bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic versus open pancreaticoduodenectomy for pancreatic and periampullary tumor: A meta-analysis of randomized controlled trials and non-randomized comparative studies
Authors: Yan Yong , Hua Yinggang , Chang Cheng , Zhu Xuanjin , Sha Yanhua , Wang Bailin 
Published: January 2023

ObjectiveThis meta-analysis compares the perioperative outcomes of laparoscopic pancreaticoduodenectomy (LPD) to those of open pancreaticoduodenectomy (OPD) for pancreatic and periampullary tumors.BackgroundLPD has been increasingly applied in the treatment of pancreatic and periampullary tumors. However, the perioperative outcomes of LPD versus OPD are still controversial.MethodsPubMed, Web of Science, EMBASE, and the Cochrane Library were searched to identify randomized controlled trials (RCTs) and non-randomized comparative trials (NRCTs) comparing LPD versus OPD for pancreatic and periampullary tumors. The main outcomes were mortality, morbidity, serious complications, and hospital stay. The secondary outcomes were operative time, blood loss, transfusion, postoperative pancreatic fistula (POPF), postpancreatectomy hemorrhage (PPH), bile leak (BL), delayed gastric emptying (DGE), lymph nodes harvested, R0 resection, reoperation, and readmission. RCTs were evaluated by the Cochrane risk-of-bias tool. NRCTs were assessed using a modified tool from the Methodological Index for Non-randomized Studies. Data were pooled as odds ratio (OR) or mean difference (MD). This study was registered at PROSPERO (CRD42022338832).ResultsFour RCTs and 35 NRCTs concerning a total of 40,230 patients (4,262 LPD and 35,968 OPD) were included. Meta-analyses showed no significant differences in mortality (OR 0.91, p = 0.35), serious complications (OR 0.97, p = 0.74), POPF (OR 0.93, p = 0.29), PPH (OR 1.10, p = 0.42), BL (OR 1.28, p = 0.22), harvested lymph nodes (MD 0.66, p = 0.09), reoperation (OR 1.10, p = 0.41), and readmission (OR 0.95, p = 0.46) between LPD and OPD. Operative time was significantly longer for LPD (MD 85.59 min, p &lt; 0.00001), whereas overall morbidity (OR 0.80, p &lt; 0.00001), hospital stay (MD −2.32 days, p &lt; 0.00001), blood loss (MD −173.84 ml, p &lt; 0.00001), transfusion (OR 0.62, p = 0.0002), and DGE (OR 0.78, p = 0.002) were reduced for LPD. The R0 rate was higher for LPD (OR 1.25, p = 0.001).ConclusionsLPD is associated with non-inferior short-term surgical outcomes and oncologic adequacy compared to OPD when performed by experienced surgeons at large centers. LPD may result in reduced overall morbidity, blood loss, transfusion, and DGE, but longer operative time. Further RCTs should address the potential advantages of LPD over OPD.Systematic review registrationPROSPERO, identifier CRD42022338832.
Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy
Authors: He Kangwen , Zhang Yucong , Li Shichao , Yuan Guanjie , Liang Ping , Zhang Qingpeng , Xie Qingguo , Xiao Peng , Li Heng , Meng Xiaoyan , Li Zhen 
Published: January 2023

PurposeTo investigate the incremental prognostic value of preoperative apparent diffusion coefficient (ADC) histogram analysis in patients with high-risk prostate cancer (PCa) who received adjuvant hormonal therapy (AHT) after radical prostatectomy (RP).MethodsSixty-two PCa patients in line with the criteria were enrolled in this study. The 10th, 50th, and 90th percentiles of ADC (ADC10, ADC50, ADC90), the mean value of ADC (ADCmean), kurtosis, and skewness were obtained from the whole-lesion ADC histogram. The Kaplan–Meier method and Cox regression analysis were used to analyze the relationship between biochemical recurrence-free survival (BCR-fs) and ADC parameters and other clinicopathological factors. Prognostic models were constructed with and without ADC parameters.ResultsThe median follow-up time was 53.4 months (range, 41.1-79.3 months). BCR was found in 19 (30.6%) patients. Kaplan−Meier curves showed that lower ADCmean, ADC10, ADC50, and ADC90 and higher kurtosis could predict poorer BCR-fs (all p&lt;0.05). After adjusting for clinical parameters, ADC50 and kurtosis remained independent prognostic factors for BCR-fs (HR: 0.172, 95% CI: 0.055-0.541, p=0.003; HR: 7.058, 95% CI: 2.288-21.773, p=0.001, respectively). By adding ADC parameters to the clinical model, the C index and diagnostic accuracy for the 24- and 36-month BCR-fs were improved.ConclusionADC histogram analysis has incremental prognostic value in patients with high-risk PCa who received AHT after RP. Combining ADC50, kurtosis and clinical parameters can improve the accuracy of BCR-fs prediction.
APTw combined with mDixon−Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma
Authors: Meng Xing , Tian Shifeng , Ma Changjun , Lin Liangjie , Zhang Xiaoxiao , Wang Jiazheng , Song Qingwei , Liu Ai Lian 
Published: January 2023

BackgroundTo investigate the value of amide proton transfer weighted (APTw) imaging combined with modified Dixon fat quantification (mDixon-Quant) imaging in determining the degree of differentiation of cervical squamous carcinoma (CSC) against histopathologic.MethodsMagnetic resonance imaging (MRI) data were collected from 52 CSC patients. According to histopathologic results, patients were divided into the poorly differentiated group (37 cases) and the well/moderately differentiated group (15 cases). The APTw value by APTw imaging and the fat fraction (FF) and transverse relaxation rate R2* values by mDixon-Quant were independently measured by two radiologists. Intra-class correlation coefficients (ICCs) were used to test the consistency of APTw, FF, and R2* values measured by the two observers. The Mann-Whitney U test was used to analyze the difference in each parameter between the two groups. Logistic regression analysis was used to assess the association between the degree of differentiation on histopathology and imaging parameters by APTw and mDixon Quant. The ROC curve was used to evaluate the diagnostic efficacy of various parameters and their combination in distinguishing the degree of CSC differentiation on histopathology. The DeLong test was used to access the differences among the area under the ROC curves (AUCs). The Pearson correlation coefficient was used to evaluate the correlation between APTw and mDixon-Quant imaging parameters.ResultsThe APTw means were 2.95 ± 0.78% and 2.05 (1.85, 2.65)% in the poorly and well/moderately differentiated groups, respectively. The R2* values were 26.62 (21.99, 33.31)/s and 22.93 ± 6.09/s in the poorly and well/moderately differentiated groups, respectively (P &lt; 0.05). The AUCs of APTw, R2*, and their combination were 0.762, 0.686, and 0.843, respectively. The Delong test suggested statistical significance between R2* and the combination of APTw and R2*. R2* values showed a significant correlation with APTw values in the poorly differentiated group.ConclusionsAPTw combined with mDixon-Quant can be used to efficiently distinguish the differention degrees of CSC diagnosed on histopathology.
Why age categories in youth sport should be eliminated: Insights from performance development of youth female long jumpers
Authors: Rüeger Eva , Javet Marie , Born Dennis-Peter , Heyer Louis , Romann Michael 
Published: January 2023

Long-term sports participation and performance development are major issues in popular sports and talent development programs. This study aimed to provide longitudinal trends in youth female long jump performance development, participation, and relative age effects (RAEs), as longitudinal data for female athletes are missing. 51′894 season’s best results of female long jump athletes (n = 16′189) were acquired from the Swiss Athletics online database and analyzed within a range of 6–22 years of age. To examine longitudinal performance development and RAEs, data from athletes who participated in at least three seasons were selected (n = 41′253) and analyzed. Performance development was analyzed using age groups (AGs) and exact chronological age (CA) at competition. Differences between performances of birth quarters were analyzed using 83% confidence intervals (CIs) and smallest worthwhile change. Odds ratios (ORs) with 95% CI were used to quantify RAEs. With the traditional classification into age groups (AG), performances of athletes born between January and March (Q1) were significantly better than those born between October and December (Q4) from U8 to U17. Using exact CA resulted in similar performances in Q1 and Q4 until the U20 age category. The peak of participation was reached in the U12 category, and then decreased until the U23 category with a substantial drop at U17. Significant RAEs were observed from U8 to U19 and at U22. RAEs continuously decreased from U8 (large effect) to U14 (small effect). The present results show that differences in performance arise from the comparison of athletes in AGs. Thus, going beyond AGs and using exact CA, Q4 athletes could benefit from a realistic performance comparison, which promotes fair performance evaluation, un-biased talent development, realistic feedback, and long-term participation.
The persistent impact of drought stress on the resilience of summer maize
Authors: Jing Lanshu , Weng Baisha , Yan Denghua , Zhang Shanjun , Bi Wuxia , Yan Siying 
Published: January 2023

Crop resilience refers to the adaptive ability of crops to resist drought at a certain level. Currently, most of the research focuses on the changes in root or photosynthesis traits of crops after drought and rehydration. Still, the persistence effect (drought period (T2) - rehydration period (T3) - harvest period (T4)) of drought stress on crops and quantitative estimation of resilience is still unclear. Field experiments were conducted in this study to determine the persistence effects on above-ground and below-ground growth indicators of summer maize at different levels and durations of drought. Next, an evaluation method for integrated resilience of summer maize was proposed, and a quantitative assessment of integrated resilience was made by Principal Component Analysis (PCA) and resilience index calculation. The results showed that the resilience of summer maize decreased with increasing drought levels, which persisted until harvest. Although summer maize resilience was strong after rewatering under light drought (DR1), declined after sustained rewatering. At the same time, production had decreased. However, a specific drought duration could improve the resilience of summer maize under light drought conditions. In particular, leaf biomass and root growth in the 30-50 cm layer could be enhanced under long duration light drought (LDR1), thus improving summer maize resilience and yield. Thus, under water shortage conditions, a certain level and duration drought could improve the resilience and yield of summer maize, which would persist until harvest. Clarifying the persistent effects on the growth indicators of summer maize and quantitatively evaluating the resilience of summer maize could improve agricultural food production and water use efficiency.
Comparative efficacy of various art therapies for patients with dementia: A network meta-analysis of randomized controlled trials
Authors: Liu Qian , Wang Fang , Tan Lixia , Liu Li , Cheng Hong , Hu Xiuying 
Published: January 2023

BackgroundDementia have brought great challenges to patients, families and society. Numerous art therapies for patients with dementia have been developed in recent years. However, it is still unclear which art therapy represents the optimal strategy for promoting physical and mental health.ObjectivesTo compare the efficacy of various art therapies in improving cognitive function, activity of daily living, depression, anxiety, agitation behavior and quality of life, and rank the art therapies for practice consideration.MethodsA comprehensive literature search was performed in eight electronic databases from their inception to April 2022. Two authors independently completed study selection, data extraction, and assessed methodological quality according to the revised version of the Cochrane tool (RoB 2). Comparative evaluation of different art therapies’ effect was performed by conducting network meta-analysis. The study protocol was registered at PROSPERO.ResultsA total of 39 randomized controlled trials involving 2801 participants were included. Calligraphy therapy (MD = 4.39) and reminiscence therapy (MD = 2.53) significantly improved cognitive function compared with the usual care, and reminiscence therapy (MD = 1.75) significantly enhanced cognitive function compared with music therapy. Horticultural therapy significantly decreased agitation behavior compared with the usual care (MD = −31.34), music therapy (MD = −26.66), reading therapy (MD = −28.44) and reminiscence therapy (MD = −27.32). In addition, calligraphy therapy (MD = 9.00) improved quality of life compared with the usual care.ConclusionCalligraphy therapy might be the most effective art therapy for improving cognitive function and quality of life. Horticultural therapy might be the best art therapy for decreasing agitation behavior. Health-care professionals could consider applying these art therapies to improve cognitive function, agitation behavior and quality of life in patients with dementia.
The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial
Authors: Amano Mizuki , Katayama Nariko , Umeda Satoshi , Terasawa Yuri , Tabuchi Hajime , Kikuchi Toshiaki , Abe Takayuki , Mimura Masaru , Nakagawa Atsuo 
Published: January 2023

BackgroundPessimistic thinking about the future is one of the cardinal symptoms of major depression. Few studies have assessed changes in pessimistic thinking after undergoing cognitive behavioral therapy (CBT). A randomized clinical trial (RCT) was conducted with patients diagnosed with major depressive disorder (MDD) to determine whether receiving a course of CBT affects pessimistic future thinking using a future thinking task.MethodsThirty-one patients with MDD were randomly assigned to either CBT (n = 16) or a talking control (TC) (n = 15) for a 16-week intervention. The main outcomes were the change in response time (RT) and the ratio of the responses for positive valence, measured by the future thinking task. Secondary outcomes included the GRID-Hamilton Depression Rating Scale, the Beck Depression Inventory-Second Edition (BDI-II), the Dysfunctional Attitude Scale (DAS), and the word fluency test (WFT).ResultsRegarding the main outcomes, the CBT group showed reduced RT for the positive valence (within-group Cohen’s d = 0.7, p = 0.012) and negative valence (within-group Cohen’s d = 0.6, p = 0.03) in the distant future condition. The ratio of positive valence responses in both groups for all temporal conditions except for the distant past condition increased within group (distant future: CBT: Cohen’s d = 0.5, p = 0.04; TC: Cohen’s d = 0.8, p = 0.008; near future: CBT: Cohen’s d = 1.0, p &lt; 0.001; TC: Cohen’s d = 1.1, p = 0.001; near past: CBT: Cohen’s d = 0.8, p = 0.005; TC: Cohen’s d = 1.0, p = 0.002). As for secondary outcomes, the CBT group showed greater improvement than the TC group regarding the need for social approval as measured by the DAS (p = 0.012).ConclusionPatients with MDD who received CBT showed a reduced RT for the positive and negative valence in the distant future condition. RT in the future thinking task for depressed patients may be a potential objective measure for the CBT treatment process. Because the present RCT is positioned as a pilot RCT, a confirmatory trial with a larger number of patients is warranted to elucidate the CBT treatment process that influences future thinking.Clinical trial registrationhttps://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000021028, identifier UMIN000018155.
Ten-year hospitalization trends in Mexico: Examining the profile of national and transient and migrants
Authors: Leyva-Flores René , Aracena-Genao Belkis , Bustamante Nirma D. , Bojorquez Ietza , Cortés-Alcalá Ricardo , Gómez-López Diana , Pérez-Sastré Miguel Adonai 
Published: January 2023

AimIn Mexico, as in other societies, migrants are seen as over-users of health services. However, the extent, distribution, and trends of use over time are unknown. Evidence is needed to inform health policies and improve health services for foreign patients. The objective of this study was to examine factors associated with the distribution and trends of Mexican and foreign resident hospitalizations in Mexican public hospitals from 2010 to 2020.MethodsA graphical and statistical analysis (descriptive and correlational) of discharge trends in public hospitals was carried out. Hospitalization trends were analyzed by country of habitual residence (Mexico, US, Central and South America, and Other Continents), age, sex, primary discharge category, and region of service delivery. Adjusted Poisson modeling was used to examine the factors associated with annual hospitalizations of Mexican and foreign residents.ResultsBetween 2010 and 2020, there were 26,780,808 hospitalizations in Mexican public hospitals. Of these, 0.05% were of foreign residents. Hospitalizations for Mexican residents remained stable from 2010 to 2019, while those for foreign residents trended upward over the same period. In 2020, hospitalizations of Mexican residents fell by 36.6%, while foreign resident hospitalizations fell by 348.8%. The distribution of hospitalizations by sex was higher among females for all categories of habitual residence, except among US residents. Obstetric discharges were the most common reason for hospitalization among Mexican residents (42.45%), Central and South American residents (42.24%), and residents from Other Continents (13.73%). The average hospital stay was 2 days. Poisson regression confirmed these results, showing that hospitalizations was higher among women (except among foreign residents) and in the ≤ 17 age group. Poisson modeling also showed that trauma injury was the leading cause of discharge for foreign residents after obstetric causes.DiscussionIt is unlikely the upward trend in hospitalizations among foreign residents in Mexico from 2010 to 2019 affected the Mexican public health system, given the small proportion (0.05%) of hospitalizations and the brief length of hospital stay. The increased number of hospitalizations during the study period may be explained by local and national measures to facilitate foreign residents' access to hospital services, while the decrease in hospital utilization in 2020 is likely associated with COVID-19. Geographic location and the most frequent primary discharge categories of hospitalizations within each population could provide evidence for modifications to public health policy in Mexico.
The pharmacokinetic and residue depletion study of eugenol in carp (Cyprinus carpio)
Authors: Xu Yidan , Jiao Yaqin , Yang Jian , Tan Aijuan , Ou Deyuan , Song Xuqin , Lv Shiming 
Published: January 2023

IntroductionThe pharmacokinetic profile and residue depletion of eugenol in carp (Cyprinus carpio) tissues and plasma were performed by a convenient and reliable high-performance liquid chromatography (HPLC) method.MethodsThe eugenol in carp tissues and plasma was extracted with a mixed solution of acetonitrile and methanol. N-hexane was used to remove lipid impurities. The method was successfully applied to the pharmacokinetic and residue elimination of eugenol in carp after the carp was administered a medicated bath.ResultsThe average recoveries of eugenol in tissues and plasma fortified with four concentration levels were 69.0–106.6% and 80.0–86.7%, respectively. The relative standard deviations were &lt; 8.9%. The limit of detection (LOD) was 0.01 μg/g in tissue and 0.008 μg/ml in plasma, respectively. The pharmacokinetic parameter of Cmax for eugenol in plasma at the concentrations of 20, 35, and 75 mg/L were 10.86, 17.21, and 37.32 mg/L, respectively. The t1/2 values were 3.68, 4.22, and 9.31 h. After the investigation of the anesthetic effect, 35 mg/L of eugenol was the optimal concentration for anesthesia. The highest accumulation concentration of eugenol in carp is in the liver and the lowest is in the muscle. In addition, the eugenol in tissue was eliminated rapidly and at a lower level than the LOD at 48 h. According to the residue elimination, the withdrawal time of eugenol was suggested at 5.2 days.DiscussionThese results indicate that the developed method had good linearity and accuracy, and is sensitive enough for the monitoring of eugenol residue in carp. The half-life of eugenol decreased with the increase in drug concentration and the eugenol was eliminated rapidly in carp tissues. 35 mg/L eugenol was recommended as an anesthetic in carp due to its favorable anesthetic effect and no mortality. This study will contribute to the establishment of MRL regulation and setting a withdrawal period.
À propos des technologies domestiques : quand les mères parlent de liberté et les filles d'indépendance
Authors: Coutras Jacqueline , Lacascade Jean-louis 
Published: January 2023

Jeunes Parisiennes des années cinquante, jeunes Parisiennes des années quatre-vingts. Deux générations. Deux contextes socioculturels. Une même lignée. Beaucoup sépare les mères et les filles, et pourtant... La mère, comme la fille, cherchent à donner d’elles-mêmes une image de femme «indépendante» qui sait sortir de chez elle, dont l’univers dépasse le logement et les préoccupations familiales et domestiques. Dans cette ouverture sur l’extérieur, l’usage d’une voiture lui a été d’une grande aide, mais aussi celui d’un lave-linge et d’un réfrigérateur. Aujourd’hui, pour décharger sa fille, la grand-mère reçoit et garde ses petits enfants. Mais elle veut poser des bornes à l’aide qu’elle apporte à sa fille, car elle aussi entend s’assurer une vie «autonome» - autonome de celle du mari, de celle de ses enfants. Elle aussi cherche une socialisation extérieure.
Elle a autant d’équipements domestiques que sa fille - ou presque. Elle les a acquis pour réduire le nombre de tâches domestiques et surtout leur répétitivité. «Simplifier la vie quotidienne » : mère et fille ont la même attitude. Elles se présentent comme des femmes «indépendantes» ; cela ne signifie pas qu’elles estiment être «modernes».
Aktivitas positif bisnis, apakah sudah mencerminkan etika bisnis yang baik atau malah sebaliknya ?
Authors: Permadi Rafifah Adelia Putri , Acintya Sannidya Tara , Yulianti Yessica Silva 
Published: January 2023

Etika adalah suatu aspek penting dan sifatnya mendasari perilaku manusia. Dalam kaitannya dengan dunia bisnis, etika bisnis juga merupakan hal utama yang harus dijaga oleh semua pelaku bisnis sebagai bentuk tanggung jawabnya terhadap masyarakat dan lingkungan. Namun, di Indonesia sendiri masih terdapat banyak permasalahan terkait penyimpangan etika bisnis, misalnya korupsi, pemanfaatan kegiatan CSR yang hanya digunakan sebagai formalitas belaka, dan bentuk permasalahan moral lainnya. Lalu, apa yang seharusnya dilakukan oleh Indonesia untuk mengubah pandangan mereka dalam berbisnis, agar terbentuk etika yang sesuai dengan jati diri bangsa?. Dengan demikian, tidak ada lagi pihak-pihak yang dirugikan atas penyimpangan etika bisnis yang dilakukan.
Kata Kunci : CSR, Korupsi.