bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐Life Quasi‐Solid‐State Anode‐Free Batteries Enabled by Li Compensation Coupled Interface Engineering
Authors: Liu Yuzhao , Meng Xiangyu , Shi Yu , Qiu Jieshan , Wang Zhiyu 
Published: July 2023

AbstractInitially, anode‐free Li metal batteries present a promising power source that merges the high production feasibility of Li‐ion batteries with the superb energy capabilities of Li‐metal batteries. However, their application confronts formidable challenges of extremely short lifespan due to the inadequacy of zero‐Li‐excess cell configuration against irreversible Li loss. A Li compensation coupled interface engineering strategy is reported for realizing long‐life quasi‐solid‐state anode‐free batteries. The Li2S is utilized as a sacrificial Li supplement to effectively counterbalance irreversible Li loss without damage to cell chemistry. Meanwhile, it demonstrates remarkable efficacy in establishing a robust yet slender inorganic–organic hybrid solid‐state interphase for inhibiting cell degradation by dead and dendritic Li. This strategy enables quasi‐solid‐state anode‐free batteries with a long lifespan of 500 cycles. The Ah‐scale quasi‐solid‐state pouch cells, featuring a high‐loading LiFePO4 cathode and lean gel polymer electrolyte, exhibit a high specific energy of 300 Wh kgcell−1. This achievement translates into an improvement of 46% in gravimetric energy and 94% in volumetric energy compared to LiFePO4||graphite batteries while outperforming LiFePO4||Li‐metal batteries by 22–47% in volumetric energy. Such quasi‐solid‐state anode‐free cells also demonstrate good safety, showcasing remarkable resistance against nail penetration in ambient air without failure, smoke, or fire accidents.
Truncated TDP‐43 proteoforms diagnostic of frontotemporal dementia with TDP‐43 pathology
Authors: Forgrave Lauren M. , Moon Kyung‐Mee , Hamden Jordan E. , Li Yun , Lu Phoebe , Foster Leonard J. , Mackenzie Ian R. A. , DeMarco Mari L. 
Published: July 2023

AbstractINTRODUCTIONBiomarkers of TDP‐43 pathology are needed to distinguish frontotemporal lobar degeneration with TDP‐43 pathology (FTLD‐TDP) from phenotypically related disorders. While normal physiological TDP‐43 is not a promising biomarker, low‐resolution techniques have suggested truncated forms of TDP‐43 may be specific to TDP‐43 pathology. To advance biomarker efforts for FTLD‐TDP, we employed a high‐resolution structural technique to characterize TDP‐43 post‐translational modifications in FTLD‐TDP.METHODSHigh‐resolution mass spectrometry was used to characterize TDP‐43 proteoforms in brain tissue from FTLD‐TDP, non‐TDP‐43 dementias and neuropathologically unaffected cases. Findings were then verified in a larger cohort of FTLD‐TDP and non‐TDP‐43 dementias via targeted quantitative mass spectrometry.RESULTSIn the discovery phase, truncated TDP‐43 identified FTLD‐TDP with 85% sensitivity and 100% specificity. The verification phase revealed similar findings, with 83% sensitivity and 89% specificity.DISCUSSIONThe concentration of truncated TDP‐43 proteoforms—in particular, in vivo generated C‐terminal fragments—have high diagnostic accuracy for FTLD‐TDP.Highlights
Discovery: Truncated TDP‐43 differentiates FTLD‐TDP from related dementias.
Verification: Truncated TDP‐43 concentration has high accuracy for FTLD‐TDP.
TDP‐43 proteoforms <28 kDa have highest discriminatory power for TDP‐43 pathology.
Integrating Pillar[5]arene and BODIPY for a Supramolecular Nanoplatform To Achieve Synergistic Photodynamic Therapy and Chemotherapy
Authors: Quan Hui , Huang Yuying , Xia Jiacheng , Yang Jiawen , Lu Bing , Liu Peisheng , Yao Yong 
Published: July 2023

AbstractBODIPY photosensitizers have been integrated with a hypoxia‐activated prodrug to achieve synergistic photodynamic therapy (PDT) and chemotherapy. A novel BODIPY derivative BDP‐CN was designed and synthesized. It had two cyano groups to make it complex well with a water‐soluble pillar[5]arene. Their association constant was calculated to be (6.8±0.9)×106 M−1. After self‐assembly in water, regular spherical nanocarriers can be formed; these were used to encapsulate the hypoxia‐activated prodrug tirapazamine (TPZ). BDP‐CN displayed excellent photodynamic activity to complete PDT. In this process, O2 can be continuously consumed to activate TPZ to allow it to be converted to a benzotriazinyl (BTZ) radical with high cytotoxicity to complete chemotherapy. As a result, the formed nanoparticles showed excellent synergistic photodynamic therapy and chemotherapy efficacy. The synergistic therapy mechanism is discussed in detail.
Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics
Authors: Schiavi Simona , Palombo Marco , Zacà Domenico , Tazza Francesco , Lapucci Caterina , Castellan Lucio , Costagli Mauro , Inglese Matilde 
Published: July 2023

AbstractSoma and neurite density image (SANDI) is an advanced diffusion magnetic resonance imaging biophysical signal model devised to probe in vivo microstructural information in the gray matter (GM). This model requires acquisitions that include b values that are at least six times higher than those used in clinical practice. Such high b values are required to disentangle the signal contribution of water diffusing in soma from that diffusing in neurites and extracellular space, while keeping the diffusion time as short as possible to minimize potential bias due to water exchange. These requirements have limited the use of SANDI only to preclinical or cutting‐edge human scanners. Here, we investigate the potential impact of neglecting water exchange in the SANDI model and present a 10‐min acquisition protocol that enables to characterize both GM and white matter (WM) on 3 T scanners. We implemented analytical simulations to (i) evaluate the stability of the fitting of SANDI parameters when diminishing the number of shells; (ii) estimate the bias due to potential exchange between neurites and extracellular space in such reduced acquisition scheme, comparing it with the bias due to experimental noise. Then, we demonstrated the feasibility and assessed the repeatability and reproducibility of our approach by computing microstructural metrics of SANDI with AMICO toolbox and other state‐of‐the‐art models on five healthy subjects. Finally, we applied our protocol to five multiple sclerosis patients. Results suggest that SANDI is a practical method to characterize WM and GM tissues in vivo on performant clinical scanners.
Prevalence of diagnosed psychiatric disorders among adults who have experienced and internalized weight stigma
Authors: Pearl Rebecca L. , Hernandez Marian , Bach Caroline , Groshon Laurie , Wadden Thomas A. 
Published: July 2023

AbstractObjectiveExperiences and internalization of weight stigma are associated with greater self‐reported psychological distress and symptoms of psychiatric disorders such as depression and anxiety. However, little is known about the extent to which individuals who have experienced and internalized weight stigma are diagnosed with or provided treatment for psychiatric conditions. The current study aimed to characterize the prevalence of diagnosed psychiatric disorders among adults with obesity who had experienced and internalized weight stigma.MethodsWeight‐loss treatment‐seeking adults with a history of experiencing weight stigma and high levels of internalized weight stigma were recruited for two clinical trials.ResultsIn Study 1 (n = 84, 83.3% women, 67.9% Black), 25% of participants reported a lifetime history of a mood disorder. Few participants (<10%) reported current psychiatric diagnoses or use of psychiatric medications. In Study 2 (n = 129, 88.4% women, 65.1% white), one‐third of participants reported a mood disorder history, and 21.7% reported an anxiety disorder history, with approximately 16%–18% reporting current diagnoses. In both studies, few participants reported a history of a diagnosed eating disorder despite high rates of current full‐ or subthreshold symptoms. Based on Beck Depression Inventory‐II scores, approximately 54%–64% of participants reported mild or greater symptoms of depression.ConclusionsOverall, lifetime history of diagnosed psychiatric disorders and current symptoms of depression and eating disorders were relatively high across two samples. More research is needed to determine the impact of weight stigma on the diagnosis and treatment of eating disorders and other psychiatric concerns.
Teachers’ experience of the breakdown of infrastructures during the pandemic
Authors: Godhe Anna-Lena 
Published: July 2023

AbstractThis article reports on teachers’ experience of working during the Covid-19 pandemic. The analysis is based on a thematic analysis of group interviews with 76 teachers working throughout the Swedish school system, i.e., preschools, primary, secondary school, and municipal adult education. The interviews were conducted during autumn 2021. Conceptualizing teaching and working during the pandemic as a breakdown of infrastructures, the article focuses on how teachers talk about changes in institutional, social, technological, and pedagogical aspects of teaching and learning. The results show that changes in institutional aspects mainly concern teachers’ communication with colleagues, custodians, and school leadership. Social and pedagogical aspects are emphasized, while technological aspects are not as prominent in the teachers’ accounts. Commonly taken-for-granted aspects are brought to the fore, and their importance for teaching and learning has implications for the new normal and for what is of importance when creating future infrastructures for teaching and learning.
On the Felsenthal Power Index
Authors: Freixas Josep , Samaniego Dani 
Published: July 2023

AbstractThe paper that introduces the Felsenthal index is titled: ‘A well-behaved index of a priori P-Power for simple n-person games.’ In 2016, Felsenthal introduced his index for simple games. His definition does not base on the axiomatic approach. Then, Felsenthal regarded some properties and proved that his index satisfies a list of six reasonable and compelling postulates. Three of the properties that he regarded refer to the weighted games, but this fact does not reduce the definition of his index to weighted games. He proves that none of seven well-known efficient power indices proposed to date satisfies the list of postulates, indicating for each of them which of the six postulates violate. In this paper we extend some of his postulates, originally defined for weighted games, to simple games. The main objective of the article is to answer three open questions motivated in his article. In particular, we prove that his index may not be the unique one fulfilling the six proposed postulates, provide an axiomatic characterization for his index and, propose an impossibility result, which is obtained by adding a new postulate to a sublist of the postulates he considered. We also remark the existence of some alternative compelling postulates which are not satisfied for the index.
Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma
Authors: Yang Xinyu , Ji Chunxia , Qi Ying , Huang Jianhan , Hu Lang , Zhou Yuan , Zou Liping , Xia Yi , Tan Feng , Yao Yu , Chen Di 
Published: July 2023

Abstract
Background
Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma. Currently, microglia (CD11b+/CD45Low) and macrophages (CD11b+/CD45High) are distinguished as distinct cell types due to their different origins. Moreover, signal-transducing adaptor protein 1 (STAP1) plays a role in tumourigenesis and immune responses. However, to date, no studies have been reported on STAP1 in GAMs.

Methods
The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases were used to investigate the association between STAP1 mRNA levels and clinical parameters (grades, mutations in isocitrate dehydrogenase, and overall survival). RNA-sequencing, qRT-PCR, Western blotting, immunohistochemistry and immunofluorescence analyses were performed to detect the expression level of STAP1 and related proteins. BV-2 cells were used to construct a STAP1-overexpressing cell line. Phagocytosis of BV-2 cells was assessed by flow cytometry and fluorescence microscopy. C57BL/6 mice were used to establish orthotopic and subcutaneous glioma mouse models. Glioma growth was monitored by bioluminescence imaging.

Results
STAP1 expression in glioma-associated microglia is positively correlated with the degree of malignancy and poor prognosis of glioma. Moreover, STAP1 may promote M2-like polarisation by increasing ARG1 expression and inhibiting microglial phagocytosis of microglia. Increased ARG1 may be associated with the IL-6/STAT3 pathway. Impaired phagocytosis may be associated with decreased cofilin and filopodia.

Conclusion
STAP1 is positively associated with the degree of glioma malignancy and may represent a potential novel therapeutic target for glioma.
The Language of Compassion: A Few Lessons from Michigan Lawyers on How to Communicate Compassionately with Personal Injury Clients
Authors: Cudowska Maria 
Published: July 2023

AbstractThough judges and lawyers encourage claimants to settle disputes out of courts, lawyers may struggle managing out-of-court dispute resolution processes. Some of the dispute management struggles are related to emotions of clients. One of the reasons why it may be difficult to manage a client’s emotions is because out-of-court disputes require a different communication skillset from lawyers. The following note features some advice for law students on how to incorporate compassionate communication methods in personal injury disputes. Personal injury disputes may be emotionally challenging for clients. Such challenges may manifest in communication issues and prolonged suffering of clients. Yet, both students and academics may dismiss the importance of soft-skill development in due course of legal education. As lawyer-socialization institutions, law schools have a duty to foster skills that are necessary to successfully assist clients in emotionally challenging disputes. This contribution discusses the notion of human suffering and compassion-based counselling scholarship in relation to personal injury disputes. The paper advocates for normalizing emotions in personal injury disputes, and through testimonials of Michigan lawyers, presents real life examples of how lawyers can communicate compassionately with their clients. Law students can benefit from learning about real-life examples of communication patterns between lawyers and clients to have better conversations with their clients.
Diversity and Evolutionary History of Ti Plasmids of “tumorigenes” Clade of Rhizobium spp. and Their Differentiation from Other Ti and Ri Plasmids
Authors: Kuzmanović Nemanja , Wolf Jacqueline , Will Sabine Eva , Smalla Kornelia , diCenzo George C , Neumann-Schaal Meina 
Published: July 2023

Abstract
Agrobacteria are important plant pathogens responsible for crown/cane gall and hairy root diseases. Crown/cane gall disease is associated with strains carrying tumor-inducing (Ti) plasmids, while hairy root disease is caused by strains harboring root-inducing (Ri) plasmids. In this study, we analyzed the sequences of Ti plasmids of the novel “tumorigenes” clade of the family Rhizobiaceae (“tumorigenes” Ti plasmids), which includes two species, Rhizobium tumorigenes and Rhizobium rhododendri. The sequences of reference Ti/Ri plasmids were also included, which was followed by a comparative analysis of their backbone and accessory regions. The “tumorigenes” Ti plasmids have novel opine signatures compared with other Ti/Ri plasmids characterized so far. The first group exemplified by pTi1078 is associated with production of agrocinopine, nopaline, and ridéopine in plant tumors, while the second group comprising pTi6.2 is responsible for synthesis of leucinopine. Bioinformatic and chemical analyses, including opine utilization assays, indicated that leucinopine associated with pTi6.2 most likely has D,L stereochemistry, unlike the L,L-leucinopine produced in tumors induced by reference strains Chry5 and Bo542. Most of the “tumorigenes” Ti plasmids have conjugative transfer system genes that are unusual for Ti plasmids, composed of avhD4/avhB and traA/mobC/parA regions. Next, our results suggested that “tumorigenes” Ti plasmids have a common origin, but they diverged through large-scale recombination events, through recombination with single or multiple distinct Ti/Ri plasmids. Lastly, we showed that Ti/Ri plasmids could be differentiated based on pairwise Mash or average amino-acid identity distance clustering, and we supply a script to facilitate application of the former approach by other researchers.
Post-extubation use of high-flow nasal oxygenation induces upper airway leak and intrathoracic sepsis after successful Bentall procedure: A case report
Authors: Liao Yu-Yang , Wu Hsuan-Yin , Lam Chen-Fuh , Wang Yi-Ming 
Published: July 2023

Rationale:
In recent few years, high-flow nasal oxygenation (HFNO) has been widely used for management of acute hypoxemic respiratory failure and during postextubation periods, including after endotracheal intubation general anesthesia (ETGA). However, HFNO generates positive pressure in the injured airway following removal of endotracheal tube may cause airway leaks. This is the first case report of severe airway leak syndrome following postextubation use of HFNO in surgical patients.

Patient concerns:
This case report describes a 75-year-old female with critical aortic stenosis who underwent an emergency Bentall procedure. HFNO (flow rate of 45 L/min) was applied after weaning from mechanical ventilation and removal of the endotracheal tube.

Diagnoses:
At 6 hours after HFNO application, subcutaneous emphysema in the neck bilaterally and face was noted, and the emphysema extended into the supraclavicular regions.

Interventions:
The HFNO cannula was removed soon after and the patient was re-intubated with an endotracheal tube the following day due to progressive respiratory insufficiency. Unfortunately, the patient general condition deteriorated, as the subcutaneous air collections progressed into deep tissue infections of the neck, mediastinal abscesses, and left-sided empyema. Patient received surgical interventions repeatedly to drain the mediastinal abscess and empiric antimicrobial therapy was given.

Outcomes:
The patient passed away about 2 months later due to uncontrollable sepsis.

Lessons:
Air leaks in the upper airway can occur during the use of post-extubation HFNO use, and the resulting subcutaneous emphysema can progress to severe intrathoracic infections in surgical patients who have a sternotomy wound. Therefore, HFNO-induced subcutaneous emphysema should be treated more aggressively in open thoracic or sternotomy surgeries to prevent the development of intrathoracic sepsis.
Clinical analysis of three patients with multiple endometrial cancer lesions treated by hysteroscopic surgery combined with progesterone: Case report
Authors: Wang Li , Cong Rimin , Zhang Lili , Zhang Danni , Wu Juntong 
Published: July 2023

Rationale:
Endometrial cancer (EC) is one of three common malignant tumors of the female reproductive tract, exceeded by cervical cancer. It has an incidence rate ranging from 3% to 10% with an increasing trend in recent years.

Patient concerns:
To analyze the clinical effectiveness of hysteroscopic surgery combined with progesterone therapy in patients with multiple lesions of endometrial cancer with fertility preservation.

Diagnoses:
Multiple endometrial cancer lesions were present.

Interventions:
Three patients presented with menstrual cycle disorders, irregular vaginal bleeding, and endometrial thickening. Diffuse and local bulges of the endometrium can be seen under hysteroscopy. The histopathological results showed varying degrees of complex endometrial hyperplasia with canceration. Progesterone receptor was detected in lesion tissues through immunohistochemical examination.

Outcomes:
Case 1 fully recovered within 2 months, case 2 within 3 months, and case 3 within 9 months.

Lessons:
Our data suggested the clinical efficacy of hysteroscopic surgery combined with progesterone therapy in patients with early multiple endometrial cancer, providing the precious experience of the clinical presentation.
Pediatric Diving-Related Injuries in Swimming Pools Presenting to US Emergency Departments
Authors: Houlihan Nathan , Shah Ronit , Adams Alex , Talwar Divya , MacAlpine Elle M. , Weltsch Daniel , Mehta Nishank , Baldwin Keith , Ganley Theodore 
Published: July 2023

Objectives
Recreational swimming/diving is among the most common physical activities in US children and a significant cause of morbidity across the United States. This study updates the national epidemiology of diving-related injuries.

Methods
The Consumer Product Safety Commission's National Electronic Injury Surveillance System database was queried for patients aged 0 to 19 from 2008 to 2020 who presented to any of the 100 National Electronic Injury Surveillance System-participating emergency departments for a diving-related injury. Dive characteristics such as dive height, dive skill, dive direction, and dive sequence were determined from case narratives.

Results
A total of 1202 cases were identified for analysis corresponding to a total national estimate of 37,387 diving related injuries during the period from 2008 to 2020 and a national incidence of 3.6 injuries per 100,000 population. Males accounted for 64% of injuries. The average yearly incidences of injury in the 10 to 14 and 15 to 19 age groups were identical at 5.8 per 100,000. Contact with the diving board or platform was the most common cause of injury (34%). Diving backwards or attempting a flip or handstand dive were associated with increased odds of sustaining an injury resulting from contact with the diving board or platform (odds ratio, 16.0 and 6.9, respectively). In 2020, the incidence of diving-related injury fell to 1.6 per 100,000 population.

Conclusions
Diving injuries are common in children and adolescents, especially in boys aged 10 to 19. There was a significant reduction in diving-related injury corresponding with the COVID-19 pandemic.
Ocular Trauma in Children
Authors: Sharifi Ali , Parvaz Parinaz , Sharifi Hamid , Farsi Maryam , Akbari Zahra 
Published: July 2023

Objectives
This study aimed to determine the epidemiology of eye injuries in children and the influential factors involved.

Methods
Eighty cases of confirmed ocular trauma were included in this cross-sectional study. Data were obtained via a checklist containing demographic information, site of the insult, the interval between the injury and physician visit, trauma mechanism, and medical history, including previous history of ocular trauma.

Results
Among 80 children with ocular trauma, 72.5% (n = 58) were boys. A marked preponderance (46.2%) of injuries was seen in the age group younger than 6 years. The youngest patient was a 1-year-old, and the oldest was aged 17. Most (76.25%) of the incidents occurred indoors. A total of 67.5% of accidents were induced by sharp objects (knife and glass). Most accidents occurred in spring, whereas the least number of accidents occurred in winter. The corneoscleral laceration was the most common manifestation, followed by the laceration of the iris, uveal prolapse, hyphema, and cataracts. Furthermore, rare cases of retinal detachment, hypopyon, and corneal epithelial defects were seen.

Conclusions
The highest incidents of ocular trauma occurred in boys, especially those younger than 6 years. The high number of sharp object injuries is also concerning. These findings provide us with evidence that further educational interventions and supervision are required in these groups to minimize the possible devastating injuries before the opportunity even arises.