bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of online non‐rigid motion correction for high‐resolution supine breast MRI
Authors: Isaieva Karyna , Meullenet Camille , Vuissoz Pierre‐André , Fauvel Marc , Nohava Lena , Laistler Elmar , Zeroual Mohamed Aziz , Henrot Philippe , Felblinger Jacques , Odille Freddy 
Published: June 2023

AbstractPurposeConventional breast MRI is performed in the prone position with a dedicated coil. This allows high‐resolution images without breast motion, but the patient position is inconsistent with that of other breast imaging modalities or interventions. Supine breast MRI may be an interesting alternative, but respiratory motion becomes an issue. Motion correction methods have typically been performed offline, for instance, the corrected images were not directly accessible from the scanner console. In this work, we seek to show the feasibility of a fast, online, motion‐corrected reconstruction integrated into the clinical workflow.MethodsFully sampled T2‐weighted (T2w) and accelerated T1‐weighted (T1w) breast supine MR images were acquired during free‐breathing and were reconstructed using a non‐rigid motion correction technique (generalized reconstruction by inversion of coupled systems). Online reconstruction was implemented using a dedicated system combining the MR raw data and respiratory signals from an external motion sensor. Reconstruction parameters were optimized on a parallel computing platform, and image quality was assessed by objective metrics and by radiologist scoring.ResultsOnline reconstruction time was 2 to 2.5 min. The metrics and the scores related to the motion artifacts significantly improved for both T2w and T1w sequences. The overall quality of T2w images was approaching that of the prone images, whereas the quality of T1w images remained significantly lower.ConclusionThe proposed online algorithm allows a noticeable reduction of motion artifacts and an improvement of the diagnostic quality for supine breast imaging with a clinically acceptable reconstruction time. These findings serve as a starting point for further development aimed at improving the quality of T1w images.
A pooled subgroup analysis of glucarpidase treatment in 86 pediatric, adolescent, and young adult patients receiving high‐dose methotrexate therapy in open‐label trials
Authors: Janeway Katherine A. , Gros Luis , Schwartz Stefan , Daugherty Claire , Gallardo Eva , Hill Christon , Thomas Emma , Ward Suzanne , Rizzari Carmelo 
Published: June 2023

AbstractBackgroundDelayed methotrexate elimination can occur in patients undergoing high‐dose methotrexate cancer treatment. Effectiveness of glucarpidase for rapidly reducing methotrexate concentrations was shown in compassionate‐use trials in patients aged 0–84 years.MethodsWe performed post hoc analyses of infants (≥28 days to <2 years), children (≥2 to <12 years), adolescents (≥12 to <15 years), and young adults (≥15 to <25 years) from four multicenter, open‐label, single‐arm, glucarpidase compassionate‐use trials. Patients had toxic methotrexate levels due to delayed methotrexate elimination and/or renal dysfunction, and received glucarpidase (50 U/kg). The primary endpoint was clinically important reduction (CIR) in plasma methotrexate (methotrexate ≤1 μmol/L at all post‐glucarpidase measurements) based on high‐performance liquid chromatography.ResultsAmong 86 patients included in efficacy analyses, CIR was achieved by zero of one infant (0.0%), five of 16 children (31.3%), seven of 24 adolescents (29.2%), and 26/45 young adults (57.8%). Median methotrexate reduction was 98.7% or higher in each group 15 minutes post‐glucarpidase. Patients with pre‐glucarpidase methotrexate less than 50 μmol/L (35/42, 83.3%) were more likely to achieve CIR than those with methotrexate 50 μmol/L or higher (1/37, 2.7%). The most common treatment‐related adverse event was paresthesia, occurring in three adolescents (4.5%) and six young adults (5.2%). No other treatment‐related adverse event occurred in 5% or higher of any age group.ConclusionAfter accounting for pre‐glucarpidase methotrexate levels, glucarpidase efficacy at inducing CIR in pediatric/young adult patients was consistent, with efficacy observed in the overall study population (i.e., patients aged 0–84), and no unexpected safety findings were observed. These findings demonstrate glucarpidase (50 U/kg) is an effective and well‐tolerated dose for pediatric, adolescent, and young adult patients.
Influence of extrusion pressures on shape memory properties of carbon fiber/basalt fiber hybrid composites with graphene oxide fabricated by the vacuum infiltration hot pressing system
Authors: Xu Yi , Ma Yuqin , Li Puda , Zhang Yuyang , Guo Haiyin , Xu Wei , Song Chen , Lv Jinshu 
Published: June 2023

AbstractThis work investigated the extrusion pressure‐microstructure‐shape memory properties relationship of carbon fiber/basalt fiber hybrid composites with graphene oxide (GO‐CF/BF hybrid composites), and the associated mechanism was systematically discussed. GO‐CF/BF hybrid composites were fabricated by the vacuum infiltration hot pressing system (VIHPS). The critical infiltration pressure of the composite was calculated according to the dynamic infiltration model, and it was 0.09 MPa. The microstructure and shape memory properties were analyzed by scanning electron microscopy (SEM) and a shape memory testing system. The results showed that the shape fixation ratio first decreased and then increased, but the shape recovery ratio and the shape recovery force tended to initially increase and subsequently decrease with the increase in extrusion pressure. This was mainly determined by void defects. When the extrusion pressure was 0.5 MPa, the shape memory properties of the composite were excellent. Furthermore, with the increase in cycle times, GO‐CF/BF hybrid composites were damaged, and the shape memory properties all decreased. When the extrusion pressure was 0.7 MPa, fiber fracture and delamination appeared in composites, and the shape memory properties deteriorated significantly. However, when the extrusion pressure was 0.5 MPa, the fiber was fractured slightly, and the shape memory properties degenerated vaguely.
Editing of rice (Oryza sativa L.) OsMKK3 gene using CRISPR/Cas9 decreases grain length by modulating the expression of photosystem components
Authors: Qing Dongjin , Chen Weiwei , Huang Suosheng , Li Jingcheng , Pan Yinghua , Zhou Weiyong , Liang Qiongyue , Yuan Jinghua , Gan Dongmei , Chen Li , Chen Lei , Huang Juan , Zhou Yan , Dai Gaoxing , Deng Guofu 
Published: June 2023

AbstractGrain size is one of the most important agronomic traits for grain yield determination in rice. To better understand the proteins that are regulated by the grain size regulatory gene OsMKK3, this gene was knocked out using the CRISPR/Cas9 system, and tandem mass tag (TMT) labeling combined with liquid chromatograph‐tandem mass spectrometry analysis was performed to study the regulation of proteins in the panicle. Quantitative proteomic screening revealed a total of 106 differentially expressed proteins (DEPs) via comparison of the OsMKK3 mutant line to the wild‐type YexiangB, including 15 and 91 up‐regulated and down‐regulated DEPs, respectively. Pathway analysis revealed that DEPs were enriched in metabolic pathways, biosynthesis of secondary metabolites, phenylpropanoid biosynthesis, and photosynthesis. Strong interactions were detected among seven down‐regulated proteins related to photosystem components in the protein‐protein interaction network, and photosynthetic rate was decreased in mutant plants. The results of the liquid chromatography‐parallel reaction monitoring/mass spectromery analysis and western blot analysis were consistent with the results of the proteomic analysis, and the results of the quantitative reverse transcription polymerase chain reaction analysis revealed that the expression levels of most candidate genes were consistent with protein levels. Overall, OsMKK3 controls grain size by regulating the protein content in cells. Our findings provide new candidate genes that will aid the study of grain size regulatory mechanisms associated with the mitogen‐activated protein kinase (MAPK) signaling pathway.
Hybrid porous polymers based on double‐decker and cage‐ype silsesquioxanes for the high‐efficiency removal of neonicotinoid insecticides and dyes
Authors: Zhao Xiaohan , Liu Hongzhi 
Published: June 2023

AbstractDifferent ratios of octavinylsilsesquioxane (OVS) reacted with phenyl‐substituted double‐decker silsesquioxane (Ph‐DDSQ) via the simple Friedel‐Crafts reaction provides several innovative silsesquioxane‐based porous polymers (PCS‐ODs). The hybrid polymers show adjustable porosity (specific surface areas of 1235 m2 g−1 and large pore volumes >1.07 cm3 g−1). FTIR, SEM, BET, TGA, solid‐state 13C and 29Si MAS NMR spectra were employed to fully characterize these hybrid materials. They display good adsorption capacities for neonicotinoid insecticides (imidacloprid [IMI], acetamidine [ACE] and thiamethoxam [THI]), with capacities up to 117 ± 2, 70 ± 1 and 61 ± 4 mg g−1, respectively. Dyes (Congo red [CR] and rhodamine B [RB]) can also be sufficiently removed, the adsorption capacities are 1822 ± 4 and 912 ± 3 mg g−1. In addition, PCS‐ODs can be cycled at least five times.
Water‐Stable Fluorous Metal–Organic Frameworks with Open Metal Sites and Amine Groups for Efficient Urea Electrocatalytic Oxidation
Authors: Wang Jinhu , Abazari Reza , Sanati Soheila , Ejsmont Aleksander , Goscianska Joanna , Zhou Yingtang , Dubal Deepak P. 
Published: June 2023

AbstractUrea oxidation reaction (UOR) is one of the promising alternative anodic reactions to water oxidation that has attracted extensive attention in green hydrogen production. The application of specifically designed electrocatalysts capable of declining energy consumption and environmental consequences is one of the major challenges in this field. Therefore, the goal is to achieve a resistant, low‐cost, and environmentally friendly electrocatalyst. Herein, a water‐stable fluorinated Cu(II) metalorganic framework (MOF) {[Cu2(L)(H2O)2]·(5DMF)(4H2O)}n (Cu‐FMOF‐NH2; H4L = 3,5‐bis(2,4‐dicarboxylic acid)‐4‐(trifluoromethyl)aniline) is developed utilizing an angular tetracarboxylic acid ligand that incorporates both trifluoromethyl (–CF3) and amine (–NH2) groups. The tailored structure of Cu‐FMOF‐NH2 where linkers are connected by fluoride bridges and surrounded by dicopper nodes reveals a 4,24T1 topology. When employed as electrocatalyst, Cu‐FMOF‐NH2 requires only 1.31 V versus reversible hydrogen electrode (RHE) to deliver 10 mA cm−2 current density in 1.0 m KOH with 0.33 m urea electrolyte and delivered an even higher current density (50 mA cm−2) at 1.47 V versus RHE. This performance is superior to several reported catalysts including commercial RuO2 catalyst with overpotential of 1.52 V versus RHE. This investigation opens new opportunities to develop and utilize pristine MOFs as a potential electrocatalyst for various catalytic reactions.
Isostructural Synthesis of Iron‐Based Prussian Blue Analogs for Sodium‐Ion Batteries
Authors: Liu Yijie , Fan Siwei , Gao Yun , Liu Yang , Zhang Hang , Chen Jian , Chen Xiaoyang , Huang Jiaqi , Liu Xiaohao , Li Li , Qiao Yun , Chou Shulei 
Published: June 2023

AbstractRechargeable sodium ion batteries (SIBs) have promising applications in large‐scale energy storage systems. Iron‐based Prussian blue analogs (PBAs) are considered as potential cathodes owing to their rigid open framework, low‐cost, and simple synthesis. However, it is still a challenge to increase the sodium content in the structure of PBAs and thus suppress the generation of defects in the structure. Herein, a series of isostructural PBAs samples are synthesized and the isostructural evolution of PBAs from cubic to monoclinic after modifying the conditions is witnessed. Accompanied by, the increased sodium content and crystallinity are discovered in PBAs structure. The as‐obtained sodium iron hexacyanoferrate (Na1.75Fe[Fe(CN)6]0.9743·2.76H2O) exhibits high charge capacity of 150 mAh g−1 at 0.1 C (17 mA g−1) and excellent rate performance (74 mAh g−1 at 50 C (8500 mA g−1)). Moreover, their highly reversible Na+ ions intercalation/de‐intercalation mechanism is verified by in situ Raman and Powder X‐ray diffraction (PXRD) techniques. More importantly, the Na1.75Fe[Fe(CN)6]0.9743·2.76H2O sample can be directly assembled in a full cell with hard carbon (HC) anode and shows excellent electrochemical performances. Finally, the relationship between PBAs structure and electrochemical performance is summarized and prospected.
Ni Single Atoms Embedded in Graphene Nanoribbon Sieves for High‐Performance CO2 Reduction to CO
Authors: Zhang Shilei , Yue Pengtao , Zhou Yue , Li Jun , Zhu Xun , Fu Qian , Liao Qiang 
Published: June 2023

AbstractNi single‐atom catalysts (SACs) are appealing for electrochemical reduction CO2 reduction (CO2RR). However, regulating the balance between the activity and conductivity remains a challenge to Ni SACs due to the limitation of substrates structure. Herein, the intrinsic performance enhancement of Ni SACs anchored on quasi‐one‐dimensional graphene nanoribbons (GNRs) synthesized is demonstrated by longitudinal unzipping carbon nanotubes (CNTs). The abundant functional groups on GNRs can absorb Ni atoms to form rich Ni–N4–C sites during the anchoring process, providing a high intrinsic activity. In addition, the GNRs, which maintain a quasi‐one‐dimensional structure and possess a high conductivity, interconnect with each other and form a conductive porous framework. The catalyst yields a 44 mA cm−2 CO partial current density and 96% faradaic efficiency of CO (FECO) at −1.1 V vs RHE in an H‐cell. By adopting a membrane electrode assembly (MEA) flow cell, a 95% FECO and 2.4 V cell voltage are achieved at 200 mA cm−2 current density. This work provides a rational way to synthesize Ni SACs with a high Ni atom loading, porous morphology, and high conductivity with potential industrial applications.
Low‐dimension confinement effect in COF‐based hetero‐photocatalyst for energy‐conversion application
Authors: Yang Yafei , He Dong , Feng Xiaobo , Xiao Xiangheng 
Published: June 2023

AbstractCovalent organic framework (COF) materials have aroused tremendous interest in photocatalytic applications due to their tunable pore structure and photoelectric properties. The regular nanopore of COF itself presents a strongly confinement effect, which provides a unique regulatory effect for photons, electrons, protons, and other quantum‐scale reaction groups. However, due to the weak surface electron coupling and transfer ability between the reactive groups and basic elements of its structural units, the activity of pure COFs photocatalyst is still not satisfactory. Therefore, the confinement modification strategy of confining low‐dimension entities within COFs has been proposed, thus realizing new active sites construction and band structure regulation has been intensively studied, but yet to be summarized systematically. In this paper, the semi‐conductivity of COFs is discussed dialectically based on photocatalytic thermodynamics, and the influence of internal linkage motifs and stacking behaviors on the band structure is collected. Then, the basic understanding of confinement characteristics and their influence on photocatalytic performance in dynamics is further explained according to the spatial dimension classification of low‐dimension entities. And the application and mechanism of these COF‐based confined catalysts in energy conversion reactions are discussed in detail. Lastly, the current challenges and development prospects of COF‐based confined hetero‐photocatalysts are discussed.
Triple‐network‐based conductive polymer hydrogel for soft and elastic bioelectronic interfaces
Authors: Chen Yan , Chen Liangpeng , Geng Bowen , Chen Fan , Yuan Yuan , Li Deling , Wang Yi‐Xuan , Jia Wang , Hu Wenping 
Published: June 2023

AbstractConductive polymer hydrogels have greatly improved the compatibility of electronic devices with biological tissues for human–machine interfacing. Hydrogels that possess low Young's modulus, low interfacial impedance, and high tensile properties facilitate high‐quality signal transmission across dynamic biointerfaces. Direct incorporation of elastomers with conductive polymers may result in undesirable mechanical and/or electrical performance. Here, a covalent cross‐linking network and an entanglement‐driven network with conductive poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have been combined. The triple‐network conductive hydrogel shows high stretchability (with fracture strain up to 900%), low impedance (down to 91.2 Ω·cm2), and reversible adhesion. Importantly, ultra‐low modulus (down to 6.3 kPa) and strain‐insensitive electrical/electrochemical performance were achieved, which provides a guarantee for low current stimulation. The material design will contribute to the progression of soft and conformal bioelectronic devices, and pave the way to future implantable electronics.
Otolaryngology residency program factors associated with female resident representation
Authors: Canick Julia E. , Campbell James C. , Woodard Charles R. , Grimm Lars J. , Collins Alissa M. 
Published: June 2023

AbstractObjectiveFemale representation in the field of otolaryngology is lacking. Residency is the first point at which medical school graduates specialize in a chosen field and thus represents an opportunity to recruit and train more female otolaryngologists. This study sought to identify program factors associated with greater female representation among resident physicians.MethodsDepartmental websites of all 124 otolaryngology residency programs in the United States and Puerto Rico were examined for a list of residents. For programs with a resident roster available, the genders of residents, faculty, program directors, and chairpersons were recorded. Location and city population for each program was also recorded, as was female resident representation. Programs were compared using Pearson Chi‐squared univariate tests.Results1,632 residents and 2,605 faculty were included in the analysis of 109 programs. The median female resident representation was 40%. Programs with larger faculty sizes, more female faculty, and urban location were associated with an above‐median female resident representation. Programs with a larger residency cohort approached significance regarding above‐median female resident representation. Higher female faculty representation, program director gender, chairperson gender, and US region were not associated with variation in female resident representation.ConclusionsGreater female otolaryngology residency representation was associated with programs having an urban location and greater numbers of female and total faculty. It was also likely that a larger resident cohort size may affect female resident representation. The proportions of female faculty, program director, and chairperson gender, as well as the US region, were not associated with variation in female resident gender representation.
Simulation and Experiment Revisited: Temporal Data in Astronomy and Astrophysics
Authors: Abelson Shannon Sylvie 
Published: June 2023

AbstractThe ongoing debate in philosophy of science over whether simulations are experiments has so far operated at too high a level of generality. I revisit this discussion in the context of simulation in astronomy and astrophysics, arguing that a specific subclass of simulations that include a significant amount of empirically obtained temporal data count as experiments. This subclass will be a small one, as the majority of simulations in astronomy and astrophysics will still suffer from a sparseness of data. But it remains the case that there exist examples of simulations that are experiments.
What’s in a Survey? Simulation-Induced Selection Effects in Astronomy
Authors: Gallagher Sarah C. , Smeenk Chris 
Published: June 2023

AbstractObservational astronomy is plagued with selection effects that must be taken into account when interpreting data from astronomical surveys. Because of the physical limitations of observing time and instrument sensitivity, datasets are rarely complete. However, determining specifically what is missing from any sample is not always straightforward. For example, there are always more faint objects (such as galaxies) than bright ones in any brightness-limited sample, but faint objects may not be of the same kind as bright ones. Assuming they are can lead to mischaracterizing the population of objects near the boundary of what can be detected. Similarly, starting with nearby objects that can be well observed and assuming that objects much farther away (and sampled from a younger universe) are of the same kind can lead us astray. Demographic models of galaxy populations can be used as inputs to observing system simulations to create “mock” catalogues that can be used to characterize and account for multiple, interacting selection effects. The use of simulations for this purpose is common practice in astronomy, and blurs the line between observations and simulations; the observational data cannot be interpreted independent of the simulations. We will describe this methodology and argue that astrophysicists have developed effective ways to establish the reliability of simulation-dependent observational programs. The reliability depends on how well the physical and demographic properties of the simulated population can be constrained through independent observations. We also identify a new challenge raised by the use of simulations, which we call the “problem of uncomputed alternatives.” Sometimes the simulations themselves create unintended selection effects when the limits of what can be simulated lead astronomers to only consider a limited space of alternative proposals.
Revisiting the Rhetorical Tradition and Acquainting Ourselves with the Virtuous Orator
Authors: Bengtson Erik , Mossberg Oskar 
Published: June 2023

AbstractThis chapter starts taking inventory of the building blocks for a virtue perspective, by drawing on the classical tradition. The view of rhetoric as an integral part of public life is introduced and the rhetorical teachings of Isocrates, Quintilian, and Cicero are discussed, with particular focus on the virtue ethics they develop and how they can aid constructive analysis of present-day issues.
Exploring the Virtue Framework: Environmental Labels, Clean Clothes, and Green Energy Capitalism
Authors: Bengtson Erik , Mossberg Oskar 
Published: June 2023

AbstractThis chapter is the most extensive chapter in the book. It uses the presented framework of virtue critique to examine the role of environmental labels in green marketing and explore how green rhetoric is used in the marketing of clothes, as well as within the Energy Sector. Themes developed include standardized forms for sustainability communication, communicative efficacy, moral legitimacy, temporality, transparency, and the value of rhetorical spaces for prudent corporate communication on complex matters.
Migration in South Asia: Old and New Mobilities
Authors: Rajan S. Irudaya 
Published: June 2023

AbstractThe topic “Migration” is considered as a bedrock of South Asian Civilization. It has the largest Diaspora among the World, with India as a lead. Majority of these workers migrate for either low or semi–skilled jobs. This reader is an attempt to cover some of the important themes including Phenomenon of non- traditional migration in South Asia, Temporary labour migration and caste system, Feminization in the South Asian Migration, Climate and environmental change induced migration that concerns the Migration in South Asia. This reader has also pointed out the impact of migration governance for safe, legal and orderly migration for the future migration in South Asia.