bluuebunny/crossref_metadata_2025_split huggingface dataset:
User-relevant factors influencing the prosthesis use of persons with a transfemoral amputation or knee-disarticulation: A meta-synthesis of qualitative literature and focus group results
Authors: Bosman Charlotte E. , van der Sluis Corry K. , Geertzen Jan H. B. , Kerver Nienke , Vrieling Aline H. 
Published: January 2023

ObjectivePersons with a transfemoral amputation or knee-disarticulation are heavily reliant on an adequate set of components for their prosthesis. To improve the process of adjusting the specific prosthetic properties to the expectations of the prosthesis users, it is of importance to first identify which factors have an influence on prosthesis use. Therefore, we aimed to identify factors that influence prosthesis use in adults with a transfemoral amputation or knee-disarticulation.MethodsA qualitative meta-synthesis was conducted by searching five databases (last update January 20th2022). Studies were considered eligible if they contained qualitative data about adult persons with a transfemoral amputation or knee-disarticulation with experience in using a prosthesis and focused on the users’ opinions. All eligible studies were independently screened by two reviewers. The results sections of the included studies were entered in Atlas.ti software (v8) and coded using the framework approach. The quality of the included studies was assessed using the Critical Appraisal Skills Program (CASP) qualitative research checklist. Results of the meta-synthesis were validated with prosthesis users (n = 8) in a focus group.ResultsOut of 5757 articles, 14 studies were included. An overview of seven themes (‘prosthesis related’; ‘rehabilitation, costs and prosthetist’; ‘mental’; ‘physical’; ‘social’; ‘activities and participation’ and ‘walking’) containing 84 factors was created. Ten factors were added during the focus group, resulting in an overview of 94 factors that may influence the prosthesis use of lower-limb prosthesis users. Participants would like more user-involvement from the rehabilitation team. The development of a patient decision aid could help this process in the future.ConclusionThe large number of factors demonstrates that there is a great variety between prosthesis users and the factors that influence their prosthesis use. Therefore, it is important to take individual preferences into account for the selection of a new prosthesis.
Associated factors of pelvic organ prolapse among patients at Public Hospitals of Southern Ethiopia: A case-control study design
Authors: Borsamo Asfaw , Oumer Mohammed , Worku Ayanaw , Asmare Yared 
Published: January 2023

Background
Pelvic organ prolapse (POP) is the descent of the vaginal wall, cervix, uterus, bladder, and rectum downward into the vaginal canal. It occurs owing to the weakness of the structures supporting and keeping pelvic organs in anatomic position. Prolapse occurs due to exposure to risk factors; women in developing countries are highly predisposed to the risk factors of the prolapse. No study assesses POP in Southern Ethiopia.

Methods
A case-control study design was employed in 369 participants (123 cases and 246 controls) of seven randomly selected Public Hospitals of Southern Ethiopia from February-June, 2020, using a structured questionnaire. All patients diagnosed with prolapse (stage I- IV) were included as cases; patients free of prolapse (stage 0) were taken as controls after physicians had performed a diagnosis and vaginal examination. Bivariate and multivariable logistic regression analyses were performed using SPSS.

Results
In this study, after adjusting for covariates, age of the women ≥ 45 years (AOR = 5.33, 95% CI: 1.47, 9.05), underweight (AOR= 4.54, 95% CI: 1.4, 15.76), low income (AOR = 2.5, 95% CI:1.14, 5.59), parity ≥5 (AOR = 5.2, 95% CI: 2.2, 12.55), assisted vaginal delivery (AOR= 4, 95% CI: 1.55, 11.63), instrumental delivery (AOR= 3.5, 95% CI:1.45, 84), sphincter damage and vaginal tear (AOR = 3.2, 95% CI:1.44,7.1), carrying heavy loads (AOR= 2.5, 95% CI:1.2, 5.35), and prolonged labor ≥24 hours (AOR = 3.3, 95% CI:1.12, 97) were significant associated factors of prolapse. The odds of developing prolapse is lower among women attended school. Most(84.55%) of the women with prolapse were delayed for the treatments and only surgical interventions were done as treatments. Most of them claimed lack of social support, lack of money, and social stigma as the main reasons for the delay in seeking treatments.

Conclusions
Older age, low educational status, underweight, low income, higher parity, assisted vaginal delivery, prolonged labor, sphincter damage, and carrying heavy loads were significant associated factors of POP. It is better to screen older age women by doing campaigns against the prolapse. Also, responsible bodies should work on raising awareness of women as well as awareness of the community about the prolapse through expanding health education. Moreover, informing women to practice pelvic muscle training daily, raising women’s income to empower them, and help of family members to reduce carrying an overload of mothers are recommended.
The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands
Authors: Declercq Eugene , Wolterink Anneke , Rowe Rachel , de Jonge Ank , De Vries Raymond , Nieuwenhuijze Marianne , Verhoeven Corine , Shah Neel 
Published: January 2023

Objective
To examine cross-national differences in gestational age over time in the U.S. and across three wealthy countries in 2020 as well as examine patterns of birth timing by hour of the day in home and spontaneous vaginal hospital births in the three countries.

Methods
We did a comparative cohort analysis with data on gestational age and the timing of birth from the United States, England and the Netherlands, comparing hospital and home births. For overall gestational age comparisons, we drew on national birth cohorts from the U.S. (1990, 2014 & 2020), the Netherlands (2014 & 2020) and England (2020). Birth timing data was drawn from national data from the U.S. (2014 & 2020), the Netherlands (2014) and from a large representative sample from England (2008–10). We compared timing of births by hour of the day in hospital and home births in all three countries.

Results
The U.S. overall mean gestational age distribution, based on last menstrual period, decreased by more than half a week between 1990 (39.1 weeks) and 2020 (38.5 weeks). The 2020 U.S. gestational age distribution (76% births prior to 40 weeks) was distinct from England (60%) and the Netherlands (56%). The gestational age distribution and timing of home births was comparable in the three countries. Home births peaked in early morning between 2:00 am and 5:00 am. In England and the Netherlands, hospital spontaneous vaginal births showed a generally similar timing pattern to home births. In the U.S., the pattern was reversed with a prolonged peak of spontaneous vaginal hospital births between 8:00 am to 5:00 pm.

Conclusions
The findings suggest organizational priorities can potentially disturb natural patterns of gestation and birth timing with a potential to improve U.S. perinatal outcomes with organizational models that more closely resemble those of England and the Netherlands.
Effects of riboflavin/ultraviolet-A scleral collagen cross-linking on regional scleral thickness and expression of MMP-2 and MT1-MMP in myopic guinea pigs
Authors: Lv Xiaotong , Lai Lingbo , Xu Yushan , Sun Mingshen , Li Yu , Song Yanzheng , Wang Ningli , Zhang Fengju 
Published: January 2023

Objective
To investigate the effects of scleral collagen cross-linking (SXL) using riboflavin and ultraviolet A (UVA) light on the scleral thickness of different regions and expression of matrix metalloproteinase 2 (MMP-2) and membrane-type MMP-1 (MT1-MMP) in guinea pigs with lens-induced myopia.

Methods
Forty-eight 4-week-old guinea pigs were assigned to three groups (n = 16 per group): SXL group, lens-induced myopia (LIM) group, and control group. The sclera of the right eye of the guinea pig in the SXL group was surgically exposed, riboflavin was dropped on the treatment area for 10 minutes before the 30-minute UVA irradiation. The same surgical procedure was performed in the LIM group without UVA irradiation. The -10.00 D lenses were then placed on the right eyes of guinea pigs in the SXL and LIM groups for six weeks. The control group received no treatment. The left eyes were untreated in all groups. The ocular axial length (AXL) and refraction were measured at 4 weeks and 10 weeks of age. 10-week-old guinea pigs were sacrificed, and the right eyes were enucleated and evenly divided for preparation of hematoxylin and eosin (HE) stained sections, quantitative real-time polymerase chain reaction (qPCR) and western blotting. The scleral thickness of different regions was measured on HE stained sections. The temporal half of the sclera was harvested to measure the expression of MMP-2 and MT1-MMP by qPCR and western blotting.

Results
The AXL was significantly shorter, and the degree of myopic refraction was significantly lower in the SXL group than those in the LIM group at 10 weeks of age. The scleral thickness of the cross-linked area was significantly greater in the SXL group than that of the corresponding area in the LIM group, while the scleral thickness of the untreated nasal side was not significantly different between the SXL group and the LIM group. The expression of MMP-2 and MT1-MMP of the cross-linked sclera was significantly downregulated compared with that of the corresponding area in the LIM group.

Conclusion
Riboflavin/UVA SXL could slow myopia progression and thicken the cross-linked sclera in guinea pigs, which might be related to the downregulation of MMP-2 and MT1-MMP expression during the scleral remodeling process.
How health literacy relates to venous leg ulcer healing: A scoping review
Authors: Bouguettaya Ayoub , Gethin Georgina , Probst Sebastian , Sixsmith Jane , Team Victoria , Weller Carolina 
Published: January 2023

BackgroundThe level of personal health literacy of patients with venous leg ulcers is likely to affect their ability to self-manage their condition impacting on their adherence to treatment and influences healing and recovery outcomes.ObjectivesTo scope existing research that examined the level of health literacy in venous leg ulcer patients, to identify how this may link to self-management behaviours (particularly physical activity and compression adherence), and venous leg ulcer healing outcomes.MethodsThis scoping review was based on the PRISMA-ScR six-stage framework. We searched MEDLINE, EMBASE, the Cochrane Library, PsycInfo and Health, Open Grey, and Google Scholar for publications examining general and specific health literacy in those with venous leg ulcers and for those examining any potential links of health literacy with self-management/healing generally, published between 2000–2020. This search was guided by a published protocol; studies that described other types of ulcers or did not examine health literacy were excluded. After applying inclusion and exclusion criteria the initial search identified 660 articles.ResultsWe included five articles. Four studies used randomised controlled trials or experimental designs to test the effect of specific health literacy interventions on venous leg ulcer knowledge, compression therapy use, or healing outcomes. One study was a cross- sectional survey with qualitative elements, assessing health literacy in venous leg ulcer patients. Broadly, the research suggested that health literacy was suboptimal amongst those with venous leg ulcers, and health literacy interventions had limited effects on improving key venous leg ulcer specific outcomes.ConclusionThis review provides a synthesis of extant literature examining health literacy in patients with venous leg ulcers. We identified a dearth of literature investigating the value of general and specific health literacy interventions in this space. Most importantly, no recent research on general health literacy and venous leg ulcers was identified, despite strong theoretical utility to do so. The few studies identified largely indicated that targeting health literacy of patients with venous leg ulcers is a viable area of research and intervention, encouraging future researchers and clinicians to consider patient health literacy in venous leg ulcer management.
The influence of a mineral oil cationic nanoemulsion or perfluorohexyloctane on the tear film lipid layer and higher order aberrations
Authors: Habbe Kirsten Julia , Frings Andreas , Saad Amr , Geerling Gerd 
Published: January 2023

Purpose
To prospectively assess the effect of a single and regular application of either a cationic nanoemulsion of mineral oil (CN) or perfluorohexyloctane (F6H8) on the lipid layer of the tear film and higher order aberrations (HOA) in patients with Dry Eye Disease (DED).

Methods
Fifty-seven patients with a lipid layer thickness (LLT) ≤ 75 interferometric colour units (ICU) were included in the study. In group A (20 patients) the effect of a single drop of F6H8 or CN on HOA and LLT was assessed immediately after application and up to two hours later. For long term effects (Group B) 37 patients applied CN or F6H8 five times a day for 12 weeks. Measurement of LLT, HOA, non-invasive-tear-break-up-time (NIBUT) and meibography were assessed prior to as well as at 4 weeks and 12 weeks after initiation of treatment. Our study is registered in the “German Clinical Trials Register” under the trial number: DRKS00028696.

Results
CN led to an increase of the LLT from 46.8 ± 16.9 ICU to 76.3 ± 23.5 ICU (p = 0.021) and to an increase of HOA from 0.43 ± 0.06 μm to 0.48 ± 0.08 μm immediately after application (p = 0.027). There was no correlation between the increase of LLT and HOA (r = -0.04; p = 0.90). In group B an increase of LLT was observed in the F6H8 group from 45.8 ± 8.8 ICU at baseline to 66.7 ± 19.5 ICU at 12 weeks (p = 0.002). No changes of HOA were measured throughout the observation period in group B. After 12 weeks CN increased NIBUT from 9.9 ± 5.3 seconds to 15.5 ± 5.6 seconds (p = 0.04). F6H8 increased NIBUT from 12.4 ± 5.9 seconds to 16.9 ± 4.7 seconds (p = 0.02) after 12 weeks.

Conclusion
CN leads to a short-term increase in LLT and HOA, but only immediately after application. In contrast F6H8 does lead to an increase of LLT after regular long-term use but has no effect on HOA. The regular application of lipid-based products does not seem to decrease the quality of vision as measured in HOA. Instead, CN and F6H8, both are able to stabilize the tear film after regular application.
Cost-utility analysis of atezolizumab with bevacizumab in untreated unresectable or advanced hepatocellular carcinoma in France
Authors: Gaugain Loïg , Cawston Hélène , Dubois de Gennes Coline , Sanchez Alvares Javier , Nahon Pierre , Mazaleyrat Benjamin , Le Dissez Clément 
Published: January 2023

Background and aims
The IMbrave150 clinical trial assessed the efficacy and safety of atezolizumab in combination with bevacizumab (ATZ+BVA) versus sorafenib in adults with advanced/unresectable hepatocellular carcinoma, who have not received prior systemic treatment. Our aim was to assess the cost-effectiveness of ATZ+BVA versus sorafenib in France based on an updated prices and considering French National real-world data, to confirm the initial recommendations from the Heath Technology Assessment submission published in 2021, and provide additional visibility to decision-makers reflecting current clinical practice.

Methods
A partition survival model was developed to project clinical outcomes, quality of life, and costs of patients with HCC treated with ATZ+BVA versus sorafenib over a lifetime horizon. Survival outcomes were extrapolated via parametric functions for both treatment strategies. Quality of life (EQ-5D-5L, French tariffs) were sourced from IMbrave150. The Guyot method was considered as a scenario analysis by integrating retrospective real-world data extracted from the French Health Insurance Database to refine long term survival extrapolations.

Results
In the reference case, ATZ+BVA was associated with 0.61 additional Quality Adjusted Life Years (QALYs) compared to sorafenib (1.95 vs 1.35), and an incremental cost of €92,704. The incremental cost-utility ratio (ICUR) was 152,974 €/QALY gained. Adjusting the survival curves with French external evidence led to a 14% ICUR reduction (131,163 €/QALY).

Conclusions
ATZ+BVA is a cost-effective strategy based on the range recently published for the value of a QALY in France and offers better chances of survival to patients.
Determinants and predictors of mental health during and after COVID-19 lockdown among university students in Malaysia
Authors: Mir Imtiyaz Ali , Ng Shang Kuan , Mohd Jamali Muhammad Noh Zulfikri , Jabbar Mohammed AbdulRazzaq , Humayra Syeda 
Published: January 2023

Background
Young adults, particularly university students might be at greater risk of developing psychological distress, and exhibiting symptoms of anxiety and depression during the COVID-19 pandemic. The primary objective of this study was to explore and compare the determinants and predictors of mental health (anxiety and depression) during and after the COVID-19 lockdown among university students.

Methods
This was an observational, cross-sectional study with a sample size of 417 students. An online survey utilizing International Physical Activity Questionnaire–Short Form (IPAQ-SF), General Anxiety Disorder–7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) was distributed to Universiti Tunku Abdul Rahman students via Google forms.

Results
During lockdown, family income [χ2 (1, n = 124) = 5.155, p = 0.023], and physical activity (PA) [χ2 (1, n = 134) = 6.366, p = 0.012] were associated with anxiety, while depression was associated with gender [χ2 (1, n = 75) = 4.655, p = 0.031]. After lockdown, family income was associated with both anxiety [χ2 (1, n = 111) = 8.089, p = 0.004], and depression [χ2 (1, n = 115) = 9.305, p = 0.002]. During lockdown, family income (OR = 1.60, p = 0.018), and PA (OR = 0.59, p = 0.011) were predictors for anxiety, while gender (OR = 0.65, p = 0.046) was a predictor for depression. After lockdown, family income was a predictor for both anxiety (OR = 1.67, p = 0.011), and depression (OR = 1.70, p = 0.009).

Conclusion
Significant negative effects attributed to the COVID-19 lockdown, and certain factors predisposed to the worsening of mental health status in university students. Low family income, PA, and female gender were the major determinants and predictors linked to anxiety and depression.
Untwine
Authors: Leger Shewonda 
Published: January 2023

In her novel Untwine, Edwidge Danticat uses Giselle’s trauma to help readers understand the value of reflecting on past memories. Giselle’s trauma positioned her to orient, disorient, and reorient to find ways of healing and to understand her identities. To expand on what it means to orient, disorient, and reorient, the author builds off Sara Ahmed’s theory around reorientation to show how forms of discomfort force us to question where our experiences have positioned us and also to interrogate and look back at our lived experiences to understand the present in order to move forward from trauma. The historical moments that Danticat includes in Giselle’s narrative also works as a collective Haitian history. Danticat’s use of historical narratives offers a more comprehensive picture of Haitian cultural identity and how those historical narratives connect to our identities.
Peer socialization of male adolescents in digital games: Achievement, competition, and harassment
Authors: Waechter Natalia , Meschik Markus 
Published: January 2023

Abstract
Socialization theories suggest that, due to social change and technological transformation, peers and media have become important institutions of socialization for young people. Assuming that male adolescents use digital games for processes of peer self-socialization, this article investigates the values they mediate in digital games and how these values are related to their practice (with a focus on harassment) in digital games. Applying a qualitative research design, 36 male adolescents who frequently play various (multiplayer) online games were interviewed about their values and practices when gaming. The results show that the young gamers share individualistic values promoting performance, competition, and achievement, which seem to facilitate practices of online harassment. We conclude that, in their gaming practices, male adolescents mediate and reproduce neoliberal values as increasingly shared by society. Regarding their practices of harassment, however, they seem to use digital games as a moratorium that lets them break free from societal restrictions.
Surface plasmon mediated harmonically resonant effects on third harmonic generation from Au and CuS nanoparticle films
Authors: Spear Nathan J. , Yan Yueming , Queen Joshua M. , Singh Mahi R. , Macdonald Janet E. , Haglund Richard F. 
Published: January 2023

Abstract
A growing class of nonlinear materials employ the localized surface plasmonic resonance (LSPR) of nanoparticles to enhance harmonic generation. Material systems containing harmonically coupled metallic and semiconductor plasmonic nanoparticles have been shown to further increase performance. Here, we explore the effect of dual plasmonic interactions in bilayer CuS and Au nanoparticle films on third harmonic generation (THG). Detuning the CuS LSPR away from the excitation frequency changes the dominant upconversion pathway from THG to multiple photon photoluminescence (MPPL). Changing the size of the Au nanoparticle red shifts the LSPR from the second harmonic of the pump frequency and also eliminates the enhancement effect. When both LSPRs satisfy the harmonic condition, simultaneous excitation of CuS-Au nanoparticle films at the resonant frequency of each nanoparticle species enhances the generation of third harmonic light by sum-frequency generation, suggesting that the enhancement of THG in dually plasmonic nanoparticle films is the result of a cascaded nonlinear mechanism. An analytic model of the interaction between the plasmonic nanoparticles due to incoherent dipolar interactions is also presented. Understanding these processes opens a pathway for developing ultrafast, high-efficiency upconversion thin-film devices by clarifying the conditions that efficiently produce third harmonic generation without background MPPL or additional harmonics.
Geotechnical Characterization of Laponite as Transparent Clay Surrogate
Authors: Almikati Abdurrahman , Pierozan Rodrigo Cesar , Sadek Salah , Zornberg Jorge G. 
Published: January 2023

Abstract
The use of so-called “transparent soils” as proxy geotechnical materials has allowed for the nonintrusive observation of a variety of models representing different engineered systems. Laponite is one such soft clay surrogate that has seen increased usage in recent years. However, this material has yet to be subjected to a thorough characterization and quantification of its physical and mechanical properties. The study presented herein followed a systematic approach toward the characterization of Laponite RD colloids from a geotechnical perspective across a wide range of mixes and additive dosages. Rheology tests were conducted to study the variation in apparent viscosity with time and after remixing. These tests identified two sources/types of strength gain: a reversible thixotropic strength gain and an irreversible particle aggregation strength gain. Different mixtures tested in a one-dimensional consolidation oedometer showed that mixes with laponite colloid contents as high as 21 % could be achieved from mixes with an initial colloid content of 11 % by mass. Finally, results from vane shear tests showed that the undrained shear strength increased with: (1) increasing laponite colloid content, (2) decreasing additive dosage, (3) aging time, and (4) increasing temperature. The base geotechnical characteristics and mechanical properties of the clay surrogate as provided in this study are expected to facilitate proper interpretation of the behavior of this surrogate material in geotechnical physical models involving transparent clays.