bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refining the serum miR-371a-3p test for viable germ cell tumor detection
Authors: Lafin John T. , Scarpini Cinzia G. , Amini Armon , Konneh Bendu , Howard Jeffrey M. , Gerald Thomas , Nuno Michelle , Piao Jin , Savelyeva Anna , Wang Zhaohui , Gagan Jeffrey , Jia Liwei , Lewis Cheryl M. , Murray Sarah , Sawa Yun C. , Margulis Vitaly , Woldu Solomon L. , Strand Douglas W. , Coleman Nicholas , Amatruda James F. , Frazier A. Lindsay , Murray Matthew J. , Bagrodia Aditya 
Published: June 2023

AbstractCirculating miR-371a-3p has excellent performance in the detection of viable (non-teratoma) germ cell tumor (GCT) pre-orchiectomy; however, its ability to detect occult disease is understudied. To refine the serum miR-371a-3p assay in the minimal residual disease setting we compared performance of raw (Cq) and normalized (∆Cq, RQ) values from prior assays, and validated interlaboratory concordance by aliquot swapping. Revised assay performance was determined in a cohort of 32 patients suspected of occult retroperitoneal disease. Assay superiority was determined by comparing resulting receiver-operator characteristic (ROC) curves using the Delong method. Pairwise t-tests were used to test for interlaboratory concordance. Performance was comparable when thresholding based on raw Cq vs. normalized values. Interlaboratory concordance of miR-371a-3p was high, but reference genes miR-30b-5p and cel-miR-39-3p were discordant. Introduction of an indeterminate range of Cq 28–35 with a repeat run for any indeterminate improved assay accuracy from 0.84 to 0.92 in a group of patients suspected of occult GCT. We recommend that serum miR-371a-3p test protocols are updated to (a) utilize threshold-based approaches using raw Cq values, (b) continue to include an endogenous (e.g., miR-30b-5p) and exogenous non-human spike-in (e.g., cel-miR-39-3p) microRNA for quality control, and (c) to re-run any sample with an indeterminate result.
Association of different obesity patterns with hypertension in US male adults: a cross-sectional study
Authors: Chen Lu , Zhang Jun , Zhou Nan , Weng Jia-Yi , Bao Zheng-Yang , Wu Li-Da 
Published: June 2023

AbstractObesity is an important risk factor for hypertension. We aimed to investigate the association between different obesity patterns and hypertension risk in a large male population in the US. Male participants from the National Health and Nutrition Examination Survey (NHANES) (2007–2018) were enrolled in this cross-sectional study. Social demographic information, lifestyle factors, anthropometric measurements and biochemical measurements were collected. Three obesity patterns were classified according to the body mass index (BMI) and waist circumference (WC), including overweight and general obesity, abdominal obesity, and compound obesity. We adopted multivariate logistic regression to investigate the associations between hypertension and different obesity patterns after adjusting for cofounding factors. Subgroup analysis, stratified by age, smoking, drinking and estimated glomerular filtration rate (eGFR), was also conducted to explore the associations between obesity patterns and hypertension risk among different populations. Moreover, the association between WC and hypertension among male individuals was also explored using restricted cubic spline (RCS) analysis. Receiver operating characteristic (ROC) was used to evaluate the discriminatory power of WC for screening hypertension risk. 13,859 male participants from NHANES survey (2007–2018) were enrolled. Comparing with the normal-weight group, the odds ratios (ORs) [95% confidence interval (CI)] for hypertension in individuals with overweight and general obesity, abdominal obesity and compound obesity were 1.41 [1.17–1.70], 1.97 [1.53–2.54] and 3.28 [2.70–3.99], respectively. Subgroup analysis showed that the effect of different obesity patterns on hypertension risk was highly stable among individuals with different clinical conditions. In addition, WC had a positive correlation with the risk of hypertension (OR: 1.43; 95% CI 1.37–1.52;P < 0.001) in fully adjusted multivariate logistic regression model. RCS analysis showed that the association between WC and hypertension risk was in a nonlinear pattern, and WC had a good discriminatory power for hypertension in ROC analysis. Different patterns of obesity have a great impact on the risk of hypertension among male individuals. Increment of WC significantly increased the hypertension risk. More attention should be paid to the prevention of obesity, especially abdominal obesity and compound obesity in male individuals.
Prognostic value of coronary CTA-based classifications for predicting major events without obstructive coronary artery disease
Authors: Huang Zengfa , Cao Beibei , Du Xinyu , Li Mei , Huang Jiong , Li Zuoqin , Xiao Jianwei , Wang Xiang 
Published: June 2023

AbstractWe aim to explore the classifications based on coronary computed tomography angiography (CTA) for predicting the risk of major adverse cardiovascular events (MACE) in patients with suspected non-obstructive coronary artery disease (CAD) and compare with traditional non-obstructive CAD (NOCAD) classification, Duke prognostic NOCAD index, Non-obstructive coronary artery disease reporting and data system (NOCAD-RADS). 4378 consecutive non-obstructive CAD patients were assessed by coronary CTA for traditional NOCAD classification, Duke prognostic NOCAD index, NOCAD-RADS and a new classification (stenosis proximal involvement, SPI) from two medical centrals. We defined proximal involvement as any plaque was present in the main or proximal segments of coronary artery (left main, left anterior descending artery, left circumflex artery, or right coronary artery). The main outcome was MACE. During a median follow-up of 3.7 years, a total of 310 patients experienced MACE event. Kaplan–Meier survival curves showed the cumulative events increased significantly associated with traditional NOCAD, Duke NOCAD index, NOCAD-RADS and SPI classifications (all P < 0.001). In multivariate Cox regressions, the risk for the events increased from HR 1.20 (95% CI 0.78–1.83, P = 0.408) for SPI 1 to 1.35 (95% CI 1.05–1.73, P = 0.019) for SPI 2, using SPI 0 as the reference group. Coronary CTA based SPI classification provided important prognostic information for all cause-mortality risk and MACE prediction in patients with non-obstructive CAD, which was non-inferior than traditional NOCAD, Duke NOCAD Index and NOCAD-RADS classifications. The plaque location information by coronary CTA may provide additional risk prediction in patients with non-obstructive CAD.
Pure edge-contact devices on single-layer-CVD-graphene integrated into a single chip
Authors: Behera Saraswati 
Published: June 2023

AbstractWe present a simple and cost-effective fabrication technique for on-chip integration of pure edge contact two-terminal (2T) and Graphene field effect transistor (GFET) devices with low contact resistance and nonlinear characteristics based on single-layer chemical-vapor-deposited (CVD) graphene. We use a smart print-based mask projection technique with a 10X magnification objective lens for maskless lithography followed by thermal evaporation of the contact material Cr-Pd-Au through three different angles (90° and ± 45°) using a customized inclined-angle sample-holder to control the angle during normal incidence evaporation for edge-contact to graphene. Our fabrication technique, graphene quality, and contact geometry enable pure metal contact to 2D single-layer graphene allowing electron transport through the 1D atomic edge of graphene. Our devices show some signatures of edge contact to graphene in terms of very low contact resistance of 23.5 Ω, the sheet resistance of 11.5 Ω, and sharp nonlinear voltage-current characteristics (VCC) which are highly sensitive to the bias voltage. This study may find application in future graphene-integrated chip-scale passive or active low-power electronic devices.
Adsorption and reversible conformational change of a thiophene based molecule on Au(111)
Authors: Sarkar Suchetana , Au-Yeung Kwan Ho , Kühne Tim , Waentig Albrecht , Ryndyk Dmitry A. , Heine Thomas , Cuniberti Gianaurelio , Feng Xinliang , Moresco Francesca 
Published: June 2023

AbstractWe present a low temperature scanning tunneling microscope investigation of a prochiral thiophene-based molecule that self-assembles forming islands with different domains on the Au(111) surface. In the domains, two different conformations of the single molecule are observed, depending on a slight rotation of two adjacent bromothiophene groups. Using voltage pulses from the tip, single molecules can be switched between the two conformations. The electronic states have been measured with scanning tunneling spectroscopy, showing that the electronic resonances are mainly localized at the same positions in both conformations. Density-functional theory calculations support the experimental results. Furthermore, we observe that on Ag(111), only one configuration is present and therefore the switching effect is suppressed.
ConvNeXt steel slag sand substitution rate detection method incorporating attention mechanism
Authors: Teng Shengjie , Zhu Lin , Li Yunze , Wang Xinnian , Jin Qiang 
Published: June 2023

AbstractThe proportion of natural sand replaced by steel slag sand affects the volumetric stability of steel slag mortar and steel slag concrete. However, the steel slag substitution rate detection method is inefficient and lacks representative sampling. Therefore, a deep learning-based steel slag sand substitution rate detection method is proposed. The technique adds a squeeze and excitation (SE) attention mechanism to the ConvNeXt model to improve the model's efficiency in extracting the color features of steel slag sand mix. Meanwhile, the model's accuracy is further enhanced by using the migration learning method. The experimental results show that SE can effectively help ConvNeXt acquire images' color features. The model's accuracy in predicting the replacement rate of steel slag sand is 87.99%, which is better than the original ConvNeXt network and other standard convolutional neural networks. After using the migration learning training method, the model predicts the steel slag sand substitution rate with 92.64% accuracy, improving accuracy by 4.65%. The SE attention mechanism and the migration learning training method can help the model acquire the critical features of the image better and effectively improve the model's accuracy. The method proposed in this paper can identify the steel slag sand substitution rate quickly and accurately and can be used for the detection of the steel slag sand substitution rate.
A cross-country analysis of sustainability, transport and energy poverty
Authors: Furszyfer Del Rio Dylan D. , Sovacool Benjamin K. , Griffiths Steve , Foley Aoife M. , Furszyfer Del Rio Jonathan 
Published: June 2023

AbstractPoverty impacts people’s choices and opportunities and can perpetuate a disadvantaged status. Poverty remains a prevalent global issue due to disproportionate wealth distribution, which often translates to inequality in energy consumption and emissions. This research investigates if low-income households and minorities from four countries with very different national cultures, contexts, and levels of wealth experience a ‘double energy vulnerability’, a concept that simultaneously positions people at heightened risk of transport and energy poverty. Our research identifies that low-income households and minorities are at higher risk of simultaneously experiencing energy and transport poverty regardless of the national context in which they live. Our study also contests the achievement of Sustainable Development Goals (SDGs) by 2030, showing that even in relatively wealthy countries, many individuals still face energy and transport poverty. We conclude that global sustainable development requires significant shifts in policy action, resource distribution and investment in social services.
Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition
Authors: Sjöland Wilhelm , Wahlström Annika , Makki Kassem , Schöler Marc , Molinaro Antonio , Olsson Lisa , Greiner Thomas Uwe , Caesar Robert , de Boer Jan Freark , Kuipers Folkert , Bäckhed Fredrik , Marschall Hanns-Ulrich 
Published: June 2023

Abstract
Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age- and sex-dependent signs of hepatobiliary disease and can be used as a model to study interactions between bile acids and the gut microbiota in cholestatic liver disease. In the present study, we rederived Cyp2c70−/− mice as germ-free (GF) and colonized them with a human or a mouse microbiota to investigate whether the presence of a microbiota can be protective in cholangiopathic liver disease associated with Cyp2c70-deficiency. GF Cyp2c70−/− mice showed reduced neonatal survival, liver fibrosis, and distinct cholangiocyte proliferation. Colonization of germ-free breeding pairs with a human or a mouse microbiota normalized neonatal survival of the offspring, and particularly colonization with mouse microbiota from a conventionally raised mouse improved the liver phenotype at 6–10 weeks of age. The improved liver phenotype in conventionalized (CD) Cyp2c70−/− mice was associated with increased levels of tauro-ursodeoxycholic acid (TUDCA) and UDCA, resulting in a more hydrophilic bile acid profile compared with GF and humanized Cyp2c70−/− mice. The hydrophobicity index of biliary bile acids of CD Cyp2c70−/− mice was associated with changes in gut microbiota, liver weight, liver transaminases, and liver fibrosis. Hence, our results indicate that neonatal survival of Cyp2c70−/− mice seems to depend on the establishment of a gut microbiota at birth, and the improved liver phenotype in CD Cyp2c70−/− mice may be mediated by a larger proportion of TUDCA/UDCA in the circulating bile acid pool and/or by the presence of specific bacteria.
Seleção de enxerto entre autoenxerto e aloenxerto de tendão na reconstrução do ligamento cruzado anterior com base na perspectiva histológica: uma metanálise
Authors: Setiawan Celleen Rei , Aryana I Gusti Ngurah Wien 
Published: June 2023

Resumo
Objetivo: O objetivo desta metanálise é comparar a cicatrização de ligamentos no autoenxerto e aloenxerto na reconstrução do ligamento cruzado anterior (LCA).
Métodos: A seleção dos estudos adequados foi realizada de acordo com as diretrizes de Relatórios Preferenciais para Revisões Sistemáticas e Metanálises (Preferred Reporting Items for Systematic Reviews and Meta-Analyses – PRISMA). Uma análise estatística foi feita usando um gerente de revisão. Os relatórios eletrônicos foram pesquisados usando os bancos de dados PubMed, Medline e Cochrane Library. Os critérios de inclusão foram estudos em animais e a histologia celular de ambos os enxertos como desfecho.
Resultado: A pesquisa inicial revelou 412 artigos potenciais. Após a retirada das duplicatas, restaram 246 artigos. Então, 14 artigos foram obtidos e selecionados pela relevância e elegibilidade. Os artigos relevantes foram pesquisados manualmente, verificando sua elegibilidade e detalhando os estudos para não perder os relatórios incluídos. Posteriormente, foram incluídos 5 estudos, com um total de 232 amostras, relatando os resultados de biópsia com histologia quantitativa de cicatrização de ligamento entre aloenxerto e autoenxerto. As amostras de biópsia nesses estudos foram examinadas sob microscópio leve ou eletrônico, para análise da área de distribuição celular e estágios de ligamentização em cada grupo. As metanálises encontraram diferença significativa entre autoenxerto e aloenxerto (Heterogeneidade, I2 = 89%; Diferença média, 95% intervalo de confiança [IC] = −34,92, −54,90, −14,93; p = 0,0006). Também há uma diferença significativa nos dois enxertos na contagem celular de mais de 24 semanas (Heterogeneidade, I2 = 26%; Diferença média, 95% IC = −14,59 , −16,24, −12,94; p < 0,00001).
Conclusão: Na presente metanálise, o autoenxerto mostra resultados significativos quando comparado ao aloenxerto, com mais acúmulo celular e resposta de remodelagem mais rápida no processo de ligamentização sendo observado no primeiro. No entanto, será necessário um estudo clínico maior para enfatizar o resultado desta literatura.
Management of Generalised Anxiety Disorder through Individualised Homoeopathic Medicine: A Case Study
Authors: Khadim Azizul Islam 
Published: June 2023

Abstract
Background Anxiety disorder is the most common psychological problem in this modern era. It is characterised by cognitive, somatic, emotional and behavioural components. Anxiety can affect the quality of life of an individual and can interfere with a person's career, academics, job, family and social life. Owing to the prolonged side effects from conventional medication, patients turn towards homoeopathy for safe, gentle and effective treatment.
Method A 23-year-old male diagnosed with generalised anxiety disorder (GAD) came to outpatient department after having consulted other physicians without benefit. The patient received individualised homoeopathic medicine. Outcome was measured using the GAD-7 every 3 months.
Results At the start of the treatment, the patient's GAD-7 score was 16 which reflected severe anxiety. After 9 months, it was reduced to 2.
Conclusion This case demonstrates the utility of individualised homoeopathic treatment in improving GAD within 9 months of treatment. Nevertheless, large sample randomised controlled study would be required to support this single case observation.
Mieloma Múltiplo (Parte 1) – Atualização Sobre Epidemiologia, Critérios Diagnósticos, Tratamento Sistêmico e Prognóstico
Authors: Guedes Alex , Becker Ricardo Gehrke , Teixeira Luiz Eduardo Moreira 
Published: June 2023

ResumoO mieloma múltiplo (MM) constitui neoplasia maligna de origem hematológica caracterizada pela proliferação desregulada e clonal de plasmócitos na medula óssea; estas células produzem e secretam imunoglobulina monoclonal anômala, ou um fragmento desta, denominado proteína M. As manifestações clínicas do MM decorrem da proliferação destes plasmócitos, da produção excessiva de imunoglobulina monoclonal e da supressão da imunidade humoral normal, levando à hipercalcemia, destruição óssea, insuficiência renal, supressão da hematopoiese e da imunidade humoral, aumentando o risco para o desenvolvimento de infecções. O aumento na expectativa de vida da população mundial levou a concomitante incremento na prevalência do MM, patologia que habitualmente acomete a população idosa. O objetivo desta revisão é atualizar o leitor sobre a epidemiologia, critérios diagnósticos, diagnóstico diferencial com outras gamopatias monoclonais, tratamento sistêmico e prognóstico do MM.
Rhetorical (ir)responsibility in the Australian Parliament
Authors: McLaughlin Simon , Weder Franzisca 
Published: June 2023

Abstract
In this conceptual paper, we differentiate between political decisions and the conversations where these decisions
are discussed and facilitated. We complement existing work on argumentation in political communication by applying Aristotle’s
Rhetoric to the study of climate change debate. We show how Aristotle’s principles for ethical and rational
political speech work toward audience trust and encourage deliberative debate and decision-making. Our deliberative perspective is
supported by a case study analysis of Australia’s parliamentary climate change debate. We resurrect Aristotle’s
Rhetoric both as an analytical tool for critical analysis and a potential framework for constructive climate
change debate. Following the conceptualisation of parliamentary debate as a conversational space where decision-making processes
are facilitated, we introduce Aristotle’s Rhetoric and the concept of ‘rhetorical responsibility’, which is
further explored and exemplified in the case study. We conclude with future research questions for discourse and political
communication studies.
Design of an active detection system for ice and snow pollutants and freezing temperature on runway
Authors: Chen Bin , Gao Darui , Yang Junhai , Li Zongshuai 
Published: June 2023

Abstract
This paper studied the problem of ice and snow pollutants identification and freezing temperature detection under winter runway operation, and designed an active detection system for runway ice and snow pollutants and freezing temperature. The temperature change trend during the liquid freezing process was researched, and the freezing temperature detection model based on sequence segmented linear fitting and inflection point identification was proposed in combination with active cooling technology. The differences in dielectric properties of runway snow and ice cover are studied, and a multi-frequency detection-based forked-finger planar capacitive sensor was identified for snow and ice pollutants detection considering practical application scenarios. A finite element simulation model of the forked-finger planar capacitive sensor was established, to optimize the structural parameters of the sensor and verify the feasibility of the capacitor sensor. Finally, the detection device and control system were designed and fabricated, and built an experimental platform for system test. The field experimental results showed that the system has good reliability and stability, and the error of freezing temperature detection model is less than 0.3 °C. At the same time, it can identify three types of pollutants, including water, ice and ice–water mixture, with an accuracy of 89%.
A novel magnetic calibration method based on an extended shaping filter
Authors: Ma Xiaoyu , Zhang Jinsheng , Li Ting 
Published: June 2023

Abstract
During maneuvering of high-speed aircraft, the eddy-current magnetic field has a significant impact on the real-time geomagnetic field measurement accuracy. However, it is difficult to estimate the eddy-current component directly when it is considered in the magnetic distortion model. In this paper, we proposed a geomagnetic field estimation method based on a shaping filter. Soft-iron, hard-iron and eddy-current field distortions were considered in the compensation system. In the estimation process, a higher-order shaping filter is designed to coincide the higher-order statistics of the alternative system with the input of the original system. Simulation results showed that our proposed method could accurately estimate the eddy-current field. Compared with methods that do not consider the eddy-current field, the root-mean-square error of the geomagnetic field could be reduced by more than 50%, thus significantly improving the accuracy of geomagnetic field measurement.