bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptom Burden, Coagulopathy and Heart Disease after Acute SARS- CoV-2 Infection in Primary Practice - Results from the Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland (SETANTA)
Authors: Colleran Roisin , Fitzgerald Sean , Rai Himanshu , McGovern Laurna , Byrne Roger J. , Mansur Ahmed , Cradock Andrea , Lavery Ros , Bisset James , McKeogh Shane , Cantwell Gordon , O’Ciardha Darach , Wilson Hannah , Begossi Nicoletta , Blake Nial , Fitzgibbon Maria , McNulty Jonathan , Széplaki Gábor , Heffernan Emma , Hannan Margaret , O’Donnell James P. , Byrne Robert A. 
Published: June 2023

Abstract
Purpose:
The aim of SETANTA (Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland) study was to investigate symptom burden and incidence of cardiac abnormalities after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 and correlate these results with immunological response and biomarkers of coagulation.
Methods:
SETANTA was a prospective, single-arm observational cross-sectional study in a primary practice setting, prospectively registered with ClinicalTrials.gov identifier: NCT04823182. Patients with recent COVID-19 infection ≥6 weeks and ≤12 months before enrolment were enrolled. Primary outcomes of interest were markers of cardiac injury detected by cardiac magnetic resonance imaging (MRI), including left ventricular ejection fraction, late gadolinium enhancement and pericardial abnormalities, and serum biomarker levels.
Results:
100 patients (n= 129 approached) were included, 64% were female. Mean age was 45.2 years. The median (interquartile range) time interval between COVID-19 infection and enrolment was 189 [125, 246] days. 83% had at least one persistent symptom. 96% had positive serology for prior SARS-CoV-2 infection. Late gadolinium enhancement, pericardial effusion, was present in 2.2% and 8.3% respectively; left ventricular ejection fraction was below the normal reference limit in 17.4% of patients. Von Willebrand factor antigen was elevated in 32.7% of patients. Fibrinogen and D-Dimer levels were raised in 10.2% and 11.1% of patients, respectively.
Conclusion:
In a cohort of primary practice patients recently recovered from SARS-CoV-2 infection, prevalence of persistent symptoms and markers of abnormal coagulation were high, despite a lower frequency of abnormalities on cardiac MRI compared with prior reports of patients assessed in a hospital setting.
Trial Registration:
Clinicaltrials.gov, NCT04823182 (prospectively registered on 30th March 2021)
New type of cross-conjugated cyclopentanones as of ketocyanine dye - 2-arylidene-5-((dimethylamino)methylene)cyclopentanones: synthesis and photophysical properties
Authors: Batalin Sergey 
Published: June 2023

Abstract
A simple and efficient method for the synthesis of a new type of ketocyanine dye based on 2-arylidene-5-((dimethylamino)methylene)cyclopentanone by reaction of 2-arylidenecyclopentanones with dimethylformamide dimethyl acetal was discovered. The fluorescent properties of the synthesized compounds are considered depending on the structure, the polarity of medium.
Synthesis, Crystal Structure and Antimicrobial activities of Two Silver(I) Complexes Based on Bis(pyrazole) and Carboxylic Acid Co-ligands
Authors: Yang Hong , Zhang Heng-Hui , Li Changqing , Guo Li-Jun , Yang Miao , Hu Tuoping 
Published: June 2023

Abstract
Two dinuclear and centrosymmetric silver-containing complexes namely [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(tbtc)] (1) and [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(dbtc)] (3,5-dmpz: dimethypyrazole; 3,5-dmpz methanol: 3,5-dimethylpyrazole methanol; tbtc: Tetrabromoterephthalic acid; dbtc: 2,5-Dibromoterephthalic acid) were prepared and characterized. X-ray crystallographic data of 1 and 2 revealed that trigonal environment of the Ag ions have a “Compressed Y’s” geometry. The antimicrobial activity of 1 and 2 was tested against the Gram-positive, Gram-negative bacteria and fungus, displaying the better inhibiting activity than the individual AgNO3 and 3,5-dimethylpyrazole, especially for Candida albicans (IC50-2.54 mg mL− 1 and 2.79 mg mL− 1). The quantified IC50 values displayed that complexes 1 and 2 were more effective against fungus than the Gram-negative bacteria and Gram-positive bacteria.
A three-dimensional model with two-body interactions for endothelial cells in angiogenesis
Authors: Sakai Kazuma , Hayashi Tatsuya , Mada Jun , Tonami Kazuo , Kurihara Hiroki , Tokihiro Tetsuji 
Published: June 2023

Abstract
We introduce a three-dimensional mathematical model for the dynamics of vascular endothelial cells during sprouting angiogenesis. Angiogenesis is the biological process by which new blood vessels form from existing ones. It has been the subject of numerous theoretical models. These models have successfully replicated various aspects of angiogenesis. Recent studies using particle-based models have highlighted the significant influence of cell shape on network formation, with elongated cells contributing to the formation of branching structures. While most mathematical models are two-dimensional, we aim to investigate whether ellipsoids also form branch-like structures and how their shape affects the pattern. In our model, the shape of a vascular endothelial cell is represented as a spheroid, and a discrete dynamical system is constructed based on the simple assumption of two-body interactions. Numerical simulations demonstrate that our model reproduces the patterns of elongation and branching observed in the early stages of angiogenesis. Furthermore, we show that the pattern formation of the cell population is strongly dependent on the cell shape. Our study is expected to contribute to the understanding of how lumen structures are formed in the future.
CEREBRAL ABSCESS WITH HYDROCEPHALUS MANIFESTATION: A CASE REPORT IN 10-MONTH-OLD INFANT
Authors: UTOMO NUNKI PUSPITA , ASTUTI MERARI PANTI 
Published: June 2023

<p class="p1"><strong>Background </strong>Alongside hydrocephalus, cerebral abscess poses as space-occupying lesion altering consciousness and intracranial pressure. Cerebral abscesses commonly presented vague clinical symptoms in infants, including weeks of fever and late-onset neurologic deterioration. However, limited studies denote cerebral abscesses, especially in children under one year old.<span class="Apple-converted-space"> </span></p><p class="p1"><strong>Objective </strong>We reported a case of a 10-month-old male infant with cerebral abscess and hydrocephalus.</p><p class="p1"><strong>Case description</strong> A 10-month-old male infant was taken to the hospital due to 6 days progressing fever. Neither clinical nor laboratory findings were abnormal. After being discharged from the hospital, the patient has admitted again 2 days later, reserved for 5 days of fever until unfortunate symptoms of raised intracranial pressure coincide with hypothermic body temperature. A brain CT-Scan showed an area of hypodense lesion in the parieto-occipital region suspected of brain abscess- resulting in non-communicating hydrocephalus. After a total of 12 days of intensive treatment with antibiotics, anti-convulsant, and steroid agents, the patient was comatose and passed away due to respiratory failure.<span class="Apple-converted-space"> </span></p><p class="p1"><strong>Conclusion</strong> Brain abscesses should be investigated thoroughly despite the probable absence of a pathognomonic feature. Radiology imaging ought to demonstrate the early process of abscess pathogenesis. To the best of our knowledge, this is the first case report published in Indonesia of an infant with a cerebral abscess resulting in hydrocephalus.</p>
Assessment of impact of climate change on the streamflow of Idamalayar River Basin, Kerala
Authors: Reshma C. , Arunkumar R. 
Published: June 2023

Abstract

This study investigates the impacts of climate change on water availability in the Idamalayar basin, Kerala. Soil and Water Assessment Tool (SWAT), Hydrologic Engineering Centre – Hydrologic Modelling System (HEC-HMS), and bias-corrected climate change data were used to simulate future streamflows. The performances of SWAT and HEC-HMS were assessed using four statistical indices (R2, Nash–Sutcliffe efficiency, percentage bias, and RSR). SWAT slightly outperformed HEC-HMS. The CMIP6 general circulation models (GCMs) were selected using PROMETHEE-2. The variations in climate variables and streamflows were studied for three future periods, i.e., near-future (2031–2040), mid-future (2051–2060), and far-future (2071–2080) under three shared socio-economic pathway (SSP) scenarios (SSP126, SSP245, and SSP585). The projections of GCMs show different patterns in variation of precipitation. Generally, there is a slight increase in annual precipitation. However, there was a notable decline in peak in July. An additional peak was often seen in October. The maximum and minimum temperatures showed a decreasing trend. The average annual streamflow reduction under SSP126 was approximately 25.63, 27.92, and 26.24% in the near, mid, and far future, respectively. Under SSP245, the average decrease was 30.71, 16.06, and 19.06% for the near, mid and far future, respectively. For SSP585, there was 12.73% increase in the far-future period.
A review of microplastic removal from water and wastewater by membrane technologies
Authors: Acarer Seren 
Published: June 2023

Abstract

Microplastics (MPs) cannot be completely removed from water/wastewater in conventional wastewater treatment plants (WWTPs) and drinking water treatment plants (DWTPs). According to the literature analysis, membrane technologies, one of the advanced treatment technologies, are the most effective and promising technologies for MP removal from water and wastewater. In this paper, firstly, the properties of MPs commonly present in WWTPs/DWTPs and the MP removal efficiency of WWTPs/DWTPs are briefly reviewed. In addition, research studies on MP removal from water/wastewater by microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), reverse osmosis (RO), and membrane bioreactors (MBRs) are reviewed. In the next section, membrane filtration is compared with other methods used for MP removal from water/wastewater, and the advantages/disadvantages of the removal methods are discussed. Moreover, the problem of membrane fouling with MPs during filtration and the potential for MP release from polymeric membrane structure to water/wastewater are discussed. Finally, based on the studies in the literature, the current status and research deficiencies of MP removal by membrane technologies are identified, and recommendations are made for further studies.
Cognitive Deficits: Verbal and Semantic Fluency in People Living with
HIV and AIDS
Authors: Ivanova Ganka , Alhrahsheh Rakan , Kukov Kaloyan 
Published: June 2023

Background:
Since the beginning of the HIV epidemic, the virus has taken millions of
lives worldwide. The United Nations AIDS Fund’s statistics reported that deaths caused by HIVrelated
conditions and AIDS were about 39 million from the beginning of the epidemic to 2015. The
united global efforts to fight the virus are considerably changing the indicators, such as mortality
and morbidity, but the challenges remain. The total number of people living with HIV in Bulgaria as
of 12th May, 2015, was 2,121. As of 30th November, 2016, the official data reported 2 460 people
living with HIV. As of 13th February, 2017, 2 487 individuals were HIV-seropositive. Approximately
60% of people with HIV are prone to developing cognitive impairment due to the infection.

Objective:
This study aimed to know the level of cognitive deficiency, in particular, the verbal and
semantic fluency of people living with HIV and AIDS

Methods:
In this study, a comparative analysis was carried out. The Stewart test was used to compare
the average independent samples. For clarity, the average values, the test statistics, and the estimated
significance levels are presented in the tables. Additionally, a statistical mechanism of factor
selection was used by the forward stepwise method. The Wilks' Lambda statistic reported values
between 0 and 1, with values close to zero indicating good discrimination of the model.

Results:
According to this research, the HIV positives participants generated fewer verbs than the
ones from the control group. The data were partially confirmed by the present study. There were
differences in terms of both adjectives and nouns among people living with HIV and AIDS.

Conclusion:
The study data proves that language deficits are detectable in neurocognitive testing of
HIV. The overall hypothesis of the study has been confirmed. The language impairments are primarily
qualitative and can be used as a marker for the initial and subsequent therapy assessment.
The Predictors of Hepatorenal Syndrome Development in HCV Cirrhotic
Ascitic Egyptian Patients with Spontaneous Bacterial Peritonitis
Authors: El Sharawy Shimaa Mahmoud , Elkadeem Mahmoud Zaki , Amer Ibrahim Fathi 
Published: June 2023

Background & Aims:
Spontaneous bacterial peritonitis is considered a precipitating factor for renal impairment in patients with liver cirrhosis. No specific study addressing this problem has been reported. This study aimed to detect the incidence and predictive factors of hepatorenal syndrome in these patients.

Materials and Methods:
This study enrolled 121 hepatic cirrhotic patients with spontaneous bacterial peritonitis. History taking, clinical examination, and laboratory investigations includ-ing ascitic fluid analysis were carried out. Kidney function tests were repeated 3 days after the initiation of treatment. Patients were divided into 2 groups after one week of treatment during the follow-up period: Group I: patients without hepatorenal syndrome, and Group II: patients with hepatorenal syndrome. Multivariate analysis was performed to determine independent predictors of hepatorenal syndrome development.

Results:
A total of 30 patients (24.8%) developed hepatorenal syndrome. Patients with hepato-renal syndrome had significantly lower sodium and albumin levels as well as higher creatinine, bilirubin, Child-Turcotte-Pugh score, portal vein diameter, Model for End-Stage Liver Disease score. Higher percentage of them had a history of recurrent spontaneous bacterial peritonitis and multiple therapeutic paracentesis of ascites. Multivariate analysis detected that serum bili-rubin, Model for End-Stage Liver Disease-Sodium, and portal vein diameter were significant predictors of hepatorenal syndrome. Cutoff values were determined as 3.3 mg/dl for bilirubin, 15.9 mm for portal vein diameter, and 26 for Model for End-Stage Liver Disease-Sodium.

Conclusion:
Hepatorenal syndrome is a common complication of spontaneous bacterial peritonitis. In our study, high serum bilirubin, Model for End-Stage Liver Disease-Sodium, and portal vein diameter are predictors of the development of hepatorenal syndrome in patients with spontaneous bacterial peritonitis.
Reproductive and Biochemical Toxicity of Biobased Silver Nanoparticles against Toxocara vitulorum
Authors: Bahaaeldine Manar Ahmed , Garhy Manal El , Fahmy Sohair R. , Mohamed Ayman Saber 
Published: June 2023

Background:
Toxocara vitulorum is a common parasitic worm of buffalo and cattle, causing livestock mortality and morbidity worldwide. Several countries suffered substantial eco-nomic losses due to animal death and reduced meat and milk production. Therefore, it became nec-essary to discover a new alternative drug, especially with the emerging resistance to current medica-tions. The present study aims to evaluate the in vitro anthelmintic effect of different concentrations of biobased silver nanoparticles on T. vitulorum adults.

Methods:
Different concentrations of silver nanoparticles were synthesised using lemon juice. Groups of male and female adult worms were incubated in 50, 100, and 200 mg/L silver nanoparti-cles for 48 h. The parasite motility, histology, and biochemical parameters were observed and com-pared to the control.

Results:
The results showed that silver nanoparticles decreased the worm motility, increased mor-tality rate, induced structural damage, caused collagen disruption, and showed elevated levels of as-partate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin, total protein, urea, and creatinine, as well as reduced levels of acetylcholinesterase, lactate dehydrogenase, uric acid, total cholesterol, triglycerides, and high-density lipoprotein in a dose-dependent manner.

Conclusion:
Silver nanoparticles established a significant anthelmintic effect against T. vitulorum and could become one of the up-and-coming antiparasitic drugs in the future.
Epidemiology and Perception of Acne Among Adolescents in Jos, Nigeria: Cross-Sectional School-Based Study
Authors: Adah Ruth , Yusufu Hope , Otene Queen-Amina Vivian 
Published: June 2023

Background
Adolescents who make up a vast majority of the secondary school population are at a stage at which they are largely affected by acne. This condition, which is widely visible and easily recognized by peers, has numerous misperceptions surrounding it, which may influence attitudes toward people affected by it. There is a paucity of information on the prevalence of acne and how adolescents in Jos, Nigeria, view the condition.

Objective
This study aimed to determine the prevalence of acne, perceived risk factors, and the accuracy of self-report among adolescents in Jos, Nigeria. The study also sought to understand perceptions surrounding acne in this age group.

Methods
This descriptive cross-sectional study was conducted among adolescents attending private and public secondary schools in Jos, Nigeria. In total, 482 students were recruited through a multistaged stratified random sampling method. A self-administered semistructured questionnaire was used to collect information on history of acne, perceptions of causes, and the attitude toward those who have the condition. All participants were examined for the presence of acne. Univariate, bivariate, and multivariate analysis were conducted using SPSS (version 26; IBM Corp).

Results
The self-reported prevalence of acne was 44% and that upon clinical examination was 55%. Self-report showed a moderate degree of agreement with clinical diagnosis (Cohen κ=57.3%; P<.001). Predictive factors for the presence of acne in general were age of ≥15 years (odds ratio [OR] 1.79, 95% CI 1.12-2.87; P=.02), being in a private school (OR 2.17, 95% CI 1.38-3.42; P=.001), and being in a senior secondary class (OR 2.14, 95% CI 1.32-3.47; P=.002). The female gender (OR 3.03, 95% CI 1.64-5.61; P=.001) and religion (OR 3.24, 95% CI 1.27-8.24; P=.02) were predictive for acne only among adolescents aged <15 years, while a positive family history was predictive in those aged ≥15 years (OR 2.04, 95% CI 1.15-3.61; P=.02). A distinct perception and attitude pattern surrounding acne was observed, as a significant proportion (84/131, 64.1% vs 47/131, 35.9%; P=.02) of those who related acne to a biological phenomenon had acne themselves; however, the belief that acne is caused by skin lightening practices was significantly more common in those without acne (19/28, 67.9%) than in those with acne (9/28, 32.1%; P=.01). One-fourth of the adolescents (n=122, 25.3%) had no idea of the possible causes of acne.

Conclusions
Though acne is a prevalent skin condition among Nigerian adolescents, many misperceptions and unfavorable attitudes surround acne and persons affected by the condition. Our findings have revealed the need to work with the school health program to educate the general adolescent population about acne, to refer and manage teenagers with acne.
Staying Home, Tweeting Hope: Mixed Methods Study of Twitter Sentiment Geographical Index During US Stay-At-Home Orders
Authors: Xia Xinming , Zhang Yi , Jiang Wenting , Wu Connor Yuhao 
Published: June 2023

Background
Stay-at-home orders were one of the controversial interventions to curb the spread of COVID-19 in the United States. The stay-at-home orders, implemented in 51 states and territories between March 7 and June 30, 2020, impacted the lives of individuals and communities and accelerated the heavy usage of web-based social networking sites. Twitter sentiment analysis can provide valuable insight into public health emergency response measures and allow for better formulation and timing of future public health measures to be released in response to future public health emergencies.

Objective
This study evaluated how stay-at-home orders affect Twitter sentiment in the United States. Furthermore, this study aimed to understand the feedback on stay-at-home orders from groups with different circumstances and backgrounds. In addition, we particularly focused on vulnerable groups, including older people groups with underlying medical conditions, small and medium enterprises, and low-income groups.

Methods
We constructed a multiperiod difference-in-differences regression model based on the Twitter sentiment geographical index quantified from 7.4 billion geo-tagged tweets data to analyze the dynamics of sentiment feedback on stay-at-home orders across the United States. In addition, we used moderated effects analysis to assess differential feedback from vulnerable groups.

Results
We combed through the implementation of stay-at-home orders, Twitter sentiment geographical index, and the number of confirmed cases and deaths in 51 US states and territories. We identified trend changes in public sentiment before and after the stay-at-home orders. Regression results showed that stay-at-home orders generated a positive response, contributing to a recovery in Twitter sentiment. However, vulnerable groups faced greater shocks and hardships during the COVID-19 pandemic. In addition, economic and demographic characteristics had a significant moderating effect.

Conclusions
This study showed a clear positive shift in public opinion about COVID-19, with this positive impact occurring primarily after stay-at-home orders. However, this positive sentiment is time-limited, with 14 days later allowing people to be more influenced by the status quo and trends, so feedback on the stay-at-home orders is no longer positively significant. In particular, negative sentiment is more likely to be generated in states with a large proportion of vulnerable groups, and the policy plays a limited role. The pandemic hit older people, those with underlying diseases, and small and medium enterprises directly but hurt states with cross-cutting economic situations and more complex demographics over time. Based on large-scale Twitter data, this sociological perspective allows us to monitor the evolution of public opinion more directly, assess the impact of social events on public opinion, and understand the heterogeneity in the face of pandemic shocks.