bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of intervertebral disc degeneration in young adult asymptomatic Dachshunds with magnetic resonance imaging and radiography
Authors: Reunanen Vilma Liisa Jerosa , Jokinen Tarja Susanna , Hytönen Marjo Kristiina , Junnila Jouni Juho Tapio , Lappalainen Anu Katriina 
Published: September 2023

Abstract
Background
Dachshunds have a high prevalence of intervertebral disc disease (IVDD) to which they are predisposed due to early intervertebral disc (IVD) degeneration and calcification. Moreover, the recently found 12-FGF4 retrogene (RG) is associated with calcified discs visible on radiographs (CDVR) and IVDD. Earlier studies suggest that all IVDs of one-year-old Dachshunds show signs of degeneration. This prospective, analytical, blinded study aimed to investigate the extent and distribution of IVD degeneration in young adult (24–31 months) asymptomatic Dachshunds (n = 21) hypothesizing that not all IVDs of two-year-old Dachshunds are degenerated. Another aim was to explore the correlations between IVD degeneration evaluated with magnetic resonance imaging (MRI), the number of CDVR, and the dog’s 12-FGF4RG status. The study protocol included grading the CDVR on spinal radiographs, grading the IVD degeneration on T2-weighted sagittal and transverse high-field MR images of all IVDs (n = 546), and 12-FGF4RG variant genotyping.

Results
Of all IVDs evaluated, 2% (n = 11) were normal based on MRI grading. Despite the study population having moderately degenerated IVDs (median MRI grade 3), there was also variation in the degree of IVD degeneration between individuals and in the distribution of IVD degeneration between different vertebral regions. The number of CDVR correlated significantly with the magnitude of IVD degeneration based on MRI evaluation and with the 12-FGF4RG genotype. The odds for being 12-FGF4RG homozygous were higher for Dachshunds with CDVR. However, the 12-FGF4RG variant did not alone explain the phenotypic variation in IVD degeneration.

Conclusions
The number of CDVR is a valid indicator of overall IVD degeneration, as it correlates with MRI-based IVD grading. Also, as the extent and distribution of IVD degeneration varies between individual Dachshunds, selective breeding against IVDD using radiographic screening and 12-FGF4RG variant genotyping is possible.
A study protocol for Project I-Test: a cluster randomized controlled trial of a practice coaching intervention to increase HIV testing in substance use treatment programs
Authors: Frimpong Jemima A. , Parish Carrigan L. , Feaster Daniel J. , Gooden Lauren K. , Nelson Mindy C. , Matheson Tim , Siegel Karolynn , Haynes Louise , Linas Benjamin P. , Assoumou Sabrina A. , Tross Susan , Kyle Tiffany , Liguori Terri K. , Toussaint Oliene , Annane Debra , Metsch Lisa R. 
Published: September 2023

Abstract
Background
People with substance use disorders are vulnerable to acquiring HIV. Testing is fundamental to diagnosis, treatment, and prevention; however, in the past decade, there has been a decline in the number of substance use disorder (SUD) treatment programs offering on-site HIV testing. Fewer than half of SUDs in the USA offer on-site HIV testing. In addition, nearly a quarter of newly diagnosed cases have AIDS at the time of diagnosis. Lack of testing is one of the main reasons that annual HIV incidences have remained constant over time. Integration of HIV testing with testing for HCV, an infection prevalent among persons vulnerable to HIV infection, and in settings where they receive health services, including opioid treatment programs (OTPs), is of great public health importance.

Methods/design
In this 3-arm cluster-RCT of opioid use disorders treatment programs, we test the effect of two evidence-based “practice coaching” (PC) interventions on the provision and sustained implementation of on-site HIV testing, on-site HIV/HCV testing, and linkage to care. Using the National Survey of Substance Abuse Treatment Services data available from SAMHSA, 51 sites are randomly assigned to one of the three conditions: practice coach facilitated structured conversations around implementing change, with provision of resources and documents to support the implementation of (1) HIV testing only, or (2) HIV/HCV testing, and (3) a control condition that provides a package with information only. We collect quantitative (e.g., HIV and HCV testing at 6-month-long intervals) and qualitative site data near the time of randomization, and again approximately 7–12 months after randomization.

Discussion
Innovative and comprehensive approaches that facilitate and promote the adoption and sustainability of HIV and HCV testing in opioid treatment programs are important for addressing and reducing HIV and HCV infection rates. This study is one of the first to test organizational approaches (practice coaching) to increase HIV and HIV/HCV testing and linkage to care among individuals receiving treatment for opioid use disorder. The study may provide valuable insight and knowledge on the multiple levels of intervention that, if integrated, may better position OTPs to improve and sustain testing practices and improve population health.

Trial registration
ClinicalTrials.gov NCT03135886. Registered on 2 May 2017.
Cross-cultural adaptation of the Parental Perceptions of Children’s Exposure to Tobacco Smoke instrument to the Brazilian context
Authors: Tavares Maria Alice Santos , Myers Vicki , Nogueira Leandro Alberto Calazans , Lopes Agnaldo José 
Published: September 2023

Abstract
Objective
To perform a cross-cultural adaptation of the Parental Perceptions of Children’s Exposure to Tobacco Smoke (PPE) instrument to the Brazilian context.

Results
The cross-cultural adaptation process was performed in 10 stages. Four translators, eight specialists, and 35 primary care users participated in the study. Both translations were similar. The synthesis version that was back-translated was equivalent to the original. The committee of experts scored all items in the content validity index as 3 or 4, suggesting only small changes such as changing “photo” to “image” and “service balcony” to “service area”. After the completion of the first sequence of pretests, some adjustments were required by the committee of experts for the second round. The form of application of the self-administered questionnaire for the interview was changed, the Likert scale was reduced from 7 to 5 points, and the option “I don’t know” was added to questions 18, 19, and 20. After these adjustments, the instrument was well accepted by the study population and presented good internal consistency (Cronbach’s α score = 0.82). The PPE instrument, which assesses the perception of parents about their children’s exposure to cigarette smoke, was satisfactorily translated and adapted to the Brazilian context.
Hematological entities with plasmacytic differentiation: a case report
Authors: Inamdar Arati , Bhattacharyya Siddharth 
Published: September 2023

Abstract
Introduction
Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never been reported and is a diagnostic challenge considering other differential diagnoses.

Case presentation
We present the case of a 51-year-old African-American female with progressively increasing cough, dyspnea, and dysphagia for 6 months with a computed tomography (CT) scan revealing a subcarinal mass. The histopathological analysis of the mass reveals a diagnosis of lymphoma with plasma cell differentiation, with a differential of lymphoplasmacytic lymphoma and plasma cell neoplasm. The lymphoma panel via next-generation sequencing (NGS) and a myeloma-targeted fluorescent in situ hybridization (FISH) panel confirmed the diagnosis of IgM extramedullary plasmacytoma, an entity of rare occurrence. Treatment with radiation led to complete regression of the plasmacytoma with normal blood work-up.

Conclusions
This report describes the challenges of diagnosing IgM extramedullary plasmactyoma. Our case report highlights the importance of cytogenetics and NGS in establishing a correct diagnosis that indeed has prognostic and therapeutic implications.
Autoimmune bullous disorder flares following severe acute respiratory syndrome coronavirus 2 vaccination: a case series
Authors: Rasner Cody J. , Schultz Brittney , Bohjanen Kimberly , Pearson David R. 
Published: September 2023

Abstract
Background
Autoimmune bullous disorders develop due to autoantibodies targeting intercellular adhesion proteins of hemidesmosomes and desmosomes and may be triggered by viral infections and vaccines. Recent reports suggest that the coronavirus disease 2019 vaccination may trigger flares or exacerbations of preexisting autoimmune diseases, including new onset autoimmune bullous disorders. There are less data on whether vaccination against severe acute respiratory syndrome coronavirus 2 may also exacerbate preexisting autoimmune bullous disorders.

Case presentation
Here we present three cases, two white males (ages 69 years and 88 years) with bullous pemphigoid and one white 50-year-old female with pemphigus foliaceus, wherein all individuals developed minor, tractable flares of their preexisting autoimmune bullous disorders after receiving the coronavirus disease 2019 vaccination, which were readily treatable with topical or low-dose systemic corticosteroids.

Conclusions
Dermatologists managing patients with autoimmune bullous disorders should be cognizant of the uncommon potential for flares of the disorder following vaccination for severe acute respiratory syndrome coronavirus 2. Flares of bullous pemphigoid and pemphigus foliaceus following vaccination for severe acute respiratory syndrome coronavirus 2 in these cases were mild and tractable.
Modeling and analysis for group delay mismatch effect on wideband adaptive spatial interference cancellation
Authors: Zhang Yunshuo , He Fangmin , Liu Hongbo , Li Yaxing , Yang Zhong , Wang Ze , Meng Jin 
Published: September 2023

AbstractThe adaptive interference cancellation technique has been widely utilized in radar, GPS, data link, etc., systems to address challenges from external interference, such as co-site and hostile interference. Since the anti-jamming performance of the adaptive interference cancellation technique is sensitive to group delay mismatch between channels, the group delay mismatch becomes one of the main factors that limit the system’s anti-jamming capability. However, the traditional adaptive interference cancellation system’s mathematical model cannot quantitatively characterize the group delay mismatch effect on the wideband interference cancellation performance. In this paper, the mathematical model of the wideband adaptive spatial interference cancellation (ASIC) system is established, which considers the group delay mismatch, to quantitatively analyze the impact of group delay mismatch on the hostile interference cancellation. The mathematical model utilizes the weighted multi-tone signals to fit the wideband interference, and then, delay differences are attached to each tone signal to simulate the group delay mismatch. Then, the analytic expressions of weight and interference cancellation ratio are derived, which consider the interference bandwidth and group delay mismatch, to quantitatively analyze the group delay mismatch effect on the anti-jamming performance of the wideband ASIC system. Simulation results indicate that the theoretical analysis based on the mathematical model of wideband ASIC system are accurate, which can achieve the quantitative analysis of the group delay mismatch effect on the WIC performance.
Hermite-Hadamard type inequalities for multiplicatively p-convex functions
Authors: Özcan Serap 
Published: September 2023

AbstractIn this paper, we introduced the concept of multiplicatively p-convex functions and established Hermite-Hadamard type integral inequalities in the setting of multiplicative calculus for this newly created class of functions. We also gave integral inequalities of Hermite-Hadamard type for product and quotient of multiplicatively p-convex functions. Furthermore, we obtained novel multiplicative integral-based inequalities for the product and quotient of convex and multiplicatively p-convex functions. Additionally, we derived certain upper limits for this new class of functions. The findings we proved are generalizations of the results in the literature. The results obtained in this study may inspire further research in various scientific areas.
Wheat seedling extract and its constituents attenuate RANKL-induced differentiation and fusion of osteoclasts and bone resorption
Authors: Lee HanGyeol , Yang Ji-Yeong , Kim Shin-Hye , Lim So-An , Kim Jae Kwang , Kang Chon-Sik , Kim Kyeong-Hoon , Choi Sik-Won , Seo Woo Duck 
Published: September 2023

AbstractThe occurrence of osteoporosis gradually increases within the aging population. As the side effects of therapeutic agents currently used for osteoporosis are increasing, the development of preventive and therapeutic agents derived from natural products without any long-term side effects is important. Here, we investigated the effect of wheat seedling extract (WSE) on the RANKL-mediated differentiation, fusion, and function of osteoclasts. WSE inhibited the differentiation of RANKL-induced bone marrow macrophages and phosphorylation of AKT and ERK. Moreover, the protein and mRNA expression levels of c-Fos and NFATc1 as well as RANKL-induced transcription of TRAP and OSCAR were suppressed by WSE treatment. DC-STAMP and cathepsin K, which are essential for cell fusion and bone degradation, were also inhibited by WSE. Furthermore, eight components constituting WSE were confirmed to decrease the osteoclast TRAP activity. Taken together, WSE may have potential implications as a useful therapeutic or preventive agent for inhibition of bone loss.
Meningiomas in patients with neurofibromatosis type 2 predominantly comprise ‘immunogenic subtype’ tumours characterised by macrophage infiltration
Authors: Teranishi Yu , Miyawaki Satoru , Nakatochi Masahiro , Okano Atsushi , Ohara Kenta , Hongo Hiroki , Ishigami Daiichiro , Sakai Yu , Shimada Daisuke , Takayanagi Shunsaku , Ikemura Masako , Komura Daisuke , Katoh Hiroto , Mitsui Jun , Morishita Shinichi , Ushiku Tetsuo , Ishikawa Shumpei , Nakatomi Hirofumi , Saito Nobuhito 
Published: September 2023

AbstractAlthough recent molecular analyses revealed that sporadic meningiomas have various genetic, epigenetic, and transcriptomic profiles, meningioma in patients with neurofibromatosis type 2 (NF2) have not been fully elucidated. This study investigated meningiomas' clinical, histological, and molecular characteristics in NF2 patients. A long-term retrospective follow-up (13.5 ± 5.5 years) study involving total 159 meningiomas in 37 patients with NF2 was performed. Their characteristics were assessed using immunohistochemistry (IHC), bulk-RNA sequencing, and copy number analysis. All variables of meningiomas in patients with NF2 were compared with those in 189 sporadic NF2-altered meningiomas in 189 patients. Most meningiomas in NF2 patients were stable, and the mean annual growth rate was 1.0 ± 1.8 cm3/year. Twenty-eight meningiomas (17.6%) in 25 patients (43.1%) were resected during the follow-up period. WHO grade I meningiomas in patients with NF2 were more frequent than in sporadic NF2-altered meningiomas (92.9% vs. 80.9%). Transcriptomic analysis for patients with NF2/sporadic NF2-altered WHO grade I meningiomas (n = 14 vs. 15, respectively) showed that tumours in NF2 patients still had a higher immune response and immune cell infiltration than sporadic NF2-altered meningiomas. Furthermore, RNA-seq/IHC-derived immunophenotyping corroborated this enhanced immune response by identifying myeloid cell infiltration, particularly in macrophages. Clinical, histological, and transcriptomic analyses of meningiomas in patients with NF2 demonstrated that meningiomas in NF2 patients showed less aggressive behaviour than sporadic NF2-altered meningiomas and elicited a marked immune response by identifying myeloid cell infiltration, particularly of macrophages.
The synergic impacts of salt mixture and frost damage on rock decay: implications for the deterioration of rock-hewn heritages
Authors: Wang Yinghong , Zhang Hui 
Published: September 2023

Abstract
Soluble salt and freeze–thaw are two significant weathering factors that contribute to the deterioration of rock-hewn heritages. Previous research has predominantly focused on the separate influences of salt weathering and freeze–thaw. However, in a realistic scenario, these two processes can occur simultaneously in nature, leading to a more complex decay process for such heritage. The aim of this study was to assess the combined impact of salt weathering and freeze–thaw on the severity of deterioration in rock-hewn heritage through evaluation of the variation of stone samples’ appearance and physical–mechanical properties, such as deterioration patterns, pore structure, surface hardness and splitting tensile strength. A laboratory ageing test was conducted using materials and climatic conditions representative of the West Lake Cultural Landscape of Hangzhou (WLCL), a UNESCO World Heritage Site located in Southeast China. Five different types of stones were collected from the WLCL area and its vicinity and subjected to 25 ageing cycles, each consisting of three phases: salt impregnation, freezing-thaw, and evaporation. The mixture of

$${{Na}_{2}SO}_{4}{-MgSO}_{4}$$

Na

2

S
O

4

-
M
g
S
O

4

was used as the contaminant substance. Results show that stones with moderate porosity (~ 5%) and a higher proportion of micropores, like flint, were susceptible to the combined effects of salt weathering and freeze–thaw, exhibiting significant surface deformation and strength decline. The porous tuff was primarily impacted by the development of a hard and thick crust on its surface, along with noticeable pore fill. The compact carbonate rock exhibited limited dimensional expansion with no discernible signs of deterioration patterns. Most rock specimens, except tuff, experienced a shift in their pore size distribution towards larger magnitudes, resulting in an increased average pore radius. This suggests that the inherent properties of rock-hewn heritages play a significant role in determining their vulnerability to various weathering agents. Consequently, these properties should serve as the foundation for developing future preventive conservation measures.

Graphical Abstract
A guide to creating an effective big data management framework
Authors: Arundel S. T. , McKeehan K. G. , Campbell B. B. , Bulen A. N. , Thiem P. T. 
Published: September 2023

AbstractMany agencies and organizations, such as the U.S. Geological Survey, handle massive geospatial datasets and their auxiliary data and are thus faced with challenges in storing data and ingesting it, transferring it between internal programs, and egressing it to external entities. As a result, these agencies and organizations may inadvertently devote unnecessary time and money to convey data without existing or outdated standards. This research aims to evaluate the components of data conveyance systems, such as transfer methods, tracking, and automation, to guide their improved performance. Specifically, organizations face the challenges of slow dispatch time and manual intervention when conveying data into, within, and from their systems. Conveyance often requires skilled workers when the system depends on physical media such as hard drives, particularly when terabyte transfers are required. In addition, incomplete or inconsistent metadata may necessitate manual intervention, process changes, or both. A proposed solution is organization-wide guidance for efficient data conveyance. That guidance involves systems analysis to outline a data management framework, which may include understanding the minimum requirements of data manifests, specification of transport mechanisms, and improving automation capabilities.
Cystitis: significant associations between pathology, histology, and quantitative bacteriology in sows, a cross-sectional study
Authors: Tolstrup Lola Kathe , Leifsson Páll Skúli , Guardabassi Luca , Nielsen Jens Peter , Pedersen Ken Steen 
Published: September 2023

Abstract
Background
The importance of cystitis in pig production is controversial and sparse information is available on its frequency and etiology in sows. The aim of this study was to determine the prevalence of bacteriuria, macroscopical and histological lesions of the urinary bladder in culled sows. Urinary bladders and urine samples were obtained from 176 culled sows at slaughter. The urine samples collected by cystocentesis were analyzed to determine bacterial content and pathological findings, macroscopic as well as microscopic, of the bladder were recorded for each sow.

Results
The prevalence of bacteriuria, defined by bacterial concentrations ≥ 103 colony forming units per mL of urine, was 34%. Escherichia coli was isolated from 69% of the samples with bacteriuria. Redness of the mucosa was the most frequently observed macroscopic change of the bladder. Intense redness and presence of pus was considered significant pathological changes and occurred in 27% of the urinary bladders. The histopathological examination showed that mononuclear cells were the predominant type of cell infiltration in the bladder mucosa, while neutrophils occurred in very few samples. The criteria for cystitis determined by histopathology were met in 46% of the samples. The criteria were based on presence of hyperemia, edema, and inflammatory cell reaction defined as 40 or more neutrophils or mononuclear cells per high power field. All three indicators of cystitis were significantly associated with each other (p < 0.05) at sow level.

Conclusion
This study shows that signs of cystitis are common in culled sows. The prevalence of cystitis was 34% based on bacteriological examination, 27% based on macroscopic examination and 46% based on histological examination. Significant associations were found between the three indicators of cystitis: bacteriuria, pathological and histological lesions of the bladder. Based on macroscopic changes and histopathology of the bladder, the cut-off of ≥ 103 colony forming units per mL of urine seems to be appropriate for assessing urine cultures obtained by cystocentesis.