bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Conversational Interaction in English Between Teachers And Students at High Schools in Dong Nai
Authors: Toan Ly Ngoc 
Published: August 2023

Abstract
The main objective of this study is to enhance the proficiency of conversational interaction in English between teachers and students at high schools situated in the Dong Nai province. The research framework is grounded on Vygotsky's sociocultural theory, supplemented by Long's theory of interaction, and Brown's approach to teaching communicative English. Through a survey of 148 English teachers in Dong Nai high schools and subsequent data analysis employing SPSS 20 software, the research findings indicate that all four factors, namely belonging, expectation, relationship, and motivation, exert a positive and statistically significant influence on conversational interaction in English between teachers and students in this educational context. Based on the study's outcomes, the author proposes several viable strategies to enhance teachers' capacity for conversational interaction in English with their students. Such interventions are envisioned to be instrumental in elevating the overall educational quality, aligning it with international standards, and fostering heightened competitiveness with developed nations within the region. This endeavor represents a concerted effort to contribute to the ongoing advancement of language education in Vietnam.
Assessing Resolvability, Parsability, and Consistency of RDF Resources: A Use Case in Rare Diseases
Authors: Zhang Shuxin , Benis Nirupama , Cornet Ronald 
Published: August 2023

Abstract
Introduction: Healthcare data and the knowledge gleaned from it play a key role in improving the health of current and future patients. These knowledge sources are regularly represented as ‘linked’ resources based on the Resource Description Framework (RDF). Making resources ‘linkable' to facilitate their interoperability is especially important in the rare-disease domain, where health resources are scattered and scarce. However, to benefit from using RDF, resources need to be of good quality. Based on existing metrics, we aim to assess the quality of RDF resources related to rare diseases and provide recommendations for their improvement.
Methods: Sixteen resources of relevance for the rare-disease domain were selected: two schemas, three metadatasets, and eleven ontologies. These resources were tested on six objective metrics regarding resolvability, parsability, and consistency. Any URI that failed the test based on any of the six metrics was recorded as an error. The error count and percentage of each tested resource were recorded. The assessment results were represented in RDF, using the Data Quality Vocabulary schema.
Results: For three out of the six metrics, the assessment revealed quality issues. Eleven resources have non-resolvable URIs with proportion to all URIs ranging from 0.1% (6/6,712) in the Anatomical Therapeutic Chemical Classification to 13.7% (17/124) in the WikiPathways Ontology; seven resources have undefined URIs; and two resources have incorrectly used properties of the ‘owl:ObjectProperty’ type. Individual errors were examined to generate suggestions for the development of high-quality RDF resources, including the tested resources.
Conclusion: We assessed the resolvability, parsability, and consistency of RDF resources in the rare-disease domain, and determined the extent of these types of errors that potentially affect interoperability. The qualitative investigation on these errors reveals how they can be avoided. All findings serve as valuable input for the development of a guideline for creating high-quality RDF resources, thereby enhancing the interoperability of biomedical resources.
Optimization of Heating Temperature on the Growth of Manganese Sulfide Nanosheets Binder-free Electrode for Supercapattery
Authors: Rosli M. I. , Omar F. S. , Awang R. , Saidi Norshahirah M. 
Published: August 2023

Abstract
Supercapattery has emerged as one of the possibilities in the electrochemical energy storage system as a consequence of the expansion of technological advancement and the electrical vehicle sector. Manganese sulphide (MnS) nanoflakes were produced by hydrothermal technique at various heating temperatures (100,110,120, and 130 oC). The existence of MnS is revealed by the X-ray diffraction (XRD) diffractogram, and α- and γ-MnS crystals were effectively grown on a nickel (Ni) foam. MnS nanoflakes were seen under field-emission scanning electron microscope (FESEM). The crystalline structure of MnS nanoflakes is susceptible to the variation depending on the heating temperature, and at 120 oC MnS produced nanoflake with additional wrinkles. Through Brunauer–Emmett–Teller(BET) analysis, the thermal and physical adsorption investigations demonstrated the high total surface area and thermal stability of MnS electrodes. The findings of BET studies demonstrate that MnS-120 has the highest surface BET (SBET) and the smallest pore size distribution (PSD),which later increases the total surface area of MnS nanoflakes for an effective energy storage mechanism. MnS is structurally stable below 200 oC, according to thermogravimetric analysis (TGA). MnS-120 electrode has a maximum specific capacity of 1003.5 C/g at 5 A/g and a 49% rate capability. Supercapattery devices were created in a MnS-120//activated carbon (AC) configuration to assess the real-time performance of the material. The MnS-120//AC demonstrated better efficiency by offering specific energy of 69.24 Wh/kg at 2953 W/kg. The life cycle test confirmed that MnS-120//AC is stable with a capacity retention of value of 96% after 4000 cycles.
Urban Resilience of Metropolitans in the Mid-Latitude Coastal Regions of East Asia for Global Weather Anomalies
Authors: Song Youngbae , Song Jaeyi 
Published: August 2023

Abstract
Weather patterns in cities located in both the eastern and western coastal regions of the Pacific may tend to change coupled with global weather anomalies. This study analyzes temperature variabilities in the western coastal region of the Pacific associated with LST, NDVI, and ONI over the past 57 years. The results indicate that the temperature rise was 0.34°C, significantly higher than global warming of 0.15 to 0.20°C per decade. El Niño/La Niña events typically reach the East Asian coastal regions 4 to 6 months after their occurrence, and their impact seems more severe in the following year. El Niño influenced the formation of high temperatures and remained high even after neutralization. La Niña led to significant temperature drops and extended cold waves; this climate phenomenon greatly differs from the typical region-specific climate over a long period. Spatiotemporal distributions of LST revealed that weather anomalies significantly influenced urban greenery and forests, which suffered from physiological stresses, compromising their ability to provide ecosystem services that protect against climate change or mitigate their impacts. NDVI-Mass values increased with rising temperatures caused by El Niño but decreased drastically with low vegetation vitality at low temperatures caused by La Niña. Urban greenery and forests recover after absorbing the impact of global weather anomalies but experience a short-term loss of 5% and an average long-term loss of approximately 1% in NDVI-Mass yearly. This continuous loss indicates a lack of equilibrium from 1985 to the present. Regional warming in the study area has continued to rise.
Association of chronic morbidity and early retirement in India: Evidence from Longitudinal Ageing Study in India
Authors: Akhtar Shamrin , Mohanty Sanjay K 
Published: August 2023

Abstract
Context:
Chronic diseases have a profound impact on productivity and job interest, often resulting in significant losses in both. Numerous scientific research has shown that chronic illnesses have a negative impact on work-related outcomes. The findings of these studies highlight the importance of studying the association of chronic morbidity and early retirement by addressing chronic diseases comprehensively in the workplace to promote employee well-being, productivity, and overall work satisfaction.
Methods
The initial phase of the Longitudinal Ageing Study in India (LASI) was utilized, focusing on outcome variables related to early retirement caused by poor health. Through multivariate analysis using a probit regression model, we evaluated the correlation between early retirement and specific chronic diseases, as well as the cumulative number of chronic diseases and other sociodemographic factors.
Findings:
Neurological problems and stroke were those showing the strongest association with early retirement, followed by chronic lung and heart diseases. Among other covariates, the risk of retirement was significantly lower among the currently married and rural sector. Considering socioeconomic characteristics, subjects with lower education were significantly at higher risk of early retirement.
Conclusions
We observed a statistically significant connection between chronic health conditions and early retirement among individuals nearing the age for receiving statutory pensions, even after accounting for potential confounding factors. The association between health issues and early retirement was particularly pronounced among subjects affected by stroke and neurological problems. The study results highlight the importance of developing interventions aimed at enhancing prevention and treatment of chronic illnesses, as well as creating workplace accommodations for individuals with health issues, in order to bolster labor force participation rates among older workers
Phylogeographic evolution of horseshoe bat sarbecoviruses in Vietnam and implications for the origins of SARS-CoV and SARS-CoV-2
Authors: HASSANIN Alexandre , Tu Vuong , Görföl Tamás , Ngon Lam , Pham Phu , Hang Chu , Tuan Tran , Prot Matthieu , SIMON-LORIERE Etienne , Kemenesi Gabor , Toth Gabor , Moulin Laurent , Wurtzer Sébastien 
Published: August 2023

Abstract
Previous studies on horseshoe bats (Rhinolophus spp.) have described many coronaviruses related to SARS-CoV (SARSCoVr) in China and only a few coronaviruses related to SARS-CoV-2 (SARSCoV2r) in Yunnan, Cambodia, Laos and Thailand. Here, we report the results of several field missions carried out in 2017, 2021 and 2022 across Vietnam during which 1,218 horseshoe bats were sampled. We assemble 38 Sarbecovirus genomes: 26 SARSCoVr from R. thomasi; six SARSCoVr and four SARSCoV2r from R. affinis; and two recombinants of SARSCoVr and SARSCoV2r from R. pusillus, one showing a receptor-binding domain of the Spike protein very similar to SARS-CoV-2. We detected a bat co-infected with four coronaviruses, including two sarbecoviruses. Our phylogeographic analysis suggests a divergent evolution between sarbecoviruses from subtropical northern Vietnam and those from tropical southern Vietnam, emergence of SARS-CoV in horseshoe bats from northern Yunnan and emergence of SARS-CoV-2 in horseshoe bats from southern Yunnan.
Site Formation Process Studies as Aircraft Site Identification: A WWII-era Flying Boat Case Study
Authors: Pruitt James , McKinnon Jennifer F 
Published: August 2023

Abstract

Compared to the study of shipwrecks, the investigation of submerged aircraft is relatively recent in underwater archaeology. With the passing of time and the addition of World War II (WWII) sites to historical registers, the inclusion of aircraft in the Sunken Military Craft Act of 2004, and the continued expansion of the Defense POW/MIA Accounting Agency’s (DPAA) mission to recover lost pilots and crew, these studies have become increasingly important to a variety of stakeholders. Site formation process (SFP) studies stipulate that a crucial aspect of the accurate investigation and interpretation of a site first requires a thorough understanding of the processes that created and subsequently altered the site. For terrestrial archaeologists, as well as maritime archaeologists studying shipwreck sites, a well-established database of such knowledge already exists. For submerged aircraft, however, this database is small, yet growing. This paper will contribute to the understanding and interpretation of submerged aircraft sites through the study of the processes that created and subsequently affected a submerged WWII-era PB2Y Coronado aircraft located in Tanapag Lagoon, Saipan, Commonwealth of the Northern Mariana Islands (CNMI). Archaeological and historical evidence is examined through the lens of SFP studies to identify the specific aircraft, determine its cause of crash, and understand cultural and natural factors that have impacted the site and may affect it today.
Clinical significance of tumor suppressor genes methylation in circulating tumor DNA of patients with pancreatic cancer
Authors: Xin WanPeng , Tu Shuju , Yi SiQing , Xiong Yuanpeng , Fang Kang , Sun Gen , Xiao Weidong 
Published: August 2023

Abstract
Background
Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic and prognostic biomarker in various tumors. However, the role of tumor suppressor genes (TSGs) methylation in ctDNA of patients with pancreatic cancer (PC) remains largely unclear.
Methods
Patients with PC (n = 43), pancreatic benign diseases (n = 39), and healthy controls (n = 20) were enrolled in the study. Quantitative analysis of methylation pattern of five candidate TSGs including NPTX2, RASSF1A, EYA2, p16, and ppENK in ctDNA was performed by next generation sequencing (NGS). The diagnostic performances of these 5-TSGs methylation were assessed by the operating characteristic (ROC) curve and clinicopathological features correlation analysis. Meanwhile, the changes in methylation levels of these 5-TSGs on the 7th postoperative day were evaluated in 23 PC patients who underwent radical resection.
Results
The methylation levels of RASSF1A, EYA2, ppENK and p16 genes in patients with PC were significantly higher than those in healthy controls. EYA2, p16 and ppENK genes showed significantly hypermethylation in PC than those in pancreatic benign diseases. NPTX2, RASSF1A, EYA2, p16 and ppENK genes showed significantly hypermethylation in pancreatic benign diseases than those in healthy controls (P < 0.05). The methylation levels of these 5 candidate TSGs were not correlated with the tumor size, nerve invasion, lymph node metastasis and TNM stage of PC. The AUC of these biomarkers for diagnosis of PC ranged from 0.65 to 0.96. The AUC values of these methylated genes and CpG sites for differentiating malignant and benign pancreatic diseases were ranging from 0.68 to 0.92. Combined the hypermethylated genes improved the detective ability of PC than single gene. The methylation levels of NPTX2, EYA2 and ppENK genes were significantly decreased after radical resection of PC.
Conclusion
Quantitative analysis of methylation pattern of NPTX2, RASSF1A, EYA2, p16 and ppENK in ctDNA by NGS could be a valuable non-invasive tool for detection and monitoring of PC.
Analyzing the Reporting Error of Public Transport Trips in the Danish National Travel Survey Using Smart Card Data
Authors: Sfeir Georges , Rodrigues Filipe , Zeid Maya Abou , Pereira Francisco Camara 
Published: August 2023

Abstract

Household travel surveys have been used for decades to collect individuals and households’ travel behavior. However, self-reported surveys are subject to recall bias, as respondents might struggle to recall and report their activities accurately. This study addresses examines the time reporting error of public transit users in a nationwide household travel survey by matching, at the individual level, five consecutive years of data from two sources, namely the Danish National Travel Survey (TU) and the Danish Smart Card system (Rejsekort). Survey respondents are matched with travel cards from the Rejsekort data solely based on the respondents’ declared spatiotemporal travel behavior. Approximately, 70% of the respondents were successfully matched with Rejsekort travel cards. The findings reveal a median time reporting error of 11.34 minutes, with an Interquartile Range of 28.14 minutes. Furthermore, a statistical analysis was performed to explore the relationships between the survey respondents’ reporting error and their socio-economic and demographic characteristics. The results indicate that females and respondents with a fixed schedule are in general more accurate than males and respondents with a flexible schedule in reporting their times of travel. Moreover, trips reported during weekdays or via the internet displayed higher accuracies compared to trips reported during weekends and holidays or via telephones. This disaggregated analysis provides valuable insights that could help in improving the design and analysis of travel surveys, as well accounting for reporting errors/biases in travel survey-based applications. Furthermore, it offers valuable insights underlying the psychology of travel recall by survey respondents.
Seaweed Extracts as a Promising Natural Source Exert a Therapeutic Approach via Inducing Cytotoxicity and Apoptosis in Chronic Myeloid Leukemia Cell Model
Authors: KOZAK-BALKAN Aysegul , ALCITEPE Ilayda , UYSAL Selahattin Alperen , KURUOGLU Busra Nur , BAYKAN Sura , TEZCANLI-KAYMAZ Burcin , TUNEY Inci 
Published: August 2023

Abstract
Seaweeds are considered an essential source of metabolites and molecules in novel drug research. The existence of antimicrobial, antimutagenic, antioxidant, anti-cancer etc., effects of active compounds has been proven. Cancer, characterized by changes in the expression of multiple genes, is a widespread disease leading to death worldwide. To contribute to the novel drug discovery research, we aimed to determine the anti-cancer activities of 10 macroalgae by performing cytotoxicity, apoptosis, and total antioxidant and gene expression analysis of selected macroalgae species. IC50 values ​​of the extracts of selected algae species were determined by Water-Soluble Tetrazolium (WST) analysis. Hexane extract of D. dichotoma var. intricate, methanol extract of A. nayadiformis, and methanol extract of the green algae U. lactuca showed the best cytotoxic activities. Also, the dichloromethane extract of D. dichotoma var. intricate showed the best apoptotic effect by inhibiting 77.4% of the cells in apoptosis analyses on the K562 cell line. According to the total antioxidant analysis results, the C. circinatum showed the best antioxidant activity in hexane extracts with 165.11% inhibition; P. pavonica species showed the lowest DPPH radical scavenging activity with 6.22% inhibition. D. dichotoma var. intricate extracts showed promising anti-cancer activity among others. Finally, the revealed selected target genes' expression profile indicated that regulation was observed, especially in the JAK-STAT pathway forthcoming actors with induced pro-apoptotic genes and downregulated oncogenes. These results point out that the algae extracts could be promising agents for CML therapy either as mono or combined treatments.
β-asarone inhibits autophagic neuron death by downregulating reactive astrocytes-derived SPARC expression in LPS-induced SH-SY5Y cells
Authors: Yu Hongxia , Wang Sichen , Huang Qiaoyan , Wu Sichen , Tan Xiaoyao , Li Xinyue , Xu Yueling , Guo Shunyuan , Ji Liting , Li Changyu 
Published: August 2023

Abstractβ-asarone, the main active component ofAcori tatarinowiirhizoma (ATR), exhibits several pharmacological properties, including anti-inflammatory, anti-aging, and neuroprotective effects. In recent years, a large number of studies have shown that β-asarone exerts a positive effect on improving the cognitive level of individuals with Alzheimer’s disease (AD). However, the effects of β-asarone on autophagy in neuroinflammation-induced AD and the potential underlying mechanisms remain unclear. In the present study, we found that β-asarone inhibited LPS-induced activation of NHA cells and significantly decreased the expression of inflammatory factors andsparc. Exposure to exogenous SPARC promoted apoptosis and autophagy in neuronal cells. Further, we co-cultured LPS-induced reactive human astrocytes [NHA (normal human astrocytes)] with human neuronal cells (SH-SY5Y cell line) to establish a neurocyte inflammatory microenvironment to mimic the neuroinflammatory model of ADin vitro. Based on the above co-culture system, we observed that after SPARC overexpression in NHA, the behavior of the neuronal cells resembled that after exogenous SPARC treatment. However, β-asarone treatment reversed these effects and protected the cells against neuronal damage. These findings suggested that the matrix protein SPARC plays an important role in neuronal damage in AD model mice, and β-asarone intervention can be utilized as a potential therapeutic strategy for AD.
Monotonicity of solutions for fractional parabolic equations
Authors: Liu Gemei 
Published: August 2023

Abstract
In this paper, we consider the following fractional parabolic equation with a gradient nonlinear term on the upper half space
\begin{equation*}
\begin{cases}
\frac{\partial u}{\partial t}(x, t)+(-\Delta)^s u(x, t)=f(t,x,u(x,t),\triangledown u(x,t)),& (x, t) \in \mathbb{R}_+^{n} \times \mathbb{R}, \\u(x, t) = 0,& (x, t) \notin \mathbb{R}_+^{n} \times \mathbb{R}.
\end{cases}
\end{equation*}
Without assuming any asymptotic decay of $u$ near infinity, we prove that~$u(x,t)$~is strictly increasing with respect to $x_1$ by the method of moving planes. Meanwhile, we show the existence of positive solutions related to the fractional parabolic equations on the whole space $\mathbb{R}^{n-1}.$
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures
Authors: Rashidi Ahmad , Tran Diana , Peelen Caithlin , Gent Michiel van , Ouwendijk Werner , Verjans Georges 
Published: August 2023

Abstract
Background Herpes simplex virus (HSV) encephalitis (HSE) is a serious and potentially life-threatening disease, affecting both adults and newborns. Progress in understanding the virus and host factors involved in neonatal HSE has been hampered by the limitations of current brain models that do not fully recapitulate the tissue structure and cell composition of the developing human brain in health and disease. Here, we developed a human fetal organotypic brain slice culture (hfOBSC) and determined its value in mimicking the neuropathology of HSE in vitro .Methods Cell viability and tissues integrity were determined by lactate dehydrogenase release in supernatant and detailed immunohistological (IHC) analyses. Brain slices were infected with green fluorescent protein (GFP-) expressing HSV-1 and HSV-2. Virus replication and spread were determined by confocal microscopy, PCR and virus culture. Cell tropism and HSV-induced neuropathology was determined by IHC analysis. Finally, the in situ data of HSV-infected hfOBSC were compared to the neuropathology detected in human HSE brain sections.Results Slicing and serum-free culture conditions were optimized to maintain the viability and tissue architecture of ex vivo human fetal brain slices for at least 14 days at 37oC in a CO2 incubator. The hfOBSC supported productive HSV-1 and HSV-2 infection, involving predominantly infection of neurons and astrocytes. Both viruses induced programmed cell death – especially necroptosis – in infected brain slices at later time points after infection. The virus spread, cell tropism and role of programmed cell death in HSV-induced cell death closely mimicked the neuropathology of HSE.Conclusions We developed a novel human brain model in which the viability of the major brain-resident cells – including neurons, microglia, astrocytes and oligodendrocytes – and the tissue architecture is maintained for at least 2 weeks in vitro under serum-free conditions. The close resemblance of cell tropism, spread and neurovirulence of HSV-1 and HSV-2 in the hfOBSC model with the neuropathological features of human HSE cases underscores its potential to detail the pathophysiology of other neurotropic viruses and as preclinical model to test novel therapeutic interventions.