bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summary of methodology used in enterotoxigenicEscherichia coli(ETEC) challenge experiments in weanling pigs and quantitative assessment of observed variability
Authors: Dahmer Payton L , DeRouchey Joel M , Gebhardt Jordan T , Paulk Chad B , Jones Cassandra K 
Published: July 2023

AbstractPostweaning diarrhea in pigs is often caused by the F4 or F18 strains of enterotoxigenic Escherichia coli (ETEC). To evaluate interventions for ETEC, experimental infection via a challenge model is critical. Others have reviewed ETEC challenge studies, but there is a lack of explanation for the variability in responses observed. Our objective was to quantitatively summarize the responses and variability among ETEC challenge studies and develop a tool for sample size calculation. The most widely evaluated response criteria across ETEC challenge studies consist of growth performance, fecal consistency, immunoglobulins, pro-inflammatory cytokines, and small intestinal morphology. However, there is variation in the responses seen following ETEC infection as well as the variability within each response criteria. Contributing factors include the type of ETEC studied, dose and timing of inoculation, and the number of replications. Generally, a reduction in average daily gain and average daily feed intake are seen following ETEC challenge as well as a rapid increase in diarrhea. The magnitude of response in growth performance varies, and methodologies used to characterize fecal consistency are not standardized. Likewise, fecal bacterial shedding is a common indicator of ETEC infection, but the responses seen across the literature are not consistent due to differences in bacterial enumeration procedures. Emphasis should also be placed on the piglet’s immune response to ETEC, which is commonly assessed by quantifying levels of immunoglobulins and pro-inflammatory cytokines. Again, there is variability in these responses across published work due to differences in the timing of sample collection, dose of ETEC pigs are challenged with, and laboratory practices. Small intestinal morphology is drastically altered following infection with ETEC and appears to be a less variable response criterion to evaluate. For each of these outcome variables, we have provided quantitative estimates of the responses seen across the literature as well as the variability within them. While there is a large degree of variability across ETEC challenge experiments, we have provided a quantitative summary of these studies and a Microsoft Excel-based tool was created to calculate sample sizes for future studies that can aid researchers in designing future work.
Within‐person associations between alcohol use and memory lapses among middle‐aged and older adults
Authors: Miller Sara E. , Mogle Jacqueline A. , Linden‐Carmichael Ashley N. , Almeida David M. 
Published: July 2023

AbstractIntroductionAlcohol use has been linked to impairment in both short‐ and long‐term measures of objective memory. However, limited research has investigated the association between alcohol use and subjective memory in everyday life. The study purpose was to investigate within‐ and between‐person associations between daily alcohol use and prospective (i.e., forgetting an intended task) and retrospective (i.e., forgetting something learned in the past) memory lapses among middle‐aged and older adults.MethodsParticipants (n = 925; Mage = 55.2) were non‐abstaining adults from the Midlife in the United States (MIDUS) study or the MIDUS Refresher who participated in an 8‐day telephone diary asking about their daily experiences.ResultsMultilevel models revealed that within‐individuals, heavier‐than‐usual alcohol use (i.e., having more drinks than one's daily average number of drinks) was associated with greater odds of reporting any memory lapses (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.01, 1.12), while associations at the between‐person level were nonsignificant (OR 1.07; 95% CI 0.99, 1.16). When assessing retrospective and prospective lapses separately, alcohol use was only associated with prospective lapses and only at the between‐person level (OR 1.10; 95% CI 1.01, 1.19). Finally, alcohol use was unassociated with reported irritation or interference from memory lapses (p > 0.05).Discussion and ConclusionsHeavier‐than‐usual alcohol use may have acute effects on daily memory functioning. Future studies should assess how alcohol use relates to an individual's ability to meet daily cognitive demands, as these findings may have critical implications for harm reduction efforts targeting daily functioning among older adults.
Experiential learning of management principles via online student‐manager discussions
Authors: Fish Lynn A. 
Published: July 2023

AbstractThis teaching brief describes an experiential project used in a graduate Principles of Management course for nonbusiness undergraduate students. Groups of four to six first‐year MBA students interviewed a seasoned manager online twice over the 8‐week course and discussed the applications of course material. Project subtopics included an introduction to management, strategic management, ethics and social responsibility, innovation and change management, international business, organizational structure, authority and job design, human resource management, leadership, and communication, operations management, and business analytics. Students completed a group report and an individual reflection on their experience. Over 92% of graduate students in the class indicated that the project was a positive learning activity.
Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis
Authors: Yin Saifu , Zhou Zhaoxia , Wu Jiapei , Wang Xianding , Lin Tao 
Published: July 2023

AbstractBackgroundConflicting results have been reported regarding the association between psoriasis and risk of chronic kidney diseases (CKD). Furthermore, the causal nature of the possible association remains unexplored.MethodsWe conducted a population‐based cross‐sectional study using data from National Health and Nutrition Examination Survey (NHANES). Logistic regression analyses were conducted to estimate potential association between psoriasis and CKD risk. Further, we evaluated causality by performing a Mendelian randomization analysis using large‐scale genome‐wide association studies of psoriasis and CKD. Inverse variance‐weighted (IVW) analysis was used as the primary method.ResultsIn the observational study, 16 750 participants were included. Overall, 39 of 429 patients with psoriasis had CKD (9.1%) compared with 1481 of 16 321 without psoriasis (9.1%). In the fully adjusted model, psoriasis was not associated with CKD (OR: 0.77, 95%CI: 0.53–1.10). In the MR analysis, 36 single‐nucleotide polymorphisms (SNPs) were selected as instrumental variables. The IVW analysis reported that genetically predicted psoriasis was associated with a higher risk of CKD (OR: 1.025, 95%CI: 1.001–1.049). After removing 2 SNPs associated with heterogeneity, the association remained (OR: 1.028, 95%CI: 1.006–1.050).ConclusionGenetically predicted psoriasis was associated with a higher risk of CKD. This association may be important for clinicians to monitor kidney function and prescribe potentially nephrotoxic drugs during psoriasis management.
An immersive simulation strategy to teach canine vaginal cytology: A multi‐centre study
Authors: Marcos Ricardo , Moreira Raquel , Macedo Sónia , Mateus Luisa , Martins‐Bessa Ana , Lopes Graça 
Published: July 2023

AbstractVaginal cytology (VC) is an essential technique for monitoring the bitch's estrus cycle. Currently, animal‐free teaching methodologies have not been investigated for VC. Hence, this study aimed to evaluate an immersive simulation with a VC model and augmented reality tools. Students (n = 219) from four universities were enrolled, having learning stations with models for practising VC that provided immediate feedback on the technique. Augmented reality tools comprised QR codes that endorsed students to short videos of owners' avatars reporting the clinical reproductive story of the simulated animals and slides with QR codes leading to microscopy slide navigation videos. Proestrus, estrus, diestrus, anestrus and vaginitis were identified in the learning stations. The students' perceptions were evaluated through questionnaires assessing satisfaction, motivation, confidence, impact on learning and diagnostic accuracy. Before the immersive simulation, students had no experience with VC, being afraid of doing a VC with a live dog. Almost all the students considered practicing VC as essential and 94% reported that repeating the procedure (>2 times) was the most important parameter for learning. The simulation activity lasted ≈3 h and significantly improved the confidence of students, being less afraid of doing a VC in a live animal. Slide navigation videos improved the diagnostic accuracy of the estrus cycle stage, and students diagnosed the estrus and vaginitis cases more accurately. The immersive simulation strategy allowed repeated practice in a safe, motivated and standardized environment, being appraised by students as an essential strategy for learning VC.
Therapeutic solutions for anterior restorations in disabled patients: Systematic review and case report
Authors: Abouzeir Salomé , Gurgel‐Georgelin Marie , Diemer Franck , Esclassan Rémi , Noirrit‐Esclassan Emmanuelle , Canceill Thibault 
Published: July 2023

AbstractIntroductionTreating anterior restorations is a real challenge for a dentist and conventional protocols are not always applicable. The aim of this study is to determine different therapeutic to conducting anterior restorations in disabled people.Case reportWe begin by presenting the case of a 23‐year‐old, handicapped man, who was brought in consultation to compensate for the loss of the left upper central incisor (#21).Materials and methodsWe then performed a systematic literature review in December 2022, in accordance with the PRISMA guidelines. The publications, on three databases, dealing with dental treatments on disabled people were selected whether they were clinical studies or case reports.ResultsIn the end, 14 publications were included. Most of the treatments described in the studies (n = 10; 71.43%) concern people aged under 19. The patients present different types of handicaps with various degrees of severity and the oral diseases described are as heterogeneous as the handicaps retrieved.DiscussionIt is therefore difficult to make common treatment recommendations for all these variable profiles and situations. Most of patients in this study are very young, so there is a need for preventive and therapeutic care as earlier as possible, to preserve the vitality of their teeth and dental occlusion.
Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease
Authors: Cebull Hannah L. , Aremu Olukayode O. , Kulkarni Radhika S. , Zhang Samuel X. , Samuels Petronella , Jermy Stephen , Ntusi Ntobeko A.B. , Goergen Craig J. 
Published: July 2023

Abstract
Rheumatic heart disease (RHD) is a neglected tropical disease despite the substantial global health burden. In this study, we aimed to develop a lower cost method of modeling aortic blood flow using subject-specific velocity profiles, aiding our understanding of RHD's consequences on the structure and function of the ascending aorta. Echocardiography and cardiovascular magnetic resonance (CMR) are often used for diagnosis, including valve dysfunction assessments. However, there is a need to further characterize aortic valve lesions to improve treatment options and timing for patients, while using accessible and affordable imaging strategies. Here, we simulated effects of RHD aortic valve lesions on the aorta using computational fluid dynamics (CFD). We hypothesized that inlet velocity distribution and wall shear stress (WSS) will differ between RHD and non-RHD individuals, as well as between subject-specific and standard Womersley velocity profiles. Phase-contrast CMR data from South Africa of six RHD subjects with aortic stenosis and/or regurgitation and six matched controls were used to estimate subject-specific velocity inlet profiles and the mean velocity for Womersley profiles. Our findings were twofold. First, we found WSS in subject-specific RHD was significantly higher (p &lt; 0.05) than control subject simulations, while Womersley simulation groups did not differ. Second, evaluating spatial velocity differences (ΔSV) between simulation types revealed that simulations of RHD had significantly higher ΔSV than non-RHD (p &lt; 0.05), these results highlight the need for implementing subject-specific input into RHD CFD, which we demonstrate how to accomplish through accessible methods.
How Diverse Initial Samples Help and Hurt Bayesian Optimizers
Authors: Kamrah Eesh , Ghoreishi Seyede Fatemeh , Ding Zijian “Jason” , Chan Joel , Fuge Mark 
Published: July 2023

Abstract
Design researchers have struggled to produce quantitative predictions for exactly why and when diversity might help or hinder design search efforts. This paper addresses that problem by studying one ubiquitously used search strategy—Bayesian optimization (BO)—on a 2D test problem with modifiable convexity and difficulty. Specifically, we test how providing diverse versus non-diverse initial samples to BO affects its performance during search and introduce a fast ranked-determinantal point process method for computing diverse sets, which we need to detect sets of highly diverse or non-diverse initial samples. We initially found, to our surprise, that diversity did not appear to affect BO, neither helping nor hurting the optimizer’s convergence. However, follow-on experiments illuminated a key trade-off. Non-diverse initial samples hastened posterior convergence for the underlying model hyper-parameters—a model building advantage. In contrast, diverse initial samples accelerated exploring the function itself—a space exploration advantage. Both advantages help BO, but in different ways, and the initial sample diversity directly modulates how BO trades those advantages. Indeed, we show that fixing the BO hyper-parameters removes the model building advantage, causing diverse initial samples to always outperform models trained with non-diverse samples. These findings shed light on why, at least for BO-type optimizers, the use of diversity has mixed effects and cautions against the ubiquitous use of space-filling initializations in BO. To the extent that humans use explore-exploit search strategies similar to BO, our results provide a testable conjecture for why and when diversity may affect human-subject or design team experiments.
Ka mua, ka muri—Walking backwards into the future
Authors: Lewis Lashana , Walker Shayne , King Paula Toko , Mackay Hunia Te Urukaiata , Talamaivao Natalie , Anderson Daniel , Kemp Susan P 
Published: July 2023

INTRODUCTION: Spurred by critical reviews of Oranga Tamariki–Ministry for Children, Aotearoa New Zealand’s statutory child protection agency, and growing calls for services delivered “by Māori, for Māori, with Māori”, the New Zealand government is taking significant steps toward devolving responsibility for supporting the wellbeing of tamariki, rangatahi, and whanau Māori from the Crown to Iwi and Māori social service providers. Frequently overlooked in discussions of Crown–Māori partnerships are community-based Māta Waka (pan-tribal) organisations, which provide a range of much-needed services to tamariki, rangatahi and whānau Māori who are not mana whenua. The purpose of this Kaupapa Māori research was to examine the expectations that kaimahi working for a Māta Waka Kaupapa Māori service provider have of other organisations that: 1) partner with tamariki, rangatahi and whānau Māori; and, 2) partner with Māta Waka.
APPROACH: Drawing on findings from wānanga with kaimahi, this article illuminates the principles and values that guide their practice, using these as a foundation for exploring the complexities, challenges, and opportunities inherent in building effective partnerships with statutory child protection services on behalf of tamariki, rangatahi and whānau Māori across differences in mandate, power, world views, and guiding frameworks or tikanga Māori.
IMPLICATIONS: The study findings have implications for current Crown–Māori partnership efforts and, by extension, for the wellbeing of tamariki, rangatahi, and whānau Māori.
Congenital CMV associated with diaphragm dysfunction: a rare cause of tachypnoea
Authors: Carter Rebecca , Yakir Maayan , Ryu Julie , Weiss Katherine 
Published: July 2023

A late preterm infant with intrauterine growth restriction developed respiratory distress, tachypnoea and hypoxia after birth, requiring supplemental oxygen. Chest radiographs demonstrated persistent elevation of the right hemidiaphragm. Chest ultrasound initially demonstrated symmetrical bilateral diaphragm motion, but subsequent ultrasounds showed asymmetrical excursion with weaker movement of the right hemidiaphragm. Placental pathology demonstrated chronic infectious villitis secondary to cytomegalovirus (CMV), and subsequent CMV testing on the infant was positive. The infant was microcephalic and head imaging revealed intracranial calcifications, consistent with congenital CMV infection.CMV is the most common congenital infection and has a wide array of clinical manifestations. This report highlights the rarely described association between congenital CMV infection and respiratory distress due to underlying diaphragm dysfunction. In neonates with respiratory distress and features of congenital CMV infection, clinicians should have a high index of suspicion for diaphragm dysfunction.
emgr
– EMpirical GRamian Framework Version 5.99
Authors: Himpe Christian 
Published: July 2023

Version 5.99 of the empirical Gramian framework –
emgr
– completes a development cycle which focused on parametric model order reduction of gas network models while preserving compatibility to the previous development for the application of combined state and parameter reduction for neuroscience network models. Second, new features concerning empirical Gramian types, perturbation design, and trajectory post-processing, as well as a Python version in addition to the default MATLAB / Octave implementation, have been added. This work summarizes these changes, particularly since
emgr
version 5.4, see
Himpe
, 2018 [Algorithms 11(7): 91], and gives recent as well as future applications, such as parameter identification in systems biology, based on the current feature set.
Diagnosing Seasonal Forecast Skill of the Indian Ocean Dipole Mode Using Model Analogs
Authors: Wu Yanling , Tang Youmin 
Published: July 2023

Abstract
A retrospective tropical Indian Ocean dipole mode (IOD) hindcast for 1958–2014 was conducted using 20 models from the sixth phase of the Coupled Model Intercomparison Project (CMIP6), with a model-based analog forecast (MAF) method. In the MAF approach, forecast ensembles are extracted from preexisting model simulations by finding the states that initially best match an observed anomaly and tracking their subsequent evolution, with no additional model integrations. By optimizing the key factors in the MAF method, we suggest that the optimal domain for the analog criteria should be concentrated in the tropical Indian Ocean region for IOD predictions. Including external forcing trends improves the skills of the east and west poles of the IOD, but not the IOD prediction itself. The MAF IOD prediction showed comparable skills to the assimilation-initialized hindcast, with skillful predictions corresponding to a 4- and 3-month lead, respectively. The IOD forecast skill had significant decadal variations during the 55-yr period, with low skill after the early 2000s and before 1985 and high skill during 1985–2000. This work offers a computational efficient and practical approach for seasonal prediction of the tropical Indian Ocean sea surface temperature.
Potential future direction of measurable residual disease evaluation in multiple myeloma
Authors: Mohty Mohamad , Avet-Loiseau Hervé , Malard Florent , Harousseau Jean-Luc 
Published: July 2023

Abstract
Multiple myeloma remains an incurable disease plagued by high relapse rates. Deeper and more sustainable responses, however, have been consistently shown to improve outcomes and could eventually pave the way to achieving a cure. Our understanding of disease response has surpassed complete response (CR), because the current definitions are suboptimal, and the treatment goal should aim even beyond stringent CR, toward molecular and flow CR, that is, measurable residual disease (MRD) negativity. It has been more than 20 years since the discrepancy in the outcome between patients in CR with and without MRD has been demonstrated, and the field has come a long way from multiparameter flow cytometry to next-generation flow and next-generation sequencing, able to detect up to a limit of detection of a single myeloma cell from 1 million healthy counterparts. This review aims to summarize the current available data regarding MRD but also its potential future use as a coprimary outcome both in clinical and trial settings as a survival surrogate as well as its use to evaluate treatment efficacy and for adaptive response-based and early-rescue therapy. Furthermore, we discuss whether these concepts are applicable in different settings (eg, newly diagnosed and relapsed/refractory myeloma, patients who are eligible and ineligible for tansplant, and standard- and high-risk disease).
Mini review: Current status and perspective of S100B protein as a biomarker in daily clinical practice for diagnosis and prognosticating of clinical outcome in patients with neurological diseases with focus on acute brain injury
Authors: Abboud Tammam , Rohde Veit , Mielke Dorothee 
Published: July 2023

AbstractPrognosticating the clinical outcome of neurological diseases is essential to guide treatment and facilitate decision-making. It usually depends on clinical and radiological findings. Biomarkers have been suggested to support this process, as they are deemed objective measures and can express the extent of tissue damage or reflect the degree of inflammation. Some of them are specific, and some are not. Few of them, however, reached the stage of daily application in clinical practice. This mini review covers available applications of the S100B protein in prognosticating clinical outcome in patients with various neurological disorders, particularly in those with traumatic brain injury, spontaneous subarachnoid hemorrhage and ischemic stroke. The aim is to provide an understandable picture of the clinical use of the S100B protein and give a brief overview of the current limitations that require future solutions.