bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Sistem Pelaksanaan Program Imunisasi Dasar Lengkap Pada Bayi Di Puskesmas Kabupaten Pangkajene dan Kepulauan
Authors: Islam Nurul , Ella Andayanie  , Andi Surahman Batara  
Published: July 2023

Menurut World Health Organization (WHO) sekitar 1,5 juta anak mengalami kematian tiap tahunnya karena penyakit yang dapat dicegah dengan imunisasi. Pada 2018, terdapat kurang lebih 20 juta anak tidak mendapatkan imunisasi lengkap dan bahkan ada anak yang tidak mendapatkan imunisasi sama sekali. Penelitian ini bertujuan untuk mengetahui gambaran sistem pelaksanaan program imunisasi dasar lengkap pada bayi di Kabupaten Pangkep tahun 2021. Jenis penelitian ini menggunakan penelitian kuantitatif menggunakan pendekatan deskriptif. pengambilan sampel menggunakan metode total sampling, yaitu seluruh pegawai bagian imunisasi di setiap puskesmas menggunakan kuesioner. Hasil penelitian ini menunjukkan bahwa indikator input dalam aspek sumber daya manusia saat awal masa pandemic COVID-19 petugas lebih dialihkan pada penganan COVID-19, penyaluran pendanaan belum berjalan dengan lancar, sarana dan prasarana sudah berjalan dengan baik. Indikator seperti perencanaan dilakukan secara rutin, pelaksanaan imunisasi juga telah dilakukan sesuai jadwal, persiapan yang dilakukan petugas juga sudah berjalan dengan baik, koordinasi yang dilakukan terhadap lintas sektor juga berjalan dengan baik, dan evaluasi yang dilakukan juga berjalan dengan lancar. Indikator output yang meliputi cakupan imunisasi dasar lengkap masih ada beberapa puskesmas yang belum mencapai terget imunisasi dasar lengkap.
Gambaran Efek Samping Vaksin Sinovac Pada Masyarakat Di Wilayah Kerja Puskesmas Tamalanrea Kota Makassar
Authors: Rahmawati Nindita , Fatmah Afrianty Gobel  , Sumiaty  
Published: July 2023

Indonesia telah menggunakan 3 jenis vaksin salah satunya adalah vaksin Sinovac. Vaksin Sinovac adalah vaksin untuk mencegah infeksi virus SARS-CoV-2 atau COVID-19. Vaksinasi dosis 1 di Provinsi Sulewesi Selatan. Pada bulan Desember 2021, telah mencapai 51,63%. Angka ini setara dengan 3,64 juta peserta vaksin. Sementara untuk vaksinasi dosis 2 hingga kemarin telah tercapai 33,57% dari target. Tujuan Penelitian yaitu untuk mendapatkan informasi mengenai efek samping dari vaksin sinovac pada masyarakat di Puskesmas Tamalanrea Kota Makassar. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan pendekatan kuantitatif. Pengambilan sampel dilakukan secara Systematic sampling yaitu 107 orang dengan kriteria, yaitu: Tercatat sebagai paserta mengikuti vaksinasi di Puskesmas Tamalanrea (warga Tamalanrea), Sudah melakukan vaksinasi, memiliki sertifikat vaksinasi, dan bersedia menjadi responden dalam penelitian ini. Analisis data menggunakan analisis univariat dengan menggunakan program Ms Excel dan SPSS. Hasil penelitian ini menunjukkan bahwa responden memiliki pengetahuan “cukup” sebanyak 78 orang (72,9%) dan yang memiliki pengetahuan “Kurang” sebanyak 29 orang (27,1%). Jenis efek samping yang diderita responden terbanyak yaitu: nyeri dibahu tempat suntikan (85%), nyeri pada otot (62,6%), mengantuk (68,2%), dan perubahan nafsu makan (43,9%), kelelahan (45,8%), dan tidak enak badan (42,1%). Seperti semua vaksin pada umumnya, vaksin Covid-19 dapat menyebabkan efek samping yang sebagian besar ringan atau sedang dan hilang dengan sendirinya dalam beberapa hari.
Gambaran Penerapan Protokol Kesehatan Di Kantor Kelurahan Benteng Kabupaten Wajo
Authors: Aulia Annisa  , Rusydi Arni Rizqiani , Ella Andayanie  
Published: July 2023

Coronavirus adalah virus jenis baru yang telah berhasil menginfeksi ribuan juta masyarakat global dalam waktu yang sangat singkat. Berdasarkan data pantauan Covid-19 di kecamatan pitumpanua yaitu terdiri dari 190 orang yaitu isolasi 10 orang, dirawat 0 orang, sembuh 177 orang dan meninggal 3 orang. Jenis penelitian yang digunakan adalah menggunakan metode kuantitatif dengan pendekatan deskriptif dan menggunakan skala likert. Dengan sampel sebanyak 35 orang dengan secara Accidental sampling. Hasil penelitian berdasarkan aspek penggunaan masker pelindung wajah tergolong baik sebanyak 25 masyarakat (71,4%), aspek mencuci tangan tergolong baik sebanyak 29 masyarakat sebanyak (82,9%), aspek penggunaan hand sanitizer tergolong cukup baik sebanyak 19 masyarakat (54,3%), aspek jaga jarak tergolong cukup baik sebanyak 20 masyarakat (57,2%), aspek etika batuk dan bersin tergolong baik sebanyak 29 masyarakat (82,9%), aspek isolasi mandiri tergolong baik sebanyak 22 masyarakat (62,9%) dan aspek menjaga kesehatan tergolong baik sebanyak 24 masyarakat (68,6%). Adapun saran yang ingin disampaikan peneliti yaitu diharapkan tetap mengikuti protokol kesehatan pencegahan virus corona kepada masyarakat dan instansi saat melakukan pelayanan.
Gambaran Kesehatan Mental Perawat di Ruang Rawat Inap RSUD Labuang Baji Makassar Tahun 2022
Authors: Devi Lupianti  , Andi Multazam  , Ella Andayanie  
Published: July 2023

Kesehatan Mental merupakan dimana kondisi seseorang yang dibentuk atau dibuat oleh keadaan atau peristiwa di masa lalu. Jika peristiwa itu menyenangkan maka kesehatan mental akan terjaga dengan baik, tetapi jika peristiwa itu tidak menyenangkan bahkan sampai memunculkan trauma maka kesehatan mental akan terganggu. Berbagai jenis gangguan mental diantaranya kecemasan, stres dan depresi. Adapun tujuan penelitian Untuk mengetahui gambaran kesehatan mental tenaga perawat di Ruang Rawat Inap di RSUD Labuang Baji Makassar. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan menggunakan pendekatan kuantitatif. Jumlah sampel yang digunakan adalah sebanyak 117 sampel. Teknik pengambilan sampel adalah Purposive Sampling. Analisis data dilakukan dengan tujuan agar memperoleh gambaran dari hasil penelitian. Hasil kesimpulan dari penelitian ini menunjukkan bahwa gambaran kesehatan mental perawat diruang rawat inap RSUD Labuang Baji Makassar tingkat kecemasan cenderung mengalami kecemasan sedang 71 orang (60,7%), mayoritas perawat cenderung mengalami stres pada tingkat ringan 117 orang (100,0%), sedangkan yang mengalami depresi cenderung pada tingkat ringan 60 orang (51,3%). Adapun saran terkait dengan penelitian ini yaitu RSUD Labuang Baji Makassar disarankan bagian manajemen rumah sakit perlu melakukan program sharing, manajemen kelelahan diagendakan oleh kepala ruang rawat inap.
Studi Spasial Determinan Kejadian Covid-19 Di Wilayah Kerja Puskesmas Sudiang Raya
Authors: Irfansyah Andi Farid , Abbas Hasriwiani Habo , Yusriani  
Published: July 2023

Kasus Covid-19 menurut data Dinas Kesehatan Kota Makassar yang ditemukan dan ditangani pada tahun 2021 sebanyak 57.190 orang, tertinggi berada di Kecamatan Biringkanaya. Usia produktif rentan terhadap Covid-19. Penelitian ini bertujuan untuk mengetahui distribusi spasial determinan kejadian Covid-19 di wilayah kerja Puskesmas Sudiang Raya Tahun 2022. Jenis penelitian yang digunakan adalah kuantitatif dengan desain penelitian deskriptif dan pendekatan spasial. Populasi adalah jumlah kasus Covid-19 yang berada di Kelurahan Sudiang Raya dan Laikang. Sampel adalah jumlah penderita Covid-19 pada bulan april – mei dengan menggunakan teknik purposive sampling, sebanyak 126 kasus. Hasil penelitian diperoleh data dari penderita Covid-19 yaitu ditemukan 14 orang penyintas Covid-19, data umur dewasa 20-45 tahun diperoleh 66 orang, jenis kelamin perempuan diperoleh 69 orang, pendidikan D3/D4/S1/Sederajat diperoleh 66 orang, pekerjaan ASN/PNS diperoleh 27 orang. Adapun Vaksinasi, jenis vaksin tertinggi sinovac diperoleh 86 orang, status vaksinasi kategori vaksin tidak lengkap diperoleh 88 orang. Demikian perilaku 5m yaitu, ditemukan 71 orang memakai masker, 106 orang mencuci tangan, 73 orang menjaga jarak, 94 orang menjauhi kerumunan dan 75 orang Tidak membatasi mobilitas dan interaksi. Kesimpulan dari penelitian yaitu berdasarkan umur, mayoritas masyarakat berusia dewasa 20-45 tahun, jenis kelamin terbanyak perempuan, tingkat pendidikan lebih tinggi D3/D4/S1/Sederajat, pekerjaan masyarakat dominan sebagai ASN/PNS. Adapun perilaku 5M, dalam kategori memakai masker, mencuci tangan, menjaga jarak, menjauhi kerumunan dan masyarakat pada penelitian ini tidak membatasi mobilitas dan interaksi. Penelitian ini menyarankan agar pemerintah setempat dan puskesmas secara kooperatif memberikan penyuluhan dan sosialisasi terkait pencegahan Covid-19.
Stable and low-threshold photon upconversion in nondegassed water by organic crystals
Authors: Murakami Yoichi , Enomoto Riku 
Published: July 2023

Photon upconversion (UC) is a technology that converts lower-energy photons (longer wavelength light) into higher-energy photons (shorter wavelength light), the opposite of fluorescence. Thus, UC is expected to open a vast domain of photonic applications that are not otherwise possible. Recently, UC by triplet−triplet annihilation (TTA) between organic molecules has been studied because of its applicability to low-intensity light, although the majority of such studies have focused on liquid samples in the form of organic solvent solutions. To broaden the range of applications, solid-state UC materials have been an active area of research. We recently developed air-stable, high-performance molecular UC crystals that utilize a stable solid-solution phase of bicomponent organic crystals. This article begins with a brief overview of previous challenges in developing and improving solid-state TTA–UC materials. Then, we briefly review and explain the concept as well as advantages of our molecular solid-solution UC crystals. We applied these organic crystals for the first time to a water environment. We observed blue UC emission upon photoexcitation at 542 nm (green–yellow light) and then measured the excitation intensity dependence as well as the temporal stability of the UC emission in air-saturated water. In nondegassed water, these organic crystals were stable, functioned with a low excitation threshold intensity of a few milliwatts per square centimeter, and exhibited high photo-irradiation durability at least over 40 h; indicating that the developed organic crystals are also viable for aqueous conditions. Therefore, the organic crystals presented in this report are expected to extend the domain of UC-based photonic applications in practical water systems including in vivo diagnostic, clinical, and therapeutic applications.
Safety and performance of the Vienna self-expandable transcatheter aortic valve system: 6-month results of the VIVA first-in-human feasibility study
Authors: Briedis Kasparas , Mizariene Vaida , Rumbinaite Egle , Jurenas Martynas , Aldujeli Ali , Briede Kamilija , Jakuska Povilas , Jankauskas Antanas , Ceponiene Indre , Lenkutis Tadas , Zaliunas Remigijus , Benetis Rimantas 
Published: July 2023

BackgroundThe novel Vienna TAVI system is repositionable and retrievable, already pre-mounted on the delivery system, eliminating the need for assembly and crimping of the device prior to valve implantation.AimsThe purpose of this first-in-human feasibility study was to determine the safety, feasibility, clinical and hemodynamic performance of the Vienna TAVI system at 6-month follow-up. (ClinicalTrials.gov identifier NCT04861805).MethodsThis is a prospective, non-randomized, single-arm, single-center, first-stage FIH feasibility study, which is followed by a second-stage pivotal, multicenter, multinational study in symptomatic patients with severe aortic stenosis (SAS). The first-stage FIH study evaluated the safety and feasibility, clinical and hemodynamic performance of the device in 10 patients with SAS based on recommendations by the VARC-2.ResultsAll patients were alive at 3-month follow-up. 1 non-cardiovascular mortality was reported 5 months after implantation. There were no new cerebrovascular events, life-threatening bleeding or conduction disturbances observed at 6-month follow-up. The mean AV gradient significantly decreased from 48.7 ± 10.8 to 7.32 ± 2.0 mmHg and mean AVA increased from 0.75 ± 0.18 to 2.16 ± 0.42 cm2 (p &lt; 0.00001). There was no incidence of moderate or severe total AR observed. In the QoL questionnaires, the patients reported a significant improvement from the baseline 12-KCCQ mean score 58 ± 15 to 76 ± 20. NYHA functional class improved in two patients, remained unchanged in one patient. There was an increase in mean 6-min-walk distance from baseline 285 ± 97 to 347 ± 57 m.ConclusionsThis study demonstrates that using Vienna TAVI system has favourable and sustained 6-month safety and performance outcomes in patients with symptomatic severe aortic stenosis.
Dynamic response of large-section inclined shallow-buried pipe tunnel under train loads
Authors: Cui Guo-Jing , Xie Jiang-Sheng , Sun Yin-hao , Tian Xiao-xu , Meng Chen 
Published: July 2023

To ensure the normal passage of an ascending road during the construction of a pipe-jacking tunnel, trains generally run at low speeds during the construction phase and adopt normal speeds later. Using Jingjiu Road, Xi’an, China, as an engineering case, this study evaluated and predicted the dynamic response of a tunnel structure and soil mass when trains run at low to normal speeds. When the train speed was controlled in the range of 30–60 km/h, the soil deformation change rate around the shallow-buried pipe-jacking tunnel was 0.41%. The maximum tensile stress growth rate of the pipe-jacking tunnel structure was 0.037%, the maximum compressive stress growth rate was 0.128%, and the maximum increase in the stress of the pipe-jacking structure was 1.82%. Thus, the soil and structure of the pipe-jacking tunnel were in a safe-stress state. The results show that the influence of train speed on soil and structural stress is small and can be ignored.
Clinical and mutational spectrum of paediatric Charcot-Marie-Tooth disease in a large cohort of Chinese patients
Authors: Ma Yan , Duan Xiaohui , Liu Xiaoxuan , Fan Dongsheng 
Published: July 2023

Background: Charcot-Marie-Tooth disease (CMT) is the most common inherited neurological disorder suffered in childhood. To date, the disease features have not been extensively characterized in the Chinese paediatric population. In this study, we aimed to analyse the clinical profiles and genetic distributions of a paediatric CMT cohort in China.Methods: A total of 181 paediatric CMT patients were enrolled. After preexcluding PMP22 duplication/deletion by multiplex ligation-dependent probe amplification (MLPA), Sanger sequencing, targeted next-generation sequencing (NGS) or whole-exome sequencing (WES) was performed to obtain a genetic diagnosis. Detailed information was collected to explore the spectrum of subtypes and genotype-phenotype correlations.Results: Pathogenic mutations were identified in 68% of patients in this study; with PMP22 duplication, MFN2 and GJB1 were the most frequent disease-causing genes. Of note, respect to the higher prevalence worldwide, CMT1A (18.2%) was relatively lower in our cohort. Besides, the mean age at onset (8.3 ± 5.7 years) was significantly older in our series. In genotype-phenotype analyse, PMP22 point mutations were considered the most severe genotypes and were mostly de novo. In addition, the de novo mutations were identified in up to 12.7% of all patients, which was higher than that in other studies.Conclusion: We identified a relatively lower detection rate of PMP22 duplication and a higher frequency of de novo variants among paediatric patients in China. We also identified the genetic and phenotypic heterogeneity of this cohort, which may provide clues for clinicians in directing genetic testing strategies for Chinese patients with early-onset CMT.
Oxidative stress genes define two subtypes of triple-negative breast cancer with prognostic and therapeutic implications
Authors: Liu Shenting , Xu He , Feng Ying , Kahlert Ulf D. , Du Renfei , Torres-de la Roche Luz Angela , Xu Kai , Shi Wenjie , Meng Fanshuai 
Published: July 2023

Introduction: Oxidative stress (OS)-related genes have been confirmed to be closely related to the prognosis of triple-negative breast cancer (TNBC) patients; despite this fact, there is still a lack of TNBC subtype strategies based on this gene guidance. Here, we aimed to explore OS-related subtypes and their prognostic value in TNBC.Methods: Data from The Cancer Genome Atlas (TCGA)-TNBC and Sequence Read Archive (SRA) (SRR8518252) databases were collected, removing batch effects using a combat method before analysis. Consensus clustering analysis identified two OS subtypes (clusters A and B), with cluster A showing a better prognosis. Immune infiltration characteristics were analyzed using ESTIMATE and single-sample gene set enrichment analysis (ssGSEA) algorithms, revealing higher ImmuneScore and ESTIMATEscore in cluster A. Tumor-suppressive immune cells, human leukocyte antigen (HLA) genes, and three immune inhibitors were more prevalent in cluster A.Results: An eight-gene signature, derived from differentially expressed genes, was developed and validated as an independent risk factor for TNBC. A nomogram combining the risk score and clinical variables accurately predicted patient outcomes. Finally, we also validated the classification effect of subtypes using hub markers of each subtype in the test dataset.Conclusion: Our study reveals distinct molecular clusters based on OS-related genes to better clarify the reactive oxygen species (ROS)-mediated progression and the crosstalk between the ROS and tumor microenvironment (TME) in this heterogenetic disease, and construct a risk prognostic model which could provide more support for clinical treatment decisions.
Efficacy and safety of Nirmatrelvir/Ritonavir for treating the Omicron variant of COVID-19
Authors: Qiu Chaochao , Wu Zhengxing , Liu Xiaojing , Zhang Qiang , Wu Lianpeng , Ye Xinchun , Zhou Jiajun , Shi Jichan , Jiang Xiangao 
Published: July 2023

ObjectiveTo evaluate the efficacy and safety of Nirmatrelvir/Ritonavir in the treatment of the Omicron variant of coronavirus disease 2019 (COVID-19).MethodsData from 58 patients who were infected with the Omicron variant of COVID-19 were retrospectively collected. The patients were divided into two groups according to the treatment regimen they received. Patients in both groups were given Lianhua Qingwen capsules orally, three times/day, 6 g/time. The study group was given Nirmatrelvir 300 mg/Ritonavir 100 mg orally, q12h, for 5 days, and the control group was not given any antiviral drugs. The two groups were compared in terms of the change in computed tomography (CT) values of COVID-19 nucleic acid, the negative conversion time of COVID-19 RNA, hospitalization time, adverse drug reactions and COVID-19 nucleic acid re-positive tests.ResultsThe time to increase the CT values in the study group was faster than that in the control group, and the CT values in the study group were significantly larger than in the control group on days four and seven (p &lt; 0.05); The negative conversion time in the study group was shorter than the control group (Z = –2.424, p = 0.015), and the hospitalization time was also shorter (Z = –2.603, p = 0.009). There were no statistically significant adverse drug reactions during hospitalization in both groups (χ2 = 2.747, p = 0.097). None of the study group tested re-positive for SARS-CoV-2 nucleic acid after discharge.ConclusionThe efficacy of Nirmatrelvir/Ritonavir in the treatment of the Omicron variant of COVID-19 was positive and had good tolerance in patients.
Mendelian randomization study reveals the effect of idiopathic pulmonary fibrosis on the risk of erectile dysfunction
Authors: Zhang Kun , Zhou Jiejun , Li Anqi , Chen Mingwei 
Published: July 2023

BackgroundSeveral studies have found that erectile dysfunction (ED) is associated with interstitial lung disease. However, the causal relationship between idiopathic pulmonary fibrosis (IPF) and ED risk remains unclear. The present two-sample Mendelian randomization (MR) study aimed to reveal the causal effect of IPF on ED risk.MethodsThis study included two GWAS summary statistics of IPF (1,028 cases and 196,986 controls) and ED (6,175 cases and 217,630 controls) of European ancestry. The inverse-variance weighted (IVW) was applied as the primary method, and MR-Egger, weighted median, weighted mode, and simple mode were applied as complementary methods to estimate the causal impact of IPF on ED risk. The MR-PRESSO global test and MR-Egger regression were applied to evaluate the pleiotropy. The Cochran’s Q test was applied to examine heterogeneity. The leave-one-out analysis ensured the robustness and reliability of the results.ResultsTwenty-one genetic variants were obtained as IPF instrumental variables without pleiotropy and heterogeneity. MR analysis using the IVW showed a potential causal relationship between IPF and increased ED risk (ORIVW = 1.046, 95% CI: 1.020–1.073, p = 0.001), and consistent results were obtained with MR-Egger, weighted median, and weighted mode. The leave-one-out analysis showed that no instrumental variables unduly influenced the results.ConclusionThis study suggested that IPF may increase the ED risk of the European population.
Differences in the lipid metabolism profile and clinical characteristics between eosinophilic and non-eosinophilic acute exacerbation of chronic obstructive pulmonary disease
Authors: Wang Yating , Chang Chun , Tian Sifan , Wang Juan , Gai Xiaoyan , Zhou Qiqiang , Chen Yahong , Gao Xu , Sun Yongchang , Liang Ying 
Published: July 2023

Objective: In this study, we aimed to investigate the differences in serum lipid metabolite profiles and their relationship with clinical characteristics between patients with eosinophilic and non-eosinophilic AECOPD.Methods: A total of 71 AECOPD patients were enrolled. Eosinophilic AECOPD was defined as blood EOS% ≥ 2% (n = 23), while non-eosinophilic AECOPD, as blood EOS&lt; 2% (n = 48). Clinical data were collected, and serum lipid metabolism profiles were detected by liquid chromatography–mass spectrometry (LC-MS). The XCMS software package was used to pre-process the raw data, and then, lipid metabolite identification was achieved through a spectral match using LipidBlast library. Differences in lipid profiles and clinical features between eosinophilic and non-eosinophilic groups were analyzed by generalized linear regression. The least absolute shrinkage and selection operator (LASSO) was applied to screen the most characteristic lipid markers for the eosinophilic phenotype.Results: Eosinophilic AECOPD patients had less hypercapnic respiratory failures, less ICU admissions, a shorter length of stay in the hospital, and a lower fibrinogen level. In the lipid metabolism profiles, 32 significantly different lipid metabolites were screened through a t-test adjusted by using FDR (FDR-adjusted p &lt; 0.05 and VIP&gt; 1). Nine differential lipid metabolites were found to be associated with the three clinical features, namely, hypercapnia respiratory failure, ICU admission, and fibrinogen in further integration analysis. The species of triacylglycerol (TAG), phosphatidylcholine (PC), lysophosphatidylcholine (LPC), and diacylglyceryl trimethylhomoserine (DGTS) were high in these eosinophilic AECOPD. The LASSO was applied, and three lipid metabolites were retained, namely, LPC (16:0), TAG (17:0/17:2/17:2), and LPC (20:2). The logistic regression model was fitted using these three markers, and the area under the ROC curve of the model was 0.834 (95% CI: 0.740–0.929).Conclusion: Patients with eosinophilic AECOPD had a unique lipid metabolism status. Species of TAGs and LPCs were significantly increased in this phenotype and were associated with better clinical outcomes.