bluuebunny/crossref_metadata_2025_split huggingface dataset:
Egyptian recommendations for the management of systemic lupus erythematosus: a consensus, evidence-based, clinical practice guidelines for treat-to-target management
Authors: El Miedany Yasser , Elhadidi Khaled , Mahmoud Geilan Abdelmoneim , Abu-Zaid Mohammed Hassan , Mahmoud Atef Abdelazim , El Gaafary Maha , Kamel Nadia , Fathi Nihal Ahmed , Nasser Ahmed Abdel , Hassan Waleed , Eissa Mervat , Sarhan Eman , Aboalfadl Essam , Mansour Ahmed Ezzat , Mortada Mohamed , Fouad Nermeen Ahmed , Elaraby Ismail , Elnemr Rehab , Medhat Basma M. , Mohamed Sally S. , Ibrahim Rehab Ali , Tabra Samar abd Alhamed , Saber Sally , Franklin Genny , Mokbel Abir 
Published: April 2023

Abstract
Background
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by having varying clinical presentation, severity, unpredictable course as well as outcomes. Recent disease-modifying conventional and biologic agents have enhanced rates of attaining both short- and long-term management goals, including minimization of glucocorticoid dose and use. This study was carried out to develop an up-to-date evidence-based, consensus on clinical practice guidelines for treat-to-target management of systemic lupus erythematosus in adults.

Results
The response rate to the online questionnaires, sent to the expert panel who participated in the three rounds, was 95.5%. At the end of round 3, a total of 14 recommendation sections were proposed for the T2T management of patients with SLE. Agreement with the recommendations (rank 7–9) ranged from 90.9–100%. Consensus was reached (i.e., ≥ 80% of respondents strongly agreed or agreed) on the proposed statements.

Conclusion
These recommendations provide a consensus on the treat-to-target management of patients with SLE. They provide strategies to reach optimal outcomes in common clinical scenarios, based on a combination of evidence and expert opinion.
Visit to Visit Hemoglobin A1c Variation and Long-term Risk of Major Adverse Limb Events in Patients With Type 2 Diabetes
Authors: Hsiao Fu-Chih , Chan Yi-Hsin , Tung Ying-Chang , Lin Chia-Pin , Lee Ting-Hein , Wang Yu-Chiang , Chu Pao-Hsien 
Published: April 2023

Abstract

Context
Glycemic variation had been demonstrated to be associated with several complications of diabetes.

Objective
Investigation of the association between visit to visit hemoglobin A1c (HbA1c) variation and the long-term risk of major adverse limb events (MALEs).

Methods
Retrospective database study. Average real variability was used to represent glycemic variations with all the HbA1c measurements during the 4 following years after the initial diagnosis of type 2 diabetes. Participants were followed from the beginning of the fifth year until death or the end of the follow-up. The association between HbA1c variations and MALEs was evaluated after adjusting for mean HbA1c and baseline characteristics. Included were 56 872 patients at the referral center with a first diagnosis of type 2 diabetes, no lower extremity arterial disease, and at least 1 HbA1c measurement in each of the 4 following years were identified from a multicenter database. The main outcome measure was incidence of a MALE, which was defined as the composite of revascularization, foot ulcers, and lower limb amputations.

Results
The average number of HbA1c measurements was 12.6. The mean follow-up time was 6.1 years. The cumulative incidence of MALEs was 9.25 per 1000 person-years. Visit to visit HbA1c variations were significantly associated with MALEs and lower limb amputation after multivariate adjustment. People in the highest quartile of variations had increased risks for MALEs (HR 1.25, 95% CI 1.10-1.41) and lower limb amputation (HR 3.05, 95% CI 1.97-4.74).

Conclusion
HbA1c variation was independently associated with a long-term risk of MALEs and lower limb amputations in patients with type 2 diabetes.
Co-Harvest and Anaerobic Co-Storage of Corn Grain and Stover as Biomass Feedstocks
Authors: Pike Benjamin C. , Shinners Kevin J. , Timm Aaron J. , Friede Josh , Digman Matthew Francis 
Published: April 2023

Highlights

Cutting height and harvest date were used to alter stover moisture content, yield, and composition.

Anaerobic co-storage of grain and stover limited losses to less than 6% of dry matter.

Extent of fermentation was greater for higher moisture stover than grain, but total acids were less than 5 g kg-1.

Reducing the harvester cutter head rotational speed resulted in a greater fraction of whole corn kernels.

Abstract. This research investigated the utility of co-harvesting and anaerobic co-storage of corn grain and stover to positively influence their physical and chemical characteristics as a biomass feedstock. Corn grain and stover were harvested in 2019 and 2020 with a self-propelled forage harvester. Stover yield, moisture content, and composition were altered by the harvest date, stubble height, and header configuration. Harvest date had the utility of varying the stover moisture content (p &lt; 0.001) from 42.3% to 53.5% (w.b.) and 43.1% to 53.9% (w.b.) for the 2019 and 2020 harvest years, respectively. Stubble height was also utilized to vary stover moisture content. A negative linear relationship was established between stubble height and stover moisture content for the early (R2 = 0.76) and late harvest (R2 = 0.91) dates for both years. Stover yield also showed a negative linear relationship (R2 = 0.76) with stubble height over both years. Regardless of the stubble height, the row-crop header collected more stover (p &lt; 0.001) than the ear-snapper header. In 2020, harvested stover ranged from 5.0 to 10.5 Mg ha-1, with ha-1 representing 41% to 85% of the total available stover. In both years, stover ash content was less than 64 g kg-1. Material stored in pilot-scale silos (19 L) was well conserved during anaerobic storage, with average DM losses of 4.8% and 3.4% in 2019 and 2020, respectively. Grain moisture content averaged 23.6% (w.b.) at harvest, and 31.0% (w.b.) after storage as moisture migrated from the moist stover to the drier grain. Harvesting whole-plant corn with a forage harvester had the unwanted effect of reducing the particle size of the grain fraction, which would complicate downstream utilization. However, reducing the harvester cutterhead speed increased the fraction of intact kernels from 47% to 85% by mass. The studied system was a viable alternative to conventional corn grain and stover systems for producing feedstocks for biochemical conversion. Keywords: Ash, Ensiling, Ethanol, Maize.
An anesthesia-centered bundle to reduce postoperative pulmonary complications: The PRIME-AIR study protocol
Authors: Fernandez-Bustamante Ana , Parker Robert A. , Sprung Juraj , Eikermann Matthias , Gama de Abreu Marcelo , Ferrando Carlos , Thompson B. Taylor , Vidal Melo Marcos F. 
Published: April 2023

Background
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality after open abdominal surgery. Optimized perioperative lung expansion may minimize the synergistic factors responsible for the multiple-hit perioperative pulmonary dysfunction. This ongoing study will assess whether an anesthesia-centered bundle focused on perioperative lung expansion results in decreased incidence and severity of PPCs after open abdominal surgery.

Methods
Prospective multicenter randomized controlled pragmatic trial in 750 adult patients with at least moderate risk for PPCs undergoing prolonged (≥2 hour) open abdominal surgery. Participants are randomized to receive either a bundle intervention focused on perioperative lung expansion or usual care. The bundle intervention includes preoperative patient education, intraoperative protective ventilation with individualized positive end-expiratory pressure to maximize respiratory system compliance, optimized neuromuscular blockade and reversal management, and postoperative incentive spirometry and early mobilization. Primary outcome is the distribution of the highest PPC severity by postoperative day 7. Secondary outcomes include the proportion of participants with: PPC grades 1–2 through POD 7; PPC grades 3–4 through POD 7, 30 and 90; intraoperative hypoxemia, rescue recruitment maneuvers, or cardiovascular events; and any major extrapulmonary postoperative complications. Additional secondary and exploratory outcomes include individual PPCs by POD 7, length of postoperative oxygen therapy or other respiratory support, hospital resource use parameters, Patient-Reported Outcomes Measurements (PROMIS®) questionnaires for dyspnea and fatigue collected before and at days 7, 30 and 90 after surgery, and plasma concentrations of lung injury biomarkers (IL6, IL-8, RAGE, CC16, Ang-2) analyzed from samples obtained before, end of, and 24 hours after surgery.

Discussion
Participant recruitment for this study started January 2020; results are expected in 2024. At the conclusion of this trial, we will determine if this anesthesia-centered strategy focused on perioperative lung expansion reduces lung morbidity and healthcare utilization after open abdominal surgery.

Trial registration
ClinicalTrial.gov NCT04108130.
Ensuring that a school-based smoking cessation program for adolescents is successful: A realist evaluation of the TABADO program and the program theory
Authors: Vallata Amandine , Alla François 
Published: April 2023

Background
A smoking cessation program for adolescents, TABADO, demonstrated its effectiveness following a controlled trial conducted in 2007/2009. The program is now being scaled up nationally. In order to retain its efficacy across the diversity of contexts in the generalization process, we needed to assess the processes and mechanisms that inform its effects. Theory-driven evaluation is one approach used to address these issues. The aim of the present research is to develop the TABADO program theory. More specifically, we attempt to identify the factors and mechanisms that promote or hinder the enrollment and retention of student smokers in the program.

Methods
We conducted a realist evaluation of the TABADO program through 1) a documentary analysis to construct the initial program theory, and 2) a multiple case study (n = 10) conducted in three regions in France to test and enrich the initial theory with contextual, organizational and mechanistic components. We used the Intervention-Context-Actors-Mechanisms-Outcomes configurations to guide our analysis and to present our results.

Results
Our analysis highlighted 13 mechanisms that foster the enrollment and retention of student smokers in the TABADO program (e.g., being prepared to quit smoking, feeling encouraged in the attempt to quit smoking). To activate these mechanisms, the involvement of various actors is required (e.g., the school nurse, teachers), together with a combination of interventional and contextual factors (e.g., confidentiality, informal speaking time).

Conclusions
These findings allowed us to transform the TABADO program into a new optimized strategy, TABADO2, which is theory-based. Our research helps to explain why adolescent smokers enroll and stay in a school-based smoking cessation program. TABADO2 needs to be considered in a more comprehensive way than the original research-based TABADO, and should be tailored to its implementation context.
Deep learning for detection of age-related macular degeneration: A systematic review and meta-analysis of diagnostic test accuracy studies
Authors: Leng Xiangjie , Shi Ruijie , Wu Yanxia , Zhu Shiyin , Cai Xingcan , Lu Xuejing , Liu Ruobing 
Published: April 2023

Objective
To evaluate the diagnostic accuracy of deep learning algorithms to identify age-related macular degeneration and to explore factors impacting the results for future model training.

Methods
Diagnostic accuracy studies published in PubMed, EMBASE, the Cochrane Library, and ClinicalTrails.gov before 11 August 2022 which employed deep learning for age-related macular degeneration detection were identified and extracted by two independent researchers. Sensitivity analysis, subgroup, and meta-regression were performed by Review Manager 5.4.1, Meta-disc 1.4, and Stata 16.0. The risk of bias was assessed using QUADAS-2. The review was registered (PROSPERO CRD42022352753).

Results
The pooled sensitivity and specificity in this meta-analysis were 94% (P = 0, 95% CI 0.94–0.94, I2 = 99.7%) and 97% (P = 0, 95% CI 0.97–0.97, I2 = 99.6%), respectively. The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under the curve value were 21.77(95% CI 15.49–30.59), 0.06 (95% CI 0.04–0.09), 342.41 (95% CI 210.31–557.49), and 0.9925, respectively. Meta-regression indicated that types of AMD (P = 0.1882, RDOR = 36.03) and layers of the network (P = 0.4878, RDOR = 0.74) contributed to the heterogeneity.

Conclusions
Convolutional neural networks are mostly adopted deep learning algorithms in age-related macular degeneration detection. Convolutional neural networks, especially ResNets, are effective in detecting age-related macular degeneration with high diagnostic accuracy. Types of age-related macular degeneration and layers of the network are the two essential factors that impact the model training process. Proper layers of the network will make the model more reliable. More datasets established by new diagnostic methods will be used to train deep learning models in the future, which will benefit for fundus application screening, long-range medical treatment, and reducing the workload of physicians.
Comparison of the efficacy and invasiveness of manual and automated gonioscopy
Authors: Takagi Yuki , Watanabe Mitsunori , Kojima Takashi , Sakai Yukihiro , Asano Ryo , Ichikawa Kazuo 
Published: April 2023

Purpose
To compare the efficacy and invasiveness of manual gonioscopy and automated 360-degree gonioscopy.

Method
Manual and automated gonioscopy were performed on 70 patients with glaucoma. Manual gonioscopy was performed by a glaucoma specialist and an ophthalmology resident, and automated gonioscopy (GS-1) was performed by orthoptists. We compared the examination time for acquiring gonioscopic images (GS-1: 16 directions; manual gonioscopy: 8 directions). Furthermore, we compared the pain and discomfort scores during the examination using the Individualized Numeric Rating Scale. Among the images acquired by automated gonioscopy, we also evaluated the percentages of acquired images that could be used to determine the angle opening condition.

Results
The examination time was not significantly different between manual (80.2±28.7) and automated gonioscopy (94.7±82.8) (p = 0.105). The pain score of automated gonioscopy (0.22±0.59) was significantly lower than that of manual gonioscopy (0.55±1.11) (p = 0.025). The discomfort score was not significantly different between manual (1.34±1.90) and automated gonioscopy (1.06±1.50) (p = 0.165). Automated gonioscopy successfully acquired clear gonioscopic images in 93.4% of the total images.

Conclusion
Automated gonioscopy is comparable in examination time and invasiveness to manual gonioscopy and may be useful for 360-degree iridocorneal angle evaluation.
Drag in a Changing Scene, Volumes 1 & 2
Volume 1: Contemporary Drag Practices and Performers, Mark Edward and Stephen Farrier (Eds) (2020)
Volume 2: Drag Histories, Herstories and Hairstories, Mark Edward and Stephen Farrier (Eds) (2022)
Authors: Whitworth Colin 
Published: April 2023

Review of: Drag in a Changing Scene, Volumes 1 & 2
Volume 1: Contemporary Drag Practices and Performers, Mark Edward and Stephen Farrier (Eds) (2020)
London: Methuen Drama, 248 pp.,
ISBN 978-1-35008-294-6, h/bk, $110.00
ISBN 978-1-35031-919-6, p/bk, $39.95
ISBN 978-1-35008-295-3, e-book, $35.95
Volume 2: Drag Histories, Herstories and Hairstories, Mark Edward and Stephen Farrier (Eds) (2022)
London: Methuen Drama, 256 pp.,
ISBN 978-1-35010-436-5, h/bk, $115.00
ISBN 978-1-35019-851-7, p/bk, $39.95
ISBN 978-1-35010-437-2, e-book, $35.95
Reconstructing axons from sectioned brains through alignment and stitching
Authors: Bakker Rembrandt , Rubio-Teves Mario , Timonidis Nestor , García-Amado María , Clascá Francisco , Tiesinga Paul 
Published: April 2023

Since the turn of this century, new and powerful cell labeling techniques have allowed the consistent and complete labeling of axonal arborizations of individual long range projection neurons (LRPNs) in mouse (Furuta et al, 2001). The prospect of creating a connectome at the cellular level, together with new developments in the automated scanning of whole (rodent) brain volumes, has resulted in a the release of thousands of fully reconstructed LRPNs (Peng et al. 2021, Winnubst et al. 2019).
In parallel with this number-driven ‘industrial’ approach, there are smaller scale, hypothesis-driven projects that focus on particular populations of neurons, perform targeted single-cell labeling experiments and explore the resulting data to the maximum possible extent. In this setting, axons are traced from a stack of brain slices, stained to highlight particular features and mounted on a glass slide. Tracing axons from this data is a two step process:
1. Find all pieces of axon in each individual section, carried out with microscope-attached software NeuroLucida (MBF Bioscience)
2. Connect pieces of axon across adjacent sections to create a full axonal reconstruction, a process that we refer to as alignment and stitching.
This work takes care of the second step, having sections with traced axonal fragments as input, and complete axons as output. Our approach consists of:

Preparation of a structured dataset that contains for each section all pieces of axon and a section image in a shared coordinate system. Implemented in Python.

Alignment of sections using two complementary methods:

For sections that contain only a few pieces of axon: use a tissue-based alignment tool that presents the user with the overlay of (a) a tissue section, (b) the contours of the adjacent section, and (c) all pieces of axon that are traced in the two sections. The user manually rotates and shifts the overlay to obtain the best possible match. Implemented as a web-based tool.

For sections with many pieces of axon: align sections to create a maximum number of matching pieces, using a modified version of the Dercksen et al. (2005) algorithm. Implemented in Python.

Stitching pieces of neuron using a greedy approach that starts with an initial segment (the soma), and at each iteration connects a piece from the set of unconnected pieces to one of the endings of the growing neuron, in such a way that the added axonal length is minimal, and permitting only stitches between adjacent sections. Implemented in Python.

Registration: combine slices into a volume by using the POSSUM pipeline of Majka et al. (2016) and use 3d warping to register to a reference space.
Depathologization as Healing Justice
Authors: Rodriguez S. M. , Rakes H , Healy Kennedy , Ben-Moshe Liat 
Published: April 2023

Abstract
Healing justice, as with disability justice, and transformative justice/abolition, has largely been a queer-, trans-, woman of color-led intervention into the rights-based, reform-based, and neo/liberal agendas of whitestream movements. We see each of these movements for justice as deeply intertwined with the others, where interdependence and leaving no one behind are key commitments that are not compatible with the individualism of rights and reforms. In this roundtable conversation, we define depathologization and its relation to (queering) anti-normativity; discuss it as an important coalitional site of liberation; an intervention of abolitionist worldmaking. We argue that healing need not be understood in a corrective, carceral (medical) or ableist lens. Rather, healing justice models a philosophy and praxis of anticolonial resistance, communal interdependence, and abolitionist care. We offer the conversation as praxis and a way of learning and unlearning from each other.
Color Blind: Political Realism, Epistemic Racism, And Rhetorical Salience
Authors: Hariman Robert , Beer Francis A. 
Published: April 2023

Abstract
The rhetoric of any academic discipline can involve epistemic distortions and blind spots, including a tendency to obscure systemic racism. The doctrine of political realism from the discipline of International Relations is an influential example. Realism relies on several rhetorical devices, including a structural distinction between rhetoric and reality, a modality of abstraction, and the trope of anarchy/hierarchy. These provide both a compelling theoretical framework and a discursive program that obscures race and racism. Realist discourse operates further through several dimensions of rhetorical salience that are modulated by changes in context. Foreground, background, ambient, and ontic salience provide multiple registers for inscribing realism. Realism's lack of reflexivity in disciplinary, governmental, and public arenas adds to its power and its defects. Exposing the rhetorical constitution of realism and its architecture of non-knowing raises challenges not only for realism but also for rhetoric. These include avoiding the inscription of realism and racism within rhetorical inquiry and avoiding epistemic hubris in the self-definition of rhetoric as a discipline.
Validity and reproducibility of a whole‐room indirect calorimeter for the estimation of VO2, VCO2, and resting metabolic rate
Authors: Henriksen Hege Berg , Henriksen Christine , de Sousa Ana Rita Sequeira , Alavi Dena Treider , Augestad Elin Maria Sandstad , Rising Russell , Dörner Rebecca , Hägele Franziska Anna , Bosy‐Westphal Anja , Blomhoff Rune , Ulven Stine Marie , Olsen Thomas 
Published: April 2023

AbstractWhole‐room indirect calorimeters (WRICs) provide accurate instruments for the measurement of respiratory exchange, energy expenditure, and macronutrient oxidation. Here, we aimed to determine the validity and reproducibility of a 7500 L WRIC for the measurement of ventilation rates and resting metabolic rate (RMR). Technical validation was performed with propane combustion tests (n = 10) whereas biological reproducibility was tested in healthy subjects (13 women, 6 men, mean ± SD age 39.6 ± 15.3) in two 60 min measurements separated by 24 h. Subjects followed a run‐in protocol prior to measurements. The coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for ventilation rates of O2 (VO2), CO2 (VCO2), the respiratory quotient (RQ; VCO2/VO2), and RMR. Technical validation showed good validity with CVs ranging from 0.67% for VO2 to 1.00% for energy expenditure. For biological reproducibility, CVs were 2.89% for VO2; 2.67% for VCO2; 1.95% for RQ; and 2.68% for RMR. With the exception of RQ (74%), ICCs were excellent for VO2 (94%), VCO2 (96%) and RMR (95%). Excluding participants that deviated from the run‐in protocol did not alter results. In conclusion, the 7500 L WRIC is technically valid and reproducible for ventilation rates and RMR.