bluuebunny/crossref_metadata_2025_split huggingface dataset:
An energy‐based approach for uniaxial fatigue life estimation under asymmetric cyclic loading
Authors: Xiang Dong , Shen Yinhua , Sun Xinyu 
Published: March 2023

AbstractEnergy parameter formed by multiplying the maximum strain range and the peak stress has the problem that one value may correspond to multiple fatigue damage states. For this issue, a new energy parameter suitable for tension–compression is proposed, which includes an improved strain‐energy model and a strain‐energy ratio. The improved strain‐energy model deduced by judging the volume change of the micro‐element has positive and negative function which can use to distinguish tensile and compressive deformation. The strain‐energy ratio is established to characterize the alternate tensile and compressive deformation under asymmetric cyclic loading. Then, applying fatigue test data, a modeling approach for fatigue life estimation based on the strain‐energy ratio is proposed, and three example models are also exhibited. Finally, according to the example model, the case of a cantilever beam under asymmetric cycle loading is carried out. The results illustrate the feasibility of the improved energy parameter in characterizing tension–compression state and the applicability of the strain‐energy ratio‐based model in fatigue analysis.
Long‐term phytoplankton community dynamics in Lake Stechlin (north‐east Germany) under sudden and heavily accelerating eutrophication
Authors: Kröger Björn , Selmeczy Géza B. , Casper Peter , Soininen Janne , Padisák Judit 
Published: March 2023

Abstract

Climate warming and legacy phosphorus (P) in sediments are two main factors counteracting current efforts to prevent eutrophication of temperate freshwater lakes and reservoirs. Climate warming impacts lacustrine thermal regimes, accelerates harmful cyanobacterial growth, and increases the probability of periodic anoxic bottom conditions. Legacy P in sediments becomes influential over eutrophication because of its reactivation under anoxic conditions.

Lake Stechlin is a deep glacial lake of the Baltic Lake area, Germany in which artificial external P loading has been effectively blocked for more than 3 decades. The lakes trophic status was oligotrophic, until roughly 2 decades ago when it accelerated toward higher trophic levels. Here we analyse the temporal dynamics of Lake Stechlin phytoplankton biomass and composition in relation to chemical and hydrological covariates, based on monitoring data from 1994 to 2019 at sampling frequency of c. 27 samples per year.

Our results show an assemblage change toward cyanobacterial dominance that took place at several temporal scales. Intra‐annual compositional change became more pronounced over the study period, mainly because of changes during the autumn and winter seasons.

Results from a structural break point analysis of the phytoplankton time series with covariates, and from a hierarchical cluster analysis show that major changes occurred in 2007–2011. An analysis of early warning indicators did not unambiguously support this period as a critical transition. The change rather occurred as a rapid succession of major events during these years.

Results from convergent cross‐mapping causality tests are consistent with the hypothesis that increasing relative water column stability may drive eutrophication, and additionally, that the intra‐annual timing of the biomass change plays an important role in the lakes P loading.

Although quantitative data on internal P loading are unavailable, internal P mobilisation from sediments appears to be the most plausible mechanism behind the increased phytoplankton biomass. Lake Stechlin, therefore, is an example of the challenges that legacy P poses to the management of freshwater ecosystems in the context of climate warming, even when external P sources are effectively blocked, and local protective measures are in place.
Exploring the mediating role of utilitarian value and hedonic value in the formation of oppositional loyalty in online communities
Authors: Ma Xiangyang , Chen Han , Lang Xiaoping , Li Tieshan 
Published: March 2023

AbstractOur research expands the scope of the research on oppositional loyalty from brands to online communities. Online communities allow members to freely express their opinions and promote the occurrence of oppositional loyalty behaviours towards the communities. Oppositional loyalty is defined in this article that, for the purpose of strengthening the market position of their preferred community, members of the online community may express negative views or even show oppositional behaviour towards adversarial communities. In view of social capital theory, the study examines the effect of hedonic value and utilitarian value on oppositional loyalty in online communities. The results show that only hedonic value significantly affects oppositional loyalty; hedonic value mediates the effect of the three dimensions of social capital (network ties, identification, and common language) on oppositional loyalty. The study identifies that community type moderates the impact of social capital (identification and common language) on hedonic value but does not moderate the effect of social capital on utilitarian value. Finally, we find that members' oppositional loyalty towards their community can promote their community participation. This research provides recommendations for online community managers to manage and benefit from members' oppositional loyalty.
Reversing the Gaze: Can the EU Import Democracy from Others?
Authors: Nicolaidis Kalypso , Youngs Richard 
Published: March 2023

AbstractFor over two decades, the EU has used a wide range of policy instruments to support democratic reform in third countries under the assumption that the rest of the world must learn from Europeans. This one‐way democracy policy is out of tune with the times as political malaise spreads within the EU and as global geopolitics calls for genuine decolonial mindsets. In this contribution, we ask what it would take for the EU to reverse the democratic gaze. We argue that the EU could do more to open itself to the democratic innovations unfolding around the world where reformers have long been grappling with anti‐democratic playbooks. We distinguish between three relevant realms, namely, that of power‐sharing arrangements, democratic backsliding and regional mechanisms. We hope to offer a significant tweak to decolonization analysis and a political, normative supplement to this Special Issue's concern with outside influences on the EU.
Risk of uveitis in patients with psoriasis in Korea: A nationwide population‐based cohort study
Authors: Kim Bo Ri , Choi Seung Woo , Choi Chong Won , Lee Kun Hee , Kim Min Jae , Woo Se Joon , Youn Sang Woong 
Published: March 2023

AbstractBackgroundEvidence for the association between psoriasis and uveitis according to the severity of psoriasis including psoriatic arthritis (PsA) and type of uveitis is lacking, and there are no data on the frequency or timing of recurrence of uveitis in patients with psoriasis.ObjectivesWe aimed to evaluate the risk of first occurrence and recurrence of uveitis in patients with psoriasis in the Korean population. We further evaluated the risk of uveitis according to the severity of psoriasis, comorbidity of PsA and location of uveitis.MethodsIn a nationwide retrospective cohort study, we compared 317,940 adult patients who had psoriasis with 635,880 matched controls. Incidence rates (IRs) and estimated IR ratios of the first occurrence and recurrence of uveitis were calculated using survival analysis and Poisson regression, respectively.ResultsThe rate of uveitis incidence and uveitis recurrence in patients with psoriasis was 1.18 and 2.31 per 1000 person‐years, respectively. Compared to the controls, the IR ratios of development and recurrence of uveitis in patients with psoriasis were 1.14 (95% CI 1.08, 1.2) and 1.16 (95% CI 1.12, 1.21), respectively. The recurrence rate of uveitis was highest within 3 years after the onset of psoriasis. The corresponding IR ratios for uveitis recurrence in patients with mild psoriasis, severe psoriasis and PsA were 1.11 (1.06, 1.16), 1.24 (1.16, 1.33) and 1.49 (1.31, 1.7), respectively. Patients with psoriasis had an increased risk of recurrence of anterior uveitis, and patients with both psoriasis and PsA had an increased risk of recurrence of both anterior‐uveitis and panuveitis.ConclusionsPatients with psoriasis had a higher risk of both development and recurrence of uveitis, especially with severe psoriasis and PsA. The timing of uveitis recurrence was related to the onset of psoriasis, and patients who had psoriasis with PsA had an increased risk of vision‐threatening panuveitis.
The classical and alternative circulating renin‐angiotensin system in normal dogs and dogs with stageB1andB2myxomatous mitral valve disease
Authors: Hammond Hillary H. , Ames Marisa K. , Domenig Oliver , Scansen Brian A. , Yang Nuen Tsang , Wilson Machelle D. , Sunshine Erin , Brunk Kaitlyn , Masters Allison 
Published: March 2023

AbstractBackgroundThe behavior of the comprehensive circulating renin‐angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before to the onset of congestive heart failure remains largely unexplored.Hypothesis/ObjectivesThe classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.AnimalsOne‐hundred seventeen client‐owned dogs (normal = 60; B1 = 31; B2 = 26).MethodsProspective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE, ACE2) and renin activity surrogates were calculated from AP concentrations. Equilibrium dialysis (ED) and immediate protease inhibition (PI) methods of AP quantification were compared in 14 healthy dogs.ResultsCore RAS activity and aldosterone concentrations did not differ among the 3 groups. However, the balance between the alternative and classical RAS differed, with dogs with stage B2 MMVD having significantly higher ACE2 activity surrogate (ACE2surr) when compared to normal dogs (adjustedP = .02; ratio of medians for ACE2surr[B2:normal], 1.89; 95% confidence interval [CI]: 1.4‐2.6). The ED and PI methods of AP quantification were highly correlated (AngI,r = .9,P < .0001; AngII,r = .8,P = .001).Conclusions and Clinical ImportanceCirculating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.
The Ries impact and its distal effects in sediments of Central Europe—A review
Authors: Lange Jan‐Michael , Suhr Peter 
Published: March 2023

AbstractThe Ries impact is the most important cosmic event in the younger geological history of Europe. Its effects reach far beyond the area considered so far and are documented in manifold evidence. In this paper, the widely scattered reports in the literature are compiled and supported with investigations by the authors. Besides well‐known ejecta features like the Brockhorizont, Reuter's blocks, and moldavites, little known or forgotten indications, like a lechatelierite and β‐cristobalite occurrence in Bavaria and unusual sedimentation phenomena in northern Germany, are presented. The paleogeographic reconstruction shows that the Ries impact occurred on the southern side of the Neogene Central European mainland. Large parts of this erosional area were devastated by the impact. Pressure waves and thermal radiation had a lasting effect on the landscape within hundreds of kilometers around the impact site. Destruction of the vegetation cover by impact‐induced storms, wildfires, and heavy rainfall generated intense erosion. The adjacent sedimentation area to the north (Paleo‐North Sea) experienced an increased and short‐term supply of terrestrial debris to the marine environment. The stratigraphic coincidence of these exceptional sediments with the Ries event leads us to conclude that the distal effects of the impact are present here, which have so far received little or no attention in this context. The paper considers the different indications and sets them in a large‐scale context.
Impact of the COVID‐19 pandemic on infant feeding practices in the United States: Food insecurity, supply shortages and deleterious formula‐feeding practices
Authors: Marino Jessica A. , Meraz Kimberly , Dhaliwal Manuvir , Payán Denise D. , Wright Tashelle , Hahn‐Holbrook Jennifer 
Published: March 2023

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic increased food insecurity among US households, however, little is known about how infants, who rely primarily on human milk and/or infant formula, were impacted. We conducted an online survey with US caregivers of infants under 2 years of age (N = 319) to assess how the COVID‐19 pandemic impacted breastfeeding, formula‐feeding and household ability to obtain infant‐feeding supplies and lactation support (68% mothers; 66% White; 8% living in poverty). We found that 31% of families who used infant formula indicated that they experienced various challenges in obtaining infant formula, citing the following top three reasons: the formula was sold out (20%), they had to travel to multiple stores (21%) or formula was too expensive (8%). In response, 33% of families who used formula reported resorting to deleterious formula‐feeding practices such as diluting formula with extra water (11%) or cereal (10%), preparing smaller bottles (8%) or saving leftover mixed bottles for later (11%). Of the families who fed infants human milk, 53% reported feeding changes directly as a result of the pandemic, for example, 46% increased their provisioning of human milk due to perceived benefits for the infant's immune system (37%), ability to work remotely/stay home (31%), concerns about money (9%) or formula shortages (8%). Fifteen percent of families who fed human milk reported that they did not receive the lactation support they needed and 4.8% stopped breastfeeding. To protect infant food and nutrition security, our results underscore the need for policies to support breastfeeding and ensure equitable and reliable access to infant formula.
Weight loss breaks the bond between nonalcoholic fatty liver disease and cardiovascular diseases: A clinical and epidemiological perspective
Authors: Ala Moein , Eftekhar Seyed Parsa 
Published: March 2023

SummaryNonalcoholic fatty liver disease (NAFLD) is a growing health concern that is closely related to obesity and metabolic syndrome. In particular, NAFLD has been increasingly reported in adolescents and young adults in recent years. Cardiovascular diseases (CVDs) such as cardiac remodeling, heart failure, myocardial infarction, valvular heart diseases, and arrhythmia are more common in patients with NAFLD. CVD are the major cause of mortality in NAFLD. Although NAFLD often affects patients with obesity/overweight, it can also affect subjects with normal body mass index (BMI), known as lean NAFLD, which has a strong correlation with CVD. Obesity imposes a considerably increased risk of NAFLD and CVD. Consistently, weight‐lowering approaches that can pronouncedly decrease body weight and maintain it in the long term, such as bariatric surgery and treatment with semaglutide and tirzepatide, have been promising in alleviating both CVD and NAFLD. Interestingly, compared with patients with NAFLD and obesity, a minimal amount of weight loss resolves NAFLD in lean patients. Besides the widespread use of bariatric surgery, the development of new GLP‐1 agonists and GLP‐1 GIP agonists revolutionized the treatment of obesity in recent years. Here, we discuss the interwoven correlation between obesity, NAFLD, and CVD and the benefits of weight‐lowering approaches.
Small noncoding RNA in Streptococci: From regulatory functions to drug development
Authors: Yang Yang , Wang Liu , Liu Liu , Zou Jian , Huang Dingming , Li Yuqing 
Published: March 2023

AbstractStreptococci are a genus of gram‐positive coccus of spherical bacteria, including many commensal bacteria and opportunistic pathogens that threaten the public health system. Small noncoding RNAs (sRNAs) are a class of noncoding RNAs regulating gene expression via various regulatory mechanisms, which have been illustrated to play vital roles in regulations of virulence factor expressions. Recent advances in sequencing technology and bioinformatic analysis facilitated discovery of a myriad of sRNAs from pathogenic bacteria, revealing a variety of unique features that contribute to gene expressions and virulence regulations. Although various research studies have reported the regulatory functions of sRNAs in the virulence of bacterial species of the genus Streptococci, the common features of sRNAs in the pathogenesis of Streptococci remain unclear. This blocks the development of novel antistreptococcal antibiotics and antibacterial strategies. Here, we summarize the fundamental roles of Streptococcal sRNAs in pathogenic regulations, which advance mechanistic understanding of streptococcal infection associated diseases. Moreover, we discuss the prospects of sRNA acting as drug targets to combat bacterial antibiotic resistance.
Non‐habit‐associated squamous cell carcinoma of the tongue in a treated breast cancer patient
Authors: Mahindre Swapnagandha , Sarode Gargi S. , Sengupta Namrata , Anand Rahul , Sarode Sachin C. 
Published: March 2023

AbstractThe development of second cancer following a primary cancer is an enigma for oncologists. A very few cases have been reported in the literature, wherein, a second malignancy developed following the treatment protocols of the first cancer. We report a case of a breast cancer patient who later developed oral squamous cell carcinoma of the tongue and discuss the possible etiologies of such unfavorable consequences.
Outcomes of transvenous lead extraction in octogenarians using bidirectional rotational mechanical sheaths
Authors: Migliore Federico , Pittorru Raimondo , Dall'Aglio Pietro Bernardo , De Lazzari Manuel , Falzone Pasquale Valerio , Sottini Simone , Dentico Alessia , Ferrieri Alessandra , Pradegan Nicola , Bertaglia Emanuele , Iliceto Sabino , Gerosa Gino , Tarzia Vincenzo , Carretta Domenico 
Published: March 2023

AbstractBackgroundOutcomes of transvenous lead extraction (TLE) are well reported in the general population, However, data on safety, efficacy of TLE in octogenarians with a long lead dwell time, using powered extraction tools are limited. The aim of this multicenter study was to evaluate the safety, effectiveness of TLE in octogenarians using the bidirectional rotational mechanical sheaths and mid‐term outcome after TLE.MethodsThe study population comprised 83 patients (78.3% male; mean age 85 ± 3 years; [range 80–94 years]) with 181 target leads. All the leads (mean implant duration 112 ± 77 months [range 12–377]) were extracted exclusively using the Evolution RL sheaths (Cook Medical, Bloomington, IN, USA).ResultsThe main indication for TLE was infection in 84.3% of cases. Complete procedural success rate, clinical success rate, per lead were 93.9% and 98.3%, respectively. Failure of lead extraction was seen in 1.7% of leads. The additional use of a snare was required in 8.4% of patients. Major complications occurred in one patient (1.2%). Thirty‐day mortality after TLE was 6%. During a mean time follow‐up of 22 ± 21 months, 24 patients (29%) died. No procedure‐related mortality occurred. Predictors of mortality included ischemic cardiomyopathy (HR 4.35; 95% CI 1.87–10.13; p = .001), left ventricularejection fraction ≤35% (HR 7.89; 95% CI 3.20–19.48; p < .001), and TLE for systemic infection (HR 4.24; 95% CI 1.69–10.66; p = .002).ConclusionsAt experienced centers bidirectional rotational mechanical sheaths combined with different mechanical tools and femoral approach allowreasonable success and safety in octogenarian with long lead dwell time. Patient's age should not influence the decision to extract or not the leads, although the 30‐day and mid‐term mortality are significant, especially in the present of specific comorbidities.
N6‐methyladenosine RNA modification regulates cotton drought response in a Ca2+ and ABA‐dependent manner
Authors: Li Baoqi , Zhang Mengmeng , Sun Weinan , Yue Dandan , Ma Yizan , Zhang Boyang , Duan Lingfeng , Wang Maojun , Lindsey Keith , Nie Xinhui , Zhang Xianlong , Yang Xiyan 
Published: March 2023

SummaryN6‐methyladenosine (m6A) is the most prevalent internal modification present in mRNAs, and is considered to participate in a range of developmental and biological processes. Drought response is highly regulated at the genomic, transcriptional and post‐transcriptional levels. However, the biological function and regulatory mechanism of m6A modification in the drought stress response is still poorly understood. We generated a transcriptome‐wide m6A map using drought‐resistant and drought‐sensitive varieties of cotton under different water deficient conditions to uncover patterns of m6A methylation in cotton response to drought stress. The results reveal that m6A represents a common modification and exhibit dramatic changes in distribution during drought stress. More 5'UTR m6A was deposited in the drought‐resistant variety and was associated with a positive effect on drought resistance by regulating mRNA abundance. Interestingly, we observed that increased m6A abundance was associated with increased mRNA abundance under drought, contributing to drought resistance, and vice versa. The demethylase GhALKBH10B was found to decrease m6A levels, facilitating the mRNA decay of ABA signal‐related genes (GhZEP, GhNCED4 and GhPP2CA) and Ca2+ signal‐related genes (GhECA1, GhCNGC4, GhANN1 and GhCML13), and mutation of GhALKBH10B enhanced drought resistance at seedling stage in cotton. Virus‐induced gene silencing (VIGS) of two Ca2+‐related genes, GhECA1 and GhCNGC4, reduced drought resistance with the decreased m6A enrichment on silenced genes in cotton. Collectively, we reveal a novel mechanism of post‐transcriptional modification involved in affecting drought response in cotton, by mediating m6A methylation on targeted transcripts in the ABA and Ca2+ signalling transduction pathways.