bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bibliometric and Visual Analysis of Single Nucleotide Polymorphism
Studies in Depression
Authors: Zhang Zi , Yang Ye , Kong Wan , Huang Shanqing , Tan Yaqian , Huang Shanshan , Zhang Ming , Lu Haoyang , Li Yuhua , Li Xiaolin , Liu Shujing , Wen Yuguan , Shang Dewei 
Published: August 2023

Background:
Genetic polymorphism has been proven to have an important association with
depression, which can influence the risk of developing depression, the efficacy of medications, and
adverse effects via metabolic and neurological pathways. Nonetheless, aspects of the association between
single nucleotide polymorphisms and depression have not been systematically investigated by
bibliometric analysis.

Objective:
The aim of this study was to analyze the current status and trends of single nucleotide polymorphism
research on depression through bibliometric and visual analysis.

Methods:
The Web of Science Core Collection was used to retrieve 10,043 articles that were published
between 1998 and 2021. CiteSpace (6.1 R4) was used to perform collaborative network analysis,
co-citation analysis, co-occurrence analysis, and citation burst detection.

Results:
The most productive and co-cited journals were the Journal of Affective Disorders and Biological
Psychiatry, respectively, and an analysis of the references showed that the most recent research
focused on the largest thematic cluster, “5-HT”, reflecting the important research base in this area.
“CYP2D6” has been in the spotlight since its emergence in 2009 and has become a research hotspot since
its outbreak in 2019. However, “BDNF ”, “COMT ”, “older adults”, “loci”, and “DNA methylation” are
also the new frontier of research, and some of them are currently in the process of exploration.

Conclusion:
These findings offer a useful perspective on existing research and potential future approaches
in the study of the association between single nucleotide polymorphisms and depression,
which may assist researchers in selecting appropriate collaborators or journals.
Assessment of Organ Dysfunction and Underlying Causes in Maternal
Near-miss Cases at Health Care Facilities in Doiwala Block of District
Dehradun – A Retrospective Study
Authors: Kanwar Dhanak , Chaturvedi Jaya , Singh Mahendra , Aggarwal Pradeep , Sharma Nandita , Sadiq Sabiha 
Published: August 2023

Introduction:
The extent of maternal morbidity is a good gauge of a nation's maternal health care system. Maternal near-miss (MNM) cases need to be reviewed because they can indirectly contribute significantly to reducing the maternal mortality ratio in India. MNM cases can provide useful information in this context. Such women who survive these life-threatening conditions arising from complications dur-ing pregnancy, childbirth and post partum (42 days) share many commonalities with those who die be-cause of such complications.

Aim:
To assess the organ dysfunction and the underlying causes, associated/contributory factors associated with “maternal near-miss” cases in pregnant, in labor, post-partum women (upto42 days) in the health care facilities of Doiwala block, district Dehradun.

Materials and Methods:
The present study was conducted over a period of 6 months under the Department
of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh.
The cross-sectional study included the medical record files of all pregnant women attending the Department
of Obstetrics and Gynecology, in the selected healthcare facilities of Doiwala block, district
Dehradun.

:
This study was conducted as per the WHO criteria for “near-miss” by using convenience sampling
for the selection of healthcare facilities. The medical record files of all women who were pregnant,
in labor, or who had delivered or aborted up to 42 days were included from a period of 01.06.2021 –
31.05.2022

Results:
It was found that Out of the women with maternal near-miss (n=91), the majority of women
had coagulation /hematological dysfunction (n=45, 49.4%), followed by neurologic dysfunction
(n=15, 16.4%), cardio-vascular dysfunction (n=11, 12%).

:
Out of the total women with a maternal near-miss (n = 91), 10 women underwent multiple organ
dysfunctions. Of the total 91 maternal near-miss cases, the underlying cause of near-miss was obstetric
hemorrhage in almost half the participants (n=45, 49.5%) followed by hypertensive disorders
(n=36, 39.5%). Eleven women had a pregnancy with abortive outcomes (12%) and 7 women had
pregnancy-related infection.

:
It was also seen that, out of 91 near-miss women, the leading contributory /associated cause was
Anemia (n=89, 97.8%) followed by women having a history of previous cesarean section (n=63,
69.2%). Sixteen women had prolonged /obstructed labor (n = 16, 17.58%).

Conclusion:
Pregnancy should be a positive experience for every woman of childbearing age. A better understanding of pregnancy-related conditions enables early detection of complications and prevents the conversion of mild to moderate maternal morbidity outcomes to severe maternal outcomes with long-term health implications or death. There are already effective measures in place to reduce maternal and new-born mortality and morbidity.
Exploring the Experts' Perspectives on the Most Important Risk Factors of Breast Cancer in Iranian Women: A Qualitative Delphi Consensus
Authors: Roudsari Robab Latifnejad , Taghipour Ali , Najafi Tahereh Fathi , Ebadi Abbas , Shandiz Fatemeh Homaei , Manouchehri Elham 
Published: August 2023

Background:Several methods have been designed to assess the risk of breast cancer. But according to studies conducted in Iran, the risk of Iranian women could not be correctly calculated.Objective:This study aimed to explore the experts' perspectives on the most important risk factors of breast cancer in Iranian women.Method:In round one, the risk factors identified from an integrative review of literature and specialist interviews (Delphi round one) were used to design a questionnaire survey. In round two, specialists were asked to rate the importance of each risk factor. In round three, respondents were asked to reprioritize moderate important risk factors. The items considered very important in round three were included in the core risk factors set.Results:In the first round, a total of 119 items were obtained from the results of an integrative review of the literature and interview with experts. In round two, 30 specialists (response rate 50%) prioritized 119 risk factors of BC, and 43 low, 51 medium and 25 high-level risk factors were identified by the experts. From those, 43 low-level risk factors were removed, and 51 medium-level risk factors were carried forward to round three for consensus. No consensus was reached on any of the risk factors that went into round three (response rate 86.7%). Therefore, 25 high-level risk factors were recognized as the most important risk factors for BC in Iran.Conclusion:This study highlights the items that specialists feel would be most crucial to include in the clinical assessment of breast cancer risk. This study has the potential to provide an appropriate and usable tool for detecting high-risk women in primary health care in Iran.
Preparation, Physicochemical Characterization, and Stability Study of
Lippia origanoides Essential Oil-based Nanoemulsion as a Topical Delivery
System
Authors: Benitez-Llano Carlos Andrés , Florez-Acosta Oscar Albeiro , Velasquez-Polo Darsy Dayana , Mesa-Arango Ana Cecilia , Zapata-Zapata Carolina 
Published: August 2023

Introduction:
Fungal diseases are a priority in research, development, and health care, according to the WHO, mainly due to Candida spp. Essential oils (EOs) of the genus Lippia have demonstrated broad antimicrobial biological activity. Previous studies identified the anti-Candida potential of a thymol/p-cymene chemotype EO from Lippia origanoides H.B.K coded “0018”. Nanoemulsions favor the biological activity of EOs and overcome limitations such as low solubility, instability against oxidizing agents, pH, light, and low permeability.
To develop, characterize, and adjust a prototype of an O/W nanoemulsion containing the "0018” EO from Lippia origanoides for its evaluation in an In vitro permeability study.

Methods:
Nanoemulsions were obtained using a high energy high shear method. Their particle size distribution, Z potential, viscosity, pH, encapsulation efficiency (EE), thermodynamic stability and the Turbiscan Stability Index (TSI) were evaluated. The nanoemulsion prototype was adjusted to improve performance characteristics and microbiological efficacy. Thymol was used as an analyte in the EO quantification using UHPLC-DAD.

Results:
An O/W nanoemulsion with hydrodynamic diameter <200 nm and polydispersity index <0.3, EE >95%, with TSI < 1.5, anti-Candida albicans efficiency >95% was obtained; permeable with a flow of 6.0264 µg/cm2/h and permeability coefficient of 1.3170x10-3 cm/h.

Conclusion:
A pharmaceutical formulation prototype is obtained that maintains the physical and physicochemical characteristics over time. Permeability is verified in an in-vitro model. It is proposed to evaluate its antifungal activity in preclinical or clinical studies as a contribution to the treatment of topical fungal diseases caused by Candida spp., through the use of biological resources and Colombian biodiversity
Bidirectional DC-DC Converter and Improved Electrical Vehicle Dynamic
Response Control
Authors: Kalaichelvan Arulvendhan , Purushothaman Srinivasan , Kamalkannan Muralikrishna , Joseph Nissy , Murugavel Roshan 
Published: August 2023

Background:
In automotive applications where bidirectional power flow is
necessary to lighten the power system, dual active bridge (DAB) converters are frequently
employed. Variations in the required output voltage, erratic input voltage, and shifting loads all
have an impact on this converter. As a result, converter performance has to be improved. To
increase efficiency, the current stress of the DC-DC converter must be optimised. This paper
proposes a control scheme for the coupled inductor bidirectional DC-DC (CIB DC-DC)
converter utilising both model predictive control (MPC) and a proportional-integral (PI)
controller. The integration of these control techniques aims to enhance the performance and
efficiency of the converter.

Methods:
The MPC algorithm is employed to predict the converter's future behaviour based on
a dynamic model, taking into account system constraints and performance criteria. By
optimising the control action over a finite time horizon, the MPC algorithm ensures an optimal
response, considering the current state and anticipated changes. Additionally, a PI controller is
incorporated to augment the control strategy. The proportional component of the PI controller
enables a fast initial response to the error between the desired and actual converter outputs. The
integral component eliminates steady-state errors and provides robustness against disturbances,
resulting in improved overall system performance.

Results:
The proposed control scheme is implemented and evaluated through simulations and
experimental tests on a prototype converter. The results demonstrate the effectiveness of the
combined MPC and PI controller approach.

Conclusion:
The coupled inductor bidirectional DC-DC (CIB DC-DC) converter using MPC
can provide precise control of power flow between two voltage domains, enabling efficient
bidirectional power transfer. The predictive capabilities of MPC allow it to adapt to varying
load conditions and respond quickly to changes, ensuring stable operation and accurate
regulation of voltage and current. Overall, the coupled inductor bidirectional DC-DC converter
controlled using MPC over PI offers improved performance, efficiency, and flexibility
compared to traditional control methods. MPC can handle the complex dynamics response and
non-linear characteristics of the converter, making it suitable for bi-directional vehicle charging
applications, where precise control and high efficiency can be achieved.
A Comprehensive Model Incorporating Multiple Spatial Relations in 3D
Space
Authors: Liu Weiguang , Li Mengmeng , Zhao Yuanyuan , Gao Jixun , Wang Miao , Fang Zhenxi 
Published: August 2023

Aims:
A Comprehensive Model Incorporating Multiple Spatial Relations in 3D Space.

Background:
At present, the research on two-dimensional spatial relation expression and inference
models is relatively mature, but these models cannot be used to deal with three-dimensional
spatial orientation relations. With the application of spatial orientation relations, threedimensional
spatial orientation relations are involved in many fields such as urban architectural
design, robotics, image processing, etc. Two-dimensional spatial orientation relations models
cannot satisfy the needs of three-dimensional spatial applications, so there is an urgent need to
research three-dimensional spatial object orientation relations expression and inference models.

Objective:
This work aims to provide a comprehensive model incorporating multiple spatial
relations in 3D space. The joint representation of direction, distance, and topological relations
describes more complex spatial position relations among objects.

Methods:
Based on this comprehensive model, the computational properties of interval algebra
are used to combine the directional and topological relations.

Result:
The study lays a good foundation for the formal representation and reasoning of spatial
relations between regions, enhances the analyzability of spatial relations between objects, and
improves the accuracy of spatial analysis.

Conclusion:
The main novel contribution of this paper is that we propose a comprehensive orientation
relation model, called 3D-TRD, which considers three spatial orientation relations simultaneously.
The paper gives examples to represent the position relations of two spatial objects
by comparing the RCC8 model, the 3DR46 model, and the comprehensive model to highlight the
advantages of our proposed model. Based on the model, the bidirectional mapping association
method is also used to represent the location of the spatial objects. The first advantage of the 3DTRD
model is that it represents spatial location relations more accurately than 3DR46, RCC8,
and five qualitative distances. The second advantage of the 3D-TRD model is that it proposes a
bidirectional mapping representation in three-dimensional space. The third advantage of the 3DTRD
model is that it provides a good basis for the formal representation and inference study of
the spatial relations between regions.
Association of Catastrophic Health Expenditure With the Risk of Depression in Chinese Adults: Population-Based Cohort Study
Authors: Wang Yaping , Liang Wannian , Liu Min , Liu Jue 
Published: August 2023

Background
Depression is one of the most common mental illnesses, and it may have a lasting effect on one’s whole life. As a form of financial hardship, catastrophic health expenditure (CHE) may be associated with depression. However, current evidence about the relationship between CHE and the risk of depression is insufficient.

Objective
This study aimed to explore the relationship between CHE and the risk of depression among Chinese adults.

Methods
In this study, we used 3 waves of the China Family Panel Studies (CFPS) from 2012, 2016, and 2018. The CFPS are a nationally representative study covering 25 of 31 provinces in Chinese mainland and representing nearly 94.5% of the total population. We selected eligible household heads as participants, divided them into 2 groups by CHE events at baseline (exposed group: with CHE; unexposed group: without CHE), and followed them up. Households with CHE were defined as having out-of-pocket medical expenditures exceeding 40% of the total household nonfood expenditure, and people with depression were identified by the 8-item Centre for Epidemiological Studies Depression Scale (CES-D). We first described the baseline characteristics and used logistical regression to estimate their effects on CHE events. Then, we used Cox proportional hazard models to estimate adjusted hazard ratios and 95% CIs of depression among participants with CHE compared with those without CHE. Finally, we analyzed the subgroup difference in the association between CHE and depression.

Results
Of a total of 13,315 households, 9629 were eligible for analysis. Among them, 6824 (70.9%) were men. The mean age was 50.15 (SD 12.84) years. Only 987 (10.3%) participants had no medical insurance. The prevalence of CHE at baseline was 12.9% (1393/9629). Participants with a higher family economic level (adjusted odds ratio [aOR] 1.15, 95% CI 1.02-1.31) and with the highest socioeconomic development level (aOR 1.18, 95% CI 1.04-1.34) had a higher prevalence of CHE than reference groups. During a median of 71 (IQR 69-72) person-months of follow-up, the depression incidence of participants with CHE (1.41 per 1000 person-months) was higher than those without CHE (0.73 per 1000 person-months). Multivariable models revealed that the adjusted hazard ratio for the incidence of depression in participants with CHE was 1.33 (95% CI 1.08-1.64), and this association appeared to be greater in participants without outpatient services (for interaction, P=.048).

Conclusions
CHE was significantly associated with increased risk of depression among Chinese adults. Concentrated work should be done to monitor CHE, and more efforts to ensure financial protection need to be made to prevent depression, especially for people with high health care needs.
Gender Affirmation–Related Information-Seeking Behaviors in a Diverse Sample of Transgender and Gender-Diverse Young Adults: Survey Study
Authors: Boskey Elizabeth R , Quint Meg , Xu Rena , Kremen Jessica , Estrada Carlos , Tham Regina , Kane Kaiden , Reisner Sari L 
Published: August 2023

Background
Of the 1.6 million transgender and gender-diverse (TGD) people in the United States, approximately 700,000 are youth aged 13-24 years. Many factors make it difficult for TGD young people to identify resources for support and information related to gender identity and medical transition. These range from lack of knowledge to concerns about personal safety in the setting of increased antitransgender violence and legislative limitations on transgender rights. Web-based resources may be able to address some of the barriers to finding information and support, but youth may have difficulty finding relevant content or have concerns about the quality and content of information they find on the internet.

Objective
We aim to understand ways TGD young adults look for web-based information about gender and health.

Methods
In August 2022, 102 young adults completed a 1-time survey including closed- and open-ended responses. Individuals were recruited through the Prolific platform. Eligibility was restricted to people between the ages of 18-25 years who identified as transgender and were residents of the United States. The initial goal was to recruit 50 White individuals and 50 individuals who identified as Black, indigenous, or people of color. In total, 102 people were eventually enrolled.

Results
Young adults reported looking on the internet for information about a broad range of topics related to both medical- and social-gender affirmation. Most participants preferred to obtain information via personal stories. Participants expressed a strong preference for obtaining information from other trans people.

Conclusions
There is a need for accessible, expert-informed information for TGD youth, particularly more information generated for the transgender community by members of the community.
An Implementation Pilot of Web-Based Self-Training Programs on Sexual Dysfunctions in the Dutch Public Sexual Health Setting: Mixed Methods Study
Authors: Zimbile Filippo , Beek Titia , David Silke , Crutzen Rik 
Published: August 2023

Background
Web-based sexual health interventions may be more acceptable to people compared with face-to-face support, given the stigma and embarrassment often associated with sexual problems. The Dutch public sexual health clinics (SHCs) conducted an implementation pilot with 4 web-based self-training programs on sexual dysfunctions (WSTPs) for young people. In addition to a basic sexuality program, the WSTPs focused on the following complaints: pain during intercourse, premature ejaculation, and no sex drive.

Objective
This study aims to gain insight into the potential reach of the freely offered WSTPs; use, acceptance, evaluation, and perceived impact of the WSTPs by young people; and evaluation and acceptance of the WSTPs by nurses of the SHCs.

Methods
A quantitative baseline measurement (BM) and a follow-up measurement (FM) were conducted among the users. In addition, qualitative data were gathered through video interviews with a sample of respondents of the FM and nurses of the SHCs to gain more in-depth insights into their assessment of the WSTPs. Participants were recruited via social media, posters, and referrals by nurses of the SHCs. Quantitative data were analyzed using descriptive statistics. Independent 2-tailed t tests and one-way independent ANOVAs were used to compare the scores between subgroups based on background characteristics. Dependent 2-tailed t tests were used to assess the possible changes between BM and FM. The interviews were analyzed using a thematic analysis.

Results
A total of 1028 young people (aged 16-24 y) completed the BM, 666 started with 1 of the WSTPs, and 104 participants completed the FM. In addition, 8 users and 8 nurses were interviewed. Of the participants who completed the BM, 87.74% (902/1028) experienced moderate (411/1028, 39.98%) to high (491/1028, 47.76%) severity of complaints, of which 20.43% (210/1028) had had them for >1 year and 27.82% (286/1028) even for ≥2 years, and 38.91% (400/1028) were dissatisfied with their sex lives. Only 8.75% (90/1028) had sought professional help in the past 2 years. At FM, users rated satisfaction with their sex life more positively than they did at BM, and they experienced less discomfort from their complaints. The overall rating was positive, with a mean report grade of 7.3 (SD 1.45; on a 10-point scale). Anonymity, clear information and explanation, and practical exercises are indicated as strengths of the WSTPs, leading to more understanding and normalization. Nurses appreciate the high quality of information and accessibility of the WSTPs. They consider them as a valuable addition to the consultation hours.

Conclusions
WSTPs can reach a large number of young people with sexual problems who are less likely to seek professional help. This can result in an improved understanding of their issues, a decrease in complaints, and reduced barriers to communicating with a partner or professional.