bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Vitamin B12 intake With kidney stone prevalence
Authors: Liu chunxiang , Wang Bo , Wang Haoyu , Guo Zheng , Wang Song , Wang Yuchao , Sun Wei , Liu Xiaoqiang , Sun Daqing 
Published: December 2022

Abstract
Background: The associations of vitamin B12 intake with kidney stones prevalence remain unclear. The purpose of this research was to investigate whether or not there is a connection between kidney stones and vitamin B12 use.
Methods: To investigate the connection between the amount of vitamin B12 consumed and the incidence of kidney stones, we carried out a cross-sectional study using data from the National Health and Nutrition Examination Survey from 2015-2016 and 2017-2018, which included a total of 4599 participants. The survey was carried out in the United States.
Results: A logistic regression model adjusted for covariates in all individuals revealed that the second quartile (OR: 0.879, p = 0.489), third quartile (OR: 0.708, p = 0.069), and fourth quartile (OR: 0.641, p = 0.018) of Vitamin B12 substantially reduce kidney stone risks. Vitamin B12 consumption levels had a U-shaped connection with kidney stone risk in the 20-34 age group, with the ORs of kidney stone risk in the second, third, and fourth levels of Vitamin B12 being 0.841 (P = 0.711), 0.345 (P = 0.025), and 1.767 (P = 0.147), respectively. However, these results were not found in the other age group; for people aged 49–63, when the concentration of vitamin B12 intake was 5.84~62.71mcg/d, the OR value of kidney stones was 0.279 (0.126-0.615), and their was no significant difference in OR values between 34-49 years old and 63-80 years old. In the gender subgroup analysis, when the vitamin B12 intake was 5.84~62.71mcg/d in men and 3.5~5.84mcg/d in women, the use of vitamin B12 has an inverse relationship with the odds ratio of developing kidney stones.
Conclusions: The quartile of vitamin B12 consumption has been shown to have an inverse relationship with the chance of developing kidney stones. Gender subgroup analysis also found a negative correlation. The best vitamin B12 intake associated with the lowest OR of kidney stones was 5.84~62.71mcg/d in males and 3.5~5.84mcg/d in females. The OR of kidney stones in people aged 49 to 63 years old was the lowest, which was 5.84~62.71mcg/d.
In-Silico analysis of potential antidiabetic phytoconstituents from Manilkara hexandra against mitoNEET
Authors: Katolkar Parimal , Motghare Apeksha , Baheti Jagdish , Lichade TIna 
Published: December 2022

Abstract
Objective
Insulin deficiency or malfunction leads to diabetes mellitus, a serious metabolic disorder. Once more, studies on the use of medicinal plants to treat diabetes are ongoing. Many common drugs have been made from prototypical substances derived from medicinal plants. Our work included in-silico testing of Manilkara hexandra phytoconstituents for anti-diabetic activity.
Design:
The pattern of interaction between the phytoconstituents from the Manilkara hexandra plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 3REE). Later, the toxicity and pharmacokinetic profile were screened using SwissADME and pkCSM.
Results
The docking data reveal that compared to the common medication metformin (-4.1 kcal/mol); quercetin (-7.1 kcal/mol), kaempferol (-7.1 kcal/mol), P-coumaric acid (-6.2 kcal/mol), and cinnamic acid (-6.0 kcal/mol) have the greatest binding affinity for mitoNEET for antidiabetic action. According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds.
Conclusion
The binding potential of phytoconstituents with an eye on antidiabetic activities produced positive results. It provides vital information on clinical treatment and pharmacological research while advocating the use of Manilkara hexandra.
Spin Wave Spectra in Pseudoperovskite Manganites with Superexchange Interaction Competition
Authors: Gonchar Liudmila E. 
Published: December 2022

Abstract
In compounds La1/3Ca2/3MnO3 and BiMnO3, a calculation of spin-wave dispersion dependences along pseudoperovskite directions of reciprocal space is made. The model includes orbitally-dependent superexchange interaction and single-ion anisotropy. Considered compounds present competing exchange interactions within magnetic unit cell because of orbital or charge-orbital ordering. The nearest neighbor superexchange interaction is taken into account. The magnetic structure and dispersion dependences of spin waves frequencies are calculated within the framework of regular multi-sublattice model. The peculiarities of frustrated magnetic spin-wave spectra are found. It is shown, that crossing and splitting of spin-waves branches in non-symmetric points of magnetic Brillouin zone is a common feature of the spectra due to exchange competition. The band structure of Γ-point spectra for both compounds are predicted.
MgrB mutations causing colistin resistance in ST11 and ST15 Klebsiella pneumoniaes in a tertiary teaching hospital in China
Authors: zhao shulong , song shuang , guo yi , jiang fei , Hao Tingting , wang Liang , kang Haiquan 
Published: December 2022

Abstract
Introduction:Colistin-resistant carbapenem-resistant Klebsiella pneumoniae (ColR-CRKP) is a threat to public health safety. The main cause of polymyxin resistance is a change in the negative charge and L-Ara-N and PEtN molecules on the cell membrane, which leads to a decrease in the affinity of polymyxin for the strain.
Methodology: In this study, (ColR-CRKP) isolates and clinical data were collected from a tertiary teaching hospital in China .Testing of antimicrobial susceptibility explained on the European Committee on Antimicrobial Susceptibility Testing criteria (EUCAST), Mutations and expression of drug-resistant genes were detected by PCR and RT-PCR. Genotyping of isolates analysised by MLST and PFGE.
Results:Fourteen ColR-CRKP strains were collected and all isolates were resistant to colistin and most other clinical antibiotics (except tigecycline and cotrimoxazole), and were divided into 6 different PFGE clusters, and most strains clustered in B,C,D groups. Base mutations in the mgrB gene that can lead to changes in amino acid sequence were found in all 14 strains. Missense mutations a55→t translated into S32C were found in 85.7% isolates (n=12; KP1-9, KP11-12 and KP14). The expression level of mgrB gene was decreased in all ColR-CRKP strains.
Conclusions:Third-generation cephalosporins and enzyme inhibitors, as well as carbapenems, may be causative for the mutation. The new challenge for the treatment of ColR-CRKP requires broader attention.Our study showed that mutations in the mgrB gene can lead to the development of polymyxin resistance in in ST11 and ST15-KPC-2-producing K. pneumoniae in this region.
Changes in body mass index, weight, and waist-to-hip ratio over five years in HIV-positive individuals in the HIV Heart Aging Study compared to the general population
Authors: Mavarani Laven , Albayrak-Rena Sarah , Potthoff Anja , Hower Martin , Dolff Sebastian , Sammet Stefanie , Maischack Felix , Schadendorf Dirk , Schmidt Börge , Esser Stefan 
Published: December 2022

Abstract
Purpose:
Overweight and obesity have increased in people living with HIV (PLH). Our study evaluated weight, body-mass-index (BMI), and waist-to-hip ratio (WHR) change over 5 years of follow-up in PLH compared to the general population.
Methods:
HIV-positive participants in the HIV Heart Aging (HIVH) study were matched 1:2 by age and sex with HIV-negative controls of the population-based Heinz Nixdorf Recall (HNR) study. Both studies were recruited in the German Ruhr area. The association between HIV and weight, BMI, and WHR changes were examined using linear regression. Regression models were adjusted for parameters potentially affecting weight gain.
Results:
The matched HIVH and HNR participants (N = 585 and N = 1170, respectively; 14.7% females) had a mean age of 55 years at baseline. Despite the lower baseline weight (6 kg, 95%-CI: -7.46 to -4.59), the linear regression showed greater absolute and relative weight and BMI increases within 5 years in HIVH compared to HNR. Adjusting the linear regression models for smoking amplified that HIVH had a higher absolute and relative weight difference of 0.7 kg or ~ 1% compared to HNR within 5 years (95% Cl: 0.1 to 1.3 and 0.2 to 1.6, respectively). Adjusting for HDL, LDL, systolic blood pressure, and diabetes mellitus did not affect the results.
Conclusions:
PLH had lower weight than the general population at baseline and after 5 years, but experienced greater increases in body weight after 5 years. WHR change after 5 years was lower in PLH compared to the general population, despite a higher WHR at baseline.
Management of complex pelvic-perineal soft tissue infection in open pelvic fractures: Comparison between conventional and modified instillation negative-pressure wound therapy
Authors: Choi Donghwan , Cho Won Tae , Song Hyung Keun , Kwon Junsik , Kang Byung Hee , Jung Hohyung , Kim Min Ji , Jung Kyoungwon 
Published: December 2022

Abstract
Background
Open pelvic fractures are associated with pelvic-perineal soft tissue injuries and pelvic infections as late complications. The study aimed to analyse and compare the clinical results and medical costs of the conventional and modified instillation negative-pressure wound therapy (cNPWT and m-iNPWT, respectively).
Methods
This retrospective study compared the outcomes of cNPWT and m-iNPWT for soft tissue management in patients with open pelvic fractures. We analysed the Injury Severity Score (ISS), hospital stay, medical costs, number of NPWT, time required to reach definite wound coverage, and occurrence of complications.
Results
Seventeen patients with open pelvic fractures were treated with NPWT. The median ISS (interquartile range) for m-iNPWT and cNPWT were 40 (26–48) and 43 (35–43), respectively. The numbers of NPWT changes were 6 (3–8) for m-iNPWT and 21 (20–32) for cNPWT. The time to wound coverage for patients who underwent m-iNPWT and cNPWT was 30 and 49 days, respectively. The overall medical costs of m-iNPWT and cNPWT were 80076 and 248395 USD. The hospital and intensive care unit (ICU) stay was 53 (41–70) and 12 (5–26) days for m-iNPWT and 167 (107–284) and 43 (23–151) days for cNPWT. One patient receiving cNPWT died of pelvic sepsis during ICU treatment.
Conclusions
Our study findings indicate that m-iNPWT would be a feasible method for complex pelvic soft tissue infection in open pelvic fractures to reduce complication rates, hospital stay, and medical costs.
Comparison of middle cerebral artery occlusion models conducted by Koizumi and Longa methods: A systematic review and meta-analysis of rodent data
Authors: Li Yong , Tan Li , Yang Caixia , He Liying , Deng Bowen , Huang Xianzhi , Liu Sijing , Liu Lin , Wang Jian , Guo Jinlin 
Published: December 2022

Abstract
Ischemic stroke in rodents is usually induced by intraluminal middle cerebral artery occlusion (MCAO) via common carotid artery (CCA) plugging filament invented by Koizumi et al (MCAO-KM), or external carotid artery (CCA) plugging filament created by Longa et al (MCAO-LG). To date, a systematic comparison between the two methods remains missing. Here, we performed a meta-analysis in terms of model establishment, cerebral blood flow (CBF), and cerebral ischemia-reperfusion injury (CIRI) between of them. Literature mining suggests that MCAO-KM brings shorter operation time (p = 0.007), higher probability of plugging filament (p < 0.001) and molding establishment (p = 0.006), lower possibility of subarachnoid hemorrhage (SAH) (p = 0.02), larger infarct volume (p = 0.003), and severer brain edema (p = 0.002) and neurological deficit (p = 0.03). Nevertheless, MCAO-LG shows more adequate CBF after ischemia-reperfusion (p < 0.001), higher model survival rate (p = 0.02), and greater infarct rate (p = 0.007). In conclusion, the MCAO-KM method is simple to operate with high modeling success rate, and it is suitable for the study of brain edema under long-term hypoperfusion, the MCAO-LG method is highly challenging for novices, and it is suitable for the study of CIRI caused by acute ischemia-reperfusion. These findings are expected to benefit in the selection of intraluminal filament MCAO models prior to undertaking ischemic stroke preclinical effectiveness trials.
Limitations on knowledge of autoimmune encephalitis and barriers to its treatment among neurologists: a survey from western China
Authors: Li Aiqing , Guo Kundian , Liu Xu , Gong Xue , Li Xingjie , Zhou Dong , Hong Zhen 
Published: December 2022

Abstract
Background
Autoimmune encephalitis (AE) is a group of severe antibody-mediated brain diseases, which has developed rapidly over the past decade. However, the knowledge level of AE and barriers to effective treatment among neurologists remains unstudied.
Methods
We conducted a questionnaire survey among neurologist in western China on knowledge of AE, treatment practices, and perspectives on barriers to treatment.
Results
A total of 1113 neurologists were invited and 690 neurologists from 103 hospitals completed the questionnaire with a response rate of 61.9%. Respondents correctly answered 68.3% of medical questions about AE. Some respondents (12.4%) never assayed for diagnostic antibodies if patients had suspected AE. Half (52.3%) never prescribed immunosuppressants for AE patients, while another 7.6% did not know whether they should do so. Neurologists who never prescribed immunosuppressants were more likely to have less education, a less senior job title, and to practice in a smaller setting. Neurologists who did not know whether to prescribe immunosuppressants were associated with less AE knowledge. The most frequent barrier to treatment, according to respondents, was financial cost. Other barriers to treatment included patient refusal, insufficient AE knowledge, lack of access to AE guidelines, drugs or diagnostic test, etc.
Conclusions
Neurologists in western China lack AE knowledge. Medical education around AE is urgent needed and should be more targeted to individuals with less educated level or working in non-academic hospitals. Policies should be developed to increase the availability of AE related antibody testing or drugs and reduce the economic burden of disease.
Network Accelerator for Parallel Discrete Event Simulations
Authors: Karaca O. Volkan , İmre Kayhan M. , Alkar Ali Ziya 
Published: December 2022

Abstract
The simulation time of parallel and distributed discrete event simulation is the heart rate for as-fast-as execution schemes. Agreeing upon a global simulation time and distributing it to the simulation processes can be improved by exploiting or redesigning the network hardware. In this paper, we present such an approach that offloads simulation time calculations to network switches in order to speed up the steps where time advance requests are made and time advance grants are waited. By reducing the waiting time for time advancement, we aim to improve the overall performance of the parallel simulations. The measurements from the FPGA-based hardware setup and the results from our network simulations show that overall performance can be improved when time management calculations are offloaded to the network switches. Additionally, the transient message problem is also solved within the network by not allowing the time control messages to bypass the time-dependent events. The network acceleration of the region-based event distribution is also studied, and offloading the region matching tasks to the network switches is found to be feasible to reduce the costs of node-based calculations, especially for fast-moving regions. In this study, we consider High-Level Architecture (HLA) for simulation infrastructure and fat tree topology for high-performance networking.
Batroxin I: A novel bradykinin-potentiating peptide with cytotoxic activity isolated from Bothrops atrox snake venom
Authors: Cintra Adélia Cristina Oliveira , Costa Tássia Rafaella , Cezarette Gabriel Neves , Castro Fabíola Attié , Pimenta Daniel Carvalho , Sampaio Suely Vilela 
Published: December 2022

Abstract
Venom peptides are interesting molecular models for the development of biotechnological strategies applicable in generating therapeutic agents and/or experimental tools for basic and applied research. The present study aimed to search for peptides from Bothrops atrox snake venom with anticancer potential activity against HepG2 liver tumor cell line, determine their cytotoxic action, and analyze the structure-function relationship. The novel peptide Batroxin I (M.W. 1.38 kDa) was isolated by molecular exclusion and reversed phase chromatography methods. The Batroxin I presented a selective cytotoxicity towards tumor cells, reducing the viability of HepG2 cells by 94.6% with IC50 of 0.72 µg/mL, and showing a low toxicity against peripheral blood mononuclear cells. Analysis of the apoptotic and necrotic peptide effects revealed that it induced apoptosis by intrinsic pathway activation. The amino acid sequence of Batroxin I was determined by de novo sequencing as < EKWPRPDAPIPP (where < E = pyroglutamic acid); hence, it is an unpublished peptide that belongs to the class of bradykinin-enhancing peptides and cell penetration peptide. This is one of the first reports on the cytotoxic antitumor activity of a bradykinin-enhancing peptide. Our results indicate that this peptide could serve not only as a template for the development of new drugs, but also as an adjuvant to less effective marketed drugs to treat cancer and other diseases.
A case report of an indium lung with progressive emphysema and fibrosis that underwent unilateral lung transplantation 20 years after the end of the exposure
Authors: Inoue Chihiro , Ohkouchi Shinya , Chonan Tatsuya , Amata Atsuko , Hirama Takashi , Saito-Koyama Ryoko , Kawabata Yoshinori , Suzuki Takashi , Okada Yoshinori , Tanaka Akiyo , Kurosawa Hajime 
Published: December 2022

Abstract
Background:
Indium lung is characterized by interstitial pneumonia and/or emphysema, which occurs in indium-tin oxide (ITO) workers. Indium lung is now known to progress after stopping exposure to ITO, but the long-term influences of ITO remain unclear.
Case presentation:
A 47-year-old, male never-smoker, who was engaged in an ITO manufacturing process for 8 years. Emphysema was indicated by a medical check-up for ex-ITO workers, and the subject was diagnosed with indium lung. He underwent partial lung resections for pneumothorax twice, and obstructive pulmonary dysfunction progressed over the years. The subject underwent right single lung transplantation 20 years after ITO exposure. Pathologically, his lung showed severe distal acinar emphysema and honeycomb change. Fibrosis and destruction of the lung tissue significantly progressed compared to the previous partial resections. Scanning electron microscopy combined with energy dispersive spectroscopy revealed that the deposited particles contained indium and tin. After transplantation, his respiratory function was improved.
Conclusions: In this case, ITO resided in the lung tissue for 20 years, and lung tissue destruction continued to progress. Careful medical follow-up is recommended for ITO workers even if they are asymptomatic.
Impact of transparency and disclosure on the dividend distribution of Indian banks
Authors: Bhimavarapu Venkata Mrudula , Rawal Aashi , Singh Kuldeep , Pinto Geetanjali , Rastogi Shailesh 
Published: December 2022

Abstract
This paper seeks to evaluate the influence of transparency and disclosure policies (td) on the dividend distribution decision of Indian banks. Further, it also evaluates the role of shareholder activism (sha) as a moderator on the relationship between td and dividends. To conduct this study, secondary data is collected from all nationalised banks in India for the period 2010-2019. Panel data model (PDM) is employed to analyse this data. This paper finds that: 1) There exists a significant linear association among td and dividend payout decision; 2) There also exists a non-linear association among td and equity dividends; 3) A negative moderating impact of sha is present in the association between td and equity dividends. These findings provide further insights into dividend distribution policy for the banks which would help the researchers, investors and companies working in different economies worldwide.
As per our knowledge, no such study has been carried out so far to investigate the non-linear association between the td and dividends and also demonstrate the role of shareholder activism (sha) as a moderator on the relationship among them for banks. Nevertheless, our study has considered only the banking sector and we have only investigated the role of sha as a moderator on the relationship between td and dividends.
JEL Classification Code: G21; G34; G38
Enhancement of NK cell proliferation by activation pre-processing of autologous feeder cell before irradiation
Authors: Koh Eun-Kyoung , Lee Hong-Rae , Son Woo-Chang , Park Ga-Young , Bae JaeHo , Park You-Soo 
Published: December 2022

Abstract
Background
Natural killer (NK) cells play a crucial role in early immune defenses against transformed cells and are used in therapeutic strategies for cancer. However, it is hard to sufficiently obtain high-purity activated NK cells for clinical application. The function of NK cells depends on the balance of activation and inhibitory signals. It is more powerful and diverse stimuli are required to increase the function of NK cells. Radiotherapy modulates the expression of various immunomodulatory molecules that recruit and activate NK cells. NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) is one of the most potent cytotoxic effects of NK cells against target cancer cells.
Methods
To generate activated and irradiated autologous PBMCs, cytokine and monoclonal antibody stimulation followed by ionizing radiation. Expanded NK cells were cultured for 21 days using activated/irradiated autologous PBMCs. Two colon cancer cells, SW480 and HT-29 cells were used to analyze the expression of NKG2D ligands and EGFR by radiation. The surface expression ratio was analyzed using flow cytometry. The cytotoxicity of radiation plus NK cell-based targeted therapy against colorectal cancer cell lines was analyzed using flow cytometry.
Results
Activated and irradiated PBMCs significantly increased the expression of various activating ligands that stimulate NK cells. This method finally obtained more than 10,000-fold high-purity activated NK cells, with negligible T-cell contamination. To confirm the antitumor activity of NK cells expanded by this method, we treated expanded NK cells with radiotherapy or a combination of radiotherapy and cetuximab using human colon cancer cells. Expanded NK cells were effective at targeting human colon cancer cells, especially when combined with radiotherapy and cetuximab.
Conclusions
We developed a novel method to robustly expand NK cells using activated and irradiated peripheral blood mononuclear cells (PBMCs) without cancer cells or virus-derived feeder cells. In addition, the combined radiotherapy and antibody-based immunotherapy with expanded NK cells may be an effective way to enhance the treatment efficiency of colon cancer.