bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic changes in polioviruses identified by environmental surveillance in Guangzhou, 2009–2021
Authors: Chen Meizhong , Zhang Yong , Zhang Wei , Huang Shufen , Zhu Shuangli , Li Caixia , Guo Xue , Zeng Hanri , Fang Ling , Ke Bixia , Li Hui , Yoshida Hiromu , Xu Wenbo , Ke Changwen , Deng Xiaoling , Zheng Huanying 
Published: March 2023

AbstractPolio cases can be missed by acute flaccid paralysis (AFP) case surveillance alone, emphasizing the importance of environmental surveillance (ES). In this study, to investigate the serotype distribution and epidemiological trends of poliovirus (PV), we characterized PV isolated from domestic sewage in Guangzhou City, Guangdong Province, China from 2009 to 2021. A total of 624 sewage samples were collected from the Liede Sewage Treatment Plant, and the positive rates of PV and non‐polio enteroviruses were 66.67% (416/624) and 78.37% (489/624), respectively. After sewage sample treatment, each sewage sample was inoculated in six replicate tubes of three cell lines, and 3370 viruses were isolated during the 13‐year surveillance period. Among these, 1086 isolates were identified as PV, including type 1 PV (21.36%), type 2 PV (29.19%), and type 3 PV (49.48%). Based on VP1 sequences, 1057 strains were identified as Sabin‐like, 21 strains were high‐mutant vaccines, and eight strains were vaccine‐derived poliovirus (VDPV). The numbers and serotypes of PV isolates in sewage were influenced by the vaccine switch strategy. After type 2 OPV was removed from the trivalent oral PV (OPV) vaccine and a bivalent OPV (bOPV) was adopted in May 2016, the last type 2 PV strain was isolated from sewage, with no detection thereafter. Type 3 PV isolates increased significantly and became the dominant serotype. Before and after the second vaccine switch in January 2020, that is, from the first dose of IPV and second–fourth doses of bOPV to the first two doses of IPV and third–fourth doses of bOPV, there was also a statistical difference in PV positivity rates in sewage samples. Seven type 2 VDPVs and one type 3 VDPV were identified in sewage samples in 2009–2021, and phylogenetic analysis indicated that all VDPVs isolated from ES in Guangdong are newly discovered VDPVs, different from VDPV previously discovered in China, and were classified as ambiguous VDPV. It is noteworthy that no VDPV cases were reported in AFP case surveillance in the same period. In conclusion, continued PV ES in Guangzhou since April 2008 has been a useful supplement to AFP case surveillance, providing an important basis for evaluating the effectiveness of vaccine immunization strategies. ES improves early detection, prevention, and control; accordingly, this strategy can curb the circulation of VDPVs and provide a strong laboratory basis for maintaining a polio‐free status.
Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: Is two better than one? Real‐world experience from a tertiary care hospital
Authors: Margonato Davide , Preda Alberto , Ingallina Giacomo , Rizza Vincenzo , Fierro Nicolai , Radinovic Andrea , Ancona Francesco , Patti Giuseppe , Agricola Eustachio , Bella Paolo Della , Mazzone Patrizio 
Published: March 2023

AbstractBackgroundThe role of left atrial appendage occlusion (LAAO) for atrial fibrillation patients that during oral anticoagulant therapy (OAC) suffer from ischemic events or present LAA sludge, and the best postinterventional anticoagulant regimen, need to be defined. We present our experience with a hybrid approach of LAAO+ lifelong OAC therapy in this cohort of patients.MethodsOut of 425 patients treated with LAAO, 102 underwent LAAO because, despite OAC, suffered from ischemic events or presented with LAA sludge. Patients without high bleeding risk were discharged with the aim of maintaining lifelong OAC. This cohort was then matched to a population who underwent LAAO in primary ischemic events prevention. The primary endpoint was the composite of all‐cause death and major adverse cardiovascular events consisting of ischemic stroke, systemic embolism (SE), and major bleeding.ResultsProcedural success was 98%, and 70% of patients were discharged with anticoagulant therapy. After a median follow‐up of 47.2 months, the primary endpoint occurred in 27 patients (26%). At multivariate analyses, coronary artery disease (OR 5.1, CI 1.89–14.27, p = .003) and OAC at discharge (OR 0.29, CI 0.11–0.80, p = .017) were associated with the primary endpoint. After propensity score matching, no significant difference was found in the survival free from the primary endpoint according to the indication for LAAO (p = .19).ConclusionsIn this high‐ischemic risk cohort, LAAO + OAC seem a long‐term safe and effective therapeutical approach, with no difference in the survival free from the primary endpoint according to the indication for LAAO in a matched cohort.
Can a familiar gender stereotype create a not‐so‐familiar benefit for women? Evidence of gendered differences in ascribed stereotypes and effects of team member adaptivity on performance evaluations
Authors: Carpini Joseph A. , Luksyte Aleksandra , Parker Sharon K. , Collins Catherine G. 
Published: March 2023

SummaryOur research examines the differential effects of stereotypically feminine work behavior—team member adaptivity—on performance evaluations. Team member adaptivity requires being accommodating to changing relational and situational demands to achieve interdependent work goals. As such, women who engage in team member adaptivity will be recognized and rewarded more in their performance evaluations compared to men. We tested our model across three studies. As hypothesized, the results of Experimental Study 1 (N = 600) demonstrated team member adaptivity is subject to a gendered stereotype and ascribed to women more so than to men. Building on this finding, Field Study 2 (N = 96) demonstrated that team member adaptivity was positively related to performance evaluations for women but not for men. Study 3 used multi‐source dyadic data obtained from managers and their supervisors (N = 141) and demonstrated that women who engage in team member adaptivity receive more favorable performance evaluations than their male counterparts. Together, these studies demonstrated the benefits of team member adaptivity for women more so than for men. This research extends our understanding of social role theory as well as the outcomes of adaptive performance while also offering several avenues for future scholarship with the potential to address ongoing gender inequities in the workplace.
Could foliar applications of methyl jasmonate and methyl jasmonate + urea improve must grape aroma composition?
Authors: Garde‐Cerdán Teresa , González‐Lázaro Miriam , Marín‐San Román Sandra , Sáenz de Urturi Itziar , Murillo‐Peña Rebeca , Rubio‐Bretón Pilar , Pérez‐Álvarez Eva Pilar 
Published: March 2023

AbstractBACKGROUNDGrape aromas are formed by a great number of volatile compounds. Methyl jasmonate (MeJ) and urea (Ur) foliar applications have been studied to improve grape quality, but their combined application has never been studied.RESULTSIn both seasons, MeJ application enhanced terpenoids and C6 compounds synthesis, though decreased alcohols content. Moreover, MeJ + Ur treatment reduced benzenoids and alcohols and did not affect C13‐norisoprenoids content. However, there was no clear effect of these treatments on the rest of the volatile compounds. Multifactorial analysis showed a season effect on all volatile compounds, except terpenoids. Discriminant analysis showed a good separation among samples under treatment criterion. The great effect of MeJ treatment on terpenoids was probably due to this elicitor influencing their biosynthesis.CONCLUSIONSeason has a strong influence on grapes aromatic composition since it affects all volatile compound families except terpenoids. MeJ foliar application enhanced terpenoids, C13‐norisoprenoids and C6 compounds synthesis, whereas decreased alcohols content; however, MeJ + Ur foliar treatment did not affect C13‐norisoprenoids and C6 compounds, and decreased benzenoids and alcohols grape compounds. Therefore, no synergistic effect was observed between Ur and MeJ on grape volatile compounds biosynthesis. Foliar application of MeJ seems to be sufficient to improve the aromatic quality of grapes. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Care at high‐volume centers is associated with improved outcomes for patients with pancreatic neuroendocrine tumors: A population‐level analysis
Authors: Patel Ranish K. , Sutton Thomas L. , Schwantes Issac R. , Behrens Shay , Pommier Rodney F. , Rocha Flavio G. , Sheppard Brett C. 
Published: March 2023

AbstractBackground and ObjectivesPrimary resection and debulking of liver metastases have been associated with improved survival in pancreatic neuroendocrine tumors (PNETs). The treatment patterns and outcomes differences between low‐volume (LV) institutions and high‐volume (HV) institutions remains unstudied.MethodsA statewide cancer registry was queried for patients with nonfunctional PNET from 1997 to 2018. LV institutions were defined as treating <5 newly diagnosed patients with PNET per year, while HV institutions treated ≥5.ResultsWe identified 647 patients: 393 with locoregional (n = 236 HV care, n = 157 LV care) and 254 with metastatic disease (n = 116 HV care, n = 138 LV care). Patients with HV care had improved disease‐specific survival (DSS) compared to patients with LV care for both locoregional (median 63 vs. 32 months, p < 0.001) and metastatic disease (median 25 vs. 12 months, p < 0.001). In patients with metastatic disease, primary resection (hazard ratio [HR]: 0.55, p = 0.003) and HV institution (HR: 0.63, p = 0.002) were independently associated with improved DSS. Furthermore, diagnosis at a HV center was independently associated with higher odds of receiving primary site surgery (odds ratio [OR]: 2.59, p = 0.01) and metastasectomy (OR: 2.51, p = 0.03).ConclusionsCare at HV centers is associated with improved DSS in PNET. We recommend referral of all patients with PNETs to HV centers.
Are the MIA and MSKCC nomograms useful in selecting patients with melanoma for sentinel lymph node biopsy?
Authors: Hosein Sharif , Drebin Harrison M. , Kurtansky Nicholas R. , Olofsson Bagge Roger , Coit Daniel G. , Bartlett Edmund K. , Marchetti Michael A. 
Published: March 2023

AbstractBackground and MethodsThe Melanoma Institute of Australia (MIA) and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms were developed to help guide sentinel lymph node biopsy (SLNB) decisions. Although statistically validated, whether these prediction models provide clinical benefit at National Comprehensive Cancer Network guideline‐endorsed thresholds is unknown. We conducted a net benefit analysis to quantify the clinical utility of these nomograms at risk thresholds of 5%–10% compared to the alternative strategy of biopsying all patients. External validation data for MIA and MSKCC nomograms were extracted from respective published studies.ResultsThe MIA nomogram provided added net benefit at a risk threshold of 9% but net harm at 5%–8% and 10%. The MSKCC nomogram provided added net benefit at risk thresholds of 5% and 9%–10% but net harm at 6%–8%. When present, the magnitude of net benefit was small (1–3 net avoidable biopsies per 100 patients).ConclusionNeither model consistently provided added net benefit compared to performing SLNB for all patients.DiscussionBased on published data, use of the MIA or MSKCC nomograms as decision‐making tools for SLNB at risk thresholds of 5%–10% does not clearly provide clinical benefit to patients.
The inaccuracies of gastric adenocarcinoma clinical staging and its predictive factors
Authors: Janczewski Lauren M. , Shah Dhavan , Wells Amy , Bentrem David J. , Abad John D. , Chawla Akhil 
Published: March 2023

AbstractIntroductionAccurate clinical staging (CS) of gastric adenocarcinoma is important to guide treatment planning. Our objectives were to (1) assess clinical to pathologic stage migration patterns for patients with gastric adenocarcinoma, (2) identify factors associated with inaccurate CS, and (3) evaluate the association of understaging with survival.MethodsThe National Cancer Database was queried for patients who underwent upfront resection for stage I–III gastric adenocarcinoma. Multivariable logistic regression was used to detect factors associated with inaccurate understaging. Kaplan–Meier analyses and cox proportional hazards regression were performed to assess overall survival (OS) for patients with inaccurate CS.ResultsOf 14 425 analyzed patients, 5781 (40.1%) patients were inaccurately staged. Factors associated with understaging included treatment at a Comprehensive Community Cancer Program, presence of lymphovascular invasion, moderate to poor differentiation, large tumor size, and T2 disease. Based on overall CS, median OS was 51.0 months for accurately staged patients and 29.5 months for understaged patients (<0.001).ConclusionClinical T‐category, large tumor size, and worse histologic features lead to inaccurate CS for gastric adenocarcinoma, impacting OS. Improvements to staging parameters and diagnostic modalities focusing on these factors may improve prognostication.
Headstarting turtles to larger body sizes for multiple years increases survivorship but with diminishing returns
Authors: Mullin Damien I. , White Rachel C. , Mullen Jory L. , Lentini Andrew M. , Brooks Ronald J. , Litzgus Jacqueline D. 
Published: March 2023

AbstractHeadstarting is a conservation tool that assumes raising turtles in protected ex situ environments to larger body sizes, then releasing them back into the wild, increases their survivorship compared to wild, non‐headstarted turtles. Our goal was to quantitatively test this fundamental assumption by comparing somatic growth and survivorship among 3 age classes of headstarted juvenile wood turtles (Glyptemys insculpta) monitored for 3 years (2016–2018) in Ontario, Canada. Our age classes were turtles headstarted for 2 years (n = 15), turtles headstarted for 1 year (n = 30), and turtles incubated and hatched ex situ, then released (i.e., no headstarting; hatchlings, n = 30). Both age classes of headstarted turtles were radio‐tracked for 1 year after release. We released hatchlings in August and radio‐tracked them for 1 month. All cohorts exhibited positive somatic growth after release. One‐month post‐release survival of hatchlings was 70%. Turtles headstarted for 2 years had slightly higher 1‐year post‐release survivorship (67%) than turtles headstarted for 1 year (47%), but there was little to no evidence for a difference (P = 0.17). Modeling these survivorship results with real‐life constraints of only 100 hatchlings available for headstarting each year (biological constraint from source population), and a 100‐turtle capacity in our headstarting facility (economic constraint), projected similar population growth in 2‐year and 1‐year headstarting programs. When removing the 100‐turtle facility limit, the 2‐year program projected higher population growth but required space for 200 turtles in the headstarting facility, which may not be feasible for many programs. Our results support the fundamental assumption that headstarting increases survivorship, but we observed diminishing returns if headstarting was increased for longer than 1 year. Given the growing number of turtle headstarting projects globally, our study provides data that can aid in establishing cost‐ and resource‐effective best practices.
Photonic Bandgap Fiber Microlaser with Dual‐Band Emission for Integrated Optical Tagging and Sensing
Authors: Wang Yanqiong , Gong Chaoyang , Yang Xi , Zhu Tao , Zhang Ke , Rao Yun‐Jiang , Wei Lei , Gong Yuan 
Published: March 2023

AbstractLasers are emerging as novel photonic tags for single‐cell labeling, anticounterfeiting, and encryption technology due to their narrow linewidth, high spectral multiplexing capacity, and superior stimuli‐responsiveness. These laser‐encoded photonic tags mostly distinguish the heterogeneity but do not yet provide both tagging and sensing of biosamples, which is highly desirable for disease screening. Here, a photonic bandgap (PBG) fiber microlaser that works as a 2D tag and an immunosensor is developed. The tubular PBG structure allows strong light–matter interaction and supports dual‐band lasing in the same optical fiber, enabling massive biosample tagging and sensitive biodetection. By encoding the random resonant peaks in the short‐wave band and multiplexing in the spatial domain, a 2D laser tag is generated with a large encoding capacity (>28500). Immunosensing of microalbumin is realized by using the periodic resonant peaks in the long‐wave band, and a limit of detection of 0.06 ng µL−1is achieved. This work is inspiring for the development of high‐performance, multifunctional integrated devices for disease screening.
Smoothing Energy Transfer Enabling Efficient Large‐Area Quasi‐2D Perovskite Light‐Emitting Diodes
Authors: Cai Lei , Chen Jiangyu , Zang Jiaqing , Zhou Jungui , Zou Yatao , Bai Guilin , Chen Zhewei , Song Tao , Wang Chuan‐Kui , Sun Baoquan 
Published: March 2023

AbstractElectroluminescence (EL) efficiency of perovskite light‐emitting diodes (PeLEDs) based on a few square millimeters has improved significantly in recent years. Nevertheless, the EL efficiency of PeLEDs would plunge once the active area is enlarged from a millimeter to even a subcentimeter due to the unsmooth energy transfer process among the edge region with numerous nonradiative recombination centers. Herein, an intriguing strategy is developed to realize high‐quality quasi‐2D perovskite thin film via tuning perovskite precursor rheological properties as well as modulating the substrate surface tension. The perovskite crystallization process is retarded by incorporating a strong chelating ligand into its precursor. Hydroxylamine‐O‐sulfonic acid, containing a sulfonic acid group and an amino group, acts as a strong chelating agent with lead ions (Pb2+), which exhibit great synergistic potential in defect passivation and crystallization modulation. As a result, a large‐area (25 cm2) quasi‐2D PeLED achieves an external quantum efficiency of 20.7% with uniform emitting characteristics, a record value among analogous same‐size PeLEDs. The work may pave the way to realize high‐performance large‐area perovskite optoelectronic devices.
Fabrication, Optical Property, and White LED Application of Novel Lanthanide‐Based Family Cs2NaLnX6 (X = Cl, Br, I) Perovskite Nanomaterials
Authors: Sun Liheng , Dong Biao , Sun Jiao , Wang Yue , Sun Rui , Hu Songtao , Zhou Bingshuai , Xu Wen , Bai Xue , Xu Lin , Zhou Donglei , Song Hongwei 
Published: March 2023

AbstractLead free double perovskites are highly promising optoelectronic materials, but most of them suffer from low photoluminescence quantum yield (PLQY) and poor stability. Herein, a series of lanthanide elements are used to prepare the lead free double perovskite Cs2NaLnX6 (X = Cl, Br, I) nanocrystals (NCs), acting as both the main structural ions and the 4f–4f emission centers. The mechanisms for the broadband emission of Cs2NaLnX6 NCs host are carefully studied based on various spectral results combining ultrafast dynamics detection and first‐principles calculation. The broadband emission of the Cs2NaLnX6 NCs originates from the self‐trapped exciton. The Cs2NaLnX6 NCs show remarkable water stability for more than eight months and favorable temperature and light irradiation stability (500 h). The PLQY for these materials is much higher than most of double perovskite materials, especially for Cs2NaEuCl6, which can approach to 70%. The white light emission from a single host material Cs2NaEuTbCl6 (Tb:Eu = 25:1) is obtained and applied to a light‐emitting diode device, with a good CIE (Commission International de L'Eclairage) coordinate of (0.334, 0.326) and color rendering index of 91.2. Overall, the characteristics of lanthanide ions endow the super performance of Cs2NaLnX6 NCs, which is obviously an important choice for future optoelectronic devices.
In Vitro Proof of Concept of a First‐Generation Growth‐Accommodating Heart Valved Conduit for Pediatric Use
Authors: Li Richard L. , Sun Mingze , Russ Jonathan B. , Pousse Pierre‐Louis , Kossar Alexander P. , Gibson Isabel , Paschalides Costas , Herschman Abigail R. , Abyaneh Maryam H. , Ferrari Giovanni , Bacha Emile , Waisman Haim , Vedula Vijay , Kysar Jeffrey W. , Kalfa David 
Published: March 2023

AbstractCurrently available heart valve prostheses have no growth potential, requiring children with heart valve diseases to endure multiple valve replacement surgeries with compounding risks. This study demonstrates the in vitro proof of concept of a biostable polymeric trileaflet valved conduit designed for surgical implantation and subsequent expansion via transcatheter balloon dilation to accommodate the growth of pediatric patients and delay or avoid repeated open‐heart surgeries. The valved conduit is formed via dip molding using a polydimethylsiloxane‐based polyurethane, a biocompatible material shown here to be capable of permanent stretching under mechanical loading. The valve leaflets are designed with an increased coaptation area to preserve valve competence at expanded diameters. Four 22 mm diameter valved conduits are tested in vitro for hydrodynamics, balloon dilated to new permanent diameters of 23.26 ± 0.38 mm, and then tested again. Upon further dilation, two valved conduits sustain leaflet tears, while the two surviving devices reach final diameters of 24.38 ± 0.19 mm. After each successful dilation, the valved conduits show increased effective orifice areas and decreased transvalvular pressure differentials while maintaining low regurgitation. These results demonstrate concept feasibility and motivate further development of a polymeric balloon‐expandable device to replace valves in children and avoid reoperations.
Mesoporous Natural Fiber Welded Cellulose Containing Silver Nanoparticles as a Recyclable Heterogeneous Catalyst
Authors: Larm Nathaniel E. , Gulbrandson Anders J. , Stachurski Christopher D. , Chase Mary A. , Trulove Paul C. , Durkin David P. 
Published: March 2023

AbstractSilver nanoparticles (AgNPs) are presented within mesoporous natural fiber welded (NFW) cellulose and demonstrated as robust catalysts to reduce 4‐nitrophenol using sodium borohydride. Growing AgNPs this way enables their retention within a nonderivatized, mesoporous, all‐cellulose NFW composite. At an AgNP loading of 1.0 wt%, no leaching is observed during rinsing with polar and nonpolar solvents or any of 12 catalyst cycles and the cloth is easily retrievable and reusable. Comparatively, a 1.0 wt% AgNP loading on non‐NFW cotton thread loses ≈95% of the starting Ag under similar conditions. Only at higher loadings is a very slow leaching observed in the NFW composite (<10% Ag loss). With a turnover frequency of 0.9 h–1 (as compared to 2.2 h–1 for the non‐NFW cotton thread), the catalytic activity suffers only minor impedance from the NFW structure while affording significant promise in future applications for leach‐resistant nonderivatized cotton (e.g., TiO2 or photonic nanomaterials). Finally, it is shown that combustion of AgNPs‐NFW composites creates Ag residues distinct from materials produced via combustion of AgNPs on non‐NFW cotton. While the residues produced comprise Ag and residual carbon, this method is viable for producing metal “sponges” from monometallic and bimetallic NPs on mesoporous cellulose.