bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A011: Whole genome sequencing of the Alabama Hereditary Cancer Cohort to identify African American breast cancer genetic risk variants
Authors: LoBue Troy , Mcneely Isaac , Merner Nancy 
Published: January 2023

Abstract
Regardless of having higher rates of triple-negative breast cancer (TNBC) and breast cancer-related deaths, African Americans are drastically understudied in hereditary breast cancer research. Our group has established the Alabama Hereditary Cancer Cohort to carry out next-generation sequencing (NGS) to address this gap. These efforts aim to identify inherited breast cancer risk variants in African Americans. Interestingly, African American TNBC tumors have been investigated through NGS, identifying somatic mutations unique to African American breast cancer. Now, African American-specific variants associated with inherited risk need to be identified, including those in genes harboring somatic mutations in African American TNBC. This study carried out whole genome sequencing (WGS) to investigate inherited African American breast cancer risk. All coding and non-coding regions of the nuclear genome and the entirety of the mitochondrial genome were explored, all of which can play a role in hereditary breast cancer risk. Individuals provided a blood or saliva sample for DNA extraction upon study consent. Subsequently, paired-end Illumina sequencing was carried out. Fastq files were trimmed using Trimmomatic and further processed according to the Genome Analysis ToolKit Best Practices, resulting in variant call format (VCF) files. Coding, non-coding, and mitochondrial regions were individually extracted using VCFtools and UCSC Table Browser tracks. Coding and mitochondrial variants were annotated using Annovar and MSeqDR, respectively. Coding variants were further filtered for minor allele frequency (MAF) classes (i.e., rare and low-frequency) and mutation type (i.e., protein-truncating variants; PTVs) using R (v. 4.2). Preliminary WGS data of 60 African American hereditary breast cancer cases have identified statistically significant rare and low-frequency PTVs in genes reported to harbor somatic mutations exclusively in African American TNBC tumors. Furthermore, we have identified variants in prostate cancer susceptibility genes that are statistically associated with African American breast cancer risk. We have also identified multiple variants in the mitochondrial genome that are statistically linked to breast cancer risk, some African American-specific. Our data shows that WGS is an invaluable tool for identifying breast cancer susceptibility variants. Further sequencing and functional analyses will validate our preliminary findings.
Citation Format: Troy LoBue, Isaac Mcneely, Nancy Merner. Whole genome sequencing of the Alabama Hereditary Cancer Cohort to identify African American breast cancer genetic risk variants [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A011.
Abstract A117: Barriers to lung cancer screening in rural populations: A systematic review
Authors: Schwenk Alysa , Laynor Gregory , Leader Amy 
Published: January 2023

Abstract
The U.S. Preventive Services Task Force currently recommends low-dose computed tomography for those at risk of lung cancer, the leading cause of all cancer deaths in the United States. While this screening has been proven to be effective at detecting lung cancer and reducing mortality, some populations, such as those living in rural areas, may encounter unique barriers to screening. To date, multiple studies have examined barriers to lung cancer screening among rural populations. This rapid review of the literature utilized a systematic approach to identify and summarize current barriers to lung cancer screening in rural populations. Using a precise search strategy, 354 articles from PubMed and Scopus were identified and screened via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) process. Upon completion, 8 articles were included in the review. The majority of the studies focused on geographic access as a barrier, while one study focused on cognitive barriers to lung cancer screening. While geographic barriers focused on distance to the screening site as a barrier, cognitive barriers focused on knowledge, attitudes, awareness, the healthcare system (e.g., physician maldistribution, scheduling conflicts, etc.), and cost. Additionally, while these studies did identify barriers, there was little variation amongst studies, and no studies surveyed at risk individuals from rural areas. These findings indicate that more research needs to be conducted in identifying barriers to lung cancer screening. Once barriers among rural populations are known, community-based interventions to reduce those barriers will lead to increases in lung cancer screening in vulnerable rural populations.
Citation Format: Alysa Schwenk, Gregory Laynor, Amy Leader. Barriers to lung cancer screening in rural populations: A systematic review [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A117.
Abstract A118: Uptake of cervical cancer screening services in urban Zimbabwe: Healthcare provider perspectives
Authors: Shato Thembekile , Nwaozuru Ucheoma , Boakye Eric Adjei , Fu Qiang John , Iwelunmor Juliet , Kuhlmann Anne Sebert 
Published: January 2023

Abstract
Background: In sub-Saharan Africa, Zimbabwe is among the top 6 countries with the highest cervical cancer incidence and mortality rates. Despite the disproportionate and growing burden, uptake of cervical cancer screening remains low. Little is known about the perceptions of healthcare providers who play a vital role in the provision and implementation of cervical cancer screening. This study explores healthcare provider perceptions of the factors that influence the uptake of cervical cancer screening in Zimbabwe. Methods: One-on-one in-depth interviews were conducted with healthcare providers currently or previously involved in cervical cancer prevention programs at select hospitals and clinics in Harare and Chinhoyi – two urban cities in Zimbabwe. A deductive thematic approach was used to analyze qualitative data to understand factors influencing the provision and uptake of cervical cancer screening. Results: We conducted 21 interviews with healthcare providers working in cervical cancer prevention for an average of 4 years. Three main themes related to the provision of cervical cancer screening were funding availability through donor support, demand of screening services, and availability of technical and human resources. Experiencing symptoms and no-cost screening services were perceived as facilitators for uptake of cervical cancer screening, while lack of adequate health education about cervical cancer and misconceptions about the screening procedure and outcomes were perceived as barriers to uptake of screening. Majority of the providers recommended increased sensitization and health education through various platforms; outreach initiatives; and training of more healthcare providers to conduct cervical cancer screening. Conclusion: This study contributes to a holistic understanding and identification of intervention points to effectively increase uptake of cervical cancer screening. Multi-level strategies promoting awareness of cervical cancer screening and strengthening healthcare systems may contribute significantly to increasing cervical cancer screening rates which in turn will lead to reducing the burden of cervical cancer in Zimbabwe.
Citation Format: Thembekile Shato, Ucheoma Nwaozuru, Eric Adjei Boakye, Qiang John Fu, Juliet Iwelunmor, Anne Sebert Kuhlmann. Uptake of cervical cancer screening services in urban Zimbabwe: Healthcare provider perspectives [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A118.
Abstract A131: The effective of mHealth intervention on hepatitis B virus screening among Asian Americans: A scoping review
Authors: Zhu Di , Zisman-Ilani Yarra , Roth Stephanie , Zhu Lin , Ma Grace X. 
Published: January 2023

Abstract
Introduction. Hepatitis B virus (HBV) is one of the major health threats causing cancer. Asian Americans are especially vulnerable to HBV infection risk compared to other racial/ethnic groups in America. New mHealth interventions have promising potential to save lives by increasing HBV screening among racial/ethnic minority groups, but its scope, range, and uptake among Asian Americans are not clear. This study aims to scope the literature describing the research of mHealth interventions on HBV screening among Asian Americans. Methods. A scoping systematic review search is conducted in PubMed and Embase. Eligible studies focus on Asian Americans aged 18 years or older who have participated in an mHealth Hepatitis B screening. All types of mHealth interventions on HBV are relevant (e.g., health apps and text messages). Studies not published in the English language will be excluded. Results. A review protocol is developed. Next. We will covert our search strategy to Embase, Medline, and other databases to get more records. At present, title and abstract screening are under development. After that, full-text screening, data extraction, data management, quality assessment, and data synthesis and analysis will be conducted. Initial results will be discussed. Potential impact. The results of this scoping and systematic review could improve our understanding of mHealth HBV screening use and uptake among Asian Americans and inform the development of a future intervention to encourage mHealth HBV screening for this patient population. In the long run, it could encourage the development of a future tailored mHealth intervention to facilitate the HBV screening uptake among Asian Americans
Citation Format: Di Zhu, Yarra Zisman-Ilani, Stephanie Roth, Lin Zhu, Grace X. Ma. The effective of mHealth intervention on hepatitis B virus screening among Asian Americans: A scoping review [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A131.
Abstract B004: Decídetexto: A mobile smoking cessation intervention among Puerto Ricans in the US
Authors: Hernández-Torres Ruthmarie , Cartujano-Barrera Francisco , Chavez-Iñiguez Arlette , Ossip Deborah , Rivera M. Patricia , Castro-Figueroa Eida M. , Cupertino Ana Paula 
Published: January 2023

Abstract
Background: Puerto Ricans report the highest smoking rate (28.5%) among women and men compared to other Latino subgroups. Puerto Rican smokers are less likely to use smoking resources and quit smoking. Objective: To assess smoking behaviors and sociodemographic characteristics related to smoking cessation outcomes among Puerto Ricans in the United States. Methods: The study is a secondary analysis of the Decídetexto text message smoking cessation clinical trial, including 457 Latino smokers with access to nicotine replacement therapy (NRT). The study included 111 Puerto Rican smokers (Decídetexto: 49; control: 62). Pearson Chi-squares were used for categorical dependent variables and point biserial correlation for continuous dependent associations with smoking cessation outcomes assessed at 6mo (quit attempts, number of cigarettes per day, quit attempts, and self-reported cessation). Results: Participants were largely middle-aged (49.6 years), women (52.3%), and more than half (69.4%) preferred the Spanish language. The mean number of cigarettes per day was 11.55 (SD=6.85), and they reported an average of 2.49 (SD=5.088) quit attempts in the last year. The majority of reported using menthol cigarettes (73.9%) and previously using medication (58.6%) and e-cigarettes (55%). A six-month, 7-day self-reported smoking abstinence was 24.3% (32.7% for Decídetexto and 17.7% for control). Previous quit attempts and education were significantly associated with the self-reported 7-day abstinence at six months year (rpb = .252, n = 111, p = .008; Χ2(4) = 10.772, p= .029 ). Age, gender, language preference, employment status, cigarettes per day, menthol cigarettes, and e-cigarette use were not related to 7-day self-reported smoking cessation. Conclusion: Decídetexto mobile smoking cessation is likely to facilitate smoking cessation among Puerto Ricans living in the US. Results from the present study will inform future randomized clinical trials for the understudied Puerto Rican Latino population with the highest smoking rate.
Citation Format: Ruthmarie Hernández-Torres, Francisco Cartujano-Barrera, Arlette Chavez-Iñiguez, Deborah Ossip, M. Patricia Rivera, Eida M. Castro-Figueroa, Ana Paula Cupertino. Decídetexto: A mobile smoking cessation intervention among Puerto Ricans in the US [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B004.
Abstract B063: C-STEPS- A Cancer Research Education Program for Undergraduates
Authors: Pimentel Monica F. Asencio , Sheche Judith , Mishra Shiraz I. , Kano Miria , Rodman Joseph 
Published: January 2023

Abstract
As a nation, we have made impressive advances in cancer prevention and control, reflected in improvements in incidence, mortality, stage of disease diagnosis, and survival. These gains are attributed, in part, to significant advances in cancer control and population sciences (CCPS) research in genomic science, behavioral interventions, cancer care delivery, and survivorship. However, minority status, rurality, literacy, and socio-economics continue to predict cancer health disparities. Continued progress, new scientific discoveries, and interventions that lead to health equity require a well-trained cancer and health focused workforce. The goal of the Cancer Research—Scholarship and Training Experiences in Population Sciences (C-STEPS) is to increase the biomedical and behavioral research workforce by providing specialized and experiential cancer research curricula and a mentored research experience to undergraduate students, held over 10-weeks during the summer on the University of New Mexico campus. C-STEPS is designed to facilitate and support undergraduates in their completion of a degree in a Science, Technology, Engineering, Mathematics, and Health (STEM-H) field and to facilitate their selection of, and application to, graduate or professional schools, while encouraging their interests in cancer research careers. A pre and post-assessment tool was used to evaluate and measure C-STEPS student mentees’ interests, preparedness, progress, and knowledge gained. In addition, the evaluation surveys consisted of objective items rated on Likert scales in the domains of program logistics and career impact. At the end of the program, all C-STEPS research mentors completed a qualitative and quantitative survey to identify mentees’ research skills, engagement, and professionalism. Summary statistics were computed for each quantitative item and presented as summary means, and themes were gleaned from qualitative written comments. Overall satisfaction with the C-STEPS program is high. The majority of student mentees felt the program curriculum and instructions were clear, their mentors were of high caliber, and that they learned new research-related concepts and techniques. The mentors felt that mentees obtained new skills relevant to a career in research and gained experience necessary to attain future training and educational opportunities. Our analyses characterize the impact of the inaugural C-STEPS program and adds to the knowledge base of evaluation of STEM-H research education programs.
Citation Format: Monica F. Asencio Pimentel, Judith Sheche, Shiraz I. Mishra, Miria Kano, Joseph Rodman. C-STEPS- A Cancer Research Education Program for Undergraduates [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B063.
Abstract B133: Understanding the barriers to and attitudes toward integrative oncology for African Americans with cancer
Authors: Williams Chanda L. , Piawah Sorbarikor , Atreya Chloe , Stanfield Dalila , Levine Kendall , Yang Adrienne 
Published: January 2023

Abstract
Despite modern advances in screening, diagnosis, and treatment, Black individuals in the United States remain disproportionately affected by cancer and have the highest mortality and lowest survival for most cancers. There is minimal data on the uptake and acceptability of integrative oncology among Black individuals, likely due to a lack of diversity in study participants, poor accrual, and racial/ethnic or cultural differences in the acceptability of study interventions/instruments. Research lacks the acceptability of complementary approaches for cancer prevention/disease modification or management of cancer/treatment-related side effects in this population. Results from this pilot will guide efforts to enhance the recruitment of Black individuals to integrative oncology programs. This study will provide data to support integrative oncology programs specifically for Black patients with cancer. Findings will also help guide future research on what modalities are most efficacious and recommendations to increase engagement in research for this patient population. Future research might also facilitate an understanding of the mechanisms of action involved with these interventions.
Citation Format: Chanda L. Williams, Sorbarikor Piawah, Chloe Atreya, Dalila Stanfield, Kendall Levine, Adrienne Yang. Understanding the barriers to and attitudes toward integrative oncology for African Americans with cancer [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B133.
Abstract C007: Reasons for pursuing genetic testing among young Black women with breast cancer
Authors: Roberson Mya L. , Reid Sonya , Pal Tuya 
Published: January 2023

Abstract
Introduction Genetic testing is an increasingly important part of cancer treatment for women with breast cancer diagnosed under age 45. There has been evidence about low testing uptake and barriers to genetic testing for eligible Black women but less is known about motivations for testing. The objective of this study was to assess reasons for pursuing genetic testing among young Black women with breast cancer. Methods Study participants were a population-based sample of self-identified Black women diagnosed with invasive breast cancer at or below age 50, recruited through the Florida and Tennessee state cancer registries. Participants were categorized into tested and not tested groups. Among the tested, participants were asked why they pursued testing and response options included to guide surgical decisions, chemotherapeutic decisions, radiation decisions, or to benefit family. Respondents were categorized into 4 groups: no motivation specified; treatment motivation only; family benefit motivation only; both treatment and family motivation. Logistic regression was used to estimate factors associated with type of motivation. Results In total, 175 women were eligible for inclusion, 135 women had received genetic testing, and 40 had not. Median age of breast cancer diagnosis was 43. Among tested women, 30 (22%) endorsed treatment motivation only, 69 (51%) endorsed family motivation only, and 31 (23%) endorsed both treatment and family motivation. Women who had daughters had higher odds of endorsing being motivated by family benefit (OR 3.87, 95% CI 1.98, 7.57). This relationship was not seen for having sons (OR 0.84, 0.49, 1.83), sisters (OR 0.78, 95% CI 0.34, 1.77) or brothers (0.87, 0.43, 1.73). Among the 40 women who did not receive genetic testing, 24 (60%) indicated a lack of testing recommendation. Conclusions In our investigation, we found that a greater number of Black women were motivated to pursue genetic testing because of the potential benefit to family members rather than to guide treatment decisions. This finding was especially pronounced among women who had daughters. The null relationship between having sons or either gender sibling and motivation driven by family benefit may reflect greater awareness of BRCA associations with female breast cancer and low awareness of male breast and other BRCA associated cancers. Our findings suggest that conversations around the importance of genetic testing may need to go beyond the importance of guiding treatment decisions and include discussions around the potential benefit for family members.
Citation Format: Mya L. Roberson, Sonya Reid, Tuya Pal. Reasons for pursuing genetic testing among young Black women with breast cancer [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C007.