bluuebunny/crossref_metadata_2025_split huggingface dataset:
A wavefield reconstruction method using sparse representation and dictionary learning for RTM
Authors: Pei Chunyang , Shi Linge , Li Shiheng , Zhou Xiaohua , Long Yun , Chen Zubin 
Published: August 2023

Abstract
Reverse time migration (RTM) is a well-established imaging technique that uses the two-way wave equation to achieve high-resolution imaging of complex subsurface media. However, when using RTM for reverse time extrapolation, a source wavefield needs to be stored for cross-correlation with the backward wavefield. This requirement results in a significant storage burden on computer memory. This paper introduces a wavefield reconstruction method that combines sparse representation to compress a substantial amount of crucial information in the source wavefield. The method uses the K-SVD algorithm to train an adaptive dictionary, learned from a training dataset consisting of wavefield image patches. For each timestep, the source wavefield is divided into image patches, which are then transformed into a series of sparse coefficients using the trained dictionary via the batch-orthogonal matching pursuit algorithm, known for its accelerated sparse coding process. This novel method essentially attempts to transform the wavefield domain into the sparse domain to reduce the storage burden. We used several evaluation metrics to explore the impact of parameters on performance. We conducted numerical experiments using acoustic RTM and compared two RTM methods using checkpointing techniques with two strategies from our proposed method. Additionally, we extended the application of our method to elastic RTM. The conducted tests demonstrate that the method proposed in this paper can efficiently compress wavefield data, while considering both computational efficiency and reconstruction accuracy.
The impact of osteosarcopenia in patients with unresectable or recurrent biliary tract cancer receiving palliative chemotherapy
Authors: Takeda Tsuyoshi , Okamoto Takeshi , Sasaki Takashi , Hirai Tatsuki , Ishitsuka Takahiro , Yamada Manabu , Nakagawa Hiroki , Mie Takafumi , Furukawa Takaaki , Kasuga Akiyoshi , Ozaka Masato , Sasahira Naoki 
Published: August 2023

Abstract

Background
Osteosarcopenia is a newly described syndrome that has been reported to be associated with worse outcomes in various types of cancer. However, its impact on survival in biliary tract cancer remains unclear. This study evaluated the impact of osteosarcopenia on survival in patients with unresectable or recurrent biliary tract cancer.

Methods
A total of 306 patients with unresectable or recurrent biliary tract cancer who initiated chemotherapy at our institution between 2015 and 2021 were retrospectively investigated. Skeletal muscle index and bone mineral density were measured using pretreatment cross-sectional computed tomography images. Baseline characteristics and survival outcomes were compared between patients with osteosarcopenia and those without. The Cox proportional hazards regression model was used to identify factors associated with survival.

Results
Osteosarcopenia was present in 66 patients (22%) and was associated with older age (74 vs. 69 years, P &lt; 0.001) and female sex (58 vs. 37%, P = 0.003). Patients with osteosarcopenia tended to have worse performance status (P = 0.098), higher modified Glasgow prognostic score (P = 0.082), higher neutrophil to lymphocyte ratio (P = 0.058) and were significantly less likely to receive combination chemotherapy (68 vs. 80%, P = 0.044) than those without. Osteosarcopenia was associated with reduced survival (8.9 vs. 14.0 months, P &lt; 0.001) and was identified as an independent factor predicting shorter survival in multivariate analysis.

Conclusions
Osteosarcopenia was associated with poor survival in unresectable or recurrent biliary tract cancer treated with chemotherapy. This study highlights the potential importance of screening for osteosarcopenia in patients with biliary tract cancer.
Proliferation of monocytes and macrophages in homeostasis, infection, injury, and disease
Authors: Pang Jingbo , Koh Timothy J 
Published: August 2023

AbstractMonocytes (Mo) and macrophages (Mφ) play important roles in the function of tissues, organs, and systems of all animals during homeostasis, infection, injury, and disease. For decades, conventional wisdom has dictated that Mo and Mφ are end-stage cells that do not proliferate and that Mφ accumulation in tissues is the result of infiltration of Mo from the blood and subsequent differentiation to Mφ. However, reports from the early 1900s to the present describe evidence of Mo and Mφ proliferation in different tissues and contexts. The purpose of this review is to summarize both historical and current evidence for the contribution of Mφ proliferation to their accumulation in different tissues during homeostasis, infection, injury, and disease. Mφ proliferate in different organs and tissues, including skin, peritoneum, lung, heart, aorta, kidney, liver, pancreas, brain, spinal cord, eye, adipose tissue, and uterus, and in different species including mouse, rat, rabbit, and human. Mφ can proliferate at different stages of differentiation with infiltrating Mo-like cells proliferating in certain inflammatory contexts (e.g. skin wounding, kidney injury, bladder and liver infection) and mature resident Mφ proliferating in other inflammatory contexts (e.g. nematode infection, acetaminophen liver injury) and during homeostasis. The pathways involved in stimulating Mφ proliferation also may be context dependent, with different cytokines and transcription factors implicated in different studies. Although Mφ are known to proliferate in health, injury, and disease, much remains to be learned about the regulation of Mφ proliferation in different contexts and its impact on the homeostasis, injury, and repair of different organs and tissues.
A study of Anopheles monticola of the Baileyi Complex, Culex sasai, and Lutzia vorax (Diptera: Culicidae) in Yunnan Province, China
Authors: Zhou Li , Phanitchakun Thanari , Saingamsook Jassada , Harbach Ralph E , Somboon Pradya 
Published: August 2023

Abstract
This article deals with the morphological and molecular assessments of 3 species of mosquitoes collected in Yunnan Province, China, i.e Anopheles monticola Somboon, Namgay & Harbach, the only species of the Baileyi Complex identified, Culex sasai Kano, Nitahara & Awaya, and Lutzia vorax Edwards. Interestingly, some adult specimens of An. monticola exhibited a variant form in having pale fringe spots, as found in An. simlensis James, another species of the Baileyi Complex. Culex sasai was recorded for the first time in Yunnan and mainland China. The prevalence of Lt. vorax was confirmed, and previous records of Lt. halifaxii in China are regarded as misidentifications of Lt. vorax.
Governance Interrupted: Rebel Governance and Pro-Government Militias
Authors: Joo Minnie M , Sosa Santiago 
Published: August 2023

Abstract
Despite the benefits of rebel governance such as increased legitimacy and resource extraction, providing governance is also costly for rebel groups, as it entails constant investment of time and money as well as the need to protect their properties and territories. Rebels, therefore, weigh the costs of providing governance against the benefits in their decision to provide governance. In this paper, we explore the impact of pro-government militias (PGMs) on the cost-benefit analysis of rebel governance. We argue that governance becomes a suboptimal strategy for rebel groups in the presence of semi-official PGMs but not informal PGMs. This is because semi-official PGMs’ relationship with the government makes them more formally accountable to the government, which effectively bolsters the counterinsurgency capabilities of the state (and thereby weakens rebels) through providing credible and timely intelligence and undermining civilians support for the rebels, and even allowing rebel defection. We test our argument using data on rebel governance and PGMs and indeed find that semi-official—but not informal—PGMs decrease the likelihood of rebel governance.
Retained surgical item in inguinal canal of a patient with bilateral inguinal hernia: a case report
Authors: Mabrouk Ola , Ibrahim Khalid 
Published: August 2023

Abstract
Retained surgical items that remain inside patient’s body during operation are linked to increased mortality, morbidity and negative financial consequences. This case reports a 65-year’s-old male nurse with bilateral inguinal swelling. With history of right sided inguinal hernia 8 years ago that underwent open repair without mesh. Swelling was reducible on right side only, positive visible and palpable cough impulse bilaterally, and surgical scar on right iliac region. Diagnosed as left side inguinal hernia with recurrent right side inguinal hernia. After informed consent and preoperative assessment, open repair started with right side, sac excised after reducing content and mesh placed. Same procedure done on left, surgical gauze was found in inguinal canal and removed successfully, operation completed. Patient did well on follow-up. Collaboration and communication is crucial between staff during operations to prevent errors and promote safety.
A late presentation of inguinoscrotal cutaneous squamous cell carcinoma (cSCC) masquerading as hidradenitis suppurativa—a case report
Authors: Lahham Elias Edward , Billan Salem , Atrash Fadi , Fararja Walid 
Published: August 2023

Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects apocrine gland-bearing skin in intertriginous areas; it is characterized by persistent or recurrent abscesses that culminate in a purulent discharge, sinuses and scarring. Although it is a common condition, it is rarely associated with cutaneous squamous cell carcinoma (cSCC). Whereas the female-to-male ratio of HS is 3:1, SCC in HS has a female-to-male ratio of 1:5. In this study, we present a 50-year-old male patient with a late presentation of inguinoscrotal cSCC with extensive ulceration and erythema that was hidden by neglected HS and the presence of underlying human papillomavirus in the affected area. The histomorphologic and immunohistochemical findings support the diagnosis of cSCC. Timely detection is the key to improve prognosis, regular clinical examination and biopsy of any suspicious lesions in high-risk patients is highly recommended.
Variable Inclusion Strategies for Effective Quota Sampling and Propensity Modeling: An Application to SARS-CoV-2 Infection Prevalence Estimation
Authors: Li Yan , Fay Michael , Hunsberger Sally , Graubard Barry I 
Published: August 2023

Abstract
Public health policymakers must make crucial decisions rapidly during a pandemic. In such situations, accurate measurements from health surveys are essential. As a consequence of limited time and resource constraints, it may be infeasible to implement a probability-based sample that yields high response rates. An alternative approach is to select a quota sample from a large pool of volunteers, with the quota sample selection based on the census distributions of available—often demographic—variables, also known as quota variables. In practice, however, census data may only contain a subset of the required predictor variables. Thus, the realized quota sample can be adjusted by propensity score pseudoweighting using a “reference” probability-based survey that contains more predictor variables. Motivated by the SARS-CoV-2 serosurvey (a quota sample conducted in 2020 by the National Institutes of Health), we identify the condition under which the quota variables can be ignored in constructing the propensity model but still produce nearly unbiased estimation of population means. We conduct limited simulations to evaluate the bias and variance reduction properties of alternative weighting strategies for quota sample estimates under three propensity models that account for varying sets of predictors and degrees of correlation among the predictor sets and then apply our findings to the empirical data.
Sexuality experiences of women with multiple sclerosis reporting overactive bladder: a qualitative study
Authors: Dunya Cansu Polat , Özkan İlknur , Demir Serkan 
Published: August 2023

Abstract

Background
To effectively manage sexual dysfunction in women reporting overactive bladder, it is essential to know how patients perceive these problems, their lives, and their strategies.

Aim
In this study we aimed to understand the sexual life experiences of women with multiple sclerosis (MS) who report overactive bladder from their point of view.

Methods
This study included 12 women with MS and was conducted as a qualitative study with a hermeneutic phenomenological framework. The data were evaluated by using Van Manen’s thematic analysis method. The Consolidated Criteria for Reporting Qualitative Research checklist was used.

Outcomes
In this study, thematic codes of sexual symptoms in women with MS with overactive bladder were defined and evaluated.

Results
As a result of the analysis of the data, four main themes and nine subthemes were identified. The main themes were “sexual self-concept,” “sexual relationships,” “sexual function,” and “coping with problems”. Subthemes such as body image, sexual esteem, the meaning of sexuality, communication, intimacy, coping with overactive bladder and sexual problems, and getting support showed that overactive bladder symptoms negatively affected women’s sexual health.

Clinical Implications
Given the variety of sexual problems experienced by women with MS who report overactive bladder, these problems should be a routine part of clinical evaluation.

Strengths and Limitations
This study is to our knowledge the first to examine the sexual life experiences of MS women reporting overactive bladder in depth based on the holistic view of sexuality theory. However, the sample is small and includes only women with MS who have reported overactive bladder.

Conclusions
The sexual experience of women with MS who reported overactive bladder was multi-dimensional. Women with MS cope with their sexual problems alone and cannot receive the necessary support from their husbands, nurses, or other health professionals.
Travel-related giardiasis: incidence and time trends for various destination countries
Authors: Hommes Franziska , Dörre Achim , Behnke Susanne C , Stark Klaus , Faber Mirko 
Published: August 2023

Abstract

Background
Giardiasis is a common gastrointestinal illness in travellers. Data on the actual giardiasis risk of travellers to different travel destinations are scarce. We aim to estimate the risk of giardiasis in travellers from Germany by destination country and region.

Methods
We analysed travel-related giardiasis cases, their countries and regions of exposure and the age and sex distribution of cases reported in 2014–19 in Germany. We defined a travel-related giardiasis case as a laboratory-confirmed (i.e. positive microscopy, antigen test or nucleic acid test) symptomatic individual with outbound travel abroad within 3–25 days before symptom onset. Based on the number of reported cases per exposure country and UNWTO travel data for Germany, we calculated the number of travel-related giardiasis cases per 100 000 travellers and compared the incidence in 2014–16 and 2017–19 to identify potential trends.

Results
In 2014–19, 21 172 giardiasis cases were reported in Germany, corresponding to an overall incidence of 4.3 per 100 000 population. Of all cases, 6879 (32%) were travel-related with a median age of 34 [interquartile range (IQR): 25–50], 51% were male. Southern Asia was the most frequently reported exposure region and had the highest incidence in travellers (64.1 per 100 000 returning travellers) in 2017–19, followed by Latin America (19.2) and Sub-Saharan Africa (12.9). We observed statistically significant decreasing trends for Southern Asia and Sub-Saharan Africa. Latin America was the only region with a statistically significant increasing trend.

Conclusions
Almost one-third of recent giardiasis cases in Germany were travel-related. Giardiasis incidence in travellers differs greatly depending on the destination region. Decreasing trends in many regions might be due to improvements in food hygiene or travel conditions. Our results may inform medical consultation pre and post patient’s travel.
The transcription factor EMB1444-like affects tomato fruit ripening by regulating YELLOW-FRUITED TOMATO 1, a core component of ethylene signaling transduction
Authors: Zhao Weihua , Wang Shan , Li Wenzhen , Shan Xuemeng , Naeem Muhammad , Zhang Lida , Zhao Lingxia 
Published: August 2023

Abstract
The fleshy fruit of tomato (Solanum lycopersicum) are climacteric and, as such, ethylene plays a pivotal role in their ripening and quality traits. In this study, a basic helix–loop–helix transcription factor, EMB1444-like, was found to induce the expression of YELLOW-FRUITED TOMATO 1 (YFT1), which encodes the SlEIN2 protein, a key element in the ethylene signaling pathway. Yeast one-hybrid and EMSA analyses revealed that EMB1444-like binds to the E-box motif (CACTTG, –1295 bp to –1290 bp upstream of the ATG start codon) of the YFT1 promoter (pYFT1). Suppression of EMB1444-like expression in tomato lines (sledl) using RNAi reduced ethylene production by lowering the expression of 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2/4 (ACS2/4) and ACC OXIDASE1 (ACO1) in a positive feedback loop. sledl tomato also showed differences in numerous quality traits related to fruit ripening, compared with the wild type, such as delayed chromoplast differentiation, a decrease in carotenoid accumulation, and delayed fruit ripening in an ethylene-independent manner, or at least upstream of ripening mediated by YFT1/SlEIN2. This study elucidates the regulatory framework of fruit ripening in tomato, providing information that may be used to breed tomato hybrid cultivars with an optimal balance of shelf-life, durability, and high quality.
Detection and modelling of CH3NC in TMC-1
Authors: Tennis Jessica D , Xue Ci , Talbi Dahbia , Changala P Bryan , Sita Madelyn L , McGuire Brett , Herbst Eric 
Published: August 2023

ABSTRACT
Two closely related isomeric pairs of cyanides, CH3[CN/NC] and H2C[CN/NC], are studied in cold, dark interstellar cloud conditions. In contrast to the diverse detections of methyl cyanide (CH3CN) in space, methyl isocyanide (CH3NC) has previously only been observed in warm and hot star-forming regions. We report the detection of CH3NC in the cold pre-stellar core Taurus Molecular Cloud (TMC-1) using the Green Bank Telescope with a detection significance of 13.4σ. Hyperfine transitions in H2CCN and quadrupole interactions in CH3CN and CH3NC were matched to a spectral line survey from the Green Bank Telescope Observations of TMC-1: Hunting for Aromatic Molecules large project on the Green Bank Telescope, resulting in abundances with respect to hydrogen of $1.92^{+0.13}_{-0.07} \times 10^{-9}$ for the cyanomethyl radical (H2CCN), $5.02^{+3.08}_{-2.06} \times 10^{-10}$ for CH3CN, and $2.97^{+2.10}_{-1.37} \times 10^{-11}$ for CH3NC. Efforts to model these molecules with the three-phase gas-grain code nautilus in TMC-1 conditions overproduce both CH3CN and CH3NC, though the ratio of ∼5.9 per cent is consistent across observations and models of these species. This may point to missing destruction routes in the model. The models capture the larger abundance of H2CCN well. Dissociative recombination is found to be the primary production route for these molecules, and reactions with abundant ions are found to be the primary destruction routes. H + CH3NC is investigated with transition state theory as a potential destruction route, but found to be too slow in cold cloud conditions to account for the discrepancy in modelled and observed abundances of CH3NC.
Developmental Selection and the Perception of Mutation Bias
Authors: Majic Paco , Payne Joshua L 
Published: August 2023

Abstract
The notion that mutations are random relative to their fitness effects is central to the Neo-Darwinian view of evolution. However, a recent interpretation of the patterns of mutation accumulation in the genome of Arabidopsis thaliana has challenged this notion, arguing for the presence of a targeted DNA repair mechanism that causes a nonrandom association of mutation rates and fitness effects. Specifically, this mechanism was suggested to cause a reduction in the rates of mutations on essential genes, thus lowering the rates of deleterious mutations. Central to this argument were attempts to rule out selection at the population level. Here, we offer an alternative and parsimonious interpretation of the patterns of mutation accumulation previously attributed to mutation bias, showing how they can instead or additionally be caused by developmental selection, that is selection occurring at the cellular level during the development of a multicellular organism. Thus, the depletion of deleterious mutations in A. thaliana may indeed be the result of a selective process, rather than a bias in mutation. More broadly, our work highlights the importance of considering development in the interpretation of population-genetic analyses of multicellular organisms, and it emphasizes that efforts to identify mechanisms involved in mutational biases should explicitly account for developmental selection.
Interdisciplinary Analyses of Bronze Age Communities from Western Hungary Reveal Complex Population Histories
Authors: Gerber Dániel , Szeifert Bea , Székely Orsolya , Egyed Balázs , Gyuris Balázs , Giblin Julia I , Horváth Anikó , Köhler Kitti , Kulcsár Gabriella , Kustár Ágnes , Major István , Molnár Mihály , Palcsu László , Szeverényi Vajk , Fábián Szilvia , Mende Balázs Gusztáv , Bondár Mária , Ari Eszter , Kiss Viktória , Szécsényi-Nagy Anna 
Published: August 2023

Abstract
In this study, we report 21 ancient shotgun genomes from present-day Western Hungary, from previously understudied Late Copper Age Baden, and Bronze Age Somogyvár–Vinkovci, Kisapostag, and Encrusted Pottery archeological cultures (3,530–1,620 cal Bce). Our results indicate the presence of high steppe ancestry in the Somogyvár–Vinkovci culture. They were then replaced by the Kisapostag group, who exhibit an outstandingly high (up to ∼47%) Mesolithic hunter–gatherer ancestry, despite this component being thought to be highly diluted by the time of the Early Bronze Age. The Kisapostag population contributed the genetic basis for the succeeding community of the Encrusted Pottery culture. We also found an elevated hunter–gatherer component in a local Baden culture–associated individual, but no connections were proven to the Bronze Age individuals. The hunter–gatherer ancestry in Kisapostag is likely derived from two main sources, one from a Funnelbeaker or Globular Amphora culture–related population and one from a previously unrecognized source in Eastern Europe. We show that this ancestry not only appeared in various groups in Bronze Age Central Europe but also made contributions to Baltic populations. The social structure of Kisapostag and Encrusted Pottery cultures is patrilocal, similarly to most contemporaneous groups. Furthermore, we developed new methods and method standards for computational analyses of ancient DNA, implemented to our newly developed and freely available bioinformatic package. By analyzing clinical traits, we found carriers of aneuploidy and inheritable genetic diseases. Finally, based on genetic and anthropological data, we present here the first female facial reconstruction from the Bronze Age Carpathian Basin.