bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEARIFAN LOKAL BUDAYA SUKU SAKAI TERHADAP SUMBER DAYA PERAIRAN DI KABUPATEN BENGKALIS
Authors: Putra Setia , Effendi Erdianto 
Published: January 2023

AbstrakMasyarakat Suku Sakai menangkap ikan di sungai dengan menombak dan mengail, serta menangkap udang dengan menggunakan tangguk. Di rawa-rawa atau di sungai-sungai kecil mereka menangkap ikan dengan menggunakan lukah dan jaring. Mereka memasang lukah dari jaring pada sore hari menjelang malam dan pada pagi hari dapat dilihat hasil tangkapannya. Ada larangan menangkap ikan dengan putas, pukat, sentrum dan racun bisa didenda adat berupa uang adat yang disepakati Pengurus Bathin (Kepala, Manti, Mangku). Dilarang menebang hutan dekat sungai dan danau, bila dilakukan maka didenda adat untuk memulihkan kerusakan dan disuruh menanam pohon 7 kali lebih banyak.Kata Kunci: kearifan lokal, perairan, Sakai AbstractThe Sakai tribe catches fish in the river by using the spear and hook, and using tangguk for shrimp. In swamps or small rivers they used a fish trap and netting to catch the fish. They put on the fish trap nets on the afternoon or before the night and they take the catch out in the morning. There is a ban on fishing with putas, gillnets, centrum and toxins and it can be fined by indigenous customary pecuniary who agreed by Bathin Board (Chief, Manti, Mangku). It is forbidden to cut down the forests near the rivers and the lakes, and the indigenous fined to recover the damage is to plant the tree seven times more.Keywords : local wisdom, water, Sakai
Potential Enhancement in The Nutritional Value of Local Agro-Waste Through Cultivation of Pink Oyster Mushroom (Pleurotus djamor)
Authors: Hutabarat Amelia Lulu Rosalin , Lestari Wenni Meika , Kuswoyo Anton , Ali Abdul Muta , Sari I. 
Published: January 2023

The present study aimed to examine the effect of locally available agro-industrial wastes on the growth and productivity of pink oyster mushrooms (Pleurotus djamor) and the potential use of substrates as animal feeding based on its compositional change following mushroom growth. A total of three substrate formulations labeled OPF (80% oil palm frond), CS (80% corn straw), and OPFCS (40% oil palm frond + 40% corn straw) were prepared. Aside from the earliest mycelium completion, pinhead formation, and fruiting bodies maturation, CS and OPFCS exhibit the best total yield, dry weight, and biological Efficiency. On the contrary, P. djamor grown in OPF resulted in the minimum in most of the parameters measured. Therefore, CS, single and in combination with OPF could be utilized as an alternative growing media for the cultivation of P. djamor. The analysis of chemical compositions showed that the growth of P. djamor significantly reduced the crude fiber (CF) and increased the crude protein (CP) content of the mycelium-treated substrate. In contrast, THE CP content of the spent is unchanged or relatively lower than that of the initial substrate. It can be concluded that compared to the spent, mycelium-treated substrate had higher values of being used for animal feeding.
Exploring audit quality at the Inland Revenue Board Malaysia
Authors: Zainal Zuriahati , Saad Natrah , Zainol Arrifin Zaimah 
Published: January 2023

Audit quality at the Inland Revenue Board Malaysia (IRBM) is a crucial element in the audit process to ensure no violation of tax reporting by the taxpayers. Hence, it is important to understand whether tax auditors perceive audit quality equally. Furthermore, recognizing the level of audit quality is also important to assist the tax authority in strategizing their efforts. This triggers researchers to embark on this exploratory study through document review and interviews. Data gathered were analysed using descriptive and thematic analysis. Results indicate that there is different perception of audit quality among tax officers, namely competency to detect the amount of audit settlement, audit settlement within the time frame and the achievement of the given key performance indicators (KPIs). The findings further indicate that the level of audit quality is quite alarming particularly with reference to the number of aging cases. The findings from this study provide an insight to the IRBM in their effort to streamline the direction of the tax auditors in improving audit quality.
Analisis Debit Banjir Rencana Daerah Tangkapan Air Waduk Tugu Menggunakan HEC-HMS
Authors: Rasyid Anas Zulfikar , Suharyanto Suharyanto , Kodoatie Robert Johanes , Satriyawan Yogi Pandhu 
Published: January 2023

Over the course construction of Tugu Reservoir, it is proposed to build a spillway gate to increase its performance as a flood control infrastructure. The construction planning of spillway gate requires a calculation of design flood discharge for Tugu Reservoir Catchment Area. The latest calculation was carried out during its construction planning in 2010. Therefore, it is necessary to evaluate and recalculate the design flood discharge using the latest data. This study aims to model design flood discharge of Tugu Reservoir Catchment Area using HEC-HMS software. This software is able to simulate rainfall-runoff modeling in a catchment area. Based on field conditions, Tugu Reservoir catchment has parameters, curve number value of 79, impervious value of 5%, and a lag time of 4.81 minutes. The result of the HEC-HMS modeling shows that the design flood discharge of Tugu Reservoir for Q100 is 369,30 m3/s; Q1000 is 656,70 m3/s; and QPMF is 995.30 m3/s. Based on the test using Creager Graph, the design flood discharge for Tugu Reservoir is still in the reasonable category with C value below 100. The result of the HEC-HMS modeling is not much different from the calculation result of Tugu Reservoir Construction Planning in 2010.
Possibilities of aggressive oncosurgery in treatment of IIA–IIIB stages of cervical cancer
Authors: Khakimov G. A. , Tashmetov M. N. , Khakimova G. G. , Musurmonov K. U. , Khakimova S. G. 
Published: January 2023

Introduction. Arming gynecological oncology with modern chemotherapy schemes, elements of aggressive oncosurgery, it is possible to achieve an increase in the number of cured patients with locally advanced forms of cervical cancer (CC), providing an improvement in the immediate and long-term results of treatment. The proposed method of surgical treatment is the method of choice for the surgical treatment of patients with locally advanced forms of cervical cancer (stages IIA–IIIB).Purpose of the study. Introduction into clinical practice of the method of surgical treatment of IIA–IIIB stages of cervical cancer.Material and methods. Long-term results of treatment of 155 patients with morphologically verified stage IIA–IIIB cervical cancer were studied. The patients underwent neoadjuvant chemotherapy (NACT) (n = 110) and chemoradiotherapy (CRT) (n = 45). When resectability was achieved, the patients underwent surgical treatment using a new technique. Overall survival (OS) and progression-free survival (PFS) outcomes were assessed.Results. In the period from 2017 to 2020, 155 patients with stage IIA–IIIB cervical cancer after NACT (n = 110) and CRT (n = 45) underwent combinedextended extirpation of the uterus with appendages according to our patented method. The most frequent postoperative complications were urination disorders in 106 (67 [60.9%] and 19 [42.2%]) patients, lymphatic cysts in 30 (20 [18.2%] and 10 [22.2%]) patients and vesicovaginal fistula in 7 patients (5 [4.6%] and 2 [4.4%]), respectively. According to the results of a pathomorphological study, the most frequent tumor response to NACT was III degree of therapeutic pathomorphosis (TP) in 44 (40.0%) patients of group 1 and in 21 patients – IV-degree TP, amounting to 46.6%. The median follow-up was 28.7 (from 3.6 to 51.1) months. During this time, 30 patients died in both groups (17 [15.5%] and 13 [28.9%]) (p = 0.047). Disease progression occurred in 16 (10.3%) patients (6 [5.5%] and 10 [22.2%]) (p = 0.004), respectively. The 3-year OS was 83.8 ± 3.7 and 71.0 ± 6.8 (p = 0.131), PFS – 93.5 ± 2.6 and 77.7 ± 6.6 (p = 0.006).Conclusions. The proposed method of surgical treatment of IIA–IIIB stages of cervical cancer has a novelty and can be used in practical medicine for the surgical treatment of oncology diseases in cervical cancer
”Gör plats!”
Authors: Apelmo Elisabet , Alftberg Åsa 
Published: January 2023

”Make room!” Concerning ableism, paternalism and the construction of dis/ability Within the social work profession, social vulnerability and social justice are central concerns. However, professional emphasis is on economic and social conditions and less on dis/ability, despite the fact that dis/ability is important, not only for services aimed specifically at people with dis/abilities, but the entire profession of social work is linked to dis/ability in various ways. The purpose of the article is to contribute to a deepened understanding of vulnerability in general and, in particular, the vulnerability of people with dis/abilities. An advertisement from the Swedish Public Employment Service’s campaign “Make room!” forms a point of departure for a theoretical discussion of how dis/ability is constructed. The article demonstrates how the advertisement is based on paternalistic and ableistic ways of thinking that connect dis/ability, gender, and race/ethnicity. Able-bodied perfection is regarded as desirable, while the deviant body is linked to deficiency and suffering. The article also deals with the critical discussion that followed the advertisement, which eventually led to the Swedish Public Employment Service withdrawing it. Finally, we argue in favour of a cripistemological perspective in social work. This means taking previously marginalized knowledge as a starting point and reformulate traditional perspectives. It also means seeking cross-border cooperation between social work and the disability rights movement as well as other social movements. Thus, the lived experience of vulnerability that can result from impairment and its effects, as well as the political vulnerability that arises due to lack of resources, are made visible, without vulnerability being interpreted from paternalistic and ableistic perspectives. Moreover, ideas of the normal body and the normal way of thinking and feeling can be
Bismuth-coated 80S15C bioactive glass scaffolds for photothermal antitumor therapy and bone regeneration
Authors: Du Jianhang , Ding Huifeng , Fu Shengyang , Li Dejian , Yu Bin 
Published: January 2023

Background: Malignant bone tumors usually occur in young people and have a high mortality and disability rate. Surgical excision commonly results in residual bone tumor cells and large bone defects, and conventional radiotherapy and chemotherapy may cause significant side effects. In this study, a bifunctional Bi-BG scaffold for near-infrared (NIR)-activated photothermal ablation of bone tumors and enhanced bone defect regeneration is fabricated.Methods: In this study, we prepared the Bi-BG scaffold by in-situ generation of NIR-absorbing Bi coating on the surface of a 3D-printing bioactive glass (BG) scaffold. SEM was used to analyze the morphological changes of the scaffolds. In addition, the temperature variation was imaged and recorded under 808 nm NIR laser irradiation in real time by an infrared thermal imaging system. Then, the proliferation of rat bone mesenchymal stem cells (rBMSCs) and Saos-2 on the scaffolds was examined by CCK-8 assay. ALP activity assay and RT-PCR were performed to test the osteogenic capacity. For in vivo experiments, the nude rat tumor-forming and rat calvarial defect models were established. At 8 weeks after surgery, micro-CT, and histological staining were performed on harvested calvarial samples.Results: The Bi-BG scaffolds have outstanding photothermal performance under the irradiation of 808 nm NIR at different power densities, while no photothermal effects are observed for pure BG scaffolds. The photothermal temperature of the Bi-BG scaffold can be effectively regulated in the range 26–100°C by controlling the NIR power density and irradiation duration. Bi-BG scaffolds not only significantly induces more than 95% of osteosarcoma cell death (Saos-2) in vitro, but also effectively inhibit the growth of bone tumors in vivo. Furthermore, they exhibit excellent capability in promoting osteogenic differentiation of rBMSCs and finally enhance new bone formation in the calvarial defects of rats.Conclusion: The Bi-BG scaffolds have bifunctional properties of photothermal antitumor therapy and bone regeneration, which offers an effective method to ablate malignant bone tumors based on photothermal effect.
Low-Intensity Pulsed Ultrasound Promotes Osteogenic Potential of iPSC-Derived MSCs but Fails to Simplify the iPSC-EB-MSC Differentiation Process
Authors: Hua Ziyi , Li Shuang , Liu Qianzi , Yu Minxuan , Liao Mengling , Zhang Hongmei , Xiang Xuerong , Wu Qingqing 
Published: January 2023

Graphical AbstractWe demonstrate LIPUS at the intensity of 40mW/cm2 and the D.C of 50% (LIPUS40/50) can enhance the osteogenic potential of iMSCs in vitro and in vivo. LIPUS40/50 seems to accelerate EB-iMSC transition, but itfails to convert iPSCs or EB cells into osteoblasts directly. These results represent an important step toward applying iPSCs safely and effectively in bone tissue engineering.
Expression and clinical significance of short-chain fatty acids in pregnancy complications
Authors: Chen Siqian , Li Jialin , Ren Shuaijun , Gao Yajie , Zhou Yuping , Xuan Rongrong 
Published: January 2023

ObjectiveTo investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance.MethodsTargeted metabonomics was used to detect SCFAs in the serum of 28 GDM pregnant women, 28 PE pregnant women, 29 ICP pregnant women, and 27 healthy pregnant women (NP); their expression changes were observed; the correlation between SCFAs and clinical characteristics was studied; and their potential as biomarkers for clinical diagnosis was evaluated.ResultsThere were significant differences in the SCFA metabolic spectrum between the GDM, PE, ICP, and NP groups. Quantitative analysis showed that the content of isobutyric acid in the three pregnancy complications groups (the GDM, PE, and ICP groups) was significantly higher than that in the NP group (p &lt; 0.05), and other SCFAs also showed significant differences in the three pregnancy complications groups compared with the NP group (p &lt; 0.05). Receiver operating characteristic (ROC) curve analysis of the generalized linear model showed that multiple SCFAs were highly sensitive and specific as diagnostic markers in the pregnancy complications groups, where isobutyric acid was highly predictive in GDM (area under the ROC curve (AUC) = 0.764) and PE (AUC = 1), and caproic acid was highly predictive in ICP (AUC = 0.968), with potential clinical application.ConclusionThe metabolic products of intestinal flora, SCFAs, during pregnancy are closely related to pregnancy complications (GDM, PE, and ICP), and SCFAs can be used as potential markers of pregnancy complications.
Oxymatrine ameliorates experimental autoimmune encephalomyelitis by rebalancing the homeostasis of gut microbiota and reducing blood-brain barrier disruption
Authors: Zhang Ming-Liang , Li Wei-Xia , Wang Xiao-Yan , Wu Ya-Li , Chen Xiao-Fei , Zhang Hui , Yang Liu-Qing , Wu Cheng-Zhao , Zhang Shu-Qi , Chen Yu-Long , Feng Ke-Ran , Wang Bin , Niu Lu , Kong De-Xin , Tang Jin-Fa 
Published: January 2023

BackgroundIncreasing evidence suggests that gut dysbiosis can directly or indirectly affect the immune system through the brain-gut axis and play a role in the occurrence and development of Multiple sclerosis (MS). Oxymatrine (OMAT) has been shown to ameliorate the symptoms of MS in the classical experimental autoimmune encephalomyelitis (EAE) model of MS, but whether its therapeutic role is through the correction of gut dysbiosis, is unclear.MethodsThe effects of OMAT on intestinal flora and short-chain fatty acids in EAE model mice were evaluated by 16S rRNA sequencing and GC-MS/MS, respectively, and the function change of the blood-brain barrier and intestinal epithelial barrier was further tested by immunohistochemical staining, Evans Blue leakage detection, and RT-qPCR.ResultsThe alpha and beta diversity in the feces of EAE mice were significantly different from that of the control group but recovered substantially after OMAT treatment. Besides, the OMAT treatment significantly affected the gut functional profiling and the abundance of genes associated with energy metabolism, amino acid metabolism, the immune system, infectious diseases, and the nervous system. OMAT also decreased the levels of isobutyric acid and isovaleric acid in EAE mice, which are significantly related to the abundance of certain gut microbes and were consistent with the reduced expression of TNF-a, IL-6, and IL-1b. Furthermore, OMAT treatment significantly increased the expression of ZO-1 and occludin in the brains and colons of EAE mice and decreased blood-brain barrier permeability.ConclusionOMAT may alleviate the clinical and pathological symptoms of MS by correcting dysbiosis, restoring gut ecological and functional microenvironment, and inhibiting immune cell-mediated inflammation to remodel the brain-gut axis.
Abatement of potent P2Y12 antagonist-based dual antiplatelet therapy after coronary intervention: A network meta-analysis of randomized controlled trials
Authors: El Alaoui El Abdallaoui Oumaima , Tornyos Dániel , Lukács Réka , Komócsi András 
Published: January 2023

IntroductionDual antiplatelet therapy (DAPT) including prasugrel or ticagrelor is recommended in patients with acute coronary syndromes (ACS) treated with coronary intervention (PCI). Acknowledging the importance of bleeding, multiple trials tested abatement schemes including uniform or guided de-escalation from the potent P2Y12 inhibitor (P2Y12-De) or P2Y12 inhibitor monotherapy (P2Y12-Mo) with heterogeneous results. We aimed to perform a systematic review and network meta-analysis of the impact of DAPT abatement strategies in patients with PCI.MethodsElectronic databases were searched for relevant randomized clinical studies evaluating clinical outcomes of patients after PCI. The rate of adverse events was evaluated using a frequentist network metanalysis. The random-effects model was used to combine risk estimates across trials and risk ratio (RR) with 95% confidence intervals (95% CIs) served as summary statistics. The primary endpoints of interest were the rate of major cardiac adverse events (MACE, defined as the composite of cardiovascular mortality, myocardial infarction and stroke) and bleeding.ResultsTen studies were identified randomizing 42511 patients. 6359 switched to the P2Y12-De and 13062 switched to the P2Y12-Mo. The risk of MACE, reflected a 24% reduction in the P2Y12-De and a 14% in the P2Y12-Mo in comparison with the DAPT strategy using potent P2Y12 inhibitors (RR: 0.76 [0.62, 0.94], and RR: 0.86 [0.75, 0.99], p &lt; 0.05 both). A 35% risk reduction of major bleeding was seen with monotherapy (RR: 0.65 [0.46, 0.91],) contrasting the de-escalation trials where this effect was not significant (RR: 0.84 [0.57, 1.22]). All bleeding and minor bleeding events were reduced with both strategies. Indirect P2Y12-Mo versus P2Y12-De comparisons exhibited them as similar alternatives without significant differences.ConclusionOur analysis suggests that both P2Y12-De and P2Y12-Mo reduce ischemic events and bleeding among PCI-treated ACS patients. Ischemic benefit was more expressed with P2Y12-De, however, reduction of major bleeding was only significant with P2Y12-Mo strategy.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021258502, identifier CRD42021258502.
Traditional risk factors and cancer-related factors associated with cardiovascular disease risk in head and neck cancer patients
Authors: Mukherjee Amrita , Wiener Howard W. , Griffin Russell L. , Lenneman Carrie , Chatterjee Arka , Nabell Lisle M. , Lewis Cora E. , Shrestha Sadeep 
Published: January 2023

BackgroundRisk of incident cardiovascular disease (CVD) in head and neck squamous cell carcinoma (HNSCC) patients is under-reported. We assessed the association of HNSCC-related factors and traditional risk factors with 1- and 5-year CVD risk in HNSCC patients without prevalent CVD at cancer diagnosis.MethodsA clinical cohort of 1,829 HNSCC patients diagnosed between 2012 and 2018, at a National Cancer Institute (NCI)-designated cancer center was included. Information on HNSCC-related factors [HNSCC anatomical subsite, stage at diagnosis, treatment, and tumor human papillomavirus (HPV) status] were extracted from the tumor registry. Data on traditional risk factors (hypertension, dyslipidemia, diabetes, tobacco smoking status, and obesity) were extracted from the electronic health records system (EHR) at baseline (HNSCC diagnosis). A composite of ischemic heart disease, heart failure, and ischemic stroke was the outcome of interest in time to event analysis. Hazard ratio (HR) (95% CI) were reported with death as a competing risk.ResultsIn patients diagnosed with HNSCC, 10.61% developed incident CVD events by 1-year post cancer diagnosis. One-year CVD risk was lower in patients using antihypertensive medications at baseline, compared to patients without baseline hypertension [HR (95% CI): 0.41 (0.24–0.61)]. One-year CVD risk was high in patients receiving HNSCC surgery. Patients receiving radiation therapy had a higher 5-year CVD risk than surgery patients [HR (95% CI): 2.17 (1.31–3.04)]. Patients using antihypertensive medications had a lower 5-year CVD risk than patients without baseline hypertension [HR (95% CI): 0.45 (0.22–0.75)]. Older age and diabetes were associated with increased 1- and 5-year CVD risk. HPV-negative patients were older (p 0.006) and had a higher 5-year cumulative incidence of CVD (p 0.013) than HPV-positive patients.ConclusionTraditional risk factors and cancer-related factors are associated with CVD risk in HNSCC patients. Future research should investigate the role of antihypertensive medications in reducing CVD risk in HNSCC patients.