bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metrics for size-matching in paediatric cardiac transplantation: A narrative review
Authors: Stinson Griffin P. , Sharaf Omar M. , Valdes Carlos A. , Bilgili Ahmet , Peek Giles J. , Bleiweis Mark S. , Jacobs Jeffrey P. 
Published: January 2025

AbstractSeveral metrics exist for matching the size of donor to recipient in paediatric cardiac transplantation. Different centres employ different metrics for size-matching to determine the viability of donor hearts. Inconsistent evidence exists, with limited consensus as to the metric for size-matching that is most predictive of outcomes after cardiac transplantation. Furthermore, any metric must function within the tight timeline available for the assessment of the suitability of the donor. At the time of the writing of this paper, the most commonly used metric for size-matching in paediatric cardiac transplantation is the donor-to-recipient body weight ratio. In this article, we review published literature evaluating commonly used metrics for size-matching in paediatric cardiac transplantation, including weight, height, body surface area, and imaging parameters.
Neo-aorta reconstruction with retained stented patch in Norwood procedure after hybrid palliation of high-risk hypoplastic left heart syndrome: a case report
Authors: Lim Su Chan , Kwon Hye Won , Cho Sungkyu , Lee Sang-Yun 
Published: January 2025

AbstractHybrid procedure of hypoplastic left heart syndrome, comprising ductus arteriosus stenting and bilateral pulmonary artery banding, is a good surgical option for initial palliative procedure for high-risk patients for Norwood procedure. However, ductal stenting may cause retrograde aortic blood flow obstruction. Furthermore, complete removal of stent while performing the Norwood procedure make the operation more difficult. We report a case that overcame these problems using a novel surgical technique.
Impact of cyclones on manufacturing firms in India
Authors: Goldar Bishwanath , Goldar Amrita , Parida Yashobanta , Saini Atul 
Published: January 2025

Abstract
The impact of cyclones on assets and sales of manufacturing firms in India is examined econometrically using data on manufacturing companies for 2008–2019. We find that there is about a 4–6 per cent dip in sales and a 2–3 per cent dip in total assets of manufacturing firms following a cyclone incident in the district where the firms' plants are located. The fall in sales is bigger for relatively small-sized firms. For multi-plant firms with plants in different states, which are relatively bigger firms, the impact may be small or even negligible. By contrast, cyclones cause a fall in total assets for both big and small firms. The adverse effect of cyclones on sales and assets of manufacturing firms is relatively less for firms with a high trade-technology orientation. We also find that cyclones significantly raise the risk of business failure among manufacturing plants, more so among small plants.
Associate Psychological Practitioners (APPs) in primary care: modelling the impact
Authors: Lord Fiona , Budd Miranda , Gardner Kathryn Jane , Bhutani Gita , Nixon Debbie 
Published: January 2025

Abstract

Background:
The ‘Associate Psychological Practitioner’ (APP) is an innovative new role that expands the psychological workforce and addresses the rising demand for mental health services in England, yet the impact of this role on NHS workforce capacity has yet to be modelled.

Aim:
We modelled the impact of the APP role in Primary Care in terms of additional capacity to provide mental health care and the impact on General Practitioner (GP) capacity within the sector.

Method:
Workforce experts of the NHS Workforce Repository and Planning Tool (WRaPT) team used a modelling tool to determine future state scenarios of APPs working across all Primary Care Networks (PCNs) within a region and the associated change on the baseline workforce. Modelling was based on Lancashire and South Cumbria, a large geographical area in North-West England that includes 41 PCNs. Assumptions used in the modelling included identifying the patient population and workforce in scope, documenting the activity undertaken by APPs, and considering the future state scenarios for modelling.

Findings:
With regard to generating additional capacity, having 1 APP in each of the 41 PCNs in Lancashire and South Cumbria could provide 53 000 brief intervention appointments of 45 min each, thereby diverting these appointments away from the GP, and up to 48 people could benefit from attending Group and Well-being sessions over a year with 1 APP working with another Primary Care colleague, that is, 384 group intervention sessions delivered. In relation to GP capacity, 1 APP (if placed across a PCN, or within multiple practices) could free up at least 1,665 GP appointments within one year, which could lead to potential cost savings. These findings can be used to underpin decision-making with respect to training future cohorts of APPs and contribute to wider workforce planning in primary care.
Interspecific and intraspecific differences in seed germination response to different temperatures of three Echinochloa rice weeds: A case study with 327 populations
Authors: Chen Yang , Masoom Aatiqa , Huang Zeyue , Xue Jiahao , Chen Guoqi 
Published: January 2025

Abstract
Echinochloa crus-galli var. crus-galli (L.) P. Beauv. (EC), Echinochloa crus-galli var. mitis (Pursh) Petermann (ECM), and Echinochloa glabrescens Munro ex Hook. f. (EG) are all serious rice (Oryza sativa L.) weeds, which are usually treated as a single species in weed management practices. To determine interspecific and intraspecific differences in seed germination responding to different temperatures among the three Echinochloa weeds, we conducted field surveys and collected 66 EC, 141 ECM, and 120 EG populations from rice fields of East China in 2022; and tested their seed germination under 28/15C (day/night), 30/20C, and 35/25C regimes, simulating temperatures of rice planting periods for double-cropping early rice, single-cropping rice, and double-cropping late rice, respectively. In EC, ECM, and EG, seed percentage germination (cumulative percent of germinated seed) and germination index (sum of the ratio of germinated seeds to the corresponding days) increased with increasing temperatures. At 28/15C, the average percentage germination of EC populations (67.5%) was significantly (P < 0.05) higher than ECM (46.4%) and EG (43.7%); GD50 (duration for 50% total germination) for EC populations (5.2 d) was significantly shorter than ECM (5.9 d) and EG (5.8 d). At 35/25C, the percentage germination of EC (90.7%), ECM (80.5%), and EG (80.3%) were all significantly the highest among the three temperature treatments, respectively, and the GD50 values for EC (2.5 d), ECM (2.6 d), and EG (2.7 d) were all significantly the lowest. At 30/20C and 35/25C, average germination percentage of populations collected from transplanted rice fields were significantly higher than that of populations collected from direct-seeded rice fields. Moreover, among EG populations, the longitudes and latitudes of collection locations were significantly correlated with seed percentage germination and germination indices. According to the interspecific differences and intraspecific variations of Echinochloa species, weed management strategies should also be customized according to the species and population characteristics in seed germination.
Slowing Convergence Controls on Orogeny: A Three‐Stage Evolution of the Cenozoic India‐Asia Collision
Authors: Knight Ben S. , Capitanio Fabio A. , Weinberg Roberto F. , Dal Zilio Luca 
Published: January 2025

AbstractThe Cenozoic India‐Asia convergence represents the most well‐documented case of long‐lived orogeny, characterized by slowing plate convergence and complex deformation across the collisional margin, from crustal burial, exhumation and thrusting in the Himalaya, to thickening of southern Tibet. Here, we use a thermo‐mechanical computational model to show the controls of decelerating convergence on the lithospheric and orogenic structures during prolonged collision. Constant convergence velocity models, bracketing the India‐Asia convergence velocity, illustrate two rheological end‐members, a fast‐convergence orogeny dominated by lithospheric underthrusting and crustal burial and exhumation, and a slow convergence orogeny dominated by fold‐and‐thrusting and no lithospheric underthrusting. In contrast, models simulating the decelerating India‐Asia convergence history show a unique evolutionary path. The initial structures formed at fast convergence are subsequently destabilized as convergence decreases below ∼5 cm yr−1, and the structural style transitions from crustal burial and exhumation, and thickening to outwards compression along a frontal fold‐and‐thrust belt, progressively underthrusted by the subducting lithosphere. As the convergence decreases below ∼3 cm yr−1, the reduced compression cannot sustain the plateau height and crustal thickness, inducing collapse of the orogen interiors and the diapiric ascent of buried crust. These models show a three‐stage orogeny: fast thickening with crustal exhumation, widening along a frontal and fold‐and‐thrust belt, and internal collapse and extension. Similar to structuring of the Himalaya‐southern Tibet, with the early rise of the southern Tibetan Plateau to the Himalayan crystallines formation, to the later thrust belt expansion and internal doming, reconcile with the three‐stages orogeny, emphasizing the role of slowing convergence on orogenies.
A Fully Coupled Numerical Solution of Water, Vapor, Heat, and Water Stable Isotope Transport in Soil
Authors: Fu Han , Neil Eric John , Li Huijie , Si Bingcheng 
Published: January 2025

AbstractModeling water stable isotope transport in soil is crucial to sharpen our understanding of water cycles in terrestrial ecosystems. Although several models for soil water isotope transport have been developed, many rely on a semi‐coupled numerical approach, solving isotope transport only after obtaining solutions from water and heat transport equations. However, this approach may increase instability and errors of model. Here, we developed an algorithm that solves one‐dimensional water, heat, and isotope transport equations with a fully coupled method (MOIST). Our results showed that MOIST is more stable under various spatial and temporal discretization than semi‐coupled method and has good agreement with semi‐analytical solutions of isotope transport. We also validated MOIST with long‐term measurements from a lysimeter study under three scenarios with soil hydraulic parameters calibrated by HYDRUS‐1D in the first two scenarios and by MOIST in the last scenario. In scenario 1, MOIST showed an overall NSE, KGE, and MAE of simulated δ18O of 0.47, 0.58, and 0.92‰, respectively, compared to the 0.31, 0.60, and 1.00‰ from HYDRUS‐1D; In scenario 2, these indices of MOIST were 0.33, 0.52, and 1.04‰, respectively, compared to the 0.19, 0.58, and 1.15‰ from HYDRUS‐1D; In scenario 3, calibrated MOIST exhibited the highest NSE (0.48) and KGE (0.76), the smallest MAE (0.90) among all scenarios. These findings indicate MOIST has better performance in simulating water flow and isotope transport in simplified ecosystems than HYDRUS‐1D, suggesting the great potential of MOIST in furthering our understandings of ecohydrological processes in terrestrial ecosystems.
A Half‐Order Derivative Based Model of Lake Heat Storage Change
Authors: Liu Yuanbo , Tang Liangjun , Xing Wanqiu , Wang Jingfeng , Wang Ruonan , Cui Yifan , Li Qi 
Published: January 2025

AbstractHeat storage change (HSC) is a crucial component of lake's thermal energy budget. Conventional temperature profile based models of HSC require location specific parameters such as lakebed topography. Based on the half‐order time‐derivative formula of heat fluxes, an analytical model was formulated for estimating HSC from water surface temperature and solar radiation without using geography dependent parameters. The proposed model was tested against field measurements at Poyang Lake, a shallow inland lake, which has pronounced seasonal variations in water level and lake area. Our analysis indicates that the model accurately simulates diurnal HSC with a coefficient of determination of 0.94 and a root mean squared error (RMSE) of 77.5 ± 21.6 Wm−2 for the study period. Larger nighttime RMSE (75.0 ± 26.8 Wm−2) than the daytime value (55.1 ± 19.7 W m−2) is attributable to larger measurement errors of nighttime turbulent fluxes. The estimation of HSC independent of temperature profile and lake‐specific parameters by the proposed model facilitates remote sensing monitoring the HSC of global water bodies.
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion
Authors: Wang Jun , Xiao Nan , Zhu Zhengnong , Qiao Haiyan , Zhao Fang , Zhang Lukun , Gou Jizhou , Lu Mengji , He Yun , Lu Hongzhou , Li Qian 
Published: January 2025

AbstractEarly antiretroviral therapy (ART) initiation is known to limit the establishment of the HIV reservoir, with studies suggesting benefits such as a reduced number of infected cells and a smaller latent reservoir. However, the long-term impact of early ART initiation on the dynamics of the infected cell pool remains unclear, and clinical evidence directly comparing proviral integration site counts between early and late ART initiation is limited. In this study, we used Linear Target Amplification-PCR (LTA-PCR) and Next Generation Sequencing to compare unique integration site (UIS) clonal counts between individuals who initiated ART during acute HIV infection stage (Acute-ART group) and those in the AIDS stage (AIDS-ART group). Our analysis revealed distinct clonal distribution patterns, with greater UIS heterogeneity in Acute-ART group and more homogeneity in AIDS-ART group. Monoclonal UIS accumulation, predominantly in-gene regions, was influenced by ART timing and duration, with early treatment delaying this process. Host cell genes integrated by HIV provirus as monoclonal types were enriched in cell cycle and lymphocyte activation pathways. Tumor suppressor genes (TSGs) were more frequently integrated as monoclonal types in AIDS-ART group, suggesting potential risk factors. Overall, we introduced a sequencing method to assess provirus size in human peripheral blood and identified the widespread presence of monoclonal distribution of UIS in AIDS-ART group after long-term treatment. The early intervention helps slow the progress of clonal expansion of infected cells, reducing the formation of stable and persistent reservoirs, and ultimately posing fewer barriers to achieving a functional cure.
Clinical and radiographic evaluation of silver diamine fluoride versus mineral trioxide aggregate as indirect pulp capping agents in deeply carious first permanent molars a randomized clinical trial
Authors: Zaghloul Marwa Ahmed Ahmed , El Sayed Manal Ahmed , Abd Al-Gawad Randa Youssef , Abd El- Samad Ahmed Mohamed 
Published: January 2025

Abstract
Aim
Clinical and radiographic evaluation of SDF versus MTA as indirect pulp capping agents in deeply carious first permanent molars.

Methodology
This study was conducted on (30) first permanent molars indicated for indirect pulp capping (IPC) randomly allocated to either SDF or MTA groups (n = 15). The molars were finally restored with glass hybrid glass ionomer restoration. Clinical assessment was conducted at 3, 6, 9 and 12 months, while radiographic assessment was performed at 6 and 12 months using predetermined criteria. Data was statistically analyzed.

Results
There was no statistically significant difference between both groups for all assessed clinical and radiographic parameters, including dentin bridge formation, at all follow-up periods. There was no evidence of clinical or radiographic failure in either group.

Conclusions
SDF showed a high success rate compared to MTA and can be considered a promising alternative IPC agent in permanent molars.
Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib)
Authors: Chen Xiguang , Zeng Qiting , Yin Liyang , Yan Bingru , Wu Chen , Feng Jianbo , Wu Ying , He Jun , Ding Wenjun , Zhong Jing , Shen Yingying , Zu Xuyu 
Published: January 2025

Abstract
This research demonstrates that DCC-2036 (Rebastinib), a potent third-generation tyrosine kinase inhibitor (TKI), effectively suppresses tumor growth in colorectal cancer (CRC) models with functional immune systems. The findings underscore the capacity of DCC-2036 to enhance both the activation and cytotoxic functionality of CD8+ T cells, which are crucial for facilitating anti-tumor immune responses. Through comprehensive multi-omics investigations, significant shifts in both gene and protein expression profiles were detected, notably a marked decrease in DKK1 levels. This reduction in DKK1 was linked to diminished CD8+ T cell effectiveness, correlating with decreased FGR expression. Moreover, our findings identify FGR as a pivotal modulator that influences DKK1 expression via the PI3K-AKT-SP1 signaling cascade. Correlative analysis of clinical specimens supports the experimental data, showing that increased levels of FGR and DKK1 in CRC tissues are associated with inferior clinical outcomes and reduced efficacy of immunotherapeutic interventions. Consequently, targeting the FGR-AKT-SP1-DKK1 pathway with DCC-2036 could potentiate immunotherapy by enhancing CD8+ T cell functionality and their tumor infiltration. This strategy may contribute significantly to the refinement of therapeutic approaches for CRC, potentially improving patient prognoses.
A scaling law to model the effectiveness of identification techniques
Authors: Rocher Luc , Hendrickx Julien M. , Montjoye Yves-Alexandre de 
Published: January 2025

AbstractAI techniques are increasingly being used to identify individuals both offline and online. However, quantifying their effectiveness at scale and, by extension, the risks they pose remains a significant challenge. Here, we propose a two-parameter Bayesian model for exact matching techniques and derive an analytical expression for correctness (κ), the fraction of people accurately identified in a population. We then generalize the model to forecast how κ scales from small-scale experiments to the real world, for exact, sparse, and machine learning-based robust identification techniques. Despite having only two degrees of freedom, our method closely fits 476 correctness curves and strongly outperforms curve-fitting methods and entropy-based rules of thumb. Our work provides a principled framework for forecasting the privacy risks posed by identification techniques, while also supporting independent accountability efforts for AI-based biometric systems.
Distinct patterns of volcano deformation for hot and cold magmatic systems
Authors: Weber Gregor , Biggs Juliet , Annen Catherine 
Published: January 2025

AbstractVolcano deformation can be detected over timescales from seconds to decades, offering valuable insights for magma dynamics. However, these signals are shaped by the long-term evolution of magmatic systems, a coupling that remains poorly understood. Here we integrate thermal models of crustal-scale magmatism with thermo-mechanical simulations of ground deformation. This allows us to determine the influence of magmatic flux over 105–106 years on viscoelastic deformation spanning a 10-year observation period. Our results reveal a coupling between surface deformation and the thermal evolution of magma systems, modulated by magma flux and system lifespan. Relatively cold magma systems exhibit cycles of uplift and subsidence, while comparatively hot plumbing systems experience solely uplift. These findings align with geophysical observations from caldera systems, emphasizing the potential of surface deformation measurements as tool for deciphering the state and architecture of magmatic systems. Considering long-term magmatic system evolution is imperative for accurate interpretation of volcanic unrest.
New insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers
Authors: Ali Walaa A. , Moselhy Walaa A. , Ibrahim Marwa A. , Khalifa Ahlam G. , Mohamed Gadallah 
Published: January 2025

Abstract

Glutaraldehyde (GLU) is mainly used in medicine by healthcare workers during infection control as a chemical disinfectant. It has been linked to numerous health hazards that range from asthma to irritation of the eye to contact dermatitis. Citrullus colocynthis (C.C.) is utilized as a supplement to combat a range of health-related problems. This study aimed to assess the effectiveness of locally applied Citrullus colocynthis extract and Citrullus colocynthis loaded with ZnONPs against dermatitis caused by the disinfectant glutaraldehyde (2%).The female mice were divided into five groups (G1, G2, G3, G4, and G5). Group 1 was used as a control. The other 4 groups (2,3,4,and 5) were sprayed with 2% GLU (2 mg/kg body weight), and the other groups (3,4,and 5) were subjected to local application of natural products (Citrullus colocynthis extract cream, ZnONP cream, and Citrullus colocynthis loaded on ZnONP cream), respectively. Each experimental animal was followed for 5 days per week for 30 days.Our findings revealed that GLU-induced dermatitis via the upregulation of TNF-α, IL-1b, NFkb 1, and ptgs2 mRNA expression and the downregulation of TGFB1 mRNA expression caused oxidative stress and altered the biochemical markers and histological appearance. However, these effects were improved by the ZnONPs, C.C. extract, and C.C.-ZnONPs.Local application of Citrullus colocynthis ZnONPs and ZnONPs had preventive effects against GLU-induced dermatitis through the suppression of oxidative stress and inflammatory markers and the enhancement of antioxidants.