bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining assisted suicide and euthanasia through the lens of healthcare quality
Authors: Colleran Miriam , Doherty Anne M. 
Published: June 2023

AbstractMany people on both sides of the debate to legalise physician-hastened death are motivated by compassion and a desire to provide better end of life care for others. Assisted dying may include euthanasia and/or assisted suicide (EAS). It is legal in some jurisdictions and under debate in others including Ireland. EAS is a complex, sensitive and can be an emotive issue; detailed and nuanced examination of the subject is needed. To enhance this discussion, we examine EAS through the lens of quality. In examining EAS from this stance, we consider the action, along with the outcomes, the impact of the outcomes from other jurisdictions with legalised EAS, alongside the risks and the balancing measures used, in addition to considering the intervention itself. Progressive expansion of eligibility for EAS has occurred over time in the Netherlands, Belgium and Canada. Given the complexity of assessing coercion, the risks to persons in vulnerable groups (including older persons, persons with mental health conditions and persons with disabilities), the progressive expansion of eligibility for EAS, the lack of safety and the undermining of suicide prevention strategies, the current law is most protective of persons in vulnerable groups in the interest of social justice. Person-centred and compassionate care needs be prioritised with greater access and equitable access to primary and specialist palliative care and mental health care for persons with incurable and terminal illnesses and support for caregivers allowing patients to die naturally with optimised symptom control.
Enhanced Vulnerability of Asylum Seekers in Times of Crisis
Authors: Phillips Stephen 
Published: June 2023

AbstractThis article examines the impact of law and policy changes enacted in times of crisis on asylum seekers, and considers the extent to which considerations of vulnerability have played a part in the various approaches of governments. What emerges is a shift towards further exclusion, and a widening divide between how states approach citizens versus others. The result is enhanced vulnerability, and an environment in which the utility of the vulnerability concept to provide the necessary levels of support and protection is tested. By looking at how vulnerability is used by states, and contrasting this use with how the concept is often used by other community actors, the article asks what role the concept of vulnerability might play in the effects of crises on vulnerable groups and the priorities and actions of states.
Working with Natural Processes: Restoring a Mining Landscape in the High Arctic, Svalbard, Norway
Authors: Erikstad Lars , Hagen Dagmar , Simensen Trond 
Published: June 2023

AbstractThe Svea coal mines in Svalbard have been closed, and the area is under restoration. The goal of the landscape restoration was to enable dynamic ecological and geomorphological processes by removing roads, housing, industrial facilities, airports, landfills, and quarries that once dominated the area. Cultural heritage features, such as pre-1946 buildings, structures, and mining traces, have been preserved, while the rest of the landscape has been restored to a near-natural state. The focus has been restoring geodiversity in this arctic environment, where biotic processes are slow. Geomorphological processes such as glacial, slope, fluvial, coastal, and permafrost processes dominate and give the landscape its geological character. The objective of the restoration is not merely to re-create the landscape’s previous appearance but rather to ensure that natural processes can function as they did in the past, contributing to the ongoing development and evolution of all restored land surfaces. As of 2023, most of the area has already been restored. In areas with rapid geomorphological processes, the land will soon be dominated by these processes. Revegetation is one of the major ecological processes the restoration seeks to facilitate. Revegetation is a slow process in arctic environments, and it will take many decades before vegetation covers restored bare surfaces. The project forms a valuable baseline for studying and discussing geomorphology, landscape dynamics, geodiversity, biodiversity, and ecology for nature management and landscape restoration.
Regularization of limited memory quasi-Newton methods for large-scale nonconvex minimization
Authors: Kanzow Christian , Steck Daniel 
Published: June 2023

AbstractThis paper deals with regularized Newton methods, a flexible class of unconstrained optimization algorithms that is competitive with line search and trust region methods and potentially combines attractive elements of both. The particular focus is on combining regularization with limited memory quasi-Newton methods by exploiting the special structure of limited memory algorithms. Global convergence of regularization methods is shown under mild assumptions and the details of regularized limited memory quasi-Newton updates are discussed including their compact representations. Numerical results using all large-scale test problems from the CUTEst collection indicate that our regularized version of L-BFGS is competitive with state-of-the-art line search and trust-region L-BFGS algorithms and previous attempts at combining L-BFGS with regularization, while potentially outperforming some of them, especially when nonmonotonicity is involved.
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy
Authors: Dogbey Dennis Makafui , Torres Valeria Esperanza Sandoval , Fajemisin Emmanuel , Mpondo Liyabona , Ngwenya Takunda , Akinrinmade Olusiji Alex , Perriman Adam W. , Barth Stefan 
Published: June 2023

AbstractThe burden of cancer is increasing globally. Several challenges facing its mainstream treatment approaches have formed the basis for the development of targeted delivery systems to carry and distribute anti-cancer payloads to their defined targets. This site-specific delivery of drug molecules and gene payloads to selectively target druggable biomarkers aimed at inducing cell death while sparing normal cells is the principal goal for cancer therapy. An important advantage of a delivery vector either viral or non-viral is the cumulative ability to penetrate the haphazardly arranged and immunosuppressive tumour microenvironment of solid tumours and or withstand antibody-mediated immune response. Biotechnological approaches incorporating rational protein engineering for the development of targeted delivery systems which may serve as vehicles for packaging and distribution of anti-cancer agents to selectively target and kill cancer cells are highly desired. Over the years, these chemically and genetically modified delivery systems have aimed at distribution and selective accumulation of drug molecules at receptor sites resulting in constant maintenance of high drug bioavailability for effective anti-tumour activity. In this review, we highlighted the state-of-the art viral and non-viral drug and gene delivery systems and those under developments focusing on cancer therapy.Graphical Abstract
A classification of harmonic weak Maaß forms of half-integral weight
Authors: Alfes-Neumann Claudia , Raum Martin 
Published: June 2023

AbstractWe classify Harish-Chandra modules generated by the pullback to the metaplectic group of harmonic weak Maaß forms with exponential growth allowed at the cusps. This extends work by Schulze-Pillot and parallels recent work by Bringmann–Kudla, who investigated the case of integral weights. We realize each of our cases via a regularized theta lift of an integral weight harmonic weak Maaß form. Harish-Chandra modules in both integral and half-integral weight that occur need not be irreducible. Therefore, our display of the role that the theta lifting takes in this picture, we hope, contributes to an initial understanding of a theta correspondence for extensions of Harish-Chandra modules.
On Our Moral Entanglements with Wild Animals
Authors: O’Brien Gary David 
Published: June 2023

Abstract
In Just Fodder, Milburn argues for a relational account of our duties to animals. Following Clare Palmer, he argues that, though all animals have negative rights that we have a duty not to violate, we only gain positive obligations towards animals in the contexts of our relationships with them, which can be personal or political. He argues that human beings have collective positive duties towards domesticated animals, in virtue of the kind of relationship between us established by domestication. However, when it comes to wild animals, he argues that we have no such morally relevant relationships, and so we have only negative duties towards them. I argue that throughout history and even prehistory human beings have morally entangled themselves with wild animals sufficiently that we may in fact have collective positive duties towards many, if not all, wild animals.
General method for state-space modeling and nonlinear control of single-phase cascaded multilevel inverters with LCL coupling
Authors: Miralilu Hassan Manafi , Salimi Mahdi , Soltani Jafar , Akbarimajd Adel 
Published: June 2023

AbstractDue to the nonlinear behavior of grid-connected cascaded multilevel inverters (GCCMI), the use of nonlinear controllers can guarantee system stability over a wide range of operation. Therefore, state-space modeling is required to design nonlinear controllers. In this manuscript, a comprehensive method is proposed for the general state-space modeling of an n-level GCCMI with LCL coupling. To validate the accuracy of obtained state-space model, an experimental setup of a cascaded multilevel inverter including two H-bridges has been implemented. The outputs of the state-space model are compared with the simulation and experimental results of the GCCMI. This shows that the proposed model is compatible with a real closed-loop system. The simulations were performed using EMTDC/PSCAD software. In the following, the designed general model is used to develop a nonlinear controller based on the Lyapunov stability criteria for a multilevel shunt active power filter (SAPF). Results show that the designed controller is stable and robust in a wide range of operating point changes.
Linking Geodynamic Models of Basalt Segregation in Mantle Plumes to the X‐Discontinuity Observed Beneath Hotspots
Authors: Monaco Martina , Dannberg Juliane , Gassmoeller Rene , Pugh Stephen 
Published: June 2023

AbstractMantle plumes are thought to recycle material from the Earth's deep interior. One constraint on the nature and quantity of this recycled material comes from the observation of seismic discontinuities. The detection of the X‐discontinuity beneath Hawaii, interpreted as the coesite‐stishovite transition, requires the presence of at least 40% basalt. However, previous geodynamic models have predicted that plumes cannot carry more than 15%–20% of high‐density basaltic material. We propose this contradiction can be resolved by taking into account the length scale of chemical heterogeneities. While previous modeling studies assumed mechanical mixing on length scales smaller than the model resolution, we here model basaltic heterogeneities with length scales of 30–40 km, allowing for their segregation relative to the pyrolitic background plume material. Our models show that larger basalt fractions than previously thought possible—exceeding 40%—can temporarily accumulate within plumes at the depth of the X‐discontinuity. Two key mechanisms facilitate this process: (a) The random distribution of basaltic heterogeneities induces large temporal variations in the basalt fraction with cyclical highs and lows. (b) The high density contrast between basalt and pyrolite below the coesite‐stishovite transition causes ponding and accumulation of basalt within the rising plume at that depth. Because the statistical effect dominates, large values of 35%–40% basalt are only sustained temporarily. These results further constrain the chemical composition of the Hawaiian plume. Beyond that, they provide a geodynamic mechanism that explains the seismologic detection of the X‐discontinuity and highlights how recycled material is carried toward the surface.
Limited Northward Expansion of the Tibetan Plateau in the Late Cenozoic: Insights From the Cherchen Fault in the Southeastern Tarim Basin
Authors: Tian Hefeng , Chen Hanlin , Cheng Xiaogan , Wu Lei , Lin Xiubin , Gao Shibao , Li Feng , Xu Xi , Yin Qihang 
Published: June 2023

AbstractThe northern margin of the Tibetan Plateau is defined by the left‐lateral Altyn Tagh fault. It remains unclear whether the Cenozoic deformation related to the India‐Asia collision has remained stationary along the Altyn Tagh fault or propagated northward into the southeastern Tarim Basin. The Cenozoic Cherchen fault is located in the southeastern Tarim Basin, ∼90–120 km north of the Altyn Tagh fault, and thus, may play a critical role in addressing this issue. Here, we used a densely‐spaced two‐dimensional seismic reflection survey to investigate the geometry and kinematics of the Cherchen fault and understand its role in the expansion of the northern margin of the Tibetan Plateau. Our seismic study shows that the Cenozoic Cherchen fault is a high‐angle left‐lateral transpressional fault. Kinematic analysis of the Cherchen fault suggests that a restraining bend structure has formed along its central segment. Stratigraphic records suggest that the Cherchen fault initiated in the Paleozoic and reactivated during the middle Miocene (ca. 17–15.7 Ma). We infer that the dip‐slip and strike‐slip rates of the Cherchen fault are ∼0.09 mm/a and ∼1.66 mm/a, respectively. A regional cross section reveals that the northward expansion of the plateau is ongoing, but the range is limited to ∼90–120 km. We interpret that middle Miocene tectonic activity throughout the region was also concentrated along the northern plateau margin, defined by both northeast‐directed crustal shortening and northward expansion of the plateau.
Complex Drivers of Riparian Soil Oxygen Variability Revealed Using Self‐Organizing Maps
Authors: Lancellotti Brittany V. , Underwood Kristen L. , Perdrial Julia N. , Schroth Andrew W. , Roy Eric D. , Adair Carol E. 
Published: June 2023

AbstractOxygen (O2) regulates soil reduction‐oxidation processes and therefore modulates biogeochemical cycles. The difficulties associated with accurately characterizing soil O2 variability have prompted the use of soil moisture as a proxy for O2, as O2 diffusion into soil water is much slower than in soil air. The use of soil moisture alone as a proxy measurement for O2 could result in inaccurate O2 estimations. For example, O2 may remain high during cool months when soil respiration rates are low. We analyzed high‐frequency sensor data (e.g., soil moisture, CO2, gas‐phase soil pore O2) with a machine learning technique, the Self‐Organizing Map, to pinpoint suites of soil conditions associated with contrasting O2 regimes. At two riparian sites in northern Vermont, we found that O2 levels varied seasonally, and with soil moisture. For example, 47% of low O2 levels were associated with wet and cool soil conditions, whereas 32% were associated with dry and warm conditions. Contrastingly, the majority (62%) of high O2 conditions occurred under dry and warm conditions. High soil moisture levels did not always lead to low O2, as 38% of high O2 values occurred under wet and cool conditions. Our results highlight challenges with predicting soil O2 solely based on water content, as variable combinations of soil and hydrologic conditions can complicate the relationship between water content and O2. This indicates that process‐based ecosystem and denitrification models that rely solely on soil moisture to estimate O2 may need to incorporate other site and climate‐specific drivers to accurately predict soil O2.
Timing and Provenance of Volcanic Fluxes Around the Permian‐Triassic Boundary Mass Extinction in South China: U‐Pb Zircon Geochronology, Volcanic Ash Geochemistry and Mercury Isotopes
Authors: Edward Oluwaseun , Paul André Navin , Bucher Hugo , Vérard Christian , Adatte Thierry , Sonke Jeroen E. , Schaltegger Urs , Vennemann Torsten 
Published: June 2023

AbstractAnomalous mercury (Hg) contents recorded near the Permian‐Triassic boundary (PTB) are often linked to Siberian Traps Large Igneous Province (STLIP) volcanism and the Permian‐Triassic boundary mass extinction (PTBME). However, mounting evidence indicates that the relation between STLIP volcanism and Hg “anomalies” is not straightforward. This study focuses on the timing and provenance of volcanic fluxes around the PTBME in South China. We constrain carbon isotope (δ13C) and Hg concentration and isotope records by utilizing high‐precision U‐Pb zircon ages from two expanded deep‐water marine sections spanning the Late Permian to Early Triassic in the Nanpanjiang Basin. Results reveal two episodes of Hg enrichment. The oldest episode predates the onset of a large negative δ13C excursion, which is documented to be older than 252.07 ± 0.130 Ma. The second episode occurred between 251.822 ± 0.060 and 251.589 ± 0.062 Ma, coinciding with the nadir of the δ13C excursion. Volcanic ash geochemistry and Hg isotope compositions suggest that mercury was mainly sourced from subduction‐related volcanic arc magmatism in the Tethys region, which peaked between 251.668 ± 0.079 and 251.589 ± 0.052 Ma. These results are compatible with suggestions that regional arc volcanism contributed to the causes of the PTBME in South China and provide evidence that Hg anomalies close to the PTB are not a reliable stratigraphic marker for the PTB extinction event. This study demonstrates that relations between volcanism, environmental perturbations and mass extinction during the Permian‐Triassic transition are better resolved with the aid of high‐precision U‐Pb zircon ages.
Thank You to Our 2022 Peer Reviewers
Authors: Beal Lisa M. , Chafik Léon , Fawcett Sarah , Friedrichs Marjorie A. M. , Gnanaseelan Chellappan , Goodkin Nathalie F. , Li Yuanlong , Mulligan Ryan P. , Nagai Takeyoshi , O’Callaghan Joanne (Joe) , Power Hannah E. , von Schuckmann Karina , Sherwood Christopher , Singh Arvind , Umlauf Lars , Wahlin Anna , Xu Fanghua , Zhou Lei 
Published: June 2023

Plain Language SummaryThank you to the 1528 reviewers who provided 2647 reviews during 2022 to ensure the high quality and integrity of JGR‐Oceans manuscripts.
Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium
Authors: Peng Yang , Chen Shi-ying , Wang Zhao-ni , Zhou Zi-qing , Sun Jing , Zhang Gui-an , Li Jia , Wang Lei , Zhao Jin-cun , Tang Xiao Xiao , Wang De-Yun , Zhong Nan-shan 
Published: June 2023

AbstractRepurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells (AECs) is a quick way to find novel treatments for COVID-19. Computational screening has found dicoumarol (DCM), a natural anticoagulant, to be a potential SARS-CoV-2 inhibitor, but its inhibitory effects and possible working mechanisms remain unknown. Using air-liquid interface culture of primary human AECs, we demonstrated that DCM has potent antiviral activity against the infection of multiple Omicron variants (including BA.1, BQ.1 and XBB.1). Time-of-addition and drug withdrawal assays revealed that early treatment (continuously incubated after viral absorption) of DCM could markedly inhibit Omicron replication in AECs, but DCM did not affect the absorption, exocytosis and spread of viruses or directly eliminate viruses. Mechanistically, we performed single-cell sequencing analysis (a database of 77,969 cells from different airway locations from 10 healthy volunteers) and immunofluorescence staining, and showed that the expression of NAD(P)H quinone oxidoreductase 1 (NQO1), one of the known DCM targets, was predominantly localised in ciliated AECs. We further found that the NQO1 expression level was positively correlated with both the disease severity of COVID-19 patients and virus copy levels in cultured AECs. In addition, DCM treatment downregulated NQO1 expression and disrupted signalling pathways associated with SARS-CoV-2 disease outcomes (e.g., Endocytosis and COVID-19 signalling pathways) in cultured AECs. Collectively, we demonstrated that DCM is an effective post-exposure prophylactic for SARS-CoV-2 infection in the human AECs, and these findings could help physicians formulate novel treatment strategies for COVID-19.
HDGF promotes gefitinib resistance by activating the PI3K/AKT and MEK/ERK signaling pathways in non-small cell lung cancer
Authors: Han Shuyan , Tian Zhihua , Tian Huifang , Han Haibo , Zhao Jun , Jiao Yanna , Wang Chunli , Hao Huifeng , Wang Shan , Fu Jialei , Xue Dong , Sun Hong , Li Pingping 
Published: June 2023

AbstractHepatoma-derived growth factor (HDGF) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC); however, whether HDGF affects gefitinib resistance in NSCLC remains unknown. This study aimed to explore the role of HDGF in gefitinib resistance in NSCLC and to discover the underlying mechanisms. Stable HDGF knockout or overexpression cell lines were generated to perform experiments in vitro and in vivo. HDGF concentrations were determined using an ELISA kit. HDGF overexpression exacerbated the malignant phenotype of NSCLC cells, while HDGF knockdown exerted the opposite effects. Furthermore, PC-9 cells, which were initially gefitinib-sensitive, became resistant to gefitinib treatment after HDGF overexpression, whereas HDGF knockdown enhanced gefitinib sensitivity in H1975 cells, which were initially gefitinib-resistant. Higher levels of HDGF in plasma or tumor tissue also indicated gefitinib resistance. The effects of HDGF on promoting the gefitinib resistance were largely attenuated by MK2206 (Akt inhibitor) or U0126 (ERK inhibitor). Mechanistically, gefitinib treatment provoked HDGF expression and activated the Akt and ERK pathways, which were independent of EGFR phosphorylation. In summary, HDGF contributes to gefitinib resistance by activating the Akt and ERK signaling pathways. The higher HDGF levels may predict poor efficacy for TKI treatment, thus it has the potential to serve as a new target for overcoming tyrosine kinase inhibitor resistance in combating NSCLC.
Upper critical solution temperature polymer assemblies via variable temperature liquid phase transmission electron microscopy and liquid resonant soft X-ray scattering
Authors: Korpanty Joanna , Wang Cheng , Gianneschi Nathan C. 
Published: June 2023

AbstractHere, we study the upper critical solution temperature triggered phase transition of thermally responsive poly(ethylene glycol)-block-poly(ethylene glycol) methyl ether acrylate-co-poly(ethylene glycol) phenyl ether acrylate-block-polystyrene nanoassemblies in isopropanol. To gain mechanistic insight into the organic solution-phase dynamics of the upper critical solution temperature polymer, we leverage variable temperature liquid-cell transmission electron microscopy correlated with variable temperature liquid resonant soft X-ray scattering. Heating above the upper critical solution temperature triggers a reduction in particle size and a morphological transition from a spherical core shell particle with a complex, multiphase core to a micelle with a uniform core and Gaussian polymer chains attached to the surface. These correlated solution phase methods, coupled with mass spectral validation and modeling, provide unique insight into these thermoresponsive materials. Moreover, we detail a generalizable workflow for studying complex, solution-phase nanomaterials via correlative methods.