bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging precision neoadjuvant systemic therapy for patients with resectable non-small cell lung cancer: current status and perspectives
Authors: Godoy Luis A. , Chen Joy , Ma Weijie , Lally Jag , Toomey Kyra A. , Rajappa Prabhu , Sheridan Roya , Mahajan Shirish , Stollenwerk Nicholas , Phan Chinh T. , Cheng Danny , Knebel Robert J. , Li Tianhong 
Published: January 2023

AbstractOver the past decade, targeted therapy for oncogene-driven NSCLC and immune checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved the survival and quality of life for patients with unresectable NSCLC. Increasingly, these biomarker-guided systemic therapies given before or after surgery have been used in patients with early-stage NSCLC. In March 2022, the US FDA granted the approval of neoadjuvant nivolumab and chemotherapy for patients with stage IB-IIIA NSCLC. Several phase II/III trials are evaluating the clinical efficacy of various neoadjuvant immune checkpoint inhibitor combinations for non-oncogene-driven NSCLC and neoadjuvant molecular targeted therapies for oncogene-driven NSCLC, respectively. However, clinical application of precision neoadjuvant treatment requires a paradigm shift in the biomarker testing and multidisciplinary collaboration at the diagnosis of early-stage NSCLC. In this comprehensive review, we summarize the current diagnosis and treatment landscape, recent advances, new challenges in biomarker testing and endpoint selections, practical considerations for a timely multidisciplinary collaboration at diagnosis, and perspectives in emerging neoadjuvant precision systemic therapy for patients with resectable, early-stage NSCLC. These biomarker-guided neoadjuvant therapies hold the promise to improve surgical and pathological outcomes, reduce systemic recurrences, guide postoperative therapy, and improve cure rates in patients with resectable NSCLC.
Comparison of different methods to account for the plasmaspheric electron content in GNSS-derived ionospheric altimeter corrections and their impact on sea level trend estimation
Authors: Dettmering Denise , Schwatke Christian 
Published: January 2023

Abstract
Global ionospheric maps based on GNSS measurements are nowadays often used to correct satellite altimeter measurements when the instruments have only one frequency or measure over coasts and inland waters. If these corrections do not account for the free electron fraction over the altimeter satellites, this leads to systematic deviations in the range measurements and thus in the estimated sea level. This study compares and assesses different approaches to reduce GNSS-based corrections for the plasmaspheric electron content. It is shown that using a simple scaling with a constant factor of 0.881 gives the best results for the Jason-1 mission, while correcting with the commonly used model ratios leads to higher sea level trend artefacts and larger noise levels, especially for periods of lower solar activity. Using this approach, the sea level trend error for both Jason-1 and Sentinel-6A can be reduced to below 0.1 mm/year, with standard deviations of the differences from the dual-frequency altimeter corrections of 6.74 mm. A simple machine learning approach (boosted regression tree) is also investigated and shows promising results. However, due to the higher processing capacity requirements and the larger deviations from long-term trend, further improvements are recommended before such an approach can be used in routine processing of altimeter corrections.

Graphical Abstract
Implementation and quality of an early childhood education program for newly arrived refugee children in Germany: an observational study
Authors: Busch Julian , Buchmüller Thimo , Leyendecker Birgit 
Published: January 2023

AbstractEarly childhood education [ECE] can foster the social-emotional adjustment and development of young refugee children. Still, the large numbers of newly arriving refugee families challenge the ECE capacities of host countries. In Germany, state authorities have subsidized flexible ECE programs for refugee children in response to this situation. The goal of this study was to examine the implementation and quality of these programs. In the first study phase, we categorized the seemingly heterogeneous ECE programs and assembled measures to assess their ECE quality. In the second study phase, we evaluated the ECE quality of a randomly selected sample of these ECE programs (N = 42) using standardized observation procedures. The ECE programs were implemented differently in temporary setups (caravans, tents), improvised settings (parish rooms, refugee accommodations), or education settings (preschools, elementary schools). To evaluate ECE quality, we created an observation tool for structural quality and coded dimensions from the Classroom Assessment Scoring System Pre-K for process quality. Overall, structural quality was acceptable but differed between implementation settings. Process quality was consistently high, independent of the settings. Our findings suggest that adaptive ECE programs under a flexible childcare policy could support young refugee children after they arrive in host countries. Still, such ECE programs do not compensate for center-based ECE services because of their more vigorous emphasis on children’s social-emotional adjustment than pre-academic learning. Further research should consider adaptive assessment tools to assess ECE quality, taking into account heterogeneous program implementation strategies and the specific needs of refugee children.
New recorded diatoms in Holocene sediment cores from the Gonggeom-ji Wetland in Korea
Authors: Kwon Daeryul , Park Mirye , Lee Hoil , Lee Jin-Young , Lee Sang Deuk 
Published: January 2023

AbstractThe Gonggeom-ji reservoir is an agricultural one built for rice farming during the Proto-Three Kingdoms period and was designated as Gyeongsangbuk-do monument No. 121 because of its high historical value. The Nakdonggang National Institute of Biological Resources has been conducting paleontological and paleoenvironmental studies on major wetlands from Korea since 2016, as well as diatom, geological, and depth distribution analyses on the sedimentary soil of Gonggeom-ji. This study summarized the description and ecological characteristics of six newly recorded diatoms (Gomphonema lacusrankala, Pinnularia diandae, P. gibba var. hyaline, P. lacunarum, Sellaphora labda var. nipponica, Stauroneis angustilancea) found in samples collected through drilling in Gonggeom-ji in 2019.
Mediating role of perceived stress on the association between domestic violence and postpartum depression: cross-sectional study in Bangladesh
Authors: Tasnim Fowzia , Abedin Sumaiya , Rahman Md. Mosfequr 
Published: January 2023

Background
Postpartum depression (PPD) is a major depressive disorder developed after childbirth that negatively affects the well-being of both mother and infant. The relationship between domestic violence and the development of PPD symptoms is well documented. However, empirical evidence is lacking on how a person's perception of stress mediates this relationship.

Aims
To estimate the degree to which perceived stress may explain the association between being the victim of domestic violence and developing PPD symptoms among Bangladeshi mothers.

Method
A cross-sectional survey design was employed from October to December 2019 to collect data from 497 postpartum mothers within the first 6 months of giving birth. The associations between domestic violence victimisation and developing PPD symptoms were assessed using multivariable logistic regressions. The Karlson–Holm–Breen method was used for mediation analysis.

Results
One-third (34%) of the mothers in this sample reported experiencing PPD within 6 months. A one-item increase in the number of reported experiences (‘items’) of controlling behaviour, emotional domestic violence and physical domestic violence increased the odds of developing PPD symptoms by 27%, 40% and 31% respectively, after controlling for other variables and mediators. Furthermore, after adjusting for other variables, the mediating effect of perceived stress on the association of controlling behaviour, emotional domestic violence, physical domestic violence and any form of domestic violence with developing PPD symptoms was 45.1%, 43.0%, 31.2% and 37.5% respectively.

Conclusions
Findings suggest that perceived stress partially mediates the association between domestic violence victimisation and developing PPD symptoms. Understanding these complex relationships may help policymakers to formulate appropriate intervention strategies and support services.
Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncology Group
Authors: DuBois Steven G. , Krailo Mark D. , Glade-Bender Julia , Buxton Allen , Laack Nadia , Randall R. Lor , Chen Helen X. , Seibel Nita L. , Boron Matthew , Terezakis Stephanie , Hill-Kayser Christine , Hayes Andrea , Reid Joel M. , Teot Lisa , Rakheja Dinesh , Womer Richard , Arndt Carola , Lessnick Stephen L. , Crompton Brian D. , Kolb E. Anders , Daldrup-Link Heike , Eutsler Eric , Reed Damon R. , Janeway Katherine A. , Gorlick Richard G. 
Published: January 2023

PURPOSE Monoclonal antibodies directed against insulin-like growth factor-1 receptor (IGF-1R) have shown activity in patients with relapsed Ewing sarcoma. The primary objective of Children's Oncology Group trial AEWS1221 was to determine if the addition of the IGF-1R monoclonal antibody ganitumab to interval-compressed chemotherapy improves event-free survival (EFS) in patients with newly diagnosed metastatic Ewing sarcoma. METHODS Patients were randomly assigned 1:1 at enrollment to standard arm (interval-compressed vincristine/doxorubicin/cyclophosphamide alternating once every 2 weeks with ifosfamide/etoposide = VDC/IE) or to experimental arm (VDC/IE with ganitumab at cycle starts and as monotherapy once every 3 weeks for 6 months after conventional therapy). A planned sample size of 300 patients was projected to provide 81% power to detect an EFS hazard ratio of 0.67 or smaller for the experimental arm compared with the standard arm with a one-sided α of .025. RESULTS Two hundred ninety-eight eligible patients enrolled (148 in standard arm; 150 in experimental arm). The 3-year EFS estimates were 37.4% (95% CI, 29.3 to 45.5) for the standard arm and 39.1% (95% CI, 31.3 to 46.7) for the experimental arm (stratified EFS-event hazard ratio for experimental arm 1.00; 95% CI, 0.76 to 1.33; 1-sided, P = .50). The 3-year overall survival estimates were 59.5% (95% CI, 50.8 to 67.3) for the standard arm and 56.7% (95% CI, 48.3 to 64.2) for the experimental arm. More cases of pneumonitis after radiation involving thoracic fields and nominally higher rates of febrile neutropenia and ALT elevation were reported on the experimental arm. CONCLUSION Ganitumab added to interval-compressed chemotherapy did not significantly reduce the risk of EFS event in patients with newly diagnosed metastatic Ewing sarcoma, with outcomes similar to prior trials without IGF-1R inhibition or interval compression. The addition of ganitumab may be associated with increased toxicity.
Sex Differences in Long-Term Safety and Tolerability of GH Replacement Therapy in GH Deficient Adults
Authors: Slagboom Tessa N A , van Bunderen Christa C , van der Lely Aart Jan , Drent Madeleine L 
Published: January 2023

Abstract

Context
Previous studies report that outcomes of growth hormone (GH) replacement therapy (GHRT) might be less beneficial in growth hormone deficient (GHD) women compared with men.

Objective
This study investigated possible contributing factors regarding this previously found sex difference.

Methods
This retrospective cohort study, conducted at a nationwide outpatient clinic (the Dutch National Registry of GH Treatment in Adults), included Dutch adult GHD men (n = 1335) and women (n = 1251) treated with GHRT. The patients’ baseline characteristics, details of GHRT, and the tolerability and long-term safety of GHRT were measured.

Results
During treatment, sensitivity analysis showed that insulin-like growth factor-1 (IGF-1) SD scores remained subnormal more often in women (P &lt; 0.001), while scores above normal were more frequent in men (P &lt; 0.001). Women reported more adverse events (P &lt; 0.001), especially symptoms related to fluid retention, and more often needed a dose reduction or temporary stop of GHRT (P = 0.001). In percentages, both sexes equally discontinued GHRT, as was also true for the risk in developing type 2 diabetes mellitus, benign neoplasms, and tumor recurrence. The risk of developing malignant neoplasms was higher in men (P = 0.012).

Conclusion
Data obtained from the Dutch National Registry of GH Treatment in Adults indicate that GHD women might be treated suboptimally, reflected as lower IGF-1 status and lower GHRT tolerability, leading to more frequent changes in treatment regimen but not discontinuation of GHRT. Regarding long-term safety, we found a higher risk for development of malignancies in GHD men.
Acute stress and restricted diet reduce bill-mediated heat dissipation in the song sparrow (Melospiza melodia): implications for optimal thermoregulation
Authors: Zuluaga Juan D. , Danner Raymond M. 
Published: January 2023

ABSTRACT
We used thermal imaging to show that two environmental factors – acute stress and diet – influence thermoregulatory performance of a known thermal window, the avian bill. The bill plays important roles in thermoregulation and water balance. Given that heat loss through the bill is adjustable through vasoconstriction and vasodilation, and acute stress can cause vasoconstriction in peripheral body surfaces, we hypothesized that stress may influence the bill's role as a thermal window. We further hypothesized that diet influences heat dissipation from the bill, given that body condition influences the surface temperature of another body region (the eye region). We measured the surface temperature of the bills of song sparrows (Melospiza melodia) before, during and after handling by an observer at 37°C ambient temperature. We fed five birds a restricted diet intended to maintain body mass typical of wild birds, and we fed six birds an unrestricted diet for 5 months prior to experiments. Acute stress caused a decrease in the surface temperature of the bill, resulting in a 32.4% decrease in heat dissipation immediately following acute stress, before recovering over approximately 2.3 min. The initial reduction and subsequent recovery provide partial support for the hemoprotective and thermoprotective hypotheses, which predict a reduction or increase in peripheral blood flow, respectively. Birds with unrestricted diets had larger bills and dissipated more heat, indicating that diet and body condition influence bill-mediated heat dissipation and thermoregulation. These results indicate that stress-induced vascular changes and diet can influence mechanisms of heat loss and potentially inhibit optimal thermoregulation.
An investigation of syrinx morphometry and sound frequency association during the chirping period in lovebirds (Agapornis fischeri)
Authors: Dewi Cytra Meyliana Surya , Dhamayanti Yeni , Fikri Faisal , Purnomo Agus , Khairani Shafia , Chhetri Shekhar , Purnama Muhammad Thohawi Elziyad 
Published: January 2023

Background: In the issue of biodiversity, the domestication of birds as pets and trade animals requires special attention as a conservation effort. Lovebirds (Agapornis fischeri) are popular birds worldwide, due to their varied ornamentation and melodic chirping sound. Syrinx structure is suspected to be the main source of sound production during the chirping period. This study aimed to investigate syrinx morphometry and its correlation with sound frequency produced in lovebirds. Methods: A total of 24 lovebirds of different ages and gender were investigated. Polymerase chain reaction method was performed to determine lovebird gender, meanwhile bird age was identified based on post-hatch recordings at the breeding farm. Thus, we enrolled male (n=12) and female (n=12) lovebirds aged 2 (n=4), 3 (n=4), and 4 (n=4) months in the investigation group, respectively. Fast Fourier Transform (FFT) was performed to evaluate sound frequency during chirping period. Then, syrinx morphometry was identified using a topographic approach and methylene blue staining. Each variable was evaluated with Image J software and vernier caliper. Results: Based on a topographical approach, we reported the general cartilage structure of the tracheosyringeal, bronchosyringeal, paired protrusions, tracheolateral muscles, sternotracheal muscles, and syringeal muscles in lovebird syrinx. In particular, the tympaniform membranes lateral lead a crucial role in modulating the frequency of male lovebirds more significantly (p=0,009) compared to female. On the other hand, the tympaniform membranes lateral dexter (p=0,02) and sinister (p=0,05) in females showed wider compared to male. We also reported a negative correlation between sound frequency compared to tympaniform membranes lateral dexter (y = -913,56x + 6770,8) and sinister (y = -706,16x + 5736). Conclusions: It can be concluded that the tympaniform membranes lateral produced the lovebirds’ primary sound. The sound frequency of male lovebirds was higher compared to female, however negatively correlated with the area of tympaniform membranes lateral.
Managerial Overconfidence and Market Feedback Effects
Authors: Banerjee Suman , Huang Shiyang , Nanda Vikram , Xiao Steven Chong 
Published: January 2023

We show that managerial learning from stock prices can lead to feedback loop vulnerability: corrective actions based on perceived negative market signals reduce the sensitivity of asset payoffs to stock market information. Less sensitivity discourages liquidity provision and increases the price impact of liquidity shocks. Interestingly, overconfident managers who disregard stock price information may be less vulnerable to the adverse price impact of nonfundamental liquidity shocks. Our empirical evidence strongly supports the model’s underlying premises and predictions: First, investment decisions of overconfident CEOs are significantly less responsive to stock price fluctuations. Second, the price impact of liquidity shocks, for example, mutual fund fire sales, is substantially smaller for firms with overconfident CEOs. This paper was accepted by Gustavo Manso, finance. Funding: S. Huang gratefully acknowledges the financial support from the Hong Kong General Research Fund [GRF Project Code 17503317]. Supplemental Material: Data and the internet appendix are available at https://doi.org/10.1287/mnsc.2022.4625 .
An Analysis of Incentive Schemes for Participant Retention in Clinical Studies
Authors: Song Xueze , Mehrotra Mili , Rajapakshe Tharanga 
Published: January 2023

Problem definition: Participant retention is one of the significant issues faced by clinical studies. This paper analyzes the economic impact of combining two mechanisms (monetary payments to participants and effort exerted during a clinical study) observed in practice to improve retention. Methodology/results: Given an incentive scheme, under full information and information asymmetry regarding participants’ characteristics, we model the problem of identifying optimal payment and effort to improve retention for a clinical study using a nonlinear integer program. We propose polynomial-time algorithms to solve the problem under full information for a participant-specific linear payment scheme and two commonly observed incentive schemes: Fixed Payment (FP) and Logistics Reimbursement (RE). We also provide exact methods to solve the problem under information asymmetry for the FP and RE schemes. We conduct a comprehensive computational study to gain insights into the relative performance of these schemes. Under full information, the participant-specific scheme can reduce the retention cost by about 46%, on average, compared with that under the RE and FP schemes. Information asymmetry causes the RE scheme to be more favorable than the FP scheme in a wider variety of clinical studies. Further, the value of acquiring participants’ characteristics information is significant under the FP scheme compared with that under the RE scheme. Managerial implications: The determination of monetary payments is ad hoc in practice. Further, an economic analysis of the two mechanisms for improving retention in clinical studies is absent. Given the participants and the clinical study characteristics under full information and information asymmetry, our analysis enables a decision maker to identify an optimum incentive scheme, monetary payment, and effort level for improving retention. Further, our analysis allows a clinical study decision maker to assess budget requirements to improve retention and adapt the incentive payments to Institutional Review Board guidelines, if any. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1184 .
Using Machine Learning to Include Planners’ Preferences in Railway Crew Scheduling Optimization
Authors: Gattermann-Itschert Theresa , Poreschack Laura Maria , Thonemann Ulrich W. 
Published: January 2023

In crew scheduling, optimization models can become complex when a large number of penalty terms is included in the objective function to take planners’ preferences into account. Planners’ preferences often include nonmonetary aspects for which both the mathematical formulation and the assignment of appropriate penalty costs can be difficult. We address this problem by using machine learning to learn and predict planners’ preferences. We train a random forest classifier on planner feedback regarding duties from their daily work in railway crew scheduling. Our data set contains over 16,000 duties that planners labeled as good or bad. The trained model predicts the probability that a duty is perceived as bad by the planners. We present a novel approach to replace the large construct of penalty terms in a crew scheduling optimization model by a single term that penalizes duties proportionally to the predicted probability of being assessed as unfavorable by a planner. By integrating this probability into the optimization model, we generate schedules that include more duties with preferred characteristics. We increase the mean planner acceptance probability by more than 12% while only facing a marginal increase in costs compared with the original approach that utilizes a set of multiple penalty terms. Our approach combines machine learning to detect complex patterns regarding favorable duty characteristics and optimization to create feasible and cost-efficient crew schedules. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.1196 .