bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Surgical treatment of McCune-Albright syndrome with hyperthyroidism and retrosternal goiter: A case report and literature review
Authors: Xing Zhiwei , Tao Gongshuai , Pan Wanwan , Wu Delin , Pan Tingting , Wan Lingfeng , Ma Xiaopeng , Wang Yangyi 
Published: January 2023

IntroductionMcCune-Albright syndrome (MAS) is a low-incidence syndrome consisting of the clinical triad of fibrous structural dysplasia of bone, endocrine disease, and skin pigmentation. Thyroid dysfunction is the second most common endocrine dysregulation in MAS. However, there are no treatment guidelines for MAS complicated with hyperthyroidism. Notably, no case of MAS complicated with retrosternal goiter and hyperthyroidism has been reported to our knowledge.Case presentationWe report a 27-year-old man with MAS who developed the typical triad of bone fibrous dysplasia, skin pigmentation and hyperthyroidism, complaining of recent fast-growing neck mass and difficulty in breathing. Hyperthyrodism was under control by Thiamazole, and computed tomography showed an enlarged thyroid extending retrosternally. We performed a total thyroidectomy on the patient. At the 1-year follow-up, the patient's dyspnea, hyperthyroidism, and bone pain were all significantly alleviated.ReviewWe searched the literature for previous case reports concerning MAS patients complicated with thyroid dysregulation. A total of 17 articles and 22 patients were identified to form our database. Among them, 9 studies clearly mentioned surgical intervention in 11 patients, and prognoses were also reported. Surgery was the most common intervention chosen and indicated a satisfactory prognosis.ConclusionWe report a rare case of MAS patient complicated with retrosternal goiter and hyperthyroidism. Our review provides an overview of MAS cases requiring interventions on thyroid function, and total thyroidectomy should be a proper treatment for these patients.
First study on the outcomes of biliopancreatic diversion with duodenal switch in Chinese patients with obesity
Authors: Wang Lun , Zhang Zheng , Wang Zeyu , Jiang Tao 
Published: January 2023

BackgroundBiliopancreatic diversion with duodenal switch (BPD-DS) is a bariatric procedure used in the treatment of obesity and related metabolic disorders. However, to date, the data on BPD-DS among Chinese patients with obesity is completely lacking.ObjectiveThis is the first study to evaluate the safety and efficacy of BPD-DS in the treatment of Chinese patients with obesity.MethodsData from 12 patients undergoing BPD-DS between September 2019 and March 2020 were analyzed retrospectively to evaluate complications, weight loss, comorbidity resolution, and nutritional status.ResultsAll patients completed the 1-year follow-up. There was no conversion to laparotomy or death. Mean operative time was 257.08 ± 29.27 min. The median length of stay was 7 days (ranging from 4–38 days). Complications occurred in three patients. The 1-year body mass index was 25.13 ± 4.71 kg/m2 with a mean excess weight loss of 100.11 ± 33.29% and a mean total weight loss of 43.22 ± 7.71%. Remission was achieved in 100% (7/7 cases) for type 2 diabetes, in 83.3% (10/12 cases) for hypertension, and in 62.5% (5/8 cases) for hyperuricemia. At 1 year after BPD-DS, the prevalence of albumin deficiency was 16.7%, for iron deficiency was 16.7%, and for zinc deficiency was 50%. There were 8.3% of the patients who were anemic. High deficiency rates for vitamins were presented mainly in vitamin A and vitamin E: vitamin A in 58.3% of the patients and vitamin E in 50% of the patients. The prevalence of asymptomatic gallstones increased significantly from 0% preoperatively to 41.7% postoperatively.ConclusionBPD-DS had excellent weight loss and resolution of comorbidities among Chinese patients with obesity. However, high rates of nutritional deficiencies and complications were found after BPD-DS, especially for vitamin A and vitamin E.
Establish a new parameter “horizontal view-axial angle” and explore its role in the treatment of atlantoaxial instability diseases
Authors: Huang Hongxiang , Sheng Minfeng , Zeng Guangliang , Sun Chao , Li Rujun 
Published: January 2023

ObjectiveThe objective of the study is to establish a new parameter that can be clearly measured on x-ray images to complement the description of the sagittal alignment of the craniocervical junction. The authors anticipate that this new parameter will enhance surgeons' understanding of the sagittal alignment of the craniocervical junction and play a positive role in the guidance of intraoperative reduction and in the evaluation of postoperative outcomes of patients with atlantoaxial instability.MethodsFrom November 2018 to June 2020, a total of 159 asymptomatic subjects who underwent frontal and lateral cervical x-ray examination in the Second Affiliated Hospital of Soochow University were included in the study. Age, gender, previous spinal trauma, and disease history of each subject were recorded. After screening, 127 effective samples were finally obtained. When taking lateral cervical radiographs, all subjects placed their neck in a neutral position and looked straight ahead with both eyes. On the obtained lateral x-ray images, a straight line was drawn from the radix to the anterior clinoid process; another line was made along the posterior edge of the C2 vertebral body; and the angle between the two lines was measured, which was defined as the “horizontal view-axial angle.” The angle formed by the tangent of the posterior edge of the C2 vertebra and C7 vertebral body is the “C2–C7 angle,” which was used to describe the curvature of the lower cervical vertebra. The normal range of horizontal view-axial angle and its relationship with C2–7 angle were evaluated.ResultsThe average C2–C7 angle of male subjects was (14.0° ± 7.4°), while that of female subjects was (11.09° ± 7.36°). The average horizontal view-axial angle of male subjects was (92.79° ± 4.52°), and that of female subjects was (94.29° ± 4.50°). Pearson correlation test showed that there was a significant negative correlation between horizontal view-axis angle and C2–C7 angle.ConclusionsFor patients with atlantoaxial instability diseases, the horizontal view-axis angle is expected to be a sagittal parameter to guide the intraoperative reduction and evaluate postoperative outcomes.
Development and validation of a diagnostic model for differentiating tuberculous spondylitis from brucellar spondylitis using machine learning: A retrospective cohort study
Authors: Yasin Parhat , Mardan Muradil , Xu Tao , Cai Xiaoyu , Abulizi Yakefu , Wang Ting , Sheng Weibin , Mamat Mardan 
Published: January 2023

BackgroundTuberculous spondylitis (TS) and brucellar spondylitis (BS) are commonly observed in spinal infectious diseases, which are initially caused by bacteremia. BS is easily misdiagnosed as TS, especially in underdeveloped regions of northwestern China with less sensitive medical equipment. Nevertheless, a rapid and reliable diagnostic tool remains to be developed and a clinical diagnostic model to differentiate TS and BS using machine learning algorithms is of great significance.MethodsA total of 410 patients were included in this study. Independent factors to predict TS were selected by using the least absolute shrinkage and selection operator (LASSO) regression model, permutation feature importance, and multivariate logistic regression analysis. A TS risk prediction model was developed with six different machine learning algorithms. We used several metrics to evaluate the accuracy, calibration capability, and predictability of these models. The performance of the model with the best predictability was further verified with the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the calibration curve. The clinical performance of the final model was evaluated by decision curve analysis.ResultsSix variables were incorporated in the final model, namely, pain severity, CRP, x-ray intervertebral disc height loss, x-ray endplate sclerosis, CT vertebral destruction, and MRI paravertebral abscess. The analysis of appraising six models revealed that the logistic regression model developed in the current study outperformed other methods in terms of sensitivity (0.88 ± 0.07) and accuracy (0.79 ± 0.07). The AUC of the logistic regression model predicting TS was 0.86 (95% CI, 0.81–0.90) in the training set and 0.86 (95% CI, 0.78–0.92) in the validation set. The decision curve analysis indicated that the logistic regression model displayed a higher clinical efficiency in the differential diagnosis.ConclusionsThe logistic regression model developed in this study outperformed other methods. The logistic regression model demonstrated by a calculator exerts good discrimination and calibration capability and could be applicable in differentiating TS from BS in primary health care diagnosis.
Clinical application of Kirschner wires combined with 5-Ethibond fixation for patella fractures
Authors: Liang Yuan , Hu Jinlong , Zhang Pei , Zhang Jiale , Yang Lixun , Zhang Wendong , Chen Jiaxin , He Jinshan , Fang Yongchao , Zhou Yuelai , Chen Pengtao , Wang Jingcheng 
Published: January 2023

BackgroundPatella fractures that require surgery are conventionally treated using Kirschner wires (K-wires) and stainless steel wires. In recent years, the nonabsorbable polyester has been reported to have excellent outcomes clinically. Therefore, the goal of our study was to evaluate the effects of Kirschner wires combined with 5-Ethibond on treating patellar fractures.MethodsFrom July 2018 to January 2022, 22 patella fracture patients were treated with Kirschner wires combined with 5-Ethibond. Radiographs of the knees were used to evaluate fracture healing and hardware complications. The clinical results were evaluated through the functional score, knee joint range of motion (ROM), and Bostman patella fracture functional score.ResultsThe average age of patients was 57.4 ± 11.9 (range 33–74) years. The mean follow-up time was 15.2 ± 7.6 (range 4–36) months. The mean operation time was 56.8 ± 8.7 (range 45–80) min. The entire patients had bony union at an average of 10.5 ± 1.9 (range 8–14) weeks. At the final follow-up, the mean range of postoperative ROM was 123.4° ± 14.6° (range 95°–140°), and the functional score was 28.7 ± 1.2 (range 26–30) points. No patient exhibited internal fixation failure, and no symptomatic implants or skin complications were recorded.ConclusionsThe fixation approach using K-wires combined with 5-Ethibond has a lower complication rate and delivers superior clinical results. This research reveals that such technology is a safe and prospective substitute for conventional metal fixation approaches.
Essential Oil Composition Analysis of Cymbopogon Species from Eastern Nepal by GC-MS and Chiral GC-MS, and Antimicrobial Activity of Some Major Compounds
Authors: Dangol Sabita , Poudel Darbin Kumar , Ojha Pawan Kumar , Maharjan Salina , Poudel Ambika , Satyal Rakesh , Rokaya Anil , Timsina Sujan , Dosoky Noura S. , Satyal Prabodh , Setzer William N. 
Published: January 2023

Cymbopogon species essential oil (EO) carries significant importance in pharmaceuticals, aromatherapy, food, etc. The chemical compositions of Cymbopogon spp. Viz. Cymbopogon winterianus (citronella) Cymbopogon citratus (lemongrass), and Cymbopogon martini (palmarosa) were analyzed by gas chromatography–mass spectrometry (GC-MS), enantiomeric distribution by chiral GC-MS, and antimicrobial activities of some selected pure major compound and root and leaves EOs of citronella. The EO of leaves of Cymbopogon spp. showed comparatively higher yield than roots or other parts. Contrary to citral (neral and geranial) being a predominant compound of Cymbopogon spp., α-elemol (53.1%), α-elemol (29.5%), geraniol (37.1%), and citral (90.4%) were detected as major compounds of the root, root hair with stalk, leaf, and root stalk with shoot of citronella EO, respectively. Palmarosa leaves’ EO contains neral (36.1%) and geranial (53.1) as the major compounds. In the roots of palmarosa EO, the prime components were α-elemol (31.5%), geranial (25.0%), and neral (16.6%). Similarly, lemongrass leaves’ EO contains geraniol (76.6%) and geranyl acetate (15.2%) as major compounds, while the root EO contains a higher amount of geraniol (87.9%) and lower amount of geranyl acetate (4.4%). This study reports for the first time chiral terpenoids from Cymbopogon spp. EOs. Chiral GC-MS gave specific enantiomeric distributions of nine, six, and five chiral terpenoids in the root, root stalk with a shoot, and leaves of citronella EOs, respectively. Likewise, four and three chiral terpenoids in the root and leaves of lemongrass oil followed by two chiral terpenoids in the leaves and root of palmarosa EOs each. Additionally, the root and leaves’ EOs of citronella exhibit noticeable activity on bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes and fungus such as Candida albicans, Microsporum canis, and Trichophyton mentagrophytes. So, geranial-, neral-, geraniol-, and citronellal-rich EOs can be used as an alternative antimicrobial agent.
EVALUASI KINERJA RUAS JALAN DAN SIMPANG TIDAK BERSINYAL DENGAN FASILITAS PUTAR BALIK (U-TURN) STUDI KASUS JALAN SRIWIJAYA DI KOTA MATARAM
Authors: ROHANI ROHANI , HASYIM HASYIM , HIDAYTULLAH MUHAMAD DILAN 
Published: January 2023

Along with the increasing population and increasing development in all sectors in Mataram City every year, resulting in an increase in the volume of vehicles which often causes potential traffic conflicts. This condition results in disturbances for motorists in the flow of vehicles on the u-turn facility so that it affects performance on the road. One of the roads in the city of Mataram that is the choice in the travel route for the community is Jalan Sriwijaya. It is necessary to review the performance of roads with median openings, especially on unsignalized roads and intersections.The method used in this study is the calculation of urban road performance using MKJI 1997. Data from the location of median openings on unsignaled roads and intersections were collected through a field survey and then calculated the average traffic flow, average speed, average turning time average, capacity, degree of saturation, and level of road service. The results of the analysis show that the average traffic flow that occurs on the Sriwijaya road is 864.73 pcu/hour with a capacity of 2737.15 pcu/hour and the degree of saturation (DS) is 0.316 so that it is classified as a service level "B", while the average traffic flow at the unsignalized intersection is 2441.77 pcu/hour with a capacity of 4199.91 pcu/hour and a degree of saturation (DS) value of 0.581 so that it is classified in the "C" service level. The average turning time on roads is 8.04 seconds and at unsignalized intersections 6.94 seconds.
ANALISIS PENGARUH HARGA DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN KERUPUK RUMPUT LAUT UD. HARKAT MAKMUR
Authors: DETHAN STEVANY HANALYNA , MEIKAPASA NI WAYAN PUTU , CATHARINA THERESIA SUZANNA 
Published: January 2023

This study aimed to find out the price and promotions singinificant effect on purchasing decision kerupuk rumput laut UD. Harkat Makmur in partial or simultan. This associative research study was conducted. The study employed a non probability sampling with insidental sampling technique by involving 50 respondents as the samples. Data analysis method in this study use multiple linier regression analysis. The result of the study show price and promotions have significant effect on purchasing decision kerupuk rumput laut UD. Harkat Makmur in partial or simultan.
ANALISIS KOMPARATIF MODAL DAN PENDAPATAN PEDAGANG PASAR KEDIRI TABANAN SEBELUM DAN SELAMA PANDEMI COVID-19
Authors: SARJANA I WAYAN MULA , TERIMAJAYA I WAYAN , PUTRA ANAK AGUNG GEDE 
Published: January 2023

The traditional market is the center of the economy where the lower middle class looks for needs and income. The purpose of this study was to determine the capital gap between traders in the Kediri Tabanan market before and during the Covid-19 pandemic, as well as to determine the income gap between traders in the Kediri Tabanan market before and during the Covid-19 pandemic.The method of determining the sample uses a simple random sampling technique, where the number of samples to be taken is 88 traders at the Kediri Tabanan Market. The data analysis technique used was paired t-test.Based on the results of SPSS calculations, the following results were obtained: (1) There were differences in the capital of traders at the Kediri Tabanan Market before and during the Covid-19 pandemic, where the value of t count was greater than t table or 23,018>1,988 and the significance value was less than 5% or 0.000 < 0.05. (2) There is a difference in income for traders at the Kediri Tabanan Market before and during the Covid-19 pandemic, where the value of t count is greater than t table or 21,881 > 1,988 and the significance value is less than 5% or 0.000 < 0.05
Penerapan sikap sopan santun kepada siswa di mda al-idris
Authors: Najwa Nurfajriah  , Nursifa Faujiah  , Imam Tabroni  
Published: January 2023

Sebagai lembaga yang mengajarkan mengenai pendidikan islam tentunya, MDA AL-IDRIS ini juga sangat menjungjung tinggi nilai sopan santun. Sikap sopan santun itu sendiri merupakan unsur penting dalam kehidupan Sehari-hari baik di lingkungan sekolah maupun masyarakat. Karena, jika kita menerapkan sikap sopan santun maka kita akan di hargai dan disenangi dimanapun kita berada. Namun sayangnya, di MDA AL-IDRIS ini tidak sedikit siswa yang menyepelekan sikap sopan santun dalam kesehariannya. Oleh karena itu, Penelitian ini dilakukan untuk mengkaji tentang pentingnya menerapkan sikap sopan santun di MDA AL-IDRIS. Metode yang dilakukan dalam penelitian ini ialah menggunakan metode lapangan (field research). Karena dengan menggunakan metode lapangan kita dapat mengetahui lebih banyak mengenai permasalahan-permasalahan yang terjadi dan menemukan cara yang tepat untuk mengatasi permasalahan-permasalahan tersebut. Jika kita mengedepankan sikap sopan santun, kita dapat merasa damai karena jauh dari perselisihan dan memberikan keyakinan terhadap diri sendiri di setiap situasi serta menciptakan suasana yang baik.
ANALISIS KETIDAKTERTARIKAN PENGUNJUNG DATANG KE MUSEUM PERJUANGAN KOTA BOGOR
Authors: Brigitta Trianita  , Dewantara Yudhiet Fajar 
Published: January 2023

Museum merupakan tempat kumpulan benda-benda sejarah sebagai bukti yang harus diketahui oleh masyarakat, keaslian koleksi dan diorama yang dimiliki museum belum mampu untuk menarik wisatawan untuk datang ke Museum Perjuangan Bogor. Bangunannya yang usang serta kurangnya keunikan penyampaian serta penataan koleksi menjadi beberapa alasanya. Tujuan penelitian ini menganalisa ketidaktertarikan masyarakat untuk berkunjung ke Museum Perjuangan di Kota Bogor. Penelitian ini menggunakan metode kualitatif. Hasil penelitian yang telah dilakukan Museum Perjuangan kota Bogor masih sepi pengunjung diakibatkan oleh kurangnya minat masyarakat terhadap sejarah dan kalah saingnya museum perjuangan dengan museum lain yang ada di kota Bogor. Pada museum sendiri tidak banyak aktivitas wisata yang bisa dilakukan hanya melihat koleksi saja. Apabila dilihat dari fasilitas wisatanya, museum ini terletak di pusat kota, akses dan transportasinya mudah, dekat dengan rumah penduduk, sekolah, mall PGB, toko-toko, dan tempat makan yang tersedia disekitar museum. Kondisi bangunan museum pun sangat memprihatinkan. Bantuan Pemerintah juga belum ada untuk museum ini sehingga pengembangan museum pun terhambat karena dana serta kegiatan promosi sangat kurang. Saran yang dapat diberikan adalah pemerintah dan pihak museum harus bekerjasama melakukan pengembangan dan perbaikan gedung museum, aktivitas wisata, pengelolaan koleksi, promosi, memberikan perhatian secara langsung maupun tidak langsung serta bantuan dana untuk pengembangan museum.
Characterization of dislocation of halide vapor phase epitaxial (001) β-Ga2O3 by ultrahigh sensitive emission microscopy and synchrotron X-ray topography and its influence on Schottky barrier diodes
Authors: Sdoeung Sayleap , Sasaki Kohei , Kawasaki Katsumi , Hirabayashi Jun , Kuramata Akito , Kasu Makoto 
Published: January 2023

Abstract
This study elucidates the dislocation responsible for the leakage current in a halide vapor phase epitaxial (001) β-Ga2O3 Schottky barrier diode. A high reverse leakage current of −0.98 μA was observed at −100 V as an emission pattern via ultrahigh-sensitive emission microscopy. This was attributed to the presence of dislocation. Moreover, the Burgers vector of this dislocation was determined to be ⫽ 〈1

3
¯

2〉 from the g·b invisibility criteria via synchrotron X-ray topography observation. This dislocation was speculated to be induced by the relaxation of the strain field surrounding the void and subsequently propagated to the surface. Cross-sectional scanning transmission electron microscopy revealed multiple threading dislocations along the (100) plane.
Optical modeling and active layer design of MASnI3 perovskite photovoltaics using finite-difference time-domain simulation: from the sun to indoor light
Authors: Seo Kyeong-Ho , Biswas Swarup , Jeon Sang-Hwa , Kim Hyeok , Bae Jin-Hyuk 
Published: January 2023

Abstract
We investigated the optoelectronic effect of MASnI3 perovskite-based photovoltaics by designing an active layer using the finite-difference time-domain simulation. AM 1.5 G was chosen as the solar light source, set to provide the 400–900 nm wavelength region. As an active layer design method, we controlled the active layer thickness from 20 to 200 nm with a 20 nm step. As the active layer thickness became thicker, J
sc rose sharply and became saturated, and when it was 200 nm, J
sc was highest at 25.64 mA cm−2. Furthermore, we solved the electric field intensity distribution for each wavelength of light according to the active layer thickness. Finally, by calculating J
sc according to the active layer thickness and generation rate of the optimal device under indoor light sources, we were able to extend our research to indoor applications.
Design and fabrication results of Z-gate layout MOSFETs for radiation hardness integrated circuit
Authors: Kuroki Kaito , Kimura Arisa , Hirakawa Kenji , Iwase Masayuki , Ogasawara Munehiro , Yoda Takashi , Ishihara Noboru , Ito Hiroyuki 
Published: January 2023

Abstract
A Z-gate layout MOSFET (ZLT) is expected to reduce the total ionizing dose effects which occur in the shallow trench isolation layer made of oxide. To verify the ZLT’s merit, the ZLT was designed and fabricated with the 0.18 μm standard CMOS technology. The ZLT was irradiated with 60Co γ-rays up to 10 Mrad, and its I–V characteristic fluctuation was compared with that of a standard straight gate layout MOSFET (SLT). As a result, it was confirmed that the Z-gate can suppress off-current fluctuations by 1/5, on-current fluctuations by 1/2 and threshold voltage fluctuations by 1/6 compared with the SLT. Since the size penalty of the ZLT is small, it is possible to improve the radiation hardness of the CMOS LSI circuit by just replacing SLTs with ZLTs.