bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salicylic acid promotes terpenoid synthesis in the fungi Sanghuangporus baumii
Authors: Wang Xutong , Sun Jian , Wang Shixin , Sun Tingting , Zou Li 
Published: April 2023

AbstractSanghuangporus baumii is a medicinal fungi with anti‐inflammatory, liver protection and antitumour effects. Terpenoids are one of the main medicinal ingredients of S. baumii. However, terpenoid production by wild‐type S. baumii cannot meet the market demand, which affects its application in medical care. Therefore, exploring how to increase terpenoid content in S. baumii is a promising path in this research field. Salicylic acid (SA) is a secondary metabolite. In this study, a concentration of 350 μmol/L SA was added into fungal cultivations for 2 and 4 days, and then the transcriptome and metabolome of untreated mycelia and treated with SA were analysed. The expression of some genes in the terpenoids biosynthesis pathway increased in SA‐induced cultivations, and the content of isopentenyl pyrophosphate (IPP) and geranylgeranyl‐PP (GGPP) increased significantly as well as the contents of triterpenoids, diterpenoids, sesquiterpenoids and carotenoids. The gene FPS was considered to be a key gene regulating terpenoid biosynthesis. Therefore, FPS was overexpressed in S. baumii by Agrobacterium tumefaciens‐mediated genetic transformation. The gene FPS and its downstream gene (LS) expression levels were confirmed to be increased in the FPS overexpressing transformant, and terpenoid content was 36.98% higher than that of the wild‐type strain in the evaluated cultivation conditions.
Climate action for health: Inter‐regional engagement to share knowledge to guide mitigation and adaptation actions
Authors: Fears Robin , Canales‐Holzeis Claudia , Caussy Deoraj , Harper Sherilee L. , Hoe Victor Chee Wai , McNeil Jeremy N. , Mogwitz Johanna , ter Meulen Volker , Haines Andy 
Published: April 2023

AbstractClimate change, attributable to human activity, is increasingly contributing to a global health crisis. The scale, nature and timing of adverse effects on physical and mental health, via direct and indirect pathways, vary within and between regions but there are common challenges that can be tackled by better integrated mitigation and adaptation actions. The actions described in this paper would have benefits for health if appropriately implemented, both by reducing the health risks of climate change and from the ancillary (co‐)benefits of mitigation such as from reduced air pollution as a result of phasing out fossil fuels. There are unprecedented health threats from climate change but also unprecedented opportunities to use scientific knowledge to inform policy and practice. Much can be done now to use the evidence already available to effect rapid and decisive action as well as generating new evidence to support effective policy development and implementation. This paper draws on an inter‐regional, inclusive, project by the InterAcademy Partnership, the global network of more than 140 academies of science, engineering and medicine, to summarise evidence available worldwide in order to help inform options for policy making. A particular focus is on clarifying climate change mitigation and adaptation solutions and their implementation for the benefit of the most vulnerable groups. The present authors actively participated in managing this project which encouraged academies to capture diverse impacts and policy options by evaluating and synthesising evidence from their own countries to inform policy for collective and customised action at national, regional and global levels. Using a systems‐based approach, recommendations from the project in this publication are transdisciplinary and multisectoral. Despite the accumulating evidence, protecting and improving human health have not yet become major focal points in global climate change policy discussions. Drawing on the IAP project outputs, we strongly recommend that health and health equity must now come to the foreground, accompanied by much greater allocation of climate finance to health‐related programmes.
Writing a massively multi‐authored paper: Overcoming barriers to meaningful authorship for all
Authors: Borer Elizabeth T. , MacDougall Andrew S. , Stevens Carly J. , Sullivan Lauren L. , Wilfahrt Peter A. , Seabloom Eric W. 
Published: April 2023

Abstract

The value of large‐scale collaborations for solving complex problems is widely recognized, but many barriers hinder meaningful authorship for all on the resulting multi‐author publications. Because many professional benefits arise from authorship, much of the literature on this topic has focused on cheating, conflict and effort documentation. However, approaches specifically recognizing and creatively overcoming barriers to meaningful authorship have received little attention.

We have developed an inclusive authorship approach arising from 15 years of experience coordinating the publication of over 100 papers arising from a long‐term, international collaboration of hundreds of scientists.

This method of sharing a paper initially as a storyboard with clear expectations, assignments and deadlines fosters communication and creates unambiguous opportunities for all authors to contribute intellectually. By documenting contributions through this multi‐step process, this approach ensures meaningful engagement by each author listed on a publication.

The perception that co‐authors on large authorship publications have not meaningfully contributed underlies widespread institutional bias against multi‐authored papers, disincentivizing large collaborations despite their widely recognized value for advancing knowledge. Our approach identifies and overcomes key barriers to meaningful contributions, protecting the value of authorship even on massively multi‐authored publications.
The Netherlands: Political Developments and Data in 2022
Authors: OTJES SIMON , DE JONGE LÉONIE 
Published: April 2023

AbstractThe
year 2022 was a period of contradictory developments in terms of political stability in the Netherlands. On the one hand, Mark Rutte became the longest‐serving Prime Minister in the country's history after celebrating his 12th year in office. On the other hand, the newly formed Rutte IV Cabinet was charged with steering the country through a tumultuous period, marked by soaring energy prices and inflation in the wake of the Russian invasion of Ukraine, large‐scale civil unrest in response to the government's plans to cut nitrogen emissions, and a political crisis over the housing of asylum seekers.
Association of sleep and anaesthesia EEG biomarkers with preoperative MoCA score: A pilot study
Authors: Touchard Cyril , Guimard Pauline , Guessous Karim , Aubin Oriane Saint , Levé Charlotte , Joachim Jona , Elayeb Kenza , Mebazaa Alexandre , Gayat Étienne , Mateo Joaquim , Vallée Fabrice , Cartailler Jérôme 
Published: April 2023

AbstractIntroductionPreoperative cognitive impairments increase the risk of postoperative complications. The electroencephalogram (EEG) could provide information on cognitive vulnerability. The feasibility and clinical relevance of sleep EEG (EEGsleep) compared to intraoperative EEG (EEGintraop) in cognitive risk stratification remains to be explored. We investigated similarities between EEGsleep and EEGintraop vis‐a‐vis preoperative cognitive impairments.MethodsPilot study including 27 patients (63 year old [53.5, 70.0]) to whom Montreal cognitive assessment (MoCA) and EEGsleep were administered 1 day before a propofol‐based general anaesthesia, in addition to EEGintraop acquisition from depth‐of‐anaesthesia monitors. Sleep spindles on EEGsleep and intraoperative alpha‐band power on EEGintraop were particularly explored.ResultsIn total, 11 (41%) patients had a MoCA <25 points. These patients had a significantly lower sleep spindle power on EEGsleep (25 vs. 40 μv2/Hz, p = .035) and had a weaker intraoperative alpha‐band power on EEGintraop (85 vs. 150 μv2/Hz, p = .001) compared to patients with normal MoCA. Correlation between sleep spindle and intraoperative alpha‐band power was positive and significant (r = 0.544, p = .003).ConclusionPreoperative cognitive impairment appears to be detectable by both EEGsleep and EEGintraop. Preoperative sleep EEG to assess perioperative cognitive risk is feasible but more data are needed to demonstrate its benefit compared to intraoperative EEG.
Association of pharmacological treatments and real‐world outcomes in borderline personality disorder
Authors: Lieslehto Johannes , Tiihonen Jari , Lähteenvuo Markku , Mittendorfer‐Rutz Ellenor , Tanskanen Antti , Taipale Heidi 
Published: April 2023

AbstractObjectiveMost patients with borderline personality disorder (BPD) receive psychopharmacological treatment, but clinical guidelines on BPD lack consensus on the role of pharmacotherapy. We investigated the comparative effectiveness of pharmacological treatments for BPD.MethodsWe identified patients with BPD with treatment contact during 2006–2018 using Swedish nationwide register databases. By leveraging within‐individual design, in which each individual was used as their own control to eliminate selection bias, we assessed the comparative effectiveness of pharmacotherapies. For each medication, we calculated the hazard ratios (HRs) for the following outcomes: (1) psychiatric hospitalization and (2) hospitalization owing to any cause or death.ResultsWe identified 17,532 patients with BPD (2649 men; mean [SD] age = 29.8 [9.9]). Treatment with benzodiazepines (HR = 1.38, 95% CI = 1.32–1.43), antipsychotics (HR = 1.19, 95% CI = 1.14–124), and antidepressants (HR = 1.18, 95% CI = 1.13–1.23) associated with increased risk of psychiatric rehospitalization. Similarly, treatment with benzodiazepines (HR = 1.37, 95% CI = 1.33–1.42), antipsychotics (HR = 1.21, 95% CI = 1.17–1.26), and antidepressants (HR = 1.17, 95% CI = 1.14–1.21) was associated with a higher risk of all‐cause hospitalization or death. Treatment with mood stabilizers did not have statistically significant associations with the outcomes. Treatment with ADHD medication was associated with decreased risk of psychiatric hospitalization (HR = 0.88, 95% CI = 0.83–0.94) and decreased risk of all‐cause hospitalization or death (HR = 0.86, 95% CI = 0.82–0.91). Of the specific pharmacotherapies, clozapine (HR = 0.54, 95% CI = 0.32–0.91), lisdexamphetamine (HR = 0.79, 95% CI = 0.69–0.91), bupropion (HR = 0.84, 95% CI = 0.74–0.96), and methylphenidate (HR = 0.90, 95% CI = 0.84–0.96) associated with decreased risk of psychiatric rehospitalization.ConclusionsADHD medications were associated with a reduced risk of psychiatric rehospitalization or hospitalization owing to any cause or death among individuals with BPD. No such associations were found for benzodiazepines, antidepressants, antipsychotics, or mood stabilizers.
Comparative localization of the courses of superficial veins in rabbits' limbs using latex and VeinViewer systems
Authors: Karaavci Funda Aksunger , Karan Meryem 
Published: April 2023

AbstractThe purpose of this study; It is to reveal whether the veinviewer device, which we have not encountered in animals, can be visualized in rabbits for thoracic and pelvic limb superficial veins. Therefore, the latex method was used as a “gold test” to verify VeinViewer precision. For this purpose, the project was designed with two stages. In the first stage, the extremities of 15 New Zealand white rabbits were imaged using the VeinViewer device, and the results were recorded. In the second stage, the latex injection method was applied to the same animals, the cadavers were dissected, and the obtained results were comparatively analysed. In the rabbits, it was determined that v. cephalica originated from v. jugularis or v. brachialis in the proximity of the insertion of m. omotransversarius and anastomosed with v. mediana at the middle 1/3 level of the antebrachium. It was found that the superficial venous circulation of the pelvic limbs was provided by the branches of v. iliaca externa and v. iliaca interna. The vena saphena medialis was determined to be present in pairs in 80% of the cadavers. All cadavers showed the presence of the ramus anastomoticus cum vena saphena mediali. Additionally, the superficial veins of both the thoracic limbs and pelvic limbs of the rabbits were imaged with the VeinViewer device, which provided results parallel with the results of the latex injection method. Considering that the findings obtained with the latex injection method and the VeinViewer device were compatible, the usage of this device can potentially be considered as an alternative to visualizing superficial veins in animals. Further morphological and clinical studies can prove that the method is applicable.
Review of long‐term complications and functional outcomes of ileoanal pouch procedures in patients with inflammatory bowel disease
Authors: Hassan Yusuf , Connell William R. , Rawal Alisha , Wright Emily K. 
Published: April 2023

AbstractBackgroundIn medically refractory Ulcerative Colitis (UC), proctocolectomy with ileoanal pouch procedure (IAPP) is the preferred continence‐preserving surgical option. Functional outcomes post‐surgery and long‐term complication rates in the biologic era remain ambiguous. This review primarily aims to provide an update on these outcomes. Secondarily, risk factors associated with chronic pouchitis and pouch failure are explored.MethodsTwo online databases (MEDLINE and EMBASE) were searched on 4 October 2022 for English studies from 2011‐present relating to long‐term outcomes of IAPP in inflammatory bowel disease (IBD) patients. Adult patients with 12 month follow‐up were included. Studies focused on 30‐day post‐operative outcomes, non‐IBD patients or studies including less than 30 patients were excluded.ResultsFollowing screening and full‐text review of 1094 studies, 49 were included. Median sample size was n = 282 (IQR: 116–519). Median incidences for chronic pouchitis and pouch failure were 17.1% (IQR: 12–23.6%) and 6.9% (IQR: 4.8–10.8%), respectively. Upon multivariate analysis, chronic pouchitis development was most significantly associated with pre‐operative steroid use, pancolitis and extra‐intestinal IBD manifestations, whilst pouch failure was most significantly associated with pre‐operative diagnosis of Crohn's disease (compared to UC), peri‐operative pelvic sepsis and anastomotic leak. Overall patient satisfaction was very high with four included studies reporting greater than 90% satisfaction rates.ConclusionLong‐term complications for IAPP were common. However, despite this, patient satisfaction post‐IAPP was high. Up‐to‐date knowledge of complication rates and their risk factors improves pre‐operative counselling, management planning and patient outcomes.
How to facilitate concurrent lower lobectomy after coronary artery bypass grafting via median sternotomy without adding anterolateral thoracotomy?
Authors: Seyrek Yunus , Akkuş Murat 
Published: April 2023

AbstractBackground and aimMedian sternotomy is an unfavourable approach for performing lung resection and mediastinal lymphadenectomy. Some studies have speculated that concurrent pulmonary resections other than upper lobectomy, necessitate anterolateral thoracotomy in addition to sternotomy. In this study, we aimed to discuss the feasibility and advantages of concomitant video‐thoracoscopy (VATS) assisted lower lobectomy after coronary artery bypass grafting (CABG).MethodsWe analysed 21 patients who underwent a single combined procedure that includes CABG followed by anatomical pulmonary resection and divided them into two groups: patients who underwent upper lobectomy via median sternotomy incision (Group A, n = 12) and patients who underwent lower lobectomy with video‐thoracoscopic assistance (VATS) next to sternotomy incision (Group B, n = 9).ResultsThere were no significant differences between the groups in age, sex, comorbidities, tumour side or size, tumour stage, tumour histopathology, number of dissected lymph node stations, N status, CABG type, number of grafts used, operative time, hospitalization and complication rates.ConclusionThe feasibility of upper lobectomies via median sternotomy is clear; however, performing lower lobectomies is challenging. In our study, we concluded that the operative feasibility of concurrent lower lobectomy by VATS assistance showed no essential difference to that of concurrent upper lobectomy by presenting that there was no statistically significant difference between the groups in terms of any studied parameters. We can speculate that median sternotomy with VATS assistance should be especially considered instead of anterolateral thoracotomy for lower lobectomies at centres where VATS lobectomies are performed.
Feeling/thinking the archive: Participatory mapping Marronage
Authors: Zavala Guillen Ana Laura 
Published: April 2023

AbstractThis article develops a decolonial participatory method to map the geographies of descendants of fugitives from slavery, or Maroons, to disrupt white‐Mestizo constructions of Latin American territories. Maroon‐descendant communities can take advantage of existing archives and their extensive oral history to explain their territorial development from a home‐grown perspective. With the researcher's assistance, members of San Basilio de Palenque, Colombia, used their knowledge and emotions as a lens through which to analyse colonial records to map their territory from both a historical and present day perspective. Feeling/thinking about dispossession and resistance while counter‐using the colonial archive to reclaim Afro‐descendant territory is a subversive undertaking, one that is engrained in the legacy of Maroon resistance.
An exploration of the ideological becoming of online educators
Authors: Larty Joanne , Hodgson Vivien 
Published: April 2023

AbstractAs online education continues to proliferate that there is a need to understand how institutions can better support faculty in the transition to online education. Building on work that has suggested the importance of learning spaces for faculty to engage in discussion and reflection on their move to online education, this paper employs Bakhtin's notion of ideological becoming to provide a theoretically grounded understanding of how the design of such spaces can better facilitate this move. The paper reveals how learning spaces designed to develop critical awareness empower faculty to navigate discourses of online education, enabling them to build on their existing knowledge and skills as educators. The findings reveal how engaging faculty in critical dialogue can enable a cumulative shift in thinking from discussions dominated by authoritative discourses of online education that create an initial confusion between performance and pedagogy to the development of critical awareness that enables them to challenge dominant discourses and reconnect with the self as an experienced educator. The paper provides an important insight into an approach that might enable institutions to better support faculty buy‐in and acceptance of online education.
Practitioner NotesWhat is already known about this topic

Institutions struggle to understand how best to engage faculty in the transition to online education.

A number of frameworks and models have been proposed to facilitate the transition, but these mostly take a managerial perspective.

The transition to online teaching is most effective when supported by opportunities for faculty to engage in critical reflection and discussion.

Less is known about how opportunities for critical reflection support the transition process and there is a need to theoretically ground such understanding.

What this paper adds

The paper draws on Bakhtin's notion of ideological becoming to explore how learning spaces for educator discussion and reflection can be used to facilitate the transition process.

The findings show how learning spaces can be designed to enable faculty to develop the skills to navigate and challenge dominant discourses of online learning.

The development of critical awareness among educators can also facilitate the development of educational practices for both classroom and online teaching.

Implications for practice and/or policy

The transition to online education is not an individual activity, but a collaborative and dialogical process.

Faculty need time and space to critically challenge dominant discourses of online education and to re‐establish their existing skills and experience within an online context.

This should not be a one‐off event but an ongoing process and conversation in a constantly changing and evolving higher education context.

At the policy level, we should not expect online educational practice to be based on one approach or model, but to celebrate individuality and innovation.
Risk factors for CAR‐T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan
Authors: Jo Tomoyasu , Yoshihara Satoshi , Okuyama Yoshiki , Fujii Keiko , Henzan Tomoko , Kahata Kaoru , Yamazaki Rie , Takeda Wataru , Umezawa Yoshihiro , Fukushima Kentaro , Ashida Takashi , Yamada‐Fujiwara Minami , Hanajiri Ryo , Yonetani Noboru , Tada Yuma , Shimura Yuji , Nishikii Hidekazu , Shiba Norio , Mimura Naoya , Ando Jun , Sato Takayuki , Nakashima Yasuhiro , Ikemoto Junko , Iwaki Keita , Fujiwara Shin‐ichiro , Ri Masaki , Nagamura‐Inoue Tokiko , Tanosaki Ryuji , Arai Yasuyuki 
Published: April 2023

SummaryFor successful chimeric antigen receptor T (CAR‐T) cell therapy, CAR‐T cells must be manufactured without failure caused by suboptimal expansion. In order to determine risk factors for CAR‐T cell manufacturing failure, we performed a nationwide cohort study in Japan and analysed patients with diffuse large B‐cell lymphoma (DLBCL) who underwent tisagenlecleucel production. We compared clinical factors between 30 cases that failed (7.4%) with those that succeeded (n = 378). Among the failures, the proportion of patients previously treated with bendamustine (43.3% vs. 14.8%; p < 0.001) was significantly higher, and their platelet counts (12.0 vs. 17.0 × 104/μL; p = 0.01) and CD4/CD8 T‐cell ratio (0.30 vs. 0.56; p < 0.01) in peripheral blood at apheresis were significantly lower than in the successful group. Multivariate analysis revealed that repeated bendamustine use with short washout periods prior to apheresis (odds ratio [OR], 5.52; p = 0.013 for ≥6 cycles with washout period of 3–24 months; OR, 57.09; p = 0.005 for ≥3 cycles with washout period of <3 months), low platelet counts (OR, 0.495 per 105/μL; p = 0.022) or low CD4/CD8 ratios (<one third) (OR, 3.249; p = 0.011) in peripheral blood at apheresis increased the risk of manufacturing failure. Manufacturing failure remains an obstacle to CAR‐T cell therapy for DLBCL patients. Avoiding risk factors, such as repeated bendamustine administration without sufficient washout, and risk‐adapted strategies may help to optimize CAR‐T cell therapy for DLBCL patients.
Power and bias in industrial relations research
Authors: Doucouliagos Anthony , Doucouliagos Hristos , Stanley T. D. 
Published: April 2023

AbstractWe survey 20,439 estimates from 64 distinct research areas to assess power, bias and statistical significance in industrial relations research. The average estimate published in industrial relations research lacks adequate power; average power is 33 per cent, and median power is only 14 per cent, much lower than the conventional 80 per cent standard. Low power means that industrial relations researchers will find it more difficult to detect important associations pertaining to workplace relations. Low power also leads to exaggerated research findings. We find substantial publication bias in industrial relations research, though nearly half of the research areas have little or no bias.