bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstacles to collective action during a crisis: A meta‐organizational perspective
Authors: Hartwell Christopher A. , Lawton Thomas C. , Tingbani Ishmael 
Published: July 2023

AbstractMeta‐organizations form to advance collective action. But collective action can be more difficult to coordinate for meta‐organizations comprising governmental agencies or sovereign states, with system‐level objectives often conflicting. These challenges can be more binding during a crisis, where the responses called for are outside of the original reason for the meta‐organization's existence. We advance a framework for conceptualizing meta‐organizations that focuses on both internal attributes and external perceptions and suggests how each may help or hinder meta‐organization influence during a crisis. Using as a case study the response of the European Union (EU) to COVID‐19 and, specifically, to air travel restrictions at the outbreak of the pandemic, we show how meta‐organizations can have difficulties in responding expeditiously to crises, particularly when encountering contradictory system‐level goals. We argue that meta‐organizations must plan for crises during less turbulent times, developing the processes that contribute to the gradual creation of new system‐level goals.
Effect of limonene associated with bioactive glass‐ceramic on dentin/adhesive interface
Authors: Garcia Pinto Arthur Henrique , Geng‐Vivanco Rocio , Pires‐de‐Souza Fernanda de Carvalho Panzeri 
Published: July 2023

AbstractThis study evaluated the effect of pretreatment with limonene and/or biosilicate on the bond strength of a universal adhesive system in self‐etch mode to dentin. Occlusal cavities were prepared in 80 human molars and the teeth were randomly allocated to one of four groups (n = 20), according to the pretreatment regimens applied before the adhesive. The pretreatments were (i) Control, no pretreatment, (ii) LIM, 0.5% limonene; (iii) Bio, 10% biosilicate; and (iv) LIMBio, LIM + Bio. After adhesive application and restoration, the specimens were sectioned into sticks, separated, and stored in distilled water at 37°C for 24 h or 6 months. Microtensile bond strength test was carried out and measurements were compared across pretreatment groups and storage times. Fracture patterns and adhesive interfaces were observed. Loss of dry mass was calculated (n = 10). There was no statistically significant difference in the bond strength between the groups and the most prevalent fracture pattern was the non‐adhesive. LIM and LIMBio resulted in more open dentinal tubules. LIM and Bio, whether separate or combined, showed particles of those substances, which decreased in size and number after 6 months. All groups lost mass weight after treatment, with no statistically significant differences between them. Limonene and biosilicate pretreatment did not affect the bond strength to dentin of the universal adhesive system, but resulted in more non‐adhesive fractures, even after 6 months.
Tyrosine kinase alterations in colorectal cancer with emphasis on the distinct clinicopathological characteristics
Authors: Okano Soh , Yamashiro Yuya , Onagi Hiroko , Sasa Keita , Hayashi Takuo , Takahashi Makoto , Sugimoto Kiichi , Sakamoto Kazuhiro , Yao Takashi , Saito Tsuyoshi 
Published: July 2023

AimsTyrosine kinase (TK) alterations, such as anaplastic lymphoma kinase (ALK) fusion, neurotrophic tyrosine receptor kinase (NTRK) fusion, c‐ros oncogene 1 (ROS1) fusion and mesenchymal–epithelial transition factor (MET) exon 14 skipping, have been reported in colorectal cancers (CRC). We have previously reported CRCs with NTRK fusion among our cohort. However, their clinicopathological features have not been fully elucidated.Methods and resultsTissue microarray (TMA)‐based immunohistochemistry (IHC) was performed on 951 CRC lesions from 944 patients. IHC was evaluated as positive or negative for ALK and ROS1 and 0 to 3+ for c‐MET. For ALK and ROS1 IHC‐positive cases, RNA‐based imbalanced gene expression assays, Archer FusionPlex assays and reverse transcription–polymerase chain reaction (RT‐PCR) followed by Sanger sequencing were performed. For c‐MET IHC 3+ cases, RT‐PCR followed by Sanger sequencing were performed. ALK IHC was positive in three cases (0.2%) and all showed imbalanced ALK gene expression. The following ALK fusions were confirmed: EML4 (exon 21)::ALK (exon 20), EML4 (exon 6)::ALK (exon 19) and HMBOX1 (exon 6)::ALK (exon 20). Two showed microsatellite instability‐high/mismatch repair (MMR)‐deficient, and all were located in the right colon. ROS1 IHC was positive in one case; however, imbalanced expression and ROS1 fusion was negative. Forty‐two cases (4.4%) showed c‐MET IHC3+. MET exon 14 skipping was confirmed in nine cases. All cases were microsatellite stable/MMR‐proficient, and eight were located in the left colon and rectum.ConclusionsCRCs with these TK alterations had distinct clinicopathological features. Together with our previous study, 15 cases (1.6%) harboured targetable TK alterations (three NTRK fusion, three ALK fusion, nine MET exon 14 skipping).
FEN1 inhibitor SC13 promotes CAR‐T cells infiltration into solid tumours through cGAS–STING signalling pathway
Authors: Dong Yunfei , Wang Yuanyuan , Yin Xuechen , Zhu Hongqiao , Liu Lingjie , Zhang Miaomiao , Chen Jiannan , Wang Aying , Huang Tinghui , Hu Jianhua , Liang Junqing , Guo Zhigang , He Lingfeng 
Published: July 2023

AbstractIt is well known that chimeric antigen receptor T‐cell immunotherapy (CAR‐T‐cell immunotherapy) has excellent therapeutic effect in haematological tumours, but it still faces great challenges in solid tumours, including inefficient T‐cell tumour infiltration and poor functional persistence. Flap structure‐specific endonuclease 1 (FEN1), highly expressed in a variety of cancer cells, plays an important role in both DNA replication and repair. Previous studies have reported that FEN1 inhibition is an effective strategy for cancer treatment. Therefore, we hypothesized whether FEN1 inhibitors combined with CAR‐T‐cell immunotherapy would have a stronger killing effect on solid tumours. The results showed that low dose of FEN1 inhibitors SC13 could induce an increase of double‐stranded broken DNA (dsDNA) in the cytoplasm. Cytosolic dsDNA can activate the cyclic GMP–AMP synthase–stimulator of interferon gene signalling pathway and increase the secretion of chemokines. In vivo, under the action of FEN1 inhibitor SC13, more chemokines were produced at solid tumour sites, which promoted the infiltration of CAR‐T cells and improved anti‐tumour immunity. These findings suggest that FEN1 inhibitors could enable CAR‐T cells to overcome poor T‐cell infiltration and improve the treatment of solid tumours.
A mixed‐method systematic literature review of health literacy interventions for people with disabilities
Authors: Nam Hye Jin , Lee Sujin , Park Han Nah , Kim Bohye , Yoon Ju Young 
Published: July 2023

AbstractAimsTo identify the components and characteristics of health literacy interventions for people with disabilities and to explore the outcomes in terms of health literacy competencies.DesignA mixed‐method systematic literature review.Review MethodsThe search results were reported based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis. The quality appraisal was guided by the Mixed Methods Appraisal Tool. The contents of each intervention were mapped to the health literacy intervention model and the outcomes were annotated using the integrated model of health literacy.Data SourcesThe literature search was conducted using several electronic databases, including PubMed, EMBASE, CINAHL, Cochrane library and PsycINFO in December 2022.ResultsTen studies were selected for this systematic literature review. Seven studies were quantitative, two were qualitative and one was a mixed‐methods study. The four components of the health literacy interventions included empowering individuals with low‐health literacy (n = 10), strengthening individuals' social support system (n = 3), improving communication with health professionals (n = 1) and reducing barriers to access health systems (n = 3). No intervention addressed improving health professionals' health literacy competencies. Health literacy competencies identified as outcomes in the studies included access (n = 1), understand (n = 7), appraise (n = 1) and apply (n = 9) the health information.ConclusionsThe significant findings of this systematic literature review provide baseline data and evidence for developing health literacy interventions for people with disabilities. However, this review demonstrates that only a handful of intervention studies have addressed the low‐health literacy of people with disabilities. Further and more rigorous interventions addressing health literacy for people with diverse disabilities are warranted.ImpactThis review provides insights into how health literacy interventions can be tailored to the type of disability. Further, efforts should be expanded to comprehensively promote all the four core competencies of health literacy to reduce health disparities for individuals living with disabilities.No Patient or Public ContributionSystematic literature review.
Satisfaction with maternity triage following implementation of the Birmingham Symptom‐Specific Obstetric Triage System (BSOTS): Perspectives of women and staff
Authors: Vasilevski Vidanka , Ryan Denise , Crowe Grace , Askern Althea , McCormick Margie , Segond Stacey , Sweet Linda 
Published: July 2023

AbstractAimTo explore the satisfaction and experiences of women and staff with the BSOTS in an Australian hospital.DesignCross‐sectional descriptive survey.MethodsSurveys were distributed to women and staff between February and May 2022. Survey questions reflected satisfaction with triage and provision of care under the BSOTS system (for women) and confidence in using the BSOTS system and its impact on triage‐related care (for staff). Survey data were summarized using descriptive statistics, and qualitative responses were analysed using content analysis.ResultsThere were 50 women and 40 staff (midwives and doctors) survey respondents. Most women were satisfied with triage wait times, the verbal information they received and the time it took for them to receive care. Nearly all midwife participants indicated they had high knowledge and confidence in using the BSOTS. Most staff indicated that the BSOTS supported the accurate assessment of women and had benefits for women, staff and the hospital.ConclusionThe findings showed that women and staff were satisfied with receiving and providing care in a maternity triage setting under the BSOTS system.Implications for the Profession and/or Patient CareImplementing standardized maternity triage approaches such as the BSOTS in health settings delivering care to pregnant women is recommended for improving flow of care and perceptions of care quality by women.ImpactQuality of maternity triage processes is likely to impact the satisfaction of women attending services and the staff providing care. The BSOTS was shown to improve maternity triage processes and was associated with satisfaction of women and staff. Maternity settings can benefit from implementing triage approaches such as the BSOTS as it standardizes and justifies the care provided to women. This is likely to result in satisfaction of women and staff engaged in maternity triage and improve the birth outcomes of women and babies.Reporting MethodThe reporting of this paper has followed SQUIRE guidelines.Patient or Public ContributionWomen engaged with maternity services were participants in the study but did not contribute to the design, conduct or publication of the study.
Effects of electrolyzed water‐ultrasound treatment on pesticide removal in fresh‐cut potatoes with different cutting methods
Authors: Liu Yuan , Liu Zigang , Wang Jian , Liu Yang , Huang Yali , Zhu Xuran , Cheng Ming , Cao Jiayong , Liu Guangyang , Wan Yuping , Wang Jiying , Wu Xiaosheng 
Published: July 2023

AbstractElectrolyzed water (EW) and ultrasound (US) treatment are emerging effective means of reducing pesticides in fresh‐cut vegetables. However, their synergetic efficacy of degrading pesticides in fresh‐cut potatoes has not yet been revealed. Therefore, in this study, the effects of the combination of EW and US treatment on the removal of pesticides (chlorpyrifos, phorate, chlorothalonil, and procymidone) in fresh‐cut potato silks, strips, slices, and dices were investigated. Acidic electrolyzed water (AcEW) was selected as the optimum washing solution for pesticide removal on fresh‐cut potatoes. For the same type of fresh‐cut potato, the AcEW treatment with different sample‐to‐washing solution ratios showed no significant difference in the removal effect of different pesticides. The combined application of AcEW and US could efficiently reduce pesticides for different fresh‐cut potatoes. Furthermore, the optimal effects obtained varied greatly within the range of ultrasonic power 200–400 W and washing time 10–20 min. These results indicated that combining AcEW with US could serve as a promising method for pesticide reduction in fresh‐cut potatoes under respective appropriate process parameters.Practical ApplicationsPotato silks, strips, slices, and dices are the most common application form of fresh‐cut potatoes in Chinese dishes. Electrolyzed water (EW) and ultrasound (US) treatment have recently been used in reducing pesticides on fresh‐cut vegetables. However, their synergetic efficacy of degrading pesticides in fresh‐cut potatoes has not yet been revealed. This research provides a simple and novel method for pesticide removal on fresh‐cut potatoes. These steps combine Acidic electrolyzed water (AcEW) and US treatments to explore and improve the process parameters (sample‐to‐washing solution ratios, ultrasonic power, and washing time) of degrading pesticides for different fresh‐cut potatoes, including potato silks, strips, slices, and dices. Besides, the effect mechanism of different treatments on the degradation of pesticide residues was also discussed. The novel cleaning technology is expected to be popularized in vegetable processing plants.
A systematic review of consumer empowerment research trends: Evidence from esteemed consumer studies journals
Authors: Suk Jaehye , Li Xu , Hwang Hyesun 
Published: July 2023

AbstractResearch on consumer empowerment has evolved to reflect its requirements over time. This study aimed to trace consumer empowerment research trends through a systematic review of 245 abstracts from two esteemed journals in the field of consumer studies, namely, International Journal of Consumer Studies and Journal of Consumer Affairs. Reference network analysis revealed that research on consumer empowerment has been mainly focused on finance and education. Topic modeling revealed the following six topics: financial literacy education, school education, information competency, dietary behavior/nutrition, financial management competency, and empowerment in the market. Hot topics included financial literacy education and dietary behavior/nutrition, whereas school education was a cold topic. This study provides insights into consumer empowerment research trends and directions for future research.
Value fulfillment and well‐being: Clarifying directions over time
Authors: Hanel Paul H. P. , Tunç Hamdullah , Bhasin Divija , Litzellachner Lukas F. , Maio Gregory R. 
Published: July 2023

AbstractObjectiveWe investigate for the first time in a 9‐day diary study whether fulfilling one’s values predicts well‐being or whether well‐being predicts value fulfillment over time.BackgroundThe empirical associations between the importance of human values to individuals and their well‐being are typically weak and inconsistent. More recently, value fulfillment (i.e., acting in line with one's values) has shown to be more strongly correlated with well‐being.MethodThe present research goes beyond past research by integrating work from clinical, personality, and social psychology to model associations between value fulfillment and positive and negative aspects of well‐being over time.ResultsAcross a nine‐day diary study involving 1434 observations (N = 184), we found that people who were able to fulfill their self‐direction values reported more positive well‐being on the next day, and those who fulfilled their hedonism values reported less negative well‐being on the next day. Conversely, people who reported more positive well‐being were more able to fulfill their achievement, stimulation, and self‐direction values on the next day, and those who reported more negative well‐being were less able to fulfill their achievement values. Importantly, these effects were consistent across three countries/regions (EU/UK, India, Türkiye), the importance people attributed to values, period of the week, and their prestudy well‐being.ConclusionThese results help to understand the fundamental interconnections between values and well‐being while also having relevance to clinical practice.
High‐risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma
Authors: Caponio Vito Carlo Alberto , Zhurakivska Khrystyna , Mascitti Marco , Togni Lucrezia , Spirito Francesca , Cirillo Nicola , Lo Muzio Lorenzo , Troiano Giuseppe 
Published: July 2023

AbstractObjectivesHead and neck squamous cell carcinoma (HNSCC) poses a diagnostic and therapeutic challenge worldwide and is associated with a poor survival rate. Due to the variability in the efficacy of treatments for HNSCC, new predictive biomarkers of therapy outcomes are needed. Recently, we developed an algorithm that employs the mutational profile of TP53 as an independent prognostic factor in HNSCC. In this study, we investigated its role as a predictive biomarker of treatment outcomes in HNSCC patients. We also tested the usefulness of two classification systems for TP53 mutational landscapes.Materials and MethodsClinical and genomic data were retrieved from The Cancer Genome Atlas database. We built a multivariate stepwise backward binary regression model to assess the role of TP53 mutations in predicting therapeutic outcomes.ResultsCases harbouring high‐risk‐of‐death mutations reported an odds ratio of 3.301 for stable or progressive disease compared to wild‐type cases, while no significant difference in treatment outcomes was found between cases with low‐risk‐of‐death mutations and wild‐type TP53. Our analysis found that older patients with a history of alcohol consumption had a higher risk of stable/progressive disease.ConclusionsThis study improves current evidence on the role of TP53 mutations in treatment response in HNSCC patients.
Effects of regulatory burden and corruption on firm performance: Evidence from Moldova
Authors: Tan Shawn W. , Tusha Dea 
Published: July 2023

AbstractFirms in Moldova face a high level of regulatory burden, as proxied by the number of inspections by public authorities. At the same time, they face high levels of corruption. We examine the effect of frequent inspections on four measures of firm performance: labour and total factor productivity, and levels of tangible and intangible assets. We also investigate how corruption affects the relationship between inspections and firm performance. We perform panel data analysis using firm‐level administrative data and survey data from Moldova in 2005–2015. The results show that inspections and corruption each affect firm productivity negatively, but corruption moderates the negative effect of inspections. We also find that inspections and intangible assets are positively correlated, but this correlation is weaker for higher levels of corruption. Finally we examine whether these results differ by industry, firm size and ownership types. Inspections and corruption affect medium and large firms, and state‐owned enterprises differently from micro and small firms and private firms respectively.
Aspergillus spp. renal arteritis after kidney transplantation: A reappraisal
Authors: Gueneau Romain , Giret Chloé , Lafont Emmanuel , Buchler Matthieu , Longuet Hélène , Machet Marie‐Christine , Ghazzar Nadia , Lanternier Fanny , Lortholary Olivier 
Published: July 2023

AbstractBackgroundAspergillus spp. is an uncommon and life‐threatening cause of transplantrenal artery pseudoaneurysm after kidney transplantation.CaseWe report the case of a 62‐year‐old woman who underwent kidney transplantation 10 months before and presented a 7‐cm asymptomatic transplant renal artery pseudoaneurysm. Transplanted kidney and pseudoaneurysm were surgically removed in emergency. Renal graft, urine, and pseudoaneurysm cultures grew Aspergillus flavus. She recovered after 12 months of antifungal therapy.Literature reviewTo date 14 cases of Aspergillus spp. renal arteritis after kidney transplantation have been published, including 50% Aspergillus flavus arteritis. Vast majority were diagnosed within 90 days after transplantation (73%). Despite allograft nephrectomy and antifungal therapy, mortality rate was high (33%).
Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood
Authors: Chaban Ryan , McGrath Gannon , Habibabady Zahra , Rosales Ivy , Burdorf Lars , Ayares David L. , Rybak Elana , Zhang Tianshu , Harris Donald G. , Dahi Siamak , Ali Franchesca , Parsell Dawn M. , Braileanu Gheorghe , Cheng Xiangfei , Sievert Evelyn , Phelps Carol , Azimzadeh Agnes M. , Pierson Richard N. 
Published: July 2023

AbstractIntroductionExpression of human complement pathway regulatory proteins (hCPRP's) such as CD46 or CD55 has been associated with improved survival of pig organ xenografts in multiple different models. Here we evaluate the hypothesis that an increased human CD46 gene dose, through homozygosity or additional expression of a second hCPRP, is associated with increased protein expression and with improved protection from injury when GTKO lung xenografts are perfused with human blood.MethodsTwenty three GTKO lungs heterozygous for human CD46 (GTKO.heteroCD46), 10 lungs homozygous for hCD46 (GTKO.homoCD46), and six GTKO.homoCD46 lungs also heterozygous for hCD55 (GTKO.homoCD46.hCD55) were perfused with human blood for up to 4 h in an ex vivo circuit.ResultsRelative to GTKO.heteroCD46 (152 min, range 5–240; 6/23 surviving at 4 h), survival was significantly improved for GTKO.homoCD46 (>240 min, range 45–240, p = .034; 7/10 surviving at 4 h) or GTKO.homoCD46.hCD55 lungs (>240 min, p = .001; 6/6 surviving at 4 h). Homozygosity was associated with increased capillary expression of hCD46 (p < .0001). Increased hCD46 expression was associated with significantly prolonged lung survival (p = .048),) but surprisingly not with reduction in measured complement factor C3a. Hematocrit, monocyte count, and pulmonary vascular resistance were not significantly altered in association with increased hCD46 gene dose or protein expression.ConclusionGenetic engineering approaches designed to augment hCPRP activity — increasing the expression of hCD46 through homozygosity or co‐expressing hCD55 with hCD46 — were associated with prolonged GTKO lung xenograft survival. Increased expression of hCD46 was associated with reduced coagulation cascade activation, but did not further reduce complement activation relative to lungs with relatively low CD46 expression. We conclude that coagulation pathway dysregulation contributes to injury in GTKO pig lung xenografts perfused with human blood, and that the survival advantage for lungs with increased hCPRP expression is likely attributable to improved endothelial thromboregulation.