results reveal similarities and differences between the relevance of certain aspects between countries, identifying tax culture as a distinctive element from a geographical point of view. Despite the considerable differences, we found a strong demand for greater transparency of the company with administrations and communities and desire for the development of initiatives to spread a responsible tax culture.
Adipocytokine correlates of childhood and adolescent mental health: A systematic review
Authors: Scott Samantha R. , Millwood Summer N. , Manczak Erika M. 
Published: March 2023

AbstractThe objective of this systematic review was to determine the current state of the literature regarding how adipocytokines associate with mental health symptoms/disorders in youth. Findings summarized in this review suggested that in neurodevelopmental disorders, higher levels of leptin, ghrelin, resistin, and visfatin as well as lower levels of adiponectin, retinol‐binding protein 4, and progranulin predicted increased risk for or were conflated with autism spectrum disorder. Adipocytokine correlates of attention‐deficit hyperactivity disorder and related symptoms included higher apelin, higher leptin‐to‐adiponectin ratio, and lower adiponectin. Evidence from studies examining anxiety symptoms evinced mixed results regarding leptin, and one study suggested higher levels of ghrelin. Depressive symptoms correlated with higher leptin and ghrelin. Research examining posttraumatic stress symptoms found higher levels of ghrelin. In research examining broadband symptoms, conflicting results emerged for associations between internalizing symptoms (i.e., symptoms of emotional stress) and leptin in youth. Low levels of adiponectin and high levels of leptin predicted externalizing symptoms. Total symptom difficulties were associated with a higher leptin‐to‐adiponectin ratio. Our findings suggest that adipocytokines may be an important set of biomarkers to consider as underlying mechanisms contributing to developmental psychopathology.
Can morphological traits explain species‐specific differences in meta‐analyses? A case study of forest beetles
Authors: Staton Tom , Girling Robbie D. , Redak Richard A. , Smith Sandy M. , Allison Jeremy D. 
Published: March 2023

AbstractMeta‐analyses have become a valuable tool with which to synthesize effects across studies, but in ecology and evolution, they are often characterized by high heterogeneity, where effect sizes vary between studies. Much of this heterogeneity can be attributed to species‐specific differences in responses to predictor variables. Here, we aimed to incorporate a novel trait‐based approach to explain species‐specific differences in a meta‐analysis by testing the ability of morphological traits to explain why the effectiveness of flight‐intercept trap design varies according to beetle species, a critical issue in forest pest management. An existing morphological trait database for forest beetles was supplemented, providing trait data for 97 species, while data from a previous meta‐analysis on capture rates of bark or woodboring beetles according to different trap designs were updated. We combined these sources by including nine morphological traits as moderators in meta‐analysis models, for five different components of trap design. Traits were selected based on theoretical hypotheses relating to beetle movement, maneuverability, and sensory perception. We compared the performance of morphological traits as moderators versus guild, taxonomic family, and null meta‐analysis models. Morphological traits for the effect of trap type (panel vs. multiple‐funnel) on beetle capture rates improved model fit (AICc), reduced within‐study variance (σ2), and explained more variation (McFadden's pseudo‐R2) compared with null, guild, and taxonomic family models. For example, morphological trait models explained 10% more of the variance (pseudo‐R2) when compared with a null model. However, using traits was less informative to explain how detailed elements of trap design such as surface treatment and color influence capture rates. The reduction of within‐study variance when accounting for morphological traits demonstrates their potential value for explaining species‐specific differences. Morphological traits associated with flight efficiency, maneuverability, and eye size were particularly informative for explaining the effectiveness of trap type. This could lead to improved predictability of optimal trap design according to species. Therefore, morphological traits could be a valuable tool for understanding species‐specific differences in community ecology, but other causes of heterogeneity across studies, such as forest type and structure, require further investigation.
Modeling long‐distance seed dispersal of the invasive tree Spathodeacampanulata in the Society Islands
Authors: Larrue Sébastien , Baray Jean‐Luc , Chadeyron Julien , Meyer Jean‐Yves , Mazal Lucas , Daehler Curtis C. , Fumanal Boris 
Published: March 2023

AbstractLong‐distance dispersal is a key factor explaining the success of invasive alien species, particularly across oceanic islands. However, it is often not feasible to reliably measure long‐distance seed dispersal (LDD) over many kilometers in the field. Here, we used a three‐dimensional kinematic trajectory model (Computing Atmospheric Trajectory tool [CAT]) initiated on the basis of regional wind field data to assess the potential for LDD of a wind‐dispersed invasive tree, Spathodea campanulata (African tulip tree), across the Society Islands (French Polynesia, South Pacific Ocean) following its initial planting and spread on the island of Tahiti. The main objective of our study was to determine whether S. campanulata could be expected to spread naturally among islands. Atmospheric dynamics, seed terminal velocity, precipitation, and temperature of air masses were considered to assess the potential for LDD between oceanic islands, with the island of Tahiti serving as the island source for multiple, geographically distant invasions. Aerial trajectories of modeled S. campanulata seeds indicated that wind‐dispersed seeds originating from trees on the island of Tahiti could reach most of the Society Islands and disperse as far as 1364 km. This result suggests that Spathodea can be expected to spread naturally among the Society Islands. When rainfall events were modeled as causal agents of seed settlement, fewer seeds reached distant islands, but more seeds settled on the closest island (20 km away). Including effects of island topography (“barrier effects”) also resulted in more seeds settling on the closest island and fewer seeds reaching the most distant islands. Overall, our findings suggest that recent atmospheric models can provide valuable insights into LDD and invasion patterns of wind‐dispersed invasive species.
Not all temperate deciduous trees are leafless in winter: The curious case of marcescence
Authors: Heberling J. Mason , Muzika Rose‐Marie 
Published: March 2023

AbstractTemperate deciduous forests by definition include a large proportion of woody species that shed their leaves each autumn and are completely leafless during winter months. Leaf senescence in deciduous trees is an active, complex process typically involving the physiological formation of an abscission layer causing the petiole to mechanically detach from the branch. However, several deciduous species retain all or some senesced leaves on branches through much of winter, a phenomenon called leaf marcescence. Marcescence has long fascinated botanists, including Pehr Kalm as early as 1749. Yet, surprisingly little research has been done to date. Here, we review and explore patterns and mechanisms of leaf marcescence in temperate forests, bringing together six nonmutually exclusive but separately proposed hypotheses: (1) Marcescence has no adaptive function but rather an evolutionary byproduct; (2) Marcescent leaves deter winter browsing herbivores; (3) Leaf retention through winter improves nutrient resorption during autumn senescence; (4) Prolonged leaf shedding into spring minimizes nutrient leaching and promotes decomposition; (5) Marcescent leaves protect overwintering buds from frost or desiccation; and (6) Marcescent canopies provide winter cover for animals (including insects, birds, bats), thereby affecting plant nutrient availability via excrement. No hypothesis has complete support and few tests of multiple hypotheses have been done. It is likely that any adaptive value of marcescence is species and context dependent. Despite increased interest in plant phenology and prevalence of this trait, much remains to be understood on the physiology, evolution, function, and ecological implications of leaf marcescence.
The influence of inherent soil factors and agricultural management on soil organic matter
Authors: Richardson Gregory S. , Ruark Matthew D. , Radatz Timothy , Radatz Amber , Cooley Eric , Silva Erin M. , Augarten Abigail J. , Zhu Jun , Zegler Chelsea H. 
Published: March 2023

AbstractThe accumulation of soil organic matter (SOM) is vital to the agronomic and environmental functioning of agroecosystems, yet the relative influence of inherent soil properties and agricultural management practices on SOM dynamics are not often addressed in individual studies. Using a network of 218 operating farm fields across Wisconsin and southern Minnesota, USA, this research employs single variable analysis (ANOVA and regression) and regression tree analysis to assess the effects of soil properties (texture, drainage class, and pH) and management variables related to crop rotation, tillage, cover cropping, and manure application on SOM, as well as total organic carbon (TOC) and total nitrogen (TN) in the upper 15 cm. Single variable analysis revealed that greater SOM, TOC, and TN were associated with poorly drained soil, tile‐drained fields, high clay content soil, and high biomass crop rotations. SOM and TOC were strongly related (R2 = 0.71), but different regression trees were produced; SOM was most influenced by clay content, while TOC was most influenced by drainage class. Future assessment for the building of SOM or TOC should be conducted with drainage and texture class categories and on a regional basis, given that these factors influence the practices that occur within landscapes. A rapid building of datasets through unstructured sampling, including an abundance of metadata, should be a research priority in agricultural science to identify practices to build SOM on a regional basis.
Diagnostic pathways to wild‐type transthyretin amyloid cardiomyopathy: a multicentre network study
Authors: Tini Giacomo , Milani Paolo , Zampieri Mattia , Caponetti Angelo G. , Fabris Francesca , Foli Andrea , Argirò Alessia , Mazzoni Carlotta , Gagliardi Christian , Longhi Simone , Saturi Giulia , Vergaro Giuseppe , Aimo Alberto , Russo Domitilla , Varrà Guerino G. , Serenelli Matteo , Fabbri Gioele , De Michieli Laura , Palmiero Giuseppe , Ciliberti Giuseppe , Carigi Samuela , Sessarego Eugenio , Mandoli Giulia E. , Ricci Lucchi Giulia , Rella Valeria , Monti Enrico , Gardini Elisa , Bartolotti Michela , Crotti Lia , Merli Elisa , Mussinelli Roberta , Vianello Pier Filippo , Cameli Matteo , Marzo Francesca , Guerra Federico , Limongelli Giuseppe , Cipriani Alberto , Perlini Stefano , Obici Laura , Perfetto Federico , Autore Camillo , Porto Italo , Rapezzi Claudio , Sinagra Gianfranco , Merlo Marco , Musumeci Beatrice , Emdin Michele , Biagini Elena , Cappelli Francesco , Palladini Giovanni , Canepa Marco 
Published: March 2023

AimEpidemiology of wild‐type transthyretin cardiac amyloidosis (ATTRwt‐CA) remains poorly defined. A better characterization of pathways leading to ATTRwt‐CA diagnosis is of key importance, and potentially informative of disease course and prognosis. The aim of this study was to describe the characteristics of contemporary pathways leading to ATTRwt‐CA diagnosis, and their potential association with survival.Methods and resultsThis was a retrospective study of patients diagnosed with ATTRwt‐CA at 17 Italian referral centres for CA. Patients were categorized into different ‘pathways’ according to the medical reason that triggered the diagnosis of ATTRwt‐CA (hypertrophic cardiomyopathy [HCM] pathway, heart failure [HF] pathway, incidental imaging or incidental clinical pathway). Prognosis was investigated with all‐cause mortality as endpoint. Overall, 1281 ATTRwt‐CA patients were included in the study. The diagnostic pathway leading to ATTRwt‐CA diagnosis was HCM in 7% of patients, HF in 51%, incidental imaging in 23%, incidental clinical in 19%. Patients in the HF pathway, as compared to the others, were older and had a greater prevalence of New York Heart Association (NYHA) class III–IV and chronic kidney disease. Survival was significantly worse in the HF versus other pathways, but similar among the three others. In multivariate model, older age at diagnosis, NYHA class III–IV and some comorbidities but not the HF pathway were independently associated with worse survival.ConclusionsHalf of contemporary ATTRwt‐CA diagnoses occur in a HF setting. These patients had worse clinical profile and outcome than those diagnosed either due to suspected HCM or incidentally, although prognosis remained primarily related to age, NYHA functional class and comorbidities rather than the diagnostic pathway itself.