bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ilizarov technique in the management of haemophilic knee flexion contracture
Authors: Wei Zhanqi , Cao Qing , Zhu Wei , Feng Bin , Weng Xisheng 
Published: February 2023

AbstractIntroductionThe Ilizarov technique has the potential to be an attractive option for severe knee flexion contracture (KFC) patients with a high risk of bleeding. However, studies on this technique in the management of haemophilic KFC are scarce.AimThe purpose of this study was to review and analyse the results of the Ilizarov technique in correcting haemophilic KFC and to evaluate the safety and efficacy of this technique.MethodsTwelve male haemophilia patients with severe KFC who underwent distraction treatment using the Ilizarov technique from June 2013 to April 2019 were included in this study. The hospital day, flexion contracture, range of motion (ROM) of the knees, complications and functional outcomes were recorded and analysed. Functional outcomes were evaluated according to the Hospital for Special Surgery (HSS) knee scores of the preoperation, end of distraction and last follow‐up.ResultsThe average preoperative flexion contracture and range of motion (ROM) of the knees were 55 ± 15° and 66 ± 18°, respectively. The average preoperative HSS knee score was 47 ± 5. The average duration of follow‐up was 75.5 ± 30.1 months. All flexion contractures achieved full correction (≤5°) at the end of distraction, and the flexion contracture significantly decreased to 6 ± 5° at the last follow‐up (p < .0001). The ROM of the knees was significantly increased at the last follow‐up compared with that before distraction treatment (p < .0001). The HSS knee scores at the end of distraction and at the last follow‐up were both significantly higher than the preoperative HSS knee score (p < .0001). No major complications were encountered.ConclusionsThis study provided evidence for the safety and effectiveness of Ilizarov technique plus physical therapy in the management of haemophilic KFC and accumulated clinical experience for the proper application of this technology.
Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease
Authors: Oeda Satoshi , Seko Yuya , Hayashi Hideki , Arai Taeang , Iwaki Michihiro , Yoneda Masato , Shima Toshihide , Notsumata Kazuo , Ikegami Tadashi , Fujii Hideki , Toyoda Hidenori , Miura Kouichi , Morishita Asahiro , Kawata Kazuhito , Tomita Kengo , Kawanaka Miwa , Isoda Hiroshi , Yamaguchi Kanji , Fukushima Hideaki , Kamada Yoshihiro , Sumida Yoshio , Aishima Shinichi , Itoh Yoshito , Okanoue Takeshi , Nakajima Atsushi , Takahashi Hirokazu ,   Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)
Published: February 2023

AbstractAimAgile 3+ and Agile 4 scores, based on liver stiffness measurement (LSM) by transient elastography and clinical parameters, were recently reported to be effective in identifying advanced fibrosis and cirrhosis in nonalcoholic fatty liver disease (NAFLD). This study aimed to validate the utility of these scores in Japanese patients with NAFLD.MethodsSix hundred forty‐one patients with biopsy‐proven NAFLD were analyzed. The severity of liver fibrosis was pathologically evaluated by one expert pathologist. The LSM, age, sex, diabetes status, platelet count, and aspartate aminotransferase and alanine aminotransferase levels were used to calculate Agile 3+ scores, and the parameters above excluding age were used for Agile 4 scores. The diagnostic performance of the two scores was evaluated using receiver operating characteristic (ROC) curve analysis. Sensitivity, specificity, and predictive values of the original low cut‐off (for rule‐out) value and high cut‐off (for rule‐in) value were tested.ResultsFor diagnosis of fibrosis stage ≥3, the area under the ROC (AUROC) was 0.886, and the sensitivity of the low cut‐off value and the specificity of the high cut‐off value were 95.3% and 73.4%, respectively. For diagnosis of fibrosis stage 4, AUROC, the sensitivity of the low cut‐off value, and the specificity of the high cut‐off value were 0.930, 100%, and 86.5%, respectively. Both scores had higher diagnostic performance than the FIB‐4 index and the enhanced liver fibrosis score.ConclusionsAgile 3+ and Agile 4 are reliable noninvasive tests to identify advanced fibrosis and cirrhosis in Japanese NAFLD patients with adequate diagnostic performance.
Women's experiences of age‐related discontinuation from mammography screening: A qualitative interview study
Authors: Gram Emma G. , Knudsen Sigrid W. , Brodersen John Brandt , Jønsson Alexandra Brandt R. 
Published: February 2023

AbstractIntroductionIn Denmark, women are discontinued from mammography screening at age 69 due to decreased likelihood of benefits and increased likelihood of harm. The risk of harm increases with age and includes false positives, overdiagnosis and overtreatment. In a questionnaire survey, 24 women expressed unsolicited concerns about being discontinued from mammography screening due to age. This calls for further investigation of experiences related to discontinuation from screening.MethodsWe invited the women, who had left comments on the questionnaire, to participate in in‐depth interviews with the purpose to explore their reactions, preferences, and conceptions about mammography screening and discontinuation. The interviews lasted 1–4 h and were followed up with a telephone interview 2 weeks after the initial interview.ResultsThe women had high expectations of the benefits of mammography screening and felt that participation was a moral obligation. Following that, they perceived the screening discontinuation as a result of societal age discrimination and consequently felt devalued. Further, the women perceived the discontinuation as a health threat, felt more susceptible to late diagnosis and death, and therefore sought out new ways to control their risk of breast cancer.ConclusionOur findings indicate that the age‐related discontinuation from mammography screening might be of more importance than previously assumed. This study raises important questions about screening ethics, and we encourage research to explore this in other settings.Patient and Public ContributionThis study was conducted as a result of the women's unsolicited concerns about being discontinued from screening. This particular group contributed to the study with their own statements, interpretations and perspectives on the discontinuation of screening, and the initial analysis of data was discussed with the women during follow‐up interviews.
Effect of Ni foam on the microstructure and properties of AlN ceramic/Cu brazed joint
Authors: Guo Weibing , Yu Zhanlong , Ding Zhijie , Bian Wenshan , Xue Haitao , Li Anhang , Hu Yiren , Fan Chong 
Published: February 2023

AbstractAluminum nitride (AlN) ceramics and oxygen‐free Cu were brazed with multilayer filler consisted of Ag‐Cu‐Ti +Ni foam. The microstructure and forming principle of AlN/Cu joints were studied and the influence of Ni foam on the joints was focused. The result shows that the composition of AlN/Cu joint was AlN/TiN/Ni3Ti+Cu(s,s)+CuTi+Ni foam+Ag(s,s)/Cu. The joint strength was only 66.7 ± 3.7MPa with pure Ag‐Cu‐Ti solder and the fracture occurred inside AlN ceramics due to the residual stress. The foam nickel reacted with Ag‐Cu‐Ti filler metal to form Ni3Ti during brazing process. Ni foam still retained the basic skeleton structure during brazing, and the mechanical capacity of AlN/Cu joint was enhanced significantly. The maximum shear strength of the brazed joint can reach 89.6 ± 4.5 MPa with .1 mm Ni foam, and the fracture position changed to the brazing filler. The result shows that nickel foam can reduce the residual thermal stress, and the mechanical properties of AlN/Cu joints were improved.
Killer cell immunoglobulin‐like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus‐1 infection in the Japanese population
Authors: Naruse Taeko K. , Konishi‐Takemura Makiko , Yanagida Risa , Sharma Gaurav , Vajpayee Madhu , Terunuma Hiroshi , Mehra Narinder K. , Kaur Gurvinder , Kimura Akinori 
Published: February 2023

AbstractOne of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV‐1 infection in the Japanese and Indian populations, implying that KIR3DL1*007‐positive NK cells might eliminate HIV‐infected cells less effectively than NK cells bearing the other KIR3DL1 alleles or KIR3DS1 alleles.
A new second‐order conic optimization model for the Euclidean Steiner tree problem in Rd$\mathbb {R}^d$
Authors: Pinto Renan Vicente , Ouzia Hacène , Maculan Nelson 
Published: February 2023

AbstractIn this work, a new second‐order conic optimization model for the Euclidean Steiner tree problem in d‐space, where the dimension d is at least three, will be presented. Also, two strategies for eliminating isomorphic trees will be developed. Computational results highlighting the efficiency of this model compared to existing models for the Euclidean Steiner tree problem will be discussed. Finally, enforcing the proposed model with any of the isomorphic tree elimination strategies permits us to compute for the first time, to the best of our knowledge, the minimum Steiner tree for the cube in .
Far from equilibrium ultrafast high‐temperature sintering of ZrO2–SiO2 nanocrystalline glass–ceramics
Authors: Fu Le , Wu Jinghua , Sathyanath Sharath Kumar Manjeshwar , Wang Bohan , Leifer Klaus , Engqvist Håkan , Grasso Salvatore , Xia Wei 
Published: February 2023

AbstractUltrafast high‐temperature sintering (UHS) is a novel sintering technique with ultrashort firing cycles (e.g., a few tens of seconds). The feasibility of UHS has been validated on several ceramics and metals; however, its potential in consolidating glass–ceramics has not yet been demonstrated. In this work, an optimized carbon‐free UHS was utilized to prepare ZrO2–SiO2 nanocrystalline glass–ceramics (NCGCs). The phase composition, grain size, densification behavior, and microstructures of NCGCs prepared by UHS were investigated and compared with those of samples sintered by pressureless sintering. Results showed that NCGCs with a high relative density (～95%) can be obtained within ～50 s discharge time by UHS. The UHS processing not only hindered the formation of ZrSiO4 and cristobalite but also enhanced the stabilization of t‐ZrO2. Meanwhile, owing to the ultrashort firing cycles, the UHS technology allowed the NCGCs to be consolidated in a far from equilibrium state. The NCGCs showed a microstructure of spherical monocrystalline ZrO2 nanocrystallites embedded in an amorphous SiO2 matrix.
“You want to be politically correct”: Opposition to political correctness predicts less adherence to COVID‐19 guidelines in the US
Authors: Mackey Cameron D. , Rios Kimberly , Johnson Evan 
Published: February 2023

AbstractPrevious research has demonstrated that conservative individuals (relative to liberal individuals) were less likely to adhere to COVID‐19 guidelines (e.g., social distancing). We argue that because adherence to COVID‐19 guidelines was largely characterized as “politically correct” behavior, individuals opposed to political correctness (PC) norms would follow COVID‐19 guidelines less, controlling for political conservatism and other relevant demographic variables. In two correlational studies and one preregistered experiment, we tested whether opposition to political correctness (OPC) predicts less adherence to COVID‐19 guidelines. Study 1 showed that OPC correlates negatively with mask‐wearing and social distancing, controlling for conservatism, gender, age, and religious identity. Study 2 replicated and extended these effects, demonstrating that seeing mask‐wearing as a common good (i.e., as a beneficial COVID‐19 mitigation strategy) mediated the relationship between OPC and mask‐wearing, social distancing, handwashing, and vaccination intentions. Study 3 experimentally manipulated feelings toward PC. Inconsistent with our preregistered hypothesis but consistent with previous research, participants induced to have positive feelings toward PC adhered to COVID‐19 guidelines the most and had the most positive feelings toward wearing masks. We discuss how moralization of health guidelines can predict individuals' likelihood of adhering to these guidelines. We also discuss how best to persuade individuals who see adherence to health guidelines as “politically correct,” as well as future research directions to address this concern.
Anti‐BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis
Authors: Cordel Nadège , Flament Jasmine , Jouen Fabienne , Seta Vannina , Tancrède‐Bohin Emmanuelle , Dahan Catherine Picard , Konstantinou Maria‐Polina , Dereure Olivier , Quéreux Gaëlle , Prost Catherine , Bedane Christophe , Debarbieux Sébastien , Lacour Jean‐Philippe , Dompmartin Anne , Wierzbicka‐Hainaut Ewa , Villada Isabelle Bourgault , Oro Saskia Ingen Housz , Vabres Pierre , Richard Marie‐Aleth , Delaporte Emmanuel , Pham‐Ledard Anne , Leccia Marie‐Thérèse , Litrowski Noémie , Michel Catherine , Lagrange Brigitte , D'Incan Michel , Abasq Claire , Duvert‐Lehembre Sophie , Dupuy Alain , Alcaraz Isabelle , Breton‐Guitarian Anne‐Laure , Lombart Florian , Estève Eric , Machet Laurent , Del Giudice Pascal , Fenot Marion , Belmondo Thibaut , Morin Florence , Guérin Olivia , Benichou Jacques , Tressières Benoît , Joly Pascal ,   for the French study Group on autoimmune bullous skin diseases
Published: February 2023

AbstractBackgroundAdverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet.ObjectivesTo assess a potential relationship between the occurrence of APO and the serum value of anti‐BP180 antibodies at the time of PG diagnosis.MethodsMulticentre retrospective study conducted from January 2009 to December 2019 in 35 secondary and tertiary care centres. Inclusion criteria: (i) diagnosis of PG according to clinical, histological and immunological criteria, (ii) ELISA measurement of anti‐BP180 IgG antibodies determined at the time of PG diagnosis with the same commercial kit and (iii) obstetrical data available.ResultsOf the 95 patients with PG included, 42 had one or more APO, which mainly corresponded to preterm birth (n = 26), intrauterine growth restriction (IUGR) (n = 18) and small weight for gestational age at birth (n = 16). From a ROC curve, we identified a threshold of 150 IU ELISA value as the most discriminating to differentiate between patients with or without IUGR, with 78% sensitivity, 55% specificity, 30% positive and 91% negative predictive value. The threshold >150 IU was confirmed using a cross‐validation based on bootstrap resampling, which showed that the median threshold was 159 IU. Upon adjusting for oral corticosteroid intake and main clinical predictors of APO, an ELISA value of >150 IU was associated with the occurrence of IUGR (OR = 5.11; 95% CI: 1.48–22.30; p = 0.016) but not with any other APO. The combination of blisters and ELISA values higher than 150 IU led to a 2.4‐fold higher risk of all‐cause APO (OR: 10.90; 95% CI: 2.33–82.3) relative to patients with blisters but lower values of anti‐BP180 antibodies (OR of 4.54; 95% CI 0.92–34.2).ConclusionThese findings suggest that anti‐BP180 antibody ELISA value in combination with clinical markers is helpful in managing the risk of APO, in particular IUGR, in patients with PG.
Development of Measurement Tools to Assess Cumulative Life Course Impairment in Patients with Chronic Skin Diseases
Authors: Braren‐von Stülpnagel Catharina C. , Augustin Matthias , Westphal Lukas , Sommer Rachel 
Published: February 2023

AbstractIntroductionPatients with chronic skin diseases suffer from physical, psychological, emotional and social impairments. The overall burden has significant impact on patients' life, contributing to irreversible damage across many domains, known as cumulative life course impairment (CLCI). The aim of this project was to develop instruments which (a) measure persisting CLCI and (b) identify patients at risk for developing future CLCI.MethodsWe identified key topics that negatively impact life course due to skin disease patient‐reported open item selection. Subsequently, we conducted focus group interviews with patients and experts to conceptualize items and response scales, resulting in two preliminary measurement tools. These tools were tested in a cognitive debriefing before finalization.ResultsConsecutively, 162 patients participated in the open item selection and indicated the following topics were most relevant to their disease: disease symptoms, risk behaviour, comorbidities, psychological and emotional impairments, physical impairments, occupational impairments, treatment, sexuality, problems with family or friends, everyday life and positive event or decisions because of the disease. In the focus group interviews, patients reported stigmatization, support at disease onset, pre‐existing diseases and age of onset as additional important topics. The cognitive debriefing resulted in minor changes to sentence structure. The final tools included: (1) DermCLCI‐r, which assesses retrospective CLCI, and (2) DermCLCI‐p, which assesses current CLCI and future risk. Each tool consisted of 30 items.DiscussionThe newly developed measures allow for early identification of CLCI, facilitate adequate dermatological and psychosocial interventions and may contribute to the prevention of CLCI. Further validation studies will be performed.
Excess psoriasis and psoriatic arthritis mortality during the COVID‐19 pandemic in the United States: A nationwide population‐based study from 2010 to 2021
Authors: Liu Ying , He Xinyuan , Lee Ernest Y. , Lv Fan , Yao Leiqing , Meng Qinqin , Zhang Lan , Ng Wee Han , Zhang Yanfei , Elias Peter M. , Man Maoqiang , Yeo Yee Hui , Li Zhengxiao 
Published: February 2023

AbstractBackgroundLittle is known about mortality trends among patients with psoriasis (PsO) and psoriatic arthritis (PsA) in the United States.ObjectivesTo ascertain mortality trends of PsO and PsA between 2010 and 2021, focusing on the effects of the COVID‐19 pandemic.MethodsWe collected data from the National Vital Statistic System and calculated age‐standardized mortality rates (ASMR) and cause‐specific mortality for PsO/PsA. We evaluated observed versus predicted mortality for 2020–2021 based on trends from 2010 to 2019 with joinpoint and prediction modelling analysis.ResultsAmong 5810 and 2150 PsO‐ and PsA‐related deaths between 2010 and 2021, ASMR for PsO dramatically increased between 2010–2019 and 2020–2021 (annual percentage change [APC] 2.07% vs. 15.26%; p < 0.01), leading to a higher observed ASMR (per 100,000 persons) than predicted for 2020 (0.27 vs. 0.22) and 2021 (0.31 vs. 0.23). The excess mortality of PsO was 22.7% and 34.8% higher than that in the general population in 2020 (16.4%, 95% CI: 14.9%–17.9%) and 2021 (19.8%, 95% CI: 18.0%–21.6%) respectively. Notably, the ASMR rise for PsO was most pronounced in the female (APC: 26.86% vs. 12.19% in males) and the middle‐aged group (APC: 17.67% vs. 12.47% in the old‐age group). ASMR, APC and excess mortality for PsA were similar to PsO. SARS‐CoV‐2 infection contributed to more than 60% of the excess mortality for PsO and PsA.ConclusionsIndividuals living with PsO and PsA were disproportionately affected during the COVID‐19 pandemic. Both ASMRs increased at an alarming rate, with the most pronounced disparities among the female and middle‐aged groups.
Increasing the COVID‐19 immunization rate through allergy testing
Authors: Bent R. K. , Weinbrenner J. , Faihs V. , Steffens S. , Nau T. , Vitus M. , Mathes S. , Darsow U. , Biedermann T. , Brockow K. 
Published: February 2023

AbstractBackgroundVaccination of the population is required to combat the COVID‐19 pandemic. Allergy testing could reduce anxiety towards COVID‐19 vaccination and thereby may increase vaccination rate, however, its effectiveness remains unclear.MethodsOne hundred and thirty prospective real‐life patients in need of but not daring to get vaccinated asked for allergy workup for COVID‐19 vaccine hypersensitivity in 2021/2022. Characterization of patients, identification of anxieties, decrease of patient's anxiety levels, overall vaccination rate and adverse reactions after vaccination were assessed.ResultsTested patients were characterized by being female (91.5%) and having a high rate of previous allergies (e.g. to food 55.4%, drugs 54.6%, or previous vaccinations 50%) and dermatological disease (29.2%) but not always had medical contraindications for COVID‐19 vaccination. Sixty one patients (49.6%) were highly concerned (4‐6, Likert scale 0‐6) about vaccination and 47 (37.6%) expressed resolving thoughts about vaccinaion anaphylaxis (3‐6, Likert scale 0‐6). However only 35 patients (28.5%) were scared of getting COVID‐19 within 2 months (4–6, Likert scale 0–6) and only 11 (9%) patients had high expectations of getting COVID‐19 (4–6, Likert scale 0–6). Allergy testing significantly (p < 0.01 to p < 0.05 respectively) reduced the median anxiety of allergic symptoms following vaccination: dyspnoea (4.2–3.1), to faint (3.7–2.7), long‐term consequences (3.6–2.2), pruritus (3.4–2.6), skin rash (3.3–2.6) and death (3.2–2.6). After allergy testing, most patients (108/122, 88.5%) let themselves be vaccinated within 60 days. Revaccinated patients with previous symptoms experienced a reduction of symptoms (p < 0.05) upon revaccination.ConclusionsPatients not daring to get vaccinated have more anxiety towards vaccination than to acquire COVID‐19. For those, allergy testing excludes vaccine allergy, and is a tool to increase vaccination willingness and thereby helps to combat vaccination hesitancy.
Colorimetric indicator films developed by incorporating anthocyanins into chitosan‐based matrices
Authors: Pang Guiyin , Zhou Chuang , Zhu Xudong , Chen Lianmei , Guo Xiaoqiang , Kang Tairan 
Published: February 2023

AbstractA novel pH‐sensitivity and antimicrobial films based on chitosan (CS), hydroxypropyl methylcellulose (HPMC), ε‐polylysine (ε‐PL) matrix by incorporating purple sweet potato anthocyanins (PSPA) through solvent casting method, has been developed. The Fourier transform infrared spectroscopic (FT‐IR) of the films showed that PSPA was added to CS/HPMC/ε‐PL matrix. The scanning electron microscopic (SEM) and X‐ray diffraction (XRD) spectra indicated that PSPA was well blend in CS/HPMC/ε‐PL‐matrix. The light transmittance rate and moisture contents (MC) of the films decreased by adding PSPA and ε‐PL. Adding an appropriate ε‐PL, the antimicrobial properties films can be improved. When the fish became spoiled, the color of the film was changed from red to green, and the total volatile basic nitrogen (TVB‐N) content was higher than that of Chinese Standard GB 2733–2015 at 36 hr. Therefore, the novel films could be applied in monitoring and packaging the freshness of fish.