bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-ended protection method for hybrid HVDC transmission line based on transient voltage characteristic frequency band
Authors: Shu Hongchun , Wang Shixin , Lei Shunguang 
Published: June 2023

AbstractHybrid high-voltage direct current (HVDC) transmission has the characteristic of long transmission distance, complex corridor environment, and rapid fault evolution of direct current (DC) lines. As high fault current can easily cause irreversible damage to power devices, rapid and reliable line protection and isolation are necessary to improve the security and reliability of hybrid HVDC transmission system. To address such requirement, this paper proposes a single-ended protection method based on transient voltage frequency band characteristics. First, the frequency characteristics of the smoothing reactor, DC filter, and DC line are analyzed, and the characteristic frequency band is defined. A fault criterion is then constructed based on the voltage characteristic frequency band energy, and faulty pole selection is performed according to the fault voltage characteristic frequency band energy ratio. The proposed protection method is verified by simulation, and the results show that it can rapidly and reliably identify internal and external faults, accurately select faulty poles without data communication synchronization, and has good fault-resistance and anti-interference performance.
Extra-long treatment of MDR-TB osteomyelitis of humerus due to neurotoxicity from the 2nd-line drugs: a case report
Authors: Naser Naser , Abdulla Habib , Kadhem Husain 
Published: June 2023

AbstractInfection with tuberculosis (TB) still considered a leading infectious cause of death, osteomyelitis TB rare entity, and being extraspinal MDR-TB make it very rare case; most of experience in treating osteomyelitis TB was derived from pulmonary TB experience, and we present a case of humerus MDR-TB that was treated for 5 years, with several interruption due to side effect and other causes.
Economic impact of reducing treatment gaps in depression
Authors: McCrone Paul , Young Allan H. , Zahn Roland , Eberhard Jonas , Wasserman Danuta , Brambilla Paolo , Balazs Judit , Caldas-de-Almeida Jose , Ulrichsen Andrea , Carli Vladmir , Antunes Ana , Schiena Giandomenico , Quoidbach Vinciane , Boyer Patrice , Strawbridge Rebecca 
Published: June 2023

Abstract

Background
Major depressive disorder (MDD) is highly prevalent across Europe. While evidence-based treatments exist, many people with MDD have their condition undetected and/or untreated. This study aimed to assess the cost-effectiveness of reducing treatment gaps using a modeling approach.

Methods
A decision-tree model covering a 27-month time horizon was used. This followed a care pathway where MDD could be detected or not, and where different forms of treatment could be provided. Expected costs pertaining to Germany, Hungary, Italy, Portugal, Sweden, and the UK were calculated and quality-adjusted life years (QALYs) were estimated. The incremental costs per QALY of reducing detection and treatment gaps were estimated.

Results
The expected costs with a detection gap of 69% and treatment gap of 50% were €1236 in Germany, €476 in Hungary, €1413 in Italy, €938 in Portugal, €2093 in Sweden, and €1496 in the UK. The incremental costs per QALY of reducing the detection gap to 50% ranged from €2429 in Hungary to €10,686 in Sweden. The figures for reducing the treatment gap to 25% ranged from €3146 in Hungary to €13,843 in Sweden.

Conclusions
Reducing detection and treatment gaps, and maintaining current patterns of care, is likely to increase healthcare costs in the short term. However, outcomes are improved, and reducing these gaps to 50 and 25%, respectively, appears to be a cost-effective use of resources.
The State, Local Sociocultural Landscape, and Global Neoliberal Ideology in Vietnam
Authors: Luong Hy V. 
Published: June 2023

AbstractIn the context of accelerating globalization as well as a shifting theoretical landscape in the social sciences and the humanities, this article examines the recent greater attention to the state and global forces, including the global neoliberal ideology, in Asian studies. Empirically, the article examines the resilient roles of family members and relatives in childcare and elderly care in Vietnam and many other parts of East and Southeast Asia, as well as the related trend of relatively low public social expenditures in most East and Southeast Asian societies. The long-standing ideology of familialism, which underlies the pattern of care for the young and elderly in Vietnam and many Asian societies, shapes state policies and exerts an impact on global capitalist operations in Vietnam, notwithstanding the acceleration of globalization, the global neoliberal ideology, and the strong power of the Vietnamese communist party-state. This article suggests that the relation between the local sociocultural landscape, state policies, and global forces involves a dialogic process.
Dynein-2–driven intraciliary retrograde trafficking indirectly requires multiple interactions of IFT54 in the IFT-B complex with the dynein-2 complex
Authors: Hiyamizu Shunya , Qiu Hantian , Tsurumi Yuta , Hamada Yuki , Katoh Yohei , Nakayama Kazuhisa 
Published: June 2023

ABSTRACT
Within cilia, the dynein-2 complex needs to be transported as an anterograde cargo to achieve its role as a motor to drive retrograde trafficking of the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes. We previously showed that interactions of WDR60 and the DYNC2H1–DYNC2LI1 dimer of dynein-2 with multiple IFT-B subunits, including IFT54, are required for the trafficking of dynein-2 as an IFT cargo. However, specific deletion of the IFT54-binding site from WDR60 demonstrated only a minor effect on dynein-2 trafficking and function. We here show that the C-terminal coiled-coil region of IFT54, which participates in its interaction with the DYNC2H1–DYNC2LI1 dimer of dynein-2 and with IFT20 of the IFT-B complex, is essential for IFT-B function, and suggest that the IFT54 middle linker region between the N-terminal WDR60-binding region and the C-terminal coiled-coil is required for ciliary retrograde trafficking, probably by mediating the effective binding of IFT-B to the dynein-2 complex, and thereby ensuring dynein-2 loading onto the anterograde IFT trains. The results presented here agree with the notion predicted from the previous structural models that the dynein-2 loading onto the anterograde IFT train relies on intricate, multivalent interactions between the dynein-2 and IFT-B complexes.
Non-canonical imprinting in the spotlight
Authors: Albert Julien Richard , Greenberg Maxim V. C. 
Published: June 2023

ABSTRACT
Classical genomic imprints are regulated by parent-specific DNA methylation levels inherited from the gametes in mammals. Imprints control gene expression in a parent-of-origin manner and are essential for development. A distinct class of so-called ‘non-canonical’ imprints was recently discovered; these are seemingly regulated by histone methylation and govern parent-specific expression of developmentally important genes, most notably in the placenta. This new class of imprinted genes expands the repertoire of asymmetric parental contributions in mammalian embryogenesis, and raises new questions about the functionality of imprinted gene regulation in mammalian development. In this Spotlight, we summarize the latest findings regarding non-canonical imprinting, mainly from the mouse model, and discuss what we know about the conservation of this phenomenon and how it impacts mammalian development.
Metabolic consequences of sex reversal in two lizard species: a test of the like-genotype and like-phenotype hypotheses
Authors: Wild Kristoffer H. , Roe John H. , Schwanz Lisa , Rodgers Essie , Dissanayake Duminda S. B. , Georges Arthur , Sarre Stephen D. , Noble Daniel W. A. 
Published: June 2023

ABSTRACT
Vertebrate sex is typically determined genetically, but in many ectotherms sex can be determined by genes (genetic sex determination, GSD), temperature (temperature-dependent sex determination, TSD), or interactions between genes and temperature during development. TSD may involve GSD systems with either male or female heterogamety (XX/XY or ZZ/ZW) where temperature overrides chromosomal sex determination to cause a mismatch between genetic sex and phenotypic sex (sex reversal). In these temperature-sensitive lineages, phylogenetic investigations point to recurrent evolutionary shifts between genotypic and temperature-dependent sex determination. These evolutionary transitions in sex determination can occur rapidly if selection favours the reversed sex over the concordant phenotypic sex. To investigate the consequences of sex reversal on offspring phenotypes, we measured two energy-driven traits (metabolism and growth) and 6 month survival in two species of reptile with different patterns of temperature-induced sex reversal. Male sex reversal occurs in Bassiana duperreyi when chromosomal females (female XX) develop male phenotypes (maleSR XX), while female sex reversal occurs in Pogona vitticeps when chromosomal males (male ZZ) develop female phenotypes (femaleSR ZZ). We show metabolism in maleSR XX was like that of male XY; that is, reflective of phenotypic sex and lower than genotypic sex. In contrast, for Pogona vitticeps, femaleSR ZZ metabolism was intermediate between male ZZ and female ZW metabolic rate. For both species, our data indicate that differences in metabolism become more apparent as individuals become larger. Our findings provide some evidence for an energetic advantage from sex reversal in both species but do not exclude energetic processes as a constraint on the distribution of sex reversal in nature.
Evaluating the effect of digital technology on the learning of orthodontic cephalometric measurement
Authors: Yu Xin , Tian Yu , Li Dandan , Sun Wen , Wang Hua , Yuan Siyang , Yan Bin , Wang Lin , Pan Yongchu 
Published: June 2023

Background: This study aimed to evaluate the effect of applying digital technology in orthodontic learning, students' new skills and satisfaction towards it. Methods: In total, 94 undergraduates of stomatology were recruited and randomly allocated to two groups. According to the cross-over design, both groups completed cephalometric measurements through the traditional hand-drawn method and digital technology (the Dolphin software) in different orders. By traditional hand-drawn method, students need to depict the outlines of the craniofacial anatomical structures on the sulfuric transfer paper first, then marked the measurement points and completed the measurement of line spacings and angles. By digital technology, they should mark the points in the software and adjust the automatically generated outlines of the structures and obtained the results. Besides, an online questionnaire was designed to investigate students' attitudes toward the digital technology. Two professional orthodontists were invited as instructors. They measured a lateral cranial radiograph by two methods with one week’s interval, and their intra- and inter-class correlation coefficient were measured. The means of their measurements were set as standards. Results: The inter- and intra-ICC of two instructors surpassed 90%, and there were no significant differences between their measurements, and the measurements by two methods. There were significant differences of students’ measurements (P 1-SNA<0.01, P 1-SNB=0.01 and P 1-L1-NB (mm)<0.01) between the traditional method and digital technology. Besides, the most results of digital technology were closer to the standards than those of traditional method, including five items with statistical significance (P 2-SNB<0.05, P 2-L1-NB (mm)<0.01, P 2-FMA<0.05, P 2-FMIA<0.05, P 2-IMPA<0.01), while three items were the opposite (P 2-SNA<0.05, P 2-ANB (mm)<0.01, P 2-NA-PA<0.01). The questionnaire showed more students preferred digital technology compared with traditional method and 72% of participants mastered 50-80% of cephalometric knowledge after the course.
Mango quality prediction based on near-infrared spectroscopy using multi-predictor local polynomial regression modeling
Authors: Ulya Millatul , Chamidah Nur , Saifudin Toha 
Published: June 2023

Background: pH and total soluble solids (TSS) are important quality parameters of mangoes; they represent the acidity and sweetness of the fruit, respectively. This study predicts the pH and TSS of intact mangoes based on near-infrared (NIR) spectroscopy using multi-predictor local polynomial regression (MLPR) modeling. Herein, the prediction performance of kernel partial least square regression (KPLSR), support vector machine regression (SVMR), and MLPR is compared. Methods: For this purpose, 186 intact mango samples at three different maturity stages are used. Prediction models are built using MLPR, KPLSR, and SVMR based on untreated and treated spectra. The best regression model for predicting pH is MLPR based on Gaussian filter smoothing spectra. Moreover, the TSS value is more accurately predicted using MLPR based on Savitzky–Golay smoothing. Results: The findings reveal that MLPR is highly accurate in estimating the pH and TSS of mangoes, with mean absolute percentage error (MAPE) values less than 10 %. In addition, the MLPR model has the best predictive performance with the lowest Mean Squared error (MSE) and root mean squared error (RMSE) values and the highest R2 value. Conclusions: The use of NIR spectroscopy in combination with multi-predictor local polynomial regression could provide a quick and non-destructive technique for predicting mango quality. Thus, the results of this study help support sustainable production as a sustainable development goal.
Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients
Authors: Rachman Andhika , Rahmaniyah Rizky , Khomeini Andi , Iriani Anggraini 
Published: June 2023

Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. Vitamin D has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, the role of vitamin D in COVID-19 infection remains controversial. This study aimed to analyze the impact of vitamin D deficiency on the clinical outcome of hospitalized COVID-19 patients. Methods: A prospective cohort study was conducted among hospitalized COVID-19 patients at two COVID-19 referral hospitals in Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level in 191 hospitalized COVID-19 patients was 13.6 [IQR=10.98] ng/mL. The serum 25(OH)D levels were significantly lower among COVID-19 patients with vitamin D deficiency who had cardiovascular disease (p-value=0.04), the use of a ventilator (p-value=0.004), more severe COVID-19 cases (p-value=0.047), and mortality (p-value=0.002). Furthermore, serum 25(OH)D levels were significantly different between patients with mild and severe COVID-19 cases (p-value <0.001). Serum 25(OH)D levels in mild and moderate COVID-19 cases were significantly different (p-value=0.002). Lower serum 25(OH)D levels were significantly associated with an increased number of comorbidities (p-value=0.03), the severity of COVID-19 (p-value=0.002), and the use of mechanical ventilation (p-value=0.032). Mortality was found in 7.3% of patients with deficient vitamin D levels. However, patients with either sufficient or insufficient vitamin D levels did not develop mortality. Conclusions: COVID-19 patients with vitamin D deficiency were significantly associated with having cardiovascular disease, mortality, more severe COVID-19 cases, and the used of mechanical ventilation. Lower serum 25(OH)D levels were associated with an increased number of comorbidities, COVID-19 severity, and the use of mechanical-ventilation. Thus, we suggest hospitalized COVID-19 patients to reach a sufficient vitamin D status to improve the clinical outcome of the disease.
In silico screening for potential inhibitors from the phytocompounds of Carica papaya against Zika virus NS5 protein
Authors: Kumaree Kishore Krishna , Anthikapalli Naga Venkata Anusha , Prasansuklab Anchalee 
Published: June 2023

Background: The Zika virus (ZIKV) infection has emerged as a global health threat. The causal reasoning is that Zika infection is linked to the development of microcephaly in newborns and Guillain-Barré syndrome in adults. With no clinically approved antiviral treatment for ZIKV, the need for the development of potential inhibitors against the virus is essential. In this study, we aimed to screen phytochemicals from papaya (Carica papaya L.) against NS5 protein domains of ZIKV. Methods: Approximately 193 phytochemicals from an online database (IMPACT) were subjected for molecular docking using AutoDock Vina against NS5-MTase protein domain (5WXB) and -RdRp domain (5UO4). Results: Our results showed that β-sitosterol, carpaine, violaxanthin, pseudocarpaine, Δ7-avenasterols, Rutin, and cis-β-carotene had the highest binding affinity to both protein domains, with β-sitosterol having the most favorable binding energy. Furthermore, ADME analysis revealed that selected compounds had good pharmacokinetic properties and were nontoxic. Conclusions: Our findings suggest that papaya-derived phytochemicals could be potential candidates for developing antiviral drugs against ZIKV. However, further experimental studies using cell lines and in vivo models are needed to validate their efficacy and safety.
Pesticide exposure and lung cancer risk: A case-control study in Nakhon Sawan, Thailand
Authors: Kangkhetkron Teera , Juntarawijit Chudchawal 
Published: June 2023

Background: Pesticide exposure might increase risk of lung cancer. The purpose of this study was to investigate the association between the historical use of pesticides and lung cancer using a case-control design. Methods: This case-control study compared a lifetime pesticide exposure of 233 lung cancer cases, and 447 healthy neighbours matched for gender, and age (±5 years). Data on demographic, pesticide exposure and other related factors were collected using a face-to-face interview questionnaire. Associations between lung cancer and types of pesticides as well as individual pesticides were analysed using logistic regression adjusted for gender, age, cigarette smoking, occupation, cooking fumes exposure, and exposure to air pollution. Results: It was found that lung cancer was positively associated with the lifetime use of herbicides and insecticides. Compared to people in the non-exposed groups, those in Q3-Q4 days of using herbicides and insecticides had an elevated risk of lung cancer, with odds ratio (OR) between 2.20 (95% confidence interval (CI) 1.24-3.89), and 3.99 (95% CI 1.62-7.11) (p < 0.001). For individual pesticides, those presenting a significant association with lung cancer were dieldrin (OR = 2.56; 95% CI 1.36-4.81), chlorpyrifos (OR = 3.29; 95 % CI 1.93-5.61), and carbofuran (OR = 2.10; 95% CI 1.28-3.42). It was also found, for the first time, carbofuran, glyphosate, and paraquat to be significantly associated with lung cancer. Conclusions: The results reconfirmed the potential effect of pesticides on lung cancer. The study confirmed dieldrin, and chlorpyrifos as risk factors and suggested carbofuran, glyphosate, and paraquat as potential risk factors for the disease. More studies are still required to confirm the results and to identify more individual pesticides that could cause lung cancer. The issues should receive more attention since these chemicals are used widely.
A discussion of early maladaptive schemas in men convicted sexual offenders in Poland.
Authors: Oettingen Justyna , Gierowski Józef Krzysztof , Grabski Bartosz , Micek Agnieszka 
Published: June 2023

Aim of the studyThis study aims to explore differences in the prevalence of early maladaptive schemas (EMS) in convicted sexual offenders (CSO’s) as compared to the general male population (control group).Subject or material and methodsThe study included 102 men incarcerated for sexual offences and 167 men from a non-criminal population. The study used the Polish version of Young’s schema questionnaire – YSQ-S3-PL.ResultsThe results demonstrated a higher degree of EMS severity in CSO except in the ‘impaired limits’ domain where non-criminal individuals scored higher. The individuals who have committed sexual offenses displayed more extensive and severe schemas than non-criminal / non-treated males (including more EMS domains).DiscussionThe study revealed nine early maladaptive schemas characterising the specific mind-set of male sex offender convicts. The results seem to illustrate well the genesis of the formation of a disordered personality as described by J. Young within the schema therapy concept. In the context of the cited studies, these structures – in addition to their important role in the development of psychopathology – appear to contribute to sexual offending.ConclusionsThe conclusion emerging from the findings is that EMS are an important problem for Individuals involved in sexual offending. A consideration of these schemas in the psychotherapy of CSO’s would help develop new and effective therapeutic protocols designed to treat that particular population and reduce the rate of repeat offending.
Sauna use as an activity leading to a reduction in modifiable risk factors for the development of hypertension - a systematic review
Authors: Hunek Adrian , Góra Mateusz , Bigdoń Anna Maria , Ćwiek Maciej , Gorczyca Przemysław , Sydor Patryk , Kreft Rafał , Woźniak Aleksander , Wartacz Marcel , Kozłowska Martyna 
Published: June 2023

Background:
Hypertension prevalence is disturbingly increasing all over the world. Clinicians and patients are looking for new pharmacological as well as non-pharmacological methods to help fight too-high blood pressure.

Aim of this study:
The aim of this study is to present the current scientific literature on the potential that sauna bathing may help lower blood pressure, but additional data are needed to confirm these findings.

Material and methods:
A systematic review of the scientific and medical literature from the PubMed and Google Scholar databases was carried out. This was achieved according to the keywords: hypertension, sauna and sauna bathing. Items of literature were qualified for analysis.

State of knowledge:
Using the sauna is a pleasant way to spend time, and additionally it can have an impact on lowering blood pressure. During a sauna session, the superficial vessels dilate, which leads to a short-term decrease in blood pressure. And long-term, more frequent sauna use leads to a reduced risk of hypertension. Using the sauna enhances the effect of pharmacotherapy and non-pharmacological methods of fighting hypertension, such as physical activity and a healthy, balanced diet. Most of the research on the above topic was conducted in Finland, where its use has a centuries-old tradition.
Summary:
Using the sauna has an impact on lowering blood pressure values, thanks to which it can support the treatment of hypertension. Sauna use may be an interesting way to lower blood pressure values in physically disabled people. More studies conducted on larger groups of patients and the influence of other factors on blood pressure values are needed to make more accurate recommendations.