bluuebunny/crossref_metadata_2025_split huggingface dataset:
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
Authors: Tran Trung The , Vaage Eline Benno , Mehta Adi , Chopra Adity , Tietze Lisa , Kolderup Anette , Anthi Aina , König Marton , Nygaard Gro , Lind Andreas , Müller Fredrik , Nissen-Meyer Lise Sofie , Magnus Per , Trogstad Lill , Mjaaland Siri , Søraas Arne , Midtvedt Karsten , Åsberg Anders , Barratt-Due Andreas , Medhus Asle W. , Høivik Marte Lie , Lundin Knut , Karlsen Randi Fuglaas , Dahle Reidun , Danielsson Karin , Thomassen Kristine Stien , Kro Grete Birkeland , Cox Rebecca J. , Zhou Fan , Langeland Nina , Aukrust Pål , Melum Espen , Åvitsland Tone Lise , Wiencke Kristine , Holter Jan Cato , Munthe Ludvig A. , Grødeland Gunnveig , Andersen Jan-Terje , Vaage John Torgils , Lund-Johansen Fridtjof 
Published: December 2022

AbstractDiagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels of antibodies to the receptor-binding domain of ancestral SARS-CoV-2 (RBDwt). However, the predictive value for protection against new variants of concern (VOCs) has not been firmly established. Here, we used bead-based arrays and flow cytometry to measure binding of antibodies to spike proteins and receptor-binding domains (RBDs) from VOCs in 12,000 serum samples. Effects of sera on RBD-ACE2 interactions were measured as a proxy for neutralizing antibodies. The samples were obtained from healthy individuals or patients on immunosuppressive therapy who had received two to four doses of COVID-19 vaccines and from COVID-19 convalescents. The results show that anti-RBDwt titers correlate with the levels of binding- and neutralizing antibodies against the Alpha, Beta, Gamma, Delta, Epsilon and Omicron variants. The benefit of multiplexed analysis lies in the ability to measure a wide range of anti-RBD titers using a single dilution of serum for each assay. The reactivity patterns also yield an internal reference for neutralizing activity and binding antibody units per milliliter (BAU/ml). Results obtained with sera from vaccinated healthy individuals and patients confirmed and extended results from previous studies on time-dependent waning of antibody levels and effects of immunosuppressive agents. We conclude that anti-RBDwt titers correlate with levels of neutralizing antibodies against VOCs and propose that our method may be implemented to enhance the precision and throughput of immunomonitoring.
Development of InDel markers for interspecific hybridization between hill pigeons and feral pigeons based on whole-genome re-sequencing
Authors: Kim Jin-Yong , Hwang Jung Eun , Eo Soo Hyung , Kang Seung-Gu , Moon Jeong Chan , Kim Jung A , Park Jin-Young , An Junghwa , Yeo Yonggu , Yoon Jongmin 
Published: December 2022

AbstractInterspecific hybridization occurs among birds, and closely related sister taxa tend to hybridize at a high rate. Genomic hybridization markers are useful for understanding the patterns and processes of hybridization and for conserving endangered species in captivity and the wild. In this study, we developed genomic hybridization markers for the F1 progeny of the sister taxa feral pigeons (Columba livia var. domestica) and endangered hill pigeons (Columba rupestris) (family Columbidae). Using whole-genome re-sequencing data, we performed genome-wide analysis for insertion/deletion (InDel) polymorphisms and validated using primers. We conducted polymerase chain reaction (PCR) and agarose gel electrophoresis to identify species-specific InDels. We produced eight F1 hybrids of hill and feral pigeons, and their samples were tested by re-performing analyses and sequencing using 11 species-specific InDel polymorphisms. Eight InDel markers simultaneously amplified two DNA fragments from all F1 hybrids, and there was no abnormality in the sequencing results. The application of genomic tools to detect hybrids can play a crucial role in the assessment of hybridization frequency in the wild. Moreover, systematic captive propagation efforts with hybrids can help control the population decline of hill pigeons.
Evaluation of ability to withstand short circuit and development of large capacity 500 kV autotransformer
Authors: Li Zhongxiang , Tan Yanghong , Li Yong , Lin Xiaoqing , Liu Jun , Wang Shaoyang , Zhong Hao , Zhu Yiqin 
Published: December 2022

AbstractOnce the short circuit damage accident of a large capacity 500 kV transformer occurs suddenly, it will seriously affect the safe operation of the power grid. The article expounds on the calculation principle and evaluation method of the transformer's ability to withstand short circuit, then introduces the design structure of 400 MVA/500 kV short circuit autotransformer and calculates the electromagnetic force and evaluates the ability to withstand short circuit under high voltage ‐ medium voltage (HV‐MV) and medium voltage ‐ low voltage (MV‐LV) conditions. By comparing with typical 110 kV and 220 kV transformers, the short‐circuit characteristics are analysed, the control strategy is proposed, and the largest capacity short circuit prototype with 400 MVA/500 kV autotransformer is developed. Last, the sudden short circuit test is carried out in the large current test centre. The results show that the large capacity autotransformer passed the big current impulse under HV‐MV and MV‐LV short circuit conditions for the first time in the world, and all indicators are good, which confirms the accuracy of the strength check and the effectiveness of the short circuit evaluation method and also proves that the 500 kV autotransformer has strong strength to withstand short circuits.
Chinese Herbs for Pharyngitis Including COVID-19-Related Sore Throat
Authors: Jin Guanyuan , Jin Louis Lei 
Published: December 2022

AbstractSore throat is one of the most prominent clinical manifestations seen among mild cases of coronavirus disease 2019 (COVID-19). Traditional Chinese medicine (TCM) modalities, especially Chinese herbs, have accumulated rich experience in successfully treating sore throats in both acute and chronic pharyngitis. By sharing a real-world case study of three patients suffering pharyngeal discomfort including sore throat that might be related to the new coronavirus infection and have similar manifestations to general viral-induced pharyngitis, the article systematically presents and summarizes key Chinese herbs for acute and chronic pharyngitis based on TCM herbal prescriptions (principles of herbal formula writing) below: clearing heat and removing toxins, nourishing yin and the throat, loosening the stools and soothing the throat, along with TCM syndrome differentiation or disease differentiation and treatment. Moreover, a modern interpretation of these principles in terms of the relationship between Shanghuo and Fire Rising, which may often be characterized by local redness, swelling, fever, and pain in the mouth or throat along with possible inflammation, and the correspondence between the pharynx and the anus are proposed. Finally, the article will share their experience in applying specific herbs locally via various pharyngeal delivery modalities to improve efficacy including recommended prescriptions for a variety of acute and chronic pharyngitis, as well as those that may be caused by the new coronavirus infection.
“Tong Guan Li Qiao” Acupuncture Therapy on Post-Stroke Dysphagia
Authors: Huang Hongwen , Shi Huiyan , Ren Xuesong , Shi Xuemin 
Published: December 2022

AbstractThe differences between the “Tong Guan Li Qiao” acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows: first, it adheres to the basic idea of “Xing Nao Kai Qiao” acupuncture therapy in selecting and combining acupoints, centers on the brain, and combines the dysphagia symptoms of the mouth, tongue, and throat-related orifices with the root cause of “brain”; second, there are strict and standard requirements in the acupuncture operation, that is, manipulation quantification. In addition to standardized twirling, lifting, and thrusting, the techniques of deep needling on the acupoints in the neck region, blood-letting puncturing at the posterior wall of the pharynx, and the needling sensation of “like a fishbone getting stuck in the throat” are all unique.
Third Ventricular Epidermoid Tumor in a Pediatric Case
Authors: Yuksek Muhammed Erkam , Arac Densel , Erdi Mehmet Fatih 
Published: December 2022

AbstractEpidermoid tumors, which constitute 0.2 to 1.8% of primary intracranial neoplasms, occur in the third and fifth weeks of fetal development. Epidermoid tumors, which are known to occur most frequently in the cerebellopontine angle, are rarely located intraventricularly. A third ventricular location can be seen in 0.7% of cases. Epidermoid tumors are more common between the ages of 19 and 69, and are very rare in the pediatric period. In this report, we present a third ventricular epidermoid tumor in an 11 years old pediatric patient.
Sizable spin-to-charge conversion in PLD-grown amorphous (Mo, W)Te2−x
films
Authors: Sun Wenxuan , Chen Yequan , Zhuang Wenzhuo , Chen Zhongqiang , Song Anke , Liu Ruxin , Wang Xuefeng 
Published: December 2022

Abstract
We report on the spin-to-charge conversion (SCC) in Mo0.25W0.75Te2−x
(MWT)/Y3Fe5O12 (YIG) heterostructures at room temperature. The centimeter-scale amorphous MWT films are deposited on liquid-phase-epitaxial YIG by pulsed laser deposition technique. The significant SCC voltage is measured in the MWT layer with a sizable spin Hall angle of ∼0.021 by spin pumping experiments. The control experiments by inserting MgO or Ag layer between MWT and YIG show that the SCC is mainly attributed to the inverse spin Hall effect rather than the thermal or interfacial Rashba effect. Our work provides a novel spin-source material for energy-efficient topological spintronic devices.
System matrix recovery based on deep image prior in magnetic particle imaging
Authors: Yin Lin , Guo Hongbo , Zhang Peng , Li Yimeng , Hui Hui , Du Yang , Tian Jie 
Published: December 2022

Abstract

Objective. Magnetic particle imaging (MPI) is an emerging tomography imaging technique with high specificity and temporal-spatial resolution. MPI reconstruction based on the system matrix (SM) is an important research content in MPI. However, SM is usually obtained by measuring the response of an MPI scanner at all positions in the field of view. This process is very time-consuming, and the scanner will overheat in a long period of continuous operation, which is easy to generate thermal noise and affects MPI imaging performance. Approach. In this study, we propose a deep image prior-based method that prominently decreases the time of SM calibration. It is an unsupervised method that utilizes the neural network structure itself to recover a high-resolution SM from a downsampled SM without the need to train the network using a large amount of training data. Main results. Experiments on the Open MPI data show that the time of SM calibration can be greatly reduced with only slight degradation of image quality. Significance. This study provides a novel method for obtaining SM in MPI, which shows the potential to achieve SM recovery at a high downsampling rate. It is expected that this study will increase the practicability of MPI in biomedical applications and promote the development of MPI in the future.
Spatial autocorrelation method for simple microtremor array survey at rock/stiff-soil sites
Authors: Cho Ikuo 
Published: December 2022

SUMMARYIt is shown that the phase velocities of Rayleigh waves can be identified with a very simple microtremor array even at a rock or stiff-soil site. The main problem at rock/stiff-soil sites is the low signal-to-noise ratio, which is addressed in this study by applying a zero-crossing method, which is one form of a technique called spatial autocorrelation (SPAC). This method uses zero-crossing frequencies of the SPAC-coefficient spectrum to identify the phase velocities, modelled by the zeroth-order Bessel function of the first kind. A simple array, such as a linear array, can cause biases called directional aliasing, depending on the wavefield directionality. A systematic, theoretical examination of directional aliasing was made in this study to determine a practical shape for microtremor arrays, as well as to develop an improved scheme for reading the zero-crossing points of a SPAC coefficient curve. It is shown that, for an L-shaped array consisting of two independent linear arrays, the SPAC-coefficient curve can include biases in the frequency range immediately higher than the first zero-crossing point. In this study, based on these results, later zero-crossing points were not read depending on the indicator of possible biases, or the amplitude of the SPAC-coefficient curve immediately after the zero-crossing point. This systematic study also reveals that, for L-shaped arrays, although the first zero-crossing point is sometimes obscured (e.g. it appears to just touch the zero line rather than cross it), the biases of directional aliasing decrease as the intersection angle of the two linear arrays approaches a right angle. Therefore, an L-shaped array with a right angle is selected in this study as the simplest practical array, and a criterion for reading the first zero-crossing point is devised. It is shown that obscured zero-crossing points can be appropriately read, in general, by checking the systematic change in the zero-crossing frequency with array radius. Once the first zero-crossing point is thus appropriately read, we can identify accurate phase velocities. To test the feasibility of these theoretical findings, microtremor array data were acquired at 15 sites in the northern Kanto region, Japan, with an average S-wave velocity to a depth of 30 m (Vs30) based on velocity log data ranging from 182 to 1433 m s−1 (i.e. 14 sites with rock/stiff-soil and a site with relatively soft soil). The microtremor arrays were L-shaped, consisting of two independent linear arrays with lengths of 24 m. Each linear array consisted of seven unequally spaced 4.5-Hz geophones. Microtremors were recorded for about 20 min for each measurement. The soil parameters Vs10, Vs20 and Vs30 and S-wave velocity structure models were evaluated based on the obtained phase-velocity dispersion curves. The analysis results for the microtremor array data were in good agreement with values based on velocity logging.
A narrative review of the intermediate category of the antimicrobial susceptibility test: relation with dosing and possible impact on antimicrobial stewardship
Authors: Yusuf Erlangga , Zeitlinger Markus , Meylan Sylvain 
Published: December 2022

Abstract
The interpretation of ‘susceptible (S)’ or ‘resistant (R)’ results of antimicrobial susceptibility testing is easily understood, but the interpretation of the ‘intermediate (I)’ category can be confusing. This review critically discusses how this categorization (clinical breakpoints) comes into being with the emphasis on the use of pharmacokinetics and pharmacodynamic data. It discusses the differences between the ‘I’ according to the CLSI and the EUCAST. This review also discusses the recent EUCAST change of the ‘I’ definition, and the impact of this change from laboratory and clinical points of view.
Investigating the radiative properties of LHAASO J1908 + 0621
Authors: Wu Keyao , Zhou Liancheng , Gong Yunlu , Fang Jun 
Published: December 2022

ABSTRACT
LHAASO J1908+0621 has recently been detected as a source emitting γ-rays with energies above 100 TeV, and multiband observations show that a break around 1 TeV appears in the γ-ray spectrum. We have reanalysed the GeV γ-ray properties of the 100-TeV source using 14 years of data recorded by the Fermi Large Area Telescope (Fermi-LAT). The spectrum in the energy range range 30–500 GeV has an index of 1.50 ± 0.26, which is much smaller than that detected in TeV γ-rays. Additionally, the radiation properties of this source are investigated based on a one-zone time-dependent model. In the model, LHAASO J1908+0621 is associated with a pulsar wind nebula (PWN) powered by the pulsar PSR J1907 + 0602. High-energy particles composed of electrons and positrons are injected into the nebula. Multiband non-thermal emission is produced via synchrotron radiation and inverse Compton scattering (ICS). Taking the effect of radiative energy losses and adiabatic cooling into account, the spectral energy distribution from a model with a broken power law for the distribution of the injected particles can explain the fluxes detected in the γ-ray bands. The results support the idea that LHAASO J1908 + 0621 originates from the PWN powered by PSR J1907 + 0602, and γ-rays with energy above 100 TeV are produced by electrons/positrons in the nebula via ICS.
Constraining mass, radius, and tidal deformability of compact stars with axial wI modes: new universal relations including slow stable hybrid stars
Authors: Ranea-Sandoval Ignacio F , Mariani Mauro , Lugones Germán , Guilera Octavio M 
Published: December 2022

ABSTRACT
We revisit asteroseismology with quadrupolar wI modes and present universal relationships for its fundamental and first overtone. In contrast to relationships proposed in the literature, our universal relationships are capable of including slow stable hybrid stars that appear when considering slow sharp hadron-quark phase transitions. We show that if the frequency and damping time of the fundamental mode of a given pulsating object are measured, its mass, radius, and dimensionless tidal deformability can be inferred. Moreover, we show that the errors of such estimates are smaller than a few per cent for the mass and radius. For the dimensionless tidal deformability, the errors are – for compact objects with $M\gtrsim 1.4\, \mathrm{M}_\odot$ – in general smaller than $\sim 100 \, {{\ \rm per\ cent}}$. Comparison with previous universal relationships shows that the ones proposed in this work produce better estimates of the mass and radius of totally stable compact objects.
The quadrupole in the local Hubble parameter: first constraints using Type Ia supernova data and forecasts for future surveys
Authors: Dhawan Suhail , Borderies Antonin , Macpherson Hayley J , Heinesen Asta 
Published: December 2022

ABSTRACT
The cosmological principle asserts that the Universe looks spatially homogeneous and isotropic on sufficiently large scales. Given its fundamental implications, it is important to empirically test its validity. In this paper, we use the Type Ia supernova (SN Ia) magnitude–redshift relation, from both the Pantheon and joint light-curve analysis compilations, to constrain theoretically motivated anisotropies in the Hubble flow. In particular, we constrain the quadrupole in the effective Hubble parameter and the dipole in the effective deceleration parameter. We find no significant quadrupole term regardless of the redshift frame used. Our results are consistent with the theoretical expectation of a quadrupole moment of a few percent at scales of ∼100 h−1 Mpc. We place an upper limit of an $\sim 10{{\%}}$ quadrupole amplitude relative to the monopole, H0, at these scales. We find that we can detect an $\sim 7{{\%}}$ quadrupole at the 5σ level, for a forecast low-z sample of 1055 SNe Ia. We find the signficance of an exponentially decaying dipole of the deceleration parameter depends on the redshift frame used. In the heliocentric frame, as expected, it is detected at ∼3σ significance. In the cosmic microwave background (CMB) rest frame, we find a marginal ∼2σ dipole, however, after applying peculiar velocity (PV) corrections, the dipole is insignificant. Finally, we find the best-fitting frame of rest relative to the supernovae to differ from that of the CMB at ∼2σ for both compilations, which reduces to &lt;1σ when including PV covariance.
Unexpected no significant soil carbon losses in the Tibetan grasslands due to rodent bioturbation
Authors: Huang Miao , Gan Dezhao , Li Zheng , Wang Jinsong , Niu Shuli , Zuo Hongchao , Long Ruijun , Ma Lei 
Published: December 2022

AbstractThe Tibetan grasslands store 2.5% of the Earth’s soil organic carbon. Unsound management practices and climate change have resulted in widespread grassland degradation, providing open habitats for rodent activities. Rodent bioturbation loosens topsoil, reduces productivity, changes soil nutrient conditions, and consequently influences the soil organic carbon stocks of the Tibetan grasslands. However, these effects have not been quantified. Here, using meta-analysis and upscaling approaches, we found that rodent bioturbation impacts on the Tibetan grassland soil organic carbon contents were depth-dependent, with significant (P &lt; 0.001) decreasing of 24.4% in the topsoil (0 to 10 cm) but significant (P &lt; 0.05) increasing of 35.9% in the deeper soil layer (40 to 50 cm), and nonsignificant changes in other soil layers. The depth-dependent responses in soil organic carbon content were closely associated with rodent tunnel burrowing, foraging, excrement deposition, and mixing of the upper and deeper soil layers. Rodent bioturbation had shown nonsignificant impacts on soil bulk density, independent of soil layer. Tibetan grasslands totally lose −35.2 Tg C yr–1 (95% CI: −48.5 to −21.1 Tg C yr–1) and –32.9 Tg C yr–1 (−54.2 to −8.6 Tg C yr–1) due to rodent bioturbation in the 0 to 10 or 0 to 30 cm soil layer, while no significant net loss was found over the 0 to 90 cm layer. Our findings highlight the importance of considering depth-dependent factors to robustly quantify the net changes in the terrestrial soil organic carbon stocks resulting from disturbances such as rodent bioturbation.
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids
Authors: Wu Shengde , Ellison Corie , Naciff Jorge , Karb Michael , Obringer Cindy , Yan Gang , Shan Yuqing , Smith Alex , Wang Xiaohong , Daston George P 
Published: December 2022

AbstractThe purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data, and physiologically based pharmacokinetic (PBPK) models to support read-across for a series of branched carboxylic acids using valproic acid (VPA), a known developmental toxicant, as a comparator. The chemicals included 2-propylpentanoic acid (VPA), 2-ethylbutanoic acid, 2-ethylhexanoic acid (EHA), 2-methylnonanoic acid, 2-hexyldecanoic acid, 2-propylnonanoic acid (PNA), dipentyl acetic acid or 2-pentylheptanoic acid, octanoic acid (a straight chain alkyl acid), and 2-ethylhexanol. Transcriptomics was evaluated in 4 cell types (A549, HepG2, MCF7, and iCell cardiomyocytes) 6 h after exposure to 3 concentrations of the compounds, using the L1000 platform. The transcriptional profiling data indicate that 2- or 3-carbon alkyl substituents at the alpha position of the carboxylic acid (EHA and PNA) elicit a transcriptional profile similar to the one elicited by VPA. The transcriptional profile is different for the other chemicals tested, which provides support for limiting read-across from VPA to much shorter and longer acids. Molecular docking models for histone deacetylases, the putative target of VPA, provide a possible mechanistic explanation for the activity cliff elucidated by transcriptomics. In vitro toxicokinetic data were utilized in a PBPK model to estimate internal dosimetry. The PBPK modeling data show that as the branched chain increases, predicted plasma Cmax decreases. This work demonstrates how transcriptomics and other mode of action-based methods can improve read-across.