bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAIN FACTORS OF THE NEGATIVE IMPACT OF THE COVID-19 PANDEMIC ON MENTAL HEALTH OF CHILDREN
Authors: Hozak S.V. , Yelizarova O.T. , Stankevych T.V. , Parats A.N. 
Published: January 2023

Relevance. It is widely recognized that COVID-19 disease is significant problem for public health. The COVID-19 pandemic evolves, the long-term health impacts are continually increasing and children health is particular concern. The duration of exposure, heterogeneity and plurality of biopsychosocial factors have to unpredictable consequences on the mental health of vulnerable populations such as children and adolescents.
Objective. Determination the significant factors affecting the mental health of schoolchildren during the pandemic in order to further develop the health-saving measures.
Methods. During implementation of quarantine measures due to COVID-19 pandemic, we studied the peculiarities of schoolchildren’s life and mental health in 2020-2021 (n=1393) from all regions of Ukraine. Q-RAPH, GPAQ, RCADS-P-25 questionnaires were used. Prior to the pandemic, MH survey of 500 schoolchildren was conducted using “Children’s Neuroses Questionnaire” method. Descriptive statistics, Student's coefficients, univariate and multivariate analysis of variance, followed by a posteriori estimation of mean differences according to the Bonferroni test, conjugation tables, logistic and linear regression models were used.
Results. Сonstant stay in an apartment during quarantine leads to an increase in the chances of anxiety-depressive disorders on average by 2.5 times. During the pandemic for the observation period, both duration and frequency of walks were significantly lower for the children with mental disorders. The likelihood of pathological increases in anxiety and depression in school age children without interactive learning is 1.8 times greater. Pairwise comparisons of adjusted means using the Bonferroni test demonstrated that the higher is the BMI - the shorter is the sleep (β=-1.9; p=0.004), the longer is the sedentary behavior duration (β=3.4; p=0.001) - the shorter is MVPA (β =-1,4; p=0,005). It was established that depressive disorders are 2.4 times more common among the children with chronic diseases than among the healthy children (χ2 =51.1; p<0.001). In the course of 3d linear modeling of normalized indicators we can see that a decrease in both light physical activity (LPA) and MVPA leads to deterioration in mental health indicators of the children.
Conclusions. Main factors of the negative impact on children's mental health during the COVID-19 pandemic are: permanent stay at home (OR=2.02; CI 1.39-2.93), frequency of walks less than 4 times a week and duration less than 220 minutes per week (OR=1.96; CI 1.12-3.45), non-interactive remote learning (OR=1.78; CI 1.17-2.69), overweight and obesity of schoolchildren (OR=1 .52; CI 1.11-2.08), presence of chronic diseases (OR=2.79; CI 1.99-3.91), anxiety disorders in parents (OR=3.67; CI 1.02-13,25) and their lack of higher education (OR=1,27; CI 1,03-1,56).
The obtained results must be taken into account when developing further preventive strategies and tactics for overcoming the pandemic consequences.
Pengaruh Kualitas Layanan ISP-S Pada Kepuasan Mahasiswa Terhadap Perkuliahan Daring Masa Pandemi COVID 19 – Mix Method SERVPERF dan ICT
Authors: Prawesty Nurya , Izzudin Muhammad Andik , Permadi Andhy 
Published: January 2023

Internet menjadi hal yang diminati masyarakat dengan fakta kenaikan pengguna pada tahun 2020 sekitar 73,7%. Menurut APJII salah satu penyebab peningkatan pengguna internet karena kebutuhan yang menyebabkan segala proses tatap muka diubah menjadi tatap maya dampak pandemi COVID 19. Hal itu berdampak terhadap segala bidang tidak terkecuali dunia pendidikan. Namun fakta lain yang terjadi menjelaskan peningkatan pengguna internet juga beriringan dengan tingginya keluhan masyarakat yang memakai internet provider seluler. Salah satu faktor yang perlu dikaji yaitu kualitas pelayanan terhadap kepuasan pelanggan. Tujuan penelitian ini untuk membuktikan adanya kualitas layanan berpengaruh terhadap kepuasan pelanggan pada saat pelanggan (mahasiswa) melaksanakan pembelajaran daring. Penelitian ini menggunakan gabungan teori Service Performance (SERVPERF) dan Expevtation Confirmation Theory (ECT) dengan memakai variabel network quality dan competitive advantage untuk SERVPERF dan satisfaction untuk ECT. Metode yang dipakai pada penelitian ini adalah dengan metode kuantitatif, pengambilan data menggunakan teknik purposive sampling menggunakan sampel berdasarkan tabel Ishac dan Michael dengan melakukan penyebaran kuisioner. Proses analisa data menggunakan aplikasi pendukung SmartPLS dan memiliki jumlah responden sebanyak 348 yang terdiri dari berbagai mahasiswa Universitas di Jawa Timur. Hasil dari penelitian ini menunjukan bahwasannya adanya pengaruh antar variabel dari kualitas layanan yaitu network quality dan copetitiive advantage bernilai positif dengan bukti nilai path 0 sebesar 0,153 untuk variabel network quality dan untuk 0,136 pada variabel competitive advantage dan signifikan dibuktikan dengan nilai T statistic 1.67 dan P Values 0,05
“World Literature” between Transcultural Poetics and Colonial Politics: Yang Chichang, Le Moulin, and Surrealism in Taiwan
Authors: CHEN Fangdai 
Published: January 2023

This article investigates the artistic and political significance of the Le Moulin poetry society (Fengche shishe) to both Taiwan literature and world literature. Founded in 1933 in occupied Taiwan, the group consisted of Taiwanese and Japanese poets united by their aim to adopt the surrealist poetics that circulated from France via Japan. Although revisionist efforts have been made in the past two decades to integrate Le Moulin into Taiwan’s literary history, existing scholarship has largely adopted postcolonial and Sinophone frameworks. Huang Yali’s 2016 documentary, however, propounds the possibility of considering Le Moulin as world literature in Kuei-fen Chiu’s dual definition — participating in the formation of a world community of cross-cultural exchanges and opening up new literary worlds through aesthetic experimentation. This article expands Chiu’s model by contending that the Le Moulin poets’ subjugation by colonial politics and their controversial articulations of so-called “colonized mentality” were integral parts of their participation in and identification with world literature. This investigation of their political awareness and efforts to participate in the surrealist movement reveals how they unceasingly crusaded for the survival of a “world of literature” against external forces that sought to eliminate literature’s expressive potential in response to its time. Although their unilateral transculturation of French surrealism does not fit with David Damrosch’s model of translation and global circulation, Le Moulin’s contribution to the continuation and maintenance of surrealism and avant-garde poetry prompts us to reconsider and recognize the merits of works of world literature that have so far been marginalized.
VALUASI LINGKUNGAN DALAM PENENTUAN POTENSI EKONOMI OBJEK MIKROWISATA DESA TANGGERAN, TONJONG, BREBES, JAWA TENGAH
Authors: Safitra Dhian Adhetiya , Suheri Asep 
Published: January 2023

Pandemi menyebabkan perlunya lapangan pekerjaan baru. Sebagian tenaga kerja asal daerah perdesaan banyak mengalami pemutusan hubungan kerja karena berkurangnya lapangan pekerjaan yang signifikan. Salah satu lapangan pekerjaan yang dapat menjadi opsi menampung tenaga kerja tersbut adalah sektor wisata. Dengan konsep community based toirsm, tenaga kerja lokal dapat terserap bagi daerah yang memiliki potensi wisata alam. Tantangan yang dihadapi calon objek wisata adalah berapa besar potensi ekonomi objek tersebut dan berapa tarif yang akan ditetapkan. Penelitian ini bertujuan mencari potensi ekonomi dari objek penelitian yang dapat digunakan pengelola objek mikrowisata dalam penentuan tarif atau rentang harga yang digunakan dalam penjualan kuliner atau barang/jasa lain. Penelitian ini menggunakan valuasi lingkunagn dengan Travel Cost Method menghitung beberapa potensi ekonomi objek untuk dijadikan dasar investor berinvestasi pada objek penelitian. Selain itu, pengelola juga dapat menggunakan rata-rata willingnes to pay (WTP) sebagai dasar penentuan tarif masuk, parkir, dan harga kuliner yang ditawarkan. Memperhatikan preferensi pengunjung adalah objek wisata yang berkesan gratis, maka nilai WTP untuk tarif masuk adalah Rp0. Penelitian ini menghasilkan kesimpulan bahwa tanpa pengelolaan objek mikrowisata memiliki nilai Rp63.129.290,00 hingga Rp71.835.382,00 sedangkan jika dikelola potensinya meningkat menjadi Rp5.752.023.104,00. Harga kuliner yang direkomendasikan adalah tidak lebih dari Rp12.084,00 sedangkan tarif parkir dapat dipungut sebesar Rp1.000,00.
Joint modeling of rainfall and temperature in Bahir Dar, Ethiopia: Application of copula
Authors: Fenta Haile Mekonnen , Workie Demeke Lakew , Zikie Dereje Tesfaye 
Published: January 2023

ObjectiveClimate change has effects on the economy development of any country. This paper aimed to fit the best marginal and joint distribution models of rainfall with minimum and maximum temperatures.MethodsThe average values of minimum and maximum monthly temperature, and rainfall were used in this study. For the marginal model, five probability distributions and five families of copula models were employed to show the interdependence between the maximum and minimum average annual temperature with rainfall. The Kendall's tau (τ) correlation coefficient was used to find out the correlations between rainfall with minimum and maximum temperature. Both the Akaki Information Criteria (AIC) and Bayesian information criteria (BIC) were used to select the best marginal and copula.ResultsThe result revealed that there is a significant negative relationship between the maximum temperature and rainfall. The maximum average rainfall was obtained from June to August and the maximum temperature is almost consistent in all months. Based on AIC/BIC, the Weibull distribution for rainfall, the Beta for minimum, and the Gaussian for maximum temperature were identified as the best marginal distributions. The Clayton copula distribution was identified as the best copula for rainfall and minimum temperature (with parameter of θ =1. 21, tau correlation = −0.41, p &lt; 0.001), and Frank copula was identified for rainfall and maximum temperature (with unique Frank parameter of θ = −3.94, correlation = −0.38, p &lt; 0.001).ConclusionThe result showed that there is a significant positive relationship between the average annual minimum temperature and rainfall; whereas a negative relationship occurred between the maximum temperature and rainfall. The Clayton and Frank copula were found to be the most appropriate to the model of a bivariate distribution of mean annual rainfall with minimum/maximum temperature respectively.
In vitro anti-Leishmania activity of triclabendazole and its synergic effect with amphotericin B
Authors: Borges Beatriz Santana , Bueno Gislayne de Paula , Tomiotto-Pellissier Fernanda , Figueiredo Fabiano Borges , Soares Medeiros Lia Carolina 
Published: January 2023

IntroductionLeishmaniasis is a neglected tropical disease, with approximately 1 million new cases and 30,000 deaths reported every year worldwide. Given the lack of adequate medication for treating leishmaniasis, drug repositioning is essential to save time and money when searching for new therapeutic approaches. This is particularly important given leishmaniasis’s status as a neglected disease. Available treatments are still far from being fully effective for treating the different clinical forms of the disease. They are also administered parenterally, making it challenging to ensure complete treatment, and they are extremely toxic, in some cases, causing death. Triclabendazole (TCBZ) is a benzimidazole used to treat fasciolosis in adults and children. It presents a lower toxicity profile than amphotericin B (AmpB) and is administered orally, making it an attractive candidate for treating other parasitoses. The mechanism of action for TCBZ is not yet well understood, although microtubules or polyamines could potentially act as a pharmacological target. TCBZ has already shown antiproliferative activity against T. cruzi, T. brucei, and L. infantum. However, further investigations are still necessary to elucidate the mechanisms of action of TCBZ.MethodsCytotoxicity assay was performed by MTT assay. Cell inhibition (CI) values were obtained according to the equation CI = (O.D treatment x 100/O.D. negative control). For Infection evaluation, fixated cells were stained with Hoechst and read at Operetta High Content Imaging System (Perkin Elmer). For growth curves, cell culture absorbance was measured daily at 600 nm. For the synergism effect, Fractional Inhibitory Concentrations (FICs) were calculated for the IC50 of the drugs alone or combined. Mitochondrial membrane potential (DYm), cell cycle, and cell death analysis were evaluated by flow cytometry. Reactive oxygen species (ROS) and lipid quantification were also determined by fluorimetry. Treated parasites morphology and ultrastructure were analyzed by electron microscopy.ResultsThe selectivity index (SI = CC50/IC50) of TCBZ was comparable with AmpB in promastigotes and amastigotes of Leishmania amazonensis. Evaluation of the cell cycle showed an increase of up to 13% of cells concentrated in S and G2, and morphological analysis with scanning electron microscopy showed a high frequency of dividing cells. The ultrastructural analysis demonstrated large cytoplasmic lipid accumulation, which could suggest alterations in lipid metabolism. Combined administration of TCBZ and AmpB demonstrated a synergistic effect in vitro against intracellular amastigote forms with cSFICs of 0.25.ConclusionsConsidering that TCBZ has the advantage of being inexpensive and administrated orally, our results suggest that TCBZ, combined with AmpB, is a promising candidate for treating leishmaniasis with reduced toxicity.
Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
Authors: Chen Danchun , Tang Benyu , Li Ying , Zheng Kelu , Li Xiaojing , Chen Wenxiong , Gao Fei , Gao Yuanyuan , Shi Kaili 
Published: January 2023

IntroductionBacterial meningitis (BM) is an infectious disease with high morbidity and mortality rates in children. Although vaccination has improved prevention of BM, this severe disease continues to cause considerable harm to children across the globe. Several risk factors have been identified for BM, including immune status, age, and sex. However, additional patient and disease information is required in order to better understand the local characteristics, epidemiology and risk factors of BM.MethodsHere, we collected information from 252 children with BM in the Guangzhou Women and Children Medical Centre medical record database infected with Streptococcus agalactiae, Streptococcus pneumoniae, or Escherichia coli between May 2015 and May 2022.ResultsThe three pathogen infected BM cased showed distinct trends during the period, and distribution of three BM pathogens across age groups varied significantly. We reviewed the antimicrobial resistance patterns for each of the pathogens which may direct drug use in BM. Finally, we found blood WBC was a protective factor, while glucose levels in the CFS was risk factor, for the length of hospitalization.DiscussionCollectively, this study provides multi-parameter characteristics of BM, and potentially guide the drug use.
Associations of eicosapentaenoic acid and docosahexaenoic acid intakes with cardiovascular and all-cause mortality in patients with diabetes: Result from National Health and Nutrition Examination Survey 1999–2008
Authors: Huang Nian , Wang Fang , Li Shiyang , Zhai Xiaobing , Ma Wenzhi , Liu Keyang , Sheerah Haytham A. , Cao Jinhong , Eshak Ehab S. 
Published: January 2023

IntroductionThe evidence on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake status and long-term mortality among people with diabetes is scarce. This study aimed to investigate the relationship between EPA and DHA intakes with all-cause and cause-specific mortality in adults with diabetes.MethodsThis study included 2,991 adults with diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999–2008. Death outcomes were ascertained by linkage to the database records through 31 December 2015. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from all causes, cardiovascular disease (CVD), and coronary heart disease (CHD) in patients with diabetes.ResultsAmong 2,991 patients with diabetes, the mean age was 61.9 years (55.2% males). During the mean follow-up duration of 9.4 years, a total of 1,091 deaths were documented, of which 273 were due to CVD, including 227 CHD deaths. EPA and DHA intakes were associated with lower mortality risks, especially that of CVD. After adjusting for demographic, major lifestyle factors, overall dietary intake patterns, and history of hypertension and dyslipidemia, the multivariable HRs (95% CIs) of mortality risk comparing Q4 to Q1 of EPA intake were 0.55 (0.33–0.92; P-trend = 0.019) for CHD, 0.55 (0.36–0.83; P-trend = 0.005) for CVD, and 0.91 (0.70–1.18; P-trend = 0.264) for all-cause. The respective HRs (95% CIs) comparing Q4 to Q1 of DHA were 0.60 (0.37–0.98; P-trend = 0.051) for CHD, 0.58 (0.38–0.89; P-trend = 0.014) for CVD, and 0.92 (0.72–1.18; P-trend = 0.481) for all-cause. In subgroup analysis, we found that the association trends of EPA and DHA intakes with death risk remained robust among patients with diabetes, especially among those who are old, female, those with higher BMI, and dyslipidemia patients with CVD and CHD.DiscussionIn the USA, higher EPA and DHA intakes were associated with a lower risk of CHD and CVD mortality in patients with diabetes. Our study supports the benefits of adequate EPA and DHA intakes in promoting the health of patients with diabetes.
Plasma protein profiling analysis in patients with atrial fibrillation before and after three different ablation techniques
Authors: Lin Menglu , Bao Yangyang , Du Zunhui , Zhou Yanting , Zhang Ning , Lin Changjian , Xie Yinyin , Zhang Ruihong , Li Qiheng , Quan Jinwei , Zhu Tingfang , Xie Yuan , Xu Cathy , Xie Yun , Wei Yue , Luo Qingzhi , Pan Wenqi , Wang Lingjie , Ling Tianyou , Jin Qi , Wu Liqun , Yin Tong , Xie Yucai 
Published: January 2023

BackgroundThere are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.ObjectivesWe evaluated the changes in plasma proteins in acute phase post-ablation in patients receiving cryoballoon ablation, radiofrequency balloon ablation, or radiofrequency ablation.MethodsBlood samples from eight healthy controls and 24 patients with AF were taken on the day of admission, day 1, and day 2 post-ablation and analyzed by the Olink proximity extension assay. Proteins were identified and performed with enrichment analysis. Protein–protein interaction network and module analysis were conducted using Cytoscape software.ResultsOf 181 proteins, 42 proteins in the cryoballoon group, 46 proteins in the radiofrequency balloon group, and 43 proteins in the radiofrequency group significantly changed after ablation. Most of the proteins altered significantly on the first day after ablation. Altered proteins were mainly involved in cytokine–cytokine receptor interaction. Both balloon-based ablations showed a similar shift toward enhancing cell communication and regulation of signaling while inhibiting neutrophil chemotaxis. However, radiofrequency ablation presented a different trend. Seed proteins, including osteopontin, interleukin-6, interleukin-10, C-C motif ligand 8, and matrix metalloproteinase-1, were identified. More significant proteins associated with hemorrhage and coagulation were selected in balloon-based ablations by machine learning.ConclusionPlasma protein response after three different ablations in patients with AF mainly occurred on the first day. Radiofrequency balloon ablation shared similar alteration in protein profile as cryoballoon ablation compared with radiofrequency ablation, suggesting that lesion size rather than energy source is the determinant in pathophysiological responses to the ablation.
Left ventricular hypertrophy, diastolic dysfunction and right ventricular load predict outcome in moderate aortic stenosis
Authors: Stöbe Stephan , Kandels Joscha , Metze Michael , Tayal Bhupendar , Laufs Ulrich , Hagendorff Andreas 
Published: January 2023

AimsPredictors of progression of moderate aortic valve stenosis (AS) are incompletely understood. The objective of this study was to evaluate the prognostic value of left ventricular hypertrophy (LVH), diastolic dysfunction, and right ventricular (RV) load in moderate AS.Methods and resultsModerate AS was defined by aortic valve area (AVA), peak transvalvular velocity (Vmax) or mean pressure gradient (PGmean). A total of 131 Patients were divided into two groups according to the number of pathophysiological changes (LVH, diastolic dysfunction with increased LV filling pressures and/or RV load): &lt;2 (group 1); ≥2 (group 2). The primary outcome was survival without aortic valve replacement (AVR). After follow-up of 30 months, the reduction of AVA (–0.06 ± 0.16 vs. –0.24 ± 0.19 cm2, P &lt; 0.001), the increase of PGmean (2.89 ± 6.35 vs 6.29 ± 7.13 mmHg, P &lt; 0.001) and the decrease of the global longitudinal strain (0.8 ± 2.56 vs. 1.57 ± 3.42%, P &lt; 0.001) from baseline to follow-up were significantly more pronounced in group 2. Survival without AVR was 82% (group 1) and 56% (group 2) [HR 3.94 (1.74–8.94), P &lt; 0.001]. Survival without AVR or progression of AS was 77% (group 1) and 46% (group 2) [HR 3.80 (1.84–7.86), P &lt; 0.001]. The presence of ≥2 pathophysiological changes predicted outcome whereas age, comorbidities, LDL-cholesterol did not.ConclusionThe presence of ≥2 pathophysiological changes is a strong predictor of outcome in moderate AS and may be useful for risk stratification, particularly for scheduling follow-up time intervals and deciding the timing of AVR.