bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double “full moon” CTO plaque detected by computed tomography could predict high‐grade debulking techniques: A case‐report
Authors: Panuccio Giuseppe , Skurk Carsten , Landmesser Ulf , Abdelwahed Youssef S. 
Published: May 2023

Key Clinical MessageCircular heavily calcified “Full Moon” plaques relevance for CTO‐PCI remains unclear. This case shows a patient with double “Full Moon” plaques‐CTO. Cardiac tomography identified these lesions and allowed to provide adequate debulking equipment. “Full Moon” plaques could predict CTO‐PCI complexity. CT can identify these lesions and help planning CTO‐PCI for increasing success rates.
A case of acute encephalitis syndrome and cranial nerve palsy secondary to scrub typhus: A rare presentation from Western Nepal
Authors: Lamichhane Seshkanta , Achhami Eliz , Mahaju Satyam , Gautam Rabin , Adhikari Amrit 
Published: May 2023

Key Clinical MessageThis case report highlights the importance of considering scrub typhus as a differential diagnosis for acute encephalitis with cranial nerve palsy in the region of the tsutsugamushi triangle.AbstractScrub typhus is a zoonotic rickettsiosis caused by the bacterium Orientia tsutsugamushi. This disease is endemic to a region called the tsutsugamushi triangle that extends from Southeast Asia to the Pacific Ocean. We report a 17‐year‐old girl from western Nepal who presented with fever, headache, vomiting, and altered sensorium, as well as bilateral lateral rectus palsy, dysphagia, regurgitation of food, dysarthria, and left‐sided upper motor neuron type facial palsy. Following laboratory and imaging tests, the patient was diagnosed with scrub typhus and was treated successfully with high‐dose dexamethasone and doxycycline. This case highlights the importance of considering scrub typhus in the differential diagnosis of encephalitis with cranial nerve palsy, especially in the region of the tsutsugamushi triangle. It also emphasizes the need for timely diagnosis and treatment of scrub typhus to prevent the development of various complications and ensure earlier recovery of patients.
Organizing pneumonia as an initial presentation in a male lupus: A rare case report
Authors: Acharya Suman , Aryal Roshan , Yadav Rupesh Kumar , Shrestha Suraj , Karki Rikesh , Jha Saket 
Published: May 2023

AbstractOrganizing pneumonia (OP) is one of the rare pulmonary manifestations of systemic lupus erythematosus (SLE) which is infrequently reported as a presenting manifestation. Early diagnosis of lupus‐related OP with the help of imaging, can drive to prompt initiation of immunosuppressive therapy leading to a better prognosis. We present a case of a 34‐year‐old young male who presented with fever, myalgia, and a dry cough for 1 month and was later diagnosed as SLE‐related organizing pneumonia.
Effect of Carbonization Behaviour of Cotton Biomass in Electrodes for Sodium‐Ion Batteries
Authors: Sarma Hridip Ranjan , Sun Ju , Hora Yvonne , Forsyth Maria , Byrne Nolene 
Published: May 2023

AbstractFree‐standing hard carbon electrodes are produced from cotton biomass using a low‐cost, one‐step pathway. The free‐standing feature of the electrode eliminates the use of binders and toxic solvents. The electrochemical performance of the electrodes is tested to study the correlation between Na storage and the structural properties of the hard carbon material. A remarkable specific capacity of 272 mAh g−1 at a current density of 50 mA g−1 is obtained with a high initial Coulombic efficiency of 75 % for the cotton fabric (CF) sample pyrolyzed at 1000 °C for 5 min (CF5 min). The excellent performance of the free‐standing electrode is attributed to a large interlayer spacing between the graphene layers, and a high number of oxygen‐containing functional groups on the surface. X‐ray photoelectron spectroscopy (XPS) surface characterisation shows that a thin and uniformly distributed SEI (solid electrolyte interphase) layer, mainly composed of NaF and Na2O, is formed on the CF5 min surface, whereas a thick SEI layer with a long Na+ diffusion pathway is formed on the sample pyrolyzed at 1000 °C for 10 h (CF10 h), which leads to slower reaction kinetics and poor electrochemical performance. This work proposes a scalable and economically feasible strategy to produce sodium ion anode materials with a focus on environmental sustainability and value addition to waste streams.
Oxygen functionalization‐assisted anionic exchange toward unique construction of flower‐like transition metal chalcogenide embedded carbon fabric for ultra‐long life flexible energy storage and conversion
Authors: Bhattarai Roshan M. , Chhetri Kisan , Le Nghia , Acharya Debendra , Saud Shirjana , Nguyen Mai Cao Hoang Phuong Lan , Kim Sang Jae , Mok Young Sun 
Published: May 2023

AbstractThe metal‐organic framework (MOF) derived Ni–Co–C–N composite alloys (NiCCZ) were “embedded” inside the carbon cloth (CC) strands as opposed to the popular idea of growing them upward to realize ultrastable energy storage and conversion application. The NiCCZ was then oxygen functionalized, facilitating the next step of stoichiometric sulfur anion diffusion during hydrothermal sulfurization, generating a flower‐like metal hydroxysulfide structure (NiCCZOS) with strong partial implantation inside CC. Thus obtained NiCCZOS shows an excellent capacity when tested as a supercapacitor electrode in a three‐electrode configuration. Moreover, when paired with the biomass‐derived nitrogen‐rich activated carbon, the asymmetric supercapacitor device shows almost 100% capacity retention even after 45,000 charge–discharge cycles with remarkable energy density (59.4 Wh kg–1/263.8 µWh cm–2) owing to a uniquely designed cathode. Furthermore, the same electrode performed as an excellent bifunctional water‐splitting electrocatalyst with an overpotential of 271 mV for oxygen evolution reaction (OER) and 168.4 mV for hydrogen evolution reaction (HER) at 10 mA cm−2 current density along with 30 h of unhinged chronopotentiometric stability performance for both HER and OER. Hence, a unique metal chalcogenide composite electrode/substrate configuration has been proposed as a highly stable electrode material for flexible energy storage and conversion applications.
Effect of the oxidation of activated carbon by hydrogen peroxide on its catalytic activity in the regeneration of Co(II)TETA
Authors: Li Zi‐Qiu , Chen Pei‐Yun , Long Xiang‐Li 
Published: May 2023

AbstractCobalt(II) triethylenetetramine (Co(II)TETA) formed by soluble cobalt(II) salt combining with triethylenetetramine will be used as a wet denitration technique since it can interact with nitric oxide to accomplish quick absorption of NO from gas phase. However, the oxygen in the flue gas will oxidize Co(II)TETA to Co(III) TETA, resulting in the reduction of denitrification efficiency. Activated carbon has been used to promote the regeneration of Co(II)TETA due to its unique surface characteristics. Hydrogen peroxide solution is utilized as a modifier in the carbon modification to improve the catalytic performance of activated carbon. The experiments demonstrate that the best regeneration efficiency of Co(II)TETA is gained by the modified carbon impregnated in 0.05 mol L−1 H2O2 solution at 70°C for 12 h with a solid/liquid ratio of 1/50 (g/mL) followed being activated at 400°C for 2 h in N2. After being treated with hydrogen oxide solution, the surface area and acidity of the carbon is increased. Continuous experiments reveal that the NO removal efficiency gained by modified activated carbon is about 8.36% higher than that gained by the original carbon.
Fractional‐order poromechanics for a fully saturated biological tissue: Biomechanics of meniscus
Authors: Amiri Fabiana , Bologna Emanuela , Nuzzo Gianmarco , Moroni Lorenzo , Zingales Massimiliano 
Published: May 2023

AbstractBiomechanics of biological fibrous tissues as the meniscus are strongly influenced by past histories of strains involving the so‐called material hereditariness. In this paper, a three‐axial model of linear hereditariness that makes use of fractional‐order calculus is used to describe the constitutive behavior of the tissue. Fluid flow across meniscus' pores is modeled in this paper with Darcy relation yielding a novel model of fractional‐order poromechanics, describing the evolution of the diffusion phenomenon in the meniscus. A numerical application involving an 1D confined compression test is reported to show the effect of the material hereditariness on the pressure drop evolution.
Feature selection‐integrated classifier optimisation algorithm for network intrusion detection
Authors: Güney Hüseyin 
Published: May 2023

SummaryIn the era of technology, information security has gained significant importance, as intruders constantly conduct attacks to breach information systems. Intelligent network intrusion detection systems (NIDS) are promising for detecting malicious activities; however, it is required to apply feature selection (FS) and classifier optimisation (CO) using cost‐effective algorithms to build an accurate and efficient system. Although classifier‐dependent FS (CDFS) techniques and CO algorithms have been shown to perform well, they suffer from computational complexity, and their interdependencies negatively affect model performance. This study proposes the FS‐integrated classifier optimisation algorithm that incorporates FS during CO, enhances optimisation, and tackles the interdependency problem. Furthermore, since this algorithm does not use an iterative feature selection process, such as forward selection or backward elimination, it provides relatively less complexity than other CDFS techniques. Moreover, an application of the proposed methodology (NIDS) was implemented using the designed framework to validate the model in this problem domain. The proposed methodology achieved accuracies of 85.10%, 73.24% with one feature for the NSLKDD datasets, 83.45% with 32 features for the UNSW‐NB15 dataset, 99.41% with eight features, and 99.63% with 16 features for the CIC‐IDS2017 datasets. The results showed that the FS‐integrated optimisation algorithm had improved the accuracy of the classifier with fewer features. Furthermore, the proposed methodology outperformed other FS, ensemble learning, and deep learning‐based methods regarding detection accuracy and false alarm rate. In conclusion, the developed NIDS is an accurate, efficient, straightforward, feasible, and easy‐to‐implement system that can be created using limited computing power and time as a promising solution to protect traditional and modern computer networks.
Aqueous Redox Flow Batteries: Small Organic Molecules for the Positive Electrolyte Species
Authors: Cannon Christopher G. , Klusener Peter A. A. , Brandon Nigel P. , Kucernak Anthony R. J. 
Published: May 2023

AbstractThere are a number of critical requirements for electrolytes in aqueous redox flow batteries. This paper reviews organic molecules that have been used as the redox‐active electrolyte for the positive cell reaction in aqueous redox flow batteries. These organic compounds are centred around different organic redox‐active moieties such as the aminoxyl radical (TEMPO and N‐hydroxyphthalimide), carbonyl (quinones and biphenols), amine (e. g., indigo carmine), ether and thioether (e. g., thianthrene) groups. We consider the key metrics that can be used to assess their performance: redox potential, operating pH, solubility, redox kinetics, diffusivity, stability, and cost. We develop a new figure of merit – the theoretical intrinsic power density – which combines the first four of the aforementioned metrics to allow ranking of different redox couples on just one side of the battery. The organic electrolytes show theoretical intrinsic power densities which are 2–100 times larger than that of the VO2+/VO2+ couple, with TEMPO‐derivatives showing the highest performance. Finally, we survey organic positive electrolytes in the literature on the basis of their redox‐active moieties and the aforementioned figure of merit.
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner
Authors: Shen Dingcheng , Lin Jinxin , Xie Yumo , Zhuang Zhuokai , Xu Gaopo , Peng Shaoyong , Tang Guannan , Bai Liangliang , Zhu Mingxuan , Zhang Yu , Huang Ziying , Wang Puning , Liu Xiaoxia , Huang Meijin , Luo Yanxin , Wang Xiaolin , Yu Huichuan 
Published: May 2023

AbstractBackgroundN6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a well‐described m6A demethylase in previous enzyme assays, we aimed to investigate the role of m6A methylation alteration conferred by disturbed ALKBH5 in colorectal cancer (CRC) development.MethodsExpression of ALKBH5 and its correlation with clinicopathological characteristics of CRC were evaluated using the prospectively maintained institutional database. The molecular role and underlying mechanism of ALKBH5 in CRC were explored using in vitro and in vivo experiments with methylated RNA immunoprecipitation sequencing (MeRIP‐seq), RNA‐seq, MeRIP‐qPCR, RIP‐qPCR and luciferase reporter assays.ResultsALKBH5 expression was significantly upregulated in CRC tissues compared to the paired adjacent normal tissues, and higher expression of ALKBH5 was independently associated with worse overall survival in CRC patients. Functionally, ALKBH5 promoted the proliferative, migrative and invasive abilities of CRC cells in vitro and enhanced subcutaneous tumour growth in vivo. Mechanistically, RAB5A was identified as the downstream target of ALKBH5 in CRC development, and ALKBH5 posttranscriptionally activated RAB5A by m6A demethylation, which impeded the YTHDF2‐mediated degradation of RAB5A mRNA. In addition, we demonstrated that dysregulation of the ALKBH5‐RAB5A axis could affect the tumourigenicity of CRC.ConclusionsALKBH5 facilitates the progression of CRC by augmenting the expression of RAB5A via an m6A‐YTHDF2‐dependent manner. Our findings suggested that ALKBH5‐RAB5A axis might serve as valuable biomarkers and effective therapeutic targets for CRC.
Three‐dimensional scan‐based algorithm for directional neighbor discovery in ad hoc networks
Authors: Lan Haiwen , Liu Gang , Wang Wei , Liang Chengchao , Ma Zheng 
Published: May 2023

SummaryIn recent years, neighbor discovery techniques using directional antennas have attracted widespread attention. Most currently available directional neighbor discovery techniques are designed based on two‐dimensional (2D) space. Although these algorithms can accomplish the discovery between nodes, the algorithm portability is poor for three‐dimensional (3D) platforms, and the application scenarios are limited since new communication scenarios such as unmanned aerial vehicle (UAV) groups and maritime fleets emerge where information needs to be delivered in real time and nodes are located in 3D space. This paper proposes a new deterministic directional neighbor discovery algorithm in 3D space named 3D scan‐based algorithm (3D‐SBA) to meet the needs of the line‐of‐sight (LOS) scenes. Four existing neighbor discovery algorithms, namely, SBA‐based random mode selection (SBA‐R), quorum, complete random algorithm (CRA), and SBA‐based leader election algorithm (LE), have been extended to our proposed 3D algorithm model for simulation and comparative analysis with 3D‐SBA. The simulation results show that the 3D‐SBA algorithm consumes 51.15%, 180.20%, 9.48%, and 17.49% of the time slots compared with the four existing algorithms mentioned above. However, the quorum algorithm has a very high node collision rate, up to 92.11%. Ultimately, the 3D‐SBA algorithm has the best performance considering the conflicts and the density of network nodes.
Genetic characterization of C. elegansTMED genes
Authors: Navarro Kristen G. , Chamberlin Helen M. 
Published: May 2023

AbstractBackgroundp24/transmembrane Emp24 domain (TMED) proteins are a set of evolutionarily conserved, single pass transmembrane proteins that have been shown to facilitate protein secretion and selection of cargo proteins to transport vesicles in the cellular secretion pathway. However, their functions in animal development are incompletely understood.ResultsThe C. elegans genome encodes eight identified TMED genes, with at least one member from each defined subfamily (α, β, γ, δ). TMED gene mutants exhibit a shared set of defects in embryonic viability, animal movement, and vulval morphology. Two γ subfamily genes, tmed‐1 and tmed‐3, exhibit the ability to compensate for each other, as defects in movement and vulva morphology are only apparent in double mutants. TMED mutants also exhibit a delay in breakdown of basement membrane during vulva development.ConclusionsThe results establish a genetic and experimental framework for the study of TMED gene function in C. elegans, and argue that a functional protein from each subfamily is important for a shared set of developmental processes. A specific function for TMED genes is to facilitate breakdown of the basement membrane between the somatic gonad and vulval epithelial cells, suggesting a role for TMED proteins in tissue reorganization during animal development.
Influence of ambient temperature on the phenology of the greater mouse‐eared bat (Myotis myotis)
Authors: Matthäus Laura , Kugelschafter Karl , Fietz Joanna 
Published: May 2023

AbstractIn order to assess the consequences of climate change and evaluate its impacts on wildlife, it is essential to do so on a species‐specific level. It is assumed that changes in the ambient temperature influence energy consumption as well as food availability and thus foraging behavior, reproduction, survival, and therefore population dynamics in bats. Based on this assumption, the present study aims to gain insights into the roosting and breeding behavior of the greater mouse‐eared bat (Myotis myotis) in relation to changes of the ambient temperature. For this purpose, we investigated the effect of ambient temperature on the phenology of the greater mouse‐eared bat by using activity data of the bats collected using light barriers at the maternity roosts. The light barrier used in this study is a system that detects the interruption of two light beams, for example, by a flying bat, and displays it as an electrical signal.The investigations have shown that

the higher the winter temperatures, the earlier the greater mouse‐eared bats returned to the roosts to form the maternity colony; however, this was only true for ambient temperatures below 0.5°C,
birth season started earlier at higher spring temperatures,
the dissolution of maternity roosts occurred earlier with earlier birth season and at higher ambient temperatures during lactation.
The results revealed that ambient temperature has an influence on the phenology of the greater mouse‐eared bat. Depending on the respective life history stage, an increase in ambient temperature can have a positive or negative effect on the fitness of the animals. In recent years, mild winters have been recorded more frequently, which can have an influence on the behavior of bats. Warm winters within certain limits seem to lead to an earlier formation of the maternity colony, which can be positive or negative for the bats depending on persistent weather conditions and thus insect availability. In the course of climate change, we can also expect earlier spring events and an increase in spring temperature, as well as hot spells in summer. These warm springs and summers seem to lead to an earlier beginning of births, a faster development of the juveniles and an earlier dissolution of the maternity roost. An advance of reproductive activities can be assumed to increase the chance to survive the following winter in both mothers and their young, as they have more time to build up sufficient energy reserves for hibernation before winter starts. Due to the climatic changes, phenological changes of the bats be expected. This study highlights that in order to understand the impact of climate change on biodiversity, it is necessary to investigate in detail effects on a species‐specific level and also to consider direct and indirect effects of ambient temperature on different life history stages.
Maternal and infantile gut mycobiome during the weaning period in free ranging Tibetan macaques (Macaca thibetana)
Authors: Yue Ran , Chen Huijuan , Xu Xiaojuan , Xia Yingna , Sun Yu , Xia Mengyi , Xia Dongpo , Sun Binghua 
Published: May 2023

AbstractGut microbiome is critical to the health of mammals. Many previous studies have revealed the gut bacterial microbiomes of mother and infant changed significantly during the weaning period. However, little is known concerning the gut mycobiome of wild primates. Here, we examined the variations on gut mycobiome between weaning and post‐weaning for both mother and infant in wild‐living Tibetan macaques (Macaca thibetana). Our results showed that the gut mycobiomes of mother and infant were dominated by two phyla Ascomycota and Basidiomycota. For both mother and infant, the ASV richness of gut mycobiome remained relatively steady from weaning to post‐weaning periods, while the Shannon indexes increased significant in weaning compared to post‐weaning periods. However, no significant difference between mother and infant ASV richness and Shannon indexes during weaning and post‐weaning periods respectively. Compared to mothers, we found that much more known taxa of gut fungi were enriched in weaning or post‐weaning periods of infants. In particular, we found that the dominant genus Aspergillus was enriched in infants during weaning period. Furthermore, we found that the relative abundance of plant pathogens were significantly higher in the post‐weaning period than in the weaning period for infants. Our results indicated that weaning events could affect the gut mycobiome significantly for both mothers and infant in Tibetan macaques, which had a stronger effect on the gut mycobiome of infant monkeys than on their mothers.
Food webs coupled in space: Consumer foraging movement affects both stocks and fluxes
Authors: Wootton Kate L. , Curtsdotter Alva , Bommarco Riccardo , Roslin Tomas , Jonsson Tomas 
Published: May 2023

AbstractThe exchange of material and individuals between neighboring food webs is ubiquitous and affects ecosystem functioning. Here, we explore animal foraging movement between adjacent, heterogeneous habitats and its effect on a suite of interconnected ecosystem functions. Combining dynamic food web models with nutrient‐recycling models, we study foraging across habitats that differ in fertility and plant diversity. We found that net foraging movement flowed from high to low fertility or high to low diversity and boosted stocks and flows across the whole loop of ecosystem functions, including biomass, detritus, and nutrients, in the recipient habitat. Contrary to common assumptions, however, the largest flows were often between the highest and intermediate fertility habitats rather than highest and lowest. The effect of consumer influx on ecosystem functions was similar to the effect of increasing fertility. Unlike fertility, however, consumer influx caused a shift toward highly predator‐dominated biomass distributions, especially in habitats that were unable to support predators in the absence of consumer foraging. This shift resulted from both direct and indirect effects propagated through the interconnected ecosystem functions. Only by considering both stocks and fluxes across the whole loop of ecosystem functions do we uncover the mechanisms driving our results. In conclusion, the outcome of animal foraging movements will differ from that of dispersal and diffusion. Together we show how considering active types of animal movement and the interconnectedness of ecosystem functions can aid our understanding of the patchy landscapes of the Anthropocene.