bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of somatosensory processing signs after nociceptive targeted surgery in patients with musculoskeletal disorders: a systematic review
Authors: Vervullens Sophie , Meert Lotte , Meeus Mira , Baert Isabel , Heusdens Christiaan H.W. , Caethoven Cleo , Charpentier Nina , Vervliet Amber , Smeets Rob J.E.M. 
Published: February 2023

Abstract
Surgery is often advised when conservative treatment fails in musculoskeletal pain conditions, but a substantial proportion still suffers chronic pain after surgery. Somatosensory processing system (SPS) signs were previously studied as potential predictors for chronic postsurgical pain, but results are inconsistent. Therefore, studying the evolution of SPS signs could be of added value. The aim was to summarize all studies that measured how SPS signs evolved after nociceptive targeted surgery in musculoskeletal disorders and to find preoperative, perioperative, and postoperative predictors for the evolution of these SPS signs. Data were summarized, and risk of bias and level of evidence and recommendation were determined. Twenty-one studies were included. Five scored a low, 3 a moderate, and 13 a high risk of bias. In general, no consistent evolution of SPS signs comparing preoperative and postoperative values and predictors for this evolution in musculoskeletal disorders could be found. In most cases, static quantitative sensory testing (QST) did not change or conflicting results were found. On the other hand, dynamic QST mostly improved after surgery. Worthfully mentioning is that worsening of SPS signs was only seen at a follow-up of <3 months after surgery, that conclusions are stronger when evaluating dynamic QST with a follow-up of ≥3 months after surgery, and that pain improvement postsurgery was an important predictor. Future high-quality research should focus on the evolution of SPS signs after nociceptive targeted surgery, accounting for pain improvement groups and focusing on preoperative, perioperative, and postoperative predictors of this evolution.
Association between maternal factors and fetal macrosomia in full-term singleton births
Authors: Chen Yu-Hsuan , Chen Wei-Yu , Chang Chia-Yuan , Cho Ching-Yi , Tang Yi-Hsuan , Yeh Chang-Ching , Yang Yi-Hsin , Tsao Pei-Chen , Lee Yu-Sheng 
Published: February 2023

Background:Macrosomia, defined as a birth weight of ≥4000 g, is associated with a high risk of birth injury. Fetal growth is highly correlated with maternal conditions, and several maternal factors are associated with neonatal birth size. The current study aimed to assess maternal factors related to fetal macrosomia in a Taiwanese population.Methods:The medical records of pregnant mothers and their newborns were retrospectively reviewed. All singleton pregnancies delivered at and after 37 weeks of gestation were included in the analysis. Maternal and neonatal conditions were evaluated according to different birth weights.Results:A total of 4262 infants were enrolled in our study. The mean birth weight was 3156 ± 383 g, including 77 (1.8%) cases with birth weight ≥4000 g, and 154 (3.6%) infants with birth weight <2500 g. The mean maternal body weight before delivery was 67.6 ± 10.0 kg. The mean 6-month gestational weight gain (6mGWG) was 12.3 ± 4.2 kg, and the mean maternal body mass index (BMI) was 26.2 ± 3.6 kg/m2. The maternal weight, height, and 6mGWG, gestational age, and placental weight were significantly positively correlated with neonatal birth weight. The odds ratios of macrosomia were 3.1 in neonates born to mothers with a 6mGWG of ≥15 kg, 6.3 in those born to mothers with gestational diabetes mellitus, and 4.1 in those born to mothers with a BMI of ≥30 kg/m2. Newborn macrosomia was associated with adverse events in pregnant mothers and newborn infants.Conclusion:Gestational diabetes mellitus, 6mGWG, and maternal BMI are significantly correlated with neonatal macrosomia in full-term singleton births. Further, neonatal macrosomia is an important cause of maternal and neonatal morbidity. Hence, pregnant women should undergo maternal counseling for weight management before and during pregnancy, and the appropriate delivery method should be identified to prevent perinatal adverse events.
Radiomic features derived from pretherapeutic MRI predict chemoradiation response in locally advanced rectal cancer
Authors: Chou Yen , Peng Szu-Hsiang , Lin Hsuan-Yin , Lan Tien-Li , Jiang Jeng-Kae , Liang Wen-Yih , Hu Yu-Wen , Wang Ling-Wei 
Published: February 2023

Background:
The standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant concurrent chemoradiotherapy (CRT) followed by surgical excision. Current evidence suggests a favorable prognosis for those with pathological complete response (pCR), and surgery may be spared for them. We trained and validated regression models for CRT response prediction with selected radiomic features extracted from pretreatment magnetic resonance (MR) images to recruit potential candidates for this watch-and-wait strategy.

Methods:
We retrospectively enrolled patients with LARC who underwent pre-CRT MR imaging between 2010 and 2019. Pathological complete response in surgical specimens after CRT was defined as the ground truth. Quantitative features derived from both unfiltered and filtered images were extracted from manually segmented region of interests on T2-weighted images and selected using variance threshold, univariate statistical tests, and cross-validation least absolute shrinkage and selection operator (Lasso) regression. Finally, a regression model using selected features with high coefficients was optimized and evaluated. Model performance was measured by classification accuracies and area under the receiver operating characteristic (AUROC).

Results:
We extracted 1223 radiomic features from each MRI study of 133 enrolled patients. After tumor excision, 34 (26 %) of 133 patients had pCR in resected specimens. When 25 image-derived features were selected from univariate analysis, classification AUROC was 0.86 and 0.79 with the addition of six clinical features on the hold-out internal validation dataset. When 11 image-derived features were used, the optimized linear regression model had an AUROC value of 0.79 and 0.65 with the addition of six clinical features on the hold-out dataset. Among the radiomic features, texture features including gray level variance, strength, and cluster prominence had the highest coefficient by Lasso regression.

Conclusion:
Radiomic features derived from pretreatment MR images demonstrated promising efficacy in predicting pCR after CRT. However, radiomic features combined with clinical features did not result in remarkable improvement in model performance.
An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers
Authors: Koskela Kirsi , Sauni Riitta , Uitti Jukka , Oksa Panu , Moilanen Eeva , Hämäläinen Mari , Lehtimäki Lauri 
Published: February 2023

Objective
The aim of the study was to assess whether plasma adipokine levels (adipsin, adiponectin, leptin, and resistin) are associated with pulmonary function in foundry workers.

Methods
We examined 65 dust-exposed foundry workers and 40 nonexposed controls and analyzed their lung function and plasma adipokine levels at baseline and after approximately 7 years of follow-up.

Results
A higher increase in plasma adipsin was associated with the development of airway obstruction in exposed subjects during follow-up after adjusting for body mass index changes during the follow-up period. Furthermore, the increase in adipsin levels was positively associated with cumulative dust exposure even after adjusting for smoking and body mass index changes during follow-up (P = 0.015).

Conclusion
The results suggest that plasma adipsin is involved in the pathogenesis of subclinical airway inflammation and the development of chronic obstruction and is induced by occupational dust exposure.
Workers' Compensation Claims for Conditions Presumed to Be Occupational Diseases Among Firefighters in Washington State, 2000–2017
Authors: LaSee Claire R. , Bonauto David K. , Marcum Jennifer 
Published: February 2023

Objective
Occupational disease presumption laws for firefighters are common, yet little is known about the workers' compensation claims filed for them.

Methods
We identified Washington State’s workers' compensation claims for conditions covered by presumption among firefighters during 2000 to 2017, and described them by disease type and claim characteristics. Claim rates for specific cancers were compared with statewide incidence rates using the Washington State cancer registry.

Results
Firefighters filed 330 claims for conditions covered by presumption (heart problems, 43%; cancer, 35%; respiratory disease, 15%; and infectious diseases, 8%), with acceptance rates varying by disease and insurer type. Cancer claims were associated with the highest claim costs and time loss.

Conclusions
This study provides necessary baseline data to understand the impact of presumption laws on workers' compensation systems, and can inform future decisions presumption law expansions for firefighters.
Associations Between Telework Experience and Psychosocial Working Conditions During the COVID-19 Pandemic
Authors: Svensson Sven , Mathiassen Svend Erik , Hallman David M. , Heiden Marina , Bergström Gunnar 
Published: February 2023

Objectives
The aim of the study are to determine to what extent pre–COVID-19 experience of telework was associated with perceived psychosocial working conditions (PWCs; job demands, social support, and influence at work) during the COVID-19 pandemic among white-collar workers in Sweden and to determine to what extent the association depends on demographic factors, organizational tenure, and amount of computer use.

Methods
Cross-sectional questionnaire data from 603 white-collar workers were collected October to December 2020 in an industrial company.

Results
In general, telework experience was not significantly associated with PWCs. Women who began teleworking because of COVID-19 reported more job demands than women not teleworking. For those who began teleworking because of COVID-19, managerial support increased with age.

Conclusions
In general, telework experience was not associated with PWCs, but telework due to COVID-19 may have influenced PWCs differently depending on gender and age.
Heat-Related Illness Among Workers in British Columbia, 2001–2020
Authors: Weinberger Kate R. , Tamburic Lillian , Peters Cheryl E. , McLeod Christopher B. 
Published: February 2023

Objective
The aim of this study was to describe the incidence of heat-related illness among workers in British Columbia (BC), Canada, 2001–2020.

Methods
Cases of heat-related illness occurring among workers aged 15 years and older were identified from accepted lost-time claims from WorkSafeBC, the provincial workers’ compensation board. Incidence rates were calculated using monthly estimates of the working population from Statistics Canada’s Labour Force Survey as the denominator.

Results
Between 2000 and 2020, there were 528 heat-related illness claims, corresponding to a rate of 1.21 (95% confidence interval, 1.10–1.31) claims per 100,000 workers. Eighty-four percent of claims occurred between June and August. Rates were higher among male workers, younger workers, and among those working in occupations related to primary industry; trades, transport, and equipment operators; and processing, manufacturing, and utilities.

Conclusions
In BC, lost-time claims for heat-related illness occurred disproportionately among certain subgroups of the workforce.
Immigration and Blood Lead Levels Among Asian Populations in the United States
Authors: Xu Jialin , Ji John S. 
Published: February 2023

Objective
The aim of this study was to explore determinants of high BLLs among the Asian population in the United States.

Methods
We used the US nationally representative National Health and Nutrition Examination Survey (NHANES), 2011–2018. We conducted stratified analyses to compare the BLLs of US-born and non–US-born Asians. We used adjusted linear regression to find predictors of high BLLs.

Results
Among 12,563 participants in our analysis, the length of stay in the United States is a predictor of the gradual decrease in BLL among Asian immigrants (P < 0.05). BLLs of immigrants who stayed in the United States for over 50 years were 0.36 μg/dL (95% confidence interval, 0.07 to 0.66) lower than new immigrants, but still higher than their US-born counterparts.

Significance
Asian population in the US has the highest BLLs among all ethnic groups, and the exposure outside of the US among immigrants is likely the driver.
Occupational Firefighting
Authors: Brumfield Lawrence , Miner Sarah , Tydings Donna , Carey Mary 
Published: February 2023

Objective
The purpose of the study is to evaluate the effect of an online educational module in increasing awareness of depression, substance use disorder, and sleep deprivation among firefighters in Monroe County, New York.

Method
Firefighters were recruited via work e-mail and the snowball technique. A quantitative preintervention and postintervention study was used. Participants completed four surveys before and after completing educational online modules.

Results
There was a 5.11% increase in overall knowledge about sleep deprivation, depression, and substance (alcohol) use and a small decrease in the group mean for the depression and sleep deprivation scores after completion of the educational modules.

Conclusion
Increasing content knowledge had a positive effect to participants' self-awareness during the project. Incorporating educational modules into annual firefighting training could provide opportunities to improve sleep deprivation, depression, and substance use.
Circumstances Contributing to Installation, Maintenance, and Repair Worker Death by Suicide
Authors: Soupene Victor A. , Davis Jonathan , Fogner Andrew , Casteel Carri 
Published: February 2023

Objective
To examine risk factors related to death by suicide among installation, maintenance, and repair (IMR) workers compared with workers in other occupational groups.

Methods
The National Violent Death Reporting System (NVDRS) data for the years 2013 to 2018 was used to identify suicide deaths. Circumstance variables were used to examine differences between IMR workers and other workers.

Results
Having a physical health problem (1.13; 95% confidence interval [CI], 1.03 to 1.23) or a diagnosis of posttraumatic stress disorder (1.24; 95% CI, 1.03 to 1.50) was more likely to contribute to IMR worker suicide compared with other occupations. Installation, maintenance, and repair workers were less likely to receive treatment for a mental health diagnosis or substance use disorder (0.88; 95% CI, 0.81 to 0.94).

Conclusions
Additional support for physical health problems, posttraumatic stress disorder diagnoses, and mental health care access among IMR workers may reduce suicide deaths.
Pharmacology
Authors: Bhandal Amrinder , Muhar Harleen K. 
Published: February 2023

Abstract
Spina bifida is one of the congenital neural tube defects that can lead to loss of bladder control, also known as neurogenic bladder. This can lead to recurrent urinary tract infections and subsequent renal function decline if not properly managed. Proper management may include pharmacological care that aims to prevent improper drainage of the bladder directly by utilizing agents such as anticholinergics, urinary antispasmodics, and botulism toxins. In addition to direct care, patients with neurogenic bladder also may require bowel regimens because of concurrent instances of neurogenic bowels.
Prolene Hernia System Maximum Repair: A New Concept in Sports Hernia Surgery
Authors: Da Rosa André M. , Reusch Marcus , Aguzzoli Marcus , Fonseca Mariana K. , Damin Daniel C. 
Published: February 2023

Objective:To describe and present the clinical results of a new surgical treatment for sports hernia.Design:Retrospective cohort study.Setting:Tertiary hospital.Patients:Athletes who underwent sports hernia repair using the proposed technique between July 2006 and June 2020.Intervention:The surgery consists of a combination of a mini-open incision and preperitoneal placement of a three-dimensional bilayer permanent mesh (PHS).Main outcome Measures:The main clinical outcomes of the procedure were reviewed, including incidence of complications, long-term results, and recurrence rate.Results:Ninety-two sports hernia repairs were performed on 87 patients (79 male and 8 female patients, median age 30.2 ± 7.8 years). No intraoperative complications were observed. The mean follow-up was 15 months. Seventy-seven patients (88.5%) successfully resumed preinjury physical activities within 8 weeks; 80 patients (91.9%) within 12 weeks; and 83 (95.4%) within 6 months (median time of 10 weeks). Only one patient reported recurrence of symptoms.Conclusion:Mini-open incision PHS repair seems to be a safe and effective method for treatment of sports hernia, resulting in early return to physical activities, with few complications, and low recurrence rate.
Society for Cardiovascular Angiography and Interventions Shock Classification to Stratify Outcomes of Extracorporeal Membrane Oxygenation
Authors: Mehta Sanket , Fried Justin , Nemeth Samantha , Kurlansky Paul , Kaku Yuji , Melehy Andrew , Char Steven , Masoumi Amirali , Sayer Gabriel , Uriel Nir , Takeda Koji 
Published: February 2023

We applied the Society for Cardiovascular Angiography and Interventions (SCAI) schema to cardiogenic shock (CS) patients treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) to assess performance in this high acuity group of patients.
Records of adult patients receiving VA-ECMO for CS at our institution from 01/2015 to 12/2019 were reviewed. Post-cardiotomy and noncardiogenic shock patients were excluded.
A total of 245 patients were included, with a median age of 59 years [IQR: 48–67]; 159 (65%) were male. There were 34 (14%) patients in Stage C, 82 (33%) in D, and 129 (53%) in E. Of E patients, 88 (68%) were undergoing cardiopulmonary resuscitation. Median ECMO duration decreased with stage (C:7, D:6, E:4 days, P < 0.001). In-hospital mortality increased (C:35%, D:56%, E:71%, P < 0.001) and myocardial recovery decreased with stage (C:65%, D:35%, E:30%, P < 0.001). Acute kidney injury (C:35%, D:45%, E:54%, P = 0.045), acute liver failure (C:32%, D:66%, E:76%, P < 0.001), and infection (C:35%, D:28%, E:16%, P = 0.004) varied among groups. Multivariable analysis revealed age (HR=1.02), male sex (HR=0.62), and E classification (HR=2.69) as independently associated with 1-year mortality. Competing-risks regression identified D (SHR=0.53) and E classification (SHR=0.45) as inversely associated with myocardial recovery.
In patients treated with VA-ECMO for CS, the SCAI classification provided robust risk stratification.
Utility of the CANUKA Scoring System in the Risk Assessment of Upper GI Bleeding
Authors: Goff Sara , Friedman Emily , Toro Butros , Almonte Matthew , Wilson Carlie , Lu Xiaoning , Yu Daohai , Friedenberg Frank 
Published: February 2023

Background:
The Canada-United Kingdom-Adelaide (CANUKA) score was developed to stratify patients who experience upper gastrointestinal bleeding (UGIB) to predict who could be discharged from the emergency department. Our aim was to determine if the CANUKA score could be utilized for UGIB in-patients undergoing endoscopy in predicting adverse outcomes. We additionally sought to establish a CANUKA score cut point to predict adverse outcomes and in-hospital mortality and compare this to established scoring systems.

Methods:
Between January 1, 2018 to June 30, 2019 all patients who underwent upper endoscopy after admission for UGIB were identified. We assigned a CANUKA score and compared the area under the receiver operating curve to established scoring systems.

Results:
Our data set included 641 patients, with a mean age of 59.5±14.5 years. A CANUKA score ≥10 was associated with an adverse outcome [unadjusted odds ratio, 3.08 (1.79, 5.27)]. No patients experienced an adverse outcome with a CANUKA score <4. No patients died with a CANUKA score <6. Those with a CANUKA score of <10 had an in-hospital mortality of 2.1% compared with 6.8% for those with a score ≥10 (P=0.008). AIMS65 had the best area under the receiver operating characteristic curve (0.809) for predicting mortality.

Conclusions:
The CANUKA score may serve utility as a predictor of adverse outcomes and mortality in patients admitted with UGIB undergoing endoscopy. Future studies, ideally prospective and multicenter, will be needed to validate its clinical utility.
Understanding the Role of a Technology and EMR-based Social Determinants of Health Screening Tool and Community-based Resource Connections in Health Care Resource Utilization
Authors: Gupta Deeksha , Self Stella , Thomas Darin , Supra John , Rudisill Caroline 
Published: February 2023

Background:
Health systems are increasingly investing in social determinants of health (SDoH), but there is limited research on how such efforts impact health care resource use. This study presents pilot work on an SDoH screening and referral platform recently implemented in South Carolina’s largest private nonprofit health system.

Objectives:
To assess the feasibility and sustainability of SDoH screening and SDoH-related referrals in a large health system and examine how they affect health resource use.

Research Design:
Observational study using electronic medical records and SDoH screening data from June 1, 2019 to December 31, 2020.

Subjects:
Patients (18 y+) engaged in community health, inpatient case management, or ambulatory care and condition management programs.

Measures:
We describe the use of SDoH screening by providers (community health workers, nurse case managers, and social workers) and SDoH referral volumes among patients. We use multivariate analyses to predict changes in emergency department visits, inpatient admissions (length of stay and volume), and primary care visits from referral volume, SDoH screening question responses, and patient characteristics (eg, comorbidities).

Results:
Of 2687 patients, 662 (24.6%) screened positive for 1 or more SDoH domains. SDoH screening performance remained consistent among providers over time. Six hundred fifty-eight (24.5%) patients received SDoH referrals. Patients receiving an increasing volume of referrals had decreasing primary care visits but their comorbidities moderated this effect.

Conclusions:
The study provides initial descriptive information on SDoH needs, implementation of referrals and resource use, guiding SDoH screening implementation in population health, and care management programs.
Defining ‘control’ of chronic rhinosinusitis
Authors: Sedaghat Ahmad R. , Phillips Katie M. 
Published: February 2023

Purpose of review
Control is a global disease metric defined as the extent to which manifestations of a disease are within acceptable limits. Control serves as the goal of treatment for chronic diseases, such as chronic rhinosinusitis (CRS), that cannot be cured. The objective of this review is to summarize recommendations for assessment of CRS control with a specific focus on how these recommendations align with patients’ and healthcare providers’ perspectives of CRS control.

Recent findings
Several staging systems for CRS control have been developed with the first and most widely recognized by the 2012 European Position Paper on Rhinosinusitis and Nasal Polyps, which was developed through expert opinion. Patients’ and providers’/guideline-based assessments of CRS control frequently do not align. Patients understand the concept of CRS control and their assessment is dominated by the perceived severity of nasal symptoms. In comparison, providers’ and guideline-based assessments of control are more global, incorporating nasal and extra-nasal symptoms, need for systemic antibiotics and corticosteroids, and nasal endoscopy.

Summary
Although more research is needed, future development of CRS control criteria through consensus around explicitly determined perspectives of healthcare providers and patients may one day serve as the foundation for a standardized approach to treatment of CRS.