bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant peripheral nerve sheath tumor in the pelvis: a case report
Authors: Ono Rika , Tominaga Tetsuro , Nonaka Takashi , Takamura Yuma , Oishi Kaido , Shiraishi Toshio , Hashimoto Shintaro , Noda Keisuke , Sawai Terumitsu , Nagayasu Takeshi 
Published: September 2023

Abstract
Background
Malignant peripheral nerve sheath tumors (MPNSTs) are malignancies that arise or differentiate from or infiltrate peripheral nerves and account for approximately 5% of soft-tissue malignancies. Approximately half of MPNSTs develop in patients with neurofibromatosis type 1 (NF1), a hereditary disease. MPNSTs occur mainly in the trunk, proximal extremities, and neck, but can on rare occasion arise in or near the gastrointestinal tract, and intestinal complications have been reported. We describe herein a case with resection of an MPNST arising in the pelvic region.

Case presentation
A 51-year-old woman had undergone repeated resections for systemic neurofibrosis associated with NF1. This time, a pelvic tumor was noted on follow-up positron emission tomography computed tomography (CT). She presented with slowly progressive radiating pain in the lower extremities and was referred to our hospital for tumor resection. Contrast-enhanced CT showed a 75 × 58-mm mass in the right greater sciatic foramen directly below a 24 × 28-mm mass. Open pelvic tumor resection was performed for pelvic neurofibroma. The obturator nerve was identified lateral to the main tumor and the sciatic nerve was identified dorsally, then dissection was performed. The closed nerve was spared, while the sciatic nerve was partially dissected and the two tumors were removed. Both tumors were elastic and hard. Pathologic findings were MPNST for the large specimen and neurofibroma with atypia for the small specimen. The patient developed temporary postoperative ileus, but is generally doing well and is currently free of recurrence or radiating pain. The patient is at high risk of recurrence and close monitoring should be continued.

Conclusions
We encountered a rare case of MPNST. Due to the high risk of recurrence, surgery with adequate margins was performed, with a requirement for appropriate follow-up.
Use of patient-specific guides and 3D model in scapula osteotomy for symptomatic malunion
Authors: Cattaneo Stefano , Domenicucci Marco , Galante Claudio , Biancardi Elena , Casiraghi Alessandro , Milano Giuseppe 
Published: September 2023

Abstract
Background
Scapular osteotomy for malunion can lead to resolution of pain and functional improvement in scapula fracture sequelae. Understanding three-dimensional bone morphology and analysing post-traumatic deformity is the main step of planning and the key to success of the procedure. 3D models and patient-specific guides are a growing technology to enhance accuracy of planning and to assist during surgery.

Case presentation
We report the case of a 50 years old male, complaining of pain and limited function after a malunited scapular body fracture. Clinical assessment showed a severe impairment of shoulder function with active and passive forward flexion limited to 80°, absent external rotation, and internal rotation limited to the buttock. X-rays and CT scan showed an excessive lateral border offset of 53 mm and complete displacement of the glenoid segment anteriorly and medially to the scapular body, with impingement between the lateral most prominent scapular bone spur and humeral shaft. Glenopolar angle was 19°, scapular body angulation on the sagittal plane was 12°. Corrective osteotomy was planned on a virtual interactive rendering and on 3D printed models. Patient-specific guides were developed to perform a body-spine osteotomy with removal of a bone wedge, and a glenoid-spine osteotomy; a patient-specific wedge spacer was used to hold the reduction during plate fixation. Follow-up up to 12 months after surgery demonstrated improvement in scapula anatomy, shoulder girdle function, and patient-reported outcomes.

Conclusions
For the first time in scapula malunion surgery, patient-specific osteotomy guides were succesfully used during surgery to perform osteotomies and to assist in reduction maneuvers.
Turbulent far wake of a body of arbitrary shape
Authors: Le Berre M. , Pomeau Y. 
Published: September 2023

Abstract
Using a recently proposed closure for the Boussinesq-Reynolds turbulent stress we re-derive Prandtl's result for the turbulent wake width behind blunt bodies. We show that it is valid for a body of arbitrary shape, but only for wakes due to a drag oriented parallel to the incoming flow. If the geometry of the body resisting the flow lacks symmetries forbidding it, the force on the body has also a component orthogonal to the incoming velocity, called lift, that allows, for instance, planes to fly. Using our closure theory we show that this lift generates a wake wider than the drag, with a width growing like the one-half power of the distance to the body, instead of the one-third in the case of drag only. This has important consequences as it leads to a change of structure of the wake that remains turbulent all the way to infinity.
Thyroid Hormone Levels Correlate With the Maturation of Implanted Pancreatic Endoderm Cells in Patients With Type 1 Diabetes
Authors: Ramzy Adam , Saber Nelly , Bruin Jennifer E , Thompson David M , Kim Peter T W , Warnock Garth L , Kieffer Timothy J 
Published: September 2023

Abstract

Background
Macroencapsulated pancreatic endoderm cells (PECs) can reverse diabetes in rodents and preclinical studies revealed that thyroid hormones in vitro and in vivo bias PECs to differentiate into insulin-producing cells. In an ongoing clinical trial, PECs implanted in macroencapsulation devices into patients with type 1 diabetes were safe but yielded heterogeneous outcomes. Though most patients developed meal responsive C-peptide, levels were heterogeneous and explanted grafts had variable numbers of surviving cells with variable distribution of endocrine cells.

Methods
We measured circulating triiodothyronine and thyroxine levels in all patients treated at 1 of the 7 sites of the ongoing clinical trial and determined if thyroid hormone levels were associated with the C-peptide or glucagon levels and cell fate of implanted PECs.

Results
Both triiodothyronine and thyroxine levels were significantly associated with the proportion of cells that adopted an insulin-producing fate with a mature phenotype. Thyroid hormone levels were inversely correlated to circulating glucagon levels after implantation, suggesting that thyroid hormones lead PECs to favor an insulin-producing fate over a glucagon-producing fate. In mice, hyperthyroidism led to more rapid maturation of PECs into insulin-producing cells similar in phenotype to PECs in euthyroid mice.

Conclusion
These data highlight the relevance of thyroid hormones in the context of PEC therapy in patients with type 1 diabetes and suggest that a thyroid hormone adjuvant therapy may optimize cell outcomes in some PEC recipients.
Hyperoxia Increases Kidney Injury During Renal Ischemia and Reperfusion in Mice
Authors: Kimlinger Melissa J. , No Tom J. , Mace Eric H. , Delgado Rachel D. , Lopez Marcos G. , de Caestecker Mark P. , Billings Frederic T. 
Published: September 2023

BACKGROUND:
Renal ischemia and reperfusion (IR) contribute to perioperative acute kidney injury, and oxygen is a key regulator of this process. We hypothesized that oxygen administration during surgery and renal IR would impact postoperative kidney function and injury in mice.

METHODS:
Mice were anesthetized, intubated, and mechanically ventilated with a fraction of inspired oxygen (Fio
2) 0.10 (hypoxia), 0.21 (normoxia), 0.60 (moderate hyperoxia), or 1.00 (severe hyperoxia) during 67 minutes of renal IR or sham IR surgery. Additional mice were treated before IR or sham IR surgery with 50 mg/kg tempol, a superoxide scavenger. At 24 hours, mice were sacrificed, and blood and kidney collected. We assessed and compared kidney function and injury across groups by measuring blood urea nitrogen (BUN, primary end point), renal histological injury, renal expression of neutrophil gelatinase–associated lipocalin (NGAL), and renal heme oxygenase 1 (Ho-1), peroxisome proliferator–activated receptor gamma coactivator 1-α (Pgc1-α), and glutathione peroxidase 4 (Gpx-4) transcripts, to explore potential mechanisms of any effect of oxygen.

RESULTS:
Hyperoxia and hypoxia during renal IR surgery decreased renal function and increased kidney injury compared to normoxia. Baseline median (interquartile range) BUN was 22.2 mg/dL (18.4–26.0), and 24 hours after IR surgery, BUN was 17.5 mg/dL (95% confidence interval [CI], 1.3–38.4; P = .034) higher in moderate hyperoxia–treated animals, 51.8 mg/dL (95% CI, 24.9–74.8; P < .001) higher in severe hyperoxia–treated animals, and 64.9 mg/dL (95% CI, 41.2–80.3; P < .001) higher in hypoxia-treated animals compared to animals treated with normoxia (P < .001, overall effect of hyperoxia). Hyperoxia-induced injury, but not hypoxia-induced injury, was attenuated by pretreatment with tempol. Histological injury scores, renal NGAL staining, and renal transcription of Ho-1 and suppression of Pgc1-α
followed the same pattern as BUN, in relation to the effects of oxygen treatment.

CONCLUSIONS:
In this controlled preclinical study of oxygen treatment during renal IR surgery, hyperoxia and hypoxia impaired renal function, increased renal injury, and impacted expression of genes that affect mitochondrial biogenesis and antioxidant response. These results might have implications for patients during surgery when high concentrations of oxygen are frequently administered, especially in cases involving renal IR.
Live-imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation
Authors: Ward Juma , Martin Paul 
Published: September 2023

ABSTRACT
Previous clinical studies and work in mouse models have indicated that platelets and microclots might enable the recruitment of immune cells to the pre-metastatic cancer niche, leading to efficacious extravasation of cancer cells through the vessel wall. Here, we investigated the interaction between platelets, endothelial cells, inflammatory cells, and engrafted human and zebrafish cancer cells by live-imaging studies in translucent zebrafish larvae, and show how clotting (and clot resolution) act as foci and as triggers for extravasation. Fluorescent tagging in each lineage revealed their dynamic behaviour and potential roles in these events, and we tested function by genetic and drug knockdown of the contributing players. Morpholino knockdown of fibrinogen subunit α (fga) and warfarin treatment to inhibit clotting both abrogated extravasation of cancer cells. The inflammatory phenotype appeared fundamental, and we show that forcing a pro-inflammatory, tnfa-positive phenotype is inhibitory to extravasation of cancer cells.
Weaver ants regulate the rate of prey delivery during collective vertical transport
Authors: Burchill Andrew T. , Pavlic Theodore P. , Pratt Stephen C. , Reid Chris R. 
Published: September 2023

ABSTRACT
The collective transport of massive food items by ant teams is a striking example of biological cooperation, but it remains unclear how these decentralized teams coordinate to overcome the various challenges associated with transport. Previous research has focused on transport across horizontal surfaces and very shallow inclines, disregarding the complexity of natural foraging environments. In the ant Oecophylla smaragdina, prey are routinely carried up tree trunks to arboreal nests. Using this species, we induced collective transport over a variety of angled surfaces with varying prey masses to investigate how ants respond to inclines. We found that weight and incline pose qualitatively different challenges during transport. Prey were carried over vertical and inclined surfaces faster than across horizontal surfaces, even though inclines were associated with longer routes and a higher probability of dropping the load. This additional speed was associated with more transporters being allocated to loads on steeper inclines and not with the persistence of individual ants. Ant teams also regulated a stable prey delivery rate (rate of return per transporter) across all treatments. Our proposed constrained optimization model suggests a possible explanation for these results; theoretically, prey intake rate at the colony level is maximized when the allocation of transporters yields a similar prey delivery rate across loads.
Implementation of a Multi-Disciplinary Team and Quality of Goals of Care Discussions in Palliative Surgical Oncology Patients
Authors: Soon Joel J. Y. , Juan Darryl W. K. , Ong Whee S. , Bek Schin , Neo Patricia S. H. , Salazar Ennaliza , Da Zhuang Kun , Tan Yee Pin , Seo Chin Jin , Ong Johnny C. A. , Chia Claramae S. , Wong Jolene S. M. 
Published: September 2023

Abstract
Background
Palliative surgical oncology patients represent a unique group with complex needs who often require multidisciplinary input for the provision of timely and holistic care. The authors assembled a multi-disciplinary palliative intervention team and evaluated its association with the quality of discussions on goals of care (GOC) among advanced cancer patients undergoing palliative interventions.

Methods
This prospective cohort study analyzed advanced cancer patients undergoing palliative interventions at a single urban academic center from October 2019 to March 2022. In January 2021, a multi-disciplinary palliative surgical intervention (MD-PALS) team was assembled. All palliative surgical oncology patients were discussed at multi-disciplinary meetings and managed by members of the MD-PALS team. An interrupted time series (ITS) model was built to evaluate the association of MD-PALS implementation and the quality of GOC discussions as measured by a consensus-derived four-point GOC discussion quality score.

Results
The study recruited 126 palliative surgical oncology patients: 44 in the pre-MD-PALS group and 82 in the post-MD-PALS group. The two groups did not differ significantly in baseline demographics, treatment, or postoperative and survival outcomes. Compared with the pre-MD-PALS group, the post-MD-PALS group had a significantly higher mean GOC discussion quality score (1.34 vs 2.61; p < 0.001). Based on the ITS model, the average quarterly GOC discussion quality score increased significantly among patients after implementation of the MD-PALS team (change = 1.93; 95 % confidence interval, 0.96–2.90; P = 0.003).

Conclusion
The implementation of an MD-PALS team was associated with improvements in the quality of GOC discussions among palliative surgical oncology patients.
Frozen Shoulder: Diagnosis and Management
Authors: Wise Sean R. , Seales Paul , Houser Alex P. , Weber Chase B. 
Published: September 2023

AbstractFrozen shoulder is a common condition that causes pain and restriction of movement of the shoulder unrelated to secondary causes. It has three classic phases (freezing, frozen, and thawing), and is resolved in most cases within 1 to 2 years. Diagnosis is clinical based on global motion restriction and pain. Imaging plays an ancillary role to narrow the differential diagnosis. Physical therapy, nonsteroidal anti-inflammatories, and injection therapies are standard treatments, although none have been shown to alter the long-term course of the condition. Ultrasound guidance is recommended for injection-based therapy, although not required. Further study should focus on long-term outcomes and treatments that significantly alter the natural course of the disease.
Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel
Authors: Meutia Sari Liza , Mubarak Zaki , Keumala Sari Dina 
Published: September 2023

Background: Areca nut (Areca catechu Linn.) is the seed of the fruit of the oriental palm that is commonly used among Southeast Asian communities. Chrysanthemum (Dendrathema grandiflora) is a flowering plant originating from East Asia and dominantly grows in China. Both of these plants have strong antioxidant activities. To investigate the mechanism of their wound healing activities, we prepared areca nut and chrysanthemum polyethylene oral gel and performed several in vivo assays using Sprague–Dawley rats. Methods: Sprague–Dawley rats were divided into six groups: Negative control group (rats with base gel treatment), positive control group (rats treated with triamcinolone acetonide), F1 (treatment with 20% areca nut:80% chrysanthemum), F2 (treatment with 50% areca nut:50% chrysanthemum), F3 (treatment with 80% areca nut:20% chrysanthemum), and normal group (without ulcer and treatment). Traumatic ulcers were performed on the buccal mucosa of all experimental animals that received topical oral gel and triamcinolone acetonide twice a day for seven days. The clinical and histological characteristics were analyzed and scored. Results: During the six days, the ulcerated area receded linearly over time and was completely cicatrized in F2, F3, and the positive control group (Dependent t-test, p<0.05). There were significant increases in body weight in F2 and positive control groups. There were no significant differences between groups in histology examination (Kruskal Wallis test, p<0.05). The moderate score of TNF-α levels was seen in F2 and positive control groups (ANOVA/Tukey test, p<0.05). In the collagenases assay, a high concentration of areca nut (F3) induced the abundance of collagen during the ulcer healing process. Conclusions: The combination of areca nut and chrysanthemum extract in the oral gel can optimize the healing of traumatic oral ulcers in Sprague-Dawley rats through the increase of TNF-α and collagen deposition.
Automated news in practice: a cross-national exploratory study
Authors: Danzon-Chambaud Samuel 
Published: September 2023

Background: This article provides a comprehensive picture of the current state of automated news—understood here as the auto-generation of journalistic text through software and algorithms—as well as to where it is headed. For this, I look at 18 news organisations in Europe, North America and Australia, following a strategic sample inspired by Hallin and Mancini’s (2004) media system typology. Methods: To conduct this cross-national exploratory study, I made use of semi-structured interviews with editorial staff, executives and technologists. I also rely on Actor-network theory (ANT) to tell when an interference is made to an otherwise linear situation, thus endowing automated news with a sense of agency. Results: Overall, my findings show that the main interferences concern alternate data sources (e.g., news organisations’ internal feeds, crowdsourced material), in-house interfaces that allow for more journalistic participation (e.g., internal self-editing tools, notification streams) and output other than text (e.g., automated audio summaries for voice assistants). Conclusions: Although these changes lead to greater journalistic professionalisation, they could also make news organisations become too dependent on Big Tech companies for data acquisition and dissemination of automated news products. That said, mutual negotiations and a re-alignment of interests may occur as platforms increasingly face journalistic challenges.
The wolf, the lamb, and the big “Oh!”: voids, (w)holes, and epitaphic emptiness in Frances Burney’s Hubert de Vere
Authors: Saggini Francesca 
Published: September 2023

This essay explores the character of Cerulia in Frances Burney’s dramatic play, Hubert de Vere, composed and revised in the 1790s, yet never published or staged in Burney’s lifetime. Cerulia seems to eschew any easy dramatic categorization, as she cannot be identified with the heroine of the play. Undeniably, she is a victim, but of whom/what, we may wonder? Does attempting to define the nature of the hamartia of which Cerulia remains victim lead the “ideal” reader/viewer toward either fate/the gods or, rather, social apparatuses? And, finally, what about the eponymous protagonist Hubert de Vere? Is it correct to identify de Vere as the actant “hero”, or perhaps as per the sub-category “villain hero” so popular in late eighteenth-century dramas? Burney’s adroit exploitation of tropology and literary allusion in Hubert de Vere will be at the centre of this essay. In particular, I will examine the last act of the play, where the themes of confinement, imprisonment, and escape take on tragic hues. Though unpublished until 1995, these scenes are among the most vivid and, indeed, the most shocking Burney ever wrote. It is my contention that a long overdue appraisal of female characterisation in Hubert de Vere can shed novel light –at once both disturbing and liberating– on Frances Burney’s oeuvre at large.
Exact Matrix Factorization Updates for Nonlinear Programming
Authors: Escobedo Adolfo R. 
Published: September 2023

LU and Cholesky matrix factorization algorithms are core subroutines used to solve systems of linear equations (SLEs) encountered when solving an optimization problem. Standard floating-point algorithms are highly efficient but remain susceptible to the accumulation of round-off errors, which can lead solvers to return feasibility and optimality claims that are actually invalid. This paper introduces a novel direct solution approach for solving sequences of closely related SLEs encountered in nonlinear programming efficiently and without round-off errors. Specifically, it introduces rank-one update algorithms for the round-off error–free factorization framework, a tool set built on integer-preserving arithmetic that has led to the development and implementation of extremely reliable subroutines for solving SLEs occurring in linear programming. The formal guarantees of the presented algorithms are established through the derivation of theoretical insights. Their advantages are supported with computational experiments, which demonstrate upward of 75× improvements over exact factorization runtimes on fully dense matrices with more than one million entries. A significant advantage of the featured integer-preserving framework is that the length of any matrix coefficient produced by its algorithms is bounded polynomially in the size of the inputs without having to resort to greatest common divisor operations, which are required by and thereby hinder an efficient implementation of exact rational arithmetic approaches. History: Accepted by Antonio Frangioni, Area Editor for Design & Analysis of Algorithms–Continuous. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2021.0331 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0331 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Transformações societárias, América Latina e Serviço Social
Authors: Moljo Carina Berta , Da Silva José Fernando Siqueira da Silva Fernando Siqueira , Soto Silvia Fernández 
Published: September 2023

O artigo que ora apresentamos tem como objetivo principal analisar o contexto latino-americano no cenário de crise do capital, marcado pelo recrudescimento de políticas neoliberais, por restrições do Estado social e pela perda de direitos e expansão de práticas punitivas que afetam a classe trabalhadora na sua diversidade. O texto procura debater, sumariamente, a forma como a questão social e suas múltiplas refrações se expressam na atualidade, como são construídas as políticas sociais no contexto de desmanche do Estado, bem como as potencialidades e limites do Serviço Social como profissão nesta complexidade, seu sentido socioeducativo crítico. Palavras-Chave: América Latina; capitalismo; políticas sociais; Serviço Social; trabalho socioeducativo.