bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-organ Radiomics-Based Prediction of Future Remnant Liver Hypertrophy Following Portal Vein Embolization
Authors: Gerwing Mirjam , Schindler Philipp , Katou Shadi , Köhler Michael , Stamm Anna Christina , Schmidt Vanessa Franziska , Heindel Walter , Struecker Benjamin , Morgul Haluk , Pascher Andreas , Wildgruber Moritz , Masthoff Max 
Published: September 2023

Abstract
Background
Portal vein embolization (PVE) is used to induce remnant liver hypertrophy prior to major hepatectomy. The purpose of this study was to evaluate the predictive value of baseline computed tomography (CT) data for future remnant liver (FRL) hypertrophy after PVE.

Methods
In this retrospective study, all consecutive patients undergoing right-sided PVE with or without hepatic vein embolization between 2018 and 2021 were included. CT volumetry was performed before and after PVE to assess standardized FRL volume (sFRLV). Radiomic features were extracted from baseline CT after segmenting liver (without tumor), spleen and bone marrow. For selecting features that allow classification of response (hypertrophy ≥ 1.33), a stepwise dimension reduction was performed. Logistic regression models were fitted and selected features were tested for their predictive value. Decision curve analysis was performed on the test dataset.

Results
A total of 53 patients with liver tumor were included in this study. sFRLV increased significantly after PVE, with a mean hypertrophy of FRL of 1.5 ± 0.3-fold. sFRLV hypertrophy ≥ 1.33 was reached in 35 (66%) patients. Three independent radiomic features, i.e. liver-, spleen- and bone marrow-associated, differentiated well between responders and non-responders. A logistic regression model revealed the highest accuracy (area under the curve 0.875) for the prediction of response, with sensitivity of 1.0 and specificity of 0.5. Decision curve analysis revealed a positive net benefit when applying the model.

Conclusions
This proof-of-concept study provides first evidence of a potential predictive value of baseline multi-organ radiomics CT data for FRL hypertrophy after PVE.
Diseño y validación de un instrumento para evaluar comportamiento contraproducente online
Authors: Lupano Perugini María Laura , Castro Solano Alejandro 
Published: September 2023

El presente estudio tuvo como objetivo el diseño y validación de una escala para evaluar comportamiento contraproducente en línea que incluye el análisis conjunto de conductas destructivas (antisociales) y constructivas (prosociales). Además, se propuso determinar qué rasgos de personalidad (normales, patológicos, negativos o positivos) predicen dicho comportamiento. Participaron 351 sujetos de población general argentina (156 hombres, 191 mujeres, 2 se identificaron como no binarios), con una edad promedio de 39.35 años (de = 13.79). Para el cumplimiento de todos los objetivos, aparte de la prueba construida, se emplearon los siguientes instrumentos: Big Five Inventory, Personality Inventory for DSM-5 Brief-Form, Positive Traits Inventory Short-Form, Dark Triad Scale, y una encuesta diseñada ad hoc para evaluar el uso de internet y redes sociales. El análisis factorial exploratorio reveló una estructura de dos factores orientados a la evaluación de los dos tipos de conductas, que explicaban el 57.5 % de la varianza total. Como resultado, se dio lugar a una escala de 18 ítems con muy buenos valores de fiabilidad —coeficiente omega— (conductas destructivas ω = 0.88; conductas constructivas ω = 0.79). Por último, se realizaron análisis de regresión jerárquica que determinaron que los rasgos de la tríada oscura son los que mejor predicen el desarrollo de conductas destructivas, en tanto que los rasgos positivos predicen las conductas constructivas.
Service availability and readiness for hip fracture care in low- and middle-income countries in South and Southeast Asia
Authors: Tabu Irewin , Goh En L. , Appelbe Duncan , Parsons Nicholas , Lekamwasam Sarath , Lee Joon-Kiong , Amphansap Tanawat , Pandey Dipendra , Costa Matthew 
Published: September 2023

AimsThe aim of this study was to describe the current pathways of care for patients with a fracture of the hip in five low- and middle-income countries (LMIC) in South Asia (Nepal and Sri Lanka) and Southeast Asia (Malaysia, Thailand, and the Philippines).MethodsThe World Health Organization Service Availability and Readiness Assessment tool was used to collect data on the care of hip fractures in Malaysia, Thailand, the Philippines, Sri Lanka, and Nepal. Respondents were asked to provide details about the current pathway of care for patients with hip fracture, including pre-hospital transport, time to admission, time to surgery, and time to weightbearing, along with healthcare professionals involved at different stages of care, information on discharge, and patient follow-up.ResultsResponses were received from 98 representative hospitals across the five countries. Most hospitals were publicly funded. There was consistency in clinical pathways of care within country, but considerable variation between countries. Patients mostly travel to hospital via ambulance (both publicly- and privately-funded) or private transport, with only half arriving at hospital within 12 hours of their injury. Access to surgery was variable and time to surgery ranged between one day and more than five days. The majority of hospitals mobilized patients on the first or second day after surgery, but there was notable variation in postoperative weightbearing protocols. Senior medical input was variable and specialist orthogeriatric expertise was unavailable in most hospitals.ConclusionThis study provides the first step in mapping care pathways for patients with hip fracture in LMIC in South Asia. The previous lack of data in these countries hampers efforts to identify quality standards (key performance indicators) that are relevant to each different healthcare system.Cite this article: Bone Jt Open 2023;4(9):676–681.
Primary cerebral cystic echinococcosis in a child from Roman countryside: Source attribution and scoping review of cases from the literature
Authors: Casulli Adriano , Pane Stefania , Randi Franco , Scaramozzino Paola , Carvelli Andrea , Marras Carlo Efisio , Carai Andrea , Santoro Azzurra , Santolamazza Federica , Tamarozzi Francesca , Putignani Lorenza 
Published: September 2023

BackgroundHuman cystic echinococcosis (CE) is a zoonotic parasitic infection caused by the larval stage of the species belonging to theEchinococcus granulosus sensu lato(s.l.) complex. Parasitic cysts causing human CE are mainly localized in the liver and in the lungs. In a smaller number of cases, larvae may establish in any organ or tissue, including the central nervous system (CNS). Cerebral CE (CCE) is rare but poses serious clinical challenges.MethodsThis study presents a case of CCE in a child living in the countryside near Rome (Italy), along with a comparative molecular analysis of the isolated cyst specimens from the patient and sheep of local farms. We also systematically searched the literature to summarize the most relevant epidemiological and clinical aspects of this uncommon localization.FindingsThe comparative molecular analysis confirmed that the infection was caused byE.granulosus sensu stricto(s.s.) (G3 genotype), and most likely acquired in the family farm.The literature search identified 2,238 cases of CCE. In 80.51% of cases, brain was the only localization and single CCE cysts were present in 84.07% of cases. Mean patients’ age was 20 years and 70.46% were children. Cyst rupture was reported in 12.96% and recurrence of CCE after treatment in 9.61% of cases. Permanent disability was reported in 7.86% of cases, while death occurred in 6.21%. In case series reporting all CE localization, CCE represented 1.5% of all CE cases. In the few reports that identified at molecular level the CCE cyst,E.granulosus s.s. was found in 40% andE.canadensisin 60% of cases.ConclusionsWe report a rare case of CCE and evidenced the probable local origin of infection. The proportions of CE cases with uncommon localizations and with high impact on patients’ lives have been globally neglected and should be included in the computation of the global burden of CE.
Atypical Immunoglobulin A Vasculitis in a Pediatric Patient With Ulcerative Colitis
Authors: Desai Tejas S. , Jurencak Roman , Nair Asha , Carman Nicholas 
Published: September 2023

ABSTRACT
Rates of pediatric inflammatory bowel disease and biologic therapy use continue to rise. Consequently, specialists and generalists should recognize potential complications and side effects. We report the unique case of an adolescent with ulcerative colitis (UC) on vedolizumab presenting with severe abdominal pain, hematochezia, and subsequent purpura. After extensive investigation and a complex clinical course, diagnosis of atypical immunoglobulin A vasculitis was made. This is the first pediatric case of vasculitis in a patient with UC on vedolizumab and only the second reported case overall in UC. This case illustrates the emerging diagnostic challenge of distinguishing inflammatory bowel disease treatment complications from other common pediatric conditions.
INVESTIGAÇÃO DO PROCESSO EPIDÊMICO-EPIZOÓTICO DA FEBRE AMARELA NO SUDESTE BRASILEIRO NO PERÍODO DE 2016-2018
Authors: Silva Rafael Ramalho Cunha e , Oliveira Beatriz Fátima Alves de , Sobral Andréa 
Published: September 2023

Objetivo: O objetivo desse estudo foi investigar a relação da febre amarela - FA - com o clima e o ambiente, no processo epidêmico-epizoótico de 2016-2018 ocorrido na região Sudeste brasileira. Métodos: A análise dos dados foi realizada por meio de quatro abordagens: análise espacial da situação epidemiológica; clusters de casos humanos e espacialização das epizootias nos mesmos; identificação de fatores ambientais e climáticos; e a correlação do risco relativo dos clusters e os fatores identificados. Resultados: No período estudado, a maioria dos casos positivos da doença ocorreu no estado de Minas Gerais seguido por São Paulo. Os clusters foram detectados nos anos de 2017 e 2018. O período de estudo apresentou os maiores valores de temperatura e os menores de precipitação em comparação ao período climatológico de 20 anos de análise. A sazonalidade marca o padrão temporal da doença, onde a maioria dos casos ocorre entre dezembro e maio, além disso, surtos ocorrem com periodicidade irregular, quando o vírus encontra condições favoráveis para a transmissão. O espaço se encontra em transformação constante, onde o uso e cobertura do solo possui a maior porcentagem ligada às áreas rurais, seguido das áreas florestais. Os resultados mostraram uma correlação entre o risco relativo dos clusters como fatores ambientais e climáticos. Conclusão: Os resultados apontam para a correlação dos fatores climáticos e ambientais, junto com a presença de vetores e primatas não-humanos - PNHs - geraram um cenário de vulnerabilidade para a região Sudeste, no qual deve-se avaliar planos em relação a saúde pública para a vacinação da população e controle dos vetores urbanos, que podem fazer com que a FA urbana reemerja.
An atomistic study on the strain rate and temperature dependences of the plastic deformation Cu–Au core–shell nanowires: On the role of dislocations
Authors: Atiyah Ibrahim Abdulwahhab , Marhoon Ismail Ibrahim , Jawad Raed Kadhim Mohammed 
Published: September 2023

Abstract
Recently, Cu–Au core–shell nanowires have been extensively used as conductors, nanocatalysts, and aerospace instruments due to their excellent thermal and electrical conductivity. In experimental studies, various methods have been presented for producing, characterizing, and strengthening these structures. However, the mechanical behavior and plastic deformation mechanisms of these materials have not been investigated at the atomic scale. Consequently, in the present study, we carried out uniaxial tensile tests on Cu–Au nanowires at various tension rates and temperatures by means of the molecular dynamics approach. The Cu–Au interface was found to be the main site for nucleation of perfect dislocations, Shockley partials, and stacking faults due to the stress concentration and high potential energy arising from the atomic mismatch between shell and core layers. It was observed that an increase in the strain rate from 108 to 1,011 s−1 shortened the time required for the nucleation of dislocations, decreasing the dislocation density. This emphasizes that dislocation nucleation and slip mechanisms are time-dependent. Moreover, it was found that the interaction of Shockley partials can lead to the creation of lock dislocations, such as Hirth, Frank, and Stair-rod dislocations, imposing obstacles for the slip of other dislocations. However, as the tension temperature rose from 300 to 600 K, opposite-sign dislocations removed each other due to thermally activated mechanisms such as dislocation climb and dislocation recovery. Furthermore, the combination of Shockley partial dislocations decreased the stacking fault density, facilitating the plastic deformation of these structures. The yield strength and elastic modulus of the samples increased with the strain rate and substantially decreased as the temperature rose.
Heat transfer and pressure drop analysis of a microchannel heat sink using nanofluids for energy applications
Authors: Thakre Shekhar , Pandhare Amar , Malwe Prateek D. , Gupta Naveen , Kothare Chandrakant , Magade Pramod B. , Patel Anand , Meena Radhey Shyam , Veza Ibham , Natrayan L.  , Panchal Hitesh 
Published: September 2023

Abstract
The present research aims to enhance heat transfer in straight and wavy profile heat sinks using the same length and hydraulic diameter with different microchannel geometries (triangular, rectangular, trapezoidal, semi-circular, and circular) for uses in electronics, inkjet printing, high heat flux cooling of lasers, and other domains. The nanofluid employed is water/aluminum oxide (water/Al2O3), and the flow regime is laminar. The range of Reynolds number (Re) in this study was 220 ≤ Re ≤ 550, and the concentrations of nanoparticle Al2O3 with Heavy Water (2H2O) were 1.2 % volume. This investigation uses 3-dimensional Computational Fluid Dynamics (CFD) simulation software to investigate the heat transfer characteristics of several cross-sectioned microchannels. The numerical investigation utilizes the finite volume approach, and the CFD analysis is validated with accessible literature with different wavy profiles. According to the CFD simulation results, the microchannel with a circular cross-section has the highest heat transfer performance (up to 18 %) among the other cross-sections. The circular cross-section microchannel seemed to have the most significant increase in coolant temperature (by 9–22 %). The analysis outcomes prove that the microchannel with a circular cross-section has the highest performance for heat transfer; the triangular channel has the lowest performance under the same geometric parameters and boundary conditions. So, it is suggested that a circular microchannel can be used for a heat-carrying capacity of 150 W/cm2, a hydraulic diameter of 500 µm, and a Reynolds number equal to 500.
The crystal structure of 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino [3,2-a]isoquinolin-7-ium (E)-3-(4-nitrophenyl)acrylate pentahydrate, C29H34N2O13
Authors: Chen Shi-Yun , Wang Wei , He Yong , Yin Deng-ke 
Published: September 2023

Abstract
C29H34N2O13, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 8.1996(2) Å, b = 13.1993(3) Å, c = 13.5119(3) Å, α = 94.208(1)∘, β = 99.787(1)∘, γ = 90.247(1)∘, V = 1437.00(6) Å3, Z = 2, Rgt
(F) = 0.0457, wR

ref
(F
2) = 0.1218, T = 193 K.
Prenatal and adolescent alcohol exposure, neuroinflammation, and Alzheimer’s disease: a network meta analysis approach
Authors: Gerlikhman Lazer , Das Ujjal , Sarkar Dipak K. 
Published: September 2023

Abstract

Objectives
This review aims to determine the connection between developmental alcohol exposure and its potential impact on Alzheimer's disease (AD) later in life. We employ a network meta-analysis approach and examine gene fold changes from literature and Gene Expression Omnibus (GEO) datasets. Our goal is to investigate whether prenatal alcohol exposure (PAE) and/or adolescent alcohol exposure (AAE) could activate specific neuroinflammatory genes, potentially increasing the risk of AD development.

Content
We conducted a comprehensive analysis of brain datasets using a network meta-analysis approach. By synthesizing gene fold changes from literature and GEO datasets, we examined the potential impact of developmental alcohol exposure on increased risk of developing AD in the future.

Summary
Our findings reveal significant associations between alcohol exposure and critical functional categories and diseases in the brain. Alcohol exposure was strongly linked to the “Inflammatory Response” and “Nervous System Development and Function” categories, indicative of inflammatory reactions in the brain and detrimental effects on nervous system integrity. Furthermore, we observed links with “Organismal Injury and Abnormalities” and “Cell Death and Survival.” Pathway analysis revealed dysregulation in neuroinflammatory, ERK/MAPK signaling, amyloid processing, IL-1 signaling and calcium signaling pathways, suggesting their potential involvement in alcohol-induced neurotoxicity.

Outlook
This review highlights the necessity of recognizing developmental alcohol exposure as a potential risk factor for AD and shed light on the underlying mechanisms that may contribute to alcohol-induced neurotoxicity. By expanding our understanding of these mechanisms, we can better address the complex relationship between developmental alcohol exposure and neurodegenerative disorders like AD.
Dynamic characteristics of open-ends squeeze film dampers with air ingestion
Authors: Tang Zhenhuan , Chen Xi , Zhou Hailun , Lu Yu , He Hongbin 
Published: September 2023

Abstract
In order to explore the air ingestion characteristics of the open-ends squeeze film dampers (SFD), a 3D computational fluid dynamics solution model of the SFD was proposed based. The setting of opening boundary conditions was considered, which was verified experimentally by the bidirectional excitation. The results revealed that with the same precession frequency, the smaller radial clearance leads to the greater oil film damping. An increasing oil supply and oil holes led to the smaller air ingestion range at the end. The design guideline for the open-ends SFD was investigated in the present work.
Schüler:innen im Religionsunterricht. Heuristische Annäherungen an die Konstruktion des religionspädagogischen Schülerbildes
Authors: Krimmer Evelyn 
Published: September 2023

Zusammenfassung
Der Beitrag fragt danach, inwiefern konstruktivistisch geprägte Erkenntnisprozesse nicht auch hinsichtlich der Frage eine Rolle spielen, auf welche Weise von Seiten der Religionspädagog:innen in Theorie und Praxis über Schüler:innen gedacht und welches implizite Schülerbild somit meist unbewusst konstruiert wird. Im Sinne einer Heuristik werden drei Konstruktionsdimensionen vorgeschlagen, die den Konstruktionsprozess eines religionspädagogischen Schülerbildes maßgeblich mitbeeinflussen. Schließlich wird die Frage aufgeworfen, inwiefern ein Schülerbild im Kontext religionspädagogischer und -didaktischer Vollzüge wirksam ist und daher als ein Impetus zur religionspädagogischen Selbstreflexion wahrgenommen werden sollte.
Synapse-Enriched m6A-Modified Malat1 Interacts with the Novel m6A Reader, DPYSL2, and Is Required for Fear-Extinction Memory
Authors: Madugalle Sachithrani U. , Liau Wei-Siang , Zhao Qiongyi , Li Xiang , Gong Hao , Marshall Paul R. , Periyakaruppiah Ambika , Zajaczkowski Esmi L. , Leighton Laura J. , Ren Haobin , Musgrove Mason R. B. , Davies Joshua W. A. , Kim Gwangmin , Rauch Simone , He Chuan , Dickinson Bryan C. , Fulopova Barbora , Fletcher Lee N. , Williams Stephen R. , Spitale Robert C. , Bredy Timothy W. 
Published: September 2023

The RNA modification N6-methyladenosine (m6A) regulates the interaction between RNA and various RNA binding proteins within the nucleus and other subcellular compartments and has recently been shown to be involved in experience-dependent plasticity, learning, and memory. Using m6A RNA-sequencing, we have discovered a distinct population of learning-related m6A- modified RNAs at the synapse, which includes the long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1). RNA immunoprecipitation and mass spectrometry revealed 12 new synapse-specific learning-induced m6A readers in the mPFC of male C57/BL6 mice, with m6A-modifiedMalat1binding to a subset of these, including CYFIP2 and DPYSL2. In addition, a cell type- and synapse-specific, and state-dependent, reduction of m6A onMalat1impairs fear-extinction memory; an effect that likely occurs through a disruption in the interaction betweenMalat1and DPYSL2 and an associated decrease in dendritic spine formation. These findings highlight the critical role of m6A in regulating the functional state of RNA during the consolidation of fear-extinction memory, and expand the repertoire of experience-dependent m6A readers in the synaptic compartment.SIGNIFICANCE STATEMENTWe have discovered that learning-induced m6A-modified RNA (including the long noncoding RNA,Malat1) accumulates in the synaptic compartment. We have identified several new m6A readers that are associated with fear extinction learning and demonstrate a causal relationship between m6A-modifiedMalat1and the formation of fear-extinction memory. These findings highlight the role of m6A in regulating the functional state of an RNA during memory formation and expand the repertoire of experience-dependent m6A readers in the synaptic compartment.
The Role of Ethnic Identity in Overcoming Discrimination Against Ethnic Minorities and Politics in Indonesia
Authors: Setiawan Refly , Buana Dana Riksa , Tanjung Indah Pratiwi 
Published: September 2023

Indonesia has a wide variety of ethnic, so it is very vulnerable to various conflicts such as discriminatory treatment of ethnic minorities. Despite laws prohibiting racial and ethnic discrimination, discriminatory acts still occur in some parts of Indonesia. Discrimination against ethnic minorities is a serious and complex problem and can take many forms, such as unfair treatment, negative stereotypes, exclusion, restrictions on access to resources and opportunities, and acts of violence and persecution that harm ethnic minorities. Some ethnic minorities that often experience discrimination in Indonesia include ethnic Chinese, Papuans, Dayaks, and several other ethnicities. One of the main causes of ethnic discrimination is due to prejudices and stereotypes that develop in society. These stereotypes often lead to the exclusion of ethnic minorities. Ethnic identity plays an important role in shaping perceptions, attitudes, and behaviors of individuals and groups, and can provide valuable insights for the management and handling of issues of ethnic discrimination. This can be the focus of research to identify how the role of ethnic identity can provide a deeper understanding of how ethnic identity can be used as a tool in addressing ethnic minority discrimination. The method in this study is qualitative descriptive with data collection techniques through literature studies such as journals, textbooks, handbooks, notes, and appendices related to the research topic, and the data analysis using content analysis. The results showed that to overcome the problem of ethnic discrimination, collective efforts from various parties are needed. In this regard, the role of media and education is very important to build awareness about diversity and reduce negative stereotypes. It is hoped that with awareness and cooperation from various parties, ethnic discrimination in Indonesia can be reduced and eliminated gradually.Keywords: Identity, Ethnicity, Discrimination, Stereotype, Minority