bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zoning and Optimization Strategies of Land Spatial Ecological Restoration in Liangjiang New Area of Chongqing Based on the Supply-Demand Relationship of Ecosystem Services
Authors: Hu Miaofen , Yan Shuiyu , Zhang Hongrui , Tang Jun 
Published: April 2023

Abstract
An ecological land restoration is necessary to develop a comprehensive land consolidation plan. Scientific ecological restoration zoning is crucial to the development of differentiated restoration strategies as well as to the improvement of quality during construction. This study used a series of methods such as the InVEST model, spatial autocorrelation, and coupling coordination degree models using Liangjiang New Area as an example to quantifiably quantify both regional ecosystem services supply and demand at the county and district levels. Determine the land's spatial ecological restoration zones and present the optimization strategies based on the supply-demand matching and coordination relationship. The results revealed that: (1) A considerable difference was identified between the supply and demand of ecosystem services in the Liangjiang New Area of Chongqing, with "high in the northeast and low in the southwest" spatial patterns for supply and "high in the southwest and low in the northeast" spatial patterns for demand. (2) The supply-demand matching relationship of ecosystem services in the Liangjiang New Area of Chongqing was characterized by spatial mismatches of high supply and low demand and low supply and high demand, with an average coordination degree index of 0.2, indicating uncoordinated supply and demand. (3) Based on the supply-demand relationship of ecosystem services, the regional ecological base, and the functional orientation of upper planning, the Liangjiang New Area was divided into four zones: high supply-low demand, low supply-high demand, and high supply-high demand zones, for which the respective optimization strategies were presented.
Old hemorrhage with cystic degeneration of hepatic cavernous hemangioma: A case report
Authors: Zhou Wen , Nie Han-qiu , Zhang Fang-fang , Zhou Xian-fei 
Published: April 2023

Abstract
Background:Hepatic cavernous hemangioma is the most common benign tumor of the liver, but spontaneous intratumoral hemorrhage of the tumor is clinically rare, and cystic degeneration caused by old hemorrhage is even rarer. Hepatic cavernous hemangioma can usually be confirmed by imaging, but old hemorrhage with cystic degeneration, as a unique imaging presentation, cannot be confirmed preoperatively. Therefore, hepatic cavernous hemangioma can easily be misdiagnosed as cystic adenoma or malignant tumor of the liver.
Case presentation: A 66-year-old man was admitted to hospital with right upper abdominal distention and pain for 3 days caused by a mass in the right lobe of the liver that had been present for >10 years. Preoperative routine blood tests showed no abnormalities. Abdominal enhanced computed tomography showed a large, roughly circular lesion in the seventh segment of the liver, with clear borders and circumferential, ring-like high-density shadowing with no abnormal enhanced shadowing (~44 mm in diameter) after dynamic enhancement. The patient underwent surgery because of the possibility of malignancy. The postoperative specimen was pathologically confirmed as an old hemorrhage with cystic degeneration of hepatic cavernous hemangioma.
Conclusion: The imaging presentation of this lesion may help in the diagnosis of atypical intratumoral hemorrhage of hepatic cavernous hemangioma.
Void content of PP/CF Wet-laid Nonwoven Composites: Effect of Fiber Content and Molding Conditions, and Void Elimination Mechanism
Authors: Yan Xin 
Published: April 2023

AbstractVarious wet-laid nonwoven composites have been well-developed in recent decades. However, studies that systematically investigate the factors affecting the void content of wet-laid nonwoven composites are still missing. This paper aims to study the factors affecting the void content of wet-laid nonwoven composites and propose a mechanism for void elimination in wet-laid nonwoven composites. Polypropene (PP) and carbon fiber (CF) were chosen to manufacture PP/CF wet-laid nonwoven composites. An orthogonal experimental design found that the CF content and molding pressure can dominate the void content while molding temperature and time have non-significant effects. Subsequently, this paper proposed that the void elimination mechanism is the compression of impregnated CF network (compression mechanism) instead of the matrix’s infiltration to the dry CF network (infiltration mechanism). In order to validate the compression mechanism, the compression curve of the dry CF network was transformed into curves predicting the void content of the PP/CF nonwoven composites. Comparing the predicted and experimental void content suggests that void elimination follows the compression mechanism.
Exploring Mechanism of Actions for Eugenol and Beta- Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
Authors: Trivedi Krupali , Rathaur Pooja , Parmar Nilam , Pancholi Suraj , Gelat Brijesh , Chettiar Shiva , Patel Alpesh , Jhala Devendrasinh 
Published: April 2023

Abstract
Background: Major deaths due to colorectal cancer (CRC) arise from the metastatic dissemination of primary tumors, which is related to molecules contributing to metastatic phenotype, the pathways they control, and the genes they regulate.
Purpose: To evaluate the effect of eugenol (EUG) and beta-caryophyllene (BCP) in combination with 5-fluorouracil in-vitro cytotoxic activity and in-silico method.
Methods: We tested the compounds on human colorectal cancer cell line HCT116 for the combined effect of 5-FU with EUG and BCP in in-vitro MTT assay. The pharmacokinetic assessment was carried out through in-silico ADMET analysis. Compound-Disease-Target (C-D-T) network were constructed against metastatic Colorectal cancer (mCRC) from which the hub proteins were selected for molecular docking studies. Enrichment analysis for the key targets was explored for gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways involved in mCRC to explore their functional role in human body for EUG, BCP and 5-FU.
Results: ADMET analysis showed that both the compounds follow the rule of five with good bioavailability thus, the compounds were found to be in the acceptable range by following drug-likeness properties. MTT assay revealed in-vitrocytotoxic effects of all three compounds and a significant reduction in IC50 values (p < 0.05) when treated the cells in combination thereby giving synergistic effects (CI < 1) represented by the Fa-CI plot. C-D-T network showed that EUG, BCP, and 5-FU target 58, 24, and 49 proteins of metastatic CRC, out of which 11 target proteins were intersected in the Venn diagram. The merged C-D-T network of these three compounds showed 84 target proteins of CRC from which 16 were selected based on their edge count which includes HSP90AA1, IGF-1R, ESR1, and CASP3. These were further screened in molecular docking which depicted that EUG, BCP, and 5-FU inhibited the C-D-T network’s core target protein HSP90AA1 (Heat shock protein-90 alpha) more effectively than any other proteins.
Conclusion: Our data revealed multitarget strategy to increase the effectiveness of the drug 5-FU by reducing its dosage when combined with natural phytocomponents EUG and BCP. Here, the synergism also proved effective against mCRC.
Efficacy and safety of axillary vein puncture real-time guided by roadmap fluoroscopy in cardiac pacemaker implantation
Authors: Chen Qiying , Wu Bangwei , Zhu Zhidong , Li Junping , Jin Bo 
Published: April 2023

Abstract
Objective
Roadmap fluoroscopy has never previously been evaluated for axillary vein puncture in clinical practice. Our retrospective cohort study was performed to investigate the efficacy and safety of axillary vein puncture real-time guided by roadmap fluoroscopy in cardiac pacemaker implantation.
Methods and Results
A total of 178 patients undergoing axillary vein puncture in permanent pacemaker implantation were included in the present cohort study during a 1-year period at our institution. All procedures were performed by the operators with previous experience in axillary approach. Primary endpoint was defined as axillary vein success rate. Secondary endpoints were venous access site change, time to obtain venous access, procedural time, and complication rate. For the primary outcomes, a higher success rate was observed in the roadmap group compared with the blind puncture group (95.2% vs 78.7%; P < 0.001), as well as a lower rate of venous access site change (7.1% vs 35.1%; P < 0.001) and shorter time to obtain venous access and procedural time, with lower complications (3.6% vs 6.4%; P < 0.01).
Conclusion
The roadmap fluoroscopy real-time guided axillary venous access is safer and has a better success rate and faster execution time compared with the blind axillary puncture in cardiac pacemaker implantation. However, further larger scale prospective randomized controlled trials are required to confirm the findings.
What is the impact of thyroid cancer history on in vitro fertilization: A cohort study
Authors: Lu Jinyu , Xiong Mimi , Ouyang Nengyong , Wu Ruochun , Du Fengjiao , Li Ruiqi , Wang Wenjun 
Published: April 2023

Abstract
Background
The incidence of thyroid cancer is increasing every year. Surgical resection is one of the main treatments for thyroid cancer, but it can affect thyroid function. In women of childbearing age, thyroid dysfunction is associated with infertility. The aim of this study was to investigate the changes in fertility and the risk of adverse outcomes in women with thyroid cancer (post-thyroidectomy) combined with infertility.
Methods
This retrospective cohort study included 17086 in vitro fertilization (IVF) cycles from January 2014 to March 2022 at the Sun Yat-Sen Memorial Hospital Reproductive Center, Sun Yat-Sen University. A 1:4 propensity score matching was used to match the thyroid cancer group with the control group. Categorical variables were tested with chi-square test and continuous variables with Kruskal test to analyze the differences in baseline characteristics, thyroid stimulating hormone (TSH), number of mature follicles, number of eggs gained, normal fertilization rate, quality embryo rate and pregnancy outcome between the two groups. Generalized estimating equation was used to investigate the effects of TSH on clinical pregnancy and live birth in the two groups.
Results
The thyroid cancer group had significantly lower TSH levels than the control group (median: 1.27 mIU/L vs. 1.58 mIU/L, P = 0.017). However, the number of retrieved oocytes, normal fertilization rate, good quality embryo rate, clinical pregnancy rate, and live birth rate were not significantly different between the two groups (P > 0.05). History of thyroid cancer and TSH have an interactive effect on live birth rate (RR: 2.280, 95%CI: 1.126, 4.616, P = 0.022), but not clinical pregnancy rate (P < 0.05).
Conclusions
Our study showed that IVF-ET outcomes in infertile women were not affected by the history of thyroid cancer (post-thyroidectomy), but the live birth rates were more affected by TSH level. The thyroid function of patients with a history of thyroid cancer should be checked regularly and remained at a normal range.
Trial registration
This study was approved by the Ethics Committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSKY-2022-082-01)
Clinical outcomes of Group D Retinoblastoma at a tertiary care hospital in Pakistan
Authors: Javed Khawaja Muhammad Ammar Ali , Vayani Usman , Javed Anum , Chatni Muhammad Hanif 
Published: April 2023

Abstract
Purpose
To retrospectively analyse globe salvage rates in group D retinoblastoma (RB) with currently available treatment options in Pakistan over a period of nine years.
Methods
A retrospective, cross-sectional analysis including all patients who presented with Group D RB according to the International Classification of Retinoblastoma (ICRB), from April 2013 to December 2022 at Patel Hospital, Karachi, Pakistan. Indirect ophthalmoscopy done under anaesthesia was used to visualise and evaluate tumour characteristics and clinical response to the treatment offered. Globe salvage was attempted with systemic chemotherapy, local consolidative therapy along with intravitreal melphalan. Survival analysis was performed using Kaplan-Meier curves on SPSS version 26.
Results
The mean age at diagnosis was 17.2 months.14 (93%) patients had bilateral disease and one (7%) had unilateral disease. Globe salvage was achieved in 11 out of 15 eyes (73.33%) in a mean follow up time of 57.5 weeks (range 7–263 weeks). All eyes received laser therapy, 5 required additional cryotherapy and 1 eye was given adjuvant intravitreal melphalan. 4 eyes underwent secondary enucleation. All eyes amongst this group received systemic chemotherapy, laser, cryotherapy and 3 eyes received intravitreal melphalan (4 cycles). Kaplan-Meier survival analysis showed an overall globe salvage rate of 93%, 76%, and 65% at 1, 2 and 3 years, respectively. No metastasis or deaths were reported.
Conclusion
Intravenous chemotherapy (IVC) coupled with local therapy remains an effective mode of treatment in select patients with Group D RB despite advancements in treatment modalities like intra-arterial chemotherapy. This is especially promising for developing countries with limited resources and socioeconomic barriers.
Identification of Biomarkers Associated with Diagnosis of Diabetic Nephropathy Patients Based on Bioinformatics and Machine Learning
Authors: Yin Guicao , Zheng Shengqi , Xie Zisong , Tian Haoyu , Hua Tianchi , Li Junhui , Tian Feng , Wang Xiaoxiang , Fan Qibing , Zhu Zhenpeng , Qi Lezhong , Li Yifan 
Published: April 2023

Abstract
Diabetic nephropathy (DN) is a common microvascular complication of diabetes, and early diagnosis is crucial for the prognosis of patients. The purpose of this study was to identify novel diagnostic biomarkers of DN and to analyze possible associations between key genes and infiltrating immune cells. Download the GSE1009, GSE30528, and GSE47183 datasets, including human DN and normal samples, from the GEO dataset. Differentially expressed genes (DEGs) were identified in 33 DN cases and 26 control cases. SVM-RFE analysis and LASSO regression model were used to screen for possible markers. The composition patterns of 22 immune cell components in DN were determined by using CIBERSORT technique. In this study, 57 genes were identified as significantly up-regulated and 80 genes as significantly down-regulated. Analysis of KEGG signaling pathway showed that complete and coalition cascades, PI3K-Akt signaling pathway, focal adhesion, RAP1 signaling pathway and age-rage signaling pathway were significantly enriched. Based on the results of machine learning, we identified C1orf21, TGFBI, ATF3, and BHMT as key diagnostic genes for DN, which were further confirmed by ROC analysis. Immunocyte infiltration analysis revealed four key diagnostic gene expressions associated with multiple immunocytes in DN. Overall, our findings may offer some new insights into the exploration of new markers for the diagnosis of DN. Key genes and their relationship with immune infiltration may provide new insights into the development of DN.
A new integrated strategy for high purity pinolenic acid production from Pinus koraiensis Sieb. et Zucc seed oil and evaluation of its hypolipidemic activity in vivo
Authors: Wu Xiaodan , Bao Sansan , Yu Liang , Wang Tao , Qin Bingyang , Shao Guansong , Wang Zihan , Fu Yujie 
Published: April 2023

Abstract
Pinolenic acid is a polyunsaturated fatty acid present only in Pinus koraiensis Sieb. et Zucc seed oil. It can inhibit and eliminate the adverse effects of other fatty acids on the body. In order to solve the structural instability problem of polyunsaturated fatty acids, pinolenic acid of P. koraiensis seed oil was effectively isolated and purified by the integrated strategy of ethyl esterification followed by urea inclusion for the first time. Under the optimal conditions after the Box-Benhnken Design experimental, ethyl pinolenate with high purity 94.95% could be obtained, and the average content of PNAEE can still reach 86.18%. Then ethyl pinolenate was characterized by Gas chromatography-mass spectrometry, Fourier transform infrared, and Nuclear magnetic resonance spectra, results showed that ethyl pinolenate was successfully prepared. In addition, the hypolipidemic activity of ethyl pinolenate had been tested in vivo and showed that ethyl pinolenate had obvious hypolipidemic activity. The new strategy for high purity ethyl pinolenate production from P. koraiensis seed oil possesses great potential in food healthy field in the future.
Evaluation of a 12-week app-guided exercise intervention in patients with knee osteoarthritis (re.flex): a study protocol for a randomized controlled trial.
Authors: Dieter Valerie , Martus Peter , Janssen Pia , Krauss Inga 
Published: April 2023

Abstract
Background

The current health care demonstrates an insufficient provision and utilization of physical exercises that are recommended as first-line treatment in clinical guidelines for patients with knee osteoarthritis. Mobile health (m-health) technologies offer new opportunities to guide and monitor home-based exercise programs by using mobile devices and inertial sensors in combination with a digital application (app). This study evaluates patients benefit using the specific digital health application re.flex for patients with knee osteoarthritis (OA).

Methods

This monocentric, two-arm, randomized controlled parallel-group trial evaluates the effectiveness of the app- and sensor-guided exercise program re.flex for patients with moderate to severe knee OA. We aim to recruit 200 participants via newspaper, newsletter and information events. Participants will be randomly allocated to the intervention group (IG) and the control group (C) in a 1:1 ratio. Participants of C do not receive any study intervention or instruction for any change to their previous health care utilization. IG comprises a 12-week home training program with three sessions per week in addition to regular care. Exercises are guided and monitored by use of the training app (re.flex) and two accelerometers that are attached proximally and distally to the affected knee joint. Pre- and post-measurements will take place at baseline (t0) and after 12 weeks (t1). Primary outcomes will be osteoarthritis-specific pain and physical function measured with the Knee Osteoarthritis Outcome Score (KOOS) subscales Pain and Function in daily living (ADL). Secondary, further self-reported health outcomes, a performance measurement, app logfiles and safety will be assessed.

Discussion

M-health interventions can be used independently from time and location and allow most patients to get access to this kind of exercise guidance. As such, re.flex can bridge part of the gap between recommendations for strengthening exercises in patients with knee OA and the insufficient actual care situation. This randomized controlled trial is designed to provide conclusions on the effectiveness of the health application re.flex for the population under study and will give further insight into adherence rates and the safety of its use.

Trial registration

The trial was registered on 20/01/2023 at www.drks.de (ID: DRKS00030932).
Influence of polishing after bleaching on color change, enamel surface morphology and sensitivity: a randomized clinical trial
Authors: Barros Antonia , Silva George , Alencar Cristiane , Kuga Milton , Araújo Jesuína , Silva Cecy 
Published: April 2023

Abstract
Objective

This trial evaluated the influence of polishing on enamel color change after in-office bleaching treatment. In addition, it evaluated the influence of polishing on tooth morphology and sensitivity.

Materials and methods

Fifty volunteers were randomized into two groups (n = 25): In-office bleaching with 35% hydrogen peroxide gel for 45 min without polishing (GSEM) or with polishing (GP). The color analysis was performed four times, at baseline, and immediately after the 1st, 2nd, and 3rd session of bleaching with Easyshade spectrophotometer (Vita-Zahnfabrik), using the CIELAB (ΔE) and CIEDE2000 (ΔE00) formulas, and whiteness index (ΔWID). A qualitative analysis of enamel morphology was performed using replicas obtained with epoxy resin observed in a scanning electron microscope (277× and 554× magnification). The tooth sensitivity was assessed daily using the visual analog scale (α = 0.05).

Results

There was no statistically significant difference (p > 0.05) in tooth color change when comparing ΔE, ΔE00, and ΔWID between groups. The enamel surface showed greater areas of irregularities and depressions in the GP group than in the GSEM group. There was no difference in tooth sensitivity (p > 0.05) between groups.

Conclusions

Polishing after in-office tooth whitening does not change the tooth color and sensitivity and promotes greater changes in enamel surface morphology.
Clinical relevance: Polishing immediately after tooth whitening causes greater changes in enamel surface morphology.
A parallel Canny edge detection algorithm based on OpenCL acceleration
Authors: Song Yupu , Li Cailin , Zhou Qinglei , Xiao Han 
Published: April 2023

Abstract
In the process of Canny edge detection, a large number of high complexity calculations such as Gaussian filtering, gradient calculation, non-maximum suppression, and double threshold judgment need to be performed on the image, which takes up a lot of operation time, which is a great challenge to the real-time requirements of the algorithm. In order to solve this problem, a fine-grained parallel Canny edge detection method is proposed, which is optimized from three aspects: task partition, vector memory access, and NDRange optimization, and CPU-GPU collaborative parallelism is realized. At the same time, the parallel Canny edge detection methods based on multi-core CPU and CUDA architecture are designed. The experimental results show that OpenCL accelerated Canny edge detection algorithm can achieve 20.68 times, 3.96 times, and 1.21 times speedup ratio compared with CPU serial algorithm, CPU multi-threaded parallel algorithm, and CUDA-based parallel algorithm, respectively. The effectiveness and performance portability of the proposed Canny edge detection parallel algorithm are verified, and it provides a reference for the research of fast calculation of image big data.