bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unstructured Parental Feedback at A Tertiary Maternity Hospital: A Cohort Study Using Routinely Collected Health Data
Authors: Abdel‐Latif Mohamed E. , Cheng Junyu , Todd David A. , Davis Deborah , Alzahrani Naif , Carlisle Hazel , Hussain Rafat 
Published: January 2025

ABSTRACTBackgroundHospital care for neonates can be challenging for parents, and a negative parental experience can affect the well‐being of the infant after discharge. A family‐centred approach is the gold standard of care in neonatology.AimThis study aimed to identify common themes in voluntary unstructured feedback received from parents and caregivers of infants admitted to the neonatal intensive care unit, special care nursery or postnatal ward or followed up by neonatal outpatient services at a tertiary Australian Women and Children's Hospital. These findings are intended to inform the development of effective family‐centred neonatal care approaches.MethodsThis single‐centre observational study used routinely collected unstructured parental voluntary feedback received between 2010 and 2021. All feedback is entered prospectively in the online consumer feedback module of a reporting database (RiskMan). Deductive thematic analysis (whereby themes, codes and categories were chosen prior to the analysis) was used to analyse the extracted quotations.ResultsDuring the study period, 3533 unstructured feedback items were received. Most of the feedback received was compliments (2725/3533, 77.1%). The main feedback category was ‘staff competency and efficiency’, which accounted for 80.8% (2201/2755) of the compliments and 45.0% (364/808) of the complaints. Most complaints were from outpatient services and postnatal wards and centred around ‘infrastructure and systems’ (280/808, 34.7%) and ‘information, explanation and communication’ (152/808, 18.8%).ConclusionsParental satisfaction was positively affected by ‘staff competency and efficiency’. This study supports collecting and analysing unstructured feedback to reflect parental experiences and drive quality improvement.
Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review
Authors: Wang Linbao , Luo Yunzhuan , Qiu Xing , Cheng Liangliang , Ma Kaiming , Guan Jianchen , Liu Yuchen , Ying Jiawei , Zhao Dewei 
Published: January 2025

ABSTRACTTraumatic osteonecrosis of the femoral head (TONFH) refers to ischemic osteonecrosis is resulting from an acute mechanical interruption of the blood supply to the femoral head. The early diagnosis and optimal treatment have been central focuses of research and continue to undergo improvement. Reliable animal models are essential for advancing research into the treatment of the disease. This review aims to provide a comprehensive overview of tetrapod models (rats, rabbits, dogs, and sheep) and bipod models (emus, ostriches), as well as various modeling methods (traumatic hip dislocation, dissection of the round ligament and ligature of the femoral neck, femoral neck fracture (FNF), reduction and internal fixation after femoral neck fracture, and highly selective disruption of the anterior‐superior retinacular vessels). This review examines the advantages, disadvantages, and applicability of each model. Based on blood flow analysis, it proposes a more reliable direction for TONFH modeling: simulating partial blood flow injury in the context of FNF.
Free to Build: Liberty and Urban Housing
Authors: Christmas Billy 
Published: January 2025

ABSTRACTMost large cities of the world's most affluent countries are increasingly unaffordable in ways that raise serious normative questions. The price of purchasing and renting housing is relatively high due to political constraints on supply. These constraints do not protect the normative interests of residents of these cities, and generate a system in which development that would be mutually beneficial is prohibited. I argue that rights over commonly used urban space have the same liberty‐based justification as traditional private property rights. And that assigning rights over the disposition of common space to those most local to it, to use, develop, or transfer as they collectively wish, would overcome the problem. It would do so by enabling an expansion of housing supply where it is most needed, but only through a procedure that ensures it will benefit local residents, by their own lights.
Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates
Authors: Sun Hongjing , Kim Michele M. , Ong Yi Hong , Dimofte Andreea , Singhal Sunil , Busch Theresa M. , Cengel Keith A. , Zhu Timothy C. 
Published: January 2025

AbstractPhotodynamic therapy (PDT) has shown promise as an adjuvant treatment for malignant pleural mesothelioma when combined with surgical resection. Accurate light dosimetry is critical for treatment efficacy. This study presents an improved method for analyzing light fluence distribution in pleural PDT using a standardized anatomical coordinate system and advanced computational modeling. We utilized an infrared navigation system with an improved treatment delivery wand to track light delivery in real‐time. The human chest cavity geometry was reconstructed and the pleura was mapped to a standardized coordinate system, allowing for direct comparisons across patients. Light fluence was calculated using both primary and scattered components, with a novel dual correction method applied to match measured values at detector locations. The standardized approach allowed for statistical analysis of light fluence distribution across anatomical regions in a cohort of 11 patients. Results showed acceptable light fluence uniformity with a standard deviation of 6.6% from the prescribed dose across patients. This comprehensive analysis provides insights for optimizing treatment protocols and lays the groundwork for future studies on singlet oxygen generation and its correlation with treatment outcomes in pleural PDT.
Effects of photobiomodulation therapy (660‐nm laser) on median nerve function in Wistar rats
Authors: Ferreira Marcílio Coelho , Xavier Diego Mendes , Lamas Giovanna Moura Della Santa , Barbosa Samara Maria Neves , Ferreira Sheyla Gabrielle Alves , Gaiad Thaís Peixoto , Santos Ana Paula , Oliveira Murilo Xavier 
Published: January 2025

AbstractThis study investigates the effects of photobiomodulation (PBM) with a 660‐nm laser on nerve regeneration and muscle morphometry following median nerve axonotmesis in rats. Sixteen Wistar rats were divided into a control group and laser‐treated group, with the latter receiving 10 applications of PBM (660 nm; 20 mW; 10 J/cm2; 0.4 J; and 20 s) over 2 weeks. Functional analysis was performed using the grasping test, which measures the grip strength of the forelimb digits to evaluate motor function of the median nerve. Morphometric analyses were conducted on the median nerve, flexor digitorum (FD) muscle, and flexor carpi radialis (FCR) muscle. PBM led to functional improvement, with significant differences observed on the 21st day post‐injury. However, no significant differences between groups were found in nerve morphometry. Morphometric analysis of the FD muscle revealed significant improvements in the PBM group, but with no significant differences regarding the FCR muscle. These findings suggest that 660‐nm laser with the parameters used produced functional improvement as well as significant improvements in the morphometry of the FD muscle, but did not have significant effects on the morphometry of the FCR muscle or nerve regeneration.
Periodontal response to nonsurgical accelerated orthodontic tooth movement
Authors: Oner Fatma , Kantarci Alpdogan 
Published: January 2025

AbstractTooth movement is a complex process involving the vascularization of the tissues, remodeling of the bone cells, and periodontal ligament fibroblasts under the hormonal and neuronal regulation mechanisms in response to mechanical force application. Therefore, it will inevitably impact periodontal tissues. Prolonged treatment can lead to adverse effects on teeth and periodontal tissues, prompting the development of various methods to reduce the length of orthodontic treatment. These methods are surgical or nonsurgical interventions applied simultaneously within the orthodontic treatment. The main target of nonsurgical approaches is modulating the response of the periodontal tissues to the orthodontic force. They stimulate osteoclasts and osteoclastic bone resorption in a controlled manner to facilitate tooth movement. Among various nonsurgical methods, the most promising clinical results have been achieved with photobiomodulation (PBM) therapy. Clinical data on electric/magnetic stimulation, pharmacologic administrations, and vibration forces indicate the need for further studies to improve their efficiency. This growing field will lead to a paradigm shift as we understand the biological response to these approaches and their adoption in clinical practice. This review will specifically focus on the impact of nonsurgical methods on periodontal tissues, providing a comprehensive understanding of this significant and understudied aspect of orthodontic care.
Between law and custom: praising the prince and representing subjecthood in early modern Venice☆
Authors: Florio Giovanni 
Published: January 2025

AbstractSince the early fifteenth century, cities under Venetian rule used to pay homage to each newly elected doge by means of ambassadors tasked with delivering congratulatory orations praising him. Historical sources describe this ceremonial as a custom (consuetudine), namely a long‐established practice acquiring force of law through its constant and uninterrupted observance by a community of individuals viewing it as mandatory. By promoting a closer analysis of both Venetian and local legislation on congratulatory embassies, this article questions this reading. The aim is to highlight the role of written legislation in shaping the rhetorical choices made by subject orators and in (re)defining the performative function fulfilled by the periodical homage paid to the republican prince.
A novel semiparametric approach to nonignorable missing data by catching covariate marginal information
Authors: Cheng Manli , Liu Yukun , Qin Jing 
Published: January 2025

AbstractNonignorable missing data problems are challenging because of the parameter identifiability issue. Existing methods designed for handling nonignorable missing data often struggle to fully utilize covariate marginal information, leading to potential efficiency losses. We propose a novel approach that leverages both a logistic propensity score model and a semiparametric proportional likelihood ratio model (SPLRM) for the observed data. Our approach generally does not require instrumental variables or shadow variables, leading to improved identifiability in most scenarios. In the identifiable case, we use the density‐ratio‐model‐based empirical likelihood to catch the covariate distribution information and estimate the target parameter. The proposed estimator is shown to be asymptotically normal and semiparametric efficient. In the exception case, we conduct a sensitivity analysis by making full use of the marginal covariate information. Our numerical results indicate that compared with existing estimators, the proposed estimator is more reliable and more robust to model mis‐specification.
Integrating Social Determinants With the Interpersonal Theory of Suicide in a Study of Bipolar Outpatients
Authors: Mulligan Daniel J. , Taylor Alexis , Lamis Dorian A. 
Published: January 2025

ABSTRACTIntroductionBipolar disorder, socioeconomic deprivation, and social isolation are major risk factors for suicide. The interpersonal theory of suicide (IPTS) posits perceived burdensomeness and thwarted belongingness as proximal causes of suicidal thoughts and behaviors, while the social determinants of health (SDOH) framework highlights distal socioeconomic factors. Studies of suicidality in bipolar disorder have used the IPTS and the SDOH framework, but few have integrated them to explore connections between distal and proximal factors.MethodsThis study examined perceived burdensomeness and thwarted belongingness as mediators of the relationship between cumulative socioeconomic risk and suicide risk. Participants were 171 outpatients in a United States (U.S.) bipolar clinic (mean age = 39.0, 69.6% female, 73.7% Black/African American).ResultsCumulative socioeconomic risk, perceived burdensomeness, and thwarted belongingness were positively associated with suicide risk. Perceived burdensomeness mediated the relationship between cumulative socioeconomic risk and suicide risk, but thwarted belongingness did not.ConclusionFindings broadly suggest the IPTS and the SDOH framework can be fruitfully integrated to guide research and prevent suicide. The pathway from cumulative socioeconomic risk to suicide risk via perceived burdensomeness warrants further attention, particularly for individuals diagnosed with bipolar disorder. Implications for future studies of the IPTS, SDOH, and suicidality are discussed.
Broad-spectrum applications of plant growth-promoting rhizobacteria (PGPR) across diverse crops and intricate planting systems
Authors: Zhang Shixiang , Li Fengmin , Chang Luyin , Zhang Qiyu , Zhang Zhenyu , Wu Tianci , Wu Yanlin , Wang Zhi , Su Yulong , Yang Xingyou , Gao Weichang , Li Mengsha , Wu Yue , Jiang Ying 
Published: January 2025

ABSTRACT

Multifunctional plant growth-promoting rhizobacteria (PGPR) have garnered significant attention in agricultural applications; however, a few have applied them in crop rotation or intercropping fields. To identify PGPR with strong colonization ability and broad spectrum benefit, we screened strains from the local tobacco rhizosphere and evaluated their growth-promoting effects across various crops and farming systems. In this study, strain L8, identified as
Bacillus thuringiensis
, was selected as a multifunctional PGPR capable of producing indole-3-acetic acid (IAA), solubilizing potassium, and mobilizing both organic and inorganic phosphorus. Compared with the control group, the soil treated with strain L8 in tobacco pot experiments showed significantly higher levels of IAA, available potassium, and available phosphorus. Furthermore, tobacco plants inoculated with L8 exhibited significantly improved growth parameters compared with the uninoculated control. The results indicated that compared with the control, strain L8 increased tobacco fresh weight (by 83.18%), plant height (by 29.32%), relative chlorophyll content (by 14.33%), as well as plant phosphorus (by 23.78%) and potassium (by 30.81%). Interestingly, L8 not only enhanced tobacco growth but also improved tobacco root morphology, significantly increasing root length (1.55-fold), root surface area (1.78-fold), and root volume (2.05-fold) compared with the control. These findings provide valuable insights into utilizing plant growth-promoting bacteria for tobacco production. Moreover, the inoculation strain L8 enriched soil organic matter and nutrient content in both wheat (
Triticum aestivum
)-maize (
Zea mays
) rotation and peanut (
Arachis hypogaea
)-maize intercropping systems. Furthermore, within the intricate tillage systems of wheat-corn rotation and peanut-corn intercropping, multifunctional PGPR strain L8 can play a crucial role in crop growth promotion, yield increase, and higher soil nutrient availability.

IMPORTANCE
These findings aim to study the application of plant growth-promoting rhizobacteria (PGPR) in diverse crops and complex planting systems, showing their adaptability and effectiveness in various agricultural contexts. The study suggests that this strain improves nutrient utilization in the soil, enhances soil health, and plays a significant role in plant growth through the secretion of substances like auxin (IAA). In parallel, we observed that applying this strain improved the production efficiency of wheat, corn, and peanuts within complex farming systems, indicating that this method holds the potential for enhancing both the yield and quality of various crops.
Mechanism of TGIF1 on glycolipid metabolism disorders in mice with type 2 diabetes
Authors: Bai Fuyan , Zheng Liping , Tao Li , Wang Shikai , Li Yuchen , Hou Lijun 
Published: January 2025

IntroductionType 2 diabetes (T2D) is a chronic condition characterized by high levels of blood glucose resulting from the inefficiency of insulin. This study aims to explore the mechanism of TGFB-induced factor homeobox 1 (TGIF1) in the glycolipid metabolism of mice with T2D.Research design and methodsMice with T2D were induced by high-fat diet and low-dose streptozotocin (STZ) injection. After TGIF1 was overexpressed in mice with T2D, the weight was monitored. The levels of fasting plasma glucose, fasting serum insulin, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured. Staining assays were performed to observe liver tissue pathology and lipid accumulation. Liver function and oxidative stress were measured. Palmitic acid (PA)-induced primary hepatocytes were used to establish cell models. After TGIF1 was overexpressed in the cells, cell viability, cellular glucose uptake and consumption, and intracellular glycogen content were detected. The expression of TGIF1, miR-106b-5p, and early growth response 2 (EGR2) was detected and their binding relationships were analyzed. Combined experiments were conducted to validate the mechanism.ResultsTGIF1 was downregulated in mice with T2D. TGIF1 overexpression reduced hyperglycemia and hyperlipidemia, improved insulin resistance, increased liver glycogen content, and attenuated lipid accumulation and glycolipid metabolism disorders in mice with T2D. TGIF1 was enriched on the miR-106b-5p promoter and promoted miR-106b-5p expression. miR-106b-5p inhibited EGR2 expression. miR-106b-5p inhibition or EGR2 overexpression partially reversed the alleviative effect of TGIF1 overexpression on glycolipid metabolism disorders.ConclusionTGIF1 reduces glycolipid metabolism disorders in mice with T2D through the miR-106b-5p/EGR2 axis.
Association between use of sodium-glucose co-transporter-2 inhibitor and the risk of incident dementia: a population-based cohort study
Authors: Abdullah Zarin , Cui Ying , Platt Robert W , Renoux Christel , Azoulay Laurent , Xia Chenjie , Yu Oriana Hoi Yun 
Published: January 2025

ObjectivesTo assess the association between sodium-glucose co-transporter-2 inhibitor (SGLT-2i) use and the risk of incident dementia compared with dipeptidyl peptidase-4 inhibitors (DPP-4i) use among individuals with type 2 diabetes.DesignA population-based retrospective cohort study.SettingThe Clinical Practice Research Datalink (CPRD) Aurum database from the UK.ParticipantsIndividuals with type 2 diabetes, aged 40 years or older, newly prescribed SGLT-2i or DPP-4i on or after 2013–2021, registered in the CPRD Aurum database.Main outcome measureThe primary outcome was incident dementia, and the secondary outcome was incident mild cognitive impairment (MCI). Cox proportional hazard models were used to estimate the HR and corresponding 95% CI for the primary and secondary outcomes. Propensity score fine stratification weights were used to adjust for confounding.ResultsAmong a cohort of 118 006 individuals, the incident rate (IR) of dementia was 0.56/1000 person-years over a median follow-up period of 1.54 years among SGLT-2i users compared with 2.67/1000 person-years in DPP-4i users, over a median follow-up period of 1.79 years. The adjusted HR for SGLT-2i use compared with DPP-4i use for dementia was 0.78 (95% CI 0.55 to 1.12), while for MCI was 0.86 (95% CI 0.80 to 0.92). The age-specific stratified analysis demonstrated the adjusted HR for SGLT-2i use compared with DPP-4i use for the risk of incident dementia among elderly, aged ≥65 years, was 0.50 (95% CI 0.31 to 0.80).ConclusionPrimary findings did not yield conclusive evidence to infer an association between SGLT-2i use and the risk of incident dementia.
Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol
Authors: Chen Ziwen , Xu Tao , Shu Yun-Jie , Zhou Xueli , Li Qifu , Guo Taipin , Liang Fan-Rong 
Published: January 2025

IntroductionPrimary hypertension (PH) affects over one billion individuals globally, yet less than 30% achieve controlled blood pressure (BP) with medication. Many patients require a combination of multiple medications to reach targets, but adverse effects and financial burdens undermine adherence. Additionally, prehypertension affects 25%–50% of adults, increasing the risk of cardiovascular complications. Early detection and management of prehypertension are crucial for delaying the need for pharmacological interventions. In recent years, clinical guidelines have increasingly emphasised non-pharmacological interventions for PH management. However, the diversity of non-pharmacological therapies and the inconsistencies in efficacy challenge clinical decision-making. This study aims to use network meta-analysis (NMA) to synthesise existing evidence on non-pharmacological interventions for PH, offering updated clinical insights and evidence-based support to optimise treatment strategies. It will also provide recommendations for integrating these interventions into community-based chronic disease management.Methods and analysisTo identify potentially relevant randomised controlled trials, a reverse search strategy will be employed to ascertain all non-pharmacological interventions for PH. A well-constructed search strategy will be applied across nine academic databases (Web of Science, Embase, PubMed, PsycINFO, CENTRAL, AMED, CNKI, WF and VIP database) and three clinical trial registries (WHO ICTRP, ClinicalTrials.gov and ChiCTR) for studies conducted between 1 January 2014 and 1 August 2024. Two investigators will independently extract information from eligible articles and document reasons for exclusions. The primary outcomes will encompass changes in systolic and diastolic BP. Pairwise and Bayesian NMA will be conducted using ‘meta’ and ‘GeMTC’ package (R 4.4.1). Risk of bias will be assessed using the Risk of Bias 2 tool, and the quality of evidence will be evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation approach.Ethics and disseminationAs this review involves secondary analysis of previously published data, ethical approval is not required. The results will be published in peer-reviewed journals.PROSPERO registration numberCRD42023451073.