bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Factors affecting the application of the value-based care principle in patient care among sixth-year medical students and postgraduate trainees
Authors: Sornsenee Phoomjai , Choomalee Kittisakdi , Sanphet Kamonlak , Keereerak Kanyarat , Wongwatthanawisit Techin , Wongtabpabut Tanyamon , Tipphayawong Panpim , Khunjun Panupong , Tularak Suppanita , Sungkaro Kanisorn , Wongkittithaworn Theepat 
Published: January 2023

Abstract
Background: Value-based care (VBC) entails improving the quality and value of healthcare for patients by focusing on costs, quality of healthcare services, and quality of life, holistically. The theory of planned behaviour (TPB) is a psychological model outlining individuals’ intentions and behaviours towards VBC to understand how individuals engage in a specific behaviour. Thus, we developed a questionnaire based on VBC and TPB to collect data from sixth-year medical students and postgraduate trainees to identify and compare factors affecting the intention and application of the VBC principle in patient care between these two groups.
Methods: Cross-sectional study (December 2022January 2023) data were collected and analysed using descriptive statistics for personal factors; Spearman rank correlation statistics explored the relationship based on TPB between the score of attitudes towards behaviour, subjective norms, perception of behavioural control, intention to perform behaviour, and application of principles; and a multiple regression analysis was conducted to examine the predictive factors among variables.
Results: This study involved 90 participants, 51 (56.67%) postgraduate trainees and 39 (43.33%) undergraduate students. Spearman rank correlation found relationships between each part of TPB, showing a significant difference in behaviour scores between the two groups. In the multiple regression analysis, attitude and perception scores were positive predictors of intention scores, while postgraduate status, perception scores, and perception of family socio-economic status were significant, positive predictors of behaviour scores. A subgroup analysis revealed that perception scores were positive predictors of both intention and behaviour scores for both groups. Furthermore, being a sixth-year student with a family member suffering from a chronic illness was positively associated with higher behaviour scores (β= 6.28, p-value 0.003). In the postgraduate group, attitude scores and perception of family socio-economic status were correlated with intention scores (β= 0.36, p-value 0.018) and behaviour scores (β=4.14, p-value 0.002).
Conclusions: TPB is a suitable theoretical basis for examining factors influencing the adoption of VBC. Additionally, the perception of behavioural control significantly affects the intention to perform behaviour related to the application of principles in patient care among sixth-year medical students and postgraduate trainees.
Neural substrates for hand and shoulder movement in healthy adults: A functional near infrared spectroscopy study.
Authors: Bonnal Julien , Ozsancak Canan , Monnet Fanny , Valery Antoine , Prieur Fabrice , Auzoy Pascal 
Published: January 2023

Abstract
Characterization of cortical activation patterns during movements in healthy adults may help our understanding of how the injured brain works. Upper limb motor tasks are commonly used to assess impaired motor function and to predict recovery in individuals with neurological disorders such as stroke. This study aimed to explore cortical activation patterns associated with movements of the hand and shoulder using functional near-infrared spectroscopy (fNIRS).
Twenty healthy, right-handed participants were recruited. Two 10-s motor tasks (right-hand opening-closing and right shoulder abduction-adduction) were performed in a sitting position at a rate of 0.5 Hz in a block paradigm. We measured the variations in oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) concentrations. fNIRS was performed with a 24-channel system (Brite 24®; Artinis) that covered most motor control brain regions bilaterally.
Activation was mostly contralateral for both hand and shoulder movements. Activation was more lateral for hand movements and more medial for shoulder movements, as predicted by the classical homunculus representation. We also found ipsilateral activation for both tasks. Both HbO2 and HbR concentrations varied with the activity.
Our data confirm that unilateral movements require bilateral activation of the sensorimotor cortex with stronger activation of the contralateral cortex. We also showed that fNIRS can distinguish patterns of cortical activity in upper limb movements under ecological conditions. These results suggest that fNIRS could be used to measure spontaneous motor recovery and rehabilitation-induced recovery after brain injury.
The trial was restropectively registered on January 20, 2023: NCT05691777 (clinicaltrial.gov)
A Coupling Model of Vertical Rolling Process Based on Upper Bound Method and Elastic Theory
Authors: Yang Boxin , Xu Haojie , An Qi 
Published: January 2023

Abstract
Vertical rolling is an important plastic forming process of metal. The establishment of accurate mechanical model is essential for parameter presetting and online control of the process. A prediction model of vertical rolling force with consideration of mechanism displacement is proposed. Using Γ function and parabolic function to describe edge deformation, the corresponding 3D velocity field, strain rate field and total power functional are derived. On this basis, an energy model for calculating rolling force and edge deformation is established. Simultaneously, an analysis method of mechanism displacement is proposed. The deflection of vertical roller and the radial displacement of support bearings are calculated by applying superposition principle and Palmgren's modified formula respectively. The coupling calculation of slab deformation and mechanism displacement is realized through repeated iteration. The study of bearing structure is carried out, of which the results show that the fluctuation of rolling force caused by bearing azimuth can be ignored. The accuracy of the presented model is verified by comparison with other models and factory measurements. Subsequently, the influences of main rolling parameters on rolling process are analyzed and a series of results are obtained. The influence of width reduction rate and slab thickness on edge deformation and rolling force is greater than that of vertical roller radius and slab width. The compensation value of rolling force has a similar change trend to the compensation value of displacement. In the rolling position, the axis displacement is much greater than deflection. The proportion of axis displacement in total radial displacement rises at first and then falls with the increase of width reduction rate and slab thickness. The proposed model could provide some references for the optimization of vertical rolling process and the improvement of slab quality and yield ratio.
As proficient as adults: Distribution of children's knowledge of wild edible plants in the arid Mahafaly region, Madagascar
Authors: Porcher Vincent , Li Xiaoyue , Carrière Stéphanie M. , Alvarez-Fernandez Santiago , Cresson Didie , Reyes-García Victoria , Gallois Sandrine 
Published: January 2023

Abstract

In drylands, where resources are scarce, wild edible plant (WEP) knowledge is crucial to overcome food scarcity. Understanding the distribution pattern of local ecological knowledge (LEK) about WEP and identifying knowledge holders are key steps to assessing the resilience and vulnerability of knowledge systems. However, little is known about how WEP knowledge is distributed across life stages and gender of people living in arid regions. Here, we study the distribution of WEP knowledge within a small-scale society from southwestern Madagascar, a region known for its dry climate and related food crises. We worked with Tanalana male and female children and adults using semi-structured interviews and free listings. Tanalana people display a sophisticated LEK adapted to the extreme environment in which they live, with a distinct distribution pattern regarding theoretical and practical knowledge across life stages and gender. While women and men cited similar WEP, children and adults cited different sets of WEP, suggesting they hold differentiated bodies of theoretical knowledge, however our results suggest similarity in practical knowledge across life-stage and gender. We argue that resource limitation and food scarcity might be so pervasive in the area that extensive sharing of knowledge on WEP could be an adaptation to the extremely dry environment.
Effect of aluminum honeycomb core milling defects on mechanical properties of sandwich structure
Authors: Wu Shaodi , Liu Chang , Zhang Tianxing , Li Chao , Duan Chunzheng 
Published: January 2023

Abstract
The honeycomb core sandwich structure has received wide attention in aeronautical and aerospace engineering in recent years, which is a structural composite material formed by adding an aluminum honeycomb core layer between two thin metal plates. The honeycomb core has high rigidity in the axial direction, but low rigidity in the radial direction, so many machining defects may easily take place under the action of the horizontal cutting force. To investigate how such defects affect the mechanical properties of aluminum honeycomb core sandwich structure, the mechanical response of honeycomb cores in a flat compression and the deformation process in a low-velocity impact were studied. By milling the aluminum honeycomb cores, the typical defects such as honeycomb wall tearing, folding, crushing, cracking, and debonding were obtained. In addition, a finite element model of the honeycomb sandwich structure with machining defects was created to simulate the flat compression and the low-velocity impact. Then the effects of machining defects on the impact properties under different impact conditions were compared and analyzed. The results show that the tearing has the greatest influence on the flat compression of the aluminum honeycomb core, the length and number of the tearing defect together affect the load carrying capacity of the sandwich structure, however the influences of the crushing and folding, cracking and debonding of the honeycomb wall are small. When the tearing length was 0.3L (L is the length of the honeycomb core wall) and tearing defect ratio was maintained below 8%, the ultimate load applied on the honeycomb sandwich structure and the energy absorption were less affected by the impact energy. The panel thickness has a great influence on the impact performance of the honeycomb sandwich structure, the greater panel thickness of the sandwich structure of the aluminum honeycomb core provides a greater ultimate load capability and a smaller influence of the machining defects on the impact performance of the sandwich structure, with a comprehensive consideration of both lightweight design and reducing the influence of the number of defects on the impact performance of the sandwich structure, the best choice of the skin panel thickness for the honeycomb core was 1 mm.
Performance and wear mechanisms of coated PCBN tools in high-speed turning superalloy GH4202
Authors: Wang Zhanghao , Wang Yongguo , Lv Dejin , Yu Xin , Gao Yuan 
Published: January 2023

Abstract

Nickel-based superalloys are widely used in aerospace and other fields for their superior performance. PCBN is an excellent tool material for cutting superalloys because of its excellent cutting performance. To study the wear mechanism of PCBN tools with different coatings (Uncoated, TiN, and TiAlN) for machining superalloy GH4202 under different cutting conditions, cutting tests were carried out at a wide range of cutting speeds (vc=50-400m/min). Two different cutting conditions, dry cutting, and wet cutting were also introduced. The results showed that the coating can reduce tool wear in dry cutting at a range of speeds (vc =50-200m/min). The coating has the opposite effect when cutting coolant is added. Wear mechanisms vary at different cutting speeds. At high cutting speeds (vc =200-400m/min) coatings and cutting coolant have little effect on tool wear. The TiN coating is the most sensitive to the cutting coolant and the uncoated tool is the most stable. Significant deposition of wear products can be observed at high cutting speeds with the addition of cutting coolant.
Using the serum LDH level as a biomarker for amyopathic dermatomyositis with interstitial lung disease: A retrospective study of 158 patients with nonspecific interstitial pneumonia or organizing pneumonia
Authors: Ying Yanan , Wu Tingting , Wang Long , Zhang Yun , Yu Yiming , Deng Zaichun , Ding Qunli 
Published: January 2023

Abstract
Background
Lactate dehydrogenase (LDH) is an easily obtained biological marker and a promising index for determining the severity of amyopathic dermatomyositis with interstitial lung disease (ADM-ILD). In this study, we retrospectively analysed the clinical signs and laboratory data from ADM-ILD patients displaying nonspecific interstitial pneumonia (NSIP) or organizing pneumonia (OP) ILD radiological patterns, and we identified the serum LDH level as a useful biomarker for early ADM-ILD detection.
Methods
In our cohort study, 158 Chinese patients were divided into four groups according to whether NSIP or OP patterns were present on high-resolution computed tomography (HRCT). The 4 groups included 25 ADM-NSIP and 92 control-NSIP patients, 15 ADM-OP patients, and 29 control-OP patients. Patient’s demographic features, clinical presentation, laboratory parameters, duration of ILD, and follow-up data were recorded and analysed.
Results
ADM-ILD patients generally had higher AST (45.96 ± 42.45 in NSIP, 64.53 ± 75.75 in OP, U/L) and LDH (317.20 ± 104.29 in NSIP, 356.60 ± 214.84 in OP, U/L) levels than the corresponding control groups. A total of 40.53% (15/37) and 86.49% (32/37) of ADM-ILD patients had high serum levels of AST and LDH above the normal range, respectively. At a cut-off level of 235.5 U/L, identified by the ROC curve, serum LDH yielded a sensitivity of 78.38% and specificity of 82.64% for ADM with NSIP or OP radiological patterns. The 5-year overall survival rate of ADM-OP patients (73.33%) was significantly worse than that of control-OP patients (94.12%) (p=0.007). No difference was evident in the survival rate between the NSIP groups. The presence of skin ulcers (p=0.028) and OI<300 mmHg (p=0.029) were significant risk factors for poor outcomes in ADM-ILD patients. A lower serum level of ferritin (< 500 ng/ml) indicated a better patient prognosis (p=0.023). The presence of coexistent myositis-associated autoantibodies with anti-melanoma differentiation-associated gene 5 (anti-MDA5) seems to protect ADM-ILD patients.
Conclusions
The LDH level can be used as a screening biomarker for patients with NSIP or OP ILD radiological patterns. It is important to recognize ADM-ILD early, especially in patients with the OP radiological pattern, which appears to impact patient treatment and outcomes.
Afterhours telehealth in Australian residential aged care facilities: A mixed methods evaluation
Authors: TRANKLE STEVEN A , REATH JENNIFER 
Published: January 2023

Abstract
Background
The aged care system in Australia is failing. Residential aged care facilities (RACFs) and general practitioners (GPs) struggle to meet the care demands of their residents, particularly after hours. Many residents are given ambulance support and transferred to hospital emergency departments (EDs) for care that could be provided at RACFs. The MyEmergencyDoctor (MED) service was commissioned in a 12-month program (February 2020-February 2021) using ED physicians to provide afterhours telehealth care in six RACFs.
Methods
We conducted descriptive analyses of statistical data from the MED service, RACFs and the ambulance service and conducted a thematic analysis with interview data collected from GPs, RACF and MED service staff, and family members of residents.
Results
Most calls to MED (179/209) were recommended for care in the RACF and 30 for ambulance transport to hospital. There was a reduction in ED transfers from the six RACFs during the program compared to previous years and other RACFs. RACF staff reported that for 87 of the 209 calls to MED, they would have normally called the ambulance service directly if the MED afterhours service was not available to them. Qualitative themes included: Systems issues related to care in RACFs; Issues related to the MED Model of Care; Implementing the MED Program; and Experience of the MED program.
Conclusions
The afterhours telehealth model provided in-house care and reduced ambulance transfers, and GPs and RACF staff generally felt supported. The service was easy to use and fostered good communications with GPs and RACF staff. Some GPs preferred to provide their own care, commenting on the need for a good understanding of patient and family needs and of the local context. Other stakeholders suggested this model could be extended to palliative care settings and to normal business hours when GPs were unavailable. The reduced ambulance and hospital use suggested benefits to wider health systems, however policies and funding that remunerate GPs, support community-based care and provide additional staffing in RACFs are needed to sustain afterhours telehealth in RACFs. Use of the NASSS (non-adoption, abandonment, scale-up, spread, and sustainability) Framework provided a valuable explanatory lens for our analyses.
Therapeutic applications of topical injection
of hsa-miR-634 into canine spontaneous malignant
melanoma tumors
Authors: Yoshikawa Ryutaro , Inoue Jun , Iwasaki Ryota , Terauchi Mitsuhiko , fujii Yuji , Ohta Maya , Hasegawa Tomomi , Mizuno Rui , Mori Takashi , Inazawa Johji 
Published: January 2023

Abstract
Malignant melanoma (MM) is one of the most common tumors in both dogs and humans. As canine MM (CMM) and human MM (HMM) have similar clinical characteristics, CMM appears to be a good clinical model for HMM. We previously demonstrated that the introduction of a synthetic double-strand-microRNA-634 (miR-634) mimic triggered apoptotic cell death by directly targeting the genes associated with cytoprotective processes in various human cancer cell lines, including those of HMM. This study aimed to investigate the antitumor effects of topical administration of miR-634 on spontaneous CMMs to provide a basis for future applications of miR-634 formulations in HMM treatment. We found that miR-634 administration induced apoptosis in CMM cell lines in vitro via downregulation of Asct2, Nrf2, and survivin expression, similar to the mechanisms in HMM cell lines. Furthermore, intratumoral miR-634 administration induced antitumor effects in four of seven spontaneous CMM cases, with no adverse effects. Local administration of miR-634 to lung metastasis under ultrasound guidance induced tumor shrinkage. These results confirm the antitumor effect of topical administration of miR-634 in spontaneous CMM, a model for spontaneous HMM, thereby providing a novel treatment strategy for HMM.
2-Amino-4-arylthiophene-3-carbonitrile and Formamidine Acetate as Key Building Units for the Synthesis of 5-Arylthieno[2,3-d]pyrimidin-4- amines
Authors: Alizadeh-Bami Farzaneh , Mehrabi Hossein , Hosseini-pour Maryam 
Published: January 2023

Abstract
A novel series of thieno[2,3-d]pyrimidine analogues was designed and synthesized via three-step reactions. A novel condition has been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald method and in the last step to form thieno[2,3-d]pyrimidines by using formamidine acetate. The structure of these compounds was confirmed by IR, 1H-NMR, 13C-NMR, and CHN analysis.
Effect of Conbercept for macular edema secondary to branch retinal vein occlusion in different ethnic groups in Southeast Guizhou
Authors: Zhu Tongle , Wang Fen , Yang Chunman , Xu Xiaoying , Yang Zhumin , Yang Yanan , Mao Yujie , Liu Caiyu 
Published: January 2023

Abstract
Objective: To evaluate the clinical efficacy of Conbercept on macular edema secondary to branch retinal vein occlusion and to explore the relevant influencing factors.
Method: The clinical data of 94 patients (94 eyes) with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) in the Second Affiliated Hospital of Guizhou Medical University from January 2015 to September 2019 were collected. All patients received 3+PRN intravitreal injection of Conbercept. The best corrected visual acuity (BCVA), central macular thickness (CMT), ellipsoid zone and external membrane integrity were observed before treatment and 1, 3, 6 and 12 months after treatment.
Result：The constituent characteristics of different nationalities in this study are 38.30% (36 / 94) of Han nationality, 34.04% (32 / 94) of Miao nationality and 27.66% (26 / 94) of Dong nationality.The clinical baseline data (age, gender, preoperative BCVA, and CMT) of ME secondary to BRVO in different nationalities were not statistically significant. There was no significant difference in BCVA and CMT between Han, Miao and Dong nationalities at 1, 3, 6 and 12 months after operation. Patients’ BCVA of different nationalities at 1, 3, 6 and 12 months after operation was significantly higher than that before treatment (P < 0.05). Patients’ CMT of different nationalities decreased significantly after 1, 3, 6 and 12 months (P < 0.05). In the multiple regression analysis of this study, baseline CMT was not related to baseline BCVA (P > 0.05). Age, course of disease and integrity of the ellipsoid zone were related to baseline BCVA (P < 0.05). Baseline BCVA and baseline external membrane integrity were related to BCVA (P < 0.05).
Conclusion：In the treatment of ME secondary to BRVO, Conbercept shows time stability and broad-spectrum demographic characteristics, and it can be widely used in ethnic minority areas in Southeast Guizhou.
Exogenous epibrassinolide application improves essential oil biosynthesis and trichome development in peppermint via modulating growth and physicochemical processes
Authors: Parrey Zubair Ahmad , Shah Sajad Hussain , Mohammad Firoz , Siddiqui Manzer H. , Alamri Saud , Kalaji Hazem M. 
Published: January 2023

Abstract
Peppermint has gained a promising status due to the presence of a high proportion of bioactive compounds especially menthol. Due to its pharmacological efficacy, the demand for its plant-based bioactive compounds necessitates its cultivation worldwide. Brassinosteroids are polyhydroxylated sterol derivatives that regulate diverse processes and control many agronomic traits during plant growth and development. A factorial randomised pot experiment was performed in the net house to investigate the effect of 24-Epibrassinolide (EBL) on the growth, physiology, essential oil content, stomatal behaviour and trichome development of the three cultivars of peppermint. Four levels of foliage-applied EBL, viz. 0, 10− 5, 10− 6 and 10− 7 M were applied on the three cultivars of peppermint (Kukrail, Pranjal and Tushar). Among the different treatments of EBL on Kukrail, Tushar and Pranjal, the application of 10− 6 M increased shoot length by 38.84, 37.59 and 36.91%, root length by 36.73, 29.44 and 33.47%, respectively. Whereas chlorophyll content by 24.20, 22.48 and 23.32%, PN by 32.88, 32.61 and 33.61%, respectively. Further, EO content was enhanced by 32.72, 30.00 and 28.84%, EO yield per plant by 66.66, 77.77 and 73.33%, menthol yield per plant by 127.27, 110 and 118.18% compared with their respective control plants. The scanning electron microscopical analysis revealed increased trichome size and density whereas, the confocal laser scanning microscopical analysis revealed enhanced cellular viability in the treated plants as compared with the control. Moreover, the GC-MS analysis revealed the enhanced essential oil content particularly menthol in the treated plants over the control.