bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fenntartható élelmiszer-fogyasztással kapcsolatos fogyasztói megítélés feltárása netnográfiával
Authors: Balsa-Budai Nikolett , Szakály Zoltán 
Published: May 2023

A TANULMÁNY CÉLJA:
Jelen kutatás célja, hogy feltárja a hazai online fogyasztók fenntartható táplálkozással kapcsolatos attitűdjeit. Vajon a fogyasztók aktív szereplőként tekintenek-e magukra a probléma megoldásában, vagy inkább megfigyelőként az élelmiszeripart képviselő cégektől várják a megoldást? Melyek azok a lépések, amiket az elmúlt időszakban a fogyasztók megtettek a fenntartható élelmiszer-fogyasztás megvalósulásáért? Hogyan vélekednek a közelmúltban bevezetett vagy a jövőben tervezett élelmiszer-fogyasztáshoz kapcsolódó változásokról (pl. újféle csomagolóanyagok, csomagolásmentesség, egyszerhasználatos műanyag eszközök kivezetése, fenntarthatóbb étrend megvalósítása)?
ALKALMAZOTT MÓDSZERTAN:
A vizsgálat netnográfia segítségével került lebonyolításra, amely során az egyes, Magyarországon jelen levő és magyar Facebook-oldallal rendelkező cégek fenntartható táplálkozás kapcsán közzétett tartalmai és az ehhez kapcsolódó hozzászólások kerültek elemzésre.
LEGFONTOSABB EREDMÉNYEK:
Az eredmények egyrészről szemléltetik, hogy melyek a leggyakrabban felmerülő témakörök (növényi alapú étrend, élelmiszer-csomagolás) a fenntartható táplálkozás megvalósítása kapcsán. Emellett feltárásra került, hogyan vélekednek a hazai online fogyasztók a cégek által végzett, fenntarthatósággal kapcsolatos tevékenységekről, fejlesztésekről pl. új termékcsomagolás, innovatív (elsősorban vegán) élelmiszerek, környezetbarát megoldások. Továbbá melyek azok a vásárlást befolyásoló tényezők, amelyek valóban érvényesülnek az élelmiszer-fogyasztói magatartásban.
GYAKORLATI JAVASLATOK:
A szakirodalmi eredményekkel összhangban a netnográfia is igazolta, hogy a környezettudatos tényező az élelmiszerek esetében leginkább mint hozzáadott érték van jelen, a vásárlási döntést elsősorban az egészségtudatosság, a jó íz, a megbízható minőség és a megfelelő ár-érték arány befolyásolja. Így az élelmiszer-fogyasztás esetében a környezettudatosságot fontos, más tényezőkkel párosítani a marketingkommunikáció során, mint pl. az egészség, íz vagy az ár.
Agri-food firms’ attitude toward digital data exploitation in the product development
Authors: Frau Moreno , Keszey Tamara 
Published: May 2023

THE AIMS OF THE PAPER
This paper explores digital data exploitation behaviours and shows how these conducts change according to the data sources used by agri-food firms when developing their products.
METHODOLOGY
We adopt an exploratory multiple-case study to provide a theoretical framework for agri-food firms utilising digital data for product development.
MOST IMPORTANT RESULTS
The article shows two prominent firms’ behaviours that we labelled data explorers and data receivers and a third behaviour which is a combination of the main ones.
RECOMMENDATIONS
This article offers guidelines to support agri-food firms to distinguish how such firms may benefit from the digital transformation by gaining competitiveness improving production efficiency and supporting the development of their products.
Acknowledgments: This paper has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101030185. This article is an outcome of the project FooDization.
Társadalmi marketing a fenntarthatóság komplex rendszerében – kapcsolódó HR-kihívások
Authors: Klausmann-Dinya Anikó , Dinya László 
Published: May 2023

A TANULMÁNY CÉLJA
A fenntarthatósági kihívások figyelembevételének igénye egyre inkább előtérbe kerül a projekt-, település- és térségi szintű fejlesztési programok során. Minden helyi fejlesztési programban számolni kell annak az egész térséget érintő társadalmi – gazdasági – természeti környezetre gyakorolt hatásaira. És értelemszerűen kalkulálni kell nemcsak a gazdasági tőke, hanem a rendelkezésre álló (vagy esetleg akadályokat képező) humán-, szociális- és természeti tőke kívánatos fejlesztésével is, ha egy projektet hosszabb távon terveznek fenntartani. Tipikusan ilyenek például a turisztikai, energetikai, élelmiszerlánc fejlesztési programok. Bemutatni kívánjuk azt az általunk kidolgozott, és a gyakorlatban is alkalmazott fejlesztési modellt, amely ehhez tapasztalatunk szerint hasznos segítséget képes nyújtani. Fontos alapelv, hogy a társadalmi marketing és a HR-megfontolások nem mellőzhetők, amikor gyakran a humán/tudás/tőke, és/vagy a közösségi (szociális) tőke képezi egy-egy térségben a fejlesztéseket akadályozni képes szűk keresztmetszetet.
ALKALMAZOTT MÓDSZERTAN
A kidolgozott modell átfogó szakirodalmi szintézisen alapul, amelynek során érvényesítettük a gyakorlati alkalmazhatóság követelményeit is. A fejlesztéseket megalapozó helyszíni diagnózis a helyi adottságok öt pillérhez tartozó, összesen húsz legfontosabb tényező értékelését jelenti. Az értékelés helyi szakértők széles körének fókuszcsoportos megkérdezésével történik kérdőív segítségével. Ezt mutatjuk be, esettanulmány jelleggel.
LEGFONTOSABB EREDMÉNYEK
A kidolgozott modell gyakorlati alkalmazásának tapasztalatai meggyőzően igazolták, hogy a „best practice” (legjobb gyakorlat) preferálása komplex fenntarthatóság megvalósítását célzó projektek esetében nem lehetséges. Csak a helyi adottságokhoz illeszkedő diagnózisokon alapuló „good practices” (jó gyakorlatok) vezethetnek eredményre. Projektjeink kapcsán igazolást nyert tapasztalati tény, hogy a társadalmi marketing nélkülözhetetlen minden helyi fejlesztés esetén, amelynek köze van a fenntarthatósághoz, és a közösség bevonása, meg a humán (tudás) tőke egyidejű fejlesztése nélkül nem lehet eredményes. Márpedig a projektek döntő többsége ilyen, a jövőben pedig kifejezetten ilyen lesz.
GYAKORLATI JAVASLATOK
Az általunk kidolgozott és eredményesen alkalmazott modell hasznos segítséget nyújthat a helyi adottságok, lehetőségek és fenyegetések feltérképezéséhez fenntarthatóságot célzó helyi (térségi) fejlesztési projektek esetében. A társadalmi marketing és a HR-eszközök bevetése biztosíthatja, hogy a projekt nemcsak gazdaságilag, de társadalmilag és természeti környezeti szempontjából is hosszabb távon fenntartható lehet. Fontos feltétele, hogy a tervezésben, majd a megvalósításban ilyen szakértők is részt vegyenek.
Novel Evoked Synaptic Activity Potentials (ESAPs) Elicited by Spinal Cord Stimulation
Authors: Sharma Mahima , Bhaskar Vividha , Yang Lillian , FallahRad Mohamad , Gebodh Nigel , Zhang Tianhe , Esteller Rosana , Martin John , Bikson Marom 
Published: May 2023

AbstractSpinal cord stimulation (SCS) evokes fast epidural evoked compound action potential (ECAP) that represent activity of dorsal column axons, but not necessarily a spinal circuit response. Using a multimodal approach, we identified and characterized a delayed and slower potential evoked by SCS that reflects synaptic activity within the spinal cord. Anesthetized female Sprague Dawley rats were implanted with an epidural SCS lead, epidural motor cortex stimulation electrodes, an epidural spinal cord recording lead, an intraspinal penetrating recording electrode array, and intramuscular electromyography (EMG) electrodes in the hindlimb and trunk. We stimulated the motor cortex or the epidural spinal cord and recorded epidural, intraspinal, and EMG responses. SCS pulses produced characteristic propagating ECAPs (composed of P1, N1, and P2 waves with latencies <2 ms) and an additional wave (“S1”) starting after the N2. We verified the S1-wave was not a stimulation artifact and was not a reflection of hindlimb/trunk EMG. The S1-wave has a distinct stimulation-intensity dose response and spatial profile compared with ECAPs. 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX; a selective competitive antagonist of AMPA receptors (AMPARs)] significantly diminished the S1-wave, but not ECAPs. Furthermore, cortical stimulation, which did not evoke ECAPs, produced epidurally detectable and CNQX-sensitive responses at the same spinal sites, confirming epidural recording of an evoked synaptic response. Finally, applying 50-Hz SCS resulted in dampening of S1-wave but not ECAPs. Therefore, we hypothesize that the S1-wave is synaptic in origin, and we term the S1-wave type responses: evoked synaptic activity potentials (ESAPs). The identification and characterization of epidurally recorded ESAPs from the dorsal horn may elucidate SCS mechanisms.
Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive
Authors: Mackenbach Yarmo , Borst J. Gerard G. 
Published: May 2023

The medial superior olive (MSO) is a binaural nucleus that is specialized in detecting the relative arrival times of sounds at both ears. Excitatory inputs to its neurons originating from either ear are segregated to different dendrites. To study the integration of synaptic inputs both within and between dendrites, we made juxtacellular and whole-cell recordings from the MSO in anesthetized female gerbils, while presenting a “double zwuis” stimulus, in which each ear received its own set of tones, which were chosen in a way that all second-order distortion products (DP2s) could be uniquely identified. MSO neurons phase-locked to multiple tones within the multitone stimulus, and vector strength, a measure for spike phase-locking, generally depended linearly on the size of the average subthreshold response to a tone. Subthreshold responses to tones in one ear depended little on the presence of sound in the other ear, suggesting that inputs from different ears sum linearly without a substantial role for somatic inhibition. The “double zwuis” stimulus also evoked response components in the MSO neuron that were phase-locked to DP2s. Bidendritic subthreshold DP2s were quite rare compared with bidendritic suprathreshold DP2s. We observed that in a small subset of cells, the ability to trigger spikes differed substantially between both ears, which might be explained by a dendritic axonal origin. Some neurons that were driven monaurally by only one of the two ears nevertheless showed decent binaural tuning. We conclude that MSO neurons are remarkably good in finding binaural coincidences even among uncorrelated inputs.SIGNIFICANCE STATEMENTNeurons in the medial superior olive are essential for precisely localizing low-frequency sounds in the horizontal plane. From their soma, only two dendrites emerge, which are innervated by inputs originating from different ears. Using a new sound stimulus, we studied the integration of inputs both within and between these dendrites in unprecedented detail. We found evidence that inputs from different dendrites add linearly at the soma, but that small increases in somatic potentials could lead to large increases in the probability of generating a spike. This basic scheme allowed the MSO neurons to detect the relative arrival time of inputs at both dendrites remarkably efficient, although the relative size of these inputs could differ considerably.
Catastrophic ACTH-secreting pheochromocytoma: an uncommon and challenging entity with multifaceted presentation
Authors: Foppiani Luca , Poeta Maria Gabriella , Rutigliani Mariangela , Parodi Simona , Catrambone Ugo , Cavalleri Lorenzo , Antonucci Giancarlo , Del Monte Patrizia , Piccardo Arnoldo 
Published: May 2023

Summary
Cushing’s syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) by a pheochromocytoma is a challenging condition. A woman with hypertension and an anamnestic report of a ‘non-secreting’ left adrenal mass developed uncontrolled blood pressure (BP), hyperglycaemia and severe hypokalaemia. ACTH-dependent severe hypercortisolism was ascertained in the absence of Cushingoid features, and a psycho-organic syndrome developed. Brain imaging revealed a splenial lesion of the corpus callosum and a pituitary microadenoma. The adrenal mass displayed high uptake on both 18F-FDG PET/CT and 68Ga-DOTATOC PET/CT; urinary metanephrine levels were greatly increased. The combination of antihypertensive drugs, high-dose potassium infusion, insulin and steroidogenesis inhibitor normalized BP, metabolic parameters and cortisol levels; laparoscopic left adrenalectomy under intravenous hydrocortisone infusion was performed. On combined histology and immunohistochemistry, an ACTH-secreting pheochromocytoma was diagnosed. The patient's clinical condition improved and remission of both hypercortisolism and catecholamine hypersecretion ensued. Brain magnetic resonance imaging showed a reduction of the splenial lesion. Off-therapy BP and metabolic parameters remained normal. The patient was discharged on cortisone replacement therapy for post-surgical hypocortisolism. EAS due to pheochromocytoma displays multifaceted clinical features and requires prompt diagnosis and multidisciplinary management in order to overcome the related severe clinical derangements.

Learning points

A small but significant number of cases of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome are caused by ectopic ACTH secretion by neuroendocrine tumours, which is usually associated with severe hypercortisolism causing severe clinical and metabolic derangements.

Ectopic ACTH secretion by a pheochromocytoma is exceedingly rare but can be life-threatening, owing to the simultaneous excess of both cortisol and catecholamines.

The combination of biochemical and hormonal testing and imaging procedures is mandatory for the diagnosis of ectopic ACTH secretion, and in the presence of an adrenal mass, the possibility of an ACTH-secreting pheochromocytoma should be taken into account.

Immediate-acting steroidogenesis inhibitors are required for the treatment of hypercortisolism, and catecholamine excess should also be appropriately managed before surgical removal of the tumour.

A multidisciplinary approach is required for the treatment of this challenging entity.
Fish waste silage, a green process for low feedstock availability. A Review
Authors: Libonatti Claudia Carina , Agüería Daniela Alejandra , Breccia Javier 
Published: May 2023

Introduction. Different fishing activities generate a waste volume related to the processing species (viscera, heads and bones), the discards of the companion fauna, species of low commercial value and the losses related to handling problems. Fish meal production is the most common process for recovery nutrients from these fish processing byproducts. However, those places with reduced infrastructure or where the volume of wastes produced do not justified the economic equation for conversion into fish meal or oil, the biological silage could be the technology of choice to promote a sustainable waste management. Objective. To compilate, organize and summarize literature related to biological fermentation of fish waste and its applications. Development. A bibliographic review was carried out (January 1994 - December 2020) referring to the comprehensive use of fishing residues mainly focused on the use of lactic acid bacteria in fish waste fermentation. The information was organized in different sections: fish silage, lactic acid bacteria and carbohydrate sources for biological silage. Conclusions. The studies analyzed in this review highlight the possibility of using a wide variety of carbohydrate sources, biological starters and fish waste fermentation conditions. The satisfactory results show the potential use of fish waste in different applications. This work could contribute to the fisheries that decide to adopt this kind technology in order to provide an innovative and viable recycling bioeconomy.
Experimentos agrícolas con medidas repetidas en el tiempo: comparación entre estrategias de análisis
Authors: Vargas-Rojas Jorge Claudio , Vargas-Martínez Alejandro , Corrales-Brenes Eduardo 
Published: May 2023

Introducción. Diversas técnicas de modelación se han utilizado para analizar experimentos con medidas repetidas en el tiempo; no obstante, algunas de estas no son pertinentes en la actualidad. Objetivo. Comparar cuatro estrategias de análisis que se usan para analizar experimentos agrícolas con evaluaciones a través del tiempo. Materiales y métodos. Se utilizaron datos de un experimento donde se evaluó el efecto de distintas fuentes de fertilizante nitrogenado sobre el contenido de clorofila en un pasto forrajero a diferentes edades de cosecha. Estos datos se analizaron con cuatro estrategias: índice de área bajo la curva (IABC), análisis de la varianza multivariado (MANOVA), efecto aleatorio de la unidad experimental y modelación de la correlación temporal. Las dos últimas estrategias se realizaron bajo la teoría de modelos lineales mixtos; en estas se ajustaron diferentes modelos, todos con la misma estructura de efectos fijos, pero con diferentes efectos aleatorios, estructura de correlación residual o estructura de varianza residual. Mediante criterios de verosimilitud penalizada [criterio de información de Akaike (AIC) y criterio de información Bayesiano (BIC)] se eligió el modelo de mejor ajuste, con este se realizaron inferencias acerca de las medias de los efectos fijos que fueron significativos y se comparó con los resultados obtenidos de las estrategias IABC y MANOVA. Resultados. El modelo lineal mixto de mejor ajuste tuvo una estructura de correlación de simetría compuesta y varianza heterocedástica. Este modelo permitió analizar la interacción tratamiento × tiempo; por el contrario, tanto el MANOVA como el IABC, no permitieron analizar las tendencias temporales de los tratamientos. Conclusión. El modelo lineal mixto de mejor ajuste posibilitó seleccionar el mejor tratamiento en función del tiempo de evaluación. Por el contrario, tanto el MANOVA como el IABC condujeron a la selección de tratamientos que no fueron los mejores en todos los tiempos de evaluación.
West Nile virus infections in Hungary: Epidemiological update and phylogenetic analysis of the Hungarian virus strains between 2015 and 2022
Authors: Nagy Anna , Horváth András , Mezei Eszter , Henczkó Judit , Magyar Nóra , Nagy Orsolya , Koroknai Anita , Csonka Nikolett , Takács Mária 
Published: May 2023

AbstractFollowing the introduction of the West Nile virus (WNV) into Hungary in 2004, it has shortly become one of the most important human arbovirus infections, with a gradually increasing number of cases. The study aimed to summarize the current epidemiological situation in Hungary and sequence the WNV PCR-positive clinical specimens and virus isolates by next-generation whole genome sequencing (NGS) to obtain a detailed phylogenetic analysis of the circulating virus strains. Whole blood and urine samples from confirmed WNV-infected patients and WNV isolates were investigated by reverse transcription PCR assays. Genome sequencing was carried out by Sanger-method, followed by NGS on the Illumina MiSeq platform. Altogether 499 human infections were diagnosed between 2004 and 2022. A particularly remarkable increase in human WNV infections was observed in 2018, while the number of reported cases significantly decreased during the COVID-19 pandemic. Between 2015 and 2022, 15 WNV isolates, and 10 PCR-positive clinical specimens were investigated by NGS. Phylogenetic analysis revealed that the major European WNV lineage 2 clades, namely the Eastern European (or Russian) and the Central European (or Hungarian) clades, are presented in Hungary. Strains of the Balkan and other European clusters within the Central European clade are co-circulating in the country, following a characteristic geographical distribution. In Hungary, the presence and co-circulation of multiple lineage 2 WNV strains could be identified in the last few years. Therefore, in light of the 2018 WNV outbreak, sequence-based typing of the currently circulating strains could highly support outbreak investigations.
Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder
Authors: van Timmeren Tim , van Holst Ruth J. , Goudriaan Anna E. 
Published: May 2023

AbstractBackground and aimsDysfunction of the striatum, a brain region part of the mesolimbic reward system, is a key characteristic of addictive disorders, but neuroimaging studies have reported conflicting findings. An integrative model of addiction points to the presence or absence of addiction-related cues as an explanation for hyper- or hypoactivation, respectively, of the striatum.MethodsTo test this model directly, we investigated striatal activation during monetary reward anticipation in the presence versus absence of addiction-related cues using functional MRI. Across two studies, we compared 46 alcohol use disorder (AUD) patients with 30 matched healthy controls; and 24 gambling disorder (GD) patients with 22 matched healthy controls.ResultsDuring monetary reward anticipation, hypoactivation of the reward system was seen in AUD individuals compared to HCs. Additionally, a behavioral interaction was seen where gambling cues made participants, across groups, respond faster for bigger, but slower for smaller rewards. However, no striatal differences were seen in response to addiction-related cues between AUD or GD patients and their matched controls. Finally, despite substantial individual differences in neural activity to cue-reactivity and reward anticipation, these measures did not correlate, suggesting that they contribute independently to addiction aetiology.Discussion and ConclusionsOur findings replicate previous findings of blunted striatal activity during monetary reward anticipation in alcohol use disorder but do not support the idea that addiction-related cues explain striatal dysfunction as suggested by the model.
Effects of different modes and intensities of exercise on longevity proteins in middle-aged mouse skeletal muscle
Authors: Inoue Shota , Matsuura Kyohei , Eguchi Daisuke , Wakayama Masahiro , Ono Kosuke , Jiang Hanlin , Moriyama Hideki 
Published: May 2023

AbstractPhysical exercise represents one of the most effective approaches to anti-aging. The goal of this study was to verify the effects of different modes and intensities of exercise on longevity proteins in the skeletal muscle in midlife. Middle-aged mice were trained in aerobic or resistance exercise for 8 weeks, and the changes in sirtuin 1 (SIRT1), adenosine monophosphate-activated kinase (AMPK), and mammalian target of rapamycin (mTOR) pathways in the skeletal muscle were evaluated by western blotting. Long-term exercise had no effects on skeletal muscle SIRT1 abundance, whereas high-intensity aerobic exercise increased AMPK phosphorylation and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Low-intensity resistance exercise facilitated Akt/mTOR/p70 ribosomal protein kinase S6 (p70S6K) signaling but did not induce muscle hypertrophy. Conversely, high-intensity resistance exercise stimulated muscle hypertrophy without phosphorylation of mTOR signaling-related proteins. These results suggest the importance of setting exercise modes and intensities for anti-aging in midlife.