bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magmatic source, petrogenesis, and tectonic setting of the Concepción del Oro Igneous Complex: a geochemical and isotopic (Rb–Sr and Sm–Nd) study of a late complex of the Cretaceous–Eocene Mexican Magmatic Arc
Authors: González-Guzmán Reneé , Velasco-Tapia Fernando , Weber Bodo , Schaaf Peter , Sosa-Valdés Rogelio , Solari Luigi 
Published: May 2023

AbstractDuring the Mexican fold-and-thrust belt tectonics, the inboard migration of long-term cordilleran magmatism typifies the geological setting during the Cretaceous–Paleogene period. The Concepción del Oro Igneous Complex (COIC) represents one of the most internal and isolated magmatic pulses that occurred during this magmatic activity. In this work, plutonic rocks from the COIC were studied using petrography, U–Pb geochronology, whole rock and zircon geochemistry, and Rb–Sr and Sm–Nd isotopes. Petrographic observations reveal mainly fine-to-coarse-grained granodioritic composition for most plutonic masses. U–Pb zircon analyzes of four samples from the largest plutonic center of the COIC yielded ages ranging from 42.6 ± 0.2 Ma to 41.8 ± 0.1 Ma. The granodiorites exhibit geochemical features typical of I-type, high-K calc-alkaline, Magnesian rocks. The chondrite-normalized REE diagram summarizes enrichment of LREE ([La/Yb]N = 5.94–19.19) and moderate to slightly negative Eu anomalies (Eu/Eu* = 0.63–0.94). In addition, the mantle-normalized spider diagram shows enrichment of LILE, such as Rb and Ba, and depletion of HFSE, such as Nb, Ta, Ti, and P. Whole-rock and zircon geochemistry indicate a post-collisional setting with an inherited magmatic arc fingerprint. Ti-in-zircon temperatures and zircon saturation thermometry suggest a magmatic origin from evolved and relatively cold melts (~ 700 °C). Moreover, the systematic variations in the ratios of highly incompatible elements, such as La/Sm (6.54–3.79) and Rb/Sr (0.32–0.10), and relatively narrow ranges in Zr/Hf (36.25–48.84) and147Sm/144Nd (0.0941–0.1261), suggest fractional crystallization as the main petrogenetic process involved in the formation of the COIC rocks. Whole-rock isotopic data suggest a magma source mixing juvenile material with older continental crust, as indicated by87Sr/86Sr(t= 40)ratios between 0.704583 and 0.707783,143Nd/144Nd(t= 40)ratios varying in the ranges of 0.512478–0.512702 (εNd(t= 40) = from + 2.18 to − 2.10), and TDM(Nd)ranging from 1.03 to 0.62 Ga. We conclude that the parental source of the COIC was derived from partial melting of the lower crust triggered by emplacement of an underplated magma at the base of the crust during the end of an orogenic cycle.
Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis
Authors: Castellar-Mendoza Camilo , Castillo Diana Marcela , Chila-Moreno Lorena , Bautista-Molano Wilson , Romero-Sánchez Consuelo 
Published: May 2023

Abstract
Introduction
Porphyromonas gulae have the enzyme PPAD, as P. gingivalis, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between P. gulae PPAD in rheumatoid arthritis (RA).

Objective
To assess the presence of P. gulae and anti-citrullinated peptide antibodies of P. gulae PAD in patients with RA and their possible relationship with clinical activity markers.

Subjects and methods
A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) were measured. Activity index-28 (DAS28) and SCDAI. The periodontal diagnosis was established. Presence of P. gulae and P. gingivalis. An ELISA was used to determine antibodies against citrullinated peptides of P. gulae PAD.

Results
A P. gulae frequency of 15.8% was observed in the RA group and 9.5% in the control group. Higher levels of ACPA were found in the P. gulae-positive patients of the RA group, finding no significant difference, but if in patients positive for P. gingivalis with statistical significance (p = 0.0001). The frequency of anti-VDK-cit and anti-LPQ-cit9 antibodies to PPAD of P. gulae was higher in the RA group than in the control group without significant difference. No relationship was found with the clinical variables despite the presence of P. gulae and anti-citrullinated peptide antibodies of P. gulae PPAD in patients with RA

Conclusions
It was not possible to establish a connection with clinical variables in RA and P. gulae; as a result, the presence of P. gingivalis continues to contribute significantly to the increase in antibodies against citrullinated proteins/peptides from exogenous sources of citrullination in RA and periodontitis.
Surgical management of perianal fistula using an ovine forestomach matrix implant
Authors: Hsu A. , Schlidt K. , D’Adamo C. R. , Bosque B. A. , Dowling S. G. , Wolf J. H. 
Published: May 2023

Abstract
Purpose
Invasive surgical management of cryptoglandular perianal fistulas (PF) is challenging because of high recurrence rates and the potential for injury to the sphincter complex. In the present technical note, we introduce a minimally invasive treatment for PF using a perianal fistula implant (PAFI) comprising ovine forestomach matrix (OFM).

Methods
This retrospective observational case series highlights 14 patients who had undergone a PAFI procedure at a single center between 2020 and 2023. During the procedure, previously deployed setons were removed and tracts were de-epithelialized with curettage. OFM was rehydrated, rolled, passed through the debrided tract, and secured in place at both openings with absorbable suture. Primary outcome was fistula healing at 8 weeks, and secondary outcomes included recurrence or postoperative adverse events.

Results
Fourteen patients underwent PAFI using OFM with a mean follow-up period of 37.6 ± 20.1 weeks. In follow-up, 64% (n = 9/14) had complete healing at 8 weeks and all remained healed, except one at last follow-up visit. Two patients underwent a second PAFI procedure and were healed with no recurrence at the last follow-up visit. Of all patients that healed during the study period (n = 11), the median time to healing was 3.6 (IQR 2.9–6.0) weeks. No postprocedural infections nor adverse events were noted.

Conclusions
The minimally invasive OFM-based PAFI technique for PF treatment was demonstrated to be a safe and feasible option for patients with trans-sphincteric PF of cryptoglandular origin.
Constituent-based quasi-linear viscoelasticity: a revised quasi-linear modelling framework to capture nonlinear viscoelasticity in arteries
Authors: Giudici Alessandro , van der Laan Koen W. F. , van der Bruggen Myrthe M. , Parikh Shaiv , Berends Eline , Foulquier Sébastien , Delhaas Tammo , Reesink Koen D. , Spronck Bart 
Published: May 2023

AbstractArteries exhibit fully nonlinear viscoelastic behaviours (i.e. both elastically and viscously nonlinear). While elastically nonlinear arterial models are well established, effective mathematical descriptions of nonlinear viscoelasticity are lacking. Quasi-linear viscoelasticity (QLV) offers a convenient way to mathematically describe viscoelasticity, but its viscous linearity assumption is unsuitable for whole-wall vascular applications. Conversely, application of fully nonlinear viscoelastic models, involving deformation-dependent viscous parameters, to experimental data is impractical and often reduces to identifying specific solutions for each tested loading condition. The present study aims to address this limitation: By applying QLV theory at the wall constituent rather than at the whole-wall level, the deformation-dependent relative contribution of the constituents allows to capture nonlinear viscoelasticity with a unique set of deformation-independent model parameters. Five murine common carotid arteries were subjected to a protocol of quasi-static and harmonic, pseudo-physiological biaxial loading conditions to characterise their viscoelastic behaviour. The arterial wall was modelled as a constrained mixture of an isotropic elastin matrix and four families of collagen fibres. Constituent-based QLV was implemented by assigning different relaxation functions to collagen- and elastin-borne parts of the wall stress. Nonlinearity in viscoelasticity was assessed via the pressure dependency of the dynamic-to-quasi-static stiffness ratio. The experimentally measured ratio increased with pressure, from 1.03 $$\pm$$
±
0.03 (mean $$\pm$$
±
standard deviation) at 80–40 mmHg to 1.58 $$\pm$$
±
0.22 at 160–120 mmHg. Constituent-based QLV captured well this trend by attributing the wall viscosity predominantly to collagen fibres, whose recruitment starts at physiological pressures. In conclusion, constituent-based QLV offers a practical and effective solution to model arterial viscoelasticity.
Simulating the entire rainfall-induced landslide process using the material point method for unsaturated soil with implicit and explicit formulations
Authors: Yamaguchi Yuya , Makinoshima Fumiyasu , Oishi Yusuke 
Published: May 2023

AbstractRainfall-induced landslides cause various types of damage, including damage to infrastructure, leading to devastating economic losses and human casualties. Although various numerical methods have been developed to predict landslide occurrence and the extent of sediment flow, three-dimensional analysis of the entire landslide process in a unified manner is still challenging owing to limitations in computational efficiency and the representation of deformation and flow. In this study, we present a numerical method of rainfall-induced landslides using the coupled hydromechanical material point method (MPM) for unsaturated porous media based on implicit and explicit formulations, which enables the efficient analysis of all rainfall-induced landslide processes, including both quasi-static and dynamic processes. The developed method includes an implicit MPM based on a simplified formulation, which is first applied to the quasi-static analysis in the pre-failure stages in which rainwater infiltrates the ground. The explicit MPM is then applied to the dynamic analysis for post-failure stages in which the ground collapses and flows. A constitutive law for soils is improved in the simulation of landslide initiation and sediment flow by incorporating the effect of cohesion in a visco-plastic model for granular materials. The proposed method was applied to a three-dimensional terrain model of Ashikita town, Kumamoto, Japan, where an actual landslide occurred owing to intense rainfall on July 3–4, 2020. Numerical results from the proposed hydromechanical coupling compared with single-phase MPM indicated that pore water plays an important role in understanding all rainfall-induced landslide processes, from landslide initiation to sediment discharge.
Impact of herbivory by Zerenopsis lepida (Lepidoptera: Geometridae) on the endangered Encephalartos eugene-maraisii under field conditions
Authors: Janse van Rensburg P. D. , Bezuidenhout H. , Van den Berg J. 
Published: May 2023

AbstractEncephalartos eugene-maraisii is an endangered, endemic plant in the Waterberg Mountain range of South Africa. This is the first report of herbivory by Zerenopsis lepida (Lepidoptera: Geometridae) on natural populations of E. eugene-maraisii. The impact of herbivory by folivorous arthropods on this cycad species has not been studied before. This study aimed to determine the incidence and intensity of Z. lepida herbivory on E. eugene-maraisii under field conditions. Local plant dynamics were studied by recording the plant location, sex, size and phenological stage for each plant. Damage surveys were carried out over two consecutive seasons (2020–2021 and 2021–2022). Leaf damage was assessed on 227 plants comprising 692 stems. Approximately 40% of the stems had signs of leaf herbivory by Z. lepida and 10% of the total leaf area was removed by Z. lepida larvae. Less herbivory was recorded in areas where plants synchronously produced new leaf flushes compared to areas with asynchronous leaf flushes. Greater apparency of plants led to a greater incidence of herbivory and level of damage. Repeated damage to plants may delay future leaf and cone flushing events and contribute to the threat against this cycad species.
Seasonal and Station Effects Modelling to Extreme Temperature Data in South Africa
Authors: Diriba Tadele Akeba , Debusho Legesse Kassa 
Published: May 2023

AbstractExtreme value theory has been widely applied to weather variables, and rigorous approaches have also been employed to investigate the seasonality and dependencies to extreme values of weather variables. To investigate the seasonal and station effects of daily maximum and minimum temperatures data, station and season specific effects model have been introduced in the parameters of general Pareto distribution. Then, the seasonality and station variations that are inherent in the data under consideration were assessed applying mainly the Bayesian approach. Non-informative and informative priors were used for estimation of the parameters. The seasonal and station effects parameters of the general Pareto distribution were estimated through the introduced models, allowing the sharing of information between stations and seasons. Simulation study was also carried out to investigate the precision of estimators for the GPD parameters with and without the effects, station and seasonal, to simulated data. The models employed improved precision of the station and seasonal effects parameter estimators at individual stations and in individual seasons. The study also depicted the significance of introducing seasonal and station variabilities when modelling extreme values using univariate method, which allows information to be pooled across stations and seasons. Results obtained in this study have essential scientific and practical applications. In an extreme temperature setting, designing a level without taking the station and seasonal effects into account could lead to significant under-protection. Hence, it is important to consider what is expected to be colder or warmer than usual by identifying the effects of stations and seasons in the analysis. This would benefit greatly local governments, researchers and farmers, which they can use to suggest adaptation and mitigation steps to improve resilience.
Global, Nordic, or institutional visions? An investigation into how Nordic universities are adapting to the SDGs
Authors: Stensaker Bjørn , Hermansen Hege 
Published: May 2023

Abstract
After their launch by the UN in 2015, the Sustainable Development Goals (SDGs) have been seen as landmarks for global survival. Higher education has been given a key role in the implementation of the SDGs, and the current article investigates how a sample of Nordic higher education institutions have been adapting to the SDGs. Based on the assumption that some SDGs are closely linked to traditional Nordic values such as inclusion and equality, one could expect that higher education institutions in this region would find it easy to adopt (specific parts of) the SDGs. However, although such adaptation is detectable at some institutions, many institutions seem to adapt to the SDGs in more symbolic ways. The findings are discussed in relation to the impact of globalization on Nordic higher education, along with how and to what extent globalized ideas are translated into local contexts.
A Mission Planning Framework for Fleets of Connected UAVs
Authors: Silva Margarida , Reis André , Sargento Susana 
Published: May 2023

AbstractCurrently, several platforms offer solutions for the management and control of fleets of unmanned aerial vehicles (UAVs), addressing a wide range of scenarios, each with its own particular set of objectives. Some of these solutions are mission planning platforms for broader usage, without aiming to solve a single scenario. However, these often either do not support multi-UAV collaboration or generate a static flight trajectory, which does not facilitate the coordination of a fleet of several UAVs in a mission that may need to adapt to the current environment. Through the development of a domain-specific language (DSL) - EasyMission - for UAV mission definition and control, we introduce a mission planning framework that makes it possible to describe mission plans that also enable the user to define adjustments and constraints that may have to be taken into account in real-time according to sensor readings or other events. This framework enables inexperienced users to design missions with low or moderate complexity levels, while still being a useful tool for advanced users due to its versatility in addressing multiple scenarios through a single platform. We show how the mission framework is able to easily define differentiated mission examples with distinct purposes and scenarios, and with real-time decisions and constraints.
Predicting High-Risk Gambling Based on the First Seven Days of Gambling Activity After Registration Using Account-Based Tracking Data
Authors: Auer Michael , Griffiths Mark D. 
Published: May 2023

AbstractIn recent years, several European regulators have introduced mandatory player tracking to identify potentially problematic online gambling. The present study’s aim was to investigate the possibility of predicting future high-risk gambling based on a short time window (i.e., the first seven days after the registration for an online gambling site). The authors were given access to a secondary dataset comprising 37,986 gamblers who registered at a European online gambling operator between January 1 and April 30, 2022. The study examined the association between gambling behavior during the first week after registration and high-risk gambling during the first 90 days after registration. A logistic regression model with high-risk gamblers (based on the first three months of gambling data after initial registration) as the dependent variable and age, gender, and the first week’s gambling behavior as independent variables explained 40% of the variance. Age, gender, and seven player tracking features from the first week after registration were significant. Machine learning models confirmed the high correlation between the first week of gambling and a high-risk classification during the first three months after registration. The most important features reported by a Random Forest and a Gradient Boost Machine model were the total amount of money deposited, the number of deposits, the amount of money lost, and the average number of deposits per session. The study showed that high-risk gambling during the first three months of a player’s lifetime can be predicted very early after registration. These findings suggest that gambling operators should initiate preventive measures (such as limit setting, mandatory play-breaks, personalized messaging) and monitor gambling behavior at a very early stage after a gambler’s initial registration.
The Association Between Adolescent Vaping and Subsequent Use of Other Substances and Risk Factors for Polysubstance Use
Authors: Salmon Samantha , Pappas Katerina V. , Taillieu Tamara L. , Stewart-Tufescu Ashley , Sareen Jitender , MacMillan Harriet L. , Tonmyr Lil , Brownell Marni , Nickel Nathan C. , Afifi Tracie O. 
Published: May 2023

Abstract
Objectives
Adolescent vaping has become a public health concern. The aim of this study was to examine the associations between adolescent vaping and subsequent use of other substances and risk factors for polysubstance use.

Methods
The Well-being and Experiences Study is a longitudinal, intergenerational study conducted in Manitoba, Canada. The sample for this study consisted of adolescents and emerging adults who participated in Waves 1 (N = 1,002; 2017-18; aged 14–17 years) and 2 (n = 756; 2019; aged 15–20 years). Multinomial logistic regression analysis was performed.

Results
Adolescent vaping was associated with continued use of alcohol, cannabis, and cigarettes (adjusted relative risk ratio [aRRR] range: 12.92–19.39), new onset use of cannabis (aRRR: 6.04) and cigarettes (aRRR: 3.66), and concurrent and simultaneous polysubstance use (aRRR range: 3.14–24.25). Several risk factors were identified for concurrently using three or four substances in the past year (aRRR range: 1.76–2.86) and simultaneously using alcohol, cannabis, and nicotine (aRRR range: 1.99–3.11). Among those who reported vaping nicotine at Wave 2, 33.6% of males and 24.2% of females reported doing so as a coping mechanism.

Conclusions
Adolescent vaping is a risk factor for subsequent use of other substances and polysubstance use. Efforts are needed to prevent vaping initiation and help adolescents with cessation. Strategies should include selective interventions for those with histories of childhood adversity and mental health disorder.
Chemical shift assignments of retinal guanylyl cyclase activating protein 5 (GCAP5) with a mutation (R22A) that abolishes dimerization and enhances cyclase activation
Authors: Cudia Diana , Ahoulou Effibe O. , Ames James B. 
Published: May 2023

AbstractRetinal membrane guanylyl cyclases (RetGCs) in vertebrate rod and cone photoreceptors are activated by a family of neuronal Ca2+ sensor proteins called guanylyl cyclase activating proteins (GCAP1-7). GCAP5 from zebrafish photoreceptors binds to RetGC and confers Ca2+/Fe2+-dependent regulation of RetGC enzymatic activity that promotes the recovery phase of visual phototransduction. We report NMR chemical shift assignments of GCAP5 with a R22A mutation (called GCAP5R22A) that abolishes protein dimerization and activates RetGC with 3-fold higher activity than that of wild type GCAP5 (BMRB No. 51,783).
1H, 13C, 15N backbone chemical shift assignments of the extended ARID domain in human AT-rich interactive domain protein 5a (Arid5a)
Authors: von Ehr Julian , Korn Sophie Marianne , Weiß Lena , Schlundt Andreas 
Published: May 2023

AbstractThe family of AT-rich interactive domain (ARID) containing proteins -Arids- contains 15 members that have almost exclusively been described as DNA-binding proteins. Interestingly, a decade ago the family member Arid5a was found to bind and stabilize mRNAs of immune system key players and thereby account for driving inflammatory and autoimmune diseases. How exactly binding to DNA and RNA is coordinated by the Arid5a ARID domain remains unknown, mainly due to the lack of atom-resolved information on nucleic acid-binding. This in particular applies to the protein’s ARID domain, despite the comfortable size of its core unit for NMR-based investigations. Furthermore, the core domain of ARID domains is found to be extended by functionally relevant, often flexible stretches, but whether such elongations are present and crucial for the versatile Arid5a functions is unknown. We here provide a near-complete NMR backbone resonance assignment of the Arid5a ARID domain with N- and C-terminal extensions, which serves as a basis for further studies of its nucleic acid-binding preferences and targeted inhibition by means of NMR. Our data thus significantly contribute to unravelling mechanisms of Arid5a-mediated gene regulation and diseases.
Charting Directions for—and Challenges at Being Able to Undertake—Future Research on African Urban Sexualities
Authors: Tucker Andrew 
Published: May 2023

AbstractThe aim of this article is to summarise and draw out potential synergies across the contributions that preceded it to help chart potential future areas of research interest, and to acknowledge some of the persistent challenges that can hinder future research on the topic of African urban sexualities—and specifically non-heteronormative sexualities. As the second half of this article makes clear, it is vital that various challenges are acknowledged and hopefully addressed if the topic of African urban sexualities is to reach its fuller potential within the academy. First, however, I turn to the question of synergies and potential areas of future research interest.