bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of the Voltage‐Gated Potassium Channel by Amphiphilic Glycopeptides
Authors: Anand Saurabh , Bandyopadhyay Sucheta , Ravindra Bhoge Preeti , Toraskar Suraj , Kalia Jeet , Kikkeri Raghavendra 
Published: January 2025

AbstractVoltage‐gated ion channels (VGICs) are allosterically modulated by glycosaminoglycan proteoglycans and sialic acid glycans. However, the structural diversity and heterogeneity of these biomolecules pose significant challenges to precisely delineate their underlying structure‐activity relationships. Herein, we demonstrate how heparan sulfate (HS) and sialic acid synthetic glycans appended on amphiphilic glycopeptide backbone influence cell membrane persistence and modulate the gating of the Kv2.1 channel. Utilizing a panel of amphiphilic glycopeptides comprising HS disaccharides and sialic acid trisaccharide glycans, we observed that sulfation of HS and flexible α(2‐6) sialylation result in prolonged persistence of glycopeptides on the cell membrane compared to non‐sulfated HS and α(2–3) sialylation respective. This variation in glycocalyx composition was associated with a noticeable difference in the effects of these compounds on the activation and deactivation properties of the voltage‐gated Kv2.1 channel with our strongest membrane associating compound demonstrating the most potent channel‐activation propensity. Our findings demonstrate that sulfation charges on glycopeptide play a critical role in their membrane association propensities and endow them with VGIC activation properties. These results provide a valuable insight into the role of cell surface glycans in VGIC activities.
Noble‐Metal‐Free Electrocatalysts for Selective Hydrogen Peroxide Generation via Oxygen Reduction Reaction
Authors: Liu Yuepeng , Lei Fang , Li Tingting , Wang Siyu , Li Yi 
Published: January 2025

AbstractHydrogen peroxide (H2O2) is a versatile chemical widely used in various industries. The traditional anthraquinone method for H2O2 synthesis has environmental and safety concerns due to the use of organic solvents and hazardous by‐products. The direct synthesis of H2O2 from H2 and O2 poses risks of flammability and explosion. Recently, the 2‐electron oxygen reduction reaction (2e− ORR) method has emerged as a promising alternative, offering safety, environmental friendliness, and cost‐effectiveness. This method utilizes gas diffusion electrodes to efficiently generate H2O2 without the need for additional dilution. In this review, we focus on the recent advancements in noble‐metal‐free materials for 2e− ORR electrocatalysis, which play a crucial role in the efficient production of H2O2. These materials, including transition metal compounds, macrocyclic complexes, carbon‐based catalysts, framework materials, and MXenes catalysts, demonstrate significant advantages in enhancing H2O2 yield. The development of these non‐precious metal catalysts can reduce costs and improve sustainability and promote the commercialization of related technologies. The review concludes with an outlook on the future trends of 2e− ORR electrocatalysts.
Diversity‐Oriented Synthesis and Antibiofilm Evaluation of Furan‐2‐Carboxamides
Authors: Muñoz‐Estrada Ana C. , Tovar‐Roman Cesar E. , García‐Mejía Carlos D. , García‐Contreras Rodolfo , Hernández‐Vázquez Eduardo 
Published: January 2025

AbstractA diversity‐oriented collection of furan‐2‐carboxamides with antibiofilm activity against P. aeruginosa is reported. The design involved the bioisosteric replacement of the labile furanone ring by a furan‐2‐carboxamide moiety to explore its influence on biological activity. After evaluation, carbohydrazides and triazoles showed significant antibiofilm activity, and 4b resulted in the most remarkable compound (58 % inhibition). Furthermore, treating P. aeruginosa with three active carboxamides reduced some virulence factors (pyocyanin and proteases), confirming the anti‐quorum sensing properties of the derivatives and suggesting LasR as a plausible target. Molecular docking proposed that carbohydrazides share a similar binding mode to related furanones inside LasR with an excellent docking score, while higher derivatives diminished in silico affinity.
Recent Advances in Heterogenization of Photocatalysts on Polymer Supports and Applications in Organic Synthesis
Authors: Delacourt Cloé , Goddard Jean‐Philippe , Spangenberg Arnaud , Cormier Morgan 
Published: January 2025

AbstractThe photocatalysis is a powerful tool in organic synthesis to generate reactive intermediates and create challenging chemical bonds. The reactivity on such process is mainly controlled by a photocatalyst (PCat) which is designed to ensure both selectivity and efficiency. In the pursuit of more economical and environmentally friendly approaches, the heterogenization of photocatalysts has become increasingly essential, and it is still challenging. Among the various insoluble supports studied, polymers offer several appealing characteristics, such as stability, ease of synthesis, porosity, and recyclability. This review aims to summarize the recent progress in heterogenization of photocatalyst on polymer including the polymerization of PCat, post‐grafting of PCat and 3D‐printing. For the selected heterogeneous photocatalyst, examples of organic transformations and evidence of photocatalytic efficiency will be discussed.
Like Parent, Like Subsidiary? On the Diffusion of Sustainability Reporting in Multinational Companies
Authors: Fourati Abdelaziz , Zenaidi Amel , Jeriji Maher 
Published: January 2025

ABSTRACTThis research investigates the determinants of sustainability reporting practices within multinational companies (MNCs) and their subsidiaries, focusing on the mediating role of MNC parents and the moderating impact of cultural distance and local isomorphism. We conducted a content analysis of the stand‐alone sustainability reports of 187 MNCs and 332 subsidiaries over a decade (2011–2020), comparing 1594 subsidiary reports with 983 parent reports. A path analysis approach assessed the mediating role of MNC parents, while random effects panel models assessed the moderating effects of local isomorphism and cultural distance. The results indicate that MNC parents positively and significantly influence the adoption of sustainability reporting practices by their subsidiaries. However, the successful implementation of these practices is moderated by local institutional context and cultural distance. Subsidiary transparency was positively influenced by industry characteristics and effective local governance, while financial constraints and the degree of alignment with international standards played a complex role in reporting practices. Our research indicates that MNCs need to adjust their global approaches to fit into local environments and improve the transparency of subsidiaries by utilizing industry‐specific tactics and robust local management. Policymakers need to prioritize enhancing local governance structures to improve sustainability reporting. This research contributes to the field of institutional theory by demonstrating how local isomorphism affects the dissemination of reporting practices within MNCs. Furthermore, it is one of the few recent studies to examine sustainability reports in‐depth, analyzing their content and assessing the extent to which cultural distance affects the adoption of transparency practices global.
Alliance Networks, Innovative Culture, and Intellectual Human Capital as Key Enablers of Corporate Social Innovation: A Hybrid Approach Using PLS‐SEM and fsQCA
Authors: Abbasi Munir A. , Yon Lim Chia , Amran Azlan 
Published: January 2025

ABSTRACTCorporations have been increasingly prioritizing corporate social innovation (CSI). It has potential for creating long‐term business value and promoting sustainable social development. CSI possesses immense value due to its exceptional ability to tackle complex and pressing social issues. Despite over a decade of research on CSI, there is limited understanding about drivers of CSI from the perspective of organizational resources. The current study utilized the resource‐based view of the firm (RBV) to investigate the impact of organizational resources (such as alliance networks, innovative culture, and intellectual human capital) on CSI. This was done by examining the mediation of dynamic capabilities (exploitation and exploration). The data obtained from Malaysian public limited companies was examined using PLS‐SEM and fsQCA. The results revealed that alliance networks and innovative culture play a crucial role to drive CSI. The fsQCA analysis discovered four sufficient configurations that foster CSI. In addition to the theoretical contributions, the findings have significant implications for corporate leaders seeking CSI initiatives, as well as policy makers within governmental bodies.
Drought Adaptation and Responses of Stipa krylovii Vary Among Different Regions: Evidence From Growth, Physiology, and RNA‐Seq Transcriptome Analysis
Authors: Gong Ziqing , Qu Zehang , Liu Yulin , Wang Tao , Fan Baijie , Ren Anzhi , Gao Yubao , Zhao Nianxi 
Published: January 2025

ABSTRACTIn the context of global climate change, exploring how plant adaptation and responses to drought vary among different regions are crucial to understanding and predicting its geographic distribution. In this study, to explore the drought adaptation and responses of the dominant species in the semi‐arid Eurasian Steppes and their differences among the different regions in terms of growth, physiology, and RNA‐seq transcriptome, Stipa krylovii was chosen as the study material, and a seed source (three regions: eastern, middle, and western regions) × soil moisture treatment (three treatments: control, light drought, and heavy drought) two‐factor experiment was conducted. (1) Four growth traits for individuals from the western region were significantly lower than those from the other two regions. By Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis on gene expressions of individuals from each treatment, unique enriched pathways were found under heavy drought. (2) The decrease in the number of tillers with the increasing drought was much lower for individuals from the western region than those from the other two regions. The differentially expressed genes (DEGs) of individuals from the eastern, middle, and western regions between heavy drought versus control were 4887, 1900, and 4896. By KEGG functional enrichment analysis, individuals from the eastern and middle regions mainly regulated energy metabolism and metabolism of other amino acids; and those from the western region mainly regulated biosynthesis of other secondary metabolites and carbohydrate metabolism. (3) Clustering analysis based on gene expressions separated the western region from the other two regions under the same drought treatment. This study indicates that drought adaptation and responses of S. krylovii vary among different regions, especially between individuals from the western region and the other two regions. These findings are essential to understanding the adaptive evolution of population and germplasm resource protection for this important species.
Sexual dimorphic effects of a keystone predator on prey communities
Authors: Davenport Jon M. , Babineau Alan M. , Sloan Reese K. , Groesbeck Autumn , Montazeri Ali J. , Ramey Maxwell 
Published: January 2025

AbstractThe importance of trait variation has long been recognized in ecological and evolutionary research. The divergence of sexually dimorphic traits (e.g., body size, morphology, behavior, etc.) is primarily attributed to sexual selection, and sexual dimorphism can have consequences for diets and habitat use. Recent evidence for one aquatic predator species (adult newts; Notophthalmus viridescens) suggests that trait differences and habitat partitioning between the sexes may be important in structuring zooplankton communities. However, newts are known to increase amphibian diversity within pond communities via keystone predation. Yet, no data are available on differentiating potentially sexually dimorphic effects of newts on larval amphibian communities. Thus, we conducted a series of mesocosm experiments to determine the effects of sexual dimorphism of adult newts on larval amphibian communities. Based on previous work with newts and zooplankton, we hypothesized that male and female newts would have differing effects on prey communities. We found that female newts consumed one prey species more than male newts did and no newt treatments. There were no differences between the sexes in prey consumption of another prey species. Size at metamorphosis was greater in the presence of newts (either male or female) for wood frogs and in the presence of female newts for spotted salamanders in comparison with no newt treatments. Our findings indicate that sexual dimorphism within a known keystone predator can have differential effects on prey. Indeed, our results indicate that while the effects of predators on one response (survival) can differ between sexes, the impacts on another response (prey fitness; measured as size at metamorphosis) were similar. Our research to understand the effects of sexual dimorphism is timely as sex ratios of predators may become skewed in nature due to anthropogenic change. If intraspecific differences exist via top‐down effects, then downstream impacts on prey communities may go unnoticed.
Anti‐GAD65 musicogenic epilepsy: Bilateral and independent mesial temporal seizures revealed by foramen ovale electrodes
Authors: Di Giacomo Roberta , Maccanti Giulia , Gnatkovsky Vadym , Vatti Giampaolo , Parente Annalisa , Dominese Ambra , Sebastiano Davide Rossi , Doniselli Fabio Martino , Andreetta Francesca , Stabile Andrea , Deleo Francesco , Pastori Chiara , Battaglia Giulia , Duran Dunja , Didato Giuseppe , Del Sole Angelo , Rizzi Michele , de Curtis Marco 
Published: January 2025

AbstractMusicogenic epilepsy (ME) is characterized by seizures triggered by music. The epileptogenic focus in this rare reflex epilepsy is often in the temporal lobe, although the precise localization is still unclear. A correlation between ME and the presence of GAD65 antibodies indicates a potential immunological pathogenic mechanism. We evaluated a 32‐year‐old woman with drug‐resistant temporal lobe epilepsy as a candidate for epilepsy surgery. In the absence of clear clinical lateralizing signs, video‐EEG monitoring with intracranial electrodes inserted through the foramen ovale was performed to record from the amygdalo‐hippocampal regions. The foramen ovale electrodes revealed bilateral, asynchronous, and independent seizure onsets in the mesial temporal regions triggered by music. Testing for GAD65 antibodies confirmed high‐titer positivity. The efficacy of epilepsy surgery in antiGAD65‐positive ME patients remains limited. We highlight the use of semi‐invasive recording with foramen ovale electrodes in ME, as it can reveal bilateral seizures of mesial origin that contraindicate surgery and support the consideration of immunotherapy options.Plain Language SummaryMusicogenic epilepsy is a type of epilepsy in which music triggers seizures. Our understanding of its origin and cause is still limited. We assessed a patient with music‐induced seizures to see if surgery was an option. Since noninvasive tests before surgery were not clear, we used a minimally invasive method with electrodes inserted through a small opening in the skull called the foramen ovale to record the seizures. Thus, we found that the seizures started independently from both temporal lobes, contraindicating epilepsy surgery. We also found high levels of GAD65 antibodies indicating an immunological pathogenic mechanism.
Do Price Jumps Matter in Volatility Forecasts of US Treasury Futures?
Authors: Zhang Xueer , Hung Jui‐Cheng , Chiu Chien‐Liang 
Published: January 2025

ABSTRACTThis study investigates volatility forecasts in the US Treasury futures market and emphasizes the importance of price jumps across various maturities under moderate and sharp interest rate rising scenarios. We assess out‐of‐sample forecasting performance not only with statistical method but economic method based on a volatility timing strategy. Our findings indicate that models including price jumps specifications exhibit substantial enhancements in both evaluation methods over the entire out‐of‐sample period, particular for the period of sharp interest rate rising. Our results are robust to nonparametric jump tests used in this study, transaction costs, and portfolio rebalancing method.
Assessing longitudinal prenatal knowledge and skills retention among community birth attendants enrolled in a novel school
Authors: Bellon Margot , Brody Annalie , Parker Mahdia , Mendoza Ana Leticia , Hernandez Sasha , Clarke Rachel D. , Shirazian Taraneh , Oliveira Jessica B. 
Published: January 2025

AbstractObjectiveGuatemala has one of the highest rates of maternal mortality in Central America. A total of 60% of births in Guatemala are attended by traditional Mayan birth attendants, or comadronas. Their prevalence in these communities makes them a valuable resource to bridge home births with safe prenatal care. The objective of this study was to evaluate a low‐cost prenatal care training program for Guatemalan comadronas with the goal of improving maternal health outcomes in the region.MethodsIn this retrospective longitudinal cohort study, we examined the knowledge retention of comadronas enrolled in a 12‐month prenatal care training program known as the School of PowHER (SOP). Recruited from the Lake Atitlán region of Guatemala by Saving Mothers, 501(c)(3) and the Guatemalan Ministry of Health, comadronas participated in a four‐month didactic curriculum followed by a nine‐month clinical curriculum. Pre‐ and post‐tests were administered to assess learning outcomes over the study's duration (2014–2022), and test results were evaluated to assess the effectiveness of the SOP.ResultsA total of 123 women were recruited and enrolled in all eight graduating classes of the SOP from 2014, 2016–2019, and 2021–2022. An average, statistically significant improvement in didactic and clinical pre‐ and post‐test scores was found across all years analyzed.ConclusionThe SOP is a low‐cost, culturally appropriate, community‐based model that empowers comadronas through knowledge and skill acquisition to improve local maternal health outcomes. This program proves effective at not only teaching comadronas prenatal health information and clinical skills, but also at promoting long‐term retention of these skills.
Cell death: The underlying mechanisms of photodynamic therapy for skin diseases
Authors: Li Haoxin , Shen Jingjie , Zheng Chunfu , Zhu Ping , Yang Hong , Huang Yixiao , Mao Xinru , Yang Zhilu , Hu Guodong , Chen Yinghua 
Published: January 2025

AbstractPhotodynamic therapy (PDT) has significant potential in the treatment of dermatological, oncological, and nonneoplastic conditions through the induction of cell death, immune regulation, antimicrobial effects, etc. However, the response of some patients is unsatisfactory, and there is a lack of an ideal protocol for multiple specific diseases (subtypes) to choose the proper photosensitizer (PS), light source, and dose. A thorough understanding of the underlying mechanism is integral to solving these problems, and cell death has gained much attention. In addition to apoptosis, autophagy, and necrosis, several novel cell death pathways, such as necroptosis, mitotic catastrophe, paraptosis and pyroptosis, have been reported in PDT treatment. The type of induced cell death depends on the dose of PDT, the subcellular location of PSs, and the regulation of signaling pathways. In addition, different types of cell death induced by the same type of PDT, such as apoptosis and autophagy, may interact with each other. Some types of cell death can also trigger immunogenic cell death (ICD), which can ignite an immune response against antigens derived from dying/dead cells and present improved antitumor effects. On the basis of these mechanisms, several strategies, such as targeted PSs, PDT combined with immunotherapy and ICD‐based vaccines, have been proposed to improve therapeutic efficacy. Future studies are needed to elucidate the relationship between cell death and therapeutic effects and to shed new light on the exploration of precise PDT for specific patients.
Reprogramming of Fatty Acid Metabolism in Acute Leukemia
Authors: Sokei Judith , Kanefsky Joice , Sykes Stephen M. 
Published: January 2025

ABSTRACTFatty acids are essential biomolecules that support several cellular processes, such as membrane structures, energy storage and production, as well as signal transduction. Accordingly, changes in fatty acid metabolism can have a significant impact on cell behavior, such as growth, survival, proliferation, differentiation, and motility. Therefore, it is not surprising that many aspects of fatty acid metabolism are frequently dysregulated in human cancer, including in highly aggressive blood cancers such as acute leukemia. The aims of this review are to summarize the aspects of fatty acid metabolism that are specifically coopted in acute leukemia as well as current preclinical strategies for targeting fatty acid metabolism in these cancers.
Putting Nose into Reproduction: Influence of Nasal and Reproductive Odourant Signaling on Male Reproduction
Authors: Elango Kamaraj , Kekäläinen Jukka 
Published: January 2025

ABSTRACTOdourant receptors (ORs) are not restricted only to the nose, but also occur in many other organs and tissues, including the reproductive system. In fact, ORs are the most heavily expressed in testis than in any other extra‐nasal tissue. Accumulating evidence suggests that olfactory and reproductive systems are both structurally and functionally linked and that these interconnections can influence various aspects of reproduction. In this article, we first review our current understanding of these interconnections and then collate accumulated evidence on the presence of ORs in the male reproductive system and sperm cells. We then investigate the potential role of female reproductive tract odourants in sperm chemotaxis and selection. Finally, since the existing evidence especially for sperm odor sensing capability and its physiological function are controversial, we also review potential reasons for the controversy and propose some ways to resolve the debate. Collectively, we conclude that reproductive odourant signaling may play an important, although currently largely unclear role in many key processes directly related to male fertility. However, since we lack holistic understanding of the functional significance of ORs and odor sensing pathways of the male reproductive system, more empirical research is warranted.