bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
Authors: Sandlow Sarah , Rai Puja , Shum Ann , Chen Hannah , Arnold Jeffrey , Jangi Sushrut 
Published: February 2023

ABSTRACT
Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this small molecule. We describe a unique case of biopsy-proven Kaposi sarcoma of the skin and colon in a patient with biologic-resistant ulcerative colitis after treatment with ozanimod for 2 months. Given the potential risk of malignancy associated with this agent, physicians should be aware of this rare adverse event.
Gastric Ectopic Pancreas With Pseudocyst Formation Causing Gastric Outlet Obstruction
Authors: Dickerson Austin , Farrell Aran , Bushra Abida , Celinski Scott , Konda Vani J.A. , Kale Hemangi , Nguyen Anh D. 
Published: February 2023

ABSTRACT
Ectopic pancreas is a rare entity referring to the presence of pancreatic tissue at an anatomic location distinct from the pancreas. Ectopic pancreatic lesions in the stomach present a diagnostic challenge because the lack of distinguishing imaging and endoscopic features make them difficult to differentiate from other types of submucosal lesions. We report a case of ectopic pancreas presenting as a gastric antral mass with a unique combination of rare complications: chronic pancreatitis and pseudocyst formation causing gastric outlet obstruction. This case highlights complications that can occur from ectopic pancreatic lesions and the challenges of diagnosing ectopic pancreas.
QPVA-Based Electrospun Anion Exchange Membrane for Fuel Cells
Authors: Samsudin Asep Muhamad , Hacker Viktor 
Published: February 2023

The anion exchange membrane is one of the core components that play a crucial and inseparable role in alkaline anion exchange membrane fuel cells. Anion exchange membranes (AEMs) were prepared from quaternary ammonium poly(vinyl alcohol) (QPVA) by an electrospinning method. QPVA was used both as material for electrospun fiber mats and as filler for the inter-fiber void matrix. The objective of this work is to investigate the influence of the inter-fibers void matrix filler concentration on the properties and performance of eQPVA-x AEMs. FTIR spectra were used to identify the chemical structures of the AEMs. The primary functional groups of PVA and quaternary ammonium-based ion conducting cation were detected. The surface morphology of QPVA nanofiber mats and eQPVA-x AEMs was observed using SEM. Electrospun nanofiber structures of QPVA with an average size of 100.96 nm were observed in SEM pictures. The ion exchange capacity, swelling properties, water uptake, and OH-ions conductivity were determined to evaluate the performance of eQPVA-x AEMs. By incorporating the QPVA matrix of 5 wt.% concentration, the eQPVA-5.0 AEMs attained the highest ion exchange capacity, water uptake, swelling properties, and OH− conductivity of 0.82 mmol g−1, 25.5%, 19.9%, and 2.26 m×s cm−1, respectively. Electrospun QPVA AEMs have the potential to accelerate the development of alkaline anion exchange membrane fuel cells.
Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
Authors: Huang Renyan , Shi Chenyan , Liu Guobin 
Published: February 2023

Abstract
Obesity is a main risk factor for diabetes and cardiovascular disorders and is closely linked to preadipocyte differentiation or adipogenesis. Peroxisome proliferator-activated receptor γ (PPARγ) is an indispensable transcription factor in adipogenesis. A newly identified long noncoding RNA, Acart, exerts a protective effect against cardiomyocyte injury by transactivating PPARγ signaling. However, the function of Acart in preadipocyte differentiation is unclear. To investigate the function of Acart in adipogenesis, a well-established preadipocyte, the 3T3-L1 cell line, was induced to differentiate, and Acart level was assessed during differentiation using quantitative real-time PCR. The biological role of Acart in adipogenesis was analyzed by assessing lipid droplet accumulation, PPARγ and CCAAT/enhancer-binding protein α (C/EBPα) expression, and 3T3-L1 cell proliferation and apoptosis after Acart silencing. We found that Acart level was promptly increased during preadipocyte differentiation in vitro. Acart was also significantly upregulated in obese mouse-derived subcutaneous, perirenal, and epididymal fat tissues compared with nonobese mouse-derived adipose tissues. Functionally, Acart depletion inhibited preadipocyte differentiation, as evidenced by a significant decrease in lipid accumulation and PPARγ and C/EBPα expression levels. Acart silencing also inhibited 3T3-L1 cell proliferation, whereas Acart overexpression accelerated 3T3-L1 cell proliferation and decreased cell apoptosis. Taken together, the current results reveal a novel function of Acart in regulating preadipocyte proliferation and differentiation.
Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report
Authors: Zhao Qiang , Li Zhi-Ke , Gui Yan , Ma Dai-Yuan , Du Guo-Bo , Li Xian-Fu 
Published: February 2023

Abstract
Primary malignant melanoma of the parotid gland (PGMM) is extremely rare, with a poor prognosis. Surgery is the main treatment option followed by adjuvant treatments such as radiotherapy, but which adjuvant treatment to be optimal is still controversial. In this case, a 63-year-old male PGMM patient was first misdiagnosed as a “myoepithelial tumor” and then treated with surgery, postoperative immunotherapy (sintilimab), chemotherapy, and radiotherapy successfully. The progression free survival was more than 19 months without signs of metastasis or recurrence to date. To our best knowledge, this is the first report of postoperative immunotherapy combined with chemotherapy and radiotherapy for PGMM. Our case indicated that combination therapy including surgery, adjuvant immunotherapy (sintilimab) combined with chemotherapy and radiotherapy may be a potential treatment option for PGMM, which needs further research.
Analysis of bacterial community structure of Fuzhuan tea with different processing techniques
Authors: Liu Shiquan , Li Taotao , Yu Songlin , Zhou Xiaohong , Liu Zhanjun , Zhang Xuemao , Cai Hongmei , Hu Zhiyuan 
Published: February 2023

Abstract
The composition and diversity of microbial communities are of considerable significance to the quality development of Camellia sinensis (Fuzhuan tea). In this study, we examined differences in the bacterial community structures of loose, lightly-pressed, hand-made, and machine-pressed Fuzhuan teas and raw dark tea. We observed notable differences in the bacterial communities of the five groups, where there were only 51 consensus sequences. ASV/OTU Venn diagram, Chao1, Ace, Simpson indices, and dilution curve analyses consistently revealed that machine-pressed tea exhibited the highest bacterial diversity. Taxonomically, Actinobacteria, Firmicutes, Proteobacteria, and Cyanobacteria were the dominant bacterial phyla in each group, whereas Corynebacterium, Methylobacterium, and Bifidobacterium were the dominant genera. Our findings revealed significant differences in the bacterial community structures of different Fuzhuan tea products derived from the same raw material, with bacterial diversity rising with increased product compaction.
Vacuum impregnation pre-treatment: A novel method for incorporating mono- and divalent cations into potato strips to reduce the acrylamide formation in French fries
Authors: Cirit Berkay , Canbay Hale Seçilmiş , Gürsoy Oğuz , Yilmaz Yusuf 
Published: February 2023

Abstract
The effect of different vacuum impregnation (VI) pre-treatments of potato strips [in water (control), NaCl, KCl or CaCl2 (0.1 M) for 10 and 15 min] on acrylamide formation in French fries after deep frying in sunflower oil at 175°C for 5 min was determined. The acrylamide content of fries prepared with potato strips pre-treated by VI in distilled water decreased from 0.82 to 0.24 µg/g when time increased to 15 min. Moreover, the acrylamide content of fries from 10 min-KCl pre-treatment (0.35 µg/g) decreased significantly to 0.04 µg/g when time was 15 min (p < 0.05). In comparison to control (10 min), the VI pre-treatment in KCl and NaCl for 15 min reduced the relative content of acrylamide by 95 and 91%, respectively, and VI in distilled water was able to decrease this value by 71%. Results indicated that monovalent cations (K and Na) were more effective in reducing acrylamide formation than divalent cation (Ca2+) when the VI pre-treatment time increased to 15 min. In conclusion, VI as a pre-treatment for mono- and divalent cations in fried potato production could be a useful technique in industrial applications to reduce acrylamide formation in fries in a short time.
Instructions on appropriate fasting prior to phlebotomy; effects on patient awareness, preparation, and biochemical parameters
Authors: Andrade Nélia S.V. , Curtin Sinead N. , Masih Ashiq , Fitzgibbon Brid , Herbert Katie , Gowen Mary , Lehane Margaret , Costelloe Seán J. 
Published: February 2023

Abstract

Objectives
This study investigated the effect of appropriate pre-phlebotomy instructions on patients’ awareness of the need to fast, their fasting status at phlebotomy, and the measurement of specific biochemical analytes and indices.

Methods
While booking their phlebotomy appointments, two-hundred outpatients, with a wide range of pre-existing medical conditions, were recruited and randomly assigned to either control or intervention groups. The control group received no instructions while the intervention group was verbally instructed to fast for precisely 12 h prior to their appointment. Serum samples were collected from participants to quantify common biochemical analytes and serum indices, some of which were known to be influenced by fasting status, such as triglyceride and the lipaemic index. At the same appointment, participants completed a survey assessing their perception of, and adherence to, fasting requirements.

Results
In the intervention group, 99% responded that they had fasted before phlebotomy vs. 16% of controls. Subjects stated they fasted for 12 h in 51% of the intervention group and 7% of the controls. Median concentrations for potassium and total bilirubin were statistically, but not clinically, significantly different. In the study, a single patient in the intervention group was found to have a lipaemic sample.

Conclusions
Without instruction, it appears few patients will fast appropriately prior to blood collection. This study suggests that most patients recall and adhere to verbal instructions regarding fasting. Though many in the control group stated they did not fast, triglyceride concentration and lipaemia were not significantly different from the intervention group, and biochemical analyses appear unaffected by fasting status.
“Am I really abroad?” The informal language contact and social networks of Chinese foundation students in the UK
Authors: Zhou Siyang , Rose Heath 
Published: February 2023

Abstract
British higher education institutions attract a large number of international students, especially Chinese students, to pursue degrees in the UK every year. This longitudinal mixed-methods study tracked the informal language contact and social networks of Chinese foundation program students in the UK for two terms. A Language Contact Questionnaire and a Study Abroad Social Network Survey were administered to 84 students and semi-structured interviews were conducted with 26 participants in the first term and the second term of study. Data revealed that the participants generally had a high percentage of L1 use, high academic L2 contact, and mainly L1 social networks during studying abroad, with little variation over the two terms. Their relationships with international friends were superficial and a vibrant international student community was not found. L2 topic multiplexity and online L2 contact frequency weakly predicted the total informal L2 contact at Term 1 and Term 2. This study underscores that degree-oriented SA participants may have different prioritization and leisure time routines compared with summer school participants or exchange students abroad. Thus, with an extra foundation year in the host country, the current sample seemed to prioritize academic preparation, rather than social integration.
Germany – Still a Welfare Partnership Country?
Authors: Zimmer Annette , Priller Eckhard 
Published: February 2023

Abstract
Germany’s traditional nonprofit sector, rooted in membership associations that served as intermediaries between citizens and government, is a story of the past. The organizations have either suffered from a significant decrease in membership, or they have turned into business-like organisations. As a result, welfare partnership is still in place. However, the partners have significantly changed: governments are enchanted with the logic of the market; nonprofit organizations are no longer part of civil society but proxies of corporate enterprises, and volunteering is welcomed by the government as a substitute for cheap labour.
E-waste in Vietnam: a narrative review of environmental contaminants and potential health risks
Authors: Poudel Kritika , Ketema Rahel Mesfin , Thi Thu Ngo Hien , Ikeda Atsuko , Minatoya Machiko 
Published: February 2023

Abstract
Informal electronic waste (e-waste) dismantling activities contribute to releasing hazardous compounds in the environment and potential exposure to humans and their health. These hazardous compounds include persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and heavy metals. This review searched papers addressing hazardous compounds emitted from e-waste recycling activities and their health effects in Vietnam. Based on the keywords searched in three electronic databases (PubMed, Psych Info, and Google scholar), we found 21 relevant studies in Vietnam. The review identifies extensive e-waste dismantling activities in Vietnam in the northern region. To measure the environmental exposure to hazardous compounds, samples such as e-waste recycling workshop dust, soil, air, and sediments were assessed, while human exposure levels were measured using participants’ hair, serum, or breast milk samples. Studies that compared levels of exposure in e-waste recycling sites and reference sites indicated higher levels of PBDEs, PCBs, and heavy metals were observed in both environmental and human samples from participants in e-waste recycling sites. Among environmental samples, hazardous chemicals were the most detected in dust from e-waste recycling sites. Considering both environmental and human samples, the highest exposure difference observed with PBDE ranged from 2-48-fold higher in e-waste processing sites than in the reference sites. PCBs showed nearly 3-fold higher levels in e-waste processing sites than in reference sites. In the e-waste processing sites, age-specific higher PCB levels were observed in older recycler’s serum samples. Among the heavy metals, Pb was highly detected in drinking water, indoor soil and human blood samples. While high detection of Ni in cooked rice, Mn in soil and diet, Zn in dust and As in urine were apparent. Exposure assessment from human biomonitoring showed participants, including children and mothers from the e-waste processing areas, had higher carcinogenic and non-carcinogenic risks than the reference sites. This review paper highlights the importance of further comprehensive studies on risk assessments of environmentally hazardous substances and their association with health outcomes at e-waste processing sites.
Targeting the gut–microbiota–brain axis in irritable bowel disease to improve cognitive function – recent knowledge and emerging therapeutic opportunities
Authors: Tang Heyong , Chen Xiaoqi , Huang Shun , Yin Gang , Wang Xiyang , Shen Guoming 
Published: February 2023

Abstract
The brain–gut axis forms a bidirectional communication system between the gastrointestinal (GI) tract and cognitive brain areas. Disturbances to this system in disease states such as inflammatory bowel disease have consequences for neuronal activity and subsequent cognitive function. The gut–microbiota–brain axis refers to the communication between gut-resident bacteria and the brain. This circuits exists to detect gut microorganisms and relay information to specific areas of the central nervous system (CNS) that in turn, regulate gut physiology. Changes in both the stability and diversity of the gut microbiota have been implicated in several neuronal disorders, including depression, autism spectrum disorder Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Correcting this imbalance with medicinal herbs, the metabolic products of dysregulated bacteria and probiotics have shown hope for the treatment of these neuronal disorders. In this review, we focus on recent advances in our understanding of the intricate connections between the gut–microbiota and the brain. We discuss the contribution of gut microbiota to neuronal disorders and the tangible links between diseases of the GI tract with cognitive function and behaviour. In this regard, we focus on irritable bowel syndrome (IBS) given its strong links to brain function and anxiety disorders. This adds to the growing body of evidence supporting targeted therapeutic strategies to modulate the gut microbiota for the treatment of brain/mental-health-related disease.
Wear properties of Al/TiO2 composites fabricated via combined compo-casting and APB process
Authors: Wang Daya , Heydari Vini Mohammad , Daneshmand Saeed , Demin Al-Khafaji Ali Hussein , Ramírez-Coronel Andrés Alexis , Alfilh Raed H. C. 
Published: February 2023

Abstract
Compo-casting method is one of the popular techniques to produce metal-based matrix composites. But one of the main challenges in this process is un-uniform spreading of reinforced subdivisions (particles) inside the metallic matrix and the lack of desirable mechanical properties of the final produced composites due to the low bonding strength among the metal matrix and reinforcement particles. To remove these difficulties and to promote the mechanical properties of these kind of composites, the accumulative press bonding (WAPB) technique as a supplementary technique to heighten the mechanical and microstructural evolution of the casted Al/TiO2 composite bars was utilized as a novelty in this study. The microstructure evolution and mechanical properties of these composites have been compared with various WAPB steps using tensile test, average Vickers micro hardness test, wear test and scanning electron microscopy (SEM). The SEM results revealed that during the higher APB steps, big titanium dioxide (TiO2) clusters are broken and the TiO2 particles are distributed uniformly. It was shown that cumulating the forming steps improved the mechanical properties of the composites. In general, combined compo-casting and APB process would consent making Al/TiO2 composites with high consistency and good microstructural and mechanical properties.
Kontaktlose induktive Strömungstomografie in grundlegender und angewandter Fluiddynamik
Authors: Sieger Max , Mitra Rahul , Glavinic Ivan , Ratajczak Matthias , Sonntag Stefanie , Gundrum Thomas , Stefani Frank , Wondrak Thomas , Eckert Sven 
Published: February 2023

Kurzfassung
Mit der kontaktlosen induktiven Strömungstomografie (CIFT) lassen sich Geschwindigkeitsfelder in elektrisch leitfähigen Flüssigkeiten global bestimmen. Kenntnisse über den Strömungszustand in Metallschmelzen sind für industrielle Prozesse, wie das Stranggießen von Stahl, von immenser Bedeutung und können auch in der Grundlagenforschung nutzbringend angewendet werden, z.B. zur Analyse von konvektiven Flüssigmetallströmungen als Modellsysteme des Wärmetransportes. Das Verfahren beruht auf der präzisen Messung kleinster Magnetfeldänderungen durch geeignete Sonden und der nachfolgenden Rekonstruktion der Strömungsstruktur durch die Lösung eines linearen inversen Problems. In dieser Veröffentlichung geben wir einen Überblick über die Entwicklungen der letzten Dekade und diskutierten je einen Anwendungsfall für CIFT aus der grundlegenden und der angewandten Fluiddynamik.
Neuronal SIRT3 Deletion Predisposes to Female-Specific Alterations in Cellular Metabolism, Memory, and Network Excitability
Authors: Pearson-Smith Jennifer N. , Fulton Ruth , Huynh Christopher Q. , Figueroa Anna G. , Huynh Gia B. , Liang Li-Ping , Gano Lindsey B. , Michel Cole R. , Reisdorph Nichole , Reisdorph Richard , Fritz Kristofer S. , Verdin Eric , Patel Manisha 
Published: February 2023

Mitochondrial dysfunction is an early event in the pathogenesis of neurologic disorders and aging. Sirtuin 3 (SIRT3) regulates mitochondrial function in response to the cellular environment through the reversible deacetylation of proteins involved in metabolism and reactive oxygen species detoxification. As the primary mitochondrial deacetylase, germline, or peripheral tissue-specific deletion of SIRT3 produces mitochondrial hyperacetylation and the accelerated development of age-related diseases. Given the unique metabolic demands of neurons, the role of SIRT3 in the brain is only beginning to emerge. Using mass spectrometry-based acetylomics, high-resolution respirometry, video-EEG, and cognition testing, we report targeted deletion of SIRT3 from select neurons in the cortex and hippocampus produces altered neuronal excitability and metabolic dysfunction in female mice. Targeted deletion of SIRT3 from neuronal helix-loop-helix 1 (NEX)-expressing neurons resulted in mitochondrial hyperacetylation, female-specific superoxide dismutase-2 (SOD2) modification, increased steady-state superoxide levels, metabolic reprogramming, altered neuronal excitability, and working spatial memory deficits. Inducible neuronal deletion of SIRT3 likewise produced female-specific deficits in spatial working memory. Together, the data demonstrate that deletion of SIRT3 from forebrain neurons selectively predisposes female mice to deficits in mitochondrial and cognitive function.SIGNIFICANCE STATEMENTMitochondrial SIRT3 is an enzyme shown to regulate energy metabolism and antioxidant function, by direct deacetylation of proteins. In this study, we show that neuronal SIRT3 deficiency renders female mice selectively vulnerable to impairment in redox and metabolic function, spatial memory, and neuronal excitability. The observed sex-specific effects on cognition and neuronal excitability in female SIRT3-deficient mice suggest that mitochondrial dysfunction may be one factor underlying comorbid neuronal diseases, such as Alzheimer's disease and epilepsy. Furthermore, the data suggest that SIRT3 dysfunction may predispose females to age-related metabolic and cognitive impairment.