bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acción colectiva sindical, sindicalismo social y libertad de los trabajadores en Nueva Zelandia
Authors: PARKER Jane , ALAKAVUKLAR Ozan 
Published: March 2023

ResumenLa libertad de asociación puede englobar el derecho sindical a emprender acciones colectivas en interés de los afiliados. En ese sentido, se presume que los sindicatos aumentan la libertad de los trabajadores. Sin embargo, no se ha estudiado suficientemente la vinculación entre esa libertad, entendida como realización personal, y la acción colectiva sindical que crea coaliciones con la sociedad civil. Partiendo de los conceptos de libertad de Berlin (1969) y MacCallum (1967), en este artículo se evalúa cómo influyen esas coaliciones en la libertad de los trabajadores. Posteriormente, desde una perspectiva democrática radical (Laclau y Mouffe 2001) de la participación sindical en el movimiento de transición justa en Nueva Zelandia, se examina si los sindicatos amplían esa libertad.
Evaluation of fragmented embryos implantation potential using time‐lapse technology
Authors: Lahav‐Baratz Shirly , Blais Idit , Koifman Mara , Dirnfeld Martha , Oron Galia 
Published: March 2023

AbstractAimTo examine the implantation potential of fragmented embryos that underwent morphokinetic evaluation in a time‐lapse incubator.MethodsA retrospective study analyzing 4210 Day 5 embryos which were incubated in a time‐lapse incubator, between 2013 and 2019. Embryos with more than 5% fragmentation (379 embryos) were included in the study. Embryos selected using the general model and re‐examined by our in‐house model. Embryo fragmentation percentage was documented from the first cell‐division (start fragmentation) to its maximal percentage (final fragmentation), and the ratio between them (fragmentation worsening). Data were analyzed with relation to embryo development, embryos transfer or freezing, clinical pregnancy, and live birth rates.ResultsEmbryo fragmentation and morphokinetics were found to be independent variables for clinical pregnancy achievements. A higher fragmentation worsening was noted among discarded embryos compared to transferred or frozen embryos (p < 0.0001). Advanced maternal age had a significant negative effect on fragmentation (p < 0.001). Missed abortion rates were similar in fragmented embryos that implanted compared with the overall population. Live birth rates were comparable among embryos which were selected for transfer or freezing by their morphokinetics and had different severity of fragmentation.ConclusionOur study shows that fragmented embryos have a potential to implant and therefore should be selected for transfer. Laboratories which do not use time‐lapse incubators for embryo selection, should consider transferring fragmented embryos, since they have an acceptable chance for live birth. Calculation of fragmentation worsening may enhance our ability to predict embryo development. Further research with analysis of more fragmented embryo maybe beneficial. This study was approved by the local ethics committee No. 0010‐19 CMC on April 18th, 2019.
High-Degree Polynomial Integrals of a Natural System on the Two-Dimensional Torus
Authors: Agapov S. V. 
Published: March 2023

AbstractWe study a natural mechanical system on the two-dimensional torus which admits
an additional first integral polynomial in momenta of an odd degree $ N $
and
independent of the energy integral. For $ N=5,7 $, we obtain the estimates
on the number of straight lines in the spectrum of the potential.
Evaluation of bowel preparation regimens for colonoscopy including a novel low volume regimen (Plenvu): CLEANSE study
Authors: Ahmad Ahmir , Marshall Sarah , Bassett Paul , Thiruvilangam Kowshika , Dhillon Angad , Saunders Brian P 
Published: March 2023

BackgroundPoor bowel preparation is the leading cause of failed colonoscopies and increases costs significantly. Several, split preparation, 2 day regimens are available and recently, Plenvu, a low-volume preparation which can be given on 1 day has been introduced.AimsAssess efficacy and tolerability of commonly used purgative regimens including Plenvu.MethodIn this service evaluation, patients undergoing screening colonoscopy at St Mark’s Hospital, London (February 2020–December 2021) were provided Plenvu (1 or 2 days), Moviprep (2 days) or Senna & Citramag (2 days).Boston Bowel Preparation Scale (BBPS) score, fluid volumes and procedure times were recorded. A patient experience questionnaire evaluated taste, volume acceptability, completion and side effects.Results563 patients were invited to participate and 553 included: 218 Moviprep 2 days, 108 Senna & Citramag 2 days, 152 Plenvu 2 days and 75 Plenvu 1 day.BBPS scores were higher with Plenvu 1 and 2 days vs Senna & Citramag (p=0.003 and 0.002, respectively) and vs Moviprep (p=0.003 and 0.001, respectively). No other significant pairwise BBPS differences and no difference in preparation adequacy was seen between the groups.Patients rated taste as most pleasant with Senna & Citramag and this achieved significance versus Plenvu 1 day and 2 days (p=0.002 and p<0.001, respectively) and versus Moviprep (p=0.04).ConclusionBBPS score was higher for 1 day and 2 days Plenvu versus both Senna & Citramag and Moviprep. Taste was not highly rated for Plenvu but it appears to offer effective cleansing even when given as a same day preparation.
Surgery for rheumatic heart disease in the Northern Territory, Australia, 1997–2016: what have we gained?
Authors: Doran James , Canty David , Dempsey Karen , Cass Alan , Kangaharan Nadarajah , Remenyi Bo , Brunsdon Georgie , McDonald Malcolm , Heal Clare , Wang Zhiqiang , Royse Colin , Royse Alistair , Mein Jacqueline , Gray Nigel , Bennetts Jayme , Baker Robert A , Stewart Maida , Sutcliffe Steven , Reeves Benjamin , Doran Upasna , Rankine Patricia , Fejo Richard , Heenan Elisabeth , Jalota Ripudaman , Ilton Marcus , Roberts-Thomson Ross , King Jason , Wyber Rosemary , Doran Jonathan , Webster Andrew , Hanson Joshua 
Published: March 2023

BackgroundBetween 1964 and 1996, the 10-year survival of patients having valve replacement surgery for rheumatic heart disease (RHD) in the Northern Territory, Australia, was 68%. As medical care has evolved since then, this study aimed to determine whether there has been a corresponding improvement in survival.MethodsA retrospective study of Aboriginal patients with RHD in the Northern Territory, Australia, having their first valve surgery between 1997 and 2016. Survival was examined using Kaplan-Meier and Cox regression analysis.FindingsThe cohort included 281 adults and 61 children. The median (IQR) age at first surgery was 31 (18–42) years; 173/342 (51%) had a valve replacement, 113/342 (33%) had a valve repair and 56/342 (16%) had a commissurotomy. There were 93/342 (27%) deaths during a median (IQR) follow-up of 8 (4–12) years. The overall 10-year survival was 70% (95% CI: 64% to 76%). It was 62% (95% CI: 53% to 70%) in those having valve replacement. There were 204/281 (73%) adults with at least 1 preoperative comorbidity. Preoperative comorbidity was associated with earlier death, the risk of death increasing with each comorbidity (HR: 1.3 (95% CI: 1.2 to 1.5), p<0.001). Preoperative chronic kidney disease (HR 6.5 (95% CI: 3.0 to 14.0) p≤0.001)), coronary artery disease (HR 3.3 (95% CI: 1.3 to 8.4) p=0.012) and pulmonary artery systolic pressure>50 mm Hg before surgery (HR 1.9 (95% CI: 1.2 to 3.1) p=0.007) were independently associated with death.InterpretationSurvival after valve replacement for RHD in this region of Australia has not improved. Although the patients were young, many had multiple comorbidities, which influenced long-term outcomes. The increasing prevalence of complex comorbidity in the region is a barrier to achieving optimal health outcomes.
Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With Stroke
Authors: Mayerhofer Ernst , Strecker Christoph , Becker Heiko , Georgakis Marios K. , Uddin Md Mesbah , Hoffmann Michael M. , Nadarajah Niroshan , Meggendorfer Manja , Haferlach Torsten , Rosand Jonathan , Natarajan Pradeep , Anderson Christopher D. , Harloff Andreas , Hoermann Gregor 
Published: March 2023

Background:
Undetermined stroke etiology hampers optimal secondary prevention in a large proportion of young patients. We explored whether genetic screening for clonal hematopoiesis of indetermined potential (CHIP), a novel risk factor for stroke, could identify patients with myeloid precursor lesions or covert myeloid neoplasm requiring specific treatment.

Methods:
We performed targeted sequencing on 56 genes recurrently mutated in hematologic neoplasms in a prospective cohort of patients with acute brain ischemia between 18 and 60 years. CHIP prevalence was compared with age-matched healthy controls from the Nijmegen Biomedical Study (n=1604) and the UK Biobank (n=101 678). Patients with suspicion of high-risk CHIP or myeloid neoplasm were invited for further hematologic evaluation.

Results:

We included 248 consecutive patients (39% women) of whom 176 (71%) had cryptogenic stroke etiology. Fifty-one (21%) patients had CHIP, 3-fold more than in the general population (7.7% versus 2.6% for the Nijmegen Biomedical Study and 11.9% versus 4.1% for UK Biobank;
P
<0.001 for both). Patients with CHIP were older (median [interquartile range], 53 [50–59] versus 51 [41–56] years;
P
<0.001), had higher carotid intima-media thickness (0.68 [0.58–0.80] versus 0.59 [0.51–0.73] mm;
P
=0.009), and had higher burden of atherosclerosis (29.4% versus 16.7%;
P
=0.04). We invited 11 patients (4.4%) for further hematologic assessment, which in 7 led to the diagnosis of high-risk CHIP and in 2 to the new diagnosis of a myeloproliferative neoplasm with indication for cytoreductive therapy.

Conclusions:
Using genetic screening for myeloid disorders in patients with stroke of predominantly undetermined etiology, we found a 3-fold higher CHIP prevalence than in the general population. We identified high-risk CHIP and previously covert myeloproliferative neoplasms as potential stroke etiologies in 4.4% and 1% of patients, respectively. Our findings demonstrate the diagnostic and therapeutic yield of genetic screening in young patients with stroke. Future studies should investigate the role of CHIP for stroke recurrence and optimal secondary prevention.
Palliative care referral criteria and application in pediatric illness care: A scoping review
Authors: Bernier Carney Katherine M. , Goodrich George , Lao Amberly , Tan Zewen , Kiza Alfred Habamutaki , Cong Xiaomei , Hinderer Katherine A. 
Published: March 2023

Background: Specialty pediatric palliative care services can help to address unmet care needs for children with complex and serious illness. Current guidelines support the identification of unmet palliative care needs; however, it is unknown how these guidelines or other clinical characteristics influence pediatric palliative care referral in research and practice. Aim: To evaluate the identification and application of palliative care referral criteria in pediatric illness care and research. Design: A scoping review with a content analysis approach to summarize results. Data sources: Five electronic databases (PubMed, CINAHL, PsycINFO, SCOPUS, and Academic Search Premier) were used to identify peer-reviewed literature published in English between January 2010 and September 2021. Results: We included 37 articles focused on the referral of pediatric patients to palliative care teams. The identified categories of referral criteria were: disease-related; symptom-related; treatment communication; psychosocial, emotional, and spiritual support; acute care needs; end-of-life care needs; care management needs; and self-referrals for pediatric palliative care services. We identified two validated instruments to facilitate palliative care referral and seven articles which described population-specific interventions to improve palliative care access. Nineteen articles implemented a retrospective health record review approach that consistently identified palliative care needs with varying rates of service use. Conclusions: The literature demonstrates inconsistent methods for identifying and referring children and adolescents with unmet palliative care needs. Prospective cohort studies and clinical trials would inform more consistent pediatric palliative care referral practices. More research is needed on palliative care referral and outcomes in community-focused pediatrics.
Phthalonitrile resin reinforced silane surface modified boron carbide: Efficient neutrons screening and exceptional thermal properties
Authors: Abdous Slimane , Derradji Mehdi , Mehelli Oussama , Khiari Karim , Kadi Mohamed Elamine , Habes Abdelmalek , Ramdani Noureddine , Zegaoui Abdeljalil , Liu Wenbin 
Published: March 2023

The design of lightweight neutron shields has been restricted for quite some time to the use of epoxy thermosets as the main building blocks. Meanwhile, the recent developments in the field of polymers suggest otherwise. Indeed, the phthalonitrile (PN) resins have taken the lead over traditional thermosets in many demanding applications. Therefore, in a vision to introduce newer matrices with better performances and to further expand the applications of the PN resins into the nuclear field, the neutron shielding efficiency along with the thermal resistance performances of the neat PN polymer and its subsequent silane surface-modified B4C-reinforced composites were investigated. The neutron shielding measurements were performed using an optimized experimental setup at the NUR research reactor in Algiers. The neat PN polymer displayed better thermal neutron screening performances than the epoxy and benzoxazine, with a macroscopic cross-section (Σ) of a 1.936 cm−1, equivalent to a mean free path (λ) of 0.358 cm. The effect of the particle amount was also studied to maximize the shielding ability of the developed materials. For instance, the PN composite containing 20 wt. % of B4C displayed an outstanding screening ratio of about 99.8% for a sample thickness of 13 mm. Finally, the remarkable findings were put into context by providing multifaceted comparisons with the available shielding materials.
Beyond burnout II: A case series of doctors seen in a new publicly funded doctors’ mental health service
Authors: Lele Kiran , Mclean Loyola M , Peisah Carmelle 
Published: March 2023

Objective Doctors’ mental health has received increased focus recently and has been met with a variety of systemic responses. A Professional Support Unit (PSU) in a public hospital was established to address service gaps. This paper aims to describe the care of doctors referred to this service. Methods Participants in the first four cases were referred to the PSU and assessed by the first author. Results The cases revealed: (i) variety of referral sources, symptom presentations and backgrounds of doctors referred to a dedicated doctors’ health service; and (ii) the person-centred, multi-modal treatments and adjunctive services required. Conclusion Doctors’ mental health is an urgent priority, with direct impacts on patient safety and care. The mix of patients presented here suggest difficulties beyond burnout and highlight the workings of a new service model designed to complement existing services in the Australian context.
Risk factors of loss of reduction after acromioclavicular joint dislocation treated with a hook plate
Authors: Lee Young Seok , Kim Doo Sup , Jung Ji Won , Jo Young-Hoon , Lee Chang-Hun , Lee Bong Gun 
Published: March 2023

Abstract
Background
Acromioclavicular joint fixation using a hook plate is effective for the treatment of acute acromioclavicular joint dislocation. However, several studies have reported some complications including loss of reduction after surgery for acromioclavicular joint dislocation. This study aimed to identify the risk factors associated with the loss of reduction after acromioclavicular joint dislocation surgery using a hook plate.

Methods
This was a retrospective study that assessed 118 patients with acromioclavicular joint dislocation, who were diagnosed between March 2013 and January 2019 and underwent surgical treatment using the hook plate (reduction loss group: n = 38; maintenance group: n = 80). The mean follow-up period was 29.9 months (range, 24–40 months). We assessed the range of motion, the American Shoulder and Elbow Surgeons score (ASES), visual analog scale score for pain, and a subjective shoulder value. Radiological assessment of coracoid clavicular distance was performed. The risk factors of reduction loss were analyzed using multivariable logistic regression analysis.

Results
Age (p = 0.049), sex (female, p = 0.03, odds ratio OR = 4.81), Rockwood type V (p = 0.049, OR = 2.20), and time from injury to surgery > 7 days (p = 0.018, OR = 2.59) were statistically significant factors in the reduction loss group. There were no significant differences in the clinical outcomes for range of motion, ASES, subjective shoulder value, and visual analog scale scores between the two groups. In the radiological results, preoperative coracoid clavicular distance (p = 0.039) and ratio (p = 0.001), and over-reduction (p = 0.023, OR = 0.40) were significantly different between the two groups. The multivariate logistic regression analysis identified the female sex (p = 0.037, OR = 5.88), a time from injury to surgery > 7 days (p = 0.019, OR = 3.36), and the preoperative coracoid clavicular displacement ratio of the injured shoulder (p < 0.001, OR = 1.03) as risk factors associated with reduction loss following surgery using a hook plate for acromioclavicular dislocation.

Conclusion
A delayed timing of surgery > 7 days, preoperative coracoid clavicular displacement ratio of the injured shoulder, and female sex were identified as risk factors for loss of reduction after surgery using a hook plate for acromioclavicular joint dislocation.
Level of evidence: Level IV; retrospective comparison; treatment study
α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways
Authors: Alrasheed Nawal M. , Alammari Raghad B. , Alshammari Tahani K. , Alamin Maha A. , Alharbi Abeer O. , Alonazi Asma S. , Bin Dayel Anfal F. , Alrasheed Nouf M. 
Published: March 2023

Abstract
Background
Myocardial infarction (MI) is considered a public health problem. According to the World Health Organization, MI is a leading cause of death and comorbidities worldwide. Activation of the α1A adrenergic receptor is a contributing factor to the development of MI. Tamsulosin, an α1A adrenergic blocker, has gained wide popularity as a medication for the treatment of benign prostatic hyperplasia. Limited evidence from previous studies has revealed the potential cardioprotective effects of tamsulosin, as its inhibitory effect on the α1A adrenoceptor protects the heart by acting on the smooth muscle of blood vessels, which results in hypotension; however, its effect on the infarcted heart is still unclear. The mechanisms of the expected cardioprotective effects mediated by tamsulosin are not yet understood. Transforming growth factor-beta (TGF-β), a mediator of fibrosis, is considered an attractive therapeutic target for remodeling after MI. The role of α1A adrenoceptor inhibition or its relationships with integrin-linked kinase (ILK) and TGF-β/small mothers against decapentaplegic (Smad) signaling pathways in attenuating MI are unclear. The present study was designed to investigate whether tamsulosin attenuates MI by modulating an ILK-related TGF-β/Smad pathway.

Methods
Twenty-four adult male Wistar rats were randomly divided into 4 groups: control, ISO, TAM, and ISO + TAM. ISO (150 mg/kg, intraperitoneally) was injected on Days 20 and 21 to induce MI. Tamsulosin (0.8 mg/kg, orally) was administered for 21 days, prior to ISO injection for 2 consecutive days. Heart-to-body weight ratios and cardiac and fibrotic biomarker levels were subsequently determined. ILK, TGF-β1, p-Smad2/3, and collagen III protein expression levels were determined using biomolecular methods.

Results
Tamsulosin significantly attenuated the relative heart-to-body weight index (p < 0.5) and creatine kinase-MB level (p < 0.01) compared with those in the ISO control group. While ISO resulted in superoxide anion production and enhanced oxidative damage, tamsulosin significantly prevented this damage through antioxidant defense mechanisms, increasing glutathione and superoxide dismutase levels (p < 0.05) and decreasing lipid peroxide oxidation levels (p < 0.01). The present data revealed that tamsulosin reduced TGF-β/p-Smad2/3 expression and enhanced ILK expression.

Conclusion
Tamsulosin may exert a cardioprotective effect by modulating the ILK-related TGF-β/Smad signaling pathway. Thus, tamsulosin may be a useful therapeutic approach for preventing MI.
Utilizing ultrasound in suspected necrotizing enterocolitis with equivocal radiographic findings
Authors: Kallis Michelle P. , Roberts Bailey , Aronowitz Danielle , Shi Yan , Lipskar Aaron M. , Amodio John B. , Aggarwal Alpna , Sathya Chethan 
Published: March 2023

Abstract
Background
To examine the use of abdominal ultrasound (AUS) as a diagnostic adjunct in the diagnosis of necrotizing enterocolitis (NEC) in cases where abdominal radiography (AXR) is equivocal in order to reduce unnecessary antibiotic use in neonates.

Methods
Retrospective study (2017–2019) of infants undergoing NEC evaluation with equivocal AXR findings (n = 54). Paired AXR and AUS were reviewed with respect to presence or absence of pneumatosis. Concordance of AUS findings with decision to treat for NEC was evaluated.

Results
Among 54 infants where AXR was equivocal, AUS demonstrated presence of pneumatosis in 22 patients (41%), absence of pneumatosis in 31 patients (57%), and was equivocal in 1 patient. All patients with pneumatosis on AUS were treated for NEC. Of 31 patients without pneumatosis on AUS, 25 patients (78%) were not treated for NEC. Patients without pneumatosis on AUS received a significantly shorter mean duration of antibiotics compared to those with pneumatosis (3.3 days (+/− 4.8 days) vs 12.4 days (+/− 4.7 days)); p < 0.001). Of those patients not treated, none required treatment within 1 week following negative AUS.

Conclusion
AUS is a valuable tool for evaluating the presence or absence of pneumatosis in the setting of equivocal AXR. Absence of pneumatosis on AUS informs clinical decision making and reduces unnecessary treatment and antibiotic usage.