bluuebunny/crossref_metadata_2025_split huggingface dataset:
The four-factor personality model and its qualitative correlates among opioid agonist therapy clients
Authors: Mahu Ioan T. , Conrod Patricia J. , Barrett Sean P. , Sako Aïssata , Swansburg Jennifer , Stewart Sherry H. 
Published: June 2023

BackgroundThe Four Factor Personality Vulnerability model identifies four specific personality traits (e.g., sensation seeking [SS], impulsivity [IMP], anxiety sensitivity [AS], and hopelessness [HOP]) as implicated in substance use behaviors, motives for substance use, and co-occurring psychiatric conditions. Although the relationship between these traits and polysubstance use in opioid agonist therapy (OAT) clients has been investigated quantitatively, no study has examined the qualitative expression of each trait using clients’ voice.MethodNineteen Methadone Maintenance Therapy (MMT) clients (68.4% male, 84.2% white, mean age[SD] = 42.71 [10.18]) scoring high on one of the four personality traits measured by the Substance Use Risk Profile Scale [SURPS] completed a semi-structured qualitative interview designed to explore their lived experience of their respective trait. Thematic analysis was used to derive themes, which were further quantified using content analysis.ResultsThemes emerging from interviews reflected (1) internalizing and externalizing symptoms, (2) adversity experiences, and (3) polysubstance use. Internalizing symptoms subthemes included symptoms of anxiety, fear, stress, depression, and avoidance coping. Externalizing subthemes included anger, disinhibited cognitions, and anti-social and risk-taking behaviors. Adverse experiences subthemes included poor health, poverty, homelessness, unemployment, trauma, and conflict. Finally, polysubstance use subthemes include substance types, methods of use, and motives. Differences emerged between personality profiles in the relative endorsement of various subthemes, including those pertaining to polysubstance use, that were largely as theoretically expected.ConclusionPersonality is associated with unique cognitive, affective, and behavioral lived experiences, suggesting that personality may be a novel intervention target in adjunctive psychosocial treatment for those undergoing OAT.
Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate
Authors: Erchinger Vera J. , Craven Alexander R. , Ersland Lars , Oedegaard Ketil J. , Bartz-Johannessen Christoffer A. , Hammar Åsa , Haavik Jan , Riemer Frank , Kessler Ute , Oltedal Leif 
Published: June 2023

IntroductionBased on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic mechanism of ECT. This model implies that a temporary disturbance of neuronal networks (disruption) is followed by a trophic effect (potentiation), which enables the rewiring of neuronal circuits to a more euthymic functioning brain. We hypothesized that disruption of neuronal networks could trigger biochemical alterations leading to a temporary decrease in N-acetylaspartate (tNAA, considered a marker of neuronal integrity), while choline (a membrane component), myo-Inositol (mI, astroglia marker), and glutamate/glutamine (Glx, excitatory neurotransmitter) were postulated to increase. Previous magnetic resonance spectroscopy studies, reporting diverse findings, have used two different referencing methods - creatine ratios and tissue corrected values referenced to water – for the quantification of brain metabolites. Changes in creatine during ECT have also been reported, which may confound estimates adopting this as an internal reference.MethodsUsing MR spectroscopy, we investigated 31 moderately to severely depressed patients and 19 healthy controls before, during, and after ECT or at similar time points (for controls). We tested whether biochemical alterations in tNAA, choline, mI, and Glx lend support to the disrupt, potentiate, and rewire hypothesis. We used both creatine ratios and water-scaled values for the quantification of brain metabolites to validate the results across referencing methods.ResultsLevels of tNAA in the anterior cingulate cortex decreased after an ECT treatment series (average 10.6 sessions) by 6% (p = 0.007, creatine ratio) and 3% (p = 0.02, water referenced) but returned to baseline 6 months after ECT. Compared to after treatment series tNAA levels at 6-month follow-up had increased in both creatine ratio (+6%, p &lt; 0.001) and water referenced data (+7%, p &lt; 0.001). Findings for other brain metabolites varied and could not be validated across referencing methods.DiscussionOur findings suggest that prior research must be interpreted with care, as several referencing and processing methods have been used in the past. Yet, the results for tNAA were robust across quantification methods and concur with relevant parts of the disrupt, potentiate, and rewire model.
Critical national response in coping with Omicron variant in China, Israel, South Africa, and the United States
Authors: Jiao Jun , Shi Leiyu , Chen Haiqian , Wang Xiaohan , Yang Manfei , Yang Junyan , Liu Meiheng , Sun Gang 
Published: June 2023

ObjectiveThe aim of this study was to analyze the effectiveness of prevention and control strategies and put forward further measures according to the epidemiological characteristics of Omicron. It summarized the national response during the Omicron epidemic in four countries: China, Israel, South Africa, and the United States.MethodsThis study summarized prevention and control measures in China, Israel, South Africa, and the United States in their response to the Omicron epidemic, and it also evaluated the effectiveness of these measures.ResultsAfter the Omicron variant emerged, China and Israel adopted containment strategies, using the “dynamic zero” policy and country closure measures. Meanwhile, South Africa and the United States adopted mitigation strategies, which virtually abandoned social interventions and only focused on medical measures and vaccines. From the first day of reported Omicron cases to 28 February 2022, the four countries reported the following cases: China reported 9,670 new confirmed cases and no deaths, with total deaths per million of 3.21; Israel reported 2,293,415 new confirmed cases and 2,016 deaths, with total deaths per million of 1,097.21; South Africa reported 731,384 new confirmed cases and 9,509 deaths, with total deaths per million reaching 1,655.708; the United States reported 3,042,743 new confirmed cases and 1,688,851 deaths, with total deaths per million reaching 2,855.052, which was much higher than the other countries.ConclusionBased on this study, it seems that China and Israel adopted containment strategies, while South Africa and the United States adopted mitigation strategies. A rapid response is a powerful weapon against the Omicron epidemic. Vaccines alone will not get any country out of this crisis, and non-pharmacological measures should be used in addition to them. According to the SPO model, future work should consider the strengthening of emergency management capacity, adhering to public health measures, promoting vaccination, and strengthening patient care and close contact management, which are effective measures in coping with Omicron.
Effectiveness of the Program to Encourage Active, Rewarding Lives (PEARLS) to reduce depression: a multi-state evaluation
Authors: Smith Matthew Lee , Steinman Lesley E. , Montoya Carol N. , Thompson Meghan , Zhong Lixian , Merianos Ashley L. 
Published: June 2023

IntroductionAn estimated 15% of community-dwelling older adults have depressive symptoms in the U.S. The Program to Encourage Active, Rewarding Lives (PEARLS) is an evidence-based program for managing late-life depression. PEARLS is a home/community-based collaborative care model delivered by community-based organizations to improve access to quality depression care. Trained staff actively screen for depression to improve recognition, teach problem-solving and activity planning skills for self-management, and connect participants to other supports and services as needed.MethodsThis study examined 2015–2021 data from 1,155 PEARLS participants across four states to assess PEARLS effectiveness to reduce depressive symptoms. The clinical outcomes were measured by the self-reported PHQ-9 instrument to assess changes in depressive symptoms scored as depression-related severity, clinical remission, and clinical response. A generalized estimating equation (GEE) model was fitted to examine changes in composite PHQ-9 scores from baseline to the final session. The model adjusted for participants’ age, gender, race/ethnicity, education level, income level, marital status, number of chronic conditions, and number of PEARLS sessions attended. Cox proportional hazards regression models were conducted to estimate the hazard ratio for improvement of depressive symptoms (i.e., remission or response), while adjusting for the covariates.ResultsPHQ-9 scale scores significantly improved from baseline to their final sessions (mean difference = −5.67, SEM = 0.16, p &lt; 0.001). About 35% of participants achieved remission with PHQ-9 score &lt; 5. Compared to participants with mild depression, patients with moderate depression (HR = 0.43, 95%CI = 0.35–0.55), moderately severe depression (HR = 0.28, 95%CI = 0.21–0.38), and severe depression (HR = 0.22 95%CI = 0.14–0.34) were less likely to experience clinical remission with PHQ-9 score &lt; 5, while adjusting for the covariates. About 73% achieved remission based on no longer having one or both cardinal symptoms. Compared to participants with mild depression, patients with moderate depression (HR = 0.66, 95%CI = 0.56–0.78), moderately severe depression (HR = 0.46, 95%CI = 0.38–0.56), and severe depression (HR = 0.38, 95%CI = 0.29–0.51) were less likely to experience clinical remission, while adjusting for the covariates. Nearly 49% of participants had a clinical response or a ≥ 50% decrease in PHQ-9 scores over time. There were no differences between the severity of depression groups based on the time to clinical response.DiscussionFindings confirm that PEARLS is an effective program to improve depressive symptoms among older adults in diverse real-world community settings and can be a more accessible option for depressive older adults who are traditionally underserved by clinical care.
Functional semi-finished fish product evaluation: organoleptic and evidence in vivo
Authors: Moldagaliyeva Dinara , Uzakov Yasin , Sarsembayeva Nurzhan , Ibazhanova Assem , Jussipbekova Balzhan , Nurakhova Alma , Artykbayeva Ulbobek , Baimuratova Mairash 
Published: June 2023

IntroductionThe development of functional products is a new promising trend in the modern food industry. The research aims to confirm the quality indicators, efficacy and safety for living organisms of the developed functional semi-finished fish product—raw smoked sausage. The research was aimed at studying the characteristics of the semi-finished product obtained, including its organoleptic properties. However, it was also important to test the properties of the probiotic component added to the developed product and its effects in vivo on mice to verify the efficacy and safety of the E. coli 64 G strain.MethodsOrganoleptic and histological assessments of the product were performed. A series of experiments were also conducted to assess the product’s safety and functional properties. For this purpose, Enteracol was fed to white outbred laboratory mice with different concentrations of the active ingredient (Escherichia coli 64G strain). Organoleptic properties of the proposed product, such as smell, consumer view, and balanced taste, demonstrated high consumer qualities of the crude smoked sausage with a probiotic component.ResultsThe results of the controlled prospective study confirmed that the product is safe and non-toxic to living organisms: mice state alive after consuming a created meal. At the same time, assessing the product’s antagonistic activity revealed its high protective effect (85%–100% survival rate of animals in the experimental groups compared to the control with 100% mortality).DiscussionThe proposed product has a stimulating effect on an organism and demonstrates the antagonistic activity against pathogenic and opportunistic bacteria established in the Enterobacteriaceae family members. The next step will be a long-term study of the product’s stimulating effect to prove its positive impact on the body.
Effects of sources and levels of dietary supplementary manganese on growing yak’s in vitro rumen fermentation
Authors: Lu Huizhen , Liu Pengpeng , Liu Shujie , Zhao Xinsheng , Bai Binqiang , Cheng Jianbo , Zhang Zijun , Sun Cai , Hao Lizhuang , Xue Yanfeng 
Published: June 2023

IntroductionManganese (Mn) is an essential trace element for livestock, but little is known about the optimal Mn source and level for yak.MethodsTo improve yak’s feeding standards, a 48-h in vitro study was designed to examine the effect of supplementary Mn sources including Mn sulfate (MnSO4), Mn chloride (MnCl2), and Mn methionine (Met-Mn) at five Mn levels, namely 35 mg/kg, 40 mg/kg, 50 mg/kg, 60 mg/kg, and 70 mg/kg dry matter (includes Mn in substrates), on yak’s rumen fermentation.ResultsResults showed that Met-Mn groups showed higher acetate (p &lt; 0.05), propionate, total volatile fatty acids (p &lt; 0.05) levels, ammonia nitrogen concentration (p &lt; 0.05), dry matter digestibility (DMD), and amylase activities (p &lt; 0.05) compared to MnSO4 and MnCl2 groups. DMD (p &lt; 0.05), amylase activities, and trypsin activities (p &lt; 0.05) all increased firstly and then decreased with the increase of Mn level and reached high values at 40–50 mg/kg Mn levels. Cellulase activities showed high values (p &lt; 0.05) at 50–70 mg/kg Mn levels. Microbial protein contents (p &lt; 0.05) and lipase activities of Mn-Met groups were higher than those of MnSO4 and MnCl2 groups at 40–50 mg/kg Mn levels.DiscussionTherefore, Mn-met was the best Mn source, and 40 to 50 mg/kg was the best Mn level for rumen fermentation of yaks.
CKD Associates with Cognitive Decline in Middle-Aged and Older Adults with Long-Standing Type 1 Diabetes
Authors: Khatri Minesh , Ryan Christopher M. , Gao Xiaoyu , de Boer Ian H. , Braffett Barbara H. , Molitch Mark , Karger Amy B. , Lorenzi Gayle M. , Lee Pearl , Trapani Victoria R. , Lachin John M. , Jacobson Alan M. 
Published: June 2023

Key Points

We found that development of both albuminuria and reduced eGFR was associated with clinically significant cognitive decline, particularly in the psychomotor and mental efficiency domain.There was also a significant interaction between worsened albuminuria and eGFR, the combination of which augmented cognitive deficits.A more comprehensive longitudinal phenotype of albuminuria showed that regressed albuminuria did not associate with worsened cognitive decline, as opposed to persistent albuminuria.

Background
Individuals with CKD or type 1 diabetes (T1D) are at risk for cognitive decline, but it is unclear whether these associations are with albuminuria, eGFR, or both.

Methods
We examined the longitudinal relationships between CKD and change in cognition in 1051 participants with T1D in the Diabetes Control and Complications Trial and its follow-up, the Epidemiology of Diabetes Interventions and Complications study. Albumin excretion rate and eGFR were measured every 1–2 years. Three cognitive domains were assessed repeatedly over a 32-year period: immediate memory, delayed memory, and psychomotor and mental efficiency. Associations between cognitive function and CKD were assessed: (1) longitudinally and (2) in models using eGFR and albuminuria measurements over the first 15–20 years with subsequent change in cognitive function over the ensuing 14 years (when decline in cognition was greatest).

Results
In fully adjusted longitudinal analyses, the magnitude of decline in the psychomotor and mental efficiency domain score was associated with eGFR <60 ml/min per 1.73 m2 (β −0.449; 95% confidence interval [CI], −0.640 to −0.259) and sustained albumin excretion rate 30 to <300 mg/24 hours (β −0.148; 95% CI, −0.270 to −0.026). This was equivalent to a decrease associated with approximately 11 and 4 years of aging, respectively. In analyses focused on changes in cognition between study years 18 and 32, eGFR <60 ml/min per 1.73 m2 was associated with reduced psychomotor and mental efficiency (β −0.915; 95% CI, −1.613 to −0.217).

Conclusions
In T1D, development of CKD was associated with a subsequent reduction on cognitive tasks requiring psychomotor and mental efficiency. These data highlight the need for increased recognition of risk factors for neurologic sequelae in patients with T1D, as well as preventive and treatment strategies to ameliorate cognitive decline.
Multiview Clustering to Identify Novel Kidney Donor Phenotypes for Assessing Graft Survival in Older Transplant Recipients
Authors: Raza Abidi Syed Sibte , Naqvi Asil , Worthen George , Vinson Amanda , Abidi Samina , Kiberd Bryce , Skinner Thomas , West Kenneth , Tennankore Karthik K. 
Published: June 2023

Key Points

An unsupervised machine learning clustering algorithm identified distinct deceased kidney donor phenotypes among older recipients.Recipients of certain donor phenotypes were at a relatively higher risk of all-cause graft loss even after accounting for recipient factors.The use of unsupervised clustering to support kidney allocation systems may be an important area for future study.

Background
Older transplant recipients are at a relatively increased risk of graft failure after transplantation, and some of this risk may relate to donor characteristics. Unsupervised clustering using machine learning may be a novel approach to identify donor phenotypes that may then be used to evaluate outcomes for older recipients. Using a cohort of older recipients, the purpose of this study was to (1) use unsupervised clustering to identify donor phenotypes and (2) determine the risk of death/graft failure for recipients of each donor phenotype.

Methods
We analyzed a nationally representative cohort of kidney transplant recipients aged 65 years or older captured using the Scientific Registry of Transplant Recipients between 2000 and 2017. Unsupervised clustering was used to generate phenotypes using donor characteristics inclusive of variables in the kidney donor risk index (KDRI). Cluster assignment was internally validated. Outcomes included all-cause graft failure (including mortality) and delayed graft function. Differences in the distribution of KDRI scores were also compared across the clusters. All-cause graft failure was compared for recipients of donor kidneys from each cluster using a multivariable Cox survival analysis.

Results
Overall, 23,558 donors were separated into five clusters. The area under the curve for internal validation of cluster assignment was 0.89. Recipients of donor kidneys from two clusters were found to be at high risk of all-cause graft failure relative to the lowest risk cluster (adjusted hazards ratio, 1.86; 95% confidence interval, 1.69 to 2.05 and 1.73; 95% confidence interval, 1.61 to 1.87). Only one of these high-risk clusters had high proportions of donors with established risk factors (i.e., hypertension, diabetes). KDRI scores were similar for the highest and lowest risk clusters (1.40 [1.18–1.67] and 1.37 [1.15–1.65], respectively).

Conclusions
Unsupervised clustering can identify novel donor phenotypes comprising established donor characteristics that, in turn, may be associated with different risks of graft loss for older transplant recipients.
Pelatihan Peningkatan Branding dan Optimalisasi Pemasaran Produk Lokal Menuju Produk Internasional pada UKM Nasi Tiwul SBR Malang
Authors: Kristanto Titus , Rahmawati Dewi , Endah Wahyuni Ayu , Nasrullah Muhammad , Arindra Fadillah Reza , Amalia Amanda 
Published: June 2023

Dampak pandemi COVID-19 mengakibatkan banyak pekerja kehilangan pekerjaan, sehingga terjadi pengangguran dan pengurangan karyawan, maka perlu mencari sumber potensi pendapatan baru yang dapat dieksplorasi dari lingkungan sekitar. Salah satu cara yaitu penerapan metode peningkatan branding dan optimalisasi pemasaran produk lokal menuju produk internasional. Tujuan dari kegiatan pengabdian adalah memberdayakan UMKM lokal agar hasil produk yang dihasilkan lebih efektif dan memperoleh hasil maksimal berupa desain kemasan produk dan memanfaatkan media pemasaran digital. Kegiatan pengabdian sejalan dengan program Pemerintah terkait peningkatan ketahanan pangan di Indonesia. Berdasarkan hasil diskusi dari pemilik UMKM, permasalahan yang dihadapi adalah aktivitas pemasaran produk lokal pada tingkat nasional. Aktivitas peningkatan branding dan optimalisasi pemasaran produk lokal menuju produk internasional dapat menjadi solusi alternatif untuk mengatasi masalah, terutama masalah yang dihadapi pemilik usaha Nasi Tiwul SBR Malang terkait pemasaran produk terbatas pada lingkungan sekitar. Metode peningkatan branding dan optimalisasi pemasaran produk lokal menuju produk internasional sangat sederhana yaitu mengetahui cara dan strategi dalam memasarkan produk secara tepat dan terarah. Melakukan pemasaran produk ke luar negeri dapat dilakukan dengan mudah melalui media digital. Saat ini, akses komunikasi dan penyebaran informasi dari seluruh dunia dapat dilakukan melalui internet, termasuk memperkenalkan bisnis ke luar negeri. Diharapkan dalam 6 bulan sudah mendapatkan hasil dan dapat dijual langsung pada wilayah Malang dan sekitarnya, sehingga produk lokal Indonesia dikenal dunia.
Investigating performance optimization through balanced task scheduling heuristics and DVFS in hybrid fog-cloud computing platforms
Authors: Bansal Savina 
Published: June 2023

<p>In the evolving landscape of fog-cloud hybrid computing, efficient task scheduling plays a vital role in meeting real-time requirements while optimizing resource utilization and energy consumption. This work proposes balanced minimum response time (MRT) and balanced minimum energy consumption (MEC) heuristics to address the challenges of task allocation on hybrid computing platforms in a balanced manner. These heuristics are employed to assess the efficacy of complementing cloud or fog networks, supported by dynamic voltage and frequency scaling (DVFS), leveraging deadline laxities without compromising user satisfaction. Three hybrid computing sub-scenarios are introduced: cloud-oriented, fog-oriented, and balanced-hybrid, based on the relative compute capacity of fog and cloud networks. The results reveal that a cloud network complementing a fog network is more beneficial for achieving lower makespan, while for lower energy consumption, it is preferable for fog network to complement the cloud network. The research emphasizes the advantages of balanced heuristics under different computing scenarios to optimize makespan, energy consumption, and workload allocation, leading to overall computing cost reduction using realistic workloads. Further, judiciously applying DVFS to low-capacity fog nodes is more fruitful than powerful cloud nodes due to extravagant idle energy consumption in the generated scheduling holes. </p>
Membangun Islam Pluralis dan Inklusif Telaah Atas Konsep Historisitas dan Dekonstruksi Mohammad Arkoun
Authors: Basid Abdul 
Published: June 2023

Islam sebagai agama meniscayakan adanya pembacaan dan kajian yang terus berkembang. Kajian tersebut dimulai dari titik masuk dan pendekatan yang berbeda, sehingga wajar ketika mulai sejarah awal munculnya Islam terdapat berbagai macam aliran pemikiran keagamaan Islam terus semakin bertambah. Tentunya pemahaman yang dilakukan tidak bisa dilepaskan dari kaca mata dan pendekatan yang dipakai sehingga melahirkan beragam pemahaman. Arkoun termasuk salah satu dari sederet tokoh yang mencoba untuk mengusulkan metode pendekatan baru untuk melakukan pembacaan yang lebih bijak dan terbuka dengan metode historisitas dan dekonstruksi.