bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design theory and numerical analysis of earthquake‐resilient joint with slotted bolted connection
Authors: Wu Jianbin , Liu Ruyue , Yan Guiyun , Lai Qiulan 
Published: August 2023

SummaryBolted connections are preferred in prefabricated steel structures with the advantages of quality control and convenient construction. An innovative type of earthquake‐resilient joint with slotted bolted connection (ERJ‐SBC) is proposed to achieve damage control and improve the ductile behavior of steel structures. The bending moment is assumed to be mainly transferred by the flange segments of SBC while the shear force is carried by the web segments. The energy dissipation capacity of ERJ‐SBC is provided by the initial frictional sliding and inelastic axial deformation of SBC under larger displacement. Design theory is proposed to ensure that inelastic deformation is concentrated in SBC while other structural members remain elastic. The influences of the length of slotted holes, bolt pretension, friction coefficient, and the thickness and width of the sliding plate are investigated through the numerical analysis of 44 FE examples. The calculation of the critical length of slotted holes for the ductile rotation behavior of ERJ‐SBC is derived and verified. Results demonstrate that the mechanism of bolted connection shifts from friction resistance to bearing resistance when bolts collide with slotted holes, and the friction slippage behavior with slotted holes benefits the hysteresis behavior, deformation capacity, and rotation behavior. The proposed calculation methods for the mechanical behavior of ERJ‐SBC could achieve good accuracy with simulation results. A reasonably well‐designed ERJ‐SBC could have good bearing capacity and rotation behavior, and it could also achieve damage control.
A new photochromic Mg(II)‐viologen complex with photoswitchable emission and its application in ink‐free printing
Authors: Liu Peng , Liu Teng , Shen Xianfu , Liu Jian‐Jun 
Published: August 2023

AbstractStimulus‐responsive molecular photochromic materials have potential applications in sensor, information storage, and optical switch devices since they undergo reversible color changes upon stimulus from external light. In this work, a viologen‐derived Mg(II) coordination complex with molecular formula [Mg(dpbp)2(H2O)4] (1) has been synthesized from 1‐(3,5‐dicarboxyphenyl)‐4,4′‐bipyridinium chloride (H2dpbp⋅Cl) under solvothermal conditions. Complex 1 has a three‐dimensional viologen‐based hydrogen bond network showing reversible photochromism through radical formation under ultraviolet‐visible light irradiation. Simultaneously, the emission of complex 1 can be reversibly modulated by ultraviolet‐visible light irradiation. Importantly, due to its reversible photochromic properties, practical fading time, and high stability, complex 1 can be used as an ink‐free and erasable printing medium by applying ultraviolet visible light irradiation with a mask.
Conclusions
Authors: Crowell Amber R. , Fossett Mark A. 
Published: August 2023

AbstractWe wrote this book with the central goal of documenting patterns and trends of racial and ethnic segregation across communities and over time in the United States using refined methods of measurement analysis, which can sometimes be expected to change what we thought we knew from past research and at other times add more to our understanding of established patterns. In making this our goal, we produced several contributions that happily build continuity with past research and set a foundation for future research, which we can expect to come in waves each time there is a decennial census data release. First and foremost, by using measures of segregation that are free of index bias and specifically employing the separation index, a measure of evenness that can dependably signal whenprototypicalpatterns of segregation are occurring, we were able to reanalyze and describe patterns and levels of racial and ethnic residential segregation across the United States and over time. We are not the first to describe patterns of segregation, here operationalized as the uneven distribution of two groups across neighborhood-level spatial units, across communities and over time in the United States. But we are the first to simultaneously use measures that are corrected for index bias, measure segregation of households rather than persons, and expand our analysis to not only metropolitan areas but also micropolitan areas and noncore counties. Our findings should be viewed as reliable benchmarks for descriptive analyses of racial and ethnic residential segregation across a broad range of communities moving forward and should also be taken instructively, as they demonstrate the application of the methodological changes that we recommend should be the standard for residential segregation measurement. We also use Fossett’s (2017) difference-of-means calculation of segregation indices to demonstrate new approaches for linking locational attainments to residential segregation patterns, situating segregation quantitatively as a stratification outcome. In this final chapter, we describe how this study establishes continuity with past research and sets the path for residential segregation research in the future.
Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids
Authors: Yang Qiwei , Ali Mohamed , Treviño Lindsey S. , Mas Aymara , Al-Hendy Ayman 
Published: August 2023

Abstract
Background
The stage, when tissues and organs are growing, is very vulnerable to environmental influences, but it’s not clear how exposure during this time causes changes to the epigenome and increases the risk of hormone-related illnesses like uterine fibroids (UFs).

Methods
Developmental reprogramming of myometrial stem cells (MMSCs), the putative origin from which UFs originate, was investigated in vitro and in the Eker rat model by RNA-seq, ChIP-seq, RRBS, gain/loss of function analysis, and luciferase activity assays.

Results
When exposed to the endocrine-disrupting chemical (EDC) diethylstilbestrol during Eker rat development, MMSCs undergo a reprogramming of their estrogen-responsive transcriptome. The reprogrammed genes in MMSCs are known as estrogen-responsive genes (ERGs) and are activated by mixed lineage leukemia protein-1 (MLL1) and DNA hypo-methylation mechanisms. Additionally, we observed a notable elevation in the expression of ERGs in MMSCs from Eker rats exposed to natural steroids after developmental exposure to EDC, thereby augmenting estrogen activity.

Conclusion
Our studies identify epigenetic mechanisms of MLL1/DNA hypo-methylation-mediated MMSC reprogramming. EDC exposure epigenetically targets MMSCs and leads to persistent changes in the expression of a subset of ERGs, imparting a hormonal imprint on the ERGs, resulting in a “hyper-estrogenic” phenotype, and increasing the hormone-dependent risk of UFs.
Therapie der Zystitis mit Nitroxolin – NitroxWin
Authors: Wagenlehner Florian , Kresken Michael , Wohlfarth Esther , Bahrs Christina , Grabein Beatrice , Strohmaier Walter Ludwig , Naber Kurt G. 
Published: August 2023

Zusammenfassung
Hintergrund
Nitroxolin zählt entsprechend der AWMF-S3-Leitlinie zu den Antibiotika der ersten Wahl für die Behandlung der unkomplizierten Zystitis (UZ) bei Frauen. Unter Real-world-Bedingungen sollte die klinische Effektivität von Nitroxolin in einer prospektiven, multizentrischen, nicht-interventionellen Studie (NIS) und die Resistenz von Escherichia coli gegenüber Nitroxolin überprüft werden.

Material und Methoden
Patientinnen mit UZ und einer Therapie mit Nitroxolin (empfohlene Dosierung 3 × täglich 250 mg über 5 Tage) wurden von Urologen, Allgemeinmedizinern und hausärztlich tätigen Internisten deutschlandweit von April bis Dezember 2022 rekrutiert und über einen Zeitraum von 21–28 Tagen nachverfolgt. Die Diagnosestellung und der Therapieverlauf wurden mit Hilfe des ACSS-Fragebogens und anhand von Laboruntersuchungen (Leukozyturie etc.) beurteilt. Unabhängig von der NIS wurden im Rahmen einer bundesweiten Resistenz-Surveillance im Zeitraum 2019–20 in 23 Laboratorien Escherichia-coli-Urinisolate gesammelt und deren Empfindlichkeit gegenüber Nitroxolin getestet.

Ergebnisse
Von 316 Patientinnen im mittleren (SD) Alter von 57,2 (±20,4; Median 62,5) Jahren, die in die NIS eingeschlossen wurden, war die Therapie zum Zeitpunkt des „test of cure“ bei 193/248 (86,3 %) in der Per-protocol-Gruppe und 193/263 (81,4 %) in der Intention-to-treat-Gruppe klinisch erfolgreich. 96 % der Patientinnen bewerteten die Verträglichkeit von Nitroxolin als „sehr gut“ oder „gut“. Alle 272 getesteten Escherichia-coli-Isolate waren Nitroxolin-sensibel.

Schlussfolgerung
Nitroxolin erzielte sehr gute klinische Ergebnisse in der NIS und wies eine sehr günstige Resistenzsituation bei Escherichia-coli-Urinisolaten auf. Nitroxolin kann weiterhin als Antibiotikum der ersten Wahl zur Behandlung der UZ der Frau empfohlen werden.

Graphic abstract
The contribution of muscle spindles to position sense measured with three different methods
Authors: Roach Christopher , Love Christopher , Allen Trevor , Proske Uwe 
Published: August 2023

AbstractThe sense of limb position is important, because it is believed to contribute to our sense of self-awareness. Muscle spindles, including both primary and secondary endings of spindles, are thought to be the principal position sensors. Passive spindles possess a property called thixotropy which allows their sensitivity to be manipulated. Here, thixotropic patterns of position errors have been studied with three commonly used methods of measurement of position sense. The patterns of errors have been used as indicators of the influence exerted by muscle spindles on a measured value of position sense. In two-arm matching, the blindfolded participant indicates the location of one arm by placement of the other. In one-arm pointing, the participant points to the perceived position of their other, hidden arm. In repositioning, one of the blindfolded participant’s arms is placed at a chosen angle and they are asked to remember its position and then, after a delay, reproduce the position. The three methods were studied over the full range of elbow angles between 5° (elbow extension) and 125° (elbow flexion). Different outcomes were achieved with each method; in two-arm matching, position errors were symmetrical about zero and thixotropic influences were large, while in one-arm pointing, errors were biased towards extension. In repositioning, thixotropic effects were small. We conclude that each of the methods of measuring position sense comprises different mixes of peripheral and central influences. This will have to be taken into consideration by the clinician diagnosing disturbances in position sense.
The difference in leg lengths following total knee replacement for patients with severe osteoarthritic deformity
Authors: Hafez Mahmoud A. , Mosa Mohamed , Abdelaal Ahmed , Moghny Ahmed , Makram Abdelrahman M. 
Published: August 2023

Abstract
Purpose
Increased height after total knee replacement surgery (TKR) may offer patients higher satisfaction as well as the quality of life. Therefore, in this paper, we aim to document the changes in leg length after TKR in patients with severe bilateral deformities.

Methods
The data of 61 patients were collected from the Egyptian Community Arthroplasty Register; of them, 21 patients had unilateral TKR while 40 had bilateral simultaneous TKR. The patterns of changes in height of 101 osteoarthritic knees were followed up for 1 year after having TKR. All patients had standing leg X-rays, before and after surgery, to document the length of the femur and tibia before and after TKR. Correlations were assessed using the two-sample t-test.

Results
The sample was mostly females (56/61, 91.8%). The distribution of the operated side was nearly equal (right knee was 47/101, 46.5%). The overall average leg length difference was 5.4 (SD = 2.3); for the unilateral group, the average was 4.6 (SD = 2.6); and for the bilateral group, the average was 5.6 (SD = 2.3), p = 0.119. We found that leg length may differ according to the varus deformity angle (p < 0.001) as well as fixed flexion deformity (p < 0.001).

Conclusions
Leg length increased significantly 1 year after TKR. However, there is not enough evidence to suggest that the bilateral group had a greater height increase when compared to the unilateral group.
Predictors of very early death in acute promyelocytic leukemia: a retrospective real-world cohort study
Authors: Infante Joana , Esteves Graça , Raposo João , de Lacerda João Forjaz 
Published: August 2023

AbstractEarly death (ED) is still the major obstacle to cure in acute promyelocytic leukemia (APL). Most studies focus on 30-day ED; however, little is known on predictors of death before starting APL treatment (very early death — VED) and on predictors of 7-day ED, the period with most deaths due to thrombohemorrhagic diathesis. We hypothesized whether the severity of the coagulopathy of APL could predict VED and 7-day ED. We also aimed to evaluate other characteristics associated with these outcomes. We undertook a retrospective, single-center observational study including newly diagnosed APL patients admitted to our institution between January 2000 and November 2022. Baseline demographical, clinical, and laboratorial data were collected. Statistical analysis was performed using Stata. One hundred four patients were included. The VED rate was 4.8%. A DIC Score ≥ 7 (p = 0.045), serum creatinine > 1.5 mg/dL (p < 0.001%), a DIC Score ≥ 6 within 24 h (p = 0.009), and mechanical ventilation (p < 0.001) were associated with VED. The 7-day ED rate was 12.5%. High-risk (p = 0.007) and hypogranular APL (p = 0.029), DIC Score at diagnosis (p = 0.047), DIC Score ≥ 7 (p = 0.043), DIC Score ≥ 6 within 24 h (p = 0.025), PT prolongation > 6 s (p = 0.002), and creatinine > 1.5 mg/dL (p = 0.004) were associated with 7-day ED. However, only elevated creatinine emerged as an independent predictor of 7-day ED (OR 21.4; p = 0.008). Our study shows that in patients with APL, an elevated creatinine at diagnosis strongly predicts for 7-day ED. A DIC Score ≥ 7 and a Score that remains ≥ 6 within 24 h and a serum creatinine > 1.5 mg/dL significantly associated with VED.
Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction cancer not treated with neoadjuvant chemotherapy
Authors: Shiomi Shinichiro , Yagi Koichi , Iwata Ryohei , Yajima Shoh , Okumura Yasuhiro , Aikou Susumu , Yamashita Hiroharu , Nomura Sachiyo , Seto Yasuyuki 
Published: August 2023

Abstract
Background
Lymphatic flow mapping using near-infrared fluorescence (NIR) imaging with indocyanine green (ICG) has been used for the intraoperative prediction of lymph node metastasis in esophageal or esophagogastric junction cancer. However, a consistent method that yields sufficient diagnostic quality is yet to be confirmed. This study explored the diagnostic utility of our newly established lymphatic flow mapping protocol for predicting lymph node metastasis in patients with esophageal or esophagogastric junction cancer.

Methods
We injected 0.5 mL of ICG (500 μg/mL) into the submucosal layer at four peritumoral points on the day before surgery for 54 patients. We performed lymphatic flow mapping intraoperatively using NIR imaging. After determining the NIR status and presence of metastases, evaluable lymph node stations on in vivo imaging and all resected lymph nodes were divided into four categories: ICG+meta+ (true positive), ICG+meta− (false positive), ICG−meta+ (false negative), and ICG−meta− (true negative).

Results
The distribution of ICG+ and meta+ lymph node stations differed according to the primary tumor site. Sensitivity and specificity for predicting meta+ lymph nodes among ICG+ ones were 50% (95% CI 41–59%) and 75% (73–76%), respectively. Predicting meta+ lymph node stations among ICG+ stations improved these values to 66% (54–77%) and 77% (74–79%), respectively. Undergoing neoadjuvant chemotherapy was an independent risk factor for having meta+ lymph nodes with false-negative diagnoses (odds ratio 4.82; 95% CI 1.28–18.19). The sensitivity of our technique for predicting meta+ lymph nodes and meta+ lymph node stations in patients who did not undergo neoadjuvant chemotherapy was 79% (63–90%) and 83% (61–94%), respectively.

Conclusion
Our protocol potentially helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction cancer undergoing esophagectomy who did not undergo neoadjuvant chemotherapy.

Graphical abstract
Gasless laparoscopy in rural India-registry outcomes and evaluation of the learning curve
Authors: Aruparayil N. , Gnanaraj J. , Mishra A. , Bains L. , Corrigan N. , Brown J. , Ensor T. , King R. , Shinkins B. , Jayne D. 
Published: August 2023

Abstract
Background
A program of gasless laparoscopy (GL) has been implemented in rural North-East India. To facilitate safe adoption, participating rural surgeons underwent rigorous training prior to independent clinical practice. An online registry was established to capture clinical data on safety and efficacy and to evaluate initial learning curves for gasless laparoscopy.

Methods
Surgeons who had completed the GL training program participated in the online RedCap Registry. Patients included in the registry provided informed consent for the use of their data. Data on operative times, conversion rates, perioperative complications, length of stay, and hospital costs were collected. Fixed reference cumulative sum (CUSUM) model was used to evaluate the learning curve based on operative times and conversion rates published in the literature.

Results
Four surgeons from three rural hospitals in North-East India participated in the registry. The data were collected over 12 months, from September 2019 to August 2020. One hundred and twenty-three participants underwent GL procedures, including 109 females (88.6%) and 14 males. GL procedures included cholecystectomy, appendicectomy, tubal ligation, ovarian cystectomy, diagnostic laparoscopy, and adhesiolysis. The mean operative time was 75.3 (42.05) minutes for all the surgeries. Conversion from GL to open surgery occurred in 11.4% of participants, with 8.9% converted to conventional laparoscopy. The main reasons for conversion were the inability to secure an operative view, lack of operating space, and adhesions. The mean length of stay was 3 (2.1) days. The complication rate was 5.7%, with one postoperative death. The CUSUM analysis for GL cholecystectomy showed a longer learning curve for operative time and few conversions. The learning curve for GL tubal ligation was relatively shorter.

Conclusion
Gasless laparoscopy can be safely implemented in the rural settings of Northeast India with appropriate training programs. Careful case selection is essential during the early stages of the surgical learning curve.
On Positivity Sets for Helmholtz Solutions
Authors: Kow Pu-Zhao , Salo Mikko , Shahgholian Henrik 
Published: August 2023

AbstractWe address the question of finding global solutions of the Helmholtz equation that are positive in a given set. This question arises in inverse scattering for penetrable obstacles. In particular, we show that there are solutions that are positive on the boundary of a bounded Lipschitz domain.
Efficient Multilayers Organic Solar Cells with Hybrid Interfacial Layer-based P3HT and CuO Nanoparticles
Authors: Agha M. , El-Kemary M. , Oraby A. H. , Salim E. 
Published: August 2023

AbstractOrganic solar cell (OSC) devices suffer from low power conversion efficiency (PCE) due to deep trap states that absorb photogenerated charges, act as recombination centers, and reduce charge collection. To further improve the PCE, an optimized hole transport layer (HTL) must be engineered for efficient hole transport and reduced deep trap states. A hybrid HTL consisting of organic and inorganic materials was formed using a combination of CuO nanoparticles (NPs) having an average size of 50 nm and poly(3-hexylthiophene) (P3HT). The hybrid HTL was used in the fabrication and characterization of an inverted OSC device structure. In consequence, the incorporation of CuO-NPs into the P3HT resulted in an increase of 8.66% in photocurrent density. Additionally, the PCE increased from 3.77 to 4.22% while the open circuit voltage (Voc) was maintained. The higher hole mobility obtained for the optimum device using the charge extraction by increasing voltage (CELIV) measurement was 8.47 × 10− 4 cm2 V− 1 s− 1. This highlights the potential of designing novel organic solar cells with inorganic nanoparticles, offering enhanced performance and efficiency.
Impact of geriatric co-management on outcomes in hospitalised cardiology patients aged 85 and over
Authors: Raijmann Renee C. M. A. , Koek Huiberdina L. , Emmelot-Vonk Marielle H. , Swaving Joost G. E. , Agema Willem R. P. , Kerckhoffs Angèle P. M. , Keijsers Carolina J. P. W. 
Published: August 2023

Abstract
Objective
Cardiovascular disease and frailty are common among the population aged 85+. We hypothesised these patients might benefit from geriatric co-management, as has been shown in other frail patient populations. However, there is limited evidence supporting geriatric co-management in older, hospitalised cardiology patients.

Methods
A retrospective cohort study was performed in a large teaching hospital in the Netherlands. We compared patients aged 85 and over admitted to the cardiology ward before (control group) and after the implementation of standard geriatric co-management (intervention group). Data on readmission, mortality, length of stay, number of consultations, delirium, and falls were analysed.

Results
The data of 1163 patients were analysed (n = 542 control, n = 621 intervention). In the intervention group, 251 patients did not receive the intervention because of logistic reasons or the treating physician’s decision. Baseline characteristics were comparable in the intervention and control groups. Patients in the intervention group had a shorter length of stay (−1 day, p = 0.01) and were more often discharged to a geriatric rehabilitation facility (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.10–3.54, p = 0.02) compared with the control patients. Other outcomes were not significantly different between the groups.

Conclusions
After implementation of standard geriatric co-management for hospitalised cardiology patients aged 85 and over, the length of hospital stay shortened and the number of patients discharged to a geriatric rehabilitation facility increased. The adherence to geriatric team recommendations was high. Geriatric co-management would appear to optimise care for older hospitalised patients with cardiac disease.