bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical Activation of Laryngeal Somatosensory-Motor Cortex During Vocalization in People With Unexplained Chronic Cough
Authors: Misono Stephanie , Xu Jiapeng , Oh Jinseok , Sombrio Anna , Stockness Ali , Mahnan Arash , Konczak Jürgen 
Published: July 2023

ImportanceUnexplained chronic cough is common and has substantial negative quality-of-life implications, yet its causes are not well understood. A better understanding of how peripheral and central neural processes contribute to chronic cough is essential for treatment design.ObjectiveTo determine if people with chronic cough exhibit signs of abnormal neural processing over laryngeal sensorimotor cortex during voluntary laryngeal motor activity such as vocalization.Design, Setting, and ParticipantsThis was a cross-sectional study of a convenience sample of participants with chronic cough and healthy participants. Testing was performed in an acoustically and electromagnetically shielded chamber. In a single visit, electroencephalographic (EEG) signals were recorded from participants with chronic cough and healthy participants during voice production. The chronic cough group participants presented with unexplained cough of 8 weeks or longer duration with prior medical evaluation including negative results of chest imaging. None of the participants had a history of any neurologic disease known to impair vocalization or swallowing. Data collection for the healthy control group occurred from February 2 to June 28, 2018, and for the chronic cough group, from November 22, 2021, to June 21, 2022. Data analysis was performed from May 1 to October 30, 2022.ExposureParticipants with or without chronic cough.Main Outcome MeasuresEvent-related spectral perturbation over the laryngeal area of somatosensory-motor cortex from 0 to 30 Hz (ie, θ, α, and β bands) and event-related coherence as a measure of synchronous activity between somatosensory and motor cortical regions.ResultsThe chronic cough group comprised 13 participants with chronic cough (mean [SD] age, 63.5 [7.8] years; 9 women and 4 men) and the control group, 10 healthy age-matched individuals (mean [SD] age, 60.3 [13.9] years; 6 women and 4 men). In the chronic cough group, the typical movement-related desynchronization over somatosensory-motor cortex during vocalization was significantly reduced across θ, α, and β frequency bands when compared with the control group.Conclusions and RelevanceThis cross-sectional study found that the typical movement-related suppression of brain oscillatory activity during vocalization is weak or absent in people with chronic cough. Thus, chronic cough affects sensorimotor cortical activity during the asymptomatic voluntary activation of laryngeal muscles.
Overcoming power efficiency limitation of white fluorescence light‐emitting diodes via multilevel‐hydrogen‐bond matrix
Authors: Du Ruiming , Ma Peng , Man Yi , Pang Yudong , Duan Chunbo , Han Chunmiao , Zhang Jing , Cao Chenhui , Wei Ying , Shui Xinfeng , Xu Hui 
Published: July 2023

AbstractHigh power efficiency and low efficiency roll‐off at practical luminance are two requirements for new‐generation energy‐saving lighting technologies, which are still bottlenecks of thermally activated delayed fluorescence (TADF) white organic light‐emitting diodes (WOLED), despite the advantages of TADF materials and devices in low cost and high sustainability. Herein, we developed a spiro phosphine oxide host named SSOXSPO, which can form multiple and multidirectional intermolecular hydrogen bonds (IHB). The resulted multilevel IHB network integrates long‐range ordered and short‐range disordered alignments for suppressing triplet‐polaron quenching (TPQ) and triplet‐triplet annihilation (TTA). Electronic characteristics of SSOXSPO matrix are further regulated, leading to the optimal exciton allocation through balancing energy and charge transfer. As consequence, using SSOXSPO as host, the single‐emissive‐layer TADF WOLEDs realized the record performance, including ultralow operation voltage as ∼4.0 V, power efficiency beyond fluorescent tube (70.1 lm W−1) and negligible external quantum efficiency roll‐off (3%) at 1000 nits for indoor lighting. This work demonstrates that multiple interplays supported by host matrixes in TADF WOLEDs can facilitate the synergistic effects of TADF emitters on 100% exciton utilization.
Oxygen‐Mediated Surface Photoreactions: Exploring New Pathways for Sustainable Chemistry
Authors: Alessandri Ivano , Vassalini Irene 
Published: July 2023

AbstractThis Concept analyses and reviews recent works that take advantage of oxygen‐mediated surface photoreactions for addressing key issues in the fields of sustainable chemistry, circular production of feedstocks and environmental remediation. Examples of metal and polymer recovery and recycling from waste, metal‐free oxidation of organic molecules and exploitation of persistent radicals for destroying pollutants and disinfection are discussed, highlighting common aspects, peculiarities, potential and limitations.
A comprehensive review of the influence of particle size and pore distribution on the kinetics of CO2 hydrate formation in porous media
Authors: Zhang Xuemin , Li Pengyu , Yuan Qing , Li Jinping , Shan Tao , Wu Qingbai , Wang Yingmei 
Published: July 2023

AbstractAs an essential greenhouse gas, CO2 is the leading cause of global warming and environmental problems. An efficient strategy to lower CO2 emissions is the hydrate‐based method of CO2 geological storage. The stability and formation process of hydrate is the premise and foundation of the hydrate method of CO2 geological storage. However, the formation rule of CO2 hydrate has a significant impact on the formation characteristics of CO2 hydrate. This paper thoroughly examines the formation properties of CO2 hydrate in porous media systems. The quantitative impacts and laws of many parameters on the CO2 hydrate production process are thoroughly examined. On this basis, the internal mechanism of particle size, pore distribution, and critical size of particles in porous media systems on the kinetics of CO2 hydrate formation are detailed. Finally, the shortcomings of the studies on CO2 hydrate formation kinetics in porous media systems and the main directions in the future are pointed out. The influence of pore distribution in porous media on the CO2 hydrate formation process still needs further study. The relative results will be useful in the future for CO2 capture and sequestration in sediments. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Diels‐Alder Macromolecular Networks in Recyclable, Repairable and Reprocessable Polymer Composites for the Circular Economy – A Review
Authors: Griffini Gianmarco , Rigatelli Benedetta , Turri Stefano 
Published: July 2023

AbstractIn the expanding field of high‐performance materials, polymer‐based thermoset composites play an important role due to their favorably‐high strength/weight ratio and their mechanical performance, thermal stability, and chemical resistance. However, their chemically‐crosslinked nature hampers their re‐processability and efficient recyclability, thus making them not compliant with the principles of the circular economy and of end‐of‐life valorization. Dynamic covalent polymers able to modify their network topology upon thermal stimulus can be considered valid alternatives to commonly used thermosets as they offer advantages in terms of recyclability and reusability, normally not achievable with conventional cross‐linked systems. Within the broad field of dynamic polymers, thermally‐triggered Diels‐Alder based materials represent reliable platforms with enormous technological and industrial potential as repairable, reusable and recyclable matrices in composites given their chemical versatility, suitable mechanical performance and ease of production and processing. In this review, a comprehensive discussion of the most recent demonstrations of the reversibility, reprocessability and recyclablability of such systems is provided, in the context of their use as polymer matrices in composites. It is hoped that this work will stimulate further discussion and research in the area of reversible polymer composites with increased functionality and extended lifetime, in view of their application in future circular economy scenarios.
Registration of eight germplasm lines of upland cotton (Gossypium hirsutum L.) resistant to reniform nematodes (Rotylenchulus reniformis) with elite agronomic performance
Authors: Bell Alois A. , Robinson A. Forest , Quintana Jose , Hinze Lori L. , Harris Jared , Liu Jinggao , Wagner Tanya , Prom Sandria , Saladino Vince , Zheng Xiuting , Stelly David M. , Nichols Robert L. 
Published: July 2023

AbstractCotton (Gossypium hirsutum L.) germplasm lines BARBREN‐713‐8 (Reg. no. GP‐1138, PI 701080), BARBREN‐713‐11 (Reg. no. GP‐1131, PI 701073), BARBREN‐713‐13 (Reg. no. GP‐1132, PI 701074), BARBREN‐713‐25 (Reg. no. GP‐1133, PI 701075), BARBREN‐713‐32 (Reg. no. GP‐1134, PI 701076), BARBREN‐713‐33 (Reg. no. GP‐1135, PI 701077), BARBREN‐713‐41 (Reg. no. GP‐1136, PI 701078), and BARBREN‐713‐48 (Reg. no. GP‐1137, PI 701079) were developed and released by the USDA‐ARS, Texas A&M AgriLife Research, and Cotton Incorporated in 2014. The objective of the release was to provide breeders with agronomically elite germplasm that is resistant to reniform nematode (Rotylenchulus reniformis). Four lines (BARBREN‐713‐8, ‐32, ‐33, and ‐48) also have simple sequence repeat (SSR) DNA markers for the Mi‐1 or Mi‐2 gene for resistance to root‐knot nematode [Meloidogyne incognita (Kolfoid & White) Chitwood]. The lines have excellent seedling vigor in fields infested with both nematodes and fungal root‐rot pathogens. Resistance to reniform nematode was transferred from G. barbadense GB713 (PI 608139) and is associated primarily with the Ren2GB713 gene on chromosome 21. This gene could be detected with the codominant SSR marker BNL3279_105 or the single nucleotide polymorphism marker GI‐187401. In controlled environment assays, these lines reported here suppressed numbers of reniform nematode eggs by 74–92% compared with ‘FiberMax FM966’. The lines outyielded and had fiber quality equal to or greater than several commercial cultivars.
MiR133b‐mediated inhibition of EGFR‐PTK pathway promotes rAAV2 transduction by facilitating intracellular trafficking and augmenting second‐strand synthesis
Authors: Huang Xiaoping , Wang Xiao , Li Ling , Wang Qizhao , Xu Wentao , Wu Wenlin , Xie Xiaolan , Diao Yong 
Published: July 2023

AbstractRecombinant adeno‐associated virus (rAAV) is an extremely attractive vector in the in vivo delivery of gene therapy as it is safe and its genome is simple. However, challenges including low permissiveness to specific cells and restricted tissue specificity have hindered its clinical application. Based on the previous studies, epidermal growth factor receptor‐protein tyrosine kinase (EGFR‐PTK) negatively regulated rAAV transduction, and EGFR‐positive cells were hardly permissive to rAAV transduction. We constructed a novel rAAV‐miRNA133b vector, which co‐expressed miRNA133b and transgene, and investigated its in vivo and in vitro transduction efficiency. Confocal microscopy, live‐cell imaging, pharmacological reagents and labelled virion tracking were used to analyse the effect of miRNA133b on rAAV2 transduction and the underlying mechanisms. The results demonstrated that miRNA133b could promote rAAV2 transduction and the effects were limited to EGFR‐positive cells. The increased transduction was found to be a direct result of decreased rAAV particles degradation in the cytoplasm and enhanced second‐strand synthesis. ss‐rAAV2‐miRNA133b vector specifically increased rAAV2 transduction in EGFR‐positive cells or tissues, while ss‐rAAV2‐Fluc‐miRNA133b exerted an antitumor effect. rAAV‐miRNA133b vector might emerge as a promising platform for delivering various transgene to treat EGFR‐positive cell‐related diseases, such as non‐small‐cell lung cancer.
DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study
Authors: Luo Mannan , Walton Esther , Neumann Alexander , Thio Chris H. L. , Felix Janine F. , van IJzendoorn Marinus H. , Pappa Irene , Cecil Charlotte A. M. 
Published: July 2023

BackgroundLateral ventricular volume (LVV) enlargement has been repeatedly linked to schizophrenia; yet, what biological factors shape LVV during early development remain unclear. DNA methylation (DNAm), an essential process for neurodevelopment that is altered in schizophrenia, is a key molecular system of interest.MethodsIn this study, we conducted the first epigenome‐wide association study of neonatal DNAm in cord blood with LVV in childhood (measured using T1‐weighted brain scans at 10 years), based on data from a large population‐based birth cohort, the Generation R Study (N = 840). Employing both probe‐level and methylation profile score (MPS) approaches, we further examined whether epigenetic modifications identified at birth in cord blood are: (a) also observed cross‐sectionally in childhood using peripheral blood DNAm at age of 10 years (Generation R, N = 370) and (b) prospectively associated with LVV measured in young adulthood in an all‐male sample from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 114).ResultsAt birth, DNAm levels at four CpGs (annotated to potassium channel tetramerization domain containing 3, KCTD3; SHH signaling and ciliogenesis regulator, SDCCAG8; glutaredoxin, GLRX) prospectively associated with childhood LVV after genome‐wide correction; these genes have been implicated in brain development and psychiatric traits including schizophrenia. An MPS capturing a broader epigenetic profile of LVV – but not individual top hits – showed significant cross‐sectional associations with LVV in childhood in Generation R and prospectively associated with LVV in early adulthood within ALSPAC.ConclusionsThis study finds suggestive evidence that DNAm at birth prospectively associates with LVV at different life stages, albeit with small effect sizes. The prediction of MPS on LVV in a childhood sample and an independent male adult sample further underscores the stability and reproducibility of DNAm as a potential marker for LVV. Future studies with larger samples and comparable time points across development are needed to further elucidate how DNAm associates with this clinically relevant brain structure and risk for neuropsychiatric disorders, and what factors explain the identified DNAm profile of LVV at birth.
Analysis of implant‐supported cantilever fixed partial denture: An in vitro comparative study on vertical misfit, stress distribution, and cantilever fracture strength
Authors: Peixoto Raniel Fernandes , Tonin Bruna Santos Honório , Pinto‐Fiamengui Lívia Maria Sales , Freitas‐Pontes Karina Mattes , Regis Rômulo Rocha , Mattos Maria da Glória Chiarello de 
Published: July 2023

AbstractPurposeTo evaluate the vertical misfit, stress distribution around dental implants, and cantilever fracture strength of 3‐unit implant‐supported cantilever fixed partial dentures (FPDs) using frameworks made from different materials and manufacturing techniques.Materials and MethodsForty FPDs were fabricated and divided into 5 groups (n = 8) based on the framework material used: LAS Co‐Cr (Conventional casting—laser welding); TIG Co‐Cr (Conventional casting –TIG welding); OP Co‐Cr (Conventional casting—one‐piece); CAD Co‐Cr (CAD‐CAM); and CAD Zr (CAD‐CAM ZrO2). The vertical misfit was evaluated before porcelain application (T1) and before (T2), and after thermomechanical cycling (T3) by stereomicroscopy. Cantilever fracture strength was tested with a 50 kN (5000 kgf) load cell at a crosshead speed of 0.5 mm/min. Qualitative and quantitative photoelastic analysis was performed to evaluate stress distribution at seven specific points in five FPDs (n = 1/group) subjected to occlusal loading.ResultsOnly the molar showed interaction among the three factors (G × S × T; F(20.932) = 1.630; p = 0.044). Thermomechanical cycling (T2 vs. T3) had a significant effect on intra‐group vertical misfit in molar, especially in LAS Co‐Cr (Δ = 5.87; p = 0.018) and OP Co‐Cr (Δ = 5.39; p = 0.007), with no significant effect in premolar (p > 0.05). Ceramic application combined with thermomechanical cycling (T1 vs. T3) caused a significant intra‐group increase in vertical misfit in all groups, both in the molar and premolar (p < 0.05). OP Co‐Cr was associated with greater vertical misfit and stress concentration. Frameworks manufactured by the CAD‐CAM system exhibited lower vertical misfit and better stress distribution. FPDs with metal frameworks (>410.83 ± 72.26 N) showed significantly higher fracture strength (p < 0.05) than zirconia (277.47 ± 39.10 N), and the first signs of ceramic veneering fracture were observed around 900 N.ConclusionsFPDs with frameworks manufactured using a CAD‐CAM system appear to be associated with lower vertical misfit and better stress distribution, although the section of the frameworks followed by welding may be a viable alternative. In addition, metal frameworks exhibit high fracture strength.
Effects of Performance and Normalized Parameters on Various Materials Based Multistage Thermoelectric Generator
Authors: Srivastava Kartik , Sahoo Rashmi Rekha 
Published: July 2023

Abstract
Multi-staging and variable cross section greatly improve the performance of thermoelectric generators. Hence, the present theoretical study analyzes a multi-stage-variable-shaped thermoelectric generator (MVS-TEG) for a combination of dissimilar materials. Effects on voltage, power, conversion efficiency, normalized constraints (voltage, power, and conversion efficiency), and second law efficiency with a row number, exhaust inlet temperature, and the coolant flowrate have been investigated. Results reveal that the row number is the most critical input parameter followed by exhaust inlet temperature and coolant flowrate. Also, the work gives optimum values of rows for voltage and power as Nx = 19 for MVS TEG-1, MVS TEG-3, and MVS TEG-4 while Nx = 18 for MVS TEG-2. The exhaust inlet temperature variation increases the voltage and power output by 54–59% and by 53–58% respectively. The coolant flow variation has a greater impact on the conversion efficiency and the average improvement in the efficiency is about 9.23% in the present study. The second law efficiency decreases with the increase in all the input parameters.
Hypocrisy, Knowledge, and the Rule of Blaming
Authors: Eylon Yuval 
Published: July 2023

Abstract
It is commonly accepted that non-hypocrisy is a condition of blaming, and that it is a moral condition. This paper proposes an alternative, epistemic, view of blaming: knowledge is necessary for blaming, and with the added condition that knowledge provides a (motivating) reason for action – sufficient.
First it is argued that knowing that the action of a blamee is wrong is necessary for blaming. Second, it is shown that the phenomenon of hypocritical blaming extends to circumstances not involving moral judgment (such as sports). Third, it is claimed that expressions of intentions such as (1) “A is wrong and I intend to do it” are infelicitous as they stand. The similarities between such expressions and hypocritical blaming recommend a unified account of their infelicity. Finally, it is argued that only the epistemic view of blaming provides accounts for both moral and non-moral blaming, and for the related phenomena.
Construction of Non-invasive Pre-diagnostic Index System for Diabetes Based on CACP Multilayer Screening Framework
Authors: li haotian , chai runqi , zhao xin , li chunnan , chen kaiyuan , chai senchun 
Published: July 2023

Abstract
Diabetes is becoming more and more prevalent, and preventing its occurrence has become a major challenge for society. In response, this article has established a non-invasive pre-diagnostic indicator system for diabetes using the CACP multi-layer data processing framework. The system consists of four main layers: cleaning, analysis, cross-validation, and processing. In the cleaning layer, indicators and subject groups with a high missing rate undergo screening, and missing data is processed through interpolation. The analysis layer analyzes the correlations between indicators of different types and categories, verifies and eliminates highly correlated indicators, and obtains a preliminary screening indicator set. In the cross-validation layer, the primary screening indicator set undergoes further processing to obtain a secondary indicator set. In the processing layer, the normalized and processed data is input into the xgboost classifier to obtain the AUC value and accuracy as a reference. Each indicator in each secondary indicator set is then deleted and processed to select the group of indicators with better results than the control group. Finally, the selected indicators are validated through the processing layer to obtain the best classification performance in the final screening feature set. Using part of the features and classification data from the Nhanes data in 2017-2018, the non-invasive pre-diagnostic indicator system for diabetes can achieve a classification accuracy of 0.91. This system only requires routine physical examination data such as height, weight, blood pressure, and some personal information to achieve autonomous non-invasive pre-diagnosis, making it an effective tool to prevent and treat diabetes.
A study of person re-identification approach utilizing an enhanced ConvNeXt architecture
Authors: Sun Xiaoming , Duan duanyan , Chen Yan , Zhang Junkai , Wang Yongliang , SU Bochao 
Published: July 2023

Abstract
In this paper, we present a new person re-identification method based on an improved ConvNeXt network, called ConvNeXt-AP. This method effectively captures pedestrian features, reduces computing resources, and improves recognition accuracy. ConvNeXt is used as the main network to enhance the capture of local spatial features, with the final forward head module removed to retain more pedestrian features. Moreover, the segmentation strategy from the PCB_RPP network is incorporated at the end of the model to extract fine-grained information from the pedestrian image. To improve the effectiveness of feed-forward convolutional neural networks, the ConvNeXt model Block implements the non-parametric attention mechanism SimAM. This mechanism infers the three-dimensional attention weight of the feature map without adding parameters to the original network, resulting in significant performance improvement with minimal maintenance overhead. To achieve stability and faster convergence, the model achieves stability over time by using a warm-up strategy, and during training, a random erasing strategy is used to reduce the risk of overfitting and improve robustness to occluded pedestrians. Our method has been rigorously tested on multiple public datasets of person re-identification, and the results demonstrate superior performance compared to many state-of-the-art methods.