bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Validity of Specific Immunoglobulin E Levels to alpha-gal in Alpha-gal Syndrome: A Cross-Sectional Analysis.
Authors: Sánchez Adrián Germán , Alonso-Llamazares Ana , García-González Fernando , Matala-Ahmed Bakai , Melgar-Reyes Ceny Solani , Antepara-Ercoreca Ignacio 
Published: July 2023

Abstract
Background: The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥0.35 kUA/L. The aim of this study was to evaluate the diagnostic validity of sIgE levels to alpha-gal ≥ 0.1 kUA/L for identifying AGS.
Methods: This was a cross-sectional analysis of adult patients with available data on sIgE levels to alpha-gal, classified into two groups according to the presence (Group 1) or absence (Group 2) of symptoms after being exposed to potential sources of alpha-gal. Values of sIgE to alpha-gal ≥ 0.1 kUA/l were considered a positive result. A descriptive analysis of internal and external validity parameters was performed in the entire population and adjusted by sex.
Results: The study included 33 individuals in Group 1 and 65 in Group 2, with a mean age of around 47 years. The analysis of internal validity parameters revealed a high sensitivity, specificity, and positive probability ratio, with higher sensitivity in men and higher specificity in women. The analysis of external validity parameters showed a high negative predictive value and global value in all populations and both sexes. However, the positive predictive value was relatively high in men, but low in women.
Conclusions: Our results suggest that sIgE levels ≥ 0.1 kUA/L may be a useful tool for the diagnosis of AGS, although other factors and diagnostic techniques should also be considered.
Comparison of post-operative pain and quality of life between total thoracoscopic surgery and conventional full-sternotomy for aortic valve replacement
Authors: Lin Zhiqin , Chen Xiujun , Dai Xiaofu , Xu Zheng , Chen Liangwan 
Published: July 2023

Abstract
Background
To compare the post-operative pain and quality of life of patients who underwent total thoracoscopic surgery (TTS) or conventional full-sternotomy (CFS) for aortic valve replacement (AVR).
Methods
We reviewed the records of 223 consecutive AVR patients with either TTS or CFS from January 2018 to December 2022. We used a visual analogue scale (VAS) and the Short Form-36 Health Survey (SF-36) to measure the post-operative pain and quality of life, respectively. We also compared the operative data and clinical outcomes between the two groups.
Results
The TTS group had lower adjusted mean VAS scores than the CFS group at all time points after surgery (at 1 to 3 days and at 3 and 6 months, p < .001 for all comparisons), indicating less pain. The TTS group also had higher mean SF-36 scores than the CFS group up to 6 months after surgery (p < .001 for all comparisons), indicating better quality of life. The operative time was similar between the two groups (p = .224), but the TTS group had longer cardiopulmonary bypass time and aortic cross-clamp time than the CFS group (p < .001). The TTS group had more pulmonary complications than the CFS group (p = .023). However, there were no significant differences in other major complications or mortality between the two groups.
Conclusions
TTS is a safe and effective alternative to CFS for AVR. TTS resulted in less pain and better quality of life, especially in the early recovery period. However, further prospective randomized controlled studies are needed to confirm our findings.
VIEWER: An electronic audit and feedback tool for the delivery of population health management applied to mental health care
Authors: Msosa Yamiko Joseph , Codling David , Wang Tao , Broadbent Matthew , Roberts Angus , Harland Robert , McGuire Philip , Stewart Rob , Dobson Richard JB 
Published: July 2023

Abstract

Background: Due to the burden and negative impacts of psychotic disorders, treatment alone is insufficient to reduce the gap in psychosis care thereby highlighting the need for greater investment in prevention strategies which are targeted towards an entire population to detect risk factors early and prevent adverse health outcomes at scale. This work evaluates the technical feasibility of implementing electronic audit and feedback (eA&F) to support population health management in mental health care by facilitating the visualisation of clinical health records to provide relevant summaries for eA&F.
Methods: A Participatory Design approach was adopted as an integral framework throughout the design and development of an eA&F platform. The eA&F platform, VIEWER, was evaluated for its technical feasibility. The feasibility testing of the platform was carried out with clinical teams in the context of three different clinical use cases to support eA&F for managing the psychosis patient population.
Results: An eA&F platform for supporting population health management was developed. The platform was used successfully for eA&F to support the identification of unmet needs, variations in care processes, and inequalities between groups of patients within the psychosis patient population.
Conclusions: It is technically feasible to develop and deploy an eA&F platform that supports population health management in secondary mental healthcare. Using advanced clinical analytics to integrate population-level data with routine clinical practice raises exciting possibilities of building more intelligent services that are adaptive to the needs of the population, and adopt a more proactive, preventative approach. The innovative eA&F platform gives clinicians the flexibility to look at clinical data that is relevant to them at the level of abstraction that is appropriate for the decision being made. By sharing the methods and steps taken in this work, useful insights can be provided to other researchers and practitioners that are developing similar digital health interventions.
An improved UAV image detection algorithm based on YOLOv5
Authors: Guo Yecai , Sun Jingdong , Saha Amitave 
Published: July 2023

Abstract
At present, existing small target detection methods suffer from low detection accuracy, high false detection rate and high leakage rate. In order to improve small target detection, this paper proposes the FSD-YOLOv5 algorithm, which has three improvements on the basis of the YOLOv5 algorithm. Firstly, the Focal EIoU is used instead of the original CIoU to improve the model convergence speed and regression accuracy; Secondly, in order to cope with the defects in the CNN architecture, we adopt a new CNN building block called SPD-Conv; Finally, to address the problem of the reduced or lost information of small objects in feature maps caused by downsampling in convolutional neural networks, we introduce feature reuse to increase the feature information of small objects in the feature maps. We evaluated FSD-YOLOv5 on the VisDrone-2019 dataset and compared its performance with YOLOv5. The results show that FSD-YOLOv5 achieves a detection accuracy of 36.3%, an improvement of 2.4% compared to the original algorithm. For small target detection, the FSD-YOLOv5 algorithm has better detection results than the YOLOv5 algorithm.
Genetic effect of metformin use on risk of cancers: Evidence from Mendelian randomization analysis
Authors: Chen Yao , Bai Bingjun , Ye Shuchang , Gao Xing , Ying Kangkang , Pan Hongming , Xie Binbin 
Published: July 2023

Abstract
Background Increasing number of studies reported the positive effect of metformin on the prevention and treatment of cancers. However, the genetic causal effect of metformin utilization on the risk of common cancers was not completely demonstrated.Methods Two-sample Mendelian Randomization (two-sample MR) analysis was conducted to uncover the genetically predicted causal association between metformin use and 26 kinds of cancers. Besides, two-step Mendelian Randomization (two-step MR) assessment was applied to clarify the mediators which mediated the causal effect of metformin on certain cancer. We utilized five robust analytical methods, in which the inverse variance weighting (IVW) method served as the major one. Sensitivity, pleiotropy, and heterogeneity were assessed. The genetic statistics of exposure, outcomes, and mediators were downloaded from publicly available datasets, including the Open Genome-Wide Association Study (GWAS), FinnGen consortium (FinnGen), and UK Biobank (UKB).Results Among 26 kinds of common cancers, HER-positive breast cancer was presented with a significant causal relationship with metformin use (Beta: -4.0982; OR: 0.0166 (95%CI: 0.0008, 0.3376); P-value: 0.0077), which indicated metformin could prevent people from HER-positive breast cancer. Other cancers only showed modest associations with metformin use. Potential mediators were included in two-step MR, among which total testosterone levels (mediating effect: 24.52%) displayed significant mediating roles. Leave-one-out, MR-Egger, and MR-PRESSO analyses produced consistent outcomes.Conclusion Metformin use exhibited a genetically protective effect on HER-positive breast cancer, which was partially mediated by total testosterone levels.
LncRNA WAC-AS1 promotes osteosarcoma metastasis and stemness by sponging miR-5047 to upregulate SOX2
Authors: Yang Zhining , Liu Zhaoyong , Lu Weiqing , Guo Huancheng , Chen Jianzhou , Zhang Ying 
Published: July 2023

Abstract
Cancer stemness and osteosarcoma (OS) malignant progression are closely associated. However, the molecular mechanisms underlying this association have not been fully demonstrated. Long noncoding RNAs (lncRNAs) are an intriguing class of widely prevalent endogenous RNAs involved in OS progression, the vast majority of which have not been characterized functionally. Here, we identified tumor promoter lncRNA WAC-AS1 to be highly expressed in OS tumors and associated with worse survival. Further analysis revealed that WAC-AS1 increased tumorsphere formation of OS cells and promoted metastasis, as confirmed by cell proliferation, transwell and wound healing assays. MiR-5047 was identified as a downstream target of WAC-AS1. Subsequently, based on bioinformatics analysis, RIP assay and luciferase reporter assay, SOX2 mRNA was verified as a target of miR-5047. WAC-AS1 enhanced OS cell proliferation and stemness via acting as a ceRNA by binding to miR-5047, thereby increasing SOX2 expression. In addition, SOX2 bound to the promoter region of WAC-AS1 and promoted its transcription, thereby forming a positive feedback loop to regulate OS malignancy. Taken together, our findings show WAC-AS1 is a tumor promoter and a key regulator of OS cell stemness and metastasis via a miR-5047/SOX2 axis.
Factors Influencing Preferences of Patients With Rheumatic Diseases Regarding Telehealth Channels for Support With Medication Use: Qualitative Study
Authors: Haegens Lex L , Huiskes Victor J B , van der Ven Jeffrey , van den Bemt Bart J F , Bekker Charlotte L 
Published: July 2023

Background
Patients with rheumatic diseases are known to experience drug-related problems at various times during their treatment. As these problems can negatively influence patients’ health, they should be prevented or resolved as soon as possible, for which patients might benefit from additional support. Telehealth has the potential to continuously provide information and offers the possibility to easily contact a health care provider in order to support patients with medication use. Knowledge of factors influencing the patient’s preference for telehealth channels can improve the actual use of telehealth channels.

Objective
This study aims to identify factors that influence the preferences of patients with rheumatic diseases regarding telehealth channels for support with medication use.

Methods
A qualitative study with face-to-face interviews was performed among patients with an inflammatory rheumatic disease in the Netherlands. A total of 4 telehealth channels were used: a frequently asked questions page, a digital human, an app for SMS text messaging with health care providers, and an app for video-calling with health care providers. Using a semistructured interview guide based on domains of the Capability, Opportunity, Motivation, and Behavior (COM-B) model, participants were questioned about (1) their general opinion on the 4 telehealth channels, (2) factors influencing preference for individual telehealth channels, and (3) factors influencing preference for individual telehealth channels in relation to the other available channels. Interviews were recorded, transcribed, and categorically analyzed.

Results
A total of 15 patients were interviewed (female: n=8, 53%; male: n=7, 47%; mean age 55, SD 16.8 years; median treatment duration of 41, IQR 12-106 months). The following 3 categories of factors influencing patient preference regarding telehealth channels were identified: (1) problem-related factors included problems needing a visual check, problems specifically related to the patient, and urgency of the problem; (2) patient-related factors included personal communication preference and patient characteristics; and (3) channel-related factors included familiarity with the telehealth channel, direct communication with a health care provider, methods of searching, and conversation history.

Conclusions
Preference for telehealth channels is influenced by factors related to the problem experienced, the patient experiencing the problem, and telehealth channel characteristics. As the preference for telehealth channels varies between these categories, multiple telehealth channels should be offered to enable patients to tailor the support with their medication use to their needs.
MOTIVASI KERJA PUSTAKAWAN LULUSAN NON ILMU PERPUSTAKAAN DI DINAS PERPUSTAKAAN DAN KEARSIPAN KABUPATEN TAKALAR
Authors: Trysnawati Ayu , Asmiranda Alda 
Published: July 2023

Abstract
This article examines the work motivation of non-library science graduate librarians at the Dinas Perpustakaan dan Kearsipan Kabupaten Takalar. The purpose of this study is to determine the factors that drive the work motivation of non-library science graduate librarians and to find out the obstacles faced by non-library science graduate librarians at the Dinas Perpustakaan dan Kearsipan Kabupaten Takalar in increasing work motivation. The type of research used is descriptive with qualitative methods. The results showed that the motivating factors for librarian motivation in working at the Dinas Perpustakaan dan Kearsipan Kabupaten Takalar were salary, job security, social conditions, awards and opportunities to work. While the obstacles faced by non-library science graduate librarians in increasing work motivation are obstacles to dealing with users, obstacles to working as a librarian, obstacles to technology, and constraints to library collections.

Abstrak

Artikel penelitian ini mengkaji tentang motivasi kerja pustakawan lulusan non ilmu perpustakaan di Dinas Perpustakaan dan Kearsipan Kabupaten Takalar. Tujuan dari penelitian ini yaitu untuk mengetahui faktor yang mendorong motivasi kerja pustakawan lulusan non ilmu perpustakaan dan mengeahui kendala yang dihadapi pustakawan lulusan non ilmu perpustakaan Di Dinas Perpustakaan dan Kearsipan Kabupaten Takalar dalam meningkatkan motivasi kerja. Jenis penelitian yang digunakan adalah deskriptif dengan metode kualitatif. Hasil penelitian menunjukkan bahwa faktor pendorong motivasi pustakawan dalam bekerja di Dinas Perpustakaan dan Kearsipan Kabupaten Takalar yaitu adanya gaji, keamanan kerja, kondisi sosial,penghargaan dan kesempatan untuk bekerja. Sedangkan kendala yang dihadapi pustakawan lulusan non ilmu perpustakaan dalam meningkatkan motivasi kerja adalah kendala menghadapi pemustaka, kendala bekerja sebagai seorang pustakawan, kendala terhadap teknologi, dan kendala terhadap koleksi perpustakaan.

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MUQADDIMAH IBNU KHALDUN: STUDY OF ISLAMIC HISTORIOGRAPHY
Authors: Abd. Rahim Ahmad Habib Akramullah , Susmihara  , Yani Ahmad 
Published: July 2023

Nama lengkap seorang Ibnu Khaldun adalah Abd al-Rahman bin Muhammad bin Mohammad bin Hasan bin Jabar bin Mohammad bin Ibrahim bin Abd al-Rahman bin Khaldun. Kemudian ia dilahirkan tepatnya daerah Tunisia, wilayah di Afrika Utara, sekitar pada tahun 732 H atau 1332 M, ia merupakan keluarga pendatang dari daerah Andalusia, wilayah di Spanyol Selatan, yang sekarang pindah ke daerah Tunisia sekitar pertengahan abad VII H. Asal mula keluarga seorang Ibnu Khaldun yang sebenarnya dari daerah Hadramaut, di wilayah Yaman selatan. Ibnu Khaldun memulai pendidikannya pada usia umur 18 tahun antara 1332 sampai 1350 M. Seperti halnya yang dilakukan kaum muslim pada waktu itu, ayah Ibn Khaldun adalah sosok guru pertama yang telah mendidiknya secara tradisional mengajarkan nilai-nilal dasar agama Islam. Semasa ia tinggal di daerah Tunisia sampai tahun 751 H, Ibnu Khaldun sangat tekun belajar dan giat membaca serta ia setiap saat menghadiri majelis gurunya yaitu, Muhammad Ibrahim Al-Abili. Pada saat itu Ibn Khaldun sudah beranjak usia 20 tahun. Dan waktu itu Ibn Khaldun dipanggil oleh Abu Muhammad Ibn Tarafkin salah seorang penguasa yang berada di daerah Tunisia untuk memangku jabatan sebagai sekretaris penguasa Sultan Abu Ishaq Ibn Abu Yahya Al-Hafsi. Ibn Khaldun ini merupakan salah satu seorang aktivis dan pemikir politik yang lahir di daerah Tunisa tahun 1332 dan ia meninggal di Mesir tahun 1406. Sebelum beliau wafat ia telah banyak menghabiskan sebagian umurnya dalam pertarungan dan petualangan politik dalam berbagai bentuknya, pada kurun waktu dan di sebagian dunia dimana ia hidup. Selain ia seorang aktivis politik, ia juga seorang ahli pemikir dan sangat mengamati ilmu pengetahuan yang ia memiliki dan ia seorang analisis yang amat tajam. Ia menuliskan hasil pengamatannya itu dalam sebuah buku yang terdiri dari beberapa jilid tentang sejarah, sebuah buku yang di namakannya “Ibar” yaitu buku yang menjadi suri teladan yang dapat diambil manusia dari sejarah. Bagian pertama dari buku itu dinamakannya “Muqaddimah”, yang artinya “Pendahuluan. Karya yang dilihat dari judulnya Al-Ibar wa Diwan Al-Mubtada wa Al-Khabar fi, Ayyam Al- Arab wa al-Ajam wa Al-Barbar, wa Man Asharahum min Dzawi Al- Sulthan Al-Akbar, dan terdiri beberapa beberapa jilid.
Analysis of clinical characteristics of 617 patients with benign airway stenosis
Authors: Wei Jinmei , Qin Shujuan , Li Wentao , Chen Yan , Feng Tingmei , Wei Yuhui , Tan Sen , Liu Guangnan 
Published: July 2023

IntroductionBenign airway stenosis (BAS), namely airway narrowing caused by a variety of benign lesions, can lead to varying degrees of breathing difficulties and even death due to asphyxia. This study aimed to elucidate the clinical characteristics of BAS, including etiology, treatment and pathology, by analyzing the clinical data of BAS patients.MethodsA retrospective analysis was conducted using the clinical data of 617 BAS cases from January 2017 to December 2022. The pathological characteristics of the tissues were assessed by hematoxylin–eosin (H&amp;E) and Masson’s staining. Besides, protein expression levels were determined by immunohistochemistry (IHC).ResultsA total of 617 patients were included (333 females [53.97%] and 284 males [46.03%]), with an average age of 48.93 ± 18.30 (range 14–87). Tuberculosis (n = 306, 49.59%) and trauma (n = 179, 29.02%) were the two leading etiologies of BAS, followed by airway foreign bodies (FB, n = 74, 11.99%), external compression (n = 25, 4.05%) and other etiologies (n = 33, 5.35%). Among 306 tuberculous tracheobronchial stenosis (TBTS) cases, most were females (n = 215, 70.26%), and TBTS mainly occurred in the left main bronchus (n = 97, 31.70%), followed by the right middle bronchus (n = 70 cases, 22.88%). The majority of TBTS patients (n = 259, 84.64%) were treated by interventional therapy. The condition of 179 BAS patients was ascribed to trauma, such as tracheal intubation (n = 92, 51.40%), tracheotomy (n = 69, 38.56%), injury (n = 15, 8.38%) and surgery (n = 3, 1.68%), which mostly took place in the trachea (n = 173, 96.65%). TAS patients mainly received interventional therapy (n = 168, 93.85%) and stent implantation (n = 47, 26.26%). The granulation tissues of BAS primarily featured inflammation, proliferation and fibrosis. IHC indicated the up-regulated expressions of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA), collagen type I protein (COL-I) and vimentin, and the down-regulated expression of E-cadherin, which indicated fibrosis and epithelial-mesenchymal transition (EMT).ConclusionTuberculosis was the main etiology, and trauma was the secondary etiology. The granulation tissues of BAS were characterized by inflammation, fibrosis and probably EMT. Comprehensive interventional therapy is an effective method of treating BAS.
Pregnant Mothers Perception About Covid-19 to Compliance with the Use of Mask at Mungkid Magelang Health Center
Authors: Atiqoh Salis , Rohmayanti Rohmayanti , Wijayanti Kartika 
Published: July 2023

Pregnant women are a susceptible group to covid-19 infection due to pregnant women, in general, are vulnerable to respiratory infection. One of the prevention measures is the use of masks which will help to protect against and limit the spread of Covid-19. This study contributes to identifying the relationship between perception and mask use adherence among pregnant women in Mungkin Public Health, Magelang. A cross-sectional study with 87 pregnant women was selected using the random sampling technique in Mungkin Health Center, Magelang. The questionnaire used was a perception questionnaire about Covid-19 with a validity test of r > 0.3 and a validity test of 0.721. The compliance questionnaire had a validity value of r table 0.3 and a validity test of 0.723, and the data were analyzed using the Spearman statistical test. The majority of respondents were aged 20–35 years, working (65.5%), with gestational age in the second trimester (63.2%), and in secondary education (82.8%). Most of the respondents have a moderate perception regarding mask use during Covid-19 (56.3%), and 23% have a good perception. Regarding adherence to mask use, 62 (71%) respondents have moderate adherence, and 18 (20%) have poor adherence. There is a statistically significant relationship between perception and mask use adherence among pregnant women in Magelang (p = 0.000). Since there is an association between perception and mask use adherence, interventions to promote mask use are needed among pregnant women.