bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease
Authors: Lee Solhwi , Lee Kunhee , Bae Hyeonjin , Lee Kyungmin , Lee Junghwa , Ma Junhui , Lee Ye Ji , Lee Bo Ryeong , Park Woong-Yang , Im Se Jin 
Published: September 2023

AbstractGraft-versus-host disease (GvHD) is a severe complication of hematopoietic stem cell transplantation driven by activated allogeneic T cells. Here, we identify a distinct subset of T cell factor-1 (TCF1)+ CD8+ T cells in mouse allogeneic and xenogeneic transplant models of acute GvHD. These TCF1+ cells exhibit distinct characteristics compared to TCF1- cells, including lower expression of inhibitory receptors and higher expression of costimulatory molecules. Notably, the TCF1+ subset displays exclusive proliferative potential and could differentiate into TCF1- effector cells upon antigenic stimulation. Pathway analyses support the role of TCF1+ and TCF1- subsets as resource cells and effector cells, respectively. Furthermore, the TCF1+ CD8+ T cell subset is primarily present in the spleen and exhibits a resident phenotype. These findings provide insight into the differentiation of allogeneic and xenogeneic CD8+ T cells and have implications for the development of immunotherapeutic strategies targeting acute GvHD.
A chemical catalyst enabling histone acylation with endogenous acyl-CoA
Authors: Habazaki Misuzu , Mizumoto Shinsuke , Kajino Hidetoshi , Kujirai Tomoya , Kurumizaka Hitoshi , Kawashima Shigehiro A. , Yamatsugu Kenzo , Kanai Motomu 
Published: September 2023

AbstractLife emerges from a network of biomolecules and chemical reactions catalyzed by enzymes. As enzyme abnormalities are often connected to various diseases, a chemical catalyst promoting physiologically important intracellular reactions in place of malfunctional endogenous enzymes would have great utility in understanding and treating diseases. However, research into such small-molecule chemical enzyme surrogates remains limited, due to difficulties in developing a reactive catalyst capable of activating inert cellular metabolites present at low concentrations. Herein, we report a small-molecule catalyst, mBnA, as a surrogate for a histone acetyltransferase. A hydroxamic acid moiety of suitable electronic characteristics at the catalytic site, paired with a thiol-thioester exchange process, enables mBnA to activate endogenous acyl-CoAs present in low concentrations and promote histone lysine acylations in living cells without the addition of exogenous acyl donors. An enzyme surrogate utilizing cellular metabolites will be a unique tool for elucidation of and synthetic intervention in the chemistry of life and disease.
Microbial growth under drought is confined to distinct taxa and modified by potential future climate conditions
Authors: Metze Dennis , Schnecker Jörg , Canarini Alberto , Fuchslueger Lucia , Koch Benjamin J. , Stone Bram W. , Hungate Bruce A. , Hausmann Bela , Schmidt Hannes , Schaumberger Andreas , Bahn Michael , Kaiser Christina , Richter Andreas 
Published: September 2023

AbstractClimate change increases the frequency and intensity of drought events, affecting soil functions including carbon sequestration and nutrient cycling, which are driven by growing microorganisms. Yet we know little about microbial responses to drought due to methodological limitations. Here, we estimate microbial growth rates in montane grassland soils exposed to ambient conditions, drought, and potential future climate conditions (i.e., soils exposed to 6 years of elevated temperatures and elevated CO2 levels). For this purpose, we combined 18O-water vapor equilibration with quantitative stable isotope probing (termed ‘vapor-qSIP’) to measure taxon-specific microbial growth in dry soils. In our experiments, drought caused >90% of bacterial and archaeal taxa to stop dividing and reduced the growth rates of persisting ones. Under drought, growing taxa accounted for only 4% of the total community as compared to 35% in the controls. Drought-tolerant communities were dominated by specialized members of the Actinobacteriota, particularly the genus Streptomyces. Six years of pre-exposure to future climate conditions (3 °C warming and + 300 ppm atmospheric CO2) alleviated drought effects on microbial growth, through more drought-tolerant taxa across major phyla, accounting for 9% of the total community. Our results provide insights into the response of active microbes to drought today and in a future climate, and highlight the importance of studying drought in combination with future climate conditions to capture interactive effects and improve predictions of future soil-climate feedbacks.
River interlinking alters land-atmosphere feedback and changes the Indian summer monsoon
Authors: Chauhan Tejasvi , Devanand Anjana , Roxy Mathew Koll , Ashok Karumuri , Ghosh Subimal 
Published: September 2023

AbstractMassive river interlinking projects are proposed to offset observed increasing droughts and floods in India, the most populated country in the world. These projects involve water transfer from surplus to deficit river basins through reservoirs and canals without an in-depth understanding of the hydro-meteorological consequences. Here, we use causal delineation techniques, a coupled regional climate model, and multiple reanalysis datasets, and show that land-atmosphere feedbacks generate causal pathways between river basins in India. We further find that increased irrigation from the transferred water reduces mean rainfall in September by up to 12% in already water-stressed regions of India. We observe more drying in La Niña years compared to El Niño years. Reduced September precipitation can dry rivers post-monsoon, augmenting water stress across the country and rendering interlinking dysfunctional. Our findings highlight the need for model-guided impact assessment studies of large-scale hydrological projects across the globe.
Automated Construction of a Photocatalysis Dataset for Water-Splitting Applications
Authors: Isazawa Taketomo , Cole Jacqueline M. 
Published: September 2023

AbstractWe present an automatically generated dataset of 15,755 records that were extracted from 47,357 papers. These records contain water-splitting activity in the presence of certain photocatalysts, along with additional information about the chemical reaction conditions under which this activity was recorded. These conditions include any co-catalysts and additives that were present during water splitting, the length of time for which the photocatalytic experiment was conducted, and the type of light source used, including its wavelength. Despite the text extraction of such a wide range of chemical reaction attributes, the dataset afforded good precision (71.2%) and recall (36.3%). These figures-of-merit were calculated based on a random sample of open-access papers from the corpus. Mining such a complex set of attributes required the development of novel techniques in knowledge extraction and interdependency resolution, leveraging inter- and intra-sentence relations, which are also described in this paper. We present a new version (version 2.2) of the chemistry-aware text-mining toolkit ChemDataExtractor, in which these new techniques are included.
A WAV file dataset of bottlenose dolphin whistles, clicks, and pulse sounds during trawling interactions
Authors: Di Nardo Francesco , De Marco Rocco , Lucchetti Alessandro , Scaradozzi David 
Published: September 2023

AbstractGlobally, interactions between fishing activities and dolphins are cause for concern due to their negative effects on both mammals and fishermen. The recording of acoustic emissions could aid in detecting the presence of dolphins in close proximity to fishing gear, elucidating their behavior, and guiding potential management measures designed to limit this harmful phenomenon. This data descriptor presents a dataset of acoustic recordings (WAV files) collected during interactions between common bottlenose dolphins (Tursiops truncatus) and fishing activities in the Adriatic Sea. This dataset is distinguished by the high complexity of its repertoire, which includes various different typologies of dolphin emission. Specifically, a group of free-ranging dolphins was found to emit frequency-modulated whistles, echolocation clicks, and burst pulse signals, including feeding buzzes. An analysis of signal quality based on the signal-to-noise ratio was conducted to validate the dataset. The signal digital files and corresponding features make this dataset suitable for studying dolphin behavior in order to gain a deeper understanding of their communication and interaction with fishing gear (trawl).
Modulation of cigarette smoke induced alterations by aqueous Ocimum sanctum leaf extract in pulmonary tissue of rodents
Authors: Ranawat Pavitra , Kaur Navdeep , Koul Ashwani 
Published: September 2023

AbstractSmoking has been associated with an increased risk of asthma, lung cancer, cardiovascular diseases, chronic bronchitis, and a massive amount of oxidative stress. The present study was undertaken to determine the modulatory effects of Holi Basil/Tulsi, (Ocimum sanctum) leaf extract on cigarette smoke-induced pulmonary damage in mice. Cigarette smoke (CS) inhalation increased the levels of pulmonary lipid peroxidation, and reactive oxygen species and decreased the levels of glutathione. Histoarchitectural alterations and enhanced tissue lactate dehydrogenase (LDH) activity in pulmonary tissue was distinctly indicative of damage. Enhanced mucin production was also observed through mucicarmine and Alcian Blue-Periodic Acid Schiff (PAS) staining. Increased expression of MUC5AC was also observed. Alterations in the lung were also evident through FTIR studies. Administration of Ocimum sanctum leaf extract (80 mg/kg b.w) to CS exposed mice ameliorated these alterations to a greater extent. These findings are suggestive of the fact that Ocimum sanctum leaf extract effectively modulated CS-induced deleterious effects on pulmonary tissue.
AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater
Authors: Sessa Lucia , Diana Rosita , Gentile Francesco Silvio , Mazzaglia Fabio , Panunzi Barbara 
Published: September 2023

AbstractMonitorable AIE polymers with a bioactive pattern are employed in advanced biomedical applications such as functional coatings, theranostic probes, and implants. After the global COVID-19 pandemic, interest in developing surfaces with superior antimicrobial, antiproliferative, and antiviral activities dramatically increased. Many formulations for biocide surfaces are based on hybrid organic/inorganic materials. Palladium (II) complexes display relevant activity against common bacteria, even higher when compared to their uncoordinated ligands. This article reports the design and synthesis of two series of orthopalladated polymers obtained by grafting a cyclopalladated fragment on two different O, N chelating Schiff base polymers. Different grafting percentages were examined and compared for each organic polymer. The fluorescence emission in the solid state was explored on organic matrixes and grafted polymers. DFT analysis provided a rationale for the role of the coordination core. The antibacterial response of the two series of hybrid polymers was tested against the total coliform group of untreated urban wastewater, revealing excellent inactivation ability.
Cost-effectiveness analysis of COVID-19 variants effects in an age-structured model
Authors: Cho Giphil , Kim Young Jin , Seo Sang-hyup , Jang Geunsoo , Lee Hyojung 
Published: September 2023

AbstractThis study analyzes the impact of COVID-19 variants on cost-effectiveness across age groups, considering vaccination efforts and nonpharmaceutical interventions in Republic of Korea. We aim to assess the costs needed to reduce COVID-19 cases and deaths using age-structured model. The proposed age-structured model analyzes COVID-19 transmission dynamics, evaluates vaccination effectiveness, and assesses the impact of the Delta and Omicron variants. The model is fitted using data from the Republic of Korea between February 2021 and November 2022. The cost-effectiveness of interventions, medical costs, and the cost of death for different age groups are evaluated through analysis. The impact of different variants on cases and deaths is also analyzed, with the Omicron variant increasing transmission rates and decreasing case-fatality rates compared to the Delta variant. The cost of interventions and deaths is higher for older age groups during both outbreaks, with the Omicron outbreak resulting in a higher overall cost due to increased medical costs and interventions. This analysis shows that the daily cost per person for both the Delta and Omicron variants falls within a similar range of approximately $10–$35. This highlights the importance of conducting cost-effect analyses when evaluating the impact of COVID-19 variants.
Satellites capture socioeconomic disruptions during the 2022 full-scale war in Ukraine
Authors: Ialongo Iolanda , Bun Rostyslav , Hakkarainen Janne , Virta Henrik , Oda Tomohiro 
Published: September 2023

AbstractSince February 2022, the full-scale war in Ukraine has been strongly affecting society and economy in Ukraine and beyond. Satellite observations are crucial tools to objectively monitor and assess the impacts of the war. We combine satellite-based tropospheric nitrogen dioxide (NO2) and carbon dioxide (CO2) observations to detect and characterize changes in human activities, as both are linked to fossil fuel combustion processes. We show significantly reduced NO2 levels over the major Ukrainian cities, power plants and industrial areas: the NO2 concentrations in the second quarter of 2022 were 15–46% lower than the same quarter during the reference period 2018–2021, which is well below the typical year-to-year variability (5–15%). In the Ukrainian capital Kyiv, the NO2 tropospheric column monthly average in April 2022 was almost 60% smaller than 2019 and 2021, and about 40% smaller than 2020 (the period mostly affected by the COVID-19 restrictions). Such a decrease is consistent with the essential reduction in population and corresponding emissions from the transport and commercial/residential sectors over the major Ukrainian cities. The NO2 reductions observed in the industrial regions of eastern Ukraine reflect the decline in the Ukrainian industrial production during the war (40–50% lower than in 2021), especially from the metallurgic and chemical industry, which also led to a decrease in power demand and corresponding electricity production by thermal power plants (which was 35% lower in 2022 compared to 2021). Satellite observations of land properties and thermal anomalies indicate an anomalous distribution of fire detections along the front line, which are attributable to shelling or other intentional fires, rather than the typical homogeneously distributed fires related to crop harvesting. The results provide timely insights into the impacts of the ongoing war on the Ukrainian society and illustrate how the synergic use of satellite observations from multiple platforms can be useful in monitoring significant societal changes. Satellite-based observations can mitigate the lack of monitoring capability during war and conflicts and enable the fast assessment of sudden changes in air pollutants and other relevant parameters.
Observation of photonic Peierls transition for manipulating microwave in metallic diaphragm-array periodic structures
Authors: Wu Chia Ho , Liu Chengyang , Lin Xianqing , Wang Wei , Guo Yi Chun , Wang Zhuoyuan , Ye Guoqiang , He Fang , Ni Donghua , Wang Xiaolong , Shen Linfang , Shen Jianqi , Cai Zhengbing , Chen Gang 
Published: September 2023

AbstractPeierls transition that modifies electronic band structure has attracted intensive attention in solid state physics. In the present work, we report that a photonic analog of Peierls transition has been observed in a 1-D triangular metal diaphragm array, where the photonic bandgap structures have been designed at will by adjusting periodically metal diaphragm positions. It is shown by the numerical analysis that the transmission and radiation effect of the present periodic metal structure designed through the Peierls transition rule exhibits the behavior significantly different from an original periodic structure with each unit cell containing a metal diaphragm. The near- and far-field measurement results are in good agreement with our theoretical simulation. The present effect of photonic Peierls transition can serve as a working mechanism for designing new types of guided wave devices. It can be seen that the photonic Peierls transition would be one of the simplest ways for modifying the transport characteristics of electromagnetic waves in periodic structures.
Autoencoder-based multimodal prediction of non-small cell lung cancer survival
Authors: Ellen Jacob G. , Jacob Etai , Nikolaou Nikos , Markuzon Natasha 
Published: September 2023

AbstractThe ability to accurately predict non-small cell lung cancer (NSCLC) patient survival is crucial for informing physician decision-making, and the increasing availability of multi-omics data offers the promise of enhancing prognosis predictions. We present a multimodal integration approach that leverages microRNA, mRNA, DNA methylation, long non-coding RNA (lncRNA) and clinical data to predict NSCLC survival and identify patient subtypes, utilizing denoising autoencoders for data compression and integration. Survival performance for patients with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) was compared across modality combinations and data integration methods. Using The Cancer Genome Atlas data, our results demonstrate that survival prediction models combining multiple modalities outperform single modality models. The highest performance was achieved with a combination of only two modalities, lncRNA and clinical, at concordance indices (C-indices) of 0.69 ± 0.03 for LUAD and 0.62 ± 0.03 for LUSC. Models utilizing all five modalities achieved mean C-indices of 0.67 ± 0.04 and 0.63 ± 0.02 for LUAD and LUSC, respectively, while the best individual modality performance reached C-indices of 0.64 ± 0.03 for LUAD and 0.59 ± 0.03 for LUSC. Analysis of biological differences revealed two distinct survival subtypes with over 900 differentially expressed transcripts.
Built environment microbiomes transition from outdoor to human-associated communities after construction and commissioning
Authors: Young Gregory R. , Sherry Angela , Smith Darren L. 
Published: September 2023

AbstractThe microbiota of the built environment is linked to usage, materials and, perhaps most importantly, human health. Many studies have attempted to identify ways of modulating microbial communities within built environments to promote health. None have explored how these complex communities assemble initially, following construction of new built environments. This study used high-throughput targeted sequencing approaches to explore bacterial community acquisition and development throughout the construction of a new build. Microbial sampling spanned from site identification, through the construction process to commissioning and use. Following commissioning of the building, bacterial richness and diversity were significantly reduced (P < 0.001) and community structure was altered (R2 = 0.14; P = 0.001). Greater longitudinal community stability was observed in outdoor environments than indoor environments. Community flux in indoor environments was associated with human interventions driving environmental selection, which increased 10.4% in indoor environments following commissioning. Increased environmental selection coincided with a 12% reduction in outdoor community influence on indoor microbiomes (P = 2.00 × 10–15). Indoor communities became significantly enriched with human associated genera includingEscherichia,Pseudomonas, andKlebsiellaspp. These data represent the first to characterize the initial assembly of bacterial communities in built environments and will inform future studies aiming to modulate built environment microbiota.
Phase encoded quantum key distribution up to 380 km in standard telecom grade fiber enabled by baseline error optimization
Authors: Pathak Nishant Kumar , Chaudhary Sumit , Sangeeta  , Kanseri Bhaskar 
Published: September 2023

AbstractPhase encoding in quantum key distribution (QKD) enables long-distance information-theoretic secure communication in optical fibers. We present a novel theoretical model characterizing errors from various sources in practical phase encoding-based QKD systems, namely the laser linewidth, detector dark counts, and channel dispersion. This model provides optimized optical pulse parameters and less distortion in pulses, which eliminates system imperfections and leads to a reduced quantum bit error rate (QBER) for practical QKD scenario. This analysis is applicable to various fiber-based phase and time encoding protocols. In particular, we implement this to a differential phase shift (DPS) QKD scheme operating at a 2.5 GHz clock, which produces a secure key rate of 193 bits/s at a fiber length of 265 km and an unprecedented QBER < 1$$\%$$
%
up to 225 km length with standard telecom components. We show that by adjusting the quantum efficiency and dark count rates of detectors, proposed system can establish secure keys up to 380 km distance using standard telecom grade fiber with a QBER of 1.48%. Moreover, the system is compatible with existing optical fiber networks and capable of establishing a secure key exchange between two cities 432 km apart using ultra-low-loss (ULL) specialty fiber.
Autonomic dysregulation in long-term patients suffering from Post-COVID-19 Syndrome assessed by heart rate variability
Authors: Mooren Frank C. , Böckelmann Irina , Waranski Melina , Kotewitsch Mona , Teschler Marc , Schäfer Hendrik , Schmitz Boris 
Published: September 2023

AbstractPost-COVID-19 Syndrome (PCS) is a condition with multiple symptoms partly related to dysregulation of the autonomic nerve system. Assessment of heart rate variability (HRV) using 24 h Holter-ECG may serve as a surrogate to characterize cardiac autonomic activity. A prospective study including 103 PCS patients (time after infection = 252 days, age = 49.0 ± 11.3 years, 45.7% women) was performed and patients underwent detailed clinical screening, cardiopulmonary exercise testing, and 24 h Holter monitoring. Data of PCS patients was compared to 103 CAD patients and a healthy control group (n = 90). After correction for age and sex, frequency-related variables differed in PCS patients compared to controls including LF/HFpower, LF/HFnu, and LF/HF ratio (24 h; p ≤ 0.001). By contrast, these variables were largely comparable between PCS and CAD patients, while sympathetic activation was highest in PCS patients during the 24 h period. Overall, PCS patients showed disturbed diurnal adjustment of HRV, with impaired parasympathetic activity at night. Patients hospitalized during acute infection showed an even more pronounced overactivation of sympathetic activity compared to patients who underwent ambulant care. Our data demonstrate persistent HRV alterations in PCS patients with long-term symptom duration, suggesting a sustained impairment of sympathovagal balance. Moreover, sympathetic overstimulation and diminished parasympathetic response in long-term PCS patients are comparable to findings in CAD patients. Whether HRV variables have a prognostic value in PCS and/or might serve as biomarkers indicating a successful interventional approach warrants further longitudinal studies.