bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsive Janus droplets as modular sensory layers for the optical detection of bacteria
Authors: Zeininger Lukas 
Published: July 2023

AbstractThe field of biosensor development is fueled by innovations in new functional transduction materials and technologies. Material innovations promise to extend current sensor hardware limitations, reduce analysis costs, and ensure broad application of sensor methods. Optical sensors are particularly attractive because they enable sensitive and noninvasive analyte detection in near real-time. Optical transducers convert physical, chemical, or biological events into detectable changes in fluorescence, refractive index, or spectroscopic shifts. Thus, in addition to sophisticated biochemical selector designs, smart transducers can improve signal transmission and amplification, thereby greatly facilitating the practical applicability of biosensors, which, to date, is often hampered by complications such as difficult replication of reproducible selector-analyte interactions within a uniform and consistent sensing area. In this context, stimuli-responsive and optically active Janus emulsions, which are dispersions of kinetically stabilized biphasic fluid droplets, have emerged as a novel triggerable material platform that provides as a versatile and cost-effective alternative for the generation of reproducible, highly sensitive, and modular optical sensing layers. The intrinsic and unprecedented chemical-morphological-optical coupling inside Janus droplets has facilitated optical signal transduction and amplification in various chemo- and biosensor paradigms, which include examples for the rapid and cost-effective detection of major foodborne pathogens. These initial demonstrations resulted in detection limits that rival the capabilities of current commercial platforms. This trend article aims to present a conceptual summary of these initial efforts and to provide a concise and comprehensive overview of the pivotal kinetic and thermodynamic principles that govern the ability of Janus droplets to sensitively and selectively respond to and interact with bacteria.
Graphical abstract
Postharvest monitoring and consumer choice on traditional and modern apricot cultivars
Authors: Taiti Cosimo , Vivaldo Gianna , Masi Elisa , Giordani Edgardo , Nencetti Valter 
Published: July 2023

AbstractApricot (Prunus armeniacaL.) fruit qualities are affected by harvest date and rapid off-tree ripening progression that limits their shelf life and marketability. Nowadays, consumers are generally dissatisfied with the sensory quality of apricot fruit sold on large-scale retail channels. Pomological analysis (color, firmness, total soluble solids, and total acidity), volatile organic compounds fingerprint and sensory evaluation were performed during the postharvest in two different apricot genotypes with the objective to: (1) characterize and compare two different apricot cultivars at harvest and at different postharvest times; (2) understand how the sensory quality changes during the postharvest process; (3) elucidate which sensory quality parameters drive the consumer's choice. For this purpose, ‘Portici’ (traditional cultivar) and ‘Lady Cot’ (modern one) grown in the same environment, were evaluated at commercial maturity harvest and for the following 15 days. Results indicate that the sensory quality of the selected cultivars was different, with ‘Portici’ showing better performances in terms of aroma, sweetness and juiciness, while ‘Lady Cot’ stood out in terms of firmness. Results also indicate a different trend of the traits analyzed and of the shelf-life, that was reduced for the traditional cultivar.Graphical abstract
Trends in use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) in Australia in the era of increased evidence of their cardiovascular benefits (2014–2022)
Authors: Lin Jialing , Pearson Sallie-Anne , Greenfield Jerry R. , Park Kyeong Hye , Havard Alys , Brieger David , Day Richard O. , Falster Michael O. , de Oliveira Costa Juliana 
Published: July 2023

Abstract
Purpose
To investigate trends in SGLT2i and GLP-1RA use in Australia in the era of increased evidence of their cardiovascular benefits.

Methods
We used national dispensing claims for a 10% random sample of Australians to estimate the number of prevalent and new users (no dispensing in the prior year) of SGLT2i or GLP-1RA per month from January 2014 to July 2022. We assessed prescriber specialty and prior use of other antidiabetic and cardiovascular medicines as a proxy for evidence of type 2 diabetes (T2D) and cardiovascular conditions, respectively.

Results
We found a large increase in the number of prevalent users (216-fold for SGLT2i; 11-fold for GLP-1RA); in July 2022 approximately 250,000 Australians were dispensed SGLT2i and 120,000 GLP-1RA. Most new users of SGLT2i or GLP-1RA had evidence of both T2D and cardiovascular conditions, although from 2022 onwards, approximately one in five new users of SGLT2i did not have T2D. The proportion of new users initiating SGLT2i by cardiologists increased after 2021, reaching 10.0% of initiations in July 2022. Among new users with evidence of cardiovascular conditions, empagliflozin was the most commonly prescribed SGLT2i, while dulaglutide or semaglutide was the most common GLP-1RA.

Conclusion
SGLT2i and GLP-1RA use is increasing in Australia, particularly in populations with higher cardiovascular risk. The increased use of SGLT2i among people without evidence of T2D suggests that best-evidence medicines are adopted in Australia across specialties, aligning with new evidence and expanding indications.
Rat bite fever mimicking ANCA-associated vasculitis
Authors: Błaż Aleksandra , Zalewski Jan , Masiak Anna , Kujawa Mariusz J. , Gosz Monika , Buda Natalia 
Published: July 2023

AbstractRat bite fever (RBF) is a rare infectious zoonotic disease caused by two bacterial species: the Gram-negative rod Streptobacillus moniliformis and the Gram-negative coiled rod Spirillum minus. The association between RBF and skin vasculitis and arthritis has been observed. The aim of this paper was to present a case of rat-bite fever with symptoms of skin vasculitis and arthritis, associated with high titers of ANCA antibodies and anti-endothelial cell antibodies suggestive of primary vasculitis. The patient was successfully treated with antibiotics and non-steroidal anti-inflammatory drugs, leading to significant improvement. Based on the presented case, we discuss the differential diagnosis of the signs and the role of infection in the induction of ANCA antibodies. We reviewed the English language literature for cases of RBF presenting with symptoms of vasculitis and/or antibody presence. A literature review was performed in PubMed and Google using the keywords “rat bite fever” AND “vasculitis”, “systemic vasculitis”, “ANCA”, “antiendothelial antibodies”. No cases of rat-bite fever with the presence of ANCA antibodies or AECA antibodies in its course have been described thus far. Rat bite fever is a rare disease with nonspecific symptoms. In its course, general weakness, intermittent fever, leukocytoclastic vasculitis, and arthritis are reported. To our knowledge, this is the first reported case of ANCA positivity associated with RBF.
Spectral Stability of Shock-fronted Travelling Waves Under Viscous Relaxation
Authors: Lizarraga Ian , Marangell Robert 
Published: July 2023

AbstractReaction-nonlinear diffusion partial differential equations can exhibit shock-fronted travelling wave solutions. Prior work by Li et al. (Physica D 423:132916, 2021) has demonstrated the existence of such waves for two classes of regularizations, including viscous relaxation (see Li et al. in Physica D 423:132916, 2021). Their analysis uses geometric singular perturbation theory: for sufficiently small values of a parameter $$\varepsilon > 0$$

ε
>
0

characterizing the ‘strength’ of the regularization, the waves are constructed as perturbations of a singular heteroclinic orbit. Here we show rigorously that these waves are spectrally stable for the case of viscous relaxation. Our approach is to show that for sufficiently small $$\varepsilon >0$$

ε
>
0

, the ‘full’ eigenvalue problem of the regularized system is controlled by a reduced slow eigenvalue problem defined for $$\varepsilon = 0$$

ε
=
0

. In the course of our proof, we examine the ways in which this geometric construction complements and differs from constructions of other reduced eigenvalue problems that are known in the wave stability literature.
Digital droplet PCR-based quantification of ccfHPV-DNA as liquid biopsy in HPV-driven cervical and vulvar cancer
Authors: Thangarajah Fabinshy , Busshoff Jana , Salamon Janina , Pruss Marie-Sandrine , Lenz Caroline , Morgenstern Bernd , Hellmich Martin , Schlößer Hans Anton , Lenz Maximilian , Domröse Christian , Mallmann Michael R. , Mallmann Peter , Weiß Jonathan , Franzen Fabian , Merkelbach-Bruse Sabine , Binot Elke , Eich Marie-Lisa , Büttner Reinhardt , Schultheis Anne Maria , Alidousty Christina 
Published: July 2023

Abstract
Purpose
More than 99% of cervical cancers and up to 40% of vulvar cancers are human papillomavirus (HPV) related. HPV 16 and 18 are the most relevant subtypes. Novel technologies allow the detection of minimal amounts of circulating cell-free HPV DNA (ccfHPV-DNA). The aim of this study was to evaluate ccfHPV-DNA assessed by droplet digital PCR (ddPCR) as a biomarker for molecular therapy monitoring in early, advanced, relapsed and metastatic HPV-driven cervical and vulvar cancer.

Methods
Inclusion criteria of the study were histologically proven HPV 16/18-driven cervical and vulvar cancer with first diagnosed disease, newly diagnosed recurrence, or progression of disease. Blood samples were taken pre- and post-therapeutically. Circulating cell-free HPV DNA was quantified using ddPCR and the results were correlated with clinical data.

Results
The mean copy number of ccfHPV-DNA was 838.6 (± 3089.1) in pretreatment and 2.3 (± 6.4) in post-treatment samples (p < 0.05). The copy number of ccfHPV-DNA increased with higher FIGO stages (p < 0.05), which are commonly used for clinical staging/assessment. Furthermore, we compared the distribution of copy numbers between T-stage 1 versus T-stage 2/3. We could show higher copy number level of ccfHPV-DNA in T-stage 2/3 (p < 0.05).

Conclusions
Therapy monitoring with determination of ccfHPV-DNA by ddPCR with a small amount of plasma reflects response to therapy and appears feasible for patients in advanced cancer stages of cervical and vulvar cancer. This promising tool should be examined as marker of therapy monitoring in particular in novel HPV-directed therapies.
Hyporeninemic hypoaldosteronism in RMND1-related mitochondrial disease
Authors: Kömhoff Martin , Gracchi Valentina , Dijkman Henry , Beck Bodo B. , Monnens Leo 
Published: July 2023

Abstract
Background
RMND1 is a nuclear gene needed for proper function of mitochondria. A pathogenic gene will cause multiple oxidative phosphorylation defects. A renal phenotype consisting of hyponatremia, hyperkalemia, and acidosis is frequently reported, previously considered to be due to aldosterone insensitivity.

Methods
Clinical features and pathophysiology of three patients will be reported. DNA of these patients was subjected to exome screening.

Results
In the first family, one pathogenic heterozygous and one highly probable heterozygous mutation were detected. In the second family, a homozygous pathogenic mutation was present. The electrolyte disbalance was not due to aldosterone insensitivity but to low plasma aldosterone concentration, a consequence of low plasma renin activity. This disbalance can be treated. In all three patients, the kidney function declined. In the first family, both children suffered from an unexplained arterial thrombosis with dire consequences.

Conclusions
Hyporeninemic hypoaldosteronism is the mechanism causing the electrolyte disbalance reported in patients with RMND1 mutations, and can be treated.
Japanese written pseudowords can be conditioned to Japanese spoken words with positive, negative, and active emotions
Authors: Ando Misa , Kambara Toshimune 
Published: July 2023

AbstractThis study aimed to examine whether Japanese participants condition spoken words’ meanings to written pseudowords. In Survey 1, we selected spoken words associated with negative (α = .91) and positive (α = .79) features for Experiment 1 and passive (α = .90) and active (α = .80) features for Experiment 2. In Experiment 1, participants evaluated four written pseudowords’ emotional valence using a 7-point semantic differential scale (1: negative; 7: positive) before and after conditioning spoken words with negative, neutral, or positive features to each pseudoword. In the conditioning phase, participants read each pseudoword, listened to a spoken word, and verbally repeated each spoken word. The results showed that a pseudoword was conditioned to spoken words with positive and negative features. In Experiment 2, participants evaluated four pseudowords’ activeness using a 7-point semantic differential scale (1: passive; 7: active) before and after conditioning spoken words of passive, neutral, and active features to each written pseudoword. In the conditioning phase, the participants read each written pseudoword, listened to a spoken word, and repeated the spoken word. The results showed that the activeness evaluations were more increased for pseudowords conditioned to spoken words of active and neutral features after conditioning than before conditioning but were unchanged for a pseudoword conditioned to those with passive features before and after conditioning. Additonally, Survey 2’s results showed that although the positiveness and activeness responses of the words used in Experiments 1 and 2 were controlled well, the lack of significant differences among positiveness responses of words may influence the evaluative conditioning in Experiment 2. That is, when participants condition passive (low arousal) words’ activeness (arousal) ratings to those of pseudowords, words’ positiveness (valence) ratings would be important in the evaluative conditioning. Our findings suggest that participants can condition spoken word meanings of preference and activeness to those of written pseudowords. It also indicates that linguistically evaluative conditioning’s effects are robust in a non-alphabetic language.
adaptNMT: an open-source, language-agnostic development environment for neural machine translation
Authors: Lankford Séamus , Afli Haithem , Way Andy 
Published: July 2023

AbstractadaptNMT streamlines all processes involved in the development and deployment of RNN and Transformer neural translation models. As an open-source application, it is designed for both technical and non-technical users who work in the field of machine translation. Built upon the widely-adopted OpenNMT ecosystem, the application is particularly useful for new entrants to the field since the setup of the development environment and creation of train, validation and test splits is greatly simplified. Graphing, embedded within the application, illustrates the progress of model training, and SentencePiece is used for creating subword segmentation models. Hyperparameter customization is facilitated through an intuitive user interface, and a single-click model development approach has been implemented. Models developed by adaptNMT can be evaluated using a range of metrics, and deployed as a translation service within the application. To support eco-friendly research in the NLP space, a green report also flags the power consumption and kgCO$$_{2}$$

2

emissions generated during model development. The application is freely available (http://github.com/adaptNMT).
Why to Study Peptides from Venomous and Poisonous Animals?
Authors: de Oliveira Ana Novo , Soares Andreimar Martins , Da Silva Saulo Luís 
Published: July 2023

AbstractVenom and poison peptides are powerful biological weapons and have proven immense pharmacological potential because of their high binding affinity to a wide range of molecular targets. Nonetheless, many of these peptides cannot directly be used as medicines due to their toxicity but their derivatives are very valuable to explore and can be a great treasure trove for the development of novel drugs. This review presents a detailed overview of venom peptides present in reptiles, amphibians, arachnids, gastropods, clitellatas, fish, insects, and mammals. We address the most recent findings that underline their therapeutic potential against a wide variety of diseases from cancer to vascular, autoimmune, and inflammatory diseases.

Graphical Abstract
The usefulness of the Munsell colour indices for identification of drained soils with various content of organic matter
Authors: Łachacz Andrzej , Załuski Dariusz 
Published: July 2023

Abstract
Purpose
The aim of the study was to determine the usefulness of the Munsell colour indices for identification of drained soils with various content of organic matter, developed on the sandy substrate.

Methods
The analysed soils, according to the Polish Soil Classification (PSC 2019), belong to thin murshic soils (WRB 2022: Murshic Histosols/Histic Gleysols), typical semimurshic soils (Mollic/Umbric Gleysols (Arenic, Drainic, Mulmic)) and to postmurshic soils (Umbric Gleysols (Arenic, Drainic, Nechic)). The following dry colour indices: value (V), chroma (Ch), V+Ch, V+0.5Ch, V×Ch and V/Ch, were correlated with soil variables (LOI, Corg., Ntot., C:N and FeHCl, MnHCl—elements extracted with 0.5 M HCl).

Results
The strongest correlation with the SOM content was displayed by the Munsell value, which allows one to estimate the SOM, Corg., Ntot. content in the soils studied. The classification and regression trees (C&RT) revealed that the analysed soil materials could be successfully divided based on the Munsell value alone. The V/Ch quotient demonstrated significant correlations with LOI, Corg., Ntot., C:N, FeHCl and MnHCl. This quotient equalled 1–2 for murshic (≥ 12% Corg.) and semimurshic (≥ 6.0 Corg. < 12.0%), but varied greatly (1–5) for postmurshic (≥ 0.6 Corg. < 6.0% Corg.) soil materials.

Conclusion
The analysed soil materials had the Munsell value differentiated enough to enable their identification. The V/Ch quotient can help to trace the origin of postmurshic soils. Its narrow value (1–2) indicates that the postmurshic soil developed through advanced transformation of murshic soil materials, whereas a broader value (2–5) indicates that the postmurshic soil originated from dewatered Gleysols.
The primacy of morphology in English braille spelling: an analysis of bridging contractions
Authors: Englebretson Robert , Holbrook M. Cay , Treiman Rebecca , Fischer-Baum Simon 
Published: July 2023

AbstractThis study examines the use of braille contractions in a corpus of spelling tests from braille-reading children in grades 1-4, with particular attention to braille contractions that create mismatches with morphological structure. Braille is a tactile writing system that enables people who are blind or visually impaired to read and write. In English and many other languages, reading and writing braille is not simply a matter of transliterating between print letters and their braille equivalents; Unified English Braille (the official braille system used in the United States, Canada, the United Kingdom, and several other English-speaking countries) contains 180 contractions—one or more braille cells that represent whole words or strings of letters. In some words, the prescriptive rules for correct braille usage cause contractions to bridge morphological boundaries and to obscure the spellings of stems and affixes. We demonstrate that, when the prescriptive rules for correct braille usage flout morphological structure, young braille spellers generally follow the morphology rather than the orthographic rules. This work establishes that morphology matters for young braille learners. We discuss the potential impact of our findings on braille research, development, and pedagogy, and we suggest ways in which our findings contribute to understanding the nature of orthographic morphemes and the place of braille in the reading sciences.
Experience matters for robotic assistance: an analysis of case data
Authors: Brian Riley , Oh Daniel , Ifuku Kelli Ann , Sarin Ankit , O’Sullivan Patricia , Chern Hueylan 
Published: July 2023

AbstractMany robotic procedures require active participation by assistants. Most prior work on assistants’ effect on outcomes has been limited in procedural focus and scope, with studies reporting differing results. Knowing how assistant experience affects operating room time could inform operating room case scheduling and provide an impetus for additional assistant training. As such, this retrospective cohort study aimed to determine the association between assistant experience and operating room time for 2291 robotic-assisted operations performed from 2016 to 2022 at our institution. Linear regression showed a significant association between the presence of a junior resident and increased case length differential with an increase of 26.9 min (p = 0.01). There were no significant associations between the presence of a senior resident (p = 0.52), presence of a fellow (p = 0.20), or presence of a physician assistant (p = 0.43) and case length differential. The finding of increased operating room time in the presence of a junior resident during robotic cases supports consideration of the adoption of formal assistant training programs for residents to improve efficiency.
A standardised communication tool reduces radiation exposure associated with intraoperative fluoroscopy
Authors: McAleese Timothy , Price Alexander , Ryan Anthony G. , Rowan Fiachra E. 
Published: July 2023

Abstract
Background
The widespread use of intraoperative fluoroscopy in orthopaedic procedures has revolutionised surgical practice. However, there are risks associated with using ionising radiation. Efforts to reduce radiation exposure include low-dose imaging protocols and lead protective equipment. Current communication during fluoroscopic procedures can be inefficient and lead to excessive radiation exposure for patients and staff.

Aims
This study aims to implement a communication tool with standardised commands to reduce radiation exposure in an Irish orthopaedic department.

Methods
Radiation exposure was evaluated using dose-area product (DAP) measured in uGy/m2. A control group was recorded before implementing the communication tool. Training sessions were conducted and posters of the standardised commands were displayed. Feedback was collected from surgeons and radiographers via surveys. Statistical analysis was performed to compare pre- and post-intervention groups.

Results
A total of 673 surgical cases were included over 6 months. The post-intervention group showed a mean reduction in radiation exposure from 59.8 to 36.4 uGy/m2 (p < 0.011). Subset analyses revealed reduced radiation exposure for ORIF of the distal radius, ankle, humerus, and phalanges. Surgeons and radiographers recognised the need for improved communication and expressed willingness to learn the new tool.

Conclusions
Implementation of a standardised communication tool effectively reduced patient and staff radiation exposure. It was also believed to have a positive effect on theatre staff morale. Incorporating a universal language tool into training programmes could be beneficial. Surgeons and radiographers provided several suggestions to improve the effectiveness and implementation of this tool into other units.