bluuebunny/crossref_metadata_2025_split huggingface dataset:
Components of micro-evolutionary and phenotypic change in seasonal migration versus residence in a wild population
Authors: Acker Paul , Daunt Francis , Wanless Sarah , Burthe Sarah J. , Newell Mark A. , Harris Michael P. , Swann Robert L. , Gunn Carrie , Morley Tim I. , Reid Jane M. 
Published: December 2022

ABSTRACTDissecting joint micro-evolutionary and plastic responses to environmental perturbations fundamentally requires quantifying interacting components of genetic and environmental variation underlying expression of key traits. This ambition is particularly challenging for phenotypically discrete traits where multiscale decompositions are required to handle non-linear transformations of underlying genetic and environmental variation into phenotypic variation, especially when effects have to be estimated from incomplete field observations. We devised a novel joint multistate capture-recapture and quantitative genetic animal model, and fitted this model to full-annual-cycle resighting data from partially migratory European shags (Gulosus aristotelis) to estimate key components of genetic, environmental and phenotypic variance in the ecologically critical discrete trait of seasonal migration versus residence. We demonstrate non-trivial additive genetic variance in latent liability for migration, resulting in estimated micro-evolutionary responses following two episodes of strong survival selection. Yet, underlying additive genetic effects interacted with substantial permanent individual and temporary environmental effects to generate complex non-additive effects, causing large intrinsic gene-by-environment interaction variance in phenotypic expression. Our findings reveal how temporal dynamics of seasonal migration result from combinations of instantaneous micro-evolution and within-individual phenotypic inertia, and highlight how plastic phenotypic variation could expose cryptic genetic variation underlying discrete traits to complex forms of selection.
A bubble in the making: symbolic boundaries in a Finnish expatriate community
Authors: Peltonen Tuomo , Huhtinen Sirkka-Liisa 
Published: December 2022

PurposeWhile there is anecdotal evidence that internationally mobile workers often form isolated nation-based communities or “expatriate bubbles,” previous academic scholarship on the expatriate communities and their subjective boundaries is limited. The primary purpose of this article is to advance the theoretical or conceptual understanding of expatriate communities as bubbles.Design/methodology/approachAs developed by Lamont and Molnár (2002), the theory of symbolic boundaries is applied and set to scrutinize the production and maintenance of insulated expatriate communities. Empirically, an ethnographic study of a community of Finnish expatriates in a Southeast Asian country is undertaken to describe how symbolic boundaries are constructed.FindingsThe main theoretical implication of the paper is the recognition that expatriates themselves are involved in creating the “bubble.” The boundaries separating the national expatriate community are not externally imposed but can be viewed as consequences of the active boundary work of the expatriates. The empirical study demonstrates how the Finnish expatriates negotiated the symbolic boundaries of their community, drawing on cultural, moral and spatial modalities in different levels of boundary work.Originality/valueThere need to be more systematic attempts to develop a theoretically grounded understanding of insulated expatriate communities and their boundaries. This article contributes to the sociological conceptualization of expatriate bubbles by utilizing the symbolic boundary approach, which adds perspective to the embryonic theory of the subjective boundaries of expatriate communities. The multiplicity of different types of symbolic boundaries and their modalities suggests that an expatriate bubble is rarely a finished state or structure.
Rethinking Accounting, Accountability, and Accounting Regulation: Concerns about the Proposed Canadian Sustainability Standards Board*
Authors: Cooper David J. , Everett Jeff , Himick Darlene , Senkl Daniela 
Published: December 2022

AbstractThis paper expands on a letter recently submitted by a group of Canadian business academics to the Independent Review Committee on Standard Setting in Canada (IRCSSC) in response to the committee's proposed Canadian Sustainability Standards Board. We highlight sections of the IRCSSC's Consultation Paper that we find problematic and draw on accounting and other research to explain why it fails to live up to its potential. Chief among the problems we identify is that the IRCSSC appears to be wedded to the same narrow, investor‐based focus promoted by the International Sustainability Standard Board. We also draw attention to the rushed nature of the process, its exclusion of lay experts, the IRCSSC's ambiguous use of the term public interest, and its inattention to alternative understandings of value and the environment (including the people within it). Finally, we problematize the IRCSSC's sidestepping of the issues of power, culture, and conflict; its neglect of monitoring and enforcement; and its surprising disregard of the Global Reporting Initiative. Along with a number of suggestions for improving the process and its outcome, this paper also contributes to ongoing debates on standard setting and the question of whether accounting is currently equipped to provide the necessary tools for sustainability reporting.
Acute effects of lithium augmentation on the kidney in geriatric compared with non‐geriatric patients with treatment‐resistant depression
Authors: Osterland Sarah Luise , Adli Mazda , Saritas Turgay , Schlattmann Peter , Behr Joachim , Müller‐Mertel Ronja , Hoffmann Kai , Stamm Thomas J. , Bschor Tom , Richter Christoph , Steinacher Bruno , Jockers‐Scherübl Maria‐Christiane , Köhler Stephan , Heinz Andreas , Ricken Roland , Buspavanich Pichit 
Published: December 2022

AbstractIntroductionLithium augmentation (LA) of antidepressants is a first‐line therapy option for treatment‐resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients mostly because of the fear of kidney toxicity. The purpose of this study is to investigate estimated glomerular filtration rate (eGFR) changes and number of acute kidney injuries (AKI) using LA in geriatric compared with non‐geriatric patients.MethodsIn a prospective multicenter cohort study, eGFR changes were measured in 201 patients with unipolar depression (nage≥65years = 29; nage<65years = 172) at baseline and over 2–6 weeks of LA. We used linear mixed models to investigate changes in eGFR upon LA and assessed the number of AKIs, according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.ResultsBoth age groups showed a significant eGFR decline over the course of treatment with lower eGFR in geriatric patients. The lithium serum level (interpretable as “effect of LA”) had a significant effect on eGFR decline. Both effects (age group and lithium serum level) on eGFR decline did not influence each other, meaning the effect of LA on eGFR decline did not differ between age groups. Two AKIs were observed in the geriatric age group when serum lithium levels exceeded the therapeutic range of >0.8 mmol/L.ConclusionThis is the first study investigating eGFR change and AKI upon LA for TRD in geriatric compared with non‐geriatric patients. Our data suggest that LA, as an effective treatment option in geriatric patients, should be closely monitored to avoid AKIs.
Systematic review with network meta‐analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease
Authors: Din Shahida , Selinger Christian P. , Black Christopher J. , Ford Alexander C. 
Published: December 2022

SummaryBackgroundBiologics and small molecules for inflammatory bowel disease (IBD) may increase infection risk. Herpes zoster causes acute and long‐term symptoms, but vaccination is not recommended in patients with IBD, unless >50 years of age.AimsTo examine risk of Herpes zoster infection with all licensed biologics and small molecules for IBD using network meta‐analysis.MethodsWe searched the literature to 4th October 2022, for randomised controlled trials of these drugs in luminal Crohn's disease or ulcerative colitis reporting data on occurrence of Herpes zoster infection during follow‐up. We used a frequentist approach and a random effects model, pooling data as relative risks (RRs) with 95% confidence intervals (CIs).ResultsWe identified 25 trials (9935 patients). Only tofacitinib 10 mg b.d. (RR = 6.90; 95% CI 1.56–30.63, number needed to harm (NNH) = 97; 95% CI 19–1022) and upadacitinib 45 mg o.d. (RR = 7.89; 95% CI 1.04–59.59, NNH = 83; 95% CI 10–14,305) were significantly more likely to increase risk of Herpes zoster infection. Janus kinase inhibitors were the most likely drug class to increase risk of infection, and risk increased with higher doses (RR with lowest dose = 3.16; 95% CI 1.02–9.84, NNH = 265; 95% CI 65–28,610, RR with higher dose = 5.91; 95% CI 2.21–15.82, NNH = 117; 95% CI 39–473).ConclusionsIn a network meta‐analysis, the janus kinase inhibitor tofacitinib, and all janus kinase inhibitors considered as a class, were most likely to increase risk of Herpes zoster infection. Risk increased with higher doses.
Association between use of febuxostat and muscle injury: A disproportionality analysis and meta‐analysis of randomized controlled trials
Authors: Mitsuboshi Satoru , Kotake Kazumasa 
Published: December 2022

AimsSeveral reports have suggested an association between febuxostat and muscle injury. The purpose of this study was to determine whether febuxostat increases the risk of muscle injury. This study included an analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS) database and a systematic review/meta‐analysis of randomized controlled trials.MethodsFirst, evaluation of the FAERS data included a disproportionality analysis that compared patients with and without rhabdomyolysis according to whether they were receiving febuxostat or allopurinol. Second, a systematic review/meta‐analysis was performed to assess the risk of rhabdomyolysis and muscle injury in patients who used febuxostat or allopurinol.ResultsAnalysis of the FAERS data revealed disproportionality for increasing rhabdomyolysis in patients who received febuxostat (reporting odds ratio 4.49, 95% confidence interval [CI] 3.72–5.38, P < .01) and allopurinol (reporting odds ratio 2.49, 95% CI 2.25–2.75, P < .01). Nineteen studies were eligible for inclusion in the systematic review/meta‐analysis. Rhabdomyolysis was reported in only 1 study. The risk of any type of muscle damage was not significantly increased with febuxostat compared with placebo (risk ratio 0.92, 95% CI 0.73–1.17, P = .52, I2 = 0%; 8 studies including 2597 participants, high‐certainty evidence) or allopurinol (risk ratio 1.03, 95% CI 0.94–1.11, P = .56, I2 = 0%; 9 studies including 17 644 participants, moderate‐certainty evidence).ConclusionFebuxostat does not seem to affect the risk of muscle injury. However, the findings of this meta‐analysis indicate a need for further high‐quality observational studies with long‐term follow‐up.
Endogenous testosterone concentrations and muscle mass, strength and performance in women, a systematic review of observational studies
Authors: Taylor Sasha , Islam Rakibul M. , Bell Robin J. , Hemachandra Chandima , Davis Susan R. 
Published: December 2022

AbstractObjectiveTo explore the associations between endogenous testosterone blood concentrations and muscle mass, strength and performance in community dwelling women.Design, Patients and MeasurementsOnline databases, including Ovid MEDLINE, EMBASE and Web of Science, were searched for observational studies, with at least 100 female participants, reporting associations between endogenous testosterone blood concentrations and muscle mass, strength and performance. The findings were synthesized in a narrative review. Heterogeneity in study design and analysis precluded a meta‐analysis.ResultsOf the 36 articles retrieved for full‐text review, 10 met the inclusion criteria. Eight studies were cross‐sectional, 1 longitudinal and 1 provided both cross‐sectional and longitudinal data. Testosterone was measured by liquid chromatography‐tandem mass spectrometry in two studies and by immunoassay in 8. An association between total testosterone and muscle mass, strength or performance in women was not found. The studies of calculated free or bioavailable testosterone and lean muscle mass reported a positive association, but no association was reported for muscle strength or performance. Each included study was limited by a high risk of bias in at least one assessed domain.ConclusionsThis review does not support an association between testosterone and muscle mass, strength or performance in women. This, together with the reported associations between free or bioavailable testosterone and muscle mass should be interpreted cautiously due to the predominant use of immunoassay and the inaccuracy of calculated variables. Additionally, biological significance of nonprotein bound testosterone has not been established. Further studies examining the relationship between precisely measured testosterone and muscle mass and function in women are required.
Decoding the contributions of gut microbiota and cerebral metabolism in acute liver injury mice with and without cognitive dysfunction
Authors: Sun Tianning , Du Hongying , Li Zhen , Xiong Jun , Liu Yanbo , Li Yujuan , Zhang Wencui , Liang Fangyuan , He Jingang , Liu Xiaodong , Xiang Hongbing 
Published: December 2022

AbstractAimsPatients with acute liver injury (ALI) can develop cognitive dysfunction (CD). The study investigated the role of gut microbiota and cerebral metabolism in ALI mice with and without CD.MethodsMale C57BL/6 mice that received thioacetamide were classified into ALI mice with (susceptible) or without (unsusceptible) CD‐like phenotypes by hierarchical cluster analysis of behavior. The role of gut microbiota was investigated by 16S ribosomal RNA gene sequencing and feces microbiota transplantation (FMT). 1H‐[13C] NMR and electrophysiology were used to detect the changes in cerebral neurotransmitter metabolic and synaptic transition in neurons or astrocytes.ResultsApromixlay 55% (11/20) of mice developed CD and FMT from the susceptible group transmitted CD to gut microbiota‐depleted mice. Alloprevotella was enriched in the susceptible group. GABA production was decreased in the frontal cortex, while hippocampal glutamine was increased in the susceptible group. Altered Escherichia. Shigella and Alloprevotella were correlated with behaviors and cerebral metabolic kinetics and identified as good predictors of ALI‐induced CD. The frequencies of both miniature inhibitory and excitatory postsynaptic currents in hippocampal CA1 and prefrontal cortex were decreased in the susceptible group.ConclusionAltered transmitter metabolism and synaptic transmission in the hippocampus and prefrontal cortex and gut microbiota disturbance may lead to ALI‐induced CD.
Descriptive analysis evaluating the use of direct oral anticoagulation therapy in heart and lung transplant recipients
Authors: Rubido Eric D. , Cooper Megan H. , Donahue Kevin R. , Krisl Jill 
Published: December 2022

AbstractBackgroundDirect oral anticoagulants (DOACs) are widely utilized following cardiothoracic transplantation with limited guidance regarding drug–drug interactions (DDIs), periprocedural management, and DOAC‐specific monitoring.MethodsWe performed a single‐center, retrospective, descriptive analysis of adult cardiothoracic transplant recipients initiated on DOAC therapy between May 2016 and July 2021. The primary endpoint for this analysis was the percentage of patients dosed per package labeling. Secondary endpoints included DOAC prescribing in the context of DDIs, renal dysfunction, and periprocedural management, as well as thromboembolism and major bleeding at 12 months.ResultsA total of 125 patients were included in this analysis with a median age of 62 years. At initiation, 63.2% of patients were dosed according to package labeling. The most common reason for non‐labeled dosing was concomitant azole antifungal therapy. DOAC therapy was held for 82 procedures with no reported thrombotic events and one major bleed in the setting of AKI. Hemodialysis‐dependence was associated with a reduced risk of thrombosis (0 vs. 10 events per 100 PY, p = .002) and an increased risk of major bleeding (23 vs. 8 events per 100 PY, p = .006). Additionally, DOAC‐specific anti‐xa guided dosing was associated with a reduced risk of major bleeding (0 vs. 13 events per 100 PY, p < .001).ConclusionOur findings show that deviation from package labeling is common following cardiothoracic transplantation and its association with clinical outcomes warrants further study.
Musical coordination affects children's perspective‐taking, but musical synchrony does not
Authors: Wan Yingjia , Wei Yipu , Xu Baorui , Zhu Liqi , Tanenhaus Michael K. 
Published: December 2022

AbstractPerspective‐taking, which is important for communication and social activities, can be cultivated through joint actions, including musical activities in children. We examined how rhythmic activities requiring coordination affect perspective‐taking in a referential communication task with 100 Chinese 4‐ to 6‐year‐old children. In Study 1, 5‐ to 6‐year‐old children played an instrument with a virtual partner in one of three coordination conditions: synchrony, asynchrony, and antiphase synchrony. Eye movements were then monitored with the partner giving instructions to identify a shape referent which included a pre‐nominal scalar adjective (e.g., big cubic block). When the target contrast (a small cubic block) was in the shared ground and a competitor contrast was occluded for the partner, participants who used perspective differences could, in principle, identify the intended referent before the shape was named. We hypothesized that asynchronous and antiphase synchronous musical activities, which require self‐other distinction, might have stronger effects on perspective‐taking than synchronous activity. Children in the asynchrony and antiphase synchrony conditions, but not the synchrony condition, showed anticipatory looks at the target, demonstrating real‐time use of the partner's perspective. Study 2 was conducted to determine if asynchrony and antiphase asynchrony resulted in perspective‐taking that otherwise would not have been observed, or if synchronous coordination inhibited perspective‐taking that would otherwise have occurred. We found no evidence for online perspective‐taking in 4‐ to 6‐year‐old children without music manipulation. Therefore, playing instruments asynchronously or in alternation, but not synchronously, increases perspective‐taking in children of this age, likely by training self‐other distinction and control. A video abstract of this article can be viewed at https://youtu.be/TM9h_GpFlsA.Research Highlights
This study is the first to show that rhythmic coordination, a form of non‐linguistic interaction, can affect children's performance in a subsequent linguistic task.
Eye‐movement data revealed that children's perspective‐taking in language processing was facilitated by prior asynchronous and antiphase synchronous musical interactions, but not by synchronous coordination.
The results challenge the common “similar is better” view, suggesting that maintaining self‐other distinction may benefit social interactions that involve representing individual differences.
Respiratory function in uncomplicated type 1 diabetes: Blunted during exercise even though normal at rest!
Authors: Jlali Islem , Heyman Elsa , Matran Régis , Marais Gaelle , Descatoire Aurélien , Rabasa‐Lhoret Rémi , Touil Imen , Pawlak‐Chaouch Mehdi , Mucci Patrick , Fontaine Pierre , Baquet Georges , Tagougui Sémah 
Published: December 2022

AbstractAimsType 1 diabetes is associated with a substantially increased risk of impaired lung function, which may impair aerobic fitness. We therefore aimed to examine the ventilatory response during maximal exercise and the pulmonary diffusion capacity function at rest in individuals with uncomplicated type 1 diabetes.MethodsIn all, 17 adults with type 1 diabetes free from micro–macrovascular complications (glycated haemoglobin: 8.0 ± 1.3%), and 17 non‐diabetic adults, carefully matched to the type 1 diabetes group according to gender, age, level of physical activity and body composition, participated in our study. Lung function was assessed by spirometry and measurements of the combined diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) at rest. Subjects performed a maximal exercise test during which the respiratory parameters were measured.ResultsAt rest, DLCO (30.4 ± 6.1 ml min−1 mmHg−1 vs. 31.4 ± 5.7 ml min−1 mmHg−1, respectively, p = 0.2), its determinants Dm (membrane diffusion capacity) and Vc (pulmonary capillary volume) were comparable among type 1 diabetes and control groups, respectively. Nevertheless, spirometry parameters (forced vital capacity = 4.9 ± 1.0 L vs. 5.5 ± 1.0 L, p < 0.05; forced expiratory volume 1 = 4.0 ± 0.7 L vs. 4.3 ± 0.7 L, p < 0.05) were lower in individuals with type 1 diabetes, although in the predicted normal range. During exercise, ventilatory response to exercise was different between the two groups: tidal volume was lower in type 1 diabetes vs. individuals without diabetes (p < 0.05). Type 1 diabetes showed a reduced VO2max (34.7 ± 6.8 vs. 37.9 ± 6.3, respectively, p = 0.04) in comparison to healthy subjects.ConclusionsIndividuals with uncomplicated type 1 diabetes display normal alveolar‐capillary diffusion capacity and at rest, while their forced vital capacity, tidal volumes and VO2 are reduced during maximal exercise.
Microbial adhesion and viability on novel CAD/CAM framework materials for implant‐supported hybrid prostheses
Authors: Vulović Stefan , Popovac Aleksandra , Radunović Milena , Petrović Sanja , Todorović Miloš , Milić‐Lemić Aleksandra 
Published: December 2022

AbstractThe aim of the study was to investigate the adhesion and viability of Streptococcus oralis and Candida albicans under in vitro conditions on CAD/CAM framework materials for implant‐supported hybrid prostheses. Twenty‐nine specimens were prepared from each of three different materials: ZR (zirconia), PEEK (polyether ether ketone) and CoCr4 (CoCr4 alloy). The experimental part included surface roughness (SR) and contact angle of water (CAW) measurements, followed by colony forming unit (CFU), cell viability assay and scanning electron microscopy (SEM) analyses of Strep. oralis and C. albicans biofilms on the materials’ surfaces. Kruskal‐Wallis and one‐way analysis of variance (ANOVA) tests were used for differences between materials, and the correlation between measurements was estimated using Spearman's correlation coefficient. PEEK specimens revealed higher SR, CAW and CFU mean values, than ZR and CoCr4 specimens. Strong positive correlation was found between SR and CFU and between CAW and CFU for both microbial species. Cell viability assay revealed similar values for both species across materials. Higher numbers of Strep. oralis and C. albicans on PEEK specimens confirm the impact of the higher surface roughness and contact angle values on the microbial adhesion and describes PEEK as less desirable than ZR and CoCr4 from microbiological aspect.