bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Synthesis of MXene with Tunable Morphology by Electrochemical Etching of MAX Phase Prepared in Molten Salt
Authors: Liu Liyuan , Zschiesche Hannes , Antonietti Markus , Gibilaro Mathieu , Chamelot Pierre , Massot Laurent , Rozier Patrick , Taberna Pierre‐Louis , Simon Patrice 
Published: December 2022

AbstractMXenes, a rapidly growing family of 2D transition metal carbides, carbonitrides, and nitrides, are one of the most promising high‐rate electrode materials for energy storage. Despite the significant progress achieved, the MXene synthesis process is still burdensome, involving several procedures including preparation of MAX, etching of MAX to MXene, and delamination. Here, a one‐pot molten salt electrochemical etching (E) method is proposed to achieve Ti2C MXene directly from elemental substances (Ti, Al, and C), which greatly simplifies the preparation process. In this work, different carbon sources, such as carbon nanotubes (CNT) and reduced graphene oxide (rGO), are reacted with Ti and Al micro‐powders to prepare Ti2AlC MAX with 1D and 2D tuned morphology followed by in situ electrochemical etching from Ti2AlC MAX to Ti2CTx MXene in low‐cost LiCl‐KCl. The introduction of the O surface group via further ammonium persulfate (APS) treatment can act in concert with Cl termination to activate the pseudocapacitive redox reaction of Ti2CClyOz in the non‐aqueous electrolyte, resulting in a Li+ storage capacity of up to 857 C g−1 (240 mAh g−1) with a high rate (86 mAh g−1 at 120 C) capability, which makes it promising for use as an anode material for fast‐charging batteries or hybrid devices in a non‐aqueous energy storage application.
An evolutionary framework for understanding habitat partitioning in plants
Authors: Toll Katherine 
Published: December 2022

AbstractMany plant species with overlapping geographic ranges segregate at smaller spatial scales. This spatial segregation—zonation when it follows an abiotic gradient and habitat partitioning when it does not—has been experimentally investigated for over a century often using distantly related taxa, such as different genera of algae or barnacles. In those foundational studies, trade‐offs between stress tolerance and competitive ability were found to be the major driving factors of habitat partitioning for both animals and plants. Yet, the evolutionary relationships among segregating species are usually not taken into account. Since close relatives are hypothesized to compete more intensely and are more likely to interact during mating compared to distant relatives, the mechanisms underlying habitat partitioning may differ depending on the relatedness of the species in question. Here, I propose an integration of ecological and evolutionary factors contributing to habitat partitioning in plants, specifically how the relative contributions of factors predictably change with relatedness of taxa. Interspecific reproductive interactions in particular are understudied, yet important drivers of habitat partitioning. In spatially segregated species, interspecific mating can reduce the fitness of rare immigrants, preventing their establishment and maintaining patterns of spatial segregation. In this synthesis, I review the literature on mechanisms of habitat partitioning in plants within an evolutionary framework, identifying knowledge gaps and detailing future directions for this rapidly growing field of study.
Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy
Authors: Zhou Jie , Yu Qiao , Song Juan , Li Shan , Li Xiang‐Ling , Kang Bin , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: December 2022

AbstractCuproptosis is a new form of programmed cell death and exhibits enormous potential in cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and maximizing the copper‐induced therapeutic effect in cancer sites are two main challenges. In this study, we constructed a photothermally triggered nanoplatform (Au@MSN‐Cu/PEG/DSF) to realize on‐demand delivery for synergistic therapy. The released disulfiram (DSF) chelated with Cu2+ in situ to generate highly cytotoxic bis(diethyldithiocarbamate)copper (CuET), causing cell apoptosis, and the formed Cu+ species promoted toxic mitochondrial protein aggregation, leading to cell cuproptosis. Synergistic with photothermal therapy, Au@MSN‐Cu/PEG/DSF could effectively kill tumor cells and inhibit tumor growth (inhibition rate up to 80.1 %). These results provide a promising perspective for potential cancer treatment based on cuproptosis, and may also inspire the design of advanced nano‐therapeutic platforms.
Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4‐Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family
Authors: Kirchgäßner Sören , Braun Michael B. , Bartlick Natascha , Koç Cengiz , Reinkemeier Christopher D. , Lemke Edward A. , Stehle Thilo , Schwarzer Dirk 
Published: December 2022

AbstractLysine acetylation is a charge‐neutralizing post‐translational modification of proteins bound by bromodomains (Brds). A 1,2,4‐triazole amino acid (ApmTri) was established as acetyllysine (Kac) mimic recruiting Brds of the BET family in contrast to glutamine commonly used for simulating this modification. Optimization of triazole substituents and side chain spacing allowed BET Brd recruitment to ApmTri‐containing peptides with affinities similar to native substrates. Crystal structures of ApmTri‐containing peptides in complex with two BET Brds revealed the binding mode which mirrored that of Kac ligands. ApmTri was genetically encoded and recombinant ApmTri‐containing proteins co‐enriched BRD3(2) from cellular lysates. This interaction was blocked by BET inhibitor JQ1. With genetically encoded ApmTri, biochemistry is now provided with a stable Kac mimic reflecting charge neutralization and Brd recruitment, allowing new investigations into BET proteins in vitro and in vivo.
Discrete Molecular Copper(II) Complex for Efficient Piezoelectric Energy Harvesting Above Room‐Temperature
Authors: Haldar Rajashi , Kumar Ajay , Mallick Binit , Ganguly Swaroop , Mandal Dipankar , Shanmugam Maheswaran 
Published: December 2022

AbstractDeveloping robust, wearable, and biocompatible energy harvesting devices with bulk oxides (ceramics and perovskites) is extremely hard to achieve due to their zero mechanical flexibility, heavy metal toxicity, and tunability of properties. Alternatively, discrete inorganic complexes can be an excellent choice to overcome the above‐stated issues, thanks to appropriate molecular engineering. Herein, we report an above‐room‐temperature ferroelectric discrete molecular complex [Cu(L‐phe)(bpy)(H2O)]PF6⋅H2O (1) which is suitable for piezoelectric energy harvesting due to its large values of piezoelectric co‐efficient (d33=10 pm V−1) and spontaneous polarization (Ps=1.3 μC cm−2). Among the devices prepared with the composite films of polyvinyl alcohol (PVA) and various weight % composition of 1, the 10 Wt % composite shows the highest output voltage of 8 V, a power density of 0.85 μW cm−2, and output current of 5 μA, which is highest for any discrete inorganic complex reported to date.
Characterization and Application of Supramolecular Junctions
Authors: Li Xiaohui , Ge Wenhui , Guo Shuhan , Bai Jie , Hong Wenjing 
Published: December 2022

AbstractThe convergence of supramolecular chemistry and single‐molecule electronics offers a new perspective on supramolecular electronics, and provides a new avenue toward understanding and application of intermolecular charge transport at the molecular level. In this review, we will provide an overview of the advances in the characterization technique for the investigation of intermolecular charge transport, and summarize the experimental investigation of several non‐covalent interactions, including π‐π stacking interactions, hydrogen bonding, host‐guest interactions and σ‐σ interactions at the single‐molecule level. We will also provide a perspective on supramolecular electronics and discuss the potential applications and future challenges.
Recent advances in soy protein extraction technology
Authors: Zhao Yuan , Tian Ran , Xu Zejian , Jiang Lianzhou , Sui Xiaonan 
Published: December 2022

AbstractProtein extraction from soybeans is a vital part of the soy industry. Traditionally, the extraction of soy protein has been done by alkaline extraction and isoelectric precipitation. With the advancement of technology, more extraction techniques have been developed, and are superior to this traditional method. In this review, the composition and classification of soy protein are summarized. Next, the current emerging technologies for soy protein extraction are highlighted. Three extraction technologies, namely reverse micellar, enzyme‐assisted and membrane ultrafiltration, are reviewed in detail. Finally, the research prospects and trends of soy protein extraction technology are also summarized.
Development of a novel epoxy resin based on epoxidized chia oil as matrix and maleinized chia oil as bio‐renewable crosslinker
Authors: Dominguez‐Candela Ivan , Perez‐Nakai Aina , Torres‐Roca Elena , Lora‐Garcia Jaime , Fombuena Vicent 
Published: December 2022

AbstractIn this work novel thermosetting resins with high bio‐based content have been developed derived from chia seed oil (CO). Epoxidized chia seed oil (ECO) was used as bio‐based epoxy matrix with different mixtures of crosslinker agents, that is, methyl nadic anhydride (MNA) as petroleum‐derived and maleinized chia seed oil (MCO) as bio‐based crosslinker. The chemically modified oils from CO, that is, ECO and MCO, and MNA were analyzed by titration and FT‐IR. Additional 1H NMR analysis was performed to characterize MCO structure. Two different behaviors were observed using the mixtures of crosslinkers. On one hand, MNA increases the rigidity with bio‐based content of 54.2%. On the other hand, the addition of MCO provides higher ductility with bio‐based content up to 98%. The same trend was observed by DMTA analysis. The novel cured resins were successfully crosslinked as demonstrated by the mechanical properties, FT‐IR analyses, and gel content. Based on the results, it is concluded that MCO presents higher reactivity than MNA, decreasing curing time with possible energy saving at industrial level. In general, the results showed that adding the appropriate amount of MCO, green thermosetting resins with the desired thermal and mechanical properties can be manufactured with high bio‐based content.
The combination of Astragalus membranaceus and ligustrazine mitigates cerebral ischemia‐reperfusion injury via regulating NR2B‐ERK/CREB signaling
Authors: Tang Xialing , Xie Shanshan , Wang Huajun , Li Yingbin , Lai Zhiyu , Sun Shuangxi , Pan Ruanhuan , Huang Yan , Cai Jun 
Published: December 2022

AbstractBackground and purposeCerebral ischemia‐reperfusion (I/R) injury is a major factor underlying the high mortality and morbidity rates in stroke patients. Our previous study found that the combination of Astragalus membranaceus extract and ligustrazine (Ast+Lig) treatment could protect brain tissues against inflammation in rats with thrombolytic cerebral ischemia. Activation of N‐methyl‐D‐aspartate receptors (NMDAR) is implicated in brain damage induced by cerebral I/R injury.MethodsWe used in vivo and in vitro models of cerebral I/R injury for middle cerebral artery occlusion/reperfusion in mice and oxygen‐glucose deprivation/reoxygenation in primary rat cerebral cortical neurons to evaluate the protective effects of Ast+Lig on cerebral I/R injury, and whether the protective mechanism was related to the regulation of NMDAR‐ERK/CREB signaling.ResultsTreatment with Ast+Lig, or MK‐801 (an inhibitor of NMDAR) significantly ameliorated neurological deficits, decreased infarct volumes, suppressed neuronal damage and Ca2+ influx, and maintained the mitochondrial membrane potential in vivo and in vitro following cerebral I/R injury based on 2,3,5‐triphenyl tetrazolium chloride staining, immunohistochemistry, and immunofluorescent staining. Furthermore, treatment with Ast+Lig evidently prevented the upregulation of NR2B, but not NR2A, in vivo and in vitro following cerebral I/R injury based on western blotting and reverse transcription‐quantitative PCR analyses. Moreover, treatment with Ast+Lig significantly increased the phosphorylation of ERK and CREB, as well as increasing their mRNA expression levels in vivo and in vitro following cerebral I/R injury.ConclusionsThe overall results thus suggest that the Ast+Lig combination conferred neuroprotective properties against cerebral I/R injury via regulation of the NR2B‐ERK/CREB signaling pathway.
Synthesis of Two Novel Optically Active #‐Shaped Cyclic Tetramers Based on Planar Chiral [2.2]Paracyclophanes
Authors: Morisaki Aoi , Inoue Ryo , Morisaki Yasuhiro 
Published: December 2022

AbstractThis study reports the synthesis of optically active cyclic tetramers comprising four stacked π‐electron systems from two enantiomerically pure [2.2]paracyclophane compounds (bis‐(para)‐pseudo‐ortho‐ and bis‐(para)‐pseudo‐meta‐tetrasubstituted [2.2]paracyclophane compounds). Depending on the combination of the absolute configurations of the planar chiral pseudo‐ortho‐ and pseudo‐meta‐[2.2]paracyclophane units, the cyclic tetramers formed either parallel‐#‐ or weave‐#‐structures. The optical and chiroptical properties of both structures were investigated experimentally and theoretically. In particular, the weave‐#‐shaped cyclic tetramer exhibited good chiroptical properties and emitted circularly polarized luminescence (CPL) with a high anisotropy factor (|glum| value of the order of 10−3) and a CPL brightness (BCPL) higher than 100.
Asymmetrical Platinum and Rhodium Dinuclear Complex Strongly Bound to Filled d Complexes by Unbridged Pt−Metal Bonds: Toward Heterometallic‐Extended Metal Atom Chains
Authors: Uemura Kazuhiro , Ikeda Yuya , Takamori Atsushi , Takeyama Tomoyuki , Iwatsuki Satoshi 
Published: December 2022

AbstractHeterometallic extended metal atom chains (EMACs) aligned with three types of metal were rationally synthesized by forming unbridged metal−metal bonds based on the interactions between highest occupied and lowest unoccupied molecular orbitals at the d
orbital. These chains form pentanuclear structures aligned as Rh−Pt−M−Pt−Rh with relatively large formation constants of 5.0×1013 M−2 for M=Pt and 6.3×1011 M−2 for M=Pd, while retaining their backbones in solution. In the case of M=Cu, the original Cu(+2) atoms were reduced to Cu(+1) during the synthetic process. Cu(+1) has an unprecedented trigonal bipyramidal coordination geometry. The reported synthesis based on asymmetrical dinuclear complexes provides a guideline for the synthesis of hetero‐EMACs to allow several analogs through judicious combinations realized by tuning the number of metal nuclei and metal species.
Nanopores/Nanochannels Based on Electrical and Optical Dual Signal Response for Application in Biological Detection†
Authors: Lu Guangwen , Lin Niya , Chen Zhaojun , Jiang Wenlian , Hu Jing‐Jing , Xia Fan , Lou Xiaoding 
Published: December 2022

Comprehensive SummaryCancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.
Accuracy of fine‐needle aspiration cytopathology to differentiate malignant and benign thyroid nodules with ≥4 cm diameter: A retrospective study
Authors: Rastegar Houra , Torshizian Ashkan , Yaghoubi Mohammad Ali , Khoshhal Nastaran , Asadi Mehdi , Morovatdar Negar , Mohebbi Masoud 
Published: December 2022

AbstractBackgroundThyroid nodules (TN) are commonly present in the general population and are usually pathologically benign. An initial diagnosis with fine‐needle aspiration (FNA) cytopathology could help clinical decision‐making with fewer complications. As the previous studies suggest surgical procedures for >4 cm TNs, we aimed to investigate the accuracy of preoperative FNA cytology to predict malignancy risk in these nodules in a sample of the Iranian population.MethodsPatients with ≥4 cm TNs who had preoperative FNA cytology, underwent nodulectomy and had a histopathological report were included. Each patient's preoperative demographic, ultrasonographic, and cytology data were gathered. After surgery, resected samples were assessed pathologically and diagnosed as benign or malignant. Finally, data were analyzed to evaluate the presurgical accuracy of the FNA cytology.ResultsWe identified 41 (51.25%) patients with malignant legions among our study population (N = 80). The pathology reports were indeterminate in 3 patients with follicular neoplasm. Bethesda scores were substantially higher in patients with malignancy. The sensitivity, specificity, and false‐negative rate of FNA cytology reports using the Bethesda system were 73.7%, 74.2%, and 26.3%, respectively. There was no association between malignancy and TNs' size, neither their volume nor their highest diameter.ConclusionFNA cytology is not as sensitive and specific in nodules>4 cm as in smaller ones. However, it can still be used alongside other diagnostic procedures in malignancy screening. Clinicians should make more complex decisions considering various influential factors to avoid missing malignant lesions and reduce diverse probable complications of highly invasive diagnostic surgery. Further prospective research on >4 cm TNs and their multiple features' association with malignancy is required for more precise judgment.
Highly Conjugated Bis(benzo[b]phosphole)‐P‐oxides: Synthesis and Electrochemical, Optical, and Computational Studies
Authors: D'Imperio Nicolas , Pelliccioli Valentina , Grecchi Sara , Bossi Alberto , Vasile Francesca , Cauteruccio Silvia , Arkhypchuk Anna I. , Kumar Gupta Arvind , Orthaber Andreas , Ott Sascha , Licandro Emanuela 
Published: December 2022

AbstractThe first examples of a π‐conjugated benzo[b]phosphole P‐oxide in which two phosphole P‐oxide units are connected by a carbon‐carbon double bond are described. The molecules are synthesized as E isomers with respect to the carbon‐carbon double bond and exist as stable cis and trans isomers (chiral and meso one respectively) relatively to the two stereogenic P atoms. The optical and electrochemical properties of both isomers have been investigated by experiment and computations.
Family dysfunction is associated with chronic pain in a community‐dwelling Japanese population: The Hisayama study
Authors: Saito Takafumi , Shibata Mao , Hirabayashi Naoki , Honda Takanori , Morisaki Yukiko , Anno Kozo , Sudo Nobuyuki , Hosoi Masako , Ninomiya Toshiharu 
Published: December 2022

AbstractBackgroundPoor family functioning has been reported to be associated with the severity of chronic pain in outpatients, but the association has not been fully addressed in general populations. The present study aimed to examine the association between family dysfunction levels and the presence of chronic pain in a community‐dwelling Japanese population.MethodsA total of 2598 participants aged ≥40 years were classified as having healthy, borderline or unhealthy family functioning. Chronic pain was defined as subjective pain for three months or longer, and further classified by pain intensity, the number of chronic pain sites, pain duration and the extent of pain spread. A logistic regression model was used to compute the odds ratios (ORs) for chronic pain outcomes.ResultsThe prevalence of chronic pain was 49%. The age‐ and sex‐adjusted prevalence of total and severe chronic pain were increased significantly with increasing family dysfunction levels (all p for trend <0.01). After adjusting for sociodemographic, physical, social and family structure factors, the ORs (95% confidence intervals [CI]) for having chronic pain among borderline and unhealthy groups were 1.20 (1.01–1.44) and 1.43 (1.15–1.79), respectively, as compared with a healthy family function group. The association was stronger among people who were employed and those who were living with their children. In addition, the ORs for severe chronic pain increased significantly with increasing levels of family dysfunction.ConclusionsThe family dysfunction level was positively associated with the presence as well as the severity of chronic pain in a community‐dwelling population.SignificanceA biopsychosocial burden due to family relationships could worsen the clinical presentation of pain. Social support or family therapy for dysfunctional families would be a potential initiative for the prevention or management of chronic pain.
New electrode material GCE/AgNPs‐D3 as an electrochemical sensor used for the detection of thallium ions
Authors: Modrzejewska‐Sikorska Anna , Konował Emilia , Karbowska Bożena , Szatkowska Dominika 
Published: December 2022

AbstractOptimal working parameters for the innovative electrode GCE/AgNPs‐D3 were determined and the selectivity was assessed. The stripping anodic peak current of thallium characterized in linearity over range from 4.9 ⋅ 10−8 to 4.9 ⋅ 10−7 mol ⋅ dm−3, with LOD = 7.16 ppb (3.5 ⋅ 10−8 mol ⋅ dm−3). Furthermore, the new electrode showed more than sevenfold improvement in the thallium current signal compared to the unmodified electrode GCE. High selectivity was achieved using EDTA disodium salt as a complexing agent for other metals.
Preparation of biomorphic porous La0.8Ce0.2Fe0.3Co0.7O3 perovskite‐type catalysts for automobile exhaust purification
Authors: Xiurong Guo , Yinghui Wang , Haonan Zhang , Du Danfeng , Zhanfeng Qi 
Published: December 2022

AbstractBiomorphic porous La0.8Ce0.2Fe0.3Co0.7O3 perovskite‐type catalysts are synthesized through a facile bio‐templating method taking wood fiber as template for achieving the four‐way purification of PM, NOx, CO, and HC emitted by automobile exhausts. The catalyst samples were characterized by X‐ray diffractometer, Fourier‐transform infrared spectroscopy, scanning electron microscope and Brunauer–Emmett–Teller analysis. The results showed that catalyst sample calcined at 700°C obtained high purity, high surface area (4.01 m2/g), wide pore size distribution and retained the initial wood fiber structure, which was suitable for purifying automobile exhausts. In addition, the performances for four‐way purification under the simulated exhaust were analyzed by simulation test bench. The highest purification efficiency of PM, NOx, HC, and CO can reach 92%, 92%, 98%, and 76%, separately. Moreover, four‐way purification mechanism was deduced according to the theoretical research of Mars‐van krevelen on the redox reaction mechanism and experimental result.