bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production of extracellular lipase by Enterococcus faecium E68 with olive oil waste as substrate
Authors: KIVANC Merih , Acu Esra 
Published: June 2023

With green technologies, the damages caused by agro-technological wastes to the environment are eliminated. In our study, it was aimed both to prevent the harm of olive oil waste to the environment and to produce lipase enzyme, which is an important biotechnological product.. E. faecium E68 obtained from milk and dairy products was used in the production of lipase enzyme. E. faecium E68 was developed in lipase production medium containing 10% olive waste, pH6.5, at 37oC with 120 rpm agitation for 48 hours. The effect of temperature, pH metal ion, surfactant and NaCl was also determined.
The molecular weight of the partially purified extracellular lipase enzyme was estimated to be around 19-20 kDa by SDS-PAGE. The optimum temperature was 45°C, while the enzyme exhibited appreciable thermostability retaining of activity at 55°C for 48h. The lipase was most active in the pH range of 3-11 with an optimum activity at pH 10. 1mM, Ca 2+, Mn2+, Cu2+, Ni2+, Zn2+, Mg2+ and K+ ions modulated the activity of the enzyme but inhibited by Hg2+, SDS and Triton X-100. The enzyme is halophilic and 25% NaCl salt increased the activity.
Olive oil waste may be the preferred substrate for lipase production.
Screening of Natural High-producing NMN strains and Microbial Synthesis of NMN by Nampt
Authors: Li Chao , Long Zouguo , Zhang Haichao , Lin Yuhui , Zhao Liqing 
Published: June 2023

Nicotinamide mononucleotide (NMN) is an endogenous substance in humans with high safety and thermal stability, and its application in cosmetics, medical health, and functional foods has received widespread attention. However, the synthesis process of NMN has problems such as high cost, time-consuming and low yield, which limits the large-scale industrial application of NMN to a certain extent. Nicotinamide phosphate ribose transferase (Nampt) is a critical enzyme in a technical route in the biological synthesis of NMN, which can catalyze the synthesis of NMN by Nicotinamide (NAM) and Phosphoribosyl pyrophosphate (PRPP). Screening and expression of a Nampt with excellent enzymatic properties and stability is the key to the synthesis of NMN by this method. At present, the main problems in the technical route of NMN production by Nampt are that the catalytic activity of Nampt is low. And the source of Nampt is small and limited, so we isolated the microorganism with high NMN production, Enterobacter chengduensis 2021T4.7, and optimized its fermentation conditions. The yield of NMN is up to 67.66 μM. In addition, we synthesized Nampt and constructed related recombinant high-yield engineering bacteria. We semi-rationally designed the Nampt structure derived from mice and obtained mutant mNampt-V365L with NMN yields as high as 135.99 μM increased by 62% compared with wild type. Here, we screened high-yield NMN natural strains, and obtained high-yield strains through the semi-rational design optimization of Nampt enzyme, which provided new chassis microorganisms and new ideas for the conversion rate of NMN.
Capillary force method to improve the green density of binder jet additive manufacturing
Authors: Soylemez Emrecan 
Published: June 2023

This study investigates the impact of capillary adhesion force on the green part density in metal powder binder jetting 3D printing. Gas atomized Co-Cr-Mo, SS316L, and pure Cu powders were used to print various samples. The printed samples were then treated with water, 1-Hexanol, and n-Amyl alcohol vapor for 24 hours to nucleate capillary bridges between particles and shrink samples uniformly. The volume change was calculated for each sample, and up to –3.1 % volume change was observed. The proposed method can be used to improve green part densities directly on printed parts before sintering.
A wholelife cost and carbon perspective of alternatives to septic tanks utilising nature-based solutions
Authors: Brown Gareth C. , MacAdam Jitka , Dotro Gabriela , Jefferson Bruce 
Published: June 2023

Abstract
Septic tank systems (STSs) are widely utilised flowsheets for decentralised wastewater treatment in the UK. With a growing consensus that STSs have a sizeable detrimental impact on the environment, there is a need for rural flowsheets with improved treatment capabilities. This study examines the lifetime cost and carbon emissions of using an enhanced septic tank nature-based solution (EST-NBS) to improve STS compared to a package treatment system (submerged aerated filter (SAF)). The wholelife cost (WLC) of the flowsheets and Scope 2 cradle-to-grave lifetime carbon emissions (LCEs) of the flowsheets were assessed. The EST-NBS flowsheets represent a lower cost improved treatment system than SAFs at population equivalents (PEs) from 5 to 1,000. An STS averages an LCE of over 4,000 kg CO2eq PE−1, with all other considered flowsheets having lower emissions. The EST-NBS flowsheets had lower carbon emissions than SAFs. Even at low populations upgrading from an STS to an EST-NBS is a competitive abatement strategy, with costs of £260 tCO2eq−1 emissions avoided, at 1,000 PE an NBS flowsheet has an abatement cost of –£17 tCO2eq−1. This shows the potential of using NBS flowsheets in rural wastewater treatment providing both a carbon and cost incentive against traditional designs.
Rotary gate discharge determination for inclusive data from free to submerged flow conditions using ENN, ENN–GA, and SVM–SA
Authors: Marashi Ava , Kouchakzadeh Salah , Yonesi Hojjat Allah 
Published: June 2023

Abstract

This study aims at evaluating the performance of the Elman Neural Network (ENN), Elman Neural Network-Genetic Algorithm (ENN–GA), and Support Vector Machine-simulated annealing (SVM–SA) in determining the discharge of a newly proposed rotary gate for the inclusive data range from free flow to highly submerged conditions. For individual free and submerged flows, the models performed as well as that of the traditional relationships. However, the superiority of the intelligent models comes when dealing with the inclusive data set of both flow conditions, where no deterministic approach is available for discharge evaluation prior to specifying the threshold condition. In such complex flow conditions, the ENN–GA hybrid model with a proper structure determined the discharge with rather a high accuracy, i.e., SE of 6.12%. Also, in defining the threshold state, the ENN and ENN–GA models achieved superior results compared to the currently available relationship, i.e., it accurately recognized the threshold condition in almost 100% of the cases while the traditional relationship results were limited to 93% of the cases. Such accuracy of the employed model in assessing the discharge of the structure and its high ability in recognizing the flow state could be of great advantage for irrigation network structure automation.
Global prevalence and genotype distribution of Microsporidia spp. in various consumables: a systematic review and meta-analysis
Authors: Rezaeian Sanaz , Taghipour Ali , Bahadory Saeed , Mogharab Vahid , Abdoli Amir 
Published: June 2023

Abstract
Water and food sources play a major role in the distribution and transfer of microsporidia infection to animals and humans. So, this systematic review and meta-analysis aimed to assess the status and genetic diversity of microsporidia infection in water, vegetables, fruits, milk, cheese, and meat. The standard protocol of Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines was followed. Scopus, PubMed, Web of Science, and Google Scholar were searched from 1 January 2000 and 1 February 2023. The point estimates and 95% confidence intervals (CIs) were calculated using a random-effects model. Of the 1,308 retrieved studies, 35 articles were included in the final meta-analysis. The pooled prevalence of microsporidia infection in mixed water, mixed fruits, mixed vegetables, and milk was 43.3% (95% CI, 33–54.2%; I2, 94.86%), 35.8% (95% CI, 5.3–84.8%; I2, 0), 12% (95% CI, 4.9–26.6%; I2, 96.43%), and 5.8% (95% CI, 2.7–12%; I2, 83.72%), respectively. Considering the genotypes, microsporidia with genotype D in water sources and genotype CD6 in vegetables/fruits were the highest reported genotypes. Given the relatively high prevalence of microsporidiosis (especially in water sources), designing strategies for control, and prevention of microsporidia infection in these sources should be recommended.
Biodegradation of di(2-ethylhexyl) phthalate by a new bacterial consortium
Authors: Kou Liangwei , Chen Hanyu , Zhang Xueqi , Liu Shaoqin , Zhang Baozhong , Zhu Huina 
Published: June 2023

Abstract

Di(2-ethylhexyl) phthalate (DEHP) with continuous high concentration was used as the sole carbon and energy source to isolate a new bacterial consortium (K1) from agricultural soil covered with plastic film for a long time. Unclassified Comamonadaceae, Achromobacter, and Pseudomonas in K1 were identified as major genera of the consortium by high-throughput sequencing, and unclassified Commanadaceae was first reported to be related to DEHP degradation. Response surface method (RSM) showed that the optimum conditions for K1 to degrade DEHP were 31.4 °C, pH 7.3, and a concentration of 420 mg L−1. K1 maintains normal cell viability and stable DEHP degradation efficiency in the range of 10–3000 mg L−1 DEHP concentration, which is superior to existing research. The biodegradation of DEHP followed first-order kinetics when the initial concentration of DEHP was between 100 and 3,000 mg L−1. GC-MS analysis of different treatment groups showed that DEHP was degraded by the consortium group through the de-esterification pathway, and treatment effect was significantly better than that of the single bacteria treatment group. The subsequent substrate utilization experiment further confirmed that K1 could quickly mineralize DEHP. In addition, K1 has high degradation capacity for the most common phthalate acid esters in the environment.
The modern view on the epiglottitis treatment
Authors: Kononov O.Ye. , Trishchynska M.A. 
Published: June 2023

Primary health care is defined as “primary contact, continuous, comprehensive, and coordinated care provided to the population without differentiation by gender, disease, or organ system”. Versatility, as part of medical school curricula, is intrinsically important for those pursuing careers with a significant primary care component, such as family medicine, emergency medicine, therapy, and pediatrics. Otolaryngology is an important specialty related to family medicine, pediatrics, and general practice. Otolaryngological problems make up a significant part of appeals for primary health care. Approximately 20 to 40 % of adult general practice consultations are related to otolaryngological complaints. The Ukrainian health care reform makes significant adjustments in approaches to the diagnosis and treatment of most diseases. Pathology can be so varied and the scope of practical skills can be limited by doctor’s competence. For diagnosis, a family doctor can use the ISPS-2 international classification, which greatly facilitates and unifies the work of a general practitioner. An epiglottic abscess is usually the final stage of inflammation of the epiglottis (epiglottitis) and surrounding tissues. The etiology of the disease can be of infectious or non-infectious nature. Clinical signs of epiglottitis vary depending on age, severity, and etiology. Without treatment, epiglottitis can progress to life-threatening airway obstruction, so prompt diag­nosis and management of epiglottitis in children is extremely important. The disease must be diagnosed at the early stages of the pathological process, following the patient’s route. It requires deep knowledge of the disease etiopathogenesis, mastering research methods, and using all the possible arsenal of treatment to prevent complications. Coordinated cooperation of medical staff at all stages of providing medical care should be ensured.
Value of the number of injured anatomical parts of the body and surgeries for pain chronicity in patients with gunshot wounds and blast injuries
Authors: Horoshko V.R. 
Published: June 2023

The outcome of pain treatment in patients with wounds at different stages of management is important, because chronic pain is diagnosed in 83.3 % of victims with blast injuries, and in 70 % of people with gunshot wounds. In civilian life, chronic pain occurs in 11–40 % of cases in a similar category of patients. The reasons for such a high frequency of chronicity have not been sufficiently studied. Thus, the study on the influence of the number of injured anatomical parts of the body on the results of pain treatment will play an important role and contribute to improving the latter in this category of patients. One of the factors that can influence pain chronicity is the number of injured anatomical parts of the body.
Types of perception of information by subjects of training in the specialty “Anesthesiology and intensive care”
Authors: Yekhalov V.V. , Kravets O.V. , Sedinkin V.A. , Pylypenko O.V. 
Published: June 2023

Background. Modern literary sources indicate that of the five main channels through which a person receives information (sight, hearing, taste, smell, and tactile sensations), subjects of learning mainly use only three — auditory, visual, and tactile that determine auditory, visual and kinesthetic. Purpose was to determine the types of perception of information by interns and participants of training in the specialty “Anesthesiology and intensive care” to optimize the postgraduate training process. Materials and methods. An anonymous survey of 48 interns and 51 practicing doctors in the specialty “Anesthesiology and intensive care” was conducted using a special questionnaire, followed by interpretation and analysis according to the dominant channels of obtaining information and their combinations. Results. When evaluating the leading (dominant) sensory modalities in the group of intern doctors, a significant advantage of auditory perception among other channels of receiving information was determined. The evaluation of the leading sensory types in the group of training participants who have their own specific work experience in the specialty showed a significant predominance of the kinesthetic informational channel, which is slightly inferior to the auditory sensory type, and only 11.2 % of the respondents account for the visual modality. The involvement of most sensory analyzers and the combination of modalities in the educational process contributes not only to the holistic perception, analysis and assimilation of educational information, but also to the formation of multimodal thinking. Therefore, during the educational process, multimodal technologies should be used, which allow providing educational material in several formats at the same time. Conclusions. 1. Interns mostly demonstrated the dominance of audio-kinesthetic and polymodal types of information acquisition. 2. Anesthesiologists with some practical experience are more inclined to monokinesthetic and audio-kinesthetic information modality. 3. The polymodal type of providing educational information is optimal in postgraduate education of medical workers. 4. The introduction of short-term trainings on mastering practical skills into the educational process creates an optimal combination of ways to obtain educational information and consolidate memory by subjects of training.
Studying the effectiveness of varieties of anticoagulant therapy programs in patients with a severe course of COVID-19 (analysis of own clinical observations)
Authors: Mazur O.M. , Bondar M.V. 
Published: June 2023

Background. Currently, there is no internationally approved protocol for anticoagulant therapy (ACT) in patients with COVID-19 that describes the different types of ACT programs depending on the severity of COVID-19. The objective: to determine optimal ACT programs. Materials and methods. A retrospective ana­lysis of ACT programs was conducted in 268 patients with extremely severe COVID-19 who were treated in the intensive care units. Results. The article presents the results of retrospective analysis of ACT programs in 268 patients with a very severe course of COVID-19 treated in the general intensive care unit in 2021. ACT programs in 162 patients who died because of COVID-19 and in 106 survived patients were studied separately. The total duration of hospital stay was from 9 to 55 days. ACT programs were mostly in line with Euro­pean guidelines/instructions. ACT included a stepwise combination of unfractionated heparin, low-molecular-weight heparins, and oral anticoagulants depending on the clinical course, concomitant pathology, and laboratory parameters. The systemic inflammatory response was characterized by the concentration of C-reactive protein in the blood plasma within the range of 54.7–331.4 mg/l (on average 95.4 ± 73.4 mg/ml), ferritin of 208–2094 μg/l (on average 947.16 ± 872.00 μg/l), interleukin-6 of 33.9–507.4 pg/ml (on average 152.60 ± 201.15 pg/ml). The level of D-dimer in blood plasma ranged from 3.74 to 82.0 μg/ml (on average 8.200 ± 3.525 μg/ml). Platelet content in peripheral blood ranged from 372 × 109/l to 72 × 109/l. Conclusions. The optimal ACT program in patients with severe and extremely severe COVID-19 is a program of sequential change of anticoagulant drugs to enhance their anticoagulant effect, which can be controlled by laboratory tests.
PENGARUH TECHNOLOGY ACCEPTANCE MODEL TERHADAP KEPUTUSAN MUZAKKI MEMBAYAR ZAKAT MELALUI FINTECH GOPAY (STUDI PADA MUZAKKI BAZNAS DKI JAKARTA)
Authors: Ichwan Afiful , Abdul Ghofur Ruslan 
Published: June 2023

Indonesia is one of the countries with the most Muslim population. but in Indonesia zakat so far the realization of its acceptance is far from the existing potential. Baznas as a government institution authorized to carry out the processing and distribution of Zakat funds continues to increase Zakat receipts by working together to bring innovative Zakat facilities through fintech Gopay, the results of this innovation with fintech Gopay have managed to help collect donations of 63 billion. By using the Technology Acceptance Model. the authors analyze and understand the factors in influencing the acceptance of use through technology. The formulation of the problem how the influence of the Technology Acceptance Model on the decision to pay Zakat through Fintech Gopay? The results of the study concluded that the Technology Acceptance Model (perceived usefulness and perceived ease of use) partially and simultaneously influences the decision to pay Zakat through Fintech Gopay
Keywords: Technology Acceptance Model, Zakat, Gopay fintech, Decision.
ANALISIS PERAN SUKUK SEBAGAI INSTRUMEN NEGARA DALAM MENGENTASKAN KEMISKINAN DI INDONESIA
Authors: Adinugroho Mukhtar 
Published: June 2023

Today the capital market is one of the instruments that play an important role in the economies of both developed and developing countries. For developing countries like Indonesia, the capital market is an economic potential capable of offering solutions to capital problems that are often faced in the context of national development. Especially when efforts to obtain additional capital through loans are felt to be increasingly unprofitable. Likewise with the Islamic capital market, although it is still new when compared to other Islamic financial instruments, the development of the Islamic capital market in Indonesia is considered quite good. One of the Islamic financial instruments that are important financing for the state budget is Sukuk. Domestically, Sukuk has grown quite rapidly, although the proportion is still relatively small compared to conventional markets. This will be able to support the development of the Islamic capital market in Indonesia, especially if it is able to seize the opportunities that exist. One of these opportunities is that waqf assets are widely available in various regions in Indonesia and many of which have not been exploited productively. The dual integration between Sukuk and waqf in Sukuk Al Intifa'a is expected to be able to create a financial instrument that can boost economic development and as an alternative in efforts to alleviate poverty in Indonesia.
Keywords: Sukuk, Waqaf, Poverty, Sharia Capital Market
ANALISIS DETERMINAN RASIO PEMBIAYAAN DAN BIAYA OPERASIONAL TERHADAP PROFITABILITAS PADA BANK JABAR BANTEN SYARIAH PERIODE 2017-2020
Authors: Zakiah Nurlaelah , Solehah Ilis 
Published: June 2023

The purpose of this study was to analyze the level of the financing ratio or the Financing to Deposit Ratio (FDR) and operating costs (BOPO) to the Return on Assets (ROA) that occurred in BJBS for the 2017-2020 period. The research method used is in the form of quantitative analysis. The data source is generated from the Quarterly Reports published by the BJBS official website starting from the period 2017 to 2020. The results show that partially the FDR ratio shows a value of 0.620 > 0.05 meaning that there is no significant effect between FDR on ROA, while the BOPO ratio shows a value of 0.000 <0.05 means that there is a significant effect between BOPO on ROA. Simultaneously, the resulting value of 0.000 <0.05 means that there is a significant effect between FDR and BOPO on ROA. In that case, the R-Square value obtained is 0.820 or equivalent to 82% which indicates that the effect of FDR and BOPO on ROA is 82% while the rest (100% - 82% = 18%) is influenced by other variables outside of the research discussion.
Keywords; Financing to Deposit Ratio, Operational Costs, Return on Assets.
ISLAMIC FINANCIAL PLANNING: KONSEP LITERASI KEUANGAN SYARIAH SEBAGAI ALTERNATIF PERENCANAAN FINANSIAL BAGI MAHASISWA
Authors: Parhan Muhamad , Taufik Rakhmat Anwar Taufik Rakhmat , Abyan Ashshidqi Muhammad , Sylvia Dewi Lia , Bunga Edelweis Sherly Lorenza , Regina Prayoga Fitri 
Published: June 2023

In this modern era, financial literacy is one of the most important substance. Financial literacy is an alternative strategy to building economic growth and financial stability to survive and face the diversity of services available. The concept of Islamic finance is managing finances better, and being smart for choosing halal and profitable investments. The role of students regarding the level of sharia literacy is needed to disseminate it to the community which will ultimately be implemented by the community itself. Improving financial literacy must be a program at every university for all students because the role of financial regulation, according to sharia is very important for a good level financial literacy. This study uses a qualitative research method with a descriptive approach. The technique used to collect data in this research is a questionnaire. The population of this research is Indonesian Muslim's students by using purposive sampling technique. The results show that most Indonesian Muslim students have some problems in managing finances. This happens because of the lack of socialization related to Islamic Financial Planning so that students find it difficult to apply it in everyday life. There needs to be long-term socialization so that students can understand it well.
Keywords; Islamic Financial Literacy; Islamic Financial Planning; Student Finance