bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute number of three populations of interneurons and all GABAergic synapses in the human hippocampus
Authors: Takács Virág , Papp Péter , Orosz Áron , Bardóczi Zsuzsanna , Zsoldos Tamás , Zichó Krisztián , Watanabe Masahiko , Maglóczky Zsófia , Gombás Péter , Freund Tamás F. , Nyiri Gábor 
Published: September 2023

ABSTRACTThe human hippocampus, essential for learning and memory, is implicated in numerous neurological and psychiatric disorders, each linked to specific neuronal subpopulations. Advancing our understanding of hippocampal function requires computational models grounded in precise quantitative neuronal data. While extensive data exist on the neuronal composition and synaptic architecture of the rodent hippocampus, analogous quantitative data for the human hippocampus remain very limited. Given the critical role of local GABAergic interneurons in modulating hippocampal functions, we employed unbiased stereological techniques to estimate the density and total number of three major GABAergic cell types in the human hippocampus: parvalbumin (PV)-expressing, somatostatin (SOM)-positive, and calretinin (CR)-positive interneurons. Our findings reveal an estimated 49,400 PV-positive, 141,500 SOM-positive, and 250,600 CR-positive interneurons per hippocampal hemisphere. Notably, the higher proportion of CR-positive, primarily interneuron-selective, cells in humans, compared to rodents, may enhance local interneuron regulation. Additionally, using 3-dimensional electron microscopy, we estimated approximately 25 billion GABAergic synapses per hippocampal hemisphere, with PV-positive boutons comprising around 3.5 billion synapses, or 14% of the total GABAergic synapses. These findings contribute crucial quantitative insights for modeling human hippocampal circuits and understanding its complex regulatory dynamics.
How does language intensity of brand fan word-of-mouth (WOM) affect customers' willingness to adopt WOM? An empirical study based on psychological resistance theory
Authors: Zhang Depeng , Li Zhongxiang , Ma Jiaxin 
Published: September 2023

PurposeManaging the growing word-of-mouth (WOM) of brand fans has become a new challenge for companies in the fan economy era. The purpose of this paper is to examine the effect of language intensity of brand fan WOM on customers' willingness to adopt WOM based on psychological resistance theory and to reveal the underlying mechanism of this process.Design/methodology/approachA research model was developed to test the proposed hypotheses. Two experiments were conducted on an online platform using data from 708 participants. The independent samples t-test and analysis of variance were used to analyze the data.FindingsThe results show that, in the context of WOM among brand fans, high-intensity language leads to a lower willingness to adopt than low-intensity language and threats to freedom mediate this effect. Moreover, the restoration postscript moderates the effect of language intensity on threats to freedom and customers' willingness to adopt WOM.Originality/valueUnlike previous studies that focused on electronic word-of-mouth (eWOM) language content, this paper focuses on language intensity to reveal the psychological process of customers' willingness to adopt brand fan WOM. The findings not only enrich the research related to the language effect in eWOM, but also deepen the understanding of the influence effect on brand fan WOM, providing effective guidance for brands to manage fan WOM.
Feasibility study of eigenmode propagation through 2D models of vegetation
Authors: Csernyava Oliver , Pavo Jozsef , Badics Zsolt 
Published: September 2023

Purpose
This study aims to model and investigate low-loss wave-propagation modes across random media. The objective is to achieve better channel properties for applying radio links through random vegetation (e.g. forest) using a beamforming approach. Thus, obtaining the link between the statistical parameters of the media and the channel properties.

Design/methodology/approach
A beamforming approach is used to obtain low-loss propagation across random media constructed of long cylinders, i.e. a simplified two dimensional (2D) model of agroforests. The statistical properties of the eigenmode radio wave propagation are studied following a Monte Carlo method. An error quantity is defined to represent the robustness of an eigenmode, and it is shown that it follows a known Lognormal statistical distribution, thereby providing a base for further statistical investigations.

Findings
In this study, it is shown that radio wave propagation eigenmodes exist based on a mathematical model. The algorithm presented can find such modes of propagation that are less affected by the statistical variation of the media than the regular beams used in radio wave communication techniques. It is illustrated that a sufficiently chosen eigenmode waveform is not significantly perturbed by the natural variation of the tree trunk diameters.

Originality/value
As a new approach to obtain low-loss propagation in random media at microwave frequencies, the presented mathematical model can calculate scattering-free wave-propagation eigenmodes. A robustness quantity is defined for a specific eigenmode, considering a 2D simplified statistical forest example. This new robustness quantity is useful for performing computationally low-cost optimization problems to find eigenmodes for more complex vegetation models.
Comparing security perceptions and relationship configurations of mobile device modders and non-modders
Authors: Goode Sigi , Riaz Amir 
Published: September 2023

PurposeIt is becoming easier for end-users to modify their information system, sometimes against the wishes of management or the original manufacturer. In the mobile device context, “modding”, “jailbreaking” or “rooting” allows a mobile phone user to select operating software and network providers other than those mandated by the original provider. Prior studies have theorised that modders and non-modders possess different perspectives on the relationship between them and their device provider. However, these differences have not been empirically demonstrated in prior work. This paper aims to test theoretical pathways to explain the behavioural relationship effects of security within the modding context.Design/methodology/approachThis study models four relationship conceptualisations from prior research. The study tests this model using a survey of 464 mobile device users to compare the user attitudes of modders and non-modders.FindingsModder and non-modder relationships differ. Both groups value security, but in different ways: modder relationships are governed by satisfaction and commitment, while non-modder relationships are governed more by trust.Originality/valueTo the best of the authors’ knowledge, this is the first study to empirically demonstrate the relationship differences between IS modifiers and non-modifiers. Most published work has focused on IS that are unmodified. Incorporating device modification may improve behavioural understanding of end-users.
Indoor environmental quality and energy use intensity: an empirical post-occupancy evaluation test of on-campus university student housing in Ghana
Authors: Appau Williams Miller , Attakora-Amaniampong Elvis , Anugwo Iruka Chijindu 
Published: September 2023

PurposeTo significantly adopt and improve indoor energy efficiency in building infrastructure in developing countries can be a challenging venture. Thus, this study aimed to assess the satisfaction of indoor environmental quality and its effect on energy use intensity and efficient among student housing.Design/methodology/approachThe study is quantitative and hinged on the contrast theory. A survey of 1,078 student residents living in purpose-built student housing was contacted. Using Post-Occupancy Evaluation and Multiple Linear Regression, critical variables such as thermal comfort, visual comfort and indoor air quality and 21 indicators were assessed. Data on annual energy consumption and total square metre of the indoor area were utilised to assess energy use intensity.FindingsThe study found a direct relationship between satisfaction with indoor environmental quality and energy use intensity. The study showed that students were more satisfied with thermal comfort conditions than visual and indoor air quality. Overall, these indicators contributed to 75.9% kWh/m2 minimum and 43.2% kWh/m2 maximum energy use intensity in student housing in Ghana. High occupancy and small useable space in student housing resulted in high energy use intensity.Practical implicationsInclusions of sustainable designs and installation of smart mechanical systems are feedback to student housing designers. Again, adaptation to retrofitting ideas can facilitate energy efficiency in the current state of student housing in Ghana.Originality/valueEarlier studies have argued for and against the satisfaction of indoor environmental quality in student housing. However, these studies have neglected to examine the impact on energy use intensity. This is novel because the assessment of energy use intensity in this study has a positive influence on active design incorporation among student housing.
Nursing students’ experiences of learning practical gerontological nursing skills through online media during COVID-19 pandemic: a qualitative study
Authors: Niemtest Jaturada Jariyarattanakul , Tabootwong Watchara , Jullamate Pornchai 
Published: September 2023

Purpose
This study aims to explain the experiences of nursing students while they practiced gerontological nursing through online media during the COVID-19 pandemic.

Design/methodology/approach
Purposive sampling was used to select 20 third-year nursing students. Semi-structured face-to-face interviews were conducted with participants. The collected data were analyzed using the thematic analysis method to identify recurring themes and patterns.

Findings
Four themes emerged from the interviews, including improved practical skills, the impact of online learning, receiving support from close individuals and the need for support. Participants provided specific examples of how they improved their skills through online learning and described the importance of receiving support from those close to them during this challenging time.

Originality/value
Online media is essential for teaching nursing students during the COVID-19 pandemic. This is the main reason for teaching nursing students during times of restricted access to clinical settings. This research provides insights into the challenges and benefits associated with using digital platforms to teach gerontological practice for nursing students.
RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice
Authors: Brown Austin M. , Ganjayi Muni Swamy , Baumann Cory W. 
Published: September 2023

AbstractRAD140 is a selective androgen receptor modulator that produces anabolic effects within skeletal muscle. Thus, RAD140 may be effective at treating sarcopenia. No long‐term studies have investigated how RAD140 influences strength in ageing muscle. This study aimed to determine how 10 weeks of RAD140 supplementation impacts strength, recovery from exercise, and overall health in ageing mice. Young and adult females were assigned to receive RAD140 (5 mg/kg) or a control solution. Dorsiflexor muscles were exposed to repeated bouts of eccentric contractions, and torque was measured before and after each bout. Adaptive potential and strength gains were calculated to assess the efficacy of RAD140 in muscle, while frailty status and mortality risk were used to measure health span. Supplementation of RAD140 increased frailty status and mortality risk in the young and adult treated groups compared to the controls (p ≤ 0.042). RAD140 decreased adaptive potential in young (p = 0.040) but not adult mice (p = 0.688). Torque did not differ between groups after 2–3 weeks of recovery (p ≥ 0.135). In conclusion, long‐term RAD140 supplementation reduced indices of overall health and failed to improve strength in female mice, suggesting that RAD140 (at a 5mg/kg dosage) may be more detrimental than beneficial in delaying or preventing sarcopenia.
“Like aspirin for arthritis”: A qualitative study of conditional cyber‐deterrence associated with police crackdowns on the dark web
Authors: Décary‐Hétu David , Faubert Camille , Chopin Julien , Malm Aili , Ratcliffe Jerry , Dupont Benoît 
Published: September 2023

AbstractResearch summaryCrackdowns are law enforcement strategies based on the principles of deterrence theory, which stipulates that offenders are rational actors who will refrain from crime if perceived risks are higher than perceived benefits. Studies have shown that the effects of police street drug crackdowns are mostly short termed and followed by considerable displacement. In the early 2010s, an important part of illicit drug trades moved online to cryptomarkets, and law enforcement agencies have responded by engaging in online drug crackdowns. In this study, we focus on the perceptions of dark web users in order to determine, from a qualitative “data‐driven” perspective, whether police online crackdowns may have a cyber‐deterrent effect by analyzing 1796 forum posts. Our results show that these events trigger psychological and practical consequences that participants claim to have a conditional, although minor, deterrent effect. In the majority of cases, dark web users claimed to engage in several forms of spatial and tactical displacement.Policy implicationsOur study suggests that police crackdowns on the dark web have limited, short‐term effectiveness in curbing illicit activities. It proposes that innovative policing approaches such as problem‐oriented policing and “pulling levers/focused deterrence” strategies, which involve identifying key actors and engaging with them, be potentially extended to the dark web. While this approach is promising, it emphasizes the need for further research to assess its efficacy in the online realm, as it is a largely uncharted territory for law enforcement.
Chemical and physical properties of winter squash and their correlation with liking of their sensory attributes
Authors: Moreno Skylar R. , Sims Charles A. , Odabasi Asli , Simonne Amarat , Gao Zhifeng , Chase Carlene A. , Meru Geoffrey , MacIntosh Andrew J. 
Published: September 2023

AbstractCucurbita moschata, commonly known as squash or pumpkin, is a member of the Cucurbitaceae family originating from Central America. This species is regarded as heat tolerant and disease resistant and is commonly used in breeding programs. Calabaza (wintersquash) is an emerging market type of C. moschata with increasing popularity in the United States; however, limited research has been conducted to understand how sensory qualities influence consumers’ acceptability and willingness to pay (price). This study compared the sensory perception of C. moschata accessions grown in the continental southeastern United States with their physical and chemical properties using squash prepared from fresh and frozen states. The eight accessions investigated included five hybrids of calabaza from the University of Florida (University of Florida Tropical Pumpkin #), two commercial cultivars of calabaza (La Estrella and Soler), and one butternut squash cultivar (Waltham). The evaluation of fresh calabaza revealed significant differences in consumer preference among cultivars in addition to correlations with sensory attributes. UFTP8 and UFTP24 received the highest ratings, whereas UFTP38 and ‘La Estrella’ were rated lowest. Interestingly, the evaluation of frozen calabaza revealed UFTP8 and ‘Waltham’ Butternut squash as the highest in ranking, while UFTP38 and ‘La Estrella’ retained the lowest ranking. Consumer ratings of fresh samples revealed positive correlations between overall liking, sweetness liking, and texture liking with willingness to pay and soluble solids content (SSC). For calabaza intended for the frozen market, the color, hardness, and SSC were identified as the most significant parameters impacting willingness to pay. These results show how quality attributes can play a crucial role in consumers perception of quality and significantly influence their reported willingness to pay.Practical ApplicationProducers and breeders can use positively correlated attributes as indicators of overall liking and to determine pricing for C. moschata products.
Risk factors for ventilator‐associated lower respiratory tract infection in COVID‐19, a retrospective multicenter cohort study in Sweden
Authors: Forsberg Gustaf , Taxbro Knut , Elander Louise , Hanberger Håkan , Berg Sören , Idh Jonna , Berkius Johan , Ekman Andreas , Hammarskjöld Fredrik , Niward Katarina , Balkhed Åse Östholm 
Published: September 2023

AbstractBackgroundVentilator‐associated lower respiratory tract infections (VA‐LRTI) increase morbidity and mortality in intensive care unit (ICU) patients. Higher incidences of VA‐LRTI have been reported among COVID‐19 patients requiring invasive mechanical ventilation (IMV). The primary objectives of this study were to describe clinical characteristics, incidence, and risk factors comparing patients who developed VA‐LRTI to patients who did not, in a cohort of Swedish ICU patients with acute hypoxemic respiratory failure due to COVID‐19. Secondary objectives were to decipher changes over the three initial pandemic waves, common microbiology and the effect of VA‐LTRI on morbidity and mortality.MethodsWe conducted a multicenter, retrospective cohort study of all patients admitted to 10 ICUs in southeast Sweden between March 1, 2020 and May 31, 2021 because of acute hypoxemic respiratory failure due to COVID‐19 and were mechanically ventilated for at least 48 h. The primary outcome was culture verified VA‐LRTI. Patient characteristics, ICU management, clinical course, treatments, microbiological findings, and mortality were registered. Logistic regression analysis was conducted to determine risk factors for first VA‐LRTI.ResultsOf a total of 536 included patients, 153 (28.5%) developed VA‐LRTI. Incidence rate of first VA‐LRTI was 20.8 per 1000 days of IMV. Comparing patients with VA‐LRTI to those without, no differences in mortality, age, sex, or number of comorbidities were found. Patients with VA‐LRTI had fewer ventilator‐free days, longer ICU stay, were more frequently ventilated in prone position, received corticosteroids more often and were more frequently on antibiotics at intubation. Regression analysis revealed increased adjusted odds‐ratio (aOR) for first VA‐LRTI in patients treated with corticosteroids (aOR 2.64 [95% confidence interval [CI]] [1.31–5.74]), antibiotics at intubation (aOR 2.01 95% CI [1.14–3.66]), and days of IMV (aOR 1.05 per day of IMV, 95% CI [1.03–1.07]). Few multidrug‐resistant pathogens were identified. Incidence of VA‐LRTI increased from 14.5 per 1000 days of IMV during the first wave to 24.8 per 1000 days of IMV during the subsequent waves.ConclusionWe report a high incidence of culture‐verified VA‐LRTI in a cohort of critically ill COVID‐19 patients from the first three pandemic waves. VA‐LRTI was associated with increased morbidity but not 30‐, 60‐, or 90‐day mortality. Corticosteroid treatment, antibiotics at intubation and time on IMV were associated with increased aOR of first VA‐LRTI.
Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population‐based study
Authors: Lannoy Séverine , Ohlsson Henrik , Kendler Kenneth S. , Stephenson Mallory , Sundquist Jan , Sundquist Kristina , Edwards Alexis C. 
Published: September 2023

AbstractBackground and aimsAlcohol use disorder (AUD) is one of the strongest predictors of suicidal behavior. Here, we measured risk of suicide attempt and death as a function of AUD typologies.DesignWe used AUD typologies from previous latent class analysis: (i) externalizing subtype (characterized by externalizing symptomatology and early age of onset; individuals in this group have lower education and higher familial/social difficulties); (ii) subtype described by minimal psychopathology; and (iii) internalizing subtype (characterized by internalizing symptomatology and later age of onset; individuals in this group have higher education). We used class membership to predict distal outcomes (attempt and death) and performed regressions to evaluate whether differences in suicidal behavior were explained by the group characteristics (sex, age of onset, number and type of AUD registrations, familial/genetic risk for AUD, externalizing and internalizing behaviors, socio‐economic indicators, marital status and childhood family status). We also evaluated the effect of suicide attempt prior to AUD.Setting and participantsBased on longitudinal Swedish registry data, we included 217 074 individuals with AUD born 1950–80.MeasurementsSuicide attempts were identified using medical registers and deaths using the mortality register.FindingsIndividuals with the externalizing subtype had higher risks of suicidal behavior than other groups [attempt: externalizing versus minimal psychopathology: odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.35, 1.35; externalizing versus internalizing: OR = 1.47, 95% CI = 1.46, 1.48; death: externalizing versus minimal psychopathology: OR = 1.57, 95% CI = 1.57, 1.58; externalizing versus internalizing: OR = 1.99, 95% CI = 1.93, 2.06]. Individuals with minimal psychopathology had higher risks than those with internalizing symptomatology (attempt: OR = 1.09, 95% CI = 1.08, 1.10, death: OR = 1.26, 95% CI = 1.23, 1.30). These differences were explained by age at registration and were related to the number of registrations, sex, education, family disruption and suicide attempt prior to AUD.ConclusionsAmong people in Sweden, considering alcohol use disorder (AUD) heterogeneity appears to be a meaningful way to evaluate suicide risk. The highest risk of suicide attempt and death occurs in the externalizing subtype of AUD, followed by the minimal psychopathology subtype, and then the internalizing subtype.
Evidence for the role of multidisciplinary team care in people with pelvic pain and endometriosis: A systematic review
Authors: Fang Qing Yi , Campbell Nikki , Mooney Samantha S. , Holdsworth‐Carson Sarah J. , Tyson Kate 
Published: September 2023

BackgroundEndometriosis is a chronic, inflammatory condition characterised by the presence of endometrial‐like tissue outside the uterine cavity. Given the multi‐system nature of the disease and the potential for significant negative impact on quality of life, there has been a long‐standing recognition of the need for multidisciplinary care for people with endometriosis. However, there is paucity to the data supporting this approach, and much of the evidence is anecdotal.AimThis systematic review aims to describe recent evidence‐based models and patient‐centred perspectives of multidisciplinary care for endometriosis, to improve understanding of the role of an integrated, multidisciplinary team in effectively addressing patients' care needs.Materials and MethodsPubMed, Medline, Embase and Web of Science were searched for relevant articles published between 1 January 2010 to 7 July 2022.ResultsNineteen studies met the inclusion and exclusion criteria and pinpointed a multidisciplinary team consisting of gynaecologists, pain specialists, nurses, physiotherapists, psychologists, sex therapists, nutritionists, complementary medicine practitioners, and social workers to be most commonly utilised in holistically managing people with pelvic pain and endometriosis. Furthermore, patient perspectives on care highlighted the need for reliable information, respect and validation of experiences or preferences, discussion of long‐term treatment plans and social and emotional supports.ConclusionThe trend for multidisciplinary team care for people with endometriosis is growing. Further consumer‐driven clinical studies and outcome evaluations need to be conducted to determine the effect of multidisciplinary care on improvements to quality of life for people living with endometriosis and or pelvic pain.