bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel trial methodology to test interventions with very large effect sizes: the case of dostarlimab in mismatch repair-deficient, locally advanced rectal cancer
Authors: Powell Kerrington , Olivier Timothée , Prasad Vinay 
Published: December 2022

AbstractDostarlimab (Jemperli, GlaxoSmithKline) is an anti-programmed death receptor-1 monoclonal antibody (anti-PD-1) recently tested in a non-randomized, phase II trial (NCT04165772) which included patients with mismatch repair-deficient, locally advanced rectal cancer. Among the first 12 patients treated with dostarlimab, 100% achieved a clinical complete response with no patients experiencing progression or recurrence to date. Most impressive, none required chemotherapy, radiotherapy or surgery the prevailing standard of care. In this paper, we discuss the impressive results of this trial and how they relate to cancer policy, as well as propose a novel trial methodology to assess dostarlimab.
IL-22 inhibits bleomycin-induced pulmonary fibrosis in association with inhibition of IL-17A in mice
Authors: Qu Ziye , Dou Wencan , Zhang Kexin , Duan Lili , Zhou Dongmei , Yin Songlou 
Published: December 2022

Abstract

Background
Interstitial lung disease, a common extra-articular complication of connective tissue disease, is characterized by progressive and irreversible pulmonary inflammation and fibrosis, which causes significant mortality. IL-22 shows a potential in regulating chronic inflammation and possibly plays an anti-fibrotic role by protecting epithelial cells. However, the detailed effects and underlying mechanisms are still unclear. In this study, we explored the impact of IL-22 on pulmonary fibrosis both in vivo and in vitro.

Methods
To induce pulmonary fibrosis, wild-type mice and IL-22 knockout mice were intratracheally injected with bleomycin followed by treatments with recombinant IL-22 or IL-17A neutralizing antibody. We investigated the role of IL-22 on bleomycin-induced pulmonary fibrosis and the mechanism in the possible interaction between IL-22 and IL-17A. Fibrosis-related genes were detected using RT-qPCR, western blot, and immunofluorescence. Inflammatory and fibrotic changes were assessed based on histological features. We also used A549 human alveolar epithelial cells, NIH/3T3 mouse fibroblast cells, and primary mouse lung fibroblasts to study the impact of IL-22 on fibrosis in vitro.

Results
IL-22 knockout mice showed aggravated pulmonary fibrosis compared with wild-type mice, and injection of recombinant IL-22 decreased the severe fibrotic manifestations in IL-22 knockout mice. In cell culture assays, IL-22 decreased protein levels of Collagen I in A549 cells, NIH/3T3 cells, and primary mouse lung fibroblasts. IL-22 also reduced the protein level of Collagen I in NIH/3T3 cells which were co-cultured with T cells. Mechanistically, IL-22 reduced the Th17 cell proportion and IL-17A mRNA level in lung tissues, and treatment with an IL-17A neutralizing antibody alleviated the severe pulmonary fibrosis in IL-22 knockout mice. The IL-17A neutralizing antibody also reduced Collagen I expression in NIH/3T3 cells in vitro. Knockdown of IL-17A with siRNAs or administration of IL-22 in NIH/3T3 cells and MLFs decreased expression of Collagen I, an effect blocked by concurrent use of recombinant IL-17A.

Conclusions
IL-22 mediated an anti-fibrogenesis effect in the bleomycin-induced pulmonary fibrosis model and this effect was associated with inhibition of IL-17A.
Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
Authors: Kim Taewon , Yi Dahyun , Byun Min Soo , Ahn Hyejin , Jung Joon Hyung , Kong Nayeong , Kim Min Jung , Jung Gijung , Lee Jun-Young , Lee Yun-Sang , Kim Yu Kyeong , Lee Dong Young ,   for the KBASE Research Group
Published: December 2022

Abstract
Background
Hypertension has been associated with Alzheimer’s disease (AD) dementia as well as vascular dementia. However, the underlying neuropathological changes that link hypertension to AD remain poorly understood. In our study, we examined the relationships of a history of hypertension and high current blood pressure (BP) with in vivo AD pathologies including β-amyloid (Aβ) and tau and also investigated whether a history of hypertension and current BP respectively affect the association between Aβ and tau deposition.

Methods
This cross-sectional study was conducted as part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease, a prospective cohort study. Cognitively normal older adults who underwent both Aβ and tau positron emission tomography (PET) (i.e., [11C]-Pittsburgh compound B and [18F] AV-1451 PET) were selected. History of hypertension and current BP were evaluated and cerebral Aβ and tau deposition measured by PET were used as main outcomes. Generalized linear regression models were used to estimate associations.

Results
A total of 68 cognitively normal older adults (mean [SD] age, 71.5 [7.4] years; 40 women [59%]) were included in the study. Neither a history of hypertension nor the current BP exhibited a direct association with Aβ or tau deposition. However, the synergistic interaction effects of high current systolic (β, 0.359; SE, 0.141; p = 0.014) and diastolic (β, 0.696; SE, 0.158; p < 0.001) BP state with Aβ deposition on tau deposition were significant, whereas there was no such effect for a history of hypertension (β, 0.186; SE, 0.152; p = 0.224).

Conclusions
The findings suggest that high current BP, but not a history of hypertension, synergistically modulate the relationship between cerebral Aβ and tau deposition in late-life. In terms of AD prevention, the results support the importance of strict BP control in cognitively normal older adults with hypertension.
Abdominal atherosclerosis is not a risk factor of nonocclusive mesenteric ischemia among critically ill patients: a propensity matching study
Authors: Konan Anhum , Piton Gael , Ronot Maxime , Hassoun Youness , Winiszewski Hadrien , Besch Guillaume , Doussot Alexandre , Delabrousse Eric , Calame Paul 
Published: December 2022

Abstract
Background
Although risk factors of occlusive acute mesenteric ischemia are well known, triggering factors of nonocclusive mesenteric ischemia (NOMI) remain unclear. Alongside to the known risk factors for NOMI, the role of atherosclerosis is not fully elucidated. The purpose of our study was to evaluate whether abdominal atherosclerosis is a risk factor for NOMI.

Methods
From January 2018 to December 2021, all consecutive patients admitted to the intensive care unit who underwent contrast-enhanced CT for suspicion of NOMI were evaluated for inclusion. Clinical and biological data at the time of the CT scan were retrospectively extracted from medical charts and reviewed by a single radiologist. The cohorts were matched by a 1:1 propensity score based on the patient clinical, biological data, and abdominal CT features associated with NOMI. Noncontrast CT acquisitions were used to calculate calcium scores of the abdominal aorta, celiac trunk, superior mesenteric artery (SMA), and common iliac artery according to the Agatston method. Analyses were performed before and after propensity score matching.

Results
Among the 165 critically ill patients included, 59 (36%) had NOMI. Before matching analysis, the SMA and total abdominal Agatston calcium scores were not different between patients without and with NOMI (52.00 [IQR = 0, 473] vs. 137.00 [IQR = 0, 259], P = 0.857, respectively, and 7253 [IQR = 1220, 21738] versus 5802 [IQR = 2075, 15,084]; P = 0.723). The results were similar after matching 38 patients with NOMI and 38 without: 153 [IQR = 0, 665] versus 85 [IQR = 0, 240] (P = 0.312) for the SMA calcium score, and 7915 [IQR = 1812, 21561] versus 4139 [IQR = 1440, 9858] (P = 0.170) for the total abdominal Agatston calcium score.

Conclusion
Our results suggest that atherosclerosis is not a risk factor for NOMI in critically ill patients.
Postoperative pain and pain management and neurocognitive outcomes after non-cardiac surgery: a protocol for a series of systematic reviews
Authors: Khaled Maram , Sabac Denise , Marcucci Maura 
Published: December 2022

Abstract
Background
Postoperative delirium (POD) is common after non-cardiac surgery in older adults and can result in increased risk of adverse outcomes including postoperative cognitive dysfunction (POCD). Pain after surgery is also frequent and can persist as chronic postsurgical pain (CPSP). Evidence is inconsistent and controversial on whether acute and chronic postsurgical pain, and different postoperative pain management strategies (including opioid versus opioid-sparing strategies), is associated with the occurrence of POD and POCD. In this protocol, we propose a series of systematic reviews to answer the following research questions: In adults undergoing non-cardiac surgery, (1) is acute postsurgical pain associated with POD and/or POCD? (2) Are opioid-sparing/avoidance strategies of acute postoperative pain management associated with lower incidence and/or severity of POD and POCD, compared to predominantly opioid-based strategies? (3) Is CPSP associated with POCD? (4) Are opioid-sparing management strategies of CPSP associated with lower incidence and/or severity of POCD compared to standard of care or strategies not aiming at reduced opioid use?

Methods
We will search MEDLINE, EMBASE, Cochrane (CENTRAL), CINAHL, and PSYCHINFO. According to the research question, we will include cohort and case-control studies (questions 1 and 3) or randomized controlled trials and non-randomized studies (questions 2 and 4). The risk of bias will be assessed independently and in duplicate using the revised Cochrane risk-of-bias tool, the Newcastle-Ottawa Scale, and the Joanna-Briggs Institute critical appraisal checklist. Disagreements will be resolved by a third reviewer. Findings will be reported narratively, and where possible and appropriate, meta-analyses will be performed. Certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. We will conduct the reviews in accordance with the guideline of the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols.

Discussion
Our systematic reviews will summarize available evidence to date on the association of postoperative pain and its management strategies with the incidence of POD and POCD in non-cardiac surgery. We will evaluate the existing evidence and its limitations and inform the design of future interventional studies comparing the effects of different pain management strategies on postoperative neurocognitive outcomes.

Systematic review registration
PROSPERO CRD42021192105
Does the country’s political and economic risks trigger risk-taking behavior in the banking sector: a new insight from regional study
Authors: Athari Seyed Alireza , Irani Farid 
Published: December 2022

AbstractThis study specifically explores the effect of domestic political and economic risks on risk-taking in the banking sector for 105 countries operating in six various geographical regions between 2009 and 2017. To the best of our knowledge, this may be the first study that attempts to conduct this relationship from this perspective. Remarkably, the dynamic estimation results underscore that a rise in political and economic risks triggers risk-taking behavior in the banking sector globally, in particular in the OECD High-income region. Besides, the estimation results reveal that capital regulation, market power, and income diversification negatively impact risk-taking while credit risk, inefficiency, financial market development, and deposit insurance have a positive effect on risk-taking behavior. The results also stress that the extent of the effect of determinants and significance level vary by changing the region. The results are robust and have significant implications for policymakers and bank managers.
Degradation pathways for organic matter of terrestrial origin are widespread and expressed in Arctic Ocean microbiomes
Authors: Grevesse Thomas , Guéguen Céline , Onana Vera E. , Walsh David A. 
Published: December 2022

AbstractBackgroundThe Arctic Ocean receives massive freshwater input and a correspondingly large amount of humic-rich organic matter of terrestrial origin. Global warming, permafrost melt, and a changing hydrological cycle will contribute to an intensification of terrestrial organic matter release to the Arctic Ocean. Although considered recalcitrant to degradation due to complex aromatic structures, humic substances can serve as substrate for microbial growth in terrestrial environments. However, the capacity of marine microbiomes to process aromatic-rich humic substances, and how this processing may contribute to carbon and nutrient cycling in a changing Arctic Ocean, is relatively unexplored. Here, we used a combination of metagenomics and metatranscriptomics to assess the prevalence and diversity of metabolic pathways and bacterial taxa involved in aromatic compound degradation in the salinity-stratified summer waters of the Canada Basin in the western Arctic Ocean.ResultsCommunity-scale meta-omics profiling revealed that 22 complete pathways for processing aromatic compounds were present and expressed in the Canada Basin, including those for aromatic ring fission and upstream funneling pathways to access diverse aromatic compounds of terrestrial origin. A phylogenetically diverse set of functional marker genes and transcripts were associated with fluorescent dissolved organic matter, a component of which is of terrestrial origin. Pathways were common throughout global ocean microbiomes but were more abundant in the Canada Basin. Genome-resolved analyses identified 12 clades ofAlphaproteobacteria, includingRhodospirillales, as central contributors to aromatic compound processing. These genomes were mostly restricted in their biogeographical distribution to the Arctic Ocean and were enriched in aromatic compound processing genes compared to their closest relatives from other oceans.ConclusionOverall, the detection of a phylogenetically diverse set of genes and transcripts implicated in aromatic compound processing supports the view that Arctic Ocean microbiomes have the capacity to metabolize humic substances of terrestrial origin. In addition, the demonstration that bacterial genomes replete with aromatic compound degradation genes exhibit a limited distribution outside of the Arctic Ocean suggests that processing humic substances is an adaptive trait of the Arctic Ocean microbiome. Future increases in terrestrial organic matter input to the Arctic Ocean may increase the prominence of aromatic compound processing bacteria and their contribution to Arctic carbon and nutrient cycles.
Stochastic variational variable selection for high-dimensional microbiome data
Authors: Dang Tung , Kumaishi Kie , Usui Erika , Kobori Shungo , Sato Takumi , Toda Yusuke , Yamasaki Yuji , Tsujimoto Hisashi , Ichihashi Yasunori , Iwata Hiroyoshi 
Published: December 2022

Abstract
Background
The rapid and accurate identification of a minimal-size core set of representative microbial species plays an important role in the clustering of microbial community data and interpretation of clustering results. However, the huge dimensionality of microbial metagenomics datasets is a major challenge for the existing methods such as Dirichlet multinomial mixture (DMM) models. In the approach of the existing methods, the computational burden of identifying a small number of representative species from a large number of observed species remains a challenge.

Results
We propose a novel approach to improve the performance of the widely used DMM approach by combining three ideas: (i) we propose an indicator variable to identify representative operational taxonomic units that substantially contribute to the differentiation among clusters; (ii) to address the computational burden of high-dimensional microbiome data, we propose a stochastic variational inference, which approximates the posterior distribution using a controllable distribution called variational distribution, and stochastic optimization algorithms for fast computation; and (iii) we extend the finite DMM model to an infinite case by considering Dirichlet process mixtures and estimating the number of clusters as a variational parameter. Using the proposed method, stochastic variational variable selection (SVVS), we analyzed the root microbiome data collected in our soybean field experiment, the human gut microbiome data from three published datasets of large-scale case-control studies and the healthy human microbiome data from the Human Microbiome Project.

Conclusions
SVVS demonstrates a better performance and significantly faster computation than those of the existing methods in all cases of testing datasets. In particular, SVVS is the only method that can analyze massive high-dimensional microbial data with more than 50,000 microbial species and 1000 samples. Furthermore, a core set of representative microbial species is identified using SVVS that can improve the interpretability of Bayesian mixture models for a wide range of microbiome studies.
Study on the adaptability of traditional architecture in agricultural heritage sites after tourism intervention—a case study of Huzhou Digang Food Street in China
Authors: Wang Ying , Sun Yehong , Gu Xingguo , Wu Wenjie , Yao Cancan 
Published: December 2022

AbstractTraditional architecture in agricultural heritage sites (AHSs) embodies the livelihood of local communities and residents, which is an important part of the AHS. However, with the intervention of tourism, some of the traditional architecture in AHSs has gradually transformed into simple use for tourism, without reflecting the cultural connotations of agricultural heritage systems, as well as the farming wisdom of the AHS. This paper takes Digang Food Street in Huzhou, China as an example, which is in the core protection area of the Huzhou mulberry-dyke and fish-pond system, combining comparative analysis and geographical system analysis to explore the adaptive transformation in decoration, structure, spatial layout and functional form of buildings after the development of the tourism industry. The dynamic relationship among traditional architecture, sustainable development of tourism and conservation of agriculture heritage is also analysed, expecting to provide some experience and reference for the conservation of other AHSs.
Loneliness among surgical patients - measuring levels of loneliness using De Jong Gierveld Loneliness Scale and Revised UCLA Loneliness Scale
Authors: Pohrybieniuk Janina , Krotliński Antoni , Dusińska Aleksandra , Sokołowska Julia , Chabowski Mariusz 
Published: December 2022

Objective: Loneliness is a state that most people will experience during their lifetime. In order to raise awareness of loneliness and its complexity, we attempted to measure the span of loneliness among the surgical patients hospitalized in the Department of Surgery in the 4th Military Teaching Hospital in Wroclaw.
The aim of this study was to establish correlations between loneliness, measured using and four other variables: age, gender, nutritional state and quality of life of surveyed patients.
Material and methods: A total of 100 patients in the Surgery Department in the 4 th Military Teaching Hospital in Wroclaw, Poland, were enrolled. The Mini-Nutritional Assessment (MNA) questionnaire was used to assess their nutritional status; the World Health Organization Quality of Life Scale (WHO-QoL-BREF) was used to assess their quality of life; the De Jong Gierveld Loneliness Scale (DJGLS) and Revised UCLA Loneliness Scale (R-UCLA) were used to assess their loneliness level.
Results:The WHO-QoL-BREF showed that patients’ quality of life (QoL) self-perception was between average and good, health self-perception was average as well. Lowest score of QoL was found in the physical domain whereas the highest was found in the social domain. The MNA showed that 8% of the study group was malnourished, 49% at risk of malnutrition
and 43% displayed a normal nutritional status. 49% of the study group experience loneliness during study by DJGLS. A significant positive correlation between loneliness status and QoL was observed in physical health self-perception (r=0,226, p=0,024). Negative correlation was found between loneliness and QoL in psychological, social and environmental domains (p<0,001).

Conclusions: Loneliness has a significant negative impact on the quality of life.Sex, age and nutritional status can not be predictors of patient’s loneliness.
More than half of patients were in a disturbing nutrition state.
ANALISIS KINERJA RANTAI PASOKAN MENGGUNAKAN METODE SUPPLY CHAIN OPERATION REFERENCE
Authors: Saptiadi Tommy , Koesdiningsih Nining 
Published: December 2022

In recent years, supply chain performance meassurement has received a lot of attention from researchers and practitioners. Effective supply chain management is one of the potential ways to improve supply chain performance and competitive advantage. This study aims to determine the supply chain performance at PT. Bimandiri Agro Sedaya by using the Supply Chain Operation Reference (SCOR) method analyzes the problems that occur in the company, then provides solutions to the problems to improve company performance. This study used a descriptive quantitative research method with the case study technique. Data collection techniques used structured and unstructured interviews with the human resource development members and observations to determine the supply chain condition. The secondary data obtained from the company were company reports and documentation. The results of this performance measurement obtained from the performance attributes in the SCOR are as follow: (1) Perfect Order Fulfillment (POF) with an actual result of 65,91% and a reference value of 80%, (2) Order Fulfillment Cycle Time (OFCT) with the duration of the supply chain process is by the company's target of 1 day, (2) Cost of Good Sold (COGS) of 65,09% still not appropriate with expectations with a reference target of 48% and (4) Cash to Cash Cycle Time (CTCCT) of 14 days still has not reached the company's target of 7 days.
Several records of alien species new to the flora of the United Arab Emirates (UAE)
Authors: Byalt Vyacheslav V. , Korshunov Michail V. 
Published: December 2022

The article presents new records for five alien species previously unknown from the flora of United Arab Emirates (UAE): Euphorbia cyathophora Murr. (Euphorbiaceae), Samolus valerandi L. (Myrsinaceae), Oldenlandia umbellata L. (Rubiaceae), Cardiospermum halicacabum L. (Sapindaceae), and Corchorus aestuans L. (Malvaceae s. l. / Tiliaceae). All of them have been recorded for the first time from the emirate of Fujairah in eastern part of the UAE. Euphorbia cyathophora, which is rare in the country, was found only in “Green Oasis Nursery” at Al Dibba town, Oldenlandia umbellata– found at the beginning of the seefront at Fujairah City, and they are new for the flora of the Arabian Peninsula. Samolus valerandi was found only in the “Desert Nurseries Group store 1 (palms)” at village Al Bidiya, Corchorus aestuans – in private nursery at Al Dibba town, and Cardiospermum halicacabum was found in the Masafi friday market, they are new for the flora of Fujairah and UAE.
Accepted names, synonyms, spatial distribution, habitat preferences, and species taxonomy with remarks on identification and differentiation from the most similar taxa occurring in the study area, as well as the list of localities are presented. The herbarium materials were transferred to the Herbarium of the Komarov Botanical Institute (LE, Saint-Petersburg, Russia), the duplicates – to the Herbarium of Altai State University (ALTB, Barnaul, Russia) and the Scientific Herbarium of Fujairah (FSH, Wadi Wuraya national park, Fujairah, United Arab Emirates).