bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination prediction and error analysis of conventional gas production in Sichuan Basin
Authors: Li Haitao , Yu Guo , Chen Yanru , Fang Yizhu , Chen Yu , Zhang Dongming 
Published: September 2023

The accurate prediction of the trend of natural gas production changes plays an important role in the formulation of development planning plans. The conventional gas exploration and development in Sichuan Basin has a long history. Based on the development of conventional natural gas production, the article uses the Hubbert model, Gauss model, and GM (1, N) model to predict conventional natural gas production, and then the Shapley value method is used to allocate the weight values of the three models, and a combination model for conventional gas production prediction is established. Finally, residual analysis and precision test are carried out on the prediction results. The results show that: 1) The combination model established using the Shapley value method can effectively combine the advantages of various models and improve the accuracy of prediction. And the standardized residual of the combined model is the lowest, the prediction is closest to the actual value, and the accuracy test is the best, indicating that the combined model has the highest accuracy. 2) After using a combination model for prediction, conventional gas production will peak in 2046, with a peak production of 412 × 108 m3, with a stable production period of (2038–2054) years, a stable production period of 17 years, and a stable production period of 389 × 108 m3, the predicted results of the combined model have a longer stable production period, and the trend of production changes is more stable. The use of combination model provides a reference for the field of natural gas prediction, while improving the accuracy of prediction results and providing better guidance for production planning.
Effect of emotional exhaustion on satisfaction with studies and academic procrastination among Peruvian university students
Authors: Carranza Esteban Renzo Felipe , Mamani-Benito Oscar , Castillo-Blanco Ronald , Caycho-Rodríguez Tomás , Villafuerte de la Cruz Avelino Sebastián , Dávila Villavicencio Roussel 
Published: September 2023

ObjectiveTo examine the effect of emotional exhaustion on satisfaction with studies and academic procrastination among Peruvian university students.MethodsAn explanatory study was conducted with 1,011 Peruvian university students (60.2% women and 39.8% men). The Brief Satisfaction with Studies Scale (EBSE), Emotional Exhaustion Scale (ECE), and the Academic Procrastination Scale (EPA) were used to measure the variables.ResultsThe results revealed that the explanatory model had an acceptable fit, χ2(1) = 7.7, p = 0.006, CFI = 0.982, RMSEA = 0.081, SRMR = 0.021. These findings provide evidence that emotional exhaustion negatively affects satisfaction with studies (β = −0.30, p &lt; 0.001) and positively influences academic procrastination (β = 0.15, p &lt; 0.001).ConclusionEmotional exhaustion is decisive in satisfaction with studies and academic procrastination.
Interannual variation in evapotranspiration in an urban forest reserve with respect to drought
Authors: Yang Ruizhi , Liu Peng , Tian Yun , Ma Jingyong , Bai Yujie , Li Cheng , Huang Songyu , Mu Yanmei , Hayat Muhammad , Iqbal Sundas , Yu Haiqun , Zhang Feng , Ma Hong 
Published: September 2023

IntroductionA warming global climate is expected to perturb the hydrological cycle, resulting in deviations in both frequency and duration of drought and thus being hypothesized to lead to interannual variation in evapotranspiration (ET). Interannual variation in ET in urban forest ecosystems in response to drought remains poorly understood.MethodsHere, ET in an urban forest reserve in the megalopolis of Beijing was investigated using eddy-covariance measurements collected over six consecutive years (2012–2017).ResultsThe mean annual cumulative ET was 462 ± 83mm (±first standard deviation), with a coefficient of variation of 18%. Interannual variation in both annual and monthly ET was shown to be largely controlled by canopy conductance (gs), affected by environmental factors. The main factors affecting interannual variation in monthly ET varied seasonally, namely, soil volumetric water content (VWC) and normalized difference vegetation index (NDVI) in spring, precipitation and soil temperature in summer, and VWC and net radiation (Rn) in autumn. Interannual variation in annual ET was driven largely by spring and mid-summer droughts induced by insufficient precipitation during the non-growing and mid-growing seasons, respectively. Spring drought reduced annual ET by restricting leafing out, shortening growing season length (GSL), and reducing the normalized difference vegetation index (NDVI). The summer drought reduced annual ET by reducing stomatal conductance.Discussion and conclusionResults from this study point to the importance of precipitation timing and volume and the soil moisture carry-over effect in controlling interannual variation in ecosystem ET. Irrigation during the early spring and mid-summer is viewed as a practical management measure for sustaining growth and better ecosystem services in urban forests in Northern China.
Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation in vitro and dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita
Authors: Yang Kai , Yin Junping , Yue Xiaoyang , Bieber Katja , Riemekasten Gabriela , Ludwig Ralf J. , Petersen Frank , Yu Xinhua 
Published: September 2023

IntroductionNatural products have been shown to an important source of therapeutics for human disease. In this study, we aimed to identify natural compounds as potential therapeutics for epidermolysis bullosa acquisita (EBA), an autoimmune disease caused by autoantibodies to type VII collagen (COL7).MethodsUtilizing an in vitro experimental system, we screened a natural product library composed of 800 pure compounds for their inhibitory effect on COL7-anti-COL7 IgG immune complex (IC)-mediated neutrophil activation and on neutrophil-mediated tissue damage.ResultsThree natural compounds, namely luteolin peracetate, gossypol, and gossypolone were capable in inhibiting the IC-induced neutrophil adhesion and oxygen burst in vitro. Furthermore, luteolin peracetate and gossypolone were able to inhibit the anti-COL7 IgG induced dermal-epidermal separation in an ex vivo model for EBA.DiscussionIn summary, this study demonstrates that luteolin peracetate and gossypolone are potential therapeutics for experimental EBA, which deserves further investigation.
“Spotting” Mycobacterium bovis infection in leopards (Panthera pardus) – novel application of diagnostic tools
Authors: Gumbo Rachiel , Goosen Wynand J. , Buss Peter E. , de Klerk-Lorist Lin-Mari , Lyashchenko Konstantin , Warren Robin M. , van Helden Paul D. , Miller Michele A. , Kerr Tanya J. 
Published: September 2023

BackgroundMycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (TB) which poses a threat to many of South Africa’s most iconic wildlife species, including leopards (Panthera pardus). Due to limited tests for wildlife, the development of accurate ante-mortem tests for TB diagnosis in African big cat populations is urgently required. The aim of this study was to evaluate currently available immunological assays for their ability to detect M. bovis infection in leopards.MethodsLeopard whole blood (n=19) was stimulated using the QuantiFERON Gold Plus In-Tube System (QFT) to evaluate cytokine gene expression and protein production, along with serological assays. The GeneXpert® MTB/RIF Ultra (GXU®) qPCR assay, mycobacterial culture, and speciation by genomic regions of difference PCR, was used to confirm M. bovis infection in leopards.ResultsMycobacterium bovis infection was confirmed in six leopards and individuals that were tuberculin skin test (TST) negative were used for comparison. The GXU® assay was positive using all available tissue homogenates (n=5) from M. bovis culture positive animals. Mycobacterium bovis culture-confirmed leopards had greater antigen-specific responses, in the QFT interferon gamma release assay, CXCL9 and CXCL10 gene expression assays, compared to TST-negative individuals. One M. bovis culture-confirmed leopard had detectable antibodies using the DPP® Vet TB assay.ConclusionPreliminary results demonstrated that immunoassays and TST may be potential tools to identify M. bovis-infected leopards. The GXU® assay provided rapid direct detection of infected leopards. Further studies should aim to improve TB diagnosis in wild felids, which will facilitate disease surveillance and screening.
Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection
Authors: Hartmann Ann-Kathrin , Bartneck Joschka , Pielenhofer Jonas , Meiser Sophie Luise , Arnold-Schild Danielle , Klein Matthias , Stassen Michael , Schild Hansjörg , Muth Sabine , Probst Hans Christian , Langguth Peter , Grabbe Stephan , Radsak Markus P. 
Published: September 2023

IntroductionTranscutaneous immunization (TCI) is a non-invasive vaccination method promoting strong cellular immune responses, crucial for the immunological rejection of cancer. Previously, we reported on the combined application of the TLR7 agonist imiquimod (IMQ) together with the anti-psoriatic drug dithranol as novel TCI platform DIVA (dithranol/IMQ based vaccination). In extension of this work, we further optimized DIVA in terms of drug dose, application pattern and established a new IMQ formulation.MethodsC57BL/6 mice were treated on the ear skin with dithranol and IMQ-containing ointments together with ovalbumin-derived peptides. T cell responses were determined by flow cytometry and IFN-ɤ ELISpot assay, local skin inflammation was characterized by ear swelling.ResultsApplying the adjuvants on separate skin sites, a reduced number of specific CD8+ T cells with effector function was detectable, indicating that the local concurrence of adjuvants and peptide antigens is required for optimal vaccination. Likewise, changing the order of dithranol and IMQ resulted in an increased skin inflammatory reaction, but lower frequencies of antigen-specific CD8+ T cells indicating that dithranol is essential for superior T cell priming upon DIVA. Dispersing nanocrystalline IMQ in a spreadable formulation (IMI-Sol+) facilitated storage and application rendering comparable immune responses. DIVA applied one or two weeks after the first immunization resulted in a massive increase in antigen-specific T cells and up to a ten-fold increased memory response. Finally, in a prophylactic tumor setting, double but no single DIVA treatment enabled complete control of tumor growth, resulting in full tumor protection.DiscussionTaken together, the described optimized transcutaneous vaccination method leads to the generation of a strong cellular immune response enabling the effective control of tumor growth and has the potential for clinical development as a novel non-invasive vaccination method for peptide-based cancer vaccines in humans.
Development and validation of a predicted nomogram for mortality of COVID-19: a multicenter retrospective cohort study of 4,711 cases in multiethnic
Authors: Shi Yuchen , Zheng Ze , Wang Ping , Wu Yongxin , Liu Yanci , Liu Jinghua 
Published: September 2023

BackgroundCoronavirus disease 2019 (COVID-19) is an infectious disease spreading rapidly worldwide. As it quickly spreads and can cause severe disease, early detection and treatment may reduce mortality. Therefore, the study aims to construct a risk model and a nomogram for predicting the mortality of COVID-19.MethodsThe original data of this study were from the article “Neurologic Syndromes Predict Higher In-Hospital Mortality in COVID-19.” The database contained 4,711 multiethnic patients. In this secondary analysis, a statistical difference test was conducted for clinical demographics, clinical characteristics, and laboratory indexes. The least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression analysis were applied to determine the independent predictors for the mortality of COVID-19. A nomogram was conducted and validated according to the independent predictors. The area under the curve (AUC), the calibration curve, and the decision curve analysis (DCA) were carried out to evaluate the nomogram.ResultsThe mortality of COVID-19 is 24.4%. LASSO and multivariate logistic regression analysis suggested that risk factors for age, PCT, glucose, D-dimer, CRP, troponin, BUN, LOS, MAP, AST, temperature, O2Sats, platelets, Asian, and stroke were independent predictors of CTO. Using these independent predictors, a nomogram was constructed with good discrimination (0.860 in the C index) and internal validation (0.8479 in the C index), respectively. The calibration curves and the DCA showed a high degree of reliability and precision for this clinical prediction model.ConclusionAn early warning model based on accessible variates from routine clinical tests to predict the mortality of COVID-19 were conducted. This nomogram can be conveniently used to facilitate identifying patients who might develop severe disease at an early stage of COVID-19. Further studies are warranted to validate the prognostic ability of the nomogram.
Gastric xanthelasma is a warning sign for Helicobacter pylori infection, atrophic gastritis, and intestinal metaplasia
Authors: Feng Lina , Zhang Mingyu , Guan Jialun , Zhang Yu , Huang Yujie , Dong Ruonan , Zhao Kai , Xia Suhong , Xiao Fang , Liao Jiazhi 
Published: September 2023

BackgroundContradictory evidence suggested gastric xanthelasma (GX) was associated with some upper gastrointestinal (GI) diseases. Additionally, no research has been performed on the relationship between esophageal/duodenal xanthelasma and upper GI diseases.MethodsIndividuals who underwent esophagogastroduodenoscopy at Tongji Hospital, Tongji Medical College, participated in this retrospective study. This study evaluated whether the risk of GX or esophageal/duodenal xanthelasma was influenced by the following gastroesophageal diseases: superficial gastritis, gastric polyp, bile reflux, peptic ulcer, reflux esophagitis, Barrett’s esophagus, esophageal cancer, atrophic gastritis (AG), intestinal metaplasia (IM), dysplasia, gastric cancer, and Helicobacter pylori (H. pylori) infection. Furthermore, subgroup analysis was conducted to establish the relationship between the number of GX and upper GI diseases.ResultsOf the 69,071 subjects reviewed, 1,220 (1.77%) had GX, and 54 (0.08%) had esophageal/duodenal xanthelasma. There was no difference in the prevalence of upper GI diseases between patients with and without esophageal/duodenal xanthelasma. Nevertheless, compared with non-xanthelasma patients, GX patients had a greater proportion of AG, IM, dysplasia, gastric cancer, and H. pylori infection and a lower incidence of superficial gastritis (p &lt; 0.05). The multivariate logistic regression analysis indicated AG (OR = 1.83, 95%CI: 1.56–2.16), IM (OR = 2.42, 95%CI: 2.41–2.85), and H. pylori infection (OR = 1.32, 95%CI: 1.17–1.50) were independent risk factors for GX. In addition, patients with multiple GXs had a higher rate of AG and IM than those with single GX.ConclusionEsophageal/duodenal xanthelasma may not be associated with upper GI diseases, and further research is needed to support this hypothesis. Notably, GX, especially multiple GXs, may be a more easily detected warning sign of AG, IM, or H. pylori infection.
Development and validation of a deep learning-based automatic segmentation model for assessing intracranial volume: comparison with NeuroQuant, FreeSurfer, and SynthSeg
Authors: Suh Pae Sun , Jung Wooseok , Suh Chong Hyun , Kim Jinyoung , Oh Jio , Heo Hwon , Shim Woo Hyun , Lim Jae-Sung , Lee Jae-Hong , Kim Ho Sung , Kim Sang Joon 
Published: September 2023

Background and purposeTo develop and validate a deep learning-based automatic segmentation model for assessing intracranial volume (ICV) and to compare the accuracy determined by NeuroQuant (NQ), FreeSurfer (FS), and SynthSeg.Materials and methodsThis retrospective study included 60 subjects [30 Alzheimer’s disease (AD), 21 mild cognitive impairment (MCI), 9 cognitively normal (CN)] from a single tertiary hospital for the training and validation group (50:10). The test group included 40 subjects (20 AD, 10 MCI, 10 CN) from the ADNI dataset. We propose a robust ICV segmentation model based on the foundational 2D UNet architecture trained with four types of input images (both single and multimodality using scaled or unscaled T1-weighted and T2-FLAIR MR images). To compare with our model, NQ, FS, and SynthSeg were also utilized in the test group. We evaluated the model performance by measuring the Dice similarity coefficient (DSC) and average volume difference.ResultsThe single-modality model trained with scaled T1-weighted images showed excellent performance with a DSC of 0.989 ± 0.002 and an average volume difference of 0.46% ± 0.38%. Our multimodality model trained with both unscaled T1-weighted and T2-FLAIR images showed similar performance with a DSC of 0.988 ± 0.002 and an average volume difference of 0.47% ± 0.35%. The overall average volume difference with our model showed relatively higher accuracy than NQ (2.15% ± 1.72%), FS (3.69% ± 2.93%), and SynthSeg (1.88% ± 1.18%). Furthermore, our model outperformed the three others in each subgroup of patients with AD, MCI, and CN subjects.ConclusionOur deep learning-based automatic ICV segmentation model showed excellent performance for the automatic evaluation of ICV.
Prevalence, incidence, and re-occurrence risk of musculoskeletal pain in older adults in the United Kingdom: a population-based study
Authors: Radojčić Maja R. , Perera Romain S. , Hart Deborah J. , Spector Tim D. , Arden Nigel K. 
Published: September 2023

BackgroundThroughout the literature, pain burden has been assessed by asking different questions, often cross-sectionally, different populations of interest. We know little about pain re-occurrence and how to translate knowledge between pain questions within the population of interest. We aimed to estimate the burden of musculoskeletal pain by estimating prevalence, incidence rates, and re-occurrence risk of back, hand, hip, knee, and foot pain using different questions from UK population-based samples and predict the number of affected individuals in the UK in 2030.MethodsWe used two UK population-representative studies, with two eight-year-apart follow-ups and two pain questions assessing recent pain episodes and often troubled pain when walking. We estimated prevalence, 8-year incidence rates, and 8-year pain re-occurrence risk for women and men aged 50 years and older and the relation between the two pain questions.ResultsAmong UK individuals older than 50 years, the prevalence of musculoskeletal pain episode was 20%–50%, and the incidence was 20–40/1,000 person-years, while the prevalence of pain when walking was 10%–25%, and the incidence was 6–12/1,000 person-years. The most prevalent musculoskeletal pain types were back and knee pain; of five women experiencing back or knee pain episodes, three are expected to be often troubled by pain. Hip and foot pain had similar estimates in both questions. Hand pain peaked in women aged 50–65 years. Women had higher prevalence and incidence rates, but men had higher 8-year re-occurrence risk of all types of musculoskeletal pain. Reporting a pain episode was associated with two times higher risk, but often troubled by pain when walking was associated with four to seven times times higher risk of the same pain in 8 years. Women and men with a body mass index (BMI) of ≥27 kg/m2 were twice as likely to experience musculoskeletal pain than those with BMI&lt;27 kg/m2. In 2030, we expect 2–7 million people older than 50 years in the United Kingdom to seek site-specific musculoskeletal pain-focused healthcare.ConclusionsIn individuals older than 50 years, the experience of musculoskeletal pain at least doubles the chance of experiencing it again. Women report musculoskeletal pain more often, but men report more persistent pain. Musculoskeletal pain presents a significant burden to public health.
Case report—Every thoracic surgeon's nightmare: cardiac and lung perforation during placement of Nuss bar for pectus excavatum
Authors: Beati Federico , Frediani Simone , Pardi Valerio , Aloi Ivan , Bertocchini Arianna , Accinni Antonella , Inserra Alessandro 
Published: September 2023

IntroductionThe prevalence of life-threatening complications (LTCs) related to the minimally invasive repair of pectus excavatum (MIRPE) is unknown and underreported. The aim of this study is to contribute to the real prevalence of these rare but dramatic complications and show what went wrong in order to prevent it in the future.Case presentationA 15-year-old boy affected by pectus excavatum with severe asymmetric deformity of the chest wall was evaluated for elective corrective surgery. Preoperative computed tomography showed a Haller index of 5.7 and a correction index of 0.40. MIRPE was performed under right video-assisted thoracoscopy. Cardiac arrhythmias occurred after placement of the bar introducer. The introducer was removed, and massive bleeding was noted. Emergency Clamshell thoracotomy was performed, and cardiac surgeon was alerted immediately. A first pulmonary wound was found and controlled. Two cardiac lacerations were found: on the interventricular wall and on the right atrium. Under cardiopulmonary bypass, cardiac lacerations were sutured and other three pulmonary wounds were repaired. An urgent fasciotomy was performed for compartmental syndrome of the right lower art after femoral cannulation. Pulmonary distress occurred; the patient was admitted on ECMO (ExtraCorporeal Membrane Oxygenation) in intensive care unit. Right lower lobectomy was carried out on the fifth postoperative day due to massive pulmonary bleeding requiring temporary tracheostomy. The patient was discharged to rehabilitation after 3 months with no brain injuries, minor hearing loss, and tracheostomy.ConclusionWe want to maintain the high alertness required for this procedure. Reporting these scaring complications contributes to the real prevalence of LTCs. We suggest the use of bilateral thoracoscopy and crane elevator in severe sternal defects. We also suggest to have a cardiac surgeon available in the hospital owing to cardiac perforation.