bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review and Meta-analysis on the Role of Statins in the Prevention of
Mortality Following Pancreatic Cancer
Authors: Anbari Khatereh , Amiri Mehdi Mohammadian , Heidari-Soureshjani Saeid , Sherwin Catherine MT , Kasiri Karamali 
Published: August 2023

Background:
Pancreatic cancer (PC) is a type of cancer with a high incidence and case-fatality rate.

Objective:
This study aimed to evaluate the role of statins in preventing mortality following PC based on scientific
evidence with systematic review and meta-analysis method.

Methods:
This meta-analysis considered studies published from 1980 till the end of 2022 in ISI Web of Science, Scopus,
PubMed, Cochrane, Science Direct, Google Scholar, and Embase databases. Funnel diagrams and Begg's and
Egger's tests were used to assess the publication bias.

Results:
In general, this meta-analysis has included 19 studies (13 cohort studies, 4 case-control, and 2 randomized
clinical trials (RCTs)) and a total of 100,888 patients with PC. The risk of mortality of PC in statin users in total was
0.86 (95% CI: 0.80 - 0.92, P-value <0.001); in the case-control studies, it was equal to 0.53 (0.34-0.83); in the cohort
studies, it was equal to 0.87 (0.82-0.92, P-value <0.001); in RCTs, it was equal to 1.19 (0.99-1.42, P-value <0.001); in
studies with good quality score category, it was equal to 0.92 (0.86-0.99, P-value <0.001), and in articles of the moderate
quality score category, it was equal to 0.73 (0.64-0.84, P-value <0.001). The results of statistical tests indicated the
existence of publication bias (Begg's test (P-value = 0.002) and Egger's test (P-value = 0.004)).

Conclusion:
Statins reduce the risk of mortality in patients with PC. However, no significant relation has been observed
in RCTs. Therefore, it is necessary to be cautious in interpreting the results.
A Novel TSH Receptor Gene Variant Associated with Non-Autoimmune
Hyperthyrotropinemia: A Case Report
Authors: Piva Ilaria , Censi Simona , Manso Jacopo , Barollo Susi , Bertazza Loris , Scaroni Carla , Mian Caterina , Barbot Mattia 
Published: August 2023

Background:
Resistance to TSH is defined as reduced sensitivity to normal, biologically-active TSH, and abnormally high levels of TSH are needed to achieve normal levels of thyroid hor-mones.

Case Presentation:
A 15-year-old female patient, having been treated since childhood with levothyrox-ine for hyperthyrotropinemia was referred to our institution complaining of tachycardia after the levothy-roxine therapy had been increased. Thyroid ultrasound features were normal, and thyroid antibodies were negative. The therapy was gradually tapered in light of the symptoms, although subclinical hypothyroid-ism was evident at thyroid function tests. First-degree relatives were tested for thyroid function, and the father was also found to have a previously-unknown subclinical hypothyroidism. The patient underwent genetic testing for TSH receptor (TSHR) gene mutations, which revealed a gene variant hitherto not described: p.C598R (c.1792T>C). The father was also tested and was found to carry the same mutation, while other first-degree relatives were wild-type for the TSHR gene. An in-silico analysis was performed, which revealed a loss-of-function phenotype corresponding to the described variant, suggesting a novel loss-of-function TSH receptor gene mutation.

Conclusion:
In this case report, we present a novel loss-of-function gene mutation in the TSH receptor gene associated with a TSH resistance phenotype.
Analysis on the Improvement of Energy Efficiency by using its Models in
Wireless Sensor Networks
Authors: B.H. Impa , Anandaraj Shanthi Pichandi , Venkatesh Madhusudhan Mandya 
Published: August 2023

Aims and Background:
A self-configured and infrastructure-less wireless network is
named as a wireless sensor network (WSN), which has the role of monitoring physical or environmental
conditions like sound, motion, temperature, vibration, and pollutants for passing their data
throughout the network to a center of location where the data could be easily observed as well as
analyzed.

Methodology:
In WSN, the small-sized sensor node is working with a very small battery with limited
energy. Replacing the battery or recharging the battery is not feasible, and so, the energyefficient
operation of WSN is the key factor. While designing routing protocols (RPs) for WSNs,
one among the significant goals is energy conservation owing to this lower power. Totally, three
models, namely, state, cluster, and content, were utilized for enhancing energy efficiency (EE). Each
protocol has its own way of routing that varies from the other in terms of the parameters selected or
the approach.

Results:
This paper explicates a survey on WSNs, upgrading EE in WSN based on the state model,
EE improvement in WSN based on the cluster model, and EE enhancement in WSN using a contentbased
model with its performance comparison.

Conclusion:
This paper evaluates the number of cluster heads (CHs) of CADS in different nodes
with different schemes for WSNs and a comparison of the four schemes in WSNs.
Nanocarrier-based Systems for Co-delivery of Drugs in the Management
of Skin Cancer: A Review
Authors: Aqeel Rabia , Hafeez Abdul , Usmani Shazia Afzal 
Published: August 2023

Background:
Cancer of the skin is one of the most frequent kinds of cancer around the globe and has substantial consequences for both public health and the economy. Co-delivery of drugs using nanotechnology are attractive for the reason that they make it possible for the effective targeting of medications with minimal side effects. The aim of the review is to provide an overview on the management of skin cancer with co-delivery via nanocarriers.

Methods:
Using a number of different search engines, search of the published literature was con-ducted using specific key terms such as co-delivery, skin cancer, nanoparticles, liposomes, and ethosomes. The articles were screened on the basis of target purpose and author’s expertise.

Results:
Nanocarriers based co-delivery systems have been found to improve the pharmacokinetic profile of medications, which resulted in enhanced therapeutic effectiveness with reduction in dose and side effects. Lipid based systems and polymeric nanoparticles have been utilized to incorporate different drugs with different physicochemical characteristics for the management of skin cancer.

Conclusion:
The management of skin cancer may be significantly manageable with co-drug deliv-ery approach by integration of nanotechnology. Polymeric nanoparticles, liposomes, ethosomes, nanostructured lipid carriers and polymeric micelles have shown the potential for skin cancer treat-ment.
Efficacy and Safety of the Smallpox Vaccine for Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study
Authors: Yano Rina , Terada-Hirashima Junko , Uemura Yukari , Tomita Noriko , Shimizu Yosuke , Iwasaki Haruka , Okumura Nobumasa , Suzuki Tetsuya , Saito Sho , Ujiie Mugen , Sugiura Wataru , Ohmagari Norio 
Published: August 2023

Background
In May 2022, a case of monkeypox (currently known as “mpox”) with no history of overseas travel was reported in the United Kingdom, followed by reports of infections reported in Europe, the United States, and other countries worldwide. Due to the significant overlap in immune responses among viruses of the genus Orthopoxvirus (including smallpox virus, mpox virus, and vaccinia virus), it is believed that cross-immunity can be achieved by administering the smallpox virus vaccine. In Japan, a smallpox vaccine (LC16m8 strain vaccine) has been approved; however, there was no regulatory approval for the mpox vaccine during the design of this study. Although it is believed that individuals exposed to the mpox virus may receive smallpox vaccination as mpox prophylaxis, the existing evidence is not clear.

Objective
The primary objective was to evaluate the efficacy of the LC16m8 strain vaccine, approved for smallpox in Japan, for postexposure prophylaxis against mpox when administered to close contacts of individuals with mpox. The secondary objective was to investigate the safety of the vaccine for postexposure prophylaxis against mpox.

Methods
The study aimed to enroll 100 vaccinated participants who had been identified as close contacts of individuals with mpox. Consent was obtained, and the participants are inoculated with the vaccine. Daily recordings of symptoms (body temperature, headache, rash, and side effects) were made until day 21 and then again on day 28. Furthermore, additional evaluations of adverse events were performed by the investigators on days 7, 14, 21, and 28. Considering that the maximum incubation period for mpox is 21 days, the primary end point is the presence or absence of the disease 21 days after close contact. The primary analysis focused on cases within 4 days of intense contact as it has been reported that vaccination within this timeframe can reduce the incidence of the disease.

Results
The first trial participant was enrolled on July 28, 2022, and the research period concluded in March 2023. The study results will be published in a peer-reviewed scientific journal.

Conclusions
This study allowed us to investigate the efficacy and safety of the LC16m8 strain vaccine in postexposure prophylaxis against mpox.

Trial Registration
Japan Registry of Clinical Trials jRCTs031220137; https://jrct.niph.go.jp/en-latest-detail/jRCTs031220137

International Registered Report Identifier (IRRID)
DERR1-10.2196/46955
Exploring Patient Needs and Designing Concepts for Digitally Supported Health Solutions in Managing Type 2 Diabetes: Cocreation Study
Authors: Persson Dan Roland , Zhukouskaya Katiarina , Wegener Anne-Marie Karin , Jørgensen Lene Kølle , Bardram Jakob Eyvind , Bækgaard Per 
Published: August 2023

Background
Self-management of the progressive disease type 2 diabetes mellitus (T2DM) becomes part of the daily life of patients starting from the time of diagnosis. However, despite the availability of technical innovations, the uptake of digital solutions remains low. One reason that has been reported is that digital solutions often focus purely on clinical factors that may not align with the patient’s perspective.

Objective
The aim of this study was to develop digital solutions that address the needs of patients with T2DM, designed from the user’s perspective. The goal was to address the patients’ expressed real-world needs by having the users themselves choose the scope and format of the solutions.

Methods
Using participatory methods, we conducted 3 cocreation workshops in collaboration with the Danish Diabetes Association, with 20 persons with T2DM and 11 stakeholders across workshops: user experience designers, researchers, and diabetes experts including a diabetes nurse. The overall structure of the 3 workshops was aligned with the 4 phases of the double diamond: initially discovering and mapping out key experienced issues, followed by a workshop on thematic mapping and definition of key concepts, and succeeded by an exploration and development of 2 prototypes. Subsequently, high-fidelity interactive prototypes were refined as part of the delivery phase, in which 7 formative usability tests were conducted.

Results
The workshops mapped experiential topics over time from prediagnosis to the current state, resulting in a detailed exploration and understanding of 6 themes related to and based on the experiences of patients with T2DM: diabetes care, diabetes knowledge, glucose monitoring, diet, physical activity, and social aspects of diabetes. Two prototypes were developed by the participants to address some of their expressed needs over time related to the 6 themes: an activity-based continuous glucose monitoring app and a web-based guide to diabetes. Both prototypes emphasize periods of structured self-measurements of blood glucose to support evolving needs for self-exploration through distinct phases of learning, active use, and supporting use. Periods of low or intermittent use may thus not reflect a failure of design in a traditional sense but rather be a sign of evolving needs over time.

Conclusions
Our results indicate that the needs of patients with T2DM differ between individuals and change over time. As a result, the suggested digitally supported empowering health prototypes can be personalized to support self-exploration, individual preference in long-term management, and changing needs over time. Despite individuals experiencing different journeys with diabetes, users perceive the self-measurement of blood glucose as a universally useful tool to empower everyday decision-making.
JUSTICES’ FREEDOM OF CONSTITUTIONAL INTERPRETATION METHOD IN THE INDONESIAN CONSTITUTIONAL COURT
Authors: Wibowo Mardian 
Published: August 2023

This paper lays out the method of interpretation used by the Indonesian Constitutional Court in inter-preting the articles within 1945 Indonesian Constitution, primarily in judicial reviews and disputes on the authority of state organ. Among the existing and mostly applied interpretation methods injurisprudence, the Court does not consider it self bound by a single method. The resort to variousinterpretation methods, dependent on the nature of the case at hand, indicates that the Court is progressiveand tends to favour contextual approach. Nonetheless, since the Court is composed of nine differentindividuals, the interpretation approach will largely depend on each Justice’s legal thought. Tulisan ini mencoba menelusuri metode tafsir yang dipergunakan oleh Mahkamah Konstitusi dalam menafsirkan ketentuan Undang-Undang Dasar Negara Republik Indonesia Tahun 1945, terutama dalamperkara pengujian undang-undang dan sengketa kewenangan lembaga negara. Dari beberapa metode tafsiryang ada dan lazim dipergunakan dalam bidang ilmu hukum, ternyata Mahkamah Konstitusi tidak mengikatdirinya pada satu metode tafsir saja. Penggunaan beberapa metode tafsir oleh Mahkamah Konstitusi secarabergantian, tergantung perkara yang dihadapi, menunjukkan sifat progresif dan pemahaman kontekstual.Namun karena Mahkamah Konstitusi adalah kumpulan dari sembilan individu hakim konstitusi makametode tafsir yang dipergunakan sangat tergantung pada kecenderungan dari masing-masing hakim.
MEKANISME sMALL CLAIMs CORTT DALAM MEWUJUDKAN TERCAPAINYA PERADILAN SEDERHANA, CEPAT, DAN BIAYA RINGAN
Authors: Fakhriah Efa Laela 
Published: August 2023

Business disputes require a quick and simple settlement. Such form of settlement could be attained through non-litigation methods or alternative dispute resolution. The result acquired from these methods would be in the form of a decision mutually agreed by the disputing parties. This however, does not have forcible power and often goes unexecuted. Thus, these is a need for a business disputeresolution mechanism agreed by the parties, where its process are concluded in courts under a differentprocedural law than what is normally applicable. Such could be found in small claims court, a quickinformal court to institute civil claims of small monetary value Sengketa bisnis memerlukan penyelesaian secara cepat dan sederhana. Penyelesaian sengketa yang demikian dapat dilakukan melalui penyelesaian sengketa di luar pengadilan (non-litigasi). Namun, hasil yang didapat berupa kesepakatan antara para pihak tidak memiliki daya paksa, sehingga seringkali tidak dilaksanakan. Diperlukan suatu mekanisme penyelesaian sengketa bisnis yangdilakukan secara damai melalui kesepakatan para pihak, yang prosesnya dilakukan di pengadilan dengan prosedur beracara berbeda dari prosedur beracara biasa. Hal tersebut dapat direalisasikan dengan adanyasmall claims court, yang diartikan sebagai suatu pengadilan yang bersifat informal dengan pemeriksaancepat untuk mengambil keputusan atas tuntutan yang nilai gugatannya kecil.
INDONESIA’S RESPONSIBILITY FOR CORAL REEF DAMAGE IN KEPULAUAN SERIBU
Authors: Puspita Natalia Yeti , Windayani Tisa , Swantoro A. Aris 
Published: August 2023

Coral reef is an underwater biodiversity great in value. Sovereignty of the state to explore its natural resources is deeply recognized by international law. On the other hand, the state must also guaranteethe preservation of its natural resources. This research will explain about state responsibility (Indonesia)upon the damage of the coral reefs based on Convention on Biodiversity in Kepulauan Seribu. Terumbu karang merupakan salah satu kekayaan laut yang sangat tinggi nilainya. Hukum internasional mengatur bahwa meskipun suatu negara berdaulat penuh atas wilayahnya, negara tersebut berkewajibanuntuk tidak merusak lingkungan. Penelitian ini menganalisis mengenai tanggung jawab Indonesia sebagainegara peratifikasi Konvensi Keanekaragaman Hayati 1992 sehubungan dengan kerusakan terumbu karang di Kepulauan Seribu.
ANALISIS KRITIK TERHADAP PUTUSAN MAHKAMAH KONSTITUSI NOMOR 36/PUU-X/2012
Authors: Butt Simon , Siregar Fritz Edward 
Published: August 2023

This article discusses the Constitutional Court Judgment No. 36/PUU-X/2012. In this judgment, the majority of the Justices decided that the 1945 Constitution requires the State to exercise direct control over the upstream oil and gas activities. We will criticise the Justices’ deliberation that underlies the decision. The Court failed to shed light on questions pertaining to the legal rationale for ‘five activities’ doctrine that form the framework of ‘State control’ per Article 33 (3) of the Constitution and to the procedures in determining the priority ranking. In addition, the majority Justices are deemed to have left the question of whether the State is able to manage oil and gas industry unanswered. We will also describe how this judgment might result in the declining interest of foreign investors to invest in Indonesia, particularly inthe field of exploration and exploitation of natural resources. Artikel ini membahas Putusan Mahkamah Konstitusi Nomor 36/PUU-X/2012. Dalam putusan tersebut, mayoritas Hakim Konstitusi memutus bahwa UUD NRI Tahun 1945 mensyaratkan Negara secara langsungmenguasai kegiatan hulu Migas. Diuraikan kritik terhadap pertimbangan hukum dari putusan, yakni kelalaian Mahkamah tidak menjelaskan dari mana asal ‘lima kegiatan’ sebagai komponen ‘penguasaan negara’ dalam Pasal 33(3) UUD NRI Tahun 1945, bagaimana menentukan prioritas rangkingnya, dan perihal mayoritas Hakim Konstitusi yang tidak menentukan apakah Negara mampu mengelola industri Migas. Selain itu, diuraikan pula bahwa putusan tersebut berpotensi mengurangi ketertarikan investor asing untuk menanam modalnya di Indonesia, khususnya di bidang eksplorasi dan eksploitasi sumberdaya alam.
MASALAH KEADILAN PELAKSANAAN KEWAJIBAN VIRUS SHARING DALAM SISTEM IHR
Authors: Tjitrawati Aktieva Tri 
Published: August 2023

The implementation of obligations under GISN is considered very unfair by the Government of Indonesia, so the Government stated that it is necessary to halt the delivery of sample virus to WHO until some provisions related to virus sharing and vaccine benefits are amended. In the perception of the Government, this unfair situation is a result of injustice mechanism under the GISN and IHR. New concepts are required to make changes to realize the global influenza disease surveillance system is more fair, equitable, transparent. Pelaksanaan kewajiban virus sharing dalam GISN dianggap sangat tidak adil oleh Pemerintah Indonesia, sehingga perlu diambil langkah penghentian pengiriman sample virus sampai ada perubahan oleh WHO terhadap ketentuan mengenai virus sharing dan vaccine benefits. Persepsi mengenai kerugian yang dialami oleh Pemerintah Indonesia itu merupakan wujud dari ketidakadilan yang terjadi dalam sistem GISN dan IHR. Diperlukan konsep-konsep baru untuk melakukan perubahan untuk mewujudkan sistem pencegahan penularan penyakit influenza global yang lebih berkesetaraan, transparan dan adil.
PUBLIC POLICY VIOLATION UNDER NEW YORK CONVENTION
Authors: Kristy Michelle Ayu Chinta , Jing Zhengzheng 
Published: August 2023

The increasing number of the use of arbitration in Asia has highlighted the significant influence of the recognition and enforcement of arbitral awards. The New York Convention currently becomes the most widely accepted convention to which the courts would refer when recognizing and enforcing foreign arbitral awards. This article would firstly provide a comparative study of the court’s interpretation towards public policy as mentioned under Article V (2) b of the New York Convention between non-arbitration-friendly-law Indonesia and arbitration-friendly-law China. Subsequently, it will discuss whether uniformity in interpreting and reserving public policy is required or not. Peningkatan jumlah penggunaan lembaga arbitrasi di Asia mendorong peningkatan signifikansi pengakuan dan pelaksanaan putusan arbitrasi asing. Konvensi New York saat ini menjadi konvensi yang diterima secara luas dimana dijadikan referensi oleh pengadilan dalam hal pengakuan dan pelaksanaan putusan arbitrasi asing. Artikel ini akan pertama-tama membahas studi perbandingan atas interpretasi pengadilan mengenai penggunaan kebijakan publik sebagaimana tertera pada Pasal V (2) b Konvensi New York antara Indonesia yang hukumnya tidak mendukung dan China dengan hukum yang mendukung pengakuan dan pelaksanaan putusan arbitrasi asing. Apakah keseragaman antar negara dalam menginterpretasi dan menggunakan kebijakan publik diperlukan atau tidak dibahas pada diskusi selanjutnya.
KAJIAN PENGUATAN KOMUNITAS INTELIJEN DAERAH
Authors: Armawi Armaidy 
Published: August 2023

This study aims to disect Presidential Instruction No. 2 of 2002 and the Minister of Home Affairs Regulation No. 11 of 2006 by employing hermeneutic-juridical approach where we performed textual analysis of ‘legal aspirations’ and put it in the context of contemporary condition. We think fortification of the Local Intelligence Community must be attempted. Optimal coordination among Kominda members and coordination between security personnel and common society in responding to threats might affect the stability of local security. Synergic steps among several Kominda members are needed to improve their performance and strengthen the institution. Improvement of performance as well as reinforcement of Kominda members is needed to instill the sense of intelligence. Kajian ini bertujuan menelaah Instruksi Presiden Nomor 5 Tahun 2002 dan Peraturan Menteri Dalam Negeri No. 11 Tahun 2006 dalam rangka penguatan Komunitas Intelijen Daerah. Dalam kajian ini digunakan metode hermeneutik yuridis. Menafsirkan ”kehendak hukum” terhadap makna teks dalam konteks suasana kekinian. Optimalisasi koordinasi di antara anggota Kominda dan adanya kerjasama yang baik antara masyarakat dan aparat keamanan dalam mengantisipasi ancaman, akan membawa dampak pada stabilitas keamanan daerah. Diperlukan langkah yang sinergis dari beberapa anggota Kominda untuk dapat memperbaiki kinerja dan penguatan institusi. Perbaikan kinerja dan penguatan anggota Kominda perlu dilakukan agar memiliki sense of intelligence.