bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Authors: Fields Madeline C. , Eka Onome , Schreckinger Cristina , Dugan Patricia , Asaad Wael F. , Blum Andrew S. , Bullinger Katie , Willie Jon T. , Burdette David E. , Anderson Christopher , Quraishi Imran H. , Gerrard Jason , Singh Anuradha , Lee Kyusang , Yoo Ji Yeoun , Ghatan Saadi , Panov Fedor , Marcuse Lara V. 
Published: September 2023

IntroductionFor drug resistant epilepsy patients who are either not candidates for resective surgery or have already failed resective surgery, neuromodulation is a promising option. Neuromodulatory approaches include responsive neurostimulation (RNS), deep brain stimulation (DBS), and vagal nerve stimulation (VNS). Thalamocortical circuits are involved in both generalized and focal onset seizures. This paper explores the use of RNS in the centromedian nucleus of the thalamus (CMN) and in the anterior thalamic nucleus (ANT) of patients with drug resistant epilepsy.MethodsThis is a retrospective multicenter study from seven different epilepsy centers in the United States. Patients that had unilateral or bilateral thalamic RNS leads implanted in the CMN or ANT for at least 6 months were included. Primary objectives were to describe the implant location and determine changes in the frequency of disabling seizures at 6 months, 1 year, 2 years, and &gt; 2 years. Secondary objectives included documenting seizure free periods, anti-seizure medication regimen changes, stimulation side effects, and serious adverse events. In addition, the global clinical impression scale was completed.ResultsTwelve patients had at least one lead placed in the CMN, and 13 had at least one lead placed in the ANT. The median baseline seizure frequency was 15 per month. Overall, the median seizure reduction was 33% at 6 months, 55% at 1 year, 65% at 2 years, and 74% at &gt;2 years. Seizure free intervals of at least 3 months occurred in nine patients. Most patients (60%, 15/25) did not have a change in anti-seizure medications post RNS placement. Two serious adverse events were recorded, one related to RNS implantation. Lastly, overall functioning seemed to improve with 88% showing improvement on the global clinical impression scale.DiscussionMeaningful seizure reduction was observed in patients who suffer from drug resistant epilepsy with unilateral or bilateral RNS in either the ANT or CMN of the thalamus. Most patients remained on their pre-operative anti-seizure medication regimen. The device was well tolerated with few side effects. There were rare serious adverse events. Most patients showed an improvement in global clinical impression scores.
Case Report: Response to ipilimumab and nivolumab in a patient with adrenocortical carcinoma
Authors: Charles Rebecca , Madhu Divine , Powles Alexander , Boyde Adam , Hughes Owen , Kumar Nagappan , Moorcraft Sing Yu 
Published: September 2023

BackgroundAdrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options. The evidence for the use of immunotherapy in ACC has been conflicting, with overall response rates ranging from 6 – 33%.Case presentationWe describe the case of a 32 year old patient who was initially thought to have an inoperable clear cell renal cell carcinoma and was treated with immunotherapy with ipilimumab and nivolumab. The patient had an excellent partial response to treatment. Further work-up prior to consideration of surgery demonstrated that the tumour was an ACC, rather than a renal cancer. She had a right adrenalectomy and right hepatectomy, achieving an R0 resection and remains disease-free one year after surgery.ConclusionThis case illustrates the challenge of diagnosing ACC, and that doublet immunotherapy with ipilimumab and nivolumab can have significant clinical efficacy in ACC.
Effect of adjuvants on physicochemical properties of lime sulfur on flower/paraffin and application on flower thinning
Authors: Li Yuanyuan , Liu Yang , Wu Changjie , Zhao Rui , Li Minghua , Cai Jing , Ma Li , He Xiongkui , Wu Xuemin , Zhenhua Zhang 
Published: September 2023

IntroductionAdjuvants can effectively enhance the utilization rate of pesticides, but the application of adjuvants in plant growth regulators is rarely studied.MethodsThis work explored the effects of adjuvants dioctyl sulfosuccinate sodium salt (AOT) and methyl oleate (MO) on lime sulfur (LS), especially the drop behavior on flower and paraffin surface.ResultsThe results showed that the addition of AOT and AOT+MO can significantly reduce the static and dynamic surface tension of LS from 72mN/m to 28mN/m and 32mN/m respectively, and increase the spreading factor from 0.18 to 1.83 and 3.10 respectively, reduce the bounce factor from 2.72 to 0.37 and 0.27 respectively. The fluorescence tracer test showed that the addition of adjuvants could promote the spreading and permeation of droplets. The field test results revealed that the flower thinning rate of adjuvant and non-adjuvant were 80.55% and 54.4% respectively, and the flower thinning effect of adding adjuvant was the same as that of artificial which the flower thinning rate was 84.77%. The quality of apples treated with adjuvants was similar to that treated with artificial, and the weight of single fruit increased by 24.08% compared with CK (spray water).DiscussionThe application of tank-mixture adjuvant could reduce the dosage of LS for thinning agent application, improve apple’s quality, and decrease labor cost and improve the economic benefits of fruit planting and the environmental benefits of plant growth regulators.
The first Portuguese Open Dialogue pilot project intervention
Authors: Tavares Sofia , Ribeiro Joana , Graça Sofia , Araújo Bruna , Puchivailo Mariana , Pereira João G. 
Published: September 2023

IntroductionIn 2020, the Directorate General of Health (DGS), a central service of the Ministry of Health in Portugal, approved and co-financed the first Open Dialogue program in the country. The present report aims to demonstrate the preliminary results of the first year of the project, implemented in the northern interior region of Alentejo.MethodsSeven people at the Center of Concern (PCC) and 21 family members/social networks received care through Open Dialogue; four external social workers and psychologists were also involved in the project as members of the support network. A total of 160 network meetings were undertaken, reaching as many as 27 per month in the busiest periods. Based on a previous Italian Research Protocol, developed by Pocobello et al. (non-published manuscript), quantitative and qualitative data were collected in and after the clinical meetings involving PCC and their family/social network, through a multi-method approach: clinical history interview (e.g., generic research on sociodemographic data, duration of untreated symptoms, reasons for requesting help, possible hospitalizations, and/or treatments/therapies) and the following scales applied every five sessions (e.g., CORE-OM, BSI, GAF, and LSNS-6).ResultsThe preliminary results indicate an improvement in global functioning and the enlargement of social network size/support, a decrease in symptoms, and a negative correlation between the number of sessions and the LSNS6. Medication use remained largely unchanged at the end of the project.DiscussionIn general, even with a small sample, the results are considered satisfactory and seem to be aligned with the vast majority of Open Dialogue studies, which for several decades have consistently pointed toward better recovery rates than treatment as usual as well as increased client satisfaction. We expect that the results presented can boost further research and help strengthen the OD approach.
Analyzing Chinese parents' and teachers' perception of play, children's emotional needs and therapy: implications for seeking help
Authors: Cao Huiting 
Published: September 2023

IntroductionBefore going through play therapy with children, parents' consent is usually needed. Thus, Parents' perception of play therapy can be a very important variable that influences the extent to which children are exposed to play therapy. Previous research has demonstrated the significant influence of social-cultural factors on people's perceptions of play therapy. This may in turn influence parents' decision about whether their children will participate in play therapy. This study explores the factors that influence Chinese parents' decisions on their children's engagement in play therapy from a social-cultural perspective.MethodsThis small-scale research includes the following: a questionnaire with 16 parents; three one-to-one semi-structured interviews with three parents; and one focus group with 3 teachers.ResultsThe results showed that Chinese parents' perceptions of therapy are mostly negative, which may reduce the desire of parents to let their children become involved with play therapy. The children's academic stress and the parents' economic pressures indicate a barrier for families to commit time and money to play therapy. Parents' confidence in their ability to recognize children's emotions, their lack of knowledge about play therapy, and the process of obtaining help from mental health services for children could be another barriers preventing engagement with play therapy.DiscussionsEven though the research is conducted with a very limited sample size and the results cannot represent the wider population, this research provides some insights into this issue that can be explored in detail in future research, to re-evaluate the results and form a more concrete theory within a wider population in China.
A Comprehensive Analysis of Adaptive Image Restoration Techniques in the Presence of Different Noise Models
Authors: Khan Adnan , Alam Imtiaz , Khan Muhammad Fawad , Ahmed Ibtihaj , Islam Zain Ul , Azam Muhammad , Akhtar Awais 
Published: September 2023

Any deprivation caused in the image signal can be thought as a noise. When any image signal is routed through wireless or wired medium it experiences deterioration because of channel characteristics. By knowing the type of noise interfered in the signal, we can use the pertinent filtering techniques to remove the noise from the image. Restoration of the image signal corrupted by noise is very essential for better communication. This paper provides the digital image handling techniques in MATLAB to restore the corrupted image. In this paper, different filtering methods have been discussed in the presence of two separate noise models that distort images. Four different techniques of filtering, ‘Mean/Average filtering', 'Median filtering', 'Adaptive median filtering' and 'Image Averaging' have been chosen against selected noise models. At the end of the paper we will compare which filtering technique works best for removing a particular noise.
Numerical Analysis of Bioinspired Tails in a Fixed-Wing Micro Air Vehicle
Authors: Barroso Barderas Estela , Bardera Mora Rafael , Rodriguez-Sevillano Ángel Antonio , Matías García Juan Carlos 
Published: September 2023

Bird tails play a key role in aerodynamics and flight stability. They produce extra lift for takeoff and landing maneuvers, enhance wing functions and maintain stability during flight (keeping the bird from yawing, rolling and pitching, or otherwise losing control). This paper investigates the use of bioinspired horizontal stabilizers for Micro Air Vehicles (MAVs) involving a Zimmerman wing-body geometry. A selection of five tail shapes of the main types existing in nature is presented, and a parametric analysis is conducted looking into the influence of the most relevant tail geometric parameters to increase the longitudinal static stability of the vehicle. Based on the parametric study, a smaller subset of candidate tail designs are shortlisted to perform a detailed aerodynamic analysis. Then, steady RANS CFD simulations are conducted for a higher-fidelity study of these candidate tail designs to obtain an optimum of each tail type. The criterion for selection of the optimum tail configuration is the maximum aerodynamic efficiency, CLCD , as well as a high longitudinal static stability. The squared-fan tail provides the highest aerodynamic efficiency while maintaining a high longitudinal stability of the vehicle. In conclusion, this paper provides an innovative study of improving longitudinal stability and aerodynamics through the implementation of bioinspired horizontal stabilizers in vehicles with these characteristics.
Tree Species Affect Beetle Diversity on the Common Deciduous Dead Wood in Lithuanian Unmanaged Forests
Authors: Lekoveckaitė Aistė , Jimenez Maria Fernanda Torres , Trakimas Giedrius , Ferenca Romas , Podėnienė Virginija 
Published: September 2023

Beetles living in dead wood are species-specific, suggesting that beetle diversity may vary between different deciduous tree species. However, the patterns of diversity variation among deciduous trees are still poorly understood. In this study, we investigated the diversity of beetles associated with dead wood in the second decay stage in four protected areas of Lithuania, using trunk-emergence traps on Alnus glutinosa L., Gaertn. (black alder), Betula sp. L. (birch), Fraxinus excelsior L. (European ash), Populus tremula L. (European aspen), Quercus robur L. (common oak), and Tilia cordata Mill. (small-leaved linden). The findings of our study indicated variation in beetle diversity among the six tree species examined. We identified the greatest diversity of beetles in the decaying trunks of Quercus robur, followed by T. cordata, and F. excelsior. Our cluster analysis suggested a higher similarity in beetle diversity among tree species sharing the same type of bark; however, our db-RDA analysis showed that tree species explained more variance in the data than bark type. Our results support previous research highlighting the importance of dead wood species diversity in maintaining the diversity of beetles in forests. Within the context of current biodiversity decline, understanding the similarities or differences in beetle communities between tree species is key to tackling the loss of insect species.
Expanding the Microcolonial Black Fungi Aeminiaceae Family: Saxispiralis lemnorum gen. et sp. nov. (Mycosphaerellales), Isolated from Deteriorated Limestone in the Lemos Pantheon, Portugal
Authors: Paiva Diana S. , Trovão João , Fernandes Luís , Mesquita Nuno , Tiago Igor , Portugal António 
Published: September 2023

With an impressive ability to survive in harsh environments, black fungi are an ecological group of melanized fungi that are widely recognized as a major contributor to the biodeterioration of stone cultural heritage materials. As part of the ongoing efforts to study the fungal diversity thriving in a deteriorated limestone funerary art piece at the Lemos Pantheon, a national monument located in Águeda, Portugal, two isolates of an unknown microcolonial black fungus were retrieved. These isolates were thoroughly studied through a comprehensive analysis based on a multi-locus phylogeny of a combined dataset of ITS rDNA, LSU, and rpb2, along with morphological, physiological, and ecological characteristics. Based on the data obtained from this integrative analysis, we propose a new genus, Saxispiralis gen. nov., and a new species, Saxispiralis lemnorum sp. nov., in the recently described Aeminiaceae family (order Mycosphaerellales). Prior to this discovery, this family only had one known genus and species, Aeminium ludgeri, also isolated from deteriorated limestone. Additionally, considering the isolation source of the fungus and to better understand its potential contribution to the overall stone monument biodeterioration, its in vitro biodeteriorative potential was also evaluated. This work represents a significant contribution to the understanding of the fungal diversity involved in the biodeterioration of limestone heritage.
PENGARUH FAKTOR LINGKUNGAN FISIK RUMAH DENGAN KEJADIAN PNEUMONIA BALITA
Authors: Laliyanto Laliyanto , Nurjazuli Nurjazuli , Suhartono Suhartono 
Published: September 2023

Pneumonia adalah penyakit infeksi paru menular secara umum tersebar luas dan menyebabkan peradangan, yang dapat menyebabkan berkurangnya oksigenasi, sesak napas, dan kematian. Indonesia pneumonia masih menjadi permasalahan kesehatan. Prevalensi pneumonia Kabupaten Sleman sebesar 2,47%. Tujuan dari penelitian adalah diketahuinya assosiasi dan besaran risiko antara faktor lingkungan fisik rumah seperti suhu dan kelembapan dalam kamar balita dengan terjadinya pneumonia bayi lima tahun. Metode penelitian adalah analitik observasional dengan pendekatan Cross Sectional survey. Sampel dalam penelitian ini berjumlah 100 balita dengan rentang usia 0-59 bulan. Sampel diambil menggunakan teknik Simple Random Sampling. Variabel yang diteliti pada penelitian ini variabel suhu dan kelembapan yang dihubungkan terhadap pneumonia balita. Hasil penelitian diketahui ada assosiasi antara variabel suhu dengan pneumonia balita p 0,04 dan PR (95%CI) 3,00 (1,11 - 8,07). Hasil pengukuran pada 100 responden tidak ada kamar balita yang kelembapannya memenuhi syarat. Hasil rata-rata kelembapan adalah 76,02%Rh. Ada hubungan signifikan antara suhu dalam kamar balita dengan kejadian penyakit pneumonia balita. Kelembapan pada seluruh kamar balita tidak ada yang memenuhi syarat kesehatan dengan rata-rata kelembapan 76,02%Rh. Membuka ventilasi sebaiknya dilakukan secara berkala supaya terjadi sirkulasi udara sehingga suhu dan kelembapan dalam kamar balita dapat memenuhi syarat kesehatan.
Un anniversaire : l'introduction du terme de comportement (1908)
Authors: Piéron Henri 
Published: September 2023

Des expériences concernant la perception des mimiques ont été effectuées sur plusieurs groupes d’enfants d’âge scolaire, de milieux économiques et sociaux différents. Les épreuves consistaient en des classements simples d’images où des critères mimiques et des critères «accessoires» (chapeau, boucles d’oreilles) étaient mis en concurrence. Les résultats ont fait ressortir un renversement de la hiérarchie de ces critères dans les sélections des enfants, les critères «accessoires» étant prédominants avant 9-10 ans, les critères mimiques devenant prédominants chez les enfants plus âgés (ainsi que chez les adultes). Ce renversement est plus précoce dans les groupes d’enfants de milieux aisés que dans ceux de milieux économiquement défavorisés.
On a discuté les relations possibles de ce phénomène d’émergence des mimiques avec l’évolution génétique de l’attitude sociale de l’enfant (processus de socialisation), avec son attitude mentale (évolution de sa pensée), et plus particulièrement avec les modalités de l’utilisation du langage suivant les âges.
Genèse de l'acte graphique
Authors: Lurçat Liliane 
Published: September 2023

Les premiers modèles reproduits par l’enfant au cours de la genèse de l’acte graphique sont des modèles fonctionnels, ils naissent de l’activité graphique spontanée. C’est dans le perfectionnement de cette activité que convergent les différents contrôles kinesthésiques et visuels permettant la réalisation et la reproduction de formes géométriquement simples.
Progressivement, le système constitué par la main et l’œil permet la reproduction de modèles perçus visuellement, ou bien représentés. La convergence temporelle des contrôles kinesthésiques et visuels, puis la précession de la vue sur la kinesthésie paraissent constituer un facteur important dans la réalisation des modèles visuels.
Avaliação de competências do enfermeiro hospitalar como subsídio para o cotidiano da educação permanente
Authors: Garbelini Maria Cecilia Da Lozzo , Dias Cristiane Pavelski , Ribeiro Elaine Rossi 
Published: September 2023

RESUMO

As competências dos enfermeiros são concebidas como um conjunto dos seus conhecimentos, habilidades e atitudes para exercer com eficácia suas funções. Objetivou-se, neste estudo, identificar as competências dos enfermeiros no gerenciamento de seis dimensões, em contexto hospitalar. Trata-se de um estudo exploratório descritivo com abordagem quantitativa realizado com 28 enfermeiros. A coleta de dados foi realizada pela aplicação de um instrumento relativo aos dados sociodemográficos e pela Escala de Avaliação de Competência do Enfermeiro, construída e validada por Bernardina (2019). Como resultado os enfermeiros se autoavaliaram como competentes em relação às ações na prática de trabalho, ou seja, quanto às dimensões de trabalho técnico e em equipe, bem como no gerenciamento de recursos humanos. Somente a dimensão gerenciamento de recursos materiais apontou para uma lacuna de um item de conhecimento, o que indica a possibilidade de desenvolvimento de estratégias pedagógicas na perspectiva responder as necessidades da organização hospitalar neste quesito. Considera-se a avaliação por competências é um tema que merece atenção, pois tem impactos no gerenciamento da assistência e do cuidado, assim como em funções administrativas, com consequente melhoria dos indicadores de saúde.
Palavras chave: Equipe de Enfermagem. Hospital. Competência profissional.
La Orquesta Sinfónica de Vientos de Boyacá 2001-2005: Reconstrucción histórica y perspectiva de los intérpretes
Authors: Velásquez Merchán Karen Viviana , Cárdenas Soler Ruth Nayibe , Gutiérrez Torres Adriana Marien , Palencia Dotor Rosa María 
Published: September 2023

El artículo presenta los resultados de investigación del proyecto La Orquesta Sinfónica de Vientos de Boyacá 2001-2005: Reconstrucción histórica y perspectiva de los intérpretes. A través de un análisis documental a los archivos del ensamble, archivos personales de exintegrantes de la orquesta y programas de mano se consolidó parte de la memoria histórica del último período de trabajo de la única orquesta formato sinfónico de carácter profesional que ha tenido el departamento de Boyacá. Además, se realizaron entrevistas a músicos del ensamble para, sumado a la información documental recabada, reconstruir los últimos años de funcionamiento del ensamble boyacense.
Se concluye que el período de cierre estuvo marcado por entramados normativos y burocráticos que se tejieron gracias a la ley 617 de 2000 y fue ejecutado por voluntades políticas durante el gobierno de Álvaro Uribe Vélez. Además, los integrantes y personal logístico correspondían a jerarquías y formas de contratación propias de categoría profesional. Así mismo, el repertorio vinculó obras de compositores universales, latinoamericanos y colombianos, con mayor sesgo hacia las músicas centroeuropeas.
Narrativas exiliares en la contemporaneidad de las dictaduras de la Doctrina de la Seguridad Nacional en el Cono Sur de América Latina
Authors: Jensen Silvina 
Published: September 2023

Este artículo se propone incidir en una coyuntura que identifico como fundacional para la articulación y/o visibilización de narrativas identitarias sobre la experiencia de expatriación política. Y postula que más allá de las singularidades de los procesos exiliares brasileño, uruguayo, chileno y argentino, entre finales de los años 1970 y principios de los 1980, los perseguidos de todas las dictaduras del Cono Sur protagonizaron una común empresa de toma de consciencia del estado de exilio.
Atento a las posibilidades hermenéuticas de la Historia Conectada, el trabajo construye algunas hipótesis acerca de la urgencia, interés y preocupación de explicar(se) el exilio que pareció afectar al mismo tiempo a huidos y expulsados de todas las dictaduras de la Doctrina de la Seguridad Nacional, quienes con propósitos diversos y construyendo interlocuciones singulares (los propios compañeros de la diáspora, la comunidad internacional, sus connacionales que no habían salido al exilio) convergieron en la tarea de dar sentido a una experiencia a la que comenzaban a tipificar como inédita, tanto por su masividad como por su carácter violento en la región.