bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between volumes of preterm brain structures, neurodevelopmental outcomes, and neonatal morbidities
Authors: Park Seul Gi , Yang Hyo Ju , Lim Soo Yeon , Kim Seh Hyun , Shin Seung Han , Kim Ee-Kyung , Kim Han-Suk 
Published: March 2023

Abstract
Purpose: Premature infants are prone to impaired neurodevelopmental outcomes due to brain injury or underdevelopment. However, these outcomes may be present without any brain lesions. The association between neonatal morbidities and the volume of segmentalbrain structures is not fully understood. Therefore, we analyzed the association between brain structure volumes, neonatal morbidities, and neurodevelopmental outcomesin extremepreterm infants.
Methods: This retrospective cohort study included 158 extreme preterm infants, in whom brain magnetic resonance imaging at term equivalent age (TEA-MRI) and neurodevelopmental evaluation wereperformed at a corrected age of 18–24 months.Patients with congenital anomalies or significant brain lesions, such as high-grade intraventricular hemorrhage and periventricular leukomalacia were excluded. Medical records, including the Bayley Scales of Infant and Toddler Development 3rd Edition (BSID-III), of preterm infants were reviewed and analyzed. FreeSurfer infant software was used to evaluatebrain structures, while volumes of specific brain regions were adjusted for gestational age and postmenstrual age on MRI using multivariate regression analysis.
Results: Preterm infants with neurodevelopmental impairment had smaller midbrain (aOR 0.804, 95% CI 0.647–0.998). Neonatal morbidities of preterm infants included respiratory distress syndrome (RDS), which was associated with a smaller volume of the medulla (aOR 0.593, 95% CI 0.387–0.908), ventral diencephalon (aOR 0.730, 95% CI 0.572–0.932), and putamen (aOR 0.874, 95% CI 0.788–0.969). Patent ductus arteriosus (PDA) requiring surgery was associated with a smaller volume of the pons (aOR 0.727, 95% CI 0.594–0.889) and vermis (aOR 0.766, 95% CI 0.646–0.907). Retinopathy of prematurity (ROP) requiring surgery was associated with a smaller pons volume (aOR 0.729, 95% CI 0.600–0.886). Necrotizing enterocolitis (NEC) requiring surgery was associated with a smaller volume of the pons (aOR 0.751, 95% CI 0.661–0.854), vermis (aOR 0.832, 95% CI 0.745–0.930), and cerebellum (aOR 0.974, 95% CI 0.960–0.989).
Conclusions: Among preterm infants without significant brain injuries, smaller volume of midbrain was associated with impaired neurodevelopment. RDS and morbidities requiring surgery such as PDA, ROP, and NEC were associated with reduced segmental volumes of the brain in preterm infants.
Loop 3D printing: recyclable photoresins for light-mediated additive manufacturing
Authors: de pariza xabier lopez , varela oihane , Catt Samantha O. , Long Timothy E. , Blasco Eva , Sardon Haritz 
Published: March 2023

Abstract
Additive manufacturing (AM) of polymeric materials has allowed the manufacturing of complex structures for a wide range of applications. Among AM methods vat photopolymerization(VP) techniques are desired owing to their improved efficiency and printing resolution. Nevertheless, the major portion of resins available for VP are based on systems with limited or negligible recyclability. Here, we develop an approach that enables the printing of a resin that could be re-printed with retained properties and appearance. To that end, we take advantage of the potential of polythiourethane chemistry, which not only permits the “click” reaction between polythiols and polyisocyanates in the presence of organic bases, allowing a fast printing process, but also chemical recycling, reshaping and reparation of the printed structures, paving the way toward the development of truly sustainable recyclable photoprintable resins. We demonstrate that this closed-loop 3D printing process is feasible both in the macroscale and microscale via DLP or DLW respectively.
A Heuristic Algorithm for LPN Decoding with Improved Memory and Time Efficiency
Authors: Shiyuan Yin , Min Jin 
Published: March 2023

Abstract
The LPN problem, which forms the basis of many lightweight and post-quantum cryptographic schemes, has recently received considerable attention. The solution to this problem typically involves two distinct phases, namely the reduce phase and the decode phase. While current research primarily focuses on the reduce phase, the most advanced decoding algorithm, FWHT, suffers from high computational costs in terms of time and space complexity. In this article, we propose a novel LPN decoding algorithm, GNS, which utilizes a heuristic approach to achieve significantly reduced memory and time complexity compared to FWHT. Experimental comparisons between the FWHT and GNS algorithms were conducted, with the computational results demonstrating that the proposed GNS algorithm is both efficient and superior to FWHT.
Order-norm continuous operators and Order weakly compact operators
Authors: Zare Sajjad Ghanizadeh , Azar Kazem Haghnejad , Matin Mina , Hazrati Somayeh 
Published: March 2023

Abstract
Let E be a sublattice of a vector lattice F. In this paper, we will introduce and study some properties of this new class of operators as F-order-norm continuousoperators and its relationships with some known classifications of operators. We also define the new class of operators that named order weakly compact operators. A continuous operator T : E → X is said to be F-order weakly compact, if T(A) in X is arelatively weakly compact set for each Fo-bounded A ⊆ E. In this manuscript, we study some properties of this class of operators and its relationships with F-order-norm continuous operators.
Changes to the Activity Index considered depending on hierarchical levels.
Authors: Fuchs Joel Emanuel , Tunger Dirk 
Published: March 2023

Abstract
The Activity Index (AI, Narin et al. (1984)) is a well known and frequently used index in the area of Scientometrics and Bibliometrics. It is used where the activity of entities (e.g., the publication numbers of German universities) can not be compared in absolute numbers because of the different sizes of the observed entities. It negates the sizes of the involved entities and indicates focuses on the examined fields. One important source of bibliometric data is the Web of Science (WoS), a citation data base, that enables – through the work of the Competence Centre of Bibliometrics (CCB) amongst others – the comparison of entities like institutions, sectors, or even countries regarding their publication activity differentiated by research fields. Based on the publication numbers from the WoS the AI presents a method to compare entities on their contribution to certain fields – an indicator of the focus an entity has on this field.
We will introduce the AI and use the AI on the WoS database preprocessed by the CCB. Precisely, we will calculate the ‘classic’ AI of German universities regarding the UNESCO ISCED field classification (UNESCO (2014)). Then, we will introduce the techniques of up-leveling and down-leveling, showing how the AI values of German universities shift depending on the context in which they are observed. Beside our real-world example of shifting AI values of German universities based on the WoS publication numbers preprocessed by the CCB, we will also postulate three hypotheses just to demonstrate, how leveled AI values can be interpreted and used to accept or reject hypotheses.
Finally, we will discuss our results and conclude, that leveling the AI is not just a legerdemain but can be a useful, easy to use tool to enrich interpretations and examinations of AI values.
Probabilistic grammars for modeling dynamical systems from coarse, noisy, and partial data
Authors: Omejc Nina , Gec Boštjan , Brence Jure , Todorovski Ljupčo , Džeroski Sašo 
Published: March 2023

Abstract

Ordinary differential equations (ODEs) are a widely used formalism for the mathematical modeling of dynamical systems, a task omnipresent in scientific domains. The paper introduces a novel method for inferring ODEs from data. It extends ProGED, a method for equation discovery that employs probabilistic context-free grammars for constraining the space of candidate equations. The extended method can discover ODEs from partial observations of dynamical systems, where only a subset of state variables can be observed. To evaluate the performance of the newly proposed method, we perform a systematic empirical comparison with alternative state-of-the-art methods for equation discovery and system identification from complete and partial observations. The comparison involves a set of ten dynamical systems, an extension of the standard Strogatz benchmark. We compare the ability of methods to reconstruct the known ODEs from synthetic data simulated at different temporal resolutions and involving different signal-to-noise levels. The improved ProGED compares favorably to state-of-the-art methods for inferring ODEs from data regarding reconstruction abilities and robustness to data coarseness, noise, and completeness.
Water scarcity and excess: water insecurity in cities of Nepal
Authors: Maskey Gyanu , Pandey Chandra Lal , Giri Monika 
Published: March 2023

AbstractThe world is facing the greatest and most complex twin challenges of water insecurity: scarcity and excess, with their adverse consequences on health, well-being, and developmental outcomes. Against this backdrop, we analyzed the challenges households face due to ‘too much and too little water’. The research employed a qualitative methodology in which data were collected through 40 key informant interviews, informal conversations, and observations during 2020–2021 including a relevant literature review. We note that both ‘too much and too little water’ pose risks to water insecurity. Also, water security cannot be ensured by only dealing with water inadequacy without building a resilient water system and robust institutions. We found that water scarcity has affected other components of water security such as equity, quality, and affordability. Excess water has impacted water infrastructures, degrading the water quality, and risking human health and well-being. The responses to the water challenges were hindered by several constraints such as the limited capacity of the water institutions, frequent leadership changes, political influence, and emerging challenges in the federal context. We suggest timely planning and adopting site-specific innovations to address water scarcity and excess challenges, which include strengthening water services, infrastructures, institutions, and governance.
Asociación entre la infección por virus del papiloma humano y el carcinoma de laringe en adultos de 35-75 años de edad en el Instituto Nacional del Cáncer Rosa Emilia Sánchez Pérez de Tavarez (INCART), en el período agosto 2012 - enero 2019, Santo Domingo, República Dominicana
Authors: Freites González Nathalie Geraldine 
Published: March 2023

Introducción: el carcinoma de cabeza y cuello comprende un grupo de neoplasias que comparten un origen anatómico similar. Ocupan el sexto lugar mundial entre las neoplasias de todas las localizaciones, y el sitio afectado con mayor frecuencia es la cavidad oral. Ahora se reconoce el rol del virus del papiloma humano como factor independiente en el desarrollo de estas neoplasias. En los últimos 15 años se ha observado un incremento en la incidencia de carcinoma de células escamosas inducido por virus del papiloma humano (VPH).
Materiales y métodos: este es un estudio observacional de tipo descriptivo transversal. Se realizó un análisis documental de los expedientes clínicos de los pacientes que cumplan con los criterios de inclusión.
Resultados: en este estudio fue encontrada una prevalencia del 14 % del VPH en cánceres laríngeos. El tipo 16 del VPH fue el único identificado y descrito entre los expedientes clínicos de este estudio y, este último, con una prevalencia de un 20 %.
Discusión: el VPH puede estar involucrado en el desarrollo de algunos cánceres de laringe y su rol puede ser más predominante en hombres mayores de 50 años.
Polimorfismos genéticos implicados en el desarrollo de la púrpura trombocitopénica inmune
Authors: Vásquez Estrada Valeria , Duque Echeverri Laura , Martínez Sánchez Lina María 
Published: March 2023

Introducción: los cambios en el ácido desoxirribonucleico se conocen como mutaciones, estas dan lugar a los polimorfismos, los cuales generan variación alélica entre individuos y diversidad de la misma especie. Se ha sugerido que los polimorfismos genéticos en los mediadores inmunitarios desempeñan un papel fundamental en la patogénesis de muchos trastornos autoinmunes, como en la púrpura trombocitopénica inmune, siendo esta el tipo más común de púrpura trombocitopénica y, a menudo, se diagnostica como un tipo de trastorno autoinmune, debido a la destrucción de las plaquetas mediadas por el sistema inmunitario.
Objetivo: realizar una revisión bibliográfica sobre el papel de los polimorfismos genéticos y su influencia en el desarrollo de la púrpura trombocitopénica inmune.
Métodos: se realizó revisión literaria en inglés y español en PubMed y Elsevier, desde marzo hasta mayo del 2021, con el uso de combinación de palabras clave y términos MeSH, como púrpura trombocitopénica y polimorfismos genéticos. Se realizó análisis y resumen de la literatura encontrada.
Conclusión: la púrpura trombocitopénica inmune es considerada como una patología multifactorial, causada por factores ambientales y genéticos, dentro de los cuales se encuentran los polimorfismos para los mediadores inmunitarios que pueden llevar a una exacerbación de la enfermedad o no intervenir en la misma.
Cardiovascular risk in Hashimoto thyroiditis patients according to their thyroid state: a cross-sectional study
Authors: Gómez Karina , Céspedes Yasmin , Rodríguez Emily 
Published: March 2023

Aims: To investigate the association between cardiovascular risk factors and cardiovascular risk score with the thyroid status of patients with Hashimoto’s Thyroiditis.
Methods: Thirty-eight consenting adults with Hashimoto’s Thyroiditis participated in this cross-sectional study. The cardiovascular risk factors considered included age, sex, blood pressure, body mass index, fast blood glucose, lipid profile, cardiovascular comorbidities, C reactive protein, and erythrocyte sedimentation rate. The Framingham CV risk score was performed. The sample was classified into euthyroid (n = 15), clinical hypothyroidism (n = 9), and subclinical hypothyroidism (n = 13), and included the presence of antithyroid antibodies. Fisher’s exact test was used to determine the association between the variables studied.
Results: 100% of the sample were women; a mean age between 39-59 years old. The category with low risk was the largest (n = 30), equivalent to 78.9%; moderate risk, no patient was obtained; high risk (n = 8) constituted 21.1%. Statistical significance between age and CV risk score in patients with clinical hypothyroidism was found (p < 1), 95% CI. The glucose level in the subclinical hypothyroidism and clinical hypothyroidism had statistical significance. The presence of anti-Thyroglobulin (antiTg) was shown to be closely related to the level of CV risk in patients with subclinical hypothyroidism.
Conclusion: Age, glycemia, anti-Tg, history of DM, dyslipidemia, or cerebrovascular accidents have been linked to raising the risk of developing CVD in up to 10 years depending on their thyroid profile. No evidence of a direct relationship between CV risk score and thyroid state was found in the participants of this study.
Educação inclusiva e tecnologias educacionais: mediação e promoção da aprendizagem no ensino remoto
Authors: Silva Fabíola Cadete , Azevedo Adelis Carvalho Costa , Pereira Petronilha Morais Moreira , Serra Ilka Márcia Ribeiro de Souza 
Published: March 2023

A realidade, atualmente vivenciada na educação, tem possibilitado inúmeras reflexões sobre o fazer pedagógico, intermediado pelas várias redes e vias de acesso à comunicação e informação. Acreditando nessa premissa, esse trabalho tem como principal objetivo refletir sobre as possibilidades de ressignificação do ensino de qualidade, mesmo no contexto das aulas remotas. Apresenta-se, portanto, a proposta do trabalho colaborativo e do uso das tecnologias educacionais, enquanto caminho profícuo na garantia da inclusão e desenvolvimento de aprendizagens significativas. As discussões aqui presentes levam em conta as exigências de uma nova postura docente que contemple a interação, a aprendizagem e o desenvolvimento de competências em uma sociedade do conhecimento e informação, acometida pela pandemia do Coronavírus. As ideias apresentadas no escopo desse trabalho resultam de uma pesquisa bibliográfica de caráter qualitativo, referenciada pelos pensamentos de Mendes (2017), Masetto (2000), Rodrigues (2012), Galvão Filho (2009) e Silva (2001). Mediante este estudo foi possível conceber a relevância de um ensino colaborativo, pautado na reconfiguração dos papeis daqueles que atuam diretamente na orientação dos discentes, permitindo, ainda, situar o papel das tecnologias como grandes aliadas na proposta de uma educação inclusiva. Por sua vez, essas tecnologias precisam ser sustentadas por mediações pedagógicas que diversifiquem o ensino e ampliem habilidades interativas, a fim de colocar o aprendiz na posição de sujeito ativo em seu processo de conhecimento.
Glucose-Activated Switch Regulating Insulin Analog Secretion Enables Long-term Precise Glucose Control in Mice With Type 1 Diabetes
Authors: Xie Lifang , Lu Wanling , Zhang Yanhan , Deng Lu , Liu Ming , Gao Hong , Xie Chunguang , Wang Gang 
Published: March 2023

Genetic modification of non–β-cells to produce insulin is a promising therapeutic strategy for type 1 diabetes; however, it is associated with issues, including biosafety and precise regulation of insulin supply. In this study, a glucose-activated single-strand insulin analog (SIA) switch (GAIS) was constructed to achieve repeatable pulse activation of SIA secretion in response to hyperglycemia. In the GAIS system, the conditional aggregation domain–furin cleavage sequence–SIA fusion protein was encoded by the intramuscularly delivered plasmid and temporarily kept in the endoplasmic reticulum (ER) because it binds to the GRP78 protein; then, upon hyperglycemia, the SIA was released and secreted into the blood. In vitro and in vivo experiments systematically demonstrated the effects of the GAIS system, including glucose-activated and repeatable SIA secretion, long-term precise blood glucose control, recovered HbA1c levels, improved glucose tolerance, and ameliorated oxidative stress. Additionally, this system offers sufficient biosafety, as evidenced by the assays of immunological and inflammatory safety, ER stress, and histological evaluation. Compared with the viral delivery/expression system, the ex vivo implantation of engineered cells, and the exogenous inducer system, the GAIS system combines the advantages of biosafety, effectiveness, persistence, precision, and convenience, providing therapeutic potential for the treatment of type 1 diabetes.

Article Highlights
We undertook this study to establish a glucose-responsive single-strand insulin analog (SIA) self-supply system in vivo. We sought to determine whether the endoplasmic reticulum (ER) can serve as a safe and temporary repository to store designed fusion proteins and release SIAs under hyperglycemic conditions for efficient blood glucose regulation. The intramuscularly expressed plasmid-encoded conditional aggregation domain–furin cleavage sequence–SIA fusion protein can be temporarily stored in the ER, and the SIA can be released under the stimulation of hyperglycemia, resulting in efficient and long-term regulation of stable blood glucose in mice with type 1 diabetes (T1D). The glucose-activated SIA switch system provides applicable potential for T1D therapy, integrating regulation and monitoring of blood glucose levels.
The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo
Authors: Davidson Rebecca K. , Kanojia Sukrati , Wu Wenting , Kono Tatsuyoshi , Xu Jerry , Osmulski Meredith , Bone Robert N. , Casey Nolan , Evans-Molina Carmella , Sims Emily K. , Spaeth Jason M. 
Published: March 2023

The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeling and deacetylase complex as a Pdx1-interacting factor. To identify how loss of Chd4 impacts glucose homeostasis and gene expression programs in β-cells in vivo, we generated an inducible β-cell–specific Chd4 knockout mouse model. Removal of Chd4 from mature islet β-cells rendered mutant animals glucose intolerant, in part due to defects in insulin secretion. We observed an increased ratio of immature-to-mature insulin granules in Chd4-deficient β-cells that correlated with elevated levels of proinsulin both within isolated islets and from plasma following glucose stimulation in vivo. RNA sequencing and assay for transposase-accessible chromatin with sequencing showed that lineage-labeled Chd4-deficient β-cells have alterations in chromatin accessibility and altered expression of genes critical for β-cell function, including MafA, Slc2a2, Chga, and Chgb. Knockdown of CHD4 from a human β-cell line revealed similar defects in insulin secretion and alterations in several β-cell–enriched gene targets. These results illustrate how critical Chd4 activities are in controlling genes essential for maintaining β-cell function.Article HighlightsPdx1–Chd4 interactions were previously shown to be compromised in β-cells from human donors with type 2 diabetes. β-Cell–specific removal of Chd4 impairs insulin secretion and leads to glucose intolerance in mice. Expression of key β-cell functional genes and chromatin accessibility are compromised in Chd4-deficient β-cells. Chromatin remodeling activities enacted by Chd4 are essential for β-cell function under normal physiological conditions.