bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum anti-Müllerian hormone levels are associated with perinatal outcomes in women undergoing IVF/ICSI: A multicenter retrospective cohort study
Authors: He Yi-Chen , Su Kai-Zhen , Cai Jie , Meng Qing-Xia , Wu Yan-Ting , Huang He-Feng 
Published: February 2023

IntroductionAnti-Müllerian hormone (AMH) level has long been considered as a serum biomarker of ovarian reserve clinically, while emerging data suggest that serum AMH level may also predict pregnancy outcomes. However, whether pregestational serum AMH levels are related to perinatal outcomes among women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles is unknown.ObjectiveTo explore the association between different AMH levels and perinatal outcomes in women with live births in IVF/ICSI.MethodsThis multicenter retrospective cohort study was conducted among three different provinces in China, from January 2014 to October 2019. A total of 13,763 IVF/ICSI cycles with 5657 live-delivery pregnant women and 6797 newborns were recruited. Participants were categorized into three groups according to the &lt;25th (low), 25 to 75th (average), and &gt;75th (high) percentile of serum AMH concentration. Perinatal outcomes were compared among groups. Subgroup analyses were conducted based on the number of live births.ResultsAmong women with singleton deliveries, low and high AMH levels increased the risk of intrahepatic cholestasis of pregnancy (ICP) (aOR1 = 6.02, 95%CI: 2.10-17.22; aOR2 = 3.65, 95%CI:1.32-10.08) and decreased the risk of macrosomia (aOR1 = 0.65, 95%CI:0.48-0.89; aOR2 = 0.72, 95%CI:0.57-0.96), while low AMH reduced the risk of large for gestational age (LGA, aOR=0.74, 95%CI:0.59-0.93) and premature rupture of membrane (PROM, aOR=0.50, 95%CI:0.31-0.79)compared with the average AMH group. In women with multiple deliveries, high AMH levels increased the risks of gestational diabetes mellitus (GDM, aOR=2.40, 95%CI:1.48-3.91) and pregnancy-induced hypertension (PIH, aOR=2.26, 95%CI:1.20-4.22) compared with the average AMH group, while low AMH levels increased the risk of ICP (aOR=14.83, 95%CI:1.92-54.30). However, there was no evidence of differences in preterm birth, congenital anomaly, and other perinatal outcomes among the three groups in both singleton and multiple deliveries.ConclusionsAbnormal AMH levels increased the risk of ICP regardless of the number of live births for women undergoing IVF/ICSI, while high AMH levels increased the risks of GDM and PIH in multiple deliveries. However, serum AMH levels were not associated with adverse neonatal outcomes in IVF/ICSI. The underlying mechanism warrants further investigation.
Evaluating the influence of sleep quality and quantity on glycemic control in adults with type 1 diabetes
Authors: Botella-Serrano Marta , Velasco Jose Manuel , Sánchez-Sánchez Almudena , Garnica Oscar , Hidalgo J. Ignacio 
Published: February 2023

BackgroundSleep quality disturbances are frequent in adults with type 1 diabetes. However, the possible influence of sleep problems on glycemic variability has yet to be studied in depth. This study aims to assess the influence of sleep quality on glycemic control.Materials and methodsAn observational study of 25 adults with type 1 diabetes, with simultaneous recording, for 14 days, of continuous glucose monitoring (Abbott FreeStyle Libre system) and a sleep study by wrist actigraphy (Fitbit Ionic device). The study analyzes, using artificial intelligence techniques, the relationship between the quality and structure of sleep with time in normo-, hypo-, and hyperglycemia ranges and with glycemic variability. The patients were also studied as a group, comparing patients with good and poor sleep quality.ResultsA total of 243 days/nights were analyzed, of which 77% (n = 189) were categorized as poor quality and 33% (n = 54) as good quality. Linear regression methods were used to find a correlation (r =0.8) between the variability of sleep efficiency and the variability of mean blood glucose. With clustering techniques, patients were grouped according to their sleep structure (characterizing this structure by the number of transitions between the different sleep phases). These clusters showed a relationship between time in range and sleep structure.ConclusionsThis study suggests that poor sleep quality is associated with lower time in range and greater glycemic variability, so improving sleep quality in patients with type 1 diabetes could improve their glycemic control.
Variation in microbial CAZyme families across degradation severity in a steppe grassland in northern China
Authors: Zhang Qian , Xu Xiaoqing , Duan Junguang , Koide Roger T. , Xu Lei , Chu Jianmin 
Published: February 2023

Little is known about the effects of grassland degradation on the carbohydrate-active enzyme (CAZYme) genes responsible for C cycling. Here we used a metagenomic approach to reveal variation in abundance and composition of CAZyme genes in grassland experiencing a range of degradation severity (i.e., non-, light, moderately, and severely degraded) in two soil layers (0–10 cm, 10–20 cm) in a steppe grassland in northern China. We observed a higher CAZyme abundance in severely degraded grassland compared with the other three degradation severities. Glycoside hydrolase (GH) and glycosyltransferase (GT) were identified as the most abundant gene families. The Mantel test and variation partitioning suggested an interactive effect of degradation severity and soil depth with respect to CAZyme gene composition. Structural equation modeling indicated that total soil carbon, microbial biomass carbon and organic carbon were the three soil characteristics most important to CAZyme abundance, which suggests an interaction between degradation and soil carbon fractions in determining CAZyme gene composition. Both above- and below-ground factors linked to soil organic matter play a central role in determining the abundance of CAZyme gene families.
A response of biomass and nutrient allocation to the combined effects of soil nutrient, arbuscular mycorrhizal, and root-knot nematode in cherry tomato
Authors: Wang Lei , Chen Xin , Yan Xingfu , Wang Congli , Guan Pingting , Tang Zhanhui 
Published: February 2023

IntroductionThe biomass and nutrient allocation strategies in plants are fundamental for predicting carbon storage and mineral and nutrient cycles in terrestrial ecosystems. However, our knowledge regarding the effects of multiple environmental factors on biomass and nutrient allocation remains limited.MethodsHere we manipulated soil composition (three levels), arbuscular mycorrhizal fungi inoculation (AMF, five levels), and root-knot nematode inoculation (RKN, two levels) using random block design to reveal the effects of these factors on biomass and nutrient allocation strategies of cherry tomato.Results and DiscussionOur results showed that biomass and nutrient allocation were affected by soil composition, AMF and RKN individually or interactively. The biomass and nutrient allocation in cherry tomato shows different adaptation strategies responded to the joint action of three factors. The reduction of soil nutrients increased belowground biomass allocation, and aboveground nitrogen and phosphorus concentration. AMF colonization increased aboveground biomass allocation and reproductive investment and promoted aboveground nitrogen and phosphorus inputs. Cherry tomato can mitigate the stress of RKN infection by investing more biomass and nutrients into belowground organs. Our study showed that plants can adjust their survival strategies by changing biomass and nutrient allocation to adapt to variation in soil abiotic and biotic factors. These findings contribute to our understanding of the adaptive processes of plant biomass and nutrient allocation strategies under multiple environmental factors.
Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018
Authors: Di Xingpeng , Liu Shaozhuang , Xiang Liyuan , Jin Xi 
Published: February 2023

BackgroundThe incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. The systemic immune-inflammatory index (SII) was initially identified as a prognosis of multiple diseases. We performed an updated analysis on the impact of SII on kidney stones.MethodsThis compensatory cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey 2007-2018. Univariate and multivariate logistic regression analyses were performed to investigate the association between SII and kidney stones.ResultsOf the 22220 participants, the mean (SD) age was 49.45 ± 17.36 years old, with a 9.87% incidence rate of kidney stones. A fully adjusted model showed that SII higher than 330 x 109/L was parallel associated with kidney stones (Odds ratio [OR] = 1.282, 95% Confidence interval [CI] = 1.023 to 1.608, P = 0.034) in adults aged 20-50. However, no difference was found in the elderly subgroup. Multiple imputation analyses confirmed the robustness of our results.ConclusionsOur findings suggested SII was positively associated with a high risk of kidney stones in US adults aged less than 50. The outcome compensated for previous studies that still needed more large-scale prospective cohorts for validation.
Clinical significance and related factors of rectal hyposensitivity in patients with functional defecation disorder
Authors: Jiang Ya , Wang Yan , Wang Meifeng , Lin Lin , Tang Yurong 
Published: February 2023

BackgroundRectal hyposensitivity (RH) is not uncommon in patients with functional defecation disorder (FDD). FDD patients with RH are usually unsatisfied with their treatment.AimsThe aim of this study was to find the significance of RH in patients with FDD and the related factors of RH.MethodsPatients with FDD first completed clinical questionnaires regarding constipation symptoms, mental state, and quality of life. Then anorectal physiologic tests (anorectal manometry and balloon expulsion test) were performed. Rectal sensory testing (assessing rectal response to balloon distension using anorectal manometry) was applied to obtain three sensory thresholds. Patients were separated into three groups (non-RH, borderline RH, and RH) based on the London Classification. The associations between RH and clinical symptoms, mental state, quality of life, and rectal/anal motility were investigated.ResultsOf 331 included patients with FDD, 87 patients (26.3%) had at least one abnormally elevated rectal sensory threshold and 50 patients (15.1%) were diagnosed with RH. Patients with RH were older and mostly men. Defecation symptoms were more severe (p = 0.013), and hard stool (p &lt; 0.001) and manual maneuver (p = 0.003) were more frequently seen in the RH group. No difference in rectal/anal pressure was found among the three groups. Elevated defecatory desire volume (DDV) existed in all patients with RH. With the number of elevated sensory thresholds increasing, defecation symptoms got more severe (r = 0.35, p = 0.001). Gender (male) (6.78 [3.07–15.00], p &lt; 0.001) and hard stool (5.92 [2.28–15.33], p &lt; 0.001) were main related factors of RH.ConclusionRectal hyposensitivity plays an important role in the occurrence of FDD and is associated with defecation symptom severity. Older male FDD patients with hard stool are prone to suffer from RH and need more care.
Enhanced phosphatidylserine exposure and erythropoiesis in Babesia microti-infected mice
Authors: Song Peng , Cai Yu-Chun , Chen Mu-Xin , Chen Shao-Hong , Chen Jia-Xu 
Published: February 2023

IntroductionBabesia microti (B. microti) is the dominant species responsible for human babesiosis, which is associated with severe hemolytic anemia and splenomegaly because it infects mammalian erythrocytes. The actual prevalence of B. microti is thought to have been substantially underestimated.MethodsIn this study, Bagg’s albino/c (BALB/c) mice were intraperitoneally injected with B. microti-infected erythrocytes, and parasitemia was subsequently measured by calculating the proportion of infected erythrocytes. The ultrastructure of infected erythrocytes was observed using scanning and transmission electron microscopes. Quantifying phosphatidylserine (PS) exposure, oxidative stress, intracellular Ca2+, and erythropoiesis of erythrocytes were done using flow cytometry. The physiological indicators were analyzed using a Mindray BC-5000 Vet automatic hematology analyzer.ResultsOf note, 40.7 ± 5.9% of erythrocytes changed their structure and shrunk in the B. microti-infected group. The percentage of annexin V-positive erythrocytes and the levels of reactive oxygen species (ROS) in the erythrocytes were higher in the B. microti-infected group than in the control group at 10 dpi. Significant splenomegaly and severe anemia were also observed following B. microti infection. The parasitemia level in the B. microti-infected splenectomized group was higher than that of the B. microti-infected sham group. The population of early erythroblasts increased, and the late erythroblasts decreased in both the bone marrow and spleen tissues of the B. microti-infected group at 10 dpi.DiscussionPS exposure and elevated ROS activities were hallmarks of eryptosis in the B. microti-infected group. This study revealed for the first time that B. microti could also induce eryptosis. At the higher parasitemia phase, the occurrence of severe anemia and significant changes in the abundance of erythroblasts in B. microti-infected mice group were established. The spleen plays a critical protective role in controlling B. microti infection and preventing anemia. B. microti infection could cause a massive loss of late erythroblasts and induce erythropoiesis.
A progression analysis of motor features in Parkinson's disease based on the mapper algorithm
Authors: Ma Ling-Yan , Feng Tao , He Chengzhang , Li Mujing , Ren Kang , Tu Junwu 
Published: February 2023

BackgroundParkinson's disease (PD) is a neurodegenerative disease with a broad spectrum of motor and non-motor symptoms. The great heterogeneity of clinical symptoms, biomarkers, and neuroimaging and lack of reliable progression markers present a significant challenge in predicting disease progression and prognoses.MethodsWe propose a new approach to disease progression analysis based on the mapper algorithm, a tool from topological data analysis. In this paper, we apply this method to the data from the Parkinson's Progression Markers Initiative (PPMI). We then construct a Markov chain on the mapper output graphs.ResultsThe resulting progression model yields a quantitative comparison of patients' disease progression under different usage of medications. We also obtain an algorithm to predict patients' UPDRS III scores.ConclusionsBy using mapper algorithm and routinely gathered clinical assessments, we developed a new dynamic models to predict the following year's motor progression in the early stage of PD. The use of this model can predict motor evaluations at the individual level, assisting clinicians to adjust intervention strategy for each patient and identifying at-risk patients for future disease-modifying therapy clinical trials.
The development of neurocritical care in China from the perspective of evaluation and treatment of critical neurological diseases
Authors: Su Yingying , Teng Junfang , Tian Fei , Jing Jing , Huang Huijin , Pan Suyue , Jiang Wen , Wang Furong , Zhang Le , Zhang Yan , Zhang Meng , Liu Liping , Cao Jie , Hu Huaiqiang , Li Wei , Liang Cheng , Ma Liansheng , Meng Xuegang , Tian Linyu , Wang Changqing , Wang Lihua , Wang Yan , Wang Zhenhai , Wang Zhiqiang , Xie Zunchun , You Mingyao , Yuan Jun , Zeng Chaosheng , Zeng Li , Zhang Lei , Zhang Xin , Zhang Yongwei , Zhao Bin , Zhou Saijun , Zhou Zhonghe 
Published: February 2023

ObjectiveTo understand the varieties, evaluation, treatment, and prognosis of severe neurological diseases using the third NCU survey in China.DesignA cross-sectional questionnaire study. The study was completed in three main steps: filling in the questionnaire, sorting out the survey data, and analyzing the survey data.ResultsOf 206 NCUs, 165 (80%) provided relatively complete information. It was estimated that 96,201 patients with severe neurological diseases were diagnosed and treated throughout the year, with an average fatality rate of 4.1%. The most prevalent severe neurological disease was cerebrovascular disease (55.2%). The most prevalent comorbidity was hypertension (56.7%). The most prevalent complication was hypoproteinemia (24.2%). The most common nosocomial infection was hospital-acquired pneumonia (10.6%). The GCS, APACHE II, EEG, and TCD were the most commonly used (62.4–95.2%). The implementation rate of the five nursing evaluation techniques reached 55.8–90.9%. Routinely raising the head of the bed by 30°, endotracheal intubation and central venous catheterization were the mostprevalent treatment strategies (97.6, 94.5, and 90.3%, respectively). Traditional tracheotomy, invasive mechanical ventilation and nasogastric tube feeding (75.8, 95.8, and 95.8%, respectively) were more common than percutaneous tracheotomy, non-invasive mechanical ventilation and nasogastric tube insertion (57.6, 57.6, and 66.7%, respectively). Body surface hypothermia brain protection technology was more commonly used than intravascular hypothermia technology (67.3 &gt; 6.1%). The rates of minimally invasive hematoma removal and ventricular puncture were only 40.0 and 45.5%, respectively.ConclusionIn addition to traditional recognized basic life assessment and support technology, it is necessary to the use of promote specialized technology for neurological diseases, according to the characteristics of critical neurological diseases.
Case series: Immune checkpoint inhibitor-induced transverse myelitis
Authors: Chatterton Sophie , Xi Shuo , Jia Jessica Xi , Krause Martin , Long Georgina V. , Atkinson Victoria , Menzies Alexander M. , Fernando Suran L. , Boyle Thérèse , Kwok Samuel , Duggins Andrew , Karikios Deme , Parratt John D. E. 
Published: February 2023

IntroductionIncreasing implementation of the highly efficacious immune checkpoint inhibitors (ICIs) has raised awareness of their various complications in the form of immune-related adverse events (irAEs). Transverse myelitis following ICIs is thought to be a rare but serious neurologic irAE and knowledge is limited about this distinct clinical entity.CasesWe describe four patients across three tertiary centers in Australia with ICI-induced transverse myelitis. Three patients had a diagnosis of stage III–IV melanoma treated with nivolumab and one patient had stage IV non-small cell lung cancer treated with pembrolizumab. All patients had longitudinally extensive transverse myelitis on magnetic resonance imaging (MRI) spine and clinical presentation was accompanied by inflammatory cerebrospinal fluid (CSF) findings. Half of our cohort had received spinal radiotherapy, with the areas of transverse myelitis extending beyond the level of previous radiation field. Inflammatory changes on neuroimaging did not extend to the brain parenchyma or caudal nerve roots, except for one case involving the conus medullaris. All patients received high dose glucocorticoids as first-line therapy, however the majority relapsed or had a refractory state (3/4) despite this, requiring escalation of their immunomodulation, with either induction intravenous immunoglobulin (IVIg) or plasmapheresis. Patients in our cohort who relapsed had a poorer outcome with more severe disability and reduced functional independence following resolution of their myelitis. Two patients had no progression of their malignancy and two patients had malignancy progression. Of the three patients who survived, two had resolution of their neurological symptoms and one remained symptomatic.ConclusionWe propose that prompt intensive immunomodulation is favored for patients with ICI-transverse myelitis in an attempt to reduce associated significant morbidity and mortality. Furthermore, there is a significant risk of relapse following cessation of immunomodulatory therapy. We suggest one treatment approach of IVMP and induction IVIg for all patients presenting with ICI-induced transverse myelitis based on such findings. With the increasing use of ICIs across oncology, further studies are required to explore this neurological phenomenon in greater detail to help establish management consensus guidelines.
Nutritional interventions in adult fibrostenotic Crohn’s disease: A systematic review
Authors: Cooper Jared L. , Rosentreter Ryan E. , Filyk Alexis , Premji Zahra A. , Shen Hua , Ingram Richard , Kaplan Gilaad G. , Ma Christopher , Novak Kerri , Panaccione Remo , Seow Cynthia H. , Rieder Florian , Raman Maitreyi , Lu Cathy 
Published: February 2023

BackgroundManagement of Crohn’s disease (CD) using dietary interventions has become an area of increased research interest. There is a lack of specific research exploring if diet and nutrition interventions are beneficial in patients with strictures, as current dietary recommendations in fibrostenotic CD are often based on clinical judgment. The aim of this systematic review was to assess the impact of dietary interventions in fibrostenotic CD on medical and surgical outcomes.MethodsA systematic search of MEDLINE (Ovid), EMBASE (Ovid), CINAHL (EBSCO), and Cochrane Central Register of Controlled Trials (Ovid) was conducted. Studies reporting dietary interventions or nutritional factors in fibrostenotic CD were included. Outcomes for studies assessing dietary interventions such as enteral nutrition were evaluated as changes in (1) CD symptoms (CD Activity Index), (2) stricture parameters on diagnostic imaging, and (3) rates of surgical or medical intervention following dietary interventions.ResultsFive studies were included in this review. Three studies assessed exclusive enteral nutrition (EEN), one evaluated total parenteral nutrition (TPN), and one studied a liquid diet. All included studies evaluated symptoms as an outcome, while diagnostic imaging parameters and surgical outcomes in the studies were either absent or too heterogeneous to appraise improvement post dietary intervention. Included EEN studies displayed similar efficacy, with approximately 60% of patients having symptom improvement. The included TPN study also reported 75% of patients with symptom improvement, while the liquid diet did not.ConclusionExclusive enteral nutrition and total parental nutrition may provide benefit for use as a dietary intervention for fibrostenotic CD. There remains a need for high-quality controlled trials which utilize standardized definitions of strictures.