bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon inductors: clinical efficacy and regulation of inflammatory responses in paediatric respiratory infections
Authors: Vakhitov Kh. M. , Sitdikova G. F. , Loskutova E. V. , Vakhitova L. F. , Serdinskaya I. N. 
Published: March 2023

Introduction. The study of the set of mechanisms of inflammation regulation plays an important role in shaping understanding of the local and general protective and adaptive processes in paediatric respiratory infections. The cytokine system is taken as universal, pleiotropic regulators of the cascade of inflammatory, immune and metabolic processes. Nowadays, the drugs with the potential for effecting the course of cytokine reactions are of great interest.Aim. To evaluate the efficacy of the impact of low molecular weight interferon inducers with a wide range of biological activity on the severity of clinical symptoms and the level of pro- and anti-inflammatory cytokines of peripheral blood in paediatric respiratory infections.Materials and methods. 98 children with ARVI aged 4 to 11 years were examined, of which 57 children received meglumine acridone acetate as etiotropic antiviral therapy at recommended age-related doses and were included in the treatment group. 41 children receiving only symptomatic treatment were included in the comparison group.Results and discussions. Clinically, the use of meglumine acridone acetate resulted in decreased duration of the major symptoms of acute viral respiratory infections among children, reduced risk of complications, and decreased inflammatory manifestations. It was shown that the minimum levels of interleukin-1, -4 and -8 were typical for healthy children, which confirmed the activation of cytokine reactions only in the process of development of pathological symptoms from various organs and systems. An increase in all the studied cytokine levels was observed in ARVI, while the dominance in growth of pro-inflammatory cytokines with underlying slightly increased level of anti-inflammatory interleukin-4 was observed in severe general toxic syndrome and catarrhal signs. In similar cases, a balanced decrease in the levels of anti- and pro-inflammatory cytokines and a relatively rapid regression of clinical symptoms was noted during the meglumine acridone acetate therapy.Conclusions. The use of meglumine acridone acetate contributes to the rapid relief of the major clinical symptoms of acute respiratory viral infections, and shortens the duration of the disease. The nature of cytokine reactions can serve as a marker of an unfavourable course of ARVI. The prescription of low-molecular interferon inducers balances an increase in the levels of pro- and anti-inflammatory cytokines of peripheral blood.
Turbulent flow mechanisms in meandering channels with sediment transport
Authors: Sahoo Suchismita , Sharma Anurag 
Published: March 2023

Abstract
This research aims to investigate the near-bed turbulent flow characteristics in a meandering channel with both mobile bed and immobile bed conditions. Experiments were performed in a prismatic rectangular meandering channel with a non-uniform sand bed of size d50 = 0.523mm. The three-dimensional instantaneous fluid velocity was collected using the Acoustic Doppler velocimeter which will provide important results related to the flow turbulence such as mean flow velocity, turbulence intensity, Reynolds shear stress, turbulent kinetic energy, skewness, kurtosis and turbulent anisotropy. The secondary current flow and the exchange of momentum in the form of turbulence kinetic energy, Reynolds shear stress and turbulent intensity at the inner layer of the flow are identified more in a mobile bed condition as compared to an immobile condition, which causes sediment transport. For the inner layer of the flow, turbulence intensity and turbulent kinetic energy are decreased in magnitude and gradually increase in the outer layer of flow for both the bed conditions. Higher turbulence anisotropy is noticed in the mobile bed condition than in the immobile bed condition, which shows more nonuniformities near the bed level for the mobile bed condition. This study may help in understanding the effect of sediment transport due to a turbulent flow structure in a sinuous alluvial channel.
Nawyki żywieniowe młodzieży w szkołach średnich a zaburzenia odżywiania
Authors: Kochman Dorota , Bartkowska Justyna 
Published: March 2023

Wstęp. Nieprawidłowe nawyki żywieniowe wśród młodych ludzi niosą za sobą negatywne skutki zdrowotne, których konsekwencje bywają niebezpieczne.
Cel: Celem niniejszej pracy jest ocena nawyków żywieniowych wiedzy oraz świadomości zdrowego odżywiania wśród badanej młodzieży przez pryzmat ryzyka zaburzeń odżywiania.
Materiał i metody. Za pomocą metody sondażu diagnostycznego i szacowania, przy użyciu ankiety własnego autorstwa badano nawyki żywieniowe młodzieży w kontekście zaburzeń odżywiania. Procedurę badawczą przygotowano w oparciu o oryginalną wersję kwestionariusza EAT-26 i ORTO-15. Badanie przeprowadzono wśród 70 osób w wieku od 15 do 19 lat.
Wyniki. Wykazano, że złe nawyki żywieniowe w badanej grupie wpływają negatywnie na wybranych badanych. Dochodzi do zaburzeń odżywiania m.in. otyłości i nadwagi. Większość przebadanej młodzieży odżywia się zdrowo, nie wykazują oni problemów w sferze fizycznej, psychicznej i społecznej. Mają oni prawidłową masę ciała odpowiednią do ich wieku.
Wnioski. Nieprawidłowe nawyki żywieniowe młodzieży są coraz częstszym problem w dzisiejszych czasach, z którym zmaga się duża grupa społeczeństwa. Nadmierne spożywanie posiłków, brak ich regularności, unikanie pierwszych śniadań, jedzenie posiłków typu fast-food lub z dużą zawartością cukru, prowokowanie wymiotów staje się główną przyczyną nieprawidłowej masy ciała. Prowadzi to do szeregu negatywnych konsekwencji, a mianowicie pogorszeniu ulega zdrowie fizyczne i psychiczne młodych ludzi, a także dochodzi do zaburzeń odżywiania. Większość młodzieży, która została poddana badaniu wykazała się wiedzą z zakresu zdrowego odżywiania i nie wykazała nieprawidłowych zaburzeń odżywiania. Jednakże wśród ankietowanych znalazła się grupa młodzieży, u której konieczne jest wprowadzenie edukacji zdrowotnej, aby mogli oni zacząć niwelować złe nawyki żywieniowe.
Effectiveness of Interactive Digital Decision Aids in Prenatal Screening Decision-making: Systematic Review and Meta-analysis
Authors: Wong Hong Yat Conrad , Asim Saba , Feng Qi , Fu Sherry Xiao-hong , Sahota Daljit Singh , So Po Lam , Dong Dong 
Published: March 2023

Background
Increasing prenatal screening options and limited consultation time have made it difficult for pregnant women to participate in shared decision-making. Interactive digital decision aids (IDDAs) could integrate interactive technology into health care to a facilitate higher-quality decision-making process.

Objective
The objective of this study was to assess the effectiveness of IDDAs on pregnant women’s decision-making regarding prenatal screening.

Methods
We searched Cochrane Central Register of Controlled Trials, MEDLINE, Embase, PsycINFO, World Health Organization International Clinical Trials Registry Platform, Google Scholar, and reference lists of included studies until August 2021. We included the randomized controlled trials (RCTs) that compared the use of IDDAs (fulfilling basic criteria of International Patient Decision Aid Standards Collaboration and these were interactive and digital) as an adjunct to standard care with standard care alone and involved pregnant women themselves in prenatal screening decision-making. Data on primary outcomes, that is, knowledge and decisional conflict, and secondary outcomes were extracted, and meta-analyses were conducted based on standardized mean differences (SMDs). Subgroup analysis based on knowledge was performed. The Cochrane risk-of-bias tool was used for risk-of-bias assessment.

Results
Eight RCTs were identified from 10,283 references, of which 7 were included in quantitative synthesis. Analyses showed that IDDAs increased knowledge (SMD 0.58, 95% CI 0.26-0.90) and decreased decisional conflict (SMD –0.15, 95% CI –0.25 to –0.05). Substantial heterogeneity in knowledge was identified, which could not be completely resolved through subgroup analysis.

Conclusions
IDDAs can improve certain aspects of decision-making in prenatal screening among pregnant women, but the results require cautious interpretation.
SNapp, a Tailored Smartphone App Intervention to Promote Walking in Adults of Low Socioeconomic Position: Development and Qualitative Pilot Study
Authors: Vos Anne L , de Bruijn Gert-Jan , Klein Michel C A , Lakerveld Jeroen , Boerman Sophie C , Smit Edith G 
Published: March 2023

Background
Adults of low socioeconomic position (SEP) are generally less physically active than those who are more socioeconomically advantaged, which increases their cardiovascular disease incidence risk. Moreover, individuals of low SEP are often less easily reached with physical activity (PA) interventions than individuals of higher SEP. Smartphone apps have been presented as a promising platform for delivering PA interventions to difficult-to-reach individuals of low SEP. Although PA apps are widely available, they are rarely based on health behavior theories and most predominantly offer generic PA advice. Consequently, it is unlikely that available apps are the most effective PA intervention tools.

Objective
To respond to these areas for improvement, we developed SNapp, an app-based intervention encouraging adults of low SEP to increase PA by providing tailored coaching messages targeting walking behavior. This study aimed to describe SNapp’s stepwise development and pilot evaluation process.

Methods
We applied a stepwise approach: analyzing the health problem, developing a program framework, developing tailoring assessments, writing tailored messages, automating the tailoring process, and implementing and evaluating the program in a qualitative pilot study (11 participants).

Results
SNapp consisted of several elements. First, an app was developed to collect step count and geolocation data using smartphone sensor functionalities. In addition, a survey measure was created to assess users’ behavior change technique (BCT) preferences. These 3 data types were used to tailor SNapp’s coaching messages to stimulate walking. This allows SNapp to offer feedback on performance levels, contextually tailored prompts when users are near green spaces, and coaching content that aligns with individual BCT preferences. Finally, a server-based Python program that interacts with databases containing user data and tailored messages was built using Microsoft Azure to select and automatically send messages to users through Telegram messenger. Pilot study findings indicated that SNapp was rated positively, with participants reporting that its design, technical functioning, and message content were acceptable. Participants suggested additional functionalities that are worth considering for future updates.

Conclusions
SNapp is an app-based intervention that aims to promote walking in adults of low SEP by offering tailored coaching messages. Its development is theory based, and it is among the first to incorporate contextualized feedback and content tailored to individual BCT preferences. The effectiveness of SNapp will be evaluated in a 12-month real-life parallel cluster-randomized controlled trial.
Co-created Technological Solutions for Caregivers in Health Care: Systematic Review
Authors: Merchán-Baeza Jose Antonio , Borralleras Andreu Cristina , Minobes-Molina Eduard , Grau Carrión Sergi , Romero-Mas Montse , Ramon-Aribau Anna 
Published: March 2023

Background
Support interventions for caregivers can reduce their stress, possibly improving the quality of patients’ care while reducing care costs. Technological solutions have been designed to cover their needs, but there are some challenges in making them truly functional for end users. Co-design approaches present important opportunities for engaging diverse populations to help ensure that technological solutions are inclusive and accessible.

Objective
This study aimed to identify co-created technological solutions, as well as the process followed for their co-creation, in the field of health for caregivers.

Methods
The literature review was conducted in the Medline, Web of Science, Scopus, Science Direct, Scielo, and IEEE Xplore databases. The inclusion criteria were studies written in English or Spanish and with a publication date until May 2021. The content had to specify that the caregivers actively participated in the co-creation process, which covered until the development phase of the technological solution (prototype). The level of evidence and the methodological quality were analyzed when possible, using the Scottish Intercollegiate Guidelines Network criteria and the Mixed Methods Appraisal Tool, version 2018, respectively.

Results
In total, 410 papers were identified, and 11 met the eligibility criteria. The most predominant articles were mixed methods studies and qualitative studies. The technology used in the analyzed articles were mobile or web applications (9 studies) and specific devices such as sensors, cameras, or alarm systems (2 studies) to support the health and social aspects of caregivers and improve their education in care. The most common patient profile was older people (7 studies); 6 studies used co-creation in the requirements phase, 6 studies detailed the design phase. In 9 studies, the prototype was iteratively refined in the development phase, and the validation phase was performed in 5 of the reviewed studies.

Conclusions
This systematic review suggests that existing co-created technological solutions in the field of health for caregivers are mostly mobile or web applications to support caregivers’ social health and well-being and improve their health knowledge when delivering care to patients, especially older people. As for the co-creation process, caregivers are particularly involved during development and in the design. The scarce literature found indicates that further research with higher methodological quality is needed.
A Comparison of Women’s and Men’s Web-Based Information-Seeking Behaviors About Gender-Related Health Information: Web-Based Survey Study of a Stratified German Sample
Authors: Link Elena , Baumann Eva 
Published: March 2023

Background
Gender-sensitive approaches to health communication aim to integrate gender perspectives at all levels of communication, as an individual’s biological sex and socially assigned gender identity have an impact on whether and how one acquires what type of health information. Due to the fast and low-cost opportunity to search for a wide range of information, the internet seems to be a particularly suitable place for gender-related health information about diseases of sex-specific organs and diseases where biological differences are associated with different health risks.

Objective
This study aims to inform gender-related information provision and acquisition in 2 ways. The first objective was to provide a theory-driven analysis of web-based health information–seeking behavior (HISB) regarding gender-related issues. Therefore, the Planned Risk Information Seeking Model (PRISM), which is one of the most integrative models of HISB, was adapted and applied. Second, we asked for gender-specific motivational determinants of gender-related web-based HISB comparing the predictors in the groups of women and men.

Methods
Data from a stratified web-based survey of the German population (N=3000) explained gender-related web-based HISB and influencing patterns comparing women and men. The applicability of PRISM to gender-related web-based HISB was tested using structural equation modeling and a multigroup comparison.

Results
The results revealed PRISM as an effective framework for explaining gender-related web-based HISB. The model accounted for 28.8% of the variance in gender-related web-based HISB. Gender-related subjective norms provided the most crucial explanatory power, followed by perceived seeking control. The multigroup comparison revealed differences in the model’s explanatory power and the relevance of predictors of gender-related web-based HISB. The share of explained variances of web-based HISB is higher in men than in women. For men, norms were a more relevant promoting factor, whereas web-based HISB of women was more strongly associated with perceived seeking control.

Conclusions
The results are crucial for gender-sensitive targeting strategies and suggest gender-related health information interventions that address gender-related subjective norms. Furthermore, programs (eg, web-based learning units) should be developed and offered to improve individuals’ (perceived) abilities to perform web-based searches for health information, as those with higher control beliefs are more likely to access web-based information.
Strategi Pemasaran dalam Peningkatan Penjualan Wine di Hatten Wine Pada Era New Normal
Authors: Krisnaputra Gede Rendi , Sinaga Firman , Supartini Ni Luh 
Published: March 2023

Hatten Wine merupakan salah satu perusahaan wine yang ada di Bali. Dikarenakan situasi pandemi di era new normal penjualan Wine menurun drastis. Walaupun sudah mempunyai event free flow, wine testing dan wine tour, tetap saja tidak dapat meningkatkan penjualan wine di masa pandemi saat ini. Hal ini dilihat dari merosotnya penjualan pada tahun 2021. Penurunan ini diakibatkan karena pandemi dan kurangnya target market ke tamu lokal. Berdasarkan hal tersebut peneliti melakukan penelitian dengan menggunakan strategi pemasaran dengan metode analisis SWOT (strength, weakness, opportunities, threat) dan metode QSPM (quantitative strategic planning matrix) untuk menentukan strategi prioritas yang diperoleh dari analisis SWOT. Dimana hasil dari analisis SWOT menunjukkan Hatten Wine berada pada Kuadran I dimana sumbu X (strength) pada titik 1,33 dan Y (opportunities) berada pada titik 1,2. Dalam situasi ini tindakan yang diambil yaitu menggunakan strategi agresif dimana menagemen sales & marketing harus memperkuat kekuatan yang ada untuk dapat memanfaatkan peluang sebesar-besarnya. Dan untuk strategi prioritas yang digunakan yaitu membuat promosi wine. Membuat member card untuk para repeater dengan bonus atau discount. Membuat event serta mengundang DJ/live music yang memiliki masa banyak untuk meningkatkan jumlah pengunjung dan volume penjualan.

Hatten Wine is one of the wine companies in Bali. Due to the pandemic situation in the new normal era, wine sales have decreased drastically. Even though they already have free flow events, wine testing and wine tours, they still cannot increase wine sales during the current pandemic. This can be seen from the decline in sales in 2021. This decline was due to the pandemic and the lack of a target market for local guests. Based on this, the researchers conducted research using a marketing strategy using the SWOT analysis method (strengths, weaknesses, opportunities, threats) and the QSPM (quantitative strategic planning matrix) method to determine the priority strategies obtained from the SWOT analysis. Where the results of the SWOT analysis show Hatten Wine is in Quadrant I where the X (strength) axis is at 1.33 and Y (opportunities) is at 1.2. In this situation the action taken is to use an aggressive strategy where the sales & marketing management must strengthen the existing strengths to be able to take advantage of the maximum opportunity. And for the priority strategy used, namely making wine promotions. Make member cards for repeaters with bonuses or discounts. Organize events and invite DJs/live music who have a lot of time to increase the number of visitors and sales volume.
Valoración de la disposición a pagar por la protección del Rio Algodonal
Authors: Rodríguez Suarez Alex Mauricio 
Published: March 2023

El presente trabajo pretende identificar la disposición a pagar de los habitantes de Ocaña por la conservación de los servicios ecosistémicos que brinda la cuenca del Rio Algodonal, para ello en la introducción se esboza un marco conceptual de la economía ambiental encaminada a establecer el rol del gobierno como principal responsable de la protección de los recurso naturales, luego utilizando la metodología del marco lógico se realiza una descripción actual de la cuenca del rio que permita identificar los problemas, causas y consecuencias, para así proponer una alternativa de preservación en la cuenca, finalmente definir las variables principales del modelo de valoración contingente que permita establecer las disposición a pagar de los Ocañeros como estrategia de financiación.
Islamic Banking Financial Inclusion and Tax Revenue in OIC Countries: To What Extent do They Correlate?
Authors: Alan Nur Muhammad , Febriyanti Annisa Rahma , Rusgianto Sulistya , Herianingrum Sri 
Published: March 2023

Tax revenue of Organization of Islamic Cooperation (henceforth OIC) countries has not reached the global average, and so has the financial inclusion. Notwithstanding this fact, few researchers have addressed the effect of financial inclusion on tax revenue in the context of Islamic finance while it is undeniably having significant connection to the real sector. Drawing on this crucial issue, the present study calls into the possible effect of Islamic banking financial inclusion on tax revenue in eleven countries of OIC membership consisting of Indonesia, Jordan, Kazakhstan, Kuwait, Malaysia, Nigeria, Oman, Pakistan, Saudi Arabia, Turkey, and the United Arab Emirates in the period of 2013 to 2019. The data were analyzed under the procedure of panel data regression using fixed effect model. The result depicted that Islamic banking financial inclusion, in terms of financial access and financial usage, had no significant effect on tax revenue of the OIC countries. This result is reasonable, since Islamic banking financial inclusion still requires massive promotion particularly by the OIC countries included in this study. Hence, this study leaves an implication for OIC countries to foster Islamic banking financial inclusion as a crucial effort to increase the tax revenue, in which Islamic banks play a promising role for sharia-compliance-based financial transactions in the recent years.