bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of postmortem imaging modalities in cases of sudden death due to cardiovascular diseases–current achievements and limitations from a pathology perspective
Authors: Michaud Katarzyna , Jacobsen Christina , Basso Cristina , Banner Jytte , Blokker Britt M. , de Boer Hans H. , Dedouit Fabrice , O’Donnell Chris , Giordano Carla , Magnin Virginie , Grabherr Silke , Suvarna S. Kim , Wozniak Krzysztof , Parsons Sarah , van der Wal Allard C. 
Published: December 2022

Abstract
Postmortem imaging (PMI) is increasingly used in postmortem practice and is considered a potential alternative to a conventional autopsy, particularly in case of sudden cardiac deaths (SCD). In 2017, the Association for European Cardiovascular Pathology (AECVP) published guidelines on how to perform an autopsy in such cases, which is still considered the gold standard, but the diagnostic value of PMI herein was not analyzed in detail. At present, significant progress has been made in the PMI diagnosis of acute ischemic heart disease, the most important cause of SCD, while the introduction of postmortem CT angiography (PMCTA) has improved the visualization of several parameters of coronary artery pathology that can support a diagnosis of SCD. Postmortem magnetic resonance (PMMR) allows the detection of acute myocardial injury-related edema. However, PMI has limitations when compared to clinical imaging, which severely impacts the postmortem diagnosis of myocardial injuries (ischemic versus non-ischemic), the age-dating of coronary occlusion (acute versus old), other potentially SCD-related cardiac lesions (e.g., the distinctive morphologies of cardiomyopathies), aortic diseases underlying dissection or rupture, or pulmonary embolism. In these instances, PMI cannot replace a histopathological examination for a final diagnosis. Emerging minimally invasive techniques at PMI such as image-guided biopsies of the myocardium or the aorta, provide promising results that warrant further investigations. The rapid developments in the field of postmortem imaging imply that the diagnosis of sudden death due to cardiovascular diseases will soon require detailed knowledge of both postmortem radiology and of pathology.
High-dose chemotherapy and autologous stem cell transplantation in primary lymphomatoid granulomatosis of the central nervous system
Authors: Nilius-Eliliwi Verena , Treiber Hannes , Seidel Sabine , Vangala Deepak B. , Schroers Roland 
Published: December 2022

AbstractPrimary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein–Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.
Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?
Authors: Drougkas Konstantinos , Karampinos Konstantinos , Karavolias Ioannis , Koumprentziotis Ioannis-Alexios , Ploumaki Ioanna , Triantafyllou Efthymios , Trontzas Ioannis , Kotteas Elias 
Published: December 2022

Abstract
Introduction
Chimeric Antigen Receptor (CAR)-T cell therapy is a form of adoptive cell therapy that has demonstrated tremendous results in the treatment of hematopoietic malignancies, leading to the US Food and Drug Administration (FDA) approval of four CD19-targeted CAR-T cell products. With the unprecedented success of CAR-T cell therapy in hematological malignancies, hundreds of preclinical studies and clinical trials are currently undergoing to explore the translation of this treatment to solid tumors. However, the clinical experience in non-hematologic malignancies has been less encouraging, with only a few patients achieving complete responses. Tumor-associated antigen heterogeneity, inefficient CAR-T cell trafficking and the immunosuppressive tumor microenvironment are considered as the most pivotal roadblocks in solid tumor CAR-T cell therapy.

Materials and methods
We reviewed the relevant literature/clinical trials for CAR-T cell immunotherapy for solid tumors from Pubmed and ClinicalTrials.gov.

Conclusion
Herein, we provide an update on solid tumor CAR-T cell clinical trials, focusing on the studies with published results. We further discuss some of the key hurdles that CAR-T cell therapy is encountering for solid tumor treatment as well as the strategies that are exploited to overcome these obstacles.
Temporal variation in the depth of the magma surface at Aso volcano in 2014–2015
Authors: Ishii Kyoka , Yokoo Akihiko , Ohkura Takahiro , Kazama Takahito 
Published: December 2022

AbstractMonitoring the depth of the magma surface at open-vent volcanoes can be a practical tool to infer temporal variations in the magma supply during an eruption. We focus on the magmatic eruption of Aso volcano in 2014–2015 to estimate the temporal change in the depth of the magma surface, and show that this needs to be coupled with an understanding of the shallow conduit geometry if it is to be done in a representative manner. The eruption lasted 5 months from November 2014 and ending with a crater floor collapse in May 2015. During the eruption, we recorded seismo-acoustic waveforms related to frequent Strombolian explosions. The infrasound signals show several distinct peak frequencies derived from acoustic resonance inside the vent. We estimate the depth of the magma surface using the time delay of seismo-acoustic signals and the peak frequency of infrasound signals. In addition, the temporal variation in the shape of the conduit is constrained by the overtone frequency of the acoustic resonance. From the beginning of the eruption to early-January 2015, the magma surface was located at a depth of $\sim $
∼
200 m, and the conduit was a cylindrical pipe. Later, between January and February, the magma surface rose to $\sim $
∼
120 m, and the shape of the conduit changed to a conical frustum flaring inside. This finding indicates that the magma was injected into the shallow conduit and that it heated and weakened the conduit wall near the magma surface. Before the cessation of the magmatic eruption, the magma surface dropped by approximately 70 m. This magma drainage and, primarily, the instability of the conduit shape caused the crater floor to collapse. We show the possibility of tracking and assessing the depth of the magma surface and the shallow conduit geometry even with limited seismo-acoustic observations.
Space-time integral currents of bounded variation
Authors: Rindler Filip 
Published: December 2022

AbstractMotivated by a recent model for elasto-plastic evolutions that are driven by the flow of dislocations, this work develops a theory of space-time integral currents with bounded variation in time, which enables a natural variational approach to the analysis of rate-independent geometric evolutions. Based on this, we further introduce the notion of Lipschitz deformation distance between integral currents, which arises physically as a (simplified) dissipation distance. Several results are obtained: A Helly-type compactness theorem, a deformation theorem, an isoperimetric inequality, and the equivalence of the convergence in deformation distance with the classical notion of weak* (or flat) convergence. Finally, we prove that the Lipschitz deformation distance agrees with the (integral) homogeneous Whitney flat metric for boundaryless currents. Physically, this means that two seemingly different ways to measure the dissipation actually coincide.
Finite time blow up and concentration phenomena for a solution to drift-diffusion equations in higher dimensions
Authors: Ogawa Takayoshi , Suguro Takeshi , Wakui Hiroshi 
Published: December 2022

AbstractWe show the finite time blow up of a solution to the Cauchy problem of a drift-diffusion equation of a parabolic-elliptic type in higher space dimensions. If the initial data satisfies a certain condition involving the entropy functional, then the corresponding solution to the equation does not exist globally in time and blows up in a finite time for the scaling critical space. Besides there exists a concentration point such that the solution exhibits the concentration in the critical norm. This type of blow up was observed in the scaling critical two dimensions. The proof is based on the profile decomposition and the Shannon inequality in the weighted space.
Bootstrapping globally optimal variational calculus solutions
Authors: Chirikjian Gregory S. 
Published: December 2022

AbstractWhereas in a coordinate-dependent setting the Euler–Lagrange equations establish necessary conditions for solving variational problems in which both the integrands of functionals and the resulting paths are assumed to be sufficiently smooth, uniqueness and global optimality are generally hard to prove in the absence of convexity conditions, and often times they may not even exist. This is also true for variational problems on Lie groups, with the Euler–Poincaré equation establishing necessary conditions. The difficulties compound when integrands and/or the optimal paths are not sufficiently regular, since in this case the classical necessary conditions no longer apply. This article therefore reviews several nonstandard cases where unique globally optimal solutions can be guaranteed, and establishes a “bootstrapping” process to build new globally optimal variational solutions on larger spaces from existing ones on smaller spaces. Surprisingly, it is possible to prove global optimality in some nonconvex cases where even the regularity conditions required for classical necessary conditions do not hold. This general theory is then applied to several topics such as optimal framing of curves in three-dimensional Euclidean space, optimal motion interpolation, and optimal reparametrization of video sequences to compare salient actions.
Caregiving and mental health needs in the significant others of women receiving inpatient and home treatment for acute severe postpartum mental illness
Authors: Atmore Katie H. , Taylor Billie Lever , Potts Laura C. , Trevillion Kylee , Howard Louise M. 
Published: December 2022

AbstractTo examine the mental health and caregiving needs of significant others (including partners, parents, friends) to women who received acute psychiatric care either as inpatients or at home during the perinatal period. Cross-sectional survey of 98 significant others of 279 women who participated in a quasi-experimental cohort study of services for mothers with acute severe postpartum mental health diagnoses. Significant others completed an adapted General Health Questionnaire-12 (GHQ) and Involvement Evaluation Questionnaire (IEQ) to indicate their mental health needs and service use as well as caregiving activities. The mean age of significant others was 38.9 years (range 24–69). 81.6% were male and 81.6% were intimate partners to the women. High levels of unmet mental health needs were detected in significant others, with a majority (51.0%) having a score > 2 on the GHQ-12 indicating caseness for a psychiatric disorder. In those with GHQ-12 caseness indicated, few were receiving help for their difficulties: 22.5% received support from their general practitioner, and 14.3% received help from a social worker, psychologist, psychiatrist or outpatient department. 18.4% received medication for GHQ-12 symptoms. The median sumscore of IEQ surveying caregiving activities in significant others was 18/108. We did not find evidence of differences in GHQ-12 or IEQ scores for significant others to women who received inpatient care versus care at home. Significant others to women with acute severe postpartum psychiatric illness have high levels of unmet mental health needs during the weeks after women are discharged from acute care. Services need to address these needs to optimise outcomes for the whole family.
Effects of customized CAD/CAM abutments on cytokine levels in peri-implant crevicular fluid during early implant healing: a pilot study
Authors: Wehner Christian , Fürst Gabor , Vaskovich Tom , Andrukhov Oleh , Vasak Christoph , Moritz Andreas , Rausch-Fan Xiaohui 
Published: December 2022

Abstract

Objectives
This study aimed to assess levels of biomarkers associated with inflammation and tissue destruction in peri-implant crevicular fluid (PICF) of implants provided with customized or standard healing abutments during early implant healing.

Materials and methods
Thirty implants were placed in 22 patients with partial posterior edentulism. Subsequently, test group implants (n=15) received one-piece titanium abutments that were fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM). Control group implants (n=15) were provided with standard abutments. PICF collection and standardized periapical radiographs were carried out at suture removal one week later, following crown delivery after 3 months and at 6 months. Expression of C-reactive protein (CRP), interferon-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12A, IL-17A, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase (MMP)-13, osteopontin, osteoactivin, Receptor Activator of NF-κB (RANK), and TGF-β were analyzed using a multiplex ELISA kit.

Results
Both groups showed a significant decrease in protein expression of CRP, IL-1β, IL-6, IL-8, MIP-1α, osteopontin, osteoactivin, and TGF-β, while MMP-13 levels increased during the observation period. A rise in OPG and RANK levels was detected among customized abutments. Expression of CRP was higher, whereas IL-1β, IL-1α, and MIP-1α were decreased in control compared to test group implants after 6 months. Marginal bone loss did not depend on abutment modality.

Conclusions
Both abutment types showed distinctive temporal expression of inflammatory biomarkers during 6 months following implant placement.

Trial registration
ISRCTN98477184, registration date 18/05/2022

Clinical relevance
Customized healing abutments exert similar effects on inflammation during early implant healing compared to standard healing abutments.
HLA-B27 as a predictor of effectiveness of treatment with TNF inhibitors in axial spondyloarthritis: data from the Swiss Clinical Quality Management Registry
Authors: Fröhlich Fabienne , Micheroli Raphael , Hebeisen Monika , Kissling Seraphina , Bürki Kristina , Exer Pascale , Bräm René , Niedermann Karin , Möller Burkhard , Nissen Michael J. , Kyburz Diego , Andor Michael , Distler Oliver , Scherer Almut , Ciurea Adrian 
Published: December 2022

Abstract
Objective
To explore the impact of the human leucocyte antigen (HLA)-B27 on the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA).

Methods
A total of 1109 patients with available HLA-B27 status (831 B27+ patients and 278 B27− patients) fulfilling the Assessment of Spondyloarthritis international Society classification criteria for axSpA from the prospective Swiss Clinical Quality Management Registry initiating a first TNFi were included. Drug retention was investigated with multiple adjusted Cox proportional hazard models with imputation of missing values. Multiple-adjusted logistic regression analyses were used to assess the proportion of patients reaching 50% reduction in the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI50) at 1 year.

Results
B27+ and B27− patients differed with regard to age, sex, BASDAI, C-reactive protein (CRP), body mass index, enthesitis, uveitis, and classification status. After adjustment for potential confounders for the relationship between HLA-B27 and drug effectiveness (sex and family history of spondyloarthritis), a higher risk of drug discontinuation was found in B27− patients (HR 1.53, 95% CI 1.27–1.83). This difference decreased after additional adjustment for parameters which may act as mediators (HR 1.30, 95% CI 1.30–1.55). Male sex and elevated C-reactive protein (CRP) levels were consistently associated with longer retention. Comparable results were obtained for BASDAI50 responses.

Conclusion
The HLA-B27 genotype is an important predictor of treatment effectiveness. Male sex and CRP seem, however, to better describe variability of response in individual patients. This data may help avoiding potential discrimination of B27− individuals with regard to TNFi initiation.

Key Points• HLA-B27 is a predictor of effectiveness of TNF inhibitors in axial spondyloarthritis.• Variability of response in individual patients is better defined by sex and objective markers of disease activity, such as C-reactive protein.
Basilar artery curvature increases the risk of posterior circulation infarction occurrence in patients without vertebrobasilar stenosis
Authors: Cao Shugang , Zhai Mingfeng , He Jun , Wang Jian , Ge Tingting , Wu Qian , Ni Xiaoxing , Cui Ping , Xu Wen’an , Xia Mingwu 
Published: December 2022

Abstract
Introduction

Limited cross-sectional or case–control studies have identified the relationship between basilar artery (BA) curvature and posterior circulation infarction (PCI). This study aimed to identify the influence of BA curvature severity on the risk of PCI occurrence in patients without vertebrobasilar stenosis through a prospective cohort study.

Methods
In this study, we enrolled 171 patients with BA dolichosis but without vertebrobasilar stenosis. The BA geometric parameters were evaluated on MRA. The primary outcome was the occurrence of PCI, mainly referring to cerebellar and/or brainstem infarction. Cox proportional hazard models were used to detect possible predictors of PCI.

Results
Among them, 134 (78.4%) patients were diagnosed with BA curvature, including 124 with moderate curvature and 10 with prominent curvature. The defined PCI occurrence was observed in 32 (18.7%) patients with a median follow-up time of 45.6 months. Cox proportional hazard analysis showed that BA prominent curvature (HR = 6.09; 95% CI: 1.36–27.28; P = 0.018) significantly increased the risk of PCI occurrence, and bending length (BL) was also significantly associated with PCI occurrence, with the adjusted HR per 1-mm increase of BL of 1.09 (95% CI: 1.01–1.18; P = 0.040). In the subgroup analysis stratified by age, BA prominent curvature was highly associated with PCI occurrence in patients aged > 61 years (HR = 11.76; 95% CI: 1.21–113.90; P = 0.033). Additionally, good antiplatelet therapy adherence could significantly reduce the risk of PCI occurrence.

Conclusion
BA curvature may increase the risk of PCI occurrence, especially in elderly patients with prominent curvature. Improving adherence to antiplatelet therapy can help reduce the risk of PCI occurrence.
A combined subcision approach with either fractional CO2 laser (10,600 nm) or cross-linked hyaluronic acid versus subcision alone in atrophic post-acne scar treatment
Authors: Abdelwahab Alaa Abdelaziz , Omar Ghada Abdel badea , Hamdino Mervat 
Published: December 2022

AbstractDifferent treatment options for post-acne scars exist, but with varying clinical efficacy, side effects, and prolonged downtime. This study aims to compare the efficacy and safety of combined subcision with either fractional CO2 laser or cross-linked hyaluronic acid filler (HA) versus subcision alone in the treatment of facial atrophic post-acne scars. Forty patients with atrophic post-acne scars were subjected to subcision on both sides of the face, then were randomly divided into three groups. Group I (20 patients): subcision combined with cross-linked HA filler injection at one side of the face; group II (20 patients): subcision followed by fractional CO2 at the other side of the face; and group III (20 patients): with subcision only as a control group. Treatment sessions were every month until clinical improvement or for maximum three sessions. The treatment’s efficacy was assessed by Goodman and Baron’s qualitative and quantitative grading systems. The two blinded investigator scores showed significant improvement in both the filler side versus subcision (p value = 0.015), and the fractional laser side versus subcision (p value < 0.001), with no statistically significant difference between both sides (p value = 0.171). Qualitative grading by Goodman and Baron scores showed that the percentage of patients with excellent improvement was higher in group 1 and group 2 than in group 3 with p value = 0.031; also the mean percentage of reduction in quantitative grading was higher in group 1 and group 2 than in group 3 with p value < 0.00. Either combined subcision with fractional CO2 laser or with cross-linked HA filler achieved superior improvement in facial atrophic post acne scars treatment with no serious side effects in this study. However, subcision only by blunt canula also had modest improvement.
Validation of the Berlin Grading System for moyamoya angiopathy with the use of [15O]H2O PET
Authors: Mertens R. , Acker G. , Kersting K. , Lange C. , Furth C. , Beyaztas D. , Truckenmueller P. , Moedl L. , Spruenken E. D. , Czabanka M. , Vajkoczy P. 
Published: December 2022

Abstract
The Berlin Grading System assesses clinical severity of moyamoya angiopathy (MMA) by combining MRI, DSA, and cerebrovascular reserve capacity (CVRC). Our aim was to validate this grading system using [15O]H2O PET for CVRC. We retrospectively identified bilateral MMA patients who underwent [15O]H2O PET examination and were treated surgically at our department. Each hemisphere was classified using the Suzuki and Berlin Grading System. Preoperative symptoms and perioperative ischemias were collected, and a logistic regression analysis was performed. A total of 100 hemispheres in 50 MMA patients (36 women, 14 men) were included. Using the Berlin Grading System, 2 (2.8%) of 71 symptomatic hemispheres were categorized as grade I, 14 (19.7%) as grade II, and 55 (77.5%) as grade III. The 29 asymptomatic hemispheres were characterized as grade I in 7 (24.1%) hemispheres, grade II in 12 (41.4%), and grade III in 10 (34.5%) hemispheres. Berlin grades were independent factors for identifying hemispheres as symptomatic and higher grades correlated with increasing proportion of symptomatic hemispheres (p < 0.01). The Suzuki grading did not correlate with preoperative symptoms (p = 0.26). Perioperative ischemic complications occurred in 8 of 88 operated hemispheres. Overall, complications did not occur in any of the grade I hemispheres, but in 9.1% (n = 2 of 22) and 9.8% (n = 6 of 61) of grade II and III hemispheres, respectively. In this study, we validated the Berlin Grading System with the use of [15O]H2O PET for CVRC as it could stratify preoperative symptomatology. Furthermore, we highlighted its relevance for predicting perioperative ischemic complications.