bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Reproducible is the Synthesis of Zr–Porphyrin Metal–Organic Frameworks? An Interlaboratory Study
Authors: Boström Hanna L. B. , Emmerling Sebastian , Heck Fabian , Koschnick Charlotte , Jones Andrew J. , Cliffe Matthew J. , Al Natour Rawan , Bonneau Mickaële , Guillerm Vincent , Shekhah Osama , Eddaoudi Mohamed , Lopez‐Cabrelles Javier , Furukawa Shuhei , Romero‐Angel María , Martí‐Gastaldo Carlos , Yan Minliang , Morris Amanda J. , Romero‐Muñiz Ignacio , Xiong Ying , Platero‐Prats Ana E. , Roth Jocelyn , Queen Wendy L. , Mertin Kalle S. , Schier Danielle E. , Champness Neil R. , Yeung Hamish H.‐M. , Lotsch Bettina V. 
Published: September 2023

AbstractMetal–organic frameworks (MOFs) are a rapidly growing class of materials that offer great promise in various applications. However, the synthesis remains challenging: for example, a range of crystal structures can often be accessed from the same building blocks, which complicates the phase selectivity. Likewise, the high sensitivity to slight changes in synthesis conditions may cause reproducibility issues. This is crucial, as it hampers the research and commercialization of affected MOFs. Here, it presents the first‐ever interlaboratory study of the synthetic reproducibility of two Zr–porphyrin MOFs, PCN‐222 and PCN‐224, to investigate the scope of this problem. For PCN‐222, only one sample out of ten was phase pure and of the correct symmetry, while for PCN‐224, three are phase pure, although none of these show the spatial linker order characteristic of PCN‐224. Instead, these samples resemble dPCN‐224 (disordered PCN‐224), which has recently been reported. The variability in thermal behavior, defect content, and surface area of the synthesised samples are also studied. The results have important ramifications for field of metal–organic frameworks and their crystallization, by highlighting the synthetic challenges associated with a multi‐variable synthesis space and flat energy landscapes characteristic of MOFs.
Water‐Resistant Subwavelength Perovskite Lasing from Transparent Silica‐Based Nanocavity
Authors: Huang Sihao , Shen Zixi , Liao Yang , Liu Zhengzheng , Hu Zhiping , Li Qian , Zhang Zeyu , Dong Siyu , Luo Jiajun , Du Juan , Tang Jiang , Leng Yuxin 
Published: September 2023

AbstractGreat research efforts are devoted to exploring the miniaturization of chip‐scale coherent light sources possessing excellent lasing performance. Despite the indispensable role in Si photonics, SiO2 is generally considered not contributing to the starting up and operation of integrated lasers. Here, this work demonstrates an extraordinary‐performance subwavelength‐scale perovskite vertical cavity laser with all‐transparent SiO2 cavity, whose cavity is ultra‐simple and composed of only two parallel SiO2 plates. By introducing a ligand‐assisted thermally co‐evaporation strategy, highly luminescent perovskite film with high reproducibility and excellent optical gain is grown directly on SiO2. Benefitting from their high‐refractive‐index contrast, low‐threshold, high‐quality factor, and single‐mode lasing is achieved in subwavelength range of ≈120 nm, and verified by long‐range coherence distance (115.6 µm) and high linear polarization degree (82%). More importantly, the subwavelength perovskite laser device could operate in water for 20 days without any observable degradation, exhibiting ultra‐stable water‐resistant performance. These findings would provide a simple but robust and reliable strategy for the miniaturized on‐chip lasers compatible with Si photonics.
A Data‐Driven Approach to Molten Salt Synthesis of N‐Rich Carbon Adsorbents for Selective CO2 Capture
Authors: Burrow James N. , Eichler John E. , Martinez Wuilian A. , Mullins C. Buddie 
Published: September 2023

AbstractApplying a design of experiments methodology to the molten salt synthesis of nanoporous carbons enables inverse design and optimization of nitrogen (N)‐rich carbon adsorbents with excellent CO2/N2 selectivity and appreciable CO2 capacity for carbon capture via swing adsorption from dilute gas mixtures such as natural gas combined cycle flue gas. This data‐driven study reveals fundamental structure‐function relationships between the synthesis conditions, physicochemical properties, and achievable selective adsorption performance of N‐rich nanoporous carbons derived from molten salt synthesis for CO2 capture. Taking advantage of size‐sieving separation of CO2 (3.30 Å) from N2 (3.64 Å) within the turbostratic nanostructure of these N‐rich carbons, while limiting deleterious N2 adsorption in a weaker adsorption site that harms selectivity, enables a large CO2 capacity (0.73 mmol g−1 at 30.4 Torr and 30 °C) with noteworthy concurrent CO2/N2 selectivity as predicted by the ideal adsorbed solution theory (SIAST = 246) with an adsorbed phase purity of 91% from a simulated gas stream containing only 4% CO2. Optimized N‐rich porous carbons, with good physicochemical stability, low cost, and moderate regeneration energy, can achieve performance for selective CO2 adsorption that competes with other classes of advanced porous materials such as chemisorbing zeolites and functionalized metal‐organic frameworks.
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post‐Myocardial Infarction via Human Antigen R
Authors: Guo Chenghu , Ji Wei , Yang Wei , Deng Qiming , Zheng Tengfei , Wang Zunzhe , Sui Wenhai , Zhai Chungang , Yu Fangpu , Xi Bo , Yu Xiao , Xu Feng , Zhang Qunye , Zhang Wencheng , Kong Jing , Zhang Meng , Zhang Cheng 
Published: September 2023

AbstractMyocardial infarction (MI) remains the leading cause of death worldwide. Cardiac fibroblasts (CFs) are abundant in the heart and are responsible for cardiac repair post‐MI. NF‐κB‐repressing factor (NKRF) plays a significant role in the transcriptional inhibition of various specific genes. However, the NKRF action mechanism in CFs remains unclear in cardiac repair post‐MI. This study investigates the NKRF mechanism in cardiac remodeling and dysfunction post‐MI by establishing a CF‐specific NKRF‐knockout (NKRF‐CKO) mouse model. NKRF expression is downregulated in CFs in response to pathological cardiac remodeling in vivo and TNF‐α in vitro. NKRF‐CKO mice demonstrate worse cardiac function and survival and increased infarct size, heart weight, and MMP2 and MMP9 expression post‐MI compared with littermates. NKRF inhibits CF migration and invasion in vitro by downregulating MMP2 and MMP9 expression. Mechanistically, NKRF inhibits human antigen R (HuR) transcription by binding to the classical negative regulatory element within the HuR promoter via an NF‐κB‐dependent mechanism. This decreases HuR‐targeted Mmp2 and Mmp9 mRNA stability. This study suggests that NKRF is a therapeutic target for pathological cardiac remodeling.
Recent Progress on the Catalysts and Device Designs for (Photo)Electrochemical On‐Site H2O2 Production
Authors: Wang Qi , Ren Liping , Zhang Jie , Chen Xin , Chen Chunying , Zhang Fei , Wang Shuai , Chen Jie , Wei Jinjia 
Published: September 2023

AbstractLow‐cost and on‐site H2O2 production is desirable for industrial and civilian usage. (Photo)electrochemical H2O2 production is proposed to be a safer, greener, and cheaper strategy for on‐site H2O2 production as compared to the conventional anthraquinone process and the direct thermal synthesis. However, the efficiency, selectivity, and durability of the (photo)electrochemical H2O2 production devices are still not satisfactory. Therefore, there is an urgent need to revisit the (photo)electrocatalyst and device designs for (photo)electrochemical on‐site H2O2 production, thus to rationalize the research thoughts and provide valuable guidance. This review comprehensively summarizes and discusses the mechanism of two‐electron oxygen reduction reaction (2e− ORR) and two‐electron water oxidation reaction (2e− WOR) for H2O2 production, and the current research status on the (photo)electrocatalysts and (photo)electrochemical devices. In particular, the pros and cons of the four types of (photo)electrochemical device designs, which are Type I (2e− ORR + oxygen evolution reaction), Type II (2e− ORR + hydrogen oxidation reaction), Type III (2e− WOR + hydrogen evolution reaction) and Type IV (2e− WOR + 2e− ORR), are discussed in detail. Finally, a practical perspective on the future research directions for the on‐site (photo)electrochemical H2O2 production based on the technical challenges of this technique is provided.
Magnetoresistance in Organic Spin Valves Based on Acid‐Exfoliated 2D Covalent Organic Frameworks Thin Films
Authors: Liu Xitong , Li Hao , Zhang Weifeng , Yang Zhen , Li Dong , Liu Mengya , Jin Kuijuan , Wang Liping , Yu Gui 
Published: September 2023

AbstractCovalent organic frameworks (COFs), as a burgeoning class of crystalline porous materials, have made significant progress in their application to optoelectronic devices such as field‐effect transistors, memristors, and photodetectors. However, the insoluble features of microcrystalline two‐dimensional (2D) COF powders limit development of their thin film devices. Additionally, the exploration of spin transport properties in this category of π‐conjugated skeleton materials remains vacant thus far. Herein, an imine‐linked 2D Py‐Np COF nanocrystalline powder was synthesized by Schiff base condensation of 4,4′,4′′,4′′′‐(pyrene‐1,3,6,8‐tetrayl)tetraaniline and naphthalene‐2,6‐dicarbaldehyde. Then, we prepared a large‐scale free‐standing Py‐Np COF film via a top‐down strategy of chemically assisted acid exfoliation. Moreover, high‐quality COF films acted as active layers were transferred onto ferromagnetic La0.67Sr0.33MnO3(LSMO) electrodes for the first attempt to fabricate organic spin valves (OSVs) based on 2D COF materials. This COF‐based OSV device with a configuration of LSMO/Py‐Np COF/Co/Au demonstrated a remarkable magnetoresistance (MR) value up to −26.5 % at 30 K. Meanwhile, the MR behavior of the COF‐based OSVs exhibited a highly temperature dependence and operational stability. This work highlights the enormous application prospects of 2D COFs in organic spintronics and provides a promising approach for developing electronic and spintronic devices based on acid‐exfoliated COF thin films.
Customizing amino acid metabolism of Pichia pastoris for recombinant protein production
Authors: Rußmayer Hannes , Buchetics Markus , Mattanovich Matthias , Neubauer Stefan , Steiger Matthias , Graf Alexandra B. , Koellensperger Gunda , Hann Stephan , Sauer Michael , Gasser Brigitte , Mattanovich Diethard 
Published: September 2023

AbstractAmino acids are the building blocks of proteins. In this respect, a reciprocal effect of recombinant protein production on amino acid biosynthesis as well as the impact of the availability of free amino acids on protein production can be anticipated. In this study, the impact of engineering the amino acid metabolism on the production of recombinant proteins was investigated in the yeast Pichia pastoris (syn Komagataella phaffii). Based on comprehensive systems‐level analyses of the metabolomes and transcriptomes of different P. pastoris strains secreting antibody fragments, cell engineering targets were selected. Our working hypothesis that increasing intracellular amino acid levels could help unburden cellular metabolism and improve recombinant protein production was examined by constitutive overexpression of genes related to amino acid metabolism. In addition to 12 genes involved in specific amino acid biosynthetic pathways, the transcription factor GCN4 responsible for regulation of amino acid biosynthetic genes was overexpressed. The production of the used model protein, a secreted carboxylesterase (CES) from Sphingopyxis macrogoltabida, was increased by overexpression of pathway genes for alanine and for aromatic amino acids, and most pronounced, when overexpressing the regulator GCN4. The analysis of intracellular amino acid levels of selected clones indicated a direct linkage of improved recombinant protein production to the increased availability of intracellular amino acids. Finally, fed batch cultures showed that overexpression of GCN4 increased CES titers 2.6‐fold, while the positive effect of other amino acid synthesis genes could not be transferred from screening to bioreactor cultures.
Macrophage cell morphology‐imprinted substrates can modulate mesenchymal stem cell behaviors and macrophage M1/M2 polarization for wound healing applications
Authors: Majidi Mohammad , Pakzad Saeedreza , Salimi Maryam , Azadbakht Abdolnaser , Hajighasemlou Saieh , Amoupour Moein , Nokhbedehghan Zeinab , Bonakdar Shahin , Sineh Sepehr Koushan , Pal Singh Chauhan Narendra , Gholipourmalekabadi Mazaher 
Published: September 2023

AbstractMesenchymal stem cells and macrophages (MQ) are two very important cells involved in the normal wound healing process. It is well understood that topological cues and mechanical factors can lead to different responses in stem cells and MQ by influencing their shape, cytoskeleton proliferation, migration, and differentiation, which play an essential role in the success or failure of biomaterial implantation and more importantly wound healing. On the other hand, the polarization of MQ from proinflammatory (M1) to prohealing (M2) phenotypes has a critical role in the acceleration of wound healing. In this study, the morphology of different MQ subtypes (M0, M1, and M2) was imprinted on a silicon surface (polydimethylsiloxane [PDMS]) to prepare a nano‐topography cell‐imprinted substrate with the ability to induce anti‐inflammatory effects on the mouse adipose‐derived stem cells (ADSCs) and RAW264.7 monocyte cell line (MO). The gene expression profiles and flow cytometry of MQ revealed that the cell shape microstructure promoted the MQ phenotypes according to the specific shape of each pattern. The ELISA results were in agreement with the gene expression profiles. The ADSCs on the patterned PDMS exhibited remarkably different shapes from no‐patterned PDMS. The MOs grown on M2 morphological patterns showed a significant increase in expression and section of anti‐inflammatory cytokine compared with M0 and M1 patterns. The ADSCs homing in niches heavily deformed the cytoskeletal, which is probably why the gene expression and phenotype unexpectedly changed. In conclusion, wound dressings with M2 cell morphology‐induced surfaces are suggested as excellent anti‐inflammatory and antiscarring dressings.
Contrast media volume reduction with the DyeVertTM system to prevent acute kidney injury in stable patients undergoing coronary procedures
Authors: Paolucci Luca , De Micco Francesca , Bezzeccheri Andrea , Scarpelli Mario , Esposito Giovanni , Airoldi Flavio , Focaccio Amelia , Briguori Carlo 
Published: September 2023

AbstractBackgroundContrast associated acute kidney injury (CA‐AKI) can lead to an increased risk of adverse events. Contrast media (CM) volume reduction has been advocated as a pivotal strategy to prevent CA‐AKI in stable patients undergoing percutaneous coronary procedures.AimsTo compare the effectiveness of CM volume reduction with the DyeVertTM system versus conventional strategy in reducing the risk of CA‐AKI.MethodsWe prospectively collected data from 136 patients with stable coronary artery disease at high risk of CA‐AKI treated with left ventricular end diastolic pressure (LVEDP)‐ guided hydration and undergoing interventions with the use of the DyeVertTM (Osprey Medical Inc.) system. Patients previously enrolled in the LVEDP‐guided hydration arm of the “Renal Insufficiency Following Contrast MEDIA Administration triaL III” (REMEDIAL III) were considered as controls. Propensity score was used to perform 1:1 matching to adjust for major confounders. The primary outcome was the occurrence of CA‐AKI, as defined by an absolute increase of creatinine values ≥0.3 mg/dL at 48 h.ResultsPatients in the DyeVert group were treated with a significant lower CM volume (median: 47.5 vs. 84.0 mL, p < 0.001). The trend in creatinine increase was lower (p = 0.004) and the Δ of creatinine (0−48 h) showed a higher drop (−0.18 vs. −0.10 mg/dL, p = 0.036) in the DyeVert group. The risk of CA‐AKI was significantly lower in DyeVert group compared to control group (5.1% vs. 16.8%; odds ratio 0.27, 95% confidence interval [0.12−0.61]).ConclusionsCM volume reduction with the DyeVertTM system seems to be superior to conventional strategies in reducing the occurrence of CA‐AKI.
Mid‐term outcomes and hemodynamic performance of transcatheter aortic valve implantation in bicuspid aortic valve stenosis: Insights from the bicuSpid TAvi duraBILITY (STABILITY) registry
Authors: Fiorina Claudia , Massussi Mauro , Ancona Marco , Montorfano Matteo , Petronio Anna Sonia , Tarantini Giuseppe , Castriota Fausto , Chizzola Giuliano , Costa Giuliano , Tamburino Corrado , Adamo Marianna 
Published: September 2023

AbstractBackgroundLimited data are available on transcatheter heart valves (THVs) durability in bicuspid aortic valve (BAV) stenosis.AimsTo evaluate evaluating 4‐year clinical and echocardiographic outcomes of patients with BAV undergoing transcatheter aortic valve implantation (TAVI).MethodsThe bicuSpid TAvi duraBILITY (STABILITY) registry is an Italian multicentre registry including all consecutive patients with BAV and severe aortic stenosis (AS), treated by means of TAVI between January 2011 and December 2017. Outcomes of interest were all‐cause death at 4‐year, over time changes in echocardiographic measurements, and THV durability according to the valve aortic research consortium (VARC)‐3 update definitions.ResultsStudy population included 109 patients (50% females; mean age 78 ± 7.5 years) with a mean Society of Thoracic Surgeons Predicted Risk of Mortality score of 5.1 ± 4.3%. Median follow‐up (FU) duration was 4.1 years [interquartile range: 2.8–5.1]. The overall cumulative incidence of all‐cause death by Kaplan–Meier estimates at 4 years was 32%. Compared to baseline, a significant decrease in transprosthetic mean gradient was obtained after TAVI (54 ± 16 vs. 10 ± 5 mmHg; p < 0.001), whereas a significant increase was observed at 4‐year (13 ± 6.4 mmHg, p = 0.03). Cumulative incidence of hemodynamic valve dysfunction (HVD) was 4%. Six patients met HVD criteria: three moderate and three severe HVD. All three cases of severe HVD were clinically relevant (bioprosthetic valve failure [BVF]) with two patients receiving a reintervention (TAVI in TAVI), and one patient experiencing a valve‐related death due to endocarditis.ConclusionsThe STABILITY registry suggests that in patients with severe AS and BAV undergoing TAVI, postprocedural clinical benefits might last, over time, up to 4‐year FU. The low rates of severe HVD and BVF may support the hypothesis of good THV durability also in BAV recipient.
Prosthesis‐patient mismatch after transcatheter implantation of contemporary balloon‐expandable and self‐expandable valves in small aortic annuli
Authors: Leone Pier Pasquale , Regazzoli Damiano , Pagnesi Matteo , Costa Giuliano , Teles Rui , Adamo Marianna , Taramasso Maurizio , De Marco Federico , Mangieri Antonio , Kargoli Faraj , Ohno Yohei , Saia Francesco , Ielasi Alfonso , Ribichini Flavio , Maffeo Diego , Kim Won‐Keun , Maisano Francesco , Van Mieghem Nicolas M. , Colombo Antonio , Reimers Bernhard , Latib Azeem ,   the TAVI‐SMALL Investigators
Published: September 2023

AbstractBackgroundEvidence of clinical impact of PPM after TAVI is conflicting and might vary according to the type of valve implanted.AimsTo assess the clinical impact of prosthesis‐patient mismatch (PPM) after transcatheter aortic valve implantation (TAVI) with balloon‐expandable (BEV) and self‐expandable valves (SEV) in patients with small annuli.MethodsTAVI‐SMALL 2 enrolled 628 patients in an international retrospective registry, which included patients with severe aortic stenosis and small annuli (annular perimeter <72 mm or area <400 mm2) treated with transfemoral TAVI at 16 high‐volume centers between 2011 and 2020. Analyses were performed comparing patients with less than moderate (n = 452), moderate (n = 138), and severe PPM (n = 38). Primary endpoint was incidence of all‐cause mortality. Predictors of all‐cause mortality and PPM were investigated.ResultsAt a median follow‐up of 380 days (interquartile range: 210–709 days), patients with severe PPM, but not moderate PPM, had an increased risk of all‐cause mortality when compared with less than moderate PPM (log‐rank p = 0.046). Severe PPM predicted all‐cause mortality in patients with BEV (hazard ratio [HR]: 5.20, 95% confidence interval [CI]: 1.27–21.2) and intra‐annular valves (IAVs, HR: 4.23, 95% CI: 1.28–14.02), and it did so with borderline significance in the overall population (HR: 2.89, 95% CI: 0.95–8.79). Supra‐annular valve (SAV) implantation was the only predictor of severe PPM (odds ratio: 0.33, 95% CI: 0.13–0.83).ConclusionsPatients with small aortic annuli and severe PPM after TAVI have an increased risk of all‐cause mortality at early term follow‐up, especially after IAV or BEV implantation. TAVI with SAV protected from severe PPM.
Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection
Authors: Raherison Rija Eric , Raharinavalona Sitraka Angelo , Razanamparany Thierry , Randrianotahiana Theo Njakasoa , Randrianomanana Tsikinirina Valisoa , Andrianiaina Miora Maeva Arielle , Rakotomalala Andrianirina Dave Patrick , Andrianasolo Radonirina Lazasoa 
Published: September 2023

Key Clinical MessageThe main type of urinary tract infection in hospitalized diabetics in Antananarivo is acute pyelonephritis;Escherichia coliis the most isolated uropathogen; imipenem, amikacin, fosfomycin and ceftriaxone are the major antibiotics for whichEscherichia coliretain good sensitivity; Type 2 diabetes is predictive factor for infection by multidrug resistant bacteria.AbstractThis study aimed to describe the epidemiological‐clinical profiles of diabetics hospitalized for bacterial urinary tract infections in the Endocrinology Department of Befelatanana Hospital, to identify the main bacteria responsible, their antibiotic sensitivity profile and the factors associated with multidrug‐resistant bacterial infection. A cross‐sectional study was conducted between March 2017 and March 2020 involving all diabetics hospitalized for documented community‐acquired bacterial urinary tract infection during this period. The hospital prevalence of urinary tract infections was 4.64%. The mean age of the patients was 59.06 ± 14.26 years and the sex ratio was 0.15. The main sign was fever (55.76%). The main clinical form was uncomplicated acute pyelonephritis (38.46%). Fifty‐seven bacterial uropathogens were isolated. The most frequent wasEscherichia coli(77.19%).Escherichia coliwas sensitive to ertapenem and nitrofurantoin in 100% of cases, to Amikacin in 97.5% of cases, to Fosfomycin in 94.4% of cases and to Ceftriaxone in 80.65% of cases. Thirteen patients were infected with multidrug‐resistant bacteria, all of them are extended‐spectrum beta‐lactamase‐producing Enterobacteriaceae. Only the type of diabetes was associated with multidrug‐resistant bacteria infection. The epidemiological‐clinical and biological characteristics of urinary tract infections in our diabetics are similar to those reported in the literature. Compliance with the rules of proper antibiotic use is imperative to limit the emergence and spread of multidrug‐resistant bacteria.