bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study of Anlotinib as a Combination Treatment in Advanced
Nasopharyngeal Carcinoma
Authors: Zhou Rui , Zhou Ping , Yu Yi-Feng , Lin Qin , Wu San-Gang 
Published: August 2023

Aims:
To investigate the short-term objective response and treatment toxicity of anlotinib as a
combination treatment in patients with Recurrent or Metastatic Nasopharyngeal Carcinoma (RM-NPC).

Methods:
Patients with RM-NPC who received anlotinib as a combination treatment between March
2021 and July 2022 were retrospectively analyzed.The efficacy and safety of anlotinib as a combination
treatment were analyzed.

Results:
A total of 17 patients with RM-NPC were included in this study. Of these patients, 2 (11.8%)
had local recurrence, 4 (23.5%) had cervical lymph node recurrence, and 11 (64.9%) had distant failure.
The most common metastatic site was the liver (47.1%), followed by the lung (23.5%) and bone
(23.5%). Anlotinib was given as first-line treatment in 3 patients (17.6%), second lines treatment in 7
patients (41.2%), and third to six-lines treatment in 7 patients (41.2%). All patients received anlotinib
combined with chemotherapy and/or immunotherapy. One patient achieved a complete response (5.9%),
7 patients had a partial response (41.2%), 5 patients had stable disease (29.4%), and 4 patients had progressive
disease (23.5%). The overall disease control rate and the overall response rate were 76.5% and
47.1%, respectively. The median progression-free survival was 8.1 months, and the median overall survival
was not reached. The incidence of grade 3 adverse events was 30%. No unexpected side effects or
treatment-related death were observed.

Conclusion:
Anlotinib, as a combination treatment, has a promising antitumor activity and a manageable
safety profile in patients with RM-NPC. Our results add to the growing evidence that supports the
benefits of combining antiangiogenic drugs in RM-NPC. Randomized controlled clinical trials investigating
the evaluation of anlotinib are warranted.
Development of lipid nanoparticles with nystatin for an antifungal action
Authors: Nascimento Cecilia , Sousa Filipa , Reis Salette , Costa Paulo 
Published: August 2023

Fungal diseases currently affect about a quarter of the population worldwide. Fungi infections caused by Candida albicans have been described as a significant concern to public health. The spectrum of clinical diseases caused by this fungi species range between vulvovaginal candidiasis, oral candidiasis, candidemia and mucositis. The emergence of resistance mechanisms towards antifungal therapy greatly hampers successful management of illness and patient outcome. Nystatin, an antifungal drug, is categorized as a class IV of Biopharmaceutical Classification System, presenting low aqueous solubility and low intestinal permeability. Nowadays, the emerging platform of nanotechnology and lipid nanoparticles, notably solid lipid nanoparticles (SLN), has been subject to growing attention over recent past, owing to the promising properties of vectorization among a substantial variety of pharmaceutical drugs. Due to its hydrophobic proprieties, nystatin was encapsulated in SLN. Thus aiming to understand the relationship between the use of nanosystems and the improvement of the therapeutic effect. The aim of this work was to formulate SLN with nystatin by different methods (high speed homogenization and ultrasonication) with optimization of several parameters and formulation of 2 gels (one of them containing nanoparticles).
Initially, 3 lipids were used: Compritol® 888 ATO, cetyl palmitate and Precirol® ATO 5 and, after the study of several parameters (size, encapsulation efficiency (EE) and polymorphic behaviour of the lipids), Precirol® ATO 5 was chosen as the lipid with the most satisfactory results. The results of the present work showed that the assay method of nystatin was linear, specific and presented repeatability. The average diameter of empty nanoparticles (NPs) and with drug (Precirol-NYS NPs) was, respectively, 306 nm and 260 nm and an EE of 67.8%. Regarding stability, SLN with drug proved to be more stable than SLN without drug. The polymer used for formulation of gels was the polymer commonly known by the trade name Carbopol® 940. The yield of 0.5% Carbopol® gel preparations and 0.5% Carbopol® gel + 10% Precirol-NYS NPs were 87.2% and 91.39%, respectively.
Диффузия и полевая десорбция атомов бария с неоднородной поверхности рения
Authors: Бернацкий Д.П. , Павлов В.Г. 
Published: August 2023

Using field desorption microscopy, it is shown that the nature of desorption by an electric field of adsorbed barium atoms on a quasi-spherical surface of a rhenium single crystal that is inhomogeneous in work function depends on the rate of diffusion of adsorbate atoms over the surface. In the absence of diffusion of barium atoms over the surface (T = 300 K), a pulse character of desorption is observed. At rhenium temperature T = 700 K migration equilibrium is established on the surface, at which the concentration of barium adatoms on the faces of a rhenium single crystal can be different. It has been shown that in this case, a stationary field desorption mode is realized, in which the emission of barium ions comes from faces with higher work function.
Exploring the Impact of Dawn Phenomenon on Glucose-Guided Eating Thresholds in Individuals With Type 2 Diabetes Using Continuous Glucose Monitoring: Observational Study
Authors: Jospe Michelle R , Marano Kari M , Bedoya Arianna R , Behrens Nick L , Cigan Lacey , Villegas Vanessa , Magee Michelle F , Marrero David G , Richardson Kelli M , Liao Yue , Schembre Susan M 
Published: August 2023

Background
Glucose-guided eating (GGE) improves metabolic markers of chronic disease risk, including insulin resistance, in adults without diabetes. GGE is a timed eating paradigm that relies on experiencing feelings of hunger and having a preprandial glucose level below a personalized threshold computed from 2 consecutive morning fasting glucose levels. The dawn phenomenon (DP), which results in elevated morning preprandial glucose levels, could cause typically derived GGE thresholds to be unacceptable or ineffective among people with type 2 diabetes (T2DM).

Objective
The aim of this study is to quantify the incidence and day-to-day variability in the magnitude of DP and examine its effect on morning preprandial glucose levels as a preliminary test of the feasibility of GGE in adults with T2DM.

Methods
Study participants wore a single-blinded Dexcom G6 Pro continuous glucose monitoring (CGM) system for up to 10 days. First and last eating times and any overnight eating were reported using daily surveys over the study duration. DP was expressed as a dichotomous variable at the day level (DP day vs non-DP day) and as a continuous variable reflecting the percent of days DP was experienced on a valid day. A valid day was defined as having no reported overnight eating (between midnight and 6 AM). ∂ Glucose was computed as the difference in nocturnal glucose nadir (between midnight and 6 AM) to morning preprandial glucose levels. ∂ Glucose ≥20 mg/dL constituted a DP day. Using multilevel modeling, we examined the between- and within-person effects of DP on morning preprandial glucose and the effect of evening eating times on DP.

Results
In total, 21 adults (59% female; 13/21, 62%) with non–insulin-treated T2DM wore a CGM for an average of 10.5 (SD 1.1) days. Twenty out of 21 participants (95%) experienced DP for at least 1 day, with an average of 51% of days (SD 27.2; range 0%-100%). The mean ∂ glucose was 23.7 (SD 13.2) mg/dL. People who experience DP more frequently had a morning preprandial glucose level that was 54.1 (95% CI 17.0-83.9; P<.001) mg/dL higher than those who experienced DP less frequently. For within-person effect, morning preprandial glucose levels were 12.1 (95% CI 6.3-17.8; P=.008) mg/dL higher on a DP day than on a non-DP day. The association between ∂ glucose and preprandial glucose levels was 0.50 (95% CI 0.37-0.60; P<.001). There was no effect of the last eating time on DP.

Conclusions
DP was experienced by most study participants regardless of last eating times. The magnitude of the within-person effect of DP on morning preprandial glucose levels was meaningful in the context of GGE. Alternative approaches for determining acceptable and effective GGE thresholds for people with T2DM should be explored and evaluated.
Mental Health Self-Tracking Preferences of Young Adults With Depression and Anxiety Not Engaged in Treatment: Qualitative Analysis
Authors: Beltzer Miranda L , Meyerhoff Jonah , Popowski Sarah A , Mohr David C , Kornfield Rachel 
Published: August 2023

Background
Despite the high prevalence of anxiety and depression among young adults, many do not seek formal treatment. Some may turn to digital mental health tools for support instead, including to self-track moods, behaviors, and other variables related to mental health. Researchers have sought to understand processes and motivations involved in self-tracking, but few have considered the specific needs and preferences of young adults who are not engaged in treatment and who seek to use self-tracking to support mental health.

Objective
This study seeks to assess the types of experiences young adults not engaged in treatment have had with digital self-tracking for mood and other mental health data and to assess how young adults not seeking treatment want to engage in self-tracking to support their mental health.

Methods
We conducted 2 online asynchronous discussion groups with 50 young adults aged 18 years to 25 years who were not engaged in treatment. Participants were recruited after indicating moderate to severe symptoms of depression or anxiety on screening surveys hosted on the website of Mental Health America. Participants who enrolled in the study responded anonymously to discussion prompts on a message board, as well as to each other’s responses, and 3 coders performed a thematic analysis of their responses.

Results
Participants had mixed experiences with self-tracking in the past, including disliking when tracking highlighted unwanted behaviors and discontinuing tracking for a variety of reasons. They had more positive past experiences tracking behaviors and tasks they wanted to increase, using open-ended journaling, and with gamified elements to increase motivation. Participants highlighted several design considerations they wanted self-tracking tools to address, including building self-understanding; organization, reminders, and structure; and simplifying the self-tracking experience. Participants wanted self-tracking to help them identify their feelings and how their feelings related to other variables like sleep, exercise, and events in their lives. Participants also highlighted self-tracking as useful for motivating and supporting basic activities and tasks of daily living during periods of feeling overwhelmed or low mood and providing a sense of accomplishment and stability. Although self-tracking can be burdensome, participants were interested and provided suggestions for simplifying the process.

Conclusions
These young adults not engaged in treatment reported interest in using self-tracking to build self-understanding as a goal in and of itself or as a first step in contemplating and preparing for behavior change or treatment-seeking. Alexithymia, amotivation, and feeling overwhelmed may serve both as barriers to self-tracking and opportunities for self-tracking to help.
Escala de Desregulação Emocional Infantojuvenil (EDEIJ): evidências de validade
Authors: Baptista Makilim Nunes , Noronha Ana Paula Porto , Bonfá-Araujo Bruno 
Published: August 2023

A autorregulação emocional frente a eventos tristes é essencial nas diferentes fases do desenvolvimento humano, principalmente ao tratar-se de crianças e adolescentes, uma vez que diferentes estratégias de autorregulação podem ser fatores protetivos a transtornos mentais como a depressão. Dado a existência da Escala de Autorregulação Emocional-Infantojuvenil (EARE-IJ) para mensurar tais eventos, este artigo tem como objetivo apresentar a versão revisada do instrumento, com o intuito de aprimorá-la, buscar evidências de validade baseadas na estrutura interna e índices de fidedignidade. Responderam ao instrumento 299 crianças e adolescentes, com idades de 10 até 16 anos (M = 12,20; DP = 1,36), de modo que foram testados diferentes modelos de análise fatorial confirmatória, coeficientes de confiabilidade e um modelo de invariância para a variável sexo. Os resultados acumulam evidências favoráveis para o instrumento em sua nova versão, passando a ser conhecida como Escala de Desregulação Emocional Infantojuvenil (EDEIJ). Além de indicarem que o instrumento é capaz de avaliar crianças e adolescentes com diferentes níveis de desregulação emocional, bem como possui invariância configural e métrica. Conclui-se que a ferramenta é eficiente para realizar o rastreio de estratégias de autorregulação emocional em crianças e adolescentes.
Hybrid closed-loop therapy in adults with type 1 diabetes and above target HbA1c: a real-world observational study.
Authors: S.J. Crabtree Thomas , Griffin Tomas P , W. Yap Yew , Narendran Parth , Gallen Gerladine , Furlong Niall , Cranston Iain , Chakera Ali J , Philbey Chris , Karamat Muhammad Ali , Saraf Sanjay , Kamaruddin Shafie , Gurnell Eleanor , Chapman Alyson , Hussain Sufyan , Elliott Jackie , Leelarathna Lalantha , Ryder Robert E.J. , Hammond Peter , Lumb Alistair , Choudhary Pratik , Wilmot Emma G. 
Published: August 2023

<p> </p>
<p>We explored longitudinal changes associated with switching to hybrid closed loop (HCL) insulin delivery systems in adults with type 1 diabetes and elevated HbA1c levels despite the use of intermittently scanned continuous glucose monitoring (isCGM) and insulin pump therapy. </p>
<p><em>Research Design and Methods</em></p>
<p>We undertook a pragmatic, pre-planned observational study of participants included in the NHS England closed-loop pilot. Adults using isCGM and insulin pump across 31 diabetes centers in England with a HbA1c ≥8.5%, who were willing to commence HCL therapy were included. Outcomes included change in HbA1c; sensor glucometrics; Diabetes Distress Score; Gold Score (hypoglycemia awareness); acute event rates and user opinion of HCL. </p>
<h3>Results</h3>
<p>In total, 570 HCL users were included; median age 40 (IQR 29-50) years, 67% female, and 85% White. Baseline HbA1c was 9.4±0.9% [78.9±9.1mmol/mol] with a median follow-up of 5.1 (IQR 3.9-6.6) months. Of 520 users continuing HCL at follow-up, mean adjusted HbA1c reduced by 1.7% (95% CI 1.5, 1.8, P<0.0001) [18.1mmol/mol; 95%CI 16.6, 19.6; P<0.0001]. Time in range (70-180mg/dL) increased from 34.2% to 61.9% (P<0.001). Individuals with HbA1c of ≤58mmol/mol rose from 0% to 39.4% (P<0.0001) and those achieving ≥70% glucose time in range and <4% time below range increased from 0.8% to 28.2% (P<0.0001). Almost all participants rated HCL therapy as having a positive impact on quality of life (94.7%, 540/570).</p>
<h3>Conclusions</h3>
<h3>Use of HCL is associated with improvements in HbA1c, time in range, hypoglycemia and diabetes-related distress and quality of life in people with type 1 diabetes in the real-world. </h3>
Geração automatizada multicritério: estudo de caso em casas unifamiliares de interesse social
Authors: Pizzetti Mariano Pedro Oscar , Vaz Carlos Eduardo Verzola 
Published: August 2023

A pesquisa visa desenvolver e aplicar um processo de projeto automatizado multicritério na formação de casas de interesse social no Brasil. A criação do algoritmo foi executada em um software de modelagem e programação, utilizando como estratégia processos de programação visual e de script. Para tanto, o algoritmo foi estruturado em quatro etapas: inicialmente, são construídas as dimensões do terreno; na sequência, é organizada uma composição a partir de regras; após, são adicionadas características arquitetônicas (janelas, portas); e por fim, a composição passa por um conjunto de simulações, visualizações e coleta de dados sensíveis, a saber: orçamento — por meio do CUB e CUG — e distribuição da luz do dia e radiação incidente nas fachadas. Ao final, o processo torna-se possível criar de forma autônoma um anteprojeto diferente para cada momento em que a programação é acionada. As características e dados quantitativos do partido são salvos, permitindo assim, a comparação entre os diferentes resultados. Para validar a programação, buscou-se utilizá-la na construção de uma casa de interesse social para um concurso de arquitetura no Brasil. Além da experiência de solucionar um problema real de arquitetura com a programação, foi possível abordar como o uso de tecnologias e sistemas automatizados podem ser aplicados nas práticas contemporâneas do projeto. Demonstra-se assim, como a utilização da programação possibilita não só expandir a imaginação por meio da visualização de composições não planejadas, mas também permite a tomada de decisões de modo mais assertivo. Considerando também as avaliações do concurso pode-se trazer a discussão sob a ótica de quais aspectos e critérios relevantes uma arquitetura pode ser julgada, considerando as ponderações da banca de arquitetos avaliadores do concurso.
Komponen Mu’jam Al Lughah Al Arabiyyah Al Mu’ashiroh ( Studi Analisis Ditinjau dari Ilmu Leksikografi )
Authors: Ryan Nurdiana  
Published: August 2023

Penelitian ini bertujuan untuk mendeskripsikan komponen kamus Mu’jam Al Lughah Al Arabiyyah Al Mu’ashiroh. Kamus ini adalah kamus ekabahasa yang memuat makna leksikal bahasa arab kontemporer. Penelitian ini menggunakan jenis penelitian kualitatif deskriptif dengan metode kepustakaan. Penelitian ini berusaha untuk menguraikan analisis komponen kamus yang ditulis oleh Ahmad Mukhtar Umar dimana kamus ini sangat populeh di mesir dan di dunia arab umumnya. Data dikumpulkan melalui membaca dan menganalisis dengan cermat melalui analisis konten untuk mengetahui komponen kamus secara komprehensif. Temuannya adalah kamus ini cukup ideal dimana komponennya terdiri dari bagian awal, bagian inti, dan bagian akhir yang cukup memuat informasi penting terkait cara penggunaannya dan contoh kontekstualnya.
Kata kunci : Kamus, Mu’jam Al Lughah Al Arabiyyah Al Mu’ashiroh, Leksikografi
Implementation of the Association Rule Method using Apriori Algorithm to Recognize The Purchase Pattern of Pharmacy Drugs “XYZ”
Authors: Utami Fadhila Putri , Jananto Arief 
Published: August 2023

XYZ Pharmacy is a Special Health Service Point for employees and retirees of the XYZ company. This pharmacy carries out the process of buying and selling drugs by providing various types of drugs. The number of sales transactions in each day, resulting in sales data will increase over time. If the data is left alone, the pile of data will only become archives that are not utilized. By carrying out the data mining process, this data can be used to produce information that can be used to increase sales transactions at XYZ Pharmacy. The method used in this study is the Association Rule which functions to analyze the most sold and purchased drugs simultaneously, this analysis will be reviewed from drug sales transaction data at the XYZ Pharmacy. The application of the a priori algorithm in this study succeeded in finding the most item combinations based on transaction data and then formed an association pattern from the item combinations. By knowing the types of drugs that are often purchased together through identification of purchasing patterns, it is very useful for the XYZ Pharmacy to maintain the availability of the drugs.
Design and Build a Travel Taxi Ordering Application Using the FIFO Algorithm and the Flutter Framework
Authors: Susanto Susanto , Mutiah Nurul , Prawira Dian 
Published: August 2023

Antrian merupakan suatu keadaan dimana seseorang harus menunggu gilirannya untuk mendapatkan pelayanan. Seringkali antrian menjadi suatu masalah bagi masyarakat ataupun sebuah perusahaan yang memberikan pelayanan. Hal ini terjadi pada PT. Citra Surya Sejati, dimana proses pemesanan taksi masih manual dan disana penumpang harus mengantri untuk mendapatkan pelayanan. Disisi lain PT. Citra Surya Sejati juga mengalami permasalahan dimana pencatatan laporan pemesanan taksi masih menggunakan cara manual dengan mencatatnya dibuku, sehingga diperlukan sebuah sistem untuk mengatasi masalah tersebut. Sistem yang akan dibuat oleh peneliti menggunakan algoritma First In First Out untuk konfirmasi pesanannya, sehingga penumpang yang pertama kali memesan akan pertama kali mendapatkan pelayanan. Hasil dari penelitian ini berupa aplikasi berbasis Mobile untuk penumpang, sedangkan admin berbasis Website. Sistem ini telah dilakukan pengujian dengan menggunakan metode black box testing. Seluruh fungsionalitas sistem berjalan sesuai dengan perancangan yang telah dibuat sebelumnya dan antarmuka sistem memperoleh persentase 81,64% yang masuk ke dalam kategori Baik Sekali. Queuing is a situation where a person has to wait for his turn to get service. Often queues become a problem for the community or a company that provides services. This happened to PT. Citra Surya Sejati, where the taxi ordering process is where passengers have to queue to get service. On the other hand PT. Citra Surya Sejati also experienced a problem where the recording of taxi order reports still used the manual method by recording them in a book, so a system was needed to overcome this problem. The system that the researcher will create uses the First In First Out algorithm to confirm orders, so that passengers who order for the first time will receive service first. The results of this study are in the form of a Mobile-based application for passengers, while the Website-based admin. This system has been tested using the black box testing method. All system functionality goes according to the design that has been made before and the system interface gets a percentage of 81.64% which is in the Very Good category.