bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shedding light on the X(3930) and X(3960) states with the $$B^- \rightarrow K^- J/\psi \omega $$ reaction
Authors: Abreu L. M. , Albaladejo M. , Feijoo A. , Oset E. , Nieves J. 
Published: April 2023

AbstractWe have studied the contribution of the state X(3930), coming from the interaction of the $$D \overline{D}$$

D

D
¯

and $$D^{+}_s D^{-}_s$$

D
s
+

D
s
-

channels, to the $$B^- \rightarrow K^- J/\psi \omega $$

B
-

→

K
-

J
/
ψ
ω

decay. The purpose of this work is to offer a complementary tool to see if the X(3930) state observed in the $$D^+ D^-$$

D
+

D
-

channel is the same or not as the X(3960) resonance claimed by the LHCb Collaboration from a peak in the $$D^{+}_s D^{-}_s$$

D
s
+

D
s
-

mass distribution around threshold. We present results for what we expect in the $$J/\psi \omega $$

J
/
ψ
ω

mass distribution in the $$B^- \rightarrow K^- J/\psi \omega $$

B
-

→

K
-

J
/
ψ
ω

decay and conclude that a clear signal should be seen around $$3930\,\text {MeV}$$

3930

MeV

. At the same time, finding no extra resonance signal at $$3960\,\text {MeV}$$

3960

MeV

would be a clear indication that there is not a new state at $$3960\,\text {MeV}$$

3960

MeV

, supporting the hypothesis that the near-threshold peaking structure peak in the $$D^{+}_s D^{-}_s$$

D
s
+

D
s
-

mass distribution is only a manifestation of a resonance below threshold.
Non canonical polarizations of gravitational waves
Authors: Bondani Stefano , Cacciatori Sergio Luigi 
Published: April 2023

AbstractWe hereby propose an alternative and additional angle on the nature of gravitational waves (GWs), postulating the theoretical and experimental possibility that GWs carry a deformation of the time component of spacetime, other than the spatial one. By explicitly working outside of the transverse-traceless gauge, we propose how events with well-defined time duration, when hit by a GW, would consequently be expected to show a difference in their characteristic time, as measured from the rest frame of an outside observer, whose clock is to remain unaffected by the GW. This constitutes a theoretically viable way in the sense of detecting the passing of the wave itself and may prove relevant as a standalone method for GWs detection other than laser interferometers, or as well be implemented as a complementary but independent system of signal triggering, improving the statistical significance of existing methods. A simple but physically realistic scenario in which the appropriate conditions for the generation and detection of GWs with time dilation are met is presented, along with the conceptual design of an experimental detector.
Superimposed brittle structures in polyorogenic contexts: Variscan and Alpine faults in the Duje Valley (Picos de Europa, Cantabrian Mountains, NW Spain)
Authors: Gonzalo-Guerra B. , Heredia N. , Farias P. , García-Sansegundo J. , Martín-González F. 
Published: April 2023

Abstract

Detailed geological mapping of a highly fractured Paleozoic (pre-Permian) basement and the scarce outcrops of overlying Permian–Mesozoic cover in the surroundings of the Duje Valley (Picos de Europa Unit, Cantabrian Mountains, NW Spain), together with new field data, have allowed the separation of four genetic fault sets in a polyorogenic area, affected by the Variscan and Alpine cycles. These fault sets are, from oldest to youngest: Variscan thrusts (late Carboniferous), late Variscan strike-slip faults (late Carboniferous–earliest Permian), Alpine normal faults (Permian–Mesozoic) and Alpine reverse faults (Cenozoic). A structural analysis is reported here, based on the joint use of geometric, kinematic and deformational features, cross-cutting and tectono
–
sedimentary relationships between the structures. This analysis has allowed the recognition and full characterization of the four fault sets. These types of structural analyses are useful for unravelling complex tectonic histories in regions where massive limestone lithologies make reconstructing the timing of fault activity difficult, especially if the basement is affected by late deformation events that are not recorded by cover outcrops.
Compared to Fishmeal, Dietary Soybean Meal Improves the Reproductive Performance of Female Yellow Catfish (Pelteobagrus fulvidraco) Broodstock
Authors: Chen Zheng , Fei Shuzhan , Liu Cui , Duan Yuanhui , Liu Haokun , Han Dong , Jin Junyan , Yang Yunxia , Zhu Xiaoming , Xie Shouqi 
Published: April 2023

To investigate the effects of different dietary protein sources on the reproductive performance of female broodstock, yellow catfish (Pelteobagrus fulvidraco) were fed with three experimental diets using fishmeal (FM), soybean meal (SBM), and rapeseed meal (RSM) as main protein sources, respectively. Females (initial weight:

64.56
±
0.45

g) were distributed into 9 net cages for feeding trial. Results indicated that 30% dietary SBM improved the reproductive performance for higher gonadosomatic index (GSI), relative fecundity, total egg production, egg diameter, and hatching rate. In addition, SBM and RSM diets resulted in higher estradiol (E2), vitellogenin (VTG), luteinizing hormones (LH), and lower follicle-stimulating hormone (FSH) and testosterone (T) in plasma (

P
<
0.05

) of female broodstock. Dietary SBM and RSM also resulted in lower mesenteric fat index (MFI), plasma total cholesterol (TC), plasma total bilirubin (T-Bil) contents, and gonadal cortisol concentrations, while dietary SBM downregulated the transcription levels of steroidogenesis-related proteins by negative feedback (

P
<
0.05

). The results demonstrated that dietary SBM and RSM could promote sex steroid hormone and VTG biosynthesis and showed hypocholesterolemic effects. Besides, 30% dietary SBM inclusion could improve the reproductive performance of female yellow catfish broodstock.
The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis
Authors: Huynh Khanh Quang , Le Anh Tuan , Phan Thang Thanh , Ho Toan Trong , Pho Suong Phuoc , Nguyen Hang Thuy , Le Binh Thanh , Nguyen Thuc Tri , Nguyen Son Truong 
Published: April 2023

Background. MicroRNA-1246 (miR-1246), an oncomiR that regulates the expression of multiple cancer-related genes, has been attracted and studied as a promising indicator of various tumors. However, diverse conclusions on diagnostic accuracy have been shown due to the small sample size and limited studies included. This meta-analysis is aimed at systematically assessing the performance of extracellular circulating miR-1246 in screening common cancers. Methods. We searched the PubMed/MEDLINE, Web of Science, Cochrane Library, and Google Scholar databases for relevant studies until November 28, 2022. Then, the summary receiver operating characteristic (SROC) curves were drawn and calculated area under the curve (AUC), diagnostic odds ratio (DOR), sensitivity, and specificity values of circulating miR-1246 in the cancer surveillance. Results. After selection and quality assessment, 29 eligible studies with 5914 samples (3232 cases and 2682 controls) enrolled in the final analysis. The pooled AUC, DOR, sensitivity, and specificity of circulating miR-1246 in screening cancers were 0.885 (95% confidence interval (CI): 0.827-0.892), 27.7 (95% CI: 17.1-45.0), 84.2% (95% CI: 79.4-88.1), and 85.3% (95% CI: 80.5-89.2), respectively. Among cancer types, superior performance was noted for breast cancer (

AUC
=
0.950
,
DOR
=
98.5

) compared to colorectal cancer (

AUC
=
0.905
,
DOR
=
47.6

), esophageal squamous cell carcinoma (

AUC
=
0.757
,
DOR
=
8.0

), hepatocellular carcinoma (

AUC
=
0.872
,
DOR
=
18.6

), pancreatic cancer (

AUC
=
0.767
,
DOR
=
12.3

), and others (

AUC
=
0.887
,
DOR
=
27.5
,
P
=
0.007

). No significant publication bias in DOR was observed in the meta-analysis (funnel plot asymmetry test with

P
=
0.652

;

skewness

value
=
0.672

,

P
=
0.071

). Conclusion. Extracellular circulating miR-1246 may serve as a reliable biomarker with good sensitivity and specificity in screening cancers, especially breast cancer.
Designing Enactive Co-Presence: Second-Order Simulation of Empathy for Artificial Humans in Narrative Contexts
Authors: Tikka Pia , McNamara Robert G. , Gerry Lynda Joy , Kosunen Ilkka , Kaipainen Mauri 
Published: April 2023

Abstract
Human interactions with human-like Computer-Generated Others (CGOs) have continued to become more prevalent in the rush to technologize societies. As such, the need for close analysis of mediative dynamics between humans and CGOs has become compelling. Relying on the theoretical framework of embodied enactive cognition, this paper will discuss designing human empathetic experiences of co-presence with CGOs. We propose a two-level idea of enactive simulation: the assumption of the first-order simulation (human simulating other) is built on the holistic assumption that humans understand others thanks to shared physical embodiment and enactive situatedness, while second-order simulation (designer simulating human simulating other) is the cognitive-affective means of the designer of human–machine encounters to apply their own first-order experiences to simulate the simulation of the Experiencer. Our key assumption is that context is the defining component of co-presence, thereby allowing experimental situations of co-presence to be contextualized by means of mediated narratives. The case study experiment, Booth, designed to model affective-cognitive experiences of co-presence at encounters of human Experiencers with two artificial asylum seekers, allowed us to identify different factors of the dynamics influencing the experience of empathy and the ensuing decisions concerning asylum, in particular, the contextualizing narrative.
Eyes over stomach: companion dogs choose the larger quantity by sight, irrespective of the actual reward eaten
Authors: Loconsole Maria , Regolin Lucia , Marliani Giovanna , Mattioli Michela , Pietschmann Elena , Accorsi Pier Attilio , Normando Simona 
Published: April 2023

Abstract
Domestic dogs tested in a free-choice task between two sets of food prefer that of a larger quantity. A recent study pointed out the critical role of the first trial. Dogs succeeded only after being allowed at least once to eat the selected food. Here we explore the importance of the actual experience of consuming the selected reward on dogs’ capability to redirect their choice to solve numerical discriminations. Dogs tested in the 2 vs 4 and 1 vs 8 comparisons could never consume the quantity selected but always obtained a single dogs’ treat. Despite never experiencing a difference in the eaten quantity, dogs discriminated between the two sets, preferring the larger. Whereas they behaved at chance at first choice, they successfully redirected their preference toward the larger set already on their second trial. We discuss our results in terms of motivational biases toward the larger quantity that can bear relevant ecological value.
Al-Muʾtaman ibn Hūd in Context: Kingship and Philosophy in al-Andalus (10th-11th Centuries)
Authors: Forcada Miquel 
Published: April 2023

Abstract
In the Islamic world, the idea of the “philosopher-king” became a relevant theme particularly from the tenth century onwards. Al-Fārābī, the political philosopher of Islam par excellence, discussed the perfect city ruled by the philosopher-king along the lines of Plato. Although al-Fārābī’s political thinking is susceptible to various interpretations, it contains a key idea that was most particularly significant for his readers: that human beings must seek perfection and the utmost happiness in theoretical life, but that utmost perfection and felicity are only possible within the virtuous city ruled by the philosopher-king. In al-Andalus, al-Muʾtaman ibn Hūd, king of Saragossa (r. 474/1081-478/1085) seems to follow these ideals. Al-Muʾtaman was a philosopher and a mathematician when he ascended the throne. Given that the scholars of his time and of the generations that followed criticised him for his religious beliefs and philosophical opinions, it may well be that he attempted to rule as a philosopher-king. This article presents, on the one hand, a study of the personal and intellectual biographies of al-Muʾtaman, and on the other, an analysis of the relationship between the rational sciences and the society that generated a king of his calibre, focusing above all on its intrinsic complexity and its roots (the intellectual legacy of Umayyad Cordova). In this way, the article provides insights into the relationship between knowledge and power and, more particularly, into the legitimising role of secular knowledge inside religiously oriented societies.
Hasan Hanafi and ‘The Indissoluble Bond’ between Heritage and Renewal
Authors: Puig Montada Josep 
Published: April 2023

Abstract
Hassan Hanafi, (1935-2021), graduated in 1956 from Cairo University and in October of the same year he started his doctoral studies at the Sorbonne in Paris. This was the beginning of his lifelong project on ‘Heritage and Renewal’ aiming at renewing Islam by means of reworking its legacy. This article analyses the milestones of his project, represented by an prolific intellectual production, and organized in a triangular form. The base of the triangle is the science of Koranic exegesis, and the two sides are the analysis of the Ancient Muslim heritage and that of the Western impact.
Sensing the (digital) pulse. Future steps for improving the secondary use of data for research in Switzerland
Authors: Martani Andrea , Geneviève Lester Darryl , Wangmo Tenzin , Maurer Julia , Crameri Katrin , Erard Frédéric , Spoendlin Julia , Pauli-Magnus Christiane , Pittet Valerie , Sengstag Thierry , Soldini Emiliano , Hirschel Bernard , Borisch Bettina , Kruschel Weber Cornelia , Zwahlen Marcel , Elger Bernice Simone 
Published: April 2023

Introduction Ensuring that the health data infrastructure and governance permits an efficient secondary use of data for research is a policy priority for many countries. Switzerland is no exception and many initiatives have been launched to improve its health data landscape. The country now stands at an important crossroad, debating the right way forward. We aimed to explore which specific elements of data governance can facilitate – from ethico-legal and socio-cultural perspectives – the sharing and reuse of data for research purposes in Switzerland. Methods A modified Delphi methodology was used to collect and structure input from a panel of experts via successive rounds of mediated interaction on the topic of health data governance in Switzerland. Results First, we suggested techniques to facilitate data sharing practices, especially when data are shared between researchers or from healthcare institutions to researchers. Second, we identified ways to improve the interaction between data protection law and the reuse of data for research, and the ways of implementing informed consent in this context. Third, we put forth ideas on policy changes, such as the steps necessary to improve coordination between different actors of the data landscape and to win the defensive and risk-adverse attitudes widespread when it comes to health data. Conclusions After having engaged with these topics, we highlighted the importance of focusing on non-technical aspects to improve the data-readiness of a country (e.g., attitudes of stakeholders involved) and of having a pro-active debate between the different institutional actors, ethico-legal experts and society at large.
The “vicious circle” of chronic cough: the patient experience – qualitative synthesis
Authors: Brindle Kayleigh , Morice Alyn , Carter Natalie , Sykes Dominic , Zhang Mengru , Hilton Andrea 
Published: April 2023

AimThe aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough.MethodsA systematic search was conducted to identify all studies that used qualitative methodology to report on the experiences of adults living with chronic cough. A thematic synthesis of the first-hand narratives was undertaken. Key themes in relation to personal perspectives and experiences of living with chronic cough were identified and grouped into analytical themes.ResultsSix studies met the inclusion criteria. The thematic synthesis generated three analytical themes: 1) “It's just a cough”; 2) “Constant cough and constant worry”; and 3) “No light at the end of the tunnel”, highlighting the biopsychosocial nature of chronic cough. The synthesis highlights chronic cough as a heterogeneous experience that may appear idiosyncratic, completely consuming the lives of those living with it.ConclusionThis is to our knowledge the first qualitative synthesis reporting on the perceptions and experiences of adults living with chronic cough. Our review draws attention to the paucity of literature that utilises qualitative methodology to explore the experience of living with chronic cough. We highlight the missing voice of people living with chronic cough in the contemporary literature. There is now a requirement for research exploring the narratives of those living with chronic cough, to gain an understanding of the condition beyond simple quantification.
Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway
Authors: Li Yunchao , Wang Xiaoxiao , Pan Changyu , Yuan Hui , Li Xinyi , Chen Zejun , He Haoyu 
Published: April 2023

AbstractBackgroundSarcopenia and osteoporosis are common diseases that predominantly affect older individuals. The interaction between muscle and skeleton exerts pivotal roles in bone remodeling. This study aimed to explore the function of myoblast-derived exosomal Prrx2 in osteogenic differentiation and its potential mechanisms.MethodsExosomes were isolated from myogenic differentiated C2C12 cells. qRT-PCR and Western blotting were used to determine target molecule expression. Osteogenic differentiation of BMSCs was evaluated by Alizarin red staining, ALP activity and levels of OCN, OPN, RUNX2, and BMP2. Dual-luciferase reporter assay, RIP, and ChIP assays were performed to verify the interaction between molecules. The nuclear translocation of YAP1 was observed by immunofluorescence staining. In vivo osteoporotic model was established by ovariectomy in mice. Bone loss was examined using HE staining.ResultsPrrx2 expression was elevated in myogenic differentiated C2C12 cells and their exosomes. Myoblast-derived exosomal Prrx2 enhanced osteogenic differentiation of BMSCs. Delivering exosomal Prrx2 directly bond to MIR22HG promoter and promoted its transcription and expression. MIR22HG enhanced expression and nuclear translocation of YAP via sponging miR-128, thus facilitating BMSC osteogenic differentiation. Knockdown of exosomal Prrx2 suppressed osteogenic differentiation, which could be abolished by MIR22HG overexpression. Similarly, miR-128 inhibitor or YAP overexpression reversed the inhibitory effect of MIR22HG depletion or miR-128 mimics on osteogenic differentiation. Finally, myoblast-derived exosomal Prrx2 alleviated osteoporosis in mice via up-regulating MIR22HG and activating the Hippo pathway.ConclusionMyoblast-derived exosomal Prrx2 contributes to transcriptional activation of MIR22HG to activate YAP pathway via sponging miR-128, thereby facilitating osteogenic differentiation of BMSCs.
Current advances in nanodrug delivery systems for malaria prevention and treatment
Authors: Kekani Linda N. , Witika Bwalya A. 
Published: April 2023

AbstractMalaria is a life-threatening, blood-borne disease with over two hundred million cases throughout the world and is more prevalent in Sub-Saharan Africa than anywhere else in the world. Over the years, several treatment agents have been developed for malaria; however, most of these active pharmaceutical ingredients exhibit poor aqueous solubility and low bioavailability and may result in drug-resistant parasites, thus increasing malaria cases and eventually, deaths. Factors such as these in therapeutics have led to a better appreciation of nanomaterials. The ability of nanomaterials to function as drug carriers with a high loading capacity and targeted drug delivery, good biocompatibility, and low toxicity renders them an appealing alternative to conventional therapy. Nanomaterials such as dendrimers and liposomes have been demonstrated to be capable of enhancing the efficacy of antimalarial drugs. This review discusses the recent development of nanomaterials and their benefits in drug delivery for the potential treatment of malaria.
How elastic is labor demand? A meta-analysis for the German labor market
Authors: Popp Martin 
Published: April 2023

AbstractThe own-wage elasticity of labor demand measures the effect of higher wages on firms’ demand for labor and, thus, determines the impact of supply shocks, minimum wages, and collective wage agreements on the labor market. I carry out a comprehensive meta-analysis to shed light on the nature of this parameter, leveraging 705 elasticity estimates from 105 studies on the German labor market. The average elasticity is −0.43, but entails important heterogeneity: Labor demand turns out particularly elastic for low- and high-skilled workers, in the long run, and for internationally operating firms. While empirical designs that address endogeneity deliver more negative elasticities, the analysis does not support any systematic differences by region or by margin of adjustment.
Validation of genetic variants from NGS data using deep convolutional neural networks
Authors: Vaisband Marc , Schubert Maria , Gassner Franz Josef , Geisberger Roland , Greil Richard , Zaborsky Nadja , Hasenauer Jan 
Published: April 2023

AbstractAccurate somatic variant calling from next-generation sequencing data is one most important tasks in personalised cancer therapy. The sophistication of the available technologies is ever-increasing, yet, manual candidate refinement is still a necessary step in state-of-the-art processing pipelines. This limits reproducibility and introduces a bottleneck with respect to scalability. We demonstrate that the validation of genetic variants can be improved using a machine learning approach resting on a Convolutional Neural Network, trained using existing human annotation. In contrast to existing approaches, we introduce a way in which contextual data from sequencing tracks can be included into the automated assessment. A rigorous evaluation shows that the resulting model is robust and performs on par with trained researchers following published standard operating procedure.