bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARA Title III and Community Hazards Planning: The Case of the Chemical Stockpile Emergency Preparedness Program
Authors: Feldman David Lewis 
Published: January 2023

This paper provides an overview and analysis of the impact of the Superfund Amendments and Reauthorization Act of 1986's Title III provisions (SARA Title III or Title III) on community participation, risk communication, and other elements of effective emergency preparedness for response to accidental hazardous chemical releases. It employs the U.S. Army's Chemical Stockpile Emergency Preparedness Program (CSEPP) as a case study and applies conclusions from this case to other programs. The employment of SARA Title by CSEPP exemplifies recent efforts by emergency planners to integrate disaster research theory into the practice of emergency management. This integration has occurred in three specific areas: (1) disseminating risk information to the public; (2) enhancing intergovernmental coordination; and (3) identifying needed resources and legal reforms for ensuring that emergency response and recovery decisions can be made in a timely manner—free of postemergency litigation.
Reflecting the Hazard or Restating Old Views: Newspapers and Bushfires in Australia
Authors: McKay Jennifer M. 
Published: January 2023

This paper illustrates that in the response and recovery phases of the 1994 Bushfire disaster in New South Wales, Australian and overseas newspaper reporting of the causes of bushfires focussed on scapegoating. The popular scapegoats were arsonists or failure of a public authority to provide fire-breaks. Thus two items were featured whereas the causes of most bushfires are multidimensional and official reports rarely attribute a cause. This paper applies an existing seven-theme classification of the content of newspaper reports to the 1994 event. Newspapers from the local community were examined and two other papers from fire-prone communities in Australia. In addition, reports in two international papers were examined for accuracy. This paper establishes that causes are scapegoated but that accuracy of impact figures is preserved despite the distance.
Properties of blends from pregelatinized starch with poly (vinyl alcohol) for hygienic-purposed disposable laundry bags
Authors: Phattarateera Supanut , Sangthongdee Montree , Threepopnatkul Poonsub 
Published: January 2023

This research was focused on the properties of poly (vinyl alcohol) (PVOH) blended with pregelatinized starch (PSt) as a suitable material to make laundry bags for infected clothes application. PVOH and PSt (0, 10, 20, 30, and 40 wt.%) with glycerol 20 phr were melt-blended by twin-screw extruders. The samples were processed into the film by single layer-blown film extrusion. From the results, it was found that PVOH, glycerol, and pregelatinized starch had intermolecular interactions with each other, forming hydrogen bonding interactions between PVOH/pregelatinized starch and glycerol. The glass transition temperature (Tg) of a blend was shifted to a higher temperature by increasing the pregelatinized starch content leading to a reduction in the percent crystallinity. The presence of pregelatinized starch slightly increased the melt flow rate (MFI)/melt volume rate (MVR), apparent viscosity, and viscosity average molecular weight (Mv) of the blends due to the chain entanglement but it decreased the water solubility time and the moisture content. A co-continuous phase with small coalescence was found when 30% pregelatinized starch was added, increasing the elongation at break to 171%. On the other hand, the pregelatinized starch content was 40%, the elongation at break reduced to 154%.
The fabrication and evaluation of silver nanoparticle-based keratin scaffolds
Authors: Lei Tongda , Fan Jie , Wang Yongheng , Cao Fuyuan , Yang Qingqi , Tian Faming , Li Bo , Su Zhibo , Chen Rouxi , Liu Yong 
Published: January 2023

The biotoxicity caused by focus releasing of Ag, which associated with the Ag loading mode, is a problematic issue that need to be solved for practical utilization of the keratin based wound dressing. In this study, keratin/AgNPs blend scaffolds (Ker/Ag) and keratin scaffolds with AgNPs attached on the scaffold’s wall surface (Ag@Ker) were prepared. Structure and physical properties of the scaffolds were tested and investigated. In comparison to the Ag@Ker scaffolds, the Ker/Ag scaffolds with uniform dispersion of AgNPs have larger tensile strength and slower degradation rate. Both kind of scaffolds present excellent antibacterial property with 10 μg mL−1 AgNPs addition, while the Ker/Ag displayed a linear Ag releasing ratio in the first 5–7 days, which is beneficial for obtaining a continuous antibacterial property and avoiding the biotoxicity caused by focus release of Ag. Correspondingly, cytotoxicity assay further reveals that the continuously slow release of Ag of the Ker/Ag scaffolds accelerated the proliferation of cell. Infectious animal models and histological studies showed that the Ker/Ag scaffolds can effectively inhibit the inflammatory response and accelerate epithelialization. Thus, it can be concluded that the Ker/Ag scaffolds with uniform dispersion of AgNPs are more attractive as wound repair materials.
Reasons for kidney transplant refusal among patients receiving peritoneal dialysis: A qualitative study
Authors: Biabani Fateme , Rahmani Azad , MahmudiRad Gholamhossein , Hassankhani Hadi , Azadi Arman 
Published: January 2023

Background: Even though kidney transplantation has better outcomes compared to dialysis therapies, some patients undergoing peritoneal dialysis (PD) refuse to consider kidney transplantation. Identification of the underlying reason for patient refusal may improve patients’ acceptance of kidney transplantation. Aim: The aim of this study was to describe the reasons given by Iranian PD patients for refusing kidney transplantation. Method: Eighteen patients undergoing PD participated. Data were collected using semi-structured interviews and were analysed using conventional qualitative content analysis. Results: The analysis leads to the emergence of two categories and six subcategories: negative outcomes of kidney transplantation (financial burden, psychosocial problems and physical complications) and doubtful factors for kidney transplantation (negative attitudes towards kidney transplantation, long waiting time for kidney transplantation and compatibility of PD with daily life). The financial burden and long waiting time for kidney transplantation were the most important factors in the reluctance of kidney transplantation by PD patients. Implication for practice: Patients undergoing PD declined kidney transplantation for several reasons, such as financial burden, fear of post-transplantation side effects, long waiting time for kidney transplantation. Reducing the time of kidney transplantation and insurance coverage of transplant costs can change the attitude of PD patients towards transplant.
Daridorexant: Comprehensive Review of A New Oral Agent for the Treatment of Insomnia
Authors: Park Juliane , Render, PharmD Kandon P. , Cates, PharmD Drew W. 
Published: January 2023

Objective: To review the current pharmacology, pharmacokinetics/pharmacodynamics, safety, and efficacy of daridorexant in patients with insomnia. Data Sources: A literature search of PubMed (March 1, 2018, to October 19, 2022) and ClinicalTrials.gov search was conducted using the following terms: daridorexant and ACT-541468. Additional articles were identified by hand from references. Study selection and data extraction: We included English-language articles evaluating daridorexant pharmacology, efficacy, or safety in humans for the management of insomnia. Data synthesis: Daridorexant has a peak plasma concentration of 1-2 hours, terminal half-life of 8 hours, and absolute bioavailability of 61%. Wake after sleep onset (WASO) significantly decreased from baseline to months 1 and 3 in daridorexant 25 (–18.40 and –22.97 min, P < 0.0001) and 50 mg (–28.98 and –29.41 min, P < 0.0001) groups compared with placebo. Latency to persistent sleep (LPS) significantly decreased from baseline to months 1 and 3 for daridorexant 25 mg (–28.17 and –30.73 min, P = 0.0005 and P = 0.0015) and 50 mg (–31.20 and –34.80 min, P < 0.0001). Relevance to patient care and clinical practice in comparison to existing agents: Daridorexant can be administered in diverse patient populations because of its tolerability and favorable safety profile. However, due to the lack of large scale studies that directly compare dual orexin receptor antagonists (DORAs), there is not enough data to recommend 1 DORA over another. Conclusions: Daridorexant is well tolerated and has demonstrated significant reductions in LPS and WASO in the treatment of insomnia in adult patients.
Prediction Performance of Feature Selectors and Classifiers on Highly Dimensional Transcriptomic Data for Prediction of Weight Loss in Filipino Americans at Risk for Type 2 Diabetes
Authors: Chang Lisa , Fukuoka Yoshimi , Aouizerat Bradley E. , Zhang Li , Flowers Elena 
Published: January 2023

Background: Accurate prediction of risk for chronic diseases like type 2 diabetes (T2D) is challenging due to the complex underlying etiology. Integration of more complex data types from sensors and leveraging technologies for collection of -omics datasets may provide greater insights into the specific risk profile for complex diseases. Methods: We performed a literature review to identify feature selection methods and machine learning models for prediction of weight loss in a previously completed clinical trial (NCT02278939) of a behavioral intervention for weight loss in Filipinos at risk for T2D. Features included demographic and clinical characteristics, dietary factors, physical activity, and transcriptomics. Results: We identified four feature selection methods: Correlation-based Feature Subset Selection (CfsSubsetEval) with BestFirst, Kolmogorov–Smirnov (KS) test with correlation featureselection (CFS), DESeq2, and max-relevance-min-relevance (MRMR) with linear forward search and mutual information (MI) and four machine learning algorithms: support vector machine, decision tree, random forest, and extra trees that are applicable to prediction of weight loss using the specified feature types. Conclusion: More accurate prediction of risk for T2D and other complex conditions may be possible by leveraging complex data types from sensors and -omics datasets. Emerging methods for feature selection and machine learning algorithms make this type of modeling feasible.
Demographic, Clinical, and Behavioral Factors Associated With Electronic Nicotine Delivery Systems Use in a Large Cohort in the United States
Authors: Goldberg Scott Shauna , Feigelson Heather S. , Powers John David , Clennin Morgan N. , Lyons Jason A. , Gray Mark T. , Vachani Anil , Burnett-Hartman Andrea N. 
Published: January 2023

Introduction Our primary purpose is to understand comorbidities and health outcomes associated with electronic nicotine delivery systems (ENDS) use. Methods Study participants were Kaiser Permanente (KP) members from eight US regions who joined the Kaiser Permanente Research Bank (KPRB) from September 2015 through December 2019 and completed a questionnaire assessing demographic and behavioral factors, including ENDS and traditional cigarette use. Medical history and health outcomes were obtained from electronic health records. We used multinomial logistic regression to estimate odd ratios (ORs) and 95% confidence intervals (CIs) of current and former ENDS use according to member characteristics, behavioral factors, and clinical history. We used Cox regression to estimate hazard ratios (HRs) and 95% CIs comparing risk of health outcomes according to ENDS use. Results Of 119 593 participants, 1594 (1%) reported current ENDS use and 5603 (5%) reported past ENDS use. ENDS users were more likely to be younger, male, gay or lesbian, and American Indian / Alaskan Native or Asian. After adjustment for confounding, current ENDS use was associated with current traditional cigarette use (OR = 39.55; CI:33.44-46.77), current marijuana use (OR = 6.72; CI:5.61-8.05), history of lung cancer (OR = 2.64; CI:1.42-4.92), non-stroke cerebral vascular disease (OR = 1.55; CI:1.21-1.99), and chronic obstructive pulmonary disease (OR = 2.16; CI:1.77-2.63). Current ENDS use was also associated with increased risk of emergency room (ER) visits (HR = 1.17; CI: 1.05-1.30) and death (HR = 1.84; CI:1.02-3.32). Conclusions Concurrent traditional cigarette use, marijuana use, and comorbidities were prevalent among those who used ENDS, and current ENDS use was associated with an increased risk of ER visits and death. Additional research focused on health risks associated with concurrent ENDS and traditional cigarette use in those with underlying comorbidities is needed.
Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia
Authors: Aliyo Alqeer , Ashenafi Girma , Abduselam Mohammedzen 
Published: January 2023

Background: Rh incompatibility has been an important cause of severe neonatal hyperbilirubinemia, hydrops fetalis, and stillbirth. Among those outcomes, neonatal jaundice is the most common problem. Objective: The study is assessed the prevalence of Rhesus (Rh) negativity and neonatal outcomes among pregnant women who delivered at Bule Hora University Teaching Hospital over a 5-year period from January 2017 to December 31, 2021. Methods: A retrospective study was conducted on 110 women who delivered at Bule Hora University Teaching Hospital (BHUTH) from January 2017 to December 31, 2021. The complete data of the mother’s and neonates’ status were extracted from the registration book of the hospital using checklists. The data were double entered using EpiData version 3 and exported to the Statistical Package for Social Sciences (SPSS) version 26 for analysis. Descriptive statistics to determine prevalence and frequencies were used to describe the study population in relation to relevant variables, and the results are presented in tables and charts. Results: The study shows that the prevalence of Rh D-negative among women who delivered was 6.4% [95% CI: 1.83,10.98]. Among Rh-negative women, 1 (25%) of blood group AB, 3 (6.5%) of blood group O, and 2 (6.1%) of blood group A were Rh-D negative. The distributions of O, A, B, and AB blood groups among pregnant women who delivered this hospital were 41.8%, 30%, 24.6%, and 3.6%, respectively. Out of neonates born to Rh-negative women, 1 (14.3%) was born with jaundice. Of women who delivered at BHUT hospital, 61 (55.5%) did not have a previous delivery, 7 (6.4%) had a previous abortion, 5 (4.5%) stillbirth, 1 (0.9) died after birth, 4 (3.6%) had a birth child weight less than 2.6 kg. Conclusion: The study revealed that the prevalence of Rh-negative was comparable with finding of different similar studies. To reduce Rh incompatibility-related HDN, the government should educate mothers and encourage them as they follow ANC facilities and after delivery to health facilities.
Psychological and psychosocial aspects of major trauma care: A survey of current practice across UK and Ireland
Authors: Olive P , Hives L , Ashton A , O’Brien MC , Taylor A , Mercer G , Horsfield C , Carey R , Jassat R , Spencer J , Wilson N 
Published: January 2023

Introduction Psychological and psychosocial impacts of major trauma, defined as any injury that has the potential to be life-threatening and/or life changing, are common, far-reaching and often enduring. There is evidence that these aspects of major trauma care are often underserved. The aim of this research was to gain insight into the current provision and operationalisation of psychological and psychosocial aspects of major trauma care across the UK and Ireland. Methods A cross-sectional online survey, open to health professionals working in major trauma network hospitals was undertaken. The survey had 69 questions across six sections: Participant Demographics, Psychological First Aid, Psychosocial Assessment and Care, Assessing and Responding to Distress, Clinical Psychology Services, and Major Trauma Keyworker (Coordinator) Role. Results There were 102 respondents from across the regions and from a range of professional groups. Survey findings indicate a lack of formalised systems to assess, respond and evaluate psychological and psychosocial aspects of major trauma care, most notably for patients with lower-level distress and psychosocial support needs, and for trauma populations that don't reach threshold for serious injury or complex health need. The findings highlight the role of major trauma keyworkers (coordinators) in psychosocial aspects of care and that although major trauma clinical psychology services are increasingly embedded, many lack the capacity to meet demand. Conclusion Neglecting psychological and psychosocial aspects of major trauma care may extend peritraumatic distress, result in preventable Years Lived with Disability and widen post-trauma health inequalities. A stepped psychological and psychosocial care pathway for major trauma patients and their families from the point of injury and continuing as they move through services towards recovery is needed. Research to fulfil knowledge gaps to develop and implement such a model for major trauma populations should be prioritised along with the development of corresponding service specifications for providers.
Paradoxes, contradictions, and dilemmas: Reflections on the contours of a pandemic and its implications for social work education
Authors: Brydon Kerry A , McDermott Fiona 
Published: January 2023

Summary This is a reflective and theoretical article that discusses the impact of COVID-19 on social work practice. The pandemic, which made its presence felt globally from early 2020, continues to have ongoing and significant consequences for lives, livelihoods, public health, and personal freedoms. We argue that, while its specific contours are yet to be comprehensively researched, let alone the final outcomes understood, the pandemic has presented opportunities to develop new ways of thinking about social work and social work education. Findings Through a discussion of relevant literature, including a recent work of fiction, we contend that social workers have been able to adapt, to some extent, to the pandemic but in reactive rather than proactive ways. The biopsychosocial and person-in-environment perspectives that characterize social work education, theory, and practice might be greatly enhanced by the introduction of complexity theory in terms of developing new thinking about the theoretical basis of social work, enabling new questions and new strategies to emerge to strengthen social work responses to the challenges posed by COVID-19. Applications Arising from this theoretical article, there are many implications for introducing complexity theory within social work education programs. Complexity theory can provide a conceptual frame fit-for-purpose for social work pandemic and post-pandemic theory and practice.
AGATA: A Toolbox for Automated Glucose Data Analysis
Authors: Cappon Giacomo , Sparacino Giovanni , Facchinetti Andrea 
Published: January 2023

Background: Analyzing continuous glucose monitoring (CGM) data is a mandatory step for multiple purposes spanning from reporting clinical trial outcomes to developing new algorithms for diabetes management. This task is repetitive, and scientists struggle in computing literature glucose control metrics and waste time in reproducing possibly complex plots and reports. For this reason, to provide the diabetes technology community a unified tool, here we present Automated Glucose dATa Analysis (AGATA), an automated glucose data analysis toolbox developed in MATLAB/Octave. Methods: Automated Glucose dATa Analysis is an open-source software program to visualize and preprocess CGM data, compute glucose control metrics, detect adverse events, evaluate the effectiveness of users’ prediction algorithms, and compare study arms. Automated Glucose dATa Analysis can be used as a standalone computer application accessible through a dedicated graphical user interface, particularly suitable for clinicians, or by integrating its functionalities in user-defined MATLAB/Octave scripts, which fits the need of researchers and developers. To demonstrate its features, we used AGATA to analyze CGM data of two subjects extracted from a publicly available data set of individuals with type one diabetes. Finally, AGATA’s features are compared against those of 12 noncommercial software programs for CGM data analysis. Results: Using AGATA, we easily preprocessed, analyzed, and visualized CGM data in a handy way, in compliance with the requirements and the standards defined in the literature. Compared to the other considered software programs, AGATA offers more functionalities and capabilities. Conclusion: Automated Glucose dATa Analysis is easy to use and reduces the burden of CGM data analysis. It is freely available in GitHub at https://github.com/gcappon/agata .
Central nervous system status is prognostic in T-cell acute lymphoblastic leukemia: a Children’s Oncology Group report
Authors: Gossai Nathan P. , Devidas Meenakshi , Chen Zhiguo , Wood Brent L. , Zweidler-McKay Patrick A. , Rabin Karen R. , Loh Mignon L. , Raetz Elizabeth A. , Winick Naomi J. , Burke Michael J. , Carroll Andrew J. , Esiashvili Natia , Heerema Nyla A. , Carroll William L. , Hunger Stephen P. , Dunsmore Kimberly P. , Winter Stuart S. , Teachey David T. 
Published: January 2023

Abstract
To determine the prognostic significance of central nervous system (CNS) leukemic involvement in newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL), outcomes on consecutive, phase 3 Children’s Oncology Group clinical trials were examined. AALL0434 and AALL1231 tested efficacy of novel agents within augmented-Berlin-Frankfurt-Münster (aBFM) therapy. In addition to testing study-specific chemotherapy through randomization, the AALL0434 regimen delivered cranial radiation therapy (CRT) to most participants (90.8%), whereas AALL1231 intensified chemotherapy to eliminate CRT in 88.2% of participants. In an analysis of 2164 patients with T-ALL (AALL0434, 1550; AALL1231, 614), 1564 had CNS-1 (72.3%), 441 CNS-2 (20.4%), and 159 CNS-3 (7.3%). The 4-year event-free-survival (EFS) was similar for CNS-1 (85.1% ± 1.0%) and CNS-2 (83.2% ± 2.0%), but lower for CNS-3 (71.8% ± 4.0%; P = .0004). Patients with CNS-1 and CNS-2 had similar 4-year overall survival (OS) (90.1% ± 0.8% and 90.5% ± 1.5%, respectively), with OS for CNS-3 being 82.7% ± 3.4% (P = .005). Despite therapeutic differences, outcomes for CNS-1 and CNS-2 were similar regardless of CRT, intensified corticosteroids, or novel agents. Except for significantly superior outcomes with nelarabine on AALL0434 (4-year disease-free survival, 93.1% ± 5.2%), EFS/OS was inferior with CNS-3 status, all of whom received CRT. Combined analyses of &gt;2000 patients with T-ALL identified that CNS-1 and CNS-2 status at diagnosis had similar outcomes. Unlike B-ALL, CNS-2 status in T-ALL does not impact outcome with aBFM therapy, without additional intrathecal therapy, with or without CRT. Although nelarabine improved outcomes for those with CNS-3 status, novel approaches are needed. These trials were registered at www.clinicaltrials.gov as #NCT00408005 (AALL0434) and #NCT02112916 (AALL1231).