bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durability and microstructure analysis of concrete made with volcanic ash: A review (Part II)
Authors: Ahmad Jawad , Althoey Fadi , Abuhussain Mohammed Awad , Deifalla Ahmed Farouk , Özkılıç Yasin Onuralp , Rahmawati Cut 
Published: July 2023

Abstract
Concrete is the most frequently employed man-made material in modern building construction. Nevertheless, the serviceability of concrete structures has been significantly reduced owing to a variety of durability issues, especially when serving in a non-ideal environment and exposed to internal/external attacks such as chloride penetration, carbonation, sulfate, and so on. Several scholars have performed numerous studies on the strength and microstructure features of volcanic ash (VA) concrete and have discovered encouraging findings. However, since the information is spread, readers find it difficult to evaluate the benefits of VA-based concrete, limiting its applicability. As a result, a detailed study is required that offers the reader an easy approach and highlights all essential facts. The goal of this article (Part Ц) is to conduct a compressive review of the physical and chemical aspects of VA and its impact on concrete durability and microstructure properties. The findings demonstrate that VA considerably improves concrete durability owing to pozzolanic reaction and micro-filling voids in concrete materials. Cost–benefit analysis shows that 10% utilization of VA as cement decreased the overall cost by 30%. The assessment also notes a research gap that must be filled before VA may be utilized in practice.
Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome
Authors: Rusu Bianca , Kukreja Bharti , Wu Taiyi , Dan Sophie J. , Feng Min Yi , Kalish Brian T. 
Published: July 2023

AbstractDown syndrome (DS), the most common genetic cause of intellectual disability, is associated with lifelong cognitive deficits. However, the mechanisms by which triplication of chromosome 21 genes drive neuroinflammation and cognitive dysfunction are poorly understood. Here, using the Ts65Dn mouse model of DS, we performed an integrated single-nucleus ATAC and RNA-sequencing (snATAC-seq and snRNA-seq) analysis of the adult cortex. We identified cell type-specific transcriptional and chromatin-associated changes in the Ts65Dn cortex, including regulators of neuroinflammation, transcription and translation, myelination, and mitochondrial function. We discovered enrichment of a senescence-associated transcriptional signature in Ts65Dn oligodendrocyte (OL) precursor cells (OPCs) and epigenetic changes consistent with a loss of heterochromatin. We found that senescence is restricted to a subset of OPCs concentrated in deep cortical layers. Treatment of Ts65Dn mice with a senescence-reducing flavonoid rescued cortical OPC proliferation, restored microglial homeostasis, and improved contextual fear memory. Together, these findings suggest that cortical OPC senescence may be an important driver of neuropathology in DS.
Consistency across multi‐omics layers in a drug‐perturbed gut microbial community
Authors: Wuyts Sander , Alves Renato , Zimmermann‐Kogadeeva Maria , Nishijima Suguru , Blasche Sonja , Driessen Marja , Geyer Philipp E , Hercog Rajna , Kartal Ece , Maier Lisa , Müller Johannes B , Garcia Santamarina Sarela , Schmidt Thomas Sebastian B , Sevin Daniel C , Telzerow Anja , Treit Peter V , Wenzel Tobias , Typas Athanasios , Patil Kiran R , Mann Matthias , Kuhn Michael , Bork Peer 
Published: July 2023

AbstractMulti‐omics analyses are used in microbiome studies to understand molecular changes in microbial communities exposed to different conditions. However, it is not always clear how much each omics data type contributes to our understanding and whether they are concordant with each other. Here, we map the molecular response of a synthetic community of 32 human gut bacteria to three non‐antibiotic drugs by using five omics layers (16S rRNA gene profiling, metagenomics, metatranscriptomics, metaproteomics and metabolomics). We find that all the omics methods with species resolution are highly consistent in estimating relative species abundances. Furthermore, different omics methods complement each other for capturing functional changes. For example, while nearly all the omics data types captured that the antipsychotic drug chlorpromazine selectively inhibits Bacteroidota representatives in the community, the metatranscriptome and metaproteome suggested that the drug induces stress responses related to protein quality control. Metabolomics revealed a decrease in oligosaccharide uptake, likely caused by Bacteroidota depletion. Our study highlights how multi‐omics datasets can be utilized to reveal complex molecular responses to external perturbations in microbial communities.
How to Reflect on 20th Century Man Facing Dramatic Situations and Hard Choices?
Authors: Švedas Aurimas 
Published: July 2023

This article seeks to answer the question what ideas formed in the field of history theory can help develop a new interpretation of 20th century history, people facing difficult situations, the decisions they made, and, finally, traumatic individual and collective memory. The turbulent 20th century history and the memories about it is controversial; therefore, when contemporary Lithuanian society endeavors to discuss certain events, phenomena, and personalities and tries to come to a consensus on their immortalization – disagreements inevitably arise. In the process of research, it transpired that in contemporary historiography concerning the purpose and meaning of a historian’s work, as well as the responsibility to society of researchers of the past, several points are emphasized: (1) in the 21st century, historians have to find a new way of dealing with the complex issues of history; (2) scholars must recognize a responsibility for people who lived in the past and live the present, as well as to strive to show in the present perspective the fates of those who lived in the past; (3) the study of the past should contribute to the development of “intercultural competencies” which contemporary man lacks and which help him to understand The Other (past and present man); (4) to achieve these goals, historians need to transform their discipline into a “profession of understanding” that promotes inquisitiveness and openness to the world; (5) researchers of the past, when confronted with attempts to turn them into politicians or judges, have to leave the past open to new questions and interpretations; (6) those who study the past must engage in theoretical (self-)reflection that is necessary to perform the function of a critic that is so vital to society; and (7) historians need to think about the importance of the present dimension confronting complex historical issues. Historians work with collective memory to address the issues of self-awareness in time which face society. Researchers into the past also seek to initiate a dialogue between the people of the past and present. The conduct of the dialogue and its quality depend to a large extent on the level of the empathy that has been developed. Introducing empathy as a method for exploring knowledge about history and the present, this article draws on the ideas of George R. Collingwood, a British historian, archaeologist, and philosopher.
Límites y contradicciones del Programa de Fomento a la Economía Social 2021-2024 en México
Authors: Rojas Herrera Juan José 
Published: July 2023

El objetivo general del artículo consiste en realizar un análisis pormenorizado y multilateral del Programa de Fomento a la Economía Social 2021-2024, publicado el 21 de diciembre de 2021, a efecto de evaluar su consistencia técnica y determinar su grado de viabilidad política. Cabe destacar que el análisis exhaustivo y detallado del programa de mérito, se complementó y contrastó con diversas opiniones vertidas por informantes clave entre los que se encuentran dirigentes del movimiento cooperativo, funcionarios públicos y estudiosos del tema. Los resultados muestran que se trata de un diseño programático técnica y políticamente inviable en tanto carece de los elementos esenciales de sostenibilidad de cualquier política pública: presupuesto, personal suficiente y capacitado, infraestructura institucional, competencias jurídicas incuestionables y respaldo gubernamental.
Recibido: 25 junio 2022 Aceptado: 27 abril 2023
Cooperatives as a way of participation in political decision-making processes: An Examination over the Turkish Forestry Cooperatives in constitutional terms
Authors: Anıl Güven Yüksel 
Published: July 2023

In this article, cooperatives were examined on their distinctive structure, questioning whether they can be seen as a way of civil participation on political decision-making, by presenting some recent cases from Turkish Forestry Cooperatives. Firstly, the place of the civil society in participatory democracies and the importance of economic and social conditions in this perspective and consequently the role of the cooperatives in civil society were explained briefly. Afterwards, the cooperative’s practical impact on political decision-making was analysed over the instance of OR-KOOP including core information on cooperatives and forest villagers in Turkey —representing a community lower economic facilities— in the search of fundamental necessities for an expected participation in political decision-making processes. Finally, constitutional significance of the forests and the cooperatives were revealed with regard to the crossing concepts of participatory democracy, sustainable development and human rights.
Received: 29 July 2022 Accepted: 27 April 2023
Análisis del sabotaje de la Economía Social y de las cooperativas de ahorro y crédito en Ecuador
Authors: Luque González Arturo , Merino Chiliquinga Vanessa Estefanía , Aldas Vargas María del Carmen 
Published: July 2023

Ecuador a lo largo de la historia ha realizado grandes esfuerzos a través de procesos de economía social y solidaria —ESOL—. Muchos de estos procesos se han desplegado de manera informal a través de prácticas económicas no monetarias, y otros más formales a partir de la conceptualización y desarrollo de programas de economía popular y solidaria —EPS— afianzados en su nueva Constitución en el año 2008. A partir del año 2017 con el gobierno de Lenin Moreno se estableció una regresión en las políticas públicas y sociales llegando a su cúspide con el gobierno del banquero Guillermo Lasso a partir del año 2021. Es en ese momento cuando se despliegan todo tipo de medidas contra organizaciones que pudieran comprometer las cuentas de resultados de las estructuras económicas y oligarquías afines al gobierno entorpeciendo con ello procesos abiertamente democráticos como son las cooperativas de ahorro y crédito. Con ello se evidencia la falta de ética junto a la mala fe a la hora de no atender las necesidades de un sector que siempre ha sostenido y potenciado el flujo circulante de bienes y servicios a través de accionar local utilizando todo tipo de mecanismos priorizando la maximización del beneficio por encima del beneficio social.
Recibido: 17 noviembre 2022Aceptado: 02 mayo 2023
Zastosowanie Lotus corniculatus w badaniach biodegradacji TPH i WWA wspomaganej fitoremediacją
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Wojtowicz Katarzyna , Steliga Teresa ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: July 2023

W artykule przedstawiono zagadnienia związane z etapową bioremediacją gleby zanieczyszczonej substancjami ropopochodnymi. Badania procesu bioremediacji gleby G6 wykonywano w dwóch etapach. W etapie I przeprowadzono biodegradację zanieczyszczeń ropopochodnych na drodze inokulacji biopreparatem B1, opracowanym na bazie niepatogennych mikroorganizmów autochtonicznych. Badania prowadzono metodą pryzmowania ex situ przez okres 3 miesięcy w ściśle kontrolowanych warunkach temperaturowych. W II etapie badań wstępnie oczyszczoną glebę poddano procesowi biodegradacji (inokulacja biopreparatem B2) wspomaganej fitoremediacją w warunkach ex situ (metoda wazonowa) przez okres 6 miesięcy. W badaniach fitoremediacji wykorzystano komonicę zwyczajną (Lotus corniculatus), należącą do grupy naftofitów. Eksperymenty prowadzono w trzech układach: układ 1 – gleba G6-3 + komonica zwyczajna, układ 2 – gleba G6-3 + biopreparat B2 + komonica zwyczajna, układ 3 – gleba G6-3 + biopreparat B2 z dodatkiem γ-PGA (kwas γ-poliglutaminowy) + komonica zwyczajna. Oceny efektywności I i II etapu bioremediacji dokonano na podstawie przeprowadzonych analiz chromatograficznych i testów toksykologicznych. Zrealizowane badania wykazały, że efektywność I etapu bioremediacji gleby G6 wynosiła 41,67% dla TPH (całkowita zawartość węglowodorów) i 34,73% dla WWA (wielopierścieniowe węglowodory aromatyczne). Największą efektywność II etapu bioremediacji odnotowano w układzie 3, natomiast najniższą – w układzie 1. W wyniku II etapu bioremediacji wspomaganego fitoremediacją za pomocą komonicy zwyczajnej po 6 miesiącach badań osiągnięto spadek stężenia TPH w badanych układach o: 13,32% (układ 1), 39,65% (układ 2) oraz 51,79% (układ 3), natomiast efektywność II etapu biodegradacji WWA wynosiła 8,00% w glebie G6-3(1), 37,10% w glebie G6-3(2) oraz 51,34% w glebie G6-3(3). Wykonane testy toksykologiczne z zastosowaniem Phytotoxkit™, Ostracodtoxkit F™ oraz Microtox®SPT wykazały spadek właściwości toksycznych gleby po przeprowadzeniu procesu oczyszczania. Uzyskane wyniki analiz chromatograficznych i toksykologicznych wykazały, że wykorzystanie fitoremediacji w II etapie remediacji pozwala na zwiększenie efektywności procesu biodegradacji TPH i WWA.
Heat Transfer Included Simulation of Carbonate Rock Acidizing Using Two-Scale Continuum Model with Varying Rock Physics Curves
Authors: Nami M. H. , Ahmadi M. , Sharifi M. 
Published: July 2023

Summary
Matrix acidizing is the commonly used method to enhance permeability of a damaged zone around the well. Acid injection will dissolve the rock, creating narrow, high-permeability channels, called wormholes, to bypass the damaged zone. The pattern of wormhole generation indicates the efficiency of the well stimulation process. Although the injection rate has the most important role in this process, there are other factors such as rock properties, presence of an immiscible phase, and temperature variation that could also affect the dissolution pattern. A few studies have considered the simultaneous effects of all phenomena involved in the acidizing process. We have developed a two-phase heat transfer model coupled with a two-scale continuum model considering capillary and gravity forces for the first time, to simulate the wormhole dissolution pattern. It could be used to analyze the dissolution phenomenon of carbonate rock. A new two-phase relative permeability model is implemented to take the effect of dissolution on relative permeability curves into account. The influence of acid-rock temperature difference, reaction heat, nonisothermal condition, phase saturation, formation porosity, intrinsic permeability and heterogeneity on dissolution pattern, and number of injected pore volumes (PVs) before acid breakthrough is investigated in the developed model.
The simulation results show that both optimum injection rate and required PV of acid to breakthrough are strongly dependent on acid and rock temperatures. High formation temperature increases both the optimum injection rate and the optimum number of injected PVs before breakthrough. Injection of acid at lower temperatures will decrease both the optimum injection rate and the optimum number of injected PVs to break through. Simulation results show that the optimum number of injected PVs to break through is 8% higher when reaction heat is considered. Formation properties and degree of heterogeneity influence the number of required injected PVs to breakthrough. Low porosity formations with high heterogeneity correspond to the lowest number of injected PVs to breakthrough. The results indicated that formations with higher permeability will have a higher optimum number of injected PVs to break through and an optimum injection rate. Simulated results show that increasing the initial water saturation will increase the volume of acid to breakthrough. Variation in initial water saturation has a minor effect on wormhole shape, but it does not change the dissolution regime.
Adaptive Basis Function Selection Enhanced Multisurrogate-Assisted Evolutionary Algorithm for Production Optimization
Authors: Wang Jialin , Zhang Kai , Zhang Liming , Wang Jian , Peng Wenfeng , Yan Xia , Wang Haochen , Zhang Huaqing , Yang Yongfei , Sun Hai , Liu Piyang , Chen Haichuan , Fang Xiaokun 
Published: July 2023

Summary
Surrogate-assisted evolutionary algorithms (SAEAs) have become a popular approach for solving reservoir production optimization problems. The radial-basis-function network (RBFN) is a robust surrogate model technology suitable for reservoir development with numerous wells and a long production lifetime. There are several types of basis functions for constructing RBFN models. However, existing research shows that selecting the basis function with competitive performance for the current optimization problem is challenging without prior knowledge. In conventional SAEAs, the basis function is often predetermined, but its prediction accuracy for the problem at hand cannot be guaranteed. Furthermore, canonical SAEAs usually employ only one surrogate model for the entire optimization process. However, relying on a single surrogate model for optimization increases the probability of search direction misdirection due to prediction deviations. In this paper, a novel method named adaptive basis function selection enhanced multisurrogate-assisted evolutionary algorithm (ABMSEA) is introduced for production optimization. This method mainly includes two innovations. First, by training and testing different types of basis functions, the one with the best prediction performance is adaptively selected. Second, the ensemble model is constructed using the bootstrap sampling method, comprising multiple global surrogate models based on the selected best basis function. To search for a set of solutions that perform well on multiple surrogates, we employ an efficient multiobjective optimization (MOO) algorithm called nondominated sorting genetic algorithm II (NSGA-II). This algorithm uses the surrogates themselves as objective functions, aiming to find solutions that yield favorable results across multiple surrogates. The proposed method improves the efficiency of production optimization while enhancing global search capabilities. To evaluate the effectiveness of ABMSEA, we conduct tests on four 100D benchmark functions, a three-channel model, and an egg model. The obtained results are compared with those obtained from differential evolution (DE) and three other surrogate-model-based methods. The experimental results demonstrate that ABMSEA exhibits an accurate selection of competitive basis functions for the current optimization period while maintaining high optimization efficiency and avoiding local optima. Consequently, our method enables optimal well control, leading to the attainment of the highest net present value (NPV).
High-intensity exercise increases breast milk adiponectin concentrations: a randomised cross-over study
Authors: Holmen Mads , Giskeødegård Guro F , Moholdt Trine 
Published: July 2023

AbstractAdiponectin plays a role in glucose and fat metabolism and is present in breast milk. Circulating adiponectin increases acutely after endurance exercise. The purpose of this randomised, cross-over study was to determine the acute effects of exercise on adiponectin concentrations in human breast milk. Participants (N = 20) completed three conditions in the lab: 1) Moderate-intensity continuous training (MICT), 2) High-intensity interval training (HIIT), and 3) No activity (REST). At each condition, we collected breastmilk at 07:00 hours (before exercise/rest), 11:00 hours (immediately after exercise/rest), 12:00 hours (1 hour after exercise/rest), and 15:00 (4 hours after exercise/rest) and determined adiponectin concentrations using enzyme-linked immunosorbent assay. We compared changes in adiponectin concentrations after MICT and HIIT, adjusted for the morning concentration on each test day, with those after REST, using paired t-tests. Adiponectin concentrations increased 1 hour after HIIT, from 4.6 (± 2.2) μg/mL in the 07:00 hours sample to 5.6 (± 2.6) μg/mL. This change was 0.9 μg/mL (95% confidence interval 0.3 to 1.5) greater than the change between these two timepoints in the REST condition (p= .025). There were no other statistically significant changes in adiponectin concentrations. HIIT may increase adiponectin concentrations in breast milk acutely after exercise.
Formin-like 1 β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse
Authors: Izquierdo Manuel , Ruiz-Navarro Javier , Fernández-Hermira Sara , Sanz-Fernández Irene , Barbeito Pablo , Garcia-Gonzalo Francesc , Calvo Víctor 
Published: July 2023

Abstract

T-cell receptor stimulation by antigen bound to the major histocompatibility complex (MHC) on an antigen-presenting cell (APC) induces protein kinase C (PKC) activation and the formation of the immune synapse (IS), followed by depletion of filamentous actin (F-actin) at the central region of the IS (cIS) and the polarization of multivesicular bodies (MVB) and the microtubule-organizing center (MTOC) to the IS. These events lead to polarized exosome secretion at the IS. These exosomes are involved in several crucial immune responses such as autocrine activation-induced cell death (AICD) of T lymphocytes and citotoxicity. We analysed here how formin-like 1 β (FMNL1β), an actin cytoskeleton-regulatory protein, regulates MTOC/MVB polarization and exosome secretion at the IS in a phosphorylation-dependent manner. IS formation was associated with transient recruitment of FMNL1β to the IS, which was independent of protein kinase C δ (PKCδ). Simultaneous RNA interference of all FMNL1 isoforms prevented MTOC/MVB polarization and exosome secretion, which was restored by FMNL1β expression. However, expression of the non-phosphorylatable mutant FMNL1βS1086A did not restore neither MTOC/MVB polarization nor exosome secretion to control levels, supporting the crucial role of S1086 phosphorylation in MTOC/MVB polarization and secretion. In contrast, the phosphomimetic mutant, FMNL1βS1086D, restored MTOC/MVB polarization and exosome secretion. Conversely, FMNL1βS1086D mutant did not recover the deficient MTOC/MVB polarization occurring in a PKCδ-interfered clone, indicating that S1086 phosphorylation alone is not sufficient for MTOC/MVB polarization and exosome secretion. FMNL1 interference inhibited the depletion of F-actin at the cIS, which is necessary for MTOC/MVB polarization. FMNL1β and FMNL1βS1086D, but not FMNL1βS1086A expression, restored F-actin depletion at cIS. Thus, actin cytoskeleton reorganization at the IS underlay the effects of all these FMNL1β variants on polarized secretory traffic. Taken together, these results point out a crucial role of S1086 phosphorylation in FMNL1β activation, leading to cortical actin reorganization and subsequent control of MTOC/MVB polarization and exosome secretion.