bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallaphotoredox‐Catalyzed Enantioselective Cross‐Electrophile Coupling Using Alcohols as Reducing Agents
Authors: Li Zhilong , Huan Leitao , Li Jian , Shu Xiaomin , Zhong De , Zhang Wenjing , Huo Haohua 
Published: June 2023

AbstractThe cross‐electrophile coupling (XEC) represents a powerful strategy for C−C bond formation. However, controlling the enantioselectivity in these processes remains a challenge. Here, we report an unprecedented enantioselective XEC of α‐amino acid derivatives with aryl bromides, enabled by alcohols as reducing agents via Ni/photoredox catalysis. This mechanistically distinct approach exploits the ability of photocatalytically generated α‐hydroxyalkyl radicals to convert alkyl electrophiles to the corresponding alkyl radicals that are then enantioselectively coupled with aryl bromides. The readily scalable protocol allows modular access to valuable enantioenriched benzylic amines from abundant and inexpensive precursors, and is applicable to late‐stage diversification with broad functional group tolerance. Mechanistic studies rationalize the versatility of this alcohol‐based reactivity for radical generation and subsequent asymmetric cross‐coupling. We expect that this alcohol‐based cross‐coupling will render a general platform for the development of appealing yet challenging enantioselective XECs.
One‐Handed Helical Polyacetylenes Bearing Axially‐Chiral 2‐Arylpyridyl‐N‐Oxide Units for Efficient Chromatographic Enantioseparation of Chiral Aromatic and Aliphatic Alcohols
Authors: Ikai Tomoyuki , Ito Masaki , Oki Kosuke , Suzuki Nozomu , Yashima Eiji 
Published: June 2023

AbstractA series of poly(biarylylacetylene)s (PBAs) bearing axially‐chiral (S)‐and (R)‐pyridyl‐N‐oxide residues with a methoxy, propoxy, or acetyloxy substituent at the 3‐position of the biaryl units was synthesized. All the PBAs formed a preferred‐handed helix, while the helical sense preference was varied depending on the substituents despite the same twist‐sense of the biaryl units. Among them, the propoxy‐bound helical PBA showed an exceptionally high chiral recognition ability as a chiral stationary phase (CSP) for high‐performance liquid chromatography (HPLC) and efficiently resolved not only various chiral aromatic alcohols, but also a variety of chiral aliphatic alcohols; the latter still remains difficult to resolve by commercially‐available CSPs in HPLC. Such practically‐useful both handed helical PBA‐based CSPs can be produced from the racemic PBA composed of fully racemic monomer units through deracemization of the biaryl units with a chiral alcohol.
Large‐Scale Analysis of Meniscus Morphology as Risk Factor for Knee Osteoarthritis
Authors: Gao Kenneth T. , Xie Emily , Chen Vincent , Iriondo Claudia , Calivà Francesco , Souza Richard B. , Majumdar Sharmila , Pedoia Valentina 
Published: June 2023

ObjectiveAlthough it is established that structural damage of the meniscus is linked to knee osteoarthritis (OA) progression, the predisposition to future development of OA because of geometric meniscal shapes is plausible and unexplored. This study aims to identify common variations in meniscal shape and determine their relationships to tissue morphology, OA onset, and longitudinal changes in cartilage thickness.MethodsA total of 4,790 participants from the Osteoarthritis Initiative data set were studied. A statistical shape model was developed for the meniscus, and shape scores were evaluated between a control group and an OA incidence group. Shape features were then associated with cartilage thickness changes over 8 years to localize the relationship between meniscus shape and cartilage degeneration.ResultsSeven shape features between the medial and lateral menisci were identified to be different between knees that remain normal and those that develop OA. These include length‐width ratios, horn lengths, root attachment angles, and concavity. These “at‐risk” shapes were linked to unique cartilage thickness changes that suggest a relationship between meniscus geometry and decreased tibial coverage and rotational imbalances. Additionally, strong associations were found between meniscal shape and demographic subpopulations, future tibial extrusion, and meniscal and ligamentous tears.ConclusionThis automatic method expanded upon known meniscus characteristics that are associated with the onset of OA and discovered novel shape features that have yet to be investigated in the context of OA risk.
Spirally Configuredcis‐Stilbene/fluorene (STIF), 10,11‐Benzo‐, and Imidazole‐fused STIF Hybrids as Electron‐Transporting Materials for Organic Light‐Emitting Diode Applications
Authors: Chen Chien‐Tien , Fang Po‐Hsun , Jou Jia‐Hong , Chen Wei‐Hua 
Published: June 2023

AbstractA new class ofcis‐stilbene/fluorene (STIF) and 10,11‐benzo‐ and imidazole‐fused dibenzosuberane/fluorene (Bz‐STIF and Imd‐STIF) spiro hybrid systems with paired cyanophenyl, pyridyl, and/or pyrimidyl units was synthesized as electron transporting materials (ETMs) for blue fluorescent OLEDs (FOLEDs) and phosphorescent organic light emitting diodes (PhOLEDs). Their photophysical (UV‐Vis absorption and emission), electrochemical (Eox/Ered), morphological (glassy transition temperature, Tg), and thermal stability (decomposition temperature, Td) properties are systematical compared. Their correlations regarding the effects of the fused unit/substituent(s) in the STIF core on the morphological/thermal stability, HOMO/LUMO energy level, π‐electron distribution profiles by DFT calculations, and electron mobility are established. Blue FOLEDs are fabricated by using them and TmPyPB (a control) as ETMs. The effects of their LUMO energy levels and electron mobilities on the device turn‐on voltage, performance efficiencies including external quantum efficiency/current efficiency (EQE/CE), power efficiency (PE), and device lifetime at 5% luminescence decay (T95) are correlated. Among them, three best ETMs and TmPyPB (a control) are selected for further green and blue PhOLED fabrications. The effects of their LUMO energy levels and electron mobilities on the device turn‐on voltage and performance efficiencies are confirmed, allowing for potential commercial applications.
Parent treatment of complex pica in a teen with autism
Authors: Thomas Benjamin R. , Bowman Matthew D. , Sanchez Aaron , Strohmeier Craig W. 
Published: June 2023

AbstractPica is a severe behavior disorder involving the persistent consumption of nonnutritive substances. Due to health complications and risks for fatality, designing effective behavioral treatments that are feasible for implementation by family members at home is imperative. This case report presents a parent‐conducted functional analysis and treatment evaluation of automatically maintained pica in a teenager with autism spectrum disorder. Initial treatment with a competing stimulus was effective when paired with response interruption and redirection. Although effective, this combination of treatment components required very close parental proximity and led to increases in untargeted body‐oriented pica (e.g., ingestion of skin, hair, and nails). Upon extending treatment to include the second topography of pica, both the originally targeted (object‐oriented) pica and body‐oriented pica decreased. Nonetheless, treatment effects were not sustained while fading parent proximity. The treatment was then augmented a third time with response cost. This final treatment package produced clinically significant reductions in all pica, facilitated parent proximity fading until the participant was alone, extended to their home, and maintained over a year of follow up.
Nanoemulsion‐directed assembly of hierarchical ZnS@C nanospheres with penetrating pores for sodium storage
Authors: He Xiaowei , Zhuo Sifei , Tian Lidong , Qiao Mingtao , Lei Xingfeng , Zhang Hepeng , Zhang Qiuyu 
Published: June 2023

AbstractTo follow up on the performance of lithium‐ion batteries (LIBs), transition metal sulfides (TMSs) have been developed as promising carbon alternatives for sodium‐ion batteries (SIBs). Although attractive, it is still a great challenge to fulfill their capacity utilization with high cycling performance. Herein, a nanoemulsion‐directed method has been developed to control the spherical arrangement of ZnS@C units with both penetrating macropores from the center to the surface and inner mesopores distributed among the bulks. With respect to ion diffusion, the penetrating macropores could serve as the built‐in ion‐buffer reservoirs to keep a steady flow of electrolyte, while the inner mesopores facilitate the ion diffusion across the whole bulks. In terms of stability, the radical porous structure could work as self‐supported vertical bones to accommodate the volume change from both lateral and vertical sides. Besides, the localized carbon distributed among the ZnS nanoparticles not only acts as binding agents to join the numerous ZnS nanoparticles but also endows the radical bones with effective electron transmission capability. As a proof of concept, such hydrangea‐like ZnS@C nanospheres deliver sodium storage performance with high‐rate and long‐cycling capability. This nanoemulsion‐directed approach is anticipated for other TMSs with penetrating pores for post‐lithium‐ion batteries applications.
Incidence, demographics, and survival of malignant hemangioendothelioma in the United States
Authors: Paulson Kelly G. , Ravi Vinod , Rubin Brian P. , Park Min , Loggers Elizabeth T. , Cranmer Lee D. , Wagner Michael J. 
Published: June 2023

AbstractBackgroundMalignant hemangioendothelioma is an endothelial cancer with heterogeneous clinical behavior that can range from indolent to aggressive, of which the majority are epithelioid (EHE). Its incidence and demographics have not been previously well defined in a large cohort.MethodsThis retrospective analysis used the US Cancer Statistics National Program of Cancer Registries – Surveillance Epidemiology End Results (SEER) combined database to identify patients in the US newly diagnosed with hemangioendothelioma between the years of 2001 and 2017 (n = 1986). Survival analyses were performed on a subset of patients within the SEER‐18 database with survival information available (n = 417). Outcomes included incidence, demographics of patients newly diagnosed with hemangioendothelioma, extent of disease at presentation, and overall survival.ResultsThe incidence of hemangioendothelioma in the US is 0.4 cases per million person‐years. Although cases rose to 122 newly diagnosed in the year 2017 (90 EHE, 32 other hemangioendothelioma), incidence rates were stable. Skin and connective tissues were the most common presenting sites (33.4%), followed by liver (24.5%), lung (17.6%), and bone (12.5%). Median age at diagnosis was 55 years; 27.2% of patients were pediatric, adolescent, or young adult (<40 years). At presentation, 36.4% of patients had localized disease; 21.6% presented with regional and 41.7% with distant metastases. Observed survival at 3 years was 79.7%, 70.7%, and 46.0% for patients presenting with local, regional, and distant disease and most deaths occurred within the first 2 years.ConclusionsMalignant hemangioendothelioma is ultra‐rare but meaningfully impacts affected patients. These data may provide benchmarks for comparison of new approaches to hemangioendothelioma therapy and highlight poor survival outcomes.
Effects of mental accounting on purchase decision processes: A systematic review and research agenda
Authors: Skwara Florian 
Published: June 2023

AbstractThis paper aims to systematically analyze and synthesize the existing research published on mental accounting and purchase decision processes by conducting a systematic literature review. Specifically, the paper aims to answer the question: “What are the effects of mental accounting on purchase decision processes?” Therefore, it identified 110 papers which contribute to achieving the research objective and which were selected using the same data collection, data analysis, and quality standards. After reviewing the identified publications, the paper finds that the existing literature can be structured along four main themes impacting purchase decision‐making processes: (1) source of funds, (2) intended use of funds, (3) pricing, and (4) payments. The paper shows that for each of the four themes there are multiple mental accounting effects with an impact on for example willingness to pay, the experienced pain of paying or the ultimate purchase decision. Further, the paper identifies potential directions for future research in mental accounting, including the influence of product categories on mental accounting, flexibility in budget setting and its impact on mental accounting behavior, long‐term effects of mental budgeting on financial wealth, integration–segregation behavior in the context of pricing, the role of consumer characteristics on mental accounting behavior, and the impact of increased financial transparency through technology on mental accounting.
A rare presentation of visceral leishmaniasis and epididymo‐orchitis in a patient with chronic granulomatous disease
Authors: Ashraf Talesh Shaghayegh , Mahmoudi Shima , Mohebali Mehdi , Mamishi Setareh 
Published: June 2023

AbstractVisceral leishmaniasis (VL) has rarely been reported in patients with chronic granulomatous disease (CGD), despite the fact that they seem more susceptible to intracellular infection. We describe a rare presentation of VL and epididymo‐orchitis in a patient with CGD, which has not been seen previously in the literature following inflammatory syndrome.
Bending the ORR Scaling Relations on Zirconium Oxynitride for Enhanced Oxygen Electrocatalysis
Authors: Sinha Sukanya , Vegge Tejs , Hansen Heine Anton 
Published: June 2023

AbstractTechnologies like polymer electrolyte membrane fuel cells play an important role in environmentally friendly energy conversion. Essential for their commercialization is the development of cheap and efficient electrocatalyst for the oxygen reduction reaction (ORR). Non‐platinum group metal (PGM) based catalysts has exhibited favourable activity in acidic electrolytes. In this study, we computationally explore the catalytic sites on the (111) surface of hydrated zirconium oxynitride using periodic DFT calculations. The thermodynamically limiting step is determined to be the O2 activation step, (O2→OOH*) for the majority of the sites, hence strengthening the OOH* intermediate binding will improve ORR activity. The calculations also reveal that the determined scaling relation for GOH‐GOOH (
3.52 eV) is comparable to the standard ORR scaling relation (
3.2 eV) however GO*‐GOH scaling (
2.16 eV) deviates dramatically from the typical ORR scaling relation (
).
Defect Engineering in Bimetallic NiFe‐BTC for Boosting Electrocatalytic Oxygen Evolution Reaction through Coordinated Ionic Liquids
Authors: Li Ru , Qi Haodong , Pan Fenghongkang , Xie Wei , Zhou Lihui , Liu Honglai , Hu Jun 
Published: June 2023

AbstractCoordinatively unsaturated metal (CUM) sites in metal organic frameworks (MOFs) have demonstrated distinct catalytic activities, yet remain great challenges in their designing and engineering. Herein, a novel “Coordination Geometric Hindrance” approach based on ionic liquids (ILs) is proposed for defects construction in bimetallic MOF, of which the steric effect of competitively coordinated anions of imidazole ILs ([EMIM]X) enables the interference with the ordered growth of bimetallic NiFe‐MOFs. Specifically, the PF6− anion displays the strongest binding energy with metals Ni and Fe, accordingly, facilitates the formation of CUM sites in NiFe‐BTC/IL‐PF6. Taking both advantages of CUM defects and good intrinsic conductivity of IL, NiFe‐BTC/IL‐PF6 achieves a superior electrocatalytic performance in the oxygen evolution reaction (OER), with the overpotential as low as 210 mV at 10 mA cm−2, and the Tafel slope of 103 mV dec−1, thus, giving an 18‐fold larger TOF of the commercial OER catalyst of RuO2.
Monomer Recycling and Repolymerization of Post‐Consumer Polyester Textiles
Authors: Kirstein Mathias , Lücking Charlotte , Biermann Lars , Brepohl Esther , Salikov Vitalij , Eichert Carsten , Paschetag Mandy , Scholl Stephan 
Published: June 2023

AbstractDue to the presence of dyes and additives, textile recycling is challenging, therefore the majority of textile waste is downcycled to low‐value products, incinerated or landfilled. In this study, a continuous depolymerization of post‐consumer polyester textiles was conducted by alkaline hydrolysis. The degree of depolymerization was assessed and found to be 94 %. After recovering and analyzing the terephthalic acid and ethylene glycol the monomers were successfully polymerized to regain a food grade quality recycled polyethylene terephthalate. The presented recycling approach allows a closed‐loop recycling of textiles.
Improved modelling and simulation of once‐through and reverse multi‐stage flash desalination configurations
Authors: Ali Emad , Orfi Jamel , AlAnsary Hany , Alsaadi Ahmad S. , Ghaffour Noreddine , Khennich Mohammed 
Published: June 2023

AbstractAn improved model for multistage flash (MSF) structures is developed and used to assess the performance of a novel MSF configuration, termed as MSF reversal (RV‐MSF) and consisting of reversing the brine circulation stream. The improved model determines the temperature distribution within the stages using heat balance equations while the simplified one, which is commonly used, is based on pre‐specified, constant, and equal temperature distribution throughout the stages. The performance of the RV‐MSF is investigated and compared with conventional MSF once‐through (OT‐MSF) with and without brine mixing using simplified and full models. It is found that the simplified model overestimates the required heat transfer specific area for both MSF configurations. Moreover, it underestimates the cooling water and energy requirements for the reversal configuration. Hence, the simplified model may be good for quick analysis but leads to inaccurate design specifications and economic analysis. When brine mixing is utilized, the simplified model still provides erroneous estimates of the heat transfer area for both MSF configurations. Nevertheless, for OT‐MSF structure, the simple model can provide comparable predictions with that of the improved model in terms of recovery ratio, performance ratio, and specific energy consumption. For the RV‐MSF structure, a mismatch in the two model predictions of surface area, cooling water, and energy requirements is observed. Furthermore, the temperature drop in the cooling system for RV‐MSF has a significant influence on the specific surface area and cooling water requirements especially at low values. The different behaviour of the simplified model between the OT‐MSF and RV‐MSF configurations is attributed to the fact that brine recycling does not affect the feed temperature or the temperature distribution in the system.
Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis
Authors: Chen Jiani , Wang Huan , Zhang Chen , Shi Le , Zhang Qianqian , Song Xiaole , Wang Dehui , Hu Li , Yu Hongmeng , Sun Xicai 
Published: June 2023

AbstractBackgroundTo compare the safety and efficacy between endoscopic sinus surgery and different biologics in treating chronic rhinosinusitis with nasal polyps in adults by reviewing the existing clinical trials.MethodsData extraction and risk of bias assessment were conducted by 2 independent reviewers according to the PRISMA recommendations and any disagreement was resolved by a third investigator. Outcomes were measured through a random‐effects model. We searched Embase, Web of Science, MEDLINE, Cochrane, and other relevant sources from its inception to April 30, 2022. We included randomized controlled trials(RCTs) involving endoscopic sinus surgery (ESS) or biologics in treating adult patients with chronic rhinosinusitis with nasal polyps. Studies involving other miscellaneous diseases, non‐RCT design, and insufficient participants or follow‐up were excluded.ResultsIn this systematic review, five RCTs and 1748 patients were included. All the biologics, as well as ESS, could significantly improve key nasal outcomes in CRSwNP both at 6 months and 1 year. Dupilumab exhibited better efficacy than ESS in improving SNOT‐22 scores at one year. However, ESS showed superiority over three biologics in improving nasal congestion scores (NCS) at two various time points, except for better efficacy of Dupilumab at 1 year. For the loss of smell scores, a greater improvement was observed in the Dupilumab cohort compared with other biologics and even ESS counterparts. Safety analysis showed no significant difference between the ESS cohort and biologic treatment.ConclusionsIn summary, ESS showed comparable improvement in quality of life and symptoms to Omalizumab, Mepolizumab, and Benralizumab. Dupilumab seems to be more effective than ESS in selected items, whereas head‐to‐head trials and real‐world studies are urgent to compare their efficacy. Our findings also showed that biologics could be applied as alternative or adjuvant therapy for uncontrolled severe CRSwNP.
Advances in Functionalized Nanomaterial‐incorporated Biosensing Platforms for Detecting Cancer Biomarkers during Biopsies
Authors: Ser Jinhui , Lee Hyunjung , Surendran Subramani , Kim Jung Kyu , Sim Uk , Cho Hoonsung 
Published: June 2023

AbstractSensors incorporating nanomaterials are being studied with great interest in the field of diagnostics given their high‐sensitivity and accuracy due to the unique advantages of nanomaterials. Cancer is one of the leading causes of death in humans, with its early detection significantly reducing the risk of death and improving treatment prognosis. The gold standard for the early diagnosis of cancers is pathological and genetic analysis of tumor biopsy specimens. Unfortunately, standardization of techniques for separating and quantifying biomarkers from tumor biopsies requires more sensitive, accurate, and rapid early detection techniques. The development of biosensing platforms utilizing various functional nanomaterials is expected to realize the isolation and detection of biomarkers, thereby enabling rapid and accurate early cancer diagnosis. Therefore, this review aims to explore cutting‐edge nanomaterials that fall within the scope of highly sensitive analytical technology biosensor platforms to introduce the transducer platform of biosensing systems using functionalized nanomaterials for the selective recognition and detection of signal‐specific cancer biomarkers. It will pave the way for highly precise cancer detection, providing a unique means to carefully monitor the different types of biopsy sample of patients.