bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ropinirole has similar efficacy to apomorphine for induction of emesis and removal of foreign and toxic gastric material in dogs
Authors: Rosenstein Natalie A. , Johnson Justine A. , Kirchofer Kevin S. 
Published: April 2023

Abstract

OBJECTIVE
Assess efficacy of ropinirole versus apomorphine in inducing vomiting in dogs.

ANIMALS
279 client-owned dogs with known or suspected ingestion of a foreign material (n = 129) or toxin (150) between August 2021 and February 2022.

PROCEDURES
In this non-randomized non-controlled clinical trial, ropinirole topical ophthalmic solution was applied to dogs’ eyes, with a target dose of 3.75 mg/m2. A second dose was administered after 15 minutes based on clinician discretion. Reversal with metoclopramide was provided based on clinician discretion. Results of ropinirole’s efficacy were compared to previous literature assessing the efficacy of apomorphine.

RESULTS
Of 279 dogs, 255 (91.4%) vomited after ropinirole administration, including 116 of the 129 dogs (89.9%) dogs that ingested foreign material and 139 of the 150 dogs (92.7%) that ingested toxins. Success of emesis did not differ between groups. With a single dose of ropinirole, 78.9% produced vomit. Fifty-nine dogs received 2 doses of ropinirole, resulting in 79.7% that produced vomit. Overall, 74.2% of the dogs vomited all the expected ingested material. Average time to emesis was 11.0 minutes with 50% of dogs vomiting within 7 to 18 minutes. Adverse effects were observed for 17.0% of dog and were self-limiting. Ropinirole was less effective than apomorphine in inducing vomiting (91.4% ropinirole, 95.6% apomorphine [P < .0001]) and equally effective at evacuating all ingested material (74.2% ropinirole, 75.6% apomorphine [P = .245]).

CLINICAL RELEVANCE
Ropinirole ophthalmic solution is a safe and effective emetic for use in dogs. It has a small but statistically significant decrease in efficacy compared to IV apomorphine.
Human intravenous immunoglobulin use for hematological immune-mediated disease in dogs
Authors: Kane Briannan-Kym , Greer Ristan M. 
Published: April 2023

Abstract

OBJECTIVE
To report on survival rates and risk factors in dogs with immune-mediated hemolytic anemia (IMHA) and immune-mediated thrombocytopenia (ITP) treated with human IV immunoglobulin (hIVIG; Privigen). We hypothesized that hIVIG could be used as a salvage treatment to improve survival and reduce the requirement for ongoing blood transfusion therapy in IMHA and ITP patients.

ANIMALS
52 client-owned dogs with IMHA or ITP were included, comprising 31 females (28 spayed and 3 entire) and 21 males (19 castrated and 2 entire). Miniature Schnauzers were the most common breed (5), with a further 24 different breeds identified.

PROCEDURES
A retrospective cohort study was conducted between January 2006 and January 2022 that assessed the survival rates, risk factors, and need for ongoing transfusion in dogs with IMHA and ITP treated with hIVIG compared with those not receiving hIVIG.

RESULTS
Of 36 dogs that did not receive hIVIG, 29 (80%) survived and 7 (24%) died, and of 16 dogs administered hIVIG, 11 (69%) survived and 5 (31%) died (P = .56). No effect of PCV at admission or age on the risk of death was detected (OR, 1.00; 95% CI, 0.94 to 1.08; P = .89; and OR, 1.10; 95% CI, 0.85 to 1.47; P = .47, respectively).

CLINICAL RELEVANCE
This was the largest study to date of dogs with hematological immune-mediated disease treated with hIVIG. There was no difference in survival rates for dogs that received hIVIG versus those treated with standard immunosuppression. The benefit of hIVIG as a salvage treatment appears limited.
Training fatigue and recovery of Wushu Sanda athletes based on comprehensive environmental testing
Authors: Ren Yuanyuan 
Published: April 2023

Abstract
Wushu Sanda is a practical fighting skill and a new modern competitive event. Under certain conditions, they use kicking, hitting and wrestling as the main means according to certain rules. A good Sanda athlete should have good physical quality and special skills. Given the continuous change and revision of Sanda rules, the means to reduce the number of injuries sustained by athletes, tap their potential and prolong their sports life has become an urgent priority. During the training process, the coaches should use a guided and inspiring educational model to enable athletes to think positively and rationally. It is necessary to clearly understand the physical conditions of the body, combine the special characteristics of the Sanda movement and adopt effective prevention and recovery methods. This paper takes the sports fatigue of Sanda athletes as the research goal. To this end, we use physical, biochemical and psychological indicators and means to comprehensively monitor athletes’ sports fatigue. In order to improve martial arts training, improve the physical health of martial arts athletes and improve the athletes’ competitive level.
MAP kinase and plant–pathogen interactions govern male Zizania latifolia responses to Ustilago esculenta during the early stages of infection
Authors: Guo Pengfei , Zhou Huimin , Bai Longfei , Lin Yayu , Zhang Yalong , Wang Bichen , He Xiaomei , Gan Defang 
Published: April 2023

ABSTRACT
This study explored the effect of Ustilago esculenta infection on differentially expressed genes (DEGs) in male Manchurian wild rice (Zizania latifolia). We injected male Jiaobai plants at the five-leaf stage with U. esculenta suspension, and leaves at different timepoints after inoculation were collected for transcriptome sequencing. Transcriptome sequencing identified 1,226 DEGs mainly enriched in resistance-related processes. Weighted gene coexpression network analysis (WGCNA) showed that ‘plant–pathogen interaction’ and ‘MAPK signalling pathway-plant’ were the two most important upregulated pathways, and 16 candidate genes related to response to U. esculenta infection were screened. The results provide a basis for determining the molecular mechanisms of the response of male Z. latifolia to U. esculenta infection.
Animal models for large vessel vasculitis – The unmet need
Authors: Chu Cong-Qiu 
Published: April 2023

Abstract
Our understanding of the pathogenesis of large vessel vasculitis (LVV) are mainly achieved by studying the arteries taken from temporal artery biopsy in giant cell arteries (GCA) or surgical or autopsy specimens in Takayasu arteritis (TAK). These artery specimens provide invaluable information about pathological changes in these conditions that GCA and TAK are similar but are distinctly different in immune cell infiltrate and distribution of inflammatory cells in anatomical locations. However, these specimens of established arteritis do not provide information of the arteritis initiation and early events which are impossible to obtain in human artery specimens. Animal models for LVV are needed but not available. Here, several approaches are proposed for experimentation to generate animal models to aid in delineating the interaction of immune reaction with arterial wall components.
Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors: Sun Xiao-Jing , Li Zhi-Ying , Chen Min 
Published: April 2023

Abstract
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) encompasses a group of potentially life-threatening disorders characterized by necrotizing small vessel vasculitis with positive serum ANCA. To date, the pathogenesis of AAV has not been fully elucidated, but remarkable progress has been achieved in the past few decades. In this review, we summarize the mechanism of AAV. The pathogenesis of AAV involves various factors. ANCA, neutrophils, and the complement system play key roles in disease initiation and progression, forming a feedback amplification loop leading to vasculitic injury. Neutrophils activated by ANCA undergo respiratory burst and degranulation, as well as releasing neutrophils extracellular traps (NETs), thus causing damage to vascular endothelial cells. Activated neutrophils could further activate the alternative complement pathway, leading to the generation of complement 5a (C5a), which amplifies the inflammatory response by priming neutrophils for ANCA-mediated overactivation. Neutrophils stimulated with C5a and ANCA could also activate the coagulation system, generate thrombin, and subsequently cause platelet activation. These events in turn augment complement alternative pathway activation. Moreover, disturbed B-cell and T-cell immune homeostasis is also involved in disease development. In-depth investigation in pathogenesis of AAV might help to offer more effective targeted therapies.
MONOPOLISTIC PORT BUSINESS ACTIVITIES POST-DEMONOPOLIZATION OF PT.PELINDO (PERSERO) BASE ON BUSINESS COMPETITION LAW
Authors: Saleh Putu Samawati 
Published: April 2023

Since the implementation demonopolization of port business activities in 2008, the condition of Indonesian port business competition still dominates of PT.Pelindo (Persero) with market share od 84%. Even though the state has imposed a demonopolization policy with the aim of opening up opportunities for private port business entities to become competitors for PT.Pelindo (Persero). The monopolistic condition of PT Pelindo (Persero) is the reason to discuss in this paper. Finding mind problem in normative construction to get some solution are also be a purpose of this article. A normative juridical research and a statutory approach was carried out to find legally what was wrong in the port management mechanism. The expected results are in the form of normative improvement efforts that can be made in an effort to increase competition in port services, particularly in regards to restoring the role of port authorities and affirming the regulation of the separation of roles between port authorities and port business entities. This improvement is necessary, given the important role of ports as connectivity and mobility in Indonesia.
Short-term outcomes of bronchoplastic lobectomies performed from video-assisted thoracoscopic and thoracotomic approaches
Authors: Atyukov M. A. , Zemtsova I. Yu. , Petrov A. S. , Zhgemchugova-Zelenova O. A. , Novikova O. V. , Mischeryakov S. A. , Yablonskii P. K. 
Published: April 2023

The OBJECTIVE of this study was to evaluate the short-term outcomes of bronchoplastic lobectomies performed from video-assisted thoracoscopic (VATS) and thoracotomic approaches and to identify factors affecting the course of the early postoperative period.METHODS AND MATERIALS. Out of 398 patients underwent surgical resection in the Center for Intensive Pulmonology and Thoracic Surgery of the SPbSBHI «City multidisciplinary hospital № 2» from 2014 to 2021 for malignant lung neoplasms, 27 patients with bronchoplastic lobectomy were included in the retrospective study. Patients were divided into two groups depending on surgical approach: group I (n=17) included patients operated via thoracotomic approach; group II (n=10) included patients who underwent VATS surgeries. The groups were similar in gender, age, smoking history, Body Mass Index, concomitant pathology, functional status and stage of the disease. Surgical intervention included ipsilateral systematic lymph dissection and bronchoplastic lobectomy.RESULTS. There were no significant differences in time of operation, blood loss, duration of drainage of the pleural cavity, incidence of postoperative complications, length of hospital stay, number of dissected lymph nodes between the groups. Factor analysis of the influence of pre- and intraoperative factors on the development of postoperative complications showed that the risk of a complicated course of the postoperative period significantly decreased at normal values of FEV1 and FVC (OR=0.942, p<0.05; OR=0.932, p><0.05) and increased in the presence of adhesions (obliteration of the pleural cavity more than 50%), requiring total pneumolysis, and the absence of interlobar fissures (OR=5.5, p><0.05; OR=6.5, p><0.05). In multivariate analysis, strong adhesions in the pleural cavity turned out to be an independent unfavorable prognostic factor for the development of postoperative complications (OR=8.567, p><0.05). CONCLUSION. The use of VATS approach does not increase the incidence of complications after bronchoplastic lobectomies. In patients with FEV1>84.9 %)CONCLUSION. The use of VATS approach does not increase the incidence of complications after bronchoplastic lobectomies. In patients with FEV1>84.9 % and FVC>101.2 %, the risk of complications after bronchoplastic lobectomies is confirmed lower. Adhesions in pleural cavity requiring total pneumolysis is an independent unfavorable factor in the development of postoperative complications.
A Pharmacist-Assisted Initiative to Improve Chronic Pain Management and Reduce Opioid Use in Primary Care
Authors: Perry Kailene , Ferron Susan , Norquist Nathan , Mullen Deborah M. 
Published: April 2023

Background– Since publication of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain, there have been growing concerns that providers, including those in primary care, are tapering opioids too quickly and without concomitant use of non-opioid strategies for pain, leading to inadequate pain management. As a result, in November 2022 the CDC published Clinical Practice Guidelines for Prescribing Opioids for Pain, emphasizing the importance of creating comprehensive care plans for pain management and developing a consensual plan between provider and patient when tapering opioids.
Objective–Determine the impact of a pharmacist-assisted approach aimed at helping primary care providers minimize opioid use while improving management of chronic, non-malignant pain (CNMP).
Methods – This quality improvement project focused on one primary care provider partnering with a pharmacist to reassess the management of patients on long-term opioid therapy (LTOT) for CNMP. The intervention included a letter informing patients of the provider’s intent, pharmacist outreach to intervention patients, and pharmacist development of a patient registry, updated regularly with clinical data, recommendations, and outcomes for the provider to reference throughout the project. The intervention group was compared to patients prescribed opioids for CNMP by the remaining providers at the clinic who did not engage in the quality initiative.
Results – The intervention group had a mean effective daily morphine milligram equivalent (MME) reduction of 73.7% (17.2% control) after 18 months and 60% of patients discontinued opioids (14.3% control). In a subset of patients with functional assessment scores, 93.3% were either improved or unchanged, despite a 62.5% decrease in their mean effective daily MME. In both groups, one patient transferred care to a new provider.
Conclusions – With targeted recommendations and assistance from a pharmacist, a primary care provider can make significant progress in improving management of CNMP while reducing opioid prescribing.
Vacuum Arcs on Solar Array Surfaces
Authors: Vayner Boris , Ferguson Dale 
Published: April 2023

Arcs on the solar arrays appear to be the most plausible source for the electromagnetic radiation observed with the Arecibo radio telescope. In the laboratory, electrostatic discharges (arcs) on solar array coupons were studied in a simulated geosynchronous equatorial orbit environment. Arc current pulses were recorded with a high time resolution (up to 0.2 ns). Spectral properties of these pulses demonstrated no monotonic behavior but rather separated peaks within the frequency range of 100–1000 MHz. Electromagnetic radiation from these arcs was registered and recorded with a Yagi antenna 8 m distant from the arc site, and a high-speed oscilloscope. Analysis of the spectra resulted in the discovery of well-separated “lines.” Evaluation of arc current spectra and radio-frequency spectra revealed statistically significant patterns in the frequency domain. Measured radio fluxes and theoretical estimates of the power of electromagnetic radiation from arcs on spacecraft solar arrays strongly argue in favor of the arcing hypothesis for the source of this radiation. These results have enabled considerable progress to be made in understanding the physical nature of the generation of electromagnetic radiation by transient vacuum discharges.
TEKNIK PENANGANAN KOMPONEN SISA PADA OPERASI INDUSTRI PENANGKAPAN IKAN YANG BERBASIS DI PELABUHAN PERIKANAN PANTAI BLANAKAN
Authors: Mustaruddin  , Agustina Diana , Puspito Gondo , Baskoro Mulyono S. , Aini Syifa Nurul 
Published: April 2023

Penelitian bertujuan menganalisis keragaan komponen sisa dan menyusun teknik penanganannya pada operasi industri penangkapan ikan yang berbasis di PPP Blanakan. Metode yang digunakan adalah metode deskripsi, model PPA, dan analisis porsi tertimbang. Komponen sisa dari kelebihan stok perbekalan pada operasi industri penangkapan ikan adalah sisa BBM (rata-rata 38,5 l/kapal), sisa air tawar (rata-rata 117,5 l/kapal), dan sisa es balok (rata-rata 5,3 balok/kapal). Adapun komponen sisa dari dampak aktivitas operasi kapal adalah tumpahan BBM dan oli, serta sampah melaut, terutama kemasan plastik. Teknik produksi bersih untuk penanganan komponen sisa pada operasi industri penangkapan ikan yang berbasis di PPP Blanakan adalah (a) memberi pelatihan perencanaan cermat perbekalan BBM (rethink), (b) mengurangi perbekalan es balok (reduce), (c) penggunaan kembali sisa air tawar untuk membersihkan peralatan (reuse), (d) memperbaiki instalasi yang bocor (refine) dan memberi pelatihan peningkatan kesadaran akan dampak tumpahan BBM dan oli (rethink), dan (e) mengurangi perbekalan berkemasan plastik (reduce).
Kata kunci: air tawar, industri penangkapan ikan, komponen sisa, model PPA, pelabuhan perikanan, produksi bersih
Iodine Intake, UIE Levels, Nutritional Status and Academic Achievements in School-Age Children in Magelang, Central Java
Authors: Arika Romiza 
Published: April 2023

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>Iodine deficiency in school children is estimated at 25% worldwide. Complete brain development occurs at the age of 7 years and the development of cognitive function can be increased until 15 years with normally iodine status, namely adequate intake of iodine and Urinary Iodine Excretion (UIE). This study aims to analyze the relationship between iodine intake, UIE, height for age and academic achievements in school-age children. This research was an analytic observational study with a cross sectional design. This research was conducted in 4 elementary schools in Pakis District in March 2019. The samples were selected by random sampling, totaling 177 subjects. The dependent variable was the school's academic achievements in the form of midterm exam scores for maths, arts and sports. While the independent variables were iodine intake, UIE and height for age. The assessment of iodine intake was using a 24-hour recall form and interpreted using the 2007 Nutrisurvey application. The analysis method for UIE is the acid digestion method. Height for age is a child's nutritional status that can be determined based on anthropometric measurements. Academic achievements is learning outcomes as measured by midterm exam scores iin maths, arts, culture and sports. Data was analyzed by Linear Regression. Iodine intake increased math (b=0.01; p=0.014), art and sport (b=0.03; p=&lt;0.001) scores. UIE levels increased math (b=0.01; p=0.001), art (b=0.01; p=0.002) and sport (b=0.01; p=0.003) scores. Height for age increased sport scores (b=1.58; p=0.010). The conclusion of this study is that height for age increase sports ability and iodine intake also UIE can increase academic achievements.</em></p><p> </p></td></tr></tbody></table></div><strong><em>Keyword: Academic Achievements, Height for Age, Iodine Intake, UIE </em></strong>
Conhecimento de acadêmicos de Odontologia sobre o uso de anestésicos locais
Authors: Souza Alzemira Mascarenhas de , Oliveira Juliana Maria Souza de , Farias Kaliny Souza , Coêlho Anna Paula Silva , Pereira Juliana Vianna , Domingues José Eduardo Gomes , Conde Nikeila Chacon de Oliveira 
Published: April 2023

O presente estudo teve como objetivo avaliar o conhecimento de estudantes de graduação do curso de Odontologia em relação à indicação e uso dos anestésicos locais nos procedimentos clínicos e cirúrgicos. Trata-se de um estudo prospectivo, observacional tendo como instrumento de coleta um questionário composto de perguntas abertas e fechadas sobre a temática. Após assinatura do termo de consentimento livre e esclarecido, 59 acadêmicos que obedeciam aos critérios de inclusão e exclusão participaram do estudo respondendo ao questionário. A amostra apresentou média de idade de 22,75 anos, 17 (29,31%) eram do sexo masculino e 41 (70,68%) do feminino, sendo que um participante não declarou o sexo. A média de tempo cursando Odontologia foi de 4 anos, sendo que 19 alunos (31%) cursavam o 6º período, 22 (37,9%) o 8º período e 18 (31%) o 10º período do curso. Situações relacionadas à toxicidade do anestésico foram corretamente identificadas por 20 participantes (57,2% dos 35 que responderam à pergunta), 56 (94,9%) realizaram anamnese direcionada e 55 (93,2%) fizeram a escolha do sal anestésico de acordo com a condição sistêmica do paciente. Porém, quando questionados sobre a dose anestésica máxima em determinada situação clínica, apenas 6 (10,2%) responderam corretamente. Considerando a disponibilidade de anestésicos para uma exodontia simples em paciente hipertenso ou diabético controlado, gestante, lactante e criança, pouco mais que a metade dos alunos (62,7% a 52,5%) souberam indicar corretamente solução anestésica, considerando a lidocaína com vasoconstritor o anestésico de escolha. Foram observadas diferenças estatisticamente significativas quando comparado o gênero dos acadêmicos em relação ao uso de anestésico tópico (p=0,018) e uso de anestesia local para o procedimento de raspagem periodontal subgengival (p = 0,008), sendo as duas indicações mais comuns na parcela feminina da amostra. Conclui-se que a maioria dos acadêmicos possui conhecimentos necessários para escolha do sal anestésico e sucesso quanto ao emprego da técnica, entretanto não realizaram de forma correta o cálculo da dose máxima recomendada diante de uma situação clínica hipotética, necessitando, neste e em outros parâmetros, de revisão de conceitos, procedimentos e condutas clínicas.