bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Effect of Battery Voltage Drop on Light Intensity on LED and Hologen Type Main Lights in Gentayu UNDIP Electric Cars to Get Good Lighting
Authors: Setiyawan Trio , Kristiawan Timotius Anggit 
Published: June 2023

<p><strong>Abstrak</strong><strong> - </strong><strong>The Gentayu UNDIP electric car requires a lighting system, especially the main lighting system, namely the headlights which must have sufficient light but must be economical in power consumption, because the power used uses a battery that is separate from the main battery for propulsion. So that with a separate battery, the available power is limited, for charging the battery a separate mechanism is made and it can be charged simultaneously with charging the main battery for the Gentayu UNDIP electric car. we will try to do a special analysis of the intensity of light in the lighting system of the main lighting system, to get data on the effect of battery power on light intensity. The test was carried out by observing the decrease in light intensity on two types of lamps, namely LED lamps and halogen lamps. 1x10 Lux every 15 minutes with an average voltage drop of 0.06 volts for every 15 minutes. Meanwhile, for halogen type lamps, the average decrease in light intensity is 6x10 Lux every 15 minutes with a voltage drop of 17 volts, so even though the use of LED type lamps has low power consumption in its use, but a decrease in light intensity when used for a long time cannot be avoided, so it is necessary to make a mechanism for the Gentayu UNDIP electric car so that the battery voltage is maintained when the lighting electrical system is used</strong><strong>.</strong><strong></strong></p><p><strong> </strong></p><script id="stacks-wallet-provider" type="text/javascript" src="chrome-extension://ldinpeekobnhjjdofggfgjlcehhmanlj/inpage.js"></script><script id="stacks-wallet-provider" type="text/javascript" src="chrome-extension://ldinpeekobnhjjdofggfgjlcehhmanlj/inpage.js"></script>
ANALISIS WACANA MODEL THEO VAN LEEUWEN PADA BERITA TIPIKOR DALAM RUBRIK POLITIK DAN HUKUM SURAT KABAR HARIAN KOMPAS
Authors: Rofii Afif , Yuniarti Lisa 
Published: June 2023

The purpose of this research is to describe strategies used by journalists in marginalizing corruptors available in law and political rubrics of Kompas Daily examined using a discourse analysis with Theo Van Leeuwen model. This research is conducted using a descriptive-qualitative method. The research data are in the forms of transcriptions of Kompas Daily discourse texts available in law and political rubrics. Data are taken from KompasDaily on editions of 29 may 2013 – 7 June 2013. Based on the data analysis and discussion, it can be concluded that due to the news reports on corruption crime cases, the journalists tend to marginalize corruptors. First, the exclusion strategies consist of (1) passiveness and (2) nominalization. Second, the inclusion strategies consist of (1) objectiveness, (2) nomination, (3) nomination-identification, (4) determination, and (5) individualization. All those strategies are used by journalists to marginalize corruptors.
Etiology of Acute Kidney Injury in Hospitalized Patients in a Tertiary Care Hospital
Authors: Karim Md Ataul , Rahman Md Habibur , Hassan Md Habib , Zahed A S M , Uddin Md Jashim , Sarkar Shoman 
Published: June 2023

Background: Acute Kidney Injury (AKI) previously referred to as acute renal failure complicates acute care hospital admissions and intensive care unit patients. In AKI associated with sepsis and multiple organ failure, mortality is high and the outcome is usually determined bythe severity of the underlying disorder and other complications, rather than by kidney injury itself. Aim of our study was to evaluate the etiological profile of AKI in a tertiary care hospital like Chittagong Medical College Hospital (CMCH).
Materials and methods: This observational study was conducted among 100 hospitalized patients in different wards of CMCH from November 2018 to April 2019. Patients were selected based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria of AKI. An increase in serum creatinine >0.3 mg/dl or >1.5 times the baseline and a fall of urine output <0.5 ml/kg/h for 6–12 h were the criteria for selection. A structured questionnaire was completed andbaseline level of serum creatinine, urine output were documented.
Results: Out of 100 patients, 56 were males and 44 were females. Mean age of the patients was 40.89±12.74 years. Diabetes mellitus and Hypertension were the common comorbidities. Hypovolaemia and Sepsis were found to be most common cause which included diarrheal illness (27 patients) followed by Urinary Tract Infection (9 patients) and Community-Acquired Pneumonia (4 patients). Eleven patients had Surgical causes and only 8 had Obstetrical causes.
Conclusion: Causes of AKI arepreventable and treatable. Timely appropriate management will reduce the incidence and improve the outcome of AKI.
JCMCTA 2020 ; 31 (1) : 108-112
Câncer de mama: importância dos marcadores tumorais
Authors: Jacinto Stela Morais , Brum Helineide Cristina Campos 
Published: June 2023

O câncer de mama é a patologia mais comum entre as mulheres no Brasil e no mundo, responsável por altas taxas de mortalidade, e considerado como um grande problema de saúde pública. O câncer de mama apresenta diversos marcadores tumorais que podem ser encontrados em diferentes estágios do desenvolvimento do tumor desde o início até possíveis recidivas. Os biomarcadores tumorais são utilizados para o diagnóstico diferencial em pacientes sintomáticos, estadiamento clínico, estabelecimento do diagnóstico, monitoramento da eficiência terapêutica, localização de metástases, tratamento por imuno radioterapia e detecção precoce da recorrência. Portanto foi realizada uma revisão bibliográfica narrativa com o objetivo de demonstrar a importância dos biomarcadores, consultando publicações disponíveis nos principais bancos de dados como Google Acadêmico, PubMed, SciELO, também artigos publicados pela INCA. Foram selecionados 22 artigos que contribuíram para a conclusão do estudo, que apresentam a grande importância dos biomarcadores tumorais na avaliação do tumor desde que descoberto até seu reaparecimento, podendo avaliar o prognóstico, grau de estadiamento, tratamento e posteriormente para acompanhar a sua eficácia.
Efficacy and safety of Danlou tablets in traditional Chinese medicine for coronary heart disease: a systematic review and meta-analysis
Authors: Mao WeiLi , Lu Peng , Wan Renhong , Mao Kaili , Lv Yanzhu , Hu Jie , Fu Zhenling , Wang Jun 
Published: June 2023

BackgroundDanlou tablets exert auxiliary advantages in treating coronary heart disease (CHD), but a summary of evidence-based proof is lacking. This study aims to systematically evaluate Danlou tablets in treating CHD from two aspects, including efficacy and safety.MethodsBy a thorough retrieval of the four English databases, namely, PubMed, The Cochrane Library, Embase, and Web of Science, and the four Chinese databases, namely, CNKI, Wanfang, VIP database, and China Biomedical Literature Service System, we found all randomized controlled trials (RCTs) related to Danlou tablets in treating CHD. The retrieval time was from the construction of the database to April 2022. We engaged two researchers to screen the studies, extract the required data, and assess the risk of bias. We then used RevMan5.3 and STATA.14 software to conduct a meta-analysis. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of outcome indicators.ResultsSeventeen RCTs involving 1,588 patients were included. The meta-analysis results are displayed as follows: clinical treatment effect [risk ratio (RR) = 1.22, 95% confidence interval (CI): 1.16, 1.28, P &lt; 0.00001], angina pectoris duration [MD = −0.2.15, 95% CI: −2.91, −1.04, P &lt; 0.00001], angina pectoris frequency [standard mean difference (SMD) = −2.48, 95% CI: −3.42, −1.54, P &lt; 0.00001], angina pectoris degree [SMD = −0.96, 95% CI: −1.39, −0.53, P &lt; 0.0001], TC [MD = −0.71, 95% CI: −0.92, −0.51, P &lt; 0.00001], TG [MD = −0.38, 95% CI: −0.53, −0.22, P &lt; 0.00001], low-density lipoprotein cholesterol [MD = −0.64, 95% CI: −0.76, −0.51, P &lt; 0.00001], high-density lipoprotein cholesterol [MD = 0.16, 95% CI: 0.11, 0.21, P &lt; 0.00001], and adverse events [RR = 0.46, 95% CI: 0.24, 0.88, P = 0.02].ConclusionThe current evidence suggests that the combination of Danlou tablets and Western medicine can enhance the efficacy of CHD and does not increase adverse events. However, because of the limited number and quality of the included studies, the results of our study should be treated with caution. Further large-scale RCTs are necessary to verify the benefits of this approach.
Body condition and corticosterone stress response, as markers to investigate effects of human activities on Adélie penguins (Pygoscelis adeliae)
Authors: Marciau Coline , Raclot Thierry , Bestley Sophie , Barbraud Christophe , Delord Karine , Hindell Mark Andrew , Kato Akiko , Parenteau Charline , Poupart Timothée , Ribout Cécile , Ropert-Coudert Yan , Angelier Frédéric 
Published: June 2023

IntroductionIn Antarctica, there is growing concern about the potential effect of anthropogenic activities (i.e., tourism, research) on wildlife, especially since human activities are developing at an unprecedented rate. Although guidelines exist to mitigate negative impacts, fundamental data are currently lacking to reliably assess impacts. Physiological tools, such as circulating corticosterone levels, appear promising to assess the potential impact of human disturbance on Antarctic vertebrates.MethodsIn this study, we compared the body condition, and the physiological sensitivity to stress (i.e., basal and stress-induced corticosterone level) of adult and chick Adélie penguins between a disturbed and an undisturbed area (i.e., 2 colonies located in the middle of a research station exposed to intense human activities and 2 colonies located on protected islands with minimal human disturbance).ResultsWe did not find any significant impact of human activities on body condition and corticosterone levels in adults (incubating adults, brooding adults). In chicks, there were significant inter-colony variations in stress-induced corticosterone levels. Specifically, the chicks from the disturbed colonies tended to have higher stress-induced corticosterone levels than the chicks from the protected areas although this difference between areas was not significant. In addition, and independently of human disturbance we also found significant differences in adult body condition, and chick corticosterone level between colonies.DiscussionOverall, our study suggests that this species is not dramatically impacted by human activities, at least when humans and penguins have cohabited for several decades. Our results support therefore the idea that this species is likely to be tolerant to human disturbance and this corroborates with the persistence of Adélie penguin colonies in the middle of the research station. However, our results also suggest that chicks might be more sensitive to human disturbance than adults and might therefore potentially suffer from human disturbance. Our study also suggests that specific individual and environmental variables outweigh the potential minor impact of human disturbance on these variables. Combining corticosterone with complementary stress-related physiological markers, such as heart rate, may strengthen further studies examining whether human disturbance may have subtle detrimental impacts on individuals.
Vasculogenic mimicry score identifies the prognosis and immune landscape of lung adenocarcinoma
Authors: Yang Weichang , Li Zhouhua , Wang Wenjun , Wu Juan , Li Jinbo , Huang Xiaotian , Zhang Xinyi , Ye Xiaoqun 
Published: June 2023

Background: Lung cancer has a high incidence and mortality rate worldwide. Vasculogenic mimicry (VM) is a specific modality of tumor angiogenesis that could potentially be a new target for tumor therapy. The purpose of this study was to explore the role of VM-related genes in assessing the prognosis and immune landscape of lung cancer.Methods: VM-related genes were obtained from previous studies, and the expression data and clinical data of lung adenocarcinoma (LUAD) patients were obtained from the TCGA database and GEO database. We performed enrichment analysis of 24 VM-related genes and screened hub genes by constructing a protein–protein interaction network and using Cytoscape software. Subsequently, we developed the VM score based on univariate Cox regression analysis and Lasso analysis and validated the VM score on the GSE72094 dataset. In addition, we constructed a nomogram based on the VM score in the TCGA cohort. Finally, we explored the correlation between the VM score and the tumor microenvironment, immune cell infiltration, immune checkpoints, and drug sensitivity.Results: Enrichment analysis revealed that VM-related genes were associated with the HIF signaling pathway and angiogenic pathway. We developed a VM score based on 3 genes (EPHA2, LAMC2 and LOXL2) in LUAD patients. Kaplan-Meier analysis showed that the VM score was associated with poor prognosis in LUAD patients. The receiver operating characteristic curve suggested that the VM score and nomogram are valid predictors for the overall survival of LUAD patients. The VM score was significantly correlated with immune cell infiltration, such as naïve B cells, neutrophils, and eosinophils, and there was a difference in the TME between the high VM score group and the low VM score group. LUAD patients in the high VM score group were more sensitive to antitumor drugs.Conclusion: In summary, the VM score developed in this study is a valuable indicator for evaluating the prognosis and immune landscape of LUAD patients. VM may be a potential target for antitumor therapy in lung cancer.
Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state
Authors: Paladines Nathalie , Dawson Shantiece , Ryan Weston , Serrano-Lopez Rogelio , Messer Regina , Huo Yuqing , Cutler Christopher W. , Ramos-Junior Erivan S. , Morandini Ana Carolina 
Published: June 2023

IntroductionFibroblasts are the dominant stromal cells in the gingival lamina propria with a well-established relevance in regulation of inflammation, and in innate immunity. This is exemplified by their hypersecretion of CXCL8, enhancing leukocyte infiltration in chronic and sustained inflammatory conditions. We have previously shown adenosine to be a key metabolic nucleoside that regulates stromal inflammation, but the underlying mechanisms linking adenosine to the metabolic status of fibroblasts and to the resultant inflammatory response are unclear. This study examined, by seahorse real-time cell metabolic analysis, the bioenergetics of the stromal fibroblast response to extracellular adenosine and IL-1β, focusing on CXCL8 secretion by primary human gingival fibroblasts (HGF).MethodsMarkers of the glycolytic pathway and mitochondrial biogenesis were tracked through immunoblot. Further, the influence of adenosine on mitochondrial accumulation was measured by uptake of MitoTracker Red fluorescent probe and assessment of the role of FCCP (a mitochondrial uncoupler) in CXCL8 secretion and mitochondrial accumulation. ResultsOur results show that the anti-inflammatory response of HGF to extracellular adenosine, typified by reduced CXCL8 secretion, is mediated by mitochondrial oxidative phosphorylation, reflected in higher oxygen consumption rate (OCR). In the presence of IL-1β, adenosine-treated cells induced higher ATP production, basal respiration and proton leak compared to IL-1β without adenosine. Surprisingly, adenosine had no additional effect on the IL-1β-induced higher glycolysis rate demonstrated by the extracellular acidification rate (ECAR). In addition, the higher OCR in adenosine-stimulated cells was not due to the mitochondrial fuel dependency or capacity, but due to an increase in mitochondrial biogenesis and accumulation in the cells with concomitant decrease in mitophagy-required p-PINK1 marker. We detected the accumulation of functional mitochondria with increased activation of the AMPK/SIRT1/PGC-1α pathway. The adenosine-induced uptake of MitoTracker was abrogated by PGC-1α inhibition with SR-12898. In addition, the adenosine effects on reduced CXCL8 were ablated by treatment with FCCP, a potent uncoupler of mitochondrial oxidative phosphorylation.ConclusionOur findings reveal a key role for mitochondrial bioenergetics in regulation of CXCL8-mediated inflammation by HGF through the adenosine/AMPK/SIRT1/PGC-1α axis. Therapeutically targeting this pathway in gingival fibroblasts might be a promising future strategy to modulate stromal-mediated sustained hyper-inflammatory responses.
Study on the effect of mineral admixtures on working and mechanical properties of the grouting material
Authors: Shen Quanjun , Jiang Ruishuang , Cong Bori , Guo Baolin , Shang Hongfa , Ji Xiaoge 
Published: June 2023

Aiming at the existing grouting material, there are a series of problems such as poor fluidity of the grouting, rapid loss of fluidity, non-compactness of the grouting after hardening, gaps or holes, and the like. In this paper, fly ash, limestone powder, and silica fume are used to replace cement, and the influence of mineral admixtures on the fluidity, rheological properties, and strength of the grouting material are systematically studied. The experiment found that: fly ash, limestone powder, and silica fume can all improve the fluidity of the grouting material, and the effect of fly ash is the best. Compared with pure cement grouting, the initial fluidity and 60 min fluidity of the grouting material mixed with 40 wt% fly ash were reduced by 35.5% and 53.8% respectively. Fly ash and limestone powder mixed into the grouting material will significantly improve the rheological properties, while silica fume will reduce the flow properties of the grouting. The addition of fly ash and limestone powder will reduce the mechanical properties of the grouting material, while silica fume can improve the mechanical properties of the grouting material. Compared with pure cement grouting, the 28 days compressive strength with 4 wt% limestone powder grouting material is reduced by 4.5%, and the flexural strength is reduced by 6%; the 28 days compressive strength with 4 wt% silica fume grouting material is increased by 6.5%, the flexural strength increased by 1%.
Molecular crosstalk between COVID-19 and Alzheimer’s disease using microarray and RNA-seq datasets: A system biology approach
Authors: Premkumar T. , Sajitha Lulu S. 
Published: June 2023

ObjectiveCoronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The clinical and epidemiological analysis reported the association between SARS-CoV-2 and neurological diseases. Among neurological diseases, Alzheimer’s disease (AD) has developed as a crucial comorbidity of SARS-CoV-2. This study aimed to understand the common transcriptional signatures between SARS-CoV-2 and AD.Materials and methodsSystem biology approaches were used to compare the datasets of AD and COVID-19 to identify the genetic association. For this, we have integrated three human whole transcriptomic datasets for COVID-19 and five microarray datasets for AD. We have identified differentially expressed genes for all the datasets and constructed a protein–protein interaction (PPI) network. Hub genes were identified from the PPI network, and hub genes-associated regulatory molecules (transcription factors and miRNAs) were identified for further validation.ResultsA total of 9,500 differentially expressed genes (DEGs) were identified for AD and 7,000 DEGs for COVID-19. Gene ontology analysis resulted in 37 molecular functions, 79 cellular components, and 129 biological processes were found to be commonly enriched in AD and COVID-19. We identified 26 hub genes which includes AKT1, ALB, BDNF, CD4, CDH1, DLG4, EGF, EGFR, FN1, GAPDH, INS, ITGB1, ACTB, SRC, TP53, CDC42, RUNX2, HSPA8, PSMD2, GFAP, VAMP2, MAPK8, CAV1, GNB1, RBX1, and ITGA2B. Specific miRNA targets associated with Alzheimer’s disease and COVID-19 were identified through miRNA target prediction. In addition, we found hub genes-transcription factor and hub genes-drugs interaction. We also performed pathway analysis for the hub genes and found that several cell signaling pathways are enriched, such as PI3K-AKT, Neurotrophin, Rap1, Ras, and JAK–STAT.ConclusionOur results suggest that the identified hub genes could be diagnostic biomarkers and potential therapeutic drug targets for COVID-19 patients with AD comorbidity.
Differences in the composition of the bacterial element of the urinary tract microbiome in patients undergoing dialysis and patients after kidney transplantation
Authors: Jaworska Marcelina M. , Pecyna Paulina , Jaskiewicz Katarzyna , Rydzanicz Małgorzata , Kaluzna Malgorzata , Pawlaczyk Krzysztof , Ploski Rafal , Nowak-Malczewska Dorota M. , Karolak Justyna A. , Gajecka Marzena 
Published: June 2023

IntroductionThe development of molecular biology methods and their application in microbial research allowed the detection of many new pathogens that cause urinary tract infections (UTIs). Despite the advances of using new research techniques, the etiopathogenesis of UTIs, especially in patients undergoing dialysis and patients after kidney transplantation, is still not fully understood.MethodsThis study aimed to characterize and compare the composition of the bacterial element of the urinary tract microbiome between the groups of patients undergoing dialysis (n = 50) and patients after kidney transplantation (n = 50), with positive or negative urine culture, compared to healthy individuals (n = 50).ResultsAsymptomatic bacteriuria was observed in 30% of the urine cultures of patients undergoing dialysis and patients after kidney transplantation, with Escherichia coli as the most dominant microorganism (73%) detected with the use of classical microbiology techniques. However, differences in the bacterial composition of the urine samples between the evaluated patient groups were demonstrated using the amplicon sequencing. Finegoldia, Leptotrichia, and Corynebacterium were found to be discriminative bacteria genera in patients after dialysis and kidney transplantation compared to the control group. In addition, in all of urine samples, including those without bacteriuria in classical urine culture, many types of bacteria have been identified using 16S rRNA sequencing.DiscussionThe revealed microbial characteristics may form the basis in searching for new diagnostic markers in treatment of patients undergoing dialysis and patients after kidney transplantation.