bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Então Gargalha e Falha têm um som parecido, né?”:
Authors: FRANÇA ANA CLÁUDIA DE , COSTA-MACIEL DÉBORA AMORIM GOMES DA 
Published: January 2025

De que modo o trato docente com a consciência fonológica, explorada no contexto da “loa de maracatu”, pode colaborar para o aprendizado do sistema de escrita alfabética? Esse questionamento impulsiona este artigo, cujo objetivo é o de analisar estratégias didáticas direcionadas para o desenvolvimento da consciência fonológica, no âmbito do gênero textual “loa de maracatu”, vivenciadas no contexto da Educação de pessoas Jovens, Adultas e Idosas (EJAI) de uma escola da Rede Municipal localizada na Zona da Mata Norte de Pernambuco. Aportadas nos estudos de Morais (2010; 2012; 2019) e Soares (2018), destaca-se, nas atividades analisadas, a identificação de palavras com as sílabas iniciais parecidas (aliteração); as semelhanças nas sílabas finais das palavras (rimas), assim como a relação entre a pauta sonora e a escrita. Os dados foram tratados sob um prisma qualitativo (Minayo, 2012), a partir de elementos da técnica de análise de conteúdo categorial (Bardin, 1977). O cenário revelou um trabalho significativo, o trato com a consciência fonológica, aos moldes abordados, oportunizou o envolvimento dos/as alunos/as com o gênero em questão, possibilitou atividades favoráveis a apropriação do sistema de escrita alfabética, ao mesmo tempo em que enalteceu a cultura de um grupo que milita por espaço e valorização.
A formação continuada de professores alfabetizadores:
Authors: Arcenio Cláudia Rodrigues do Carmo , Bastos Azevedo Patrícia 
Published: January 2025

Este texto traz uma análise sobre os programas federais de formação continuada, para professores alfabetizadores, desenvolvidos no período que abrange 1990 a 2020. O recorte temporal deve-se às premissas educacionais alinhavadas internacionalmente que priorizavam a formação em serviço, sendo um referencial para os programas formativos que se avolumam a partir da década de 1990. Assim, exploramos os aspectos da formação continuada para esse público específico, apresentando um resumo da estrutura e das diretivas que essas formações buscaram trazer para a alfabetização no decorrer desses trinta anos. Neste artigo, abordamos seis programas, a saber: os Parâmetros Curriculares Nacionais em Ação (PCN em Ação); o Programa de Formação de Professores Alfabetizadores (PROFA); o Pró-Letramento; o Pacto Nacional pela Alfabetização na Idade Certa (PNAIC); o Mais Alfabetização e; o Tempo de Aprender. Procuramos trazer apontamentos que auxiliam em suas caraterizações de forma a explicitar as concepções de alfabetização e letramento que os circundaram e que intentaram arraigar às práticas alfabetizadoras.
Upregulation of hsa_circ_0000745/hsa_circRNA_101996 in peripheral blood monocytes is associated with coronary heart disease
Authors: Li Shanshan , Shi Miaomiao , Gele Teri , Zhang Aimin , Li Wenyi , Sun Yi , Wang Chunyan , Zhao Jie , Pei Lin , Liu Jian , Jia Mei 
Published: January 2025

Abstract

Objectives
Circular RNAs (circRNAs) are known to be associated with cardiovascular diseases. At present, an ideal biomarker for the early diagnosis of coronary heart disease (CHD) is still lacking.

Methods
We screened differentially expressed circRNAs (DEcircRNAs) in the peripheral blood monocytes (PBMCs) of patients with CHD, using the microarray technology in comparing the transcriptome. We identified upregulated and downregulated circRNAs. At the same time, we collected the patient clinical medical records and the PBMCs, the above results were analyzed and validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), using 374 patients.

Results
We identified 183 upregulated and 41 downregulated circRNAs. Among these DEcircRNAs, hsa_circ_0000745/hsa_circRNA_101996 was significantly upregulated in a cohort of 297 patients with CHD and 77 non-CHD controls. Among patients with CHD, hsa_circ_0000745/hsa_circRNA_101996 was significantly upregulated in the unstable angina pectoris (UAP) and acute myocardial infarction (AMI) subgroups compared to the stable angina pectoris (SAP) subgroup. By dividing hsa_circ_0000745/hsa_circRNA_101996 expression into quartiles, we observed that the highest hsa_circ_0000745/hsa_circRNA_101996 expression quartile was a risk factor for CHD compared to the lowest quartile (odds ratio [OR]: 2.709; 95 % confidence interval [CI]: 1.126–6.519, p=0.026), after adjusting for the traditional risk factors (age, sex, body mass index [BMI], smoking, alcohol, C-reactive protein [CRP], small and dense low-density lipoprotein [sdLDL] and lipoprotein-associated phospholipase A2 [LP-PLA2]).

Conclusions
These data suggest that upregulated hsa_circ_0000745/hsa_circRNA_101996 in PBMCs is a risk factor for CHD and could be used as a biomarker of CHD.
Mechanism, models, and influence of heterogeneous factors of the microarc oxidation process: A comprehensive review
Authors: Pecherskaya Ekaterina , Golubkov Pavel , Konovalov Sergey , Gurin Sergey , Novichkov Maksim 
Published: January 2025

Abstract
The shortcomings of the microarc oxidation (MAO) technology are revealed, in accordance with which a range of topical scientific problems that need to be solved is formulated. It is shown that, despite significant progress in this area of research, there are still controversial issues related mainly to the features of the emergence and combustion of microdischarges. In order to develop a scientifically substantiated approach to the choice of the optimal mode for deposition of microarc oxide coatings, regularities in the influence of heterogeneous factors on their properties are systematized. The analysis of scientific works devoted to the mathematical description of the MAO process has been carried out. It is shown that the existing mathematical models have limitations, and are applicable only to certain aspects of coating formation and do not describe the MAO process as a whole. The prerequisites, recommendations, and theoretical provisions that can be used in the development of a complex mathematical model of the MAO process are revealed. Known methods of analytical description of the forming curve are considered. The possibility of using the forming curve for determining the correct choice of technological parameters and predicting the oxide coating properties during their formation is shown.
Resource Utilization and Cost in Management of Febrile Infants After the 2021 Clinical Guideline
Authors: Dingle Elena , Pelletier Jonathan H. , Forbes Michael L. , Rajbhandari Prabi 
Published: January 2025

OBJECTIVE
The 2021 American Academy of Pediatrics clinical practice guideline (CPG) for well-appearing febrile infants aims to promote evidence-based care, reduce practice variability, enhance care quality, and optimize cost. We aimed to examine the trends in resource utilization and cost associated with the evaluation and management of febrile infants aged 8 to 60 days before and after the CPG’s publication.

METHODS
We performed a retrospective cross-sectional study using the Pediatric Health Information Systems Database, covering the periods of August 2019 to July 2021 (pre-CPG) and August 2021 to July 2023 (post-CPG). We analyzed the use of antibiotics, acyclovir, laboratory studies, lumbar punctures (LPs), and hospitalizations before and after the CPG publication.

RESULTS
We identified 33 736 encounters (12 220 pre-CPG and 21 516 post-CPG). After the CPG, there was a decrease in hospitalization (42.6% vs 34.7%, −7.9% [−9.0% to −6.8%]), antibiotic and acyclovir administration (41.9% vs 33.1%, −8.8% [−9.9% to −7.7%]; 9.7% vs 7.3%, −2.4% [−3.1% to −1.8%]), and LP (31.7% vs 21.8%, −9.9% [−10.9% to −8.9%]). Conversely, the use of C-reactive protein (23.7% vs 32.3%, 8.6% [7.6% to 9.5%]) and procalcitonin (40.1% vs 64.5%, 24.4% [23.3% to 25.5%]) increased. Cost remained unchanged. Age-stratified analysis revealed a significant reduction in hospitalization, antibiotic use, and LP in infants aged older than 22 days, whereas infants younger than 28 days experienced a slight increase in delayed diagnosis of bacteremia and sepsis after the CPG.

CONCLUSIONS
After the CPG, hospitalization, antimicrobial use, and LPs decreased in infants aged older than 22 days, indicating that the CPG may be effective in reducing resource utilization. There was a slight increase in delayed diagnosis of bacteremia and sepsis in infants younger than 28 days.
Pogled na izvajanje brezšivne skrbi v regionalni bolnišnici – kvalitativna raziskava
Authors: PEVEC TEODOR , REPEC SABINA 
Published: January 2025

Koncept brezšivne skrbi je v Sloveniji novost zadnjih let. Pomeni pomembno vključitev kliničnih farmacevtov pri neposrednem delu z bolniki in prispeva k bolnikovi varnosti. V polni obliki se v naši ustanovi izvaja dobro leto. Zanimal nas je pogled kliničnih farmacevtov na nov način dela. Izvedli smo kvalitativno raziskavo. Potrebne informacije smo pridobili s pomočjo intervjujev, ki smo jih izvedli s štirimi kliničnimi farmacevti, ki imajo največ teoretičnega in praktičnega znanja s področja brezšivne skrbi. Intervjuvanci menijo, da je implementacija brezšivne skrbi v klinično prakso pomembna in pozitivna. Motijo jih administrativne ovire pri izvajanju brezšivne skrbi. Zaznava kliničnih farmacevtov je primerna in omogoča razvoj metode še na ostale poklicne skupine.
ANALISIS PENGARUH PROFIL SUDUH TERHADAP DAYA TURBIN VORTEX
Authors: Marfizal Marfizal , Sufiyanto Sufiyanto , Wardianto Dedi 
Published: January 2025

Turbin vortex adalah turbin yang beroperasi dengan memanfaatkan aliran vortex sebagai penggerak sudu-sudu turbin yang kemudian poros turbin dihubungkan ke generator untuk mengkonversi energi mekanis poros kedalam bentuk energi listrik. Pada penelitian ini akan dilakukan pengujian terhadap turbin vortex dengan head 1 m, debit aliran 0,12 m3/s. dalam proses pengujian akan di gunakan 3 jenis sudu, yaitu sudu lurus, sudu lengkung dan sudu lengkung bersirip. Setelah dilakukan pengujian dapat disimpulkan bahwa daya tertinggi terdapat pada sudu lengkung sebesar 959,08 watt dan berikutnya sudu lengkung bersirip 714.38 watt, sedang kan daya terendah terdapat pada jenis sudu lurus 582.48 Watt. Untuk putaran yang dihasilkan dapat terlihat pada grafik dibawah, Putaran tertinggi terdapat pada sudu lengkung bersirip sebesar 540,00 rpm dan berikutnya sudu lengkung 517.67 rpm, sedang kan putran terendah terdapat pada jenis sudu lurus 510.67 rpm. Untuk effisiensi masing masin sudu terhat bahwa sudu lengkung masih tertinggi dan diikuti sudu jenis lengkung bersirip, terendah sudu lurus dengan effisiensi masin masin 98 %, 73 % dan 59%.
Low-dose Rivaroxaban versus Warfarin in Patients Early after Bioprosthetic Valves Replacement
Authors: Guo Rui , Luo Ying , Wang Shuwei , Liu Zhifang , Zhang Dan , Hou Leping , Xing Mengyu , Xu Shuang , Luo Dan 
Published: January 2025

Abstract

This study aims to evaluate the effects of low-dose rivaroxaban in patients during the initial three months following bioprosthetic valve replacement. In this retrospective study, we compared low-dose rivaroxaban (15 mg once daily) with dose-adjusted warfarin (target international normalized ratio of 2.0 to 3.0) in patients who received a bioprosthetic valve replacement within the first three months. Primary efficacy outcome was the incidence of thromboembolic complications, while primary safety outcome was the incidence of bleeding within three months post-surgery. A total of 380 patients were enrolled at a large teaching hospital. The primary efficacy outcome occurred in 1 patient in both the warfarin and the rivaroxaban groups (p < 0.001 for noninferiority). There were no deaths in either group. 19 patients experienced the primary safety outcome; specifically, bleeding events occurred in 7 patients in the rivaroxaban group and in 12 patients in the warfarin group (7/178 vs. 12/189, p < 0.001 for noninferiority). After propensity score matching, the prevalence of clinical thromboembolic events was comparable between the two groups (1/130 vs. 0/130, p < 0.001 for noninferiority). The incidence of bleeding events in the rivaroxaban group was found to be noninferior to that in the warfarin group (6/130 vs. 6/130, p < 0.001 for noninferiority). In the early three months following bioprosthetic valve replacement, low-dose rivaroxaban demonstrated noninferiority to warfarin with respect to the incidence of primary outcomes (death, major cardiovascular events, or major bleeding).
AI and Blockchain For Next-Generation E- Governance: A Comprehensive Bibliometric Review In Smart City Innovation
Authors: Lubis Sandi , Nurmandi Achmad , Ahmad Jamaluddin , Purnomo Eko Priyo , Purwaningsih Titin , Jovita-Olvez Hazel D. 
Published: January 2025

Abstract

The merging of AI and blockchain technologies offers essential potential for e-governance, especially in improving predictive policy execution within smart cities. This study thoroughly reviews and assesses existing literature to clarify trends, key publications, and research gaps. Using detailed bibliometric analysis, we explored peer-reviewed articles from well-respected publishers indexed by Scopus, concentrating on works published from 2019 to 2024. Our results reveal an increasing volume of research examining the separate applications of AI and blockchain in e-governance. However, there is a noticeable lack of empirical studies focusing on their combined implementation. Major themes identified include the possibility of improved transparency and efficiency in public services, issues related to interoperability, and ethical considerations about data privacy and algorithmic accountability. This study is constrained by its dependence on bibliometric methods, which may not entirely reflect the practical complexities of technology integration across various governance contexts. Future research should emphasize longitudinal case studies and pilot initiatives to evaluate real-world uses of AI and blockchain in e-governance, addressing regulatory and ethical challenges to promote responsible adoption. This work adds to the global discussion on digital governance, providing a foundational framework for advancing AI and blockchain-enabled smart city projects.
KIFC1 overexpression promotes pancreatic carcinoma progression via stabilizing BUB1
Authors: Fu Xiaowei , Cui Ao , Yu Ying-Xue , Wang Ji-Yang , Zou Ye-Qing , Zhu Ya-Qiong , Ran Long-Jian , Zhang Yu , Liu Rui-Xiang , Dong Mingyi , Wang Hui , Fang Lu 
Published: January 2025

Abstract

Pancreatic cancer (PC) is a highly lethal tumor of the gastrointestinal tract. New molecular targets are urgently needed for its treatment. Kinesin family member C1 (KIFC1) is implicated in the development and progression of several types of cancer. Previously, our studies indicated that KIFC1 is overexpressed in hepatocellular carcinoma and activates the malignant behavior of hepatocellular carcinoma through the PI3K/AKT pathway. However, the molecular and functional mechanisms of KIFC1 in PC have not been investigated. In this study, KIFC1 and BUB1 were significantly upregulated in PC patient samples, and high KIFC1 expression was closely associated with the malignant phenotype and poorer overall survival (OS) in PC patients. Functional experiments showed that KIFC1 knockdown inhibited PC cell growth in vivo and in vitro, blocked cell cycle progression, and hindered cell migration invasion. In addition, reply experiments showed that KIFC1 induced PC cell malignant behaviors dependent on BUB1. Mechanistically, KIFC1 regulates BUB1 expression by competitively binding to BUB1 and reducing its ubiquitination and degradation. We have shown for the first time the molecular regulatory mechanism between KIFC1 and BUB1 in PC Therefore, KIFC1 shows promise as an attractive therapeutic target for PC in the future.
Robust Conductivity of Goldene Against Structural Defects and Mechanical Deformations: A First-Principles Study
Authors: Berdiyorov G. R. , Aissa B. 
Published: January 2025

Abstract

One of the principal challenges in flexible and stretchable electronics is identifying materials that maintain high electrical conductivity under mechanical deformations. Low-dimensional materials like graphene offer substantial benefits due to their mechanical robustness and inherent high conductivity. However, their electrical performance is significantly compromised by mechanical stresses and structural defects such as vacancies and dislocations. Here, we study the effects of structural defects and mechanical deformations on the electronic transport properties of goldene, a single layer of hexagonally arranged gold atoms, to explore its potential for flexible electronics. Our quantum transport calculations reveal that goldene maintains its conductivity effectively, exhibiting only a 1.7% reduction in conductance under a tensile strain of 5%. Additionally, the introduction of single and divacancy defects results in conductance reductions of only 2% and 3%, respectively. Most importantly, goldene’s conductivity remains robust under both bending and twisting, distinguishing it from graphene and positioning it as an outstanding candidate for flexible nanoelectronics.
Post-operative endophthalmitis following routine photorefractive keratectomy (PRK) with succinylcholine anayphlyaxis and extrusion of ocular contents during therapeutic penetrating keratoplasty (PKP)
Authors: Power Barry , Crawford Alex , Wang Michael , Subbiah Shanu 
Published: January 2025

Abstract

Background
Endophthalmitis is an exceptionally rare but devastating complication following laser corneal refractive surgery.
Case Presentation
We present a case of Pseudomonas aeruginosaendophthalmitis following routine myopic photorefractive keratectomy with mitomycin C application. The patient was referred to a tertiary ophthalmic service with severe post-operative infectious keratitis following initial management at another centre and was treated with intensive fortified antibiotics. The eye subsequently developed endophthalmitis with corneal perforation necessitating urgent pars plan vitrectomy facilitated by a temporary keratoprosthesis and subsequent therapeutic penetrating keratoplasty. During anaesthetic induction, the patient developed life-threatening anaphylaxis, most likely secondary to succinylcholine. Aggressive posterior positive pressure was encountered intraoperatively resulting in spontaneous extrusion of the iris and crystalline lens. We postulate that the posterior positive pressure was caused by several factors, including massive inflammation, and fluid shifts secondary to anaphylaxis and its associated management. The positive pressure was successfully managed and a keratoprosthesis was secured allowing completion of vitrectomy and therapeutic penetrating keratoplasty. At 6-month follow-up, the vision remains at light perception
Conclusion
Endophthalmitis is an exceptionally rare but devastating complication following laser corneal refractive surgery, and the use of mitomycin C might have contributed to the rapid progression observed in the current case. Our report also highlights that acute anaphylaxis and its management can lead to posterior positive pressure, and measures should be taken to reduce the potential impacts before intraocular surgery and full-thickness incisions are made.
Pengaruh Citra Merek, Harga Dan Layanan Purna Jual Terhadap Keputusan Pembelian Konsumen
Authors: Dianati Fahima Ilma , Yuniarinto Agung 
Published: January 2025

The use of smartphones, particularly the Apple brand, has dominated the market in Indonesia and Malang City due to the need for information access and the strong branding appeal. Technological advancements, internet availability, and a high number of students are also key factors contributing to the increased smartphone usage in the city. This study aims to determine the influence of brand image, price, and after-sales service on the purchase decision of iPhone users. The research employed a quantitative method with an explanatory approach. Data for this study were collected through a survey distributed to 240 respondents using Google Forms and offline questionnarie. The criteria for respondents in this study were a minimum age of 17, residing in Malang City, and being iPhone users. The data obtained from the questionnaire survey were analyzed using Multiple Linear Regression analysis with IBM SPSS 26 software. The results of the research indicate that brand image and after-sales service have a positive and significant impact on the purchase decisions of smartphones with the iPhone brand. However, price does not affect the purchase decisions of iPhone brand smartphones. The conclusion drawn from this research is that an increase in brand image and after-sales service will enhance the purchase decisions of iPhone users in Malang City.

Abstrak
Penggunaan smartphone, terutama merek Apple, mengalami dominasi di Indonesia dan Kota Malang berkat kebutuhan akan akses informasi dan daya tarik branding yang kuat. Perkembangan teknologi, ketersediaan internet, dan jumlah mahasiswa yang tinggi juga menjadi faktor utama dalam peningkatan penggunaan smartphone di kota tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh citra merek, harga, dan layanan purna jual terhadap keputusan pembelian pengguna iPhone. Penelitian ini menggunakan metode kuantitatif dengan pendekatan eksplanatori. Data dari penelitian ini dikumpulkan dari survei dengan menyebarkan kuesioner dalam jaringan menggunakan Google Form dan kuisioner offline ke 240 responden. Kriteria responden yang dibutuhkan dalam penelitian ini adalah berumur minimal 17 tahun, berdomisili di Kota Malang, dan pengguna iPhone. Data yang diperoleh dari penyebaran kuesioner dianalisis menggunakan analisis Regresi Liner Berganda dengan perangkat lunak SPSS IBM 26. Hasil penelitian menunjukkan bahwa citra merek dan layanan purna jual memiliki pengaruh positif dan signifikan terhadap keputusan pembelian smartphone dengan merek iPhone. Disamping itu, harga tidak berpengaruh terhadap keputusan pembelian smartphone merek iPhone. Kesimpulan dari penelitian ini adalah apabila citra merek dan layanan purna jual meningkat, maka akan meningkatkan keputusan pembelian pengguna iPhone di Kota Malang.