bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipolar spectrum in prostate cancer patients and its role in stress related symptoms
Authors: Chrobak Adrian Andrzej , Przydacz Mikołaj , Chłosta Marcin , Machalska Karolina , Turek Aleksander , Popiół Maja , Skalski Michał , Arciszewska‐Leszczuk Aleksandra , Chłosta Piotr , Siwek Marcin , Dudek Dominika 
Published: January 2023

AbstractBackgroundStudies show significant co‐occurrence of bipolar disorder and prostate cancer, as well as the presence of shared genes associated with both diseases. Our aim was to evaluate whether prostate cancer patients present bipolar spectrum symptoms and to establish their possible associations with stress related symptoms during diagnosis and the course of the cancer therapy.Methods200 participants were enrolled to this study: 100 prostate cancer patients and 100 healthy males. Bipolar spectrum symptoms were measured with the use of Mood Disorder Questionnaire and Hypomania Checklist‐32 (HCL‐32). Stress related symptoms were rated with The Impact of Events Scale‐Revised (IES‐R), Perceived Stress Scale‐10 (PSS‐10) and Generalised Self‐Efficacy Scale (GSES).ResultsIn comparison to healthy controls group, prostate cancer patients have shown higher HCL‐32 scores. Mood Disorder Questionnaire measures were associated with more severe stress related to prostate cancer diagnosis and treatment reflected by higher scores of IES‐R and its subscales (Avoidance, Intrusions and Hyperarousal). Mood Disorder Questionnaire, HCL‐32, PSS‐10, IES‐R and GSES measures were not associated with clinical characteristics of prostate cancer severity.LimitationsCross‐sectional study model precluded identification of causal relationship among variables. Bipolar spectrum symptoms and stress related measures were based on auto‐questionnaires.ConclusionsTo our best knowledge, this is the first study evaluating bipolar spectrum symptoms in prostate cancer patients. We have shown that this clinical group presents increased bipolarity traits compared to healthy individuals. Moreover, bipolar spectrum symptoms were associated with more severe stress related to the prostate cancer diagnosis and its treatment, reflected in avoidance, hyperarousal, and intrusions.
Foodborne pathogens in Africa: Understanding Cronobacter sakazakii
Authors: Mazi Ifeanyi Michael , Onyeaka Helen , Nnaji Nnabueze Darlington 
Published: January 2023

AbstractCronobacter sakazakii is an emerging and opportunistic foodborne pathogen that causes severe infantile diseases, including meningitis, necrotizing enterocolitis, and septicemia. It has been reported in numerous countries around the world, including those in Africa. Although it has been isolated from food, environmental and clinical samples across Africa, the most implicated source of the C. sakazakii infection outbreaks across the globe has been the consumption of contaminated powdered infant formula. Cronobacter has many unique characteristics that contribute to its survival in harsh environments and transmission along the food chain from production to consumption. A potential foodborne disease outbreak caused by C. sakazakii can increase the overall foodborne disease burden and hinder any progress in managing the overly strained public health situation in Africa. This article presents an insight into the occurrence and prevalence of C. sakazakii infection in Africa's food environment, pointing out the transmission route along the food chain and its accompanying food safety concerns. This paper advocates for strict compliance with food safety and control measures to prevent its spread in African countries.
Theory on Electron–Phonon Spin Dephasing in GaAs Multi‐Electron Double Quantum Dots
Authors: He Guanjie , Chan Guo Xuan , Wang Xin 
Published: January 2023

AbstractRecent studies reveal that a double‐quantum‐dot system hosting more than two electrons may be superior in certain aspects as compared to the traditional case in which only two electrons are confined (a singlet–triplet qubit). The electron–phonon dephasing occurring in a GaAs multi‐electron double‐quantum‐dot system is studied, in a biased case in which the singlet state is hybridized, as well as in an unbiased case in which the hybridization is absent. It is found that while the electron–phonon dephasing rate increases with the number of electrons confined in the unbiased case, this does not hold in the biased case. A merit figure is defined as a ratio between the exchange energy and the dephasing rate, and have shown that in experimentally relevant range of the exchange energy, the merit figure actually increases with the number of electrons in the biased case. The results show that the multi‐electron quantum‐dot system has another advantage in mitigating the effect of electron–phonon dephasing, which is previously under‐appreciated in the literature.
Toward Personalized Nanomedicine: The Critical Evaluation of Micro and Nanodevices for Cancer Biomarker Analysis in Liquid Biopsy
Authors: Clack Kimberley , Soda Narshone , Kasetsirikul Surasak , Mahmudunnabi Rabbee G. , Nguyen Nam‐Trung , Shiddiky Muhammad J. A. 
Published: January 2023

AbstractLiquid biopsy for the analysis of circulating cancer biomarkers (CBs) is a major advancement toward the early detection of cancer. In comparison to tissue biopsy techniques, liquid biopsy is relatively painless, offering multiple sampling opportunities across easily accessible bodily fluids such as blood, urine, and saliva. Liquid biopsy is also relatively inexpensive and simple, avoiding the requirement for specialized laboratory equipment or trained medical staff. Major advances in the field of liquid biopsy are attributed largely to developments in nanotechnology and microfabrication that enables the creation of highly precise chip‐based platforms. These devices can overcome detection limitations of an individual biomarker by detecting multiple markers simultaneously on the same chip, or by featuring integrated and combined target separation techniques. In this review, the major advances in the field of portable and semi‐portable micro, nano, and multiplexed platforms for CB detection for the early diagnosis of cancer are highlighted. A comparative discussion is also provided, noting merits and drawbacks of the platforms, especially in terms of portability. Finally, key challenges toward device portability and possible solutions, as well as discussing the future direction of the field are highlighted.
Prediction of the ultimate axial load of circular concrete‐filled stainless steel tubular columns using machine learning approaches
Authors: Tran Viet‐Linh , Ahmed Mizan , Gohery Scott 
Published: January 2023

AbstractThis paper investigates the accuracy of the existing empirical design models and different machine learning (ML) models, known as Decision Tree (DT), Random Forest (RF), K‐Nearest Neighbors (KNN), Adaptive Boosting (AdaBoost), Gradient Boosting Regression Tree (GBRT), and Extreme Gradient Boosting (XGBoost) in predicting the ultimate axial load of circular concrete‐filled stainless steel tubular (CFSST) columns under axial loading. A test database encompassing the test results of 142 CFSST columns is used to validate the accuracy of the existing empirical design and different ML models. It was demonstrated that all the ML models can provide a better estimation of the ultimate axial load than the existing empirical design models do, in which XGBoost can provide the best estimation of the ultimate axial load of CFSST columns. Finally, a simple equation is proposed based on the XGBoost model for the practical design of CFSST columns.
Associations of abdominal discomfort and length of clinical signs with surgical procedure in 181 cases of canine small intestinal foreign body obstruction
Authors: Schoelkopf Alexander Chase , Stewart Samuel D. , Casale Sue A. , Fryer Katy J. 
Published: January 2023

AbstractBackgroundGastrointestinal foreign bodies are a common indication for abdominal exploratory surgery.ObjectivesThe objective of this study was to evaluate the relationship of pre‐operative abdominal discomfort and duration of clinical signs with surgical resolution of canine small intestinal foreign body obstructions (SIFBO).MethodsWe performed a retrospective study of 181 canine abdominal exploratory surgeries for confirmed SIFBO at two referral hospitals. Animals were categorized into five surgical groups (gastrotomy after manipulation into the stomach, enterotomy, resection‐and‐anastomosis [R&A], manipulated into colon, already in colon) and further grouped by whether entry into the gastrointestinal tract (GIT) was required.ResultsAbdominal discomfort was noted in 107/181 cases (59.1%), but no significant differences in abdominal discomfort rates were present among the surgical groups or between GIT entry and no entry groups. Clinical sign duration was associated with surgical procedure; median durations were R&A = 3 days (range, 1–9), enterotomy = 2 days (range, 1–14), gastrotomy = 2 days (range, 1–6), already in colon = 1.5 days (range, 1–2), and manipulated into colon = 1 day (range, 1–7). In a pairwise comparison, differences in the duration of clinical signs were found for obstructions manipulated into the colon versus R&A, gastrotomy versus R&A, and in colon versus R&A. When patients were grouped according to GIT entry, cases with entry had a longer duration of clinical signs (median = 2 days [range, 1–14] versus 1 day [range, 1–7], respectively).ConclusionsAbdominal discomfort was not associated with surgical complexity; however, the duration of clinical signs was associated with surgical complexity, with longer duration being associated with entry into the GIT and R&A. Despite statistical significance, the maximum difference of 2 days between surgical groups is unlikely to be clinically relevant.
Effect of oestrus synchronisation through ovulation delay by vaccination against foot‐and‐mouth disease in Hanwoo (Bos taurus coreanae) cows
Authors: Kim Daehyun , Kwon Woo‐Sung , Ha Jaejung , Kim Jaejo , Kim Danil , Lee Wonyou , Moon Joonho , Yi Junkoo 
Published: January 2023

AbstractBackgroundIn Korean cattle, after foot‐and‐mouth disease (FMD) vaccination, anovulation increases, acute immune response is stimulated.ObjectiveHere, we aimed to improve the fertility rate by ovulation delay caused by the foot‐and‐mouth disease vaccine.Methods160 cows (control, FMD, FMD+Gn250 and FMD+Gn500 groups, with 40 cows each) were used. We analysed the ovulation delay, ovulation rate, conception rate and acute‐phase immune responses.ResultsIn the group vaccinated only with FMD, the average follicle size was maintained at 12 mm and ovulation was delayed. The ovulation rate of the FMD+Gn500 group (500 μg gonadotropin‐releasing hormone (GnRH) injections 3 days after the FMD vaccination) was the highest at 81.8%. The ovulation rate of the FMD+Gn250 group (250 μg GnRH injections 3 days after FMD vaccination) was 54.5%, and that of the control group (not FMD vaccinated) was 53.3%. The conception rate was 52.5% (19/40) in the control group, 37.5% (15/40) in the FMD+Gn250 group, and 67.5% (27/40) in the FMD+Gn500 group. Analysis of acute‐phase immune response revealed that the plasma contents of haptoglobin and serum amyloid A increased up to 7 days after vaccination against FMD in all the experimental groups, except the control group.ConclusionsWe concluded that ovulation delay can be employed to improve conception rate after FMD vaccination through a modified ovulation synchronisation method with GnRH.
Functional and regulatory impact of chimeric RNAs in human normal and cancer cells
Authors: Mukherjee Sumit , Mukherjee Sunanda Biswas , Frenkel‐Morgenstern Milana 
Published: January 2023

AbstractFusions of two genes can lead to the generation of chimeric RNAs, which may have a distinct functional role from their original molecules. Chimeric RNAs could encode novel functional proteins or serve as novel long noncoding RNAs (lncRNAs). The appearance of chimeric RNAs in a cell could help to generate new functionality and phenotypic diversity that might facilitate this cell to survive against new environmental stress. Several recent studies have demonstrated the functional roles of various chimeric RNAs in cancer progression and are considered as biomarkers for cancer diagnosis and sometimes even drug targets. Further, the growing evidence demonstrated the potential functional association of chimeric RNAs with cancer heterogeneity and drug resistance cancer evolution. Recent studies highlighted that chimeric RNAs also have functional potentiality in normal physiological processes. Several functionally potential chimeric RNAs were discovered in human cancer and normal cells in the last two decades. This could indicate that chimeric RNAs are the hidden layer of the human transcriptome that should be explored from the functional insights to better understand the functional evolution of the genome and disease development that could facilitate clinical practice improvements. This review summarizes the current knowledge of chimeric RNAs and highlights their functional, regulatory, and evolutionary impact on different cancers and normal physiological processes. Further, we will discuss the potential functional roles of a recently discovered novel class of chimeric RNAs named sense–antisense/cross‐strand chimeric RNAs generated by the fusion of the bi‐directional transcripts of the same gene.This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
Trends and new elements in urban hierarchy research: the Greek paradigm
Authors: Lemonakis Christos , Alexopoulos Georgios , Garefalakis Alexandros , Garefalakis Stavros 
Published: January 2023

AbstractResearch on shrinking cities shows continuous links between this phenomenon and the process of urban decline, which has been analyzed in many works, especially in Greece. The impact on urban development can be positive, while population growth over time is characterized by the degree of its convergence. The aim of this study is to gain a deeper understanding of the challenge of urbanization in large cities. The sample used in this effort consists of 117 Greek cities with more than 10,000 inhabitants in 1994, using econometric tools to identify settlements using Markov chain theory with data from 1994 to 2020 from the Hellenic Statistical Authority. Using Urban Hierarchy Research (UHR), a significant decline in Greek Urban Concentration (GUC) and a continuous increase in the population of small- and medium-sized cities were found. The Greek urban system is moving toward a distribution characterized by the seeding of relatively large cities. The study aims to open a broader research discussion in the field of spatial econometric applications.
Dynamic mosaic planning for a robotic bin-packing system based on picked part and target box monitoring
Authors: Iriondo Ander , Lazkano Elena , Ansuategi Ander , Fernandez Ane , Maurtua Iñaki 
Published: January 2023

AbstractThis paper describes the dynamic mosaic planning method developed in the context of the PICKPLACE European project. The dynamic planner has allowed the development of a robotic system capable of packing a wide variety of objects without having to adjust to each reference. The mosaic planning system consists of three modules: First, the picked item monitoring module monitors the grabbed item to find out how the robot has picked it. At the same time, the destination container is monitored online to obtain the actual status of the packaging. To this end, we present a novel heuristic algorithm that, based on the point cloud of the scene, estimates the empty volume inside the container as empty maximal spaces (EMS). Finally, we present the development of the dynamic IK-PAL mosaic planner that allows us to dynamically estimate the optimal packing pose considering both the status of the picked part and the estimated EMSs. The developed method has been successfully integrated in a real robotic picking and packing system and validated with 7 tests of increasing complexity. In these tests, we demonstrate the flexibility of the presented system in handling a wide range of objects in a real dynamic packaging environment. To our knowledge, this is the first time that a complete online picking and packing system is deployed in a real robotic scenario allowing to create mosaics with arbitrary objects and to consider the dynamics of a real robotic packing system.
Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging
Authors: Ladang Aurélie , Beaudart Charlotte , Reginster Jean-Yves , Al-Daghri Nasser , Bruyère Olivier , Burlet Nansa , Cesari Matteo , Cherubini Antonio , da Silva Mario Coelho , Cooper Cyrus , Cruz-Jentoft Alfonso J. , Landi Francesco , Laslop Andrea , Maggi Stefania , Mobasheri Ali , Ormarsdottir Sif , Radermecker Régis , Visser Marjolein , Yerro Maria Concepcion Prieto , Rizzoli René , Cavalier Etienne 
Published: January 2023

AbstractIn clinical trials, biochemical markers provide useful information on the drug’s mode of action, therapeutic response and side effect monitoring and can act as surrogate endpoints. In pharmacological intervention development for sarcopenia management, there is an urgent need to identify biomarkers to measure in clinical trials and that could be used in the future in clinical practice. The objective of the current consensus paper is to provide a clear list of biochemical markers of musculoskeletal health and aging that can be recommended to be measured in Phase II and Phase III clinical trials evaluating new chemical entities for sarcopenia treatment. A working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) proposed classifying biochemical markers into 2 series: biochemical markers evaluating musculoskeletal status and biochemical markers evaluating causal factors. For series 1, the group agreed on 4 biochemical markers that should be assessed in Phase II or Phase III trials (i.e., Myostatin-Follistatin, Brain Derived Neurotrophic Factor, N-terminal Type III Procollagen and Serum Creatinine to Serum Cystatin C Ratio – or the Sarcopenia Index). For series 2, the group agreed on 6 biochemical markers that should be assessed in Phase II trials (i.e., the hormones insulin-like growth factor-1 (IGF-I), dehydroepiandrosterone sulphate, and cortisol, and the inflammatory markers C-reactive protein (CRP), interleukin-6 and tumor necrosis factor-α), and 2 in Phase III trials (i.e., IGF-I and CRP). The group also proposed optional biochemical markers that may provide insights into the mode of action of pharmacological therapies. Further research and development of new methods for biochemical marker assays may lead to the evolution of these recommendations.
Attentional prioritisation and facilitation for similar stimuli in visual working memory
Authors: Hamblin-Frohman Zachary , Low Jia Xuan , Becker Stefanie I. 
Published: January 2023

AbstractVisual working memory (VWM) allows for the brief retention of approximately three to four items. Interestingly, when these items are similar to each other in a feature domain, memory recall performance is elevated compared to when they are dissimilar. This similarity benefit is currently not accounted for by models of VWM. Previous research has suggested that this similarity benefit may arise from selective attentional prioritisation in the maintenance phase. However, the similarity effect has not been contrasted under circumstances where dissimilar item types can adequately compete for memory resources. In Experiment 1, similarity benefits were seen for all-similar over all-dissimilar displays. This was also seen in mixed displays, change detection performance was higher when one of the two similar items changed, compared to when the dissimilar item changed. Surprisingly, the similarity effect was stronger in these mixed displays then when comparing the all-similar and all-dissimilar. Experiment 2 investigated this further by examining how attention was allocated in the memory encoding phase via eye movements. Results revealed that attention prioritised similar over dissimilar items in the mixed displays. Similar items were more likely to receive the first fixation and were fixated more often than dissimilar items. Furthermore, dwell times were elongated for dissimilar items, suggesting that encoding was less efficient. These results suggest that there is an attentional strategy towards prioritising similar items over dissimilar items, and that this strategy’s influence can be observed in the memory encoding phase.
Cost-effectiveness of ravulizumab compared with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria in the Netherlands
Authors: Quist S. W. , Postma A. J. , Myrén K. J. , de Jong L. A. , Postma M. J. 
Published: January 2023

Abstract
Objectives
The aim of this study was to evaluate the cost-effectiveness of ravulizumab compared with eculizumab for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH) in the Netherlands.

Methods
A cost-effectiveness analysis was conducted based on a Markov cohort model simulating the course of patients with PNH with clinical symptom(s) indicative of high disease activity, or who are clinically stable after having been treated with eculizumab for at least the past six months. Costs, quality of life, and the incremental cost-effectiveness ratio (ICER) were estimated over a lifetime horizon from a Dutch societal perspective. Several additional analyses were performed, including a one-way sensitivity analysis, a probabilistic sensitivity analysis, and scenario analysis.

Results
When compared with eculizumab, ravulizumab saves €266,833 and 1.57 quality adjusted life years (QALYs) are gained, resulting in a dominant ICER. Drug costs account for the majority of the total costs in both intervention groups. Cost savings were driven by the difference in total treatment costs of ravulizumab compared with eculizumab caused by the reduced administration frequency, accounting for 98% of the total cost savings. The QALY gain with ravulizumab is largely attributable to the improved quality of life associated with less frequent infusions and BTH events. At a willingness-to-pay threshold of €20,000/QALY, there is a 76.6% probability that ravulizumab would be cost-effective.

Conclusions
The cost reduction and QALY gain associated with the lower rates of BTH and less frequent administration make ravulizumab a cost-saving and clinically beneficial substitute for eculizumab for adults with PNH in the Netherlands.