bluuebunny/crossref_metadata_2025_split huggingface dataset:
The History of the Cytoplasmic Elements during Vitellogenesis in Drosophila melanogaster
Authors: HSU W. SIANG 
Published: September 2023

ABSTRACT
At least two kinds of yolk are developed in the eggs of Drosophila melanogaster. The origin of the proteid yolk has been traced to precursors sent into the oocyte by the nurse cells, while the minute fatty yolk granules are transformed chondriomites also contributed by the nurses. The behaviour and morphology of Golgi material in the nurses indicate that it may be responsible for a third type of yolk. A yolk nucleus has been found in oocytes of an age when the germinal disk has been pushed to one side. So long as such a structure exists, all the proteid yolk precursors are concentrated and matured within its confine. Soon this structure disintegrates and disappears. But after its disappearance, yolk precursors continue to be sent by the nurses into the oocyte, and there they develop into mature granules apparently without the benefit of a yolk nucleus. On the basis of facts thus far obtained, it is, therefore, difficult to say just what role the so-called yolk nucleus plays in vitellogenesis in Drosophila melanogaster. Golgi material in the nurse cells has been observed to undergo two distinct proliferations. In young nurses, Golgi material occurs in a few discrete bits which, as the nurses grow in size, proliferate into a large number of intertwining threads so arranged as to suggest a net. Then follows a period in which only very few minute granules of Golgi material can be seen. This is definitely a period of scarcity. After this, a second proliferation takes place. This one is carried to such an extreme extent that the cytoplasm of the cells is just black with Golgi material. The Golgi threads, arranged more or less in a parallel fashion and very closely together, present the appearance of pieces of Golgi ‘tissue’. Next, the pieces of ‘tissue’ loosen up into separate threads from which individual Golgi granules arise. These granules enlarge to become vesicles. In the course of development of the nurse cells, the mitochondria also undergo a proliferation. Finally, the chondrioconts break up into granules which enlarge and eventually all transform into droplets of unsaturated fat. My observations point to the conclusion that the oocyte depends upon its nurses for the production of fatty yolk. Proteid yolk granules, however, are developed within the oocyte, though from precursors sent in also by the nurse cells. The follicular cells do not appear to contribute anything to vitellogenesis in Drosophila. An idiosome-like granule has been observed in oogonia, and also in oocytes up to a certain stage of development. For reasons stated elsewhere, it cannot be regarded as an idiosome nor as a centrosome. This structure has not been observed in nurse cells.
Assessing the awareness regarding lung cancer and attitude toward screening practice: Protocol for a cross-sectional study from Wardha District
Authors: Ajankar Vaishnavi V. , Mude Gaurav 
Published: September 2023

Background:Due to a lack of knowledge about risk factors and symptoms lung cancer is often found at later stages. A total of 19.3 million new cancer cases were recorded last year and resulted in nearly 10 million fatalities. The aim of this study is to evaluate the level of awareness among the general population about lung cancer, its risk factor, symptoms, and available screening methods, as well as to assess the attitude toward screening practice for early detection among a common population in the Wardha district.Protocol:This study focuses on assessing the level of awareness of lung cancer in Wardha district. It is an observational cross-sectional study design that will be conducted using a standardized questionnaire. The study aims to recruit 400 subjects, both male and female, aged between 18 and 65 years old, from various communities. The participant should be capable of providing informed consent and responding to the survey question. Age, sex, educational level, occupation this are the variable. Participants will be randomly selected from different communities in Wardha district. A structured questionnaire will be administered to collect data on awareness, attitudes, knowledge, and other relevant variables. Chi-squared test will be used to explore associations between awareness, attitudes, and demographic variables (e.g., age, sex, education).Conclusions:It is hoped that this study will encourage people to participate in screening programs in order to detect cancer at early stages and lead to better treatment outcomes.
Case Report: Implication of antiangiogenic therapy (bevacizumab) along with dichloroacetate therapy on endometriosis patient seeking infertility treatment
Authors: Mehakar Saurabh , More Akash , Dutta Shilpa , Jadhav Ritesh , Chaudhari Namrata , Shaikh Rukaiya 
Published: September 2023

Endometriosis is a pervasive gynecological ailment which usually results in unease and infertility and is signified by an accumulation of endometrial-like tissue outside the uterus. Current endometriosis medications, which often entail surgical intervention and hormone therapy, are geared around easing discomfort as well as improving fertility. However, alternative approaches targeting angiogenesis have shown promise in managing endometriosis-associated infertility. This case report highlights the implications of combining antiangiogenic therapy (bevacizumab) with dichloroacetate (DCA) therapy in a patient with endometriosis seeking infertility treatment. A 34-year-old woman presented with a five-year history of severe pelvic pain and primary infertility due to stage IV endometriosis. The patient sought other possibilities after repeated unsuccessful attempts using assisted reproductive technology. A revolutionary therapy strategy combining bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, and DCA, a metabolic modulator, has been proposed considering the potential significance of angiogenesis in endometriosis-related infertility. The patient underwent a six-month treatment regimen consisting of intravenous bevacizumab infusions combined with oral DCA administration. The theory behind this combination was to target the metabolic reprogramming typically associated with the disease in addition to altering the abnormal angiogenic signaling pathways that contribute to the pathogenesis of endometriosis. Given the scores on the visual analogue scale, the patient's pelvic pain substantially decreased during the time frame of treatment. Additionally, a notable improvement in ovarian reserve markers was observed, including an increase in anti-Müllerian hormone levels and the number of antral follicles. This case report suggests that the combination of bevacizumab and DCA may have a synergistic effect in managing endometriosis-associated infertility. This form of therapy may provide patients who have failed typical infertility treatment options with an innovative therapeutic approach since it targets both angiogenesis and metabolic changes.
Improving health outcomes among older adults in India: effectiveness and implementability of a novel comprehensive geriatric assessment based intervention
Authors: Kshatri Jaya Singh , Shenkin Susan , Mercer Stewart , Weller David , Palo Subrata Kumar , Pati Sandipana , Janssen Daisy , Pati Sanghamitra 
Published: September 2023

Background: There is significant evidence on the benefits of comprehensive assessment in older adults. But this evidence is primarily from western countries and in secondary care settings. National policies in India recognize this need and envision community-based screening and facility-based assessment programs integrated into the care pathways for the elderly. However, this is yet to translate into specific interventions, primarily due to lack of complex interventions necessary and evidence of their effectiveness. This study aims to design and pilot an integrated (Community + Facility) Elderly Health Status Assessment and Screening (EHSAS) intervention to improve health outcomes of older adults and assess its feasibility for implementation in Indian rural settings. Methods: We propose a hybrid design where we will build the complex intervention, develop and validate the tools needed, pilot it using an exploratory cluster randomized trial and evaluate its implementatbility using the Exploration-Preparation-Implementation-Sustainment (EPIS) framework. Conclusions: This study will fill critical gaps in evidence regarding the effectiveness of geriatric screening and assessment in community and primary care settings in low-middle income countries and provide validated tools and implementation models for adoption into national programs. Registration: CTRI/2023/07/055661
Association of Sweet's syndrome and Behçet's disease: is it possible? A case report
Authors: El idrissi El houcine , El aissat El mehdi , Assoufi Naoufal , Tbouda Mohamed 
Published: September 2023

Introduction: Behçet's disease is a systemic vasculitis characterized by a large clinical polymorphism with a particular frequency of cutaneous signs. Sweet's syndrome is a neutrophilic dermatosis marked by the sudden appearance of painful skin lesions in the form of erythematous papules, nodules or plaques. This syndrome is associated with high fever, neutrophilia and histologically a diffuse infiltrate of neutrophils in the dermis. Observation: We report the case of a 43-year-old patient followed for Behçet's disease, who developed cutaneous plaques of neutrophilic dermatosis of both upper limbs. The clinical and biological picture was in favor of Sweet's syndrome. Conclusion: The coexistence of Sweet's syndrome and Behçet's disease is already reported in the literature. The association is however very rare given the differences in the clinical and pathogenic features between the two conditions.
Switchable polarization-independent THz reflector/absorber
Authors: Yan Mengyao , Liu QiKun , Zhou Dongfang , Wang Ziyue 
Published: September 2023

This paper introduces a novel metamaterial switchable terahertz (THz) reflector/absorber, which incorporates a composite graphene and vanadium dioxide (VO2) structure. The structure comprises gold and graphene layers separated by VO2 dielectric layers. By leveraging the electrical adjustability of graphene and the temperature adjustability of VO2, the operating frequency and absorption amplitude of the absorption spectrum can be controlled by adjusting the Fermi levels of graphene and the conductivity of VO2. The designed dual-function switch can be utilized as a reflector when VO2 exhibits a metallic state and as a perfect multiband absorber when VO2 exhibits dielectric properties. Numerical simulation results demonstrate that the proposed device exhibits exceptional performance for TE and TM waves, achieving a more than 99% absorption rate at 2.2, 6.5, and 10.5 THz. This structure holds considerable potential for a wide range of applications, including temperature monitoring, stealth technology, wireless communication, and biomedicine.
DIY House Shows and Music Venues in the US: Ethnographic Explorations of Place and Community, David Verbuč (2022)
Authors: Dines Mike 
Published: September 2023

Review of: DIY House Shows and Music Venues in the US: Ethnographic Explorations of Place and Community, David Verbuč (2022)
London: Routledge, 270 pp.,
ISBN 978-1-03204-917-5, h/bk, £130
You Are Beautiful and You Are Alone: The Biography of Nico, Jennifer Otter Bickerdike (2022)
Authors: Hollins Paul 
Published: September 2023

Review of: You Are Beautiful and You Are Alone: The Biography of Nico, Jennifer Otter Bickerdike (2022)
London: Faber and Faber, 393 pp.,
ISBN 978-0-57135-001-8, h/bk, £20
Optimization of biogas potential using kinetic models, response surface methodology, and instrumental evidence for biodegradation of tannery fleshings during anaerobic digestion
Authors: V. Kavan Kumar , Mahendiran R. , Subramanian P. , Karthikeyan S. , Surendrakumar A. , Kumargouda V. , Y. Ravi , Choudhary Sharda , Singh Ravindra , Verma Arvind K. 
Published: September 2023

Abstract
The optimization of the batch size experiment was run for a hydraulic retention time of 45 days using proteolytic enzyme pretreatment. The highest amounts of biogas were produced in comparison to conventional BDS (25:75), which is not processed with enzymes, and there was an increase in the biogas generation of 13.9 and 18.57%. The kinetic models show the goodness of fit between 0.993 and 0.998 and the correlation coefficient’s value domain was [−1, 1] from a statistical perspective. The Box–Behnken design was carried out using the response surface methodology at different levels of independent parameters to optimize the process. Different instruments were evaluated to determine the chemical structure change and the contamination of the different treatments and the raw sample of tannery fleshings was determined. Thermogravimetric analysis was conducted to determine the loss of weight on thermal degradation. The Fourier transform infrared spectrometry was carried out to determine the different functional groups, such as –OH, –CH, –NH, and C–O, present in the samples of tannery fleshings. Scanning electron microscopy and energy dispersive X-ray analysis were carried out to determine the morphological alterations in the substrate, digestate, enzyme-pretreated fleshings, and the chemical composition of samples.
華語「知道類」近義詞之習得順序
Authors: 品嬅 吳 , 陳 純音 , 惠玲 賴  
Published: September 2023

提要
本文比較「知道類」心理動詞「知道」、「懂」、「了解」、「明白」差異, 並探討華語二語學習者的習得順序與偏誤。首先採取 Huang 等人 (2000) 的「動詞語意表達模式」 (Module-Attribute Representation of Verbal Semantics, MARVS), 分析四個心理動詞語意屬性、搭配類型與句法功能後, 邀請 16 位華語母語人士及 16 位華語為第二語言的外籍學生完成「知道類」近義詞測驗。研究發現, 四個心理動詞按成績由高至低依序為「知道」、「懂」、「了解」、「明白」, 符合訊息處理難易度。在偏誤部分, 「明白」的偏誤最多, 就常誤用為「知道」。此外, 「懂」與「了解」意思相近, 常出現相互誤代情形。
Quality assurance programs for vitamin A and E in serum: are we doing enough to assess laboratory performance?
Authors: Fitzpatrick Michael , Andersen Trisha , Bush Jonathan , Greaves Ronda F. , Woollard Gerald , Hoad Kirsten , Collie Jake T.B. , Browning Sarah , Harrower Tamantha , Graham Peter , Punyalack Wilson 
Published: September 2023

Abstract

Objectives
Monitoring serum vitamin A (retinol) and vitamin E (α-tocopherol) concentrations is common practice for assessing nutritional status. Measurement of these vitamins can be challenging due to several factors. Whilst the RCPAQAP Vitamins: Serum Program assists participating laboratories in harmonisation, the materials provided do not contain the analogues of retinol and α-tocopherol that may be present in real patient samples. We aimed to assess participants’ capacity to accurately report retinol and α-tocopherol in the presence of the vitamin E analogues tocopherol acetate and γ-tocopherol.

Methods
A supplementary series of a control sample and three matched spiked samples were distributed to each laboratory participating in the Program. Retinol and α-tocopherol results for each spiked sample were compared to the results of the control sample submitted by each participant. Acceptability of retinol and α-tocopherol results was determined based on the RCPAQAP allowable performance specifications (APS).

Results
Thirteen participants returned results for the supplementary sample series. Interference from α-tocopherol acetate was observed with results below the APS in 30 % (n=4) of laboratories for retinol quantification and in 23 % (n=3) for α-tocopherol quantification. One laboratory returned results above the APS for α-tocopherol when γ-tocopherol was present.

Conclusions
This supplementary sample series has shown that the presence of vitamin E analogues can lead to the over or under estimation of nutritional status by some participants. Affected laboratories are encouraged to review their analytical procedures. To further assess laboratory competence, EQA providers should consider using patient samples or spiked challenge samples.
Impact of climatic disturbances on the chemical compositions and metabolites of Salvia officinalis
Authors: Laftouhi Abdelouahid , Eloutassi Noureddine , Ech-Chihbi Elhachmia , Kara Mohammed , Assouguem Amine , Ali Essam A. , Fidan Hafize , Rais Zakia , Taleb Abdslam , Beniken Mustapha , Taleb Mustapha 
Published: September 2023

Abstract
Aromatic and medicinal plants in ecosystems are subject to various climatic disturbances that impact their morphological and physiological processes. Although plants have mechanisms to adapt to their climatic conditions, such as periods of drought and lack of precipitation, their metabolism is still affected. This study aimed to predict and evaluate the behavior of Salvia officinalis under climatic disturbances. Over a period of 4 years in a controlled environment, three treatments were applied to the plant: Treatment 1 with normal monthly average temperature and precipitation in the first year; Treatment 2 with a temperature increase of 5°C and a 50% reduction in water supply in the second year; and Treatment 3 with a temperature increase of 10°C and a 75% reduction in water supply in the fourth year. The results show that the percentage of primary metabolites, including nutritional values, changed with increasing temperature and decreasing precipitation. Treatment 1 had 7.13% protein, 6.21% carbohydrate, 1.35% lipid, and 4% dietary fiber, while Treatment 2 had 7.05% protein, 5.12% carbohydrate, 1.01% lipid, and 3.01% dietary fiber, and Treatment 3 had 6.86% protein, 3.02% carbohydrate, 0.52% lipid, and 2.34% dietary fiber. The mineral composition of the plant also changed with each treatment, with Mg decreasing from 10.02 to 8.55 to 0.05%, Fe decreasing from 8.18 to 8 to 7.62%, K decreasing from 5.55 to 5.05 to 4.02%, Mn decreasing from 5.54 to 5.11 to 3.48%, Ca decreasing from 4.65 to 2.75 to 1.23%, and P decreasing from 3.37 to 3.05 to 2.25%. Regarding secondary metabolites, the percentage of alkaloids, flavonoids, saponins, coumarins, tannins, and essential oil yield changed as well. Treatment 2 showed an increase in secondary metabolites, while Treatment 3 showed a decrease. Alkaloids increased from 9.56 to 13.68 to 11.3%, flavonoids increased from 7.53 to 13.48 to 10.49%, saponins increased from 5.23 to 7.44 to 6%, coumarins increased from 3.35 to 4.85 to 3.99%, tannins increased from 2.26 to 3.22 to 2.62%, and essential oil yield increased from 0.53 to 0.80 to 0.62%. Gas chromatography analysis revealed that the major compounds of the essential oils of Salvia officinalis, such as α-thujone, manool, β-caryophyllene, α-humulene, viridiflorol, 1,8-cineol, and camphor, were also modified by temperature and water stress.
Vibrational comfort improvement for a passenger car driver seat
Authors: Akçay Serhat , Şefkat Gürsel 
Published: September 2023

Abstract
This paper presents an experimental study aimed at providing new insights into passenger vehicle driver seat vibration. The study investigates the effects of various driver seat components on the damping coefficient. By employing a design for six sigma method, an optimized seating solution is proposed to enhance seat comfort levels. The control factors used in this study include seat cushion upholstery, topper foam, cushion foam, pulmaflex, torsion bar and seat structure. Seat position, foam thickness and body mass are considered as potential noise factors. Subjective evaluation of seat comfort is conducted using the SAE J 1441-2016, comparing three different passenger car driver seats. The seats are disassembled from the vehicles and mounted on a six-degree-of-freedom shaker test bench. Vertical vibration data are filtered, and transmissibility curves are experimentally obtained from the seat rail to the seat cushion via a pad. Uncomfortable seat prototypes are then manufactured, and alternative configurations are tested on the shaker. The objective and subjective evaluations of the seat prototypes reveal that lower foam hardness, higher foam density, and flexible upholstery contribute to improved comfort levels. Moreover, the prototype seat with optimum parameters receives a subjective evaluation SAE score of +0.75, indicating an enhancement in comfort.
The crystal structure of poly[bis(μ
2−3−aminopyridine−4−carboxylato−κ
2
N:O)Zinc(II)], [Zn(C6H5N2O2)2]
n
Authors: Liu Fang-Fang , Ping Zhao-Yan , Zhou Wei-Wei , Zhao Wang 
Published: September 2023

Abstract
[Zn

(

C
6

H
5

N
2

O
2

)

2

${({\mathrm{C}}_{6}{\mathrm{H}}_{5}{\mathrm{N}}_{2}{\mathrm{O}}_{2})}_{2}$

]
n
, orthorhombic, P212121 (no. 19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å3, Z = 4, R

gt
(F) = 0.0391, wR

ref
(F
2) = 0.0710, T = 296 K.
Understanding visual processing of motion: completing the picture using experimentally driven computational models of MT
Authors: Zarei Eskikand Parvin , Grayden David B. , Kameneva Tatiana , Burkitt Anthony N. , Ibbotson Michael R. 
Published: September 2023

Abstract
Computational modeling helps neuroscientists to integrate and explain experimental data obtained through neurophysiological and anatomical studies, thus providing a mechanism by which we can better understand and predict the principles of neural computation. Computational modeling of the neuronal pathways of the visual cortex has been successful in developing theories of biological motion processing. This review describes a range of computational models that have been inspired by neurophysiological experiments. Theories of local motion integration and pattern motion processing are presented, together with suggested neurophysiological experiments designed to test those hypotheses.
The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity
Authors: Venkatasubramani Anuroop Venkateswaran , Ichinose Toshiharu , Kanno Mai , Forne Ignasi , Tanimoto Hiromu , Peleg Shahaf , Imhof Axel 
Published: September 2023

AbstractProteins involved in cellular metabolism and molecular regulation can extend lifespan of various organisms in the laboratory. However, any improvement in aging would only provide an evolutionary benefit if the organisms were able to survive under non‐ideal conditions. We have previously shown that Drosophila melanogaster carrying a loss‐of‐function allele of the acetyltransferase chameau (chm) has an increased healthy lifespan when fed ad libitum. Here, we show that loss of chm and reduction in its activity results in a substantial reduction in weight and a decrease in starvation resistance. This phenotype is caused by failure to properly regulate the genes and proteins required for energy storage and expenditure. The previously observed increase in survival time thus comes with the inability to prepare for and cope with nutrient stress. As the ability to survive in environments with restricted food availability is likely a stronger evolutionary driver than the ability to live a long life, chm is still present in the organism's genome despite its apparent negative effect on lifespan.
Diferentes perspectivas sobre os conflitos político-religiosos do Império Romano Tardio: os olhares de Amiano Marcelino e Paulo Orósio (séculos IV e V)
Authors: De Almeida Rodrigues Thaís , Picoli Sotocorno Ana Carolina 
Published: September 2023

A Antiguidade Tardia é um período abundante em conflitos político-religiosos, incluindo disputas e alianças de poder cujo equilíbrio estava em constante transformação. O cenário tardo-antigo reúne rivalidades religiosas entre os cristianismos, os judaísmos e as religiões politeístas, disputas de território internas e com os povos bárbaros, competições pelo poder imperial, entre outros fatores que tornam esse período tão único. Dentro desse panorama abrangente, concentramos nossa análise nas perspectivas de Amiano Marcelino, autor advindo da região oriental e seguidor do politeísmo, e Paulo Orósio, de origem ibérica e defensor do cristianismo niceno. Para isso, utilizaremos suas obras principais: Res Gestae (380 - 390), escrita por Amiano, e Historiae Adversus Paganos (416 - 417), escrita por Orósio, produções que revelam como seus contextos particulares influenciaram na interpretação dos eventos descritos.