bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN E-MODUL BERBASIS HEYZINE DI GUGUS MENES
Authors: Pratiwi Wiwik , Hidayat Sholeh , Suherman Suherman 
Published: July 2023

ABSTRAKKreativitas dan inovasi sangat dinanti oleh pemerintah untuk proses pembelajaran yang menyenangkan. Menghasilkan produk elektronik berupa konten materi ialah harapan yang diinginkan oleh peneliti. Materi ini dijabarkan ke bentuk visual dengan memanfaatkan heyzine. Hadirnya beberapa tools pendukung guna membuat bahan ajar salah satunya adalah heyzine yaitu tools dari canva. Heyzine adalah flipbooks yang penggunaannya berbentuk flip, sehingga pengguna dapat menggunakannya seperti membaca buku cetak biasa. Untuk mendapatkan tujuan ini peneliti menggunakan penelitian Reasearch and Development (R&D) dengan model 4D. Pendefinisian, desain, pengembangan, dan penyebaran adalah empat fase dari model ini. Berdasarkan hasil tahapan yang dilakukan dengan model 4D bisa dikonklusikan, bahan ajar dikembangkan menggunakan heyzine amat mudah dipahami dan menarik bagi guru-guru SD di Gugus Menes.Kata Kunci: heyzine, model 4D, modul proyek, flipbook, kurikulum ABSTRACTCreativity and innovation are highly anticipated by governments for the fun learning process. Research is carried out with the producing a product of material content. The material was developed in a visual format using heyzine. In addition to several contributing applications, one is heyzine, which is canva tools. Heyzine is the flipbooks that use them in the shape of a flip, so users can use them as if they were reading a normal print book. To achieve that goal the researchers used research and development (r&d) research with model 4D. Define, design, development, and disseminate are four phases of this model. Based on the results of the 4D model, the teaching material developed with heyzine was perfectly understandable and interesting to elementary school teachers on the Menes.keywords: heyzine, 4D models, project module, flipbook, curicullum
cTULIP: application of a human-based RNA-seq primary tumor classification tool for cross-species primary tumor classification in canine
Authors: Long Jiaxin , Ganakammal Satishkumar Ranganathan , Jones Sara E. , Kothandaraman Harish , Dhawan Deepika , Ogas Joe , Knapp Deborah W. , Beyers Matthew , Lanman Nadia A. 
Published: July 2023

IntroductionThe domestic dog, Canis familiaris, is quickly gaining traction as an advantageous model for use in the study of cancer, one of the leading causes of death worldwide. Naturally occurring canine cancers share clinical, histological, and molecular characteristics with the corresponding human diseases.MethodsIn this study, we take a deep-learning approach to test how similar the gene expression profile of canine glioma and bladder cancer (BLCA) tumors are to the corresponding human tumors. We likewise develop a tool for identifying misclassified or outlier samples in large canine oncological datasets, analogous to that which was developed for human datasets.ResultsWe test a number of machine learning algorithms and found that a convolutional neural network outperformed logistic regression and random forest approaches. We use a recently developed RNA-seq-based convolutional neural network, TULIP, to test the robustness of a human-data-trained primary tumor classification tool on cross-species primary tumor prediction. Our study ultimately highlights the molecular similarities between canine and human BLCA and glioma tumors, showing that protein-coding one-to-one homologs shared between humans and canines, are sufficient to distinguish between BLCA and gliomas.DiscussionThe results of this study indicate that using protein-coding one-to-one homologs as the features in the input layer of TULIP performs good primary tumor prediction in both humans and canines. Furthermore, our analysis shows that our selected features also contain the majority of features with known clinical relevance in BLCA and gliomas. Our success in using a human-data-trained model for cross-species primary tumor prediction also sheds light on the conservation of oncological pathways in humans and canines, further underscoring the importance of the canine model system in the study of human disease.
Burnout, psychological wellbeing, and musculoskeletal complaints in UK GPs: an observational study
Authors: Biddle Gregory JH , Thomas Nicholas , Edwardson Charlotte L , Clemes Stacy A , Daley Amanda J 
Published: July 2023

BackgroundHealthcare systems are under unprecedented pressure. GPs are crucial to the health of the population, yet their own health and wellbeing is often overlooked.AimTo investigate feelings of burnout, psychological wellbeing, and musculoskeletal complaints in GPs across the UK and to examine whether these health outcomes vary according to the time GPs spent sitting, their participation in physical activity each day, and the time spent working per day or week.Design & settingObservational study involving GPs located across the UK.MethodAn online survey was emailed to working members of the Royal College of General Practitioners and shared on social media between October and December 2020. The survey included questions on burnout, psychological wellbeing, musculoskeletal complaints, sitting time, physical activity, and time spent working. Mean differences were examined for burnout, psychological wellbeing, and musculoskeletal complaints.ResultsData from 406 GPs showed a high level of burnout (35.5%) and musculoskeletal complaints (neck, shoulder and back: 81.8%; arms: 28.3%; and legs: 49.8%). Psychological wellbeing was low in 22.9% of GPs. Burnout was lower in GPs who met current physical activity guidelines, while psychological wellbeing was higher in those with >2 breaks in sitting per hour. Musculoskeletal complaints were higher in those spending >50% of sitting time in prolonged bouts (≥30 minutes).ConclusionA high proportion of GPs reported experiencing burnout and musculoskeletal complaints, but these health concerns were less evident in GPs who spent less time in prolonged sitting, took more breaks in sitting, and who were more physically active.
Review of modern materials for the treatment of pulpal hyperemia
Authors: Adamchik A. A. , Kirsh K. D. , Ivashchenko V. A. , Zaporozhskaya-Abramova E. S. 
Published: July 2023

Background. The treatment of pulp inflammation takes an important place among modern dentistry problems. Depulpated teeth in some cases become chronic source of infection. They could also cause an odontogenic infection of the maxillofacial region. In this regard, it is important to use conservative methods of treatment to eliminate the inflammatory process in the dental pulp and preserve the vitality of the tooth.Aim. The aim of this study is to collect and systematize the information about modern aspects of the conservative treatment of pulp hyperemia that is presented in scientific articles and to study the effects and impacts of bioactive materials on pulp tissues.Materials and methods. A search was made for literature sources in the database: PubMed, dissercat.com, elibrary.ru, cyberleninka.ru using the keywords «caries», «pulp hyperemia», «pulpitis», «bioactive materials» with a choice of article types «Clinical Trial», «Meta-Analysis», «Review», «Systematic Review».Results. After analyzing the literature review, an idea was obtained about the pathogenesis of the pulp at various stages of inflammation, criteria for its clinical assessment of the morphological state, pathophysiological and cytological processes of the pulp when exposed to bioactive materials. A modern classification and review of bioactive materials used in the treatment of pulp hyperemia is presented.Conclusions. Studying the literature on the morphology and pathophysiology of the pulp, on its reserve possibilities of the regeneration plan, it was found that the inflammation in the dental pulp is reversible. This requires modern therapeutic materials that cause the reverse development of inflammation in the dental pulp. A conservative method of treating pulp hyperemia involves using materials that restore the structural and functional properties of the pulp, so preserve its vitality. This review article provides an overview of the materials used in the conservative treatment of pulp hyperemia according to Russian and foreign literature.
Assessment of the state of free radical oxidation in patients with lichen plus by the chemiluminescence method
Authors: Vildanov M. N. , Gerasimova L. P. , Chemikosova T. S. , Golub A. A. 
Published: July 2023

One of the non-invasive methods for assessing oxidative stress is the study of the oral fluid of patients by chemiluminescence. Based on the data obtained, it is possible to quantify the degree of oxidative stress and adjust the prescribed therapy.Objectives. To assess the state of free radical oxidation of the oral fluid by chemiluminescence (CL) in patients with various verified forms of oral lichen planus (OLP), compare the data obtained with those in the control group.Materials and methods. 287 patients with various forms of OLP of the oral mucosa and 32 patients of the control group, comparable in sex and age, were studied. The assessment of oxidative stress was carried out using the device HL-003, examining the oral fluid.Results. The parameters S, Imax of individual forms of OLP had statistically significant differences compared with those of the control group of patients. Thus, the erosive-ulcerative form of OLP by the S parameter exceeded the conditional norm by 2.45 times, by the Imax parameter it exceeded by 2.37 times; exudative-hyperemic form exceeded the norm in parameter S, exceeded the conditional norm by 2.12 times, in parameter Imax exceeded 1.71 times; atypical form of OLP had a statistically significant excess in Imax by 1.49 times; the bullous form of OLP had a statistically significant excess in the S parameter by 2.18 times. Other forms of OLP (typical, hyperkeratotic) did not have statistically sign100ificant differences in the parameters S, Imax.Conclusions. The obtained data substantiate the inclusion of antioxidant therapy in the ongoing OLP therapy; indicators of CL in the oral fluid can be one of the biomarkers in the diagnosis and monitoring of therapy in OLP, especially in the long term, mainly in erosive-ulcerative, exudative-hyperemic, atypical and bullous forms of OLP.
Dystrophic changes in the teeth and their surrounding tissues in destructive forms of apical periodontitis
Authors: Glinkin V. V. , Dzholov M. S. , Shatiev K. Kh. 
Published: July 2023

Aim. With the help of pathomorphological studies, to study dystrophic changes that occur in teeth with destructive forms of periodontitis in the acute stage and in the tissues surrounding them.Materials and methods. For morphological study, biopsies of 48 teeth and periapical foci of infection of destructive forms of apical periodontitis in the acute stage were used. The material processed according to generally accepted methods was studied using an Olympus BX-40 light microscope.Results. Dystrophic changes were observed in 9 out of 48 studied teeth, which amounted to 18.75 %. Various manifestations of dystrophy testified to pathomorphological changes in tissues during the chronic course of the disease.Conclusions. Exacerbation of the inflammatory process in destructive periodontitis is accompanied by an autoimmune response of the body. Calcifications indicate changes in tissues. Dystrophy leads to total necrosis of pulp and periodontal tissues. Tissue granulomas with signs of dystrophy, chronic inflammatory process. Accumulation in the tissues of dental granulomas during the period of exacerbation of GAG is uneven, mostly of low and moderate intensity with a predominance of non-sulfated compounds. The body on its own is not able to cope with a long-standing inflammatory process.
O peso das mochilas de escolares de 10 a 15 anos de uma escola pública no Paraná
Authors: Glass Jorge Alan , Anguera Maria das Graças 
Published: July 2023

A utilização regular de mochilas, frequentemente pesadas, por conta dos materiais necessários para o dia escolar apresenta uma variedade de riscos, principalmente durante o período de crescimento e especialmente na adolescência. Alguns estudos sobre a saúde destacam que as alterações posturais e as dores nas costas de escolares de 10 a 15 anos, são causadas pelo excesso de peso em suas mochilas. Nesse sentido, o objetivo do estudo foi averiguar se o peso das mochilas utilizadas por escolares entre 10 e 15 anos de uma Escola Pública do Paraná está adequado, aceitável ou inadequado de acordo com sua massa corporal, sugerido pela comunidade científica e estabelecido na Lei 17.482/2013. A verificação da adequação do peso da mochila em relação à massa corporal foi feita de acordo com dois parâmetros: um utilizando as classificações sugeridas pela comunidade científica: adequado (≤10% do peso corporal do sujeito); aceitável (≤15% do peso corporal do sujeito); inadequado (˃15% do peso corporal do sujeito) e o outro parâmetro utilizando as classificações sugeridas pela Lei 17.482/2013: adequado (≤10% do peso corporal do indivíduo) e inadequado (˃10% do peso corporal do indivíduo). Os resultados desse estudo demonstraram que quando feitas as médias agrupadas pela faixa etária, nenhum dos grupos esteve inadequado conforme os parâmetros da literatura que é de até 15% de peso transportado da massa corporal, porém, conforme a Lei 17.482/2013, quatro dos seis grupos etários estiveram inadequados, sendo eles de 10, 11, 12 e 14 anos. Finalmente, existe uma diferença bem significativa, quando comparamos as duas referências de análises, pois, avaliando o resultado da proposta dos autores, a maioria dos pesos das mochilas investigadas se encontra nos padrões adequado e aceitável, que juntos representam quase 90% da amostra, e quando analisado os resultados a partir da Lei 17.482, prevalece o padrão inadequado.
Lipid profile in patients with leiomyoma-A case-control study
Authors: Prasad H.L. Kishan , Dasan Nimmy Maria , Kishan Ashwini , Kumari N. Suchetha 
Published: July 2023

Introduction and Aim: The most frequent gynaecological neoplasm in women of reproductive age is leiomyoma (Fibroid). They are hormone-dependent tumours, and estrogen will promote their development. It has been found that estrogen levels and cholesterol levels are inversely associated. Few studies have shown no relation between lipid profile and leiomyoma, but few studies suggested a positive correlation. The lipid profile of patients with uterine fibroids (the case group) and women without fibroids (the control group) is compared in the current study.

Materials and Methods: The case-control study included fifty subjects between 20 to 40 years. Twenty-five serum samples collected from women without evidence of leiomyoma were considered the control group. Twenty-five cases were admitted with various symptoms, diagnosed and confirmed as leiomyoma on histopathology.

Results: There was a substantial difference in Total Cholesterol (TC) and Low-Density Lipoprotein cholesterol (LDL-C) levels between patients with leiomyoma and healthy people. With a p-value of 0.04, the TC, LDL-C level in leiomyoma patients was substantially lower than that of healthy individuals in the general population. The levels of triglycerides, High-Density Lipoprotein cholesterol (HDL-C), and Very Low-Density Lipoprotein cholesterol (VLDL-C) were comparable across the case and control groups, though.

Conclusion: According to the study's findings, patients with leiomyoma have lower serum TC and LDL-C levels than healthy controls. This could be linked to patients with leiomyomas having higher estrogen levels. As a result, lipid profile variables like TC and LDL-C may be accurate indicators of leiomyoma. These findings point to the possibility of blood plasma lipid profiling for the non-invasive diagnosis of fibroids.
Clinicopathological spectrum of cervicofacial actinomycosis
Authors: G. V. Chaithra , K. B. Vatsala , Gupta Soumya , Mohan Murali , Adiga Deepa , Sarah Philipose Cheryl , Rao Ranjitha 
Published: July 2023

Introduction and Aim: Cervicofacial actinomycosis is a rare chronic granulomatous disease caused by Actinomyces and is the commonest subtype of actinomycosis. Due to the similarities in clinical presentation, cervicofacial actinomycosis is almost always suspected as malignancy or tuberculosis. Histopathological evaluation is crucial in diagnosis and management of these cases. The aim of the study was to evaluate the clinicopathological features of cervicofacial actinomycosis in the biopsy specimens.

Methodology: This is a retrospective cross sectional observational study of 17 years duration. All cases of cervicofacial actinomycosis diagnosed on biopsy specimens were analyzed. Clinical presentations and histomorphological features were evaluated on hematoxylin and eosin-stained slides with confirmation of organism on special stains.

Results: Out of 36 diagnosed cases of actinomycosis during the study period, we evaluated 16 cases (44.4%) of cervicofacial actinomycosis. Mean age of presentation was 38 years. Male to female ratio was 1:0.9. The anatomical sites of eight (50%) were in the oral cavity, six (37.5%) on the face and two (12.5%) in the neck. Two cases (12.5%) had sinuses discharging sulphur granules. Six cases (37.5%) were clinically suspected as malignant and among them two cases (12.5%) also had differential diagnosis of tuberculosis. All cases on histomorphology showed sulphur granules consisting of basophilic filamentous bacterial colonies with Splendore Hoeppli phenomenon and mixed inflammation. On special stains, the bacterial colonies were Gram, PAS and GMS stain positive, and acid fast negative.

Conclusion: Cervicofacial actinomycosis are uncommon. Their presentation can mimic carcinoma or tuberculosis. Consistent histomorphological features can direct towards identification of organisms by special stains for confirmation of diagnosis.
Efficacy of microcurrent therapy versus laser therapy for diabetic foot ulcer on size of the wound
Authors: M. Kamalakannan , S. Chitra , V. Shruthi Kamal 
Published: July 2023

Introduction and Aim: Diabetes mellitus (DM) will increasingly contribute to years of life and disability worldwide. Approximately 25% of individuals with diabetes will develop diabetic foot ulcers. This study aimed to assess the effectiveness of microcurrent therapy compared to low-level laser therapy in terms of wound healing and quality of life among patients with diabetic foot ulcers.

Materials and Methods: This study followed a prospective randomized open blinded endpoint assessment (PROBE) design with two parallel groups allocated in a 1:1 ratio. Participants meeting the selection criteria and having diabetic foot ulcers were included. Baseline measurements were taken before randomly assigning participants to the treatment groups. Pre-test and post-test data were collected to evaluate the wound size.

Results: The t-test analyses demonstrated significant improvement in both treatment groups (LLLT: t = 41.818, p < 0.001; Micro-Current Group: t = 32.787, p < 0.001). To compare the groups, One-Way Analysis of Variance (ANOVA) was conducted, indicating a significant difference in ulcer size between the LLLT group (mean value: 62.600, SD=3.035) and the microcurrent therapy group (mean value: 51.933, SD= 6.938).

Conclusion: This study concludes that microcurrent therapy is more effective than low-level laser therapy for managing diabetic foot ulcers. The findings suggest that a 3-week intensive physiotherapy therapeutic approach, combined with conventional medical treatment, yields the best results in terms of wound healing.
Antibacterial action of AgNPs produced from different isolates of Gram positive and Gram-negative bacteria on biofilm of Klebsiella pneumoniae isolated from RTI
Authors: Ali Ahmed Suaad , Mahmood Hasan Hussam , Ghassan Sweedan Enass 
Published: July 2023

Introduction and Aim: Klebsiella pneumoniae is a Gram-negative bacterium responsible for a wide range of infections, including respiratory tract infections (RTIs). This research was aimed to study the antibacterial and anti-biofilm effect of AgNPs produced by Gram positive and negative bacteria on RTIs associated with K. pneumoniae.

Materials and Methods: The biofilm formation of K. pneumoniae was determined by tube method qualitatively from select bacterial species characterized by UV-Visible spectroscopy. The antibacterial susceptibility of the bacteria AgNPs was tested for their antibacterial and antibiofilm activity on a clinical isolate of K. pneumoniae.

Results: K. pneumoniae isolated from RTIs were strong biofilm producers. The antibacterial activity of AgNPs synthesized from bacterial spp in this study had good antibacterial activity against K. pneumoniae. P. aeruginosa and P. mirabilis AgNPs had the strongest anti-biofilm effect, with 84% and 83%, respectively, while A. baumanii's AgNPs had the lowest (79%). AgNPs of P. aeruginosa and P. luteola showed the highest (80%) anti-biofilm action against the development of pre- and post-mature biofilms formed by K. pneumoniae, while AgNPs from S. mitis exhibited the lowest levels (69%).

Conclusion: AgNPs generated by Gram positive and Gram-negative bacteria, when exposed to K. pneumoniae isolated from RTIs had a good antibacterial impact and inhibited the formation of biofilm by K. pneumonia and hence could be used as an antibacterial agent against K. pneumoniae infecting the respiratory tract.
Frequency of intestinal parasites among school children around Al Hawija, Kirkuk city
Authors: Ali Ahmed Neama , Huseen Jasim Abdullah 
Published: July 2023

Introduction and Aim: Intestinal parasite infections among children are a worldwide problem, particularly in developing countries. Intestinal parasitic infections can lead to several health issues including growth and physical development in children. This investigation aimed to determine the prevalence of intestinal parasites in school children residing in Al Hawija, Kirkuk.

Materials and Methods: This study, undertaken between May 2021 and October 2022, involved 247 children aged between 2 and 13 years residing at Al Hawija, Kirkuk City. Stools samples collected from these children were studied for intestinal parasitic infections.

Results: Of the 247 children 194 (78.6%) were seen to harbor intestinal parasites. Among these, the prevalence of protozoal and helminthic infection was observed to be 152 (61.5%) and 42 (17%) respectively. Among the protozoans, the highest prevalence was seen for Entamoeba histolytica (61.8%), followed by Giardia lamblia (30.9%) and Entamoeba coli (7.2%). Similarly, among helminthes, the highest infection was by Ascaris lumbricoidis (45.2%), followed by Enterobius vermicularis (21.4%), Trichuris trichura (11.9%), Hymenolepis nana (11.9%) and Taenia spp. (9.5%). The prevalence for these parasitic infections was observed to be highest in children aged 2-5 years.

Conclusion: Children aged between 2- 5 years are prone to parasitic infections in comparison to children between 10-13 years.