bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ageing and quenching through the ageing diagram: predictions from simulations and observational constraints
Authors: Corcho-Caballero Pablo , Ascasibar Yago , Sánchez Sebastián F , López-Sánchez Ángel R 
Published: January 2023

ABSTRACT
We study recent changes on the star-formation history (SFH) of galaxies by means of the ageing diagram (AD), tracing the fraction of stars formed during the last ∼20 Myr through the equivalent width of the $\rm H\alpha$ line and ∼1−3 Gyr through the dust-corrected optical colour (g − r)0or the Balmer break. We provide a physical characterization by using Pipe3Destimates of the SFH of Calar Alto Legacy Integral Field Area and Mapping Nearby Galaxies at Apache Point Observatory galaxies, in combination with the predictions from IllustrisTNG-100. Our results show that the AD may be divided into four domains that correlate with the stellar mass fractions formed in the last 20 Myr and 3 Gyr: ageing systems, whose star formation rate changes on scales of several Gyr, account for $70-80{{\ \rm per\ cent}}$ of the galaxy population. Objects whose SFH was abruptly truncated in the last ∼1 Gyr arrange along a detached quenched sequence that represents $\sim 5-10{{\ \rm per\ cent}}$ by (volume-corrected) number for 109 &lt; M*/M⊙ &lt; 1012. Undetermined systems represent an intermediate population between the ageing and quenched regimes. Finally, Retired galaxies, dominated by old stellar populations, are located at the region in the AD where the ageing and quenched sequences converge. Defining different star formation activity levels in terms of the birth rate parameter $b\equiv \frac{SFR}{\langle SFR \rangle }$, we find that galaxies transit from the ageing to quenched sequences on scales ∼500 Myr. We conclude that the AD provides a useful tool to discern recently quenched galaxies from the dominant ageing population.
Physiological effects of yerba maté (Ilex paraguariensis): a systematic review
Authors: José Manuela F B , Machado Roberta P , Araujo Pablo A B , Speretta Guilherme F 
Published: January 2023

Abstract

Context
Clinical studies have found an association between yerba maté intake and beneficial physiological effects. Nevertheless, no systematic reviews have been conducted to shed light on the data supporting this association.

Objective
The present systematic review aimed to investigate the physiological effects of yerba maté.

Data Sources
Searches were performed in 6 databases (Embase, LILACS, Scopus, PubMed, SciELO, Web of Science) and 3 grey literature databases (OpenGrey, ProQuest, Google Scholar). Relevant publications were identified, and the reference lists of included studies were searched manually for randomized clinical trials, nonrandomized clinical trials, and observational studies investigating the physiological effects of yerba maté.

Data Extraction
Risk of bias was assessed using the Cochrane risk of bias tool for randomized trials and the Cochrane ROBINS-I (Risk Of Bias In Nonrandomized Studies of Interventions) tool. Joanna Briggs Institute critical appraisal tools were used for cross-sectional, case series, cohort, and case-control studies. The overall certainty of the evidence was estimated using the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) working group summary of findings table.

Data Analysis
Of 1096 studies identified, 32 were included. Studies showed consistent effects of yerba maté intake on metabolism improvement and antioxidant and anti-inflammatory activities in different populations. Benefits for body weight and composition, exercise performance, mood, and appetite, in addition cardio- and neuroprotective effects, were also observed. Risk of bias was categorized as high in 22 studies, moderate in 9 studies, and low in 1 study. The certainty of evidence ranged from moderate to very low.

Conclusion
The available literature indicates that yerba maté can be used within a balanced and healthy diet for prevention and adjuvant treatment of chronic diseases.

Systematic Review Registration
PROSPERO registration number CRD42020200196.
Countering the Fiction of Neutrality: Pushing for Transparency?
Authors: Van de Graaf Cathérine , Nußberger Angelika 
Published: January 2023

Abstract
Many scholars accept that the principle of neutrality is to a large extent a fictional concept. They often propose different variations that would better realize its prescribed aim of equality. In this contribution, we argue that state agents in general, and judges in particular, cannot be ‘neutral’ as they are not abstract entities. They do not enter the judiciary with a clean slate but as persons subjected to a myriad of formative experiences, connected to their worldview, gender, nationality, socio-economic background, and so on. Thus, the fiction of neutrality of the State is inevitably linked with a lack of transparency: not showing religious, atheist, or agnostic as well as political convictions is not the same as not having them. An alternative model would be to emphasize transparency, but simultaneously strive for diversity of different convictions represented on the Bench. Such a system would prompt self-conscious reflection on the role of worldviews in the judging process. It would, however, create new dilemmas as it would be impossible to reach an adequate equilibrium and thus undermine the confidence in the judiciary.
Clinical Treatment Guidelines for Tafasitamab plus Lenalidomide in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Authors: Nedved Adrienne , Maddocks Kami , Nowakowski Grzegorz S 
Published: January 2023

AbstractDiffuse large B-cell lymphoma (DLBCL) accounts for approximately 24% of new cases of B-cell non-Hodgkin lymphoma in the US each year. Up to 50% of patients relapse or are refractory (R/R) to the standard first-line treatment option, R-CHOP. The anti-CD19 monoclonal antibody tafasitamab, in combination with lenalidomide (LEN), is an NCCN preferred regimen for transplant-ineligible patients with R/R DLBCL and received accelerated approval in the US (July 2020) and conditional marketing authorization in Europe (August 2021) and other countries, based on data from the L-MIND study. The recommended dose of tafasitamab is 12 mg/kg by intravenous infusion, administered in combination with LEN 25 mg for 12 cycles, followed by tafasitamab monotherapy until disease progression or unacceptable toxicity. Tafasitamab + LEN is associated with durable responses in patients with R/R DLBCL. The majority of clinically significant treatment-associated adverse events are attributable to LEN and can be managed with dose modification and supportive therapy. We provide guidelines for the management of patients with R/R DLBCL treated with tafasitamab and LEN in routine clinical practice, including elderly patients and those with renal and hepatic impairment, and advice regarding patient education as part of a comprehensive patient engagement plan. Our recommendations include LEN administration at a reduced dose if required in patients unable to tolerate the recommended dose. No dose modification is required for tafasitamab in special patient populations.
Church
Authors: Day Abby 
Published: January 2023

Abstract
This chapter reviews one of the most common explanations the Boomers gave about their earlier church-going pattern: ‘It was a social thing’. In their childhoods the church was a social community to which their families belonged, both for social contact and to meet society’s wider expectations about an important mode of ‘respectability’. Boomers did not generally experience religious practices in their homes or have a sense of being close to God or Jesus during their childhood years: the church was a place to meet friends and family, not commune with anything more ‘spiritual’. The common, mid-twentieth-century practice of segregating children and adults through a Sunday School appears to have had the unintended consequence of diminishing any sense of religiosity or spirituality.
Creating a Seamless Organization
Authors: Kanore Lalit , Masatkar Priti 
Published: January 2023

Abstract
The case study is a typical representative of majority of the family managed large groups of industries engaged in manufacturing marketing and trading activity through several of their group companies. The case represents major issues faced by the generational and successional chiefs as heirs to the traditional businesses of group companies in their major tasks of further steering of the group companies through the turn around and transformational changes compelled by the major disruptions due to technology, trade restrictions in international businesses, and compliance to several regulatory norms towards climate change and pollution control along with sustainability standards. It is a real churn that these new generational chiefs have to manage to sustain and grow their businesses.
Sony Pictures Network— A New PMA Philosophy
Authors: Praveen Roopa , Aher Dilip , Anute Nilesh 
Published: January 2023

Abstract
Sony Pictures Networks India (SPN has several channels including Sony Entertainment Television SET and SET HD), one of India’s leading Hindi general entertainment television channels. SPN reaches out to over 700 million viewers in India and is available in 167 countries. The PESTEL/PESTLE analysis of Sony Corporation reveals a number of significant opportunities and threats that shape the electronics, gaming, entertainment, and financial services markets. As part of its talent development program schedules, SPN are also upskilling their current employees by providing alternate learning experiences, reverse mentoring, expert talks, and design thinking workshops, among other initiatives. The HR policies at Sony is employee inclusive, however due to the growing workforce there have been certain management changes that Sony has had to incorporate. This case delves into the management style of Sony for its employees and analyses the best practices.
Employee Unrest and the Role of Labour Unions
Authors: Parab Varsha , Mahadik Ramesh , Tripathi Diksha 
Published: January 2023

Abstract
In 1970s when industrial revolution was at its boom in India, four engineers started manufacturing of Stainless steel and Mild steel for pharmaceutical, chemical, fertilisers, and many other companies. The chaos started in 1978 due to financial crisis in the organization, the two labour unions and their demands is the central character of the case. The case throws light on how due to leadership issues, the management of the company always takes the benefit of different leaders by keeping a different relationship with two different leaders. Almost two decades due to disputes between two union companies could not give principal benefits to the employee as they demanded at the beginning of the company’s establishment. The case discusses on various laws provided to safeguard employee benefits by the state. It narrates the benefit and struggle of employees in SME’s.
Do not panic: An intron-centric guide to alternative splicing
Authors: Petrillo Ezequiel 
Published: January 2023

Abstract
This review is an attempt to establish concepts of splicing and alternative splicing giving proper relevance to introns, the key actors in this mechanism. It might also work as a guide for those who found their favorite gene undergoes alternative splicing and could benefit from gaining a theoretical framework to understand the possible impacts of this process. This is not a thorough review of all the work in the field, but rather a critical review of some of the most relevant work done to understand the underlying mechanisms of splicing and the key questions that remain unanswered such as: What is the physiological relevance of alternative splicing? What are the functions of the different outcomes? To what extent do different alternative splicing types contribute to the proteome? Intron retention is the most frequent alternative splicing event in plants and, although scientifically neglected, it is also common in animals. This is a heterogeneous type of alternative splicing that includes different sub-types with features that have distinctive consequences in the resulting transcripts. Remarkably, intron retention can be a dead end for a transcript, but it could also be a stable intermediate whose processing is resumed upon a particular signal or change in the cell status. New sequencing technologies combined with the study of intron lariats in different conditions might help to answer key questions and could help us to understand the actual relevance of introns in gene expression regulation.
One-helix protein 2 is not required for the synthesis of photosystem II subunit D1 in Chlamydomonas
Authors: Wang Fei , Dischinger Korbinian , Westrich Lisa Désirée , Meindl Irene , Egidi Felix , Trösch Raphael , Sommer Frederik , Johnson Xenie , Schroda Michael , Nickelsen Joerg , Willmund Felix , Vallon Olivier , Bohne Alexandra-Viola 
Published: January 2023

AbstractIn land plants and cyanobacteria, co-translational association of chlorophyll (Chl) to the nascent D1 polypeptide, a reaction center protein of photosystem II (PSII), requires a Chl binding complex consisting of a short-chain dehydrogenase (high chlorophyll fluorescence 244 [HCF244]/uncharacterized protein 39 [Ycf39]) and one-helix proteins (OHP1 and OHP2 in chloroplasts) of the light-harvesting antenna complex superfamily. Here, we show that an ohp2 mutant of the green alga Chlamydomonas (Chlamydomonas reinhardtii) fails to accumulate core PSII subunits, in particular D1 (encoded by the psbA mRNA). Extragenic suppressors arose at high frequency, suggesting the existence of another route for Chl association to PSII. The ohp2 mutant was complemented by the Arabidopsis (Arabidopsis thaliana) ortholog. In contrast to land plants, where psbA translation is prevented in the absence of OHP2, ribosome profiling experiments showed that the Chlamydomonas mutant translates the psbA transcript over its full length. Pulse labeling suggested that D1 is degraded during or immediately after translation. The translation of other PSII subunits was affected by assembly-controlled translational regulation. Proteomics showed that HCF244, a translation factor which associates with and is stabilized by OHP2 in land plants, still partly accumulates in the Chlamydomonas ohp2 mutant, explaining the persistence of psbA translation. Several Chl biosynthesis enzymes overaccumulate in the mutant membranes. Partial inactivation of a D1-degrading protease restored a low level of PSII activity in an ohp2 background, but not photoautotrophy. Taken together, our data suggest that OHP2 is not required for psbA translation in Chlamydomonas, but is necessary for D1 stabilization.
Determination and characterization of patient subgroups based on pain trajectories in hand osteoarthritis
Authors: van der Meulen Coen , van de Stadt Lotte A , Rosendaal Frits R , Runhaar Jos , Kloppenburg Margreet 
Published: January 2023

Abstract

Objectives
To investigate pain, pain trajectories and their determinants in hand osteoarthritis (OA).

Methods
Data from the HOSTAS (Hand OSTeoArthritis in Secondary care) consisting of consecutive hand OA patients were used. Australian Canadian Osteoarthritis Hand Index (AUSCAN) pain was measured yearly for four years. Patients with complete AUSCAN at ≥2 time points were eligible for longitudinal analysis. Associations between variables of interest and baseline AUSCAN pain were investigated with linear regression. Development of pain over time was modelled using latent class growth analysis (LCGA). Associations of LCGA classes with variables of interest were analysed using multinomial logistic regression adjusted for baseline pain.

Results
A total of 484/538 patients [mean (s.d.) age 60.8 (8.5) years, 86% women, mean (s.d.) AUSCAN pain 9.3 (4.3)] were eligible for longitudinal analysis. Sex, marital and working status, education, disease duration and severity, anxiety and depression scores, lower health-related quality of life (HR-QoL), specific illness perceptions and coping styles were associated with baseline pain. LCGA yielded three classes, characterized by average pain levels at baseline; average pain remained stable over time within classes. Classes with more pain were positively associated with BMI, tender joint count, symptom duration, hand function scores and depression scores, negatively with physical HR-QoL, and education level.

Conclusion
Baseline pain was associated with patient and disease characteristics, and psychosocial factors. LCGA showed three pain trajectories in hand OA patients, with different baseline pain levels and stable pain over time. Classes were distinguished by BMI, education level, disease severity, depression and HR-QoL.
Rehabilitative Training Enhances Therapeutic Effect of Human iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury
Authors: Shibata Takahiro , Tashiro Syoichi , Shibata Shinsuke , Shinozaki Munehisa , Shindo Tomoko , Hashimoto Shogo , Kawai Momotaro , Kitagawa Takahiro , Ago Kentaro , Matsumoto Morio , Nakamura Masaya , Okano Hideyuki , Nagoshi Narihito 
Published: January 2023

AbstractCell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) is a new therapeutic strategy for spinal cord injury (SCI). Preclinical studies have demonstrated the efficacy of hiPSC-NS/PCs transplantation in the subacute phase of SCI. However, locomotor recovery secondary to hiPSC-NS/PCs transplantation is limited in the chronic phase, suggesting that additional treatment, including rehabilitative training, is required to ensure recovery. The therapeutic potential of hiPSC-NS/PCs that qualify for clinical application is yet to be fully delineated. Therefore, in this study, we investigated the therapeutic effect of the combined therapy of clinical-grade hiPSC-NS/PCs transplantation and rehabilitative training that could produce synergistic effects in a rodent model of chronic SCI. Our findings indicated that rehabilitative training promoted the survival rate and neuronal differentiation of transplanted hiPSC-NS/PCs. The combination therapy was able to enhance the expressions of the BDNF and NT-3 proteins in the spinal cord tissue. Moreover, rehabilitation promoted neuronal activity and increased 5-HT-positive fibers at the lumbar enlargement. Consequently, the combination therapy significantly improved motor functions. The findings of this study suggest that the combined therapy of hiPSC-NS/PCs transplantation and rehabilitative training has the potential to promote functional recovery even when initiated during chronic SCI.
Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells
Authors: Godoy-Parejo Carlos , Deng Chunhao , Xu Jiaqi , Zhang Zhaoying , Ren Zhili , Ai Nana , Liu Weiwei , Ge Wei , Deng Chuxia , Xu Xiaoling , Chin Y Eugene , Chen Guokai 
Published: January 2023

Abstract
The interplay among mitogenic signaling pathways is crucial for proper embryogenesis. These pathways collaboratively act through intracellular master regulators to determine specific cell fates. Identifying the master regulators is critical to understanding embryogenesis and to developing new applications of pluripotent stem cells. In this report, we demonstrate protein kinase C (PKC) as an intrinsic master switch between embryonic and extraembryonic cell fates in the differentiation of human pluripotent stem cells (hPSCs). PKCs are essential to induce the extraembryonic lineage downstream of BMP4 and other mitogenic modulators. PKC-alpha (PKCα) suppresses BMP4-induced mesoderm differentiation, and PKC-delta (PKCδ) is required for trophoblast cell fate. PKC activation overrides mesoderm induction conditions and leads to extraembryonic fate. In contrast, PKC inhibition leads to β-catenin (CTNNB1) activation, switching cell fate from trophoblast to mesoderm lineages. This study establishes PKC as a signaling boundary directing the segregation of extraembryonic and embryonic lineages. The manipulation of intrinsic PKC activity could greatly enhance cell differentiation under mitogenic regulation in stem cell applications.
Histopathologic features and parameters predicting recurrence potential of small renal masses
Authors: Bajramović Senad , Hasanović Berina , Alić Jasmin , Šabanović Bajramović Nirvana , Aganović Damir 
Published: January 2023

Abstract

Background
Small renal masses (SRMs) are defined as contrast-enhanced masses with a diameter of ≤4 cm, usually consistent with clinical stage T1a renal cell carcinoma (RCC). This study aimed to explore the histopathological features of a contemporary series of SRMs and investigate parameters that could predict their pathological nature, metastatic potential, and recurrence potential.

Materials and methods
Small renal masses were identified in 166 of 427 patients who underwent surgery for suspected RCC. The radical nephrectomy/partial nephrectomy ratio was 1:44, and autotransplantation was performed in a single case. Variables associated with metastatic recurrence of SRM were analyzed using χ2 and logistic regression models.

Results
Renal cell carcinoma was confirmed in 86% (n = 143) of cases, whereas benign tumors were present in 14% (n = 23) of cases. Seventeen percent of the RCC cases were high-grade (Fuhrman G3–4). Among SRMs with a diameter of >2 cm, 71% were malignant. The mean ± standard deviation diameter of the removed SRMs was 28 ± 12 mm, significantly higher in the malignant SRMs group (31 ± 8 vs. 24 ± 9 mm) (p = 0.005). During follow-up, local recurrence was identified in 4 patients versus new distant metastasis in 11 patients. Metastatic lesions were detected in the lungs (1.8%), bone (1.2%), distant (1.9%) and regional lymph nodes (1.2%), liver (0.6%), and multiple organs (2.4%). Patients with malignant SRMs were significantly older than those with benign tumors (p = 0.036). The multivariate analysis identified tumor size, Fuhrman grade, stage, nodal and distant metastasis status, tumor localization, and treatment modality as characteristics significant for tumor recurrence.

Conclusions
The majority of treated neoplasms were malignant, but their incidence was low among SRMs with a diameter of <2 cm. Our results emphasized the importance of histopathological features and treatment modalities in predicting malignant recurrence.