bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Digitally assisted nonlinearity suppression architecture using over‐the‐air beam cancelation
Authors: Mu Qin , Li Nanxi , Chen Cong , Wei Xiaozheng , Wen Rong , Wu Muqing , Li Xiang , Liu Ying 
Published: April 2023

AbstractUsing a large number of power amplifiers brings serious nonlinear distortion to 5G communication systems, which becomes a challenging problem for conventional digital predistortion (DPD) to linearize signals. To address this challenge, we propose a digitally assisted nonlinearity suppression architecture for applications in multiple antenna arrays. In this architecture, we use an auxiliary array to generate a nonlinear cancelation signal to cancel with the main beam at the receiving end. We explore a two‐step method to model the nonlinear signal and combine neural network to complete the modeling. In addition, we introduce a novel method for estimating and tracking the channel to update the model coefficients. To verify the proposed methods, we design a scene and compare the performance of our architecture with that of conventional DPD. Our experiments demonstrate that our proposed methods can significantly enhance the adjacent channel power leakage ratio performance by 12 dB while also optimizing in‐band distortion. Moreover, our architecture outperforms conventional DPD approaches even with enhanced distortion.
Cognitive dysfunction and increased phosphorylated tau are associated with reduced O‐GlcNAc signaling in an aging mouse model of metabolic syndrome
Authors: Gupta Shreya , Jinka Sanjay K. A. , Khanal Saugat , Bhavnani Neha , Almashhori Fayez , Lallo Jason , Mathias Amy , Al‐Rhayyel Yasmine , Herman Danielle , Holden John G. , Fleming Sheila M. , Raman Priya 
Published: April 2023

AbstractMetabolic syndrome (MetS), characterized by hyperglycemia, obesity, and hyperlipidemia, can increase the risk of developing late‐onset dementia. Recent studies in patients and mouse models suggest a putative link between hyperphosphorylated tau, a component of Alzheimer's disease‐related dementia (ADRD) pathology, and cerebral glucose hypometabolism. Impaired glucose metabolism reduces glucose flux through the hexosamine metabolic pathway triggering attenuated O‐linked N‐acetylglucosamine (O‐GlcNAc) protein modification. The goal of the current study was to investigate the link between cognitive function, tau pathology, and O‐GlcNAc signaling in an aging mouse model of MetS, agouti KKAy+/−. Male and female C57BL/6, non‐agouti KKAy−/−, and agouti KKAy+/− mice were aged 12–18 months on standard chow diet. Body weight, blood glucose, total cholesterol, and triglyceride were measured to confirm the MetS phenotype. Cognition, sensorimotor function, and emotional reactivity were assessed for each genotype followed by plasma and brain tissue collection for biochemical and molecular analyses. Body weight, blood glucose, total cholesterol, and triglyceride levels were significantly elevated in agouti KKAy+/− mice versus C57BL/6 controls and non‐agouti KKAy−/−. Behaviorally, agouti KKAy+/− revealed impairments in sensorimotor and cognitive function versus age‐matched C57BL/6 and non‐agouti KKAy−/− mice. Immunoblotting demonstrated increased phosphorylated tau accompanied with reduced O‐GlcNAc protein expression in hippocampal‐associated dorsal midbrain of female agouti KKAy+/− versus C57BL/6 control mice. Together, these data demonstrate that impaired cognitive function and AD‐related pathology are associated with reduced O‐GlcNAc signaling in aging MetS KKAy+/− mice. Overall, our study suggests that interaction of tau pathology with O‐GlcNAc signaling may contribute to MetS‐induced cognitive dysfunction in aging.
Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue
Authors: Bragato Cinzia , Pistocchi Anna , Bellipanni Gianfranco , Confalonieri Stefano , Balciuniene Jorune , Monastra Federica Maria , Carra Silvia , Vitale Giovanni , Mantecca Paride , Cotelli Franco , Gaudenzi Germano 
Published: April 2023

AbstractClassical dynamins (DNMs) are GTPase proteins engaged in endocytosis, a fundamental process for cargo internalization from the plasma membrane. In mammals, three DNM genes are present with different expression patterns. DNM1 is expressed at high levels in neurons, where it takes place in the recycling of synaptic vesicles; DNM2 is ubiquitously expressed, while DNM3 is found in the brain and in the testis. Due to the conservation of genes in comparison to mammals, we took advantage of a zebrafish model for functional characterization of dnm1a, ortholog of mammalian DNM1. Our data strongly demonstrated that dnm1a has a nervous tissue‐specific expression pattern and plays a role in the formation of both axon and synapse. This is the first in vivo study that collects evidence about the effects of dnm1a loss of function in zebrafish, thus providing a new excellent model to be used in different scientific fields.
Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses
Authors: Rosario Ryan , Arruda Ellen M. , Grant John A. , Coleman Rhima M. 
Published: April 2023

AbstractOsteochondral allograft implantation is a form of cartilage transplant in which a cylindrical graft of cartilage and subchondral bone from a donor is implanted into a patient's prepared articular defect site. No standard exists for matching the cartilage thickness of the donor and recipient. The goal of this study was to use finite element (FE) analysis to identify the effect of cartilage thickness mismatches between donor and recipient cartilage on cartilage stresses in patellar transplants. Two types of FE models were used: patient‐specific 3D models and simplified 2D models. 3D models highlighted which geometric features produced high‐stress regions in the patellar cartilage and provided ranges for the parameter sweeps that were conducted with 2D models. 2D models revealed that larger thickness mismatches, thicker recipient cartilage, and a donor‐to‐recipient cartilage thickness ratio (DRCR) < 1 led to higher stresses at the interface between the donor and recipient cartilage. A surface angle between the donor‐recipient cartilage interface and cartilage surface normal near the graft boundary increased stresses when DRCR > 1, with the largest increase observed for an angle of 15°. A surface angle decreased stresses when DRCR < 1. Clinical Significance: This study highlights a potential mechanism to explain the high rates of failure of patellar OCAs. Additionally, the relationship between geometric features and stresses explored in this study led to a hypothetical scoring system that indicates which transplanted patellar grafts may have a higher risk of failure.
Sensory characterization of the perceived quality of East African highland cooking bananas (matooke)
Authors: Khakasa Elizabeth , Muyanja Charles , Mugabi Robert , Bugaud Christophe , Forestier‐Chiron Nelly , Uwimana Brigitte , Arinaitwe Ivan Kabiita , Nowakunda Kephas 
Published: April 2023

AbstractBACKGROUNDIt has recently become increasingly evident that banana projects in Uganda need to consider consumer preferences as part of the breeding process to increase the acceptability of new cultivars. A trained panel used quantitative descriptive analysis (QDA) as a tool to assess the sensory characteristics of 32 cooking bananas (matooke). The aim was to investigate which sensory characteristics best describe matooke.RESULTSFourteen descriptors were generated. The preferred attributes of matooke were high‐intensity yellow color, homogeneous distribution of yellow color, good matooke aroma, highly moldable by touch, moist and smooth in the mouth. Analysis of variance revealed significant differences in the yellowness, homogeneity of color, firmness, moistness, smoothness, matooke aroma, hardness, and moldability across the genotypes (P < 0.05). Principal component analysis (PCA) showed strong positive correlations between yellowness and homogeneity of the color (R = 0.92). Smoothness in the mouth and moldability by touch were strongly and positively correlated (R = 0.88). Firmness in the mouth was well predicted by hardness to touch (R2 = 0.85). The matooke samples were ranked into two sensory clusters by agglomerative hierarchical clustering (AHC).CONCLUSIONThe study showed attribute terms that could be used to describe matooke and also revealed that QDA may be used as a tool during the assessment and selection of new cooking banana hybrids to identify relevant sensory attributes because of its ability to discriminate among the banana hybrids. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Physicochemical and structural characterization of whey protein concentrate–tomato pectin conjugates
Authors: Alancay Matias Miguel , Lobo Manuel Oscar , Samman Norma Cristina 
Published: April 2023

AbstractBACKGROUNDProtein–pectin conjugates, obtained through a controlled Maillard reaction in blends of precursors, are studied for their contribution to improving the emulsifying and thermal properties of proteins. The objective was to obtain a conjugate between whey protein concentrate (WPC) and non‐conventional pectins extracted in acid (acid tomato pectin, ATP) and aqueous medium (water tomato pectin, WTP) from industrialized tomato residues (tomato waste, TW), characterize the conjugates and study their emulsion properties. The Maillard reaction was carried out at 60 °C and 75% relative humidity in blends with 2:1 proportions; 1:1 and 1:2 (mprotein:mpectin) for 3, 6 and 12 days. Conjugates were compared concerning treated and untreated WPC.RESULTSThe WPC–ATP conjugate showed significant increases in color difference (ΔE). The electrophoresis profile of the conjugates showed diffuse bands of molecular weight between 37 and 250 kDa and a reduction in the intensity of bands characteristic of WPC (α‐lactalbumin and β‐lactoglobulin). Thermal analysis showed an increase in the peak temperature and a reduction in the enthalpy change in protein denaturation, associated with the formation of conjugates. The infrared spectroscopy of the conjugates, in the amide III zone (1300–1100 cm−1), indicated an increase in the relative peak area associated with the unfolding and exhibition of the hydrophobic zones of the WPC fraction. The emulsions formulated with the conjugates showed a significant increase in the emulsifying stability index (ESI) (P < 0.05) concerning the treated and untreated WPC emulsions.CONCLUSIONThe formation of conjugates increased the emulsifying properties and improved the thermal stability of WPC, showing an innovative and alternative food ingredient too. © 2023 Society of Chemical Industry.
Synthesis of core‐shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides
Authors: Ahmed Shadi Ali Hassen , Yang YeTong , Li Shuming , Shi Haobin , Qian Linghui , Zhang Jing 
Published: April 2023

The ability to extract peptides and proteins from biological samples with excellent reusability, high adsorption capacity, and great selectivity is essential in scientific research and medical applications. Inspired by the advantages of core‐shell materials, we fabricated a core‐shell material using amino‐functionalized silica as the core. Benzene‐1,3,5‐tricarbaldehyde and 3,5‐diaminobenzoic acid were used as model organic ligands to construct a shell coating by alternately reacting the two monomers on the surface of silica microspheres. The resultant material featured an outstanding capability for the adsorption of cationic peptides, most likely owing to its porous structure, a large number of carboxylic functional groups, and low mass‐transfer resistance. The maximum saturated adsorption capacity reached 833.3 mg/g and the adsorption process took only 20 min. Under optimized adsorption conditions, the core‐shell material was used to selectively adsorb cationic peptides from the tryptic digestive solution of lysozyme and bovine serum albumin, Specifically, the analysis results showed seven cationic peptides in the eluate and twenty anionic peptides in the supernatant, which indicates the efficient trap of most cationic peptides in the digestive solution.
Distributional shifts of wintering midcontinent greater white‐fronted geese
Authors: Moore Callie B. , Osborne Douglas C. , Askren Ryan J. , Carlson Lindsay G. , Brasher Michael G. 
Published: April 2023

AbstractDespite a historically large degree of philopatry to the Gulf Coastal Plains wintering area in the United States and Mexico, the midcontinent population of greater white‐fronted geese (Anser albifrons) has demonstrated changes in their winter distribution in recent decades, warranting investigation into the timing and magnitude of change. We evaluated spatiotemporal patterns in winter band recovery distribution from 1974–2018 and midwinter waterfowl survey counts for midcontinent greater white‐fronted geese. We used an overlap similarity index to compare annual winter band recovery distributions with a historical reference distribution of 1955–1974, followed by a changepoint analysis to assess the timing and magnitude of distributional change. Our analyses revealed a 2‐stage shift in the distribution of winter band recoveries from midcontinent greater white‐fronted geese that occurred following the 1994–1995 season and the 2009–2010 season. As a result, the spatiotemporal distribution of midcontinent greater white‐fronted goose band recoveries can be explained in 3 distinct time eras: the historical era (1974–1995), the transitional era (1995–2010), and the current era (2010–2018). Patterns in midwinter waterfowl survey counts were consistent with changes in winter band recovery distributions, providing further support that midcontinent greater white‐fronted geese have shifted their core winter distribution nearly 750 km northeast over the last 5 decades from the Gulf Coastal Plain to the Mississippi Alluvial Valley. Quantifying the timing and magnitude of this shift in winter distribution of midcontinent greater white‐fronted geese provides clarity to previous patterns in and changes to harvest distribution and could be used to facilitate future decisions regarding harvest management, regulatory frameworks, and habitat conservation planning efforts.
Synthesis of Functionalized Triblock Copolyesters Derived from Lactic Acid and Macrolactones for Bone Tissue Regeneration
Authors: Martínez Cutillas A. , Sanz‐Serrano D. , Oh S. , Ventura F. , Martínez de Ilarduya A. 
Published: April 2023

AbstractSynthetic and functional grafts are a great alternative to conventional grafts. They can provide a physical support and the precise signaling for cells to heal damaged tissues. In this study, a novel RGD peptide end‐functionalized poly(ethylene glycol)‐b‐poly(lactic acid)‐b‐poly(globalide)‐b‐poly(lactic acid)‐b‐poly(ethylene glycol) (RGD‐PEG‐PLA‐PGl‐PLA‐PEG‐RGD) is synthetized and used to prepare functional scaffolds. The PGl inner block is obtained by enzymatic ring‐opening polymerization of globalide. The outer PLA blocks are obtained by ring‐opening polymerization of both, l‐lactide or a racemic mixture, initiated by the α‐ω‐telechelic polymacrolactone. The presence of PGl inner block enhances the toughness of PLA‐based scaffolds, with an increase of the elongation at break up to 300% when the longer block of PGl is used. PLA‐PGl‐PLA copolymer is coupled with α‐ω‐telechelic PEG diacids by esterification reaction. PEGylation provides hydrophilic scaffolds as the contact angle is reduced from 114° to 74.8°. That difference improves the contact between the scaffolds and the culture media. Moreover, the scaffolds are functionalized with RGD peptides at the surface significantly enhancing the adhesion and proliferation of bone marrow‐derived primary mesenchymal stem cells and MC3T3‐E1 cell lines in vitro. These results place this multifunctional polymer as a great candidate for the preparation of temporary grafts.
Radiation‐induced corrosion model for copper‐coated used fuel containers. Part 1. Validation of the bulk radiolysis submodel
Authors: Behazin Mehran , Briggs Scott , King Fraser 
Published: April 2023

AbstractThis paper describes the development of a mixed‐potential model coupling the anodic dissolution of copper to the oxidation and reduction of various radiolysis products, allowing the long‐term prediction of the radiation‐induced corrosion of copper. The overall conceptual model is described, followed by a more detailed discussion of the use of the commercial COMSOL software to predict bulk radiolysis behavior. Various methods are used to validate the COMSOL bulk radiolysis model, including comparison with short‐term experimental data reported in the literature. The underlying principles and assumptions along with the results of the validation procedures are also presented.
Generalized frame operator, lower semiframes, and sequences of translates
Authors: Corso Rosario 
Published: April 2023

AbstractGiven an arbitrary sequence of elements of a Hilbert space , the operator is defined as the operator associated to the sesquilinear form , for . This operator is in general different from the classical frame operator but possesses some remarkable properties. For instance, is always self‐adjoint with regard to a particular space, unconditionally defined, and, when ξ is a lower semiframe, gives a simple expression of a dual of ξ. The operator and lower semiframes are studied in the context of sequences of integer translates of a function of . In particular, an explicit expression of is given in this context, and a characterization of sequences of integer translates, which are lower semiframes, is proved.
Besov estimates for weak solutions of a class of quasilinear parabolic equations with general growth
Authors: Yao Fengping 
Published: April 2023

AbstractIn this paper, we obtain the local higher fractional differentiability regularity estimates in Besov spaces of weak solutions for the quasilinear parabolic equations with general growth under some proper conditions on , and . Moreover, we would like to point out that the results in the present work improve the known results for such parabolic equations.
Low profile conformal phased array with wide scanning range
Authors: Sheng Cao , He Shu‐Cheng , Qu Shi‐Wei , Yang Shiwen 
Published: April 2023

AbstractA linearly polarized conformal phased array antenna with a low profile and a large scanning range is proposed, based on stacked patch antenna element fed by a coupled microstrip line. A backed compact cavity is designed in the antenna element, to reduce the mutual coupling between the elements. The prototype of the proposed conformal array, a conformal array composed of 4 × 4 elements which are axially mounted onto a cylindrical surface, is fabricated and measured, whose profile is as low as 0.072 λh (λh is the free‐space wavelength at the highest operating frequency). The experimental results demonstrate that the array achieves active VSWR below than 2.5 over the frequency band of 1.52–1.77 GHz (15%), within the wide‐scanning ranges of ±70° in the E plane and ±60° in the H plane, and the measured results are in good accordance with the calculation.
Computed tomography‐based radiomics nomogram using machine learning for predicting 1‐year surgical risk after diagnosis of Crohn's disease
Authors: Yao Jiayin , Zhou Jie , Zhong Yingkui , Zhang Min , Peng Xiang , Zhao Junzhang , Liu Tao , Wang Wei , Hu Pinjin , Meng Xiaochun , Zhi Min 
Published: April 2023

AbstractBackgroundIdentifying patients with aggressive Crohn's disease (CD) threatened by a high risk of early onset surgery is challenging.PurposeWe aimed to establish and validate a radiomics nomogram to predict 1‐year surgical risk after the diagnosis of CD, thereby facilitating therapeutic strategies making.MethodsPatients with CD who had undergone baseline computed tomography enterography (CTE) examination at diagnosis were recruited and randomly divided into training and test cohorts at a ratio of 7:3. Enteric phase CTE images were obtained. Inflamed segments and mesenteric fat were semiautomatically segmented, followed by feature selection and signature building. A nomogram of radiomics was constructed and validated using a multivariate logistic regression algorithm.ResultsA total of 268 eligible patients were retrospectively included, 69 of whom underwent surgery 1‐year after diagnosis. A total of 1218 features from inflamed segments and 1218 features from peripheral mesenteric fat were extracted, and reduced to 10 and 15 potential predictors, respectively, to construct two radiomic signatures. By incorporating the radiomics signatures and clinical factors, the radiomics‐clinical nomogram showed favorable calibration and discrimination in the training cohort, with an area under the curve (AUC) of 0.957, which was confirmed in the test set (AUC, 0.898). Decision curve analysis and net reclassification improvement index demonstrated the clinical usefulness of the nomogram.ConclusionsWe successfully established and validated a CTE‐based radiomic nomogram with both inflamed segment and mesenteric fat simultaneously evaluated to predict 1‐year surgical risk in CD patients, which assisted in clinical decision‐making and individualized management.
Choroidal neovascularization removal with photo‐mediated ultrasound therapy
Authors: Wang Mingyang , Nguyen Van Phuc , Singh Rohit , Mossallam Basheer , Yang Xinmai , Wang Xueding , Paulus Yannis M. 
Published: April 2023

AbstractBackgroundAge‐related macular degeneration (AMD) is a major cause of irreversible central vision loss. The main reason for lost vision due to AMD is choroidal neovascularization (CNV). In the clinic, current treatments for CNV include photodynamic therapy, laser photocoagulation, and anti‐vascular endothelial growth factor (VEGF) therapy.PurposeThis study evaluates a novel treatment technique combining synchronized nanosecond laser pulses and ultrasound bursts, namely photo‐mediated ultrasound therapy (PUT) as a potential treatment method for CNV, for its efficacy and safety in the treatment of CNV via the experiments in a clinically‐relevant rabbit model in vivo.MethodsCNV was created by subretinal injection of Matrigel and vascular endothelial growth factor (M&V) in 10 New Zealand white rabbits. Six rabbits were used in the PUT group. In the control groups, two rabbits were treated by laser‐only, and two rabbits were treated by ultrasound‐only. The treatment efficacy was evaluated through fundus photography and fluorescein angiography (FA) longitudinally for up to 4 weeks. Rabbits were sacrificed for histopathology 3 months after treatment to examine the safety of PUT.ResultsThe fluorescein leakage on FA was quantified to longitudinally evaluate treatment outcome. Compared with baseline, the relative intensity index was reduced by 26.57% ± 8.66% at 3 days after treatment, 27.24% ± 6.21% at 1 week after treatment, 27.79% ± 2.61% at 2 weeks after treatment, and 32.12% ± 3.23% at 4 weeks after treatment, all with a statistically significant difference of p < 0.01. The comparison between the relative intensity indexes from the two control groups (laser‐only treatment and ultrasound‐only treatment) did not show any statistically significant difference at all time points. Safety evaluation at 3 months with histopathology demonstrated that the PUT did not result in morphologic changes to the neurosensory retina.ConclusionsThis study introduces PUT for the first time for the treatment of CNV. The results demonstrated good efficacy and safety of PUT to treat CNV in a clinically‐relevant rabbit model. With a single session of treatment, PUT can safely reduce the leakage of CNV for at least 1 month after treatment.