bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valorization of xylose residues and crude glycerol for production of biopolyurethane foam
Authors: Fu Kai , Zhang Linda , Lin Yucheng , Zhang Weihong , Zhao Zigao , Chen Wei , Chang Chun 
Published: August 2023

Abstract
Currently polyurethane (PU) products are heavily dependent on petroleum resources, highlighting an urgent need to develop new bio-based materials. This study aimed to develop a sustainable method of utilizing low-cost and renewable xylose residues (XR) and crude glycerol (CG) for the production of biopolyols. Optimal synthesis conditions were determined to be 220 °C, 3 h, and 7% sodium hydroxide loading, resulting in biopolyols with a hydroxyl number of 505 mg KOH/g and an acid number of 1.7 mg KOH/g. The obtained biopolyols were used to produce bio-based polyurethane (PU) foams with compressive strength of 225 kPa, density of 0.048 g·cm-3, and thermal conductivity of 0.0355 W·m-1·K-1. Characterization analysis using FT-IR, 1H NMR, and TGA confirmed the excellent thermal stability and insulation properties of the bio-based PU foam. This study provides a valuable method for producing sustainable bio-based PU foam from XR and CG, thereby presenting a novel approach to realizing the high-value utilization of both resources.
Relationship Between Pentraxin 3 and Left Ventricular Diastolic Dysfunction in Patients With Obstructive Sleep Apnea: An Observational Study
Authors: Song Song-song , Ge Tian-tian , Tong Jia-yi , Wang Tao , Xie Liang , Yu Fu-chao , Xu Xuan 
Published: August 2023

Abstract
Purposes:
The purpose of the study was to evaluate the expression and significance of plasma pentraxin 3 (PTX3) in patients with obstructive sleep apnea (OSA) with left ventricular diastolic dysfunction.
METHODS:
We enrolled 90 patients with OSA and 40 patients without OSA as the control group at the same time. We measured plasma PTX3 levels in all patients. All patients underwent polysomnography and transthoracic echocardiography was used to assess diastolic function in all patients.
RESULTS:
Among the 90 patients, 23 had mild OSA and 67 had moderate-to-severe OSA, pentraxin3 levels in the moderate-to-severe OSA group were significantly higher than those in the mild OSA and control groups, with median levels of 3.68, 2.19, and 2.00ng/ml, respectively (p < 0.05). The pentraxin3 levels gradually increased with the aggravation of left ventricular diastolic dysfunction(p < 0.05). The age, systolic blood pressure, AHI, and pentraxin3 were significantly associated with left ventricular diastolic dysfunction with ORs of 1.06 (95% CI = 1.01–1.11), 1.05 (95% CI = 1.00–1.08), 1.06(95% CI = 1.01–1.11), 2.08(95% CI = 1.18–3.66), respectively.
CONCLUSIONS:
Plasma PTX3 levels were significantly increased in OSA patients, and PTX3 was independently associated with left ventricular diastolic dysfunction in OSA patients.
Cetyl Trimethyl Ammonium Bromide (CTAB) functionalized sodium silicate for Naphtol Green B and Congo Red adsorption.
Authors: Fadimatou Ngoungoure Mandou , Fotsing Patrick Nkuigue , Mandjewil Albert , Siewe Jean Mermoz , vieillard julien , Dotto Guilherme , Woumfo Emmanuel Djoufac , Ngueagni Patrick Tsopbou 
Published: August 2023

Abstract
Removal of dyes using optimized and renewable adsorbent with high adsorption capacity remain a challenge. Rice husk was used as a raw material for the manufacture of a new CTAB-functionalized sodium silicate adsorbent. The adsorption capacity of raw rice husk, calcined rice husk (400, 600, 800, and 1000°C), and functionalized sodium silicate with CTAB (Cetyl Trimethyl Ammonium Bromide) was investigated. SEM, FTIR, TGA-DSC and zeta potential characterized the modified rice husks. Adsorption tests were carried out using Naphthol Green B (NGB) and Congo Red (CR) as dyes. Results showed that the calcination temperature influenced the sodium silicate adsorption capacity and enhanced the effect of functionalization by CTAB at 600°C as the optimum calcination temperature. The maximum adsorption capacities of CR and NGB were 73.04 and 86.59 mg g-1, respectively, which were higher than those generally observed in the literature. The optimal adsorption condition was pH of 6, 0.1 g of Na2SiO3-CTAB, 30 min of contact time, and 303K. The desorption using a 50% acetone solution of 0.1g Na2SiO3-CTAB showed a desorption capacity of 96.21 % and 92.32 %, respectively, for CR and NGB. Desorption results show that a combination of hydrogen bonds and Van Der Walls interactions occurred. Four cycles of adsorption/desorption were done, and the desorption rate decreased to 42.23% and 13.93% for CR and NGB, respectively. Thus, it can be concluded that sodium silicate modified with CTAB after calcination at 600°C is a potential low-cost adsorbent and renewable sorbent for the removal of dyes from industrial wastewater.
An Integrated Clinical-radiogenomic Screening Programfor the Identification of Brca 1/2 Carriers: a Cost-effectiveness Analysis (E-probe Study)
Authors: Pilla Andrea Di , Nero Camilla , Specchia Maria Lucia , Ciccarone Francesca , Boldrini Luca , Lenkowizch Jacopo , Alberghetti Benedetta , Fagotti Anna , Testa Antonia Carla , Valentini Vincenzo , Sala Evis , Scambia Giovanni 
Published: August 2023

Abstract
Importance: Current approach to identify BRCA 1/2 carriers in the general population is ineffective as most of the carriers remain undiagnosed. Radiomics is an emerging tool for large scale quantitative analysis of features from standard diagnostic imaging and has been applied also to identify gene mutational status.
Objective: To evaluate the clinical and economic impact of integrating a radiogenomics model with clinical and family history data in identifying BRCA mutation carriers in the general population. Design: This cost-effective analysis compares 3 different approaches to women selection for BRCA testing:
established clinical criteria/family history (model 1)
established clinical criteria/family history and the currently available radiogenomic model (49% sensitivity and 87% specificity) based on ultrasound images (model 2)
same approach used in model 2 but simulating an improvement of the performances of the radiogenomic model (80% sensitivity and 95 % specificity) (model 3).
All models were trained with literature data. Direct costs were calculated according to the rates currently used in Italy.
Setting: The analysis was performed simulating different scenarios on the generation of 18-year-old girls in Italy (274,000 people).
Main Outcome(s) and Measure(s): The main outcome was to identify the most effective model comparing the number of years of BRCA-cancer healthy life expectancy (HLYs). An Incremental Cost-Effectiveness Ratio (ICER) was also derived to determine the cost in order to increase BRCA carriers-healthy life span by one year.
Results: Compared to model 1, model 2 increases the detection rate of BRCA carriers by 41.8%, reduces the rate of BRCA-related cancers by 23.7%, generating over a 62-year observation period a cost increase by 2.51 €/Year/Person. Moreover, model 3 further increases BRCA carriers detection (+ 68.3%) and decrease in BRCArelated cancers (-38.4%) is observed compared to model 1. Model 3 increases costs by 0.7 €/Year/Person. After one generation, the estimated ICER in the general population amounts to about 3,800€ and 653€ in model 2 and model 3 respectively.
Conclusions and Relevance: Model 2 has a massive effect after only one generation in detecting carriers in the general population with only a small cost increment. The clinical impact is limited mainly due to the current low acceptance rate of risk-reducing surgeries. Further multicentric studies are required before implementing the integrated clinical-radiogenomic model in clinical practice.
Reduction of settling time by multi-frequency pulsed parametric excitation
Authors: Ramírez-Barrios Miguel Luis , Dohnal Fadi 
Published: August 2023

Abstract
Introducing a time-periodicity into a system parameter leads to parametric excitation, which in general, may cause a parametric resonance with exponentially increased vibration. Applying the same parametric excitation but carefully tuning its frequencies to multiple parametric anti-resonance frequencies is investigated here. The parametric excitation is an open-loop control at the system boundary that allows for an energy flow into or from the system. A parametric anti-resonance successfully triggers an energy transfer between specific vibration modes of the system and occurs in systems with at least two degrees of freedom. Such an energy transfer increases the overall dissipation of kinetic energy of a lightly damped system. This contribution presents an approach to accelerate the mitigation of transient vibrations by applying a multi-frequency parametric excitation with two or more parametric anti-resonance frequencies. The potential application in a MEMS sensor arrangement consisting of two and more coupled flexible beams exemplifies the method. Starting from the minimum system with two degrees of freedom, the averaging method is applied to analyze the transient slow flow of the underlying physical system. This procedure allows for an analytical approximation of the transition time of a pulsed multi-frequency parametric excitation. For a specific example, a reduction of 96.7% of the transient vibrations is achievable.
Genetic causality between type 1 diabetes and arrhythmia: a two-sample Mendelian randomization study
Authors: Liu Yudi , Rao Jin , Hu Wei , Zhang Yufeng , Yu Yue , Wang Pei , Chen Xiangyu , Wang Zhinong 
Published: August 2023

Abstract
Background
Clinical studies have shown that cardiovascular diseases in patients with type 1 diabetes (T1D) are often atypical or asymptomatic. While diabetic cardiomyopathy has been confirmed, the link between T1D and arrhythmia remains unclear. To infer causality between T1D and arrhythmia at the genetic level, we conducted a Mendelian randomization study through the genetic tools of T1D.
Methods
In this study, we used genetic variables and summary statistics from genome-wide association studies (GWAS) of type 1 diabetes (T1D) and arrhythmia. Single nucleotide polymorphisms (SNPs) were selected based on the assumptions of instrumental variables (IVs). The inverse variance-weighted (IVW) method was used as the primary analysis to summarize the causal effects between exposure and outcome. The weighted median and weighted mode methods were used as secondary methods. We tested for horizontal pleiotropy using the MR-Egger method and detected heterogeneity using the Q-test. A leave-one-out sensitivity analysis was performed. Scatter plots, forest plots, and funnel plots were used to visualize the results of the MR analysis.
Results
In this study, we selected 28 T1D-related SNPs as instrumental variables. The IVW [odds ratio (OR) = 0.98, 95% confidence interval (CI) = 0.97 − 1.00, P = 0.008], weighted median (OR = 0.98, 95% CI = 0.96 − 0.99, P = 0.009), and weighted mode (OR = 0.98, 95% CI = 0.96 − 0.99, P = 0.018) analysis methods suggested a causal effect of T1D on arrhythmia. The MR-Egger method indicated no horizontal pleiotropy (P = 0.649), and the Q-test showed no heterogeneity (IVW, P = 0.653). Sensitivity analysis indicated that the MR analysis results were robust.
Conclusions
Our MR analysis revealed a causal association between T1D and the development of arrhythmia, indicating that patients with T1D had a higher risk of arrhythmia.
CircRNA_0044556 regulates paclitaxel resistance in triple-negative breast cancer by targeting miR-665
Authors: chen jingjing , shi peng , cui zhiqiang , jiang nan , ma jie , zhang jinghua 
Published: August 2023

Abstract
Background
CircRNAs have been significantly implicated in the development and resistance of triple-negative breast cancer (TNBC). However, the association between circRNA_0044556 and TNBC paclitaxel (PTX) resistance is still limited. Therefore, the purpose of this study was to investigate the effect of circRNA_0044556 on the biological function and PTX resistance of TNBC cells.
Methods
PTX-resistant TNBC cells (MDA-MB-231/PTX) were obtained by continuously exposing MDA-MB-231 cells to increased paclitaxel levels. First, the expression levels of circRNA_0044556 and miR-665 were measured by qRT‒PCR. Then, the regulatory relationship between miR-665 and circRNA_0044556 was verified by biological information website analysis and double luciferase reporter gene detection experiments. Finally, MTT assay, clonogenesis assay, flow cytometry and Western blot analysis were used to evaluate the influence of cell biological function.
Results
Elevated circRNA_0044556 was present in TNBC, and paclitaxel increased the expression of circRNA_0044556 in TNBC cells. In TNBC, circRNA_0044556 acts as a ceRNA for miR-665. In addition, low expression of circRNA_0044556 combined with miR-665 inhibited the proliferation of TNBC cells and paclitaxel-resistant TNBC cells while inducing cell death.
Conclusions
Our study demonstrated that downregulation of circRNA_0044556 inhibited the malignant progression of TNBC cells and paclitaxel resistance via miR-665. Thus, circRNA_0044556 may be a potential therapeutic target for TNBC paclitaxel resistance.
Photo- and pH-dually responsive hydrogel containing spirooxazine groups
Authors: 邹 钰龙 , Zou Yulong , Gao He , Su Chengdong , Wang Min , Gao Jun 
Published: August 2023

Abstract
The development of a low-cost and multifunctional sensing and monitoring device would be a meaningful endeavor. In this research, a novel spirooxazine with a double double-bonded structure, designated as (1-butyl-3,3-dimethylspiro[indoline-2,3'-naphtho[2,1-b][1, 4]oxazine]-5,8'-diyl)bis(methylene)bis(2-methylacrylate) (SO-DB), was successfully synthesized and incorporated as a functional cross-linker into a polyhydroxyethyl methacrylate hydrogel system. Notably, this hydrogel system based on a single responsive component exhibits photo-pH dual responsiveness, which avoids the addition of multiple components that may affect other properties of the hydrogel. Particularly, in comparison to traditional surface grafting and physical blending, crosslinking with SO-DB leads to the formation of a denser and stronger three-dimensional polymer network in the stimuli-responsive hydrogel. Under UV light irradiation, spiropyran absorbs energy and undergoes cleavage of the Cspiro-O bond, transforming the molecule from a colorless closed-ring state to an open-ring PMC state. Under acidic conditions, hydrophobic spirooxazine undergoes a reversible protonation open-ring reaction, forming a stable intermediate form (PMCH). Furthermore, the addition of SO-DB as a crosslinking agent to the hydrogel system increases its stability and fatigue resistance, and maintains good repeatability over 24 light cycles and 7 pH cycles without performance loss. Such approach to generate stimulus-responsive hydrogels could have great potential in both wearable biosensors and food packaging field.
NDR-UNet: Segmentation of Water Bodies in Remote Sensing using Nested Dense
Authors: Surekha Jonnala Naga , gupta neha 
Published: August 2023

Abstract
The identification and accurate delineation of water bodies in remote sensing satellite images have significant implications for scientific research and various applications such as natural disaster forecasting, drought and flood detection, and monitoring disappearing water bodies. However, this task poses challenges due to complex spectral variations caused by factors like aquatic vegetation, different colors of lakes/rivers, mud along the sand, and shadows from surrounding plants. To address these challenges and improve water body extraction from high-resolution and moderate high-resolution remote sensing images, we propose a method called D3net (Nested Dense Residual Network). The Adam optimizer is employed to train the satellite images, minimizing the associated losses. The activation function and the number of nodes in each layer are optimized to achieve the best performance. To ensure data integrity and protect the identified water bodies during transmission, we utilize the Elliptic Curve Digital Signature Algorithm as a security component. This algorithm creates a digital signature for the projected area of water bodies, providing data protection. For our study, we used a dataset consisting of 5682 Sentinel-2 satellite images, including 2841 images and their corresponding masks. The masks were generated using the Normalized Water Difference Index (NWDI) for a specific geographic location in Europe. The suggested model achieves a performance IOU (Intersection over Union) of 93.27% and a recall rate of 95.60%. Additionally, the model can be applied to tasks such as edge detection, blurry image recognition, and low resolution image detection. It exhibits reliability and accuracy in its predictions, although it may require more memory due to the utilization of high-resolution and moderate high-resolution images for segmentation.
Soil Remediation, Waste Valorization and Biofuels from Cement Kiln Dust Landfills
Authors: Zeman Frank , Ghazizade Maryam , Ellis Colton 
Published: August 2023

Abstract
Bioenergy is viewed as a potential solution to anthropogenic greenhouse gas emissions. A sustainable deployment will depend on targeting marginal lands, particularly brownfield and degraded lands. In contrast, industrial remediation is often uneconomical or even desirable, especially if degraded lands passively return to a nature like state. Cement kiln dust landfills, containing saline solids, are such degraded lands that can be remediated biologically. Phytoremediation uses plants to transport a pollutant from contaminated soil into standing biomass. After harvest, it can be processed to separate salt, biofuel and process water. Work showed that salt recovery was preferential for large liquid to solid ratios with little effect for longer durations and higher temperatures. Elevated temperatures require additional energy while co-leaching more biomass, thus reducing total biomass to the kiln. Repeated soaking of smaller volumes of room temperature water also led to effective recovery. A multi stage design was investigated to reduce water consumption. The three stage counter current soaking method produced similar recovery while consuming 25% less water. The product is biomass with sufficient energy density for use as a solid fuel in the cement kiln at a carbon price below $20/t CO2. Long term remediation of cement kiln dust stockpiles is feasible on the century time scale while producing biofuel for the cement plant. Each square kilometer planted can substitute 5% of a cement kiln’s fuel while returning the waste to the kiln. This represents an early opportunity for combined remediation, waste valorization and bioenergy.
Emerging Threats in Urinary Tract Infections: Unveiling Antimicrobial Susceptibility and Resistance Patterns of Developed Extended-Spectrum Beta-Lactamases Producing E. coli.
Authors: Mansoor Noor us Saba , Dilshad Huma , Sheikh Javeria 
Published: August 2023

Abstract
Background and Objective of the Study:
The main aim of the study was to assess antimicrobial susceptibility and resistance developed by extended-spectrum beta-lactamase (ESBL)-producing E. coli. responsible for causing urinary tract infections and to identify effective antibiotic choices in these organisms.
Method
A cross-sectional retrospective study was conducted in which 200 clinical uropathogenic E. coli isolates were gathered and screened for antimicrobial resistance by the Kirby buyer method and confirmation testing for identifying ESBL producers was performed by a double disc synergy test.
Results
This study shows that females (82%) and adults (50%) are more prone to such infections because of different anatomical and behavioral changes. Antibiotics such as imipenem, amikacin, fosfomycin, and tazobactam/piperacillin exhibit 98.5%, 91.0%, 84.5% and 86% sensitivity patterns against collected E. coli isolates; hence, they can be the preferred choice of treatment against UTIs caused by E. coli. Forty-six percent of isolates out of 65 were found to be multidrug resistant. Fifty-five percent (107) of isolates were identified as ESBL producers after initial screening through an antimicrobial susceptibility test and were further confirmed as 60.7% (65) isolates positive for ESBL producers and 39.2% (42) negative for ESBL producers by a double disc synergy test. A statistically significant correlation was found between the MDR/non-MDR profile and the ESBL-negative/positive profile, as its p value was found to be 0.000, which is less than 0.05.
Interpretation and Conclusion:
It was concluded that although E. coli has developed resistance against many drugs, there are certain antibiotic choices that can be considered while prescribing. Females and adults are more prone to these infections and must be sufficiently educated to avoid them.
Prediction of Porosity, Hardness and Surface Roughness in Additive Manufactured AlSi10Mg Samples
Authors: Alamri Fatma , Maalouf Maher , Barsoum Imad 
Published: August 2023

Abstract
Despite the advantages of additive manufacturing, its widespread adoption is still hindered by the poor quality of fabricated parts. Using advanced machine learning techniques to predict part quality can improve repeatability and open up additive manufacturing to a wider range of industries. This study aims to accurately predict the relative density, surface roughness, and hardness of AlSi10Mg samples produced by selective laser melting with respect to process parameters such as scan speed, layer thickness, laser power, and hatch distance. For this purpose, data including porosity, surface hardness, and roughness were extracted from the literature and additional measurements were conducted on additive manufactured samples in the current work. In this work, five supervised machine learning algorithms are compared including; artificial neural network, support vector regression, kernel ridge regression, random forest, and Lasso regression. These models are evaluated based on the coefficient of determination and the mean squared error. Based on the computational results, artificial neural network outperformed in predicting relative density, surface roughness and hardness. Feature importance analysis on the compiled dataset using ANN revealed that laser power, and scan speed are the most important features affecting relative density (e.g., porosity) and hardness, while scan speed and layer thickness significantly impact the surface roughness of the parts. The study identified an optimal laser power and scan speed region that achieves a relative density > 99%, surface roughness < 10 µm, and hardness > 120 HV. The outcomes presented in this study provide significant advantages for additive manufacturing, potentially reducing experimentation costs by identifying the process parameters that optimize the quality of the fabricated parts.