bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between SPISE and NAFLD in patients with type 2 diabetes
Authors: Zhao Hongyan , Ji Baolan , Wang Xin , Shi Shuwei , Sheng Jie , Ma Xuan , Ban Bo , Gao Guanqi 
Published: January 2025

AimsNon-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point insulin sensitivity estimator (SPISE) is a novel index. This study aims to explore the association between SPISE and NAFLD in T2D population.MethodsThis study included a total of 2,459 patients with T2D. SPISE was calculated based on high density lipoprotein-cholesterol (HDL-c), triglycerides (TG), and body mass index (BMI). Participants were categorized into NAFLD and non-NAFLD groups based on the results of ultrasonographic diagnosis. The relationship between SPISE and NAFLD was analyzed separately for each gender.ResultsThe overall prevalence of NAFLD is 38.5%. In females and males, the SPISE was significantly reduced in the NAFLD group compared to the non-NAFLD group (both P &lt; 0.05). The prevalence of NAFLD showed a significant reduction across quartiles of the SPISE in both genders (both P &lt; 0.05).Additionally, univariate correlation analysis showed a negative correlation between SPISE and NAFLD (both P &lt; 0.05). In multivariate regression analysis, a reduced SPISE was identified as an independent risk factor for NAFLD (odds ratios of 0.572 and 0.737, 95% CI of 0.477–0.687 and 0.587–0.926, respectively).Moreover, the area under the receiver operating characteristic (ROC) curve for SPISE was 0.209 in females and 0.268 in males (95% CI of 0.175–0.244 and 0.216–0.320, respectively). These results are more meaningful than those of other variables.ConclusionSPISE is significantly reduced in NAFLD patients with T2D. Compared to other indicators, SPISE demonstrates superior predictive value in diagnosing NAFLD, and it is independent of gender.
Effect of transcutaneous electrical acupoint stimulation on length of stay for patients after undergoing surgery for colorectal cancer: a systematic review and meta-analysis of randomized controlled trials
Authors: Xiao YaDan , Yang Fei , Zhou JunLiang , Huang YuanLing , Xiao YaXin 
Published: January 2025

ObjectiveThis study aimed to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on the length of stay (LOS) of patients undergoing surgery for colorectal cancer.MethodsA systematic review was conducted by searching databases, including PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, and Wanfang Database for randomized controlled trials (RCTs) published up to August 24, 2024. Statistical analyses were performed using the Cochrane Collaboration Review Manager (RevMan 5.4). The quality of the RCTs was assessed using the Cochrane Systematic Review Handbook 5.1 and its recommended risk-of-bias assessment tool. Two independent investigators screened and extracted the data and performed statistical analysis.ResultsSeven RCTs were included in the analysis. The findings indicated that TEAS significantly reduced the LOS of patients undergoing surgery for colorectal cancer (mean difference = −1.36, 95% confidence interval = −1.95 to −0.78, p &lt; 0.00001). Subgroup analyses of outcome measures, intervention methods, and intervention time points demonstrate the significant effect of TEAS on reducing LOS.ConclusionTEAS effectively shortens the LOS of patients undergoing surgery for colorectal cancer. Future studies should focus on refining TEAS protocols and exploring their effects on other aspects of postoperative recovery to fully establish their roles in perioperative management.
Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024
Authors: Gainollina Gulnur G. , Jakanov Murat K. , Zhakiev Bazylbek S. , Karsakbayev Uteugaly G. , Taishibayev Kairat R. , Kurmanbayev Bulat A. 
Published: January 2025

BackgroundThis study aims to analyzing scientific publications related to necrotizing pancreatitis and its mortality, identifying key areas and trends, and determining the leading research institutions, authors, countries, and journals actively working in this field.MethodsThe Web of Science and Scopus databases were searched for articles on NP published between January 1, 2013, and April 22, 2024. Articles published before 2013, conference abstracts, and case reports were excluded. The articles were assessed based on various metrics, including the number of citations, publication dates, countries of origin, institutions, journals, and authors.ResultsA total of 929 articles were identified, of which 251 were deemed suitable for analysis after duplicates were removed. China contributed the most articles, followed by the United States and India. The most frequent publications appeared in specialized journals such as “Pancreatology” and “Journal of Gastrointestinal Surgery.” The primary research institutions were universities and medical centers. The highest-impact articles focused on minimally invasive treatment methods for NP. There has been a growing body of research in NP over the past decade, particularly in China and the United States.ConclusionDespite advancements in medical science, the mortality rate associated with pancreatic necrosis remains high. This highlights the continued challenge in effectively addressing complications of acute pancreatitis. Researchers worldwide are actively exploring alternative therapeutic approaches to mitigate these complications and improve patient outcomes.
Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial
Authors: Son Ji Won , Kang Purum , Min Sun Seek , Seol Geun Hee 
Published: January 2025

BackgroundDiabetic foot ulcer (DFU) is a significant global health concern due to its substantial burden on individuals and healthcare systems. In addition to its physical impact, DFU has emotional effects on patients. This study analyzed the effects of inhaling clary sage (CS; Salvia sclarea L.) or linalyl acetate (LA) on depression and psychological factors in patients with DFU.MethodsThis study, performed at the Diabetic Wound Center, enrolled DFU patients, categorized as having mild or moderate to severe depression based on visual analog scale (VAS) for depression scores. Patients were randomized to inhalation of 5% CS oil, 5% LA or almond oil (control) by natural breathing. Blood pressure, heart rate, Depression-VAS, Anxiety-VAS, and Stress-VAS were measured before and after inhalation.ResultsThis study enrolled 72 patients with DFU, including 43 with mild and 29 with moderate to severe depression. Of the 43 patients with mild depression, 14, 14, and 15 were randomized to inhalation of CS, LA, and almond oil, respectively. Of the 29 patients with moderate to severe depression, 9, 11, and 9 were randomized to inhalation of CS, LA, and almond oil, respectively. Compared with inhalation of almond oil, inhalation of CS oil significantly reduced stress (p &lt; 0.05) and (p &lt; 0.01) in patients with mild depression, whereas inhalation of LA significantly reduced anxiety-VAS (p &lt; 0.05) and depression-VAS (p &lt; 0.05) in patients with moderate to severe depression.ConclusionInhalation of CS oil may have the potential to alleviate stress and anxiety in DFU patients with mild depression, whereas inhalation of LA may have the potential to alleviate anxiety and depression in DFU patients with moderate to severe depression. These findings suggest that adjunct therapy in DFU patients should be individualized according to the degree of depression.Clinical trial registrationhttp://cris.nih.go.kr/, identifier KCT0009722.
Intrauterine death from placental abruption: influence of labor duration and mode of delivery on maternal outcomes
Authors: Van Hees Louis , Danger Robin , Turbelin Caroline 
Published: January 2025

IntroductionIntrauterine fetal death (IUFD) caused by retroplacental hematoma (RPH) can lead to serious maternal complications including coagulopathies and hemorrhage. A prolonged diagnostic-to-expulsion delay may increase coagulation risks. Vaginal delivery (VD) prolongs this delay, while cesarean delivery poses higher hemorrhagic risks. This study aimed to assess the relationship between expulsion delay and complications, identify a time threshold for increased risks, and evaluate VD feasibility.Material and methodsWe conducted a retrospective single-center study at the University Hospital of Martinique, including all patients presenting with RPH and IUFD between January 2003 and December 2022. Complications were defined by a composite criterion, including the need for blood transfusion, severe anemia or admission to an intensive care unit.ResultsVD was attempted in 26 of the 27 patients included and successfully achieved in 85% of the cases. All cesarean deliveries resulted in complications (p = 0.12), with 50% experiencing severe hemorrhage, compared to 21.7% of VD cases (p = 0.23). No statistically significant association was found between the expulsion delay and the occurrence of complications (p = 0.20). A low fibrinogen level upon admission was associated with an increased risk of severe hemorrhage (p = 0.01) and complications (p = 0.01).ConclusionIn this study, no evidence was found to suggest an association between the diagnostic-to-expulsion interval and maternal complications. Low fibrinogen levels at admission appear to be a prognostic factor for severe hemorrhage and could have therapeutic implications. Vaginal delivery remains feasible even in the presence of coagulopathies at admission.
Tablet-based self assessment memory scale-revised (SAMS-R) evaluates memory functions for older adults
Authors: Kowa Hisatomo , Kumagai Ryoko , Oki Yutaro , Imamura Miki , Suzuki Yuka 
Published: January 2025

BackgroundThe demand for more accurate and early diagnosis of mild cognitive impairment (MCI) patients due to Alzheimer’s disease (AD) has increased after disease-modifying drugs were launched. Among these needs, there is a requirement for tools that can easily assess the ability to recall memories, which changes early in the disease.ObjectivesWe established Self Assessment Memory Scale (SAMS) method before, which includes 8-picture recall test and 16-word recognition test. We adopted this method to software that can be operated on a tablet computer so that participants can perform the method independently. The purpose of this study was to validate this method.DesignCross sectional research.SettingSome of the participants were recruited from hospitals for patients diagnosed with AD or MCI. The others were recruited from three regional cohorts of healthy older adults.ParticipantsThe total number of participants was 304 (20 of whom had AD or MCI), and the mean age was 71.2 years. 64% of the participants were women.MeasurementsWe used the logical memory subtest of the WMS-R as the standard for memory evaluation and assessed the relationship between this score and the SAMS score calculated by the software.ResultsThe 2nd SAMS score were higher than the 1st SAMS score in some participants, on the other hand, the intraclass correlation coefficient was good. Since the number of false recognition in the 16-word recognition test was higher in participants with lower LM II scores, we developed a new score to reflect the ratio of false recognition, SAMS-R, and we observed it has good correlation with LM II. The mean SAMS-R score decreased gradually after the age of 65 years, indicating that age-related changes in memory recall can be detected. The ROC curve analysis was conducted to evaluate the detectability to determine whether if the WMS-R LM II score is above or below 10, showing that the AUC was greater than 0.9.ConclusionSAMS-R, which can be performed on a tablet literally by himself/herself independently, shows a high correlation with the WMS-R Logical Memory II score, and has the advantage of being performed in a short time without the need for a clinical psychologist or other personnel.
Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury
Authors: Walling Ian , Baumgartner Sarah , Patel Mitesh , Crone Steven A. 
Published: January 2025

IntroductionSpinal cord injury in the high cervical cord can impair breathing due to disruption of pathways between brainstem respiratory centers and respiratory motor neurons in the spinal cord. Electrical stimulation of limb afferents can increase ventilation in healthy humans and animals, but it is not known if limb afferent stimulation can improve breathing following a cervical injury.MethodsWe stimulated the sciatic nerve while using electromyography to measure diaphragm function in anesthetized mice following a cervical (C2) hemisection spinal cord injury, as well as in uninjured controls. The amplitude and frequency of inspiratory bursts was analyzed over a range of stimulation thresholds.ResultsWe show that electrical stimulation (at sufficient current thresholds) of either the left or right sciatic nerve could restore inspiratory activity to the previously paralyzed diaphragm ipsilateral to a C2 hemisection injury at either acute (1 day) or chronic (2 months) stages after injury. We also show that sciatic nerve stimulation can increase the frequency and amplitude of diaphragm inspiratory bursts in uninjured mice.DiscussionOur findings indicate that therapies targeting limb afferents could potentially be used to improve breathing in patients with cervical spinal cord injury and provide an experimental model to further investigate the neural pathways by which limb afferents can increase respiratory muscle activity.
Evolution in optical molecular imaging techniques guided nerve imaging from 2009 to 2023: a bibliometric and visualization analysis
Authors: Liang Wenkai , Liu Yan , Jia Erlong , Yang Xiaofeng , Han Shufeng , Wei Jinzheng , Zhao Wei 
Published: January 2025

BackgroundRecent years, the use of optical molecular imaging (OMI) techniques guided nerve imaging has made significant progress. However, a comprehensive bibliometric analysis in this field is currently lacking. In this study, we aim to shed light on the current status, identify the emerging hot topics, and provide valuable insights for researchers within this field.MethodsIn this study, we collected 414 research via the Web of Science Core Collection (WoSCC) from 2009 to 2023. CiteSpace, VOSviewer and R package “bibliometrix” were used for analysis of countries, institutions, journals, etc., to evaluate the trends.ResultsThe amounts of publications in relation to OMI guided nerve imaging has been increasing. United States and China contributed to over 60% of the publications. The Shanghai Jiao Tong University contributed the highest number of publications. Investigative Ophthalmology and Visual Science is considered the most prestigious and prolific journal in the field. It is also widely regarded as the most cited journal. Among the top 10 authors in terms of output, Hehir CAT has the highest number of citations. The “neurosciences neurology,” “science technology other topics,” and “ophthalmology” are representative research areas. The main cluster of keywords in this field includes “axonal regeneration,” “mouse,” and “optical coherence tomography.”ConclusionThis bibliometric investigation offers a comprehensive portrayal of the structure of knowledge and the progression patterns, presents an all-encompassing synthesis of findings, discerns and illustrates the forefront within OMI guided nerve imaging for the first time. It will provide a valuable reference for relevant scholars.
Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy
Authors: He Han-han , Zhang Xiao-ge , Chen Fen-fang 
Published: January 2025

BackgroundEpilepsy, a common neurological disorder, is characterized by susceptibility to recurrent seizures. Increasing evidence suggests that autophagy plays a crucial role in the initiation and progression of epilepsy. However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. Differential expression genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA) were employed to screen for autophagy related differential expression genes (ARDEGs) in GSE143272 database. Subsequently, protein–protein interaction, transcription factors and miRNAs networks were constructed. Additionally, the functional enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied. The hub ARDEGs were identified through CytoHubba, followed by the LASSO analysis. The Immune Cell Abundance Identifier (ImmuCellAI) was used to estimate peripheral immune cells abundance of epilepsy. Furthermore, the expression level of hub ARDEGs were detected in patients treated with different epilepsy monotherapies to explore the role of autophagy in the responsiveness of antiepileptic drug therapy. Finally, the expression level of hub ARDEGs were further validated in hippocampus of GSE256068 to enhance the reliability of the results.ResultsTwenty ARDEGs in epilepsy were screened out by integrating DEGs and WGCNA analysis. KEGG enrichment analysis showed that the ARDEGs in epilepsy were not only involved in the autophagy, but also apoptosis, the NOD-like receptor signaling pathway, the neurotrophin signaling pathway, etc. Four hub ARDEGs (PIK3R1, TRIM21, TRIM22, and ITPR3) were screened through integrating CytoHubba plug and LASSO analysis. The immune infiltration analysis showed that there was a significantly increased abundance of macrophages and a decreased abundance of CD4 and CD8 T cells, including Tr1, nTreg, Tfh, CD8 naïve, cytotoxic T cells and effector memory T cells in the epilepsy group. Furthermore, the hub ARDEGs were significantly correlated with the abundance of differential immune cells. In expression level validation and anti-epileptic drug responsiveness analysis, PIK3R1 and ITPR3 had significant differences in the hippocampus of patients with epilepsy. PIK3R1 expression level was found to be related with carbamazepine resistance.ConclusionThis study elucidated the autophagy-related gene signatures in epilepsy and clarified their association with immune infiltration and anti-epileptic drug responsiveness, providing a novel target for future therapeutic interventions and disease markers in epilepsy.
Taichi on the brain: an activation likelihood estimated meta-analysis of functional neuroimaging data
Authors: Wang Shengxin , Liu Tianyu , Du Jingtao , Chen Jun , Luo Xiufen , Meng Yujie , Zeng Chun , Zhang Xupeng , Shao Binghua 
Published: January 2025

IntroductionTai Chi Chuan (TCC) is an exercise regimen renowned for its comprehensive benefits to both physical and mental health. The present research endeavor aims to elucidate the neurocognitive impacts of TCC compared to alternative exercise modalities or therapeutic interventions.MethodsA systematic meta-analysis was undertaken, encompassing a rigorous review of diverse datasets, wherein 422 scholarly articles were examined, with a subset of 18 articles meeting the stringent criteria for inclusion in the analytical framework.ResultsThe study cohort comprised 677 participants, characterized by a mean age of 56.52 ± 14.89 years and an average educational attainment of 11.06 ± 3.32 years. Noteworthy alterations in functional neural activity were identified within the superior frontal gyrus.DiscussionThis comprehensive analysis provides significant insights into the enduring neural modifications and the distinctive contributions of TCC to cognitive health. Nevertheless, it is imperative to acknowledge the potential for bias in smaller functional magnetic resonance imaging studies owing to their inconclusive outcomes. This observation underscores the critical need for collaborative, multicenter research initiatives with expanded sample sizes to enhance the robustness and generalizability of future findings.
Factors influencing waist circumference among urban bank employees in Northeast Ethiopia: a cross-sectional study
Authors: Yimer Woynshet , Asmare Lakew , Gebeyehu Fikre Bayu , Alemu Tihtna , Mehamed Anisa , Yeshanew Ayele Fanos 
Published: January 2025

IntroductionA widely recognized public health issue affecting people worldwide is central obesity. Numerous chronic conditions, such as type 2 diabetes mellitus, cardiovascular disease, and malignancies are linked to this syndrome. There is limited information about waist circumference (WC) and its related variables among urban bank workers in Ethiopia. Therefore, the purpose of this study was to evaluate waist circumference and the factors associated with it among bank workers in Northeast Ethiopia.MethodsAn institution-based cross-sectional study was carried out in Dessie, Northeast Ethiopia, between 2 October 2023 and 24 October 2023. A random selection method was employed to select 363 bank workers. STATA version 17 was used for analysis after the data were imported into EpiData version 4.4.2.0. Univariate and multivariate linear regression analyzes were performed to identify factors related to waist circumference. Normality, homoscedasticity, significant outliers, and multicollinearity were assessed, and a p-value of less than 0.05, along with a 95% confidence interval, was considered statistically significant.ResultsA total of 345 participants were included in the final analysis, with a 95% response rate. The overall mean ± standard deviation (SD) of the waist circumference of the employees was 81.7 ± 6.8 cm, with 82.4 ± 6.5 cm for men and 80.7 ± 7.2 cm for women. The overall prevalence of central obesity was 57.7%, with 48.2% for the men and 70.3% for the women. The overall mean ± SD of the waist-to-hip ratio (WHR) was 0.90 ± 0.05, with 0.91 ± 0.04 for men and 0.89 ± 0.05 for women. The average waist circumference was significantly associated with the participants’ age (0.2 cm per year (SE: 0.1)) and MET hours (0.2 cm (SE: 0.1)). The mean waist circumference was 2.7 cm (SE:0.8) higher in the married women, 4.6 cm (SE:1.9) higher in the participants with non-communicable diseases (NCDs), and 1.7 cm (SE:0.8) higher in the participants who consumed discretionary calories for 4 days/week.ConclusionThe mean waist circumference among bank employees was higher, with more than half of the participants having central obesity. Age, marital status, discretionary calorie intake, non-communicable diseases, and metabolic equivalence task hours were the significant factors of waist circumference. Therefore, promoting activities aimed at preventing non-communicable diseases, such as leisure-time physical activity, and reducing discretionary calorie intake are essential for reducing high waist circumference measurements.