bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive evaluation of the implementation of close-type county medical alliance in Shandong Province using entropy weight TOPSIS method and non-integer rank sum ratio method
Authors: Zhang Qi , Lu Zhihong , Jing Shanshan , Guo Dong , Wang Lijun 
Published: April 2023

Abstract

Background
To improve the capacity of county medical and health services, China encourages all localities to pilot the close-type county medical alliance. In Shandong Province, medical alliances have been piloted in 47 counties, ranking first in the country. The objective of this study is to comprehensively evaluate the implementation of close-type county medical alliance in Shandong Province and provide a reference for the construction of a new county medical and health service system with clear goals, powers and responsibilities, and division of labor.
Methods
The implementation of the close-type county medical alliance was comprehensively evaluated in 47 national pilot counties in Shandong Province using entropy weight TOPSIS method and non-integer rank sum ratio method. Variance analysis was used for comparison of the comprehensive evaluation results.
Results
The weight coefficient of evaluation indicators was highest for information interconnection, at 18.06%, and lowest for orderly referral of patients, at 3.64%. There was no difference in results of the comprehensive evaluation of entropy weight TOPSIS method and non-integer rank sum ratio method. Comprehensively order the implementation status of each pilot county according to the relative paste progress, 13 counties Y5, Y11, Y14, Y16, Y20, Y25, Y26, Y27, Y28, Y32, Y33, Y40 and Y42 were ranked highest, whereas county Y37 was ranked lowest. Non-integer rank sum ratio method graded counties into three grades: excellent, good and average. Kruskal-Wallis nonparametric test showed that the difference between the grades was statistically significant (H=37.099, p <0.001). Variance analysis based on comprehensive evaluation results showed that implementation status was not correlated with the county economic development level, the level of health resources input and the medical service ability of the lead hospital.
Conclusions
Our findings indicated that the implementation of the close-type county medical alliance is significantly different between pilot counties, with a marked differentiation within the same urban area. Therefore, effective measures are recommended to reduce this gap, including promoting informatization empowerment of the county medical community, strengthening government responsibility and improving policy effectiveness.
Impact of an Okinawa/Nordic based diet on endocrinological and periodontal conditions in individuals with type 2 diabetes. A case-control study
Authors: Persson G. Rutger , Widén Cecilia , Wohlfart Björn , Sjöberg Klas , Steen Stig , Coleman Michael , Holmer Helene 
Published: April 2023

Abstract
Objectives To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D)(control group)Background Scientific evidence suggests that the use of diet for individuals with T2D may be beneficial.Methods Participating individuals with T2D were randomly assigned to a test (OBND)(n = 14), or control group (n = 16). Anthropometric data, blood glucose levels, HbA1c levels, lipids, serum inflammation markers (CRP, and a routine panel of 24 cytokines), blood pressure, gingival bleeding on probing (BOP), probing pocket depths (PPD), and clinical attachment levels (CAL) were studied.Results Statistical analyses of baseline study data failed to demonstrate study group differences. The mean weight reduction was greater in the OBND group (4.1 kg) versus the control group (1.3 kg) (p < 0.01). The reduction in BMI was 1.4 kg/m2 in OBND (p < 0.001) and 0.5 kg/m2 in the control group, respectively (p < 0.01). Diastolic and systolic blood pressure reductions were greater in the OBND group than in the control group (p < 0.01). Periodontal study parameters (BOP % scores) and (PPD values) decreased (p < 0.001) overall with no between group differences. The OBND resulted in reduction of serum levels of IFNγ, Eotaxin IL-9, IP10,IL17a, MCP-1,m and PDFBB compared to the control diet.Conclusions A strict T2D- diet provides an association between reduction in serum HbA1c and BOP scores. Serum levels decreases in IFNγ, Eotaxin IL-9, IP-10, IL17a. MCP-1, and PDFBB were only found in the test group.
Diagnosis and treatment of "chronic Lyme": primum non nocere. A review
Authors: Prat Sebastien , Dalbin Jacques , Plotton Catherine , Gocko Xavier 
Published: April 2023

Abstract
BACKGROUND: Approximately 10% of patients experience prolonged symptoms after Lyme disease. PTLDS (post treatment Lyme disease syndrome) is a controversial topic. It has been described as a source of overdiagnostic and off-label treatment. The objective of this work was to describe, in the context of the PTLDS, the diagnostic errors and adverse effects of drugs used outside the recommendations.
METHODS: systematic review of the literature according to PRISMA criteria, including randomized clinical trials (RCT), observational studies, and case reports addressing diagnostic errors and adverse events published between January 2010 and November 2020 in English or French.
RESULTS: 16 studies were included: 1 RCT, 7 observational studies and 8 case reports. In the 5 observational studies, overdiagnosis rates were very high, ranging from 80% to 100%. The new diagnoses were often psychiatric, rheumatological and neurological. Disorders with somatic symptoms were often cited. Diagnostic delays were identified for cancers and frontoparietal dementia. In the RCT and observational studies, prolonged anti-infective treatments were also responsible for adverse events, with emergency room visits and/or hospitalization. The most common adverse events were diarrhea, sometimes with Clostridium difficile colitis, electrolyte abnormalities, sepsis, bacterial and fungal infections, and anaphylactic reactions.
CONCLUSION: This review informs patients and physicians of the risks of prolonged anti-infective treatment that has not been proven to be beneficial. It does not seem ethical to offer such treatments to patients given the imperative of the "primum non nocere" principle of non-maleficence.
Early Healing Responses of Inflammatory Cells Following Maxillary Sinus Augmentation Using Platelet Rich Fibrin Bone Blocks
Authors: Yu Shimin , BD Yinping Tian , BD Yan Wei , BD Mengge Feng , BMed Sensen Li , BMed Guoyong Tong , BMed Zhouqing Yu , Miron Richard J. , Zhang Yufeng , Yang Zaibo B. , Wang Yulan L. 
Published: April 2023

Abstract
Objectives: The effects of horizontal platelet-rich fibrin (H-PRF) bone block on the healing and immune response during sinus augmentation have not been fully investigated histologically at early time points.
Materials and Methods: Eighteenth male New Zealand white rabbits underwent bilateral sinus augmentation and were divided into two groups: deproteinized bovine bone mineral (DBBM) alone and H-PRF + DBBM (H-PRF bone block) group. Maxilla samples were collected at 3, 7 and 14 days post sinus augmentation procedures and analyzed using histological staining for the number of inflammatory cells, new blood vessels and evidence for early osteoclast bone turnover/remodeling. Furthermore, the effects of H-PRF bone blocks on the migration of osteoblasts and THP-1 macrophages were evaluated using a Transwell assay in vitro.
Results:A higher number of immune cells were found in the H-PRF bone block group at 3 and 7 days post-surgery when compared to the DBBM alone group; most notably in the regions close to the mucosal lining and bone plates. Furthermore, a significantly greater number of new blood vessel formation and early signs of osteoclast development were found in the H-PRF bone block group at 14 days. The in vitro transwell assay further confirmed that culture medium from H-PRF bone block was able to markedly promote the migration of osteoblasts and THP-1 macrophages at early time points.
Conclusions:The findings from this study have shown that H-PRF bone block is capable of increasing early immune cell infiltration leading to the acceleration of neovascularization and speeding the process of bone metabolism in vivo following maxillary sinus grafting with DBBM.
Bi-axial shaking table tests to evaluate the seismic performance of two-story rammed-earth walls retrofitted with steel plates
Authors: Ruiz Daniel M. , Barrera Natalia , Reyes Juan C. , Alvarado Yezid A. , Villalba-Morales Jesús D. , Gómez Iván D. , Vacca Hermes A. , Beltrán Daniela Carrasco 
Published: April 2023

Abstract

Worldwide, unreinforced earthen buildings have shown poor performance during earthquakes, causing deaths and loss of property. The Spaniards that conquest the Americas built with earthen materials for about four centuries and therefore, there are a large number of historic buildings in the northern Andean zone of South America. This territory is geographically located in intermediate and high seismic hazard zones. Over the last few years, the authors proposed a seismic reinforcement system for historic earthen buildings based on A36 steel plates (100 mm x 6.35 mm) installed on both sides of the walls. However, to date, the studies had been focused on tests of one-story buildings subjected to in-plane pseudo-static loads or uniaxial dynamic loads. For this reason, this research assesses the seismic performance of two-story rammed-earth (RE) walls subjected to ground motions using a bidirectional shaking table. Two 1:2 scale RE walls (one retrofitted with steel plates and another unreinforced) were tested. The specimens were two-story walls with a "C" shape, similar to that found in heritage buildings of the Historic Center of Bogota (HCB). Based on the experimental tests, the unretrofitted wall presented irreparable damage at acceleration levels higher than 0.34g. In contrast, the retrofitted wall had excellent performance with lower damage levels and residual drifts; this specimen was highly resilient, withstanding earthquakes with peak ground acceleration (PGA) greater than 0.76g.
Accounting for clustering in automated variable selection using hospital data: A comparison of different LASSO approaches
Authors: Bollmann Stella , Groll Andreas , Havranek Michael 
Published: April 2023

Abstract
Background: Automated feature selection methods such as the Least Absolute Shrinkage and Selection Operator (LASSO) have recently gained importance in the prediction of quality-related outcomes as well as the risk-adjustment of quality indicators in healthcare. The methods that have been used so far, however, do not account for the fact that patient data are typically nested within hospitals.
Methods: Therefore, we aimed to demonstrate how to account for the multilevelstructure of hospital data with LASSO and compare the results of this procedure with a LASSO variant that ignores the multilevel structure of the data. We used three different data sets (from acute myocardial infarcation, COPD, and strokepatients) with two dependent variables (one numeric and one binary), on which different LASSO variants with and without consideration of the nested datastructure were applied. Using a 20-fold sub-sampling procedure, we tested the predictive performance of the different LASSO variants and examined differences in variable importance.
Results: For the metric dependent variable Duration Stay, we found that inserting hospitals led to better predictions, whereas for the binary variable Mortality, all methods performed equally well. However, in some instances, the variable importances differed greatly between the methods.
Conclusion: We showed that it is possible to take the multilevel structure of data into account in automated predictor selection and that this leads, at least partly, to better predictive performance. From the perspective of variable importance, including the multilevel structure is crucial to select predictors in an unbiased way under consideration of the structural differences between hospitals.
Dynamic Nonstationary Representations of a Railway Vehicle Considering Wheel Polygonalization under Variable Speed Conditions
Authors: Zhao Yue , Li Qiang , Yang Jianwei , Zhu Aihua , Wang Jinhai , Liu Changdong 
Published: April 2023

Abstract
Wheel Polygonalization is one of the most common failures of the wheelset, which can directly affect the safety and comfort of railway vehicle operation. In the actual condition, traction/braking torque continuously acts on the polygonal wheel fault can result in the modulation of its vibration representation, and then influence the effect of the feature exaction of the polygonal wheel faults. Considering this phenomenon, this study aims to clarify the forming mechanism of fault signals under variable speed conditions to improve the accuracy of feature extraction and ensure the safe operation of vehicles. This paper derived the Lagrangian equations with the dissipation function of a railway vehicle model with polygonal wheel fault under traction/braking conditions. After that, the modulation representation under constant speed, linear variable speeds, and nonlinear variable speeds are investigated, respectively. Finally, the vibration evolution of polygonal faults under different working conditions is visualized using statistical features. Compared with the constant speed, the curve in the time domain has more high-frequency fluctuations under variable conditions, and the phase modulation causes the half-wave asymmetry of the waveform. In the time-frequency domain, the continuous input of torque increases the harmonics frequency and side frequency response of fault response and excites the resonance frequency of the vehicle system. The dynamic evolution of fault statistical characteristics is positively correlated with speed and fault severity, and the fluctuation is sharper under braking conditions. The results can provide the theoretical support for feature extraction, interpretable features, and intelligent diagnosis of polygon faults.
Correlation between internal and external bony pelvis dimensions in nulliparous women
Authors: Hynčík Luděk , Jansová Magdalena , Němec Martin , Krofta Ladislav , Hympánová Lucie Hájková 
Published: April 2023

Abstract
Purpose: The study correlates internal and external bony pelvis dimensions of the birth canal to estimate the size and proportions of the birth canal.
Material and Methods: MRI (Magnetic Resonance Imaging) is used to identify the bony pelvis landmarks in 67 nulliparous women. The internal and external dimensions in the anterior-posterior and the transverse directions are calculated based on the landmarks and the correlation between them is set by means of the Pearson correlation coefficient ρ. The pelvic type estimation using the external bony pelvis dimensions is calculated.
Results: In the sagittal plane in the plane of inlet, the study shows a very strong correlation between APD (anterior-posterior diameter) and COE (conjugata obstetrica externa) (ρ = 0.8%) and between SCIPP (sacro-coccygeal inferior pubic point line) and DSB (distance between PSA and SJ), where PSA refers to the upper edge of the pubic symphysis and SJ refers to the sacro- coccygeal joint (ρ = 0.93%). In the transverse plane, there is a very strong correlation between TD (transverse diameter) and the average of DTI (distance between left and right tuber ischiadicum) and DBC (distantia bicristalis) (ρ = 0.8%). IPA (internal pubic angle) does not correlate strongly with any of the proposed dimensions. Finally, the correct estimation of the pelvic type is shown to be 63% using only the external dimension.
Conclusion: The study proves very strong correlations between the chosen internal and external pelvis dimensions in all major directions. However, the pelvic type estimation based on external dimensions is unclear.
A Comparative Study Between T Tube Drainage Vs Stent in Open Cbd Exploration
Authors: Mohammed Harsath , Fareed Rasik , C Ganga , R Janakiraman 
Published: April 2023

Abstract
Choledocholithiasis is presence of stones in common bile duct. Choledocholithiasis develops in about 10-15% of patients with gall stones. There are two methods for extracting CBD stones- Endoscopic retrograde cholangiopancreatography or surgically by CBD exploration. ERCP is preferred method in management of CBD stones .In patients where ERCP stone retrieval is contraindicated or failed ,surgical exploration is done .After open CBD exploration the CBD can be closed primarily without any stent after performing intra operative cholangiogram and confirming that there is no stones. If stones are identified or if intra operative cholangiogram is not available then CBD cannot be closed primarily where comes the role of stent or T Tube in the management. In our study, the outcomes of stent was compared with T tube drainage after open CBD exploration.The data gathered from the study population comprising of 40 patients was analysed with particular reference to the objectives of the study.As per study, we have taken 40 cases out of which T-tube were placed in 18 patients and Amsterdam stent were placed in 22 patients. Our results indicated that there is no difference in outcome.
Emerging resistome diversity in clinical Vibrio cholerae strains revealing their role as potential reservoirs of antimicrobial resistance
Authors: DE RITUPARNA , MUKHOPADHYAY ASISH K. , GHOSH MANISHA , BASAK SURAJIT , DUTTA SHANTA 
Published: April 2023

Abstract
Genotyping of Vibrio cholerae strains, VC1 and VC2 was undertaken to characterize antimicrobial resistance genes (ARGs) against chloramphenicol, SXT, nalidixic acid and streptomycin against which they were found to be resistant by antibiogram analysis. strAB, sxt, sul2, qace∆1-sul1 were detected by PCR. Genome annotation and identification of ARGs with WGS helped to detect the presence of almG, varG, strA (APH(3'')-Ib), strB (APH(6)-Id), sul2, catB9, floR, CRP, dfrA1 genes. Signatures of resistance determinants and protein domains involved in antimicrobial resistance, primarily, efflux of antibiotics were identified on the basis of 30%-100% homology to reference proteins. These domains were predicted to be involved in other metabolic functions on the basis of 100% identity with 100% coverage with reference protein and nucleotide sequences and were predicted to be of a diverse taxonomic origin accentuating the influence of the microbiota on AMR acquisition. Sequence analysis of QRDR (quinolone resistance-determining region) revealed SNPs. Cytoscape v3.8.2 was employed to analyse protein-protein interaction of MDR proteins, MdtA and EmrD-2, with nodes of vital AMR pathways. Vital nodes involved in efflux of different classes of antibiotics were found to be absent in VC1 and VC2 justifying the sensitivity of these strains to most antibiotics. The study helped to examine the resistome of VC isolated from recent outbreaks to understand the underlying reason of sensitivity to most antibiotics and also to characterize the ARGs in their genome. It revealed that VC is a reservoir of signatures of resistance determinants and serving as precursors for severe AMR crisis in cholera.
Primary diamond deposits of the Siberian craton: geology, petrology and mineralogy insights
Authors: Kostrovitsky Sergey , Iakovlev Dmitrii , Spetsius Zdislav , Garanin Konstantin 
Published: April 2023

Abstract
We provide general data on all the primary diamond deposits of Siberian craton, including the names of pioneers, the size of pipes, volume models for pipe bodies, interior features, and the diamond grade of kimberlites. The U-Pb ages of the deposits are within 350–370 Ma. The pipe's features are different by morphology, they may be both single-feeder and multi-feeder, with crater funnel-shaped expansion at the pipe tops, and subcylindrical having (starting from the surface) sub-vertical walls. The diamond grade gradually decrease from southern to northern deposits within Yakutian Province (the highest diamond grade for the Nakyn and Mirninsky fields, moderate for the Daldyn and Alakit-Markha fields, and relatively low being at the Upper Muna field occupying the most northern position as compared to with the other fields). The diamond grade of deposits correlates with the chemical composition of kimberlites. The highest diamond grade is noted at the Nyurbinskaya, Botuobinskaya Mayskaya, Internatsional'naya, and Aikhal pipes which are composed of high-Mg kimberlites. Most Yakutian deposits are composed mainly of volcanoclastic kimberlites that usually are higher diamond-grade, as compared with the coherent kimberlites. We discuss genetic issues of different morphology and multiphase composition of kimberlite pipes as well as rates for different intrusion phases and duration of pipe formation. The origin of some species of pyroclastic kimberlite is supposed to be related to the mantle depths.
In vivo successful repair of transplant renal artery aneurysm (TRAA) made possible in an Asian transplant unit.
Authors: Ho Collin Elijah Rui Hung , So Wei Zheng , Wong Julian , Tiong Ho Yee 
Published: April 2023

Abstract
Background Transplant renal artery aneurysm (TRAA) is rare. TRAA that develops post transplantation consists of 0.10% of the vascular complications post renal transplant. [1, 2]Case Presentation: We report a case of TRAA in an asymptomatic young female. CT angiogram with detailed 3D reconstruction showed a 2.6 x 2.2 cm wide neck saccular TRAA arising from the anterior segmental branch of the graft renal artery (Figs. 2 & 3). A multidisciplinary team of interventional radiologists, vascular and urologist was involved for preoperative surgical planning and unique repair methods. Endovascular and percutaneous approaches were deemed not feasible, and an open in vivo approach with a saphenous vein graft was taken.Conclusion TRAA, albeit rare, is a complication that can occur post renal transplant. In-vivo surgical repair of TRAA is feasible with a multidisciplinary approach and careful preoperative planning. Saphenous vein graft is still a versatile graft and can be used as a conduit successfully.
Impacts of climate disturbances on crop productivity in the flood zone of Santchou, western Cameroon
Authors: WAMBA Franck Robéan , ELONO Alvine Larissa MEYABEME , TSAFACK Honorine NTANGMO , YEMELI Élida Joëlle , TEMGOUA Émile 
Published: April 2023

Abstract
This work addresses the impacts of climate disturbances on agriculture in the Municipality of Santchou in western Cameroon. A total of 309 randomly sampled households were surveyed using a questionnaire, 17 community’s leaders were interviewed. Crop grow and agricultural systems were observed and describe directly in the field. Crop yields were obtained from the District Delegation of Agriculture and Rural Development (DAADR) of Santchou The results indicate that the increase in rainfall combined with drastic decreases in the number of rainy days caused flooding, leading to rotting of tubers and early harvests. There is also a proliferation of pests and parasites such as fall armyworms and Striga hermonthica, especially on maize, leading to a drop in yields of around 25 to 30% and a significant increase in prices products on the local market. The price per kilogram of maize, cassava, new cocoyam and sweet potato increases respectively from 95.67 francs, 64.17 francs, 82.83 francs and 83.50 francs in 2000 to 437.5 francs, 95.83 francs, 187.17 francs and 117.67 francs in 2010. In this context, it appears imperative to develop more appropriate adaptive strategies in order to reduce the vulnerability of farmers to climate disturbances.