bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Genetic Variability in Toll-like Receptors (TLR 2, TLR 4, and TLR 9) on Human Immunodeficiency Virus-1 Disease Progression
Authors: Kaushik Gaurav , Vashishtha Richa 
Published: March 2023

Background:
It has been demonstrated that toll-like receptors (TLR2), TLR4, and TLR9 which were initially known for recognizing bacterial products are involved in the detection of viral components. It was planned to undertake a prospective longitudinal study among ethnically homogeneous antiretroviral treatment and antitubercular treatment naïve human immunodeficiency virus (HIV)-positive patients representing the north Indian population. The aim of the study was to investigate the influence of TLR2, TLR4, and TLR9 polymorphism in HIV disease progression.

Methods:
The present study was designed to investigate genetic polymorphism in TLRs (TLR2, TLR4, and TLR9) among HIV-infected patients with and without TB coinfection. The study population consisted of two groups: (i) HIV-positive patients without TB infection and disease (n = 223, HIV-positive patients); (ii) HIV-positive patients with latent tuberculosis infection (LTBI) (n = 150, HIV-positive LTBI patients). These participants were of either gender between 18 and 60 years of age and treatment naïve for both TB and HIV. HIV-positive and HIV-positive LTBI patients were longitudinally followed up for t2 years to study HIV disease progression.

Results:
On comparing TLR2 and TLR4 allelic and genotypic frequencies between 306 HIV-positive patients (no TB/AIDS) and 47 HIV-positive patients progressed to active TB/AIDS, no significant difference was observed between the two groups. The frequency of “A” allele in TLR9 was found to be significantly increased in 47 HIV-positive patients who progressed to active TB/AIDS (61.7%) as compared to 42.16% in 306 HIV-positive patients (no TB/AIDS), (P < 0.001). Furthermore, a significantly increased frequency of “AA” genotype in TLR9 was observed in 47 HIV-positive patients progressed to active TB/AIDS (55.32%) as compared to 20.26% in HIV-positive patients (no TB/AIDS).

Conclusion:
Findings of the present study revealed that genetic variability in TLR9 may influence HIV disease progression. The AA genotype in TLR9 may be associated with progression to TB/AIDS for 2 years in HIV-positive patients.
Evaluation of Endoscopic Septoplasty Outcomes Using Nasal Obstruction Symptom Evaluation Scale
Authors: Basappa Varun TGS , Dutta Angshuman , Naga Rahul , Gupta DK , Mathews Sunil 
Published: March 2023

Inroduction:
Nasal obstruction is the most common complaint in an average ENT practice, and a deviated nasal septum is the most common cause of nasal obstruction. The deformities of the septum are usually congenital, developmental, traumatic, or iatrogenic in nature with traumatic and iatrogenic being the most common. The aim of the study was to evaluate patient-based outcomes on subjective-based opinion in patients undergoing endoscopic septoplasty.

Methods:
This study was conducted in a tertiary care hospital setting in western Maharashtra. This was a prospective observational study. The present study was conducted on 50 patients who presented with signs and symptoms attributed to septal deviation who underwent endoscopic septoplasty and followed up in the department of otorhinolaryngology, head and neck surgery, tertiary care hospital, Mumbai, Maharashtra. The results of our study were analyzed on SPSS Software using “Paired t-test”.

Results:
On the statistical analysis of the Nasal Obstruction Symptom Evaluation score of patients (n = 50) at baseline and at postoperative 3- and 6-month follow-up, mean + standard deviation was 61.2 ± 11.18, 9.1 ± 5.32, and 8.1 ± 4.51, respectively, with P < 0.0001 preoperative and 3-month postoperative follow-up which is highly significant and P > 0.05 for 3- and 6-month follow-up and hence insignificant.

Conclusion:
Endoscopic septoplasty results in significant improvement in disease-specific quality of life with high patient satisfaction.
Penyelesaian Pelanggaran Administrasi Pemilu oleh Bawaslu
Authors: Lefteuw Maksimus , Pattiasina Lidia Priscilla 
Published: March 2023

Introduction: The legal issues in this writing include how are the legal arrangements regarding the settlement of general election administration by Bawaslu and how to resolve election disputes by Bawaslu.
Purposes of the Research: This writing aims to find out and analyze how to resolve violations of general election administration by Bawaslu.
Methods of the Research: The research method used is normative, that is, research that primarily examines positive legal provisions and legal principles, explain and predicts in the direcrion of future legal developments
Results Originality Findings of the Research: The findings of this study prove that in legal arrangements regarding the settlement of election administrative violations by Bawaslu and the settlement mechanism that in an effort to resolve administrative violations, Bawaslu has the authority to resolve administrative violations in accordance with the provisions of the Bawaslu laws and regulations and the General Election Commission. The settlement mechanism based on the Election Law is not explained significantly but it is explained that non-criminal violations are administrative violations and these violations are reported and followed up by Bawaslu and the General Elections Commission.
Dualisme Makna Akta Pengakuan Hutang
Authors: Sinaga Roulinta Yesvery 
Published: March 2023

Introduction: Deed of debt recognition as an authentic deed can be made in two forms, namely as a debt agreement or equivalent to a credit agreement and as an assessor agreement of a credit agreement deed that is grosse deed. Both types of debt acknowledgment deeds are still used in public life, the benefits and functions of each deed are different, because the position is different, the impact of the deed is also different.
Purposes of the Research: The purpose of this research is to see the differences in the actualization of the deed of recognition of debt in practice and to examine the position of the deed of debt recognition and the contribution of each deed in the legal relationship of the parties.
Methods of the Research: This research was conducted in a normative juridical manner, namely by examining the existing secondary data in the field of law as library data which is focused on examining the application of rules or norms in positive law so that the data used by the author is secondary data.
Results Originality of the Research: The dualism of interpreting the meaning of debt recognition basically has the same hope, namely the existence of a legal relationship in debts and receivables, the position deed of debt recognition as an authentic deed has a formal function and the function of evidence, the strength of the debt recognition deed provides perfect evidentiary power. The position of debt recognition as a grosse deed should not be merely a scrap of paper because it requires a follow-up to the imposition of collateral through a separate deed of guarantee, then the debt recognition as an assessor agreement becomes an intermediary deed which seems futile. The dualism of the meaning of this deed of recognition of debt would not occur again and provide a harmonious understanding. if you really want to emphasize it, you should use the term 'debt agreement or credit agreement' which is domiciled as the main agreement, without a grosse deed followed by the binding of special guarantees, both individual and material guarantees for the interests and legal protection of the parties.
Challenges of the Social Economy Action Plan for Greece in the Light of the Socially Responsible Public Procurement
Authors: Lamprinidis Lampros 
Published: March 2023

Purpose: The purpose of the Communication is to present the action plan for the social economy in the European Union. Public procurement is a powerful tool for public authorities to spend public money in an efficient, sustainable and strategic way, especially in times of budgetary constraints (EU Commission, 2017). Annual spending on public procurement in the EU amounts to €2 trillion, so managing it effectively can save significant resources for public budgets and investments, while supporting social and environmental policies. A public procurement strategy requires a change of attitude from public authorities, so that public procurement is no longer seen as a mere administrative process, but as a tool to serve broader objectives and needs, while respecting the rules governing the EU (EU Commission, 2017). With this in mind we will refer to the Action Plan for the Social Economy in the EU (2021) in the light of Socially Responsible Public Procurement in relation to Greece.
Methodology: Concise review of the Action Plan for the Social Economy in EU in the Light of the Socially Responsible Public Procurement. For this reason, we will refer to Socially Responsible Public Procurement, European policies supporting the Social Economy, and the EU Action Plan for its development. Then we will refer to the Public Procurement Strategy in Greece from the point of view of supporting Social Economy Entities.
Findings: Presentation of the challenges of the Public Procurement Strategy in Greece in relation to Socially Responsible Public Procurement and the Social Economy Action Plan by extension
Unique Contribution to Theory Practice and Policy: The contribution of this paper is to inform stakeholders in Greece on the implementation of the Social Economy Action Plan of EU and its link to Socially Responsible Public Procurement. Through this link, the development of Social Economy Organisations can be supported on the one hand and on the other hand it can contribute to the sustainable development of the European economy and of Greece in particular.
A comparison of partial repair with arthroscopic margin convergence suture and open superior capsular reconstruction in patients with massive rotator cuff tear
Authors: Gulcu Anil , Dincer Recep 
Published: March 2023

IntroductionMassive rotator cuff tears (MRCTs) remain a controversial problem for clinicians. There are several recommendations in the literature, from various surgical techniques to the effectiveness of conservative treatment. In this study, we aimed to compare clinical outcomes and functional results of open superior capsular reconstruction for massive rotator cuff tear and arthroscopic partial rotator cuff repair with margin convergence.Material and methodsThis study included 40 patients with massive rotator cuff tears that could not be treated with arthroscopic partial repair with margin convergence or open superior capsular reconstruction. The patients were divided into 2 groups according to the treatment method. Patient assignments for each group were not randomized. Group 1 consisted of 20 patients who underwent open superior capsular reconstruction, and Group 2 comprised 20 patients who underwent arthroscopic partial repair. UCLA (University of California Los Angeles), CS (Constant shoulder score) scores, and the visual analogue pain scale (VAS) were used to evaluate the clinical outcomes of the patients.ResultsAt the time of the latest follow-up evaluation, both groups showed significant improvements in clinical outcomes (<i>p</i> < 0.05). There were no significant differences in the clinical outcomes between groups. The preoperative tear size was statistically significantly higher in the superior capsular reconstruction group (<i>p</i> < 0.05).ConclusionsOur results supported the benefits of arthroscopic and open surgical technique with similar clinical results in the treatment of massive rotator cuff tear. We think that arthroscopic partial repair may be preferred by surgeons because it is minimally invasive compared to open superior capsular reconstruction.
Pembrolizumab (Keytruda)
Authors: CADTH  
Published: March 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses pembrolizumab (Keytruda), 200 mg, IV infusion.
Indication: For the treatment of adult patients with persistent, recurrent, or metastatic cervical cancer whose tumours express PD‐L1 (CPS ≥ 1) as determined by a validated test, in combination with chemotherapy with or without bevacizumab.
Low-Cost Civil Structure Health Monitoring Using Wireless Sensor Network
Authors: Wiqar Tousiq , Khattak Khurram Shehzad , Malik Haroon , Khan Zawar Hussain 
Published: March 2023

This research presents a low-cost, real-time, reliable, and scalable solution for Structural Health Monitoring.(SHM) using an IoT-based multi-node system. The study's objective is to detect and identify damages timely andweaknesses in civil structures such as bridges, buildings, and dams, which environmental factors, overuse, or natural phenomena may cause. Each sensor node, fabricated using NodeMCU, is equipped with sensors for measuring vibration, shock, tilt, strain, humidity, and temperature. The data collected by multiple sensor nodes is transmitted to Amazon Web Services (AWS) cloud platform via Wi-Fi and analyzed for damage detection and predictive maintenance. The field testing on a pedestrian steel bridge showed over 99% success in data transmission with a frequency of 1 second per reading, resulting in 18,000 readings over 5 hours. With a fabrication cost of $40 per sensor node and scalable AWS resources, the proposed solution is highly scalable and can operate for 15 days without human intervention.
2022 Award for Best Article in NAMES: A Journal of Onomastics
Authors: Nick I. M. 
Published: March 2023

For more than a decade, the American Name Society has singled out an outstanding article to be given the Best Article of the Year Award. To select the publication to receive this prestigious honor, each member of the Editorial Board independently reviewed all of the articles that had been published in 2022. As per ANS tradition, obituaries, notes, editorials, book reviews, and articles contributed by the Editor-in-Chief were excluded from consideration. To make their decision, Board Members were asked to select the publications which they felt possessed the highest degree of creativity; demonstrated the best writing style; employed the soundest research methodology; and had the greatest potential to make a lasting and significant contribution to onomastics. Then, in a secret ballot, the Board members cast their votes. This report details the results of that selection process and reveals the 2022 winner of the ANS Best Article of the Year award.
Analisis Determinan Kejadian Stunting Pada Balita Usia 1 – 5 Tahun di Wilayah Kerja Upt Puskesmas Saripoi
Authors: Cintami Elvita , Hatini Erina Eka , Herlinadiyaningsih Herlinadiyaningsih 
Published: March 2023

Usia balita merupakan masa dimana proses pertumbuhan dan perkembangan terjadi sangat pesat. Salah satu permasalahan gizi yang sering terjadi adalah stunting. Stunting merupakan satu dari beberapa masalah gizi yang dialami oleh balita didunia. Penelitian bertujuan untuk Menganalisis Determinan Kejadian Stunting pada Balita Usia 1-5 Tahun. Metode Penelitian Pengambilan data kuantitatif menggunakan pendekatan Cross Sectional Cara pengambilan sampel pada penelitian ini menggunakan non probability sampling dengan consecutive sampling. Jumlah sampel sebanyak 60 responden. Berdasarkan hasil uji statistik chi square, terdapat hubungan yang signifikan antara faktor pendidikan ibu dengan kejadian stunting (P value = 0,011); terdapat hubungan yang signifikan antara pekerjaan ibu dengan kejadian stunting (p value = 0,001); terdapat hubungan yang signifikan antara faktor pendapatan ayah dengan kejadian stunting (P value = 0,022); dan terdapat hubungan yang signifikan antara faktor riwayat penyakit dengan kejadian stunting (p value = 0,017). Pendidikan ibu, pekerjaan ibu, pendapatan ayah, dan riwayat penyakit berpengaruh terhadap kejadian stunting di wilayah Kerja UPT Puskesmas Saripoi.
The Experiences of Parental Divorce on the Psychological Well-Being among High School Students
Authors: Jiarui Ma , Che Amat Muhammad Asyraf 
Published: March 2023

High school students in China who have experienced parental divorce may face significant psychological and life challenges. The purpose of this study is to explore and understand the impact of parental divorce on the psychological well-being among Chinese high school students. This qualitative study adopted a descriptive phenomenological approach. A total of eight participants were selected through a purposive sampling technique in Qinghai Province, China. The data was gathered using a semi-structured interview to gain in-depth understanding and to obtain sufficient information from the participants. The research data were collected to answer two research questions: 1) what are the experiences of high school students from parental divorced families? 2) how does parental divorce affect high school students’ psychological well-being? The following themes were identified in high school students who experience parental divorced in their families: 1) difficulties adapting with new family environment, 2) becoming overly independent, and 3) rising economic problems after the divorce. Four themes were also identified on how parental divorce experiences affect students’ psychological well-being: 1) low life satisfaction and happiness, 2) emotional instability, 3) sense of insecurity, and 4) arising of mental health risks and problems. The study will prepare organizations that provide mental health services and school counsellors to a better understanding of the thoughts, feelings, and behaviours of high school students who are affected by parental divorce and provide them with necessary supports.
Rejecting “Nature” inMartin Chuzzlewit: Racism, Slavery, and Death in Eden
Authors: Armstrong James 
Published: March 2023

ABSTRACTIn Martin Chuzzlewit, Charles Dickens skewers the use of nature as a justification for vice, instead inviting readers to rise above their baser impulses, be those tendencies “natural” or not. This article looks at how nineteenth-century discourses of America as a natural paradise influenced Dickens’s depiction of the land, its inhabitants, and the political institutions taking root there in the 1840s. The novel’s critique of the role of nature in American life reached a crescendo with Martin’s arrival in Eden, a town linked by its name to a pro-nature ideology. Dickens’s rejection of Eden is a rejection not just of the United States, but of what he saw as the naïve and self-interested acceptance of “nature” as a replacement for complex moral thought. This critique is reiterated in the murder plot involving Jonas Chuzzlewit and is central to Dickens’s attack on selfishness and the many evils it generates, including fraud, violence, and slavery.
Twenty-First-Century Oscar Wilde: A Review Essay
Authors: Kaye Richard A. 
Published: March 2023

ABSTRACTThis article focuses on developments in critical, cultural, literary, and biographical understandings of Oscar Wilde over the last twenty-two years as well as in recent film adaptations drawing on his writing and life. In addition to noting the many new scholarly editions of his writing, the article focuses on six major areas of interest in Wilde over the last two decades: Wilde as a figure in Victorian Sexual History, where he assumes both central and subsidiary roles; Wilde as biographical subject, in which some biographers depict him as a serious artist and thinker while other biographers view him as complicit in his own criminal downfall; Wilde as a the twentieth- and twenty-first century cultural precursor of the American Pop artist Andy Warhol but also as a figure who transcends Warholian aesthetics as Wilde comes to represent a denied sentimentality, especially evident in recent cinematic adaptations; Wilde as a global figure whose writing and influence have resonated powerfully outside of Britain; Wilde and the critical approach known as the New Formalism, in which Wilde’s so-called art-for-art’s sake philosophy and practice are taken seriously; Wilde as he has come to assume a prominent place in the critical field known as the New Decadent Studies, in which the Decadent movement that Wilde helped to inaugurate emerges as far more than a short-lived, largely British phenomenon associated only with the 1880s and 1890s and that supposedly died with the successful prosecution of the playwright in 1895.
Dark, and Dear, and Passionate Desire: Before and After the Feast at Shushan
Authors: Tracy Steven C. 
Published: March 2023

ABSTRACT
This article is a comparative close reading of two poems, one from the nineteenth century by Frances Ellen Watkins Harper, the other a dramatic monologue from the twentieth century by Anne Spencer. The poems both deal with the abuse of patriarchal power in the story of Queen Vashti, contextualizing the story in both centuries, showing how, with masks firmly in place, women writers delivered powerful messages of protest to the male communities using an ancient story that speaks powerfully to their present as well as ours.
Either War Is Finished or We Are: Why Herman Wouk’s Duology Deserves a Second Look
Authors: Pickus David 
Published: March 2023

AbstractThis article seeks to reinvigorate critical discussion of Herman Wouk by focusing on his two massive war novels, The Winds of War (1971) and War and Remembrance (1978). Although well known in his lifetime, Wouk has received only limited academic exposition. His memory is bifurcated between a popular readership that continues to turn to Wouk for entertainment and instruction, and his reception in academic reviews, which is primarily critical, and sometimes hostile. Missing is an account of the methods Wouk used to fuse history and fiction, as well as an exploration of how Wouk’s novels expressed his values. Addressing this gap, this article explores (1) the difference between the image of Wouk and the record of his writing; (2) his adoption of a stance based on biblical prophetic ideals, done to expose a “Thucydidean” political world; and (3) the seriousness of his commitment to using war novels in the service of future peace. Wouk earned an important place in American Holocaust literature. His duology also provides Jewish American letters of an interesting example of the reconceptualization of tropes of Victorian fiction as a means of confronting the contemporary world’s grimmest realities. He deserves a second look.
Kurikularni modeli u predškolskim sistemima-komparativni aspekti
Authors: Novović Tatjana 
Published: March 2023

Kurikulumi u predškolskim institucijskim okvirima čine suštinsku potku za razvijanje cjelovitog vaspitno-obrazivnog procesa. Uslovljeni različitim teorijsko-naučnim i tradicijsko-kulturloškim odrednicama, u kontekstualnim praksama, kurikulumi dobijaju jedinstvene okvire i pravce razvoja. U okrilju savremene holistički orijentisane socio-konstruktivističke paradigme, sagledavali smo zajednička i polja distnktivnih obilježja šest kurikularnih predškolskih modela. U osnovi prikazanih modela nalazimo veoma bliske temeljne principe i ciljeve, kojima se afirmiše dječja dobrobit. S druge strane, pozicija predškolskog segmenta u predstavljenim sistemima se u određenim aspektima razlikuje, pa nalazimo u svakom od modela određene specifičnosti, koje deriviraju iz paradigmatskih i kultoroloških odrednica pojedinih obrazovnih miljea, naglašavajući neke od strukturnih dimenzija ili razvijajući dominatno kontekstualni pristup razvoju kurikuluma.