bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing treatment decision‐making for cancer patients in low‐ and middle‐income countries: A scoping review
Authors: Salek Marta , Silverstein Allison , Tilly Alyssa , Gassant Pascale Yola , Gunasekera Sanjeeva , Hordofa Diriba Fufa , Hesson Donna , Duffy Caitlyn , Malik Nauman , McNeil Michael , Force Lisa M. , Bhakta Nickhill , Rodin Danielle , Kaye Erica C. 
Published: August 2023

AbstractPurposeIn this scoping review, we evaluated existing literature related to factors influencing treatment decision‐making for patients diagnosed with cancer in low‐ and middle‐income countries, noting factors that influence decisions to pursue treatment with curative versus non‐curative intent. We identified an existing framework for adult cancer developed in a high‐income country (HIC) context and described similar and novel factors relevant to low‐and middle‐income country settings.MethodsWe used scoping review methodology to identify and synthesize existing literature on factors influencing decision‐making for pediatric and adult cancer in these settings. Articles were identified through an advanced Boolean search across six databases, inclusive of all article types from inception through July 2022.ResultsSeventy‐nine articles were identified from 22 countries across six regions, primarily reporting the experiences of lower‐middle and upper‐middle‐income countries. Included articles largely represented original research (54%), adult cancer populations (61%), and studied patients as the targeted population (51%). More than a quarter of articles focused exclusively on breast cancer (28%). Approximately 30% described factors that influenced decisions to choose between therapies with curative versus non‐curative intent. Of 56 reported factors, 22 novel factors were identified. Socioeconomic status, reimbursement policies/cost of treatment, and treatment and supportive care were the most commonly described factors.ConclusionsThis scoping review expanded upon previously described factors that influence cancer treatment decision‐making in HICs, broadening knowledge to include perspectives of low‐ and middle‐income countries. While global commonalities exist, certain variables influence treatment choices differently or uniquely in different settings. Treatment regimens should further be tailored to local environments with consideration of contextual factors and accessible resources that often impact decision‐making.
Fulvestrant with or without anti‐HER2 therapy in patients in a postmenopausal hormonal state and with ER‐positive HER2‐positive advanced or metastatic breast cancer: A subgroup analysis of data from the Safari study (JBCRG‐C06)
Authors: Masuyama Misato , Masuda Norikazu , Kawaguchi Hidetoshi , Yamamoto Yutaka , Saji Shigehira , Nakayama Takahiro , Aogi Kenjiro , Anan Keisei , Ohtani Shoichiro , Sato Nobuaki , Takano Toshimi , Tokunaga Eriko , Nakamura Seigo , Hasegawa Yoshie , Hattori Masaya , Fujisawa Tomomi , Morita Satoshi , Yamaguchi Miki , Yamashita Toshinari , Yotsumoto Daisuke , Toi Masakazu , Ohno Shinji 
Published: August 2023

AbstractBackgroundThe role of endocrine therapy in the treatment of patients in a postmenopausal hormonal state and with estrogen receptor (ER)‐positive, human epidermal growth factor receptor 2 (HER2)‐positive advanced or metastatic breast cancer (AMBC) is unclear.MethodsWe analyzed the data from 94 patients with ER‐positive HER2‐positive AMBC enrolled in the Safari study (UMIN000015168), a retrospective cohort study of 1072 ER‐positive AMBC patients in a postmenopausal hormonal state who received fulvestrant 500 mg (F500): (1) to compare time to treatment failure (TTF) and overall survival (OS) by treatment group, and TTF by treatment line; (2) in patients who received endocrine therapy (including F500) or anti‐HER2 therapy as initial systemic therapy before chemotherapy, to investigate relations between TTF for the first‐line therapy or time to chemotherapy (TTC) and OS; (3) to investigate factors associated with OS.ResultsThe TTF was longer in the patients treated with F500 as first‐ or second‐line therapy (n = 20) than in those who received later‐line F500 therapy (n = 74) (6.6 vs. 3.7 months; HR, 1.98; p = 0.014). In the 59 patients who received endocrine therapy or anti‐HER2 therapy as initial systemic therapy before chemotherapy, those with TTC ≥3 years had longer median OS than those with TTC <3 years (10.5 vs. 5.9 years; HR, 0.32; p = 0.001). Longer TTC was associated with prolonged OS.ConclusionsIn patients with ER‐positive HER2‐positive AMBC enrolled in the Safari study, TTF was longer in patients who received F500 as first‐ or second‐line therapy. In patients who received chemotherapy‐free initial systemic therapy, the prolonged OS in those with TTC ≥3 years suggests that this value may be a helpful cut‐off for indicating clinical outcomes.
Comparing online group therapy based on emotional schema therapy with transdiagnostic therapy in improving distress tolerance and cognitive emotion regulation among university students with adjustment disorders due to romantic break‐ups
Authors: Ariana Kia Elmira , Rahimi Changiz , Mohammadi Nurallah 
Published: August 2023

AbstractThis study aimed to compare the effectiveness of online group therapy based on emotional schema therapy with that of transdiagnostic therapy in improving distress tolerance and cognitive emotion regulation among university students with adjustment disorders due to romantic break‐ups. The statistical population included all students who experienced a romantic break‐up in Iran in 2020, aged 18–38 years. Due to COVID‐19 pandemic restrictions, participants were selected online. After filling in initial forms, diagnostic interviews were conducted through purposive sampling. A group was then randomly selected and divided into three groups: the first experimental group (transdiagnostic group therapy) included 15 participants; the second experimental group (emotional schema therapy) consisted of 15 participants; and the third group was the control group with 15 participants. The experimental groups received ten 90‐min group therapy sessions. Participants completed the Distress Tolerance Questionnaire and the Cognitive Emotion Regulation Questionnaire at pretest, post‐test and 1‐month follow‐up stages. According to the results of repeated measures ANOVA, there were significant differences between the experimental and control groups (p < 0.05) in the post‐test scores of distress tolerance and cognitive emotion regulation strategies. However, there were no significant differences between the two experimental groups. The results indicated that both internet‐based transdiagnostic group therapy and emotional schema therapy were effective interventions in mitigating symptoms of adjustment disorders due to romantic break‐ups among university students. This highlights the potential of online group therapy as a viable option for students experiencing such disorders, particularly during pandemic‐related restrictions.
Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks
Authors: Breen Meghan E. , Joy Stephen T. , Baruti Omari J. , Beyersdorf Matthew S. , Henley Madeleine J. , De Salle Samantha N. , Ycas Peter D. , Croskey Ayza , Cierpicki Tomasz , Pomerantz William C. K. , Mapp Anna K. 
Published: August 2023

AbstractNatural products are often uniquely suited to modulate protein‐protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid allosterically blocks the CBP/p300 KIX PPI network and displays excellent selectivity over related GACKIX motifs. It does so via a strong interaction (KD 1 μM) with a non‐canonical binding site containing a structurally dynamic loop in CBP/p300 KIX. Garcinolic acid engages full‐length CBP in the context of the proteome and in doing so effectively inhibits KIX‐dependent transcription in a leukemia model. As the most potent small‐molecule KIX inhibitor yet reported, garcinolic acid represents an important step forward in the therapeutic targeting of CBP/p300.
Stent expansion in calcified coronary chronic total occlusions: The impact of different stent platforms
Authors: Scarparo Paola , Schermers Thom , Improta Riccardo , Kardys Isabella , Wilschut Jeroen , Daemen Joost , Nuis Rutger‐Jan , Den Dekker Wijnand K. , Van Mieghem Nicolas M. , Diletti Roberto 
Published: August 2023

AbstractObjectivesTo evaluate the stent expansion of the durable‐polymer Zotarolimus‐eluting stent (dp‐ZES), the durable‐polymer Everolimus‐eluting stent (dp‐EES), and the bioabsorbable‐polymer Sirolimus‐eluting stent (bp‐SES) in calcified coronary chronic total occlusions (CTO).BackgroundThe newer generation stents with ultrathin struts might raise concerns regarding reduced radial strength and higher stent recoil (SR) when implanted in calcified CTOs.MethodsBetween January 2017 and June 2021 consecutive patients with CTO undergoing percutaneous coronary intervention with dp‐ZES, dp‐EES, or bp‐SES were evaluated. The analysis was performed in calcific and in noncalcific CTOs. Quantitative coronary angiography analysis was used to assess diameter stenosis (DS), absolute and relative SR, absolute and relative focal SR, absolute and relative balloon deficit (BD), and absolute and relative focal BD. The primary endpoint was DS.ResultsA total of 213 CTOs were evaluated, 115 calcific CTOs (dp‐ZES:25, dp‐EES:29, bp‐SES:61) and 98 non‐calcific CTOs (dp‐ZES:41, dp‐EES:11, bp‐SES:46). In calcific CTOs, residual DS was lower in dp‐ZES than in dp‐EES and bp‐SES (−1.00% [−6.50–6.50] vs. 13.00% [7.0–19.00] vs. 15.00% [5.00–20.00]; p < 0.001). Dp‐ZES was also an independent predictor of residual DS ≤ 10% (OR 11.34, 95% CI 2.6–49.43, p = 0.001). Absolute and relative focal SR and absolute and relative SR were similar between dp‐ZES, dp‐EES, and bp‐SES (p = 0.913, p = 0.890, p = 0.518, p = 0.426, respectively). In noncalcified CTOs, the residual DS was similar in the three groups (p = 0.340). High relative focal SR was less frequent in dp‐ZES than in dp‐EES and in bp‐SES (19.5% vs. 54.5% vs. 37.0%; p < 0.048).ConclusionsThe three stent platforms demonstrated an overall low residual DS when implanted in CTOs. However, dp‐ZES was associated with the lowest residual DS and identified as independent predictor of residual DS ≤ 10% in patients with calcific CTOs. Dp‐ZES was associated with a lower incidence of high relative focal stent recoil, in noncalcific CTOs. Balloon deficit might be considerate as a surrogate for stent expansion in calcified CTOs.
Tunable Fluorescence and Morphology of Aggregates Built from a Mechanically Bonded Amphiphilic Bistable [2]Rotaxane
Authors: Shi Jun‐Tao , Chen Xian‐Hui , Peng Yuan‐Yuan , Wang Gui‐Ping , Du Guang‐Yan , Li Quan 
Published: August 2023

AbstractAdvanced Organic Chemical Materials Co‐constructed Mechanically bonded amphiphiles (MBAs), also known as mechanically interlocked molecules (MIMs), have emerged as an important kind of functional building block for the construction of artificial molecular machines and soft materials. Herein, a novel MBA, i. e., bistable [2]rotaxane H2 was designed and synthesized. In the solution state, H2 demonstrated pH and metal ion‐responsive emissions due to the presence of a distance‐dependent photoinduced electron transfer (PET) process and the fluorescence resonance energy transfer (FRET) process, respectively. Importantly, the amphiphilic feature of H2 has endowed it with unique self‐assembly capability, and nanospheres were obtained in a mixed H2O/CH3CN solvent. Moreover, the morphology of H2 aggregates can be tuned from nanospheres to vesicles due to the pH‐controlled shuttling motion‐induced alternation of H2 amphiphilicity. Interestingly, larger spheres with novel pearl‐chain‐like structures from H2 were observed after adding stoichiometric Zn2+. In particular, H2 shows pH‐responsive emissions in its aggregation state, allowing the visualization of the shuttling movement by just naked eyes. It is assumed that the well‐designed [2]rotaxane, and particularly the proposed concept of MBA shown here, will further enrich the families of MIMs, offering prospects for synthesizing more MIMs with novel assembly capabilities and bottom‐up building dynamic smart materials with unprecedented functions.
Advanced NMR Cryoporometry
Authors: Enninful Henry R. N. B. , Enke Dirk , Valiullin Rustem 
Published: August 2023

AbstractAccurate structural characterization of mesoporous solids is of importance for potential applications and for better understanding of properties of natural porous materials. Among different characterization techniques, thermoporometry has several beneficial features, such as applicability to wetted and soft materials. In this review, we discuss recent advancements concerning nuclear magnetic resonance cryoporometry allowing for a notable improvement of the accuracy of this method.
Design and simulation study on the heating performance of mesh heating elements
Authors: Xiao Weiqiang , Li Te , Wang Huawen , Wang Jun , Xia Qian , Teng Ruyu , Han Yufeng , Zhan Wangcheng , Zhou Guojun 
Published: August 2023

AbstractTo achieve uniform heating of heat‐not‐burn cigarettes, the ANSYS Workbench was used to verify the calculation rule of the resistance value of the mesh heating element. To provide a theoretical basis for improving the design of mesh heating elements, the effect of rounded corners on the resistance value and that of key parameters such as the number of mesh heat emitters in series and parallel, mesh density, and heating power on the heating uniformity were investigated. The deviation of all calculation results is less than 2.4%, indicating that the total resistance value of the mesh heating element conforms to the calculation rule of the series and parallel connections of single‐module resistors. The heating power increases by 3.2%, which has a relatively small impact on the overall heating element when a rounded corner with a radius equal to the line width is added to the corner of the heating element. The area of the heating body increases when increasing the number of series connections and reducing the number of parallel connections, which is conducive to uniform heating. While maintaining the ratio of the number of series connections to the number of parallel connections constant, reducing the module size will not change the area of the mesh heating element, but it will improve the temperature uniformity. Under different power conditions, the heating uniformity of the same heating element does not change.
A modelling approach to investigate the performance of slurry bubble column reactors implementingFischer–Tropschsynthesis
Authors: Mokhtari Mojtaba , Chaouki Jamal 
Published: August 2023

AbstractA reliable estimation of the reactor performance is a crucial aspect of slurry bubble column reactor design. Hydrodynamics, mass transfer, and reaction rate are the main parameters influencing the overall performance. A new hydrodynamic model was adopted in this study to properly predict the effect of solids loading, particle size, pressure, and temperature on the gas holdup, bubble size distribution, and mass transfer coefficient. The reactor was divided into small cells with individual hydrodynamic parameters. The results were compared with the experimental data and showed that the model can acceptably predict the hydrodynamic and mass transfer parameters in various process situations. A parametric study was accomplished to understand the effect of catalyst loading, superficial gas velocity, H2/CO ratio,L/Dratio, pressure, temperature, and catalyst attrition on the conversion rate, catalyst productivity, and space–time yield. A cobalt/silica catalyst was adopted in this study. Based on the obtained results, the syngas conversion increases by catalyst loading,L/D, and temperature, while it decreases byUgand pressure. The H2/CO ratio results in a maximum conversion somewhere between 2 and 2.5. Three different scenarios were determined to study the effect of catalyst attrition on the reactor performance. The results show that the attrition decreases the syngas conversion due to the decrease in the catalyst size and the catalyst loss. Also, the performance remains constant if a sufficient amount of fresh catalyst is added to the system continuously.
The infrastructure of electrophysiology centers impacts the management of cardiac tamponade—Results from a national survey
Authors: Rottner Laura , Reubold Stefan , Schönhofer Sophie , Reißmann Bruno , Ouyang Feifan , Obergassel Julius , My Ilaria , Moser Fabian , Wenzel Jan‐Per , Lemoine Marc , Steven Daniel , Sommer Philipp , Kirchhof Paulus , Rillig Andreas , Metzner Andreas 
Published: August 2023

AbstractBackgroundAlthough electrophysiological (EP) centers have institutional standards, evidence on management of cardiac tamponade is lacking.Aim and MethodsA physician‐based survey was conducted by sending out questionnaires to all hospitals in Germany performing EP procedures. To evaluate the infrastructure of EP centers and the impact of center volume and onsite cardiac surgery on the management of cardiac tamponade, the results of the survey were analyzed for low‐volume (0–250 procedures per year), mid‐volume (250–500 procedures), and high‐volume (>500 procedures) centers, as well as for centers with and without onsite cardiac surgery.ResultsA total of 341 centers were identified and 189/341 (55%) returned data sets were analyzed. Most types of EP procedures are performed across all kinds of centers. Ablation of ventricular tachycardia (VT) is concentrated in higher volume centers and in centers with onsite cardiac surgery. None of the participating low‐volume centers and only 13% of centers without onsite cardiac surgery responded to performing epicardial VT ablation. Irrespective of center volume and onsite cardiac surgery, neither body mass index nor age was reported to be an exclusion criterion for ablation procedures. Higher volume centers and centers with onsite cardiac surgery more often have dedicated EP laboratories and EP‐nursing teams. Also, differences regarding periprocedural safety precautions and management of cardiac tamponade were found for low‐, mid‐, and high‐volume centers, as well as for centers with and without onsite cardiac surgery.ConclusionWhile center volume and onsite cardiac surgery do not impact patient selection, there are differences in ablation spectrum, infrastructure, periprocedural safety precautions, and treatment of tamponade.
Construction of Crystalline Porous Frameworks (COF/MOF) with Multi‐components or by Multi‐reactions
Authors: Teong Siew Ping , Zhang Yugen 
Published: August 2023

AbstractCovalent organic frameworks (COFs) and metal organic frameworks (MOFs) are crystalline porous materials with ordered framework structures. To create diverse framework structures, linkers with different geometries and sizes have been developed over the past decades. However, for more advanced applications, there is a need for continuous pore size control and property development. Researchers are exploring new synthesis methods, building blocks, and processing/fabrication protocols to meet these demands. Multi‐component or multiple ligands synthesis has been widely used in the construction of MOF structures, and this synthetic strategy has recently been adopted for COF synthesis and extended to versatile linker designing strategies. This review focuses on the recent development of the multi‐component or multi‐reaction strategy for COF synthesis, its application in new MOF synthetic strategies, and ligand development.
Learning multi‐organ and tumor segmentation from partially labeled datasets by a conditional dynamic attention network
Authors: Li Lei , Lian Sheng , Lin Dazhen , Luo Zhiming , Wang Beizhan , Li Shaozi 
Published: August 2023

SummaryMulti‐organ segmentation is a critical prerequisite for many clinical applications. Deep learning‐based approaches have recently achieved promising results on this task. However, they heavily rely on massive data with multi‐organ annotated, which is labor‐ and expert‐intensive and thus difficult to obtain. In contrast, single‐organ datasets are easier to acquire, and many well‐annotated ones are publicly available. It leads to the partially labeled issue: How to learn a unified multi‐organ segmentation model from several single‐organ datasets? Pseudo‐label‐based methods and conditional information‐based methods make up the majority of existing solutions, where the former largely depends on the accuracy of pseudo‐labels, and the latter has a limited capacity for task‐related features. In this paper, we propose the Conditional Dynamic Attention Network (CDANet). Our approach is designed with two key components: (1) multisource parameter generator, fusing the conditional and multiscale information to better distinguish among different tasks, and (2) dynamic attention module, promoting more attention to task‐related features. We have conducted extensive experiments on seven partially labeled challenging datasets. The results show that our method achieved competitive results compared with the advanced approaches, with an average Dice score of 75.08%. Additionally, the Hausdorff Distance is 26.31, which is a competitive result.
Metal‐Organic Framework Membrane Hybridized with Graphitic Materials for Gas Separation
Authors: Choi Eunji , Kwon Ohchan , Hoo Lee Choong , Woo Kim Dae 
Published: August 2023

AbstractMetal‐organic frameworks (MOFs) are an exceptional class of crystalline materials that have been extensively used to fabricate membranes for various applications such as gas separation, ion transport, and desalination due to their well‐defined pore structure, chemical features, and simple synthesis process. The incorporation of graphitic carbon materials in MOFs has garnered significant attention as it can provide abundant nucleation sites and modulate gas transport by influencing the orientation or rigidity of MOF crystals without changing their porous structure. This review insights of previous studies utilizing graphene, graphene oxide, carbon nanotubes, and graphene nanoribbons for MOF‐based gas separation membranes, particularly focusing on polycrystalline MOF membrane hybridization with graphitic materials. We also briefly discuss the use of carbon/MOF hybrid materials for preparing mixed matrix membranes.
A novel control method for enhanced performance of single‐phase matrix converters
Authors: Al‐Dori Osamah , Vural Ahmet Mete 
Published: August 2023

AbstractThe conventional topology of direct single‐to‐single‐phase matrix converter (SSMC) is widely adopted in industrial and power system‐related applications owing to its desired features. Current control methods in the literature either limit the voltage transfer ratio (VTR) or prohibit their utilization to drive inductive (RL) loads. In this study, we propose a novel control method that overcomes these limitations by enabling the SSMC to achieve relatively high VTRs while driving RL loads with negligible output voltage spikes and without current commutation problems. Further, the proposed control method improves the overall performance by reducing output voltage and source input current total harmonic distortion (THD) and offering soft‐switching at the commutation instances. The rigidity of the proposed control method over the counterpart methods in the literature is verified through simulation and experimental case studies over a wide range of synthesized output frequencies and modulation indexes. A 530‐W laboratory prototype is built for the experimental study. Results demonstrated the ability of the proposed method in enabling the SSMC to drive an RL load without current commutation issues and with mitigated output voltage spikes while achieving relatively high VTRs and suppressing the output voltage and source input current THD.