bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance imaging‐based risk factors of hepatocellular carcinoma after direct‐acting antiviral therapy: A multicenter observational study
Authors: Ichikawa Shintaro , Motosugi Utaroh , Sawai Yoshiyuki , Ishida Hisashi , Imai Yasuharu , Kozaka Kazuto , Tsurusaki Masakatsu , Sofue Keitaro , Murakami Takamichi , Kawai Nobuyuki , Matsuo Masayuki , Fukukura Yoshihiko , Mawatari Seiichi , Shimizu Tatsuya , Morisaka Hiroyuki , Inoue Taisuke , Goshima Satoshi 
Published: September 2023

AbstractAimTo determine risk factors associated with hepatocellular carcinoma (HCC) development following direct‐acting antiviral (DAA) therapy.MethodsWe enrolled patients with chronic hepatitis C who underwent direct‐acting antiviral therapy and achieved sustained virologic response at 12 weeks between 2012 and 2018. Subsequently, patients were followed up. The primary endpoint was the development of HCC or the date of the last follow up when the absence of HCC was confirmed. Uni‐ and multivariate Cox proportional hazards models were used to identify factors contributing to HCC development, including gadoxetic acid‐enhanced magnetic resonance imaging findings. The cumulative incidence rates of HCC development were calculated using the Kaplan–Meier method, and differences between groups were assessed using the log‐rank test.ResultsThe final study cohort comprised 482 patients (median age 70.5 years; 242 men). The median follow‐up period was 36.8 months. Among 482 patients, 96 developed HCC (19.9%). The 1‐, 3‐, and 5‐year cumulative rates of HCC development were 4.9%, 18.6%, and 30.5%, respectively. Multivariate analysis revealed that age, male sex, history of HCC, and hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were independent risk factors significantly associated with HCC development (p < 0.001–0.04). The highest risk group included patients with both a history of HCC and the presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement (the 1‐ and 3‐year cumulative HCC development rates were 14.2% and 62.2%, respectively).ConclusionHistory of HCC and presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were strong risk factors for HCC development following direct‐acting antiviral therapy.
Improving the green mechanical strength and thermal shock resistance of colloidal silica‐bonded castables using La2O3
Authors: Ding Yuhang , Liu Huiyong , Xue Haitao , Cong Peiyuan , Zhao Yinheng , Xiang Bing , Xia Changyong 
Published: September 2023

AbstractImproving the green mechanical strength of colloidal silica‐bonded corundum castables is essential to their widespread utility. The effects of varying contents (0–2 wt%) of La2O3 on the green mechanical strength of colloidal silica‐bonded corundum castables were investigated. The findings demonstrate that La2O3 has a positive impact on the green mechanical strength of colloidal silica‐bonded castables. The colloidal silica‐bonded corundum castable containing 2 wt% La2O3 exhibits higher green mechanical strength than the cement‐bonded corundum castable. Additionally, the castable shows excellent construction performance. The basic properties of La2O3 and La(OH)3 facilitate the absorption of H+ from the surface of colloidal silica to form more siloxane bonds and speed up gelation. Fourier transform infrared spectroscopy and X‐ray fluorescence spectroscopy analyses indicate that La3+ ions participate in the condensation of –Si–OH and bond the broken Si–O bonds to create Si–O–La chemical bonds. La3+ ions bridge the colloidal silica particles, leading to stable three‐dimensional network structures that result in an increased green mechanical strength of the castables. The water consumption during the hydration reaction expedites gelation, further contributing to the enhancement of the green mechanical strength of the corundum castables. Given its wide sources and stable performance, La2O3 can be considered an efficient setting agent with the potential for extensive industrial application.
Synergistic modulation of ferroelectric polarization and relaxor behavior of Sr2NaNb5O15‐based tungsten bronze ceramic
Authors: Si Peixiaokan , Zheng Peng , Zhang Xinzhong , Luo Chong , Zheng Xiangting , Fan Qiaolan , Bai Wangfeng , Zhang Jingji , Zheng Liang , Zhang Yang 
Published: September 2023

AbstractDeveloping dielectric ceramics with high energy storage performance (ESP) is essential for miniaturizing and integrating high‐power pulse capacitors. Sr2NaNb5O15‐based tungsten bronze ferroelectric ceramics have been highly investigated for dielectric energy storage applications recently. However, the difficulty in concurrently obtaining large polarization and strong relaxor characteristics greatly hinders the ESP improvement. In this work, Bi3+ and Ti4+ ions were introduced into the Sr2NaNb5O15 ceramic, aiming to modulate the ferroelectric polarization and relaxor behavior synergistically. An excellent recoverable energy density (Wrec ∼ 4.08 J/cm3) and a high efficiency (η ∼ 84.59%) were concurrently attained in the Sr1.85Bi0.15NaNb4.85Ti0.15O15 composition due to the boosted polarization and enhanced relaxor nature. Moreover, this ceramic also exhibited a high current density (863.06 A/cm2) and a large power density (94.94 MW/cm3). All these characteristics demonstrate that the Bi3+ and Ti4+ ions co‐doped Sr2NaNb5O15 ceramics possess great potential for dielectric capacitor applications.
Particle grading effect on properties of reactive MgO‐bonded castables
Authors: Zhang Hongrui , Zhao Zongqiang , Xiao Jintao , Jia Quanli , Ma Chengliang , Chen Liugang 
Published: September 2023

AbstractRefractory matrix is a key factor in determining the properties and performance and thus the lifetime of refractory materials. The particle gradation affected both the matrix composition and microstructure. In this study, six particle gradations of high‐alumina castables were prepared based on Andreasen's model (q = 0.22, 0.24, 0.26, 0.28, 0.30, and 0.32). The influence of particle gradation on properties of high‐alumina castables bonded with 4.0 wt% reactive MgO (RM) was investigated with respect to the difference in matrix composition and microstructure. The results show that castables with q values of 0.24 and 0.26 exhibited better physical and mechanical properties after curing and drying. The castables with a q value of 0.22 showed the best volume stability after firing at 1600°C, whereas, castables with a q value of 0.24 exhibited the highest mechanical strength, and residual CMOR ratio after thermal shock testing. Based on the property analyses of castables, the optimal q value of RM‐bonded castables would be around 0.24.
Inadéquation des qualifications parmi les travailleurs recrutés depuis peu: effets à court et moyen terme sur les salaires
Authors: ARAÚJO Isabel , CARNEIRO Anabela 
Published: September 2023

RésuméLes autrices analysent les effets salariaux à court et moyen terme de la surqualification et la sous‐qualification, à partir de données appariées employeur‐salarié relatives à la période 1998‐2012 et d'un nouvel outil de mesure de l'inadéquation, reposant sur les flux de nouvelles recrues. Elles constatent que ces effets diminuent sensiblement après prise en compte de l'hétérogénéité non observée des travailleurs et des entreprises. Les caractéristiques individuelles non observées contribuent largement à l'écart salarial aux dépens des travailleurs surqualifiés et au profit des salariés sous‐qualifiés. Les politiques salariales des entreprises l'alimentent aussi. Enfin, c'est sur la rémunération du début de carrière que l'inadéquation influe le plus.
Cien años de reglamentación dinámica del salario mínimo en Australia, los Estados Unidos y el Reino Unido
Authors: HAMILTON Reg , NICHOL Matt 
Published: September 2023

ResumenEl salario mínimo ha sido una cuestión controvertida desde que se in‐trodujo en la legislación de Australia, los Estados Unidos y el Reino Unido a principios del siglo XX. Los defensores del salario mínimo justifican la intervención estatal basándose en principios de equidad y bien social, mientras que sus detractores se amparan en la teoría del mercado. En este artículo se examina la influencia de estas dos posiciones ideológicas en la fijación de los salarios, y los consiguientes resultados de una y otra. El objetivo es colmar la falta de estudios comparativos sobre los orígenes, la evolución y los actuales sistemas de reglamentación del salario mínimo en los tres países.
The effects of scar in psychological disorder: A bibliometric analysis from 2003 to 2022
Authors: Wu Jinyao , Zou Juan , Yang Qiuping , Wang Haiting , Tian Huiting , Chen Lingzhi , Ji Zeqi , Zheng Daitian , Li Zhiyang , Xie Yanna 
Published: September 2023

AbstractScars are fibrous tissues that replace normal tissue during the wound healing process. Scarring can lead to low self‐esteem, social impairment, depression, anxiety, and other psychiatric and psychological distress, necessitating a comprehensive understanding of the latest perspectives, topical research, and directions in scarring‐mental health. This is a biblioshiny and VOSviewer based bibliometric analysis study. All data were obtained from the Web of Science, and a total of 664 articles from 2003 to 2022 met the criteria. The last 7 years have been a period of rapid growth in the field, with 2022 having the highest number of articles. The United States is the core country with the highest production and citation rate. The most cited literature was written in 2003 by Van Loey NE et al. Van Loey NE is the most prolific and influential author in this field. The top five popular keywords include “quality of life”, “depression”, “management”, “anxiety”, and “prevalence”. The paper concludes that the current focus of scholars in the field is on the treatment of scars and that multidisciplinary treatment of such patients is worth exploring. These findings provide relevant researchers with the current state of research and possible future directions in this field.
Ultrafast high‐temperature sintering of ZrB2
Authors: Mondal Santanu , Lombard Juan Diego Shiraishi , Gollapudi Sreenivasulu , Tallon Carolina , Li Jie‐Fang , Viehland Dwight 
Published: September 2023

AbstractUltrafast high‐temperature sintering (UHS) is a joule heating method with an extremely high heating rate (∼103–104°C/min). In this work, commercial ZrB2 powders were rapidly densified by UHS to >90% relative density within 60 s in vacuum without pressure. Bulk density improved from 75% to 93% of relative density by increasing the sintering duration from 10 to 60 s. The final grain size increases from 2.7 ± 1.1 to 19.0 ± 8.4 μm when the sintering time increased from 10 to 60 s. X‐ray diffraction and energy‐dispersive spectroscopy show crystalline phase and compositional uniformity in ZrB2 after UHS.
Risk factors, treatment, and outcome in dogs and cats with subdural hematoma and hemispheric collapse after ventriculoperitoneal shunting of congenital internal hydrocephalus
Authors: Farke Daniela , Siwicka Anna K. , Olszewska Agnieszka , Czerwik Adriana , Büttner Kathrin , Schmidt Martin J. 
Published: September 2023

AbstractBackgroundOvershunting and hemispheric collapse are well‐known complications after ventriculoperitoneal shunt (VPS) implantation. Risk factors that predispose to overshunting, treatment options, and prognosis after therapeutic intervention have not been described.Hypothesis/ObjectivesTo identify preoperative risk factors for overshunting, the effect of surgical decompression, and their outcomes.AnimalsSeventy‐five dogs and 7 cats.MethodsRetrospective case cohort study. Age, breed, sex, body weight, number of dilated ventricles, ventricle brain ratio, intraventricular pressure, and implanted pressure valve systems were evaluated as possible risk factors.ResultsOvershunting had a prevalence of 18% (Cl 95% 9.9‐26.66). An increase of 0.05 in VBR increased the risk of overshunting by OR 2.23 (Cl 95% 1.4‐3.5; P = .001). Biventricular hydrocephalus had the highest risk for overshunting compared to a tri‐ (OR 2.48 with Cl 95% 0.5‐11.1) or tetraventricular hydrocephalus (OR 11.6 with Cl 95% 1.7‐81.1; P = .05). There was no influence regarding the use of gravitational vs differential pressure valves (P > .78). Overshunting resulted in hemispheric collapse, subdural hemorrhage, and peracute deterioration of neurological status in 15 animals. Subdural hematoma was removed in 8 dogs and 2 cats with prompt postoperative improvement of clinical signs.Conclusions and Clinical ImportanceBiventricular hydrocephalus and increased VBR indicate a higher risk for overshunting. The use of differential valves with gravitational units has no influence on occurrence of overshunting related complications and outcomes. Decompressive surgery provides a favorable treatment option for hemispheric collapse and has a good outcome.
Primary intraosseous carcinoma arising in a dentigerous cyst: A case report
Authors: Tousi Farnoush , Johannessen Anne Christine , Ljøkjel Borghild , Løes Sigbjørn 
Published: September 2023

AbstractDentigerous cysts are among the most common cysts of the jaw. They are attached to the crown of an unerupted tooth, most frequently third molars and maxillary canines. They are often asymptomatic and may therefore be diagnosed late. We report a case of a primary intraosseous carcinoma arising from the wall of a dentigerous cyst and describe the expression of typical genes associated with tumour growth and prognosis. The tumour expressed cytokeratins (CK) 5/6, 8, 14 and 19, but not CK7. Ki‐67 and P53 were upregulated in dysplastic epithelium and tumour tissue. Although rare, the possibility for tumour development in the wall of a common cyst should be considered. The case emphasizes the importance of histopathological examination of surgical specimens, even if the clinical diagnosis seems obvious.
The Genetic Causal Association between Educational Attainment and Risk of 12 Common Musculoskeletal Disorders: A Two‐Sample Mendelian Randomization
Authors: Sun Kaibo , Ming Yue , Wu Yuangang , Zeng Yi , Xu Jiawen , Wu Limin , Li Mingyang , Shen Bin 
Published: September 2023

ObjectiveIn numerous observational studies, there has been an indication that educational attainment (EA) can impact the intensity of pain and disability resulting from chronic musculoskeletal disorders. Nonetheless, the association observed in these studies is not entirely conclusive. The aim of this study was to investigate the genetic causal relationship between educational attainment and 12 musculoskeletal disorders using Mendelian randomization (MR).MethodsThe meta‐analysis of genome‐wide association studies (GWAS) identified 3952 single‐nucleotide polymorphisms (SNPs) associated with educational attainment (EA) from the Social Science Genetic Association Consortium (SSGAC). Genetic data for 12 musculoskeletal disorders, including osteonecrosis, osteoporosis, osteomyelitis, low back pain, gout, spinal stenosis, rheumatoid arthritis, meniscus derangement, rotator cuff syndrome, ankylosing spondylitis, cervicobrachial syndrome, and lateral epicondylitis, were obtained from the FinnGen consortium. We conducted a two‐sample Mendelian randomization analysis to examine the causal effect of EA on the risk of these musculoskeletal disorders using the TwoSampleMR package in R.ResultsBased on the inverse‐variance weighted (IVW) method, we found that a genetically predicted per standard deviation (SD) increase in EA was inversely associated with low back pain [odds ratio (OR) 0.46, 95% confidence interval (Cl) 0.51–0.61, p < 0.001], spinal stenosis (OR 0.62, 95% Cl 0.54–0.71, p < 0.001), rheumatoid arthritis (OR 0.65, 95% Cl 0.55–0.76, p < 0.001), meniscus derangement (OR 0.73, 95% Cl 0.65–0.82, p < 0.001), rotator cuff syndrome (OR 0.55, 95% Cl 0.49–0.61, p < 0.001), cervicobrachial syndrome (OR 0.50, 95% Cl 0.42–0.60, p < 0.001), and lateral epicondylitis (OR 0.30, 95% Cl 0.24–0.37, p < 0.001). There was no causal association between EA and osteonecrosis (OR 1.11, 95% CI 0.76–1.72, p = 0.60), osteoporosis (OR 0.91, 95% CI 0.65–1.27, p = 0.59), or osteomyelitis (OR 0.90, 95% CI 0.75–1.01, p = 0.22). Genetic predisposition to EA had a suggestive causal association with gout (OR 0.80, 95% CI 0.68–0.95, p = 0.01) and ankylosing spondylitis (OR 0.64, 95% CI 0.45–0.91, p = 0.01) after Bonferroni correction. None of the analyses revealed any horizontal pleiotropy or heterogeneity.ConclusionIn our investigation, we have uncovered evidence supporting a causal relationship between low level of EA and the incidence of certain musculoskeletal disorders. In the future, it is imperative to ascertain risk factors such as lifestyle patterns linked with EA to uncover the underlying causal relationship and offer informed interventions for individuals.
Development of KASP fingerprinting panel for clonal identification in red raspberry (Rubus idaeus L.)
Authors: Clare Shaun J. , King Ryan M. , Hardigan Michael , Dossett Michael , Montanari Sara , Chagné David , Ochsenfeld Cherie , Britton Caitlin , Rapp Ryan , Bassil Nahla 
Published: September 2023

AbstractRed raspberry is an economically important horticultural crop that is known for its fruit's sweet flavour and nutritional value. A reliable and economic genotyping platform is needed to facilitate clonal/variety identification. Previous attempts for clonal identification utilized morphological traits or low‐throughput, difficult to score dinucleotide‐containing simple sequence repeat molecular markers. Single nucleotide polymorphisms (SNPs), despite having lower allelic diversity, are numerous across the genome and more easily converted to high‐throughput assays restoring differential power. In this study, we use the kompetitive allele‐specific PCR (KASP™) chemistry, an affordable and high‐throughput platform, to develop a panel of SNPs to distinguish a diverse collection of red raspberry accessions for clonal identification. The panel consists of 48 KASP assays that show high concordance with whole genome sequencing, allelic balance, and recovery rate and a minimal set of 24 assays that distinguished the same accessions differentiated by the larger panel.
The shifting roles and toxicities of cellular therapies in B‐cell malignancies
Authors: Makos Olivia L. , D'Angelo Christopher R. 
Published: September 2023

AbstractCellular therapies provide a curative‐intent option for patients with relapsedand refractory lymphomas. Current options including high dose chemotherapyfollowed by autologous or allogeneic hematopoietic stem cell transplantation or CD19 chimericantigen receptor T‐cell (CART) therapy. The indication varies according to lymphoma sub‐type and line oftherapy. The sequencing of these therapies and their use in second‐line orlater settings to manage these diseases is undergoing significant changes, withCD19 CAR T becoming a preferred option for relapsed aggressive B‐cell lymphoma.The mechanism of both therapies causes significant yet distinctlymphodepletion, infectious, and inflammatory toxicities. The resulting patternand timing of immune reconstitution helps guide risk‐mitigating strategies,revaccination, and infectious prophylaxis. In this review, we discuss theindication, efficacy, toxicity and immune reconstitution of autologoushematopoietic stem cell transplantation and CAR T therapy for use in thetreatment of lymphoma.
Letermovir for pre‐emptive cytomegalovirus therapy after allogeneic hematopoietic cell transplantation
Authors: Kaur Raena , Purtill Duncan , Cooney Julian , Cannell Paul , Wright Matthew , Copeland Tandy‐Sue , McGuire Matthew , Boan Peter 
Published: September 2023

AbstractBackgroundCytomegalovirus (CMV) is a common cause of morbidity after allogeneic haematopoietic cell transplantation (alloHCT). Pre‐emptive therapy (PET) with valganciclovir (VGC) is associated with haematological toxicity.MethodsWe included alloHCT patients from 2018 to 2021 where letermovir (LTV) was used for CMV PET because of cytopenias.ResultsTen patients were included. Six received VGC prior to LTV. VGC was commenced at median d42, given for median 40 days. LTV was commenced at median d90, given for median 54 days. At commencement of antiviral, CMV viral load was higher for VGC at 3.7 log10 IU/mL, compared to LTV at 2.9 log10 IU/mL. Viral load reduction occurred at 0.18 log10 IU/mL per week for VGC, compared to 0.17 log10 IU/mL per week for LTV. There was no clinically significant CMV viremia after stopping LTV. Cytopenias improved on LTV.ConclusionLTV was effective in controlling CMV viremia when it was given at a lower starting CMV viral load and later post alloHCT than VGC. Further study is required of LTV as upfront PET following alloHCT.
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Juvenile ocular abnormalities in a litter of black‐footed ferrets
Authors: Chan Kore , Climans Megan , Helmick Kelly , Garelle Della , Adkins Elizabeth A. 
Published: September 2023

AbstractObjectiveTo describe the clinical and histopathological features of ocular abnormalities noted in a litter of black‐footed ferrets (Mustela nigripes), including corneal opacification, cataracts, persistent pupillary membranes, microphthalmia, symblepharon and anterior segment malformation.Animals StudiedA litter of eight black‐footed ferrets examined at 10 weeks old with a history of ophthalmia neonatorum first noted at 7 days old and histopathological examination of three globes from three ferrets of the same litter between 5 and 7 months old following routine subconjunctival enucleation.ProceduresDue to the fractious nature of black‐footed ferrets, slit‐lamp biomicroscopic examination was performed under general isoflurane anesthesia at 10 weeks of age. Corneal opacification was noted in 9/16 eyes, cataracts in 4/16 eyes, and persistent pupillary membranes in 3/16 eyes, among other findings. Histopathology revealed persistent pupillary membranes and Descemet's membrane abnormalities consistent with congenital anterior segment malformation in all three globes. In one ferret, a posterior cortical cataract with posterior lenticular malformation and lens capsule discontinuity was noted. Purulent discharge was cultured at time of enucleation in one ferret with growth of E. coli.ConclusionsA novel constellation of ocular malformations with primary congenital and secondary to ophthalmia neonatorum etiologies is described in black‐footed ferrets. Due to endangered status of black‐footed ferrets, small genetic pool and the requirement for adequate vision for wild‐release, congenital ocular abnormalities such as anterior segment malformation and likely the cataracts described are of particular concern. Further investigation and monitoring are warranted to determine the heritability of these ocular abnormalities.