bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of atrioventricular septal defects with and without down syndrome: analysis of the national inpatient database
Authors: Aly Safwat , Qattea Ibrahim , Othman Hasan , Nguyen Hoang H. , Aly Hany Z. 
Published: September 2023

AbstractBackground:Controversial data exist about the impact of Down syndrome on outcomes after surgical repair of atrioventricular septal defect.Aims:(A) assess trends and outcomes of atrioventricular septal defect with and without Down syndrome and (B) determine risk factors associated with adverse outcomes after atrioventricular septal defect repair.Methods:We queried The National Inpatient Sample using International Classification of Disease codes for patients with atrioventricular septal defect < 1 year of age from 2000 to 2018. Patients’ characteristics, co-morbidities, mortality, and healthcare utilisation were evaluated by comparing those with versus without Down syndrome.Results:In total, 2,318,706 patients with CHD were examined; of them, 61,101 (2.6%) had atrioventricular septal defect. The incidence of hospitalisation in infants with atrioventricular septal defect ranged from 4.5 to 7.5% of all infants hospitalised with CHD per year. A total of 33,453 (54.7%) patients were associated with Down syndrome. Double outlet right ventricle, coarctation of the aorta, and tetralogy of Fallot were the most commonly associated with CHD in 6.9, 5.7, and 4.3% of patients, respectively. Overall atrioventricular septal defect mortality was 6.3%. Multivariate analysis revealed that prematurity, low birth weight, pulmonary hypertension, and heart block were associated with mortality. Down syndrome was associated with a higher incidence of pulmonary hypertension (4.3 versus 2.8%, p < 0.001), less arrhythmia (6.6 versus 11.2%, p < 0.001), shorter duration for mechanical ventilation, shorter hospital stay, and less perioperative mortality (2.4 versus 11.1%, p < 0.001).Conclusion:Trends in atrioventricular septal defect hospitalisation had been stable over time. Perioperative mortality in atrioventricular septal defect was associated with prematurity, low birth weight, pulmonary hypertension, heart block, acute kidney injury, and septicaemia. Down syndrome was present in more than half of atrioventricular septal defect patients and was associated with a higher incidence of pulmonary hypertension but less arrhythmia, lower mortality, shorter hospital stay, and less resource utilisation.
North–South Trade-Related Technology Diffusion and the East Asia–Latin America Productivity Gap
Authors: Schiff Maurice , Wang Yanling 
Published: September 2023

AbstractThis paper examines the impact of trade-related technology diffusion from G7 countries to Latin America and East Asia on total factor productivity controlling for education, governance, and distance. We build on the trade and distance-focused strands of the technology diffusion literature and find that (i) total factor productivity (TFP) increases with education, trade, and governance (ETG) and declines with distance to the G7 countries; (ii) increasing Latin America's ETG to East Asia's level would double TFP, accounting for about 75% of the TFP gap between the two country groups; and (iii) South America's greater remoteness relative to Mexico's from the US and Canada significantly reduces its TFP and similarly for Singapore's greater remoteness from Japan relative to Hong Kong.
Lowering Regulatory Trade Costs
Authors: Pelkmans Jacques 
Published: September 2023

AbstractNegotiations on ‘deeper’ trade agreements and estimates of tariff equivalents have increased the awareness that regulatory trade costs are (too) high. This paper discusses ways to effectively lower such costs, reviewing the potential role of trade agreements and international regulatory cooperation, and the approaches that have been taken in different world regions. Attention is also paid to cost reduction via global technical standardization. Key issues are how to reduce the prevalence of national standards setting and how to best promote international standards. In both dimensions, Europe is argued to play a frontrunner role.
Globotics and Development: When Manufacturing Is Jobless and Services Are Tradeable
Authors: Baldwin Richard , Forslid Rikard 
Published: September 2023

AbstractGlobalization and robotics (globotics) are jointly transforming the world economy at an explosive pace. While much of the literature has focused on rich nations, the changes are quite likely to affect developing nations in important ways. The premise of the paper – which should be regarded as a thought-piece – is based on an extreme thought experiment. What does development look like when digital technology has rendered manufacturing jobless and many services freely traded? Our conclusion is that the service-led development path may become the norm rather than the exception; think India, not China. Since success in the service sector is based on quite different factors than success in manufacturing, development strategies and mindsets may have to change. This is an optimistic conclusion since it suggests that developing nations can directly export the source of their comparative advantage – low-cost labour – without having first to make goods with that labour.
Evaluating the Compatibility of Hematite (U‐Th)/He Data and Hematite‐Carried Secondary Magnetizations: An Example From the Colorado Front Range
Authors: Jensen Jordan L. , Ault Alexis K. , Geissman John W. 
Published: September 2023

AbstractAncient magnetization(s), often recorded by hematite (Fe2O3), provide key paleomagnetic constraints on plate interactions through time. Primary remanent magnetizations may be modified or overprinted by secondary processes that complicate interpretations of paleomagnetic data. Hematite (U‐Th)/He (hematite He) dating has the potential to resolve when secondary magnetizations were acquired. Here, we compare hematite He data and paleomagnetic results in Paleoproterozoic crystalline rocks, meters below a major nonconformity in the Colorado Front Range, USA. Prior work and new rock magnetic data indicate that pervasive hematite alteration records a secondary chemical remanent magnetization (CRM) during the Permo‐Carboniferous Reverse Superchron, coincident with the Ancestral Rocky Mountain orogeny. We target minor hematite‐coated faults cutting basement for (U‐Th)/He analyses because they are of sufficient hematite purity to yield geologically meaningful dates. Two samples yield overlapping and scattered individual hematite He dates ranging from ∼138 to 27 Ma (n = 33), significantly younger than the age of the late Paleozoic CRM. Scanning electron microscopy, electron probe microanalysis, and Raman spectroscopy indicate that aliquots have variable grain size distributions and fluorocarbonate impurities. Thermal history models support hematite on fault surfaces mineralized coeval with CRM acquisition during the late Paleozoic, and hematite He data scatter reflects variable He loss during Mesozoic burial owing to differences in grain size distribution from fault slip comminution and in chemistry among aliquots. Our results underscore the differences in temperature sensitivity and sampling requirements between paleomagnetic and hematite He investigations and illustrate that hematite He dates will usually be younger than preserved remanent magnetizations.
Geodynamic Evolution of the East African Superplume: Insights From Volcanism in the Western Turkana Basin
Authors: Cai Yue , Mana Sara , Cox Stephen E. , Beck Catherine C. , Feibel Craig , Hanley Jean , Liu Tanzhuo , Bolge Louise , Hemming Sidney , Goldstein Steven L. 
Published: September 2023

AbstractThere is a consensus that volcanism along the East African Rift System (EARS) is related to plume activities. However, because of our limited knowledge of the local lithospheric mantle, the dynamics of the plume are poorly constrained by magma chemistry. The Turkana Basin is one of the best places to study plume‐related volcanism because the lithospheric mantle there is unusually thin. New Ar‐Ar geochronology and geochemical data on lavas from western Turkana show that Eocene volcanics have relatively low 206Pb/204Pb (<19.1) and high εNd (>3.78). Their relatively high Ba/Rb (35–78) ratios suggest contributions from the shallow lithospheric mantle. Oligo‐Miocene Turkana volcanics have HIMU‐ and EMI‐ type enriched mantle signatures with overall lower Ba/Rb ratios, which is consistent with partial melting of plume material. Pliocene and younger Turkana volcanics have low Ba/Rb and Sr‐Nd‐Pb isotope ratios that resemble those of Ethiopian volcanics with elevated 3He/4He ratios. This temporal variation can be reconciled with a layered plume model where an outer layer of ancient recycled oceanic crust and sediment overlies more primitive lower mantle material. Beneath Ethiopia, the outer layer of the plume is either missing or punctured by the delamination of the thicker overlying lithospheric mantle at ca. 30 Ma, an event that would have facilitated the rapid upwelling of the inner portion of the plume and triggered the Ethiopian flood volcanism. The outer layer of the plume may be thicker in the southern EARS, which could explain the occurrence of young HIMU‐ and EMI‐type volcanics with primordial noble gas signatures.
Reducing the Cold Bias of the WRF Model Over the Tibetan Plateau by Implementing a Snow Coverage‐Topography Relationship and a Fresh Snow Albedo Scheme
Authors: Zhou Xu , Ding Baohong , Yang Kun , Pan Jinmei , Ma Xiaogang , Zhao Long , Li Xin , Shi Jiancheng 
Published: September 2023

AbstractMost climate models show systematic cold biases during snow‐covered period over the Tibetan Plateau (TP), which is associated with snow and surface albedo overestimations. In this work, a snow cover fraction (SCF) scheme and a recently developed albedo scheme for shallow snow are implemented in the Noah‐MP land surface model coupled with the Weather Research and Forecasting (WRF) model. The SCF scheme introduces subgrid orographic variability to reduce the SCF, and the shallow‐snow albedo scheme parameterizes the fresh‐snow albedo as a function of the snow depth (SD). Evaluations by remote sensing data show that both schemes can effectively alleviate the overestimation of the simulated surface albedo, SCF, snow water equivalent, and SD over the TP. The reductions in the modeled SCF and snow albedo directly lead to lower surface albedo values and thus more surface solar radiation absorption, which accelerates snow melting and causes surface warming effects. Further comparisons with Moderate Resolution Imaging Spectroradiometer data and station observations show that both schemes can significantly reduce the cold biases in the surface skin temperature (from −4.39°C to 0.19°C for the TP mean) and 2‐m air temperature (from −4.48°C to −1.05°C for the station mean) during the cold season (October to May of next year) in the study region. This work provides guidance for advancing the snow‐related physics in climate models and the improved WRF model could facilitate weather forecasting and climate prediction for the plateau region.
Displacement Patterns of a Newtonian Fluid by a Shear‐Thinning Fluid in a Rough Fracture
Authors: Zhang Le , Yang Zhibing , Méheust Yves , Neuweiler Insa , Hu Ran , Chen Yi‐Feng 
Published: September 2023

AbstractTwo‐phase flow involving non‐Newtonian fluids in fractured media is of vital importance in many natural processes and subsurface engineering applications, such as rock grouting, groundwater remediation, and enhanced oil recovery. Yet, how the displacement dynamics is impacted by the non‐Newtonian rheology remains an open question. Here, we conduct primary drainage experiments in which a shear‐thinning Xanthan gum solution displaces a silicone oil in a transparent rough fracture for a wide range of shear‐thinning property (controlled by polymer concentration) and flow rates. We first evaluate the effects of shear‐thinning property on displacement efficiency. Based on qualitative and quantitative analyses of the observed fluid morphologies, we present an experimental phase diagram of the obtained displacement patterns. We characterize a novel displacement pattern where the fluid‐fluid interface changes from stable (plug flow) to unstable (fingering) as the fracture aperture, averaged over the transverse direction, varies along the mean flow direction. We demonstrate that the existence of this mixed displacement pattern can be explained by local viscosity heterogeneity induced by the coupling of the shear‐thinning behavior and the spatial variability of apertures. Finally, we propose a theoretical model elucidating the mechanisms behind the flow regime transitions. The interface stability criterion predicted by this model exhibits good agreement with the experimental measurements, and stresses the potentially important role of fluid rheology, coupled to aperture variability, in immiscible displacements in rough fractures. These findings provide new insights into the dynamics of immiscible two‐phase flows with non‐Newtonian effects, and has potential implications for the aforementioned engineering applications.
The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications
Authors: Samuels Mark , Jones William , Towler Benjamin , Turner Charlotte , Robinson Stephen , Giamas Georgios 
Published: September 2023

AbstractBreast Cancer (BC) is the most common form of cancer worldwide, responsible for 25% of cancers in women. Whilst treatment is effective and often curative in early BC, metastatic disease is incurable, highlighting the need for early detection. Currently, early detection relies on invasive procedures, however recent studies have shown extracellular vesicles (EVs) obtained from liquid biopsies may have clinical utility. EVs transport diverse bioactive cargos throughout the body, play major roles in intercellular communication and, importantly, mirror their cell of origin. In cancer cells, EVs alter the behaviour of the tumour microenvironment (TME), forming a bridge of communication between cancerous and non-cancerous cells to alter all aspects of cancer progression, including the formation of a pre-metastatic niche. Through gene regulatory frameworks, non-coding RNAs (ncRNAs) modulate vital molecular and cellular processes and can act as both tumour suppressors and oncogenic drivers in various cancer types. EVs transport and protect ncRNAs, facilitating their use clinically as liquid biopsies for early BC detection. This review summarises current research surrounding ncRNAs and EVs within BC, focusing on their roles in cancer progression through bi-directional communication with the microenvironment and their diagnostic implications.
AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway
Authors: Deng Liming , Bao Wenming , Zhang Baofu , Zhang Sina , Chen Ziyan , Zhu Xuewen , He Bangjie , Wu Lijun , Chen Xiaohu , Deng Tuo , Chen Bo , Yu Zhengping , Wang Yi , Chen Gang 
Published: September 2023

AbstractIntrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effect of lenvatinib on ICC is unknown. In this study, we found that AZGP1 was the key target of lenvatinib in ICC, and its low expression in ICC cancer tissues was associated with a poor prognosis in patients. Lenvatinib is a novel AZGP1 agonist candidate for ICC that inhibits ICC-EMT by regulating the TGF-β1/Smad3 signaling pathway in an AZGP1-dependent manner. Furthermore, we found that lenvatinib could increase AZGP1 expression by increasing the acetylation level of H3K27Ac in the promoter region of the AZGP1 gene, thereby inhibiting EMT in ICC cells. In conclusion, lenvatinib activates AZGP1 by increasing the acetylation level of H3K27Ac on the AZGP1 promoter region and regulates the TGF-β1/Smad3 signaling pathway in an AZGP1-dependent manner to inhibit ICC-EMT. This study offers new insight into the mechanism of lenvatinib in the treatment of ICC and provides a theoretical basis for new treatment methods.
Search for 22Na in novae supported by a novel method for measuring femtosecond nuclear lifetimes
Authors: Fougères Chloé , de Oliveira Santos François , José Jordi , Michelagnoli Caterina , Clément Emmanuel , Kim Yung Hee , Lemasson Antoine , Guimarães Valdir , Barrientos Diego , Bemmerer Daniel , Benzoni Giovanna , Boston Andrew J. , Böttger Roman , Boulay Florent , Bracco Angela , Čeliković Igor , Cederwall Bo , Ciemala Michał , Delafosse Clément , Domingo-Pardo César , Dudouet Jérémie , Eberth Jürgen , Fülöp Zsolt , González Vicente , Gottardo Andrea , Goupil Johan , Hess Herbert , Jungclaus Andrea , Kaşkaş Ayşe , Korichi Amel , Lenzi Silvia M. , Leoni Silvia , Li Hongjie , Ljungvall Joa , Lopez-Martens Araceli , Menegazzo Roberto , Mengoni Daniele , Million Benedicte , Mrázek Jaromír , Napoli Daniel R. , Navin Alahari , Nyberg Johan , Podolyák Zsolt , Pullia Alberto , Quintana Begoña , Ralet Damien , Redon Nadine , Reiter Peter , Rezynkina Kseniia , Saillant Frédéric , Salsac Marie-Delphine , Sánchez-Benítez Angel M. , Sanchis Enrique , Şenyiğit Menekşe , Siciliano Marco , Smirnova Nadezda A. , Sohler Dorottya , Stanoiu Mihai , Theisen Christophe , Valiente-Dobón Jose J. , Ujić Predrag , Zielińska Magdalena 
Published: September 2023

AbstractClassical novae are thermonuclear explosions in stellar binary systems, and important sources of 26Al and 22Na. While γ rays from the decay of the former radioisotope have been observed throughout the Galaxy, 22Na remains untraceable. Its half-life (2.6 yr) would allow the observation of its 1.275 MeV γ-ray line from a cosmic source. However, the prediction of such an observation requires good knowledge of its nucleosynthesis. The 22Na(p, γ)23Mg reaction remains the only source of large uncertainty about the amount of 22Na ejected. Its rate is dominated by a single resonance on the short-lived state at 7785.0(7) keV in 23Mg. Here, we propose a combined analysis of particle-particle correlations and velocity-difference profiles to measure femtosecond nuclear lifetimes. The application of this method to the study of the 23Mg states, places strong limits on the amount of 22Na produced in novae and constrains its detectability with future space-borne observatories.
Synthesis and characterization of a formal 21-electron cobaltocene derivative
Authors: Takebayashi Satoshi , Ariai Jama , Gellrich Urs , Kartashov Sergey V. , Fayzullin Robert R. , Kang Hyung-Been , Yamane Takeshi , Sugisaki Kenji , Sato Kazunobu 
Published: September 2023

AbstractMetallocenes are highly versatile organometallic compounds. The versatility of the metallocenes stems from their ability to stabilize a wide range of formal electron counts. To date, d-block metallocenes with an electron count of up to 20 have been synthesized and utilized in catalysis, sensing, and other fields. However, d-block metallocenes with more than formal 20-electron counts have remained elusive. The synthesis and isolation of such complexes are challenging because the metal–carbon bonds in d-block metallocenes become weaker with increasing deviation from the stable 18-electron configuration. Here, we report the synthesis, isolation, and characterization of a 21-electron cobaltocene derivative. This discovery is based on the ligand design that allows the coordination of an electron pair donor to a 19-electron cobaltocene derivative while maintaining the cobalt–carbon bonds, a previously unexplored synthetic approach. Furthermore, we elucidate the origin of the stability, redox chemistry, and spin state of the 21-electron complex. This study reveals a synthetic method, structure, chemical bonding, and properties of the 21-electron metallocene derivative that expands our conceptual understanding of d-block metallocene chemistry. We expect that this report will open up previously unexplored synthetic possibilities in d-block transition metal chemistry, including the fields of catalysis and materials chemistry.
Non-volatile optoelectronic memory based on a photosensitive dielectric
Authors: Zhu Rui , Liang Huili , Liu Shangfeng , Yuan Ye , Wang Xinqiang , Ling Francis Chi-Chung , Kuznetsov Andrej , Zhang Guangyu , Mei Zengxia 
Published: September 2023

AbstractRecently, the optoelectronic memory is capturing growing attention due to its integrated function of sense and memory as well as multilevel storage ability. Although tens of states have been reported in literature, there are still three obvious deficiencies in most of the optoelectronic memories: large programming voltage (>20 V), high optical power density (>1 mW cm−2), and poor compatibility originating from the over-reliance on channel materials. Here, we firstly propose an optoelectronic memory based on a new photosensitive dielectric (PSD) architecture. Data writing and erasing are realized by using an optical pulse to switch on the PSD. The unique design enables the memory to work with a programming voltage and optical power density as low as 4 V and 160 µW cm−2, respectively. Meanwhile, this device may be extended to different kinds of transistors for specific applications. Our discovery offers a brand-new direction for non-volatile optoelectronic memories with low energy consumption.
Long-lived spin waves in a metallic antiferromagnet
Authors: Poelchen G. , Hellwig J. , Peters M. , Usachov D. Yu. , Kliemt K. , Laubschat C. , Echenique P. M. , Chulkov E. V. , Krellner C. , Parkin S. S. P. , Vyalikh D. V. , Ernst A. , Kummer K. 
Published: September 2023

AbstractCollective spin excitations in magnetically ordered crystals, called magnons or spin waves, can serve as carriers in novel spintronic devices with ultralow energy consumption. The generation of well-detectable spin flows requires long lifetimes of high-frequency magnons. In general, the lifetime of spin waves in a metal is substantially reduced due to a strong coupling of magnons to the Stoner continuum. This makes metals unattractive for use as components for magnonic devices. Here, we present the metallic antiferromagnet CeCo2P2, which exhibits long-living magnons even in the terahertz (THz) regime. For CeCo2P2, our first-principle calculations predict a suppression of low-energy spin-flip Stoner excitations, which is verified by resonant inelastic X-ray scattering measurements. By comparison to the isostructural compound LaCo2P2, we show how small structural changes can dramatically alter the electronic structure around the Fermi level leading to the classical picture of the strongly damped magnons intrinsic to metallic systems. Our results not only demonstrate that long-lived magnons in the THz regime can exist in bulk metallic systems, but they also open a path for an efficient search for metallic magnetic systems in which undamped THz magnons can be excited.
Locating causal hubs of memory consolidation in spontaneous brain network in male mice
Authors: Li Zengmin , Athwal Dilsher , Lee Hsu-Lei , Sah Pankaj , Opazo Patricio , Chuang Kai-Hsiang 
Published: September 2023

AbstractMemory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved is still poorly understood. Current theory suggests that the hippocampus is pivotal for this reshaping of connectivity. Using fMRI in male mice, we identify that a different set of spontaneous networks and their hubs are instrumental in consolidating memory during post-learning rest. We found that two types of spatial memory training invoke distinct functional connections, but that a network of the sensory cortex and subcortical areas is common for both tasks. Furthermore, learning increased brain-wide network integration, with the prefrontal, striatal and thalamic areas being influential for this network-level reconfiguration. Chemogenetic suppression of each hub identified after learning resulted in retrograde amnesia, confirming the behavioral significance. These results demonstrate the causal and functional roles of resting-state network hubs in memory consolidation and suggest that a distributed network beyond the hippocampus subserves this process.