bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of frailty and its relationship with socio-demographic factors, regional healthcare disparities, and healthcare utilisation in the aging population across India
Authors: Singhal Sunny , Singh Sumitabh , Dewangan Gevesh Chand , Dey Sharmistha , Banerjee Joyita , Lee Jinkook , Upadhyaya Ashish Datt , Hu Peifeng , Goyal Laxmi Kant , Dey A B 
Published: December 2022

Abstract
Background
The burden of frailty in developing countries and its relationship with complex social structures, such as caste, religion and regional healthcare differences and its effect on healthcare outcomes are not well characterized. The aim of the study was to estimate frailty prevalence and its relationship with the socio-economic and regional factors and healthcare outcomes.
Methods
In this study, participants from the harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) were included. The frailty index (FI) was calculated using a 32-variable deficit model, with a value of ≥ 25% considered as frail. Data on demographic (including caste and religion) and socioeconomic profiles and healthcare utilization were obtained. The state-wise health index maintained by the government based on various health-related parameters was used to group the participants’ residential states into high-, intermediate-, and low-performing states. Multivariable and zero-inflated negative binomial regression was used to assess the relationship of frailty index with socio-demographic characteristics, health index and healthcare expenditure or hospitalization.
Results
Among the 3,953 eligible participants, the prevalence of frailty was 42.34% (men: 34.99%; women: 49.35%). Compared to high-performing states, intermediate- and low-performing states had a higher proportion of frail individuals (49.7% vs. 46.8% vs. 34.5%, p < 0.001). In the adjusted analysis, frailty was positively associated with age, female sex, rural locality, lower education level, and caste (scheduled caste and other backward classes). After adjusting for socio-economic profile, FI was inversely associated with the composite health index of a state (p < 0.001). FI was also significantly correlated with total one-year healthcare expenditure and hospitalization (p-value = < 0.001 and 0.02 respectively).
Conclusion
There is a high prevalence of frailty among older Indian adults that is associated with socio-demographic factors and regional healthcare performance. Furthermore, frailty is associated with increased healthcare utilization and expenditure.
Targeting UBR5 inhibits postsurgical breast cancer lung metastases mediated by CDC73 and p53
Authors: Ma Xiaojing , Yu Ziqi , Dong Xue , Song Mei , Xu Aizhang , He Qing , Li Huilin , Ouyang Wen , Chouchane Lotfi 
Published: December 2022

Abstract
UBR5 is a HECT domain E3 ubiquitin ligase that is frequently amplified in breast, ovarian, and prostate cancers. Heightened UBR5 plays an oncogenic role in promoting tumor growth through immune-dependent mechanisms. However, its mode of action in driving tumor metastasis has not been definitively delineated. In this study, we used a tetracycline (Tet)-inducible RNAi-mediated expression silencing cell system to investigate how UBR5 enables postsurgical mammary tumor metastatic growth in the lungs of mice without the impact of the primary lesion. In vitro, Ubr5 knockdown induced morphological and molecular changes characteristic of epithelial-mesenchymal transition (EMT). In vivo, UBR5 promoted lung metastasis in an E3 ubiquitin ligase-dependent manner. Moreover, doxycycline-induced knockdown of UBR5 expression in metastatic cells in the lung resulted in increased apoptosis, decreased proliferation, and prolonged survival, whereas silencing the expression of cell division cycle 73 (CDC73), a tumor suppressor and an E3 ligase substrate of UBR5, reversed these effects. Transcriptome analyses revealed a prominent role for the p53 pathway in dovitinib-induced apoptosis of tumor cells differentially regulated by UBR5 and CDC73. In human triple-negative breast cancer (TNBC) patient specimens, a strong inverse correlation was observed between UBR5 and CDC73 protein levels and reduced CDC73 expression at metastatic sites compared to primary lesions. Furthermore, a xenograft model of human TNBC recapitulated the metastatic properties and characteristics of the unique UBR5-CDC73 functional antagonism. This study unveils the novel and critical roles and relationships of UBR5, CDC73 and p53 in postsurgical breast cancer metastasis and implicates the potential of targeting this pathway in cancer therapy.
Anxiety, Depression and Quality of Life After Achievement of Inactive/Low Disease Activity in Axial-Spondyloarthropathy
Authors: Bayrak Esra Dilsat , Aktas Ilknur 
Published: December 2022

Abstract
Objectives
Axial-Spondylorthropathy (axSpA) is a common rheumatic disease in young and working age population and has an important physicosocial effects. The aim of this study is to investigate the frequency of anxiety and depression in axSpA patients who has inactive/low disease activity, explore the factors associated with anxiety and depression and whether the anti-TNF agents have an positive effect on anxiety-depression and QOL.
Methods
AxSpA patients who met the criteria for inactive or low disease activity according to ASDAS were included in the study. Baseline characteristics were recorded. Patients recieving anti-TNF and NSAID treatments were compared. Anxiety and depression were assessed by Hospital Anxiety and Depression Scale (HADS). QOL was measured with the EuroQOL (EQ5D).
Results
33.6% of patients were assessed for having probable anxiety and 47% for probable depression. There were no differences in terms of age, marital status, employement, positive family history, peripheral arthritis, enthesitis, mean HADS-A, HADS-D and EUROQOL between anti-TNF and NSAID teratments. Positive family history, peripheral arthritis and higher BASDAI were predictive for probable anxiety. Peripheral arthritis and higher BASDAI were predictive for probable depression. EUROQOL was correlated with high BASDAI, BASFI, HADS-A, HADS-D, peripheral arthritis and positive family history.
Conclusion
Regular psychosocial assessment should be the part of treatment of axSpA patients besides the control of disease activity and inflammation.
Aesthetic Oral rehabilitation with Digital cast partial denture, FPD and Composite restorations – A case report
Authors: Pradeep C , Lahori Manesh , Agarwal Abhinav 
Published: December 2022

Abstract
One of the conservative and affordable choices for treating partially edentulous arches that can improve quality of life overall is removable partial dentures.
However, the laboratory procedures involved in its fabrication are complex, time-consuming, and require manual dexterity.
The two methods of digitization used in RPD framework development are subtractive and additive methods. Using a computer numerical control machine, subtractive manufacturing entails machining the framework out of a metal block.
The fixed prosthesis is well adapted to the subtractive techniques. Due to longer manufacturing times, the complexity of the framework, the cost of the materials, and wear, their implementation is more challenging to build RPD framework.
This case report presents rehabilitation of a partially edentulous maxillary arch with DMLS co-cr Cast Partial Denture.
A fault feature extraction method of gearbox considering variable speed condition
Authors: Li Siyu , Cheng Zhonghua , Liu Zichang , Wang Yabin , Jia Xisheng 
Published: December 2022

Abstract
In this paper, a fault feature extraction method based on the combination of COT and VMD is proposed to solve the problem of fault feature extraction of gearbox under variable speed conditions. Firstly, a speed estimation method based on forward backward greedy algorithm and Fourier fitting is proposed to solve the speed estimation problem under variable speed conditions. Then, a feature extraction method based on computational order tracking (COT), variational mode decomposition (VMD) and fast kurtogram is proposed. COT is used to calculate the order. After the signal is decomposed by VMD, fast kurtogram is used to filter the modal components with obvious fault features, so as to extract fault features. Finally, combined with the analysis of actual equipment examples, the experimental results show that the steady state filtering can effectively filter the background noise and improve the signal-to-noise ratio. The rotation speed estimated by forward backward greedy algorithm and Fourier fitting is very close to the actual speed, which verifies that the method proposed in this paper can effectively solve the problem of fault feature extraction of gearbox under variable speed conditions.
Enhanced Removal of Organic and Inorganic Pollutants using Electrooxidation Integrated Membrane Bioreactor (IMBR) and validation through Lumped Parameter Kinetic modelling with thermodynamic parameter exploration in Pharmaceutical Wastewater Treatment
Authors: Palani Kavitha Nagrasampatti , Saravanakumar Naveen Kumar , Natesan Balsubramanian 
Published: December 2022

Abstract

The occurrence of fouling in Membrane Bioreactors (MBRs).reduces the performance of the system can be overcome by integrating electro-oxidation process in which different applied current density (CD) have been investigated. The optimal CD was 0.748 A/m2 which was suitable for the long-time operation of IMBR and observed that the removal percentile for total organic compounds (TOC), chemical oxygen demand (COD) was above 90% with total dissolved solids (TDS) of 60% at 400kPa constant pressure. Scanning electron micrographs (SEM) showed less void volume and pore constriction and the increase in permeate flux was 45% with extended backwashing time of 140 minutes. The fouling mechanism also verified by Hermia models, lumped parameter kinetic modelling and thermodynamic parameter with activation energy estimation exhibits lesser internal fouling of standard error 0.00459, 58.296 kJ/mol, − 0.1191 kJ/mol, 94.621 kJ/mol, 52.428 kJ/mol and the observed results and more reliable and feasible. The most striking observations in this study were that IMBR can be operated without the problem of filamentous bulking, and electro-oxidation significantly alternated the structural and morphological sludge flocs. The results implied that electro-oxidation might be the key factor for the success in fouling mitigation in IMBR.
Wood dust as an additive for starch-based biocomposite films
Authors: Kwaśniewska Anita , Świetlicki Michał , Kowalska Beata , Gładyszewski Grzegorz 
Published: December 2022

Abstract
The study aimed to investigate the effect of raw waste pine wood dust (Pinus sylvestris) from furniture production on polysaccharide biopolymer film properties. The obtained biocomposite films produced by the casting method were prepared with 20% glycerol and 0%, 5%, 10%, 15%, 20% and 25% of added wood dust in relation to the dry starch matter, respectively. Wood dust composition and particle size distribution analysis were performed. In order to evaluate the material surface properties, tests were carried out using an atomic force microscope (AFM) and a contact angle goniometer. The uniaxial tensile test examined the mechanical properties, and the tensile strength and Young’s modulus value were determined. In addition, the barrier properties, water solubility index and colour were also investigated. The research showed that wood dust affects the functional parameters of the obtained biocomposites. Wood dust content increase causes Young’s modulus value to rise with a progressive decrease in the max strain. The filler did not change the films’ wetting properties, and each had a hydrophilic surface regardless of the additive amount. The bio-sourced composites obtained are non-toxic and environmentally neutral materials suitable to apply in the packaging industry as well as the agriculture sector.
Importance of Trade Integration and Trade Complementarity inflow on the relationship between China and Europe &amp; Central Asia
Authors: Shahzad Umer 
Published: December 2022

Abstract
The study aim is to investigate the Industrial, Agricultural, and Technological Bilateral Trade relationship between China and the Europe & Central Asia region over the period of 2000 to 2019 by employing the Revealed Comparative Advantage Index (RCA export), Trade Complementarity Index (TCI) and Trade Integration Index (TCD). The estimated results showed that there is a strong Bilateral Trade relationship between China and Europe & Central Asia. The estimated results of the Trade Complementarity Index (TCI) indicates that between 20 industries' product 17 have strong TCI between China and Europe, which showed that the export and import between China and Europe & Central Asia are matched, only three of the industries product, which are vegetable, Fuels, and Minerals are not matched strongly, the Trade Integration Index (TCD) between China and Europe from 2000 to 2019 is less than 1 that explains the Trade Integration Index between China and Europe are weak which give us knowledge that Chinese trade didn’t depend strongly on the Europe & Central Asia, estimated results of the Revealed Comparative Advantage Index (RCA export) between China and Europe examine that there have strong the Revealed Comparative Advantage between China and Europe of all 20 different industries product.
Optimization of HVAC Energy usage with Building Automation and Control Systems in Tropical Climates: a Review
Authors: Gaba Navneet 
Published: December 2022

Abstract
Improving the energy performance of buildings will be essential for countries around the world to reduce energy consumption and emissions. Building automation and control systems (BACS) play a crucial role in achieving this objective. Heating, ventilating and air conditioning (HVAC) systems are primary targets for improving energy efficiency through automation. In tropical and subtropical regions with high average temperatures cooling in commercial buildings such as offices has become essential for thermal comfort. This paper focuses on a comprehensive understanding of building automation and control systems as well as an analysis of their use in reducing HVAC energy consumption in commercial buildings utilizing available data and literature resources. A survey of 23+7 research papers and 2 books was carried out to understand the scope of HVAC energy optimization in commercial buildings with the use of BACS. The purpose of this paper is to raise awareness of these BACS systems and the significance of their application for energy optimization in buildings. The Heating, Ventilation, and Air Conditioning (HVAC) system of a commercial building is one of the largest energy consumers, especially in tropical climates. Building automation and control systems (BACS) are one of the most important enabling technologies for energy-efficient HVAC control in buildings. Automated starting and stopping of HVAC equipment reduces system operating hours, maintenance costs, energy costs and greenhouse gas (GHG) emissions, thereby reducing the building's carbon footprint while maintaining occupant comfort. This results in savings in the thousands of dollars annually.
The Effect of Scattered Multipurpose Trees (Erythrina Brucei Schweinf. And Croton Macrostachyus Hochst. Ex Delile) on Wheat (Triticum Aestivum L.) Yield in Southern Ethiopia
Authors: Bekele Daba Misgana , Hagos Tesfay Hailemarium , Selfeko Dereje Tsegaye 
Published: December 2022

Abstract

Integrating multipurpose trees on cropland with annual crops is common in Ethiopia. However, information on its impact on annual crop yield is scarce in many parts of the region. This study was to evaluate the effect of Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) and Erythrina brucei Schweinf. (Fabaceae) on wheat crop yield in southern Ethiopia, Gamo Zone, Chencha district, Ayira kebele. Ayira kebele was selected purposively based on having abundant trees on cropland. Eight trees were selected based on having an approximately similar diameter at breast height, height, and crown area from a similar site. The wheat crops was sown under the canopy and outside the canopy of the selected trees and the biomass and yield were collected from 1/3m crown radius, 2/3m crown radius, edge of the crown, and outside the canopy of the trees by establishing 0.5m*0.5m plot. The wheat yields and biomass results were analyzed using two-way ANOVA by SAS Software version 9.0 and mean separation with LSD (%) at a 5% level of significance. The combined analysis of the variance of the study showed that the effect of the two tree species on the biomass and grain yield of wheat was significantly (P< 0.05) higher within the canopy of the tree than outside of the canopy. The findings of the present study will be helpful in knowing the effect of Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) and Erythrina brucei Schweinf. (Fabaceae) on wheat yield. In this study, we found that both tree species would be incorporated into wheat cropping systems to improve the yield of wheat crops for resource-poor farmers as scattered multipurpose trees can be used as an economically feasible, environmentally friendly, and sustainable alternative production. Since both trees have a positive effect on wheat grain yield and plant biomass, expanding the knowledge of these trees in cropland is recommended.
The necessary and sufficient conditions for the real Jacobian conjecture
Authors: Tian Yuzhou , Zhao Yulin 
Published: December 2022

Abstract
We focus on investigating the real Jacobian conjecture. This conjecture claims that if F = (ƒ1 , . . . , ƒn) : Rn → Rn is a polynomial map such that det DF ≠ 0, then F is a global injective. In Euclidean space Rn, the Hadamard’s theorem asserts that the polynomial map F with det DF ≠ 0 is a global injective if and only if ∥ F (x) ∥ approaches to infinite as ∥ x ∥ → ∞. This paper consists of two parts. The first part is to study the two-dimensional real Jacobian conjecture via the method of the qualitative theory of dynamical systems. We provide some necessary and sufficient conditions such that the two-dimensional real Jacobian conjecture holds. By Bendixson compactification, an induced polynomial differential system can be obtained from the Hamiltonian system associated to polynomial map F. We prove that the following statements are equivalent: (A) F is a global injective; (B) the origin of induced system is a center; (C) the origin of induced system is a monodromic singular point; (D) the origin of induced system has no hyperbolic sectors; (E) induced system has a Ck first integral with an isolated minimun at the origin and k ∈ N+∪{∞}. The above conditions (B)-(D) are local dynamical conditions. Moreover, applying the above results we present a very elementary dynamical proof of the two-dimensional Hadamard’s theorem.
In the second part, we give an alternate proof of the Cima’s result on the n-dimensional real Jacobian conjecture by the n-dimensional Hadamard’s theorem
2020 Math Subject Classification: Primary 34C05. Secondary 34C08. Tertiary 14R15
Cytomorphometric assessment and micronuclei assay in iron deficiency anemic females – An Exfoliative Cytological Study
Authors: Rehani Shweta , Bala Jyoti , Bishen Kundendu Arya , Juneja Vishal , Sethi Sneha 
Published: December 2022

Abstract
Background: The ubiquitous form of iron is an essential nutrient for most tissues and its deficiency brings about recognizable deleterious effect on various tissues. Oral manifestation in iron deficiency anemia (IDA) are frequent and significant indicator of the underlying disease.
Aims: The aim of this study was to determine quantitative cytological changes in exfoliative buccal smears of iron deficiency anemic subjects, followed by a comparison with a control group on the basis of various morphometric parameters.
Material and methods: The study included 40 subjects (females with IDA) and 40 apparently healthy subjects (age range 6 – 60 years). Papanicolaou and Giemsa stained smears were prepared from the exfoliated buccal mucosal samples. The quantitative assessment of cellular diameter (CD), nuclear diameter (ND) and nuclear to cellular ratio (N:C) was done using Image J analysis software version 1.49t and average micronuclei count of 100 clearly defined unfolded epithelial cells for each subject was evaluated under light microscopy.
Results: This study shows that compared to the control group, IDA females for all age groups exhibited features like lower mean CD, higher mean ND, higher mean N: C ratio and increased average micronuclei count.
Conclusions: IDA brings about cytological changes in oral mucosa and the present study further substantiates this existing fact. Through the use of exfoliative smears, the early diagnosis, regular monitoring and post medication follow-up will have better patient compliance. Thus dental professionals should be encouraged to incorporate exfoliative cytology in their diagnostic aids.
Clinicopathological features and survival outcomes of colorectal medullary carcinoma: a retrospective study based on the SEER database
Authors: Han Lu , Zhang Yaping , Zhang Qun , Hu Jing , Li Li , Shi Xiao , Ding Zhou , Qian Xiaoping 
Published: December 2022

Abstract
Object: To investigate the relationship between clinicopathological characteristics and survival prognosis of patients with colorectal medullary carcinoma (MC), and to compare the prognostic differences between MC, colorectal neuroendocrine carcinoma (CRC-NEC) and colorectal neuroendocrine tumor (CRC-NET), in order to provide a more targeted treatment plan for colorectal cancer (CRC) and provide an evidence-based basis for evaluating the prognosis of patients. To provide a more targeted treatment plan for colorectal cancer (CRC) and an evidence-based basis for evaluating patient prognosis.
Methods: From 2010 to 2019, 495 patients with pathological diagnosis of MC, 2440 patients with CRC-NEC and 9626 patients with CRC-NET were collected from the SEER database. The differences in clinicopathological characteristics between the groups were compared and the corresponding survival curves were plotted. 1:1 Propensity Score Matching (PSM) was used to eliminate the differences in baseline information between the groups, and the Kaplan-Meier method and log-rank test were used to compare the survival rates of patients in different groups. Cox regression models were developed to assess the predictive value of potential predictors for patients' clinical outcomes.
Results: A total of 495 patients with MC were included in this study, and Multivariate analysis revealed that AJCC stage III+IV (HR=2.514, 95%CI: 1.796-3.519, P<0.001), positive tumor deposition (HR=1.723, 95%CI: 1.187-2.499, P=0.004), undergoing surgical treatment (HR=0.16, 95%CI: 0.065-0.393, P<0.001) and receiving chemotherapy (HR=2.328, 95%CI: 1.538-3.523, P<0.001) were potential independent risk factors on OS in MC patients. In addition, the OS and CSS of MC patients were significantly better than those of NEC patients before and after PSM matching (P<0.05); and the OS of MC patients was also better than that of CRC-NET patients before PSM matching (P<0.05), while the OS of MC patients was not significantly different from that of CRC-NET patients after PSM matching (P>0.05).
Conclusion: MC has unique clinicopathological features and its prognosis is better than that of CRC-NET and CRC-NEC.