bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of patients with germline predisposition to haematological malignancies considered for allogeneic blood and marrow transplantation: Best practice consensus guidelines from the UK Cancer Genetics Group (UKCGG), CanGene‐CanVar, NHS England Genomic Laboratory Hub (GLH) Haematological Malignancies Working Group and the British Society of Blood and Marrow Transplantation and cellular therapy (BSBMTCT)
Authors: Clark Andrew , Thomas Sally , Hamblin Angela , Talley Polly , Kulasekararaj Austin , Grinfeld Jacob , Speight Beverley , Snape Katie , McVeigh Terri P. , Snowden John A. 
Published: February 2023

SummaryGermline predisposition to haematological cancers is increasingly being recognised. Widespread adoption of high‐throughput and whole genome sequencing is identifying large numbers of causative germline mutations. Constitutional pathogenic variants in six genes (DEAD‐box helicase 41 [DDX41], ETS variant transcription factor 6 [ETV6], CCAAT enhancer binding protein alpha [CEBPA], RUNX family transcription factor 1 [RUNX1], ankyrin repeat domain containing 26 [ANKRD26] and GATA binding protein 2 [GATA2]) are particularly significant in increasing the risk of haematological cancers, with variants in some of these genes also associated with non‐malignant syndromic features. Allogeneic blood and marrow transplantation (BMT) is central to management in many haematological cancers. Identification of germline variants may have implications for the patient and potential family donors. Beyond selection of an appropriate haematopoietic stem cell donor there may be sensitive issues surrounding identification and counselling of hitherto asymptomatic relatives. If BMT is needed, there is frequently a clinical urgency that demands a rapid integrated multidisciplinary approach to testing and decision making involving haematologists in collaboration with Clinical and Laboratory Geneticists. Here, we present best practice consensus guidelines arrived at following a meeting convened by the UK Cancer Genetics Group (UKCGG), the Cancer Research UK (CRUK) funded CanGene‐CanVar research programme (CGCV), NHS England Genomic Laboratory Hub (GLH) Haematological Oncology Malignancies Working Group and the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT).
α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss
Authors: Guo Qingyun , Kawahata Ichiro , Jia Wenbin , Wang Haoyang , Cheng An , Yabuki Yasushi , Shioda Norifumi , Fukunaga Kohji 
Published: February 2023

AbstractAimsWe previously found that a decoy peptide derived from the C‐terminal sequence of α‐Synuclein (αSyn) prevents cytotoxic αSyn aggregation caused by fatty acid‐binding protein 3 (FABP3) in vitro. In this study, we continued to utilize αSyn‐derived peptides to further validate their effects on αSyn neurotoxicity and behavioral impairments in αSyn preformed fibrils (PFFs)‐injected mouse model of Parkinson's disease (PD).MethodsMice were injected with αSyn PFFs in the bilateral olfactory bulb (OB) and then were subjected to behavioral analysis at 2‐week intervals post‐injection. Peptides nasal administration was initiated one week after injection. Changes in phosphorylation of αSyn and neuronal damage in the OB were measured using immunostaining at week 4. The effect of peptides on the interaction between αSyn and FABP3 was examined using co‐immunoprecipitation.ResultsαSyn PFF‐injected mice showed significant memory loss but no motor function impairment. Long‐term nasal treatment with peptides effectively prevented memory impairment. In peptide‐treated αSyn PFF‐injected mice, the peptides entered the OB smoothly through the nasal cavity and were mainly concentrated in neurons in the mitral cell layer, significantly suppressing the excessive phosphorylation of αSyn and reducing the formation of αSyn‐FABP3 oligomers, thereby preventing neuronal death. The addition of peptides also blocked the interaction of αSyn and FABP3 at the recombinant protein level, and its effect was strongest at molar concentrations comparable to those of αSyn and FABP3.ConclusionsOur findings suggest that the αSyn decoy peptide represents a novel therapeutic approach for reducing the accumulation of toxic αSyn‐FABP3 oligomers in the brain, thereby preventing the progression of synucleinopathies.
A novel biologically hierarchical hydrogel with osteoblast precursor‐targeting extracellular vesicles ameliorates bone loss in vivo via the sequential action of antagomiR‐200b‐3p and antagomiR‐130b‐3p
Authors: Dai Hanhao , Yu Yunlong , Han Junyong , Luo Jun , Song Chao , Deng Zhibo , Wu Yijing , Ke Dianshan , Xu Jie 
Published: February 2023

AbstractOsteoporotic fracture is a major health problem plaguing the ageing society, and improving its treatment is an urgent challenge. How to ameliorate bone loss determines the recovery of such fractures. Extracellular vesicle (EV)‐loaded hydrogel has the capacity to treat osteoporotic fractures due to its pro‐osteogenic property. And balancing proliferation and maturation of osteoblast precursors (OBPs) is of great significance to avoid OBP depletion, which is lacking in current treatment. Based on osteoblastogenic miRNAs, this study aimed to explore the efficacies of the combination of hierarchical hydrogel and EVs altering functional miRNAs level in bone loss. Through bioinformatics analyses, we screened out proliferative gene‐targeting miR‐200b‐3p and osteogenic gene‐targeting miR‐130b‐3p. And antagomiR‐200b‐3p (ant‐200b) enhanced OBP proliferation, and antagomiR‐130b‐3p (ant‐130b) promoted OBP differentiation. After confirming the directional effect of Fibronectin (Fn1) on OBPs, we prepared OBP‐targeting EVs. Furthermore, encapsulation of two antagomiRNAs in EVs enhanced the respective effect of ant‐200b and ant‐130b. Notably, hierarchically injectable hydrogel exerted an effective function in promoting the sequential delivery of EVs‐200b and EVs‐130b. Importantly, hierarchical hydrogel containing dual EVs effectively ameliorated bone loss. Overall, hierarchical hydrogel based on two antagomiRNAs effectively improves bone loss in vivo due to its role in promoting OBP proliferation and maturation sequentially.
Person‐first language in diabetes and obesity scientific publications
Authors: Dickinson Jane K. , Bialonczyk Damian , Reece Jessica , Kyle Theodore K. , Close Kelly L. , Nadglowski Joseph , Johnson Katie , Garza Matthew , Pash Elizabeth , Chiquette Elaine 
Published: February 2023

AbstractAimsWe aimed to quantify the use of person‐first language (PFL) among scholarly articles focusing on diabetes or obesity.MethodsPFL and condition‐first language (CFL) terms for diabetes and obesity (e.g. diabetic, obese) were identified from existing guidelines and a review of the literature. Exact phrase literature searches were conducted between 2011 and 2020 and results were categorised as PFL, CFL or both.ResultsAmong diabetes articles, 43% used PFL, 40% used CFL and 17% contained both. Among obesity articles, 0.5% used PFL, 99% used CFL and 0.2% used both. The use of PFL increased by 3% per year for diabetes articles, compared to 117% for obesity articles. The rate of adoption of PFL in diabetes articles was unchanged in 2018–2020 compared to the 3 years prior.ConclusionsWhile the use of person‐first language in diabetes articles had increased over the review period, its rate of adoption has started to slow. Conversely, the use of PFL in obesity articles is nascent and increasing.
Burden of liver complications related to non‐alcoholic fatty liver disease in China from 2005 to 2019: Observations from the Global Burden of Disease Study, 2019
Authors: Liu Huixin , Qi Jinlei , Yang Jia , Liu Feng , Li Xiaohe , Yin Peng , Wang Lijun , Liang Zhisheng , Wei Lai , Rao Huiying , Zhou Maigeng 
Published: February 2023

AbstractAimTo assess the burden of liver complications related to non‐alcoholic fatty liver disease (LC‐NAFLD) from 2005 to 2019 in China.Materials and MethodsWe used data from the Global Burden of Disease, Injuries, and Risk Factors Study, 2019, to present contemporary and varying profiles of China's LC‐NAFLD burden. The Joinpoint Regression model and Gaussian process regression were, respectively, used to estimate the annual percentage change in prevalence rates and disability‐adjusted life‐year (DALY) rates, and the relationship between the sociodemographic index (SDI) and age‐standardized rates of LC‐NAFLD.ResultsIn 2019, China had 293.42 million (95% uncertainty interval [UI]: 263.69‐328.44) LC‐NAFLD cases with a prevalence rate and DALYs of 20.63 (95% UI: 23.09‐18.54) per 1000 people and 591.03 thousand (95% UI: 451.25‐737.33), respectively. North China had the highest prevalence but the lowest DALYs of LC‐NAFLD, whereas Southwest China had the lowest prevalence but the highest DALYs. LC‐NAFLD were more common in men than in women (male: female ratio, 1.27) in 2019. From 2005 to 2019, the prevalence of NAFLD cases increased by 68.32% (from 174.32 million in 2005 to 293.42 million in 2019), mainly because of an age‐specific prevalence rate increase.ConclusionThe LC‐NAFLD burden in China is substantial and has increased markedly over the past 15 years. Effective measures for low SDI regions and men are needed to address the rapidly increasing NAFLD burden.
Immunization status in patients with multiple sclerosis: A cross‐sectional, monocenter study in Austria
Authors: Berek Klaus , Deisl Philipp , Bichler Maximilian , Auer Michael , Barket Robert , Bauer Angelika , Zinganell Anne , Di Pauli Franziska , Deisenhammer Florian , Hegen Harald 
Published: February 2023

AbstractBackground and purposePatients with multiple sclerosis (MS) under certain disease‐modifying therapies (DMT) show a higher risk of infection and a lower immune response to vaccination. Hence, assessing immunization status prior to DMT start and, where necessary, performing vaccinations is recommended. We aimed to determine the immunization status in MS patients and to identify factors associated with low vaccination rates.MethodsPatients with MS who were seen at the MS clinic of the Medical University of Innsbruck throughout a period of 14 months in 2020 and 2021 were eligible for inclusion into this prospective, single‐center study. Immunization status against 17 different pathogens was obtained from vaccination certificate and by patient questionnaire. Antibody detection against seven antigens was performed in peripheral blood.ResultsOf 424 patients with MS at a mean age of 43 ± 12 years, the vast majority had vaccinations against tetanus (94%), diphtheria (92%), and poliomyelitis (90%), whereas a lower proportion had vaccinations against tick‐borne encephalitis (70%), pertussis (69%), hepatitis B (65%), rubella (55%), hepatitis A (50%), measles (49%), mumps (47%), and only a minority against influenza (10%), pneumococcal (6%) and meningococcal disease (4%), human papillomavirus (4%), yellow fever (2%), and varicella zoster virus (1%). A total of 87% received vaccination against SARS‐CoV‐2. Overall, higher vaccination rates were associated with younger age, relapsing disease course, and education level. Misinformation on infectious diseases and vaccines was associated with lower vaccination rates.ConclusionsThe majority of MS patients did not fulfil vaccination recommendations. Efforts to increase vaccination rates, preferentially before DMT start, should be promoted.
Stress recognition with multi‐modal sensing using bootstrapped ensemble deep learning model
Authors: Singh Ghanapriya , Phukan Orchid Chetia , Kumar Ravinder 
Published: February 2023

AbstractThe factors that influence a person's mental health are numerous, interconnected, and multi‐dimensional. Recognition of stress is one of the facets in developing the Mental Healthcare (MHC) system framework. With the advent of technology, smart wearable devices have paved a way to collect data in real‐time to provide the cutting‐edge reports about the individual. Due to the physiological sensors present in the smart wearable devices, it is now possible to have a robust system to recognize the stress of the smart wearable devices user thus consecutively leading to recognition of factors in leading to stress. However, the current MHC system for recognition and identification of stress have several drawbacks. First, stress recognition is mostly designed for a particular group of individuals like occupational stress, perinatal maternal stress, or health worker stress and fails to propose a framework that would not be targeted for a particular group of individual. Second, most of the previous work done on stress recognition focuses on the extraction of handcrafted features thus requiring human intervention and expertise. To address these issues, this study proposes, a hybrid deep learning based ensemble approach for automated extraction of features and classification into various state of stress for MHC system. The proposed framework takes input from wearable physiological sensors and is provided to deep learning classifier of convolutional neural network (CNN) and CNN‐long short term memory based ensemble model. The proposed framework has been experimented on the wearable stress and affect detection dataset and reports an accuracy of 91.52% that is 7.20% higher than earlier reported accuracies from other machine learning and deep learning models.
Early exposure to adverse childhood experiences and delinquent peer association among youth
Authors: Jones Melissa S. , Pierce Hayley , Shoaf Hannah 
Published: February 2023

AbstractObjectiveThis study examines the relationships between cumulative, timing of, and duration of early adverse childhood experiences (ACEs) and delinquent peer association among youth.BackgroundNegative life outcomes associated with delinquent peer affiliation among youth are well established; however, less research has considered how or whether ACEs influence these processes.MethodsData were from the longitudinal Fragile Families and Child Wellbeing Study (n = 3,060). Negative binomial regression models were to assess the relationship between early ACEs (i.e., accumulation, timing/duration) and delinquent peer association.ResultsOur results indicate that as the number of ACEs (by age 5) incrementally increase, the likelihood of reported involvement with delinquent peers increases. Moreover, when it comes to timing and duration of ACE exposure, ACEs that are high but late, intermittent, or chronically high significantly increase the risk of delinquent peer association.Conclusion and implicationsOverall, early ACEs play an important role in delinquent peer association during adolescence. Interventions and preventions strategies, such as psychological first aid and trauma‐informed health care, can help reduce the negative consequences of early ACE exposure, including the risk of associating with delinquent peers.
Length–length relationships for the main shark species caught in the commercial shark fisheries of Western Australia
Authors: Bartes Saia Nahir , Braccini Matías 
Published: February 2023

AbstractLength–length relationships are presented for 19 shark species caught in the commercial shark fisheries of Western Australia. A robust linear regression model was used to estimate the relationship between interdorsal, total and fork lengths. Sharks are typically landed as trunks, so information generated in our study is essential for converting partial lengths to total lengths for reconstructing catch composition, an essential step for assessing the status of shark populations.
Species sensitivity and functional uniqueness determine the response of macroinvertebrate functional diversity to species loss in urban streams
Authors: Gao Jin , Peng Zhiqi , Zang Haoming , Wang Yinchang , Ding Ning , He Siwen , Datry Thibault , Wang Beixin 
Published: February 2023

Abstract

Land‐use change, particularly urbanisation, has led to an unprecedented decline in species and functional diversity worldwide. However, the mechanism through which such species loss affects functional diversity remains unclear. Here, we aimed to elucidate this mechanism from the perspectives of the association between species sensitivity and functional uniqueness (i.e., their relative contribution to functional diversity) and their related functional traits.

We collected stream macroinvertebrates and measured environmental and land‐use variables from 152 sites in the highly urbanised Qiantang River Basin in the Zhejiang Province of eastern China. Firstly, we evaluated the sensitivity to urbanisation and functional uniqueness of each macroinvertebrate taxon to identify their association patterns. Secondly, we examined the decline in functional diversity in response to taxon loss by comparing simulated ordered and random taxon loss scenarios. Finally, we identified sensitivity‐related traits (SRT) and functional uniqueness‐related traits (URT) using the Mann–Whitney U‐test to elucidate their role in shaping functional response patterns to taxon loss.

Urbanisation showed a remarkable effect on the taxonomic and functional diversity of macroinvertebrates. Functional diversity declined nonlinearly with taxon loss, with the threshold response shifting to a rapid decline after 29.7%–60.0% taxa were lost. The sensitivities of ephemeropteran, plecopteran and trichopteran taxa (EPT) were negatively associated with their functional uniqueness, although this association was not detected when considering all macroinvertebrates. We identified 11 SRT and nine URT, but only one URT overlapped SRT.

The association between species sensitivity and its functional uniqueness shapes functional decline patterns in response to taxon loss. Overlap patterns of SRT and URT offer novel insights into mechanisms underlying stress‐induced decline in functional diversity.

The process of functional diversity decline in response to species loss caused by urbanisation also may be affected by species turnover or even compensated for by non‐native species in real world ecosystems. How functional diversity responds to species loss remains an open topic that needs to be cautiously addressed.
Resetting urban human‐microbial relations in pandemic times
Authors: Maller Cecily Jane 
Published: February 2023

AbstractMicrobes, particularly of the viral kind, are currently preoccupying human activity and concerns due to the COVID‐19 pandemic. Although for a long time there has been fear associated with ‘germs’, notably viruses and bacteria and the diseases they cause, the pandemic has set these fears into overdrive. As serious as this ongoing event is, there are broader interests and important alternative narratives about the microbial world permeating current thinking, based on research that intersects with and includes biopolitical and relational research in geography. In an attempt at balancing the prevailingly negative discourses about microbes and the potential harms they can cause, and to encourage more geographers to contribute to understanding human‐microbial relations, this paper draws together recent research across disciplines to discuss the prevalence and role of microbes in environments and in and on human bodies. Drawing on ideas of more‐than‐human care, the paper shows how geographers and other social scientists can and are already helping reset human‐microbial relations, and where further work can productively be done.
“In this together”? Gender inequality associated with home‐working couples during the first COVID lockdown
Authors: Nagy Beáta , Geambașu Réka , Gergely Orsolya , Somogyi Nikolett 
Published: February 2023

AbstractThe first lockdown, conferred upon us by the COVID‐19 outbreak in March 2020, created a unique, 3‐month‐long, laboratory‐like situation that made gender relations and women's work especially relevant for social research. Full‐time employed parents who switched to working from home were in a unique position to renegotiate the division of housework, childcare, or the management of school‐related tasks. This paper explores what happened to the gendered division of unpaid work and what factors explain the (failed) renegotiation between full‐time working parents. To explore this issue, we interviewed 52 Hungarian‐speaking mothers in two countries, Hungary and Romania, who were living in heterosexual dual‐earner families with children under the age of 14, and who were working full‐time. Results show that, despite the unusual situation, the usual pattern of the division of unpaid work was sustained by most parents. Even though they were unhappy and sometimes overwhelmed with their workload, most mothers did not mind the division of care duties. Research findings deliver evidence that mothers' lack of willingness and ability to renegotiate the division of unpaid labor in the household was determined both from “inside” and “outside” households. The gendered nature of care work and intensive parenting and mothers' position in the labor market, including the flexibility of their employment, are two sets of mutually interwoven factors that contributed to women's lack of willingness to challenge the unequal division of reproductive work.
“I only wanted one thing and that was to be who I am now”: Being a trans young adult and (re)negotiating vocational identity
Authors: Corlett Sara , Stutterheim Sarah E. , Whiley Lilith A. 
Published: February 2023

AbstractDeveloping vocational identity as a young adult is a complex feat and may be even more so for transgender people, who have to navigate their professional selves in a largely cisgender and heteronormative world that minoritizes them. This qualitative study explores how transgender youths develop a vocational identity. Through 10 in‐depth interviews in the Netherlands and Belgium, we found that participants had to negotiate favoring education (at the expense of gender transition) or sensemaking their gender identity (at the expense of schooling), while seeking to avoid discrimination. In addition, we observed that transitioning was also an enabling process, facilitating the development of trans young adults' vocational identity. We also found that trans young adults see the (un)attainability of career paths related to anticipated stigmatization and other expectations related to their trans identities. In particular, they mentioned occupations where hegemonic masculinity and gender binarism are praised, while those involving interaction with children and teenagers are not attainable. Organizations celebrating their trans identity and career paths in which the living conditions of other minoritized people are improved were perceived as attainable and desirable. The insights presented here show that even in countries that are considered “progressive” in terms of LGBTQ+ rights, the vocational identity of trans youth is nevertheless influenced by (and at times constrained by) their gender identity. The need for career counselors, educational institutions, and organizations to work on facilitating the future career development of trans individuals and their access to inclusive spaces is discussed.