bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and application of calcium silicate hydrate (C-S-H) nanoparticles for early strength enhancement by eco-friendly low carbon binders
Authors: Plank Johann , Kanchanason Vipasri 
Published: March 2023

Abstract
C-S-H–PCE nanocomposites are known to perform as highly effective seeding materials in Portland cement. Here the effectiveness of a C-S-H–PCE nanocomposite admixture on early strength development of eco-friendly cements (clinker blended with up to 35% fly ash or calcined clay) was investigated. First, C-S-H–PCE nano-composites were synthesized from Ca(NO3)2/Na2SiO3 via a co-precipitation method and their particle size distribution was analyzed. Differently structured PCE comb polymers based on IPEG chemistry were used in the synthesis. Nanofoils of ∼50 nm length were identified as most promising seeding material. Furthermore, addition of such C-S-H–PCE nanofoils was found to substantially increase mortar strength at early ages, particularly after 6–24 h of curing. Isothermal heat flow calorimetry and in-situ XRD measurements indicate that silicate hydration in cement is significantly accelerated. Most remarkably, C-S-H–PCE also was confirmed to speed up the pozzolanic reaction of fly ash and calcined clay and to stimulate the formation of hemicarbo aluminate (Hc), especially in calcined clay cement. Thus, C-S-H–PCE can foster the more widespread use of eco-friendly CEM II/III cements.
A Conserved Role for Stomatin Domain Genes in Olfactory Behavior
Authors: Liang Xiaoyu , Taylor Morgan , Napier-Jameson Rebekah , Calovich-Benne Canyon , Norris Adam 
Published: March 2023

AbstractThe highly-conserved stomatin domain has been identified in genes throughout all classes of life. In animals, different stomatin domain-encoding genes have been implicated in the function of the kidney, red blood cells, and specific neuron types, although the underlying mechanisms remain unresolved. In one well-studied example of stomatin domain gene function, theCaenorhabditis elegansgenemec-2and its mouse homologStoml3are required for the function of mechanosensory neurons, where they modulate the activity of mechanosensory ion channels on the plasma membrane. Here, we identify an additional shared function formec-2andStoml3in a very different sensory context, that of olfaction. In worms, we find that a subset of stomatin domain genes are expressed in olfactory neurons, but onlymec-2is strongly required for olfactory behavior.mec-2acts cell-autonomously and multiple alternatively-spliced isoforms ofmec-2can be substituted for each other. We generate aStoml3knock-out (KO) mouse and demonstrate that, like its worm homologmec-2, it is required for olfactory behavior. In mice,Stoml3is not required for odor detection, but is required for odor discrimination. Therefore, in addition to their shared roles in mechanosensory behavior,mec-2andStoml3also have a shared role in olfactory behavior.
Contrast and Luminance Gain Control in the Macaque’s Lateral Geniculate Nucleus
Authors: Raghavan R. T. , Kelly Jenna G. , Hasse J. Michael , Levy Paul G. , Hawken Michael J. , Movshon J. Anthony 
Published: March 2023

AbstractThere is substantial variation in the mean and variance of light levels (luminance and contrast) in natural visual scenes. Retinal ganglion cells maintain their sensitivity despite this variation using two adaptive mechanisms, which control how responses depend on luminance and on contrast. However, the nature of each mechanism and their interactions downstream of the retina are unknown. We recorded neurons in the magnocellular and parvocellular layers of the lateral geniculate nucleus (LGN) in anesthetized adult male macaques and characterized how their responses adapt to changes in contrast and luminance. As contrast increases, neurons in the magnocellular layers maintain sensitivity to high temporal frequency stimuli but attenuate sensitivity to low-temporal frequency stimuli. Neurons in the parvocellular layers do not adapt to changes in contrast. As luminance increases, both magnocellular and parvocellular cells increase their sensitivity to high-temporal frequency stimuli. Adaptation to luminance is independent of adaptation to contrast, as previously reported for LGN neurons in the cat. Our results are similar to those previously reported for macaque retinal ganglion cells, suggesting that adaptation to luminance and contrast result from two independent mechanisms that are retinal in origin.
Human Tau Aggregates Are Permissive to Protein Synthesis-Dependent Memory inDrosophilaTauopathy Models
Authors: Vourkou Ergina , Rouiz Ortega Eva D. , Mahajan Sumeet , Mudher Amrit , Skoulakis Efthimios M.C. 
Published: March 2023

Tauopathies including Alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration, and intraneuronal aggregates comprised largely of the axonal protein Tau. It has been unclear whether cognitive deficits are a consequence of aggregate accumulation thought to compromise neuronal health and eventually lead to neurodegeneration. We use theDrosophilatauopathy model and mixed-sex populations to reveal an adult onset pan-neuronal Tau accumulation-dependent decline in learning efficacy and a specific defect in protein synthesis-dependent memory (PSD-M), but not in its protein synthesis-independent variant. We demonstrate that these neuroplasticity defects are reversible on suppression of new transgenic human Tau expression and surprisingly correlate with an increase in Tau aggregates. Inhibition of aggregate formation via acute oral administration of methylene blue results in re-emergence of deficient memory in animals with suppressed human Tau (hTau)0N4Rexpression. Significantly, aggregate inhibition results in PSD-M deficits in hTau0N3R-expressing animals, which present elevated aggregates and normal memory if untreated with methylene blue. Moreover, methylene blue–dependent hTau0N4Raggregate suppression within adult mushroom body neurons also resulted in emergence of memory deficits. Therefore, deficient PSD-M on human Tau expression in theDrosophilaCNS is not a consequence of toxicity and neuronal loss because it is reversible. Furthermore, PSD-M deficits do not result from aggregate accumulation, which appears permissive, if not protective of processes underlying this memory variant.SIGNIFICANCE STATEMENTIntraneuronal Tau aggregate accumulation has been proposed to underlie the cognitive decline and eventual neurotoxicity that characterizes the neurodegenerative dementias known as tauopathies. However, we show in three experimental settings that Tau aggregates in theDrosophilaCNS do not impair but rather appear to facilitate processes underlying protein synthesis-dependent memory within affected neurons.
Вплив емоційної праці сімейних лікарів на рівень їх благополуччя та задоволення працею
Authors: Krupskyi Oleksandr P. , Stasiuk Yuliia M. , Hromtseva Olena V. , Lubenets Nataliia V. 
Published: March 2023

Мета роботи: Сімейні лікарі у своїй роботі постійно зіштовхуються із впливом емоцій на їх діяльність. І вплив емоційної праці може бути як негативний, так і позитивний, що безпосередньо впливатиме на оцінку благополуччя та задоволення працею лікарів. В сучасних складних умовах, що є результатом спалаху COVID-19 та війни, робота лікарів супроводжується ще більшим тиском, що і зумовило мету цього дослідження задля виявлення впливу емоційної праці на благополуччя та задоволення працею сімейних лікарів.
Дизайн / Метод / Підхід дослідження: Ми використовували первинні дані, що було зібрано в Центрі первинної медико-санітарної допомоги Підгородненської міської ради Дніпровського району Дніпропетровської області. Для обробки даних було використано двоетапний аналіз моделювання структурних рівнянь.
Результати дослідження: Занадто високоемоційна праця негативно впливає на благополуччя на робочому місці та задоволеність роботою. При цьому задоволеність від праці позитивно впливає на рівень благополуччя на робочому місці.
Теоретична цінність дослідження: Ця робота розширила коло досліджень емоційної праці лікарів, розвинувши наступні аргументи: (1) праця лікарів є високоемоційною; (2) емоційна праця негативно впливає на рівень благополуччя на робочому місці; (3) емоційна праця негативно впливає на задоволеність роботою.
Практична цінність дослідження: Національні медичні програми повинні зосередитися також на програмах емоційної підтримки лікарів поряд з програмами підвищення їх професійного рівня.
Оригінальність / Цінність дослідження: Ми пропонуємо попередній перший доказ впливу емоційної праці на благополуччя та задоволеність роботою сімейних лікарів в Україні.
Обмеження дослідження / Майбутні дослідження: Результати дослідження базуються на малій виборці, що обмежена кількістю лікарів в медичному центрі. Подальші дослідження слід спрямувати на оцінку організаційно системи підтримки сімейних лікарів.
Тип статті: Емпіричний
Developing a Digital-Based Marketing Strategy to Promote Beach Attractions in Indonesia: a Case of Botutonuo Beach in Gorontalo
Authors: Kusuma Citra Aditya , Abid Abid 
Published: March 2023

Purpose: The study reported in this article sought to examine the current state of Botutonuo Beach in the Province of Gorontalo, Indonesia, and develop a digital-based marketing strategy that allows attractions of the beach to be open to potential worldwide tourists. The beach is a popular tourist destination in the province, yet limited information about the beach is available online.
Design/Method/Approach: A design-based research method was employed in the study. To collect data, observations and semi-structured interviews with four locals who were also organizing the beach were used; while for the analysis, a thematic analysis approach was utilized.
Findings: Findings revealed three main themes that best describe aspects of Botutonuo Beach tourism sites that need improvement, namely accessibility, facilities, and convenience, as well as showed what important information that needs to be included on the beach website.
Practical Implications: It is expected that the website can be used by the beach management and local government to foster the promotion of Botutonuo Beach. It is also hoped that the findings, in general, may encourage active participation by the beach visitors and local government to ensure effective management of the beach so that national and international recognition can be obtained.
Originality/Value: The study proposed development of a website that helps in promoting Botutonuo Beach as one of the popular tourist destinations in Gorontalo.
Research Limitations/Future Research: Future research examining the efficacy of this website development is a potential research topic to undertake.
Paper Type: Empirical
JEL Classification: L29, M31, Z33
Botutonuo Beach is a popular tourist destination in the Province of Gorontalo, Indonesia. The locals have primarily been managing the beach for years; however, very little information can be elicited about it online by target visitors from other regions. Therefore, the study reported in this article sought to examine the beach’s current state and develop a digital-based marketing strategy that allows attractions of the beach to be open to potential worldwide tourists. Using a design-based research method, data were collected using observations and semi-structured interviews with four locals who were also organizing the beach. To analyze data, a thematic analysis was used. Findings revealed that several things related to accessibility, facilities, and convenience were crucial aspects to be considered by the beach management. Furthermore, developing a website that helps the management promote the beach’s uniqueness is necessary. The study suggests that the locals, visitors, and government share the responsibility to ensure more effective beach management.
Entrevista a Philippe Meirieu
Authors: Irigoyen Albert 
Published: March 2023

Entrevista a Philippe Meirieu, investigador, polític francès i especialista en ciències de l’educació i pedagogia. Professor emèrit de Ciències de l’Educació a la Universitat Lumière-Lyon-II i doctor honoris causa per la Universitat Lliure de Brussel·les i la Universitat de Mont-real. Ha ensenyat en tots els nivells educatius, ha dirigit l’Institut National de Recherche Pédagogique i ha participat en nombroses reflexions i reformes del sistema educatiu francès.
En l’entrevista, Meirieu esclareix sobre l’aprenentatge en grup, assenyala que, si el docent demana a l’alumnat que faci una tasca grupal, s’estableixen rols entre pensadors, executants, inactius i molestadors. Afirma que la cooperació no esdevé de manera espontània en el grup i en distingeix set nivells de cooperació entre alumnes. Defineix pedagogia diferenciada i descriu la inclusió escolar real. Sobre el tractament de l’actualitat a l’aula, dilucida que l’escola ha de ser prepolítica i crítica, i que també s’ha de tractar la crisi ecològica i els ODS per desenvolupar nous ideals en els joves. Afirma que la tecnologia digital pot ser una eina meravellosa però també un verí. I diferencia el desig de saber i el desig d’aprendre, a la vegada que critica la normalització en l’aprenentatge i explica els beneficis de la normativitat.
Meirieu, autor de nombroses investigacions i llibres publicats en diversos idiomes sobre diferenciació pedagògica i filosofia de l’educació, en l’entrevista valora la directivitat i la no-directivitat en l’ensenyament-aprenentatge, i parla sobre l’Escola Nova, Vigotski, Piaget i Chomsky. Elogia Aronson i el Trencaclosques. I assenyala que el docent ha de tenir un projecte ètic i alhora dominar contingut i tècnica.
Improving Vocabulary Reading Skills with Word Card and Picture Card for Moderate Intellectual Disabilities
Authors: Subasno Yohanes , Nini Klemensia , Densi Consita 
Published: March 2023

Teaching reading functional vocabulary to students with intellectual disability (ID’s) is a challenge for teachers in special schools. They face many obstacles in teaching vocabulary which are caused by various factors, especially student characteristics and learning structures that are less practical and tend to be academic. This study aims to measure the effectiveness of using word cards and picture cards to improve vocabulary reading skills in moderate ID’s students. The type of research applied is single subject research, with multiple baseline across subject designs. The research subjects were two moderately ID’s students in grade 5 and grade 2 SLB-C1 Bhakti Luhur Malang. An instructor and an observer played an important role in this study. The experimental instrument used is Lesson Plan which consists of three units, each teaching two vocabularies. Data analysis is carried out by performing graphical inspections that focus on trend, latency, and level changes. The effectiveness was confirmed by Percentage of All Non-overlapping Data (PAND) in the intervention condition against the baseline-1 condition. The results showed that with the intervention, the target behavior in the form of vocabulary understanding had a trend of grades rising gradually touching a high level of score, and settling at a high level in the baseline-2 condition. The average PAND for subject-1 reached 80.55 percent (effective), and subject-2 reached 96.67 percent (very effective).
Improving Reading Skills Of Beginning Deaf Students Through Global Reflective Maternal Methods Controlled Learning Motivation
Authors: Ningsih Putri Kartika , Efendi Mohammad , Samawi Ahmad 
Published: March 2023

Deaf students have barriers to listening skills, so they need appropriate and structured instruction for teaching early reading. Researchers combined MMR and the global method into the Global Reflective Maternal Method (MMG) for early reading learning for deaf students at the elementary level. Learning motivation needs to be owned by students both intrinsic and extrinsic. Through this research, the researcher wanted to know the effect of the application of MMG on the early reading skills controlled by the learning motivation of the basic level deaf students in SLB Kabupaten Madiun. The real experimental method (true experimental) was applied in this study with a pretest posttest control group design. The results pre-test of the initial reading skills of the control group had an average of 33.5 percent with less criteria, and the experimental group had an average of 28.6 percent with less criteria. The post test of the control group had an average of 32.8 percent with less criteria, and the experimental group had an average of 62.1 percent with sufficient criteria. Based on the significant test through t-test mean pre-test and post-test and compare the results of t-test with t-table 5 percent. The results of the significance test showed t equals 3.42 less than t table 5 percent equals 1.79 then the results were significant. Reinforced the results of the hypothesis test with the results of 3.42 less than 1.79 which means the Global Reflective Maternal Method (MMG) has an effect on the beginning reading skills of basic deaf students in SLB Kabupaten Madiun. The results of the observation of the learning motivation of the control group and the experimental group showed that the motivation of the experimental group was better than the control group. And when compared, the learning outcomes of the experimental group were higher than the control group.
Choice of the optimal metastatic lymph node marking in patients with breast cancer
Authors: Petrovsky A. V. , Soloshchenko A. I. , Gerasimov A. N. , Litvinov R. P. , Karpova M. S. , Ponedelnikova N. V. , Pritula S. I. , Denchik D. A. , Khakurinova N. D. , Soltanov Ts. B. , Stilidi I. S. 
Published: March 2023

Often, neoadjuvant treatment in patients with locally advanced breast cancer leads to complete clinical and pathomorphological regression of not only the primary tumor, but metastatic lymph nodes also. Currently, discussions are ongoing regarding the optimal volume of surgical intervention on regional lymph nodes in this category of patients. As a de-escalation of classical lymphadenectomy, a method of targeted axillary dissection (TAD) is used, which presumes a biopsy of sentinel lymph nodes (SLN) with the removal of a previously marked metastatic lymph node. Our study is aimed at choosing the most optimal method for labeling a metastatic lymph node. The study included 63 patients diagnosed with stage T1–3N1M0 breast cancer, all divided into two comparison groups: 29 patients had a radiopaque label placed in the metastatic lymph node before neoadjuvant therapy, and 33 patients had a radioisotope label (with I125).After the neoadjuvant treatment completion, all patients with complete clinical response in the lymph nodes underwent targeted axillary lymphadenectomy. We evaluated the time of the surgical intervention, the length of the skin incision, the presence of complications when using one or another type of marking. Based on the results of statistical analysis, we propose a variant with a radioisotope label for implementation into the clinical practice. This method, in our opinion, presented the best qualities, reliability and convenience for the surgeon, comfort for the patient.
Pregnancy-associated cancers: a population-based study
Authors: Petkau V.  V. , Kiselyova K.  E. , Kiselev E. A. , Efremov S.  A. , Ankudinov N.  O. , Karimova A.  A. 
Published: March 2023

Introduction: Pregnancy-associated cancers are malignant neoplasms (MNs) diagnosed during pregnancy or within 12 months after delivery. The study aimed to evaluate the prevalence of pregnancy-associated cancers at the population level.Materials and methods: The population database was created from databases of two regional systems: the automated system Pregnancy Monitoring Program and the ONCOR system.Results: Overall, 357 female patients with pregnancy-associated cancers were identified. The incidence rate was 1.659 per 1,000 pregnancies. The most common MN localizations were cervix, breast, thyroid, and ovary. Most female patients were between 45 and 49 years of age. Stage IV breast cancer was identified in a large proportion of women undergoing delivery. Conversely, cervical and ovarian cancers were commonly diagnosed at early stages. The 1-year survival rate of patients with pregnancy-associated cancers was higher than in the entire cancer population.Conclusions: Pregnancy-associated cancers are still a complex and poorly understood issue that requires additional studies, disease-specific monitoring and treatment protocols.
Intensificação de sistemas de produção através da mecanização na região da Transamazônica: limites e possibilidades (Paper 163)
Authors: Simões Aquiles , Schmitz Heribert 
Published: March 2023

O presente estudo é uma contribuição no sentido de fornecer algumas referências acerca do uso da mecanização nas condições reais dos agricultores familiares. Os resultados foram construídos na base de duas pesquisas complementares entre si: o acompanhamento do Projeto de Mecanização desenvolvido pela prefeitura do município de Altamira – PA e; o levantamento de outras experiências desenvolvidas pelos agricultores no município de Uruará - PA. As hipóteses de pesquisa foram definidas considerando a bibliografia existente sobre a transição da agricultura migratória para a agricultura permanente. Verificou-se que o problema da manutenção da fertilidade do solo é um fator limitante, além disso outros aspectos como remuneração baixa do trabalho, diminuição de interesse pela produção de culturas anuais, disponibilidade de área para continuar com a agricultura itinerante, revelaram que a mecanização, naquela região, sofria por falta de demanda. De fato, as condições em termos de evolução dos sistemas agrários não permitem ainda atransição para a agricultura permanente ou a intensificação dos sistemas de produção a partir da mecanização. No entanto, os autores chamam atenção para a relativização dos resultados, em função dos interesses da coletividade e da necessidade de realizar estudos aprofundados com agricultores que estavam praticando tração animal sem ser observado um fracasso visível.Palavras-chave: Mecanização. Agricultores. Fertilidade do solo. Custos da mecanização. Tração animal.
Governança urbana, objetivos do milênio e o pacto global na região metropolitana de Belém (RMB) (Paper 210)
Authors: Vidal Josep Pont 
Published: March 2023

Embora não exista uma única causa e explicação sobre o atraso ou o fracasso na consecução dos Objetivos do Milênio (ODM), são apontadas três razões gerais para o retrocesso ou a falta de avanços significativos dos Objetivos: falhas na governança, a existência de bolsões de pobreza e a negligência emáreas específicas de políticas. A governança urbana aparece como um fator chave capaz de estabelecer vínculos de debate democrático e igualitário com os interlocutores da esfera privada e da sociedade civil, e em conseqüência impulsionar o desenvolvimento na região da Amazônia. Neste escrito se apresentam os resultados da primeira parte da pesquisa, baseada em um estudo de caso. A pesquisa tem como objetivo, a análise do poder local, e dos agentes sociais para participar no diálogo social, a partir de uma tipologia de governança que favoreça esse diálogo. Na primeira parta da pesquisa, em virtude da natureza do tema e dos objetivos da pesquisa será utilizado um Estudo de Caso. Na segunda parte da pesquisa, (ainda em andamento) a análise dos dados realizar-se-á a partir da análise qualitativa por teorização, inspirado na Grounded theory. Palavras-chave: Governança urbana. Pacto global. Região metropolitana.