bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Effects of Statins: Promising Drug for Topical and
Transdermal Administration
Authors: Zahedipour Fatemeh , Hosseini Seyede Atefe , Reiner Željko , Tedeschi-Reiner Eugenia , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: May 2023

Abstract:
Statins are HMG-CoA reductase inhibitors and decrease plasma low-density
lipoprotein cholesterol (LDL-C) levels. They are well tolerated, and because of their
LDL-C-lowering effect, they are utilized to decrease the risk of atherosclerosis and cardiovascular
disease. However, statins have pleiotropic effects, including immunomodulatory,
anti-inflammatory, antioxidant, and anticancer. Currently, oral administration is the
only Food and Drug Administration (FDA)-approved route of administration for statins.
However, other administration routes have demonstrated promising results in different
pre-clinical and clinical studies. For instance, statins also seem beneficial in dermatitis,
psoriasis, vitiligo, hirsutism, uremic pruritus, and graft-versus-host disease. Topically applied
statins have been studied to treat seborrhea, acne, rhinophyma, and rosacea. They also
have beneficial effects in contact dermatitis and wound healing in animal studies,
(HIV) infection, osseointegration, porokeratosis, and some ophthalmologic diseases. Topical
and transdermal application of statins is a non-invasive drug administration method
that has shown significant results in bypassing the first-pass metabolism in the liver,
thereby reducing possible adverse effects. This study reviews the multifaceted molecular
and cellular impacts of statins, their topical and transdermal application, novel delivery
systems, such as nanosystems for topical and transdermal administration and the challenges
concerning this approach.
A Review on Synthesis and Biological Potential of Dihydropyridines
Authors: Pathak Shilpi , Jain Supriya , Pratap Abhishek 
Published: May 2023

Abstract:
Dihydropyridine is an outstanding heterocyclic compound with a wide range of pharmacological potential, including antimicrobial, antioxidant, antitubercular, antiarrhythmic, insecticidal, antihypertensive, vasodilator, anti-inflammatory, antibacterial, antidiabetic and superlative moiety in drug discovery. It is also a versatile pharmacophore, a privileged scaffold, and a distinguished heterocyclic compound. Excellent outcomes have already been shown with novel targets and various modes of action for the dihydropyridines hybrids. This review focused on the mode of action, synthesis, and biological activities. As a result, numerous dihydropyridine candidates are undergoing clinical studies to treat various disorders. This article highlights how novel techniques were used to create dihydropyridines, which may be helpful to researchers in the future.
Palladium (II)-N-heterocyclic Carbene Complexes: Synthesis, Molecular Docking, UV-Vis Absorption and Enzyme Inhibition
Authors: ikhlef Sofiane , Lasmari Sarra , Mokrani El Hassen , Boulcina Raouf , Bensouici Chawki , Gürbüz Nevin , Özdemir Ismail 
Published: May 2023

Background:
Alzheimer's disease is the most prevalent form of dementia; it affects the brain
regions responsible for thought, memory, and language. Dementia cannot currently be cured by any medication.

Objective:
We aimed to synthesize Pd-NHC type PEPPSI and investigate their biological activity in anticholinesterase
enzymes.

Methods:
In this study, we described preparing a series of Pd-NHC type PEPPSI obtained from their
unsymmetrical benzimidazolium salts. These complexes (3a-f) were synthesized from the 2-
chloromethyl-1,3-dioxalane benzimidazolium salts, PdCl2, KBr and pyridine. The compounds (3a-f) were
tested against two enzymes (AChE and BChE).

Results:
The results showed that most of the Palladium–NHC complexes effectively inhibited AChE with
IC50 values in the range of 4.94 - 40.03 μM, and for BChE are in the range of 4.21 - 21.28 μM. The results
showed that the compound (3a) was the most potent inhibitor activity against both AChE and BChE. The
inhibition parameter (IC50) was calculated by the spectrophotometric method. The inhibitory effects of the
synthesized Pd-NHCs were compared to galantamine as a clinical cholinergic enzyme inhibitor. Additionally,
Molecular docking is carried out to estimate the binding pattern between the newly synthesized
compounds and both AChE and BChE active sites.

Conclusion:
The results demonstrated that all synthesized compounds show excellent to moderate inhibition
against the examined enzymes (AChE/BChE).
Identification of the Secondary Metabolites of Sargassum Tenerrimum and their Molecular Docking Analysis against the Targets of Anxiety, Depression and Cognitive Disorder
Authors: Yadav Raman , Kumaravelu Punnagai , Umamaheswari Subburaya , Subramanian Viswanathan , Kantipudi Suvarna Jyoti 
Published: May 2023

Objective:
This article aimed to identify the bioactive compounds present in the brown algae
Sargassum tenerrimum using TLC and HPTLC fingerprinting analysis and followed in silico molecular
docking against a potential target of anxiety, depression, and cognitive disorder with identified compounds.

Methods:
Bioactive compounds were identified from the methanolic extract of Sargassum tenerrimum
through TLC and HPTLC fingerprinting analysis. In silico molecular docking against a potential target of
anxiety, depression, and cognitive disorder was performed on the latest version of AutoDock Vina v.1.2.0
software. The pharmacokinetic profile and possible bioactivities of the compounds were predicted using
SwissADME.

Results:
Fucoxanthin, β-Cryptoxanthin, and Canthaxanthin were identified from the brown algae Sargassum
tenerrimum through TLC and HPTLC fingerprinting analysis. Fucoxanthin showed the highest fitness
score of -9.7 kcal/mol, -9.6 kcal/mol, and -9.7 kcal/mol against the target protein GABA-A, 5ht2c,
and AchE, respectively. β-Cryptoxanthin showed the highest fitness score of -9.4 kcal/mol against target
SERT compared with Fucoxanthin and Canthaxanthin. Canthaxanthin exhibited the highest fitness score-
7.5 kcal/mol, -9.0 kcal/mol, -9.7 kcal/mol, -9.1 kcal/mol, -9.1 kcal/mol, -7.4 kcal/mol, -7.9 kcal/mol and -
7.6 kcal/mol against the target receptor trkB, 5ht1A, D2, DAT, MOA-A, COMT, NMDA and 7nAchR
respectively on the comparing with Fucoxanthin and β-Cryptoxanthin.

Conclusion:
In silico docking and ADME analysis concluded that the canthaxanthin acted through various
targets and was safer than the fucoxanthin and β-Cryptoxanthin. Hence, canthaxanthin can be the best
potential compound in the therapy of neuropsychological disorders.
A Systematic Review of the Application of Machine Learning in CpG
Island (CGI) Detection and Methylation Prediction
Authors: Wei Rui , Zhang Le , Zheng Huiru , Xiao Ming 
Published: May 2023

Background:
CpG island (CGI) detection and methylation prediction play important roles in
studying the complex mechanisms of CGIs involved in genome regulation. In recent years, machine
learning (ML) has been gradually applied to CGI detection and CGI methylation prediction algorithms
in order to improve the accuracy of traditional methods. However, there are a few systematic reviews on
the application of ML in CGI detection and CGI methylation prediction. Therefore, this systematic review
aims to provide an overview of the application of ML in CGI detection and methylation prediction.

Methods:
The review was carried out using the PRISMA guideline. The search strategy was applied to
articles published on PubMed from 2000 to July 10, 2022. Two independent researchers screened the
articles based on the retrieval strategies and identified a total of 54 articles. After that, we developed
quality assessment questions to assess study quality and obtained 46 articles that met the eligibility criteria.
Based on these articles, we first summarized the applications of ML methods in CGI detection and
methylation prediction, and then identified the strengths and limitations of these studies.

Result:
Finally, we have discussed the challenges and future research directions.

Conclusion:
This systematic review will contribute to the selection of algorithms and the future development
of more efficient algorithms for CGI detection and methylation prediction
Development and Characterization of Linezolid loaded Biocompatible Solidlipid
based Nanocarrier for Enhanced Lung Deposition and Anti-tubercular
Activity: Next Generation tailor-made Carrier for Dry Powder Inhaler
Authors: Kamble Ravindra N. , Kausar Eram , Kawadiwale Madhugandha S. , Mali Ashwin J. 
Published: May 2023

Objective:
The objective of the present work was to achieve enhanced site-specific delivery of linezolid (LNZ) to the lung by developing solid lipid nanoparticles (SLN) as a carrier for dry powder inhalers (DPI).

Methods:
The LNZ-loaded SLN (LNZ-SLN) were prepared by hot homogenization method by using Stearic acid, Tween 80, and Pluronic F-68 and further compared with the conventional form of DPI. The developed SLN were evaluated for physical characteristics, in vitro diffusion study, in vitro lung deposition by Andersen Cascade Impactor (ACI), in vitro cell viability study, and acute toxicity of lung tissues.

Results:
The particle size, zeta potential, mass median aerodynamic diameter, and fine particle fraction of the DPI were found to be 1.23±0.07 μm, -10 mV, 1.02±0.04 µm, 44.17±0.73 % respectively which revealed the potential for pulmonary delivery. The encapsulation efficiency was 81±2.08 % and the biphasic release pattern was observed from prepared SLN at pH 7.4.

Conclusion:
The initial burst release of 30% and followed by controlled release (100 %) was observed for 72h. Differential scanning calorimetry and powder X-ray diffraction pointed out the amorphous nature of the LNZ. The Transmission electron microscopy and Scanning electron microscopy reflected the encapsulation of LNZ in SLN. Furthermore, in vitro cell viability study and the histopathological study revealed the biocompatibility and safety of the formulation. The LNZ-SLN DPI ascertained an improved lung deposition with controlled release and the least toxicity as compared to the conventional form of DPI which confirmed its feasibility for pulmonary administration.
Ligand- and Structure-based Approaches for Transmembrane Transporter
Modeling
Authors: Grandits Melanie , Ecker Gerhard F. 
Published: May 2023

Abstract:
The study of transporter proteins is key to understanding the mechanism behind multidrug
resistance and drug-drug interactions causing severe side effects. While ATP-binding transporters
are well-studied, solute carriers illustrate an understudied family with a high number of
orphan proteins. To study these transporters, in silico methods can be used to shed light on the
basic molecular machinery by studying protein-ligand interactions. Nowadays, computational
methods are an integral part of the drug discovery and development process. In this short review,
computational approaches, such as machine learning, are discussed, which try to tackle interactions
between transport proteins and certain compounds to locate target proteins. Furthermore, a
few cases of selected members of the ATP binding transporter and solute carrier family are covered,
which are of high interest in clinical drug interaction studies, especially for regulatory agencies.
The strengths and limitations of ligand-based and structure-based methods are discussed to
highlight their applicability for different studies. Furthermore, the combination of multiple approaches
can improve the information obtained to find crucial amino acids that explain important
interactions of protein-ligand complexes in more detail. This allows the design of drug candidates
with increased activity towards a target protein, which further helps to support future synthetic
efforts.
Improving students’ essay writing skills by implementing peer feedback
Authors: Fatimah Nur , Madya Suwarsih 
Published: May 2023

The aim of this research is improving the students’ writing skill by implementing peer feedback. This study was a three cycle classroom action research at the English Education Department of Ahmad Dahlan University (UAD), Yogyakarta. It focused on the four aspects:designing and teaching the writing class implementing peer feedback, providing writing materials, varying tasks and enhancing students’ participation and interaction with peers in the learning process. The subjects consisted of 22 semester 4 students of Essay Writing-Class E. The quantitative data were collected through students’ essay scores, whereas the qualitative data were through fieldnotes, interview and portfolio. The research results in these findings. First, the students’ participation in the learning process is enhanced through their pair work, group work and whole class activity. By working collaboratively, the students take advantages of giving feedback improving their essay on these aspects:organization, content, grammar, spelling, punctuation, and mechanics, style and quality of expression. Second, the students’ essay writing improves after peer feedback.Their essay mean scores increase from 63.09; 67.23 to 70.09.
Pengaruh motivasi belajar, fasilitas belajar, dan penguasaan kosakata terhadap prestasi belajar bahasa Inggris siswa
Authors: Molyaningrum Noredyo , Suyata Pujiati 
Published: May 2023

Penelitian ini bertujuan untuk mengidentifikasi pengaruh: (1) motivasi belajar, fasilitas belajar, dan penguasaan kosakata secara bersama-sama terhadap prestasi belajar bahasa Inggris siswa kelas VIII Kota Yogyakarta, (2) motivasi belajar terhadap prestasi belajar bahasa Inggris siswa kelas VIII Kota Yogyakarta. (3) fasilitas belajar terhadap prestasi belajar bahasa Inggris siswa kelas VIII Kota Yogyakarta, dan (4) penguasaan kosakata terhadap prestasi belajar bahasa Inggris siswa kelas VIII Kota Yogyakarta. Jenis penelitian ini adalah ex-post facto. Instrumen penelitian adalah angket dan tes. Hasil penelitian adalah: (1) Motivasi belajar, fasilitas belajar, dan penguasaan kosakata secara bersama-sama berpengaruh terhadap prestasi belajar bahasa Inggris siswa, (2) Motivasi belajar berpengaruh terhadap prestasi belajar bahasa Inggris siswa, (3) Fasilitas belajar berpengaruh terhadap prestasi belajar bahasa Inggris siswa, dan (4) Penguasaan kosakata berpengaruh terhadap prestasi belajar bahasa Inggris. Penguasaan kosakata paling berpengaruh terhadap prestasi belajar bahasa Inggris siswa. The effect of learning motivation, learning facilities, and vocabulary mastery on English achievement Abstract: This research aims to investigate the effect of: (1) learning motivation, learning facilities, and vocabulary mastery in aggregate on English achievement of grade VIII students of junior high schools in Yogyakarta, (2) learning motivation on English achievement of grade VIII students of junior high schools in Yogyakarta, (3) learning facilities on English achievement of grade VIII students of junior high schools in Yogyakarta, and (4) vocabulary mastery on English achievement of grade VIII students of junior high schools in Yogyakarta. This research was an ex-post facto. The instruments of the research were questionnaires and tests. The results of the study are: (1) learning motivation, learning facilities, and vocabulary mastery in aggregate affect English achievement of the students , (2) learning motivation affects English achievement of the students, (3) learning facilities affects English achievement of the students, (4) vocabulary mastery affects English achievement of the students. The vocabulry mastery is the most influential on English achievement of the students.
Perwujudan budaya masyarakat Sasak dalam novel-novel karya Salman Faris
Authors: Hadi Syamsul , Wiyatmi Wiyatmi 
Published: May 2023

Penelitian ini bertujuan untuk mendeskripsikan perwujudan budaya masyarakat Sasak dalam novel-novel karya Salman Faris.Penelitian ini merupakan penelitian kualitatif dengan metode konten analisis atau analisis isi yang menemukan, mendeskripsikan, menganalisis, dan mendapatkan data secara empiris dalam novel-novel karya Salman Faris. Objek penelitian ini adalah novel Perempuan Rusuk Dua, Guru Onyeh dan Guru Dane. Teknik pengumpulan data pada penelitian ini dilakukan dengan teknik dokumenter yaitu dengan cara melihat atau mengamati, melakukan pencatatan yang sistematis, dan mencari sumber atau referensi. Hasil penelitian ini sebagai berikut. Wujud budaya masyarakat Sasak dalam novel-novel karya Salman Faris terdiri dari delapan aspek, yaitu: 1) agama dan sistem kepercayaan masyarakat suku Sasak, 2) bahasa masyarakat suku Sasak, 3) sistem pengetahuan masyarakat suku Sasak, 4) sistem peralatan dan teknologi masyarakat suku Sasak, 5) sistem organisasi masyarakat suku Sasak, 6) sistem mata pencaharian hidup masyarakat suku Sasak, 7) tradisi/adat-istiadat masyarakat suku Sasak, dan 8) kesenian masyarakat suku Sasak. Realization cultural of Sasak people in Salman Faris’ novels Abstract: This study aims to describe the cultural of Sasak people in Salman Faris’ novels. This research is a qualitative study using content analysis that locates, describes, analyzes, and obtains empirical data in the novels by Salman Faris. The objects of this study were novel Perempuan Rusuk Dua, Guru Onyeh, and Guru Dane. Data in this study were collected using documentation by seeing or observing, doing the systematic recording, and looking for a source or reference. The results of this study are as follows. The form of Sasak cultures in the to novels by Salman Faris consists of eight: (1) religion and belief system of Sasak society, (2) the language of Sasak society, (3) Sasak community knowledge systems, (4) systems of equipment and technology of Sasak community, (5) Sasak community organization systems, (6) livelihood systems of Sasak’s life, (7) traditions/customs of Sasak society, and (8) Sasak community arts.
Representasi konten budaya pada buku ajar bahasa Prancis Super Francais kelas X SMA/MA
Authors: Indrawan Adam , Yulianto Bambang , Sodiq Syamsul 
Published: May 2023

Penelitian ini bertujuan mengidentifikasi perbandingan luasan representasi dari kemunculan domain dan aspek budaya serta menemukan kategori domain dan aspek budaya yang paling dominan muncul pada buku ajar Super Francais kelas X SMA/MA yang diterbitkan oleh penerbit lokal Erlangga. Analisis buku tersebut menggunakan metode konten analisis dalam bentuk deskriptif kualitatif. Elemen kuantitatif pada penelitian ini digunakan untuk mengidentifikasi jumlah dan persentase kemunculan konten budaya. Hasil penelitian menunjukkan terdapat ketidakseimbangan representasi konten budaya yang disajikan pada sisi domain dan aspek budaya. Konten yang disajikan secara keseluruhan mencakup domain budaya yang diajukan (Indonesia, Prancis, negara frangkofon dan Internasional). Luasan kemunculan pada keseluruhan empat aspek budaya yang diajukan oleh Yuen hanyak mencakup domain budaya Indonesia dan Prancis, sedangkan domain budaya internasional dan frangkofon terbatas pada aspek produk dan penokohan. Represenrasi domain budaya Prancis menjadi paling dominan yang terdiri atas 48,64% dari total konten budaya yang ditemukan. Sedangkan representasi aspek budaya yang ditonjolkan adalah aspek produk dengan total temuan sebesar 78,37% dimana 37.5% merupakan aspek produk budaya Prancis yang paling sering muncul dibanding domain budaya Indonesia dan domain lainnya. Secara keseluruhan, luasan dan kategori domain dan aspek budaya yang disajikan merepresentasikan lapisan dasar / pengetahuan umum mengenai negara Prancis. The representation of cultural contents in the textbook Super Francais for senior high school grade X AbstractThis study aims to identify the appearing comparison of the wide representation and to find out the most appearing categories in cultural aspects and cultural domains from Super Francais Textbook for Senior High School grade X published by local publisher Erlangga. Content analysis is used as the methodology in form of qualitative descriptive. Quantitative element is used to investigate the number and percentage appearances of the cultural contents. The results indicate that there is an imbalance in the representation of cultural content presented in the domain and cultural aspects. The contents generally have covered the whole cultural domain (Indonesia, France, francophone countries and International). The wide appearance in all four cultural aspects proposed by Yuen only covers the cultural domains of Indonesia and France, while for international and francophone countries are limited, only on the aspects of product and person. The most representation is dominated by French culture which made up 48.64% of the total cultural appearances. While the highlighted cultural aspects is an aspect of product with a total finding 78.37% in which 37.5% is the French domain as the most appearing compared to the Indonesian and others. Overall, the extent and category of domains and cultural aspects presented represent the basic layer/general knowledge of French.
Using Continuous Passive Assessment Technology to Describe Health and Behavior Patterns Preceding and Following a Cancer Diagnosis in Older Adults: Proof-of-Concept Case Series Study
Authors: Wu Chao-Yi , Tibbitts Deanne , Beattie Zachary , Dodge Hiroko , Shannon Jackilen , Kaye Jeffrey , Winters-Stone Kerri 
Published: May 2023

Background
Describing changes in health and behavior that precede and follow a sentinel health event, such as a cancer diagnosis, is challenging because of the lack of longitudinal, objective measurements that are collected frequently enough to capture varying trajectories of change leading up to and following the event. A continuous passive assessment system that continuously monitors older adults’ physical activity, weight, medication-taking behavior, pain, health events, and mood could enable the identification of more specific health and behavior patterns leading up to a cancer diagnosis and whether and how patterns change thereafter.

Objective
In this study, we conducted a proof-of-concept retrospective analysis, in which we identified new cancer diagnoses in older adults and compared trajectories of change in health and behaviors before and after cancer diagnosis.

Methods
Participants were 10 older adults (mean age 71.8, SD 4.9 years; 3/10, 30% female) with various self-reported cancer types from a larger prospective cohort study of older adults. A technology-agnostic assessment platform using multiple devices provided continuous data on daily physical activity via wearable sensors (actigraphy); weight via a Wi-Fi–enabled digital scale; daily medication-taking behavior using electronic Bluetooth-enabled pillboxes; and weekly pain, health events, and mood with online, self-report surveys.

Results
Longitudinal linear mixed-effects models revealed significant differences in the pre- and postcancer trajectories of step counts (P<.001), step count variability (P=.004), weight (P<.001), pain severity (P<.001), hospitalization or emergency room visits (P=.03), days away from home overnight (P=.01), and the number of pillbox door openings (P<.001). Over the year preceding a cancer diagnosis, there were gradual reductions in step counts and weight and gradual increases in pain severity, step count variability, hospitalization or emergency room visits, and days away from home overnight compared with 1 year after the cancer diagnosis. Across the year after the cancer diagnosis, there was a gradual increase in the number of pillbox door openings compared with 1 year before the cancer diagnosis. There was no significant trajectory change from the pre– to post–cancer diagnosis period in terms of low mood (P=.60) and loneliness (P=.22).

Conclusions
A home-based, technology-agnostic, and multidomain assessment platform could provide a unique approach to monitoring different types of behavior and health markers in parallel before and after a life-changing health event. Continuous passive monitoring that is ecologically valid, less prone to bias, and limits participant burden could greatly enhance research that aims to improve early detection efforts, clinical care, and outcomes for people with cancer.