bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE ACECLOFENAC SUPPOSITORY
Authors: Baria A. H. , Patel R. P. , Suthar A. M , Parmar R. B 
Published: January 2025

The aim of this study was to prepare sustained release (SR) suppositories containing Aceclofenac microspheres. In the first part of the study, Aceclofenac microspheres were prepared by solvent evaporation method employing ethyl cellulose as a microsphere forming polymer. The effect of drug: polymer ratio and stirring rate on microspheres formation, average particle size, incorporation efficiency, micromeritic properties and in vitro Aceclofenac release were investigated. The highest drug loading capacity was found with 1:1 drug- polymer ratio stirring rate caused insignificant effect on drug loading capacity. In the second part, SR suppositories were formulated by incorporating Aceclofenac microspheres having the highest drug loaded. The bases used were PEG 4000, PEG 6000 and stearic acid. The drugs released were evaluated by in vitro dissolution tests. Comparative results of SR suppositories containing Aceclofenac microspheres with that of conventional ones showed that the former has sustained effect up to 8 h in vitro.
PHARMACOLOGICAL ACTIVITIES OF ‘CHANDRAKHYA’ LEAVES
Authors: Singhai Ashish , Singour P. K. , Pawar R. S. , Patil U. K. 
Published: January 2025

A simple, precise and reproducible reverse phase, isocratic high performance liquid chromatographic method was developed and validated for the quantitative determination of sodium valproate in bulk and enteric coated tablet dosage form. The quantification was carried out using a Nova-pack phenyl, 4µm, 150 mm × 3.9 mm i.d. column, with a mobile phase consisting of acetonitrile: buffer (30:70, v/v) (pH 2.5) at a flow rate of 1.2 ml/min and UV detection at 210 nm. The method was validated for specificity, linearity, accuracy, precision, limit of detection, limit of quantification, robustness and solution stability. The linearity of the proposed method was investigated in the range of 50-1500 µg/ml (r = 0.9999). Mean inter- and intra-assay relative standard deviations (RSD) were less than 2.0 %. The proposed method was successfully applied for the analysis of sodium valproate in bulk and pharmaceutical dosage forms. Also, the method was extended for determination of sodium valproate release from in-vitro dissolution studies.
FORMULATION AND EVALUATION OF NEOMYCIN SULPHATE OINTMENT CONTAINING NATURAL WOUND HEALING AGENT CURCUMA LONGA
Authors: D Akanksha , G Vikas , K. J Neetesh , S Shailendra , B Neelam , K. J Dinesh 
Published: January 2025

Present investigation was to develop novel ointment formulation in combination of natural wound healing agent curcuma longa, which is reported to possess wound healing and anti-bacterial activities. Combination of neomycin sulphate and curcuma longa is good rational, where curcuma longa produces synergistic wound healing effect with neomycin sulphate. Formulations containing fixed concentration (0.5 %) of neomycin sulphate and 3 %, 4 % and 5 % of curcuma longa were prepared. To assess the efficacy of formulations anti-bacterial activity, rheology, stability, spreadability and other physical characteristics were evaluated. The results obtained were encouraging and formulation containing neomycin sulphate (0.5 %) with 5 % of curcuma longa was found better than other formulations.
ANTIOXIDANT ACTIVITY OF THE SUCCESSIVE EXTRACTS OF AESCULUS INDICA LEAVES
Authors: Chakraborthy Guno Sindhu 
Published: January 2025

Plants are the best source of active secondary metabolites which are beneficial to mankind. Many plant origin drugs have been reported with biological properties like Analgesic, Anti-inflammatory, Antioxidant, hypoglycemic agents and many more. The successive extracts of Aesculus indica leaves were screened for in vitro antioxidant properties using the standard procedures. The successive extracts such as petroleum ether, ethyl acetate, methanol and water and 50% crude methanol extracts exhibited IC 50 values of respectively in DPPH and respectively in nitric oxide radical inhibition assays. The values are comparable with the standards such as ascorbic acid and quercetin. The Aesculus indica leaves are showing significant antioxidant activity.
QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIP USING ARTIFICIAL NEURAL NETWORK: A REVIEW
Authors: Singh S. K. , Saini Sangita , Verma Bharat , Mishra D. N. 
Published: January 2025

Quantitative structure activity relationship (QSAR) has become a tool for designing in various areas like drugs, food additive, Pesticides, biochemical reactant, environmental pollutant and toxic products. In QSAR biological activity can be related with physicochemical properties and in QSPkR (Quantitative Structure Pharmacokinetic Relationship), pharmacokinetic properties can be related with physicochemical properties, relation found in terms of quantity. A number of literature and review article have been published on Quantitative structure pharmacokinetic relationship. But prediction of human pharmacokinetic properties of known and unknown is much difficult job in pharmaceutical industry. Pharmacokinetic data of animal cannot be put straightforward. Artificial neural network (ANN) is used to predict the pharmacokinetic properties. Artificial neural network has basic structure like biological brain and compose of neurons which are interconnected to each other. The present review not only compiles the literature of QSPkR using ANN, but gives detail about the physicochemical properties and artificial neural network.
Aquaculture Wastewater Treatment by Constructed Wetlands Planted with Anthurium Plants (Anthurium andraeanum)
Authors: Phuong Nguyen Minh , Kha Tran Minh , Anh Bui Thi Kim 
Published: January 2025

Aquaculture wastewater often has high content of organic matter and nutrients (nitrogen, phosphorus). Along with the rapid development of the aquaculture industry is the problem of water pollution, eutrophication... because of untreated wastewater. Among current wastewater treatment methods, constructed wetland technology is an environmentally friendly wastewater treatment solution, providing high treatment efficiency and low cost. In this study, constructed wetland systems planted with anthurium plants (Anthurium andraeanum) at laboratory-scale were established to treat shrimp farming wastewater in Quang Ninh. The results showed that after 15 experimental days, the wetland system planted with anthurium plants on gravel and coconut fiber materials had organic matter (COD) removal efficiency, ammonium (NH4+-N) and phosphate (PO43--P) removal efficiency of 87.5%, 76% and 44.1%, respectively. The wetland system planted with anthurium plants on gravel had organic matter (COD) removal efficiency, NH4+-N and PO43--P removal efficiency of 75.7%, 46.7%, and 40.6%, respectively. Meanwhile, the COD removal efficiency, NH4+-N and PO43--P removal efficiencies in the control system were only 15.8%, 12.6% and 19.4%, respectively. The research results show the ability of constructed wetland systems planted with anthurium plants to treat aquaculture wastewater.
ИСПОЛЬЗОВАНИЕ МИКРОПАРТИКУЛЯТА СЫВОРОТОЧНЫХ БЕЛКОВ В МОРОЖЕНОМ С НИЗКИМ СОДЕРЖАНИЕМ СОМО
Authors: Ландиховская Анна Валентиновна , Творогова Антонина Анатольевна , Кочнева Светлана Евгеньевна 
Published: January 2025

Для восполнения дефицита белка в рационе питания необходимо производство продуктов с повышенным его содержанием. Важными источниками белка являются побочные продукты переработки сыворотки и обезжиренного молока в виде концентрированных форм. Целью исследований являлось изучение показателей качества мороженого с низким содержанием жира и сухого обезжиренного молочного остатка при дополнительном введении сывороточного белка в виде микропартикулята. Установлено, что при увеличении содержания белка за счет микропартикулята сывороточных белков в 1,2 раза в мороженом с низким содержанием сухих обезжиренных веществ молока (3 %) при массовой доле жира (1 %) достигаются технологически значимые показатели качества продукта с содержанием жира 4 %. Однако по показателю «условная твердость» (10Н) такое мороженое уступало контрольному. При повышении содержания белка в мороженом в 1,8 раза до уровня 6 % значение условной твердости составляло 5,8H и не имело значимых различий с контрольным образцом. Титруемая кислотность в образце с наибольшим содержанием белка (6 %) достигала уровня традиционного продукта, динамическая вязкость была больше в 1,5 раза, улучшалась дисперсность кристаллов льда. Но при этом формировались наиболее крупные воздушные пузырьки со средним размером 41 мкм, в контроле ‒ 35 мкм. По результатам органолептической оценки образцов установлено положительное влияние повышенного содержания микропартикулятов сывороточных белков на консистенцию мороженого. Установлена необходимость использования пищевкусовых добавок для нивелирования влияния низкого содержания сухих обезжиренных веществ молока на вкус продукта. С учетом технологически значимых показателей качества мороженое с низким содержанием сухих обезжиренных веществ молока при дополнительном введении микропартикулята сывороточных белков можно производить на действующих предприятиях отрасли с целью расширения ассортимента продукции функциональной направленности.
СТОЙКОСТЬ ПРИ ХРАНЕНИИ МУКИ ИЗ СОРГО, ПОЛУЧЕННОЙ РАЗНЫМИ СПОСОБАМИ
Authors: Анисимова Людмила Витальевна , Серебреникова Екатерина Сергеевна , Гергерт Екатерина Олеговна , Гузий Данил Юрьевич 
Published: January 2025

Изучено влияние способа получения сорговой муки на стойкость при хранении, которую оценивали по влажности, кислотности по болтушке и кислотности по водно-спиртовой вытяжке. Исследованы следующие способы возможного повышения стойкости муки при хранении: частичное удаление оболочек и зародыша при шелушении-шлифовании зерна и проведение гидротермической обработки (ГТО) зерна сорго при подготовке его к шелушению. При этом применяли два способа ГТО: с интенсивным увлажнением под вакуумом, отволаживанием и сушкой зерна и с пропариванием и сушкой зерна. Кроме того, вырабатывали муку из зерна сорго, не подвергавшегося ГТО и не прошедшего операцию шелушения-шлифования (цельнозерновую). Зерно и ядро измельчали на лабораторной молотковой мельнице со встроенным ситом № 08. Свежесмолотую сорговую муку направляли на хранение при относительной влажности воздуха 65±0,1 % и температуре 20±0,5 и 40±1 ºC. Муку хранили в текстильных (хлопковых) мешках и полиэтиленовых пакетах. Установлено, что способ получения сорговой муки практически не оказал влияния на равновесную влажность муки из голозерного сорго, хранившейся при постоянной температуре; включение в технологическую схему подготовки сорго к измельчению операций шелушения-шлифования и гидротермической обработки зерна стабилизировало свойства сорговой муки при хранении: замедлился рост титруемой кислотности как по болтушке, так и по водно-спиртовой вытяжке; лучшая стойкость при хранении по исследованным показателям качества отмечена у муки из голозерного сорго, прошедшего ГТО с пропариванием, затем следует сорговая мука из зерна, прошедшего ГТО с интенсивным увлажнением под вакуумом, далее – сорговая мука из шелушеного, но не подвергнутого ГТО зерна; наименьшую стойкость при хранении имела цельнозерновая сорговая мука; упаковка в полиэтиленовые пакеты показала лучшую сохранность сорговой муки по сравнению с упаковкой в тканевые мешки.
Учитель императора и его наследие. Материалы А.Б. Кеммерера в коллекции Минералогического музея им. А.Е. Ферсмана
Authors: Генералов М.Е. , Агаханов А.А. 
Published: January 2025

Один из авторов образцов Музея, Александр Богданович (Август-Александр) Кеммерер, оставил заметный след в отечественной минералогии и горном деле. Он изучал ряд минералогических находок, работал с разными минералогическими собраниями, в том числе позднее попавшими в коллекцию Минералогического музея, под его влиянием ряд минералов получил названия в честь российских государственных деятелей. Образцы с его авторством, присутствующие в коллекции, интересны как примеры ранних находок ряда минералов. Образцы платиноидов из его собрания связаны с открытием первых богатых платиновых россыпей из района Нижнетагильского дунит-гарцбургитового массива. Изучена минералогия этих материалов, показано разнообразие форм распада твердых растворов железистой платины. Сделан вывод о связи изученного вещества преимущественно с высокотемпературной ассоциацией минералов платиноидов Нижнетагильского массива, с выработанными к настоящему времени делювиально-пролювиальными россыпями.
One of the authors of the Museum samples, Alexander Bogdanovich (August-Alexander) Kaemmerer left a noticeable mark on Russian mineralogy and mining. He studied a number of mineralogical finds, worked with various mineralogical collections, including those that later were included to the collection of the Mineralogical Museum. Under his influence, a number of minerals were named in honor of Russian statesmen. The samples with his authorship in the Museum collection are examples of early finds of a number of minerals in Russia. Samples of platinum group minerals from his collection are associated with the discovery of the first rich platinum placers from the area of the Nizhny Tagil dunite-harzburgite massif. The mineralogy of these materials was studied, and a variety of forms of decomposition of solid solutions of ferrous platinum were shown. A conclusion was made about the connection of the studied substance, mainly, with the high-temperature association of platinum group minerals of the Nizhny Tagil massif, with the deluvial-proluvial placers that have been exhausted.
The Participation Level of The Local Community towards Community-Based Tourism Development in Sopapei Tourism Destination, Ambon, Indonesia
Authors: Wawo Mintje , Tetelepta Johannes M.S. , Willem Ayal Frederik , A.B Mamesah Juliaeta , Rahman  , Bernard Hehakaya Trealy 
Published: January 2025

Community-based tourism is owned and managed by the community and intended to deliver wider community livelihood benefits. Sopapei Beach is one of the tourist destination spots in Ambon, and it is visited mostly by local tourists. This area has six tourism spots, all managed by individual local communities. This study aimed to investigate the potency of developing community-based tourism in this area. The study was conducted between July – September 2023. Descriptive statistical analysis was used in this study. An interview, field observation, and literature review were used to obtain information on tourism activity and mechanisms in Sopapei Beach. A purposive sampling method was used to collect the informant to be interviewed. The SWOT analysis was used to develop strategy management for community-based tourism (CBT) development possibilities. The result shows that most informants claim that Sopapei is an attractive tourist spot with a fascinating marine view, a friendly atmosphere, a nice beach, and attractive culinary dishes. There was a small probability of conflict potency between the local tourism owners. The CBT management approach was a possibility to reduce the conflict potency. Participatory of the local community in the local community in tourism was considered fair. SWOT analysis proposes 13 management strategies for developing CBT in Sopapei Beach.
Perpustakaan Bait Al-Hikmah dan Kontribusinya Terhadap Perkembangan Peradaban Dunia
Authors: Rahman Bobbi Aidi , Yonifia Ismi 
Published: January 2025

Dalam sejarah peradaban Islam, pencapaian yang luar biasa terutama dalam pengembangan ilmu pengetahuan terjadi pada masa Dinasti ‘Abbasiyah. Perkembangan ilmu pengetahuan dan teknologi pada masa ini tidak terlepas dari perhatian dan dorongan dari para khalifah dengan memberikan wadah atau tempat, seperti Bait al-Hikmah dan memberikan imbalan yang sesuai sebagai bentuk motivasi dan apresiasi terhadap karya-karya ilmuwan Muslim. Dalam tulisan ini penulis akan membahas sejauhmana fungsi dan peran serta kontribusi Bait al-Hikmah dalam pengembangan ilmu pengetahuan dan teknologi terhadap peradaban dunia, terutama pada masa tiga khalifah, yakni Abu Ja’far al-Mansur, Harun al-Rasyid, dan al-Ma’mun. Adapun metode yang digunakan dalam tulisan ini adalah metode sejarah dengan meliputi empat tahapan, yakni heuristik, verifikasi, interpretasi dan historiografi. Tulisan ini menyimpulkan bahwa fungsi dari Bait al-Hikmah tidak saja hanya sebagai perpustakaan, tetapi juga sebagai pusat penerjemahan, pendidikan serta penelitian. Sedangkan peran Bait al-Hikmah pertama, sebagai wadah dalam pengembangan ilmu pengetahuan, kedua, pembentukan pola pikir, dan yang ketiga, sebagai tempat akulturasi berbagai budaya. Adapun kontribusi Bait al-Hikmah ini lahirnya ilmuwan-ilmuwan Muslim yang mendunia dan memiliki kepakaran dalam berbagai bidang yang menjadi cikal bakal ide dan gagasan bagi ilmuwan Barat saat ini.
What Is Digital Communication? Developing a Conceptual Definition of the Term
Authors: El-Astal Mohammed , El-Youssef Hala 
Published: January 2025

This inductive paper seeks to develop a conceptual definition of the term ‘digital communication,’ enriching the literature that lacks a definition. To that end, the authors collected twenty-five manifestations, or insufficient fragmented pieces of knowledge, from the literature, employing the theme-rheme concept to analyze the manifestations collected and (employing the same formula) to condense and synthesize the themes and rhemes found in a working conceptual definition of the term. The ‘theme-rheme’ concept proposed for analysis and synthesis was utilized from Halliday’s Systemic Functional Linguistics (SFL). Based on the analyses of the manifestations collected, this paper defines digital communication as the process through which a source, using an interactive channel, sends a purposive, binarily programmed, greased, measurable, widely accessible, and retrievable message to a destination that has unlimited opportunity to provide feedback. The working definition developed here is expected to delineate the scope of digital communication and deepen the understanding of the term among theorists, practitioners, researchers, instructors, and students. Ontologically, delineating the scope of digital communication clarifies what falls within it as a field of study and what lies outside. In addition, the definition paves the way for developing a model for digital communication (in which the message is socially and cross-culturally constructed) and courses for teaching it.
Influence of Determinant Factors on Safety Behavior for Infusion Installation in Emergency Room Nurses
Authors: Dwi Ochta Pebriyanti  
Published: January 2025

Pendahuluan: Rumah Sakit sebagai tempat kerja yang unik dan kompleks, dengan potensi bahaya kesehatan dan keselamatan kerja tidak dapat dihindari seperti tertusuk jarum bekas pasien. Healthcare Associated (HAIs) merupakan salah satu risiko yang dihadapi oleh tenaga kesehatan dan banyak terjadi di seluruh dunia dengan kejadian terbanyak di Negara miskin dan Negara berkembang, WHO menunjukkan sekitar 8,7% dari 55 rumah sakit di 14 negara di Eropa, Timur Tengah, dan Asia Tenggara dan Pasifik terjadi HAIs. Tingkat pengetahuan dan motivasi keselamatan kerja yang paling kuat terkait dengan perilaku keselamatan kerja. Tujuan: penelitian ini bertujuan untuk menganalisis pengaruh faktor determinan terhadap safety behavior pemasangan infus pada perawat di IGD RSUD Dr. Haryoto Lumajang. Metode: penelitian ini menggunakan metode penelitian kuantitatif dengan desain penelitian cross sectional, teknik pengambilan sampel yaitu total sampling sejumlah 21 orang. Hasil: Berdasarkan hasil uji regresi linier terdapat pengaruh jenis kelamin (nilai sig. 0,004), masa kerja (nilai sig. 0,031) dan pelatihan/sosialisasi K3 (nilai sig. 0,004) terhadap safety behavior tindakan pemasangan infus. Kesimpulan: tuntutan pekerjaan sebagai seorang perawat terutama di IGD yang merupakan pintu pertama pasien masuk, dimana keselamatan pasien yang diutamakan terkadang menuntut perawat bekerja dengan tidak aman.
Kata kunci: tingkat_pengetahuan, motivasi_Keselamatan Kerja, pemasangan_infus
Peningkatan Kemampuan Sosial Melalui Permainan Outdoor Pada Anak Usia 5-6 Tahun
Authors: Anisa Nurul , Sit Masganti 
Published: January 2025

Memberikan pengalaman sosial awal dalam pendidikan menjadi tugas guru ketika berada di sekolah dan menjadi tugas orang tua ketika berada di rumah. Penelitian ini bertujuan untuk meningkatkan kemampuan sosial melalui permainan outdoor pada anak usia 5-6 tahun TK Nurul Ihsan Ilmi Jl. Gambir Pasar VIII Tembung. Penelitian ini menggunakan penelitian tindakan kelas. Metode pengumpulan data dilakukan dengan observasi dan dokumentasi. Subjek dalam penelitian ini anak usia 5-6 tahun yang dengan jumlah peserta didik yaitu 15 anak yang terdiri dari 9 peserta didik laki-laki dan 6 peserta didik perempuan. Hasil penelitian kemampuan sosial anak prasiklus terdapat 33,3%. Setelah dilakukan siklus I menunjukkan adanya peningkatan kemampuan sosial anak yaitu terdapat 45,56% dan pada siklus II kemampuan sosial anak menjadi 89,56%. Dapat disimpulkan bahwa melalui permainan outdoor dapat meningkatkan kemampuan sosial anak usia 5-6 tahun di TK Nurul Ihsan.
Implementasi Manajemen Ekstrakurikuler Tari dalam Pembentukan Karakter Nasionalisme
Authors: Nurbani Rizkia Ramadhania , Fitriani Yulianti , Arzaqi Roby Naufal 
Published: January 2025

Penelitian ini dilatarbelakangi oleh pentingnya karakter nasionalisme yang harus ditanamkan sejak dini pada anak sebagai dasar karakter bangsa. Fokus penelitian ini adalah implementasi manajemen ekstrakurikuler tari dalam pembentukan karakter nasionalisme di TK Islam Widya Cendekia. Penelitian ini bertujuan untuk mengeksplorasi manajerial perencanaan, pengorganisasian, pelaksanaan, dan pengawasan dalam kegiatan ekstrakurikuler tari, serta bagaimana kegiatan tersebut memfasilitasi pembentukan karakter nasionalisme pada siswa. Menggunakan pendekatan kualitatif dengan metode deskriptif, teknik pengumpulan data meliputi observasi partisipatif, wawancara semi-terstruktur, dan analisis dokumen. Hasil penelitian menunjukkan bahwa manajemen ekstrakurikuler tari yang efektif anak-anak akan menjadi pribadi yang demokratis, memiliki semangat kebangsaan, memiliki rasa cinta tanah air dan memiliki sikap berkebhinekaan global. Penelitian ini dapat dimanfaatkan oleh guru dan sekolah sebagai bahan pengembangan nilai-nilai karakter pendidikan, terutama karakter nasionalisme, yang diperoleh melalui aktivitas ekstrakurikuler tari.
الاستقامة التنظيمية لدى رؤساء الاقسام في كلية وأقسام التربية البدنية وعلوم الرياضة في جامعة الموصل من وجهة نظر ملاكتها التدريسية
Authors: عباس عبد السلام 
Published: January 2025

هدف البحث الى: اعداد استبيان الاستقامة التنظيمية في كلية واقسام التربية البدنية وعلومَ الرياضة في جامعة الموصل. والتعرف على مستوى الاستقامة التنظيمية في كلية واقسام التربية البدنية وعلوم الرياضة في جامعة الموصل. والتعرف على الفروق ذو الدلالة الاحصائية في الاستقامة التنظيمية في كلية واقسام التربية البدنية وعلوم الرياضة تبعاً لمتغير الجنس. والتعرف على الفروق ذو الدلالة الاحصائية في الاستقامة التنظيمية في كلية واقسام التربية البدنية وعلوم الرياضة تبعاً لمتغير الكلية أو القسم. استخدم الباحث المنهج الوصفي بالأسلوب المسحي والارتباطي، وتحدد مجتمع البحث بالهيئة التدريسية في كلية واقسام التربية البدنية وعلوم الرياضة في جامعة الموصل، والبالغ عددهم (157) تدريسي، وتمثل بنسبة (%100) من مجتمع البحث، اذ تم تحديهُ بأسلوب الحصر الشامل، اذا تم إجراء مقابلة شخصية مع مدير الموارد البشرية من اجل الحصول على البيانات، اما عينة البحث فقد كانت هي مجتمع البحث نفسهُ، اذ شملت على جميع التدريسيين.