bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tackling imbalanced data in cybersecurity with transfer learning: a case with ROP payload detection
Authors: Wang Haizhou , Singhal Anoop , Liu Peng 
Published: January 2023

AbstractIn recent years, deep learning gained proliferating popularity in the cybersecurity application domain, since when being compared to traditional machine learning methods, it usually involves less human efforts, produces better results, and provides better generalizability. However, the imbalanced data issue is very common in cybersecurity, which can substantially deteriorate the performance of the deep learning models. This paper introduces a transfer learning based method to tackle the imbalanced data issue in cybersecurity using return-oriented programming payload detection as a case study. We achieved 0.0290 average false positive rate, 0.9705 average F1 score and 0.9521 average detection rate on 3 different target domain programs using 2 different source domain programs, with 0 benign training data sample in the target domain. The performance improvement compared to the baseline is a trade-off between false positive rate and detection rate. Using our approach, the total number of false positives is reduced by 23.16%, and as a trade-off, the number of detected malicious samples decreases by 0.68%.
Assessment of safe injection awareness and practices among healthcare providers at primary health care facilities
Authors: Ali Lamia , Eldessouki Randa 
Published: January 2023

Abstract
Background
Unsafe injection necessitates some preventive steps including promoting and assuring the execution of safe injection administration and waste disposal methods. The present study aimed to assess the awareness and practices of safe injection among health care providers working at all primary health care (PHC) facilities in Fayoum governorate, Egypt. Also, it assessed the awareness, readiness, and response related to needle stick injuries (NSIs).

Methods
A cross-sectional observational study conducted from September to December 2019 at all working PHC facilities in Fayoum Governorate, Egypt, resulted in enrolling 685 health care providers, and observation of 520 injection processes. Data were collected by a combination of staff interviews and structured observation of different injection processes using the WHO revised C tool.

Results
Safe injection and post-exposure NSI policies and procedures was implemented in 96.5% of the PHC facilities. Compliance to hand wash before preparing a procedure was 56.7%. Immediate disposal of used needles was 76.2% in observed injections. Hepatitis B vaccination rate among participants was 87.2%. Most participants 87.6% admitted the existence of a NSI reporting system but only 38.8% of those who had experienced NSI event reported. The rate of NSI was 14%.

Conclusions
Fayoum PHC facilities have good awareness level among providers and broadly accepted compliance with injection practices as per the WHO tool. Most injection-safety aspects were satisfactory, and implemented measures to face NSI were in place. Appropriate timely actions are required to maintain the fair awareness and improve injections practices in the PHC facilities.
The management of newborns with critical congenital heart diseases prior to transport to a cardiac center
Authors: Alkhushi Naif 
Published: January 2023

AbstractCritical congenital heart diseases (CCHD) are important causes of mortality and morbidity in the newborn period. Even after diagnosis, their management could be seriously compromised by the unplanned delivery in hospitals with limited expertise and resources. The newborn may spend days or week before transport putting a significant burden on the neonatal team to manage such challenging diseases. In this review, the management principles of each individual pathology are discussed in the setting before transport to cardiac centers. Understanding these principles will help the treating teams evaluate and manage those complex conditions. The review avoids the advanced discussion on the management of CCHDs not applicable to the pre-transport setup. It highlights the critical elements in the maintenance of normal hemodynamics specific to each pathology and their variation.
Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline
Authors: Shah Manish A. , Kennedy Erin B. , Alarcon-Rozas Ashley E. , Alcindor Thierry , Bartley Angela N. , Malowany Aubrey Belk , Bhadkamkar Nishin A. , Deighton Dana C. , Janjigian Yelena , Karippot Asha , Khan Uqba , King Daniel A. , Klute Kelsey , Lacy Jill , Lee James J. , Mehta Rutika , Mukherjee Sarbajit , Nagarajan Arun , Park Haeseong , Saeed Anwaar , Semrad Thomas J. , Shitara Kohei , Smyth Elizabeth , Uboha Nataliya V. , Vincelli Melani , Wainberg Zev , Rajdev Lakshmi 
Published: January 2023

PURPOSE To develop recommendations involving targeted therapies for patients with advanced gastroesophageal cancer. METHODS The American Society of Clinical Oncology convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice. RESULTS Eighteen randomized controlled trials met the inclusion criteria for the systematic review. RECOMMENDATIONS For human epidermal growth factor receptor 2 (HER2)–negative patients with gastric adenocarcinoma (AC) and programmed death-ligand 1 (PD-L1) combined positive score (CPS) ≥ 5, first-line therapy with nivolumab and chemotherapy (CT) is recommended. For HER2-negative patients with esophageal or gastroesophageal junction (GEJ) AC and PD-L1 CPS ≥ 5, first-line therapy with nivolumab and CT is recommended. First-line therapy with pembrolizumab and CT is recommended for HER2-negative patients with esophageal or GEJ AC and PD-L1 CPS ≥ 10. For patients with esophageal squamous cell carcinoma and PD-L1 tumor proportion score ≥ 1%, nivolumab plus CT, or nivolumab plus ipilimumab is recommended; for patients with esophageal squamous cell carcinoma and PD-L1 CPS ≥ 10, pembrolizumab plus CT is recommended. For patients with HER2-positive gastric or GEJ previously untreated, unresectable or metastatic AC, trastuzumab plus pembrolizumab is recommended, in combination with CT. For patients with advanced gastroesophageal or GEJ AC whose disease has progressed after first-line therapy, ramucirumab plus paclitaxel is recommended. For HER2-positive patients with gastric or GEJ AC who have progressed after first-line therapy, trastuzumab deruxtecan is recommended. In all cases, participation in a clinical trial is recommended as it is the panel's expectation that targeted treatment options for gastroesophageal cancer will continue to evolve. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .
Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation
Authors: Neumann Neil M. , Kim Daniel M. , Huebner Robert J. , Ewald Andrew J. 
Published: January 2023

ABSTRACT
Branched epithelial networks are generated through an iterative process of elongation and bifurcation. We sought to understand bifurcation of the mammary epithelium. To visualize this process, we utilized three-dimensional (3D) organotypic culture and time-lapse confocal microscopy. We tracked cell migration during bifurcation and observed local reductions in cell speed at the nascent bifurcation cleft. This effect was proximity dependent, as individual cells approaching the cleft reduced speed, whereas cells exiting the cleft increased speed. As the cells slow down, they orient both migration and protrusions towards the nascent cleft, while cells in the adjacent branches orient towards the elongating tips. We next tested the hypothesis that TGF-β signaling controls mammary branching by regulating cell migration. We first validated that addition of TGF-β1 (TGFB1) protein increased cleft number, whereas inhibition of TGF-β signaling reduced cleft number. Then, consistent with our hypothesis, we observed that pharmacological inhibition of TGF-β1 signaling acutely decreased epithelial migration speed. Our data suggest a model for mammary epithelial bifurcation in which TGF-β signaling regulates cell migration to determine the local sites of bifurcation and the global pattern of the tubular network.
Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity
Authors: Kumar Abhishek , Waingankar Tejashree Pradip , D'Silva Patrick 
Published: January 2023

ABSTRACT
TIM22 pathway cargos are essential for sustaining mitochondrial homeostasis as an excess of these proteins leads to proteostatic stress and cell death. Yme1 is an inner membrane metalloprotease that regulates protein quality control with chaperone-like and proteolytic activities. Although the mitochondrial translocase and protease machinery are critical for organelle health, their functional association remains unexplored. The present study unravels a novel genetic connection between the TIM22 complex and YME1 machinery in Saccharomyces cerevisiae that is required for maintaining mitochondrial health. Our genetic analyses indicate that impairment in the TIM22 complex rescues the respiratory growth defects of cells without Yme1. Furthermore, Yme1 is essential for the stability of the TIM22 complex and regulates the proteostasis of TIM22 pathway substrates. Moreover, impairment in the TIM22 complex suppressed the mitochondrial structural and functional defects of Yme1-devoid cells. In summary, excessive levels of TIM22 pathway substrates could be one of the reasons for respiratory growth defects of cells lacking Yme1, and compromising the TIM22 complex can compensate for the imbalance in mitochondrial proteostasis caused by the loss of Yme1.
AMG232 inhibits angiogenesis in glioma through the p53–RBM4–VEGFR2 pathway
Authors: Xiao Yao , Li Mingliang , Ma Teng , Ning Hao , Liu Libo 
Published: January 2023

ABSTRACT
AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial cells (GECs) in a dose-dependent manner and inhibits the angiogenesis of GECs. p53 and RNA-binding motif protein 4 (RBM4) were expressed at low levels in GECs, while MDM2 and vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR) were highly expressed. In vitro and in vivo experiments confirmed that AMG232 upregulated p53 and RBM4, and downregulated MDM2 and VEGFR2 by blocking the MDM2–p53 interaction. Both p53 silencing and RBM4 silencing significantly upregulated the expression of VEGFR2, promoted the proliferation, migration and tube formation of GECs, and reversed the effects of AMG232 on downregulating VEGFR2 and inhibiting the angiogenesis of GECs. AMG232 increased RBM4 expression by upregulating p53, and p53 bound to RBM4 and promoted its transcription. RBM4 bound to and shortened the half-life of VEGFR2, promoting its degradation. Finally, AMG232 produced a significant decrease in new vessels and hemoglobin content in vivo. This study proves that AMG232 inhibits glioma angiogenesis by blocking the MDM2–p53 interaction, in which the p53–RBM4–VEGFR2 pathway plays an important role.
Temporal configuration and modality of components determine the performance of bumble bees during the learning of a multimodal signal
Authors: Riveros Andre J. 
Published: January 2023

ABSTRACT
Across communicative systems, the ability of compound signals to enhance receiver's perception and decoding is a potent explanation for the evolution of complexity. In nature, complex signaling involves spatiotemporal variation in perception of signal components; yet, how the synchrony between components affects performance of the receiver is much less understood. In the coevolution of plants and pollinators, bees are a model for understanding how visual and chemical components of floral displays may interact to influence performance. Understanding whether the temporal dimension of signal components impacts performance is central for evaluating hypotheses about the facilitation of information processing and for predicting how particular trait combinations function in nature. Here, I evaluated the role of the temporal dimension by testing the performance of bumble bees under restrained conditions while learning a bimodal (olfactory and visual) stimulus. I trained bumble bees under six different stimuli varying in their internal synchrony and structure. I also evaluated the acquisition of the individual components. I show that the temporal configuration and the identity of the components impact their combined and separate acquisition. Performance was favored by partial asynchrony and the initial presentation of the visual component, leading to higher acquisition of the olfactory component. This indicates that compound stimuli resembling the partially synchronous presentation of a floral display favor performance in a pollinator, thus highlighting the time dimension as crucial for the enhancement. Moreover, this supports the hypothesis that the evolution of multimodal floral signals may have been favored by the asynchrony perceived by the receiver during free flight.
Trends in pancreatic cancer incidence and mortality in the United States from 2000 to 2019; a SEER based study
Authors: Abidoye Oluseyi , Cho Young Min , Bhushan Sheena , Adewunmi Comfort , Choudhury Hasan 
Published: January 2023

Background: The annual incidence and mortality rates of pancreatic cancer has been rising. We analyzed pancreatic cancer trends by demographics and geographic location. Methods: Data was obtained from the Surveillance, Epidemiology, and End Results (SEER) registry 17 were available to assess trends of pancreatic cancer incidence and mortality from 2000 to 2019. Results: The pancreatic cancer incidence and mortality rates consistently increased over time from 2000 to 2019. Incidence of pancreatic cancer was highest in males (14; 95% Cl, 13.9,14.1) and blacks (15.4 95% Cl,15.2, 15.6). The incidence was highest in Alaska (16.2; 95% Cl, 14.1, 18.5), and lowest in Utah (10.7; 95% Cl, 10.4, 11.0). Incidence increased at 0.85% per year (95% Cl, 0.76, 0.92; P < .001). Overall incidence increased significantly for all sex, race, stage sub-groups except for Blacks (APC of 0.04%; 95% Cl, -0.14, 0.22; P = 0.649), and American Indian/Alaska natives (APC of -0.22 %; 95% Cl, -1.33, 0.89; P= 0.679). There was an overall significant increase in incidence across all states except for Alaska. Incidence-based mortality of pancreatic cancer was highest in males (12.6; 95% Cl, 12.5,12.7) and blacks (14.1; 95% Cl, 13.9, 14.3). Mortality was highest in Alaska (15.1; 95% Cl, 13.1,17.3), and lowest in Utah (9.6; 95% Cl, 9.3,9.9). Mortality increased at 0.91% per year (95% Cl, 0.32, 1.50; P = .005). The overall incidence-based mortality increased significantly only in the males APC, 0.95% (95% Cl, 0.36, 1.54; P = 0.003), females APC 1.18 (95% Cl, 0.47, 1.89; P = 0.002) and whites APC 1.05% (95% Cl, 0.45, 1.66; P = 0.002). Furthermore, there was an overall significant increase in incidence-based mortality across all states except for Alaska, Hawaii and Washington. Conclusion: Pancreatic cancer incidence and mortality rates increased overall but differed by demographics and geographic location.
A qualitative study exploring experiences, attitudes, and wellbeing of university students of a period of restricted movement and self-testing during COVID-19 “Incoming Student Wellbeing and Benefits of Serial COVID-19 testing (ISWAB)” study
Authors: McGovern Maeve , Burton Edel , Fanning Liam , Killeen Gerard , O'Sullivan Kathleen , O'Mullane John , Fitzgerald Anthony P. , Byrne Michael , Kearney Patricia M. 
Published: January 2023

Background: As part of Ireland’s response to the COVID-19 pandemic, travellers to Ireland were required to restrict movements on arrival. Worldwide compliance with measures such as quarantine and testing vary and are influenced by factors including an individual’s knowledge of trust in, and attitudes towards these measures. The aim of this study was to explore student experiences of restricted movements after entering Ireland from abroad and to assess the acceptability and feasibility of self-administered SARS-CoV-2 tests. Methods: The Incoming Student Wellbeing and the Acceptability and Benefits of serial COVID-19 testing (ISWAB) study recruited university students who travelled into Ireland and were required by national public health guidance to restrict their movements. As part of the study, students were provided with SARS-CoV-2 self-test kits. This qualitative study explored the students’ attitudes to self-testing and restricted movements using focus groups and interviews. Ethical approval was obtained. Interviews were conducted until data saturation was reached. Interview transcripts were thematically analysed. Results: Of 41 ISWAB participants, 32 agreed to participate in a follow-up qualitative study providing written consent. One focus group, two group interviews and three individual interviews were conducted in August 2021, on Microsoft Teams. Among the 11 (seven male, four female) students interviewed, self-testing was considered feasible and acceptable. Facilitators of adherence to restrictions included: support with grocery shopping and study periods coinciding with quarantine. Barriers to well-being included: living alone, being an individual who leads a social lifestyle, and the number of days of quarantine completed. Conclusions: This qualitative study demonstrated high levels of compliance with restriction of movement guidelines and self-testing, with limited impact on general well-being. Self-testing for SARS-CoV-2 was found to be practical and achievable for at home use by participants in this study. The findings of this study may inform future self-testing initiatives.
Health economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: a systematic review
Authors: Baggaley Rebecca F. , Vegvari Carolin , Dimala Christian A. , Lipman Marc , Miller Robert F. , Brown James , Degtyareva Svetlana , White Helena A. , Hollingsworth T. Déirdre , Pareek Manish 
Published: January 2023

Introduction: In lower tuberculosis (TB) incidence countries (<100 cases/100,000/year), screening and preventive treatment (PT) for latent TB infection (LTBI) among people living with HIV (PLWH) is often recommended, yet guidelines advising which groups to prioritise for screening can be contradictory and implementation patchy. Evidence of LTBI screening cost-effectiveness may improve uptake and health outcomes at reasonable cost. Methods: Our systematic review assessed cost-effectiveness estimates of LTBI screening/PT strategies among PLWH in lower TB incidence countries to identify model-driving inputs and methodological differences. Databases were searched 1980-2020. Studies including health economic evaluation of LTBI screening of PLWH in lower TB incidence countries (<100 cases/100,000/year) were included. Results: Of 2,644 articles screened, nine studies were included. Cost-effectiveness estimates of LTBI screening/PT for PLWH varied widely, with universal screening/PT found highly cost-effective by some studies, while only targeting to high-risk groups (such as those from mid/high TB incidence countries) deemed cost-effective by others. Cost-effectiveness of strategies screening all PLWH from studies published in the past five years varied from US$2828 to US$144,929/quality-adjusted life-year gained (2018 prices). Study quality varied, with inconsistent reporting of methods and results limiting comparability of studies. Cost-effectiveness varied markedly by screening guideline, with British HIV Association guidelines more cost-effective than NICE guidelines in the UK. Discussion: Cost-effectiveness studies of LTBI screening/PT for PLWH in lower TB incidence settings are scarce, with large variations in methods and assumptions used, target populations and screening/PT strategies evaluated. The limited evidence suggests LTBI screening/PT may be cost-effective for some PLWH groups but further research is required, particularly on strategies targeting screening/PT to PLWH at higher risk. Standardisation of model descriptions and results reporting could facilitate reliable comparisons between studies, particularly to identify those factors driving the wide disparity between cost-effectiveness estimates. Registration: PROSPERO CRD42020166338 (18/03/2020).
Enhancing media communication of health research: an evaluation of the Journalist in Residence Programme at the Malawi Liverpool Wellcome Trust Clinical Research Programme
Authors: Semu Phumisa Josephine , Kalera Mhango Rachel N , Makwinja Regina , Sambakunsi Rodrick , Nyirenda Deborah , Gooding Kate 
Published: January 2023

Background: In 2012, the Science Communication department at the Malawi-Liverpool Wellcome Trust Clinical Research Programme (MLW) established the Journalist in Residence Programme (JIR) to train journalists and give them support when reporting health research stories for MLW. However, the programme had not been evaluated since its inception. We assessed the impact of media training and support through this programme on the development of health research reporting in Malawi. Methods: Qualitative approaches were used to conduct in-depth interviews with five journalists, two editors, two consultants, five researchers, and three Ministry of Health officials. Two focus group discussions were also conducted with selected Community Advisory Group members in Blantyre and Chikwawa. All interviews and focus group discussions were recorded and transcribed verbatim. Data analysis was conducted using Nvivo11. Results: The JIR programme has a positive impact on the development of health research reporting in Malawi. The quantity and quality of health research stories generated from Malawi Liverpool Wellcome Trust research have increased after introducing the programme. Additionally, journalists are motivated to write health research stories as they get training and support through the programme. The health research work being implemented by Malawi-Liverpool Wellcome Trust is appreciated by policy makers and the public at large through stories published by journalists in the programme. Conclusions: This evaluation found that the JIR programme is a powerful tool for achieving the development of health research reporting in Malawi.
The genome sequence of the spotted kaleidoscope jellyfish, Haliclystus octoradiatus (James-Clark, 1863)
Authors: Blaxter Mark ,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: January 2023

We present a genome assembly from an individual Haliclystus octoradiatus (the spotted kaleidoscope jellyfish; Cnidaria; Staurozoa; Stauromedusae; Haliclystidae). The genome sequence is 262 megabases in span. Most of the assembly (98.3%) is scaffolded into nine (9) chromosomal pseudomolecules. The mitochondrial genome was also assembled and is 18.3 kilobases in length.