bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-Term Warm-Water Immersion for Improving Whole-Body Heat Loss in Older Men
Authors: Janetos Kristina-Marie T. , O’Connor Fergus K. , Meade Robert D. , Richards Brodie J. , Koetje Nick J. , Kirby Nathalie V. , McCormick James J. , Flouris Andreas D. , Kenny Glen P. 
Published: January 2025

ABSTRACT

Purpose
Exercise-induced heat acclimation can mitigate age-related reductions in heat-loss capacity, though performing repeated bouts of strenuous exercise in the heat may be untenable for many older adults. While short-term passive heat acclimation (e.g., ≤7 days of warm-water immersion) enhances whole-body heat loss in young adults, evidence of its efficacy in older adults is lacking. Thus, we examined whether 7-days warm-water immersion would improve whole-body heat loss in older adults.

Methods
Twelve habitually active older men (median [IQR] age: 68 [64-73] years; peak oxygen uptake (V̇O2peak): 34.1 [29.4-36.1] mLO2·kg-1·min-1) completed 7 consecutive days of ~90-minutes warm-water immersion (~40 °C) with core (rectal) temperature clamped at ~38.5 °C for the final 60 minutes. Before and after the warm-water immersion intervention, whole-body total (evaporative + dry) heat loss was measured via direct calorimetry during three, 30-minute bouts of cycling at increasing fixed rates of metabolic heat production (150, 200, 250 W·m-2), each separated by 15-minutes rest, in a hot-dry environment (40 °C, ~13% relative humidity). Rectal temperature and heart rate were measured continuously.

Results
Following 7 days of warm-water immersion, whole-body total heat loss was elevated by 23 [95% confidence interval: 14, 31] W·m-2 across exercise bouts (acclimation-effect: P < 0.001; interaction: P = 0.598). This was paralleled by reductions in core temperature and heart rate of 0.3 [0.2, 0.4] °C and 11 [8, 14] beats·min-1 (both, acclimation-effect: P < 0.001; interaction: P = 0.288), respectively.

Conclusions
Seven consecutive days of warm-water immersion improved whole-body heat loss and reduced core temperature and cardiovascular strain across light-to-vigorous intensity exercise in habitually active older men. Passive heat acclimation may be an efficacious alternative to exercise-heat acclimation to improve heat-loss capacity. Studies are warranted to assess effectiveness in more heat-vulnerable populations.
Η παιδαγωγική αξιοποίηση του ντοκιμαντέρ «Στα χνάρια του Θεόδωρου Κολοκοτρώνη» στο μάθημα της Ιστορίας
Authors: Σοφός Αλιβίζος (Λοΐζος) , Ρέτση Σπυριδούλα , Πολυχρονοπούλου Μαρίνα , Τσούρα Μαρία 
Published: January 2025

Ο στόχος του παρόντος άρθρου είναι να διερευνηθεί η αξιοποίηση του ιστορικού ντοκιμαντέρ στη διδασκαλία της ιστορίας. Τα ντοκιμαντέρ με θέμα την ζωή και τη δράση ιστορικών προσώπων, αποτελούν ένα πρωτοποριακό εκπαιδευτικό εργαλείο που συμβάλλουν ουσιαστικά στη διδασκαλία της ιστορίας, βελτιώνοντας σημαντικά όχι μόνο τις ιστορικές γνώσεις των μαθητών/τριών αλλά και τη στάση τους απέναντι στο μάθημα της ιστορίας. Με τη χρήση σύγχρονων τεχνολογιών και μιας μαθητοκεντρικής προσέγγισης, το ντοκιμαντέρ προσφέρει στους/στις μαθητές/τριες μια μοναδική ευκαιρία να εμβαθύνουν στην οπτικοποίηση και κατανόηση δυσνόητων και μακρινών ιστορικών γεγονότων. Το ντοκιμαντέρ «Στα χνάρια του Θεόδωρου Κολοκοτρώνη», τοποθετεί τον θεατή στα ίχνη του μεγάλου στρατηγού, επιχειρεί να τον μυήσει σε μια συναρπαστική περιήγηση στη ζωή και το έργο του. Το βίντεο προσφέρει στους/στις μαθητές/τριες μια ζωντανή εικόνα των σημαντικότερων σταδίων της ζωής του Κολοκοτρώνη, από την παιδική του ηλικία μέχρι τον θάνατό του, μέσα από την οπτικοακουστική αφήγηση, η οποία είναι προσαρμοσμένη στις ανάγκες τους. Ακόμα, το ντοκιμαντέρ δίνει έμφαση στον τόπο και τον χρόνο, επιτρέποντας στους/στις μαθητές/τριες να κατανοήσουν καλύτερα το ιστορικό πλαίσιο μέσα στο οποίο εξελίχθηκαν τα γεγονότα, να προσελκύσει το ενδιαφέρον τους για την ιστορία, να τους/τις παρακινήσει να διερευνήσουν περαιτέρω το θέμα και να αλλάξουν στάση απέναντι στο μάθημα.
Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1)
Authors: Madaras Laszlo , Anvari Radean , Schuchardt-Peet Claudia , Hoskote Abhinav , Kashyap Rahul 
Published: January 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. A co-infection with both viruses is rare, particularly in the United States. Case description: An 85-year-old male presented to the Emergency Department with recurrent falls, diarrhoea and cough, and whose viral panel was positive for both SARS-COV-2 and HCoV-HKU1. The patient developed bacterial pneumonia and was treated with antibacterial agents and glucocorticoids. His past medical history of atrial fibrillation required careful monitoring and subsequent discontinuation of remdesivir, a medication known to cause adverse cardiovascular effects in COVID-19 patients. The length of stay was also prolonged due to delirium and deconditioning. Ultimately, the patient required an urgent ablation followed by the placement of a permanent pacemaker, and anticoagulation therapy was initiated before discharge. The patient had a favourable outcome given the rarity of this case. Discussion: COVID-19 patients co-infected with other human coronaviruses should be monitored for disease progression and superimposed bacterial infections. Providers should be cautious with the use of remdesivir in cases of co-infection and in severely ill COVID-19 patients who have a history of atrial fibrillation.
Perceptions and practices of imaging personnel and physicians regarding the use of brain MRI for dementia diagnosis in Uganda
Authors: Nassanga Rita , Nakasujja Noeline , Kaddumukasa Mark , Jones Stephen E. , Sajatovic Martha , Kawooya Michael Grace 
Published: January 2025

Introduction
Diagnosing dementia remains challenging in low-income settings due to limited diagnostic options and the absence of definitive biomarkers. The use of brain MRI in the diagnosis of dementia is infrequent in Uganda, and even when it is used, subtle findings like mild regional atrophy are often overlooked, despite being crucial for imaging diagnosis.

Objective
The purpose of this study was to explore the perceptions and practices of imaging personnel and physicians regarding the use of brain MRI as a diagnostic approach for dementia in Uganda.

Methods
This was an exploratory qualitative study involving radiologists, technologists, senior house officers and psychiatrists. The participants were 25 in total. Data was collected through key informant interviews and focus group discussions and analyzed thematically using an inductive approach.

Results
The study revealed three key themes: Brain MRI Practices for Diagnosing Dementia, Facilitators of Appropriate MRI Use, and Barriers to Appropriate Use of Brain MRI. Sub-themes under these themes included cost considerations, poor and good MRI practices, MRI as a standard operating procedure, positive attitudes towards brain MRI, and barriers such as structural, financial, operational, technical, and patient-related issues. Participants acknowledged the high accuracy and superiority of brain MRI for diagnosing dementia and recognized it as the standard of care. However, its use in Uganda is limited due to high costs, restricted access, mechanical failures, patient claustrophobia, myths and misconceptions, and interpretation difficulties by radiologists and inappropriate protocols by technologists.

Conclusion
The study identifies barriers to effective brain MRI use for dementia diagnosis in Uganda, including limited training, high costs, and uneven equipment distribution. Despite this, providers are positive about MRI adoption. Enhancing training, awareness, and phased rollouts can improve outcomes. Future research should focus on similar low-resource settings for validation.
Kidney and gallbladder stones and the risk of prostate cancer: Results from the EPICAP study
Authors: Sawaya Melissa , Cordina-Duverger Emilie , Lamy Pierre-Jean , Trétarre Brigitte , Menegaux Florence 
Published: January 2025

Background
Prostate cancer remains the most frequent cancer among men, representing a significant health burden. Despite its high morbidity and mortality rates, the etiology of prostate cancer remains relatively unknown, with only non-modifiable established risk factors. Chronic inflammation has emerged as a potential factor in prostate carcinogenesis. We investigated the role of kidney and gallbladder stones and the risk of prostate cancer.

Methods
We used data from EPICAP, a population-based case-control study. A total of 819 diagnosed prostate cancer cases and 879 controls were face-to-face interviewed using a standardized questionnaire that collected information on personal medical history, including history of kidney and gallbladder stones. Odds Ratios (OR) and their 95% confidence interval (CI) were estimated using multivariate unconditional logistic regression.

Results
Our study revealed intriguing patterns regarding kidney and gallbladder stones in relation to prostate cancer risk. The analysis indicated significant potential associations between kidney stones and the risk of prostate cancer (OR: 1.46 95% CI: 1.13–1.90), particularly in men with a history of kidney infection. Additionally, our data suggested a possible relationship between gallbladder stones and prostate cancer when considering triglyceride (OR: 2.27, 95% CI: 0.99–5.28), although further research is needed for a conclusive understanding.

Conclusions
Our results suggest an association between calculi and the risk of prostate cancer. Findings from this study underscore the need for a more comprehensive investigation to understand the role of chronic inflammation or metabolism and delineate the mechanisms underlying these potential associations in order to guide the development of targeted preventive strategies for aggressive prostate cancer.
Progranulin measurement with a new automated method: a step forward in the diagnostic approach to neurodegenerative disorders
Authors: Cosma Chiara , Talli Ilaria , Pangrazzi Elisa , Padoan Andrea , Cerutti Helena , Zaninotto Martina , Gabelli Carlo , Plebani Mario 
Published: January 2025

Abstract

Objectives
Mutations in the GRN gene encoded glycoprotein progranulin (PGRN), cause 5–10 % of all cases of frontotemporal lobar degeneration (FTLD). The aim of our study was to verify the analytical and clinical performance of an automated chemiluminescent immunoassay method for PGRN measurement recently developed (Chorus Evo, Diesse Diagnostica, Italy).

Methods
Five plasma pools and residual plasma samples (K2EDTA) from 25 control subjects (11 males, 62–79 years; 14 females, 54–76 years) and 151 patients (70 males, 53–81 years; 81 females, 44–82 years) with different neurodegenerative disorders (NDs), were assayed. In 61 out of 151 patients, genetic GRN screening was carried.

Results
Within-run imprecision (CV%) ranged from 3.8 % (11.5 pg/L) to 10.8 % (2.5 pg/L), and between-run, from 5.6 % (68.7 pg/L) to 10.7 % (2.8 pg/L). At genetic screening, 3 out of 61 patients were classified as GRN+ carriers, 18 as “other mutations” and 40 as “no-mutations” carriers. The PGRN median level in GRN+ carriers (15.9 pg/L) was significantly lower than that in control subjects (32.8 pg/L; p=0.006), in GRN− (27.50 pg/L; p=0.007), in other mutation carriers (24.80 pg/L; p=0.05) and in NDs patients (22.40 pg/L; p=0.05) ROC analysis, demonstrates the accuracy of progranulin levels in discriminating between “GRN+” and “GRN−” carriers (AUC 0.985) as well as “GRN+” and “other mutations” carriers (AUC 0.870).

Conclusions
The new automated progranulin method, for robust analytical performance, is suitable for use in the clinical setting, supporting clinicians in making a differential diagnosis in patients with neurodegenerative disorder.
A geometric approach to characters of Hecke algebras
Authors: Abreu Alex , Nigro Antonio 
Published: January 2025

Abstract
To any element of a connected, simply connected, semisimple complex algebraic group 𝐺 and a choice of an element of the corresponding Weyl group, there is an associated Lusztig variety.
When the element of 𝐺 is regular semisimple, the corresponding variety carries an action of the Weyl group on its (equivariant) intersection cohomology.
From this action, we recover the induced characters of an element of the Kazhdan–Lusztig basis of the corresponding Hecke algebra.
In type 𝐴, we prove a more precise statement: that the Frobenius character of this action is precisely the symmetric function given by the characters of a Kazhdan–Lusztig basis element.
The main idea is to find cellular decompositions of desingularizations of these varieties and apply the Brosnan–Chow palindromicity criterion for determining when the local invariant cycle map is an isomorphism.
This recovers some results of Lusztig about character sheaves and gives a generalization of the Brosnan–Chow [P. Brosnan and T. Y. Chow, Unit interval orders and the dot action on the cohomology of regular semisimple Hessenberg varieties, Adv. Math.
329 (2018), 955–1001] solution to the Shareshian–Wachs [J. Shareshian and M. L. Wachs, Chromatic quasisymmetric functions, Adv. Math.
295 (2016), 497–551] conjecture to non-codominant permutations, where singularities are involved.
Dynamics of particulate emissions in the presence of autonomous vehicles
Authors: Briani Maya , Denaro Christopher Anthony , Piccoli Benedetto , Rarità Luigi 
Published: January 2025

Abstract
Around one third of

CO

2

{{\rm{CO}}}_{2}

emissions in the atmosphere are linked to vehicular traffic. Pollutant agents have an impact on the environment, in particular, the increased presence of particulate matter (PM) creates negative effects on human health. This article examines how autonomy could positively reduce the emission of air pollutants due to traffic. The methodology involves the analyses of PM emissions as a function of traffic conditions, especially in the presence of autonomous vehicles (AVs) dampening traffic waves. The starting point is traffic measurements that, gathered from real experiments involving a fleet of vehicles moving on a ring track, exhibit the presence of stop-and-go waves that are dampened by control strategies implemented on a unique AV. Using a system of ordinary differential equations modeling the principal chemical reactions in the atmosphere, it is proved that wave dampening implies a significant decrease in PM emissions at ground level. The horizontal diffusion of the pollutants is estimated by partial differential equations combined with the model for chemical reactions. The obtained outcomes show advantages given by the improvements in traffic flows and the mitigation effect of green barriers.
Pediatric Advance Care Planning and Adolescent Preparedness and Quality of Life: An RCT
Authors: Friebert Sarah , Trujillo Rivera Eduardo A. , Baker Justin N. , Thompkins Jessica D. , Grossoehme Daniel , Needle Jennifer , Lyon Maureen E. 
Published: January 2025

BACKGROUND AND OBJECTIVE
To evaluate the efficacy of Family-Centered Advance Care Planning for Teens With Cancer (FACE-TC) on adolescents’ quality of life.

METHODS
A clinical trial randomized adolescent-family dyads at a 2:1 ratio to either FACE-TC or control. FACE-TC dyads received 3 weekly 60-minute sessions: Lyon Pediatric Advance Care Planning Survey; Next Steps: Respecting Choices; and Five Wishes. Generalized mixed-effect models evaluated efficacy at 3, 6, and 12 months after intervention measured by FACIT-SP-Ex-V4 (meaning/peace, faith) and PROMIS pediatric (anxiety; depressive symptoms; pain interference, fatigue). Fisher exact tests assessed decisional support and preparedness.

RESULTS
Adolescents (n = 126) were mean age 17 years, 57% female, and 79% white. No significant differences were found between groups for faith or meaning/peace. At 12 months after intervention compared to control, FACE-TC increased anxiety (mean ratio 1.14; CI 1.04–1.25), depressive symptoms (mean ratio 1.12; CI 1.02–1.22), and pain interference (mean ratio 1.10; CI 1.00–1.20), but not at 3 or 6 months. FACE-TC increased fatigue at 3 months (mean ratio 1.13; CI 1.02–1.26), but not at 6 or 12 months. Compared to control, adolescents participating in FACE-TC agreed that “I feel prepared for the future” (76% vs 94%) and “I feel we are now on the same page” (76% vs 94%) at 3 months, but not at 12 months.

CONCLUSIONS
There were no significant differences in quality of life between groups until 1 year, except for fatigue. FACE-TC had late effects, increasing adolescents’ anxiety, depressive symptoms, and pain interference. Reassessment at 1 year is clinically important.
Autoridad pedagógica y estereotipos de género en la práctica docente universitaria
Authors: Cubillas Rodríguez María José , Hernández Camarena Karla Beatriz , Abril Valdez Elba 
Published: January 2025

La autoridad pedagógica juega un papel clave en la formación del estudiantado y es permeada por las ideas, creencias y representaciones de género en la educación superior. A través de esta autoridad se puede generar una influencia social y cultural en la población estudiantil con implicaciones en expectativas y trato diferenciado según el género, que afectan los procesos de enseñanza-aprendizaje y contribuyen a reproducir desigualdades. Este artículo analiza cómo desde la perspectiva estudiantil el vínculo de autoridad pedagógica es permeado por creencias y representaciones de género en la educación superior en universidades del norte de México. El estudio se sitúa dentro de un enfoque metodológico mixto con alcance descriptivo y técnicas de encuesta y entrevista semiestructurada dirigidas a estudiantes universitarios de tres universidades. El análisis cuantitativo dio lugar a un modelo de cuatro factores: prácticas discriminatorias y sexistas en los procesos educativos, creencias sobre competencias y capacidades por sexo, incorporación del enfoque de género en la asignatura y trato igualitario y lenguaje inclusivo. Mientras que lo expresado en las entrevistas resalta aspectos sobre lenguaje sexista en los espacios educativos, estereotipos de género que limitan oportunidades, trato diferenciado por sexo y transiciones hacia la igualdad y equidad. De manera que la normalización de estereotipos de género en el ámbito educativo afecta no solo las decisiones de carrera de las personas estudiantes, sino que también crea barreras psicológicas que pueden limitar su éxito y participación. Estos hallazgos muestran una dualidad en el ejercicio de la autoridad pedagógica. Las relaciones educativas implican una capacidad transformadora, por ello la formación y sensibilización sobre género y diversidad pueden ser herramientas valiosas para ayudar a los docentes a reconocer y superar estos sesgos.
Autoprotección, solastalgia y cuidado en los conflictos por el agua: estudio multicaso en el oriente antioqueño, Colombia
Authors: Arias Beatriz , Jiménez Ospina Laura , Vasco Vargas Vanessa , Parra Mojica Elsa Pilar 
Published: January 2025

Objetive. To understand the self-protection strategies developed by communities and organizations in the face of violations derived from construction and licensing projects for hydropower generation. Methodology. Qualitative study carried out in hydro-social territories of the rivers La Paloma, Santo Domingo and Dormilón, municipalities of Argelia, San Francisco and San Luis, Eastern Antioquia, Colombia. The study included document review, territorial walks, semi-structured interviews and social mapping exercises over the course of one year from April 2022. Results. Self-protection strategies are mediated by affective-emotional links with the territory, whose transformations generate feelings related to the notion of solastalgia. Self-protection is a strategy to collectively sustain living spaces and workers around the river, with a view to future generations. Conclusion. Self-protection in these communities is updated and amplified to protect not only people’s physical integrity, but also and above all the integrity of the territory as a space of bonds, affections and emotions.
Intracortical inhibiton assessment using threshold tracking technique in amyotrophic lateral sclerosis
Authors: Bakulin I. S. , Zabirova A. Kh. , Poydasheva A. G. , Sinitsyn D. O. , Lagoda D. Yu. , Nagieva A. R. , Zakharova M. N. , Suponeva N. A. , Piradov M. A. 
Published: January 2025

Background. Assessment of short-interval intracortical inhibition (SICI) using paired-pulse transcranial magnetic stimulation (TMS) and the threshold tracking technique is a promising approach to develop biomarkers of motor cortex damage in amyotrophic lateral sclerosis (ALS). Both high sensitivity and specificity of this approach were shown previously; however, almost all studies in this field were conducted by one group of authors.Aim. The replication of data showing impairment of SICI assessed by threshold tracking technique in patients with ALS.Materials and methods. 18 patients with ALS and 13 healthy volunteers were included into the study. Functional state of the patients was assessed as well as disease duration, form, stage and progression rate. Following values were determined in all participants using TMS: 1) resting motor threshold (MT); 2) mean motor evoked potential (MEP) amplitude of 30 stimuli applied with an intensity of 120 % MT; 3) SICI assessed using an algorithm based on paralleled optimized threshold tracking with interstimulus interval (ISI) of 1.0 ms, 1.5 ms, 2.0 ms, 2.5 ms, 3.0 ms, 3.5 ms, 4.0 ms, 5.0 ms, 7.0 ms, as well as mean inhibition for values with ISI from 1.0 to 3.0 ms and from 1.0 to 7.0 ms.Results. No significant differences between groups were observed for MT and MEP amplitude. Significant decrease of SICI with ISI 1.0 and 2.0 ms as well as mean SICI from 1.0 and 3.0 ms was observed in ALS. No significant correlations of MT, MEP amplitude or SICI with clinical values were found.Conclusion. This replication study has shown the ability of paired-pulse TMS with threshold tracking technique to identify the impairment of intracortical inhibition in patients with ALS.
Technology Validation of Leguminous Plants Enzyme-based Formulated Feeds for Hog Industries
Authors: Bollido Marcos E. , Gomba Felisa E. 
Published: January 2025

Background: This study aims to validate Leguminous Plants Enzyme Based Formulated Feeds (LPEBFF) nutrient content; comparative analysis of LPEBFF versus Commercial Feeds (CF); growth performance of hogs; cost of feeds; meat quality and to determine the significant difference among hogs in terms of growth performance, quality of meat and cost using the LPEBFF and commercial feeds. Methods: The study utilized an experimental and descriptive research design using a quantitative research method. T0 with 100% CF, T1 50% CF and 50% LPEBFF and T2 100% LPEBFF. Nine heads of hog were allocated in the study. Result: T2 displayed a significant crude protein content while a gradual decrease in its crude fiber content occurred subsequently. In T0 hogs achieved the highest mean weight of 60.32 kg, followed by T1 36.44 kg and T2 19.31 kg. T0 with 100% CF, shows the highest total expenses, amounting to 11,452.66, as compared to T1 8,956.33 and T2 6,463.33. Positive profit for T2 740.84, with potential financial benefit. In contrast, both T0 and T1 show negative profits, indicating financial losses. General acceptability of meat quality consistently rises from T0 to T2, culminating in the mean score of 5.96 in T2 signifying a favorable result in the overall evaluation. Meat quality on appearance and thickness between CF and LPEBFF less than 0.001 was obtained and the correlation is significant less than 0.05 favorable in T2.