bluuebunny/crossref_metadata_2025_split huggingface dataset:
Witches on Screen
Authors: Bléourt Willem de 
Published: February 2023

Abstract
It is often from films and television that people today get their visual stereotypes of witches, particularly from programmes for children, which in turn, often derive from children’s books. The deeply ingrained stereotype of the ‘old hag’ is still influential, but film and television have portrayed modern manifestations of witchcraft in diverse ways that reflect other themes explored in this book. The influence of Wicca shaped cinematic portrayals of covens. The Wicker Man is a good example of this and other such Wiccan motifs. Fascination with African traditions fed into the 1966 British Hammer Horror film The Witches. The attractive female witch also plays a prominent role in film and television, from Bewitched in the 1960s to the contemporary ‘teen witch’ genre. This chapter explores the influences on screen portrayals of witches past and present, and how film and television have shaped public understanding.
The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply
Authors: Durand Mickaël , Brehaut Virginie , Clement Gilles , Kelemen Zsolt , Macé Julien , Feil Regina , Duville Garry , Launay-Avon Alexandra , Roux Christine Paysant-Le , Lunn John E , Roudier François , Krapp Anne 
Published: February 2023

AbstractNitrate signaling improves plant growth under limited nitrate availability and, hence, optimal resource use for crop production. Whereas several transcriptional regulators of nitrate signaling have been identified, including the Arabidopsis thaliana transcription factor NIN-LIKE PROTEIN7 (NLP7), additional regulators are expected to fine-tune this pivotal physiological response. Here, we characterized Arabidopsis NLP2 as a top-tier transcriptional regulator of the early nitrate response gene regulatory network. NLP2 interacts with NLP7 in vivo and shares key molecular features such as nitrate-dependent nuclear localization, DNA-binding motif, and some target genes with NLP7. Genetic, genomic, and metabolic approaches revealed a specific role for NLP2 in the nitrate-dependent regulation of carbon and energy-related processes that likely influence plant growth under distinct nitrogen environments. Our findings highlight the complementarity and specificity of NLP2 and NLP7 in orchestrating a multitiered nitrate regulatory network that links nitrate assimilation with carbon and energy metabolism for efficient nitrogen use and biomass production.
Non-monotonic behavior of the Binder parameter in discrete spin systems
Authors: Watanabe Hiroshi , Motoyama Yuichi , Morita Satoshi , Kawashima Naoki 
Published: February 2023

Abstract
We study a non-monotonic behavior of the Binder parameter, which appears in discrete spin systems. We show that the Binder parameters of the Potts model are non-monotonic for q = 3 and 4, while they are monotonic for the Ising case (q = 2). Using the Fortuin–Kasteleyn graph representation, we find that the improved estimator of the Binder parameter consists of two terms with values only in the high- and low-temperature regions. The non-monotonic behavior is found to originate from the low-temperature term. With the appropriately defined order parameter, we can reduce the influence of the low-temperature term and, as a result, the non-monotonic behavior can also be reduced. We propose new definitions for the order parameter, which reduces or eliminates the non-monotonic behavior of the Binder parameter in a system for which the improved estimator of the Binder parameter is unknown.
How Does Corporate Governance Affect Equity Volatility? Worldwide Evidence and Theory
Authors: Gagnon Louis , Jeanneret Alexandre 
Published: February 2023

Abstract
We investigate the causal impact of corporate governance on equity volatility in a quasi-natural experimental setting by exploiting the staggered passage of governance reforms in the past 25 years. Using a sample of 33,831 firms from 48 countries, we find that equity volatility drops by one-fifth following the passage of reforms that increase board independence. This effect is driven by an adjustment in fixed operating costs as managerial expropriation decreases, rather than by changes in firms’ investments, profitability, asset risk, or financing decisions. We rationalize these findings with a model in which minority shareholders are subject to sticky managerial expropriation. (JEL G12, G32, G34)
Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study
Authors: Fakih Olivier , Desmarets Maxime , Martin Bérenger , Prati Clément , Wendling Daniel , Monnet Elisabeth , Verhoeven Frank 
Published: February 2023

Abstract

Objectives
The objectives of this study were to describe the incidence of major adverse cardiovascular events (MACEs) in French patients newly benefiting from the French Long-term Illness scheme (LTI) for AS and to evaluate the effect of various treatments on the risk of MACE occurrence.

Methods
This national cohort study was based on the French national medico-administrative database SNDS containing data on hospitalization, the LTI, and outpatient care consumption. All French patients newly receiving LTI benefits for AS from 2010 to 2013 were included. The final follow-up date was 31 December 2018. The occurrences of MACEs [stroke and myocardial infarction (MI)] and comorbidities were identified from algorithms previously described in the literature. Competitive risk analysis using propensity score and inverse weighting was performed to calculate cumulative incidence functions and to determine subhazard ratios (SHRs) for the various treatments of interest.

Results
Between 2010 and 2013, 22 929 patients were included [mean age 43.0 (s.d. 13.9) years, 44.9% mal]. The 8-year cumulative incidences of MACE, stroke, and MI were 1.81% (1.61–2.05), 0.97% (0.83–1.14), and 0.85% (0.71–1.04), respectively. NSAIDs [SHR: 0.39 (0.32–0.50), P &lt; 0.001] and anti-TNF [SHR 0.61 (0.46–0.80), P &lt; 0.001], but not anti-IL17 [2.10 (0.79–5.57)] were associated with a lower risk of MACE occurrence.

Conclusion
MACE incidence rates at 8 years are low in patients newly benefiting from LTI for AS. Our results support the hypothesis of a protective role of NSAIDs and anti-TNF in cardiovascular risk in these patients.
Symptoms of Attenuated Psychosis Syndrome in Relatives of Clinical High-Risk Youth: Preliminary Evidence
Authors: Tarbox-Berry Sarah I , Walsh Barbara C , Pogue-Geile Michael F , Woods Scott W 
Published: February 2023

Abstract

Background and Hypothesis
Attenuated Psychosis Syndrome (APS) impacts functioning and predicts increased risk of psychosis. Risk for developing APS itself has received minimal attention. Knowledge of familial and environmental contributions to APS symptoms would advance understanding of APS and risk for psychosis. As an initial step, this report presents the first data on APS symptoms in family members of APS patients.

Study Design
This study utilized a discordant sibling-pair family study design. The Structured Interview for Psychosis-risk Syndromes (SIPS) was administered to 17 APS probands and 26 non-APS biological siblings. Probands and siblings were compared on positive, negative, disorganized, and general SIPS symptom scales and factors derived from those scales.

Study Results
There was significantly greater symptom severity in probands compared to siblings on nine of 19 SIPS scales. Negative/anxiety, functioning, and positive symptom factors were identified. Probands showed significantly greater severity than siblings on the negative/anxiety and positive factors. Elevated pathology on the negative/anxiety factor best differentiated between probands and siblings, over and above the contribution of the positive factor. No difference was found for the functioning factor.

Conclusions
Results support the importance of non-familial effects on risk for APS and suggest differences in familial contribution to APS symptoms. Understanding the relative contribution of familial and environmental effects on APS symptoms may reveal important differences among APS patients, with implications for risk characterization, symptom course, and treatment selection.
Effects of donor source on transcriptomic profiles of human kidney tissue
Authors: Arat Seda , Huynh Renee , Kumpf Steven , Qian Jessie , Shoieb Ahmed , Virgen‐Slane Richard , Voigt Frank , Xie Zhiyong , Jakubczak John L. 
Published: February 2023

AbstractNormal human tissue is a critical reference control in biomedical research. However, the type of tissue donor can significantly affect the underlying biology of the samples. We investigated the impact of tissue donor source type by performing transcriptomic analysis on healthy kidney tissue from three donor source types: cadavers, organ donors, and normal‐adjacent tissue from surgical resections of clear cell renal cell carcinomas, and we compared the gene expression profiles to those of clear cell renal cell carcinoma samples. Comparisons among the normal samples revealed general similarity, with notable differences in gene expression pathways involving immune system and inflammatory processes, response to extracellular stimuli, ion transport, and metabolism. When compared to tumors, the transcriptomic profiles of the normal adjacent tissue were highly similar to the profiles from cadaveric and organ donor tissue samples, arguing against the presence of a field cancerization effect in clear cell renal cell carcinoma. We conclude that all three normal source types are suitable for reference kidney control samples, but important differences must be noted for particular research areas and tissue banking strategies.
Patient Outcomes and Unit Composition With Transition to a High-Intensity ICU Staffing Model: A Before-and-After Study
Authors: Proper Jennifer L. , Wacker David A. , Shaker Salma , Heisdorffer Jamie , Shaker Rami M. , Shiue Larissa T. , Pendleton Kathryn M. , Siegel Lianne K. , Reilkoff Ronald A. 
Published: February 2023

IMPORTANCE:
Provider staffing models for ICUs are generally based on pragmatic necessities and historical norms at individual institutions. A better understanding of the role that provider staffing models play in determining patient outcomes and optimizing use of ICU resources is needed.

OBJECTIVES:
To explore the impact of transitioning from a low- to high-intensity intensivist staffing model on patient outcomes and unit composition.

DESIGN, SETTING, AND PARTICIPANTS:
This was a prospective observational before-and-after study of adult ICU patients admitted to a single community hospital ICU before (October 2016–May 2017) and after (June 2017–November 2017) the transition to a high-intensity ICU staffing model.

MAIN OUTCOMES AND MEASURES:
The primary outcome was 30-day all-cause mortality. Secondary outcomes included in-hospital mortality, ICU length of stay (LOS), and unit composition characteristics including type (e.g., medical, surgical) and purpose (ICU-specific intervention vs close monitoring only) of admission.

RESULTS:
For the primary outcome, 1,219 subjects were included (779 low-intensity, 440 high-intensity). In multivariable analysis, the transition to a high-intensity staffing model was not associated with a decrease in 30-day (odds ratio [OR], 0.90; 95% CI, 0.61–1.34; p = 0.62) or in-hospital (OR, 0.89; 95% CI, 0.57–1.38; p = 0.60) mortality, nor ICU LOS. However, the proportion of patients admitted to the ICU without an ICU-specific need did decrease under the high-intensity staffing model (27.2% low-intensity to 17.5% high-intensity; p < 0.001).

CONCLUSIONS AND RELEVANCE:
Multivariable analysis showed no association between transition to a high-intensity ICU staffing model and mortality or LOS outcomes; however, the proportion of patients admitted without an ICU-specific need decreased under the high-intensity model. Further research is needed to determine whether a high-intensity staffing model may lead to more efficient ICU bed usage.
Application of decellularization-recellularization technique in plastic and reconstructive surgery
Authors: Shang Yujia , Wang Guanhuier , Zhen Yonghuan , Liu Na , Nie Fangfei , Zhao Zhenmin , Li Hua , An Yang 
Published: February 2023

Abstract
In the field of plastic and reconstructive surgery, the loss of organs or tissues caused by diseases or injuries has resulted in challenges, such as donor shortage and immunosuppression. In recent years, with the development of regenerative medicine, the decellularization-recellularization strategy seems to be a promising and attractive method to resolve these difficulties. The decellularized extracellular matrix contains no cells and genetic materials, while retaining the complex ultrastructure, and it can be used as a scaffold for cell seeding and subsequent transplantation, thereby promoting the regeneration of diseased or damaged tissues and organs. This review provided an overview of decellularization-recellularization technique, and mainly concentrated on the application of decellularization-recellularization technique in the field of plastic and reconstructive surgery, including the remodeling of skin, nose, ears, face, and limbs. Finally, we proposed the challenges in and the direction of future development of decellularization-recellularization technique in plastic surgery.
miR-124 Exacerbates depressive-like behavior by targeting Ezh2 to induce autophagy
Authors: Zeng Duan , Shi Yue , Li Siyuan , Xu Feikang , Zhu Weimin , Li Huafang , He Shen , Yuan Qianfa 
Published: February 2023

Background
On the basis of our previous research, miR-124 and autophagy have been shown to be associated with depression and antidepressant treatment, respectively. However, whether miR-124 is involved in depressive-like behavior and antidepressant efficacy through regulating autophagy remains poorly understood.

Methods
The chronic unpredictable mild stress (CUMS) depression model in mice was established, and then intraperitoneal fluoxetine injections (10 mg/kg) were administered for a duration of 4 weeks. The behavioral changes induced by CUMS were evaluated by the tail suspension test, open field test, sucrose preference test, and elevated plus maze test. Quantitative real-time PCR was used to detect expression levels of miR-124 and its three precursor genes in hippocampus of mice. Western blotting was used to detect the expressions of Ezh2 and autophagy proteins (P62, Atg3, Atg7, LC3-I, and LC3- II) in hippocampus of mice.

Results
Depression-like behaviors were successfully induced in CUMS models and reversed by SSRI treatments. The expression levels of miR-124 and its precursor gene (miR-124-3) were significantly increased in the hippocampus of CUMS mice, while the expression levels were significantly decreased after 4 weeks of fluoxetine treatment. The mRNA and protein expressions of Ezh2, a validated target of miR-124, were decreased in the hippocampus of CUMS mice, and the fluoxetine treatment could reverse the expressions. A correlation analysis suggested that miR-124 had a significant negative correlation with Ezh2 mRNA expression. The protein levels of LC3-II/I, P62, and Atg7, which were found to be regulated by Ezh2, were increased in the hippocampus of CUMS mice and decreased after fluoxetine treatment.

Conclusion
We speculated that autophagy was enhanced in the CUMS model of depression and might be mediated by miR-124 targeting Ezh2.
Evaluating the Impact of ACGME Resident Duty Hour Restrictions on Patient Outcomes for Bilateral Breast Reductions
Authors: Chi David , Chen Austin D. , Wu Winona W. , Chattha Anmol , Lee Bernard T. , Lin Samuel J. 
Published: February 2023

Background:
The Accreditation Council for Graduate Medical Education (ACGME) implemented duty-hour restrictions limiting residents to 80 hours per week in 2003 and further extended restrictions in 2011 to improve resident and patient well-being. Numerous studies have examined the effects of these restrictions on patient outcomes with inconclusive results. Few efforts have been made to examine the impact of this reform on the safety of common plastic surgery procedures. This study seeks to assess the influence of ACGME duty-hour restrictions on patient outcomes, using bilateral breast reduction mammoplasty as a marker for resident involvement and operative autonomy.

Methods:
Bilateral breast reductions performed in the 3 years before and after each reform were collected from the National Inpatient Sample database: pre-duty hours (2000–2002), duty hours (2006–2008), and extended duty hours (2012–2014). Multivariable logistic regression models were constructed to investigate the association between ACGME duty hour restrictions on medical and surgical complications.

Results:
Overall, 19,423 bilateral breast reductions were identified. Medical and surgical complication rates in these patients increased with each successive iteration of duty hour restrictions (P < 0.001). The 2003 duty-hour restriction independently associated with increased surgical (OR = 1.51, P < 0.001) and medical complications (OR = 1.85, P < 0.001). The 2011 extended duty-hour restriction was independently associated with increased surgical complications (OR = 1.39, P < 0.001).

Conclusions:
ACGME duty-hour restrictions do not seem associated with better patient outcomes for bilateral breast reduction although there are multiple factors involved. These considerations and consequences should be considered in decisions that affect resident quality of life, education, and patient safety.
Concomitant Bandage Contact Lens, Oral Nicergoline, and Topical Autologous Serum for Severe Neurotrophic Keratitis
Authors: Polania-Baron Eduardo J. , Graue-Hernandez Enrique O. , Ramirez-Miranda Arturo , Navas Alejandro 
Published: February 2023

Background:
To report the outcomes of using the combination of oral nicergoline, autologous serum, and contact lens to enhance corneal epithelization in neurotrophic keratitis and to discuss the clinical potential of this management.

Methods:
This was a prospective consecutive case series study of eight patients treated for neurotrophic keratitis at the “Conde de Valenciana” Institute of Ophthalmology. Oral nicergoline, autologous serum, and bandage contact lens were initiated at the same time, immediately after stage 3 diagnosis keratitis was confirmed clinically, and until corneal epithelialization was achieved or eminent corneal perforation was seen. In patients where diabetes was a cause, glycosylate hemoglobin was measured to asses metabolic control. Corneal esthesiometry and corrected distance visual acuity were assessed before and after treatment.

Results:
This study included eight eyes of eight patients (5 men [62.5%], average age 57±17.9 years). All patients completed at least 1 month of follow-up after nicergoline and contact lens suspension. Of the eight eyes, no one had positive culture growth and complete epithelial healing was achieved in all cases. Half of patients had diabetes and had a poor metabolic control. Corneal sensitivity improved in all eyes almost 2 centimeters in Cochet–Bonnet esthesiometry (P=0.01). In addition, final visual acuity gains were obtained (P=0.100).

Conclusions:
The combination of oral nicergoline, autologous serum, and bandage contact lens simultaneously could be an alternative in the management of stage 3 neurotrophic keratitis when conventional medical treatment has no improvement of corneal epithelization.
Uveitis and glaucoma: a look at present day surgical options
Authors: Seow Wei Hong , Lim Chris Hong Long , Lim Blanche Xiao Hong , Lim Dawn Ka-Ann 
Published: February 2023

Purpose of review
To review the various surgical options in the management of medically refractory glaucoma in uveitic eyes.

Recent findings
Uveitic glaucoma is particularly challenging to manage. We look at the evidence for various surgical options, or the lack of, in the surgical management of medically refractory glaucoma in uveitis.

Summary
Conventional glaucoma filtration surgeries such as trabeculectomy and glaucoma drainage implants were more commonly described first line surgical options in the therapy of medically refractory uveitic glaucoma. However, with the introduction of newer implants and options of minimally invasive glaucoma surgeries, the choice of first line surgeries may now be possibly expanded to include other options. More research is required to evaluate the efficacy of the newer surgical options in the management of glaucoma in uveitis patients.
Impact of Food Insecurity and Undernutrition on Frailty and Physical Functioning in Aging People With HIV in the United States
Authors: Horvat Davey Christine , Navis Brianna , Webel Allison R. , Jankowski Catherine , Oliveira Vitor H. F. , Khuu Vincent , Cook Paul F. , Erlandson Kristine M. 
Published: February 2023

Abstract
We conducted an observational cross-sectional study to explore whether food insecurity or undernutrition was associated with frailty or low physical functioning in aging persons with HIV (PWH). Forty-eight PWH aged 50 years and older were enrolled. Independent samples t-tests and chi-square tests were used to examine the relationship of food insecurity or undernutrition to frailty or physical function. Participants were 58.6 (±6.3) years old, 83% male, 77% White, 21% Hispanic. In total, 44% experienced food insecurity and 71% experienced undernutrition, whereas 23% were frail and 69% were prefrail. Food insecurity was associated with impaired total short physical performance battery score (p = .02), impaired balance (p = .02), slower chair rise time (p = .03), and weight loss within 12 months (p = .05). Undernutrition was related to female gender (p = .01), worse frailty (p = .04), and weaker grip strength (p = .03). In this sample of undernourished and frail PWH, strong relationships between undernutrition and frailty were observed.
Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia
Authors: Hang Shyann M.T. , Hegele Robert A. , Berberich Amanda J. 
Published: February 2023

Purpose of review
Not all patients with severe hypertriglyceridemia develop acute pancreatitis. We surveyed recent literature on inter-individual genetic variation in susceptibility to pancreatitis.

Recent findings
Genetic determinants of pancreatitis include: rare Mendelian disorders caused by highly penetrant pathogenic variants in genes involved in trypsinogen activation; uncommon susceptibility variants in genes involved in trypsinogen activation, protein misfolding as well as calcium metabolism and cystic fibrosis, that have variable penetrance and show a range of odds ratios for pancreatitis; and common polymorphisms in many of the same genes that have only a small effect on risk. The role of these genetic variants in modulating pancreatitis risk in hypertriglyceridemia is unclear. However, among genetic determinants of plasma triglycerides, those predisposing to more severe hypertriglyceridemia associated with chylomicronemia appear to have higher pancreatitis risk.

Summary
Currently, among patients with severe hypertriglyceridemia, the most consistent predictor of pancreatitis risk is the triglyceride level. Furthermore, pancreatitis risk appears to be modulated by a higher genetic burden of factors associated with greater magnitude of triglyceride elevation. The role of common and rare genetic determinants of pancreatitis itself in this metabolic context is unclear.