bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH FAKTOR SOSIAL DAN ETIKA DALAM PERILAKU PENGAMBILAN KEPUTUSAN INVESTASI: STUDI KASUS PADA INVESTASI KEUANGAN SYARIAH
Authors: Hamizar Arizal 
Published: September 2023

AbstractThis study examines how ethical and social responsibility factors influence investment decision-making among Islamic finance investors. Utilizing a qualitative approach, an analysis of investors' perceptions and preferences regarding investment is conducted, connecting them with the principles of Islamic finance. The results of in-depth interviews with a diverse group of investors reveal that the principles of Islamic finance serve as a strong ethical guide in investment decision-making. Moreover, it is found that ethical and social responsibility values are increasingly playing a significant role in guiding the selection of investment instruments. The importance of ethics in Islamic finance investment is reflected in investors' emphasis on the principles of Islamic finance that prohibit usury, ambiguity, and gambling. However, the findings also uncover that investors are increasingly considering the social impact of their investments. Social responsibility is deemed a determinant factor in decision-making, with preferences tending to shift towards investment instruments that provide positive benefits to society and the environment.Keywords: Financial Investment, Islamic Finance, Consumer Behavior, Social, Ethics. AbstrakPenelitian ini mengkaji bagaimana faktor etika dan tanggung jawab sosial mempengaruhi pengambilan keputusan investasi di kalangan investor keuangan syariah. Dengan menggunakan pendekatan kualitatif, analisis mengenai persepsi dan preferensi investasi para investor dilakukan, serta menghubungkannya dengan prinsip-prinsip keuangan syariah. Hasil wawancara mendalam dengan beragam investor mengungkapkan bahwa prinsip-prinsip keuangan syariah menjadi panduan etika yang kuat dalam pengambilan keputusan investasi. Selain itu, ditemukan nilai-nilai etika dan tanggung jawab sosial semakin memainkan peran yang signifikan dalam memandu pemilihan instrumen investasi. Pentingnya etika dalam investasi keuangan syariah tercermin dalam penekanan investor terhadap prinsip-prinsip keuangan syariah yang melarang riba, gharar, dan maisir. Namun, temuan juga mengungkapkan bahwa investor semakin mempertimbangkan dampak sosial dari investasi mereka. Tanggung jawab sosial dianggap sebagai faktor penentu dalam pengambilan keputusan, dengan preferensi yang cenderung beralih ke instrumen investasi yang memberikan manfaat positif bagi masyarakat dan lingkungan.Kata Kunci: Investasi Keuangan, keuangan Syariah, Perilaku Konsumen, Sosial, Etika.
Pemodelan Regresi Linear Berganda Pada Penyakit Demam Berdarah Dengue di Provinsi Daerah Khusus Ibukota Jakarta
Authors: Kurniawaty Rina , Baginda Edward Siagian  
Published: September 2023

Demam Berdarah Dengue merupakan penyakit yang ditularkan dari gigitan nyamuk Aedes Aegypti. Dalam kurun waktu 5 tahun terakhir di Indonesia, kasus dan kematian tertinggi terjadi pada tahun 2019. Dengan jumlah penderita Demam Berdarah Dengue (DBD) mencapai 138.127 dengan Case Fatality Rate (CFR) sebesar 0,67 dan jumlah penderita DBD yang meninggal sebanyak 919 orang. DKI Jakarta merupakan salah satu provinsi yang penduduknya banyak menderita penyakit DBD. Di tahun 2019 penderita DBD di Provinsi DKI Jakarta tercatat sebanyak 648 orang. Penyakit DBD dapat disebabkan oleh faktor yang beragam. Demam Berdarah disebabkan dengan berbagai faktor, salah satu metode yang dapat digunakan dalam hal ini regresi linear berganda Tujuan dari penelitian ini adalah menentukan model regresi linear berganda dan untuk mengetahui semua faktor yang mempengaruhi penyebaran DBD DKI Jakarta. Regresi linear berganda adalah Teknik statistika yang menjelaskan hubungan antara dua atau lebih variabel. Penelitian ini menggunakan variable yaitu banyaknya pasien DBD, curah hujan, kelembapan udara, dan suhu udara. Data DBD yang digunakan berasal dari data dinas Kesehatan DKI Jakarta dan data cuaca diperoleh dari BPS DKI Jakarta. Hasil perhitungan diperoleh koefisien dari determinasi adalah 79% yang berarti kontribusi variabel bebas terhadap penyebaran DBD di DKI Jakarta 79%, sedangkan sisanya 21% dijelaskan oleh faktor lain.
Fluid flow shear stress and tissue remodeling—an orthodontic perspective: evidence synthesis and differential gene expression network analysis
Authors: Nile Mustafa , Folwaczny Matthias , Wichelhaus Andrea , Baumert Uwe , Janjic Rankovic Mila 
Published: September 2023

Introduction: This study aimed to identify and analyze in vitro studies investigating the biological effect of fluid-flow shear stress (FSS) on cells found in the periodontal ligament and bone tissue.Method: We followed the PRISMA guideline for systematic reviews. A PubMed search strategy was developed, studies were selected according to predefined eligibility criteria, and the risk of bias was assessed. Relevant data related to cell source, applied FSS, and locus-specific expression were extracted. Based on this evidence synthesis and, as an original part of this work, analysis of differential gene expression using over-representation and network-analysis was performed. Five relevant publicly available gene expression datasets were analyzed using gene set enrichment analysis (GSEA).Result: A total of 6,974 articles were identified. Titles and abstracts were screened, and 218 articles were selected for full-text assessment. Finally, 120 articles were included in this study. Sample size determination and statistical analysis related to methodological quality and the ethical statement item in reporting quality were most frequently identified as high risk of bias. The analyzed studies mostly used custom-made fluid-flow apparatuses (61.7%). FSS was most frequently applied for 0.5 h, 1 h, or 2 h, whereas FSS magnitudes ranged from 6 to 20 dyn/cm2 depending on cell type and flow profile. Fluid-flow frequencies of 1 Hz in human cells and 1 and 5 Hz in mouse cells were mostly applied. FSS upregulated genes/metabolites responsible for tissue formation (AKT1, alkaline phosphatase, BGLAP, BMP2, Ca2+, COL1A1, CTNNB1, GJA1, MAPK1/MAPK3, PDPN, RUNX2, SPP1, TNFRSF11B, VEGFA, WNT3A) and inflammation (nitric oxide, PGE-2, PGI-2, PTGS1, PTGS2). Protein-protein interaction networks were constructed and analyzed using over-representation analysis and GSEA to identify shared signaling pathways.Conclusion: To our knowledge, this is the first review giving a comprehensive overview and discussion of methodological technical details regarding fluid flow application in 2D cell culture in vitro experimental conditions. Therefore, it is not only providing valuable information about cellular molecular events and their quantitative and qualitative analysis, but also confirming the reproducibility of previously published results.
Unveiling drug-tolerant and persister-like cells in Leishmania braziliensis lines derived from patients with cutaneous leishmaniasis
Authors: Jara Marlene , Arevalo Jorge , Llanos-Cuentas Alejandro , Broeck Frederik Van den , Domagalska Malgorzata Anna , Dujardin Jean-Claude 
Published: September 2023

IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications. However, microorganisms can also survive lethal drug exposure by entering into temporary quiescence, a phenomenon called drug tolerance (DT), which is rather unexplored in Leishmania.MethodsWe studied a panel of nine Leishmania braziliensis strains highly susceptible to potassium antimonyl tartrate (PAT), exposed promastigotes to lethal PAT pressure, and compared several cellular and molecular parameters distinguishing DT from DR.Results and discussionWe demonstrated in vitro that a variable proportion of cells remained viable, showing all the criteria of DT and not of DR: i) signatures of quiescence, under drug pressure: reduced proliferation and significant decrease of rDNA transcription; ii) reversibility of the phenotype: return to low IC50 after removal of drug pressure; and iii) absence of significant genetic differences between exposed and unexposed lineages of each strain and absence of reported markers of DR. We found different levels of quiescence and DT among the different L. braziliensis strains. We provide here a new in-vitro model of drug-induced quiescence and DT in Leishmania. Research should be extended in vivo, but the current model could be further exploited to support R&amp;D, for instance, to guide the screening of compounds to overcome the quiescence resilience of the parasite, thereby improving the therapy of leishmaniasis.
The Aswan Rheumatic heart disease reGIstry: rationale and preliminary results of the ARGI database
Authors: Kotit Susy , Yacoub Magdi H. 
Published: September 2023

BackgroundRheumatic Heart Disease (RHD) remains a major cause of valvular heart disease related mortality and morbidity in low- and middle-income countries, with significant variation in characteristics and course of the disease across different regions. However, despite the high disease burden, there is sparse region-specific data on demographics, disease characteristics and course in treated and untreated patients to guide policy.MethodsThe ARGI database is a hospital-based registry in a tertiary referral national centre (Aswan Heart Centre, AHC) in which all patients with the diagnosis of RHD are being included. The mode of presentation, including baseline clinical and echocardiographic characteristics (as well as other imaging modalities), biomarkers and genetics are being documented. Treatment modalities and adherence to treatment is being recorded and patients are followed up regularly every 6 and/or 12 months, or more frequently if needed.DiscussionThis study shows for the first time an in-depth analysis of the severity and phenotype of disease in Egyptian patients presenting with RHD as well as the progression with time and provides a platform for further comparisons of regional differences in these details as well as their causes. The ARGI database will be of help in achieving the objectives of the Cairo Accord aiming at eradication of RF and RHD.
Optimization of the lightning warning model for distribution network lines based on multiple meteorological factor thresholds
Authors: Wan Ziyang , Fu Lixiang , Pu Ziheng , Du Zhenchuan , Chen Zhigang , Zhu Yi , Ma Xiaoxin 
Published: September 2023

Lightning is one of the frequent natural disasters, which seriously affects the secure and stable operation of the power system, especially the distribution network lines with weak reliability. In order to improve the power supply reliability of the distribution network, higher requirements are put forward for the accuracy of lightning warning. Therefore, this paper establishes a lightning warning model based on comprehensive multi-meteorological factor thresholds and analyzes the meteorological factor data such as atmospheric field strength, echo intensity, echo-top height, and vertical cumulative liquid water content under thunderstorm weather. The threshold value of each factor warning is obtained, and the corresponding threshold weight is calculated by the entropy weight method. According to the weight of each threshold, the comprehensive threshold index of lightning warning is obtained, and the lightning warning is based on this index. A total of 105 lightning data from May to June 2022 in Nanchang city were analyzed as samples. The thresholds of atmospheric field strength, echo intensity, echo-top height, and vertical cumulative liquid water content were 1.2 kV/m, 40 dBZ, 8 km, and 5.2 kg·m−2, respectively. The corresponding weights of each factor were 0.4188, 0.2056, 0.2105, and 0.165, respectively. This model was used to warn a thunderstorm event in July 2022 in Nanchang area. The success rate of the model warning was 0.91, the false alarm rate (FAR) was 0.11, and the critical success index (CSI) was 0.80. Compared with the single-factor threshold lightning warning model, the warning FAR is decreased by 6%, and CSI is increased by 14% while ensuring the high warning success rate.
Utilization of preconception care and associated factors among pregnant mothers in Fiche Town, Central Ethiopia: a community-based cross-sectional study 2021
Authors: Fetena Negash , Negash Abraham , Kebede Alemi , Sertsu Addisu , Nega Addisu , Nigussie Kabtamu , Lami Magarsa , Yadeta Elias , Dereje Jerman , Tamire Aklilu , Tolessa Fikadu , Tadele Afework 
Published: September 2023

IntroductionPreconception care is an important preventive intervention for adverse pregnancy outcomes. It is recognized as a strategy to optimize women's health and pregnancy outcomes in Western countries. However, preconception care is underutilized in sub-Saharan Africa, like Ethiopia, where maternal mortality is high. Evidence is scarce in the study area about the prevalence and factors associated with preconception care utilization. Therefore this study aimed to assess the proportion of preconception care utilization and associated factors among pregnant mothers in Fiche town, central Ethiopia, 2021.MethodA community-based cross-sectional study was done from May 10 to June 25, 2021. A systematic random sample technique was used to choose 393 pregnant women for the study. A structured, pre-tested, interviewer-administered questionnaire was used to collect data. The data were entered into Epi Data version 3.1 and then exported into SPSS version 25 for analysis. A Bivariable and multivariable logistic regression analysis was used to check for the association. Odds ratio along with 95% was used to describe the association. Finally, a significant association was declared at a p-value less than 0.05.Results388 respondents participated in this study, making the response rate 98.7%. Of total study participants only 84 (21.6%; 95% CI, 18, 25.8) utilized preconception care. The study found that diploma or higher level of education (AOR = 3.47, 95% CI: 1.27, 9.53), psychological and financial support from a partner (AOR = 3.86, 95% CI: 2.1, 7.10), joint discussion and plan with a partner (AOR = 3.32, 95% CI: 1.55, 7.13), history of chronic disease (AOR = 3.47, 95% CI: 1.67, 7.25), and good knowledge about preconception care (AOR = 2.42, 95% CI: 1.34, 4.38) were significantly associated with preconception care utilization.ConclusionsOverall, less than a quarter of the pregnant mothers utilized preconception care, indicating that awareness is very low. Pregnant mothers who have a higher educational level, have good communication and support from their partners, have chronic health problems, and have good knowledge about preconception care were more likely to utilize the service. Preconception care is a better opportunity to intervene and maintain the mother in the continuum of care.
Efficacy and safety of immunotherapy combined with single-agent chemotherapy as second- or later-line therapy for metastatic non-small cell lung cancer
Authors: Chen Dongna , Li Lin , Wang Mingzhao , Hu Xingsheng , Jiang Jun , Li Weihua , Yang Lin , Fan Meng , Shi Yuankai , Lv Fang , Liu Yutao 
Published: September 2023

ObjectiveThis study sought to assess the efficacy and safety of immunotherapy combined with single-agent chemotherapy as a second- or later-line setting for metastatic non-small cell lung cancer (NSCLC) and to provide clinical evidence for this treatment regimen. The predictive value of extracellular vesicle (EV) membrane proteins was explored in patients who underwent this treatment.MethodsClinical data from patients diagnosed with metastatic NSCLC who received immunotherapy plus single-agent chemotherapy as a second- or later-line setting were retrospectively collected between March 2019 and January 2022. A total of 30 patients met the inclusion criteria, and all were pathologically confirmed to have NSCLC. Short-term efficacy, progression-free survival (PFS), EV markers for response prediction, and adverse events were assessed.ResultsEfficacy data were available for all 30 patients and included a partial response in 5 patients, stable disease in 18 patients, and disease progression in 7 patients. The objective response rate was 16.7%, the disease control rate was 76.7%, and the median PFS was 3.2 months. Univariate analysis showed that PFS was not associated with sex, age, smoking status, treatment lines, prior use of immunotherapy, or prior use of antiangiogenic drugs. The EV membrane proteins MET proto-oncogene, receptor tyrosine kinase (c-MET), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor receptor 2 (VEGFR2) at baseline were associated with poor prognosis and correlated with the efficacy of immunotherapy plus chemotherapy. According to the receiver operating characteristics and Kaplan–Meier curve analyses, patients with high c-MET, EGFR, and VEGFR2 expression at baseline had significantly shorter PFS than those with low expression. In addition, VEGFR2 expression was increased after combined immunotherapy in responders, which was decreased in non-responders. The most common grade 2 or higher adverse events were neutropenia, gastrointestinal reactions, and thyroid dysfunction, all of which were tolerated.ConclusionsImmunotherapy plus single-agent chemotherapy as a second- or later-line treatment is safe, effective, and tolerable for metastatic NSCLC. EV markers can be used as predictive markers of efficacy in patients with metastatic NSCLC treated with immunotherapy plus chemotherapy to help monitor treatment efficacy and guide treatment decisions.
Shared bias in H chain V-J pairing in naive and memory B cells
Authors: Levi Reut , Dvorkin Shirit , Louzoun Yoram 
Published: September 2023

IntroductionH chain rearrangement in B cells is a two-step process where first DH binds JH, and only then VH is joined to the complex. As such, there is no direct rearrangement between VH and JH.ResultsNevertheless, we here show that the VHJH combinations frequency in humans deviates from the one expected based on each gene usage frequency. This bias is observed mainly in functional rearrangements, and much less in out-of-frame rearrangements. The bias cannot be explained by preferred binding for DH genes or a preferred reading frame. Preferred VH
JH combinations are shared between donors.DiscussionThese results suggest a common structural mechanism for these biases. Through development, thepreferred VH
JH combinations evolve during peripheral selection to become stronger, but less shared. We propose that peripheral Heavy chain VH
JH usage is initially shaped by a structural selection before the naive B cellstate, followed by pathogen-induced selection for host specific VH-JH pairs.
Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection
Authors: Zec Kristina , Thiebes Stephanie , Bottek Jenny , Siemes Devon , Spangenberg Philippa , Trieu Duc Viet , Kirstein Nils , Subramaniam Nirojah , Christ Robin , Klein Diana , Jendrossek Verena , Loose Maria , Wagenlehner Florian , Jablonska Jadwiga , Bracht Thilo , Sitek Barbara , Budeus Bettina , Klein-Hitpass Ludger , Theegarten Dirk , Shevchuk Olga , Engel Daniel R. 
Published: September 2023

IntroductionStreptococcus pneumoniae is one of the main causes of community-acquired infections in the lung alveoli in children and the elderly. Alveolar macrophages (AM) patrol alveoli in homeostasis and under infectious conditions. However, the molecular adaptations of AM upon infections with Streptococcus pneumoniae are incompletely resolved.MethodsWe used a comparative transcriptomic and proteomic approach to provide novel insights into the cellular mechanism that changes the molecular signature of AM during lung infections. Using a tandem mass spectrometry approach to murine cell-sorted AM, we revealed significant proteomic changes upon lung infection with Streptococcus pneumoniae.ResultsAM showed a strong neutrophil-associated proteomic signature, such as expression of CD11b, MPO, neutrophil gelatinases, and elastases, which was associated with phagocytosis of recruited neutrophils. Transcriptomic analysis indicated intrinsic expression of CD11b by AM. Moreover, comparative transcriptomic and proteomic profiling identified CD11b as the central molecular hub in AM, which influenced neutrophil recruitment, activation, and migration.DiscussionIn conclusion, our study provides novel insights into the intrinsic molecular adaptations of AM upon lung infection with Streptococcus pneumoniae and reveals profound alterations critical for effective antimicrobial immunity.
Single-cell sequencing of tumor-associated macrophages in a Drosophila model
Authors: Khalili Dilan , Mohammed Mubasher , Kunc Martin , Sindlerova Martina , Ankarklev Johan , Theopold Ulrich 
Published: September 2023

IntroductionTumor-associated macrophages may act to either limit or promote tumor growth, yet the molecular basis for either path is poorly characterized.MethodsWe use a larval Drosophila model that expresses a dominant-active version of the Ras-oncogene (RasV12) to study dysplastic growth during early tumor progression. We performed single-cell RNA-sequencing of macrophage-like hemocytes to characterize these cells in tumor- compared to wild-type larvae. Hemocytes included manually extracted tumor-associated- and circulating cells.Results and discussionWe identified five distinct hemocyte clusters. In addition to RasV12 larvae, we included a tumor model where the activation of effector caspases was inhibited, mimicking an apoptosis-resistant setting. Circulating hemocytes from both tumor models differ qualitatively from control wild-type cells—they display an enrichment for genes involved in cell division, which was confirmed using proliferation assays. Split analysis of the tumor models further reveals that proliferation is strongest in the caspase-deficient setting. Similarly, depending on the tumor model, hemocytes that attach to tumors activate different sets of immune effectors—antimicrobial peptides dominate the response against the tumor alone, while caspase inhibition induces a shift toward members of proteolytic cascades. Finally, we provide evidence for transcript transfer between hemocytes and possibly other tissues. Taken together, our data support the usefulness of Drosophila to study the response against tumors at the organismic level.