bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variants influenced the risk of bleeding and pharmacodynamics of rivaroxaban in patients with nonvalvular atrial fibrillation: A multicentre prospective cohort study
Authors: Xiang Qian , Wang Zhe , Mu Guangyan , Xie Qiufen , Liu Zhiyan , Zhou Shuang , Zhang Hanxu , Wang Zining , Jiang Jie , Hu Kun , Zhang Yatong , Zhao Zinan , Yuan Dongdong , Guo Liping , Wu Tingting , Zhang Jinhua , Wang Na , Xiang Jing , Gu Zhichun , Sun Jianjun , Cui Yimin 
Published: May 2023

AbstractIntroductionIndividual variability of rivaroxaban was observed in clinical application. This study aimed to identify genetic variants associated with the variability of pharmacodynamics and bleeding risk of rivaroxbaban in patients with nonvalvular atrial fibrillation (NVAF).Materials and MethodsFrom June 2017, and July 2019, this study enrolled 257 patients with NVAF receiving rivaroxaban. Pharmacodynamics was assessed by determining anti‐Factor Xa (anti‐FXa) level 3 h after rivaroxaban administration as peak concentration. Whole‐exome sequencing was performed to detected single nucleotide polymorphisms (SNPs). This study was registered (NCT03161496).ResultsThe bleeding events within 12 months were significantly related to the peak anti‐FXa level (p = .027). SUSD3 rs76292544 was associated with 12‐month bleeding events (odds ratio [OR]: 4.20, 95% confidence interval [CI]: 2.17–8.14, p = 6.43×10−5). Five SNPs including NCMAP rs4553122 (p = 2.29×10−5), PRF1 rs885821 (p = 7.02×10−5), PRKAG2 rs12703159 (p = 7.97×10−5), PRKAG2 rs13224758 (p = 8.70×10−5), and POU2F3 rs2298579 (p = 8.24×10−5) were associated with peak anti‐FXa level. Genetic variants of 52 SNPs from 36 genes including GOT2 rs14221 and MMP13 rs640198 were potentially related to 12‐month bleeding events caused by rivaroxaban's efficacy.ConclusionsPeak anti‐FXa level was associated with risk of bleeding events in patients with NVAF receiving rivaroxaban. SUSD3 rs76292544 was suggestively associated with 12‐month bleeding events and five SNPs (NCMAP rs4553122, PRF1 rs885821, PRKAG2 rs12703159, rs13224758 and POU2F3 rs2298579) were suggestively associated with peak anti‐FXa level.
Opportunistic consumption of coral spawn by the ruby brittle star (Ophioderma rubicundum)
Authors: Williamson Olivia M. , Mustard Alexander T. , Bright Allan J. , Williams Dana E. , Ladd Mark C. , Baker Andrew C. 
Published: May 2023

AbstractMany reef invertebrates reproduce through simultaneous broadcast spawning, with an apparent advantage of overwhelming potential predators and maximizing propagule survival. Although reef fish have been observed to consume coral gamete bundles during spawning events, there are few records of such predation by benthic invertebrates. Here, we document several instances of the ruby brittle star, Ophioderma rubicundum, capturing and consuming egg‐sperm bundles of the mountainous star coral, Orbicella faveolata, and the symmetrical brain coral, Pseudodiploria strigosa, during spawning events in the Cayman Islands in 2012 and the Florida Keys in 2022. These observations are widely separated in space and time (>600 km, 10 years), suggesting that this behavior may be prevalent on western Atlantic reefs. Since O. rubicundum spawns on the same or subsequent nights as these coral species, we hypothesize that this opportunistic feeding behavior takes advantage of lipid‐rich coral gamete bundles to recover energy reserves expended by the brittle star during gametogenesis. The consumption of coral gametes by adult brittle stars suggests an underexplored trophic link between reef invertebrates and also provides evidence that ophiuroid–coral symbioses may oscillate between commensalism and parasitism depending on the ontogeny and reproductive status of both animals. Our observations provide insights into the nuanced, dynamic associations between coral reef invertebrates and may have implications for coral reproductive success and resilience.
Assessing risk for butterflies in the context of climate change, demographic uncertainty, and heterogeneous data sources
Authors: Forister Matthew L. , Grames Eliza M. , Halsch Christopher A. , Burls Kevin J. , Carroll Cas F. , Bell Katherine L. , Jahner Joshua P. , Bradford Taylor A. , Zhang Jing , Cong Qian , Grishin Nick V. , Glassberg Jeffrey , Shapiro Arthur M. , Riecke Thomas V. 
Published: May 2023

AbstractOngoing declines in insect populations have led to substantial concern and calls for conservation action. However, even for relatively well studied groups, like butterflies, information relevant to species‐specific status and risk is scattered across field guides, the scientific literature, and agency reports. Consequently, attention and resources have been spent on a minuscule fraction of insect diversity, including a few well studied butterflies. Here we bring together heterogeneous sources of information for 396 butterfly species to provide the first regional assessment of butterflies for the 11 western US states. For 184 species, we use monitoring data to characterize historical and projected trends in population abundance. For another 212 species (for which monitoring data are not available, but other types of information can be collected), we use exposure to climate change, development, geographic range, number of host plants, and other factors to rank species for conservation concern. A phylogenetic signal is apparent, with concentrations of declining and at‐risk species in the families Lycaenidae and Hesperiidae. A geographic bias exists in that many species that lack monitoring data occur in the more southern states where we expect that impacts of warming and drying trends will be most severe. Legal protection is rare among the taxa with the highest risk values: of the top 100 species, one is listed as threatened under the US Endangered Species Act and one is a candidate for listing. Among the many taxa not currently protected, we highlight a short list of species in decline, including Vanessa annabella, Thorybes mexicanus, Euchloe ausonides, and Pholisora catullus. Notably, many of these species have broad geographic ranges, which perhaps highlights a new era of insect conservation in which small or fragmented ranges will not be the only red flags that attract conservation attention.
Persistently active interferon‐γ pathway and expansion of T‐bet+ B cells in a subset of patients with childhood‐onset systemic lupus erythematosus
Authors: Moneta Gian Marco , Bracaglia Claudia , Caiello Ivan , Farroni Chiara , Pires Marafon Denise , Carlomagno Raffella , Hiraki Linda , Vivarelli Marina , Gianviti Alessandra , Carbogno Simone , Ferlin Walter , de Min Cristina , Silverman Earl , Carsetti Rita , De Benedetti Fabrizio , Marasco Emiliano 
Published: May 2023

AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease causing significant morbidity and mortality, despite important improvements in its management in the last decades. The objective of this work is to investigate the role of IFN‐γ in the pathogenesis of childhood‐onset systemic lupus erythematosus (cSLE), evaluating the crosstalk between IFN‐α and IFN‐γ and the expression of T‐bet, a transcription factor induced by IFN‐γ, in B cells of patients with cSLE. Expression levels of both IFN‐α and IFN‐γ‐induced genes were upregulated in patients with cSLE. We found increased serum levels of CXCL9 and CXCL10 in patients with cSLE. Type I IFN score decreased with initiation of immunosuppressive treatment; conversely, type II IFN score and levels of CXCL9 were not significantly affected by immunosuppressive treatment. Type II IFN score and CXCL9 were significantly higher in patients with lupus nephritis. We observed the expansion of a population of naïve B cells expressing T‐bet in a cluster of patients with cSLE. IFN‐γ, but not IFN‐α, induced the expression of T‐bet in B cells. Our data suggest that IFN‐γ is hyperactive in cSLE, especially in patients with lupus nephritis, and it is not modulated by therapy. Our data reinforce the potential of IFN‐γ as a therapeutic target in SLE.
Lab‐based electrochemical X‐ray photoelectron spectroscopy for in‐situ probing of redox processes at the electrified solid/liquid interface
Authors: Griesser Christoph , Winkler Daniel , Moser Toni , Haug Leander , Thaler Marco , Portenkirchner Engelbert , Klötzer Bernhard , Diaz‐Coello Sergio , Pastor Elena , Kunze‐Liebhäuser Julia 
Published: May 2023

AbstractA profound understanding of the solid/liquid interface is central in electrochemistry and electrocatalysis, as the interfacial properties ultimately determine the electro‐reactivity of a system. Although numerous electrochemical methods exist to characterize this interface under operating conditions, tools for the in‐situ observation of the surface chemistry, that is, chemical composition and oxidation state, are still scarce, and currently exclusively available at synchrotron facilities. Here, we demonstrate the ability of laboratory‐based near‐ambient pressure X‐ray photoelectron spectroscopy to track changes in oxidation states in‐situ with respect to the applied potential. In this proof‐of‐principle study with polycrystalline gold (Au) as the best‐studied electrochemical standard, we show that during the oxygen evolution reaction (OER), at high OER overpotentials, Au3+ governs the interfacial chemistry, while, at lower overpotentials, Au+ dominates.
A hybrid combination of EV charging stations with renewable energy sources for powering a residential community. A techno‐economic perspective
Authors: Mas’ud Abdullahi Abubakar 
Published: May 2023

AbstractIn this study, the performance of PV/wind/Diesel/battery schemes to satisfy the electrical load requirements of a residential community in five Nigerian cities: Sokoto, Katsina, Dutse, Jos, Gusau, and Zaria, have been techno‐economically evaluated. Two cases were considered: First, the hybrid system is designed to satisfy a residential community's load demand. Second, the system is optimized to satisfy both the requirements of electrical vehicles (EV) and the residential community. All simulations were carried out in MATLAB and validated by HOMER. For better utilization of energy, EV charging was carried out during periods of significant excess energy. The daily travel distance for EVs was set between 25 and 65 km. Sokoto and Gusau have the lowest LCOE (0.312) and NPC ($1.71 M) for a hybrid scheme without an EV battery charging, while Zaria has the highest (0.325 and $1.78 M). On the other hand, Sokoto and Gusau have the lowest LCOE (0.306) and NPC ($1.81 M) for a hybrid scheme with EV battery charging, whereas Zaria has the highest (0.32 and $1.89 M). Furthermore, as the EV travel distance increases, NPC rises, while the LCOE is highly sensitive to seasonal power requirements. The system has successfully utilized excess energy without compromising its financial viability. The novelty of the work presented in this paper is that for the first time a hybrid renewable energy system incorporating EV charging has been designed for various locations in Nigeria, which may aid policymakers in determining suitable locations for these schemes.
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response
Authors: Chen Yanan , Quan Songhua , Patil Vaibhav , Kunjamma Rejani B. , Tokars Haley M. , Leisten Eric D. , Joy Godwin , Wills Samantha , Chan Jonah R. , Wong Yvette C. , Popko Brian 
Published: May 2023

Abstractcentral nervous system (CNS) inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging the ISR protects remyelinating oligodendrocytes and promotes remyelination in the presence of inflammation. However, the exact mechanisms through which this occurs remain unknown. Here, we investigated whether the ISR modulator Sephin1 in combination with the oligodendrocyte differentiation enhancing reagent bazedoxifene (BZA) is able to accelerate remyelination under inflammation, and the underlying mechanisms mediating this pathway. We find that the combined treatment of Sephin1 and BZA is sufficient to accelerate early‐stage remyelination in mice with ectopic IFN‐γ expression in the CNS. IFN‐γ, which is a critical inflammatory cytokine in multiple sclerosis (MS), inhibits oligodendrocyte precursor cell (OPC) differentiation in culture and triggers a mild ISR. Mechanistically, we further show that BZA promotes OPC differentiation in the presence of IFN‐γ, while Sephin1 enhances the IFN‐γ‐induced ISR by reducing protein synthesis and increasing RNA stress granule formation in differentiating oligodendrocytes. Finally, pharmacological suppression of the ISR blocks stress granule formation in vitro and partially lessens the beneficial effect of Sephin1 on disease progression in a mouse model of MS, experimental autoimmune encephalitis (EAE). Overall, our findings uncover distinct mechanisms of action of BZA and Sephin1 on oligodendrocyte lineage cells under inflammatory stress, suggesting that a combination therapy may effectively promote restoring neuronal function in MS patients.
Efficacy of telemedicine interventions for depression and anxiety in older people: A systematic review and meta‐analysis
Authors: de Oliveira Paola Bell Felix , Dornelles Thayane Martins , Gosmann Natan Pereira , Camozzato Analuiza 
Published: May 2023

AbstractObjectivesAnxiety and depression are prevalent in the elderly and lead to loss of functionality and increased mortality. Although the use of antidepressants and face‐to‐face psychotherapies are indicated, the current context of telemedicine provides an alternative, with the advantage of facilitating access to care. The study aimed to evaluate the efficacy of telemedicine interventions to reduce anxiety and depression in the elderly through a systematic review with meta‐analysis.MethodsThe systematic review, through a search in 7 databases, included studies that evaluated the use of telemedicine interventions for depressive or anxious symptoms in the elderly, compared with usual care or waiting list or with another telemedicine intervention. Quantitative assessment was performed through meta‐analysis.ResultsA total of 31 articles identified in the search met the eligibility criteria and four were included for meta‐analysis. Studies showed that telemedicine interventions are feasible and several studies demonstrated significant improvement in depressive or anxiety symptoms. Four studies evaluated the efficacy of internet‐delivered cognitive behavioral therapy for depression and anxiety in older adults, compared with a waitlist, and found pooled effect sizes of −1.20 (95% CI −1.60 to −0.81) and −1.14 (95% CI −1.56 to −0.72), respectively, with low heterogeneity.ConclusionsTelemedicine interventions can be an alternative for the treatment of mood and anxiety symptoms in the elderly. However, more studies are needed to prove their clinical effectiveness, especially in countries with lower incomes and diverse culture and education.
Nomograms incorporating primary tumor response at mid‐radiotherapy to predict survival in locoregionally advanced nasopharyngeal carcinoma
Authors: Liu Xixi , Huang Jing , Qin You , Zhang Zhanjie , Wu Bian , Yang Kunyu 
Published: May 2023

AbstractBackgroundA nomogram that incorporates tumor response at mid‐radiotherapy (mid‐RT) to predict the prognosis of locoregionally advanced nasopharyngeal carcinoma (LA‐NPC) has not been established.MethodsThis study retrospectively reviewed 583 patients with LA‐NPC who underwent magnetic resonance imaging scans at mid‐RT (the fourth week of RT) between 2015 and 2019.ResultsPrimary tumor (PT) response at mid‐RT was found to predict disease‐free survival (DFS) and overall survival (OS). Independent factors from multivariable analysis to predict DFS and OS were assembled into nomograms with (nomograms Amid‐RT and Bmid‐RT) or without (nomograms Abaseline and Bbaseline) PT response. Internal validation revealed good performance of these nomograms in discrimination: C‐statistics = 0.761 for nomogram Amid‐RT and 0.809 for nomogram Bmid‐RT, which showed better discrimination performance than (C‐statistics: 0.755) nomogram Abaseline and (C‐statistics: 0.798) nomogram Bbaseline (Z‐statistic = 2.476, p < 0.05; Z‐statistic = 1.971, p < 0.05).ConclusionThe nomograms based on PT response at mid‐RT showed favorable predictive accuracy for DFS and OS in patients with LA‐NPC.
Value‐based public health: Moving beyond value‐based health care to support a wellbeing economy
Authors: Raymond Kate , Haddock Rebecca , Nathan Sally , Harrison Reema , Meyer Lois 
Published: May 2023

AbstractWhile value‐based health care (VBHC) is transforming Australia's health system, with its focus on patient‐centred care and outcomes, it cannot transform Australia's health without policy action to address the social determinants of health. Australia is moving towards a wellbeing economy, but governments have not been explicit in the methods by which the health system will contribute to the development of a wellbeing economy at a macro level. It is also unclear how governments will ensure that approaches to valuing wellbeing will complement current health care innovations in defining and evaluating value in relation to health outcomes. To address this gap, we present a value‐based public health (VBPH) framework to conceptualise a health‐informed model to expand current thinking about defining, delivering and evaluating the value of population health and wellbeing. The framework provides a critical and innovative approach beyond VBHC for improving population health and wellbeing outcomes, in alignment with principles and measures being put forth in early examples of governments using wellbeing economy policies. In VBPH, the focus is on ensuring value in interventions to improve population outcomes. VBPH offers an approach for joined‐up policy across government, using Health in All Policies for multi‐sector public health interventions in response to population needs, across full cycles of policy development, implementation and evaluation. It promotes social return on investment methods to measure outcomes that matter to diverse stakeholders within and across communities. VBPH also requires cost estimation from a whole of government perspective, across complete cycles and stages of policy.
Global increased cesarean section rates and public health implications: A call to action
Authors: Angolile Cornel M. , Max Baraka L. , Mushemba Justice , Mashauri Harold L. 
Published: May 2023

AbstractOver the years; global caesarian section (CS) rates have significantly increased from around 7% in 1990 to 21% today surpassing the ideal acceptable CS rate which is around 10%–15% according to the WHO. However, currently, not all CS are done for medical reasons with rapidly increasing rate of nonmedically indicated CS and the so‐called “caesarian on maternal request.” These trends are projected to continue increasing over this current decade where both unmet needs and overuse are expected to coexist with the projected global rate of 29% by 2030. CS reduces both maternal and neonatal morbidity and mortality significantly when it is done under proper indications while at the same time, it can be of harm to the mother and the child when performed contrary. The later exposes both the mother and the baby to a number of unnecessary short and long‐term complications and increase the chances of developing different noncommunicable diseases and immune‐related conditions among babies later in life. The implications of lowering SC rate will ultimately lower healthcare expenditures. This challenge can be addressed by several ways including provision of intensive public health education regarding public health implications of increased CS rate. Assisted vaginal delivery approaches like the use of vacuum and forceps and other methods should be considered and encouraged during delivery as long as their indications for implementation are met. Conducting frequent external review and audits to the health facilities and providing feedback regarding the rates of CS deliveries can help to keep in check the rising CS trends as well as identifying the settings with unmet surgical needs. Moreover, the public especially expectant mothers during clinic visits and clinicians should be educated and be informed on the WHO recommendations on nonclinical interventions towards reduction of unnecessary CS procedures.
Innovative approaches for enhancing English learning using fuzzy logic‐based intelligence assistant in the cloud platform
Authors: Yang Shengbo , Hu Yue , Chen Dong 
Published: May 2023

AbstractTraditional English online learning pattern suffers from many challenges which include slow response time, and poor‐quality for experiences, due to the remote distance of cloud servers. To solve these problems, this paper proposes an innovative approach which can help to optimize the English learning process by using the fuzzy logic idea based on the cloud platform. On one hand, the fuzzy logic is used to create an intelligent English learning model. On the other hand, using this model, we design a system in which the learning process is carried out efficiently. The experimental results demonstrate that this proposed work can gain students' preferences intelligently and improve their English learning scores effectively.
Novel KCNC2 variant associated with developmental and epileptic encephalopathy
Authors: Huo Liang , Wu Qiong , Yang Fan , Liu Xueyan , Yang Zuozhen , Wang Hua 
Published: May 2023

AbstractThe KCNC2 gene encodes Kv3.2, which is a member of the voltage‐gated potassium channel subfamily. It is crucial for the generation of fast‐spiking properties in cortical GABAergic interneurons. Recently, KCNC2 variations were found to be associated with epileptic encephalopathy in unrelated individuals. Here, we report a Chinese patient with developmental and epileptic encephalopathy (DEE) and motor development delay. Whole‐exome sequencing (WES) revealed a novel heterozygous variant in the KCNC2 gene NM_139137.4:c.1163T>C (p.Phe388Ser), and subsequent Sanger sequencing showed that it was a de novo mutation. We identified the KCNC2 likely pathogenic variant in a DEE patient by reanalysis of WES data in a Chinese family. Our study enriched the variation spectrum of the KCNC2 gene and promoted the application of WES technology and data reanalysis in the diagnosis of epilepsy.
Formal [4+1] annulations of salicylaldehydes with 3‐chlorooxindoles for diastereoselective construction of dihydrobenzofuranspirooxindoles by solvent‐free grinding
Authors: Li Yue , Wang Feng , Ning Rui , Kong Dulin , Wu Mingshu 
Published: May 2023

AbstractA highly diastereoselective solvent‐free grinding approach for the construction of dihydrobenzofuranspirooxindole derivatives through a formal [4+1] annulations of α‐chlorooxindoles with salicylaldehydes in the presence of Brønsted base is reported. This transformation proceeds by Darzens‐type epoxidation to give trans‐form spiro‐epoxyoxindoles, followed by the nucleophilic ring‐opening/an intramolecular cyclization, providing cis‐form dihydrobenzofuran frameworks.