bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ein Moses und sein Josua
Authors: Fitzek Herbert 
Published: March 2023

ZusammenfassungDie Gründungsgeschichte der Psychoanalyse ist entscheidend geprägt durch das Arbeitsbündnis von Sigmund Freud und C.G. Jung, das zwischen 1906 und 1913 einen stürmischen Verlauf von persönlicher Attraktivität über effiziente Zusammenarbeit bis zur schmerzlichen Enttäuschung von Erwartungen und endgültigem Bruch miteinander nahm. Es wird gezeigt, dass die Missstimmungen zwischen den beiden Integrationsfiguren der frühen Tiefenpsychologie nicht in erster Linie durch konzeptuelle Differenzen entstanden: Beide kamen sich auf dem Gebiet einer tiefenpsychologisch fundierten Kulturpsychologie in den Jahren ihrer Freundschaft näher und lernten individuelle psychische Konflikte als Ausdruck historischer kultureller Problemkonstellationen zu lesen, wie sie in Mythen und Märchen verhandelt werden. Auch die persönliche Nähe zwischen Lehrer (Freud) und Schüler (Jung) führte nicht als solche zu einer wachsenden Rivalität und Entfremdung. Vielmehr interpretierten beide die Art ihrer Beziehung zueinander und die daraus erwachsenden Herausforderungen auf fatal unterschiedliche Art und Weise, wie an der Wahl ihrer Beispiele für ödipale Beziehungen im Briefwechsel und gleichzeitig entstehenden Werken gezeigt werden kann. Dass Freud sich in der alttestamentarischen Figur des „Moses“ wiederfand, ist bekannt – Jung sah er von da aus als „Josua“ an seiner Seite. Da passte etwas nicht und Jung antwortete bewusst oder unbewusst mit einem Bild aus dem neuen Testament, das Freud wiederum nicht behagen konnte …
Preparing for the Next Pandemic: Has COVID-19 Changed American Attitudes?
Authors: Warren May Linnea , Yeung Douglas , Bugliari Delia , Chandra Anita 
Published: March 2023

Abstract

Objective:
Coronavirus disease 2019 (COVID-19) and future pandemics have become a reality, and planners must understand how attitudes during COVID-19 may influence future preparedness activities. This study explores how personal experiences of Americans during the pandemic, attitudes about institutions, and views of social change could either pose challenges or help with planning for the next pandemic.

Methods:
A longitudinal survey capturing health attitudes and COVD-19-related experiences was fielded 3 times over the course of the pandemic among historically underserved individuals in US society (racial/ethnic minority and low-income populations).

Results:
COVID-19-related experiences increased over time. Attitudes about federal and state government and businesses’ ability to respond to the pandemic varied by COVID-19-related experience and having any COVID-19-related experience was associated with a lower likelihood of reporting positive attitudes about institutions. Respondents generally perceived that COVID-19 presented an opportunity for positive social change, and those with COVID-19-related experiences had the greatest likelihood of selecting “reduce income inequality” as their top prioritized change. Those with COVID-19-related experiences were less likely to endorse other policy priorities such as protecting freedoms.

Conclusions:
Anticipating potential backlash or other sentiments could improve pandemic responsiveness. Strengthening public institutions is crucial to ensuring their effectiveness during a pandemic. Pandemic planning could exploit opportunities to take other social policy actions where views seem to converge.
Military ad hoc coalitions and functional differentiation in inter-organisational relations
Authors: Brosig Malte 
Published: March 2023

AbstractThe emergence of military ad hoc coalitions (AHCs) in Africa as a tool for conflict management outside established institutional frameworks brings about a number of questions: are they undermining existing security structures such as the African Peace and Security Architecture (APSA) or are they contributing to further regime complexity? In order to answer these questions, the article applies the logic of functional differentiation as it is used in the literature on regime complexity and inter-organisational studies. Scope conditions are developed exploring when and how functional differentiation operates and what consequences it brings about for interacting institutions. Empirically the example of military ad hoc coalitions in the Lake Chad Basin and Sahel is at the centre of analysis. It will be argued that ad hoc coalitions are part of a functionally differentiated system response within the African Security Regime Complex and not in direct competition to the APSA.
MicroRNAs in cancer metastasis: biological and therapeutic implications
Authors: Sell Marie C. , Ramlogan-Steel Charmaine A. , Steel Jason C. , Dhungel Bijay P. 
Published: March 2023

Abstract
Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary tumours at a secondary site is a highly inefficient process requiring substantial alterations in the genetic architecture of cancer cells. These alterations include significant changes in global gene expression patterns. MicroRNAs are small, non-protein coding RNAs which play a central role in regulating gene expression. Here, we focus on microRNA determinants of cancer metastasis and examine microRNA dysregulation in metastatic cancer cells. We dissect the metastatic process in a step-wise manner and summarise the involvement of microRNAs at each step. We also discuss the advantages and limitations of different microRNA-based strategies that have been used to target metastasis in pre-clinical models. Finally, we highlight current clinical trials that use microRNA-based therapies to target advanced or metastatic tumours.
Facilitating transition from maternity leave to work for working mothers: A self-efficacy intervention study
Authors: Kokubo Akiko , Yoshikawa Katsuhiko , Wu Chia-Huei 
Published: March 2023

Abstract
The return from maternity leave to work is a critical career transition period for working mothers. To help their readaptation to work, we developed and examined a training program for cultivating their work–family balance self-efficacy in a pretest–posttest design and investigated the time-lagged effect of the boosted self-efficacy on their employment attitude and in-role performance after they returned to work. Data were collected from 100 maternity leave takers from 16 companies in Japan before the training (Time 1), immediately after it (Time 2) and 6 months after returning to work (Time 3), and from their supervisors at Time 3. We found that maternity leave takers displayed an increase in work–life balance self-efficacy after the training. We also found that work–life balance self-efficacy after the training (Time 2) predicted the participants’ in-role performance (Time 3) reported by their supervisors, but not employment attitude reported by the participants (Time 3). Our study thus offers preliminary evidence supporting the effectiveness of the training program in helping maternity leave takers’ readaptation to work, potentially supplementing existing family-friendly policies.
Benthic infauna associated with a shallow-water hydrothermal system of Punta Mita (Mexico)
Authors: Rodríguez-Uribe M. C. , Núñez-Cornú F. J. , Prol-Ledesma R. M. , Salazar-Silva P. 
Published: March 2023

Abstract
The shallow-water hydrothermal system of Punta Mita in Banderas Bay is located on the fault called Fisura de las Coronas off Punta Pantoque beach. In this area, three sites with hydrothermal vents were studied at a depth of 9 m. This study aimed to characterize the structure of the benthic infauna communities that coexist in this hydrothermal system; therefore, physicochemical parameters were measured and the organisms found in the sediment samples were identified up to the class taxonomic level. The highest temperatures (89°C) were recorded within the hydrothermal influence area, which was reflected in an inverse relationship with pH, conductivity and salinity. Sediment temperature profiles increased at greater depth. A total of 371 individuals were found and these were grouped into eight classes: Malacostraca, Maxillopoda, Gastropoda, Bivalvia, Scaphopoda, Polychaeta, Leptocardii and Stenolaemata. The Malacostraca class was the most abundant with 240 individuals, while the Scaphopoda was the lowest with 3. The organic matter contents in the sediments were higher in the areas adjacent to the hydrothermal activity. The high temperature of the hydrothermal discharges structures the benthic community since it was the factor that differed most significantly in the study sites, causing lower abundances in the area of hydrothermal influence compared with the more distant areas. Despite the above, it is concluded that the benthic community of the area with hydrothermal activity is part of the community adjacent to this influence, only in lower numbers.
Polish, Portuguese, and Turkish EFL teachers’ perceptions on the use of OER language processing technologies in MALL: A replication study
Authors: Kic-Drgas Joanna , Seferoğlu Gölge , Kılıçkaya Ferit , Pereira Ricardo 
Published: March 2023

AbstractThis study replicates the research conducted by Pérez-Paredes, Ordoñana Guillamón and Aguado Jiménez (2018) on language teachers’ perceptions on the use of OER language processing technologies in mobile-assisted language learning. It expands the initial research study by adding Polish, Portuguese, and Turkish educational contexts, surveying 239 English as a foreign language teachers in these three countries. The main findings indicate that there are several differences among the three countries, including institutional support regarding the use of mobile devices and the training provided to the teachers. Based on the data collected in these countries, it was found that mobile devices are mainly used for teaching and learning on online platforms. Smartphones were one of the most used devices in English language teaching, while computer labs at schools seem to have lost their popularity. Regarding the technologies available, the results of the study reveal that the participants are most familiar with online dictionaries, spell checkers, and online collocation dictionaries, and the participants’ qualifications are linked to certain differences in familiarity and use of technologies in the classroom. Variables such as gender, age, and years of experience do not show any difference in the familiarity or frequency of use of those technologies. The main findings of the study point out the importance of institutional support and training regarding the use of mobile devices and open educational resources, which are no longer a choice but a necessity in education.
Apparently Seasonal Variations of the Seawater Sr/Ca Ratio Across the Florida Keys Reef Tract
Authors: Khare Agraj , Hughes Hunter P. , Schijf Johan , Kilbourne K. Halimeda 
Published: March 2023

AbstractA 4‐year time‐series of surface seawater Sr/Ca ratios was assembled across a section of the Florida Keys Reef Tract, in order to uncover any variability that might explain previously reported anomalies in regional calibrations of the coral aragonite Sr/Ca paleotemperature proxy. Samples were collected semiannually on a grid of 54 sites, from September of 2016 until January of 2020. The 325‐km2 grid extended from the ocean shore to the forereef wall and from the east end of Long Key to the west end of Marathon. A novel ICP‐AES method was used to measure the Sr/Ca ratio, with ratio calibration and normalization against an in‐house seawater reference, yielding a long‐term precision of better than 0.2%. Significant variations (2%–3%) of the seawater Sr/Ca ratio were found. While it was relatively constant offshore, near the coast the ratio alternated seasonally between higher and lower values, generally resulting in seaward Sr/Ca gradients that were markedly negative in summer but reversed in winter. Inshore seawater Sr/Ca ratios ranged from a summer high of 8.83 mmol/mol to a winter low of 8.54 mmol/mol, the difference corresponding to a potential bias of ∼5.5°C in terms of the coral Sr/Ca paleotemperature proxy. This seasonal variation should diminish the slope of empirical Sr/Ca–SST calibration lines, as has indeed been observed in prior studies with local coral species. Open ocean samples obtained from the Atlantic, Indian, and Pacific enlarge the published Sr/Ca data set for surface seawater and show a much smaller variability of 8.646 ± 0.018 mmol/mol (0.2%).
Therapy-related MDS dissected based on primary disease and treatment—a nationwide perspective
Authors: Moreno Berggren Daniel , Garelius Hege , Willner Hjelm Petter , Nilsson Lars , Rasmussen Bengt , Weibull Caroline E. , Lambe Mats , Lehmann Sören , Hellström-Lindberg Eva , Jädersten Martin , Ejerblad Elisabeth 
Published: March 2023

AbstractIn this population-based study, we aimed to characterize and compare subgroups of therapy-related Myelodysplastic syndromes (t-MDS) and define the implications of type of previous treatment and primary disease. We combined data from MDS patients, diagnosed between 2009 and 2017 (n = 2705), in the nationwide Swedish MDS register, with several health registers. Furthermore, using matched population controls, we investigated the prevalence of antecedent malignancies in MDS patients in comparison with the general population. This first ever nationwide study on t-MDS confirms a shorter median survival for t-MDS compared to de novo MDS (15.8 months vs 31.1 months, p < 0.001). T-MDS patients previously treated with radiation only had disease characteristics with a striking resemblance to de novo-MDS, in sharp contrast to patients treated with chemotherapy who had a significantly higher risk profile. IPSS-R and the WHO classification differentiated t-MDS into different risk groups. As compared with controls, MDS patients had a six-fold increased prevalence of a previous hematological malignancy but only a 34% increased prevalence of a previous solid tumor. T-MDS patients with a previous hematological malignancy had a dismal prognosis, due both to mortality related to their primary disease and to high-risk MDS.
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
Authors: de Jesus Adriana A. , Chen Guibin , Yang Dan , Brdicka Tomas , Ruth Natasha M. , Bennin David , Cebecauerova Dita , Malcova Hana , Freeman Helen , Martin Neil , Svojgr Karel , Passo Murray H. , Bhuyan Farzana , Alehashemi Sara , Rastegar Andre T. , Uss Katsiaryna , Kardava Lela , Marrero Bernadette , Duric Iris , Omoyinmi Ebun , Peldova Petra , Lee Chyi-Chia Richard , Kleiner David E. , Hadigan Colleen M. , Hewitt Stephen M. , Pittaluga Stefania , Carmona-Rivera Carmelo , Calvo Katherine R. , Shah Nirali , Balascakova Miroslava , Fink Danielle L. , Kotalova Radana , Parackova Zuzana , Peterkova Lucie , Kuzilkova Daniela , Campr Vit , Sramkova Lucie , Biancotto Angelique , Brooks Stephen R. , Manes Cameron , Meffre Eric , Harper Rebecca L. , Kuehn Hyesun , Kaplan Mariana J. , Brogan Paul , Rosenzweig Sergio D. , Merchant Melinda , Deng Zuoming , Huttenlocher Anna , Moir Susan L. , Kuhns Douglas B. , Boehm Manfred , Skvarova Kramarzova Karolina , Goldbach-Mansky Raphaela 
Published: March 2023

AbstractNeutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation. Two patients developed liver fibrosis in their first year of life. Next-generation sequencing identified two de novo truncating variants in the Src-family tyrosine kinase,LYN, p.Y508*, p.Q507* and a de novo missense variant, p.Y508F, that result in constitutive activation of Lyn kinase. Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). Treatment with TNF inhibition improved systemic inflammation; and liver fibrosis resolved on treatment with the Src kinase inhibitor dasatinib. Our findings reveal a critical role for Lyn kinase in modulating inflammatory signals, regulating microvascular permeability and neutrophil recruitment, and in promoting hepatic fibrosis.
The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice
Authors: Frontera Jimena L. , Sala Romain W. , Georgescu Ioana A. , Baba Aissa Hind , d’Almeida Marion N. , Popa Daniela , Léna Clément 
Published: March 2023

AbstractFear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.
Sea level rise from West Antarctic mass loss significantly modified by large snowfall anomalies
Authors: Davison Benjamin J. , Hogg Anna E. , Rigby Richard , Veldhuijsen Sanne , van Wessem Jan Melchior , van den Broeke Michiel R. , Holland Paul R. , Selley Heather L. , Dutrieux Pierre 
Published: March 2023

AbstractMass loss from the West Antarctic Ice Sheet is dominated by glaciers draining into the Amundsen Sea Embayment (ASE), yet the impact of anomalous precipitation on the mass balance of the ASE is poorly known. Here we present a 25-year (1996–2021) record of ASE input-output mass balance and evaluate how two periods of anomalous precipitation affected its sea level contribution. Since 1996, the ASE has lost 3331 ± 424 Gt ice, contributing 9.2 ± 1.2 mm to global sea level. Overall, surface mass balance anomalies contributed little (7.7%) to total mass loss; however, two anomalous precipitation events had larger, albeit short-lived, impacts on rates of mass change. During 2009–2013, persistently low snowfall led to an additional 51 ± 4 Gt yr−1 mass loss in those years (contributing positively to the total loss of 195 ± 4 Gt yr−1). Contrastingly, extreme precipitation in the winters of 2019 and 2020 decreased mass loss by 60 ± 16 Gt yr−1 during those years (contributing negatively to the total loss of 107 ± 15 Gt yr−1). These results emphasise the important impact of extreme snowfall variability on the short-term sea level contribution from West Antarctica.
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
Authors: Weisser Nina E. , Sanches Mario , Escobar-Cabrera Eric , O’Toole Jason , Whalen Elizabeth , Chan Peter W. Y. , Wickman Grant , Abraham Libin , Choi Kate , Harbourne Bryant , Samiotakis Antonios , Rojas Andrea Hernández , Volkers Gesa , Wong Jodi , Atkinson Claire E. , Baardsnes Jason , Worrall Liam J. , Browman Duncan , Smith Emma E. , Baichoo Priya , Cheng Chi Wing , Guedia Joy , Kang Sohyeong , Mukhopadhyay Abhishek , Newhook Lisa , Ohrn Anders , Raghunatha Prajwal , Zago-Schmitt Matteo , Schrag Joseph D. , Smith Joel , Zwierzchowski Patricia , Scurll Joshua M. , Fung Vincent , Black Sonia , Strynadka Natalie C. J. , Gold Michael R. , Presta Leonard G. , Ng Gordon , Dixit Surjit 
Published: March 2023

AbstractHuman epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that plays an oncogenic role in breast, gastric and other solid tumors. However, anti-HER2 therapies are only currently approved for the treatment of breast and gastric/gastric esophageal junction cancers and treatment resistance remains a problem. Here, we engineer an anti-HER2 IgG1 bispecific, biparatopic antibody (Ab), zanidatamab, with unique and enhanced functionalities compared to both trastuzumab and the combination of trastuzumab plus pertuzumab (tras + pert). Zanidatamab binds adjacent HER2 molecules in trans and initiates distinct HER2 reorganization, as shown by polarized cell surface HER2 caps and large HER2 clusters, not observed with trastuzumab or tras + pert. Moreover, zanidatamab, but not trastuzumab nor tras + pert, elicit potent complement-dependent cytotoxicity (CDC) against high HER2-expressing tumor cells in vitro. Zanidatamab also mediates HER2 internalization and downregulation, inhibition of both cell signaling and tumor growth, antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP), and also shows superior in vivo antitumor activity compared to tras + pert in a HER2-expressing xenograft model. Collectively, we show that zanidatamab has multiple and distinct mechanisms of action derived from the structural effects of biparatopic HER2 engagement.
Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice
Authors: Lee Young Hee , Kim Yu-Been , Kim Kyu Sik , Jang Mirae , Song Ha Young , Jung Sang-Ho , Ha Dong-Soo , Park Joon Seok , Lee Jaegeon , Kim Kyung Min , Cheon Deok-Hyeon , Baek Inhyeok , Shin Min-Gi , Lee Eun Jeong , Kim Sang Jeong , Choi Hyung Jin 
Published: March 2023

AbstractFor survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet which subpopulation drives food seeking and consummatory behaviours have not been fully addressed. Here, in male mice, fibre photometry recordings demonstrated that LH leptin receptor (LepR) neurons are correlated explicitly in both voluntary seeking and consummatory behaviours. Further, micro-endoscope recording of the LHLepR neurons demonstrated that one subpopulation is time-locked to seeking behaviours and the other subpopulation time-locked to consummatory behaviours. Seeking or consummatory phase specific paradigm revealed that activation of LHLepR neurons promotes seeking or consummatory behaviours and inhibition of LHLepR neurons reduces consummatory behaviours. The activity of LHLepR neurons was increased via Neuropeptide Y (NPY) which acted as a tonic permissive gate signal. Our results identify neural populations that mediate seeking and consummatory behaviours and may lead to therapeutic targets for maladaptive food seeking and consummatory behaviours.