bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group
Authors: Barilà Gregorio , Quaglia Francesca Maria , Furlan Anna , Pescosta Norbert , Bonalumi Angela , Marcon Chiara , Pascarella Anna , Tinelli Martina , De March Elena , Lico Albana , Sartori Roberto , Clissa Cristina , De Sabbata Giovanni , Nappi Davide , Porrazzo Marika , De Marchi Roberta , Pavan Laura , Tosetto Alberto , Gherlinzoni Filippo , Krampera Mauro , Bassan Renato , Patriarca Francesca , Semenzato Gianpietro , Zambello Renato 
Published: September 2023

AbstractTreatment of lenalidomide refractory (Len-R) multiple myeloma (MM) patients still represents an unmet clinical need. In the last years, daratumumab-bortezomib-dexamethasone (D-VD) combination was extensively used in this setting, even though only a small fraction of Len-R patients was included in the pivotal trial. This real-life study aimed to evaluate the efficacy and safety of the D-VD regimen in a cohort that exclusively enrolled Len exposed or refractory MM patients. The study cohort included 57 patients affected by relapsed/refractory MM. All patients were previously exposed to Len, with 77.2% being refractory. The overall response rate (ORR) was 79.6% with 43% of cases obtaining at least a very good partial response (VGPR). The D-VD regimen showed a favorable safety profile, with low frequency of grade 3–4 adverse events, except for thrombocytopenia observed in 21.4% of patients. With a median follow-up of 13 months, median progression-free survival (PFS) was 17 months. No significant PFS differences were observed according to age, ISS, LDH levels, type of relapse, and high-risk FISH. Len exposed patients displayed a PFS advantage as compared to Len refractory patients (29 vs 16 months, p = 0.2876). Similarly, patients treated after Len maintenance showed a better outcome as compared to patients who had received a full-dose Len treatment (23 vs 13 months, p = 0.1728). In conclusion, our real-world data on D-VD combination showed remarkable efficacy in Len-R patients, placing this regimen as one of the standards of care to be properly taken into account in this MM setting.
Long-term outcome of natalizumab-associated progressive multifocal leukoencephalopathy in Austria: a nationwide retrospective study
Authors: Moser Tobias , Zimmermann Georg , Baumgartner Anna , Berger Thomas , Bsteh Gabriel , Di Pauli Franziska , Enzinger Christian , Fertl Elisabeth , Heller Thomas , Koppi Stefan , Rommer Paulus S. , Safoschnik Georg , Seifert-Held Thomas , Stepansky Robert , Sellner Johann 
Published: September 2023

Abstract
Background/objective
The use of natalizumab (NAT) in multiple sclerosis (MS) may be complicated by progressive multifocal leukoencephalopathy (PML), a rare and life-threatening opportunistic brain infection. We aimed to analyze the course of MS after PML recovery together with the long-term outcome of NAT-associated PML (NAT-PML) in Austria.

Methods
Retrospective study based on identification of cases in the nationwide Austrian MS treatment registry (AMSTR) and MS centers with review of patient records. The expanded disability status scale (EDSS) was used to measure neurological disability and outcome.

Results
As of December 2022, we identified 15 NAT-PML cases in Austria; only 20% occurred after 2016, when increased vigilance commenced. Two patients did not survive acute PML, and an additional patient died five years later, yielding a mortality rate of 20%. Seizures occurred exclusively in patients with pronounced EDSS increase. Gadolinium (Gd)-enhancement on brain magnetic resonance imaging (MRI) on PML suspicion was associated with minor changes of post-PML neurological disability. Long-term follow-up of up to 132 months (median 76 months) was available in 11/15. The overall median EDSS increased from 3.5 at pre-PML to 6.5 at the last assessment. Regarding inflammatory MS-related disease activity during the observation period, one single individual experienced an MS relapse and another patient had two Gd-enhancing brain lesions. Three patients converted to progressive MS within three years from PML and the EDSS further increased in 6/11.

Conclusions
The number of NAT-PML cases is decreasing over time. While many patients accumulated severe persistent neurological deficits compared to pre-PML, inflammatory MS-related disease activity after PML recovery was rare.
Deformation, seismicity, and monitoring response preceding and during the 2022 Fagradalsfjall eruption, Iceland
Authors: Parks Michelle , Sigmundsson Freysteinn , Drouin Vincent , Hjartardóttir Ásta R. , Geirsson Halldór , Hooper Andrew , Vogfjörd Kristín S. , Ófeigsson Benedikt G. , Hreinsdóttir Sigrún , Jensen Esther H. , Einarsson Páll , Barsotti Sara , Fridriksdóttir Hildur M. 
Published: September 2023

AbstractFollowing two periods of dike intrusion in 2021 at Fagradalsfjall, Iceland, one of which led to an eruption, a third dike intrusion commenced on 30 July 2022. A sudden increase in seismicity occurred within the diking area, with approximately 1700 automatically detected earthquakes > M1 within 24 h. Strong earthquakes were felt over several days within a wider area (largest MW 5.3). The timeline and spatial distribution of seismicity suggested it resulted from diking, together with triggered seismicity in nearby areas releasing stored tectonic stress. Geodetic observations revealed displacements consistent with a dike intrusion, and geodetic modeling on 2 August revealed a best-fit model with a shallow top depth of the dike (~1 km), and high magma inflow rate (~49 m3/s). Also considering a decline in seismicity, a warning was issued that the likelihood of a new eruption in the coming days was high. An effusive eruption started the next day (3 August) on a ~375-m-long fissure, with an initial extrusion rate of 32 m3/s. The projected surface location of the dike (from the optimal model) was within 49–110 m of the eruptive fissure. We present a timeline of the activity and monitoring response in the days both preceding and following the eruption onset. We compare the details of the activity that occurred prior to this diking and eruption to the previous events at Fagradalsfjall to improve understanding of unrest preceding eruptions.
Distributing Persistent Homology via Spectral Sequences
Authors: Torras-Casas Álvaro 
Published: September 2023

AbstractWe set up the theory for a distributed algorithm for computing persistent homology. For this purpose we develop linear algebra of persistence modules. We present bases of persistence modules, together with an operation $$\boxplus $$
⊞
that leads to a method for obtaining images, kernels and cokernels of tame persistence morphisms. Our focus is on developing efficient methods for the computation of homology of chains of persistence modules. Later we give a brief, self-contained presentation of the Mayer–Vietoris spectral sequence. Then we study the Persistent Mayer–Vietoris spectral sequence and present a solution to the extension problem. This solution is given by finding coefficients that indicate gluings between bars on the same dimension. Finally, we review PerMaViss, an algorithm that computes all pages in the spectral sequence and solves the extension problem. This procedure distributes computations on subcomplexes, while focusing on merging homological information. Additionally, some computational bounds are found which confirm the distribution of the method.
Diagnostik und Therapie der Fokal-Segmentalen Glomerulosklerose – 2023
Authors: Gauckler Philipp , Zitt Emanuel , Regele Heinz , Eller Kathrin , Säemann Marcus D. , Lhotta Karl , Neumann Irmgard , Rudnicki Michael , Odler Balazs , Kronbichler Andreas , Zschocke Johannes , Windpessl Martin 
Published: September 2023

ZusammenfassungDer histopathologische Begriff fokal-segmentale Glomerulosklerose umfasst verschiedene Krankheitsprozesse mit dem gemeinsamen Kennzeichen einer großen Proteinurie und dem namensgebenden glomerulären Schädigungsmuster in der Lichtmikroskopie. Eine Einteilung in primäre, sekundäre und genetische Formen anhand der zugrundeliegenden Pathogenese ist daher von großer Relevanz. Die exakte Pathogenese der primären fokal-segmentalen Glomerulosklerose ist ungeklärt, allerdings wird – analog zur Minimal-change Glomerulopathie – eine autoimmun-vermittelte Schädigung der Podozyten angenommen. Angesichts des ähnlichen Pathomechanismus findet zunehmend die vereinende Bezeichnung „Podozytopathie“ Verwendung. Supportive Therapiemaßnahmen zum Erhalt der Nierenfunktion sind bei allen Formen angezeigt. Demgegenüber sollten immunsuppressive Therapien nur bei der primären fokal-segmentalen Glomerulosklerose zum Einsatz kommen. Komplizierte Verläufe umfassen steroid-abhängige, steroid-resistente und häufig relapsierende Formen und erfordern den Einsatz alternativer Therapiestrategien. Die Österreichische Gesellschaft für Nephrologie (ÖGN) stellt hier einen gemeinsamen Konsens darüber vor, wie erwachsene PatientInnen mit fokal-segmentaler Glomerulosklerose am besten diagnostiziert und behandelt werden können.
Allgemeine Empfehlungen für die Behandlung glomerulärer Erkrankungen – 2023
Authors: Windpessl Martin , Gauckler Philipp , Zitt Emanuel , Lhotta Karl , Ay Cihan , Eller Kathrin , Odler Balazs , Neumann Irmgard , Rudnicki Michael , Kronbichler Andreas , Säemann Marcus D. 
Published: September 2023

ZusammenfassungGlomeruläre Erkrankungen sind mit extrarenalen Komplikationen vergesellschaftet, etwa mit thromboembolischen Ereignissen, einem erhöhten kardiovaskulären Risiko und insbesondere einer deutlich erhöhten Neigung zu Infektionen. Daher ist eine genaue Kenntnis der verschiedenen Immunsuppressiva und ihrer typischen Nebenwirkungsprofile von großer Bedeutung. Während Nephrolog:innen mit Calcineurin-Inhibitoren und Antimetaboliten üblicherweise aus der Transplantationsmedizin viel Erfahrung aufweisen, kommen zwei für die Therapie immunmediierter Nierenerkrankungen relevante Wirkstoffe (Rituximab, in schwerwiegenden Fällen auch Cyclophosphamid) vergleichsweise selten zur Anwendung und werden hier vertiefend besprochen. Außerdem werden praxisgerechte Empfehlungen zur Thromboseprophylaxe beim nephrotischen Syndrom sowie zur Vorbeugung einer wichtigen opportunistischen Infektion, der Pneumocystis jirovecii Pneumonie, gegeben.
Stenotrophomonas maltophilia in people with Cystic Fibrosis: a systematic review of prevalence, risk factors and management
Authors: Terlizzi Vito , Tomaselli Marta , Giacomini Giulia , Dalpiaz Irene , Chiappini Elena 
Published: September 2023

AbstractTo summarize the current knowledge of the clinical impact of Stenotrophomonas maltophilia (SM) in cystic fibrosis (CF) patients. A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline recommendations, was performed through searches in PubMed and EMBASE databases, and CF National and International Registries websites from 2000 to 2022. Overall, 184 articles were initially retrieved, out of which 15 were selected and included in the review. Data form 6 Registries and 9 pertinent articles from the references of the studies selected were also considered, resulting in 30 studies in total. The prevalence of SM in patients with CF is increasing in Europe while it is declining in North America. The role of chronic colonization of SM on lung function and clinical status in CF patients is still under debate. The most recent studies suggested a pathogenic role of SM chronic infections in CF patients with an acceleration in lung function decline, an increase in hospitalization rates and an association with co-infection. Reflecting the uncertainty about the role of SM in CF, little is available about antibiotic therapeutic strategies for both acute exacerbations and chronic infections. Antimicrobial therapy should be performed in the acute exacerbations, while it may be reasonable to attempt eradication when the first colonization is identified. Nevertheless, it is not established which antibiotic regimen should be preferred, and overtreatment could contribute to the selection of antimicrobial-resistant strains. Further studies are warranted in this regard.
Projected global mercury supply, demand, and excess to 2050 based on impacts of the Minamata Convention
Authors: Sodeno Reiko 
Published: September 2023

AbstractThere is a crucial need to understand the outlook for changes in mercury supply and demand in response to the 2017 entry into force of the Minamata Convention on Mercury. If demand exceeds supply there will be a shortage, but if supply exceeds demand there will be excess mercury, and ultimately the need to prepare for the final disposal of elemental mercury. This study estimates global mercury supply and demand from 2010 to 2050, by region, and projects excess mercury based on recent trends and consideration of impacts of the Convention. The analysis notes a downward trend in both supply and demand, but the supply of mercury from primary mining has not decreased as much as initially expected, while mercury recovery from by-products of nonferrous production has not yet been implemented extensively. Under a business-as-usual projection, there is excess supply until a shortage appears around 2030, but a surplus returns after 2035, and there is a projected excess supply of 59 tons annually in 2050. Relying on the level of mercury recovery in the nonferrous sector, global cumulative stock of excess mercury is projected at 14,439–20,943 tons in 2050.
Frost hardiness of Finnish plus tree progenies of Scots pine from seed orchards in Finland and Ukraine
Authors: Wu Dongxia , Pulkkinen Pertti , Pappinen Ari , Neyko Ihor , Zhang Gang , Di Bao , Heinonen Jaakko , Repo Tapani 
Published: September 2023

AbstractTo avoid the surrounding pollination, seed orchards of Finnish plus trees have been established in Ukraine, i.e., far from their natural distribution. However, it is unknown whether the pollination site affects the frost hardiness (FH) of the progenies and thus their use in forest regeneration in Finland. Using whole-plant freezing tests, we examined the FH of plus tree seed orchard progenies in Finland and Ukraine, with three lots of seeds from each orchard, twice during cold acclimation in controlled conditions. The FH of needles, as assessed immediately after the freezing tests, was higher in the Finnish than Ukrainian seed orchard progenies. The variation in the FH of needles was high among the progenies, ranging from − 44 to − 79 °C by relative electrolyte leakage (REL), and from − 29 to − 46 °C by chlorophyll fluorescence (CF). However, when FH was assessed based on the growth of shoots and roots in the greenhouse after three weeks, the differences between the progenies and orchards disappeared. The FH was then between − 10 and − 15 °C based on shoot growth, between − 6 and − 12 °C based on root growth, and between − 8 and − 16 °C based on the number of new root tips. The results imply an epigenetic effect on FH of needles but no effect of progeny or orchard on FH of roots. In summary, it seems to be possible to use seed produced in southern Ukraine in practical reforestation actions in southern Finland.
Potential individual and interactive effects of climate and land-cover changes on bats and implications for conservation planning: a case study in Vietnam
Authors: Tuan Le Quang , Thong Vu Dinh , Son Nguyen Truong , Tu Vuong Tan , Tuan Tran Anh , Luong Nguyen Thanh , Vy Nguyen Tran , Thanh Hoang Trung , Huang Joe Chun-Chia , Csorba Gábor , Görföl Tamás , Tuanmu Mao-Ning 
Published: September 2023

AbstractClimate and land-cover changes are among major threats to biodiversity. However, the interactive effects of the two threats are often overlooked in conservation planning. Using 81 bat species occurring in Vietnam as a case, we investigated the individual and interactive effects of climate and land-cover changes, highlighting the importance of this information for conservation efforts. By using species distribution models, we predicted the potential changes in range size among species and in species richness across Vietnam by the 2050s, considering projected climate and land-cover changes under two emission scenarios. Our results revealed that both threats individually would have predominantly negative effects on bats in Vietnam. Moreover, when these threats occur simultaneously, their interactions would generally intensify the impacts by mitigating individual positive effects and/or enhancing negative effects. However, we also found large interspecific and geographic variations in the direction and magnitude of these effects. Forest specialists, insectivores and cave-roosting species were predicted to be particularly vulnerable to the negative effects, with northern and southern Vietnam being more affected. These results underscore the urgent need to incorporate both climate and land-cover changes, as well as their interactions, into conservation planning for bats in Vietnam and biodiversity in general. The species-specific and spatially-explicit information regarding the impacts of the two threats can guide conservation actions, allowing us to target more manageable and less uncertain threats, as well as prioritize the protection of more vulnerable species.
Conceptual Basis for a Sustainable and Fire Resilient Built Environment
Authors: McNamee Margaret , Meacham Brian J. 
Published: September 2023

Abstract
Fire has the potential to create significant impacts on the built environment. Managing this impact is sometimes pursued without consideration of the interface between the natural and technological worlds. However, as society has recognized the impacts of technological development on environmental sustainability, the need for sustainable and resilient development has emerged. To facilitate sustainable and resilient development, technological choices should embrace a sociotechnical systems approach that considers the interactions of society, technology and institutions, and their interactions with the environment. Failure to do so can result in unintended consequences. Society’s technological choices aimed at increasing sustainability of buildings, such as the desire to reduce building carbon footprints or improve the use of renewable energy systems, can have significant impacts on fire resilience if not considered holistically. To better understand and comprehensively address and mitigate intolerable fire risk associated with choices driven by sustainability objectives, a balanced and holistic systems approach is needed. To this end, a framework to foster a systems-oriented approach to improving both sustainability and fire resilience, in tandem, to create a Sustainable and Fire Resilient Built Environment (SAFR-BE) is presented.
Kaminari Kagura: the “lightning bolt shape” technique for posterior vitreous detachment induction
Authors: Caporossi Tomaso , Gambini Gloria , Baldascino Antonio , Scampoli Alessandra , Carlà Matteo Mario , Rizzo Stanislao 
Published: September 2023

Abstract
Purpose
To describe and evaluate the effectiveness of the Kaminari Kagura technique as a posterior hyaloid detachment treatment.

Study design
This was a prospective, consecutive, randomized interventional study.

Methods
This study examined 30 eyes from 30 patients divided into two groups: (1) a Kaminari Kagura group (15 eyes) and (2) a control group (15 eyes) scheduled for vitrectomy with an optical coherence tomography (OCT)-based diagnosis of adherent posterior hyaloid.

Results
The mean time for posterior vitreous detachment (PVD) induction in the Kaminari Kagura group was 58 ± 6.6 s, and that in the control group was 69 ± 9 s (p < 0.005). No intra- or post-operative complications were reported.

Conclusions
The Kaminari Kagura technique results in effective posterior hyaloid detachment in less time than that required for posterior vitreous cortex engagement.
The influence of an internal variable heat source on the perfect contact of three thermoelastic layers characterized by hereditary features
Authors: Sherief H. , Abd El-Latief A. M. , Fayik M. 
Published: September 2023

AbstractIn this work, we present a two-dimensional problem of thermoelastic and thermo-viscoelastic materials which consists of three thick layers with a finite thickness and infinite extent. These layers are placed in a perfect contact one on top of another. The outer surfaces of the layers are assumed to be thermally isolated and rigidly fixed. There is a disturbed variable heat source filling the middle layer. Continuity conditions between the layers ensure the continuity of the temperature, normal heat flux, displacement, and normal stresses across layers. Laplace and exponential Fourier transforms are used to solve the problem. Inverse transforms are computed numerically to obtain the solution in the physical domain. Graphical results are presented and discussed for all variable fields.
A machine learning approach to predicting plant available phosphorus that accounts for soil heterogeneity and regional variability
Authors: Hall Rebecca L. , de Santana Felipe Bachion , Grunsky Eric C. , Browne Margaret A. , Lowe Victoria , Fitzsimons Mairéad , Higgins Suzanne , Gallagher Vincent , Daly Karen 
Published: September 2023

Abstract
Purpose
Mehlich-3 extractable P, Al, Ca, and Fe combined with pH can be used to help explain soil chemical processes which regulate P retention, such as the role of Al, Ca, Fe, and pH levels in P fixation and buffering capacity. However, Mehlich-3 is not always the standard test used in agriculture. The objective of this study is to assess the most reliable conversion of Mehlich-3 Al, Ca, Fe, and P and pH into a commonly used soil P test, Morgan’s P, and specifically to predict values into decision support for fertiliser recommendations.

Methods
A geochemical database of 5631 mineral soil samples which covered the northern area of Ireland was used to model soil test P and P indices using Mehlich-3 data.

Results
A random forest machine learning algorithm produced an R2 of 0.96 and accurately predicted soil P index from external validation in 90% of samples (with an error range of ± 1 mg L−1). The model accuracy was reduced when predicted Morgan’s P concentration was outside of the sampled area.

Conclusions
It is recommended that random forest is used to produce Mehlich-3 conversions, especially when data covers large spatial scales with large heterogeneity in soil types and regional variations. To implement conversion models into P testing regimes, it is recommended that representative soil types/geochemical attributes are present in the dataset. Furthermore, completion of a national scale geochemical survey is needed. This will enable accurate predictions of Morgan’s P concentration for a wider range of soils and geographical scale.