bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
Authors: Zukowska Dominika , Gedaj Aleksandra , Porebska Natalia , Pozniak Marta , Krzyscik Mateusz , Czyrek Aleksandra , Krowarsch Daniel , Zakrzewska Malgorzata , Otlewski Jacek , Opalinski Lukasz 
Published: April 2023

AbstractFGF/FGFR signaling is critical for the development and homeostasis of the human body and imbalanced FGF/FGFR contributes to the progression of severe diseases, including cancers. FGFRs are N-glycosylated, but the role of these modifications is largely unknown. Galectins are extracellular carbohydrate-binding proteins implicated in a plethora of processes in heathy and malignant cells. Here, we identified a precise set of galectins (galectin-1, -3, -7, and -8) that directly interact with N-glycans of FGFRs. We demonstrated that galectins bind N-glycan chains of the membrane-proximal D3 domain of FGFR1 and trigger differential clustering of FGFR1, resulting in activation of the receptor and initiation of downstream signaling cascades. Using engineered galectins with controlled valency, we provide evidence that N-glycosylation-dependent clustering of FGFR1 constitutes a mechanism for FGFR1 stimulation by galectins. We revealed that the consequences of galectin/FGFR signaling for cell physiology are markedly different from the effects induced by canonical FGF/FGFR units, with galectin/FGFR signaling affecting cell viability and metabolic activity. Furthermore, we showed that galectins are capable of activating an FGFR pool inaccessible for FGF1, enhancing the amplitude of transduced signals. Summarizing, our data identify a novel mechanism of FGFR activation, in which the information stored in the N-glycans of FGFRs provides previously unanticipated information about FGFRs’ spatial distribution, which is differentially deciphered by distinct multivalent galectins, affecting signal transmission and cell fate.
The regulation of artificial intelligence
Authors: Finocchiaro Giusella 
Published: April 2023

AbstractBefore embarking on a discussion of the regulation of artificial intelligence (AI), it is first necessary to define the subject matter regulated. Defining artificial intelligence is a difficult endeavour, and many definitions have been proposed over the years. Although more than 70 years have passed since it was adopted, the most convincing definition is still nonetheless that proposed by Turing; in any case, it is important to be mindful of the risk of anthropomorphising artificial intelligence, which may arise in particular from its very definition. Once we have established the subject matter regulated, we must ask ourselves whether lawmakers should pursue an approach that seeks to regulate artificial intelligence as a whole, or whether by contrast they should regulate applications of artificial intelligence in specific sectors or individual areas. The proposal for a regulation on artificial intelligence published on 21 April 2021 implements the former approach whilst also pursuing geopolitical goals. After providing an initial overview of the notion of artificial intelligence, this article investigates the geopolitical context to the proposal for a regulation, and then goes on to illustrate the regulatory model embraced by the proposal as well as related critical aspects.
Effect of Vadasz term on the onset of convection in a Darcy–Brinkman anisotropic rotating porous medium in LTNE
Authors: Capone Florinda , Gianfrani Jacopo A. 
Published: April 2023

AbstractIn the present paper, the effect of the Vadasz inertia term on the onset of convective motions for a Darcy–Brinkman model is investigated. It is proved that this term leads to the possibility for oscillatory convection to occur. Hence, convection can occur via either oscillatory or steady motions. It is proved analytically that the onset of steady convection is not affected by the Vadasz term, while oscillatory convection is favoured by it. Moreover, conditions to rule out the occurrence of oscillatory convection are determined numerically. The influence of rotation, interaction coefficient and mechanical and thermal anisotropies on the onset of instability is investigated, both analytically and numerically.
Patellofemoral arthroplasty with onlay prosthesis leads to higher rates of osteoarthritis progression than inlay design implants: a systematic review
Authors: Sava Manuel-Paul , Neopoulos Georgios , Leica Alexandra , Hirschmann Michael T. 
Published: April 2023

Abstract
Purpose
The aim of this study was to report the clinical and functional outcomes, complication rates, implant survivorship and the progression of tibiofemoral osteoarthritis (OA), after new inlay or onlay patellofemoral arthroplasty (PFA), for isolated patellofemoral OA. Comparison of different implant types and models, where it was possible, also represented one of the objectives.

Methods
A systematic literature search following PRISMA guidelines was conducted on PubMed, Scopus, Embase and Cochrane databases, to identify possible relevant studies, published from the inception of these databases until 11.11.2022. Randomized control trials (RCTs), case series, case control studies and cohort studies, written in English or German, and published in peer-reviewed journals after 2010, were included. Not original studies, case reports, simulation studies, systematic reviews, or studies that included patients who underwent TKA or unicompartmental arthroplasty (UKA) of the medial or lateral compartment of the knee, were excluded. Additionally, only articles that assessed functional and/or clinical outcomes, patient-reported outcomes (PROMs), radiographic progression of OA, complication rates, implant survival rates, pain, as well as conversion to TKA rates in patients treated with PFA, using inlay or onlay trochlea designs, were included. For quality assessment, the Methodological Index for Non-Randomized Studies (MINORS) for non-comparative and comparative clinical intervention studies was used.

Results
The literature search identified 404 articles. 29 of them met all the inclusion criteria following the selection process. Median MINORS for non-comparative studies value was 12.5 (range 11–14), and for comparative studies 20.1 (range 17–24). In terms of clinical and functional outcomes, no difference between onlay and inlay PFA has been described. Both designs yielded satisfactory results at short, medium and long-term follow-ups. Both designs improved pain postoperatively and no difference between them in terms of postoperative VAS has been noted, although the onlay groups presented a higher preoperative VAS. When comparing the inlay to onlay trochlea designs, the inlay group displayed a lower progression of OA rate.

Conclusion
There is no difference in functional or clinical outcomes after PFA between the new inlay and the onlay designs, with both presenting an improvement in most of the scores that were used. A higher rate of OA progression was observed in the onlay design group.

Level of evidence
III.
Study the correlation between the instrumental and sensory evaluation of 3D-printed protein-fortified potato puree
Authors: Mirazimi Farnaz , Saldo Jordi , Sepulcre Francesc , Pujolà Montserrat 
Published: April 2023

AbstractThe creation of 3D printed food with programmed texture has the ambition of getting personalized properties through novel texture perceptions with many different ingredients and is helping the swallowing or mastication problems of vulnerable people. This study is done to determine the correlation between the instrumental and sensory evaluation of 3D-printed protein-fortified puree potatoes. At the moment there are not many studies about this correlation, and this information can be very helpful for food texture development. For people with swallowing difficulties, it is critical to have access to safe food with the desired texture. Therefore, understanding the correlation between texture-modified food will aid in the formulation of safe foods with desired sensory properties. Instrumental measurements of fortified puree were performed by a texture analyzer and the attributes obtained were firmness, consistency, cohesiveness, and index of viscosity. Quantitative descriptive analysis with eight trained panelists was employed to characterize the texture of the the3D-printed protein-fortified puree based on six sensory attributes: firmness, thickness, smoothness, rate of breakdown, adhesive, and difficulty swallowing. Three proteins (soy, cricket, and egg albumin with two different concentrations of 3 and 5%) were evaluated against puree potato without any protein as a control. The correlation results obtained from texture analysis and sensory evaluation were statistically significant (P < 0.05) which can be used to understand the impact of ingredients on textured modified puree to predict the sensory attributes which need a lot of time for training panelists.
Deep branch of the radial nerve: effect of pronation/supination on longitudinal nerve alignment
Authors: Mohana-Borges Aurea V.R. , Souza Sergio A. L. , Mohana-Borges Ronaldo , Statum Sheronda , Chung Christine B. 
Published: April 2023

Abstract
Objective
To evaluate the effect of maximal pronation and supination of the forearm on the alignment and anatomic relationship of the deep branch of the radial nerve (DBRN) at the superior arcade of the supinator muscle (SASM) by using high-resolution ultrasound (HRUS).

Materials and methods
In this cross-sectional study, HRUS in the long axis of the DBRN was performed in asymptomatic participants enrolled from March to August 2021. DBRN alignment was evaluated by measuring angles of the nerve in maximal pronation and maximal supination of the forearm independently by two musculoskeletal radiologists. Forearm range of motion and biometric measurements were recorded. Student t, Shapiro–Wilk, Pearson correlation, reliability analyses, and Kruskal–Wallis test were used.

Results
The study population included 110 nerves from 55 asymptomatic participants (median age, 37.0 years; age range, 16–63 years; 29 [52.7%] women). There was a statistically significant difference between the DBRN angle in maximal supination and maximal pronation (Reader 1: 95% CI: 5.74, 8.21, p < 0.001, and Reader 2: 95% CI: 5.82, 8.37, p < 0.001). The mean difference between the angles in maximal supination and maximal pronation was approximately 7° for both readers. ICC was very good for intraobserver agreement (Reader1: r ≥ 0.92, p < 0.001; Reader 2: r ≥ 0.93, p < 0.001), as well as for interobserver agreement (phase 1: r ≥ 0.87, p < 0.001; phase 2: r ≥ 0.90, p < 0.001).

Conclusion
The extremes of the rotational movement of the forearm affect the longitudinal morphology and anatomic relationships of the DBRN, primarily demonstrating the convergence of the nerve towards the SASM in maximal pronation and divergence in maximal supination.
Chronic stage magnetic resonance imaging findings in patients with shoulder injury related to vaccine administration (SIRVA)
Authors: Donners Ricardo , Gehweiler Julian , Kovacs Balazs , Breit Hanns-Christian , Daikeler Thomas , Harder Dorothee , Berger Christoph T. 
Published: April 2023

Abstract
Purpose
Identify chronic shoulder MRI findings in patients with known shoulder injury related to vaccine administration (SIRVA).

Materials and methods
Two fellowship-trained musculoskeletal radiologists retrospectively reviewed the MRI of nine patients with clinically established SIRVA. MRI was performed at least 4 weeks after vaccination and included intravenous contrast-enhanced sequences. MRI was reviewed for the presence of erosions, tendonitis, capsulitis, synovitis, bone marrow oedema, joint effusion, bursitis, cartilage defects, rotator cuff lesions, and lymphadenopathy. The number and location of focal lesions were recorded.

Results
Erosions of the greater tuberosity were present in 8/9 (89%), tendonitis of the infraspinatus muscle tendon in 7/9 (78%), capsulitis, synovitis, and bone marrow oedema in 5/9 (56%) cases, respectively. Effusion was found in three, and subdeltoid bursitis, rotator cuff lesions as well as cartilage defects in one patient, respectively. None of our included subjects showed axillary lymphadenopathy.

Conclusion
In this case series, greater humeral tuberosity erosions, infraspinatus muscle tendonitis, capsulitis, synovitis, and bone marrow oedema were common MRI findings in chronic SIRVA.
The effect of lifting load on the kinematic characteristics of lumbar spinous process in vivo
Authors: Chen Huanxiong , Zhong Zhenhao , Wen Wangqiang , Xu Haoxiang , Li Guojun , Su Tian , Zhang Zepei , Miao Jun 
Published: April 2023

Abstract
Background
There are limited data on the in vivo natural kinematics of the lumbar spinous process. This paper intends to explore the effect of lifting load on the in vivo movement mode of the lumbar spinous process and its biomechanical changes.

Methods
Ten asymptomatic subjects between the ages of 25 and 39 underwent CT scans of the lumbar spine in the supine position, and 3D models of L3-L5 were constructed. Using a Dual Fluoroscopy Imaging System (DFIS), instantaneous orthogonal fluoroscopic images of each subject's flexion–extension, left–right bending, and left–right rotational movements were taken under different loads (0 kg, 5 kg, 10 kg). The supine CT model was matched, using computer software, to the bony contours of the images from the two orthogonal views, so that the instantaneous 3D vertebral position at each location could be quantified. A Cartesian coordinate system was ultimately constructed at the tip of the spinous process to obtain the 6DOF kinematic data of the spinous process.

Results
In different postural movements of the trunk, there was no significant difference in the rotation angle and translation range of the lumbar spinous process under different loads (P > 0.05). In flexion to extension motion, spinous processes mainly rotate < 4° along the medial and lateral axes and translate < 4 mm along the craniocaudal direction. In the left–right bending motion, spinous processes mainly rotate < 5° along the anterior and posterior axes, and the translation is mainly coupling < 2 mm. In the rotational motion, the spinous process is mainly coupled motion, the rotation range is less than 3°, and the translation range is less than 2 mm. The distance between spinous processes measured in the supine position was 6.66 ± 2.29 mm at L3/4 and 5.08 ± 1.57 mm at L4/5.

Conclusion
The in vivo kinematics of the lumbar spinous process will not change significantly with increasing low load. In complex motion, the spinous process is dominated by coupling motion.
Anti-biofilm Activity of Povidone-Iodine and Polyhexamethylene Biguanide: Evidence from In Vitro Tests
Authors: Gryson Luc , Meaume Sylvie , Feldkaemper Ina , Favalli Filippo 
Published: April 2023

AbstractBiofilm in chronic wounds is associated with delayed healing and ineffective local treatment. The purpose of this study was to investigate the in vitro anti-biofilm activity of two commonly used antimicrobials, povidone-iodine (PVP-I) and polyhexamethylene biguanide (PHMB). The rate of anti-biofilm activity of PVP-I, PHMB, and phosphate-buffered saline (negative control) was assessed on monomicrobial biofilms of varying maturity and composition. Antimicrobial efficacy was determined by counting colony-forming units (CFU). Live/dead cell staining and time-lapse confocal microscopy were also performed. Both PVP-I and PHMB demonstrated robust in vitro anti-biofilm activity against all tested biofilms; however, PVP-I had a more rapid action versus PHMB against methicillin-resistant Staphylococcus aureus (MRSA) biofilms, as determined by both CFU counts and microscopy. PVP-I completely eradicated Pseudomonas aeruginosa biofilms of 3- and 5-day maturity (in ≤0.5 h) and 7-day maturity (in ≤3 h), while PHMB only partially depleted cell density, with no complete biofilm eradication even after 24 h. In conclusion, PVP-I had a similar in vitro anti-biofilm activity to PHMB against biofilms of varying microbial compositions and maturity, and in some cases demonstrated more potent and rapid activity versus PHMB. PVP-I may be particularly effective in treating MRSA biofilms. However, further high-quality clinical research on the efficacy of antimicrobials is required.
Interferometric laser imaging for respiratory droplets sizing
Authors: Grandoni Livia , Méès Loïc , Grosjean Nathalie , Leuzzi Giovanni , Monti Paolo , Pelliccioni Armando , Salizzoni Pietro 
Published: April 2023

AbstractDue to its importance in airborne disease transmission, especially because of the COVID-19 pandemic, much attention has recently been devoted by the scientific community to the analysis of dispersion of particle-laden air clouds ejected by humans during different respiratory activities. In spite of that, a lack of knowledge is still present particularly with regard to the velocity of the emitted particles, which could differ considerably from that of the air phase. The velocity of the particles is also expected to vary with their size. In this work, simultaneous measurements of size and velocity of particles emitted by humans while speaking have been performed by means of Interferometric Laser Imaging Droplet Sizing (ILIDS). This technique allowed us to detect emitted particles with size down to 2 µm as well as to quantify all three components of the velocity vector and the particle concentration. The outcomes of this work may be used as boundary conditions for numerical simulations of infected respiratory cloud transmission.
Graphical abstract
Pitfalls in the diagnostics of shoulder dystocia: an analysis based on the scrutiny of 2274 deliveries
Authors: Heinonen Karin , Saisto Terhi , Gissler Mika , Kaijomaa Marja , Sarvilinna Nanna 
Published: April 2023

Abstract
Purpose
Shoulder dystocia is an obstetric emergency with severe complications. Our objective was to evaluate the major pitfalls in the diagnostics of shoulder dystocia, diagnostic descriptions documented in medical records, use of obstetric maneuvers, and their correlations to Erb’s and Klumpke’s palsy and the use of ICD-10 code 066.0.

Methods
A retrospective, register-based case–control study included all deliveries (n = 181 352) in Hospital District of Helsinki and Uusimaa (HUS) area in 2006–2015. Potential shoulder dystocia cases (n = 1708) were identified from the Finnish Medical Birth Register and the Hospital Discharge Register using ICD-10 codes O66.0, P13.4, P14.0, and P14.1. After thorough assessment of all medical records, 537 shoulder dystocia cases were confirmed. Control group consisted of 566 women without any of these ICD-10 codes.

Results
The pitfalls in the diagnostic included suboptimal following of guidelines for making the diagnosis of shoulder dystocia, subjective interpretation of diagnostic criteria, and inexact or inadequate documentation in medical records. The diagnostic descriptions in medical record were highly inconsistent. The use of obstetric maneuvers was suboptimal among shoulder dystocia cases (57.5%). Overall, the use of obstetric maneuvers increased during the study period (from 25.7 to 97.0%, p < 0.001), which was associated with decreasing rate of Erb’s palsy and increasing use of ICD-10 code O66.0.

Conclusion
There are diagnostic pitfalls, which could be addressed by education regarding shoulder dystocia guidelines, by improved use obstetric maneuvers, and more precise documentation. The increased use of obstetric maneuvers was associated with lower rates of Erb’s palsy and improved coding of shoulder dystocia.
Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
Authors: Christensen Anders , Wessel Irene , Charabi Birgitte Wittenborg , Juhl Karina , Kiss Katalin , Lelkaitis Giedrius , Mortensen Jann , Kjaer Andreas , von Buchwald Christian , Tvedskov Jesper Filtenborg 
Published: April 2023

Abstract
Purpose
The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.

Methods
Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.

Results
In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.

Conclusion
Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
Primary cordierite with > 2.5 wt% CO2 from the UHT Bakhuis Granulite Belt, Surinam: CO2 fluid phase saturation during ultrahigh-temperature metamorphism
Authors: de Roever Emond W. F. , Harley Simon L. , Huizenga Jan M. 
Published: April 2023

AbstractThe Paleoproterozoic Bakhuis Granulite Belt (BGB) in Surinam, South America, shows ultrahigh-temperature metamorphism (UHTM) at temperatures of around 1000 °C which, unusually, produced peak-to-near-peak cordierite with sillimanite and, in some cases, Al-rich orthopyroxene on a regional scale. Mg-rich cordierite (Mg/(Mg + Fe) = 0.88) in a sillimanite-bearing metapelitic granulite has a maximum birefringence of second-order blue (ca. 0.020) indicative of a considerable amount of CO2 (> 2 wt%) within its structural channels. SIMS microanalysis confirms the presence of 2.57 ± 0.19 wt% CO2, the highest CO2 concentration found in natural cordierite. This high CO2 content has enabled the stability of cordierite to extend into UHT conditions at high pressures and very low to negligible H2O activity. Based on a modified calibration of the H2O–CO2 incorporation model of Harley et al. (J Metamorph Geol 20:71–86, 2002), this cordierite occupies a stability field that extends from 8.8 ± 0.6 kbar at 750 °C to 11.3 ± 0.65 kbar at 1050 °C. Volatile-saturated cordierite with 2.57 wt% CO2 and negligible H2O (0.04 wt%) indicates fluid-present carbonic conditions with a CO2 activity near 1.0 at peak or near-peak pressures of 10.5–11.3 kbar under UHT temperatures of 950–1050 °C. The measured H2O content of the cordierite in the metapelite is far too low to be consistent with partial melting at 1000–1050 °C, implying either that nearly all of any H2O originally in this cordierite under UHT conditions was lost during post-peak cooling or that the cordierite was formed after migmatization. The high level of CO2 required to ensure fluid saturation of the c. 11 kbar UHT cordierite is proposed to have been derived from an external, possibly mantle, source.