bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenic Nanoparticles: Synthesis, Characterization, and Biological Potential
of Gold Nanoparticles Synthesized using Lasiosiphon eriocephalus
Decne Plant Extract
Authors: Datkhile Kailas D. , Durgawale Pratik P. , Chakraborty Shuvronil , Jagdale Nilam J. , More Ashwini L. , Patil Satish R. 
Published: February 2023

Introduction:
Recent advancements in biomedicine have revolutionized nanomedicine
as a therapeutic moderator in the management of both infectious and noninfectious diseases.

Purpose:
In the current study we demonstrated biosynthesis of gold nanoparticles using aqueous
leaf extract of Lasiosiphon eriocephalus as a capping and reducing agent and evaluation of their
antioxidant, antibacterial, and anticancer properties.

Methods:
The biosynthesized LE-AuNPs were characterized by UV-Vis spectrophotometry,
SEM, TEM, XRD, FTIR, DLS, and Zeta potential analysis. The antibacterial activity was
checked by a minimum inhibitory concentration assay. The anticancer potential of biogenic
LE-AuNPs was checked by cytotoxicity and genotoxicity assay against HeLa and HCT-15 cells.

Results:
The characteristic surface plasmon resonance peak of the colloidal solution at 538 nm
by UV-Vis spectrum confirmed the formation of LE-AuNPs in the solution. The SEM, TEM, and
XRD revealed 20-60 sized hexagonal and crystalline LE-AuNPs. The LE-AuNPs displayed significant
inhibition potential against DPPH and ABTS radicals in vitro. The LE-AuNPs demonstrated
significant antibacterial potential. The results of cytotoxicity interpreted that biogenic
gold nanoparticles exhibited strong dose and time-dependent cytotoxicity effect against selected
cancer cell lines where IC50 of LE-AuNPs required to inhibit the growth of HeLa cells after 24 h
and 48 h exposure were 5.65± 0.69 μg/mL and 4.37±0.23 μg/mL respectively and that of HCT-
15 cells was 6.46 ± 0.69 μg/mL and 5.27 ± 0.34 μg/mL, 24h and 48h post-exposure respectively.

Conclusions:
Findings from this study revealed that gold nanoparticles synthesized using L. eriocephalus,
showed remarkable antioxidant, antimicrobial, and extensive cytotoxicity and genotoxicity
activities.
Improving Communication in Intensive Care Unit to Ward Transitions: Protocol for Multisite National Implementation of the ICU-PAUSE Handoff Tool
Authors: Fukui Elle Mizuki , Lyons Patrick G , Harris Emily , McCune Emma K , Rojas Juan C , Santhosh Lekshmi 
Published: February 2023

Background
The intensive care unit (ICU)–ward transfer poses a particularly high-risk period for patients. The period after transfer has been associated with adverse events and additional work for care teams related to miscommunication or omission of information. Standardized handoff processes have been found to reduce communication errors and adverse patient events in other clinical environments but are understudied at the ICU-ward interface. We previously developed an electronic ICU-ward transfer tool, ICU-PAUSE, which embeds the key elements and diagnostic reasoning to facilitate a safe transfer of care at ICU discharge.

Objective
The aim of this study is to evaluate the implementation process of the ICU-PAUSE handoff tool across 10 academic medical centers, including the rate of adoption and acceptability, as perceived by clinical care teams.

Methods
ICU-PAUSE will be implemented in the medical ICU across 10 academic hospitals, with each site customizing the tool to their institution’s needs. Our mixed methods study will include a combination of a chart review, quantitative surveys, and qualitative interviews. After a 90-day implementation period, we will conduct a retrospective chart review to evaluate the rate of uptake of ICU-PAUSE. We will also conduct postimplementation surveys of providers to assess perceptions of the tool and its impact on the frequency of communication errors and adverse events during ICU-ward transfers. Lastly, we will conduct semistructured interviews of faculty stakeholders with subsequent thematic analysis with the goal of identifying benefits and barriers in implementing and using ICU-PAUSE.

Results
ICU-PAUSE was piloted in the medical ICU at Barnes-Jewish Hospital, the teaching hospital of Washington University School of Medicine in St. Louis, in 2019. As of July 2022, implementation of ICU-PAUSE is ongoing at 6 of 10 participating sites. Our results will be published in 2023.

Conclusions
Our process of ICU-PAUSE implementation embeds each step of template design, uptake, and customization in the needs of users and key stakeholders. Here, we introduce our approach to evaluate its acceptability, usability, and impact on communication errors according to the tenets of sociotechnical theory. We anticipate that ICU-PAUSE will offer an effective handoff tool for the ICU-ward transition that can be generalized to other institutions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/40918
Tracking Population-Level Anxiety Using Search Engine Data: Ecological Study
Authors: Gilbert Barnabas James , Lu Chunling , Yom-Tov Elad 
Published: February 2023

Background
Anxiety disorders are the most prevalent mental disorders globally, with a substantial impact on quality of life. The prevalence of anxiety disorders has increased substantially following the COVID-19 pandemic, and it is likely to be further affected by a global economic recession. Understanding anxiety themes and how they change over time and across countries is crucial for preventive and treatment strategies.

Objective
The aim of this study was to track the trends in anxiety themes between 2004 and 2020 in the 50 most populous countries with high volumes of internet search data. This study extends previous research by using a novel search-based methodology and including a longer time span and more countries at different income levels.

Methods
We used a crowdsourced questionnaire, alongside Bing search query data and Google Trends search volume data, to identify themes associated with anxiety disorders across 50 countries from 2004 to 2020. We analyzed themes and their mutual interactions and investigated the associations between countries’ socioeconomic attributes and anxiety themes using time-series linear models. This study was approved by the Microsoft Research Institutional Review Board.

Results
Query volume for anxiety themes was highly stable in countries from 2004 to 2019 (Spearman r=0.89) and moderately correlated with geography (r=0.49 in 2019). Anxiety themes were predominantly long-term and personal, with “having kids,” “pregnancy,” and “job” the most voluminous themes in most countries and years. In 2020, “COVID-19” became a dominant theme in 27 countries. Countries with a constant volume of anxiety themes over time had lower fragile state indexes (P=.007) and higher individualism (P=.003). An increase in the volume of the most searched anxiety themes was associated with a reduction in the volume of the remaining themes in 13 countries and an increase in 17 countries, and these 30 countries had a lower prevalence of mental disorders (P<.001) than the countries where no correlations were found.

Conclusions
Internet search data could be a potential source for predicting the country-level prevalence of anxiety disorders, especially in understudied populations or when an in-person survey is not viable.
Muhammad Quraish Shihab’s Methodology in Interpretation of The Qur'an
Authors: Aiyub Aiyub , Mutia Isna 
Published: February 2023

One of Prof. Dr. Muhammad Quraish Shihab's books on archipelago interpretation is titled Tafsir al-Misbah and was authored in Indonesian. It took almost four years to complete, from 1999 to 2002. This interpretation book has added a treasure of interpretation in the Archipelago. It needs to be examined because its author is an expert on interpretation in Indonesia. Besides, he is one of the contemporary scholars. Therefore, this study examines the author’s personality of al-Misbah interpretation book and examines its methodology in interpreting Qur’an, whether he uses the methodology of al-Ma'thur, al-Ra'y or al-Isyari in terms of sources the reference, or he uses the tahlili, al-muqarrin, al-Ijmali and al-Maudhu'i methods in terms of delivery. This article also seeks to ascertain the author's preferred method of interpretation, such as al-Fiqhi, al-adab al-Lughawi, al-adab al-Ijtima'i, etc. This study, which employs library technique, discovers that the al-Ma'thur and al-ra'yi methods, which are excellent for referencing, are used in this commentary book, whereas the tahlili method is used for delivery. It leans toward the interpretation of al-Adab al-Ijtima'i. This interpretation excels in discussing both language and the munasabah (appropriateness of the arrangement) of verses and surahs in the Qur'an.
Pengaruh Media Pembalajaran Daring Terhadap Motivasi Belajar Siswa-Siswi SMA Cenderawasih 1 Jakarta
Authors: Trisnawan Irlan , Raymond Andree 
Published: February 2023

Pendidikan adalah suatu hal yang penting di masyarakat. Demi menjadi bangsa yang memiliki kecerdasan yang baik tentu harus mengikuti aturan kementrian pendidikan dan harus di dukung juga oleh aturan yang sistematis dari pemerintah itu sendiri.Pada saat sekarang, dunia sedang digemparkan dengan adanya Covid-19. Virus ini sendiri baru ditemukan pertama di Cina, menurut media South China Morning Post kasus awal Covid-19 tersebut terdeteksi pada 17 November 2019 dan setiap harinya mengalami peningkatan
STRATEGI PROMOSI DIGITAL DALAM MEMPERTAHANKAN EKUITAS MERK DI ERA NEW NORMAL (STUDI KASUS PADA PT. JAVA FESTIVAL PRODUCTION 2022)
Authors: Yatna Tsar Syahputra , Hereyah Yoyoh 
Published: February 2023

Abstrak. Tujuan penelitian ini untuk mengungkap bagaimana analisa SWOT strategi promosi digital PT. Java Festival Production, serta bagaimana strategi promosi digital PT. Java Festival Production dalam mempertahankan ekuitas merek. Akibat pandemi, kiblat komunikasi cukup berubah. Perkembangan strategi promosi digital menimbulkan persaingan agar merek dapat menempati posisi teratas. Analisis SWOT digunakan pada asumsi bahwa suatu strategi yang efektif akan meminimalkan kelemahan dan ancaman Kemudian teori strategi komunikasi digital untuk mengetahui fokus segmen yang paling bernilai bagi perusahaan pada saat merancang strategi pemasaran produk dan cara penyampaian pesan yang paling relevan. Penelitian ini menggunakan pendekatan kualitatif dibantu dengan metode studi kasus. PT. JFP menggunakan tiga tahapan utama dalam menjalankan strategi promosi digital yakni; Tahap strategy formulation, strategy implementation, strategy evaluation. Kata Kunci : SWOT, Strategi Promosi Digital, Ekuitas Merek, New Normal
A calculus for intuitionistic fuzzy values
Authors: Yavuz Enes 
Published: February 2023

We introduce calculus
and calculus for intuitionistic
fuzzy values and prove some basic theorems by using multiplicative
calculus which has useful tools to represent the concepts of introduced
calculi. Besides, we construct some isomorphic mappings to interpret the
relationships between calculus
and calculus. This paper reveals
also new calculi for fuzzy sets in particular.
Twenty-year follow-up of functional treatment with a bionator appliance (part 2): a retrospective cephalometric analysis of skeletal and dentoskeletal changes
Authors: Jungbauer Rebecca , Bock Niko C. , Schmid Alois , Proff Peter , Rudzki Ingrid 
Published: February 2023

ABSTRACTObjectivesTo investigate skeletal and dentoskeletal changes 20 years after bionator treatment.Materials and MethodsAnalog lateral cephalograms of 18 subjects treated with a bionator appliance during growth were digitized with a transmitted light scanner. Inclusion criteria were: increased overjet (≥4 mm), skeletal Class II, available lateral cephalograms before (T0), after (T1), and 20 years after (T2) treatment with only a Bionator. To assess standard cephalometric parameters, the software ivoris analyze was used. Data were analyzed using Friedman's two-way analysis of variance by ranks followed by Dunn's post hoc tests (P ≤ .05).ResultsDuring therapy (T0–T1), ANB decreased significantly by 1.9° and remained unchanged long term. SNA slightly decreased (−0.6°) during treatment, SNB and SNPg increased (+1.4°, +1.7°). All three parameters showed a significant increase at T2 (+1.2°, +1.6°, +1.6°). Vertical measurements (ML-NL, ML-NSL, NL-NSL) remained almost unchanged during therapy. NL-NSL also was unchanged during the long-term interval; ML-NSL and ML-NL decreased significantly (−3.4°, −4.9°). During treatment, the maxillary incisors retroclined (OK1-NL: −1.6°, OK1-NA: −0.6°), the mandibular incisors proclined (UK1-ML: +3.5°, UK1-NB: +4.9°), neither significantly. Long term, there was a nonsignificant tendency toward proclination of upper (OK1-NL: +0.1°, OK1-NA: +0.7°) and retroclination of lower incisors (UK1-ML: −1.5°, UK1-NB: −5°).ConclusionsChanges of ANB after bionator treatment without additional fixed appliances remained stable after 20 years. The observed long-term changes are probably consequences of well-known physiological and age-related processes.
Causes of the Evidence-practice Gap and Its Association with the Effects of Minimal Intervention Dentistry Education to Clinicians
Authors: Yokoyama Y , Kakudate N , Sumida F , Matsumoto Y , Gordan VV , Gilbert GH 
Published: February 2023

SUMMARY

Objectives
To identify causes of the evidence-practice gap (EPG) in dentistry in Japan and analyze whether these causes are associated with: (a) improvement of EPG in minimal intervention dentistry (MID) following an educational intervention and (b) specific dentist characteristics.

Methods
We conducted a mixed-methods questionnaire survey among 197 Japanese dentists that integrated both quantitative and qualitative data. Causative factors for the EPG identified in the quantitative survey were clarified by qualitative analysis. We measured the EPG in a baseline survey using an EPG measurement tool based on MID. To examine how feedback using the latest scientific evidence affected change in the EPG, we measured the EPG again immediately after feedback was provided to participating dentists.

Results
Qualitative analysis classified all dentists into one of four “EPG cause” groups, namely “evidence-”, “dentist-”, “patient-”, and “health insurance system-related” causes. Quantitative analysis confirmed that improvement in the EPG following the feedback intervention was indeed associated with group classification. The highest concordance was found for the “evidence-related” group while the lowest concordance was in the “dentist-related” group (p=0.004). Concordance improved after evidence feedback in all groups but was lowest in the “dentist-related” group. More dentists reported practice busyness in the “dentist-related” group.

Conclusions
In this study, we identified four groups of causes of EPG among Japanese dentists. The degree of concordance between evidence and clinical practice was the lowest in the “dentist-related” group, and the results of this study are expected to provide useful information for the development of intervention methods for closing the EPG in the future.
Effect of Multiple Firings on the Microshear Bond Strength Between a Translucent Zirconia and a Resin Cement
Authors: Grangeiro MTV , Demachkia AM , Rodrigues CS , Inagati CM , Gonçalves NMF , Tanaka IV , Rossi NR , Bottino MA 
Published: February 2023

SUMMARYPurposeThis study investigated the microshear bond strength between a resin cement and a translucent zirconia subjected to multiple characterization firings.Methods and Materials5Y-PSZ zirconia blocks (Katana UTML) were sliced, sintered (1550°C, 2 h), and randomly divided into six groups (n=10) according to the number of characterization firings (0, 1, 2, 3, 5, or 10) and aging (baseline or after thermocycling). Each characterization firing was performed at 750°C for 1 minute. The ceramic surfaces were all sandblasted with 50 μm Al2O3 and silanized. Then, cylinders of resin cement (0.96 mm diameter × 2 mm height) were bonded onto their surfaces. The baseline samples were immersed in distilled water for 24 hours before the microshear bond strength (μSBS) tests. The aged samples were tested after 5000 thermocycles in water (5°C–55°C). The failure modes were classified as adhesive, predominantly adhesive, or cohesive. Scanning electron microscope images of the failure modes and the ceramic surfaces after the firings were taken. The μSBS data were analyzed by two-way ANOVA and Tukey’s test.ResultsThe number of characterization firings and aging affected the bond strength. The highest bond strength values were observed from the 2-firing group at baseline. The μSBS results after 1, 2, or 3 characterization firings were similar at baseline and after aging. On the other hand, 0, 5, and 10 firings revealed the lowest bond strengths. The most frequent failures were adhesive and predominantly adhesive. Zirconia grains were not affected by the multiple firings.ConclusionOne to three characterization firings after sintering improve the bond strength of 5Y-PSZ to the resin cement when compared to none or several (five or ten) firing cycles.
The Role of Ultrasound in Diagnosing Community-Acquired Pneumonia
Authors: Starostin D. O. , Kuzovlev A. N. 
Published: February 2023

BACKGROUND The literature review is devoted to an urgent problem of the diagnosis of pneumonia in the practice of an anesthesiologist-resuscitator using ultrasound. The literature review describes the methodological foundations of this method, its advantages and disadvantages, sensitivity and specificity for the diagnosis of severe community-acquired pneumonia in the practice of an anesthesiologist-resuscitator.AIM OF STUDY The analysis of the most modern domestic and foreign evidence base based on the information content of lung ultrasound in CAP in the practice of an anesthesiologist-resuscitator.MATERIAL AND METHODS Russian publications were searched in the elibrary.ru database, foreign publications were searched in the PubMed database. Publications (literature reviews, observational studies, double-blind randomized trials) were searched for the period 2010–2020. A total of 1379 publications were initially selected, identified through database searches. After removing duplicates, the number of publications was reduced to 695. Of this number, 503 publications were excluded. The remaining 192 full-text articles were evaluated for text acceptability. Due to inconsistency with the main sections of the review, 77 articles were deleted from them. The remaining 115 ones were included in the qualitative synthesis and 67 ones were selected in the quantitative synthesis.RESULTS The ultrasound is a promising and worthy alternative to other imaging modalities. According to the results chest X-ray was inferior to lung ultrasound in diagnosing the presence of fluid in the pleural cavities. The sensitivity of ultrasound in assessing pleural effusion reaches 100%, the specificity is 99.7%. Pulmonary ultrasonography plays an important role in the diagnosis of pneumonia and is a promising alternative to chest X-ray and chest CT.DISCUSSION Since POCUS is performed at the patient’s bedside, the results are available to the doctor in real time, which helps in diagnosis and treatment. Sequential examinations can be performed to monitor disease progression and response to treatment. However, many facilities do not have the ability to store ultrasound images, so other healthcare professionals cannot see them.FINDINGS The ultrasound examination of the lungs is unlikely to replace computed tomography of the chest, as it does not have 100% specificity, however, it is indispensable in bedside examination and is the doctor’s sonographic “stethoscope”, which significantly expands diagnostic capabilities.
News as a Means of Popularization of First Aid Knowledge: Content Analysis of News Articles Related to Cases of Pediatric Cardiac Arrest in Schools and Kindergartens of Russia
Authors: Birkun A. A. , Samarin S. A. , Tupotilova A. A. 
Published: February 2023

RELEVANCE In Russia, insufficient motivation and low readiness of laypeople to provide first aid (FA) stipulate low rates of bystander cardiopulmonary resuscitation (CPR) and, as consequence, high mortality from cardiac arrest (CA). News reports on real cases of CA, in addition to describing circumstances of the event, may carry important information promoting FA provision among a wide audience. However, existing practice of presenting such content in Russian media sphere is unknown.AIM To investigate contemporary trends for presentation of information on the problem of CA and provision of help in CA in reports of online news media on the example of a news sample about cases of pediatric CA in kindergartens and schools of Russia.MATERIAL AND METHODS In August 2021, Google and Yandex were searched for Russian-language news reports describing cases of CA that happened in children in Russian schools and kindergartens in 2020, and structured content analysis of the news was carried out.RESULTS The study sample consisted of 207 news reports describing 21 unique case of CA. In 76.2% cases (n=16) CA occurred in children at school, in 23.8% cases (5) — at kindergarten. At least in 28.6% of cases (6) Emergency Medical Services providers did not attempt CPR at arrival on scene. FA provision by bystanders was described in two cases (9.5%), provision of help by medical employees of educational organizations — in six cases (28.6%). Only in one case (4.8%) the child was transferred to a hospital after successful resuscitation. In the rest of cases (n=20; 95.2%) biological death was verified on scene. Information on the value of FA for saving life in CA was present in one out of 207 news reports (0.5%); and there were no reports mentioning legal aspects of FA provision, describing procedure of FA in CA, or highlighting the importance of mass public resuscitation education.CONCLUSIONS News reports that describe cases of CA confirm high relevance of the problem, but do not carry important information related to popularization of FA knowledge. Inclusion of information on significance, principles and procedures of providing FA to CA victims into the content of the news reports is necessary for establishing positive public opinion and increasing motivation of the general population of Russia towards training in FA and FA provision. This in turn indicates the necessity for enhancing awareness of the professional journalistic community on the problem of FA provision in CA.