bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical management of seizures in patients with meningiomas: Efficacy of surgical resection for seizure control and patient-tailored postoperative anti-epileptic drug management
Authors: Peart Rodeania , Melnick Kaitlyn , Cibula Jean , Walbert Tobias , Gerstner Elizabeth R , Rahman Maryam , Peters Katherine B , Mrugala Maciej , Ghiaseddin Ashley 
Published: June 2023

Abstract
Meningiomas are the most common primary intracranial tumor. They are slow growing and often incidentally found tumors that arise from the arachnoid villi. As they grow, they have a greater likelihood of becoming symptomatic with seizures being one of the most clinically significant symptoms. Seizures are more likely to present as a symptom of larger meningiomas and meningiomas that compress cortical areas particularly those in non-skull base locations. These seizures are often managed medically, utilizing the same anti-seizure medications that are used to treat other causes of epilepsy. We discuss common anti-seizure medications used including valproate, phenobarbital, carbamazepine, phenytoin, lacosamide, lamotrigine, levetiracetam and topiramate and their common adverse effects. The goal of pharmacotherapy for seizure control is to maximize seizure control while minimizing the adverse effects of the medication. The decision to provide medical management is dependent on individual seizure history and plans for surgical treatment. Patients who did not require seizure prophylaxis before surgery are commonly prescribed seizure prophylaxis postoperatively. Symptomatic meningiomas not controlled by medical management alone are commonly evaluated for surgical resection. The efficacy of surgical resection in providing seizure freedom is dependent on several features of the tumor including tumor size, the extent of the peritumoral edema, the number of tumors, sinus infiltration and the degree of resection.
Pediatric meningiomas: A literature review and diagnostic update
Authors: Tauziède-Espariat Arnault , Pfister Stefan M , Mawrin Christian , Sahm Felix 
Published: June 2023

AbstractBackgroundMeningiomas have always represented the most frequently observed primary central nervous system (CNS) tumor in adults. Multiple advances concerning the genetic and epigenetic characterizations of adult meningiomas have been made over the last few years, and a new proposition for integrated histo-molecular grading has recently been offered in the literature. Pediatric meningiomas represent a very small proportion of all diagnosed meningiomas. New literature has determined that pediatric meningiomas are clinically, histopathologically, genetically, and epigenetically distinct from their adult counterparts. Herein, we reviewed and performed a synthesis of literature investigating pediatric meningiomas. We then compared and contrasted pediatric meningiomas with their adult counterparts.MethodsWe performed an extensive review of cases from English-language literature available in Pubmed using the keywords “pediatric” and “meningioma” as well as “children” and “meningioma”. We reviewed and analyzed fifty-six papers that include 498 cases.ResultsThis literature review revealed that pediatric meningiomas differ from their adult counterparts clinically (location, sex ratio) and also in terms of etiology (germline mutations), histopathology (a greater incidence of clear cell subtype), molecular biology, and epigenetics.ConclusionsPediatric meningiomas are, like other brain tumors (such as low-grade and high-grade gliomas), clinically and biologically different from their adult counterparts. Further studies are needed to better understand the tumorigenesis of pediatric meningiomas and to optimize their stratification in terms of outcome and therapeutic strategy.
Reengagement for Long-Term Smoking-Cessation In Military Personnel, Retirees, Family Members (TRICARE): A Randomized Trial
Authors: Klesges Robert C , Talcott G Wayne , Little Melissa A , Mallawaarachchi Indika V , Wang X -Q , Aycock Chase A , Patience Marc A , Halbert Jennifer P , Wiseman Kara P , Ebbert Jon O 
Published: June 2023

Abstract

Introduction
We sought to determine what type of treatment reengagement after smoking relapse would increase long-term cessation.

Aims and Methods
Participants were military personnel, retirees, and family members (TRICARE beneficiaries) recruited across the United States from August 2015 through June 2020. At baseline, consented participants (n = 614) received a validated, four-session, telephonic tobacco-cessation intervention with free nicotine replacement therapy. At the 3-month follow-up, 264 participants who failed to quit or relapsed were offered the opportunity to reengage in cessation. Of these, 134 were randomized into three reengagement conditions: (1) repeat initial intervention (“recycle”), (2) Smoking reduction with eventual cessation goal (“rate reduction”), or (3) Choose #1 or #2 (“choice”). Prolonged abstinence and 7-day point prevalence abstinence were measured at 12 months.

Results
Despite being in a clinical trial advertised as having the opportunity for reengagement, only 51% (134 of the 264) of participants who still smoked at 3-month follow-up were willing to reengage. Overall, participants randomized to recycle had higher prolonged cessation rates at 12 months than rate reduction conditions (OR = 16.43, 95% CI: 2.52 to 107.09, Bonferroni adjusted p = .011). When participants who randomly received recycle or rate reduction were pooled, respectively, with participants who chose recycle or rate reduction in the Choice group, recycle had higher prolonged cessation rates at 12 months than rate reduction (OR = 6.50, 95% CI: 1.49 to 28.42, p = .013).

Conclusions
Our findings suggest service members and their family members who fail to quit smoking but are willing to reengage in a cessation program are more likely to benefit from repeating the same treatment.

Implications
Finding methods that are both successful and acceptable to reengage people who smoke who want to quit can have a significant impact on improving the health of the public by reducing the portion of the population who smoke. This study suggests that repeating established cessation programs will result in more people ready to quit successfully achieving their goal.
Strigolactones in Rhizosphere Communication: Multiple Molecules With Diverse Functions
Authors: Kee Yee Jia , Ogawa Satoshi , Ichihashi Yasunori , Shirasu Ken , Yoshida Satoko 
Published: June 2023

Abstract
Strigolactones (SLs) are root-secreted small molecules that influence organisms living in the rhizosphere. While SLs are known as germination stimulants for root parasitic plants and as hyphal branching factors for arbuscular mycorrhizal fungi, recent studies have also identified them as chemoattractants for parasitic plants, sensors of neighboring plants and key players in shaping the microbiome community. Furthermore, the discovery of structurally diverged SLs, including so-called canonical and non-canonical SLs in various plant species, raises the question of whether the same SLs are responsible for their diverse functions ‘in planta’ and the rhizosphere or whether different molecules play different roles. Emerging evidence supports the latter, with each SL exhibiting different activities as rhizosphere signals and plant hormones. The evolution of D14/KAI2 receptors has enabled the perception of various SLs or SL-like compounds to control downstream signaling, highlighting the complex interplay between plants and their rhizosphere environment. This review summarizes the recent advances in our understanding of the diverse functions of SLs in the rhizosphere.
Keeping Your Mouth Shut: Spiraling Self-Censorship in the United States
Authors: Gibson James L , Sutherland Joseph L 
Published: June 2023

Abstract
Over the period from the heyday of McCarthyism to the present, the percentage of the American people not feeling free to express their views has tripled. In 2020, more than four in ten people engaged in self-censorship. Our analyses of over-time and cross-sectional variability suggest that, first, self-censorship is connected to affective polarization among the mass public, with greater polarization associated with more self-censorship. Second, levels of mass opposition to full civil liberties bear no relationship to self-censorship. Third, those who perceive a more repressive government are slightly more likely to self-censor. Fourth, conservatives report engaging in more self-censorship than liberals (but this is not true when comparing Republicans with Democrats). Together, these findings suggest that one's larger macro-environment may have little to do with self-censorship. Instead, micro-environment sentiments, such as worrying that expressing unpopular views will isolate and alienate people from their friends, family, and neighbors, may be the driver of self-censorship.
Equidistribution of primitive lattices in ℝn
Authors: Horesh Tal , Karasik Yakov 
Published: June 2023

Abstract
We count primitive lattices of rank d inside $\mathbb{Z}^{n}$ as their covolume tends to infinity, with respect to certain parameters of such lattices. These parameters include, for example, the subspace that a lattice spans, namely its projection to the Grassmannian; its homothety class and its equivalence class modulo rescaling and rotation, often referred to as a shape. We add to a prior work of Schmidt by allowing sets in the spaces of parameters that are general enough to conclude the joint equidistribution of these parameters. In addition to the primitive d-lattices Λ themselves, we also consider their orthogonal complements in $\mathbb{Z}^{n}$, ${\Lambda}^{\perp}$, and show that the equidistribution occurs jointly for Λ and ${\Lambda}^{\perp}$. Finally, our asymptotic formulas for the number of primitive lattices include an explicit bound on the error term.
CCL20 inhibition for treating inflammation in ankylosing spondylitis
Authors: Won Eun Jeong , Kim Hui-Ju , Lee Yu Jeong , Kim Moon-Ju , Lee Hae-In , Jang Hyun Hee , Kim Seong Hoon , Kang Ji-Hyoun , Park Ki-Jeong , Shim Seung Cheol , Jo Sungsin , Kim Tae-Hwan , Kim Tae-Jong 
Published: June 2023

Abstract

Objectives
Th17 cells are known to play a significant role in AS. C-C motif chemokine ligand 20 (CCL20) binds to C-C chemokine receptor 6 (CCR6) on Th17 cells, promoting their migration to inflammation sites. The aim of this research is to examine the effectiveness of CCL20 inhibition in treating inflammation in AS.

Methods
Mononuclear cells from peripheral blood (PBMC) and SF (SFMC) were collected from healthy individuals and AS. Flow cytometry was used to analyse cells producing inflammatory cytokines. CCL20 levels were determined using ELISA. The impact of CCL20 on Th17 cell migration was verified using a Trans-well migration assay. The in vivo efficacy of CCL20 inhibition was evaluated using an SKG mouse model.

Results
The presence of Th17 cells and CCL20 expressing cells was higher in SFMCs from AS patients compared with their PBMCs. The CCL20 level in AS SF was significantly higher than in OA patients. The percentage of Th17 cells in PBMCs from AS patients increased when exposed to CCL20, whereas the percentage of Th17 cells in SFMCs from AS patients decreased when treated with CCL20 inhibitor. The migration of Th17 cells was found to be influenced by CCL20, and this effect was counteracted by the CCL20 inhibitor. In the SKG mouse model, the use of CCL20 inhibitor significantly reduced joint inflammation.

Conclusion
This research validates the critical role of CCL20 in AS and suggests that targeting CCL20 inhibition could serve as a novel therapeutic approach for AS treatment.
Letters of wishes and trustee decision-making after Grand View v Wong
Authors: Avis Robert , Denham-Smith Tom 
Published: June 2023

Abstract
This article examines the implications of Grand View Private Trust Company & Anor v Wong & Ors on the role of expressions of wishes by a settlor as to a trustee’s exercise of discretionary dispositive powers. Specifically, it considers the difference in weight, if any, to be placed by a trustee on contemporaneous and subsequent wishes of a settlor in a trustee’s decision-making process. It also considers the balancing of the wishes and needs of a beneficiary in this context.
Why several when one can unite them all? Integrative taxonomic revision of Indo-Pacific freshwater pipefish (Nerophinae)
Authors: Haÿ Vincent , Mennesson Marion I , Lord Clara , Keith Philippe 
Published: June 2023

Abstract
The family Syngnathidae (seahorses, sea dragons and pipefishes) is a fascinating group. Species are mostly distributed in marine coastal waters, but about 30 species inhabit Indo-Pacific tropical island rivers. There are currently six freshwater genera of Nerophinae (trunk-brooders): Belonichthys, Coelonotus, Doryichthys, Lophocampus, Microphis and Oostethus. Unlike other Syngnathidae, freshwater pipefish have been little studied; the taxonomy of Nerophinae is unclear and only based on morphomeristic data. The purpose of our study is to undertake a revision of this group based on an integrative taxonomy approach. By combining molecular data from four mitochondrial markers (5415 bp), morphomeristic data with a character mapping study and ecological data, we now recognize a single genus as valid, Microphis, as opposed to the six previously accepted. Our results also reveal one new candidate species, Microphis nicoleae sp. nov., and the resurrection of two others: Microphis torrentius and Microphis vaillantii. This study shows the relevance of integrative taxonomy for higher taxa delineation, using data integration by congruence.
Clinical efficacy and safety of atezolizumab plus bevacizumab versus lenvatinib in the treatment of advanced hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Du Sihao , Cao Ke , Wang Zhenshun , Lin Dongdong 
Published: June 2023

Background:
Assess the effectiveness and safety of treatment options atezolizumab plus bevacizumab (Atez/Bev) or lenvatinib in clinical practice for patients with advanced hepatocellular carcinoma (HCC) patients.

Methods:
To compare the effectiveness of Atez/Bev and lenvatinib in treating advanced HCC, we systematically searched the PubMed, EMBASE, and Web of Science databases. We utilized Review Manager 5.3 to extract and analyze the data.

Results:
The present systematic review included 8 nonrandomized studies comprising a total of 6628 cases. There was no significant difference in 0.5-, 1-, 1.5-year OS rates and 0.5-, 1-year PFS rates between the 2 groups. However, patients with HCC caused by viral hepatitis would benefit more from the Atez/Bev therapy (hazard ratio = 0.75, 95% confidence interval: 0.63–0.89) but patients with a Child–Pugh class B liver function would benefit more from lenvatinib (hazard ratio = 1.70, 95% confidence interval: 1.07–2.70). At the same time, there are no major differences in safety between the 2 treatment options.

Conclusion:
Our study did not find any significant difference in effectiveness and safety between Atez/Bev and lenvatinib. However, Additional verification is required to determine whether these 2 therapeutic approaches have varying effects on distinct populations.
A Novel Approach and Apparatus for the Measurement and Evaluation of the Quality of Cardiopulmonary Resuscitation
Authors: Bakshi Ishnoor Kaur 
Published: June 2023

AbstractCardiac arrest can happen unexpectedly in any place and situation. Cardiopulmonary resuscitation (CPR) is the recommended procedure to be performed in order to maintain the proper blood supply to the brain and prevent death. Cardiopulmonary resuscitation is commonly taught during first-aid courses, but most people do not practice it and therefore might not be able to provide proper assistance to someone suffering cardiac arrest in an emergency. People should be able to practice the procedure on their own in order to learn it properly and be prepared. This means having a feedback system to assess the quality of their training. This research experiment developed and tested a system, capable of assessing the quality of the cardiopulmonary resuscitation procedure and tested it with volunteers with different training and experience and showed that constant practice and evaluation of the procedure significantly improve the ability of the subject to administer it properly.Significance StatementThis research developed and tested a new system to monitor the effectiveness of cardiopulmonary resuscitation during training and practicing for first responders in the case of cardiac arrest.
Meta-omics analyses of dual substrate enrichment culturing of nitrous oxide respiring bacteria suggest that attachment and complex polysaccharide utilisation contributed to the ability ofCloacibacteriumstrains to reach dominance
Authors: Vick Silas H.W. , Jonassen Kjell Rune , Arntzen Magnus Ø. , Lycus Pawel , Bakken Lars R 
Published: June 2023

AbstractBioengineering soil metabolism by inoculation is an emerging approach to enhance plant growth and strengthen specific functions such as N2O reduction in order to reduce climate forcing. The use of organic wastes as substrates and carriers of microbial biomass has proven to be a viable approach to improving effectiveness and economic viability. A key factor in the success of this approach lies in selection of microbes capable of growth and survival in both organic wastes as well as soils, and which are tolerant of the rapid environmental fluctuations such fertilisations involve. A dual substrate, N2O-enrichment experiment, switching between soil and organic waste as substrates has yieldedCloacibacteriumisolates which grow well in organic wastes and retain significant N2O reduction capacity when applied to soils. However, an understanding of the genetic and phenotypic characteristics utilised by these enrichment winners to dominate under such conditions remains unexplored. Here we have performed a multi-omics examination of the enrichment cultures, using both metagenomics and metaproteomics to probe the genetic basis and expressed proteins which may contribute to the success ofCloacibacteriumin the enrichments, and their survival in soil. These omics results show an increase in complex carbohydrate metabolism, chemotaxis and motility genes throughout the enrichment as well as the expression of gliding motility proteins and polysaccharide utilization loci proteins byCloacibacteriumorganisms. Taken together this suggests that attachment and complex polysaccharide utilisation may be key processes allowingCloacibacteriumto tolerate the stresses of a changing environment during transfers between digestate and soil.
Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess
Authors: Schiffer Lina , Oestlund Imken , Snoep Jacky , Gilligan Lorna C. , Taylor Angela E. , Sinclair Alexandra J. , Singhal Rishi , Freeman Adrian , Ajjan Ramzi , Tiganescu Ana , Arlt Wiebke , Storbeck Karl-Heinz 
Published: June 2023

AbstractAldo-keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both classic and 11-oxygenated androgens. In adipose tissue, AKR1C3 is co-expressed with 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which catalyses the local activation of glucocorticoids but also the inactivation of 11-oxygenated androgens, and thus has the potential to counteract AKR1C3. Using a combination ofin vitroassays andin silicomodelling we show that HSD11B1 attenuates the biosynthesis of the potent 11-oxygenated androgen, 11-ketotestosterone, by AKR1C3. Employingex vivoincubations of human female adipose tissue samples we show that inhibition of HSD11B1 results in the increased peripheral biosynthesis of 11-ketotestosterone. Moreover, circulating 11KT increased 2-3 fold in individuals with type 2 diabetes after receiving the selective oral HSD11B1 inhibitor AZD4017 for 35 days, thus confirming that HSD11B1 inhibition results in systemic increases in 11KT concentrations. Our findings show that HSD11B1 protects against excess 11KT production by adipose tissue, a finding of particular significance when considering the evidence for adverse metabolic effects of androgens in women. Therefore, when targeting glucocorticoid activation by HSD11B1 inhibitor treatment in women, the consequently increased generation of 11-ketotestosterone may offset beneficial effects of decreased glucocorticoid activation.Graphical Abstract
Bridging Imaging Users to Imaging Analysis - A community survey
Authors: Sivagurunathan Suganya , Marcotti Stefania , Nelson Carl J , Jones Martin L , Barry David J , Slater Thomas J A , Eliceiri Kevin W , Cimini Beth A 
Published: June 2023

ABSTRACTThe “Bridging Imaging Users to Imaging Analysis” survey was conducted in 2022 by the Center for Open Bioimage Analysis (COBA), Bioimaging North America (BINA), and the Royal Microscopical Society Data Analysis in Imaging Section (RMS DAIM) to understand the needs of the imaging community. Through multi-choice and open-ended questions, the survey inquired about demographics, image analysis experiences, future needs, and suggestions on the role of tool developers and users. Participants of the survey were from diverse roles and domains of the life and physical sciences. To our knowledge, this is the first attempt to survey cross-community to bridge knowledge gaps between physical and life sciences imaging. Survey results indicate that respondents’ overarching needs are documentation, detailed tutorials on the usage of image analysis tools, user-friendly intuitive software, and better solutions for segmentation, ideally in a format tailored to their specific use cases. The tool creators suggested the users familiarize themselves with the fundamentals of image analysis, provide constant feedback, and report the issues faced during image analysis while the users would like more documentation and an emphasis on tool friendliness. Regardless of the computational experience, there is a strong preference for ‘written tutorials’ to acquire knowledge on image analysis. We also observed that the interest in having ‘office hours’ to get an expert opinion on their image analysis methods has increased over the years. In addition, the community suggests the need for a common repository for the available image analysis tools and their applications. The opinions and suggestions of the community, released here in full, will help the image analysis tool creation and education communities to design and deliver the resources accordingly.
Structural insight into CD93 recognition by IGFBP7
Authors: Xu Yueming , Sun Yi , Zhu Yuwen , Song Gaojie 
Published: June 2023

ABSTRACTThe CD93/IGFBP7 axis are key factors expressed in endothelial cells (EC) that mediate EC angiogenesis and migration. Upregulation of them contributes to tumor vascular abnormality and blockade of this interaction promotes a favorable tumor microenvironment for therapeutic interventions. However, how these two proteins associated to each other remains unclear. In this study, we solved the human CD93–IGFBP7 complex structure to elucidate the interaction between the EGF1domain of CD93 and the IB domain of IGFBP7. Mutagenesis studies confirmed the binding interactions and specificities. Cellular and mouse tumor studies demonstrated the physiological relevance of the CD93–IGFBP7 interaction in EC angiogenesis. Our study provides hints for development of therapeutic agents to precisely disrupt unwanted CD93–IGFBP7 signaling in the tumor microenvironment. Additionally, analysis of the CD93 full-length architecture provides insights into how CD93 protrudes on the cell surface and forms a flexible platform for binding to IGFBP7 and other ligands.