bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 48-node All-to-all Connected Coupled Ring Oscillator Ising Solver Chip
Authors: Lo Hao , Moy William , Yu Hanzhao , Sapatnekar Sachin , Kim Chris H. 
Published: January 2023

Abstract
This paper presents a physics-based Ising solver chip fabricated in a standard 1.2V, 65 nanometer complementary metal oxide semiconductor (CMOS) technology featuring an all-to-all architecture with 48 spins and a highly-uniform coupling circuit with integer weights ranging from -14 to +14. Existing locally-connected architectures suffer from size and digital computation overheads while embedding an arbitrary graph. In contrast, our all-to-all connected design allows any graph with up to 48 nodes to be directly mapped to the hardware. The key idea of the all-to-all architecture is to strongly couple a horizontal oscillator with a vertical oscillator so that each horizontal-vertical oscillator pair intersects with all other pairs in the cross-bar style array. The multi-bit coupling circuit was realized by cascading 1-bit coupler stages comprising a pair of inverters and two transmission gates. Statistical measurements were carried out on the fabricated Ising solver chips for different problem sizes, graph densities, operating temperatures, problem instances, and solution samples. The measured oscillation period, power consumption, and relaxation time for different problems are also reported. Finally, we show that dynamically merged spins can achieve higher weight resolution without hardware changes.
Association of Polycyclic Aromatic Hydrocarbon Metabolite Concentration in Urine and Occupational Stress in Underground Coal Miners, China
Authors: Zhang Hongmei , Cao Jingjing , Liu Aixiang , Gao Qian , Nie Jisheng , Zhou Xiaoling , Huang Jianjun , Sun Chenming , Wang Tong 
Published: January 2023

Abstract
This study intends to examine the association of urinary PAHs metabolite concentration and occupational stress in coal miners. We sampled 671 underground coal miners from Datong, China, assessed their occupational stress using the Occupational Stress Inventory-Revised edition (OSI-R), and categorized them into the high stress group and controls based on the occupational stress assessment. We determined urinary hydroxyl PAHs (OH-PAHs) concentrations using the ultrahigh performance liquid chromatography-tandem mass spectrometry, and analyzed the association of OH-PAHs concentration with occupational stress using multiple linear regression and covariate balancing generalized propensity score. The low molecular weight (LMW) OH-PAHs and its quartiles were positively associated with Occupational Role Questionnaire (ORQ) score. The OH-PAHs concentration was not associated with PSQ or PRQ score. The OH-PAHs concentration in urine was positively associated with ORQ score in coal miners, particularly the LMW OH-PAHs. Non-association was found in the OH-PAHs concentration with PSQ or PRQ scores.
Cross-talk between carbon monoxide and hydrogen sulfide on the CBS expression and neurotoxicity induced by Chronic Kidney Disease in the male rats
Authors: Hamidizad Zeinab , Kadkhodaee Mehri , Kianian Farzaneh , Ranjbaran Mina , Seifi Behjat 
Published: January 2023

Abstract

Neurotoxicity is implicated as a severe complication of chronic kidney disease (CKD). Accumulation of urea and other toxic compounds leads to oxidative stress, inflammation, and destruction of the blood-brain barrier. Carbon monoxide (CO) and hydrogen sulfide (H2S) have been shown to have anti-inflammatory, anti-apoptotic, and anti-proliferative properties. The present study aimed to evaluate the protective effects of CO-releasing molecule (CORM3) and H2S donor (NaHS) on oxidative stress and neuronal death induced by CKD in the hippocampus and prefrontal cortex by considering theinteraction between CO and H2S on CBS expression. CORM3 or NaHS significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid peroxidationand reduced neuronal death in the hippocampus and prefrontal cortex and, improved the markers of renal injury induced by CKD. In addition, CORM3 or NaHS significantly improved CBS expression which wasreduced by CKD. However, improving effects of CORM3 on antioxidant defense mechanisms, lipid peroxidation, neuronal death, renal injury, and CBS expression was prevented by amino-oxy acetic acid (AOAA) (CBS inhibitor) and reciprocally improving effects of NaHS on all above indices were prevented by zinc protoporphyrin IX (Znpp) (HO-1 inhibitor). In conclusion, this study demonstrated that the formation of CO and H2S interdependently improved CKD-induced oxidative stress and neuronal death, which may bethrough increased expression of CBS.
The Use of “Damage Control Orthopedics” Strategy in the Treatment of Severe Gunshot Wounds of the Limbs
Authors: Domanskyi Andriy , Tomilin Valerii , Tomilin Mykyta 
Published: January 2023

AbstractObjectives. The objectives of this study were to evaluate the incidence and nature of gunshot wounds of the limbs in the general structure of combat trauma, and study the features of DCO (Damage Control Orthopedics) patient management strategy in the conditions of a regional hospital as a stage of care for this pathology. Background. Limb injuries account for between 52.3% and 60.1% of combat casualties. The problem of surgical management of limb gunshot wounds is of particular relevance at the present stage of active use of firearms. Thus, adequate choice of surgical treatment strategy for limb gunshot wounds is an important condition for preserving life and preventing severe complications in combat casualties. Methods. The study was conducted among 1000 injured from the combat zone during the period from 24.02.22 to 15.04.22. The trauma and orthopedic surgery department of "Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov" mainly performed secondary surgical debridement of wounds, comprehensive surgical and medical prevention of complications in the injured. Injury severity was assessed using the ISS (Injury Severity Score) based on the AIS (Abbreviated Injury Scale), which assesses the severity of injuries to several areas of the body. Results. DCO strategy was used in 287 (55.1%) injured patients in severe and extremely severe condition (16 points or higher on the ISS scale). A total of 602 surgical operations were performed in 287 injured patients. On average, 2.1 ± 0.6 interventions per one injured person were performed. Overall mortality among victims with gunshot wounds of the limbs was 3.6% (19 wounded out of 521). In all cases there were polytrauma (100%), in 4 (21.1%) cases they were through-and-through injuries, in 2 (10.5%) - with the compartment syndrome development. Conclusions. Differentiated DCO strategy in the surgical treatment of the critically and severely injured (16 points and above on the ISS scale) are essential to save the lives of soldiers in the first period of traumatic illness and to prevent complications of the second and third periods of traumatic illness.
Genetic Risk Assessment of Lethal Prostate Cancer Using Polygenic Risk Score and Hereditary Cancer Susceptibility genes
Authors: Ruan Xiaohao , Huang Da , Huang Jingyi , Tsu James Hok-Leung , Na Rong 
Published: January 2023

Abstract
Background
The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-established risk factor for aggressive PCa, we hypothesize that polygenic risk score (PRS) based on benign prostate hyperplasia (BPH) or PV-related SNPs may also predict the risk of aggressive PCa or PCa death.
Methods
We evaluated a PRS using 27 BPH/PV-associated SNPs, two established PCa risk-related PRS and 10 guideline-recommended hereditary cancer risk genes in the population-based UK Biobank cohort (N = 209,910).
Results
The BPH/PV PRS was significantly inversely associated with the incidence of lethal PCa as well as the natural progress in PCa patients (hazard ratio, HR = 0.92, 95% confidence interval [CI]: 0.85–0.99, P = 0.03; HR = 0.92, 95%CI: 0.86–0.99, P = 0.02). Compared with men at top 25th PRS, PCa patients with bottom 25th PRS would have a 1.40-fold (HR, 95%CI: 1.16–1.69, P = 0.001) increased PCa fatal risk and shorter survival time at 0.37 year (95%CI: 0.14–0.61, P = 0.002). In addition, patients with BRCA2 or PALB2 pathogenic mutations would also have a high risk of PCa death (HR = 3.91, 95%CI: 2.34–6.51, P < 0.001; HR = 4.24, 95%CI: 1.34–13.34, P = 0.01, respectively). However, no interactive but independent effects were detected between this PRS and pathogenic mutations.
Conclusions
Our findings provide a new measurement of PCa patients’ natural disease outcomes via genetic risk ways.
recO enhances resistance of Pasteurella multocida to fluoroquinolones
Authors: Li Xue-song , Xue Jun-ze , Qi Yu , Hu Ren-ge , Muhammad Inam , Gao Yun-hang , Wu Tong-lei , Kong Ling-cong , Ma Hong-xia 
Published: January 2023

Abstract
Pasteurella multocida capsular type A (PmA) is one of the main pathogens causing bovine respiratory disease in China. The prevention and control measures against Pm are traditionally based on the use of broad-spectrum antibiotics. Previous studies found that Pm was prone to antibiotic resistance and tolerance mutation under the action of low concentrations of antibiotics, ultimately causing difficulties in prevention and control against Pm. In this study, highly pathogenic Pm fluoroquinolone-sensitive strain P3 and fluoroquinolone-resistant strain P32 induced by sub-inhibitory concentration of enrofloxacin were selected as research objects. RNA-seq was used to screen the differential gene recO of SOS response of P3 and P32 for functional verification. In addition, through MIC, MBC, induced resistance time, time-kill curve analysis and antibiotic tolerance test, the effect of recO gene on the resistance and tolerance of Pm to fluoroquinolone was clarified. At the same time, using fluorescent reporter vector, it was found that recO gene affected SOS repair response. In conclusion, the inhibition of recO gene can not only reduce their resistance to fluoroquinolone, but also prolong the formation time of fluoroquinolone resistance. It is speculated that recO gene is a potential target of fluoroquinolone synergistic antibacterial agent.
“I am scared, I do not want to lie”: Exploring the impacts of COVID-19 on engagement in care, perceived health, relationship dynamics, and parenting among postpartum women with HIV in South Africa
Authors: Stanton Amelia M. , Blyler Abigail P. , Mosery Nzwakie , Goodman Georgia R. , Vanderkruik Rachel , Sithole Kedibone , Bedoya C. Andres , Smit Jennifer , Psaros Christina 
Published: January 2023

Abstract
Background
COVID-19 and efforts to manage widespread infection may compromise HIV care engagement. The COVID-19-related factors linked to reduced HIV engagement have not been assessed among postpartum women with HIV, who are at heightened risk of attrition under non-pandemic circumstances. To mitigate the effects of the pandemic on care engagement and to prepare for future public health crises, it is critical to understand how COVID-19 has impacted (1) engagement in care and (2) factors that may act as barriers to care engagement.
Methods
A quantitative assessment of COVID-19-related experiences was added to a longitudinal cohort study assessing predictors of postpartum attrition from HIV care among women in South Africa. Participants (N = 266) completed the assessment at 6, 12, 18, or 24 months postpartum between June and November of 2020. Those who endorsed one or more challenge related to engagement in care (making or keeping HIV care appointments, procuring HIV medications, procuring contraception, and/or accessing immunization services for infants; n = 55) were invited to complete a brief qualitative interview, which explored the specific factors driving these challenges, as well as other impacts of COVID-19 on care engagement. Within this subset, 53 participants completed an interview; qualitative data were analyzed via rapid analysis.
Results
Participants described key challenges that reduced their engagement in HIV care and identified four other domains of COVID-19-related impacts: physical health, mental health, relationship with a partner or with the father of the baby, and motherhood/caring for the new baby. Within these domains, specific themes and subthemes emerged, with some positive impacts of COVID-19 also reported (e.g., increased quality time, improved communication with partner, HIV disclosure). Coping strategies for COVID-19-related challenges (e.g., acceptance, spirituality, distraction) were also discussed.
Conclusions
About one in five participants reported challenges accessing HIV care, medications, or services, and they faced complex, multilayered barriers to remaining engaged. Physical health, mental health, relationships with partners, and ability to care for their infant were also affected. Given the dynamic nature of the pandemic and general uncertainty about its course, ongoing assessment of pandemic-related challenges among postpartum women is needed to avoid HIV care disruptions and to support wellbeing.
The analgesic effect of total intravenous anaesthesia with propofol versus inhalational anaesthesia for acute postoperative pain after hepatectomy: a randomized controlled trial
Authors: Wong Sau-ching Stanley , Wang Fengfeng , Chan Chi Wing Timmy , Cheung Chi Wai 
Published: January 2023

Abstract

Background Postoperative pain control can be challenging in patients undergoing hepatectomy. A previous retrospective study on hepatobiliary/ pancreatic surgeries showed better postoperative pain control in patients who received propofol TIVA. The aim of this study was to determine the analgesic effect of propofol TIVA for hepatectomy. This clinical study has been registered at ClinicalTrials.gov (NCT03597997). Methods A prospective randomized controlled trial was performed to compare the analgesic effect of propofol TIVA versus inhalational anaesthesia. Patients aged between 18 and 80 years old with an American Society of Anesthesiologist (ASA) physical status of I-III scheduled for elective hepatectomy were recruited. Ninety patients were randomly allocated to receive either propofol TIVA (TIVA group) or inhalational anaesthesia with sevoflurane (SEVO group). Perioperative anaesthetic/analgesic management was the same for both groups. Numerical rating scale (NRS) pain scores, postoperative morphine consumption, quality of recovery, patient satisfaction and adverse effects were evaluated during the acute postoperative period and at 3 and 6 months after surgery. Results No significant differences were found for acute postoperative pain scores (both at rest and during coughing) and postoperative morphine consumption between TIVA and SEVO groups. Patients given TIVA had lower pain scores with coughing at 3 months after surgery (p = 0.014, and FDR < 0.1). TIVA group was associated with better quality of recovery on postoperative day (POD) 3 (p = 0.038, and FDR < 0.1), less nausea (p = 0.011, and FDR < 0.1 on POD 2; p = 0.013, and FDR < 0.1 on POD 3) and constipation (p = 0.013, and FDR < 0.1 on POD 3). Conclusion Propofol TIVA did not improve acute postoperative pain control compared to inhalational anaesthesia in patients who underwent hepatectomy. Our results do not support the use of propofol TIVA for reducing acute postoperative pain after hepatectomy.
The first report of co-infection with Sphaerirostris picae and Ascaridia galli in the Oriental magpie (Pica serica) in Beijing, China
Authors: Hu Bin , Wang Jiamin , Wang Ye , Li Yi , wang Bo , Xiang Chen , Xing Yanan , Han shuyi , Yuan Guohui , He Hongxuan 
Published: January 2023

Abstract
Background
As a wild bird adapted to urban pressures, the Oriental Magpie (Pica serica) can carry a variety of pathogenic microorganisms that affect public health and safety. Sphaerirostris picae and Ascaridia galli can be parasitic in the digestive tract of wild birds and are transmitted between hosts. In this study, we identified nematode species in the intestinal tract of Oriental magpie in Beijing, China, revealing the health threats posed by parasitic worms to urban birds and the potential public health risks posed to humans and other animals.
Results
Sphaerirostris picae and Ascaridia galli isolated from the intestinal tract of Oriental magpie in Beijing. Morphological characteristics of the parasites were observed by stereoscopic microscope and scanning electron microscope, and phylogenetic relationships of the parasites were analyzed by sequencing the COX1 gene.
Conclusions
To our knowledge, this is the first study to show the presence of Sphaerirostris picae infection in magpies in China and the first report of co-infection of the two parasites in wild birds, confirming the epidemiological role of urban birds in public health.
Screening transcription factors of IbMYB1-4 by yeast one-hybrid assays in purple-fleshed sweet potato
Authors: Fu Danwen , Yang Shaohua , Liu Rui , Gao Feng 
Published: January 2023

Abstract
The transcription factor IbMYB1 has been identified to be involved in anthocyanin biosynthesis in purple-fleshed sweet potato. However, the upstream transcription factors of PIbMYB1-4 involved in anthocyanin biosynthesis have rarely been studied. In this study, yeast one-hybrid screen was conducted in purple-fleshed sweet potato storage roots to identify upstream transcription factors of PIbMYB1-4. Three proteins, IbERF1, IbPGP19 and IbPDC, were screened as the upstream binding proteins of PIbMYB1-4. Yeast one-hybrid assays and luciferase reporter assays were used to verify that upstream binding proteins interacted with the promoters. The interaction between the promoters and upstream binding proteins was verified by yeast one-hybrid and luciferase reporter assays. The gene expression of upstream transcription factors, transcription factors and structural genes involved in anthocyanin biosynthesis in different root stages of purple-fleshed and white-fleshed sweet potato was analyzed by real-time PCR. IbERF1 has been identified as the upstream transcription factor of PIbMYB1 involved in anthocyanin biosynthesis in purple-fleshed sweet potato. It has been identified that IbERF1 plays an important role in anthocyanin biosynthesis in purple-fleshed sweet potato.
Federated learning for feature-fusion based requirement classification
Authors: wang Ruiwen , Liu Jihong 
Published: January 2023

Abstract

With the increasing complexity of products, the utilization of automated requirements classification in the process of requirement engineering is of positive significance to improve the efficiency of product development. There have been many experiments on the requirements classification based on artificial intelligence. However, many studies only use a single feature in semantic features or statistical features to classify requirements and put forward the problem of small-scale requirement datasets caused by the confidentiality of requirement data, which limits the application research of requirement classification in a large number of fields. Therefore, we propose a requirement classification model that integrates semantic and statistical features, and design a federated learning framework based on knowledge distillation without centralized servers in a ring architecture. In this paper, we extract a large amount of requirement data from a large number of requirement documents, and conduct experiments in the centralized learning environment and the federated learning environment respectively. The final experimental results show that our method can maintain the confidentiality of the requirement data and improve the communication efficiency in the process of model training with a slight decrease in the effect of requirement classification compared with centralized learning.
Predominant Antibody Deficiency and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden
Authors: DiGiacomo Daniel V , Roelstraete Bjorn , Hammarström Lennart , Farmer Jocelyn R , Khalili Hamed , Ludvigsson Jonas F. 
Published: January 2023

Abstract
Purpose
Predominant antibody deficiency (PAD) disorders, including common variable immunodeficiency (CVID), have been linked to increased risk of gastrointestinal infections and inflammatory bowel diseases. However, there are limited data on the relationship between PAD, specifically CVID, and risk of microscopic colitis (MC).
Methods
We performed a nationwide case-control study of Swedish adults with MC diagnosed between 1997 and 2017 (n = 13,651). Data on biopsy-verified MC were retrieved from Sweden’s all 28-pathology departments through the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) study. We defined predominant antibody deficiency using International Union of Immunologic Societies (IUIS) phenotypic classification. Individuals with MC were matched to population controls by age, sex, calendar year, and county. We used logistic regression to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).
Results
The prevalence of PAD in MC was 0.4% as compared to 0.05% in controls. After adjustment for potential confounders, this corresponded to an aOR of 7.29 (95%CI 4.64–11.63). The magnitude of the association was higher for CVID (aOR 21.01, 95% 5.48-137.44) compared to other antibody deficiencies (aOR 6.16, 95% CI 3.79–10.14). In exploratory analyses, the association between PAD and MC was particularly strong among males (aOR 31.73, 95% CI 10.82-135.04).
Conclusion
In this population-based study, predominant antibody deficiency was associated with increased risk of MC, particularly among males. Clinicians who encounter these patients should consider a detailed infectious history and screening for antibody deficiency.
Development and Evaluation of a Predictive Diagnostic System for Dengue Fever using Machine Learning Techniques
Authors: Khan Jibran Rasheed , Farooqui Sehan Ahmed , Raza Syed Kawish , Siddiqui Farhan Ahmed 
Published: January 2023

Abstract
As the world continues to evolve scientifically and climatically, the medical and healthcare sectors face new challenges in the form of newly identified diseases, insects, chemicals, and environmental effects. These new challenges are often more complex and dangerous than existing conditions, and require prompt diagnosis and appropriate treatment to prevent loss of life. This paper presents a study on the development of a presumptive diagnosis system (PDS) for early dengue fever detection. The proposed system aims to assist medical professionals in determining the disease at an early stage and help unprofessional or new staff to learn and experiment better. The PDS utilizes machine learning algorithms such as Decision Tree (DT), Random Forest (RF), and Naive Bayes (NB), along with their combination, to classify dengue fever and its types. The dataset used in this study consisted of 400 records of 15 attributes, and the data was preprocessed to reduce noise, incompleteness and inconsistencies. The classification results showed that the PDS achieved an average accuracy of 95.6%, with the highest individual accuracy achieved by RF, DT and NB being 98%, 97% and 87% respectively. Our results demonstrate that PDS can facilitate the diagnostic process in resource-limited settings by providing an alternative to hardware-intensive solutions. Furthermore, the system can aid healthcare professionals in making early and accurate diagnoses, and can also serve as a learning tool for new staff.