bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting estrogen-regulated system xc− promotes ferroptosis and endocrine sensitivity of ER+ breast cancer
Authors: Cao Jiawei , Zhou Tong , Wu Tao , Lin Rixu , Huang Ju , Shi Dejin , Yu Jiawei , Ren Yinrui , Qian Changrui , He Licai , Wu Guang , Dong Zhixiong , Yuan Shaofei , Gu Haihua 
Published: January 2025

Abstract
Estrogen receptor positive (ER+) breast cancer accounts for approximately 70% of cases. Endocrine therapies targeting estrogen are the first line therapies for ER+ breast cancer. However, resistance to these therapies occurs in about half of patients, leading to decreased survival rates. Inducing ferroptosis is a promising therapeutic strategy for cancer treatment for refractory and malignant cancers including triple-negative breast cancer. Nevertheless, ER+ breast cancer is relatively resistant to ferroptosis inducers. Here, we uncovered that ERα suppressed ferroptosis in ER+ breast cancer. Silencing ERα triggered ferroptosis, which was attenuated by ferroptosis inhibitor Ferrostatin-1, and was enhanced by ferroptosis inducer Erastin. Mechanistically, ERα transcriptionally upregulated the expression of SLC7A11 and SLC3A2, two subunits of the system xc
−, which is one key inhibitory regulator of ferroptosis. Overexpression of the exogenous SLC7A11 and SLC3A2 was able to mitigate ferroptosis induced by ERα inhibition. Moreover, SLC7A11 and SLC3A2 levels were elevated in endocrine-resistant breast cancer cells and tumors. Importantly, the system xc
− inhibitor Sorafenib or Imidazole ketone erastin effectively inhibited the growth of tamoxifen-resistant breast cells in vitro and in vivo. In conclusion, our data reveal that targeting estrogen-regulated SLC7A11 and SLC3A2 enhances ferroptosis in ER+ breast cancer, offering a novel therapeutic option for patients with ER+ breast cancer, particularly those with endocrine resistance.
S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis
Authors: Lian Panpan , Li Li , Lu Renwei , Zhang Bin , Wazir Junaid , Gu Chaode , Ma Bojie , Pu Wenyuan , Cao Wangsen , Huang Zhiqiang , Su Zhonglan , Wang Hongwei 
Published: January 2025

Abstract
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and persistent inflammation. Although persistent activation of signal transducer and activator of transcription 3 (STAT3) is implicated in its pathogenesis, the mechanisms underlying the sustained STAT3 activation remain poorly understood. Here, we identify sphingosine-1-phosphate receptor 3 (S1PR3) as a critical regulator of STAT3 activation and psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustains keratinocyte hyperproliferation and chronic inflammation. S1PR3 expression is markedly elevated in psoriatic lesions and correlates with disease severity. Using genetic and pharmacological approaches, we reveal a novel S1PR3–Src–STAT3 signaling axis that drives both early and prolonged STAT3 activation in keratinocytes. Mechanistically, S1PR3 operates through Gαi/PKA-mediated Src activation, enhancing STAT3 phosphorylation and subsequent transcriptional activity. Importantly, we reveal a previously unrecognized positive feedback loop wherein activated STAT3 directly upregulates S1PR3 expression, perpetuating inflammation and hyperproliferation. Genetic deletion of S1pr3 in mice or pharmacological inhibition of S1PR3 significantly attenuates psoriasis-like skin inflammation, decreasing epidermal hyperplasia, dermal angiogenesis, and inflammatory mediator production. These findings provide new insights into the molecular mechanisms underlying psoriasis and identify S1PR3 as a promising therapeutic target. Our study suggests that disrupting the S1PR3–STAT3 feedback loop may offer a novel strategy for treating psoriasis and potentially other chronic inflammatory diseases driven by persistent STAT3 activation.
Unveiling pelagic-benthic coupling associated with the biological carbon pump in the Fram Strait (Arctic Ocean)
Authors: Ramondenc Simon , Eveillard Damien , Metfies Katja , Iversen Morten H. , Nöthig Eva-Maria , Piepenburg Dieter , Hasemann Christiane , Soltwedel Thomas 
Published: January 2025

Abstract
Settling aggregates transport organic matter from the ocean surface to the deep sea and seafloor. Though plankton communities impact carbon export, how specific organisms and their interactions affect export efficiency is unknown. Looking at 15 years of eDNA sequences (18S-V4) from settling and sedimented organic matter in the Fram Strait, here we observe that most phylogenetic groups were transferred from pelagic to benthic ecosystems. Chaetoceros socialis, sea-ice diatoms, Radiolaria, and Chaetognatha are critical components of vertical carbon flux to 200 m depth. In contrast, the diatom C. socialis alone is essential for the amount of organic carbon reaching the seafloor. Spatiotemporal changes in community composition show decreasing diatom abundance during warm anomalies, which would reduce the efficiency of a diatom-driven biological carbon pump. Interestingly, several parasites are also tightly associated with carbon flux and show a strong vertical connectivity, suggesting a potential role in sedimentation processes involving their hosts, especially through interactions with resting spores, which could have implications for pelagic-benthic coupling and overall ecosystem functioning.
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome
Authors: Goold Hugh D. , Kroukamp Heinrich , Erpf Paige E. , Zhao Yu , Kelso Philip , Calame Julie , Timmins John J. B. , Wightman Elizabeth L. I. , Peng Kai , Carpenter Alexander C. , Llorente Briardo , Hawthorne Carmen , Clay Samuel , van Wyk Niël , Daniel Elizabeth L. , Harrison Fergus , Meier Felix , Willows Robert D. , Cai Yizhi , Walker Roy S. K. , Xu Xin , Espinosa Monica I. , Stracquadanio Giovanni , Bader Joel S. , Mitchell Leslie A. , Boeke Jef D. , Williams Thomas C. , Paulsen Ian T. , Pretorius Isak S. 
Published: January 2025

Abstract
The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In this paper we describe assembly and debugging of the 902,994-bp synthetic Saccharomyces cerevisiae chromosome synXVI of the Sc2.0 project. Application of the CRISPR D-BUGS protocol identified defective loci, which were modified to improve sporulation and recover wild-type like growth when grown on glycerol as a sole carbon source when grown at 37˚C. LoxPsym sites inserted downstream of dubious open reading frames impacted the 5’ UTR of genes required for optimal growth and were identified as a systematic cause of defective growth. Based on lessons learned from analysis of Sc2.0 defects and synXVI, an in-silico redesign of the synXVI chromosome was performed, which can be used as a blueprint for future synthetic yeast genome designs. The in-silico redesign of synXVI includes reduced PCR tag frequency, modified chunk and megachunk termini, and adjustments to allocation of loxPsym sites and TAA stop codons to dubious ORFs. This redesign provides a roadmap into applications of Sc2.0 strategies in non-yeast organisms.
Allylic C–H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system
Authors: Wang Le , She Yuan , Xiao Jie , Li Zi-Hao , Zhang Shen-Yuan , Lian Peng-Fei , Ding Tong-Mei , Zhang Shu-Yu 
Published: January 2025

Abstract
Allylic ethers and alcohols are essential structural motifs commonly present in natural products and pharmaceuticals. Direct allylic C–H oxygenation of internal alkenes is one of the most direct methods, bypassing the necessity for an allylic leaving group that is needed in the traditional Tsuji–Trost reaction. Herein, we develop an efficient and practical method for synthesizing (E)-allyl ethers from readily available internal alkenes and alcohols or phenols via selective allylic C–H oxidation. Key advances include the use of a Cu/Azodiformate catalyst system to facilitate remote allylic C–H activation and the achievement of excellent chemoselectivity through a dynamic ligand exchange strategy using a bis(sulfonamide) ligand. This method features a broad substrate scope and functional group tolerance, successfully applied to the synthesis of various challenging medium-sized cyclic ethers (7-10 members) and large-ring lactones (14-20 members), with high regioselectivity and stereoselectivity.
Performance and emissions of diesel engine combustion lubricated with Jatropha bio-lubricant and MWCNT additive
Authors: Uppar Rajendra , Dinesha P. , Kumar Shiva 
Published: January 2025

Abstract
Vegetable oil-based lubricants, modified through transesterification and epoxidation, present a sustainable alternative to mineral lubricants for transport and industrial use. This study evaluates epoxidized jatropha oil (EJA) enhanced with multi-walled carbon nanotubes (MWCNT) as a bio-lubricant for compression ignition engines. MWCNT, dispersed in EJA using an ultrasonic probe sonicator with Triton X-100 as a surfactant, was tested at nanoparticle concentrations from 0.5 to 2 wt%. Engine performance and emission characteristics were assessed using SAE 20W40, EJA, and EJA-MWCNT in a four-stroke diesel engine. Results showed that EJA with 2 wt% MWCNT reduced friction power by 39.13% compared to SAE 20W40 and decreased brake specific energy consumption by 6.11%, while lowering emissions of hydrocarbons, carbon monoxide, and smoke. These findings highlight EJA-MWCNT as a promising lubricant for diesel engines, enhancing efficiency and reducing pollutants, making it a viable eco-friendly substitute for diminishing petroleum resources.
Low interface state density and large capacitive memory window using RF sputtered NiO nanoparticles decorated MgZnO thin film
Authors: Kumar Mritunjay , Dhar Jay Chandra 
Published: January 2025

Abstract
NiO nanoparticles (NPs) synthesized using glancing angle deposition (GLAD) technique over MgZnO thin film was used to design a novel memory device. The NiO NPs with average diameter ~ 9.5 nm was uniformly distributed over the MgZnO thin film surface. The MgZnO thin film/NiO NPs memory device when measured for the C-V hysteresis characteristics at varying sweep voltage demonstrated a charge trapping and de-trapping mechanism. Moreover, the device exhibited low interface states density (Dit) (1.45 × 1010 eV− 1 cm− 2) at 1 MHz and large capacitive memory of  ~ 6 V at ± 7 V. The large memory window was attributed to the better interface quality between MgZnO thin film and NiO NPs. Additionally, the device also exhibited good endurance over 1000 programme/erase cycles and longer time charge retention up to 2 × 104 s. The improved performance of device and more charge accumulation capacity was primarily due to the large effective area and quantum confinement effect owing to NiO NPs. Further, on performing a resistive switching analysis, the device could show a good on-off ratio (RHRS/RLRS) of 1.24 × 102. Therefore, the proposed device structure can be a good option for future memory applications.
Increased arterial stiffness is associated with poorer social cognition in older age
Authors: Grainger Sarah A. , Bailey Tom G. , Vear Natalie K. , Mead Jessica K. , Bourdaniotis Xanthia E. , Coombes Jeff S. , Taylor Jenna L. 
Published: January 2025

Abstract
It is now well established that vascular aging is a significant predictor of cognitive decline in older age. But what remains less clear is the role that vascular health plays in social cognitive aging. Therefore, we aimed to provide the first test of the relationship between arterial stiffness and theory of mind (ToM) in late adulthood. In a sample of 50 healthy older adults (Age: M = 70.08, SD = 3.93), we measured arterial stiffness via carotid-femoral pulse wave velocity and social cognition using two well validated measures of ToM (RMET, TASIT). The results revealed that arterial stiffness was a significant predictor of ToM performance when indexed via the RMET and the TASIT, accounting for 11% and 9% of unique variance in scores, respectively. These findings add to the broader literature showing that arterial stiffness is a key predictor of cognitive aging and show that this relationship extends to the domain of social cognition.
Structure and quantification of Ce3+/Ce4+ and stability analysis of basaltic glasses for the immobilization of simulated tetravalent amines
Authors: Tong Qin , Liu Song , Liang Jun , Zhang Qi , Liao Meiying 
Published: January 2025

Abstract
Basaltic glass was prepared via the solid-state melt method, using Ce4+ to simulate tetravalent actinides. The structure, thermal stability and leaching characteristics of basaltic glass with different contents of CeO2 were investigated. The XRD/SEM-EDX/Raman results showed that the simulated waste loading of CeO2 in basaltic glass reached ~ 18 wt%, and CeO2 crystals precipitated when the CeO2 content reached 20 wt%. XPS analysis revealed that approximately half of the Ce4+ ions in the basaltic glass doped with CeO2 were reduced to Ce3+ ions. The DSC results showed that the thermal stability increased with increasing CeO2 content. The ASTM product consistency test (PCT) results indicated that all the samples had good leaching resistance. Among them, the standard mass loss of Ce was the greatest after 28 days: The NL
Ce was 2 orders of magnitude lower than those of the other elements.
Cesarean delivery on child health and development in Japanese nationwide birth cohort
Authors: Matsumoto Naomi , Mitsui Takashi , Tamai Kei , Hirota Tomoya , Masuyama Hisashi , Yorifuji Takashi 
Published: January 2025

Abstract
The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997–1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups.
Advancing transnational assessments of biodiversity drivers in European agriculture with an updated hierarchical crop and agriculture taxonomy (HCAT)
Authors: Schneider Maja , Gackstetter David , Prexl Jonathan , Meyer Sebastian T. , Körner Marco 
Published: January 2025

Abstract
By homogenizing landscapes and reducing natural habitats, modern agriculture plays a significant role in reducing natural species populations worldwide. Despite advances in research, quantifying the impacts of cropping systems on biodiversity remains challenging due to the lack of comprehensive agricultural data. Within the European Union’s (EU) common agricultural policy (CAP), farmers are required to declare cropping arrangements to receive subsidies. The resulting data is collected by each EU member state individually, leading to inconsistent crop taxonomies across the EU, which hinders transnational analyses of agriculture and related impacts. To overcome this barrier, we developed a hierarchical crop and agriculture taxonomy (HCAT), which harmonizes administrative and agricultural data from 16 EU member states. With the release of an upgraded second version of HCAT, we demonstrate, using the example of biodiversity drivers, how a harmonized CAP data set can aid in identifying indicators related to environmental impacts in agricultural landscapes at international scales.
Informational ecosystems partially explain differences in socioenvironmental conceptual associations between U.S. American racial groups
Authors: Vargas Roberto , Verstynen Timothy 
Published: January 2025

Abstract
Social groups represent a collective identity defined by a distinct consensus of concepts (e.g., ideas, values, and goals) whose structural relationship varies between groups. Here we set out to measure how a set of inter-concept semantic associations, comprising what we refer to as a concept graph, covaries between established social groups, based on racial identity, and how this effect is mediated by information ecosystems, contextualized as news sources. Group differences among racial identity (278 Black and 294 white Americans) and informational ecosystems (Left- and Right- leaning news sources) are present in subjective judgments of how the meaning of concepts such as healthcare, police, and voting relate to each other. These racial group differences in concept graphs were partially mediated by the bias of news sources that individuals get their information from. This supports the idea of groups being defined by common conceptual semantic relationships that partially arise from shared information ecosystems.
A learning‐based energy management strategy for hybrid energy storage systems with compressed air and solid oxide fuel cells
Authors: Guan Yundie , Zhang Xiangyu , Liang Zheming , Chen Tao 
Published: January 2025

AbstractThe intermittency and volatility of renewable energy have been major challenges in modern power systems. This paper proposes a self‐adaptive energy management strategy based on deep reinforcement learning (DRL) to integrate renewable energy sources into a system comprising compressed air energy storage, battery energy storage systems, and solid oxide fuel cells. However, the basic deep deterministic policy gradient algorithm lacks sensitivity to environmental changes, particularly when there is a mismatch in module capacity within the system. This limitation may affect the proper selection of the charging and discharging actions for the hybrid energy storage system. Thus, some modifications are dedicated to the careful replay buffer design in the basic algorithm, improving the ability to identify subtle changes in the reward function. The proposed method is also compared with other DRL methods to validate the feasibility and effectiveness. The simulation results demonstrate the compatibility of the improved algorithm with the proposed energy management strategy and better performance in terms of economic benefits.
Postvirale Zustände und Post-Covid-19-Erkrankungen – zwei erfolgreich
mit Homöopathie behandelte Fallbeispiele aus der Hausarztpraxis
Authors: Etter Gisela 
Published: January 2025

ZusammenfassungAm 30. August 2023 wurde in der Schweiz eine Empfehlung für Ärztinnen und Ärzte
in der Grundversorgung zum Vorgehen bei einer Post-Covid-19-Erkrankung
publiziert. Da sich nach wie vor keine ursächliche Behandlung etabliert hat,
empfiehlt man wie bei anderen postviralen Zuständen einen symptombasierten
Ansatz. Im Artikel werden zwei erfolgreich mit Homöopathie behandelte Patienten
beschrieben: ein 14-jähriger Junge mit Leistungsminderung, Kopfschmerzen und
rezidivierenden Halsinfekten nach einer Infektion mit SARS-CoV-2 und eine ca.
50-jährige Frau mit Ageusie und Anosmie nach einer sehr wahrscheinlichen
Infektion mit SARS-CoV-2.
Influence of the external N and P inputs on nutrients in the coastal area of Xiamen, China
Authors: Dai Siying , Hu Jiehua , Wang Shanshan , Huang Siming , Tian Rong , Zhao Shuhui , Luo Yang , Zhang Xiaoke , Sun Xia , Yan Jinpei 
Published: January 2025

Environmental context External nutrients giving rise to critical ecological issues of the coastal seawater. We investigated the nearshore nutrient concentrations and their sources in Xiamen Bay during 2013–18. Our results could provide theoretical support for controlling nearshore nutrient pollution. Rationale External nutrients greatly increase the critical ecological risks of the coastal seawater. Therefore, it is important to understand the sources and variation characteristics of nitrogen (N) and phosphorus (P) in the coastal area. Methodology The dissolved inorganic nitrogen (DIN) and phosphate (PO4–P) in coastal Xiamen were monitored from 2013 to 2018. The input of nitrogen from runoff in the coastal Xiamen was calculated from the runoff flow amount collected by Xiamen Marine and Fisheries Bureau. Atmospheric dry deposition of DIN was simulated using Williams model to analyse the potential sources of nutrients in the coastal Xiamen. Results High DIN and PO4–P levels occurred in the inner bay and decreased dramatically outside Xiamen Bay. The lowest values of DIN and PO4–P were observed in summer, which is consistent with the temporal variation in nutrient inputs from the surface runoff and atmospheric deposition. The nutrient input of Jiulong River is the main source of eutrophication for Xiamen Bay, providing more than 4 × 104 tonnes (Mg) of N input per year. The atmospheric N dry deposition provided more than 2.2 × 103 Mg of DIN input per year, which accounts for ~3.4–6.3% of the Jiulong River DIN input in the coastal Xiamen. Discussion The ratio of atmospheric nitrogen deposition to nitrogen enrichment from Jiulong River varied from 0.21 to 0.40, indicating that atmospheric nitrogen deposition was an important contributor to the coastal nutrient in Xiamen. This study provides an insight into the major sources of N and P and highlights the importance of atmospheric nitrogen deposition to the DIN in the coastal city Xiamen.
The magneto-mechanical coupling of multiphase magnetorheological elastomers
Authors: Barron III Edward J , Williams Ella T , Lazarus Nathan , Bartlett Michael D 
Published: January 2025

Abstract
Magnetorheological elastomers (MREs) are soft magnetic composites that achieve tunable changes in stiffness and damping in the presence of a magnetic field. Rigid particle composite (RC) MREs have been studied for decades for their potential applications to automotive dampers and robotic systems. Recently, magnetic fluid composite (FC) MREs have been developed which utilize magnetic fluids as inclusions to elastomers. An investigation into how inclusion phase affects magneto-mechanical performance may greatly improve MRE design capabilities. Here we experimentally evaluate the impact of solid and liquid magnetic inclusions on MRE properties, construct a simple model that captures the performance of diverse MRE material architectures, and demonstrate the use of the model to create material design maps relating the material structure, zero-field properties, and applied field to the elastic modulus and specific loss. The magneto-mechanical response is evaluated for three material architectures: RC, FC, and hybrid composite MREs that use solid particles, magnetic fluids, and a combination of the two as inclusions respectively. The model is developed through magnetic and mechanical energy principles, which suggests that the phase of the magnetic inclusions impacts the change in energy density during deformation. We show that the magneto-mechanical coupling factor is dependent on the zero-field properties of the composites, which allows for the development of material design maps to inform the fabrication of MREs based on desired properties.