bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric Evaluation of Three-dimensional Conformal Radiotherapy, RapidArc, and Hybrid RapidArc Radiotherapy Techniques for Left-sided Breast Cancer
Authors: Mishra Atul , Yadav Neha , Sharma Madhu , Mittal Kailash Kumar , Mishra Surendra Prasad , Verma Teerth Raj , Tiwari Shilpa 
Published: February 2025

Abstract

Objective:
This study aimed to assess the irradiation techniques–three-dimensional conformal radiotherapy (3DCRT), RapidArc (RArc), and hybrid RapidArc (h-RArc)–for left-sided breast cancer patients, focusing on dose distribution in the planning target volume (PTV) and organs at risks (OARs).

Materials and Methods:
This study enrolled 20 patients diagnosed with early-stage left-sided breast cancer. All patients received a prescribed dose of 40.05 Gy in 15 fractions (2.67 Gy per fraction), optimized to achieve 95% dose coverage to 95% of the PTV. The dosimetric variations across the three treatment plans for the 20 patients were examined using a one-way ANOVA test. P <0.05 was regarded as statistically significant.

Results:
In the 3DRCT plan, D95% of the PTV was 37.21 ± 0.51 Gy. This value was significantly increased to 39.43 ± 0.27 Gy in the RArc plan (P = 0.001) and to 38.47 ± 0.19 Gy in the h-RArc plan (P = 0.630). The RArc plans demonstrated a superior homogeneity index of 0.12 ± 0.02 compared to both 3DCRT (0.18 ± 0.02) and h-RArc (0.13 ± 0.02). When comparing the increase in monitor units (MUs), h-RArc showed a 62.82% increase over 3D-CRT, whereas demonstrating a 38.05% decrease compared to RArc (P = 0.000).

Conclusions:
h-RArc treatment plans for breast cancer may be recommended due to their superior and consistent PTV dose coverage and sparing of OARs, in comparison to both 3DRCT and RArc plans. These h-RArc plans are characterized by reduced MU and beam on time, as well as a less low volume dose when compared to RArc plans.
Diagnostic Accuracy of Cone-Beam Computed Tomography (CBCT) in Identifying Periapical Lesions: A Comparative Study with Conventional Radiography
Authors: Kanneppady Sowmy S. , Kanneppady Sham K. , Mathew Tony , Almazrou Yaser M. , Syed Afroz K. , Hota Sadananda , Tiwari Rahul 
Published: February 2025

ABSTRACT

Introduction:
Periapical lesions are a common clinical finding, often detected through imaging techniques such as conventional radiography (CR) and cone-beam computed tomography (CBCT). This study aims to compare the diagnostic accuracy of CBCT with CR in identifying periapical lesions.

Methods:
This comparative study involved patients undergoing dental treatment. Each patient received both CBCT and conventional radiography for periapical lesion detection. The diagnostic outcomes of both modalities were evaluated based on lesion size, position, and diagnostic clarity. Statistical analysis was conducted to compare the sensitivity, specificity, and accuracy of CBCT and CR.

Results:
CBCT demonstrated superior diagnostic accuracy compared to CR in detecting periapical lesions. The average sensitivity and specificity of CBCT were higher, particularly in detecting smaller and more complex lesions. Statistical analysis showed a significant difference between CBCT and CR in lesion detection (P < 0.05).

Conclusion:
CBCT is a more reliable imaging modality for the detection of periapical lesions compared to conventional radiography, offering higher diagnostic accuracy. Further studies are needed to establish CBCT as a standard diagnostic tool in clinical practice.
Assessment of Jaw Bone Density Using Cone-Beam CT in Patients with Osteoporosis: A Cross-Sectional Study
Authors: Kanneppady Sowmy S. , Kanneppady Sham K. , Jamatia Kahamnuk , Tiwari Kumudhati , Ausare Surabhi S. , Dash Ayushi , Syed Afroz K. 
Published: February 2025

ABSTRACT

Introduction:
Osteoporosis is a systemic condition characterized by reduced bone mineral density (BMD), leading to increased fracture risk. Assessing jaw bone density is vital for early detection and treatment planning, especially in dental and maxillofacial contexts. Cone-beam computed tomography (CBCT) has emerged as an essential tool for evaluating bone quality in osteoporotic patients.

Methods:
This cross-sectional study assessed jaw bone density in osteoporotic patients using CBCT. A total of 100 patients, aged 45–75, were included. BMD was calculated using CBCT-derived Hounsfield Units (HU), and results were correlated with dual-energy X-ray absorptiometry (DXA) data. Parameters included mandibular cortical width, trabecular bone structure, and radiomorphometric indices.

Results:
CBCT revealed a significant correlation between HU values and DXA scores (P < 0.05). Mandibular cortical width and trabecular structure alterations were observed in osteoporotic patients. Two tables present the statistical data on the correlations between HU values and DXA measurements.

Conclusion:
CBCT offers a reliable method for assessing jaw bone density in osteoporotic patients. Its ability to detect low bone density could enhance early diagnosis and improve clinical outcomes.
Correlation between Histopathological Features and Clinical Outcomes in Patients with Oral Squamous Cell Carcinoma
Authors: Tiwari Shamita , Shekhar Saurabh , Ramanand Oruganti V. , Mishra Pallavi , Nelson Anish , Shankar Kiran S. , Mathur Riddhima 
Published: February 2025

ABSTRACT

Introduction:
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy, with histopathological features playing a crucial role in predicting clinical outcomes. Tumor budding, lymphovascular invasion, and depth of invasion are key indicators used to assess prognosis and therapeutic response. The objective of this research is to examine the correlation between these histopathological parameters and patient outcomes.

Methods:
This retrospective analysis included patients diagnosed with OSCC. The key parameters examined were tumor budding, depth of invasion, and lymphovascular invasion. Clinical outcomes, including recurrence and survival rates, were analyzed.

Results:
Tumor budding and depth of invasion were significantly associated with increased recurrence rates and poorer survival outcomes. Lymphovascular invasion also showed a strong correlation with advanced disease stages.

Conclusion:
The histopathological features, particularly tumor budding and depth of invasion, are significant predictors of clinical outcomes in OSCC patients. These features should be emphasized in the prognosis and treatment planning of OSCC.
Anterior Rehabilitation with Basal Implants in Cleft Cases Systematic Review
Authors: Patel Nirav , Jha Kunal , Pavethynath Velusamy , Ravi Sindhura , Pendyala Siva K. , Shinde Samidha M. , Tiwari Rahul 
Published: February 2025

ABSTRACT

Objective:
To carefully examine the literature on anterior rehabilitation with basal implants in cleft patients, including clinical outcomes, success rates, and complications.

Methods:
A PubMed search was extensive for published research. The inclusion criteria were original research studies on basal implants in anterior cleft rehabilitation, including clinical outcomes, success rates, and complications, with a minimum follow-up period of 6 months. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Analytical Cross-Sectional Studies assessed the quality of the included studies after data were retrieved and synthesized using a standard form.

Results:
The review identified four papers that matched the criteria. The trials examined clinical and surgical care, two-stage implant surgery results, and orthodontic treatment with bone grafting and implant implantation. Infection, complication, and success rates were examined across trials.

Conclusion:
The included trials found 100% success with anterior rehabilitation with basal implants for cleft lip and palate. This method is safe and feasible because no infections or problems have been documented. Basal implants in cleft instances should be tested for long-term efficacy, safety, and patient satisfaction in well-designed clinical trials.
Assess the Role of Cognitive Behavioral Therapy in Improvement of Pain and Quality of Life in Patients with Chronic Low Backache
Authors: Mehta Harry , Singla Karanveer , Mahajan Anupam , Singh Noel S. , Sood Rewa 
Published: February 2025

ABSTRACT

Background:
Most frequent concerns among patients who attend orthopaedic centres is chronic low back pain.

Material and Methods:
Study aimed to compare effectiveness of psychological counselling in addition to standard medical care for patients with chronic low back pain by measuring their improvement with the Visual Analogue Scale (VAS), the 36-Item Short Form Survey (SF-36), the Oswestry Disability Index (ODI) and the Hospital Anxiety and Depression Scale (HADS). Comparing Groups A and B at 6 and 12 weeks on the VAS measure.

Results:
Group A demonstrated 25% and 29% improvement, while for Group B, it was 18% and 20% respectively. At 6 and 12 weeks, the SF-36 measure revealed 13% and 17% improvement in Group A, compared to 5% and 10% in Group B, respectively. At 6 and 12 weeks, the ODI indicated 12% and 18% improvement in Group A versus 9% and 13% in Group B, respectively. Additionally, Group A significantly outperformed Group B in terms of the HADS.

Conclusion:
We concluded psychological counselling in addition to the regular standard of care produces superior outcomes compared to regular standard of care alone.
Differential plasticity of excitatory and inhibitory reticulospinal fibers after spinal cord injury: implication for recovery
Authors: Jeleva Rozaria , Muhr Carmen Denecke , Liebisch Alina P. , Bareyre Florence M. 
Published: February 2025

Abstract
The remodeling of axonal connections following injury is an important feature driving functional recovery. The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory fibers. While the reticulospinal tract has been shown to be particularly prone to axonal growth and plasticity following injuries of the spinal cord, the differential capacities of excitatory and inhibitory fibers for plasticity remain unclear. As adaptive axonal plasticity involves a sophisticated interplay between excitatory and inhibitory input, we investigated in this study the plastic potential of glutamatergic (vGlut2) and GABAergic (vGat) fibers originating from the gigantocellular nucleus and the lateral paragigantocellular nucleus, two nuclei important for locomotor function. Using a combination of viral tracing, chemogenetic silencing, and AI-based kinematic analysis, we investigated plasticity and its impact on functional recovery within the first 3 weeks following injury, a period prone to neuronal remodeling. We demonstrate that, in this time frame, while vGlut2-positive fibers within the gigantocellular and lateral paragigantocellular nuclei rewire significantly following cervical spinal cord injury, vGat-positive fibers are rather unresponsive to injury. We also show that the acute silencing of excitatory axonal fibers which rewire in response to lesions of the spinal cord triggers a worsening of the functional recovery. Using kinematic analysis, we also pinpoint the locomotion features associated with the gigantocellular nucleus or lateral paragigantocellular nucleus during functional recovery. Overall, our study increases the understanding of the role of the gigantocellular and lateral paragigantocellular nuclei during functional recovery following spinal cord injury.
Canalicular repair in an infant with a simple modification in implantation technique of a conventional innovative implant for canalicular stenting
Authors: Sharma Vikas , Waghray Ritesh , Singh Anuradha , Bhatia Agrima , Sahu Akanksha , Kalra Nidhi , Patnaik Subhasish 
Published: February 2025

Abstract
Eyelid injuries associated with canalicular rupture may lead to lacrimal drainage obstruction if not repaired in time. Of the various techniques available, monocanalicular stenting is the procedure of choice. However, these stents are not only costly but also their availability is a limitation. Majority literature focuses on innovative techniques to identify the lost medial part of canaliculi. We developed a novel surgical technique for canalicular repair by inserting a 26 gauge plastic sleeve of pediatric Intravenous cannula utilizing 27 gauge metal irrigation cannula as a guiding tool.
Upaya Meningkatkan Kemampuan Motorik melalui Pendekatan Permainan pada Peserta Didik Kelas Bawah Sekolah Dasar
Authors: Ardianto Ach Aris Eko , Kuntjoro Bambang Ferianto Tjahyo , Makung Yohanes Giovani Pion 
Published: February 2025

Based on the research objectives by looking at the impact of a game approach in improving the motor skills of students, class action research as a method used by using several stages of implementation, the subject in the study with lower grade students of Putat Gede I/94 Surabaya public elementary school, the instrument uses a motor skill test with agility, coordination, balance and speed. Data obtained and analysed by descriptive with percentage. The results of the study at each stage of the pre-siklus (18.52%), siklus I (37.04%),siklus II (74.07%). That way it can be seen that there is an increase at each stage based on the concept of completeness criteria, so it can be concluded that there is an increase in motor skills through the game approach in students.
Bolavoli : Latihan Ball Drop Drill untuk Meningkatkan Keterampilan Pasing Bawah
Authors: Sari Eka Novita , Irwanto Edi , Triaiditya Bayu Septa Martaviano , Santoso Danang Ari 
Published: February 2025

This research aims to determine the effect of ball drop drill training on improving the bottom passing skills of female volleyball athletes at SMAN 1 Tegaldlimo. This research uses experimental methods. The sample in this research consisted of 8 students. The technique for collecting data on fitting skills uses AAHPERD TEST tests and measurements. The data analysis technique uses SPSS 25. The results of the research show that there is a significant increase in bottom fitting skills by using ball drop drill training at 0.001 < 0.05. This means that this exercise can be used to improve volleyball bottom passing skills.
Investigating the Impact of Entrepreneurial Orientation on Supply Chain Performance: The Moderating Role of Project Management Competence
Authors: Tarawneh Heba Akram , Sharayah Qusay Mikhled , Sharayah Oday Mikhled 
Published: February 2025

Objective: the objective of this study is to address the gap in understanding the dynamics related to entrepreneurial orientation, supply chain performance, and the moderating role of project management competence, which provides a base for further exploration and broader practical implementation in the field.

Theoretical Framework: Research into the expression of Entrepreneurial Orientation (EO) affecting Supply Chain Performance (SCP) is critically important to a range of Jordanian industrial establishments, as it highlights the strategic role of innovative and proactive action in the pursuit of operational efficiency.

Method: The population for this study consists of administrative and operational employees working in Jordanian industrial companies. A representative sample of 380 respondents was determined. To evaluate the collected data, the study utilized SmartPLS-4, a statistical software tool suitable for structural equation modeling (SEM).

Results and Discussion: The study found that there is moderating role of project management competence on the impact of entrepreneurial orientation on supply chain performance. Jordanian industrial companies are recommended to create an employment culture that promotes creativity, risk and proactivity among industrial workforces of the group.

Research Implications: This can be carried out by using training sessions, workshops, and incentive mechanisms that promote creativity and calculated risks. It is necessary for organizations to dedicate resources to developing project management abilities within their teams.

Originality/Value: Research into the expression of Entrepreneurial Orientation (EO) affecting Supply Chain Performance (SCP) is critically important to a range of Jordanian industrial establishments, as it highlights the strategic role of innovative and proactive action in the pursuit of operational efficiency.
Crafting Strategy, Making Continuum Peace? A Proposal of Social Practice Peacebuilding Research
Authors: Sunarti  , Nurdin Muhamad Fadhil , Sekarningrum Bintarsih , Nulhaqim Soni Akhmad 
Published: February 2025

Objective: The study assesses postconflict peacebuilding's analytical and political potential. Bourdieu's social practices and peacebuilding ideas show that long-term peace requires integration. We examined Sendoreng, Monterado District, Bengkayang Regency, West Kalimantan to see if local peace initiatives promote reconciliation.

Theoretical Framework: Bourdieu's social practices and peacebuilding theories are used to study post-conflict reconciliation. Subjectivity, collective memory, and how individual and communal experiences affect peace processes are stressed. The paradigm emphasises local traditions in peacebuilding and how social structures and identity narratives affect conflict and negotiation..

Method: The study used a narrative approach to show conflict's emotional effects and lived experiences, enhancing postconflict perspectives. Qualitative analysis helps synthesise data for historical views and peacebuilding tactics.

Results and Discussion: Intergroup conflicts caused by social culture and ethnic prejudices have shaped Sendoreng's conflict history, according to the data. Social cohesion and local culture foster Dayak-Maduru transformation. Postconflict integration uses institutional and community-driven regional forums and social normalization.

Research Implications: To guarantee lasting reconciliation, the research proposes peacebuilding tactics include participatory decision-making and stakeholder engagement. It emphasizes the role of legal systems, national harmony forums, and policy frameworks in ethnic peacekeeping. A systematic dispute resolution strategy from the research benefits lawmakers and peacekeepers across sociocultural contexts.

Originality/Value: This study applies Bourdieu's social practices theory to post-conflict reconciliation, providing a new viewpoint on peacebuilding. It uses Sendoreng as a unique case study to show how local culture affects conflict settlement. Peacebuilding research and practice can benefit from the paper's integrated conflict management model, which includes social, institutional, and policy initiatives.
Análisis de los motivos de práctica en la actividad física dirigida
Authors: Picó-Martínez Fernando , Fuentes Juan Pedro , Martínez-Gallego Rafael 
Published: February 2025

Introducción: La motivación supone un factor psicológico que determina la adherencia en el ejercicio físico, por lo que su análisis dentro de los diferentes tipos de actividades dirigidas (AADD) puede proporcionar herramientas útiles a los centros deportivos de cara a brindar una mejor experiencia al practicante.
Objetivo: Así pues, el objetivo del estudio fue analizar los motivos de práctica en aquellos practicantes de AADD, observándose las diferencias en la motivación respecto al género, la edad y el tipo de AADD.
Metodología: Se empleó una muestra de 291 practicantes de actividad física dirigida (227 mujeres y 64 hombres), con edades comprendidas entre los 17 y los 82 años, siendo la media de edad de 42,79 ± 16,02 años. Las variables analizadas fueron los motivos de práctica (administrando el cuestionario MPAM-R).
Resultados: Tras el análisis, los resultados revelaron que existían diferencias significativas en los motivos de práctica en función del género, la edad y el tipo de AADD. La apariencia (AP) fue un motivo más importante para aquellos que practicaban AADD del tipo fuerza (FZ), cardiorrespiratioria (CR) y multiactividad (MA), además de hombres y jóvenes.
Discusión: Por ello, se debe buscar un enfoque del entrenamiento basado en los motivos por los que los practicantes escogen un determinado tipo de AADD.
Conclusiones: Los motivos de práctica, especialmente competencia (CP) y AP, son más relevantes para hombres y jóvenes. Futuros estudios deben abordar estas variables en entornos homogéneos y con un diseño longitudinal para establecer relaciones causales.
Nanotubos de Titanatos Conjugados com Cisplatina: Um Sistema Carreador para Liberação controlada de Fármacos Antineoplásicos
Authors: Souza B. C. , Marinkovic B. , Perina S. 
Published: February 2025

A cisplatina é um agente antineoplásico amplamente utilizado no tratamento de diversos tipos de câncer. Mas devido a sua toxicidade, sua dose máxima diminui seu efeito terapêutico. Diversos sistemas carreadores têm sido propostos para reduzir sua toxicidade sistêmica. A encapsulação em nanotubos de titânio protege o fármaco da degradação no ambiente biológico, neste aspecto as formulações em nano-escala justificam-se por serem promissoras permitindo maior performance da droga. Há uma diversa gama de fármacos potentes com propriedades físico-químicas, farmacológicas e toxicológicas que dificultam sua utilização clínica. Algumas destas propriedades relacionadas à droga matriz fundamentam a necessidade de modificar algumas das propriedades destas moléculas, tais como: biodisponibilidade, efeitos tóxicos e/ou incapacidade de atravessar diversos tipos de barreiras biológicas. Os nanotubos de titanatos são dotados de características físico-químicas únicas como uma elevada estabilidade e biocompatibilidade, o que proporciona a estes uma grande vantagem na utilização na terapia do câncer, posto que é capaz de se ligar ao princípio ativo do medicamento sem interferir no meio onde ocorre a ação medicamentosa. Tem-se como objetivos dessa pesquisa desenvolver uma metodologia para conjugar nanotubos de titanatos ao pró-fármaco cisplatina, determinar as características de ligação da cisplatina sobre a superfície de nanotubos, a caracterização físico-química do material conjugado obtido além de comparar a eficácia do conjugado Nanotubos+Cisplatina com a cisplatina pura in vitro e analisar sua ação sobre as células cancerígenas da linhagem HeLa. Está sendo realizada em 3 etapas: na 1ª etapa foi realizada a síntese hidrotérmica dos nanotubos de titanato que serão utilizados como veiculo para carreamento do fármaco; na 2ª etapa que ainda está sendo desenvolvida, será investigada a interação físico-química da Cisplatina+Nanotubos, para isso serão utilizadas análises térmicas (TG, DSC) e Espectrometria de IV e na 3ª e última etapa serão realizados os testes in vitro por meio do ensaio MTT colorimétrico, que permitirá o cálculo do IC50 do sistema obtido. O desenvolvimento de nanopartículas para o transporte eficaz de fármacos com um novo sistema carreador (drug delivery) para a droga cisplatina até as células tumorais surge como uma técnica inovadora para terapia do câncer podendo gerar novas patentes e melhorar o desempenho de drogas já conhecidas aumentando seu índice terapêutico utilizando menos fármaco.