bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographic and hydromorphologic controls on interactions between hyporheic flow and discharging deep groundwater
Authors: Morén Ida , Mojarrad Brian , Riml Joakim , Wörman Anders 
Published: February 2023

AbstractHyporheic exchange flow (HEF) at the streambed–water interface (SWI) has been shown to impact the pattern and rate of discharging groundwater flow (GWF) and the consequential transport of heat, solutes and contaminants from the subsurface into streams. However, the control of geographic and hydromorphological catchment characteristics on GWF–HEF interactions is still not fully understood. Here, the spatial variability in flow characteristics in discharge zones was investigated and averaged over three spatial scales in five geographically different catchments in Sweden. Specifically, the deep GWF discharge velocity at the SWI was estimated using steady-state numerical models, accounting for the real multiscale topography and heterogeneous geology, while an analytical model, based on power spectral analysis of the streambed topography and statistical assessments of the stream hydraulics, was used to estimate the HEF. The modeling resulted in large variability in deep GWF and HEF velocities, both within and between catchments, and a regression analysis was performed to explain this observed variability by using a set of independent variables representing catchment topography and geology as well as local stream hydromorphology. Moreover, the HEF velocity was approximately two orders of magnitude larger than the deep GWF velocity in most of the investigated stream reaches, indicating significant potential to accelerate the deep GWF velocity and reduce the discharge areas. The greatest impact occurred in catchments with low average slope and in reaches close to the catchment outlet, where the deep GWF discharge velocity was generally low.
Enhanced Expression of Plasminogen Activators and Inhibitor in the Healing of Tympanic Membrane Perforation in Rats
Authors: Makuszewska Maria , Cieślińska Magdalena , Winnicka Maria M. , Skotnicka Bożena , Niemczyk Kazimierz , Bonda Tomasz 
Published: February 2023

AbstractThe significance of plasminogen activation during the tympanic membrane (TM) healing is known mainly from studies performed on knock-out mice. In the previous study, we reported activation of genes coding proteins of plasminogen activation and inhibition system in rat’s TM perforation healing. The aim of the present study was the evaluation of protein products expressed by these genes and their tissue distribution using Western blotting and immunofluorescent method, respectively, during 10-day observation period after injury. Otomicroscopical and histological evaluation were employed to assess the healing process. The expression of urokinase plasminogen activator (uPA) and its receptor (uPAR) were significantly upregulated in the proliferation phase, with subsequent gradual attenuation during remodeling phase of healing process, when keratinocyte migration was weakening. The expression of plasminogen activator inhibitor type 1 (PAI-1) also showed the highest levels during the proliferation phase. The increase of tissue plasminogen activator (tPA) expression was observed during the whole observation period, with the highest activity during the remodeling phase. Immunofluorescence of these proteins was present mainly in migrating epithelium. Our study found that plasminogen activation (uPA, uPAR, tPA) and inhibitory (PAI-1) molecules form a well-structured regulatory system of the epithelial migration that is critical to the healing of TM after its perforation.
Wolf attacks on hunting dogs are negatively related to prey abundance in Finland: an analysis at the wolf territory level
Authors: Kojola Ilpo , Hallikainen Ville , Nivala Vesa , Heikkinen Samuli , Tikkunen Mari , Huhta Esa , Ruha Leena , Pusenius Jyrki 
Published: February 2023

Abstract
Attacks by wolves (Canis lupus) on dogs (C. familiaris) presumably are motivated both by preying and elimination of potential competitors. Regardless of these alternative motivations in wolves, the risk of attacks might be higher when the density of primary prey is low. We examined how many dogs do territorial wolves in Finland kill in relation to the population density of the most abundant ungulates, moose (Alces alces), white-tailed deer (Odocoileus virginianus), and roe deer (Capreolus capreolus). Most attacks by wolves on dogs take place in hunting with dogs. The number of wolf-killed dogs was in highly significant negative relationship to the population density of white-tailed deer and to total ungulate biomass per unit area which is largely determined by the density of white-tailed deer. Our results indicate that abundant wild prey would decrease the risk at which wolves attack dogs. On the other side of the coin prevail two hard facts which wildlife managers had to take a notice. White-tailed deer, although a potential mitigator of wolf–human conflict, is an alien species and a partner in > 6000 traffic collisions annually in Finland. One factor that seemed to increase the risk of wolf attacks on dogs is the low ungulate density in regions where moose is the only remarkable ungulate prey. Higher moose densities could decrease the risk of attacks, but on the other hand, higher densities could increase the risk of serious traffic collisions and browsing damages in forests.
Cluster strategy as a public policy option for aquaculture development in Mexico: the case for tilapia
Authors: Hernández-Arzaba Juan Cristóbal , Failler Pierre , Asiain-Hoyos Alberto , Platas-Rosado Diego Esteban , Forse Andy , Drakeford Benjamin M. , Muñoz-Madrid Alba Rocío , Limón-Rivera Rogelio 
Published: February 2023

Abstract
The objective of this paper was to demonstrate that the promotion of aquaculture clusters as a policy option for developing tilapia aquaculture in Mexico, resulting from glocal externalities as competitive advantages to the global market, is necessary to further develop the sector. The farmed tilapia clusters were described using data from the Veracruz Aquaculture Census, 2010. We then utilise three theories. Firstly, we focus on North (1955) and Krugman (1995) and find that Economic geography and localisation verified that conglomeration is a function of natural resources and population zones. Secondly, we investigate the Porter value system. Cluster competitive advantage was identified in water availability and water access, electric supply coverage, product presentation, and the local market. Thirdly, we apply the Altenburg and Meyer-Stamer (1999) model to identify cluster type, which classifies typology based on natural resource access and the inputs and technologies commercial balance. The Veracruz Tilapia cluster diagnostic showed an incipient development with remarked opportunity areas, where efforts should be directed, supported by a cluster strategy. However, Mexico and the Port city of Veracruz should diversify their economy. We conclude that adopting a cluster strategy for aquaculture is necessary in Mexico to both increase global competitiveness and to supply the local market.
Preliminary nonlinear analysis of a scaled masonry building under shaking test for the blind prediction of the SERA AIMS project
Authors: Ramaglia Giancarlo , Lignola Gian Piero , Prota Andrea 
Published: February 2023

AbstractExperimental tests performed on scaled masonry buildings provide key information to improve the knowledge under seismic actions. Masonry buildings behavior is strongly influenced by their physical and mechanical parameters under dynamic actions. In fact, the actual structural behavior is very complex to predict due to the significant variability of the input parameters and the strong heterogeneity of masonry. Furthermore, the behavior of masonry buildings is often influenced by the interaction with adjacent building units. In this context, the SERA AIMS project aims to improve knowledge on the interaction between adjacent buildings. In order to assess the seismic capacity of masonry structures and their damage evolution, nonlinear models often require a numerical calibration of nonlinear parameters. Simplified Finite Element (FE) models, with some very simple assumptions, can be more suitable for complex problems like as the interaction between adjacent building aggregates. The low initial knowledge level in the SERA AIMS blind competition favored simple assumptions. The availability of simple models allowed to perform consecutive time histories including the cumulative effects of previous signals. In fact, the tested prototype was subjected to many replicas. The masonry structure and the crucial interfaces between the units have been modelled by means of nonlinear elements according to the reduced knowledge level at the blind prediction stage. The main goal was to estimate the key information of a masonry building under seismic action like as: triggering and the type of damage at the most stressed areas and therefore the load threshold at which evident damage is expected. Global FE model provides information on the global behaviour (in plane behaviour), while, according to the failure models typically found in masonry buildings, kinematic analyses have been performed to assess the out of plane (local) behaviour, too. The numerical results obtained by the preliminary analysis have been compared with the experimentally detected damages. The simplified approach, based on limited information without calibration, discussed in this paper, represents a useful support tool to design dynamic tests on full-scale or scaled masonry buildings, but also to assess the vulnerability of real masonry structures.
In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma
Authors: Varatanovic Sara , Maier Tobias , Al-Gboore Sega , Stoiber Stefan , Kandathil Sam Augustine , Quint Clemens , Brennus Charlotte , Heiduschka Gregor , Kadletz-Wanke Lorenz , Brkic Faris F. 
Published: February 2023

Summary

Background
New chemotherapy agents are warranted for head and neck squamous cell carcinoma (HNSCC), particularly for incidence-rising HPV-positive tumors. Based on the evidence of Notch pathway involvement in cancer promotion and progression, we aimed to gain insights into the in vitro antineoplastic effects of gamma-secretase inhibition in HPV-positive and -negative HNSCC models.

Methods
All in vitro experiments were conducted in two HPV-negative (Cal27 and FaDu) and one HPV-associated HNSCC cell line (SCC154). The influence of the gamma-secretase inhibitor PF03084014 (PF) on proliferation, migration, colony forming, and apoptosis was assessed.

Results
We observed significant anti-proliferative, anti-migratory, anti-clonogenic, and pro-apoptotic effects in all three HNSCC cell lines. Furthermore, synergistic effects with concomitant radiation were observable in the proliferation assay. Interestingly, effects were slightly more potent in the HPV-positive cells.

Conclusion
We provided novel insights into the potential therapeutic relevance of gamma-secretase inhibition in HNSCC cell lines in vitro. Therefore, PF may become a viable treatment option for patients with HNSCC, particularly for patients with HPV-induced malignancy. Indeed, further in vitro and in vivo experiments should be conducted to validate our results and decipher the mechanism behind the observed anti-neoplastic effects.
Policies to Promote Carbon Capture and Storage Technologies
Authors: Golombek Rolf , Greaker Mads , Kverndokk Snorre , Ma Lin 
Published: February 2023

AsbstractWe model the value chain of Carbon Capture and Storage (CCS) by focusing on the decisions taken by actors involved in either capture, transport or storage of CO2. Plants emitting CO2 are located apart. If these invest in carbon capture facilities, the captured CO2 is transported to terminals, which again transport the received amount of CO2 to a storage site. Because of network effects, we may have three equilibria: one with no CCS, one with low investments in CCS, and one with high investments in CCS. In a numerical specification of the model, we find that the market for CCS may be in a state of excess inertia, i.e., even if the social cost of carbon is sufficiently high to justify investment from a social point of view, the market actors may not succeed in coordinating their efforts to reach the equilibrium with high investment. The government should then consider offering economic incentives to investments. In addition to the network effect, several other market imperfections exist, such as market power, economics of scale and the environmental externality from CO2 emissions. We identify policy instruments—in addition to a correctly set carbon tax—that will correct for the remaining market imperfections and bring private investments in line with the first-best levels. Without correction, too many terminals are set up and too few plants invest in capture facilities in our reference market structure.
Mathematical Pluralism and Indispensability
Authors: Jonas Silvia 
Published: February 2023

AbstractPluralist mathematical realism, the view that there exists more than one mathematical universe, has become an influential position in the philosophy of mathematics. I argue that, if mathematical pluralism is true (and we have good reason to believe that it is), then mathematical realism cannot (easily) be justified by arguments from the indispensability of mathematics to science. This is because any justificatory chain of inferences from mathematical applications in science to the total body of mathematical theorems can cover at most one mathematical universe. Indispensability arguments may thus lose their central role in the debate about mathematical ontology.
Field Experimental Investigations on the Performance of an Environmentally Friendly Soap-Based Firefighting Agent on Indonesian Peat Fire
Authors: Kanyama Takahide , Fukuda Naomi , Uezu Kazuya , Kawahara Takayoshi 
Published: February 2023

AbstractPeat fires contribute to global warming and environmental destruction. Once ignited, the fires tend to spread deep, underground and are difficult to extinguish using solely water. Mixtures of soap-based firefighting agents and water are expected to improve suppression efficiency by enhancing the permeability of water, a cooling material. Nevertheless, peat fire suppression is rarely studied. We performed peat fire extinguishing experiments in Palangkaraya, Indonesia to evaluate the efficiency of an environmentally friendly soap-based agent; and we conducted field experiments on 1.5 m × 1.5 m as well as 7 m × 7 m of peatlands. We conducted firefighting activities by applying (1) groundwater as well as (2) a solution of groundwater and 1 vol% of a soap-based firefighting agent. Surface temperatures of peat fires were approximately 160°C and 66°C after initial firefighting activities using solely water and a 1 vol% soap-based solution, respectively. The quantity of water required to extinguish the fires was 7.2 L/m2 using solely water, and decreased to 3.6 L/m2 using the soap-based solution. The soap-based solution exhibited a higher heat removal effect on the peat soil surface and higher permeability into peat soil than solely water, and can therefore be used to quickly extinguish peat fires. 10 months after the experiment, experimental sites sprayed with the soap-based solution demonstrated recovery of vegetation to the same degree as the sites sprayed solely with water. Thus, the soap-based firefighting agent is environmentally friendly, has promising firefighting properties, and is a reasonable tool for mitigating peat fires.
Earthquake Characteristics and Structural Properties of the Southern Tyrrhenian Basin from Full Seismic Wave Simulations
Authors: Nardoni Chiara , De Siena Luca , Magrini Fabrizio , Cammarano Fabio , Maeda Takuto , Mattei Elisabetta 
Published: February 2023

AbstractModelling the response of seismic wavefields to sharp lateral variations in crustal discontinuities is essential for seismic tomography application and path effects correction in earthquake source characterization. This is particularly relevant when wavefields cross back-arc oceanic basins, i.e. mixed continental-oceanic settings. High-frequency (>0.05 Hz) seismic waves resonate and get absorbed across these settings due to a shallow Moho, crustal heterogeneities, and energy leakage. Here, we provide the first high-frequency wave-equation model of full seismograms propagating through realistic 3D back-arc basins. Inversion by parameters trial based on correlation analyses identifies P-, S- and coda-wave as attributes able to estimate jointly 3D Moho variations, sediment thickness, and earthquake source characteristics using data from a single regional earthquake. We use as data waveforms produced by the Accumoli earthquake (Central Italy, 2016), propagating across the Southern Tyrrhenian basin and recorded across Southern Italy. The best model comprises a deep Moho ($$\sim$$
∼
18 km) in the middle of the basin and a crustal pinch with the continental crust in Sicily. The deep Moho corresponds to the Issel Bridge, a portion of continental crust trapped between the Vavilov and Marsili volcanic centres. The Accumoli earthquake is optimally described at a depth of 7.3 km using a boxcar with rise time of 6 s. Our results show that the early S-wave coda comprises trapped and reverberating phases sensitive to crustal interfaces. Forward modelling these waves is computationally expensive; however, adding these attributes to tomographic procedures allows modelling both source and structural parameters across oceanic basins.
Real-World Evidence of Tolerability of 20% Subcutaneous Immunoglobulin Treatment
Authors: Rosenbach Kevin , Park Michelle , Sanchirico Marie , Nwose Oliseyenum , Paris Kenneth 
Published: February 2023

Abstract
Purpose
The safety and efficacy of subcutaneous immune globulin 20% (human) solution (Ig20Gly) were demonstrated in clinical trials. However, real-world evidence of the tolerability of self-administered Ig20Gly in elderly patients is lacking. We describe real-world patterns of Ig20Gly usage for 12 months in patients with primary immunodeficiency diseases (PIDD) in the USA.

Methods
This retrospective chart review of longitudinal data from 2 centers included patients aged ≥ 2 years with PIDD. Ig20Gly administration parameters, tolerability, and usage patterns were assessed at initial and subsequent 6- and 12-month infusions.

Results
Of 47 enrolled patients, 30 (63.8%) received immunoglobulin replacement therapy (IGRT) within 12 months before starting Ig20Gly, and 17 (36.2%) started IGRT de novo. Patients were predominantly White (89.1%), female (85.1%), and elderly (aged > 65 years, 68.1%; median age = 71.0 years). Most adults received at-home treatment during the study, and most self-administered at 6 months (90.0%) and 12 months (88.2%). Across all time points, infusions were administered at a mean rate of 60–90 mL/h/infusion, using a mean of 2 sites per infusion, on a weekly or biweekly frequency. No emergency department visits occurred, and hospital visits were rare (n = 1). Forty-six adverse drug reactions occurred in 36.4% of adults, mostly localized site reactions; none of these or any adverse events led to treatment discontinuation.

Conclusion
These findings demonstrate tolerability and successful self-administration of Ig20Gly in PIDD, including elderly patients and patients starting IGRT de novo.
Point of care transthoracic echocardiography for the prediction of post – spinal anesthesia hypotension in elderly patients with cardiac diseases and left ventricular dysfunction
Authors: Moschovaki Nefeli , Saranteas Theodosios , Spiliotaki Elen , Giannoulis Dimitrios , Anagnostopoulos Dimitrios , Talliou Christina , Milionis Orestis , Briassoulis Panagiotis , Katogiannis Konstantinos , Papadimos Thomas 
Published: February 2023

AbstractIn elderly patients with cardiac diseases, changes in cardiovascular physiology diminish cardiovascular reserve and predispose to hemodynamic instability after spinal anesthesia; hence, such patients could be at risk of postoperative complications. Additionally, transthoracic echocardiography (TTE) is used in clinical practice to evaluate cardiovascular hemodynamics. Therefore, we hypothesized that echocardiographic measurements could display significant diagnostic power in the prediction of post - spinal anesthesia hypotension in elderly patients with cardiac diseases and reduced left ventricular ejection fraction (LV-EF). Therefore, sixty-one elderly orthopedic-trauma patients were recruited. Prior to spinal anesthesia a TTE examination was performed. The LV-EF, the stroke volume index (SVI), the peripheral vascular resistance (PVR), the LV filling pressures (E/Em ratio), the right ventricular function [tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (TASV) and fractional area change (FAC)], as well as inferior vena cava (IVC) measurements, such as IVCCI (collapsibility index of the IVC) and dIVCmax (maximum diameter of IVC)-to-IVCCI ratio were assessed. Twenty-six out of sixty-one patients manifested hypotension. Preoperative dIVCmax-to-IVCCI ratio demonstrated the greatest performance amongst echocardiographic indices in predicting post - spinal anesthesia hypotension. The dIVCmax-to-IVCCI ratio < 48 had significantly higher diagnostic power than IVCCI > 0.28, FAC > 42, E/Em ratio < 9 and SVI < 32 (receiver operator characteristic curve analysis). The gray zone for the dIVCmax-to-IVCCI ratio (40–49) showed the lowest number of inconclusive measurements among echocardiographic variables. The preoperative dIVCmax-to-IVCCI ratio could be a reliable echocardiographic index to predict post - spinal anesthesia hypotension in elderly patients with left ventricular dysfunction.
Web-Based Cognitive-Behavioral Therapy to Reduce Severe Cancer-Related Fatigue Among Survivors of Hodgkin Lymphoma: A Feasibility Study
Authors: Esser Peter , Müller Horst , Borchmann Peter , Kreissl Stefanie , Knoop Hans , Platzbecker Uwe , Vucinic Vladan , Mehnert-Theuerkauf Anja 
Published: February 2023

AbstractWe investigated the feasibility of a web-based cognitive-behavioral therapy to reduce cancer-related fatigue (CRF) among survivors of Hodgkin lymphoma. In this before-and-after trial, patients were primarily recruited via the German Hodgkin Study Group (GHSG). We assessed feasibility (response and drop-out rate) and preliminary efficacy including CRF, quality of life (QoL), and depressive symptomatology.Ttests compared baseline levels with t1 (post treatment) and t2 (3 months of follow-up). Among 79 patients contacted via the GHSG, 33 provided interest (42%). Among the seventeen participants, four were treated face-to-face (pilot patients), 13 underwent the web-based version. Ten patients completed the treatment (41%). Among all participants, CRF, depressive symptomatology, and QoL improved at t1 (p ≤ .03). The effect in one of the CRF measures remained at t2 (p = .03). Except for QoL, post-treatment effects were replicated among the completers of the web-based version (p ≤ .04). The potential for this program has been demonstrated, but needs to be re-assessed after identified issues on feasibility have been resolved.Trial registration: The study was registered at ClinicalTrials.gov (Number: NCT03968250).