bluuebunny/crossref_metadata_2025_split huggingface dataset:
The usefulness of addition of breast-specific gamma imaging to mammography in women with dense breast
Authors: Kim Young Joong , Seo Jae Young , Kim Keum Won , Hwang Cheol Mog , Oh Dong Hyun 
Published: May 2023

Abstract
Background
Mammography (MG) has been adopted as a screening modality for breast cancer. However, the diagnostic yield was reported to decrease in women with dense breasts in MG. Several modalities have been introduced to improve the drawbacks. Breast-specific gamma imaging (BSGI) is a new technique in nuclear medicine imaging that could support breast cancer diagnosis. The aim of this study was to evaluate whether the addition of BSGI according to MG category could improve the accuracy of diagnosis and reduce unnecessary studies or biopsies.

Results
From February 2013 to December 2018, 548 patients with 628 breast lesions were enrolled in this retrospective study. The performances of BSGI and MG were evaluated for detecting breast cancer. We classified subgroups by adding the results of BSGI for BI-RADS category 0 and 4a lesions on MG. For each subgroup, diagnostic performance was calculated in overall and dense/non-dense. Factors associated with false-negative BSGI were evaluated. The sensitivity of BSGI (88.26%) was comparable to that of MG (87.95%) (P > 0.05). Specificity (81.44%) and AUC (0.85) of BSGI were significantly superior to those of MG (66.83% and 0.77, respectively). In the subgroup analysis of BSGI plus MG, the sensitivity of BSGI + MG0 and BSGI + MG4a were 95.98% and 94.64%, respectively. And specificities were 69.80% and 77.23%, respectively. Sensitivity and AUC of subgroups increased significantly compared to those of MG alone in overall and dense breasts. A nodule ≤ 10 mm and a low Ki-67 showed significant association with the false negativity of BSGI.

Conclusions
Applying BSGI to MG, notably for breast lesions with BI-RADS category 0 or 4a, could improve the diagnostic performance, even in dense breasts.
Investigating the feasibility of developing a collective action for biological control of fall armyworm among smallholder farmers in rural communities of Zambia
Authors: Durocher-Granger Léna , Fiorito Sara , Mudenda Sibajene Kambanja , Chiboola Milimo Mildred , Kansiime Monica K. , Ludwig David , Leeuwis Cees 
Published: May 2023

Abstract
Background
Fall armyworm, Spodoptera frugiperda, an alien invasive pest from the Americas, was detected in Zambia late 2016 and since has caused significant losses on maize threatening livelihood and food security. Individually, farmers continue to rely on synthetic pesticides, a reactive measure to manage new invasive insect pests, posing risks to human health, the environment and biodiversity. Biological control has been proven to be an efficient, cost effective and safe method for pest and disease management, and when adopted collectively, its effectiveness can increase. In addition, collective action has been acknowledged to be a critical component for invasive species management, but is still poorly studied in low- and middle-income countries (LMIC) where the national plant health system, in-place to prevent and manage biological invasions, is limited.

Methods
To study the feasibility of creating a collective action to promote biological control for fall armyworm among smallholder farmers in rural Zambia and the social and institutional conditions needed for it to be successful and sustainable, we conducted focus group discussions and in-depth interviews in two districts with maize smallholder farmers. Our model to assess the results applies both Ostrom’s 8 Design Principles for a community-based management of common-pool resources and criteria of an agricultural innovation that meet the community’s requirements, and also pays attention to the exchange and brokering processes needed to match the two.

Results
Our results showed that some conditions are already in place to support a collective action to manage fall armyworm such as matching rules to local conditions, collective-choice arrangement, conflict-resolution mechanism and minimal recognition of rights to organize which are supported by traditional leadership of the communities. However other conditions would need to be strengthened for the collective pest management to be sustainable. The most important criteria for a pest management innovation selected by participants from both districts, in no specific order, were price, efficacy, recommended by agrodealer/extension officer and immediate action.

Conclusions
This study fills a gap in understanding social and institutional conditions in LMIC needed to sustain a collective action that aim at controlling a highly mobile and invasive pest. Our study emphasizes the need to redefine technologies and dissemination in terms of supporting the processes of co-designing innovation based on social and ecological conditions.
In Vitro Prototyping of a Nano-Organogel for Thermo-Sonic Intra-Cervical Delivery of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles for Cervical Cancer
Authors: Adeyemi Samson A. , Az-Zamakhshariy Zardad , Choonara Yahya E. 
Published: May 2023

AbstractSolid lipid nanoparticles (SLNs) are used extensively to achieve site-specific drug delivery with improved bioavailability and reduced toxicity. This work focused on a new approach to provide site-specific stimuli-responsive delivery of SLNs loaded within thermo-sonic nano-organogel (TNO) variants to deliver the model chemotherapeutic agent 5-FU in treating cervical cancer. Pharmaceutically stable nanospherical SLNs comprising poly-L-lactic acid (PLA), palmitic acid (PA), and polyvinyl alcohol (PVA) were prepared and incorporated into TNO variants augmented by external thermal and ultrasound stimuli for release of 5-FU in the cervix. Results revealed that rate-modulated 5-FU release was achieved from SLNs (particle size =450.9 nm; PDI =0.541; zeta potential =−23.2 mV; %DL =33%) within an organogel upon exposure to either a single (thermo-) and/or both (thermo-sonic) stimuli. 5FU was released from all TNO variants with an initial burst on day 1 followed by sustained release over 14 days. TNO 1 provided desirable release over 15 days (44.29% vs. 67.13% under single (T) or combined (TU) stimuli, respectively). Release rates were primarily influenced by the SLN:TO ratio in tandem with biodegradation and hydrodynamic influx. Biodegradation by day 7 revealed that variant TNO 1 (1:5) released 5FU (46.8%) analogous to its initial mass than the other TNO variants (i.e., ratios of 2:5 and 3:5). FT-IR spectra revealed assimilation of the system components and corroborative with the DSC and XRD analysis (i.e., in ratios of PA:PLA 1:1 and 2:1). In conclusion, the TNO variants produced may be used as a potential stimuli-responsive platform for the site-specific delivery of chemotherapeutic agents such as 5-FU to treat cervical cancer.
Trotsky and the Wild Orchids
Authors: Rorty Richard 
Published: May 2023

Abstract
Among Rorty's most admired essays, and probably his most autobiographical, “Trotsky and the Wild Orchids” made its first appearance as a column in Common Knowledge during the journal's inaugural year. Here it is reprinted, thirty years later, in a symposium called “Whatever Happened to Richard Rorty?” He explains in this essay that, as a child, he loved things that would seem to others contradictory, for example the Trotskian socialism to which his family was committed and the wild orchids that he would search for in the local mountains. Finding his own way between what appeared to others contrary kinds of demand or appeal, he never settled, as a philosopher and public intellectual, on syntheses that made good sense to his contemporaries. They were unable to locate him on their intellectual and political maps. As he writes, “If there is anything to the idea that the best intellectual position is one which is attacked with equal vigor from the political right and the political left, then I am in good shape. . . . The left's favorite word for me is ‘complacent,’ just as the right's is ‘irresponsible.’ ” The editors of Common Knowledge, a venue that Rorty helped to found, have reprinted this essay as a way of stating their view that nothing has “happened to Richard Rorty” in the past three decades that did not happen as well when he was active in his own self-defense. He was misconstrued but indispensable when alive, and has remained so in the decades since.
Rorty Against Rorty
Authors: Gaskill Nicholas 
Published: May 2023

AbstractAs the leading contribution to the Common Knowledge symposium “Whatever Happened to Richard Rorty?,” this essay asks why Rorty was so often taken to be saying things that he claimed he was not. The argument is that Rorty's rhetorical approach and jargon engendered this confusion and undermined his effectiveness as a philosopher and public intellectual. The focus here is on two points: first, on how, in his eagerness to shut down attempts to claim a privileged path to Reality, he gave the impression of dismissing not only hierarchies but also distinctions; and second, on how his separation of causes and reasons retained a dualism of the “one world, many perspectives” model that elsewhere he rejected. This essay concludes that leading figures of science studies at the present time, notably Bruno Latour, Isabelle Stengers, and Donna Haraway, better equip readers to move past the feeling of deprivation that comes from shedding centuries-old philosophical assumptions and that their explicit rejection of the nature/culture binary makes their work better suited to addressing the great problem of our time — climate change.
RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells
Authors: Liu Shuyu , Sun Dawei , Butler Richard , Rawlins Emma L. 
Published: May 2023

ABSTRACT
Multipotent epithelial progenitor cells can be expanded from human embryonic lungs as organoids and maintained in a self-renewing state using a defined medium. The organoid cells are columnar, resembling the cell morphology of the developing lung tip epithelium in vivo. Cell shape dynamics and fate are tightly coordinated during development. We therefore used the organoid system to identify signalling pathways that maintain the columnar shape of human lung tip progenitors. We found that EGF, FGF7 and FGF10 have distinct functions in lung tip progenitors. FGF7 activates MAPK/ERK and PI3K/AKT signalling, and is sufficient to promote columnar cell shape in primary tip progenitors. Inhibitor experiments show that MAPK/ERK and PI3K/AKT signalling are key downstream pathways, regulating cell proliferation, columnar cell shape and cell junctions. We identified integrin signalling as a key pathway downstream of MAPK/ERK in the tip progenitors; disrupting integrin alters polarity, cell adhesion and tight junction assembly. By contrast, stimulation with FGF10 or EGF alone is not sufficient to maintain organoid columnar cell shape. This study employs organoids to provide insight into the cellular mechanisms regulating human lung development.
The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration
Authors: Rao Anupama , Lyu Baken , Jahan Ishrat , Lubertozzi Anna , Zhou Gao , Tedeschi Frank , Jankowsky Eckhard , Kang Junsu , Carstens Bryan , Poss Kenneth D. , Baskin Kedryn , Goldman Joseph Aaron 
Published: May 2023

ABSTRACT
The eIF4E family of translation initiation factors bind 5′ methylated caps and act as the limiting step for mRNA translation. The canonical eIF4E1A is required for cell viability, yet other related eIF4E families exist and are utilized in specific contexts or tissues. Here, we describe a family called Eif4e1c, for which we find roles during heart development and regeneration in zebrafish. The Eif4e1c family is present in all aquatic vertebrates but is lost in all terrestrial species. A core group of amino acids shared over 500 million years of evolution forms an interface along the protein surface, suggesting that Eif4e1c functions in a novel pathway. Deletion of eif4e1c in zebrafish caused growth deficits and impaired survival in juveniles. Mutants surviving to adulthood had fewer cardiomyocytes and reduced proliferative responses to cardiac injury. Ribosome profiling of mutant hearts demonstrated changes in translation efficiency of mRNA for genes known to regulate cardiomyocyte proliferation. Although eif4e1c is broadly expressed, its disruption had most notable impact on the heart and at juvenile stages. Our findings reveal context-dependent requirements for translation initiation regulators during heart regeneration.
Παρέμβαση στις σχολικές πρακτικές παραγωγής γραπτών μαθητικών κειμένων
Authors: Κέκια Μέλλω Αιμιλία 
Published: May 2023

Η παρούσα έρευνα έχει ως αντικείμενο τη διερεύνηση της εισαγωγής, ανάπτυξης και αξιολόγησης διεπιδραστικών και κοινωνιοκριτικών πρακτικών μάθησης και διδασκαλίας της παραγωγής και, ιδιαιτέρως, της αναθεώρησης του γραπτού μαθητικού λόγου σε μία σχολική τάξη ελληνικού δημόσιου αστικού δημοτικού σχολείου στο πλαίσιο μίας ετήσιας εθνογραφικής συμμετοχικής έρευνας δράσης, η οποία αποσκοπεί στην προαγωγή του κριτικού γραμματισμού των μαθητών. Η έρευνα αντλεί τη θεωρητική της θεμελίωση από τις κοινωνικοπολιτισμικές θεωρίες του γραπτού λόγου και του γραμματισμού, τις οποίες συνδυάζει με την κριτική γλωσσοπαιδαγωγική προσέγγιση του εργαστηρίου συγγραφέων και την ειδικότερη πρόταση της συλλογικής επαναδιατύπωσης γραπτών μαθητικών κειμένων. Για τη συλλογή και ανάλυση των δεδομένων της, ακολουθεί την εθνογραφική και κοινωνιογλωσσολογική παράδοση, και αξιοποιεί ποικιλία τεχνικών και μεθόδων για την ενδελεχή μελέτη του γραμματισμού της σχολικής τάξης ως κοινωνικής και πολιτισμικής διεργασίας. Τα ευρήματα από την εθνογραφική χαρτογράφηση των γεγονότων γραμματισμού της σχολικής τάξης, από τη διεπιδραστική μικροανάλυση του λόγου και των πρακτικών γραπτού λόγου, και από τη θεματική ανάλυση των γραπτών αναστοχασμών και των συνεντεύξεων της δασκάλας και των παιδιών, αναδεικνύουν μία δυναμική και πολυσύνθετη πορεία της αναδυόμενης κειμενικής κοινότητας της τάξης από αποπλαισιωμένες συγγραφικές και αναθεωρητικές πρακτικές προς κοινωνικές, διαδραστικές και αναστοχαστικές. Στο άρθρο προσδιορίζονται οι παράγοντες που ερμηνεύουν και εξηγούν την πορεία της μετατόπισης αυτής με βάση το θεωρητικό πλαίσιο της έρευνας και συζητούνται οι συνέπειες των πορισμάτων αυτών (α) για την έρευνα και (β) για τη διδασκαλία του γραπτού λόγου ως διεπιδραστικής και κοινωνικής πρακτικής με συγκεκριμένες συνεπαγωγές στην ανάπτυξη των εγγράμματων μαθητικών ταυτοτήτων στο σύγχρονο σχολείο.
Optimal Leveraged Portfolio Selection Under Quasi-Elastic Market Impact
Authors: Edirisinghe Chanaka , Chen Jingnan , Jeong Jaehwan 
Published: May 2023

Dangers of Ignoring Market Friction When Leveraging Financial PortfoliosPortfolio leveraging is a standard industry practice to target higher fund returns, for example, in risk parity asset allocation. However, the existing models of optimal bet sizing fail to integrate analytically the impact on leveraged portfolio selection resulting from market liquidity issues. The paper “Optimal Leveraged Portfolio Selection Under Quasi-Elastic Market Impact” considers a market in which both temporary and permanent impact on trading prices are present with the former impact being sufficiently large relative to the latter. Our analytical conclusions, supported by a case study that uses even relatively more liquid U.S. exchange-traded fund assets, demonstrate that fund managers are ill advised to ignore market friction when leveraging to achieve target higher returns. Not only risk-adjusted returns significantly deteriorate, but also those losses become steeper when setting higher targets requiring increased levels of leverage. Moreover, leverage-constrained and less risk-averse investors ignoring liquidity costs ex ante face the most losses in expected utility ex post.
The buffering role of social support on the severity of physical symptoms among patients living with cancer
Authors: Zeilani Ruqayya S , Younis Wejdan Y , Albusoul Randa , Hasanien Amer , Mansour Ayman Hamdan 
Published: May 2023

Background: The role of perceived social support (the individual's perception that family, friends and others are available as psychological, social and material support) and its moderating effect on the psychological and physical factors among patients suffering medical problems is still debated. Aim: To explore the effect of perceived social support on the relationship between psychological and health-related factors on the severity of physical symptoms among patients with cancer. Methods: A descriptive-correlational, cross-sectional design was used to recruit 459 patients with cancer from three major hospitals in Jordan. Data were collected using a self-administered questionnaire. Results: Social support was significantly correlated to the severity of physical symptoms (p>.05) among patients with cancer, while psychological distress, sadness, disturbed body image and anxiety were not (p<.05). The multiple hierarchal regression model showed that social support has no significant moderation effect on the relationship between psychological and health-related factors and the severity of physical symptoms controlling for sociodemographic factors among patients with cancer. Conclusion: Patients with cancer suffering physical and psychological disturbances do not benefit from social support as a way of controlling the severity of their symptoms. Palliative nurses need to tailor a social support intervention to their patients with cancer, in order to use both professional and family resources.
Radiostereometric analysis and clinical outcomes of a novel reverse total hip system at two years
Authors: Turgeon Thomas R. , Hedden David R. , Bohm Eric R. , Burnell Colin D. 
Published: May 2023

AimsInstability is a common cause of failure after total hip arthroplasty. A novel reverse total hip has been developed, with a femoral cup and acetabular ball, creating enhanced mechanical stability. The purpose of this study was to assess the implant fixation using radiostereometric analysis (RSA), and the clinical safety and efficacy of this novel design.MethodsPatients with end-stage osteoarthritis were enrolled in a prospective cohort at a single centre. The cohort consisted of 11 females and 11 males with mean age of 70.6 years (SD 3.5) and BMI of 31.0 kg/m2 (SD 5.7). Implant fixation was evaluated using RSA as well as Western Ontario and McMaster Universities Osteoarthritis Index, Harris Hip Score, Oxford Hip Score, Hip disability and Osteoarthritis Outcome Score, 38-item Short Form survey, and EuroQol five-dimension health questionnaire scores at two-year follow-up. At least one acetabular screw was used in all cases. RSA markers were inserted into the innominate bone and proximal femur with imaging at six weeks (baseline) and six, 12, and 24 months. Independent-samples t-tests were used to compare to published thresholds.ResultsMean acetabular subsidence from baseline to 24 months was 0.087 mm (SD 0.152), below the critical threshold of 0.2 mm (p = 0.005). Mean femoral subsidence from baseline to 24 months was -0.002 mm (SD 0.194), below the published reference of 0.5 mm (p < 0.001). There was significant improvement in patient-reported outcome measures at 24 months with good to excellent results.ConclusionRSA analysis demonstrates excellent fixation with a predicted low risk of revision at ten years of this novel reverse total hip system. Clinical outcomes were consistent with safe and effective hip replacement prostheses.Cite this article: Bone Jt Open 2023;4(5):385–392.
Non-pharmacological interventions for the prevention of sexually transmitted infections (STIs) in older adults: A systematic review
Authors: Co Melissa , Moreno-Agostino Darío , Wu Yu-Tzu , Couch Elyse , Posarac Ana , Wi Teodora , Sadana Ritu , Carlisle Sophie , Prina Matthew 
Published: May 2023

Background
STIs in older adults (adults aged 50 years and older) are on the rise due to variable levels of sex literacy and misperceived susceptibility to infections, among other factors. We systematically reviewed evidence on the effect of non-pharmacological interventions for the primary prevention of sexually transmitted infections (STIs) and high-risk sexual behaviour in older adults.

Methods
We searched EMBASE, MEDLINE, PSYCINFO, Global Health and the Cochrane Library from inception until March 9th, 2022. We included RCTs, cluster-randomised trials, quasi-RCTs, interrupted time series (ITS) and controlled and uncontrolled before-and-after studies of non-pharmacological primary prevention interventions (e.g. educational and behaviour change interventions) in older adults, reporting either qualitative or quantitative findings. At least two review authors independently assessed the eligibility of articles and extracted data on main characteristics, risk of bias and study findings. Narrative synthesis was performed.

Results
Ten studies (two RCTs, seven quasi-experiment studies and one qualitative study) were found to be eligible for this review. These interventions were mainly information, education and communication activities (IECs) aimed at fostering participants’ knowledge on STIs and safer sex, mostly focused on HIV. Most studies used self-reported outcomes measuring knowledge and behaviour change related to HIV, STIs and safer sex. Studies generally reported an increase in STI/HIV knowledge. However, risk of bias was high or critical across all studies.

Conclusions
Literature on non-pharmacological interventions for older adults is sparse, particularly outside the US and for STIs other than HIV. There is evidence that IECs may improve short-term knowledge about STIs however, it is not clear this translates into long-term improvement or behaviour change as all studies included in this review had follow-up times of 3 months or less. More robust and higher-quality studies are needed in order to confirm the effectiveness of non-pharmacological primary prevention interventions for reducing STIs in the older adult population.
To troll or not to troll: Young adults’ anti-social behaviour on social media
Authors: Soares Felipe Bonow , Gruzd Anatoliy , Jacobson Jenna , Hodson Jaigris 
Published: May 2023

Background
Online anti-social behaviour is on the rise, reducing the perceived benefits of social media in society and causing a number of negative outcomes. This research focuses on the factors associated with young adults being perpetrators of anti-social behaviour when using social media.

Method
Based on an online survey of university students in Canada (n = 359), we used PLS-SEM to create a model and test the associations between four factors (online disinhibition, motivations for cyber-aggression, self-esteem, and empathy) and the likelihood of being a perpetrator of online anti-social behaviour.

Results
The model shows positive associations between two appetitive motives for cyber-aggression (namely recreation and reward) and being a perpetrator. This finding indicates that young adults engage in online anti-social behaviour for fun and social approval. The model also shows a negative association between cognitive empathy and being a perpetrator, which indicates that perpetrators may be engaging in online anti-social behaviour because they do not understand how their targets feel.