bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species: a comparative study
Authors: Feng Yu-Han , Zhang Guo-Dong , Zhu Ping-Chuan , Zhu Wen-Hu , Li You-Zhi , Fan Xian-Wei 
Published: September 2023

Abstract
Background
Lonicera japonica Flos is widely used as a medicinal plant in China owing to its various pharmacological activities. However, little is known about the metabolic profile and antibacterial properties of the leaves of Lonicera species. The present study aimed to determine and compare the metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species.

Results
598 metabolites were identified based metabolomics using UHPLC-Q Exactive Orbitrap MS/MS in the five Lonicera species leaves. Among them, flavonoids and phenols compounds accounted for 13%. In Lonicera dasystyla, 110 differential metabolites were found compared to those in the other Lonicera species, of which flavonoids and phenols accounted for 20% and 10%, respectively. Compared to other Lonicera species leaves, the contents of total phenol, total flavonoid, antioxidant activities and anti-bacterial capacities were considerably higher in Lonicera hypoglauca and lower in L. dasystyla. The contents of total phenol and total flavonoid in L. hypoglauca were 95.86% and 201.64% higher than those in L. dasystyla. The RPA value in L. hypoglauca was 93.27% higher than the value of L. dasystyla, respectively. The content of 4, 5-dicaffeoylquninic acid in L. hypoglauca was 4.814 mg g−1, which was 302.85% higher than that of L. dasystyla. Besides, Chlorogenic acid was most high in leaves of L. japonica and reached 15 mg g−1, which was 209.34% higher than that of L. dasystyla. Moreover, correlation analysis showed most flavonoids, phenols, and coumarins were positively correlated with antioxidant activities and antibacterial capacities.

Conclusions
This study identified the difference of metabolites in leaves of five Lonicera species, antioxidant abilities and inhibition effects of leaf extracts on pathogens, which provides a potential information for further application of Lonicera leaves.

Graphical Abstract
Prediction of extranodal extension in head and neck squamous cell carcinoma by CT images using an evolutionary learning model
Authors: Huang Tzu-Ting , Lin Yi-Chen , Yen Chia-Heng , Lan Jui , Yu Chiun-Chieh , Lin Wei-Che , Chen Yueh-Shng , Wang Cheng-Kang , Huang Eng-Yen , Ho Shinn-Ying 
Published: September 2023

Abstract
Background
Extranodal extension (ENE) in head and neck squamous cell carcinoma (HNSCC) correlates to poor prognoses and influences treatment strategies. Deep learning may yield promising performance of predicting ENE in HNSCC but lack of transparency and interpretability. This work proposes an evolutionary learning method, called EL-ENE, to establish a more interpretable ENE prediction model for aiding clinical diagnosis.

Methods
There were 364 HNSCC patients who underwent neck lymph node (LN) dissection with pre-operative contrast-enhanced computerized tomography images. All the 778 LNs were divided into training and test sets with the ratio 8:2. EL-ENE uses an inheritable bi-objective combinatorial genetic algorithm for optimal feature selection and parameter setting of support vector machine. The diagnostic performances of the ENE prediction model and radiologists were compared using independent test datasets.

Results
The EL-ENE model achieved the test accuracy of 80.00%, sensitivity of 81.13%, and specificity of 79.44% for ENE detection. The three radiologists achieved the mean diagnostic accuracy of 70.4%, sensitivity of 75.6%, and specificity of 67.9%. The features of gray-level texture and 3D morphology of LNs played essential roles in predicting ENE.

Conclusions
The EL-ENE method provided an accurate, comprehensible, and robust model to predict ENE in HNSCC with interpretable radiomic features for expanding clinical knowledge. The proposed transparent prediction models are more trustworthy and may increase their acceptance in daily clinical practice.
ITI consensus report on zygomatic implants: indications, evaluation of surgical techniques and long-term treatment outcomes
Authors: Al-Nawas Bilal , Aghaloo Tara , Aparicio Carlos , Bedrossian Edmond , Brecht Lawrence , Brennand-Roper Matthew , Chow James , Davó Rubén , Fan Shengchi , Jung Ronald , Kämmerer Peer W. , Kumar Vinay V. , Lin Wei-Shao , Malevez Chantal , Morton Dean , Pijpe Justin , Polido Waldemar D. , Raghoebar Gerry M. , Stumpel Lambert J. , Tuminelli Frank J. , Verdino Jean-Baptiste , Vissink Arjan , Wu Yiqun , Zarrine Sepehr 
Published: September 2023

Abstract
Objectives
The aim of the ITI Consensus Workshop on zygomatic implants was to provide Consensus Statements and Clinical Recommendations for the use of zygomatic implants.

Materials and methods
Three systematic reviews and one narrative review were written to address focused questions on (1) the indications for the use of zygomatic implants; (2) the survival rates and complications associated with surgery in zygomatic implant placement; (3) long-term survival rates of zygomatic implants and (4) the biomechanical principles involved when zygoma implants are placed under functional loads. Based on the reviews, three working groups then developed Consensus Statements and Clinical Recommendations. These were discussed in a plenary and finalized in Delphi rounds.

Results
A total of 21 Consensus Statements were developed from the systematic reviews. Additionally, the group developed 17 Clinical Recommendations based on the Consensus Statements and the combined expertise of the participants.

Conclusions
Zygomatic implants are mainly indicated in cases with maxillary bone atrophy or deficiency. Long-term mean zygomatic implant survival was 96.2% [95% CI 93.8; 97.7] over a mean follow-up of 75.4 months (6.3 years) with a follow-up range of 36–141.6 months (3–11.8 years). Immediate loading showed a statistically significant increase in survival over delayed loading. Sinusitis presented with a total prevalence of 14.2% [95% CI 8.8; 22.0] over a mean 65.4 months follow-up, representing the most common complication which may lead to zygomatic implant loss. The international experts suggested clinical recommendations regarding planning, surgery, restoration, outcomes, and the patient’s perspective.
Are anxious and mixed depression two sides of the same coin? Similarities and differences in patients with bipolar I, II and unipolar disorders
Authors: Tundo Antonio , Musetti Laura , Betrò Sophia , Cambiali Erika , de Filippis Rocco , Marazziti Donatella , Mucci Federico , Proietti Luca , Dell’Osso Liliana 
Published: September 2023

Abstract

Background
Diagnostic criteria are not always useful to discriminate major depression with anxious distress (ADS-D; Diagnostic and Statistical Manual for Mental Disorders, version-5 [DSM-5] criteria) from mixed depression (Koukopoulos’ criteria; KMX-D). So, clinicians need alternative tools to improve their diagnostic ability and to choose the most appropriate treatment. The aim of the present study is to identify socio-demographic and clinical features that discriminate patients with ADS-D from those with KMX-D.

Methods
Two hundred and forty-one consecutive outpatients with unipolar (51%) and bipolar (49%) disorder, fulfilling DSM-5 criteria for a current major depressive episode (MDE) and with a 21-item Hamilton Depression Rating Scale score ≥ 14, were recruited and treated in a prospective observational study.

Results
Ten percent of patients met criteria for KMX-D, 22% ADS-D, and 37% for both. Irritable premorbid temperament, mixed depression polarity at onset, mixed depression recurrence, and a high number of mania symptoms at intake were typical features of patients with KMX-D. Depressive polarity at onset, a low number of mania symptoms at intake, and generalized anxiety disorder comorbidity were typical features of patients with ADS-D. Multinomial logistic regression confirmed that higher rate of irritable temperament and higher Young Mania Rating Scale total score differentiated patients with KMX-D from patients with pure MDE.

Conclusion
Our findings suggest some clinical features that could help differentiate between ADS-D and KMX-D in patients meeting both conditions and to select the appropriate treatment. However, the small sample size may have limited the power to detect differences between the groups. Further research is needed to confirm the results of present study.
Recent advances in insect thermoregulation
Authors: Lahondère Chloé 
Published: September 2023

ABSTRACTAmbient temperature (Ta) is a critical abiotic factor for insects that cannot maintain a constant body temperature (Tb). Interestingly, Ta varies during the day, between seasons and habitats; insects must constantly cope with these variations to avoid reaching the deleterious effects of thermal stress. To minimize these risks, insects have evolved a set of physiological and behavioral thermoregulatory processes as well as molecular responses that allow them to survive and perform under various thermal conditions. These strategies range from actively seeking an adequate environment, to cooling down through the evaporation of body fluids and synthesizing heat shock proteins to prevent damage at the cellular level after heat exposure. In contrast, endothermy may allow an insect to fight parasitic infections, fly within a large range of Ta and facilitate nest defense. Since May (1979), Casey (1988) and Heinrich (1993) reviewed the literature on insect thermoregulation, hundreds of scientific articles have been published on the subject and new insights in several insect groups have emerged. In particular, technical advancements have provided a better understanding of the mechanisms underlying thermoregulatory processes. This present Review aims to provide an overview of these findings with a focus on various insect groups, including blood-feeding arthropods, as well as to explore the impact of thermoregulation and heat exposure on insect immunity and pathogen development. Finally, it provides insights into current knowledge gaps in the field and discusses insect thermoregulation in the context of climate change.
Decentralized Platforms: Governance, Tokenomics, and ICO Design
Authors: Gan Jingxing (Rowena) , Tsoukalas Gerry , Netessine Serguei 
Published: September 2023

Traditional two-sided platforms (e.g., Amazon, Uber) rely primarily on commission contracts to generate revenues and fuel growth, whereas their decentralized counterparts (e.g., Uniswap, Filecoin) often forego these in favor of token retention. What economics underpin this choice? We show that with properly designed initial coin offerings (ICOs), both mechanisms can independently alleviate market failures at the initial fundraising stage and incentivize long-term platform building. However, they achieve this in different ways. Although commission contracts often lead to higher profits for founders, token retention leads to higher service levels, benefiting the users and service providers. In essence, token retention surrenders a fraction of earnings to better align with the tenets of decentralized governance. Combining both mechanisms can add value, but only in relatively limited cases. These findings offer guidance and a possible rationale for why platforms may want to favor one mechanism over the other or use both.This paper was accepted by Will Cong, Special Section of Management Science: Blockchains and Crypto Economics.Funding: This work is funded by the Mack Institute at the Wharton School, University of Pennsylvania.Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2021.02076 .
Treatment of infected bone defects with the induced membrane technique
Authors: Shen Jie , Wei Zhiyuan , Wang Shulin , Wang Xiaohua , Lin Wei , Liu Lei , Wang Guanglin 
Published: September 2023

AimsThis study aimed to evaluate the effectiveness of the induced membrane technique for treating infected bone defects, and to explore the factors that might affect patient outcomes.MethodsA comprehensive search was performed in PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases between 1 January 2000 and 31 October 2021. Studies with a minimum sample size of five patients with infected bone defects treated with the induced membrane technique were included. Factors associated with nonunion, infection recurrence, and additional procedures were identified using logistic regression analysis on individual patient data.ResultsAfter the screening, 44 studies were included with 1,079 patients and 1,083 segments of infected bone defects treated with the induced membrane technique. The mean defect size was 6.8 cm (0.5 to 30). After the index second stage procedure, 85% (797/942) of segments achieved union, and 92% (999/1,083) of segments achieved final healing. The multivariate analysis with data from 296 patients suggested that older age was associated with higher nonunion risk. Patients with external fixation in the second stage had a significantly higher risk of developing nonunion, increasing the need for additional procedures. The autografts harvested from the femur reamer-irrigator-aspirator increased nonunion, infection recurrence, and additional procedure rates.ConclusionThe induced membrane technique is an effective technique for treating infected bone defects. Internal fixation during the second stage might effectively promote bone healing and reduce additional procedures without increasing infection recurrence. Future studies should standardize individual patient data prospectively to facilitate research on the affected patient outcomes.Cite this article: Bone Joint Res 2023;12(9):546–558.
EDUCAÇÃO AMBIENTAL: UM PROCESSO DE CONSCIENTIZAÇÃO ECOLÓGICA
Authors: Silva Lago Lisiane , Carvalhal Britio Ivomar 
Published: September 2023

A imensa capacidade do homem em modificar o ambiente vem se revelando como uma faca de dois gumes, se por um lado, o desenvolvimento de técnicas agrícolas, a criação de animais e o avanço técnico-científico aumentaram as possibilidades de sobrevivência da nossa espécie, por outro lado, causaram sérias alterações no ambiente. O crescimento exponencial da população humana passou a exigir um aumento também exponencial de exploração da natureza para a produção de energia e alimento. Esta exploração não foi programada de modo a garantir a renovação e uso racional dos recursos naturais nem a conscientização por todos da necessidade de preservação do meio ambiente, para assegurar a boa qualidade de vida, sem a quai de nada adianta o "progresso".
REFLEXÕES SOBRE A GÊNESE DAS PROFISSÕES DE SAÚDE: ENFERMAGEM, PSICOLOGIA E TERAPIA OCUPACIONAL
Authors: Araújo Assis Marluce Maria , Castilho Françoso Luciana Pagano , Bressan Costa Lúcia 
Published: September 2023

Este texto tem por objeto central de análise a gênese das profissões de saúde: Enfermagem, Psicologia e Terapia Ocupacional articulada à própria história da Medicina, tomando como fio condutor a visão do filósofo francês MICHEL FOUCAULT, no momento da configuração da Medicina Moderna — fins do século XVIII e início do século XIX — que passa a entender o corpo enquanto força de trabalho e força de produção e, em decorrência, as diferentes formas de tratar as questões da saúde em diferentes contextos, no processo de socialização e medicalização. Neste processo, apontamos o nascimento dessas profissões como necessidades sociopolíticas, tentando fazer uma discussão acerca desses “saberes” e “práticas”, refletindo a dominação de classes sociais, sob a hegemonia da classe médica.
CRIAÇÃO LITERÁRIA
Authors: Vilma Ângela , Cerqueira Anne , Machado Franklin , Gomes Lopes George Luiz , Alves Jecilma , Morais José Jerônimo , De La Orden Luiz , Bispo Maisa , Gomes de Melo Norma , Borges Outran , Lopes Raymundo Luiz , Mattos Sergio , Vasconcelos Suani , Siqueira Alves Telma 
Published: September 2023

Entre esses homens sem grande apetite pela poesia, que não conhecem a necessidade dela e que não a teriam inventado, quer o infortúnio que figure uma quantidade desses cuja tarefa ou destino é julgá-la, discorrer sobre ela, estimulá-la ou cultivar o gosto por ela; e, em suma, distribuir o que eles não têm. A isso dedicam, com fre- qüência, toda a sua inteligência e todo o seu zelo: e disso podem resultar conseqüências temíveis.
- Paul Valéry -
High-speed 2D beam steering based on a thin-film lithium niobate optical phased array with a large field of view
Authors: Li Wenlei , Zhao Xu , He Jianghao , Yan Hao , Pan Bingcheng , Guo Zichen , Han Xiang’e , Chen Jingye , Dai Daoxin , Shi Yaocheng 
Published: September 2023

An on-chip optical phased array (OPA) is considered as a promising solution for next generation solid-state beam steering. However, most of the reported OPAs suffer from low operating bandwidths, making them limited in many applications. We propose and demonstrate a high-speed 2D scanning OPA based on thin-film lithium niobate phase modulators with traveling-wave electrodes. The measured modulation bandwidth is up to 2.5 GHz. Moreover, an aperiodic array combined with a slab grating antenna is also used to suppress the grating lobes of far-field beams, which enables a large field of view (FOV) as well as small beam width. A 16-channel OPA demonstrates an FOV of 50°×8.6° and a beam width of 0.73°×2.8° in the phase tuning direction and the wavelength scanning direction, respectively.
Long-term effectiveness and safety of infliximab-biosimilar: A multicenter Phoenix retrospective cohort study
Authors: Kazama Tomoe , Ando Katsuyoshi , Ueno Nobuhiro , Fujiya Mikihiro , Ito Takahiro , Maemoto Atsuo , Ishigami Keisuke , Nojima Masanori , Nakase Hiroshi 
Published: September 2023

Background
Infliximab (IFX) effectively treats patients with inflammatory bowel disease (IBD). IFX-biosimilar (IFX-BS) has the same amino acid sequence as that of the IFX originator, and its increasing use is expected to reduce national healthcare costs. Long-term efficacy and safety of IFX-BS in patients with Crohn’s disease (CD) and ulcerative colitis (UC) have not been completely investigated.

Methods
We conducted a retrospective, multicenter observational study of patients with IBD who received IFX-BS treatment at three hospitals between October 2016 and April 2022. Clinical data were collected from electronic medical records and evaluated for achieving clinical remission (CR) using Crohn’s disease activity index (CDAI) and partial Mayo (pMayo) score, persistency of long-term IFX-BS administration, and clinical response rate in the bio-naïve and bio-failure groups.

Results
A total of 117 patients with IBD (90 CD and 27 UC) were included. The study findings indicated that both bio-naïve and bio-failure groups of patients with UC showed similar effectiveness of IFX-BS. The treatment persistence rate in patients with CD was significantly higher in the bio-naïve (P = 0.042) and switch (P = 0.010) groups than in the bio-failure group. In the former two groups, the treatment persistence rate was high at two years after administration (more than 80%). In patients with UC, the findings indicated higher treatment persistence rate in the switch group than in the bio-naïve group. Univariable and multivariable analyses for treatment persistence rate showed that the albumin level at the initial IFX-BS administration and groups (bio-naïve, bio-failure and switch) were effective factors for patients with CD. Adverse events were reported in 18 patients (15.4%).

Conclusion
The present study demonstrates the long-term effectiveness and safety of IFX-BS. In addition to the favorable remission induction in the bio-naïve and bio-failure groups, we demonstrated remission maintenance and treatment persistence rates beyond two years. Albumin level and groups were associated with better treatment persistence in patients with CD.
Rapid increase in immune surveillance and expression of NKT and γδT cell activation markers after consuming a nutraceutical supplement containing Aloe vera gel, extracts of Poria cocos and rosemary. A randomized placebo-controlled cross-over trial
Authors: Yu Liu , McGarry Sage , Cruickshank Dina , Jensen Gitte S. 
Published: September 2023

GoalTo evaluate the acute impact of a nutraceutical blend on immune surveillance.Study designA randomized, double-blind, placebo-controlled, cross-over trial was conducted in 11 healthy subjects. Blood samples were taken immediately before and at 1, 2, and 3 hours after consuming placebo or 500 mg of UP360, which is a blend of botanicals fromAloe vera,Poria cocos, and rosemary (APR extract). Immunophenotyping and flow cytometry quantified numbers of monocytes, NK cells, NKT cells, CD8+ cytotoxic T cells, γδT cells, and total T cells, and expression of CD25 and CD69 activation markers. Plasma was tested for cytokines, chemokines, growth factors, and enzymatic activity of superoxide dismutase and catalase.ResultsCompared to the placebo, consumption of APR extract triggered rapid increases in chemokine levels starting at 1 hour, including IP-10 (P<0.05) and MCP-1 (P<0.1), which peaked at 2 hours (P<0.01) and 3 hours (P<0.05), respectively. The stem cell-mobilizing growth factor G-CSF increased at 2 hours (P<0.05). Increased immune surveillance involved a transient effect for monocytes at 1 hour, followed by NKT cells, CD8+ cytotoxic T cells, and γδT cells at 2–3 hours. Increased immune cell alertness was seen at 1 hour by increased CD25 expression on monocytes (P<0.01), NKT cells (P<0.01), and T cells (P<0.05). NKT cells showed upregulation of CD69 at 2 hours (P<0.01). Increased enzymatic activity was seen at 2 hours for the antioxidant enzymes superoxide dismutase (P<0.05) and catalase (P<0.01).ConclusionConsumption of APR extract triggered acute changes to chemokine levels. In addition, immune alertness was increased via the expression of activation markers on multiple types of innate immune cells, followed by increased immune surveillance and antioxidant protection. This suggests a beneficial enhancement of natural immune surveillance, likely via a combination of gut-mediated cytokine release and vagus nerve communication, in combination with cellular protection from oxidative stress.