bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promising Paths and Dead Ends in Evolutionary Theodicy
Authors: Wahlberg Mats 
Published: April 2023

AbstractIn this article, I first reflect on the background of the debate between myself and Eikrem and Søvik and make some clarificatory remarks about the term “Only Way argument”, which figured in the article that started the exchange. I then map areas of agreement and disagreement between us, with an eye to discerning promising and less promising paths forward in the field of evolutionary theodicy. Finally, I respond to Eikrem’s and Søvik’s criticism of my previous arguments about token-goods.
A simulative study on the effect of friction coefficient and angle on failure behaviors of GLARE subjected to low-velocity impact
Authors: You Peiyu , Chen Hui , Li Mingjie , Wu Ye 
Published: April 2023

Abstract
The aim of this paper is to study the effect of friction coefficient and impact angle on the failure behaviors of glass fiber reinforced aluminum laminates (GLARE) under the low-velocity impact (LVI) loading. A methodology is developed in commercial software ABAQUS/Explicit, and its accuracy is verified based on the results of comparison between simulation and experiment. In the simulation, Johnson–Cook flow stress model and surface-based cohesive behavior are carried out to simulate the damage evolution of aluminum alloy layers and delamination at the interface. Further, both the dynamic response history and damage mechanism characterization of these hybrid laminates are presented and compared carefully. Additionally, due to the advantage of simulation, it is accurate and easy to discuss on the evolution of the damage contour consisting of the damage degree of composite and metal layers as well as the interface between them. Finally, the influence rules of friction coefficient and angle on the failure behaviors of GLARE under LVI are drawn clearly.
Stärkung der Spiritualität von Mitarbeitenden des Gesundheitswesens durch Digitale Medien – eine qualitative Untersuchung
Authors: Linseisen Elisabeth , Mächler Ruth , Frick Eckhard 
Published: April 2023

Hintergrund
In den letzten Jahrzehnten hat die Nutzung digitaler Medien (DM) zugenommen, die Covid-19-Pandemie wirkt für die Digitalisierung im Gesundheits- und Sozialwesen als Beschleuniger. Dennoch ist wenig darüber bekannt, wie Mitarbeitende DM in ihren Einrichtungen im Arbeitsalltag einsetzen. Da Spiritual Care (SC) ein wesentlicher Bestandteil dieses Systems ist, sollten förderliche digitale Möglichkeiten bekannt sein.

Forschungsfragen/Ziele: Es sollte untersucht werden, (1) welche DM- und Social-Media-Aktivitäten (SMA) vom Personal im Gesundheitswesen und in Einrichtungen für behinderte oder ältere Menschen genutzt werden, (2) inwieweit die Spiritualität des Personals durch DM unterstützt werden könnte und (3) inwiefern DM/SMA für SC für Arbeitnehmende nützen können.

Methoden: Querschnittsstudie mit 33 halbstrukturierten Telefoninterviews von März bis Mai 2021; die Auswertung erfolgte mittels qualitativer Inhaltsanalyse und deskriptiver Statistiken.

Ergebnisse: (1) Im beruflichen Kontext verwendet etwa die Hälfte der Befragten DM. YouTube wird von 24 Teilnehmenden genutzt, berufsspezifische Apps von 7. (2+3) DM/SMA werden als wertvolle Hilfsmittel für Spiritualität und SC angesehen, die als Unterstützung zu persönlichen Kontakten oder Präsenz dienen können.

Schlussfolgerung: DM/SMA können für Mitarbeitende wertvolle Hilfsmittel für den Umgang mit Spiritualität und SC darstellen, insbesondere in Situationen, in denen ein Kontakt in Präsenz nicht möglich ist.
Electrophysiological Correlates of Proactive Control and Binding Processes during Task Switching in Tourette Syndrome
Authors: Wehmeyer Laura , Schüller Canan Beate , Gruendler Theo O. J. , Huys Daniel , Kuhn Jens , Ullsperger Markus , Visser-Vandewalle Veerle , Andrade Pablo , Baldermann Juan Carlos , Schüller Thomas 
Published: April 2023

AbstractThe occurrence of tics in Tourette syndrome (TS) has often been linked to impaired cognitive control, but empirical findings are still inconclusive. A recent view proposes that tics may be the result of an abnormally strong interrelation between perceptual processes and motor actions, commonly referred to as perception-action binding. The general aim of the present study was to examine proactive control and binding effects in the context of task switching in adult human patients with TS and matched healthy controls. A cued task switching paradigm was employed in 24 patients (18 male, 6 female) and 25 controls while recording electroencephalography (EEG). Residue iteration decomposition (RIDE) was applied to analyze cue-locked proactive cognitive control and target-locked binding processes. Behavioral task switching performance was unaltered in patients with TS. A cue-locked parietal switch positivity, reflecting proactive control processes involved in the reconfiguration of the new task did not differ between groups. Importantly, target-locked fronto-central (N2) and parietal (P3) modulations, reflecting binding processes between perception and action, differed between groups. Underlying neurophysiological processes were best depicted after temporal decomposition of the EEG signal. The present results argue for unaltered proactive control but altered perception-action binding processes in the context of task switching, supporting the view that the integration of perception and action is processed differently in patients TS. Future studies should further investigate the specific conditions under which binding may be altered in TS and the influence of top-down processes, such as proactive control, on bindings.
Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures
Authors: Burrows Dominic R. W. , Diana Giovanni , Pimpel Birgit , Moeller Friederike , Richardson Mark P. , Bassett Dani S. , Meyer Martin P. , Rosch Richard E. 
Published: April 2023

Neuronal activity propagates through the network during seizures, engaging brain dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can relate spatiotemporal activity at the microscale with global network properties. Interestingly, propagating avalanches in healthy networks are indicative of critical dynamics, where the network is organized to a phase transition, which optimizes certain computational properties. Some have hypothesized that the pathologic brain dynamics of epileptic seizures are an emergent property of microscale neuronal networks collectively driving the brain away from criticality. Demonstrating this would provide a unifying mechanism linking microscale spatiotemporal activity with emergent brain dysfunction during seizures. Here, we investigated the effect of drug-induced seizures on critical avalanche dynamics, usingin vivowhole-brain two-photon imaging of GCaMP6s larval zebrafish (males and females) at single neuron resolution. We demonstrate that single neuron activity across the whole brain exhibits a loss of critical statistics during seizures, suggesting that microscale activity collectively drives macroscale dynamics away from criticality. We also construct spiking network models at the scale of the larval zebrafish brain, to demonstrate that only densely connected networks can drive brain-wide seizure dynamics away from criticality. Importantly, such dense networks also disrupt the optimal computational capacities of critical networks, leading to chaotic dynamics, impaired network response properties and sticky states, thus helping to explain functional impairments during seizures. This study bridges the gap between microscale neuronal activity and emergent macroscale dynamics and cognitive dysfunction during seizures.SIGNIFICANCE STATEMENTEpileptic seizures are debilitating and impair normal brain function. It is unclear how the coordinated behavior of neurons collectively impairs brain function during seizures. To investigate this we perform fluorescence microscopy in larval zebrafish, which allows for the recording of whole-brain activity at single-neuron resolution. Using techniques from physics, we show that neuronal activity during seizures drives the brain away from criticality, a regime that enables both high and low activity states, into an inflexible regime that drives high activity states. Importantly, this change is caused by more connections in the network, which we show disrupts the ability of the brain to respond appropriately to its environment. Therefore, we identify key neuronal network mechanisms driving seizures and concurrent cognitive dysfunction.
Two Oscillatory Correlates of Attention Control in the Alpha-Band with Distinct Consequences on Perceptual Gain and Metacognition
Authors: Trajkovic Jelena , Di Gregorio Francesco , Avenanti Alessio , Thut Gregor , Romei Vincenzo 
Published: April 2023

Behavioral consequences and neural underpinnings of visuospatial attention have long been investigated. Classical studies using the Posner paradigm have found that visual perception systematically benefits from the use of a spatially informative cue pointing to the to-be-attended spatial location, compared with a noninformative cue. Lateralized α amplitude modulation during visuospatial attention shifts has been suggested to account for such perceptual gain. However, recent studies on spontaneous fluctuations of prestimulus α amplitude have challenged this notion. These studies showed that spontaneous fluctuations of prestimulus α amplitude were associated with the subjective appreciation of stimulus occurrence, while objective accuracy was instead best predicted by the frequency of α oscillations, with faster prestimulus α frequency accounting for better perceptual performance. Here, in male and female humans, by using an informative cue in anticipation of lateralized stimulus presentation, we found that the predictive cue not only modulates preparatory α amplitude but also α frequency in a retinotopic manner. Behaviorally, the cue significantly impacted subjective performance measures (metacognitive abilities [meta-d′]) and objective performance gain (d′). Importantly, α amplitude directly accounted for confidence levels, with ipsilateral synchronization and contralateral desynchronization coding for high-confidence responses. Crucially, the contralateral α amplitude selectively predicted interindividual differences in metacognitive abilities (meta-d′), thus anticipating decision strategy and not perceptual sensitivity, probably via excitability modulations. Instead, higher perceptual accuracy both within and across participants (d′) was associated with faster contralateral α frequency, likely by implementing higher sampling at the attended location. These findings provide critical new insights into the neural mechanisms of attention control and its perceptual consequences.SIGNIFICANCE STATEMENTPrior knowledge serves the anticipation of sensory input to reduce sensory ambiguity. The growing interest in the neural mechanisms governing the integration of sensory input into our internal representations has highlighted a pivotal role of brain oscillations. Here we show that distinct but interacting oscillatory mechanisms are engaged during attentional deployment: one relying on α amplitude modulations and reflecting internal decision processes, associated with subjective perceptual experience and metacognitive abilities; the other relying on α frequency modulations and enabling mechanistic sampling of the sensory input at the attended location to influence objective performance. These insights are crucial for understanding how we reduce sensory ambiguity to maximize the efficiency of our conscious experience, but also in interpreting the mechanisms of atypical perceptual experiences.
Patent Foramen Ovale-associated Stroke and COVID-19 Vaccination
Authors: Rojko Maja , Cernic Suligoj Natasa , Zorc Metka , Noc Marko 
Published: April 2023

Background: COVID-19 infection has been associated with paradoxical thromboembolism through a patent foramen ovale (PFO) and ischaemic stroke. Such events have not been reported after COVID-19 vaccination. The aim of the present study was to investigate PFO-associated stroke during the mass COVID-19 vaccination in Slovenia. Methods: This prospective study, conducted between 26 December 2020 and 31 March 2022, enrolled consecutive patients (≥18 years) with PFO-associated stroke referred for a percutaneous closure to a single interventional facility in Slovenia. Results: A total of 953,546 people aged between 18 and 70 years received at least one dose of a COVID-19 vaccine approved by the European Medicines Agency. Of the 28 patients presenting with PFO-associated stroke, 12 patients (42.9%) were vaccinated prior to the event, of whom nine were women and three were men, aged between 21 and 70 years. Stroke occurred within 35 days after vaccination in six patients (50%). Clinical presentation included motor dysphasia, paresis, vertigo, ataxia, paraesthesia, headache, diplopia and hemianopia. At hospital discharge, 11 patients (91.6%) had at least one residual ischaemic lesion. Conclusion: A temporal coincidence of COVID-19 vaccination and PFO-associated stroke has been described. A potential cause–effect relationship may only be hypothesised.
COVID–19 és haemostasis
Authors: Pfliegler György , Illés Árpád 
Published: April 2023

Összefoglaló. A szerzők a SARS-CoV-2 vírus okozta járványnak
(COVID–19) a haemostasist érintő, klinikailag fontosabb szempontjait tekintik át
röviden. Felhívják a figyelmet a thromboemboliás szövődmények súlyossága és
gyakorisága mögött levő patomechanizmus jellegzetességére, vagyis a
Virchow-triász három alkotója időben egyszerre történő aktiválódására. A
továbbiakban a kórállapotot és -lefolyást jelző fontosabb haemostasis
laboratóriumi leleteket érintik, majd rátérnek a megelőzés és a kezelés
kérdéseire, mely utóbbiakat a betegség súlyossági csoportokra történő bontásában
tárgyalják, a jelenlegi nemzetközi irányelvekre támaszkodva. Végezetül egy
összefoglaló táblázatban, a nemzetközi ajánlásokon alapuló, de a hazai
szempontokat is figyelembe vevő, általánosan elfogadható antikoagulálási
útmutatót igyekeznek adni, hangsúlyozva a kezelés személyre szabásának
fontosságát.
Summary. In the present paper the most important, clinically
relevant haemostatic effects of SARS-Cov-2 virus infection (COVID-19) is
reviewed and an awareness is raised of the unique pathomechanism which allows a
concurrent activation of each side of the Virchows’ triad responsible for the
aggressivity of thrombotic events in the disease. Subsequently characteristic
haemostatic prognostic and staging laboratory results are discussed followed by
a brief survey of anticoagulant prophylaxis and therapy in the different
severity stages of the disease. Finally a brief guidance is given based on
various international guidelines with an adoption of current Hungarian situation
and emphasizing the importance of personalized decisions.
Új terápiás lehetőség a cutan T-sejtes lymphomák kezelésében: a mogamulizumab
Authors: Miltényi Zsófia 
Published: April 2023

Összefoglaló. A cutan T-sejtes lymphomák a non-Hodgkin lymphomák
heterogén csoportját képviselik. A leggyakoribb altípus a mycosis fungoides,
melynek korai stádiumában az 5 éves betegségspecifikus túlélés 90% körüli, az
előrehaladott stádiumokban azonban csak 30–50%. Az agresszív formák rossz
prognózisúak, nagy betegszámú, randomizált klinikai vizsgálatok hiányában
egységes, hatékony kezelési módszerrel nem rendelkezünk. A szisztémás
lymphoproliferatív betegségek kezelésében egyre inkább előtérbe kerülnek a
célzott terápiás lehetőségek, melyek a cután lymphomákban is hatékonyak
lehetnek. Ezek közül az anti CCR4 antitesttel, a mogamulizumabbal már vannak
kedvező tapasztalatok. Fázis 3 vizsgálat során 28%-os teljes válaszarányt és 7,7
hónapos medián túlélést igazoltak relabáló vagy refrakter mycosis fungoidesben
vagy Sézary-szindrómában szenvedő betegeknél. A leggyakoribb mellékhatások az
infúziós reakciók, a kiütés, hasmenés és krónikus fáradtság voltak. A vizsgálat
eredménye alapján a mogamulizumabot az Európai Gyógyszerügynökség is befogadta
ezen betegcsoport kezelésére, remélhetőleg nemsokára hazánkban is hozzáférhető
lesz.
Summary. Cutaneous T-cell lymphomas represent a heterogeneous group
of non-Hodgkin’s lymphomas. The most common subtype is mycosis fungoides, with
an early 5-year disease-specific survival of around 90%, but only 30–50% in the
advanced stages. Aggressive forms have poor prognosis in the absence of large,
randomized clinical trials we do not have a uniform, effective treatment method.
In the treatment of systemic lymphoproliferative diseases, targeted therapeutic
options are emerging that may be effective in cutaneous lymphomas. Of these, the
anti CCR4 antibody was mogamulizumab there are already positive experiences. In
a phase 3 study, a 28% overall response rate and a median survival of 7.7 months
were demonstrated in patients with relapsed or refractory mycosis fungoides or
Sezary’s syndrome. The most common side effects were infusion reactions, rash,
diarrhea, and chronic fatigue. Based on the results of the study, mogamulizumab
has also been accepted by the European Medicines Agency for the treatment of
this group of patients and will hopefully be available in Hungary soon.
Phase and properties prediction of Al–Ag binary system using thermo-calc
Authors: Ben Festus , Olubambi P. A. 
Published: April 2023

AbstractThe temperature phase diagram stability and physical properties of a binary Silver–Aluminium (Al–Ag) alloy system have been calculated using Thermo-Calc 2021b software at a temperature range of 250–1300 K. Six single-solid phases other than the liquid phase, elemental Ag (fcc_Ag), elemental Al (fcc_Al), hcp_A3, cub_A13, and bcc_Ag were obtained from the equilibrium calculation. Ten regions of the double phase were obtained and evaluated. Three intermediate phases were also obtained from the phase diagram with five invariant reactions, namely one eutectic reaction (at 840.00 K), two peritectic reactions (at 1051.22 K and 1003.18 K), and two peritectoid reactions (at 730.58 K and 881.40 K) were equally found. Sixteen regions other than elemental Ag and Al at 0, and 100, respectively, were obtained. Maximum solid solubility obtained was 5.60 Al mass percent at 730. 58 K for Al in Ag and 58.17 Ag mass percent at 840.00 K for Ag in Al. From the temperature–composition phase diagram, the melting point for pure silver and aluminium were equally inferred as 1234.96 K and 933.50 K, respectively, which agrees with experimental standards. These results play a significant role in the processing of Al–Ag alloy for different industrial-related applications.

Graphical abstract
The domestic wastewater treatment capacity of Spirulina platensis SP4 and the application of the treated wastewater in stimulating rice germination
Authors: Thi Kieu Oanh Nguyen , Thi Thuy Duong , Thi Oanh Doan , Thi Nguyet Vu , Van Nam Nguyen 
Published: April 2023

Many scientists are interested in microalgae and cyanobacteria because of their richness in high-value bioactive metabolites (proteins, lipids, vitamins, plant growth regulators, and others). Microalgae and cyanobacteria can be used to produce valuable commodities such as dietary supplements, biofuel, animal feed, and agricultural fertilizer, etc. To improve the economic feasibility of the cyanobacterial product recovery process, it is possible to utilize domestic wastewater as a source of nutrients for their growth. This research focuses on assessing the ability of domestic wastewater treatment and treated domestic wastewater utilization to stimulate BC15 rice-grain sprouting by cyanobacteria Spirulina platensis SP4. Research results showed that S. platensis SP4 grown best in domestic wastewater at the initial density of 0.3 and the wastewater concentration of 100%. The incubation of S. platensis was performed in the laboratory under the condition of 16.8 g/L NaHCO3; aeration during 8 h/day; light: dark cycle of 8:16; light intensity of 5000 lux. Under these conditions S. platensis SP4 could treat N-NH4+, T-N, P-PO43-, T-P and COD well with the treatment efficiency of 96.37, 49.71, 67.05, 65.88 and 95.53%, respectively. The addition of treated domestic wastewater by S. platensis SP4 to BC15 rice grains stimulated the grouting by 99.54 ± 1.25%, which was 1.54 times higher than using the tap water and gave a germination efficiency equivalent to that of the experiments with adding cyanobacteria in standard medium with or without L-tryptophan addition for 48 h. The obtained research results have elucidated the feasibility of employing cyanobacteria in residential wastewater treatment as well as the reuse of treated wastewater for plant development.
Isolation, selection and evaluation of α-glucosidase inhibitory activity from endophytic Streptomyces sp. isolated from Citrus myrtifolia cultivar in Hoa Binh, Vietnam
Authors: Thi Trung Nguyen , Thi Thao Nguyen , Hong Thao Phan Thi , Thanh Tuan Tran , Duy Nam Pham , Thanh Hoang Le , Tuyen Do Thi 
Published: April 2023

Cao Phong orange (Citrus sinensis Lour) was grown in Cao Phong district, Hoa Binh province. Citrus sinensis is Vietnam’s most valued commercial fruit. In this study, 30 microorganim strains were isolated from the samples of root, stem, and leaf of Cao Phong orange. The ratio of endophytic actinomycetes was found in different parts of the plant: root, stem, and leaf was 37%, 40%, and 23%, respectively. The isolating HBC6-2 was selected because of its high output of α-glucosidase inhibitors from 6 different strains. Morphological, physiological, and biochemical characterization showed that HBC6-2 strain belongs to the Streptomyces sp. The 16S rRNA sequence of HBC6-2 indicated 99% identity to the corresponding sequence of Streptomyces costaricanus, and was registered on GenBank with the code MT 453944.1.
Streptomyces costaricanus EBL.HB6 was able to produce melanin yelow pigment, and its aerial and substrate mycelia have brown and yellow-grey pigment on ISP2, ISP3, ISP4, and ISP5 cultivating medium, respectively. The optimal pH range was from 5-10 and temperature from 15-40°C and exhibited salt tolerance up to 3% and utilized the carbon sources such as fructose, xylose, arabinose, cellulose, and rhamnose. In the following investigation, Streptomyces costaricanus EBL.HB6 displayed the highest α-glucosidase inhibitory activity by 68.98% among Streptomyces sp. strains