bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes
Authors: Wretlind Asger , Curovic Viktor R. , Suvitaival Tommi , Theilade Simone , Tofte Nete , Winther Signe A. , Vilsbøll Tina , Vestergaard Henrik , Rossing Peter , Legido-Quigley Cristina 
Published: July 2023

Ceramides are lipid molecules involved in inflammation-related signaling. Recent studies have shown that higher amounts of specific circulating ceramides and their ratios are associated with future development of cardiovascular (CV) disease (CVD). We examined the associations between serum ceramide levels with CVD, kidney failure, and all-cause mortality in individuals with long-standing type 1 diabetes (T1D). We included 662 participants with T1D and 6-year follow-up, with a mean age of 55 years and mean diabetes duration of 33 years. Baseline serum samples were analyzed using liquid chromatography–mass spectrometry. Six predefined ceramide levels were measured, and predefined ratios were calculated. Adjusted Cox regression analyses on ceramide levels in relation to future CV events (CVE), kidney failure, and all-cause mortality were performed, with and without adjustment for age, sex, BMI, LDL, triglycerides, systolic blood pressure, HbA1c, history of CVD, smoking status, statin use, estimated glomerular filtration rate (eGFR), and urinary albumin excretion rate (UAER). The ceramide ratio cer(d18:1/18:0)/cer(d18:1/24:0) was significantly associated with risk of CVE (hazard ratio [HR] = 1.33, P = 0.01) and all-cause mortality (HR = 1.48, P = 0.01) before and after adjustments. All five investigated ceramide ratios were associated with kidney failure, before adjusting for the kidney markers eGFR and UAER. In this study, we demonstrate specific ceramides and ratios associated with 6-year cardiovascular risk and all-cause mortality in a T1D cohort. This highlights the strength of ceramide association with vascular complications and presents a new potential tool for early risk assessment if validated in other cohorts.

Article Highlights
Improved tools for assessing risk for diabetes complication before onset will help in complication prevention. We investigated a set of six predefined ceramides and their ratios versus 6-year outcomes of cardiovascular events, kidney failure, and all-cause mortality in people with long-standing type 1 diabetes, using Cox regression with and without adjustment for potential confounders. We found that several ceramides and ceramide ratios associated with cardiovascular events and all-cause mortality. The ratio of cer(d18:1/18:0)/cer(d18:1/24:0) was an especially robust marker. These finding show that ceramides can be biomarkers of cardiovascular disease and all-cause mortality in individuals with long-standing type 1 diabetes.
Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes
Authors: Schön Martin , Zaharia Oana P. , Strassburger Klaus , Kupriyanova Yuliya , Bódis Kálmán , Heilmann Geronimo , Strom Alexander , Bönhof Gidon J. , Michelotti Filippo , Yurchenko Iryna , Möser Clara , Huttasch Maximilian , Bombrich Maria , Kelm Malte , Burkart Volker , Schrauwen-Hinderling Vera B. , Wagner Robert , Roden Michael ,   GDS Group, Roden M. , Al-Hasani H. , Belgardt B. , Bönhof G.J. , Burkart V. , Buyken A.E. , Geerling G. , Herder C. , Icks A. , Jandeleit-Dahm K. , Kotzka J. , Kuß O. , Lammert E. , Rathmann W. , Schrauwen-Hinderling V. , Szendroedi J. , Trenkamp S. , Wagner R. 
Published: July 2023

Intramyocellular lipid content (IMCL) is elevated in insulin-resistant humans, but it changes over time, and relationships with comorbidities remain unclear. We examined IMCL during the initial course of diabetes and its associations with complications. Participants of the German Diabetes Study (GDS) with recent-onset type 1 (n = 132) or type 2 diabetes (n = 139) and glucose-tolerant control subjects (n = 128) underwent 1H-MRS to measure IMCL and muscle volume, whole-body insulin sensitivity (hyperinsulinemic-euglycemic clamps; M-value), and cycling spiroergometry (VO2max). Subgroups underwent the same measurements after 5 years. At baseline, IMCL was ∼30% higher in type 2 diabetes than in other groups independently of age, sex, BMI, and muscle volume. In type 2 diabetes, the M-value was ∼36% and ∼62% lower compared with type 1 diabetes and control subjects, respectively. After 5 years, the M-value decreased by ∼29% in type 1 and ∼13% in type 2 diabetes, whereas IMCL remained unchanged. The correlation between IMCL and M-value in type 2 diabetes at baseline was modulated by VO2max. IMCL also associated with microalbuminuria, the Framingham risk score for cardiovascular disease, and cardiac autonomic neuropathy. Changes in IMCL within 5 years after diagnosis do not mirror the progression of insulin resistance in type 2 diabetes but associate with early diabetes-related complications.

Article Highlights
Intramyocellular lipid content (IMCL) can be elevated in insulin-resistant humans, but its dynamics and association with comorbidities remain unclear. Independently of age, sex, body mass, and skeletal muscle volume, IMCL is higher in recent-onset type 2, but not type 1 diabetes, and remains unchanged within 5 years, despite worsening insulin resistance. A degree of physical fitness modulates the association between IMCL and insulin sensitivity in type 2 diabetes. Whereas higher IMCL associates with lower insulin sensitivity in people with lower physical fitness, there is no association between IMCL and insulin sensitivity in those with higher degree of physical fitness. IMCL associates with progression of microalbuminuria, cardiovascular disease risk, and cardiac autonomic neuropathy.
<strong>Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling </strong>
Authors: Sohn Paul , R. McLaughlin Madeline , Krishnan Preethi , Wu Wenting , Slak Rupnik Marjan , Takasu Akira , Senda Toshiya , Lee Chih-Chun , Kono Tatsuyoshi , Evans-Molina Carmella 
Published: July 2023

<p>Altered endoplasmic reticulum (ER) Ca2+ signaling has been linked with β cell dysfunction and diabetes development. Store-operated Ca2+ entry (SOCE) replenishes ER Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). To characterize the <em>in vivo</em> impact of STIM1 loss, mice with a β cell-specific STIM1 deletion (STIM1Δβ mice) were generated and challenged with high-fat diet. Interestingly, β cell dysfunction was observed in female, but not male, mice. Female STIM1Δβ mice displayed reductions in β cell mass, a concomitant increase in α cell mass, and reduced expression of markers of β cell maturity, including MafA and UCN3. Consistent with these findings, STIM1 expression was inversely correlated with HbA1c levels in islets from female, but not male, organ donors. Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in STIM1Δβ mice was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor (GPER1), as GPER1 knockdown and inhibition led to a similar loss of expression of β cell maturity genes in INS-1 cells. Together, these data suggest that STIM1 orchestrates pancreatic β cell function and identity through GPER1-mediated estradiol signaling. </p>
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IMPLEMENTASI GOOGLE FORM SEBAGAI MEDIA EVALUASI PEMBELAJARAN BAHASA INGGRIS DI SMP NEGERI 21 SEMARANG
Authors: Andika Tri , Sumardiyani Listyaning , Nur Ardini Sukma , Lupiani Lilis Endah 
Published: July 2023

This research is based on the potential that can be utilized from smartphone devices that can be developed to facilitate a teacher in terms of learning evaluation. This study aims to describe the implementation and response of practicing teachers to the use of Google Forms as an evaluation medium for learning English at SMPN 21 Semarang. The approach used is qualitative by using a qualitative descriptive method. The implementation of Google Form as an evaluation medium for learning English at SMPN 21 Semarang became the object of research, and practicing teachers of English subjects became the research subjects. The results of this study indicate that: (1) The implementation of the Google Form as an evaluation medium for learning English at SMPN 21 Semarang in general has been put to good use, since the preparation of the evaluation plan for learning outcomes, collecting data, conducting data verification, processing and analyzing data, providing interpretation and draw conclusions and follow-up from the teacher. (2) The teacher gave a good response based on aspects of effectiveness, time, cost, use, attractiveness, and benefits.Keyword: E-learning, Evaluation, Google Form Penelitian ini berdasarkan pada potensi yang dapat dimanfaatkan dari perangkat smartphone yang bisa dikembangkan untuk mempermudah seorang guru dalam hal evaluasi pembelajaran. Penelitian ini bertujuan untuk mendeskripsikan mengenai bagaimana pengimplementasian dan respon guru praktikan terhadap pemanfaatan Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang. Pendekatan yang digunakan adalah kualitatif dengan menggunakan metode deskriptif kualitatif. Implementasi Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang menjadi obyek penelitian, dan guru praktikan mata Bahasa Inggris menjadi subyek penelitian. Hasil penelitian ini menunjukkan bahwa: (1) Pengimplementasian Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang secara umum telah dimanfaatkan secara baik, sejak penyusunan rencana evaluasi hasil belajar, menghimpun data, melakukan verifikasi data, mengolah dan menganalisis data, memberikan interpretasi dan menarik kesimpulan serta adanya tindak lanjut dari guru. (2) Guru memberikan respon baik berdasarkan aspek - aspek efektivitas tenaga, waktu, biaya, penggunaan, kemenarikan, dan manfaat.Kata Kunci: E-learning, Evaluasi, Google Form
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA PADA TEMA LINGKUNGAN SAHABAT KITA DI KELAS V SD NEGERI 081235 SIBOLGA TAHUN PEMBELAJARAN 2022/2023
Authors: Pasaribu Helen Everiany , Anzelina Dewi , Sitepu Anton , Gaol Rumiris Lumban , Simarmata Ester Julinda , Sinaga Reflina 
Published: July 2023

This Classroom Action Research (CAR) focuses on improving the critical thinking skills of fifth grade students at SD Negeri 081235 Sibolga for the 2022/2023 academic year by utilizing the Problem Based Learning learning model for subject 8 Our Friendly Environment. Two research cycles were conducted. 30 class V children of SD Negeri 081235 Sibolga were used as research subjects. Based on the research findings, it can be concluded that fifth grade students at SD Negeri 08235 Sibolga for the 2022/2023 academic year are increasingly proficient in using critical thinking when studying the sub-theme Changes in the learning environment 1 and the main theme Our Friends. Environment. Based on the research findings, 13 students or 43% obtained a complete score for cycle I, while 17 students or 57% did not complete with an average score of 70.41%. In cycle II there were 25 students who did not complete or 83% of the class, and 5 students who did not complete or 17% of the class with an average value of 83%. The action was abandoned in cycle II because it met the completeness requirements, so it was concluded that the learning topic Our Environment is a Friend in class V SD Negeri 081235 Sibolga is improved with a Problem Based Learning learning approach.Keyword: Critical Thinking Ability, Learning Model, Problem Based Learning Penelitian Tindakan Kelas (PTK) ini berfokus pada peningkatan kemampuan berpikir kritis siswa kelas V SD Negeri 081235 Sibolga Tahun Pelajaran 2022/2023 dengan memanfaatkan model belajar Problem Based Learning terhadap mata pelajaran 8 Lingkungan Sahabat Kita. Dua siklus penelitian dilakukan. 30 anak kelas V SD Negeri 081235 Sibolga dijadikan sebagai subjek penelitian. Berdasarkan temuan penelitian bisa diambil simpulan jika siswa kelas V SD Negeri 08235 Sibolga Tahun Pelajaran 2022/2023 semakin mahir menggunakan berpikir kritis ketika mempelajari subtema Perubahan lingkungan belajar 1 dan tema utama Teman Kita. Lingkungan. Berdasarkan temuan penelitian, 13 siswa atau 43% memperoleh nilai tuntas terhadap siklus I, sedangkan 17 siswa atau 57% tidak tuntas dengan nilai rata-rata 70,41%. Dalam siklus II ada 25 siswa yang tidak tuntas atau 83% kelas, dan 5 siswa yang tidak tuntas atau 17% kelas dengan nilai rata-rata 83%. Tindakan ditinggalkan dalam siklus II sebab memenuhi syarat ketuntasan, sehingga didapati kesimpulan jika topik pembelajaran Lingkungan Kita Sahabat di kelas V SD Negeri 081235 Sibolga ditingkatkan dengan pendekatan pembelajaran Problem Based Learning.Kata Kunci: Kemampuan Berpikir Kritis, Model Pembelajaran, Problem Based Learning
KAJIAN PENDEKATAN PEMBELAJARAN REALISTIC MATHEMATIC EDUCATION UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SD: ANALISIS LITERATUR
Authors: Laudia Stefanie Marla , Purwoko Budi 
Published: July 2023

This study aims to determine the improvement of elementary students’ mathematical problem-solving skills taught by Realistic Mathematic Education approach. The research method is a literature review. Data collection in this research is done by searching journal through Google Scholar. Keywords used for journal searching are: Classroom Action Research, Realistic Mathematic Education, problem solving, and Mathematic elementary. Subsequently, 15 Classroom Action Research articles were selected and further analyzed. Based on the analysis result, it can be concluded that the Realistic Mathematics Education approach can enhance elementary school students' problem-solving skills in mathematics. The improvement in problem-solving skills ranged from a minimum of 11.67% to a maximum of 70%.Keyword: Realistic Mathematic Education, Problem Solving, Elementary Mathematic, Literature Review Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan pemecahan masalah matematika siswa SD yang diajarkan melalui Pendekatan Matematika Realistik. Metode penelitian yang digunakan adalah analisis literatur. Pengumpulan data dalam penelitian ini dilakukan dengan menelusuri jurnal melalui Google Cendekia. Kata kunci yang digunakan untuk penelusuran jurnal adalah: Penelitian Tindakan Kelas, Pendekatan Matematika Realistik, kemampuan pemecahan masalah, dan matematika SD. Kemudian terpilihlah 15 artikel Penelitian Tindakan Kelas yang dianalisis lebih lanjut. Berdasarkan hasil analisis dari 15 artikel, dapat disimpulkan bahwa Pendekatan Matematika Realistik dapat meningkatkan kemampuan pemecahan masalah matematika SD. Peningkatan kemampuan pemecahan masalah bervariasi dari yang terendah 11,67% sampai yang tertinggi 70%.Kata Kunci: Pendekatan Matematika Realistik, Kemampuan Pemecahan Masalah, Matematika SD, Kajian Literatur
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF MODEL THINK PAIR SHARE BERBASIS ARTICULATE STORYLINE PADA TEMA 6 SUBTEMA 1 KELAS IV SD NEGERI 105282 GALANG
Authors: Ricca Andar , Simanihuruk Lidia 
Published: July 2023

This study aims to determine the level of feasibility, practicality, and effectiveness of the interactive learning media Think Pair Share model based on Articulate Storyline in Theme 6 Subtheme 1 Learning 3 Class IV-B SD Negeri 105382 Galang T.A 2022/2023. This type of research is R&D with the ADDIE development model. Data collection techniques in this study consisted of observation and interviews, questionnaires and tests. The instruments used in this study included interview instruments, expert instruments (questions, tests, media, and materials), practical instruments (teacher and student response questionnaires), and learning achievement tests. Data analysis techniques used in this research are qualitative data and quantitative data. The results of this study indicate that the interactive learning media Think Pair Share model based on Articuate Storyline on theme 6 subtheme 1 learning 3 is declared feasible, practical, and effective for use in learning. Based on the feasibility results, the product gets a percentage of 75% and is included in the feasible category. Product practicality results get a percentage of 94% and are included in the very practical category. Product effectiveness results get a percentage of 69% and are included in the effective category.Keyword: Interactive Media, TPS, Articulate Storyline Penelitian ini bertujuan untuk mengetahui tingkat kelayakan, praktikalitas, dan keefektifan dari media pembelajaran interaktif model Think Pair Share berbasis Articulate Storyline pada Tema 6 Subtema 1 Pembelajaran 3 Kelas IV-B SD Negeri 105382 Galang T.A 2022/2023. Jenis penelitian ini adalah R&D dengan model pengembangan ADDIE. Teknik pengumpulan data dalam penelitian ini terdiri atas observasi dan wawancara, angket, dan tes. Adapun instrumen yang digunakan dalam penelitian ini meliputi instrumen wawancara, instrumen ahli (angket, tes, media, dan materi), instrumen praktikalitas (angket respon guru dan siswa), dan tes hasil belajar. Teknik analisis data yang digunakan dalam penelitian ini adalah data kualitatif dan data kuantitatif. Hasil penelitian ini menunjukkan bahwa media pembelajaran interaktif model Think Pair Share berbasis Articuate Storyline pada tema 6 subtema 1 pembelajaran 3 dinyatakan layak, praktis, dan efektif digunakan dalam pembelajaran. Berdasarkan hasil kelayakan produk mendapatkan persentase 75% dan termasuk kategori layak. Hasil praktikalitas produk mendapatkan persentase 94% dan termasuk kategori sangat praktis. Hasil efektifitas produk mendapatkan persentase 69% dan termasuk kategori efektif.Kata Kunci: Media Interaktif, TPS, Articulate Storyline
UPAYA MENINGKATKAN HASIL BELAJAR MATEMATIKA PADA MATERI PECAHAN MELALUI PERMAINAN MONOPOLI PECAHAN
Authors: Mailani Elvi 
Published: July 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan matematika siswa pada materi pecahan siswa kelas IV SDS Inti Nusantara kota Tebing Tinggi. Penelitian ini adalah penelitian tindakan kelas. Penelitian ini dilaksanakan sebanyak 2 siklus. Subjek pada penelitian ini berjumlah 32 siswa. Analisis data pada penelitian ini dikumpulkan melalui kegiatan unjuk kerja, lembar observasi, dan tes. Pada kegiatan pra Siklus rata rata kemampuan siswa sebesar 44,7%. Setelah dilakukan tindakan pada siklus I, rata-rata kemampuan menjadi 72,8%. Pada siklus II, rata-rata kemampuan siswa meningkat lagi mencapai 91,6%. Terjadi peningkatan 46,9 % dari pra siklus sampai dengan siklus II terhadap kemampuan matematika pada materi pecahan siswa kelas IV SDS Inti Nusantara kota tebing Tinggi dan dengan demikian maka penelitian ini dikatakan berhasil. Kata Kunci : hasil belajar , monopoli pecahan, matematika
KEARIFAN LOKAL KEMPONAN PADA MASYARAKAT MELAYU DESA SUNGAI KUNYIT LAUT KABUPATEN MEMPAWAH DALAM PANDANGAN AQIDAH DAN AKHLAK ISLAM
Authors: Miranda Siska , Rianawati Rianawati , Susanto Rizki 
Published: July 2023

Abstract: The purpose of this study was to examine the local wisdom of kemponan which is still carried out by the Malay community. Kemponan is an expression related to the activity of offering food and drink to other people who have a causal bond when they refuse the offer. This study uses qualitative research to gather information from the community, religious, customary, and community leaders who still apply "kemponan" in their daily lives. The Kemponan which is considered mystical is then analyzed in terms of Islamic aqidah and morals to find the cultural link between the culture and the Muslim community who carry it out. Keywords: local wisdom, kemponan, and Islamic worldview
High Quality Multi-Zone and 3D CFD Model of Combustion in Marine Diesel Engine Cylinder
Authors: Cuper-Przybylska Dominika , Nguyen Van Nhanh , Nam Cao Dao , Kowalski Jerzy 
Published: July 2023

Abstract
The paper presents a 3D model of the processes taking place in the cylinder of a large 4-stroke marine engine. The model is based on CFD calculations performed on the moving mesh. The modelling range includes the full duty cycle (720° crankshaft position) and the complete geometry of the cylinder with inlet and exhaust ducts. The input data, boundary conditions and validation data were obtained by direct measurements on the real object. Fuel injection characteristics were obtained by Mie scattering measurements in a fixed-volume chamber. The modelling results have been validated in terms of the pressure characteristics of the engine’s cylinder within the entire range of its loads. The mean error did not exceed 1.42% for the maximum combustion pressure and 1.13% for the MIP (Mean Indicated Pressure). The model was also positively validated in terms of the O2 and NOx content of the exhaust gas. The mean error in this case was 1.2% for NOx fractions in the exhaust gas and 0.4% for O2 fractions. The complete model data has been made available in the research data repository on an open access basis.
Health Monitoring of a Compression Ignition Engine Fed with Different Low-Sulphur Marine Fuels by Endoscopic Image Processing and Analysis
Authors: Korczewski Zbigniew 
Published: July 2023

Abstract
This article characterises the methodology for the endoscopic testing of a laboratory diesel engine used for testing marine fuels. The ‘Shadow’ measurement method used in the XLG3 type EVEREST digital endoscope, for quantitative and qualitative identification of detected surface defects, was approximated. Representative endoscopic images of the elements limiting the working space of the research engine are demonstrated, having been recorded during the usable quality testing of newly produced, low-sulphur marine fuels, so-called ‘modified fuels’. The main purpose of the endoscopic examinations was the final verification of the tested fuel’s suitability for feeding full-size marine engines.
Evaluation of Geometrical Influence on the Hydrodynamic Characteristics and Power Absorption of Vertical Axisymmetric Wave Energy Converters in Irregular Waves
Authors: Zhang Wanchao , Zhu Yang , Liu Shuxu , Wang Jianhua , Zhang Wentian 
Published: July 2023

Abstract
To obtain the mechanical energy of waves from arbitrary directions, the vibration absorbers of wave energy converters (WEC) are usually vertically axisymmetric. In such case, the wave-body interaction hydrodynamics is an essential research topic to obtain high-efficiency wave energy. In this paper, a semi-analytical method of decomposing the complex axisymmetric boundary into several ring-shaped stepped surfaces based upon the boundary approximation method (BAM) is introduced and examined. The hydrodynamic loads and parameters, such as the wave excitation forces, added mass and radiation damping of the vertical axisymmetric oscillating buoys, can then be achieved by using the new boundary discretisation method. The calculations of the wave forces and hydrodynamic coefficients show good convergence with the number of discretisation increases. Comparison between the constringent results and the results of the conventional method also verifies the feasibility of the method. Then, simulations and comparisons of the hydrodynamic forces, motions and wave power conversions of the buoys with series draught and displacement ratios in regular and irregular waves are conducted. The calculation results show that the geometrical shape has a great effect on the hydrodynamic and wave power conversion performance of the absorber. In regular waves, though the concave buoy has the lowest wave conversion efficiency, it has the largest frequency bandwidth for a given draught ratio, while in irregular waves, for a given draught ratio, the truncated cylindrical buoy has the best wave power conversion, and for a given displacement of the buoy, the concave buoy shows the best wave power conversion ability.