bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epistemological Cognition in Husserl
Authors: Larsen Tarjei Mandt 
Published: April 2023

Abstract
What degree of justification should be required of epistemological cognition, the kind of cognition by which epistemological problems are to be solved? I consider the question by examining Husserl’s view of the matter. Challenging the current consensus, I argue that he is committed to the infallibility of epistemological cognition. I first present what he takes to be the leading problem of epistemology, which he designates as the ‘problem of transcendence’ or the problem of how ‘transcendent cognition’ is possible. I then give an account of what I call his Non-Transcendence Constraint, on which the problem cannot be solved by means of cognitions of the kind whose possibility it concerns, and so cannot be solved by means of transcendent cognition. Pointing out that he provides four specifications of the problem, I go on to argue that on the most fundamental of these it concerns the general possibility of fallible cognition. By the Non-Transcendence Constraint, however, this entails that the problem of transcendence cannot be solved by means of fallible cognition. I conclude that central aspects of Husserl’s metaepistemology commit him to the infallibility of epistemological cognition, at least as far as solving the supposedly leading problem of epistemology is concerned.
The collapse of atomically cooled primordial haloes – I. High Lyman–Werner backgrounds
Authors: Patrick Samuel J , Whalen Daniel J , Latif Muhammed A , Elford Jacob S 
Published: April 2023

ABSTRACT
Pristine, atomically cooled haloes may be the sites of primordial quasar formation because atomic cooling triggers rapid baryon collapse that can create 104–105 M⊙ black hole seeds. However, no numerical simulation has ever followed the collapse of these haloes for the times required to form supermassive stars and direct-collapse black holes (DCBHs). We have now modelled baryon collapse in atomically cooled haloes with a wide range of spin parameters and assembly histories for times that are sufficient for DCBH formation. Fragmentation of accretion discs after ∼500 kyr is nearly ubiquitous in these haloes and in most cases leads to the formation of binary or multiple supermassive stellar systems. They also confirm that rapid baryon collapse proceeds for the times required for these stars to form DCBHs. Our simulations suggest that binary or even multiple DCBH formation was the rule rather than the exception in the primordial Universe.
The magnetic field and multiple planets of the young dwarf AU Mic
Authors: Donati J-F , Cristofari P I , Finociety B , Klein B , Moutou C , Gaidos E , Cadieux C , Artigau E , Correia A C M , Boué G , Cook N J , Carmona A , Lehmann L T , Bouvier J , Martioli E , Morin J , Fouqué P , Delfosse X , Doyon R , Hébrard G , Alencar S H P , Laskar J , Arnold L , Petit P , Kóspál Á , Vidotto A , Folsom C P , collaboration the S L S 
Published: April 2023

ABSTRACT
In this paper, we present an analysis of near-infrared spectropolarimetric and velocimetric data of the young M dwarf AU Mic, collected with SPIRou at the Canada–France–Hawaii telescope from 2019 to 2022, mostly within the SPIRou Legacy Survey. With these data, we study the large- and small-scale magnetic field of AU Mic, detected through the unpolarized and circularly polarized Zeeman signatures of spectral lines. We find that both are modulated with the stellar rotation period (4.86 d), and evolve on a time-scale of months under differential rotation and intrinsic variability. The small-scale field, estimated from the broadening of spectral lines, reaches 2.61 ± 0.05 kG. The large-scale field, inferred with Zeeman–Doppler imaging from Least-Squares Deconvolved profiles of circularly polarized and unpolarized spectral lines, is mostly poloidal and axisymmetric, with an average intensity of 550 ± 30 G. We also find that surface differential rotation, as derived from the large-scale field, is ≃30 per cent weaker than that of the Sun. We detect the radial velocity (RV) signatures of transiting planets b and c, although dwarfed by activity, and put an upper limit on that of candidate planet d, putatively causing the transit-timing variations of b and c. We also report the detection of the RV signature of a new candidate planet (e) orbiting further out with a period of 33.39 ± 0.10 d, i.e. near the 4:1 resonance with b. The RV signature of e is detected at 6.5σ while those of b and c show up at ≃4σ, yielding masses of $10.2^{+3.9}_{-2.7}$ and $14.2^{+4.8}_{-3.5}$ M⊕ for b and c, and a minimum mass of $35.2^{+6.7}_{-5.4}$ M⊕ for e.
RNA fusion transcript panel identifies diverse repertoire of fusions in adult glioma patients with therapeutic implications
Authors: Kothari Shawn , Dusenbery Anna C , Doucette Abigail , Zhang Daniel Y , Ballinger Dominique , Desai Arati , Morrissette Jennifer J D , Bagley Stephen J , Nasrallah MacLean P 
Published: April 2023

Abstract

Background
Recurrent gliomas are therapeutically challenging diseases with few treatment options available. One area of potential therapeutic vulnerability is the presence of targetable oncogenic fusion proteins.

Methods
To better understand the clinical benefit of routinely testing for fusion proteins in adult glioma patients, we performed a retrospective review of 647 adult patients with glioma who underwent surgical resection at our center between August 2017 and May 2021 and whose tumors were analyzed with an in-house fusion transcript panel.

Results
Fifty-two patients (8%) were found to harbor a potentially targetable fusion with 11 (21%) of these patients receiving treatment with a fusion-targeted inhibitor. The targetable genes found to be involved in a fusion included FGFR3, MET, EGFR, NTRK1, NTRK2, BRAF, ROS1, and PIK3CA.

Conclusions
This analysis demonstrates that routine clinical testing for gene fusions identifies a diverse repertoire of potential therapeutic targets in adult patients with glioma and can offer rational therapeutic options for patients with recurrent disease.
Non-centrosymmetric topological phase probed by non-linear Hall effect
Authors: Wang Naizhou , You Jing-Yang , Wang Aifeng , Zhou Xiaoyuan , Zhang Zhaowei , Lai Shen , Feng Yuan-Ping , Lin Hsin , Chang Guoqing , Gao Wei-bo 
Published: April 2023

Abstract
Non-centrosymmetric topological material has attracted intense attention due to its superior characteristics as compared with the centrosymmetric one, although probing the local quantum geometry in non-centrosymmetric topological material remains challenging. The non-linear Hall (NLH) effect provides an ideal tool to investigate the local quantum geometry. Here, we report a non-centrosymmetric topological phase in ZrTe5, probed by using the NLH effect. The angle-resolved and temperature-dependent NLH measurement reveals the inversion and ab-plane mirror symmetries breaking at &lt;30 K, consistently with our theoretical calculation. Our findings identify a new non-centrosymmetric phase of ZrTe5 and provide a platform to probe and control local quantum geometry via crystal symmetries.
The heterogeneity–diversity–system performance nexus
Authors: Eisenhauer Nico , Angst Gerrit , Asato Ana E B , Beugnon Rémy , Bönisch Elisabeth , Cesarz Simone , Dietrich Peter , Jurburg Stephanie D , Madaj Anna-Maria , Reuben Rine C , Ristok Christian , Sünnemann Marie , Yi Huimin , Guerra Carlos A , Hines Jes 
Published: April 2023

ABSTRACT
Ever-growing human population and nutritional demands, supply chain disruptions, and advancing climate change have led to the realization that changes in diversity and system performance are intimately linked. Moreover, diversity and system performance depend on heterogeneity. Mitigating changes in system performance and promoting sustainable living conditions requires transformative decisions. Here, we introduce the heterogeneity–diversity–system performance (HDP) nexus as the conceptual basis upon which to formulate transformative decisions. We suggest that managing the heterogeneity of systems will best allow diversity to provide multiple benefits to people. Based on ecological theory, we pose that the HDP nexus is broadly applicable across systems, disciplines, and sectors, and should thus be considered in future decision making as a way to have a more sustainable global future.
WAVE-DAMPENED2-LIKE4 modulates the hyper-elongation of light-grown hypocotyl cells
Authors: Schaefer Kristina , Cairo Baza Ariadna , Huang Tina , Cioffi Timothy , Elliott Andrew , Shaw Sidney L 
Published: April 2023

Abstract
Light, temperature, water, and nutrient availability influence how plants grow to maximize access to resources. Axial growth, the linear extension of tissues by coordinated axial cell expansion, plays a central role in these adaptive morphological responses. Using Arabidopsis (Arabidopsis thaliana) hypocotyl cells to explore axial growth control mechanisms, we investigated WAVE-DAMPENED2-LIKE4 (WDL4), an auxin-induced, microtubule-associated protein and member of the larger WDL gene family shown to modulate hypocotyl growth under changing environmental conditions. Loss-of-function wdl4 seedlings exhibited a hyper-elongation phenotype under light conditions, continuing to elongate when wild-type Col-0 hypocotyls arrested and reaching 150% to 200% of wild-type length before shoot emergence. wdl4 seedling hypocotyls showed dramatic hyper-elongation (500%) in response to temperature elevation, indicating an important role in morphological adaptation to environmental cues. WDL4 was associated with microtubules under both light and dark growth conditions, and no evidence was found for altered microtubule array patterning in loss-of-function wdl4 mutants under various conditions. Examination of hormone responses showed altered sensitivity to ethylene and evidence for changes in the spatial distribution of an auxin-dependent transcriptional reporter. Our data provide evidence that WDL4 regulates hypocotyl cell elongation without substantial changes to microtubule array patterning, suggesting an unconventional role in axial growth control.
The Dimensions, Origins, and Consequences of Belief in Donald Trump’s Big Lie
Authors: Jacobson Gary C 
Published: April 2023

Abstract
Donald Trump’s claim that he actually won the 2020 election, that Joe Biden’s victory was fraudulent and that his presidency is thus illegitimate, has been exhaustively debunked, but large majorities of ordinary Republicans and other Trump voters continue to say they agree with him. Using a wide variety of survey data, this paper examines the dimensions and origins of belief in Trump’s big lie and its effects on the Republican Party, the 2022 elections, and U.S. politics going forward.
The Scanner as the Stimulus: Deficient Gamma-BOLD Coupling in Schizophrenia at Rest
Authors: Jacob Michael S , Sargent Kaia , Roach Brian J , Shamshiri Elhum A , Mathalon Daniel H , Ford Judith M 
Published: April 2023

Abstract
Functional magnetic resonance imaging (fMRI) scanners are unavoidably loud and uncomfortable experimental tools that are necessary for schizophrenia (SZ) neuroscience research. The validity of fMRI paradigms might be undermined by well-known sensory processing abnormalities in SZ that could exert distinct effects on neural activity in the presence of scanner background sound. Given the ubiquity of resting-state fMRI (rs-fMRI) paradigms in SZ research, elucidating the relationship between neural, hemodynamic, and sensory processing deficits during scanning is necessary to refine the construct validity of the MR neuroimaging environment. We recorded simultaneous electroencephalography (EEG)-fMRI at rest in people with SZ (n = 57) and healthy control participants without a psychiatric diagnosis (n = 46) and identified gamma EEG activity in the same frequency range as the background sounds emitted from our scanner during a resting-state sequence. In participants with SZ, gamma coupling to the hemodynamic signal was reduced in bilateral auditory regions of the superior temporal gyri. Impaired gamma-hemodynamic coupling was associated with sensory gating deficits and worse symptom severity. Fundamental sensory-neural processing deficits in SZ are present at rest when considering scanner background sound as a “stimulus.” This finding may impact the interpretation of rs-fMRI activity in studies of people with SZ. Future neuroimaging research in SZ might consider background sound as a confounding variable, potentially related to fluctuations in neural excitability and arousal.
Effect of different sow lactation feeder types and drip cooling on sow bodyweight, litter performance, and feeder cleaning criteria
Authors: Rao Zhong-Xing , Coble Kyle F , Tokach Mike D , Woodworth Jason C , DeRouchey Joel M , D. Goodband Robert , Gebhardt Jordan T 
Published: April 2023

Abstract
A total of 600 sows (line 3; PIC, Hendersonville, TN) were used to evaluate the effect of different lactation feeder types and drip cooling on sow farrowing performance and litter growth performance during the summer. For the feeder evaluation, the trial was conducted in two sequential groups with 300 sows per group. Five 60-farrowing-stall rooms with tunnel ventilation were used for each group. On approximately days 110 to 112 of gestation, sows were blocked by body condition score (BCS), parity, and offspring sire (lines 2 or 3 sires; PIC), then randomly allotted to one of three feeder types: 1) PVC tube feeder, 2) Rotecna feeder (Rotecna), or 3) SowMax feeder (Hog Slat). The three feeder types were placed in one of three stalls with the same sequence from the front to the end of all rooms to balance for environmental effects. For drip cooling evaluation, the trial was conducted during the 2nd group of 300 sows. Drippers were blocked in three of every six farrowing stalls to balance feeder type and environmental effects. After farrowing, sows had ad libitum access to feed. For litter performance data, only pigs from sows bred to line 2 sires were recorded. Line 3 sire pigs were not included in litter performance data, but sows of these pigs were included in sow body weight (BW) and feed disappearance data. After weaning, feeder cleaning time was recorded on a subsample of 67 feeders (19, 23, and 25 for PVC tube, Rotecna, and SowMax, respectively). There was no evidence of difference (P &gt; 0.05) in sow entry BW, exit BW, BW change, and litter performance among the different feeder types. However, sows using the SowMax feeders had decreased (P &lt; 0.05) total feed disappearance, average daily feed disappearance, and total feed cost compared to those fed with the PVC tube feeders. There was a marginal difference (P &lt; 0.10) between feeder types in cleaning time, with PVC tube feeders requiring less time than the Rotecna feeders; however, cleaning time varied greatly between the personnel doing the cleaning. Sows with drip cooling had greater (P &lt; 0.05) feed disappearance, litter growth performance, and subsequent total born, and reduced (P &lt; 0.05) BW change. In conclusion, using a SowMax feeder reduced feed disappearance with no effects on sow and litter performance compared to a PVC tube feeder, and drip cooling improved sow and litter performance during summer.
The difference in the functional water flow network between the stem and current-year root cross-sectional surfaces in Salix gracilistyla stem xylem
Authors: Xiang Yan , Kagawa Akira , Nagai Satoshi , Yasuda Yuko , Utsumi Yasuhiro 
Published: April 2023

Abstract
The dye injection method has been applied to many species to analyze the xylem water transport pathway in trees. However, traditional dye injection methods introduced dye tracers from the surface of cut stems, including several annual rings. Furthermore, the traditional dye injection method did not evaluate radial water movement from the outermost annual rings to the inner annual rings. In this study, we assessed the difference in radial water movement visualized by an injected dye, between stem base cut and current-year root cut samples of Salix gracilistyla Miq., with current-year roots grown hydroponically. The results showed that the number of stained annual rings in the root cut samples was smaller than that in the stem cut samples, and the percentage of stained vessels in the root cut samples was significantly smaller than that in the stem base cut samples in the second and third annual rings. In the current-year root cut samples, water transport mainly occurred in the outermost rings from the current-year roots to leaves. In addition, the theoretical hydraulic conductivity of stained vessels in the stem cut samples was higher in the current-year root cut samples in the second and third annual rings. These findings indicate that the previously reported dye injection method using stem cut samples overestimated the water transport pathway in the inner part of the stems. Moreover, previous hydraulic conductivity measurement methods might not have considered the effects of radial resistance through the annual ring boundary, and they might have overestimated the hydraulic conductivity in the inner annual rings.
Tracking the emergence of antigenic variants in influenza A virus epidemics in Brazil
Authors: Pillai Tara K , Johnson Katherine E , Song Timothy , Gregianini Tatiana S , Tatiana G. Baccin , Wang Guojun , Medina Rafael A , Van Bakel Harm , García-Sastre Adolfo , Nelson Martha I , Ghedin Elodie , Veiga Ana B G 
Published: April 2023

Abstract
Influenza A virus (IAV) circulation patterns differ in North America and South America, with influenza seasons often characterized by different subtypes and strains. However, South America is relatively undersampled considering the size of its population. To address this gap, we sequenced the complete genomes of 220 IAVs collected between 2009 and 2016 from hospitalized patients in southern Brazil. New genetic drift variants were introduced into southern Brazil each season from a global gene pool, including four H3N2 clades (3c, 3c2, 3c3, and 3c2a) and five H1N1pdm clades (clades 6, 7, 6b, 6c, and 6b1). In 2016, H1N1pdm viruses belonging to a new 6b1 clade caused a severe influenza epidemic in southern Brazil that arrived early and spread rapidly, peaking mid-autumn. Inhibition assays showed that the A/California/07/2009(H1N1) vaccine strain did not protect well against 6b1 viruses. Phylogenetically, most 6b1 sequences that circulated in southern Brazil belong to a single transmission cluster that rapidly diffused across susceptible populations, leading to the highest levels of influenza hospitalization and mortality seen since the 2009 pandemic. Continuous genomic surveillance is needed to monitor rapidly evolving IAVs for vaccine strain selection and understand their epidemiological impact in understudied regions.
Microbiome Network Connectivity and Composition Linked to Disease Resistance in Strawberry Plants
Authors: Hassani M. Amine , Gonzalez Omar , Hunter Samuel S. , Holmes Gerald J. , Hewavitharana Shashika S. , Ivors Kelly , Lazcano Cristina 
Published: April 2023

Plants recruit diverse microbial communities from the soil to their roots. Intermicrobial interactions and connectivity in the root microbiome play essential roles in plant health by promoting resistance to soilborne pathogens. However, the understanding of these interactions under field conditions is still scarce. Using a strawberry crop model, we characterized the prokaryotic and the fungal communities in the rhizosphere and the roots of three strawberry cultivars grown under field conditions and displaying varying degrees of resistance to the soilborne fungal pathogen Macrophomina phaseolina. We tested the hypothesis that resistant cultivars assemble distinct bacterial and fungal communities that foster microbial connectivity and mediate disease resistance. Our results show that the soilborne pathogen M. phaseolina does not alter the root microbiome of the three strawberry cultivars. Microbiome comparative analysis indicated that the highly susceptible cultivar Sweet Ann assembled a distinct rhizosphere and root microbiome, whereas the microbiome of the strawberry cultivars Marquis and Manresa were more similar and enriched with potential beneficial microbes. Cooccurrence network analysis revealed that the fungal pathogen M. phaseolina was more peripheral in the microbial network of Sweet Ann compared with Manresa and Marquis. Collectively, these results stress the role of the plant microbiome in mediating resistance against soilborne pathogens and further suggest the role of plant genetic traits in the assembly of beneficial microbiome members. Our study reinforces the eminent role of the plant microbiome as trait selection in breeding programs and the need for further understanding of the genetic and biological mechanisms that mediate microbiome assembly. Uncovering these mechanisms will be key for the future success of plant breeding programs in their fight against soilborne pathogens. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Scalable Early Detection of Grapevine Viral Infection with Airborne Imaging Spectroscopy
Authors: Galvan Fernando E. Romero , Pavlick Ryan , Trolley Graham , Aggarwal Somil , Sousa Daniel , Starr Charles , Forrestel Elisabeth , Bolton Stephanie , Alsina Maria del Mar , Dokoozlian Nick , Gold Kaitlin M. 
Published: April 2023

The U.S. wine and grape industry loses $3B annually due to viral diseases including grapevine leafroll-associated virus complex 3 (GLRaV-3). Current detection methods are labor-intensive and expensive. GLRaV-3 has a latent period in which the vines are infected but do not display visible symptoms, making it an ideal model to evaluate the scalability of imaging spectroscopy-based disease detection. The NASA Airborne Visible and Infrared Imaging Spectrometer Next Generation was deployed to detect GLRaV-3 in Cabernet Sauvignon grapevines in Lodi, CA in September 2020. Foliage was removed from the vines as part of mechanical harvest soon after image acquisition. In September of both 2020 and 2021, industry collaborators scouted 317 hectares on a vine-by-vine basis for visible viral symptoms and collected a subset for molecular confirmation testing. Symptomatic grapevines identified in 2021 were assumed to have been latently infected at the time of image acquisition. Random forest models were trained on a spectroscopic signal of noninfected and GLRaV-3 infected grapevines balanced with synthetic minority oversampling of noninfected and GLRaV-3 infected grapevines. The models were able to differentiate between noninfected and GLRaV-3 infected vines both pre- and postsymptomatically at 1 to 5 m resolution. The best-performing models had 87% accuracy distinguishing between noninfected and asymptomatic vines, and 85% accuracy distinguishing between noninfected and asymptomatic + symptomatic vines. The importance of nonvisible wavelengths suggests that this capacity is driven by disease-induced changes to plant physiology. The results lay a foundation for using the forthcoming hyperspectral satellite Surface Biology and Geology for regional disease monitoring in grapevine and other crop species. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .