bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of fear of hypoglycaemia on sleep in adolescents with type 1 diabetes
Authors: Hitt Talia A. , Hershey Jennifer A. , Olivos‐Stewart Diana , Forth Emily , Stuart Fiona , Garren Patrik , Mitchell Jonathan , Hawkes Colin P. , Willi Steven M. , Gettings Julie M. 
Published: February 2023

AbstractAimsFear of hypoglycaemia (FOH) can contribute to impaired sleep for adults with type 1 diabetes (T1D) and parents of children with T1D, although it is unknown how FOH may affect sleep for adolescents with T1D. This study examines the relationship between adolescent FOH and sleep and assessed the influences of continuous glucose monitor (CGM) and insulin pump use.MethodsAdolescents ages 14–18 years with T1D completed questionnaires evaluating FOH (Child Hypoglycemia Fear Survey) and sleep (Pittsburgh Sleep Quality Index, PSQI). Analyses included linear and logistic regression, t‐tests and Fisher's exact tests.ResultsParticipants included 95 adolescents (52 female) with a median (IQR) age of 16.5 (15.3–17.7) years and a T1D duration of 5.7 (2.5–9.6) years. Analyses showed increased FOH‐Worry subscale scores were associated with reduced sleep duration (β = −0.03, p = 0.042, adjusting for BMI z‐score, race and ethnicity) and increased sleep disturbances (OR = 1.1, p = 0.038, adjusting for race and ethnicity). Frequent CGM users had longer sleep duration (average 7.5 h) compared with infrequent or non‐CGM users (average = 6.8 h; p = 0.029), and pump users had overall improved sleep health as determined by PSQI score (p = 0.019). Technology use did not have significant interactions in the relationships between FOH and sleep duration or sleep disturbances.ConclusionsWorrying about hypoglycaemia was associated with impaired sleep for adolescents with T1D. Diabetes technology users have some sleep improvements, but CGM and pump use do little to alter the relationship between FOH and sleep outcomes.
The importance of targeting multiple risk markers in patients with type 2 diabetes: A post‐hoc study from the CANVAS programme
Authors: Tye SokCin , Oshima Megumi , Arnott Clare , Neuen Brendon L. , Fletcher Robert A. , Neal Bruce , Heerspink Hiddo J. L. 
Published: February 2023

AbstractAimsTo investigate the extent to which improvements in multiple cardiovascular risk markers are associated with a lower risk of cardiovascular and kidney outcomes in patients with type 2 diabetes and high cardiovascular risk participating in the CANVAS programme.Materials and methodsClinically relevant improvements in cardiovascular risk factors were defined as a reduction in glycated haemoglobin ≥1.0%, systolic blood pressure ≥10 mmHg, body weight ≥3 kg, urinary‐albumin‐creatinine ratio ≥30%, uric acid ≥0.5 mg/dl, and an increase in haemoglobin of ≥1.0 g/dl from baseline to week 26. Participants were categorized according to the number of improvements in cardiovascular risk markers: zero, one, two, three, or four or more risk marker improvements. The Cox proportional hazard regression adjusted for treatment assignment, demographic variables and laboratory measurements was performed to determine the association between the number of risk marker improvements and risk of a composite cardiovascular, heart failure or kidney outcomes.ResultsWe included 9487 (93.5%) participants with available data at baseline and week 26. After week 26, 566 composite cardiovascular, 370 heart failure/cardiovascular death and 153 composite kidney outcomes occurred. The multivariable adjusted hazard ratios associated with four or more improvements in risk markers versus no risk marker improvement were 0.67 (95% CI 0.48, 0.92), 0.58 (95% CI 0.39, 0.87) and 0.49 (95% CI 0.25, 0.96) for the three outcomes respectively. We observed a trend of decreased hazard ratios across subgroups of increasing number of risk marker improvements (p for trend = .008, .02 and .047, respectively).ConclusionsIn patients with type 2 diabetes, improvements in multiple risk markers were associated with a reduced risk of cardiovascular and kidney outcomes as compared with no risk marker improvement.
Fostering Empathy in Global Citizenship Education: Necessary, Desirable, or Simply Misguided?
Authors: Risberg Eirik Julius 
Published: February 2023

AbstractIn an increasingly globalized world, empathy has been identified as a core competency of future global citizens and thus as an important skill to be fostered in global citizenship education (GCE). Despite this, however, what empathy is, and how it can play the pivotal role often claimed for it in the literature, have not been adequately explored. Here, Eirik Risberg argues that, pace the common conception of empathy, empathy should not be construed narrowly, as an affective concept, but broadly, as a cognitive and epistemic concept. Drawing on recent work in philosophy and psychology, Risberg explores a suggestion that construes empathy as a complex self‐directed perspective‐taking of the situation of another. While this may constitute a conception of empathy that is more modest than the most ardent proponents of empathy would like, it has the benefit of avoiding the objections that have been leveled against empathy as a moral concept and thus allows us to maintain that empathy is a valuable skill to be cultivated in educating global citizens for the twenty‐first century.
Proportional processing of a visual mate choice signal in the green swordtail, Xiphophorus hellerii
Authors: Caves Eleanor M. , Kelley Laura A. 
Published: February 2023

AbstractDuring mate choice, receivers often assess the magnitude (duration, size, etc.) of signals that vary along a continuum and reflect variation in signaller quality. It is generally assumed that receivers assess this variation linearly, meaning each difference in signalling trait between signallers results in a commensurate change in receiver response. However, increasing evidence shows receivers can respond to signals non‐linearly, for example through Weber's Law of proportional processing, where discrimination between stimuli is based on proportional, rather than absolute, differences in magnitude. We quantified mate preferences of female green swordtail fish, Xiphophorus hellerii, for pairs of males differing in body size. Preferences for larger males were better predicted by the proportional difference between males (proportional processing) than the absolute difference (linear processing). This demonstration of proportional processing of a visual signal implies that receiver perception may be an important mechanism selecting against the evolution of ever‐larger signalling traits.
Consumer sentiment analysis with aspect fusion and GAN‐BERT aided adversarial learning
Authors: Jain Praphula Kumar , Quamer Waris , Pamula Rajendra 
Published: February 2023

AbstractThe sentiment analysis (SA) from the user‐generated reviews is the latest research topic in natural language processing. Nowadays, the extraction of consumer sentiment from the content of the consumer reviews is getting much attention because of its importance in understanding consumers' experiences regarding services or products. Consumer sentiment may be helpful for both consumers and organizations; a consumer can refer to previous consumers' feedback while making their purchase decisions, and organizations can use it in service improvements. For the consumer SA, this article proposed the BERT‐GAN model with review aspect fusion, which improves the fine‐tuning performance of the BERT model by introducing semi‐supervised adversarial learning. For our objective, we extracted various service aspects from consumer reviews and fused them with the word sequences before feeding them into the model. That helps in incorporating aspect representation as well as position information in context with the sentences. Our results analysis and their demonstration show the contribution of the presented model in terms of accuracy compared with the existing models found in the previous work.
A survey of clustering large probabilistic graphs: Techniques, evaluations, and applications
Authors: Danesh Malihe , Dorrigiv Morteza , Yaghmaee Farzin 
Published: February 2023

AbstractGiven the growth of uncertainty in the real world, analysing probabilistic graphs is crucial. Clustering is one of the most fundamental methods of mining probabilistic graphs to discover the hidden patterns in them. This survey examines an extensive and organized analysis of the clustering techniques of large probabilistic graphs proposed in the literature. First, the definition of probabilistic graphs and modelling them are introduced. Second, the clustering of such graphs and their challenges, such as uncertainty of edges, high dimensions, and the impossibility of applying certain graph clustering techniques directly, are expressed. Then, a taxonomy of clustering approaches is discussed in two main categories: threshold‐based and possible worlds‐based methods. The techniques presented in each category are explained and examined. Here, these methods are evaluated on real datasets, and their performance is compared with each other. Finally, the survey is summarized by describing some of the applications of probabilistic graph clustering and future research directions.
Increased expression of CEP72 predicts poor prognosis in multiple myeloma
Authors: Guo Dan , Lu Jinfeng , Ji Hao , Lin Zenghua , Hong Lemin , Huang Hongming , Liu Hong 
Published: February 2023

AbstractIntroductionMultiple myeloma (MM) is a fatal hematological malignancy and does not have adequate prognostic indicators. Previous studies indicate that CEP72 is closely related to tumorigenesis and tumor progression. However, the expression and function of CEP72 in multiple myeloma have yet to be elucidated.MethodsIn this study, we explored the correlation between CEP72 expression and clinicopathological characteristics as well as the impacts of CEP72 expression on the survival of MM patients. In addition, PPI, GSEA and Chemotherapy drug resistance analysis identified the possible mechanism.ResultsCEP72 is overexpressed in both MM patients and MM cell lines. Clinically, patients in the CEP72high subgroup were significantly older than those in the CEP72low subgroup (p = 0.003). Up‐regulation of CEP72 was related to poor overall survival and event‐free survival. PPI network showed that CEP72 was related to PCM1, KIZ, OFD1, etc. GSEA analysis showed that CEP72 was enriched in cell cycle, oocyte meiosis, protein export, lysosome and N‐glycan biosynthesis pathways. Drug resistance analysis indicated that there was a positive correlation between the CEP72 expression and the IC50 values of 6‐mercaptopurine, 8‐chloro‐adenosine, clofarabine, fludarabine and allopurinol.ConclusionHigh CEP72 expression was a poor prognostic factor in patients diagnosed with multiple myeloma.
Exosomes for angiogenesis induction in ischemic disorders
Authors: Moeinabadi‐Bidgoli Kasra , Rezaee Malihe , Hossein‐Khannazer Nikoo , Babajani Amirhesam , Aghdaei Hamid Asadzadeh , Arki Mandana Kazem , Afaghi Siamak , Niknejad Hassan , Vosough Massoud 
Published: February 2023

AbstractIschaemic disorders are leading causes of morbidity and mortality worldwide. While the current therapeutic approaches have improved life expectancy and quality of life, they are unable to “cure” ischemic diseases and instate regeneration of damaged tissues. Exosomes are a class of extracellular vesicles with an average size of 100–150 nm, secreted by many cell types and considered a potent factor of cells for paracrine effects. Since exosomes contain multiple bioactive components such as growth factors, molecular intermediates of different intracellular pathways, microRNAs and nucleic acids, they are considered as cell‐free therapeutics. Besides, exosomes do not rise cell therapy concerns such as teratoma formation, alloreactivity and thrombotic events. In addition, exosomes are stored and utilized more convenient. Interestingly, exosomes could be an ideal complementary therapeutic tool for ischemic disorders. In this review, we discussed therapeutic functions of exosomes in ischemic disorders including angiogenesis induction through various mechanisms with specific attention to vascular endothelial growth factor pathway. Furthermore, different delivery routes of exosomes and different modification strategies including cell preconditioning, gene modification and bioconjugation, were highlighted. Finally, pre‐clinical and clinical investigations in which exosomes were used were discussed.
Significant improvement in melanoma survival over the last decade: A Hungarian nationwide study between 2011 and 2019
Authors: Liszkay Gabriella , Benedek Angela , Polgár Csaba , Oláh Judit , Holló Péter , Emri Gabriella , Csejtei András , Kenessey István , Polányi Zoltán , Knollmajer Kata , Várnai Máté , Vokó Zoltán , Nagy Balázs , Rokszin György , Fábián Ibolya , Barcza Zsófia , Gyulai Rolland , Kiss Zoltan 
Published: February 2023

AbstractBackgroundRecent real‐world studies have reported significant improvements in the survival of malignant melanoma in the past few years, mainly as a result of modern therapies. However, long‐term survival data from Central Eastern European countries such as Hungary are currently lacking.MethodsThis nationwide, retrospective study examined melanoma survival in Hungary between 2011–2019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Crude overall survival and age‐standardized 5‐year net survival as well as the association between age, sex and survival were calculated.ResultsBetween 2011 and 2019, 22,948 newly diagnosed malignant melanoma cases were recorded in the NHIF database (47.89% male, mean age: 60.75 years (SD: ±16.39)). Five‐year overall survival was 75.40% (women: 80.78%; men: 69.52%). Patients diagnosed between 2017–2019 had a 20% lower risk of mortality compared to patients diagnosed between 2011–2012 (HR 0.80, 95% CI 0.73–0.89; p < 0.0001). Age‐standardized 5‐year net survival rates in 2011–2014 and 2015–2019 were 90.6% and 95.8%, respectively (women: 93.1% and 98.4%, men: 87.8% and 92.7%, respectively). The highest age‐standardized 5‐year net survival rates were found in the 0–39 age cohort (94.6% in the 2015–2019 period).ConclusionHungary has similar melanoma survival rates to Western European countries. Based on net survival, the risk of dying of melanoma within 5 years was cut by more than half (55%) during the study period, which coincides with the successful implementation of awareness campaigns and the wide availability of modern therapies.
A new multi‐criteria framework to identify optimal detention ponds in urban drainage systems
Authors: Hosseinzadeh Azadeh , Behzadian Kourosh , Rossi Pekka , Karami Mozhgan , Ardeshir Abdollah , Torabi Haghighi Ali 
Published: February 2023

AbstractUrban development broadly impacts the hydrological cycle, leading to increased peak flow and flooding. Surface water detention ponds are among the most efficient measures for attenuating peak flow and returning it from development to pre‐development conditions. However, the major challenge is identifying optimal locations and cost‐effective designs for these ponds. This paper presents a new framework for identifying the best strategies for using detention ponds to control floods in urban drainage systems (UDS). The framework comprises a portfolio of simulation tools coupled with evolutionary optimisation and multi‐criteria decision analysis models. Hydraulic simulation of UDS is first modelled using SWMM and GIS tools. A multi‐objective optimisation model was used to find the optimal location and design for detention ponds. The compromise programming (CP) multi‐criteria decision‐making method was then used to prioritise potential best management solutions for detention ponds based on several sustainability criteria comprising economic, environmental, physiographic and social factors. The results identified the key features of potential detention ponds appearing in all multi‐objective optimal solutions that are useful for decision‐makers/designers when planning/designing for new detention ponds. The selected optimal pond strategies can significantly improve the UDS performance by decreasing flood damage between 66% and 90% at the cost of between $50,000 and $160,000.
Effect of germicidal short wavelength ultraviolet light on the polyphenols, vitamins, and microbial inactivation in a highly opaque apple juice
Authors: Akwu Anita Scales , Patras Ankit , Pendyala Brahmaiah , Kurup Anjali H. , Chen Fur‐Chi , Boushra Markous , Khalil Matthew , Vergne Matthew J. 
Published: February 2023

AbstractThe aim of this investigation was to study the efficacy of UV‐C light emitting diode (LED) system operating at 263 nm for the inactivation of Listeria monocytogenes and Escherichia coli O157:H7. UV‐C irradiation was applied to stirred 5 ml samples, using a collimated beam LED system operating at a 263 nm wavelength. UV irradiation doses ranging from 0 to 160 mJ/cm2 were also delivered to apple juice (AJ) and polyphenols and vitamins were profiled. Liquid chromatography–mass spectrometry (LC–MS/MS) analysis was conducted to assess the stability of polyphenols or vitamins in UV‐C exposed AJ. The polyphenol and vitamin results demonstrated that UV‐C irradiation in AJs at relevant commercial UV doses induced significant reductions in the concentrations of selected polyphenols and vitamins, p < .05. Ascorbic acid was reduced to 32%, at 160 mJ/cm2 whereas 17% reduction was observed at 40 mJ/cm2. Riboflavin was observed to be relatively stable. Epicatechin and chlorogenic were significantly reduced at high exposure doses. In contrast, minor changes were observed at 40 mJ/cm2. Results show that UV‐C irradiation effectively inactivated pathogenic microbes in AJ. Inactivation levels of all organisms were proportional to UV‐C dose. The log reduction kinetics of microorganisms followed log‐linear and with higher R2 (>0.95). The decimal reduction dose (D10) values of 4.16 and 3.84 mJ/cm2 were obtained from the inactivation of E. coli and L. monocytogenes in AJ. The results from this study imply that adequate log reduction of pathogens is achievable in AJ and suggests significant potential for UV‐C treatment of other opaque liquid foods.
Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Authors: Akgün Kathleen M. , Krishnan Supriya , Tate Janet , Bryant Kendall , Pisani Margaret A. , Lo Re Vincent , Rentsch Christopher T. , Crothers Kristina , Gordon Kirsha S. , Justice Amy C. ,   for the VACS project team
Published: February 2023

AbstractBackgroundPeople aging with and without HIV (PWH and PWoH) want to avoid neurocognitive dysfunction, especially delirium. Continued use of alcohol in conjunction with neurocognitively active medications (NCAMs) may be a largely underappreciated cause, especially for PWH who experience polypharmacy a decade earlier than PWoH. We compare absolute and relative risk of delirium among PWH and PWoH by age, level of alcohol use, and exposure to NCAMs.MethodsUsing the VACS cohort, we compare absolute and relative risk of inpatient delirium among PWH and PWoH by age, level of alcohol use, and exposure to NCAMs between 2007 and 2019. We matched each case based on age, race/ethnicity, sex, HIV, baseline year, and observation time with up to 5 controls. The case/control date was defined as date of admission for cases and the date corresponding to the same length of time on study for controls. Level of alcohol use was defined using Alcohol Use Disorder Identification Test–Consumption (AUDIT‐C). Medication exposure was measured from 45 to 3 days prior to index date; medications were classified as anticholinergic NCAM, non‐anticholinergic NCAM, or non NCAM and counts generated. We used logistic regression to determine odds ratios (ORs) for delirium associated with medication counts stratified by HIV status and adjusted for demographics, severity of illness, and related diagnoses.ResultsPWH experienced a higher incidence of delirium (5.6, [95% CI 5.3–5.9/1000 PY]) than PWoH (5.0, [95% CI 4.8–5.1/1000 PY]). In multivariable analysis, anticholinergic and non‐anticholinergic NCAM counts and level of alcohol use demonstrated strong independent dose–response associations with delirium.ConclusionsDecreasing alcohol use and limiting the use of neurocognitively active medications may help decrease excess rates of delirium, especially among PWH.
Cardiac effects of multisystem inflammatory syndrome in children: One‐year follow‐up
Authors: Özgür Gündeşlioğlu Özlem , Subaşı Berivan , Pişkin Ferhat , Atmış Anıl , Demir Fadli , Erdem Sevcan , Alabaz Derya , Çay Ümmühan , Tapaç Nisanur , Kılınç Fatma , Kaymaz Selime T , Özgür Horoz Özden , Yıldızdaş Rıza D , Ünal İlker 
Published: February 2023

AimCardiovascular involvement is common among children with multisystem inflammatory syndrome (MIS‐C) and can cause shock and death. In this study, we evaluated the early and long‐term cardiac effects of MIS‐C.MethodsIn this observational cohort study, we included all children treated for MIS‐C from October 2020 to November 2021 in the Department of Paediatric Infectious Disease at Cukurova University School of Medicine Hospital. The patients underwent serial echocardiographical evaluation during hospitalisation and at 1, 3, 6 and 12 months after discharge. The patients were evaluated using Holter monitorisation between 4 and 6 months and using cardiac magnetic resonance imaging at 6 months and thereafter.ResultsTwenty‐six patients diagnosed with MIS‐C and with a median age of 84 months were included. Cardiac involvement was found in 19 (73.1%) patients. At initial echocardiographic evaluation, the mean ejection fraction value of the patients was 56.7% (range: 30–75). Coronary artery dilatation was detected in two (7.7%) patients, and mitral regurgitation persisted in only one patient by month 3. Treatment was started in two (7.7%) patients due to ventricular arrhythmia. Cardiac magnetic resonance imaging was performed in 13 (50%) patients at a median of 6 months (range: 5–9). The cardiac magnetic resonance imaging findings were consistent with possible interstitial fibrosis in two (7.7%) patients.ConclusionOur results showed that cardiac involvement of patients improved rapidly with treatment, as indicated by previous studies. However, during the 1‐year follow‐up, frequent extraventricular systole was detected in two patients, one of whom initially did not show cardiac involvement. Moreover, possible interstitial fibrosis was detected in the cardiac magnetic resonance imaging (MRI) evaluation of two patients. In particular, we believe that these findings may be useful to evaluate critically ill paediatric patients and patients with severely low EF with cardiac MRI in their follow‐up.