bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Aircraft Intelligent Cockpit Auxiliary System based on Big Data and a Single-Chip Microcomputer
Authors: Xu hengqian , Sun Youchao 
Published: August 2023

Abstract
In general, the cockpit is a part of the aircraft which provides proper visibility to both pilots and co-pilots who manage the aircraft. Nowadays, the production of modern aircraft is increasing day by day for effective and safe operation. On the other hand, the automation system and improper design of the cockpit in aircraft cause various incidents when mishandled or due to uncertain weather conditions and it needs to be rectified. Therefore, this paper proposes an aircraft intelligent cockpit auxiliary system based on a single-chip microcontroller. The single-chip computer control system used in this paper is a double STC89C52RC single-chip microcomputer. The STC89C52RC controller is integrated with the cockpit auxiliary system which makes the aircraft fly fast with the propaganda and automatic tracing function thereby ignoring the obstacles. The proposed aircraft cockpit design integrated with STC 89C52RC microcontroller comprises a temperature sensor, pressure sensor, and speed sensor to determine the climatic conditions. In addition to this, a global system for mobile communications (GSM) and a global positioning system (GPS) are also provided to identify the location of an aircraft cockpit and monitor wireless radiation using a short message service (SMS). Finally, the experimental analysis is determining the various parameters to evaluate the efficiency of the proposed aircraft cockpit design.
Prediction of Strong Ground Motion at Somnath Temple
Authors: Angadi Shivamanth , Hiravennavar Apurva , Solanki Chandresh H. , Dodagoudar Goudappa R. 
Published: August 2023

Abstract
Seismic hazard assessment is the key tool for rational planning and designing in seismically vulnerable regions. Gujarat state of India is the only state in peninsular India with maximum seismic hazard of big shallow earthquake originating from Intraplate seismicity. Entire Gujarat region has earthquake hazard of different levels from moderate to high as seismic zones III to V are assigned as per the seismic zoning map of India [IS:1893 Part 1 (2002)]. In the present study, seismic hazard assessment for Gujarat state of India is performed by using state of art probabilistic seismic hazard assessment procedures for selected areas. Using on seismotectonic information a possible fault map is prepared and using calculated regional seismicity parameter, earthquake recurrence relationships are established for each fault. Probabilistic seismic hazard assessment in terms of horizontal component of peak ground acceleration for 5% structural damping for the rock sites are carried out using seven different ground motion prediction equations (GMPEs) including one from India. The output of the seismic hazard computations are then used to develop uniform hazard spectra (UHS) for the two earthquake return periods (i.e.475-years and 2475-years).
Comparison of perioperative outcomes and complications between intracorporeal, extracorporeal, and hybrid ileal conduit urinary diversion during robot-assisted radical cystectomy: A comparative propensity score-matched analysis from nationwide multi-institutional study in Japan
Authors: Morizane Shuichi , Nakane Keita , Tanaka Toshiaki , Zennami Kenji , Muraoka Kentaro , Ebara Shin , Miura Noriyoshi , Uemura Koichi , Sobu Ryuta , Hoshi Akio , Taoka Rikiya , Sugimoto Mikio , Noma Hisashi , Sunada Hiroshi , Nishiyama Hiroyuki , Habuchi Tomonori , Ikeda Ichiro , Saika Takashi , Makiyama Kazuhide , Shiroki Ryoichi , Masumori Naoya , Koie Takuya , Takenaka Atsushi 
Published: August 2023

Abstract
Background
To investigate the impact of different urinary diversion (UD) techniques on the peri- and postoperative complications of robot-assisted radical cystectomy (RARC) with ileal conduit.
Methods
We retrospectively analyzed 373 patients undergoing RARC with ileal conduit at 11 institutions in Japan between April 2018 and December 2021. Propensity score weighting was performed to adjust for confounding factors such as age, sex, body mass index, performance status, American Society of Anesthesiologists score, previous abdominal surgery, neoadjuvant chemotherapy, and preoperative high T stage (≥ cT3) and high N stage (≥ cN1). Perioperative complications were then compared among three groups: extracorporeal, intracorporeal, and hybrid urinary diversion (ECUD, ICUD, and HUD, respectively).
Results
A total of 150, 68, and 155 patients received ECUD, HUD, and ICUD, respectively. Bowel reconstruction time and UD time were significantly shorter in the ECUD group (p < 0.001), and urethrectomy and extended lymph node dissection were significantly performed in the HUD group (p < 0.001). For postoperative complications (Clavien–Dindo Classification grade ≥ 3) within 90 days, surgical site infection (p = 0.004), pelvic abscess (p = 0.013), and anastomotic urine leak (p = 0.007) significantly occurred in the ECUD group. For late complications (grade ≥ 3, after 90 days), pelvic organ prolapse was significantly more common in the ECUD group (p = 0.011).
Conclusions
Although postoperative complications such as infection, uretero-conduit anastomosis–related events, and pelvic organ prolapse were more common in the ECUD group, HUD and ICUD can be safely performed during RARC.
Suicidal ideation and suicide attempt following ketamine prescription in patients with treatment-resistant depression: a nation-wide cohort study
Authors: Xu Rong , Pan Yiheng , Gorenflo Maria , Davis Pamela , Kaelber David , De Luca Susan 
Published: August 2023

Abstract
Ketamine, including esketamine, is an effective treatment for patients with treatment-resistant depression (TRD); however, its long-term efficacy in real-world populations remains poorly characterized. This is a retrospective cohort study using TriNetX US Collaborative Network, a platform aggregating electronic health records (EHRs) data from 93 million patients from 56 health care organizations in the US, and the study population includes 321,367 patients with a diagnosis of TRD who were prescribed relevant treatment in their EHRs. The prescription of ketamine (including esketamine) was associated with significant decreased risk of suicidal ideation compared to prescription of other common antidepressants: HR = 0.65 (95% CI: 0.53 – 0.81) at 1 day – 7 days, 0.78 (95% CI: 0.66 – 0.92) at 1 day – 30 days, 0.81 (95% CI: 0.70 – 0.92) at 1 day – 90 days, 0.82 (95% CI: 0.72 – 0.92) at 1 day – 180 days, and 0.83 (95% CI: 0.74 – 0.93) at 1 day – 270 days. This trend was especially robust among adults over 24 years of age, males, and White patients with TRD. No significant difference was observed for suicide attempts, except significantly increased risk for adolescents (aged 10-24) at 1 day – 30 days with HR = 2.22 (95% CI: 1.01-4.87). This study provides real-world evidence that ketamine has long-term benefits in mitigating suicidal ideation in patients with treatment-resistant depression. Future work should focus on optimizing dosage regimens for ketamine, understanding the mechanism, and the difference in various demographic subpopulations.
Study of oxidation of cellulose by Fenton-type reactions using alkali metal salts as swelling agents
Authors: Tsague Fabien Lucioni , Chimeni Desire Yomeni , Assonfack Herman Lekane , Abo Marina Tatiana , Cheumani Arnaud Maxime Yona , Ndinteh Derek Tantoh , Ndikontar Maurice Kor 
Published: August 2023

Abstract
Cellulose from corn straw was oxidized by Fenton-type reagents (FeSO4. 7H2O or CuCl2. 2H2O) using alkaline metal salts (LiCl; NaCl). Cellulose pre-treatment using alkali metal salts (LiCl; NaCl) coupled with a high H2O2 loading (up to 500 kg per ton of pulp) are used as a novel approach to improve the oxidation rate of oxidized celluloses. The oxidation rate was determined by measuring the aldehyde and carboxylic acid contents of the oxidized cellulose. The oxidized celluloses were characterized by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR), X-ray diffraction (XRD) and thermogravimetric analyses (TGA). The results show that the oxidation efficiency was improved by using the metal salts and increasing the H2O2 loading for both catalytic systems (Fe2+ or Cu2+). The oxidization rate increased gradually with H2O2 loading up to a maximum 500 kg/t of pulp tested without a considerable loss of cellulose structure. The FTIR results revealed that oxidized celluloses exhibit almost similar predominant hydroxyl-based structure as native cellulose with the presence of bands in the regions of 1640-1742 cm-1 characteristic of aldehyde and carboxylic acid groups. The XRD results showed that the crystallinity index slightly decreased from 69.4 to 67-68 and 62-64% after oxidation of the cellulose. The equilibrium moisture contents of oxidized celluloses increased compared to the raw cellulose pulp. The moisture curves fit the page model and exhibits a sub-diffusion process.
Frequency-specific alterations of fractional amplitude of low-frequency fluctuations in adult-onset hypothyroidism
Authors: Shi Qian , Han Yalan , Tian Jing , Huang Gang , Tian Limin , Qin Rui , Cao Jiancang , Zhao Lianping 
Published: August 2023

Abstract

Purpose Abnormal spontaneous neuronal activities associated with cognitive deficits and emotional dysfunction were found in hypothyroidism. However, routine method employs a relatively broader range of spontaneous fluctuations and would mingle physiological fluctuations contained in specific frequency. In current study we explored how frequency-specific changes of fractional amplitude of low-frequency fluctuations (fALFF) in hypothyroidism. Methods Fifty-three hypothyroid patients and thirty-nine healthy controls (HCs) underwent clinical variables, neuropsychological assessment, and MRI scans. The fALFF in the routine band, slow-4, and slow-5 bands were analyzed. Additionally,Pearsoncorrelation analysis was performed between fALFF and clinical variables and neuropsychological scores in hypothyroid patients. Results Compared to HCs, within the routine band, patients showed significantly decreased fALFF in left lingual gyrus, middle temporal gyrus (MTG), calcarine cortex, precentral gyrus, and right inferior occipital gyrus; within the slow-5 band, the patients exhibited decreased fALFF in left lingual gyrus, MTG, superior temporal gyrus, postcentral gyrus, and paracentral lobule, and increased fALFF in right middle frontal gyrus and supplementary motor area; Additionally, fALFF in the left lingual gyrus within the routine and slow-5 bands were negatively correlated with thyroid stimulating hormone level. Conclusions We found that fALFF in left lingual gyrus and MTG decreased both in routine and slow-5 bands in hypothyroid patients. These might be potential neuroimaging biomarkers of cerebral impairment in hypothyroid patients. Trial registration ClinicalTials. No:ChiCTR2000028966. Registered 9 January, 2020, https://www.chictr.org.cn
Environmental risk evaluation of the transgenic Brassica napus lines harboring serine acetyltransferase gene from Nicotiana tabacum
Authors: Khan Muhammad Sayyar , Qahar Fariha 
Published: August 2023

Abstract
The commercial use of transgenic plants bears great potential in solving many environmental and food problems. However, the potential impact of transgenic plants on peripheral ecosystems has to be assessed before their release for commercial purposes. In this study, we performed environmental biosafety assessments on three independent single and a double overexpression lines harboring serine acetyltransferase (SAT) gene from Nicotiana tabacum (Nt). These lines have been previously demonstrated to confer tolerance against heavy metals (cadmium) and oxidative (hydrogen peroxide) stresses. We did two allelopathy bioassays (sandwich assays) to assess the potential impact of the transformants on the surrounding vegetation. We also surveyed the rhizosphere microbes to assess the potential impact of these transgenic lines on the microbial community (bacteria and fungi). Our data indicated that the transgenic lines are not significantly different from non-transgenic lines in terms of their impact on the surrounding vegetation and the rhizosphere microbe community under greenhouse conditions.
Analysing the chemical composition of sumac gummy candy from Rhus Coriaria (Sumac)
Authors: Jamir Alemsenla , Sibian Mandeep Singh 
Published: August 2023

Abstract
Sumac is the popular name for the genus Rhus, which is a member of the family Anacardiaceae and has over 250 distinct species of flowering plants.Sumac, or Rhus coriaria, is increasingly used in pharmacology, food science, and veterinary medicine, in addition to being used in cooking and human sustenance.In this study, the manufacture of sumac powder and its physicochemical composition of sumac gummy candy were assessed. Additionally, two varieties of sumac gummy candies with different formulations were created.Sumac gummy candies made with 20% agar, 70% sugar, and 190% sumac water in varied ratios of 90% sumac powder with 10% pomegranate juice (for coloring) and 70% sumac powder. Differences in the chemical composition and sensory qualities of the two kinds of candies were analyzed. The Nine-Point Hedonic Scale and Score Card Method were used for sensory evaluation in order to determine the best acceptable product. Based on sensory examination and chemical analysis, the sumac gummy candies (Sample A) received the highest ratings from the panelists for appearance (8.6), color (7.75), texture (8.4), taste (8.1), flavor (8.9), and overall acceptance (8.35). Moisture (32.61), ash (0.26), fat (0.52), protein (0.52), and carbohydrates (66.05) constitute the sumac gummy candy’s physicochemical composition.
FUT1 variants responsible for Bombay or para-Bombay phenotypes in a database
Authors: Soejima Mikiko , Koda Yoshiro 
Published: August 2023

Abstract

Rare individuals with Bombay and para-Bombay phenotypes lack or have weak expression of the ABO(H) antigens on surface of red blood cells due to no or very weak H-type α(1, 2)fucosyltransferase activity encoded byFUT1.These phenotypes are clinically important because subjects with these phenotypes can only accept transfusions of autologous blood or blood from subjects with the same phenotypes due to the anti-H antibody. To surveyFUT1alleles involved in Bombay and para-Bombay phenotypes, the effect of 22 uncharacterized nonsynonymous SNPs in the Erythrogene database on the α(1, 2)fucosyltransferase activity were examined by transient expression studies andin silicoanalysis using four different online software tools. Two nonfunctional alleles (FUT1with 503C > G and 749G > C) and one weakly functional allele (with 799T > C) were identified in transient expression studies, while the software predicted that the proteins encoded by more alleles including these would be impaired. Because both nonfunctionalFUT1alleles appear to link to the nonsecretor alleles, homozygotes of these alleles would be the Bombay phenotype. The present results suggest that functional assays are useful for characterization of nonsynonymous SNPs ofFUT1when their phenotypes are not available.
Adjuvant Chemotherapy Omission after Pancreatic Cancer Resection A French Nationwide Study
Authors: Poiraud Charles , Lenne Xavier , Bruandet Amélie , Theis Didier , Bertrand Nicolas , Turpin Anthony , Truant Stéphanie , AMRANI MEHDI EL 
Published: August 2023

Abstract

Background. Adjuvant chemotherapy (AC) improve the prognosis after pancreatic duct adenocarcinoma (PDAC) resection. However, previous studies have shown that a large proportion of patients do not receive or complete AC. This national study examined the risk factors for the omission or interruption of AC.
Methods. Data of all patients who underwent pancreatic surgery for PDAC in France between January 2012 and December 2017 were extracted from the French National Administrative Database. We considered “omission of adjuvant chemotherapy” (OAC) all patients who failed to receive any course of gemcitabine within 12 postoperative weeks and “interruption of AC” (IAC) was defined as less than 18 courses of AC.
Results. A total of 11 599 patients were included in this study. Pancreaticoduodenectomy was the most common procedure (76.3%), and 31% of the patients experienced major postoperative complications. OACs and IACs affected 42% and 68% of the patients, respectively. Ultimately, only 18.6% of the cohort completed adjuvant treatment. Patients who underwent surgery in a high-volume center were less affected by postoperative complications, with no impact on the likelihood of receiving AC. Multivariate analysis showed that age ≥80 years, Charlson comorbidity index (CCI)≥4, and major complications were associated with OAC (OR=2.19 ; CI95%[1.79-2.68] ; OR=1.75 ; CI95%[1.41-2.18] and OR=2.37 ; CI95%[2.15-2.62] respectively). Moreover, age ≥80 years and CCI 2-3 or ≥4 were also independent risk factors for IAC (OR=1.54, CI95%[1.1–2.15]; OR=1.43, CI95%[1.21-1.68]; OR=1.47, CI95%[1.02-2.12], respectively).
Conclusion. Sequence surgery followed by chemotherapy is associated with a high dropout rate, especially in octogenarian and comorbid patients.
Prognostic value of 18F-FDG PET in uterine cervical cancer patients with stage IIICr allocated by imaging
Authors: Isaji Yuzu , Tsuyoshi Hideaki , Tsujikawa Tetsuya , Orisaka Makoto , Okazawa Hidehiko , Yoshida Yoshio 
Published: August 2023

Abstract
Background
The effect on survival of radiographic lymph node metastasis in uterine cervical cancer patients is more important than before, even though its prognostic value not been well investigated. The aim of our study is to evaluate the prognostic potential of 18F-FDG PET imaging in uterine cervical cancer patients with stage IIICr allocated by imaging.
Methods
Fifty-five patients with biopsy-proven primary cervical cancer underwent definitive radiation therapy for stages IIB–IVB of the 2018 FIGO 2018 classifications. The prognostic performance of pretreatment 18F-FDG PET and CT for assessing lymph node metastasis was evaluated by two experienced readers. The PET and CT findings were correlated with the risk of progression-free survival (PFS) and overall survival (OS).
Results
Kaplan–Meier survival curves showed that PFS was significantly worse in patients with FDG uptake in lymph nodes than in those patients with no FDG uptake (p = 0.003), whereas there was no significant difference in PFS between patients with lymph nodes sized ≥ 1 cm and those sized < 1 cm (p = 0.140). Univariate analysis showed that FDG uptake in lymph nodes was significantly associated with poor PFS (p = 0.006), whereas lymph node size was not significantly associated with poor PFS (p = 0.145). In multivariate analysis, FDG uptake in lymph nodes was significantly associated with poor PFS (p = 0.006) and was an independent prognostic factor for PFS.
Conclusions
18F-FDG PET offers high prognostic value for patients with stage IIICr allocated by imaging, suggesting that 18F-FDG PET might be useful in clinical staging decisions and thus promote optimal diagnostic and therapeutic strategies.
Title: The need for a closer monitoring of novel drugs in MS: a Siponimod retrospective cohort study (Realhes Study)
Authors: Sancho-López Arantxa , Ruiz-Antorán Belén , Hernangómez Teresa Iglesias , Ramírez-García Almudena , Estevez Irene Gomez , Sanabria-Cabrera Judith , Rius Roser Llop , Pedros Consuelo , Campodonico Diana , Jiménez-Jorge Silvia , Luque Amelia García , Costa Lucienne , Montane Eva , Aldea-Perona Ana , Tellez-Lara Nieves , Ferrer Montserrat Bosch , Jimenez Consuelo Rodriguez , Bonilla-Toyos Elvira , Muñoz Julia Sabín , Avendaño-Sola Cristina , Quilez Maria Rosario Blasco 
Published: August 2023

Abstract
Background Severe cases of lymphopenia have been reported during siponimod clinical trials, which may negatively impact its benefit/risk profile.Objective To evaluate the incidence of lymphopenia during the first 3–6 months of siponimod treatment in clinical practice. Secondary objectives include analyses of factors predisposing to and the clinical relevance of lymphopenia events.Methods In this multicenter retrospective cohort study, collected information from the medical records of 129 patients with MS, from 15 tertiary hospitals in Spain, who initiated treatment with siponimod, were followed-up for at least 3 months and had at least one lymphocyte count evaluation.Results Of the 129 patients, 121 (93.6%) reported lymphopenia events, including 110 (85.3%) with grade ≤ 3 and 11 (8.5%) with grade 4 lymphopenia, higher than those reported in the pivotal clinical trial (73.3% and 3.3% for Grade ≤ 3 and Grade 4 lymphopenia, respectively).Conclusion In this study, the incidence and severity of lymphopenia after starting siponimod treatment were higher than those reported in previous clinical trials. Therefore, our results reinforce the need for closer monitoring of novel MS drugs in clinical practice, as well as larger and longer follow up studies to properly characterize this risk.Trial registration EU PAS Register (http://encepp.eu), identifier #EUPAS45187 (January 17, 2022)
Optimization of the extraction of bioactive compounds from Clitoria ternatea L and evaluation of encapsulation by ionotropic gelation
Authors: Santana Bruna Rodrigues , Ribeiro Leomara Floriano 
Published: August 2023

Abstract
The aim of this work was to optimize the extraction of bioactive compounds from Clitoria ternatea L and then to encapsulate them by ionic gelation. The extraction of the bioactive compounds, using water as solvent, was carried out the solid-liquid extractions in cold and hot, obtaining a response factor the content of total phenolic compounds (TPC). The bioactive compounds of the extracts were evaluated based on the levels of TPC and total monomeric anthocyanins. Analyzes of physical, chemical, phytochemical and antioxidant potential were performed. Encapsulation was performed by ionic gelation. The capsules were evaluated by characterization and visual aspects. Simulated gastrointestinal digestibility was determined based on TPC bioaccessibility. There was no statistical difference (p ≤ 0.05) between the extracts. The quadratic mathematical model presented a correction coefficient, R² = 0.997 and R²adjust = 0.974. Hot extraction at 80°C/5 minutes at a concentration of 0.008 g/mL showed a TPC of 23.91 ± 0.90 mg (GAE)/g and 0.97 ± 0.50 mg (MVE)/g for monomeric anthocyanins. For antioxidant potential, the values ​​of ABTS, FRAP and β-carotene/linoleic acid were 84.86 ± 1.52 µM trolox/g, 220.83 ± 3.69 µM ferrous sulfate/g and 55, 95 ± 4.51%, respectively, for the same assay. Visually, the capsules had regular sizes and preserved color, high solubility (99%), encapsulation efficiency (76%). Bioaccessibility was 71% for lyophilized capsules, with greater intestinal absorption. Therefore, extracts and capsules of Clitoria ternatea L. have bioactive compounds with an antioxidant profile.