bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of clay‐rich waste and industrial by‐products as effective inorganic soil amendments to enhance soil physical properties
Authors: Chalhoub Maha , Coussy Samuel , Simon Jeanne , Bataillard Philippe 
Published: January 2025

AbstractClay minerals play a crucial role in regulating the structure and functions of soils because of their chemical nature and their interactions with other soil constituents. In this context, a key objective of the research described in this article was to assess the extent to which the addition of various types of recycled clay‐rich materials to soils prone to crusting and erosion increase their clay content and improve their physical properties. Excavated soil (ExS), considered waste under European Union law, and quarry sludge (QS), an industrial by‐product of the washing process in mining operations, were used as soil amendments. ExS is dominated by swelling clay mineralogy such as interstratified illite‐smectite, whereas QS contains high level of non‐swelling clay minerals such as kaolinite and illite, and a low level of interstratified illite‐smectite. Lysimeters were filled with topsoil (0–30 cm) from an agricultural field. Treatments where the soil was amended with these materials were compared with a control without amendment. Lettuce was cultivated for three growing seasons. After 250‐days, the aggregate stability and water retention of the topsoil were measured. The equivalent pore‐size distribution (PSD), derived from the soil water retention curve, was analysed to predict soil water and aeration status. The application of QS to the topsoil enhanced soil structure without compromising lettuce productivity compared with the control and other treatments. However, amending topsoil with ExS decreased the stability because of the abundance of swelling clay minerals. Soil water retention at saturation increased from 27% in the control to 42% and 36% with ExS and QS amendments, respectively. At a pressure head >15,000 cm (residual pores <0.2 μm), water retention rose from 6% in the control to 19% with ExS and 14% with QS. The application of the clay‐rich material increased small pores compared with larger ones. This led to a minor increase in porosity responsible for water movement, aeration and root growth. This observation highlights the limitations of clay application benefits, which depend on the quantity and mineralogy of the clay and the presence of other binding agents. Further research is needed to investigate the combined effects of organic matter and clay‐rich materials on improving the soil structure and optimizing the pore size distribution for multiple functions.
Integrating Forestry and Local Administrative Data Using Semantic and GIS Technologies
Authors: Crespo‐Lera Natalia , Vega‐Gorgojo Guillermo , Giménez‐García José M. , Sarmiento Cristina Mayo , Bravo Felipe , Ruano Irene 
Published: January 2025

ABSTRACTLinking National Forest Inventory (NFI) data with local administrative units (LAUs) unlocks a wealth of benefits for forest management. It enhances precision in assessments, facilitates policy alignment, optimizes resource allocation, and enables effective monitoring and research at the local level. This study presents an automated process to convert official Spanish municipality geometries from the National Geographic Institute's geospatial database into Linked Open Data (LOD) format. This facilitates the assignment of Spanish NFI plots to their corresponding municipalities using GeoSPARQL and their publication in an open LOD repository. Additionally, we compared the results of this assignment with a GIS‐based solution. To demonstrate the potential of this spatial integration, we conducted analyses in two case studies. This work highlights the benefits of integrating forest information with other cross‐domain data using Semantic Web technologies, which can be further complemented by GIS software for spatial analysis.
Feasibility of home blood pressure screening in the paediatric outpatient clinic setting
Authors: Mackay Jessie R , Glenning Jonathan P , Grantham Brittany M , Clark Kylie , Mynard Jonathan P , Olweny Catherine N , Quinlan Catherine , Dabscheck Gabriel 
Published: January 2025

ObjectiveThe aim of this study was to evaluate the acceptability and feasibility of home-based blood pressure (BP) screening in a group of paediatric patients with known elevated risk of developing hypertension.DesignCross-sectional study.SettingSpecialist outpatient clinic and patient homes.Patients52 children and adolescents living with neurofibromatosis type 1.InterventionsClinic BP measured thrice manually and once via an automated device; home BP measured daily with the same device for 3 days.Main outcome measuresAcceptability and feasibility were assessed with a Children’s Anxiety Meter-State score, the comparability of home and clinic BPs, a parental survey, assessment of costs and the device return rate.ResultsHome systolic BP and diastolic BP were statistically similar to both clinic manual (95% CI −4.78 to 0.13; −4.80 to 0.93) and automatic BPs (95% CI −4.44 to 2.08; −0.54 to 5.52). Anxiety scores (95% CI −0.57 to 0.35) were also similar between settings. Participants and their families reported that home BP measurement was easy, took ~10 min and minimally interrupted family life. Families also largely preferred home BP screening (73% ‘yes’, 23% ‘not sure’, 3% ‘no’), and 90% returned their devices. Families reported substantial costs in attending clinic, which could be reduced with access to this home BP programme.ConclusionsHome BP screening was acceptable and feasible, with home BPs comparable to clinic measurements, no associated anxiety and preferred by families. Telehealth with home BP screening is a viable alternative to in-person appointments, which could reduce individual costs, and foster greater equity of care and access to health services.
Can large language models fully automate or partially assist paper selection in systematic reviews?
Authors: Chen Haichao , Jiang Zehua , Liu Xinyu , Xue Can Can , Yew Samantha Min Er , Sheng Bin , Zheng Ying-Feng , Wang Xiaofei , Wu You , Sivaprasad Sobha , Wong Tien Yin , Chaudhary Varun , Tham Yih Chung 
Published: January 2025

Background/aimsLarge language models (LLMs) have substantial potential to enhance the efficiency of academic research. The accuracy and performance of LLMs in a systematic review, a core part of evidence building, has yet to be studied in detail.MethodsWe introduced two LLM-based approaches of systematic review: an LLM-enabled fully automated approach (LLM-FA) utilising three different GPT-4 plugins (Consensus GPT, Scholar GPT and GPT web browsing modes) and an LLM-facilitated semi-automated approach (LLM-SA) using GPT4’s Application Programming Interface (API). We benchmarked these approaches using three published systematic reviews that reported the prevalence of diabetic retinopathy across different populations (general population, pregnant women and children).ResultsThe three published reviews consisted of 98 papers in total. Across these three reviews, in the LLM-FA approach, Consensus GPT correctly identified 32.7% (32 out of 98) of papers, while Scholar GPT and GPT4’s web browsing modes only identified 19.4% (19 out of 98) and 6.1% (6 out of 98), respectively. On the other hand, the LLM-SA approach not only successfully included 82.7% (81 out of 98) of these papers but also correctly excluded 92.2% of 4497 irrelevant papers.ConclusionsOur findings suggest LLMs are not yet capable of autonomously identifying and selecting relevant papers in systematic reviews. However, they hold promise as an assistive tool to improve the efficiency of the paper selection process in systematic reviews.
Short term complications of conisation and long term effects on fertility related outcomes in Denmark: register based nationwide cohort study
Authors: Aagaard Mathias , á Rogvi Jessica , Modin Frederikke , Nicolaisdóttir Dagny , Siersma Volkert , Brandt Brodersen John 
Published: January 2025

Abstract

Objective
To report on complications of conisation and its effects on fertility and stenosis.

Design
Register based nationwide cohort study on routinely collected data using several linked databases.

Setting
Primary and secondary care in Denmark, 2006-18.

Population
The conisation cohort comprised 48 048 conisations on women aged 23-65 who had undergone conisation within 120 days of a cervical biopsy. The biopsy cohort comprised 48 048 biopsies on women who had undergone a cervical biopsy but not conisation who were matched by age and time of procedure. Women were excluded from the conisation cohort before long term outcome analyses if they had undergone hysterectomy, resection of the uterus, or had cervical cancer or any long term outcomes within the 10 years before their conisation.

Main outcome measures
Bleeding, infection, and gynaecological operations within 30 days of conisation (stratified by age, year of conisation, and number of previous conisations) and long term risk of fertility treatment, fertility consultation, stenosis, cervical dilatation, infertility diagnoses, and death at any point after conisation. Long term outcomes were followed up until death, emigration, diagnosis of cervical cancer, hysterectomy or resection of uterus, or the end of 2018. Long term outcomes were analysed with incidence rate ratios from Cox regression models.

Results

Bleeding, infection, and gynaecological operations were registered for 2.81% (n=1351), 0.48% (n=231), and 3.95% (n=1897) of all conisations within 30 days of the procedure, respectively. Women in the conisation cohort had increased risk of stenosis (incidence rate ratio 14.81, 95% confidence interval 7.55 to 29.05, 0.41%
v
0.03% (n=176
v
12)) and cervical dilatation (2.68, 2.41 to 2.97, 4.01%
v
1.58% (n=1735
v
668)) compared with women in the biopsy cohort. No significant differences were observed for the other outcomes when adjusting for baseline covariates (such as age and region of residence). Cervical suturing after bleeding was associated with a substantial increase in the risk of stenosis and cervical dilatation.

Conclusion
This study found higher rates of complications within 30 days of conisation than previous studies with comparable outcome definitions, and a substantially increased risk of stenosis and cervical dilatation for women who had cervical suturing to treat bleeding after conisation. However, these results were based on few events in a small subgroup, and are therefore associated with major uncertainty. This study supports previous findings that conisation does not generally increase rates of infertility treatment or infertility diagnoses.
Effect of electronic cigarette atomising power and flavour on aerosol size-segregated metal concentration and inhalation risk
Authors: Lee Jinho , Afshar Masoud , Su Wei-Chung , Han Inkyu 
Published: January 2025

IntroductionAlthough numerous studies have estimated the inhalation dose of metals emitted from electronic cigarettes (e-cigs), the impact of factors including aerosol size and the atomising power of e-cig aerosols on estimating the inhalation dose of metals remains underexplored. A comprehensive understanding of these determinants is essential to assess the health risks associated with inhaling e-cig aerosols, which may contain potentially harmful metals.ObjectivesThe aim of this study is to elucidate the mass and inhalation doses of potentially harmful metals in e-cig aerosols by different particle size and their association with the various atomising powers of e-cig devices and flavours.MethodsSize-segregated e-cig aerosols were generated and collected in a exposure chamber, using an 11-stage cascade impactor for the analyses of aerosol mass and metals. The metal deposition dose in the human respiratory tract was calculated using a mathematical respiratory deposition estimation model and metal mass concentration by the size of aerosols.ResultsIn this study, the results showed that neither an increase in atomising power (from 5 to 20 W) nor e-cig flavours resulted in a significant increase in a metal deposition in the respiratory tracts. Although the factors did not significantly affect the calculated respiratory deposition of harmful metals under typical e-cig usage assumption, the estimated hazard index exceeded 1.0.ConclusionThe calculated health risks suggest substantial risks of inhalation of metal aerosols from e-cig use.
Preliminary results on the long-term operation of RPCs with eco-friendly gas mixtures under irradiation at the CERN Gamma Irradiation Facility
Authors:   The RPC ECOgas@GIF++ Collaboration:, Quaglia L. , Ramos D. , Abbrescia M. , Aielli G. , Aly R. , Arena M. C. , Barroso M. , Benussi L. , Bianco S. , Boscherini D. , Bordon F. , Bruni A. , Buontempo S. , Busato M. , Camarri P. , Cardarelli R. , Congedo L. , De Jesus Damiao D. , De Serio M. , Di Ciacco A. , Di Stante L. , Dupieux P. , Eysermans J. , Ferretti A. , Galati G. , Gagliardi M. , Garetti S. , Guida R. , Iaselli G. , Joly B. , Juks S. A. , Lee K. S. , Liberti B. , Ramirez D. Lucero , Mandelli B. , Manen S. P. , Massa L. , Pastore A. , Pastori E. , Piccolo D. , Pizzimento L. , Polini A. , Proto G. , Pugliese G. , Rigoletti G. , Rocchi A. , Romano M. , Samalan A. , Salvini P. , Santonico R. , Saviano G. , Sessa M. , Simone S. , Terlizzi L. , Tytgat M. , Vercellin E. , Verzeroli M. , Zaganidis N. 
Published: January 2025

Abstract
Since 2019, a collaboration between researchers from various institutes and experiments (i.e., ATLAS, CMS, ALICE, LHCb/SHiP and the CERN EP-DT group) has been operating several RPCs with diverse electronics, gas gap thicknesses and detector layouts at the CERN Gamma Irradiation Facility (GIF++). The studies aim at assessing the performance of RPCs when filled with new eco-friendly gas mixtures in avalanche mode and in view of evaluating possible aging effects after long high background irradiation periods, for example, high-luminosity LHC phase. This challenging research is also part of a task of the European AidaInnova project. A promising eco-friendly gas identified for RPC operation is the tetrafluoruropropene (C

$$_{3}$$

3

H

$$_{2}$$

2

F

$$_{4}$$

4

, commercially known as HFO-1234ze) that has been studied at the CERN GIF++ in combination with different percentages of CO

$$_2$$

2

. Between the end of 2021 and 2022, several beam tests have been carried out to establish the performance of RPCs operated with such mixtures before starting the irradiation campaign for the aging study. Results of these tests for different RPCs layouts and different gas mixtures, under increasing background rates are presented here, together with the preliminary outcome of the detector aging tests.
Interactions of Chronic Stress Exposure and Stress Appraisal on Vascular Endothelial Function Among Young Adults
Authors: Carlson Alyssa S. , Schwager Laura E. , Hart Thomas W. , Diesel Sara J. , Harris Jordan L. , Flores Mark , West Kylee , Thomas Emily B.K. , Jenkins Nathaniel D.M. 
Published: January 2025

Objective: We investigated the associations of ongoing, chronic stress exposure and stress appraisal on vascular endothelial function (VEF) in young adults. Methods: In 72 healthy young adults (74% female; age = 25±1 y), we assessed chronic stress exposure and appraisal with a measure that quantified chronic stress exposure and chronic stress appraisal related to 8 specific stressors over the last year. Participants completed the perceived stress scale (PSS) as a measure of global, proximal stress appraisal. VEF was assessed using the brachial artery flow mediated dilation technique. We examined relations among ongoing, chronic stress exposure and stress appraisal versus VEF adjusted for age and sex, and then assessed whether stress appraisal moderated the effect of chronic stress exposure on VEF. Results: Chronic stress exposure (β=−0.24, p=.045), but not chronic stress appraisal (β=0.07, p=.56) or perceived stress (β=−0.20, p=.11), was related to VEF. Perceived stress (p = .046), but not chronic stress appraisal ( p=.54), moderated the association between chronic stress exposure and VEF. The effect of chronic stress exposure on VEF ceased to be significant at a PSS score of ~22. Subsequent exploratory stratified analysis indicated that those with PSS ≥22 had increased exposure to adverse childhood experiences (+1.6±0.6, p=.01), greater depressive symptoms (+10.2±2.7, p<.001), and reduced psychological resilience (−7.6±3.5, p=.036). Conclusions: Chronic stress exposure significantly predicts impaired VEF among young adults. Further, this relation is influenced by proximal perceived stress, such that the association of chronic stress exposure on VEF may be obscured at high levels of proximal perceived stress.
Insurgências etnográficas
Authors: Lopes Pedro , Varjão João Victtor Gomes , Fiori Ana Letícia de 
Published: January 2025

Em nosso número 32.2, a Ponto Urbe apresenta ao público leitor um instigante conjunto de textos, entre as seções de Artigos, Etnográfica, Ensaio Fotográfico, Entrevista, Tradução e Dossiês. Pelas diferentes trilhas de cada contribuição, seguimos com a confiança da etnografia como perspectiva potente para a análise do social, bem como ferramenta para insurgências. Nesta edição, reunimos trabalhos sobre ciências, artes e políticas, sobre saberes tradicionais, afetos e moralidades. Contamos com relatos etnográficos do Setembro Surdo em Juiz de Fora, em ensaio fotográfico de feitio autobiográfico que transborda também para nossa capa, uma entrevista com a pesquisadora Claudia Alexandre, a tradução de um texto clássico de Lewis Morgan e um dossiê sobre "Antropologia da Música" e um que aborda "Novos horizontes do desejo". Boa leitura a todes.
Abstract 091: Efficacy and Safety of Andexanet Alpha Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta‐Analysis
Authors: Sarhan K. , Mohamed R. G. , Elmahdi R. , Mohsen Y. , Elsayed A. , Zayed D. , Elkholi M. A. , Gabr N. , El-Bialy E. M. , Serag I. 
Published: January 2025

Introduction
Factor Xa inhibitors (FXaI) are increasingly used for anticoagulation therapy, yet their association with intracranial hemorrhage poses a significant challenge. While Andexanet alpha (AA) and four factor prothrombin complex concentrate (4F‐PCC) have shown promise in reversing FXaI effects their comparative efficacy and safety remain uncertain.

Methods

Following the PRISMA guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until 16
th
of May 2024. Our primary outcomes were successful anticoagulation reversal, overall mortality including 30‐day and in hospital mortality, and thromboembolic events. Secondary outcomes were length of hospital and ICU stay and hematoma volume expansion. Data was pooled using random effects model.

Results
We included 16 eligible studies including the ANNEXA‐1 trial with a total of 2977 patients. A statistically significant improvement in hemostatic efficacy rates were in favor of the AA group (RR 1.10, 95% CI [1.01, 1.20], P = 0.02). Lower overall mortality rates were found in the AA group (RR 0.67, 95% CI [0.51, 0.88], P = 0.004). However, no difference was found in 30‐day mortality rates (RR 0.82, 95% CI [0.58, 1.16], P = 0.26). In terms of thromboembolic events, more events were found in the AA group (RR 1.47, 95% CI [1.01, 2.15], P = 0.046). AA was associated with a longer duration of hospital stay compared to 4F‐PCC (MD 0.64, 95% CI [0.07, 1.22], P = 0.03). Neither a significant difference in length of ICU stays (MD 0.25, 95% CI [‐0.36, 0.86], P = 0.41) nor in hematoma volume expansion was reported (MD ‐0.89, 95% CI [‐3.11, 1.34], P = 0.435).

Conclusion
Our results suggest that AA is superior to 4F‐PCC in enhancing the hemostatic efficacy and reducing the overall and in‐hospital mortality rates. More thromboembolic events are thought to be associated with the use of AA. However, more studies are required to validate whether the better results of AA in improving hemostatic efficacy are enough to make up for their higher cost and their possible risk of thromboembolic events.
On the intriguing Q phyllosoma larva (Decapoda, Scyllaridae): A visitor from the deep sea?
Authors: Canto-García Ashanti A. 
Published: January 2025

Abstract
A peculiar phyllosoma larva at an intermediate stage was collected in 2006 during a plankton survey in the Mexican Caribbean. Its body length was 7.3 mm. This phyllosoma resembles those of species of Scyllaridae Latreille, 1825 with characters including a pear-shaped cephalic shield, the presence of pereiopod 5 with setae, and traits typical of Scyllarus Fabricius, 1775 at early stages viz., uniramous antenna, circular thorax, and a shallow abdomen. Previously, this phyllosoma had only been reported from Florida, but at a more advanced stage of development. Based on morphological comparison with records of Atlantic phyllosoma larvae, it is considered unlikely that this individual belongs to any of the species previously reported from the Caribbean subregion. Instead, it is proposed that this peculiar larva belongs to the deep-living scyllarid genus Bathyarctus Holthuis, 2002, as it seems more likely that this deep-living larva was vertically transported to the epipelagic layers of the Caribbean.
Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD
Authors: Majumder Pritha , Chatterjee Biswanath , Akter Khadiza , Ahsan Asmar , Tan Su Jie , Huang Chi-Chen , Chu Jen-Fei , Shen Che-Kun James 
Published: January 2025

Abstract

Background
Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning/memory development. The trafficking of mRNAs along the hippocampal neuron dendrites remains translationally silent until they are selectively transported into the spines upon glutamate-induced receptor activation. However, the molecular mechanism(s) behind the spine entry of dendritic mRNAs under metabotropic glutamate receptor (mGluR)-mediated neuroactivation and long-term depression (LTD) as well as the fate of these mRNAs inside the spines are still elusive.

Method
Different molecular and imaging techniques, e.g., immunoprecipitation (IP), RNA-IP, Immunofluorescence (IF)/fluorescence in situ hybridization (FISH), live cell imaging, live cell tracking of RNA using beacon, and mouse model study are used to elucidate a novel mechanism regulating dendritic spine transport of mRNAs in mammalian neurons.

Results
We demonstrate here that brief mGluR1 activation-mediated dephosphorylation of pFMRP (S499) results in the dissociation of FMRP from TDP-43 and handover of TDP-43/Rac1 mRNA complex from the dendritic transport track on microtubules to myosin V track on the spine actin filaments. Rac1 mRNA thus enters the spines for translational reactivation and increases the mature spine density. In contrast, during mGluR1-mediated neuronal LTD, FMRP (S499) remains phosphorylated and the TDP-43/Rac1 mRNA complex, being associated with kinesin 1-FMRP/cortactin/drebrin, enters the spines owing to Ca2+-dependent microtubule invasion into spines, but without translational reactivation. In a VPA-ASD mouse model, this regulation become anomalous.

Conclusions
This study, for the first time, highlights the importance of posttranslational modification of RBPs, such as the neurodevelopmental disease-related protein FMRP, as the molecular switch regulating the dendrite-to-spine transport of specific mRNAs under mGluR1-mediated neurotransmissions. The misregulation of this switch could contribute to the pathogenesis of FMRP-related neurodisorders including the autism spectrum disorder (ASD). It also could indicate a molecular connection between ASD and neurodegenerative disease-related protein TDP-43 and opens up a new perspective of research to elucidate TDP-43 proteinopathy among patients with ASD.