bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influences of Physical Parameters of a Solar Concentrator Cooker
Authors: Gbembongo Thierry Serge , Mackpayen Auguste , Lengaye Saint-Cyr , Pakouzou Bienvenu 
Published: January 2023

This work focuses on the modelling and simulation of a solar concentrator cooker. The equations governing the heat transfers of the solar cooker are discretised by an implicit finite difference method and solved via the Gaussian algorithm, coupled with an iterative procedure.
The FORTRAN numerical code that simulates the operation of the solar cooker, using meteorological data from the city of Bangui, was developed. In this simulation, the influence of physical parameters as well as of the different components of the cooker is analysed, notably: the nature of the materials used, the dimensions of the cooker. The results show that a solar flux of 900W/m² allows the determination of the different optimal parameters of the cooker.
The dimensions of the parallelepipedic cooker [60 cm*50 cm*50 cm], made it possible to obtain a thermal efficiency varying from 42% to 45%. The influence of these physical parameters shows that copper is a good conductor and the thermal conductivity is higher the thinner the wall thickness (3 mm) of the pot.
Disorder of consciousness: Structural integrity of brain networks for the clinical assessment
Authors: Medina Carrion Jean Paul , Stanziano Mario , D'Incerti Ludovico , Sattin Davide , Palermo Sara , Ferraro Stefania , Sebastiano Davide Rossi , Leonardi Matilde , Bruzzone Maria Grazia , Rosazza Cristina , Nigri Anna 
Published: January 2023

AbstractAimWhen studying brain networks in patients with Disorders of Consciousness (DoC), it is important to evaluate the structural integrity of networks in addition to their functional activity. Here, we investigated whether structural MRI, together with clinical variables, can be useful for diagnostic purposes and whether a quantitative analysis is feasible in a group of chronic DoC patients.MethodsWe studied 109 chronic patients with DoC and emerged from DoC with structural MRI: 65 in vegetative state/unresponsive wakefulness state (VS/UWS), 34 in minimally conscious state (MCS), and 10 with severe disability. MRI data were analyzed through qualitative and quantitative approaches.ResultsThe qualitative MRI analysis outperformed the quantitative one, which resulted to be hardly feasible in chronic DoC patients. The results of the qualitative approach showed that the structural integrity of HighOrder networks, altogether, had better diagnostic accuracy than LowOrder networks, particularly when the model included clinical variables (AUC = 0.83). Diagnostic differences between VS/UWS and MCS were stronger in anoxic etiology than vascular and traumatic etiology. MRI data of all LowOrder and HighOrder networks correlated with the clinical score. The integrity of the left hemisphere was associated with a better clinical status.ConclusionsStructural integrity of brain networks is sensitive to clinical severity. When patients are chronic, the qualitative analysis of MRI data is indicated.
Precision Tuning of Highly Selective Polyelectrolyte Membranes for Redox‐Mediated Electrochemical Separation of Organic Acids
Authors: Kim Nayeong , Lee Jiho , Su Xiao 
Published: January 2023

AbstractThe design of molecularly selective membranes is of paramount importance in the electrochemical separation of organic acids from complex fermentation streams, due to the presence of multicomponent species. However, current membrane‐integrated electrochemical technologies have relied on ion‐exchange membranes that lack intrinsic ion‐selectivity, thus preventing their application for value‐added recovery of organic acids from competing ions. Here, this study demonstrates a layer‐by‐layer polyelectrolyte functionalization approach for controlling ion‐selectivity, to achieve the multicomponent separation of organic acids in a redox‐flow electrodialysis platform. This study carries out a detailed investigation of the surface morphology and physicochemical properties of functionalized membranes, underlying that the selectivity of organic acids can be precisely tuned through the control of the hydrophilicity, electrostatic repulsion, and steric hindrance. Tailoring of membrane physiochemical properties enables up to complete retention of succinate, while enhancing the total flux. This organic acid retention is extended to the control over mono‐ and multivalent organic acids. Integration of functionalized membrane with the redox‐flow system allows selective succinic acid recovery with 99.7% purity from a synthetic fermentation mixture, high energy efficiency, and membrane stability. Modulation of ion‐selectivity through membrane functionalization coupled with electrochemical architecture design enables a sustainable pathway for multicomponent separations in biomanufacturing.
Metal‐Organic Frameworks for Gene Therapy and Detection
Authors: He Yaping , Li Daifeng , Wu Li , Yin Xianzhen , Zhang Xiaojian , Patterson Laurence H. , Zhang Jiwen 
Published: January 2023

AbstractGene therapy holds great promise as a biomedicine for treating cancer, viral infection, and recessive gene disorders, while genetic detection has been used for disease diagnosis and prevention. The appropriate carrier is crucial to improve the delivery efficiency of nucleic acids. Although viral and nonviral delivery vectors have been developed, their poor nucleic acid loading efficiency, off‐target toxicity, and immunogenicity significantly hamper their use. Metal‐organic frameworks (MOFs) have attracted a lot of attention owing to their high surface areas and tunable structures. Recently, nanometric MOFs are shown to be promising nonviral vectors in gene delivery and detection although at an early stage of development. This review focuses on highlighting the current status and promising breakthroughs of MOF use in nucleic acid delivery, including siRNA, miRNA and mRNA delivery, DNA gene delivery and transfection, as well as probes for detection of gene expression. This study will help promote the clinical transformation and application of gene modulation, gene delivery, and detection that use of MOFs can offer.
Construction of VS2/VOx Heterostructure via Hydrolysis‐Oxidation Coupling Reaction with Superior Sodium Storage Properties
Authors: Zhang Yuxiang , Chen Yangziyu , Jiang Yan , Wang Jing , Zheng Xiangyi , Han Bo , Xia Kaisheng , Gao Qiang , Cai Zhao , Zhou Chenggang , Sun Ruimin 
Published: January 2023

AbstractHeterostructure engineering is one of the most promising modification strategies for reinforcing Na+ storage of transition metal sulfides. Herein, based on the spontaneous hydrolysis‐oxidation coupling reaction of transition metal sulfides in aqueous media, a VOx layer is induced and formed on the surface of VS2, realizing tight combination of VS2 and VOx at the nanoscale and constructing homologous VS2/VOx heterostructure. Benefiting from the built‐in electric field at the heterointerfaces, high chemical stability of VOx, and high electrical conductivity of VS2, the obtained VS2/VOx electrode exhibits superior cycling stability and rate properties. In particular, the VS2/VOx anode shows a high capacity of 878.2 mAh g−1 after 200 cycles at 0.2 A g−1. It also exhibits long cycling life (721.6 mAh g−1 capacity retained after 1000 cycles at 2 A g−1) and ultrahigh rate property (up to 654.8 mAh g−1 at 10 A g−1). Density functional theory calculations show that the formation of heterostructures reduces the activation energy for Na+ migration and increases the electrical conductivity of the material, which accelerates the ion/electron transfer and improves the reaction kinetics of the VS2/VOx electrode.
Transcriptomic Changes toward Osteogenic Differentiation of Mesenchymal Stem Cells on 3D‐Printed GelMA/CNC Hydrogel under Pulsatile Pressure Environment
Authors: Ganguly Keya , Dutta Sayan Deb , Randhawa Aayushi , Patel Dinesh K. , Patil Tejal V. , Lim Ki‐Taek 
Published: January 2023

AbstractBiomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory outcomes. Here, it is investigated how human bone‐marrow‐derived mesenchymal stem cells (hBMSCs) differentiated into early osteoblasts on remarkably soft 3D hydrogel (70 ± 0.00049 Pa). Specifically, hBMSCs seeded onto cellulose nanocrystals incorporated methacrylate gelatin hydrogels are subjected to pulsatile pressure stimulation (PPS) of 5–20 kPa for 7 days. The PPS stimulates cellular processes such as mechanotransduction, cytoskeletal distribution, prohibition of oxidative stress, calcium homeostasis, osteogenic marker gene expression, and osteo‐specific cytokine secretions in hBMSCs on soft substrates. The involvement of Piezo 1 is the main ion channel involved in mechanotransduction. Additionally, RNA‐sequencing results reveal differential gene expression concerning osteogenic differentiation, bone mineralization, ion channel activity, and focal adhesion. These findings suggest a practical and highly scalable method for promoting stem cell commitment to osteogenesis on soft matrices for clinical reconstruction.
Advanced Material Design and Engineering for Water‐Based Evaporative Cooling
Authors: Li Renyuan , Wang Wenbin , Shi Yifeng , Wang Chang‐ting , Wang Peng 
Published: January 2023

AbstractWater‐based evaporative cooling is emerging as a promising technology to provide sustainable and low‐cost cold to alleviate the rising global cooling demand. Given the significant and fast progress made in recent years, this review aims to provide a timely overview on the state‐of‐the‐art material design and engineering in water‐based evaporative cooling. The fundamental mechanisms and major components of three water‐based evaporative cooling processes are introduced, including direct evaporative cooling, cyclic sorption‐driven liquid water evaporative cooling (CSD‐LWEC), and atmospheric water harvesting‐based evaporative cooling (AWH‐EC). The distinctive requirements on the sorbent materials in CSD‐LWEC and AWH‐EC are highlighted, which helps synthesize the literature information on the advanced material design and engineering for the purpose of improving cooling performance. The challenges and future outlooks on further improving the water‐based evaporative cooling performance are also provided.
Orally Administrable H2S‐Scavenging Metal–Organic Framework Prepared by Co‐Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu
Authors: Dou Yunsheng , Liu Ping , Ding Ziqiao , Zhou Yue , Jing Huaqing , Ren Yingzi , Heger Zbynek , Adam Vojtech , Li Nan 
Published: January 2023

AbstractIntestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption, and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by the sulfate‐reducing bacteria metabolism contributes to development of IBDs via epithelial barrier breakdown. Conventional interventions, such as surgery and anti‐inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)‐based polymer‐coated Zr‐based metal–organic framework (UiO‐66) with a Cux‐rhodamine B (CR) probe (hereinafter referred to as HUR), is produced via a co‐flow microfluidic approach with the ability to reduce H2S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO‐66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration, and TJ proteins upregulation via H2S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR is verified to be a promising theranostic platform able to decrease the H2S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.
A New Zinc Salt Chemistry for Aqueous Zinc‐Metal Batteries
Authors: Du Haoran , Dong Yanhao , Li Qing‐Jie , Zhao Ruirui , Qi Xiaoqun , Kan Wang‐Hay , Suo Liumin , Qie Long , Li Ju , Huang Yunhui 
Published: January 2023

AbstractAqueous zinc‐ion batteries (ZIBs) are promising energy storage solutions with low cost and superior safety, but they suffer from chemical and electrochemical degradations closely related to the electrolyte. Here, a new zinc salt design and a drop‐in solution for long cycle‐life aqueous ZIBs are reported. The salt Zn(BBI)2 with a rationally designed anion group, N‐(benzenesulfonyl)benzenesulfonamide (BBI−), has a special amphiphilic molecular structure, which combines the benefits of hydrophilic and hydrophobic groups to properly tune the solubility and interfacial condition. This new zinc salt does not contain fluorine and is synthesized via a high‐yield and low‐cost method. It is shown that 1 m Zn(BBI)2 aqueous electrolyte with a widened cathodic stability window effectively stabilizes Zn metal/H2O interface, mitigates chemical and electrochemical degradations, and enables both symmetric and full cells using a zinc‐metal electrode.
Control of Host‐Matrix Morphology Enables Efficient Deep‐Blue Organic Light‐Emitting Devices
Authors: Zhao Haonan , Kim Jongchan , Ding Kan , Jung Mina , Li Yongxi , Ade Harald , Lee Jun Yeob , Forrest Stephen R. 
Published: January 2023

AbstractMixing a sterically bulky, electron‐transporting host material into a conventional single host–guest emissive layer is demonstrated to suppress phase separation of the host matrix while increasing the efficiency and operational lifetime of deep‐blue phosphorescent organic light‐emitting diodes (PHOLEDs) with chromaticity coordinates of (0.14, 0.15). The bulky host enables homogenous mixing of the molecules comprising the emissive layer while suppressing single host aggregation; a significant loss channel of nonradiative recombination. By controlling the amorphous phase of the host‐matrix morphology, the mixed‐host device achieves a significant reduction in nonradiative exciton decay, resulting in 120 ± 6% increase in external quantum efficiency relative to an analogous, single‐host device. In contrast to single host PHOLEDs where electrons are transported by the host and holes by the dopants, both charge carriers are conducted by the mixed host, reducing the probability of exciton annihilation, thereby doubling of the deep‐blue PHOLED operational lifetime. These findings demonstrate that the host matrix morphology affects almost every aspect of PHOLED performance.
Tunable NIR Lasing in MOF for Multi‐Level Complex Photonic Barcodes
Authors: Zhang Lin , Li Hongjun , Yang Yu , Cui Yuanjing , Qian Guodong 
Published: January 2023

AbstractDeveloping functional photonic tags is of great importance to meet the globally increasing demand for information security and anti‐counterfeiting. However, it still suffers from the restricted encoding capacity, low complexity, and unsatisfactory confidentiality. Herein, a strategy is demonstrated to construct multi‐level complex photonic barcodes in near‐infrared (NIR) region based on a composition‐graded metal‐organic framework (MOF) heterostructure with the hierarchical encapsulation of different dye molecules. Such MOF microstructure exhibits switchable dual‐wavelength NIR lasing by adjusting the excited position, polarization direction, and pump energy. Thus, through converting the laser spectra with dynamic and regular changes to solid bars, the multi‐block photonic barcodes with three‐level encoding system are constructed, dramatically increasing the complexity and capacity. It makes the MOF‐based heterostructure with switchable lasing properties become a hard‐to‐counterfeit potential material for advanced anticounterfeiting of high‐level security.
LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53‐Defective Cancer Cells
Authors: La Ting , Chen Song , Zhao Xiao Hong , Zhou Shuai , Xu Ran , Teng Liu , Zhang Yuan Yuan , Ye Kaihong , Xu Liang , Guo Tao , Jamaluddin Muhammad Fairuz , Feng Yu Chen , Tang Hai Jie , Wang Yanliang , Xu Qin , Gu Yue , Cao Huixia , Liu Tao , Thorne Rick F. , Shao Feng‐Min , Zhang Xu Dong , Jin Lei 
Published: January 2023

AbstractP53 inactivation occurs in about 50% of human cancers, where p53‐driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, this work shows that the E2F1‐responsive lncRNA LIMp27 selectively represses p27 expression and contributes to proliferation, tumorigenicity, and treatment resistance in p53‐defective colon adenocarcinoma (COAD) cells. LIMp27 competes with p27 mRNA for binding to cytoplasmically localized hnRNA0, which otherwise stabilizes p27 mRNA leading to cell cycle arrest at the G0/G1 phase. In response to DNA damage, LIMp27 is upregulated in both wild‐type and p53‐mutant COAD cells, whereas cytoplasmic hnRNPA0 is only increased in p53‐mutant COAD cells due to translocation from the nucleus. Moreover, high LIMp27 expression is associated with poor survival of p53‐mutant but not wild‐type p53 COAD patients. These results uncover an lncRNA mechanism that promotes p53‐defective cancer pathogenesis and suggest that LIMp27 may constitute a target for the treatment of such cancers.
A Flexible Wireless sEMG System for Wearable Muscle Strength and Fatigue Monitoring in Real Time
Authors: Gong Qibei , Jiang Xijun , Liu Yuxuan , Yu Min , Hu Youfan 
Published: January 2023

AbstractThe detection of surface electromyography (sEMG) signals on the skin has attracted increasing attention because of its ability to monitor muscle conditions in a noninvasive manner and thus possesses great application potential to assess athletic status and training efficiency in real time or to evaluate postoperative muscle rehabilitation conveniently. Here, a flexible wireless sEMG monitoring system that consists of a stretchable sEMG epidermal patch and a flexible printed circuit board to provide real‐time evaluation of muscle strength and fatigue is reported. The epidermal patch is designed to have good stretchability and permeability and optimized to ensure a low contact impedance with the skin and minimized background noise for sEMG signal acquisition with high fidelity. Six commonly used time‐domain and two frequency‐domain features extracted from sEMG signals are systematically analyzed, and a strategy for feature selection and pattern identification is proposed that eventually enables the real‐time assessment of muscle strength and fatigue by using an integrated system in a wearable form.
When cointegration is interrupted: Price transmission analysis in the Italian dairy‐feed industry
Authors: Cattivelli Luca , Antonioli Federico 
Published: January 2023

AbstractWe analyze price transmission dynamics in the under‐investigated feed supply chain, applying a special case of the Threshold Vector Error Correction model where the cointegrating relationship is interrupted. Weekly Italian dairy feed and corn prices are used, finding evidence of asymmetric price transmission when the feed industry's margins are squeezed and highly volatile. The proposed Interrupted Threshold Cointegration model represents a valid complement to existing threshold and regime‐switching techniques, allowing for the application of an agile nonstructural error correction model when standard cointegration tests fail to detect any long‐run relationship between price series. [EconLit Citations: Q11, Q13, C24].
Burned and buried: A vibrational spectroscopy analysis of burial‐related diagenetic changes of heat‐altered human bones
Authors: Rosa Joana , Vassalo Ana R. , Amarante Ana , Batista de Carvalho Luis A. E. , Marques Maria Paula M. , Ferreira Maria Teresa , Gonçalves David 
Published: January 2023

AbstractObjectivesThe analysis of burned human remains can be very challenging due to heat‐induced alterations. Occasionally, human bones present these coupled with diagenetic changes, offering even more of a challenge, since there is a lack of studies regarding interactions between both taphonomic phenomena. With this study, we aimed to assess and document the effects of inhumation on the chemical composition of both unburned and burned human skeletal remains.Materials and MethodsWe buried, for 5 years, four groups of human bone samples comprising unburned bones and bones experimentally burned at 500, 900, and 1050 °C. Periodic exhumations were carried out to collect bone samples to be analyzed through Fourier transform infrared spectroscopy in attenuated total reflectance mode, in order to calculate four chemical indexes: (1) crystallinity index (CI); (2) type B carbonates to phosphate index (BPI); (3) total carbonates (A + B) to carbonate B ratio (C/C); and (4) OH to phosphate ratio (OH/P).ResultsAfter inhumation, CI and C/C of unburned bones and bones burned at 500 °C, and BPI of bones burned at 1050 °C did not vary significantly. However, the remaining indexes showed both relevant increments and reductions throughout observations, depending on burning temperature and index.DiscussionOur results suggest that diagenesis can have an effect in bone's molecular composition. However, these effects do not seem to significantly affect the conclusions that can be taken from the analysis of infrared bone spectra, at least in the case of inhumations with a duration of 5 years or less.
The ambivalence toward neuropsychology in dementia research, diagnosis, and drug development: Myths and misconceptions
Authors: Jónsdóttir María K. , Harrison John , Hannesdóttir Kristín I. 
Published: January 2023

AbstractClinical assessment remains the gold standard for diagnosing dementia, monitoring progression, and conducting clinical research. Biomarkers hold promise for targeted therapeutic approaches, selection of participants in clinical trials, and direct physiological efficacy readouts. However, the anchoring of biomarker research to clinical symptomatology is often based on short and insensitive cognitive screening. This gives the impression that cognitive symptoms occur relatively late and that their progression in the early stages of the disease is slow. A thorough cognitive assessment is a powerful tool and has a key role in the accurate and early diagnosis of dementia. It is very different from the cognitive testing usually seen in biomarker research and drug development. Yet the distinction between these approaches is unclear to many. This paper highlights the misconceptions around cognitive research in dementia and suggests a way forward to facilitate biomarker and drug development through the improved utility of cognitive assessment tools.