bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplemental Material (for publication) File #1 from Large-scale Radiomic Profiling of Recurrent Glioblastoma Identifies an Imaging Predictor for Stratifying Anti-Angiogenic Treatment Response
Authors: Kickingereder Philipp , Götz Michael , Muschelli John , Wick Antje , Neuberger Ulf , Shinohara Russell T. , Sill Martin , Nowosielski Martha , Schlemmer Heinz-Peter , Radbruch Alexander , Wick Wolfgang , Bendszus Martin , Maier-Hein Klaus H. , Bonekamp David 
Published: April 2023

<p>S1.	Patients epidemiological and clinical characteristics S2.	Image intensity normalization S3.	Schematic of the three dimensional wavelet decompositions applied to each image sequence. S4. Radiomics features S5. List of radiomic features associated with treatment outcome identified using supervised principal component analysis S6.	Supplementary statistical analysis S7. Post-progression therapy after bevacizumab failure</p>
Supplementary Figure 2 from High <i>BCR–ABL/GUS<sup>IS</sup></i> Levels at Diagnosis of Chronic Phase CML Are Associated with Unfavorable Responses to Standard-Dose Imatinib
Authors: Vigneri Paolo , Stagno Fabio , Stella Stefania , Cupri Alessandra , Forte Stefano , Massimino Michele , Antolino Agostino , Siragusa Sergio , Mannina Donato , Impera Stefana Stella , Musolino Caterina , Malato Alessandra , Mineo Giuseppe , Tomaselli Carmela , Murgano Pamela , Musso Maurizio , Morabito Fortunato , Molica Stefano , Martino Bruno , Manzella Livia , Müller Martin C. , Hochhaus Andreas , Raimondo Francesco Di 
Published: April 2023

<p>Figure 2.	Comparison of BCR-ABL/ABL levels at diagnosis in patients achieving an OR or failing IM. Patients were stratified according to their IM response scored following the 2013 ELN criteria (optimal vs failure). BCR-ABL transcripts - using ABL as a reference gene - were determined for each group and depicted as boxplots delimited by the 25th (lower) and 75th (upper) percentile. Horizontal lines above and below each boxplot indicate the 5th and 95th percentile, respectively. Thick lines in each boxplot represent median BCR-ABL/ABL in each patient group. Patients failing IM displayed significantly higher BCR-ABL transcripts at diagnosis (p<0.005).</p>
Data from Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
Authors: Tagawa Scott T. , Milowsky Matthew I. , Morris Michael , Vallabhajosula Shankar , Christos Paul , Akhtar Naveed H. , Osborne Joseph , Goldsmith Stanley J. , Larson Steve , Taskar Neeta Pandit , Scher Howard I. , Bander Neil H. , Nanus David M. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> To assess the efficacy of a single infusion of radiolabeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 (lutetium-177; <sup>177</sup>Lu) by prostate-specific antigen (PSA) decline, measurable disease response, and survival.</p><p><b>Experimental Design:</b> In this dual-center phase II study, two cohorts with progressive metastatic castration-resistant prostate cancer received one dose of <sup>177</sup>Lu-J591 (15 patients at 65 mCi/m<sup>2</sup>, 17 at 70 mCi/m<sup>2</sup>) with radionuclide imaging. Expansion cohort (<i>n</i> = 15) received 70 mCi/m<sup>2</sup> to verify response rate and examine biomarkers.</p><p><b>Results:</b> Forty-seven patients who progressed after hormonal therapies (55.3% also received prior chemotherapy) received <sup>177</sup>Lu-J591. A total of 10.6% experienced ≥50% decline in PSA, 36.2% experienced ≥30% decline, and 59.6% experienced any PSA decline following their single treatment. One of 12 with measurable disease experienced a partial radiographic response (8 with stable disease). Sites of prostate cancer metastases were targeted in 44 of 47 (93.6%) as determined by planar imaging. All experienced reversible hematologic toxicity, with grade 4 thrombocytopenia occurring in 46.8% (29.8% received platelet transfusions) without significant hemorrhage. A total of 25.5% experienced grade 4 neutropenia, with one episode of febrile neutropenia. The phase I maximum tolerated dose (70 mCi/m<sup>2</sup>) resulted in more 30% PSA declines (46.9% vs. 13.3%, <i>P</i> = 0.048) and longer survival (21.8 vs. 11.9 months, <i>P</i> = 0.03), but also more grade 4 hematologic toxicity and platelet transfusions. No serious nonhematologic toxicity occurred. Those with poor PSMA imaging were less likely to respond.</p><p><b>Conclusion:</b> A single dose of <sup>177</sup>Lu-J591 was well tolerated with reversible myelosuppression. Accurate tumor targeting and PSA responses were seen with evidence of dose response. Imaging biomarkers seem promising. <i>Clin Cancer Res; 19(18); 5182–91. ©2013 AACR</i>.</p></div>
Data from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Authors: Lee Chung-Han , Motzer Robert , Emamekhoo Hamid , Matrana Marc , Percent Ivor , Hsieh James J. , Hussain Arif , Vaishampayan Ulka , Liu Sandy , McCune Steven , Patel Vijay , Shaheen Montaser , Bendell Johanna , Fan Alice C. , Gartrell Benjamin A. , Goodman Oscar B. , Nikolinakos Petros G. , Kalebasty Arash Rezazadeh , Zakharia Yousef , Zhang Zhentao , Parmar Hema , Akella Lalith , Orford Keith , Tannir Nizar M. 
Published: April 2023

<div>AbstractPurpose:<p>Glutaminase is a key enzyme, which supports elevated dependency of tumors on glutamine-dependent biosynthesis of metabolic intermediates. Dual targeting of glucose and glutamine metabolism by the mTOR inhibitor everolimus plus the oral glutaminase inhibitor telaglenastat showed preclinical synergistic anticancer effects, which translated to encouraging safety and efficacy findings in a phase I trial of 2L+ renal cell carcinoma (RCC). This study evaluated telaglenastat plus everolimus (TelaE) versus placebo plus everolimus (PboE) in patients with advanced/metastatic RCC (mRCC) in the 3L+ setting (NCT03163667).</p>Patients and Methods:<p>Eligible patients with mRCC, previously treated with at least two prior lines of therapy [including ≥1 VEGFR-targeted tyrosine kinase inhibitor (TKI)] were randomized 2:1 to receive E, plus Tela or Pbo, until disease progression or unacceptable toxicity. Primary endpoint was investigator-assessed progression-free survival (PFS; one-sided <i>α</i> <0.2).</p>Results:<p>Sixty-nine patients were randomized (46 TelaE, 23 PboE). Patients had a median three prior lines of therapy, including TKIs (100%) and checkpoint inhibitors (88%). At median follow-up of 7.5 months, median PFS was 3.8 months for TelaE versus 1.9 months for PboE [HR, 0.64; 95% confidence interval (CI), 0.34–1.20; one-sided <i>P</i> = 0.079]. One TelaE patient had a partial response and 26 had stable disease (SD). Eleven patients on PboE had SD. Treatment-emergent adverse events included fatigue, anemia, cough, dyspnea, elevated serum creatinine, and diarrhea; grade 3 to 4 events occurred in 74% TelaE patients versus 61% PboE.</p>Conclusions:<p>TelaE was well tolerated and improved PFS versus PboE in patients with mRCC previously treated with TKIs and checkpoint inhibitors.</p></div>
Knowledge Of Legal Liability In Sports Among Sports Council Personnel In South-South, Nigeria.
Authors: Alaubi Stanley C. , Nwankwo G. O. 
Published: April 2023

A study on knowledge of legal liability in sports, among male athletes in sport councils in South-South Nigeria. Nine research questions and six null hypotheses were tested at 0.05 alpha levels. The population for this study comprised of all the 3,321 athletes and coaches in south south Nigeria with a sample size of 645 respondents (140 coaches and 505 athletes). The study adopted the cross sectional survey design. The sampling technique used was multi stage sampling procedure. The research instrument was subject to both face and content validation by the researcher’s supervisor and two experts in the field of measurement and evaluation. The reliability coefficient of 0.78 was obtained using the Pearson Product Moment Correlation statistical analysis. The collected data were analyzed using frequency, percentage, mean and standard deviation for the research questions, while multiple regression were used for the testing of the null hypotheses at 0.05 alpha level of significance. The findings established that: 401 (62.2%) Sport personnel in South-South Nigeria possessed good knowledge of legal liability in sports while 244 (37.8%) do not. Based on these findings, it was recommended among others that: Ministry of sport should introduce sporting activities, training and retraining from time to time in order to improve the knowledge of Sports personnel with issues relating to legal liability in sport.
From noun to future tense
Authors: Fries Simon , Halfmann Jakob , Hill Eugen , Hübner Denise 
Published: April 2023

Abstract
This article explores a typologically unusual but recurrent evolutionary path of innovated future formations neglected by typological research: the change of predicative deverbal nouns (understood here in the broad sense of any deverbal nominal expression/formation) – namely agent nouns and participles – denoting actions typical of referents to future verb-forms via hypoanalysis. Starting with an overview of typologically recurrent ways of creating new future formations, the article seeks to demonstrate that the l-future found in the three Nuristani languages Nuristani Kalasha, Ashkun and Katë developed from active participles designating actions typical of their referents. As a typological parallel of this development the Vedic Sanskrit tā́-future is established, and it is shown by the example of the English will + infinitive future and the futurate use of Russian perfective non-past verb-forms how the change of predicative deverbal nouns denoting actions typical of referents to future verb-forms is brought about by means of hypoanalysis.
Barre-fitness as a modern means of improving the health of women in the first period of adulthood
Authors: Inna Krasova  , Alla Semyzorova  , Alfiia Deineko  , Ihor Beihul  , Olena Shyshkina  
Published: April 2023

Purpose: to determine the effect of Barre-fitness classes on the morphofunctional state and physical fitness of women in the first period of adulthood.
Material & Methods: the results of a study of 35 women of the first period of adulthood (21–35 years old) with fitness experience from 6 to 12 months are presented. The female participants, taking into account the age and results of the initial study, were divided into 2 groups: the main group (MG), (n=18) and the control group (CG), (n=17). The women of the control group were engaged in dance fitness, and the women of the main group were engaged in specially designed Barre-fitness exercises. To achieve the set goals, physical development was assessed using anthropometric indicators: body length and weight; waist circumference, hip circumference. To assess the functional capabilities of women, the indicators of the cardiovascular and respiratory systems were studied.
Results: during the study, a statistically significant (p<0.05–0.01) improvement was observed in most of the studied morpho-functional parameters of women in the MG, with the exception of hip circumference, systolic blood pressure and diastolic blood pressure (p>0,05). The indicators of women in the CG also had a positive trend, but did not reach statistically significant differences (p>0,05). As a result of the use of Barre-fitness means, there was a significant statistically significant (p<0,05-0,001) improvement in the results of the physical fitness of women in the MG, with the exception of the “Shuttle run 4×9 m” indicator (p>0,05). The indicators of women in the CG also had a positive trend, but did not reach statistically significant differences (p>0,05).
Conclusions: the conducted study testifies to the positive impact of Barre-fitness classes on the morphofunctional state, the level of physical fitness and the health of women in the first period of adulthood. The obtained results make it possible to recommend Barre-fitness means for training women in fitness clubs and studios, as well as in the educational process of future specialists in physical culture and sports in higher education institutions.
Newspaper Portrayal of Sub-Saharan Immigrants in Morocco
Authors: Dib Salim 
Published: April 2023

Media consumers around the world are regularly confronted with media reports or depictions of migrants crossing the Mediterranean. In Morocco, the situation of those migrants has grabbed media attention, especially in newspapers; hundreds of articles and reports have been written in newspapers, criticizing or denouncing the phenomenon. Although the currently available body research has tended to neglect the linguistic ways in which such media convey meaning along the side of their use of images, little attention has been paid to language-based media. The purpose of this article is to investigate how the media framed the arrival of Sub-Saharan immigrants to Morocco. The focus is mainly on newspaper headlines because they convey the main issue of the news story. The goal is to analyse the headlines of four widely read newspapers Almassae, Assabah, Akhbar Al Yaoum, and Alahdath before the migration reform of 2013. With this in mind, the article applies content analysis methodology to examine how news media framed and portrayed the arrival of ‘African’ immigrants in news headlines.
Combined Effect of Co-trimoxazole Prophylaxis and Safe Water on Diarrhea amongst HIV-Exposed Infants and People Living with HIV/AIDS: A Systematic Review
Authors: Chavura Elton , Singini Wales , Chidya Russel , Mbakaya Balwani Chingatichifwe 
Published: April 2023

Aim: Irrespective of co-trimoxazole prophylaxis, diarrhea among HIV-exposed infants (HEI) and people living with HIV and AIDS (PLWHA) remains unacceptably high. We aimed to determine the combined effect of improved water supply interventions and co-trimoxazole prophylaxis on frequency and severity of diarrhea among HEI and PLWHA. Methods: Using key search terms of safe sanitation, improved water supply, WaSH, co-trimoxazole prophylaxis, HIV-exposed, PLWHA, morbidity, mortality, diarrhea; we searched for published articles in PubMed, EMBASE, PsycINFO, AMED, CINAHL, DOAJ and Google Scholar databases guided by the acceptance practice developed by PROSPERO and COCHRANE. A PRISMA flow diagram was used to explain on the number of articles retrieved, retained, excluded and justifications for every action. A Mixed Method Appraisal Tool (MMAT) was used to assess the quality of the methodology of the selected studies. Results: Safe water and co-trimoxazole together reduced diarrhea episodes by up to 67% (IRR _ 0.33, 95% CI 0.24–0.46, P < 0.0001). The combined interventions resulted in 27% risk reduction in HIV disease progression whilst safe water alone was associated with reductions in the longitudinal prevalence of reported diarrhea of up to 53% among HEI aged ≤2 years (LPR = 0.47, 95% CI: 0.30–0.73, P < 0.001). Conclusion: The combined effect of co-trimoxazole and safe water was significantly higher than when each one of them were to be offered alone. An expanded WaSH response is critical to prevent diarrhea. Registration: CRD42021240512.
Les Accidents Sur les Sites d’Orpaillage Traditionnel : Un Danger Pour la Vision au Niger
Authors: H.Y. Abba Kaka , M. Moussa , M. Boubacar , L. Roufai 
Published: April 2023

Nous avons colligé sur 18 mois 36 yeux ayant été victimes de traumatisme chez les orpailleurs clandestins du Niger. Les atteintes étaient bilatérales dans tous les cas mais volontiers asymétriques et touchent une ou plusieurs structures de l’œil et ses annexes, la présence des corps étrangers multiple était vus dans tous les yeux, nous avons retrouvé 9 cas d’éclatement du globe ayant nécessité une éviscération d’emblée. Il y avaient des lésions d’autres systèmes qui étaient dans 55% maxillo-faciales et dans 27% des fractures de membres. Le pronostic visuel était mauvais dans 94,43% des cas. Le manque d’infrastructures d’exploitation adéquates, la mauvaise manipulation des explosifs artisanaux sont à l’origine des accidents responsables de ces traumatismes. L’absence de structures de premiers soins, le manque de moyens de déplacement compliquent d’avantage les cas graves. Une formation substantielle en matière de santé et de sécurité est à envisager de même que des apprentissages pour aider les travailleurs à comprendre les dangers et les moyens de réduire les risques auxquels ils sont exposés.

Over 18 months, we collected 36 eyes that were victims of trauma among niger illegal gold panners. The lesions were bilateral in all cases but willingly asymmetrical and affect one or more structures of the eye and its adnnexias. The presence of multiple foreign bodies was seen in all eyes, we found 9 cases of bursting of the globe requiring immediate evisceration. Other systems were also affected in 55% maxillofacial and in 27% limb fractures. The visual prognosis was poor in 94.43% of the cases. The lack of adequate operating infrastructure and the improper handling of homemade explosives are at the origin of the accidents responsible for these traumas. The absence of first aid structures and the lack of means of transportation further complicate serious cases. Substantial health and safety training should be considered, as well as apprenticeship to help workers understand the dangers and how to reduce the risks to which they are exposed.
Peran kepala sekolah sebagai pemimpin pendidikan dalam meningkatkan kompetensi pedadogik guru
Authors: Nellitawati Nellitawati , Yunistisa Fadila , Ermita Ermita 
Published: April 2023

Berdasarkan beberapa fenomena yang mucul di lembaga pendidikan yang mengindikasikan bahwa kompetensi pedadogik guru masih rendah. Tujuan penelitian ini adalah untuk menganalisis bagaimana seharusnya peran kepala sekolah sebagai pemimpin pendidikan dalam meningkatkan kompetensi pedadogik guru. Desain penelitian menggunakan metode campuran dilakukan berdasarkan pedoman dalam mencapai tujuan penelitian. Pengumpulan data menggunakan kuesioner dan wawancara pada 261 orang guru, sedangkan informan untuk menjawab pertanyaan dalam wawancara dilakukan pada 12 orang guru. Data kuantitatif dianalisis menggunakan Paket Statistik Ilmu Sosial sedangkan data kualitatif dianalisis menggunakan analisis tematik. Temuan penelitian menunjukkan bahwa peran kepala sekolah sebagai pemimpin pendidikan masih berada pada tingkat sedang, dan aspek kompetensi pedagogik guru di SMK Negeri Padang masih berada pada tingkat sedang. Penelitian ini juga menetapkan bahwa peran kepala sekolah sebagai pemimpin pendidikan secara signifikan mempengaruhi kompetensi pedagogik guru. Oleh karena itu, disarankan kepala sekolah harus lebih aktif dan kreatif berkolaborasi dengan guru dan pemangku kepentingan pendidikan untuk melakukan perbaikan kompetensi pedadogik guru.
Peranan motivasi dan disiplin kerja pada produktivitas karyawan
Authors: Mukrodi Mukrodi 
Published: April 2023

Produktifitas merupakan aktifitas yang dilakuakn seseorang untuk mendapatkan output dari proses yang sudah dilakukan Produktifitas amat sangat penting untuk dilakukan dengan baik dan maksimal agar hasil kerja yang didapat tercapai harapan perusahaan. Untuk meningkatkan produktifitas harus melibatkan berbagai macam elemen faktor mulai dari elemen faktor yang paling kecil sampai pada elemen faktor yang paling besar. Salah satu elemen faktor yang dapat meningkatkan produktifitas karyawan adalah elemen faktor motivasi dan Disiplin, dengan elemen faktor ini diharapkan produktifitas karyawan dapat meningkat. Atas dasar penjelasan ini, maka penelitian bertujuan untuk mengetahui peran motivasi dan disiplin kerja pada produktivitas, baik secara parsial maupun simultan.Metode yang digunakan adalah kuantitatif. Adapun sampel yang digunakan dalam penelitian ini adalah sempel jenuh, yang 74 responden. Analisis data menggunakan uji validitas, uji reliabilitas,uji asumsi klasik, analisis regresi, analisis koefisien korelasi, analisis koefisien determinasi dan uji hipotesis. Hasil penelitian ini menunjukan bahwa motivasi dan disiplin kerja memiliki peran yang signifikan terhadap produktivitas karyawan. Motivasi dan disiplin kerja secara simultan memiliki peran yang signifikan terhadap produktivitas karyawan. Sehingga ketika karyawan memiliki motivasi dan disiplin kerja yang baik maka produktivitas karyawan juga akan semakin maksimal. Namun, ketika motivasi dan disiplin kerja kurang baik maka produktivitas juga akau kurang maksimal.
ANALISIS SEKTOR UNGGULAN DAN POTENSIAL KABUPATEN DAN KOTA DI PULAU SUMBAWA PROPINSI NUSA TENGGARA BARAT
Authors: Wahidin  , Yuniarti Titi , Astuti Endang 
Published: April 2023

Ruang lingkup penelitian ini menganalisis sektor unggulan dan sektor potensial. Tujuannya: untuk mengetahui sektor unggulan dan sektor potensial kabupaten dan kota pulau Sumbawa Propinsi Nusa Tenggara Barat.
Variabel penelitian yaitu: Produk Domestik Regional Bruto, Laju pertumbuhan ekonomi, Pengumpulan data dengan menggunakan metode dokumentasi. Analisis data dengan menggunakan analisis Static Location Quotient (SLQ) dan Analisis Dynamic Location Quotient (DLQ) serta analisis Tipologi Klassen. Hasil analisis SLQ dan DLQ menentukan sektor unggulan dan sektor berpotensi untuk unggul di masa depan. Dan hasil analisis Tipologi Klassen menentukan sektor potensial.
PENGARUH PARIWISATA ALAM TERHADAP KESEJAHTERAAN MASYARAKAT, STUDI KASUS PADA WISATA ALAM DI KELURAHAN TANJUNG KARANG KOTA MATARAM
Authors: Aisyatur Amini Anindya , Suriadi Irwan 
Published: April 2023

Tujuan dari penelitian ini yaitu untuk mengetahui apakah fasilitas wisata, daya tarik wisata, kunjungan wisata berpengaruh terhadap kesejahteraan masyarakat di sekitar lokasi pariwisata alam Kota Mataram, selain itu juga untuk mengetahui apakah apakah fasilitas wisata, daya tarik wisata dan kunjungan wisata, secara bersama-sama berpengaruh terhadap kesejahteraan masyarakat di sekitar lokasi pariwisata alam Kota Mataram. Penelitian ini menggunakan jenis data primer dan data sekunder.sumber data diperoleh dari laporan Badan Pusat Statistik, Dinas Pariwisata Kota Mataram dan profil desa. Teknik pengumpulan data yang dilakukan dimana responden mengisi pertanyaan atau pernyataan tertulis yang ada pada lembar kuisioner. Hasil penelitian menunjukkan variabel fasilitas wisata, daya Tarik dan variabel kunjungan wisata memberikan pengaruh yang positif dan signifikan terhadap kesejahteraan masyarakat di Kawasan objek wisata Kelurahan Tanjung Karang kota mataram
The Effectiveness of Behavioral Therapy Programs in Improving Social Interaction for Children with Attention Deficit Hyperactivity Disorder (ADHD) in Kindergarten
Authors: Abdalla Suham Ahmad 
Published: April 2023

This research aims to determine the impact of the behavioral therapy program on the development of social interaction for children with attention deficit hyperactivity disorder in kindergarten, using the quasi-experimental method, based on a pre- and post-experiment design for one group, and the research sample consists of (14) children, and they were chosen on nonrandomly , children diagnosed with ADHD were distributed into two groups based on their mental age (intelligence). The first group contains (6) children in the early childhood center (Narjis) in Sulaymaniyah, the second group contains (8) children in the primary school (Sarshaqm) from special classes.‏ The Attention Deficit Hyperactivity Disorder Scale (prepared by the researcher) was used to determine the level of disorder for the research model, then a behavioural treatment program consisting of 22 sessions was implemented, and after the program they were also measured in terms of attention deficit and hyperactivity to determine the difference in levels of disorder before and after the program.‏ The ( SPSS) program was also used to analyze the results. The results showed that the behavioral treatment program had a high impact on the social development of the research example, and it had a high effect in reducing the symptoms of attention deficit hyperactivity disorder