bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPAYA JANDA CERAI MATI DALAM MENJAGA KETAHANAN KELUARGA: STUDI DI JORONG KAYU GADIH KENAGARIAN TANJUNG GADANG KAPUPATEN SIJUNJUNG
Authors: Halim Syaflin , Syamsurizal Syamsurizal , Putri Meksi Andari , Prayoga Kevin 
Published: May 2023

Setiap orang dalam masyarakat pasti akan berusaha mengambil tindakan untuk melindungi diri atau menanggung situasi atau kondisi apapun yang mereka hadapi. Dalam hal ini tidak lupa warga masyarakat janda yang cerai mati di Jorong Kayu Gadih Kenagarian Tanjung Gadang Kabupaten Sijunjung berupaya untuk bertahan dalam situasi yang tidak menentu. Struktur sosial yang mengamanatkan janda cerai untuk meninggal dunia sendiri menjalankan tugas ibu dan ayah, termasuk mengasuh anak, menafkahi rumah, dan menyekolahkan anak. Karena kecenderungan mereka untuk menghidupi keluarga mereka secara finansial, orang tua sering berjuang untuk memenuhi kebutuhan mereka sendiri, meninggalkan para janda dan janda cerai untuk mencari solusi kreatif. Penelitian ini berusaha untuk memastikan bagaimana janda cerai meninggal untuk memenuhi kebutuhan finansial keluarganya di Jorong Kayu Gadang Kenagarian Tanjung Gadang Kabupaten Sijunjung. Teknik purposive yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif dan strategi untuk mengidentifikasi informan. Peneliti menggunakan observasi dan wawancara mendalam terfasilitasi dengan informan sebagai metode pengumpulan data primer mereka. Menurut temuan penelitian ini, janda cerai yang bekerja sebagai buruh harian lepas sebagai petani kebun dengan menyadap karet dalam menafkahi kebutuhan ekonomi keluarganya..
Kata Kunci: Janda, Cerai Mati, Ketahanan Ekonomi Keluarga
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETIL ASETAT DAUN TEKELAN (Chromolaena odorata (L.) R. King & H. Rob) PADA TIKUS PUTIH JANTAN (Rattus norvegicus)
Authors: Situngkir Ririn , Mambang D. Elysa Putri 
Published: May 2023

Tekelan (Chromolaena odorata (L.)R. King & H. Rob)merupakan salah satu tumbuhan yang termasuk famili Asteraceae.Kandungan kimia dari ekstrak etil asetat daun tekelan yaitu alkaloid, flavonoid, tanin, saponin, steroid/triterpenoid yang diduga dapat menyembuhkan radang atau inflamasi.Tujuan dari penelitian ini adalah untuk menguji aktivitas antiinflamasi dari ekstrak etil asetat daun tekelan pada tikus putih jantan. Metode penelitian ini dilakukan dengan cara maserasi. Uji aktivitas penyembuhan radang dari EEADT dilakukan terhadap tikus putih jantan yang diinduksi dengan karagenan 1 % secara intraplantar. Hewan uji digunakan 25 ekor dan dibagi 5 kelompok, yaitu kelompok kontrol negatif (Na.CMC 0,5 %), uji kontrol positif (Natrium diklofenak 25mg/KgBB), EEADT masing-masing dengan dosis 50mg/KgBB,100mg/KgBB, 200mg/KgBB kemudian diukur radang dengan menggunakan alat plestimometer dengan pengamatan adanya penurunan radang dilakukan setiap 60 menit selama 360 menit atau 6 jam. Di hitung persentase penurunan radang diperoleh dilakukan analisis statistik dengan uji ANOVA menggunakan SPSS (Statistical Program Service Solution). Hasil statistik menunjukkan kelompok hewan uji dengan pemberian EEADT pada dosis 50mg/KgBB, 100mg/KgBB, 200mg/KgBB berturut turut sembuh. Hasil ANOVA menunjukkan (P<0,05) berarti terdapat perbedaan setiap perlakuan. Dapat disimpulkan bahwa EEADT mempunyai aktivitas penyembuhan inflamasi tercepat tejadi pada kelompok hewan uji dosis 200mg/KgBB.
A reforma trabalhista como incentivo ao dumping social
Authors: Souto Bolzan Lucas 
Published: May 2023

O artigo trata das alterações advindas da reforma trabalhista (Lei n. 13.467/17) e seus possíveis impactos no fenômeno do dumping social. O problema de pesquisa do artigo é: as alterações no ordenamento jurídico brasileiro advindas da reforma trabalhista (Lei n. 13.467/17) incentivam o dumping social no Brasil? O estudo inicia pela conceituação do dumping social e finaliza com o estudo de alguns aspectos da reforma trabalhista ligados ao problema apresentado, são eles: o acesso à justiça e o benefício da justiça gratuita; os honorários advocatícios e periciais; o acordo extrajudicial (processo de jurisdição voluntária); a correção monetária e os juros; e por fim a aplicação do direito e a limitação do poder jurisprudencial dos tribunais trabalhistas. Dentre as conclusões tem-se que a legislação reformista de fato contribui para o crescimento do fenômeno do dumping social na medida em que apequena a justiça do trabalho e impede o acesso a ela.
Ortaokul Matematik Öğretmeni Adaylarının Sayıların Öğretiminde Kullandıkları Gerçek Hayat İlişkilendirmelerinin İncelenmesi
Authors: Ünlü Melihan 
Published: May 2023

Bu araştırmanın amacı, ortaokul matematik öğretmeni adaylarının sayıların öğretiminde kullandıkları gerçek hayat ilişkilendirmelerinin incelenmesidir. Bu amaçla, öğretmen adaylarının gerçek hayatla ilişkilendirmeyi nasıl yaptıkları, ilişkilendirme yaparken hangi bağlamları kullandıkları ve gerçek hayatla ilişkilendirme konusunda ne düşündükleri belirlenmiştir. Araştırmada nitel araştırma yöntemlerinden durum çalışması kullanılmıştır. Araştırmanın çalışma grubu bir devlet üniversitesinin ilköğretim matematik öğretmenliği programına devam eden öğretmen adaylarından oluşmaktadır. Veriler gerçek hayat ilişkilendirmelerine yönelik Gainsburg’un (2008) kodlar ve içerik analizi kullanılarak analiz edilmiştir. Araştırmanın bulgularına göre, öğretmen adayları genel olarak gerçek hayat ilişkilendirmelerinde sözel klasik problemleri ve alışveriş- ticaret bağlamlarını kullanmışlardır. Ayrıca öğretmen adaylarıyla yapılan görüşmeler sonucunda, öğretmen adaylarının sayılar konusunun gerçek hayatla ilişkilendirilerek öğretilmesi gerektiğini düşündükleri belirlenmiştir.
PROSEDUR HUKUM PEMBIMBINGAN KLIEN PEMASYARAKATAN
Authors: Agung Nugroho Muchamad Arif , . Solihah 
Published: May 2023

This research makes the general public understand about the legal procedures of mentoring for clients. The problem in this research is what is the legal procedure of mentoring for clients? This research focuses on the legal procedures, so it has advantages over previous research that focus more on the system. This research uses a qualitative approach and focuses on the type of normative legal research. The types of data are statutory regulations, legal books, scientific journals, and the results of interviews and observations. Data collection techniques are documentation, observation, and interviews. In the results and discussion, there is no detailed of the legal procedures of mentoring for clients but there is a Standard Operational Procedure. In the conclution, there are 3 stages of mentoring for clients, namely (a) Initial Stage; (b) Advanced Stage; and (c) Final Stage.
Key Words: Monitoring; Clients, Penitentiary
MENGUKUR IMUNITAS PEJABAT PELAKSANA PERPPU COVID-19 DENGAN ASAS EQUALITY BEFORE THE LAW
Authors: Pratama Agung Barok 
Published: May 2023

The immunity of officials implementing Perppu 1/2020 is in the public spotlight because it is not following “the principles of the rule of law and” injures the sense of justice in society because there are exceptions to legal “action. The principle of equality before the law” becomes a fundamental basis in viewing the position and position of every citizen. Therefore, it is necessary to measure the extent of impunity in the enforcement process for alleged violations of the law and its implications for the principle of Equality Before The Law. Based on the focus of the study, “the method used in this research is normative legal research and the statutory approach” is the basis for this writing. The paper concludes that Perppu 1/2020 does not necessarily provide absolute immunity to the implementing officials of the Perppu, but is limited (conditional) and the legal process is still carried out so as not to “violate the principles of the rule of law.
Keywords : Immunity, Official, Perppu
Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation
Authors: Abdullah Zainab , Ashraf Muhammad Umer , Barkat Kashif , Badshah Syed Faisal , Rehman Umaira , Razzaq Asma , Mahmood Asif , Ulhaq Farid , Chopra Hitesh , Rashid Summya , Valko Marian , Alomar Suliman , Kuca Kamil , Sharma Rohit 
Published: May 2023

Introduction: The objective of current project was to formulate a system for controlled delivery of Tramadol HCl (TRD), an opioid analgesic used in the treatment of moderate to severe pain.Methods: For this purpose, a pH responsive AvT-co-poly hydrogel network was formulated through free radical polymerization by incorporating natural polymers i.e., aloe vera gel and tamarind gum, monomer and crosslinker. Formulated hydrogels were loaded with Tramadol HCl (TRD) and evaluated for percent drug loading, sol-gel fraction, dynamic and equilibrium swelling, morphological characteristics, structural features and in-vitro release of Tramadol HCl.Results and Discussions: Hydrogels were proved to be pH sensitive as remarkable dynamic swelling response ranging within 2.94g/g-10.81g/g was noticed at pH 7.4 as compared to pH 1.2. Percent drug loading was in the range of 70.28%-90.64% for all formulations. Thermal stability and compatibility of hydrogel components were validated by DSC analysis and FTIR spectroscopy. Controlled release pattern of Tramadol HCl from the polymeric network was confirmed as maximum release of 92.22% was observed for over a period of 24 hours at pH 7.4. Moreover, oral toxicity studies were also conducted in rabbits to investigate the safety of hydrogels. No evidence of any toxicity, lesions and degeneration was reported, confirming the biocompatibility and safety of grafted system.
Molecular characterization of Smtdc-1 and Smddc-1 discloses roles as male-competence factors for the sexual maturation of Schistosoma mansoni females
Authors: Li Xuesong , Weth Oliver , Haeberlein Simone , Grevelding Christoph G. 
Published: May 2023

IntroductionSchistosomes are the only mammalian flatworms that have evolved separate sexes. A key question of schistosome research is the male-dependent sexual maturation of the female since a constant pairing contact with a male is required for the onset of gonad development in the female. Although this phenomenon is long known, only recently a first peptide-based pheromone of males was identified that contributes to the control of female sexual development. Beyond this, our understanding of the molecular principles inducing the substantial developmental changes in a paired female is still rudimentary.ObjectivesPrevious transcriptomic studies have consistently pointed to neuronal genes being differentially expressed and upregulated in paired males. These genes included Smp_135230 and Smp_171580, both annotated as aromatic-L-amino-acid decarboxylases (DOPA decarboxylases). Here, we characterized both genes and investigated their roles in male–female interaction of S. mansoni.Methodologies/findingsSequence analyses indicated that Smp_135230 represents an L-tyrosine decarboxylase (Smtdc-1), whereas Smp_171580 represents a DOPA decarboxylase (Smddc-1). By qRT-PCR, we confirmed the male-specific and pairing-dependent expression of both genes with a significant bias toward paired males. RNA-interference experiments showed a strong influence of each gene on gonad differentiation in paired females, which was enhanced by double knockdown. Accordingly, egg production was significantly reduced. By confocal laser scanning microscopy, a failure of oocyte maturation was found in paired knockdown females. Whole-mount in situ hybridization patterns exhibited the tissue-specific occurrence of both genes in particular cells at the ventral surface of the male, the gynecophoral canal, which represents the physical interface of both genders. These cells probably belong to the predicted neuronal cluster 2 of S. mansoni.ConclusionOur results suggest that Smtdc-1 and Smddc-2 are male-competence factors that are expressed in neuronal cells at the contact zone between the genders as a response of pairing to subsequently control processes of female sexual maturation.
Examining perceptions of a telemedicine network for pediatric emergency medicine: a mixed-methods pilot study
Authors: Mateus Lidia A. , Law Madelyn P. , Khowaja Asif Raza , Orlando Elaina , Pace Alexander , Roy Madan , Sulowski Christopher 
Published: May 2023

BackgroundUse of telemedicine for healthcare delivery in the emergency department can increase access to specialized care for pediatric patients without direct access to a children's hospital. Currently, telemedicine is underused in this setting.ObjectivesThis pilot research project aimed to evaluate the perceived effectiveness of a telemedicine program in delivering care to critically ill pediatric patients in the emergency department by exploring the experiences of parents/caregivers and physicians.MethodsSequential explanatory mixed methods were employed, in which quantitative methods of inquiry were followed by qualitative methods. Data were collected through a post-used survey for physicians, followed by semi-structured interviews with physicians and parents/guardians of children treated through the program. Descriptive statistics were used to analyze the survey data. Reflexive thematic analysis was used to analyze interview data.ResultsThe findings describe positive perceptions of telemedicine for emergency department pediatric care, as well as barriers and facilitators to its use. The research also discusses implications for practice and recommendations for overcoming barriers and supporting facilitators when implementing telemedicine programming.ConclusionThe findings suggest that a telemedicine program has utility and acceptance among parents/caregivers and physicians for the treatment of critically ill pediatric patients in the emergency department. Benefits recognized and valued by both parents/caregivers and physicians include rapid connection to sub-specialized care and enhanced communication between remote and local physicians. Sample size and response rate are key limitations of the study.
Nomogram prediction for cervical lymph node metastasis in multifocal papillary thyroid microcarcinoma
Authors: Li Wen-Hui , Yu Wei-Ying , Du Jia-Rui , Teng Deng-Ke , Lin Yuan-Qiang , Sui Guo-Qing , Wang Hui 
Published: May 2023

AimAccurate preoperative prediction of cervical lymph node metastasis (LNM) in patients with mPTMC provides a basis for surgical decision making and the extent of tumor resection. This study aimed to develop and validate an ultrasound radiomics nomogram for the preoperative assessment of LN status.MethodsA total of 450 patients pathologically diagnosed with mPTMC were enrolled, including 348 patients in the modeling group and 102 patients in the validation group. Univariate and multivariate logistic regression analyses were performed on the basic information, ultrasound characteristics, and American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) scores of the patients in the modeling group to identify independent risk factors for LNM in mPTMC and to construct a logistic regression equation and nomogram to predict the risk of LNM. The validation group data were used to evaluate the predictive performance of the nomogram.ResultsMale sex, age &lt;40 years, a single lesion with a maximum diameter &gt;0.5 cm, capsular invasion, a maximum ACR score &gt;9 points, and a total ACR score &gt;19 points were independent risk factors for the development of cervical LNM in mPTMC. Both the area under the curve (AUC) and concordance index (C-index) of the prediction model constructed from the above six factors were 0.838. The calibration curve of the nomogram was close to the ideal diagonal line. Furthermore, decision curve analysis (DCA) demonstrated a significantly greater net benefit of the model. The external validation demonstrated the reliability of the prediction nomogram.ConclusionsThe presented radiomics nomogram, which is based on ACR TI-RADS scores, shows favorable predictive value for the preoperative assessment of LNs in patients with mPTMC. These findings may provide a basis for surgical decision making and the extent of tumor resection.
Soil fertility and landscape surrounding former arable fields drive the ecological resilience of Mediterranean dry grassland plant communities
Authors: Jaunatre Renaud , Buisson Elise , Leborgne Elsa , Dutoit Thierry 
Published: May 2023

IntroductionSemi-natural dry grasslands are among the species-richest and most diverse habitats in Europe especially in the Mediterranean Basin. They evolved with long-term severe environmental constraints, either biotic (e.g., grazing or mowing) or abiotic (e.g., dryness or oligotrophy). Their recovery after sever anthropogenic disturbance, such as cultivation is often very slow and incomplete. A deeper understanding of the processes driving the recovery would be of great benefit to better restore or conserve these grasslands. We used the filter model as a framework to assess the relative importance of dispersion, abiotic and biotic filters as drivers of this recovery.MethodsWe studied the medium-term dynamics of 37 Mediterranean dry grassland plant communities after an episode of cultivation in the plain of La Crau (Southern France) by two census: after 25 years of abandonment, and revisited 10 years later (35 years of abandonment). Our aims were to characterize the temporal medium-term dynamics of these communities, to measure their taxonomic resilience and to identify the drivers. We performed structural equation modeling to measure the importance of the various drivers, with cover of remnant dry grasslands surrounding each studied community as a proxy for the dispersion filter, soil pH and phosphorus content as proxies for the abiotic filter and cover of the most dominant species as a proxy for the biotic filter.Results and DiscussionOur results show that former arable field vegetation do not recover after more than 40 years. The three filters drive the recovery of dry grassland vegetation: former arable fields that have lower phosphorus content (abiotic filter) have a lower cover of dominant species (biotic filter), a higher species richness and a higher similarity with remnant dry grassland plant communities, especially if the former arable fields are surrounded by remnant dry grasslands (dispersion filter).
Facilitating systems-level analyses of all-cause and Covid-mediated sepsis through SeptiSearch, a manually-curated compendium of dysregulated gene sets
Authors: Baghela Arjun S. , Tam Jasmine , Blimkie Travis M. , Dhillon Bhavjinder K. , Hancock Robert E.W. 
Published: May 2023

BackgroundSepsis is a dysfunctional host response to infection. The syndrome leads to millions of deaths annually (19.7% of all deaths in 2017) and is the cause of most deaths from severe Covid infections. High throughput sequencing or ‘omics’ experiments in molecular and clinical sepsis research have been widely utilized to identify new diagnostics and therapies. Transcriptomics, quantifying gene expression, has dominated these studies, due to the efficiency of measuring gene expression in tissues and the technical accuracy of technologies like RNA-Seq.ObjectiveMost of these studies seek to uncover novel mechanistic insights into sepsis pathogenesis and diagnostic gene signatures by identifying genes differentially expressed between two or more relevant conditions. However, little effort has been made, to date, to aggregate this knowledge from such studies. In this study we sought to build a compendium of previously described gene sets that combines knowledge gained from sepsis-associated studies. This would enable the identification of genes most associated with sepsis pathogenesis, and the description of the molecular pathways commonly associated with sepsis.MethodsPubMed was searched for studies using transcriptomics to characterize acute infection/sepsis and severe sepsis (i.e., sepsis combined with organ failure). Several studies were identified that used transcriptomics to identify differentially expressed (DE) genes, predictive/prognostic signatures, and underlying molecular responses and pathways. The molecules included in each gene set were collected, in addition to the relevant study metadata (e.g., patient groups used for comparison, sample collection time point, tissue type, etc.).ResultsAfter performing extensive literature curation of 74 sepsis-related publications involving transcriptomics, 103 unique gene sets (comprising 20,899 unique genes) from thousands of patients were collated together with associated metadata. Frequently described genes included in gene sets as well as the molecular mechanisms they were involved in were identified. These mechanisms included neutrophil degranulation, generation of second messenger molecules, IL-4 and -13 signaling, and IL-10 signaling among many others. The database, which we named SeptiSearch, is made available in a web application created using the Shiny framework in R, (available at https://septisearch.ca).ConclusionsSeptiSearch provides members of the sepsis community the bioinformatic tools needed to leverage and explore the gene sets contained in the database. This will allow the gene sets to be further scrutinized and analyzed for their enrichment in user-submitted gene expression data and used for validation of in-house gene sets/signatures.
Tocilizumab versus anakinra in COVID-19: results from propensity score matching
Authors: Arcani Robin , Correard Florian , Suchon Pierre , Kaplanski Gilles , Jean Rodolphe , Cauchois Raphael , Leprince Marine , Arcani Vincent , Seguier Julie , De Sainte Marie Benjamin , Andre Baptiste , Koubi Marie , Rossi Pascal , Gayet Stéphane , Gobin Nirvina , Garrido Victoria , Weiland Joris , Jouve Elisabeth , Couderc Anne-Laure , Villani Patrick , Daumas Aurélie 
Published: May 2023

BackgroundTocilizumab and anakinra are anti-interleukin drugs to treat severe coronavirus disease 2019 (COVID-19) refractory to corticosteroids. However, no studies compared the efficacy of tocilizumab versus anakinra to guide the choice of the therapy in clinical practice. We aimed to compare the outcomes of COVID-19 patients treated with tocilizumab or anakinra.MethodsOur retrospective study was conducted in three French university hospitals between February 2021 and February 2022 and included all the consecutive hospitalized patients with a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection assessed by RT-PCR who were treated with tocilizumab or anakinra. A propensity score matching was performed to minimize confounding effects due to the non-random allocation.ResultsAmong 235 patients (mean age, 72 years; 60.9% of male patients), the 28-day mortality (29.4% vs. 31.2%, p = 0.76), the in-hospital mortality (31.7% vs. 33.0%, p = 0.83), the high-flow oxygen requirement (17.5% vs. 18.3%, p = 0.86), the intensive care unit admission rate (30.8% vs. 22.2%, p = 0.30), and the mechanical ventilation rate (15.4% vs. 11.1%, p = 0.50) were similar in patients receiving tocilizumab and those receiving anakinra. After propensity score matching, the 28-day mortality (29.1% vs. 30.4%, p = 1) and the rate of high-flow oxygen requirement (10.1% vs. 21.5%, p = 0.081) did not differ between patients receiving tocilizumab or anakinra. Secondary infection rates were similar between the tocilizumab and anakinra groups (6.3% vs. 9.2%, p = 0.44).ConclusionOur study showed comparable efficacy and safety profiles of tocilizumab and anakinra to treat severe COVID-19.