bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in adult obesity prevalence in Denmark, 1987–2021: age–period–cohort analysis of nationally representative data
Authors: Schramm Stine , Sørensen Thorkild I A , Davidsen Michael , Tolstrup Janne S 
Published: February 2023

Abstract

Background
During the last decades, the prevalence of obesity [body mass index (BMI): weight/height2), ≥30.00 kg/m2] among adults has increased considerably. We examined whether this increase in a high-income, welfare state, like Denmark was driven by age, period or cohort effects, which would inform preventive strategies aiming at reducing the prevalence.

Methods
We used data from the National Representative Health and Morbidity Studies, which are representative surveys of the Danish adult population (age 16 years and above), conducted in 1987, 1994, 2000, 2005, 2010, 2013, 2017 and 2021 (N = 91 684). Participants reported height and weight, from which BMI was calculated after correction for systematic bias in self-reported data and non-response. Age, survey year and birth cohorts were mutually adjusted and adjusted for sex in generalized linear models.

Results
The obesity prevalence increased from 6.1% in 1987 to 18.4% in 2021, similarly in men (18.8%) and women (18.0%) and in all age groups. Age had an inverted u-shaped effect on the prevalence. Compared with individuals aged 16–24 years, the highest rate of obesity was seen for the age group 55–64 years [rate ratio 3.27, 95% confidence interval (CI): 2.58; 4.14]. The increasing rate for each recent survey year over time was compatible with a period effect without any birth cohort effects. The rate for obesity in 2021 was 4.16 in 1987 vs. 1987 (95% CI: 3.10; 5.59).

Conclusions
Obesity prevalence in Denmark increased steadily during the period 1987 through 2021, primarily driven by secular changes over time across all ages and birth cohorts.
Viral infections likely mediate microbial controls on ecosystem responses to global warming
Authors: Wieczynski Daniel J , Yoshimura Kristin M , Denison Elizabeth R , Geisen Stefan , DeBruyn Jennifer M , Shaw A Jonathan , Weston David J , Pelletier Dale A , Wilhelm Steven W , Gibert Jean P 
Published: February 2023

Abstract
Climate change is affecting how energy and matter flow through ecosystems, thereby altering global carbon and nutrient cycles. Microorganisms play a fundamental role in carbon and nutrient cycling and are thus an integral link between ecosystems and climate. Here, we highlight a major black box hindering our ability to anticipate ecosystem climate responses: viral infections within complex microbial food webs. We show how understanding and predicting ecosystem responses to warming could be challenging—if not impossible—without accounting for the direct and indirect effects of viral infections on different microbes (bacteria, archaea, fungi, protists) that together perform diverse ecosystem functions. Importantly, understanding how rising temperatures associated with climate change influence viruses and virus-host dynamics is crucial to this task, yet is severely understudied. In this perspective, we (i) synthesize existing knowledge about virus-microbe-temperature interactions and (ii) identify important gaps to guide future investigations regarding how climate change might alter microbial food web effects on ecosystem functioning. To provide real-world context, we consider how these processes may operate in peatlands—globally significant carbon sinks that are threatened by climate change. We stress that understanding how warming affects biogeochemical cycles in any ecosystem hinges on disentangling complex interactions and temperature responses within microbial food webs.
Manipulation of plant metabolism by pathogen effectors: more than just food
Authors: Cai Jun , Jiang Yuxin , Ritchie Erin S , Macho Alberto P , Yu Feng , Wu Dousheng 
Published: February 2023

Abstract
To successfully infect plants, pathogens secrete effector proteins to the plant apoplast or inside plant cells, where they suppress plant immunity or interfere with other cellular processes to facilitate infection. Plant metabolism is crucial for most cellular processes and plays a key role in defense against pathogens, making it a major target for pathogen effectors. Effector proteins manipulate host metabolism to provide the pathogen with nutrients or to indirectly suppress plant chemical defense responses. Recent studies have shown that pathogens also utilize effectors to shape the microbiota composition by altering the concentration of certain plant metabolites. Here, we summarize current knowledge on the manipulation of plant metabolism by pathogen effectors. We also discuss what remains unknown regarding the manipulation of host metabolism by pathogen effectors.
Identifying vulnerable marine ecosystems: an image-based vulnerability index for the Southern Ocean seafloor
Authors: Gros Charley , Jansen Jan , Untiedt Candice , Pearman Tabitha R R , Downey Rachel , Barnes David K A , Bowden David A , Welsford Dirk C , Hill Nicole A 
Published: February 2023

Abstract
A significant proportion of Southern Ocean seafloor biodiversity is thought to be associated with fragile, slow growing, long-lived, and habitat-forming taxa. Minimizing adverse impact to these so-called vulnerable marine ecosystems (VMEs) is a conservation priority that is often managed by relying on fisheries bycatch data, combined with threshold-based conservation rules in which all “indicator” taxa are considered equal. However, VME indicator taxa have different vulnerabilities to fishing disturbance and more consideration needs to be given to how these taxa may combine to form components of ecosystems with high conservation value. Here, we propose a multi-criteria approach to VME identification that explicitly considers multiple taxa identified from imagery as VME indicator morpho-taxa. Each VME indicator morpho-taxon is weighted differently, based on its vulnerability to fishing. Using the “Antarctic Seafloor Annotated Imagery Database”, where 53 VME indicator morpho-taxa were manually annotated generating &gt;40000 annotations, we computed an index of cumulative abundance and overall richness and assigned it to spatial grid cells. Our analysis quantifies the assemblage-level vulnerability to fishing, and allows assemblages to be characterized, e.g. as highly diverse or highly abundant. The implementation of this quantitative method is intended to enhance VME identification and contextualize the bycatch events.
Transport-driven seasonal abundance of pelagic fishes in the Chukchi Sea observed with seafloor-mounted echosounders
Authors: Levine R M , De Robertis A , Grünbaum D , Wilson C D 
Published: February 2023

AbstractRecent summer surveys of the northeastern Chukchi Sea found pelagic fishes were dominated by large numbers of age-0 Arctic cod (Boreogadus saida, Gadidae) and walleye pollock (Gadus chalcogrammus, Gadidae), while adult fishes were comparatively scarce. The source and fate of these young fishes remain unclear, as sampling in this region is impeded by seasonal ice cover much of the year. Seafloor-mounted echosounders were deployed at three locations in the northeastern Chukchi Sea from 2017 to 2019 to determine the movement and seasonal variability of these age-0 gadids. These observations indicated that the abundance of pelagic fishes and community composition on the Chukchi Sea shelf were highly variable on seasonal time scales, with few fish present in winter. Tracking indicated that fish movements were strongly correlated with local currents. Fishes were primarily displaced to the northeast in summer and fall, with periodic reversals towards the southwest driven by changes in regional wind patterns. The flux of fishes past the moorings indicated that the prevailing northward currents transport a large proportion of the age-0 pelagic fishes present on the Chukchi shelf in summer to the northeast by fall, leading to relatively low abundances of age-1+fishes in this environment.
A systematic review and thematic synthesis exploring the role of pharmacists in supporting better sleep health and managing sleep disorders
Authors: Ashkanani Fatemah Zakareya , Lindsey Laura , Rathbone Adam Pattison 
Published: February 2023

AbstractBackgroundSleep is an essential part of mental and physical well-being. Sleep disorders may lead to psychiatric and physical conditions that contribute to morbidity and mortality. They lead to severe health and economic consequences across high-, intermediate- and low-income countries. Little is known about how pharmacists manage sleep disorders for patients in high, intermediate and low-income countries.MethodFour databases were systematically searched, and titles, abstracts, and full texts were screened to detect relevant studies. Data were extracted from literature and thematically synthesised to identify descriptive and analytical themes.ResultsThirty-four studies met the inclusion criteria. Most studies were from high-income countries (n = 33) and based in community pharmacy settings (n = 17). Four descriptive themes were identified: (1) how pharmacists manage sleep disorders, (2) the impact of pharmacists’ interventions on sleep, (3) barriers to managing sleep by pharmacists and (4) inappropriate sleep disorders management by pharmacists. Three analytical themes were synthesised from extracted data that identified the pharmacists have roles as (1) de-prescribers, (2) collaborators and (3) educators in sleep management services.ConclusionPharmacists have three clear roles in sleep disorder management; deprescribing, collaboration with other healthcare professionals and educators. However, most of the literature is from high-income countries; therefore, further work is needed to explore these roles in low and middle-income countries.
Recent Trends in MALDI-MS Drugs Analysis in Human Hair: Pre-Analytical and Analytical Challenges and Pitfalls
Authors: Kernalléguen Angéline , Kintz Pascal , Leonetti Georges , Lafitte Daniel , Pélissier-Alicot Anne-Laure 
Published: February 2023

Abstract
The value of hair in forensic toxicology has already been widely demonstrated. It offers a much wider detection window than other matrices, and its segmental analysis allows the documentation of a single, occasional or regular consumption of a large number of molecules. To date, considerable efforts are being made to achieve very high sensitivity using increasingly effective techniques in the forensic analysis of hair (gas chromatography with electron ionization mass spectrometry (GC--EI-MS); gas chromatography with chemical ionization mass spectrometry (GC--CI-MS); gas chromatography–tandem mass spectrometry (GC--MS-MS); high or ultra performance liquid chromatography–tandem mass spectrometry (HPLC–MS-MS and UPLC–MS-MS)). Since the early 2000s, work has been carried out to analyze hair using matrix-assisted laser desorption ionization (MALDI) coupled with imaging mass spectrometry (IMS). Intact, cut or pulverized, human head hairs are analyzed in all their forms. With a simplified and rapid sample preparation protocol, MALDI-IMS appears to be an attractive option for the forensic interpretation of hair analysis. The high spatial resolution clearly competes with conventional methods and strand segmentation. This article provides a complete overview on MALDI techniques used and its applications to better understand the pre-analytical and the analytical parts in the hair analysis.
Pandemic Recessions and Contact Tracing
Authors: Melosi Leonardo , Rottner Matthias 
Published: February 2023

Abstract
We study contact tracing in a new macro-epidemiological model with asymptomatic transmission and limited testing capacity. Contact tracing is a testing strategy that aims to reconstruct the infection chain of newly symptomatic agents. This strategy may be unsuccessful because of an externality leading agents to expand their interactions at rates exceeding policymakers’ ability to test all the traced contacts. Complementing contact tracing with timely deployed containment measures (e.g., social distancing or a tighter quarantine policy) corrects this externality and delivers outcomes that are remarkably similar to the benchmark case where tests are unlimited. We provide theoretical underpinnings to the risk of becoming infected in macro-epidemiological models. Our methodology to reconstruct infection chains is not affected by curse-of-dimensionality problems.
Treatment outcome after sequential chemotherapy with cisplatin-etoposide, amrubicin and nogitecan in patients with treatment-related pure small-cell neuroendocrine prostate cancer
Authors: Ueki Hideto , Terakawa Tomoaki , Hara Takuto , Hirata Junichiro , Jimbo Naoe , Okamura Yasuyoshi , Bando Yukari , Furukawa Junya , Harada Kenichi , Nakano Yuzo , Fujisawa Masato 
Published: February 2023

Abstract

Objective
This study retrospectively reviewed the clinical characteristics and treatment outcomes of patients with histologically diagnosed treatment-related pure small-cell neuroendocrine prostate cancer.

Methods
We retrospectively evaluated data for 13 patients with treatment-related neuroendocrine prostate cancer who were diagnosed between May 2015 and February 2022. Standardized systemic therapies of etoposide plus cisplatin (or carboplatin), amrubicin and nogitecan were selected as sequential treatments. Cancer-specific survival and progression-free survival were evaluated as the primary endpoint. The Cox proportional hazards model was used to evaluate the relationships between treatment regimens, clinical variables, cancer-specific survival and progression-free survival.

Results
The median cancer-specific survival after diagnosis for all patients was 22.4 months (range 1.3–33.4 months). The median progression-free survival was 9.3 months after first-line etoposide plus cisplatin (or carboplatin) treatment (n = 13); 4.2 months after second-line amrubicin treatment (n = 4); and &gt;15 months after third-line nogitecan treatment (n = 2). The median progression-free survival after first-line chemotherapy of the liver metastasis (−) group was 10.2 months, and that of the (+) group was 5.3 months (P = 0.015, hazard ratio = 11.6, 95% confidence interval = 1.01 – 133.7). No clinicopathological parameters were identified as significant independent predictors of cancer-specific survival in univariate analysis.

Conclusion
Sequential chemotherapy with etoposide plus cisplatin (or carboplatin), amrubicin and nogitecan may be helpful for patients with treatment-related pure small-cell neuroendocrine prostate cancer. Early biopsy of metastases and initiation of effective therapy is essential for patients with progressive castration-resistant prostate cancer and low prostate-specific antigen.
“As Inscrutable as the Sphinx, but Far More Dangerous”: Trends in Democratic–Personalist Conflict
Authors: Schramm Madison 
Published: February 2023

AbstractWhile liberal democracies do not go to war with other democracies, they frequently engage in conflict with autocratic regimes. Little research has been conducted, however, to indicate what type of autocracies liberal democracies tend to target. This article demonstrates that liberal democracies are more likely to initiate conflict against personalist regimes, rather than autocracies with some form of collective leadership. I argue that, when a conflict of interest arises between a liberal democracy and a personalist regime, liberal foreign policy elites’ psychology and social identity work together to produce particular emotional responses, predisposing them to favor coercive action against personalist regimes. This paper presents new quantitative evidence regarding patterns in democratic–personalist conflict and introduces process evidence from US foreign policy decision-making during the Gulf Crisis.
Prediction of potential suitable areas forBroussonetia papyriferain China using the MaxEnt model and CIMP6 data
Authors: Wang Meiquan , Guan Qingwei 
Published: February 2023

AbstractBroussonetia papyrifera is an important native tree species in China with strong adaptability, wide distribution and economic importance. Climate change is considered as the main threat to ecological processes and global biodiversity. Predicting the potential geographical distribution of B. papyrifera in future climate change scenarios will provide a scientific basis for ecological restoration in China. Principal component analysis and Pearson correlation analysis were conducted to select the environmental variables. The distribution and changes in the potential suitable area for B. papyrifera were predicted using the maximum entropy model and the CIMP6 dataset from 2041 to 2060. The current highly suitable areas for B. papyrifera were mainly located in Guangdong (5.60 × 104 km2), Guangxi (4.39 × 104 km2), Taiwan (2.54 × 104 km2) and Hainan (2.17 × 104 km2). The mean temperature of the coldest quarter (11.54–27.11 °C), precipitation of the driest quarter (51.48–818.40 mm) and precipitation of the wettest quarter (665.51–2302.60 mm) were the main factors limiting the suitable areas for B. papyrifera. The multi-modal average of the highly and the total suitable areas for B. papyrifera were 111.42 × 104 and 349.11 × 104 km2 in the SSP5-8.5 scenario, while those in the SSP1-2.6 scenario were 87.50 × 104 and 328.29 × 104 km2, respectively. The gained suitable areas for B. papyrifera will expand to the western and northern China in the future scenarios. The multi-model averaging results showed that the potential available planting area was 212.66 × 104 and 229.32 × 104 km2 in the SSP1-2.6 and SSP5-8.5 scenarios, respectively, when the suitable area within the farmland range was excluded.
The Two Gentlemen of Zurich: Marcus Stapfer and Johann Rudolph Hess, Swiss Travellers to England (1611–13), and Their Shakespeare Quartos
Authors: Erne Lukas 
Published: February 2023

Abstract
This article recovers parts of the biographically and bibliographically intertwined history of two early modern Zurich citizens, their joint travels and the Shakespeare quartos each of them owned. The first part focuses on a previously forgotten copy of the third quarto edition of Pericles (1611), now at the Zurich Central Library, and its original owner recorded on the title page, Marcus Stapfer (1591–1619). The second part of the article adds to the investigation Johann Rudolf Hess (1588–1655), the owner of the other early Shakespeare quartos at the Zurich Central Library. Stapfer and Hess jointly undertook extended educational travels from 1610 to 1614, including to London, where they are likely to have acquired their Shakespeare quartos in the summer of 1613. The article traces what is known about the quartos’ subsequent ownership history, before concluding that Shakespeare thus appears to have had a continuous bibliographic presence in Switzerland since the early seventeenth century.
A reunion of Gödel, Tarski, Carnap and Rosser
Authors: Salehi Saeed 
Published: February 2023

Abstract
We unify Gödel’s first incompleteness theorem (1931), Tarski’s undefinability theorem (1933), Gödel-Carnap’s diagonal lemma (1934) and Rosser’s (strengthening of Gödel’s first) incompleteness theorem (1936), whose proofs resemble much and use almost the same technique.
Information economics in the criminal standard of proof
Authors: Dahlman Christian , Nordgaard Anders 
Published: February 2023

AbstractIn this paper we model the criminal standard of proof as a twofold standard requiring sufficient probability of the factum probandum and sufficient informativeness. The focus of the paper is on the latter requirement, and we use decision theory to develop a model for sufficient informativeness. We demonstrate that sufficient informativeness is fundamentally a question of information economics and switch-ability. In our model, sufficient informativeness is a cost-benefit-analysis of further investigations that involves a prediction of the possibility that such investigations will produce evidence that switches the decision from conviction to acquittal. Critics of the Bayesian approach to legal evidence have claimed that ‘weight’ cannot be captured in a Bayesian model. Contrary to this claim, our model shows how sufficient informativeness can be modelled as a second order probability.
Impact of Gestational Diabetes on the Thymus Gland of Rat’s Offspring and the Possible Ameliorating Effect of Thymoquinone: Biochemical, Histological, and Immunohistochemical Study
Authors: Mokhtar Yasmine Osama Mohamed , Mokhemer Sahar Ahmed , Mohammed Hanaa Hassanein , El-Tahawy Nashwa Fathy Gamal 
Published: February 2023

AbstractGestational diabetes mellitus (GDM) not only has short-term side effects on offspring but also has an increased risk of developing chronic diseases in adulthood. The thymus gland is a vital organ of immune system and thymoquinone (TQ) has an immunomodulatory effect. This study aimed to investigate the long-term adverse effects of GDM on offspring’s thymus gland and the ameliorating effect of TQ. Pregnant rats were divided into four groups: C-group, T-group, GD-group, and GD + T-group. Offspring of all groups were subdivided into two subgroups, one sacrificed on day 21 and the other on day 42. The thymus of the offspring in the GD-group at both time points revealed a significant decrease in thymic weight, superoxide dismutase (SOD), and reduced glutathione (GSH) levels with a significant increase in malondialdehyde (MDA), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) levels. Moreover, there were microscopic degenerative changes, a significant decrease in C/M ratio, CD3, CD4, and CD8 immune expression, and a significant increase in activated caspase-3 immune expression. Interestingly, TQ administration revealed a significant increase in thymic weight, thymic SOD and GSH, C/M ratio, and CD3, CD4, and CD8 immune expression with a significant decrease in MDA, IL-8, TNF-α and activated caspase-3. For the first time, this study has shown that GDM causes long-term oxidative stress, apoptosis, and inflammation in offspring’s thymus and these changes could be attenuated by TQ.
Martian dayside magnetic topology and structures of the cross-terminator magnetic loops – multispecies magnetohydrodynamic simulations
Authors: Li Guokan , Lu Haoyu , Li Yun , Cao Jinbin , Li Shibang 
Published: February 2023

ABSTRACTThe interaction between impinging magnetized solar wind and Martian crustal fields produces complexly distributed magnetic topologies in the dayside magnetosphere. This study focused on obtaining the distribution of Martian dayside magnetic topology and the structures of the cross-terminator magnetic loops. A 3D multispecies magnetohydrodynamic model was employed to simulate the interactions between Mars and solar winds, and a 110° spherical harmonic model was used to calculate the crustal fields. We randomly extracted more than 1000 magnetic field lines from the near-Mars region of the model results. These results indicate the existence of large-scale closed fields and high-inclination-angle open fields in the Southern hemisphere, exerting their influence even above the height of the ionopause, resulting in a complex relationship between plasma motion and magnetic topology distribution. In contrast, the plasma motion patterns in the Northern hemisphere are similar to those observed in unmagnetized planets. Furthermore, the model results show two types of cross-terminator magnetic loop. Small-scale cross-terminator magnetic loops connect the local atmosphere on the dayside and nightside, whereas many large-scale magnetic loops cross the centre–tail region and extend more than 2RM downstream of Mars, especially in the Southern hemisphere. Finally, the clock angle distribution shows magnetic field distortion at 1000 km altitude. This study provides a clearer and more detailed description of the Martian dayside magnetic topology and the structures of the cross-terminator magnetic loops.