bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, characterization, and antimicrobial activity of novel chitosan blended almond gum–nanosilica bionanocomposite film for food packaging applications
Authors: Thomas Ruby , Vincent Vinaya Thattil , Janarthanam Umapathy Manickam , Rajagopal Lakshmanan , Jay Skandha 
Published: September 2023

Abstract
Almond gum and varied concentrations of nanosilica (0.2, 0.4, 0.6, 0.8, and 1.0 wt%) were introduced into the chitosan polymer matrix by solution cast method to enrich the characteristics of the bionanocomposite film. The surface topography, thermal stability, crystalline nature, and functional moieties of the synthesized bionanocomposite films were characterized by SEM, TGA, XRD, and FT-IR. The UV–Vis spectrophotometer showed a maximum absorption wavelength for the film containing the highest concentration of nanosilica. Change in properties such as increased tensile strength, elongation and reduced water solubility, and swelling properties were observed for the bionanocomposite film containing 1.0 wt% nanosilica. In addition, the films exhibited excellent inhibition effect against Escherichia coli bacteria and Candida albicans fungus, which were proven by well diffusion assay method. The carrot slices packed in the bionanocomposite film containing the highest amount of nanosilica retained their freshness for a longer period of time, suggesting the film to be an effective and excellent food packaging material.
A semi-empirical model for predicting carbonation depth of RAC under two-dimensional conditions
Authors: Wang Jian , Ma Yawei 
Published: September 2023

Abstract
Recycled aggregate concrete has been widely used in practical engineering construction, and the carbonation resistance of buildings within their allowable strength range is currently urgently needed to be considered. By constructing a time prediction model for the carbonation depth of recycled concrete, the time when the complete carbonation zone reaches the depth of the steel bar inside the concrete can be determined, and then the carbonation life of the building can be determined. However, the current carbonation model for recycled aggregates (RAs) has theoretical and practical limitations. The existing semi-empirical model has not quantitatively considered the influence of particle sizes of RAs on the carbonation depth, but only qualitatively analyzed the effect of particle size on the carbonation depth. In practical applications, the existing models usually only determine the structural life under one-dimensional carbonation conditions in laboratory conditions, ignoring the fact that two-dimensional carbonation mainly occurs in actual engineering. In order to overcome these limitations, a semi-empirical model for predicting the carbonation depth of recycled concrete is proposed for life prediction of structural carbonation. Based on the replacement rate of RAs, external environmental influences, and the stress state of components, the particle size of RAs is considered in the carbonation depth prediction model, and model parameters are fitted by performing carbonation experiments on specimens with different mix ratios. The model is then validated by applying a large amount of existing experimental data to the fitted model, and the results show that the model has good applicability for the constructed components. Furthermore, the model is used to predict the carbonation life of the main components in actual engineering and considers two-dimensional carbonation. It was found that when the replacement rate of RAs was 40%, the predicted life of the main components after carbonation in actual engineering was close to the design life.
On the Limits of High-Performance Support
Authors: Wagle John P. , Cunanan Aaron J. , Sams Matt L. , Driggers Austin R. 
Published: September 2023

ABSTRACT
High-performance sport has experienced increasing emphasis on evidence-based practice and interdisciplinarity facilitated by integrating systems science, business management, and a rapidly expanding sport technology landscape. A major limitation of current approaches to performance support is they unduly constrain the conceptualization of high performance within precise boundaries. In contrast, we explore the notion of parallel incrementalism to guide the pursuit and support of athletic excellence. Given this context, we introduce the idea of performance-limiting factors (PLFs) to complement key performance indicators (KPIs) in informing performance support. Whereas KPIs directly influence or describe performance, PLFs are characteristics that indirectly affect performance in their current state. Considering human performance through the complex interaction of KPIs and PLFs will allow us to continue pushing the boundaries of high-performance sport.
Sir Edwin Lutyens and Queen Mary’s Dolls’ House
Authors: Bryan James E. 
Published: September 2023

Abstract
This article examines Queen Mary’s Dolls’ House—world renowned for its luxury, scope, and verisimilitude—as a telling anomaly in the work of the most prominent English traditionalist architect of the twentieth century, Sir Edwin Lutyens. Analyzing the biographical significance of the project in Lutyens’s career and personal life during the 1920s, this essay interprets the prodigious miniature Edwardian mansion as providing an analog reality and a virtual escape for a publicly esteemed but privately insecure architect.
Association Between Coronary Artery Calcium Score and Left Ventricular Diastolic Dysfunction in Patients with Hypertension
Authors: Kiel Parinda , Laoakkha Watthanai , Boonyasirinant Thananya , Kaolawanich Yodying 
Published: September 2023

Background: Left ventricular diastolic dysfunction (LVDD) and coronary artery calcium (CAC) are common in patients with hypertension and are strong predictors of cardiovascular events. Aim: This study aims to investigate the association between CAC and LVDD in patients with hypertension without coronary artery disease (CAD). Methods: Consecutive patients with hypertension who underwent echocardiography and non-contrast coronary CT were studied. CAC was quantified using the Agatston score. Patients with a history of CAD, AF or left ventricular ejection fraction (LVEF) <50% were excluded. Characteristics of patients with and without LVDD were compared and the association between LVDD and CAC was evaluated. Univariable and multivariable analyses were performed to determine the predictors of LVDD and high CAC (>median CAC). A p value of <0.05 was considered statistically significant. Results: A total of 250 patients were included, with a mean age of 64.3 ± 10.1 years, 59% women and 26.4% had diabetes. The prevalence of LVDD was 64.8% (grade I LVDD 48%; grade II LVDD 16.8%) and the median CAC score was 58.2 (interquartile range [IQR] 0.7–349.8). Patients with LVDD had a significantly higher median CAC score than those without LVDD (142.8 [IQR 18.8–514.8] versus 5.0 [IQR 0–64.4]; p<0.001). Multivariable analysis showed that the CAC score was independently associated with LVDD (OR 1.003; 95% CI [1.001–1.004]; p<0.001). Left atrial volume index and E-wave deceleration time were independently associated with high CAC (OR 1.05; 95% CI [1.01–1.09]; p=0.008 and OR 1.008; 95% CI [1.002–1.02]; p=0.01), respectively. Conclusion: CAC scoring was associated with LVDD in patients with hypertension.
¿Tomando seriamente a Dewey? Una revisión crítica del ideal de ciencia bien ordenada de Philip Kitcher
Authors: Mattarollo Livio 
Published: September 2023

En el marco del debate sobre el ideal de ciencia libre de valores, Philip Kitcher propone un ideal de ciencia bien ordenada. La fundamentación política y meta ética del ideal tiene dos versiones: la primera se inspira en el enfoque de John Rawls mientras que la segunda refiere a la idea de democracia como experiencia conjunta comunicada de John Dewey. El artículo sostiene que el planteo de Kitcher evidencia ciertas tensiones con la visión deweyana pues aquel mantiene una concepción formal de la democracia y una visión objetivista de sus valores estructurales precisamente dos puntos que intentaba superar refiriendo a Dewey.
Comparación ecotoxicológica al Cloruro de Sodio en Hydra vulgaris e Hydra viridissima
Authors: Barrera Herrera July Andrea , Espinosa Ramírez Adriana Janneth 
Published: September 2023

El aumento de la salinidad en los ecosistemas de agua dulce genera preocupación sobre los efectos adversos que puede provocar sobre las especies dulceacuícolas y el suelo. Las concentraciones óptimas de iones de sodio y calcio para que las especies del género Hydra tengan condiciones fisiológicas adecuadas son relativamente bajas. Este trabajo se enfocó en comparar la sensibilidad de H. vulgaris e H. viridissima frente al cloruro de sodio (NaCl). Las especies fueron mantenidas bajo condiciones de fotoperiodo, iluminación y temperatura controladas. Se obtuvieron las tasas de crecimiento y en ensayos de toxicidad aguda se calcularon las CE50 (Concentración efectiva media) y CL50 (Concentración letal media) como indicadores de la sensibilidad al NaCl. H. vulgaris fue más sensible al NaCl dado que la CL50-96h fue de 1,0 g/l NaCl (entre 0,8 – 1,2 g/l como intervalo de confianza al 95%), mientras que H. viridissima presentó una CL50-96h promedio de 2,6 g/l (entre 2,0 – 3,3 g/l como intervalo de confianza del 95%). Se considera que esta última fue más tolerante al NaCl, probablemente por la relación simbiótica con la microalga Chlorella vulgaris, ya que podría generar un efecto protector. Se espera que comprender el comportamiento de estos biomodelos respecto al aumento de la salinización permita la evaluación temprana de riesgos ecológicos en ecosistemas acuáticos tropicales.
Experimental exposure of rainbow trout eggs to water mould, Saprolegnia parasitica (Oomycota): intraspecific differences in pathogenicity
Authors: Hardy Tímea , Erdei Noémi , Sipos Dóra , Verebélyi Viktória , Eszterbauer Edit 
Published: September 2023

AbstractIn in vivo infection trials, rainbow trout eyed eggs were exposed to three Saprolegnia parasitica (Oomycota) isolates, which differed in biological and genetic characteristics. Infection prevalence, hatching rate, hatching dynamics of fish eggs were quantified, and the study was complemented with histopathology and phylogenetic analyses. We experimentally detected intraspecific differences in the pathogenicity of S. parasitica on rainbow trout eggs. The isolate from rainbow trout eggs was the most virulent to eggs of the same host, whereas isolates from carp skin and fry did not cause as much damage to the eggs. Comparing the outcome of two experimental settings, we confirmed that invasion of fish eggs is more effective by hyphae growth than by the actively moving zoospores. In addition, our findings highlighted that S. parasitica isolates with 100% identical ITS DNA sequences, could differ significantly in virulence. These isolates can be clearly distinguished based on a 650-bp DNA fragment of the DNA-directed RNA polymerase II subunit (RPB2) gene.
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model
Authors: Schindler Maximilian , Siegerist Florian , Lange Tim , Simm Stefan , Bach Sophia-Marie , Klawitter Marianne , Gehrig Jochen , Gul Sheraz , Endlich Nicole 
Published: September 2023

Background
FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes.

Methods
To identify drugs with potential to treat FSGS, we used a specific zebrafish screening strain to combine a high-content screening (HCS) approach with an in vivo model. This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry exclusively in podocytes (providing an indicator for podocyte depletion), as well as a circulating 78 kDa vitamin D—binding enhanced green fluorescent protein fusion protein (as a readout for proteinuria). To produce FSGS-like lesions in the zebrafish, we added 80 µM metronidazole into the fish water. We used a specific screening microscope in conjunction with advanced image analysis methods to screen a library of 138 drugs and compounds (including some FDA-approved drugs) for podocyte-protective effects. Promising candidates were validated to be suitable for translational studies.

Results
After establishing this novel in vivo HCS assay, we identified seven drugs or compounds that were protective in our FSGS-like model. Validation experiments confirmed that the FDA-approved drug belinostat was protective against larval FSGS. Similar pan-histone deacetylase inhibitors also showed potential to reproduce this effect.

Conclusions
Using an FSGS-like zebrafish model, we developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS.
SELECTION OF TECHNOLOGICAL PARAMETERS OF MODES FOR MANUAL ARC WELDING OF SHUT-OFF VALVES MADE OF STEEL ALLOYED WITH 3–4 % NICKEL
Authors: Khudyakov A. O. , Shafikov R. T. , Valiakhmetov R. I. , Golik A. V. , Matrosov E. A. , Korobov Yu. S. 
Published: September 2023

Body of ball valves can be manufactured from A350-LF3 steel according to the US standard ASTM A350, alloyed with nickel up to 4 %. This steel has a tendency to harden in the heat affected zone during welding. The results of computer simulation showed that cooling rates during shielded metal arc welding exceed the recommended range. This can lead to the formation of hardening structures, the development of cold cracks and a decrease in the performance properties of welded joints of ball valves made of A350-LF3 steel.
To prevent the formation of cold cracks, the preheating and concurrent heating temperatures were calculated. According to the results of computer simulation, it was found that pre-heating and concurrent heating provide the cooling rate of heat affected zone in the recommended range.
The technology has been developed for welding ball valves made of A350-LF3 steel with mounting nozzles. This technology prevents the formation of cold cracks and provides a high level of strength and toughness of welded joints. The high level of mechanical properties of welded joints is confirmed by results of mechanical tests and metallographic studies.
Variations in complete blood counts and cellular morphological alterations in blood smear of COVID-19 patients from a tertiary care center
Authors: Shankar Saranya , Nalla Mamatha , Shobhitha D , Kumari Ramya G , Pawar Jayasree G 
Published: September 2023

Corona viruses are a large family of viruses of which Corona virus disease 19 (COVID 19) infection evokes a hyperinflammatory response and severe acute respiratory distress syndrome in human beings. Complete blood count evaluation and peripheral smear examination is an essential tool for early diagnosis and management of COVID-19 positive patients.This study was aimed to evaluate the variations in complete blood counts (CBC) and changes in the cellular morphology in the blood smear in patients affected with COVID-19.This was an observational study, undertaken in a tertiary care center.The study included baseline blood samples from 96 proven COVID-19 positive cases. The samples were subjected for automated complete blood count analysis and peripheral smear examination.Thequantitative data were expressed by mean and Standard deviation. Qualitative categorical variables were expressed as numbers and percentages.Out of the total 96 cases, the most common quantitative finding was neutrophilic leukocytosis with relative lymphopenia. Five cases of absolute lymphopenia was observed. Majority of the cases had normal hemoglobin values and normal platelet counts. The characteristic morphological changes were seen in neutrophils and lymphocytes. The neutrophils showed presence of toxic granules, cytoplasmic vacuolations and hypolobation.The morphological alteration in lymphocytes included reactive lymphocytes with plasmacytoid and monocytoid morphology, large granular lymphocytes and Turk cells. Infrequent finding of leukoerythroblastic reaction was also observed in our study.To summarize, hematological investigation of COVID 19 cases may show several abnormal findings. Quantitative findings like Neutrophilia and lymphopenia were characteristic, whereas, the most common morphological alteration observed was atypical lymphocytes. Quantitative and qualitative alterations of hematological parameters are one of the investigations which would aid timely diagnosis of the disease. Toxic granules and cytoplasmic vacuolations in neutrophils may indicate ongoing sepsis in COVID 19 patients which in turn aids in efficient management of the patients to reduce the mortality rate.
Który naturalizm?
Authors: Cottingham John , Iwanicki Marcin , Teske Joanna Klara 
Published: September 2023

Przekład na podstawie: „Which Naturalism?”, New Blackfriars 2022: 1–16, DOI: https://doi.org/ 10.1111/nbfr.12765. Przekład za zgodą Autora.
Program „naturalizacji” bywa we współczesnej laickiej filozofii przedstawiany w opozycji do tradycyjnego teizmu. Biorąc jednak pod uwagę historię terminów „natura” i „naturalny”, widać brak ciągłości między tym, jak owe terminy są rozumiane obecnie, a jak rozumiano je w przeszłości. Nowożytny „naturalista”, który domaga się, by wszystkie zjawiska umieścić w dziedzinie tego, co naturalne, stawia tezę, którą wielu klasycznych, średniowiecznych i wczesnonowożytnych filozofów i teologów uznałoby za dość samooczywistą. Zmiana, która tu zaszła, nie polega na decyzji, by do dziedziny naturalnej włączyć to, co poprzednio było z niej wykluczone, lecz na zupełnie innym rozumieniu tejże dziedziny. W artykule argumentuję, że filozoficznie ciekawe jest nie tyle pytanie, czy powinniśmy być naturalistami, ile pytanie, który z dwóch naturalizmów należy przyjąć: świecki naturalizm, z jego neutralistyczną koncepcją natury w ogóle i ludzkiej natury w szczególności, czy teistyczny naturalizm, wedle którego świat naturalny i nasza własna natura noszą znamię boskości. Okazuje się, że ujęcie sekularystyczne musi zmierzyć się z poważnymi wyzwaniami epistemicznymi i moralnymi.
Trudności nominalizmu tropowego – problem fundamentów podobieństwa i różnicy numerycznej
Authors: Piwowarczyk Marek 
Published: September 2023

Jeden z zarzutów wobec nominalizmu tropowego głosi, że tropy, wbrew deklaracjom ich zwolenników, muszą być złożone, co otwiera drogę do regresu, który da się zatrzymać, tylko przyjmując jakieś powszechniki. Złożoność tropów ma wynikać z tego, że relacja podobieństwa i relacja różnicy numerycznej, które zachodzą między doskonale podobnymi tropami, muszą mieć osobne fundamenty, stanowiące składniki tropów. Te fundamenty znów stoją w relacjach podobieństwa i różnicy, co generuje regres. W niniejszym artykule przyglądam się temu problemowi i próbuję odpierać argumentację przeciwników nominalizmu tropowego. Za punkt odniesienia czynię artykuł Pawła Rojka „Regresy podobieństwa. Podwójny relacyjny argument przeciw nominalizmowi tropowemu”, który w oryginalny sposób łączy ze sobą rożne zarzuty przeciw nominalizmowi tropowemu. Struktura mojego tekstu jest następująca: najpierw krótko charakteryzuję nominalizm tropowy i wskazuję, co mnie łączy z tym stanowiskiem (nie mogę bez zastrzeżeń określić siebie jako zwolennika nominalizmu tropowego). Następnie podaję charakterystykę relacji, w szczególności relacji podobieństwa, a potem przedstawiam argument Pawła Rojka. W kolejnym paragrafie staram się pokazać, że argument za złożonością tropów zakłada zasadę identyczności nieodróżnialnych, którą nominalista tropowy odrzuca. W przedostatniej sekcji wskazuję, że jednostkowość nie jest składnikiem tropu, lecz sposobem, w jaki trop konstytuuje rzeczywistość.
Wkład Zbigniewa Jordana w podtrzymywanie kontaktów polskiej filozofii emigracyjnej z filozofią krajową
Authors: Konstańczak Stefan 
Published: September 2023

Autor prezentuje mało znane fakty z historii polskiej nauki świadczące o tym, że przedstawiciele polskiej emigracji powojennej mieli bardzo dobre rozeznanie o sytuacji w nauce krajowej. W filozofii przykładem tego były kontakty Zbigniewa Jordana (1911–1977) z przedstawicielami filozofii pracującymi w kraju. Jordan przez wiele lat utrzymywał systematyczne kontakty z około czterdziestoma osobami, stanowiącymi elitę polskiej powojennej filozofii i socjologii. Do grona jego znajomych i korespondentów należeli m.in. Jan Łukasiewicz, ks. Józef Pastuszka, Tadeusz Czeżowski, Maria i Stanisław Ossowscy, Tadeusz i Janina Kotarbińscy, Adam Schaff, Leszek Kołakowski, Jan Szczepański, Andrzej Grzegorczyk, a także przedstawiciele polskiej emigracji pracujący na uczelniach zachodnich. Dzięki tym kontaktom potrafił zrealizować naraz dwa cele. Po pierwsze, popularyzował godne upamiętnienia osiągnięcia nauki polskiej, dzięki czemu jego starania zapewniały ścisły związek między nauką krajową a światową. Po drugie, zapewniał historyczna ciągłość nauki polskiej, której nie przerwało nawet wprowadzenie komunistycznych porządków w kraju, które sprowadzały się do próby odrzucenia całej dotychczasowej tradycji. Autor stoi na stanowisku, że nauka stanowi najważniejszą część kultury i z tej racji dokonania Jordana powinny zostać spopularyzowane w całym środowisku nauki w Polsce jako przykład, którym winni kierować się jej młodzi adepci, koncentrujący się wyłącznie na karierze w zagranicznych instytucjach naukowych.
Peningkatan Potensi Biji Kelor (Moringa oleifera) sebagai Pangan Pencegah Hiperkolesterolemia
Authors: Salman Annisa Nazifa , Prangdimurti Endang , Hunaefi Dase 
Published: September 2023

Moringa (Moringa oleifera) seeds contain good nutritional constituents and several components that can potentially reduce cholesterol levels, namely oleic acid, phytosterols, and dietary fiber. However, it tastes bitter, so it needs to be treated so that the bitter taste disappears but does not affect much of the content that can lower cholesterol. This study aims to get moringa seeds that are not bitter and have the potential to prevent hypercholesterolemia. The soaking treatment of peeled moringa seeds in either water or 3.5% NaCl salt, followed by 80 minutes of boiling, resulted in moringa flour with a very low bitter taste. The oleic acid content of the seed flour from soaking treatment with water or salt by boiling for 40 or 80 minutes is still high, in the range of 69–72%. Oleic acid is known to improve blood cholesterol profiles. The content of phytosterols, one of the cholesterol absorption inhibitors, from moringa flour treatment of 27–29 mg/100 g dw, is much higher than control flour (15 mg/100 g dw). The dietary fiber content of moringa seeds (total dietary fiber, soluble dietary fiber, insoluble dietary fiber) generally does not change after treatment. The results showed that soaking moringa seeds in water for 24 hours, followed by boiling for 80 minutes, produced moringa flour that can be used to develop hypercholesterolemia prevention foods.

Keywords: bitter taste, cholesterol, moringa seeds, oleic, phytosterol