bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of artificial blood loss and duration of excision score to evaluate surgical difficulty of total laparoscopic anterior resection in rectal cancer
Authors: Lv Jingfang , Guan Xu , Wei Ran , Yin Yefeng , Liu Enrui , Zhao Zhixun , Chen Haipeng , Liu Zheng , Jiang Zheng , Wang Xishan 
Published: March 2023

PurposeTotal laparoscopic anterior resection (tLAR) has been gradually applied in the treatment of rectal cancer (RC). This study aims to develop a scoring system to predict the surgical difficulty of tLAR.MethodsRC patients treated with tLAR were collected. The blood loss and duration of excision (BLADE) scoring system was built to assess the surgical difficulty by using restricted cubic spline regression. Multivariate logistic regression was used to evaluate the effect of the BLADE score on postoperative complications. The random forest (RF) algorithm was used to establish a preoperative predictive model for the BLADE score.ResultsA total of 1,994 RC patients were randomly selected for the training set and the test set, and 325 RC patients were identified as the external validation set. The BLADE score, which was built based on the thresholds of blood loss (60 ml) and duration of surgical excision (165 min), was the most important risk factor for postoperative complications. The areas under the curve of the predictive RF model were 0.786 in the training set, 0.640 in the test set, and 0.665 in the external validation set.ConclusionThis preoperative predictive model for the BLADE score presents clinical feasibility and reliability in identifying the candidates to receive tLAR and in making surgical plans for RC patients.
Correlation of tumor mutational burden with prognosis and immune infiltration in lung adenocarcinoma
Authors: Li Lin , Li Junyu 
Published: March 2023

BackgroundTumor mutational burden (TMB) plays an important role in the evaluation of immunotherapy efficacy in lung adenocarcinoma (LUAD).ObjectiveTo improve the clinical management of LUAD by investigating the prognostic value of TMB and the relationship between TMB and immune infiltration.MethodsTMB scores were calculated from the mutation data of 587 LUAD samples from The Cancer Genome Atlas (TCGA), and patients were divided into low-TMB and high-TMB groups based on the quartiles of the TMB score. Differentially expressed genes (DEGs), immune cell infiltration and survival analysis were compared between the low-TMB and high-TMB groups. We queried the expression of genes in lung cancer tissues through the GEPIA online database and performed experimental validation of the function of aberrant genes expressed in lung cancer tissues.ResultsWe obtained sample information from TCGA for 587 LUAD patients, and the results of survival analysis for the high- and low- TMB groups suggested that patients in the high-TMB group had lower survival rates than those in the low-TMB group. A total of 756 DEGs were identified in the study, and gene set enrichment analysis (GSEA) showed that DEGs in the low-TMB group were enriched in immune-related pathways. Among the differentially expressed genes obtained, 15 immune-related key genes were screened with the help of ImmPort database, including 5 prognosis-related genes (CD274, PDCD1, CTLA4, LAG3, TIGIT). No difference in the expression of PDCD1, CTLA4, LAG3, TIGIT in lung cancer tissues and differential expression of CD274 in lung cancer tissues.ConclusionsThe survival rate of LUAD patients with low TMB was better than that of LUAD patients with high TMB. CD274 expression was down regulated in human LUAD cell lines H1299, PC-9, A549 and SPC-A1, which inhibited malignant progression of A549 cells.
The diagnostic performance of 18F-DCFPyL PET in patients with suspected prostate cancer: A systemic review and meta-analysis
Authors: Pang Wenyang , Cheng Shulin , Du Zhongbo , Du Shuang 
Published: March 2023

IntroductionOur meta-analysis aimed to evaluate the diagnostic value of 18F-DCFPyL prostate-specific membrane antigen (PSMA) PET in patients with suspected prostate cancer.MethodsWe searched for articles that evaluate the diagnostic value of 18F-DCFPyL PSMA PET in patients with suspected prostate cancer in PubMed, Embase, Cochrane Library, and Web of Science until 1 August 2022. Using the QUADAS-2 instrument, two researchers independently assessed the effectiveness of the studies that were included. The four-grid table data were analyzed by Meta-disc1.4 and Stata 16.0 software. The heterogeneity of each study was tested.ResultsA total of five studies with 258 patients were included, and the pooled sensitivity and specificity of 18F-DCFPyL PSMA PET for primary prostate cancer were 0.92 (95% confidence interval (CI): 0.85–0.96) and 0.59 (95% CI: 0.08–0.96), respectively. 18F-DCFPyL PSMA PET was successful in detecting primary prostate cancer, with an area under the curve (AUC) of 0.92 (95% CI: 0.89–0.94).Conclusions18F-DCFPyL PSMA PET has a strong predictive value for primary prostate cancer and is an effective method for the non-invasive diagnosis of prostate cancer. More prospective articles were needed.
Effects of sodium tanshinone IIA sulfonate injection on inflammatory factors and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A systematic review and meta-analysis of randomized clinical trials
Authors: Kan Zunqi , Yan Wenli , Yang Mengqi , Gao Huanyu , Meng Dan , Wang Ning , Fang Yuqing , Wu Lingyu , Song Yongmei 
Published: March 2023

Background: Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) therapy may experience further damage to the vascular endothelium, leading to increased inflammatory response and in-stent thrombosis. In many clinical studies, sodium tanshinone IIA sulfonate injection (STS) has been found to reduce inflammatory factors and enhance vascular endothelial function in patients with ACS while improving the prognosis of PCI. However, to date, there has been no systematic review assessing the effectiveness and safety of STS on inflammatory factors and vascular endothelial function.Purpose: The aim of this study is to systematically review the effects of STS on inflammatory factors and endothelial function in patients with ACS treated with PCI.Methods: Until October 2022, eight literature databases and two clinical trial registries were searched for randomized controlled trials (RCTs) investigating STS treatment for ACS patients undergoing PCI. The quality of the included studies was assessed using the Cochrane Risk Assessment Tool 2.0. Meta-analysis was performed using RevMan 5.4 software.Results: Seventeen trials met the eligibility criteria, including 1,802 ACS patients undergoing PCI. The meta-analysis showed that STS significantly reduced high-sensitivity C-reactive protein (hs-CRP) levels (mean difference [MD = −2.35, 95% CI (−3.84, −0.86), p = 0.002], tumor necrosis factor-alpha (TNF-α) levels (standard mean difference [SMD = −3.29, 95%CI (−5.15, −1.42), p = 0,006], matrix metalloproteinase-9 (MMP-9) levels [MD = −16.24, 95%CI (−17.24, −15.24), p &lt; 0.00001], and lipid peroxidation (LPO) levels [MD = −2.32, 95%CI (−2.70, −1.93), p &lt; 0.00001], and increased superoxide dismutase (SOD) levels [SMD = 1.46, 95%CI (0.43, 2.49), p = 0,006] in patients with ACS. In addition, STS significantly decreased the incidence of major adverse cardiovascular events (relative risk = 0.54, 95%CI [0.44, 0.66], p &lt; 0.00001). The quality of evidence for the outcomes was assessed to be very low to medium.Conclusion: STS can safely and effectively reduce the levels of hs-CRP, TNF-α, MMP-9, and LPO and increase the level of SOD in patients with ACS treated with PCI. It can also reduce the incidence of adverse cardiovascular events. However, these findings require careful consideration due to the small number of included studies, high risk of bias, and low to moderate evidence. In the future, more large-scale and high-quality RCTs will be needed as evidence in clinical practice.
Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq
Authors: Luo Yue-Ming , Yang Shu-Dong , Wen Miao-Yu , Wang Bing , Liu Jia-Hui , Li Si-Ting , Li Yu-Yan , Cheng Hong , Zhao Li-Li , Li Shun-Min , Jiang Jian-Jun 
Published: March 2023

IntroductionTriptolide (TPL) is a promising plant-derived compound for clinical therapy of multiple human diseases; however, its application was limited considering its toxicity.MethodsTo explore the underlying molecular mechanism of TPL nephrotoxicity, a network pharmacology based approach was utilized to predict candidate targets related with TPL toxicity, followed by deep RNA-seq analysis to characterize the features of three transcriptional elements include protein coding genes (PCGs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) as well as their associations with nephrotoxicity in rats with TPL treatment.Results &amp; DiscussionAlthough the deeper mechanisms of TPL nephrotoxcity remain further exploration, our results suggested that c-Jun is a potential target of TPL and Per1 related circadian rhythm signaling is involved in TPL induced renal toxicity.
Identification factors to adjust early combination regimens in adult primary immune thrombocytopenia: An 8-year data analysis
Authors: Iam-arunthai Kunapa , Chamnanchanunt Supat , Thungthong Pravinwan , Nakhahes Chajchawan , Suwanban Tawatchai , Rojnuckarin Ponlapat 
Published: March 2023

PurposeRecent studies suggested that adding other agents to corticosteroids as a first-line treatment for immune thrombocytopenia (ITP) could improve outcomes. However, combination regimens may increase side effects and costs. To determine clinical factors associated with responses to the first-line steroid at 1 month.Materials and methodsWe retrospectively reviewed the medical records of patients with ITP aged ≥ 18 years, who were treated at Rajavithi Hospital between 2012 and 2020. Clinical data, laboratory results, treatment regimens, and responses to therapy were analyzed.ResultsOf the 226 patients, 76.6% were female. The mean age was 46.5 ± 18.1 years, and the median follow-up duration was 40 months. The proportion of chronic ITP was 97.3%. The complete response and response rates to first-line therapy were 65.5% and 88.9%, respectively. The age over 26 years, presentation clinically non-significant bleeding and a difference in platelet count of &gt;50 x 109/L between days 1 and 7 after initial treatment were associated with the response to first-line treatment (adjusted odds ratio [OR] 5.09, 95% confidence interval [CI] 1.50-17.28, p = 0.009); OR 5.87, 95%CI 1.19-28.91, p = 0.029, and OR 3.60, 95%CI 1.10-11.73, p = 0.034, respectively. Younger patients and a difference in platelet count between day 1 and 7 ≤ 50 x 109/L were more likely to require second-line treatments. There were significant increases in the median platelet counts after prescribing azathioprine (baseline vs. 3 months, p = 0.001), cyclophosphamide (baseline vs. 6 months, p = 0.021), or danazol (baseline vs. 12 months, p = 0.039).ConclusionAdult, severity of bleeding at presentation, and rapid platelet increases within 1 week were related to excellent corticosteroid responses in ITP patients. These patients may not need combination regimens.
SISTEM TEMU KEMBALI INFORMASI IMAGE BERDASARKAN ANNOTATION PICTURE MENGGUNAKAN COSINE SIMILARITY
Authors: Februariyanti Herny , Diartono Dwi Agus , Ningsih Dewi Handayani Untari 
Published: March 2023

Pencarian gambar banyak sekali caranya salah satunya berdasarkan anotasi atau keterangan dari gambar. Kata kunci yang dimasukkan ke dalam sistem sebagai acuan dalam pencarian kemudian dibandingkan dengan anotasi dari gambar. Sistem yang dibangun untuk proses pencarian gambar ini menggunakan tahapan sistem temu kembali informasi. Metode yang diterapkan pada sistem temu kembali informasi ini menggunakan algoritma kemiripan cosine similarity. Metode cosine similarity ini digunakan untuk membandingkan kata kunci yang dimasukkan sebagai kata pencarian dibandingkan dengan anotasi dari gambar yang sebelumnya telah melalui beberapa tahapan dan yang terakhir proses stopword. Hasil perbandingan kemiripan kata kunci dan anotasi akan menghasilkan nilai antara 0 sampai dengan 1. Apabila nilai mendekati angka 1 maka antara kata kunci dengan anotasi dikatakan semakin mirip. Sebaliknya semakin mendekati angka 0 dikatakan semakin tidak mirip. Sehingga dari hasil proses penggunaan algoritma kemiripan cosine similarity akan didapatkan daftar urutan gambar beserta anotasinya dari nilai 1 hingga yang paling kecil 0. Dan gambar akan ditampilkan secara berurutan berdasarkan urutan nilai tersebut. Artinya gambar yang ditampilkan paling atas berarti semakin sesuai dengan yang dicari oleh pengguna. Hasil dari pencarian gambar dari data yang sebelumnya mempunyai urutan 1,2,3,4,5, setelah dilakukan pencarian berdasarkan kemiripan anotasi gambar urutan hasil pencarian menjadi 4,3,5,21.
PENCARIAN POLA TRANSAKSI FO HILON TANGERANG MENGGUNAKAN METODE ASOSIASI FP-GROWTH
Authors: Hardya Hafizhannia Rahma , Jananto Arief 
Published: March 2023

Abstrak
FO Hilon adalah menjual barang berupa furniture rumah dengan bahan baku berpacu pada darcon, akan lebih baik bila dilakukan analisis pada toko tersebut. Penelitian ini dilakukan karena adanya data transaksi penjualan yang terus menumpuk untuk setiap tahunnya. Sehingga perlu untuk dilakukannya analisis pada data tersebut agar tidak disimpan secara percuma. Untuk melihat pengaruh data tersebut maka perlu dilakukan teknik data mining yang mana menggunakan metode asosiasi dengan algoritma yang dipakai yaitu FP-Growth dari situ akan terbentuk sebuah pola transaksi konsumen.
Hasil penelitian menunjukan bahwa terdapat 2 percobaan yaitu perhitungan manual dengan sample data 100 transaksi menggunakan dua parameter nilai minsup=0,04 dan minimum confidence 0,2 menghasilnya 8 rules pola asosiasi yang memenuhi syarat. Uji coba yang kedua yaitu dengan menggunakan RStudio terdapat 1.804 transaksi dengan parameter nilai minsup=0,01 dan minimum confidence 0,2 dengan consequent frequent item DP 45X65 menghasilkan 14 rules.
Kata Kunci : Data Mining Asosiasi, Algoritma FP-Growth, Pola Transaksi
EVALUASI KINERJA ASET SIMDAS BERDASARKAN IISS (INTEGRATED INFORMATION SYSTEMS SUCCESS) DI BPDAS CITARUM-CILIWUNG
Authors: Warlan Adelia Chrismayanti , Priyatiningsih Katharina , Ramadhan Gilang 
Published: March 2023

BPDAS Citarum-Ciliwung adalah salah satu instansi pemerintahan dibawah Kementrian Lingkungan Hidup dan Kehutanan yang memiliki tugas pokok dan fungsi menyajikan informasi mengenai perencanaan pengelolaan DAS, pengembangan kelembagaan dan kemitraan pengelolaan DAS maupun pemantauan dan evaluasi pengelolaan DAS. Kegiatan pengelolaan DAS dilakukan melalui aplikasi SIMDAS yang dikelola oleh Seksi Evaluasi Pengelolaan DAS. Objek dalam artikel ini adalah kinerja SIMDAS terhadap kegiatan pengelolaan aset DAS di BPDAS Citarum-Ciliwung. Pada proses pengelolaan DAS terdapat permasalahan dalam penggunaan sistem yang diterapkan. SIMDAS belum terintegrasi dan masih berbasis offline sehingga tingkat fleksibilitas dan efisiensinya cukup rendah, informasi yang tersaji belum cepat dan akurat, penggunaan aplikasi sulit dimengerti oleh orang awam, dan keterbatasan pengguna dalam mengakses aplikasi, sehingga diperlukan evaluasi pada kinerja SIMDAS tersebut menggunakan Integrated Information Systems Success. Tujuan dari studi kasus ini adalah mengidentifikasi masalah kinerja SIMDAS terhadap pengelolaan aset DAS kemudian mengajukan rekomendasi rancangan alternatif solusi untuk mengatasi masalah kinerja aset SIMDAS tersebut. Metode yang digunakan dalam penelitian ini yakni metode penelitian deskriptif khususnya deskriptif ekspalatori dengan menggunakan pendekatan kualitatif dan kuantitatif. Teknik pengumpulan data yang digunakan dalam penelitian studi kasus ini yakni wawancara, observasi ilmiah, kuesioner, dan studi dokumentasi. Hasil dari studi kasus ini adalah rekomendasi perancangan SIMDAS di BPDAS Citarum-Ciliwung.
PERANCANGAN SISTEM INFORMASI SERCATEN UNTUK PEMBUATAN SERTIFIKAT LAYAK NIKAH DI PUSKESMAS TELUK PUCUNG
Authors: Salsabila Nadia , Fauzi Ahmad 
Published: March 2023

Puskesmas merupakan salah satu fasilitas kesehatan yang sudah memanfaatkan kemajuan teknologi yang ada saat ini di bidang kesehatan. Kemajuan teknologi yang membawa manfaat sangat beragam untuk bidang kesehatan ini salah satunya digunakan pada rangkaian administrasi untuk mendaftar di puskesmas. Diantara seluruh kategori yang terdapat pada pelayanan rawat jalan, Caten merupakan kategori yang menghabiskan waktu cukup banyak. Selain itu, pengunjung dengan kategori Caten lupa membawa berkas dan datang terlalu siang, membuat mereka menunda pembuatan sertifikatnya. Sebagai wujud pemanfaatan teknologi yang ada, maka perlu adanya suatu sistem informasi yang dapat melengkapi kekurangan tersebut agar proses yang dilalui calon pengantin lebih mudah selain itu dapat mempermudah petugas puskesmas dalam mengarsipkan data para calon pengantin. Setelah melakukan wawancara, observasi, dan kajian literasi, maka terciptalah beberapa ide yang menjadi dasar dalam membuat perancangan sistem informasi sercaten (Sertifikat Calon Pengantin). Perancangan aplikasi berbasis web ini dapat menyimpan berkas-berkas registrasi, memuat informasi seputar pemeriksaan kesehatan apa saja yang akan dilalui, pukul berapa saja para calon pengantin dianjurkan datang, dan beberapa manfaat lainnya yang dapat membantu para calon pengantin.
Digitalization in health care: Promising tools
Authors: Doan T. M. , Krest'yaninova O. G. , Plotnikov V. A. 
Published: March 2023

Aim. The presented study aims to consider the possibilities and features of the development of digitalization in health care under modern conditions (through the example of Russia).Tasks. The authors describe the essence and trends of digitalization and the industry-specific features of its manifestation in health care; analyze the available digital technologies from the perspective of their use in health care; identify directions for the development of RWD and RWE systems in Russia and assess the need for a transformation of the institutional environment of health care in the context of their introduction.Methods. This study uses general scientific research methods (analysis, synthesis, monographic method, grouping), as well as methods of institutional and sectoral techno-economic analysis.Results. The process of digital transformation in the health care sector is analyzed, and the introduction of RWD and RWE systems and artificial intelligence systems is examined in detail. In the context of a study of development trends in digital health care, recommendations for improving the collection, processing, and storage of medical information are given. New means of working with medical data and directions for the development of digital medical services and medical care using digital technologies are described.Conclusions. Digitalization in health care is aimed at improving the efficiency and effectiveness of medical care and medical services through the application of innovative approaches and the expanded use of digital tools. Global experience shows that patients and medical organizations can successfully use personalized solutions in the field of digital health care to improve disease prevention, self-care, and access to health care, providing that they are designed with allowance for the needs and preferences of the patient. However, these issues require improved processes not only at the level of organizations, but also at the level of industrial regulatory bodies.
Gamiﬁcation in human resource management through the example of Russian and foreign companies
Authors: Denisov A. F. , Skornyakov M. A. 
Published: March 2023

Aim. The presented study aims to assess the applicability of gamification methods used in human resource management processes to draw a conclusion about the feasibility of implementing such principles in the strategies of Russian and foreign companies.Tasks. The authors review the cultural aspects of the phenomenon of gamification and substantiate its essence; describe the methods and tools used in this field; analyze the examples of gamification in business, particularly in the field of human resource management.Methods. This study analyzes literary sources, articles from electronic journals, and scientific research of companies in the field of personnel management.Results. A study of the application of gamification in human resource management shows the prospects of this direction, its advantages and disadvantages.Conclusions. The use of gamification makes even routine tasks less monotonous, and employees become more involved from the early stages of their work for the company. High motivation to work, feedback, and the development of social ties lead to increased job satisfaction and, as a result, to greater productivity, fewer mistakes, less absenteeism and employee turnover. Gamification can contribute to creating a positive image of an organization, spreading the values it represents, its missions and visions among the “players”.
Mechanism for assessing the effects of strategic partnership for the sustainable digital development of transport structures and transportation companies
Authors: Kosheleva T. N. 
Published: March 2023

Aim. The presented study aims to develop methodological approaches to assessing the effects of strategic partnership for the sustainable digital development of transport structures and transportation enterprises.Tasks. The author defines approaches to the sustainable development of entrepreneurial structures, namely: determines the features of the used model of sustainable industrial development and formulates the principles of ensuring sustainability in accordance with the nature of the inter-entrepreneurial infrastructural digital interaction of transport structures and transportation enterprises.Methods. This study uses general scientific methods of cognition in various aspects to investigate approaches to assessing the effects of strategic partnership, identify shortcomings, and propose methodological approaches to managing the formation of a mechanism for assessing the effects of strategic partnership for sustainable digital development of transport structures and transportation enterprises.Results. The author proposes using the principles of management of the formation of a mechanism for assessing the effects of strategic partnership, including the principle of consistent hierarchical ordering of management actions, the principle of resource sufficiency for management actions, and the principle of digital technological accessibility of management actions. The author considers the factors of comprehensive stability (external and internal collective stability), contributing to the identification of resource redundancy and demand, as the main factors determining the vector of management actions within the framework of the mechanism for assessing the effects of strategic partnership within the structure of the synergetic matrix of inter-entrepreneurial interaction.Conclusions. The author proposes to build the process of managing the formation of a mechanism for assessing the effects of strategic partnership for sustainable digital development of transport structures and transportation enterprises around the principles of sustainability, in accordance with the parameters of sustainable digital development and with allowance for the elements of the mechanism for assessing the effects of strategic partnership in ensuring sustainable digital development in the form of strategic partnership.