bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognizance and Perception of Physiotherapy Intervention in Attention- Deficit/Hyperactivity Disorder Amongst Clinical Physiotherapy Students in Tertiary Institution, Nigeria
Authors: Okonkwo Uchenna Prosper , Nwose Joy Chinazaekpere , Akosile Christopher Olusanja , Chukwuemeka Uchechukwu Martha , Mbanuzuru Ahaoma Victor , Igwe Emeka Sylvester , Okafor Christiana Nkiru , Ummunah Joseph Onuuwa 
Published: February 2023

Abstract
Objectives: This study examines cognizance and perception of physiotherapy intervention in ADHD amongst clinical physiotherapy students in a tertiary institution and, also, determines the relationship of the study variables on the socio-demographic characteristics.
Methods: This study is a cross-sectional survey and employed a convenient sampling technique to recruit 137 respondents. A cognizance and perception questionnaire was used as the survey instrument to obtain data. Descriptive statistics of frequency, mean and standard deviation were used to analyze the socio-demographic characteristic. Spearman rank correlation was used to analyze the relationship amongst the variables of COG-ADHD, PERCEP-ADHD, COG-PT_ITV, PERCEP-PT_ITV, Mann-Whitney U test was used to test the influence of socio-demographic characteristics of age and the level of study on the cognizance and perception of ADHD. Variables having a p-value < 0.05 were considered statistically significant.
Result: The majority of the respondents (63.5%) had high cognizance of physiotherapy intervention for ADHD, while, the majority of the respondents (60.6%) had a fair perception of physiotherapy intervention for ADHD. A significant proportion of respondents (26.3%) had no source of information on ADHD before the study. Cognizance of ADHD significantly correlated with perception of ADHD, ADHD, and perception of physiotherapy intervention in ADHD, and cognizance of physiotherapy intervention in ADHD. There were significant positive correlations between gender and cognizance of physiotherapy intervention in ADHD, and between the level of study and perception of ADHD
Conclusion: Respondents' perception of physiotherapy intervention in ADHD was relatively low; in contrast, their cognizance was relatively satisfactory. Strengthening their cognizance and perception is paramount.
Effects of local and systemic metronidazole as adjunctive treatment in chronic periodontitis patients
Authors: Barrouz Maryam Mehravani , Houshyar Ehsan , Jamalnia Sheida , Ghareaghaji Rasul 
Published: February 2023

Abstract

Aim
This study aimed to compare the effects of local and systemic metronidazole in patients with chronic periodontitis.
Materials and methods
In this randomized clinical study, 30 patients (3 teeth per patient) were treated in three groups: SRP treatment alone, metronidazole tablet as adjunctive treatment, and metronidazole gel as adjunctive treatment. BOP (Bleeding on probing), PPD (pocket probing depth), and CAL (clinical attachment level) data were taken at the beginning and three months later. Collected data tested by Wilcoxon test and Kruskal-Wallis. Statistical analysis was performed using SPSS V.21.
Results
BOP, CAL, and PPD levels were significantly different at the beginning of treatment and after three months, and this was true for all treatments. BOP, CAL, and PPD levels did not differ significantly between the three groups after the treatment. (p > 0.005).
Conclusion
The effectiveness of these methods was all equal. Accordingly, choosing one of these methods depends on the ease of use, the patient's condition, and the clinician’s opinion.
Clinical relevance:
Chronic Periodontitis is progressive disease wich can cause tooth loss. The accepted treatment is scaling and root planing (SRP). Antibiotics used systemically can penetrate the depth of the periodontal pockets but have several side effects; Hence, using a kind of less complicated medicinal form in the form of a topical gel as an adjunctive therapy in the treatment of chronic periodontitis can be more effective.
Effects of Mindfulness and Holotropic Breathwork on the Rehabilitation of Adolescents Who Use Psychoactive Substances: A Pilot Study
Authors: Sánchez-Quijano Frank , Puerta-Cortés Diana Ximena , Mazorco-Salas Julio Eduardo 
Published: February 2023

Abstract
This pilot study aims to compare the effects of mindfulness and holotropic breathwork treatments on adolescents in the rehabilitation process for psychoactive substance use. Participants comprised 18 female adolescents aged 15–18 admitted to the Fundación Grupo de Apoyo, affiliated with the Colombian Family Welfare Institute. The Fundación is dedicated to rehabilitation from, detoxification from, and prevention of psychoactive substance use. The study utilizes a mixed methods approach with an exploratory design. Heart rate is used as an important indicator of psychological well-being and overall cardiovascular health, and the mean pretest/posttest heart rates of the control and experimental groups are compared quantitatively. The effects of both treatments on the study population are described qualitatively. The results show a reduction in heart rate in the mindfulness group compared to the control. The narratives of the participants and the institution’s workers show positive changes in emotional regulation and coping, better communication, and a reduction in stress and anxiety or the desire to use, as a result of both experimental treatments.
The role of outer membrane protein A in OmpA vaccine was revealed by the analysis of alternative splicing and lncRNA after the Edwardsiella anguillarum infected the immunized European eels (Anguilla anguilla)
Authors: Guo Songlin , Chen Minxia , Wan Qijuan , Li Wanbo , Xu Ming 
Published: February 2023

Abstract

Edwardsiella anguillarumis a common bacterial pathogen mainly infected cultivated eel, and outer membrane protein A (OmpA) emulsified with Freund's adjuvant was evaluated as an effective fishery vaccine. However, the role of solo OmpA in the vaccine have not been explored on the molecular mechanism. In this study, we examined the RNA-seq in the liver of European eel (Anguilla anguilla) post the challenge ofE. anguillarumin eels injected with the OmpA vaccine, Freund's adjuvant, or PBS to elucidate the alternative splicing (AS) and long noncoding RNA (lncRNA) in the process ofE. anguillaruminfection and host anti-infection using genome-wide transcriptome. After all eels were challenged byE. anguillarumat 28 d post the injection (dpi), compared to severe pathological changes in the liver of PBS injected eels (Con_inf group), the OmpA immunized eels (OmpA_inf group) showed infiltrated lymphocytes in the liver as well as the Freund's adjuvant inoculated eels (FCIA_inf group) showed slight edema of hepatocytes and blood coagulation. Compared to the Con_inf group, the relative percent survival (RPS) of eels was 77.7% and 44.4% in OmpA_inf and FCIA_inf group. The results of DEGs and DE-transcripts showed 6 samples in the OmpA_inf and FCIA_inf groups were clustered together, which different to 3 samples in the Con_inf group. We found only 35 DEGs between OmpA_inf and FCIA_inf compare to thousands of DEGs in two compares of OmpA_inf vs Con_inf and FCIA_inf Con_inf. GO and KEGG analysis of genes targeted by 37 DE-lncRNAs in co-expression and co-location showed at least 52 GO terms and 2 KEGG pathways were enrichment. The results of AS analysis showed 293 differentially alternative splicing (DAS) genes between OmpA_inf and FCIA_inf were mainly involved in GO terms of catalytic activity, membrane part and biological regulation, and KEGG pathways of signal transduction, immune system and infection disease. Finally, the interaction between proteins expressed by DAS genes and the interaction between DE-lncRNAs and target genes were explored using Cytoscape 3.9.1. The results indicated 66 DAS gene expressed proteins formed total of 50 degrees in 20 networks, and 33 DE-lncRNAs interacted with 194 target genes formed total of 246 and 41 networks in co-expression and co-location. Taken together, after the immunization of OmpA vaccine, compared to Freund's adjuvant inoculation, higher RPS was closely related to DAS genes and DE-lncRNAs in response toE. anguillaruminfection in European eels. The OmpA role in vaccine was firstly revealed through AS genes and lncRNAs, and results of this study are of great significance to the development of fishery subunit vaccines.
Tuned responses to visual short-term memory load in a frontoparietal topographic map hierarchy
Authors: Ackooij Martijn van , Paul Jacob , Helden Joeri van , Hendrikx Evi , Gayet Surya , Stoep Nathan van der , Harvey Ben 
Published: February 2023

Abstract
Visual short-term memory (VSTM), intentionally remembering image features, relies on interacting sensory and executive processes. Sensory processing relies on tuned responses, organized in hierarchical networks of topographic maps. How does the brain distribute responses to task demands across neural populations? We examined neural responses to the number of remembered visual items (VSTM load) using ultra-high field fMRI (7T). We describe neural populations showing tuned responses to VSTM load in an extensive series of topographic maps, hierarchically increasing in VSTM load preferences from posterior sensory to anterior executive areas. These responses are absent when viewing the same stimuli without varying task demands, and appear unrelated to response preferences for visual position and numerosity. These results generalize principles of neural tuning, topographic organization, and hierarchical transformations from sensory encoding to distribution of task demands across neural populations.
Clinical-Radiomics Nomogram for Risk Prediction of Esophageal Fistula in Patients with Esophageal Squamous Cell Carcinoma Treated by IMRT or VMAT
Authors: Li Zhaohui , Gong Jie , Shi Liu , Li Jie , Yang Zhi , Chai Guangjin , Lyu Bo , Xiang Geng , Wang Bin , Shi Mei , Zhao Yilin , Zhao Lina 
Published: February 2023

Abstract
Background and purpose: To analyze the predictive factors and establish a prediction model of esophageal fistula (EF) in patients with esophageal squamous cell carcinoma (ESCC) received intensity-modulated radiotherapy (IMRT) or Volumetric Modulated Arc Therapy (VMAT).
Materials and Methods: Patients with ESCC treated with IMRT or VMAT from 2013 to 2020 in Xijing hospital were retrospectively analyzed. 43 patients with EF and 129 patients without EF were included in the analysis by 1:3 propensity score matching (time of diagnosis, gender). The clinical characters and radiomic features were recorded and extracted. Univariate and multivariate stepwise logistic regression analyses were provided to determine the risk factors associated with EF.
Results: The median follow-up time was 23.96 months (range 1.3-104.9 m), and the median OS of EF patients was 13.1 months. 1158 radiomics features were extracted and 8 radiomics features were selected. The area under the receiver operating characteristic curve (AUC) value of radiomic signature calculated by selected features for predicting EF was 0.794. Multivariate analysis showed that the tumor length, tumor volume, T stage, lymphocyte rate and grade 4 esophagus stenosis were related to EF, and the AUC value of clinical nomogram for predicting EF was 0.849. The clinical-radiomics nomogram had the best performance in predicting EF with an AUC value of 0.896.
Conclusions: The clinical-radiomics nomogram can predict the risk of EF in ESCC patients and be helpful for individualized treatment of esophageal cancer.
Hysteresis, endogenous growth, and monetary policy
Authors: Amador Sebastian 
Published: February 2023

Abstract
I provide evidence of substantial hysteresis (i.e., a situation in which temporary shocks have long-run effects) from monetary shocks on two sources of endogenous growth; human capital and technological adoption. This contribution is the first to test for the presence of this phenomenon in direct measures of the supply-side potential of economies, instead of indirect measures, e.g., TFP. To estimate the effects of exogenous monetary policy shocks, I improve on the trilemma identification by incorporating a mean-unbiased instrumental variable estimator. Results show substantial hysteresis in both human capital and technological adoption. Importantly, these are found to be asymmetric, as only contractionary shocks result in long lasting responses. I evaluate the aggregate importance of monetary hysteresis with a growth accounting exercise. Across the 17 countries in sample, the accumulated average cost of monetary hysteresis ranges between 1.2 and 9.6% of TFP, for human capital and the adoption of electricity, respectively.
JEL codes: E32, O40, O47.
Unbalanced segmental duplication of W chromosomes in Australian Ridge-tailed goannas
Authors: Dobry Jason , Zhu Zexian , Zhou Qi , Wapstra Erik , Deakin Janine , Ezaz Tariq 
Published: February 2023

Abstract
Sex chromosomes are mostly conserved, but in some cases are variable within species. Varanids are known for conserved sex chromosomes, but there are differences in the size of the W chromosome among species representing varying stages of sex chromosome evolution. We tested for homology of the ZW sex chromosome system in varanids with size differences among four species from two lineages in Australia, the dwarf lineage Odatria and the sand goanna lineage Gouldii, with a combined genomic and cytogenetic approach. We found that while DNA sequences of the sex chromosomes are conserved, a mutation on an enlarged autosomal microchromosome is homologous with the W in some isolated populations of V. acanthurus and V. citrinus from the Odatria lineage. The enlarged microchromosome was unpaired in all individuals tested and is likely an unbalanced segmental duplication translocated from the W to another microchromosome. We also found evidence of an ancient balanced duplication that is also homologous to the W and to the telomeric region of chromosome 2. We conclude the most parsimonious explanation is that the duplicated region likely originated on chromosome 2. We also demonstrated that genes and related DNA sequences have likely originated on an autosome, translocated to the W, accumulated repeats and amplified on the W and then duplicated and translocated to another autosomal microchromosome. Given the role of these duplications as important evolutionary drivers of speciation in other taxa, our findings provide broader insight into the evolutionary pathway leading to rapid chromosomal and genic divergence of species.
Efficient Parallel Memetic Algorithm to Rule Extraction in Data Mining
Authors: Oualid Dahmri , Baba-Ali Ahmed Riadh 
Published: February 2023

Abstract
This is extension of my last publication [1] with more expermetation to explain how I choseed every variable in each algorithm and to present more clear results and discussions. we presents a parallel memetic algorithm (PMA) for solving the classification problem in the process of Data Mining. We focus our interest on accelerating the PMA. In most parallel algorithms, the tasks performed by different processors need access to shared data, this creates a need for communication, which in turn slows the performance of the PMA. In this work, the design of PMA with new replacement approach is presented.. This latter is a hybrid approach that uses both Lamarckian and Baldwinian approaches at the same time in order to reduce the quantity of information exchanged between processors and consequently to improve the speedup of the proposed algorithm. An extensive experimental study performed on the UCI Benchmarks proves the efficiency of the proposed PMA.
A Comparative Study of Robot-assisted Thoracoscopic Surgery and Video-assisted Thoracoscopic Surgery in Treatment of Pulmonary Sequestration in Children
Authors: Liang Liang , Tan Zheng , Huang Ting , Gao Yue , Zhang Jian , Yu Jiangen , Shu Qiang 
Published: February 2023

Abstract
Purpose
This study was performed to compare the application of robot-assisted thoracoscopic surgery with video-assisted thoracoscopic surgery in the treatment of pulmonary sequestration (PS) in children.
Methods
Clinical data of 128 consecutive pediatric patients undergoing robot-assisted thoracoscopic surgery or video-assisted thoracoscopic surgery for PS from May 2019 to July 2022 at our institution were reviewed. 62 patients underwent robotic-assisted thoracoscopic surgery (RATS group)，while 66 patients underwent video-assisted thoracoscopic surgery (VATS group). There were no significant differences in age, weight, gender, type of PS, preoperative infection and surgical method between the two groups. Aberrant artery was ligated with silk suture or vascular clips and lobectomy, partial lobectomy or sequestrectomy was performed depending on the type of lesion in the two groups. Perioperative outcomes were compared between the two groups to evaluate the efficacy of the RATS.
Results
Neither group had surgical mortality.One case in each group required conversion to thoracotomy (1/62 vs 1/66, P>0.999).The median operation time of the RATS group was 77.5(60.0,111.3) minutes, while the VATS group was 60.0(40.0,75.0)minutes which had a significant difference (P<0.001) between the two groups.However, RATS was associated with less intraoperative bleeding [2.0(1.0, 2.0) ml vs 5.0(2.0, 5.0)ml, P <0.001], shorter postoperative duration [5.0(4.0, 6.0)days vs 6.0(5.0, 7.0)days, P<0.001] and shorter drainage days [1.0(0.8, 1.3)days vs 2.0(1.0, 3.0)days, P<0.001] compared with VATS. No significant difference was found for postoperative complications (hydrothorax and pneumothorax) incidence between two groups.
Conclusion
Although there was limitation of application of RATS in low-age, low-weight infants, RATS was a feasible and safe approach for pediatric patients with PS over 6 months and more than 7kg in weight. Furthermore, due to the enhanced vision and hand-wrist control, RATS had some advantages over VATS with less intraoperative blood loss and shorter postoperative drainage time and hospital duration.
Pan-Cancer Analysis of TASL: A Novel Immune Infiltration-Related Biomarker for Tumor Prognosis and Immunotherapy Response Prediction
Authors: Li Huanyu , Sun Xiaoyu , Zhao Yanyun , Zhang Changzhu , Jiang Kai , Ren Jie , Xing Lijuan , He Miao 
Published: February 2023

Abstract
Background New immunotherapeutic strategies based on predictors are urgently needed. Toll-like receptor adaptor interacting with SLC15A4 on the lysosome (TASL) was recently confirmed to fulfill an important role in the innate immune response. However, whether TASL was involved in tumor immunotherapy response prediction has not been reported.
Methods TCGA and GTEx were used to yield transcriptional, genetic, and epigenetic levels of TASL in 33 cancer types. CIBERSORT was used to explore the correlation between TASL expression and multiple immune-related signatures and tumor-infiltrating immune cell content in different cancer types. The ability of TASL to predict tumor immunotherapy response was analyzed in seven datasets. Finally, we tested TASL expression in human glioma cell lines and tissue samples and analyzed its correlation with clinicopathological parameters.
Results TASL is widely heterogeneous at the transcriptional, genetic, and epigenetic levels. High TASL expression is an independent poor prognostic factor for immune “cold” tumor Low-Grade Glioma (LGG) but an opposite factor for “hot” tumors Lung Adenocarcinoma (LUAD) and Skin Cutaneous Melanoma (SKCM). TASL may affect tumor immune infiltration by mediating tumor-infiltrating lymphocytes and tumor-associated macrophages. It may differentially affect the prognosis of the three cancers by regulating the immunosuppressive microenvironment in LGG and the immunostimulatory microenvironment in LUAD and SKCM. High TASL expression is a potential biomarker for the positive response to immunotherapy in cancers such as SKCM and was also experimentally confirmed to be positively associated with adverse clinicopathological features of gliomas.
Conclusion TASL expression is an independent prognostic factor for LGG, LUAD, and SKCM. High TASL expression is a potential biomarker for the positive response to immunotherapy in certain cancer types. Further basic studies focusing on TASL expression and tumor immunotherapy are urgently needed.
Two novel difference schemes for the one-dimensional multi-term time fractional Oldroyd-B equation
Authors: Guan Zhen 
Published: February 2023

Abstract

In this paper, two novel difference schemes, which are based on the order reduction technique together with the weighted and shifted Grünwald-Letnikov difference (WSGD) operator, are derived for the one-dimensional multi-term time fractional Oldroyd-B equation. Utilizing the discrete energy method, we proved that the schemes are unconditionally stable and convergent in the maximum norm with the global convergence orders O(τ2−β + h2) and O(τ2−β + h4), respectively. Finally, a numerical example is carried out to verify the theoretical results, showing that our schemes are efficient indeed and have higher accuracy compared with the existed methods.
Mathematical formulation and irregularity topological indices of cellular neural network system
Authors: Zaman Shahid , Shabbir Naila 
Published: February 2023

Abstract
The Cellular Neural Network (CNN) execute high-speed calculations, geometric maps, non-linear processing, image processing, and other parallel processing tasks. It is an analogue paradigm made up of a collection of cells that are locally coupled to one another. Different arrangements of cells are possible. An input, a state, and an output are present in each cell. Only neighboring cells can communicate with one another in a cellular neural network. It can be seen graphically, with the interconnections between cells represented by edges and the cells themselves by vertices. Uniquely suited for high-speed parallel signal processing are cellular neural networks. The continuous-time aspect of cellular neural networks enables real-time signal processing, while the local interconnection feature makes them particularly suited for VLSI implementation. Cellular neural networks combine the best features of both worlds. Topological descriptors are employed in chemical graph theory to investigate graph structure and biological activity. The entire graph can be described by a single value. The irregular topological indices for CNN have been computed in this paper. The obtained results are useful to CNN networks of any size. The applications of CNN in image processing, partial differential equations, 3D surface analysis, sensory-motor organ modelling, and biological vision modelling are all improved by these studies.