bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of reduction of paediatric forearm fracture by emergency department clinicians
Authors: Gursanscky Jared , Kelly Anne‐Maree , Hamad Ahmad , Tagg Andrew , Klim Sharon , Ritchie Peter , Law Ian , Krieser David 
Published: January 2023

AbstractObjectivesPaediatric forearm fractures are common. Anecdotally, there is a trend towards ED reduction of selected fractures under procedural sedation. We aimed to determine the rate of subsequent operative intervention for fracture re‐displacement.MethodsRetrospective observational study of children with a forearm/wrist fracture undergoing fracture reduction in ED. Outcome of interest was operative intervention for fracture re‐displacement within 6 weeks.ResultsAmong 176 patients studied, operative intervention occurred in nine patients (5.1%, 95% confidence interval 2.7–9.4%).ConclusionReduction of paediatric forearm fractures under procedural sedation by ED clinicians is increasingly common and results in a low rate of subsequent operative intervention.
The Aphelenchoides genomes reveal substantial horizontal gene transfers in the last common ancestor of free‐living and major plant‐parasitic nematodes
Authors: Lai Cheng‐Kuo , Lee Yi‐Chien , Ke Huei‐Mien , Lu Min R. , Liu Wei‐An , Lee Hsin‐Han , Liu Yu‐Ching , Yoshiga Toyoshi , Kikuchi Taisei , Chen Peichen J. , Tsai Isheng Jason 
Published: January 2023

AbstractAphelenchoides besseyi is a plant‐parasitic nematode (PPN) in the family Aphelenchoididae capable of infecting more than 200 plant species. A. besseyi is also a species complex with strains exhibiting varying pathogenicity to plants. We present the genome and annotations of six Aphelenchoides species, four of which belonged to the A. besseyi species complex. Most Aphelenchoides genomes have a size of 44.7–47.4 Mb and are among the smallest in clade IV, with the exception of A. fujianensis, which has a size of 143.8 Mb and is one of the largest. Phylogenomic analysis successfully delimited the species complex into A. oryzae and A. pseudobesseyi and revealed a reduction of transposon elements in the last common ancestor of Aphelenchoides. Synteny analyses between reference genomes indicated that three chromosomes in A. besseyi were derived from fission and fusion events. A systematic identification of horizontal gene transfer (HGT) genes across 27 representative nematodes allowed us to identify two major episodes of acquisition corresponding to the last common ancestor of clade IV or major PPNs, respectively. These genes were mostly lost and differentially retained between clades or strains. Most HGT events were acquired from bacteria, followed by fungi, and also from plants; plant HGT was especially prevalent in Bursaphelenchus mucronatus. Our results comprehensively improve the understanding of HGT in nematodes.
Paleozoic Tectonic Switch in the North Qinling Orogenic Belt: Constraints from the Paleozoic Granites from the Northern Qinling Migmatite Terrane
Authors: QIN Jiangfeng , LAI Shaocong , LONG Xiaoping 
Published: January 2023

AbstractThe variations in source rocks and melting conditions of granites can provide essential clues for the crustal magmatic response in orogenic process. Based on geochronology, whole‐rock and mineral chemistry, this paper reveals two different granites in the Northern Qinling migmatite complex, which reveal obvious differences in source region and melting condition. The older granodiorite (402 ± 0.8 Ma) displays typical Na‐rich adakite affinity, i.e., high Na2O/K2O (2.04 to 2.64) and Sr/Y (96 to 117) ratios, they have relative evolved isotopic compositions (εNd(t) = –0.52 to –0.04; zircon εHf(t) = –0.06 to +7.78). The younger leucogranite (371 ± 2 Ma) displays higher SiO2 (72.32 to 73.45 wt%), lower (TFeO + MgO + CaO + TiO2) contents (<2 wt%) and depleted Sr‐Nd‐Hf isotopic compositions (i.e., εNd(t) = +2.6 to +3.0; zircon εHf(t) = +5.94 to +14.12), as well as high 10000 × Ga/Al and TFeO/MgO ratios, indicating that they represent highly fractionated I‐type granites that derived from melting of juvenile crust. The variations in source rocks and melting condition of the two granites indicating a tectonic switch from compression to extension in 400 to 370 Ma, this switch is later than that in the eastern section of the North Qinling, indicating a scissor collision process between the South Qinling and North China Craton (NCC) in Devonian era.
Salt‐Lake Basin Bedrock Weathered Crust Gas Reservoir in the Altun Mountains Front of the Qaidam Basin, Western China
Authors: ZHANG Yongshu , JIA Chengzao , LI Guoxin , LI Jiangtao , WANG Bo , ZHAO Fan , YUE Dali , SHI Zhenghao , ZHU Jun , WANG Yuanfei , ZHANG Yi , CHEN Yangyang , ZHANG Fenying , YU Xue , XU Li , Hou Lili , SONG Yue 
Published: January 2023

AbstractThe bedrock weathered crust in front of the Altun Mountains in the Qaidam Basin, western China, is different from others because this is a salt‐lake basin, where saline water fluid infiltrates and is deposited in the overlying strata. A large amount of gypsum infills the bedrock weathered crust, and this has changed the pore structure. Using core observation, polarized light microscopy, electron probe, physical property analysis and field emission scanning electron microscopy experiments, the characteristics of the weathered bedrock have been studied. There are cracks and a small number of dissolved pores in the interior of the weathered crust. Matrix micropores are widely developed, especially the various matrix cracks formed by tectonics and weathering, as well as the stress characteristics of small dissolved pores, and physical properties such as porosity and permeability. This ‘dual structure’ developed in the bedrock is important for guiding the exploration of the lake basin bedrock for natural gas.
Competing endogenous RNA network construction based on long non‐coding RNAs, microRNAs, and mRNAs related to fat deposition in Songliao black swine
Authors: Liu Yibing , Xing Kai , Ao Hong , Zhang Fengxia , Zhao Xitong , Liu Huatao , Shi Yong , Yu Ying , Wang Chuduan 
Published: January 2023

AbstractChina has a long history of pig breeding and a number of local breeds. The Songliao Black pig, bred in China in 2009, shows high variation in backfat thickness and therefore is well‐suited to fat deposition research. Fat deposition is a complex trait, and the underlying regulatory factors are not fully characterized. In this study, the molecular basis of fat deposition traits was evaluated by comparisons between three individuals with extremely high‐backfat thickness and three with extremely low‐backfat thickness selected from 53 gilts. Subcutaneous adipose tissues of the back were collected for strand‐specific library RNA sequencing (RNA‐seq) and small RNA‐seq. We identified 13 184 mRNAs, 2046 long non‐coding (lnc)RNAs, and 494 micro (mi)RNAs by high‐throughput sequencing. Furthermore, we detected 150 differentially expressed mRNAs, 66 differentially expressed lncRNAs, and eight differentially expressed miRNAs. A functional enrichment analysis indicated that these genes are involved in multiple fat metabolism‐related pathways, including positive regulation of fat cell differentiation, and fat digestion and absorption. We used various algorithms (miRanda, TargetScan, and RNAhybrid) to predict targeting relationships and constructed a competing endogenous RNA network containing seven lncRNAs, three miRNAs, and six mRNAs. All these genes were differentially expressed between the extremely high and low backfat thickness groups or enriched in pathways related to fat metabolism. Our results provide insight into the regulatory mechanisms by which non‐coding RNAs and their target genes influence backfat deposition in pigs. Furthermore, our newly constructed competing endogenous RNA (lncRNA‐miRNA‐mRNA) network provides a basis for further exploration of fat deposition traits and non‐coding RNA functions.
Does Information Disclosed in “Use of Proceeds” from Prospectuses Affect IPO Initial Underpricing?
Authors: Tang Wenxiu , Zhou Zhong‐Guo 
Published: January 2023

AbstractWe study the impact of intended use of proceeds disclosed in the section of “Use of Proceeds” in prospectuses on ChiNext IPOs' initial underpricing. After splitting the entire period into two non‐overlapping sub‐periods to control for regulatory changes and after controlling for the firm‐level characteristics and market conditions, we find that the overall information disclosed from “Use of Proceeds” affects IPO initial underpricing significantly over the two sub‐periods. Moreover, the intended use of IPO proceeds in several specific categories affects underpricing too. The proceeds raised for IPO firms' information platform and research and development over the second sub‐period while the proceeds to promote marketing and sales and to expand existing products over the first sub‐period are significantly and positively related to initial underpricing. The significance changes for the IPOs with the opportunity to change their use of proceeds after IPOs. We explore the causes and effects to explain our findings.
Autologous Th2‐polarized lymphocytes induce atopic dermatitis lesions in non‐atopic human skin xenotransplants
Authors: Keren Aviad , Reich Kristian , Bertolini Marta , Moga Alain , Riethmüller Christoph , Ullmann Yehuda , Paus Ralf , Gilhar Amos 
Published: January 2023

AbstractBackgroundThe key signals that suffice to induce atopic dermatitis (AD) in human skin remain incompletely understood. Also, current mouse models reflect human AD only unsatisfactorily. Therefore, we have asked whether a humanized AD mouse model can be developed that reflects human AD more faithfully and permit to identify key signals that suffice to induce AD lesions in previously healthy human skin in vivo.MethodsHealthy human skin from non‐atopic donors was transplanted onto SCID/beige mice. After xenotransplant reinnervation by mouse sensory nerve fibers had occurred, mixed autologous human Th2 CD4+ and Tc2 CD8+ T cells that had been pretreated in vitro with IL‐2, IL‐4, and LPS were injected intradermally into the xenotransplants without skin barrier disruption.ResultsInjected non‐atopic xenotransplants rapidly developed a morphological, functional, and immunological phenocopy of human AD lesions regarding skin barrier defects, immunopathology including intraepidermal eosinophils, mast cell activation, increase of thymic stromal lymphopoietin, eotaxin‐1 and type 2 cytokine circuits, and even showed characteristic neuroimmunological abnormalities such as ß2‐adrenergic receptor downregulation. The experimentally induced AD lesions in human skin responded to standard AD therapy (topical dexamethasone or tacrolimus; systemic anti‐IL‐4Rα antibody [dupilumab]), and relapsed when neurogenic skin inflammation was induced by exposing mice to perceived stress.ConclusionsThis new animal model uniquely mimics the complexity of human AD and its clinical response to standard therapy and psychoemotional stressors in vivo, and shows that Th2‐polarized lymphocytes associated with excessive IL‐4Rα‐mediated signaling suffice to induce human AD skin lesions, while atopy and epidermal barrier disruption are dispensable.
Electrocardiographic changes in acute myocardial infarction with acute occlusion of all triple coronary arteries
Authors: Jin Dongxia , Hu Yuecheng , Cong Hongliang 
Published: January 2023

AbstractThe 66‐year‐old woman was diagnosed with “acute myocardial infarction” due to acute triple vessel occlusion based on clinical symptoms, laboratory examination, and coronary angiography (CAG), but her ECG showed ST‐segment depression in leads aVR and aVL, in addition to ST‐segment elevation in a wide range of leads (V1–V9, V3R–V5R, II, III, and aVF). Thus, a perfect explanation with the existing theory is difficult, and only the case is presented here.
The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non‐anesthetized sheep
Authors: Jufar Alemayehu H. , Evans Roger G. , May Clive N. , Hood Sally G. , Betrie Ashenafi H. , Trask‐Marino Anton , Bellomo Rinaldo , Lankadeva Yugeesh R. 
Published: January 2023

AbstractAimRecruitment of renal functional reserve (RFR) with amino acid loading increases renal blood flow and glomerular filtration rate. However, its effects on renal cortical and medullary oxygenation have not been determined. Accordingly, we tested the effects of recruitment of RFR on renal cortical and medullary oxygenation in non‐anesthetized sheep.MethodsUnder general anesthesia, we instrumented 10 sheep to enable subsequent continuous measurements of systemic and renal hemodynamics, renal oxygen delivery and consumption, and cortical and medullary tissue oxygen tension (PO2). We then measured the effects of recruitment of RFR with an intravenous infusion of 500 ml of a clinically used amino acid solution (10% Synthamin® 17) in the non‐anesthetized state.ResultsCompared with baseline, Synthamin® 17 infusion significantly increased renal oxygen delivery mean ± SD maximum increase: (from 0.79 ± 0.17 to 1.06 ± 0.16 ml/kg/min, p < 0.001), renal oxygen consumption (from 0.08 ± 0.01 to 0.15 ± 0.02 ml/kg/min, p < 0.001), and glomerular filtration rate (+45.2 ± 2.7%, p < 0.001). Renal cortical tissue PO2 increased by a maximum of 26.4 ± 1.1% (p = 0.001) and medullary tissue PO2 increased by a maximum of 23.9 ± 2.8% (p = 0. 001).ConclusionsIn non‐anesthetized healthy sheep, recruitment of RFR improved renal cortical and medullary oxygenation. These observations might have implications for the use of recruitment of RFR for diagnostic and therapeutic purposes.
Prevalence of depression and anxiety, and associated factors, among Chinese primary and high school students: A cross‐sectional, epidemiological study
Authors: Yu Yanjie , Liu Jiaxiu , Skokauskas Norbert , Liu Feng , Zhang Li , Teng Teng , Zou Yaru , Lyu Qian , Liu Rong , Liu Xinyue , Meng Huaqing , Zhou Xinyu 
Published: January 2023

AbstractIntroductionThis study aimed to investigate the prevalence of depression and anxiety, and associated factors, among Chinese children and adolescents aged 8–18 years who attend primary or high school.MethodsA total of 23 005 primary and high school students were recruited from February to December, 2019 for this cross‐sectional study. The questionnaire included demographic information, questions assessing suicidality, resilience, depression (Center for Epidemiological Studies Depression Scale for Children), and anxiety (Screen for Child Anxiety Related Disorders). Binary logistic regression was used to analyze the independent correlates of depression and anxiety.ResultsOverall, 13.06% of participants experienced depressive symptoms, 22.34% experienced anxiety symptoms, 26.34% experienced transient suicidal ideation, 2.23% had serious suicidal ideation, and 1.46% had a history of suicide attempts. Anxiety (odds ratio [OR], 4.935; 95% confidence interval [CI][4.442–5.485]), suicidality (OR, 2.671; 95% CI[2.203–3.237]), skipping breakfast (OR, 1.920; 95% CI[1.348–2.736]), sleep duration (OR, 0.470; 95% CI[0.398–0.556]) and self‐expectations (OR, 1.924; 95% CI[1.550–2.389]) were associated with depression (all p < .05). Depression (OR, 4.424; 95% CI[3.983–4.914]), female sex (OR, 1.903; 95% CI[1.759–2.060]), school‐based traumatic experience(s) (OR, 1.905; 95% CI[1.747–2.077]), relationships with teachers (OR, 1.575; 95% CI[1.103–2.249]), and suicidality (OR, 1.467; 95% CI[1.218–1.766]) were associated with anxiety symptoms (all p < .05).DiscussionDepression and anxiety are common among school‐age children and adolescents in China. Childhood school‐ and family‐based traumatic experience(s), female sex, and lifestyle factors (eating breakfast, sleep duration, exercising, and Internet use) are significantly associated with mental health among children and adolescents. Developing interventions targeting these factors to protect students from depression and anxiety are needed.
The reflection of desire for revenge and revenge fantasies in drawings and narratives of sexually abused children
Authors: Lev‐Wiesel Rachel , Leibovich Inbal , Doron Hadas , Maman Tslil , Cohen Batya , Moskowitz Nehemia , Saady Ibtisam , Klein Limor , Binson Bussakorn 
Published: January 2023

AbstractWhereas the desire for revenge for an unjust deed is considered natural, its use within the therapeutic setting is scarce, specifically in sexually victimized children. The study aimed to find how experiencing sexual molestation during childhood and the revenge fantasy is reflected in drawings and narratives of sexually victimized children. Following ethical approval and signing a consent form, 14 children who experienced sexual abuse and were psychologically treated (ages 11–18) were recruited. They were asked to draw two drawings: “draw an unjust event that had happened to you” and “draw what you would have liked to happen to the person that unjustly treated you.” At completion, participants were asked to give a narrative to each drawing. Phenomenological analysis of the drawings and narratives indicated that most participants refrained from using more than two colours, did not draw the perpetrator and drew schematic figures. The main themes that emerged in the drawings and the narratives were feeling of loneliness, aloneness, and the desire for role reversal.
Molecular basis of carotid body tumor and associated clinical features in Japan identified by genomic, immunohistochemical, and clinical analyses
Authors: Yoshihama Keisuke , Mutai Hideki , Sekimizu Mariko , Ito Fumihiro , Saito Shin , Nakamura Shintaro , Mikoshiba Takuya , Nagai Ryoto , Takebayashi Akiko , Miya Fuyuki , Kosaki Kenjiro , Ozawa Hiroyuki , Matsunaga Tatsuo 
Published: January 2023

AbstractCarotid body tumor (CBT) is classified as a paraganglioma (PGL). Here, we report the genetic background, protein expression pattern, and clinical findings of 30 Japanese CBT cases. Germline pathogenic or likely pathogenic (P/LP) variants of genes encoding succinate dehydrogenase subunits (SDHs) were detected in 15 of 30 cases (50%). The SDHB variants were the most frequently detected, followed by SDHA and SDHD variants. One case with SDHAF2 variant was bilateral CBT, and other two multiple PGL cases were not detected P/LP variants. The three cases with germline variants that could be tested did not have somatic P/LP variants of the same genes. Immunohistochemical analysis showed negative SDHB signals in CBT tissues in five cases with germline P/LP variants of SDHB, SDHD, or SDHA. In addition, SDHB signals in CBT tissues were negative in four of nine cases without germline P/LP variants of SDHs. These findings suggest the involvement of unidentified molecular mechanisms affecting SDHs.
Women's political agency in difficult settings: Analysis of evidence from Egypt, Nigeria, Mozambique, and Pakistan
Authors: Nazneen Sohela 
Published: January 2023

SummaryMotivationMale gatekeeping and biased social norms in difficult settings characterized by fragility, authoritarianism, and conflict create challenges for women's political participation. This article explores the nature of challenges experienced by women and how they exercise political agency in such settings—as voters, claimants, and brokers of services, and as activists.PurposeI investigate the range of expressions of women's political agency and responses they secure from public authorities in difficult settings. I ask the question: how and to what effect do women exercise political agency in difficult settings? Analysis of the range of expressions of political agency allows a broader view of women's engagement in politics.Methods and approachThe article develops a framework to identify the range of expressions of women's individual and collective agency from Action for Empowerment and Accountability (A4EA) studies conducted in Egypt, Mozambique, Nigeria, and Pakistan. This synthesis explores social norms and male gatekeeping; strategies women use to navigate these and limit backlash; and the changes that result from women taking action.FindingsEvidence shows that social norms and male gatekeeping limit women's engagement in politics and their relations with multiple public authorities that operate in difficult settings. Women use gender‐specific repertoires to organize protests and make claims on authorities and specific strategies to reduce the risk of backlash from their own communities and security agencies. The findings show that, while there is some success in claim‐making on specific issues and that at a personal level women feel more empowered, these do not necessarily lead to systemic change.Policy implicationsDonors and local authorities need to develop interventions that tackle male gatekeeping within political parties and communities to facilitate women's political engagement. Flexibility in funding will enable donors to work directly or indirectly with grassroots and national women's rights groups in difficult settings for developing contextualized, bottom‐up interventions. Strengthening pro‐gender‐equality alliances and spaces for deliberation will help to ensure that gender equality is not co‐opted by authoritarian leaders and populist groups and will sustain counter‐narratives.
The “airgap” and “swirling bubbles” signs in a patient with esophageal carcinoma
Authors: Pinto Tiago Castro , Martins Tiago , Seabra Daniel , Moreno Nuno 
Published: January 2023

AbstractIntroductionPneumopericardium is a dreaded complication in esophageal carcinoma.Case descriptionWe report a case of a 62 year old patient with past history of esophageal cancer with pneumopericardium, without hemodynamic compromise. Admission echocardiogram that revealed a pneumopericadium with the presence of the “swirling bubbles” and the “air gap” sign. A small esophagopericardial fistula was postulated as the cause of the pneumopericardium. He underwent esophageal stent placement with almost complete resolution of the pneumopericardium.DiscussionPneumopericardium is usually a sign of marked clinical deterioration in neoplasia and leads to patients’ death few weeks. Here we presented a case, in which a more fortunate and unusual outcome happened.Case descriptionWe present a case of a 62 year old patient, with a past history of esophageal cancer with pulmonary metastases undergoing palliative chemotherapy treatment and with two palliative esophageal stents. Other past medical history included active hepatitis B, arterial hypertension and dyslipidaemia. He was an ex smoker of 80 pack‐year units.
Giant left ventricular inferior wall aneurysm as a late complication after myocardial infarction: A case report
Authors: Hrycek Eugeniusz , Walawska‐Hrycek Anna , Szymański Radosław , Stoliński Jarosław , Nowakowski Przemysław , Żurakowski Aleksander 
Published: January 2023

AbstractA case of a 64‐year‐old patient who was referred to interventional cardiology unit in order to qualify her to mitral valve repair is presented. Transthoracic echocardiography revealed a giant inferior wall basal aneurysm of the left ventricle (44 mm × 31 mm, 57 ml) and coronary angiography revealed chronic total occlusion of the proximal right coronary artery. The patient refused surgical treatment and was treated with pharmacotherapy alone. At 1 year follow‐up, clear progression of the disease was observed. Based on this case study, we would cautiously suggest that in similar cases of large inferobasal wall aneurysms causing severe MR, OMT may be insufficient to prevent disease progression, and that early surgical intervention may be preferred.