bluuebunny/crossref_metadata_2025_split huggingface dataset:
High grade upper tract urothelial carcinoma in an ectopic kidney: case report and review of literature
Authors: Kumar Siddhant , Hegde Padmaraj , Agarwal Ankit , Surag K. R. , Doddamani Siddalingeshwara Chandragouda 
Published: January 2025

Abstract

Case
A 67-year-old male with hematuria and diagnosed to have a left iliac fossa malrotated ectopic kidney with enhancing renal pelvic mass; which on histopathological examination was noted to be high grade UTUC- pT3N1.

Conclusion
This is the first documented high grade UTUC case of an ectopic kidney in literature. The treatment of this disease can be challenging due in part to its aberrant vascular morphology and due to its location.
Kernel type-based entries are efficient to develop a core collection of maize (Zea mays L.)
Authors: Son Jae-Han , Hong Seongmin , Kim Ji Won , Go Jiyun , Choi Junyong , Lee Sang-Bum , Ha Jun Young , Go Young-Sam , Bae Hwan-Hee , Jung Tae-Wook , Yi Gibum 
Published: January 2025

Abstract
A core collection, a minimized set of germplasm representing maximum genetic diversity, is useful for breeding and genetic studies. Developing a core collection is essential for efficient genetic analysis. However, the process is time-consuming and requires considerable effort. Based on previous population structures of maize we hypothesized that kernel types can be representative characteristics encompassing large phenotypic variations. Here we showed that kernel type based entries are useful for developing a core collection representing large genetic variation. Based on genome-wide association studies (GWAS) of yellow kernel color and six yield related phenotypes, we found that y1 gene is responsible determinant of yellow color kernel and several genes were revealed to be involved in the yield-related phenotypes. The core collection was powerful to resolve the corresponding genetic components for the phenotypes. These results suggest that kernel types should be considered to include large genetic variation for developing a core collection in maize. This information will be facilitated to develop a new maize core collection.
Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor
Authors: Latif Rauf , Mezei Mihaly , Davies Terry F 
Published: January 2025

Abstract
The pathogenesis of thyroid eye disease (TED) has been suggested as due to signal enhancement in orbital fibroblasts as a result of autoantibody-induced, synergistic interaction between the TSH receptor (TSHR) and the IGF-1 receptor (IGF-1R). This interaction has been explained by a “receptor cross-talk,” mediated via β-arrestin binding. Here we have examined if this interaction can be mediated via direct receptor contact using modeling and experimental approaches.
First, we docked a model of the leucine-rich domain of the TSHR ectodomain (ECD) to an available cryo-electron microscopy-based structure of the active-state IGF-1R dimer and demonstrated the stability of the complex using molecular dynamics simulations. We then extended the complex with the full-length TSHR and the transmembrane helices of the IGF1R and a 3000 ns simulation also showed stability of this complex. We then performed coimmunoprecipitation studies with anti-TSHR and anti-IGF-1R antibodies using cells expressing the IGF-1R and the full-length TSHR and also cells that expressed the IGF-1R and only the TSHR-ECD and, therefore, unable to bind β-arrestin. These studies showed a 360 kD complex protein in the immunoprecipitation, which was present in both the full-length TSHR and the TSHR-ECD-only expressing cells, evidencing a direct interaction of receptors via their ectodomains in the absence of arrestin. Colocalized staining of TSHR and IGF-1R in the TSHR-ECD cells further supported this direct interaction.
These data showed that the TSHR and IGF-1R can interact directly and in the absence of β-arrestin binding. Understanding these interactions is important in the pathogenesis of TED and its therapeutic intervention.
Świętość księdza Józefa Sebastiana Pelczara w duszpasterskiej codzienności Sambora i Wojutycz – emanacja na pokolenia
Authors: Szczych Jan 
Published: January 2025

W roku 2024 mija sto lat od śmierci św. Józefa Sebastiana Pelczara, biskupa przemyskiego (1900–1924). Po otrzymaniu święceń kapłańskich w katedrze przemyskiej w 1864 r., ks. Pelczar został mianowany wikariuszem parafii w Samborze. Był to okres jego pierwotnej gorliwości, inspirowanej chęcią dalszej nauki w Wiecznym Mieście. Po powrocie ze studiów rzymskich, ks. dr Pelczar został ponownie posłany do pracy duszpasterskiej: najpierw do Wojutycz, a następnie znowu do Sambora. Jego drugi pobyt na parafiach ukazuje ks. dra Pelczara jako kapłana pokornego i posłusznego, który pomimo niedowartościowania z oddaniem pełnił zlecone mu obowiązki.
Ks. Pelczar wiernie przestrzegał przyrzeczenia posłuszeństwa władzy duchownej i nie wytyczał sobie swojej życiowej drogi w Kościoła. Jako dobrze uformowany kapłan pokornie poddawał się projektom Opatrzności. Całe jego bogate życie słusznie uzasadnia, że proszącemu, Pan Bóg zawsze daje więcej łask, niż on sam oczekuje (zob. 2 Kor 9, 8).
Comparative study of organic co-solvents on micellar and surface behavior of ionic surfactants: effects of DMSO, acetonitrile, and 1-propanol
Authors: Shah Sujit Kumar , Giri Afshana , Adhikari Sarupa , Bhattarai Ajaya 
Published: January 2025

Abstract
This study investigates the effects of 10 % v/v dimethyl sulfoxide (DMSO), acetonitrile (ACN), and 1-propanol (1-PrOH) on the micellar and surface behavior of three ionic surfactants: sodiumdodecyl sulfate (SDS), dodecyltrimethylammonium bromide (DTAB), and cetylpyridinium chloride (CPC). The addition of co-solvents increased the critical micelle concentration (CMC), with 1-PrOH causing the largest increase due to its strong disruption of the hydrogen bonding network of water. Surface tension measurements revealed a decreased surface excess concentration (Γ
max) indicating reduced surface adsorption. The minimum area per molecule (A
min) increased with organic solvents, particularly in 1-PrOH-water mixtures, reflecting less efficient packing of the surfactant molecules at the surface. The packing parameter (P) decreased in mixed solvents, especially with 1-PrOH, suggesting a shift from spherical to elongated micellar structures. Aggregation numbers (N

agg
) were lower in mixed solvent systems, indicating smaller and less stable micelles. The free energy of adsorption (

∆

G

a
d
s

o

${\increment}{G}_{ads}^{o}$

) became less negative, indicating reduced spontaneity for micelle formation and adsorption, with the strongest impact seen in 1-PrOH. The overall trend of solvent effects was 1-PrOH > ACN > DMSO, highlighting the role of solvent polarity and amphiphilicity in altering surfactant behavior. These results provide valuable insights for the optimization of surfactant-based formulations.
Anogenital Findings in Confirmed Victims of Child Sexual Abuse Materials
Authors: Dai Thanh T. , Spiller Lora R. , Kellogg Nancy D. , Gelfond Jonathan 
Published: January 2025

OBJECTIVE
The purpose of this study is to describe the medical evaluation including history, physical examination, and diagnostic testing results in children/adolescents who are confirmed subjects of child sexual abuse materials (CSAMs) and to compare these findings with age-matched controls who are suspected victims of sexual abuse without CSAMs.

METHODS
This retrospective case-control study examined anogenital findings and disclosure patterns in children who were aged no more than 17 years, who were evaluated for sexual abuse/assault at an urban children’s hospital, and who had additional history of being photographed and/or videotaped while performing sexual acts. Two control patients per study patient were matched by age (± 6 months), gender, acute vs nonacute examination, and type of sexual contact. Photo documentation of all anogenital examinations was reviewed by 2 child abuse pediatricians blinded to the clinical history.

RESULTS
There were 22 cases and 44 controls. Girls comprised 91% (60/66) of the patients. Fourteen cases (14/22; 64%) disclosed details of sexual abuse. Eight cases (36%) did not make a disclosure of sexual abuse; 4 were preverbal. Although half of the cases (12/22; 55%) were evaluated within 120 hours of the most recent sexual abuse contact, only 1 had an abnormal anogenital examination. There were no significant differences in examination findings or diagnostic tests when cases were compared with controls, but more than one-third of cases were preverbal or denied abuse.

CONCLUSION
Children with objective evidence of sexual abuse via CSAMs were unlikely to have examination findings of trauma and were frequently unable/unwilling to fully disclose their abuse.
Water Quality Assessment using Ensemble Learning: Comparative Analysis of Stacking Classifiers for Agricultural Suitability
Authors: Kevin Sherilyn , Singh Santosh Kumar , Bhola Hrushi , Singh Kunal 
Published: January 2025

Abstract

This research explores the use of stacking classifiers with meta-learners to classify water quality for agricultural applications. By leveraging machine learning models such as Logistic Regression, Extra Trees Classifier, K-Nearest Neighbors, and Gradient Boosting Classifier, a robust framework for predicting water suitability was developed. The dataset was preprocessed and augmented to improve model performance. Among the models, the Gradient Boosting Classifier meta-learner achieved the highest test accuracy of 96.01%. The results highlight the potential of machine learning for real-time water quality monitoring, offering a scalable solution to support sustainable agriculture.
Performance Evaluation of Graphene-Supported Electro-Catalysts in Proton Exchange Membrane (PEM) Fuel Cells
Authors: Samanta Samar , Maity Biswajit , Ghosh Avijit , Kuila Sunil Baran , Mandal Biswajit , Bhattacharya Swarnajit 
Published: January 2025

Abstract

The graphene-supported electro-catalysts in proton exchange membrane (PEM) fuel cells were evaluated in this study, and the results show that the output of these cells is positively correlated with the current density, reaching a maximum of about 2.5 W/cm². Problems with energy conversion may be lurking, though, because the efficiency is still very low. Additional investigation into the catalysts' electrochemical dynamics and a reevaluation of the model's loss parameters are warranted in light of the discrepancy between power output and efficiency. In order to enhance the energy efficiency and overall performance of PEM fuel cells, future research should focus on improving the catalyst composition, refining the operating conditions, and using more sophisticated modeling tools.
Association Between Zinc Dietary Intake And Constipation: A Population-based Study
Authors: Liu Xuefeng , Tang Lili , Shen Wei , Mi Nai , Sheng Zewei , Li Chang , Zhang Xiaoming , Lan Weiru , Sun Wanni , Huang Qihui , Tao Hongwu , Liu Yuedong 
Published: January 2025

Abstract

Background: Several studies have proposed a connection between the beginning of constipation and the consumption of dietary micronutrients. However, little study has been done on the possible connection between constipation and ZINC. This study sought to ascertain whether there was a relationship between chronic constipation and dietary zinc intake in adult National Health and Nutrition Examination Survey (NHANES) participants.
Method: Data from the 2009–2010 NHANES health and nutrition survey were used in the study. 24-hour dietary recalls were used to collect dietary information from respondents. Numerous statistical techniques, including interaction testing, subgroup analysis, and curve fitting studies, were used to examine the connection between dietary zinc intake and chronic constipation.
Result: Out of the 3,643 individuals in this research, 270 (7.41%) had a chronic constipation diagnosis. Increasing dietary zinc intake was associated with a decreased incidence of constipation (OR=0.78, 95% CI: 0.68-0.89), with significance at p<0.05, according to a fully adjusted multiple logistic regression analysis. as several factors were taken into consideration, the third tertile's odds ratio and 95% CI were 0.85 (0.74, 0.98), with statistical significance at p<0.05, as compared to the reference group (first tertile). Furthermore, subgroup analysis showed no correlation in most groups, while a certain negative correlation was found in males and alcohol drinkers, particularly in males and alcohol drinkers. In conclusion, this study found a negative association between zinc consumption and the prevalence of chronic constipation. In-depth prospective studies are needed to fully examine the long-term effects of zinc on chronic constipation.
Insights into the Allocation of Pharmaceutical Human Resources and Pharmacy Service Development Evidence from Regional Healthcare Institutions
Authors: Yang Jian , Wei Quanzhi , Jiao Jingyi , Yang Xin , Yang Zaixian , Wen Zhiying , Li Fan 
Published: January 2025

Abstract

Background
The allocation of pharmaceutical human resources and the development of pharmacy services are critical to ensuring effective, safe, and rational medication use within healthcare systems. Regional healthcare institutions, especially in resource-constrained settings, face significant challenges, including workforce shortages, uneven skill distribution, and limited integration of advanced pharmacy practices. This study aims to provide evidence-based insights into workforce allocation and pharmacy service development in these settings.
Methods
A cross-sectional study was conducted across healthcare institutions in Yunnan Province, China, including tertiary, secondary, and primary facilities. Data were collected through a structured questionnaire targeting pharmaceutical personnel actively engaged in service delivery. Variables assessed included demographic and professional characteristics, service participation, and institutional factors. Statistical analyses included descriptive statistics, cluster analysis, multidimensional scaling, and regression analysis to explore patterns and relationships.
Results
The dataset included 2,905 participants, with 78.24% female and 21.76% male respondents. The majority (78%) were aged 20–40 years, and educational attainment was high, with 77.46% holding a bachelor’s degree, 15.93% a master’s degree or higher, and only 6.61% an associate degree or lower. Service participation varied across activities: 50.36% of respondents were involved in medication reconciliation, 47.23% in clinical consultations, and only 24.68% in medication education. Regression analysis revealed that age and professional title were significant predictors of salary, highlighting disparities in career progression and compensation distribution. Cluster analysis identified distinct participation patterns, segregating respondents into high and low engagement groups, underscoring variability in service involvement. The Gini coefficient for salary distribution was 0.17, indicating a relatively equitable distribution.
Conclusions
This study highlights critical challenges and opportunities in the allocation of pharmaceutical human resources and the delivery of pharmacy services in regional healthcare institutions. Findings emphasize the need for targeted training programs, equitable resource distribution, and structured career development pathways. These results provide valuable insights for policymakers and healthcare administrators to enhance workforce development and optimize pharmacy services, particularly in resource-constrained settings.
Cyanobacterial inoculation promotes enhanced clonal growth performance of the aquaticplant Salvinia auriculata.
Authors: Pimenta Larissa Langsdorff , Souza Grécia Andrade , Pereira Luis Carlos , Vaz Marcelo Gomes Marçal Vieira , Demetrio Guilherme Ramos , Coelho Flávia Freitas 
Published: January 2025

Abstract

Clonal plants, like Salvinia auriculata, are widespread and perform important ecosystem functions, influencing the structure and composition of the ecosystems in which they occur. Some cyanobacteria perform biological nitrogen fixation (BNF) and can affect plant growth, as nitrogen (N) is a limiting nutrient. Therefore, we carried out a greenhouse experiment with the inoculation of the cyanobacterial strain Desmonostoc (UFLA 12) to investigate whether heterocystous cyanobacteria favour individual growth and drives reproductive strategies (sexual reproduction and/or clonal growth) of S. auriculata. Salvinia auriculata ramets were grown in plastic pots under the following treatments: (D) Desmonostoc (UFLA 12) inoculum and (Co) control, in which cyanobacteria were absent. The Desmonostoc presence positively influenced the clonal growth of S. auriculata, and increased shoots number, plants fresh biomass, and shoot size. We conclude that the inoculation of Desmonostoc (UFLA 12) contributes to a more vigorous spread of S. auriculata since it enhanced clonal growth. In this sense, the role of Desmonostoc (UFLA 12) as a potential biofertilizer may serve as a tool to assist in understanding the excessive growth of S. auriculata in aquatic environments.
Contributions of International Medical Graduates in the UK to Global Health: Perspectives, Barriers, and Opportunities
Authors: Zangana Goran , Irakoze David 
Published: January 2025

Abstract

Background:
International Medical Graduates (IMGs) form a growing segment of the UK healthcare workforce, with their numbers increasing by 121% since 2017. While their integration challenges are well-documented, their contributions to global health remain underexplored. This study examines the roles, barriers, and opportunities for IMGs practising in Scotland to engage in global health activities.
Results:
Quantitative data from an electronic survey (97 responses; 44% response rate) and qualitative insights from ten structured interviews revealed diverse global health contributions by IMGs. These include voluntary medical missions, capacity-building initiatives, research, collaborative partnerships, and advocacy efforts. However, barriers such as time constraints, limited awareness, financial challenges, and career pressures significantly limit their involvement. Identified facilitators include structural support mechanisms, such as protected time, dedicated funding, logistical aid, and recognition of global health activities within career progression frameworks.
Conclusions:
This study highlights the untapped potential of IMGs in advancing global health. Addressing systemic barriers and implementing supportive policies can empower IMGs to make impactful contributions, ultimately enhancing equitable healthcare development globally.
Pengaruh Customer Satisfaction, Brand Image Dan Customer Trust Terhadap Customer Loyalty
Authors: Rachmat Muhamad Reza 
Published: January 2025

The objective of this research is to identify the influence of customer satisfaction, brand image and customer trust on the loyalty of Netflix users in Malang City. The effects to be identified are both direct and indirect ones from the interactions between the dependent and independent variables. The sample of this quantitative explanatory research is 118 people selected from the population of Netflix users in Malang City. The data analysis was performed using multiple linear regression in IBM Statistics version 26. The results of the research from a series of analysis indicate that customer satisfaction is positively related to customer loyalty, that brand image is positively related to customer loyalty, and that customer trust can also boost a positive relationship with customer loyalty.

Abstrak
Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh Kepuasan Pelanggan, Citra Merek, dan Kepercayaan Pelanggan terhadap Loyalitas Pelanggan pada konsumen Netflix di Kota Malang. Pengaruh yang dimaksudkan pada penelitian ini ialah pengaruh yang terjadi baik secara langsung maupun secara tidak langsung antara variabel independen terhadap variabel dependen. Jenis penelitian ini adalah penelitian eksplanatif menggunakan pendekatan kuantitatif. Penelitian ini menggunakan data sampel sebanyak 118 responden yang berasal dari populasi konsumen Netflix di Kota Malang. Analisis data yang digunakan adalah regresi linear berganda menggunakan IBM Statistik 26. Hasil Penelitian yang dilakukan menggunakan beberapa rangkaian pengujian menunjukkan hasil bahwa kepuasan pelanggan memiliki hubungan positif terhadap loyalitas pelanggan. Selanjutnya pada variabel citra merek juga memiliki hubungan positif terhadap loyalitas pelanggan. Demikian pula dengan kepercayaan pelanggan mampu mendorong hubungan yang terjadi secara positif terhadap loyalitas pelanggan.
Pengaruh Electronic Word of Mouth Terhadap Purchase Intention: Brand Image Sebagai Mediator
Authors: Qatrunnada Rayhan Camila , Fakhri Erie Awalil 
Published: January 2025

Social media are improving and play a crucial role as a promotional instrument for various industries including beauty industry. The objective of this research is to analyze the effect of electronic word of mouth (eWOM) via TikTok on people’s intention to purchase Skintific’s skincare products through the mediation of brand image. The research population is TikTok users who know about Skintific’s products. Using purposive sampling, 140 with the minimum age of eighteen years who know about the said product and who have searched the products’ review in TikTok were selected as the respondents. The data of this quantitative research was acquired from a survey using Google Forms questionnaires and was analyzed using Structural Equation Modeling – Partial Least Squares (SEM-PLS) in SmartPLS 3.2.9. The results show that all of the research hypotheses are accepted in that eWOM positively and significantly influences brand image, brand image positively and significantly affects purchase intention, eWOM significantly impacts purchase intention, and brand image partially mediates the relationship between eWOM and purchase intention.

Abstrak
Media sosial terus berkembang dan berperan penting sebagai alat promosi di berbagai industri, termasuk dalam industri kecantikan. Tujuan dari penelitian ini adalah untuk menganalisa bagaimana pengaruh electronic word of mouth (eWOM) di media sosial Tiktok terhadap minat beli produk skincare Skintific melalui brand image. Penelitian ini mengadopsi pendekatan kuantitatif, dan data dikumpulkan melalui metode survei. Alat pengumpulan data yang digunakan adalah kuesioner yang disebar melalui platform Google Form. Populasi dari penelitian ini merupakan pengguna aplikasi Tiktok yang mengetahui produk Skintific. Penelitian ini menggunakan data sampel sebesar 140 responden yang diambil menggunakan teknik purposive sampling dengan kriteria responden berumur diatas 18 tahun, mengetahui tentang produk Skintific, dan pernah mencari review skintific di aplikasi Tiktok. Analisis data menggunakan Structural Equation Modeling-Partial Least Squares (SEM-PLS) dengan software SmartPLS 3.2.9 Temuan dari penelitian ini mengindikasikan bahwa semua hipotesis yang diajukan dalam penelitian ini dapat diterima. Hasil penelitian ini menunjukkan bahwa eWOM berpengaruh positif dan signifikan terhadap brand image, brand image berpengaruh positif dan signifikan terhadap purchase intention, eWOM berpengaruh signifikan terhadap purchase intention, brand image memediasi hubungan antara eWOM dengan purchase intention secara parsial.