bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self Control Remaja Broken Home untuk Berintraksi dengan Lingkungan Sosial
Authors: As'ari Jamaludin , Casmini C. 
Published: August 2023

Self control carried out by broken home teenagers is a way to control peaking desires. Broken home families can influence children in interacting with their social environment. The purpose of this research is how broken home youth self-control to interact with the social environment. The method used in this study is qualitative and data collection by telephone and WhatsApp interviews. In this study there are 3 aspects that can describe the subject of a broken home, namely; 1) cognitive point of view: The form of a broken home; which includes the destruction of the household, finances, and loyalty. 2) affective point of view: The influence of parental divorce; which includes separation of residence, cut off communication, harsh words, hurt feelings, high emotional intensity, feeling comfortable with other people, estrangement with parents. and 3) conative point of view: Tendency to behave; which includes speaking in a high tone, and not maximal in self-control. The following is an analysis of the strategies used by broken home youth in controlling themselves by getting used to reading istighfar when the past overshadows them.
Keywords: self control, broken home, social environment
Conceptualization of the Art Crisis: the Experience of Branch sociology
Authors: Popov Evgeniy Aleksandrovich 
Published: August 2023

The subject of the research in the article is the crisis of art, which is considered both exogenous (its occurrence is associated with various external factors) and endogenous, identified as a state of self-sufficiency in the existence of art. The emphasis is placed on the analysis of the experience of the sociology of art in understanding the crisis and crisis as a factor in the development of time and man. An assessment of the theorizing about the crisis of art at the interdisciplinary level is given, and the main emphasis is placed on the potential of sociological knowledge in stating the state of art under study. In addition, the main directions of conceptualization of the crisis of art in science are revealed. The main conclusions of the study are the following key provisions: 1) conceptualization of the crisis of art within the framework of the relevant branch of sociology is carried out both in terms of understanding art as a form of public consciousness, and from the point of view of the correlation of form and content, as well as ideological and artistic potential; 2) conceptualization of the crisis of art is an independent perspective of scientific research that sets the task of objectifying the crisis of art, understanding the basic laws of its occurrence 3) the sociology of art identifies the crisis of art as a state in which the role of art in the socialization and inculturation of the individual decreases.
Tailored modulation of S100A1 and RASSF8 expression by butanediamide augments healing of rotator cuff tears
Authors: Lin Yuan , Guo Ruipeng , R Geng , Xu Bin 
Published: August 2023

Objectives
This investigation sought to elucidate promising treatment modalities for rotator cuff tears (RCTs) by delving into the molecular machinations instigating the affliction. The focus was on differentially expressed genes (DEGs) linked to RCTs, and the exploration of their roles and operative pathways.

Methods
DEGs were discerned from GEO datasets, followed by the establishment of a protein-protein interaction (PPI) network. Subsequently, the network’s core genes were determined employing a Venn diagram. Enrichment analysis facilitated the unveiling of the biological roles and signal transduction pathways of these pivotal genes, thus shedding light on molecular strategies for RCT-targeted treatment. The Discovery Studio 2019 software was employed to sift through FDA-sanctioned drugs targeting these essential proteins. Moreover, the efficaciousness of these FDA-endorsed drugs vis-à-vis RCTs was corroborated by the construction of an in vivo animal model of the injury and the in vitro cultivation of tendon-derived stem cells.

Results
Bioinformatics outcomes revealed a significant overexpression of S100A1 and RASSF8 in RCT patients. The FDA drug repository indicated that Butanediamide has a selective affinity for S100A1 and RASSF8. Subsequent in vivo and in vitro experimentation demonstrated that Butanediamide could suppress S100A1 expression and bolster TDSC proliferation, thereby facilitating RCT healing.

Conclusions
S100A1 and RASSF8 are pivotal genes implicated in RCTs, and their roles have been elucidated. The FDA-approved compound, Butanediamide, may represent a prospective therapeutic agent for RCTs by targeting S100A1 and RASSF8, respectively.
Investigating the Correlation and Principal Component of Quantitative Traits in Mixed Cropping of Okra and Cucumber
Authors: Sadeghizadeh Malihe 
Published: August 2023

Aims: With the aim of Choosing the most appropriate treatment and investigating the relationships between the traits and investigating the correlation and principal component analysis (PCA) of the morphological and physiological traits, an experiment was conducted in the form of a randomized complete block design (RCBD) in 3 replications on mixed cropping of okra and 3 varieties of cucumber in greenhouse.
Study Design: In order to conduct the experiment, a randomized complete block design was used (RCBD) in three replications.
Place and Duration of Study: This study was conducted in Damavand region of Iran in 2019-2020.
Methodology: This experiment was conducted in a metal frame greenhouse where the average temperature of the greenhouse was 25°C and the relative humidity was 40%. During the harvest season, 3 cucumber plants and one okra plant were randomly sampled and recorded, and the numerical value of each trait was recorded based on the average of 3 random plants.
Results: The results obtained from the correlation coefficients indicated that the trait of dry fruit yield has a positive and significant correlation with the traits of fruit weight and fresh fruit yield. Also, in examining the correlation graph between the traits, dry fruit yield and wet fruit yield traits had positive correlations with chlorophyll a, number of fruits, total chlorophyll and plant height traits. Based on the main components, 4 components accounted for more than 55% of the total variance of the data, respectively, 16% related to the first component, 14% related to the second component, 11% related to the third component, and 10% related to the fourth component. Graphical analysis was used on the data obtained from the experiment. Based on the ranking diagram of treatments in terms of traits, A1B2 (Baker x Mito) and A1B1 (Baker x NEGIN ) treatments were selected as suitable treatments.
Conclusion: Comparison of the treatments with the okra single cropping treatment showed that doing mixed cropping of okra: cucumber can have a great effect on increasing the level of desirability in various traits in the target crop.
Adult Onset Still’s Disease Revealed by a Cardiac Tamponade: A Case Report
Authors: Essaket Imane , Cherki Assala , El-Jamili Mohammed , El-Hattaoui Mustapha 
Published: August 2023

Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disease of unknown origin with various clinical manifestations. In this article, we describe a case of 57-year-old presenting with Still's disease complicated by cardiac tamponade.
This case highlights the importance of a prompt diagnosis of cardiac involvement in inflammatory diseases, as it can be fatal, and underlines the utility of echocardiographic evaluation not only in symptomatic patients, but also for the systematic detection of pericardial effusions. The case of hemodynamic compromise, it allows the provider to determine the timing, approach, and method of pericardial drainage due to cardiac tamponade being a very rare complication that requires an invasive approach.
Estimates of Genetic Variability, Heretability, Genetic Advance and Genetic Divergence in Bottle Gourd [Lagenaria siceraria (Mol.) Stadle.]
Authors: Singh Tribhuwan , Singh P. K. , Singh R. B. , Yashvardhan Vidyasagar , Kumar Abhishek , Singh Dinesh , Pandey Avanish 
Published: August 2023

The present investigation was conducted at Department of Vegetable Science, Chandra Shekhar Azad University of Agriculture and Technology, Kanpur-208002 (UP) during Kharif season in 2022. During the study the analysis of variance for 32 genotypes of Bottle gourd in the randomized block design and revealed significant difference for all the 11 characters, this indicated the presence of wide spectrum of variability among the genotypes. The phenotypic coefficient of variation (PCV) was higher than the respective genotypic coefficient of variation (GCV) for all the traits, a narrow difference between PCV and GCV were recorded for all of the traits. High heritability and genetic advance as per cent of mean were observed for all eleven characters. The highest heritability was recorded in vine length and lowest for number of primary branches. The analysis of genetic divergence through Mahalanobis D2 statistics revealed that a considerable genetic diversity was found among genotypes. 32 genotypes of bottle gourd were grouped into 5 clusters. Out of the 5 clusters, Cluster IV had ten genotypes, Cluster III had eight genotypes, Cluster II had eight genotypes, Cluster I had three genotypes and Cluster V had three genotypes. Based on present investigation, it was concluded that in general, there was parallelism between genetic and geographic diversity. Maximum inter cluster distance was determined between clusters III and cluster V so crosses among genotypes of cluster III like KLG (8), AZAD HARIT ( 9), BG-7505 (10), BG-7127, BG-7512, BG-7306, BG-7502 and BG-7231 can be made as a parent for getting better hybrids.
Treatment of Effluent with an Anaerobic Aerobic Effluent Treatment System
Authors: Dölle Klaus , Lex Simon , Button Nathaniel 
Published: August 2023

Today energy and clean water is a requirement in all societies worldwide to run productive processes. This affects the natural environment negatively and requires establishing more environmentally sustainable processes to decrease dependency and preserve the natural environment.
In this research approach a laboratory anaerobic aerobic effluent treatment system was designed, built, and started up with wastewater. After start-up the system was operated with prepared milk waste, liquid cow manure and wastewater at a hydraulic retention time of 3 days and 6 days.
The laboratory anaerobic aerobic system was able to degrade the chemical oxygen demand, total solids and total suspended solids of all three influent liquids up to 95% and 98% for the 3-day and 6-day hydraulic retention time.
Maximum total solids removal was 87.89% and 92.43% for the 3-day and 6-day hydraulic retention time.
Total suspended solids removal yielded a maximum of 99.87 and 99.93% for the 3-day and 6-day hydraulic retention time.
The anaerobic sludge blanket reactor of the system operated at a temperature of 38°C and a pH between 7.5 and 8.2 achieved a biogas CH4 content of 65% ± 5% and a maximum total biogas production of 2.23 ml/h for the milk waste at a 3-day hydraulic retention time and a minimum biogas production of 1.36 ml/h for the waste water the 3-day and 6-day HRT respectively.
The operation of the designed laboratory anaerobic aerobic effluent treatment system showed that it is capable of reducing the effluent loading of a variety of waste streams as well as producing biogas that can be converted into bio-energy.
Comparative Study of In vitro Cytotoxic Effect of Leaves and Stems Extracts of Clitoria ternatea by Brine Shrimp Lethality Assay
Authors: Pal Arna , Chakraborty Sudipta , Roy Abani , Bala N. N. 
Published: August 2023

Aim: The present study aims at the comparison of cytotoxic effect of methanolic extracts of leaves and stems of Clitoria ternatea (Fabaceae) by brine shrimp lethality assay.
Methodology: Dried leaves and stems were macerated with methanol separately and preliminary phytochemical screenings were carried out. Hatched brine shrimp nauplii were chosen for the assay. The effect was assessed by calculating % mortality of nauplii with different concentrations of the test extracts (1, 10, 25, 50, 100, 500 and 1000 μg/ml) and standard vincristine sulphate. All sets were performed in triplicate.
Results: The extracts of leaves and stems revealed to possess chiefly alkaloids, phenols and flavonoids. Both the extracts exhibited promising outcomes in dose dependant manner while significant responses in most of the doses were also calculated. Leaves were found to be more potent (LC50 value of 276.29 µg/ml.) compared to the stems (LC50 value of 322.95 µg/ml.). All the doses of the standard Vincristine sulphate were found to display significant activity compared to the control and was calculated to have LC50 value of 11.75 µg/ml.
Conclusion: The methanolic extracts of leaves and stems have shown potential cytotoxicity against brine shrimp which were highly comparable with standard. Further work on isolation, characterization and tests on cell lines may lead to identification of active principles.
Macro, Micro, and Everything in Between. Bridging the Gap: A Vision Toward the Creation of Multiscale Vascular Networks
Authors: Pirraco Rogério Pedro 
Published: August 2023

AbstractVascularization is a key issue for the clinical translation of tissue engineering strategies. This has been recognized in the field for almost two decades. Several strategies to solve this issue are proposed but none has decisively tackled the problem. This is in part due to an excessive focus on microvascularization that ignores the need of having macrovessels capable of being surgically connected to the patient's circulation upon implantation. Indeed, a strategy for macrovessel engineering must co‐exist with a strategy for microvessels. And if this is true, all the intermediate scales have to be addressed as well. Therefore, multiscale vascular networks must be the focus of tissue engineering vascularization efforts. In this work, a reflection is made on a possible path forward for researchers and engineers in the field to achieve the ultimate goal of efficient vascularization of engineered tissues and organs.
High Performance and High Yield Solution Processed IGZO Thin Film Transistors Fabricated with Low‐Temperature Annealed Hafnium Dioxide Gate Dielectric
Authors: Liu Yutong , Yu Yang , Li Tianzhi , Hu Yihong , Unnithan Ranjith , Skafidas Efstratios 
Published: August 2023

AbstractSolution‐processed microelectronics offer advantages, including cost‐effectiveness, higher energy efficiency, and compatibility with rapid prototyping compared to their counterparts fabricated through traditional semiconductor manufacturing processes. Unfortunately, solution‐processed transistors exhibit wide performance variability and low yield. In this work, a solution‐processed transparent indium gallium zinc oxide (IGZO) thin film transistor with a low temperature‐annealed hafnium oxide dielectric layer is described. Post‐annealing temperatures for the sol–gel hafnium dioxide thin film are reduced to below 200 °C, significantly expanding the range of substrates on which the metal oxide dielectric can be deposited. The fabricated devices exhibit excellent characteristics with high field‐effect mobilities of over 85 cm2 V−1 s−1, along with low subthreshold swing below 140 mV dec−1, high on/off ratios, and near‐zero threshold voltages when operating stably at low‐operating voltages of 2 V. The solution processed transparent hafnium dioxide gate dielectric IGZO transistors are shown to exhibit comparatively significantly lower device variation and high yield, allowing for the reproducible fabrication of large‐area and transparent solution processed microelectronics systems.
Polymer grafted aramid nanofiber reinforces immiscible waste polypropylene/poly(ethylene terephthalate)
Authors: Martey Shawn , Traywick Andrew , Kelly Jesse C. , Sobkowicz Margaret J. , Chen Wan‐Ting 
Published: August 2023

AbstractPolypropylene (PP) and poly(ethylene terephthalate) (PET) are plastics commonly used for packaging because of their excellent barrier and mechanical properties. The properties of these plastics are often diminished after mechanical recycling, inevitably causing down‐cycling. This problem is exacerbated when different kinds of polymers mix. Aramid nanofibers have the potential to improve the mechanical properties of polymers due to their excellent mechanical properties but their poor dispersion in polymers is a challenge. Grafting polymers onto nanofibers can help address this challenge. In this work, different loading levels (1%, 2%, and 5%) of polymer grafted aramid nanofibers (ANFs) are blended with waste PP/PET (90/10), simulating a PP waste stream containing traces of PET contaminants. Scanning electronic microscopy, rheology, and differential scanning calorimetry results show the affinity of PP functionalized aramid nanofibers (PP_ANF) towards the PP matrix. At 1 wt% of the nanofiber, the size of the PET droplets in the PP matrix of the PP_ANF blend range from 0.2 to 2.0 μm while that of unmodified ANF and PET_ANF blends are in the range of 0.1–6.2 and 0.5–7.4 μm, respectively. In summary, polymer grafted ANFs have the tendency of improving properties of its like polymers due to similarity in the grafting polymer and the polymer matrix.
Organocatalytic Asymmetric Domino [3+2]‐Cycloaddition‐Acyl Transfer Reaction between Azomethine Ylides and α‐Nitro‐α,β‐Unsaturated Ketones
Authors: Sahoo Subas Chandra , Parida Chandrakanta , Pan Subhas Chandra 
Published: August 2023

AbstractHerein we have developed an organocatalytic asymmetric domino [3+2]‐cycloaddition‐acyl transfer reaction between in situ generated azomethine ylides and α‐nitro‐α,β‐unsaturated ketones. The desired penta‐substituted pyrrolidine products were obtained in high yields and in moderate to good enantio‐ and diastereoselectivities. Also, an isomerization reaction in silica gel was performed for the formation of another diastereomer in high yields with retention of enantioselectivities.
Improving statins production: From non‐genetic strategies to genetic strategies
Authors: Fan Dexun , Tang Huayang , Yang Xiaorong , Zhao Fengguang , Han Shuangyan 
Published: August 2023

AbstractStatins are lipid‐lowering drugs that selectively inhibit 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, effectively reducing cholesterol synthesis. With improved nutritional conditions, the demand for statins is increasing in the global market. The use of microbial cell factories for statin biosynthesis has become advantageous due to the rapid advancements in biotechnology. These approaches offer simple operation and easy separation of products. This review provides an overview the strategies for statins production via microbial cell factories, including both traditional fermentation culture (non‐genetic) and modern synthetic biology manufacture (genetic). Firstly, the complex fermentation parameters and process control technology on submerged fermentation (SmF) and solid‐state fermentation (SSF) are introduced in detail. The potential use of recoverable agricultural wastes/(biomass) as a fermentation substrate in SSF for statin production is emphasized. Additionally, metabolic engineering strategies for constructing robust engineering strains and directed evolution are also discussed. The review highlights the potential and challenges of using microbial cell factories for statin production, and aims to promote greener production modes for statins.
UBE2S promotes malignant properties via VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma
Authors: Wu Junyi , Xu Xiangjie , Wu Shasha , Shi Weiwei , Zhang Guang , Cao Yin , Wang Zhongxia , Wu Junhua , Jiang Chunping 
Published: August 2023

AbstractBackgroundUbiquitin‐conjugating enzyme E2S (UBE2S), an E2 enzyme, is associated with the development of various tumors and exerts oncogenic activities. UBE2S is overexpressed in tumors, including hepatocellular carcinoma (HCC). However, the key molecular mechanisms of UBE2S in HCC still need additional research. The aim of this study was to explore the role of UBE2S in HCC.MethodsThe expression levels of UBE2S in HCC tissues and cells were detected by western blot analysis, quantitative real‐time polymerase chain reaction analysis (qRT–PCR), and immunohistochemistry (IHC). A 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay, wound healing assay, colony formation assay transwell assay, and animal models were used to detect the proliferation and migration ability of HCC cells. Western blot analysis, qRT–PCR, immunofluorescence, small‐interfering RNA (siRNA), and plasmid transfection and coimmunoprecipitation (Co‐IP) assays were performed to detect the interaction among UBE2S, von Hippel–Lindau (VHL), hypoxia‐inducible factor 1‐alpha (HIF‐1α), Janus kinase‐2 (JAK2), and signal transducer and activator of transcription 3 (STAT3).ResultsIn this study, we found that high UBE2S expression was associated with poor prognosis in HCC patients. In addition, UBE2S expression was upregulated in HCC tissues and cell lines. Knockdown of UBE2S inhibited the proliferation and migration of HCC cells in vitro and in vivo by directly interacting with VHL to downregulate the HIF‐1α and JAK2/STAT3 signaling pathways. Accordingly, overexpression of UBE2S significantly enhanced the proliferation and migration of HCC cells in vitro via VHL to upregulate HIF‐1α and JAK2/STAT3 signaling pathways. Furthermore, we found that downregulation of UBE2S expression enhanced the sensitivity of HCC cells to sorafenib in vivo and in vitro.ConclusionUBE2S enhances malignant properties via the VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and reduces sensitivity to sorafenib in HCC. The findings of this study may open a new approach for HCC diagnosis and provide a potential option for the treatment of HCC.
Environmental Impact Improvement of Chitosan‐Based Mixed‐Matrix Membranes Manufacture for CO2 Gas Separation by Life Cycle Assessment
Authors: Echarri Itsaso , Casado-Coterillo Clara , Rumayor Marta , Navajas Alberto , Gandía Luis M. 
Published: August 2023

AbstractThe environmental impacts of the manufacture of chitosan (CS) and polymeric poly(1‐trimethylsilyl‐1‐propyne) (PTMSP) mixed‐matrix membranes (MMMs) for CO2 separation by life cycle assessment (LCA) are compared. An ionic liquid of non‐reported toxicity is used in CS membranes to enhance the mechanical strength, and different fillers are used to increase mechanical and functional properties: ETS‐10, ZIF‐8, HKUST‐1, and Zeolite A. Results with the same CO2 permeation flux indicate that ETS‐10/IL‐CS is the membrane manufacture with highest impacts due to its lower permeability. When comparing impacts with same permeation areas, the polymeric one is the membrane with highest impacts. Biopolymer and polymer manufacture are the components with highest contribution to the total environmental impacts of each membrane. To decrease all their impacts below fossil polymer membrane for the same CO2 permeation flux, CS membranes permeabilities should be improved by a numerical factor of 1000, 100, and 2 for the ETS‐10, ZIF‐8, and HKUST‐1/IL‐CS MMMs, respectively.