bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waves in Magnetosheath Jets—Classification and the Search for Generation Mechanisms Using MMS Burst Mode Data
Authors: Krämer E. , Hamrin M. , Gunell H. , Karlsson T. , Steinvall K. , Goncharov O. , André Mats 
Published: June 2023

AbstractMagnetosheath jets are localized dynamic pressure enhancements in the magnetosheath. We make use of the high time resolution burst mode data of the Magnetospheric Multiscale mission for an analysis of waves in plasmas associated with three magnetosheath jets. We find both electromagnetic and electrostatic waves over the frequency range from 0 to 4 kHz that can be probed by the instruments on board the MMS spacecraft. At high frequencies we find electrostatic solitary waves, electron acoustic waves, and whistler waves. Electron acoustic waves and whistler waves show the typical properties expected from theory assuming approximations of a homogeneous plasma and linearity. In addition, 0.2 Hz waves in the magnetic field, 1 Hz electromagnetic waves, and lower hybrid waves are observed. For these waves the approximation of a homogeneous plasma does not hold anymore and the observed waves show properties from several different basic wave modes. In addition, we investigate how the various types of waves are generated. We show evidence that, the 1 Hz waves are connected to gradients in the density and magnetic field. The whistler waves are generated by a butterfly‐shaped pitch‐angle distribution and the electron acoustic waves by a cold electron population. The lower hybrid waves are probably generated by currents at the boundary of the jets. As for the other waves we can only speculate about the generation mechanism due to limitations of the instruments. Studying waves in jets will help to address the microphysics in jets which can help to understand the evolution of jets better.
Remote Sensing of Riverbank Migration Using Particle Image Velocimetry
Authors: Chadwick Austin J. , Greenberg Evan , Ganti Vamsi 
Published: June 2023

AbstractMobile river channels endanger human life and property and over centuries shape ecosystems, landscapes, and stratigraphy. Quantifying channel movements from remote sensing is difficult, in part due to the diversity of river mobility processes (e.g., channel migration, cutoffs, avulsion) and planform morphologies (e.g., meandering, braided). Here, we present a framework for quantifying riverbank migration from remote sensing that upscales recent methodological advances from laboratory flume studies utilizing particle image velocimetry (PIV). We apply PIV to image time series of 21 rivers worldwide, showing PIV ignores cutoff and avulsion processes by design and is well suited for tracking riverbank migration regardless of planform morphology. We show that PIV‐derived results for riverbank migration are consistent with published results from centerline‐ and bank‐based Lagrangian methods. Unlike existing methods, PIV offers a grid‐based Eulerian framework where defining channel centerlines is unnecessary and quantified uncertainty in riverbank positions is propagated into uncertainty in migration rates. PIV offers means to efficiently extract global patterns in riverbank migration from decades of satellite data, as well as investigate river response to climate change and human activities in our rapidly changing world.
Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation
Authors: Dongiovanni Paola , Meroni Marica , Casati Sara , Goldoni Riccardo , Thomaz Douglas Vieira , Kehr Nermin Seda , Galimberti Daniela , Del Fabbro Massimo , Tartaglia Gianluca M. 
Published: June 2023

AbstractSeveral chronic disorders including type 2 diabetes (T2D), obesity, heart disease and cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early assessment of chronic disorders encompass acute phase proteins (APP), cytokines and chemokines, pro-inflammatory enzymes, lipids and oxidative stress mediators. These substances enter saliva through the blood flow and, in some cases, there is a close relation between their salivary and serum concentration. Saliva can be easily collected and stored with non-invasive and cost-saving procedures, and it is emerging the concept to use it for the detection of inflammatory biomarkers. To this purpose, the present review aims to discuss the advantages and challenges of using standard and cutting-edge techniques to discover salivary biomarkers which may be used in diagnosis/therapy of several chronic diseases with inflammatory consequences with the pursuit to possibly replace conventional paths with detectable soluble mediators in saliva. Specifically, the review describes the procedures used for saliva collection, the standard approaches for the measurement of salivary biomarkers and the novel methodological strategies such as biosensors to improve the quality of care for chronically affected patients.
A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis
Authors: Senapati Jayastu , Muftuoglu Muharrem , Ishizawa Jo , Abbas Hussein A. , Loghavi Sanam , Borthakur Gautam , Yilmaz Musa , Issa Ghayas C. , Dara Samuel I. , Basyal Mahesh , Li Li , Naqvi Kiran , Pourebrahim Rasoul , Jabbour Elias J. , Kornblau Steven M. , Short Nicholas J. , Pemmaraju Naveen , Garcia-Manero Guillermo , Ravandi Farhad , Khoury Joseph , Daver Naval , Kantarjian Hagop M. , Andreeff Michael , DiNardo Courtney D. 
Published: June 2023

AbstractIn TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2 inhibitor (MDM2i) monotherapy in AML has shown modest responses in clinical trials but combining options of MDM2i with other potent AML-directed agents like cytarabine and venetoclax could improve its efficacy. We conducted a phase I clinical trial (NCT03634228) to study the safety and efficacy of milademetan (an MDM2i) with low-dose cytarabine (LDAC)±venetoclax in adult patients with relapsed refractory (R/R) or newly diagnosed (ND; unfit) TP53 wild-type AML and performed comprehensive CyTOF analyses to interrogate multiple signaling pathways, the p53-MDM2 axis and the interplay between pro/anti-apoptotic molecules to identify factors that determine response and resistance to therapy. Sixteen patients (14 R/R, 2 N/D treated secondary AML) at a median age of 70 years (range, 23–80 years) were treated in this trial. Two patients (13%) achieved an overall response (complete remission with incomplete hematological recovery). Median cycles on trial were 1 (range 1–7) and at a median follow-up of 11 months, no patients remained on active therapy. Gastrointestinal toxicity was significant and dose-limiting (50% of patients ≥ grade 3). Single-cell proteomic analysis of the leukemia compartment revealed therapy-induced proteomic alterations and potential mechanisms of adaptive response to the MDM2i combination. The response was associated with immune cell abundance and induced the proteomic profiles of leukemia cells to disrupt survival pathways and significantly reduced MCL1 and YTHDF2 to potentiate leukemic cell death. The combination of milademetan, LDAC±venetoclax led to only modest responses with recognizable gastrointestinal toxicity. Treatment-induced reduction of MCL1 and YTHDF2 in an immune-rich milieu correlate with treatment response.
Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer
Authors: Zhang Xiao-Wei , Li Jing-Yi , Li Lin , Hu Wen-Qian , Tao Yan , Gao Wen-Yan , Ye Zi-Nuo , Jia Hao-Yuan , Wang Jia-Nan , Miao Xiao-Kang , Yang Wen-Le , Wang Rui , Mou Ling-Yun 
Published: June 2023

AbstractThe widespread application of antiandrogen therapies has aroused a significant increase in the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here we identified a cell surface receptor neurokinin-1 (NK1R) as a clinically relevant driver of treatment-related NEPC (tNEPC). NK1R expression increased in prostate cancer patients, particularly higher in metastatic prostate cancer and treatment-related NEPC, implying a relation with the progression from primary luminal adenocarcinoma toward NEPC. High NK1R level was clinically correlated with accelerated tumor recurrence and poor survival. Mechanical studies identified a regulatory element in the NK1R gene transcription ending region that was recognized by AR. AR inhibition enhanced the expression of NK1R, which mediated the PKCα-AURKA/N-Myc pathway in prostate cancer cells. Functional assays demonstrated that activation of NK1R promoted the NE transdifferentiation, cell proliferation, invasion, and enzalutamide resistance in prostate cancer cells. Targeting NK1R abrogated the NE transdifferentiation process and tumorigenicity in vitro and in vivo. These findings collectively characterized the role of NK1R in tNEPC progression and suggested NK1R as a potential therapeutic target.
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner
Authors: Zeng Yi , Ma Gang , Cai Fenglin , Wang Pengliang , Liang Han , Zhang Rupeng , Deng Jingyu , Liu Yong 
Published: June 2023

AbstractProtein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner have been well described in previous reports. Besides H3K4me3, H4K20me3 is another catalytic product of SMYD3, however it is a transcriptionally repressive hallmark. Since it is not clear that how SMYD3-elicited transcriptionally repressive program functions in cancer, we used gastric cancer (GC) as a model to investigate the roles of SMYD3-H4K20me3. Herein, online bioinformatics tools, quantitative PCR, western blotting and immunohistochemistry assays demonstrated that SMYD3 expression was markedly increased in GC tissues from our institutional and The Cancer Genome Atlas (TCGA) cohort. Additionally, aberrantly increased SMYD3 expression was closely associated with aggressive clinical characteristics and poor prognosis. Depletion of endogenous SMYD3 expression using shRNAs significantly attenuates the proliferation in GC cells and Akt signaling pathway in vitro and in vivo. Mechanistically, chromatin immunoprecipitation (ChIP) assay showed that SMYD3 epigenetically repressed the expression of epithelial membrane protein 1 (EMP1) in an H4K20me3-dependent manner. Gain-of-function and rescue experiments validated that EMP1 inhibited the propagation of GC cells and reduced p-Akt (S473) level. Based on these data, pharmaceutical inhibition of SMYD3 activity using the small inhibitor BCI-121 deactivated Akt signaling pathway in GC cells and further impaired the cellular viability in vitro and in vivo. Together, these results demonstrate that SMYD3 promotes the proliferation in GC cells and may be a valid target for therapeutic intervention of patients with GC.
High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction
Authors: Qu Minli , Zuo Linhui , Zhang Mengru , Cheng Peng , Guo Zhanjun , Yang Junya , Li Changjun , Wu Jing 
Published: June 2023

AbstractTau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N6-methyladenosine (m6A) methylation is the most common modification of eukaryotic mRNA and is involved in regulating diverse biological processes. However, the role of m6A alteration in tau hyperphosphorylation of hippocampus neurons has not been reported. We found lower ALKBH5 expression in the hippocampus of diabetic rats and in HN-h cells with high-glucose intervention, accompanied by tau hyperphosphorylation. ALKBH5 overexpression significantly reversed tau hyperphosphorylation in high-glucose-stimulated HN-h cells. Furthermore, we found and confirmed by m6A–mRNA epitope transcriptome microarray and transcriptome RNA sequencing coupled with methylated RNA immunoprecipitation that ALKBH5 regulates the m6A modification of Dgkh mRNA. High glucose inhibited the demethylation modification of Dgkh by ALKBH5, resulting in decreases in Dgkh mRNA and protein levels. Overexpression of Dgkh reversed tau hyperphosphorylation in HN-h cells after high-glucose stimulation. Overexpression of Dgkh by adenovirus suspension injection into the bilateral hippocampus of diabetic rats significantly ameliorated tau hyperphosphorylation and diabetic cognitive dysfunction. In addition, ALKBH5 targeted Dgkh to activate PKC-α, leading to tau hyperphosphorylation under high-glucose conditions. The results of this study reveal that high glucose suppresses the demethylation modification of Dgkh by ALKBH5, which downregulates Dgkh and leads to tau hyperphosphorylation through activation of PKC-α in hippocampal neurons. These findings may indicate a new mechanism and a novel therapeutic target for diabetic cognitive dysfunction.
Immunoception: the insular cortex perspective
Authors: Rolls Asya 
Published: June 2023

AbstractTo define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC).
Ferromagnetism emerged from non-ferromagnetic atomic crystals
Authors: Gong Cheng , Zhang Peiyao , Norden Tenzin , Li Quanwei , Guo Zhen , Chaturvedi Apoorva , Najafi Arman , Lan Shoufeng , Liu Xiaoze , Wang Yuan , Gong Shi-Jing , Zeng Hao , Zhang Hua , Petrou Athos , Zhang Xiang 
Published: June 2023

AbstractThe recently emerged ferromagnetic two-dimensional (2D) materials provide unique platforms for compact spintronic devices down to the atomic-thin regime; however, the prospect is hindered by the limited number of ferromagnetic 2D materials discovered with limited choices of magnetic properties. If 2D antiferromagnetism could be converted to 2D ferromagnetism, the range of 2D magnets and their potential applications would be significantly broadened. Here, we discovered emergent ferromagnetism by interfacing non-magnetic WS2 layers with the antiferromagnetic FePS3. The WS2 exhibits an order of magnitude enhanced Zeeman effect with a saturated interfacial exchange field ~38 Tesla. Given the pristine FePS3 is an intralayer antiferromagnet, the prominent interfacial exchange field suggests the formation of ferromagnetic FePS3 at interface. Furthermore, the enhanced Zeeman effect in WS2 is found to exhibit a strong WS2-thickness dependence, highlighting the layer-tailorable interfacial exchange coupling in WS2-FePS3 heterostructures, which is potentially attributed to the thickness-dependent interfacial hybridization.
Importance of subsurface water for hydrological response during storms in a post-wildfire bedrock landscape
Authors: Atwood Abra , Hille Madeline , Clark Marin Kristen , Rengers Francis , Ntarlagiannis Dimitrios , Townsend Kirk , West A. Joshua 
Published: June 2023

AbstractWildfire alters the hydrologic cycle, with important implications for water supply and hazards including flooding and debris flows. In this study we use a combination of electrical resistivity and stable water isotope analyses to investigate the hydrologic response during storms in three catchments: one unburned and two burned during the 2020 Bobcat Fire in the San Gabriel Mountains, California, USA. Electrical resistivity imaging shows that in the burned catchments, rainfall infiltrated into the weathered bedrock and persisted. Stormflow isotope data indicate that the amount of mixing of surface and subsurface water during storms was similar in all catchments, despite higher streamflow post-fire. Therefore, both surface runoff and infiltration likely increased in tandem. These results suggest that the hydrologic response to storms in post-fire environments is dynamic and involves more surface-subsurface exchange than previously conceptualized, which has important implications for vegetation regrowth and post-fire landslide hazards for years following wildfire.
Spin current driven by ultrafast magnetization of FeRh
Authors: Kang Kyuhwe , Omura Hiroki , Yesudas Daniel , Lee OukJae , Lee Kyung-Jin , Lee Hyun-Woo , Taniyama Tomoyasu , Choi Gyung-Min 
Published: June 2023

AbstractLaser-induced ultrafast demagnetization is an important phenomenon that probes arguably the ultimate limits of the angular momentum dynamics in solid. Unfortunately, many aspects of the dynamics remain unclear except that the demagnetization transfers the angular momentum eventually to the lattice. In particular, the role and origin of electron-carried spin currents in the demagnetization process are debated. Here we experimentally probe the spin current in the opposite phenomenon, i.e., laser-induced ultrafast magnetization of FeRh, where the laser pump pulse initiates the angular momentum build-up rather than its dissipation. Using the time-resolved magneto-optical Kerr effect, we directly measure the ultrafast-magnetization-driven spin current in a FeRh/Cu heterostructure. A strong correlation between the spin current and the magnetization dynamics of FeRh is found even though the spin filter effect is negligible in this opposite process. This result implies that the angular momentum build-up is achieved by an angular momentum transfer from the electron bath (supplier) to the magnon bath (receiver) and followed by the spatial transport of angular momentum (spin current) and dissipation of angular momentum to the phonon bath (spin relaxation).
Cell facilitation promotes growth and survival under drug pressure in breast cancer
Authors: Emond Rena , Griffiths Jason I. , Grolmusz Vince Kornél , Nath Aritro , Chen Jinfeng , Medina Eric F. , Sousa Rachel S. , Synold Timothy , Adler Frederick R. , Bild Andrea H. 
Published: June 2023

AbstractThe interplay of positive and negative interactions between drug-sensitive and resistant cells influences the effectiveness of treatment in heterogeneous cancer cell populations. Here, we study interactions between estrogen receptor-positive breast cancer cell lineages that are sensitive and resistant to ribociclib-induced cyclin-dependent kinase 4 and 6 (CDK4/6) inhibition. In mono- and coculture, we find that sensitive cells grow and compete more effectively in the absence of treatment. During treatment with ribociclib, sensitive cells survive and proliferate better when grown together with resistant cells than when grown in monoculture, termed facilitation in ecology. Molecular, protein, and genomic analyses show that resistant cells increase metabolism and production of estradiol, a highly active estrogen metabolite, and increase estrogen signaling in sensitive cells to promote facilitation in coculture. Adding estradiol in monoculture provides sensitive cells with increased resistance to therapy and cancels facilitation in coculture. Under partial inhibition of estrogen signaling through low-dose endocrine therapy, estradiol supplied by resistant cells facilitates sensitive cell growth. However, a more complete blockade of estrogen signaling, through higher-dose endocrine therapy, diminished the facilitative growth of sensitive cells. Mathematical modeling quantifies the strength of competition and facilitation during CDK4/6 inhibition and predicts that blocking facilitation has the potential to control both resistant and sensitive cancer cell populations and inhibit the emergence of a refractory population during cell cycle therapy.
Predictive neural representations of naturalistic dynamic input
Authors: de Vries Ingmar E. J. , Wurm Moritz F. 
Published: June 2023

AbstractAdaptive behavior such as social interaction requires our brain to predict unfolding external dynamics. While theories assume such dynamic prediction, empirical evidence is limited to static snapshots and indirect consequences of predictions. We present a dynamic extension to representational similarity analysis that uses temporally variable models to capture neural representations of unfolding events. We applied this approach to source-reconstructed magnetoencephalography (MEG) data of healthy human subjects and demonstrate both lagged and predictive neural representations of observed actions. Predictive representations exhibit a hierarchical pattern, such that high-level abstract stimulus features are predicted earlier in time, while low-level visual features are predicted closer in time to the actual sensory input. By quantifying the temporal forecast window of the brain, this approach allows investigating predictive processing of our dynamic world. It can be applied to other naturalistic stimuli (e.g., film, soundscapes, music, motor planning/execution, social interaction) and any biosignal with high temporal resolution.
A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors
Authors: Tong Xin , Zhao Jia-Jia , Feng Ya-Lan , Zou Jing-Ze , Ye Jian , Liu Junfeng , Han Chenggui , Li Dawei , Wang Xian-Bing 
Published: June 2023

AbstractSelective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation.