bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis and application of financial market investment strategy based on data mining and cloud computing service system
Authors: Pu Ganlin 
Published: March 2023

Abstract
As a new information service model, cloud computing service system is the current research hotspot. It provides reliable and cheap computing resources for users in need through service access. Using virtualization technology, the cloud computing service system converts large and complex physical resources in the cloud environment into various types of virtual resource pools, and implements deployment in an integrated management and automated manner. Currently, competition in the Internet financial market is becoming increasingly fierce. Internet finance companies use various methods and channels to attract and retain users, and many users are more likely to invest in multiple platforms at the same time. In such a fiercely competitive environment, the cost of the company in order to win customers is getting higher and higher, but the growth of new users is still slow. In the long run, the company's losses in the financial market have been huge, especially when it loses high-quality users. Investment strategy analysis has important social significance for the development and improvement of China's securities market. At present, the conditions for establishing a short-selling mechanism in China are becoming more and more mature, and the corresponding conditions are also being actively used, which has further promoted the development of short-selling mechanisms in the financial market. Due to the feasibility of implementing the short-selling mechanism, this article mainly analyzes the establishment of the short-selling mechanism and the investment strategy of the Chinese securities market to improve theoretical references.
Intelligent logistics economic service development based on 5G Iot and visual tracking
Authors: Sheng Zhipeng 
Published: March 2023

Abstract
It is difficult for 4G networks to meet the needs of intelligence. The emergence of 5G communication technology provides an interconnected infrastructure for everything we have been waiting for, and establishes continuous informatization, which has an important impact on our economy and society. The Internet of Things has created new opportunities for the development of the logistics industry with a qualitative development method. 4G technology is difficult to support the development of logistics companies to increase storage capacity and popularize cloud computing. In the process of informatization development, relevant information is gradually exposed. The rational use of 5G technology is the key to the overall development of logistics and warehouse computerization. In this article, we incorporate the IMU measurement value based on the binocular hybrid tracking visual mileage to implement the tightly coupled binocular VIO algorithm based on the state of the indirect Kalman filter. The algorithm in the visual tracking process will extract the ORB feature points of each frame in the image library, and combine the IMU measurement values to predict the projection position of the landmark points and accelerate the matching. Through the construction of the Internet-based intelligent logistics system of the Internet of Things, in the supply chain optimization planning, the system design and research ideas continue to innovate, how small and medium-sized technology manufacturers represented by A company are in a leading position in the industry, has universal significance. Therefore, this article will continue to explore in depth the construction, development and research of intelligent logistics, warehouse information systems for 5G new technologies.
Phylogeography of the Siberian roe deer in Eurasia and origin of the Siberian mtDNA lineage in European roe deer populations
Authors: Plis Kamila , Niedziałkowska Magdalena , Danilkin Aleksey , Kholodova Marina , Zvychaynaya Elena , Kashinina Nadezhda , Bunevich Aleksey , Okhlopkov Innokentiy , Mamaev Nikolay , Kusza Szilvia , Shkvyria Maryna , Paule Ladislav , Veeroja Rauno , Paulauskas Algimantas , Krapal Ana-Maria , Tiainen Juha , Jędrzejewska Bogumiła 
Published: March 2023

Abstract
The Siberian roe deer (Capreolus pygargus) is distributed throughout the continental Asia. Nowadays in eastern Europe there have been detected individuals of C. capreolus with mtDNA of C. pygargus but the origin of this introgression is not clear as there have been not many data available concerning the phylogenetic pattern of the Siberian roe deer. To reveal the source of the introgression and to provide the most comprehensive picture of Siberian roe deer phylogeography we analyzed mtDNA control region fragment (610bp) of 352 roe deer samples combined with 139 sequences available in GenBank. We detected 105 haplotypes and seven mtDNA haplogroups. The proportion of different haplogroups in the regional populations varied longitudinally, with a major shift in Central Siberia. Haplogroups A, C and E were the most frequent in Europe, in the areas defined as introgression regions. In Asia, their shares declined (E) or vanished (A). Seven genetic populations of the Siberian roe deer, including two populations in the range of the European roe deer with the Siberian mtDNA lineage, were detected. Genetic diversity of mtDNA in the Siberian roe deer proved to be greater than it was documented earlier. Two ancient haplogroups, occurring predominantly in Europe, have been a remnant of the past natural interbreeding between the Siberian and the European roe deer that most probably had occurred hundred(s) kyr BP. Translocations of the Siberian roe deer to Eastern Europe performed in the 19th and 20th centuries have also left signals in the populations of the European roe deer.
Community perceptions of and preconditions for direct air capture in the U.S.
Authors: Scott-Buechler Celina , Osman Khalid , Ardoin Nicole , Fraser Catherine , Adcox Grace , Cain Bruce , Polk Emily , Jackson Robert 
Published: March 2023

Abstract
Direct air capture (DAC) has gained traction in climate policy as a promising method for carbon dioxide removal. How – and whether – DAC should be pursued as a climate strategy and deployed as local infrastructure, however, will rely on its ability to secure social license to operate (SLO), given the frequent disconnect between broad public perceptions of technologies and perceptions among host communities. There is also a growing need for the deployment of climate infrastructure like DAC to be responsive to environmental justice (EJ) and just transition (JT) principles. However, relatively little research exists on how communities may respond to DAC deployment locally, and the EJ and JT considerations they may evoke. In this study, we use a mixed-methods approach to evaluate public and community perceptions of DAC. We find that while communities may be generally open to the idea of DAC being deployed in their communities, the conditions under which DAC is realized are likely to determine levels of acceptance and support. The most important determinants of project support are community involvement in planning and implementation and expected benefits. This is perhaps especially important for infrastructure like DAC, which offers few if any direct local benefits (i.e., clean energy or air quality improvements). Building on recent trends, policies aimed at advancing DAC could include designated resources for community involvement and benefits in order to improve the likelihood of projects securing SLO and abiding by EJ and JT principles.
Predictors of mosquito bed net use among children under-fives in Ghana: A multilevel analysis of the 2019 malaria indicator survey
Authors: Aheto Justice Moses K. , Baba Rahmatu , Dzokoto Maxwell Kwame , Kwarah William , Alhassan Yakubu 
Published: March 2023

Abstract
Background
Morbidities and mortalities due to malaria can be prevented through the use of insecticide-treated mosquito bed nets (ITN) which has been proven for malaria control and elimination. The purpose of this study was to assess the critical factors that predict the use of ITN among children under-fives in Ghana.
Methods
The study utilized data from the 2019 Ghana Multiple Indicator Survey (MICS). The outcome variable was mosquito bed net use among children under-fives the previous night of the interview. To determine critical factors that independently predict ITN use, multilevel multivariable logistic regression was employed using Stata version 16. Odds ratios and their associated 95% confidence intervals and p-values were reported. A p < 0.05 was used to declare statistical significance.
Results
The overall prevalence of ITN usage was 57.4%. Utilization of bed nets was 66.6% in the rural areas and 43.5% in the urban areas, was highest in the Upper West region (80.6%) even when stratified to rural (82.9%) and urban areas (70.3%) whilst Greater Accra region (30.5%, rural = 41.7%, urban = 28.9%) had the least. The community level multilevel analysis showed that bed net utilization was higher among children in rural areas [AOR = 1.99, 95% CI = 1.32–3.01, p = 0.001] and in household with wooden wall materials [AOR = 3.29, 95% CI = 1.15–9.40, p = 0.027]. Bed net utilization was however, less for households with 3 + children under-five [AOR = 0.29, 95% CI = 0.19–0.46, p < 0.001), 4 years old (AOR = 0.66, 95% CI = 00.48–00.92, p = 0.014], those in the Greater Accra [AOR = 0.26, 95% CI = 0.13–0.51, p < 0.001], Eastern [AOR = 0.47, 95% CI = 0.23–0.95, p = 0.036], Northern [AOR = 0.42, 95% CI = 0.20–0.88, p = 0.022], middle [AOR = 0.57, 95% CI = 0.35–0.94, p = 0.026] and rich/richest [AOR = 0.51, 95% CI = 0.29–0.92, p = 0.025] household wealth quintile. Substantial unobserved household and community level differences in bed net use were found.
Conclusion
This study demonstrates the need to intensify promotion of ITN use to those in urban areas, Greater Accra, Eastern and Northern regions, houses without wooden wall materials, middle and rich/richest households. Interventions should be targeted at older children and households with more under-five children and to ensure full access and use of ITNs among all children under-fives in each household as part of the overall goal of achieving the health-related SDGs.
A Pyroptosis-Related Gene Prognostic Index For Hepatocellular Carcinoma
Authors: yu qian , Zhou Ruoyu , Yuan Hongjun , pang jianyu , Sheng Miaomiao , Luo Ying , Tang Wenru 
Published: March 2023

Abstract
Hepatocellular carcinoma, also known as HCC, is the third most common cancer-related cause of death globally. The specific prognostic model is crucial for HCC treatment strategies. Pyroptosis is a novel pathway for programmed cell death downstream of inflammasome activation. There are few prognostic evaluations of pyroptosis to HCC. In this work, 3 pyroptosis-related differentially expressed genes (DEGs) were found in 374 HCC patients and normal tissue from the TCGA database. These genes are BAX, GSDMD, and BAK1. Afterwards, based on the 3 DEGs with significant differences, we established 2 clusters by consensus cluster analysis. By using Cox univariate analysis, LASSO Cox regression analysis, and well-validated results from the ICGC cohort, we created a 7-gene risk pattern to further assess the prognostic usefulness of the genes connected to pyroptosis. Analysis of the Kyoto Encylopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) indicated unique metabolism-related pathways in the low- and high-risk groups. In addition, we discovered that the high-risk group had fewer immune cells and pathways that had been penetrated. We come to the conclusion that pyroptosis-related genes play significant roles in tumor immunity and can be used to forecast the prognosis of HCC.In order to identify viable medications, we also carried out batch molecular docking on thousands of interacting chemicals and prognostic molecules. We discovered Paclitaxel, Docetaxel, Dactinomycin, Ivermectin, and other medications from the docking data, and we also demonstrated the impact of their interactions.
Symptom Patterns of Comorbid Depression and Anxiety among Older Adults in China and Their Predictors: Latent Profile Analysis of a National Representative Sample
Authors: Yu Lingling , Chen Chuqian 
Published: March 2023

Abstract
Background
Comorbid depression and anxiety causes serious psychological and physiological damage for older people. This study aimed to identify heterogeneous classes of comorbid depression and anxiety (CDA) among older people in China and to ascertain predictors of latent class membership.
Methods
Cross-sectional data of 10919 cases were extracted from the Chinese Longitudinal Healthy Longevity Survey. Latent profile analysis (LPA) was used to identify symptom patterns of comorbid depression (measured by the 10-item Center for Epidemiologic Studies Depression Scale) and anxiety (measured by the Generalized Anxiety Disorder 7-item Scale). Multinomial logistic regressions following bivariate analyses were used to explore the relationship between the derived classes and the individual and social-level factors.
Results
Four patterns of CDA were identified: low symptoms of depression and anxiety (30.52%; n = 3333), mild depression only (53.26%; n = 5815), moderate depression and anxiety (13.82%; n = 1509), and severe depression and anxiety (2.40%; n = 262). Older people who are male, suffer from multimorbidity, and lack a healthy lifestyle are more likely to have problematic symptom profiles. While intimate relationships with partners and children significantly predicted CDA patterns, the effects of sibling relationships, daily life, or emotional support from the community were insignificant.
Conclusions
LPA identified four distinct CDA patterns among a representative sample of older Chinese people. While restless sleep, lack of positive emotions, uselessness, and weak concentration are salient across all profiles,‘difficult to relax’ is prominent in profiles high in anxiety. In addition to individual-level variables, social-level factors, especially intimate relationships with partners and children rather than general links to siblings or the community, have unneglectable impacts on whether and to what extent older Chinese adults suffer from CDA in the cultural context of relationism, patriarchy, and filial piety.
A Comparison of the Authoritarian Strategies Used by Brazil and Turkey to Tackle the COVID-19 Crisis
Authors: Kisa Adnan 
Published: March 2023

Abstract
Introduction

For authoritarian-minded leaders, the COVID-19 crisis offered a convenient pretext to silence critics and consolidate power. Populist and autocratic leaders used the crisis as an excuse to do things they had long planned to do but had not been able to.

Methods

Using a narrative literature review, this study examines the authoritarian responses to COVID-19 in Brazil and Turkey between 2020 and 2021. Available articles were retrieved from Medline and Google Scholar using a non-systematic approach using inclusion and exclusion criteria.

Results

Major identified authoritarian responses were imprisoning human rights defenders, journalists, lawyers, political activists, and medical professionals; flaunting public health and human rights laws; blaming other countries for causing the pandemic; and underreporting COVID cases.

Conclusion

The study concludes that these actions had devastating consequences for democracy, human rights, and public health.
Molecular typing and prognostic model of gastric cancer based on immunological signature gene sets
Authors: Yi Limu , Zhang Yan 
Published: March 2023

Abstract
BACKGROUND: The high incidence and mortality rates of gastric cancer posed a great challenge in its treatment. The principles of precision medicine called for improved staging diagnosis and prognosis assessment for better patient outcomes. Molecular staging of gastric cancer, based on the TCGA database, had gained significant attention. In this paper, we presented a novel approach to gastric cancer staging, utilizing the analysis of immunological signature gene sets expression across different samples, to construct a reliable prognostic model. Our findings provided a new tool for clinical management and treatment of gastric cancer.
METHODS: RNA expression data for gastric cancer tissue samples and normal samples were downloaded from the official websites of The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). The immunological signature gene sets were obtained from the Gene Set Enrichment Analysis (GSEA) database.
The RNA expression data was analyzed using various computational methods, including unsupervised clustering analysis, principal component analysis (PCA), and survival analysis. The unsupervised clustering analysis was used to divide the samples into three subtypes based on the expression of the immunological signature gene sets. PCA was performed to reduce the dimensionality of the data and identify the most informative genes. Survival analysis was used to identify the genes that were most strongly associated with patient prognosis. Based on the results of the analysis, we identified two gene sets that were strongly associated with patient prognosis. These gene sets were used to construct a prognostic model. The model was evaluated using various statistical methods, including receiver operating characteristic (ROC) curve analysis and Kaplan-Meier survival analysis. Finally, the biologically important functional pathways were analyzed using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and other databases. These analyses were used to identify the biological processes and pathways that were most strongly associated with the different subtypes of gastric cancer and the genes that were most important for patient prognosis.
RESULTS: Based on the expression of immunological signature gene sets in different samples, we classified the samples into three subtypes and validated them in the GEO downloaded samples. By analyzing clinical information, we identified 34 prognosis-related gene sets. After screening, we selected two gene sets (GSE21546_UNSTIM_VS_ANTI_CD3_STIM_DP_THYMOCYTES_UP, HALLMARK_ANGIOGENESIS) for model construction. The models were able to accurately predict the prognosis of the samples. Functional analysis revealed that the PI3K-Akt pathway might play a key role. Finally, we performed drug sensitivity analysis on the five core genes (SPP1, COL3A1, FGFR1, APOH and THBD) and identified piperlongumine and cerulenin as highly sensitive drugs.
Investigation and comparison of virulence factors (hydrophobicity, biofilm formation, ergosterol content, secretory enzymes) in Iranian clinical and environmental Candida albicans strains
Authors: Fatahinia Mahnaz , Molavinia Sahar , Seyedian Seyed Saeed , Amirrajab Nasrin 
Published: March 2023

Abstract
Background and objectives

Nowadays, candidiasis due to Candida species have become a worldwide health problem. The study aimed to detect and compare the prevalence of virulence factors of Candida albicans (hydrophobicity, biofilm formation, ergosterol content, secretory enzymes) isolated from clinical and environmental samples.

Materials and Methods

A total of 105 clinical and 165 environmental samples suspected of Candida albicans were collected from Imam Khomeini Hospital in Ahvaz, Iran. Isolates were assessed for five putative virulence factor production (ergosterol content, cell surface hydrophobicity, biofilm, protease, and phospholipase activity).

Results

The total of 60 Candida albicans isolates were identified: clinical (30/60) and environmental (30/60) C. albicans isolates. Biofilm production was observed in 100% of clinical and 80% of environmental C. albicans isolates (p < 0.001). In clinical and environmental C. albicans isolates, protease activity was 66.6% and 76.7%, respectively (p = 0.008). However, phospholipase activity was 60% and 76.7% in clinical and environmental C. albicans isolates, respectively (p = 0.262). The higher cell surface hydrophobicity in clinical isolates (66.4 ± 9.8) than in environmental C. albicans isolates (47.7 ± 17.0) was detected (p < 0.001). The ergosterol content in clinical and environmental C. albicans isolates was 1.2 (± 0.5) and 1.1 (± 0.3), respectively.

Conclusions

Based on the findings, biofilm formation was the stable characteristic of clinical, and phospholipase and proteinase activity was observed in most environmental C. albicans isolates. The results suggest that it is possible that cross-contamination between patients and the environment occurred because of the high similarity of virulence factors between clinical and environmental isolates.
Comparative analysis of DNA methylome reveals SUVH6 dependent non-CG DNA methylation and gene regulation potentially involved in Pi homeostasis in miR778-SUVH6 pathway in Arabidopsis
Authors: Wang Chaojun , Hao Bowen , Matnur Yusup , Sun Wei , Chen Weiqiang , Chen Yan 
Published: March 2023

Abstract
DNA methylation is one of the most important mechanisms for plant gene expression regulation to adapt to intra or extra environmental stimuli. Evidences indicate DNA CHG/CHH methylation and histone H3K9 methylation could reinforce each other and functionally interconnect. However, whether and how SUVH6 alone, a H3K9 methyltransferase, affects DNA methylation is not clear. Here, through comparative analysis of DNA methylomes of wildtype (WT) and SUVH6 mutant (suvh6), 478 hypo/116 hyper CHG differentially methylated regions (DMRs) and 5092 hypo/458 hyper CHH DMRs embedded in promoter, gene body and transposable element regions were identified, which indicates SUVH6 alone is required for maintaining non-CG methylation at specific regions of the Arabidopsis genome. Moreover, GO annotation reveals that, among 3299 SUVH6 potential target genes with their promoter or gene body overlapped with DMRs, 50 genes are involved in root development, 7 are associated with Pi transport, and 14 are related to phosphate (Pi) metabolism and membrane lipid remodeling. These results well coincide with the phenotype of miR778 overexpression line, which is to enhance primary root growth and increase shoot free Pi under Pi starvation. As miRNA778 targets SUVH6, the potential target genes involved in root development and Pi homeostasis identified here could be downstream of the miR778-SUVH6 pathway responsive to Pi starvation. All the above indicates that changes in DNA methylation can be applied to track SUVHs regulated gene expression.
A diatomaceous process leaches silica from silicate minerals, accounting for impure opal frustules
Authors: Akagi Tasuku , Welti Sophia , Tajiri Rei , Ishihara Takeshi , Shimada Kazuhiko 
Published: March 2023

Abstract
Dust is one of primary sources of new elements to oceanic water, but understanding of their dissolution behavior is still elusive1. Here we report evidence showing that diatoms are actively associated with the dissolution of silicate minerals. The cultivation of three diatom species was carried out with and without feldspar particles, albite and bytownite. Following cultivation, the girdles of Coscinodiscus frustules showed double Si peaks and the outer layers of the girdles showed significantly higher Al/Si ratios than the inner layers when feldspar particles were present. Feldspar particles showed rounded or fractured edges following the cultivation, which are not seen in the absence of diatoms. With presence of feldspar particles, significantly greater amounts of transparent exopolymer particles (TEP) were secreted after silicic acid concentration dropped almost to zero. A micro-fluorescence study revealed that the diatom cells actively lowered pH to keep the environment favorable to mineral dissolution by TEP. It is concluded that diatoms secrete TEP to digest feldspar and utilize silica, under conditions of silicic acid deficiency. The impurity of frustules is the reflection of such physiological activities. This finding reveals the presence of a previously unknown, yet important passage for elements to enter the oceanic system.