bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel set of Austrian reference unit costs for comprehensive societal perspectives consistent with latest European costing methods for economic evaluations
Authors: Berger Michael , Mayer Susanne , Simon Judit 
Published: December 2022

SummaryDecision making in public health often happens against the background of scarce resources. The systematic use of economic evaluations can be a main enabler in the alignment of public health goals with budgetary constraints. However, the lack of standardized methodology in terms of costing method and perspective are a critical barrier to the implementation of economic evaluations and the international comparability of results. We present a novel set of 22 reference unit costs (RUCs) optimized for cross-sectoral economic evaluations in Austria suitable for international comparability calculated using the standardized PECUNIA RUC Template. The common framework for costing and reporting, as well as the easy availability of the RUCs will reduce the burden on researchers and policy makers in future economic evaluations. The higher quality, accuracy, transparency and availability of economic evidence for policy design will help to improve the efficiency of public health-relevant healthcare decisions and make it easier for policy makers to bring funding arrangements and decision making across multiple sectors in line with Health-in-All-Policies goals.
Imagining Kant’s theory of scientific knowledge: philosophy and education in microbiology
Authors: Baquero Fernando 
Published: December 2022

AbstractIn the field of observational and experimental natural sciences (as is the case for microbiology), recent decades have been overinfluenced by overwhelming technological advances, and the space of abstraction has been frequently disdained. However, the predictable future of biological sciences should necessarily recover the synthetic dimension of “natural philosophy.” We should understand the nature of Microbiology as Science, and we should educate microbiology scientists in the process of thinking. The critical process of thinking “knowing what we can know” is entirely based on Kant’s Critique of Pure Reason. However, this book is extremely difficult to read (even for Kant himself) and almost inaccessible to modern experimental natural scientists. Professional philosophers might have been able to explain Kant to scientists; unfortunately, however, they do not get involved this type of education for science. The intention of this review is to introduce natural scientists, particularly microbiologists and evolutionary biologists, to the main rigorous processes (aesthetics, analytics, dialectics) that Kant identified to gain access to knowledge, always a partial knowledge, given that the correspondence between truth and reality is necessarily incomplete. This goal is attempted by producing a number of “images” (figures) to help the non-expert reader grasp the essential of Kant’s message and by making final observations paralleling the theory of scientific knowledge with biological evolutionary processes and the role of evolutionary epistemology in science education. Finally, the influence of Kant’s postulates in key-fields of microbiology, from taxonomy to systems biology is discussed.
Complete genome of Nakamurella sp. PAMC28650: genomic insights into its environmental adaptation and biotechnological potential
Authors: Paudel Lakshan , Ghimire Nisha , Han So-Ra , Park Hyun , Jung Sang-Hee , Oh Tae-Jin 
Published: December 2022

Abstract
The mechanisms underlying the survival of bacteria in low temperature and high radiation are not yet fully understood. Nakamurella sp. PAMC28650 was isolated from a glacier of Rwenzori Mountain, Uganda, which species belonged to Nakamurella genus based on 16S rRNA phylogeny, ANI (average nucleotide identity), and BLAST Ring Image Generator (BRIG) analysis among Frankineae suborder. We conducted the whole genome sequencing and comparative genomics of Nakamurella sp. PAMC28650, to understand the genomic features pertaining to survival in cold environment, along with high UV (ultraviolet) radiation. This study highlights the role of polysaccharide in cold adaptation, mining of the UV protection-related secondary metabolites and other related to cold adaptation mechanism through different bioinformatics tools, and providing a brief overview of the genes present in DNA repair systems. Nakamurella sp. PAMC28650 contained glycogen and cellulose metabolism pathways, mycosporine-like amino acids and isorenieratene-synthesizing gene cluster, and a number of DNA repair systems. Also, the genome analysis showed osmoregulation-related genes and cold shock proteins. We infer these genomic features are linked to bacterial survival in cold and UV radiation.
Modeling opponent learning in multiagent repeated games
Authors: Hu Yudong , Han Congying , Li Haoran , Guo Tiande 
Published: December 2022

AbstractMultiagent reinforcement learning (MARL) has been used extensively in the game environment. One of the main challenges in MARL is that the environment of the agent system is dynamic, and the other agents are also updating their strategies. Therefore, modeling the opponents’ learning process and adopting specific strategies to shape learning is an effective way to obtain better training results. Previous studies such as DRON, LOLA and SOS approximated the opponent’s learning process and gave effective applications. However, these studies modeled only transient changes in opponent strategies and lacked stability in the improvement of equilibrium efficiency. In this article, we design the MOL (modeling opponent learning) method based on the Stackelberg game. We use best response theory to approximate the opponents’ preferences for different actions and explore stable equilibrium with higher rewards. We find that MOL achieves better results in several games with classical structures (the Prisoner’s Dilemma, Stackelberg Leader game and Stag Hunt with 3 players), and in randomly generated bimatrix games. MOL performs well in competitive games played against different opponents and converges to stable points that score above the Nash equilibrium in repeated game environments. The results may provide a reference for the definition of equilibrium in multiagent reinforcement learning systems, and contribute to the design of learning objectives in MARL to avoid local disadvantageous equilibrium and improve general efficiency.
Retinal Thinning in Adults with Autism Spectrum Disorder
Authors: Friedel Evelyn B. N. , Tebartz van Elst Ludger , Schäfer Mirjam , Maier Simon , Runge Kimon , Küchlin Sebastian , Reich Michael , Lagrèze Wolf A. , Kornmeier Jürgen , Ebert Dieter , Endres Dominique , Domschke Katharina , Nickel Kathrin 
Published: December 2022

AbstractSince the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker.
Inclusion, occlusion and adsorption of rare earth elements from chloride media onto barite-gypsum composite
Authors: Abdo Sh. M. , Hagag M. S. , Ali A. H. , Salem F. H. , Dakroury G. A. 
Published: December 2022

AbstractIn this study, a synthetic BaSO4·CaSO4 composite was prepared by co-precipitation technique, characterised and examined for REE sorption. The sorption parameters were; pH = 4, equilibrium time = 20 min, temperature = 303 K, and REE liquor volume to composite mass ratio of 0.2:1 L g−1. The sorption reaction was controlled by pseudo 2nd order kinetic mechanism and Langmuir adsorption isotherm with an adsorption capacity of 168.63 mg g−1. 90.14% of REE (III) was desorbed using 1 mol L−1 HNO3. The process was endothermic and spontaneous. Accordingly, 1:1 barite-gypsum (natural ingredient for BaSO4·CaSO4), with 136 mg g−1 loading capacity, was used for REEs extraction.
Dynamics of digitally controlled forced vibration of suspended cables
Authors: Kollár László E. 
Published: December 2022

AbstractDynamics of suspended cables with active vibration control is studied. The control device is an electrical vibration absorber that is driven by a motor and that may be fixed at any position along the cable. The absorber applies a control force that reduces vibration amplitude at the position where it is placed. The methodology is efficient for attenuating high-frequency, low-amplitude vibration due to periodic excitation that may consider wind effect. The dynamic behavior is described by a mechanical model of the absorber and the cable at the location where the absorber is attached. The model takes into account such practical problems as time delay and backlash at the driving, which lead to limitation in the applicability of control. Time delay occurs in digital control, because samples of data are taken at discrete time intervals and response is provided after the sampling delay. Backlash influences control when the direction of control force changes, since the control force is not transmitted in the small domain of backlash. The present research examines the effects of time delay and backlash on the local control of cable vibration, and assesses the range of time delay and backlash when the control can be applied successfully. Moreover, the presence of time delay and backlash together results in a motion with some irregularity what justifies the detailed study of the dynamic behavior in order to evaluate the types of motion that may arise in such systems.
Efficacy and Safety of One Anastomosis Gastric Bypass Versus Roux-en-Y Gastric Bypass for Obesity: a Meta-analysis and Systematic Review
Authors: Li Xianting , Hu Xu , Fu Chendong , Han Lang , Xie Ming , Ouyang Shurui 
Published: December 2022

AbstractThe objective of this review is to systematically review the efficacy and safety outcomes of one anastomosis gastric bypass (OAGB) with Roux-en-Y gastric bypass (RYGB). From inception to July 4, 2022, a systematic literature search was performed using PubMed, Embase, and Cochrane Library for randomized clinical trials comparing OAGB with RYGB in obesity. A meta-analysis performed using the RevMan 5.4.1 software evaluations was completed. We identified 1217 reports; after exclusions, eight trials with a total of 931 patients were eligible for analysis. Compared with RYGB, OAGB had multiple advantageous indexes. Examples include percent of excess weight loss (%EWL) at 12 months (P = 0.009), body mass index (BMI) at 2 years (P < 0.00001), early postoperative complication (P = 0.04), remission of dyslipidemia (P < 0.0001), and operative time (P < 0.00001). No significant statistical difference was observed in BMI at 6 months, %EWL at 6 months, BMI at 12 months, percent of excess body mass index loss (%EBMIL) at 2 years, BMI at 5 years, intraoperative complications, late postoperative complications, remission of type 2 diabetes mellitus, and dyslipidemia or gastroesophageal reflux disease remission between OAGB and RYGB. OAGB is no less effective than RYGB; no significant differences in weight loss efficacy were observed, and more large and long-term randomized controlled trials are needed to verify this. In addition, studies have shown that OAGB has a shorter operation time, fewer early postoperative complications, and a shorter learning curve, making it easier for young surgeons to perform.
Effects of herbal cake-partitioned moxibustion on the expression of thyroid autophagy-related factors LC3B and Beclin-1 in rats with autoimmune thyroiditis
Authors: Chen Kexu , Zhao Jimeng , Qiao Yu , Zhu Lu , Huang Yan , Liu Yanan , Zheng Handan , Liu Huirong , Cui Yunhua , Wu Huangan 
Published: December 2022

Abstract
Objective
To observe the anti-inflammatory effect, as well as the effect on the expression of microtubule-associated protein light chain 3B (LC3B) and Beclin-1 of herbal cake-partitioned moxibustion in rats with experimental autoimmune thyroiditis (EAT).

Methods
Female Sprague-Dawley rats were randomly divided into a normal group and a modeling group. The EAT rat model was prepared by a combination of antigen immunization plus iodine agent induction. After the model was prepared, rats in the modeling group were randomly and equally divided into a model group and a herbal cake-partitioned moxibustion group. In the herbal cake-partitioned moxibustion group, moxibustion was alternately applied to two groups of points [Dazhui (GV14)-Mingmen (GV4) and Tiantu (CV22)-Guanyuan (CV4)], and the treatment continued for 30 d. Rats in the normal and model groups were only fixed identically without intervention. Histopathological manifestations of thyroid glands were observed by hematoxylin-eosin staining; the concentrations of thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were detected by enzyme-linked immunosorbent assay; real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry were used to detect the mRNA and protein expression of autophagy-related factors LC3B and Beclin-1 in thyroid tissue.

Results
There were massive follicular destruction, lymphocytic infiltration, and interstitial fibrous tissue hyperplasia of the thyroid glands in the model group. Some follicles of the thyroid glands were destroyed with few lymphocyte infiltrations and fibrous tissue hyperplasia in the moxibustion group. Compared with the normal group, the concentrations of serum TPOAb, TGAb, IL-1β, IL-6, and TNF-α were increased in the model rats (P<0.05); the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were reduced in the model group (P<0.05). Compared with the model group, the concentrations of serum TPOAb, TGAb, IL-1β, IL-6, and TNF-α were reduced in the herbal cake-partitioned moxibustion group (P<0.05); the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were increased in the herbal cake-partitioned moxibustion group (P<0.05). The mRNA and protein expression of LC3B and Beclin-1 in thyroid tissue was negatively correlated with the serum levels of TPOAb and TGAb.

Conclusion
Herbal cake-partitioned moxibustion reduces the inflammatory response in the thyroid glands of EAT rats and lowers the levels of serum TPOAb and TGAb. This may be related to the regulation of mRNA and protein expression of the autophagy-associated factors LC3B and Beclin-1 in rat thyroid tissue.
A nonstandard approach to asymptotic fixed point theorems
Authors: Lindstrøm Tom , Ross David A. 
Published: December 2022

AbstractWe use methods from nonstandard analysis to unify and extend results from the theory of asymptotic fixed points on metric spaces. Among the topics we consider are Kirk’s asymptotic fixed point theorem with extensions, Boyd and Wong’s fixed point theorem, and Suzuki’s fixed point theorem for asymptotic contractions of the Meier–Keeler type. We also show how Suzuki’s asymptotic contractions of the final type can be modified to yield uniform convergence on compact and bounded sets.
Validation study of a nomogram for predicting probability of low risk of MammaPrint results in women with clinically high-risk breast cancer
Authors: Hwang Young Sol , Kim Hwa Jung , Kim Jisun , Chung Il Yong , Ko Beom Seok , Kim Hee Jeong , Lee Jong Won , Son Byung Ho , Ahn Sei-Hyun , Lee Sae Byul 
Published: December 2022

Abstract
Background
MammaPrint (MMP) helps clinicians identify the ideal time for adjuvant treatment for patients with early HR+/HER2− breast cancer. We aimed to validate a nomogram designed to predict probability of low risk of MMP results and to evaluate the difference in survival outcome between two groups divided by nomogram score.

Methods
In this retrospective cohort study, we evaluated 172 patients from Asan Medical Center, Seoul, Korea, who underwent breast cancer surgery and MMP during 2020–2021. First, we validated the nomogram by calculating the area under the curve (AUC) and using calibration. Additionally, with the data of 1,835 T1-3N0-1M0 HR+/HER2− patients from Asan Medical Center during 2010–2013, we compared the disease-free survival (DFS), overall survival (OS), and breast cancer-specific survival (BCSS) rates by Kaplan−Meier analysis between the two groups divided by nomogram total point (TP) of 183.

Results
The AUC calculated by validation of 172 patients was 0.73 (95% confidence interval [CI], 0.66–0.81). The discrimination and calibration of the prediction model were satisfactory following additional validation of 1835 patients. The high-risk and low-risk groups had different 5-year OS (97.9% vs. 98.1%, p = 0.056), DFS (98.6% vs. 99.4%, p = 0.008), and BCSS rates (98.6% vs. 99.4%, p = 0.002).

Conclusion
For treatment decision-making among clinically high-risk patients with HR+/HER2− and node-positive disease, the nomogram showed satisfactory performance in predicting patients with low genomic risk. Survival outcome significantly differed between two groups divided by nomogram TP. More studies are needed to validate this model in international cohorts and large prospective cohorts from other institutions.
Initial report of percutaneous left atrial appendage closure in hemodialysis patients with atrial fibrillation and high risk of bleeding in Japan
Authors: Ueno Hiroshi , Imamura Teruhiko , Tanaka Shuhei , Ushijima Ryuichi , Fukuda Nobuyuki , Kinugawa Koichiro 
Published: December 2022

AbstractIn the countries like Japan where anticoagulation is not recommended in hemodialysis patients, the feasibility of percutaneous left atrial appendage closure (LAAC) in hemodialysis patients with non-valvular atrial fibrillation (NVAF) accompanying high risks of thromboembolic stroke and bleeding remains unknown. Peri-procedural and 45-day clinical outcomes following LAAC using WATCHMAN system, which were performed in our institute between Jun 2020 and April 2022 according to the Japanese Circulation Society guidelines, were retrospectively compared between those with and without hemodialysis. 118 patients (median 79 years, 81 men) consisting of 25 hemodialysis patients and 93 non-hemodialysis patients were included. CHADS score was 3 (2, 4) in the hemodialysis patients and 3 (2, 4) in the non-hemodialysis patients (p = 0.98). HAS-BREAD score was 4 (3, 5) in the hemodialysis patients and 3 (2, 3) in the non-hemodialysis patients (p < 0.001). All procedures were successful, except for a non-hemodialysis patient with a larger left atrial appendage. There were no major complications during index hospitalization and 45-day observational period, except for a hemodialysis patient with suspected bleeding and a non-hemodialysis patient who died due to cardiac amyloidosis. LAAC seems to be feasible in hemodialysis patients with high risks of thromboembolic events and bleedings.
Mango germplasm screening for the identification of sources of tolerance to anthracnose
Authors: Grice Kathy Rosemary Ellen , Bally Ian Stephen Edward , Wright Carole Louise , Maddox Cheryldene , Ali Asjad , Dillon Natalie Louise 
Published: December 2022

AbstractColletotrichum species are one of the most common causes of postharvest fruit rot in mango in Australia, particularly in the tropical region of north Queensland, and can result in significant losses if not managed. The research aims were to identify sources of anthracnose tolerance and to determine if host material other than fruit could improve or fast track the screening process and result in improved breeding efficiency. Access to the Australian National Mango Genebank (ANMG) collection enabled fruit screening of more than 100 Mangifera indica cultivars or Mangifera species for tolerance to anthracnose by artificial inoculation with Colletotrichum asianum over a period of 14 years. Mean lesion diameters were compared with those on a known susceptible M. indica cultivar Kensington Pride (KP) and a tolerant M. laurina cultivar Lombok. Inoculation of leaf discs and entire leaves was evaluated in the laboratory and the field as alternative assays for tolerance to anthracnose and was assessed by presence/absence of disease. Screening of fruit has shown that anthracnose tolerance within the mango germplasm is highly variable and needs to be assessed over multiple years. None of the alternative laboratory bioassays provided consistent or reliable data. The in-field artificial inoculation of immature leaf flush was successful but was not deemed suitable for adoption due to practical restraints. While resistance to anthracnose in fruit has not yet been identified, some cultivars and Mangifera spp. showed promise for inclusion as parents in future breeding programs.
First trimester lower abdominal cysts as early predictor of anorectal malformations
Authors: Erculiani Marta , Trovalusci Emanuele , Zanatta Cinzia , De Lorenzis Maria Sonia , Filippi Elisa , Bracalente Gabriella , Midrio Paola 
Published: December 2022

Abstract
Introduction
Prenatal ultrasound diagnosis of anorectal malformations (ARMs) is challenging and often missed as direct visualization of the anal sphincter is not routinely performed, plus the technique is operator-dependent and inaccurate, also in expert hands. Other indirect signs, such as rectosigmoid overdistension or intraluminal calcifications, are occasionally present in late pregnancy. The detection of a cyst of the lower abdomen in the first trimester may be an early sign of ARM. Here we reported our experience and a review of the literature of such cases.

Material and methods
Isolated cases of lower abdomen cysts encountered in the first trimester at the Prenatal Diagnosis Unit during the last 5 years were retrieved and compared with those found in literature. Post-natal clinical data were analyzed to check the presence and type of malformations.

Results
A total of three cases of lower abdomen cysts were found in our center and 13 in literature. In our case series all the cysts spontaneously regressed and were no longer visible since the second trimester of pregnancy, while in literature this was reported in only 4 out of 13 cases. ARM was confirmed in all patients at birth or post-mortem.

Conclusions
The finding of a lower abdomen cyst during the first trimester of pregnancy could be an early predictive sign of ARM, even if it disappears during pregnancy. In these cases, we suggest mentioning to the parents the possibility of an ARM during the counseling and to refer the couple to a Colorectal Center.

Graphical Abstract
A Basic Time Series Forecasting Course with Python
Authors: Zemkoho Alain 
Published: December 2022

AbstractThe aim of this paper is to present a set of Python-based tools to develop forecasts using time series data sets. The material is based on a 4-week course that the author has taught for 7 years to students on operations research, management science, analytics, and statistics 1-year MSc programmes. However, it can easily be adapted to various other audiences, including executive management or some undergraduate programmes. No particular knowledge of Python is required to use this material. Nevertheless, we assume a good level of familiarity with standard statistical forecasting methods such as exponential smoothing, autoregressive integrated moving average (ARIMA), and regression-based techniques, which is required to deliver such a course. Access to relevant data, codes, and lecture notes, which serve as based for this material, is made available (see https://github.com/abzemkoho/forecasting) for anyone interested in teaching such a course or developing some familiarity with the mathematical background of relevant methods and tools.