bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Authors: Rodríguez-Carrio Javier , Burska Agata , Conaghan P G , Dik Willem A , Biesen Robert , Eloranta Maija-Leena , Cavalli Giulio , Visser Marianne , Boumpas Dimitrios T , Bertsias George , Wahren-Herlenius Marie , Rehwinkel Jan , Frémond Marie-Louise , Crow Mary K , Ronnblom Lars , Vital Ed , Versnel Marjan 
Published: March 2023

BackgroundType I interferons (IFN-I) contribute to a broad range of rheumatic and musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of IFN-I pathway activation may have clinical value. Although several IFN-I pathway assays have been proposed, the exact clinical applications are unclear. We summarise the evidence on the potential clinical utility of assays measuring IFN-I pathway activation.MethodsA systematic literature review was conducted across three databases to evaluate the use of IFN-I assays in diagnosis and monitor disease activity, prognosis, response to treatment and responsiveness to change in several RMDs.ResultsOf 366 screened, 276 studies were selected that reported the use of assays reflecting IFN-I pathway activation for disease diagnosis (n=188), assessment of disease activity (n=122), prognosis (n=20), response to treatment (n=23) and assay responsiveness (n=59). Immunoassays, quantitative PCR (qPCR) and microarrays were reported most frequently, while systemic lupus erythematosus (SLE), rheumatoid arthritis, myositis, systemic sclerosis and primary Sjögren’s syndrome were the most studied RMDs. The literature demonstrated significant heterogeneity in techniques, analytical conditions, risk of bias and application in diseases. Inadequate study designs and technical heterogeneity were the main limitations. IFN-I pathway activation was associated with disease activity and flare occurrence in SLE, but their incremental value was uncertain. IFN-I pathway activation may predict response to IFN-I targeting therapies and may predict response to different treatments.ConclusionsEvidence indicates potential clinical value of assays measuring IFN-I pathway activation in several RMDs, but assay harmonisation and clinical validation are urged. This review informs the EULAR points to consider for the measurement and reporting of IFN-I pathway assays.
Effectiveness of psychosocial interventions for pediatric patients with scoliosis: a systematic review
Authors: van Niekerk Maike , Richey Ann , Vorhies John , Wong Connie , Tileston Kali 
Published: March 2023

BackgroundPediatric patients affected by scoliosis have complex psychological and social care needs, and may benefit from psychosocial interventions. We therefore aimed to summarize evidence of the efficacy of psychosocial interventions for this patient population.MethodsLiterature was identified by searching Medline, PsycINFO, Embase, EBSCO Cumulated Index to Nursing and Allied Health Literature (CINAHL), and Cochrane Central Register of Controlled Trials (CENTRAL) from database inception to 20 March 2022. Articles that evaluated the effectiveness of psychosocial interventions for pediatric patients diagnosed with scoliosis and reported at least one quantitative outcome were included. Article eligibility, data extraction, and quality assessment (using the Cochrane Collaboration’s Risk of Bias Tool and Methodological Index for Non-Randomized Studies) were performed by two independent researchers. Findings are presented using narrative synthesis.ResultsWe identified ten studies, all of which focused on adolescent idiopathic scoliosis. Studies included a total of 1007 participants, most of whom were female. Three studies focused on patients undergoing bracing, six on patients undergoing spinal surgery, and one on patients broadly. Brace compliance monitoring and counseling were found to significantly improve brace compliance quality and quantity. Proactive mental healthcare delivery by nurses after spinal surgery was similarly found to improve outcomes. Several studies examined the efficacy of brief educational interventions; most did not report clear evidence of their efficacy. The methodological quality of studies was often unclear due to limitations in articles’ reporting quality.ConclusionsResearch on the efficacy of psychosocial interventions for pediatric patients with scoliosis is limited, with interventions involving frequent patient-provider interactions showing the most promise. Future clinical and research efforts should focus on developing and testing psychosocial interventions for this patient population, with emphasis on multidisciplinary teams delivering holistic care.Trial registration numberPROSPERO number CRD42022326957
Synthesis of 31-aminopyridinio–chlorophyll-a derivatives and their optical properties
Authors: Takarada Yuki , Hara Nobuyuki , Ogasawara Shin , Tamiaki Hitoshi 
Published: March 2023

Oxidative reactions of isomeric amino-, methylamino-, and dimethylamino-pyridines with the 3-vinyl group of methyl pyropheophorbide-[Formula: see text], a chlorophyll-[Formula: see text] derivative, afforded 3-{1-[[Formula: see text]/[Formula: see text]/[Formula: see text]-(non/mono/di-methyl-amino)pyridinio]ethenyl}chlorins bearing the C31–N+ bond. Although all the [Formula: see text]/[Formula: see text]-substituents gave almost the same visible absorption spectra in acetonitrile, the [Formula: see text]-methylation effect on the Qy maxima was observed in the [Formula: see text]-substituted analogs with blue-shifted absorption bands. The substitution with most of the amino moieties suppressed the intramolecular electron transfer from the photoexcited chlorin core to the relatively electron-rich pyridinio periphery to enhance the fluorescence emission in acetonitrile, compared with the unsubstituted pyridinio analog. By contrast, the [Formula: see text]-NH2 substituted pyridine–chlorin conjugate was less fluorescent than any other aminated analogs as well as the unsubstituted counterpart. The electron-donating ability of the [Formula: see text]-NH2 group was recovered by the addition of alcohols to give highly fluorescent species.
Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma
Authors: Yeo Alan T. , Shah Rushil , Aliazis Konstantinos , Pal Rinku , Xu Tuoye , Zhang Piyan , Rawal Shruti , Rose Christopher M. , Varn Frederick S. , Appleman Vicky A. , Yoon Joon , Varma Hemant , Gygi Steven P. , Verhaak Roel G.W. , Boussiotis Vassiliki A. , Charest Al 
Published: March 2023

Abstract
The composition of the tumor immune microenvironment (TIME) is considered a key determinant of patients’ response to immunotherapy. The mechanisms underlying TIME formation and development over time are poorly understood. Glioblastoma (GBM) is a lethal primary brain cancer for which there are no curative treatments. GBMs are immunologically heterogeneous and impervious to checkpoint blockade immunotherapies. Utilizing clinically relevant genetic mouse models of GBM, we identified distinct immune landscapes associated with expression of EGFR wild-type and mutant EGFRvIII cancer driver mutations. Over time, accumulation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) was more pronounced in EGFRvIII-driven GBMs and was correlated with resistance to PD-1 and CTLA-4 combination checkpoint blockade immunotherapy. We determined that GBM-secreted CXCL1/2/3 and PMN-MDSC–expressed CXCR2 formed an axis regulating output of PMN-MDSCs from the bone marrow leading to systemic increase in these cells in the spleen and GBM tumor-draining lymph nodes. Pharmacologic targeting of this axis induced a systemic decrease in the numbers of PMN-MDSC, facilitated responses to PD-1 and CTLA-4 combination checkpoint blocking immunotherapy, and prolonged survival in mice bearing EGFRvIII-driven GBM. Our results uncover a relationship between cancer driver mutations, TIME composition, and sensitivity to checkpoint blockade in GBM and support the stratification of patients with GBM for checkpoint blockade therapy based on integrated genotypic and immunologic profiles.
Differences in Myocardial Remodeling and Tissue Characteristics in Chronic Isolated Aortic and Mitral Regurgitation
Authors: Malahfji Maan , Kitkungvan Danai , Senapati Alpana , Nguyen Duc T. , El-Tallawi Carlos , Tayal Bhupendar , Debs Dany , Crudo Valentina , Graviss Edward A. , Reardon Michael J. , Quinones Miguel , Zoghbi William A. , Shah Dipan J. 
Published: March 2023

Background:
The left ventricular hemodynamic load differs between aortic regurgitation (AR) and primary mitral regurgitation (MR). We used cardiac magnetic resonance to compare left ventricular remodeling patterns, systemic forward stroke volume, and tissue characteristics between patients with isolated AR and isolated MR.

Methods:
We assessed remodeling parameters across the spectrum of regurgitant volume. Left ventricular volumes and mass were compared against normal values for age and sex. We calculated forward stroke volume (planimetered left ventricular stroke volume−regurgitant volume) and derived a cardiac magnetic resonance–based systemic cardiac index. We assessed symptom status according to remodeling patterns. We also evaluated the prevalence of myocardial scarring using late gadolinium enhancement imaging, and the extent of interstitial expansion via extracellular volume fraction.

Results:

We studied 664 patients (240 AR, 424 primary MR), median age of 60.7 (49.5–69.9) years. AR led to more pronounced increases in ventricular volume and mass compared with MR across the spectrum of regurgitant volume (
P
<0.001). In ≥moderate regurgitation, AR patients had a higher prevalence of eccentric hypertrophy (58.3% versus 17.5% in MR;
P
<0.001), whereas MR patients had normal geometry (56.7%) followed by myocardial thinning with low mass/volume ratio (18.4%). The patterns of eccentric hypertrophy and myocardial thinning were more common in symptomatic AR and MR patients (
P
<0.001). Systemic cardiac index remained unchanged across the spectrum of AR, whereas it progressively declined with increasing MR volume. Patients with MR had a higher prevalence of myocardial scarring and higher extracellular volume with increasing regurgitant volume (
P
value for trend <0.001), whereas they were unchanged across the spectrum of AR (
P
=0.24 and 0.42, respectively).

Conclusions:
Cardiac magnetic resonance identified significant heterogeneity in remodeling patterns and tissue characteristics at matched degrees of AR and MR. Further research is needed to examine if these differences impact reverse remodeling and clinical outcomes after intervention.
Early-Life Cardiovascular Risk Factor Trajectories and Vascular Aging in Midlife: A 30-Year Prospective Cohort Study
Authors: Wang Yang , Wang Jie , Zheng Xiao-Wei , Du Ming-Fei , Zhang Xi , Chu Chao , Wang Dan , Liao Yue-Yuan , Ma Qiong , Jia Hao , Hu Gui-Lin , Yan Yu , Sun Yue , Chen Chen , Zhang Xiao-Yu , Li Hao , Zou Ting , Niu Ze-Jiaxin , Man Zi-Yue , Wang Lan , Luo Wen-Jing , Wu Guan-Ji , Kang Yu-Ming , Chang John , Delles Christian , Lu Yao , Mu Jian-Jun 
Published: March 2023

Background:
Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations of individual cardiovascular risk factors from childhood to midlife and their accumulation over a 30-year span with vascular aging in midlife.

Methods:
Using data from the ongoing cohort of Hanzhong Adolescent Hypertension study, 2180 participants aged 6 to 18 years at baseline were followed for over 30 years. Distinct trajectories of systolic blood pressure (SBP), body mass index (BMI), and heart rate from childhood to midlife were identified by group-based trajectory modeling. Vascular aging was assessed by carotid intima media thickness or brachial-ankle pulse wave velocity.

Results:
We identified 4 distinct SBP trajectories, 3 distinct BMI trajectories, and 2 distinct heart rate trajectories from childhood to midlife. Persistently increasing SBP, high-increasing BMI, and high-stable heart rate were all shown to have a positive association with brachial-ankle pulse wave velocity in midlife. For carotid intima–media thickness, similar associations were observed for persistently increasing SBP and high-increasing body mass index. After further adjustment for SBP, body mass index and heart rate at the time of vascular assessment in 2017, associations were also observed for cardiovascular risk factor trajectories accumulation with brachial-ankle pulse wave velocity (β, 0.656 [95% CI, 0.265–1.047]) and with carotid intima media thickness (β, 0.045 [95% CI, 0.011–0.079]) in adulthood.

Conclusions:
Longitudinal exposure to individual cardiovascular risk factors from childhood to midlife and cardiovascular risk factor accumulation were associated with an increased risk of vascular aging in midlife. Our study lends support for early targeting of risk factors in order to prevent cardiovascular disease later in life.
The Indochinese Communist Party's Unfinished Revolution of 1945 and the Origins of Vietnam's 30-Year Civil War
Authors: Asselin Pierre 
Published: March 2023

Abstract
This article examines the genesis and outcomes of the so-called August Revolution undertaken by the Indochinese Communist Party (ICP) in 1945. Drawing on Vietnamese archival materials and ICP resolutions, instructions, and assessments, the article shows that the revolution did not culminate in ICP dominance of Vietnamese politics and that Chinese Nationalist occupation authorities in northern Vietnam were neither cordial nor obliging toward the government established by Ho Chi Minh after he declared Vietnam's independence on 2 September 1945. The so-called bourgeois revolution Ho and the ICP instigated that summer faced insurmountable challenges, including domestic fracturing and contestation, that precluded its swift completion. The August Revolution that inspired Ho's declaration of independence marked the beginning of a bloody internal struggle for power in Vietnam, not its culmination.
A Shadow Party System: The Political Activities of Cold War Polish Exiles
Authors: Łukasiewicz Sławomir 
Published: March 2023

Abstract
Polish émigrés were an important feature of the Cold War landscape in Europe, as were exiles from other Central European countries. In addition to opposing the Communist systems in their countries of origin, they tried to pursue independent policies in the West. Émigrés were active in political parties—including Christian Democratic, Socialist, and agrarian parties—but at the same time they attempted to create new forms, such as new political and social movements and transnational organizations. With active international agendas, they also worked to influence their own societies, both in the countries in which they had settled and in their countries of origin. This mixture of social and political dimensions was a specific phenomenon of Cold War intellectual history in Europe. The article draws on archival materials from Poland, Great Britain, France, Italy, and the United States and builds on concepts developed by scholars such as Maurice Duverger, Giovanni Sartori, V. O. Key, Jr., Yossi Shain, and Idesbald Goddeeris.
U.S. Cold War Policy and the Italian Far-Right: The Nixon Administration, Republican Party Operatives, and the Borghese Coup Plot of 1970
Authors: Marshall Jonathan 
Published: March 2023

Abstract
The Nixon administration's attempt to promote a military coup in Chile after the election of a far-left president in September 1970 is a well-documented example of U.S. officials’ willingness do whatever was needed to curtail Soviet influence in the Third World. Drawing on declassified White House documents and records of the U.S. Central Intelligence Agency, this article examines the parallel but largely unknown story of U.S. dealings with right-wing extremists in one of the founding members of the North Atlantic Treaty Organization, Italy, at around that same time. In December 1970, far-right activists in Italy staged an abortive coup that was intended to prevent further gains by Italy's leftist parties. The article draws on new and widely forgotten sources to examine the background and involvement of two private U.S. operatives for the Republican Party who were closely aligned with senior coup plotters in Italy. Their involvement with Italian neo-fascists should raise concerns about the dangers of private meddling in foreign policy and the potential for private actors to create misperceptions about critical U.S. government policies.
Making the Alliance for Progress Serve the Few: U.S. Economic Aid to Cold War Brazil (1961–1964)
Authors: Loureiro Felipe P. 
Published: March 2023

Abstract
This article analyzes the aid provided by U.S. and multilateral institutions to Brazilian states during the government of João Goulart in Brazil (1961–1964). Although scholars have long emphasized that John F. Kennedy's Alliance for Progress employed state-by-state shaped by Cold War goals that helped to destabilize Brazil's political system and to facilitate the advent of a military regime that lasted 21 years, little has been known until now about the amount, characteristics, and impact of these loans. This article presents the first comprehensive list of U.S. dollar loans and cruzeiro grants to Brazilian states during this crucial period of Brazil's history and demonstrates that U.S. aid was strongly guided by political objectives, particularly boosting anti-Communist and pro-U.S. governors for the forthcoming Brazilian presidential elections. Officials in Washington were hoping to keep strategic Brazilian states under U.S. influence in case a military move against Goulart proved necessary.
Different strokes for different folks? The translation of public values into official meanings
Authors: Wæraas Arild , Sataøen Hogne Lerøy 
Published: March 2023

It is well known that the meanings of public values can vary significantly across different settings, given their abstract nature. Despite this knowledge, however, the public values literature has not significantly examined the official meanings of public values in their local setting. Against this backdrop, on the basis of a translation perspective we examine the context-specific meanings of 219 public values as defined by the core values statements of 61 Nordic central government agencies. We show variation and patterns in the meanings, emphasizing how the meanings vary depending on whether the values are translated into (1) a work and service delivery theme, (2) an internal relations theme and (3) an external relations theme. Through these findings, the study highlights the importance of taking into consideration the official meanings of agency core values for understanding the relationship between public values and administrative behaviour. Points for practitioners The findings from this study inform public managers and administrators of the possible variation in the official meanings that could be attributed to core values. They suggest that public managers should carefully consider how they want their agency's core values to be understood by the employees. Specifically, when translating core values, public managers are advised to assess whether the signifiers they use to translate the values should guide work and service delivery, internal relations or external relations, respectively, or a combination. By drawing attention to the intended meanings of core values, the findings create increased awareness of how different translations of core values implicate different administrative behaviours.
GEospatial aNalysis of ExtRacorporeal membrane oxygenATion in Europe (GENERATE)
Authors: Gillon Stuart , Zheng Chunyu , Feng Zhiqiang , Fleig Marcel , Scquizzato Tommaso , Belohlavek Jan , Lorusso Roberto , Lone Nazir , Swol Justyna 
Published: March 2023

Introduction A cross-sectional survey GENERATE (GEospatial aNalysis of ExtRacorporeal membrane oxygenATion in Europe) initiated on behalf of the European chapter of the Extracorporeal Life Support Organization (EuroELSO), aims to provide a systematic, detailed description of contemporary Extracorporeal Life Support (ECLS) provision in Europe, map the spatial distribution of ECLS centers, and the accessibility of ECLS. Methods Structured data collection forms were used to create a narrative description of ECLS provision in EuroELSO affiliated countries. This consisted of both center-specific data and relevant national infrastructure. Data was provided by a network of local and national representatives. Spatial accessibility analysis was conducted where appropriate geographical data were available. Results 281 centers from 37 countries affiliated to EuroELSO were included in the geospatial analysis and demonstrate heterogeneous patterns of ECLS provision. Accessibility of ECLS services within 1 hour of drive-time is available for 50% of the adult population in 8 of 37 countries (21.6%). This proportion is reached within 2 hours in 21 of 37 countries (56.8%) and within 3 hours in 24 of 37 countries (64.9%). For pediatric centers, accessibility is similar with 9 of 37 countries (24.3%) reached the covering of 50% of the population aged 0–14 within 1 hour and 23 of 37 countries (62.2%) within 2 hours and 3 hours. Conclusions ECLS services are accessible in most of the European countries, but their provision differs across the continent. There is still no solid evidence given regarding the optimal ECLS provision model. The spatial disparity in ECLS provision demonstrated in our analysis requires governments, healthcare professionals and policy makers to consider how to develop existing provision to accommodate the anticipated increase in need for time critical access to this advanced support modality.
Primary neonatal and pediatric ECMO transport: First experience in Spain
Authors: Belda Hofheinz Sylvia , López Fernández Eduardo , García Torres Enrique , Arias Dachary Javier , Boni Lorenzo , Tajuelo Llopis Imanol , Orozco Gámez Rocío , Carballo Rodríguez Lorena , Martins Bravo María , López Gámez Susana , García Maellas Maite , Gijón Mediavilla Manuel 
Published: March 2023

Introduction The organization of primary Extracorporeal membrane oxygenation (ECMO) transport is highly variable. Methods To present the experience of the first mobile pediatric ECMO program in Spain, we designed a prospective descriptive study of all primary neonatal and pediatric (0–16 years) ECMO transports carried out over 10 years. The main variables recorded include demographic information, patient background, clinical data, ECMO indications, adverse events, and main outcomes. Results 39 primary ECMO transports were carried out with a 66.7% survival to hospital discharge. The median age was 1.24 months[IQR: 0.09–96]. Cannulation was mostly peripheral venoarterial (33/39). The mean response time from the call from the sending center to the departure of the ECMO team was 4 h[2.2–8]. The median inotropic score at the time of cannulation was 70[17.2–206.5], with a median oxygenation index of 40.5[29–65]. In 10% of the cases, ECMO-CPR was performed. Adverse events occurred in 56.4%, mostly related to the means of transport (40% overall). On arrival at the ECMO center, 44% of the patients underwent interventions. The median PICU stay was 20.5 days[11–32]. 5 patients developed neurological sequels. Statistically significant differences between survivors and deceased patients were not found. Conclusions A good survival rate, with a low prevalence of serious adverse events, suggests a clear benefit of primary ECMO transport when conventional therapeutic measures are exhausted and the patient is too unstable to undergo conventional transport. A nationwide primary ECMO-transport program must therefore be offered to all patients regardless of their location.