bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary testicular microcystic stromal tumor: two case reports with a broad morphological spectrum and frequency of predilection site
Authors: LIU HONG , Zheng Jiawen , Wang Xiaotong , Zhou Xiaodie , Wang Xuan , Ye Shengbing , Shi Qunli , Zhou Xiaojun , Shen Qin 
Published: June 2023

Abstract
Background
The microcystic stromal tumor (MCST) is a rare neoplasm included in the category of pure stromal tumors of the ovary. Only two cases were previously reported to occur in the testis. Here, two additional cases of testicular MCST presented with clinicopathological manifestation, immunohistochemical profile and genomic analysis.
Materials and methods
Retrospectively, detailed data on these cases were collected by morphological observation, immunohistochemistry staining (IHC) and next-generation sequencing (NGS) test.
Results
The two patients aged 31 and 34 years found accidentally a solid mass of 2.1 cm and 1.7 cm in diameter on radiological images. Microscopically, the tumors showed nodular or lobular growth arranged in a variety of structures, such as microcystic, solid, macrocystic or cords, mixed with hyalinization stroma in variable proportions. No atypical mitotic figure or necrosis was observed. Immunohistochemically, both were strongly positive for β-catenin (nuclear and cytoplasmic staining), CD10 and CD99, while negative for α-inhibin and calretinin. NGS analysis revealed missense mutation in exon 3 of CTNNB1. They were disease-free 30 to 45 months after initial diagnosis.
Conclusion
The MCST, particularly in testis, is extremely rare and characterized by classical morphology. Our findings indicate that the MCST would have broader morphological spectrum but relatively constant immunophenotypes and molecular events to those of ovarian tumors reported.
A nomogram was developed using clinicopathological features to predict postoperative liver metastasis in patients with colorectal cancer
Authors: Dou Xinyu , Xi Jiaona , Zheng Gaozan , Ren Guangming , Tian Ye , Dan Hanjun , Xie Zhenyu , Niu Liaoran , Duan Lili , Li Ruikai , Wu Hongze , Feng Fan , Zheng Jianyong 
Published: June 2023

Abstract
Purpose
The objective of this study is to examine the risk factors that contribute to the development of liver metastasis (LM) in patients who have suffered radical resection for colorectal cancer (CRC), and to establish a nomogram model that can be used to predict the occurrence of the LM.
Methods
The present study enrolled 1377 patients diagnosed with CRC between January 2010 and July 2021. The datasets were allocated to training (n = 965) and validation (n = 412) sets in a randomly stratified manner. The study utilized univariate and multivariate logistic regression analysis to establish a nomogram for predicting LM in patients with CRC.
Results
Multivariate analysis revealed that T stage, N stage, number of harvested lymph nodes (LNH), mismatch repair (MMR) status, neutrophil count, monocyte count, postoperative carcinoembryonic antigen (CEA) levels, postoperative cancer antigen 125 (CA125) levels, and postoperative carbohydrate antigen 19 − 9 (CA19-9) levels were independent predictive factors for LM after radical resection. These factors were then utilized to construct a comprehensive nomogram for predicting LM. The nomogram demonstrated great discrimination, with an area under the curve (AUC) of 0.782 for the training set and 0.768 for the validation set. Additionally, the nomogram exhibited excellent calibration and significant clinical benefit as confirmed by the calibration curves and the decision curve analysis, respectively.
Conclusion
This nomogram has the potential to support clinicians in identifying high-risk patients who may develop LM post-surgery. Clinicians can devise personalized treatment and follow-up plans, ultimately leading to an improved prognosis for patients.
Short-term feed supplementation with alcoholic extract of Artemisia annua improves health conditions and productive performance of juvenile Nile tilapia (Oreochromis niloticus)
Authors: Soares Michelly Pereira , Angelis Carolina Fernandes , Silva Ludmila Mendes , Montanari Beatriz Helena , Campos Cristiane Meldau , Queiroz Sonia Claudia Nascimento , Fernandes Marisa Narciso , Longhini Wolney , Peres Miguel , Leite Cléo Alcantara Costa , Rantin Francisco Tadeu , Sampaio Fernanda Garcia 
Published: June 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Assessing the Competence of ChatGPT-3.5 Artificial Intelligence System in Executing the ACLS Protocol of the AHA 2020
Authors: Altundağ İbrahim , Doğruyol Sinem , Yavuz Burcu Genç , Yusufoğlu Kaan , Afacan Mustafa Ahmet , Çolak Şahin 
Published: June 2023

Abstract
Objectives: Artificial intelligence (AI) has become the focus of current studies, particularly due to its contribution in preventing human labor and time loss. The most important contribution of AI applications in the medical field will be to provide opportunities for increasing clinicians' gains, reducing costs, and improving public health. This study aims to assess the proficiency of ChatGPT-3.5, one of the most advanced AI applications available today, in its knowledge of current information based on the American Heart Association (AHA) 2020 guidelines.
Methods: An 80-question quiz in a question-and-answer format, which includes the current AHA 2020 application steps, was prepared and applied to ChatGPT-3.5 in both English (ChatGPT-3.5 English) and native language (ChatGPT-3.5 Turkish) versions in March 2023. The questions were prepared only in the native language for emergency medicine specialists.
Results: We found a similar success rate of over 80% in all questions asked to ChatGPT-3.5 and two independent emergency medicine specialists with at least 5 years of experience who did not know each other. ChatGPT-3.5 achieved a 100% success rate in all questions related to the General Overview for Current AHA Guideline, Airway Management, and Ventilation chapters in English.
Conclusions: Our study indicates that ChatGPT-3.5 provides similar accurate and up-to-date responses as experienced emergency specialists in the AHA 2020 Advanced Cardiac Life Support Guidelines. This suggests that with future updated versions of ChatGPT, instant access to accurate and up-to-date information based on textbooks and guidelines will be possible.
Revolutionizing Field Data Collection andManagement: The Role of PowerApps and RPA in Improving Service Quality, Enhancing Customer Experience, and Reducing Manual Effort
Authors: Potturu Sai Madhur 
Published: June 2023

Abstract
In this paper, I present a digital solution that leverages Microsoft PowerApps and Robotic Process Automation (RPA) to revolutionize field data collection and management in rural farms where internet connectivity is a challenge. The solution explores different approaches to capturing data offline and synchronizing it with a data source when the device regains connectivity. With the PowerApps application, field force team members can capture and store service order data on their mobile/tablet devices, both online and offline. The RPA solution retrieves the data from the database and automatically creates service orders in various systems. This paper explores the benefits of this digital solution in improving service quality, enhancing customer experience, and reducing manual effort.
Childhood trauma, psychache and depression: A Moderated Mediation Model
Authors: Chen Shufeng , Fu Tiantian , Wang Yiwen , Sun Guoxiao 
Published: June 2023

Abstract
Background: Childhood trauma is a potential threat to depression and can have a lifelong impact on the mental health of university students. Few studies have investigated the mediating and moderating variables that influence this relationship. Our study aimed to construct a moderated mediation model to explore the relationship between childhood trauma, psychache, ambivalence over emotional expression, physical activity, and depression in university students.
Methods: A cross-sectional study was conducted in three universities in Shandong, Liaoning, and Guizhou in China, recruiting 476 university students using self-report questionnaires. The moderated mediation model was examined using the SPSS PROCESS model 21.
Results: 1) Childhood trauma has a significant and positively associated with depression. 2) Psychache partially mediates the relationship between childhood trauma and depression in university students. 3) The overall indirect effect of the ambivalence over emotional expression, psychache, and physical activity in the mechanisms underlying childhood trauma and depression was 0.287, accounting for 61.59% of the total effect. 4) High ambivalence over emotional positively moderates the pathway between childhood trauma and psychache, whereas physical activity level negatively moderates the pathway between psychache and depression.
Conclusions: This study investigated the relationship between childhood trauma, ambivalence over emotional expression, psychache, physical activity, and depression in university students. Future interventions should focus on developing good emotional expression among university students, increasing opportunities for physical activity, and reducing psychache to reduce depression.
An Empirical Study on Cyber Crimes and Cybersecurity Awareness
Authors: Mupila Francis K. , Gupta Himanshu , Bhardwaj Akashdeep 
Published: June 2023

Abstract
With the boom in the digital world today, cybercriminals have taken the Internet as their playground. The Internet's crimes have increased compared to previous years, and cybersecurity awareness must be paramount. This paper uses statistical correlation and regression techniques to study cybercrime rates and cybersecurity awareness levels empirically. Our analysis reveals a significant correlation between cybercrime rates and low cybersecurity awareness levels, suggesting that a lack of awareness contributes to higher cybercrime rates. We also find that age, occupation, and education level are significant predictors of cybersecurity awareness, with younger individuals and those in higher-paying professions having higher awareness levels. These findings suggest that improving cybersecurity awareness among individuals and organisations is crucial to preventing cybercrime. Policy recommendations include increasing awareness-raising activities targeted toward older age groups and developing education and training programs targeting individuals in lower-paying occupations—cyber-attacks targeting the less aware and vulnerable.
A study about the awareness of medical college students about donating corneal tissue after death
Authors: sasa Mohammad , Kassab Abdulmunem , Suleiman Siham 
Published: June 2023

Abstract
Introduction:
Therefore, in order to avoid unethical practices, medical ethical guidelines were developed by several groups of experts, the most important of which were The WHO Transplantation Principles and the Barcelona Principles of the Global Alliance of Eye Bank Societies. It is crucial for medical students to have knowledge around the donation of corneal tissue and the laws that bind it.
Methods:
A questionnaire was developed by the research team for the purpose of this study. The questionnaire was initially designed by a focus group consisting of a group of practicing optometrists and public health researchers. Data was analyzed using spss21.0 software version (IBM Corporation, Armoc, New York, USA). Descriptive statistics were calculated, including frequencies and percentages, to summarize categorical data
Results:
The questionnaire was completed by 1500 participants among which 416 were males and 1084 were females.
Conclusion:
This study emphasized the need to implement educational programs to raise awareness of corneal donation and to encourage official registration of willing donors, which may reduce misunderstandings related to donation and increase the supply of tissues for local donors.
Examination of a Human Heart utilizing Virtual Reality, Additive Manufacturing and Computational Technologies
Authors: Charalampous Paschalis , Kladovasilakis Nikolaos , Zoumaki Maria , Kostavelis Ioannis , Votis Konstantinos , Petsios Konstantinos , Tzetzis Dimitrios , Tzovaras Dimitrios 
Published: June 2023

Abstract
Purpose In this paper, an innovative approach concerning the investigation of the human heart is introduced employing state-of-the-art technologies. The presented technological tools aim in the creation of an innovative digital environment, where gaining surgical experience and developing pre-operative strategies could be achieved without the risk and anxiety of an actual heart surgery.
Methods Sophisticated algorithms were developed in order to automatically reconstruct a 3D model of a human heart based on DICOM data and to segment the main parts that constitutes it. Taking into account the reconstructed 3D model, a diagnosis of the examined patient can be derived, where in the present study a Coarctation of the Aorta (CoA) clinical case was inspected. In addition, numerical approaches were considered that are able to simulate flows on complex shapes. Finally, a physical model was 3D printed via the MultiJet 3D Printing (MJP) process utilizing flexible materials.
Results The outcomes of the computation analysis coupled with the automatically reconstructed and segmented patient-specific 3D model are inserted in a Virtual Reality (VR) environment, where the clinicians can visualize the blood flow at the vessel walls and train on real-life medical scenarios, enhancing that way the procedural understanding prior to the actual operation. Moreover, the 3D printed heart possesses an adequate mechanical response replicating the mechanical properties as well as the geometrical characteristics of the investigated human heart.
Conclusions The present study introduced a robust software module for inspecting human hearts, aiding that way the medical doctors on the optimal preoperative assessment of patients with heart diseases using as input only the DICOM data of the examined patient.
Prioritization of micropollutants based on removal effort in drinking water purification treatment
Authors: Pronk Tessa E. , Fischer Astrid , van den Berg Annemijne E. T. , Hofman Roberta C. H. M. 
Published: June 2023

Abstract

A main focus of water managers with regard to micropollutants is the protection of aquatic ecology. However, micropollutants also have the potential to affect the production of clean drinking water. In this paper, we propose to consider the removal effort when assessing micropollutants with an ‘Effort Index’ (EI). Assessments using the EI show which micropollutants need more extensive monitoring or abatement because of their difficulty to be removed using low-effort water purification treatment techniques. For water containing mixtures of micropollutants, the averaged EI values can indicate overall water quality. Data on the removal by different purification treatment techniques are not necessarily available for all micropollutants. Therefore, a set of data-driven indicative removal rules is derived to quantify the relation between micropollutant properties and different drinking water treatment techniques. The indicative removal rules provide a rough indication of removability. As an illustration, the water quality of the river Rhine is evaluated between 2000 and 2018. The EI value shows that the Rhine contains increasingly more difficult-to-remove micropollutants. In total, 18 of those are labeled as particularly difficult-to-remove chemicals. These micropollutants are suggested as candidates for abatement to lower the required effort in drinking water production.
Synthesis and Evaluation of Thioamide and Bromo Derivatives of 1,3-Diphenylpropane-1,3-dione as 5α-Reductase Inhibitors
Authors: Fouad Marwa M. , Farag Ahmad M. , Ragab Eman A. 
Published: June 2023

Background:
1,3-Diphenylpropane-1,3-dione (1) is an acetylacetone β-diketone in which both of the methyl groups have been replaced with phenyl groups. It is a component of licorice root extract (Glycyrrhiza glabra) and has anti-mutagenic and anti-cancer properties. It functions as a metabolite, an anti-mutagen, and an anti-neoplastic agent. It is an aromatic ketone and a β-diketone. 1,3-Diphenylpropane-1,3-dione (1) is primarily used in PVC hard and soft materials, including plates, films, profiles, pipes, and fittings

Objectives:
This research aims to examine the utility of 1,3-diphenylpropane-1,3-dione (1) for the synthesis of a variety of new heterocyclic compounds, such as thioamide, thiazolidine, thiophene-2-carbonitrile, phenylthiazole, thiadiazole-2-carboxylate, 1,3,4-thiadiazole derivatives, 2-bromo-1,3-diphenylpropane-1,3-dione, new substituted benzo[1,4]thiazines, phenylquinoxalines, and imidazo[1,2-b][1,2,4]triazole derivatives of potential biological activity

Methods:
1,3-Diphenylpropane-1,3-dione (1) was used as a starting compound for the synthesis of 3-oxo-N,3-diphenyl-2-(phenylcarbonyl)propanethioamide (3) and 2-bromo-1,3-diphenylpropane-1,3-dione (25), which can be used for further preparations. The 5α-reductase inhibitor activity of some of the synthesized compounds was also tested in vivo; the ED50 and LD50 data were established,

Results:
Using IR, 1H-NMR, mass spectroscopy, and elemental analysis, the structures of all produced compounds were elucidated. Some of these prepared compounds were reported as 5α-reductase inhibitors.

Conclusion:
New heterocyclic compounds can be formed via 1,3-diphenylpropane-1,3-dione (1), and some of these compounds can act as 5α-reductase inhibitors.
A Case Study on Bacteriological and Physiochemical Evaluation of Hospitals
Drinking Water in Pakistan
Authors: Bilal Muhammad , Khan Salma , Khan Muhammad Iqbal , Ali Javed , Wahab Abdul , Ismail Muhammad , Akhtar Kalsoom , Bakhsh Esraa M. , Khan Sher Bahadar 
Published: June 2023

Background:
Seventy percent of the Earth is covered by water, out of which only 1% is fresh
water. This fresh water can be used for drinking and other domestic uses. However, a drastic increase in
the industrial revolution resulted in depletion of the reservoirs and contamination of the potable fresh
water. Around 3.4 M deaths per annum occur as a result of waterborne diseases.

Objectives:
Therefore, the aim of this study is to establish physical, chemical, and biological parameters
for evaluating contamination in the drinking water of hospitals in the Bannu and Kohat divisions, Khyber
Pakhtunkhwa, Pakistan.

Method:
Eleven different hospitals were selected for the collection of water samples. Total solids, total
dissolved solids, electrical conductivity, and pH were considered significant physical metrics for this
study. The essential and heavy metals were also quantified. Furthermore, biological parameters such as
Escherichia coli (E. coli) content of drinking water were also studied by using membrane filtration.

Results:
The results show that E. coli were detected in nine out of the eleven water samples. Moreover,
some of the physicochemical parameters were not within guideline limits specified by the World Health
and other international organizations.

Conclusions:
E coli in most of the hospital drinking water was more than the WHO permissible level of
the physiochemical parameters. This will have adverse effects on the health of patients which is a serious
threat for the population. Therefore, this investigation provides useful information to the government to take
special precautions for maintaining the quality of the potable water in government and private hospitals.
Dose-response Analysis in Hepatic Tumors Treated with 90Y-TARE
According to a Personalized Dosimetric Workflow: Preliminary Results
Authors: Milano Alessia , Capotosti Amedeo , Zagaria Luca , Perotti Germano , Rizzo Alessio , Longo Valentina , De Leoni Davide , Moretti Roberto , Breschi Laura , Meffe Guenda , Placidi Lorenzo , Cusumano Davide , Cerrito Lucia , Annunziata Salvatore , Iezzi Roberto , Indovina Luca 
Published: June 2023

Background:
Transarterial Radioembolization (TARE) is a widespread radiation therapy
for unresectable hepatic lesions, but a clear understanding of the dose-response link is still
missing. The aim of this preliminary study is to investigate the role of both dosimetric and clinical
parameters as classifiers or predictors of response and survival for TARE in hepatic tumors and to
present possible response cut-off.

Methods:
20 patients treated with glass or resin microspheres according to a personalized workflow
were included. Dosimetric parameters were extracted from personalized absorbed dose maps
obtained from the convolution of 90Y PET images with 90Y voxel S-values.

Results:
D95 ≥ 104 Gy and tumor mean absorbed dose MADt ≥ 229 Gy were found to be optimal
cut-off values for complete response, while D30 ≥ 180 Gy and MADt ≥ 117 Gy were selected as
cut-off values for at least partial response and predicted better survival. Clinical parameters Alanine
Transaminase (ALT) and Model for End-Stage Liver Disease (MELD) didn’t show sufficient
classification capability for response or survival.

Concusion:
These preliminary results highlight the importance of an accurate dosimetric evaluation
and suggest a cautious approach when considering clinical indicators. Dosimetric cut-off values
could be a support tool in both planning and post-treatment phases. Larger multi-centric randomized
trials, with standardized methods regarding patient selection, response criteria, Regions
of Interest definition, dosimetric approach and activity planning are needed to confirm these promising
results.