bluuebunny/crossref_metadata_2025_split huggingface dataset:
Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme
Authors: Wang Xinyue , Chen Qian , Zhu Yefei , Wang Kairuo , Chang Yongliang , Wu Xiawei , Bao Weichao , Cao Tongcheng , Chen Hangrong , Zhang Yang , Qin Huanlong 
Published: July 2023

AbstractThe crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology. Several intratumoral bacteria which have been identified as pathogens of cancer that induce progression, metastasis, and poor outcome of cancer, while tumor vascular networks and immunosuppressive microenvironment provide shelters for pathogens localization. Thus, the mutually-beneficial interplay between pathogens and tumors, named “pathogen-tumor symbionts”, is probably a potential therapeutic site for tumor treatment. Herein, we proposed a destroying pathogen-tumor symbionts strategy that kills intratumoral pathogens,F. nucleatum, to break the symbiont and synergize to kill colorectal cancer (CRC) cells. This strategy was achieved by a groundbreaking protein-supported copper single-atom nanozyme (BSA-Cu SAN) which was inspired by the structures of native enzymes that are based on protein, with metal elements as the active center. BSA-Cu SAN can exert catalytic therapy by generating reactive oxygen species (ROS) and depleting GSH. The in vitro and in vivo experiments demonstrate that BSA-Cu SAN passively targets tumor sites and efficiently scavengesF. nucleatumin situ to destroy pathogen-tumor symbionts. As a result, ROS resistance of CRC through elevated autophagy mediated byF. nucleatumwas relieved, contributing to apoptosis of cancer cells induced by intracellular redox imbalance generated by BSA-Cu SAN. Particularly, BSA-Cu SAN experiences renal clearance, avoiding long-term systemic toxicity. This work provides a feasible paradigm for destroying pathogen-tumor symbionts to block intratumoral pathogens interplay with CRC for antitumor therapy and an optimized trail for the SAN catalytic therapy by the clearable protein-supported SAN.
Non-contact heart vibration measurement using computer vision-based seismocardiography
Authors: Rahman Mohammad Muntasir , Cook Jadyn , Taebi Amirtahà 
Published: July 2023

AbstractSeismocardiography (SCG) is the noninvasive measurement of local vibrations of the chest wall produced by the mechanical activity of the heart and has shown promise in providing clinical information for certain cardiovascular diseases including heart failure and ischemia. Conventionally, SCG signals are recorded by placing an accelerometer on the chest. In this paper, we propose a novel contactless SCG measurement method to extract them from chest videos recorded by a smartphone. Our pipeline consists of computer vision methods including the Lucas–Kanade template tracking to track an artificial target attached to the chest, and then estimate the SCG signals from the tracked displacements. We evaluated our pipeline on 14 healthy subjects by comparing the vision-based SCG$$^\mathrm{{v}}$$vestimations with the gold-standard SCG$$^\mathrm{{g}}$$gmeasured simultaneously using accelerometers attached to the chest. The similarity between SCG$$^\mathrm{{g}}$$gand SCG$$^\mathrm{{v}}$$vwas measured in the time and frequency domains using the Pearson correlation coefficient, a similarity index based on dynamic time warping (DTW), and wavelet coherence. The average DTW-based similarity index between the signals was 0.94 and 0.95 in the right-to-left and head-to-foot directions, respectively. Furthermore, SCG$$^\mathrm{{v}}$$vsignals were utilized to estimate the heart rate, and these results were compared to the gold-standard heart rate obtained from ECG signals. The findings indicated a good agreement between the estimated heart rate values and the gold-standard measurements (bias = 0.649 beats/min). In conclusion, this work shows promise in developing a low-cost and widely available method for remote monitoring of cardiovascular activity using smartphone videos.
A polarization‐insensitive ultra‐wideband absorber based on hybrid structure
Authors: Xue Kun , Sun Haoliang , Qin Yifeng , Zhu Hongyi , Dong Shaohua 
Published: July 2023

AbstractWith the continuous improvement of detection technology, the survivability of targets on the battlefield is facing great challenges. Consequently, microwave absorbers with stealth characteristics are of important research value to modern military. Aim at solving the problems of narrow bandwidth or complex structure, an implementation model of ultra‐wideband (UWB) absorber based on hybrid structure is proposed. In this letter, a polarization‐insensitive ultra‐wideband absorber (PIUWA) is designed, manufactured, and characterized, which has a good absorptivity of more than 90% ranges from 4 to 24.53GHz (the fractional bandwidth [FBW] is 144%) by triggering multiple resonance peaks in the hybrid structure. In addition, the subwavelength periodicity of the PIUWA is theoretically beneficial to the angular stability under full‐wave polarizations. The operating mechanism of the PIUWA is demonstrated by the equivalent circuit model and the correctness of the design is verified by experimental measurements. This letter contributes to the approach of designing and fabricating UWB microwave absorbers with high absorptivity, good angular stability, and simpler assembly procedure.
Fundamental‐mode EMSIW for miniaturized differential antenna with high CM rejection
Authors: Fu Xuedong , Sun Mingyu , Chen Aixin 
Published: July 2023

AbstractThis letter proposes a novel miniaturization approach for differential antennas using fractional‐mode substrate integrated waveguide (SIW) fundamental‐mode. Symmetrically arranging dual miniaturized cavities, in‐phase DM magnetic currents are constructed to superimpose differential‐mode (DM) E‐fields for enhanced radiation while simultaneously constructing reverse common‐mode (CM) magnetic currents to cancel the CM E‐fields and suppress the CM signal. Three kinds of eighth‐mode SIW differential antennas with boundary symmetry are designed to verify the approach. Analysis of the equivalent circuit models reveals that the DM resonant frequency is lower than the CM resonant frequency, effectively suppressing CM signal within the DM passband through impedance mismatch reflection and radiation E‐fields cancellation. The measured and simulated results show good agreement. The size of the miniaturized antenna is 0.460.012 , with a high CM rejection of 31.4 dB achieved.
A Spherical Shells Model of Atmospheric Absorption for Instrument Calibration
Authors: Donders N , Vigil G , Kobelski A , Paxton L J , Winebarger A , Kankelborg C , Zank G P 
Published: July 2023

Abstract
We present a model for atmospheric absorption of solar ultraviolet (UV) radiation. The initial motivation for this work is to predict this effect and correct it in Sounding Rocket (SR) experiments. In particular, the Full-sun Ultraviolet Rocket Spectrograph (FURST) is anticipated to launch in mid-2023. FURST has the potential to observe UV absorption while imaging solar spectra between 120-181 nm, at a resolution of

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, and at altitudes of between ≈ 110-255 km. This model uses estimates for density and temperature, as well as laboratory measurements of the absorption cross-section, to predict the UV absorption of solar radiation at high altitudes. Refraction correction is discussed and partially implemented but is negligible for the results presented. Absorption by molecular Oxygen is the primary driver within the UV spectral range of our interest. The model is built with a wide range of applications in mind. The primary result is a method for inversion of the absorption cross-section from images obtained during an instrument flight, even if atmospheric observations were not initially intended. The potential to obtain measurements of atmospheric properties is an exciting prospect, especially since sounding rockets are the only method currently available for probing this altitude in-situ. Simulation of noisy spectral images along the FURST flight profile is performed using data from the High-Resolution Telescope and Spectrograph (HRTS) SR and the FISM2 model for comparison. Analysis of these simulated signals allows us to capture the Signal-to-Noise Ratio (SNR) of FURST and the capability to measure atmospheric absorption properties as a function of altitude. Based on the prevalence of distinct spectral features, our calculations demonstrate that atmospheric absorption may be used to perform wavelength calibration from in-flight data.
Magnetic flux rope: What is it?
Authors: Hu Qiang 
Published: July 2023

Abstract
Magnetic flux rope, a type of magnetic field structure in space plasmas, has been studied for decades through both observational and theoretical means. We provide a brief report on our recent modeling study of its magnetic field configuration based on in-situ spacecraft measurements, focusing on those made for large-scale flux ropes in the interplanetary space. We illustrate the complexity in its field-line topology by presenting two event studies employing a unique analysis method. In particular, we demonstrate the feasibility and challenges for the approach to use two or more in-situ spacecraft datasets. We discuss the implications of our results and offer some thoughts on further advancing the investigation of the nature of the magnetic flux rope.
Body Composition Measures and N-terminal pro-B-type Natriuretic Peptide (NT-pro-BNP) in US Adults
Authors: Echouffo-Tcheugui Justin B , Zhang Sui , McEvoy John W , Juraschek Stephen P , Coresh Josef , Christenson Robert H , Ndumele Chiadi E , Selvin Elizabeth 
Published: July 2023

Abstract

Background
The associations of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with dual energy x-ray absorptiometry (DEXA)-derived measures of body mass and composition are largely unknown.

Methods
We included participants aged ≥20 years from the 1999–2004 National Health and Nutrition Examination Survey with NT-pro-BNP and DEXA-derived body composition (fat and lean mass) measures. We used linear and logistic regression to characterize the associations of measures of body mass and composition (body mass index [BMI], waist circumference [WC], fat mass, and lean mass) with NT-pro-BNP, adjusting for cardiovascular risk factors.

Results
We conducted sex-specific analyses among 9134 adults without cardiovascular disease (mean age 44.4 years, 50.8% women, and 72% White adults). The adjusted mean NT-proBNP values were lowest in the highest quartiles of BMI, WC, fat mass, and lean mass. There were large adjusted absolute differences in NT-pro-BNP between the highest and lowest quartiles of DEXA-derived lean mass, −6.26 pg/mL (95% confidence interval [CI], −8.99 to −3.52) among men and −22.96 pg/mL (95% CI, −26.83 to −19.09) among women. Lean mass exhibited a strong inverse association with elevated NT-pro-BNP ≥ 81.4 pg/mL (highest quartile) - odds ratio (OR) 0.58 (95% CI, 0.39–0.86) in men and OR 0.59 (95% CI, 0.47–0.73) in women for highest lean mass quartile vs. lowest quartile. Further adjustment for fat mass, BMI, or WC did not appreciably alter the inverse association of lean mass with NT-pro-BNP.

Conclusions
In a national sample of US adults, lean mass was inversely associated with NT-pro-BNP.
Urinary Kidney Injury Biomarkers Are Associated with Ischemia-Reperfusion Injury Severity in Kidney Allograft Recipients
Authors: van Duijl Tirsa T , de Rooij Esther N M , Treep Maxim M , Koelemaij Marte E , Romijn Fred P H T M , Hoogeveen Ellen K , Ruhaak L Renee , le Cessie Saskia , de Fijter Johan W , Cobbaert Christa M 
Published: July 2023

Abstract

Background
We explored the potential of emerging and conventional urinary kidney injury biomarkers in recipients of living donor (LD) or donation after circulatory death (DCD) kidney transplantation, patients with chronic kidney disease (CKD), and individuals from the general population.

Methods
Urine samples from kidney allograft recipients with mild (LD; n = 199) or severe (DCD; n = 71) ischemia-reperfusion injury (IRI) were analyzed for neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinases 2 (TIMP2), kidney injury molecule-1 (KIM-1), chemokine C-X-C motif (CXCL9), solute carrier family 22 member 2 (SLC22A2), nephrin, and uromodulin (UMOD) by quantitative multiplex LC-MS/MS analysis. The fold-change in biomarker levels was determined in mild and severe IRI and in patients with CKD stage 1–2 (n = 127) or stage ≥3 (n = 132) in comparison to the general population (n = 1438). Relationships between the biomarkers and total protein, β2-microglobulin (B2M), creatinine, and osmolality were assessed.

Results
NGAL, IGFBP7, TIMP2, KIM-1, CXCL9, and UMOD were quantifiable, whereas nephrin and SLC22A2 were below the limit of detection. Kidney injury biomarkers were increased up to 6.2-fold in allograft recipients with mild IRI and 8.3-fold in recipients with severe IRI, compared to the reference population, with the strongest response observed for NGAL and B2M. In CKD stage 1–2, B2M, NGAL, IGFBP7, TIMP2, KIM-1, UMOD, and CXCL9 were not altered, but in individuals with CKD stage ≥3, B2M, NGAL, and KIM-1 were increased up to 1.3-fold. IGFBP7, TIMP2, NGAL, and CXCL9 were strongly correlated (all r ≥ 0.8); correlations with B2M and TP were smaller (all r ≤ 0.6).

Conclusions
IRI, but not stable CKD, was associated with increased urinary levels of kidney injury biomarkers determined by LC-MS/MS. Absolute and multiplexed protein quantitation by LC-MS/MS is an effective strategy for biomarker panel evaluation for translation toward the clinical laboratory.
Formation and Replacement of Bone and Tooth Mineralized Tissues in Green Iguanas (Iguana iguana) Revealed by In-Vivo Fluorescence Marking
Authors: Green Daniel R , Winkler Daniela E , Leichliter Jennifer N , Harms Gregory S , Hatt Jean-Michel , Clauss Marcus , Tütken Thomas 
Published: July 2023

Synopsis
Hard tissue formation patterns and rates reveal details of animal physiology, life history, and environment, but are understudied in reptiles. Here, we use fluorescence labels delivered in vivo and laser confocal scanning microscopy to study tooth and bone formation in a managed group of green iguanas (Iguana iguana, Linné 1758) kept for 1.5 years under experimentally controlled conditions and undergoing several dietary switches. We constrain rates of tooth elongation, which we observe to be slow when enamel is initially deposited (c. 9 µm/day), but then increases exponentially in the dentin root, reaching c. 55 µm/day or more after crown completion. We further constrain the total timing of tooth formation to ∼40–60 days, and observe highly variable timings of tooth resorption onset and replacement. Fluorescent labels clearly indicate cohorts of teeth recruited within Zahnreihen replacement waves, with faster sequential tooth recruitment and greater wave sizes posteriorly, where each wave initiates. Fluorescence further reveals enamel maturation after initial deposition. Rates of hard tissue formation in long bones range from 0.4 to 3.4 µm/day, correlating with animal weight gain and cortical bone recording the entire history of the experiment. We suggest additional labeling experiments to study hard tissue formation patterns in other reptiles, and propose strategies for chemical analyses of hard tissues in order to extract temporal information about past environments, behaviors, and diets from reptilian fossils throughout the Phanerozoic.
Use of a common spreadsheet program to demonstrate the ability of Bayesian forecasting to estimate the pharmacokinetic parameters of antibiotics
Authors: Brocks Dion R , Wang Meng 
Published: July 2023

Abstract

Objectives
Recent guidelines for vancomycin have incorporated the use of Bayesian forecasting, reinforcing the need to inform students in pharmacy and clinical pharmacology of its use in therapeutic drug monitoring. The goal was to devise a PharmD research project that could demonstrate to students through simulation and data generation the utility of the Bayesian approach in estimating the pharmacokinetics of gentamicin and vancomycin.

Methods
A series of steps were devised using Microsoft Excel to simulate patient data based on study-derived means and variances, pharmacokinetic modelling, random selection of sparse blood samples, introduce random error into the selected concentrations based on assay variability measure, and finally, inputting of the information into an add-in computer program to find the pharmacokinetic estimates using Bayesian forecasting.

Key findings
Excellent correlations were seen between Bayesian estimates and true clearances. Lower assay variability tended to provide better estimates than larger assay variability for gentamicin, and for vancomycin, selecting a sample during the distribution phase and near the trough values tended to provide estimates with less bias and greater precision.

Conclusions
The approach used was able to demonstrate all aspects involved in Bayesian forecasting, and the results supported its use for these antibiotics.
The Effectiveness of the Buzzy Device in Reducing Pain in Children Undergoing Venipuncture
Authors: Simoncini Elisa , Stiaccini Giulia , Morelli Elena , Trentini Elisa , Peroni Diego G. , Di Cicco Maria 
Published: July 2023

Objectives
Needle-related procedures are among the most important sources of pain in children in different health care settings. Our study was aimed to evaluate the effectiveness of Buzzy (MMJ Labs, Atlanta, Ga.), a palm-sized bee/ladybug-shaped device combining vibration and cold, as a nonpharmacological strategy to manage needle-related pain in children.

Methods
In this single-center, randomized (1:1) controlled open-label study, we enrolled patients aged from 1 month to 18 years who had to undergo a planned outpatient blood sampling in Pisa University Hospital's Department of Pediatrics and randomly allocated them to either the BUZZY group (intervention group) or NO BUZZY group (control group). Pain was estimated using proper pain scales according to age.

Results
Between May 2021 and January 2022, 234 children aged 8.8 ± 5.1 years (50.8% girls) were enrolled and 117 were treated with the Buzzy device. In the study population, pain inversely correlated with age (r = −0.52, P < 0.001); the intervention group showed significantly lower pain (2.5 ± 2.4 vs 4.7 ± 2.8, P < 0.001) and no difference was found between boys and girls. Significant reduction in pain scores was confirmed when stratifying children by age (29 days to <3 years, P = 0.002; ≥3 to ≤8 years, P < 0.001; >8 years, P < 0.001).

Conclusions
The Buzzy device effectively reduces pain caused by percutaneous antecubital venipuncture in children in different age groups and represents a cheap and easy-to-use strategy to manage routine needle-related procedures.
Ideal Outcome After Pancreatoduodenectomy
Authors: Augustinus Simone , Mackay Tara M , Andersson Bodil , Beane Joal D. , Busch Olivier R. , Gleeson Elizabeth M. , Koerkamp Bas Groot , Keck Tobias , van Santvoort Hjalmar C. , Tingstedt Bobby , Wellner Ulrich F. , Williamsson Caroline , Besselink Marc G. , Pitt Henry A. ,   for Global Audits on Pancreatic Surgery Group (GAPASURG)
Published: July 2023

Introduction:
Assessing outcome after pancreatoduodenectomy among centers and countries requires a broad evaluation which cannot be captured by a single parameter. Previously, two composite outcome measures (Textbook Outcome and Optimal Pancreatic Surgery) for pancreatoduodenectomy have been described from Europe and the United States. These composites were harmonized into one Ideal Outcome (IO).

Methods:
This analysis is a transatlantic retrospective study (2018-2020) of patients after pancreatoduodenectomy within the registries from North America, Germany, the Netherlands, and Sweden. After three consensus meetings, IO for pancreatoduodenectomy was defined as the absence of all six parameters: (1) in-hospital mortality, (2) severe complications - Clavien Dindo ≥3, (3) postoperative pancreatic fistula - ISGPS grade B/C), (4) reoperation, (5) hospital stay >75th percentile, and (6) readmission. Outcomes were evaluated using relative (RLD) and absolute largest differences (ALD), and multivariate regression models.

Results:
Overall, 21,036 patients after pancreatoduodenectomy were included, of whom 11,194 (54%) reached IO. The rate of IO varied between 55% in North America, 53% in Germany, 52% in the Netherlands, and 54% in Sweden (RLD: 1.1, ALD: 3%, P<0.001). Individual components varied with an ALD of 2% length of stay, 4% for in-hospital mortality, 12% severe complications, 10% postoperative pancreatic fistula, 11% reoperation, and 9% readmission. Age, sex, absence of COPD, BMI, performance status, ASA score, biliary drainage, absence of vascular resection, and histological diagnosis were associated with IO. In the subgroup of patients with pancreatic adenocarcinoma, country and neoadjuvant chemotherapy also was associated with improved IO.

Conclusion:
The newly developed composite outcome measure ‘Ideal Outcome’ can be used for auditing and comparing outcomes after pancreatoduodenectomy. The observed differences can be used to guide collaborative initiatives to further improve outcomes of pancreatic surgery.
A training system on smart phones to develop fashion and textile concepts for the female students with severe hearing impairment
Authors: Salem Shadia Salah , Basaffar Amaal Abdulqader 
Published: July 2023

PurposeThe purpose of this study is to present a training system on smart phones to develop fashion and textile concepts among the female students with severe hearing impairment and then to determine the effectiveness of the training system in developing fashion and textile concepts among the female students with severe hearing impairment.Design/methodology/approachThe analytical descriptive methodology and experimental methodology were used to examine the training system in developing fashion and textile concepts among the female students with severe hearing impairment.FindingsThe findings of this study indicate that the training system on smart phones was effective in developing fashion and textile concepts among the female students with severe hearing impairment.Research limitations/implicationsThis study has some limitations such as limited sample size, lack of control group and lack of long-term.Practical implicationsThis study provides practical implications for educators, researchers and practitioners in terms of using smart phone applications in educational processes for people with disabilities.Social implicationsThis study has social implications for people with disabilities as it provides them with access to education through smart phone applications which can help them develop their skills in fashion and textile design.Originality/valueThis study presents an original model of a training system on smart phones for developing fashion and textile concepts among the female students with severe hearing impairment, which can be used as a reference for other studies related to this field.