bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auricular Transcutaneous Vagus Nerve Stimulation Specifically Enhances Working Memory Gate Closing Mechanism: A System Neurophysiological Study
Authors: Konjusha Anyla , Yu Shijing , Mückschel Moritz , Colzato Lorenza , Ziemssen Tjalf , Beste Christian 
Published: May 2023

Everyday tasks and goal-directed behavior involve the maintenance and continuous updating of information in working memory (WM). WM gating reflects switches between these two core states. Neurobiological considerations suggest that the catecholaminergic and the GABAergic are likely involved in these dynamics. Both of these neurotransmitter systems likely underlie the effects to auricular transcutaneous vagus nerve stimulation (atVNS). We examine the effects of atVNS on WM gating dynamics and their underlying neurophysiological and neurobiological processes in a randomized crossover study design in healthy humans of both sexes. We show that atVNS specifically modulates WM gate closing and thus specifically modulates neural mechanisms enabling the maintenance of information in WM. WM gate opening processes were not affected. atVNS modulates WM gate closing processes through the modulation of EEG alpha band activity. This was the case for clusters of activity in the EEG signal referring to stimulus information, motor response information, and fractions of information carrying stimulus–response mapping rules during WM gate closing. EEG-beamforming shows that modulations of activity in fronto-polar, orbital, and inferior parietal regions are associated with these effects. The data suggest that these effects are not because of modulations of the catecholaminergic (noradrenaline) system as indicated by lack of modulatory effects in pupil diameter dynamics, in the inter-relation of EEG and pupil diameter dynamics and saliva markers of noradrenaline activity. Considering other findings, it appears that a central effect of atVNS during cognitive processing refers to the stabilization of information in neural circuits, putatively mediated via the GABAergic system.SIGNIFICANCE STATEMENTGoal-directed behavior depends on how well information in short-term memory can be flexibly updated but also on how well it can be shielded from distraction. These two functions were guarded by a working memory gate. We show how an increasingly popular brain stimulation techniques specifically enhances the ability to close the working memory gate to shield information from distraction. We show what physiological and anatomic aspects underlie these effects.
Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
Authors: Kliche Johanna , Garvanska Dimitriya Hristoforova , Simonetti Leandro , Badgujar Dilip , Dobritzsch Doreen , Nilsson Jakob , Davey Norman E , Ivarsson Ylva 
Published: May 2023

AbstractPhosphorylation is a ubiquitous post‐translation modification that regulates protein function by promoting, inhibiting or modulating protein–protein interactions. Hundreds of thousands of phosphosites have been identified but the vast majority have not been functionally characterised and it remains a challenge to decipher phosphorylation events modulating interactions. We generated a phosphomimetic proteomic peptide‐phage display library to screen for phosphosites that modulate short linear motif‐based interactions. The peptidome covers ~13,500 phospho‐serine/threonine sites found in the intrinsically disordered regions of the human proteome. Each phosphosite is represented as wild‐type and phosphomimetic variant. We screened 71 protein domains to identify 248 phosphosites that modulate motif‐mediated interactions. Affinity measurements confirmed the phospho‐modulation of 14 out of 18 tested interactions. We performed a detailed follow‐up on a phospho‐dependent interaction between clathrin and the mitotic spindle protein hepatoma‐upregulated protein (HURP), demonstrating the essentiality of the phospho‐dependency to the mitotic function of HURP. Structural characterisation of the clathrin‐HURP complex elucidated the molecular basis for the phospho‐dependency. Our work showcases the power of phosphomimetic ProP‐PD to discover novel phospho‐modulated interactions required for cellular function.
Pengenalan Ekspresi Mikro Wajah Berdasarkan Point Feature Tracking Menggunakan Fase Apex Pada Database Ekspresi Mikro
Authors: Choirina Priska , Rosiani Ulla Delfana , Fitriani Indah Martha 
Published: May 2023

Ekspresi mikro merupakan ekspresi wajah yang terjadi secara tidak disengaja untuk menyembunyikan perasaan sebenarnya (emotional leakage). Penelitian sebelumnya menggunakan seluruh area wajah dan seluruh frame pada dataset video, hal ini menghasilkan waktu komputasi tergolong lama dan terjadinya redundancy data. Kontribusi utama penelitian ini menerapkan analisa pengenalan ekspresi mikro menggunakan perbandingan frame apex dengan pilihan manual (handcrafted) dan secara acak (random sampling) dan menerapkan pelacakan titik fitur pada area alis mata dan sudut bibir. Discriminative Response Map Fitting (DRMF) sebagai metode yang membentuk titik fitur dan selanjutnya dilakukan pelacakan titik-titik fitur wajah dengan Kanade-Lucas-Tomasi (KLT). Hasil pelacakan titik-titik fitur tersebut menghasilkan data motion features sebagai data ekstraksi fitur dan dilakukan analisa perbandingan metode klasifikasi menggunakan Support Vector Machine (SVM) dan MLP-Backpropagation menggunakan dataset CASME II. Hasil eksperimen penelitian ini menunjukkan hasil yang signifikan dengan akurasi sebesar 81,3% pada MLP-Backpropagation dan waktu komputasi rata-rata 1,45 detik pada setiap video. Hal ini menunjukkan bahwa informasi pada fase apex memberikan informasi yang penting untuk pengenalan ekspresi mikro pada wajah.
Use of plasma rich in growth factors for symptoms of diabetic neuropathy
Authors: Roman S J , Broyer Zach 
Published: May 2023

Summary
Painful peripheral polyneuropathy is a common complication of diabetes mellitus (DM) and is a significant source of chronic disability and remains a challenging condition with no available disease-modifying treatment. In the present case report, we describe the treatment of a patient featuring painful diabetic neuropathy with perineural injections of autologous plasma rich in growth factors (PRGF). At one-year post-procedure, the patient exhibited improved scores on the neuropathic pain scale and improvement in the activity level.

Learning points

Plasma rich in growth factors (PRGF) is an autologous product that can be prepared and administered in a physician’s office.

PRGF can be infiltrated as a liquid, creating a three-dimensional gel scaffold in the body.

PRGF releases growth factors involved in nerve healing.

PRGF may be established as a potent alternative treatment of painful diabetic polyneuropathy.
“It’s easy to just be normal”: Performative masculinities in Die stropers
Authors: Boshoff Danel , Conradie Annemi 
Published: May 2023

In post-apartheid South Africa, the representation of queer identities in Afrikaans-language films have become increasingly prominent. However, many such films focus on past contexts or serve as comedic depictions, failing to confront the complex issues faced by individuals in contemporary Afrikaner communities. Etienne Kallos’s 2018 coming-of-age film Die stropers (The Harvesters) candidly depicts the challenges faced by adoptive brothers Janno and Pieter, who must negotiate desire and gender in a conservative, Afrikaans farming community. Drawing on Judith Butler’s notion of gender performativity and recent reformulations of Raewyn Connell’s notion of hegemonic masculinity, we examine the discursive (re)production of hegemonic Afrikaner masculinity within the boys’ adoptive family and community. We investigate how the protagonists strategically deploy performative masculinities to achieve belonging and acceptance as heirs, even if the ideals they emulate oppress and restrict them. We propose that the protagonists’ strategic deployment of performative masculinities represents their claiming of agency in contexts where gender and desire are aggressively policed. Furthermore, their navigation of hegemony in this white, Afrikaner community through resistance and consent might point to a claiming of space for queer identities and the continued transmutation of hegemonic masculinity.
The Community Stress-Drop Validation Study—Part I: Source, Propagation, and Site Decomposition of Fourier Spectra
Authors: Bindi Dino , Spallarossa Daniele , Picozzi Matteo , Oth Adrien , Morasca Paola , Mayeda Kevin 
Published: May 2023

AbstractAs part of the community stress-drop validation study initiative, we apply a spectral decomposition approach to isolate the source spectra of 556 events occurred during the 2019 Ridgecrest sequence (Southern California). We perform multiple decompositions by introducing alternative choices for some processing and model assumptions, namely: three different S-wave window durations (i.e., 5 s, 20 s, and variable between 5 and 20 s); two attenuation models that account differently for depth dependencies; and two different site amplification constraints applied to restore uniqueness of the solution. Seismic moment and corner frequency are estimated for the Brune and Boatwright source models, and an extensive archive including source spectra, site amplifications, attenuation models, and tables with source parameters is disseminated as the main product of the present study. We also compare different approaches to measure the precision of the parameters expressed in terms of 95% confidence intervals (CIs). The CIs estimated from the asymptotic standard errors and from Monte Carlo resampling of the residual distribution show an almost one-to-one correspondence; the approach based on model selection by setting a threshold for misfit chosen with an F-ratio test is conservative compared to the approach based on the asymptotic standard errors. The uncertainty analysis is completed in the companion article in which the outcomes from this work are used to compare epistemic uncertainty with precision of the source parameters.
A PERSPECTIVA BLOCKCHAIN NAS COMPRAS GOVERNAMENTAIS
Authors: De oliveira Joao Alex 
Published: May 2023

A tecnologia que serve de base para os criptoativos (ou criptomoedas) é considerada uma das principais tendências para a transformação digital. Disruptiva por essência, a tecnologia blockchain (ou cadeia de blocos) pode contribuir para promover otimização em vários contextos da atuação humana. O presente trabalho tem por finalidade mapear o processo de compras compartilhadas de TIC do Instituto Federal Sul de Minas e apresentar abordagens possíveis para otimização. A partir de concepções baseadas na arquitetura blockchain foram exploradas abordagens possíveis de correção aos problemas de fluxo identificados, observando aspectos de desburocratização e de desintermediação, sem deixar de assegurar a integridade, a auditabilidade e a rastreabilidade que devem ser inerentes às licitações públicas. Os resultados, embora sejam conclusivos para o escopo do estudo, são intermediários por se tratarem de uma proposta a ser implementada: diagramas obtidos a partir do mapeamento do processo que permitiram abstrair (visualmente) suas etapas; e proposta de abordagem que representa como poderia ser a realização do processo implementado em uma plataforma blockchain.
Clinical Significance of Serum Biomarkers: Vascular Endothelial Growth Factor-A and Chemokine (C-X-C motif) Ligand 13 in Egyptian Multiple Myeloma Patients
Authors: Kassem Neemat M , Saadeldin Ibtessam , Zawam Hussam , Kassem Hebatallah A 
Published: May 2023

Multiple myeloma (MM) is a human B-cell neoplasia arising from malignant plasma cells. Vascular endothelial growth factor (VEGF) is among growth factors essential for angiogenesis in MM. However, chemokine (C-X-C motif) ligand 13 (CXCL13) allows the chemotaxis of mature B cells expressing its receptor CXCR5.CXCL13-CXCR5 interactions are involved in MM progression. This study aimed at investigating 2 serum biomarkers; VEGF-A and CXCL13 levels using enzyme linked immunosorbent assays (ELISA) in 48 Egyptian myeloma patients as well as correlation with different clinic-pathological features, survival and therapy response. VEGF-A and CXCL13 levels were significantly higher in MM cases in comparison to control group (P=0.04* and 0.01*, respectively). An indirect proportional relation between VEGF-A and CXCL13 levels in myeloma patients was found (r= -0.27, P=0.22). Alb/creat ratio change showed indirect proportional relation with VEGF-A (r= -0.446, P=0.043*). Patients obtained complete remission (CR)had insignificantly lower VEGF-A and higher CXCL13 levels compared to other patients, P=0.2 and 0.7, respectively. In conclusion, production of variety of growth factors and cytokines such as VEGF-A and CXCL13 was higher in MM patients. However, our experiment has to be done on larger sample size and extended period of follow up to validate the participation of the VEGF-A and CXCL13 in disease progression and clinical outcome.
Drug-Related Poisonings among Chilean Adult Population
Authors: Schulz-Bañares Berta , González-Norambuena Carla , Müller-Ramírez Claudio 
Published: May 2023

Background: Poisonings is a preventable public health problem that globally affects the population. We aimed to characterize drug-related acute poisonings occurred in Chile between the years of 2016 and 2020.
Methods: A retrospective study of poisonings among hospitalized patients was carried out. Data were obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients admitted into either public or private healthcare settings with diagnosis of drug-related poisoning according to the WHO ICD-10 codes T30-T50. Statistical analyses were run to establish either significant associations or differences between variables selected in the study.
Results: Overall, 12,975 poisonings were identified during the 2016-2020 period. These events corresponded to 0.16% of all national hospital admissions in the study period. Women represented 71.1% of the cases. 76.7% of events were related to intentional poisonings while 7.3% and 16% were accidental and undetermined poisonings respectively. 44.6% of accidental and intentional poisonings occurred at the age of 18-29 yr old. Benzodiazepines (22.8%), antidepressants (11.2%), and acetaminophen (5.1) were the most common drugs associated with poisonings. Average length of hospitalization was between 3.3 and 8.2 days. 0.6% of poisonings resulted in deaths.
Conclusion: Poisonings were characterized by patients’ sex and age, circumstance of exposure, length of hospitalization, and outcome. Poisoning rates were stable along the years with a slight decrease in 2020. Intentional poisonings among young women and men were more common. Most of the cases had favorable outcome for patients.
Borzuya, The physician: A curriculum output of Khosravani Education
Authors: M Aghabagheri , M Mehrmohammadi , Kh Bagheri Noaparast 
Published: May 2023

Introduction: Borzuya, the physician, a sage as well, is one of the prominent figures of Shahnameh in Sassanid era especially in Nushirvan court. In seeking of the immortality tree, he made a voyage to India. Such a burden to bear for memorization and its translation to Pahlavi and then dedication the work made him immortal owing to the allocation of the first chapter as Borzuya, the sage.
Methods: Regarding a method fusion of history, analysis, and education, the germane sources were reflected upon and some presuppositions were critically pondered as the similarity of Borzuya and Bozorgmehr. However, these names are two distinguished figures in Shahnameh, a physician and a minister, respectively. Regarding, the concept of development is not allocated to one facet, but it is multifaceted. Also it must be noted that the true outreach won’t come but with comprehensive and true thinking, design, edit, execution and assessment.
Results: First, the education of Ancient Persia is categorized as an educational archetype due to interaction of Iranian civilization with its east and west civilizations. Second, the educational implications of Shahnameh can be represented in different levels; basic (art and wisdom education) and supreme (intuition and immortality education).
Conclusion: One of the principles of education including medical education is allocated to the role model presentation for the students. Owing to the personality of Bozuya who was a famous physician and furthermore he was an expert in philosophy, linguistics, literature, and logic, he can be presented as an appropriate role model for any contemporary learner.
La Gestión de las Artes Visuales: Artistas-etc., Gestiones Autónomas, Profesionalización y Trabajo en la Ciudad de Córdoba
Authors: PETRONI ILZE GABRIELA , MARTÍN PEREYRA LUCAS 
Published: May 2023

Esta ponencia introduce algunas consideraciones de índole teórica sobre la investigación titulada Prácticas artísticas, profesionalización y trabajo: el caso de las gestiones autónomas de la ciudad de Córdoba (2015-2019). Es así que, en esta oportunidad, nos centramos en esclarecer brevemente las distinciones en torno a las categorías de trabajo, labor, empleo, actividad y desempleo; para luego describir –también sucintamente– las problemáticas que dificultan la precisión en el análisis del sector artístico-visual por parte de la administración pública (en sus diferentes niveles) junto con la incidencia de la educación artística en la formación profesional de su comunidad de estudiantes. En un cuarto momento nos detendremos a considerar algunas de las problemáticas de los espacios/iniciativas autónomas, los límites de la noción de “autonomía” y su vinculación con las prácticas artísticas.
Palabras clave: gestión autónoma, artista-etc., trabajo, profesionalización, arte visual
Peranan Komisi Pengawas Persaingan Usaha dalam Kegiatan yang Dilarang dalam Wujud Predatory Pricing Sektor E-Commerce
Authors: Jonathan Julius 
Published: May 2023

Abstract
In globalization, modernization has occurred all aspects including economic field with emergence of e-commerce platforms to facilitate trade. In e-commerce sector, there is practice of flash sales are suspected form of predatory pricing. In addition, business competition in e-commerce sector must be supervised by KPPU because it has opportunity for unfair business competition to occur easily and technical aspects of business competition are different from conventional. The purpose of preparing this article to analyze alleged practice of flash sales as predatory pricing and analyze role of KPPU in supervising business competition in e-commerce sector. The research methodology uses normative juridical methods. The results, practice of flash sales cannot be stated directly as form of predatory pricing so that it uses a rule of reason approach and KPPU's role in supervising business competition in e-commerce must supported by adjustments to statutory regulations and KPPU can supervise business competition in e-commerce sector.
Keywords: e-commerce; unfair business competition; predatory pricing; KPPU

Abstrak
Pada era globalisasi, terjadi modernisasi pada seluruh aspek kehidupan manusia termasuk pada bidang ekonomi dengan timbul platform e-commerce untuk mempermudah perdagangan. Pada bidang e-commerce, terdapat praktik flash sale dan diduga merupakan bentuk predatory pricing. Selain itu, persaingan usaha pada sektor e-commerce harus diawasi oleh KPPU karena berpeluang terjadinya persaingan usaha tidak sehat dengan mudah dan teknis persaingan usaha memiliki perbedaan dari konvensional. Oleh karena itu, tujuan penyusunan artikel ini adalah menganalisa dugaan praktik flash sale sebagai predatory pricing terhadap ketentuan Undang-undang Nomor 5 tahun 1999 dan menganalisa terkait peran KPPU dalam mengawasi persaingan usaha di sektor ecommerce. Metodologi penelitian menggunakan metode yuridis normatif. Hasil dari penelitian ini adalah praktik flash sale tidak dapat dinyatakan secara langsung merupakan bentuk predatory pricing sehingga menggunakan pendekatan rule of reason dan peran KPPU dalam mengawasi persaingan usaha pada e-commerce harus didukung penyesuaian regulasi peraturan perundang-undangan sehingga KPPU dapat mengawasi persaingan usaha pada sektor e-commerce.
Kata Kunci: e-commerce; persaingan usaha tidak sehat; predatory pricing; flash sale; KPPU
Analysis of Marketing Strategy in Achieving Banking Goals at PT Bank Xyz
Authors: Mustajab Duta 
Published: May 2023

This study aims to determine the marketing strategy that has run the company and to determine the relationship marketing strategy through SWOT analysis carried out by the company in relation to the achievement of corporate goals.
While the methods of analysis used in this study is an analysis of SWOT analysis is to mngetahui strengths and weaknesses and the opportunities and threats faced by the Bank in the implementation of marketing strategies.
Based on the results of the study showed that based on the evaluation of the implementation of the marketing strategy implementation SWOT banking services , especially in the company of PT. Bank Mandiri Branch Makassar, which indicates that the marketing strategies undertaken so far in the marketing of banking services has been able to minimize weaknesses and threats in implementing strategies that have been carried out and in addition the power and opportunities are more prominent when compared to the weaknesses and threats. Based on the results of the SWOT analysis , the strategy is suitable for use in the marketing of banking services at PT. Bank Mandiri Branch Makassar is an aggressive strategy.
The Power of Digital Tools Leveraged for Excellence in Operation Planning
Authors: Gupta N. , Moraes W. Oda de Oliveira , Vieira C. , Khelil R. 
Published: May 2023

Abstract
The oil and gas (O&G) business is going through a natural but accelerated evolution to incorporate more digital tools into its business model. While it is important to adapt quickly, under such circumstances it is equally important to plan with the future in mind. The biggest challenge the oil and gas industry has faced recently is the sudden shifts in demand and supply. The pandemic era curbed demand, while the recovery resulted in an unprecedented supply shortage. This imbalance identified an opportunity to quickly evolve new sales and operational planning (S&OP) processes. These processes were designed to continually balance supply and demand at different time horizons. The digital capabilities were further empowered to harness S&OP potential to forecast and plan better than ever before. The digital planning tool (DPT) is now part of the business fabric, enabling product forecasting up to 12 months out. This paper illustrates one of the steps in the technological digital journey driven by O&G service companies. It shows how implementing a DPT enables S&OP processes to optimize resource management. Such optimization creates a more agile and accurate response to a fluctuating demand-supply balance, improving company performance overall.