bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Pathological complete response to perioperative treatment of radiotherapy combined with angiogenesis inhibitor in a patient with pleomorphic liposarcoma
Authors: Zhang Chenlu , Liu Wenshuai , Wang Binliang , Zhu Na , Guo Xi , Wang Zhiming , Zhuang Rongyuan , You Yang , Zhang Yong , Tong Hanxing , Lu Weiqi , Zhou Yuhong 
Published: January 2023

BackgroundLiposarcomas (LPS) are mesenchymal malignancies with four principal subtypes presenting distinct molecular and clinical features. Pleomorphic liposarcoma (PLPS) is one of the rarest and most aggressive subtypes of LPS. Surgical resection is currently a preferred curative approach for localized PLPS. However, the prognosis of unresectable PLPS is extremely poor, and there is no standard treatment.Case presentationA 59-year-old Chinese woman was diagnosed with unresectable PLPS. The case was discussed and managed by specialists from a multidisciplinary team at Fudan Zhongshan Hospital. Preoperative radiotherapy (RT) of intensity-modulated radiation therapy (IMRT) at 50 Gy/25 Fx concurrently with the angiogenesis inhibitor anlotinib (8 mg, days 1–14, every 3 weeks) was prescribed to the patient. The dosage of anlotinib was increased to 10 mg after RT. After 6 months of treatment, the tumor had significantly shrunk and was successfully resected. Examination of the surgical specimens showed a pathological complete response (pCR). Until the latest follow-up (April 2022), no recurrence was observed, and disease-free survival has exceeded 14 months.ConclusionThis case sheds light on the probability that perioperative RT combined with an angiogenesis inhibitor can be effectively used in PLPS, which is resistant to chemotherapy and usually considered to have a poor prognosis. Further studies with randomized controlled clinical trials will improve our knowledge of this preoperative treatment strategy.
Comparative study of surface integral methods in aeroacoustic prediction
Authors: Xu Chen , Wang Shihao , Yang Dangguo , Zhang Rongping , Jiang Shujie , Mao Yijun 
Published: January 2023

Introduction: Surface integral methods based on the acoustic analogy and Kirchhoff formulation are widely employed in computational aeroacoustics. The computational accuracy is usually highly dependent on the selections of the acoustic prediction method and of the integral surfaces.Methods: This paper analyzes the pros and cons of each aeroacoustic prediction method and studies numerically sound generated from flow past a circular cylinder by employing different surface integral methods. The acoustic analogy based on the impermeable solid surfaces either ignores the quadrupole contribution or needs high computational cost to calculate the quadrupole contribution, and the acoustic analogy based on the permeable integral surfaces usually suffers from the spurious source issue.Results: Both the pressure-based or density-based Kirchhoff formulations can be used in aeroacoustic prediction, however, the numerical results indicate that the pressure-based Kirchhoff formulation also suffers from the issue of the spurious sound because the pressure fluctuations at the permeable integral surfaces are contaminated by hydrodynamic component.Discussion: It seems that only the density-based Kirchhoff formulation does not suffer from the issue of the spurious sound, but this formulation requires the acoustic sources should be extracted from compressible flow simulations.
Effects of different simulated submarine escape depths by free ascent in animal models
Authors: Bao Xiao Chen , Wang Nan , Xu Ji , Ma Jun , Fang Yi-Qun 
Published: January 2023

Objective: If a damaged submarine cannot be rescued in time, it is necessary to carry out a submarine escape by free ascent. Decompression illness is the greatest threat to the safety of submariners. The maximum depth at which a safe escape can be carried out is unknown. This study intends to explore the maximum safe escape depth by observing the effects of simulated submarine escape at different depths on animal models.Methods: We evaluated pulmonary function indexes, blood gas values, blood cell counts, the myocardial enzyme spectrum, coagulation parameters, and proinflammatory cytokine levels in rats, electrocardiographic activity in rabbits after simulated 150-m, 200-m, 220-m, and 250-m submarine escape by free ascent.Results: An escape depth of 150 m did not cause significant changes in the indicators. An escape depth of &gt;200 m led to pulmonary ventilation and gas diffusion dysfunction, hypoxemia, myocardial ischemia, and activation of the fibrinolytic and inflammatory systems. The magnitudes of the changes in the indicators were proportional to escape depth.Conclusion: An escape depth of 150 m in animal models is safe, whereas escape at &gt; 200 m can be harmful.
Weighted gene co-expression network analysis identifies genes related to HG Type 0 resistance and verification of hub gene GmHg1
Authors: Jiang Haipeng , Zhou Changjun , Ma Jinglin , Qu Shuo , Liu Fang , Sun Haowen , Zhao Xue , Han Yingpeng 
Published: January 2023

IntroductionThe soybean cyst nematode (SCN) is a major disease in soybean production thatseriously affects soybean yield. At present, there are no studies on weighted geneco-expression network analysis (WGCNA) related to SCN resistance.MethodsHere, transcriptome data from 36 soybean roots under SCN HG Type 0 (race 3) stresswere used in WGCNA to identify significant modules.Results and DiscussionA total of 10,000 differentially expressed genes and 21 modules were identified, of which the module most related to SCN was turquoise. In addition, the hub gene GmHg1 with high connectivity was selected, and its function was verified. GmHg1 encodes serine/threonine protein kinase (PK), and the expression of GmHg1 in SCN-resistant cultivars (‘Dongnong L-204’) and SCN-susceptible cultivars (‘Heinong 37’) increased significantly after HG Type 0 stress. Soybean plants transformed with GmHg1-OX had significantly increased SCN resistance. In contrast, the GmHg1-RNAi transgenic soybean plants significantly reduced SCN resistance. In transgenic materials, the expression patterns of 11 genes with the same expression trend as the GmHg1 gene in the ‘turquoise module’ were analyzed. Analysis showed that 11genes were co-expressed with GmHg1, which may be involved in the process of soybean resistance to SCN. Our work provides a new direction for studying the Molecular mechanism of soybean resistance to SCN.
Spatiotemporal dynamics of net primary productivity and its influencing factors in the middle reaches of the Yellow River from 2000 to 2020
Authors: Xuan Wenxi , Rao Liangyi 
Published: January 2023

IntroductionNet primary productivity (NPP) is an important indicator used to characterize the productivity of terrestrial ecosystems. The spatial distribution and dynamic change in NPP are closely related to regional climate, vegetation growth and human activities. Studying the spatiotemporal dynamics of NPP and its influencing factors plays a vital role in understanding ecosystem carbon sink capacity.MethodsBased on MODIS-NPP data, meteorological data, and land use data from 2000 to 2020, we analyzed the spatiotemporal variation characteristics and influencing factors of NPP in the middle reaches of the Yellow River (MRYR) by using unary linear regression analysis, third-order partial correlation analysis, and Sen+Mann-Kendall trend analysis.ResultsThe results showed that the annual average NPP of the MRYR was 319.24 gCm-2a-1 with a spatially decreasing trend from the southern part to the northern part. From 2000 to 2020, the annual average NPP experienced a fluctuating upward trend at a rate of 2.83 gCm-2a-1, and the area with a significant upward trend accounted for 87.68%. The NPP of different land use types differed greatly, in which forest had the greatest increase in NPP. Temperature had a negative correlation with NPP in most parts of the MRYR. Water vapor pressure promoted the accumulation of NPP in the northwestern MRYR. The areas with a positive correlation between NPP and water vapor pressure accounted for 87.6%, and 20.43% of the MRYR area passed the significance test of P&lt; 0.05.ConclusionThe results of the study highlight the impact of climate factors and land-use changes on NPP and provide theoretical guidance for high-quality sustainable development in the MRYR.
How do online users perceive health risks during public health emergencies? Empirical evidence from China
Authors: Huang Shijing , Zhou Cheng , Yuan Qinjian , Chen Guohua , Shen Hongzhou 
Published: January 2023

BackgroundThe global COVID-19 pandemic has posed a major threat to human life and health, and new media technologies have intensified the spread of risk perception.PurposeThis study aimed to explore the impact of risk information ground on online users’ perceived health risks, and further explore the mediating role of psychological distance and the moderating role of self-efficacy.MethodsA total of 25 Internet users from different provinces in China were interviewed in-depth, NVIVO.11 was used to qualitatively analyze the interview text data and construct a theoretical model. A total of 492 interviewees were recruited in order to complete a scenario questionnaire, SPSS-27 was used to perform orthogonal experiments, generate eight combinatorial scenarios, analyze demographic data, and clean and prepare data for testing hypotheses. SmartPLS 3.0 was used to test the conceptual model using the structural equation model (SEM) of the partial least squares (PLS).ResultsThe analysis of the SEM model shows that all planned hypotheses (Information fluency → Information diagnosability, Information extensibility → Information diagnosability, Information diagnosability → Psychological distance, Platform interactivity → Scenario embeddedness, Network connectivity → Scenario embeddedness, Scenario embeddedness → Psychological distance, Psychological distance → Risk perception, Psychological distance → Self-efficacy → Risk perception, Information fluency → Information diagnosability → Psychological distance → Risk perception, Information extensibility → Information diagnosability → Psychological distance → Risk perception, Platform interactivity → Scenario embeddedness → Psychological distance → Risk perception, Network connectivity → Scenario embeddedness → Psychological distance → Risk perception) are confirmed.ConclusionThis study found that the information ground factors significantly affect online users’ perceptions of health risks, psychological distance mediates the effect of information ground factors on risk perception, and self-efficacy negatively moderates the effect of psychological distance on risk perception.
A systematic review and meta-analysis of interventions to decrease cyberbullying perpetration and victimization: An in-depth analysis within the Asia Pacific region
Authors: Kamaruddin Ida Khairina , Ma’rof Aini Marina , Mohd Nazan Ahmad Iqmer Nashriq , Ab Jalil Habibah 
Published: January 2023

BackgroundCyberbullying perpetration and victimization are prevalent issues in adolescent development and are a rising public health concern. Numerous interventions have been developed and implemented to decrease cyberbullying perpetration and victimization. Through an updated systematic review and meta-analysis, this study aimed to tackle a significant gap in the cyberbullying literature by addressing the need to empirically determine the effectiveness of programs with non-school-aged samples with a specific focus on studies conducted within the Asia-Pacific region.MethodsA systematic literature review was conducted to identify intervention research to reduce cyberbullying perpetration and victimization published from January 1995 to February 2022. Ten electronic databases—Cambridge Journal Online, EBSCOHOST, ERIC, IEEE XPLORE, Oxford Journal Online, ProQuest Dissertations and Theses, PubMed (Medline), Science Direct, Scopus, Springerlink—and a subsequent manual search were conducted. Detailed information was extracted, including the summary data that could be used to estimate effect sizes. The studies’ methodological quality was assessed using the Effective Public Health Practice Project (EPHPP) quality assessment tool.FindingsEleven studies were included in the review of the 2,540 studies identified through databases, and 114 additional records were discovered through citation searching. Only four studies were included in the meta-analysis, exploring game-based, skill-building, school-based, and whole-school interventions. The first meta-analysis pooled estimates from these four studies that assessed cyberbullying perpetration frequency using continuous data post-intervention. These studies reported data from 3,273 participants (intervention n = 1,802 and control n = 1,471). A small but not statistically significant improvement favoring the intervention group from pre- to post-intervention was shown by the pooled effect size, −0.04 (95% CI [−0.10,0.03], Z = 1.11, P = 0.27). The second meta-analysis included two qualified studies investigating cyberbullying victimization frequency using continuous data at post-intervention among 2,954 participants (intervention n = 1,623 and control n = 1,331). A very small but non-significant effect favoring the intervention group was discovered.ConclusionThis research primarily highlights that the endeavor for cyberbullying intervention is still developing in the Asia-Pacific region, currently involving a limited set of stakeholders, settings, and delivery modes. Overall, meta-analyses of cyberbullying interventions conducted in the Asia Pacific found no significant effects in reducing cyberbullying perpetration and victimization.
Development and validation of questionnaire-based machine learning models for predicting all-cause mortality in a representative population of China
Authors: Li Ziyi , Yang Na , He Liyun , Wang Jialu , Ping Fan , Li Wei , Xu Lingling , Zhang Huabing , Li Yuxiu 
Published: January 2023

BackgroundConsidering that the previously developed mortality prediction models have limited applications to the Chinese population, a questionnaire-based prediction model is of great importance for its accuracy and convenience in clinical practice.MethodsTwo national cohort, namely, the China Health and Nutrition Survey (8,355 individual older than 18) and the China Health and Retirement Longitudinal Study (12,711 individuals older than 45) were used for model development and validation. One hundred and fifty-nine variables were compiled to generate predictions. The Cox regression model and six machine learning (ML) models were used to predict all-cause mortality. Finally, a simple questionnaire-based ML prediction model was developed using the best algorithm and validated.ResultsIn the internal validation set, all the ML models performed better than the traditional Cox model in predicting 6-year mortality and the random survival forest (RSF) model performed best. The questionnaire-based ML model, which only included 20 variables, achieved a C-index of 0.86 (95%CI: 0.80–0.92). On external validation, the simple questionnaire-based model achieved a C-index of 0.82 (95%CI: 0.77–0.87), 0.77 (95%CI: 0.75–0.79), and 0.79 (95%CI: 0.77–0.81), respectively, in predicting 2-, 9-, and 11-year mortality.ConclusionsIn this prospective population-based study, a model based on the RSF analysis performed best among all models. Furthermore, there was no significant difference between the prediction performance of the questionnaire-based ML model, which only included 20 variables, and that of the model with all variables (including laboratory variables). The simple questionnaire-based ML prediction model, which needs to be further explored, is of great importance for its accuracy and suitability to the Chinese general population.
Communicating risk during early phases of COVID-19: Comparing governing structures for emergency risk communication across four contexts
Authors: Geurts Brogan , Weishaar Heide , Mari Saez Almudena , Cristea Florin , Rocha Carlos , Aminu Kafayat , Tan Melisa Mei Jin , Salim Camara Bienvenu , Barry Lansana , Thea Paul , Boucsein Johannes , Bahr Thurid , Al-Awlaqi Sameh , Pozo-Martin Francisco , Boklage Evgeniya , Delamou Alexandre , Jegede Ayodele Samuel , Legido-Quigley Helena , El Bcheraoui Charbel 
Published: January 2023

BackgroundEmergency risk communication (ERC) is key to achieving compliance with public health measures during pandemics. Yet, the factors that facilitated ERC during COVID-19 have not been analyzed. We compare ERC in the early stages of the pandemic across four socio-economic settings to identify how risk communication can be improved in public health emergencies (PHE).MethodsTo map and assess the content, process, actors, and context of ERC in Germany, Guinea, Nigeria, and Singapore, we performed a qualitative document review, and thematically analyzed semi-structured key informant interviews with 155 stakeholders involved in ERC at national and sub-national levels. We applied Walt and Gilson's health policy triangle as a framework to structure the results.ResultsWe identified distinct ERC strategies in each of the four countries. Various actors, including governmental leads, experts, and organizations with close contact to the public, collaborated closely to implement ERC strategies. Early integration of ERC into preparedness and response plans, lessons from previous experiences, existing structures and networks, and clear leadership were identified as crucial for ensuring message clarity, consistency, relevance, and an efficient use of resources. Areas of improvement primarily included two-way communication, community engagement, and monitoring and evaluation. Countries with recurrent experiences of pandemics appeared to be more prepared and equipped to implement ERC strategies.ConclusionWe found that considerable potential exists for countries to improve communication during public health emergencies, particularly in the areas of bilateral communication and community engagement as well as monitoring and evaluation. Building adaptive structures and maintaining long-term relationships with at-risk communities reportedly facilitated suitable communication. The findings suggest considerable potential and transferable learning opportunities exist between countries in the global north and countries in the global south with experience of managing outbreaks.
Home or hospital as the place of end-of-life care and death: A survey among Chinese residents of Macao
Authors: Tam Kuai In , Che Sok Leng , Zhu Mingxia , Leong Sok Man 
Published: January 2023

ObjectivesThe study was the first to explore Chinese residents' preferred place of care at the end of life and preferred place of death in Macao.MethodsA cross-sectional questionnaire survey was conducted online and face-to-face. The questionnaire was designed in Chinese, and both online and face-to-face surveys were conducted in Chinese. The study was conducted in Macao. Macao residents aged 18 years and older were recruited.ResultsA total of 737 responses were valid, 65% were female, aged between 19 and 101 years; 43.4% of respondents preferred to be cared for at home in the last 6 months; however, less than one-fifth preferred to die at home. One-third of respondents chose to die in the hospice, and over a quarter of them preferred to die in hospitals. Compared with people aged between 18 and 39 years, people aged between 40 and 64 years did not want to be cared for at home in the last 6 months, and they did not want to die at home either.ConclusionThe results of the study suggested that there is a need for palliative home care in Macao, and the government should consider developing such a service and review current laws and regulations in supporting the service. Education is equally important for healthcare professionals, enabling them to support palliative care development in the community.
Social distancing cut down the prevalence of acute otitis media in children
Authors: Yu Huiqian , Gu Dantong , Yu Fangzhou , Li Qingzhong 
Published: January 2023

ObjectivesTo evaluate the additional, unintended benefits of social distancing in cutting down the prevalence of acute otitis media (AOM) in children, especially during coronavirus disease 2019 (COVID-19) periods.MethodsThe daily outpatient attendance of AOM for childhood (from 6 months to 12 years) was compared in the tertiary hospital in Shanghai during pre-COVID-19 and COVID-19 year.ResultsA total of 24,543 AOM cases were included from 2015 to 2020. When age was taken into account, children in kindergarten (aged 4–6) constitute 66.2% (16,236/24,543) of all case, followed by primary school students (6,441/24,543, 26.2%) and preschoolers &lt;3 years old (1,866/24,543, 7.6%). There was an estimated 63.6% (54.32–70.36%) reduction in the daily outpatient attendance of AOM associated with the introduction of social distancing in 2020 (COVID-19 year). The epidemic trend of AOM in 2015–2019 was characterized by seasonal fluctuations, with highest incidence in December (18.8 ± 0.5%) and lower in February (4.5 ± 0.2%), June (3.7 ± 0.7%) and August (3.5 ± 0.5%). And distribution characteristics of different ages in COVID-19 period broadly in line with that in non-pandemic period.ConclusionSeasonal fluctuation in the prevalence of AOM was observed in pre-COVID-19 period (2015–2019), with a peak in winter and a nadir in summer. The &gt;50% drop of outpatient attendance of AOM in 2020 (COVID-19 year) suggest that social distancing, mask effects and good hand hygiene can significantly reduce the incidence of AOM, which provides a preventive and therapeutic point of view for AOM.
An enterprise structure approach improves index-based crop portfolio decision-making
Authors: Mzyece Agness , Amanor-Boadu Vincent , Ng'ombe John N. 
Published: January 2023

IntroductionWhile crop diversification indices are relatively simple and useful for quantifying the extent of crop diversification, they may not account for the potential differences in the types of crops grown. This study shows the need to complement crop diversification indices with an enterprise structure approach to improve index-based crop portfolio decision making.MethodsThe study uses linear regression models and nationally representative farm survey data from 7,934 farmers in Zambia. The study compares the enterprise approach and the Simpson index of diversification which is commonly used in crop diversification studies.Results and discussionWe find that complementing the enterprise structure approach with the Simpson index of diversification can increase profitability by as high as 77.89% for farmers. The cassava enterprise structure had the most returns for farmers. It had a gross margin of ZMW 3,887 per hectare and was trailed by the maize/groundnuts/cotton/rice enterprise structure with a gross margin of ZMW3,681 per hectare. These results suggest that the use of aggregation crop diversification indices, without an additional enterprise structure analysis, may obscure the necessary insights needed to practically help farmers.