bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-temporal assessment of extreme precipitation events in southeastern Brazil
Authors: Simões José Victor Orlandi , Pedra George Ulguim , Alves Lincoln Muniz , Barreto Naurinete de Jesus da Costa 
Published: February 2023

Abstract
Climate change is a phenomenon directly attributed to human activity due to greenhouse gas emissions and changes in land use and land cover. In this way, climate change has and will have direct and indirect impacts on the components of the climate systems, including the hydrological cycle, through an increase in the frequency and intensity of extreme events, such as heavy rains or droughts, which impact natural systems, groups, and human systems, as well as on economic activity, such as the energy, agricultural and water sectors that are directly dependent on the variables of the hydrological cycle. The southeast region of Brazil (São Paulo, Minas Gerais, Rio de Janeiro, and Espírito Santo) produces 60\% of the national wealth and much of the country's electricity, in addition to housing 80 million people. Extreme weather events have hit this region in recent decades, causing an increasing number of natural disasters. Good examples are the 2014/15 water crisis and the occurrence of heavy rains, particularly in the summers. Given the importance of this theme, the present study aims to analyze the spatial and temporal variability of precipitation over southeast Brazil through the Generalized Extreme Values (GEV) distribution. To this end, seasonal variability and changes in the patterns of precipitation extremes in the period 1981-2020 were analyzed, based on data obtained from the CPC (Climate Predict Center). This research revealed that the frequency and intensity of extreme rainfall events have been changing, notably decreasing during winter.
Using a Co-Construction Participatory Modeling Approach to Understand the Complexity in Collaboratively Managing Knowledge for Multi-Morbid Chronic Disease Patients on Advance Care Plan
Authors: Tulinayo Fiona P. , Ortega-Gil Ana , González Nerea , Erreguerena Irati , Perea Bárbara López , Saralegui Iñaki , Zubeltzu Beñat , Fullaondo Ane , Verdoy Dolores , de Manuel Esteban 
Published: February 2023

Abstract
Across the globe, the healthcare sector is experiencing transformations (cultural, social, digital and economic). This is due to the age and varying patient needs that are driving a shift in the healthcare landscape. At the same time, chronic diseases, social determinants and resource limitations continue to add pressure. Healthcare has thus shifted from paternalistic mode of care to patient centered care (PCC). The growing multiple divergent medical cases denote a need to collaboratively understand clinical issues and effectively determine the best course of action. With PCC, a patient is recognized as a unique human being before forming a diagnosis. This implies that there is a need for multifaceted decision-making. In this study, we use a co-construction participatory modeling approach to understand the complexities in collaboratively managing knowledge for multi-morbid chronic patients on Advance Care Plan (ACP). To achieve this, focus group discussions (FGD) with 12 participants (five healthcare professionals, three health managers and three healthcare key decision makers) from Basque Public Health System (Osakidetza), in Spain were involved in identifying the key challenges and developing a systemic thinking model. As a result, three key challenges were identified i.e. 1) culture (citizens are not willing to talk about death, 2) healthcare professionals’ challenge to change attitude and perspectives, and 3) changing the current system towards holistic and a shared care model. From the developed Causal loop diagrams (CLDs), it is noted that perpetuation of fragmented and paternalistic care is likely to get worse without recognition of the ACP as a social need and a crucial part of the clinical practice part change.
Evaluation of Axial Length and Refractive Results in Patients Undergoing Phacovitrectomy Due to Dense Vitreous Hemorrhage: A Prospective Case Control Study
Authors: Ozturk Yucel , Ağın Abdullah , Gencoglu Aysun Yucel 
Published: February 2023

Abstract
Purpose: To evaluate the axial length (AL) measurement and refractive results in patients who underwent phacovitrectomy due to dense vitreous hemorrhage and to investigate the effectiveness of ultrasound (US) biometry in this patient group.
Methods: In this single-center study, patients with cataract and dense vitreous hemorrhage (VH) who underwent combined phacovitrectomy procedure (Group 1) and patients with cataract who underwent phacoemulsification procedure as control group (Group 2) were included. AL and biometry were performed with US in group 1 and IOL Master 500 in group 2. Postoperatively, AL and biometry of the patients in group 1 were performed with both US and IOL Master 500. Main outcome measures were preoperative and postoperative AL measured by US and IOL Master and refractive outcomes including refractive prediction error (PE), and absolute prediction error (APE).
Results: Median preoperative AL measured by US was 23.33 mm (I), median postoperative AL measured by IOL Master 500 was 23.18 mm (II), and median postoperative AL measured by US (III) was 23.44 mm in group 1 (p=0.04, I- II; p=0.01, I- III; p<0.01, II- III). Preoperative US and postoperative IOL Master 500, and preoperative US and postoperative US AL measurement showed a statistically significant strong positive correlation with a high-reliability coefficient. Median PE and APE were similar between the two groups (p=0.25, p=0.99, respectively).
Conclusions: US biometry can be used easily, safely, and effectively in patients with dense vitreous hemorrhage with near the optimal refractive results.
Percutaneous mesh-container-plasty versus percutaneous kyphoplasty for the treatment of Kümmell's disease: A retrospective cohort study
Authors: Li Yimin , Qian Yunfan , Shen Guangjie , Tang Chengxuan , Zhong Xiqiang , He Shaoqi 
Published: February 2023

Abstract

Background Both percutaneous kyphoplasty (PKP) and percutaneous mesh-container-plasty (PMCP) were important procedures for the treatment of Kümmell's disease. This study aimed to compare the clinical and radiological results of PKP and PMCP for the treatment of Kümmell's disease. Methods This study included patients with Kümmell's disease treated at our center between January 2016 and December 2019. A total of 256 patients were divided into two groups according to the surgical treatment they received. Clinical, radiological, epidemiological, and surgical data were compared between the two groups. Cement leakage, height restoration, deformity correction, and distribution were evaluated. The visual analog scale (VAS), Oswestry Disability Index (ODI), and short-form 36 health survey domains “role-physical” (SF-36 rp) and “bodily pain” (SF-36 bp) were calculated preoperatively, immediately after surgery, and 1-year postoperatively. Results The VAS and ODI scores improved in the PKP [preoperative: 6 (6–7), 68.75 ± 6.64; postoperative: 2 (2–3), 23.25 ± 3.50, respectively] (p < 0.05) and the PMCP [preoperative: 6 (5–7), 67.70 ± 6.50; postoperative: 2 (2–2), 22.24 ± 3.55, respectively] groups (p < 0.05). There were significant differences between the two groups. The mean cost in the PKP group was lower than that in the PMCP group (3697 ± 461 vs. 5255 ± 262 USD,p < 0.05). The cement distribution in the PMCP group was significantly higher than that in the PKP group (41.81 ± 8.82% vs. 33.65 ± 9.24%,p < 0.001). Cement leakage was lower in the PMCP group (23/134) than in the PKP group (35/122) (p < 0.05). The anterior vertebral body height ratio (AVBHr) and Cobb’s angle improved in the PKP (preoperative: 70.85 ± 16.62% and 17.29 ± 9.78°; postoperative: 80.28 ± 13.02% and 13.05 ± 8.40°, respectively) and PMCP (preoperative: 70.96 ± 18.01% and 17.01 ± 10.53°; postoperative: 84.81 ± 12.96% and 10.76 ± 9.23°, respectively) groups (p < 0.05). There were significant differences in vertebral body height recovery and segmental kyphosis improvement between the two groups. Conclusions PMCP had advantages over PKP in terms of pain relief and functional recovery for the treatment of Kümmell's disease. Moreover, PMCP is more effective than PKP in preventing cement leakage, increasing cement distribution, and improving vertebral height and segmental kyphosis, despite its higher cost.
Food Safety Technology Based on Cold Atmospheric Plasma Brush Effect on Different Bacterial Spectrums
Authors: Khatami Shohreh , pour Ghobad Behzadi , aval Sedigheh Fekri 
Published: February 2023

Abstract
The main objective of this work was to design a large-scale cold atmospheric plasma brush (LSCAPB) that can produce a perfectly homogenous large area capable of producing plasma with a length of about 5 cm for studying the inactivation effect of plasma on Gram-positive and Gram-negative bacteria that commonly implicated in Food infections. Gram-positive (L. Monocytogenes, B. Cereus) and Gram-negative (S. Typhi, V. Cholerae) bacteria with an initial population density of 1.5×108 CFU mL− 1 were treated, and their survivability with plasma exposure was examined. The effect of plasma exposure in the reduction of bacteria population was investigated using OD600 absorbance, and changes in cell structure and membrane were studied by scanning electron microscopy (SEM) analysis. Comet assay analysis was used for studying the effect of plasma exposure on DNA damage, and changes in chemical bond were analyzed by FTIR analysis. So, the best destruction is obtained at the voltage of 25 kV for all types of bacteria. This study indicates that the inactivation effect of LSCAPB correlates with the kind of bacteria. We demonstrated LSCAPB can be one of the most efficient methods for the inactivation of different types of bacteria.
Trends in meniscus surgery by patient age and societal changes in Korea from 2010 to 2020
Authors: Kim Yong-Beom , Choi Hyung-Suk , Park Suyeon , Kim Jinjae , Seo Gi-Won 
Published: February 2023

Abstract
Background
Surgery related to the meniscus can be divided into three categories: meniscectomy, meniscal repair and meniscus allograft transplantation (MAT). Meniscus injury is closely related to osteoarthritis, and the patient's age affects the choice of surgical method. As Korean society is rapidly changing into an aging society, the trend of meniscus treatment is expected to change according to the change in age structure.
Methods
This study analyzed longitudinal trends in meniscus surgery (e.g., meniscectomy, meniscal repair, and MAT) in Korea from 2010 to 2020 according to age distribution, hospital size, and region. Data were collected from the Korean Statistical Information Service and the Korean Health Insurance Review and Assessment Service.
Results
During the 2010–2020 study period, the rate of MAT per 1,000,000 people increased from 7.206 to 10.303 (time trend = 1.05; 95% confidence interval [CI]: 1.01–1.10, p = 0.025). The rate of meniscus repair per 1,000,000 people increased from 179.251 to 331.031 (time trend = 1.054; 95% CI: 1.04–1.07; P < 0.001). The rate of meniscectomy per 1,000,000 people decreased from 1301.616 to 1243.763, but the difference was not statistically significant (time trend = 0.991; 95% CI: 0.975–1.006, p = 0.260).
Conclusions
The number of patients presenting for MAT increased during the study period; it significantly increased among individuals aged 10–19 years and 50–59 years. The overall rate of meniscus repair increased; the increase was greatest in general hospitals and orthopedic surgery clinics. The overall rate of meniscectomy did not significantly increase or decrease, although the rate tended to decrease in tertiary hospitals and Seoul.
Energy Intake Equalization During Pregnancy of Obese Mothers: Efects on the Maternal Energy Balance and Fetal Development
Authors: Luz Jacqueline , Ribeiro-Silva Neila , Nejm Mariana Bocca , Silva Sylvia Maria Affonso , Cravo Sergio L 
Published: February 2023

Abstract
OBJECTIVE: The effects of maternal obesity on fetal development are controversial. Our aim was to evaluate the effects of energy intake equalization during pregnancy on the maternal energy balance and fetal development.
METHODS: Female rats were mated 30 days following the bilateral lesion of ventromedial hypothalamus (VMH) divided into three groups: CONTROL (C) – false lesionated (sham) fed ad libitum; OBESE (OB) - lesionated fed ad libitum; OBESE PAIR-FED (OBP) - lesionated fed on the equalized C ingestion. Cesarean was made on the 20th day of pregnancy. Maternal and pups carcass, feces and food were submitted to calorimetric measurement for energy balance determination. Body composition and plasmatic levels of hormones and lipids were determined. Body weight, food intake and fat content were increased in obese animals following experimental lesion of the VMH.
RESULTS: During pregnancy, obese animals showed higher metabolizable energy intake and energy expenditure compared to the control and pair-fed animals, in which food-equalization reduced net body weight gain, metabolizable energy intake, energy gain, and gross food efficiency, compared to control and obese animals. Maternal obesity did not alter hormone and lipid profiles, body weight, energy content and body composition of the offspring, except for a reduction of lipid content in OBP newborns.
CONCLUSION: The results suggest that at birth the fetuses were preserved of deleterious effects of maternal obesity. Hence, unlike the expected, caloric equalization imposed during the gestational period to previously obese pregnant seems to exert negative effects on the offspring.
Simulation based Single cell and Multi Cell Monitoring Management with SOC &amp; SOH Control for Continuous working of Electric Vehicle/ Grid Connected System
Authors: V Kandaswamy K , B Raj Narain 
Published: February 2023

Abstract
Electric vehicles (EVs) and smart grids are two examples of high-power applications that frequently use lithium-ion pack and a battery management system (BMS). Battery status estimation, defect detection, monitoring, and control functions are required for BMS implementations, which require both software and hardware. Predicting battery life aids in the consistent and efficient operation of battery-powered equipment. The proposed method uses Portable and continuous monitoring of the battery life to prevent from sudden discharge, High temperature with frequent charging and discharging system. Voltage, current, and temperature sensors are used to detect the voltage, current, and temperature of the cells. The controller receives the data from each sensor connected at different node gives the update continuously to the monitor. Similarly, the controller prevents the battery from over discharge and under discharge of each cell. Apart from regular monitoring and controlling of each cell, a novel method is proposed in the existing circuit for partial or full charging during idling condition. Monitoring the battery state continuously allows for balanced charging of the battery cells and overcharge prevention. The suggested concept includes a Graphical User Interface (GUI), a method for training a model, and test results for the BMS.
Market Basket Analysis with Statistically Improved Association Rules Considering Product Details
Authors: Dogan Onur 
Published: February 2023

Abstract
E-commerce companies need to direct customers to choose the wished products. A significant challenge in the e-commerce domain forces to use of technology and data-oriented solutions. So, investigating the sales transactions is necessary thanks to the high number of product varieties for product recommendation. Although creating association rules with many algorithms is common, this study improves the traditional association rule mining (ARM) method by adding a different perspective, named statistical settings, to create more insights for managerial implications. After generating rules, it checks the statistical significance of the correlation, considering some product-specific details, such as product name, discount rates, and the number of favorites. The study concluded with exciting insights. For example, the company should recommend products with a lower discount rate if the customer puts products in the basket with a high discount rate. It also enriches traditional rules by adding product features. When the total number of favorites is less than 7500, and the discount rate is less than 75\%, the similarity ratio of the Conclusion products should be less than 0.50.
Pressure recovery model for gas-liquid two-phase flow across sudden expansions
Authors: Arabi Abderraouf , Abdul-Majeed Ghassan H. , Boukrouche Houari B. , Larbi Zakaria 
Published: February 2023

Abstract

The presence of a sudden expansion generates a variation of the static pressure commonly called Pressure Recovery (PR). In this paper, we made firstly an extensive literature survey to list existing gas-liquid two-phase flow pressure recovery models and to collect an experimental database. Thus, a total of 305 data was collected from 6 recent works and 18 predictive models was identified. An analysis of the different existing models was carried out firstly. Then, the predictive capability of nine existing models was assessed using the collected database. It was reported that none of the models can predict the experimental results for a large range of experimental conditions. This finding highlighted the necessity to propose a new model. The proposed predictive model was developed using the two-phase multiplier and mass quality. These two parameters were correlated using 157 data points from the collected database, while the other data was used to validate it. It was found that the proposed model gives better predictions compared to existing ones in the range of conditions and parameters of the experimental database used in this analysis.
Blocking the FAM19A5-LRRC4B complex enhances neurite growth and synapse assembly.
Authors: Seong Jae Young 
Published: February 2023

Abstract
Disruption in dynamic balance of synapse build-and-removal process is a major cause of neurological diseases, although the mechanisms underlying the brain fine-tunes and balances this process remain poorly understood. Here, we show that FAM19A5 binds to the postsynaptic adhesion molecule LRRC4B via the FAM19A5 binding (FB) domain, suppressing the interaction of LRRC4B with a presynaptic adhesion molecule PTPRF. Decoys with the FB domain bind to FAM19A5 and redirect it away from the FAM19A5-LRRC4B complex, promoting neurite growth and synapse formation of neurons. The anti-FAM19A5 monoclonal antibody NS101 breaks apart the FAM19A5-LRRC4B complex and enables the transfer of FAM19A5 from the brain into the bloodstream, leading to the restoration of synaptic integrity and improve cognitive function in mouse models of Alzheimer’s disease. Together, our findings suggest that blocking the complex with NS101 may offer therapeutic strategy for treating neurodegenerative diseases requiring regeneration of neurites and formation of new synapses.
Targeting Ion Channels for the Treatment of Glioma
Authors: Keluth Saritha , Jitte Srikanth , Bhushan Rashmi , Ranjan Om Prakash , Murti Krishna , Ravichandiran Velayutham , Kumar Nitesh 
Published: February 2023

Background:
Glioma refers to the most aggressive tumor in the central nervous system that
starts from support cells or glial cells. The glial cell is the most common cell type in the CNS, and
they insulate, surround, as well as feed, oxygen, and nutrition to the neurons. Seizures, headaches,
irritability, vision difficulties, and weakness are some of the symptoms. Targeting ion channels is particularly
helpful when it comes to glioma treatment because of their substantial activity in glioma genesis
through multiple pathways.

Objective:
In this study, we explore how distinct ion channels can be targeted for glioma treatment
and summarize the pathogenic ion channels activity in gliomas.

Results:
Current research found several side effects such as bone marrow suppression, alopecia, insomnia,
and cognitive impairments for presently done chemotherapy. The involvement of research on
ion channels in the regulation of cellular biology and towards improvements of glioma have expanded
recognition of their innovative roles.

Conclusion:
Present review article has expanded knowledge of ion channels as therapeutic targets and
detailed cellular mechanisms in the roles of ion channels in gliomas pathogenesis.
Polycaprolactone-based Nanocarriers Containing 5-fluorouracil as a
Therapeutic Guided Drug Delivery Approach for Enhancing Anticancer
Activity
Authors: Mohammadian Samaneh , Khazaei Majid , Maghami Parvaneh , Avan Amir , Rezaei Majid 
Published: February 2023

Abstract:
Nowadays, nano-platforms designed for drug delivery systems (DDSs) such as polymers,
liposomes, and micelles have been demonstrated to be clinically efficient. The sustained drug release is
one of the advantages of DDSs, especially polymer-based nanoparticles. The formulation could enhance
the drug's durability, in which the biodegradable polymers are the most interesting building
blocks of DDSs. Nano-carriers could circumvent many issues by localized drug delivery and release
via certain internalization routes such as intracellular endocytosis paths and increasing biocompatibility.
Polymeric nanoparticles and their nanocomposite are one of the most important classes of materials
that can be used for the assembly of nanocarriers that can form complex, conjugated and encapsulated
forms. The site-specific drug delivery may arise from the ability of nanocarriers to pass through the
biological barrier, their specific interactions with receptors, and passive targeting. The better circulation,
uptake, and stability along with targeting attributes lead to lesser side effects and damage to normal
cells. Hence, in this review, the most recent achievements on polycaprolactone-based or -modified
nanoparticles in drug delivery systems (DDSs) for 5-fluorouracil (5-FU) are presented.
Electrochemical Detection of Sulfadiazine by Sensors based on Chemically
Modified Carbon Electrodes: A Review
Authors: Ben Brahim Khalid Ait , Bendany Mohamed , El Hamdouni Youssra , Abbi Khaoula , Bakkouche Chaymae , Fattoumi Hatim , Hermouche Lina , Labjar Najoua , Dalimi Mohamed , El Hajjaji Souad 
Published: February 2023

Abstract:
The consumption of medicines (usually pharmaceuticals and chemical health products)
has increased in recent decades due to the demand for medicines for various diseases (headache,
relapsing fever, dental absence, streptococcal infection, bronchitis, ear and eye infections). Instead,
their overuse can lead to serious environmental damage. Sulfadiazine is one of the most often used
antimicrobial medications for both human and veterinary therapy, yet its presence in the
environment, even in low quantities, offers a potential concern as an emergency pollutant. It is vital
to have a monitoring that's quick, selective, sensitive, stable, reversible, reproducible, and easy to
use. Electrochemical techniques realizing cyclic voltammetry (CV), differential pulse voltammetry
(DPV), and square wave voltammetry (SWV), using a modified electrode based on carbon as a
surface modifier are an excellent option that makes control simple and quick owing to their cheap
cost and convenience of use, while also safeguarding human health from drug residue buildup.

:
This study discusses different chemically modified carbon-based electrodes such as graphene paste,
screen printed electrode, glassy carbon, and boron diamond doped electrodes for SDZ (sulfadiazine)
detection in various formulation feeds, pharmaceuticals, milk, and urine samples, the results
obtained also show high sensitivity and selectivity with lower detection limits compared to matrix
studies, which may explain its use in trace detection. Furthermore, the effectiveness of the sensors is
assessed by other parameters including buffer solution, scan rate, and pH. Also, a method for real
sample preparation was also discussed in addition to the different methods mentioned.