bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allergy to Argan Oil Confirmed by Oral Challenge Test in Children: Case Report
Authors: Aminou Sara , Mahraoui Chafiq 
Published: April 2023

Aims: The prevalence of allergy to Argan oil is increasing over the years. It manifests itself in an extremely polymorphous way and responds to all possible routes of exposure: ingestion, contact or inhalation. The provocation test remains the key examination to confirm an allergy to Argan oil.
Presentation of Case: We report the observation of a six-year-old girl presenting with immediate urticaria after ingestion of argan oil.
Discussion: The allergological investigation points to sensitisation of the skin only, with positive prick tests. An oral provocation test was performed and published for the first time to confirm the diagnosis of allergy to argan oil in our patient.
Conclusion: Argan is widely used for its benefits in the cosmetic industry and as a food ingredient. Further studies are needed to explore the mechanisms of sensitisation to Argan oil.
Bacteriological Assessment of Smoked-Dried White Shrimp (Nematopalaemon hastatus Aurivillius, 1898) Sold in Calabar, Nigeria
Authors: Ebob Tarh, Jacqueline , Emmanuel Effiong Bassey, , Maurice Mbah, , Solomon Ekpiken, Ekpiken , Akpak Upula, Sylvanus 
Published: April 2023

Aim: Enumeration of bacterial counts is an important index of assessing the safety and quality of food products. This study aimed to investigate the occurrence of pathogenic bacteria in white shrimp samples obtained from major markets serving consumers in Calabar.
Study Design: This study was a cross sectional study conducted between April 2017 and April 2018.
Methodology: One hundred and twenty (120) samples of smoked dried Nematopalaemon hastatus (white shrimp) were analyzed for the presence of bacterial pathogens. Bacterial loads and identification of isolated organisms was determined using standard microbiological methods.
Results: The results showed that 66.7% of the analyzed shrimps had aerobic bacterial counts exceeding the upper permissible limit (<1.0x106Cfu/g) and 56.7% had unsatisfactory (˃20Cfu/g) Vibrio counts. The study revealed the presence of different bacteria genera namely Klebsiella, Salmonella, Pseudomonas, Serratia, Vibrio, Citrobacter, Proteus, Aeromonas, Streptococcus, Escherichia, Coagulase-negative Staphylococci (CoNS), Enterobacter and Bacillus. Predominant organism was Salmonella spp (26.7%), followed by Vibrio spp (21.7%) while the least isolated organisms were Bacillus spp and Coagulase-Negative Staphylococci (1.7%) each. The occurrence of high counts of pathogens in seafood may cause food poisoning; especially in individuals who consume this seafood raw, or lightly or insufficiently cooked.
Conclusion: Hence, seafood should be processed and packaged under standard hygienic conditions to reduce the risk of microbial contamination. In addition, public health awareness campaign targeted at consumers and vendors should be optimized with frequent monitoring by regulatory agencies.
Transition Decision of Hybrid Entrepreneurship in the Post-pandemic Period: Understanding the New Normal Factors in Developing Context
Authors: Sachitra Vilani , Jaward Fathima Sajda 
Published: April 2023

Purpose: The uncertainties surrounding the COVID-19 pandemic have inspired new business ventures. The best approach to overcome the obstacles in pandemic is hybrid entrepreneurship, which is defined as "holding the current job while creating a new business”. The study aims to discover the new normal characteristics that influence the engagement in hybrid entrepreneurship in Sri Lanka.
Methods: Schlossberg’s transition theory was adopted as the theoretical framework. Four transition elements; Situation, Self, Support, and Strategies used as the new normal factors. Snowball sampling method was used to select the participants who have both full-time employment and their own businesses during post-pandemic period. Data were gathered from 119 individuals using a standardized questionnaire. Hypotheses were tested using multiple regression analysis.
Findings: The majority of the respondents have their own small enterprises. The element ‘strategies’ is the most significant influencing factor on participation in hybrid entrepreneurship, followed by ‘self’. Support and situation elements have the least impact on hybrid entrepreneurship.
Research Implication: The policy implications of better understanding this transition could result in support systems aimed at better fostering hybrid entrepreneurship, given that ventures established by hybrid entrepreneurs are typically robust with strong chances of survival. Establishing support structures for hybrid entrepreneurs to assist with the growth of their ventures could be greatly beneficial for both employment and economic growth.
Originality: Grounded in Schlossberg’s transition theory, the study offers insight into the specific factors that could influence the transition decision of hybrid entrepreneurship.
Measurements of fetal dose with Mevion S250i proton therapy system with HYPERSCAN
Authors: Hopfensperger Karolyn M. , Li Xing , Paxton Adam , Sarkar Vikren , Su Fan‐Chi Frances , Price Ryan G. , Salter Bill , St. James Sara 
Published: April 2023

AbstractPurposeTo characterize potential dose to the fetus for all modes of delivery (dynamic adaptive aperture, static adaptive aperture, and no adaptive aperture) for the Mevion S250i Proton Therapy System with HYPERSCAN and compare the findings with those of other available proton systems.Materials and MethodsFetal dose measurements were performed for all three modes of dose delivery on the Mevion S250i Proton therapy system with HYPERSCAN (static aperture, dynamic aperture and uncollimated). Standard treatment plans were created in RayStation for a left‐sided brain lesion treated with a vertex field, a left lateral field, and a posterior field. Measurements were performed using WENDI and the RANDO with the detector placed at representative locations to mimic the growth and movement of the fetus at different gestational stages.ResultsThe fetal dose measurements varied with fetus position and the largest measured dose was 64.7 μSv per 2 Gy (RBE) fraction using the dynamic aperture. The smallest estimated fetal dose was 45.0 μSv per 2 Gy (RBE) at the base of the RANDO abdomen (47 cm from isocenter to the outer width of WENDI and 58.5 cm from the center of the WENDI detector) for the static aperture delivery. The vertex fields at all depths had larger contributions to the total dose than the other two and the dynamic aperture plans resulted in the highest dose measured for all depths.ConclusionThe reported doses are lower than reported doses using a double‐scattering system. This work suggests that avoiding vertex fields and using the static aperture will help minimize dose to the fetus.
Reliability Improvement and Effective Switching Layer Model of Thin‐Film MoS2 Memristors
Authors: Huang Yifu , Gu Yuqian , Mohan Sivasakthya , Dolocan Andrei , Ignacio Nicholas D. , Kutagulla Shanmukh , Matthews Kevin , Londoño‐Calderon Alejandra , Chang Yao‐Feng , Chen Ying‐Chen , Warner Jamie H. , Pettes Michael T. , Lee Jack C. , Akinwande Deji 
Published: April 2023

Abstract2D memristors have demonstrated attractive resistive switching characteristics recently but also suffer from the reliability issue, which limits practical applications. Previous efforts on 2D memristors have primarily focused on exploring new material systems, while damage from the metallization step remains a practical concern for the reliability of 2D memristors. Here, the impact of metallization conditions and the thickness of MoS2 films on the reliability and other device metrics of MoS2‐based memristors is carefully studied. The statistical electrical measurements show that the reliability can be improved to 92% for yield and improved by ≈16× for average DC cycling endurance in the devices by reducing the top electrode (TE) deposition rate and increasing the thickness of MoS2 films. Intriguing convergence of switching voltages and resistance ratio is revealed by the statistical analysis of experimental switching cycles. An “effective switching layer” model compatible with both monolayer and few‐layer MoS2, is proposed to understand the reliability improvement related to the optimization of fabrication configuration and the convergence of switching metrics. The Monte Carlo simulations help illustrate the underlying physics of endurance failure associated with cluster formation and provide additional insight into endurance improvement with device fabrication optimization.
Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing
Authors: Jung Su Hyun , Jang Bong Hwan , Kwon Seyong , Park Sung Jin , Park Tae‐Eun , Kang Joo H. 
Published: April 2023

AbstractAutologous implantable scaffolds that induce vasculogenesis have shown great potential in tissue regeneration; however, previous attempts mainly relied on cell‐laden hydrogel patches using fat tissues or platelet‐rich plasma, which are insufficient for generating a uniform vasculature in a scalable manner. Here, implantable vascularized engineered thrombi (IVETs) are presented using autologous whole blood, which potentiate effective skin wound healing by constructing robust microcapillary vessel networks at the wound site. Microfluidic shear stresses enable the alignment of bundled fibrin fibers along the direction of the blood flow streamlines and the activation of platelets, both of which offer moderate stiffness of the microenvironment optimal for facilitating endothelial cell maturation and vascularization. Rodent dorsal skin wounds patched with IVET present superior wound closure rates (96.08 ± 1.58%), epidermis thickness, collagen deposition, hair follicle numbers, and neutrophil infiltration, which are permitted by enhanced microvascular circulation. Moreover, IVET treatment accelerates wound healing by recruiting M2 phenotype macrophages.
Distinct Contact Guidance Mechanisms in Single Endothelial Cells and in Monolayers
Authors: Leclech Claire , Krishnamurthy Apoorvaa , Muller Laurent , Barakat Abdul I. 
Published: April 2023

AbstractIn many tissues, cell shape and orientation are controlled by a combination of internal and external biophysical cues. Anisotropic substrate topography is a ubiquitous cue that leads to cellular elongation and alignment, a process termed contact guidance whose underlying mechanisms remain incompletely understood. Additionally, whether contact guidance responses are similar in single cells and in cellular monolayers is unknown. Here, these questions in vascular endothelial cells (ECs) that in vivo form a monolayer that lines blood vessels are addressed. Culturing single ECs on microgrooved substrates that constitute an idealized mimic of anisotropic basement membrane (BM) topography elicits a strong, groove depth‐dependent contact guidance response. This response is principally driven by persistence bias of cell protrusions in the direction of the grooves and is surprisingly insensitive to actin stress fiber disruption. Interestingly, the contact guidance response is greatly attenuated in confluent monolayers, and cell shape and alignment in that case are driven by the organization of the BM secreted by the cells, which leads to a loss of cellular interaction with the microgrooves. The present finding of distinct contact guidance mechanisms in single ECs and in EC monolayers promises to inform strategies aimed at designing topographically patterned endovascular devices.
Chemo‐ and Diastereoselective Synthesis of Polyheterocycles by Rhodium(III)‐Catalyzed sp2/sp3 C−H Activation of 2‐Arylquinazolin‐4(3H)‐ones with 3‐Methylmaleimides
Authors: Devkota Shreedhar , Akhtar Muhammad Saeed , Lee Yong Rok 
Published: April 2023

AbstractRhodium(III)‐catalyzed sp2/sp3 C−H activation/annulation of 2‐arylquinazolin‐4(3H)‐ones with 3‐methylmaleimides is explored. This protocol provides diversely functionalized isoindoloquinazolinones in good yields upon reaction with various maleimides. This Rh(III)‐catalyzed protocol can be applied for the chemo‐ and diastereoselective synthesis of various polyheterocycles.magnified image
Biocatalytic Transamination of Aldolase‐Derived 3‐Hydroxy Ketones
Authors: Pickl Mathias , Ebner Markus , Gittings Samantha , Clapés Pere , Kroutil Wolfgang 
Published: April 2023

AbstractAlthough optical pure amino alcohols are in high demand due to their widespread applicability, they still remain challenging to synthesize, since commonly elaborated protection strategies are required. Here, a multi‐enzymatic methodology is presented that circumvents this obstacle furnishing enantioenriched 1,3‐amino alcohols out of commodity chemicals. A Type I aldolase forged the carbon backbone with an enantioenriched aldol motif, which was subsequently subjected to enzymatic transamination. A panel of 194 TAs was tested on diverse nine aldol products prepared through different nucleophiles and electrophiles. Due to the availability of (R)‐ and (S)‐selective TAs, both diastereomers of the 1,3‐amino alcohol motif were accessible. A two‐step process enabled the synthesis of the desired amino alcohols with up to three chiral centers with de up to >97 in the final products.magnified image
Associations of minor histocompatibility antigens with outcomes following allogeneic hematopoietic cell transplantation
Authors: Jadi Othmane , Tang Hancong , Olsen Kelly , Vensko Steven , Zhu Qianqian , Wang Yiwen , Haiman Christopher A. , Pooler Loreall , Sheng Xin , Brock Guy , Webb Amy , Pasquini Marcelo C. , McCarthy Philip L. , Spellman Stephen R. , Hahn Theresa , Vincent Benjamin , Armistead Paul , Sucheston‐Campbell Lara E. 
Published: April 2023

AbstractThe role of minor histocompatibility antigens (mHAs) in mediating graft versus leukemia and graft versus host disease (GvHD) following allogeneic hematopoietic cell transplantation (alloHCT) is recognized but not well‐characterized. By implementing improved methods for mHA prediction in two large patient cohorts, this study aimed to comprehensively explore the role of mHAs in alloHCT by analyzing whether (1) the number of predicted mHAs, or (2) individual mHAs are associated with clinical outcomes. The study population consisted of 2249 donor–recipient pairs treated for acute myeloid leukemia and myelodysplastic syndrome with alloHCT. A Cox proportional hazard model showed that patients with a class I mHA count greater than the population median had an increased hazard of GvHD mortality (hazard ratio [HR] = 1.39, 95% confidence interval [CI] = 1.01, 1.77, p = .046). Competing risk analyses identified the class I mHAs DLRCKYISL (GSTP), WEHGPTSLL (CRISPLD2), and STSPTTNVL (SERPINF2) were associated with increased GVHD mortality (HR = 2.84, 95% CI = 1.52, 5.31, p = .01), decreased leukemia‐free survival (LFS) (HR = 1.94, 95% CI = 1.27, 2.95, p = .044), and increased disease‐related mortality (DRM) (HR = 2.32, 95% CI = 1.5, 3.6, p = .008), respectively. One class II mHA YQEIAAIPSAGRERQ (TACC2) was associated with increased risk of treatment‐related mortality (TRM) (HR = 3.05, 95% CI = 1.75, 5.31, p = .02). WEHGPTSLL and STSPTTNVL were both present within HLA haplotype B*40:01‐C*03:04 and showed a positive dose–response relationship with increased all‐cause mortality and DRM and decreased LFS, indicating these two mHAs contribute to the risk of mortality in an additive manner. Our study reports the first large‐scale investigation of the associations of predicted mHA peptides with clinical outcomes following alloHCT.
Novel NALCN variant linked to temporal lobe epilepsy
Authors: Nguyen Emmanuelle , Tétreault Martine , Toffa Dènahin Hinnoutondji , Cossette Patrick , Samarut Éric , Nguyen Dang Khoa 
Published: April 2023

AbstractThe sodium leak channel (NALCN) gene encodes a sodium leak channel that plays an important role in the regulation of the resting membrane potential and the control of neuronal excitability. Mutations in the NALCN gene have been reported in patients with infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD syndrome). We describe the case of a father with drug‐resistant left temporo‐orbitofrontal epilepsy and his son with mildly‐symptomatic temporal epilepsy (only recurrent déjà vu auras) whose genetic panels identified a likely pathogenic deletion of exon 27 on the NALCN gene. Our study helps broaden the clinical spectrum of diseases associated with mutations in the NALCN gene.
Zinc‐Mediated Diastereoselective Annulation of Cyclopropanols with Alkylidenemalononitriles via Enolized Homoenolate
Authors: Tsukiji Kento , Hayakawa Takeru , Kanemoto Kazuya , Yoshikai Naohiko 
Published: April 2023

AbstractA zinc‐mediated annulation reaction between cyclopropanols and alkylidenemalononitriles is reported. The reaction is promoted in the presence of Et2Zn and 1,4‐diazabicyclo[2.2.2]octane (DABCO) in DMSO at 80 °C, affording cyclopropane‐fused 6‐amino‐3,4‐dihydro‐2H‐pyran‐5‐carbonitrile derivatives in moderate to good yields with high diastereoselectivity. The reaction is proposed to involve an enolized homoenolate as the key reactive intermediate, which is generated through ring opening of zinc cyclopropoxide and enolization of the resulting zinc homoenolate. The enolate moiety of this reactive species undergoes Michael addition to the alkylidenemalononitrile, which is followed by ring closure of the resulting α‐functionalized homoenolate and intramolecular cyclization between the cyclopropoxide and one of the cyano groups.
Radical Conjugate Addition of Acylsilane Enabled by Synergistic Photoredox and Lewis Acid Catalysis
Authors: Guo Ning , Luo Yao , Feng Lili , Liu Zhili , Cao Weidi , Feng Xiaoming 
Published: April 2023

AbstractA visible‐light‐induced acyl radical conjugate addition to electron‐deficient alkenes with acylsilane was realized by merging photoredox and Lewis acid catalysis under mild reaction conditions. Various tri‐ and tetra‐substituted furans were obtained with good yield (up to 97%) from α,β‐unsaturated ketones. Based on the experimental results and spectral analysis, a possible catalytic cycle involving 1,4‐conjugate addition/ring‐closure/arylation sequence was proposed. Beyond that, 1,6‐acyl radical conjugate addition topara‐quinone methides was also accomplished to deliver a series of α‐aryl ketones by using this synergistic catalysis protocol.
Insight into the Molecular Mechanism for Enhanced Longevity of Supramolecular Vesicular Photocatalysts
Authors: Liu Yannan , Zheng Fulu , Dai Haojie , Chen Chuanshuang , Chen Yajing , Wu Haolin , Yu Chunyang , Mai Yiyong , Frauenheim Thomas , Zhou Yongfeng 
Published: April 2023

AbstractSupramolecular self‐assembly is a promising strategy for stabilizing the photo‐sensitive components in photocatalysis. However, the underlying correlation between the enhanced photostability and supramolecular structure at the molecular level has not yet been fully understood. Herein, we develop a biomimetic vesicular membrane‐based polyporphyrin photocatalyst exhibiting excellent photocatalytic stability with at least activity time of 240 h in hydrogen generation. Time‐domain ab initio modelling together with transient absorption spectroscopy, visual frontier orbitals and Gibbs free energy calculation disclose that the ordered aggregation of porphyrin units in the vesicle membrane facilitates “hot” electron relaxation and the rapid dissipation of photo‐generated charges, thereby contributing to the longevity. This work deepens the molecular‐level understanding on photostability and photocatalytic mechanism of supramolecular photocatalysts.
The advances development of proton exchange membrane with high proton conductivity and balanced stability in fuel cells
Authors: Wei Peng , Sui Yang , Meng Xiaoyu , Zhou Qiong 
Published: April 2023

AbstractIn the proton exchange membrane fuel cell, proton exchange membrane (PEM) serves as both the main conductor of protons and the fuel‐blocking membrane. Thus, high proton conductivity and excellent stability are expected for PEMs at the same time. According to chemical structure, this review divides PEM into three groups. Recently, high‐performance PEM has been made possible by controlling chemical structure, organic–inorganic hybrid composite membranes, and nanofiber composite membranes. One of them, nanofiber composite membranes, is distinguished by long‐range order and is capable of achieving both strong proton conductivity with exceptional stability. The high‐performance PEM has been accomplished by the presence of an acid‐rich layer, acid–base interaction, and proton transport channel in PEMs are also summarized in this paper. We believe that our discussion will help the researcher create high‐performance PEM and pave the way for further developments in the field of energy materials as a whole.
Research on metallic contamination control of PFA injection molded fittings
Authors: Li Xuemei , Liu Fan , Xie Jun , Zhang Chengqian , Gao Ruoxiang , Lyu Chenxin , Zhao Peng 
Published: April 2023

AbstractIn chip manufacturing, ultraclean environment is essential during wet processes such as etching, cleaning, and other stages. The fittings used in the process require corrosion resistance, which are made of perfluoroalkoxy alkanes (PFA) by injection molding. Metallic contamination is one of the major impurities for ultraclean products. This study devotes to decreasing the metallic impurities of the parts and improving the wet processes environment. First, the preliminary experiment explored impurities distribution of the injection molds. By comparing the metallic contamination of the different molds' parts, it is shown that the impurities are evenly distributed. Subsequently, the influence of process parameters, including melt temperature, injection rate, screw speed, and holding pressure, on metallic contamination was investigated through the orthogonal experiment. The results indicate that the injection rate has the greatest impact on metallic contamination, followed by melt temperature. With process optimization, the smallest metallic contamination of 1.077 μg/m2 for pipe joints made of PFA can be achieved, which decreases by 56.3% compared with former results. This research indicates that adjusting parameters is a feasible and effective method to reduce the contamination during injection molding of ultraclean products, which provides another idea for improving the cleanliness of the environment in chip manufacturing.