bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the learning curve for percutaneous endoscopic lumbar interbody fusion for lumbar degenerative diseases
Authors: Zhao Tingxiao , Dai Zhanqiu , Zhang Jun , Huang Yazeng , Shao Haiyu 
Published: March 2023

Abstract
Purpose
Percutaneous endoscopic lumbar interbody fusion (PELIF) is one of the least invasive procedures for lumbar degenerative disorders (LDD). There is limited knowledge of the learning curve for PELIF.

Methods
A total of 93 consecutive patients who underwent PELIF performed by a single spine surgeon for LDD failed with conservative treatment were retrospectively reviewed. The case series was split into three groups based on timing: A (earliest third of patients); B (middle third of patients); and C (latest third of patients). The following were also recorded: operating time, X-ray exposure time, complications, radiologic fusion rates, pre- and postoperative patient-reported outcome measures (PROMs) scores (visual analogue scale (VAS) for back pain, VAS for leg pain, Japanese Orthopaedic Association, Oswestry Disability Index and MacNab criteria), length of hospital stay, and need for revision surgeries. A learning curve was then developed by a logarithmic curve-fit regression analysis.

Results
The operative time gradually decreased over time, and an asymptote was reached after about 25 cases. Compared with group B or C, group A had significantly longer operative time, significantly longer length of hospital stay, needed significantly more x-ray exposure time. Though not significantly different, there are fewer complications and revision surgeries over time. There is no significant difference over time in PROMs scores except for the VAS back scores.

Conclusions
PELIF is an alternative for minimal invasive surgery for LDD, PELIF presents a learning curve to the practicing spine surgeon with regard to operative time, x-ray exposure time, length of hospital stay, clinical PROMs and radiographic outcomes and complications. The presented PELIF learning curve provided valuable insight to surgeons interested in performing this surgery.
Deep eutectic solvent-based manganese dioxide nanosheets composites for determination of DNA by a colorimetric method
Authors: Xu Jia , Yang Yuan , Du Juan , Lu Hui , Gao Wenqi , Gong Hongjian , HanXiao  
Published: March 2023

Abstract
Background
Nucleic acid is the carrier of genetic information and the keymolecule in life science. It is important to establish a simple and feasible method for nucleic acid quantification in complex biological samples.

Methods
Four kinds of hydrogen bond acceptors (choline chloride (ChCl), L-carnitine, tetrabutylammonium chloride (TBAC) and cetyltrimethylammonium bromide (CTAB)) were used to synthesize deep eutectic solvents (DESs) with hexafluoroisopropanol (HFIP). DESs based manganese dioxide (MnO2) nanosheets composites was synthesized and characterized. DNA concentration was determined by a UVVis spectrometer. The mechanism of DNA-DES/MnO2 colorimetric system was further discussed.

Results
The composite composed of DES/MnO2 exhibited excellent oxidase-like activity and could oxidize 3,3’,5,5’ -tetramethylbenzidine (TMB) to produce a clear blue change with an absorbance maximum at 652 nm. When DNA is introduced, the DNA can interact with the DES by hydrogen bonding and electrostatic interactions, thereby inhibiting the color reaction of DES/MnO2 with TMB. After condition optimization, ChCl/HFIP DES in 1:3 molar ratio was used for the colorimetric method of DNA determination. The linear range of DNA was 10–130 µg/mL and exhibited good selectivity.

Conclusion
A colorimetric method based on DES/MnO2 was developed to quantify the DNA concentration. The proposed method can be successfully used to quantify DNA in bovine serum samples.
Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial
Authors: Daix Thomas , Mathonnet Armelle , Brakenridge Scott , Dequin Pierre-François , Mira Jean-Paul , Berbille Frederique , Morre Michel , Jeannet Robin , Blood Teresa , Unsinger Jacqueline , Blood Jane , Walton Andrew , Moldawer Lyle L. , Hotchkiss Richard , François Bruno 
Published: March 2023

Abstract
Background
Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated recombinant human IL-7, administered intramuscularly reversed sepsis-induced lymphopenia and improved lymphocyte function. Thepresent study evaluated intravenous administration of CYT107. This prospective, double-blinded, placebo-controlled trial was designed to enroll 40 sepsis patients, randomized 3:1 to CYT107 (10 µg/kg) or placebo, for up to 90 days.

Results
Twenty-one patients were enrolled (fifteen CYT107 group, six placebo group) at eight French and two US sites. The study was halted early because three of fifteen patients receiving intravenous CYT107 developed fever and respiratory distress approximately 5–8 h after drug administration. Intravenous administration of CYT107 resulted in a two–threefold increase in absolute lymphocyte counts (including in both CD4+ and CD8+ T cells (all p < 0.05)) compared to placebo. This increase was similar to that seen with intramuscular administration of CYT107, was maintained throughout follow-up, reversed severe lymphopenia and was associated with increase in organ support free days (OSFD). However, intravenous CYT107 produced an approximately 100-fold increase in CYT107 blood concentration compared with intramuscular CYT107. No cytokine storm and no formation of antibodies to CYT107 were observed.

Conclusion
Intravenous CYT107 reversed sepsis-induced lymphopenia. However, compared to intramuscular CYT107 administration, it was associated with transient respiratory distress without long-term sequelae. Because of equivalent positive laboratory and clinical responses, more favorable pharmacokinetics, and better patient tolerability, intramuscular administration of CYT107 is preferable.
Trial registration: Clinicaltrials.gov, NCT03821038. Registered 29 January 2019, https://clinicaltrials.gov/ct2/show/NCT03821038?term=NCT03821038&draw=2&rank=1.

Graphical Abstract
Effect of illness perceptions on asthma control and quality of life amongst adult outpatients with asthma in China
Authors: Cai Qingqing , Jin Meiling , Li Xiaoyu , Zhang Jieqing , Xu Qing , Ye Ling , Lyu Qianzhou 
Published: March 2023

Abstract
Objective
To investigated the influence of illness perceptions and other risk factors related to poor asthma control and quality of life in adult outpatients with asthma in China.

Methods
Patients with a confirmed asthma diagnosis were recruited from the outpatient clinic at Zhongshan Hospital, Fudan University in Shanghai. Sociodemographic, psychological, and asthma related variables were assessed in all participants. Patients’ illness perceptions, medication adherence, asthma control, and quality of life were assessed using validated questionnaires, such as the Brief Illness Perception Questionnaire, Medication Adherence Rating Scale (MARS-A), the Asthma Control Test, and the Mini Asthma Quality of Life Questionnaire. Multiple linear regressions and logistic regressions were used to examine the associations between illness perceptions, medication adherence behaviors, and disease outcome (i.e., asthma control and quality of life).

Results
A total of two hundred thirty-one (231) outpatients with asthma were included in this cross-sectional study, 80 of whom (34.6%) had asthma that was uncontrolled. Patients who perceived their life (β = − 0.197, p < 0.001) and emotions (β = − 0.294, p < 0.001) as severely affected by the illness were more likely to have a lower quality of life, findings that were statistically significant. Also, patients who believed they had a higher degree of personal control over their illness (β = 0.333, p < 0.001), and had better medication adherence (β = 0.250, p < 0.001) were found to have a better quality of life.

Conclusion
Our study indicated that illness perceptions and medication adherence have a significant impact on disease outcome. Both of these factors should be considered when determining the best health care practices or constructing a predictive intervention model for patients with uncontrolled asthma.
Deep reinforcement learning for data-efficient weakly supervised business process anomaly detection
Authors: Elaziz Eman Abd , Fathalla Radwa , Shaheen Mohamed 
Published: March 2023

AbstractThe detection of anomalous behavior in business process data is a crucial task for preventing failures that may jeopardize the performance of any organization. Supervised learning techniques are impracticable because of the difficulties of gathering huge amounts of labeled business process anomaly data. For this reason, unsupervised learning techniques and semi-supervised learning approaches trained on entirely labeled normal data have dominated this domain for a long time. However, these methods do not work well because of the absence of prior knowledge of true anomalies. In this study, we propose a deep weakly supervised reinforcement learning-based approach to identify anomalies in business processes by leveraging limited labeled anomaly data. The proposed approach is intended to use a small collection of labeled anomalous data while exploring a huge set of unlabeled data to find new classes of anomalies that are outside the scope of the labeled anomalous data. We created a unique reward function that combined the supervisory signal supplied by a variational autoencoder trained on unlabeled data with the supervisory signal provided by the environment’s reward. To further reduce data deficiency, we introduced a sampling method to allow the effective exploration of the unlabeled data and to address the imbalanced data problem, which is a common problem in the anomaly detection field. This approach depends on the proximity between the data samples in the latent space of the variational autoencoder. Furthermore, to efficiently model the sequential nature of business process data and to handle the long-term dependences, we used a long short-term memory network combined with a self-attention mechanism to develop the agent of our reinforcement learning model. Multiple scenarios were used to test the proposed approach on real-world and synthetic datasets. The findings revealed that the proposed approach outperformed five competing approaches by efficiently using the few available anomalous examples.
Climate Change Impacts and Environmental and Water use Behaviors, Beliefs and Perceptions
Authors: BANOO Ismail , DORASAMY Nirmala , BUX Faizal 
Published: March 2023

This paper presents research conducted on urban home water use behavior as a response demand mitigation strategy to reduce domestic water consumption in SA. The paper presents results of urban home residents’ attitudes, behavior and perceptions towards their water consumption in a search for ways in which domestic demand for water may be substantially reduced. The analysis reflects the water use behavior and perceptions of urban dwellers in a period where water use rationing and restrictions are in place in parts of SA, therefore water scarcity is an important public crisis issue.
The research has brought to the fore the complexity of the forces shaping water demand and use in the context of the socio-demographic composition of homes residing in different types of dwellings, as well as the cultural, behavioral and attitudinal aspects of water consumption in city of Durban. The essential questions driving the research was what extent the two key dimensions of urban structure do, i.e. built form and the socio-behavioral characteristics of home water use, influence the pattern of water consumption. Additionally, the study ascertained the extent to which urban water users understood water-saving practices and the need to conserve this precious natural resource whilst also investigating the extent that the public believed were the most effective water-saving habits, interventions and communication methods to support reduced water consumption at a home level. In so doing, the study findings have aimed to inform public policy on ways to reduce consumption and identify alternative and complimentary ways to address the urban water conservation and demand management planning.
Sustainable Development of Rural Areas in the Conditions of Globalization: Ukrainian Realities
Authors: LISOVA Tetiana , SHARAPOVA Svitlana , BREDIKHINA Viktoriia , LEIBA Liudmyla 
Published: March 2023

Ukrainian agriculture remains one of the most problematic sectors of the national economy, and revolutionary processes in rural areas are today in the center of attention of national scientists, politicians, and public representatives. The article carries out a scientific study related to the search for the fundamental reasons for the low effectiveness of reform decisions and actions implemented in Ukraine with the aim of bringing the level of development of Ukrainian rural areas closer to the EU standards. Such research can become the basis for forecasting trends in the development of rural areas of Ukraine in the medium and long term. It can also serve as a reliable basis for applied mechanisms of reforming the agro-industrial complex in the post-war period and the evolution of rural areas of Ukraine in the context of European integration.
It is noted that from the point of view of European integration, there is a natural, labor, technical, technological, scientific and information potential for the development of rural areas of Ukraine. At the same time, there is a need to find alternative approaches to the development of rural areas of Ukraine, in particular, focusing on those principles that ensure effective development of rural areas of EU member states.
Improving the economic security of the country and transitioning to a higher level of socio-economic development is impossible without the creation of a comprehensive, scientifically based strategy for the development of rural areas on the basis of sustainability.
Ecotourism Routes in Ugam-Chatkal State Natural Park and Their Organization
Authors: NARMANOV Ulugbek , NARMANOV Otabek , AZIZAKHAN Mirzaeva 
Published: March 2023

Tourism is one of the most important sectors of the world economy and one of the fastest growing. The tourism industry plays an important role in the economies of many countries.
An analysis of world practice shows that the main features of ecotourism are: an orientation towards organizing a full-fledged recreation in the wild and slightly altered nature, which contributes to the restoration of the physical and spiritual strength of the tourist, expanding his horizons of natural sciences, as well as compliance with ethical standards in the natural and cultural-historical environment. The article was written in connection with the plan of scientific research carried out in order to achieve compliance with the processes of nature management, indicated in the main priorities aimed at ensuring the country's environmental safety.
The Implementation of Community Participation Guidebook Development as an Effort in Environmental Preservation of Air Manis Beach in Padang City
Authors: Aini Wirdatul , Syuraini Syuraini 
Published: March 2023

This article aims to describe the implementation of the development of community participation guidebook in the tourism environmental preservation which includes the testing of validity, practicality, and effectiveness of community participation guidebook in preserving the coastal tourism environment. Quantitative and qualitative research approaches with research and development design. The population of this research were community of coastal tourism, and the samples were food vendors, accessories seller, parking rangers, and tourist which determined purposively. The validity and the practicality tests were obtained from experts in educational, and tourism fields, also from the City Department of Environmental Service, and City Department of Tourism. The data collection technique used are questionnaire for the validity, practicality, and experiment test. Questionnaore were used to gather data on the process of the development of community participation guidebook. The subject of the implementation of the guidebook is the communityin the tourism area, and the experiment is to test the effectiveness of the guidebook. The research findings of the validity test of the content, educational technology, and Indonesian language are very precise, and the practicality result is very good. Test of the effectiveness of the guidebook test is to increase the community participation in preserving the coastal tourism environment. Research findings about the process of preparing guidebook are compiled based on the community beeds, namely behaviors that need to be developed to participate in the preservation of the coastal tourism environment. The contribution of research is to produce the guidebook for community participation in preserving the coastal tourism environment can become a guideline in the development of coastal tourism.
Online Learning Design Digital Guide of Social Media for Teachers
Authors: Siregar Eveline , Aswan Dedy , Kustandi Cecep 
Published: March 2023

Covid-19 pandemic around the world has rapidly changed learning patterns. Students are more interested in social media than online learning. This is reinforced by recent statistics showing increased social media use worldwide during the Covid-19 pandemic. Social media has become an attractive alternative for teachers in online learning activities because ready to use, and many students use it. The use of social media should encourage active, interactive, communicative, creative, and collaborative learning in students because they are used to using it. This research aims to develop a digital guide to help teachers design online learning using social media. This research uses a qualitative approach through the case study to make the model allow the teacher to develop online learning with social media by Combining two models, the ASSURE Model and the Conley and Sabo Model. This research collaborates with high school teachers to conduct focus group discussions. The results of this study illustrate the teacher's view of the digital guidelines developed. Limited ability to use technology is one of the things to consider. This online learning digital guide motivates teachers to continue to innovate amid the covid-19 pandemic. The digital Guidelines guide teachers in online learning to develop online learning in social media, so students feel comfortable studying.
Development of Environmental Awareness Education Model Guidebook in Sekolah Sungai Winongo
Authors: Hiryanto Hiryanto , Wibawa Lutfi , Wijayanto Arif , Tohani Entoh , Rofiq Akhmad 
Published: March 2023

The “sekolah sungai” is an effort to make the community aware of preserving the environment. It is necessary to have a guide book for the implementation of the sekolah sungai Winongo so that it is easily understood by all members of the river school. This study aims to produce a guide book for environmentally conscious education models at the sekolah sungai Winongo. This research is a development research with the ADDIE model, which is carried out until the development stage or model development. Data were collected using interviews, observation and assessment of design and product feasibility. Analysis of the initial condition data was carried out descriptively, the feasibility of the product was carried out by the opinion of the river school material expert, the learning media expert was statistically quantitative using the percentage of success of the model. The results of the study were in the form of a guidebook for the model of environmentally conscious education at the Sekolah Sungai Winongo. The results of expert validation and material validation are in very good criteria and are ready to be tested.
Adsorption of Sr(II) cations onto titanium dioxide, doped with Boron atoms
Authors: Mironyuk Ivan , Vasylyeva Hanna , Prokipchuk Iryna , Mykytyn Igor 
Published: March 2023

The adsorption of Sr(II) cations by Boron-doped TiO2 was investigated. The adsorbent samples were obtained by liquid-phase sol-gel method using the aqua complex precursor [Ті(ОН2)6]3+‧3Cl- and modifying reagent hydrogen borate Н3ВО3. It was found, that single-phase rutile titanium dioxide or two-phase anatase-rutile oxide materials were formed under the different initial ratios of components. Boron atoms are combined with Oxygen atoms into triangular structural cell ВО3 in the rutile sample 0.5В-ТіО2 and are localized in the surface layer of the nanoparticle material as a grouping =О2ВОН. The introduction of Boron atoms into the structure of the rutile adsorbent causes an increase in its adsorption capacity for the binding of Sr(II) cations in the aqueous electrolyte. The maximal adsorption values for Sr(II) cations by the rutile adsorbent in a neutral electrolyte environment reach 102.3 mg‧g-1, while it is equal to 68.8 mg‧g-1 for the unmodified anatase adsorbent a-TiO2.
The number of acid adsorption centers ≡ТіОНδ+ on the surface of the rutile adsorbent 0.5В-ТіО2 is ~ 50 units on a surface area of 10 nm2, which is twice the number of centers on the surface of the anatase adsorbent a- ТіО2. Anatase-rutile adsorbents 1.0В-ТіО2 and 1.5В-ТіО2 contain, respectively, 70% and 57% of the anatase phase. They are significantly inferior in adsorption ability toward cations of Sr(II) compared with the rutile adsorbent 0.5В-ТіО2. This is because Boron atoms are mainly localized in the anatase phase and with oxygen atoms form tetrahedral groups of ВО4-.
The Transport phenomena in CdTe:Cl and CdTe:Cu - calculation from the first principles
Authors: Malyk Orest 
Published: March 2023

In the presented article the method of determining the energy spectrum, the wave function of the charge carrier and the crystal potential in CdTe at an arbitrarily given temperature is considered. Using this approach within the framework of the supercell method the temperature dependences of the ionization energies of various types of defects caused by the introduction of chlorine and copper impurities in cadmium telluride are calculated. Also the offered method allows to define the temperature dependence of the optical and acoustic deformation potentials and as well as the dependence on the temperature the charge carrier’s scattering parameters on ionized impurities, polar optical, piezooptic and piezoacoustic phonons. Within the framework of short-range scattering models the temperature dependences of the charge carrier’s mobility and Hall factor are considered.
До розмірного ефекту в наноструктурних системах
Authors: Vengrenovich R.D. , Ivanskii B.V. , Kryvetskyi V.I. , Fesiv I.V. , Yarema S.V. 
Published: March 2023

Узагальнено формулу Ґiббса–Томсона для нанометрового дiапазону вiд 1 до 10 нм, в якому величина поверхневої енергiї σ0 залежить вiд розмiрiв частинок. Показано, що врахування залежностi σ(r) приводить до змiни розчинностi наночастинок i швидкостi їх росту dr/dt, а вiдтак i до змiни кiнетики всього процесу оствальдiвського дозрiвання. Це особливо важливо у випадку квантових точок, отримуваних методами колоїдної хiмiї, у виглядi сферичних частинок, розмiри яких коливаються вiд одного до декiлькох нанометрiв.