bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics and Outcomes of Patients With Cutibacterium acnes Endocarditis
Authors: Heinen Floris J. , Arregle Florent , van den Brink Floris S. , Ajmone Marsan Nina , Bernts Lucas , Houthuizen Patrick , Kamp Otto , Roescher Nienke , Timmermans Naomi , Verkaik Nelianne , Roos-Hesselink Jolien , Post Marco C , Habib Gilbert , Tanis Wilco 
Published: July 2023

ImportanceIt is suggested that patients with Cutibacterium acnes endocarditis often present without fever or abnormal inflammatory markers. However, no study has yet confirmed this statement.ObjectiveTo assess the clinical characteristics and outcomes of patients with C acnes endocarditis.Design, Setting, and ParticipantsA case series of 105 patients presenting to 7 hospitals in the Netherlands and France (4 university hospitals and 3 teaching hospitals) with definite endocarditis according to the modified Duke criteria between January 1, 2010, and December 31, 2020, was performed. Clinical characteristics and outcomes were retrieved from medical records. Cases were identified by blood or valve and prosthesis cultures positive for C acnes, retrieved from the medical microbiology databases. Infected pacemaker or internal cardioverter defibrillator lead cases were excluded. Statistical analysis was performed in November 2022.Main Outcomes and MeasuresMain outcomes included symptoms at presentation, presence of prosthetic valve endocarditis, laboratory test results at presentation, time to positive results of blood cultures, 30-day and 1-year mortality rates, type of treatment (conservative or surgical), and endocarditis relapse rates.ResultsA total of 105 patients (mean [SD] age, 61.1 [13.9] years; 96 men [91.4%]; 93 patients [88.6%] with prosthetic valve endocarditis) were identified and included. Seventy patients (66.7%) did not experience fever prior to hospital admission, nor was it present at hospitalization. The median C-reactive protein level was 3.6 mg/dL (IQR, 1.2-7.5 mg/dL), and the median leukocyte count was 10.0 × 103/µL (IQR, 8.2-12.2 × 103/µL). The median time to positive blood culture results was 7 days (IQR, 6-9 days). Surgery or reoperation was indicated for 88 patients and performed for 80 patients. Not performing the indicated surgical procedure was associated with high mortality rates. Seventeen patients were treated conservatively, in accordance with the European Society of Cardiology guideline; these patients showed relatively high rates of endocarditis recurrence (5 of 17 [29.4%]).Conclusions and RelevanceThis case series suggests that C acnes endocarditis was seen predominantly among male patients with prosthetic heart valves. Diagnosing C acnes endocarditis is difficult due to its atypical presentation, with frequent absence of fever and inflammatory markers. The prolonged time to positivity of blood culture results further delays the diagnostic process. Not performing a surgical procedure when indicated seems to be associated with higher mortality rates. For prosthetic valve endocarditis with small vegetations, there should be a low threshold for surgery because this group seems prone to endocarditis recurrence.
Time Interval Between the End of Neoadjuvant Therapy and Elective Resection of Locally Advanced Rectal Cancer in the CRONOS Study
Authors: Guzmán Yoelimar , Ríos José , Paredes Jesús , Domínguez Paula , Maurel Joan , González-Abós Carolina , Otero-Piñeiro Ana , Almenara Raúl , Ladra María , Prada Borja , Pascual Marta , Guerrero María Alejandra , García-Granero Álvaro , Fernández Laura , Ochogavia-Seguí Aina , Gamundi-Cuesta Margarita , González-Argente Francesc Xavier , Pons Lorenzo Viso , Centeno Ana , Arrayás Ángela , de Miguel Andrea , Gil-Gómez Elena , Gómez Beatriz , Martínez José Gil , Lacy Antonio M. , de Lacy F. Borja 
Published: July 2023

ImportanceThe treatment for extraperitoneal locally advanced rectal cancer (LARC) is neoadjuvant therapy (NAT) followed by total mesorectal excision (TME). Robust evidence on the optimal time interval between NAT completion and surgery is lacking.ObjectiveTo assess the association of time interval between NAT completion and TME with short- and long-term outcomes. It was hypothesized that longer intervals increase the pathologic complete response (pCR) rate without increasing perioperative morbidity.Design, Setting, and ParticipantsThis cohort study included patients with LARC from 6 referral centers who completed NAT and underwent TME between January 2005 and December 2020. The cohort was divided into 3 groups depending on the time interval between NAT completion and surgery: short (≤8 weeks), intermediate (&amp;gt;8 and ≤12 weeks), and long (&amp;gt;12 weeks). The median follow-up duration was 33 months. Data analyses were conducted from May 1, 2021, to May 31, 2022. The inverse probability of treatment weighting method was used to homogenize the analysis groups.ExposureLong-course chemoradiotherapy or short-course radiotherapy with delayed surgery.Main outcome and MeasuresThe primary outcome was pCR. Other histopathologic results, perioperative events, and survival outcomes constituted the secondary outcomes.ResultsAmong the 1506 patients, 908 were male (60.3%), and the median (IQR) age was 68.8 (59.4-76.5) years. The short-, intermediate-, and long-interval groups included 511 patients (33.9%), 797 patients (52.9%), and 198 patients (13.1%), respectively. The overall pCR was 17.2% (259 of 1506 patients; 95% CI, 15.4%-19.2%). When compared with the intermediate-interval group, no association was observed between time intervals and pCR in short-interval (odds ratio [OR], 0.74; 95% CI, 0.55-1.01) and long-interval (OR, 1.07; 95% CI, 0.73-1.61) groups. The long-interval group was significantly associated with lower risk of bad response (tumor regression grade [TRG] 2-3; OR, 0.47; 95% CI, 0.24-0.91), systemic recurrence (hazard ratio, 0.59; 95% CI, 0.36-0.96), higher conversion risk (OR, 3.14; 95% CI, 1.62-6.07), minor postoperative complications (OR, 1.43; 95% CI, 1.04-1.97), and incomplete mesorectum (OR, 1.89; 95% CI, 1.02-3.50) when compared with the intermediate-interval group.Conclusions and RelevanceTime intervals longer than 12 weeks were associated with improved TRG and systemic recurrence but may increase surgical complexity and minor morbidity.
Idioms in Morphology
Authors: Everaert Martin 
Published: July 2023

AbstractWhat makes idiomaticity an intriguing topic? Not so much that idioms are listed, but the question as to whether the mismatch between syntax and semantics they represent is reflected in their morpho‐syntactic flexibility or in their lexical representation. Everyone seems to agree that (phrasal) idioms are listed in a storage place of idiosyncratic information, often called ‘the lexicon’: here syntax and morphology meet. Semantic idiosyncrasy in morphology is all around but generally is not taken as a manifestation of idiomaticity as defined by syntacticians. That is unfortunate because idiomaticity in morphology perhaps illustrates better that idiomaticity is more than non‐compositionality. It is about conventionalization, manifested as collocational restrictions. This entry will demonstrate that from that perspective idiomaticity manifests itself abundantly in morphology and is differently tackled by recent theories such as Construction Morphology and Distributed Morphology.
Application of recurrent neural networks for modeling and control of a quadruple‐tank system
Authors: Rajasekhar N. , Nagappan K. Kumaran , Radhakrishnan T.K. , Samsudeen N. 
Published: July 2023

AbstractThe quadruple tank (QT) system consists of four interacting tanks and can switch between the minimum and non‐minimum phase behavior with changes in the positions of pump valves and is considered a benchmark control problem. In the present study, long‐short term memory (LSTM), a type of recurrent neural networks (RNN) is designed for the benchmark QT system based on the model‐based control framework. Random input–output sequences are generated from the white box model of the QT system to train an LSTM network model. The LSTM network is tuned by adjusting its hyperparameters such as the number of hidden layers, hidden units, and epochs to minimize the prediction error on the test data. The trained model is cross validated both during and after training to avoid overfitting. Once a reasonably reliable model is obtained, another LSTM network is trained for use as a controller. The network architecture is constantly modified till the controller is able to track the test setpoints with minimum error. This procedure is repeated with a gated recurrent unit (GRU) network and the servo and regulatory response of both the network models and controller are evaluated in terms of standard performance measure namely root mean square error (RMSE), integral square error (ISE), and control effort (CE). It is observed that the controller designed based on RNN performs better than a conventional centralized controller.
Oxygen Incorporated MoS2 for Rectification‐Mediated Resistive Switching and Artificial Neural Network
Authors: Xiong Xuya , Wu Fan , Ouyang Yi , Liu Yanming , Wang Zegao , Tian He , Dong Mingdong 
Published: July 2023

AbstractMolybdenum disulfide (MoS2) based memristor presents intriguing chance for the implementation bio‐inspired artificial synapse and neural interactions. However, the electrical properties of intrinsic MoS2 single‐crystal film suffer from inevitable lattice defects or structure vacancies as well as restraining reliable resistive switching mechanism. Here, a fundamental study on tunable p‐type doping in MoS2 film by controllable oxygen passivation is reported. In situ KPFM measurements reveal a near‐linear increase in Fermi‐level energy. The TiN/O‐MoS2 memristor exhibits surprising bipolar switching feature, revealing an interesting transition between rectification‐mediated and conduction‐mediated characteristics by means of controllable surficial oxygen kinetics. The resistive window demonstrates nearly symmetric SET and RESET domain and capability to analog programming conductance. Moreover, based on the MoS2 memristor, the accuracy up to 94% for MINST recognition ensures the implementation of neural network and LTP/LTD behaviors. This as‐prepared memristor is capable of mimicking synaptic feature through regulated resistive mechanics and electrode contact interaction, which can be an up‐and‐coming strategy for bio‐realistic electronics.
Modulation of Electron Structure and Dehydrogenation Kinetics of Nickel Phosphide for Hydrazine‐Assisted Self‐Powered Hydrogen Production in Seawater
Authors: Chi Jingqi , Guo Lili , Mao Jiayu , Cui Tong , Zhu Jiawei , Xia Yanan , Lai Jianping , Wang Lei 
Published: July 2023

AbstractThe electrocatalytic production of hydrogen from seawater provides a low‐cost way to realize energy conversion, but is restricted by high potential for seawater electrolysis and the chlorine oxidation reaction (ClOR) at the anode. Here, the self‐growth of Mo‐doped Ni2P nanosheet arrays with rich P vacancies on molybdenum‐nickel foam (MNF) (Mo‐Ni2Pv@MNF) is reported as bifunctional catalyst for Cl‐free hydrogen production by coupling hydrogen evolution reaction (HER) with hydrazine oxidation reaction (HzOR) in seawater. Impressively, the Mo‐Ni2Pv@MNF electrode as bifunctional catalyst has an excellent activity for overall hydrazine splitting (OHzS) with an ultralow voltage of only 571 mV at 1000 mA cm−2 and can maintain stability for an ultra‐long time of 1000 h at 100 mA cm−2. Moreover, integration of OHzS into self‐assembled hydrazine fuel cells (DHzFC) or solar cells can enable the self‐powered H2 production. The industrial hydrazine sewage as feed for the above eletrolysis system can be degraded to ≈5 ppb rapidly. Density functional thoery calculations demonstrate that the electronic structure modulation induced by P vacancies and Mo doping can not only achieve thermoneutral ΔGH* for hydrogen evolution reaction but also enhance dehydrogenation kinetics from *N2H4 to *NHNH2 for HzOR, achieving enhanced dehydrogenation kinetics.
Template‐Assisted Electrospun Ordered Hierarchical Microhump Arrays‐Based Multifunctional Triboelectric Nanogenerator for Tactile Sensing and Animal Voice‐Emotion Identification
Authors: Cui Meijie , Guo Hao , Zhai Wei , Liu Chuntai , Shen Changyu , Dai Kun 
Published: July 2023

AbstractThe development of flexible and adaptable multifunctional sensing systems for human–machine interaction, especially for animal voice‐emotion identification, is highly desirable yet quite challenging. Herein, a multifunctional triboelectric nanogenerator (TENG) based on ordered hierarchical microhump arrays is proposed and fabricated by template‐assisted electrospinning with a facile, low‐cost, and expandable manufacturing process. Performances of a single‐electrode TENG based on the patterned nanofiber films with microhump arrays (NFM‐TENG) are studied in detail by varying mesh number of the template. Electric field structure of the collector is altered by pore sizes, wire diameters, and protrusions of the receiving templates subjected to different mesh numbers, generating different degrees of microhump arrays on the surface of the nanofiber film. NFM‐TENG demonstrates high sensitivity (15.94 mV Pa−1), fast response and recovery time (76 and 58 ms), a large power density of 122 mW m−2, and excellent ability of structural retention. Integrated with four functions of energy harvesting, pressure sensing, human physiological sensing, and animal voice‐emotion identification, NFM‐TENG achieves real‐time monitoring of human physiological, motion, handwriting, and animal voice‐emotion signals without an external power supply. This study shows significant application strategies for self‐powered human–machine interaction devices, novel animal voice‐emotion identification, biodiversity conservation, and so on.
Synthesis of Planet‐Like Liquid Metal Nanodroplets with Promising Properties for Catalysis
Authors: Parker Caiden J. , Krishnamurthi Vaishnavi , Zuraiqi Karma , Nguyen Chung Kim , Irfan Mehmood , Jabbar Fahad , Yang Dan , Aukarasereenont Mew P. , Mayes Edwin L. H. , Murdoch Billy J. , Elbourne Aaron , Chiang Ken , Daeneke Torben 
Published: July 2023

AbstractLiquid metal nanodroplets are an emerging class of underexplored materials with significant potential in many applications, including catalysis, bio‐therapeutics, and phase‐change materials. These nanostructures are generally synthesized by mechanical agitation via ultrasonication of low‐melting metals like Ga. Once these materials are successfully synthesized, they can be suspended in a vast array of different solvents. However, one major issue arises specifically with liquid metal alloys which are found to de‐alloy in the sonication process. Here, it is demonstrated that this challenge can be overcome by undertaking sonication at high temperatures, suspending nanodroplets within molten sodium acetate (NaOAc). After cooling, the nanostructures become planet‐like nanodroplets which are covered by an interfacial oxide crust, feature a liquid metal mantle, and a solid core. The molten salt solvent can effectively be removed rendering this approach to be ideal, especially for catalysts. The proof‐of‐concept application is demonstrated by carrying out electrocatalytic ethanol oxidation, using the Cu–Ga system. The superior performance of the Cu–Ga nanodroplets highlights potential in catalyzing a vast array of reactions. Aside from the Cu–Ga system, this facile process can be applied to multiple other systems, including Ag–Ga, Zn–Ga, Bi–Ga, In–Cu, and Sn–Cu.
Dual Mode TENG with Self‐Voltage Multiplying Circuit for Blue Energy Harvesting and Water Wave Monitoring
Authors: Shan Chuncai , He Wencong , Wu Huiyuan , Fu Shaoke , Li Kaixian , Liu Anping , Du Yan , Wang Jian , Mu Qianjin , Liu Boyuan , Xi Yi , Hu Chenguo 
Published: July 2023

AbstractAs the most extensive natural energy on earth, ocean wave energy is regarded as a difficult energy to be fully and efficiently utilized because of its low frequency and multi‐direction movement. Herein, a versatile blue energy triboelectric nanogenerator (VBE‐TENG) fabricated by using dual‐mode output terminals with charge excitation strategy is reported, which can harvest varying water‐wave energy effectively. Benefiting from the rolling ball on a specific track and the compression rebound characteristics of a spring sheet steel, the carrier can be driven along a specific path through random ocean wave energy, and then the energy is converted into electricity by VBE‐TENG. A high peak output power of 34.3 mW is obtained, 2.5 times as much as that of current highest record based on a device unit in blue energy TENG. In addition, the TENG can light 256 LEDs and continuously power commercial electronic devices in wave environments. The average peak voltage of contact‐separation TENG is converted into virtual signal via Labview software to provide wave height monitoring as a self‐powered sensing system. This work provides a new approach in blue energy TENG toward practical applications.
Integrating Energy Band Alignment and Oxygen Vacancies Engineering of TiO2 Anatase/Rutile Homojunction for Kinetics‐Enhanced Li–S Batteries
Authors: Ma Li , Zhang Youquan , Zhang Shuai , Wang Li , Zhang Chunxiao , Chen Yuejiao , Wu Qing , Chen Libao , Zhou Liangjun , Wei Weifeng 
Published: July 2023

AbstractThe inferior shuttle effect of intermediate lithium polysulfides and the sluggish kinetics of sulfur redox reaction are two serious puzzles for the application of lithium–sulfur batteries. Herein, energy band alignment is combined with oxygen vacancies engineering to obtain TiO2 anatase/rutile homojunction (A/R‐TiO2) with effective immobilization and high‐efficiency catalytic conversion of polysulfides. Theoretical calculations and experiments reveal that the near perfect energy band alignment in A/R‐TiO2 is conducive to fluent charge transfer and high catalytic activity, while the rich oxygen vacancies are engineered to provide abundant active sites for anchoring and accelerating conversion of soluble polysulfides. As a result, a battery with A/R‐TiO2‐modified separator delivers a marked sulfur utilization (1210 mAh g−1 at 0.1 C and 689 mAh g−1 at 1 C, 3.75 mg cm−2) and a high capacity retention of 63% over 300 cycles at 0.5 C (3.25 mg cm−2). More importantly, the A/R‐TiO2‐modified separator endows the pouch cell with a high capacity of 128.5 mAh at 0.05 C with a lean electrolyte/sulfur ratio for practical application (S loading: 4 mg cm−2).
Intrinsically Stretchable and Efficient Fully Π‐Conjugated Polymer via Internal Plasticization for Flexible Deep‐Blue Polymer Light‐Emitting Diodes with CIEy = 0.08
Authors: Zhuo Zhiqiang , Ni Mingjian , An Xiang , Bai Lubing , Liang Xinyu , Yang Jing , Zheng Yingying , Liu Bin , Sun Ning , Sun Lili , Wei Chuanxin , Yu Ningning , Chen Wenyu , Li Mengyuan , Xu Man , Lin Jinyi , Huang Wei 
Published: July 2023

AbstractIntrinsically stretchable polymeric semiconductors are essential to flexible polymer light‐emitting diodes (PLEDs) owing to their excellent strain tolerance capacity under long‐time deformation operation. Obtaining intrinsic stretchability, robust emission properties, and excellent charge‐transport behavior simultaneously from fully π‐conjugated polymers (FCPs) is difficult, particularly for applications in deep‐blue PLEDs. Herein, an internal plasticization strategy is proposed to introduce a phenyl‐ester plasticizer into polyfluorenes (PF‐MC4, PF‐MC6, and PF‐MC8) for narrowband deep‐blue flexible PLEDs. Compared with controlled poly[4‐(octyloxy)‐9,9‐diphenylfluoren‐2,7‐diyl]‐co‐[5‐(octyloxy)‐9,9‐diphenylfluoren‐2,7‐diyl] (PODPFs) (2.5%), the freestanding PF‐MC8 thin film shows a fracture strain of >25%. The three stretchable films exhibit stable and efficient deep‐blue emission (PLQY > 50%) because of the encapsulation of π‐conjugated backbone via pendant phenyl‐ester plasticizers. The PF‐MC8‐based PLEDs show deep‐blue emission, which corresponds to CIE and EQE values of (0.16, 0.10) and 1.06%, respectively. Finally, the narrowband deep‐blue electroluminescence (FWHM of ≈25 nm; CIE coordinates: (0.15, 0.08)) and performance of the transferred PLEDs based on the PF‐MC8 stretchable film are independent of the tensile ratio (up to 45%); however, they show a maximum brightness of 1976 cd m−2 at a ratio of 35%. Therefore, internal plasticization is a promising approach for designing intrinsically stretchable FCPs for flexible electronics.
Engineering Efficient CAR‐T Cells via Electroactive Nanoinjection
Authors: Shokouhi Ali‐Reza , Chen Yaping , Yoh Hao Zhe , Brenker Jason , Alan Tuncay , Murayama Takahide , Suu Koukou , Morikawa Yasuhiro , Voelcker Nicolas H. , Elnathan Roey 
Published: July 2023

AbstractChimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based immunotherapy approach for treating blood disorders and cancers, but genetically engineering CAR‐T cells is challenging due to primary T cells’ sensitivity to conventional gene delivery approaches. The current viral‐based method can typically involve significant operating costs and biosafety hurdles, while bulk electroporation (BEP) can lead to poor cell viability and functionality. Here, a non‐viral electroactive nanoinjection (ENI) platform is developed to efficiently negotiate the plasma membrane of primary human T cells via vertically configured electroactive nanotubes, enabling efficient delivery (68.7%) and expression (43.3%) of CAR genes in the T cells, with minimal cellular perturbation (>90% cell viability). Compared to conventional BEP, the ENI platform achieves an almost threefold higher CAR transfection efficiency, indicated by the significantly higher reporter GFP expression (43.3% compared to 16.3%). By co‐culturing with target lymphoma Raji cells, the ENI‐transfected CAR‐T cells’ ability to effectively suppress lymphoma cell growth (86.9% cytotoxicity) is proved. Taken together, the results demonstrate the platform's remarkable capacity to generate functional and effective anti‐lymphoma CAR‐T cells. Given the growing potential of cell‐based immunotherapies, such a platform holds great promise for ex vivo cell engineering, especially in CAR‐T cell therapy.
Harnessing Supported Gold Nanoparticle as a Single‐Electron Transfer Catalyst for Decarboxylative Cross‐Coupling
Authors: Miura Hiroki , Ameyama Kaede , Shishido Tetsuya 
Published: July 2023

AbstractWe found that gold nanoparticles function as single‐electron transfer catalysts to promote decarboxylative cross‐coupling between N‐hydroxy phthalimide esters and disilanes or diborons. A variety of disilanes coupled with alkyl radicals could be generated from N‐hydroxy phthalimide esters via single‐electron reduction by active carbon‐supported gold nanoparticle catalysts to afford diverse alkylsilanes without the need for external bases. Furthermore, the present gold catalytic system was also effective for decarboxylative carbon‐boron coupling to afford alkyl boronates. A detailed mechanistic investigation revealed that single‐electron transfer mediated by supported gold nanoparticles enabled the generation of alkyl radical and silyl radical, thereby enabling radical cross‐coupling. The reusability and environmentally‐friendly nature of supported gold catalyst as well as the scalability of the reaction system enable the practical transformation of carboxylic acid derivatives into value‐added organosilicon and organoboron compounds.