bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular interpretation of X(3960) as $$D_s^+ D_s^-$$ state
Authors: Mutuk Halil 
Published: December 2022

AbstractWe study$$D_s^+ D_s^-$$Ds+Ds-and$$D \bar{D}$$DD¯states assuming that they are hadronic molecules with$$J^{PC}=0^{++}$$JPC=0++quantum number. We use two-point QCD sum rule formalism and extract the mass and decay constant values of these states. We take into account contributions of various quark, gluon, and mixed vacuum condensates up to dimension eight. The extracted mass and decay constant values of$$D \bar{D}$$DD¯and$$D_s^+ D_s^-$$Ds+Ds-states read as$$M_{D \bar{D}} = 3795^{+85}_{-82}~{\textrm{MeV}} $$MDD¯=3795-82+85MeV,$$f_{D \bar{D}} = 1.70^{+0.33}_{-0.29} \times 10^{-2} ~{\textrm{GeV}}^5$$fDD¯=1.70-0.29+0.33×10-2GeV5, and$$M_{D_s^+ D_s^-} = 3983^{+93}_{-88} ~{\textrm{MeV}}$$MDs+Ds-=3983-88+93MeV,$$f_{D_s^+ D_s^-} = 2.52^{+0.64}_{-0.54} \times 10^{-2} ~{\textrm{GeV}}^5$$fDs+Ds-=2.52-0.54+0.64×10-2GeV5, respectively. The predicted mass of$$D_s^+ D_s^-$$Ds+Ds-state is in good agreement with the recent LHCb observation and supports quantum number and molecular picture assignments. A possible observation of$$D \bar{D}$$DD¯state would help for establishing the lowest four-quark state in charmonium sector.
Prolonged Survival Following Intra-abdominal Mycobacterium abscessus Infection Without Antimicrobial Therapy or Surgical Intervention
Authors: Tiwari Ankur , Geringer Matthew R. , Barsoumian Alice , Masella Pamela , Vreeland Timothy J. , Clifton Guy T. 
Published: December 2022

Management of Mycobacterium abscessus infection involves prolonged multidrug antibiotic therapy with surgical resection indicated in extensive disease and abscesses. We report a case of post-surgical intra-abdominal M. abscessus infection with prolonged survival and radiographic resolution without intervention. A 51-year-old female who had a prolonged hospital stay with multiple surgeries following a complicated laparoscopic sleeve gastrectomy developed multiple M. abscessus intra-abdominal and abdominal wall abscesses with cutaneous fistulae. She was started on a multidrug antibiotic regimen. However, the patient terminated the regimen after 4 weeks due to intolerable side effects and was transitioned to hospice care. She showed steady clinical improvement with radiographic resolution of the abscesses over the next year. In the context of the limited understanding of these infections, our finding is notable, given that in this period, she avoided potential hospitalizations, life altering side effects of prolonged antimicrobial therapy, and complications from more surgeries.
Visible Apical Blebs on CXR: Are Plain Radiographs Under-Utilized in Primary Spontaneous Pneumothorax?
Authors: Lotakis Dimitra M. , Bailey Keoni , Criss Cory , Speck K. Elizabeth 
Published: December 2022

A primary spontaneous pneumothorax (PSP) is caused by rupture of subpleural emphysematous blebs, without inciting event or pre-existing co-morbidity. A previously healthy 16-year-old male presented with upper chest pain. As expected, chest radiographs (CXR) demonstrated a 13 mm pneumothorax. Additionally, a 4.7 cm apical bleb was identified. After six-hours of observation and non-rebreather oxygen mask therapy, follow-up CXR confirmed stable findings. The patient was subsequently discharged home after symptoms improved. Follow-up CXR at 2-weeks confirmed persistent visible apical bleb. After lengthy discussion addressing patient and parental concerns, elective surgical management was pursued. Current literature suggests blebs are not routinely identified on CXR. While there is no universally accepted management algorithm for PSP in children, visible apical blebs on CXR may influence the decision to pursue surgical intervention. Shared decision making should involve counseling regarding the recurrence risk following surgery, and consideration of patient-specific factors including patient and parental anxiety.
Assessment of Outcomes in Laparotomy vs Laparoscopy: A Propensity Score Matched Analysis of Patients Sustaining Single Penetrating Left Upper Quadrant Injury
Authors: Elkbuli Adel , Andrade Ryan , Ngatuvai Micah , Khan Areeba , Liu Huazhi , Bilski Tracy , Ang Darwin 
Published: December 2022

Background We aim to compare outcomes between laparotomy and laparoscopy in trauma patients with single penetrating left upper quadrant injuries. Methods Using a 1:1 propensity score match, a retrospective study was conducted utilizing data from the ACS-TQP-PUF between 2016 and 2019. Adults sustaining a single penetrating left upper quadrant injury who received either a laparotomy or laparoscopy were included for analysis. The primary outcome was inpatient mortality. Secondary outcomes included ICU-LOS, H-LOS, and complication rates. Multivariable regression and reliability adjustments were performed to control for confounding. Results 486 patients receiving laparotomy were matched to 486 patients receiving laparoscopy. No differences in inpatient mortality (1.2% vs 2.9%, aOR: 2.92, 95% CI: .32, 26.31); however, patients undergoing laparotomy experienced higher complication rates (7.0% vs 1.2%, aOR: 9.61, 95% CI: 1.94, 47.48), pRBC transfusions (21.8% vs 6.4%, aOR: 3.19, 95% CI: 1.66, 6.13), and H-LOS (Mean ± SD: 8.1 ± 9.8 vs 3.9 ± 4.0, P = .0002). Lower ISS (1 - 15) undergoing laparotomy had more complications (4.3% vs .7%, aOR: 13.52, 95% CI: 1.39, 131.69), pRBC transfusions (13.9% vs 4.9%, aOR: 3.21, 95% CI: 1.53, 6.75), and H-LOS (Mean ± SD: 6.7 ± 7.1 vs 3.6 ± 3.2, P < .0001). There were no differences in mortality among patients with a lower ISS (1.5% vs .4%, aOR: 77.2, 95% CI: (<.001, >999). Conclusions Laparotomy is associated with increased rates of complications for single penetrating LUQ trauma. For patients with low ISS, laparoscopy is associated with better outcomes without increase in mortality.
Sustaining innovation during downsizing strategy through knowledge coupling, business process digitization, and market capitalizing agility
Authors: Fawad Sharif Sayed Muhammad , Yang Naiding , Rehman Atiq ur , Alghamdi Omar 
Published: December 2022

COVID-19 has developed chaos and uncertainty for small and medium enterprises (SMEs) causing mass downsizing. Under such uncertainty, innovation is key to survival and agility to growth. This study examines role of knowledge coupling and business process digitization (BPD) in sustaining innovation through market capitalizing agility (MCA) besides downsizing strategy. Data have been collected from top and mid management of Chinese manufacturing SMEs and analyzed with knowledge-based view and self-tuning model through Smart-PLS 4. Knowledge coupling positively contributes to MCA and innovation irrespective of downsizing strategy. Effect of BPD on innovation performance is same; however, insignificant on MCA in no-downsizing sample. Likewise, MCA positively influences innovation performance and positively mediates between knowledge coupling (BPD) and innovation performance only during downsizing. This study is first of its kind to establish mediating effect of MCA between knowledge coupling (BPD) and innovation performance during downsizing phase and offers significant theoretical and practical implications. JEL Classification: J63, O31
Procalcitonin as prognostic factor in patients with Fournier’s gangrene
Authors: Ongaro Luca , Claps Francesco , Rizzo Michele , Di Cosmo Giacomo , Traunero Fabio , D’Andrea Eugenia , Garaffa Giulio , Cai Tommaso , Zucchi Alessandro , Trombetta Carlo , Liguori Giovanni 
Published: December 2022

Introduction: Fournier’s Gangrene (FG) has still a mortality rate up to 45%. Several studies identified prognostic factors but there is a knowledge gap concerning procalcitonin (PCT) levels and mortality risk in FG. This study is aimed to assess the role of PCT as prognostic factor in FG. Materials and methods: The medical records of 20 male FG patients admitted at the Department of Urology of “Cattinara” Hospital, University of Trieste between January 2019 and November 2020 were retrospectively reviewed. Clinical, demographic, microbiological data were collected. The Fournier’s Gangrene Severity Index (FGSI) was calculated for each patient. Results: Thirteen (65%) of 20 patients survived. Median age was 58 years (IQR 51–88), 15 patients (75%) had a Charlson Comorbidity Index (CCI) score ⩾2, 1 (5%) equal to 0, 4 to 1 (20%). Median FGSI score was 6 (IQR 2–12) and median PCT 0.8 ng/ml (IQR 0.04–2.12). At multivariate analysis PCT levels >0.05 ng/ml were associated with an increased overall mortality risk (OR 2.14, CI 1.25–4.27, p = 0.002). CCI score ⩾2 (OR 1.51, CI 1.01–2.59, p = 0.04), Streptococcical etiology (OR 3.41, CI 2.49–4.61, p = 0.002) and FGSI score >9 (OR 1.41, CI 1.19–2.21, p = 0.004) were associated with unfavorable outcome. Conclusion: PCT might be a prognostic factor in FG. CCI and FGSI are useful tools in mortality risk stratification. Streptococcical etiology is associated with unfavorable outcome. Further larger clinical trials are pending.
Effects of Multicomponent Injury Prevention Programs on Children and Adolescents’ Fundamental Movement Skills: A Systematic Review With Meta-Analyses
Authors: Jimenez-Garcia John A. , Miller Matthew B. , DeMont Richard G. 
Published: December 2022

Objective Fundamental movement skills (FMS) are essential to participate in physical activity. Understanding the effects of multicomponent injury prevention programs (MIPP) on FMS may help promote safe physical activity. Our objective was to synthesize the evidence on the effects of MIPP on biomechanical outcomes and neuromuscular performance measured on children and adolescents while performing FMS. Data Source We searched PubMed, SPORTDiscus, Web of Science, and SCOPUS. Study Inclusion and Exclusion Criteria We included peer-reviewed randomized controlled trials, published in English, that analyzed the effects of MIPP on biomechanics and neuromuscular performance of FMS in participants under 18 years of age. Data Extraction Two reviewers screened the articles, assessed the quality of the evidence using the Physiotherapy Evidence Database (PEDro) scale, and synthesized the data. Data Synthesis We conducted meta-analyses and reported the characteristics, outcomes, and risk of bias of studies. Results We included 27 articles that reported data from 1,427 participants. Positive effects on FMS were reported in 23 of the 27 included articles. Vertical Jump, running speed, acceleration, and dynamic balance presented positive-significant pooled effect sizes. Dribbling and horizontal jump presented non-significant pooled effect sizes. Conclusion MIPP can positively affect FMS in children and adolescents in sports-related settings. Lack of participant compliance and implementation fidelity may affect MIPP effectiveness. Including MIPP in physical literacy interventions, physical education classes, and organized physical activity may lead to functional adaptations that help promote safe physical activity.
Short term clinical outcomes of a Prochondrix® thin laser-etched osteochondral allograft for the treatment of articular cartilage defects in the knee
Authors: Mehta Vishal M , Mehta Shaan , Santoro Steven , Shriver Ryan , Mandala Cassie , Weess Cameron 
Published: December 2022

Objective: The purpose of this study is to evaluate the short-term clinical outcomes of Prochondrix® novel thin, laser-etched osteochondral allograft on isolated articular cartilage defects. Methods: Eighteen patients with isolated, symptomatic, full-thickness articular cartilage lesions were treated with marrow stimulation followed by placement of a T-LE allograft. Demographic and intra-operative data was recorded as well as pre- and post-operative International Knee Documentation Committee (IKDC), Short Form-36 (SF-36), Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS) and Tegner scores. Pre- and post-operative data was compared at 6, 12, 24 and 36 months post operatively. Failures requiring reoperation were also recorded. Results: At a mean follow-up of 2.5 years (6–43 months), VAS decreased from 6.55 to 2.55 ( p = .02) and subjective IKDC scores increased from 37.61 to 59.65 ( p = .02). Statistically significant increases were also seen in KOOS Function-Sports and Recreational Activities (+26.04, p = .04) and KOOS QOL (+18.76, p = .007) as well as in SF-36 Physical Functioning (+25.20, p = .04), Energy/Fatigue (+16.50, p = .02), Social Functioning (+11.79, p = .04), and Bodily Pain (+25.18, p = .04). There were two failures requiring reoperation: one conversion to a patellofemoral arthroplasty (PFA), and one graft dislodgement which required removal. Conclusion: Treatment of articular cartilage lesions of the knee with ProChondrix® has demonstrated sustained positive results out to a mean follow-up of two and a half years in this prospective case series with a low failure rate that required reoperation (2 patients) in this series. These results are comparable to the short-term results of other cartilage restoration procedures currently in use today. A meta-analysis of osteochondral allografting demonstrated a mean 86.7% survival rate at 5 years with significant improvements in clinical outcome scores reaching MCID values.
Med Sim Studio: An Open-Access Simulation Platform for Running and Sharing Dynamic Display of Patient Data in Package Scenarios
Authors: Blumenberg Adam , Kessler David 
Published: December 2022

Background/Objectives Specialized software may augment in-situ simulation, remote learning, oral boards preparation, and personalized remediation through simulation. Simulation educators often lack access to simulation software that meets their needs because existing software packages are cost prohibitive, have design gaps, or are not user friendly. Additionally, educators require the ability to easily author their own customized cases and share them with colleagues via an integrated software platform. Methods A needs assessment was performed by interviewing simulation educators, residents, medical students, and residency assistant program directors. Based on this, the software platform Med Sim Studio was developed to include vital sign monitoring, hundreds of high-resolution medical images, a video ultrasound library, documentation, evaluation tools, packaged cases reflecting the core EM curriculum, case authoring and sharing ability, and an easy-to-use interface. Over the course of a year and a half, the software was programmed using C++ on Microsoft Visual Studio. Users can author cases which are stored as JSON data objects and can be shared via email, portable media, or retrieved through a central MySQL database. Discussion Med Sim Studio joins other free software resources for simulation with the addition of unique features including immediate access to a comprehensive suite of medical visual stimuli, automated documentation and data collection, cases pre-loaded with the relevant background information and images, and the ability to customize and share cases instantly. Med Sim Studio allows educators to propagate their own scholarship through case sharing functionality. These can be transferred online (via the embedded database functionality or through email attachments), or via portable media (such as USB drive or optical disk). The case-sharing aspect of Med Sim Studio simplifies the process for simulation educators to contribute novel cases and promote the community of medical education.
The Adolescent Concept of Social Participation—A Qualitative Study on the Concept of Social Participation from Adolescents with and without Physical Disabilities
Authors: Bärwalde Tim , Hoffmann Laura , Fink Astrid , Völlm Carina , Martin Olaf , Bernard Marie , Gebhard Britta , Richter Matthias 
Published: December 2022

Purpose The construct of social participation is still not clearly defined. To reach a better understanding of social participation, the perspectives of adolescents must be taken into account. This study explores the adolescent concept of social participation and expands knowledge of the meaning of subjective components of the term. Methods Thirty-four semi-structured interviews were conducted with adolescents with and without physical disabilities or chronic diseases between the ages of 12 and 17 and analyzed according to grounded theory. Results Adolescents describe social participation as involving reflexive interaction with their social environment. Furthermore, forming a social environment plays an important role. All components of the concept are embedded in a context that influences the ways adolescents participate. Adolescents differentiate between active and passive forms of social participation. The concept of reflexive interaction is situated within an interdependent structure of components such as the “feeling of belonging” and the feeling of “well-being” among adolescents. Conclusion The results expand the current state of knowledge regarding the theoretical differentiation of social participation by exploring subjective components of the term. This offers the possibility of supplementing the theoretical frameworks of social participation and supports the understanding of the critical importance of social participation for adolescents.
Semi-Lagrangian 4d, 5d, and 6d kinetic plasma simulation on large-scale GPU-equipped supercomputers
Authors: Einkemmer Lukas , Moriggl Alexander 
Published: December 2022

Running kinetic plasma physics simulations using grid-based solvers is very demanding both in terms of memory as well as computational cost. This is primarily due to the up to six-dimensional phase space and the associated unfavorable scaling of the computational cost as a function of grid spacing (often termed the curse of dimensionality). In this article, we present 4d, 5d, and 6d simulations of the Vlasov–Poisson equation with a split-step semi-Lagrangian discontinuous Galerkin scheme on graphic processing units (GPUs). The local communication pattern of this method allows an efficient implementation on large-scale GPU-based systems and emphasizes the importance of considering algorithmic and high-performance computing aspects in unison. We demonstrate a single node performance above 2 TB/s effective memory bandwidth (on a node with four A100 GPUs) and show excellent scaling (parallel efficiency between 30% and 67%) for up to 1536 A100 GPUs on JUWELS Booster.
A feasible and safe standardized protocol for ultrasound and intracavitary electrocardiogram-based tip navigation and tip location during placement of peripherally inserted central catheters
Authors: Liu Bing , Liu Yan , Li Jiaqian , Kang Junren , Sun Wenyan 
Published: December 2022

Background: Peripherally inserted central catheters (PICCs) are performed for medium and long term intravenous therapy. The most recent guidelines recommend the use of ultrasound-guided venipuncture to reduce surgery-related complications. In recent years, bedside ultrasound has also been used as evidence of accuracy in tip navigation and tip positioning. This paper is aimed to investigate using tip navigation with the ultrasonic technique and intracavitary electrocardiogram during the catheterization, and to suggest a feasible and safe standardized protocol for clinical practice. Methods: A total of 1727 tumor clients who suffered from combined the ultrasonic technique with intracavitary electrocardiogram (ECG + US group) to confirm the tip location of PICC were included in Peking Union Medical College Hospital in 2020. And based on electronic medical records according to the types of cancer as 1:1 to select 1727 cases who only underwent electrocardiogram (ECG group) to verify the tip location of catheters with the same team in 2019. Compared two groups of purpose of catheter, insertion site of upper limbs, times of puncture and delivery catheters, tip location and malposition of peripherally inserted central catheter, and analysis of the safety and feasibility. Results: There were no significant differences between the two groups in the purpose of catheter, insertion site of upper limbs, times of puncture, and delivery catheters. The percentage of optimal tip location in ECG + US group was significantly higher than that in ECG group, and the rate of malposition of catheters was obviously lower than that in ECG group ( p < 0.001). Conclusions: Tip navigation based with ultrasound and intracavitary electrocardiogram has high accuracy to confirm tip location of PICC, and it is also feasible and safe, which can not only to make up for the deficiency of patients without surface P waves who could not be applied ECG but also to fit for all patients.
Plasma tumor mutation burden is associated with clinical benefit in patients with non-small cell lung cancer treated with anti-programmed death-1 monotherapy
Authors: Lee Jii Bum , Park Hyung Soon , Choi Su Jin , Heo Seong Gu , An Ho Jung , Kim Hye Ryun , Hong Min Hee , Lim Sun Min , Chang Kyle , Quinn Katie , Odegaard Justin , Shim Byoung Yong , Cho Byoung Chul 
Published: December 2022

Background: The clinical utility of plasma tumor mutational burden (pTMB) requires further validation. Herein, the pTMB and genetic alterations were investigated as predictive biomarkers for anti-PD-1 monotherapy outcome in metastatic non-small cell lung cancer (NSCLC). Methods: The GuardantOMNI panel (Guardant Health) was used to identify pTMB and genetic alterations. Data from 99 patients with metastatic NSCLC treated with pembrolizumab or nivolumab in first-, second-, or third-line settings between June 2016 and December 2020 were collected. Associations between pTMB and clinical benefit rate (CBR, stable disease ⩾6 months or partial response), progression-free survival (PFS), and overall survival (OS) were assessed. Results: Median pTMB in 84 patients was 10.8 mutations/megabase (mut/Mb). Histological analyses revealed that 61 and 36% of the patients had adenocarcinomas and squamous NSCLC, respectively. Most patients were treated with nivolumab (74%) and most anti-PD-1 agents were administered as second-line treatment (70%). The median follow-up duration was of 10.9 months (range, 0.2–40.7). Patients with high pTMB (⩾19 mut/Mb) had a higher CBR (69%) compared with low pTMB patients (33%; p = 0.01). ARID1A ( p = 0.007) and either ERBB2 or KIT mutations ( p = 0.012) were positive and negative determinants, respectively, for clinical benefit. Multivariate analysis further showed that high pTMB was an independent predictive biomarker for both PFS [hazard ratio (HR) = 0.44, 95% confidence interval (CI): 0.22–0.88, p = 0.02] and OS (HR = 0.37, 95% CI: 0.18–0.76, p = 0.007). Conclusion: High pTMB (⩾19 mut/Mb) is significantly associated with CBR in patients with NSCLC treated with anti-PD-1 agents.