bluuebunny/crossref_metadata_2025_split huggingface dataset:
When space rules time: the Kappa effect with concurrent visual and tactile stimulation
Authors: De Pra Yuri , Catrambone Vincenzo , Wassenhove Virginie van , Valenza Gaetano , Bianchi Matteo 
Published: February 2023

Abstract
The spatial and temporal dimensions of a subjective experience are intertwined. In the Kappa effect, the spatial distance between consecutive visual stimuli proportionally influences the perceived duration of the inter-stimulus interval. Despite its relevance, to our knowledge no study has investigated such an illusory effect in concurrent multimodal perception through visual and tactile elicitations. To overcome this limitation, we characterise the Kappa effect on vision and somatosensation also through the assessment of duration perception in the sub-second range when sensory inputs are delivered on the palm or forearm using wearable devices. The effect of unimodal visual/tactile elicitations was also compared to several bimodal stimulations. Results showed that the illusory effect, which arose in both unimodal conditions, produces significantly higher distortions in vision. In the multimodal condition, when visual stimuli were at not-equidistant spatial locations, the integration with the tactile channel did not diminish the Kappa effect. Conversely, the Kappa effect vanished when the visual stimuli were at equidistant spatial locations, independently from the tactile stimuli location. These findings shed light on the human perceptual mechanisms, suggesting that the perceptual channel with lower variance in the spatial discrimination has a preeminent role in determining illusory perceptions in the time domain.
Evaluation of the susceptibility of Tritrichomonas foetus to extracts of Lantana camara (Verbenaceae) by flow cytometry
Authors: Lopez L A , Luque M E , Rivero M B , Abdala M E , Carranza P G , Luna B E , Lullo D Di , Volta B J , Rodriguez S A , Rivero F D 
Published: February 2023

Abstract
Bovine Trichomonosis (BT), a sexually transmitted disease endemic in countries with extensive cattle farming and natural service, is one of the most common causes of reproductive failure. 5-nitroimidazoles and their derivatives are used for its treatment, mainly metronidazole. The emergence of drug resistance mechanisms and treatment failures raise the need to investigate the effectiveness of new active compounds that contribute to parasite control. In this regard, extracts of Lantana camara (Verbenacea) have shown high biocidal potential against isolates of Trypanosoma cruzi and Leishmania braziliensis in vitro assays, although their effect on Tritrichomonas foetus has not been demonstrated yet. The available information on in vitro susceptibility of trichomonicidal drugs comes from the use of a diversity of methodologies and criteria, especially the observation of parasite motility under the optical microscope to assess their viability. Recently, in our laboratory, the use of flow cytometry has been described for the first time as a rapid and efficient method to evaluate the viability of T. foetus against metronidazole. The present study aimed to evaluate the cytostatic effect of L. camara extracts against T. foetus isolates by flow cytometry. Under aerobic conditions, IC50 values of 22.60 µg/mL were obtained on average. Under anaerobic conditions, the IC50 oscilated around 29.04 µg/mL. The results obtained allowed describing the susceptibility exhibited by these protozoa, being a valuable information for the development of potential BT treatments.
Beliefs About the Causes and Permanence of Depression in High-Symptom Adolescents: Correlates, Parent-Child Agreement, and Stability Over Time
Authors: Ahuvia Isaac L. , Schleider Jessica L. 
Published: February 2023

Abstract

Beliefs about the cause and timeline of depression inform how people manage depression and predict clinical outcomes. However, more research is needed to understand the relationship between these variables, especially among adolescents. We assessed causal and timeline beliefs in a sample ofN= 106 adolescents with elevated depression symptoms and their parents. Adolescents varied substantially in their endorsement of biological and external causes for depression, as well as in their beliefs about the timeline of depression. In contrast to prior research, we found that adolescents who held stronger biological causal beliefs also held stronger external causal beliefs (r= .39,p= .005). Moreover, neither causal beliefs were strongly linked with pessimistic timeline beliefs. Beliefs showed moderate stability across time, and adolescents’ beliefs did not correlate with those of their parents. We conclude that adolescents with elevated depression symptoms do not hold biological causal beliefs at the expense of other explanations.
WITHDRAWN: Functional network alterations in adult obstructive sleep apnea：A resting-state fNIRS study
Authors: Mingming Zhao , Wenhong Chen , xiaoying Mo , Jianrong Yang , Liu Howe , Lingli Shi , Hongwu Ma , Zhirong Jiang , Peiwen Zhang 
Published: February 2023

Abstract

Study Objectives: To evaluate brain network connectivity characteristics and complex network topology properties in adult with obstructive sleep apnea (OSA) based on functional near infrared spectroscopy (fNIRS). Methods Forty-five subjects including 22 with OSA and 23 healthy as the control were recruited for assessment of a 3-minute resting-state prefrontal cortex (PFC) activity with the fNIRS technique. Only the oxygenated hemoglobin(HbO2) signal was used to calculate resting-state functional connectivity (RSFC) and construct brain connection network. To better describe prefrontal connectivity, we also divided it into four types of connectivity (Short-1: intra-hemispheric connection within Regions of interest (ROIs); Short-2: intra-hemispheric connection between ROIs; Long-1: inter-hemispheric connection witnin ROIs; Long-2: inter-hemispheric connection between ROIs). We extracted the relevant indicators of brain network connection and the complex network based on graph theory, and then analyzed the correlation between the indicators and cognitive scale. Results Compared with the healthy control group, patients with OSA showed more chaotic connection patterns, weaker intra- and inter-hemispheric connection intensity, and lower integration efficient. Specifically, patients with OSA exerted significantly lower connection intensity and the total network edge numbers in all four connection types. Furthermore, the average correlation coefficient and global efficiency of brain network were positively correlated with Montreal Cognitive Assessment score. Conclusions The fNIRS-based brain functional connection and complex network topology properties in patients with OSA were significantly different from those in healthy subjects. Such differences based on the fNIRS technique could be considered as potential biomarkers for OSA diagnosis, assessment, and intervention.
Optimal nodes placement using a closed BCMP queueing network
Authors: Mizuno Shinya , Ohba Haruka 
Published: February 2023

Abstract
In this study, a closed BCMP queueing network, which is one of the most flexible queueing models relative to customer class and multiple service types that can be selected, was used for optimal node placement. Although the closed BCMP queueing network offers flexibility, it is computationally expensive when calculating performance evaluation quantities, such as the average number of customers in a system. Thus, the application of the closed BCMP to large-scale problems is considered challenging. In this study, an optimal node placement model, which uses a genetic algorithm to select the nodes where customers are not concentrated and are appropriately distributed, was implemented using a computational engine that calculated the performance evaluation quantity of a closed BCMP queueing network in real time. Two types of objective functions were designed: a penalty type, which applied a penalty when customers were concentrated at a node, and a variance type, which minimized the standard deviation of the average number of customers to equalize the average in the system. The features of this study, including the large-scale application of the closed BCMP queueing network and optimal node placement model, find application as a general-purpose model for node allocation planning in numerous situations and have high academic significance in the application of queueing theory to the real world.
Assessing the knee joint biomechanics and trunk posture according to medial osteoarthritis severity
Authors: Suzuki Yuki , Ohkoshi Yasumitsu , Kawakami Kensaku , Shimizu Kenta , Chida Shuya , Ukishiro Kengo , Onodera Tomohiro , Iwasaki Koji , Maeda Tatsunori , Suzuki Shoji , Kondo Eiji , Iwasaki Norimasa 
Published: February 2023

Abstract
Background
During progression of knee osteoarthritis (KOA), coronal, sagittal, and horizontal biomechanical parameters are dramatically altered. The purpose of this study is to assess the three-dimensional knee joint biomechanics and trunk posture according to KOA severity.
Methods
Seventy-five patients (95 knees) with medial knee osteoarthritis and 19 young healthy controls (38 knees) were enrolled in this study. The Kellgren-Lawrence classification was used for radiographic evaluation. There were 20 patients with 24 knees with grade 2, 25 with 28 knees with grade 3, and 30 with 43 knees with grade 4. All patients walked at a self-selected speed using an optical motion capture system. Additionally, six-degrees-of-freedom kinematics of the knee joint were calculated using the point cluster technique. The three moment components of the knee joint were calculated using inverse dynamics.
Results
In grade 2 KOA, the relative contribution of knee adduction moment (KAM) increased significantly, and that of knee flexion moment (KFM) decreased at the first peak of total joint moment prior to significant progression of varus knee deformity. Grade 3 KOA showed significant exacerbation of varus knee deformity and increased KA. Maximum knee extension angle decreased and trunk flexion increased during gait in grade 4 KOA.
Conclusions
We showed that kinetic conversion occurred in grade 2 KOA prior to varus deformity appearance as in grade 3. Knee flexion contracture and trunk flexion during gait occurred in grade 4 KOA. The relative contribution of KAM increased significantly, and that of KFM decreased prior to progression of varus knee deformity.
Trial registration:
Not applicable
Identification of FKBP1A associated DC cell infiltration as malignant predictor to prognosis in Glioblastoma
Authors: Xu Liming , Lin Baihua , Jia Yongshi , Xiong Hanchu 
Published: February 2023

Abstract
Purpose: FKBP1A is a member of the immunophilin protein family, which participates in basic cellular processes involving cell proliferation and immunity, especially interacting with rapamycin drug and mTOR protein. However, the relation between FKBP1A and clinical characteristics in glioblastoma (GBM)patients remains to be explored.
Methods
HPA, Prognoscan and GEPIA2 databases were used for data mining and analyzing FKBP1A, its co-expressed genes and dendritic cell (DC) related markers. TIMER2.0 database was used for analyzing the correlation and prognosis of FKBP1A and DC cells infiltration level in GBM.
Results
For the first time, we found that up-regulated FKBP1A expression and its co-expressed genes RPN2, DDOST and ITGB1 were correlated with GBM patients’ worse survival. Then, the oncogenic gene FKBP1A correlated with abundant infiltration of DC cell in GBM, the increase of DC marker NRP1 expression was also mined to be significantly correlated with worse survival in GBM. FKBP1A might play a role in the biological activity of protein N-linked glycosylation among GBM tumor microenvironment.
Conclusions
These findings infer that FKBP1A and its associated DC cell infiltration are significantly potential novel malignant prognostic indicators for GBM.
Evaluation of the histologic effects of injectable hyaluronic acid as a filler material in rat’s lip
Authors: Alaroomy Leena , AbdelBary Sawsan , El-Rouby Dalia , Alwadeai Mohamed , Ashoub Madiha 
Published: February 2023

Abstract
Background: Injectable hyaluronic acid is a type of temporary dermal filler. Hyaluronic acid is found naturally throughout the body, with the highest concentrations in the joints, eyes, and skin. Injectable hyaluronic acid is used to reduce the appearance of fine lines and wrinkles, facial folds, and to create structure, framework and volume to the face and lips.
Objectives: The present work aimed to examine the early and late histopathological changes occurring in the lower lips of rats, as a result of hyaluronic acid injection, and to determine whether it could really bring us closer to the ideal soft tissue filler material. This research highlights the importance of experimental studies on this subject, since adverse reactions have been observed routinely in dental practice.
Material and methods: The present study was carried out on 36 adult male albino rats with age ranging from 2 to 3 months and weight ranging from 150 to 200g. Rats were divided into two equal groups, each consisting of 18 rats; group I (control group) and group II (experimental group). Rats in the experimental group were injected with hyaluronic acid (0.07 ml), whereas rats in the control group were injected with 0.9% sodium chloride. Each group was further subdivided into 3 subgroups: A, B and C according to the time of sacrifice at one week, one and a half months and three months respectively.
Results: The results showed inflammation triggered by the injection of hyaluronic acid. On examining the specimens histologically using Hematoxylin and Eosin stains, Toluidine Blue stain and immunohistochemistry with anti-CD68 antibody, there was a significantly greater inflammatory response in the groups at early interval with hyaluronic acid compared with the control (P<0.0001). Higher collagen formation was also observed with Masson’s Trichrome staining.
Conclusion: Based on the histopathological, histochemical and immunohistochemical results of this study, undesirable effects of hyaluronic acid filler injection can be detected at early intervals following its injection. Fortunately, all the undesirable effects are transient and decrease by time, reaching levels comparable to normal. Overall, HA was well-tolerated by tissues, reflecting how this filler material possesses a biocompatible property.
International Practice Patterns of Dyslipidemia Management in Patients with Chronic Kidney Disease under Nephrology Care: Is it time to review guideline recommendations?
Authors: Calice-Silva Viviane , Muenz Daniel , Wong Michelle M.Y. , McCullough Keith , Charytan David , Reichel Helmut , Robinson Bruce , Stengel Benedicte , Massy Ziad A. , Pecoits-Filho Roberto 
Published: February 2023

Abstract
Background
In contrast to guidelines related to lipid therapy in other areas, 2012 Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend conducting a lipid profile upon diagnosis of chronic kidney disease (CKD) and treating all patients older than 50 years without defining a target for lipid levels. We evaluated multinational practice patterns for lipid management in patients with advanced CKD under nephrology care.
Methods
We analyzed lipid-lowering therapy (LLT), LDL- cholesterol (LDL-C) levels, and nephrologist-specified LDL-C goal upper limits in adult patients with eGFR < 60ml/min from nephrology clinics in Brazil, France, Germany, and the United States (2014–2019). Models were adjusted for CKD stage, country, cardiovascular risk indicators, sex, and age.
Results
LLT treatment differed significantly by country, from 51% in Germany to 61% in the US and France (p = 0.002) for statin monotherapy. For ezetimibe with or without statins, the prevalence was 0.3% in Brazil to 9% in France (< 0.001). Compared with patients not taking lipid-lowering therapy, LDL-C was lower among treated patients (p < 0.0001) and differed significantly by country (p < 0.0001). At the patient level, the LDL-C levels and statin prescription did not vary significantly by CKD stage (p = 0.09 LDL-C and p = 0.24 statin use). Between 7–23% of untreated patients in each country had LDL-C ≥ 160 mg/dL. Only 7–17% of nephrologists believed that LDL-C should be < 70 mg/dL.
Conclusion
There is substantial variation in practice patterns regarding LLT across countries but not across CKD stages. Treated patients appear to benefit from LDL-C lowering, yet a significant proportion of hyperlipidemia patients under nephrologist care are not receiving treatment.
IoT based Ground Water Level Monitoring System and Its Impact in Agricultural Applications
Authors: JAISUDHAN AZHAGU JAISUDHAN PAZHANI 
Published: February 2023

Abstract

The concept of a water level monitoring system is designed here. The proposed investigate microcontroller-based water level sensing and sound detection in a wireless context, as well as distance computation using an acoustic sensor. Residential electricity usage and water overflow could be reduced with the implementation of a water level monitoring method. It can also indicate that the sensor will detect water and that the water range will be displayed on the LCD if water is detected. Furthermore, cellular phones with a high-quality graphical user interface and a relatively high processing power have just become available. The utilization of such a valuable resource in a mobile application is required from the user's perspective. The suggested technology is a wireless groundwater monitoring system. Prototype sensor module that records and sends real-time groundwater level data from remote locations. It can be used for bore well and agriculture purposes. All data information is connected by the IoT (Internet of Things), a web- and cellular-based monitoring service protocol for calculating and sensing water levels. From the identified water, water quality and TDS have been measured for analyzing the quality levels of water.
Prediction of Air Quality Index (AQI) using Neural Approach
Authors: Singh Mayank Pratap , Chaturvedi D. K. 
Published: February 2023

Abstract
Air pollution has become a serious environmental issue. It is responsible for hundreds of fatalities each year and it poses a serious threat to human health and environment. It leads to global warming, greenhouse effect and it also causes respiratory problems like asthma, lung cancer etc. It is important to predict the quality of the air to regulate air pollution. In this paper, the neural approach is used in predicting the Air quality.
Comprehensive evaluation of similarity between synthetic and real CT images for nasopharyngeal carcinoma
Authors: Yuan Siqi , Chen Xinyuan , Liu Yuxiang , Zhu Ji , Men Kuo , Dai Jianrong 
Published: February 2023

Abstract
Background:
Although magnetic resonance imaging (MRI)-to-computed tomography (CT) synthesis studies based on deep learning have significantly progressed, the similarity between synthetic CT (sCT) and real CT (rCT) has only been evaluated in image quality metrics (IQMs). To evaluate the similarity between synthetic CT (sCT) and real CT (rCT) comprehensively, we comprehensively evaluated IQMs and radiomic features for the first time.
Methods:
This study enrolled 127 patients with nasopharyngeal carcinoma who underwent CT and MRI scans. Supervised-learning (Unet) and unsupervised-learning (CycleGAN) methods were applied to build MRI-to-CT synthesis models. The regions of interest (ROIs) included nasopharynx gross tumor volume (GTVnx), brainstem, parotid glands, and temporal lobes. The peak signal-to-noise ratio (PSNR), mean absolute error (MAE), root mean square error (RMSE), and structural similarity (SSIM) were used to evaluate image quality. Additionally, 837 radiomic features were extracted for each ROI, and the correlation was evaluated using the concordance correlation coefficient (CCC).
Results:
The MAE, RMSE, SSIM, and PSNR of the body were 91.99, 187.12, 0.97, and 51.15 for Unet and 108.30, 211.63, 0.96, and 49.84 for CycleGAN. For the metrics, Unet was superior to CycleGAN (p < 0.05). For the radiomic features, the percentage of four levels (ie, excellent, good, moderate, and poor, respectively) were as follows: GTVnx, 8.5%, 14.6%, 26.5%, and 50.4% for Unet and 12.3%, 25%, 38.4%, and 24.4% for CycleGAN; other ROIs, 5.44%± 3.27%, 5.56% ± 2.92%, 21.38% ± 6.91%, and 67.58% ± 8.96% for Unet and 5.16% ± 1.69%, 3.5% ± 1.52%, 12.68% ± 7.51%, and 78.62% ± 8.57% for CycleGAN.
Conclusions:
Unet-sCT was superior to CycleGAN-sCT for the IQMs. However, neither exhibited absolute superiority in radiomic features, and both were far less similar to rCT. Therefore, further work is required to improve the radiomic similarity for MRI-to-CT synthesis.
Trial registration:
This study was a retrospective study, so it was free from registration.
Association of ADC of hyperintense lesions on FLAIR images with TERT promotor mutation status in glioblastoma IDH wild type
Authors: Mastuda Ken-ichiro , Mitobe Yuta , Kanemura Yonehiro , Kanoto Masafumi , Futakuchi Mitsuru , Sonoda Yukihiko 
Published: February 2023

Abstract
Purpose: Although mutations in telomerase reverse transcriptase (TERT) promoter (TERTp) are the most common alterations in glioblastoma, predicting TERTp mutation status by preoperative imaging is difficult. We determined whether tumor-surrounding hyperintense lesions on fluid-attenuated inversion recovery (FLAIR) were superior to those of contrast-enhanced lesions (CEL) in assessing TERTp mutation status using magnetic resonance imaging (MRI).
Methods: This retrospective study included 114 consecutive patients with primary isocitrate dehydrogenase (IDH)-wild-type glioblastoma. Apparent diffusion coefficient (ADC) and volume of CELs and FHLs were determined, and the correlation between MRI features and TERTp mutation status was analyzed. In a subset of cases, FHLs were histopathologically analyzed to determine the correlation of tumor cell density and ADC.
Results: TERTp mutations were present in 77 (67.5%) patients. The minimum ADC of FHLs was significantly lower in the TERTp-mutant group than in the TERTp-wild-type group (mean, 961.0 × 10−3 and 1159.9 × 10−3 mm2/s, respectively; P < 0.01). However, other MRI features such as CEL and FHL volumes, minimum ADC of CELs, and FHL/CEL ratio, were not significantly different between the two groups. Histopathologic analysis indicated high tumor cell density in FHLs with low ADC.
Conclusion: The ADC of FHLs was significantly lower in IDH-wild-type glioblastoma with TERTp mutations, suggesting that determining the ADC of FHLs on preoperative MRI might be helpful in predicting TERTp mutation status and surgical planning.
Regularity of the equilibrium measure for meromorphic correspondences
Authors: Dinh Tien-Cuong , Wu Hao 
Published: February 2023

Abstract
Let f be a meromorphic correspondence on a compact Kahler manifold X of dimension k. Assume that its topological degree is larger than the dynamical degree of order k - 1. We obtain a quantitative regularity of the equilibrium measure of f in terms of its super-potentials.
Classification AMS 2020: 32H, 37F05, 32U40.