bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chondroblastoma of the patella: a case report of experience in diagnosis and treatment
Authors: Zhao Long , Sun Chao , Qiao Yingchun , He Lu , Zhao Qiu , Ning Guangzhi , Xu Yunqiang 
Published: May 2023

Abstract
Background Patellar chondroblastoma is a relatively rare tumor that occurs in the patella. Chondroblastoma invasion is even rarer, accounting for about 2%, and has a lack of early specific signs. It is a rare benign tumor of cartilage origin, which often occurs in the epiphyseal of long bone in patients aged 12–20 years and has a good prognosis. At present, literature on this condition is limited and lack of relatively complete diagnosis and treatment procedures. This paper reports a case of patellar chondroblastoma that healed well after surgical treatment and systematically summarizes its clinical manifestations, imaging characteristics, differential diagnosis, and treatment methods. For Chondroblastoma of the patella, a disease with a low incidence, a complete and comprehensive diagnosis and treatment process can improve the diagnosis and treatment ability of the disease and improve the patient's satisfaction with the diagnosis and treatment, and finally achieve satisfactory results.Case Description: On February 21, 2022, a 26-year-old male patient was admitted to the hospital due to “discomfort after right knee activity for more than 6 months”. The patient had no obvious inducement to feel swelling of the right lower limb, and no chills, high fever, or paresthesia 6 months prior, and the self-reported pain during the activity was especially significant during flexion. Routinely laboratory testing after admission ruled out contraindications to surgery, and imaging clearly showed lesions in the right patella. According to the patient's signs and related examinations, the diagnosis and treatment team preliminarily diagnosed benign patellar lesions and planned elective surgical treatment. After 6 months of close follow-up and rehabilitation guidance, the function of the affected limb gradually returned to the normal level and no unexpected adverse events occurred during the entire diagnosis and treatment.Conclusions We recommend the following: (I) strive for early treatment to reduce the probability of deterioration and possible pathological fracture; (II) the most commonly used curettage should ensure thorough removal of the lesions; (III) combined internal fixation may have a positive effect on improving the postoperative dependence of patients and encouraging them to perform early functional exercise.
Dual HDAC and PI3K inhibitor CUDC-907 inhibits tumor growth and stem-like properties via suppressing PTX3 in neuroblastoma.
Authors: Hu Yang , Li Mengzhen , Wang Juan , Xu Yanjie , Hong Ye , Zhang Li , Luo Qiu-Yun , Zhen Zijun , Lu Suying , Huang Junting , Zhu Jia , Zhang Yizhuo , Que Yi , Sun Feifei 
Published: May 2023

Abstract
Background Neuroblastoma is one of the common solid tumors in childhood and threatens the lives of children. Patients with advanced or recurrent neuroblastoma have a poor prognosis. CUDC-907, as a novel dual-target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol-3-kinase (PI3K), has been proved to play an anti-tumor role in several tumors. However, whether CUDC-907 has anti-tumor effect in neuroblastoma is still unclear.Methods In vivo and in vitro assays were performed to investigate the anti-neuroblastoma activity of CUDC-907. PTX3 siRNA-expressing and PTX3 overexpressing plasmid were employed to define the underlying mechanisms of CUDC-907. Tumor tissues and clinical information were collected, and immunohistochemical staining was conducted to analysis the relationship between the expression of HDAC1, HDAC2, HDAC3, CD44 and prognosis of patients with neuroblastoma.Results CUDC-907 significantly inhibits proliferation, migration and promotes apoptosis of neuroblastoma cells, down-regulates the expression level of MYCN, as well as PI3K/AKT and MAPK/ERK pathways. Furthermore, CUDC-907 represses the stem-like properties of neuroblastoma cells via inhibiting PTX3, a ligand and upstream protein of cancer stem marker CD44. Immunohistochemical analysis showed that high expression of HDAC1, 2, 3 and CD44 is associated with poor prognosis of neuroblastoma patients.Conclusions These findings indicate that CUDC-907 might be developed into a possible therapeutic approach for neuroblastoma patients.
Machine-learning vs. logistic regression for preoperative prediction of medical morbidity after fast-track hip and knee arthroplasty - a comparative study
Authors: Michelsen Christian , Jørgensen Christoffer Calov , Heltberg Mathias , Jensen Mogens H. , Lucchetti Alessandra , Petersen Pelle B , Petersen Troels , Kehlet Henrik 
Published: May 2023

Abstract
Background: Machine-learning models may improve prediction of length of stay (LOS) and morbidity after surgery. However, few studies include fast-track programs, and most rely on administrative coding with limited follow-up and information on perioperative care. This study investigates potential benefits of a machine-learning model for prediction of postoperative morbidity in fast-track total hip (THA) and knee arthroplasty (TKA).
Methods: Cohort study in consecutive unselected primary THA/TKA between 2014-2017 from seven Danish centers with established fast-track protocols. Preoperative comorbidity and prescribed medication were recorded prospectively and information on length of stay and readmissions was obtained through the Danish National Patient Registry and medical records. We used a machine-learning model based on boosted decision trees with 33 preoperative variables for predicting “medical” morbidity leading to LOS >4 days or 90-days readmissions and compared to a logistical regression model based on the same variables. We also evaluated two parsimonious models, using the ten most important variables in the full machine-learning and logistic regression models. Data collected between 2014-2016 (n:18013) was used for model training and data from 2017 (n:3913) was used for testing.
Model performances were analyzed using precision, area under receiver operating (AUROC) and precision recall curves (AUPRC), as well as the Mathews Correlation Coefficient. Variable importance was analyzed using Shapley Additive Explanations values.
Results: Using a threshold of 20% “risk-patients” (n:782), precision, AUROC and AUPRC were 13.6%, 76.3% and 15.5% vs. 12.4%, 74.7% and 15.6% for the machine-learning and logistic regression model, respectively. The parsimonious machine-learning model performed better than the full logistic regression model. Of the top ten variables, eight were shared between the machine-learning and logistic regression models, but with a considerable age-related variation in importance of specific types of medication.
Conclusion: A machine-learning model using preoperative characteristics and prescriptions slightly improved identification of patients in high-risk of “medical” complications after fast-track THA and TKA compared to a logistic regression model. Such algorithms could help find a manageable population of patients who may benefit most from intensified perioperative care.
Mitigation Measures Protect Groundwater Dependent Ecosystems: Hindsight Evidence
Authors: Chakraborty Debaditya , Sharma Chetan , Basagaoglu Hakan , Yoosefdoost Icen , Chakraborty Debarati , Bertetti F. Paul , Mirchi Ali 
Published: May 2023

Abstract
Overexploitation of groundwater threatens groundwater-bound aquatic and terrestrial biodiversity and ecosystem stability, underscoring the need to devise appropriate mitigation strategies. Yet, there is no hindsight evidence that mitigation measures effectively protect groundwater-dependent habitats. We provide unique and compelling evidence, using artificial intelligence and ground truth data, that mitigation measures can successfully sustain ecologically sensitive spring flows and ensure the sustainability of groundwater-bound threatened and endangered endemic species.
Bile ductal mucosal dysplasia as a risk factor of adenocarcinoma in patients with adenomyomatous hyperplasia of the Vaterian System
Authors: Liu Weizheng , Li Jie , Yang Zhanyu , Jiang Jianan , Zhang Daxu , Lu Wenping 
Published: May 2023

Abstract
Objective The aim of this study was to retrospective analysis of role of ductal glandular dysplasia as a risk factor in the development of carcinoma in adenomyomatous hyperplasia of the Vaterian system(AV).Methods Retrospective collection of data from patients who underwent surgery between January 2005 and December 2021, with a final pathological diagnosis of adenomyomatous hyperplasia (AH). Clinical data and pathological features of AV with or without glandular dysplasia were analyzed.Results Three of seventeen AH cases were associated with carcinoma (18%). Of three cases, two (12%) with the tumor lesions in the mucosal glands adjacent to the AH (cholangiocarcinoma and ampullary carcinoma), and one (6%) with carcinoma developed from AH itself in the ampulla of Vater. All carcinomas had adenomyomatous hyperplasia with nearby mucosal glandular dysplasia (MGD). The incidence of BTC or AC was higher in patients with concurrent AH and MGD compared to AH patients without MGD. The results show tendency toward statistical significance (P = 0.082). This difference was more obvious among AH with severe dysplasia compared to adenomyomatous hyperplasia with mild-moderate dysplasia (P = 0.018).Conclusion This study is the first to find that adenomyomatous hyperplasia of the Vaterian system is associated with ductal carcinoma and ampullary carcinoma. In AV, the mucosal glandular dysplasia is a risk factor for the development of malignancy. The underlying mechanism for carcinogenesis of the Vaterian system could be AH itself or its secretions stimulating mucosal glands hyperplasia, then mucosal glands dysplasia. AH of the Vaterian system may be a precancerous lesion.
The Probabilistic Hesitant Fuzzy TOPSIS Method Based on the Regret Theory and Its Application in Investment Strategy
Authors: Song Chenyang , Xu Zeshui , Hou Jian , Ji Jianchao 
Published: May 2023

Abstract
The TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) is a popular multi-attribute decision making method. However, the increasing uncertain information with probability and the psychological factor of regret aversion of experts in some situations bring new challenges to the application of classic TOPSIS. This paper expands the application of regret theory to the probabilistic hesitant fuzzy environment and proposes the corresponding concepts of utility function, reject-rejoice function and perceived utility value of the probabilistic hesitant fuzzy element (P-HFE). The maximum deviation model under the probabilistic hesitant fuzzy environment is presented to determine the weights of attributes. Based on which, we propose a new probabilistic hesitant fuzzy TOPSIS (PHFTOPSIS) method based on the regret theory. The detailed implementation process of the PHFTOPSIS method based on the regret theory is also provided. Moreover, we apply the proposed PHFTOPSIS method based on the regret theory to the investment strategy. A comparative analysis with traditional TOPSIS and probabilistic hesitant fuzzy weighted averaging (PHFWA) operator is further conducted to illustrate its advantages.
Evaluation of effectiveness and safety of short term low fat ketogenic diet in the reduction of fat mass in patients over 40 years old
Authors: Pastuszak Żanna , Trawińska Lidia , Trawińska Julia , Stępień Jakub 
Published: May 2023

Abstract
Introduction The ketogenic diet is a method of nutrition where, due to the low intake of carbohydrates, the liver is forced to convert fat into fatty acids and ketone bodies and it can be a treatment option for patients who are overweight.Objectives To evaluate effectiveness and safety of short term low fat ketogenic diet in the reduction of fat mass in patients over 40 years old.Patients and methods 107 patients with excess weight or obesity took part in this retrospective study. The first study group consisted of 52 patients over 40 years old and the second study group consisted of 55 patients under 40 years old. All patients were fed with the use of a nasogastric tube with a nutrition mixture consisting of 90% protein and only 0.7% carbohydrates for 10 days. Parameters such as weight, BMI, fat and muscle mass, as well chest, waist and hip circumference were measured before and after treatment.Results Statistical analysis revealed that there was a statistically significant reduction of BMI and fat mass as well as chest, waist and hip circumference in both groups after ketogenic therapy. In the first study group, the reduction of body mass was observed from 107.17 kg before therapy to 100.42 kg after treatment while in the second group from 104.62 kg to 98.16 kg.Conclusion Short term low fat and low carbohydrate diet seems to be an effective and safe treatment option for patients with overweight or obesity.
A mine sweeping game to predict large-scale earthquakes
Authors: Fu Yu-Fan , Zhang Zhong-Wei , Yang Xin-Yue , Xie Lin-Bei , Jiang Si-Cong , Zeng Jian , Chen Yang-Er , Yuan Ming , Yuan Shu 
Published: May 2023

Abstract
After a triggering earthquake (TGE) occurs on one side of a plate boundary, it often produces a vertical-downward shift, which will cause a vertical-upward shift on the other side of the plate boundary, where after a long period of time, the stress may be re-accumulated and a large earthquake (triggered earthquake, TDE) may occur. The larger the magnitude of the TGE is, the greater the distance between the TGE and TDE will be, and the longer the time interval between the TGE and TDE will be. The correlations between the magnitude and distance and between the magnitude and time interval were calculated. Based on the regression equations, we verified 86 large earthquakes over the past 100 years with magnitudes greater than 6.6. The prediction process is similar to a mine sweeping game. Although only 63%–88% of large-scare earthquakes can be accurately predicted, earthquakes of M ≥ 9.0 and earthquakes that have caused significant casualties had all met our model with a prediction accuracy of 100 km and 3 days.
Impact of body mass index on mortality in middle-aged Koreans: A prospective cohort study based on a Health Examinees study
Authors: Cho Sooyoung , Shin Aesun , Choi Ji-Yeob , Lee Jong-Koo , Kang Daehee 
Published: May 2023

Abstract
Background Obesity is the major cause of chronic diseases and the leading cause of mortality. We aimed to assess the impact of obesity on mortality in middle-aged Koreans using data from a Health Examinees study.Methods We used data from 39,689 men and 76,272 women who had complete information on body size and gave informed consent for the linkage of their data with the national death certificate data. Cox proportional hazard model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of body mass index (BMI) for all-cause, cardiovascular, and cancer mortality. The educational level and habits of cigarette smoking, alcohol consumption, and regular physical activity were adjusted. The menopausal status was additionally adjusted in women.Results We found increased risks of all-cause mortality among those with a BMI of < 18.5 kg/m2 (adjusted HRs [95% CIs]: men, 2.24 [1.73–2.91]; women, 1.47 [0.98–2.22]) and 18.0–< 21 kg/m2 (men, 1.18 [1.00–1]; women, 1.23 [1.01–1.50]) than in those with a BMI of 21–< 23 kg/m2. We also observed that men with BMIs of 23–< 25 kg/m2 (0.85 [0.74–0.97]) and 25.0–26.9 kg/m2 (0.87 [0.75-1.00]) had decreased risks of all-cause mortality.Conclusion This large prospective study found significant associations between BMI and mortality. Especially, being underweight was associated with an increased risk of mortality in both sexes.
Immune-related adverse reactions (irAEs) are closely related to the patient's mental status in advanced non-small cell lung cancer
Authors: Yang Jiaxin , Li Lijun , Li Ning , Xue Dinglong , Men Kaiya , Jiang Hao , Meng Qingwei , Zhang Shuai 
Published: May 2023

Abstract
Purpose Patients with lung cancer often develop negative psychology, particularly anxiety and depression, which often leads to reduced quality of life, shorter survival time and increased mortality. The main aim of this study was to explore whether anxiety and depression contribute to a greater risk of irAEs in patients treated with combined ICIs.Methods A total of 317 lung cancer patients receiving combined immunotherapy were included in the Cancer Hospital of Harbin Medical University from September 2018 to May 2022. The Hospital Anxiety and Depression Scale (HADS) was used to measure the anxiety and depression of patients prior to treatment with the combined ICIs. The irAEs were assessed 1–3 days after each immunotherapy treatment and recorded according to the Common Terminology Criteria for Adverse Events version 5.0. Cardinality tests, univariate and multivariate logistic regression models were used to identify risk factors for the occurrence of irAEs.Results The prevalence of anxiety and depressive states before patients received the combined ICIs was 36.6% and 37.5% respectively. Multivariate logistic regression analysis showed that anxiety (P < 0.01, OR = 5.169) and depression (P < 0.01, OR = 3.766) were identified to increase the risk of irAEs. Patients with anxiety (P < 0.01, OR = 1.274) and depression (P < 0.01, OR = 1.098) were more likely to have a higher number of irAEs.Conclusion We demonstrate that patients' anxiety and depressive states prior to receiving combined ICI therapy do increase the probability of irAEs and have a high chance of leading to more irAEs in patients.
Genome-wide identification of SrbHLH transcription factors highlight its potential role in rebaudioside A (RA) biosynthesis in Stevia rebaudiana
Authors: Li Yuping , Qiu Yuan , Xu Xin , Luo Ming 
Published: May 2023

Abstract
Stevia rebaudiana Bertoni is a valuable medicinal plant and an important source of natural sweetener, steviol glycosides (SGs), with rebaudioside A (RA) being one of the main components of SGs. bHLH genes play a crucial role in plant development and secondary metabolism. In this study, a total of 159 SrbHLHgenes were identified from the S. rebaudiana genome, and each gene was named based on its chromosome location. The SrbHLH proteins were then clustered into 18 subfamilies through phylogenetic analysis. The classification of the SrbHLH family was further supported by the analysis of conserved motifs and gene structure. Chromosomal location and gene duplication events of SrbHLH genes were also studied. Moreover, based on the RNA-Seq data of different tissues of S. rebaudiana, 28 SrbHLHs were found to be co-expressed with structural genes involved in RA biosynthesis. The expression pattern of candidate SrbHLH genes was confirmed by qPCR. Finally, dual luciferase reporter assays (DLAs) and subcellular localization analysis verified SrbHLH22, SrbHLH111, SrbHLH126, SrbHLH142, and SrbHLH152 as key regulators of RA biosynthesis. This study provides new insights into the function of SrbHLHs in regulating SGs biosynthesis and lays the foundation for future applications of SrbHLH genes in molecular breeding of S. rebaudiana.
SARS-CoV-2 shifts transcription of host gene to increase Spike acylation and boost infectivity
Authors: Goot F. van der , Mesquita Francisco Sarmento , Abrami Laurence , Bracq Lucie , Panyain Nattawadee , Mercier Vincent , Kunz Béatrice , Chuat Audrey , Carlevaro-Fita Joana , Trono Didier 
Published: May 2023

Abstract
SARS-CoV-2 infection requires Spike protein mediating fusion between the viral and cellular membranes. The fusogenic activity of Spike requires its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observations indicate that SARS-CoV-2 infection augments the S-acylation of Spike when compared to transfection. Here, we find that SARS-CoV-2 infection triggers a change in the transcriptional start site of the zddhc20 gene, both in cells and in an in vivo infection model, resulting in a 67-amino–acid-long N-terminally extended protein with 37-times higher Spike acylating activity, leading to enhanced viral infectivity. Furthermore, we observed the same induced transcriptional change in response to other challenges, such as chemically induced colitis, indicating that SARS-CoV-2 hijacks an existing cell damage response pathway to generate more infectious viruses.
Effect of Functional Training on Fundamental Motor Skills Among Children: A Systematic Review
Authors: Zhang Dong , Soh Kim Geok , Chan Yoke Mun , Bashir Marrium , Xiao Wensheng 
Published: May 2023

Abstract
Background Functional training is an exercise program to enhance physical abilities such as balance, coordination, agility, and power. The effectiveness of functional training in enhancing physical fitness and motor skills has been established through its use in rehabilitation treatment and sports training. However, current systematic reviews have not considered the impact of functional training on fundamental motor skills. This review aimed to examine the effect of functional training on the fundamental motor skills of children.Methods Following PRISMA guidelines, a search was conducted in six databases: PubMed, Scopus, ProQuest, Web of Science, EBSCOhost, and SPORT Discus, from January 2000 to December 2021.Results The search yielded 1451 papers, of which only 24 satisfied all inclusion and exclusion criteria. Significant improvements were found in the three main areas of FMS, namely, locomotor skills (n = 15), balance skills (n = 9), and objective control skills (n = 2), as well as general physical fitness (n = 14).Conclusions This systematic review shows that functional training effectively improves children’s fundamental motor skills. It is in accordance with the scientific theory of functional training. Closed kinetic chain exercises connect joints and muscle groups to work together, making movement and training safer and more effective. Furthermore, the study outcomes provide valuable insight into the potential benefits of functional training for children. It may help inform physical education programs and provide guidance on how to best use functional training to enhance children’s fundamental motor skills.
WITHDRAWN: A Novel Mutation in MYO18B Gene Accompanied By Sensory Neuropathy
Authors: Eroğlu Arzu , Çaksen Hüseyin , Topçu Meral 
Published: May 2023

Abstract
Different genetic heterogeneity of Klippel–FeilSyndromevariants has been identified. One of those variants is Klippel–Feil Syndrome 4 (KFS+; MIM #616549), which is caused by the mutation in the MYO18B gene of the autosomal recessively inherited 22q12 chromosome. About 10 relevant cases have been identified in the literature. As genetic research gains popularity, it is likely that variants will emerge as well. In this sense, we introduce a case characterized by the identification of a recent homozygous missense mutation [c.2147G > A (p.R716Q)] in the MYO18B gene accompanied by Sensory Neuropathy.