bluuebunny/crossref_metadata_2025_split huggingface dataset:
KESIAPAN ORANG TUA SISWA SEKOLAH DASAR DI KOTA SEMARANG DALAM MEMPERSIAPKAN PERTEMUAN TATAP MUKA DI ERA ADAPTASI KEBIASAAN BARU
Authors: Wulandari, SKM, M.Kes Fitria , Aprianti Aprianti , Laksana Dian Puspitaningtyas 
Published: May 2023

Anak sekolah cenderung lebih rentan dengan penularan Covid-19, data WHO 2020,penderita yang terjangkit Covid-19 mengalami penyakit tanpa komplikasi atau ringan (81%), pasien parah dengan bantuan oksigen (14%) dan perlu masuk unit perawatan intensif. (5%). Di Kota Semarang dengan total penderita 25 anak dengan status pasien dalam pemantauan. Penelitian ini bertujuan untuk mengetahui kesiapan orang tua dalam mempersiapkan pertemuan tatap muka di kelas, Penelitian ini merupakan penelitian observasional dengan metode cross sectional dimana pengambilan data dilakukan dalam satu waktu. Penelitian ini menggunakan kuesioner berupa angket sebagai alat bantu dalam pengambilan data. Hasil : responden dalam penelitian terdiri dari perempuan yaitu sebesar 86,8%, sedangkan sisanya adalah laki-laki yaitu sebesar 13,2%. Sebanyak 86,3% reponden mendampingi anak belajar di rumah, sebanyak 20% responden yang tidak mengizinkan anaknya untuk mengikuti belajar tatap muka memiliki tingkat pengetahuan yang kurang. Uji statisik nilai p-value sebesar 0,839 yang artinya tidak ada hubungan yang signifikan antara tingkat pengetahuan dengan izin untuk mengikuti belajar tatap muka, nilai p-value sebesar 0,371 yang artinya tidak ada hubungan yang signifikan antara perilaku dengan izin untuk mengikuti belajar tatap muka, serta nilai p-value sebesar 0,755yang artinya tidak ada hubungan yang signifikan antara literasi kesehatan dengan izin untuk mengikuti belajar tatap muka, Perlu dilakukan peneltian lebih lanjut terhadap guru dan sekolah dalam memepersiapakan pertemuan tatap muka di kelas. serta di butuhkan sebuah system yang dapat di gunakan untuk memantau pelaksanaan protocol kesehatan selama berada di sekolah, oleh guru maupun siswa
Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan
Authors: Xu Li , Ren Zhanying , Li Guolin , Xu Danni , Miao Jiaqian , Ju Jingxuan , Mo Xuan , Wang Xianghui , Deng Hongping , Xu Min 
Published: May 2023

Commercial gadolinium (Gd)-based contrast agents (GBCAs) play important role in clinical diagnostic of hepatocellular carcinoma, but their diagnostic efficacy remained improved. As small molecules, the imaging contrast and window of GBCAs is limited by low liver targeting and retention. Herein, we developed a liver-targeting gadolinium (Ⅲ) chelated macromolecular MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan, namely, CS-Ga-(Gd-DTPA)n, to improve hepatocyte uptake and liver retention. Compared to Gd-DTPA and non-specific macromolecular agent CS-(Gd-DTPA)n, CS-Ga-(Gd-DTPA)n showed higher hepatocyte uptake, excellent cell and blood biocompatibility in vitro. Furthermore, CS-Ga-(Gd-DTPA)n also exhibited higher relaxivity in vitro, prolonged retention and better T1-weighted signal enhancement in liver. At 10 days post-injection of CS-Ga-(Gd-DTPA)n at a dose of 0.03 mM Gd/Kg, Gd had a little accumulation in liver with no liver function damage. The good performance of CS-Ga-(Gd-DTPA)n gives great confidence in developing liver-specifc MRI contrast agents for clinical translation.
Loop-mediated isothermal amplification (LAMP)/Cas12a assay for detection of Ralstonia solanacearum in tomato
Authors: Fan Zhiyu , Mei Yuxia , Xing Jiawei , Chen Tian , Hu Di , Liu Hui , Li Yingjun , Liu Derui , Liu Zufeng , Liang Yunxiang 
Published: May 2023

Introduction: Bacterial wilt (BW) caused by the aerobic, Gram-negative pathogenic species Ralstonia solanacearum (RS) is a major disease impacting commercial agriculture worldwide. Asian phylotype I of RS is the cause of tomato bacterial wilt, which has caused severe economic losses in southern China for many years. An urgent priority in control of bacterial wilt is development of rapid, sensitive, effective methods for detection of RS.Methods: We describe here a novel RS detection assay based on combination of loop-mediated isothermal amplification (LAMP) and CRISPR/Cas12a. crRNA1, with high trans-cleavage activity targeting hrpB gene, was selected out of four candidate crRNAs. Two visual detection techniques, involving naked-eye observation of fluorescence and lateral flow strips, were tested and displayed high sensitivity and strong specificity.Results and Discussion: The LAMP/Cas12a assay accurately detected RS phylotype Ⅰ in 14 test strains, and showed low detection limit (2.0 × 100 copies). RS in tomato stem tissue and soil samples from two field sites with suspected BW infection was identified accurately, suggesting potential application of LAMP/Cas12a assay as point-of-care test (POCT). The overall detection process took less than 2 h and did not require professional lab equipment. Our findings, taken together, indicate that LAMP/Cas12a assay can be developed as an effective, inexpensive technique for field detection and monitoring of RS.
Trends in surgical aortic valve replacement in pre- and post-transcatheter aortic valve replacement eras at a structural heart center
Authors: Norton Elizabeth L. , Ward Alison F. , Tully Andy , Leshnower Bradley G. , Guyton Robert A. , Paone Gaetano , Keeling William B. , Miller Jeffrey S. , Halkos Michael E. , Grubb Kendra J. 
Published: May 2023

BackgroundThe advent of transcatheter aortic valve replacement (TAVR) has directly impacted the lifelong management of patients with aortic valve disease. The U.S. Food and Drug Administration has approved TAVR for all surgical risk: prohibitive (2011), high (2012), intermediate (2016), and low (2019). Since then, TAVR volumes are increasing and surgical aortic valve replacements (SAVR) are decreasing. This study sought to evaluate trends in isolated SAVR in the pre- and post-TAVR eras.MethodsFrom January 2000 to June 2020, 3,861 isolated SAVRs were performed at a single academic quaternary care institution which participated in the early trials of TAVR beginning in 2007. A formal structural heart center was established in 2012 when TAVR became commercially available. Patients were divided into the pre-TAVR era (2000–2011, n = 2,426) and post-TAVR era (2012–2020, n = 1,435). Data from the institutional Society of Thoracic Surgeons National Database was analyzed.ResultsThe median age was 66 years, similar between groups. The post-TAVR group had a statistically higher rate of diabetes, hypertension, dyslipidemia, heart failure, more reoperative SAVR, and lower STS Predicted Risk of Mortality (PROM) (2.0% vs. 2.5%, p &lt; 0.0001). There were more urgent/emergent/salvage SAVRs (38% vs. 24%) and fewer elective SAVRs (63% vs. 76%), (p &lt; 0.0001) in the post-TAVR group. More bioprosthetic valves were implanted in the post-TAVR group (85% vs. 74%, p &lt; 0.0001). Larger aortic valves were implanted (25 vs. 23 mm, p &lt; 0.0001) and more annular enlargements were performed (5.9% vs. 1.6%, p &lt; 0.0001) in the post-TAVR era. Postoperatively, the post-TAVR group had less blood product transfusion (49% vs. 58%, p &lt; 0.0001), renal failure (1.4% vs. 4.3%, p &lt; 0.0001), pneumonia (2.3% vs. 3.8%, p = 0.01), shorter lengths of stay, and lower in-hospital mortality (1.5% vs. 3.3%, p = 0.0007).ConclusionThe approval of TAVR changed the landscape of aortic valve disease management. At a quaternary academic cardiac surgery center with a well-established structural heart program, patients undergoing isolated SAVR in the post-TAVR era had lower STS PROM, more implantation of bioprosthetic valves, utilization of larger valves, annular enlargement, and lower in-hospital mortality. Isolated SAVR continues to be performed in the TAVR era with excellent outcomes. SAVR remains an essential tool in the lifetime management of aortic valve disease.
Implantable cardioverter defibrillator for primary prevention in patients with non-ischemic cardiomyopathy in the era of novel therapeutic agents- meta-analysis
Authors: Kolben Yotam , Hirsh Raccah Bruria , Koev Ivelin , Luria David , Amir Offer , Biton Yitschak 
Published: May 2023

BackgroundEvidence regarding the mortality benefit of implantable cardioverter defibrillator (ICD) non-ischemic dilated cardiomyopathy (NIDCM) is inconsistent. The most recent randomized study, the DANISH trial, did not find improved outcomes with ICD. However, based on previous studies and meta-analyses, current guidelines still highly recommend ICD implantation in NIDCM patients. The introduction of novel medications for heart failure improved the clinical outcome dramatically. We aimed in this study to evaluate the effect of Angiotensin Receptor-Neprilysin Inhibitors (ARNi) and sodium-glucose transport protein 2 inhibitors (SGLT2i) on the mortality benefit of ICD in NIDCM.MethodsWe used a previous metanalysis algorithm and added an updated comprehensive literature search in PubMed for randomized control trials that examined the mortality benefit of ICD in NIDCM vs. optimal medical treatment. The primary outcome included death from any cause. We did a meta-regression analysis to search for a single independent factor affecting mortality. Using previous data, we evaluated the theoretical effect of ICD implementation on patients treated with SGLT2 inhibitors and ARNi.ResultsNo new articles were added to the results of the previous meta-analysis. 2,622 patients with NIDCM from 5 cohort studies published between 2002 and 2016 were included in the analysis. 50% of them underwent ICD implantation for primary prevention of sudden cardiac death, and 50% did not. ICD was associated with a significantly decreased risk for death from any cause compared to control (OR = 0.79, 95%CI: 0.66–0.95, p = 0.01, I2 = 0%). The theoretical addition of ARNi and the SGLT2 inhibitor dapagliflozin did not change the significant mortality effect of ICD (OR = 0.82, 95%CI: 0.7–0.9, p = 0.001, I2 = 0%) and (OR = 0.82, 95%CI: 0.7–0.9, p = 0.001, I2 = 0%). A meta-regression revealed no association between death from any cause and left bundle branch block (LBBB), use of amiodarone, use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers, year initiated enrollment, and the year ended enrollment (R2 = 0.0).ConclusionIn patients with NIDCM, the addition of ARNi and SGLT2i did not affect the mortality advantages of ICD for primary prevention.PROSPERO registry numberhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023403210.
Personalization strategies in digital mental health interventions: a systematic review and conceptual framework for depressive symptoms
Authors: Hornstein Silvan , Zantvoort Kirsten , Lueken Ulrike , Funk Burkhardt , Hilbert Kevin 
Published: May 2023

IntroductionPersonalization is a much-discussed approach to improve adherence and outcomes for Digital Mental Health interventions (DMHIs). Yet, major questions remain open, such as (1) what personalization is, (2) how prevalent it is in practice, and (3) what benefits it truly has.MethodsWe address this gap by performing a systematic literature review identifying all empirical studies on DMHIs targeting depressive symptoms in adults from 2015 to September 2022. The search in Pubmed, SCOPUS and Psycinfo led to the inclusion of 138 articles, describing 94 distinct DMHIs provided to an overall sample of approximately 24,300 individuals.ResultsOur investigation results in the conceptualization of personalization as purposefully designed variation between individuals in an intervention's therapeutic elements or its structure. We propose to further differentiate personalization by what is personalized (i.e., intervention content, content order, level of guidance or communication) and the underlying mechanism [i.e., user choice, provider choice, decision rules, and machine-learning (ML) based approaches]. Applying this concept, we identified personalization in 66% of the interventions for depressive symptoms, with personalized intervention content (32% of interventions) and communication with the user (30%) being particularly popular. Personalization via decision rules (48%) and user choice (36%) were the most used mechanisms, while the utilization of ML was rare (3%). Two-thirds of personalized interventions only tailored one dimension of the intervention.DiscussionWe conclude that future interventions could provide even more personalized experiences and especially benefit from using ML models. Finally, empirical evidence for personalization was scarce and inconclusive, making further evidence for the benefits of personalization highly needed.Systematic Review RegistrationIdentifier: CRD42022357408.
Active faults studies in Delhi and national capital region (NCR): Inferences from satellite data and field investigations
Authors: Dhali Mitthu , Gadhavi Mahendrasinh S. , Mohan Kapil , Narayana Pitta Poorvi , Malik Javed N. 
Published: May 2023

In recent years, the National Capital Region (NCR) of Delhi has experienced several earthquakes ranging in magnitude from 1.0 to 6.7. According to the last 50 years of earthquake data, the majority of earthquakes in the NCR have occurred near the Mahendragarh Dehradun Fault (MDF) and the Sohna Fault (SF). The region is bounded by a number of subsurface Ridges, Faults, and Lineaments, which are also influenced by the active plate boundary of the Indian and Eurasian plates. Active fault mapping is critical for the precise identification and marking of active fault traces in the NCR area for a precise seismic hazard assessment. We used high resolution Cartosat-1 stereopair data obtained from NRSC, Hyderabad, and Anaglyph (A 3D representation of the surface) and DEM prepared with ENVI software to map the active faults. We identified 12 sites in the NCR region based on satellite data interpretation, primarily along the MDF and Sohna Fault and their extensions. The presence of tectono-geomorphic markers along the MDF and Sohna Fault, such as warped surfaces indicative of fault scarps, stream offsets, gully erosion, and sag ponds, suggests active tectonic movement along these faults, most likely in the recent geological past. We believe the MDF is a right-lateral strike-slip fault with a compressional component on the western side and an extensional component on the eastern side. It acts as a segment boundary between compressional and extensional boundaries. We also identified the right lateral Nuh-Jhirka fault (NJF), which can be the Sohna Fault’s southern extension from Nuh to Jhirka. The western limb of the Delhi Mega fold has also seen a few right-lateral strike-slip movements that have extended up to the eastern bank of the Yamuna River, where the river reflects the base-level change and tight meandering on its upward side and a straight pattern on its downward side. This fault is known as the Delhi Fault (DF). The findings are preliminary, and further research would be required to create a detailed active fault map of the Delhi-NCR region to conduct a precise Seismic Hazard Assessment (SHA) of the region.
A dynamic learning method based on the Gaussian process for tunnel boring machine intelligent driving
Authors: Long Haitao , Lu Xiangqian , Ma Chunchi , Li Tianbin , Yan Wenjin , Zhang Hang , Dai Kunkun 
Published: May 2023

Introduction: The application of intelligent learning methods to the mining of characteristics and rules of time-series data has gained increasing attention with the rapid development of deep learning. One critical application of such methods is the intelligent assistant driving of tunnel boring machines (TBMs), for which the optimization of driving parameters is essential to improve construction efficiency. However, existing prediction models for TBM parameters are “static” and cannot dynamically capture parameter evolution during real-time driving cycles.Methods: In this study, we propose a novel dynamic learning model for TBM parameters by introducing the Gaussian process to address this problem. The model can learn decision-making experiences from historical driving cycles, dynamically update the model based on small sample data from current driving cycles, and simultaneously achieve driving parameter prediction. We focused on real-time prediction of TBM parameters in a tunnel project in western China.Results: The results show that the average relative errors of predicted total thrust and torque values were 1.9% and 2.7%, respectively, and the prediction accuracy was higher than that of conventional models such as random forest and long short-term memory. The model fully exploited updating of small samples of parameters, reducing the average time cost of the model to 29.7 s, which satisfies the requirements of efficient application.Discussion: The dynamic learning strategy of time-series data adopted in this study provides a reference for other similar engineering applications. The proposed model can improve the prediction accuracy of TBM parameters, thus facilitating the optimization of driving parameters and enhancing the construction efficiency of tunnels.Conclusion: In summary, this study establishes a dynamic learning model of TBM parameters that can dynamically capture parameter evolution and achieve accurate real-time driving parameter prediction. The proposed model can contribute to the development of intelligent assistant driving of TBMs and similar engineering applications.
Geological-geotechnical investigations of the historical Diriyah urban zone in Riyadh, Saudi Arabia: an integrated approach
Authors: Abdelrahman Kamal , Hazaea Saddam Ali , Almadani Sattam A. 
Published: May 2023

One hundred seventy geotechnical boreholes, two geo-seismic profiles of multichannel analyses of surface waves (MASW), and two geoelectrical cross-sections of electrical resistivity tomography (ERT) were carried out in the historical Diriyah urban zone. The borehole samples were analyzed for the geotechnical parameters of the standard penetration test (SPT N-value), the rock quality designation (RQD), and compressive strength (CS). Moreover, P- and S-wave velocities have been calculated. The measured SPT N-value has been corrected to amend the N60 parameter. According to the corrected N60, type, lithological, and soil profiles were divided into five distinct subsurface layers. It is indicated, for all recorded depths, these sediments become denser with depth where the values of N60 increase from 5 to 88 downward. According to grain size distribution, the major part of soil sites is composed of sand and varies from low to medium compressibility. The estimated RQD values range from 5 to 100 indicating rocks with significant variations in their geotechnical and physio-chemical characteristics. Furthermore, the compressive strength varies widely between 152.3 and 1,104.2 kg/cm2, which represents diverse geodynamic behavior under civil engineering constructions. Besides, the range of soil stiffness is indicated by the Shear-wave velocity (Vs) for soil layers, which varies from 171.3 to 456.2 m/s. According to the findings of the MASW profiles, the shear wave velocity is shown to be decreasing in MASW profile 1 between depths of 8 and 14 m, where the values range from 1,000 to 1,500 m/s, indicating a weak zone filled with secondary materials. But line 2 shows how the shear wave velocity decreased from depths of 5 m–11 m, where values ranged from 1,000 to 1,500 m/s, thus indicating a weak zone. The low resistivity zones in ERT cross-sections, which are found at the same depths in MASW profiles, are well associated with these findings. It can be concluded that there are a number of weak zones with varying depths, shapes, and dimensions found in the historical Diriyah urban zone’s near-surface deposits that civil engineers, urban planners, and urban developers should consider before undertaking any construction or developmental work involving civil engineering.
Experimental and DFT study of GO-decorated CaO quantum dots for catalytic dye degradation and bactericidal potential
Authors: Khan Mahreen , Ikram Muhammad , Haider Ali , Ul-Hamid Anwar , Ullah Hameed , Shahzadi Iram , Khan Sherdil , Kanoun Mohammed Benali , Goumri-Said Souraya , Medina Francisco , Nabgan Walid 
Published: May 2023

This research lays the groundwork for preparing graphene oxide (GO)-doped CaO nanocomposites for efficient antibacterial potential and dye degradation. The study aimed to reduce the recombination rate of the electron hole (e−/h+) of CaO and improve charge transfer. This issue can be minimized by doping high-surface area GO into CaO quantum dots (QDs). Herein, the one-pot co-precipitation technique has prepared various concentrations (1, 3, and 5 wt%) of GO-doped CaO. Characterization techniques were used to investigate optical, elemental analysis, microstructural, functional, and morphological properties. The addition of GO into QDs showed excellent catalytic activity (CA) to control sample CaO against methylene blue (MB) in basic and acidic media compared to the neutral media. The synergistic effect of morphological alternation attributed to an increase in the mechanism of CA upon doping. Various concentrations of GO to QDs promised remarkable bactericidal potency against Escherichia coli.
PD-1 inhibitors-based second-line therapy for metastatic gastric cancer
Authors: Gou Miaomiao , Zhang Yong , Wang Zhikuan , Dai Guanghai 
Published: May 2023

BackgroundMetastatic gastric cancer (MGC) patients with progression on first-line treatment still have poor outcomes on chemotherapy. The KEYNOTE-061 study demonstrated that pembrolizumab, a PD-1inhibitor, was not better than paclitaxel as second-line therapy for MGC. Herein, we explored the efficacy and safety of PD-1inhibitor based treatment for MGC patients in the second line.MethodsIn this observational, retrospective study, we enrolled MGC patients treated with anti-PD-1 based therapy as second-line in our hospital. We primarily assessed the treatment’s efficacy and safety. We also evaluated the relationship between clinical features and outcomes using univariate and multivariate analyses.ResultsWe enrolled 129 patients with an objective response rate (ORR) of 16.3% and a disease control rate (DCR) of 79.1%. Patients treated with PD-1inhibitor combined with chemotherapy and anti-angiogenic agents had ORR of 19.6% and higher DCR of 94.1%. The median progression-free survival (PFS) was 4.10 months, and the median overall survival (OS) was 7.60 months. In univariate analysis, patients treated with PD-1inhibitor combined with chemotherapy and anti-angiogenic agents and with prior anti-PD-1 history were significantly associated with favorable PFS and OS. In the multivariate analysis, different combination therapy and prior anti-PD-1 history were independent prognosis biomarkers for PFS and OS. Grade 3 or 4 treatment-related adverse events (TRAEs) occurred in 28 (21.7%) patients. Common adverse events (AEs) included fatigue, hyper/hypothyroidism, neutrophil decrease, anemia, skin reactions, proteinuria, and hypertension. We did not observe treatment-related deaths.ConclusionOur current results indicated that PD-1-inhibitor and chemo-anti-angiogenic agents combination therapy and prior PD-1 treatment history might improve clinical activity for GC immunotherapy as second-line treatment with acceptable safety profiles. Further studies are needed to verify those outcomes for MGC in other centers.