bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is phased implementation of HPV testing and triage with dual staining the way to transform organized cytology screening?
Authors: Sláma Jiří , Dvořák Vladimír , Trnková Markéta , Skřivánek Aleš , Hrabcová Karolína , Ovesná Petra , Nováčková Martina 
Published: September 2023

Objective
The substantial material and legislative investments in establishing and maintaining cytological screening in the Czech Republic represent barriers to a direct transition to primary HPV screening. Therefore, the LIBUSE project was implemented to test the efficacy of phasing in HPV DNA testing as a co-test to cytology in routine screening of women >30 years of age.

Methods
Women aged 30 to 60 years who underwent regular annual Pap smears were co-tested for HPV DNA with selective 16/18 genotyping at 3-year intervals. All HPV 16/18-positive cases and/or cases with a severe abnormality in cytology were sent for colposcopy; HPV non-16/18-positive cases and LSILs were graded using p16/Ki67 dual-stain cytology, and positive cases were sent for colposcopy.

Results
Overall, 2409 patients were included. After the first combined screening (year ‘zero’) visit, 7.4% of women were HPV-positive and 2.0% were HPV16/18-positive; only 8 women had severe Pap smear abnormalities. Triage by dual staining was positive in 21.9% of cases (28/128). Biopsy confirmed 34 high-grade precancer lesions. At the second combined visit (year ‘three’), the frequency of HPV infection (5.3% vs. 7.4%) frequency of HPV16/18 (1.1% vs. 2.0%), referrals for colposcopy (35 vs. 83), and biopsy verified high-grade lesions (5 vs. 34) were significantly lower (all P ≤ 0.001).

Conclusion
The addition of HPV DNA testing with selective genotyping of HPV16/18 to existing cytology screening significantly increased the safety of the program. The gradual introduction of HPV testing was well received by healthcare professionals and patients, and can facilitate transformation of the cytology-based screening. ClinicalTrials.gov Identifier: NCT05578833.
Neoadjuvant Immunotherapy and Non–Small Cell Lung Cancer
Authors: Yu Shaofu , Zhai Shasha , Gong Qian , Xiang Chunhong , Gong Jianping , Wu Lin , Pu Xingxiang 
Published: September 2023

Objectives:
To systematically evaluate the effectiveness and safety of neoadjuvant immunotherapy for patients with non–small cell lung cancer (NSCLC).

Methods:
Randomized controlled trials of neoadjuvant immunotherapy in treating patients with NSCLC were comprehensively retrieved from electronic databases, eligible studies, previous systematic reviews and meta-analyses, guidelines, and conference abstracts. The meta-analysis was performed by the Stata/SE 12.0 software.

Results:
Eleven randomized controlled trials were eventually included. The results of the meta-analysis showed that neoadjuvant immunochemotherapy significantly improved the objective response rate compared with neoadjuvant chemotherapy (CT; 62.46% vs 41.88%, P = 0.003), but the objective response rate of neoadjuvant double-immunotherapy was roughly comparable to that of neoadjuvant single-immunotherapy (15.74% vs 10.45%, P = 0.387). Major pathologic response (MPR) rate and pathologic complete response (pCR) rate of neoadjuvant immunochemotherapy and neoadjuvant double-immunotherapy were significantly superior to neoadjuvant CT alone and neoadjuvant single-immunotherapy, respectively. Compared with neoadjuvant CT alone, neoadjuvant immunochemotherapy increased the down-staging rate (40.16% vs 26.70%, P = 0.060), the surgical resection rate (83.69% vs 73.07%, P = 0.231), and R0 resection rate (86.19% vs 77.98%, P = 0.502), but there were no statistically significant differences. Neoadjuvant immunochemotherapy did not increase the postoperative complications rate than neoadjuvant CT alone (40.20% vs 41.30%, P = 0.920). In terms of safety, neoadjuvant immunochemotherapy and neoadjuvant double-immunotherapy did not increase the incidence of treatment-related adverse events (TRAEs) and the grade 3 or higher TRAEs.

Conclusions:
In summary, neoadjuvant immunochemotherapy had better clinical efficacy than neoadjuvant CT for patients with NSCLC. MPR rate and pCR rate of neoadjuvant immunochemotherapy and neoadjuvant double-immunotherapy were significantly superior to neoadjuvant CT and neoadjuvant single-immunotherapy, respectively, for patients with NSCLC, showing that MPR rate and pCR rate were probably considered as alternative endpoints for survival benefit. TRAEs were comparable between the corresponding groups. The long-term survival outcome of neoadjuvant immunotherapy for patients with NSCLC needs to be further confirmed to better guide clinical practice.
Nurse-led speech therapist referral initiative for older adult patients at risk of dysphagia: a best practice implementation project
Authors: Khor Adeline Nyong Siew , Juay Westine Wei Lin , Wong Yi Yan , Omar Nur Elydia Binte , Liu Yajing , Kong Yingying , Goh Mien Li 
Published: September 2023

ABSTRACTIntroduction and objectives:Dysphagia is common among older patients, affecting their nutritional status, hospital readmission, length of hospital stay, and hospitalization costs. Nurses can play a key role in early identification of dysphagia through systematic screening. This project sought to (i) achieve 80% compliance among nurses in using the 4-point questionnaire test (4QT) swallow screening test on patients and (ii) ensure all patients screening positive for dysphagia were referred to a speech therapist within 1 day.Methods:A short swallow screening tool was adapted from an evidence-based screening tool, the 4QT, by a team of speech therapists, a geriatrician, and a geriatric trained nurse. Ward nurses were then trained on using the tool to screen older patients upon admission or transfer to another ward. The project used the JBI Evidence Implementation Framework, which involved pre and post audits and feedback to evaluate compliance with best practice.Results:Compliance increased in the use of the short swallow screening tool, rising from 64% (n = 25) in the baseline audit to 71% (n = 34) in the follow-up audit. However, there was a decrease in the referral of patients who screened positive for dysphagia to speech therapists, with the rate dropping from 92% (n = 12) to 86% (n = 12). All patients (n = 12) from both baseline and follow-up audits were referred to a speech therapist within 1 day of admission/transfer post-implementation compared with 70% (n = 7) at pre-implementation.Conclusions:This project applied evidence-based recommendations to clinical practice and improved patient outcomes. The nurses facilitated timely referrals to speech therapists for further assessment and intervention, which was useful in the clinical context. The nurses continue to use the screening tool routinely to prevent dysphagia complications among geriatric patients.
High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease
Authors: Chen Zhichun , Li Guanglu , Zhou Liche , Zhang Lina , Liu Jun 
Published: September 2023

AbstractBackgroundAnxiety is one of the most common psychiatric symptoms in Parkinson’s disease (PD). Whether anxiety shapes disease progression and brain network aberrations in PD remain largely unknown. The objective of present study is to investigate whether anxiety exacerbates clinical symptoms and brain network abnormalities of PD patients.MethodsPD patients performing magnetic resonance imaging from Parkinson’s Progression Markers Initiative (PPMI) database were specifically included. According to the scores of State-Trait Anxiety Inventory (STAI), PD patients were classified into lower quartile group (STAI score rank: 0%∼25%), interquartile group (STAI score rank: 26%∼75%), and upper quartile group (STAI score rank: 76%∼100%) based on their STAI score quartiles to investigate how anxiety affects clinical manifestations and brain networks.ResultsAnxiety was independently associated with both motor and non-motor symptoms of PD patients. Consistently, PD patients in the upper quartile group showed more severe non-motor symptoms compared to lower quartile group. Moreover, they also exhibited significantly different topological metrics in structural network compared to lower quartile group. Furthermore, we demonstrated that differential network metrics mediated the associations between anxiety and motor and non-motor symptoms of PD patients.ConclusionsPD patients with higher anxiety level exhibited more severe clinical manifestations and disruptions of brain network topology. Diverse structural network metrics were associated with motor and non-motor symptoms of PD patients.
Forecasting drug overdose mortality by age in the United States at the national and county levels
Authors: Böttcher Lucas , Chou Tom , D’Orsogna Maria R. 
Published: September 2023

The drug overdose crisis in the United States continues to intensify. Fatalities have increased five-fold since 1999 reaching a record high of 108,000 deaths in 2021. The epidemic has unfolded through distinct waves of different drug types, uniquely impacting various age, gender, race and ethnic groups in specific geographical areas. One major challenge in designing effective interventions is the forecasting of age-specific overdose patterns at the local level so that prevention and preparedness can be effectively delivered. We develop a forecasting method that assimilates observational data obtained from the CDC WONDER database with an age-structured model of addiction and overdose mortality. We apply our method nationwide and to three select areas: Los Angeles County, Cook County and the five boroughs of New York City, providing forecasts of drug-overdose mortality and estimates of relevant epidemiological quantities, such as mortality and age-specific addiction rates.SignificanceThe drug overdose epidemic in the United States continues to escalate, with fatalities increasing five-fold since 1999 and reaching a record high of 108,000 individuals in 2021. The crisis is characterized by distinct waves of drug types, disproportionately affecting various demographic groups in specific geographical regions. One major challenge in designing effective interventions is to forecast age-specific overdose patterns to facilitate targeted prevention and preparedness efforts. To this end, we propose a forecasting approach that integrates observational data with an age-structured model of addiction and overdose mortality. Applying this method nationwide and in areas that are highly impacted by the overdose crisis, we provide robust drug-overdose mortality forecasts offering vital insights for effective interventions.
The effects of positive personality on life insurance salespeople's customer orientation
Authors: Tsung You-Chien , Tseng Lu-Ming 
Published: September 2023

PurposeStudies have shown that customer orientation has a substantial impact on a business's success. This study examines the effects of positive personality on salespeople's proactive customer orientation (PCO) and responsive customer orientation (RCO) by incorporating the effects of job enthusiasm and transformational leadership.Design/methodology/approachA questionnaire survey is conducted. A total of 511 questionnaires are received from Taiwan's life insurance salespeople. Partial least squares (PLS) regression is used to test the hypotheses.FindingsThe results show that positive personality influences PCO and RCO both directly and indirectly through job enthusiasm. The effect of transformational leadership is also found to be significant. Financial service companies should be concerned about the important role of positive personality and transformational leadership in promoting job enthusiasm, PCO and RCO among salespeople.Originality/valuePrevious studies mostly focused on the direct relationship between customer orientation and organizational outcomes, neglecting the role of individual personality. This gap leaves us wondering how a positive personality influences a salesperson's proactive and responsive customer orientation. To the authors' knowledge, this is the first study to examine the mechanisms of a positive personality, job enthusiasm, and transformational leadership on salespeople's PCO and RCO.
Automation, artificial intelligence and future skills needs: an Irish perspective
Authors: Bukartaite Raimunda , Hooper Daire 
Published: September 2023

PurposeThis study explores insights from key stakeholders into the skills they believe will be necessary for the future of work as we become more reliant on artificial intelligence (AI) and technology. The study also seeks to understand what human resource policies and educational interventions are needed to support and take advantage of these changes.Design/methodology/approachThis is a qualitative study where a sample of highly experienced representatives from a range of small to large Irish organisations, both public and private, provide insights into this important topic.FindingsFindings indicate participants see a continued need for soft and hard skills as we evolve towards a more technologised workplace, with a need for employees to adopt a lifelong learning philosophy. As the knowledge economy in Ireland is well established, experts do not expect mass displacement to occur but differ with respect to the predicted rate of change. Novel HR interventions such as hiring for potential, pooling talent and establishing postgraduate supply contracts are seen as key. Current state interventions were mostly viewed positively but revamping of curricula is needed as well as stronger partnerships with tertiary institutions.Research limitations/implicationsThe interpretivist nature of the study limits the generalisability of the findings as they are based on a relatively small sample from one country. Also despite the significant expertise of the sample, it is not possible to predict whether their forecasts will manifest.Practical implicationsThis research highlights the need for Irish SMEs to embrace the impacts of automation and AI as many are seen to be slow in reacting to changes in technology. The study also reveals cutting edge talent management interventions for employers to adopt that will insulate them from the challenges technological change presents to recruitment and employee development.Originality/valueThe findings from this paper culminate in the development of a conceptual framework, which encapsulates the responsibilities of all parties so that future skills needs will be met. This highlights the interplay between employers, individuals/employees, the Irish Government and educational institutions, demonstrating how they are interdependent on one another as we move towards a more technologised future.
The impact of supervision on bank risk: empirical evidence from the Tunisian context
Authors: Belgacem Sana , Hadriche Manel , Belhaj Fethi 
Published: September 2023

PurposeThe purpose of this paper is to examine the impact of supervision on banking risk to determine whether prudential measures taken especially after financial crises are effective in limiting banking risks.Design/methodology/approachThe empirical study focused on 210 annual reports of almost all Tunisian banks during the 2010–2019 period. Banking supervision effectiveness is measured by enforcement outputs (i.e. on-site audits and sanctions). The generalized least squares method of multivariate analysis was used to analyze this study.FindingsThe results show that supervision set up and on-site audits reduce bank risk, while the relationship between sanctions and risk appears to be non-significant. The results still hold after robustness tests by changing the bank's risk-taking indicators.Practical implicationsThis study has important implications for managers and investors in the Tunisian context. In particular, the findings provide microevidence for the impact of supervision in Tunisian banks to reduce their risk-taking. The empirical results have important implications for the decision-making of bank managers and regulators in Tunisia as well as for relevant actors in similar emerging economies.Originality/valueThis study extends the previous literature on supervision by examining the relationship between supervision and banking risk in an emerging country, which has been little explored, Tunisia in particular. Furthermore, this study examines whether supervision reduces risk borne by Tunisian banks, and to the best of the researchers' knowledge, it is one of the pioneering studies of supervision in the Tunisian market. This latter market has different economic, political and social attributes compared to developed countries. So, this paper helps to clarify the impact of supervision enforcement and macroprudential policies. In addition, this paper strongly contributes to the various stakeholders “understanding of the importance and implication of supervision practices. However, since banks tend not to reduce their participation in risky activities to seek higher profits, supervisory policymakers and practitioners should also take a closer look at the composition of banks” investment portfolios to reduce moral hazard and regulatory arbitrage behavior. Empirically, the authors measure supervision by on-site audits and sanctions and examine how they affect bank risk level, which was never approached in Tunisia.
Digital wellbeing – a review of the JISC guidance from the UK and Vietnam
Authors: Foster Scott , Ly Thien Trang , Foster Anna Jayne , Ho Thi Hanh Tien , Knight Sarah 
Published: September 2023

PurposeThe aim of this paper is to contribute to the discussion of wellbeing within the university education system by outlining the key issues and benefits and recognising future research on digital well-being for students. The JISC Digital wellbeing paper highlights the many positive and negative impacts associated with digital wellbeing. This paper explores how some of these features have been considered within institutions within the UK and Vietnam and highlights the emerging research in one Vietnamese institution in relation to student wellbeing, where digital wellbeing was identified as a key concern.Design/methodology/approachThis is a technical review article which summarises key guidance for organisational digital wellbeing and then reflects on the application in the UK (a developed economy) and in Vietnam (one of the fastest growing economies). This is the first time a review has been conducted from the perspective of different countries. There are two aspects to digital wellbeing, individual and the social or organisational perspectives.FindingsThe JISC Digital wellbeing paper highlights the many positive and negative impacts associated with digital wellbeing. This paper explores how some of these features have been considered within institutions within the UK and Vietnam and highlights the emerging research in one Vietnamese institution in relation to student wellbeing, where digital wellbeing was identified as a key concern. The context of digital wellbeing within higher education is then discussed drawing similarities between the UK and Vietnamese student experiences whilst acknowledging the limitations of current research within the field.Originality/valueMany institutions have seen a rise in the number of wellbeing challenges, and there are few examples of specific initiatives aimed at addressing digital wellbeing challenges for their stakeholders. Existing research on students' wellbeing is predominately focused on undergraduate students and does not differentiate between undergraduate and postgraduate students, nor between masters, doctoral and professional level students and does not explore the impact of digital wellbeing discretely; this is an area which would benefit from future research.
Revolutionizing healthcare organizations with Operational Excellence and Healthcare 4.0: a systematic review of the state-of-the-art literature
Authors: Detwal Pankaj Kumar , Agrawal Rajat , Samadhiya Ashutosh , Kumar Anil , Garza-Reyes Jose Arturo 
Published: September 2023

Purpose
This study aims to examine current research on the relationship between Operational Excellence and Healthcare 4.0 (H4.0) for healthcare organizations.

Design/methodology/approach
The authors have performed a systematic literature review of 102 documents published between 2011 and 2022 from the Scopus database to identify the research trends on Operational Excellence and H4.0. Through a descriptive bibliometric analysis, this study has highlighted the year-wise trend in publication, top authors, prominent sources of publications, the country-wise spread of research activities and subject area analysis. Furthermore, through content analysis, this study has identified four clusters and proposed directions for future research of each identified cluster.

Findings
Results reflect overall growth in this area, with a few parts of the world being underrepresented in research related to Operational Excellence and H4.0. The content analysis focused on describing challenges pertaining to healthcare industries and the role of Operational Excellence tools and H4.0 technologies in dealing with various healthcare delivery aspects. The authors concluded their analysis by proposing a theoretical framework and providing theoretical and managerial implications of the study.

Originality/value
To the best of the authors’ knowledge, the paper is one of the first to analyze the existing literature on the healthcare sector at the interface of Operational Excellence and H4.0 technologies. The conceptual framework and cluster-wise future research prepositions are some of the unique offerings of the study.
Dividend policy and firm liquidity under the tax imputation system in Australia
Authors: Bai Min , Qin Yafeng , Bai Feng 
Published: September 2023

PurposeThe primary goal of this paper is to investigate the relationship between stock market liquidity and firm dividend policy within a market implementing the tax imputation system. The main aim is to understand how the tax imputation system influences the relationship between firm dividend policy and stock market liquidity within a cross-sectional framework.Design/methodology/approachThis paper investigates the relationship between stock market liquidity and the dividend payout policy under the full tax imputation system in the Australian market. This study uses the Generalized Least Squares regressions with firm- and year-fixed effects.FindingsIn contrast to the negative relationship between the liquidity of common shares and the firms' dividends documented in countries with the double tax system, the study reveals that in Australia, the dividend payout ratios are positively associated with liquidity after controlling for various explanatory variables with both the contemporaneous and lagged time periods. Such a finding is robust to the use of alternative liquidity proxies and to the sub-period tests and remains during the COVID-19 pandemic period.Research limitations/implicationsThe insights derived from this study have significant implications for various stakeholders within the economy. The findings provide regulators with valuable insights to conduct a more holistic assessment of how the tax system impacts the economy, especially concerning the dividend choices of firms. Within the context of a full tax imputation system, investors can make investment decisions without factoring in the taxation impact. Simultaneously, firms can be relieved of concerns about losing investors who prioritize liquidity, particularly when a high dividend payout might not align optimally with their financial strategy.Originality/valueThis study contributes to the literature by extending the literature on the tax clientele effects on dividend policy, providing evidence that the tax imputation system can moderate the impact of liquidity on dividend policy. This study examines the impact of the dividend tax imputation system on the substitution effect between dividends and liquidity.