bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Antenatal Care Facility Readiness and Provision of Care at the Individual and Facility Level in Five Low- and Middle-Income Countries
Authors: Sheffel Ashley , Carter Emily , Zeger Scott , Munos Melinda K. 
Published: February 2023

Abstract
Background
Despite growing interest in monitoring improvements in quality of care, data on service quality in low-income and middle-income countries (LMICs) is limited. While health systems researchers have hypothesized the relationship between facility readiness and provision of care, there have been few attempts to quantify this relationship in LMICs. This study assesses the association between facility readiness and provision of care for antenatal care at the client level and facility level.
Methods
To assess the association between provision of care and various facility readiness indices for antenatal care, we used multilevel, multivariable random-effects linear regression models. We tested an inflection point on readiness scores by fitting linear spline models. To compare the coefficients between models, we used a bootstrapping approach and calculated the mean difference between all pairwise comparisons. Analyses were conducted at client and facility levels.
Results
Our results showed a small, but significant association between facility readiness and provision of care across countries and most index constructions. The association was most evident in the client-level analyses that had a larger sample size and were adjusted for factors at the facility, health worker, and individual levels. In addition, spline models at a facility readiness score of 50 better fit the data, indicating a plausible threshold effect.
Conclusions
The results of this study suggest that facility readiness is not a proxy for provision of care, but that there is an important association between facility readiness and provision of care. Data on facility readiness is necessary for understanding the foundations of health systems particularly in countries with the lowest levels of service quality. However, a comprehensive view of quality of care should include both facility readiness and provision of care measures.
Extracellular vesicles-derived microRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development
Authors: Li Xiong , Fu Jing , Jiang Wanjun , Zhang Wenbi , Xu Yan , Gu Ruihuan , Qu Ronggui , Zou Yaoyu , Li Zhichao , Sun Yijuan , Sun Xiaoxi 
Published: February 2023

Abstract
Background
Previous work indicated that the implantation and pregnancy rates of women with endometriosis are lower than those of healthy women during in-vitro fertilisation and embryonic transfer. And there are numerous miRNAs in human uterine luminal fluid (ULF), some of which are associated with early preimplantation development of embryos. In our study, we sought to determine whether microRNAs (miRNAs) in the ULF are differentially expressed between women with and without endometriosis and to uncover the association of miRNAs with the development potential of blastocysts.
Methods
In this case-controlled study, 30 ULF samples were collected each from women with and without endometriosis between March 2018 and May 2019, respectively. TaqMan human miRNA cards and quantitative reverse transcription polymerase chain reaction were used to identify differentially expressed ULF microRNAs between the two groups. Furthermore, the role of miR-145-5p-enriched EVs in mouse and human early embryos was investigated by co-incubation with or without corresponding microRNA-mimic oligonucleotide-enriched EVs, and the effect of miR-145-5p upregulation was investigated on Notch/NOTCH signalling genes.
Results
The implantation and clinical pregnancy rates significantly decreased in women with endometriosis than in those without endometriosis. Notably, hsa-miR-145-5p was upregulated in ULF samples from women with endometriosis (fold change > 2, false discovery rate < 0.001). Moreover, the ratios of mouse/human early embryos that developed into blastocyst-staged embryos (P = 0.0037 and P = 0.0079, respectively) were significantly affected via miR-145-5p upregulation in mouse/human early embryos. Notch signalling pathway components had abnormal expression levels in the mouse/human blastocyst-stage embryos in the miR-145-5p mimic-enriched EVs group.
Conclusions
Our study revealed that human extracellular vesicle-derived microRNAs in ULF impacted the developmental potential of blastocysts in women with endometriosis. Moreover, the upregulation of miR-145-5p-enriched EVs in mouse and human embryos negatively affected blastocyst development by suppressing the expression of components of the NOTCH signalling pathway, which may contribute to elucidate the cause of infertility in women with endometriosis.
Non-invasive super-resolution imaging through scattering media using object fluctuation
Authors: Dang Cuong , Zhu Xiangwen , Sahoo Sujit , Tobing Landobasa Y.M. , Adamo Giorgio , Zhang Dao Hua 
Published: February 2023

Abstract
Introducing super-resolution techniques to imaging through scattering media potentially revolutionizes the technical analysis for many exotic applications, such as cell structures behind biological tissues. The main challenge is scattering media’s inhomogeneous structures, which scramble the light path and create noise-like speckle patterns, hindering the object’s visualization even at a low-resolution level. Here, we propose a computational method relying on the object’s spatial and temporal fluctuation to visualize nanoscale objects through scattering media non-invasively. Taking advantage of the optical memory effect and multiple frames, we estimate the point spreading function (PSF) of the scattering media. Multiple images of the fluctuating object are obtained by deconvolution; then, the super-resolution image is achieved by computing the high-order cumulants. Non-linearity of high order cumulant significantly suppresses the artifacts in the resulting images and enhances the resolution by a factor of √N, where N is the cumulant order. Our proof-of-concept demonstration shows 188-nm FWHM feature at 12nd cumulant order, breaking the Rayleigh diffraction limit by a factor of 3.46. Our non-invasive super-resolution speckle fluctuation imaging (NISFFI) presents a nanoscopy technique with straightforward imaging hardware configuration to visualize samples behind scattering media.
Overview of modeling techniques for ecological Connectivity in heterogeneous landscape
Authors: Tiwari Amrapali , Saran Sameer , Avishek Kirti 
Published: February 2023

Abstract
Ecological connectivity in a landscape is one of the crucial factors for biodiversity conservation. Especially in case of large mammals like top carnivores. Frequent environmental changes have resulted in isolated world’s wildlife population which leads to increased pace biodiversity loss. Moreover, Increased human inhabitants and population shift towards the edge of forests provides animals with very less or no scope of living in the wilderness. As a result, ecological connectivity analysis and landscape planning are integral part of one another. This paper reviews the available techniques for quantifying dispersal in the landscape. A critical and thorough review of available theories of wide range of methods, techniques and tools for corridor analysis in conservation scenario is done in this paper. It also compiles various approach utilized globally. An exhaustive discussion on modeling techniques such as graph theoretic approaches (least cost path analysis, network analysis, etc), circuit theoretic approaches, agent based models and machine learning based approach is compiled for improved decision making.
Dynamical analysis of a forced vibrating planar motion of a spring pendulum
Authors: Amer T. S. , Amer Asmaa , Galal Abdallah Abbas 
Published: February 2023

Abstract
This work studies the nonlinear movement of a two degrees-of-freedom (DOF) spring pendulum that is dampened and affected by a torque and harmonic force externally. It is presumed that the spring’s pivot point travels along an elliptic route. Lagrange's equations are utilized to generate the regulating system of motion. The multiple-scales approach (MSA) is used to gain the system’s analytic solutions up to the third approximation. Therefore, all resonance cases that have emerged are categorized, wherein two of them are scrutinized at once. As a result of the removal of secular terms, the solvability constraints are attained and then the steady-state solutions are investigated. The examined motion's temporal evolution, the resonance response curves, and the solutions at the steady-state are all depicted graphically. In compliance with the Routh-Hurwitz criteria (RHC), all possible fixed points (FP) for the cases of steady and unsteady are found and displayed. The stability zones are examined and analysed to estimate the effect of various factors on the system’s behavior. This model has gained prominence recently due to its industrial uses in fields including construction, infrastructure, transportation, and vehicles.
Association of the barriers of pharmaceutical care perceived by clinical pharmacists and occupational stress in tertiary hospitals of China
Authors: Zhang Yu , Xi Xiaoyu , Huang Yuankai 
Published: February 2023

Abstract
Background
As an important member of the health care team, clinical pharmacists' occupational stress will lead to the decline of pharmaceutical care quality. Chinese clinical pharmacists are facing high work pressure. Person-environment fit theory indicated that the barriers of pharmaceutical care may be a potential factor associated with occupational stress. However, in clinical practice, it is unclear whether the perceived barriers of clinical pharmacists affect occupational stress in clinical practice and which barriers will affect.
Objective
This study aimed to assess the association between the specific barriers of pharmaceutical care perceived by clinical pharmacists and their occupational stress in China.
Method
A field questionnaire survey using a stratified sampling was conducted to gather data on occupational stress, barriers of pharmaceutical care perceived by clinical pharmacists, and other factors of occupational stress using the Brief Job Stress Questionnaire and a self-developed instrument. Ordinary least squares regression was used to evaluate the association of the participants’ knowledge, skills, and other factors with their occupational stress.
Results
A total of 625 clinical pharmacists from 311 tertiary hospitals in China (response rate = 84%) participated. Perceived resource dimension (p = 0.00) and self-improvement dimension barriers (p = 0.01) was associated with increased occupational stress of the participants. In addition, clinical pharmacists’ technical titles and specialized field are associated with their occupational stress.
Conclusion
By reducing some specific barriers of pharmaceutical care perceived by clinical pharmacists, the occupational stress can be relieved, so as to improve the quality and efficiency of clinical pharmaceutical care.
The Effect of Sarcopenia on Survival in Patients with Metastatic Colon Cancer
Authors: dogan ozlem , Sahinli Hayriye , zeynelgil esra , simsir begum demirler , imamoglu goksen inanc 
Published: February 2023

Abstract
Introduction: Sarcopenia is a common loss of muscle mass in cancer patients. Our aim in this study is to investigate the effect of sarcopenia on survival in patients with metastatic colon cancer.
Material and Methods: The study was carried out retrospectively in patients diagnosed with metastatic colon cancer between January 2016 and December 2020. Sarcopenic patients were determined by total psoas area index and Hounsfield unit average calculation using computed tomography (CT) scan images obtained at the time of diagnosis.
Results: A total of 70 patients with metastatic colon cancer were evaluated. Sarcopenia was detected in 18 patients (25.7%). The median age of sarcopenic patients was 72 (53-83) years. A significant correlation was found between age and sarcopenia (p=0.002). Median survival of sarcopenic patients was 11 months while non-sarcopenic patients had a median survival of 24 months. A difference was found in overall survival (OS) between the two groups (p=0.021). There was no difference in progression free survival (PFS) between sarcopenic and non-sarcopenic patients.
Conclusions: In our study, a significant prognostic effect of sarcopenia on survival was found in patients with metastatic colon cancer. The survival of sarcopenic patients was poorer.
Problem gambling among people with first-episode psychosis: protocol for a prospective multicenter cohort study
Authors: Corbeil Olivier , Soulard Manuel , Huot-Lavoie Maxime , Béchard Laurent , Fournier Émilien , Brodeur Sébastien , Essiambre Anne-Marie , Desmeules Charles , Thériault Chantale , Abdel-Baki Amal , Jacques Christian , Giroux Isabelle , Dorval Michel , Roy Marc-André , Demers Marie-France 
Published: February 2023

Abstract
Background
The limited available data suggest that the prevalence of problem gambling is increased among young adults with first-episode psychosis, possibly due in part to several risk factors for problem gambling that are common in this population. Aripiprazole, a widely used antipsychotic drug, has also been linked to cases of problem gambling, but causality remains uncertain. Although the consequences of problem gambling further hinder the recovery of people with first-episode psychosis, there is a paucity of research about this comorbidity and its risk factors. Additionally, to our knowledge, no screening instrument for problem gambling tailored to these individuals exists, contributing to its under-recognition. Further, treatment approaches for problem gambling adapted to this population are at an embryonic stage, while existing treatments effectiveness remains to be documented. Using an innovative screening and assessment procedure for problem gambling, this study aims to identify risk factors for problem gambling among people with first-episode psychosis and to document the effectiveness of standard treatment approaches.
Methods
This is a multicenter prospective cohort study conducted in two first-episode psychosis clinics, including all patients admitted between November 1st, 2019, and November 1st, 2023, followed for up to 3 years until May 1st, 2024. These 2 clinics admit approximately 200 patients annually, for an expected sample size of 800 individuals. The primary outcome is the occurrence of a DSM-5 diagnosis of gambling disorder. All patients are screened and evaluated for problem gambling using a systematic procedure at admission, and every 6 months thereafter. Socio-demographic and clinical variables are prospectively extracted from the patients’ medical records. The nature and effectiveness of treatments for problem gambling offered to affected individuals are also documented from medical records. Survival analyses with Cox regression models will be used to identify potential risk factors for problem gambling. Descriptive statistics will document the effectiveness of treatments for problem gambling in this population.
Discussion
A better understanding of potential risk factors for problem gambling among people with first-episode psychosis will allow for better prevention and detection of this neglected comorbidity. Results of this study will also hopefully raise clinicians’ and researchers’ awareness and serve as the basis to adapted treatments that will better support recovery.
Trial registration:
ClinicalTrials.gov, NCT05686772. Retrospectively registered, 9 January 2023.
Substance Abuse Poisoning Registry development: Based on lessons learned from a pilot implementation
Authors: Jebraeily Mohamad , Delirrad Mohammad , Boushehri Behzad , Pahlevanynejad Shahrbanoo , Badali Borhan 
Published: February 2023

Abstract
Background: Substance abuse has been recognized as a national problem in which poisoning with pharmaceutical drugs, opioids and alcohols is a common problem in Iran. Due to the lack of a comprehensive information system related to Substance abuse, despite the systematic information in health services, and to achieve this goal, the purpose of this research was to develop a registry system for substance abuse poisoning in - Urmia University of Medical Sciences.
Methods: This research is a practical development study that was done in 4 phases. In the first phase, minimum data set (MDS) of the system were determined. In the second phase, the registration system was designed. The third phase includes the implementation of the system, and finally, the system was evaluated by QUIS questionnaire.
Results: A total of 58 data elements in 6 classes were recognized as essential for this system from the point of view of experts. The system was implemented on the ASP.NET platform using C# language and SQL Server database in the poisoning department of Taleghani Hospital in Urmia. The evaluation of usability of the system showed score obtained in the 6 main categories were in set of terms of the system 8.52, screen 8.36, ability to learn 8.8, overall functionality 8.04, user interface 7.98, and the overall interaction is 7.73 respectively.
Conclusion: Considering the capabilities of the system for registering poisonings caused by drug abuse, it seems necessary to implement this system in the form of a national network, in order to make the necessary interventions to control drug abuse while using resources efficiently.
Fast and accurate automated intestinal parasites egg detection and classification from images based on YOLOv5 deep convolutional neural network
Authors: Alotaibi Abdullah , Kumar Satish , Arif Tasleem 
Published: February 2023

Abstract
Computer vision based on deep learning has made great stride in resent time. Several deep convolutional neural network based architectures have been built since the first release of the Alexnet model. Meanwhile, very little research on parasitology, specifically intestinal parasites, is being conducted using modern deep learning architecture based on convolutional neural networks. The goal of this research is to evaluate the performance of YOLOv5's state-of-the-art deep-learning architecture for detecting and classifying intestinal parasite eggs from images. We would ensure that patients receive prompt treatment while also relieving experts of extra work if we used such an architecture. Here, in stage first, we applied image pre-processing and augmentation to the dataset, and in stage second, we utilized the YOLOv5 algorithms for detection and classification and then compared their performance based on different parameters. Our algorithms achieved a mean average precision of 97% and 8.5 ms detection time per sample for 2,393 intestinal parasite images. Thus, this approach may form a solid theoretical basis for real-time detection and classification in routine clinical examinations while accelerating the process to satisfy increasing demand.
Preliminary study on the expression of UHRF1 in early oral squamous cell carcinoma and its clinical prognostic value
Authors: Duan Xianjie , Weng Haiyan , Shen Guodong , Si Chengyun , Fei Anxing , Zhang Liyu , Zhou Yu 
Published: February 2023

Abstract
Objectives: To evaluate the expression of ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) in early oral squamous cell carcinoma (OSCC) and explore its clinical significance.
Methods: In total, 104 patients with early OSCC who had undergone surgery in the First Affiliated Hospital of the University of Science and Technology of China from 2008 to 2016 were retrospectively analyzed. The correlation between UHRF1 and vimentin was assessed by evaluating their expression levels in OSCC tissue using immunofluorescence staining. The patients were divided into UHRF1/vimentin high and low expression groups on the basis of an immunoreactivity intensity distribution index value of 4. The relationships between the UHRF1 and vimentin expression levels and the clinic opathological characteristics of patients were analyzed. The influence of relevant risk factors on the patient survival rate was analyzed with the Kaplan– Meier method, whereas the relevant risk factors affecting the survival rate of patients with oral cancer were analyzed using the Cox proportional hazards model.
Results: High UHRF1 expression was observed in OSCC tissue. Likewise, vimentin was highly expressed in mesenchymal tumor tissue, and its expression level was positively correlated with that of UHRF1 (R2 = 0.2626, P < 0.001). UHRF1 expression was correlated with the patient gender; N stage; T, N stages of the 8th edition of TNM classification; tumor differentiation; occult lymph node metastasis; neck recurrence; and postoperative local recurrence (P < 0.05). Moreover, it was positively correlated with the depth of invasion (R2 = 0.2105, P < 0.001). The vimentin expression level was related to the patient gender, T stage, 8th edition T stage, occult lymph node metastasis, neck recurrence, and local recurrence (P < 0.05). According to the Cox regression model, the UHRF1 expression level of UHRF1 was an influencing factor affecting the survival rate of patients (HR: 2.64; 95 CI%: 1.35–5.15; P = 0.004).
Conclusion: UHRF1 is highly expressed in early OSCC and is closely related to epithelial–mesenchymal transition and the prognosis of patients.
Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway
Authors: Chen Yao , Liu Xudan , Zhang Qianhui , Wang Huanhuan , Zhang Ruo , Ge Yanhong , Liang Huning , Li Wanying , Fan Juanjun , Liu Huimin , Lv Zhengyang , Wang Yi , Li Xin 
Published: February 2023

Abstract
Arsenic contamination of groundwater remains a serious public health problem worldwide. Arsenic-induced neurotoxicity receives increasing attention, however, the mechanism remains unclear. Hippocampal neuronal death is regarded as the main event of arsenic-induced cognitive dysfunction. Mitochondria lesion is closely related to cell death, however, the effects of arsenic on PGAM5-regulated mitochondrial dynamics has not been documented. Crosstalk between autophagy and apoptosis is complicated and autophagy has a dual role in the apoptosis pathways in neuronal cells. In this study, arsenic exposure resulted in mitochondrial PGAM5 activation and subsequent activation of apoptosis and AMPK-mTOR dependent autophagy. Intervention by autophagy activator Rapamycin or inhibitor 3-MA, both targeting at mTOR, accordingly induced activation or inhibition of apoptosis. Intervention by MK-3903 or dorsomorphin, activator or inhibitor of AMPK, received similar results. Our findings suggested that arsenic-induced PGAM5 activation played a role in AMPK-mTOR dependent autophagy and arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway.