bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the inferior vena cava collapsibility from subcostal and trans-hepatic imaging using both M-mode or artificial intelligence: a prospective study on healthy volunteers
Authors: Sanfilippo Filippo , La Via Luigi , Dezio Veronica , Santonocito Cristina , Amelio Paolo , Genoese Giulio , Astuto Marinella , Noto Alberto 
Published: April 2023

Abstract
Purpose
Assessment of the inferior vena cava (IVC) respiratory variation may be clinically useful for the estimation of fluid-responsiveness and venous congestion; however, imaging from subcostal (SC, sagittal) region is not always feasible. It is unclear if coronal trans-hepatic (TH) IVC imaging provides interchangeable results. The use of artificial intelligence (AI) with automated border tracking may be helpful as part of point-of-care ultrasound but it needs validation.

Methods
Prospective observational study conducted in spontaneously breathing healthy volunteers with assessment of IVC collapsibility (IVCc) in SC and TH imaging, with measures taken in M-mode or with AI software. We calculated mean bias and limits of agreement (LoA), and the intra-class correlation (ICC) coefficient with their 95% confidence intervals.

Results
Sixty volunteers were included; IVC was not visualized in five of them (n = 2, both SC and TH windows, 3.3%; n = 3 in TH approach, 5%). Compared with M-mode, AI showed good accuracy both for SC (IVCc: bias − 0.7%, LoA [− 24.9; 23.6]) and TH approach (IVCc: bias 3.7%, LoA [− 14.9; 22.3]). The ICC coefficients showed moderate reliability: 0.57 [0.36; 0.73] in SC, and 0.72 [0.55; 0.83] in TH. Comparing anatomical sites (SC vs TH), results produced by M-mode were not interchangeable (IVCc: bias 13.9%, LoA [− 18.1; 45.8]). When this evaluation was performed with AI, such difference became smaller: IVCc bias 7.7%, LoA [− 19.2; 34.6]. The correlation between SC and TH assessments was poor for M-mode (ICC = 0.08 [− 0.18; 0.34]) while moderate for AI (ICC = 0.69 [0.52; 0.81]).

Conclusions
The use of AI shows good accuracy when compared with the traditional M-mode IVC assessment, both for SC and TH imaging. Although AI reduces differences between sagittal and coronal IVC measurements, results from these sites are not interchangeable.
Relationship between the shape of the elliptical knee joint and jumping height in a leg-type robot driven by pneumatic artificial muscle
Authors: Okumura Taichi , Nakanishi Daisuke , Naniwa Keisuke , Sugimoto Yasuhiro , Osuka Koichi 
Published: April 2023

AbstractThe McKibben pneumatic actuator (MPA) is a soft actuator used for performing various practical functions in robots. Particularly, many dynamic robots have been realized using MPAs. However, there is a trade-off between torque generated by MPA and the range of motion of the joint. In this study, we focus on the jumping motion of a leg-type robot and use an elliptical pulley whose moment arm changes depending on the robot’s posture. To confirm the effectiveness of the elliptical pulley, the relationship between the knee joint pulley (patella) shape and jumping height was analyzed by simulation, and the shape of the patella maximizing jumping height was determined. It was shown that an elongated elliptical patella shape is more effective for the jumping motion than a circular one. Furthermore, the effectiveness of the analytically determined patella shape was confirmed by experiments using an actual robot.
Design of the contingent royalty rate as related to the type of investment
Authors: Jou Jyh-Bang , Lee Charlene Tan 
Published: April 2023

AbstractThis study investigates the design of the royalty rate in a first-price auction across three types of investments: incremental and lumpy with or without an exogenously given intensity. A bidder’s investment cost comprises private information. This, together with the stochastic evolution of the price of the output generated from the auctioned project, precludes the seller from setting the exact dates of investment with the winner. However, the seller can set the royalty rate to equate the winner’s royalty payment with the winner’s information rent so that the winner acts as if to maximize the seller’s revenue. We derive two main conclusions. First, compared with the case in which investment is lumpy with an exogenously given intensity, the seller can set a lower royalty rate on incremental investment because she can collect additional royalty payments from the winner, who has the option to later expand capacity. Second, the impact of output price uncertainty on the optimal royalty rate for the three types of investments exhibits two different patterns. When investment is either incremental or lumpy with an exogenously given intensity, greater output price uncertainty reduces the royalty rate. When investment is lumpy with variable intensity, greater output uncertainty raises the royalty rate. Our results imply that auctioneers may charge differential royalty rates for different types of investments.
Feasibility of aortic aneurysm sac embolization using a novel shape memory polymer embolic device
Authors: Massmann Alexander , Fries Peter , Shayesteh-Kheslat Roushanak , Buecker Arno , Berg Patrick , Frenzel Felix 
Published: April 2023

Abstract

Background
We investigated the feasibility of aneurysm sac embolization using a novel self-expanding porous shape memory polymer (SMP) device during endovascular aortic abdominal or thoracic aneurysm repair (EVAR).

Methods
Retrospective analysis of consecutive patients treated at 2 centers in Germany. Patients were treated from January 2019 to July 2021 with follow-up at 7 days and 3, 6, and 12 months. Aneurysm sacs were implanted with SMP devices immediately following endograft placement during the same procedure. Primary endpoint was technically successful SMP-device deployment into the aneurysm sac outside the endograft. Secondary endpoints were changes in aneurysm volume and associated complications (e.g., endoleaks).

Results
We included 18 patients (16 males), aged 72 ± 9 years, achieving 100% technical success. Mean preprocedure aortic aneurysm sac volume was 195 ± 117 mL with a perfused aneurysm volume of 97 ± 60 mL. A mean of 24 ± 12 SMP devices per patient were used (range 5–45, corresponding to 6.25–56.25 mL expanded embolic material volume). All evaluable patients exhibited sac regression except 2 patients yet to reach 3-month follow-up. At mean 11 ± 7 months (range 3–24), change in aneurysm volume from baseline was -30 ± 21 mL (p < 0.001). In 8 patients, aneurysm regression was observed despite type 2 endoleaks in 6 and type 1A endoleaks in 2, none of them requiring further intervention to date. No morbidity or mortality related to this treatment occurred.

Conclusions
SMP devices for aortic aneurysm sac embolization during endovascular repair appear feasible and safe in this small case series. Prospective studies are needed.

Key points
• Shape memory polymer is a novel, self-expanding, porous, and radiolucent embolic device material.
• Aortic aneurysm sacs were treated with polymer devices immediately following endograft placement.
• Aortic aneurysm sac regression was observed in all patients with over 3-month follow-up.
• Aortic aneurysm sac regression was observed even in the presence of endoleaks.
Interventional non-operative management of low back and neck pain
Authors: Alkosha Hazem M. 
Published: April 2023

Abstract
Background
Chronic neck and back pain are among the most commonly encountered health problems in neurosurgical practice. Many cases fail prolonged pharmacological and physical therapy and are not proper candidates for surgical interventions, or had refused proposed surgical treatment.

Objective
To provide an informative critical summary of the literature about the topic of interventional management of axial neck and low back pain and highlighting the new trends and pieces of evidence.

Methods
The English literature published over the last two decades was reviewed by the author for recent and relevant data about the principles of interventional management of chronic neck and low back pain. A PubMed search was performed through phrase searching and combined searching using Boolean operators. The articles thought to be most relevant to the study aim and the neurosurgeons’ practice were extracted.

Results
Neck and low back pain continue to be among the most common musculoskeletal health problems and the most common cause of disability worldwide. A detailed understanding of relevant spine anatomy is crucial for interventionists who should deal with the concept of “functional spine unit” with multiple potential pain generators. Chronic spinal pain is best managed through a dedicated multidisciplinary team in well-equipped healthcare facilities. An algorithmic approach for the diagnosis and management of spinal pain is the mainstay of providing the best patient care and should be based on the commonality and treatability of pain generators, values of patients and available resources.

Conclusion
Management of chronic neck and back pain can represent a clinical dilemma due to the multiplicity of pain generators that may coexist in the same individual resulting in a complex type and pattern of pain. Approach to these patients requires contributions from the members of a multidisciplinary team, implementing a standardized approach in a well-equipped healthcare facility.
Jeu de mots paronomasia: a StackOverflow-driven bug discovery approach
Authors: Yang Yi , Li Ying , Chen Kai , Liu Jinghua 
Published: April 2023

AbstractLocating bug code snippets (short for BugCode) has been a complex problem throughout the history of software security, mainly because the constraints that define BugCode are obscure and hard to summarize. Previously, security analysts attempted to define such constraints manually (e.g., limiting buffer size to detect overflow), but were limited to the types of BugCode. Recent researchers address this problem by extracting constraints from program documentation, which shows the potential for API misuse. But for bugs beyond the scope of API misuse, such an approach becomes less effective since the corresponding constraints are not defined in documents, not to mention the programs without documentation In this paper, inspired by the fact that expert programmers often correct the BugCode on open forums such as StackOverflow, we design an approach to automatically extract knowledge from StackOverflow and leverage it to detect BugCode. As we all know, the contexts in StackOverflow come from ordinary developers. Their writing tends to be loosely organized and in various styles, which are more challenging to analyze than program documentation. To address the challenges, we design a custom tokenization approach to segment sentences and employ sentiment analysis to find the Controversial Sentences (CSs) that typically contain the constraints we need for code analysis. Then we use constituency parsing to extract knowledge from CSs, which helps locate BugCode. We evaluated our system on 41,144 comments from the questions tagged with Java and Android. The results show that our approach achieves 95.5% precision in discovering CSs. We have discovered 276 pieces of BugCode proved to be true through manual validation including an assigned CVE. 89.3% of the discovered bugs remained in the current version of answers, which are unknown to users.
Risk factors for pain after total hip arthroplasty: a systematic review
Authors: Zhang Bo , Rao Sandesh , Mekkawy Kevin L. , Rahman Rafa , Sarfraz Anzar , Hollifield Lauren , Runge Nick , Oni Julius K. 
Published: April 2023

Abstract
Background
Approximately 23% of patients develop hip pain after total hip arthroplasty (THA). In this systematic review, we aimed to identify risk factors associated with postoperative pain after THA to optimize preoperative surgical planning.

Methods
Six literature databases were searched for articles published from January 1995 to August 2020. Controlled trials and observational studies that reported measurements of postoperative pain with assessments of preoperative modifiable and non-modifiable risk factors were included. Three researchers performed a literature review independently.

Results
Fifty-four studies were included in the study for analysis. The most consistent association between worse pain outcomes and the female sex is poor preoperative pain or function, and more severe medical or psychiatric comorbidities. The correlation was less strong between worse pain outcomes and preoperative high body mass index value, low radiographic grade arthritis, and low socioeconomic status. A weak correlation was found between age and worse pain outcomes.

Conclusions
Preoperative risk factors that were consistently predictive of greater/server postoperative pain after THA were identified, despite the varying quality of studies that prohibited the arrival of concrete conclusions. Modifiable factors should be optimized preoperatively, whereas non-modifiable factors may be valuable to patient education, shared decision-making, and individualized pain management.
Plant-based traditional foods and beverages of Gumare Village, Botswana
Authors: Tselaesele Nelson , Bultosa Geremew , Molapisi Moenyane , Makhabu Shimane , Kobue-Lekalake Rosemary , Haki Gulelat Desse , Sekwati-Monang Bonno , Seifu Eyassu , Mokhawa Gaone , Sonno Kethabile 
Published: April 2023

AbstractThe consumption of traditional and indigenous foods and beverages varies across different ethnic communities and is often influenced by geographical location. However, the diversity of edible plants is rapidly declining due to climate change, leading to a loss of knowledge about useful plants used by different communities before the plant itself becomes extinct. This research investigated the edible plant types and investigated the processing steps of plant-based traditional foods/dishes and beverages of Gumare village, located in the catchment area of the Okavango Delta in the northwest of Botswana. Questionnaire interviews and focus group discussions (FGD) were used to collect data. The study identified 52 wild and 19 domesticated edible plants used in the preparation of traditional foods/dishes and beverages of Gumare village. Maize, sorghum, millets, beans, melon, watermelon, pumpkin, bottle gourd and sweet potato are widely used domesticated crops. The wild edible plants are either directly used after minor processing or as recipes in traditional dishes and/or as an inoculum in the fermentation, as a substrate in traditional beverages and some as medicinal plants. However, some taboos and food safety challenges were observed in the use of certain plants. The study highlighted a decline in the use of traditional foods/dishes and beverages, particularly among the young generation. The youth indicated that they have a low interest in gathering traditional foods and beverages due to the time-consuming nature during harvesting and the labour-intensive processing. In addition, they indicated the dangers of attacks by wild animals from veld by reptiles (for example snakes and pythons) and alligators (crocodiles) from rivers during the harvesting of raw materials used in traditional foods and dishes. For the communities, the diverse edible wild plants documented are a source of nutrients and bioactive compounds such as dietary fibers, phenolics, terpenes, essential oils, carotenoids, and alkaloids that help to combat malnutrition and for use as traditional medicines to support health and wellness. In conclusion, the significant diversity of wild edible plants and domesticated crops in Gumare village, likely due to its location in the catchment area of the Okavango Delta, plays a crucial role in diet diversification and can contribute to food and nutrition security. However, for most wild edible plants of Botswana, information on their nutrient and bioactive compounds are still limited. This study provides baseline information for further chemical investigation and development of resources in the formulation of functional foods and nutraceuticals.Graphical Abstract
Molecular patterns of egyptian patients with non-squamous non-small-cell lung cancers: a clinicopathological study
Authors: Ismail Mohamed Said , Kassem Loay , Ali Ahmed Al-Husseiny , Ahmed Fatma Elzahraa , Shalaby Mohamed , Magdy Sally 
Published: April 2023

Abstract
Background
Driver molecular aberrations, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement, play an important role in the oncogenesis and progression of non-squamous non-small-cell lung cancers (NSCLC). Therefore, this study aimed to detect the incidence of driver mutations among non-squamous NSCLC.

Patients and methods
This was a retrospective-prospective cohort study on 131 patients with non-squamous NSCLC. Data on age, smoking status, chest symptoms, method of lung cancer diagnosis, molecular testing, including EGFR mutations in formalin-fixed paraffin-embedded (FFPE) tumor tissue and serum circulating tumor DNA using next-generation sequencing and ALK gene rearrangement by FFPE tumor tissue, and follow-up data regarding treatment modalities and outcomes were collected.

Results
The median age of the patients was 57 years (range: 32–79 years). Out of 131 patients, 97 were males (74%), and 90 (68.7%) were smokers. Among 128 patients tested, 16 (12.5%) had EGFR mutations detected with either technique by formalin-fixed paraffin-embedded (FFPE) tumor tissue or/and serum circulating tumor DNA using next-generation sequencing, and 6 (4.7%) had ALK rearrangement by FFPE tumor tissue. The majority (62.6%) presented with metastatic disease. Among the 102 patients who received first-line systemic therapy, the objective response rate was 50.0% in mutated NSCLC versus 14.6% in non-mutated (p < 0.001). Among the eight mutated patients who received first-line tyrosine kinase inhibitors (TKIs), 7 patients achieved either complete response or partial response. Among the 22 mutated patients, the median overall survival was 3 months in those who did not receive targeted therapy versus not reached in those who received any type of targeted therapy (p < 0.001).

Conclusion
Screening patients with newly diagnosed non-squamous NSCLC for driver mutations is essential for major prognostic and therapeutic implications. Early administration of TKIs in mutated patients significantly improves disease outcomes.
Long-term use of colchicine: “The time to guard against chronic toxicity among patients of familial Mediterranean fever”
Authors: Emara Mohamed H. , Abdelkader Abeer Hussein , Radwan Mohamed Said , Elbatae Hassan E. , Saeed Maysaa A. 
Published: April 2023

Abstract
Colchicine is a cheap easily available and accessible drug that has been tried in different diseases which are not limited to gout, familial Mediterranean fever (FMF), Behcet’s disease, and constipation, and has recently been tried for the treatment of COVID-19 and heart diseases. There are many emerging reports of toxicity related to colchicine use. Patients with FMF are using this drug lifelong. We are sounding the alarm for monitoring patients with FMF to guard against chronic colchicine toxicity.
Three-dimensional nanoscale reduced-angle ptycho-tomographic imaging with deep learning (RAPID)
Authors: Wu Ziling , Kang Iksung , Yao Yudong , Jiang Yi , Deng Junjing , Klug Jeffrey , Vogt Stefan , Barbastathis George 
Published: April 2023

AbstractX-ray ptychographic tomography is a nondestructive method for three dimensional (3D) imaging with nanometer-sized resolvable features. The size of the volume that can be imaged is almost arbitrary, limited only by the penetration depth and the available scanning time. Here we present a method that rapidly accelerates the imaging operation over a given volume through acquiring a limited set of data via large angular reduction and compensating for the resulting ill-posedness through deeply learned priors. The proposed 3D reconstruction method “RAPID” relies initially on a subset of the object measured with the nominal number of required illumination angles and treats the reconstructions from the conventional two-step approach as ground truth. It is then trained to reproduce equal fidelity from much fewer angles. After training, it performs with similar fidelity on the hitherto unexamined portions of the object, previously not shown during training, with a limited set of acquisitions. In our experimental demonstration, the nominal number of angles was 349 and the reduced number of angles was 21, resulting in a $$\times 140$$

×
140

aggregate speedup over a volume of $$4.48\times 93.18\times 3.92\, \upmu \text {m}^3$$

4.48
×
93.18
×
3.92

μ

m
3

and with $$(14\,\text {nm})^3$$

(
14

nm
)

3

feature size, i.e. $$\sim 10^8$$

∼

10
8

voxels. RAPID’s key distinguishing feature over earlier attempts is the incorporation of atrous spatial pyramid pooling modules into the deep neural network framework in an anisotropic way. We found that adjusting the atrous rate improves reconstruction fidelity because it expands the convolutional kernels’ range to match the physics of multi-slice ptychography without significantly increasing the number of parameters.
Maternal and Infant Outcomes in GCK-MODY Complicated by Pregnancy
Authors: Ren Qian , Wang Zhihui , Yang Wenjia , Han Xueyao , Ji Linong 
Published: April 2023

Abstract

Context
Challenges exist in the management of Glucokinase–maturity-onset diabetes of the young (GCK-MODY), especially during pregnancy.

Objective
This work aimed to evaluate the prevalence of congenital anomaly in newborns from GCK-MODY mothers, and the relationship between fetus genotype and the risk of congenital malformation as well as other adverse pregnancy outcomes.

Methods
Electronic databases including PubMed, EMBASE, and Cochrane database last updated July 16, 2022, were searched. We included observational studies conducted in GCK-MODY complicated by pregnancy, and reporting at least one pregnancy outcome. We extracted data in duplicate, and the risk of bias was evaluated by the Newcastle-Ottawa Quality Assessment Scale (NOS). All statistical analysis was performed by Cochrane Review Manager.

Results
Eight studies were selected in the meta-analysis. Five were of high quality and 3 were of medium quality evaluated by NOS. A total of 257 GCK-MODY mothers and 499 offspring were enrolled. Among them, 370 offspring were divided into 2 groups: GCK-affected offspring (GCK+, n = 238) and GCK-unaffected offspring (GCK−, n = 132). The percentage of congenital malformations in GCK pregnant women's offspring was 2.4%. The risk of congenital malformations was similar between the GCK+ and GCK− group (odds ratio = 0.56; 95% CI, 0.07-4.51; I2 = 0%; P = .59). The risk of macrosomia/large for gestational age, neonatal hypoglycemia, and combined adverse neonatal outcome was significantly lower in offspring with the GCK mutation compared with non–GCK mutation carriers.

Conclusion
The percentage of congenital malformations was 2.4% in GCK-MODY pregnant women's offspring, and newborns with the GCK mutation have lower birth complication than non–GCK mutation carriers.