bluuebunny/crossref_metadata_2025_split huggingface dataset:
An artificial intelligence approach for energy‐aware intrusion detection and secure routing in internet of things‐enabled wireless sensor networks
Authors: Aruchamy Prasanth , Gnanaselvi Sabeena , Sowndarya Devi , Naveenkumar Pushpalatha 
Published: May 2023

SummaryIn today's world, the Internet of things (IoT) and wireless sensor networks (WSNs) have been integrated into various applications to support reliable communication systems. The IoT nodes collect the sensed data with the aid of WSN and transfer them to the cloud environment. Nevertheless, these nodes become vulnerable when Denial of Service attacks occurred in the IoT‐enabled WSN (IWSN). The insecure route also affects the energy efficiency of IWSN. Therefore, robust intrusion detection along with secure routing is necessitated to protect the IWSN from various security threats. In this paper, a novel Artificial Intelligence‐based Energy‐aware Intrusion Detection and Secure Routing model has been proposed to develop a secured IWSN. Initially, the proposed model executes the intrusion detection system to identify the various attacks. Afterward, a game strategy‐based decision mechanism is integrated with the proposed intrusion detection model to decide whether protection is needed or not. In the last phase, an energy‐aware ad‐hoc on‐demand distance vector algorithm has been established to offer secured routing among multiple nodes. The performance results show that the proposed model achieves superior detection accuracy of 95% and reduced energy utilization of 38% as compared with the existing intrusion detection models.
Do investors incorporate financial materiality? Remapping the environmental information in corporate sustainability reporting
Authors: Xie Jun , Tanaka Yoshitaka , Keeley Alexander Ryota , Fujii Hidemichi , Managi Shunsuke 
Published: May 2023

AbstractAlthough the consideration of financial materiality is important for securing shareholders' interests, the degree of financial materiality that is considered for existing sustainability ratings is still questionable. In this study, we hand‐mapped the financial materiality of environmental information based on Sustainability Accounting Standards Board (SASB) industry‐specific accounting metrics to reassess environmental performance. Based on the SASB‐based environmental score, we tested whether investors price environmental risk. The results show significant pricing anomalies related to environmental risk. Companies with lower SASB‐based environmental scores experience higher environmental risk. Additionally, a premium in the cross‐section of stock returns compensates for this risk. Our findings suggest that integrating financial materiality based on the SASB could be an effective way to capture corporate environmental risk.
Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy
Authors: Shapiro Daniel D. , Zacharias Niki Millward , Tripathi Durga N. , Karki Menuka , Bertocchio Jean‐Philippe , Soeung Melinda , He Rong , Westerman Mary E. , Gao Jianjun , Rao Priya , Lam Truong N. A. , Jonasch Eric , Perelli Luigi , Cheng Emily H. , Carugo Alessandro , Heffernan Timothy P. , Walker Cheryl L. , Genovese Giannicola , Tannir Nizar M. , Karam Jose A. , Msaouel Pavlos 
Published: May 2023

AbstractBackgroundRenal medullary carcinoma (RMC) is a highly aggressive cancer in need of new therapeutic strategies. The neddylation pathway can protect cells from DNA damage induced by the platinum‐based chemotherapy used in RMC. We investigated if neddylation inhibition with pevonedistat will synergistically enhance antitumour effects of platinum‐based chemotherapy in RMC.MethodsWe evaluated the IC50 concentrations of the neddylation‐activating enzyme inhibitor pevonedistat in vitro in RMC cell lines. Bliss synergy scores were calculated using growth inhibition assays following treatment with varying concentrations of pevonedistat and carboplatin. Protein expression was assessed by western blot and immunofluorescence assays. The efficacy of pevonedistat alone or in combination with platinum‐based chemotherapy was evaluated in vivo in platinum‐naïve and platinum‐experienced patient‐derived xenograft (PDX) models of RMC.ResultsThe RMC cell lines demonstrated IC50 concentrations of pevonedistat below the maximum tolerated dose in humans. When combined with carboplatin, pevonedistat demonstrated a significant in vitro synergistic effect. Treatment with carboplatin alone increased nuclear ERCC1 levels used to repair the interstrand crosslinks induced by platinum salts. Conversely, the addition of pevonedistat to carboplatin led to p53 upregulation resulting in FANCD2 suppression and reduced nuclear ERCC1 levels. The addition of pevonedistat to platinum‐based chemotherapy significantly inhibited tumour growth in both platinum‐naïve and platinum‐experienced PDX models of RMC (p < .01).ConclusionsOur results suggest that pevonedistat synergises with carboplatin to inhibit RMC cell and tumour growth through inhibition of DNA damage repair. These findings support the development of a clinical trial combining pevonedistat with platinum‐based chemotherapy for RMC.
NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression
Authors: Zuo Sipeng , Li Lin , Wen Xuyang , Gu Xiang , Zhuang Ai , Li Rui , Ye Fuxiang , Ge Shengfang , Fan Xianqun , Fan Jiayan , Chai Peiwei , Lu Linna 
Published: May 2023

AbstractBackgroundThe precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis. Howbeit, the mechanism underlying the m5C modification in carcinogenesis remains to be fully addressed.MethodsGlobal and mRNA m5C levels were determined by mRNA isolation and anti‐m5C dot blot in both retinoblastoma (RB) cells and clinical samples. Orthotopic intraocular xenografts were established to examine the oncogenic behaviours of RB. Genome‐wide multiomics analyses were performed to identify the functional target of NSUN2, including proteomic analysis, transcriptome screening and m5C‐methylated RNA immunoprecipitation sequencing (m5C‐meRIP‐seq). Organoid‐based single‐cell analysis and gene‐correlation analysis were performed to verify the NSUN2/ALYREF/m5C‐PFAS oncogenic cascade.ResultsHerein, we report that NSUN2‐mediated m5C RNA methylation fuels purine biosynthesis during the oncogenic progression of RB. First, we discovered that global and mRNA m5C levels were significantly enriched in RBs compared to normal retinas. In addition, tumour‐specific NSUN2 expression was noted in RB samples and cell lines. Therapeutically, targeted correction of NSUN2 exhibited efficient therapeutic efficacy in RB both in vitro and in vivo. Through multiomics analyses, we subsequently identified phosphoribosylformylglycinamidine synthase (PFAS), a vital enzyme in purine biosynthesis, as a downstream candidate target of NSUN2. The reintroduction of PFAS largely reversed the inhibitory phenotypes in NSUN2‐deficient RB cells, indicating that PFAS was a functional downstream target of NSUN2. Mechanistically, we found that the m5C reader protein ALYREF was responsible for the recognition of the m5C modification of PFAS, increasing its expression by enhancing its RNA stability.ConclusionsConclusively, we initially demonstrated that NSUN2 is necessary for oncogenic gene activation in RB, expanding the current understanding of dynamic m5C function during tumour progression. As the NSUN2/ALYREF/m5C‐PFAS oncogenic cascade is an important RB trigger, our study suggests that a targeted m5C reprogramming therapeutic strategy may be a novel and efficient anti‐tumour therapy approach.
A multi‐omics perspective of CAR T cell therapy
Authors: Yang Jingwen , Chen Yamei , Han Leng 
Published: May 2023

AbstractAs omics technologies, including genomics, epigenomics, transcriptomics, T cell receptor‐repertorie profiling, proteomics, metabolomics and microbiomics, have provided valuable insights into CAR T cell therapy, in our recent review, we discuss these multidimensional profiling technologies in CAR T cell research, and their potential to identify tumor‐specific antigens and molecular characteristics associated with anti‐tumour effects and toxicities.
Meeting the challenges of educating internal evaluators
Authors: Lam Chi Yan , Kuji‐Shikatani Keiko , Love Arnold 
Published: May 2023

AbstractThe COVID‐19 pandemic and its related health, social, economic and geopolitical shocks have greatly increased the demand for internal evaluation as a way of helping organizations, especially those in the public sector, adapt to ongoing challenges and new realities. To help meet the demand, this chapter discusses the recent trend to educate managers, front‐line supervisors and other organization professionals to be nonspecialist internal evaluators—individuals who are not evaluation specialists. Three experienced internal evaluators and educators share real‐world examples of their successful strategies for educating nonspecialist internal evaluators. They conclude with a discussion of lessons learned and suggestions for the road ahead.
Setting the stage for critically defined and responsive evaluator education and training
Authors: LaVelle John M. , Neubauer Leah C. , Boyce Ayesha S. , Archibald Thomas 
Published: May 2023

AbstractThis chapter describes the importance of evaluator education and some of the different ways in which evaluators can learn about the field.It discusses a historic perspective on evaluator education alongside its recent developments, and describes areas where further discussion is needed, including critical adult education, universal design for learning, and explicitly linking evaluator education with contemporary and anticipated future needs. It concludes by asking “what should evaluator education look like in the future?”
Preparing the 21st century evaluator for language equity: Towards a language equity centered evaluation practice
Authors: Robles‐Schrader Grisel Marie , Lemos Diana 
Published: May 2023

AbstractClear and effective communication is a critical component of any evaluation design. An aspect of communication that is often overlooked is understanding a community's preferred language(s). This is a result of a power‐based system that operates under a dominant language and cultural structure. When language preferences are not appropriately addressed in evaluation design and implementation, the effect is the intentional or unintentional exclusion of groups of people affected by the very programs whose impact we seek to understand. This requires deeper engagement and continual commitment from evaluation teams to fully integrate language equity throughout an evaluation, from initial development to dissemination, to ensure activities maintain cultural equivalence and integrity surrounding language complexity. Authors propose actionable strategies evaluators can apply to assess and address language needs in evaluation design and implementation.
Building referral mechanisms for neonatal care in humanitarian emergency settings: A systematic review
Authors: Rutherford Spencer , Naman Maryan , Zaka Nabila , Michaux Kathryn , Cupp Meghan A. , Hafezi Hannah , Sami Samira , Alexander Emma C. , Lakhanpaul Monica , Manikam Logan 
Published: May 2023

AbstractAimDuring humanitarian emergencies, women and children are particularly vulnerable to health complications and neonatal mortality rates have been shown to rise. Additionally, health cluster partners face challenges in coordinating referrals, both between communities and camps to health facilities and across different levels of health facilities. The purpose of this review was to identify the primary referral needs of neonates during humanitarian emergencies, current gaps and barriers, and effective mechanisms for overcoming these barriers.MethodsA systematic review was performed using four electronic databases (CINAHL, EMBASE, Medline, and Scopus) between June and August 2019 (PROSPERO registration number CRD42019127705). Title, abstract, and full text screening were conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. The target population was neonates born during humanitarian emergencies. Studies from high‐income countries and prior to 1991 were excluded. The STROBE checklist was used to assess for risk of bias.ResultsA total of 11 articles were included in the analysis; these were mainly cross‐sectional, field‐based studies. The primary needs identified were referrals from homes to health facilities before and during labour, and inter‐facility referrals after labour to more specialised services. Some of the main barriers included a lack of roads and infrastructure for transport, staff shortages—especially among more specialised services, and a lack of knowledge among patients for self‐referral. Mechanisms for addressing these needs and gaps included providing training for community healthcare workers (CHWs) or traditional birth attendants to identify and address antenatal and post‐natal complications; education programmes for pregnant women during the antenatal period; and establishing ambulance services in partnership with local Non‐Governmental Organizations.ConclusionThis review benefited from a strong consensus among selected studies but was limited in the quality of data and types of data that were reported. Based on the above findings, the following recommendations were compiled:

Focus on local capacity‐building programmes to address programmes acutely.
Recruit CHWs to raise awareness of neonatal complications among pregnant women.
Upskill CHWs to provide timely, appropriate and quality care during humanitarian emergencies.
Environmental exposure and ecotoxicological properties of a new-generation fluorosurfactant (cC6O4): A comparison with selected legacy perfluoroalkyl acids
Authors: Bizzotto Elisa , Bonetto Alessandro , Marcomini Antonio , Vighi Marco 
Published: May 2023

Abstract
Cyclic C6O4 (cC6O4, CAS number 1190931-27-1) is a new-generation polyfluorinated alkyl substance (PFAS) used as a polymerization aid in the synthesis of fluoropolymers, which has been produced in Italy since 2011. A review of the properties of cC6O4, focused on environmental distribution and ecotoxicology, was conducted. The EQuilibrium Criterion model was applied, using default environmental scenarios, to estimate environmental distribution and fate. In a situation of static thermodynamic equilibrium in a closed system (Level I), cC6O4 distributes mainly to water (97.6%) and in a minimal amount to soil (2.3%). In a more realistic scenario (Level III), with dynamic conditions in an open system, with advection in air and water and with equal emissions in air and water, the major amount of the compound is transported through water advection. Monitoring data, mainly referring to surface and groundwater, are available for water bodies close to the production sites (maximum measured concentration 52 μg/L) as well as for a wider area in the river Po watershed with concentrations generally lower than 1 μg/L. Few values are also available for concentration in biota. Effect data indicate low toxicity on all tested organisms with no observed effect concentration (NOEC) values always higher than the maximum concentrations tested (100 mg/L for acute tests). Bioaccumulation potential is also very low. A comparison with selected widely used PFAS with five to eight C atoms indicates that cC6O4 is substantially less dangerous to aquatic organisms. For the time being, an ecological risk for the aquatic ecosystem may be excluded even in directly exposed ecosystems. However, for a complete assessment of the suitability of cC6O4 as a substitute for other PFAS (namely, perfluorooctanoic acid), more comprehensive chronic experiments are necessary, to produce realistic NOEC, as well as higher tier experiments (e.g., mesocosms) capable of providing ecologically relevant endpoints. Moreover, a more accurate evaluation of the environmental persistence would be necessary. Integr Environ Assess Manag 2023;19:1636–1648. © 2023 SETAC
Characterization of ovarian cancer survival by histotype and stage: A nationwide study in Norway
Authors: Fortner Renée Turzanski , Trewin‐Nybråten Cassia B. , Paulsen Torbjørn , Langseth Hilde 
Published: May 2023

AbstractContemporary population‐based data on ovarian cancer survival using current subtype classifications and by surgical status are sparse. We evaluated 1‐, 3‐, 5‐ and 7‐year relative (and overall) survival, and excess hazards in patients with borderline tumors or invasive epithelial ovarian cancer diagnosed 2012 to 2021 in a nationwide registry‐based cohort in Norway. Outcomes were evaluated by histotype, FIGO stage, cytoreduction surgery and residual disease. Overall survival was evaluated for non‐epithelial ovarian cancer. Survival of women with borderline ovarian tumors was excellent (≥98.0% 7‐year relative survival). Across all evaluated invasive epithelial ovarian cancer histotypes, 7‐year relative survival for cases diagnosed with stages I or II disease was ≥78.3% (stage II high‐grade serous). Survival for ovarian cancers diagnosed at stage ≥III differed substantially by histotype and time since diagnosis (eg, stage III, 5‐year relative survival from 27.7% [carcinosarcomas] to 76.2% [endometrioid]). Overall survival for non‐epithelial cases was good (91.8% 5‐year overall survival). Women diagnosed with stage III or IV invasive epithelial ovarian cancer and with residual disease following cytoreduction surgery had substantially better survival than women not operated. These findings were robust to restriction to women with high reported functional status scores. Patterns for overall survival were similar to those for relative survival. We observed relatively good survival with early stage at diagnosis even for the high grade serous histotype. Survival for patients diagnosed at stage ≥III invasive epithelial ovarian cancer was poor for all but endometrioid disease. There remains an urgent need for strategies for risk reduction and earlier detection, together with effective targeted treatments.
Successful spontaneous pregnancy after simultaneous kidney and pancreas transplant
Authors: Stanić Žana , Fureš Rajko , Vulić Marko , Čečuk Esma , Plazibat Milvija , Hrgović Zlatko , Cerovac Anis 
Published: May 2023

SynopsisGood and meticulous pre‐pregnancy follow up and a multidisciplinary approach is of crucial importance for a successful pregnancy outcome after pancreas and kidney transplantation.
Age‐related trajectory of bone density in children with intestinal failure: A longitudinal retrospective cohort study
Authors: Ali Farhana , Cole Conrad R. , Hornung Lindsey , Mouzaki Marialena , Wasserman Halley , Kalkwarf Heidi J. 
Published: May 2023

AbstractBackgroundLongitudinal changes in bone health in children with intestinal failure (IF) are unclear. We aimed to better understand the trajectory of bone mineral status over time in children with IF and identify clinical factors that influence the trajectory.MethodsClinical records of patients attending the Intestinal Rehabilitation Center of Cincinnati Children's Hospital Medical Center between 2012 and 2021 were reviewed. Children diagnosed with IF before age 3 years with at least two lumbar spine dual‐energy x‐ray absorptiometry scans were included. We abstracted information on medical history, parenteral nutrition, bone density, and growth. We calculated bone density z scores with and without adjustment for height z scores.ResultsThirty‐four children with IF met inclusion criteria. Children were shorter than average with a mean height z score of −1.5 ± 1.3. The mean bone density z score was −1.5 ± 1.3 with 25 of the cohort having a z score < −2.0. After height adjustment, the mean bone density z score was −0.42 ± 1.4 with 11% below −2.0. Most dual‐energy x‐ray absorptiometry scans (60%) had a feeding tube artifact. Bone density z scores increased slightly with age and lower parenteral nutrition dependency and were higher in scans without an artifact. Etiologies of IF, line infections, prematurity, and vitamin D status were not associated with height‐adjusted bone density z scores.ConclusionChildren with IF were shorter than expected for age. Deficits in bone mineral status were less common when adjusting for short stature. Etiologies of IF, prematurity, and vitamin D deficiency were not associated with bone density.
Managing allergic conjunctivitis via ophthalmic microemulsions: Formulation, characterization, in vitro irritation studies based onEpiOcular™ eye irritation assay and in vivo studies in rabbit eye
Authors: Yozgatlı Vildan , Üstündağ Okur Neslihan , Okur Mehmet Evren , Sipahi Hande , Charehsaz Mohammad , Aydın Ahmet , Uğurlu Timuçin 
Published: May 2023

AbstractThe purpose of this work was the development of an alternative ocular tetrahydrozoline hydrochloride (THZ) microemulsion for the management of allergic conjunctivitis. Pseudo‐ternary phase diagrams were used to produce the microemulsions. For the formulation of the microemulsions, isopropyl myristate was selected as oil. Furthermore, various surfactants were applied for the determination of their suitability; ME‐1 and ME‐4 were developed using Sorbitan monolaurate 80 and Polysorbate 80, for ME‐2 and ME‐5 Sorbitan monolaurate 80 and macrogolglycerol ricinoleate while for ME‐3 and ME‐6 Sorbitan monolaurate 80 and Polysorbate 20. For ME‐1, ME‐2, and ME‐3 propylene glycol and ethanol, for ME‐4, ME‐5, and ME‐6 ethanol and polyethylene glycol were used as co‐surfactants. Various characterization parameters of microemulsions were evaluated such as droplet size, conductivity, zeta potential, viscosity, and pH. In addition, the drug release, stability, sterility, safety, ex vivo, and in vivo experiments were studied. The characterization showed that the formulations can act as suitable carriers for eye application. In addition, it was revealed that microemulsions were found stable and sterile. The formulations released the drug in a sustained manner. Ex vivo diffusion studies exhibited that the microemulsions can be used for topical delivery to the eye. Assessment of in vitro ocular irritation was conducted by an in vivo prediction model, EpiOcular™ eye irritation test. Based on the in vivo studies, the chosen ideal microemulsion showed longer contact time to the cornea than the commercial product. Moreover, the developed ocular carrier was found to be safe from the viewpoint of in vitro ocular irritancy and mutagenicity. In conclusion, according to characterization results, the THZ microemulsions can act as a hopeful approach for topical eye application.