bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity of an AS01-adjuvanted respiratory syncytial virus prefusion F (RSVPreF3) vaccine in animal models
Authors: Bouzya Badiaa , Rouxel Ronan Nicolas , Sacconnay Lionel , Mascolo Romuald , Nols Laurence , Quique Stéphanie , François Loïc , Atas Anne , Warter Lucile , Dezutter Nancy , Lorin Clarisse 
Published: September 2023

AbstractRespiratory syncytial virus (RSV) causes a high disease burden in older adults. An effective vaccine for this RSV-primed population may need to boost/elicit robust RSV-neutralizing antibody responses and recall/induce RSV-specific T cell responses. To inform the selection of the vaccine formulation for older adults, RSVPreF3 (RSV fusion glycoprotein engineered to maintain the prefusion conformation) with/without AS01 adjuvant was evaluated in mice and bovine RSV infection-primed cattle. In mice, RSVPreF3/AS01 elicited robust RSV-A/B-specific neutralization titers and RSV F-specific polyfunctional CD4+ T cell responses exceeding those induced by non-adjuvanted RSVPreF3. In primed bovines, RSVPreF3/AS01 tended to induce higher pre-/post-vaccination fold-increases in RSV-A/B-specific neutralization titers relative to non-adjuvanted and Alum-adjuvanted RSVPreF3 formulations, and elicited higher RSV F-specific CD4+ T cell frequencies relative to the non-adjuvanted vaccine. Though AS01 adjuvanticity varied by animal species and priming status, RSVPreF3/AS01 elicited/boosted RSV-A/B-specific neutralization titers and RSV F-specific CD4+ T cell responses in both animal models, which supported its further clinical evaluation as prophylactic candidate vaccine for older adults.
Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome
Authors: Gyöngyösi Mariann , Lukovic Dominika , Mester-Tonczar Julia , Zlabinger Katrin , Einzinger Patrick , Spannbauer Andreas , Schweiger Victor , Schefberger Katharina , Samaha Eslam , Bergler-Klein Jutta , Riesenhuber Martin , Nitsche Christian , Hengstenberg Christian , Mucher Patrick , Haslacher Helmuth , Breuer Monika , Strassl Robert , Puchhammer-Stöckl Elisabeth , Loewe Christian , Beitzke Dietrich , Hasimbegovic Ena , Zelniker Thomas A. 
Published: September 2023

AbstractEpstein–Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less attention. Here we evaluated the reactivation of parvovirus-B19 and several members of the Herpesviridae family (DNA viruses) in patients with long-COVID syndrome. We hypothesized that monovalent COVID-19 vaccines inhibit viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, thereby reducing clinical symptoms. Clinical and laboratory data for 252 consecutive patients with PCR-verified past SARS-CoV-2 infection and long-COVID syndrome (155 vaccinated and 97 non-vaccinated) were recorded during April 2021–May 2022 (median 243 days post-COVID-19 infection). DNA virus–related IgG and IgM titers were compared between vaccinated and non-vaccinated long-COVID patients and with age- and sex-matched non-infected, unvaccinated (pan-negative for spike-antibody) controls. Vaccination with monovalent COVID-19 vaccines was associated with significantly less frequent fatigue and multiorgan symptoms (p < 0.001), significantly less cumulative DNA virus–related IgM positivity, significantly lower levels of plasma IgG subfractions 2 and 4, and significantly lower quantitative cytomegalovirus IgG and IgM and EBV IgM titers. These results indicate that anti-SARS-CoV-2 vaccination may interrupt viral cross-talk in patients with long-COVID syndrome (ClinicalTrials.gov Identifier: NCT05398952).
New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
Authors: Sharma Ashish Kumar , Singh Shivam , Bhat Mehvish , Gill Kartik , Zaid Mohammad , Kumar Sachin , Shakya Anjali , Tantray Junaid , Jose Divyamol , Gupta Rashmi , Yangzom Tsering , Sharma Rajesh Kumar , Sahu Sanjay Kumar , Rathore Gulshan , Chandolia Priyanka , Singh Mithilesh , Mishra Anurag , Raj Shobhit , Gupta Archita , Agarwal Mohit , Kifayat Sumaiya , Gupta Anamika , Gupta Prashant , Vashist Ankit , Vaibhav Parth , Kathuria Nancy , Yadav Vipin , Singh Ravindra Pal , Garg Arun 
Published: September 2023

AbstractCardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial infarction. Both traditional and genetic animal models are: In-vitro: Isolated ventricular Myocytes, Guinea pig papillary muscles, Patch-Clamp Experiments, Porcine Atrial Myocytes, Guinea pig ventricular myocytes, Guinea pig papillary muscle: action potential and refractory period, Langendorff technique, Arrhythmia by acetylcholine or potassium. Acquired arrhythmia disorders: Transverse Aortic Constriction, Myocardial Ischemia, Complete Heart Block and AV Node Ablation, Chronic Tachypacing, Inflammation, Metabolic and Drug-Induced Arrhythmia. In-Vivo: Chemically induced arrhythmia: Aconitine antagonism, Digoxin-induced arrhythmia, Strophanthin/ouabain-induced arrhythmia, Adrenaline-induced arrhythmia, and Calcium-induced arrhythmia. Electrically induced arrhythmia: Ventricular fibrillation electrical threshold, Arrhythmia through programmed electrical stimulation, sudden coronary death in dogs, Exercise ventricular fibrillation. Genetic Arrhythmia: Channelopathies, Calcium Release Deficiency Syndrome, Long QT Syndrome, Short QT Syndrome, Brugada Syndrome. Genetic with Structural Heart Disease: Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block, Preexcitation Syndrome. Arrhythmia in Pluripotent Stem Cell Cardiomyocytes. Conclusion: Both traditional and genetic, experimental models of cardiac arrhythmias’ characteristics and significance help in development of new antiarrhythmic drugs.
Quality of life and mental health outcomes: the role of sociodemographic factors in the Palestinian context
Authors: Bdier Dana , Veronese Guido , Mahamid Fayez 
Published: September 2023

AbstractThe Mental health of Palestinians has been described as among the lowest in the world, with over half of Palestinian adults meeting the diagnostic threshold for depressive symptoms and a significant portion of Palestinians experiencing mental distress and anxiety. The aim of the current study was to test the correlation between quality of life (QoL) and mental health outcomes, and the role of sociodemographic variables in predicting mental health outcomes (depression, anxiety, and stress) among Palestinian adults during a challenging period of political conflict. The sample of our study consisted of 957 participants, 283 males and 674 females they were recruited using online methods; online advertisements, e-mail campaigns and social media. Our findings showed that QoL negatively correlated with stress (r = − 0.43, p < 0.01), anxiety (r = − 0.46, p < 0.01), and depression (r = − 0.47, p < 0.05). Moreover, stress positively correlated with anxiety (r = 0.81, p < 0.01), and depression (r = 0.89, p < 0.01). Finally, anxiety positively correlated with depression (r = 0.82, p < 0.01). Results of hierarchical regression analysis to predict stress, anxiety and depression, indicated that QoL, educational level, gender, region of residence, and age explained in a significant way variance in depression, anxiety and stress. Our findings are promising to conduct other studies in order to understand better how current study variables correlate to each other, so appropriate clinical interventions to mitigate the negative effects of depression, anxiety, and stress through enhancing quality of life and positive coping strategies can be developed and implemented by mental health providers.
Fuzzy variable gain robust control of active magnetic bearings rigid rotor system
Authors: Xu Yuhao , Wang Xiaoyuan , Liu Mingxin , Li Na , Yu Tian 
Published: September 2023

AbstractA high speed rigid rotor system supported by active magnetic bearings (AMBs) puts forward higher requirements on the performance of controllers. The fuzzy variable gain H‐infinity robust control (FVGRC) method is proposed to simplify controller design while suppressing system uncertainty. First, the T‐S fuzzy model of four‐degree‐of‐freedom (4‐DOF) AMBs was established based on the 4‐DOF AMBs rigid rotor equivalent coupling model optimised by the μ‐gap metric. Then, based on the fuzzy models of AMBs systems under different operating conditions, the relative optimal weight function value of H‐infinity robust controller was calculated when AMBs system was at value of the speed endpoint, and the fuzzy variable gain H‐infinity robust (FVGR) controller was designed on this basis. Finally, the simulation and experimental results showed that the FVGRC can simplify the model of controller and ensure the stable operation of AMBs rigid rotor system in the full speed range under high‐speed conditions.
J’attends un parent
Authors: Hattab Jocelyn 
Published: September 2023

Si donner naissance est un choix, le petit d’homme ne peut survivre que si un ou plusieurs adultes assurent sa survie jusqu’à un certain âge selon des facteurs physiologiques et culturels. Ces adultes sont généralement ceux qui ont donné naissance à l’enfant; et leur fonction est d’exercer ce qu’il est convenu d’appeler la parentalité.
À partir de son expérience de consultant dans une institution où des enfants, déclarés adoptables par le tribunal ou recommandés par les services sociaux, attendaient une famille adoptive, l’auteur discute quelques questions soulevées par les situations où se confrontent le désir de parent(s) chez l’enfant et le droit à la parentalité revendiqué par l’adulte.
Après avoir commenté le champ de l’adoption, il évoque les situations très diverses rencontrées autour de formes particulières de parentalité : mères adolescentes, PMA, GPA, « nouvelles familles », mères âgées, co-parentalité.
Il pointe comment chacune de ces situations impose de garder l’intérêt de l’enfant, dès avant sa naissance et tout au long de son développement, au centre de nos réflexions et décisions.
Ten Steps for NPH Management: Advancements in Diagnosis and Treatment of Adult Hydrocephalus
Authors: Roman Alex , Takkar Prince , Maiti Tanmoy 
Published: September 2023

Abstract
Objectives The authors of the present study intend to describe a straightforward protocol for normal pressure hydrocephalus diagnosis and management, with the employment of a multidisciplinary team approach effort.
Methods Using a strict methodological approach for initial diagnosis, taking into consideration occupational therapy and physical therapy assessment, the authors have set out to elaborate a simple protocol for suspicion and, once diagnosed, treatment of normal pressure hydrocephalus. We have used the MoCA (Montreal Cognitive Assessment) and walking assessment that included speed, independence, and distance (SID), 10 m walk test, TUG (timed up and go) evaluation, 6-minute Walk Test, MiniBESTest, as the main factors for pre and post lumbar drainage assessment, after which, the alternatives were deliberated and followed, or not, by ventriculoperitoneal shunt insertion.
Results The authors have described a protocol, consisting of ten easy steps, which involves a multidisciplinary team, including occupational therapy and physical therapy professionals, as well as neurologists and neurosurgeons for improved and objective assessment prior to insertion of lumbar drain and, thereafter, detecting the population at most benefit for ventriculoperitoneal shunt insertion. We have described the Ten Step Approach for Normal Pressure Hydrocephalus management, including from initial clinical presentation and imaging, to pre and post lumbar drainage, for lastly deciding upon necessity for ventriculoperitoneal shunt insertion.
Conclusions A straightforward protocol for normal pressure hydrocephalus seems not only feasible, but simple to implement in most neurosurgical departments, with good accuracy of prediction of lumbar drainage assessment to shunting outcomes.
Exploring the generation, development, and integration of argumentative
goals in L1 and L2 composition processes
Authors: Roca de Larios Julio 
Published: September 2023

The main purpose of this chapter is to critically
examine a number of methodological issues related to the analysis of L1 and
L2 writing processes from a genre-based perspective – a domain of inquiry
that has remained largely underdeveloped in the L2 writing research agenda.
I discuss the range of theoretical assumptions and empirical considerations
that led me to become involved in the research, describe the most relevant
methodological challenges faced when attempting to trace the generation,
elaboration, and integration of writers’ argumentative goals across
languages, and illustrate the decisions I made at these three stages. I
finally evaluate the significance of the analytical categories and
procedures previously discussed and suggest avenues for further
research.
Methodology and multimodality
Authors: Pacheco Mark B. , Smith Blaine E. 
Published: September 2023

This chapter explores methodological challenges in
understanding the relationships between processes, products, and
perspectives within digital multimodal composition. Using examples from a
research project concerning multilingual and multimodal composing in an
eighth-grade classroom in the United States, the authors describe specific
challenges – and possible avenues forward – in relation to screen-capture
software, student retrospective design interviews, and multimodal
timescapes. The chapter concludes with implications from these challenges
for research and instruction for emergent bilingual students.
Surgical navigation for guidewire placement from intraoperative fluoroscopy in orthopaedic surgery
Authors: Mekki L , Sheth N M , Vijayan R C , Rohleder M , Sisniega A , Kleinszig G , Vogt S , Kunze H , Osgood G M , Siewerdsen J H , Uneri A 
Published: September 2023

Abstract

Objective. Surgical guidewires are commonly used in placing fixation implants to stabilize fractures. Accurate positioning of these instruments is challenged by difficulties in 3D reckoning from 2D fluoroscopy. This work aims to enhance the accuracy and reduce exposure times by providing 3D navigation for guidewire placement from as little as two fluoroscopic images. Approach. Our approach combines machine learning-based segmentation with the geometric model of the imager to determine the 3D poses of guidewires. Instrument tips are encoded as individual keypoints, and the segmentation masks are processed to estimate the trajectory. Correspondence between detections in multiple views is established using the pre-calibrated system geometry, and the corresponding features are backprojected to obtain the 3D pose. Guidewire 3D directions were computed using both an analytical and an optimization-based method. The complete approach was evaluated in cadaveric specimens with respect to potential confounding effects from the imaging geometry and radiographic scene clutter due to other instruments. Main results. The detection network identified the guidewire tips within 2.2 mm and guidewire directions within 1.1°, in 2D detector coordinates. Feature correspondence rejected false detections, particularly in images with other instruments, to achieve 83% precision and 90% recall. Estimating the 3D direction via numerical optimization showed added robustness to guidewires aligned with the gantry rotation plane. Guidewire tips and directions were localized in 3D world coordinates with a median accuracy of 1.8 mm and 2.7°, respectively. Significance. The paper reports a new method for automatic 2D detection and 3D localization of guidewires from pairs of fluoroscopic images. Localized guidewires can be virtually overlaid on the patient’s pre-operative 3D scan during the intervention. Accurate pose determination for multiple guidewires from two images offers to reduce radiation dose by minimizing the need for repeated imaging and provides quantitative feedback prior to implant placement.
EAMNet: an Alzheimer’s disease prediction model based on representation learning
Authors: Duan Haoliang , Wang Huabin , Chen Yonglin , Liu Fei , Tao Liang 
Published: September 2023

Abstract

Objective. Brain 18F-FDG PET images indicate brain lesions’ metabolic status and offer the predictive potential for Alzheimer’s disease (AD). However, the complexity of extracting relevant lesion features and dealing with extraneous information in PET images poses challenges for accurate prediction. Approach. To address these issues, we propose an innovative solution called the efficient adaptive multiscale network (EAMNet) for predicting potential patient populations using positron emission tomography (PET) image slices, enabling effective intervention and treatment. Firstly, we introduce an efficient convolutional strategy to enhance the receptive field of PET images during the feature learning process, avoiding excessive extraction of fine tissue features by deep-level networks while reducing the model’s computational complexity. Secondly, we construct a channel attention module that enables the prediction model to adaptively allocate weights between different channels, compensating for the spatial noise in PET images’ impact on classification. Finally, we use skip connections to merge features from different-scale lesion information. Through visual analysis, the network constructed in this article aligns with the regions of interest of clinical doctors. Main results. Through visualization analysis, our network aligns with regions of interest identified by clinical doctors. Experimental evaluations conducted on the ADNI (Alzheimer’s Disease Neuroimaging Initiative) dataset demonstrate the outstanding classification performance of our proposed method. The accuracy rates for AD versus NC (Normal Controls), AD versus MCI (Mild Cognitive Impairment), MCI versus NC, and AD versus MCI versus NC classifications achieve 97.66%, 96.32%, 95.23%, and 95.68%, respectively. Significance. The proposed method surpasses advanced algorithms in the field, providing a hopeful advancement in accurately predicting and classifying Alzheimer’s Disease using 18F-FDG PET images. The source code has been uploaded to https://github.com/Haoliang-D-AHU/EAMNet/tree/master.
Significance of the negative binomial distribution in multiplicity phenomena
Authors: Tezlaf S V 
Published: September 2023

Abstract
The negative binomial distribution (NBD) has been theorized to express a scale-invariant property of many-body systems and has been consistently shown to outperform other statistical models in both describing the multiplicity of quantum-scale events in particle collision experiments and predicting the prevalence of cosmological observables, such as the number of galaxies in a region of space. Despite its widespread applicability and empirical success in these contexts, a theoretical justification for the NBD from first principles has remained elusive for fifty years. The accuracy of the NBD in modeling hadronic, leptonic, and semileptonic processes is suggestive of a highly general principle, which is yet to be understood. This study demonstrates that a statistical event of the NBD can in fact be derived in a general context via the dynamical equations of a canonical ensemble of particles in Minkowski space. These results describe a fundamental feature of many-body systems that is consistent with data from the ALICE and ATLAS experiments and provides an explanation for the emergence of the NBD in these multiplicity observations. Two methods are used to derive this correspondence: the Feynman path integral and a hypersurface parametrization of a propagating ensemble.
Numerical investigation of sonochemical production in a single bubble under dual-frequency acoustic excitation
Authors: Lv Liang , Liu Fei 
Published: September 2023

Abstract
A numerical computation study about sonochemical activity of an oxygen bubble oscillations in a dual-frequency acoustic field is presented in this paper. The variation of excitation frequency causes the change of magnitude and duration of pressure acting on the bubble, affecting the instantaneous bubble radius, internal bubble temperature as well as chemical reactions. The numerical results indicate the formation of O2, HO2
•, •OH, H•, O, H2 and H2O2 in an O2 bubble during oscillations. The main oxidant is •OH radical. The influence of several parameters (e.g. couples of frequencies, the total pressure amplitude and the ratio of pressure amplitudes of the two waves) on the molar yields of free radicals is analyzed. There is an optimum bubble collapse temperature (around 5648 K) for the •OH production. Moreover, the corresponding frequency intervals of enhanced effect and weakened effect under different coupled frequencies (i.e. 40, 140, 213, 355 and 515 kHz) are also investigated.
Influence of gas pressure and gas type on pseudospark electron beam
Authors: Shang Tianyi , Ding Weidong 
Published: September 2023

Abstract
Pseudospark discharge is a discharge that occurs in the left
band of the Paschen curve. According to previous studies, an
electron beam will be generated in the initial stage of pseudospark
discharge. This electron beam has the advantages of high energy,
high current and self-confinement. It has a promising application in
high-power microwave sources, surface treatment of metal materials,
etc. To investigate the characteristics of this electron beam, a
pseudospark discharge experimental platform is established in this
paper. A pseudospark chamber is designed for pseudospark
discharge. To trigger the discharge, a high voltage pulse trigger
signal is generated by an avalanche transistor Marx circuit and a
trigger unit is designed to generate trigger electrons. Faraday Cup
is utilized to collect the electron beam and measure the electron
waveform. In order to quantitatively characterize the electron beam,
we define six electron beam characteristics, including trigger
delay, peak current, electron beam charge, electron beam width,
electron beam loop current ratio and electron beam loop charge
ratio. To investigate the influence of gas pressure and gas type on
electron beam characteristics, we experimentally obtained results of
electron beam characteristics for different gas pressures and gas
type. We mainly investigated the change rule of the electron beam
characteristics when the gas pressure changes between 6 Pa and 20 Pa
and the similarities and differences of the electron beams under the
two gas environments, argon and nitrogen. We find that gas pressure
can be used for the modulation of electron beam time delay. The
width of the electron beam in the case of nitrogen has a very stable
relationship with the gas pressure. Gas pressure and gas type are
two important means of controlling the characteristics of
pseudospark electron beams.