bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the cosmological arrow of time
Authors: Henriksson Andreas 
Published: April 2023

The cosmological arrow of time is defined by the initial conditions of the Universe and its subsequent expansion. Wetterich [1] has proposed an alternative picture of the expanding Universe where the observed cosmological redshift can equivalently be viewed as originating from the increase in mass of particles over time. In this article, we address the following problem: How can the cosmological arrow of time be interpreted in a static Universe where the particle masses increase? We take the philosophical point of view that the set of minima in the effective potential of a symmetry-broken quantum field theory represents physically coexisting groundstates. Tunneling of energy, carried by instantons, within the set of groundstates, is suggested to induce the change in particle masses. The directionality in which the instanton energy tends to flow, i.e. from high-energy-density to low-energy-density groundstates, defines then the cosmological arrow of time. It is concluded that the premises on which this article is built, i.e. the philosophical assumption that the set of groundstates physically coexists, is invalid if it is found to be impossible to provide a sound argument for the increase in entropy within a contracting spacetime. This is because otherwise the second law of thermodynamics is violated.
PENGARUH WOM, PERSEPSI KEMUDAHAN, DAN PERSEPSI RESIKO TERHADAP MINAT BELANJA KONSUMEN PADA BUKALAPAK
Authors: Sitompul Yeni Opita , Siharis Alkadri Kusalendra 
Published: April 2023

This study aims to determine the effect of word of mouth, perceived convenience and risk perception on consumer spending interest in the Bukalapak application. The population of the object in this study is the residents of Janjinauli Village, amounting to approximately 800 people. The sampling technique was carried out by the random sampling method. Data analysis used in this study is by conducting interviews, observations, and literature studies. The results of this study indicate that word of mouth with an average weight of 78% perceived ease with an average weight of 80% of perceived risk on average. a weight of 85% can influence and attract consumer buying interest on the Bukalapak online shopping site.
Keywords:Bukalapak 1, interest in online shopping 2,perceived convenience 3,risk perception 4,word of mouth
PENGARUH MODAL INTELEKTUAL TERHADAP KEUNGGULAN KOMPETITIF BERKELANJUTAN KSP DI KOTA KUPANG
Authors: Zacharias Jems Arison 
Published: April 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh dari modal intelektual terhadap Keunggulan Kompetitif Berkelanjutan Koperasi Simpan Pinjam (KSP) di Kota Kupang. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survey. Hasil Penelitian menunjukkan bahwa dari 3 komponen Modal Intelektual, hanya Structural Capital yang berpengaruh terhadap Keunggulan Kompetitif Berkelanjutan. Sedangkan Human Capital dan Relational Capital tidak berpengaruh terhadap Keunggulan Kompetitif Berkelanjutan. Penelitian ini dapat menjadi acuan bagi para pengambil keputusan dalam pengembangan keunggulan kompetitif berkelanjutan KSP di Kota Kupang melalui modal intelektualnya.
RELATIONSHIP OF KNOWLEDGE AND ATTITUDE TOWARDS FLOOD DISASTER PREPAREDNESS IN SUKU TIGA VILLAGE NASAL DISTRICT KAUR REGENCY
Authors: Listiana Devi , Sari Gita Maya , Colin Vellyza , Abdillah Muhammad Adithya 
Published: April 2023

Flood disasters not only cause casualties but can also cause problems in the health sector. This study aims to study the relationship of knowledge and attitudes towards flood disaster preparedness in Suku Tiga Village of Nasal District, Kaur Regency. This research uses quantitative descriptive methods using analytical observational methods, namely cross-sectional studies. The population in this study is the entire community in Suku Tiga Village of Nasal District Kaur Regency, which amounts to 760 people. The sampling technique used is a simple random sampling technique using the Slovin formula, which amounts to 88 people. This study used primary data obtained from respondents using questionnaires. Data analysis was carried out univariately and bivariately. The results of the study were ob-tained Spearman's rho test results were obtained by 0.298 with p-value = 0.005 < 0.05 significant, meaning that there was a relationship between knowledge and flood disaster preparedness in Suku Tiga Village of Nasal District, Kaur Regency. Because the rho value is located in the interval 0.20 – 0.40 then the category of medium relationship. Spearman's rho test re-sults were obtained by 0.129 with p-value = 0.230> 0.05 was insignificant, meaning that there was no significant relationship between respondents' attitudes and flood preparedness in Suku Tiga Village of Nasal District, Kaur Regency. There is a relationship between knowledge and flood disaster preparedness in Suku Tiga Village of Nasal District, Kaur Regen-cy with the category of medium relationship. There is no relationship be-tween attitude and flood disaster preparedness in Suku Tiga Village of Nasal District, Kaur Regency. It is hoped that nurses will be able to pro-vide training to the community on disaster response so that they can in-crease knowledge and shape community attitudes so that they can improve preparedness in facing flood disasters.
The involvement of ADAR1 in chronic unpredictable stress-induced cognitive impairment by targeting DARPP-32 with miR-874-3p in BALB/c mice
Authors: Wang Yanfang , Liu Yingxin , Zhao Ziwei , Wu Xinyu , Lin Jiabin , Li Yufei , Yan Wei , Wu Yi , Shi Yanfei , Wu Xindi , Xue Ying , He Jiaqian , Liu Shuqi , Zhang Xiaonan , Xu Hong , Tang Yiyuan , Yin Shengming 
Published: April 2023

Introduction: Chronic stress exposure is the main environmental factor leading to cognitive impairment, but the detailed molecular mechanism is still unclear. Adenosine Deaminase acting on double-stranded RNA1(ADAR1) is involved in the occurrence of chronic stress-induced cognitive impairment. In addition, dopamine and Adenosine 3′5′-monophosphate-regulated phospho-protein (DARPP-32) gene variation affects cognitive function. Therefore, we hypothesized that ADAR1 plays a key role in chronic stress-induced cognitive impairment by acting on DARPP-32.Methods: In this study, postnatal 21-day-old male BALB/c mice were exposed to chronic unpredictable stressors. After that, the mice were treated with ADAR1 inducer/inhibitor. The cognitive ability and cerebral DARPP-32 protein expression of BALB/c mice were evaluated. In order to explore the link between ADAR1 and DARPP-32, the effects of ADAR1 high/low expression on DARPP-32 protein expression in vitro were detected.Results: ADAR1 inducer alleviates cognitive impairment and recovers decreased DARPP-32 protein expression of the hippocampus and prefrontal cortex in BALB/c mice with chronic unpredictable stress exposure. In vivo and in vitro studies confirm the results predicted by bio-informatics; that is, ADAR1 affects DARPP-32 expression via miR-874-3p.Discussion: The results in this study demonstrate that ADAR1 affects the expression of DARPP-32 via miR-874-3p, which is involved in the molecular mechanism of pathogenesis in chronic unpredictable stress-induced cognitive impairment. The new findings of this study provide a new therapeutic strategy for the prevention and treatment of stress cognitive impairment from epigenetics.
Organic–inorganic hybrid salt and mixed ligand Cr(III) complexes containing the natural flavonoid chrysin: Synthesis, characterization, computational, and biological studies
Authors: Alem Mamaru Bitew , Desalegn Tegene , Damena Tadewos , Bayle Enyew Alemayehu , Koobotse Moses O. , Ngwira Kennedy J. , Ombito Japheth O. , Zachariah Matshediso , Demissie Taye B. 
Published: April 2023

Organic–inorganic hybrid salt and mixed ligand Cr(III) complexes (Cr1 and Cr2) containing the natural flavonoid chrysin were synthesized. The metal complexes were characterized using UV-Vis, Fourier-transform infrared, MS, SEM-EDX, XRD, and molar conductance measurements. Based on experimental and DFT/TD-DFT calculations, octahedral geometries for the synthesized complexes were suggested. The powder XRD analysis confirms that the synthesized complexes were polycrystalline, with orthorhombic and monoclinic crystal systems having average crystallite sizes of 21.453 and 19.600 nm, percent crystallinities of 51% and 31.37%, and dislocation densities of 2.324 × 10−3 and 2.603 × 10−3 nm-2 for Cr1 and Cr2, respectively. The complexes were subjected to cytotoxicity, antibacterial, and antioxidant studies. The in vitro biological studies were supported with quantum chemical and molecular docking computational studies. Cr1 showed significant cytotoxicity to the MCF-7 cell line, with an IC50 value of 8.08 μM compared to 30.85 μM for Cr2 and 18.62 μM for cisplatin. Cr2 showed better antibacterial activity than Cr1. The higher EHOMO (−5.959 eV) and dipole moment (10.838 Debye) values of Cr2 obtained from the quantum chemical calculations support the observed in vitro antibacterial activities. The overall results indicated that Cr1 is a promising cytotoxic drug candidate.
Bibliometric and visualized analysis of elite controllers based on CiteSpace: landscapes, hotspots, and frontiers
Authors: Yuan Xingyue , Lai Yu 
Published: April 2023

BackgroundA unique subset of people living with HIV, known as elite controllers, possess spontaneous and consistent control over viral replication and disease progression in the absence of antiviral intervention. In-depth research on elite controllers is conducive to designing better treatment strategies for HIV. However, comprehensive and illuminating bibliometric reports on elite controllers are rare.MethodsArticles on elite controllers were retrieved from the Web of Science Core Collection. A visualized analysis of this domain was conducted by CiteSpace software. Taking count, betweenness centrality, and burst value as criteria, we interpreted the visualization results and predicted future new directions and emerging trends.ResultsBy December 31, 2022, 843 articles related to elite controllers had been published. The largest contributors in terms of country, institution, and author were the United States (485), Univ Calif San Francisco (87), and Walker B.D. (65), respectively. Migueles S.A. (325) and Journal of Virology (770) were the most cocited author and journal, respectively. Additionally, by summarizing the results of our CiteSpace software analysis on references and keywords, we considered that the research hotspots and frontiers on elite controllers mainly focus on three aspects: deciphering the mechanisms of durable control, delineating the implications for the development of treatments for HIV infection, and highlighting the clinical risks faced by elite controllers and coping strategies.ConclusionThis study performed a bibliometric and visual analysis of elite controllers, identified the main characteristics and emerging trends, and provided insightful references for further development of this rapidly evolving and complex field.
Myocardial deformation in malignant mitral valve prolapse: A shifting paradigm to dynamic mitral valve–ventricular interactions
Authors: Pace Nathalie , Sellal Jean-Marc , Venner Clement , Mandry Damien , Marie Pierre-Yves , Filippetti Laura , Echivard Mathieu , Fraix Antoine , Girerd Nicolas , Lamiral Zohra , De Chillou Christian , Sadoul Nicolas , Selton-Suty Christine , Huttin Olivier 
Published: April 2023

ObjectivesThis study sought to assess the value of myocardial deformation using strain echocardiography in patients with mitral valve prolapse (MVP) and severe ventricular arrhythmia and to evaluate its impact on rhythmic risk stratification.BackgroundMVP is a common valvular affection with an overly benign course. Unpredictably, selected patients will present severe ventricular arrhythmia.MethodsPatients with MVP as the only cause of aborted SCD (MVP-aSCD: ventricular fibrillation and monomorphic and polymorphic ventricular tachycardia) with no other obvious reversible cause were identified. Nonconsecutive patients referred for the echocardiographic evaluation of MVP were enrolled as a control cohort and dichotomized according to the presence or absence of premature ventricular contractions (MVP-PVC or MVP-No PVC, respectively). All patients had a comprehensive strain assessment of mechanical dispersion (MD), postsystolic shortening, and postsystolic index (PSI).ResultsA total of 260 patients were enrolled (20 MVP-aSCD, 54 MVP-PVC, and 186 MVP-No PVC). Deformation pattern discrepancies were observed with a higher PSI value in MVP-aSCD than that in MVP-PVC (4.6 ± 2.0 vs. 2.9 ± 3.7, p = 0.014) and a higher MD value than that in MVP-No PVC (46.0 ± 13.0 vs. 36.4 ± 10.8, p = 0.002). In addition, PSI and MD increased the prediction of severe ventricular arrhythmia on top of classical risk factors in MVP. Net reclassification improvement was 61% (p = 0.008) for PSI and 71% (p = 0.001) for MD.ConclusionsIn MVP, myocardial deformation analysis with strain echocardiography identified specific contraction patterns with postsystolic shortening leading to increased values of PSI and MD, translating the importance of mitral valve–myocardial interactions in the arrhythmogenesis of severe ventricular arrhythmia. Strain echocardiography may provide important implications for rhythmic risk stratification in MVP.
Clinical outcomes of a CT protocol for simultaneous examination of the aorta and coronary artery in patients with aortic aneurysm
Authors: Kim Hoyoung , Kim Jihoon , Choe Yeon Hyeon , Kim Sung Mok 
Published: April 2023

ObjectivesIn patients with aortic aneurysm (AA), coronary artery disease (CAD) increases the risk of perioperative complications and even asymptomatic CAD is associated with adverse clinical outcomes. We aimed to compare coronary-aorta CT (CACT) with thoracoabdominal CT angiography (Aorta CT) for CAD management and clinical outcomes in these patients.MethodsWe enrolled 479 patients undergoing CACT and 693 patients undergoing Aorta CT as an initial CT scan for AA. The primary outcome was a composite of all-cause death or myocardial infarction (MI) at 3 years after CT. The secondary outcomes were subsequent CAD management and invasive coronary angiography (CAG).ResultsAfter index CT scan, the CACT group had a significantly higher rate of coronary revascularization compared with the Aorta CT group (10.7% vs. 3.8%, p &lt; 0.001) but a lower probability of diagnostic CAG among total invasive CAG (32% vs. 55%, p &lt; 0.001). At 3 months after the CT scan, the prescription rates of statins (65.8% vs. 44.6%, p &lt; 0.001) and antiplatelet agents (57.6% vs. 43.9%, p &lt; 0.001) were higher in the CACT group. During follow-up, the CACT group had a significantly lower incidence of the composite outcome of all-cause death or MI (adjusted HR 1.72, 95% CI 1.07–2.78, p = 0.027) than the Aorta CT group.ConclusionAmong patients with AA, CACT was associated with a higher rate of subsequent CAD management and a lower risk of all-cause death or MI compared to Aorta CT. When evaluating with AA using CT, simultaneous coronary and aortic evaluation using CACT would be recommended over Aorta CT.
Executive functions and classroom behaviour in second graders
Authors: Heemskerk Christina Hubertina Helena Maria , Roebers Claudia M. 
Published: April 2023

BackgroundExecutive functions along with on-task behaviour in the classroom relate to academic success. Examining the shared and non-shared variances in their relationships with academic achievement may lead to a better understanding of the contribution of executive functions to achievement and may uncover a mechanism to explain why they are so important for school success. Specifically, we investigated the extent to which executive functions and classroom behaviour offer different and similar perspectives on children’s self-regulatory behaviour, and make unique contributions to academic achievement.MethodData were collected from 129 2nd grade students (M age = 7.93 years, SD = 0.5; 44.2% female). Participants were observed for 25 min during a ‘business-as-usual’ classroom lesson, following a momentary assessment protocol; we developed and used an openly available mobile application. Subsequently, participants completed an executive function task (Hearts and Flowers) in small groups on tablet computers. Teachers rated students’ academic achievement in language and mathematics.ResultsWe found unique contributions for on-task behaviour and executive functions to academic achievement in 2nd grade. Moreover, we found that 27–31% of the total effect of inhibition on language achievement was mediated through on-task behaviour.ConclusionWe have shown that executive functions and on-task behaviour share variance in their relationship to academic achievement, as well as providing a unique perspective on children’s self-regulatory behaviour. Thus, researchers might want consider the inclusion of both executive function tasks and ecologically valid measures such as the current, easy to apply behavioural observation in a naturalistic setting in their future work.
Exploring the reasons why mothers do not breastfeed, to inform and enable better support
Authors: Roberts Dean , Jackson Leanne , Davie Philippa , Zhao Catherine , Harrold Joanne A. , Fallon Victoria , Silverio Sergio A. 
Published: April 2023

IntroductionInfant and maternal breastfeeding benefits are well documented, globally. Despite efforts to increase global breastfeeding rates, the majority of high-income settings fall short of recommended targets. Breastfeeding rates in the UK are especially poor, and physiological difficulties (e.g., inverted nipples), fail to account for the observed breastfeeding intention-behaviour gap.MethodThe current online study sought to investigate the infant feeding experiences of 624 UK formula feeding mothers, through open text survey responses.ResultsA content analysis identified the following clusters of reasons for formula feeding: Feeding Attitudes, Feeding Problems, Mental Health, and Sharing the Load.DiscussionFeeding Attitudes explained a large percentage of reasons given for formula feeding. Recommendations are made to improve antenatal breastfeeding education and to develop an intervention with an aim to improve maternal breastfeeding attitudes and subsequent practice. Feeding Problems also explained a large portion of combination feeding and started but stopped infant feeding accounts. The current paper calls for more comprehensive and tailored antenatal breastfeeding education to refine practical breastfeeding skills necessary for successful breastfeeding establishment and maintenance. Mental Health explained relatively small coverage. Suggestions are therefore made to train mental health practitioners on infant feeding with an aim to provide more extensive support, which may serve to disrupt the bidirectional relationship between poor mental health and poor breastfeeding outcomes. Finally, Sharing the Load explained moderate coverage across never breastfed, combination fed, and started but stopped feeding groups. Recommendations are made, in light of these findings, to tighten workplace legislation to protect breastfeeding women.
Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system
Authors: Ayoub Ikram , Dauvilliers Yves , Barateau Lucie , Vermeulen Thaïs , Mouton-Barbosa Emmanuelle , Marcellin Marlène , Gonzalez-de-Peredo Anne , Gross Catharina C. , Saoudi Abdelhadi , Liblau Roland 
Published: April 2023

IntroductionNarcolepsy type 1 (NT1) is a rare, chronic and disabling neurological disease causing excessive daytime sleepiness and cataplexy. NT1 is characterized pathologically by an almost complete loss of neurons producing the orexin neuropeptides in the lateral hypothalamus. Genetic and environmental factors strongly suggest the involvement of the immune system in the loss of orexin neurons. The cerebrospinal fluid (CSF), secreted locally and surrounding the central nervous system (CNS), represents an accessible window into CNS pathological processes.MethodsTo gain insight into the biological and molecular changes in NT1 patients, we performed a comparative proteomics analysis of the CSF from 21 recent-onset NT1 patients and from two control groups: group 1 with somatoform disorders, and group 2 patients with hypersomnia other than NT1, to control for any potential effect of sleep disturbances on CSF composition. To achieve an optimal proteomic coverage analysis, the twelve most abundant CSF proteins were depleted, and samples were analyzed by nano-flow liquid chromatography tandem mass spectrometry (nano-LC-MS/MS) using the latest generation of hybrid Orbitrap mass spectrometer.Results and discussionOur study allowed the identification and quantification of up to 1943 proteins, providing a remarkably deep analysis of the CSF proteome. Interestingly, gene set enrichment analysis indicated that the complement and coagulation systems were enriched and significantly activated in NT1 patients in both cohorts analyzed. Notably, the lectin and alternative complement pathway as well as the downstream lytic membrane attack complex were congruently increased in NT1. Our data suggest that the complement dysregulation in NT1 patients can contribute to immunopathology either by directly promoting tissue damage or as part of local inflammatory responses. We therefore reveal an altered composition of the CSF proteome in NT1 patients, which points to an ongoing inflammatory process contributed, at least in part, by the complement system.
The influence of high glucose conditions on macrophages and its effect on the autophagy pathway
Authors: Sousa Emanuella S. A. , Queiroz Luiz A. D. , Guimarães João P. T. , Pantoja Kamilla C. , Barros Rafael S. , Epiphanio Sabrina , Martins Joilson O. 
Published: April 2023

IntroductionMacrophages are central cells in mediating the inflammatory response.Objective and MethodsWe evaluated the effect of high glucose conditions on the inflammatory profile and the autophagy pathway in Bone-Marrow Derived Macrophages (BMDM) from diabetic (D-BMDM) (alloxan: 60mg/kg, i.v.) and non-diabetic (ND-BMDM) C57BL/6 mice. BMDM were cultured in medium with normal glucose (5.5 mM), or high glucose (25 mM) concentration and were primed with Nigericin (20µM) stimulated with LPS (100 ng/mL) at times of 30 minutes; 2; 4; 6 and 24 hours, with the measurement of IL-6, IL-1β and TNF-α cytokines.ResultsWe have further identified changes in the secretion of pro-inflammatory cytokines IL-6, IL-1β and TNF-α, where BMDM showed increased secretion of these cytokines after LPS + Nigericin stimulation. In addition, changes were observed in the autophagy pathway, where the increase in the autophagic protein LC3b and Beclin-1 occurred by macrophages of non-diabetic animals in hyperglycemic medium, without LPS stimulation. D-BMDM showed a reduction on the expression of LC3b and Beclin-1, suggesting an impaired autophagic process in these cells.ConclusionThe results suggest that hyperglycemia alters the inflammatory pathways in macrophages stimulated by LPS, playing an important role in the inflammatory response of diabetic individuals.