bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENENTUAN TIPE PINTU PADA DESAIN PERENCANAAN RUANG LABORATORIUM PT. BIO FARMA (PERSERO) BANDUNG
Authors: Rahma Kamila Fadila , . Utami 
Published: June 2023

Bio Farma (Persero) dalam menjalankan perusahaannya seiring berjalannya waktu akan terus mengupayakan perkembangan inovasi terbaru terutama dalam bidang farmasi. Salah satunya untuk mendukung kegiatan tersebut, maka PT. Bio Farma (Persero) membangun sebuah fasilitas baru yang diperuntukkan riset dan pengembangan sebuah produk. Tentunya dalam sebuah fasilitas riset pasti membutuhkan sebuah fasilitas laboratorium yang memadai untuk mewadahi kegiatan tersebut. Fasilitas sebuah laboratorium dikatakan baik ketika dalam operasional kegiatannya dilengkapi dengan sarana dan prasarana yang baik demi terjaganya keamanan dan keselamatan semua pihak yang terlibat di dalamnya, salah satunya yaitu dapat bersangkutan dengan aspek perencanaan sebuah desain arsitektural berupa penentuan tipe pintu yang baik untuk sebuah laboratorium. Dalam praktiknya penentuan sebuah pintu laboratorium harus mengacu kepada standar yang ada. Di dalam kajian ini bertujuan untuk mengetahui kriteria desain yang relevan untuk sebuah perencanaan laboratorium khususnya pada fasilitas gedung 34 milik PT. Bio Farma (Persero) dengan mengacu kepada standar dan rekomendasi desain yang nantinya akan digunakan sebagai fasilitas laboratorium untuk riset sebuah pengembangan produk. Metoda penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif yaitu dengan melakukan pengumpulan data objek studi penelitian serta literatur yang terkait dengan objek studi dan juga memperhatikan keterkaitan pengaruh standar terhadap rekomendasi yang dikeluarkan untuk menentukan tipe pintu yang tepat dan sesuai. Hasil dari analisis yang dilakukan oleh penulis terdapat 3 jenis desain pintu yang tepat dan relevan dengan berdasar pada standar acuan dan rekomendasi desain.
Phytochemical Screening and Antibacterial Activity of Chrysophyllum albidum Collected in Nsukka, South East Nigeria
Authors: Cyril Adonu, , Ibeabuchi Ali, , Romanus Omeh, 
Published: July 2023

Background: Chrysophyllum albidum is widely used by African people for the treatment of various types of diseases such as ear infection, sore throat, typhoid, cellulites, septicaemia, bactericemia, abscesses and tooth infections.
Aim: The study was conducted to investigate the chemical components and antibacterial activity of the extract and fractions from the root bark of Chrysophyllum albidum from Nsukka, South-east Nigeria.
Methodology: The fresh roots were collected, washed, cut into small pieces, air dried and pulverized to powder using mechanical grinder. Extraction and fractionation were done by cold maceration method and technique of liquid–liquid extraction respectively. The phytochemical analysis of the methanol extract and, n-hexane, butanol, aqueous and ethylacetate fractions of the plant part was carried out using standard method. The antibacterial activities were determined using cup-plate agar diffusion and agar dilution methods.
Results: The phytochemical screening of the extract revealed the presence of tannins, flavonoids, saponins, terpenoids, alkaloids, reducing sugar and cardiac glycosides. The inhibition zone diameter (IZD) produced by the agents against some selected Gram positive bacteria (GPB) and Gram negative bacteria (GNB) pathogens ranged from 6 – 25 mm and 6 – 12 mm respectively. The MIC and MBC values produced by the extract and fractions of the plant’s part against the GPB ranged from 1.25 – 40 mg/ml and 5 – 80 mg/ml respectively Many of the GNB were not sensitive to the agents tested except Pseudomonas aeruginosa and Klebsiella spp that exhibited mild to moderate sensitivity to the agents.
Conclusion: These agents, therefore, exhibited a potent antibacterial activity against all the GPB and a few GNB pathogens tested due to their potent phytochemicals. The results of this work have corroborated the trado-medical use of root of Chrysophyllum albidum for treating ear infection, sore throat, typhoid, cellulites, septicaemia, bactericemia, boils and tooth infection/decay.
Identification of Superior Genotypes for Yield and Quality in Multiplier Onion
Authors: Jeevitha D. , Umesh B. C. , Shashidhar T. R. , Patil Laxmi 
Published: July 2023

Background: Multiplier onion is one of the most important crops of Tamil Nadu. It is having lot of health benefits like anti-inflammatory, anti cholesterol, anticancer and antioxidant properties, lowering the toxigenicity of oils. It also shows chemo preventive effects and lowers down the risk of effect on gastric cancer. Considering the importance of multiplier onion an attempt was made to evaluate the multiplier onion genotypes to identify the best yielding genotype.
Methods: Seven genotypes of multiplier onion (Allium cepa var aggregatum) were evaluated under Northern transitional zone of Karnataka at University of Agricultural Sciences, Dharwad both during Kharif and Rabi for yield and quality parameters.
Results: The outcome of the experiment revealed that over the seasons, the genotype MP16-24 was registered highest total yield (167.86 q/ha), marketable yield (160.41q/ha), TSS (15.41), average bulb weight (4.64g)and less number of bolters, low infestation of thrips (7.83) and purple blotch (7.66). Therefore, the genotype MP 16-24 can be commercially grown under Dharwad conditions during both Kharif and Rabi because of its favorable characters.
Proficiency Level and Challenges in Economics of Grade 10 Students in Selected Public Schools in Central Philippines
Authors: Quirao Zarla D. , Bual Joel M. , Madrigal Dennis V. 
Published: June 2023

Aims: This paper assessed the level of proficiency in Economics of Grade 10 students in selected public schools in the Philippines during the school year 2022 in the areas of basic concepts of Economics, microeconomics, macroeconomics, and sectors of the economy and its policies when taken as a whole and grouped according to sex and grades. It also identified the challenges encountered by students in learning Economics. Lastly, it determined the difference in their proficiency level in Economics when grouped into demographics.
Place and Duration of Study: The study was conducted among Grade 10 junior high school students in Central Philippines during 2022.
Study Design: The study utilized the quantitative design, particularly the descriptive-comparative approach.
Methodology: The study was responded to by 304 stratified randomly sampled students using a validated and reliability-tested researcher-made test questionnaire and checklist. In assessing the study, it utilized the scale in ascending order: beginning, developing, approaching proficiency, proficiency, and advanced. In data analysis, mean, standard deviation, frequency count, percentage, rank, Mann-Whitney, and Kruskal Wallis were used.
Results: Generally, the student's proficiency level in Economics (M=24.25; SD=6.43) was rated as approaching proficiency. The low areas with approaching proficiency ratings that need improvement are microeconomics (M=5.33; SD=2.02), macroeconomics (M=7.58; SD=2.84), and sectors of the economy and its policies (M=3.82; SD=1.71). Regarding the demographics, according to sex, the Economics proficiency of female (M=25.18; SD=6.11) and male (M=23.22; SD=6.64) students was approaching proficiency. Meanwhile, the student's proficiency level with a grade of 90-100 (M=27.02; SD=5.82) was proficient compared to other grades, 85-90 (M= 23.18; SD=6.64), 80-84 (M= 22.05; SD= 5.58), and 75-79 (M=22.17; SD= 3.66) which were approaching proficiency. On the one hand, the findings showed a significant difference in their proficiency level in Economics when grouped according to sex [U=9547.5, p=0.010] and grades in Economics [χ2(3) =31.377, p=0.000]. Lastly, grade 10 students encountered challenges in learning Economics regarding teacher, student, learner environment, resources, facilities, and subject factors.
Conclusion: The findings imply a continuous improvement in instruction and the importance of programs and activities that encourage acquiring and developing proficiency in Economics. With the sustainable improvement in instruction intact, the student's proficiency in Economics is ensured.
Medicaid and the Promise for Cure
Authors: Miller Sophie Cain , Dar Mohammad H. , Finnell S. Maria E. , Fish Douglas G. , Cogle Christopher R. 
Published: January 2025

ImportanceCell and gene therapies are revolutionizing the treatment landscape for children and adults with rare diseases and can be life-changing for patients and their families. Successful implementation of these new therapies into clinical practice depends on their accessibility and affordability, particularly through publicly funded Medicaid agencies, which cover many children and adults with rare diseases.ObjectiveTo provide a framework to broadly assess cell and gene therapies, evaluate payment options, and ensure equitable access through the lens of publicly funded Medicaid programs.Evidence ReviewThis review draws on peer-reviewed articles, federal reports, and other relevant publications as well as the expertise of chief medical officers and medical directors of state Medicaid agencies across 5 diverse states.FindingsTwenty-nine articles and other references provide the foundation for this review. The recommendations presented focus on thoughtful implementation of cell and gene therapies, including policy recommendations in the domains of safety, effectiveness, population health, access, and budget.Conclusions and RelevanceProposed health care policy changes are intended to balance innovation, affordability, and equitable access for children and adults with rare diseases.
Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endothelium
Authors: Zavoriti Aliki , Miossec Pierre 
Published: January 2025

ObjectiveInflammation drives cardiovascular disease in rheumatoid arthritis (RA). Treatment with tofacitinib, a JAK1/JAK3 inhibitor, is associated with increased cardiovascular events in patients with RA. Here, we determined its effects on cytokine production during interactions between immune cells at the synovial and vascular levels and its impact on endothelial activation and coagulation during inflammation.MethodsActivated human peripheral blood mononuclear cells (PBMCs) were cocultured with RA synoviocytes or endothelial cells (ECs) mimicking the cellular interactions in synovium and vessels responsible for cytokine production. A dose‐response of tofacitinib was tested on interferon γ, interleukin (IL) 17A, IL‐10, IL‐6, and IL‐1β, and cytokine production was measured by enzyme‐linked immunosorbent assay at 48 hours. Endothelial activation was induced with IL‐17A and tumor necrosis factor (TNF) or on contact with PBMCs. Shortly after tofacitinib treatment, the expression of EC activation markers, specifically IL‐6, IL‐8, vascular cell adhesion molecule 1 (VCAM‐1), and E‐selectin, and of coagulation, including tissue factor and thrombomodulin, was assessed by real‐time polymerase chain reaction.ResultsTofacitinib differentially inhibited production of IFNɣ, IL‐17A, and IL‐10 from PBMC cocultures with RA synoviocytes or ECs (all P < 0.001). In cocultures with ECs, tofacitinib reduced further IL‐6 and IL‐8 production (both P < 0.001). In ECs activated by TNF/IL‐17A or indirectly via contact with activated PBMCs, tofacitinib decreased IL‐6 upregulation but not that of IL‐8, E‐selectin, or tissue factor. Thrombomodulin was significantly decreased. VCAM‐1 was greatly induced with a higher dose of tofacitinib in ECs incubated directly with added inflammatory cytokines (P < 0.05) or released by interaction with activated PBMCs (P < 0.001).ConclusionTofacitinib inhibits synovium and vascular inflammation but fails to prevent the prothrombotic effects of inflammatory cytokines on ECs.
Enhanced Near‐Infrared Amplified Spontaneous Emission and Stability Improvement of Air‐Processed Pure Black‐Phase Formamidinium Lead Iodide Perovskite Films
Authors: Yang Jun , Zeng Xin , Meng Zhen , Liu Hongfang , Pi Mingyu , Huang Yexiong , Li Shuaiqi , Yang Jie , Yu Peng , Liu Xinfeng , Fu Shencheng , Zhang Dingke 
Published: January 2025

AbstractFormamidine lead halide perovskite material is regarded as a competitive candidate for light amplification and lasers due to its ideal bandgap range and excellent optical properties. The formamidinium perovskites undergo a cubic‐to‐hexagonal transition in humid conditions, leading to the formation of yellow δ‐phase FAPbI3, which degrades laser device performance and stability. To address this, we propose using methylamine formate (MAFa) as an ionic liquid solvent for stable black‐phase α‐FAPbI3 perovskite films. Compared to traditional N, N‐dimethylformamide (DMF) solvent (FAPI‐DMF), FAPI‐MF films show improved ASE performance with lower threshold and higher gain under nanosecond laser excitation. Temperature‐dependent photoluminescence (PL) and transient absorption (TA) spectra reveal higher exciton binding energy (72.9 meV) and longer optical gain lifetime for FAPI‐MF films, attributed to the vertical arrangement of lead iodide in nano‐sized ion channels that promote α‐FAPbI3 formation. The FAPI‐MF films also exhibit excellent photostability, thermal stability, and resistance to humidity, ensuring continuous laser and long‐term stability. This work extends the perovskite family’s spectral range from visible to near‐infrared light, offering a color‐tunable emitter with broad applications, including chemical analysis, biomedical research, and food safety testing.
Hierarchical rGO‐Based Triboelectric Sensors Enable Motion Monitoring and Trajectory Tracking
Authors: Liu Sheng , Qing Weiming , Zhang Jiacheng , Liao Sihua , Wang Qiong , Wei Kexiang , Yan Wenyuan , Zhao Linchuan , Zou Hongxiang 
Published: January 2025

AbstractFlexible sensors are increasingly recognized for their transformative potential in wearable electronic devices, medical monitoring, and human‐computer interaction. Despite the advancements, developing a flexible sensor array with a simple structure and large area preparation for effective signal sensing and monitoring capabilities remains challenging. In this study, a hierarchical rGO‐based flexible triboelectric sensor (HG‐FTS) is scalably prepared by a simple blade‐coating approach, in which the nitrogen‐doped reduced graphene oxide (rGO) sheet is hierarchically deposited in a polydimethylsiloxane (PDMS) layer. The flexible triboelectric sensor performed in single electrode mode not only demonstrates exceptional reliability and consistency but also achieves a maximum voltage of ≈129 V and a power density of ≈0.5 W m−2. These characteristics enable the real‐time monitoring of human physiological signals and joint motion with high fidelity. Furthermore, an intelligent human‐computer interactive control system is developed using the HG‐FTS, featuring a digital array touch screen with a rectangular pattern. The build system can be successfully used for pressure sensing, object shape recognition, and trajectory tracking. This work provides a viable solution to the large area preparation and high‐performance flexible sensor manufacturing and demonstrates the potential application of HG‐FTS in human‐computer interaction, signal monitoring, and intelligent sensing.
Enhancing Selectivity of Two‐Dimensional Materials‐Based Gas Sensors
Authors: Yang Jiefu , Sun Ruijia , Bao Xuan , Liu Juanjuan , Ng Jun Wen , Tang Bijun , Liu Zheng 
Published: January 2025

AbstractTwo‐dimensional (2D) materials have emerged as promising candidates for gas sensing applications due to their exceptional electrical, structural, and chemical properties, which enable high sensitivity and rapid response to gas molecules. However, despite their potential, 2D material‐based gas sensors face a significant challenge in achieving adequate selectivity, as many sensors respond similarly to multiple gases, leading to cross‐sensitivity and inaccurate detection. This review provides a comprehensive overview of the recent advancements for improving the selectivity of 2D gas sensors. It explores material modification strategies, such as functionalizing the sensing components and tuning adsorption dynamics, to enhance selective gas interactions. Engineering approaches, including field‐effect modulation and sensor array design, are also discussed as effective methods to fine‐tune sensor performance. Additionally, the integration of machine learning (ML) algorithms is highlighted for their potential to differentiate among multiple analytes. Prospects for further improving selectivity through material optimization, sensor calibration, and drift compensation are explored, along with the incorporation of smart sensing systems into the Internet of Things (IoT). This review outlines key objectives and strategies that pave the way for next‐generation gas sensors with enhanced selectivity, reliability, and versatility, poised to impact a wide range of applications from environmental monitoring to industrial safety.
Phase‐Transfer Catalyst for Lithium‐Oxygen Batteries Based on Bidirectional Coordination Catalysis: 2‐Aminopyridine
Authors: Huang Mengyao , Wang Nan , Xie Mengran , Fu Yaning , Li Zhongjun , Lu Youcai , Liu Qingchao 
Published: January 2025

AbstractLi‐O2 batteries are considered promising candidates for next generation high energy storage systems due to their exceptionally theoretical energy density. However, the accumulation of insulating discharge product Li2O2 leads to severe cathode passivation, reduced conductivity, and hindered charge transfer, which seriously compromise the battery performance. This work proposes a novel phase‐transfer catalyst with bidirectional coordination functionality, 2‐aminopyridine (AP). The AP molecule contains a nucleophilic pyridine nitrogen and an electrophilic amino hydrogen, which can interact with Li+ and reactive oxygen intermediates through electrostatic attraction and hydrogen bonding, respectively. This dual interaction facilitates the liquid‐phase deposition of Li2O2 while enabling efficient product decomposition. The uneven electrostatic potential distribution within the AP molecule generates an internal electric field that stabilizes reduced oxygen species, shields against nucleophilic attacks, and suppresses Li+ deposition at the anode tips, effectively preventing lithium dendrite growth. Therefore, Li‐O2 batteries with AP exhibit an exceptionally high discharge capacity of 36419 mAh g−1, a significantly reduced charge over‐potential of 0.29 V, and an extended cycle life exceeding 2256 h. Through functional molecular structure design, the bidirectional coordination catalytic effect demonstrated by AP molecules effectively regulates the migration and interaction of substances during reactions, significantly improves the electrochemical performance of Li‐O2 batteries.
Adaptable, Dynamic, and Superhydrophobic Standing‐Fiber Surface with Muti‐Level Energy Barrier for Anti‐Icing
Authors: Lyu Pei , Shi Wenwen , Liu Yuemei , Ding Rui , Hu Jun , Shang Bin , Pan Heng , Ren Jie , Liu Xin , Xu Weilin 
Published: January 2025

AbstractPassive deicing technologies achieved by dynamic superhydrophobic surfaces and slippery substances contribute to widely used anti‐icing. However, the constant status of microstructures cannot cater to the changing environment, meanwhile, the energy barrier needs to be improved. Here, a dynamic superhydrophobic standing‐fiber surface with a three‐level energy barrier is fabricated by electrical flocking technology, which directly utilizes the wind field to assist anti‐icing. The standing‐fiber surface has low ice adhesion of 2.7 kPa, a high water contact angle of 171.1°, and a long icing delay time of 859 s under −30 °C. The superhydrophobicity contributes to excellent water repellency with a droplet retracting and bouncing distance of 3.53 and 3.75 mm. In the wind field at 9 ms−1, the inclined standing‐fiber surface theoretically accelerates the motion of the water droplet by 1.5 times compared with the lying‐fiber surface. The difference in thermal conductivity between the front and back sides of the standing‐fiber surface makes it an ideal candidate for designing anti‐icing, deicing, and thermal insulation clothes.
Amorphous Ga2O3 Semiconductor: A New Solution for Robust X‐Ray Dosimeters
Authors: Shao Hang , Zou Jiahao , Liang Huili , Zhu Rui , Zhang Yonghui , Zhan Xiaozhi , Zhu Tao , Zhang Jihua , Li Yuan , Zhang Guangyu , Mei Zengxia 
Published: January 2025

AbstractAs most commonly used miniature solid‐state dosimeter, metal‐oxide‐semiconductor field effect transistors (MOSFETs) have been facing unavoidable gate leakage and robustness problems due to the double‐sided role of traps in oxide insulators. Herein, a new solution for X‐ray dosimeter has been proposed which leverages the conductivity change of amorphous Ga2O3 (a‐Ga2O3) channel instead of charge trapping in oxide insulators. Increasingly negatively‐shifted threshold voltage (Vth) of a‐Ga2O3 thin‐film transistor is recorded together with almost unchanged subthreshold swing (SS) and field‐effect mobility (µFE) after X‐ray irradiations. X‐ray‐induced‐variation of oxygen vacancy (VO) related defects in a‐Ga2O3 is revealed after a combined investigation of X‐ray photoelectron spectroscopy (XPS) and neutron reflectivity (NR) measurements, contributing to the indicative Vth shift related with X‐ray dosage. A functional recovery is realized through an annealing process in air condition, showing the high reliability of a‐Ga2O3 semiconductor. Moreover, the unique merit of no need for power supply during X‐ray irradiations, beneficial from the slow neutralization rate of ionized VO related defects, imparts an offline working capability to the dosimeter. This work provides a potential strategy to monitor X‐ray dosage via utilizing the X‐ray‐induced change of amorphous oxide semiconductor conductivity, hence addressing the reliability and repeatability issues in present MOSFET devices.
Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels
Authors: Han Yibo , Liu Shuaiyuan , Ochieng Ben Omondi , Gu Yuanrui , Kong Lingwen , Wang Guixue , Ye Zhiyi 
Published: January 2025

AbstractDecellularized artificial blood vessels prepared using physical and chemical methods often exhibit limitations, including poor mechanical performance, susceptibility to inflammation and calcification, and reduced patency. Cross‐linking techniques can enhance the stiffness, as well as anti‐inflammatory and anti‐calcification properties of decellularized vessels. However, conventional cross‐linking methods fail to effectively alleviate residual stress post‐decellularization, which significantly impacts the patency and vascular remodeling following the implantation of artificial vessels. This study enhances vascular residual stress through varied conditions of proanthocyanidin (PC) cross‐linking on decellularized vessels. Microstructural analysis and mechanical investigations across various scales of fresh, decellularized, and residual stress‐recovered vessels are performed using atomic force microscopy (AFM), scanning electron microscopy (SEM), and uniaxial tensile testing. Results demonstrate substantial alterations in the morphology of elastic and collagen fibers post‐decellularization, which remarkably resemble fresh vessels following residual stress recovery. Furthermore, both the micro‐ and macro‐mechanical characteristics of vessels post‐residual stress recovery, including Young's modulus, viscoelasticity, and adhesion, closely resemble those of fresh vessels. Finite element modeling (FEM) confirms the distribution of residual stress and its role in enhancing vascular mechanical integrity. This experimental investigation provides a theoretical foundation at both micro and macroscopic levels for the development of biomimetic blood vessels.