bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not easy to ‘green’ old ways: National courts and rights‐based smog cases in Poland
Authors: Karpus Karolina 
Published: March 2023

AbstractThe topic of environmental rights has been intensely debated at the international and European levels. It is closely connected to another important issue, namely, the role of rights‐based litigation in the enforcement of environmental law. In Poland, members of the public have tried to use the strategy of environmental rights‐based litigation to target ineffective air quality plans. However, existing barriers in access to justice impelled the public concerned to resort to civil lawsuits as another form of private enforcement of ambient air protection measures. The infringement of the right to a clean environment was among the legal arguments presented for the purpose of establishing Poland's liability for smog. The 2021 landmark rulings in the so‐called ‘smog cases’ exemplify how the judiciary's willingness to embrace the concept of environmental rights in its current form can be limited by concerns about the coherence of the national legal system.
Genesis of island dolostones during rapid island subsidence: Example from the Xisha (Paracel) islands, South China Sea
Authors: Li Rong , Jones Brian , Qiao Peijun , Cui Yuchi , Pei Jianxiang , Liu Xinyu , Shao Lei 
Published: March 2023

AbstractMiocene carbonate successions found on many isolated oceanic islands throughout south‐east Asia commonly include unconformity capped ‘island dolostones’ units. On Shidao, located in the Xisha Islands in the South China Sea, well XK‐1 (1268.2 m deep) penetrated a thick succession of carbonates before being terminated in the Jurassic metamorphic basement. The lower part of the succession is composed of the Sanya Formation (Early Miocene) and the overlying Meishan Formation (Middle Miocene), ca 700 m thick, that are formed of limestones and dolostones. An unconformity divides the Sanya Formation into a Lower Member formed largely of limestones, and an Upper Member formed of dolostones (DI‐8). DI‐8 is separated by a major unconformity into lower (DI‐8L) and upper (DI‐8U) units, that both include numerous subaerial unconformities. The overlying Meishan Formation is a limestone succession that includes three unconformity‐capped dolostones intervals (DI‐5, DI‐6 and DI‐7). Strata below the numerous exposure surfaces throughout the Sanya and Meishan formations are highlighted by Fe‐staining, biomoulds, cavities, caves and solution breccia development. The weakly fabric‐retentive dolostones in DI‐5 to DI‐8 are formed of dolomite crystals that have a dirty core encased by a clear rim, with δ18O values of +0.3 to +4.7‰ (average +2.0‰, n = 50), δ13C values of +2.2 to +3.2‰ (average +2.5‰, n = 50), Fe concentrations of 44 to 442 ppm (average 149 ppm, n = 50), Mn concentrations of 5 to 197 ppm (average 27 ppm, n = 50), Sr concentrations of 169 to 257 ppm (average 218 ppm, n = 50) and 87Sr/86Sr values of 0.70847 to 0.70900 (average 0.70879, n = 32). In all cases, dolomitization post‐dated the subaerial exposure. The 87Sr/86Sr values suggest that the dolostones in DI‐8L formed during the late Early Miocene, whereas the dolostones in DI‐8U, DI‐7, DI‐6 and DI‐5 probably formed simultaneously during the Late Miocene even though these units are stratigraphically hundreds of metres apart and were located well below sea‐level. Dolomitization was preferentially focused in those strata with high porosities and permeabilities that allowed easy circulation of the seawater through the rock. This model suggests that dolomitization was not restricted to strata that were at or close to sea‐level. Although dolomitization may have been related to the new oceanographic circulation regime established during that time, the exact properties of the seawater that promoted dolomitization are open to debate. This model of dolomitization may be applicable to many of the ‘island dolostones’ that are found in the oceans throughout the world.
Analysis of the modern functional field of effective implementation of public control in the system of public administration in Ukraine
Authors: Pukhkal Oleksandr , Reiterovych Ihor , Kuprii Tetiana , Sytnyk Svitlana , Novikov Oleksiy 
Published: March 2023

AbstractThe relevance of this article lies in the fact that the study of the public administration system in Ukraine is an important issue. In modern Ukrainian society there is a clear demand for effective ways to involve the general public and create real mechanisms for implementing democratic principles of public administration through European integration processes. The aim of the study is to analyse the current functional field in the processes of public control in the public administration system of Ukraine. The following research methods were used: analysis and synthesis of information, comparative method, method of sociological research, as well as the method of induction. At the final stage of the study, an analysis of scientific sources on the research topic was carried out. According to the results of the study, it can be argued that the effectiveness of public control in Ukraine directly depends on the state of development of civil society and the level of interaction of its subjects with state authorities and their officials. This largely depends on the motivation of the competent authorities, since state institutions, especially in the legal and organisational spheres, ensure the development of civil society and form the basis for public participation in governance. The practical significance of the research results lies in the fact that the research presented in the article and the analysis of literature sources provides an idea of the implementation of public control in the public administration system in Ukraine, and also opens up new opportunities for its improvement.
On the mechanism of painful burn sensation in tattoos on magnetic resonance imaging (MRI). Magnetic substances in tattoo inks used for permanent makeup (PMU) identified: Magnetite, goethite, and hematite
Authors: Serup Jørgen , Alsing Kasper Køhler , Olsen Ole , Koch Christian Bender , Hansen Rasmus Hvass 
Published: March 2023

AbstractBackgroundPersons with cosmetic tattoos occasionally experience severe pain and burning sensation on magnetic resonance imaging (MRI).ObjectiveTo explore the culprit magnetic substances in commonly used permanent makeup inks.Material and methods20 inks used for cosmetic tattooing of eyebrows, eyeliners, and lips were selected. Ink bottles were tested for magnetic behavior with a neodymium magnet. Eight iron oxide inks qualified for the final study. Metals were analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP‐MS). The magnetic fraction of inks was isolated and analyzed by X‐ray fluorescence (XRF). Magnetic iron compounds were characterized by Mössbauer spectroscopy and powder X‐ray diffraction (XRD).ResultsICP‐MS showed iron in all magnetic samples, and some nickel and chromium. Mössbauer spectroscopy and XRD detected ferromagnetic minerals, particularly magnetite, followed by goethite and hematite.ConclusionThis original study of cosmetic ink stock products made with iron oxide pigments reports magnetic impurities in inks for cosmetic tattooing, e.g., magnetite, goethite, and hematite. These may be the main cause of MRI burn sensation in cosmetic tattoos. The mechanism behind sensations is hypothesized to be induction of electrical stimuli of axons from periaxonal pigment/impurity activated by magnetic force. Magnetite is considered the lead culprit.
Reworking of care during workday outings: On migrant domestic workers' everyday negotiation of migration infrastructure in the global city of Hong Kong
Authors: Chan Henry Hin‐yan 
Published: March 2023

AbstractThis paper examines care as a contested bio‐political arena defining the daily lives of live‐in domestic care migrants in Hong Kong. It asks what roles migration infrastructures and mundane city landscapes play in mediating associated everyday care dynamics. Empirically, it examines two sets of care‐related infrastructures in the city that intimately mediate the population's everyday experience of care. The paper first examines the ways the regulatory infrastructures of the city state, whose operational logics are aligned with the production of 'permanent temporariness' and disposability, systematically deny migrants' access to institutional care for themselves. Second, the papers examine the ways care migrants improvise with the city's situational urban geographies and their human bodies as infrastructure resources during regular work‐bound urban outings to elaborate provisional, localised and informal care infrastructures. While not without challenges, these improvised informal care infrastructures essentially allow the migrant care‐labor population to live with their institu‐tionalised precarity. Overall, the paper makes three contributions. First, it reconceptualises live‐in domestic care migrants as urban actors capable of both navigating and crafting their own care infrastructures in the city, even during workdays. Second, it foregrounds 'care' as an urban and socio‐technical construct in relation to both bio‐political control and interpersonal coping. Third, it employs the ideas of precarity, provisionality and robustness to unpack the bio‐political systems that shape migrants' experiences of care. The findings are based on an analysis of the city's migration regulations and the actual urban work‐life stories of a small group of live‐in domestic care migrants based on participants' personal diaries and interviews with the participants.
Dimer model and holomorphic functions on t‐embeddings of planar graphs
Authors: Chelkak Dmitry , Laslier Benoît , Russkikh Marianna 
Published: March 2023

AbstractWe introduce the framework of discrete holomorphic functions on t‐embeddings of weighted bipartite planar graphs; t‐embeddings also appeared under the name Coulomb gauges in a recent paper (Kenyon, Lam, Ramassamy, and Russkikh, Dimers and circle patterns, 2018). We argue that this framework is particularly relevant for the analysis of scaling limits of the height fluctuations in the corresponding dimer models. In particular, it unifies both Kenyon's interpretation of dimer observables as derivatives of harmonic functions on T‐graphs and the notion of s‐holomorphic functions originated in Smirnov's work on the critical Ising model. We develop an a priori regularity theory for such functions and provide a meta‐theorem on convergence of the height fluctuations to the Gaussian Free Field. We also discuss how several more standard discretizations of complex analysis fit this general framework.
A water transport system across the mantle transition zone beneath western North America as imaged by electrical conductivity data
Authors: Li Shiwen , Li Yabin , Guo Junhao , Zhou Zikun , Weng Aihua 
Published: March 2023

Abstract
The stability field of hydrous phases carried by subducting slabs regulates water transport along the subduction pathway. The ultimate vertical distribution of this water at different depths in Earth’s mantle is governed by the thermal state of the slab. A warm slab is considered to lose water mainly in the upper mantle. However, whether a warm slab can carry water into the lower mantle (LM) is uncertain because of the scarcity of geophysical observations. We report an electrical conductivity model of the mantle transition zone (MTZ) and uppermost LM beneath North America to confirm the water-transporting ability of a warm slab. A high-conductivity anomaly was identified beneath the western United States. The LM portion of this anomaly is interpreted as a hydrous region containing rehydrated stishovite, whereas the lower MTZ portion of the anomaly is ascribed to the presence of water (~0.8 wt%) released by the hydrous stishovite. We speculate that warm slabs, such as the Farallon slab, can cause the breakdown of large amounts of dense hydrous magnesium silicates, releasing water mainly into the upper mantle. This water rehydrates stishovite when percolating through the slab, enabling the slab to continue to transport water into the LM. The identified high-conductivity anomaly, together with previously recognized electrical features in the upper mantle, demonstrates the existence of a trans-MTZ water transport system associated with the warm subduction of the Farallon slab.
Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation
Authors: Sun Yu , Hu Haoran , Liu Zheng , Xu Jian , Gao Yiyun , Zhan Xinyu , Zhou Shun , Zhong Weizhe , Wu Dongming , Wang Ping , Rao Zhuqing , Kong Lianbao , Zhou Haoming 
Published: March 2023

Background and aimsMacrophage innate immune response plays an important role in tumorigenesis. However, the role and mechanism of macrophage STING signaling in modulating tumor microenvironment to suppress tumor growth at secondary sites remains largely unclear.MethodsSTING expression was assessed in liver samples from patients with colorectal cancer (CRC) liver metastasis. Global or myeloid stimulator of interferon gene (STING)-deficient mice, myeloid NOD-like receptor protein 3 (NLRP3)-deficient mice, and wild-type (WT) mice were subjected to a mouse model of CRC liver metastasis by intrasplenic injection of murine colon carcinoma cells (MC38). Liver non-parenchymal cells including macrophages and natural killer (NK) cells were isolated for flow cytometry analysis. Bone marrow-derived macrophages pretreated with MC38 were co-cultured with splenic NK cells for in vitro studies.ResultsSignificant activation of STING signaling were detected in adjacent and tumor tissues and intrahepatic macrophages. Global or myeloid STING-deficient mice had exacerbated CRC liver metastasis and shorten survival, with decreased intrahepatic infiltration and impaired antitumor function of NK cells. Depletion of NK cells in WT animals increased their metastatic burden, while no significant effects were observed in myeloid STING-deficient mice. STING activation contributed to the secretion of interleukin (IL)-18 and IL-1β by macrophages, which optimized antitumor activity of NK cells by promoting the expression of 4-1BBL in macrophages and 4-1BB in NK cells, respectively. Moreover, MC38 treatment activated macrophage NLRP3 signaling, which was inhibited by STING depletion. Myeloid NLRP3 deficiency increased tumor burden and suppressed activation of NK cells. NLRP3 activation by its agonist effectively suppressed CRC liver metastasis in myeloid SITNG-deficient mice.ConclusionsWe demonstrated that STING signaling promoted NLRP3-mediated IL-18 and IL-1β production of macrophages to optimize the antitumor function of NK cells via the co-stimulation signaling of 4-1BBL/4-1BB.
Development and testing of an alternative responder definition for EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI)
Authors: Wratten Samantha , Abetz-Webb Linda , Arenson Ethan , Griffiths Pip , Bowman Simon , Hueber Wolfgang , Ndife Briana , Kuessner Daniel , Goswami Pushpendra 
Published: March 2023

ObjectivesDryness, fatigue and joint/muscle pain are typically assessed in Sjögren’s trials using European Alliance of Associations for Rheumatology Sjögren’s Syndrome Patient Reported Index (ESSPRI). A Patient Acceptable Symptom State of <5 and a Minimal Clinically Important Improvement (MCII)/responder definition (RD) of ≥1 point or 15% on ESSPRI have previously been defined. This study explored alternative RDs to better discriminate between active treatment and placebo in trials.MethodsAnchor-based and distribution-based methods were used to derive RD thresholds in blinded phase IIb trial data (N=190) and confirm these in blinded data pooled from three early phase II trials (N=126). The populations consisted of individuals with moderate-to-severe systemic primary Sjögren’s. Anchors were prioritised by ESSPRI correlations and used in similar conditions. Triangulated estimates were discussed with experts (N=3). The revised RD was compared with the original using unblinded data to assess placebo and treatment responder rates.ResultsPatients were predominantly female (>90%), white (90%), with mean age of 50 years. Receiver operating characteristic estimates supported an MCII threshold of 1.5–1.6 in the phase II data, whereas correlation-weighted mean change estimates supported a low/minimal symptom severity threshold of ≥2. A low/minimal symptom severity of ≤3 showed the greatest sensitivity/specificity balance. Analyses in the pooled data supported these thresholds (MCII: 1.5–2.1; low/minimal symptom severity: 2.7–3.7). Unblinded analyses confirmed the revised RD reduced placebo rates.ConclusionsCompleting a trial with an improvement of ≥1.5 points compared with baseline and an ESSPRI score of ≤3 points is a relevant RD for moderate-to-severe systemic Sjögren’s and reduces placebo rates.
Western Rattlesnake (Crotalus oreganus) spring migration in British Columbia: a comparative study of juveniles and adults
Authors: Howarth Chloe R. , Bishop Christine A. , Larsen Karl W. 
Published: March 2023

In many species, the spatial ecology of early age classes can differ significantly from adults. Adult Western Rattlesnakes ( Crotalus oreganus Holbrook, 1840) at the northern extent of their range undertake small-scale but important seasonal migrations between communal hibernacula and summer foraging and mating grounds. Mature snakes also show annual fidelity to their migratory paths, providing a useful system to examine the development of migratory behaviour. We examined and compared spring outbound migratory movements of juveniles and adults at a site in southern British Columbia, Canada, using radiotelemetry data collected between 2011 and 2016 (adult snakes) and in 2021 (juvenile snakes). We found that compared with adult rattlesnakes, juveniles displayed similar directional orientation, direction of vertical migration, and path sinuosity, but initiated spring migrations later and exhibited shorter movements in terms of distances and rates. For example, juvenile straight-line migration distance (262 ± 90 m) was significantly shorter than that for adults (1069 ± 134 m; P < 0.001). We provide a starting point in attempting to understand an important question in migration—how individuals early on in their lives adopt different tactics—while contributing to our growing understanding of the complexity of patterns and variation in the movement ecology of a far-ranging snake.
NeuroHSMD: Neuromorphic Hybrid Spiking Motion Detector
Authors: Machado Pedro , Ferreira João Filipe , Oikonomou Andreas , McGinnity T. M. 
Published: March 2023

Vertebrate retinas are highly-efficient in processing trivial visual tasks such as detecting moving objects, which still represent complex challenges for modern computers. In vertebrates, the detection of object motion is performed by specialised retinal cells named Object Motion Sensitive Ganglion Cells (OMS-GC). OMS-GC process continuous visual signals and generate spike patterns that are post-processed by the Visual Cortex. Our previous Hybrid Sensitive Motion Detector (HSMD) algorithm was the first hybrid algorithm to enhance Background subtraction (BS) algorithms with a customised 3-layer Spiking Neural Network (SNN) that generates OMS-GC spiking-like responses. In this work, we present a Neuromorphic Hybrid Sensitive Motion Detector (NeuroHSMD) algorithm that accelerates our HSMD algorithm using Field-Programmable Gate Arrays (FPGAs). The NeuroHSMD was compared against the HSMD algorithm, using the same 2012 Change Detection (CDnet2012) and 2014 Change Detection (CDnet2014) benchmark datasets. When tested against the CDnet2012 and CDnet2014 datasets, NeuroHSMD performs object motion detection at 720 × 480 at 28.06 Frames Per Second (fps) and 720 × 480 at 28.71 fps, respectively, with no degradation of quality. Moreover, the NeuroHSMD proposed in this article was completely implemented in Open Computer Language (OpenCL) and therefore is easily replicated in other devices such as Graphical Processing Units (GPUs) and clusters of Central Processing Units (CPUs).
UBE2C-mediated Autophagy Inhibition via Ubiquitination of SIRT1 Contributes to Endometrial Cancer Progression
Authors: Zhao Rong , Liu Yan , Wang Ziwei , Zhang Jun , Zhang Wei , Zhou Xing , Tsedendorj Sevjid , Enkhtur Amarsanaa , Feng Dilu , Wang Hongbo 
Published: March 2023

Abstract

Recent studies have shown that autophagy plays an important role in gynecologic tumors, and ubiquitin modification of autophagy regulatory components is essential to regulate autophagic flux. In this study, we found that the ubiquitin-conjugating enzyme E2C (UBE2C) affects endometrial cancer cell apoptosis and proliferation by inhibiting autophagy. Electron microscopy observation of cell ultrastructure and experimental biochemical analysis showed that endometrial cancer cells with UBE2C expression knocked down display typical autophagic characteristics. Cells were cotreated with the autophagy pharmacologic inhibitors chloroquine and/or bafilomycin A1, and mRFP-GFP-LC3 assays were performed to monitor autophagic flux and determine whether UBE2C suppresses the autophagy program. Investigation of the corresponding mechanism by which UBE2C inhibits autophagy revealed that UBE2C induces K48-linked SIRT1 ubiquitination and promotes ubiquitination-dependent degradation of SIRT1, subsequently reducing H4K16 deacetylation levels and epigenetically inhibiting the expression of autophagy-related genes. The results of cell counting kit-8, Hoechst staining, and immunofluorescence assays further indicated that deletion of the autophagy-related gene BECN1 significantly attenuates UBE2C knockdown–induced cell apoptosis. Moreover, overexpression of UBE2C promoted tumor growth in the xenograft mice model. While, the introduction of rapamycin, an agonist of autophagy, successfully reversed tumor growth and apoptosis inhibition mediated by UBE2C overexpression in vitro and in vivo. Taken together, our results suggested that UBE2C-mediated ubiquitination and degradation of SIRT1 contribute to the malignant progression of endometrial cancer through epigenetic inhibition of autophagy.

Implications:
Our study highlights the tumorigenic role and regulatory mechanism of UBE2C in endometrial cancer; UBE2C inhibits endometrial cancer cell apoptosis through autophagy-related mechanisms and our findings provide new insights into the treatment of endometrial cancer.
Relevant Words Extraction Method for Recommendation System
Authors: Naw Naw , Hlaing Ei Ei 
Published: March 2023

Nowadays, E-commerce is very popular because of information explosion. Text mining is also important for information extraction. Users are more preferable to use the convenience system from many sources such as through web pages, email, social network and so on. This system proposed the relevant words extraction method for car recommendation system from user email. In relevant words extraction, this system proposed the Rule-based approach in Compiling Technique. Context- free grammar is the most suitable for relevant words extraction. Recommendation System (RS) is a most popular tool that helps users to recommend according to their interests. This system implements efficient recommendation system by using proposed key extraction algorithm, Content-based Filtering (CBF) method and Jaccard Coefficient that will help the users who want to buy the car by providing relevant car information.