bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photocatalytic degradation mechanism of pharmaceutical agent salbutamol using Mn-doped TiO 2 nanoparticle under visible light irradiation
Authors: Mingmongkol Yumatorn , Polnok Assadang , Phuinthiang Patcharaporn , Channei Duangdao , Ratananikom Khakhanang , Nakaruk Auppatham , Khanitchaidecha Wilawan 
Published: March 2023

Abstract
In this present work, the photocatalytic degradation of salbutamol [2-(tert-butylamino)-1-(4-hydroxyl-3-hydroxymethylphenyl)ethanol] under visible irradiation using Mn-doped TiO2. The Mn-doped TiO2 nanoparticles were synthesized by sol-gel method with the ratio of 0.1%, 0.2% and 0.3%. The significant characteristics including rutile/anatase phase ratio, specific surface area and band gap energy was due to the amount of Mn doping; the narrowest band gap energy of 2.80 eV was observed in the 0.2% Mn-doped TiO2 with the specific surface area of 89.36 m2/g and 10.87/ 89.13 of rutile/anatase phase. The investigation involved salbutamol photocatalytic degradation, kinetic study and identification of intermediate compounds. The results indicated that the 0.2% Mn-doped TiO2 obtained the best salbutamol removal of 95% under irradiation time of 180 min. The salbutamol was slowly degraded to the intermediate compounds in the first 60 min (k = 0.0088 1/min) and they was dramatically mineralized to small hydrocarbon fragments and carbon dioxide in the later irradiation times (k = 0.0179 1/min). According to the HPLC-MS results, the possible degradation pathways of salbutamol were proposed; 2-(tert-butylamino)-1-(3,4-dihydroxyphenyl)ethanone, 2-(tert-butylamino)-ethanol and 2-(tert-butylamino)-1-(4-hydroxyl-3-hydroxymethylphenyl)ethanone were initially formed and then transformed to 2-(methylamino)-1-(3,4-dihydroxyphenyl)ethanone, 2-(tert-butylamino)-acetic acid, hydroqunone and 1-(4-hydroxylphenyl)ethanol. The mineralization of all intermediate compounds was verified by 90% of COD reduction and the effluent contained relatively low COD concentration of 7.8 mg/L.
Lower dietary magnesium is associated with a higher hemoglobin glycation index in the National Health and Nutrition Examination Survey
Authors: Chen Juan , Lin Song , Wang Xingzhou , Wang Xiwei , Gao Pengxia 
Published: March 2023

Abstract
Background and Aims:
The data for the effect of dietary magnesium (Mg) on hemoglobin glycation index (HGI) is limited. Thus, this study aimed to examine the relationship between dietary Mg and HGI in the general population.
Methods and Results
Our research used data from the National Health and Nutrition Examination Survey from 2001 to 2002. The dietary intake of Mg was assessed by two 24-h dietary recalls. The predicted HbA1c was calculated based on fasting plasma glucose. Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary Mg intake and HGI. We found a significant inverse association between dietary Mg intake and HGI (β = -0.00016, 95%CI: -0.0003, -0.00003, P = 0.019). Dose-response analyses revealed that HGI decreased with increasing intakes of Mg when reached the point above 412 mg/d. There was a linear dose-response relationship between dietary Mg intake and HGI in diabetic subjects, and there was an L-shape dose-response relationship in non-diabetic individuals.
Conclusion
Increasing the intake of Mg might help lower the risk associated with high HGI. Further prospective studies are requested before dietary recommendations.
Measurement of δ18O in water vapor using a tunable diode laser based spectrometer
Authors: Zhang Jian , Du Junya , Jiang Cong , He Tianbo , Li Jingsong 
Published: March 2023

Abstract
A system based on the tunable diode laser absorption spectroscopy (TDLAS) was described, ensuring the real-time, continuity, high-precision, and rapid time response measurement of the isotope ratio of 18O/16O in water vapor from 3729.8 cm− 1 to 3730.8 cm− 1. A detailed description of the system's implementation was provided and the precision and accuracy of the measurement system were analyzed after verification in the laboratory environment. The absorbance achieved a high signal-to-noise ratio (SNR) with a 20.4 cm optical path and was compared to HITRAN simulations. Allan variance was used to evaluate the reliability of the system and the results showed that the precision of the 18O/16O ratio was 5.274‰ at 1 s and improved to 0.088‰ at 191 s. The system provides the potential for applications in environmental, geological, ecological, and energy fields, and additional information for comparison and standard development in determining oxygen isotope composition in water vapor via laser spectrometry.
Clinicopathological Characteristics of Jugulo-omohyoid Lymph Nodes Metastasis incorporating Its Nanogram to Predict Lateral Lymph Node Metastasis in Papillary Thyroid Cancer
Authors: Cai Huizhu , Zhuge Lingdun , Huang Zehao , Wang Shixu , Shi Ping , Yan Dangui , Niu Lijuan , Li Zhengjiang 
Published: March 2023

Abstract
Background
Jugulo-omohyoid lymph nodes (JOHLN) metastasis has proven to be associated with lateral lymph node metastasis (LLNM). This study aimed to reveal the clinical features and evaluate the predictive value of JOHLN in PTC to guide the extent of surgery. This is the first study of the nanogram to predict LLNM using JOHLN.
Methods
A total of 550 patients pathologically diagnosed with PTC between October 2015 and January 2020, all of whom underwent thyroidectomy and lateral lymph node dissection, were included in this study.
Results
Thyroiditis, tumor location, tumor size, extra-thyroidal extension, extra-nodal extension, central lymph node metastasis (CLNM) and LLMM were associated with JOHLN. And male, upper lobe tumor, multifocality, extra-nodal extension, CLNM and JOHLN metastasis were independent risk factors from LLNM. A nomogram based on upon predictors performed well. Nerve invasion contributed the most to the prediction model, followed by JOHLN metastasis. The area under the curve (AUC) was 0.855, and the p-value of the Hosmer-Lemeshow goodness of fit test was 0.18. Decision curve analysis showed that the nomogram was clinically helpful.
Conclusions
JOLHN metastasis could be a clinically sensitive predictor of further LLM, especially the lateral compartment. A high-performance nomogram was established, which can provide an individual risk assessment of LNM and guide treatment decisions for patients.
Trial registration:
This study was approved by the ethics committee of the Cancer Hospital of Chinese Academy of Medical Sciences (reference number: NCC2016ST-23).
In silico molecular docking analysis of Equisetum diffusum D. Don phytocompounds against potent inflammatory markers and validating its role through in vitro and in vivo anti-inflammatory assays.
Authors: Sarkar Sourav , Modak Debabrata , Haydar Md. Salman , Georrge John J. , Bhattacharjee Soumen 
Published: March 2023

Abstract
Equisetum diffusum D. Don (Fam. Equisetaceae), commonly known as ‘Himalayan horsetail’, is an important medicinal pteridophyte species having various ethnobotanical properties; and traditionally been used in the treatment of back pain, bone fracture, bone dislocation, and arthritis by various tribal communities of India. Although the pharmacological uses are known, no study related to its ethnobotanical validation in experimental animal models has been reported till date. The goal of the present study was to validate the anti-inflammatory properties of the whole plant methanolic-extract (EDME) using in silico, in vitro, and in vivo strategies. The GC-MS analysis of EDME detected the presence of 47 phyto-compounds, out of which Stigmasta-3,5-dien-7-one and 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl showed good inhibition of cyclooxygenase-2 (Cox-2) and IL-6 respectively compared to standard NSAIDs, in docking analysis. In vitro anti-inflammatory studies indicated that EDME inhibits 48.2 ± 3.74% of protein denaturation at a concentration of 1000 µg/ml compared to standard diclofenac sodium (57.6 ± 3.70% at 100 µg/ml concentration). The similar concentration (1000 µg/ml) of extract inhibits heat-induced (33.6 ± 2.55%) and hypotonicity-induced (58.1 ± 3.39%) erythrocyte membrane lyses respectively, compared to indomethacin standard (45.6 ± 2.36% and 67.2 ± 1.45% respectively at 200 µg/ml concentration). The in vivo anti-inflammatory study of EDME showed 52.26% and 73.36% reduction in paw-edema in both low and high dose protective groups respectively, when compared to the carrageenan control-group. Our findings established the anti-inflammatory roles of the whole plant methanolic extract of Equisetum diffusum on strong ground which may encourage drug-development for the treatment of inflammation-related complications.
Clinical and Imaging Findings for the Evaluation of Large Rathke’s Cleft Cysts and Cystic Craniopharyngiomas
Authors: Yang Chung-Han , Wu Chia-Hung , Lin Te-Ming , Chen Shu-Ting , Tai Wei-An , Yu Kai-Wei , Luo Chao-Bao , Lirng Jiing-Feng , Chang Feng-Chi 
Published: March 2023

Abstract
Purpose

Large Rathke’s cleft cysts (LRCCs) and cystic craniopharyngiomas (CCPs) arise from the same embryological origin and may have similar MR presentations. However, the two tumors have different management strategies and outcomes. This study was designed to evaluate the clinical and imaging findings of LRCCs and CCPs, aiming to evaluate their pretreatment diagnosis and outcomes.

Methods

We retrospectively enrolled 20 patients with LRCCs and 25 patients with CCPs. Both tumors had a maximal diameter of more than 20 mm. We evaluated the patients’ clinical and MR imaging findings, including symptoms, management strategies, outcomes, anatomic growth patterns and signal changes.

Results

The age of onset for LRCCs versus CCPs was 49.0 ± 16.8 versus 34.2 ± 22.2 years (p = .022); the following outcomes were observed for LRCCs versus CCPs: 1) postoperative diabetes insipidus: 6/20 (30%) versus 17/25 (68%) (p = .006); and 2) posttreatment recurrence: 2/20 (10%) versus 10/25 (40%) (p = .025). The following MR findings were observed for LRCCs versus CCPs: 1) solid component: 7/20 (35%) versus 21/25 (84%) (p = .001); 2) thick cyst wall: 2/20 (10%) versus 12/25 (48%) (p = .009); 3) intracystic septation: 1/20 (5%) versus 8/25 (32%) (p = .030); 4) snowman shape: 18/20 (90%) versus 1/25 (4%) (p < .001); 5) off-midline extension: 0/0 (0%) versus 10/25 (40%) (p = .001); and 6) oblique angle of the sagittal long axis of the tumor: 89.9° versus 107.1° (p = .001).

Conclusions

LRCCs can be differentiated from CCPs based on their clinical and imaging findings, especially their specific anatomical growth patterns. We suggest using the pretreatment diagnosis to select the appropriate surgical approach and thus improve the clinical outcome.
Serum and urinary cadmium and zinc profiles in breast cancer patients and their association with estrogen and HER-2 receptors, and redox status
Authors: Matin Mehrnoush , Salehcheh Maryam , Ahmadzadeh Ahmad , Khorasgani Zahra Nazari , Khodayar Mohammad Javad 
Published: March 2023

Abstract
Background: Cadmium, a metal implicated in environmental toxicity, is linked to tumor growth and cancer. On the other hand, zinc plays an essential function in oxidative stress and can counteract cadmium toxicity and carcinogenicity.
This research aims to evaluate the urine and serum values of cadmium and zinc in breast cancer (BC) patients and their association with estrogen (ER) and HER-2 receptors, and redox status.
Methods: Forty BC patients and thirty healthy subjects participated in this study. Cadmium and zinc levels were measured in serum and urine samples by atomic absorption spectrophotometer. Redox status markers were determined by calorimetric methods.
Results: The amount of cadmium in the BC patients was substantially greater than in the healthy subjects. Zinc levels were significantly lower in patients with BC compared to controls. Breast cancer patients with ER-positive tumors had significantly higher urinary cadmium concentrations (U-Cd) compared to patients with ER-negative tumors. There was no significant difference between the parameters of redox status and the value of cadmium and zinc between patients with BC in the HER-2 subgroup. Malondialdehyde levels in the serum were substantially greater in BC patients than in healthy subjects. Total thiol level and the activity of catalase and superoxide dismutase in serum were considerably lower in BC patients than in healthy subjects.
Conclusions: Breast cancer etiology may be influenced by disturbing redox state and element levels. Increasing U-Cd and lowering zinc levels in the serum could be the risk factors for BC.
Two modified adaptive parameter conjugate gradientmethods for unconstrained optimization
Authors: Luo Wenjun , Wu Zezhong 
Published: March 2023

Abstract
In this work, several convex combinations of conjugate gradient methods are proposed. The parameters of convex combinations are based on memory-less BFGS method. We prove the global convergence of these algorithms under Wolfe condition and compare it with others conjugate gradient method using the CUTEst library. The results show that the proposed algorithm is more efficient and robust than the classical algorithm.
Non-radial ground state solutions for fractional Schrödinger–Poisson systems in ℝ2
Authors: Che Guofeng , Sun Juntao , Wu Tsung-fang 
Published: March 2023

Abstract
Note: Please see pdf for full abstract with equations.
In this paper, we study the fractional Schrödinger–Poisson system with general nonlinearity as follows:
(−∆)su + u + l(x)φu = ƒ(u) in R2,
(−∆) tφ = l(x)u2 in R2,
where 1/2 < t ≤ s < 1, the potential l ∈ C(R2, R+) and the nonlinearity ƒ ∈ C(R,R) does not require the classical (AR)-condition. When l(x) ≡ µ > 0 is a parameter, by establishing new estimates for the fractional Laplacian, we find two positive solutions, depending on the range of µ. As a result, a positive ground state solution with negative energy exists for the non-autonomous system without any symmetry on l(x). When l(x) is radially symmetric, we show that the symmetry breaking phenomenon can occur, and that a non-radial ground state solution with negative energy exists. Furthermore, under additional assumptions on l(x), three positive solutions are found. The intrinsic differences between the planar SP system and the planar fSP system are analyzed.
2020 Mathematics Subject Classification. Primary: 35B38; Secondary: 35J60
The Importance of Plant Signs in Local Environmental Knowledge Construction and its Implications for Conservation of Landscape and Natural Resources in a Savanna Forest (Caatinga) in Brazilian Northeastern: A Biosemiotic Approach
Authors: Silva Arthur Lima , Mira Feliciano 
Published: March 2023

Abstract
This study investigated the role of plant signs in environmental knowledge construction in the quilombola community Baixa dos Quelés (Bahia, Brazil) and the implications of such knowledges in the conservation of natural resources. Plant signs play a central role in local environmental knowledge construction, participating in the forecast of climatic conditions, predicting rainy season, selecting cultivated species, indicating soil types, and pinpointing water resources. However, such informative networks are not taken into consideration in scientific studies, which instead choose classical methods for conducting flora inventory.
Analysis of different criteria and simulation parameters influence on three-dimensional plasticity induced crack closure loads
Authors: Baptista R. , Infante V. 
Published: March 2023

Abstract
Fracture due to fatigue crack growth is still a prevalent failure mode in both brittle and ductile materials. While experimental procedures are fundamental to capture material behaviour in the presence of structural damage, numerical models allow for accessible fracture mechanics analysis. When dealing with crack tip plasticity induced phenomena, characterized by high strain and stress field gradients, only very refined meshes around the crack tip can produce accurate results. Therefore, optimized mesh parameters must be used, in order to achieve high quality models with low computational costs. In the present study, a three-dimensional model for a middle tension specimen has been developed, and the influence of the element size and simulated plastic wake over the resulting crack closure loads was determined. The numerical accuracy is analysed regarding the estimated stress and strain fields, stress intensity factors, plastic zone shape and size and crack opening and closure values. Two different crack sizes were analysed, for a constant load amplitude. The optimal parameters to be used include a minimum element size around 60 times smaller than the resulting plastic zone and a simulated plastic wake of about 60% of the resulting plastic zone. These parameters can be used with different geometries, in order to predict structural integrity and damage tolerance.
Referral order placement decreases time to transfer to adult congenital heart disease care.
Authors: Burger Debora , Denfeld Quin , Evers Patrick , Ward Pam , Woods Patricia , Hasan Reem 
Published: March 2023

Abstract
Background
Pediatric patients with moderate and great complexity congenital heart disease (CHD) may benefit from coordinated transfer to adult congenital heart disease (ACHD) centers to reduce the risk of complications; however, there are a variety of transfer practices. We examined the impact of referral order placement at the last pediatric cardiology visit on time to transfer to an ACHD center.
Methods
We analyzed data collected from pediatric patients with moderate and great complexity CHD who were eligible to transfer to our tertiary center’s accredited ACHD center. We examined transfer outcomes and time-to-transfer between those with a referral order placed at the last pediatric cardiology visit and those without using Cox proportional hazards modeling.
Results
The sample (n = 65) was 44.6% female and mean age at study start was 19.5 years (± 2.2). Referral orders were placed for 32.3% of patients at the last pediatric cardiology visit. Those who had a referral order placed at the last visit had significantly higher number of successful transfers to the ACHD center compared to those who did not (95% vs 25%, p < 0.001). In a Cox regression model, placement of a referral order at the last pediatric cardiology visit was associated significantly with a sooner time to transfer (HR 6.0; 95% CI 2.2–16.2, p > 0.001), adjusting for age, sex, complexity, living location, and pediatric cardiology visit location.
Conclusions
Placement of a referral order at the last pediatric cardiology visit may improve transfer occurrence and time to transfer to accredited ACHD centers.
Mechanical model establishment and energy characteristics analysis for rock material considering the dynamic disturbance effect
Authors: Feng Chenchen , Wang Zhiliang , Wang Jianguo , Li Songyu 
Published: March 2023

Abstract
An element mechanical assembly model was established with the combined modeling method to study the dynamic damage behaviors of deep rock. In this model, the effect of disturbance and pre-static loading on the rock mechanics and statistical parameters was considered and a modified function was introduced to deduce the damage evolution function, thus a mechanical model of rock was established. This model was verified against the relevant experimental and bibliographic data. The results show that the damage evolution rate curve gradually moves to the right along the strain axis and the peak value of curve decreases first and then increases with increasing parameter k. When k is large, the damage evolution rate appears a “plateau” which is more obvious as k gets higher. This “plateau” may correspond to the damage stable development stage. Further, the pre-static loading can improve the resistance to impact of rock. The released energy of rock in the rebound under pre-static loading is higher than that under no pre-static loading with the constant disturbance frequency. It decreases with disturbance numbers rising as the pre-static loading remains unchanged, which indicates the resistance to impact of rock is weakened by adding disturbance frequency. These predictions were consistent with test data in pre-peak stage of “rebound” type curve. For strain-softening type curves, this model did not only fit preferably with test data in the pre-peak stage but also had high fitting accuracy in the post-peak stage. This model can well characterize the mechanical properties and stress-strain behaviors of rock under the combination of static loading and frequent disturbance. These results can provide certain references for the evaluation of the safety and stability of deep rock engineering under high ground stress and frequent dynamic disturbance.
The induction of potent anti-tumor efficacy in diffuse intrinsic pontine glioma by YF-PRJ8-1011 of a novel cyclin-dependent kinase 4/6 inhibitor
Authors: Zuo Pengcheng , Li Yaopeng , Wang Tantan , Lin Xingyu , Wu Zhen , Zhang Junting , Liao Xuebin , Zhang Liwei 
Published: March 2023

Abstract
Objective
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brainstem tumor. Despite numerous efforts to improve survival benefits, its prognosis remains poor. This study aimed to design and synthesize a novel CDK4/6 inhibitor YF-PRJ8-1011, which exhibited more potent antitumor activity against a panel of patient-derived DIPG tumor cells in vitro and in vivo compared with palbociclib.
Methods
Patient-derived DIPG cells were used to assess the antitumor efficacy of YF-PRJ8-1011 in vitro. The Liquid chromatography tandem-mass spectrometry (LC-MS/MS) method was used to measure the activity of YF-PRJ8-1011 passing through the blood-brain barrier. DIPG patient-derived xenograft models were established to detect the antitumor efficacy of YF-PRJ8-1011.
Results
The results showed that YF-PRJ8-1011 could inhibit the growth of DIPG cells both in vitro and in vivo. YF-PRJ8-1011 could well penetrate the blood-brain barrier. It also significantly inhibited the growth of DIPG tumors and prolonged the overall survival of mice compared with vehicle or palbociclib. Most notably, it exerted potent antitumor efficacy in DIPG in vitro and in vivo compared with palbociclib. In addition, we also found that YF-PRJ8-1011 combined with radiotherapy also showed more significant inhibition of DIPG xenograft tumor growth than radiotherapy alone.
Conclusion
Collectively, YF-PRJ8-1011 is a novel, safe, and selective CDK4/6 inhibitor for DIPG treatment.
Learning performance of grey mouse lemurs (Microcebus murinus) during a visual discrimination task: effect of the stimuli’s emotional value
Authors: Mortessagne Eugénie , Bovet Dalila , Nozières Camille , Pouydebat Emmanuelle , Pifferi Fabien 
Published: March 2023

Abstract
While the interaction between emotions and cognition is relatively well known in humans, it remains to be explored in non-human primates, whose dedicated studies are carried out on a limited diversity of species, preventing us from discussing the evolutionary origin of this interaction. Here, we explored this cognition-emotion interaction in the grey mouse lemur (Microcebus murinus), often described as possessing ancestral characteristics, allowing us to better comprehend if this link appears soon in the phylogeny of primate. We tested whether emotions could modify the learning performance of 60 mouse lemurs during a visual discrimination task. In this task, individuals had to learn to discriminate between two platforms using emotionally valued visual stimuli and to jump on the target platform. Our results showed that individuals learning performance improved when distractors had an emotional valence compared to when they were neutral. Opposite, individuals had impaired learning performance when targets had an emotional valence compared to when they were neutral. These results are consistent with the cognitive avoidance pattern for negative stimuli reported in other studies. This study is the first to explore emotion in mouse lemurs and to demonstrate that the emotion-cognition interaction is already present in a lemur’s species.