bluuebunny/crossref_metadata_2025_split huggingface dataset:
The soybean immune receptor GmBIR1 regulates host transcriptome, spliceome, and immunity during cyst nematode infection
Authors: Hawk Tracy E. , Piya Sarbottam , Zadegan Sobhan Bahrami , Li Peitong , Rice John H. , Hewezi Tarek 
Published: June 2023

Summary
BAK1‐INTERACTING RECEPTOR LIKE KINASE1 (BIR1) is a negative regulator of various aspects of disease resistance and immune responses.
Here, we investigated the functional role of soybean (Glycine max) BIR1 (GmBIR1) during soybean interaction with soybean cyst nematode (SCN, Heterodera glycines) and the molecular mechanism through which GmBIR1 regulates plant immunity.
Overexpression of wild‐type variant of GmBIR1 (WT‐GmBIR1) using transgenic soybean hairy roots significantly increased soybean susceptibility to SCN, whereas overexpression of kinase‐dead variant (KD‐GmBIR1) significantly increased plant resistance. Transcriptome analysis revealed that genes oppositely regulated in WT‐GmBIR1 and KD‐GmBIR1 upon SCN infection were enriched primarily in defense and immunity‐related functions. Quantitative phosphoproteomic analysis identified 208 proteins as putative substrates of the GmBIR1 signaling pathway, 114 of which were differentially phosphorylated upon SCN infection. In addition, the phosphoproteomic data pointed to a role of the GmBIR1 signaling pathway in regulating alternative pre‐mRNA splicing. Genome‐wide analysis of splicing events provided compelling evidence supporting a role of the GmBIR1 signaling pathway in establishing alternative splicing during SCN infection.
Our results provide novel mechanistic insights into the function of the GmBIR1 signaling pathway in regulating soybean transcriptome and spliceome via differential phosphorylation of splicing factors and regulation of splicing events of pre‐mRNA decay‐ and spliceosome‐related genes.
A MYB activator, DcMYB11c, regulates carrot anthocyanins accumulation in petiole but not taproot
Authors: Duan Ao‐Qi , Deng Yuan‐Jie , Tan Shan‐Shan , Xu Zhi‐Sheng , Xiong Ai‐Sheng 
Published: June 2023

AbstractThe first domesticated carrots were thought to be purple carrots rich in anthocyanins. The anthocyanins biosynthesis in solid purple carrot taproot was regulated by DcMYB7 within P3 region containing a gene cluster of six DcMYBs. Here, we described a MYB gene within the same region, DcMYB11c, which was highly expressed in the purple pigmented petioles. Overexpression of DcMYB11c in ‘Kurodagosun’ (KRDG, orange taproot carrot with green petioles) and ‘Qitouhuang’ (QTHG, yellow taproot carrot with green petioles) resulted in deep purple phenotype in the whole carrot plants indicating anthocyanins accumulation. Knockout of DcMYB11c in ‘Deep Purple’ (DPPP, purple taproot carrot with purple petioles) through CRISPR/Cas9‐based genome editing resulted in pale purple phenotype due to the dramatic decrease of anthocyanins content. DcMYB11c could induce the expression of DcbHLH3 and anthocyanins biosynthesis genes to jointly promote anthocyanins biosynthesis. Yeast one‐hybrid assay (Y1H) and dual‐luciferase reporter assay (LUC) revealed that DcMYB11c bound to the promoters of DcUCGXT1 and DcSAT1 and directly activated the expression of DcUCGXT1 and DcSAT1 responsible for anthocyanins glycosylation and acylation, respectively. Three transposons were present in the carrot cultivars with purple petioles but not in the carrot cultivars with green petioles. We revealed the core factor, DcMYB11c, involved in anthocyanins pigmentation in carrot purple petioles. This study provides new insights into precise regulation mechanism underlying anthocyanins biosynthesis in carrot. The orchestrated regulation mechanism in carrot might be conserved across the plant kingdom and useful for other researchers working on anthocyanins accumulation in different tissues.
Functional responses to multiple sequential abiotic stress (waterlogging‐drought) in three woody taxa with different root systems and stress tolerance
Authors: Quiñones Martorello A. S. , Gyenge J. E. , Colabelli M. N. , Petigrosso L. R. , Fernández M. E. 
Published: June 2023

AbstractThere is generally a trade‐off in the resistance to drought and to waterlogging. However, several species are sequentially subjected to both stressors in many environments. We evaluated the ecophysiological strategies to cope with multiple sequential stress of waterlogging and drought (W + D) of three taxa differing in stress resistance and root morphology: the phreatophic Eucalyptus camaldulensis (Ec) and two shallow‐rooted willow clones: Salix matsudana x Salix alba (SmxSa) and Salix nigra (Sn4). Individuals of the three taxa were grown in pots and assigned to either of four treatments: Control (well‐watered plants), well‐watered followed by drought (C + D); waterlogged for 15 days followed by drought (W15d + D) and waterlogged for 30 days followed by drought (W30d + D). Biomass allocation, growth (diameter, height, length of leaves, and roots), specific leaf area, stomatal conductance, water potential, hydraulic conductivity of roots and branches, leaf C13and root cortical aerenchyma formation were determined at different stages of the experiment. Ec growth was not affected by W + D, developing tolerance strategies at leaf and whole plant levels. Differential effects of W + D were observed in both Salix clones depending on the time of waterlogging. In Sn4 and SmxSa, the root biomass was affected in W15d + D treatment, but a root tolerance response (aerenchyma and adventitious root formation) was observed in W30d + D. In the three taxa, and contrary to expectations, the previous exposure to a waterlogging period did not increase the susceptibility of the plants to a subsequent drought event. On the contrary, we found tolerance, which depended on the time of waterlogging exposure.
Effectiveness of perioperative anticoagulation interruption without heparin bridging on thromboembolic events in patients with atrial fibrillation undergoing elective invasive procedures: a systematic review protocol
Authors: Kaur Jaspreet , Thomas Liza , Bhat Aditya , Barker Timothy Hugh 
Published: June 2023

Objective:
This review will determine whether withholding heparin bridging is superior to bridging in patients with atrial fibrillation requiring temporary interruption of anticoagulation therapy in the perioperative period of an elective invasive procedure.

Introduction:
Atrial fibrillation is the most commonly diagnosed clinical arrhythmia. It is an important cause of cardioembolic events, requiring the use of oral anticoagulation in most patients. It is unclear whether heparin bridging during temporary interruption of anticoagulants has superior outcomes compared with no bridging in the perioperative setting.

Inclusion criteria:
This review will consider studies that compare adults aged 18 years or older; diagnosed with atrial fibrillation; undergoing elective invasive procedures; and who have had oral anticoagulants temporarily withheld with heparin bridging with patients without heparin bridging. Participants will be excluded if they had an alternative reason for anticoagulation or were admitted for emergency surgery. Outcomes will include arterial or venous thromboembolism (including stroke, transient ischemic attack, systemic embolism), major bleeding events, non-major bleeding events, length of hospital stay, and all-cause mortality.

Methods:
The review will follow the JBI methodology for systematic reviews of effectiveness. Databases including MEDLINE, Embase, CINAHL, and CENTRAL will be searched for randomized and non-randomized trials from inception until the present. Two independent reviewers will screen citations by title and abstract, and again at full text. Risk of bias will be assessed using the JBI critical appraisal instrument, and data will be extracted using a modified extraction tool. Results will be synthesized using a random effects meta-analysis and presented in a forest plot. Heterogeneity will be tested for using the standard χ2 and I
2 tests. Overall certainty of evidence will be evaluated using the GRADE approach.

Review registration:
PROSPERO CRD42022348538
An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation
Authors: Basara Gozde , Bahcecioglu Gokhan , Ren Xiang , Zorlutuna Pinar 
Published: June 2023

Abstract
Tissue engineered cardiac patches have great potential as a regenerative therapy for myocardial infarction. Yet, the mutual interaction of cardiac patches with healthy tissue has not been completely understood. Here, we investigated the impact of acellular and cellular patches on a beating two-dimensional (2D) cardiac cell layer, and the effect of the beating of this layer on the cells encapsulated in the patch. We cultured human-induced pluripotent stem cell-derived cardiomyocytes (iCMs) on a coverslip and placed gelatin methacryloyl hydrogel alone or with encapsulated iCMs to create acellular and cellular patches, respectively. When the acellular patch was placed on the cardiac cell layer, the beating characteristics and Ca+2 handling properties reduced, whereas placing the cellular patch restored these characteristics. To better understand the effects of the cyclic contraction and relaxation induced by the beating cardiac cell layer on the patch placed on top of it, a simulation model was developed, and the calculated strain values were in agreement with the values measured experimentally. Moreover, this dynamic culture induced by the beating 2D iCM layer on the iCMs encapsulated in the cellular patch improved their beating velocity and frequency. Additionally, the encapsulated iCMs were observed to be coupled with the underlying beating 2D iCM layer. Overall, this study provides a detailed investigation on the mutual relationship of acellular/cellular patches with the beating 2D iCM layer, understanding of which would be valuable for developing more advanced cardiac patches.
Evaluation of Turbine Tip Clearance With Performance Degradation Using Multilayer Perceptron
Authors: Yang Yue , Mao Junkui , Guo Naxian , Chen Pingting , Wang Feilong 
Published: June 2023

Abstract
This paper developed a process for turbine tip clearance prediction and control considering performance degradation to address the contradiction between computational efficiency and computational accuracy. The developed process consists of an offline high-accuracy database establishment for tip clearance with performance degradation and an online fast tip clearance prediction and control using machine learning. For the former, the steady-state tip clearance is obtained by the calculations for the two-dimensional axisymmetric casing and disk deformations using the finite element method and the one-dimensional blade deformation using the engineering calculation method. The effects of performance degradation, including blade creep and turbine inlet temperature degradation are introduced to update the boundary conditions in gas path and initial clearance. For the latter, the multilayer perceptron is used to realize the fast tip clearance prediction. Considering the independence of component deformations, the tip clearance prediction is achieved by the component deformation predictions, which also reduces the dimension of input parameters for each prediction model and improves the prediction accuracy. Combining the above two parts, the tip clearance with performance degradation can be obtained within 0.00025 s/time, and the maximum absolute error is only 0.012 mm. In addition, with the help of the process, the optimized tip clearance control strategy can be obtained for the performance degradation states, which restores the tip clearance with a 17.66% increment to the initial state without performance degradation. This paper will provide a reference for the tip clearance prediction and control with small computation and high accuracy.
Section VIII, Division 3—Alternative Rules for Construction of High-Pressure Vessels
Authors: Sims J. Robert , Cooch S. Michael 
Published: June 2023

Abstract
This chapter provides a commentary on the ASME Boiler and Pressure Vessel Code, Section VIII, Division 3, 2019 Edition. It is intended to be used as a companion to Division 3 by Manufacturers and Users of high-pressure vessels, and will also provide guidance to Inspectors, materials suppliers, and others. The material is generally presented in the same order in which it appears in the Code. Comments are not given about each paragraph, but paragraph numbers are referenced as appropriate. The comments apply to the 2019 Edition.

History
The original author of this chapter was J. Robert Sims Jr. who updated the chapter for the second, third and fourth editions and was joined by Charles Becht V for the fifth edition. For this revision, Mr. Sims has been joined by S. Michael Cooch.
Section XI Flaw Acceptance Criteria and Evaluation Using Code Procedures
Authors: Cipolla Russell C. 
Published: June 2023

Abstract
For the sixth edition, this chapter has been updated with revised Code requirements and Code Cases from the 2017 Code and 2019 Code Editions. The important areas of revised requirements and procedures include flaw proximity rules in IWA-3300, change in the yield strength limits from 50 ksi to 90 ksi for selected grades of SA-508 and SA-533, addition of stress intensity factor equations for circumferential OD surface flaws in Appendix A, A-3000, revised procedures for pipe flaw evaluation in Appendix C, C-4000 and C-5300, and an updated glossary terminology/definitions. Several new and revised Code Cases are also discussed to include N-513-5 (temporary acceptance of flaws in moderate energy piping systems), N-705-1 (temporary acceptance of flaws in moderate energy vessels and tanks), N-806-1 (evaluation of wall loss in buried pipe), N-848-1 (proximity rules for quasi-laminar flaws), N-869 (extension of N-513 to higher pressures for Class 2 and 3 piping systems), N-877 (characterization of multiple subsurface radially oriented planar flaws), N-889 (new reference curves for irradiated-assisted stress corrosion cracking growth for austenitic stainless steels), N-899 (weld residual stress reference curves for dissimilar metal welds), and N-890 (materials exempted from Appendix G, G-2110(b) requirements). It is important to note that additional proposal changes are being developed by the committees, some of which are discussed in 30.11.

History
Arthur F. Deardorff was the original author of this chapter that was updated by Mr. Deardorff in the second edition. For the third through fifth editions, Russell C. Cipolla revised the entire chapter although retaining certain portions of the previous text, equations, tables, and figures. For the current online edition, Mr. Cipolla has updated using 2017 and 2019 Editions, and additional information as appropriate.
IWE and IWL
Authors: Ferlisi Mark J. , Walden Scott , Staffiera Jim 
Published: June 2023

Abstract
This chapter addresses ASME Code Section XI, Subsections IWE and IWL, for nuclear power plant containments. Subsection IWE provides requirements for preservice and inservice examination/inspection, repair/replacement (R/R) activities, and testing of Class MC (metal containment) pressure-retaining components and their integral attachments and R/R activities. It also provides requirements for testing of Class CC (concrete containment) pressure-retaining components and their integral attachments for boiling water reactors (BWRs) and pressurized water reactors (PWRs). Similarly, Subsection IWL provides requirements for preservice and inservice examination/inspection, R/R activities, and testing of the reinforced concrete and post-tensioning systems of Class CC components for BWRs and PWRs. Together with Subsection IWA, a comprehensive basis is provided for ensuring the continued structural and leak-tight integrity of containments in nuclear power plants. The chapter includes a brief history of the development of ASME Code requirements, the latest information on the U.S. Nuclear Regulatory Commission regulatory review and incorporation of recent ASME Code Editions and Addenda, and current listings of U.S. ‘construction-complete’ commercial nuclear power plants and their containment types and operating status. A summary of recent nuclear industry developments in advanced plant designs and a discussion of the as-yet-unrealized ‘U.S. nuclear renaissance’ are also presented, along with information on the global demand for energy and the current status of commercial nuclear power around the world. Lastly, the current Subsection IWE and IWL Commentaries, as approved and maintained by the ASME Working Group on Containment, are included.

History
The late Robert F. Sammataro authored this chapter for the 1st edition. Jim Staffiera also authored previous revisions of this chapter. The current edition was updated by Mark J. Ferlisi and Scott Walden
Fatigue Crack Growth, Fatigue, and Stress Corrosion Crack Growth: Section XI Evaluation
Authors: Bamford Warren H. 
Published: June 2023

Abstract
Fatigue has often been described as the most common cause of failure in engineering structures, and designers of pressure vessels and piping have incorporated fatigue considerations into design requirements since the first edition of Section III in 1963. The development of this technology and its application in Section III are discussed in Chapter 39 of the third edition of this publication. Its application in Section XI is discussed in Section 32.3 of this chapter.
With the advancement of the state of the art, the ability to recognize how the growth and size of a crack can lead to failure has been enhanced. This technology has been a key aspect of the Section XI flaw evaluation procedures since the 1974 edition was published and will be discussed thoroughly herein.
Further advancements in the state-of-the-art in fracture evaluation resulted in the introduction of models for stress corrosion cracking into Section XI in 2001, and since that time additional models have been added and more are planned. This addition gives Section XI flaw evaluations a complete treatment of all the potential modes of cracking that can occur in components, and details will be provided in Section 32.2.
Since additional crack growth data, for both fatigue and stress corrosion cracking, is periodically made available on a regular basis from additional research testing, the models contained in Section XI are regularly reviewed and updated to ensure their applicability, accuracy, and reflection of the latest known material behaviors. This improved knowledge may lead to more conservative models for crack growth over time. To accommodate such situations, Section XI has adopted an approach to conservatively account for potential increases in crack growth predictions with augmented examinations. The rules of IWB-3600 require that augmented (additional) examinations must be performed at an accelerated pace for situations where a flaw indication was accepted by analytical evaluation. This rule also protects against NDE uncertainties at the location of interest.
The nomenclature used here will be identical to that used in Section XI; any nomenclature that is not present in Section XI will be explained as it appears.
This chapter has been updated using the 2019 Code edition.

History
Warren H. Bamford is the original author of this chapter and has since revised it for all of the subsequent editions including the current online edition.
ASME Piping Codes: B31.3 Process, B31.5 Refrigeration, B31.9 Building Services and ASME Standards for Piping: B31E Seismic Design, B31J Stress I-Factors, B31T Toughness Requirements
Authors: Meyer Jimmy E. , Vilminot Kristi A. 
Published: June 2023

Abstract
This chapter covers the ASME B31.3 Process Piping Code as well as some of the other books in the B31 series.

History
Charles Becht IV was the author of “Chapter 17” titled “B31.3 PROCESS PIPING” for the first-third editions. Chapter 17 of the third edition was revised in its entirety and renumbered as Chapter 36 in the fourth edition authored by Jimmy E. Meyer who enlarged the scope of the chapter to include additional ASME B31 Codes and Standards. Jimmy E. Meyer and Kristi A. Vilmont updated this chapter for the current edition.
ASME Section III Division 4 Fusion Energy Devices Code Rules
Authors: Sowder William K. 
Published: June 2023

Abstract
The specific application of fusion for the future is power generation since, via appropriate plant design, fusion offers the potential to be a clean alternative to nuclear fission. This chapter provides insight into the current and new approaches for fusion energy being used today. These include experimental facilities, new fusion construction projects, and the next-generation fusion facilities. Within the ASME Section III organizational structure there is a Sub-Group “Fusion Energy Devices” (FED), whose charter is to develop the rules for the construction of fusion components. The fusion code rule development is focused on two basic Fusion Device Concepts: Magnetic Confinement Fusion (MCF) (the Tokamak) and Inertial Confinement Fusion, which is primarily laser fusion. The major systems that can make up a typical Tokamak system may include magnets (TF coils, PF coils, central solenoid coils, corrections coils, etc.), target chamber, vacuum vessel, in-vessel coil systems, in-vessel components (such as blanket, divertor, etc.), cryostat, vacuum vessel (VV) over-pressure suppression system, thermal shields, and machine support structure. In order to efficiently develop these new fusion code rules, a Division 4 Fusion Energy Device Roadmap was developed to guide in the development of these Fusion Energy Device Code Rules. This roadmap will help focus committee resources on all areas of the proposed new rules for development, as well as providing project management to this development effort. A phased approach is being used to develop the FED Codes Rules, which includes activities related to developing the direction and concepts for the new Section III, Division 4 Code Rules.