bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of significance of bone marrow microvessel density in myeloproliferative neoplasms in correlation with CD34 blasts, mast cell count and fibrosis
Authors: Thomas Kesiya , Rao Ranjitha , G V Chaithra , Rai Sharada , Rao A R Sneha , Basavaraju Vatsala Kudurugundi 
Published: May 2023

Background: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell diseases characterised by myeloid cell growth from one or more lineages. Angiogenesis, in contrast to other subtypes, plays a substantial role in the pathophysiology of primary myelofibrosis (PMF). Research expressing the correlation of microvessel density (MVD), blasts, fibrosis and mast cell count in MPN cases are rarely conducted. We aimed to study the significance of MVD in correlation with CD34 blasts, mast cells and fibrosis in bone marrow biopsies of MPN patients. Methods: The current research was a cross sectional study conducted on 66 cases diagnosed as MPN during a six-year period. This comprised of 32 chronic myeloid leukemia (CML), 31 PMF and three essential thrombocythemia (ET) cases. Routine staining along with reticulin stain to look for fibrosis and immunohistochemistry (IHC) using CD34 and mast cell tryptase (MCT) were performed. Results: We found increased MVD in PMF, when compared to CML and ET (p = 0.042). Further, mean MVD was observed to be increased with high blast counts (p = 0.036). On follow up, raised mean MVD was seen in those cases with relapse/deceased as compared to disease-free patients, which was highly significant (p = 0.000). Conclusions: Increased MVD score was mostly associated with PMF subtype among all the MPNs. Further, higher MVD was observed to be associated with increased blast count and poor prognosis. With angiogenesis playing a critical role in disease outcome, we now have drugs to regulate angiogenesis that are supported by contemporary research. However, further studies with larger cohorts to establish the theranostic role of MVD in MPNs is recommended.
ROOTS - Circular policies for changing the biowaste system
Authors: Suárez Miguel Ángel , Gambuzzi Elisa , Soriano Disla José M. , Castejón Gemma , Poggiaroni Giulio , Ling James 
Published: May 2023

The circular economy has a huge potential to make our societies more sustainable and decarbonised, with a reduced impact on the planet’s resources. The deployment of innovative solutions in the field of urban biowaste valorisation and reuse is still hindered by numerous bottlenecks, such as technological readiness, funding and financing tools availability, quality and quantity of biowaste and regulatory barriers. The European Green Deal and associated legislative initiatives provide the opportunity to overcome the last ones. To promote innovative solutions for the European circular bioeconomy and help to overcome the barriers for the deployment of a circular bioeconomy, five Horizon 2020 projects working on biowaste valorisation have teamed up. This joint initiative is named ROOTS - circulaR pOlicies for changing the biOwasTe System. The projects HOOP, VALUEWASTE, SCALIBUR, WaysTUP! and CITYLOOPS are piloting new solutions to transform urban biowaste (food waste and green waste) and wastewater into valuable products like feed, fertilisers, bioplastics, biopesticides, proteins and bioethanol. They use different processes and technologies, but they all rely on high levels of recycling/upcycling and propose valorisation solutions relevant to the uptake of a truly circular bioeconomy. As a result of the work performed and experience acquired, a number of bottlenecks have been identified, on the following topics: biowaste prevention, recycling targets and treatment plants, waste and by-products, biopesticides, insects for animal feed, single cell protein, citizen behaviour, investment needs. For each identified bottleneck, this open letter proposes specifically 1) policy recommendations for each level of governance, and 2) information about solutions, good practices and concrete experiences from the participating projects.
Treatment of depression with a combination of mirtazapine and venlafaxine - a literature review
Authors: Szwedkowicz Agata , Miszuda Sławomir , Trojan Sara , Fussek-Styga Urszula , Błaszczyk Agnieszka , Kwieciński Jakub , Basiaga Bartosz , Bednarz Krzysztof , Leśniak Marek , Heluszka Jakub 
Published: May 2023

Clinical depression is a psychiatric disorder characterized by symptoms such as loss of interest and pleasure from typically enjoyable activities (anhedonia), pervasive low mood, and diminished energy leading to excessive fatigue and lower activity which have been present in a patient for at least two weeks. Available therapies consist primarily of pharmacological intervention. Indeed, some groups of medications such as SSRIs, SNRIs, TCA’s and tetracyclic antidepressants have been used to treat depression for decades, frequently in combinations. An example of such a combination is “California Rocket Fuel” composed of venlafaxine and mirtazapine

Objective:

To review the current literature on the efficacy of the combination of venlafaxine and mirtazapine in treating clinical depression both in drug-resistant depression and as a first-line option. To explore the risks and benefits of this choice of therapy and discuss its potential mechanism of action.

Methods:

Literature review of Pubmed, Google Scholar, Science Direct, and available medical textbooks.

Conclusions:
Treatment with venlafaxine and mirtazapine is safe, especially for drug-resistant depression. It is worth considering adding venlafaxine to already ongoing pharmacotherapy with mirtazapine when the patient experiences sleepiness and the symptoms of depression have not been sufficiently reduced. Augmenting venlafaxine treatment with mirtazapine also seems necessary when the patient complains of insomnia. One may consider implementing such therapy as a first-line treatment in patients who suffer from depression for a long time and experience insomnia in its course.
Pricing for the Stars: Dynamic Pricing in the Presence of Rating Systems
Authors: Carnehl Christoph , Stenzel André , Schmidt Peter 
Published: May 2023

Maintaining good ratings increases the profits of sellers on online platforms. We analyze the role of strategic pricing for ratings management in a setting where a monopolist sells a good of unknown quality. Higher prices reduce the value for money, which on average worsens reviews. However, higher prices also induce only those consumers with a strong taste for the product to purchase, which on average improves reviews. Our model flexibly parametrizes the two effects. This parametrization can rationalize the observed heterogeneity in the relationship between reviews and prices. Based on an analytic characterization of the optimal dynamic pricing strategy, we study a platform’s choice of the sensitivity of its rating system to incoming reviews. The optimal sensitivity depends on the effect of prices on reviews and on how the platform weighs consumers and sellers in its objective. Although sellers always benefit from more sensitivity, consumers may suffer from higher prices and from slower learning from reviews due to endogenously emerging price and rating cycles. This paper was accepted by Kartik Hosanagar, information systems. Funding: This work was supported by the Deutsche Forschungsgemeinschaft [CRC TR 224, Project C3]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4771 .
A One-Factor Model of Corporate Bond Premia
Authors: Elkamhi Redouane , Jo Chanik , Nozawa Yoshio 
Published: May 2023

A one-factor model based on long-run consumption growth explains the risk premiums on corporate bond portfolios sorted on credit rating, credit spreads, downside risk, idiosyncratic volatility, long-term reversals, maturity, and sensitivity to the financial intermediary capital factor. The estimated risk-aversion coefficient is lower when we use the consumption growth of wealthy households over a longer horizon as a risk factor, and a model with a 20-quarter horizon yields a risk-aversion coefficient of 15, a value similar to the one estimated from equity portfolios. This paper was accepted by Bruno Biais, finance. Funding: Y. Nozawa acknowledges funding from the Center for Investing at the Hong Kong University and Science and Technology. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4784 .
Managing Operations of a Hog Farm Facing Volatile Markets: Inventory and Selling Strategies
Authors: Kouvelis Panos , Liu Ye , Qiu Yunzhe , Turcic Danko 
Published: May 2023

Problem definition: We study a dynamic finishing-stage planning problem of a pork producer who at the beginning of each week gets to see how many market-ready hogs she has available for sale and the current market prices. Then, she must decide which hogs to sell to a meatpacker and on the open market and which hogs to hold until the following week. The farmer is contracted to deliver a fixed quantity of hogs to the meatpacker each week priced according to a contractually predetermined market index. If the farmer underdelivers to the meatpacker, she pays a contractually predetermined unit penalty also linked to a market index. Biosecurity protocols prevent the farmer from buying hogs on the open market and selling them to the meatpacker. The farmer can, however, use the open market to sell hogs for prevailing market prices. Methodology/Results: We treat the problem as a dynamic, multiitem, nonstationary inventory problem with multiple sources of uncertainty. The optimal policy is a threshold policy with multiple price-dependent thresholds. The computational complexity required to evaluate the thresholds is the biggest impediment to using the optimal policy as a decision-support tool. So, we utilize an approximate dynamic programming approach that exploits the optimal policy structure and produces a sharp heuristic that is easy to implement. Managerial implications: Numerical experiments calibrated to a pork producer’s data reveal that the optimal policy with the heuristically estimated thresholds substantially improves the existing practice (around 25% on average). The success of the proposed model is attributed to recognizing the value of holding underweight hogs and effectively hedging supply uncertainty and future prices—an insight missed in the planning actions of the current practice.Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1216 .
Visualidades da Cultura Surda: grupo Deaf View/Image Art
Authors: Carneiro Isabel Almeida , Waltenberg Layla 
Published: May 2023

Buscamos neste ensaio apontar contribuições da produção artística elaborada com a experiência da surdez, à luz do movimento De’VIA (Deaf View/Image Art). Devido à marginalização de trabalhos e artistas que não integram o sistema da arte contemporânea, elencamos artistas e coletivos nacionais e internacionais que, muitas vezes utilizando as línguas de sinais, expressam em seus trabalhos visuais a luta por reconhecimento e visibilidade da cultura surda.
Fifty years of glass ionomers (GICs). Are the latest GICs suitable for restoring back teeth?
Authors: Burke FJ Trevor , Mackenzie Louis , Sands Peter 
Published: May 2023

Glass ionomer cements (GICs) have been available for use by clinicians for almost 50 years. Their beneficial properties, such as adhesion to tooth substance, have long been recognized, but early materials suffered from brittleness, lack of translucency, poor wear resistance and solubility in oral fluids. Hence, over the years, new variants have been developed with a view to overcoming these difficulties. If the latest materials were found to be clinically successful in loadbearing situations in posterior teeth, they could hold advantages because of their easier placement than resin composite materials and possibly be more cost-effective. It is therefore the purpose of this article to review recent research into the performance of the laboratory and clinical performance of high viscous GICs and the so-called glass hybrid materials that have developed from the conventional GICs. CPD/Clinical Relevance: Glass ionomer materials, which, unlike resin composite restorations do not need a separate bonding agent, may hold technique advantages during restoration placement.
Dentistry: a reflective and prospective perspective. Have we gone full circle?
Authors: Chandrapal Andrew 
Published: May 2023

The face of dentistry is in constant flux. The totality of factors that occur under the umbrella of dentistry worldwide is a fast moving target and as such, can sometimes be challenging. In honour of Dental Update's golden anniversary, the purpose of this article is to reflect on current innovations and take a look at where the profession is heading in terms of development and technology that promises to add to patient care and quality of outcomes. CPD/Clinical Relevance: Knowledge of innovations in dental techniques and materials is essential for good clinical practice.
Scalable, fiber-compatible lithium-niobate-on-insulator micro-waveguides for efficient nonlinear photonics
Authors: Zhang Yuting , Li Hao , Ding Tingting , Huang Yiwen , Liang Longyue , Sun Xuerui , Tang Yongzhi , Wang Jiayu , Liu Shijie , Zheng Yuanlin , Chen Xianfeng 
Published: May 2023

Efficient wave mixers based on lithium-niobate-on-insulator (LNOI) hold great potential for next-generation photonic integrated circuits in both classical and quantum optics. However, achieving high-performance nonlinear photonic devices readily suitable for scalable, fiber-compatible applications remains challenging. Here, we report on the fabrication of LNOI micrometer waveguides, i.e., micro-waveguides, with a combination of ultraviolet lithography and deep dry etching technology for efficient nonlinear photonics applications. We fabricate periodically poled LNOI micro-waveguides with a cross section of ∼3×4µm2 and demonstrate a fiber–chip–fiber second-harmonic generation conversion efficiency of 1320%/W with an insertion loss of 3.8 dB at the telecommunication band. We also demonstrate high-quality photon pair generation via spontaneous parametric downconversion with a flux of 178 MHz/mW at sub-mW pump power and coincidence-to-accidental ratio >8000 at microwatt pump power. The overall performance in both applications is on par with that of state-of-the-art counterparts using thin-film lithium niobate nano-waveguides. The technique would make micrometer-thick LNOI an attractive platform for ready applications in nonlinear and quantum optics.
The Nature of Social Humanistic Thought in Ancient China
Authors: Abdul Hay Omar 
Published: May 2023

Abstract
Geographical reality and diverse historical conditions left a significant impact on Chinese agricultural life since its beginning and throughout its later stages of growth. In light of it, intellectual structures were formed in ancient China over many centuries. Led by Confucianism and Daoism, various schools of ancient Chinese thoughts succeeded in forming intellectual foundations in social, humanistic and political dimensions. These thoughts came to express the achievements of Chinese humanistic development, which adheres to the customs, traditions, and virtuous family and community moral principles. Their effects are still evident today in modern Chinese humanistic thought.
The New Evolution of China’s Diplomacy with Arab States Under the Background of the Sino- U.S. Competition: Trends and Prospects
Authors: Chen Jie 
Published: May 2023

Abstract
The interaction between China and Arab countries has a long history. After entering the 21stcentury, China-Arab relations have ushered in many important stages. In July 2018, the two sides agreed to establish a strategic partnership, which has become a new historical beginning for China-Arab friendly cooperation. At the same time, Sino-US relations plummeted. The United States changed its strategic positioning towards China, strengthened its containment of China, and opened the era of Sino-U.S. strategic competition. Therefore, China-Arab relations will be in an important field of strategic competition between China and the United States, which will become an important variable affecting the development of China-Arab relations. Starting from the internal and external factors affecting China-Arab relations, this paper intends to further analyze the changes in China’s diplomatic style of becoming more active in participating in Arab affairs and diversifying the fields and modes of exchange between the two sides under the current background of great power competition, then clarify the unity of stage and long-term, response and initiative, context and totality, and theory and practice embodied in such changes. At present, China must not only recognize the strategic significance of Arab countries, but also correctly understand the strategic contraction of the United States in the Middle East, and further consolidate China-Arab relations, expand the increment of cooperation, and pay attention to each other’s core interests by strengthening the frequency of diplomacy between heads of state, strengthening the use of multilateral mechanisms, strengthening the docking of development strategies, strengthening the supply of public goods, and strengthening exchanges and mutual learning among civilizations.
Assessing patient experience of the tenets of osteopathic medicine
Authors: Davis Glenn E. , Hartwig Walter Carl , Riemer Richard B. , Char Chandra , McTighe Adam , Kremelberg David 
Published: May 2023

Abstract

Context
Previous studies document that both osteopathic physicians and third-party observers identify an approach to the patient that is consistent with the philosophy and tenets of osteopathic medicine, often without investigating whether patients identify or are satisfied with it. Osteopathic physicians and the medical education community understand the distinctiveness of an osteopathic approach to the patient. Understanding the outcomes of an osteopathic approach to patient care includes confirming whether patients experience the tenets of osteopathic medicine in physician visits and, if so, how it relates to their experience of physician empathy and satisfaction with the visit.

Objectives
The objectives of this study were to assess patient experience of the tenets of osteopathic medicine, physician empathy, and satisfaction with the visit and to compare the results for patients who saw DOs with those who saw MD physicians.

Methods
More than 2000 patients at four outpatient clinic facilities were surveyed after a clinical visit on 22 prompts regarding their experiences of physician behaviors, physician empathy, and their own satisfaction with the encounter. Adult patients who were treated by an osteopathic or allopathic physician for a nonemergency encounter and who were not pregnant were included in the analysis. Survey results for 1,330 patient–physician encounters were analyzed utilizing linear regression models comparing constructs representing patient experiences of the tenets of osteopathic medicine (Tenets), physician empathy (Physician Empathy), satisfaction (Satisfaction) with the encounter, as well as additional demographic and encounter variables.

Results
Approximately 23.8 % of patients approached during the study period completed a survey (n=2,793), and among those, 54.7 % of patients who consented to the study and who saw a physician provider (n=1,330/2,431) were included. Significant (p≤0.01), positive associations among patient experiences of Satisfaction with the visit and Physician Empathy were observed among those who saw both DO and MD physicians. Patients experienced the Tenets during encounters with both DO and MD physicians, but linear regression showed that their experience of the Tenets was significantly (p≤0.01) and positively explained by their experience of Physician Empathy (β=0.332, p=0.00, se=0.052) and Satisfaction with the visit (β=0.209, p=0.01, se=0.081) only when the physician was a DO.

Conclusions
Patients identified physician behaviors consistent with the Tenets and positively associated their experiences of Physician Empathy and Satisfaction with the visit regardless of physician training background. Patient experience of the Tenets significantly explained their experiences of Physician Empathy and Satisfaction after visits with a DO but not after visits with an MD.
Abundance and activity patterns of the endangered margay (Leopardus wiedii) in temperate forest remnants from the avocado landscape in Mexico
Authors: Monterrubio-Rico Tiberio C. , Gallardo-Téllez Eduardo G. , López-Ortiz Eduardo I. , Rodríguez-Correa Hernando , Charre-Medellín Juan F. 
Published: May 2023

Abstract
A survey was done to estimate margay abundance and activity in the context of high forest loss rates from avocado plantations for the temperate forest region of Michoacán state. Camera trap surveys were conducted from November 2015 to April 2020, recording 21 Margay detections of seven individuals. The capture rate ranged from 0.09 to 0.83 records/100 trap nights. The mean temporal density was 0.12 ind./km2, with an activity peak between 04:00 and 05:00 h. The Margay could serve as indicator species for restoration and forest conservation initiatives.
Arte, memória e saúde em territórios expandidos: tecendo redes de afetos ou arte pode não curar, mas sua ausência adoece
Authors: Amaral Lilian 
Published: May 2023

A presente discussão propõe estabelecer um diálogo entre os campos da arte urbana contemporânea e saúde pública, em uma perspectiva histórica, a partir da presença dos CECCOS – Centros de Convivência e Cooperativa da cidade de São Paulo e o projeto de arte colaborativa TOQUE – instalação em processo | autoria compartilhada, considerando a realização da exposição processual realizada na Universidade de São Paulo, na galeria e espaço expositivo da Biblioteca Brasiliana, Fundação Guita e José Mindlin, em 2019. Olhares Transversos, espaço de memória, copesquisa e cocriação estabeleceram interlocuções entre os campos da criação poética como espaços de vida e potência existencial, ao mesmo tempo que reescreve a história da cultura urbana em suas interfaces interseccionais, interculturais e transdisciplinares.Palavras-chave: Arte urbana contemporânea, Saúde pública, CECCO - Centro de Convivência e Cooperativa, Toque, Arte colaborativa. Art, Memory and Health in Expanded Territories: Weaving Affect Networks or Art May Not Cure, But its Absence SickensAbstract: The present discussion proposes to establish a dialogue between the fields of contemporary urban art and public health, in a historical perspective, beginning with the existence of CECCOS – Center of Coexistence and Cooperative in the city of São Paulo, SP, Brazil and the collaborative art project TOQUE – installation in process | shared authorship, considering the realization of the processual exhibition held at the University of São Paulo, in the gallery and exhibition space at the Biblioteca Brasiliana, Fundação Guita and José Mindlin, in 2019. Transversals, memory space, coresearch and cocreation establish interlocutions between the areas of poetic creation as spaces of life and existential potency, while rewriting the history of urban culture in its intersectional, intercultural and transdisciplinary interfaces.Keywords: Urban contemporary art; Public health; CECCO – Community and Cooperative Center; Touch; Collaborative art.