bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-resistant Bacteria to Antibiotics in Hospitals: The Case of Neonatology Services of the University Hospitals Centers of Abidjan, Côte d'Ivoire
Authors: Arlette Afran Sidjè , Valérie M’Bengue Gbonon , Bertin Tiékoura Konan , Bertin Kipré Guédé , Anatole Toty Abalé , Fernique Konan , Nathalie Guessennd , Simon-Pierre N’Guetta Assanvo , Mireille Dosso 
Published: May 2023

Background: Multidrug-resistant bacteria (MDR) represent a global health scourge. Their emergence in hospital services complicates the clinical management of infections caused in particular in immunocompromised persons. The objective of our work was to evaluate the prevalence of MDR in the neonatal services of the University Hospitals Centers of Abidjan.
Materials and Methods: The present study took place from September to November 2020 and from January to June 2021. The samples collected consisted of venous blood samples for blood cultures, rectal swabs from newborns, nasal and hand swabs from health care workers, and swabs from inert surfaces and neonatal care equipment. Bacterial identification methods, antibiotic susceptibility testing, and Chi-square testing were performed.
Results: A total of 513 samples were obtained from which 215 organisms were isolated and identified. These bacteria consisted of 52.1% Gram-negative bacilli, of which 77.7% were Enterobacteriaceae and 47.9% Gram-positive cocci. Klebsiella pneumoniae (K. pneumoniae) (25.6%), coagulase-Negative Staphylococcus (CoNS) (24.6%), and Staphylococcus aureus (S. aureus) (23.2%) were the most isolated bacteria. The overall prevalence of MDR was 73.9%. The main antibiotic resistance phenotypes described were the production of Broad Spectrum β-lactamases (ESBL) in 71.9% of Enterobacteriaceae and methicillin resistance (Meti-R) in 75.6% of Staphylococcus. ESBL-producing Enterobacteriaceae (E-ESBL) were mainly observed in rectal carriage and Meti-R strains in blood cultures in newborns in the respective proportions of 45.6% and 56.4%.
Conclusion: In our work, the results obtained showed a high prevalence of MDR in neonatal services and newborns are the most affected subjects. Improving hygiene rules and control and rationalizing the use of antibiotics are highly recommended control strategies to reduce the hospital dissemination of MDR.
Resource allocation of backscatter communication based on reconfigurable intelligent surface
Authors: Wang Zhifei , Cao Qihao 
Published: May 2023

AbstractIn this article, we propose a double reconfigurable intelligent surface (RIS)‐aided ambient backscatter communication (AmBC) network combined with non‐orthogonal multiple access (NOMA) technology, which not only successfully assists the base station (BS) in connecting with the cell edge user, but also enhances backscatter communication rate, energy efficiency, and spectrum efficiency. In an effort to obtain the highest backscatter communication rate, we design a RIS and BS‐based resource allocation problem which is solved by determining the optimal phase shifts of RISs and the optimal power allocation for signals of NOMA users. We break it down into two smaller challenges in order to discover the best solution. For one thing, we iterate the optimal phase shifts between the two RIS combinations using an alternating optimization technique. For another, the bisection method is used to provide the NOMA user with the ideal power allocation. Finally, the results of the simulation substantiate the viability of the proposed scheme.
Surface Energy Mediated Sulfur Vacancy of ZnIn2S4 Atomic Layers for Photocatalytic H2O2 Production
Authors: Zhang Kailian , Dan Meng , Yang Jingfei , Wu Fengxiu , Wang Leigang , Tang Hua , Liu Zhao‐Qing 
Published: May 2023

AbstractConstructing rich defect active site structure for material design is still a great challenge. Herein, a simple surface engineering strategy is demonstrated to construct one‐unit‐cell ZnIn2S4 atomic layers with the modulated surface energy of S vacancy. Rich surface energy can regulate and control the rich S vacancy, which ensures rich active sites, higher charge density and effective carrier transport. As a result, the ZnIn2S4 atomic layers with rich surface energy affords an obvious enhancement in H2O2 productive rate of 1592.04 µmol g−1 h−1, roughly 14.58 times superior to that with poor surface energy. Moreover, the in situ infrared diffuse reflection spectrum indicates that S vacancy as the oxygen reduction reaction active site is responsible for the critical intermediate *O2− and *OOH, corresponding to two‐electron oxygen reduction reaction. This study provides a valuable insight and guidance for constructing controllably defects to achieve highly efficient H2O2 production.
MnO2 Coated Mesoporous PdPt Nanoprobes for Scavenging Reactive Oxygen Species and Solving Acetaminophen‐Induced Liver Injury
Authors: Lu Yi , Pan Xinni , Cao Cheng , Fan Shanshan , Tan Haisong , Cui Shengsheng , Liu Yanlei , Cui Daxiang 
Published: May 2023

AbstractAs one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen‐induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase‐like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)‐scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs’ therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.
A Smart Responsive Fluorescence‐MR Nanoprobe for Monitoring Tumor Response to Immunotherapy
Authors: Li Minghua , Tang Junjun , Lin Chao , Shen Aijun , Ma Xiaolong , Wu Jiaqi , Gao Xiaolong , Wang Peijun 
Published: May 2023

AbstractAccurately evaluating tumor responses to immunotherapy is clinically relevant. However, non‐invasive, real‐time visualization techniques to evaluate tumor immunotherapy are still lacking. Herein, a smart responsive fluorescence‐MR dual‐modal nanoprobe, QM(GP)‐MZF(CP), is reported that can be targeted for cleavage by the cytotoxic T cell activation marker granzyme B and the apoptosis‐related marker cysteine‐aspartic acid‐specific protease 3 (Caspase‐3). The probe uses quinoline‐malononitrile (QM), an aggregation‐induced emission luminogen, and Mn‐Zn ferrite magnetic nanoparticles (MZF‐MNPs), a T2‐weighted imaging (T2WI) contrast agent, as imaging molecules that are linked with the substrate peptides specific to granzyme B and Caspase‐3. Therefore, both granzyme B and Caspase‐3 can target and cleave the substrate peptides in QM(GP)‐MZF(CP). Via aggregation‐induced fluorescence imaging of QM and the aggregation‐induced T2WI‐enhanced imaging effect of MZF‐MNPs, the status of T cells after tumor immunotherapy and the subsequent triggering of tumor cell apoptosis can be determined to identify tumor responsiveness to immunotherapy and thereby evaluate the effectiveness of this therapy in the early stages of treatment.
Highly Sensitive X‐Ray Detector Made of Large Lead‐Free Perovskite Cs3Bi2I9 Single Crystals with Anisotropic Response
Authors: Yang Manman , Li Anfeng , Hao Xia , Wu LiLi , Tian Wenbo , Yang Dingyu , Zhang Jingquan 
Published: May 2023

AbstractDirect X‐ray detectors require high‐quality and large‐size materials to reduce radiation hazards. As an all‐inorganic lead‐free perovskite, Cs3Bi2I9 has good prospects for research and applications in the field of X‐ray detection. A refined evaporation method is proposed for the growth of Cs3Bi2I9 single crystals (SCs), and a high‐quality SC with a size of 18 × 20.5 × 3 mm3 is obtained. Due to the anisotropy of Cs3Bi2I9 SCs, two different device structures, vertical and coplanar, are designed. The coplanar device has a higher sensitivity of 59 464.4 µC Gyair−1 cm−2, while the vertical device performs better on the limit of detection (LoD), with an LodD as low as 1.27 nGyair s−1.
Dual Phase‐Conversion Strategy Reinforced Otitis Media Therapy Using Metastable Iron Sulfide‐Loaded Thermosensitive Hydrogel
Authors: Li Ziwei , Gong Rui , Abbas Ghulam , Feng Xiaozhou , Wang Xiaonan , Wang Jie , Huang Haibing , Han Jinghong , Zhang Bairu , Nie Guohui , Gao Lizeng , Ding Hui 
Published: May 2023

AbstractOtitis media (OM) is a common bacterial disease in otolaryngology, which has a high incidence rate and seriously affects people's health and quality of life. The abuse of antibiotics is a severe public health problem worldwide, contributing to the emergence of multidrug‐resistant bacteria and vestibular/cochlear damage, leading to sensorineural hearing loss. In this study, PLGA‐PEG‐PLGA thermosensitive hydrogel (PPPTH) is employed as a drug delivery carrier to deliver metastable cystine‐denoted iron sulfides compounds (Cys‐nFeS) to treat Staphylococcus aureus (S. aureus)‐induced OM by topical injection through the eardrum. The combination of Cys‐nFeS and PPPTH (Cys‐nFeS/PPPTH) prevents Cys‐nFeS from rapidly oxidizing and constantly releasing Cys‐nFeS, fulfilling the goal of continuous therapy. The destructive effect of Cys‐nFeS/PPPTH on bacteria and bacterial biofilms in vitro and in vivo is evaluated. The results show that Cys‐nFeS/PPPTH has good antibacterial and biofilm destruction effects, low cytotoxicity, and excellent anti‐inflammatory effects. Moreover, it is found that Cys‐nFeS/PPPTH can repair S. aureus‐induced hearing loss in OM. This study demonstrates the promising potential of Cys‐nFeS/PPPTH for middle ear delivery and antibacterial treatment.
Ultrasensitive NGS MRD assessment in Ph+ ALL: Prognostic impact and correlation with RT‐PCR for BCR::ABL1
Authors: Short Nicholas J. , Jabbour Elias , Macaron Walid , Ravandi Farhad , Jain Nitin , Kanagal‐Shamanna Rashmi , Patel Keyur P. , Loghavi Sanam , Haddad Fadi G. , Yilmaz Musa , Issa Ghayas C. , Kebriaei Partow , Kornblau Steven M. , Pelletier Sarah , Flores Wilmer , Matthews Jairo , Garris Rebecca , Kantarjian Hagop 
Published: May 2023

AbstractReverse transcription polymerase chain reaction (RT‐PCR) for BCR::ABL1 is the most common and widely accepted method of measurable residual disease (MRD) assessment in Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ ALL); however, RT‐PCR may not be an optimal measure of MRD in many cases of Ph+ ALL. We evaluated the clinical impact of a highly sensitive next‐generation sequencing (NGS) MRD assay (sensitivity of 10−6) and its correlation with RT‐PCR for BCR::ABL1 in patients with Ph+ ALL. Overall, 32% of patients had a discordance between MRD assessment by RT‐PCR and NGS, and 31% of patients who achieved NGS MRD negativity were PCR+ at the same timepoint. Among eight patients with long‐term detectable BCR::ABL1 by PCR, six were PCR+/NGS−. These patients generally had stable PCR levels that persisted despite therapeutic interventions, and none subsequently relapsed; in contrast, patients who were PCR+/NGS+ had more variable PCR values that responded to therapeutic intervention. In a separate cohort of prospectively collected clinical samples, 11 of 65 patients (17%) with Ph+ ALL who achieved NGS MRD negativity had detectable BCR::ABL1 by PCR, and none of these patients relapsed. Relapse‐free survival and overall survival were similar in patients who were PCR+/NGS− and PCR−/NGS−, suggesting that PCR for BCR::ABL1 did not provide additional prognostic information in patients who achieved NGS MRD negativity. NGS‐based assessment of MRD is prognostic in Ph+ ALL and identifies patients with low‐level detectable BCR::ABL1 who are unlikely to relapse nor to benefit from therapeutic interventions.
Synthesis of Chiral Diarylmethylamines by Cobalt‐Catalyzed Enantioselective C‐H Alkoxylation
Authors: Wang Zhen‐Kai , Wu Yong‐Jie , Yao Qi‐Jun , Shi Bing‐Feng 
Published: May 2023

AbstractChiral diarylmethylamines (DAMA) are important structural motifs widely present in pharmaceuticals, natural products, and chiral ligands. Herein, we reported a highly enantioselective synthesis of chiral DAMAs via cobalt‐catalyzed enantioselective C−H alkoxylation strategy. The reaction features easy operation, the use of earth‐abundant and cost‐efficient cobalt(II) catalyst, and readily available ligand. A range of chiral DAMAs were efficiently synthesized in high yields with excellent enantioselectivities (up to 90 % yield and up to 99 % ee) through desymmetrization and parallel kinetic resolution. Moreover, this protocol was also compatible with the synthesis of chiral benzylamines via kinetic resolution.
The chemicals between us—First results of the cluster analyses on anatomy embalming procedures in the German‐speaking countries
Authors: Kerner Alexander Michael , Biedermann Uta , Bräuer Lars , Caspers Svenja , Doll Sara , Engelhardt Maren , Filler Timm J. , Ghebremedhin Estifanos , Gundlach Stefanie , Hayn‐Leichsenring Gregor U. , Heermann Stephan , Hettwer‐Steeger Ingrid , Hiepe Laura , Hirt Bernhard , Hirtler Lena , Hörmann Romed , Kulisch Christoph , Lange Tobias , Leube Rudolf , Meuser Annika Hela , Müller‐Gerbl Magdalena , Nassenstein Christina , Neckel Peter H. , Nimtschke Ute , Paulsen Friedrich , Prescher Andreas , Pretterklieber Michael , Schliwa Stefanie , Schmidt Katja , Schmiedl Andreas , Schomerus Christof , Schulze‐Tanzil Gundula , Schumacher Udo , Schumann Sven , Spindler Volker , Streicher Johannes , Tschernig Thomas , Unverzagt Axel , Valentiner Ursula , Viebahn Christoph , Wedel Thilo , Weigner Janet , Weninger Wolfgang J. , Westermann Jürgen , Weyers Imke , Waschke Jens , Hammer Niels 
Published: May 2023

AbstractHands‐on courses utilizing preserved human tissues for educational training offer an important pathway to acquire basic anatomical knowledge. Owing to the reevaluation of formaldehyde limits by the European Commission, a joint approach was chosen by the German‐speaking anatomies in Europe (Germany, Austria, Switzerland) to find commonalities among embalming protocols and infrastructure. A survey comprising 537 items was circulated to all anatomies in German‐speaking Europe. Clusters were established for “ethanol”‐, formaldehyde‐based (“FA”), and “other” embalming procedures, depending on the chemicals considered the most relevant for each protocol. The logistical framework, volumes of chemicals, and infrastructure were found to be highly diverse between the groups and protocols. Formaldehyde quantities deployed per annum were three‐fold higher in the “FA” (223 L/a) compared to the “ethanol” (71.0 L/a) group, but not for “other” (97.8 L/a), though the volumes injected per body were similar. “FA” was strongly related to table‐borne air ventilation and total fixative volumes ≤1000 L. “Ethanol” was strongly related to total fixative volumes >1000 L, ceiling‐ and floor‐borne air ventilation, and explosion‐proof facilities. Air ventilation was found to be installed symmetrically in the mortuary and dissection facilities. Certain predictors exist for the interplay between the embalming used in a given infrastructure and technical measures. The here‐established cluster analysis may serve as decision supportive tool when considering altering embalming protocols or establishing joint protocols between institutions, following a best practice approach to cater toward best‐suited tissue characteristics for educational purposes, while simultaneously addressing future demands on exposure limits.
Tender love and disassembly: How a TLDc domain protein breaks the V‐ATPase
Authors: Wilkens Stephan , Khan Md. Murad , Knight Kassidy , Oot Rebecca A. 
Published: May 2023

AbstractVacuolar ATPases (V‐ATPases, V1Vo‐ATPases) are rotary motor proton pumps that acidify intracellular compartments, and, when localized to the plasma membrane, the extracellular space. V‐ATPase is regulated by a unique process referred to as reversible disassembly, wherein V1‐ATPase disengages from Vo proton channel in response to diverse environmental signals. Whereas the disassembly step of this process is ATP dependent, the (re)assembly step is not, but requires the action of a heterotrimeric chaperone referred to as the RAVE complex. Recently, an alternative pathway of holoenzyme disassembly was discovered that involves binding of Oxidation Resistance 1 (Oxr1p), a poorly characterized protein implicated in oxidative stress response. Unlike conventional reversible disassembly, which depends on enzyme activity, Oxr1p induced dissociation can occur in absence of ATP. Yeast Oxr1p belongs to the family of TLDc domain containing proteins that are conserved from yeast to mammals, and have been implicated in V‐ATPase function in a variety of tissues. This brief perspective summarizes what we know about the molecular mechanisms governing both reversible (ATP dependent) and Oxr1p driven (ATP independent) V‐ATPase dissociation into autoinhibited V1 and Vo subcomplexes.
Sustainability reporting: Current state and challenges
Authors: Paridhi  , Arora Ashima 
Published: May 2023

AbstractThere exists a huge difference in sustainability reporting adoption & implementation within and between countries which affect achievement of desired results at global level for environmental protection and social development. This study summarises and analyses 133 studies of sustainability reporting published between year 2004 and 2022 in web of sciences (WoS) database through Bibliometric Analysis and also used Theory, Context, Characteristic Methodology framework to represent the state of research in this field for the first time. The study is divided in two sections (1) develop an understanding on sustainability reporting trends and thematic evolution, and (2) discussion on challenges of sustainability reporting adoption and implementation. The present study consolidates the state of research on sustainability reporting. The study finds a thematic shift since 2017 onwards and a significant increase in publications since 2018. It identifies four major thematic clusters namely, sustainability reporting, board gender diversity, content analysis, and ESG disclosure which reveals that ESG reporting, ESG disclosures, and sustainability stakeholder impact assessment has high potential for future research. It also contributes by identifying most prominent theories in the field viz stakeholder, legitimacy and institutional theory and preferred methodology as qualitative research. It finds emerging themes as Sustainability Reporting Quality, ESG disclosure, cross‐country evaluation and also highlights most relevant keywords and trends in the research field. Study recognises lack of common definition and conceptual understanding, standards measurement metrics and cross‐country evaluations as major challenges which stands as big problem at policy formation and implementation stage.
Deubiquitinating enzyme USP10 promotes osteosarcoma metastasis and epithelial–mesenchymal transition by stabilizing YAP1
Authors: Deng Jianyong , Yi Xuan , Feng Zuxi , Peng Jie , Li Dan , Li Chen , Deng Binbin , Liu Shuaigang , Sahu Souradeep , Hao Liang 
Published: May 2023

AbstractBackgroundOsteosarcoma (OS) is a fatal adolescent tumor, which is susceptible to remote metastases at an early stage, and its treatment remains a major challenge. ubiquitin‐specific protease 10 (USP10) is primarily located in the cytoplasm and can therefore deubiquitinate various cytoplasmic proteins. However, the expression and mechanism of USP10 in OS remain ambiguous. The aim of this study was to explore how USP10 affects Yes‐associated protein1 (YAP1) to influence the metastasis and epithelial–mesenchymal transition (EMT).MethodsWestern blotting, qRT‐PCR, and immunohistochemical (IHC) analyses were performed to evaluate USP10 and YAP1 levels. Using wound healing and transwell tests, the roles and molecular pathways of USP10 and YAP1 ability to migrate and invade of OS were investigated, and cell morphological alterations were examined using phalloidin staining.ResultsOur results indicated that USP10, a new type of deubiquitinating protease, is increased in OS tissues and cells contrasted with adjacent healthy tissues. Overexpression of USP10 correlated with tumor size, distant metastasis, and TNM stage, and was an independent factor of poor prognosis in OS patients. Also, USP10 expression is closely connected with the incident of OS metastasis and tumor size. Functional assays revealed that USP10 knockdown suppressed cell migrating and invading ability and inhibited the EMT of OS cells in vivo and in vitro. In addition, we showed that USP10 knockdown decreased the levels of YAP1, which is an important positive regulator of migration and invasion in many cancers. We also found a significant positive correlation between USP10 and YAP1 levels, further demonstrating that USP10‐induced migration and EMT are based on YAP1 in OS cells. In a mechanistic way, USP10 stabilizes the expression of YAP1 by mediating its deubiquitination in OS cells.ConclusionTogether, this study showed that USP10 can directly interact with YAP1 to reduce ubiquitinated YAP1, thereby stabilizing its protein levels and affecting EMT and distant metastasis in OS cells.
Superoleophobic Polyketone Nanofiber Membranes for Efficient Separation of Oil/water Emulsions
Authors: Hou Jian , Choi Jinwon , Yun Jaehan , Jang Wongi , Kim Jun‐Hyun , Byun Hongsik 
Published: May 2023

AbstractElectrospun nanofiber membranes derived from polyketone (PK) are precisely fabricated to exhibit an excellent separation efficiency for oil/water emulsions. The fiber diameter and pore size of the membrane are controlled by introducing NaOH to the precursor solution prior to electrospinning. The surface properties of the nanofibers are then controlled by the removal of NaOH with water and reduction of functional groups with sodium borohydride (NaBH4) to exhibit an air‐water superhydrophilicity and underwater superoleophobicity. This surface conversion process is easily monitored by the water contact angle and the underwater oil contact angle. Oil/water emulsions, including toluene, soybean oil, and hexadecane are filtered through the membranes to examine their separation efficiency and flux using total organic carbon and UV‐Vis measurements. The optimized membrane exhibits the minimum 97 % separation efficiency for all three oil/water emulsions and recyclability without notably losing its flux under gravity‐driven filtration conditions.
Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer
Authors: Zhang Linlin , Wang Xiangdong 
Published: May 2023

AbstractThe deregulation of the metabolic network of cancer cells is now considered one of the characteristics of cancer. Aberrant lipid synthesis and additional lipid intake promote the rapid proliferation of cancer cells. In mammals, there are five members of the long‐chain acyl‐CoA synthase family involved in de novo lipid synthesis, fatty acid (FA) degradation and subsequent membrane modification. Their main function is to activate long‐chain FAs through the CoA chain link, and these conjugates are mainly used for the synthesis of triglycerides. In a variety of cancers, the expression of long‐chain acyl‐CoA synthetases (ACSLs) is different, and it also changes in different cancer subtypes. This review summarized recent research on the biological functions of ACSL, as well as recent advances in related diseases, and explored the potential therapeutic role of ACSL genes.