bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rehabilitación oral completa en un paciente con erosión dental causada por reflujo gastroesofágico
Authors: Ramírez González Jacqueline , Figueroa Aguirre Diana Lizette , Alatorre Castorena Olivia , Romero Jiménez Marco Octavio , Niño Camacho Andrés , Correia Miranda Valdivia Andréa Dolores 
Published: May 2023

Introducción: la erosión dental es la pérdida irreversible de estructura dentaria debido a un proceso químico, sin presencia de bacterias, causada por la acción de ácidos que pueden ser de origen extrínseco, intrínseco o ambos. Algunos de los signos de la erosión dental incluyen facetas planas y suaves en las superficies palatinas y vestibulares, así como concavidades superficiales en las caras oclusales. Una causa intrínseca es la presencia de ácido por reflujo gastroesofágico, las causas extrínsecas tienen que ver con la alta ingesta de alimentos ácidos. La enfermedad por reflujo gastroesofágico (ERGE) se ha asociado con problemas dentales como erosión, halitosis, patología de la mucosa y bruxismo. Se pueden encontrar distintos procedimientos para la rehabilitación oral de pacientes con ERGE, entre los cuales se encuentran los procedimientos adhesivos que preservan mayor cantidad de estructura dental sana. Objetivo: realizar el reporte de caso de un paciente con erosión dental causada por ERGE. Presentación del caso: paciente masculino de 32 años de edad que acudió a la clínica de la especialidad de prostodoncia; en el examen intraoral se observaron atriciones por bruxismo y erosiones generalizadas causadas por reflujo gastrointestinal. La restauración de la erosión dental debe basarse en un método conservador y mínimamente invasivo. La técnica de tres pasos que se utilizó para la rehabilitación completa, de acuerdo a la técnica de Francesca Vailati, Urs Cristoph Belser, está estructurada para lograr una rehabilitación adhesiva completa con resultados predecibles y una mínima cantidad de preparación dental. Conclusiones: la terapia restauradora de la erosión dental debe basarse en un método mínimamente invasivo. La enfermedad por reflujo gastroesofágico se ha asociado con problemas dentales como erosión dental, halitosis, patología de la mucosa y bruxismo. Por lo general, los pacientes con ERGE refieren manifestaciones orales de la enfermedad, lo que revela la importancia del tratamiento multidisciplinario y el seguimiento de estos pacientes.
Proteoma salival: alcances y perspectivas para el diagnóstico y monitoreo de la enfermedad periodontal. Revisión de la literatura
Authors: Flores-Reyna Luis Alonso , Martínez-Hernández Miryam 
Published: May 2023

Introducción: esta revisión de la literatura examina los cambios en el proteoma salival relacionados con la presencia de periodontitis que pueden ser utilizados para el diagnóstico y seguimiento de la enfermedad, esto es posible debido a que la saliva total contiene una variedad de mediadores locales derivados de las respuestas microbianas y del huésped, así como marcadores sistémicos (plasma) que pueden ser útiles en el diagnóstico periodontal. Objetivo: documentar los cambios reportados en el proteoma salival asociados con la presencia de periodontitis con potencial para ser utilizados en el diagnóstico y monitoreo de la enfermedad. Material y métodos: las bases de datos PubMed, SpringerLink, Google Académico, WILEY y ScienceDirect fueron consultadas utilizando los términos de búsqueda "salivary proteome AND salivary diagnosis; salivary protein profile AND periodontal disease AND periodontitis" con el fin de identificar publicaciones que reportaran cambios en el perfil proteico salival de sujetos diagnosticados con periodontitis. Se incluyeron artículos de revisión, artículos originales publicados en revistas indexadas y documentos de consenso en los idiomas inglés y español. Resultados: proteínas salivales como α-amilasa, cistatina-C y mucina-5B fueron reportadas como aumentadas por algunos autores, mientras que proteínas como cistatina-SN, lactoperoxidasa y mucina-7 fueron reportadas como disminuidas cuando se comparó el proteoma salival de sujetos sistémicamente sanos con periodontitis contra sujetos sin periodontitis. Estos resultados confirman la existencia de cambios en el proteoma salival asociados con la presencia de periodontitis. Conclusiones: los cambios en el proteoma salival asociados con la presencia de periodontitis identificados en la presente revisión de la literatura requieren ser investigados a mayor profundidad debido a su potencial para ser utilizados en el diagnóstico y monitoreo de la periodontitis.
The use of janus kinase inhibitors anti-interleukin therapy in the Russian Federation with COVID-19: pharmacoepidemiological study
Authors: Gomon Yu. M. , Strizheletsky V. V. , Ivanov I. G. , Kolbin A. S. , Kalyapin A. A. , Fakhrutdinova A. M. , Usmanova T. A. 
Published: May 2023

The objective of this study was to assess the volume of consumption of anti-interleukins and janus kinase inhibitors in the period 2018–2021, used as well as preventive pathogenetic therapy of COVID-19.Materials and methods. Based on actual sales data in the segments of public procurement (including regional and federal preferential drug provision) and retail sales segment in the period 2018–2021, obtained from the IQVIA database. All data was recalculated into the number of established daily doses (DDDs), with the calculation of pharmacoepidemiological indicators «Incidence of prescribing drugs», «Cumulative risk of prescribing drugs», as well as «Prescribing prevalence per year» for tocilizumab, olokizumab, levilimab, sarilumab, kanakinumab, anakinra, baricitinib, tofacitinib and upadacitinib.Results and discussion. The growth of total sales volumes was demonstrated in all market segments, but mostly in the segment of regional purchases, primarily related to the purchase of these groups of medicines for COVID-19 therapy in the period 2020–2021. It was demonstrated that the increase in the number of cases, accompanied by the expansion of prescribing preventive pathogenetic therapy, led to a twofold increase in the number of new cases of prescribing of janus kinase inhibitors and an increase in this indicator for anti-interleukins by 1.5 times, taking into account the estimated number of patients with moderate and severe COVID-19. The cumulative risk of prescribing these classes of drugs increased proportionally: for JAK inhibitors from 14 to 32%, and for anti-IL drugs from 38 to 69%. Calculations showed that the proportion of people over 18 years of age in the Russian Federation who received at least one dose of janus kinase inhibitors and anti-interleukins increased many times, in 1000 times and 500 times.Conclusions. Taking into account the expansion of the use of these groups of medicines, careful monitoring of information about their safety is required.
Efectos de la política monetaria en las finanzas de las familias. Una revisión desde la inclusión y educación financieras en Colombia (2010-2019).
Authors: Ruiz - Escobar Raúl David , Velásquez - Castañeda Lauren Sofía 
Published: May 2023

El siguiente artículo pretende analizar a partir de un marco conceptual y datos históricos de los rubros si los agentes privados se comportan de acuerdo con los marcos teóricos de la teoría del comportamiento y como estas actitudes están relacionadas con los efectos de la política monetaria en las decisiones de consumo, ahorro, gasto e inversión de los hogares, a fin de identificar las premisas que guían el comportamiento de las familias
Mais que e para-além do racismo: meditações teóricas e políticas sobre antinegritude
Authors: Jung Moon-Kie , Vargas João H. Costa 
Published: May 2023

Este artigo tece considerações sobre antinegritude e a distingue do racismo, expondo a falsa universalidade do Social e do Humano: o racismo ocorre no Social entre os Humanos, enquanto a antinegritude continuamente expulsa os negros e a negritude dessas categorias modernas fundamentais cujas definições derivam da expulsão violenta. Para delinear a discussão, o artigo analisa dois textos paradigmáticos que se esforçam para lidar intransigentemente com a antinegritude, mas através da linguagem do racismo: George Yancey, Who Is White? e "The Combahee River Collective Statement." O artigo conclui sugerindo a necessidade de um salto de invenção fanoniano e uma abrangente abolição.
DAMPAK TRAUMATIS REMAJA KORBAN TINDAKAN KEKERASAN SEKSUAL SERTA PERAN DUKUNGAN SOSIAL KELUARGA
Authors: Ramadhani Salsabila Rizky , Nurwati R Nunung 
Published: May 2023

Banyaknya pemberitaan mengenai kasus kekerasan seksual khususnya pada remaja sangat mengguncang hati nurani setiap orang karena remaja usia sekolah merupakan kelompok yang rentan dan memiliki tingkat ketergantungan yang tinggi pada orang dewasa. Kekerasan seksual terhadap remaja di samping berdampak secara fisiknya seperti masalah kesehatan, dampak secara psikis juga akan dialami korban seperti stres dan traumatis. Dampak yang muncul dari kekerasan seksual kemungkinan adalah depresi, fobia, dan mimpi buruk, curiga terhadap orang lain dalam waktu yang cukup lama. Tujuan yang hendak dicapai dalam penelitian ini adalah untuk mendeskripsikan seberapa besar dampak yang dialami korban kekerasan seksual dan bagaimana dukungan sosial keluarga dapat membantu korban untuk mengembalikan kepercayaan dirinya sehingga dapat berfungsi kembali secara sosial. Dalam penulisan artikel ini menggunakan metode deskriptif kualitatif. Hasil dari kajian ini menemukan; setelah korban mengalami kekerasan seksual dapat mengalami Post Traumatic Stress Disorder (PTSD). Keberadaan dan peran serta keluarga khususnya orang tua (bukan pelaku kekerasan) sangat penting dalam membantu anak dalam proses memulihkan diri dan penyesuaian pasca mengalami kekerasan seksual, seperti dukungan sosial yang diberikan oleh keluarga dapat berdampak besar pada proses pemulihan anak korban kekerasan seksual seperti dukungan sosial dan emosional, meningkatkan komunikasi dengan anak, keterlibatan orang tua terhadap proses penanganan kekerasan seksual yang dialami anak, dan sebagainya. The number of reports regarding cases of sexual violence, especially among teenagers, has shaken everyone's conscience because school-age teenagers are a vulnerable group and have a high level of dependence on adults. Sexual violence against teenagers in addition to having a physical impact such as health problems, psychological impacts will also be experienced by victims such as stress and trauma. The impact that arises from sexual violence may be depression, phobias, and nightmares, suspicious of others for a long time. The objectives to be achieved in this study are to describe how big the impact experienced by victims of sexual violence and how family social support can help victims to restore their self-confidence so that they can function again socially. In writing this article using a qualitative descriptive method. The handling and healing of psychological trauma due to sexual violence needs special attention such as the social support provided by the family can have a major impact on the recovery process of children victims of sexual violence such as social and emotional support, improving communication with children, parental involvement in the process of handling sexual violence experienced by children, etc.
Sustainable Business Development Via Applying an Online Business Model for Gaining Benefit in Economics, Education, and Social Network
Authors: Purnomo Rochmat Aldy , Malynka Oksana , Prananto Adi 
Published: May 2023

Regional development includes infrastructure and information technology. Infrastructure, Information and Communication Technology (ICT) is worse in rural areas and small towns in Indonesia. One of such areas is the village of Menowo located in Magelang, Central Java Province, Indonesia. The purpose of this research is to study a contemporary phenomenon of the Blogger Village within its real-life content. In this research, a case study is described: a young man who was born in the village has started an “online business community”. Now, people call the Village Menowo “The Blogger Village”. Since 2014, more than 50 people in the Blogger Village have got their own revenue accounts for hundreds of thousands of U.S. dollars per month. The Blogger Community has contributed to reducing unemployment in the village. The study has found that the Blogger Community can provide additional income for Magelang SMEs. Magelang SMEs can use the profit margin of their businesses to update hardware and software including Internet information sources from anywhere. The study provides new information related to the regional development, local development, and complement economic empirical studies of a research that has been done before. The applied research is beneficial for the Government of Magelang to determine and develop policies of the regional economic development of Magelang and to establish appropriate programs and activities for developing the economy of the area. The research will also help eliminate the overlap among the existing rules both at central and local levels, as well as among sectors and agencies.
KDM3A, a Novel Blood-Based Biomarker in Colorectal Carcinogenesis
Authors: Polat D. , Onur E. , Yılmaz N. , Sökücü M. , Gerçeker O.F. 
Published: May 2023

ABSTRACT
Colorectal cancer (CRC) is one of the leading causes of cancer-linked deaths globally. The determination of biomarkers is important in the prognosis and treatment of CRC. Previous studies emphasized the relationship between hypoxia and CRC in humans, and there is strong evidence that this process is strongly related to HIF-1. KDM3A is a histone demethylase that could directly bind to HIF-1α, a subunit of HIF-1. This study aimed to reveal whether the expression level of the KDM3A gene could be used as a predictor of CRC. The expression levels of HIF-1α, KDM3A, and Epithelial-Mesenchymal Transition (EMT) genes were evaluated by qRT-PCR in leukocyte samples of 50 CRC patients in different stages and 50 healthy controls. HIF-1α and KDM3A expression levels were significantly higher in the CRC group, compared to the controls. Slug and ZEB-1 genes, the mesenchymal markers, showed the same significance pattern between groups. We acquired 0.664 AUC with 54% sensitivity and 85.4% specificity for separating controls from CRC patients by using the KDM3A expression levels in ROC analysis. This data support that KDM3A could be a novel supplementary biomarker in diagnosis of CRC, which could be noninvasively detected in circulation.
Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases
Authors: Ioannidou M. , Tsotridou E. , Samoladas E. , Tragiannidis A. , Kouskouras K. , Sfougaris D. , Spyridakis I. , Foroulis C. , Galli-Tsinopoulou A. , Hatzipantelis E. 
Published: May 2023

ABSTRACT
Ewing sarcoma (ES), described as a diffuse endothelioma of the bone, is divided into two categories: osseous and extraosseous, which mainly affects adolescents. Extraosseous Ewing Sarcomas (EES) are rare tumors originating from soft tissues. Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. The diagnosis of EES was confirmed by biopsy and cytogenetic analysis with fluorescence in situ hybridization (FISH). Surgical excision was planned as primary treatment, followed by adjuvant chemotherapy according to EURO-E.W.I.N.G protocol. To date, all patients are alive, 1, 3 and 4 years after completion of treatment, with no signs of recurrence or metastasis.
BRCA 1/BRCA 2 Pathogenic/Likely Pathogenic Variant Patients with Breast, Ovarian, and Other Cancers
Authors: Osman K. , Ahmet K. , Hilmi T. , İlker N.O. , Ercan Ö. , Devrim Ç. , Murat S. , Emre Ç. , İlhan H. , Mustafa G. , Yüksel Ü. , Bahiddin Y. , Cihan E. , Mehmet Ali N. Ş. , Emrah E. , Umut D. , Zeynep O. , Mehmet Ali K. , Ali G. , İvo G. , Erkan Ö. , Muhammet B.H. , Bülent E. , Selma D. , Sernaz U. , Mahmut G. , Hakan G. , İrfan Ç. 
Published: May 2023

ABSTRACT
The demographic and clinical characteristics of patients who have BRCA 1/BRCA 2 pathogenic/likely pathogenic variants may differ from their relatives who had BRCA-related cancer. In this study, we aimed to demonstrate the clinical and demographic findings of patients who had BRCA-related cancer and to assess the differences comparing their relatives who had BRCA-related cancer with breast, genital tract, prostate, and pancreas cancers as well. The results of sequencing analysis of 200 cancer patients (190 women, 10 men) who have been directed to genetic counseling with an indication of BRCA1/BRCA2 testing from different regions across 9 medical oncology centers were retrospectively analyzed. A total of 200 consecutive cancer patients who harbored the BRCA1/BRCA2 pathogenic/likely pathogenic variant (130 (65%) patients harbored BRCA 1 pathogenic/likely pathogenic variant, and 70 harbored BRCA 2 pathogenic/likely pathogenic variant) were included. Of these, 64.0% had breast cancer (43.8% of them had the triple-negative disease, and about 2.3% had only the HER-2 mutant), 31.5% had genital cancers (92.1% of them had ovarian cancer, 3.2% had endometrium, and 1.6% had peritoneum cancer as the primary site and mostly serous adenocarcinoma was the most common histopathology and 14.3% of the patients had endometrioid adenocarcinoma), 3.5% had prostate (median time from metastasis to castration-resistant status was 28 months) and 1.0% had pancreas cancer. Newly diagnosed cancer (breast and ovary) patients who had BRCA 1/BRCA 2 pathogenic/ likely pathogenic variant were younger than their previous cancer diagnosed (breast, ovary, and pancreas) parents who harbored BRCA pathogenic/likely pathogenic variant. We suggest that the genetic screening of BRCA 1/ BRCA 2 pathogenic/likely pathogenic variant is needed as a routine screening for those with a personal or family history of breast, ovarian, tubal, or peritoneal cancer. In addition, once BRCA 1 or BRCA 2 germline pathogenic variant has been identified in a family, testing of at-risk next-generation relatives earlier can identify those family members who also have the familial pathogenic variant, and thus need increased surveillance.
High Risk of Gestational Trophoblastic Neoplasia Development in Recurrent Hydatidiform Moles with NLRP7 Pathogenic Variations
Authors: Kocabey M. , Gulhan I. , Koc A. , Cankaya T. , Karatasli V. , Ileri A. 
Published: May 2023

ABSTRACT

Objective
Pathogenic variations of the NLRP7 and KHDC3L genes are responsible for familial recurrent hydatidiform moles, a rare autosomal recessive phenomenon that can lead to severe comorbidities. Little is known about the diversity of genetic defects or the natural course of disease progression among recurrent hydatidiform mole cases from distinct ethnicities. In this study, we aimed to investigate the mutation profile and pregnancy outcomes in patients with multiple molar pregnancies.

Material and Methods
Three unrelated cases with recurrent molar pregnancies are included in this study. None of the patients had a known family history of molar pregnancy. Clinical findings and follow-up results are documented. Sanger sequencing is used to reveal genetic defects in exons and exon-intron boundaries of NLRP7 and KHDC3L genes.

Results

NLRP7 pathogenic variants were found in all three cases. In two cases, homozygous, c.2471+1G>A canonical splice cite variant was identified and in one case a homozygous, c.2571dupC (p.Ile858HisfsTer11) frameshift variant was identified. No variant in the KHDC3L gene was found in any case. In all cases, the development of gestational trophoblastic neoplasia complicated the clinical course and the treatment plans.

Conclusions
We found that defects of the NLRP7 gene are principally responsible for etiology in our region, and the mutation profile suggests a founder effect in the Turkish population. We suggest early genetic diagnosis and counseling in molar pregnancies and recommend close follow-up in terms of conversion to gestational trophoblastic neoplasia.
Climatically Determined Spatial and Temporal Changes in the Biomass of Betula spp. of Eurasia in the Context of the Law of the Limiting Factor
Authors: Usoltsev Vladimir Andreevich , Lin Hui , Shobairi Seyed Omid Reza , Tsepordey Ivan Stepanovich , Ye Zilin 
Published: May 2023

Abstract
Forest ecosystems play an essential role in climate stabilization, and the study of their capabilities in this aspect is of paramount importance. How climate changes affect the biomass of trees and stands in transcontinental gradients is unknown today? The objective of this study was (a) to verify the operation of the law of the limiting factor at the transcontinental level when modeling changes in the biomass of trees and stands of the genus Betula spp. of Eurasia in relation to geographically determined indicators of temperatures and precipitation, and (b) to show the possibility of using the constructed climate-conditioned models of tree and stand biomass in predicting temporal changes in tree and stand biomass based on the principle of space-for-time substitution. As a result of the implementation of the principles of the limiting factor and space-for-time substitution, a common pattern has been established on tree and stand levels: in sufficiently moisture-rich climatic zones, an increase in temperature by 1 °C with a constant amount of precipitation causes an increase in aboveground biomass, and in moisture-deficient zones, it decreases; in warm climatic zones, a decrease in precipitation by 100 mm at a constant average January temperature causes a decrease in aboveground biomass, and in cold climatic zones, it increases.
Forest Provisioning Ecosystem Services in Babile Elephant Sanctuary, Ethiopia
Authors: Hussein Abdulbasit , Workeneh Sintayehu 
Published: May 2023

Abstract
The study was conducted at Babile Elephant Sanctuary (BES) to identify and document the use and importance of provisioning ecosystem services (ESs). ESs were identified using questionnaire surveys from 110 households in three villages located inside and adjacent to BES by random sampling method. The importance attributed to each ES was evaluated using a descriptive rank analysis. Ordered logistic regressions were used to test whether and how socioeconomic factors influenced the importance attributed to ESs. The most used services were determined based on the percentage of respondents who used a particular service. Fodder, fuelwood, and construction were ranked the most important and used ESs. Age and gender significantly played important roles in people’s perceptions of the importance of ESs. This result suggests that the consequence of human-induced disturbance on woody species diversity and natural forest ESs appeared to be negative depending on the type and intensities of the disturbances.