bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial distribution analysis and driving factors of traditional villages in Henan province: a comprehensive approach via geospatial techniques and statistical models
Authors: Liu Wenxiang , Xue Ying , Shang Cun 
Published: August 2023

Abstract
Traditional villages are repositories for preserving human artifacts and cultural heritage. An investigation of the spatial distribution characteristics and factors influencing traditional villages in provincial administrative regions can provide new insights regarding the protection of traditional villages and rural development. This study focused on 275 traditional villages in Henan Province. Using ArcGIS and GeoDa software, we analysed the spatial autocorrelation and heterogeneity of the nearest neighbour index, Gini coefficient, Moran’s I, and kernel density of the villages. Additionally, in conjunction with the Python sklearn library and GeoDetector, 15 indicators were selected to construct a decision tree model, spatial lag regression model, and geographic detector. Then the influence and interaction mechanisms of each indicator were analysed. The results revealed that (1) the spatial distribution of traditional villages in Henan Province was clustered and uneven, with a spatial layout comprising “3 high-density areas + 1 medium-density belt”; (2) overall, the number of traditional villages was negatively correlated with altitude, slope, rainfall, population density, proportion of the minority population, and historical-cultural intensity; and (3) the decision tree model results demonstrated that the selected 15 indicators had good predictive ability and that population density was particularly important. The spatial lag regression model results showed that the spatial distribution of traditional villages was positively correlated with distance from rivers, urbanization rate, and tourism resources, and negatively correlated with population density, per capita GRP, historical-cultural intensity, and NDVI. (4) The GeoDetector results indicated that historical-cultural intensity and population density were the two factors with the most significant explanatory power for the spatial differentiation of traditional villages in Henan Province. In terms of interactive factors, population density

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population was the strongest interactive driving force, followed by population

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historical-cultural intensity.
Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk
Authors: Furugen Ayako , Nishimura Ayako , Umazume Takeshi , Ishikawa Hina , Narumi Katsuya , Kobayashi Masaki 
Published: August 2023

Abstract
Background
Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk. To facilitate studies on the safety of lacosamide use during breastfeeding, we aimed to develop a method to quantify lacosamide in human breast milk and plasma using ultra-performance liquid chromatography/tandem mass spectrometry.

Methods
Fifty microliters of breast milk or plasma was used, and samples were prepared by protein precipitation using methanol containing lacosamide-d3 as an internal standard (IS). Chromatography was performed using an ACQUITY HSS T3 column with an isocratic flow of 10 mM ammonium acetate solution/methanol (70:30, v/v). Lacosamide and IS were detected by multiple reaction monitoring in positive ion electrospray mode. The run time was 3.5 min.

Results
Calibration curves were linear and in the range of 0.5 to 100 ng/mL both in breast milk and plasma. The validation assessment indicated that precision, accuracy, matrix effects, selectivity, dilution integrity, and stability were acceptable. The developed method was successfully applied to quantify lacosamide in breast milk and plasma obtained from a volunteer who had been orally administered lacosamide twice a day (100 mg × 2). Relative infant dose of lacosamide was estimated to be 14.6% in breast milk at five time points.

Conclusions
We developed a simple and robust method to quantify of lacosamide in human breast milk and plasma. This method could be useful for in future studies investigating the safety of lacosamide use during breastfeeding.
Acceptability and readiness to promote human papillomavirus vaccination at ages 9–10 years: a feasibility study among North Carolina clinics
Authors: Vielot Nadja A. , Lane Robyn M. , Loefstedt Kaitlyn , Cunningham Jennifer L. , Everson Jason , Tiller Eli , Johnson Patel Sarah E. , Smith Jennifer S. 
Published: August 2023

AbstractWhile 9-valent human papillomavirus (HPV) vaccination is approved by the US Food and Drug Administration for use in adolescents as young as age 9, providers typically recommend it at ages 11–12. Studies suggest that recommending HPV vaccination at 9 or 10 years of age could increase up-to-date vaccination by age 13, which could especially benefit rural populations with reduced access to primary health care and lower HPV vaccination coverage than urban areas. This study aimed to assess the feasibility of the age-9 recommendation of HPV vaccination in rural clinics. We conducted in-depth interviews with providers and staff from two primary care clinics in central North Carolina to understand attitudes toward recommending HPV vaccination to 9- and 10-year-olds. All interviewees agreed that HPV vaccination was important for cancer prevention and should be recommended before the onset of sexual activity, agreeing that HPV vaccination could be initiated before age 11 to improve timeliness and completion of the vaccination series. However, opinions were mixed on whether HPV vaccination should be initiated as young as 9 years old. Two key informants recruited from two university-affiliated clinics described their experiences recommending HPV vaccination to 9- and 10-year-olds, including a modified vaccination schedule that promotes HPV vaccination during routine well-child visits, prior to pubertal onset, and alongside other recommended adolescent vaccines. Age-9 recommendation and administration of HPV vaccination is possible with minimal changes to current clinical practices and could increase the convenience and acceptability of HPV vaccination in under-vaccinated settings.
German guidelines on community-acquired acute bacterial meningitis in adults
Authors: Klein Matthias , Abdel-Hadi Carsten , Bühler Robert , Grabein Beatrice , Linn Jennifer , Nau Roland , Salzberger Bernd , Schlüter Dirk , Schwager Konrad , Tumani Hayrettin , Weber Jörg , Pfister Hans-Walter 
Published: August 2023

AbstractIntroductionThe incidence of community-acquired acute bacterial meningitis has decreased during the last decades. However, outcome remains poor with a significant proportion of patients not surviving and up to 50% of survivors suffering from long-term sequelae. These guidelines were developed by theDeutsche Gesellschaft für Neurologie(DGN) under guidance of theArbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften(AWMF) to guide physicians through diagnostics and treatment of adult patients with acute bacterial meningitis.RecommendationsThe most important recommendations are: (i) In patients with suspected acute bacterial meningitis, we recommend that lumbar cerebrospinal fluid (with simultaneous collection of serum to determine the cerebrospinal fluid-serum glucose index and blood cultures) is obtained immediately after the clinical examination (in the absence of severely impaired consciousness, focal neurological deficits, and/or new epileptic seizures). (ii) Next, we recommend application of dexamethasone and empiric antibiotics intravenously. (iii) The recommended initial empiric antibiotic regimen consists of ampicillin and a group 3a cephalosporin (e.g., ceftriaxone). (iv) In patients with severely impaired consciousness, new onset focal neurological deficits (e.g. hemiparesis) and/or patients with newly occurring epileptic seizures, we recommend that dexamethasone and antibiotics are started immediately after the collection of blood; we further recommend that —if the imaging findings do not indicate otherwise —a lumbar CSF sample is taken directly after imaging. (v) Due to the frequent occurrence of intracranial and systemic complications, we suggest that patients with acute bacterial meningitis are treated at an intensive care unit in the initial phase of the disease. In the case of impaired consciousness, we suggest that this is done at an intensive care unit with experience in the treatment of patients with severe CNS diseases.ConclusionsThe German S2k-guidelines give up to date recommendations for workup, diagnostics and treatment in adult patients with acute bacterial meningitis.
3D bioprinting of collagen-based materials for oral medicine
Authors: Yang Bosen , Liu Hai , Jiang Linli , Zeng Yiwei , Han Yiyuan , Sha Chuanlu , Xie Xin , Li Hui , Zhou Jiajing , Lin Wei 
Published: August 2023

AbstractOral diseases have emerged as one of the leading public health challenges globally. Although the existing clinical modalities for restoration of dental tissue loss and craniomaxillofacial injuries can achieve satisfactory therapeutic results, they cannot fully restore the original complex anatomical structure and physiological function of the tissue. 3D printing of biological tissues has gained growing interest in the field of oral medicine with the ability to control the bioink component and printing structure for spatially heterogeneous repairing constructs, holding enormous promise for the precise treatment of oral disease. Particularly, collagen-based materials have been recognized as promising biogenic bioinks for the regeneration of several tissues with high cell-activating and biocompatible properties. In this review, we summarize 3D printing methods for collagen-based biomaterials and their mechanisms. Additionally, we highlight the animal sources of collagen and their characteristics, as well as the methods of collagen extraction. Furthermore, this review provides an overview of the 3D bioprinting technology for the regeneration of the pulpal nerve and blood vessels, cartilage, and periodontal tissue. We envision that this technique opens up immense opportunities over the conventional ones, with high replicability and customized function, which can ultimately promote effective oral tissue regeneration.
Graphical Abstract
Cognitive functions in Arabic-speaking children with velopharyngeal insufficiency and their impact on speech intelligibility
Authors: Aref Essam-Eldin M. , Hameed Zeinab A. Abdel , Mohamed Hanan A. 
Published: August 2023

Abstract
Background
Patients with orofacial cleft are at high risk for neurobehavioral problems including learning disability, impaired language function, psychosocial adjustment issues, and persistently reduced academic achievement. All these factors may be related to decrease intellectual abilities of those patients. The presence of velopharyngeal insufficiency (VPI) leads to affection of speech intelligibility due to atypical consonant productions, abnormal nasal resonance, nasal air emission, compensatory articulatory mechanism, and facial grimace.

Objective
This study aimed at assessing the cognitive functions of patients with (VPI) and their effect on speech intelligibility.

Methodology
Fifty patients with (VPI) were selected from the Outpatient Clinic of the Phoniatric Unit in Assiut University Hospital. All patients were evaluated by protocol of nasality assessment including auditory perceptual assessment of speech, assessment of overall intelligibility of speech, nasoendoscopy, and psychometric evaluation.

Results
The mean intelligence quotient (IQ) of patients with VPI was 75.2 ± 14.5 with a range between 41 and 107. The main defect was present in quantitative potential and then verbal ability followed by visual ability with memory having the highest mean. Patients with repaired cleft palate had the highest score (86.53 ± 9.96), while the least score was reported among those with velopharyngeal disproportion (72.50 ± 9.59). There was a nonsignificant negative correlation between IQ degree and speech unintelligibility (p = 0.82).

Conclusion
About half of the patients with (VPI) have below average mentality. Patients with repaired cleft palate had the highest (IQ) score. Increased (IQ) score was accompanied by decreased speech unintelligibility, although it does not reach the level of significance.
The developmental dynamics of the human male germline
Authors: Hargy John , Sasaki Kotaro 
Published: August 2023

ABSTRACTMale germ cells undergo a complex sequence of developmental events throughout fetal and postnatal life that culminate in the formation of haploid gametes: the spermatozoa. Errors in these processes result in infertility and congenital abnormalities in offspring. Male germ cell development starts when pluripotent cells undergo specification to sexually uncommitted primordial germ cells, which act as precursors of both oocytes and spermatozoa. Male-specific development subsequently occurs in the fetal testes, resulting in the formation of spermatogonial stem cells: the foundational stem cells responsible for lifelong generation of spermatozoa. Although deciphering such developmental processes is challenging in humans, recent studies using various models and single-cell sequencing approaches have shed new insight into human male germ cell development. Here, we provide an overview of cellular, signaling and epigenetic cascades of events accompanying male gametogenesis, highlighting conserved features and the differences between humans and other model organisms.
Synthesis of β-Enaminones via Palladium-catalyzed Dehydrogenative β-Amination of Saturated Ketones
Authors: Ueno Satoshi , Yasuoka Shohei , Minamikawa Ryo , Kuwano Ryoichi 
Published: August 2023

Abstract
A palladium-catalyzed method was developed for the synthesis of β-enaminones from saturated ketones using allyl acetate. In this reaction, allyl acetate acts as a hydrogen scavenger to α,β-dehydrogenate saturated ketones in the presence of a palladium catalyst and diamine ligand. This reaction achieved internal β-carbon–nitrogen bond formation for the first time via the dehydrogenation/conjugate addition protocol, eliminating the need to isolate unstable α,β-unsaturated ketones generated in the reaction.
ASEAN as network governance: An alternative lens to evaluate policymaking and performance
Authors: Sundram Pushpanathan 
Published: August 2023

Background: This article offers a new perspective of the Association of Southeast Asian Nations (ASEAN) as network governance (NG) using the policy network theory (PNT) for the analysis. Methods: Two case studies were selected from the ASEAN Community to examine the applicability and effectiveness of NG in promoting ASEAN cooperation. These case studies were chosen due to their prominence and the prevalence of critical comments about their effectiveness in promoting cooperation. The content analysis utilised primary data from ASEAN reports, documents, research articles and processes, and studies on NG and policy networks. A literature review was conducted using online academic databases and ASEAN-related websites. The search covered the period from June 2019 to March 2021, with further searches conducted between January and July 2023. These data collection efforts provided a robust analysis of the case studies within the NG and ASEAN integration contexts. Results: The findings show ASEAN as a hybrid structure which has supported its survival and relevance. This approach provides legitimacy for ASEAN globally by purposefully adopting structures similar to the EU without the supranational elements. It also showcases ASEAN’s motivation for asserting its centrality. Adopting a hybrid structure has led to ASEAN's soft institutionalisation, driven by its norms and characterised by a less empowered secretariat, where the member states are the decision-makers and implementors of policies. It opens a pathway to recognising ASEAN states’ autonomy, where the actors’ will and interests affect decision-making and defines performance. Conclusions: This article demonstrates NG's viability in promoting ASEAN's centrality in regional cooperation and institutional arrangements and allows for a nuanced assessment of its performance considering the context of the issue and ASEAN's history and emphasising the member states' primacy in policymaking. The NG framework contributes to ASEAN’s legitimacy, regional cooperation and performance despite its inherent limitations.
Complementary and alternative medicine use by Bangladeshi adult patients with diabetes and hypertension: A multicenter study
Authors: Mohsin Faroque Md. , Gupta Sudipta Das , Hasan Shahriar , Mahmud Sarah Tahera , Yasmin Irin , Hossain Md. Anwar , Alam Md. Mahbub , Islam Md. Nazrul 
Published: August 2023

Background: The use of complementary and alternative medicine (CAM) in Bangladesh is widespread, but scarce information exists about its use in treating hypertension and diabetes in adults. The study aimed to understand the distribution and determinants of CAM use among Bangladeshi adult patients with hypertension and diabetes. Methods: This multicenter cross-sectional study was conducted among 400 adult patients with hypertension (n=200) and diabetes (n=200). Data were collected from two specialised diabetes and hypertension treatment centers. Interviews were used to gather socio-demographic data, while medical records were used to obtain information on hypertension and diabetes. A multivariate logistic regression model was used to identify the most influential predictors of CAM usage. Results: Overall, 29% (n=116) of patients used CAM for diabetes and hypertension, with 37.5% (n=41) for hypertension and 37.5% (n=75) for diabetes. Older patients (aged >59) were 7.5 times more likely to use CAM (OR=7.527; 95% CI: 3.224 to 17.574, p<0.001) than young adults (aged <35 years). The currently employed patients were less likely to be CAM users (OR=0.429; 95% CI: 0.264 to 0.697, p<0.001) than the unemployed patients. It was less common for patients from nuclear families to use CAM (OR=0.178; 95% CI: 0.111 to 0.286, p<0.001) than those from extended families. Patients with hypertension were less likely (OR=0.430; 95% CI: 0.275 to 0.672, p<0.001) to be CAM users than patients with diabetes. Most of the CAM users were influenced by media and family members. The most common reasons for CAM use were its perceived effectiveness, fewer side effects, and low cost. Conclusions: The study observed a high prevalence of CAM users among patients with hypertension and diabetes. The most common CAM modalities were homeopathy, ayurveda and unani medicine. The findings suggest future directions for research and have practical implications for chronic disease treatment.
Fast Continuous and Integer L-Shaped Heuristics Through Supervised Learning
Authors: Larsen Eric , Frejinger Emma , Gendron Bernard , Lodi Andrea 
Published: August 2023

We propose a methodology at the nexus of operations research and machine learning (ML) leveraging generic approximators available from ML to accelerate the solution of mixed-integer linear two-stage stochastic programs. We aim at solving problems where the second stage is demanding. Our core idea is to gain large reductions in online solution time, while incurring small reductions in first-stage solution accuracy by substituting the exact second-stage solutions with fast, yet accurate, supervised ML predictions. This upfront investment in ML would be justified when similar problems are solved repeatedly over time—for example, in transport planning related to fleet management, routing, and container yard management. Our numerical results focus on the problem class seminally addressed with the integer and continuous L-shaped cuts. Our extensive empirical analysis is grounded in standardized families of problems derived from stochastic server location (SSLP) and stochastic multi-knapsack (SMKP) problems available in the literature. The proposed method can solve the hardest instances of SSLP in less than 9% of the time it takes the state-of-the-art exact method, and in the case of SMKP, the same figure is 20%. Average optimality gaps are, in most cases, less than 0.1%. History: Accepted by Alice Smith, Area Editor (for this paper) for Design and Analysis of Algorithms–Discrete. Funding: Financial support from the Institut de Valorisation des Données (IVADO) Fundamental Research Project Grants [project entitled “Machine Learning for (Discrete) Optimization”]; Canada Research Chairs; the Natural Sciences and Engineering Research Council of Canada [Collaborative Research and Development Grant CRD-477938-14]; and the Canadian National Railway Company Chair in Optimization of Railway Operations at Université de Montréal is gratefully acknowledged. E. Frejinger holds a Canada Research Chair. Computations were made on the supercomputer Béluga, managed by Calcul Québec and Digital Research Alliance of Canada. The operation of this supercomputer is funded by the Canada Foundation for Innovation; the Ministère de l’Économie, de la Science et de l’Innovation du Québec; and the Fonds de Recherche du Québec – Nature et Technologies.
Employee Satisfaction, Labor Market Flexibility, and Stock Returns Around the World
Authors: Edmans Alex , Pu Darcy , Zhang Chendi , Li Lucius 
Published: August 2023

Studying 30 countries, we find that the link between employee satisfaction and stock returns is significantly increasing in a country’s labor market flexibility. This result is consistent with employee satisfaction having greater recruitment, retention, and motivation benefits where firms face fewer hiring and firing constraints and employees have greater ability to respond to satisfaction. Labor market flexibility also increases the link between employee satisfaction and current valuation ratios, future profitability, and future earnings surprises, inconsistent with omitted risk factors and identifying channels through which employee satisfaction may affect stock returns. The findings have implications for the differential profitability of socially responsible investing strategies around the world—in particular, the importance of considering institutional factors when forming such strategies. This paper was accepted by Lin William Cong, finance. Funding: This work was supported by Deloitte Institute of Innovation and Entrepreneurship. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4889 .