bluuebunny/crossref_metadata_2025_split huggingface dataset:
The differences in virus shedding time between the Delta variant and original SARS-CoV-2 infected patients
Authors: Li Fanglin , Deng Jiayi , Xie Canbin , Wang Guyi , Xu Min , Wu Chenfang , Li Jinxiu , Zhong Yanjun 
Published: July 2023

BackgroundThe worldwide epidemic of Coronavirus Disease 2019 (COVID-19) has evolved into multiple variants. The Delta variant is known for its ability to spread and replicate, while data are limited about the virus shedding time in patients infected by the Delta variant.Methods56 Delta variant and 56 original SARS-CoV-2 infected patients from Hunan, China, matched according to age and gender divided into two groups and compared the baseline characteristics and laboratory findings with appropriate statistical methods.ResultsPatients infected with the Delta variant had significantly fewer symptoms of fever (p &lt; 0.001), fatigue (p = 0.004), anorexia (p &lt; 0.001), shortness of breath (p = 0.004), diarrhea (p = 0.006), positive pneumonia rate of chest CT (p = 0.019) and chest CT ground glass opacities (p = 0.004) than those of patients with the original SARS-CoV-2. Patients of the Delta variant group had a significantly longer virus shedding time [41.5 (31.5, 46.75) vs. 18.5 (13, 25.75), p &lt; 0.001] compared with the original SARS-CoV-2 group. The correlation analyses between the virus shedding time and clinical or laboratory parameters showed that the virus shedding time was positively related to the viral strain, serum creatinine and creatine kinase isoenzyme, while negatively correlated with lymphocyte count, total bilirubin and low-density lipoprotein. Finally, the viral strain and lymphocyte count were thought of as the independent risk factors of the virus shedding time demonstrated by multiple linear regression.ConclusionCOVID-19 patients infected with the Delta variant exhibited fewer gastrointestinal symptoms and prolonged virus shedding time than those infected with the original SARS-CoV-2. Delta variant and fewer lymphocyte were correlated with prolonged virus shedding time.
Visualization of the recurrent laryngeal nerve alone versus intraoperative nerve monitoring in primary thyroidectomy: a framework approach to a missing typology
Authors: Papagoras Dimitris , Tzikos Georgios , Douridas Gerasimos , Arseniou Polyvios , Panagiotou Dimitrios , Kanara Maria , Papavramidis Theodosios 
Published: July 2023

IntroductionSurgical studies evaluating a device or technology in comparison to an established surgical technique should accurately report all the important components of the surgical technique in order to reduce the risk of intervention bias. In the debate of visualization of the recurrent laryngeal nerve alone (VONA) versus intraoperative nerve monitoring (IONM) during thyroidectomy, surgical technique plays a key role in both strategies. Our aim was to investigate whether the surgical technique was considered as a risk of intervention bias by relevant meta-analyses and reviews and if steps of surgical intervention were described in their included studies.MethodsWe searched PUBMED, CENTRAL—Cochrane library, PROSPERO and GOOGLE for reviews and meta-analyses focusing on the comparison of IONM to VONA in primary open thyroidectomy. Τhen, primary studies were extracted from their reference lists. We developed a typology for surgical technique applied in primary studies and a framework approach for the evaluation of this typology by the meta-analyses and reviews.ResultsTwelve meta-analyses, one review (388,252 nerves at risk), and 84 primary studies (128,720 patients) were included. Five meta-analyses considered the absence of typology regarding the surgical technique as a source of intervention bias; 48 primary studies (57.14%) provided information about at least one item of the typology components and only 1 for all of them.DiscussionSurgical technique of thyroidectomy in terms of a typology is underreported in studies and undervalued by meta-analyses comparing VONA to IONM. This missing typology should be reconsidered in the comparative evaluation of these two strategies.
Comparison of Mitochondrial Genome Sequences between Two Palaemon Species of the Family Palaemonidae (Decapoda: Caridea): Gene Rearrangement and Phylogenetic Implications
Authors: Sun Yuman , Chen Jian , Ye Yingying , Xu Kaida , Li Jiji 
Published: July 2023

To further understand the origin and evolution of Palaemonidae (Decapoda: Caridea), we determined the mitochondrial genome sequence of Palaemon macrodactylus and Palaemon tenuidactylus. The entire mitochondrial genome sequences of these two Palaemon species encompassed 37 typical genes, including 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (rRNAs), and 22 transfer RNA genes (tRNAs), and a control region (CR). The lengths of their mitochondrial genomes were 15,744 bp (P. macrodactylus) and 15,735 bp (P. tenuidactylus), respectively. We analyzed their genomic features and structural functions. In comparison with the ancestral Decapoda, these two newly sequenced Palaemon species exhibited a translocation event, where the gene order was trnK-trnD instead of trnD-trnK. Based on phylogenetic analysis constructed from 13 PCGs, the 12 families from Caridea can be divided into four major clades. Furthermore, it was revealed that Alpheidae and Palaemonidae formed sister groups, supporting the monophyly of various families within Caridea. These findings highlight the significant gene rearrangements within Palaemonidae and provide valuable evidence for the phylogenetic relationships within Caridea.
Genome-Wide Identification and Expression Profiling of the NCED Gene Family in Cold Stress Response of Prunus mume Siebold & Zucc
Authors: Chen Ke , Li Xue , Guo Xiaoyu , Yang Lichen , Qiu Like , Liu Weichao , Wang Jia , Zheng Tangchun 
Published: July 2023

The 9-cis-epoxy carotenoid dioxygenase (NCED) is an enzyme that is crucial in abscisic acid (ABA) biosynthesis, and its role is vital in plant development and abiotic stress. However, the function of the NCED family in Rosaceae plant species remains unclear. Through genome-wide screening, we identified 10, 10, 11, 12 and 13 NCED genes in Prunus mume, Prunus apricot, Prunus salicina, Prunus persica, and Rosa chinensis, respectively. Phylogenetic analysis showed that these NCED genes were divided into six groups. Gene structure analysis showed that the number and size of introns were relatively constant in each subfamily, while the motif composition differed significantly among them. Collinearity analysis revealed a high homology of NCEDs in the Prunus genus. Promoter cis-acting element analysis showed that eight PmNCEDs contained abscisic acid-responsive elements (ABRE). Furthermore, expression profile analysis based on qRT-PCR revealed that PmNCED3, PmNCED8 and PmNCED9 were up-regulated in response to low temperature stress, suggesting their significant role in the plant’s response to cold stress. These findings provide insights into the structure and evolution of PmNCEDs and lay the foundation for further studies regarding their function during cold stress.
Analisis Faktor Yang Berhubungan Dengan Perencanaan Keluarga Berencana Sebagai Pencegahan Penularan HIV/AIDS Pada Ibu Hamil
Authors: Susanti Susanti , Nugroho Ikhwan Wahyu 
Published: July 2023

ABSTRAKSalah satu upaya untuk menurunkan angka kematian ibu (AKI) dan menekan angka pertumbuhan penduduk yakni melalui program Keluarga Berencana (KB). Selain menjadi upaya menurunkan AKI metode kontrasepsi juga menjadi salah satu upaya pencegahan penularan HIV dari ibu ke Anak (PPIA). Pada ibu hamil HIV merupakan ancaman bagi keselamatan jiwa ibu dan ancaman bagi anak yang dikandungnya karena bisa terjadi penularan HIV dari ibu ke bayinya. Tujuan menganalisis Faktor Yang Berhubungan Dengan Perencanaan Keluarga Berencana Sebagai Pencegahan Penularan HIV/AIDS Pada Ibu Hamil di Wilayah Puskesmas Cilacap Selatan. Penelitian menggunakan deskriptif analitik dengan pendekatan cross sectional dengan sampel dalam penelitian ini adalah 45 ibu hamil yang periksa di Wilayah Puskesmas Cilacap Selatan I yang memenuhi kriteria inklusi. Hasil penelitian tidak terdapat hubungan antara usia, paritas, tingkat pengetahuan dan sikap dengan perencanaan metode kontrasepsi sebagai pencegahan penularan HIV/AIDS pada ibu Hhmil di Wilayah Puskesmas Cilacap Selatan dengan nilai p > 0.05. Kata Kunci : HIV/AIDS; Metode Kontrasepsi; Ibu Hamil ABSTRACT One of the efforts to reduce the maternal mortality rate (MMR) and reduce the population growth rate is through the Family Planning program. Apart from being an effort to reduce MMR, the contraceptive method is also an effort to prevent HIV transmission from mother to child. In pregnant women HIV is a threat to the safety of the mother's soul and a threat to the child she is carrying because HIV transmission can occur from mother to baby. The aim of this study was to analyse factors related to family planning as a prevention of HIV/AIDS transmission in pregnant women in the South Cilacap Health Center area. The research used descriptive analytic with a cross-sectional approach with the sample in this study were 45 pregnant women who checked in the Cilacap Selatan I Community Health Center area who met the inclusion criteria. The results of the study found no relationship between age, parity, level of knowledge and attitudes with planning contraceptive methods as prevention of HIV/AIDS transmission in Hhmil women in the South Cilacap Health Center area with a p value > 0.05. Keywords: HIV/AIDS; Contraceptive Methods; Pregnant mother
Community Pharmacists’ Perspectives toward Continuing Professional Development: A Qualitative Study
Authors: Hjazeen Rima 
Published: July 2023

Objectives: This study's principal aim was to investigate community pharmacists' views of continuing professional development (CPD) and to explore pharmacists' perceptions of the most common facilitators and barriers to participation in continuing education (CE).
Methods: A series of seven focus group sessions were undertaken with groups of four to seven community pharmacists. Focus group transcripts were thematically analyzed using a qualitative data analysis method.
Results: Four key themes were identified: (1) community pharmacists' attitudes toward CPD; (2) perceived motivating factors for CPD; (3) experienced barriers to CPD; (4) and potential strategies for improving pharmacists' CPD.
Conclusion: Practicing pharmacists need support now, and changes to undergraduate education are warranted to keep abreast of current developments and changes to practice. Despite limitations, the distinctive nature of this study would have a valuable contribution to the field of professional development. It can inform theory, policy, and practice relating to pharmacists' CPD at both a professional level and governmentally, helping the relevant parties make informed decisions.
CoolMomentum mitigating local minima in variational quantum eigensolvers
Authors: Tsukayama Daisuke , Shirakashi Jun-ichi , Imai Hiroshi 
Published: July 2023

Abstract
We compare the use of adaptive moment estimation (ADAM), simultaneous perturbation stochastic approximation (SPSA), Nakanishi–Fujii–Todo method (NFT), and CoolMomentum in a variational quantum eigensolver. Using a random weighted max-cut problem, we numerically analyze these methods and confirm that CoolMomentum performs better than the other methods. ADAM and SPSA tend to get trapped in local minima or exhibit infeasible optimization durations. Although NFT exhibits fast convergence, it tends to suffer from local minima similar to ADAM and SPSA. Contrarily, CoolMomentum shows a higher accuracy under noiseless and realistic hardware noise conditions.
Influence of substrate sapphire orientation on direct CVD growth of graphene
Authors: Kawai Yoshikazu , Nakao Takuto , Oda Takato , Ohtani Noboru , Hibino Hiroki 
Published: July 2023

Abstract
Graphene is grown directly on c-, a-, m-, and r-plane sapphire substrates by CVD, and their structures and electrical properties are compared. The obtained graphene is always polycrystalline, but the grain size is dependent on the sapphire surface orientation. The largest and smallest grains respectively appear on the m- and c-planes, and the graphene grown on the a- and r-planes has intermediate grain sizes. The carrier mobility is the largest for the graphene grown on the m-plane, indicating that the grain boundaries make a significant impact on the carrier transport as scattering centers. Nevertheless, the RT Hall effect mobility measured for the mm-sized m-plane samples reaches 7000 cm2 V−1 s−1. m-plane sapphire is promising as an insulating substrate for direct graphene growth.
Analysis of resist images with pattern defects by Hough transform
Authors: Jin Yuqing , Kozawa Takahiro , Aoki Kota , Nakamura Tomoya , Makihara Yasushi , Yagi Yasushi 
Published: July 2023

Abstract
EUV technology has led to smaller device features, emphasizing the importance of minimizing defects in production. Research has focused on improving resist material uniformity to address variability in resulting patterns caused by stochastic factors, with attention paid to the underlying chemistry. In this study, we developed an automated method for analyzing resist patterns with defects using image recognition techniques. This method involves the analysis of line-and-space resist patterns using image processing technologies, comparison using established standards, and the identification of patterns with defects. A modified version of Hough transform technique was employed to automatically analyze approximately 2500 scanning electron microscopy images. Using our method, we can identify defective and deformed patterns by comparing the detected line-and-space resist patterns with the established standard. The indices that characterize the resist patterns with defects are proposed. Finally, simulated images were also used to uncover the chemical information underlying defective resist patterns.
Crítica e Ontologia no Tractatus. Algumas observações a partir de “A essência da proposição e a essência do mundo”, de L. H. Lopes dos Santos.
Authors: Carvalho Marcelo 
Published: July 2023

Resumo:Este artigo discute a leitura que faz o estudo introdutório de Luiz Henrique Lopes dos Santos (1992) dos aforismos iniciais do Tractatus. Tal leitura vê, nesses aforismos iniciais, as consequências ontológicas de um argumento transcendental cuja premissa é a concepção de figuração desenvolvida nos aforismos subsequentes. Em contraste com essa leitura, aqui é defendido que se possa entender esses aforismos iniciais como uma investigação de toda normatividade, explicitando o vínculo entre necessidade e totalidade. Assim se aponta para uma nova perspectiva de interpretação do Tractatus e de seus vínculos com a tradição crítica. Abstract:This article discusses the reading made in the introductory study by Luiz Henrique Lopes dos Santos (1992) of the initial aphorisms of the Tractatus. Such a reading holds, in these initial aphorisms, the ontological consequences of a transcendental argument whose premise is the conception of picturing developed in the subsequent aphorisms. In contrast to this reading, it is argued here that these initial aphorisms can be understood as an investigation of all normativity, making explicit the link between necessity and totality. Thus, the present paper points out to a new perspective of interpretation of the Tractatus and its links with the critical tradition.
High-Performance Hand Kinematics Estimation Requires Full Bandwidth High-Density EMG Recordings
Authors: Sîmpetru Raul , Cnejevici Vlad , Farina Dario , Vecchio Alessandro Del 
Published: July 2023

<p>Surface electromyography (sEMG) is a non-invasive technique that records the electrical signals generated by muscles through electrodes placed on the skin. sEMG is the state-of-the-art method used to control active upper limb prostheses because of the association between its amplitude and the neural drive sent from the spinal cord to muscles. However, accurately estimating the kinematics of a freely moving human hand using sEMG from extrinsic hand muscles remains a challenge. Deep learning has been recently successfully applied to this problem by mapping raw sEMG signals into kinematics. Nonetheless, the optimal number of EMG signals and the type of pre-processing that would maximize performance have not been investigated yet. Here, we analyze the impact of these factors on the accuracy in kinematics estimates. For this purpose, we processed monopolar sEMG signals that were originally recorded from 320 electrodes over the forearm muscles of 13 subjects. We used a previously published deep learning method that can map the kinematics of the human hand with real-time resolution. While state-of-the-art myocontrol algorithms essentially use the temporal envelope of the EMG signal as the only EMG feature, we show that our approach requires the full bandwidth of the signal in the temporal domain for accurate estimates. Spatial filtering had a smaller impact and low-order spatial filters may be suitable. Moreover, reducing the number of channels by ablation resulted in large performance losses. The highest accuracy was reached with the highest number of available sensors (320). Importantly and unexpected, our results also showed that increasing the number of channels above those used in this study may further enhance the accuracy in predicting the kinematics of the human hand. We conclude that full bandwidth high-density EMG systems of hundreds of electrodes are needed for accurate kinematic estimates of the human hand.</p>
PERSEPSI CALON GURU ANAK USIA DINI MENGENAI KONSEP BILANGAN 1-10
Authors: Widayati Sri , Siswono Tataq , Wiryanto Wiryanto , Suryanti Suryanti , Jatmiko Budi 
Published: July 2023

<p>Konsep bilangan adalah salah satu materi Matematika yang harus dipahami dan dikuasai oleh setiap manusia. Memiliki penguasaan yang kuat pada konsep bilangan 1-10 akan berdampak terutama pada materi selanjutnya, yaitu Aritmatika serta pada materi Matematika lainnya. Penelitian kuantitatif deskriptif ini dilakukan melalui survey dengan cara menyebarkan lewat g-form. Tujuan penelitian ini untuk mengetahui data awal persepsi 170 calon guru anak usia dini di Universitas Negeri Surabaya mengenai konsep bilangan 1-10 pada anak usia dini. Hasil menunjukkan bahwa lebih dari lima puluh persen persepsi calon guru anak usia dini di Universitas Negeri Surabaya cara mengajarkan konsep bilangan 1-10 adalah dengan mengenalkan anak pada simbol bilangan 1-10 terlebih dahulu, cara mengajarkan berhitung pada anak usia dini dengan menggunakan gambar sebanyak sembilan puluh lima persen responden, mengenalkan simbol angka merupakan kegiatan pertama kali yang dikenalkan pada anak ketika masuk PAUD/ TK sebanyak tujuh puluh tiga persen, dan mengenalkan konsep penjumlahan dan pengurangan pada anak usia dini yang tepat adalah dengan cara langsung menggunakan simbol angka (operasi hitung) sebanyak enam puluh satu persen. </p>
The Effectiveness of Combination Therapy of Needling and Secretome from Mesenchymal Stem Cells (Serum 10%) for Acne Scar Treatment
Authors: Tan Sukmawati Tansil , Yohanes Firmansyah  , William Gilbert Satyanegara  , Edwin Destra  , Giovanno Sebastian Yogie  , Catharina Sagita Moniaga  
Published: July 2023

Background: Acne scars can have various impacts on individuals, both physical and psychological. Acne scars arise as a result of complications from acne vulgaris. This study purposed to determine the effectiveness of the treatment using a combination of SC-PWJMSC with microneedling for acne scars.
Methods: Pre-post clinical trial involving patients with acne scar. The intervention used in this study was a combination therapy of microneedling and secretome from mesenchymal stem cells. The intervention was carried out 1 time and monitored for 42 days. Primary outcome in the form of Observer visual scar assessment scale (OVSAS) was assessed at baseline and 42nd day, Secondary outcome (regenerative parameters) was assessed at baseline, 21st day and 42nd day.
Results: There was a significant change in the primary and secondary outcomes (p-value <0.001) without any significant side effects.
Conclusion: This study showed that combining needing with secretome from mesenchymal stem cells (MSCs) led to satisfactory results in repairing acne scars and in a number of other ways (secondary outcomes). On the other hand, there are limitations in this study in the form of no comparison therapy for the treatment of acne scar.
Detection of mutations and fusions in lung adenocarcinoma using ion torrent sequenc-ing technology
Authors: STRATAN Valentina , TUTUIANU Valeri , SITNIC Victor , PREPELITA Corneliu , POPA Cristina , BILBA Valeriu , BRENISTER Sergiu 
Published: July 2023

Introduction. Adenocarcinomas are the most common lung tumors and are often diagnosed in advanced stages when the tumor has a polyclonal form with a wide variety of genetic alterations and activated mutational processes. Comprehensive analysis of mutational status from FFPE tissue samples in such patients can provide a therapeutic perspective and contribute considerably to clinical decisions thereby increasing the overall survival rate.
Material and methods. 22 genes were analyzed for mutations and 4 genes for fusion transcripts using two Ion AmpliSeq panels. DNA was isolated from paraffin-embedded tissue sections while RNA analysis was performed using two types of samples: paraffin blocks and fresh tumor tissue. Key variant detection and data analysis was performed using next platforms: Ion Reporter, ONCOMINE, R language.
Results. The study of 30 tumor samples allowed the detection of 147 mutations and 4 fusions in 19 genes, and the therapeutically actionable variants were associated with different drugs clinically approved or in the phase of clinical trials. The most genetic variants were identified in the TP53, EGFR and NOTCH1 genes with a prevalence of over 50% in the TP53 gene, while all 4 detected fusions (one fusion per sample) represent the association of the ALK gene with other partners: EML4(13)-ALK(20) – present in 2 samples; EML4(6)-ALK(20); and an ALK fusion with an unknown partner gene.
Conclusions. Analyzing the mutational status of tumor samples from patients with lung adenocarcinoma it has been ascertained the therapeutic utility of gene panel sequencing covering point mutations, INDELs and SNVs, as well as gene fusions, using FFPE tissue as primary material. This is valid for both targeted monotherapies and combined therapies.
Lectotypifications in Meliosma (Sabiaceae)
Authors: Morales J. Francisco 
Published: July 2023

As part of the treatment of Meliosma (Sabiaceae) for Flora Mesoamericana, four lectotypes are selected for Lorenzanea dentata var. minor Liebm., L. ira Liebm., L. grandifolia Liebm., and L. vernicosa Liebm., and four second-step lectotypifications are performed for Lorenzanea dentata Liebm., L. glabrata Liebm., Meliosma donnellsmithii Urb., and M. tonduzii Donn.Sm.