bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of high‐risk HPV other than type 16/18 in high‐grade cervical neoplasia among cytology‐negative women: A multicenter retrospective study
Authors: Bai Anying , Xue Peng , Li Qing , Jiang Yu , Qiao Youlin 
Published: May 2023

AbstractBackgroundHuman papillomavirus (HPV) is a necessary cause of cervical cancer, and a tool more sensitive than cytology for the early screening of cervical precancers. The two most carcinogenic genotypes HPV 16/18 have been reported in the majority of studies. High‐risk HPVs other than HPV 16/18 (non‐16/18‐hrHPVs) cause approximately a quarter of cervical cancers, and we aimed to analyze the genotype‐specific prevalence, risk and diagnostic efficiency of non‐16/18‐hrHPVs in cervical carcinogenesis among Chinese cytology‐negative women.MethodsA total of 7043 females who had abnormal cervical testing results from January 2018 to October 2021 were enrolled, among them 3091 were cytology‐negative. Descriptive statistics was used to estimate the HPV genotype‐specific prevalence, and multivariable logistic regression was used to estimate the genotype‐specific non‐16/18 hrHPVs risk of cervical carcinogenesis. The evaluation of diagnostic value among HPV genotypes included the possibility of predicting cervical intraepithelial neoplasia grade 2/3 or worse (CIN2+/CIN3+) and the diagnostic efficiency measured by increased referral rate and referral numbers of colposcopies per additional CIN2+/CIN3+ detected.ResultsAmong HPV‐positive cytology‐negative women, the five dominant genotypes for CIN2+/CIN3+ were HPV 31/33/35/52/58. HPV 52/58/33 had comparatively high sensitivity and specificity in predicting CIN2+/CIN3+, while the referral strategy of multiple HPV58 required 26 colposcopies to detect 1 CIN3+, compared with 14, 12, and 8 required by multiple HPV52, 31, and 33, respectively.ConclusionsHPV31/33/35/52/58 infections are significant risk factors for cervical lesions, and multiple HPV 31/33/52 infections should be included in the previously recommended HPV16/18 genotyping triage for colposcopy in China, as the benefits of disease prevention may outweigh the disadvantages of increasing requirements for colposcopy services.
Rituximab/bendamustine/cytarabine for transplant‐eligible patients with mantle cell lymphoma: A retrospective study
Authors: Shimizu Yuki , Kaji Daisuke , Watanabe Otoya , Yamaguchi Kyosuke , Kageyama Kosei , Taya Yuki , Nishida Aya , Ishiwata Kazuya , Takagi Shinsuke , Yamamoto Hisashi , Mori Yuki‐Asano , Wake Atsushi , Uchida Naoyuki , Taniguchi Shuichi , Yamamoto Go 
Published: May 2023

AbstractBackgroundMantle cell lymphoma is considered an aggressive B‐cell lymphoma. The optimal induction regimen remains controversial as no randomized controlled trial has compared the efficacy of different induction therapies.MethodHerein, we performed a retrospective analysis of the clinical characteristics of 10 patients who received induction treatment consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) and rituximab, bendamustine, and cytarabine (R‐BAC) at Toranomon Hospital between November 2016 and February 2022.ResultAlthough one patient discontinued R‐BAC therapy due to a rash, the other nine completed the scheduled chemotherapy. All patients achieved complete response, underwent high‐dose chemotherapy and autologous stem cell transplantation, and maintained complete remission with a median follow‐up of 15 months. Hematological adverse events (AEs) occurred in all patients; however, none developed documented infection. There were also no fatal non‐hematological AEs specific to R‐BAC.ConclusionR‐CHOP/R‐BAC may be a good induction therapy for transplant‐eligible patients with mantle cell lymphoma.
Foldamer Nanotubes Mediated Label‐Free Detection of Protein‐Small Molecule Interactions
Authors: Puneeth Kumar DRGKoppalu R. , Manzoor Bhat Zahid , Dey Sanjit , Roy Souvik , Panda Mahapatra Souvik , Pahan Saikat , Thotiyl Musthafa Ottakam , Gopi Hosahudya N. 
Published: May 2023

AbstractDevelopment of miniaturized lab‐on‐chip devices for the detection of rapid and specific small molecule‐protein binding interactions at very low concentrations holds significant importance in drug discovery and biomedical applications. Here, the label‐free detection of small molecule‐protein interactions is reported on the surface functionalizable nanotubes of α,γ‐hybrid peptide helical foldamers using nanoscale capacitance and impedance spectroscopy. The 12‐helix conformation of the α,γ‐hybrid peptide observed in the single crystals, self‐assembled into nanotubes in an aqueous environment with exposed cysteine thiols for small molecule conjugation. The binding of streptavidin to the covalently linked biotin on the surface of nanotubes was detected at the picomolar concentrations. No change in the capacitance and impedance were observed in the absence of either immobilized biotin or protein streptavidin. The functionalizable hybrid peptide nanotubes reported here pave the way for the label‐free detection of various small molecule protein interactions at very low concentrations.
Helical Self‐Assembly and Fe3+ Detection of V‐Shaped AIE‐Active Chiral Tetraphenylbutadiene‐Based Polyamides**
Authors: Zhao Zixuan , Zhang Lulu , Zhao Ying , Li Yanji , Shi Jianbing , Zhi Junge , Dong Yuping 
Published: May 2023

AbstractChiral aggregation‐induced emission (AIE) molecules have drawn attention for their helical self‐assembly and special optical properties. The helical self‐assembly of AIE‐active chiral non‐linear main‐chain polymers can produce some desired optical features. In this work, a series of V‐shaped chiral AIE‐active polyamides P1‐C3, P1‐C6, P1‐C12 and linear P2‐C3, P2‐C6, bearing n‐propyl/hexyl/dodecyl side‐chains, based on tetraphenylbutadiene (TPB), were prepared. All target main‐chain polymers exhibit distinct AIE characteristics. The polymer P1‐C6 with moderate length alkyl chains shows better AIE properties. The V‐shaped main‐chains and the chiral induction of (1R,2R)‐(+)‐1,2‐cyclohexanediamine in each repeating unit promote the polymer chains display helical conformation, and multiple helical polymer chains induce nano‐fibers helicity when the polymer chains aggregate and self‐assemble in THF/H2O mixtures. Simultaneously, the helical conformation polymer chains and helical nano‐fibers cause P1‐C6 produce strong circular dichroism (CD) signals with positive Cotton effect. Moreover, P1‐C6 could also occur fluorescence quenching response to Fe3+ selectively with a low detection limit of 3.48 μmol/L.
Sugar‐Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring
Authors: Jakšić Jovana , Solymosi Iris , Hirsch Andreas , Pérez‐Ojeda M. Eugenia , Mitrović Aleksandra , Maslak Veselin 
Published: May 2023

AbstractThe synthesis and characterization of four dumbbell‐shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron‐donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2⊃C60derivative. However, the methano‐dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono‐ and bis‐pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.
Long‐Lived Charge Separated States in Anthraquinone‐Phenothiazine Dyads: Synthesis and Study of the Photophysical Property by Using Transient Optical and Magnetic Resonance Spectroscopies
Authors: Wang Haiqing , Sukhanov Andrey A. , Iagatti Alessandro , Bussotti Laura , Zhao Xiaoyu , Zhao Jianzhang , Voronkova Violeta K. , Di Donato Mariangela 
Published: May 2023

AbstractIn order to obtain long‐lived charge separated (CS) states in electron donor‐acceptor dyads, herein we prepared a series of anthraquinone (AQ)‐phenothiazine (PTZ) dyads, with adamantane as the linker. UV–vis absorption spectra show negligible electronic interaction between the AQ and PTZ units at ground state, yet charge transfer (CT) emission bands were observed. Nanosecond transient absorption shows that the 3AQ state is populated upon photoexcitation for AQ‐PTZ in cyclohexane (CHX), but in acetonitrile (ACN) a 3CS state is formed. Similar results were observed for AQ‐PTZ‐M. The 3CS state lifetimes were determined as 0.52 μs and 0.49 μs, respectively. Upon oxidation of the PTZ unit, the 3AQ state was observed in both polar and non‐polar solvents. For AQ‐PTZ, femtosecond transient absorption spectra show fast formation of the 3AQ state in all solvents, with no charge separation in CHX, while formation of the 3CS state takes 106 ps in ACN. For AQ‐PTZ‐M, a 3CS state is formed in CHX within 241 ps. Time‐resolved electron paramagnetic resonance (TREPR) spectra show that a radical ion pair with electron exchange energy of |2 J|≥5.68 mT was observed for AQ‐PTZ and AQ‐PTZ‐M, whereas in the dyads with the PTZ unit oxidized, only the 3AQ state was observed.
Capture and Removal of Iodine by a Fluorinated Leaning Pillar[6]arene with Host–Guest Interactions
Authors: Shi Bingbing , Li Weichun , Qin Peng , Wei Tai‐Bao , Qu Wen‐Juan , Liu Yuezhou , Lin Qi 
Published: May 2023

AbstractVolatile radioactive pollutants are posing great challenges to global environment. Volatile radioactive iodine, which is one of the primary environmental pollutants from nuclear power plants, spreads rapidly in water and air and increases risk to human health. Therefore, the research for appropriate adsorbents to capture iodine with long‐term storage is crucial. In this study, we report that easily obtained fluorinated leaning pillar[6]areneFP6is a new adsorbent for iodine capture with robust moisture and thermal stability. Crystalline solidFP6solid can capture not only volatile iodine in the air but also iodine dissolved in aqueous solutions with fast adsorption speed and high up‐take capacity. Host–guest interactions betweenFP6and iodine indicates that iodine molecule is threaded into the cavity of the cyclic hostFP6to form a host‐guest complex driven by C−F ⋅⋅⋅ I halogen bonding interactions. Moreover, the regeneration ofFP6is simple and efficient, and it can be regenerated at least five times by simply heating under vacuum at 120 °C for 3 hours without losing iodine capture capacity. The excellent iodine pollutant removal ability demonstrates the promise ofFP6for pollutant treatment.
BiVO4 Heterojunctions as Efficient Photoanodes for Photoelectrochemical Water Oxidation
Authors: He Dongqing , Wang Qi , Zhang Weijun , Liu Xiaodong , Cui Xianghong 
Published: May 2023

AbstractPhotoelectrochemical (PEC) water splitting has attracted strong interest as sustainable technology by converting solar energy into hydrogen. The semiconductor photoelectrodes play an important role to increase the solar‐to‐hydrogen conversion efficiency. Bismuth vanadate (BiVO4) is an excellent candidate as a photoanode material for PEC water oxidation because of its visible light absorption, suitable band edge location, high stability and low cost. However, BiVO4 alone may undergo short carrier diffusion length, rapid recombination of photo‐induced charge carriers and photocorrosion. The heterojunction strategy established by combining two or more materials has provided an outstanding technique to address these issues. This Review focuses on recent important works with respect to BiVO4 heterojunction photoanodes for PEC water oxidation reactions, including interface junction and surface functional junction formation. Additionally, challenges faced and prospects for future research on BiVO4 heterojunction photoanodes in the field of solar‐to‐hydrogen conversion are proposed.
Insights into the Response Differences of Ultrasonic Rolled A3 Carbon Steels and 316L Stainless Steels to Scale and Wax Precipitation Behavior
Authors: Xue Juanqin , Ren Kang , Tao Guanyu , Tang Changbin , Guo Yinyin , Yu Yongqi 
Published: May 2023

AbstractIn this work, the antiscaling and antiwaxing properties are evaluated by surface roughness testing, water contact angle measurements, scale and wax deposition testing, and potentiodynamic polarization analysis, respectively. The morphologies and microstructures of the samples before and after ultrasonic surface rolling process (USRP) are analyzed by scanning electron microscopy and optical microscopy, respectively. The results show that for 316L stainless steel after USRP, its surface roughness and surface energy decrease by 97% and 27%, respectively, and the average scale amount is decreased by 73% and antiwaxing rate is up to 63%. In contrast, for the A3 steel after USRP, the average amount of scale and wax deposition increases due to the enhanced atomic activity of the surface layer and surface energy although its reduced surface roughness. It is found that the lower surface energy is the primary factor for improving the antiscaling and antiwaxing performance. A second factor may be related to the smooth surface and superior corrosion resistance.
Corporate social responsibility and technological perspectives in healthcare: An exploratory analysis of the evolution of the anti‐corruption system through multiple case studies
Authors: Campra Maura , Esposito Paolo , Brescia Valerio 
Published: May 2023

AbstractCorruption is one of the main variables to be considered in corporate social responsibility (CSR) to guarantee the well‐being of society in the long term. Information technology (IT) is able to reduce this phenomenon of corruption. However, no practical studies highlight the real effect on health organisations. This study ascertains the impact of a pilot project to prevent corruption and the introduction of new dedicated technologies in the healthcare organisation. It uses the association of institutional theory, information and communications technology (ICT), and new technologies to cover the gap and highlight the effect of an anti‐corruption pilot project of International Transparency Italia in the healthcare sector. A longitudinal approach‐based interventionist approach, coding of semi‐structured open interviews and corporate anti‐corruption plans using AltasIT from the 13 Health Organisations that joined the pilot project over a long term reveals that a positive effect spreads by mimetic approach within organisations. The study has detected open‐access databases, changes in personnel and procurement management approach, information dissemination, citizen involvement and whistleblowing support change through technologies. More specifically, it examines the evolution of the anti‐corruption system and the stakeholders' perceptions in healthcare organisations as a new form of social responsibility. To the best of our knowledge, this study is the only one that applies this perspective to the analysis of the anti‐corruption process through CSR currently underway in healthcare institutions worldwide.
Environmental backgrounds of CEOs and corporate environmental management information disclosure: The mediating effects of financing constraints and media attention
Authors: Zhu Changchun , Li Na , Ma Jing 
Published: May 2023

AbstractIn the context of the global economy's green and low‐carbon development, companies are paying increasing attention to environmental management. This study compiles statistics on Chinese listed firms from 2010 to 2020 and examines the influence of CEOs' environmental background on corporate environmental management information disclosure based on imprinting theory. It found that CEOs with environmental backgrounds are more willing to disclose corporate environmental management information, and the level of disclosure is high. By attracting media attention and reducing the company's financing constraints, CEOs with an environmental background can enhance the level of corporate environmental management information disclosure, according to the analysis of the impact mechanism. Further research revealed that CEO environmental background promoted corporate environmental management information disclosure more significantly in state‐owned and heavily polluting enterprises.
Epstein–Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism
Authors: Thomas Olivia G , Rickinson Alan , Palendira Umaimainthan 
Published: May 2023

AbstractThe link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled researchers since it was first discovered over 40 years ago. Until that point, EBV was primarily viewed as a cancer‐causing agent, but the culmination of evidence now shows that EBV has a pivotal role in development of MS. Early MS disease is characterised by episodic neuroinflammation and focal lesions in the central nervous system (CNS) that over time develop into progressive neurodegeneration and disability. Risk of MS is vanishingly low in EBV seronegative individuals, history of infectious mononucleosis (acute symptomatic primary infection with EBV) significantly increases risk and elevated antibody titres directed against EBV antigens are well‐characterised in patients. However, the underlying mechanism – or mechanisms – responsible for this interplay remains to be fully elucidated; how does EBV‐induced immune dysregulation either trigger or drive MS in susceptible individuals? Furthermore, deep understanding of virological and immunological events during primary infection and long‐term persistence in B cells will help to answer the many questions that remain regarding MS pathogenesis. This review discusses the current evidence and mechanisms surrounding EBV and MS, which have important implications for the future of MS therapies and prevention.
Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC
Authors: Metra Marco , Adamo Marianna , Tomasoni Daniela , Mebazaa Alexandre , Bayes‐Genis Antoni , Abdelhamid Magdy , Adamopoulos Stamatis , Anker Stefan D. , Bauersachs Johann , Belenkov Yuri , Böhm Michael , Gal Tuvia Ben , Butler Javed , Cohen‐Solal Alain , Filippatos Gerasimos , Gustafsson Finn , Hill Loreena , Jaarsma Tiny , Jankowska Ewa A. , Lainscak Mitja , Lopatin Yuri , Lund Lars H. , McDonagh Theresa , Milicic Davor , Moura Brenda , Mullens Wilfried , Piepoli Massimo , Polovina Marija , Ponikowski Piotr , Rakisheva Amina , Ristic Arsen , Savarese Gianluigi , Seferovic Petar , Sharma Rajan , Thum Thomas , Tocchetti Carlo G. , Van Linthout Sophie , Vitale Cristiana , Von Haehling Stephan , Volterrani Maurizio , Coats Andrew J.S. , Chioncel Ovidiu , Rosano Giuseppe 
Published: May 2023

AbstractAcute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post‐discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre‐discharge and titration to target doses in the early post‐discharge period, of guideline‐directed medical therapy may improve both short‐ and long‐term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre‐discharge and the early post‐discharge phase after a hospitalization for acute heart failure.
A theoretical evaluation of the impact of the type of reaction on heat production and material losses in biomass piles
Authors: Dahlbom Sixten , Anerud Erik , Lönnermark Anders , Pushp Mohit 
Published: May 2023

AbstractSelf‐heating during storage of biomass in piles causes material losses, leads to emissions to air, and poses a risk of fire. There are different techniques to assess a biomass material's propensity for self‐heating, some of these are briefly reviewed. One of these techniques is isothermal calorimetry, which measures thermal power from materials and produces time‐resolved curves. A recently developed and published test standard, ISO 20049‐1:2020, describes how the self‐heating of pelletized biofuels can be determined by means of isothermal calorimetry and how thermal power and the total heat produced during the test should be measured by isothermal calorimetry. This paper supports interpretation of the result obtained by isothermal calorimetry; the mentioned standard provides examples of peak thermal power and total heat but does not provide any assistance on how the result from isothermal measurements should be interpreted or how the result from measurements on different samples could be compared. This paper addresses the impact of different types of reactions, peak thermal power, total heat released (heat of reaction), activation energy, heat conductivity, and pile size on the temperature development in a generic pile of biomass. This paper addresses important parameters when the result from isothermal calorimetry is evaluated. The most important parameter, with respect to temperature development in large piles, was found to be the total heat released. It was also proposed that safe storage times, that is, the time until a run‐away of the temperature in the pile, could be ranked based on the time to the peak thermal power.
Optimizing the effect of plant protease on different properties of analog cheese containing functional corn leachate
Authors: Araghi Farideh Eslambeig , Nodushan Rezvan Mousavi , Jafarpour Afshin , Moslehishad Maryam 
Published: May 2023

AbstractCheese is produced in different flavors, textures, and forms by coagulating the milk protein casein. This study investigated the possibility of producing analog cheese by using corn steep liquor with Withania coagulans extract (WCE) and adding Eryngium planum extract (EPE) and Origanum majorana extract (OME) as functional ingredients. Different physicochemical, microbial, texture, and sensory properties of the samples were evaluated. The results obtained for moisture factor, fat, ash, water content, L*, b*, firmness, overall form, Lactobacillus and overall acceptance of the effect of all three process variables, pH, and acidity show that only the effect of WCE and OME is significant. Also, the protein of the samples was significant only on WCE and EPE (p < .001). The results showed that an increase in the levels of independent variables resulted in an increase in the amount of moisture, ash, protein, Lactobacillus, and b* and a decrease in fat, syneresis, texture properties, coliform, and lightness. Evaluation of the overall acceptance showed that consumer acceptance increased with the increase in WCE, but it initially increased and then decreased with the increase in EPE and OME levels. Finally, the samples containing 1.5% WCE, 1% EPE, and 0.5% OME were chosen as the optimized ones.