bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory Potency of UDA Lectin on Neovascularization: A Biomolecule for Carbohydrate-Mediated Targeting of Angiogenesis
Authors: Samadian Esmaeil , Colagar Abasalt Hosseinzadeh , Safarzad Mahdieh , Asadi Jahanbakhsh , Mansouri Kamran 
Published: December 2022

Abstract
Background
Cellular vascularization processes including proliferation, migration, and tube formation are selectively the purpose of current angiogenic inhibitors. In this study, we investigated the impact of Urtica dioica agglutinin (UDA) on the cellular vascularization processes events.
Methods and Results
Different concentrations of UDA were treated on various normal (HUVEC, MCF-10A and HDF from human and L-929 from mouse) and cancer (A431 and U87 from human and 4T1 from mouse) cell lines at different times. The MTT, cell migration assay, differentiation of endothelial cells, and expression of VEGF-A/VEGF-R2 and integrin α2 were evaluated. The MTT results demonstrated that UDA was non-toxic on normal cells whereas this lectin was able to prevent the growth of neoplastic cells. The migratory capacity of HUVECs and U87 Glioblastoma cells was inhibited by UDA in wound repair model. This lectin was a preventive agent for HUVECs-induced vessel sprouting in Collagen-cytodex matrix. Also, down-regulation of the VEGF-integrin cross-talk in HUVECs under the UDA treatment confirmed the anti-angiogenic activity of this molecule.
Conclusions
Based on our findings, UDA may have an effect on the proliferation of cancer cells and vascularization events with minimal toxicity on normal cells through binding glyco-conjugates which bear GlcNAc/Man oligomer like EGFR. This is a blue clue for the angiogenesis-related therapeutic importance of UDA.
The Impact of Sarcopenia on Overall Survival in Patients with Pan-RAS Wild-type Colorectal Liver Metastasis Receiving Hepatectomy
Authors: Yang Yao-Ren , Shi Chung-Sheng , Chang Sheng-Wei , Wu Yu-Ying , Su Yu-Li , Lin Geng-ping , Kuan Feng-Che 
Published: December 2022

Abstract
Background
Sarcopenia has been associated with conventional chemotherapy-related toxicity, postoperative complications and poor overall survival in patients with genotype-unselected metastatic colorectal cancer (mCRC). This study aimed to evaluate the prognostic implications of sarcopenia and its change after perioperative cetuximab plus doublet chemotherapy and hepatectomy in patients with RAS wild-type colorectal liver metastasis (CRLM).
Methods
Patients with CRLM from 2007 to 2018 in Chang Gung Research Database were retrospectively analyzed. Baseline characteristics as well as skeletal muscle index (SMI) at baseline and dynamic changes after interventions were collected. A multivariate Cox proportional hazard model was used to evaluate the effect of each parameter on overall survival (OS), and the Kaplan-Meier method was used to establish survival curves. A two-sided p value < 0.05 was considered statistically significance.
Results
Of 214 RAS wild-type mCRC patients who received both cetuximab and doublet chemotherapy, 77 who received upfront or subsequent hepatectomy were included in this study. The median follow-up time was 2.3 years. The rate of sarcopenia was higher in the patients who received neoadjuvant cetuximab-containing regimens than in those who received upfront hepatectomy (95% versus 63%, p = 0.001). Increased SMI after perioperative systemic therapy remained independently associated with better OS in multivariate analysis [hazard ratio (HR) = 0.88/10% increase, p = 0.013). The patients with sarcopenia had a trend of worse OS than those without sarcopenia (median OS: 4.5 versus 3.6 years, log-rank p = 0.282).
Conclusions
Improvement in sarcopenia ([SMI after intervention – initial SMI]/initial SMI x 100%) is an important prognostic factor for OS. Future research is warranted to investigate direct interventions for sarcopenia and the impact on OS.
The risk of being bitten by a dog is higher on hot, sunny, and smoggy days
Authors: Dey Tanujit , Zanobetti Antonella , Linnman Clas 
Published: December 2022

Abstract
Humans commit more violent crimes when temperature and air pollution is higher. Here, we investigate if also the day-to-day rates of dogs biting humans is influenced by environmental factors. 69,525 reports of dogs biting humans, sourced from public records on animal control requests and from ER records, were analyzed. The impact of temperature and air pollutants were evaluated with a zero-inflated Poisson generalized additive model, while controlling for regional and calendar effects. Exposure-response curves were used to assess the association between outcome and major exposure variables. We find that the rates of dogs biting humans increases with increasing temperature and ozone, but not PM2.5 exposure. We also observed that higher UV irradiation levels were related to higher rats of dog bites. We conclude that dogs, or the interactions between humans and dogs, are more hostile on hot, sunny, and smoggy days, indicating that the societal burden of extreme heat and air pollution also includes the costs of animal aggression.
Regular bi-interpretability of Chevalley groups over local rings
Authors: Bunina Elena 
Published: December 2022

Abstract
In this paper we prove that if $G(R)=G_\pi (\Phi,R)$ $(E(R)=E_{\pi}(\Phi, R))$ is an (elementary) Chevalley group of rank $> 1$, $R$ is a local ring (with $\frac{1}{2}$ for the root systems ${\mathbf A}_2, {\mathbf B}_l, {\mathbf C}_l, {\mathbf F}_4, {\mathbf G}_2$ and with $\frac{1}{3}$ for ${\mathbf G}_{2})$, then the group $G(R)$ (or $(E(R)$) is regularly bi-interpretable with the ring~$R$.As a consequence of this theorem, we show that the class of all Chevalley groups over local rings (with the listed restrictions) is elementary definable, i.\,e., if for an arbitrary group~$H$ we have $H\equiv G_\pi(\Phi, R)$, than there exists a ring $R'\equiv R$ such that $H\cong G_\pi(\Phi,R')$.
KindnessbyPost: An Economic and Clinical Evaluation of a Participatory Public Mental Health Intervention
Authors: Novere Marie Le , Clarke Caroline S , Jones Rebecca , Warran Katey , Lloyd-Evans Brynmor , Rains Luke Sheridan 
Published: December 2022

Abstract

Background
#KindnessbyPost (KbP) is a “national kindness exchange”. Participants send and receive a card by post to different, unknown people containing messages of good will. Previous evidence suggests participation in KbP may improve loneliness and wellbeing. We evaluated the outcomes and associated costs of KbP and explored the feasibility of collecting health economic measures for future research.
Methods
We used a pre-post, observational study design. Participants in two KbP exchanges in 2021 were invited to complete an online questionnaire. It included self-reported measures of psychological wellbeing and loneliness, capability, and healthcare service use. Data were collected at three time-points: exchange start (baseline), exchange-end (2 weeks), and 3-months post-exchange. Additional cost data were obtained from the KbP programme organisers.
Results
Across exchanges, baseline data were obtained for 1,285 participants (from 1,142 individuals). In total, 623 (48%) of participants were followed up at exchange-end, and 414 (32%) at 3-months. 70% of participants were aged between 31 and 60 (n = 789). 94% of participants were female (1,075) and 95% of white ethnicity (1,078). Compared to baseline, loneliness and wellbeing improved at exchange end (‑0.21, 95% CI: -0.29 to -0.12; 0.68, 0.47 to 0.88 respectively) and at 3 months follow up (-0.40, -0.50 to -0.30; 1.01, 0.77 to 1.25 respectively). We observed no difference from baseline in capability at both follow up points (mean (SD) at baseline: 0.52(0.22); exchange-end: 0.53(0.22); 3-months: 0.53(0.22)). The average cost of delivering the intervention was £0.67–0.87 per participant.
Conclusions
We observed a small, sustained improvement to people’s wellbeing and loneliness following participation in a KbP exchange. Given the study design, causal attribution to KbP is uncertain. However, our results are consistent with previous evaluations and offer preliminary evidence that KbP may be an effective mental wellbeing intervention. Given its cheap cost (estimated at £0.67-£0.87 per participant) and highly scalable design, KbP could be an effective and cost-effective intervention for improving public mental health, which warrants definitive evaluation of effectiveness and cost-effectiveness in future. Our study also demonstrates the feasibility of collecting the wellbeing and health economic outcome measures needed for this research.
Isolation and Identification of Edwardsiella Tarda from Fish in Haramaya Lake, East Hararghe Zone, Oromia Regional State, Ethiopia
Authors: Abdurezak Nuredin , Yusuf Balisa , Lulseged Leykun 
Published: December 2022

Abstract
Background
Edwardsiellosis is a serious systemic bacterial disease of Edwardsiella tarda which is known for causing diseases in humans, reptiles, amphibians, marine mammals and other warm-blooded animals. E. tarda is the most important diseases causing bacteria that leade to severe economic losses in fish farms of many countries due to its admirable effects on a variety of fish taxa including carp, tilapia, eel, catfish, mullet, salmon, trout and flounder. This study aimed on isolation and identification of E. tarda from the fishes (Catfish and Tilapia) of Lake Haramaya:
Methods
A cross-sectional study design was conducted from December 2021 to May 2022 to estimate the occurrence and distribution of Edwardsiella tarda from the kidney, spleen, liver and intestine of apparently healthy fish in the Lake Haramaya, Eastern Ethiopia. From a total 384 of swab and tissue samples were randomly taken from the kidney, liver, spleen and intestine of 96 apparently healthy fish (Clarias gariepinus and Oreochromis niloticus) originating from Lake Haramaya, 18 showing similar colony and biochemical characteristics to E. tarda were isolated and identified.
Results
Distribution of E. tarda infection among the four organs examined indicated that E. tarda was isolated most frequently from intestine 10 (10.4%) followed by liver 4 (4.2%) then kidney 2 (2.1%) and spleen 2 (2.1%) with statistically significant difference (P < 0.05) among organs. E. tarda was isolated more frequently from males 12 (26.7%) than females 6 (11.8%) and differences in the occurrence of E. tarda infection with respect to sex was not significant (P > 0.05) indicating that both sexes are equally susceptible. Concerning fish species E. tarda is more frequently isolated from Catfish than tilapia with no significant difference (P > 0.05).
Conclusion
The recovery of E. tarda from Lake Haramaya, which is potentially pathogenic to humans, from the organs and alimentary tracts of fish suggests that fish either improperly handled, undercooked or consumed raw may cause Edwardsiellosis in susceptible individuals and potential threat to both fishery sector/aquaculture. There is limited knowledge of E. tarda infection in fish and humans in the area and hence further awareness to have information on the agent is forwarded.
A g-C3N4/PVDF-based composite polymer electrolytes for sodium-ion battery
Authors: Shu Kewei , Zhou Jiazhen , Wu Xiaojing , Liu Xuan , Sun Liyu , Wang Yu , Tian Siyu , Niu Huizhu , Duan Yihao , Hu Guangyu , Wang Haihua 
Published: December 2022

Abstract
PVDF based polymer solid electrolytes are one of the most promising choices for all-solid-state sodium ion batteries and sodium metal batteries. However, neat polymer solid electrolytes suffered from relatively low ionic conductivity at room temperature, narrow electrochemical stability window. In this work, g-C3N4 nanosheets are introduced as a novel nanofiller for PVDF-HFP based composite solid polymer electrolytes. The g-C3N4 filler can engineer the PVDF-HFP structure, resulting in reduced decreased crystallinity. Additionally, the surface atoms of the g-C3N4 interact with groups in the sodium salt, promoting further dissociation of the sodium salt. The incorporation of g-C3N4 improves the electrical properties (ionic conductivity, Na+ transference number and electrochemical window), mechanical properties and thermal stability of the composite electrolyte. The composite electrolyte shows a low Na deposition/dissolution overpotential of about 100 mV at a current density of 1 mA cm− 2 after 160 cycles. The sodium metal battery with g-C3N4 composite electrolyte and NVP cathode exhibits lower polarization voltage (90 mV), and stable reversible capacity of 93 mAh g− 1 after 200 cycles at 1C.
An efficient scientific workflow scheduling on multi-cloud environment using adaptive golden eagle optimization
Authors: S Immaculate Shyla , T Beula Bell , C Jaspin Jeba Sheela 
Published: December 2022

Abstract
Cloud computing is a model for new technologies and the ability to deliver consistent cloud services. One of the essential features of cloud computing is the provision of "unlimited" computing resources to users on demand. However, single cloud-holding resources are generally limited and may not be able to cope with the sudden surge in user needs. So, the multi-cloud concept is introduced to support resource sharing between the clouds. These days, providing assets and administrations from multiple clouds is becoming an undeniably inspiring worldview. Traditional research in scheduling in the cloud is aimed at improving the cost or makespan. Nevertheless, the reliability of work process scheduling is a fundamental concern and, surprisingly, the main measure of QoS. Therefore, in this paper, multi-objective scheduling for a logical work process in a multi-cloud environment is proposed, the point of which is to control the work process while at the same time cost and makespan while fulfilling the requirement of reliability. To achieve this concept adaptive golden eagle optimization (AGEO) algorithm is designed. The validation of the proposed algorithm takes solution encoding, fitness calculation, and updating functions. For experimental analysis, different workflow model is used and performance is evaluated using different metrics.
Performance, characteristics, and microscopy of fabricated nanozirconia on the composite cement
Authors: Heikal Mohamed , Mohamed Sahar 
Published: December 2022

Abstract
This investigation aimed to study the influence of prepared nanozirconia particles (NZ) on the characteristics, microscopy, and photocatalytic efficiency of composite cement. The average crystallite size of prepared NZ is ≈ 7-15nm. Surface area, pore volume, and pore radius recorded using BET isotherm are 88.01m2/g, 0.12cm3/g, and 4.92nm respectively. The combined water (Wn) and gel/space ratio (X) increased upto 1.5% NZ, these values increased upto 3months than the neat paste. Compressive strength (CS), and bulk density (BD) increased upto 0.25% NZ, whereas the total porosity represented the lower values. Increasing the content of NZ to 0.50-1.00%, the CS decreased, but it nevertheless larger than neat-OPC paste. The correlation results between CS and X values of mix NZ1 represented the higher values than the data of other NZ-composite- pastes. Cement containing 1.5% NZ achieved the highest dye degradation% at 3,7, 28, 90days were 82.34%, 84.72%, 88.58%, 97.22% after 300min of UV-irradiation the photocatalytic degradation.
Unique features of the arterial Blood-Brain Barrier
Authors: Bell Batia , Anzi Shira , Sasson Esther , Ben-Zvi Ayal 
Published: December 2022

Abstract
CNS vasculature differs from vascular networks of peripheral organs by its ability to tightly control selective material exchange across capillary barriers. Capillary permeability is mostly defined by unique cellular components of the endothelium. While capillaries are extensively investigated, the barrier properties of larger vessels are understudied. Here, we investigate barrier properties of CNS arterial walls. Using tracer challenges and various imaging modalities, we discovered that at the mouse cortex, the arterial barrier does not reside at the classical level of the endothelium. The arterial wall’s unique permeability acts bi-directionally; CSF substances travel along the glymphatic path and can penetrate from the peri-vascular space through arteriolar walls towards the lumen. We found that caveolae vesicles in arteriole endothelial and smooth-muscle cells are functional transcytosis machinery components, and that a similar mechanism is evident in the human brain. Our discoveries highlight vascular heterogeneity investigations as a potent approach to uncover new barrier mechanisms.
FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma
Authors: Li Xiaoxu , Lu Juntao , Liu Lei , Li Fei , Xu Tongxin , Chen Liying , Yan Zhaoyang , Li Yan , Guo Wei 
Published: December 2022

Abstract
The transcription factor forkhead box K1 (FOXK1) has recently been recognized to mediate a wide range of biological progresses, including cell proliferation, differentiation, cell cycle progression, apoptosis, DNA damage, and tumorigenesis. However, the role and molecular mechanisms of FOXK1 in esophageal squamous cell carcinoma (ESCC) progression and in the response to ionizing radiation (IR) have not been well characterized. In this study, we investigated the expression level, clinical significance, biological role, and molecular mechanism of FOXK1 in ESCC. High expression level of FOXK1 was observed in ESCC cell lines and tissues, which was correlated with TNM stage, invasion depth, and lymph node metastasis. In addition, overexpression of FOXK1 promoted ESCC cells proliferation, migration, and invasion, whereas silencing FOXK1 showed the opposite effect. Moreover, Silencing FOXK1 enhanced radiosensitivity by inhibiting DNA damage repair, inducing G1 arrest and apoptosis. Further studies revealed that FOXK1 activated transcription of CDC25A and CDK4 in ESCC cells by directly binding to their promoter regions. Furthermore, knockdown of CDC25A or CDK4 reversed those biological processes mediated by overexpression of FOXK1. Collectively, FOXK1, as well as its downstream target genes CDC25A and CDK4, may be potential therapeutic and radiosensitizing targets for ESCC.
Bioanalytical validated Spectrofluorimetric Method for the Determination of Prucalopride succinate in Human Urine Samples and Its Greenness Evaluation
Authors: Saad Marwa T. , Zaazaa Hala E. , Fattah Taghreed A. , Boltia Shereen A. 
Published: December 2022

Abstract
An economical & eco-friendly spectrofluorometric technique has been developed for the determination of prucalopride succinate (PRU) in human urine on the basis of drug’s native fluorescence. The type of solvent and the wavelengths of excitation and emission have been carefully selected for optimal experimental conditions. In deionized water, the fluorescence intensity was measured at λ emission 362 nm upon excitation at 310 nm. This bio-validated method was carried out using 30uL urine without carrying out any preliminary steps. The calibration curve for PRU shows a linear relationship in a concentration range of 0.75–5.5µg/mL. The validation of this proposed technique obeys EMA Guidelines for validating bioanalytical methods and the greenness assessment was evaluated according to the Analytical GAPI approach.
Money laundering and illegal trafficking of waste: evidence from the Italian provinces
Authors: MIGHELI Matteo , OLIVA Maria 
Published: December 2022

Abstract
Money laundering and waste-related crimes are widely studied by the literature. However, few attention has been paid to the connection between the latter and the former. Using Italian data at provincial level, the analysis presented here shows that also waste-related crimes generate illegal proceeds that increase the flows of dirty money that needs laundering. Moreover, evidence about cross-provincial spillovers is provided. Fighting money laundering and following dirty money (perhaps also internationally) may help decreasing illegal waste disposals and traffics, decreasing the yields generated by these crimes.
JEL Codes: K32, Q53
Team training with Mixed Reality and Virtual Reality – benefits and limitations in educational practice illustrated by the example of two paramedic classes
Authors: Elsenbast Christian , Dahlmann Philipp , Schnier Dominik Schnier 
Published: December 2022

Abstract

Background
Case simulations as an imitation of clinical experience are an accepted learning method in health professions. This is also the case in Emergency Medical Services. In the field of case simulations, a strong trend toward the use of more technology has been observed for years, such as the use of Extended Reality. This paper analyzes specific media perception factors and the motivation of paramedic trainees in Extended Reality. It also analyzes the differences in media perception and motivation resulting from the inclusion of a haptic patient manikin in the Extended Reality and its meaning for educational practice.
Methods
The participants were assigned to either the experimental group (Mixed Reality with manikin) or the comparison group (Virtual Reality without manikin) on a class-by-class basis. After an Extended Reality case simulation, a survey was performed using a questionnaire to elicit side effects, sense of presence, motivation, and sociodemographic variables. After evaluating the sociodemographic data, parametric tests were used for mean comparison and correlation analysis.
Results
20 participants were evaluated in the experimental group and 16 in the comparison group. In both groups, high motivation, an acceptable sense of presence, and advanced usability were observed. Sickness symptoms were present. In both groups, high correlation between the two motivation dimensions Identified Regulation and Intrinsic Regulation with Spatial Presence and Usability was found. Spatial Presence and Usability were also significantly correlated in both groups. A significant mean score difference was found for Amotivation between the experimental group (mean = 1.56/6, SD = 1.25) and the comparison group (mean = 2.36/6, SD = 1.14).
Discussion
VR and MR are a promising learning method if implemented in a planned manner by a competent simulation crew. This can be concluded from the participants’ high level of self-regulated motivation as well as from the identified media perception factors. We recommend that the simulation crew use setup checklists, but also a competence-oriented approach, considering fiction contract and structured debriefing. Use of wireless head-mounted-displays and data-gloves still need to be done.