bluuebunny/crossref_metadata_2025_split huggingface dataset:
II. Kapitel: Zur Frage nach Kontinuität und Diskontinuität – Unzuverlässiges Erzählen vor der Nachkriegsliteratur
Authors: Aumüller Matthias 
Published: July 2023

ZusammenfassungKaum eine historische Zäsur ist so schmal an Jahren und reicht so tief wie die Zeit des Nationalsozialismus. Es gibt Gründe für die Annahme, dass mit ihrem Ende – nachdem nicht nur Europa durch militärische Aktionen weitgehend in Schutt und Asche gelegt worden war, sondern auch ganze Bevölkerungsgruppen zu großen Teilen einer industriell betriebenen Ausrottung zum Opfer gefallen waren – etwas Neues begann, nicht nur im politischen, sondern auch im literarischen Leben. Das sahen nicht zuletzt die Repräsentanten der Nachkriegsliteratur selbst so.
V. Kapitel: Unzuverlässiges Erzählen nach Max Frisch
Authors: Aumüller Matthias 
Published: July 2023

ZusammenfassungUnzweifelhaft haben Max Frisch und Friedrich Dürrenmatt der Literatur der Schweiz nach 1945 zu internationalem Ansehen verholfen. Ihre besondere Stellung innerhalb der Schweiz verdankt sich nicht zuletzt ihrer kritischen Haltung gegenüber in der Schweiz weithin anerkannten politischen und gesellschaftlichen Gepflogenheiten. Die nächste Autorengeneration, die nicht nur in der Schweiz, sondern überall aufmüpfiger war, konnte daran anknüpfen.
IX. Kapitel: Eine falsche Theorie – Alfred Anderschs Efraim (1967)
Authors: Aumüller Matthias 
Published: July 2023

ZusammenfassungAlfred Andersch ist eine der Schlüsselfiguren der westdeutschen Nachkriegsliteratur. Seine Bedeutung für die Literatur und das literarische Leben gründet auf mehreren Faktoren. Chronologisch gesehen, steht seine Tätigkeit als Herausgeber der politisch-literarischen Zeitschrift Der Ruf in Zusammenarbeit mit Hans Werner Richter am Anfang seiner Karriere.
The empirical modelling of house prices and debt revisited: a policy-oriented perspective
Authors: Boug Pål , Hungnes Håvard , Kurita Takamitsu 
Published: July 2023

AbstractThe recent boom in house prices in many countries during the COVID-19 pandemic and the possibility of household financial distress are of concern among some central banks. We revisit the empirical modelling of house prices and household debt with a policy-oriented perspective using Norwegian data over the last four decades within the cointegrated VAR model. Our findings suggest, in line with previous work, a long-run mutually reinforcing relationship between these financial magnitudes, and thus the potential for the build-up of financial instabilities and spillover effects to the real economy. Applying a policy control analysis, we find that both house prices and debt are controllable magnitudes to some pre-specified target levels through the mortgage interest rate, which enables the central bank to reduce large fluctuations and bubble tendencies in the housing market. The present control analysis thus provides some useful policy implications from empirically relevant representations of two important financial factors entering the decision process of the policy maker.
Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors
Authors: Gergs Ulrich , Jacob Hannes , Braekow Pauline , Hofmann Britt , Pockes Steffen , Humphrys Laura J. , Kirchhefer Uwe , Fehse Charlotte , Neumann Joachim 
Published: July 2023

AbstractLysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice with cardiomyocyte-specific overexpression of the human 5-HT4 receptor (5-HT4-TG) or of the H2-histamine receptor (H2-TG). For comparison, we used wild type littermate mice (WT). Finally, we measured isometric force of contraction in isolated electrically stimulated muscle strips from the human right atrium obtained from patients during bypass surgery. LSD (up to 10 µM) concentration dependently increased force of contraction and beating rate in left or right atrial preparations from 5-HT4-TG (n = 6, p < 0.05) in 5-HT4-TG atrial preparations. The inotropic and chronotropic effects of LSD were antagonized by 10 µM tropisetron in 5-HT4-TG. In contrast, LSD (10 µM) increased force of contraction and beating rate in left or right atrial preparations, from H2-TG. After pre-stimulation with cilostamide (1 µM), LSD (10 µM) increased force of contraction in human atrial preparations (n = 6, p < 0.05). The contractile effects of LSD in human atrial preparations could be antagonized by 10 µM cimetidine and 1 µM GR 125487. LSD leads to H2-histamine receptor and 5-HT4-receptor mediated cardiac effects in humans.
Is PSMA PET/CT cost-effective for the primary staging in prostate cancer? First results for European countries and the USA based on the proPSMA trial
Authors: Holzgreve Adrien , Unterrainer Marcus , Calais Jérémie , Adams Thaiza , Oprea-Lager Daniela E. , Goffin Karolien , Lopci Egesta , Unterrainer Lena M. , Kramer Kristina K. M. , Schmidt-Hegemann Nina-Sophie , Casuscelli Jozefina , Stief Christian G. , Ricke Jens , Bartenstein Peter , Kunz Wolfgang G. , Mehrens Dirk 
Published: July 2023

Abstract
Purpose
The proPSMA trial at ten Australian centers demonstrated increased sensitivity and specificity for PSMA PET/CT compared to conventional imaging regarding metastatic status in primary high-risk prostate cancer patients. A cost-effectiveness analysis showed benefits of PSMA PET/CT over conventional imaging for the Australian setting. However, comparable data for other countries are lacking. Therefore, we aimed to verify the cost-effectiveness of PSMA PET/CT in several European countries as well as the USA.

Methods
Clinical data on diagnostic accuracy were derived from the proPSMA trial. Costs for PSMA PET/CT and conventional imaging were taken from reimbursements of national health systems and individual billing information of selected centers in Belgium, Germany, Italy, the Netherlands, and the USA. For comparability, scan duration and the decision tree of the analysis were adopted from the Australian cost-effectiveness study.

Results
In contrast to the Australian setting, PSMA PET/CT was primarily associated with increased costs in the studied centers in Europe and the USA. Mainly, the scan duration had an impact on the cost-effectiveness. However, costs for an accurate diagnosis using PSMA PET/CT seemed reasonably low compared to the potential consequential costs of an inaccurate diagnosis.

Conclusion
We assume that the use of PSMA PET/CT is appropriate from a health economic perspective, but this will need to be verified by a prospective evaluation of patients at initial diagnosis.
Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
Authors: Blain Maxime , Narayanan Govindarajan , Ricoeur Alexis , Kobe Adrian , Mahendra Ashwin M. , Jacks Blake , Letty Quentin , Bonnet Baptiste , Tselikas Lambros , Deschamps Frederic , de Baère Thierry 
Published: July 2023

Abstract
Introduction
The safety and efficacy of a microwave ablation (MWA) system for the liver with novel technologies in field control, antenna cooling through the inner part of the choke ring, and dual temperature monitoring were evaluated in this multicenter retrospective study.

Material and Methods
Ablation characteristics and efficacy were assessed on follow-up imaging (computed tomography or magnetic resonance imaging). Safety was evaluated according to CTCAE classification.

Results
Eighty-seven liver tumors (65 metastases and 22 hepatocellular carcinomas) measuring 17.8 ± 7.9 mm were treated in 68 patients. Ablation zones measured 35.6 ± 11 mm in longest diameter. The coefficients of variation of the longest and shortest ablation diameters were 30.1% and 26.4%, respectively. The mean sphericity index of the ablation zone was 0.78 ± 0.14. Seventy-one ablations (82%) had a sphericity index above 0.66. At 1 month, all tumors demonstrated complete ablation with margins of 0–5 mm, 5–10 mm, and greater than 10 mm achieved in 22%, 46%, and 31% of tumors, respectively. After a median follow-up of 10 months, local tumor control was achieved in 84.7% of treated tumors after a single ablation and in 86% after one patient received a second ablation. One grade 3 complication (stress ulcer) occurred, but was unrelated to the procedure. Ablation zone size and geometry in this clinical study were in accordance with previously reported in vivo preclinical findings.

Conclusion
Promising results were reported for this MWA device. The high spherical index, reproducibility, and predictability of the resulting treatment zones translated to a high percentage of adequate safety margins, providing good local control rate.
Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia
Authors: Shome Durjoy , Al-Jamea Lamiaa , Woodman Alexander , Salem Abdel Halim , Bakhiet Moiz , Taha Safa , Sandhu Amarjit Kaur , Al-Yami Fatimah S. , Waheed Khawaja Bilal , Elnagi Elmoeiz Ali , Almish Mohammed , Quiambao Jenifer Vecina 
Published: July 2023

Abstract
Purpose
This is the first study that aimed to determine antigen levels in plasma and genotypes of PAI-2 in pregnant and non-pregnant homozygous sickle cell anemia (SCA) patients.

Methods
The study subjects were all Bahraini females in the reproductive age group. The study population included 31 pregnant homozygous SS (SCA) patients. Three control groups were also studied to evaluate the effect of pregnancy and SCA on PAI-2 levels and fibrinolysis: (1) 31 healthy non-pregnant volunteers; (2) 31 cases of normal pregnancy; and (3) 20 non-pregnant SCA patients. Pregnancies were screened in the second (TM2) and third (TM3) trimesters. Global coagulation, fibrinolysis rate (euglobulin clot lysis time, ECLT), PAI-2 antigen (ELISA), and PAI-2 Ser(413)/Cys polymorphism (restriction fragment length polymorphism analysis) were determined.

Results
Feto-maternal complications were documented in both pregnancy groups. PAI-2 antigen levels were undetectable in the non-pregnant groups, but was quantifiable in both pregnant groups. Impaired fibrinolysis rate and rising PAI-2 levels with progression of pregnancy were observed in both healthy and SCA subjects. These changes were more prominent in SCA, although the rise in ECLT was less steep and PAI-2 antigen levels were not significantly different compared to normal pregnancy in the third trimester. No correlation was observed between PAI-2 genotypes and plasma antigen levels. Also, no significant difference in feto-maternal complications was found in normal (n = 25) versus SCA pregnant patients (n = 30).

Conclusions
These observations suggest that with progression of pregnancy, increasing PAI-2 levels contribute to the hypercoagulable state, particularly in SCA patients.
Prediction of Age Older than 18 Years in Sub-adults by MRI Segmentation of 1st and 2nd Molars
Authors: Bjørk Mai Britt , Kvaal Sigrid Ingeborg , Bleka Øyvind , Sakinis Tomas , Tuvnes Frode Alexander , Haugland Mari-Ann , Eggesbø Heidi Beate , Lauritzen Peter Mæhre 
Published: July 2023

Abstract
Purpose
To investigate prediction of age older than 18 years in sub-adults using tooth tissue volumes from MRI segmentation of the entire 1st and 2nd molars, and to establish a model for combining information from two different molars.

Materials and methods
We acquired T2 weighted MRIs of 99 volunteers with a 1.5-T scanner. Segmentation was performed using SliceOmatic (Tomovision©). Linear regression was used to analyse the association between mathematical transformation outcomes of tissue volumes, age, and sex. Performance of different outcomes and tooth combinations were assessed based on the p-value of the age variable, common, or separate for each sex, depending on the selected model. The predictive probability of being older than 18 years was obtained by a Bayesian approach using information from the 1st and 2nd molars both separately and combined.

Results
1st molars from 87 participants, and 2nd molars from 93 participants were included. The age range was 14-24 years with a median age of 18 years. The transformation outcome (high signal soft tissue + low signal soft tissue)/total had the strongest statistical association with age for the lower right 1st (p= 7.1*10-4 for males) and 2nd molar (p=9.44×10-7 for males and p=7.4×10-10 for females). Combining the lower right 1st and 2nd molar in males did not increase the prediction performance compared to using the best tooth alone.

Conclusion
MRI segmentation of the lower right 1st and 2nd molar might prove useful in the prediction of age older than 18 years in sub-adults. We provided a statistical framework to combine the information from two molars.
OME-Zarr: a cloud-optimized bioimaging file format with international community support
Authors: Moore Josh , Basurto-Lozada Daniela , Besson Sébastien , Bogovic John , Bragantini Jordão , Brown Eva M. , Burel Jean-Marie , Casas Moreno Xavier , de Medeiros Gustavo , Diel Erin E. , Gault David , Ghosh Satrajit S. , Gold Ilan , Halchenko Yaroslav O. , Hartley Matthew , Horsfall Dave , Keller Mark S. , Kittisopikul Mark , Kovacs Gabor , Küpcü Yoldaş Aybüke , Kyoda Koji , le Tournoulx de la Villegeorges Albane , Li Tong , Liberali Prisca , Lindner Dominik , Linkert Melissa , Lüthi Joel , Maitin-Shepard Jeremy , Manz Trevor , Marconato Luca , McCormick Matthew , Lange Merlin , Mohamed Khaled , Moore William , Norlin Nils , Ouyang Wei , Özdemir Bugra , Palla Giovanni , Pape Constantin , Pelkmans Lucas , Pietzsch Tobias , Preibisch Stephan , Prete Martin , Rzepka Norman , Samee Sameeul , Schaub Nicholas , Sidky Hythem , Solak Ahmet Can , Stirling David R. , Striebel Jonathan , Tischer Christian , Toloudis Daniel , Virshup Isaac , Walczysko Petr , Watson Alan M. , Weisbart Erin , Wong Frances , Yamauchi Kevin A. , Bayraktar Omer , Cimini Beth A. , Gehlenborg Nils , Haniffa Muzlifah , Hotaling Nathan , Onami Shuichi , Royer Loic A. , Saalfeld Stephan , Stegle Oliver , Theis Fabian J. , Swedlow Jason R. 
Published: July 2023

AbstractA growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals and institutes across diverse modalities facing these problems have designed a format specification process (OME-NGFF) to address these needs. This paper brings together a wide range of those community members to describe the cloud-optimized format itself—OME-Zarr—along with tools and data resources available today to increase FAIR access and remove barriers in the scientific process. The current momentum offers an opportunity to unify a key component of the bioimaging domain—the file format that underlies so many personal, institutional, and global data management and analysis tasks.
Branchioma with a nested/organoid morphology: molecular profiling of a distinctive potentially misleading variant and reappraisal of potential relationship to CD34-positive/Rb1-deficient tumors of the neck
Authors: Baněčková Martina , Michal Michael , Vaněček Tomáš , Grossman Petr , Nikolov Dimitar Hadži , Včelák Radek , Žalud Radim , Michal Michal , Agaimy Abbas 
Published: July 2023

AbstractBranchioma (previously called ectopic hamartomatous thymoma, branchial anlage mixed tumor, or thymic anlage tumor) is a rare lower neck lesion with an adult male predominance and an uncertain histogenesis. Except for 4 cases, all branchiomas described in the literature were benign. Recently, HRAS mutation was detected in one case, but still little is known about the molecular genetic background of this rare entity. We herein report the histological, immunohistochemical, and molecular genetic analysis of a branchioma with a nested/organoid (neuroendocrine-like) morphology in a 78-year-old man. Histology revealed classical branchioma areas merging with nested/organoid cellular component lacking conventional features of malignancy. Immunohistochemistry was positive for high-molecular-weight cytokeratins. CD34 was expressed in the spindle cell component. Moreover, the tumor cells showed near-complete loss of retinoblastoma (RB1) expression (<1% of cells positive). All neuroendocrine markers (synaptophysin, chromogranin, and INSM1) were negative. Next-generation sequencing (TSO500 Panel) revealed 5 pathogenic/likely pathogenic mutations including 1 mutation in KRAS and 2 different mutations in each of MSH6 and PTEN. FISH and DNA sequencing were negative for RB1 gene alterations. To our knowledge, this is the first report of a branchioma showing misleading nested/organoid morphology and the first report on Rb1 immunodeficiency in this entity, in addition to multiple gene mutations revealed by NGS.
Iterated Medial Triangle Subdivision in Surfaces of Constant Curvature
Authors: Brunck Florestan 
Published: July 2023

AbstractConsider a geodesic triangle on a surface of constant curvature and subdivide it recursively into four triangles by joining the midpoints of its edges. We show the existence of a uniform $$\delta >0$$

δ
>
0

such that, at any step of the subdivision, all the triangle angles lie in the interval $$(\delta ,\pi -\delta )$$

(
δ
,
π
-
δ
)

. Additionally, we exhibit stabilising behaviours for both angles and lengths as this subdivision progresses.
A hybrid artificial intelligence solution approach to aftercare for cancer patients
Authors: Scherrer Alexander , Zimmermann Tobias , Riedel Sinan , Venios Stefanos , Koussouris Sotiris , Plakia Maria , Diamantopoulos Sotiris , Athanassopoulos Sotiris , Laras Paris , Mousa Fihmi , Zifrid Robert , Tillil Hartmut , Musisi Isa Wasswa , Kosmidis Thanos , Reis Joaquim C. , Moehler Markus , Oestreicher Gabrielle , Kalamaras Ilias , Pantelidou Konstantina , Votis Konstantinos , Vassiliou Charalampos 
Published: July 2023

AbstractThis publication presents a solution approach to oncological aftercare for cancer patients by means of artificial intelligence (AI) methods. This approach shall support patients in overcoming the after-effects of therapy effectively with suitable supportive actions and health-care professionals in goal-oriented planning of these actions. Different AI methods are used for analyzing patients’ needs for supportive actions depending on the available health data and for a monitoring of these actions. Decision support methods are used for effective planning of actions based on the AI results of analysis. The solution approach is realized in the form of a web application for health-care professionals, which allows for data analysis and planning of actions, and a mobile application for patients, which facilitates documentation and monitoring of supportive actions. In combination, they facilitate a closed-loop workflow for the effective cooperation of health-care professionals and cancer patients. The solution approach is illustrated for an exemplary case scenario of colorectal cancer.
A dimensionality reduction approach for convolutional neural networks
Authors: Meneghetti Laura , Demo Nicola , Rozza Gianluigi 
Published: July 2023

AbstractThe focus of this work is on the application of classical Model Order Reduction techniques, such as Active Subspaces and Proper Orthogonal Decomposition, to Deep Neural Networks. We propose a generic methodology to reduce the number of layers in a pre-trained network by combining the aforementioned techniques for dimensionality reduction with input-output mappings, such as Polynomial Chaos Expansion and Feedforward Neural Networks. The motivation behind compressing the architecture of an existing Convolutional Neural Network arises from its usage in embedded systems with specific storage constraints. The conducted numerical tests demonstrate that the resulting reduced networks can achieve a level of accuracy comparable to the original Convolutional Neural Network being examined, while also saving memory allocation. Our primary emphasis lies in the field of image recognition, where we tested our methodology using VGG-16 and ResNet-110 architectures against three different datasets: CIFAR-10, CIFAR-100, and a custom dataset.
A Numerical Study on Premixed Turbulent Planar Ammonia/Air and Ammonia/Hydrogen/Air Flames: An Analysis on Flame Displacement Speed and Burning Velocity
Authors: Tamadonfar Parsa , Karimkashi Shervin , Kaario Ossi , Vuorinen Ville 
Published: July 2023

AbstractThe economic storage and transportation of ammonia ($$\hbox {NH}_3$$

NH
3

), and its capability to be thermally decomposed to hydrogen ($$\hbox {H}_2$$

H
2

) make it a potential carbon-free synthetic fuel for the future. To comprehend the fundamental characteristics of $$\hbox {NH}_3$$

NH
3

as a primary fuel enriched with $$\hbox {H}_2$$

H
2

under low turbulent premixed flame conditions, three quasi direct numerical simulations (quasi-DNS) with detailed chemistry and the mixture-averaged transport model are conducted under decaying turbulence herein. The Karlovitz number is fixed to 4.28 for all the test conditions. The blending ratio ($$\alpha$$
α
), specifying the hydrogen concentration in the ammonia/hydrogen mixture, varies from 0.0 to 0.6. The results reveal that the mean value of the density-weighted flame displacement speed ($$S_{\textrm{d}}^{*}$$

S

d

∗

) is similar to (higher than) the unstrained premixed laminar burning velocity ($$S_{\textrm{L}}^{0}$$

S

L

0

) for $$\hbox {NH}_3/$$

NH
3

/

air flame ($$\hbox {NH}_3/\hbox {H}_2/$$

NH
3

/

H
2

/

air flames). Furthermore, the performance of two extrapolation relations for estimating $$S_{\textrm{d}}^{*}$$

S

d

∗

as linear and non-linear functions of flame front curvature is discussed thoroughly. The performances of both models are almost similar when evaluating the data near the leading edge of the flame. However, the non-linear one offers more accurate results near the trailing edge of the flame. The results show that the mean flame stretch factor increases with increasing the blending ratio, suggesting that the mean flamelet consumption velocity deviates from $$S_{\textrm{L}}^{0}$$

S

L

0

by enriching the mixture with $$\hbox {H}_2$$

H
2

. The mean value of the local equivalence ratio ($$\phi$$
ϕ
) for the turbulent $$\hbox {NH}_3/$$

NH
3

/

air flame is almost equal to its laminar counterpart, while it deviates significantly for $$\hbox {NH}_3/\hbox {H}_2/$$

NH
3

/

H
2

/

air flames. In addition, the local equivalence ratio for the flame front with positive curvature values is higher than the negatively curved regions for $$\hbox {NH}_3/\hbox {H}_2/$$

NH
3

/

H
2

/

air flames due to $$\hbox {H}_2$$

H
2

preferential diffusion. Furthermore, the results indicate that hydrogen is consumed faster in positively curved regions compared to the negatively curved zones due to enhanced reaction rates of specific chemical reactions.
Physicalism Without the Idols of Mathematics
Authors: Szabó László E. 
Published: July 2023

AbstractI will argue that the ontological doctrine of physicalism inevitably entails the denial that there is anything conceptual in logic and mathematics. The elements of a formal system, even if they are tagged by suggestive names, are merely meaningless parts of a physically existing machinery, which have nothing to do with concepts, because they have nothing to do with the actual things. The only situation in which they can become meaning-carriers is when they are involved in a physical theory. But in this role they refer to elements of the physical reality, i.e. they represent a physical concept. “Mathematical concepts” are just idols, that philosophy can completely deny and physics can completely ignore.