bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of chemical, nuclear, radiological medical training on first responders: dysfunctional heart rate variably leads to altered physiological and psychological response.
Authors: Giaume Louise , Roy Barbara Le , Jost Daniel , Cami Heloise Lauga , Travers Stephane , Trousselard Marion 
Published: January 2023

Abstract
Background: While professionals working in chemical, biological, radiological, and nuclear (CBRN) environments have underlined the need to improve the psychological and operational safety of personnel, there are few data regarding the stress induced in responders who must wear CBRN equipment. These conditions are particularly restrictive, both due to the risk of exposure to life-threatening toxic agents, and the need to wear equipment that places demand on their psychological, cognitive, and physiological capacities. Inter-individual variability remains poorly understood. Current research recognizes that the activity of the parasympathetic system (PSS) can be used as an objective marker of stress adaptation, measured as heart rate variability (HRV).
Methods:28 members of the Paris Fire Brigade medical team attended to three simulated scenarios requiring CBRN management of casualties. We examine: (i) anxiety, emotions, coping, body awareness, cognitive load, HRV, and exteroception impacts of working in CBRN environment; (ii) the role of PSS functioning in stress responses; and (iii) recovery. We recorded for three days: before the simulations (baseline), simulations’ day (pre- and post-training), and the following day.
Results show: (i) a high level of anxiety at baseline (Median 51 [46;56]) which decreased between pre- and post-training (p = 0.02); (ii) a post-simulation decrease in negative affect (p = 0.03); (iii) a tendency to decrease in body awareness during simulation (p = 0.06), which returned to the initial level at follow-up (p = 0.07); and (iv) decrease in mean RR between baseline and post-simulation n°1 (p = 0.04), and between baseline and post-training (p= 0.01). Clustering analysis based on the post-training median RMSSD: (i.e., stress-adapted subject versus non-stress-adapted subject) shows that stress-adapted subject tends to have more positive affect (p=0.006), a higher mean RR (p = 0.014) and SDNN (p = 0.005). The autonomic nervous system (ANS) shows different kinetics: the PSS activity increases post simulation in stress-adapted subject, and collapse between baseline, pre- and post-training in non-stress-adapted subject (p = 0.002). The sympathetic activity tends to increase in stress-adapted subject between baseline, pre- and post-simulation and tend to decrease in non-stress-adapted subject.
Conclusion: stress-adapted subject has a hardiness psycho-physiological response under CBRN stress.
Adsorption of Methylene Blue Dye from aqueous solution using low cost adsorbent: Kinetic, Isotherm Adsorption and Thermodynamic Studies
Authors: Al-Asadi Safaa Talib , Al-Qaim Fouad Fadhil 
Published: January 2023

Abstract
Fig leaf as an environmentally friendly byproduct of fruit plants, has been used for the first time to treatment of methylene blue dye. The fig leaf activated carbon (FLAC) was prepared successfully and used for adsorption of methylene blue dye (MB) purpose. The adsorbent was characterized by the Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscope (SEM) and the specific surface area by the Brunauer-Emmett-Teller (BET). In the present study, initial concentrations, contact time, temperatures, pH, carbon dose, volume solution and activation agent were covered. However, the initial concentration of MB was investigated at different concentrations 20, 40, 80, 120 and 200 mg/L. pH value was examined at these values (pH3, pH7, pH8 and pH 11). When pH is 11, the adsorption efficiency of MB retains at 84.3%. To determine how well FLAC removed MB, adsorption temperatures were changed at 20, 30, 40, and 50 °C. The adsorption capacity of FLAC was determined to be 22.7 mg/g for 0.08 g and 54.9 mg/g for 0.02 g. This adsorption inclined toward the Langmuir isotherm model (R2>0.95), where the adsorption created a monolayer covering the surface of the adsorbent, based on the curve-fitting using the Freundlich and Langmuir isotherm models. Additionally, it was discovered that the maximum adsorption capacity (Qm) was 69.93 mg/g and the Langmuir affinity constant (KL) was 0.08 L/mg. The FLAC as low-cost adsorbents for methylene blue dye has shown good cationic dye adsorption performance.
Modeling chronic pain experiences from online reports using the Reddit Reports of Chronic Pain dataset
Authors: Nunes Diogo A.P. , Ferreira-Gomes Joana , Neto Fani , de Matos David Martins 
Published: January 2023

Abstract
Purpose
Reveal and quantify qualities of reported experiences of chronic pain on social media, from multiple pathological backgrounds, by means of the novel Reddit Reports of Chronic Pain (RRCP) dataset, using Natural Language Processing techniques.
Methods
Define and validate the RRCP dataset for a set of subreddits related to chronic pain. Identify the main concerns discussed in each subreddit. Model each subreddit according to their main concerns. Compare subreddit models.
Results
The RRCP dataset comprises 86,537 Reddit submissions from 12 subreddits related to chronic pain (each related to one pathological background). Each RRCP subreddit has various main concerns. Some of these concerns are shared between multiple subreddits (e.g., the subreddit Sciatica semantically entails the subreddit backpain in their various concerns, but not the other way around), whilst some concerns are exclusive to specific subreddits (e.g., Interstitialcystitis and CrohnsDisease).
Conclusion
These results suggest that the reported experience of chronic pain, from multiple pathologies (i.e., subreddits), has concerns relevant to all, and concerns exclusive to certain pathologies. Our analysis details each of these concerns and their similarity relations. Although limited by intrinsic qualities of the Reddit platform, to the best of our knowledge, this is the first research work attempting to model the linguistic expression of various chronic pain-inducing pathologies and comparing these models to identify and quantify the similarities and differences between the corresponding emergent chronic pain experiences.
Association between ultra-processed food intakes with lipid profiles - A cross-sectional study
Authors: Nouri Mehran , Eskandarzadeh Sevda , Rajabzadeh-Dehkordi Milad , Omidbeigi Niloofar , Najafi Maryam , Faghih Shiva 
Published: January 2023

Abstract
The purpose of this cross-sectional study is to examine the association between UPFs intake level and lipid profile in Iranian people. This is a cross-sectional study which was performed on 236 individuals with the age range of 20 to 50 years in Shiraz, Iran. Food intakes of participants were evaluated by food frequency questionnaire (FFQ) which was previously validated in Iranian populations. For estimating the ultra-processed food, the classification of NOVA food group was used. Serum lipids including TC, TG, HDL-C and LDL-C were measured in blood samples. Logistic regression was used to evaluation the relation between UPF score and lipid profile. Higher UPFs intake was associated with increased OR of TG, LDL and HDL in both crude (OR: 2.60; 95% CI: 1.24–5.46 and OR: 2.05; 95% CI: 1.01–4.17 and OR: 4.34; 95% CI: 1.89–9.91 and adjusted model (OR: 2.76; 95% CI: 1.29–5.89 and OR: 2.08; 95% CI: 1.01–4.26 and OR: 4.91; 95% CI: 2.05–11.74). Thus, our results show significant associations between ultra-processed foods intake and dietary nutrient profiles that result in dyslipidemia as a risk factor of chronic diseases. In conclusion, UPF consumption worsen the nutritional profile of the diet and lead to negative changes in the lipid profile parameters.
The volatilome reveals toxicity, microbial composition, and indicators of ecosystem stress in a critical Oregon freshwater lake
Authors: Collart Lindsay , Jiang Duo , Halsey Kimberly 
Published: January 2023

Abstract
Toxins commonly produced by cyanobacterial blooms in freshwater lakes are a serious public health problem. The conditions leading to toxin production are currently unpredictable, thereby requiring expensive sampling and monitoring programs globally. We explored the potential of volatile organic compounds (VOCs) to indicate water toxicity and microbial community composition in Upper Klamath Lake, OR. Elastic net regularization regression selected 29 of 229 detected m/z + 1 values (corresponding to unique VOCs) in models predicting microcystin toxicity that outperformed or significantly improved upon regression models based on environmental parameters, such as chlorophyll, pH, and temperature. Several m/z + 1 values are tentatively identified as epinephrine pathway metabolites, indicating organismal stress associated with microcystin production. Unique sets of m/z + 1 values were also identified by elastic net regression that predicted the relative abundance of the most dominant bacterial phyla, classes, and cyanobacterial genera. These results show that VOCs may be a key component of lake monitoring strategies.
Comparison of the Performance of Two Rapid Immunochromatographic Methods for the Detection of Carbapenemase Genes among Carbapenem-Resistant Enterobacterales Clinical Strains
Authors: Liu Pingjuan , Deng Jiankai , Yi Siting , Ye Mengmin , Guo Penghao , Wu Zhongwen , Peng Yaqin , Huang Jianyu , cui Yingpeng , Huang Han , Chen Peisong , Liu Min , Liao Kang , Chen Yili 
Published: January 2023

Abstract
A rapid and accurate detection of carbapenemases for Enterobacterales isolates is crucial to the selection of antibiotics and the control of hospital infection. This study aimed to evaluate the performance of two immunochromatographic methods, NG-Test Carba 5 (Carba 5) and Goldstream Carbapenem-resistant K.N.I.V.O. Detection K-Set (K-Set), for detecting five major carbapenemases genes (blaKPC, blaNDM, blaIMP, blaOXA−48−like, and blaVIM). Carbapenemase genes were confirmed by PCR. In this study, 245 carbapenem-resistant Enterobacterales(CRE) strains were included, 96.7% of which produced carbapenemase. 58.2% of Klebsiella pneumoniae producing KPC carbapenemase was the most common CRE. NDM-producing Klebsiella pneumoniae accounted for 30.4%. Significantly, NDM-type are the primary carbapenemase among Escherichia coli and Enterobacter cloacae strains, accounting for 46 (93.9%) and 20 (83.3%) respectively. The performance of two methods showed excellent results in the carbapenemase detection with an overall specificity and sensitivity values both > 99%. Specially, one KPC-carbapenemase of K. pneumonia was accurately detected by the K-Set, but failed detected by Carba 5, since it harbored a novel blaKPC gene with a point mutation (A to G) at nucleotide position 787 compared with the blaKPC−33 gene. In conclusion, as simple, rapid and accurate diagnostic, these two methods are suitable for the carbapenemase genes detection in routine microbiology laboratories, providing an important basis for clinical rational selection of antibiotics.
Ovarian stimulation induced reduction of uterine NK cells proliferation and production of cytokines by perturbing estrogen signaling in mice
Authors: Ma Rong , Jin Ni , Lei Hui , Dong Jie , Xiong Yujing , Qian Chenxi , Chen Shuqiang , Wang Xiaohong 
Published: January 2023

Abstract
Background
Ovarian stimulation is associated with an increased incidence of abnormal placentation. Uterine natural killer (uNK) cells are the major subpopulation of decidual immune cells, which are crucial for placentation. In a previous study, we found that ovarian stimulation impairs uNK cell density on gestation day (GD) 8.5 in mice. However, it is not clear how ovarian stimulation led to a reduction in the density of uNK cells. In this study, we transferred blastocysts that were obtained from natural mating and in vivo development into individual pseudopregnant recipients produced by either natural mating (control group) or mating following ovarian stimulation (SO group).
Materials and Methods
Results
The fetal weights of the SO group were significantly lower than those of the control group on GD 18.5 (P < 0.001). In the SO placentas, PAS−positive area was significantly expanded (P < 0.05), and the micro vessel density values at the labyrinth zone were significantly reduced (P < 0.05). Notably, the density, maturity and cell proliferation activity of PAS+DBA+ uNK cells significantly declined in SO pregnant uteri compared with control, and the production of cytokines including IFN-γ, VEGF and PLGF of CD45+CD3−DBA+ uNK cells was also attenuated by ovarian stimulation. Additionally, we demonstrated that the production of chemokines and cytokines related to uNK recruitment, proliferation, and differentiation in the decidua is suppressed by ovarian stimulation.
Conclusion
we found that ovarian stimulation resulted in aberrant estrogen signaling and may contribute to the disorder of uNK cells caused by ovarian stimulation. Together, these results provided new insights on the mechanisms of aberrant maternal endocrine environments and abnormal placentation.
A Novel Mitochondria-Related Gene Signature in Esophageal Carcinoma: Prognostic, Immune, and Therapeutic Features
Authors: Zhang Xintong , Wu Hao , Niu Jingjing , Hu Yanfen , Zhang Wentao , Chang Jingjia , Li Li , Zhu Jianjun , Zhang Chunle , Liu Ming 
Published: January 2023

Abstract
Esophageal Carcinoma (ESCA) is a common and lethal malignant tumor worldwide. A role for mitochondria in tumorigenesis and progression has been proposed. The mitochondrial biomarkers were useful in finding significant prognostic gene modules associated with ESCA. In the present work, we obtained the transcriptome expression profiles and corresponding clinical information of ESCA from The Cancer Genome Atlas (TCGA). Differential expressed genes (DEGs) were overlapped with mitochondria related genes to obtain mitochondria related DEGs. The univariate cox regression, Least Absolute Shrinkage and Selection Operator (LASSO) regression, and multivariate cox regression was sequentially used to define the risk scoring model for mitochondria-related DEGs, and its prognostic value was verified in the external datasets GSE53624. Based on risk score, ESCA patients were divided into high and low risk groups. GO, KEGG and Gene Set Enrichment Analysis (GSEA) were performed to further investigate the difference between low and high risk groups in the gene pathway level. CIBERSORT was used to evaluate immune cell infiltration. The mutation difference between high and low risk groups was compared by the R package “Maftools”. Cellminer was used to assess the interactions of the risk scoring model and drug sensitivity. As the most important outcome of the study, we obtained 306 mitochondria related DEGs, and constructed a 6-gene risk scoring model (APOOL, HIGD1A, MAOB, BCAP31, SLC44A2 and CHPT1). Between high and low risk group, pathways including “hippo signaling pathway” and “cell-cell junction” was enriched. According to CIBERSORT, samples with high risk demonstrated higher abundance of CD4+ T cells, NK cells, M0 and M2 Macrophages, and lower abundance of M1 Macrophages. The immune cell marker genes were correlated with risk score. In mutation analysis, the mutation rate of TP53 was significantly different between the high and low risk groups. Drugs with strong correlation with model genes and risk score were selected. In conclusion, we focused on the role of mitochondria-related genes in cancer development, and proposed a prognostic signature for individualized integrative assessment.
Periodic Generalized Birkhoff Solutions and Farey Intervals for Monotone Recurrence Relations
Authors: Zhou Tong 
Published: January 2023

Abstract
The aim of this paper is to extend the results associated with periodic orbits from two-dimensions to higher-dimensions. Because of the one-to-one correspondence between solutions for the monotone recurrence relation and orbits for the induced high-dimensional cylinder twist map, we consider the system of solutions for monotone recurrence relations instead. By introducing intersections of type (k,l), we propose the definition of generalized Birkhoff solutions, generalizing the concept of Birkhoff solutions. We show that if there is a (p,q)-periodic solution which is not a generalized Birkhoff solution, then the system has positive topological entropy and the Farey interval of p/q is contained in the rotation set.
MSC: 37B40, 37C65, 37E40, 37E45.
Patients with Post-COVID-19 Vaccination Myocarditis Have More Favorable Strain in Cardiac Magnetic Resonance Than Those With Viral Myocarditis
Authors: Vaiyani Danish , Elias Matthew D. , Biko David M , Whitehead Kevin K , Harris Matthew A , Partington Sara L , Fogel Mark A 
Published: January 2023

Abstract
Introduction There have been reports of myocarditis following vaccination against COVID-19. We sought to describe cardiac magnetic resonance (CMR) findings among pediatric patients. Methods and Results Retrospective review at a large academic center of patients clinically diagnosed with post-vaccine myocarditis (PVM) undergoing CMR. Data collected included parametric mapping, ventricular function and degree of late gadolinium enhancement (LGE). Post processing strain analysis was performed using tissue tracking. Strain values, T1/T2 values and ventricular function were compared to age-and gender-matched controls with viral myocarditis using a Wilcoxon Signed Rank test. Among 12 patients with presumed PVM, 11 were male and 11 presented after the second vaccination dose, typically within 4 days. All presented with chest pain and elevated troponin. 10 met MRI criteria for myocarditis. All had LGE typically seen in the lateral and inferior walls; only five had prolonged T1 values. 10 met criteria for edema based on skeletal muscle to myocardium signal intensity ratio, and only 5 had prolonged T2 mapping values. Patients with PVM had greater short-axis global circumferential and radial strain, right ventricle function and cardiac output when compared to those with viral myocarditis. Conclusion Patients with PVM have greater short-axis global circumferential and radial strains compared to those with viral myocarditis. LGE was universal in our cohort. Signal intensity ratios between skeletal muscle and myocardium may be more sensitive in identifying edema than T2 mapping. Overall, the impact on myocardial strain by CMR is less significant in PVM compared to more classic viral myocarditis.
Cooperation in public goods game in populations of dynamic groups with varying evolution time scales
Authors: Xu Xin-Yun , Zhang Hong-Bin 
Published: January 2023

Abstract
The cooperation in a large population engaging in the Public Goods Game (PGG) is investigated. Agents have two strategies to choose, i.e., to cooperate or to defect. These agents are temporally formed into groups for playing the PGG. The group sizes are randomly distributed and the payoffs obtained by the two-type agents after playing the games are related to the strategy selection implemented by the death-birth process. The time scales between the interactions of the agents and the strategy update are also considered. We find that the frequency of cooperation as a function of the game parameter is greatly affected by the group size distributions and the time scales of the evolutionary dynamics. At some cases, the cooperative behavior can be analytically solved. In this model, a mixed state with coexistence of cooperators and defectors and a totally cooperative state are observed. The critical game parameter, above which a totally cooperative state will occur, is obtained by an analytical treatment or analyzed by the last-surviving pattern. When the process of the strategy selection is fast, the critical game parameter for the emergence of an AllC state depends on the size scope of the group size distribution and the time scale of the interactions via grouping dynamics. At slow strategy selection, the critical game parameter approaches to rely on the mean group size of the dynamically formed groups. All the theoretical results are verified by computer simulations and they are in a good agreement.
Schwartz Function Valued Solutions of the Euler and the Navier-Stokes Equations
Authors: Dio Philipp di 
Published: January 2023

Abstract
We prove the existence of a solution for the second order system of partial differential equations ∂tf = Δf + g . ∇f + h . f + k by a Montel space version of Arzelà--Ascoli and bound all Schwartz semi-norms. We find that for the Euler and the Navier--Stokes equations the vorticity remains a Schwartz function as long as the classical solution exists. Our approach is not affected by viscosity. It treats the hyperbolic Euler and the parabolic Navier--Stokes equation simultaneously.
2020 MSC: 35Q30, 76D03, 76D05
Unusual grafts for living-donor liver transplantation
Authors: Yim Seung Hyuk , Min Eun-Ki , Choi Mun Chae , Kim Deok Gie , Han Dai Hoon , Joo Dong Jin , Choi Jin Sub , Kim Myong Soo , Choi Gi Hong , Lee Jae Geun 
Published: January 2023

Abstract
Purpose: Unusual grafts, including extended left liver plus caudate lobe, right anterior section, and right posterior section grafts, are alternatives to left and right lobe grafts for living-donor liver transplantation. This study aimed to investigate unusual grafts from the perspectives of recipients and donors.
Methods: From 2016 to 2021, 497 patients received living-donor liver transplantation at Severance Hospital. Among them, 10 patients received unusual grafts. Three patients received extended left liver plus caudate lobe grafts, two patients received right anterior section grafts, and five patients received right posterior section grafts. Liver volumetrics and anatomy were analyzed for all recipients and donors. We collected data on laboratory examinations (alanine aminotransferase, total bilirubin, international normalized ratio), imaging studies, graft survival, and complications. A 1:2 ratio propensity score matching method was used to reduce selection bias and balance variables between the unusual and conventional graft groups.
Results: The mean model for end-stage liver disease score of unusual graft recipients was 18±9.64 and mean graft recipient weight ratio was 0.80±0.18. ABO incompatibility was observed in four cases. The alanine aminotransferase level, total bilirubin level, and international normalized ratio decreased in both recipients and donors. Unusual and conventional grafts had similar survival rates (p=0.492). The right and left subgroups did not differ from each counter-conventional sub-group (p=0.339 and p=0.695, respectively). The incidence of major complications was not significantly different between unusual and conventional graft recipients (p=0.513). Wound seromas were reported by unusual graft donors; the complication ratio was similar to that in conventional graft donors (p=0.169).
Conclusion: Although unusual grafts require a complex indication, they may show feasible surgical outcomes for recipients with a donor safety.