bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and radiographic outcomes of zirconia dental implants—A systematic review and meta‐analysis
Authors: Roehling S. , Gahlert M. , Bacevic M. , Woelfler H. , Laleman I. 
Published: September 2023

AbstractObjectivesFor the present review, the following focused question was addressed: In patients with root‐analog dental implants, what is the effect of implants made of other materials than titanium (alloy) on implant survival, marginal bone loss (MBL), and technical and biological complications after at least 5 years.Materials and MethodsAn electronic (Medline, Embase, Web of Science) search was performed to identify observational clinical studies published from January 2000 investigating a minimum of 20 commercially available zirconia implants with a mean follow‐up of at least 60 months. Primary outcome was implant survival, secondary outcomes included peri‐implant MBL, probing depths (PDs), and technical and biological complications. Meta‐analyses were performed to evaluate implant survival, MBL, and PD.ResultsFrom 5129 titles, 580 abstracts were selected, and 111 full‐text articles were screened. Finally, 4 prospective and 2 retrospective observational clinical cohort studies were included for data extraction. Meta‐analyses estimated after 5 years of loading mean values of 97.2% (95% CI 94.7–99.1) for survival (277 implants, 221 patients), 1.1 mm (95% CI: 0.9–1.3) for MBL (229 implants, 173 patients), and 3.0 mm (95% CI 2.5–3.4) for PDs (231 implants, 175 patients).ConclusionsAfter 5 years, commercially available zirconia implants showed reliable clinical performance based on survival rates, MBL, and PD values. However, more well‐designed prospective clinical studies and randomized clinical trials investigating titanium and zirconia implants are needed to confirm the presently evaluated promising outcomes.
Influence of buccal bone wall thickness on the peri‐implant hard and soft tissue dimensional changes: A systematic review
Authors: Monje Alberto , Roccuzzo Andrea , Buser Daniel , Wang Hom‐Lay 
Published: September 2023

AbstractBackgroundThe significance on the association between the peri‐implant bucco‐lingual dimension (BLD) at the stage of implant placement and the occurrence of biological and esthetic complications is yet unknown.Material and methodsSystematic screening of electronic sources was carried out to identify clinical and preclinical studies reporting on the baseline BLD and/or buccal bone thickness (BBT) values. A secondary objective was to assess the effect of simultaneous grafting at sites with deficient or no buccal bone wall (BBW) at baseline. The primary outcome variables were BBT, BLD, and buccal vertical bone loss (VBL) at re‐evaluation. Moreover, radiographic, clinical, and patient‐reported outcome measures (PROMs) were evaluated.ResultsOverall, 12 clinical and four preclinical studies met the inclusion criteria. Inconsistencies were found in defining the critical BBT across the clinical and preclinical data evaluated. The clinical evidence demonstrated that during healing, dimensional changes occur in the alveolar bone and in the BBW that may compromise the integrity of the peri‐implant bone, leading to VBL and mucosal recession (MR), particularly in scenarios exhibiting a thin BBW. The preclinical evidence validated the fact that implants placed in the presence of a thin BBW, are more prone to exhibit major dimensional changes and VBL. Moreover, the clinical data supported that, in scenarios where dehiscence‐type defects occur and are left for spontaneous healing, greater VBL and MR together with the occurrence of biologic complications are expected. Furthermore, the augmentation of dehiscence‐type defects is associated with hard and soft tissue stability. PROMs were not reported.ConclusionsDimensional changes occur as result of implant placement in healed ridges that may lead to instability of the peri‐implant hard and soft tissues. Sites presenting a thin BBW are more prone to exhibit major changes that may compromise the integrity of the buccal bone and may lead to biologic and esthetic complications.
Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis
Authors: Saengsiwaritt Wacharapol , Jittikoon Jiraphun , Chaikledkaew Usa , Tawonsawatruk Tulyapruek , Honsawek Sittisak , Udomsinprasert Wanvisa 
Published: September 2023

AbstractAberrant autophagic activity is observed in osteoarthritic joints. Vitamin D was shown to alleviate not only osteoarthritis severity, but also autophagy process. However, the influence of vitamin D on autophagy in knee osteoarthritis (KOA) remains ambiguous. This study aimed to determine the effect of vitamin D2 on serum levels of autophagosome protein LC3A in patients with KOA and whether LC3A levels were correlated with serum 25‐hydroxyvitamin D (25(OH)D) and clinical outcomes of patients with KOA. A total of 165 patients with KOA and 25 healthy controls were recruited. Vitamin D2 (ergocalciferol) was administered to patients with KOA at a weekly dosage of 40,000 IU. Serum LC3A, knee pain and functional scores, muscle strength, physical performance, and biochemical parameters were examined before and after 6 months of vitamin D2 supplementation. Serum LC3A levels were significantly higher in patients with KOA than healthy controls. In patients with KOA, vitamin D2 supplementation significantly decreased serum LC3A levels. Furthermore, baseline levels of serum LC3A were significantly associated with radiographic severity, pain and functional scores, total cholesterol, hs‐CRP, IL‐6, protein carbonyl, and serum 25(OH)D. After adjusting for established confounders, independent relationships among serum LC3A and radiographic severity, pain and functional scores, total cholesterol, hs‐CRP, IL‐6, protein carbonyl, and serum 25(OH)D were also observed. Vitamin D2 supplementation was shown to not only decrease serum levels of LC3A, inflammatory markers, as well as oxidative stress, but also improve muscle strength and physical performance in patients with KOA.
The presence of busulfan metabolites and pharmacometabolomics in plasma drawn immediately before allograft infusion in hematopoietic cell transplant recipients
Authors: McCune Jeannine S. , Navarro Sandi L. , Risler Linda J. , Phillips Brian R. , Ren Suping , Schoch H. Gary , Baker K. Scott 
Published: September 2023

AbstractBusulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ‐glutamyldehydroalanylglycine, which is too unstable to be quantitated in vivo. We sought to evaluate if pre‐graft (i.e., immediately before allograft infusion) concentrations of busulfan metabolites' and of endogenous metabolomic compounds (EMCs) representing the glutathione pathway were associated with clinical outcomes in hematopoietic cell transplant (HCT) recipients receiving busulfan. The clinical outcomes evaluated were relapse, acute graft versus host disease (GVHD), chronic GVHD, non‐relapse mortality, and neutrophil nadir. In pre‐graft samples obtained from patients immediately before allograft infusion, our objectives were to evaluate for: (1) the presence of busulfan and its metabolites tetrahydrothiophenium ion (THT+), tetrahydrothiophene 1‐oxide, sulfolane, and 3‐hydroxysulfolane (N = 124); (2) EMCs using a global metabolomics assay (N = 77); and (3) the association of the busulfan metabolites and the EMCs with clinical outcomes. In the pre‐graft samples, busulfan and THT+ could not be detected. THT 1‐oxide, sulfolane, and 3‐hydroxysulfolane were quantitated in 9.6%, 26%, and 58% of pre‐graft samples; their concentrations were not associated with clinical outcomes. Four pre‐graft EMCs were statistically significantly associated with the neutrophil nadir. The pre‐graft EMCs were not associated with the other clinical outcomes. In conclusion, busulfan's metabolites are present in patients' plasma immediately before allograft infusion; the neutrophil nadir is associated with pre‐graft EMCs. Future research should investigate the association of clinical outcomes with the concentrations of busulfan's metabolites and EMCs in the pre‐graft plasma from allogeneic HCT recipients.
End‐of‐life wishes and care planning for patients with advanced skin cancer
Authors: Volberg Christian , Schrade Severin , Heers Hendrik , Carrasco Anna J. Pedrosa , Morin Astrid , Gschnell Martin 
Published: September 2023

SummaryBackgroundPatients with advanced or metastatic skin cancer have a limited life expectancy and the majority die as a result of the tumor despite modern treatment options. The preferences of these patients concerning care during their last phase of life are currently unknown.Patients and methods150 patients with advanced skin cancer (AJCC/UICC stage III or IV) were interviewed using a structured questionnaire.Results75% of the respondents wished to die in their domestic environment, although a more advanced tumor stage and increased reflection upon end‐of‐life care lead away from this wish. However, only 42% reported having communicated this wish to someone else. 55% of the respondents had completed advance directives, while younger patients did this significantly less often (95% CI: 0.11–0.56; p = 0.001). The majority of patients (62%) would like to have discussions about possibilities for end‐of‐life care with the attending dermato‐oncologist.ConclusionsAlthough the moment of death is unpredictable, early initiation of end‐of‐life advance care planning appears prudent. The attending dermato‐oncologists should take the initiative to raise the subject with their patients during routine control visits. In this context, it may be useful to present available care options to patients and relatives and to design strategies for the event of deteriorating health.
Contrasting long‐term changes in lake trajectories linked to differences in wind‐induced mixing in the Peruvian Andes
Authors: Jones Evan , Michelutti Neal , Grooms Christopher , Tapia Pedro , Smol John P. 
Published: September 2023

Abstract

Historically, many high‐elevation lakes in the tropical Andes have been observed to mix frequently, with rare, brief periods of thermal stratification. As temperatures have risen in the Andes over the past several decades, thermistor data have shown that many lakes are now experiencing longer periods of thermal stratification with resultant ecological restructuring. Palaeolimnological studies from these lakes have recorded striking diatom assemblage shifts, coeval with recent changes in thermal stratification.

Here, we analyse subfossil diatom assemblages from a wind‐sheltered lake, Laguna Yanacocha, in the Peruvian Andes. Thermistors deployed in the lake indicated that Laguna Yanacocha was more strongly thermally stratified and for longer periods than other nearby lakes. We hypothesised that, owing to its sheltered position, this lake is likely to have exhibited enhanced periods of thermal stratification even before the period of recent warming, and that these limnological conditions would be tracked in the subfossil diatom record.

The diatom assemblages from Laguna Yanacocha recorded consistently high abundances of the obligate planktonic taxon Discostella stelligera over the last several centuries. This taxon is known to flourish with warming and has been shown to increase in abundance with the onset of thermally stratified conditions in other Andean waterbodies, as well as lakes globally. The dominance of D. stelligera throughout the entire sediment record suggests a long history of thermal stratification that is likely to be a consequence of the study lake's surrounding topography, which shelters it from wind mixing.

The sub‐fossil assemblage data from Laguna Yanacocha contrasts with assemblages from previously studied wind‐swept lakes in the Andes, which primarily show low abundances of D. stelligera before well‐documented temperature increases. The fossil diatom record from Laguna Yanacocha may provide an indication of how other lakes from the region will respond to warming temperatures and enhanced thermal stratification.
Relational practices for meaningful inclusion in health research: Results of a deliberative dialogue study
Authors: Plamondon Katrina , Banner Davina , Cary Miranda A. , Faulkner Melissa , Gainforth Heather , Ghag Kiranpreet , Hoens Alison , Huisken Anne , Kandola Damanpreet K. , Khan Shaheer , Silva Aline Silveira , Oelke Nelly , Rai Ashmita , Strain Kimberly , Sibley Kathryn M. , Wick Ursula 
Published: September 2023

AbstractIntroductionThe importance of including people affected by research (e.g., community members, citizens or patient partners) is increasingly recognized across the breadth of institutions involved in connecting research with action. Yet, the increasing rhetoric of inclusion remains situated in research systems that tend to reward traditional dissemination and uphold power dynamics in ways that centre particular (privileged) voices over others. In research explicitly interested in doing research with those most affected by the issue or outcomes, research teams need to know how to advance meaningful inclusion. This study focused on listening to voices often excluded from research processes to understand what meaningful inclusion looks and feels like, and asked what contributes to being or feeling tokenized.MethodsIn this deliberative dialogue study, 16 participants with experience of navigating social exclusions and contributing to research activities reflected on what makes for meaningful experiences of inclusion. Using a co‐production approach, with a diversely representative research team of 15 that included patient and community partners, we used critically reflective dialogue to guide an inclusive process to study design and implementation, from conceptualization of research questions through to writing.ResultsWe heard that: research practices, partnerships and systems all contribute to experiences of inclusion or exclusion; the insufficiency or absence of standards for accountability amplifies the experience of exclusion; and inclusive practices require intention, planning, reflection and resources.ConclusionsWe offer evidence‐informed recommendations for the deeply relational work and practices for inclusivity, focused on promising practices for cultivating welcoming systems, spaces and relationships.Patient or Public ContributionThis work reflects a co‐production approach, where people who use and are affected by research results actively partnered in the research process, including study design, data‐generating activities, analysis and interpretation, and writing. Several of these partners are authors of this manuscript.
Experiences of people with long COVID: Symptoms, support strategies and the Long COVID Optimal Health Programme (LC‐OHP)
Authors: Al‐Jabr Hiyam , Thompson David R. , Castle David J. , Ski Chantal F. 
Published: September 2023

AbstractIntroductionLong COVID (LC) is a multisystem illness, with fluctuating symptoms that affect the daily activities of patients. There are still no standardised diagnostic criteria or treatment approaches for managing LC. The LC‐Optimal Health Programme (LC‐OHP) was designed to support the mental wellbeing and physical health of people with LC. Gaining an in‐depth understanding of patients' experiences and support strategies is imperative to identifying appropriate supports to guide them through their recovery. This study aimed to elicit the experiences and perceptions of adults with LC regarding symptoms, support strategies and the LC‐OHP.MethodsAs part of a wider randomised controlled trial of the LC‐OHP, participants in the intervention group had their sessions audio‐recorded. Transcripts were thematically analysed to identify common emergent themes.FindingsThe LC‐OHP was delivered to 26 participants. Data were collected between January 2022 and February 2023. Four main themes emerged: ‘Symptoms and impact of LC’; ‘Other sources of support and perceived challenges’; ‘Strategies to support LC’ and ‘Perceptions of the LC‐OHP’.ConclusionLC experiences were mostly described as fluctuating and burdensome that significantly impacted daily activities, and physical and mental health. The LC‐OHP was perceived as beneficial. Access and experiences of other sources of support were varied. Increasing LC awareness amongst health practitioners and the wider community has the potential to improve the experiences of those affected by LC.Patient or Public ContributionThe LC‐OHP was derived from the OHP. It was adapted to people with LC following consultation with practitioners at an LC clinic. Additionally, the mode and timing of delivering the programme to this population were taken into account for its delivery at the convenience of participating patients. While considering that fatigue and brain fog are amongst the most reported complaints of people with LC, public members with LC were not involved directly in this study; however, feedback obtained from practitioners working with this population was implemented in amending the programme and its delivery. Additionally, feedback from patients with other chronic health conditions who used the OHP in previous studies has been implemented to make the programme more user‐friendly. Moreover, feedback obtained from participants receiving this programme in this study was implanted immediately and shared with other participants. Finally, this study was overviewed by a data management committee that included two public members with LC, who contributed and provided guidance to support this study.
Nest aggregations of wild bees and apoid wasps in urban pavements: A ‘street life’ to be promoted in urban planning
Authors: Noël Grégoire , Van Keymeulen Violette , Barbier Yvan , Smets Sylvie , Van Damme Olivier , Colinet Gilles , Lokatis Sophie , Ruelle Julien , Francis Frédéric 
Published: September 2023

Abstract
In the last 10 years, the interest in nature‐based solutions and ecosystem services like pollination has increased profoundly and with it the need to gather knowledge about wild bees and apoid wasp community dynamics, especially in urban ecosystems. Research on how the urban environment impacts the conditions of nesting sites is relatively scarce. Recent observations in the Brussels‐Capital Region (BCR; Belgium) show that urban pavements can provide alternative nesting opportunities for ground‐nesting Hymenoptera, such as wild bees and apoid wasps.
Here, using a citizen science approach, we investigated the richness of ground‐nesting species living under urban pavements, as well as their preferences for sidewalk characteristics.
A total of 22 species belonging to 10 families of wild bees, digger wasps and their associated cleptoparasites were identified at 89 sites in the BCR (Belgium). Sandstone setts or concrete slabs, with an unbound joint size of around 10 mm, were found to be the best suitable urban pavements for the ground‐nesting species. The soil texture under the pavement contained mainly sandy particles.
We propose management guidelines to support bee and wasp species nesting under urban pavement in highly urbanised areas. Our observations pave the way for further research in the field of urban ecology and highlight the potential of multifunctional pavement designs that promote not only climate adaptation but also biodiversity.
ESG for All? The Impact of ESG Screening on Return, Risk, and Diversification
Authors: Verheyden Tim , Eccles Robert G. , Feiner Andreas 
Published: September 2023

A large body of research has documented a positive relationship between different measures of sustainability—such as indicators of employee satisfaction and effective corporate governance—and corporate financial performance. Nevertheless, many investors still struggle to quantify the value of ESG to investment performance.To address this issue, the authors tested the effects of using different ESG filters on an investable universe that serves as the starting point for a fund manager. In this way, they attempted to determine the extent to which ESG data can add value to any investment approach, regardless of preferences towards sustainable investing.The authors report “an unequivocally positive” contribution to risk‐adjusted returns when using a 10% best‐in‐class ESG screening approach (one that effectively removes companies with the lowest 10% of ESG rankings), both on a global and a developed markets universe. More specifically, as a result of such screening, both the global and developed markets portfolios show higher returns, lower (tail) risk, and no significant reduction of diversification potential despite the reduction in the number of companies. Use of a 25% screening filter was also found to add value, especially by reducing tail risks, but with a larger deviation from the unscreened universe.Overall, then, the authors’ finding is that the incorporation of ESG information contributes to better decision‐making in every investment approach, with the optimal configuration depending on a fund manager's preferences and willingness to deviate from an unscreened benchmark.
Health‐related quality of life in patients with generalized pustular psoriasis: A systematic literature review
Authors: Choon S. E. , De La Cruz C. , Wolf P. , Jha R. K. , Fischer K. I. , Goncalves‐Bradley D. C. , Hepworth T. , Marshall S. R. , Gottlieb A. B. 
Published: September 2023

AbstractGeneralized pustular psoriasis (GPP) is a rare, chronic, neutrophilic inflammatory skin disease characterized by episodes of widespread eruption of sterile, macroscopic pustules that can be accompanied by systemic inflammation and symptoms. A systematic literature review and narrative synthesis were conducted to determine the impact of GPP on patients' health‐related quality of life (HRQoL) and patient‐reported severity of symptoms and to compare its impact to patients with plaque psoriasis (plaque PsO). Searches were undertaken in Embase, MEDLINE and the Cochrane Library from 1 January 2002 to 15 September 2022. Screening was carried out by two reviewers independently. Outcome measures included generic (e.g. EQ‐5D, SF‐36) and dermatology‐specific (e.g. DLQI) clinical outcome assessments, and other relevant patient‐reported outcome measures (PROMs) (e.g. severity of pain measured by a numerical rating scale). Overall, 20 studies were found to be eligible for inclusion, of which seven also had data for plaque PsO. The DLQI was the most frequently reported outcome measure (16 out of 20 studies). When reported, mean DLQI (SD) scores varied from 5.7 (1.2) to 15.8 (9.6) across the studies, indicating a moderate to very large effect on HRQoL; the wide range of scores and large SDs were explained by the small population sizes (n ≤ 12 for all studies except two). Similar ranges and large SDs were also observed for other measures within individual studies. However, in general, people with GPP reported a greater impact of their skin condition on HRQoL, when compared to people with plaque PsO (i.e. higher DLQI scores) and higher severity for itch, pain and fatigue. This systematic review highlighted the need for studies with a larger population size, a better understanding of the impact of cutaneous and extracutaneous symptoms and comorbidities on HRQoL during and between GPP flares, and outcome measures specifically tailored to the unique symptoms and the natural course/history of GPP.