bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer
Authors: Lin Jia‐Yi , Liu Hai‐Jun , Wu Ye , Jin Jin‐Mei , Zhou Yu‐Dong , Zhang Hong , Nagle Dale G. , Chen Hong‐Zhuan , Zhang Wei‐Dong , Luan Xin 
Published: January 2023

AbstractTargeted protein degradation (TPD) is an emerging therapeutic strategy with the potential of targeting undruggable pathogenic proteins. After the first proof‐of‐concept proteolysis‐targeting chimeric (PROTAC) molecule was reported, the TPD field has entered a new era. In addition to PROTAC, numerous novel TPD strategies have emerged to expand the degradation landscape. However, their physicochemical properties and uncontrolled off‐target side effects have limited their therapeutic efficacy, raising concerns regarding TPD delivery system. The combination of TPD and nanotechnology offers great promise in improving safety and therapeutic efficacy. This review provides an overview of novel TPD technologies, discusses their clinical applications, and highlights the trends and perspectives in TPD nanomedicine.
Ouch! Eew! Blech! A Trialogue on Porous Technologies, Places and Embodiments
Authors: Iengo Ilenia , Kotsila Panagiota , Nelson Ingrid L. 
Published: January 2023

AbstractIn this chapter, we bring political ecologies of health and the body into conversation with environmental justice and crip theory, science, technology and society studies (STS) and biopolitics. We present a trialogue that highlights three cases of health and embodiment examining the crosscutting themes of porosity and technologies as they offer us ways to insist on the right to be and signal a politics of health in FPE: (a) the lived experience of chronic pain as a catalyst for learning about environmental injustice in Naples, southern Italy, and the epistemic activism of crip communities producing counter-knowledge and mutual aid; (b) the spread of malaria among immigrant farmworkers in southern Greece as invisibilised intersectional and embodied injustice; and (c) embracing pharmaceuticals and vlogs with ambivalence while living with the temporary condition, hyperemesis gravidarum (HG) in the northeastern United States. We bring to the fore questions around bodies, harm, care and power, as those were brought about by our own situatedness in, and response-ability towards, embodied experiences of chronic pain, infection and nausea.
Meanings and Practices of Care in Feminist Political Ecology: An Intergenerational Conversation with Khayaat Fakier and Wendy Harcourt
Authors: Gómez Marlene , Voss Anna Katharina , Farrelly Eoin 
Published: January 2023

AbstractIn this chapter, the authors reflect on meanings of care through a conversation with Khayaat Fakier and Wendy Harcourt recorded in March 2022. The cross generational conversation weaves around the issue of care in relation to ethics, intersectional justice, feminism and environmental activism. We ask Khayaat and Wendy to share their perspectives on care, reflecting on the feminist roots of their activism, teaching and research.
Caring Communities for Radical Change: What Can Feminist Political Ecology Bring to Degrowth?
Authors: Barca Stefania , Di Chiro Giovanna , Harcourt Wendy , Iengo Ilenia , Kotsila Panagiota , Kulkarni Seema , Leonardelli Irene , Sato Chizu 
Published: January 2023

AbstractIn this chapter, we share the insights of feminist political ecology (FPE) for degrowth, building from the debates on “caring communities for radical change” at the 8th International Degrowth Conference in August 2021. We discuss how FPE links to the principles of degrowth as an academic and activist movement and why it is necessary to take feminist political ecology perspectives on care and caring communities in resisting, questioning, and counteracting the structural racial, gender, and wider social inequalities that uphold and are perpetuated by growth-dependent economic systems. As we critically reflect on the experiences of paid versus unpaid, collectivised versus feminised care work, we argue that care is crucial to social and ecological reproduction in order to build just, sustainable and convivial societies.
Evidenzbasiertes Feldhasenmanagement
Authors: Hackländer Klaus 
Published: January 2023

ZusammenfassungFeldhasen sind auf reich strukturierte Offenlandflächen angewiesen, die ganzjährige Deckung und Äsung bieten. In derartigen Lebensräumen wird die Zuwachsrate der Population durch negative Effekte der Prädation, der ungünstigen Witterung oder von Krankheiten weniger stark beeinflusst. Zur Erhöhung der Feldhasendichte ist daher vor allem die Erhaltung bzw. Verbesserung des Lebensraums durch Anlegen von Brachen, Blühstreifen, Hecken und Feldrainen anzustreben. Prädatorenbejagung erhöht die Junghasenüberlebensrate zusätzlich, ist aber ohne begleitende Lebensraumverbesserungsmaßnahmen nur von kurzem Erfolg gekrönt. Nicht zuletzt sollte eine mögliche Bejagung der Feldhasen den Prinzipien der nachhaltigen Jagd folgen, die sich insbesondere am Zuwachs des Feldhasenbestandes orientiert. Das Monitoring der Feldhasenpopulation und der diese beeinflussenden Faktoren stellt die Grundlage für ein adaptives Management dar.AbstractEuropean hares depend on richly structured open areas that provide year-round cover and food. In such habitats, the rate of population increase is less affected by negative effects of predation, adverse weather or diseases. Therefore, to increase the density of European hares, the main goal is to maintain or improve the habitat by creating set-asides, flower strips, hedges and field margins. Predator hunting additionally increases the survival rate of young hares, but without accompanying habitat improvement measures it is only crowned with short success. Last but not least, possible hunting of European hares should follow the principles of sustainable hunting, which is especially based on the recruitment of the hare population. Monitoring of European hare population and the factors affecting it provides the basis for adaptive management.
Stability of the cascading gauge theory de Sitter DFPs
Authors: Buchel Alex 
Published: January 2023

Abstract
We study stability of the Dynamical Fixed Points (DFPs) of the cascading gauge theory at strong coupling in de Sitter space-time. We compute the spectra of the perturbative fluctuations and identify stable/unstable DFPs, characterized by the ratio of the strong coupling scale Λ of the gauge theory and the Hubble constant H of the background space-time. We discover a new phenomenon in the spectrum of gravitational fluctuations of a non-conformal holographic model: distinct branches of the fluctuations for H ≫ Λ coalesce for sufficiently low $$ \frac{H}{\Lambda} $$

H
Λ

, leading to the removal of some excited modes from the spectrum. We establish that, at least in a dual supergravity approximation, the cascading gauge theory does not have a stable DFP for some H ~ Λ. Initial states of the theory for H ≫ Λ evolve to a stable DFP with unbroken chiral symmetry; while for H ≪ Λ the states evolve to a de Sitter vacuum with spontaneously broken chiral symmetry.
Establishment and initial implementation of the Australasian Pelvic Floor Procedure Registry
Authors: Jayasinghe Randi T. , Ruseckaite Rasa , Dean Joanne , Kartik Aruna , Wickremasinghe Anagi C. , Daly Oliver , O’Connell Helen E. , Craig Amanda , Duggan Anne , Vasiliadis Dora , Karantanis Emmanuel , Gallagher Elizabeth , Holme Gwili , Keck James , Williams Jarrod , King Jennifer , Yin Jessica , Short John , Sketcher-Baker Kirstine , Brennan Pip , Rayner Sally , Ahern Susannah 
Published: January 2023

AbstractIntroduction and hypothesisStress urinary incontinence (SUI) and pelvic organ prolapse (POP) are common pelvic floor disorders (PFDs). Owing to significant adverse events associated with mesh-related pelvic floor procedures (PFPs) in a proportion of the surgically treated population, and deficits in collection and reporting of these events, the Australian Government identified an urgent need for a tracking mechanism to improve safety and quality of care. The Australasian Pelvic Floor Procedure Registry (APFPR) was recently established following the 2018 Senate Committee Inquiry with the aim of tracking outcomes of PFP involving the use of devices and/or prostheses, with the objective of improving the health outcomes of women who undergo these procedures. This paper will describe the APFPR’s aims, development, implementation and possible challenges on the way to its establishment.MethodsThe APFPR has been developed and implemented in accordance with the national operating principles of clinical quality registries (CQRs). The minimum datasets (MDS) for the registry’s database have been developed using a modified Delphi process, and data are primarily being collected from participating surgeons. Patient recruitment is based on an opt-out approach or a waiver of consent. Patient-reported outcome measures (PROMs) providing additional health and outcome information will be obtained from participating women to support safety monitoring of mesh-related adverse events.ResultsCurrently in the Australasian Pelvic Floor Procedure Registry (APFPR) there are 32 sites from various jurisdictions across Australia, that have obtained relevant ethics and governance approvals to start patient recruitment and data collection as of January 2023. Additionally, there are two sites that are awaiting governance review and five sites that are having documentation compiled for submission. Seventeen sites have commenced patient registration and have entered data into the database. Thus far, we have 308 patients registered in the APFPR database. The registry also published its first status report and a consumer-friendly public report in 2022.ConclusionsThe registry will act as a systematic tracking mechanism by collecting outcomes on PFP, especially those involving devices and/or prostheses to improve safety and quality of care.
On the dynamics of vortices in viscous 2D flows
Authors: Ceci Stefano , Seis Christian 
Published: January 2023

AbstractWe study the 2D Navier–Stokes solution starting from an initial vorticity mildly concentrated near N distinct points in the plane. We prove quantitative estimates on the propagation of concentration near a system of interacting point vortices introduced by Helmholtz and Kirchhoff. Our work extends the previous results in the literature in three ways: The initial vorticity is concentrated in a weak (Wasserstein) sense, it is merely $$L^p$$

L
p

integrable for some $$p>2$$

p
>
2

, and the estimates we derive are uniform with respect to the viscosity.
Buzzword ISOBUS
Authors: Brodie Samuel , Oksanen Timo , Auernhammer Hermann 
Published: January 2023

AbstractFarmers will often have a single tractor which they use for many different types of farmwork. A tractor alone does not do any work, it is essentially always paired with, powering, and/or moving something else, an implement mounted on its front or rear. It is particularly common in Europe, where there are many small regional manufacturers, that a farm contains tractors and implements from many different companies. The basic purpose of ISOBUS is to enable electronic communication between the tractor and the implement(s) attached to it. The two main aspects are that it must be possible to connect devices from different manufacturers, and that it must be a plug-and-play system that works without requiring any configuration by the end user (the farmer).
Decellularized cryopreserved human pericardium: a validation study towards tissue bank practice
Authors: Montagner Giulia , Barbazza Antonia , Lugas Andrea Tancredi , Terzini Mara , Serino Gianpaolo , Bignardi Cristina , Cacciatore Matilde , Vida Vladimiro L. , Padalino Massimo A. , Trojan Diletta 
Published: January 2023

AbstractPericardial patches are currently used as reconstructive material in cardiac surgery for surgical treatment of cardiac septal defects. Autologous pericardial patches, either treated with glutaraldehyde or not, can be used as an alternative to synthetic materials or xenograft in congenital septal defects repair. The availability of an allogenic decellularized pericardium could reduce complication during and after surgery and could be a valid alternative. Decellularization of allogenic tissues aims at reducing the immunogenic reaction that might trigger inflammation and tissue calcification over time. The ideal graft for congenital heart disease repair should be biocompatible, mechanically resistant, non-immunogenic, and should have the ability to growth with the patients. The aim of the present study is the evaluation of the efficacy of a new decellularization protocol of homologous pericardium, even after cryopreservation. The technique has proven to be suitable as a tissue bank procedure and highly successful in the removal of cells and nucleic acids content, but also in the preservation of collagen and biomechanical properties of the human pericardium.
The Role of Space-Based Observations for Groundwater Resource Monitoring over Africa
Authors: Springer Anne , Lopez Teodolina , Owor Michael , Frappart Frédéric , Stieglitz Thomas 
Published: January 2023

Abstract
Africa is particularly vulnerable to climate change impacts, which threatens food security, ecosystem protection and restoration initiatives, and fresh water resources availability and quality. Groundwater largely contributes to the mitigation of climate change effects by offering short- to long-term transient water storage. However, groundwater storage remains extremely difficult to monitor. In this paper, we review the strengths and weaknesses of satellite remote sensing techniques for addressing groundwater quantity issues with a focus on GRACE space gravimetry, as well as concepts to combine satellite observations with numerical models and ground observations. One particular focus is the quantification of changes in groundwater resources in the different climatic regions of Africa and the discussion of possible climatic and anthropogenic drivers. We include a thorough literature review on studies that use satellite observations for groundwater research in Africa. Finally, we identify gaps in research and possible future directions for employing satellite remote sensing to groundwater monitoring and management on the African continent.

Article Highlights

Overview on the distribution and characteristics of African groundwater resources including future projections

Combination of satellite and in situ observations with numerical models allows us to obtain a synoptic view of groundwater-related processes

Summary of current concepts and achievements of satellite remote sensing-based groundwater monitoring and decision making over Africa
Effect of polymeric dye network bonding on fluorescence thermometry for optical fiber temperature sensor
Authors: Mahmoud Taghreed M. , Negm Nabel A. , Abou Kana Maram T. H. , Fattah Gamal Abdel 
Published: January 2023

AbstractFluorescein and two of its derivatives (allyl Fluorescein and diallyl Fluorescein) are solidified in glycidyl methacrylate (GMA) polymer matrix for the development of fluorescence-based fiber optically temperature sensor. These two Fluorescein derivatives were investigated in order to study the influence of degree of covalent bonds to GMA polymer backbone on Fluorescein dye sensitivity for temperature changes. The dye-polymer discs have been investigated separately in order to determine their sensitivities in the temperature ranges from 10 to 300 K and from 297 to 370 K. The dye-polymer discs are excited by Argon ion laser (488 nm, 50 mW) and the fluorescence intensity is measured using lock-in technique. Below room-temperature Fluorescein dye in (GMA) polymer shows very weak sensitivity toward temperature changes in the range from 10 up to 297 K. The fluorescence intensity peaks of allyl Fluorescein dye in (GMA) polymer exhibit tendency for decreasing slightly, while the dye is warmed up from 40 to 245 K. Also, the fluorescence intensity peaks of diallyl Fluorescein dye in (GMA) are reported in the temperature range from 49 to 300 K. The intensity peak values decrease gradually, whereas at the temperature 171 and 229 K the peaks show hazard change. Above room temperature, the fluorescence intensity peaks decrease with increasing temperature in the temperature range from 302 to 370 K.
Environmental pollution in North-Eastern Italy and its influence on chronic obstructive pulmonary disease: time series modelling and analysis using visibility graphs
Authors: Aranburu-Imatz Alejandra , Jiménez-Hornero Jorge E. , Morales-Cané Ignacio , López-Soto Pablo Jesús 
Published: January 2023

Abstract
The impact on human health from environmental pollution is receiving increasing attention. In the case of respiratory diseases such as chronic obstructive pulmonary disease (COPD), the relationship is now well documented. However, few studies have been carried out in areas with low population density and low industrial production, such as the province of Belluno (North-Eastern Italy). The aim of the study was to analyze the effect of exposure to certain pollutants on the temporal dynamics of hospital admissions for COPD in the province of Belluno. Daily air pollution concentration, humidity, precipitations, and temperature were collected from the air monitoring stations in Belluno. Generalized additive mixed models (GAMM) and visibility graphs were used to determine the effects of the short-term exposure to environmental agents on hospital admissions associated to COPD. In the case of the city of Belluno, the GAMM showed that hospital admissions were associated with NO2, PM10, date, and temperature, while for the city of Feltre, GAMM produced no associated variables. Several visibility graph indices (average edge overlap and interlayer mutual information) showed a significant overlap between environmental agents and hospital admission for both cities. Our study has shown that visibility graphs can be useful in establishing associations between environmental agents and COPD hospitalization in sparsely populated areas.
The Microbiome’s Influence on Head and Neck Cancers
Authors: Dorobisz Karolina , Dorobisz Tadeusz , Zatoński Tomasz 
Published: January 2023

Abstract
Purpose of Review
Head and neck tumors (HNC) rank sixth among cancers worldwide. Due to their late diagnosis and poor prognosis, they are a clinical challenge. However, recent years have seen a dynamic development of science on the microbiome. The aim of the study is to discuss the role of the microbiome in HNC, the impact of the microbiome on oncogenesis, the course of the disease, as well as on treatment, and its toxicity.

Recent Findings
The microbiome’s influence on oncogenesis, the course of the disease, and the effectiveness of oncological treatment have been confirmed in cancers of the colon, pancreas, lungs, and prostate. There is no solid literature on HNC. Many studies indicate disruption of the oral microbiome and periodontal disease as potential cancer risk factors. Disruption of the microbiome increases radiotherapy’s toxicity, intensifying radiation reactions.

Summary
The microbiome plays an important role in cancer. It is a new target in research into new therapies. It may also be a prognostic marker of cancer development. Changes in the composition of the microbiome modulate the effectiveness of oncological treatment. More research is needed on the microbiome and its effects on HNC.
The Effects of Mindfulness-Based Interventions on Telomere Length and Telomerase Activity: A Systematic Review and Meta-Analysis
Authors: Bossert Lukas , Arzberger Karla , Dorok Fabian , Kern Julia , Stickler Charlotte , Wunderlich Maximilian , Tran Ulrich S. 
Published: January 2023

Abstract

Objectives
Previous meta-analyses suggested that mindfulness-based interventions (MBIs) may have beneficial effects on telomere length (TL) and telomerase activity (TA), two biological markers of cellular aging and cell stress. The present review aimed to provide the most comprehensive synthesis of the available evidence to date and tested a number of important effect moderators.

Method
Twenty-five studies (18 RCTs, 1 RCT and cohort study, 6 non-randomized studies) with 2099 participants in total were obtained with a systematic literature search, 10 studies had not been included in any previous meta-analysis. Effect sizes were aggregated with random-effects models, the risk of bias was evaluated with standardized checklists, and the most influential moderators were identified with a machine-learning approach.

Results
On average, MBIs had small-to-medium effects on TL (g = 0.23, 95% CI = [0.07, 0.39], p = 0.006) and TA (g = 0.37 [0.01, 0.73], p = 0.046), which, however, were driven by retrospective case–control studies with experienced meditators (TL) and by studies without control interventions and studies from Asia (TA). Most studies had an unclear risk of bias and low analytic power, and there was an indication of publication bias among the TL studies.

Conclusions
TL may not be a useful outcome to assess the efficacy of common MBIs. Effects on TA were smaller than previously assumed and may not be specific for MBIs; TA likely is increased by other active interventions as well. More high-quality and high-powered studies, which also apply open-science practices, are needed to move the field forward.
Sustainable development goals for industry, innovation, and infrastructure: demolition waste incorporated with nanoplastic waste enhanced the physicomechanical properties of white cement paste composites
Authors: Abdelzaher M. A. 
Published: January 2023

AbstractThe COVID-19 pandemic significantly impacts the increase in plastic waste from food packaging, masks, gloves, and personal protective equipment (PPE), resulting in an environmental disaster, if collected, processed, transported, or disposed inappropriately. Plastic waste has a very long deterioration time in the environment (soil and water), cheap, and plentiful. Additionally, construction waste disposal is a process that transfers debris to a state that does lead to any sustainable or environmental problems. The core objective of this current research work is to provide safety and efficacy by partial substitution of both ultrafine demolition waste (UDW), incorporated with nanoplastic waste (NPW), for eco-white cement (E-WC) composition. E-WC is designed by partially substituted WC with UDW (1.0, 5.0, 10.0, 15.0, and 20.0 wt.%); incorporated with NPW (1.0 and 3.0 wt.%); to adequately protect people and the environment over long periods. The context examines the high performance, physicomechanical properties and high durability of blends as presences of silica in UDW proposed a hydraulic filler material, plus; high surface area of NPW. The microstructure and workability are characterized by X-Ray Fluorescence (XRF), Scanning Electron Microscope (SEM), and Transmission Electron Microscope (TEM) measurements. The record results show greatly enhanced in the mechanical strength due to the combination of NPW and UDW (active silica). With the presence of NPW and UDW in WC matrix, the highest level of crystallization formed consequently a decrease in whiteness reflection (Ry) and total porosity. In summary, WC blend with NPW and UDW reflects better workability and energy saving qualities, which are economical and environmentally beneficial and may result in decreased construction budget and improve a long-term raw material sustainability.
Curvature locus of a 3-manifold having a normal bundle with some flat direction
Authors: Monterde J. 
Published: January 2023

AbstractA well known result states that the curvature of the normal bundle of ann-manifold immersed in the Euclidean space,$${\mathbb {R}}^{n+k}$$Rn+k, vanishes if and only if the curvature locus at any point is a convex polytope. In the case of 3-manifolds, the curvature locus is, generically, a triangle. In this paper we determine, among all the possible curvature locii of 3-manifolds immersed in$${\mathbb {R}}^{3+3}$$R3+3, which ones can be projected on a triangle and we relate them with the curvature of the normal bundle.