bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are the original SARS‐CoV‐2 novel mutants from in vitro culture able to escape the immune response?
Authors: He Jun , Mei Qingmin , Peng Yousong , Xie Jiajia , Li Weiwei , Ding Chengchao , Jiang Chengcheng , Chen Qingqing , Wang Jing , Zhang Yuqing , Ni Shuangshuang , Yu Junling , Liu Tao , Yang Weifei , Gong Lei , Zhang Xiangyu , Yuan Yuan , Zhang Zhuhui , He Lan , He Hongliang , Sun Yong , Wu Jiabing , Liu Zhirong , Gao Yong 
Published: July 2023

AbstractMonitoring variations in the virus genome to understand the SARS‐CoV‐2 evolution and spread of the virus is extremely important. Seven early SARS‐CoV‐2 isolates in China were cultured in vitro and were analyzed for their viral infectivity through viral growth assay, tissue culture infectious dose (TCID50) assay, spike protein quantification, and next generation sequencing analysis, and the resultant mutations in spike protein were used to generate the corresponding pseudoviruses for analysis of immune escape from vaccination and postinfection immunity. The results revealed that in vitro cultured SARS‐CoV‐2 virus had much higher mutation frequency (up to ~20 times) than that in infected patients, suggesting that SARS‐CoV‐2 diversify under favorable conditions. Monitoring viral mutations is not only helpful for better understanding of virus evolution and virulence change, but also the key to prevent virus transmission and disease progression. Compared with the D614G reference strain, a pseudovirus strain of SARS‐CoV‐2 was constructed with a high mutation rate site on the spike protein. We found some novel spike mutations during in vitro culture, such as E868Q, conferred further immune escape ability.
Supersymmetric Reshaping and Higher‐Dimensional Rearrangement of Photonic Lattices
Authors: Wolterink Tom A. W. , Heinrich Matthias , Szameit Alexander 
Published: July 2023

AbstractIntegrated Jx photonic lattices, inspired by the quantum harmonic oscillator and due to their equidistant eigenvalue spectrum, have proven extremely useful for various applications, such as perfect imaging and coherent transfer of quantum states. However, to date their large‐scale implementation remains challenging. This study applies concepts from supersymmetry (SUSY) to construct two‐dimensional (2D) systems with spectra identical to that of one‐dimensional (1D) Jx lattices. While exhibiting different dynamics, these 2D equivalent systems retain the key imaging and state transfer properties of their 1D Jx counterpart. The method extends to all systems with separable spectra and facilitates experimental fabrication of large‐scale photonic circuits.
A probabilistic thermal dose model for the estimation of necrosis in MR‐guided tumor ablations
Authors: Schröer Simon , Alpers Julian , Gutberlet Marcel , Brüsch Inga , Rumpel Regina , Wacker Frank , Hensen Bennet , Hansen Christian 
Published: July 2023

AbstractBackgroundMonitoring minimally invasive thermo ablation procedures using magnetic resonance (MR) thermometry allows therapy of tumors even close to critical anatomical structures. Unfortunately, intraoperative monitoring remains challenging due to the necessary accuracy and real‐time capability. One reason for this is the statistical error introduced by MR measurement, which causes the prediction of ablation zones to become inaccurate.PurposeIn this work, we derive a probabilistic model for the prediction of ablation zones during thermal ablation procedures based on the thermal damage model CEM43. By integrating the statistical error caused by MR measurement into the conventional prediction, we hope to reduce the amount of falsely classified voxels.MethodsThe probabilistic CEM43 model is empirically evaluated using a polyacrilamide gel phantom and three in‐vivo pig livers.ResultsThe results show a higher accuracy in three out of four data sets, with a relative difference in Sørensen–Dice coefficient from to 3.97% compared to the conventional model. Furthermore, the ablation zones predicted by the probabilistic model show a false positive rate with a relative decrease of 11.89%–30.04% compared to the conventional model.ConclusionThe presented probabilistic thermal dose model might help to prevent false classification of voxels within ablation zones. This could potentially result in an increased success rate for MR‐guided thermal ablation procedures. Future work may address additional error sources and a follow‐up study in a more realistic clinical context.
Olfactory Dysfunction in Children: A Scoping Review
Authors: Payandeh Jennifer Eva , Motamed Mehras , Kirubalingam Keshinisuthan , Chadha Neil K. 
Published: July 2023

AbstractObjectiveOlfactory disorders are well‐studied in the adult population, however, there is a paucity of literature characterizing olfactory dysfunction in pediatric patients. The purpose of this scoping review was to identify known causes of olfactory loss in pediatric populations, clarify the extent of use and validity of smell tests, and summarize current therapies for olfactory loss.Data SourcesPubMed, Ovid MEDLINE, and Web of Science.Review MethodsDatabases were systematically searched in September 2020. Two independent reviewers conducted the title and abstract screen, followed by review of full‐texts for inclusion based on preset inclusion and exclusion criteria. Extracted data included study type, age/age‐range of participants, gender, radiological evidence of olfactory dysfunction, types and results of smell tests used, etiology of olfactory loss, and therapies employed for olfactory loss.ResultsA total of 103 articles (n = 1654) were eligible for final data extraction. The University of Pennsylvania Smell Identification Test was used most frequently for smell testing (21% of studies). In total, 45 causes of olfactory dysfunction have been elucidated by this study: 22 congenital and 23 acquired. Few therapies were described, and all were specific to the etiology of olfactory loss.ConclusionOlfactory dysfunction has a wide range of etiologies in the pediatric population, and clinicians should have a diagnostic algorithm for how to identify a cause should they encounter it in practice. If no etiology can be identified, education around safety should be provided to both the patient and their caregivers.
Dr Byron J. Bailey: The Life and Legacy of an Educator, Humanitarian, and Leader
Authors: Rossi Nicholas A. , George Sachin S. , Pine Harold S. 
Published: July 2023

AbstractDr Byron J. Bailey, a preeminent figure in the field of Otolaryngology, exemplified an unwavering commitment to patient care, resident education, research excellence, and humanitarian endeavors throughout his illustrious career. Born in 1934, Dr Bailey played a pivotal role in the growth and success of the Department of Otolaryngology at the University of Texas Medical Branch. A dedicated educator and researcher, he authored groundbreaking research and the seminal textbook, Bailey's Head and Neck Surgery—Otolaryngology. His leadership in major organizations and commitment to research integrity and quality are hallmarks of his career. Dr Bailey's philanthropic pursuits include improving Otolaryngology care and access in Vietnam and Cuba, and local community efforts in Galveston, Texas. His enduring legacy continues to inspire future generations of Otolaryngologists, serving as a testament to the power of perseverance and dedication to excellence in the pursuit of medical education.
Comparative analysis of photovoltaic configurations for agrivoltaic systems in Europe
Authors: Ali Khan Niazi Kamran , Victoria Marta 
Published: July 2023

AbstractAgrivoltaics is the dual use of land by combining agricultural crop production and photovoltaic (PV) systems. In this work, we have analyzed three different agrivoltaic configurations: static with optimal tilt, vertically mounted bifacial, and single‐axis horizontal tracking. A model is developed to calculate the shadowing losses on the PV panels along with the reduced solar irradiation reaching the area under them for different PV capacity densities. First, we investigate the trade‐offs using a location in Denmark as a case study and second, we extrapolate the analysis to the rest of Europe. We find that the vertical and single‐axis tracking produce more uniform irradiance on the ground, and a capacity density of around 30 W/m2 is suitable for agrivoltaic systems. Based on our model and a 100‐m‐resolution land cover database, we calculate the potential for agrivoltaic in every region within the European Union. The potential for agrivoltaic is enormous as the electricity generated by agrivoltaic systems could produce 25 times the current electricity demand in Europe. Overall, the potential capacity for agrivoltaic in Europe is 51 TW, which would result in an electricity yield of 71,500 TWh/year.
Multilevel analysis identifying the factors associated with RSV detection in infants admitted for viral bronchiolitis in the era of the COVID‐19 pandemic
Authors: Villamil‐Osorio Milena , Moyano‐Ariza Luisa F. , Camacho‐Moreno Germán , Restrepo‐Gualteros Sonia M. , Sossa‐Briceño Monica P. , Rodriguez‐Martinez Carlos E. 
Published: July 2023

AbstractObjectivesTo identify factors independently associated with respiratory syncytial virus (RSV) detection in infants admitted for viral bronchiolitis during 3 consecutive years, before and during the COVID‐19 pandemic, in Bogota, Colombia, a middle‐income country with a subtropical highland climate.MethodsAn analytical cross‐sectional study was conducted before and during the COVID‐19 pandemic, including patients with a diagnosis of viral bronchiolitis admitted to all the hospitals of the city between January 2019 and November 2021. We evaluated a set of a priori‐selected predictor variables that included individual, healthcare system, meteorological, air pollutant, and COVID‐19 variables. Since the variables analyzed are hierarchical in nature, multilevel modeling was used to identify factors independently associated with detection of RSV as the causative agent of viral bronchiolitis.ResultsA total of 13,177 patients were included in the study. After controlling for potential confounders, it was found that age (odds ratio [OR] 0.86; 95% confidence interval [CI] 0.76–0.97), a third level of medical care institution (OR 3.05; 95% CI 1.61–5.76), temperature (OR 1.60; 95% CI 1.24–2.07), rainfall (OR 1.003, 95% CI 1.001, 1.005), NO2 (OR 0.97; 95% CI 0.95–0.99), CO (OR 0.99; 95% CI 0.99–0.99), and COVID‐19 pandemic period (OR 0.84, 95% CI 0.71–0.99) were independently associated with RSV detection in our sample of patients.ConclusionsThe identified factors associated with RSV detection provide additional scientific evidence that may be useful in the development of specific interventions aimed at ameliorating or preventing the impact of RSV in Bogota and probably other similar low‐ to middle‐income countries in high‐risk infants.
Treatment response to pulmonary exacerbation in primary ciliary dyskinesia
Authors: Gatt Dvir , Shaw Michelle , Waters Valerie , Kritzinger Fiona , Solomon Melinda , Dell Sharon , Ratjen Felix 
Published: July 2023

AbstractIntroductionPulmonary exacerbation (Pex) are common in pediatric primary ciliary dyskinesia (PCD), however changes in forced expiratory volume in 1 s precent predicted (FEV1pp) during Pex are not well described.AimTo assess the evolution of FEV1pp during Pex and to define factors associated with failure to return to baseline lung function.MethodThis was a retrospective study of patients with PCD between 2010 and 2022. Pex were defined as the presence of increased respiratory symptoms treated with intravenous (IV) antibiotics. The main outcomes were the changes in FEV1 during therapy and the proportion of patients (responders) achieving ≥90% of baseline FEV1pp values at the end of admission.ResultsThe study included 52 Pex events in 28 children with PCD. The rate of responders was 32/41 (78%) at the end of admission. Nonresponse was associated with lower median body mass index (BMI) Z‐score (−2.4 vs. −0.4, p < .01) and with a history of IV treated Pex in the previous year (p = .06). For the 22 Pex with available FEV1pp measurements at mid admission, the median relative and absolute improvement from admission to Day 7 was 9.1% and 6.2%, respectively (p‐ .001), and from Days 7 to 14 was 4.4% and 2.8%, respectively (p = .08).ConclusionIn children with PCD treated with IV antibiotics, the majority of lung function recovery happens during the first week of IV therapy. Lower BMI was associated with nonresponse to therapy.
Actinomycins produced by endophyte Streptomyces sp. GLL‐9 from navel orange plant exhibit high antimicrobial effect against Xanthomonas citri susp. citri and Penicillium italicum
Authors: Gao Liangliang , Kumaravel Kaliaperumal , Xiong Qin , Liang Yan , Ju Zhiran , Jiang Yueming , Zhang Jun 
Published: July 2023

AbstractBACKGROUNDCitrus canker and citrus blue mold are two severe diseases in citrus plants, which are mainly caused by Xanthomonas citri susp. citri (Xcc) and Penicillium italicum, respectively. The currently widely used pesticides for these two diseases are harmful to human health and the environment. Therefore, searching for novel antimicrobial agents, especially from natural resources, is getting increasing interest.RESULTSIn this study, the crude extract of Streptomyces sp. GLL‐9, an endophyte from a navel orange tree, was found to exhibit excellent antimicrobial effects against Xcc and P. italicum. Bioassay‐guided isolation led to the discovery of three actinomycins (Acts), actinomycin X2 (Act‐X2), actinomycin D (ActD), and actinomycin XOβ (Act‐XOβ). The MIC (minimum inhibitory concentration) values of Act‐X2, ActD, and Act‐XOβ were 31.25, 62.50, and 62.50 μg mL−1 against Xcc, respectively, while 62.50 (Act‐X2) and 125.00 μg mL−1 (ActD) against P. italicum, being better or comparable to the positive controls. The highest yield of Acts was obtained by solid‐state fermentation with rice containing 1% L‐tryptophan as a culture medium, being 6.03, 3.07, and 1.02 mg g−1, for Act‐X2, ActD, and Act‐XOβ, respectively. The ethyl acetate extract of Streptomyces sp. GLL‐9 cultivated under the optimal fermentation conditions (EAE‐1) can efficiently control these two citrus diseases by excessively producing reactive oxygen species (ROS) in both pathogens, damaging the cell membranes of P. italicum, and inhibiting the growth of Xcc. In addition, Act‐X2, ActD, and EAE‐1 displayed broad‐spectrum antifungal activity.CONCLUSIONEAE‐1 and Acts produced by Streptomyces sp. GLL‐9 have high potential as novel antimicrobial agents against plant pathogens. © 2023 Society of Chemical Industry.
Plant phylogeny determines host selection and acceptance of the oligophagous leaf beetle Cassida rubiginosa
Authors: Hettiarachchi Dilani K. , Rostás Michael , Sullivan Jon J. , Jackman Sarah , van Koten Chikako , Cripps Michael G. 
Published: July 2023

AbstractBACKGROUNDPredicting the host range of biocontrol agents is important for the safe and effective implementation of biocontrol of weeds. In this study, we examined the phylogenetic pattern of host selection and acceptance by the biocontrol beetle, Cassida rubiginosa. The beetle was released in New Zealand for control of Cirsium arvense, its primary host plant, but has potential to attack many Cardueae (thistles and knapweeds) species. We conducted a series of no‐choice and choice experiments and modelled the responses of Cassida rubiginosa in relation to phylogenetic distance from Cirsium arvense.RESULTSThe olfactory recognition (single odour) and preference (two odours) of the beetle showed a significant phylogenetic relationship. These relationships showed a high degree of correlation with 66.9% of the variation in olfactory recognition and 82.8% of the variation in olfactory preference explained by phylogeny. Where the beetle could contact plants, under no‐choice conditions there was no phylogenetic pattern to host plant acceptance. However, under choice conditions, phylogenetic distance was a strong predictor of feeding and oviposition preference. These relationships showed a high degree of correlation, with 63.4% of the variation in feeding preference, and 89.0% of the variation in oviposition preference, explained by phylogeny.CONCLUSIONSAs far as we are aware, this is the first demonstration of an herbivorous insect that exhibits a phylogenetic pattern to olfactory host plant selection. Host plant utilisation by Cassida rubiginosa in New Zealand will be mostly restricted to Cirsium and Carduus species, with minimal potential for impact on other Cardueae weeds. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Enterolactone and trabectedin suppress epithelial ovarian cancer synergistically via upregulating THBS1
Authors: Zeng Zheng , Lin Caiji , Zhang Meng‐Chun , Kossinna Pathum , Wang Pengfei , Cao Danli , Wang Jiaxing , Xu Mengzhi , Wang Xiaoyu , Li Qing , Xu Xiaohui , Yang Hao , Zhu Songling , Liu Gui‐Rong , Xie Kaihong , Yang Jiaming , Luo Yao , Wang Yao , Zhang Xing‐Hua , Lin Jingwen , Chen Hang , Liu Shu‐Lin , Liu Huidi 
Published: July 2023

AbstractEpithelial ovarian cancer (EOC) is the most common and fatal subtype of ovarian malignancies, with no effective therapeutics available. Our previous studies have demonstrated extraordinary suppressive efficacy of enterolactone (ENL) on EOC. A chemotherapeutic agent, trabectedin (Trabe), is shown to be effective on ovarian cancer, especially when combined with other therapeutics, such as pegylated liposomal doxorubicin or oxaliplatin. Thrombospondin 1 (THBS1), a kind of matrix glycoprotein, plays important roles against cancer development through inhibiting angiogenesis but whether it is involved in the suppression of EOC by ENL or Trabe remains unknown. To test combined suppressive effects of ENL and Trabe on EOC and possible involvement of THBS1 in the anticancer activities of ENL and Trabe. The EOC cell line ES‐2 was transfected with overexpressed THBS1 by lentivirus vector. We employed tube formation assay to evaluate the anti‐angiogenesis activity of ENL and of its combined use with Trabe after THBS1 overexpression and established drug intervention and xenograft nude mouse cancer models to assess the in vivo effects of the hypothesized synergistic suppression between the agents and the involvement of THBS1. Mouse fecal samples were collected for 16S rDNA sequencing and microbiota analysis. We detected strong inhibitory activities of ENL and Trabe against the proliferation and migration of cancer cells and observed synergistic effects between ENL and Trabe in suppressing EOC. ENL and Trabe, given either separately or in combination, could suppress the tube formation capability of human microvascular endothelial cells, and this inhibitory effect became even stronger with THBS1 overexpression. In the ENL plus Trabe combination group, the expression of tissue inhibitor of metalloproteinases 3 and cluster of differentiation 36 was both upregulated, whereas matrix metalloproteinase 9, vascular endothelial growth factor, and cluster of differentiation 47 were all decreased. With the overexpression of THBS1, the results became even more pronounced. In animal experiments, combined use of ENL and Trabe showed superior inhibitory effects to either single agent and significantly suppressed tumor growth, and the overexpression of THBS1 further enhanced the anti‐cancer activities of the drug combination group. ENL and Trabe synergistically suppress EOC and THBS1 could remarkably facilitate the synergistic anticancer effects of ENL and Trabe.
Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice
Authors: Zhai Liping , Pei Hongyan , Shen Heping , Yang Yi , Han Chenyang , Guan Qiaobing 
Published: July 2023

AbstractAim of this research was to examine the impact of paeoniflorin (Pae) in suppressing the occurrence of ferroptosis in individuals with Alzheimer's disease (AD). The study utilized APP/PS1 mice with AD as the experimental subjects. Following the administration of Pae, the cognitive behaviors of mice were evaluated and the key indexes of ferroptosis were measured, as well as levels of oxidative stress (OS). For in‐vitro experiments, Erastin was adopted for inducing the ferroptosis of PC12 cells, and the level of cell ferroptosis was detected after Pae treatment. Pae improved the cognitive ability of AD mice, reduced the level of ferroptosis, decreased the iron ion and MAD levels in brain tissues, and increased SOD expression. In PC12 cells, Pae suppressed the Erastin‐induced ferroptosis, mitigated oxidative damage, and reduced the level of ROS. Based on the findings from our research, it was observed that Pae exhibited a specific binding affinity to P53, leading to the suppression of ferroptosis. This mechanism ultimately resulted in the improvement of nerve injury in mice with AD.
Effect of dietary supplementation with Diuripres® on blood pressure, vascular health, and metabolic parameters in individuals with high‐normal blood pressure or stage I hypertension: The CONDOR randomized clinical study
Authors: Fogacci Federica , Degli Esposti Daniela , Di Micoli Antonio , Fiorini Giulia , Veronesi Maddalena , Borghi Claudio , Cicero Arrigo F. G. 
Published: July 2023

AbstractOur aim was to evaluate if a nutritional intervention with a dietary supplement (Diuripres®) containing magnesium, standardized extract of orthosiphon, hawthorn, and hibiscus could positively affect blood pressure (BP), vascular health, and metabolic parameters in 60 individuals with high‐normal BP or stage I hypertension. Participants followed a low‐fat low‐sodium Mediterranean diet for 4 weeks before being randomly allocated to 8‐week treatment with two pills each day of either Diuripres® or placebo. Diuripres® significantly decreased systolic BP compared to placebo after 4 weeks (3.1 ± 0.8 mmHg; p < 0.05) and more consistently after 8 weeks (3.4 ± 0.9 mmHg; p < 0.05). At 8‐week follow‐up, after correction for multiple testing, dietary supplementation with Diuripres® was associated with significant improvements in diastolic BP (−3.1 ± 0.6 mmHg; p < 0.05), aortic BP (−4.3 ± 0.4 mmHg; p < 0.05), and high‐sensitivity C‐reactive protein (hs‐CRP; 0.04 ± 0.01 mg/dL; p < 0.05) in comparison with baseline. The reductions in diastolic BP (−‐3.8 ± 0.7 mmHg; p < 0.05), aortic BP (−5.2 ± 1.0 mmHg; p < 0.05), and hs‐CRP (−0.03 ± 0.01 mg/dL; p < 0.05) were also significant compared to placebo. Therefore, our study shows that dietary supplementation with Diuripres® may be useful in individuals with high‐normal BP or stage I hypertension.
Nanoscale Vector Magnetometry with a Fiber‐Coupled Diamond Probe
Authors: Liu Hang‐Yu , Liu Wen‐Zhao , Wang Meng‐Qi , Ye Xiang‐Yu , Yu Pei , Sun Hao‐Yu , Liu Zhi‐Xian , Liu Zhao‐Xin , Zhou Jing‐Wei , Wang Peng‐Fei , Shi Fa‐Zhan , Wang Ya 
Published: July 2023

AbstractA nanoscale vector magnetometer is demonstrated by integrating a microfabricated diamond probe with a nanopillar on top of a single‐mode optical fiber. Based on the recently developed self‐aligned patterning techniques, ≈80 nitrogen vacancies are concentrated at a 100 nm2 area at the center of nanopillars to maximize the excitation and collection efficiencies. The spatial resolution of such a fiber‐coupled diamond magnetometer can reach 100 nm for the first time with a sensitivity of 11.27 µT/ for DC magnetic field sensing. In addition, the probe can provide deterministic oriented diamond nanopillars for simplified vector magnetometry. This fiber‐coupled diamond probe is applied to demonstrate the magnetic field imaging of charged electrodes in a confined box. These results mark a decisive step toward fiber‐based applications with nanoscale vector magnetometry capabilities.