bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Resilience in Times of Multiple Crisis
Authors: Pinkwart Andreas , Schingen Gideon , Pannes Anna-Tina , Schlotböller Dirk 
Published: December 2022

AbstractDue to the trend towards more frequent and multiple crises, it is essential for enterprises as well as for states and entire economic areas to develop strategies to improve resilience. In this article, existing challenges and conceivable strategies for improving resilience will be outlined from a microeconomic as well as from a macroeconomic perspective. To mitigate vulnerabilities of Supply Chains in the last decades, drivers for improving Supply Chain resilience have been explored. They are presented as contributing to building resilience on the micro level. On the macro level, opportunities and limits of current approaches for strategic independence are discussed. In terms of a new regulatory policy, a rescue of honour for global cooperation and free trade is proposed by the authors.
Optimization of keratinase production by keratinolytic fungus Chrysosporium tropicum and its potentiality in bidegradation of chicken feathers
Authors: Koutb Mostafa M. , Hassan Elhagag A. , Morsy Fatthy M. , Bagy Magdy M. K. 
Published: December 2022

AbstractThe current study has been designed to investigate the possible biodegradtion of native keratin by fungi isolated from chicken feathers collected from chicken farms in Egypt. Out of 56 fungal isolates 23 species and 2 species varieties showed different degrees of keratinolytic activity, with Chrysosporium tropicum showing the highest keratinase productivity (23.15 U/ml) as well as the highest value of specific activity for keratinase (197.90 U/mg protein) indicating a great degree of purity for the enzyme. Our present study indicates that the highest production of keratinase by C. tropicum was recorded at pH 8 and a temperature of 35 °C during a period of 20 days. In addition the optimal value of ionic strength for keratinase production was 100 mM NaCl. Monitoring the influence of constituents deprivation from basal salt medium on production of keratinase enzyme showed that K+, Fe2+, Mg2+, Ca2+ and Zn2+ were necessary for keratinase production. Sulfur deprivation has no significant influence on keratinase production. Keratinase activity of C. tropicum showed that, the optimal values of temperature and ionic strength were 35–40 °C and 80 mM NaCl, individually. The optimum pH range was (7.8–9). These promising findings demonstrate a high potentiality of C. tropicum keratinase in keratin proteolysis, suggesting that keratinase producing isolates of C. tropicum may be suitable as a biodegradation agent.
Some Results for Intuitionistic Fuzzy Inequality
Authors: Peng Xindong , Garg Harish , Luo Zhigang 
Published: December 2022

AbstractIntuitionistic fuzzy sets, characterized by membership degree $$\mu $$
μ
, non-membership degree $$\upsilon $$
υ
and hesitation degree $$\pi $$
π
, are a meaningful extension of fuzzy set. Inequalities on intuitionistic fuzzy sets/values are very important in solving real problems. In this paper, some inequalities on intuitionistic fuzzy sets are derived from operations. Moreover, three unweighted intuitionistic fuzzy aggregation operators, including unweighted intuitionistic fuzzy Square, unweighted intuitionistic fuzzy Arithmetic and unweighted intuitionistic fuzzy Geometric, are developed. Later, some corresponding inequality relations on them are deeply explored. Finally, some inequalities on intuitionistic fuzzy value are constructed by equality $$\mu +\upsilon +\pi =1$$

μ
+
υ
+
π
=
1

in critical definition and proved by some existing famous inequalities, which provide a novel basis for the intuitionistic fuzzy inequalities in operations and aggregation operators.
Associations between participation and personal factors in community-dwelling adults post-stroke
Authors: Hoyle Melanie , Meredith Pamela , Ownsworth Tamara , Khan Asaduzzaman , Gustafsson Louise 
Published: December 2022

AbstractPurpose:To examine associations between post-stroke participation and personal factors, including demographic characteristics, self- and threat appraisals, and personality variables.Methods:An exploratory cross-sectional study with purpose-designed survey was completed online or via mail. The survey was comprised of demographic and health-related questions and multiple questionnaires, including the Stroke Impact Scale Version 3.0 (SISv3) (participation/perceived recovery), Community Integration Questionnaire (CIQ) (participation), Head Injury Semantic Differential III (pre- vs post-stroke self-concept/self-discrepancy), Appraisal of Threat and Avoidance Questionnaire (threat appraisal), Life Orientation Test – Revised (optimism) and Relationships Questionnaire (adult attachment style) that measured variables of interest. Sixty-two participants, aged 24–96 years who had experienced a stroke (one or multiple events) and had returned to community living, completed the survey. Associations were examined using correlations, and univariate and multiple linear regression analyses.Results:Regression analysis showed that greater participation, measured using the CIQ, was associated with younger age, female gender, lower self-discrepancy and higher perceived recovery, explaining 69% of the variability in CIQ participation. Further, greater participation on the SISv3 was associated with lower self-discrepancy and higher perceived recovery, explaining 64% of the variability in SISv3 participation.Conclusions:Results indicate that personal factors, particularly self-appraisals like self-concept/self-discrepancy, in combination with perceived recovery may be important in explaining a large portion of variance in post-stroke participation. Specifically, findings highlight the interrelatedness of self-concept change, perceived recovery and post-stroke participation. Further longitudinal research is needed to clarify the directionality of these associations throughout the hospital-to-home transition.
The Reputation of James VI and I Revisited
Authors: Questier Michael Corrie 
Published: December 2022

AbstractThe (in)capacity of the House of Stuart to provide competent royal government, in both Scotland and England, has been a staple topic in the historiography of the British Isles. Despite the increasing volume and sophistication of recent research in this area, the long shadow of past analytical habits of mind still colors modern approaches to the subject. This has been the case with King James VI and I, as with other Stuart sovereigns. Scholarly accounts of the Jacobean period have been affected by a persistent Anglocentricity in this field. Such attitudes have done little for the broader topic of post-Reformation politics and threaten to close several available avenues of research and interpretation. Here it is argued that accounts of Jacobean politics need to be located in their appropriate contexts in order to avoid presentist distortion in future research and publication on this topic and related issues of the period.
Exploring the demography and conservation needs of hawksbill sea turtles Eretmochelys imbricata in north-west Mexico
Authors: Martínez-Estévez Lourdes , Angulo Angulo Abelino , Astorga Mayra Estrella , Becerra Cosme Damián , Leyva Nazario Campaña , Amador Felipe Cuevas , Amador Juan Pablo Cuevas , de la Vega Carvajal Tania , Robledo Anely Fernández , Gaos Alexander R. , Hart Catherine E. , Weaver Amy Hudson , López José Luis , Lucero Jesus , Llamas Israel , Mancini Agnese , Oceguera Karen , Seminoff Jeffrey A. , Tershy Bernie R. , Yañez Ingrid L. , Zavala-Norzagaray Alan , Croll Donald A. 
Published: December 2022

AbstractThe hawksbill sea turtle Eretmochelys imbricata is categorized as Critically Endangered on the IUCN Red List and its population has declined by over 80% in the last century. The Eastern Pacific population is one of the most threatened hawksbill populations globally. Western Mexico is the northern distribution limit for hawksbill sea turtles in the Eastern Pacific and recent research indicates that the Mexican Pacific portion of the population is a separate management unit because of the restricted movements of these turtles. Here we use the most complete database of sighting records in the north-west Pacific of Mexico to identify sites where hawksbill turtles are present. We also develop a conservation index to determine the conservation status of hawksbill turtle sites. Our results demonstrate the importance of this region for juveniles and the relevance of rocky reefs and mangrove estuaries as habitats for hawksbill turtles. We identified 52 sites with records of hawksbill turtles. Most of these sites (71%) are not protected; however, sites with high conservation value included islands and coastal sites along the Baja California peninsula that are established as marine protected areas. Reefs and mangrove estuaries relevant for hawksbill turtles are probably also significant fish nursery areas that are important for local fishing communities, creating opportunities for conservation strategies that combine science, local engagement and policy to benefit both local fishing communities and hawksbill sea turtle conservation.
Exploring “ownership” of Irish traditional dance music: Heritage or property?
Authors: McDonagh Luke 
Published: December 2022

AbstractDance has rarely been accepted as the subject of copyright protection because works of dance and choreography have lacked commodified property-object status in intellectual property law. If dance is “haunted by its own ephemerality” and, thus, rarely embodied as property, then what of dance music? Music composed, performed, and recorded with a dance audience in mind has formed, on many occasions, the subject matter of intellectual property law claims, as the rancorous recent litigation over the nightclub (and online-streaming) hit “Blurred Lines” demonstrates. In this article, I utilize the case study of traditional Irish dance music to explore how traditional music occupies a space somewhat outside the formal legal system, defined by informal social norms such as reciprocity, sharing, and acknowledgment (attribution). I consider how Irish traditional music can be represented as heritage and as property, reflecting on the type of ownership at play in the Irish traditional music community. I observe that Irish traditional dance music provides an example of “heritage as resistance” – a mode of cultural and social practice that continues to thrive as a living tradition, even in the contemporary market-oriented world of the global North.
Estimated incidence and transmission intensity of rubella infection in Zambia pre-vaccine era 2005–2016
Authors: Mazaba Mazyanga L. , Bosomprah Samuel , Cohen Daniel , Monze Mwaka , Siziya Seter 
Published: December 2022

Abstract
The rubella disease burden in Zambia may be under-estimated. Using models, we describe the transmission dynamics, determine the incidence estimates and assess the level of underestimation of the real burden of rubella infection in Zambia during the pre-vaccination period 2005–2016. This study used both the deterministic compartmental model and likelihood-based method using a Bayesian framework to describe the epidemiology of rubella. A total of 1313 cases of rubella were confirmed with the highest annual number of 255 new cases recorded in 2008. However, 2014 recorded the highest monthly median positivity rate of 9.0%. The observed median rubella cases were 5.5. There was a seasonal pattern in the occurrence of laboratory-confirmed rubella, with higher test positivity rates of rubella infection usually recorded in the months of September, October and November. The modelled monthly median incidence of rubella infection among the general population was 76 and 20 among pregnant women. The incidence of rubella among the non-pregnant women was 44. The average effective reproductive number (Rt) between 2005 and 2016 was estimated as 1.2 with the peak of infection occurring in 2016. The measles surveillance system underestimates the observed burden of rubella. A mass vaccination campaign conducted between January and July is recommended.
The predictors of change in reflective parenting therapy: Uncovering the influence of parental reflective functioning and child temperament in predicting the improvement in parent–child relationship and child outcome following DUET group intervention
Authors: Menashe-Grinberg Atara , Atzaba-Poria Naama 
Published: December 2022

AbstractParental reflective functioning (PRF) is the ability of parents to understand their child’s behavior in light of underlying mental processes; it is a core element in the parent–child relationship. RF is also considered crucial for self-regulation for both parents and their children. We investigated the relationship between improvement in PRF after DUET group intervention (a RF-based intervention) and improvement in the parent–child interaction, child RF, and child adjustment, and we examined whether these improvements were distinct for children with different temperamental traits (e.g., effortful control). Eighty-four parents completed the DUET program and were assessed before and after the intervention. PRF was measured using observation (mind-mindedness) and a questionnaire. Statistical analysis included hierarchical regression and moderation of regression analysis. Results showed that improvement in the parent–child interaction, child RF, and child behavioral problems were related to improvement in PRF. Furthermore, we found that child temperament acted as a moderator in the link between PRF and child RF, supporting a vantage sensitivity model, meaning that it was the more sensitive children who benefitted the most as a result of the positive change in their parents’ RF. Clinical and future directions of this study are discussed.
Prevalence, correlates and common conditions associated with adolescent dietary supplement use: a cross-sectional survey in Bangladesh
Authors: Amin Md. Bony , Aktarujjaman Md. , Meem Amatul Elah , Hossain Ekhtear , Islam Md. Nazrul , Roy Nitai 
Published: December 2022

AbstractObjective:There is a broad spectrum of dietary supplements (DS) and their accessibility worldwide. However, little is known about the prevalence of DS use among Bangladeshi adolescents. This study estimates the prevalence, correlates and common conditions related to DS use.Design:A cross-sectional, convenient sampling strategy was adopted using an interviewer-administered, structured questionnaire.Setting:Kurigram and Patuakhali districts of Bangladesh.Participants:702 adolescents aged 10–19 years.Results:The overall prevalence of DS use was 83 %. The majority of participants (93·4 %) agreed that DS were good for health, and 28·3 % reported general health and well-being as the reason for using DS. The most frequently used supplements were multivitamins (38·6 %) and Ca (37 %). DS use was more common among adolescents who had ≤5 siblings, good health status, no chronic diseases, a positive impression that DS are good for health and who had the tendency to encourage DS to others. DS use was also higher among those who received DS information from healthcare providers, professional literature, friends, family and relatives.Conclusions:The prevalence of DS use is relatively higher among Bangladeshi adolescents compared to Bangladeshi adults and adolescents from other countries, highlighting the inclination towards DS use. Guidelines for safe DS use for adolescents are warranted to control DS use and prevent adverse effects.
A Mechanistic Sea Spray Generation Function Based on the Sea State and the Physics of Bubble Bursting
Authors: Deike L. , Reichl B. G. , Paulot F. 
Published: December 2022

AbstractBubbles bursting at the ocean surface are an important source of ocean‐spray aerosol, with implications on radiative and cloud processes. Yet, very large uncertainties exist on the role of key physical controlling parameters, including wind speed, sea state and water temperature. We propose a mechanistic sea spray generation function that is based on the physics of bubble bursting. The number and mean droplet radius of jet and film drops is described by scaling laws derived from individual bubble bursting laboratory and numerical experiments, as a function of the bubble radius and the water physico‐chemical properties (viscosity, density and surface tension, all functions of temperature), with drops radii at production from 0.1 to 500 µm. Next, we integrate over the bubble size distribution entrained by breaking waves. Finally, the sea spray generation function is obtained by considering the volume flux of entrained bubbles due to breaking waves in the field constrained by the third moment of the breaking distribution (akin to the whitecap coverage). This mechanistic approach naturally integrates the role of wind and waves via the breaking distribution and entrained air flux, and a sensitivity to temperature via individual bubble bursting mechanisms. The resulting sea spray generation function has not been tuned or adjusted to match any existing data sets, in terms of magnitude of sea salt emissions and recently observed temperature dependencies. The remarkable coherence between the model and observations of sea salt emissions therefore strongly supports the mechanistic approach and the resulting sea spray generation function.
Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury
Authors: Li Hongyu , Leung Joseph C. K. , Yiu Wai Han , Chan Loretta Y. Y. , Li Bin , Lok Sarah W. Y. , Xue Rui , Zou Yixin , Lai Kar Neng , Tang Sydney C. W. 
Published: December 2022

AbstractMitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction in chronic kidney fibrosis, little is known of the influence of β-catenin on mitochondrial function in AKI. To decipher this interaction, we generated an inducible mouse model of tubule-specific β-catenin overexpression (TubCat), and a model of tubule-specific β-catenin depletion (TubcatKO), and induced septic AKI in these mice with lipopolysaccharide (LPS) and aseptic AKI with bilateral ischemia-reperfusion. In both AKI models, tubular β-catenin stabilization in TubCat animals significantly reduced BUN/serum creatinine, tubular damage (NGAL-positive tubules), apoptosis (TUNEL-positive cells) and necroptosis (phosphorylation of MLKL and RIP3) through activating AKT phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased PGC-1α and NRF1) and restored mitochondrial mass (increased TIM23) to re-establish mitochondrial homeostasis (increased fusion markers OPA1, MFN2, and decreased fission protein DRP1) through the FOXO3/PGC-1α signaling cascade. Conversely, kidney function loss and histological damage, tubular cell death, and mitochondrial dysfunction were all aggravated in TubCatKO mice. Mechanistically, β-catenin transfection maintained mitochondrial mass and activated PGC-1α via FOXO3 in LPS-exposed HK-2 cells. Collectively, these findings provide evidence that tubular β-catenin mitigates cell death and restores mitochondrial homeostasis in AKI through the common mechanisms associated with activation of AKT/p53 and FOXO3/PGC-1α signaling pathways.
IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation
Authors: Zhou Tian , Yang Ziqi , Ni Biyan , Zhou Hong , Xu Huiyi , Lin Xiaojing , Li Yingmin , Liu Chunqiao , Ju Rong , Ge Jian , He Chang , Liu Xialin 
Published: December 2022

AbstractRetinal degeneration is a kind of neurodegeneration characterized by progressive neuronal death and dysfunction of retinal pigment epithelium (RPE) cells, leading to permanent visual impairment. It still lacks effective therapeutic options and new drugs are highly warranted. In this study, we found the expression of IL-4, a critical regulator of immunity, was reduced in both patients and mouse models. Importantly, exogenous intravitreal IL-4 application could exert a novel neuroprotective effect, characterized by well-preserved RPE layer and neuroretinal structure, as well as amplified wave-amplitudes in ERG. The RNA-seq analysis revealed that IL-4 treatment suppressed the essential oxidative and pro-inflammatory pathways in the degenerative retina. Particularly, IL-4 upregulated the IL-4Rα on RPE cells and induced a reparative phenotype via the activation of Nrf2 both in vitro and in vivo. Furthermore, the Nrf2-/- mice displayed no recovery in response to IL-4 application, highlighting a significant role of Nrf2 in IL-4-mediated protection. Our data provides evidence that IL-4 protects against retinal neurodegeneration by its antioxidant and anti-inflammatory property through IL-4Rα upregulation and Nrf2 activation in RPE cells. The IL-4/IL-4Rα-Nrf2 axis maybe the potential targets for the development of novel therapies for neurodegenerative diseases.
Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo
Authors: Bachmann Magdalena , Rossa Andrea , Varanita Tatiana , Fioretti Bernard , Biasutto Lucia , Milenkovic Stefan , Checchetto Vanessa , Peruzzo Roberta , Ahmad Syed A. , Patel Sameer H. , Lukowski Robert , Edwards Michael J. , Ceccarelli Matteo , Gulbins Erich , Zoratti Mario , Mattarei Andrea , Szabo Ildiko 
Published: December 2022

AbstractIon channels are non-conventional, druggable oncological targets. The intermediate-conductance calcium-dependent potassium channel (KCa3.1) is highly expressed in the plasma membrane and in the inner mitochondrial membrane (mitoKCa3.1) of various cancer cell lines. The role mitoKCa3.1 plays in cancer cells is still undefined. Here we report the synthesis and characterization of two mitochondria-targeted novel derivatives of a high-affinity KCa3.1 antagonist, TRAM-34, which retain the ability to block channel activity. The effects of these drugs were tested in melanoma, pancreatic ductal adenocarcinoma and breast cancer lines, as well as in vivo in two orthotopic models. We show that the mitochondria-targeted TRAM-34 derivatives induce release of mitochondrial reactive oxygen species, rapid depolarization of the mitochondrial membrane, fragmentation of the mitochondrial network. They trigger cancer cell death with an EC50in the µM range, depending on channel expression. In contrast, inhibition of the plasma membrane KCa3.1 by membrane-impermeant Maurotoxin is without effect, indicating a specific role of mitoKCa3.1 in determining cell fate. At sub-lethal concentrations, pharmacological targeting of mitoKCa3.1 significantly reduced cancer cell migration by enhancing production of mitochondrial reactive oxygen species and nuclear factor-κB (NF-κB) activation, and by downregulating expression of Bcl-2 Nineteen kD-Interacting Protein (BNIP-3) and of Rho GTPase CDC-42. This signaling cascade finally leads to cytoskeletal reorganization and impaired migration. Overexpression of BNIP-3 or pharmacological modulation of NF-κB and CDC-42 prevented the migration-reducing effect of mitoTRAM-34. In orthotopic models of melanoma and pancreatic ductal adenocarcinoma, the tumors at sacrifice were 60% smaller in treated versus untreated animals. Metastasis of melanoma cells to lymph nodes was also drastically reduced. No signs of toxicity were observed. In summary, our results identify mitochondrial KCa3.1 as an unexpected player in cancer cell migration and show that its pharmacological targeting is efficient against both tumor growth and metastatic spread in vivo.