bluuebunny/crossref_metadata_2025_split huggingface dataset:
How does investor attention affect energy firms' managerial opportunistic behavior? New evidence from China
Authors: Cao Wei , Linnenluecke Martina , Tian Jinfang , Xue Rui , Yang Huan 
Published: March 2023

AbstractThe energy sector plays a crucial role in facilitating the low‐carbon energy transition. However, in the absence of appropriate environmental regulation, managerial opportunistic behavior in energy firms can manipulate ethical investor perceptions and hinder the real transition process towards clean energy. Using Chinese listed energy firms as the research setting, this paper examines the impact of investor attention on energy firms' earnings management practices. In both clean and traditional energy firms, the results show a significant U‐shaped association between investor attention and earnings management, with the U‐shaped curve for clean energy firms being smoother. This U‐shaped relationship is more pronounced in energy firms with larger size and weaker external monitoring. Moreover, the mediating analysis shows that internal control quality transmits the impact of investor attention onto earnings management practices in the energy sector. Our key findings remain robust to a battery of robustness tests and endogeneity controls. Therefore, given the growing attention on the energy sector, this study extends the existing literature on energy firms' managerial opportunistic behavior by analyzing the nonlinear effect for investor attention and provides practical implications for curbing energy firms' managerial opportunistic activities and guiding managerial attention towards making real sustainable investments, thereby promoting clean energy transition and sustainable development.
Prognostic value of cross‐lineage expression of the myeloid‐associated antigens CD13 and CD33 in adult B‐lymphoblastic leukemia: A large real‐world study of 1005 patients
Authors: Liao Hongyan , Lai Hongli , Chen Jiao , Shuai Xiao , Zhang Xin , Yang Ying , Lyu Mengyuan , Zheng Qin 
Published: March 2023

AbstractBackgroundCross‐lineage expression of the myeloid‐associated antigens CD13/CD33 is common in adult B‐lymphoblastic leukemia (B‐ALL) patients, yet its prognostic value is still controversial.MethodsWe conducted a retrospective study of 1005 de novo adult B‐ALL patients from January 2009 to December 2019 in our hospital. Logistic and Cox regression were used to analyze the prognostic value of CD13/CD33 expression in B‐ALL. A Cox regression model was established to predict overall survival (OS) for B‐ALL patients.ResultsOf the 1005 B‐ALL patients, 53.7% (n = 540) aberrantly expressed CD13/CD33 (CD13/CD33+). Patients in the CD13/CD33+ group showed a higher incidence of BCR::ABL1 rearrangement and minimal/measurable residual disease (MRD) positivity but similar complete remission rate, relapse‐free survival, mortality, and OS with CD13/CD33‐. CD13/CD33+ patients had a higher risk of MRD positivity than CD13/CD33‐ patients. Notably, CD13/CD33+ patients who underwent tyrosine kinase inhibitor (TKI) therapy had a better long‐term prognosis than those without TKI experience. Sex, group based on CD13/CD33 expression and TKI experience and white blood cell count were variables independently associated with OS. The Cox regression model integrating these three variables showed a moderate performance for OS prediction (C‐index: 0.724).ConclusionsIn real‐world practice, CD13/CD33 expression can predict the risk of MRD in patients without TKI experience, but has no adverse effect on the prognosis of adult B‐ALL patients. Incorporating CD13/CD33 into the standard antibody panels of B‐ALL diagnosis and MRD measurements can help predict relapse risk and decisions on therapy options.
Efficacy and toxicity profile of first‐line treatment for extensive‐stage small cell lung cancer: A Bayesian network meta‐analysis
Authors: Lin Guo , Yao Zhuoran , Kang Kai , Wang Hui , Luo Ren , Lu You 
Published: March 2023

AbstractBackgroundThe efficacy and toxicity profiles for extensive‐stage small cell lung cancer (ES‐SCLC) are unclear. We aimed to address this gap through a Bayesian network meta‐analysis.MethodsWe performed network analysis from randomized controlled trials comparing these treatments: PD‐(L)1 inhibitor, CTLA‐4 inhibitor, CXCR inhibitor, PARP inhibitor, CDK inhibitor, chemotherapy, and their combinations. Pooled estimations of progression‐free survival, overall survival, objective response rate, and toxicity (systematic and specific) were conducted within the Bayesian framework.ResultsTwenty‐five trials involving 9 strategies were included. In terms of progression‐free survival and overall survival, PD‐(L)1 inhibitor combined with cisplatin/carboplatin (P) and etoposide (E) shown the acknowledged superiority than other treatments. The addition of CTLA‐4 inhibitor (ipilimumab) to EP had the highest response rate among these regimens, and the combination of chemotherapy (irinotecan) and cisplatin/carboplatin had the greatest probability of performing considerable systematic security. The secondary endpoint was specific adverse events, including vomiting, fatigue, thrombocytopenia, constipation, and decreased appetite; hence we depicted the specific toxicity profile of each regimen. In addition, we identified the differences between PD‐1 inhibitors and PD‐L1 inhibitors in prolonging overall survival time for the central nervous system (CNS)/liver metastases patients.ConclusionsEP combined with PD‐(L)1 inhibitor followed by CTLA‐4 inhibitors or anti‐angiogenesis was the considerable treatment with considerable efficacy and safety for ES‐SCLC. Each treatment has a unique specific toxicity profile, which needs more attention.
Effectiveness and safety of immune checkpoint inhibitor monotherapy in advanced upper tract urothelial carcinoma: A multicenter, retrospective, real‐world study
Authors: Su Ruopeng , Chen Zeyu , Hong Daoping , Jiang Shuai , Yuan Yichu , Cai Xingyun , Hu Hailong , Fu Changde , Huang Zhiyang , Wang Zhenyu , Zheng Bing , Huang Jian , Wang Zaoyu , Bao Yige , Cai Ming , Guo Jianming , Chen Minfeng , Wei Qiang , Huang Jiwei , Xue Wei 
Published: March 2023

AbstractIntroductionThe effectiveness and safety of immune checkpoint inhibitor (ICI) monotherapy in advanced upper tract urothelial carcinoma (UTUC) is less reported.MethodsIn total, 106 consecutive advanced UTUC patients receiving ICI monotherapy were collected from nine high volume centers. Clinical outcomes were analyzed according to multiple parameters (e.g., treatment line, metastatic sites). Objective response rate (ORR), overall survival (OS) and progression‐free survival (PFS) were captured after ICI initiation.ResultsWith a median follow‐up of 12.0 months, 25 patients in the first‐line group and 15 patients in the second‐line group died of UTUC. We reported a median OS of 18.0 months, a median PFS of 5.0 months, and an ORR of 38.6% for patients in the first‐line group; a median OS of 10.0 months, a median OS of 4.0 months, and an ORR of 27.8% for patients in the second‐line group. Complete response was observed in two patients in the first‐line group and one patient in the second‐line group with a total complete response rate of 2.8%. In the univariate and multivariate analysis, visceral metastasis with a hazard ratio of 2.4 was associate with poor OS. The most common treatment‐related adverse events included fatigue (11.3%), pruritus (10.4%), and diarrhea (6.6%).ConclusionsThis real‐world study suggests that ICI monotherapy is active and has acceptable toxic effects for unresectable or metastatic UTUC as first‐line therapy in cisplatin‐ineligible patients or second‐line therapy in platinum‐refractory patients.
Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration
Authors: Nong Ju‐sen , Zhou Xin , Liu Jun‐qi , Luo Jian‐zhu , Huang Jia‐mi , Xie Hai‐xiang , Yang Ke‐jian , Wang Jing , Ye Xin‐ping , Peng Tao 
Published: March 2023

AbstractObjectiveTo assess the diagnostic value and clinical significance of nucleoporin 107 (NUP107) in hepatocellular carcinoma (HCC), and explore the possible mechanisms.MethodsThe transcriptomic and clinical data of HCC patients were retrieved from The Cancer Genome Atlas (TCGA) and GEO databases. Tissue specimens were collected from HCC patients in the Guangxi area. According to the expression levels and prognostic characteristics of NUP107, ROC curves and nomogram models were constructed using the R package.ResultsNUP107 was highly expressed in 26 human cancers including HCC, and was associated with advanced HCC staging and worse prognosis. NUP107 showed satisfactory ability to predict the prognosis of HCC patients (AUC >0.8). Results of gene set enrichment analysis (GSEA) further showed that NUP107 was mainly associated with cell cycle‐related pathways such as the cell cycle, DNA replication, G2M checkpoint, E2F target, and mitotic spindle. In addition, NUP107 was also associated with immune infiltration in HCC and showed significant positive correlation with immune checkpoints (PD‐L1 and TIM‐3).
Impact of skeletal muscle volume on patients with BCLC stage‐B hepatocellular carcinoma undergoing sorafenib therapy
Authors: Saeki Issei , Yamasaki Takahiro , Yamauchi Yurika , Kawaoka Tomokazu , Uchikawa Shinsuke , Hiramatsu Akira , Aikata Hiroshi , Kobayashi Kazufumi , Kondo Takayuki , Ogasawara Sadahisa , Chiba Tetsuhiro , Kawano Reo , Chayama Kazuaki , Kato Naoya , Takami Taro 
Published: March 2023

AbstractAimSkeletal muscle volume has been reported to be an important factor that determines overall survival (OS) and post‐progression survival (PPS) in patients with hepatocellular carcinoma (HCC). However, the impact of skeletal muscle volume on HCC with Barcelona Clinic Liver Cancer (BCLC) stage B (BCLC‐B) remains unclear. We conducted sub‐analyses of a previous study on BCLC‐B and compared our findings with data on HCC with BCLC stage C (BCLC‐C).MethodsWe retrospectively enrolled 356 patients with HCC (BCLC‐B, n = 78; and BCLC‐C, n = 278) undergoing sorafenib therapy. Prognostic factors were analyzed using various parameters, including skeletal muscle volume. Muscle volume (MV) depletion was designated as less than the median value of the skeletal muscle index for each gender (cutoff value: 45.0 cm2/m2 for male and 38.0 cm2/m2 for female participants).ResultsBoth OS and PPS showed no significant differences in patients with non‐MV depletion and those with MV depletion in the BCLC‐B group (Median OS [MST] 19.3 vs. 13.5 months [p = 0.348]; median PPS 9.7 vs. 10.8 months [p = 0.578]). In the BCLC‐C group, patients with non‐MV depletion had a significantly longer OS and PPS compared to patients with MV depletion (MST 12.4 vs. 9.0 months [p = 0.001] and median PPS 7.9 vs. 5.4 months [p = 0.002]). Multivariate analysis revealed that MV depletion was an independent prognostic factor of OS and PPS in the BCLC‐C group but not in the BCLC‐B group.ConclusionsSkeletal muscle volume showed little impact on the clinical outcomes of patients with BCLC‐B undergoing sorafenib therapy.
Linguistic analysis of plain language summaries and corresponding scientific summaries of Cochrane systematic reviews about oncology interventions
Authors: Šuto Jelena , Marušić Ana , Buljan Ivan 
Published: March 2023

AbstractBackgroundCochrane plain language summaries (PLSs) are an important format to present high‐quality healthcare evidence to patients with cancer and their families. They should be written in a way everyone can understand, since they serve as a tool in decision‐making and present a bridge to overcome the gap between the healthcare users and professionals.ObjectiveThe aim of the study was to assess the language characteristics of PLSs of Cochrane systematic reviews of oncology interventions in comparison with corresponding Cochrane scientific abstracts (SAs).MethodsIn this cross‐sectional study, we included all Cochrane PLSs and SAs of systematic reviews of oncology interventions available in the Cochrane Database of Systematic Reviews. We assessed text readability, measured using the Simple Measure of Gobbledygook (SMOG) index, and the prevalence of words related to different language tones (clout, authenticity, emotions and analytical tones). Two independent assessors categorized the conclusiveness of the efficacy of interventions into nine categories.ResultsThe overall median SMOG index for 275 PLSs was 13.0 (95% confidence interval [CI] 12.8–13.3). Readability scores did not differ across Cochrane Review Groups. SAs had a higher readability index than the corresponding PLSs (median = 16.6, 95% CI = 16.4–16.8). Regarding linguistic characteristics, PLSs were shorter than SAs, with less use of analytical tone, but more use of a positive emotional tone and authenticity. Overall, the ‘Unclear’ category of conclusiveness was the most common among all PLSs. Also, PLSs with ‘No evidence’ conclusions were the shortest and had the lowest SMOG index.ConclusionPLSs of Cochrane systematic reviews of oncological interventions have low readability and most give unclear conclusions about the efficacy of interventions. PLSs should be simplified so that patients and their families can benefit from appropriate health information on evidence synthesis. Further research is needed into reasons for unclear language to describe evidence from oncology trials.
Clinicopathological features and prognosis of breast cancer combined with symptomatic bone marrow metastases: A 10‐year, single‐center, real‐world study of 67 cases
Authors: Niu Limin , Lv Huimin , Zhang Mengwei , Zeng Huiai , Fu Shuzhen , Cui Shude , Liu Zhenzhen , Yan Min 
Published: March 2023

AbstractPurposeBone marrow metastasis (BMM) is uncommon in breast cancer (BC), and early diagnosis is challenging. BMM lacks definitive treatment options and poses a great threat to the survival of patients. Herein, we investigated the clinical features, prognosis, and factors affecting the prognosis of BC patients with symptomatic BMM to help improve the understanding of this disease and provide effective diagnostic and treatment strategies.MethodsClinical data of 67 patients with BC and BMM were retrospectively analyzed for clinical characteristics, treatment, and prognosis of BMM. Univariate and multivariate analyses were performed to determine factors affecting overall survival following BMM (BMMOS).ResultsAmong patients with BMM, 86.6% were diagnosed after bone metastasis (BM), while 13.4% were diagnosed simultaneously with BM. A total of 73.1%, 13.4%, and 13.4% of the patients had hormone receptor‐positive/human epidermal growth factor 2‐negative (HR+/HER2−) tumors, HER2+ tumors, and triple‐negative tumors, respectively. The most common symptoms of BMM were the coexistence of anemia and thrombocytopenia (26.9%), anemia (19.4%), and pancytopenia (17.9%). The median BMMOS was 7.6 months (95% CI, 3.9–11.3). Univariate and multivariate analyses showed that BMMOS was associated with platelet count <75 × 109/L at the time of BMM diagnosis. The BMMOS of patients who underwent endocrine therapy, combined chemotherapy, and mono‐chemotherapy after BMM was 15.7, 9.7, and 8.6 months, respectively, whereas that of untreated patients was 2.9 months, and the difference among the results was statistically significant (χ2 = 20.102, p < 0.0001). Changes in patient hemogram and/or body temperature during treatment were consistent with the overall effect of the disease (p < 0.0001).ConclusionBMM should be considered in BC patients with BM, an unexplained reduction in hemogram parameters, especially anemia and thrombocytopenia, and/or fever without chills. Active, effective, individualized treatment strategies can prolong BMMOS.
New Arylazo‐Based (Chromene‐Thiazole) Hybrids as Potential MRSA Inhibitors
Authors: Abdallah Zeinab A. , Sanad Sherif M. H. , Mekky Ahmed E. M. , Ahmed Mohamed S. Mohamed 
Published: March 2023

AbstractA three‐component protocol was established to efficiently synthesize (chromene‐thiazole) and related arylazo analogs in good to excellent yields. The desired products were prepared by reacting the appropriate salicylaldehydes, 2‐cyanothioacetamide, and chloroacetone or hydrazonyl chlorides. Using piperidine as a mediator in ethanol at 80 °C for 4–6 h, the three‐component protocol produce the target hybrids in 87–96 % yields. The newly synthesized products showed a broad range of antibacterial activity. The addition of an arylazo unit at the chromene‐C6 position significantly improved the antibacterial activity, while the impact of adding an arylazo group at the thiazole‐C5 position varied based on the electronic characteristics of the para‐substituted arene unit. Generally, series that is linked to two arylazo units, one at chromene‐C6 and the other at thiazole‐C5, showed the best activity. Some new hybrids showed effective antibacterial activity than ciprofloxacin with MIC/MBC values up to 1.9/3.9 μM against S. aureus and E. coli. Additionally, they demonstrated better effectiveness against MRSA ATCC:33591 and ATCC:43300 compared to linezolid, with MIC/MBC values up to 4.0/16.1 and 3.9/15.6 μM, respectively. The data predicted for the physicochemical properties, lipophilicity, pharmacokinetics, and drug‐likeness of new arylazo‐based chromene‐thiazole hybrids evaluated by SwissADME. As a result of the above, products that are linked to two arylazo units can be considered drug‐like scaffolds.
Impact of microwave and germination on physicochemical properties, functional properties, and solubility of black rice powder
Authors: Zhang Yucui , Liu Tengnu , Zhang Xinxia , Li Ting , Wang Li 
Published: March 2023

AbstractBackground and ObjectivesBlack rice is limited due to factors such as low solubility, difficulty to disperse, and high viscosity. The aim of the study is to overcome these shortcomings and improve their practicability in various industrial applications. The effects of germination and microwave on the physicochemical properties, functional properties, and solubility of black rice powder were compared.FindingsThe effect of germination improved the GABA contents, increased the solubility and starch digestibility, which was consistent with the decrease in relative crystallinity and porous surface structure, and the increase in the gelatinization enthalpy. Microwave increased the solubility and starch digestibility of black rice powder. Total polyphenol content was increased by microwave compared to untreated and germinated black rice. The type of starch showed no significant effect in single and dual treatment. The combined treatment enhanced the GABA content, reduced the loss of polyphenols, anthocyanins and improved its solubility, physicochemical properties characteristics.ConclusionThe results might help understand the mechanism of germination and microwave treatments influencing the structural properties of starches and contribute to better‐developing products based on black rice flour.Significance and NoveltyThe association treatment increased GABA content, the solubility, and nutrition of black rice flour, but reduced the digestibility of black rice flour.
Efficient and Sustainable One‐pot Synthesis of α‐Carbonyl Homoallylic Alcohols from Benzaldehyde and Allylic Alcohols Using both NHC and Nickel Catalysts
Authors: Homrani Yasmina , Mouhsine Bouchaib , Béthegnies Aurélien , El Amrani Mohamed Amin , Karim Abdallah , Suisse Isabelle , Sauthier Mathieu 
Published: March 2023

Abstractα‐carbonyl homoallylic alcohols have been synthesized in a one‐pot reaction from benzaldehyde and allylic alcohols. The nickel‐catalyzed allylation of α‐hydroxyketones has first been studied and allowed the identification of Ni(cod)2/dppf as the most suitable catalytic system. The tandem reaction that combines the benzoin condensation of aldehydes (synthesis of α‐hydroxyketones) promoted by the 1,3‐dimethylimidazolium chloride/DBU system and the nickel‐catalyzed allylic alkylation with allylic alcohol has been realized in EtOH as green solvent. The reaction is 100 % atom‐economical and water is formed as sole by‐product. A broad scope of different benzaldehyde derivatives as well as various allylic alcohols is also described.
Atroposelective Nenitzescu Indole Synthesis
Authors: Thönnißen Vinzenz , Atodiresei Iuliana L. , Patureau Frederic W. 
Published: March 2023

AbstractInvited for the cover of this issue is the group of Frederic W. Patureau at the RWTH Aachen University. The image depicts atropoisomerism, in particular through the helix‐shaped vines in the forefront focus. This metaphorically illustrates the importance of atroposelectivity in biologically active molecules, such as in the 5‐hydroxyindoles that were accessed through the first enantioselective Nenitzescu indole synthesis. Read the full text of the article at 10.1002/chem.202300279.
Synthesis and stereodynamics of intramolecular hemiacetals in biaryl aldehyde‐alcohols
Authors: Heitsch Simone , Mayer Lena Carina , Pignot Yanis Luca , Trapp Oliver 
Published: March 2023

AbstractSoai's asymmetric autocatalysis represents a highly remarkable example for spontaneous symmetry breaking and enantioselective amplification in the enantioselective alkylation of pyrimidine‐5‐carbaldehydes to the corresponding chiral pyrimidine alcohols. Recently, zinc hemiacetalate complexes, formed from pyrimidine‐5‐carbaldehydes and the chiral product alcohol, were identified by in situ high‐resolution mass spectrometric measurements as highly active transient asymmetric catalysts in this autocatalytic transformation. To study the formation of such hemiacetals and their stereodynamic properties, we focused on the synthesis of coumarin homolog biaryl systems with carbaldehyde and alcohol substituents. Such systems are able to form hemiacetals by intramolecular cyclization. An interesting feature of the substituted biaryl backbone is that tropos and atropos systems can be obtained, enabling or disabling the intramolecular cyclization to hemiacetals. Biaryl structures with various functional groups were synthesized, and the equilibrium and stereodynamics between the closed and open structures were investigated by dynamic enantioselective HPLC (DHPLC). The enantiomerization barriers ΔGǂ and activation parameters ΔHǂ and ΔSǂ were determined from temperature dependent kinetic measurements.
Safety and effectiveness of dupilumab in the real‐world treatment of atopic dermatitis in Japan: 1‐year interim analysis from a post‐marketing surveillance
Authors: Saeki Hidehisa , Fujita Hiroyuki , Suzuki Katsuhisa , Arima Kazuhiko 
Published: March 2023

AbstractObjectivesAtopic dermatitis (AD) is a common chronic inflammatory skin disorder in Japan. Dupilumab, a fully human monoclonal antibody, targets a shared subunit of the interleukin (IL)‐4 and IL‐13 receptors. Post‐marketing surveillance of the safety and effectiveness of dupilumab in adult AD patients was conducted in Japan, where the drug is also allowed for use in older adolescents (i.e., ≥15 years), and interim results are reported here.MethodsThis observational, multicenter study enrolled Japanese patients with AD who initiated dupilumab between July 2018–June 2020 (UMIN‐CTR Trials Registry: UMIN000032807). Baseline demographics, clinical history, medication data and dupilumab safety and effectiveness data were collected.ResultsBy the data cut‐off date of March 26, 2021, information from 600 patients has been collected. All the available safety and 1‐year effectiveness data are presented. The mean (standard deviation) age was 42.0 (15.9) years, the majority (69.1%) were male, and asthma was present in 12.2%. Adverse drug reactions (ADRs) were observed in 98 patients (16.4%), including conjunctivitis (n = 40; 6.7%), conjunctivitis allergic (n = 30; 5.0%), blepharitis (n = 5; 0.8%), headache and eye pruritus (n = 4; 0.7% each) and eosinophilia (n = 3; 0.5%). Six patients experienced asthma, all of whom had a history of, or concurrent, asthma. Disease severity improved remarkably at 4 months in most patients, which was maintained up to 1 year.ConclusionDupilumab appears to be a safe and effective treatment for patients aged ≥15 years with moderate‐to‐severe AD in routine clinical practice in Japan. Dupilumab was well tolerated, with no new safety signals and no new‐onset asthma.