bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaposiform lymphangiomatosis: Diagnosis, pathogenesis, and treatment
Authors: McDaniel C. Griffin , Adams Denise M. , Steele Kimberley E. , Hammill Adrienne M. , Merrow A. Carl , Crane Janet L. , Smith Christopher L. , Kozakewich Harry P. W. , Le Cras Timothy D. 
Published: January 2023

AbstractKaposiform lymphangiomatosis (KLA) is a life‐threatening rare disease that can cause substantial morbidity, mortality, and social burdens for patients and their families. Diagnosis often occurs long after initial symptoms, and there are few centers in the world with the expertise to diagnose and care for patients with the disease. KLA is a lymphatic anomaly and significant advancements have been made in understanding its pathogenesis and etiology since its first description in 2014. This review provides multidisciplinary, comprehensive, and state‐of‐the‐art information on KLA patient presentation, diagnostic imaging, pathology, organ involvement, genetics, and pathogenesis. Finally, we describe current therapeutic approaches, important areas for research, and challenges faced by patients and their families. Further insights into the pathogenesis of KLA may advance our understanding of other vascular anomalies given that similar signaling pathways may be involved.
Prenatal diagnosis of vascular anomalies
Authors: Agarwal Shreya , Mehollin‐Ray Amy , Sutton Vernon R. , Iacobas Ionela 
Published: January 2023

AbstractVascular anomalies are rare disorders that encompass a group of lesions characterized by abnormal development of the lymphovascular system. Majority of these anomalies are present at birth and could potentially be detected during the prenatal period on imaging. This allows for early intervention and prompt management to improve outcomes. However, they can be difficult to diagnose, given the rarity and overlapping findings. In this review article, we provide a comprehensive overview of congenital vascular anomalies with a liberal use of images of recent cases at our center emphasizing prenatal imaging findings and the natural history of these conditions.
Quantitative transcriptomic and proteomic analyses reveal the potential maintenance mechanism of female adult reproductive diapause in Chrysoperla nipponensis
Authors: Chen Zhen‐Zhen , Wang Xiao , Kong Xue , Zhao Yue‐Ming , Xu Ming‐Hui , Gao Yu‐Qing , Huang Hai‐Yi , Liu Fang‐Hua , Wang Su , Xu Yong‐Yu , Kang Zhi‐Wei 
Published: January 2023

AbstractBACKGROUNDThe green lacewing Chrysoperla nipponensis is an important natural enemy of many insect pests and exhibits reproductive diapause to overwinter. Our previous studies showed that adult C. nipponensis enters reproductive diapause under a short‐day photoperiod. However, the molecular mechanism underlying diapause maintenance in C. nipponensis is still unknown.RESULTSThe total lipid and triglyceride content showed the reservation and degradation of energy during diapause in C. nipponensis. Thus, we performed combined transcriptomic and proteomic analyses of female reproductive diapause in C. nipponensis at three ecophysiological phases (initiation, maintenance and termination). A total of 64 388 unigenes and 5532 proteins were identified from the transcriptome and proteome. In‐depth dissection of the gene‐expression dynamics revealed that differentially expressed genes and proteins were predominately involved in the lipid and carbohydrate metabolic pathways, in particular fatty acid metabolism, metabolic pathways and the citrate cycle. Among of these genes, TIM, CLK, JHAMT2, PMK, HMGS, HMGR, FKBP39, Kr‐h1, Phm, ECR, IR1, ILP3, ILP4, mTOR, ACC, LSD1 and LSD2 were differentially expressed in diapause and non‐diapause female adults of C. nipponensis. The expression patterns of these genes were consistent with the occurrence of vitellogenesis and expression of either Vg or VgR.CONCLUSIONOur findings indicated that diapause adult C. nipponensis accumulate energy resources to overwinter. Transcriptomic and proteomic analyses suggested candidate key genes involved in the maintenance of C. nipponensis during adult reproductive diapause. Taken together, these results provide in‐depth knowledge to understand the maintenance mechanism of C. nipponensis during adult reproductive diapause. © 2023 Society of Chemical Industry.
The changing characteristics of rainfall over the Brahmaputra Basin during 1998–2018
Authors: Gogoi Partha Pratim , Vinoj V. , Landu Kiranmayi , Phukon Parag 
Published: January 2023

AbstractThe changes to the hydrological cycle as a consequence of climate change significantly affect the water security of countries worldwide. The Brahmaputra Basin (BB), a biodiversity hotspot, is among the world's wettest regions and is vulnerable to climate change. Using ground and satellite‐based datasets from multiple sources and a percentile‐based analysis from 1998 to 2018, it is found that an asymmetric trend exists in extreme rainfall over the hills and the adjacent plains of the basin. The hills experience a decline in rainfall, whereas, over the plains, an increase is observed on similar rainfall days. During 1998–2018, mean accumulated rainfall over the whole basin declined by as much as ∼60% during the October to December (OND) period. Similarly, a decline of ∼20% is observed for June to September (JJAS). The most significant reduction in mean rainfall was mainly over the wettest regions of the basin, such as Cherrapunji/Mawsynram and is concentrated in the highest percentile (extreme events) of rainfall distribution. Such an overall decline in total rainfall coupled with altitudinal asymmetry in percentile distributions of rainfall may contribute towards flood hazards with changing lead time for warning, posing severe socio‐economic challenges.
Task bottlenecks and resource bottlenecks: A holistic examination of task systems through an organization design lens
Authors: Karim Samina , Lee Chi‐Hyon , Hoehn‐Weiss Manuela N. 
Published: January 2023

AbstractResearch SummaryUsing an organization design lens, we explore how key characteristics of both task systems and their associated resources may benefit firms. We unpack task system interdependencies by studying the interaction of decentralization and complexity, examining resource fungibility and resource slack, and exploring their joint alignment. Our context is the scheduled U.S. passenger airline industry over two decades. Results show that firm performance improves when (a) task system decentralization and complexity are aligned, either more or less of both; (b) having both resource fungibility and resource slack, not simply more of one or the other; and (c) aligning less decentralized and less complex task systems with fungible and available resources. Our findings underscore the importance of holistically managing tasks and resources to minimize bottlenecks within organizations.Managerial SummaryEliminating bottlenecks can help firms improve performance. Our study focuses on two types of bottlenecks—task system bottlenecks stemming from the design of activities and resource bottlenecks, created when necessary resources are already in use or available resources are not applicable. Our results show that firms benefit when task system properties of decentralization and complexity are aligned and when firms' resources are both fungible and available; these characteristics also reinforce each other. Thus, managers should be aware of both task system properties and resource characteristics to avoid bottlenecks, so that the tasks to which the resources are applied can be completed. In addition, managers should ensure to have available and fungible resources at their disposal, especially when organizations have a centralized and less complex design.
The Synergy of Hydrogen Bond and Entanglement of Elastomer Captures Unprecedented Flaw Insensitivity Rate
Authors: Zeng Xiangliang , Xu Lu , Xia Xinnian , Bai Xue , Zhong Cheng , Fan Jianfeng , Ren Linlin , Sun Rong , Zeng Xiaoliang 
Published: January 2023

AbstractElastomers are regarded as one of the best candidates for the matrix material of soft electronics, yet they are susceptible to fracture due to the inevitable flaws generated during applications. Introducing microstructures, sacrificial bonds, and sliding cross‐linking has been recognized as an effective way to improve the flaw insensitivity rate (Rinsen). However, these elastomers still prone to failure under tensile loads with the presence of even small flaws. Here, this work reports a polybutadiene elastomer with unprecedented Rinsen via the synergy of hydrogen bond and entanglement. The resulting polybutadiene elastomer exhibits a Rinsen ≈1.075, which is much higher than those of reported elastomers. By molecular chain interaction and molecular chain conformation analysis, this work demonstrates that the synergistic effect of hydrogen bond dissociation and entanglement slip in the polybutadiene elastomers during stretching leads to the high Rinsen. Using polybutadiene elastomer as matrix of thermal interface materials, this work demonstrates effective heat transfer for strain sensor and electronic devices. In addition, cytocompatibility of the elastomers is verified by cell proliferation and live/dead viability assays. The combination of outstanding biocompatible and excellent mechanical properties of the elastomers creates new opportunities for their applications in electronic skin.
Bi‐MOF Modulating MnO2 Deposition Enables Ultra‐Stable Cathode‐Free Aqueous Zinc‐Ion Batteries
Authors: Gou Lei , Li Junru , Liang Kai , Zhao Shaopan , Li Donglin , Fan Xiaoyong 
Published: January 2023

AbstractThe Mn‐based materials are considered as the most promising cathodes for zinc‐ion batteries (ZIBs) due to their inherent advantages of safety, sustainability and high energy density, however suffer from poor cyclability caused by gradual Mn2+ dissolution and irreversible structural transformation. The mainstream solution is pre‐adding Mn2+ into the electrolyte, nevertheless faces the challenge of irreversible Mn2+ consumption results from the MnO2 electrodeposition reaction (Mn2+ → MnO2). This work proposes a “MOFs as the electrodeposition surface” strategy, rather than blocking it. The bismuth (III) pyridine‐3,5‐dicarboxylate (Bi‐PYDC) is selected as the typical electrodeposition surface to regulate the deposition reaction from Mn2+ to MnO2. Because of the unique less hydrophilic and manganophilic nature of Bi‐PYDC for Mn2+, a moderate MnO2 deposition rate is achieved, preventing the electrolyte from rapidly exhausting Mn2+. Simultaneously, the intrinsic stability of deposited R‐MnO2 is enhanced by the slowly released Bi3+ from Bi‐PYDC reservoir. Furthermore, Bi‐PYDC shows the ability to accommodate H+ insertion/extraction. Benefiting from these merits, the cathode‐free ZIB using Bi‐PYDC as the electrodeposition surface for MnO2 shows an outstanding cycle lifespan of more than 10 000 cycles at 1 mA cm‐2. This electrode design may stimulate a new pathway for developing cathode free long‐life rechargeable ZIBs.
Bioenergetics model for the nonnative Redside Shiner
Authors: Johnson Rachelle C. , Beauchamp David A. , Olden Julian D. 
Published: January 2023

Abstract

Objective
Redside Shiner Richardsonius balteatus has expanded from its native range in the Pacific Northwest region of North America to establish populations in six other western states. This expansion has fueled concerns regarding competition between Redside Shiner and native species, including salmonids. We developed a bioenergetic model for Redside Shiner, providing a powerful tool to quantify its trophic role in invaded ecosystems and evaluate potential impacts on native species.

Methods
Mass- and temperature-dependent functions for consumption and respiration were fit based on controlled laboratory experiments of maximum consumption rates and routine metabolic rates using intermittent-flow respirometry, across a range of fish sizes (0.6–27.3 g) and temperatures (5–31°C). Laboratory growth experiments were conducted to corroborate model performance across different temperatures and feeding rates.

Result
Initial bioenergetic simulations of long-term growth experiments indicated large model error for predicted consumption and growth, and deviations from observed responses varied systematically as a function of daily consumption rate (J·g−1·d−1) and water temperature. A growth rate error correction function was developed and included in the bioenergetics model framework on a daily time step, resulting in decreased absolute model error in all experimental groups. Predicted values from the corrected model were highly correlated with observed values (R2; consumption = 0.97, final weight = 0.99) and unbiased. These results show that the optimal temperature for Redside Shiner growth (18°C) exceeds that of Pacific salmon Oncorhynchus spp. by 2–6°C under a scenario of high food availability and moderate food quality.

Conclusion
Consequently, increases in water temperature associated with climate change may favor growth and expansion of Redside Shiner populations, while negatively affecting some salmonids. The bioenergetics model presented here provides the necessary first step in quantifying trophic impacts in sensitive ecosystems where Redside Shiner have invaded or in ecosystems where anadromous salmonid reintroductions are being considered.
Data Justice, Computational Social Science and Policy
Authors: Taylor Linnet 
Published: January 2023

AbstractBig data has increased attention to Computational Social Science (CSS) on the part of policymakers because it has the power to make populations, activities and behaviour visible in ways that were not previously possible. This kind of analysis, however, often has unforeseen implications for those who are the subjects of the research. This chapter asks what a social justice perspective can tell us about the potential, and the risks, of this kind of analysis when it is oriented towards informing policy. Who benefits, and how, when computational methods and new data sources are used to conduct policy-relevant analysis? Should CSS sidestep, through its novelty and its identification with computational and statistical methodologies, sidestep ethical review and the assessments of power asymmetries and methodological justification that are common in social science research? If not, how should these be applied to CSS research, and what kind of assessment is appropriate? The analysis offers two main conclusions: first, that the field of CSS has evolved without an accompanying evolution of debates on ethics and justice and that these debates are long overdue. Second, that CSS is privileged as policy-relevant research precisely because of many of the features which bring up concerns about justice—large-scale datasets, remote data gathering, purely quantitative methods and an orientation towards policy questions rather than the needs of the research subjects.
Cooperative human–robot polishing for the task of patina growing on high-quality leather shoes
Authors: Borrell Jorge , González Alejandra , Perez-Vidal Carlos , Gracia Luis , Solanes J. Ernesto 
Published: January 2023

Abstract
A patina is essentially the weathered look a piece of leather takes on as it ages. The patina finishing aspect can be also generated or grown artificially by scrubbing the leather surface with specific products. These kinds of manual finishing operations on small objects are delicate and regularly need slight corrections carried out by skilled artisans, which adds complexity to the process automation and implies various key aspects to consider. This research presents a novel approach for automatic and semiautomatic shoe patina growing in the footwear industry using a new co-creative method based on cooperative robotics. The system automates the process in pursuit of operator time-saving without reducing the work finishing quality. For this purpose, the use of a collaborative robot with a built-in constant contact force control and a collaborative tool are used in this research. The use of both tools in complementarity with the knowledge of the craftsman leads the robot end-effector adaptation to the inherent curved surfaces over the shoe. Besides, some orientation corrections are applied based on the CAD model for the task to be accurately accomplished. The solution has been successfully integrated in a real production line, and it is currently in use.
A comparison of simplified protocols of personalized dosimetry in NEN patients treated by radioligand therapy (RLT) with [177Lu]Lu-DOTATATE to favor its use in clinical practice
Authors: Pirozzi Palmese Valentina , D’Ambrosio Laura , Di Gennaro Francesca , Maisto Costantina , de Marino Roberta , Morisco Anna , Coluccia Sergio , Di Gennaro Piergiacomo , De Lauro Francesco , Raddi Marco , Gaballo Paolo , Tafuto Salvatore , Celentano Egidio , Lastoria Secondo 
Published: January 2023

Abstract

The role of internal dosimetry is usually proposed for investigational purposes in patients treated by RLT, even if its application is not yet the standard method in clinical practice. This limited use is partially justified by several concomitant factors that make calculations a complex process. Therefore, simplified dosimetry protocols are required.

Methods
In our study, dosimetric evaluations were performed in thirty patients with NENs who underwent RLT with [177Lu]Lu-DOTATATE. The reference method (M0) calculated the cumulative absorbed dose performing dosimetry after each of the four cycles. Obtained data were employed to assess the feasibility of simplified protocols: defining the dosimetry only after the first cycle (M1) and after the first and last one (M2).

Results
The mean differences of the cumulative absorbed doses between M1 and M0 were – 10% for kidney, – 5% for spleen, + 34% for liver, + 13% for red marrow, and + 37% for tumor lesions. Conversely, differences lower than ± 10% were measured between M2 and M0.

Conclusion
Cumulative absorbed doses obtained with the M2 protocol resembled the doses calculated by M0, while the M1 protocol overestimated the absorbed doses in all organs at risk, except for the spleen.
Prognostic Impact of Main Lymph Node Metastasis in Patients with Colon Cancer
Authors: Sugiura Kiyoaki , Seo Yuki , Tajima Yuki , Kikuchi Hiroto , Hirata Akira , Nakadai Jumpei , Baba Hideo , Kondo Takayuki , Makino Akitsugu , Kato Yujin , Matsui Shimpei , Seishima Ryo , Shigeta Kohei , Okabayashi Koji , Kitagawa Yuko 
Published: January 2023

AbstractBackgroundAlthough extended lymph node dissection during colon cancer surgery is recommended in both Western and Eastern countries, the perception and clinical significance of main lymph node metastasis (MLNM) remains controversial.MethodsIn total, 1557 patients with colon cancer who underwent curative resection with D3 dissection were retrospectively analyzed. Clinicopathological factors associated with MLNM were analyzed. Kaplan–Meier survival analysis and log‐rank tests were used to compare the prognosis between the MLNM and non‐MLNM groups.ResultsMultivariate analysis showed that overall survival (OS) [hazard ratio, 2.117 (0.939–4.774), p = 0.071] and recurrence‐free survival (RFS) [hazard ratio, 2.183 (1.182–4.031), p = 0.013] were affected by the MLNM status independent of the TNM stage. Survival analysis demonstrated that among patients with stage III disease, the OS and RFS rates were significantly different between patients with and without MLNM (OS: p = 0.0147, RFS: p = 0.0001). However, the OS and RFS rates were not significantly different between patients who had stage III disease with MLNM and patients who had stage IV disease (OS: p = 0.5901, RFS: p = 0.9610).ConclusionsMLNM is an independent prognostic factor for patients with colon cancer. The addition of the MLNM status to the current TNM classification may enhance the prognostic value of the TNM staging system and the clinical efficacy of adjuvant therapy in patients with colon cancer.
Two-stage stochastic formulation for relief operations with multiple agencies in simultaneous disasters
Authors: Rodríguez-Espíndola Oscar 
Published: January 2023

AbstractThe increasing damage caused by disasters is a major challenge for disaster management authorities, especially in instances where simultaneous disasters affect different geographical areas. The uncertainty and chaotic conditions caused by these situations combined with the inherent complexity of collaboration between multiple stakeholders complicates delivering support for disaster victims. Decisions related to facility location, procurement, stock prepositioning and relief distribution are essential to ensure the provision of relief for these victims. There is a need to provide analytical models that can support integrated decision-making in settings with uncertainty caused by simultaneous disasters. However, there are no formulations tackling these decisions combining multiple suppliers, multiple agencies, and simultaneous disasters. This article introduces a novel bi-objective two-stage stochastic formulation for disaster preparedness and immediate response considering the interaction of multiple stakeholders in uncertain environments caused by the occurrence of simultaneous disasters. At the first stage, decisions related to the selection of suppliers, critical facilities, agencies involved, and pre-disaster procurement are defined. Resource allocation, relief distribution and procurement of extra resources after the events are decided at the second stage. The model was tested on data from the situation caused by simultaneous hurricanes and storms in Mexico during September of 2013. The case is contrasted with instances planning for disasters independently. The results show how planning for multiple disasters can help understand the real boundaries of the disaster response system, the benefits of integrated decision-making, the impact of deploying only the agencies required, and the criticality of considering human resources in disaster planning.
Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
Authors: Gallo-Villegas Jaime A. , Calderón Juan C. 
Published: January 2023

AbstractGiven their importance in predicting clinical outcomes, cardiorespiratory fitness (CRF) and muscle status can be considered new vital signs. However, they are not routinely evaluated in healthcare settings. Here, we present a comprehensive review of the epidemiological, mechanistic, and practical bases of the evaluation of CRF and muscle status in adults in primary healthcare settings. We highlight the importance of CRF and muscle status as predictors of morbidity and mortality, focusing on their association with cardiovascular and metabolic outcomes. Notably, adults in the best quartile of CRF and muscle status have as low as one-fourth the risk of developing some of the most common chronic metabolic and cardiovascular diseases than those in the poorest quartile. The physiological mechanisms that underlie these epidemiological associations are addressed. These mechanisms include the fact that both CRF and muscle status reflect an integrative response to the body function. Indeed, muscle plays an active role in the development of many diseases by regulating the body’s metabolic rate and releasing myokines, which modulate metabolic and cardiovascular functions. We also go over the most relevant techniques for assessing peak oxygen uptake as a surrogate of CRF and muscle strength, mass, and quality as surrogates of muscle status in adults. Finally, a clinical case of a middle-aged adult is discussed to integrate and summarize the practical aspects of the information presented throughout. Their clinical importance, the ease with which we can assess CRF and muscle status using affordable techniques, and the availability of reference values, justify their routine evaluation in adults across primary healthcare settings.