bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological substantiation of laser exposure parameters and modes for surgical treatment of intrauterine pathology
Authors: Kazachkov E. L. , Safronov O. V. , Kazachkova E. A. , Ignatieva E. N. , Safronova I. V. , Tarasova L. B. 
Published: May 2023

Introduction No data on experimentally substantiated parameters and modes of diode laser radiation allowing a minimally traumatic surgical treatment of intrauterine pathology have been found in the literature.The aim of the investigation was to substantiate experimentally the optimum parameters and modes of diode laser radiation in the treatment of intrauterine pathology based on the study of morphological changes in the endometrium.Materials and methods 48 endometrial samples were exposed to 10-40 W diode laser power in a constant mode and 15 samples - in a pulsed mode with 3 different sets of laser exposure parameters. The data were statistically processed using Microsoft Excel spreadsheets, version 16.49. The differences were considered statistically significant at р<0.05.Results Width of the ablation zone, lateral coagulation and hyperthermic exposure zone was calculated at the most optimal parameters of laser energy (20 W), achieving adequate cutting and bleeding properties of the laser. The most effective in the pulsed mode of laser operation was 30 W amplitude power of radiation, the pulse duration of 100 ms, the duration of the interval between pulses of 50 ms, the average power of 20 W.Discussion Comparative analysis of morphometric parameters in the action of laser radiation in the constant mode with a radiation power of 20 W and in the pulsed mode with an average laser power of 20 W has shown that the structural parameters have significantly lower values in the pulsed laser mode.Conclusion Optimal cutting properties of the laser are observed when constant laser irradiation with a power of 20 W is used. The best cutting and bleeding properties were demonstrated by the pulsed laser mode with an average power of 20 W, amplitude power of 30 W, pulse duration of 100 ms, and inter-pulse interval of 50 ms.
PDCD4 and CDX-2 as immunohistochemical markers of gastric mucosa atrophy in chronic gastritis
Authors: Rubtsov V. A. , Shimanskaya A. G. , Parygina М. N. , Mozgovoi S. I. , Pomorgailo E. G. , Kononov A. V. 
Published: May 2023

Introduction Diagnosis of the gastric mucosa atrophy represents an important problem, the solution of which depends on the possibility of secondary prevention of gastric cancer. A possible way of solution is the use of immunohistochemical markers - proteins associated with cellular remodeling of gastric mucosa, PDCD4 and CDX2.The aim of the work is to evaluate the possibility of using immunohistochemical markers PDCD4 and CDX-2 to diagnose atrophy of the gastric mucosa in chronic gastritis and increase the informative value of biopsy examination.Materials and method The object of the study was 155 cases of biopsy examination of the gastric mucosa of patients with chronic gastritis (5 fragments per case − 775 biopsy specimens). A comparative semi-quantitative assessment of immunohistochemical expression of CDX2, PDCD4 at different stages of chronic gastritis was performed. Spearman correlation coefficient was used to assess correlation relationship.Results There were no statistically significant differences in the level of PDCD4 in studied samples depending on the stage of chronic gastritis, p=0.06. Statistically significant increase of CDX2sum index in progressing stage of chronic atrophic gastritis (p=0.005), demonstrated a pronounced positive correlation r=0.70 (p<0.01).Discussion According to the results obtained, it is shown that the decline in PDCD4 protein does not occur with the progression of atrophy severity. Complementary use of immunohistochemical marker CDX2 is able to give an idea of the presence and severity of both metaplastic and absolute atrophic changes in the gastric mucosa.Conclusion Equally high level of PDCD4 protein index in the gastric mucosa at different stages of chronic gastritis excludes the possibility of its use as an immunohistochemical marker of atrophy. Semi-quantitative immunohistochemical index of CDX2 protein can be used as an additional marker in decision support system for assessment of atrophic changes in gastric mucosa.
CDX2 protein distribution in the gastric mucosa in chronic gastritis by a semi-quantitative index and its reproducibility
Authors: Parygina M. N. , Mozgovoi S. I. , Shimanskaya A. G. , Rubtsov V. A. , Ostroglyadova I. A. , Kononov A. V. 
Published: May 2023

Introduction The Cdx2 gene provides an intestinal differentiation of epithelial cells and plays an oncosupressive role. An indirect method of the Cdx2 gene expression assessment is the immunohistochemical study of its product, the CDX2 protein. Therefore, the common approach to the immunohistochemical study of the CDX2 protein hasn’t been developed yet. A semi-quantitative CDX2 index based on the percentage of CDX2-positive cells in the tissue specimen, the staining intensity and an expression pattern has been proposed.The purpose of the study was to assess the reproducibility of the semi-quantitative CDX2 index calculation in chronic atrophic gastritis stages I-IV.Materials and methods 20 chronic atrophic gastritis cases (5 cases for each stage of the gastritis according to the Operative link for gastritis assessment system) were taken according to the Maastricht V protocol and examined by the immunohistochemical method (CDX2, clone EPR2764Y, ready to use). The reproducibility of the CDX2 semi-quantitative index was assessed by five pathologists. An agreement between observed raters was measured by the kappa statistics.Results The Cohen’s κ value is 0,8 for unweighted κ and 0,97 for weighted κ (extremely high level of agreement) for the semi-quantitative CDX2 index calculation.Discussion The least reproducible parameter used for the semi-quantitative CDX2 index calculation the percentage of CDX2-positive cells because of the subjective assessment. The Cohen’s weighted κ value was higher compared to the unweighted κ because of the close yet not similar CDX2 semi-quantitative index values calculated by pathologists.Conclusion The semi-quantitative CDX2 index can be used to rank CDX2 expression and has a high level of reproducibility.
Safe and Aesthetic; Laparoscopic Cholecystectomy on The Bikini Line
Authors: ERDOĞAN Emre , DURSUN Ayberk , GÜLER Mert 
Published: April 2023

Objective: Laparoscopic cholecystectomy (LC) is the gold standard treatment for symptomatic cholelithiasis and is the most commonly performed surgical procedure worldwide. It is superior to open cholecystectomy in terms of aesthetics, but the visibility of the trocar ports is a cosmetic problem due to increasing aesthetic concerns. We report the results of patients who underwent conventional four port LK with all incisions below the bikini line.
Material and Method: The study included patients who underwent LK through bikini incision in our clinic between 01.11.2020 and 31.11.2021. Age, gender, comorbidities, indications for cholecystectomy, previous abdominal surgeries, anesthesia scores, and body mass index (BMI) were recorded. The procedure was not performed in patients undergoing emergency surgery for acute cholecystitis and other causes.
Results: The study included 9 patients, all of whom were female. The mean age was 30 ± 7.8 years and mean BMI was 23.1 ± 4.3. Mean operative time was 33.9 ± 8.5 minutes. Open operation was not performed in any patient. The hospitalization period was one day for all patients. There were no complications in any of the patients. Eight of the nine patients (89%) expressed cosmetic satisfaction in the first month after surgery.
Conclusion: The prevalence of LC leads to an increase in the number of patients expecting less scarring. Here, we propose a modified four-port laparoscopic cholecystectomy that is easy to perform, safe, requires no additional cost, and has high patient satisfaction
Comparison Of Vitamin B12 Values and Kidney Function Tests in Patients Diagnosed with FMF and Gout Under Colchicine Treatment
Authors: URAL ULUCAN Hesna , YILMAZ Didem , ÖZDEMİR Fulya , ACAR Elif Burcu , KEÇECİ Erkan 
Published: April 2023

FMF (Familial Mediterranean Fever); It is a hereditary disease that manifests itself with recurrent periodically increasing fever and abdominal pain, lung and joint pain. It is defined as an autoinflammatory disease that continues with inflammatory attacks that the body repeats itself due to genetic reasons.
GOUT is a hereditary disease that occurs as a result of a disorder of purine metabolism. It is a form of inflammation that causes pain, swelling, redness, tenderness, and increased temperature in the joints. Purine is one of the nitrogenous compounds that break down into uric acid in the body. With the increase in the levels of uric acid in the blood, the uric acid crystallizes and accumulates in the joints, tendons, and surrounding tissues.
Colchicine is an alkaloid obtained from the seeds of the Colchicum Autumnale L plant, which is used in the treatment of rheumatic diseases such as FMF and GOUT. It is an antimitotic agent that binds to intracellular tubulin protein and inhibits the polymerization of new microtubules. It shows its effect through microtubules. Colchicine treatment in FMF patients prevents the development of amyloidosis and attacks. Thus, as well as preventing acute attacks, it also slows down the formation of amyloidosis, the most important side effect of the disease.
In this review, the studies on the subject are examined. Vitamin B12 and renal function tests were compared in patients with FMF or GOUT who received colchicine therapy.
Diabetes Risk Score of Adult Applications to Primary Health Care Center: A Cross-Sectional Study
Authors: EVCİMEN Hasan , İŞCAN AYYILDIZ Neşe , DOĞAN Ufuk 
Published: April 2023

Objective: Diabetes is a serious public health problem that has increased in frequency in recent years. The aim of this study is to determine the diabetes risk scores of individuals who apply to a primary health care institution.
Material-method: This descriptive and cross-sectional study was conducted with 982 individuals between 01.12.2021 and 12.03.2022. Data were collected from the sociodemographic characteristics questionnaire and the Finnish Diabetes Risk Score (FINDRISC) questionnaire. Those with a diabetes risk score of 15 or higher were considered high risk.
Results: The mean age of the individuals participating in the study was 37.93±8.63. The mean FINDRISC score of the participants was 8.52±6.83 and 22.8% of them were in the high-risk group. The women included in the study, those who are married, have a low education level, have a low income, have a high BMI, do not exercise, and have a family history of diabetes have a higher risk of diabetes.
Conclusion: Approximately one in four people in the study appear to be at high risk. Primary health care institutions need to conduct risk screenings more frequently. Lifestyle interventions to reduce the preventable risk factors of individuals should be developed and supported.
Keywords: Diabetes, FINDRISC, Primary care, Adults, Score
Non-Hodgkin Lenfoma Olgularının Geriye Dönük Değerlendirilmesi: Tek Merkez Deneyimi
Authors: ASLANER AK Müzeyyen , ÇEKİM İlknur , ERTOP Şehmus 
Published: April 2023

AAmaç: Çalışmamızda Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Hematoloji Kliniğinde takip edilen 151 Non- Hodgkin lenfoma tanılı hastanın demografik verileri, tedavi yanıtları ile sağkalım analizlerinin yapılması amaçlandı.
Materyal ve Metod: Non- Hodgkin lenfoma tanısı ile izlenen 151 olgunun verileri geriye dönük olarak değerlendirildi.
Bulgular: Çalışmaya 151 hasta (81 kadın,70 erkek) dahil edildi. Ortanca yaş 62.6±12.9 olarak saptandı. Hastaların tanılarına bakıldığında 83(%55) hastanın diffüz büyük B hücreli lenfoma, 21(%13.9) hastanın marjinal zon lenfoma, 10(%6.6) hastanın foliküler lenfoma 26 (%17.2) hastanın mantle cell lenfoma, 9(%6.0) hastanın T hücreli lenfoma, 2(%1.3) hastanın diğer lenfoma tanısı aldığı görüldü. Hastaların 64’si tanesi ölmüş, 87 tanesi ise yaşıyor olarak saptandı. Tüm non-hodgkin lenfoma hastalarında ortalama sağ kalım süresi 64 ay iken hastalıksız sağ kalım süresi 63 ay saptandı.
Sonuç: Çalışmamızda 5 yıllık sağkalım oranı literatüre göre düşük saptandı. Bunun sebebi hasta popülasyonumuzun büyük çoğunluğunun 65 yaş üstü olması, ileri evre hastalık ve komorbidite oranının yüksek olmasına bağlı olduğunu düşünüyoruz.
ANALISIS PENGARUH UTANG LUAR NEGERI (FOREIGN DEBT) TERHADAP PERTUMBUHAN EKONOMI
Authors: Haryanti Nik , Sona Muklas Ary 
Published: April 2023

Indonesia, sebagai negara sedang membangun, memiliki pertumbuhan ekonomi yang bagus di tahun 1990-an. Ini ditunjukkan dengan peningkatan GDP tahun per tahun, stabilitas inflasi, dan sebagainya. Tetapi sejak tahun 1997 krisis ekonomi yang melanda negara-negara Asia, pertumbuhan ekonomi Indonesia mengalami penurunan. Itu berakibat pada sektor moneter dan sektor riil, dan ditambah lagi dengan semakin meningkatnya jumlah utang luar negeri Indonesia sebagai akibat dari nilai tukar rupiah yang semakin terus menurun karena utang luar negeri Indonesia seluruhnya dalam bentuk Dollar Amerika.
Tujuan dalam penelitian ini untuk mengetahui pengaruh Utang Luar Negeri (foreign debt) terhadap pertumbuhan ekonomi Indonesia. Kemudian untuk mengetahui pengaruh Penanaman Modal Asing (PMA) terhadap pertumbuhan ekonomi Indonesia. Ruang lingkup penelitian ini adalah mengenai utang luar negeri (foreign debt) dan Penanaman Modal Asing (PMA) sebagai determinan pertumbuhan ekonomi periode 1986-2005.
Model analisis yang digunakan adalah model ekonometrika. Metode analisis yang dipakai dalam model adalah metode OLS (Ordinary Least Squares) atau Metode Kuadrat Terkecil Biasa. Metode ini dikemukakan oleh Carl Friedrich Gauss.
Hasil penelitian ini menunjukkan perkembangan pertumbuhan ekonomi Indonesia selama kurun waktu penelitian menunjukkan perkembangan yang fluktuatif. Kemduian perkembangan utang luar negeri (foreign debt) Indonesia selama kurun waktu penelitian menunjukkan perkembangan yang fluktuatif pada pertengahan dasawarsa 1990-an
ANALISIS PENGGUNAAN SELEBRITI SEBAGAI ENDORSER TERHADAP BRAND ASSOSIATION PRODUK
Authors: Mas'ut Mas'ut , Marsono Adi 
Published: April 2023

Persaingan dunia usaha yang semakin ketat khususnya dalam bidang pengobatan mengharuskan para produsen jamu bersaing di pasar untuk mempertahankan produknya. Produk yang memiliki kualitas, model dan features yang relatif sama dapat memiliki kinerja yang berbeda da pasar, hal ini disebabkan karena adanya perbedaan persepsi di benak konsumen.
Jenis data yang digunakan dalam penelitian ini meliputi dua macam jenis data, yaitu data primer dan data sekunder. Metode pengumpulan data dalam penelitian ini melalui dua tahap, yaitu persiapan penelitian dan penelitian pokok. Teknik analisa yang digunakan dalam penelitian ini menggunakan uji Cohran. Untuk mengetahui asosiasi-asosiasi apa saja yang terbentuk dari artis Sophia Latjuba sebagai endorser produk jamu Tolak Angin Sido Muncul versi “orang pintar”. Untuk mengetahui asosiasi-asosiasi apa saja yang terbentuk dari produk jamu Tolak Angin Sido Muncul. Untuk mengetahui bagaimana hubungan penggunaan selebritis sebagai endorser terhadap brand association produk jamu Tolak Angin Sido Muncul
Hasil penelitian menunjukkan dari semua kesan yang ada atau terbentuk dari artis Shophia Latjuba sebagai endorser produk jamu Tolak Angin Sidomuncul tidak semua kesan tersebut akan membentuk assosiasinya, tetapi hanya ada empat kesan yang membentuk brand asotiation dari endorser. Asosiasi-asosiasi tersebut adalah: Berpengetahuan, Berkualitas, Populer dan Menarik.
OPTIMALISASI DIGITAL ENTREPRENEURSHIP MELALUI PELATIHAN STARTUP DIGITAL BAGI KALANGAN REMAJA DI KECAMATAN KUTA SELATAN
Authors: Komang Hari Santhi Dewi  , I Putu Gd Abdi Sudiatmika  , I Gusti Ayu Sri Melati  , Rifky Lana Rahardian  , A.A. Raka Jayaningsih  
Published: May 2023

Program Kemitraan Masyarakat ini bertujuan untuk mengoptimalkan pemahaman dan implementasi digital entrepreneurship melalui pelatihan startup digital di kalangan remaja. Pada Program Kemitraan Masyarakat (PKM) dilakukan pelatihan dalam merancang ide dan business plan dengan kriteria target pencapaian 80-100%. Kegiatan ini diikuti oleh 25 orang yang berasal dari seka truna-truni di Kecamatan Kuta Selatan. Kegiatan pelatihan dilakukan secara luring dengan melibatkan akademisi dan praktisi. Kegitan ini dibagi menjadi beberapa tahapan kerja yaitu; Perencanaan, Pelaksanaan, Observasi, Evaluasi dan Refleksi. Hasil kegiatan pengabdian ini menunjukkan bahwa sebelum pelatihan konsep startup, merancang ide startup dan menyusun business plan adalah sebesar 36% dan setelah kegiatan meningkat menjadi 64% dengan kategori sangat baik. Seluruh peserta memberikan respon positif terhadap pelaksanaan kegiatan pengabdian masyarakat dan kegiatan ini diharapkan dapat berlangsung secara berkesinambungan.
ANALISIS KINERJA KEUANGAN SEBELUM DAN SESUDAH RIGHT ISSUE (STUDI EMPIRIS PADA PERUSAHAN YANG TERDAFTARDI BURSA EFEK INDONESIA TAHUN 2017-2020)
Authors: Al Qoidah Istiqomah , Moh Halim  , Rendy Mirwan Aspirandi  
Published: April 2023

ABSTRACT
The Purpose of this study was to analyze the diffrences in financial performance before and after right issue.. The variables used are return on assets (ROA), debt to equity ratio (DER), current ratio (CR) and price to book value (PBV). The data taken is 2 years before the rights issue, namely in 2017-2018 and after the rights issue 2019-2020. The sample used as many as 20 companies listed on the IDX. The results of the study show that there is no effect on return on assets between before and after the rights issue to earn profits not only through the rights issue. The debt to equity ratio has an effect between the time before and after the rights issue. This shows that the company uses the proceeds from the rights issue. to pay off his debts. The current ratio has no effect between the time before and after the right issue. This shows that the company in paying off its short-term obligations with its assets, there is no comparison between the time before and after the right issue. Price to book value has no effect between the time before and after the right issue. . This shows that the company after carrying out the rights issue activity that most of the proceeds from the rights issue were used for industrial capital accumulation.
IMPACT OF THE COVID-19 PANDEMIC ON THE PRICE AND VOLUME OF STOCK TRANSACTIONS IN HOSPITALS IN INDONESIA
Authors: Tarigan Pelinta , Christelia Silvia , Chintya Wangsih Ingkak , Yohana  
Published: April 2023

The aim of the study was to look at the comparison between stock prices and hospital transaction volume before and after the announcement of the first COVID-19 pandemic in Indonesia.
The population in this study is a hospital listed on the Indonesia Stock Exchange (IDX). Samples in this study used purposive sampling techniques, hospital data obtained by as many as 6 companies listed on the Indonesia Stock Exchange (IDX), this study used paired sample t-test techniques and data process using SPSS version 26.
The result of this study is the stock price of hospitals before and after the announcement of COVID-19 cases in Indonesia is very significant with sig value. (2tailed) the result is 0,000 (p < 0.05) meaning that significant changes (mean) and for the Volume of Hospital Transactions before and after the announcement of COVID-19 cases in Indonesia is very significant with sig value. (2 tailed) the result is 0.033 (p < 0.05) meaning a significant change (meaning).
DETERMINAN PENDAPATAN PEDAGANG PASAR PALUR KABUPATEN KARANGANYAR
Authors: Mei Puspitasari  , Ismunawan  
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh modal usaha, lama usaha, jam kerja dan lokasi terhadap pendapatan pedagang Pasar Palur Kabupaten Karanganyar. Metode penelitian ini menggunakan kuantitatif dengan objek pedagang Pasar Palur Kabupaten Karanganyar. Teknik penarikan sampel menggunakan probability sampling sebanyak 85 responden dengan rumus slovin melalui penyebaran kuesioner secara random. Adapun analisis data meliputi (1) pengujian instrumen data yaitu uji validitas serta uji reliabilitas, (2) pengujian asumsi klasik berupa uji normalitas, uji multikolinieritas dan uji heteroskedastistas, (3) regresi linier berganda serta pengujian hipotesis terdiri koefisien determinasi(R2), Uji F dan uji t dengan aplikasi SPSS versi 25. Hasil riset yang dilakukan ini menunjukkan variabel modal usaha, lama usaha, jam kerja dan lokasi secara simultan memberikan pengaruh signifikan terhadap pendapatan pedagang Pasar Palur Kabupaten Karanganyar. Secara parsial, variabel modal usaha, jam kerja dan lokasi berpengaruh signifikan terhadap pendapatan pedagang Pasar Palur Kabupaten Karanganyar. Sementara variabel lama usaha tidak berpengaruh signifikan terhadap pendapatan pedagang Pasar Palur Kabupaten Karanganyar.
PENETAPAN UPAH BURUH SESUAI PERSPEKTIF EKONOMI ISLAM PADA PR ALFI PUTRA KABUPATEN TRENGGALEK
Authors: Ade Ana Saputri  , Mochamad Chobir Sirad  
Published: April 2023

Perusahaan Rokok Alfi Putra merupakan usaha dibidang pembuatan rokok yang sangat terkenal di Kabupaten Trenggalek dan memiliki beberapa tempat pabrik di wilayah Trenggalek. Namun Peneliti memfokuskan penelitian perusahaan rokok Alfi Putra yang berada di Kecamatan Kampak Kabupaten Trenggalek. Tujuan dalam penelitian ini adalah: (1) untuk mengetahui mekanisme Upah buruh PR Ali Putra dalam perspektif Ekonomi Islam, (2) untuk mengetahui Faktor apa saja yang menjadi penghambat buruh mendapatkan upah yang layak dalam perspektif ekonomi Islam di PR Alfi Putra. Adapun Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Penentuan informan penelitian menggunakan purposive sampling yang terdiri dari 11 orang informan. Hasil dalam penelitian ini adalah bahwa Upah buruh PR Ali Putra dalam perspektif Ekonomi Islam. Upah buruh yang diberikan oleh PR Alfi Putra kepada karyawannya belum bisa di bilang layak karena belum memenuhi pokok-pokok upah dalam perspektif ekonomi Islam. Faktor yang menjadi penghambat buruh mendapatkan upah yang layak dalam perspektif ekonomi Islam di PR Alfi Putra. Pertama, belum ada keputusan dari pimpinan pusat yang akan menaikan gaji. Kedua, terbatasnya anggaran yang dimiliki oleh pihak usaha. Ketiga, susahnya untuk mendapatkan pekerjaan sehingga pihak usaha dengan leluasa memberikan upah. Keempat Belum ada peraturan pemerintah untuk upah yang layak di tingkat Kabupaten.
POTENSI EKSPOR BRIKET TERHADAP PEREKONOMIAN INDONESIA
Authors: Sinaga Grace Yoan Grasella , Jessica Ayu Katherine  , Muhammad Daffa Akhsya  , Putri Rahmadina  , Saied Idris Baidhowi  
Published: April 2023

Indonesia adalah salah satu negara pengekspor bahan bakar alternatif pengganti energi fosil atau bisa disebut dengan briket, Indonesia tercatat mengekspor briket ke dunia sebanyak 467,050 ton. Negara tujuan ekspor briket Indonesia adalah negara-negara maju, dan dengan nilai yang cukup besar tersebut maka apakah ekspor briket berpotensi pada perekonomian Indonesia. Tujuan dari penelitian ini adalah untuk mengetahui besarnya potensi ekspor briket terhadap perekonomian Indonesia. Menggunakan sumber data ekspor briket tempurung kelapa tahun 2017 - 2021, data PDB Indonesia tahun 2017 – 2021, serta data moneter yang didapatkan dari UN Trade, WDI, dan lainnya. Menggunakan metode teknik analisis kuantitatif perhitungan statistik regresi linear berganda diaplikasikan menggunakan R Studio dan plot error dan juga penjabaran deskriptif. Penelitian tersebut menghasilkan bahwa ekspor briket Indonesia memiliki 0,00018% potensi dalam perekonomian Indonesia, untuk menghasilkan potensi yang besar, maka dibutuhkan eksportir yang memberikan harga ekspor besar untuk mempengaruhi kenaikan perekonomian Indonesia.