bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of Caspase-dependent Apoptosis in Rat Bone Marrow Mesenchymal
Stem Cells Due to Di-2-Ethylhexyl Phthalate Toxicity was Found
to Arrest the Cell Cycle at the G1 Stage
Authors: Hussein Abnosi Mohammad , Javad Sargolzaei , Zahra Shayeganfar 
Published: January 2023

Background:
Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in polyvinyl chloride
products which is widely utilized. Previously we found, DEHP reduced the viability and proliferation
ability of bone marrow mesenchymal stem cells (BMSCs).

Objective:
In the present study, the mechanism of DEHP toxicity was investigated.

Methods:
Rat BMSCs were cultured up to 3rd passage and their viability was determined after treatment
with 100 and 500 μM of DEHP for 24 and 48 hours. The levels of sodium, potassium, and calcium as
well as induction of apoptosis were investigated. Using flow cytometry, cell cycle analysis was performed
and the expression of genes involved in the cell cycle was evaluated using reverse transcriptase-PCR.
Data were analyzed and p < 0.05 was taken as the level of significance.

Results:
Although the viability and electrolyte level of BMSCs were not affected with 100 μM of DEHP,
this environmental pollution induced caspase-dependent apoptosis in a concentration-dependent manner.
In both of the concentrations, DEHP arrests the cell cycle at the G0/G1 phase, and the expression of Cdk2
and Cdk4 was significantly reduced whereas an over-expression of P53 was observed. However, the expression
of the raf1 gene remained unchanged.

Conclusion:
DEHP induces caspase-dependent apoptosis in BMSCs and arrests the cell cycle due to the
reduction of Cdk2 and Cdk4 expression via over-expression of P53.
Status of α-emitter Radioimmunoconjugates for Targeted Therapy
Authors: Mobina Rabiei , Vaez Alaei Ahmad Reza , Yousefnia Hassan 
Published: January 2023

Abstract:
This minireview describes the global situation of ongoing research and development
and the clinical application of alpha emitter labeled immunoconjugates with various alpha emitters
with an overview of the future trends. The potentially helpful alpha emitter radioisotopes for
medical applications, chelators, and immunomolecules of interest for future alpha
radioimmunotherapy are discussed. Challenges and some suggested future works on chelators are
also presented.
The Antibacterial Effect of Tetracycline-loaded Mesoporous Silica
Nanoparticles in the Gingival Fluid at Implant-abutment Junction:
A Randomized Clinical Trial Study
Authors: Mirzaali Fahimeh , Dizaj Solmaz Maleki , Shahi Shahriar , Memar Mohammad Yousef , Parnia Feridoun 
Published: January 2023

Introduction:
Dental implant failure due to periodontal disease caused by anaerobic
pathogens occurs, especially in the first year of implant placement. The aim of this clinical trial
study was to compare the antibacterial effect of tetracycline gel and gel containing tetracyclineloaded
mesoporous silica nanoparticles (MSNs) in the gingival crevice fluid of the implantabutment
junction as a randomized clinical trial study.

Materials and Methods:
Fourteen patients applying for implants in the posterior mandibular region
were included in the study. During the uncovering session, tetracycline gel and gel containing
tetracycline-loaded MSNs were placed in two implants and no substance was placed in the control
group. Then, in three sessions, including molding, prosthesis delivery, and one month after delivery,
the patient's gingival fluid was sampled and the number of bacteria in the gingival fluid was
measured by colony-forming units (CFU/mL).

Results:
The results of this study showed that in all three stages of sampling, the use of tetracycline
gel and gel containing MSNs loaded with tetracycline significantly reduced the CFU/mL of
gingival crevice fluid compared to the control group. Tetracycline-loaded MSNs gel showed significantly
lower CFU/mL than tetracycline gel. The release of tetracycline from nanoparticles keep
continue for a longer time compared to tetracycline gel.

Conclusion:
The use of nano-based delivery systems containing antibiotics inside the implant
fixture can reduce the bacterial count of the implant-abutment junction and then improve implant
stability.
A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study
Authors: Le Du Katell , Septans Anne-Lise , Maloisel Frédéric , Vanquaethem Hélène , Schmitt Anna , Le Goff Marielle , Clavert Aline , Zinger Marie , Bourgeois Hugues , Dupuis Olivier , Denis Fabrice , Bouchard Stéphane 
Published: January 2023

Background
Evidence regarding the analgesic effect of distraction through immersion in virtual reality (VR) for care-induced pain has been documented in several phase 2 trials, but comparison with standard treatments in large, randomized studies is needed.

Objective
In this open-label, multicenter, randomized, phase 3 trial, we evaluated the safety and efficacy of a novel VR therapy solution for distraction in the context of bone marrow biopsy.

Methods
Bliss is a VR software with 4 imaginary interactive environments in 3 dimensions with binaural sound (head-mounted display). Efficacy regarding pain intensity was evaluated using a visual analog scale (VAS; score from 0 to 10) immediately after the biopsy. Secondary end points were anxiety and tolerance. Modified intention-to-treat analysis was performed.

Results
Overall, 126 patients with previously documented untreated or suspected malignant hemopathy between September 6, 2018, and May 18, 2020, were randomly assigned in a 1:1 ratio to receive pain prevention with a mixture of nitrous oxide/oxygen (MEOPA; n=63) or VR (n=63) before and during the bone marrow biopsy. We excluded 8 patients from the final analysis (3 in the MEOPA group and 5 in the VR group). All patients received local anesthesia (lidocaine) before biopsy. Follow-up was limited to 1 month after the biopsy. Participants’ median age was 65.5 (range 18-87) years, and 54.2% (64/118) of patients were male. The average pain intensity was 3.5 (SD 2.6, 95% CI –1.6 to 8.6) for the MEOPA group and 3.0 (SD 2.4, 95% CI –1.7 to 7.7) for the VR group, without any significant differences in age, sex, center, and hemopathy (P=.26). Concerning anxiety, 67.5% (79/117; fear of pain questionnaire) of the patients were afraid before the biopsy, and anxiety scores were moderate to very high in 26.3% (30/114; revised Spielberger State-Trait Anxiety Inventory questionnaire) of the patients before the biopsy and 9.0% (10/114) after the biopsy for all patients, without a significant difference between the 2 groups (P=.83). Immersion in VR was well tolerated by the majority (54/57, 95%) of patients in the VR group.

Conclusions
The intensity of pain did not significantly differ between both arms. VR was well tolerated, and the satisfaction of patients, nurses, and physicians was very high. VR could be an alternative treatment in case of contraindication or intolerance to MEOPA.

Trial Registration
ClinicalTrials.gov NCT03483194; https://clinicaltrials.gov/ct2/show/NCT03483194
Effectiveness of Digital Guided Self-help Mindfulness Training During Pregnancy on Maternal Psychological Distress and Infant Neuropsychological Development: Randomized Controlled Trial
Authors: Zhang Xuan , Li Yang , Wang Juan , Mao Fangxiang , Wu Liuliu , Huang Yongqi , Sun Jiwei , Cao Fenglin 
Published: January 2023

Background
Maternal psychological distress during pregnancy is associated with unfavorable outcomes in infants. Mindfulness-based interventions (MBIs) can effectively alleviate psychological distress, but there are often barriers to the access of face-to-face interventions.

Objective
This study aimed to investigate the effectiveness of a digital guided self-help (GSH) MBI (GSH-MBI) in reducing maternal psychological distress and improving infant neuropsychological performance.

Methods
This was a randomized controlled trial. We recruited 160 women who were 12 to 20 weeks pregnant and exhibited psychological distress. We randomized them into a digital GSH-MBI group and a control group (usual perinatal care). The digital GSH-MBI consisted of a 6-week intervention through a WeChat mini program, with a daily reminder sent to the participants by a research assistant via WeChat. The primary outcomes consisted of maternal psychological distress, including depression, anxiety, and pregnancy-related anxiety symptoms, which were assessed at 6 time points from baseline to 6 months post partum (only pregnancy-related anxiety symptoms were assessed 3 times during pregnancy). The secondary outcomes were infant neuropsychological outcomes, including temperament and developmental behaviors, which were assessed at 6 weeks and 6 months post partum.

Results
Compared with the control group, the digital GSH-MBI group showed a significant reduction in depression, anxiety, and pregnancy-related anxiety symptoms. In addition, the scores of the digital GSH-MBI group were lower than those of the control group for the 3 types of infant temperament at 6 weeks post partum, including quality of mood, distractibility, and adaptability.

Conclusions
Digital GSH-MBIs are effective in alleviating psychological distress among pregnant women and protecting infant outcomes.

Trial Registration
Chinese Clinical Trial Register ChiCTR2000040717; https://www.chictr.org.cn/showproj.aspx?proj=65376
The Use of Digital Technology for COVID-19 Detection and Response Management in Indonesia: Mixed Methods Study
Authors: Nur Aisyah Dewi , Lokopessy Alfiano Fawwaz , Naman Maryan , Diva Haniena , Manikam Logan , Adisasmito Wiku , Kozlakidis Zisis 
Published: January 2023

Background
The COVID-19 pandemic has triggered a greater use of digital technologies as part of the health care response in many countries, including Indonesia. It is the world’s fourth-most populous nation and Southeast Asia’s most populous country, with considerable public health pressures.

Objective
The aim of our study is to identify and review the use of digital health technologies in COVID-19 detection and response management in Indonesia.

Methods
We conducted a literature review of publicly accessible information in technical and scientific journals, as well as news articles from September 2020 to August 2022 to identify the use case examples of digital technologies in COVID-19 detection and response management in Indonesia.

Results
The results are presented in 3 groups, namely (1) big data, artificial intelligence, and machine learning (technologies for the collection or processing of data); (2) health care system technologies (acting at the public health level); and (3) COVID-19 screening, population treatment, and prevention population treatment (acting at the individual patient level). Some of these technologies are the result of government-academia-private sector collaborations during the pandemic, which represent a novel, multisectoral practice in Indonesia within the public health care ecosystem. A small number of the identified technologies pre-existed the pandemic but were upgraded and adapted for current needs.

Conclusions
Digital technologies were developed in Indonesia during the pandemic, with a direct impact on supporting COVID-19 management, detection, response, and treatment. They addressed different areas of the technological spectrum and with different levels of adoption, ranging from local to regional to national. The indirect impact of this wave of technological creation and use is a strong foundation for fostering future multisectoral collaboration within the national health care system of Indonesia.
Effects of Greenness on Myopia Risk and School-Level Myopia Prevalence Among High School–Aged Adolescents: Cross-sectional Study
Authors: Zhang Chang , Wang Cheng , Guo Xin , Xu Huiyu , Qin Zihao , Tao Liyuan 
Published: January 2023

Background
Myopia is a serious public health issue. High school–aged adolescents in Beijing have an alarming prevalence of myopia. Therefore, determining myopia protective factors is essential. Green space has a certain association with myopia protective factors that can protect against myopia.

Objective
This study aims to examine the effects of green space around schools on individual myopia risk in high school–aged adolescents and the school-level myopia prevalence.

Methods
Green space was measured using the normalized difference vegetation index (NDVI). A total of 13,380 samples of 51 high schools were selected from a 2021 Beijing Municipal Health Commission survey. Adolescent myopia was defined as a spherical equivalent of ≤–1.00 diopters in the worse eye. Generalized linear mixed models with a binomial error structure were used to analyze the effects of the NDVI on personal myopia risk and adjust them by other factors, such as demographics, exposure time, and outdoor exercise. The effects of the NDVI on school-level myopia prevalence with adjusted demographics and the relative position factors of trees were analyzed through quasibinomial regression.

Results
The overall prevalence of myopia was 80.61% (10,785/13,380, 95% CI 79.93%-81.27%). Although with a 0.1 increase in the 500 and 1000 m buffer NDVIs adjusted by demographic and other factors, the high school–aged personal myopia risk significantly dropped by 16% (odds ratio [OR] 0.84, 95% CI 0.73-0.97) and 12% (OR 0.88, 95% CI 0.79-0.99), respectively. However, only the adjusted 500 m buffer NDVI (by demographics and the position of trees) with a 0.1 increase significantly reduced the school-level myopia prevalence by 15% (OR 0.85, 95% CI 0.74-0.98). Subgroup analysis showed that the adjusted effects of the 500 m buffer NDVI are significant in schoolgirls (OR 0.82, 95% CI 0.72-0.93), juniors (OR 0.82, 95% CI 0.72-0.94), the Han nationality (OR 0.84, 95% CI 0.72-0.97), 1-year exposure (OR 0.84, 95% CI 0.71-0.99) and 3-year exposure (OR 0.78, 95% CI 0.65-0.94).

Conclusions
The greenness of a 500 m buffer around schools is associated with a lower personal myopia risk among adolescents and a lower prevalence of myopia in schools. With regard to prevention and control activities, green space within a 500 m buffer around schools is suggested as an independent protective factor for adolescent myopia.
A network meta-analysis of immunotherapy-based treatments for advanced nonsquamous non-small cell lung cancer
Authors: Aggarwal Himani , Ndirangu Kerigo , Winfree Katherine B , Muehlenbein Catherine Elizabeth , Zhu Emily , Tongbram Vanita , Thom Howard 
Published: January 2023

Introduction:
In the absence of head-to-head trials comparing immunotherapies for advanced nonsquamous non-small-cell lung cancer (NsqNSCLC), a network meta-analysis (NMA) was conducted to compare the relative efficacy of these treatments.
Materials & methods:
A systematic literature review of randomized controlled trials evaluating first-line-to-progression and second-line treatments for advanced NsqNSCLC informed Bayesian NMAs for overall survival (OS) and progression-free survival (PFS) end points.
Results:
Among first-line-to-progression treatments, pembrolizumab + pemetrexed + platinum showed the greatest OS benefit versus other regimens and a PFS benefit versus all but three regimens. Among second-line treatments, an OS benefit was seen for atezolizumab, nivolumab and pembrolizumab versus docetaxel.
Conclusion:
Pembrolizumab + pemetrexed + platinum showed the maximum OS benefit in the first-line setting. In the second-line setting, anti-PD-1/anti-PD-L1 monotherapies were better than docetaxel.
Mapping of Farmer Economic Institutions for the Development of Food Crop Farmers Corporations in East Java
Authors: Gunawan  , Ardiansyah  , Tafakresnanto C , Latifah Evy 
Published: January 2023

To increase the reinforcement of farmer capacity, farmer institutions and business capacity become the primary capital for forming farmer corporations. Hence, it is necessary to develop a mapping of agricultural areas based on farmer corporations, especially food commodities in East Java. It combines a series of programs, especially farmer corporations, into one unified whole to align with the Strategic Planning for Regional Development. Mapping of farmer economic institutions (KEP) or farmer group classes to find out which farmer group classes have the potential to become farmer economic institutions. Middle and primary-class farmer groups are a class having the potential to be developed and included as a category of farmer economic institutions (KEP). Accordingly, agricultural areas, which are rice, maize, and soybean areas, can be delineated, having the potential to be developed as a farmer economic institution as a form of farmer corporation in the region. From the research results, it is obtained that farmer economic institutions (KEP) exist in several regencies in East Java. The highest economic institutions were formed in the regency of Tulungagung and Bojonegoro. Some regencies only have one institution that can be formed. The number of formed farmer economic institutions (KEP) can create farmer corporations which are essential for the growth and development of farmer corporations as a basis for improving farmer welfare.
A PEDAGOGIA SOCIAL E A ATUAÇÃO DE PROFESSORES(AS) DA EDUCAÇÃO NÃO FORMAL EM ESCOLAS DOMINICAIS DE ITAMBÉ-BA
Authors: Vieira Klyvia Larissa de Andrade Silva , Novais Sara Silva 
Published: January 2023

Este artigo apresenta um recorte da pesquisa de conclusão de curso. Nossos objetivos foram investigar como se dão as práticas pedagógicas de professores/as que atuam na Educação não formal em Escolas Dominicais de Itambé-BA. Para operacionalização levantamos como objetivos específicos: identificar as práticas pedagógicas dos/as professores/as da Educação não formal em Escolas Dominicais; investigar a formação de professores/as da Escola Dominical; e, refletir sobre os possíveis pontos de contribuição da Pedagogia para a Escola Dominical. A contextualização histórica fundamentou a matriz educacional e educativa desses espaços, na discussão teórica, bem como na compreensão da Pedagogia Social, em suas apropriações e práticas. Os métodos utilizados, neste estudo de caso, foram a análise documental, o questionário e a entrevista semiestruturada. Os resultados demonstram que a Escola Dominical tem uma prática pedagógica coerente, com foco no respeito à faixa etária de cada classe, sendo então uma expressão da Pedagogia Social. Nas considerações apontamos que, ao professor da Escola Dominical, não é exigida uma formação na área de Educação, mas é observada a necessidade de treinamento específico, demonstrando que os conhecimentos formativos da Pedagogia podem favorecer a resolução das dificuldades didático-metodológicas encontradas nessas práticas.
SABERES E PRÁTICAS DE PROFESSORAS LEIGAS: MEMÓRIAS ALFABETIZADORAS QUE SE ENTRECRUZAM
Authors: Andrade Maria Eurácia Barreto de , Estrela Sineide Cerqueira 
Published: January 2023

Este artigo, forjado a partir de uma pesquisa mais ampla, intitulada “Trajetórias, Saberes e Práticas Alfabetizadoras de Professores/as Leigos/as do Interior da Bahia”, vinculada ao Núcleo Carolina Maria de Jesus, objetiva entender as concepções e significados de alfabetização presentes nas narrativas dos professores, identificando como se articulam com os fazeres pedagógicos. Para tanto, os teóricos mobilizados para fundamentar as reflexões são: Almeida (2001), Santos e Haiashida (2017), Manke (2006), dentre outras que contribuíram sobremaneira para melhor compreender as questões que atravessam a temática em pauta. Metodologicamente, este estudo se abastece na pesquisa qualitativa, com ênfase no método da história de vida com uso da entrevista. Os resultados revelam que apesar das professoras considerarem a alfabetização a base fundamental, apresentam uma concepção limitada do processo, expressa no fazer pedagógico de cada uma delas e das atividades selecionadas para ensinar a leitura e a escrita (método sintético), condizentes com a compreensão da época, dos poucos materiais disponíveis para alfabetizar (ABC, cadernos e cartilhas) e das influências recebidas em sua vida escolar, com suas professoras primárias e de um professor mais experiente (Água-marinha). No entanto, apesar das dificuldades enfrentadas, sentem-se orgulhosas pelo trabalho realizado.
Kırsal Kesimin Gelir Durumunun ve Tasarruflarının Belirlenmesine İlişkin Bir Araştırma: İzmir İli Örneği
Authors: SÖNMEZ Seray , ARTUKOĞLU Metin 
Published: January 2023

Amaç: Bu araştırmanın temel amacı, İzmir ilinde kırsal kesimin gelir durumunun ve tasarruflarının belirlenmesidir.
Tasarım/Metodoloji/Yaklaşım: Araştırma İzmir’in Kemalpaşa, Tire ve Kınık ilçelerindeki 126 tarımsal üretici ile yüz yüze anket çalışması yapılmıştır. Araştırma kapsamındaki işletmeler tarımsal gelir gruplarına göre oluşturulan 3 grup altında (0-50.000 TL, 50.000-150.000 TL ve 150.000 TL üzeri) analiz edilmiştir. Üreticilerin demografik ve sosyo-ekonomik özellikleri ortaya konularak, gelir grupları arası farklılık olup olmadığı istatistiksel olarak analiz edilmiştir. Belirli bir dönemde tasarruf yapan ve yapmayan üreticiler belirlenerek, üreticilerin sosyo-ekonomik özellikleri ile tasarruf yapma durumları arasında fark olup olmadığı istatistiksel olarak test edilmiştir. Analizlerin son aşamasında üreticilerin tasarruf yapma amaçlarının belirlenmesi ve üreticilerin tarımsal üretimde karşılaştıkları zorlukların ortaya konulması adına Best-Worst yönteminden faydalanılmıştır.
Bulgular: Araştırma sonuçlarına göre üreticilerin %52,4’ü tasarruf yapabiliyorken, %47.6’sı tasarruf yapamamaktadır. İşletmelerde gelir düzeyine bağlı olarak tasarruf yapma oranlarının da arttığı tespit edilmiştir. Üreticilerin tarımsal gelirleri üzerinde etkili olan en önemli faktör “ülkenin ekonomik durumu” olmuştur. Best-Worst yöntemi analiz sonuçlarına göre, üreticilerin tasarruf kararları almalarında en önemli kriter çocuklarının eğitimi ve geleceği olmuştur.
Özgünlük/Değer: Makroekonomik politikaların tasarrufları arttırıcı yönde geliştirilmesi, özellikle gelir arttırıcı, harcamaları kısıcı uygulamalar yanında tasarrufları değerlendirmede bireyleri teşvik edici uygulamalara gidilmesi önem taşımaktadır. Araştırmanın politika yapıcılara yardımcı olacak bulgular taşıdığı ifade edilebilir.
Jiang Guangci as a Translator of Russian Literature into Chinese
Authors: Liu Zhiqiang , Xiong Hui 
Published: January 2023

The translation activity of the founder of revolutionary Chinese literature, Jiang Guangci, is considered. The novelty of the study is due to the fact that the translations of Russian and Soviet literature by Jiang Guangci are almost not studied in scientific circles. The relevance of the study is due to the importance of building and strengthening Chinese-Russian cultural ties, including in the field of translation of fiction, in which Jiang Guangci was successful in the 20s of the XX century. It has been established that Jiang Guangci’s translations corresponded to his revolutionary ideals, which he embodied in his original works. It is noted that Jiang Guangci's worldview determined his choice of Russian and Soviet works embodying revolutionary ideals for translation. It is shown that his translations received wide support from young people due not only to the content, but also to the simple, understandable language of presentation. The participation of Jiang Guangci in the literary discussion about the translation strategy is presented. Due to his good knowledge of the Russian, he made translations from the original, and not from Japanese translations of Russian works. The authors come to the conclusion that the translation activity of Jiang Guangci has not been sufficiently studied and has prospects for study.