bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers and the post-thrombotic syndrome: A systematic review of biomarkers associated with the occurrence of the post-thrombotic syndrome after lower extremity deep venous thrombosis
Authors: Harbsmeier Aksel Nathan , Altintas Izzet , Iversen Kasper , Andersen Ove , Nehlin Jan O. 
Published: August 2023

Introduction Post-thrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis (DVT). Biomarkers are potentially valuable clinical tools for handling PTS. The purpose of this review was to examine which biomarkers are associated with the development of PTS in adults with lower extremity DVT. Methods We performed a systematic review of all English language prospective studies of biomarkers and PTS published in PubMed and EMBASE. Studies were included if diagnosing DVT by diagnostic imaging and assessing PTS by clinical scales, for example, the Villalta scale. Biomarkers of thrombophilia and pathological clot properties were not assessed. Data was reported qualitatively. Results 15 prospective studies were included. Studies varied widely in study design and methods of data analysis. Forty-six different biomarkers were examined, with seven being measured in two or more studies. The most frequently studied biomarkers were D-dimer, CRP, and IL-6. Associations between PTS and D-dimer were predominantly significant, while results on CRP and IL-6 were inconsistent. ICAM-1 was consistently associated with PTS in all studies and at all timepoints. IL-10 was significantly related to PTS development in the largest study and at all time points. Adiponectin, tPA, HRG and TAFI, MMP-1 and -8, and TIMP-1 and -2 were significantly associated with PTS in single studies. Conclusion (1) Further research on biomarkers and PTS is clearly warranted. (2) Significant differences in study designs made it difficult to draw reliable conclusions regarding individual biomarkers. We suggest the implementation of a standardized framework for the study of biomarkers and PTS, to make comparison of future studies more feasible. (3) D-dimer, ICAM-1, IL-10, MMP-1 and 8, TIMP-1, TIMP-2, and adiponectin are clinical biomarkers of particular interest to include in future studies of PTS. Large scale systemic quantitative proteomic analyses of DVT patients could help identify novel biomarkers of interest in PTS-patients.
Continuous Electroencephalography (EEG) Protocol Improves Seizure Detection in Children on Extracorporeal Membrane Oxygenation
Authors: deCampo Danielle , Husari Khalil S. , Bembea Melania M. , Habela Christa W. , Ritzl Eva K. 
Published: August 2023

Background / Objective Seizures are a complication for pediatric patients requiring extracorporeal membrane oxygenation (ECMO). There are no standardized guidelines regarding continuous electroencephalography (EEG) monitoring to detect seizures in these patients, and the impact of protocolized monitoring has not been evaluated. Here we examined the effects of continuous EEG protocol implementation in our pediatric ECMO population. Methods Retrospective chart reviews were conducted on 57 patients who underwent extracorporeal membrane oxygenation and concurrent continuous EEG out of 165 patients supported on extracorporeal membrane oxygenation. Timing of continuous EEG initiation and seizures detected by continuous EEG was determined for 5 years prior to and 15 months after protocol implementation. Results Protocol implementation was associated with increased ECMO–supported patients who were concurrently monitored by continuous EEG. Time from ECMO cannulation to continuous EEG initiation was shorter (median 7 hours after versus 16.2 hours before; P < .001). Patients who had ongoing seizures at the start of continuous EEG recording decreased from 64% preprotocol to 0% postprotocol ( P < .001), and there was an associated earlier time to break in status epilepticus postprotocol. Seizures were detected past 48 hours after cannulation in 50% of patients in the postprotocol group. Conclusions Protocol implementation resulted in earlier continuous EEG initiation and more EEGs initiated before seizure onset with evidence of altered seizure dynamics. Although current recommendations suggest that continuous EEG duration of 24-48 hours results in seizure detection for >90% of critically ill adults, longer monitoring may be needed to reliably detect seizures in children supported with ECMO, particularly if monitoring is initiated earlier in the post-cannulation period.
Women’s Attitudes Toward Intimate Partner Violence in Low- and Middle-Income Countries of Southern Asia
Authors: Pettitt Lauren Alexandra , Biswas Raaj Kishore , Bhowmik Jahar 
Published: August 2023

Purpose The present study identified the vulnerable IPV cohorts of South Asian women, and the prevalence of and predictors of the women’s IPV acceptance. Design Cross-sectional survey - the United Nations Children’s Fund multiple index cluster survey. Setting Many South Asian women are accepting of IPV. Studies mostly focus on individual countries. Subject 103 139 ever-married women from Bangladesh, Laos and Nepal. Measures Women’s attitudes toward IPV were measured using a set of five, fixed, binary responses. Analysis Following bivariate analysis, complex survey weight adjusted logistic regression models were fitted for individual country data, and the pooled sample. Results Of the sampled South Asian women 27.8% accepted IPV, and no major variation among countries in IPV acceptance. Education was the most reliable protector against IPV acceptance whereby, higher educational attainment systematically reduced IPV acceptance (OR = .61 [.56-.83]). Other significant protective factors were being un-married (Married OR = 1.34 [1.28-1.42]), having increased wealth (OR = .71 [.56-.83]), and being over 24 years old (OR = .88 [.83-.97]). Conclusion Only education produced absolute consistency at the country and region level; there seems to be no blanket solution for regionally reducing women’s IPV acceptance rates in Southern Asia. Focus on the least educated women and making education more accessible should be prioritised. Future IPV studies can consider measurement methods for women’s direct exposure to patriarchal standards and within community interaction.
Facilitating United States Service Members’ Transition Out of the Military: A Self-Determination Theory Perspective
Authors: Raabe Johannes , Eckenrod Morgan R. , Cooper Emily , Crain Jared A. 
Published: August 2023

The purpose of the current qualitative research was to explore the role of veterans’ basic psychological needs during the military transition. Using purposive and snowball sampling, 16 veterans ( n = 13 male, n = 3 female; Mage = 38.3, SDage = 5.8 years) of the United States military ( n = 8 Army, n = 4 Marine Corps, n = 3 Navy) were recruited to participate in semi-structured interviews. Reflexive thematic analysis of the qualitative data revealed seven themes: (a) veterans experienced different levels of relatedness in the military community during their transition, (b) perceptions of choice and control had varying influences on veterans’ sense of autonomy during their transition, (c) veterans experienced a false sense of competence starting the transition, (d) figuring out how to transfer military experiences and skills to civilian jobs posed a meaningful challenge for veterans’ sense of competence throughout the application process, (e) multiple factors helped veterans regain their sense of competence during the job search, (f) veterans experienced difficulties adjusting to new civilian job environment, and (g) family played a major role in fostering veterans’ sense of autonomy during the transition. These findings offer multiple conceptual and practical implications, including the context-specificity of perceived competence and relatedness, challenge of skill transfer, and temporality of backup plans, that can be used to help service members’ transition more effectively.
NeoTalk: Communication Skills Training for Neonatal Clinicians
Authors: Guttmann Katherine F. , Meshkati Malorie , Frydman Julia , Smith Cardinale B. , Dow Lindsay , Weintraub Andrea S. 
Published: August 2023

Background Despite proven benefit, pediatric subspecialists often have not been offered formal serious illness communication skills training. We sought to: 1) develop and evaluate the impact of a communication skills course, based on the VitalTalk framework, on Neonatal Intensive Care Unit (NICU) clinicians; 2) evaluate provider comfort with key serious illness communication skills and frequency of use of those skills, before and after “NeoTalk” and; 3) explore differences and similarities between adult and pediatric serious illness communication skills courses. Methods We developed a NICU specific communication skills course and surveyed course participants to evaluate comfort with key communication skills before and after course participation, and frequency of use of key skills before and 2 months after our course. Wilcoxon signed rank tests and Kruskal-Wallis tests were performed to compare participant responses across time points. Results 34 providers completed NeoTalk training. Complete pre- and post-course data was available for 29 participants. Participants reported increased comfort with skills including ‘sharing difficult news’ ( P = .018), and ‘responding to emotion’ ( P = .002). Participants did not report increased frequency in using target skills 2 months after training. Conclusions A multi-disciplinary cohort of NICU providers endorsed increased confidence in key communication skills but not increased skill application 2-months post-course completion. While a single course can successfully teach skills, additional exposure may be necessary to build new communication habits. Our experience developing NeoTalk helped elucidate some of the ways in which conversations about seriously ill infants may be different from conversations about seriously ill adults.
Pseudocystic inflammatory demyelinating lesions in multiple sclerosis: A clinical, radiological, and pathological description
Authors: Cluse Florent , Fenouil Tanguy , Vukusic Sandra , Ducray François , Cotton François , Marignier Romain , Durand-Dubief Françoise 
Published: August 2023

Background: Pseudocystic inflammatory demyelinating lesions (PIDLs) are poorly described in MS and might represent a diagnostic challenge. Objectives: We described the clinical, radiological, pathological, and follow-up characteristics of 13 PIDL in 9 MS patients. Methods: We constituted a single-center retrospective case series of PIDLs in MS, defined on MRI as expansive cyst-like lesions, with a fluid-signal content, and a diameter of 1 cm or more. Results: PIDL often occurred at first event (56%), were often asymptomatic (69%), and encircled by a hypo-T2 diffusion-restricted rim and a thin ring-like gadolinium enhancement (100%) on magnetic resonance imaging (MRI). Associated typical MS lesions were constant. Biopsies from two PIDLs displayed classical features of active MS, except for unusual edema. Conclusion: PIDLs are clinically unremarkable and associated with a good outcome. Their easily recognizable MRI features could help avoid biopsy.
Understanding the lived experience of chronic pain: A systematic review and synthesis of qualitative evidence syntheses
Authors: van Rysewyk Simon , Blomkvist Renée , Chuter Antony , Crighton Rhea , Hodson Fiona , Roomes David , Smith Blair H , Toye Francine 
Published: August 2023

Background Although multiple measures of the causes and consequences of chronic non-cancer pain (CNCP) are available and can inform pain management, no quantitative summary of these measures can describe the meaning of pain for a patient. The lived experience of pain tends to be a blind spot in pain management. This study aimed to: (1) integrate qualitative research investigating the lived experience of a range of CNCP conditions; (2) establish common qualitative themes in CNCP experience; and (3) evaluate the relevance of our results through a survey questionnaire based on these themes, administered across the United Kingdom. Methods Four bibliographic databases were searched from inception to February 2021 to identify Qualitative Evidence Syntheses (QES) that investigated the lived experience of CNCP and its impact on everyday life and activities. Themes and trends were derived by thematic qualitative analysis in collaboration with two patient and public involvement representatives who co-created twenty survey statements. The survey was developed for testing the QES themes for validity in people living with pain. Results The research team identified and screened 1323 titles, and considered 86 abstracts, including 20 in the final review. Eight themes were developed from the study findings: (1) my pain gives rise to negative emotions; (2) changes to my life and to myself; (3) adapting to my new normal; (4) effects of my pain management strategies; (5) hiding and showing my pain; (6) medically explaining my pain; (7) relationships to those around me; and (8) working while in pain. Each theme gave rise to one or two survey questions. The survey was shared with members of the UK pain community over a 2-week period in November 2021, and was completed by 1219 people, largely confirming the above themes. Conclusion/Implications This study provides a validated summary of the lived experience of CNCP. It highlights the adverse nature, complications, and consequences of living with CNCP in the UK and the multiple shortcomings in the ways in which pain is addressed by others in the UK. Our findings are consistent with published meta-ethnographies on chronic non-malignant musculoskeletal pain and chronic low-back pain. Despite the underrepresentation of qualitative research in the pain literature compared to quantitative approaches, for understanding the complexity of the lived experience of pain, qualitative research is an essential tool.
Hygienic practice during complementary feeding and its associated factors among mothers/caregivers of children aged 6–24 months in Wolaita Sodo town, southern Ethiopia
Authors: Kassie Gizachew Ambaw , Gebeyehu Natnael Atnafu , Gesese Molalegn Mesele , Chekol Abebe Endeshaw , Mengstie Misganaw Asmamaw , Seid Mohammed Abdu , Alebachew Bayih Wubet , Feleke Sefineh Fenta , Amare Tesfa Natnael , Dejenie Tadesse Asmamaw , Bantie Berihun , Solomon Kebede Yenealem , Zemene Melkamu Aderajew , Mengist Dessie Anteneh , Anley Denekew Tenaw , Asmare Adella Getachew 
Published: August 2023

Introduction: Complementary feeding is an important stage in a child’s development as it provides the necessary nutrients for optimal growth and development. However, improper handling, storage, and preparation of complementary foods can result in contamination by microorganisms, leading to foodborne illnesses and malnutrition. Therefore, this study aimed to determine hygienic practices during complementary feeding and associated factors among mothers of children aged 6–24 months in Wolaita Sodo town, southern Ethiopia. Methods: A community-based, cross-sectional study was undertaken among mothers/caregivers of children aged 6–24 months from December 1–30, 2022. A total of 602 participants were recruited using a simple random sampling procedure. The hygienic practice of complementary feeding was assessed based on a related seven items questionnaire (Cronbach’s alpha 0.72). Data were entered into Epi-data version 4.6 and analyzed using Statistical Package for Social Science version 26. Multivariable binary logistic regression was used to identify the statistically significant factors associated with proper hygienic practice of complementary feeding. Variables with a p-value of <0.05 in the multivariable logistic regression analysis model were considered statistically significant. Results: The study indicated that 42.0%, (95% confidence interval (CI): 38, 45.8) of the mothers/caregivers of children aged 6–24 months had proper hygienic practices during complementary feeding. Mothers who could read and write (adjusted odd ratio (AOR): 3.36, 95% CI (1.53, 7.41)) and those who had completed primary school (AOR: 1.7, 95% CI (1.02, 2.85)), media exposure (AOR: 3.38, 95% CI (2.1, 5.4)), and attitude toward hygienic practice (AOR: 3.29, 95% CI (2.2, 4.91)) were independent predictors of hygiene practices during complementary feeding. Conclusion: This study found that the prevalence of hygiene practices during complementary feeding was relatively low. Being educated, access to media, and positive attitudes toward hygienic practices were predicting factors. As a result, strengthening training and counseling services for mothers regarding complementary feeding and processing is recommended.
India’s Economic Integration with Japan: A Services Trade Perspective
Authors: Gupta Pralok 
Published: August 2023

India and Japan have strong economic linkages, which were improved over the years, particularly after signing the Comprehensive Economic Partnership Agreement (CEPA) in 2011. Not only trade, but investment has also increased between India and Japan over the years and Japan has become the fifth largest investor for India in 2021. Against this backdrop, this article aims to analyse India’s economic integration with Japan from a services trade perspective. The article finds that increased services trade between India and Japan has contributed to enhancing the economic integration between these two countries, as envisaged by their political leaders through their regular engagements over the years. JEL Classification: F14, F15
Osteochondral Allograft and Concurrent Meniscal Allograft Transplantation
Authors: Ihn Hansel E. , Nestorovski Douglas , Cho Austin , Hatch George F. 
Published: August 2023

Background: Symptomatic, full-thickness chondral defects often are associated with meniscal deficiencies. These are difficult problems to manage in the young, high-demand patient population. A number of differing techniques have been published with no consensus. While more recent techniques have favored minimally invasive approaches, an open approach with tubercle osteotomy to maximize visualization of all knee compartments can still provide favorable outcomes when using a careful technique and postoperative protocol. Indications: Young, high-demand patients with long-standing meniscal deficiency and resultant chondral defects are indicated for cartilage restoration and preservation procedures. A meniscal allograft transplantation is indicated in symptomatic patients with prior total or subtotal meniscectomy. It is important to address other concomitant pathology such as instability, alignment, and chondral defects. Concomitant procedures are often performed with meniscal transplants, including osteochondral allograft transplantation for larger defects. Technique Description: This surgical technique video demonstrates a tibial tubercle osteotomy approach to gain access to both the medial and lateral tibiofemoral compartments. An arthroscopic-assisted bone slot technique was performed for meniscal allograft transplantation. Appropriately sized osteochondral allograft bone plugs were then transplanted onto the medial and femoral condyles with a press fit technique. Results: At 1-year follow-up, the presented patient has regained full motion and are back to full activities. Discussion/Conclusion: Full-thickness chondral defects associated with meniscal deficiency in a young, high-demand patient is a difficult problem to manage. Recent results using minimally invasive approaches have demonstrated favorable mid- and long-term outcomes. In patients with pathology that may preclude a minimally invasive approach, an open technique with osteotomy can still have a promising outcome. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Adsorption of gold nanoparticles on illite under high solid/liquid ratio and initial pH conditions
Authors: Zeng Ping , Nie Xin , Qin Zonghua , Luo Suxing , Fu Yuhong , Yu Wenbin , Yang Meizhi , Luo Wenqi , Yang Hai , Wan Quan 
Published: August 2023

AbstractAdsorption of nanoparticles on minerals affects the fate and transport of nanoparticles directly and is of great significance to many fields, including research into ore deposits, geochemistry, the environment and mineral materials. Whereas many previous studies have been conducted under the equilibrium pH and low solid (mineral) to liquid (nanoparticle suspension) ratio conditions, adsorption processes under initial pH and high solid/liquid ratio conditions may represent many important yet underexamined complex scenarios. To fill in this research gap, the adsorption of gold nanoparticles on illite was investigated experimentally at a relatively high solid/liquid ratio of 5 g L–1 and the effects of initial pH, ionic strength, citrate concentration, temperature and illite particle size were evaluated. The adsorbed amount of gold nanoparticles (from <5% to nearly 100%) increased with increasing ionic strength, temperature and citrate concentration and decreased with increasing pH and illite particle size. The presence of illite resulted in the dynamic evolution of the pH of the suspension, which, along with solution chemistry parameters, controlled the electrostatic interaction of illite and gold nanoparticles. The adsorption results, scanning electron microscopy observations and surface properties of illite suggest that the negatively charged gold nanoparticles were adsorbed predominantly on the positive illite edges through electrostatic interaction. The electrostatic attraction between illite and gold nanoparticles appeared to be strong, supported by the minor amount of desorption. These research findings are expected to provide a valuable reference regarding many critical issues in the geosciences as well as for industrial applications.