bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODELLING OF CO-AXIAL AND TRI-AXIAL MILLI-FLUIDIC DEVICES FOR CO-EXTRUSION OF SEMI-SOLID SOLIDS
Authors: Al-Sharai Abdo Ali , Soon Chin Fhong , See Chan Hwang , Yee See Khee , Tee Kian Sek , Abdul Wahab Mohammed 
Published: June 2023

With the use of a milli-fluidics device, it is possible to manipulate small amounts of fluid in the millimeter range with pinpoint accuracy. The milli-fluidics are currently lacking in studies of the relationship between fluid viscosity, output velocity and output pressure. Thus, this study examines the effects of viscosity on fluid dynamics in the co-axial and tri-axial milli-fluidics. This geometry of the co-axial and tri-axial milli-fluidics consist of single outlet, two inlets and three inlets, respectively. The tri-axial milli-fluidics is 46 mm long and 11.31 mm wide, while, the coaxial milli-fluidic is 64.73 mm long and 9.2 mm wide. The co-axial milli-fluidics constituted of 775 domain elements and 147 boundary elements, while, the tri-axial milli-fluidics mesh constituted of 1518 domain elements and 178 boundary elements. Laminar flow was observed for the flow of the materials through the channels. When the dynamic viscosity approaches 5 mPa.s, the simulation reveals that the flow rate is inversely proportional to the dynamic viscosity for co-axial milli-fluidics. It was difficult to combine fluids with different viscosities with small volume of water in a narrow boundary, thus the parallel flow of material was observed. When using the one outlet channel for the tri-axial milli-fluidics, the assemble pressure at the three inlets was decreased compared with co-axial milli-fluidic. Even when the dynamic velocity of the fluid at outlet 1 increased, its velocity remained consistent. An extruder using tri-axial milli-fluidics can be used if the interfacial tension for intake 1 is higher than for inlet 2 and the dynamic viscosity of fluid 1 is above 2 mPas, according to the volumetric fraction model. The tri-axial milli-fluidic was found to be suitable for producing cladding of material with the balanced pressure from the two side channels.
Extensions of Veech groups I: A hyperbolic action
Authors: Dowdall Spencer , Durham Matthew G. , Leininger Christopher J. , Sisto Alessandro 
Published: June 2023

AbstractGiven a lattice Veech group in the mapping class group of a closed surface , this paper investigates the geometry of , the associated ‐extension group. We prove that is the fundamental group of a bundle with a singular Euclidean‐by‐hyperbolic geometry. Our main result is that collapsing “obvious” product regions of the universal cover produces an action of on a hyperbolic space, retaining most of the geometry of . This action is a key ingredient in the sequel where we show that is hierarchically hyperbolic and quasi‐isometrically rigid.
“I Can See Your Password”: A Case Study About Cybersecurity Risks in Mid-Air Interactions of Mixed Reality-Based Smart Manufacturing Applications
Authors: Yang Wenhao , Dengxiong Xiwen , Wang Xueting , Hu Yidan , Zhang Yunbo 
Published: June 2023

Abstract
This paper aims to present a potential cybersecurity risk existing in mixed reality (MR)-based smart manufacturing applications that decipher digital passwords through a single RGB camera to capture the user’s mid-air gestures. We first created a test bed, which is an MR-based smart factory management system consisting of mid-air gesture-based user interfaces (UIs) on a video see-through MR head-mounted display. To interact with UIs and input information, the user’s hand movements and gestures are tracked by the MR system. We setup the experiment to be the estimation of the password input by users through mid-air hand gestures on a virtual numeric keypad. To achieve this goal, we developed a lightweight machine learning-based hand position tracking and gesture recognition method. This method takes either video streaming or recorded video clips (taken by a single RGB camera in front of the user) as input, where the videos record the users’ hand movements and gestures but not the virtual UIs. With the assumption of the known size, position, and layout of the keypad, the machine learning method estimates the password through hand gesture recognition and finger position detection. The evaluation result indicates the effectiveness of the proposed method, with a high accuracy of 97.03%, 94.06%, and 83.83% for 2-digit, 4-digit, and 6-digit passwords, respectively, using real-time video streaming as input with known length condition. Under the unknown length condition, the proposed method reaches 85.50%, 76.15%, and 77.89% accuracy for 2-digit, 4-digit, and 6-digit passwords, respectively.
Adherence to a Ketogenic Low-Carbohydrate, High-Fat Diet Is Associated With Diminished Training Quality in Elite Racewalkers
Authors: McKay Alannah K.A. , Ross Megan L.R. , Tee Nicolin , Sharma Avish P. , Leckey Jill J. , Burke Louise M. 
Published: June 2023

Purpose:To examine the effects of a high-carbohydrate diet (HCHO), periodized-carbohydrate (CHO) diet (PCHO), and ketogenic low-CHO high-fat diet (LCHF) on training capacity.Methods:Elite male racewalkers completed 3 weeks of periodic training while adhering to their dietary intervention. Twenty-nine data sets were collected from 21 athletes. Each week, 6 mandatory training sessions were completed, with additional sessions performed at the athlete’s discretion. Mandatory sessions included an interval session (10 × 1-km efforts on a 6-min cycle), tempo session (14 km with a 450-m elevation gain), 2 long walks (25–40 km), and 2 easy walks (8–12 km) where “sleep-low” and “train-low” dietary strategies were employed for PCHO. Racewalking speed, heart rate, rating of perceived exhaustion, and blood metabolites were collected around key sessions.Results:LCHF covered less total distance than HCHO and PCHO (P < .001); however, no differences in training load between groups were evident (P = .285). During the interval sessions, walking speed was slower in LCHF (P = .001), equating to a 2.8% and 5.6% faster speed in HCHO and PCHO, respectively. LCHF was also 3.2% slower in completing the tempo session than HCHO and PCHO (P = .001). Heart rate was higher (P = .002) and lactate concentrations were lower (P < .001) in LCHF compared to other groups, despite slower walking speeds during the interval session. No between-groups differences in rating of perceived exhaustion were evident (P = .077).Conclusion:Athletes adhering to an LCHF diet showed impaired training capacity relative to their high-CHO-supported counterparts, completing lower training volumes at slower speeds, with higher heart rates.
Performance and symmetry measures during vertical jump testing at return to sport after ACL reconstruction
Authors: Kotsifaki Roula , Sideris Vasileios , King Enda , Bahr Roald , Whiteley Rod 
Published: June 2023

ObjectiveVertical jump tests are more sensitive in revealing asymmetries in performance metrics at the time of return to sport after anterior cruciate ligament (ACL) reconstruction (ACLR) than horizontal hop tests. However, it remains unclear which vertical tests (bilateral or unilateral) and which metrics (kinetics or performance) are most effective in informing the rehabilitation status and readiness for return to sport. We aimed to investigate the status of athletes during vertical jump testing at return to sport after ACLR.MethodsA dual force platform system was used to evaluate jumping performance of 126 recreational and professional athletes at the time of return to sport after ACLR, as well as 532 healthy control participants. Performance and kinetic metrics were collected during four jump tests: double-leg countermovement jump, single-leg countermovement jump, double-leg 30 cm drop jump and single-leg 15 cm drop jump. Between-limb and between-group differences were explored using mixed models analyses.ResultsAt the time of return to sport after ACLR, athletes still presented significant differences favouring the uninvolved side, particularly in the symmetry of the concentric impulse (p<0.001) in all jumps compared with the control group. Peak landing force asymmetry was greater in the ACLR group than the controls during the countermovement (p<0.001, MD=−11.6; 95% CI –15.4 to –7.9) and the double-leg drop jump (p=0.023, MD=−8.9; 95% CI –14.9 to –2.8). The eccentric impulse asymmetry was significantly greater (p=0.018, MD=−3.8; 95% CI −5.8 to –1.7) in the ACLR group during the single-leg drop jump only. Jump height was significantly lower (p<0001) in the ACLR group compared with controls in all tests except the double-leg drop jump.ConclusionAt the time of return to sport after ACLR, despite passing the traditional discharge criteria, athletes remained asymmetrical during all vertical jump tests, in the concentric (push-off) phase, during landing from bilateral jumps and for most performance metrics. Clinicians should aim to restore not only symmetry in ground reaction forces but also absolute performance metrics such as jump height, reactive strength index and contact times, to potentially reduce injury risk and improve overall athletic performance.
ALL-RIC trial protocol: a comparison of reduced dose total body irradiation (TBI) and cyclophosphamide with fludarabine and melphalan reduced intensity conditioning in adults with acute lymphoblastic leukaemia (ALL) in complete remission
Authors: Marks David I , Castleton Anna , Olavarria Eduardo , Gilleece Maria , Fielding Adele , Mikhaeel George , Beasley Matthew , Diez Patricia , Jackson Aimee , Hodgkinson Andrea , Elhanied Mohamed , Chakraverty Ronjon 
Published: June 2023

IntroductionThe usage of a T-cell depleted, reduced intensity conditioning (RIC) approach to haematopoietic cell transplantation (HCT) in adult patients with acute lymphoblastic leukaemia (ALL) over 40 years of age and in first complete remission (CR) has resulted in encouraging rates of event-free and overall survival in a population of adults with high risk disease. However, relapse rates remain high—with disease progression being the major cause of treatment failure. Using different, more powerful conditioning approaches is the logical next step in examining the role of RIC allogeneic HCT in adult ALL.Methods and analysisThe ALL-RIC trial is a two-arm, phase II, multicentre, randomised clinical trial in adult patients with ALL in first or second CR, who are undergoing allogeneic HCT. Comparison of a novel RIC transplant conditioning regimen using reduced-dose total body irradiation (TBI), cyclophosphamide and alemtuzumab, is made against a standardised RIC approach using fludarabine, melphalan and alemtuzumab. The primary outcome of the study is disease-free survival at 3 years, defined as time from randomisation to the first of either relapse or death from any cause. Patients who are still alive and progression-free at the end of the trial will be censored at their last date known to be alive. Secondary outcomes include overall survival and non-relapse mortality.Ethics and disseminationThe protocol was approved by the East Midlands—Leicester Central Research Ethics committee (18/EM/0112). Initial approval was received on 12 June 2018. Current protocol version (V.6.0) approval obtained on 18 November 2019. The Medicines and Healthcare products Regulatory Agency (MHRA) also approved all protocol versions. The results of this trial will be disseminated through national and international presentations and peer-reviewed publications.Trial registration numberEudraCT Number: 2017-004800-23.ISRCTN99927695.
Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden: results of a cross-sectional study in Estonia
Authors: Pärna Kersti , Nygård Mari , Tisler Anna , Toompere Karolin , Naaber Paul , Ratnik Kaspar , Ķīvīte Urtāne Anda , Zodzika Jana , Stankūnas Mindaugas , Baltzer Nicholas , Uusküla Anneli 
Published: June 2023

ObjectivesTo describe age-specific and type-specific carcinogenic human papillomavirus (HPV) prevalence prior to large-scale effect of HPV vaccines in Estonia and to analyse the risk factors associated with carcinogenic HPV.DesignCross-sectional study using self-administered questionnaire and self-collected vaginal swabs for detection of HPV infection.SettingEstonian Biobank database.ParticipantsStratified random sample of women aged 30–33, 57–60 and 67–70 years living in one of the three largest counties in Estonia. Of 3065 women approached, 1347 (43.9%) returned questionnaires and specimens for HPV DNA detection.Outcome measuresHPV prevalence and fully adjusted ORs with 95% CIs for risk factors.ResultsHPV prevalence was highest among women aged 30–33 years (18.7%; 95% CI 15.8 to 21.9) followed by those aged 67–70 years (16.7%; 95% CI 12.4 to 22.0) and 57–60 years (10.2%; 95% CI 7.8 to 13.3). HPV16 and HPV56 were the most common among women aged 30–33 years (both 4.0%; 95% CI 2.7 to 5.9), and HPV68 was the most common among women aged 57–60 years (2.8%; 95% CI 1.5 to 4.7) and 67–70 years (6.4%; 95% CI 3.6 to 10.4). Vaccination with nonavalent vaccine would have halved the carcinogenic HPV prevalence among women aged 30–33 years. The odds of infection with carcinogenic HPV were higher among women with six or more sexual partners among younger (OR 2.99; 95% CI 1.54 to 5.81) and older (OR 3.80; 95% CI 1.25 to 11.55) women and lower (OR 0.35; 95% CI 0.17 to 0.72) among younger married women.ConclusionsThis study demonstrated U-shaped age-specific genotype profile of carcinogenic HPV prevalence, indicating that public health providers should focus on developing exit strategies for the cervical cancer screening programme in Estonia with a possible extension of HPV testing beyond the current screening age of 65 years. Generalisability of the findings of this study may be affected by the low response rate.
Shared characteristics of intervention techniques for oral vocabulary and speech comprehensibility in preschool children with co-occurring features of developmental language disorder and a phonological speech sound disorder: protocol for a systematic review with narrative synthesis
Authors: Rodgers Lucy , Botting Nicola , Cartwright Martin , Harding Sam , Herman Rosalind 
Published: June 2023

IntroductionEvidence suggests that over one-third of young children with developmental language disorder (DLD) or speech sound disorder (SSD) have co-occurring features of both. A co-occurring DLD and SSD profile is associated with negative long-term outcomes relating to communication, literacy and emotional well-being. However, the best treatment approach for young children with this profile is not understood. The aim of the proposed review is to identify intervention techniques for both DLD and SSD, along with their shared characteristics. The findings will then be analysed in the context of relevant theory. This will inform the content for a new or adapted intervention for these children.Methods and analysisThis search will build on a previous systematic review by Roulstoneet al(2015) but with a specific focus on oral vocabulary (DLD outcome) and speech comprehensibility (SSD outcome). These outcomes were identified by parents and speech and language therapists within the prestudy stakeholder engagement work. The following databases will be searched for articles from January 2012 onwards: Ovid Emcare, MEDLINE Complete, CINAHL, APA PsycINFO, Communication Source and ERIC. Two reviewers will independently perform the title/abstract screening and the full-text screening with the exclusion criteria document being revised in an iterative process. Articles written in languages other than English will be excluded. Data will be extracted regarding key participant and intervention criteria, including technique dosage and delivery details. This information will then be pooled into a structured narrative synthesis.Ethics and disseminationEthical approval is not needed for a systematic review protocol. Dissemination of findings will be through peer-reviewed publications, social media, and project steering group networks.PROSPERO registration numberCRD4202237393.
Paving the way for solutions improving access to kidney transplantation: a qualitative study from a multistakeholder perspective
Authors: Merweland Ruben van , Busschbach Jan J V , van de Wetering Jacqueline , Ismail Sohal 
Published: June 2023

ObjectivesThe aim of this study was to obtain an in-depth perspective from stakeholders involved in access to kidney transplantation to pave the way for solutions in improving access to kidney transplantation. This study qualitatively explored factors influencing optimal access to kidney transplantation from a broad stakeholder perspective.DesignA qualitative study was performed using semistructured interviews both in focus groups and with individual participants. All interviews were recorded, transcribed and coded according to the principles of grounded theory.SettingParticipants were healthcare providers (geographically spread), patients and (former living) kidney donors, policy-makers and insurers.ParticipantsStakeholders (N=87) were interviewed regarding their perceptions, opinions and attitudes regarding access to kidney transplantation.ResultsThe problems identified by stakeholders within the domains—policy, medical, psychological, social and economic—were acknowledged by all respondents. According to respondents, more efforts should be made to make healthcare providers and patients aware of the clinical guideline for kidney transplantation. The same opinion applied to differences in medical inclusion criteria used in the different transplantation centres. Stakeholders saw room for improvement based on psychological and social themes, especially regarding the provision of information. Many stakeholders described the need to rethink the current economic model to improve access to kidney transplantation. This discussion led to a definition of the most urgent problems for which, according to the respondents, a solution must be sought to optimise access to kidney transplantation.ConclusionsStakeholders indicated a high sense of urgency to solve barriers in patient access to kidney transplantation. Moreover, it appears that some barriers are quite straightforward to overcome; according to stakeholders, it is striking that this process has not yet been overcome. Stakeholders involved in kidney transplantation have provided directions for future solutions, and now it is possible to search for solutions with them.
Pragmatic multicentre stepped-wedge cluster randomised trial to investigate the effectiveness of community-based falls prevention programme for older adults with falls risk in Singapore: a protocol paper
Authors: Tan Pey June , Ginting Mimaika Luluina , Lim Zoe Zon Be , Balachandar Nivedha , Sultana Rehena , Kadir Mumtaz Mohamed , Xu Tianma , Ismail Noor Hafizah , Yap Joyce Kwee Yong , Wong Sweet Fun , Yoong Joanne , Matchar David Bruce , Hill Keith , Wong Chek Hooi 
Published: June 2023

IntroductionFalls are an important public health issue with consequences that include injuries, quality of life reduction and high healthcare costs. Studies show that falls prevention strategies are effective in reducing falls rate among community-dwelling older adults. However, the evaluation for effectiveness was usually done in a controlled setting with homogeneous population, and thus may not be generalisable to a wider population. This study aims to evaluate the impact of community falls prevention programmes with group-based strength and balance exercises, on falls risk and health outcomes for older adults with falls risk in Singapore.Methods and analysisThis is a pragmatic closed cohort stepped-wedge cluster randomised trial design study, which involves sequential crossover of clusters from the waitlist control condition to the intervention condition, with the sequence of crossover randomly determined. The intervention will be sequentially rolled out to 12 clusters (a minimum of 5 participants/cluster), over 6 time periods with 8-week intervals in Central and North regions of Singapore. The primary analysis will be conducted under the intention-to-treat principle. A general linear mixed model or generalised estimating equation analysis appropriate for a multilevel longitudinal study incorporating an appropriate error distribution and link function will be used. Markov model will be developed to estimate the incremental cost per quality-adjusted life years and incremental cost per fall prevented from the implementation of falls prevention strategies from a societal perspective. Conditional on there being clinically relevant differences in short-term outcomes, we will implement simulation modelling to project the long-term divergence in trajectories for outcomes and costs using the Markov model.Ethics and disseminationEthics approval has been obtained. Results will be disseminated in publications and other relevant platforms.Trial registration numberNCT04788251.
Study protocol: pneumonia and inhaled corticosteroid treatment patterns in chronic obstructive pulmonary disease – a cohort study using sequence analysis (PICCS)
Authors: Klitgaard Allan , Ibsen Rikke , Hilberg Ole , Løkke Anders 
Published: June 2023

IntroductionTreatment with inhaled corticosteroids (ICS) is a widely used treatment in chronic obstructive pulmonary disease. The main effects include a reduction in the number of exacerbations and, for some patients, an increase in expected mortality. Unfortunately, the treatment is also linked to an increased risk of pneumonia, and very little is known about which patients experience this increased risk. There is a need for identification of patient characteristics associated with increased risk of pneumonia and treatment with ICS.Methods and analysisThis is a register-based cohort study that uses the nationwide Danish registers. Data from several registers in the years 2008–2018 will be merged on an individual level using the personal identification numbers that are unique to every citizen in Denmark. Clusters based on pneumonia incidence and ICS treatment patterns will be explored with a sequence analysis in a 3-year follow-up period.Ethics and disseminationThis is a register-based study and research ethics approval is not required according to Danish Law and National Ethics Committee Guidelines. The results will be submitted to peer-reviewed journals and reported at appropriate national and international meetings.
Outcomes in patients with large vessel occlusion strokes undergoing mechanical thrombectomy with concurrent COVID-19: a nationwide retrospective analysis
Authors: Ramsay Ian A , Fountain Hayes , Elarjani Turki , Govindarajan Vaidya , Silva Michael , Abdelsalam Ahmed , Burks Joshua D , Starke Robert M , Luther Evan 
Published: June 2023

BackgroundPreliminary studies show that patients with large vessel occlusion (LVO) acute ischemic strokes have worse outcomes with concurrent COVID-19 infection. We investigated the outcomes for patients with LVO strokes undergoing mechanical thrombectomy (MT) with concurrent COVID-19 infection.MethodsThe National Inpatient Database (NIS) was used for our analysis. Patients in the year 2020 with an ICD-10 diagnosis code for acute ischemic stroke and procedural code for MT were included with and without COVID-19. Odds ratios (OR) were calculated using a logistic regression model with age, sex, stroke location, Elixhauser comorbidity score, and other patient variables deemed clinically relevant as covariates.ResultsPatients in the COVID-19 group were younger (64.3±14.4 vs 69.4±14.5 years, P<0.001), had a higher rate of inpatient mortality (22.4% vs 10.1%, P<0.001), and a longer length of stay (10 vs 6 days, P<0.001). Patients with COVID-19 had higher odds of death (OR 2.78, 95% CI 2.11 to 3.65) and lower odds of a routine discharge (OR 0.65, 95% CI 0.48 to 0.89). There was no difference in the odds of subsequent stroke and cerebral hemorrhage, but patients with COVID-19 had statistically significantly higher odds of respiratory failure, pulmonary embolism, deep vein thrombosis, myocardial infarction, acute kidney injury, and sepsis.ConclusionsPatients with LVOs undergoing MT within the 2020 NIS database had worse outcomes when co-diagnosed with COVID-19, likely due to non-neurological manifestations of COVID-19.