bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence to support publishing and peer review: A summary and review
Authors: Kousha Kayvan , Thelwall Mike 
Published: August 2023

AbstractTechnology is being developed to support the peer review processes of journals, conferences, funders, universities, and national research evaluations. This literature and software summary discusses the partial or complete automation of several publishing‐related tasks: suggesting appropriate journals for an article, providing quality control for submitted papers, finding suitable reviewers for submitted papers or grant proposals, reviewing, and review evaluation. It also discusses attempts to estimate article quality from peer review text and scores as well as from post‐publication scores but not from bibliometric data. The literature and existing examples of working technology show that automation is useful for helping to find reviewers and there is good evidence that it can sometimes help with initial quality control of submitted manuscripts. Much other software supporting publishing and editorial work exists and is being used, but without published academic evaluations of its efficacy. The value of artificial intelligence (AI) to support reviewing has not been clearly demonstrated yet, however. Finally, whilst peer review text and scores can theoretically have value for post‐publication research assessment, it is not yet widely enough available to be a practical evidence source for systematic automation.
Particle Network Self‐Assembly of Similar Size Sub‐Micron Calcium Alginate and Polystyrene Particles Atop Glass
Authors: Onuh Gideon , Bar‐On Roi , Manor Ofer 
Published: August 2023

AbstractParticle‐mediated self‐assembly, such as nanocomposites, microstructure formation in materials, and core‐shell coating of biological particles, offers precise control over the properties of biological materials for applications in drug delivery, tissue engineering, and biosensing. The assembly of similar‐sized calcium alginate (CAG) and polystyrene sub‐micron particles is studied in an aqueous sodium nitrate solution as a model for particle‐mediated self‐assembly of biological and synthetic mixed particle species. The objective is to reinforce biological matrices by incorporating synthetic particles to form hybrid particulate networks with tailored properties. By varying the ionic strength of the suspension, the authors alter the energy barriers for particle attachment to each other and to a glass substrate that result from colloidal surface forces. The particles do not show monotonic adsorption trend to glass with ionic strength. Hence, apart from DLVO theory—van der Waals and electrostatic interactions—the authors further consider solvation and bridging interactions in the analysis of the particulate adsorption‐coagulation system. CAG particles, which support lower energy barriers to attachment relative to their counterpart polystyrene particles, accumulate as dense aggregates on the glass substrate. Polystyrene particles adsorb simultaneously as detached particles. At high electrolyte concentrations, where electrostatic repulsion is largely screened, the mixture of particles covers most of the glass substrate; the CAG particles form a continuous network throughout the glass substrate with pockets of polystyrene particles. The particulate structure is correlated with the adjustable energy barriers for particle attachment in the suspension.
A Mechanistic Study on the Hydrolysis of Cyclic Ketene Acetal (CKA) and Proof of Concept of Polymerization in Water
Authors: Mothe Srinivasa Reddy , Chennamaneni Lohitha Rao , Tan Jacqueline , Lim Freda C. H. , Zhao Wenguang , Thoniyot Praveen 
Published: August 2023

AbstractThe present work systematically investigates the hydrolysis mechanism of cyclic ketene acetal (CKA) monomers in detail and explores polymerization in water under organic solvent‐free and surfactant‐free conditions. To understand the effect of CKA structure on hydrolysis, the ring size of the monomers is varied from 5–8‐membered rings systematically and hydrolysis experiments are performed. In all cases, hydrolysis yields monoacetylated diol products. Deuterium and 17O‐isotopic labeled experiments are carried out for 5‐ and 7‐membered‐(2‐methylene‐1,3‐dioxepane, MDO) CKAs to understand the reaction pathway. The experimental analysis from the reaction of CKA with water revealed that the increasing hydrophobicity from 5–8‐membered rings and the pH of the reaction medium play important roles in the order of reactivity. Density functional theory (DFT) and experimental studies demonstrated that basic reaction conditions have some control over the hydrolysis rate of CKA. Despite this progress, achieving controlled polymerization of CKA in water while suppressing hydrolysis remains challenge. Only up to 3 mol% CKA incorporation is attained in polyacrylate and polyacrylamide backbone via radical ring‐opening polymerization (rROP) of MDO and 8‐membered CKAs with 2‐hydroxyethyl acrylate (HEA) and acrylamide (AAm) in water. The results serve a proof of concept for advancing aqueous copolymerizations using CKA monomers.
Weighted norm inequalities for multilinear strongly singular Calderón–Zygmund operators on RD‐spaces
Authors: Li Wei , Wu Lian 
Published: August 2023

AbstractLet be an RD‐space, namely, a space of homogeneous type in the sense of Coifman and Weiss with the Borel measure μ satisfying the reverse doubling condition on . Based on this space, the authors define a multilinear strongly singular Calderón–Zygmund operator whose kernel does not need any size condition and has more singularities near the diagonal than that of a standard multilinear Calderón–Zygmund operator. For such an operator, we establish its boundedness on product of weighted Lebesgue spaces by means of the pointwise estimate for the sharp maximal function. In addition, the endpoint estimates of the type are also obtained. Moreover, we prove weighted boundedness results for multilinear commutators generated by multilinear strongly singular Calderón–Zygmund operators and BMO functions. These results contribute to the extension of multilinear strongly singular Calderón–Zygmund operator theory in the Euclidean case to the context of space of homogeneous type.
The acute effects of repetitive transcranial magnetic stimulation on laminar diffusion anisotropy of neocortical gray matter
Authors: Zhang Wenjing , Liu Naici , Zhao Youjin , Yao Chenyang , Yang Dan , Yang Chengmin , Sun Hui , Wei Xia , Sweeney John A. , Liang Huilou , Zhang Miaoqi , Gong Qiyong , Lui Su 
Published: August 2023

AbstractRepetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. Inhibitory and excitatory regimens have been both adopted but the exact mechanism of action remains unclear, and investigating their differential effects on laminar diffusion profiles of neocortex may add important evidence. Twenty healthy participants were randomly assigned to receive a low‐frequency/inhibitory or high‐frequency/excitatory rTMS targeting the left dorsolateral prefrontal cortex (DLPFC). With the brand‐new submillimeter diffusion tensor imaging of whole brain and specialized surface‐based laminar analysis, fractional anisotropy (FA) and mean diffusion (MD) profiles of cortical layers at different cortical depths were characterized before/after rTMS. Inhibitory and excitatory rTMS both showed impacts on diffusion metrics of somatosensory, limbic, and sensory regions, but different patterns of changes were observed—increased FA with inhibitory rTMS, whereas decreased FA with excitatory rTMS. More importantly, laminar analysis indicated laminar specificity of changes in somatosensory regions during different rTMS patterns—inhibitory rTMS affected the superficial layers contralateral to the DLPFC, while excitatory rTMS led to changes in the intermediate/deep layers bilateral to the DLPFC. These findings provide novel insights into acute neurobiological effects on diffusion profiles of rTMS that may add critical evidence relevant to different protocols of rTMS on neocortex.
Myogenically differentiated mesenchymal stem cell insulin sensitivity is associated with infant adiposity at 1 and 6 months of age
Authors: Jevtovic Filip , Zheng Donghai , Houmard Joseph A. , Kern Kara , Claiborne Alex , Lopez Christian A. , Broskey Nicholas T. , Isler Christy , DeVente Jim , Newton Edward , May Linda E. 
Published: August 2023

AbstractObjectiveIn adults, skeletal muscle insulin sensitivity (SI) and fatty acid oxidation (FAO) are linked with a predisposition to obesity. The current study aimed to determine the effects of maternal exercise on a model of infant skeletal muscle tissue (differentiated umbilical cord mesenchymal stem cells [MSCs]) SI and FAO and analyzed for associations with infant body composition.MethodsFemales <16 weeks' gestation were randomized to either 150 min/wk of moderate‐intensity aerobic, resistance, or combination exercise or a nonexercising control. At delivery, MSCs were isolated from umbilical cords and myogenically differentiated, and SI and FAO were measured using radiolabeled substrates. Infant body fat percentage (BF%) and fat‐free mass were calculated using standard equations at 1 and 6 months of age.ResultsMSCs from infants of all exercisers had significantly (p < 0.05) higher SI. MSC SI was inversely associated with infant BF% at 1 (r = −0.38, p < 0.05) and 6 (r = −0.65, p < 0.01) months of age. Infants with high SI had lower BF% at 1 (p = 0.06) and 6 (p < 0.01) months of age. MSCs in the high SI group had higher (p < 0.05) FAO.ConclusionsExposure to any type of exercise in utero improves offspring SI and could reduce adiposity in early infancy.
Influence of Different Treatments on the Structure and Conversion of Silicon Species in Rice Straw to Tetraethyl Orthosilicate (TEOS)
Authors: Sun Qianxin , Feng Shanshan , Li Guiying , Qi Yue , Hu Changwei 
Published: August 2023

AbstractThe production of tetraethyl orthosilicate (TEOS) from biomass provides a new way for TEOS production and biomass valorization. In this study, rice straw was treated using different fractionation methods, and the content, state, and reactivity of Si in the treated samples were investigated. It was found that acid treatment and ethanol extraction kept most Si in the biomass, while alkali treatment caused significant Si loss. Si was mainly present in the SiOx, Si−O−C, and Si−O−Si states in the surface of raw rice straw, cellulose and Klason lignin. The results showed that the Si−O−Si state in rice straw was beneficial for the formation of TEOS. The removal of lipids from rice straw facilitated the production of TEOS, giving the highest TEOS yield of 76.2 %. In contrast, the production of TEOS from other samples became difficult; the simultaneous conversion of the three organic components of rice straw also facilitated the production of TEOS.
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†
Authors: Balasubramanian Adithya , John Thomas , Adams David J 
Published: August 2023

AbstractWe are constantly exposed to chemicals and other agents in our environment that can influence our risk of tumorigenesis, but exactly how these factors contribute to cancer development is largely unknown. Fine particulate matter measuring ≤2.5 μm (PM2.5) from air pollution can accumulate in alveoli, contributing to inflammation and tissue damage. Despite prior correlative studies highlighting the mortality risk, there has been a historical reluctance to lower national standards for safe PM2.5 exposure. A recent publication further highlights the attributable risk of PM2.5 exposure with lung cancer – particularly in ‘never‐smokers’ with EGFR‐driven non‐small cell lung cancer. Importantly, it also elucidates a mechanistic link between PM2.5 exposure and tumorigenesis using in vivo models of EGFR non‐small cell lung cancer. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Synthesis, characterization, electrical, and magnetic properties of polyvinyl alcohol/carboxymethyl cellulose blend doped with nickel ferrites nanoparticles for magneto‐electronic devices
Authors: Al‐Sagheer L. A. M. , Rajeh A. 
Published: August 2023

AbstractSolid polymer electrolytes are an intriguing technology in terms of magneto‐opto electronic applications due to having a high dielectric constant, a small band gap, and excellent magnetic characteristics. In order to improve structural, optical, dielectric, conductivity, and magnetic characteristics, this research seeks to prepare nickel ferrite (NiFe2O4) nanoparticles and polyvinylalcohol (PVA)/carboxymethyl cellulose (CMC) films containing NiFe2O4. Nanoparticles of NiFe2O4 are prepared using the co‐precipitation method. The CMC/PVA–NiFe2O4 nanocomposites films are prepared using casting solution. To improve their structural, optical, conductivity, dielectric, and magnetic characteristics, these films electrolytes were examined using XRD, TEM, FT‐IR, UV–vis, and VSM measurements. According to the XRD analysis, the CMC/PVA blend polymer matrix demonstrates a considerable increase in amorphous nature with the NiFe2O4 nanoparticles (NPs) content, producing a highly flexible polymer backbone, increasing ionic conductivity of the CMC/PVA–NiFe2O4 nanocomposite films. The complexation of dopant cations with the CMC/PVA polymer matrix's backbone is confirmed by the FT‐IR spectroscopy. According to the UV–visible technique, the dopant NiFe2O4 concentration considerably affects the optical energy band gap, and Urbach energy of the pure CMC/PVA. At higher loading, these effects are more pronounced. At room temperature, ac conductivity, the dielectric behavior, and electrical modulus formalism were studied. The blend's highest AC conductivity is 4.77 × 103 S/cm. After increasing the loading of NiFe2O4 to 1.5 wt%, it increased to 8.07 × 104 S/cm. There has also been research on dielectric permittivity and electric modulus to further understand conductivity relaxation and charge storage qualities. The polymer nanocomposite, generally, displayed better optical, dielectric constant, conductivity, and magnetic characteristics compared to pure CMC/PVA being useable in terms of high energy storage nanoelectronics' manufacturing.Highlights
NiFe2O4 nanoparticles were prepared by using the co‐precipitation method.
Nanocomposite films of CMC/PVA–NiFe2O4 were successfully prepared by casting method.
XRD patterns confirmed the increase in the degree amorphousity for nanocomposites films compare pure blend.
From optical energy gap results for samples prepared was enhanced after addition NiFe2O4.
The dielectric and magnetic properties showed that all nanocomposites films exhibited enhanced as compared to pure CMC/PVA film.
Transcriptome analyses of leaf architecture in Sansevieria support a common genetic toolkit in the parallel evolution of unifacial leaves in monocots
Authors: Golenberg Edward M. , Popadić Aleksandar , Hao Weilong 
Published: August 2023

AbstractPlanar structures dramatically increase the surface‐area‐to‐volume ratio, which is critically important for multicellular organisms. In this study, we utilize naturally occurring phenotypic variation among three Sansivieria species (Asperagaceae) to investigate leaf margin expression patterns that are associated with mediolateral and adaxial/abaxial development. We identified differentially expressed genes (DEGs) between center and margin leaf tissues in two planar‐leaf species Sansevieria subspicata and Sansevieria trifasciata and compared these with expression patterns within the cylindrically leaved Sansevieria cylindrica. Two YABBY family genes, homologs of FILAMENTOUS FLOWER and DROOPING LEAF, are overexpressed in the center leaf tissue in the planar‐leaf species and in the tissue of the cylindrical leaves. As mesophyll structure does not indicate adaxial versus abaxial differentiation, increased leaf thickness results in more water‐storage tissue and enhances resistance to aridity. This suggests that the cylindrical‐leaf in S. cylindrica is analogous to the central leaf tissue in the planar‐leaf species. Furthermore, the congruence of the expression patterns of these YABBY genes in Sansevieria with expression patterns found in other unifacial monocot species suggests that patterns of parallel evolution may be the result of similar solutions derived from a limited developmental toolbox.
Cerebrospinal fluid proteins in idiopathic intracranial hypertension: An exploratory SWATH proteomics analysis
Authors: Pandit Awadh Kishor , Misra Shubham , Sengupta Shantanu , Chakraborty Rahul , Singh Praveen , Singh Gyaninder Pal , Phuljhele Swati , Srivastava Achal K. , Vibha Deepti , Garg Ajay , Shankar Vivek , Mohania Dheeraj , Shukla Garima , Prasad Kameshwar 
Published: August 2023

AbstractPurposeThe pathogenesis of idiopathic intracranial hypertension (IIH) is currently poorly understood. This exploratory study aimed to identify potential cerebrospinal fluid (CSF) biomarkers in IIH cases compared to controls using SWATH‐MS proteomics approach.Experimental DesignCSF samples were collected prospectively from IIH cases and control subjects which were subjected to SWATH‐MS based untargeted proteomics. Proteins with fold change > 1.5 or < 0.67 and p‐value < 0.05 were considered significantly differentially expressed. Data are available via ProteomeXchange with identifier PXD027751. Statistical analysis was conducted in R version 3.6.2.ResultsWe included CSF samples from 33 subjects, consisting of 13 IIH cases and 20 controls. A total of 262 proteins were identified in Proteinpilot search. Through SWATH analysis, we quantified 232 proteins. We observed 37 differentially expressed proteins between the two groups with 24 upregulated and 13 downregulated proteins. There were two differential proteins among overweight versus non‐overweight IIH cases. Network for 23 proteins was highly connected in the interaction analysis.Conclusions and Clinical RelevanceNeurosecretory, neuroendocrine, and inflammatory proteins were predominantly involved in causing IIH. This exploratory study served as a platform to identify 37 differentially expressed proteins in IIH and also showed significant differences between overweight and non‐overweight IIH patients.
Arginine cluster introduction on framework region in anti‐lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops
Authors: Maeta Shingo , Nakakido Makoto , Matsuura Hiroaki , Sakai Naoki , Hirata Kunio , Kuroda Daisuke , Fukunaga Atsushi , Tsumoto Kouhei 
Published: August 2023

AbstractAntibodies are used for many therapeutic and biotechnological purposes. Because the affinity of an antibody to the antigen is critical for clinical efficacy of pharmaceuticals, many affinity maturation strategies have been developed. Although we previously reported an affinity maturation strategy in which the association rate of the antibody toward its antigen is improved by introducing a cluster of arginine residues into the framework region of the antibody, the detailed molecular mechanism responsible for this improvement has been unknown. In this study, we introduced five arginine residues into an anti‐hen egg white lysozyme antibody (HyHEL10) Fab fragment to create the R5‐mutant and comprehensively characterized the interaction between antibody and antigen using thermodynamic analysis, X‐ray crystallography, and molecular dynamics (MD) simulations. Our results indicate that introduction of charged residues strongly enhanced the association rate, as previously reported, and the antibody–antigen complex structure was almost the same for the R5‐mutant and wild‐type Fabs. The MD simulations indicate that the mutation increased conformational diversity in complementarity‐determining region loops and thereby enhanced the association rate. These observations provide the molecular basis of affinity maturation by R5 mutation.
A critical inter‐subunit interaction for the transmission of the allosteric signal in the Agrobacterium tumefaciensADP‐glucose pyrophosphorylase
Authors: Patel Hiral P. , Martinez‐Ramirez Gabriela , Dobrzynski Emily , Iglesias Alberto A. , Liu Dali , Ballicora Miguel A. 
Published: August 2023

AbstractADP‐glucose pyrophosphorylase is a key regulatory enzyme involved in starch and glycogen synthesis in plants and bacteria, respectively. It has been hypothesized that inter‐subunit communications are important for the allosteric effect in this enzyme. However, no specific interactions have been identified as part of the regulatory signal. The enzyme from Agrobacterium tumefaciens is a homotetramer allosterically regulated by fructose 6‐phosphate and pyruvate. Three pairs of distinct subunit‐subunit interfaces are present. Here we focus on an interface that features two symmetrical interactions between Arg11 and Asp141 from one subunit with residues Asp141 and Arg11 of the neighbor subunit, respectively. Previously, scanning mutagenesis showed that a mutation at the Arg11 position disrupted the activation of the enzyme. Considering the distance of these residues from the allosteric and catalytic sites, we hypothesized that the interaction between Arg11 and Asp141 is critical for allosteric signaling rather than effector binding. To prove our hypothesis, we mutated those two sites (D141A, D141E, D141N, D141R, R11D, and R11K) and performed kinetic and binding analysis. Mutations that altered the charge affected the regulation the most. To prove that the interaction per se (rather than the presence of specific residues) is critical, we partially rescued the R11D protein by introducing a second mutation (R11D/D141R). This could not restore the activator effect on kcat, but it did rescue the effect on substrate affinity. Our results indicate the critical functional role of Arg11 and Asp141 to relay the allosteric signal in this subunit interface.
The influence of synoptic wind on land–sea breezes
Authors: Allouche Mohammad , Bou‐Zeid Elie , Iipponen Juho 
Published: August 2023

AbstractParticularly challenging classes of heterogeneous surfaces are ones where strong secondary circulations are generated, potentially dominating the flow dynamics. In this study, we focus on land–sea breeze (LSB) circulations resulting from surface thermal contrasts, in the presence of increasing synoptic pressure forcing. The relative importance and orientation of the thermal and synoptic forcings are measured through two dimensionless parameters: a heterogeneity Richardson number (measuring the relative strength of geostrophic wind and convection induced by buoyancy), and the angle α between the shore and geostrophic wind. Large‐eddy simulations reveal the emergence of various regimes where the dynamics are asymmetric with respect to α. Along‐shore cases result in deep LSBs similar to the scenario with no synoptic background, irrespective of the geostrophic wind strength. Across‐shore simulations exhibit a circulation cell that decreases in height with increasing synoptic forcing. However, at the highest synoptic winds simulated, the circulation cell is advected away with sea‐to‐land winds, while a shallow circulation persists for land‐to‐sea cases. Scaling analysis that relates the internal parameters Qshore (net shore volumetric flux) and qshore (net shore advected kinematic heat flux) to the external input parameters results in a succinct model of the shore fluxes that also helps explain the physical implications of the identified LSBs. Finally, the vertical profiles of the shore‐normal velocity and shore‐advected heat flux are used, with the aid of k‐means clustering, to independently classify the LSBs into four regimes (canonical, sea‐driven, land‐driven, and advected), corroborating our visual categorization.