bluuebunny/crossref_metadata_2025_split huggingface dataset:
Роль стратегічного лідерства у розвитку стратегії кадрової політики
Authors: Holota Olena , Tytkovskyi Oleksandr 
Published: May 2023

Мета роботи: Мета цієї статті полягає в тому, щоб дослідити, які атрибути стратегічного лідера, такі як якості, здібності та поведінка, мають значення для розробки та реалізації стратегії управління військовими людськими ресурсами в процесі оборонного планування на основі спроможностей. Вивчення представленого алгоритму стратегії може запропонувати військовим лідерам новий погляд на ефективне застосування своїх характеристик у діяльності з управління людськими ресурсами.
Методи: під час роботи використані теоретичний, системний та функціональний методи дослідження.
Результати дослідження: під час дослідження було встановлено, що стратегічне лідерство відіграє ключову роль у процесі розробки стратегії управління людськими ресурсами з основними якостями, здібностями та поведінкою стратегічного лідера. У цьому сенсі здатність стратегічних лідерів формулювати, створювати, координувати та реалізовувати стратегію як послідовну комбінацію кінцевої мети, стратегічних цілей, послідовних дій і ресурсів для їх досягнення (взаємопов’язане поєднання цілей, способів і засобів) має пріоритетне значення для інституційного будівництва оборони.
Практична цінність дослідження: огляд наявної літератури мало доказів вивчення можливого алгоритму розробки стратегії управління персоналом у зв’язку зі специфікою стратегічних лідерів. У цій статті кожен із визначених етапів стратегії представлений разом із відповідними атрибутами та дає читачам можливість осмислити їх практичне застосування.
Тип статті: практична.
Finanças pessoais: a influência das disciplinas de finanças no comportamento financeiro dos estudantes de administração de uma universidade pública
Authors: Silva Valdilene Gonçalves Machado , Pereira Amanda Ferreira , Barros Nivea Mara de Faria , Vieira Maria Augusta de Assis 
Published: May 2023

Este estudo teve como finalidade analisar se as disciplinas de finanças estudadas durante o curso de Administração de uma Universidade Pública do centro-oeste mineiro, influenciavam o comportamento financeiro dos estudantes. Assim, foi realizada uma pesquisa descritiva, com abordagem qualitativa e quantitativa, utilizando-se o estudo de caso. Observou-se que os estudantes que participaram da pesquisa eram, majoritariamente, do gênero feminino, solteiros, haviam ingressado no mercado de trabalho, tinham entre dezenove e vinte e quatro anos e uma renda mensal entre R$1.101,00 a R$2.950,00. Os resultados indicaram que o conteúdo de Finanças Pessoais não fazia parte das ementas das disciplinas de Finanças oferecidas pelo curso. Porém, o tema era tratado através das atividades complementares desenvolvidas nas disciplinas. Assim, pode-se verificar que a hipótese levantada de que as disciplinas de finanças contribuíam para os estudantes terem um comportamento financeiro mais consciente foi validada.
Análise da qualidade de vida de pacientes submetidas ao tratamento cirúrgico de câncer de mama
Authors: Souza Juliana Ribeiro da Silva , Silva Beatriz Arrais , Vizzoto Júnior Alvo Orlando , Lopes Guilherme Munhoz , Silva Nancy Christiane Ferreira , Francisco Ícaro da Costa , Torresan Clarissa 
Published: May 2023

O câncer de mama, patologia decorrente da soma de fatores genéticos e epigenéticos e causa de imensos efeitos negativos para a paciente em todo o seu contexto de vida, representa o segundo tumor mais incidente nas mulheres do Brasil. Existem diversas formas terapêuticas para o carcinoma de mama como a radioterapia, quimioterapia, hormonioterapia e o tratamento oncológico cirúrgico, dentre os quais há a mastectomia total e a cirurgia conservadora de mama, indicados de acordo com o tipo de câncer e seu estadiamento. É necessário ressaltar que essas cirurgias podem gerar complicações como necrose cutânea, infecções, hematomas e linfedemas de braços, além de afetar psicologicamente as pacientes. O presente estudo, quantitativo, descritivo e exploratório de corte transversal, objetiva comparar os impactos na qualidade de vida de mulheres submetidas ao tratamento cirúrgico do câncer de mama, através do questionário BREAST-Q, para que se possa analisar os impactos das duas técnicas cirúrgicas no grupo de pacientes entrevistadas. A partir do estudo foi possível demonstrar a diferença entre as influências dos dois cenários de tratamento cirúrgico na qualidade de vida das pacientes, evidenciando que a mastectomia tem impacto negativo mais expressivo que a cirurgia conservadora de mama em todos os aspectos abordados. Conclui-se a necessidade do desenvolvimento de estratégias para o restabelecimento da qualidade de vida dessas mulheres.
Intraoperative hemodynamic optimization using the hypotension prediction index vs. goal-directed hemodynamic therapy during elective major abdominal surgery: the Predict-H multicenter randomized controlled trial
Authors: Lorente Juan V. , Ripollés-Melchor Javier , Jiménez Ignacio , Becerra Alejandra I. , Mojarro Irene , Fernández-Valdes-Bango Paula , Fuentes Maria A. , Moreno Ana , Agudelo Maria E. , Villar-Pellit de la Vega Angel , Ruiz-Escobar Alicia , Cortés Azahara , Venturoli Rocio , Quintero Ana , Acedo Guadalupe M. , Abad-Motos Ane , Gómez Peña , Abad-Gurumeta Alfredo , Monge-García Manuel I. 
Published: May 2023

BackgroundIntraoperative hypotension (IOH) is associated with increased morbidity and mortality after major abdominal surgery but remains significant even when using goal-directed hemodynamic therapy (GDHT) protocols. The Hypotension Prediction Index (HPI) is a machine learning-derived parameter that predicts arterial hypotension. We tested the hypothesis that an HPI-based protocol reduces the duration and severity of hypotension compared with a GDHT protocol during major abdominal surgery.MethodsThis is a parallel-arm double-blinded multicenter randomized trial involving adult patients undergoing elective major abdominal surgery at five centers. Patients were optimized according to a previously recommended GDHT protocol (GDHT group) or the HPI value (HPI group). Hemodynamic optimization in both groups started 15 min after the surgical incision. The primary outcome was the intraoperative time-weighted average of mean arterial pressure under 65 mmHg (TWA-MAP &lt; 65 mmHg). Other metrics for IOH and secondary outcomes, including TWA below individual baseline values of intraoperative tissue oxygenation (StO2), postoperative AKIRisk, postoperative complications, length of stay, and 30-day mortality, were explored.ResultsEighty patients were randomized (40 patients in each group). TWA-MAP &lt; 65 mmHg was 0.06 (25th–75th interquartile range: 0–0.27) mmHg in the GDTH group vs. 0 (0–0.04) mmHg in the HPI group (p = 0.015). Total time with MAP &lt; 65 mmHg per patient was 4.6 (0–21) min in the GDHT group and 0 (0–3) min in the HPI group (p = 0.008). The TWA below the baseline StO2 was 0.40% (0.12%–2.41%) in the GDHT group and 0.95% (0.15%–3.20%) in the HPI group (p = 0.353). The AKIRisk values obtained in the GDHT group were 0.30 (0.14–0.53) and 0.34 (0.15–0.67) in the GDHT and HPI groups (p = 0.731), respectively. Both groups had similar postoperative complications, length of stay, and 30-day mortality.ConclusionsAn HPI-based protocol reduced intraoperative hypotension compared with a standard GDHT protocol, with no differences in tissue oxygenation and postoperative AKIRisk.
U-shaped association of serum uric acid with all-cause mortality in patients with hyperlipidemia in the United States: a cohort study
Authors: Huang Lihua , Lu Zhanpeng , You Xiaoyan , Zou Chunsheng , He Liuliu , Xie Jingxiang , Zhou Xiaoqing 
Published: May 2023

BackgroundSerum uric acid (SUA) interferes with lipid metabolism and is considered an independent risk factor for atherosclerosis, a major complication in patients with hyperlipidemia. However, the effects of uric acid levels on mortality in hyperlipidemic patients has yet to be sufficiently determined. In this study, we aimed to assess the association between all-cause mortality and SUA in a hyperlipidemic population.MethodsTo determine mortality rates, we obtained data for 20,038 hyperlipidemia patients from the U.S. National Health and Nutrition Examination Surveys (NHANES) 2001–2018 and National Death Index. To examine the all-cause mortality effect of SUA, multivariable Cox regression models, restricted cubic spline models, and two pairwise Cox regression models were used.ResultsOver a median follow-up of 9.4 years, a total of 2079 deaths occurred. Mortality was examined according to SUA level quintiles: &lt;4.2, 4.3–4.9, 5.0–5.7, 5.8–6.5, and &gt;6.6 mg/dl. In multivariable analysis using 5.8–6.5 mg/dl SUA as a reference, the hazard ratios (95% confidence interval) of all-cause mortality across the five groups were 1.24 (1.06–1.45), 1.19 (1.03–1.38), 1.07 (0.94–1.23), 1.00 (reference), and 1.29 (1.13–1.48), respectively. According to a restricted cubic spline, we noted a U-shaped relationship between SUA and all-cause mortality. The inflection point was approximately 6.30 mg/dl, with hazard ratios of 0.91 (0.85–0.97) and 1.22 (1.10–1.35) to the left and right of the inflection point, respectively. In both sexes, SUA was characterized by a U-shaped association, with inflection points at 6.5 and 6.0 mg/dl for males and females, respectively.ConclusionUsing nationally representative NHANES data, we identified a U-shaped association between SUA and all-cause mortality in participants with hyperlipidemia.
Sodium-glucose cotransporter-2 inhibitors use and the risk of gout: a systematic review and meta-analysis
Authors: Lai Shih-Wei , Hwang Bing-Fang , Kuo Yu-Hung , Liu Chiu-Shong , Liao Kuan-Fu 
Published: May 2023

ObjectiveTo assess the relationship between use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and the risk of gout among patients with type 2 diabetes mellitus (T2DM).MethodsA systemic review and meta-analysis were designed by reviewing articles published between 2000 January 1 and 2022 December 31 using PubMed system and Web of Science system based on the PRISMA 2020 guidelines. The end point of interest was gout (including gout flares, gout events, starting uric-acid lowering therapy and starting anti-gout drugs use) among patients with T2DM using SGLT2i versus not using SGLT2i. A random-effects model was utilized to measure the pooled hazard ratio (HR) with 95% confidence interval (CI) for the risk of gout associated with SGLT2i use.ResultsTwo prospective post-hoc analyses of randomized controlled trials and 5 retrospective electronic medical record-linkage cohort studies met the inclusion criteria. The meta-analysis demonstrated that there was a decreased risk of developing gout for SGLT2i use as comparing with non-use of SGLT2i among patients with T2DM (pooled HR=0.66 and 95%CI=0.57-0.76).ConclusionsThis meta-analysis demonstrates that SGLT2i use is associated with a 34% decreased risk of developing gout among patients with T2DM. SGLT2i may be the treatment options for patients with T2DM who are at high risk of gout. More randomized controlled trials and real-world data are needed to confirm whether there is a class effect of SGLT2i for the risk reduction of gout among patients with T2DM.
Flash heating boosts the potential for mechanochemical energy sources for subglacial ecosystems
Authors: Stone Jordan , Edgar John O. , Rutherford Johnny , Gill-Olivas Beatriz , Tranter Martyn , Gould Jamie A. , Xavier Cijo M. , Telling Jon 
Published: May 2023

Subglacial environments harbour a diversity of microbial ecosystems capable of influencing biogeochemical cycles. However, the darkness and isolation of subglacial environments limit the energy sources available for microbial metabolism. A recently recognised energy source for these microbes in wet-based regions is the rock-water reactions that occur after the mechanical fracturing of glacial bedrock. These mechanochemical reactions produce H2 and H2O2 at 0°C from reactions with mineral surface defects (Si• and SiO•) and release Fe from within the mineral structures, providing electron donors and acceptors for microbial metabolism. However, the production of H2O2 and H2 may be underestimated as temperatures at rock abrasion sites can increase substantially above 0°C as glaciers “slip and grind” rocks, potentially accelerating the rates of mechanochemical reactions. Despite this, the effect of rapid heating on subsequent low-temperature mechanochemical reactions has yet to be examined. Here, we investigate H2, H2O2, and Fe production during low-temperature (0 °C) incubations of water with a range of ground rocks and minerals following “flash heating” to 30, 60, or 121 °C. We show that transient increases (as little as 5–10 min of heating) to moderate temperatures (30 or 60 °C) can significantly increase the rate of H2 production, while short-term heating to 121 °C generates larger bursts of H2. In addition, pyrite is easily crushed, potentially releasing large quantities of Fe2+ into subglacial systems and promoting mechanochemical reactions due to the resulting large surface area (10× larger than other materials). We provide the first evidence for H2 production from water reactions with crushed pyrite and suggest that crushed pyrite has a greater influence on subglacial H2O2 production than silicates. We conclude that electron donors in the form of Fe2+ and H2 bursts can be produced in subglacial ecosystems, which may be coupled to substantial concentrations of H2O2 produced from crushed pyrite. This suggests that rock–water mechanochemical reactions may be a greater source of energy for subglacial environments than previously recognised.
Risk prediction model construction for post myocardial infarction heart failure by blood immune B cells
Authors: Sun HouRong , Kong XiangJin , Wei KaiMing , Hao Jie , Xi Yue , Meng LingWei , Li GuanNan , Lv Xin , Zou Xin , Gu XingHua 
Published: May 2023

BackgroundMyocardial infarction (MI) is a common cardiac condition with a high incidence of morbidity and mortality. Despite extensive medical treatment for MI, the development and outcomes of post-MI heart failure (HF) continue to be major factors contributing to poor post-MI prognosis. Currently, there are few predictors of post-MI heart failure.MethodsIn this study, we re-examined single-cell RNA sequencing and bulk RNA sequencing datasets derived from the peripheral blood samples of patients with myocardial infarction, including patients who developed heart failure and those who did not develop heart failure after myocardial infarction. Using marker genes of the relevant cell subtypes, a signature was generated and validated using relevant bulk datasets and human blood samples.ResultsWe identified a subtype of immune-activated B cells that distinguished post-MI HF patients from non-HF patients. Polymerase chain reaction was used to confirm these findings in independent cohorts. By combining the specific marker genes of B cell subtypes, we developed a prediction model of 13 markers that can predict the risk of HF in patients after myocardial infarction, providing new ideas and tools for clinical diagnosis and treatment.ConclusionSub-cluster B cells may play a significant role in post-MI HF. We found that the STING1, HSPB1, CCL5, ACTN1, and ITGB2 genes in patients with post-MI HF showed the same trend of increase as those without post-MI HF.
Exhaustion of CD8+ central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients
Authors: Leonhard Jonas , Schaier Matthias , Kälble Florian , Zeier Martin , Steinborn Andrea 
Published: May 2023

IntroductionImmunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR).MethodsIn this study, we separately investigated the differentiation of CD8+ regulatory T cells (Tregs) and responder T cells (Tresps) between healthy KTR without NMSC, KTR developing de-novo NMSC within two years after the enrolment, and KTR with NMSC at the time of enrolment. Antigen-unexperienced CCR7+CD45RA+CD31+ recent thymic emigrant (RTE) cells differentiate via CD45RA-CD31+ memory (CD31+ memory) cells, via resting mature naïve (MN) cells or via direct proliferation into CD45RA-CD31- memory (CD31- memory) cells, consisting of both CCR7+CD45RA- central memory (CM) and CCR7-CD45RA- effector memory (EM) cells.ResultsWe found that both RTE Treg and Tresp differentiation via CD31+ memory Tregs/Tresps was age-independently increased in KTR, who developed de novo NMSC during the follow-up period, causing abundant CM Treg/Tresp production, which may be crucial for cancer immunity. These changes favored a strongly increased CD8+ Treg/Tresp ratio, suggesting this ratio as a reliable marker for de-novo NMSC development in KTR. However, with age, this differentiation was replaced by increased conversion of resting MN Tregs/Tresps into CM Tregs/Tresps, which exhausted for Tresps but not for Tregs. In KTR with already existing NMSC at enrolment, differentiation was maintained via conversion and proliferation of resting MN Tregs/Tresps, which however increasingly exhausted with age, especially for Tresps. This resulted in a strong accumulation of terminally differentiated effector memory (TEMRA) Tresps in elderly individuals. Patients with NMSC recurrence showed increased proliferation of resting MN Tregs/Tresps into EM Tregs/Tresps, which tended to exhaust more rapidly, particularly for Tresps, than in patients without NMSC recurrence.DiscussionIn conclusion, we provide evidence that immunosuppressive therapy inhibits differentiation of CD8+ Tregs more than that of CD8+ Tresps, resulting in an exhausted Tresp profile, thus providing a possible therapeutic approach to improve poor cancer immunity in elderly KTR.
Successful treatment of a refractory intestinal Behcet’s disease with an oncology history by Vedolizumab: a case report and literature review
Authors: Li Ruixia , Li Xiaofei , Zhou He , Shi Yanting , Wang Fang , Wu Tong , Liang Jie 
Published: May 2023

ObjectiveBehçet’s Disease (BD) is an intractable systemic vasculitis. When accompanied by intestinal symptoms, the prognosis is usually poor. 5-Aminosalicylic acid (5-ASA), corticosteroids, immunosuppressive drugs, and anti-tumor necrosis factor-α (anti-TNF-α) biologics are standard therapies to induce or maintain remission for intestinal BD. However, they might not be effective in refractory cases. Safety should also be considered when patients have an oncology history. Regarding the pathogenesis of intestinal BD and the specific targeting effect of vedolizumab (VDZ) on the inflammation of the ileum tract, previous case reports suggested that VDZ might be a potential treatment for refractory intestinal BD.MethodsWe report a 50-year-old woman patient with intestinal BD who had oral and genital ulcers, joint pain, and intestinal involvement for about 20 years. The patient responds well to anti-TNF-α biologics but not to conventional drugs. However, biologics treatment was discontinued due to the occurrence of colon cancer.ResultsVDZ was intravenously administered at a dose of 300 mg at 0, 2, and 6 weeks and then every eight weeks. At the 6-month follow-up, the patient reported significant improvement in abdominal pain and arthralgia. We observed complete healing of intestinal mucosal ulcers under endoscopy. However, her oral and vulvar ulcers remained unresolved, which disappeared after adding thalidomide.ConclusionVDZ may be a safe and effective option for refractory intestinal BD patients who do not respond well to conventional treatments, especially those with an oncology history.
Overall survival comparison between pediatric and adult Ewing sarcoma of bone and adult nomogram construction: a large population-based analysis
Authors: Hsu Chi-Jen , Ma Yongguang , Xiao Peilun , Hsu Chia-Chien , Wang Dawei , Fok Mei Na , Peng Rong , Xu Xianghe , Lu Huading 
Published: May 2023

BackgroundEwing sarcoma (ES) is a common primary bone tumor in children. Our study aimed to compare overall survival (OS) between pediatric and adult bone ES patients, identify independent prognostic factors and develop a nomogram for predicting OS in adult patients with ES of bone.MethodsWe retrospectively analyzed data for the 2004–2015 period from the Surveillance, Epidemiology, and End Results (SEER) database. To guarantee well-balanced characteristics between the comparison groups, propensity score matching (PSM) was used. Kaplan–Meier (KM) curves were used to compare OS between pediatric and adult patients with ES of bone. Univariate and multivariate Cox regression analyses were used to screen independent prognostic factors for ES of bone, and a prognostic nomogram was constructed by using the factors identified. The prediction accuracy and clinical benefit were evaluated using receiver operating characteristic (ROC) curves, areas under the curves (AUCs), calibration curves, and decision curve analysis (DCA).ResultsOur results showed that adult ES patients had lower OS than younger ES patients. Age, surgery, chemotherapy, and TNM stage were independent risk factors for bone ES in adults and were used to develop a nomogram. AUCs for 3-, 5-, and 10-year OS were 76.4 (67.5, 85.3), 77.3 (68.6, 85.9) and 76.6 (68.6, 84.5), respectively. Calibration curves and DCA results indicated excellent performance for our nomogram.ConclusionWe found that ES pediatric patients have better OS than adult ES patients, and we constructed a practical nomogram to predict the 3-, 5- and 10-year OS of adult patients with ES of bone based on independent prognostic factors (age, surgery, chemotherapy, T stage, N stage and M stage).
Morphologic classification of tracheobronchial arborization in children with congenital tracheobronchial stenosis and the associated cardiovascular defects
Authors: Hu Jie , Wang Hao , Du Xinwei , Zhu Limin , Wang Shunmin , Zhang Haibo , Xu Zhiwei , Chen Hao 
Published: May 2023

BackgroundWe sought to classify patients with congenital tracheal stenosis (CTS) according to tracheobronchial morphology and determine anatomic features associated with tracheobronchial anomalies (TBAs) and concurrent cardiovascular defects (CVDs).MethodsWe enrolled 254 patients who underwent tracheoplasty between November 1, 2009 and December 30, 2018. The anatomic features of the tracheobronchial tree and cardiovascular system were abstracted from bronchoscopy, echocardiography, computerized tomography, and operative reports.ResultsFour types of tracheobronchial morphology were identified: Type-1, which included normal tracheobronchial arborization (Type-1A, n = 29) and tracheal bronchus (Type-1B, n = 22); Type-2 (tracheal trifurcation; n = 49), and Type-3 (typical bridging bronchus; n = 47). Type-4 (bronchus with an untypical bridging pattern) was divided into Type-4A (involving bronchial diverticulum; n = 52) and Type-4B (absent bronchus; n = 55). Carinal compression and tracheomalacia were significantly more frequent in Type-4 patients than in the other patients (P &lt; 0.01). CVDs were common in patients with CTS, especially in patients with Type-3 and Type-4 (P &lt; 0.01). Persistent left superior vena cava was most common among patients with Type-3 (P &lt; 0.01), and pulmonary artery sling was most frequent among those with Type-4 (P &lt; 0.01). Outflow tract defects were most likely to occur in Type-1B. Early mortality was detected in 12.2% of all patients, and young age (P = 0.02), operation in the early era (P &lt; 0.01), and bronchial stenosis (P = 0.03) were proven to be risk factors.ConclusionsWe demonstrated a useful morphological classification for CTS. Bridging bronchus was most closely linked with vascular anomalies, while tracheal bronchus was frequently associated with outflow tract defects. These results may provide a clue to CTS pathogenesis.