bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between marital quality and diabetes mellitus: A systematic review
Authors: Rastkar Mohsen , Jalalifar Erfan 
Published: February 2023

AbstractBackground and AimsMarital relationship and its quality are among the major psychological factors affecting the multiple aspects of a person's health status. Chronic diseases are also among the factors that affect various aspects of the lives of millions of people including their marital quality status. One of the most important underlying chronic diseases is diabetes. Since the correlation between diabetes mellitus and marital quality has been neglected, this systematic review, as the first one, aims to investigate the association between marital quality and diabetes mellitus.MethodsA comprehensive search was conducted among three databases (Medline, Scopus, and Web of Science) until September 2021, which resulted in 189 articles. After assessing the studies based on the inclusion criteria, 14 studies were included.ResultsThe included studies were divided into two general groups. The first group consisted of 3 articles examining the effect of factors related to diabetes on marital quality, and the second group included 11 articles studying the effect of marital quality on diabetes and its factors. In general, the articles investigating the impact of diabetes‐related factors on marital quality showed that diabetes has negative impacts on levels of marital quality. Also, the articles investigating the impact of marital quality on diabetes‐related factors, showed that higher marital quality is associated with a lower risk of developing diabetes, a better quality of life in patients with diabetes, and better adherence to diabetes care regimen. The results regarding diabetes management were conflicting. Gender was mentioned as an important modulator in some of the investigated relationships.ConclusionMarital quality remarkably influences diabetes‐related factors and is itself affected by the condition resulting from diabetes in individuals with diabetes mellitus. However, further studies are required due to the limited number of studies investigating this correlation.
Comprehensive medication management: Review and recommendations for quality measures
Authors: Haas Curtis E. , Kliethermes Mary Ann , Armistead Lori T. , Beavers Craig , Schumacher Christie , Smith Lisa , Armitstead John A. , Emmons Roshni P. , Darakjian Lucy , Edwards Krystal L. , Barr Michael ,   the Get the Medications Right Institute
Published: February 2023

AbstractComprehensive medication management (CMM) provided by a clinical pharmacist can improve the quality of care and reduce health care costs through the optimization of medication use and a significant reduction in medication‐related problems. As demonstrated by multiple research studies and detailed in published use cases, CMM should be an essential practice for improving population health. This narrative review discusses the limitations of the current evidence and recommends structure, process, and outcome measures to ensure that the key elements of CMM that drive the observed benefits are implemented with fidelity to address the goals of the quadruple aim. The proposed outcome measures are further sub‐classified into economic, clinical, and humanistic categories. Several medication‐related measures are recommended to help define the importance and value of CMM as a key component of population health management.
Changes in Chinese adolescent college students' psychological security during 2004–2020: A cross‐temporal meta‐analysis
Authors: Zhang Heyun , Zhao Huanhuan 
Published: February 2023

AbstractIntroductionPsychological security is the outcome of interaction between individuals and society, and it is an important indicator reflecting adolescent mental health and self‐growth. Previous studies have paid more attention to external security, but less attention to individual's internal psychological security. In addition, few previous studies have examined the changes of psychological security over time and the influence of socio‐cultural environmental factors on psychological security.MethodsA cross‐temporal meta‐analysis was performed using papers that measured the psychological security level of Chinese adolescent college students between 2004 and 2020. Moreover, a time‐lag analysis was conducted to define whether the macro‐social indicators can explain the changes in Chinese adolescent college students' psychological security.Results(1) A total of 85 papers was included in the final sample (included 48,817 Chinese adolescent college students); (2) the scores of psychological security and its two sub‐dimensions were significantly negatively correlated with the year, indicating that Chinese college students' psychological security declined significantly over time; (3) seven macro social indicators from the socioeconomic environmental, social connectedness and overall social threats can predict the changes in college students' psychological security; (4) the psychological security of male and female college students decreased over time, but the gender difference was insignificant.ConclusionsEvidently, social changes play an important role in predicting changes in Chinese college students' psychological security. The results can provide a research basis for the mental health education of adolescent college students, and also provide an explanation perspective for the increasingly serious “involution” phenomenon among Chinese college students.
The effect of parental alcohol use on alcohol use disorder in young adulthood: Exploring the mediating roles of adolescent alcohol expectancies and consumption
Authors: Stephenson Mallory , Heron Jon , Bountress Kaitlin , Hickman Matthew , Kendler Kenneth S. , Edwards Alexis C. 
Published: February 2023

AbstractIntroductionParental alcohol use and problems are risk factors for alcohol use disorder (AUD), and these effects may be mediated by adolescent alcohol expectancies and consumption. In the present study, we tested the direct effects of mothers' and fathers' alcohol consumption on young adult AUD, as well as the indirect effects through adolescent maximum alcohol use, alcohol consumption, and alcohol expectancies.MethodsParticipants were 5160 individuals (49.1% female) and their biological parents from the Avon Longitudinal Study of Parents and Children, a cohort study of children born in southwestern England during 1991 and 1992. Structural equation modeling (SEM) was used to test associations of mothers' and fathers' alcohol use (assessed when children were 12 years old) with age 24 AUD. Potential mediator variables included the maximum number of alcoholic drinks consumed within a 24‐h period by age 13.5 and alcohol expectancies and alcohol consumption at ages 17 and 20.ResultsHigher maternal and paternal alcohol use were associated with higher levels of alcohol consumption at age 17. Greater alcohol consumption, in turn, was related to a more severe presentation of AUD. The overall indirect effects of mothers' (b = 0.033, 95% confidence interval [CI] = 0.006, 0.059) and fathers' drinking (b = 0.041, 95% CI = 0.018, 0.064) on AUD were modest but significant, and were primarily comprised of adolescent alcohol consumption rather than alcohol expectancies.ConclusionsOur findings underscore the importance of both mothers' and fathers' drinking for the development of alcohol use and problems across adolescence and young adulthood.
Positive effect of acellular amniotic membrane dressing with immobilized growth factors in skin wound healing
Authors: Laleh Mahsa , Tahernejad Mahrokh , Bonakdar Shahin , Asefnejad Azadeh , Golkar Majid , Kazemi‐Lomedasht Fatemeh , Habibi‐Anbouhi Mahdi 
Published: February 2023

AbstractThe human amniotic membrane dressing has been shown to accelerate the wound healing process in the clinic. In this study, heparin was conjugated to a human Acellular Amniotic Membrane (hAAM) to provide affinity binding sites for immobilizing growth factors. To study the acceleration of the wound healing process, we bound epidermal growth factor and fibroblast growth factor 1 to heparinized hAAMs (GF‐Hep‐hAAMs). The heparinized hAAMs (Hep‐hAAMs) were characterized by toluidine blue staining and infrared spectroscopy. The quality control of hAAM was performed by hematoxylin staining, swelling capacity test and biomechanical evaluation. The cytotoxicity, adhesion, and migration in vitro assays of GF‐Hep‐hAAMs on L‐929 fibroblast cells were also studied by MTT assay, scanning electron microscopy, and scratch assay, respectively. Finally, in vivo skin wound healing study was performed to investigate the wound closure rate, re‐epithelization, collagen deposition, and formation of new blood vessels. The results showed that GF‐Hep‐hAAMs enhance the rate of wound closure and epidermal regeneration in BALB/c mice. In conclusion, GF‐Hep‐hAAMs could accelerate the wound healing process, significantly in the first week.
Molecular mechanisms of miR‐1236 in the assessment of tumor lymphangiogenesis in human ovarian cancer patients
Authors: Khademi Mahsa , Babaei Zeinab , Ghorbanhosseini Seyedeh Sara , Emami Razavi Amirnader , Aghaei Mahmoud 
Published: February 2023

AbstractBackgroundTumor lymphangiogenesis is a critical component in the progression of cancers and specific microRNAs have been reported to be implicated in this process. Recent studies revealed the involvement of miR‐1236 in lymphangiogenic signaling by targeting vascular endothelial growth factor receptor 3 (VEGFR3). However, the prognostic importance of miR‐1236 and its clinical relevance for lymphangiogenesis in ovarian cancer (OC) remains unclear.MethodsThe study included 52 ovarian tumors and 28 normal ovarian tissues. Quantitative real‐time PCR was utilized to analyze the VEGFR3, VEGF‐C, LYVE‐1 and PROX1 mRNA expression as well as miR‐1236. VEGFR3 protein expression was measured by immunohistochemistry staining. Immunohistochemistry for the podoplanin marker (D2‐40) was performed to measure lymphatic vessel density (LVD). In addition, diagnostic evaluation based on the receiver‐operating characteristic (ROC) curve was performed. The influence of miR‐1236 on overall survival was evaluated by Kaplan–Meier method.ResultsHere, we show that miR‐1236 expression was significantly decreased in ovarian tumors compared with control tissues (p < 0.001) and correlated with advanced clinical stage, lymph node metastasis, distant metastasis and patient survival (All P < 0.05). Moreover, in ovarian tumors, LVD as well as the gene expression of VEGFR3, VEGF‐C and LYVE‐1, but not PROX1, were found to be remarkably higher compared with control tissues. We also detected a more robust positive staining for VEGFR3 in OC tissues than in control tissues. Furthermore, our results demonstrated an inverse association of miR‐1236 expression with LVD, VEGFR3, LYVE‐1 and PROX1 expression in OC tissues. The ROC curve analysis indicated that miR‐1236 expression has the potential to be used as a diagnostic and prognostic biomarker in OC. Survival analysis further verified a lowered overall survival rate in patients with low miR‐1236 expression than in those with high expression.ConclusionsOur results provide evidence for the translational involvement of miR‐1236 in the lymphangiogenesis of OC by regulating lymphangiogenesis‐related factors and support the clinical importance of miR‐1236 as a new diagnostic and prognostic biomarker for OC.
Performance analysis of GaN‐FINFET for RFIC application with respect to different FinWidth's
Authors: Reddy M. Nomitha , Panda Deepak Kumar 
Published: February 2023

AbstractGaN has become a prevailing semiconductor in case of power and RF applications. The higher ranking material parameters of GaN, like wider band‐gap, the higher breakdown electric field as well as higher electron velocity when compared to materials like Si, SiC, GaAs etc; allow GaN FINFET to reveal potential advantages such as high voltage and high frequency applications. In this work, a comprehensive study on RF and linearity analysis on Heterojunction‐free GaN layer FINFET through visual technology computer‐aided design (TCAD) device simulator is been illustrated. The influence of varying the Finwidth's of the device on numerous RF parameters like drain current, transconductance (gm), output conductance (gd), gate capacitances(Cgd and Cgs), cut‐off frequency (fT) are studied. And also, the impact of varying the Finwidth's of the device on the numerous linearity parameters like gm2, gm3, VIP3, IIP3, 1 dB compression point were also studied. It is been observed that the higher Finwidth value is more worthy for radio frequency integrated circuit (RFIC) applications.
Effects of precipitation and grazing on the diversity and productivity of desert steppe
Authors: Ye Ruhan , Yu Wanying , Yang Ding , Yi Fengyan , Zhang Pujin , Qiu Xiao , Tuya Wulan , Sun Hailian , Ye Xuehua , Yang Xuejun , Huang Zhenying , Liu Guofang 
Published: February 2023

AbstractThe variability of annual precipitation and grazing are primary drivers shaping the structure and function of plant communities in grasslands. Yet it remains unclear on a mechanistic understanding of how annual precipitation and grazing affect the plant community structure, function, and their linkage via direct or indirect pathways. We measured the plant community structure (plant traits, species abundance, and plant diversity), total aboveground biomass, total cover, and species covers in plant communities in responses to annual precipitation variability from 2014 to 2017 and grazing pressure comprising 0, 0.93, 1.82, and 2.71 sheep ha−1 in a desert steppe. Two‐way ANOVAs, ordinary least square regressions, and the structural equation modeling (SEM) were used to test the impacts of annual precipitation variability and grazing pressure on the plant community structure and function. Results showed that higher annual precipitation of 2016 and 2017 increased the relative abundances of forbs; grazing pressure increased the relative abundances of dominant grasses [Stipa breviflora Griseb. and Cleistogenes songorica (Roshev.) Ohwi], but decreased those of subdominant forbs (Convolvulus ammannii Desr. and Artemisia frigida Willd.). Plant traits, such as leaf nitrogen concentration, regulated plant species abundance directly or indirectly via affecting sheep diet selection. Annual precipitation variability and grazing pressure independently regulated plant diversity, aboveground biomass, and total cover, which the former had larger effects. There was slower decrease in grass biomass than that in forb biomass with increasing grazing pressure, indicating that dominant grasses are resilient to grazing but subdominant forbs are sensitive due to their distinct difference in sward palatability. The positive correlation between plant diversity and aboveground biomass was driven by both annual precipitation variability and grazing pressure. These highlight direct and indirect (via traits and abundances of plant species) effects of annual precipitation and grazing in shaping the structure and function of desert steppe ecosystems.
Land degradation and climate change lessened soil erodibility across a wide area of the southern Tibetan Plateau over the past 35–40 years
Authors: Lin Honghong , Cheng Xiaoli , Bruijnzeel L. Adrian , Duan Xingwu , Zhang Jun , Chen Liding , Zheng Hua , Lu Shaojuan , Dong Yifan , Huang Jiangcheng , Zhong Ronghua , Li Chun 
Published: February 2023

AbstractThe Tibetan Plateau's alpine ecosystem has been undergoing accelerated climate change and severe vegetation degradation in the past four decades, which has triggered a sharp increase in soil erosion hazards. However, the combined impacts of climate change and vegetation degradation on soil erodibility (K) across geographical and temporal scales remain unclear. Here, we present the first systematic investigation of spatio‐temporal variations inKunder different land uses across the southern Tibetan Plateau over the last 35–40 years, and identify the associated driving factors based on a paired resampling campaign conducted in the 1980s and 2020, covering 148 field sites.K‐values derived for the majority of grassland (75.0%) and cropland (66.2%) sites, as well as for a substantial number of forest sites (46.7%) showed a decreasing tendency with time, with average decreases of 31%, 14%, and 5%, respectively. Changes inKwere primarily (17.6%) attributed to soil erosion, but were exacerbated by climate change (8.2%). Interestingly, the declines inKresulted in significant decreases in (predicted) soil erosion rates as long as strong disturbances from climate change and human activities were absent. These findings confirm the existence of a negative feedback mechanism between soil erosion andKin most alpine ecosystems on the southern Tibetan Plateau. Our results reveal the extent to which the impact of vegetation degradation on the magnitude ofKis enhanced by climate change, thereby providing new insights into the feedback between alpine ecosystems, climate change, and anthropogenic interference.
KLF14/miR‐1283/TFAP2C axis inhibits HER2‐positive breast cancer progression via declining tumor cell proliferation
Authors: Chen Xue‐Zhong , He Wen‐Xing , Luo Rong‐Guang , Xia Guo‐Jin , Zhong Jin‐Xiu , Chen Qing‐Jie , Huang Yu‐Ying , Guan Yan‐Xing 
Published: February 2023

AbstractMiR‐1283 has been identified as a tumor suppressor in some malignancies. Whereas, the role of miR‐1283 in HER2‐positive (HER2+) breast cancer, particularly its role in regulating cell proliferation, one of the most significant features of tumor progression, is unclear. The related microRNA screened by the breast cancer sample GSE131599 dataset were detected in HER2+ breast cancer tissues and cell lines. Then, the obtained miR‐1283 was overexpressed in SKBR3 and BT‐474 cells followed by relevant functional assays concerning cell proliferation and apoptosis. The xenograft mouse model was induced and the effect of miR‐1283 on tumor growth and cell proliferation was examined. The target of miR‐1283 and the transcription factor regulating miR‐1283 were predicted and identified. Finally, the influence of transcription factor KLF14 on cell proliferation and apoptosis was investigated. An integrated analysis confirmed that miR‐1283 expression was significantly decreased in HER2+ breast cancer tissues. Also, by q‐RT‐PCR detection, miR‐1283 expression was markedly reduced in HER2+ breast cancer tissues and cell lines. The miR‐1283 overexpression prevented the proliferation and enhanced apoptosis of HER2+ breast cancer cells, as well as inhibited tumor growth. Mechanistically, miR‐1283 inhibited TFAP2C expression by targeting the 3′‐untranslated regions of TFAP2C messenger RNA, and the KLF14 enhanced miR‐1283 level via binding to its promoter. The result subsequently confirmed the KLF14/miR‐1283 signaling suppressed cell proliferation in HER2+ breast cancer. Our results suggested that the KLF14/miR‐1283/TFAP2C axis inhibited HER2+ breast cancer progression, which might provide novel insight into mechanical exploration for this disease.
Neural stem/progenitor cell‐derived extracellular vesicles: A novel therapy for neurological diseases and beyond
Authors: Li Xiangyu , Zhu Yingbo , Wang Yi , Xia Xiaohuan , Zheng Jialin C. 
Published: February 2023

AbstractAs bilayer lipid membrane vesicles secreted by neural stem/progenitor cells (NSCs), NSC‐derived extracellular vesicles (NSC‐EVs) have attracted growing attention for their promising potential to serve as novel therapeutic agents in treatment of neurological diseases due to their unique physicochemical characteristics and biological functions. NSC‐EVs exhibit advantages such as stable physical and chemical properties, low immunogenicity, and high penetration capacity to cross blood–brain barrier to avoid predicaments of the clinical applications of NSCs that include autoimmune responses, ethical/religious concerns, and the problematic logistics of acquiring fetal tissues. More importantly, NSC‐EVs inherit excellent neuroprotective and neuroregenerative potential and immunomodulatory capabilities from parent cells, and display outstanding therapeutic effects on mitigating behavioral alterations and pathological phenotypes of patients or animals with neurological diseases. In this review, we first comprehensively summarize the progress in functional research and application of NSC‐EVs in different neurological diseases, including neurodegenerative diseases, acute neurological diseases, dementia/cognitive dysfunction, and peripheral diseases. Next, we provide our thoughts on current limitations/concerns as well as tremendous potential of NSC‐EVs in clinical applications. Last, we discuss future directions of further investigations on NSC‐EVs and their probable applications in both basic and clinical research.
The use of chimeric‐superthin anterolateral thigh flap in reconstruction of laryngopharyngoesophagectomy defects of hypopharyngeal cancer
Authors: Gur Ersin , Tiftikcioglu Yigit Ozer , Kuybulu Turgut Furkan , Turhal Goksel , Ozturk Kerem 
Published: February 2023

AbstractIntroductionDue to 3D defects after resection of hypopharyngeal cancers, free flaps have become as first option for reconstruction and the anterolateral thigh flap (ALT) has been chosen frequently for soft tissue defects. Chimerization of the skin island of the ALT is also possible which can result in reconstruction of multiple defects simultaneously and monitorization of buried flaps. However, ALT can be bulky in some patients. The superthin ALT is well established by some authors especially for extremities but there is no study about the use of this modification in pharyngoesophageal defects. We present our experience of using chimeric‐superthin ALT for pharyngoesophageal reconstructions.Patients and MethodsBetween 2019 and 2022, six patients (one female and five male) underwent hypopharyngeal tumor resection and experienced chimeric‐superthin ALT flap reconstructions. Patients' ages were ranged between 53 and 71 (mean: 64) years old. The type of tumor was squamous cell carcinoma (SCC) for all patients. Three patients had total and three patients had 75% of pharyngoesophageal defects. Defect size was between 10 × 7 cm and 12 × 8.5 cm (mean: 87.08 cm2). All flaps were harvested as 5 mm thickness with two skin perforators. All flaps were divided into two individual skin islands as chimeric fashion. One of the skin islands was used for esophageal reconstruction and the other was used for both flap monitorization and tensionless closure of anterior neck skin.ResultsTotal flap size was between 18 × 9 cm and 21 × 11 cm (mean: 200 cm2). In two patients, anastomoses were performed to pectoral branch of thoracoacromial vessels. Neck vessels were chosen as recipient for remaining patients. Wound dehiscence occurred in two patients between the neck skin and monitor island and was re‐sutured without any problems. There was no partial or total flap necrosis and all flaps survived. The follow up period was between 4 and 9 months (mean: 5.6). All patients had a successful functional outcome as swallowing.ConclusionThe superthin‐chimeric ALT flap is a useful option when classical ALT is bulky in defects of hypopharyngeal cancer.