bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Nuvastatic™ in Improving Cancer-related Fatigue: A Phase II Multicenter Randomized Controlled Trial
Authors: Ng M , AMS Abdul , Yee S M , Natesan V , Ahamed Mohamed B K , Ashok G , Al- Fouad S.R. , Parish C. , Dalal M. , Long C M , V Mansoureh Nazari. , Khan Shamsuddin Sultan , STN Balkees , Sultan Hameed , Babu K Govind , Majid Abdul AS 
Published: March 2023

Abstract

Puropse
We evaluated the efficacy and safety of Nuvastatic™ in improving cancer-related fatigue (CRF) among cancer patients.
Methods
This multicenter randomized double-blind placebo-controlled phase-2 trial included 110 solid malignant tumor patients (stage I–IV) undergoing chemotherapy. They were randomly selected and provided oral Nuvastatic™ 1000 mg (N = 56) or placebo (N = 54) thrice daily for 9 weeks. The primary outcomes were fatigue (Brief Fatigue Inventory [BFI]) and Visual Analog Scale for Fatigue [VAS-F]) scores measured before and after intervention at baseline and weeks 3, 6, and 9. The secondary outcomes were mean group difference in the vitality subscale of the Medical Outcome Scale Short Form-36 (SF-36) and urinary F2-isoprostane concentration, Eastern Cooperative Oncology Group scores, and biochemical and hematologic parameters. Clinical outcomes were assessed using two-way repeated-measures analysis of variance on intention-to-treat population.
Results
The Nuvastatic™ group exhibited an overall decreased fatigue score compared with the placebo group. The BFI estimated mean difference (eMD) was 15.29 (95% CI: 12.77–17.82) and VAS-F eMD was 11.19 (95% CI: 8.06–14.32) were significantly different between two groups at week 9 (p < 0.001). The overall treatment effect was significant for BFI (p < 0.001) and VAS-F (p < 0.001). Within group assessment showed significant fatigue improvement in both the groups (p < 0.001). Quality of life was significantly improved in the Nuvastatic™ group with eMD of 70.81, (95% CI: 58.34–83.28; p < 0.001) SF-36 scores. Additionally, F2-isoprostane concentrations significantly decreased in the Nuvastatic™ group (p = 0.006). Reported adverse events were vomiting (0.9%), fever (5.4%), and headache (2.7%).
Conclusion
Nuvastatic™ is an effective adjuvant for CRF in solid tumor patients.
Spatial patterns suggest movement of the filbert bud mite (Phytoptus avellanae) between plants and overwintering infestations in a hazelnut (Corylus spp.) orchard
Authors: Shanovich Hailey N. , Chediack Ariadna , Fischbach Jason A. , Aukema Brian H. 
Published: March 2023

Abstract
Phytoptus avellanae is an eriophyid mite that feeds on and damages the vegetative and floral buds of hazel (Corylus) species by forming galls that impact hazelnut yield. Phytoptus avellanaehas been identified on hybrid hazels (European hazel, Corylus avellana × American hazel, Corylus americana) that have been developed for hazelnut production in the eastern United States and Canada, but year-to-year variation in distribution and severity of P. avellanae damage within a field has not been studied. Additionally, whether P. avellanae differentially infests and damages the hybrid hazel plants vs. native Corylus americana plants is unknown. We assessed the spatial trends and species preferences of P. avellanae within a mixed-species field of hazels over a four-year period. All hazels were surveyed for galls caused by P. avellanae each spring and assigned a qualitative damage rating. We found that damage from P. avellanaewas higher on hybrid hazel plants than on C. americana in each year of the study. In general, P. avellanae ratings increased towards the center of the field in most years. Our results showed that plants surrounded by infested neighbors often had higher damage ratings, suggesting that P. avellanae moves between adjacent plants. Understanding the within field distribution and host-plant preferences of P. avellanae will contribute to the development of scouting and management recommendations, provide insight on risk of mite movement between wild hazels and hybrid plantings in North America, and inform breeding efforts for this harmful pest.
Effects of Epoxide Content and Blend Ratios on Properties of Dynamically Cured Epoxidized Natural Rubber/Poly(ether-block-amide) Copolymer Blends
Authors: Kaesaman Azizon , Romin Rawviyanee , Nakason Charoen 
Published: March 2023

Abstract

ENR with varying levels of epoxide groups ranging from 10 to 50 mol% was prepared in-house and later dynamically phenolic vulcanized by blending it with poly(ether-block-amide) copolymer (PEBA) at 160°C. The results revealed that the thermoplastic vulcanizates (TPVs) of ENR/PEBA blends exhibited a sea-island morphology. Increasing the epoxide content and PEBA proportion improved the strength properties, including higher Young's modulus (stiffness), toughness, tensile properties, and hardness. Additionally, increasing the epoxide content and ENR proportion in the TPVs resulted in decreased tension set values, indicating improved elastic properties. This is attributed to the interaction between the polar groups present in the phenolic-cured ENR domains and the PEBA molecules. This also caused a decrease in the size of the ENR domains dispersed in PEBA matrix as the content of epoxide groups increased. This effect, in turn, contributed to the enhancement of interfacial adhesion between the ENR domains and PEBA interfaces, leading to the observed improvements in the strength and elastic properties of the TPVs. Additionally, an increase in the epoxide content correlated with a decrease in Tan δ and tension set, further supporting the observed improvements in strength and elasticity. In addition, a single glass transition temperature (Tg) was observed in the ENR/PEBA blends, whereas two Tgs were observed in pure PEBA. The presence of a single Tg in the ENR/PEBA blend is attributed to the overlapping of the Tg of the ENR and PEBA immiscible blend components.
Multichannel Sensorimotor Integration with a Dexterous Artificial Hand
Authors: Abd Moaed A. , Engeberg Erik D. 
Published: March 2023

Abstract
Background People use their hands to perform sophisticated tasks like playing a musical instrument by integrating manifold and diverse sensations of touch with motor control strategies. In contrast, prosthetic hands lack the capacity for multichannel haptic feedback and multitasking functionality remains rudimentary. There is a dearth of research exploring the potential of upper limb absent (ULA) people to integrate multiple channels of haptic feedback into dexterous prosthetic hand control strategies. Methods In this paper, we designed a novel experimental paradigm for three ULA people and nine additional subjects to investigate their ability to integrate two simultaneously activated channels of context-specific haptic feedback into their dexterous artificial hand control strategies. Artificial neural networks (ANN) were designed for pattern recognition of the array of efferent electromyogram signals that controlled the dexterous artificial hand. ANNs were also used to classify the directions that objects were sliding across two tactile sensor arrays on the index (I) and little (L) fingertips of the robotic hand. The direction of sliding contact at each robotic fingertip was encoded by different stimulation frequencies of wearable vibrotactile actuators for haptic feedback. The subjects were tasked with implementing different control strategies with each finger simultaneously depending upon the perceived directions of sliding contact. This required the 12 subjects to concurrently control individual fingers of the artificial hand by successfully interpreting two channels of simultaneously activated context-specific haptic feedback. Results Subjects were able to accomplish this complex feat of multichannel sensorimotor integration with an overall accuracy of 95.53% ± 0.23%. While there was no statistically significant difference in the classification accuracy between ULA people and the other subjects, the ULA people required more time to correctly respond to the simultaneous haptic feedback slip signals, suggesting a higher cognitive load required by the ULA people. Conclusion ULA people can integrate multiple channels of simultaneously activated and nuanced haptic feedback with their control of individual fingers of an artificial hand. These findings provide a step toward empowering amputees to multitask with dexterous prosthetic hands, which remains an ongoing challenge.
Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics
Authors: Xiao Nan , Yang Wenming , Wang Jin , Li Jiarong , Zhao Ruoxuan , Li Muzheng , Li Chi , Liu Kang , Li Yingxin , Chen Zhibo , Yin Chaoqun , Li Xingqi , Jiang Yun 
Published: March 2023

Abstract
Glioma is a type of tumour that starts in the glial cells of the brain or the spine. Since the 1800s, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrence and the underlying mechanism. Medical doctors remain stymied regarding tumour recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒ function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for glioma.
Academic self-efficacy mediates the relationship between Student teacher interaction and students university Academic achievement in Ethiopia
Authors: Gebresilase Bereket Merkine , Zhao Wei 
Published: March 2023

Abstract
The foundation of every societal growth and in emerging nations like Ethiopia in particular, is the quality of education. It should be remembered that good teachers and students are essential for high-quality education. The major goal of this study was to demonstrate the direct and indirect effects of student-teacher interaction and student academic self-efficacy on the academic achievement of Ethiopian university students and to develop the scale to Ethiopian culture. A sample of 313 students from seven colleges and three schools, including 192 male and 121 female, answered questionnaires to gauge their level of interaction with their teachers and their academic self-efficacy to carry out university learning activities. Academic achievement and students' academic self-efficacy were significantly correlated with reports of student interaction with their teacher. The academic achievement of university students in Ethiopia was also highly correlated with students' reports of their academic self-efficacy. In addition, University students' academic self-efficacy played a partial mediating role in the association between student teacher interactions and academic achievement. According to the study's findings, student teacher interaction and academic self-efficacy are major determinants of academic success in universities. Limitations and the useful contributions of this study were discussed.
Graph Neural Network-Based Knowledge Graph Embedding for Personalized Recommendation Systems
Authors: Almeida  , Miranda Enzo , Ferreira Bruna , Teixeira Gael 
Published: March 2023

Abstract
With the increase in online content, recommendation systems have become an important tool to filter information overload and provide users with personalized experiences. Collaborative filtering is a classical recommendation technique that represents users and items as vectors. However, recent studies have shown that item attributes, represented as a Knowledge Graph (KG), can provide rich auxiliary information for recommendation systems. This paper proposes a Graph Neural Network (GNN) based on KGs to improve the accuracy, diversity, and interpretability of recommendation systems. The GNN fuses semantic related information in KG to achieve user as well as item representation habits. Neighboring nodes have different weights, which can be aggregated to obtain a more accurate representation of the current entity and improve the accuracy of recommendations. The learning process can be extended to more contents related to user interests, which can improve the diversity of recommendations. This paper proposes a graph neural network based on knowledge graphs, fusing semantic related information in KG to achieve user as well as item representation habits. Neighboring nodes have different weights, which can be aggregated to obtain a more accurate representation of the current entity and improve the accuracy of recommendations. Due to the influence of user preferences, the learning process can be extended to more contents related to user interests, which can improve the diversity of recommendations.
Local excision versus thrombectomy in thrombosed external hemorrhoids: A multicenter, prospective, observational study
Authors: Yalcinkaya Ali , Yalcinkaya Ahmet , Atici Semra Demirli , Sahin Can , Leventoglu Sezai 
Published: March 2023

Abstract
Background
Available guidelines describing the procedural treatment of thrombosed external hemorrhoids (TEH) rely solely on expert opinion. We aimed to compare local excision (LE) and thrombectomy (incision) in terms of treatment success, factors affecting success, and outcomes.
Methods
This was a multicenter, prospective, observational study conducted in eight centers from September 2020 to September 2021. A total of 96 patients (58 LE, 38 thrombectomy) were included. Risk factors, demographics and clinical characteristics were recorded. Follow-up studies were scheduled for the 1st week, 1st, 3rd and 6th months. Surgical success was assessed at 1 month. Hemorrhoidal Disease Symptom Score (HDSS) and Short Health Scale (SHS) were applied at baseline and the 6th month. Wexner fecal incontinence score was applied at all follow-up studies.
Results
Overall mean age was 41.5 ± 12.7 years. At baseline, groups were similar with regard to demographics and disease severity (HDSS) (p > 0.05 for all). Success was relatively higher in the thrombectomy group (86.8%) compared to the LE group (67.2%) (p = 0.054). Constipation and travel history were significantly associated with lower likelihood of LE success. Symptoms during follow-up were similarly distributed in the groups. Both methods yielded significant improvements in HDSS, SHS and Wexner scores; however, SHS scores (6 months) and Wexner scores (all time points) were significantly better in the thrombectomy group.
Conclusion
The in-office thrombectomy procedure may have better short-term outcomes compared to LE in terms of relative success, recurrence and quality of life. LE may yield particularly worse results in patients with constipation and travel history; thus, thrombectomy appears to be especially advantageous in these patient subsets.
Modern Lexicographic Interpretation of Psychic Vocabulary: A Standard Explanatory Dictionary
Authors: Zamanova I. V. 
Published: March 2023

This article describes the lexicography of psychic vocabulary in a diachronic aspect. For a long time, synonymic chains were the most common way of its interpretation, examples being a more recent lexicographic invention. However, both methods are concept-oriented. Unfortunately, neither of them solved the problems of a dictionary aimed at intercultural relations. The current globalization and informatization triggered non-traditional interpretations that describe not the concept, but a prototypical situation, which is associated with it. This study introduces several principles of interpreting the psychic vocabulary. These principles relate to the language, semantics, parameters, and structure of the semanteme. The approach is based on the connection between language and perception. For instance, the psychic vocabulary encodes the reaction of the heart as an organ ( love, rage, serenity, peace, disgust ). Therefore, the psychic vocabulary is different from the abstract vocabulary (good, evil, justice, democracy ), which does not encode bodily reactions. The author believes that the seme ‘heart’ is implicitly present in the semantic structure of the psychic vocabulary. Scientific literature features the lexeme of heart in comparative, conceptual, and metaphorical aspects, but not as an implicit component. Thus, the denotative space of the psychic vocabulary is a complex cognitive construct structured as ‘assessment / reaction of the heart / desire’, represented by the archisemes of feelings, emotions, and states. Words united by these archisemes demonstrate different valency, word-building, and pragmatic properties. In terms of the structure of the psychic polysemy, feelings and traits have the potential to develop the meaning of states, and words that denote physiological states generate figurative meanings of mental states.
Current Perspectives on Nanoparticle-based Targeted Drug Delivery
Approaches in Breast Cancer Treatment
Authors: Pandey Pratibha , Khan Fahad , Maqsood Ramish , Upadhyay Tarun Kumar 
Published: March 2023

Abstract:
Breast cancer is avertible yet one of the most widespread carcinomas globally. Though periodic screening and monitoring have resulted in reduced incidences, the malignancy claims in-creased death rates across the globe. Due to the non-specific and aggressive nature of available conventional cancer therapeutics, there is a crucial need for better treatment paradigms. Recent advancements in nanotechnology have aided in this by utilizing nanocarriers in targeted drug de-livery approaches. Optimized nanoparticles have been used to enhance the circulation time and target the efficacy of conventional therapeutic drugs. Passive targeting comprises surface modula-tion to avoid drug elimination via a standard body defense system. Active targeting includes chem-ical interaction with various genes, receptors, and antigens overexpressed during cancer progres-sion. Therefore, the present review recapitulates drug delivery approaches and nanoparticle-based targeting that can potentially overcome the limitations of conventional drug therapies.
Effect of SARS CoV-2 Infection on Periodontal Tissue: A Systematic Review
Authors: Karyadi Edi , Bouty Aulia Azizah Vidya , Mutalazimah M. 
Published: March 2023

Background:
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection in human respiratory cells. The first spread of this disease first occurred in Wuhan, China, in December 2019, and on March 11, 2020, the World Health Organization declared the spread of the infection as a global pandemic. People who are infected experience mild to moderate clinical symptoms which are characterized by an increase in T cell, CD8, and IgM/IgG levels. The occurrence of severe clinical symptoms reflects an excessive and uncontrolled increase in the secretion of pro-inflammatory cytokines, which impacts the systemic condition and periodontal tissues of affected patients.

Objective:
The aim of this study is to describe the impact of SARS CoV-2 infection on periodontal tissues.

Methods:
In this study, we searched the NCBI, PubMed, Google Scholar, and Research Gate databases. The keywords used were “coronavirus disease” or “COVID-19” or “SARS-CoV-2” with “oral manifestations” and “periodontal,” and we screened the articles using the PRISMA flow diagram.

Results:
Patients with COVID-19 present with a variety of systemic symptoms, as well as manifestations in the periodontal tissues, especially in the gingival area.

Conclusion:
SARS CoV-2 infection can impact periodontal tissues in the form of necrotizing ulcerative gingivitis, aphthous stomatitis, gingival hyperpigmentation, edema and erythema, lichen planus, and aphthous-like ulcers.
Religiosity or Income? Factors Driving Customer Buying Interest in Islamic Insurance Products
Authors: Nurohman Dede 
Published: March 2023

Despite the enormous potential represented by an 87% Muslim population and the growing welfare of the Muslim community in Indonesia, Islamic insurance has not grown rapidly during the past decades. The primary issues that hinder the growth of the Islamic insurance sector are thought to be people's level of income and religiosity. Therefore, this paper attempts to investigate the effect of religiosity and income on people's interest in buying Islamic insurance products. This study employed a quantitative approach with a questionnaire as a data mining technique. 200 residents of eight districts and cities in East Java, a province in Indonesia, participated as respondents in this study. The data analysis involved descriptive analysis, inferential analysis, classical assumption test, and hypothesis test. This study demonstrates that people's interest in buying Islamic insurance products is positively and significantly influenced by their religiosity and income, either partially or simultaneously. This result can be taken into account by the Islamic insurance sector when planning the best marketing plan, especially for the wealthy and fervently religious Muslim segment of society.
Impact of climate change on water sources and river-floodplain mixing in the natural wetland floodplain of Biebrza River
Authors: Berezowski Tomasz , Partington Daniel 
Published: March 2023

The origins of river and floodplain waters (groundwater, rainfall,
and snowmelt) and their extent during overbank flow events strongly
impact ecological processes such as denitrification and vegetation
development. However, the long-term sensitivity of floodplain water
signatures to climate change remains elusive. We examined how the
integrated hydrological model HydroGeoSphere and the Hydraulic
Mixing-Cell
method could help us understand the long-term impact of climate change
on water signatures and their spatial distribution in the protected
Biebrza River Catchment in northeastern Poland. Our model relied on
20th century Reanalysis Data from 1881 to 2015 and an ensemble of
EURO-CORDEX simulations for RCP 2.6, 4.5, and 8.5 from 2006 to 2099.
The historical component of the simulations was subjected to extensive
multiple-variable validation from 1881 to 2019. The results show that
the extents of water sources were rather stable in the floodplain
in the 1881-2015 period. The projected future impacts were variable
with each analyzed RCP, but in all cases, different significant trends
were present for the spatial distribution of water sources and for
the river-floodplain mixing. However, the total volume of water from
different sources was less sensitive to climate change than the dominant
sources and spatial distribution of water. The simulation results
highlight the impact of climate change on the extent of water sources
in temperate zone wetlands with significant implications for ecological
processes and management. These results also underscore the urgent
need to leverage such modeling studies to inform protective and
preservation
strategies of floodplain wetlands.