bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guess Who? Identifying individuals from their brain natural frequency fingerprints
Authors: Arana Lydia , Herrera-Morueco Juan José , Santonja Javier , Capilla Almudena 
Published: January 2025

AbstractNeural oscillations are critical for brain function and cognition. Thus, identifying the typical or natural oscillatory frequencies of the brain is an important first step for understanding its functional architecture. Recently, a data-driven algorithm has been developed for mapping the brain’s natural frequencies throughout the whole cortex, free of anatomical and frequency-band constraints. However, an important limitation of this methodology is that it yields robust results only at the group level. Here, we aimed to adapt this algorithm to improve the quality of the single-subject maps of natural frequencies obtained from magnetoencephalography (MEG) recordings. To achieve this goal, we incorporated two modifications to the original method: (1) increasing the number of individual power spectra to be assigned to each k-means cluster, and (2) smoothing across neighboring voxels. To assess the quality of the single-subject maps, we relied on the fingerprinting technique. Our results show a high degree of accuracy in individual identification, both within a single recording session and across separate sessions. Furthermore, we were able to identify individuals by their natural frequency fingerprints, even with a gap of over four years between sessions. This demonstrates the robustness of the single-subject mapping of natural frequencies and opens new opportunities for identification of pathological variations in intrinsic oscillatory activity in individual subjects.
Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain
Authors: Chamessian Alexander , Payne Maria , Gordon Isabelle , Zhou Mingzhou , Gereau Robert 
Published: January 2025

AbstractThe voltage-gated sodium channels (VGSC) NaV1.8 and NaV1.7 (NaVs) have emerged as promising and high-value targets for the development of novel, non-addictive analgesics to combat the chronic pain epidemic. In recent years, many small molecule inhibitors against these channels have been developed. The recent successful clinical trial of VX-548, a NaV1.8-selective inhibitor, has spurred much interest in expanding the arsenal of subtype-selective voltage-gated sodium channel therapeutics. Toward that end, we sought to determine whether NaVs are amenable to targeted protein degradation with small molecule degraders, namely proteolysis-targeting chimeras (PROTACs) and molecular glues. Here, we report that degron-tagged NaVs are potently and rapidly degraded by small molecule degraders harnessing the E3 ubiquitin ligases cereblon (CRBN) and Von Hippel Lindau (VHL). Using LC/MS analysis, we demonstrate that PROTAC-mediated proximity between NaV1.8 and CRBN results in ubiquitination on the 2ndintracellular loop, pointing toward a potential mechanism of action and demonstrating the ability of CRBN to recognize a VGSC as a neosubstrate. Our foundational findings are an important first step toward realizing the immense potential of NaV-targeting degrader analgesics to combat chronic pain.
Derived motor neurons transplantation promotes nerve regeneration in a rodent model of a chronically denervated nerve through delayed adoption of a chronic denervation phenotype
Authors: Cashman Cashman R. , Mi Ruifa , Hoke Ahmet 
Published: January 2025

AbstractAfter acute injury, the peripheral nervous system regenerates more efficiently than the central nervous system, but this advantage is not maintained with chronic injuries. In large animals like humans, the slow rate of axon growth and the long distance between the central nervous system and end organ result in the adoption of a chronically denervated nerve phenotype even in the setting of acute injury: distal areas of the nerve become unable to support regenerating axons, even as the proximal aspect of the acute injury may be appropriately supportive of regeneration. We hypothesized that motor neuron transplantation into the denervated distal stump would maintain the regenerative capacity by effectively reducing the time and distance necessary for regeneration through relay formation as well as by supporting the host Schwann cells responsible for guiding regenerating axons. Using anin vitroassays, we showed the feasibility of relay formation by demonstrating ventral horn to derived-motor neuron synaptogenesis as identified by calcium imaging. Pilot studies of transplantation of embryonic stem cell-derived mouse motor neurons into chronically denervated rat nerves demonstrated improved regenerative capacity in the chronically denervated nerve following a delayed repair paradigm. While host to graft synaptogenesis was not observed, the Schwann cells in the transplanted nerve stump were maintained in a pro-regenerative state despite chronic denervation. These pilot data suggest cell transplantation can delay the adoption of a chronically denervated phenotype primarily by maintaining Schwann cells in a pro-regenerative state.
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue
Authors: Hanak Filip , Swanson Jessica L. , Felczak Krzysztof , Bernstein Kenneth E. , More Swati S. , Rothwell Patrick E. 
Published: January 2025

AbstractAngiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin peptides in the periphery, and can also regulate endogenous opioid signaling by degrading enkephalin peptides in the brain. ACE has two catalytic domains, located in the N-terminal or C-terminal region of the protein, but little is known about the roles that these two catalytic domains play in regulating endogenous opioid degradation in brain tissue. Using acute brain slice preparations from mice of both sexes, we developed methods to study degradation of Met-enkephalin-Arg-Phe (MERF) by ACE, and investigated the role of each ACE catalytic domain in MERF degradation. Using mutant mouse lines with functional inactivation of either the N-terminal domain or the C-terminal domain, we incubated acute brain slices with exogenous MERF at a saturating concentration. The degradation MERF to produce Met-enkephalin was only reduced by N-terminal domain inactivation. Additionally, application of a selective N-terminal domain inhibitor (RXP 407) reduced degradation of both exogenously applied and endogenously released MERF, without affecting degradation of endogenously released Met-enkephalin or Leu-enkephalin. Taken together, our results suggest that the ACE N-terminal domain is the primary site of MERF degradation in brain tissue, and that N-terminal domain inhibition is sufficient to reduce degradation of this specific endogenous opioid peptide. Our results have exciting implications for the development of novel pharmacotherapies that target the endogenous opioid system to treat psychiatric and neurological disorders.
The transformative role of artificial intelligence in leadership and management development: an academic insight
Authors: Vargas Portillo Patricia 
Published: January 2025

Purpose
This study examines the transformative role of Artificial Intelligence in leadership and management development, investigating how AI technologies enhance decision-making processes, talent management, and strategic planning within organizations. The research explores the integration of AI into leadership development programs while maintaining essential human elements of leadership.

Design/methodology/approach
The study employs a theoretical framework analysis focusing on adaptive learning, predictive analytics, natural language processing, and cognitive computing in leadership development. It examines implementation cases from leading organizations and analyzes current applications through case studies of successful AI integration in leadership programs.

Findings
Organizations implementing AI-driven leadership development programs demonstrate significant improvements in management effectiveness and decision-making capabilities. The research reveals that successful integration requires balancing technological innovation with human-centered leadership principles, while addressing potential biases in AI systems through regular monitoring and audits.

Practical implications
The study provides implementation strategies for organizations to integrate AI in leadership development, emphasizing the importance of robust data governance frameworks, hybrid approaches combining AI analytics with traditional mentoring, and the need for structured decision-making frameworks that merge AI-driven insights with human judgment.

Social implications
The use of AI in leadership development has the potential to democratize access to learning opportunities, allowing leaders from diverse backgrounds to receive tailored training and insights. This could contribute to reducing inequalities in professional development opportunities, supporting UN Sustainable Development Goal (SDG) 10 on reducing inequalities. The use of AI in leadership development has the potential to democratize access to learning opportunities, allowing leaders from diverse backgrounds to receive tailored training and insights. This could contribute to reducing inequalities in professional development opportunities, supporting UN SDG 10 on reducing inequalities.

Originality/value
This research contributes to the emerging field of AI-augmented leadership by providing a comprehensive analysis of how organizations can effectively leverage AI technologies while maintaining authentic human connection in leadership development. It offers novel insights into the future direction of leadership development through immersive learning environments.
Impact of board gender diversity on anti-corruption disclosure: analysis in the context of the Sapin II law in France
Authors: Radhouani Roua , Ajina Aymen 
Published: January 2025

Purpose
This paper aims to examine the influence of board gender diversity on corporate anti-corruption disclosure (ACD) and the role of the Sapin II Law.

Design/methodology/approach
The authors used panel data regressions on a sample of French listed firms from 2010–2020. Keywords-based content analysis is used to measure ACD. Additionally, the Difference-in-Differences (DID) model investigate whether the ACD levels with high and low female directors’ changes before and after the Sapin II Law.

Findings
There is a positive relationship between female directors and corporate ACD. This relation is particularly significant in firms who applies the Sapin II Law.

Research limitations/implications
The authors focus solely on larger French listed companies, which may not reflect small and medium-sized businesses. Due to data limitations, the authors could not include demographic factors like age, education and experience that could influence company behavior. Furthermore, self-reported data may not adequately reveal illicit practices within these companies.

Practical implications
The relationship between board gender diversity and corruption disclosure informs policymakers on reforms for female directors. The findings also aid investors and suggest that managers should view gender diversity as a governance tool to reduce corruption.

Originality/value
This paper is original in focusing on ACD and using a DID methodology to assess the impact of the Sapin II Law. It uniquely investigates threshold effects between board gender diversity and ACD and examines the French context, including the Copé-Zimmermann Law’s gender diversity mandate.
The human touch: investigating the importance of anthropomorphism in retaining episodic volunteers
Authors: Rostiani Rokhima , Indarti Nurul 
Published: January 2025

PurposeThe objective of this study is to investigate how anthropomorphic perceptions of a film festival influence volunteers’ intention to continue volunteering. Specifically, it aims to understand the mediating roles of psychological proximity, psychological contract and commitment in shaping this relationship, with a focus on volunteers at film festivals in Indonesia.Design/methodology/approachThe study employs a sequential explanatory mixed method by conducting an online survey towards volunteers and in-depth interview to selected informants. Data from 80 volunteers was analysed using partial least square structural equation modelling (PLS-SEM) to test the hypotheses. Further, in-depth interviews with 15 volunteers were also conducted and the data was analysed using content analysis to obtain deeper understanding of the phenomena.FindingsThis study found that identification provides a positive influence to volunteers’ intention to continue volunteering in a film festival. Identification is influenced by psychological proximity, which also proven to provide positive influence on psychological contract and commitment (identification and contribution). Further, this study also provides empirical evidence that psychological proximity is influenced by aspects of anthropomorphism namely moral virtue and conscious emotions.Originality/valueThis study is the first study to empirically test the anthropomorphism concept to uncover the continuance intention of film festival volunteers. Two mechanisms of anthropomorphism influence intention to continue volunteering: the indirect relationship from moral virtue to intention to continue volunteering and from conscious emotions to intention to continue volunteering.
Navigating turbulence: leadership evolution in crisis management through response–recovery frameworks
Authors: Bhat Zahid Hussain , Saba Nuzhat 
Published: January 2025

Purpose
This study aims to explore the role of organisations and leaders in addressing crises, with a focus on the Coronavirus disease 2019 pandemic. It proposes a conceptual framework that integrates leadership competencies and crisis management, the response–recovery framework, explained through the five-stage cycle starting from crisis identification, crisis planning, crisis containment, crisis recovery, to redesigning crisis management.

Design/methodology/approach
This research relies on an extensive review of literature on leadership and crisis management. A structured bibliometric analysis was conducted using tools like VOSViewer and Scopus, supported by thematic synthesis, to identify key themes and trends.

Findings
This study establishes a response–recovery framework for crisis management. It identifies essential leadership roles and competencies required during various phases of crises, including crisis identification, planning, containment, recovery and redesigning management. It highlights the dynamic evolution of leadership roles and the significance of effective communication, organisational resilience and distributed leadership.

Practical implications
The proposed response–recovery framework provides actionable insights for practitioners to navigate crises effectively. It emphasises the importance of adaptable leadership styles, proactive crisis planning and fostering resilience, offering organisations a roadmap for handling future crises.

Originality/value
This study offers a unique integration of leadership and crisis management literature, presenting a novel framework aligned with the changing demands of crises. Its focus on leadership evolution across crisis stages provides valuable theoretical and practical contributions for scholars and practitioners.
The evolution and development of railway passenger transportation clearing method in China
Authors: Zhou Yin , Fang Wei , Xu Yan , Wang Huaixiang , Liu Lu 
Published: January 2025

PurposeAs an important part of the management of railway passenger transport, the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises. This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method, analyze its characteristics and influences in each stage, identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approachThrough a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century, the basis, mode, subject and object of clearing in different development stages are systematically compared.FindingsIt comprehensively reveals the evolution of the clearing method, sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time. The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/valueThis paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution, including the simplified rules of clearing, enhanced the market adaptability, establishing and perfecting the incentive mechanism, strengthening the construction of informatization, etc. This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking.
Baclofen modulates the immune response after spinal cord injury with locomotor benefits
Authors: de Sousa Nídia , Correia‐Silva Ariana , Pinho Andreia G. , Vidinha‐Mira André , Cainé Laura , Lima Marta F. , Santos Diogo J. , Cibrão Jorge R. , Campos Jonas , Cavaleiro Helena , Pinho Tiffany S. , Afonso João L. , Sampaio‐Marques Belém , Monteiro Susana , Silva Nuno A. , Barreiro‐Iglesias Antón , Salgado António J. 
Published: January 2025

Background and PurposeSpinal cord injury (SCI) is a neurological condition that affects motor and sensory functions below the injury site. The consequences of SCI are devastating for the patients, and although significant efforts have been done in the last years, there is no effective therapy. Baclofen has emerged in the last few years as an interesting drug in the SCI field. Already used in the SCI clinical setting to control spasticity, baclofen has shown important impact on SCI recovery in animal models, such as lampreys and mice.Experimental Approach and Key ResultsHerein, we proposed to go deeper into baclofen’s mechanism of action and to study its role on the modulation of the immune response after SCI, a major process associated with the severeness of the lesion. Using a SCI compression mice model, we confirmed that baclofen leads to higher locomotor performance, but only at 1 mg·kg−1 and not in higher concentrations, as 5 mg·kg−1. Moreover, we found that baclofen at 1 mg·kg−1 can strongly modulate the immune response after SCI at local, systemic and peripheric levels. This is interesting and intriguingly at the same time, since now, additional studies should be performed to understand if the modulation of the immune response is the responsible for the locomotor outcomes observed on Baclofen treated animals.Conclusion and ImplicationsOur findings showed, for the first time, that baclofen can modulate the immune response after SCI, becoming a relevant drug in the field of the immunomodulators.
Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission
Authors: Faggin Sofia , Cerantola Silvia , Caputi Valentina , Tietto Angela , Stocco Elena , Bosi Annalisa , Ponti Alessandra , Bertazzo Antonella , Macchi Veronica , Porzionato Andrea , Savarino Edoardo V. , Giaroni Cristina , Giron Maria Cecilia 
Published: January 2025

AbstractBackground and PurposeInflammatory bowel disease (IBD) patients display genetic polymorphisms in toll‐like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5‐HT and alteration of the neuroimmune crosstalk. In this study, we investigated the impact of TLR4 signalling on mouse ENS dysfunction caused by dextran sulphate sodium (DSS)‐induced ileitis.Experimental ApproachMale C57BL/6J (wild‐type [WT]) and TLR4−/− mice (10 ± 2 weeks old) received 2% DSS in drinking water for 5 days and then were switched to 3‐day regular drinking water. Histological analysis and proinflammatory cytokine mRNA levels were assessed in ileal samples. Gut motility was evaluated by changes in transit of a fluorescent‐labelled marker and isometric neuromuscular responses of ileal full‐thickness segments to receptor and non‐receptor‐mediated stimuli. Alterations in ENS architecture were assessed by confocal immunohistochemistry in longitudinal muscle–myenteric plexus whole‐mount preparations.Key ResultsIn WT mice, DSS treatment caused delayed gastrointestinal transit, ileal myenteric neurodegeneration, reactive gliosis and release of proinflammatory cytokines. Enhanced cholinergic and tachykinergic excitatory tone, increased inducible nitric oxide synthase (iNOS)‐mediated relaxation, and changes in 5‐HT2A and 5‐HT3 receptor‐mediated responses were observed during ileitis in WT mice. TLR4 deficiency reversed most of the functional and morphological abnormalities.Conclusion and ImplicationsOur results demonstrate that TLR4 activity influences the severity of ileitis, neuroglial plasticity, gut motility, and nitrergic and 5‐HTergic neurotransmissions. The neuroimmune interaction between TLR4 and 5‐HT observed in our study appears to be a potential pharmacological target to treat ENS dysfunction implicated in IBD onset/progression.
A Homozygous Variant in HSD17B1 Identified in Women With Poor Ovarian Response
Authors: Ren Jingyi , Ouyang Yan , Wang Shuangyao , Gong Fei , Lu Guangxiu , Lin Ge , Guo Jing 
Published: January 2025

ABSTRACTAn increasing number of patients utilizing in vitro fertilization (IVF) and assisted reproductive technology (ART) are characterized as impaired or poor ovarian responders (PORs). Owing to its unclear molecular etiology, the management of patients with age‐related ovarian characteristics remains a controversial and complex clinical concern. Therefore, it is important to identify and understand the etiological causes behind POR to develop more effective and efficient management strategies for these patients. In this study, we report a homozygous HSD17B1 (accession number: NM_000413.4) variant (c.718‐1G>C) in a patient with POR from a consanguineous family. The proband, a 33‐years‐old woman, exhibited poor ovarian reserve prestimulation parameters (antral follicle count < 5; anti‐Müllerian hormone = 0.386 ng/mL), resulting in the classification of this patient as patient oriented strategies encompassing individualized oocyte number (POSEIDON) group three according to the POSEIDON criteria. Additionally, this patient displayed impaired estradiol production and reduced 17‐ketosteroids secretion and multiple ovarian cysts, which differed from previously reported POR cases. Overall, our findings provide valuable insights for researchers and clinicians into the relationships between the phenotype and genotype of POR and the HSD17B1 gene.