bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multivariate approach to the water quality environment of a tropical lake surrounded by agricultural land
Authors: Edwin Tivany , Komala Puti Sri , Mera Mas , Helard Denny , Bachtiar Vera Surtia 
Published: April 2023

Abstract

Lake Diatas is a tropical lake surrounded by agricultural land prone to pollution. A multivariate approach to lake water quality will be useful for lake management. The study's objectives are to describe fertiliser use by farmers around the lake, the lake's quality and trophic state spatially, and to use a multivariate approach to lake water quality. The results of a survey showed that most farmers use synthetic fertilisers because of low fertility soil, with self-estimated doses applied. The levels of total nitrogen (TN), total phosphorus (TP), and Secchi depth (SD) marginally exceeded the regulatory standard. However, the trophic status of the lake indicates an intermediate level of nutrients. Principal component analysis (PCA) showed the presence of two main factors with a variance of 85.46% – which showed the important drivers for lake water quality is mainly affected by agricultural activities around the lake. Cluster analysis showed three groups with the same water quality characteristics: the first group consists of locations with higher sulphate levels, the second with low SD, and the third with higher levels of TN and TP. Clearly, agricultural activities affect lake water quality and management regarding land use around the lake is important to prevent pollution.
“Coronacrise”
Authors: Oliveira Esmael Alves de , Paranhos Martins Catia , Aurélio da Silva Marcos 
Published: April 2023

Ao sermos interpelados/as pelo atual cenário político-pandêmico e diante de um quadro tão incerto quanto o que vivemos, somos desafiados/as a refletir não apenas sobre os “limites”, mas também sobre as “possibilidades” inauguradas em tempos de crise. Assim, num movimento de disputa crítica e analítica frente aos inúmeros eventos do presente, buscamos, a partir de uma perspectiva transdisciplinar e emdiálogo com autores e autoras que versam sobre as (bio)políticas contemporâneas, tecer breves considerações sobre os efeitos necropolíticos da crise da Covid-19 no Brasil. A partir de um levantamento bibliográfico e da análise de algumas notícias, concluímos que, se a pandemia é um problema de todos/as, a lógica necropolítica em curso no Brasil faz com que ela incida, principalmente, sobre sujeitos e coletivos atravessados por marcadores sociais de diferença, colocando-se como desafio para as ciências humanas e sociais que têm acionado toda uma expertise na área da saúde para refletir e contribuir diante desse contexto.
ALK and ERBB2 Protein Inhibition is Involved in the Prevention of Lung Cancer
Development by Vincamine
Authors: Verma Aarti , Yadav Poonam , Rajput Sonu , Verma Saloni , Arora Sahil , Kumar Raj , Bhatti Jasvinder Singh , Khurana Amit , Navik Umashanker 
Published: April 2023

Background:
According to the WHO report of 2022, 2.21 million new cases and 1.80 million deaths were
reported for lung cancer in the year 2020. Therefore, there is an urgent need to explore novel, safe, and effective therapeutic interventions for lung cancer.

Objective:
To find the potential targets of vincamine using a network pharmacology approach and docking studies and
to evaluate the anti-cancer effect of vincamine on A549 cell line.

Methods:
Hence, in the present study, we explored the anti-cancer potential of vincamine by using network pharmacology, molecular docking, and in vitro approaches. Network pharmacology demonstrated that the most common targets of vincamine are G-protein coupled receptors, cytosolic proteins, and enzymes. Among these targets, two targets,
ALK and ERBB2 protein, were common between vincamine and non-small cell lung cancer.

Results:
We discovered a link between these two targets and their companion proteins, as well as cancer-related pathways.
In addition, a docking investigation between the ligand for vincamine and two targeted genes revealed a strong affinity
toward these targeted proteins. Further, the in vitro study demonstrated that vincamine treatment for 72 h led to dosedependent (0-500 µM) cytotoxicity on the A549 lung cancer cell line with an IC50 value of 291.7 µΜ. The wound-healing
assay showed that vincamine treatment (150 and 300 µM) significantly inhibited cell migration and invasion. Interestingly,
acridine orange/ethidium bromide dual staining demonstrated that vincamine treatment induces apoptosis in A549 cells.
Additionally, the dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay showed an increased level of reactive oxygen
species (ROS) after the vincamine treatment, indicating ROS-mediated apoptosis in A549 cells.

Conclusion:
Altogether, based on our findings, we hypothesize that vincamine-induced apoptosis of lung cancer cells
via ALK and ERBB2 protein modulation may be an attractive futuristic strategy for managing lung cancer in combination with chemotherapeutic agents to obtain synergistic effects with reduced side effects.
Investigation of Anti-inflammatory, Antipyretic and Analgesic
Activities of Citrullus colocynthis in Albino Rats through in vivo
and Pharmacoinformatics Studies
Authors: Hassan Mubashir , Zahra Nureen , Shafi Amtul , Shahzadi Saba , Moustafa Ahmed , Kloczkowski Andrzej 
Published: April 2023

Introduction:
Hyperpyrexia, algesia and inflammation are pathological disorders
which are treated with synthetic as well as herbal medications.

Aims:
The basic aim of the present study is to evaluate the ethnopharmacological activities
of phytoconstituents that are present in C. colocynthis (fruit extract) by using in vivo and in
silico studies.

Methods:
Thirty-six albino rats were used in our studies with an average weight between
150-170 g. Anti-inflammatory activity was investigated using carrageenan (an extract from
a red seaweed) that induced edema in albino rat paws. However, in antipyretic and analgesic
activity studies, yeast and acetic acid were used to cause pyrexia or algesia, respectively. Different
doses of acetone fruit extract were used to treat inflammation, pyrexia and algesia.

Results:
Our results showed that the maximum percentage inhibition of acetonic fruit extract
in anti-inflammatory and analgesic activities was observed at 70% and 100%, respectively,
with 400 mg/kg doses, and in pyretic activity the maximum inhibitory percentage
was 86% with a 100 mg/kg dose. In in silico analysis, we have shown that bioactive compounds
(α-spinasterol, ascorbic acid and chlorogenic acid) found in fruit extract have outstanding
inhibition properties that involves proteins PTGS2, TLR2 and TRPV4. C. colocynthis
fruit extract shows results that are statistically significant (p < 0.005) and comparable
to a reference drug. Acetonic fruit extract of C. colocynthis can be used as a natural and
safe remedy with no side effects.

Conclusion:
Both in vivo and in silico studies on chlorogenic acid, ascorbic acid and α-spinasterol
have shown that these are inhibitory compounds that can be used for boosting the immune response.
Kriminālprocesa obligātums un lietderīgums kā kriminālās justīcijas sistēmas pamatprincips
Authors:   Latvijas Universitāte, Strada-Rozenberga Kristīne , Meikališa Ārija , Kūtris Gunārs , Leja Māris , Kulmanis Oskars , Gribonika Ērika 
Published: April 2023

Kri-minālprocesa obligātums, kurš kā kriminālprocesa pamatprincips nostiprināts Latvijas Kriminālprocesa kodeksa 6. pantā, nereti ikdienas retorikā minēts kā viens no nozīmīgākajiem šķēršļiem efektīva procesa norisei Latvijā. Iespējams, tieši tāpēc Eiropas Sociālā fonda projekta “Justīcija attīstībai” (Nr. 3.4.1.0/16/I/001) ietvaros 2022. gadā tika pasūtīts un Latvijas Universitātes Juridiskajā fakultātē veikts pētījums “Kriminālprocesa obligātuma principa ietekme uz kriminālpro-cesa efektivitāti”, kura pārskats arī ir šīs monogrāfijas pamatā.
ANTHROPOLOGICAL THEORY OF DIDACTICS AND DIDACTIC TRANSPOSITION: ANALYSING THE OBJECT-SUBJECT-INSTITUTIONS RELATIONS INTO OF THE THOUGHTS COLLECTIVES AND STYLES UNDER THE FLECKIAN REFLECTIVE
Authors: Da Silva Luciano Pontes , Da Fonseca Laerte Silva 
Published: April 2023

Este presente trabalho comenta uma análise sobre as Transposições Didáticas (TD) e Teoria Antropológica da Didática (ATD), de Yves Chevallard, na perspectiva da epistemologia de Fleck. Em primeiro lugar, é mostrado sobre Fleck e sua história, obras e conceitos dentro de sua epistemologia como um coletivo de pensamento e estilo de pensamento. Depois, discutiremos o que são a ATD e a DT, além de falar sobre Chevallard e seu trabalho. Na terceira parte, será feita a análise das duas teorias sob reflexão fleckiana, a qual é o principal objetivo deste artigo. Por fim, será discutida a pesquisa no campo empírico, aonde serão discutidas dados quantitativos sobre artigos publicados no BDTD - CAPES sobre a tônica dos círculos de pensamento, usando essas mesmas como referência de pesquisa no referido banco, e do estilo de pensamento. Nos resultados percebeu-se que o coletivo de pensamento mudou, dado que o estilo de pensamento também mudou. PALAVRAS-CHAVE: Coletivos de Pensamento; Estilos de Pensamento; Didática; Ensino; Epistemologia
Analysis of Factors Affecting The Success of Business Performance in Leading Products of Micro and Small Medium Enterprises in Central Java
Authors: Aziz Fathul Aminudin , Utami Hastin Tri 
Published: April 2023

Purpose: This study aims to determine the internal factors and external factors that influence the success of Micro and Small Medium Enterprises’s business performance of leading products in Central Java. Respondents in this study were 181 MSMEs delivered from various regencies in Central Java Province.
Methodology: Hypothesis testing conducted by performing multiple linear regression tests with SPSS 25 for windows.
Main Findings: The results of the study showed that internal factors: human resources, the use of accounting information and the use of information technology had a significant positive effect on the success of business performance and external factors which are government support and the business climate also had a significant positive effect on the success of business performance.
Implication: The future studies could be more specialized in the types of MSMEs such as: business food, batik or handicraft so that the research results can be compared. Further research can also add both internal or external variables such as owner knowledge, business age, business scale or competitiveness. Future studies can also use other variables as moderating or intervening variables.
Novelty/Originality of this Study: To date, there are no studies that examine internal factors (the ability of human resources, the use of accounting information and the use of information technology) and external factors (government support and business climate) affecting the success of business performance in leading products of micro and small medium enterprises in central java
The Impact of Community Social Changes on the Digitalization of the Implementation of Stock Waqf
Authors: Nimah Rodotun 
Published: April 2023

Abstract
The practice of cash waqf, especially stock waqf, in the last 5 years in Indonesia has increased in addition to other cash waqf. This is the impact of increasingly sophisticated digitalization developments that affect people's mindsets. Stock waqf is a new innovation because waqf through money is considered to have a more flexible nature to make new breakthroughs according to the needs of the times without reducing the essence of the waqf. Waqf shares are usually intended for productive social purposes or investments, the results of which are for the benefit of the people. The public or entrepreneurs are more interested in stock waqf because it can be channeled directly through nadzir waqaf and is easy to access. In general, the model for implementing stock waqf is derived from profits management of shares which are then given to waqf management institutions for then add to the benefits of waqf in the form of productive assets as well as physical assets that are useful for social.This research is a library research using a sociological approach. The type of research used is qualitative research using documentation data collection techniques and then analyzed by reducing data, presenting data and then drawing a conclusion. So that innovation in the form of cash waqf in Indonesia due to the positive impact of social changes in society is known comprehensively and has a strong legal basis.
Keywords: Impact of Change, Social Society, Digitization, Stock Waqf.
Robot-assisted laparoscopic prostatectomy: a costs and break-even point analysis for decision-making in a university hospital and a regional healthcare system in Northern Italy
Authors: Fabbro Elisa , Crivellaro Simone , Dalle Fratte Chiara F. , Vetrugno Luigi , Adani Gianluigi , Saule Barbara , Drigo Daniela , Zumerle Giulia , Favaretti Carlo , Guarrera Giovanni M. 
Published: April 2023

BACKGROUND: Robotic Assisted Radical Prostatectomy (RALP) is one of the most expensive urological innovations. Prices of the “Da Vinci System” range from € 761.105 to € 1.902.762 for each unit, without taking into account the cost of maintenance and the use of additional devices. We evaluated outcomes, and costs retrospectively, comparing RALP to open retro-pubic radical prostatectomy (RRP) performed in our hospital between December 2009 and December 2010.
METHODS: We compared 53 RALP, and 50 RRP in terms of costs, and clinical outcomes. We also implemented a Break Even Analysis in order to evaluate if the public reimbursement covered the total cost of RALP.
RESULTS: According to our analysis, RALP showed lower hospitalization (p < 0,0001), higher early continence rate (p < 0,0001), better potency rate in nerve sparing procedures (p < 0,0142), and required no transfusions. Excluding the cost of purchasing and maintenance, single case costs were € 6.046,08 for RALP and € 4.834,11 for RRP, respectively. Considering the affordability of the technology, the point where the total revenue is sufficient to cover the total costs is an average of 60 cases performed per year, only in presence of additional reimbursement.
CONCLUSIONS: Although our clinical analysis shows better results in favour of RALP, the economical analysis shows that RALP's costs are consistently higher than RRP. Considering also the purchasing costs, we demonstrate that the health gain of the technology does not necessarily offset the higher costs, even in a large, university hospital (1.000 beds).
New indicators of health among adolescent drug users and evaluation of drug policies comparing countries
Authors: Ventura Elena , +Wagner Harrison , Rossi Carla 
Published: April 2023

By correlating essential features of the national drug legislations and policies of some European countries and various indicators of consumption and health of consumers, interesting patterns emerge.
We conclude that it is the correct balance between a drug policy aimed at prevention, rehabilitation, and a less restrictive legislation, that, on the basis of what we have analyzed and measured, has a positive effect on drug consumption and that indicators are efficient and should be applied regularly to compare quantitatively country policies to identify best practices.
An outbreak of Streptococcus pneumoniae in an Italian nursing home
Authors: Papalia Riccardo , Galotto Chiara , Giacomazzi Claudio , Verardo Marina , Montanera Piergiorgio , Bongiorno Salvatore , Novati Roberto 
Published: April 2023

Streptococcus pneumoniae is the main cause of community-acquired pneumonia worldwide; pneumonia occurs sporadically in most cases, but rare outbreaks have been reported. We describe an outbreak occurred in a 21-guests nursing home for elders in Aosta (Italy); outbreak occurred in april 2014 over a 2 weeks period, resulting in 12 out 20 guests affected (all with high fever and respiratory symptoms), two deaths (at home), nine patients referred to Hospital Emergency Room, and eight admissions. Urinary streptococcus antigen was positive in seven out of eight patient tested. None of the nursing home guests were vaccinated against Streptococcus pneumoniae
The Hospital Medical Direction and Public Health Service gave support and adopted strategies to contain the outbreak spread.
We underline the need for pneumococcal vaccination in nursing homes/ Long-term care facilities; accurate check of hygiene behaviours in those setting is also mandatory.
Ecological Study to Set Alternative Strategies for Reducing Child Mortality
Authors: Abdel-Razik Madiha Said Mohamed , El Rabbat Maha , Elden Nesreen Mohamed Kamal , Ali Hanazghloul Yousof 
Published: April 2023

Background: Infant and child mortality are indicators of population wellbeing. Although, Child mortality rates are declining in Egypt, national averages mask regional disparities. For that, identification and quantification of factors contributing to mortality, at the local level, through ecological correlation studies could provide a guide to more focused public health interventions for reducing mortality. The study aims to improve child health and decrease child mortality rate through recognizing ecological/environmental factors predicting child mortality among municipalities in Giza governorate.
Methodology: Ecological, cross sectional study, adopting the municipalities (n=215) as unit of analysis, was conducted to examine associations between child mortality and some human development indicators.
Results: High negative significant correlation between U5MR and access to water (r=-0.966) was found. Access to sanitation and access to electricity are negatively correlated with U5MR with r=-0.955 and - 0.905 respectively. The results with IMR were similar to that with U5MR. An increase in one percentage access of household to safe water predict 1.05and 0.78 fewer U5MR and IMR (R2=0.97 and 0.98; P≤0.001) respectively. U5MR and IMR decrease, significantly, by 0.82 and 0.61deaths, respectively, with increase access to sanitation by 1%.
Conclusion: Access to safe water and sanitation are strong predictors of U5MR and IMR. Increase coverage of households by safe water has the largest impact in reduction of children mortality rate. For that, the study recommends advocacy to ensure coverage of household with safe water and sanitation system.
Gender differences in reaching top roles in banking: a cross-sectional study performed by bankers work in province of Pisa
Authors: Colamesta Vittoria , Marchini Laura , Bertazzoni Giuliano , Polimeni Antonella , La Torre Giuseppe 
Published: April 2023

The financial industry is a pivot of the economy and plays an important social role.
Goal of this study was to analyze factors associated with the framing level in banking in the province of Pisa.
We collected data about age, gender, framing level, workplace and type of bank for bankers in Pisa through trade unionists.
We collected data on 2018 workers and we found significant associations between framing level and aged over 40 years (OR = 4.5; 95% CI: 2.9-6.9), workplace in Pisa (OR = 0.30; 95% CI: 0.20-0.44) and male gender (OR = 2.89; 95% CI: 1.98-4.21).
The first two factors are explainable with organizational characteristics. In fact for becoming manager you already have to work a number of year and in cities rather than in the surrounding municipalities, consistent with the size of bank.
However, the third factor, already known in the literature in other work areas, requires further studies for explaining causes and helping to implement actions to reduce the gender gap.
Choosing the right strategy to model longitudinal count data in Epidemiology: An application with CD4 cell counts
Authors: De Brito Trindade Daniele , Ospina Raydonal , Amorim Leila D. 
Published: April 2023

Background: Statistical models for analysis of correlated count data are important for answering epidemiological questions that involve taking individual count measurements repeatedly over time through the use of longitudinal studies. Conventional regression models for this type of data are inadequate, leading to improper conclusions and inference. An important application of longitudinal studies in Public Health is the evaluation and monitoring of patients with infectious diseases, such as HIV/AIDS, to determine their health status, to verify the treatment effects, and to make prognosis concerning the evolution of the disease, including interdependencies of clinical manifestations. The purpose of this article is to characterize different statistical strategies for analysis of longitudinal count data, emphasizing how to choose the most suitable model for the data and how to interpret the results.
Methods:We illustrate their applicability by evaluating the effect of associated factors on lymphocyte CD4+T cell count in HIV seropositive patients in Salvador/Bahia - Brazil. We describe Poisson and Negative Binomial models using multilevel (ML) approach and generalized estimations equations (GEE) for analysis of longitudinal count data.
Results: It is worth noting that the interpretation of the results from ML and GEE differs and they should not be compared directly.
Conclusion: We believe that the statistical methodology for analysis of longitudinal studies with correlated count data can be useful to address several important questions in public health, particularly by helping to monitor patients and checking the effectiveness of treatments.
Distributed Lag Nonlinear Modelling Approach to Identify Relationship between Climatic Factors and Dengue Incidence in Colombo District, Sri Lanka
Authors: Talagala Thiyanga 
Published: April 2023

Dengue fever and its more severe deadly complication dengue hemorrhagic fever is an infectious mosquito borne disease. The rise in dengue fever has made a heavy economic burden to the country. Climate variability is considered as the major determinant of dengue transmission. Sri Lanka has a favorable climatic condition for development and transmission of dengue. Hence the aim of this study is to estimate the effect of diverse climatic variables on the transmission of dengue while taking the lag effect and nonlinear effect into account. Weekly data on dengue cases were obtained from January, 2009 to September, 2014. Temperature, precipitation, visibility, humidity, and wind speed were also recorded as weekly averages. Poisson regression combined with distributed lag nonlinear model was used to quantify the impact of climatic factors. Results of DLNM revealed; Mean Temperature 250C – 270C at lag 1 – 8 weeks, Precipitation higher than 70mm at lag 1- 5 weeks and 20- 50mm at lag 10 – 20 weeks, humidity ranged from 65% to 80% at lag 10 – 18 weeks, visibility greater than 14 km have a positive impact on the occurrence of dengue incidence while, mean temperature higher than 280C at lag 6 – 25 weeks, maximum temperature at lag 4 – 6 weeks, precipitation higher than 65mm at lag 15 – 20 weeks, humidity less than 70% at lag 4 – 9 weeks, visibility less than 14km, high wind speed have a negative impact on the occurrence of dengue incidence. These findings can aid the targeting of vector control interventions and the planning for dengue vaccine implementation.