bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the curative effect of vertebroplasty with spiral and traditional pushrod injector in the treatment of osteoporotic vertebral fractures
Authors: Xiao Ya-Ping , Liu Yong-Qing , Bei Ming-Jian , Chang Jian-Zhong , Li Zhang-Hua 
Published: February 2023

Abstract
Background
Cement diffusion and cement leakage are key and contradictory problems in the vertebroplasty, so vertebroplasty instruments constantly develop to explore the optimal treatment. The purpose of this study was to evaluate and compare the clinical efficacy of percutaneous vertebroplasty (PVP) with spiral bone cement injector and traditional push-rod injector in the treatment of osteoporotic vertebral compression fractures (OVCF).
Methods
A retrospective study was conducted on 86 patients with OVCF who respectively received PVP surgeries with spiral injector (Observation group) and traditional pushrod injector (Control group) from February 2017 to February 2019. The preoperative baseline data, postoperative clinical efficacy, complications and imaging data between the two groups were analyzed.
Results
Follow-up period was two years. The baseline data of the two groups were comparable (all P > 0.05).The anterior edge height and kyphosis angle of the injured vertebrae were significantly improved in both groups after surgery (all P < 0.05). The VAS and ODI in both groups were significantly lower on 3rd day and 2nd year after surgery than those before surgery, and decreased gradually with time (all P < 0.05). The number of fluoroscopy and operation time in the observation group were significantly lower than those in the control group (all P < 0.05). The kyphosis angle and the recovery rates of kyphosis angle, anterior edge height, and posterior edge height in the observation group were significantly improved compared with the control group (all P < 0.05). The rate of bone cement leakage and the diffusion coefficient of bone cement in the observation group were significantly higher than those of the control group (all P < 0.05). The VAS and ODI in the observation group were significantly lower than those in the control group at 3rd day after surgery (P < 0.05), but there was no statistical difference between the two groups at 2nd year after surgery (P > 0.05).
Conclusions
PVP surgery both with spiral injector and traditional pushrod injector can achieve satisfactory outcomes, which could effectively relieve pain of lower back, improve motor function, obviously restore vertebral height and correct kyphosis. However, the spiral injector can remarkably reduce the number of fluoroscopy, operation time, and the radiation exposure dose of patients and operators. In addition, spiral injector is better than pushrod injector in restoring vertebral height, correcting kyphosis, alleviating pain immediately and improving function. But its rate of bone cement leakage is significantly higher than that of traditional pushrod injector, which requires the surgeons to pay close attention to.
Intelligent Simulation and Optimization of Axial Flow Fan Based on CFD
Authors: zhang shengli , sun yupei , he long , wang changhao 
Published: February 2023

Abstract
Based on the CFD simulation of the axial flow fan for air conditioning, a flexible and fast deformation model of axial flow fan is established in this paper. The influence of different fan design parameters on the performance of axial flow fan under different working conditions, such as different speed, air volume and pressure, is studied. A set of intelligent optimization platform for axial flow fan is formed and the performance of a certain type of fan is optimized under the working condition of 22000m3/h flow rate.
Intrahippocampal effects of Aluminum injection on affective and cognitive response in male Wistar rat: Potential role of oxidative stress
Authors: Zghari Oussama , Azirar Sofia , Lamtai Mouloud , Hessni Aboubaker El , Ouichou Ali , Mesfioui Abdelhalem 
Published: February 2023

Abstract
Aluminum (Al) is one of the more widespread metals in the environment used in various fields and the most abundant known for its neurotoxicity in both humans and animals and could be a potential factor inducing behavioral changes, oxidative stress (OS) and loss of synapses and neurons in the hippocampal and cerebral cortical areas. The main objective of this study is to determine the short-term impact of a single 2 μl intracerebral injection of AlCl3 at different doses on the right hippocampus on affective and cognitive behaviour, on levels of oxidative stress and morphological changes in male Wistar rats. Rats were treated with a single intrahippocampal injection of 2 μL of NaCl (0.9%) (Control) or successively with 2 μL of AlCl3 at 0.5 mg/Kg (Al-0.5), 1 mg/Kg (Al-1) and 2 mg/Kg (Al-2). Five days following surgical procedures, neurobehavioral tests were performed for all groups (OFT, EPM, FST, Y-maze and MWM) and the brain were taken to isolate the hippocampus from adjacent tissues to prepare homogenates for the determination of oxidative stress markers and to examine the morphological change in CA3 hippocampal area. The results clearly demonstrate that Al induced anxiety and depressive-like behaviours, cognitive deficit, increased lipid peroxidation (LPO), nitric oxide (NO) levels, decreased superoxide dismutase (SOD) activity in the hippocampus and mediates progressive alterations characterized by disorganization in the pyramidal cellular arrangement and a decrease in neuronal density in the CA3 hippocampal area. In conclusion, a single intrahippocampal injection of Al induced anxiety-like, depression-like, memory impairment, OS and morphological alterations in the hippocampus.
Whether cytidine deaminase of Mycoplasma hyorhinis promotes drug resistance by decomposing gefitinib
Authors: zhang jie , hu weiguo , song qibin 
Published: February 2023

Abstract
Objective: To investigate whether cytidine deaminase (CDD) of Mycoplasma hyorhinis induces gefitinib resistance in epidermal growth factor receptor (EGFR)-mutated lung cancer cells by decomposing gefitinib.
Method: Download the gene sequence of CDD from NCBI (Gene ID: 61335421) and redesign the CDD sequence. The prokaryotic expression vector and eukaryotic expression vector of CDD were constructed respectively. The H1650 cell line with stable expression of CDD(H1650-CDD) was obtained by lentiviral infection and verified by western blotting. The toxicity of gefitinib to different cells was detected by CCK8 assay. The prokaryotic expression vector was transformed into escherichia coli, through protein induction and protein purification, CDD protein was obtained. High performance liquid chromatography (HPLC) was used to detect whether the CDD can decompose gefitinib.
Results: The prokaryotic expression vector and the eukaryotic expression vector were successfully constructed by molecular cloning, and the H1650-CDD cell line was obtained by lentiviral infection. The cytotoxicity of gefitinib on H1650-CDD cells and H1650wt cells was detected by CCK8 assay. The cell viability of H1650-CDD cells show significant differences with H1650wt in 30 (t=4.223, P= 0.0134), 40 (t=15.05, P=0.0001), 50 (t=2.919, P= 0.0433), 60 (t=12.28, P= 0.0003), 70 (t=22.97, P<0.0001), 80 (t=6.648, P= 0.0027) μmol/L gefitinib; HPLC suggests that there was no difference among the control group, the CDD group and the gefitinib group.
Conclusion: H1650-CDD cells were resistant to gefitinib, but CDD protein can’t decompose gefitinib. Since the common mechanism of gefitinib resistance includes changes in EGFR downstream signals, it is speculated that the mechanism of CDD promoting drug resistance in H1650-CDD cells may be related to cell signaling pathway, which requires further study.
Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma
Authors: Nuthakki Mira , Utti Vivian , McCalla Serena 
Published: February 2023

Abstract
Purpose
Pancreatitis is one of the most important risk factors for pancreatic ductal adenocarcinoma (PDAC). PDAC is a silent, aggressive malignancy that has less than 5% survival rate at 5 years. Detection at early stage and resection of PDAC significantly improves survival. A differentially expressed microRNA panel was sought that could predict the risk of progression to PDAC from pancreatitis.
Methods
Differentially expressed microRNA (DEM) in serum that were common between pancreatitis and PDAC were extracted from two microarray GSE datasets containing pancreatitis, PDAC, and control samples. Eight groups of DEM were derived from multiple bioinformatics methods such as differential expression, miRNA interaction networks, target gene prediction tools, functional enrichment analysis, and machine learning models. The functional enrichment pathway of these groups were identified.

Results

These groups were trained on the original datasets and were used to predict pancreatic cancer in a validation set consisting of six other GSE datasets containing pancreatic cancer and controls. The miRNA panel with the highest precision and recall was the group derived from the target hub genes with the highest interaction (hsa-miR-28-3p, 320b, 320c, 320d, 532-5p, and 423-5p, with a mean F1 of 0.968, mean recall of 0.99, mean precision of 0.947, and mean AUC of 0.995).

Conclusion

These results provide a potential biomarker to identify and follow individuals at high risk for pancreatic cancer after pancreatitis.
Prediction of survival of advanced dementia patients using the advanced dementia prognostic tool: a 2-year prospective study
Authors: Liu Junjin , Li Xuebing , Yu Weihua , Liu Bei , Yu Wuhan , Zhang Wenbo , Hu Cheng , Qin Zhangjin , Chen Yu , Lü Yang 
Published: February 2023

Abstract
Background
There is a lack of research on life expectancy estimation in advanced dementia patients. In this prospective study, we evaluated the usefulness of the advanced dementia prognostic tool (ADEPT) for estimating the 2-year survival of patients in China.
Methods
Patients were recruited from nursing homes and hospitals in Chongqing, China, and followed up for 2 years. The usefulness of the ADEPT score for predicting the 2-year survival rate was evaluated using the area under the receiver operating characteristic (AUROC) curve.
Results
In total, 115 patients were included in the study. Of these patients, 48 died. The mean ADEPT score was 13.0. The AUROC for the prediction of the 2-year mortality rate using the ADEPT score was 0.62. The optimal threshold of ADEPT score was 11.2, which had an AUROC of 0.63, specificity of 41.8, and sensitivity of 83.3.
Conclusions
The ADEPT score based on a threshold of 11.2 was useful to determine the 2-year survival rate of patients with advanced dementia in Chongqing, China. The survival estimation may be used to improve the treatment of patients.
Global attractor for a fractional nonlinear Klein-Gordon-Schrödinger system
Authors: Missaoui Salah 
Published: February 2023

Abstract
We study the long time behaviour of the solutions for aweakly damped forced nonlinear fractional Klein-Gordon-Schrödinger system
iut + iνu − (−∆)αu + vu − |u|2u = f,
vtt+ γvt + (−∆)αv + v+ v3 − |u|2 = g,
for a given α ∈(1/2, 1) considered in the whole space R. We prove that thissystem provides an infinite dimensional dynamical system in Hα(R) × Hα(R) × L2(R) that possesses a global attractor Aα in the same spaceand more particularly that this attractor is in fact a compact subset of H2α(R) × H2α(R) × Hα(R).
Mathematics Subject Classification (2010). Primary 37L30,37L50; Secondary 35A01
Assessement of Diabetes Related-Knowledge and Practice Among Algerian University Students: A Cross-sectional Study
Authors: Lounis Mohamed 
Published: February 2023

Abstract
Background: Diabetes is increasing significantly in the world especially among low and middle income countries including Algeria. It is ranked second in term of incidence in Algeria with about 2.8 million patients of more than 18 years old.
Methods: This study was conducted aiming to evaluate the level of knowledge and lifestyle practice among Algerian university students. A national online based cross-sectional survey was conducted between 14 November 2022 and 11 February 2023 using a self administered questionnaire.
Results: 417 students finally answered to the questionnaire. Demographically, females (82%), singles (86.1%), those aged between 20 and 30 years old (62.2%) and those living in urban areas (86.8%) were the most represented. More than half were students of bachelor level (52.3%) and were mainly studying Natural and Life Sciences (37.2%) and humanities (29.5%) and 10.6% of them declared living with diabetes.
Overall, an acceptable average percentage of 75.1% correct responses was obtained traducing a score of 41.3+7.354/54 and 54.6% of the respondent have shown a high level of knowledge. If age, the field of study and father education were associated with high level of knowledge, Health Sciences students (OR: 10.175, CI 95%: 2.985-34.677) and diabetics (OR: 10.486, CI95%: 3.424-32.12) were so far highly significant factors. Regarding lifestyle practice, a medium level of good practice of 54.2% defining a score of 4.88+1.971/9 was obtained and the level of knowledge was the only associated factor.
Conclusion: These results described that despite the medium to acceptable levels of knowledge and good practice some gaps exists especially among certain categories especially among students other than those of Health and Natural an Life Sciences. Results of this study could be helpful to the health program deciders in their campaigns of prevention against this silent disease.
Domestic Violence against Women and COVID-19 Quarantine: A
Systematic Review Study
Authors: Alamolhoda Seideh-Hanieh , Zare Elham , Doulabi Mahbobeh Ahmadi , Mirabi Parvaneh 
Published: February 2023

Background:
Domestic violence against women is defined as physical, sexual, and emotional
abuse, that women experience. During the COVID-19 quarantine, homes have become very
dangerous places for domestic violence against women.

Methods:
Following PRISMA guidelines, Medline, Scopus, Embase, Google scholar, and web of science
were searched. Two independent authors screened all identified titles, abstracts, and relevant full
texts for inclusion in the systematic review. 7 primary studies that were published between December
2019 and March 2021 were examined. The risk of bias in the retrieved articles was assessed by the
Newcastle–Ottawa Scale.

Results:
During the COVID-19 lockdown, people have experienced different situations that lead to
increasing aggressive behavior with possible trauma and violence, especially against women.

Conclusion:
During the quarantine of the COVID-19 pandemic around the world, we need programs
aimed at preventing acts of domestic violence against women, such as trained multi-disciplinary staff,
including psychologists, sexologists, and clinical psychiatrists.
Locking Mechanism for Connecting Elements of Non-Removable Formwork
Authors: Grechukhin A. N. , Kuts V. V. , Pavlov D. A. 
Published: February 2023

Purpose of research. Locking mechanisms have been widely used to connect elements of vertical formwork structures consisting of metal frames and shields fixed to them. The purpose of the study is to develop the design of the locking mechanism for the elements of removable formwork, which has high technological characteristics. A patent search was conducted for existing design solutions to ensure the connection of elements of removable formwork. It has been revealed that the most common structures used in the locking mechanisms of removable formwork elements are rack-and-pinion structures. The analysis of existing structures is carried out, the shortcomings of existing devices are revealed. It is established that the existing designs of locking mechanisms for connecting elements of removable formwork have low manufacturability of individual elements. In this regard, in order to solve the research problem, the design of the locking mechanism was developed, which ensures the connection of the elements of the removable formwork. A distinctive feature of the application of the new design of the locking mechanism for connecting the elements of removable formwork is the use of a new design of the toothed rail, which is more technologically advanced in manufacturing, compared with existing designs. Another distinctive feature is the use of a wedge with smooth edges, which also increases the manufacturability of the construction of the device for connecting the elements of removable formwork. To achieve this goal, an analytical research method was applied. The use of the proposed design will increase the manufacturability of the manufacture of locking mechanisms for connecting elements of removable formwork. The proposed design of the locking mechanism for connecting the elements of removable formwork, developed as a result of the study, has design features related to operating conditions. These features will be considered as a result of further research.Methods. Simulation modeling methods were used to conduct the experiments.Results. The range of sizes of the main structural elements of the locking mechanism for connecting the elements of removable formwork, ensuring the operation of the device under the action of design loads, is determined.Conclusion. The results of the study showed that the existing designs of locking mechanisms for connecting elements of removable formwork have disadvantages, one of which is the low manufacturability of the devices. The design of the locking mechanism has been developed, which provides higher manufacturability. The proposed device can be used in construction to connect elements of fixed formwork.
Evaluation of the provision of enteral nutrition in critically ill patients receiving mechanical ventilation
Authors: Mayasari Meike , Mahmudah Fella Farikhatul , Perwitasari Silviana , Rahayu Umi 
Published: February 2023

<div class="WordSection1"><p><strong> ABSTRACT</strong></p><p><strong>Background:</strong> Providing enteral nutrition to ICU patients is often challenging, leading to sufficient enteral nutrition that is hardly achieved. This condition is caused by gastrointestinal motility disorder and other complications that often happen during enteral nutrition provision. Therefore, it is important to understand the level of nutritional support and the challenges in the form of interruption during enteral nutrition to critically ill patients receiving mechanical ventilation to optimise the benefit of nutritional support for patients, including reducing the duration of hospitalisation and mortality.</p><p><strong>Objectives:</strong> This study aims to evaluate the provision of enteral nutrition and identify the cause of interruption for patients with mechanical ventilation in one of the tertiary hospitals in Yogyakarta, Indonesia who receive enteral nutrition.</p><p><strong>Methods:</strong> This is a cross-sectional study. The subject of the study is patients who fulfil the inclusion and exclusion criteria. Inclusion criteria include patients who were in ICU for ≥72 hours, receiving mechanical ventilation. While the exclusion criteria include patients with contraindications for enteral nutrition such as unstable haemodynamic, bowel obstruction, persistent severe ileus, gastrointestinal bleeding, nasogastric tube (NGT) placement is not possible, patients receiving oral nutrition with non-invasive ventilation, patients with feeding tube before admission, or patients from other ICU or HCU.</p><p><strong>Results: </strong>Patients needed, on average, 13 hours to receive initial enteral nutrition (SD ± 9.89 hours), with a period between 0 – 50 hours since admission to ICU. The mean time for patients to receive full feeding is 4 days ± 2.4 days. On the other hand, 16 out of 75 patients (21.2%) did not reach the targeted intake during admission. The cause of the interruption of enteral nutrition includes gastric residual volume (GRV), percutaneous dilatation tracheostomy (PDT) procedure, vomiting, bloating, surgery, CT scan, etc.</p><p><strong>Conclusion:</strong> Many causes of interruption and inadequate intake of enteral nutrition can be prevented. The absence of protocol agreed upon by the patient care team could be one of the influencing factors.</p><p><strong>KEYWORD: </strong><em>enteral nutrition; enteral nutrition interruption; mechanical ventilation</em></p><p><em> </em></p></div>
Association Between Social Networking Site Use Intensity and Depression Among Chinese Pregnant Women: Cross-sectional Study
Authors: Wang Rui , Cong Shengnan , Sha Lijuan , Sun Xiaoqing , Zhu Rong , Feng Jingyi , Wang Jianfang , Tang Xiaomei , Zhao Dan , Zhu Qing , Fan Xuemei , Ren Ziqi , Zhang Aixia 
Published: February 2023

Background
Despite extensive debates about the mental health impacts of the use of social networking sites (SNSs), including WeChat, the association and mechanisms between social interaction of WeChat use intensity and antenatal depression are unclear.

Objective
We aimed to test the mediating roles of upward social comparison on social interaction of WeChat and rumination in the association between social interaction of WeChat use intensity and antenatal depression.

Methods
A cross-sectional survey was conducted in four hospitals with the self-reported measures of social interaction of WeChat use intensity, upward social comparison on social interaction of WeChat, rumination, antenatal depression, and control variables. The mediation analysis was performed through Model 6 from the PROCESS macro 4.0 in SPSS 26.

Results
Results from 2661 participants showed that antenatal depression was unrelated to social interaction of WeChat use intensity (P=.54), but was significantly positively related to the attitude toward social interaction of WeChat (P=.01). The direct effect of attitude toward social interaction of WeChat use on antenatal depression was not statistically significant (β=–.03, P=.05). The results supported an indirect relationship between attitude toward social interaction of WeChat use and antenatal depression via (1) upward social comparison on social interaction of WeChat (indirect effect value=0.04, 95% CI 0.03 to 0.06); (2) rumination (indirect effect value=–0.02, 95% CI –0.04 to –0.01); and (3) upward social comparison on social interaction of WeChat and rumination in sequence (indirect effect value=0.07, 95% CI 0.06 to 0.08).

Conclusions
Our findings highlight the necessity of focusing on attitudes toward SNS use, and the importance of upward social comparison and rumination in understanding the effect of SNS use on antenatal depression.