bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Spinal Needle Sizes Affect the Development of Traumatic CSF in Neonatal LP Procedures?
Authors: Orman Aysen , Aydın Hilal 
Published: March 2023

Lumbar puncture (LP) is widely employed to evaluate infectious, neurological and metabolic diseases in the newborn. Neonatal LP is a difficult procedure with 45–54% success rates. Although there are studies examining traumatic LP failure, studies on the effects of needle sizes are limited. This study was intended to investigate the effect of needle sizes on LP traumatization. Term and premature babies who underwent LP in the neonatal intensive care unit between 30 November 2017 and 30 July 2019 were included in the study by retrospective file scanning. LP was performed by a pediatric or neonatal specialist using a 22 Gauge pen (G) or 25 G pen spinal needle in all cases, with all patients being placed in the lateral decubitus position. The primary outcome was to evaluate the effect of needle sizes used in LP on traumatization. The secondary outcome was to evaluate traumatization rates and complications. A statistically significant difference was determined in the rate of traumatized LP and desaturation development between needle sizes and CSF microscopic findings (p = 0.031, p = 0.005, and p = 0.006, respectively). The study data show that 25 G pen-tip spinal needles cause less traumatic LP in neonates than 22 G pen-tip spinal needles.
Antibacterial and Immunostimulatory Activity of Potential Probiotic Lactic Acid Bacteria Isolated from Ethiopian Fermented Dairy Products
Authors: Gizachew Seyoum , Van Beeck Wannes , Spacova Irina , Dekeukeleire Max , Alemu Ashenafi , Woldemedhin Wude Mihret , Mariam Solomon H. , Lebeer Sarah , Engidawork Ephrem 
Published: March 2023

Lactic acid bacteria (LAB) form a group of bacteria to which most probiotics belong and are commonly found in fermented dairy products. Fermented foods and beverages are foods made through desired microbial growth and enzymatic conversions of food components. In this study, 43 LAB were isolated from Ethiopian traditional cottage cheese, cheese, and yogurt and evaluated for their functional and safety properties as candidate probiotics. Twenty-seven isolates, representative of each fermented food type, were selected and identified to the species level. Limosilactobacillus fermentum was found to be the predominant species in all samples studied (70.4%), while 11.1% of isolates were identified as Lactiplantibacillus plantarum. All 27 isolates tested showed resistance to 0.5% bile salt, while 26 strains were resistant to pH 3. The LAB isolates were also evaluated for antagonistic properties against key pathogens, with strain-specific features observed for their antimicrobial activity. Five strains from cottage cheese (Lactiplantibacillus plantarum 54B, 54C, and 55A, Lactiplantibacillus pentosus 55B, and Pediococcus pentosaceus 95E) showed inhibitory activity against indicator pathogens that are key causes of gastrointestinal infections in Ethiopia, i.e., Escherichia coli, Salmonella enterica subsp. enterica var. Typhimurium, Staphylococcus aureus, Shigella flexneri, and Listeria monocytogenes. Strain-specific immunomodulatory activity monitored as nuclear factor kappa B (NF-κB) and interferon regulatory factor (IRF) activation was documented for Lactiplantibacillus plantarum 54B, 55A and P. pentosaceus 95E. Antibiotic susceptibility testing confirmed that all LAB isolates were safe concerning their antibiotic resistance profiles. Five isolates (especially Lactiplantibacillus plantarum 54B, 54C, and 55A, Lactiplantibacillus pentosus 55B, and P. pentosaceus 95E) showed promising results in all assays and are novel probiotic candidates of interest for clinical trial follow-up.
A Novel Quantum Dots-Based Fluorescent Sensor for Determination of the Anticancer Dacomitinib: Application to Dosage Forms
Authors: Alossaimi Manal A. , Elmansi Heba , Alajaji Mai , Altharawi Ali , Altamimi Abdulmalik S. A. , Magdy Galal 
Published: March 2023

One of the most promising drugs recently approved for the treatment of various types of cancer is dacomitinib, which belongs to the tyrosine kinase inhibitor class. The US Food and Drugs Administration (FDA) has recently approved dacomitinib as a first-line treatment for patients suffering from non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The current study proposes the design of a novel spectrofluorimetric method for determining dacomitinib based on newly synthesized nitrogen-doped carbon quantum dots (N-CQDs) as fluorescent probes. The proposed method is simple and does not require pretreatment or preliminary procedures. Since the studied drug does not have any fluorescent properties, the importance of the current study is magnified. When excited at 325 nm, N-CQDs exhibited native fluorescence at 417 nm, which was quantitatively and selectively quenched by the increasing concentrations of dacomitinib. The developed method involved the simple and green microwave-assisted synthesis of N-CQDs, using orange juice as a carbon source and urea as a nitrogen source. The characterization of the prepared quantum dots was performed using different spectroscopic and microscopic techniques. The synthesized dots had consistently spherical shapes and a narrow size distribution and demonstrated optimal characteristics, including a high stability and a high fluorescence quantum yield (25.3%). When assessing the effectiveness of the proposed method, several optimization factors were considered. The experiments demonstrated highly linear quenching behavior across the concentration range of 1.0−20.0 μg/mL with a correlation coefficient (r) of 0.999. The recovery percentages were found to be in the range of 98.50–100.83% and the corresponding relative standard deviation (%RSD) was 0.984. The proposed method was shown to be highly sensitive with a limit of detection (LOD) as low as 0.11 μg/mL. The type of mechanism by which quenching took place was also investigated by different means and was found to be static with a complementary inner filter effect. For quality purposes, the assessment of the validation criteria adhered to the ICHQ2(R1) recommendations. Finally, the proposed method was applied to a pharmaceutical dosage form of the drug (Vizimpro® Tablets) and the obtained results were satisfactory. Considering the eco-friendly aspect of the suggested methodology, using natural materials to synthesize N-CQDs and water as a diluting solvent added to its greenness profile.
Optimasi Portofolio Saham Syariah Menggunakan Model Indeks Tunggal dan VaR Berbasis GUI Matlab
Authors: Abdjul Lindrawati , Resmawan Resmawan , Nuha Agusyarif Rezka , Nurwan Nurwan , Wungguli Djihad , Nashar La Ode 
Published: March 2023

Sharia-based investment is an investment by the community to obtain profits in accordance with Islamic principles and law. This study aims to calculate the optimal portfolio return value using the Single Index Model, calculate risk with VaR (Value at Risk), and then implement it with Matlab’s GUI (Graphical User Interface). The data used is closing stock price data on the JII (Jakarta Islamic Index) using 30 stocks for two consecutive years. Furthermore, these stocks are selected which have a positive average return value. The study results show that 14 stocks are candidates for optimal portfolios with positive return values, namely: ACES, ADRO, ANTM, BRPT, BTPS, CTRA, EXCL, INCO, MDKA, MNCN, SCMA, TPIA, UNTR, and WIKA. Then the optimal portfolio of the 14 stocks is determined using the Single Index Model considering the ERB (Excess Return to Beta) value ≥ cut-off point value (C*). Based on the value, 4 shares were obtained that belong to the optimal portfolio, namely: MDKA, BRPT, BTPS, and ANTM. Furthermore, VaR calculations are performed on the 4 optimal portfolios to obtain optimum VaR consistency values with 500 repetitions. The VaR calculation results with a 95% confidence level show that the average VaR result is in the range of -0.14704 to -0.3420 so that when investors invest in 4 optimal stocks, the losses experienced by investors are no more than 34%.
Prueba de razonamiento clínico script
Authors: Echeverry-Díaz Tatiana , Restrepo Escobar Jorge Alberto 
Published: March 2023

En medicina interna, una de las principales competencias es la adquisición de toma de decisiones clínicas. Para esto el personal en formación reorganizan sus conocimientos, con el fin de llevar a cabo de manera óptima sus funciones clínicas (diagnóstico, métodos de investigación y conductas terapéuticas), las cuales se organizan en guiones de enfermedad; esto se desarrolla con la experiencia y se adquiere durante su formación académica. Se ha descrito como un innovador instrumento de evaluación la prueba de concordancia de guiones que fue diseñada para evaluar, además de la riqueza de conocimientos, la toma decisiones clínicas: el razonamiento clínico. La teoría del guión entendida como la organización del conocimiento es la base de la toma de decisiones. Los guiones de enfermedad desempeñan un papel clave en el apoyo y desarrollo de las habilidades de razonamiento clínico, el cual se debe adquirir con el fin de generar diagnósticos diferenciales e interpretar datos clínicos
La teoría del guion entendida como la organización del conocimiento, es la base de la toma de decisiones. Los guiones de enfermedad desempeñan un papel clave en el apoyo y desarrollo de las habilidades de razonamiento clínico; este se debe adquirir con el fin de generar diagnósticos diferenciales e interpretar datos clínicos.
Manifestaciones gastrointestinales de la COVID-19 en una población colombiana
Authors: Rodriguez Criollo Jairo Alonso , Otero Regino William Alberto , Ruiz Morales Oscar Fernando , Peñaloza Cruz Fernando , Bastidas Riascos Melissa del Rosario , Gallego Ospina Daniel Mauricio , Gómez Tobar Juan Esteban , Rodríguez Fajardo Darlenne Paola , Rodríguez Criollo Carlos Ernesto , Maya Caicedo Luisa Alejandra , Araujo Ana María , Aragón Martin Natalia Jazmín , Gómez-Arévalo Juan Pablo 
Published: March 2023

Trabajo Ganador del Premio en la Categoría Trabajo de Investigación Clínica o Básica en Medicina del Adulto. Concurso Trabajos Científicos del XXVII Congreso Colombiano de Medicina Interna, Bucaramanga, 10-13 de agosto 2022
Introducción: El compromiso gastrointestinal en COVID-19 se presenta en el 20% de los pacientes aproximadamente y puede incluir nauseas, vomito, dolor abdominal, diarrea o alteración del perfil hepático. En nuestro país, no se han estudiado las características del compromiso gastrointestinal en los pacientes con COVID-19.
Objetivos: Determinar la prevalencia de compromiso gastrointestinal y hepático en pacientes con COVID-19 atendidos en dos hospitales de Bogotá, Colombia. Determinar la asociación del compromiso gastrointestinal por COVID-19 con estancia hospitalaria, severidad y mortalidad.
Diseño y metodología: Estudio de corte transversal, realizado en dos hospitales de una subred hospitalaria de Bogotá, Colombia, entre febrero del 2020 y marzo del 2021.
Resultados. Se incluyeron 1176 pacientes con RT-PCR (reverse transcription polymerase chain reaction) positiva. Las manifestaciones gastrointestinales se presentaron en el 50% (IC95% 47-52%), las más frecuentes fueron diarrea en el 18,4%, odinofagia 17,6%, anorexia 14.7% y dolor abdominal en el 8,8%. Se demostró asociación de la diarrea durante la hospitalización con hospitalización prolongada (OR 1.93 IC95% 1.19-3.13), sangrado gastrointestinal al ingreso con mortalidad (OR 3.13, IC95% 1.1-9.1), entre otros. Las alteraciones del perfil hepático se presentaron en el 46% (IC95% 43-49%), siendo mayor en pacientes con enfermedad grave o mortalidad.
Conclusiones: La prevalencia de las manifestaciones gastrointestinales en pacientes con COVID-19 fue de 50%. La diarrea se asoció a mayor estancia hospitalaria, el sangrado gastrointestinal se asoció a falla ventilatoria y mortalidad. El 46% de los pacientes presentaron alteración del perfil hepático, siendo la elevación de transaminasas lo más frecuente. Se demostró que la elevación de la aspartato aminotransferasa (AST) desde el ingreso se asocia a mayor mortalidad.
Navigation Learning Assessment Using EEG-based Multi-Time Scale Spatiotemporal Compound Model
Authors: Wang Lingling , Liu Yixin , Li Yiqing , Chen Renxiang , Liu Xiaohong , Fu Li , Wang Yao 
Published: March 2023

<p> This study presents a novel method to assess the learning effectiveness using Electroencephalography (EEG)-based Multi-Time Scale Spatiotemporal Compound Model (MTSC). Due to the evaluation of navigation learning, which is centered on the practice innovation ability devel?opment, it is difficult to assess the learning effectiveness in cultivating students’ ability objectively by questionnaire or other assessment methods. Research in the field of brain science has shown that innovation ability can be reflected from cognitive ability which can be embodied by EEG signal features. Therefore, a navigation learning assessment method was applied to detect the cognitive training traces by EEG-based MTSC. To verify the validity of the method, three navigation missions with increasing cog?nitive difficulty were designed, and 41 participants attended the experiment. The features of participants’ EEG signals were extracted and classified by MTSC. Comparing the results between experimental group and control group, it can be seen that MTSC can effectively distinguish the cog?nitive training traces of students in the navigation problem?solving process. In addition, MTSC achieved 89.2% accu?racy and 0.883 F1-Score on features classification, which had an average improvement of 15.7% over other three tra?ditional EEG classification models in accuracy. The results indicate that the navigation learning assessment method provides a useful evaluation approach for learning effec?tiveness using EEG-based MTSC. </p>
Shakespeare Disintegrated: Authoriality, Textuality, Co-Authorship, Biography
Authors: Pugliatti Paola 
Published: March 2023

The article explores one of the most assiduously researched topics in Shakespeare criticism: that of the ways in which Shakespeare’s responsibility as author of the plays that traditionally bear his name has been established. Rehearsing the major contributions to this debate (from the mid-nineteenth-century idea that Shakespeare’s plays were the work of a group of intellectuals, to recent tendencies in attribution studies which dismember the canon on the basis of theories of co-authorship and collaboration), it maintains that one of the most persistent tendencies in the debate has been that of disintegration; and that both the dismembering of the canon as a whole and the amputating of parts of it as collaboratively written have had the paradoxical effect of de-authorialising what are conventionally known as ‘Shakespeare’s plays’.Not simply meant as a historical survey, the article also highlights the fact that, as well as determining effects on the Shakespeare canon, disintegrative tendencies have inspired theories of the text relevant to the construction of authorial identity, and have also generated a fallout on the idea, expressed by bibliographers and textual scholars, that the composition and configuration of texts are inescapably collaborative. Finally, the article maintains that biography too has been affected by a notion of disintegration which insists on a de-personalised subject and the idea that a life, no less than a text, is a socially-composed construct.
John Faed, 'Shakespeare and the King's Men' (1851). Public Domain
Peran Vitamin D terhadap Pertumbuhan Tulang pada Balita
Authors: Febrianto Sazali , Bahari Apriadi 
Published: March 2023

Vitamin D is a fat-soluble vitamin and contains a steroidal molecular structure that is needed for various metabolic processes in the body. There are two sources of vitamin D, namely through manufacture in the skin and the impact of food intake. Vitamin D is divided into 2 forms, namely vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), vitamin D is also actively involved in bone formation, resorption, mineralization, and maintenance of neuromuscular function. Vitamin D deficiency has been widely known to affect linear growth from infants, toddlers to adults. The design of this research is the literature of research articles collected by means of computer searches through google schoolar and repository. Screening can be monitored so that bone growth in toddlers can be optimized properly and correctly.
Peran Filsafat Pendidikan sebagai Fondasi Transformasi Kesehatan
Authors: Pauzi Iswari , Sarjan Muhammad , Muliadi Agus , Azizi Asrorul , Hamidi Hamidi , Yamin Muhammad , Muttaqin Muh. Zaini Hasanul , Ardiansyah Bakhtiar , Rahmatiah Rindu , Sudirman Sudirman , Rasyidi Mulia , Khery Yusran 
Published: March 2023

The purpose of educational philosophy is to inspire how to organize an ideal learning process. Educational theory aims to generate ideas about educational policies and principles based on educational philosophy. Philosophy of education is a philosophical that studies the nature of implementation and tries to answer questions about educational policy, human resources, curriculum and learning theory and other aspects of education that start with questions about what, why and how, which is the main basis of philosophy. In facing the era of globalization and digitalization, the Ministry of Health has made policies to implement Health Transformation, including; Transformation of human resources by establishing new study programs, transformation of health service facilities and infrastructure, transformation of health services and transformation of new communicable diseases. From the results of this study, philosophy has an important role in supporting the transformation of health.
Assessment of Mothers Education and their Knowledge about Home-Accident among Early Childhood Age Group
Authors: Abed Mohammed Talib , Aldoori Nuhad Mohammed 
Published: March 2023

Objectives: The study was carried assessment of mothers education and their knowledge about home accidents prevention among early childhood age group.
Methodology: A descriptive study design was achieved in 10-30 October 2015. A non-probability accidental sample of 113 Mothers who agreed to participate in the study & have a child or more live together at the same house and the sample was selected of health centers when visiting for certain follow-up to their children in the Babylon city, middle of Iraq, Through using questionnaire that constructed by researchers to collect data available for the purpose of the study through using descriptive and inferential statistics according to the aims of the study.
Results: After completion of 113 questionnaire, the results were revealed that majority of mother's age were 44 (38.9%) aged between 22-28 years old while their education were 58 (51.3) in primary level, for this reason the majority of the sample 96 (85%) were unemployed. The study reveals more than quarter of the sample 39.8% as 45 within group of 61-70 score of moderate knowledge with optimum level contrasted.
Conclusions: The present study reveals quarter of the sample had moderate knowledge with optimum level contrasted and few of them have poor knowledge regarding to accidents avoidance of kids under five as well as no correlation between mother's knowledge with their age and education.
Recommendations: Health education program about explanations for home accidents, medical aid managements and technique for avoidance into the educational modules at various levels were recommended.
Effectiveness of Simulation Techniques on the Nursing Students Knowledge toward Cardiopulmonary Resuscitation for Adults at College of Nursing/University of Baghdad
Authors: Abdulwahhab Musaab Majid 
Published: March 2023

Objectives: The study aims to find out the effectiveness of simulation on the students knowledge toward Cardiopulmonary resuscitation for adults
Methodology: a quasi-experimental design study with pre test , post test 1 and post test 2 were conducted to identify the effectiveness of simulation on the students knowledge toward Cardiopulmonary resuscitation. The study starting from November 10th 2014 to the May 10th 2015 on 75 students at 4th years in the College of Nursing / University of Baghdad , the instrument was consist of the Australian guide for Cardio-pulmonary resuscitation , the instrument consist of 20 questions that measure the Basic and advance life support, the reliability of the study was measured through test retest method = 0.85, the researcher use the descriptive and inferential statistics to analyze data
Results: differences in the mean among the pre test , post test 1 and post test 2 were calculated by using Paired Samples T-test , the results show a highly statistical significant differences (p 0.001), the mean (23.186, 49.880 and 52.5867) for pre test , post test 1 and post test 2 respectively show a a marked increase in the knowledge of students toward Cardio-pulmonary resuscitation
Conclusion: the study conclude that a significant increase in the students knowledge were found when using a high-fidelity Cardiopulmonary Resuscitation (CPR) Simulation in the training of the students.
Recommendations: according to the findings of the study the researcher recommend to provide and use a high fidelity simulation in the students training.
Association between Nutrient Contents of Foods and Occurrence of Breast Cancer, A Case Control Study
Authors: Salai Jangi Shawkat , Jawzali Jwan Ibrahim 
Published: March 2023

Objective: The study conducted to identify association of nutrient contents of foods with occurrence of breast cancer compares to control group.
Design: It is descriptive (analytic case-control study). Interview questionnaire was used to collect data of; socio-demographic properties, reproductive history, familial cancer history, and life style factors included indices of obesity, and diet history data to calculate intake of; energy, macronutrient, vitamins and minerals by quantitative food frequency questionnaire.
Methodology: The study included (59) women with diagnosed breast cancer, and (65) controls women free from all types of cancer attending Rizgary and Hawler teaching hospital / Erbil / Iraq , from the period of 1st April to 30 July 2011. Statistical analysis included Descriptive statistic, and logistic regression analysis
Results: The results showed significant increase in the risk of breast cancer by; low income and low awareness, family history of cancer, and higher intake than controls of; energy, digestible and high glycemic load carbohydrates, saturated fats, cholesterol, vitamins; thiamin, and cholecalciferol and minerals; phosphors, sodium zinc, manganese, and selenium. While primary education level act as significant protective factor in addition to slight protective effect of; vitamins K (naphthoquinones), insoluble fiber and (beans and tea) as foods.
Conclusion: High dietary intake of rich energy nutrients, and salty foods could cause; oxidative stress , hormone disturbance and associate with breast cancer risk . Low and safe levels of dietary micro-nutrients and their blood homeostasis may decrease tissues damage and risk of breast cancer.
Recommendations: The study recommended implementation nutritional status assessment and nutritional educational program by nutritional specialized nurses, and nutritionists.