bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer
Authors: Sandhya Lakshmi , Devi Sreenivasan Nirmala , Goenka Luxitaa , Dubashi Biswajit , Kayal Smita , Solaiappan Manikandan , Govindarajalou Ramkumar , KT Harichandrakumar , Ganesan Prasanth 
Published: March 2023

PURPOSE Anorexia occurs in 30%-80% of patients with advanced malignancies, which may be worsened with chemotherapy. This trial assessed the efficacy of olanzapine in stimulating appetite and improving weight gain in patients receiving chemotherapy. METHODS Adults (≥18 years) with untreated, locally advanced, or metastatic gastric, hepatopancreaticobiliary (HPB), and lung cancers were randomly assigned (double-blind) to receive olanzapine (2.5 mg once a day for 12 weeks) or placebo along with chemotherapy. Both groups received standard nutritional assessment and dietary advice. The primary outcomes were the proportion of patients with weight gain > 5% and the improvement in appetite (assessed by the visual analog scale [VAS] and the Functional Assessment of Chronic Illness Therapy system of Quality-of-Life questionnaires Anorexia Cachexia subscale [FAACT ACS]). Secondary end points were change in nutritional status, quality of life (QOL), and chemotherapy toxicity. RESULTS We enrolled 124 patients (olanzapine, 63 and placebo, 61) with a median age of 55 years (18-78 years), of whom 112 (olanzapine, 58 and placebo, 54) were analyzable. The majority (n = 99, 80%) had metastatic cancer (gastric [n = 68, 55%] > lung [n = 43, 35%] > HPB [n = 13, 10%]). The olanzapine arm had a greater proportion of patients with a weight gain of > 5% (35 of 58 [60%] v 5 of 54 [9%], P < .001) and improvement in appetite by VAS (25 of 58 [43%] v 7 of 54 [13%], P < .001) and by FAACT ACS (scores ≥37:13 of 58 [22%] v 2 of 54 [4%], P = .004). Patients on olanzapine had better QOL, nutritional status, and lesser chemotoxicity. Side effects attributable to olanzapine were minimal. CONCLUSION Low-dose, daily olanzapine is a simple, inexpensive, well-tolerated intervention that significantly improves appetite and weight gain in newly diagnosed patients on chemotherapy.
Randomized Phase III Study of Enzalutamide Compared With Enzalutamide Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer (Alliance A031201 Trial)
Authors: Morris Michael J. , Heller Glenn , Hillman David W. , Bobek Olivia , Ryan Charles , Antonarakis Emmanuel S. , Bryce Alan H. , Hahn Olwen , Beltran Himisha , Armstrong Andrew J. , Schwartz Lawrence , Lewis Lionel D. , Beumer Jan H. , Langevin Brooke , McGary Eric C. , Mehan Paul T. , Goldkorn Amir , Roth Bruce J. , Xiao Han , Watt Colleen , Taplin Mary-Ellen , Halabi Susan , Small Eric J. 
Published: March 2023

PURPOSE Enzalutamide and abiraterone both target androgen receptor signaling but via different mechanisms. The mechanism of action of one drug may counteract the resistance pathways of the other. We sought to determine whether the addition of abiraterone acetate and prednisone (AAP) to enzalutamide prolongs overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the first-line setting. PATIENTS AND METHODS Men with untreated mCRPC were randomly assigned (1:1) to receive first-line enzalutamide with or without AAP. The primary end point was OS. Toxicity, prostate-specific antigen declines, pharmacokinetics, and radiographic progression-free survival (rPFS) were also examined. Data were analyzed using an intent-to-treat approach. The Kaplan-Meier estimate and the stratified log-rank statistic were used to compare OS between treatments. RESULTS In total, 1,311 patients were randomly assigned: 657 to enzalutamide and 654 to enzalutamide plus AAP. OS was not statistically different between the two arms (median, 32.7 [95% CI, 30.5 to 35.4] months for enzalutamide v 34.2 [95% CI, 31.4 to 37.3] months for enzalutamide and AAP; hazard ratio [HR], 0.89; one-sided P = .03; boundary nominal significance level = .02). rPFS was longer in the combination arm (median rPFS, 21.3 [95% CI, 19.4 to 22.9] months for enzalutamide v 24.3 [95% CI, 22.3 to 26.7] months for enzalutamide and AAP; HR, 0.86; two-sided P = .02). However, pharmacokinetic clearance of abiraterone was 2.2- to 2.9-fold higher when administered with enzalutamide, compared with clearance values for abiraterone alone. CONCLUSION The addition of AAP to enzalutamide for first-line treatment of mCRPC was not associated with a statistically significant benefit in OS. Drug-drug interactions between the two agents resulting in increased abiraterone clearance may partly account for this result, although these interactions did not prevent the combination regimen from having more nonhematologic toxicity.
Two Aspects of Language, Two Types of Comparison
Authors: Hutchinson Ben 
Published: March 2023

AbstractThis article revisits the emergence of “comparative” and “world” literature within the early nineteenth century, arguing that we can only understand the full normative force of the two terms if we read them rhetorically. In order to do this, the article draws on Roman Jakobson’s classic essay “Two Aspects of Language and Two Types of Aphasic Disturbances” (1956). Jakobson makes a number of claims in this essay, the most celebrated of which is his distinction between the two poles of “metaphoric” and “metonymic” language. The motor of metaphor, Jakobson reminds us, is similarity (one thing is like another); the motor of metonymy, on the other hand, is contiguity (one thing is next to, or part of another). Jakobson’s distinction, this article suggests, maps instructively onto the mechanisms of comparative and world literature: where the former compares one text to another, the latter situates one text within the global field of others. For comparison to be possible, initially, the things being compared must stand apart; to claim the status of world literature for a given work, conversely, is to make it part of a broader whole. Comparative and world literature may thus be said to function as a mobile army of metaphors and metonymies.
Wikipedia's Race and Ethnicity Gap and the Unverifiability of Whiteness
Authors: Mandiberg Michael 
Published: March 2023

AbstractAlthough Wikipedia has a widely studied gender gap, almost no research has attempted to discover if it has a comparable race and ethnicity gap among its editors or its articles. No such comprehensive analysis of Wikipedia's editors exists because legal, cultural, and social structures complicate surveying them about race and ethnicity. Nor is it possible to precisely measure how many of Wikipedia's biographies are about people from indigenous and nondominant ethnic groups, because most articles lack ethnicity information. While it seems that many of these uncategorized biographies are about white people, these biographies are not categorized by ethnicity because policies require reliable sources to do so. These sources do not exist for white people because whiteness is a social construct that has historically been treated as a transparent default. Thus, these biographies cannot be categorized as white because whiteness is unverifiable in Wikipedia's white epistemology. In the absence of a precise analysis of the gaps in its editors or its articles, I present a quantitative and qualitative analysis of these structures that prevent such an analysis. I examine policy discussions about categorization by race and ethnicity, demonstrating persistent anti-Black racism. Turning to Wikidata, I reveal how the ontology of whiteness shifts as it enters the database, functioning differently than existing theories of whiteness account for. While the data does point toward a significant race and ethnicity gap, the data cannot definitively reveal meaning beyond its inability to reveal quantitative meaning. Yet the unverifiability of whiteness is itself an undeniable verification of Wikipedia's whiteness.
Recovery from COVID-19 in Adult Recreational Athletes: A Survey of American Triathletes
Authors: Schroeder Allison N. , Getzin Andrew R. , Creswell Lawrence L. , Asplund Chad A. 
Published: March 2023

ABSTRACT

Introduction/Purpose
Little is currently known regarding coronavirus disease 2019 (COVID-19) symptomatology and return to exercise, training, and fitness after COVID-19 in adult recreational athletes. The purpose of this study was to determine which COVID-19-related symptoms are associated with prolonged return to sport in U.S. triathletes.

Methods
This was an online survey cohort study of USA Triathlon members (104 participants). Self-reported participant demographics, comorbid conditions, symptoms, and complications experienced with COVID-19 were assessed. Time required for the athlete to return to exercise, training, and normal fitness and whether symptoms worsened upon return to training were determined.

Results
Survey respondents were predominantly male (average age, 44.5 ± 1.9 yr) and healthy at baseline (91.0% had no risk factors for COVID-19 and 76.9% had no potential risk factors). After COVID-19, 50% of athletes returned to exercise in <1 wk, 30% returned to training in <1 wk, and 39% returned to normal fitness in <1 month. Thirty-five athletes (33.7%) felt worse upon return to training. Return to training took >14 d in more than 50% of athletes, and only 13% took >8 wk to return to normal fitness. Fever, shortness of breath, fatigue, and headache were all associated with prolonged return to exercise, training, and fitness (all P < 0.05).

Conclusions
Triathletes with COVID-19 who experienced fever, shortness of breath, headache, and fatigue should be counseled that they may have a more prolonged return to exercise, training, and normal fitness compared with those with less severe symptoms.
Malaria: an update for nurses in general practice
Authors: Grieve Sandra 
Published: March 2023

Malaria is a mosquito-borne, potentially fatal disease that is distributed throughout the tropics. Malaria is caused by the parasite Plasmodium, transmitted to humans by the bite of a female Anopheles mosquito, most active between dusk and dawn. Insect bite avoidance is crucial to prevent bites from infected mosquitoes causing infection. All travellers visiting malaria endemic areas are at risk of exposure. Conducting a pre-travel risk assessment and providing appropriate advice to the individual is essential. The malaria prevention guidance emphasises that effective bite prevention should be the first line of defence against malaria infection, even when chemoprophylaxis is used. Recommendations for antimalarials should be appropriate for the destination, tailored to the individual, and account for the risks and benefits to the traveller. Malaria is a preventable, but potentially fatal illness. Sandra Grieve provides an update for those providing travel consultations in general practice
The Right to Science: Centering People With Intellectual Disability in the Process and Outcomes of Science
Authors: Shogren Karrie A. 
Published: March 2023

Abstract
The right to science has been identified in multiple human rights treaties; however, there has not been a clear framework for how governments or research organizations can advance this right particularly ensuring equitable engagement of people with intellectual disability (ID) in the process of scientific research. Although the feasibility and impacts of engaging people with ID in the process of science have been repeatedly demonstrated there remain systemic barriers including ableism, racism, and other systems of oppression that sustain inequities. Researchers in the ID field must take steps to dismantle systemic barriers and advance participatory approaches that advance equity in the process and outcomes of science.
Utopia for Norwegian helicopter emergency medical services: Estimating the number of bases needed to radically bring down response times, and lives needed to be saved for cost effectiveness
Authors: Jagtenberg Caroline Jeanne , Uleberg Oddvar , Waaler Bjørnelv Gudrun Maria , Røislien Jo 
Published: March 2023

ObjectivesHelicopter Emergency Medical Services (HEMS) throughout Europe are generally on scene within 10–15 minutes. In Norway, however, with its 13 HEMS bases, only 75% of the population can currently be reached within half an hour. We estimate the number of HEMS bases needed to reach the full Norwegian population within 10–15 minutes, and discuss implications regarding cost effectiveness.MethodsUsing geographic location and population characteristics from Norway’s 428 municipalities as input to the Maximal Covering Location Problem–a mathematical location optimization model–we estimate the number of HEMS bases required along with accompanying personnel and healthcare costs. We estimate the minimum number of lives that would have to be saved to achieve a net social benefit of zero.ResultsTo reach 99% or 100% of the Norwegian population by HEMS within 15 minutes 78 or 104 bases are needed, respectively. The incremental need for personnel going from 20 to 15 minutes for 99/100% of the population is 602/728, with an accompanying incremental cost of 228/276 million EURO per year. A yearly total of 280/339 additional lives would have to be saved to obtain a net social benefit of zero. Then, the HEMS-system as a whole would be cost effective although the least efficient bases still would not be.ConclusionsReducing Norwegian HEMS response times to 10–15 minutes requires a drastic increase in the number of HEMS bases needed. Choice of ethical philosophy (utilitarianism or egalitarianism) determines when the expansion might be considered cost effective.
Therapeutic effect and mechanism of Daikenchuto in a model of methotrexate-induced acute small intestinal mucositis
Authors: Li Peilin , Inoue Yusuke , Miyamoto Daisuke , Adachi Toshiyuki , Okada Satomi , Adachi Tomohiko , Soyama Akihiko , Hidaka Masaaki , Kanetaka Kengo , Ito Shinichiro , Sadatomi Daichi , Mogami Sachiko , Fujitsuka Naoki , Gu Weili , Eguchi Susumu 
Published: March 2023

Background
Daikenchuto (DKT) has positive therapeutic effects on improving various gastrointestinal disorders. The present study investigated whether or not DKT has a potential therapeutic effect on chemotherapy-induced acute small intestinal mucositis (CIM) in a rat model.

Methods
Intraperitoneal injection of 10 mg/kg methotrexate (MTX) every 3 days for a total of 3 doses was used for induction of CIM in a rat model. The MTX and DKT-MTX groups were injected with MTX as above from the first day, and the DKT-MTX and DKT groups were administered 2.7% DKT via the diet at the same time. The rats were euthanized on day 15.

Results
The DKT-MTX group showed an improvement in the body weight and conditions of gastrointestinal disorders as well as increased levels of diamine oxidase in plasma and in the small intestinal villi. The pathology results showed that small intestinal mucosal injury in the DKT-MTX group was less severe than that in the MTX group. Immunohistochemistry for myeloperoxidase and malondialdehyde and quantitative real-time polymerase chain reaction (RT-qPCR) for TGF-β1 and HIF-1α showed that DKT attenuated peroxidative damage. The crypts in the DKT-MTX group contained more Ki-67-positive cells than MTX group. The zonula occluden-1 and claudin-3 results showed that DKT promoted repair of the mucosal barrier. RT-qPCR for the amino acid transporters EAAT3 and BO+AT also confirmed that DKT promoted mucosal repair and thus promoted nutrient absorption.

Conclusion
DKT protected against MTX-induced CIM in a rat model by reducing inflammation, stimulating cell proliferation, and stabilizing the mucosal barrier.
In Vitro effects of petroleum ether, dichloromethane, methanolic and aqueous leaf extracts of Eucalyptus grandis on selected multidrug-resistant bacteria
Authors: Kwansa-Bentum Bethel , Okine Beatrice Awuradwoa , Dayie Alberta D. , Tetteh-Quarcoo Patience B. , Kotey Fleischer C. N. , Donkor Eric S. , Dayie Nicholas T. K. D. 
Published: March 2023

BackgroundThe emergence and spread of antimicrobial resistance is of grave concern, requiring the search for newer and more effective antimicrobials to combat infections caused by resistant microbes. This study assessed the antimicrobial effects ofEucalyptus grandiscrude extracts against selected multidrug resistant bacteria.MethodologyFour different crude leaf extracts ofE.grandiswere prepared using petroleum ether, dichloromethane, methanol, and water, with the aid of the Soxhlet extraction method. These were screened against methicillin-resistantStaphylococcus aureus(MRSA), multidrug resistantPseudomonas aeruginosa, and multidrug resistantEscherichia coli, using the agar well diffusion method. Phytochemical screening was carried out to evaluate the bioactive phytochemical constituents responsible for the antimicrobial effect.ResultsEach of the extracts, except for the one prepared from water, had antimicrobial activity against the screened bacteria. The non-polar petroleum ether extract had the highest antimicrobial activity (19.33–24.33 mm), including bactericidal effects, compared to the medium polar dichloromethane and polar methanol extracts, which recorded zone diameter ranges of 14.33–16.67 mm and 16.33–17.67 mm, respectively. The Gram-negative bacteria (E.coliandP.aeruginosa) were the least susceptible in comparison with the Gram-positive bacterium (MRSA), probably owing to differences in their cell wall structures. Furthermore, phytochemical screening indicated the presence of alkaloids, tannins, saponins, terpenoids, and flavonoids.ConclusionThe findings suggest thatE.grandiscould be potentially useful in the treatment of infections caused by multidrug resistant bacteria.
Clinical characteristics and factors associated with COVID-19-related mortality and hospital admission during the first two epidemic waves in 5 rural provinces in Indonesia: A retrospective cohort study
Authors: Surendra Henry , Praptiningsih C. Yekti , Ersanti Arina M. , Rahmat Mariati , Noviyanti Widia , Harmani Joshua A. D. , Mansur Erni N. A. , Suleman Yana Y. , Sudrani Sitti , Rosalina Rosalina , Mukhtar Ismen , Rosadi Dian , Fauzi Lukman , Elyazar Iqbal R. F. , Hawley William A. , Wibisono Hariadi 
Published: March 2023

Background
Data on coronavirus disease 2019 (COVID-19) clinical characteristics and severity from resource-limited settings are limited. This study examined clinical characteristics and factors associated with COVID-19 mortality and hospitalisation in rural settings of Indonesia, from 1 January to 31 July, 2021.

Methods
This retrospective cohort included individuals diagnosed with COVID-19 based on polymerase chain reaction or rapid antigen diagnostic test, from five rural provinces in Indonesia. We extracted demographic and clinical data, including hospitalisation and mortality from a new piloted COVID-19 information system named Sistem Informasi Surveilans Epidemiologi (SISUGI). We used mixed-effect logistic regression to examine factors associated with COVID-19-related mortality and hospitalisation.

Results
Of 6,583 confirmed cases, 205 (3.1%) died and 1,727 (26.2%) were hospitalised. The median age was 37 years (Interquartile range 26–51), with 825 (12.6%) under 20 years, and 3,371 (51.2%) females. Most cases were symptomatic (4,533; 68.9%); 319 (4.9%) had a clinical diagnosis of pneumonia and 945 (14.3%) presented with at least one pre-existing comorbidity. Age-specific mortality rates were 0.9% (2/215) for 0–4 years; 0% (0/112) for 5–9 years; 0% (1/498) for 10–19 years; 0.8% (11/1,385) for 20–29 years; 0.9% (12/1,382) for 30–39 years; 2.1% (23/1,095) for 40–49 years; 5.4% (57/1,064) for 50–59 years; 10.8% (62/576) for 60–69 years; 15.9% (37/232) for ≥70 years. Older age, pre-existing diabetes, chronic kidney disease, liver diseases, malignancy, and pneumonia were associated with higher risk of mortality and hospitalisation. Pre-existing hypertension, cardiac diseases, COPD, and immunocompromised condition were associated with risk of hospitalisation but not with mortality. There was no association between province-level density of healthcare workers with mortality and hospitalisation.

Conclusion
The risk of COVID-19-related mortality and hospitalisation was associated with higher age, pre-existing chronic comorbidities, and clinical pneumonia. The findings highlight the need for prioritising enhanced context-specific public health action to reduce mortality and hospitalisation risk among older and comorbid rural populations.
Structural and Luminescence Analysis of Low Temperature Solution Combustion Derived White Light Emitting Y2(1-x)Dy2xZr2O7 Nanophosphors for WLEDs
Authors: Singh Sonika , Dalal Annu , Kumar Mahesh , Dhaterwal Deepika 
Published: March 2023

White light emitting dysprosium doped rare-earth zirconate Y2(1-x)Dy2xZr2O7 (x = 0.5 to 5 mol%) crystalline phosphors in nano-regime were obtained using urea supported solution combustion methodology at low temperature 650 ºC. Presence of fluorite structure having cubic symmetry with Fm3m space group was analyzed by powder X-ray diffraction patterns. Spherical shaped nanoparticles with clear boundaries were observed by surface morphological studies. Diverse elements Y, Zr, Dy and O were present in the optimized nanophosphors as examined by energy dispersive X-ray analysis. Upon near ultraviolet (NUV) excitation at 354 nm wavelength, the Y2(1-x)Dy2xZr2O7 phosphors displayed the characteristic white light emanation resulted from blue and yellow emission owing to 4F9/2→6H15/2 (450-525 nm) and 4F9/2→6H13/2 (525-650) transitions, respectively. With the doping of 1.5 mol% amount of Dy3+ ions in Y2(1-x)Dy2xZr2O7 powders showed maximum photoluminescence emission, above which intensity was quenched due to dipole-dipole interactions. In addition, Y1.97Dy0.03Zr2O7 nanopowders exhibit CIE colour coordinates (0.2605, 0.3145) residing in white region. The closeness of this value to the white emission coordinates of the National Television System Committee (NTSC) endorsed Y2(1-x)Dy2xZr2O7 nanophosphors as fascinating candidate for displays and white light emitting diodes.
An Uncommon Case of Urethral Leiomyoma in a Female
Authors: Sajira Bhasi  , Yogesh Bhandari  , Munir Sayed  , Sanket Shah  , Subbian Krishnamurthy  
Published: March 2023

Rare sites of myoma can present with unusual symptoms, which can cause clinical dilemmas in management. Leiomyomas are benign mesenchymal tumours which arise from smooth muscles. They are commonly found in the uterus. Leiomyoma in the vagina and urethra are a rare occurrence. The literature mostly reported cases of urethral leiomyoma arising from the proximal urethra. In our case, we report a distal urethral leiomyoma, which is an unusual location.
This young lady was a 32-year-old Filipino (Asian) lady who presented with mass per vagina, recurrent UTI, difficulty in micturition, discharge per vagina, the feeling of fullness in the vagina, difficulty and unpleasantness during sex for 2.5 years. She came with previous medical records & USG which disclosed many differential diagnoses of PID, cystocele, urethrocele, embryological remnant cyst, urethral diverticulitis and caruncle. She was treated for her complaints, nonetheless, her symptoms gradually became more disabling. After a thorough urogynecological investigation, which included an ultrasound, MRI with contrast and biopsy of the mass, the precise diagnosis of a distal urethral benign leiomyoma’ was made. She underwent a complete surgical excision under general anaesthesia, with excellent post-operative recovery, and was well relieved of all her complaints.