bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Academic Intelligence: Increasing College Success for Students on the Autism Spectrum
Authors: Wenzel Christine , Brown Jane Thierfeld 
Published: August 2023

AbstractStudents on the autism spectrum are attending colleges and universities in vastly increasing numbers. Though these students are typically very bright and academically capable of succeeding in higher education, achieving success in college goes far beyond academics. Being a college student, especially on a residential campus, requires many other life and social skills, as well as a certain degree of independence and self‐motivation; therefore, it is essential that students choose a college that has programs, services, and resources appropriate for their needs.
Deep learning‐based detection and classification of multi‐leaf collimator modeling errors in volumetric modulated radiation therapy
Authors: Nakamura Sae , Sakai Madoka , Ishizaka Natsuki , Mayumi Kazuki , Kinoshita Tomotaka , Akamatsu Shinya , Nishikata Takayuki , Tanabe Shunpei , Nakano Hisashi , Tanabe Satoshi , Takizawa Takeshi , Yamada Takumi , Sakai Hironori , Kaidu Motoki , Sasamoto Ryuta , Ishikawa Hiroyuki , Utsunomiya Satoru 
Published: August 2023

AbstractPurposeThe purpose of this study was to create and evaluate deep learning‐based models to detect and classify errors of multi‐leaf collimator (MLC) modeling parameters in volumetric modulated radiation therapy (VMAT), namely the transmission factor (TF) and the dosimetric leaf gap (DLG).MethodsA total of 33 clinical VMAT plans for prostate and head‐and‐neck cancer were used, assuming a cylindrical and homogeneous phantom, and error plans were created by altering the original value of the TF and the DLG by ± 10, 20, and 30% in the treatment planning system (TPS). The Gaussian filters of and 1.0 were applied to the planar dose maps of the error‐free plan to mimic the measurement dose map, and thus dose difference maps between the error‐free and error plans were obtained. We evaluated 3 deep learning‐based models, created to perform the following detections/classifications: (1) error‐free versus TF error, (2) error‐free versus DLG error, and (3) TF versus DLG error. Models to classify the sign of the errors were also created and evaluated. A gamma analysis was performed for comparison.ResultsThe detection and classification of TF and DLG error were feasible for ; however, a considerable reduction of accuracy was observed for depending on the magnitude of error and treatment site. The sign of errors was detectable by the specifically trained models for and 1.0. The gamma analysis could not detect errors.ConclusionsWe demonstrated that the deep learning‐based models could feasibly detect and classify TF and DLG errors in VMAT dose distributions, depending on the magnitude of the error, treatment site, and the degree of mimicked measurement doses.
WiTNNess: An international natural history study of infantile‐onset TNNT1 myopathy
Authors: Strauss Kevin A. , Carson Vincent J. , Bolettieri Emilienne , Everett Mariah , Bollinger Ashton , Bowser Lauren E. , Beiler Keturah , Young Millie , Edvardson Simon , Fraenkel Nitay , D'Amico Adele , Bertini Enrico , Lingappa Lokesh , Chowdhury Devyani , Lowes Linda P. , Iammarino Megan , Alfano Lindsay N. , Brigatti Karlla W. 
Published: August 2023

ABSTRACTObjectiveWe created WiTNNess as a hybrid prospective/cross‐sectional observational study to simulate a clinical trial for infantile‐onset TNNT1 myopathy. Our aims were to identify populations for future trial enrollment, rehearse outcome assessments, specify endpoints, and refine trial logistics.MethodsEligible participants had biallelic pathogenic variants of TNNT1 and infantile‐onset proximal weakness without confounding conditions. The primary endpoint was ventilator‐free survival. “Thriving” was a secondary endpoint defined as the ability to swallow and grow normally without non‐oral feeding support. Endpoints of gross motor function included independent sitting and standing as defined by the Word Health Organization, a novel TNNT1 abbreviated motor score, and video mapping of limb movement. We recorded adverse events, concomitant medications, and indices of organ function to serve as comparators of safety in future trials.ResultsSixteen children were enrolled in the aggregate cohort (6 prospective, 10 cross‐sectional; median census age 2.3 years, range 0.5–13.8). Median ventilator‐free survival was 20.2 months and probability of death or permanent mechanical ventilation was 100% by age 60 months. All six children (100%) in the prospective arm failed to thrive by age 12 months. Only 2 of 16 (13%) children in the aggregate cohort sat independently and none stood alone. Novel exploratory motor assessments also proved informative. Laboratory and imaging data suggest that primary manifestations of TNNT1 deficiency are restricted to skeletal muscle.InterpretationWiTNNess allowed us to streamline and economize the collection of historical control data without compromising scientific rigor, and thereby establish a sound operational framework for future clinical trials.
Recent Advances in the Functionalization of Remote C−H Bonds by Hofmann‐Löffler‐Freytag‐type Reactions
Authors: Teng Xiaoxu , Yu Tingting , Shi Jianwei , Huang Huisheng , Wang Rentian , Peng Wei , Sun Kai , Yang Shubing , Wang Xin 
Published: August 2023

AbstractNitrogen radicals are one of the most useful reactive intermediates for selective transposition via intramolecular hydrogen atom transfer (HAT). The Hofmann‐Löffler‐Freytag (HLF) reaction is a distinctive radical‐based approach in which nitrogen radicals are used for remote C−H bond functionalization via intramolecular HAT. Due to its excellent regioselectivity and atomic economy, the HLF reaction represents a new approach for the preparation of valuable functional molecules. In this review, we provide a brief overview of recent research advances in remote C−H bond functionalization via nitrogen radicals mediated HLF‐type reactions involving intermolecular cyclization, intramolecular cyclization, and remote δ‐site functionalization.
Organocatalytic Vinylogous Michael Addition/Cyclization Cascade of 2‐Alkylidene Indane‐1,3‐diones with Enals: A Regio‐ and Stereocontrolled Diversity‐Oriented Route to Indane‐1,3‐dione Derivatives
Authors: Kuan Jen‐Yu , Chen I‐Ting , Lin Hsuan , Han Jeng‐Liang 
Published: August 2023

AbstractA substrate‐dependent, regio‐ and stereocontrolled diversity‐oriented organocatalytic vinylogous Michael addition/cyclization cascade of 2‐alkylidene indane‐1,3‐diones with enals, using secondary amines as the catalyst, has been developed. This allows the synthesis of spiroindane‐1,3‐diones, tetrahydrofluoren‐9‐one derivatives, and benzofused oxabicyclo[3.3.1]nonanes in a highly selective manner. Plausible catalytic pathways for the formation of these biologically interesting compounds were proposed. Density functional theory (DFT) calculations have clarified and supported the mechanisms how the organocatalyst is able to activate the enals and 2‐hydroxycinnamaldehydes, directing the C−C bond forming with the vinylogous dienolates and enabling the synthesis of these interesting indane‐1,3‐diones derivatives.
Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N‐Glycan Library for Functional Glycomics
Authors: Ma Wenjing , Xu Zhuojia , Jiang Yuhan , Liu Jialin , Xu Dandan , Huang Wei , Li Tiehai 
Published: August 2023

AbstractN‐Glycosylation, a main post‐translational modification of Immunoglobulin G (IgG), plays a significant role in modulating the immune functions of IgG. However, the precise function elucidation of IgG N‐glycosylation remains impeded due to the obstacles in obtaining comprehensive and well‐defined N‐glycans. Here, an easy‐to‐implement divergent approach is described to synthesize a 64‐membered IgG N‐glycan library covering all possible biantennary and bisected N‐glycans by reprogramming biosynthetic assembly lines based on the inherent branch selectivity and substrate specificity of enzymes. The unique binding specificities of 64 N‐glycans with different proteins are deciphered by glycan microarray technology. This unprecedented collection of synthetic IgG N‐glycans can serve as standards for N‐glycan structure identification in complex biological samples and the microarray data enrich N‐glycan glycomics to facilitate biomedical applications.
Interactions with alloparents are associated with the diversity of infant skin and fecal bacterial communities in Chicago, United States
Authors: Manus Melissa B. , Sardaro Maria Luisa Savo , Dada Omolola , Davis Maya I. , Romoff Melissa R. , Torello Stephanie G. , Ubadigbo Esther , Wu Rebecca C. , Miller Emily S. , Amato Katherine R. 
Published: August 2023

AbstractIntroduction: Social interactions shape the infant microbiome by providing opportunities for caregivers to spread bacteria through physical contact. With most research focused on the impact of maternal–infant contact on the infant gut microbiome, it is unclear how alloparents (i.e., caregivers other than the parents) influence the bacterial communities of infant body sites that are frequently contacted during bouts of caregiving, including the skin.Methods: To begin to understand how allocare may influence the diversity of the infant microbiome, detailed questionnaire data on infant–alloparent relationships and specific allocare behaviors were coupled with skin and fecal microbiome samples (four body sites) from 48 infants living in Chicago, United States.Results: Data from 16S rRNA gene amplicon sequencing indicated that infant skin and fecal bacterial diversity showed strong associations (positive and negative) to having female adult alloparents. Alloparental feeding and co‐sleeping displayed stronger associations to infant bacterial diversity compared to playing or holding. The associations with allocare behaviors differed in magnitude and direction across infant body sites. Bacterial relative abundances varied by infant–alloparent relationship and breastfeeding status.Conclusion: This study provides some of the first evidence of an association between allocare and infant skin and fecal bacterial diversity. The results suggest that infants' exposure to bacteria from the social environment may vary based on infant–alloparent relationships and allocare behaviors. Since the microbiome influences immune system development, variation in allocare that impacts the diversity of infant bacterial communities may be an underexplored dimension of the social determinants of health in early life.
Detection of High‐Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins
Authors: Bartley Christopher M. , Ngo Thomas T. , Do Le Duy , Zekeridou Anastasia , Dandekar Ravi , Muñiz‐Castrillo Sergio , Alvarenga Bonny D. , Zorn Kelsey C. , Tubati Asritha , Pinto Anne‐Laurie , Browne Weston D. , Hullett Patrick W. , Terrelonge Mark , Schubert Ryan D. , Piquet Amanda L. , Yang Binxia , Montalvo Mayra , Kung Andrew F. , Mann Sabrina A. , Shah Maulik P. , Geschwind Michael D. , Gelfand Jeffrey M. , DeRisi Joseph L. , Pittock Sean J. , Honnorat Jérôme , Pleasure Samuel J. , Wilson Michael R. 
Published: August 2023

ObjectiveCo‐occurring anti‐tripartite motif‐containing protein 9 and 67 autoantibodies (TRIM9/67‐IgG) have been reported in only a very few cases of paraneoplastic cerebellar syndrome. The value of these biomarkers and the most sensitive methods of TRIM9/67‐IgG detection are not known.MethodsWe performed a retrospective, multicenter study to evaluate the cerebrospinal fluid and serum of candidate TRIM9/67‐IgG cases by tissue‐based immunofluorescence, peptide phage display immunoprecipitation sequencing, overexpression cell‐based assay (CBA), and immunoblot. Cases in which TRIM9/67‐IgG was detected by at least 2 assays were considered TRIM9/67‐IgG positive.ResultsAmong these cases (n = 13), CBA was the most sensitive (100%) and revealed that all cases had TRIM9 and TRIM67 autoantibodies. Of TRIM9/67‐IgG cases with available clinical history, a subacute cerebellar syndrome was the most common presentation (n = 7/10), followed by encephalitis (n = 3/10). Of these 10 patients, 70% had comorbid cancer (7/10), 85% of whom (n = 6/7) had confirmed metastatic disease. All evaluable cancer biopsies expressed TRIM9 protein (n = 5/5), whose expression was elevated in the cancerous regions of the tissue in 4 of 5 cases.InterpretationTRIM9/67‐IgG is a rare but likely high‐risk paraneoplastic biomarker for which CBA appears to be the most sensitive diagnostic assay. ANN NEUROL 2023;94:1086–1101
Dibenzothiophene Sulfone‐Based Ambipolar‐Transporting Blue‐Emissive Organic Semiconductors Towards Simple‐Structured Organic Light‐Emitting Transistors
Authors: Li Qingbin , Zhang Yihan , Lin Junfeng , Zou Ye , Wang Pu , Qin Zhengsheng , Wang Yongshuai , Li Yang , Zhang Yu , Gao Can , Zang Yaping , Hu Wenping , Dong Huanli 
Published: August 2023

AbstractThe development of blue‐emissive ambipolar organic semiconductor is an arduous target due to the large energy gap, but is an indispensable part for electroluminescent device, especially for the transformative display technology of simple‐structured organic light‐emitting transistor (SS‐OLET). Herein, we designed and synthesized two new dibenzothiophene sulfone‐based high mobility blue‐emissive organic semiconductors (DNaDBSOs), which demonstrate superior optical property with solid‐state photoluminescent quantum yield of 46–67 % and typical ambipolar‐transporting properties in SS‐OLETs with symmetric gold electrodes. Comprehensive experimental and theoretical characterizations reveal the natural of ambipolar property for such blue‐emissive DNaDBSOs‐based materials is ascribed to a synergistic effect on lowering LUMO level and reduced electron injection barrier induced by the interfacial dipoles effect on gold electrodes due to the incorporation of appropriate DBSO unit. Finally, efficient electroluminescence properties with high‐quality blue emission (CIE (0.179, 0.119)) and a narrow full‐width at half‐maximum of 48 nm are achieved for DNaDBSO‐based SS‐OLET, showing good spatial control of the recombination zone in conducting channel. This work provides a new avenue for designing ambipolar emissive organic semiconductors by incorporating the synergistic effect of energy level regulation and molecular‐metal interaction, which would advance the development of superior optoelectronic materials and their high‐density integrated optoelectronic devices and circuits.
Electronic Configuration Tuning of Centrally Extended Non‐Fullerene Acceptors Enabling Organic Solar Cells with Efficiency Approaching 19 %
Authors: Duan Tainan , Feng Wanying , Li Yulu , Li Zhixiang , Zhang Zhe , Liang Huazhe , Chen Hongbin , Zhong Cheng , Jeong Seonghun , Yang Changduk , Chen Shanshan , Lu Shirong , Rakitin Oleg A. , Li Chenxi , Wan Xiangjian , Kan Bin , Chen Yongsheng 
Published: August 2023

AbstractIn the molecular optimizations of non‐fullerene acceptors (NFAs), extending the central core can tune the energy levels, reduce nonradiative energy loss, enhance the intramolecular (donor‐acceptor and acceptor‐acceptor) packing, facilitate the charge transport, and improve device performance. In this study, a new strategy was employed to synthesize acceptors featuring conjugation‐extended electron‐deficient cores. Among these, the acceptor CH‐BBQ, embedded with benzobisthiadiazole, exhibited an optimal fibrillar network morphology, enhanced crystallinity, and improved charge generation/transport in blend films, leading to a power conversion efficiency of 18.94 % for CH‐BBQ‐based ternary organic solar cells (OSCs; 18.19 % for binary OSCs) owing to its delicate structure design and electronic configuration tuning. Both experimental and theoretical approaches were used to systematically investigate the influence of the central electron‐deficient core on the properties of the acceptor and device performance. The electron‐deficient core modulation paves a new pathway in the molecular engineering of NFAs, propelling relevant research forward.
Efficient and Direct Functionalization of Allylic sp3 C−H Bonds with Concomitant CO2 Reduction
Authors: Qi Ming‐Yu , Xu Yi‐Jun 
Published: August 2023

AbstractSolar‐driven CO2 reduction integrated with C−C/C−X bond‐forming organic synthesis represents a substantially untapped opportunity to simultaneously tackle carbon neutrality and create an atom‐/redox‐economical chemical synthesis. Herein, we demonstrate the first cooperative photoredox catalysis of efficient and tunable CO2 reduction to syngas, paired with direct alkylation/arylation of unactivated allylic sp3 C−H bonds for accessing allylic C−C products, over SiO2‐supported single Ni atoms‐decorated CdS quantum dots (QDs). Our protocol not only bypasses additional oxidant/reductant and pre‐functionalization of organic substrates, affording a broad of allylic C−C products with moderate to excellent yields, but also produces syngas with tunable CO/H2 ratios (1 : 2–5 : 1). Such win‐win coupling catalysis highlights the high atom‐, step‐ and redox‐economy, and good durability, illuminating the tantalizing possibility of a renewable sunlight‐driven chemical feedstocks manufacturing industry.
Extraction of rosmarinic acid from Salvia officinalis L. using tunable deep eutectic solvent and its physiochemical properties
Authors: Albalushi Alaa , Chua Bee Lin , Ghanem Nader , Ali Ameena , Tee Lee Hong , Wong Wai Yin 
Published: August 2023

AbstractRosmarinic acid (RA) is a phenolic compound known for its remarkable antioxidant, antiallergic, antimicrobial, anticarcinogenic and anti‐inflammatory properties, making it highly valuable for diverse industrial applications such as medicine formulation, cosmetic production and food additives. This study focused on the green extraction of RA and antioxidants from Salvia officinalis L. using deep eutectic solvents (DESs). Various DESs were prepared using choline chloride (ChCl) as the sole hydrogen bond acceptor (HBA) with various hydrogen bond donors (HBDs), including acetic acid (AA), propanoic acid (PA), malonic acid (MA) and ethylene glycol (EG) at different compositions (1:1, 1:2 and 2:1) and water content (0–30%). The resulting clear and homogeneous DESs were characterised by Fourier‐transform infrared (FTIR) analysis, density measurements and Nile red assay to investigate their physicochemical properties. Ultrasound‐assisted extraction was performed with the successfully formed DESs at 70°C for 30 min, using a solid‐solvent ratio of 1:30 g/mL to extract RA and antioxidants from S. officinalis L. leaves. Stable DESs (ChCl‐AA, ChCl‐MA, ChCl‐PA and ChCl‐PG) were formed at the molar ratio of 1:2. The formation of hydrogen bonds in the DESs was confirmed by FTIR spectra (3800–3000 cm−1). The DESs densities decreased with increasing temperature and water content. ChCl‐MA DES was the most polar, with the lowest transition energy,
value of 44.672 kcal mol−1. ChCl‐EG DES extract (1:2 molar ratio, 30% water content) yielded the highest RA (49.619 ppm), which is 12.2% higher than the methanol extract. ChCl‐MA DES extract (1:2 molar ratio, 10% water content) showed 11.57% higher antioxidant activity than methanol extract, with an inhibition percentage of 92.663%. Overall, ChCl‐EG (30% water content) and ChCl‐MA (10% water content) at the molar ratio of 1:2 are viable green alternatives to conventional solvents for extracting RA and antioxidants from S. officinalis L., respectively.
Effect of transverse vortex on performance of wave plate demister
Authors: Yang Laishun , Cui Yi , Wang Zhen , Sun Peipei , Cui Weiwei , Wang Cuiping 
Published: August 2023

AbstractCorrugated plate mist eliminators are commonly employed in industrial processes to eliminate liquid droplets from gas flows. Engineering a mist eliminator with excellent separation performance including high removal efficiency and low pressure drop and is a primary consideration in industrial processes. This study focuses on the separation of tiny droplets reinforced by the generation of transverse vortices with the help of curved wings. The Euler–Lagrange model is developed to predict the behavior of droplets in gas streams, and velocity distributions and particle trajectories on the demisters were derived. And the prediction equations of the curved wing structure sizes on the efficiency and pressure drop of the mist eliminator are established. The results demonstrated that the grade separation efficiency of 10~20 μm droplet was significantly improved by 25.7%~66.51%. Moreover, for the total removal efficiency, it could be improved from .8 to .92 at 5.5 m s−1, and the accompanying resistance factor was as low as 2.7. Among the proposed arrangements, the double‐row single‐column array arrangement was characterized by higher demisting efficiency and lower pressure drop. Overall, compared to other optimization methods, this proposed optimization approach by means of transverse vortices yielded a higher demisting efficiency and less pressure drop.
Improved performance of polyvinylidene fluoride membrane blended with modified multi‐walled carbon nanotubes by electret treatment
Authors: Shi Yuting , Wang Huashan , Hou Xiurong , Chen Anli , Yue Zhouyao 
Published: August 2023

AbstractIn this paper, electret treatment was used to enhance the electrostatic repulsion between the membrane and bovine serum albumin, so as to improve the anti‐fouling ability and recycling rate of the membrane. The polarization charge is provided by the dipole orientation of polyvinylidene fluoride (PVDF) materials, and the space charge is composed of the interfacial charge between the filler and the matrix and the bulk charge of the hollow structure of the multi‐walled carbon nanotubes. The results showed that after electret treatment, the surface potential of the membrane increased, the PVDF crystal type changed from α to β, and the crystallinity increased. Grafting of N‐vinylpyrrolidone onto multi‐walled carbon nanotubes (MWCNTs‐g‐PVP), which contain a large number of hydrophilic groups after modification, reduces the contact angle of the composite film from 86.9° to 62.7°. The pure water flux and flux recovery rate of MWCNTs‐g‐PVP/PVDF composite membranes after electret treatment was increased from 189.31 L·m−2·h−1 and 90% to 233.55 L·m−2·h−1 and 94.7%, respectively, and the rejection rate increased about 30%. Through the circulation experiment, it can be seen that the anti‐fouling performance and recycling rate of the membrane is improved, which is caused by electrostatic repulsion.
Micro is beautiful. Adoption of eco‐innovations in micro‐firms
Authors: Pronti Andrea , Zecca Emy , Antonioli Davide 
Published: August 2023

AbstractIn Europe, micro‐firms contribute significantly to both the economy and the environmental impact on ecosystems. Helping them become greener and stimulating innovation toward new sustainable and circular solutions could substantially contribute to the European goal of achieving carbon neutrality and environmental sustainability, as promoted by the European Green Deal and Next Generation EU programs. Nevertheless, eco‐innovation (EI) by micro‐firms is studied little in the literature. In this paper, we analyze the main determinants of conventional and EI adoption by micro‐firms. We used an ad‐hoc survey developed for enterprises in Emilia‐Romagna (Italy), an important region in terms of innovation where micro‐firms play a significant role in the economy. The paper analyzes whether human capital, training, R&D activities, collaboration activities to improve learning, and the environmental culture within the firm act as main determinants of innovation adoption, in addition to other standard drivers and barriers to innovation adoption studied in the extant literature. Moreover, we compare innovation adoption strategies between micro‐firms and SMEs. While our results highlight differences in the determinants of EI and conventional innovation adoption, there are important heterogeneities when it comes to innovation adoption strategies.