bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Impact of COVID‐19 on Patients With Systemic Sclerosis Change Over Time?
Authors: Deibel Elisabeth , Carreira Patricia E. , Vonk Madelon , del Papa Nicoletta , Bečvář Radim , Guillén‐Del‐Castillo Alfredo , Campochiaro Corrado , Poormoghim Hadi , Liem Sophie , Lazzaroni Maria‐Grazia , Giollo Alessandro , Mekinian Arsène , de Vries‐Bouwstra Jeska , De Santis Maria , Balbir‐Gurman Alexandra , Mihai Carina , De Luca Giacomo , Moiseev Sergey , Zanatta Elisabetta , Foti Rosario , Rednic Simona , Denton Christopher , Cutolo Maurizio , Belloli Laura , Airo Paolo , Garzanova Liudmila , Moroncini Gianluca , İnanç Murat , Panopoulos Stylianos , Tandaipan Jose‐Luis , Chatelus Emmanuel , Rosato Edoardo , Kuwana Masataka , Yavuz Sule , Alegre‐Sancho Juan J. , Smith Vanessa , Szűcs Gabriella , Henes Joerg , Rodríguez‐Pintó Ignasi , Atzeni Fabiola , Spierings Julia , Truchetet Marie‐Elise , Milchert Marcin , Brito de Araujo Daniel , Riemekasten Gabriela , Bernardino Vera , Martin Thierry , del Galdo Francesco , Vacca Alessandra , Mendoza Fabian , Midtvedt Øyvind , Murdaca Giuseppe , Santiago Tânia , Codullo Veronica , Cacciapaglia Fabio , Walker Ulrich , Brunborg Cathrine , Tirelli Francesca , Allanore Yannick , Furst Daniel E. , Matucci Marco , Gabrielli Armando , Distler Oliver , Hoffmann‐Vold Anna‐Maria 
Published: September 2023

ObjectiveThe outcome of patients with COVID‐19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID‐19 over several waves.MethodsPatients with both SSc and COVID‐19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID‐19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc‐specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.ResultsA total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID‐19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.ConclusionThe outcome of patients with both SSc and COVID‐19 improved significantly over time because of intrinsic and extrinsic factors.
Advances of 2D‐Enabled Photothermal Materials in Hybrid Solar‐Driven Interfacial Evaporation Systems toward Water‐Fuel‐Energy Crisis
Authors: Irshad Muhammad Sultan , Arshad Naila , Asghar M. Sohail , Hao Yabin , Alomar Muneerah , Zhang Shaohui , Zhang Jian , Guo Jinming , Ahmed Iftikhar , Mushtaq Naveed , Shah M. A. K. Yousaf , Noureen Laila , Wageh S. , Al‐Hartomy Omar A. , Kalam Abul , Dao Van‐Duong , Wang Hao , Wang Xianbao , Zhang Han 
Published: September 2023

AbstractThe development of a multi‐functional solar‐driven interfacial evaporation (SDIE) system remains a significant challenge for its large‐scale applications. By taking advantage of high surface area, excellent young's moduli, anchoring/coupling capability, large absorption surface, strong absorption in the broadband solar spectrum, and efficient photothermal conversion efficiencies of 2D emerging materials (Xenes, Mxenes, etc.), hybrid SDIEs are developed to increase the use of solar energy beyond water production. This work aims to offer a systematic review of the recent advancement in 2D emerging materials except for graphene and their significant role in hybrid SDIEs to stimulate both fundamental and applied research on utilizing the underutilized auxiliary energy sources for future integrated water, energy, and environmental systems. For this purpose, first, the most recent progress in 2D photothermal materials is discussed, mainly including emerging Xenes, MXenes, and TMDs‐inspired hybrid SDIEs. Second, structural optimization strategies and modulation of the intrinsic photothermal performances of 2D emerging materials are highlighted. Third, the cutting‐edge conceptual designs developed in many hybrid applications such as thermoelectricity, salt recovery, and hydrogen production are broadly presented. Lastly, the current challenges and perspectives of 2D emerging materials and their hybrid evaporation structures are also mentioned.
Intrinsically Stretchable Subthreshold Organic Transistors for Highly Sensitive Low‐Power Skin‐Like Active‐Matrix Temperature Sensors
Authors: Kim Jun Su , Jeong Min Woo , Nam Tae Uk , Vo Ngoc Thanh Phuong , Jung Kyu Ho , Lee Tae Il , Oh Jin Young 
Published: September 2023

AbstractStretchable wearable sensors ultimately require low power consumption and high response to physiological signals with skin conformability. However, power‐response tradeoff and strain‐dependent sensing instability remain key challenges for electronic skin (e‐skin) sensors. Herein,an intrinsically stretchable organic subthreshold transistor operating at low voltage (−1 V) is presented, leading to ultralow power consumption (<1 nW) for highly sensitive skin‐like temperature sensory devices. The highly temperature‐dependent hopping transport of the fully stretchable subthreshold transistor exhibits high‐temperature sensitivity (9.4% °C−1) and excellent sensing stability up to 100% strain. A skin‐like subthreshold organic transistor active‐matrix array is successfully fabricated that sensed the surface temperature distribution under a 3D deformation.
Tissue Engineering of JAK Inhibitor‐Loaded Hierarchically Biomimetic Nanostructural Scaffold Targeting Cellular Senescence for Aged Bone Defect Repair and Bone Remolding
Authors: Liu Shi , Jia Xinlin , Hao Jina , Zhang Dapeng , Yang Shengchao , Dai Bin , Mao Yuanqing , Li Yongsheng 
Published: September 2023

AbstractCell senescence or apoptosis contributes to self‐failure and functional loss in specialized cells, leading to incapacity of the body to repair specific damages. Senescent bone marrow mesenchymal stem cells (BMSCs) lose their proliferative abilities and secrete senescence‐associated secretory phenotype (SASP), hindering their participation in bone defect repair. Hence, the effective suppression of cell senescence is crucial to restore the self‐repair capacity of body to treat bone defects. Since the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is associated with SASP secretion, herein, a new strategy is proposed to inhibit this pathway to suppress SASP secretion and enhance osteoblast activity based on a novel hierarchically biomimetic nanostructural electrospun scaffold with JAK inhibitors (JAKi, Ruxolitinib) loaded. As validated by in vitro and in vivo experiments, the JAKi loaded scaffold reduces SASP expression effectively and alleviates senescent cell burden, creating a pro‐regeneration microenvironment that enhances osteoblast function and mineralization activity as well as rejuvenating the bone repair capacity. These findings offer insights into the regulatory role of cellular senescence in bone aging and provide a new and effective strategy to treat age‐related bone defects by delivery of JAKi to locally aging bone defect sites.
Scalable All‐Inorganic Halide Perovskite Photoanodes with >100 h Operational Stability Containing Earth‐Abundant Materials
Authors: Daboczi Matyas , Cui Junyi , Temerov Filipp , Eslava Salvador 
Published: September 2023

AbstractThe application of halide perovskites in the photoelectrochemical generation of solar fuels and feedstocks is hindered by the instability of perovskites in aqueous electrolytes and the use of expensive electrode and catalyst materials, particularly in photoanodes driving kinetically slow water oxidation. Here, solely earth‐abundant materials are incorporated to fabricate a CsPbBr3‐based photoanode that reaches a low onset potential of +0.4 VRHE and 8 mA cm−2 photocurrent density at +1.23 VRHE for water oxidation, close to the radiative efficiency limit of CsPbBr3. This photoanode retains 100% of its stabilized photocurrent density for more than 100 h of operation by replacing once the inexpensive graphite sheet upon signs of deterioration. The improved performance is due to an efficiently electrodeposited NiFeOOH catalyst on a protective self‐adhesive graphite sheet, and enhanced charge transfer achieved by phase engineering of CsPbBr3. Devices with >1 cm2 area, and low‐temperature processing demonstrate the potential for low capital cost, stable, and scalable perovskite photoanodes.
Bioorthogonal Guided Activation of cGAS‐STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging
Authors: Cui Minhui , Tang Dongsheng , Wang Bin , Zhang Hanchen , Liang Ganghao , Xiao Haihua 
Published: September 2023

AbstractPhotodynamic therapy (PDT) and photothermal therapy (PTT) leverage reactive oxygen species (ROS) and control local hyperthermia by photosensitizer to perturb intracellular redox equilibrium, inducing DNA damage in both mitochondria and nucleus, activating the cGAS‐STING pathway, ultimately eliciting antitumor immune responses. However, current photosensitizers are encumbered by limitations such as suboptimal tumor targeting, aggregation‐caused quenching (ACQ), and restricted excitation and emission wavelengths. Here, this work designs novel nanoparticles based on aggregation‐induced emission (AIE) photosensitizer (BODTPE) for targeted tumor therapy and near‐infrared II fluorescence imaging (NIR‐II FLI) with enhanced PDT/PTT effects. BODTPE is employed as a monomer, dibenzocyclooctyne (DBCO)‐PEG2k‐amine serving as an end‐capping polymer, to synthesize a BODTPE‐containing polymer (DBD). Further, through self‐assembly, DBD and mPEG‐DSPE2k combined to form nanoparticles (NP‐DBD). Notably, the DBCO on the surface of NP‐DBD can react with azide groups on cancer cells pretreated with Ac4ManNAz through a copper‐free click reaction. This innovative formulation led to targeted accumulation of NP‐DBD within tumor sites, a phenomenon convincingly demonstrated in murine tumor models subjected to N‐azidoacetylmannosamine‐tetraacylated (Ac4ManNAz) pretreatment. Significantly, NP‐DBD exhibits a multifaceted effect encompassing PDT/PTT/NIR‐II FLI upon 808 nm laser irradiation, thereby better activating the cGAS‐STING pathway, culminating in a compelling tumor inhibition effect augmented by robust immune modulation.
Biodegradation of Oxide Nanoparticles in Apoferritin Protein Media: A Systematic Electrochemical Approach
Authors: Rahimi Ehsan , Kim Donghoon , Offoiach Ruben , Sanchis‐Gual Roger , Chen Xiang‐Zhong , Taheri Peyman , Gonzalez‐Garcia Yaiza , Mol Johannes M. C. , Fedrizzi Lorenzo , Pané Salvador , Lekka Maria 
Published: September 2023

AbstractFunctional oxide nanoparticles are extensively utilized in the last decades for biomedical purposes due to their unique functional properties. Nevertheless, their biodegradation mechanism by biological species, particularly by proteins at oxide/protein interfaces, still remains limited. Here, a systematic approaches is provided to investigate electrochemical behavior, electronic properties, and biodegradation mechanism of cobalt ferrite (CFO) and cobalt ferrite‐bismuth ferrite (CFO‐BFO) core‐shell nanoparticles in apoferritin‐containing media. Scanning Kelvin probe force microscopy results indicate that the presence of a thin shell (≈5 nm) of BFO on CFO causes a significant increase in surface potential. The potentiodynamic polarization measurements in different solutions showed higher anodic current densities for both samples when decreasing pH and increasing apoferritin concentration. Notably, CFO‐BFO exhibits lower anodic current densities than CFO due to a slightly higher flat band potential and lower donor density distribution on CFO‐BFO than on CFO, which results in lower electrochemical activity. Long‐term monitoring reveals that biodegradation of both nanoparticles is accelerated by high apoferritin concentrations and acidic media, resulting in the decrease of electrochemical potentials and impedance values, and enhancement of metal ion release. Thus, this systematic biodegradation study can help to predict the lifespan and toxicity of these functional nanoparticles in biological environments.
Selective Catalysts for the Homogeneous Semi‐Hydrogenation
Authors: Jannsen Nora , Pribbenow Cornelia , Selle Carmen , Drexler Hans‐Joachim , Müller Marc‐André , Medlock Jonathan A. , Bonrath Werner , Heller Detlef 
Published: September 2023

AbstractAn efficient and highly selective semi‐hydrogenation of terminal alkynes to alkenes using neutral dimeric rhodium(I) complexes of the type [Rh(μ‐Cl)(PP)]2 is presented. Dehydroisophytol (DIP) was chosen as the alkyne for this study because of its high importance in the industrial production of synthetic vitamin E. Excellent selectivity of over 91% towards the alkene was achieved with known and new rhodium catalysts. No deactivation was observed for the [Rh(μ‐Cl)(PP)]2 complexes and the molar Rh:DIP ratio could be increased to 1:20 000, and importantly, no reduction in selectivity was observed. The results presented open the door to the industrial application of homogeneous rhodium complexes in the semi‐hydrogenation of terminal alkynes.
Probing the Effect of Acceptor Moiety Engineering in Carbazole‐Based Hole‐Transporting Materials for Efficient Perovskite Solar Cells
Authors: Zahid Waqar Ali , Ahmad Muhammad Fiaz , Akram Waqas , Shaaban Ibrahim A. , Assiri Mohammed A. , Elmushyakhi Abraham , Iqbal Javed 
Published: September 2023

AbstractComputational studies on the relationship between the molecular structures and properties of hole‐transporting materials (HTMs) are an effective way to find promising HTMs for high‐performance perovskite solar cells (PSCs). Herein, a series of carbazole‐based five HTMs with diphenyl pyridine‐based side arms (namely CDPC, CDPP, CDPI, CDPT, and CDPM) are designed. The results indicated that designed HTMs have deeper HOMO & LUMO levels, high absorption coefficient, low recombination rate, superior solubility, and comparable stability compared to the reference molecule which is based on carbazole diphenyl pyridine (CDP) for high‐efficiency perovskite solar cells (PSCs). The design molecules exhibit smaller exciton binding energies, which demonstrates that the electron‐hole pairs are easily dissociated into the free charge that facilitates the hole transport for PSCs. The results of low hole reorganization energy and the high total amount of charge transfer indicated that designed HTMs have effective hole transport ability. In the future, it is expected that this studies will demonstrate the potential of designed HTMs in the manufacture of effective PSCs in the solar industry.
Optimizing Piezoelectric Coefficient in PVDF Fibers: Key Strategies for Energy Harvesting and Smart Textiles
Authors: Sukumaran Sunija , Szewczyk Piotr K. , Knapczyk‐Korczak Joanna , Stachewicz Urszula 
Published: September 2023

AbstractWith the advancement in smart electronic devices and self‐powered devices, the demand for piezoelectric polymers has found potential research interest. Among these, electrospun polyvinylidene fluoride (PVDF) fibers have gained attention for energy harvesting due to their flexibility and higher piezoelectric coefficient. In the current work, various methods are compared to enhance PVDF's piezoelectric properties, including different solvents (DMAc, DMF), conductive filler (rGO), and annealing as post‐treatment. The results indicate that PVDF/rGO fibers in DMAc solvent exhibit the highest β phase fraction and crystallinity. Moreover, for the first time, the piezoelectric properties of PVDF/rGO electrospun single fiber is presented using high voltage switching spectroscopy piezoelectric force microscopy (HVSS‐PFM). The highest piezoelectric coefficient (d33) is measured for PVDF/DMAc‐rGO composite fibers. Notably, PVDF/rGO in DMAc solvent significantly improves the piezoelectric coefficient, leading to a remarkable fourfold increase in power density compared to pure PVDF, making it a promising material for energy harvesting applications.
Identifying individuals with non‐Alzheimer's disease co‐pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease
Authors: Tosun Duygu , Yardibi Ozlem , Benzinger Tammie L. S. , Kukull Walter A. , Masters Colin L. , Perrin Richard J. , Weiner Michael W. , Simen Arthur , Schwarz Adam J. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2023

AbstractINTRODUCTIONBiomarkers remain mostly unavailable for non‐Alzheimer's disease neuropathological changes (non‐ADNC) such as transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy, Lewy body disease (LBD), and cerebral amyloid angiopathy (CAA).METHODSA multilabel non‐ADNC classifier using magnetic resonance imaging (MRI) signatures was developed for TDP‐43, LBD, and CAA in an autopsy‐confirmed cohort (N = 214).RESULTSA model using demographic, genetic, clinical, MRI, and ADNC variables (amyloid positive [Aβ+] and tau+) in autopsy‐confirmed participants showed accuracies of 84% for TDP‐43, 81% for LBD, and 81% to 93% for CAA, outperforming reference models without MRI and ADNC biomarkers. In an ADNI cohort (296 cognitively unimpaired, 401 mild cognitive impairment, 188 dementia), Aβ and tau explained 33% to 43% of variance in cognitive decline; imputed non‐ADNC explained an additional 16% to 26%. Accounting for non‐ADNC decreased the required sample size to detect a 30% effect on cognitive decline by up to 28%.DISCUSSIONOur results lead to a better understanding of the factors that influence cognitive decline and may lead to improvements in AD clinical trial design.
Site Engineering of Covalent Organic Frameworks for Regulating Peroxymonosulfate Activation to Generate Singlet Oxygen with 100 % Selectivity
Authors: Weng Zonglin , Lin Yuanfang , Guo Siyuan , Zhang Xinfei , Guo Qin , Luo Yu , Ou Xinwen , Ma Jinxing , Zhou Yang , Jiang Jin , Han Bin 
Published: September 2023

AbstractSinglet oxygen (1O2) is an excellent reactive oxygen species (ROSs) for the selective conversion of organic matter, especially in advanced oxidation processes (AOPs). However, due to the huge dilemma in synthesizing single‐site type catalysts, the control and regulation of 1O2 generation in AOPs is still challenging and the underlying mechanism remains largely obscure. Here, taking advantage of the well‐defined and flexibly tunable sites of covalent organic frameworks (COFs), we report the first achievement in precisely regulating ROSs generation in peroxymonosulfate (PMS)‐based AOPs by site engineering of COFs. Remarkably, COFs with bipyridine units (BPY‐COFs) facilitate PMS activation via a nonradical pathway with 100 % 1O2, whereas biphenyl‐based COFs (BPD‐COFs) with almost identical structures activate PMS to produce radicals (⋅OH and SO4⋅−). The BPY‐COFs/PMS system delivers boosted performance for selective degradation of target pollutants from water, which is ca. 9.4 times that of its BPD‐COFs counterpart, surpassing most reported PMS‐based AOPs systems. Mechanism analysis indicated that highly electronegative pyridine‐N atoms on BPY‐COFs provide extra sites to adsorb the terminal H atoms of PMS, resulting in simultaneous adsorption of O and H atoms of PMS on one pyridine ring, which facilitates the cleavage of its S−O bond to generate 1O2.
Site Engineering of Covalent Organic Frameworks for Regulating Peroxymonosulfate Activation to Generate Singlet Oxygen with 100 % Selectivity
Authors: Weng Zonglin , Lin Yuanfang , Guo Siyuan , Zhang Xinfei , Guo Qin , Luo Yu , Ou Xinwen , Ma Jinxing , Zhou Yang , Jiang Jin , Han Bin 
Published: September 2023

AbstractSinglet oxygen (1O2) is an excellent reactive oxygen species (ROSs) for the selective conversion of organic matter, especially in advanced oxidation processes (AOPs). However, due to the huge dilemma in synthesizing single‐site type catalysts, the control and regulation of 1O2 generation in AOPs is still challenging and the underlying mechanism remains largely obscure. Here, taking advantage of the well‐defined and flexibly tunable sites of covalent organic frameworks (COFs), we report the first achievement in precisely regulating ROSs generation in peroxymonosulfate (PMS)‐based AOPs by site engineering of COFs. Remarkably, COFs with bipyridine units (BPY‐COFs) facilitate PMS activation via a nonradical pathway with 100 % 1O2, whereas biphenyl‐based COFs (BPD‐COFs) with almost identical structures activate PMS to produce radicals (⋅OH and SO4.−). The BPY‐COFs/PMS system delivers boosted performance for selective degradation of target pollutants from water, which is ca. 9.4 times that of its BPD‐COFs counterpart, surpassing most reported PMS‐based AOPs systems. Mechanism analysis indicated that highly electronegative pyridine‐N atoms on BPY‐COFs provide extra sites to adsorb the terminal H atoms of PMS, resulting in simultaneous adsorption of O and H atoms of PMS on one pyridine ring, which facilitates the cleavage of its S−O bond to generate 1O2.
Analysis of mechanical and flame‐retardant properties of flexible polyurethane foams
Authors: Kim Young Shin , Jeon Euy Sik 
Published: September 2023

AbstractIn this study, the mechanical and flame‐retardant properties of flexible polyurethane foams (FPUF) were analyzed as a function of the type of flame retardant. FPUF containing equal amounts of two halogenated flame retardants (tris 2‐cloropropyl phosphate [TCPP] and phosphinyl alkyl phosphate ester) and three halogen‐free flame retardants (melamine, melamine cyanurate, and expandable graphite) were considered. The foaming properties of these samples were analyzed by studying the rise time and settling rate using cup foaming. Square foaming was used to analyze the mechanical properties, including density, elongation, tensile strength, and tear strength. In addition, Fourier‐transform infrared spectroscopy was performed, and flame retardancy was evaluated using a horizontal flame test and the limited oxygen index. A cone calorimeter test was also performed to evaluate the combustion characteristics. In FPUF containing the same ratio of flame retardant (15% of the total polyol), the properties of urethane foam blended with expandable graphite were improved; the tensile strength of this blend is 20% higher than that of samples containing melamine, and its peak heat release showed a 70% reduction compared to that of samples containing TCPP. These findings provide valuable reference information for developing flame retardants for fire safety FPUF in the near future.