bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD19/CD22 dual-targeting Chimeric antigen receptor T cell therapy bridging to allogeneic hematopoietic stem cell transplantation for B-cell acute lymphoblastic leukemia delays platelet recovery and increases risks of cytomegalovirus and Epstein-Barr Virus viremia after transplantation
Authors: Wu Depei , Li Shijia , Ge Jianrong , Zhou Shiyuan , Zhu Wenjuan , Han Yue , Chen Suning , Xue Sheng-Li Xue Sheng-Li , Wang Ying , Qiu Huiying , Wu Xiaojin 
Published: April 2023

Abstract
Integration of chimeric antigen receptor T (CAR-T) cell therapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an emerging technology for B-cell acute lymphoblastic leukemia (B-ALL) treatment with unknown impact on HSCT-related complications. We performed a retrospective cohort study of patients receiving CD19/CD22 dual-targeting or CD19 single-targeting CAR-T therapy before HSCT (CD19/CD22 dual-targeting CAR-T group and CD19 single targeting CAR-T group, respectively), and patients did not receive CAR-T therapy before transplantation (non-CAR-T group). Cumulative incidence of platelet engraftment on day 28 was lower in the CD19/CD22 dual-targeting CAR-T group compared to other groups (p=0.028) and it was proved to be an independent risk factor for delayed platelet recovery on day 28 (OR: 2.65; p=0.001). The CD19/CD22 dual-targeting CAR-T bridging to HSCT independently increases risk of early CMV-viremia (HR, 2.96; p=0.001). Both CAR-T groups had higher incidence of 100-day Epstein-Barr virus (EBV)-viremia, compared with the non-CAR-T group (p=0.043 and p=0.001, respectively). Patients receiving CAR-T cell therapy had a higher risk for early EBV-viremia (HR, 6.77; p=0.030). Relapse and survival did not differ between the 3 groups (p>0.05). Integrating CD19/CD22 dual-targeting CAR-T therapy and HSCT delays platelet engraftment and increases the risks of early CMV- and EBV-viremia.
Relationship between perceived stress and online flaming among adolescents: Mediating roles of fear of missing out and ego depletion
Authors: Yin Zijun , Xuan Bin 
Published: April 2023

Abstract
This study aimed to examine the direct relationship between perceived stress and online flaming, as well as the mediating roles of fear of missing out and ego depletion. A sample of Chinese junior and senior high school students (N = 556) was included. Students completed the Perceived Stress Scale, Fear of Missing out Scale, Ego Depletion Scale, and the Online Flaming Scale.
The results indicated that tension (perceived stress sub-dimension) had a direct effect on online flaming, and perceived stress and loss of control (perceived stress sub-dimension) did not have a direct effect on online flaming. Moreover, perceived stress and tension (perceived stress sub-dimension) had an indirect effect on online flaming through the mediating roles of fear of missing out and ego depletion, and loss of control (perceived stress sub-dimension) did not have an indirect effect on online flaming through the mediating roles of fear of missing out and ego depletion. These findings enhanced the understanding of the mechanism of online flaming and provided new perspectives for the prevention of online flaming among adolescents.
Drug-Drug Interaction Extraction Using Transformer-based Ensemble Model
Authors: Sefidgarhoseini Sarina , Safari Leila , Mohammady Zanyar 
Published: April 2023

Abstract
Purpose Drug-drug interactions (DDIs), or the simultaneous use of several medications, can impair the effectiveness of the medications, have negative physiological consequences, raise the price of medical treatment, or even endanger the health and lives of patients. In order to increase patient safety when using drugs, it is crucial to do research in the area of automated extraction of DDIs. It benefits the medical industry and forms a foundation for DDI databases to be updated automatically.Methods This article's goal is to suggest a useful classification and identification scheme for DDIs. Based on a range of characteristics, including text, POS tags, distance, and SDP features, three deep learning-based models are presented: CNN, BiLSTM, and BiLSTM with attention. Three models based on transformers are also proposed: BERT, RoBERTa, and ELECTRA. In addition, an approach using an ensemble of transformer-based models is suggested for extracting DDIs from medical literature.Results All models were applied to the benchmark DDIExtraction2013 dataset. The results showed that the attention mechanism in deep learning models is very effective and has led to comparable results with the best existing models, but other features are not helpful. Also, with a 12% improvement in the F-measure score, the ensemble method showed indisputably supremacy over the existing methods and other proposed methods in this study.Conclusion Transformer-based models with the bidirectional processing ability and internal attention mechanism outperform deep learning models.
Integrated trajectories optimization for Jupiter missions with single-satellite-aided capture
Authors: Li Mingtao , Jing Quan 
Published: April 2023

Abstract
In Jupiter missions, single-satellite-aided capture employs the gravity assist of one of the Galilean moons, which could decrease the required Δv to capture a spacecraft into the nominal orbit around Jupiter. Previous studies on single-satellite-aided capture mainly focused on Jovicentric orbits. In this paper, an optimization that focuses on Jovicentric orbits and considers the planetary segment and the nominal orbit around Jupiter was proposed. We use Jupiter arriving excess velocity and arriving time as the link between these two segments, which clearly illustrates single-satellite-aided capturing. VEGA and VEEGA sequences (both planetary gravity assist sequences) are tested in the numerical simulation. The result, with the complete orbits of the mission, indicates the reliability and good convergence of the method. It also turns out that Io and Ganymede are the first options for satellite-aided capture.
Elucidation of The Potential Mechanism of Guanxin Ⅱ Formula Against Traumatic Brain Injury, Depression and Functional Dyspepsia Through Network Pharmacology Strategy
Authors: Cai Yawen , Zhou Li , Chen Li , Zhang Xiaohang , Ren Ping , Huang Xi 
Published: April 2023

Abstract
With the aging of the world population trend intensifying, a growing number of individuals are suffering from two or more long-term diseases, namely multimorbidity. Traditional Chinese Medicine (TCM) medication is a unique treatment method in China. Traditional Chinese medicine formulae (FTCM) contain multiple herbs with multi-target, multichannel, and multi-link characteristics. Besides, FTCM is known for its multi-targeted pharmacological function and fewer side effects. Guanxin Ⅱ is a representative compound with powerful pharmacological effects, such as cardio-protection, anti-traumatic brain injury (TBI), anti-depression, and anti-functional dyspepsia (FD). Moreover, its mechanism is mainly through inhibiting the inflammatory response. However, due to the complex biological active ingredients of the herbal formula, its active ingredients and mechanism of action in the treatment of TBI, depression, and FD are not yet fully elucidated. Therefore, we first explored the main active ingredients and potential mechanisms of action of Guanxin Ⅱ in the treatment of TBI, depression, and FD by using network pharmacology methods. Nextly, principal component analysis (PCA) was used to validate the relationship between Guanxin Ⅱ and three commonly used drugs for these diseases. Subsequently, we docked the principal components (luteolin, quercetin, and β-sitosterol) with key targets (IL-6, IL-1β, and TNF) of Guanxin Ⅱ in the treatment of TBI, depression, and FD, by molecular docking methods, which further validated the above analysis results. In conclusion, Guanxin Ⅱ has therapeutic effects on TBI, depression, and FD, mainly by inhibiting the secretion of inflammatory cytokines from reducing the inflammatory response.
Assessment of safety and in situ antibacterial activity of Weissella cibaria strains isolated from Campos das Vertentes, Minas Gerais, Brazil for their food application
Authors: Teixeira Camila Gonçalves , Belguesmia Yanath , Rodrigues Rafaela Silva , Lucau-Danila Anca , Nero Luís Augusto , Carvalho Antônio Fernandes , Drider Djamel 
Published: April 2023

Abstract
Aims: Weissella cibaria W21, W25 and W42 strains have previously been characterized for their antagonism against a range of foodborne pathogens. However, prior to their use as protective agents, further analyses such as their safety and in situactivity are needed.
Methods and Results: The safety of W. cibaria W21, W25 and W42 strains was predicted in silico and confirmed experimentally. Analyses of their genomes using appropriate software did not reveal any acquired antimicrobial resistance genes, nor mobile genetic elements (MGE). The survival of each strain was determined in vitro under conditions mimicking the gastrointestinal tract (GIT). Thus, hemolysis, cytotoxicity and the inflammation capabilities of these strains were respectively determined on blood agar, using a mixture of two cell-lines composed of 50% Caco-2/HT-29 and on the promonocytic human cell line U937. The Weissellastrains were found to be haemolysis-negative, non-cytotoxic and did not induce any inflammation. Furthermore, these strains adhered tightly to intestinal Caco-2 cell-lines and exerted in situ anti-proliferative activity against methicillin resistant Staphylococcus aureus (strain MRSA S1) and Escherichia coli 181, a colistin resistant strain. However, the W. cibariastrains showed low survival rate under simulated GIT conditions in vitro.
Conclusion: The unusual LAB-strains Weissella cibaria strains W21, W25 and W42 are safe and endowed with potent antibacterial activities. These strains are therefore good candidates for industrial applications.
Significance and Impact of Study: The results of this study allow a better characterization and to gain insights into Weissella strains, which are considered as unusual LAB, but which prompt a growing interest in their bio-functional properties and their potential industrial applications.
An overview of approaches for reducing uncertainties in hydrological forecasting: progress, and challenges
Authors: Panchanathan Anandharuban , Ahrari Amir Hossein , Ghag Kedar , Must Syed Md Touhidul , Haghighi Ali Torabi , Kløve Bjørn , Oussalah Mourad 
Published: April 2023

Abstract

In the present study, we review the methods and approaches used for uncertainty handling in hydrological forecasting of streamflow, floods, and snow. This review has six thematic sections: (1) general trends in accounting uncertainties in hydrological forecasting, (2) sources of uncertainties in hydrological forecasting, (3) methods used in the studies to address uncertainty, (4) multi-criteria approach for reducing uncertainty in hydrological forecasting and its applications (5) role of remote sensing data sources for hydrological forecasting and uncertainty handling, (6) selection of hydrological models for hydrological forecasting. Especially, a synthesis of the literature showed that approaches such as multi-data usage, multi-model development, multi-objective functions, and pre-/post-processing are widely used in recent studies to improve forecasting capabilities. This study reviews the current state-of-the-art and explores the constraints and advantages of using these approaches to reduce uncertainty. The comparative summary provided in this study offers insights into various methods of uncertainty reduction, highlighting the associated advantages and challenges for readers, scientists, hydrological modelers, and practitioners in improving the forecast task. A set of freely accessible remotely sensed data and tools useful for uncertainty handling and hydrological forecasting are reviewed and pointed out.
Experimental study on the effect of attapulgite powder addition amount on lubricating performance of lubricant
Authors: WANG Jie , YANG Hongjuan , WANG Shisong , FENG Huiling , DENG Xingqiao 
Published: April 2023

Abstract
Attapulgite rod clay (ATP) powder has been widely studied as a high-quality lubricant additive, but its anti-wear and antifriction mechanism has not been clearly explained. To solve this problem, oil samples with different attapulgite powder contents were prepared in this study, and friction and wear tests were carried out to test the friction coefficient on the surface of the friction pair. Finally, X-ray photoelectron spectroscopy was used to verify the analysis results, and the mechanism of anti-wear and friction reduction of attapulgite powder was revealed fundamentally. The research results show that the reason why the lubricating performance of the oil sample is closely related to the amount of attapulgite powder is the proportion of Al2O3 and Fe2O3 in the friction layer, indicating that the lubricating performance of the oil sample is positively correlated with the proportion of Al2O3 and Fe2O3 in the friction layer.
Optimal BG Regulation in Type-I Diabetes Mellitus (TIDM) Patient using Adaptive Control Algorithm
Authors: Patra Akshaya Kumar , Panigrahi Girija Sankar 
Published: April 2023

Abstract
This article describes the design of Teaching Learning Based Optimization Algorithm -Tilt Integral-Derivative-Filter (TLBOA-TIDF) controller to infuse ideal insulin doses to manage Blood Glucose (BG) levels in TIDM patients with an Artificial Pancreas (AP). In this control technique, Teaching Learning Based Optimization Algorithm (TLBOA) is used, that adjusts the controller gains of the proposed patient model for better regulation of BG. This classic TLBOA controller is designed to improve patient performance and robustness. Nonlinearities present in the patient model pose problems for glycemic control. Using an AP-based TLBOA efficiently overcomes the nonlinearity of patient models and maintains BG levels in the glycemic band (70–120 mg/dl). Use of the suggested patient model with TLBOA-TIDF is examined for precision, consistency, robustness, noise reduction and improved ability to handle uncertainty. A comparative study of results from different control methods reveals the causes of the advanced control performance of the proposed approach.
Unique pharmacokinetics for oral tacrolimus administration following allogeneic hematopoietic stem cell transplantation for AML with Shwachman–Diamond syndrome
Authors: ionue yasuyuki , uemura yu , kosugi shigeki , kanno masatoshi , sano fumiaki 
Published: April 2023

Abstract
Shwachman–Diamond syndrome(SDS) is a rare autosomal recessive multisystem diseasecharacterized by exocrine pancreatic insufficiency, impaired hematopoiesis, and a predisposition to leukemia [1]. We previously reported successful haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in adult patients with acute myeloid leukemia (AML) and SDS [2]. Herein, we describe the unique pharmacokinetics of orally administered tacrolimus in one such patient.
Indicatioon of vegetation site conditions of the park «Sosnovka» using Ramensky’s ecological scales
Authors: Ле К.Ву. , Нешатаев В.Ю. 
Published: April 2023

В 2021 г. в парке Сосновка выполнены геоботанические описания на тех же участках, где в 1925-1926 гг. Я.Я. Васильев и А.Г. Гаель определили доминанты живого напочвенного покрова, полноту, возраст и бонитет насаждений. В 1925- 1926 гг. в Сосновке преобладали сосняки брусничные и черничные. За 96-97 лет часть сосняков сменилась березняками. В составе древостоев появились липа сердцевидная, клёны платановидный и татарский, рябина обыкновенная, в подросте исчезла сосна, но появилось много широколиственных деревьев, сформировался ярус подлеска из 17 видов. В травяно-кустарничковом ярусе сократилось обилие черники и брусники, других лесных видов, появились виды луговые, сорно-рудеральные, сорно-пасквальные, сорно-судубравные (сныть, гравилат городской и др.). Произошло сильное сокращение проективного покрытия зелёных лесных мхов и их частичная замена на Climacium dendroides, Sanionia uncinata, Plagiomnium cuspidatum, представителей семейства Brachytheciaceae. Исчезли сосняки лишайниковые. Индикация условий увлажнения с помощью шкал Л.Г. Раменского и др. (1956) показала, что оно осталось практически неизменным (66-71 в 1925-1926 г. и 65-73 в 2022 г.). Индикация условий богатства-засоления почв с помощью шкал показала, что почвенное плодородие возросло примерно на одну ступень (3,6-4,1 в 1925- 1926 г. и 4,0-5,0 в 2022 г.).
In 2021, geobotanical descriptions were carried out in Sosnovka Park on the same sites where in 1925-1926 Y.Y. Vasiliev and A.G. Gael determined the dominants of the living ground cover, completeness, age and bonitet of plantings. In 1925-1926, lingonberry and blueberry pine forests prevailed in Sosnovka. Over 96-97 years, the vegetation and soils of Sosnovka Park have undergone significant changes. Some of the pine forests were replaced by birch forests. The small-leaved lime, Norway and Tatar maples, common rowan appeared in the stands. There is no pine among young generation, but there are many young broad-leaved trees. To date, a well-defined layer of undergrowth appeared, consisting of 17 species of shrubs and small trees. In the grass-shrub layer, the abundance of blueberries and cranberries, other forest specieshas decreased, meadow species, weed-ruderal, weed-pascal, weed-subnemoral occurred. There was a strong reduction in the projective coverage of green forest mosses and their partial replacement by Climacium dendroides, Sanionia uncinata, Plagiomnium cuspidatum, representatives of the Brachytheciaceae family. Lichen pine forests have completely disappeared in Sosnovka. Indication of moisture conditions using L.G.Ramensky scales (1956) showed that it remained unchanged (66-71 in 1925-26 and 65-73 in 2022). Indication of soil richness-salinity conditions using L.G.Ramensky scales (1956) showed that soil fertility increased by approximately 1 step (3.6-4.1 in 1925-26 and 4.0-5.0 in 2022).
Development of a personalized diet using the structural optimization method
Authors: Lisitsyn A. B. , Chernukha I. M. , Nikitina M. А. 
Published: April 2023

The design of a human personalized diet considering a variety of different factors is associated with system analysis and formalization of data and knowledge, as well as with the development of digital technologies. The paper presents the methodology of optimization and formation of personalized diets based on structural-parametric modeling. The proposed approach allows solving the following tasks: 1) to analyze the daily diet or individual meals (breakfast, lunch, afternoon snack, dinner, additional meals or snacks) with a known quantitative set of finished products in terms of energy value and chemical composition in order to reveal dietary disorders; 2) to calculate quantity of products optimal for a meal from the fixed list, thereby composing an individual reference diet with regard to the mental and physical activities, nutritive status of a consumer and economic aspects; 3) to optimize a diet depending on the task at hand by selecting a group of finished products from a complete or selected list of archival data, equally taking into account all the necessary parameters; 4) to adjust the diet taking into account dietary deviations in certain parameters of the chemical composition and energy value by additional introduction of special purpose products with the increased biological value, multivitamin and multivitamin-mineral supplements, as well as natural bioactive substances.
Knowledge and Clinical Practice of Restoration Repair among Dental Undergraduate Students in the Kingdom of Saudi Arabia
Authors: Sibai Norah , AlFadhel Rana , AlSaleh Lama , Durayhim Sarah Bin , AlMthen Haifa , AlSewailem Latifa 
Published: April 2023

Background:
The expeditious advances in minimally invasive dental techniques have led to more conservative treatment options for the repair and refurbishment of defective restorations.

Objectives:
This cross-sectional study aimed to evaluate the knowledge and clinical practices of restoration repair in undergraduate courses in the central region of Saudi Arabia.

Methods:
Data was collected using a survey questionnaire that was distributed using Google forms through social media platforms among undergraduate dental students from different universities in the central region of Saudi.

Results:
A total number of 316 undergraduate students responded, with 77.8% reported having been taught about restoration repair in their undergraduate preclinical courses and 77.2% having practiced restoration repair in their clinical courses. The dominant collective response of the students was that they would opt for repair over replacement to preserve tooth structure and protect the pulp. The most chosen indications for such were the correction of form and partial fractures. Composite was the material of choice for repair, and the students considered the size of the defect to be the most decisive factor in their clinical decision of whether to repair or replace defective restorations.

Conclusion:
The results of this study indicated that restoration repair is taught in preclinical courses and is practiced in the clinic. Students at higher levels are more aware of the procedure and its indications. Based on available evidence, periodic evaluation of clinical teaching strategies, standardization of criteria, and terms are recommended to enhance teaching practice.
Cyclodextrin - Essential Oil Complexes Studied by Thermal
Gravimetry Analysis - Differential Scanning Calorimetry
Authors: Gupta Gaurav R. , Shaikh Vasim R. , Patil Kesharsingh J. 
Published: April 2023

Background:
The structural features allow cyclodextrins to form solid inclusion
complexes (host–guest complexes) with wide variety of solid, liquid, and gaseous compounds
as a guest. It is the utmost an astounding property of the cyclodextrins, and is
commonly termed as molecular recognition. The process of formation of an inclusion
complex of the cyclodextrins has been associated with the substitution of the water inside
the hydrophobic cavity and the non–covalent bonding interactions of the guest in the hydrophobic
host cavity.

Objective:
To study the thermal gravimetry analysis behaviour for α–cyclodextrin–clove
oil, α–cyclodextrin–neem oil and β–cyclodextrin–clove oil adducts using TGA–DSC.

:
To compute specific heat capacity at constant pressure, as a function of temperature for the
studied systems.

Methods:
The thermal gravimetry analysis and differential scanning calorimetry techniques
are used.

Results:
It is observed that the calculated Cp values from DSC curves are of low magnitude
for α–CD–neem oil adduct as compared to that of individual constituents over the temperature
range studied. An interesting pattern for the Cp values is found to emerge in case of α–
CD–clove oil and β–CD–clove oil adducts wherein the calculated Cp values are higher in
magnitude than for pure clove oil but are lower than that of the pure cyclodextrins.

Conclusion:
Using thermal methods, the attempt to understand the possibilities of molecular
complex formation between cyclodextrins and medicinally important neem oil and
clove oil is described. The crystals of inclusion compounds for clove oil and neem oil with
α–CD and β–CD are synthesized. The results of TGA–DSC for the crystals are presented
and analysed.

Other:
The results of neem oil–adducts have been explained in terms of binding of part of
tri–glyceride linkages by 2–3 cyclodextrin molecules as neem oil is tri–glyceride and the
adduct is having lower stability.