bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Characterization of Fatigue and Cyclic Plasticity of 304L Stainless Steel at Elevated Temperature
Authors: Subasic M. , Alfredsson B. , Dahlberg C. F. O. , Öberg M. , Efsing P. 
Published: September 2023

Abstract
Background
The mechanical characterization of the cyclic elastoplastic response of structural materials at elevated temperatures is crucial for understanding and predicting the fatigue life of components in nuclear reactors.

Objective
In this study, a comprehensive mechanical characterization of 304L stainless steel has been performed including metallography, tensile tests, fatigue tests, fatigue crack growth tests and cyclic stress-strain tests.

Methods
Isothermal tests were conducted at both room temperature and 300 °C for both the rolling direction and the transverse direction of the hot rolled steel. Mechanical properties were extracted from the uniaxial experiments by fitting relevant material models to the data. The cyclic plasticity behavior has been modelled with a radial return-mapping algorithm that utilizes the Voce nonlinear isotropic hardening model in combination with the Armstrong-Frederick nonlinear kinematic hardening model. The plasticity models are available in commercial FE software and accurately capture the stabilized hysteresis loops, including a substantial Bauschinger effect.

Results
The material exhibits near isotropic properties, but its mechanical performance is generally reduced at high temperatures. Specifically, in the rolling direction, the Young’s modulus is reduced by 16 % at 300 °C, the yield strength at 0.2 % plastic strain is lower by 23 %, and the ultimate tensile strength is lower by 30 % compared to room temperature. Fatigue life is also decreased, leading to an accelerated fatigue crack growth rate compared to room temperature. A von Mises radial return mapping algorithm proves to be effective in accurately modelling the cyclic plasticity of the material. The algorithm has also been used to establish a clear correlation between energy dissipation per cycle and cycles to failure, leading to the proposal of an energy-based fatigue life prediction model.

Conclusions
The material exhibits reduced mechanical performance at elevated temperatures, with decreased monotonic strength, compared to room temperature. Fatigue life is also compromised, resulting in accelerated fatigue crack growth. The material’s hardening behavior differs at room temperature and elevated temperature, with lower peak stress values observed at higher temperatures. The radial return mapping algorithm can be used to determine the dissipated energy per cycle which together with fatigue testing has been used to propose a low cycle fatigue life prediction model at both temperatures.
The Question of the Origins of COVID-19 and the Ends of Science
Authors: Komesaroff Paul A. , Dwyer Dominic E. 
Published: September 2023

AbstractIntense public interest in scientific claims about COVID-19, concerning its origins, modes of spread, evolution, and preventive and therapeutic strategies, has focused attention on the values to which scientists are assumed to be committed and the relationship between science and other public discourses. A much discussed claim, which has stimulated several inquiries and generated far-reaching political and economic consequences, has been that SARS-CoV-2 was deliberately engineered at the Wuhan Institute of Virology and then, either inadvertently or otherwise, released to the public by a laboratory worker. This has been pursued despite a clear refutation, through comprehensive genomic analysis, of the hypothesis that the virus was deliberately engineered and the failure of detailed investigations to identify any evidence in support of a laboratory leak. At the same time a substantial, established body of knowledge about the many factors underlying the emergence of novel zoonotic diseases has been largely ignored—including climate change and other mechanisms of environmental destruction, tourism, patterns of trade, and cultural influences. The existence and conduct of these debates have raised questions about the vulnerability of science to manipulation for political purposes. Scientific discourses are vulnerable because: (i) claims can be made with no more than probabilistic force; (ii) alleged “facts” are always subject to interpretation, which depends on social, ethical, and epistemological assumptions; and (iii) science and scientists are not inherently committed to any single set of values and historically have served diverse, and sometimes perverse, social and political interests. In the face of this complexity, the COVID-19 experience highlights the need for processes of ethical scrutiny of the scientific enterprise and its strategic deployment. To ensure reliability of truth claims and protection from corrupting influences robust ethical discourses are required that are independent of, and at times even contrary to, those of science itself.
Cardioprotective effect of St. Thomas’ Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice
Authors: Fujii Masahiro , Bessho Ryuzo , Akimoto Toshio , Ishii Yosuke 
Published: September 2023

Abstract
Objective
This study aimed to investigate whether St. Thomas’ Hospital No. 2 solution (STH2) is equally effective in both young and aged aquaporin-7-knockout (AQP7-KO) mice and the mechanisms by which the intra-myocardial adenosine triphosphate (ATP) content is altered during ischemia without aquaporin-7.

Methods
In study 1, isolated hearts of male wild-type (WT) and AQP7-KO mice (< 12 weeks old) were Langendorff perfused with 5-min STH2 prior to a 20-min global ischemia (GI) or 25-min GI without STH2. Similarly, in Study 2, hearts from WT and AQP7-KO mice (≥ 24 weeks old) were subjected to 2-min STH2 infusion prior to GI. In study 3, intra-myocardial ATP content was compared before (sham) and after (control or STH2) ischemia in mature WT and AQP7-KO mice.

Results
In study 1, troponin T levels (ng/g wet weight) of WT and AQP7-KO hearts were significantly lower in the STH2 groups (75.6 ± 45.9 and 80.2 ± 52.2, respectively) than in the GI groups (934.0 ± 341.1 and 1089.3 ± 182.5, respectively). In Study 2, troponin T levels in aged WT and AQP7-KO mice were 566.5 ± 550.0 and 547.8 ± 594.3, respectively (p = 0.9561). In Study 3, ATP levels (μmol/g protein) in the sham, control, and STH2 AQP7-KO mice groups were 4.45, 2.57, and 3.37, respectively(p = 0.0005).

Conclusions
The present study revealed the cardio-protective efficacy of STH2 in an experimental model of isolated AQP7-KO young and aged murine hearts. Further, STH2 preserved intra-myocardial ATP during ischemia with Krebs–Henseleit buffer perfusion in the Langendorff setting.
Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images
Authors: Nakajima Kenichi , Miyauchi Hideyuki , Hirano Ken-ichi , Fujimoto Shinichiro , Kawahito Michitomo , Iimori Takashi , Kudo Takashi 
Published: September 2023

AbstractThe purpose of this practice recommendation is to specifically identify the critical steps involved in performing and interpreting 123I-β-methyl-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and measurement of washout rate (WR) from the heart. This document will cover backgrounds, patient preparation, testing procedure, visual image interpretation, quantitation methods using planar and SPECT studies, and reporting of WR. The pitfall and some tips for the calculation of 123I-BMIPP WR are also included. The targets of global and regional WR calculation include ischemic heart disease, cardiomyopathy, heart failure, and triglyceride deposit cardiomyovasculopathy, an emerging rare heart disease.
Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism
Authors: Kuhn Madison K. , Fleeman Rebecca M. , Beidler Lynne M. , Snyder Amanda M. , Chan Dennis C. , Proctor Elizabeth A. 
Published: September 2023

Abstract
Introduction
Neuroinflammation and metabolic dysfunction are early alterations in Alzheimer’s disease (AD) brain that are thought to contribute to disease onset and progression. Glial activation due to protein deposition results in cytokine secretion and shifts in brain metabolism, which have been observed in AD patients. However, the mechanism by which this immunometabolic feedback loop can injure neurons and cause neurodegeneration remains unclear.

Methods
We used Luminex XMAP technology to quantify hippocampal cytokine concentrations in the 5xFAD mouse model of AD at milestone timepoints in disease development. We used partial least squares regression to build cytokine signatures predictive of disease progression, as compared to healthy aging in wild-type littermates. We applied the disease-defining cytokine signature to wild-type primary neuron cultures and measured downstream changes in gene expression using the NanoString nCounter system and mitochondrial function using the Seahorse Extracellular Flux live-cell analyzer.

Results
We identified a pattern of up-regulated IFNγ, IP-10/CXCL10, and IL-9 as predictive of advanced disease. When healthy neurons were exposed to these cytokines in proportions found in diseased brain, gene expression of mitochondrial electron transport chain complexes, including ATP synthase, was suppressed. In live cells, basal and maximal mitochondrial respiration were impaired following cytokine stimulation.

Conclusions
We identify a pattern of cytokine secretion predictive of progressing amyloid-β pathology in the 5xFAD mouse model of AD that reduces expression of mitochondrial electron transport complexes and impairs mitochondrial respiration in healthy neurons. We establish a mechanistic link between disease-specific immune cues and impaired neuronal metabolism, potentially causing neuronal vulnerability and susceptibility to degeneration in AD.
Using packet trimming at the edge for in-network video quality adaption
Authors: Tüker Mustafa , Karakış Emre , Sayıt Müge , Clayman Stuart 
Published: September 2023

AbstractThis paper describes the effects of running in-network quality adaption by trimming the packets of layered video streams at the edge. The video stream is transmitted using the BPP transport protocol, which is like UDP, but has been designed to be both amenable to trimming and to provide low-latency and high reliability. The traffic adaption uses the Packet Wash process of Big Packet Protocol (BPP) on the transmitted Scalable Video Coding (SVC) video streams as they pass through a network function which is BPP-aware and embedded at the edge. Our previous work has either demonstrated the use of Software Defined Networking (SDN) controllers to implement Packet Wash directly, or the use of a network function in the core of the network to do the same task. This paper presents our effort to deploy and evaluate such a process at the edge, highlighting the packet trimming algorithm and showing the packet trimming effects on the streams. We compare the performance of transmitting video using BPP and the Packet Wash trimming, against alternative transmission schemes, namely UDP and HTTP adaptive streaming (HAS), presenting a number of quality parameters. The results demonstrate that providing traffic engineering using in-network quality adaption using packet trimming, provides high quality at the receiver.
The Case of the Jeffreys-Lindley-paradox as a Bayes-frequentist Compromise: A Perspective Based on the Rao-Lovric-Theorem
Authors: Kelter Riko 
Published: September 2023

AbstractTesting a precise hypothesis can lead to substantially different results in the frequentist and Bayesian approach, a situation which is highlighted by the Jeffreys-Lindley paradox. While there exist various explanations why the paradox occurs, this article extends prior work by placing the less well-studied point-null-zero-probability paradox at the center of the analysis. The relationship between the two paradoxes is analyzed based on accepting or rejecting the existence of precise hypotheses. The perspective provided in this paper aims at demonstrating how the Bayesian and frequentist solutions can be reconciled when paying attention to the assumption of the point-null-zero-probability paradox. As a result, the Jeffreys-Lindley-paradox can be reinterpreted as a Bayes-frequentist compromise. The resolution shows that divergences between Bayesian and frequentist modes of inference stem from (a) accepting the existence of a precise hypothesis or not, (b) the assignment of positive measure to a null set and (c) the use of unstandardized p-values or p-values standardized to tail-area probabilities.
Sneaky emotions: impact of data partitions in affective computing experiments with brain-computer interfacing
Authors: Moreno-Alcayde Yoelvis , Traver V. Javier , Leiva Luis A. 
Published: September 2023

AbstractBrain-Computer Interfacing (BCI) has shown promise in Machine Learning (ML) for emotion recognition. Unfortunately, how data are partitioned in training/test splits is often overlooked, which makes it difficult to attribute research findings to actual modeling improvements or to partitioning issues. We introduce the “data transfer rate” construct (i.e., how much data of the test samples are seen during training) and use it to examine data partitioning effects under several conditions. As a use case, we consider emotion recognition in videos using electroencephalogram (EEG) signals. Three data splits are considered, each representing a relevant BCI task: subject-independent (affective decoding), video-independent (affective annotation), and time-based (feature extraction). Model performance may change significantly (ranging e.g. from 50% to 90%) depending on how data is partitioned, in classification accuracy. This was evidenced in all experimental conditions tested. Our results show that (1) for affective decoding, it is hard to achieve performance above the baseline case (random classification) unless some data of the test subjects are considered in the training partition; (2) for affective annotation, having data from the same subject in training and test partitions, even though they correspond to different videos, also increases performance; and (3) later signal segments are generally more discriminative, but it is the number of segments (data points) what matters the most. Our findings not only have implications in how brain data are managed, but also in how experimental conditions and results are reported.
A computer vision sensor for the parallelization of actively regulated capillary slug flow microreactors
Authors: Gladius Anoj Winston , Mylenbusch Jonas A. , Agar David William 
Published: September 2023

AbstractIn this work, a computer vision sensor for the extraction of slug length, slug velocity and phase ratio from capillary liquid–liquid slug flows from video feeds in real-time, including the necessary post-processing algorithms, is developed. The developed sensor is shown to be capable of simultaneously monitoring multiple capillaries and provides reasonable accuracy at less than 3.5% mean relative error. Subsequently, the sensor is used for the control of a parallelized and actively regulated dual-channel slug flow capillary microreactor setup. As a model reaction, the solvent-free epoxidation of methyl oleate with hydrogen peroxide and a phase-transfer catalyst based on tungstophosphoric acid and a quaternary ammonium salt to yield the product 9,10-epoxystearic acid methyl ester is conducted. A space–time yield of 0.679 kg L−1 h−1is achieved.
Evaluation of a PlayPosit guided group project’s impact on student engagement in an undergraduate course
Authors: Sherifi Dasantila , Jia Yuane , Hunt Thomas J. , Ndanga Memory 
Published: September 2023

AbstractStudent engagement is critical for meaningful learning and can be impacted by teaching methods, tools, and course content. Online student engagement continues to be challenging because online classes offer fewer ways to engage with professors, peers, and the university than in-person classes. PlayPosit is a video teaching tool that incorporates questions to check for understanding. Our study aimed to evaluate how a PlayPosit guided group project impacted engagement in a structured online learning environment. For this qualitative study, a PlayPosit guided group project was implemented in an online undergraduate course taught via Canvas learning management system. Engagement was evaluated using online course analytics and student’s written feedback. Canvas reports were analyzed using descriptive statistics, and students’ written feedback was analyzed using directed content analysis. All 29 students enrolled in the course completed the course successfully. They completed 99.3% of the PlayPosit activities with accuracy 87.6–100% and completed the course project with scores 89–100%. Student comments were grouped into themes related to PlayPosit, group project, and engagement. Students found PlayPosit activities helpful/beneficial, aligned with deliverables, a great learning resource, and enjoyable. Students recognized the group project for its importance in teaching them collaboration, expressed that it enabled them to learn more from each-other, was an enjoyable networking experience, and was challenging. Engagement themes included knowledge gained was applicable to the real world, the course stimulated higher-order thinking, and the course was enjoyable and kept students wanting more. This study suggested that a PlayPosit guided group project was well-received by students and contributed to high engagement with the content, peers, and the professor.
Navigating the Storm: An Exquisite Leadership Insight into Healthcare Management amidst the COVID-19 Pandemic
Authors: Bhat Zahid Hussain , Bhat Javaid Ahmad , Saba Nuzhat 
Published: September 2023

AbstractThis article presents a reflective analysis of the role of public leadership within the context of crises, advocating for increased involvement of public health experts in crisis management. The study delves into the intricate dynamics that executives and board members exhibit when faced with crises. A primary focus of this research is the essential aspects that illuminate the engagement of public officials in the ongoing crisis, notably rapid decision-making and innovative thinking. The article underscores the paramount importance of leaders emphasizing values and mission while employing clear, meaningful, and empathetic communication. A comprehensive comprehension of public leadership emerges as a pivotal factor in crisis management, particularly when devising policy remedies for public health emergencies. The criticality of nurturing a new generation of healthcare CEOs and elevating the visibility of public health roles is underscored as an imperative for adeptly addressing the array of crises confronting us. This article broadens our insights into the multifaceted responsibilities of human resource management in both crisis response and recovery. Consequently, this endeavor facilitates the identification of evolving leadership roles essential for efficacious crisis management, fostering preparedness for prospective public health challenges.
A New Experience in the Turkish Health System in Response to COVID-19
Authors: Kıran Şafak , Bostan Sedat 
Published: September 2023

Abstract

Objective:
A substantial amount of work addressing strategies on how to respond to the coronavirus disease (COVID-19) crisis already exists. However, there is simply not enough evidence to support a systematic and all-encompassing approach. This study aims to systematically review and present the roadmap of Turkiye’s response to COVID-19.

Methods:
This study is based on a thematic content analysis of official policy documents to present the roadmap in Turkiye’s fight against COVID-19. The analysis included 46 press releases accessed from the Ministry of Health’s website. The coding structure was created by the researchers based on the literature. Documents were analyzed by dividing them into 3 periods: the panic period, the controlled normalization period, and the normalization period. Each document was sub-coded under the main themes of “concerns” and “strategies” and interpreted by comparing them with each other.

Results:
The study results show that different categories and coding structures were formed between periods. Some categories that emerged under the theme of concerns were “vaccine concerns” and “social concerns.” Similarly, some categories that appeared under the theme of strategies were “vaccine strategies,” “monitoring and surveillance strategies,” and “intervention strategies.”

Conclusion:
The results provide policy-makers with an appropriate conceptual framework to deal with the pandemic crisis that may be encountered in the future.
Analysis of microbiological tests in patients withholding or withdrawing life-sustaining treatment at the end stage of life in 2 Korean hospitals
Authors: Bae Sohyun , Kwon Ki Tae , Hwang Soyoon , Kim Yoonjung , Chang Hyun-Ha , Kim Shin-Woo , Lee Nan Young , Kim Yu Kyoung , Lee Je Chul 
Published: September 2023

AbstractObjective:We evaluated the adequacy of microbiological tests in patients withholding or withdrawing life-sustaining treatment (WLST) at the end stage of life.Setting:The study was conducted at 2 tertiary-care referral hospitals in Daegu, Republic of Korea.Design:Retrospective cross-sectional study.Methods:Demographic findings, clinical and epidemiological characteristics, statistics of microbiological tests, and microbial species isolated from patients within 2 weeks before death were collected in 2 tertiary-care referral hospitals from January to December 2018. We also reviewed the antimicrobial treatment that was given within 3 days of microbiological testing in patients on WLST.Results:Of the 1,187 hospitalized patients included, 905 patients (76.2%) had WLST. The number of tests per 1,000 patient days was higher after WLST than before WLST (242.0 vs 202.4). Among the category of microbiological tests, blood cultures were performed most frequently, and their numbers per 1,000 patient days before and after WLST were 95.9 and 99.0, respectively. The positive rates of blood culture before and after WLST were 17.2% and 18.0%, respectively. Candida spp. were the most common microbiological species in sputum (17.4%) and urine (48.2%), and Acinetobacter spp. were the most common in blood culture (17.3%). After WLST determination, 70.5% of microbiological tests did not lead to a change in antibiotic use.Conclusions:Many unnecessary microbiological tests are being performed in patients with WLST within 2 weeks of death. Microbiological testing should be performed carefully and in accordance with the patient’s treatment goals.
Moving boundaries on what I-O has been, and what I-O can be: The United Nations Sustainable Development Goals as an organizing framework
Authors: Mullins Morrie , Olson-Buchanan Julie 
Published: September 2023

AbstractEven before the onset of the COVID-19 pandemic, and especially since, I-O psychology has demonstrated its ability to adapt and to make meaningful contributions to how work is accomplished in tumultuous environments. Such contributions reflect the ongoing evolution of the field and an increased awareness of the potential for I-O psychologists to effect meaningful societal change. We believe that I-O psychology must embrace this evolution and, using the United Nations Sustainable Development Goals to help us target our efforts, become a resource and a voice for workers and organizations around the world, and a force for the greater good.