bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution and refinement of magnetically guided sentinel lymph node detection in breast cancer: meta-analysis
Authors: Pantiora Eirini , Tasoulis Marios Konstantinos , Valachis Antonios , Eriksson Staffan , Kühn Thorsten , Karakatsanis Andreas , Rubio Isabel T 
Published: December 2022

Abstract

Background
Superparamagnetic iron oxide nanoparticles (SPIO) have been used as a tracer for sentinel lymph node (SLN) localization in breast cancer, demonstrating comparable performance to the combination of radioisotope (RI) and blue dye (BD).

Methods
A systematic literature search and meta-analysis with subgroup and meta-regression analysis were undertaken to update the available evidence, assess technique evolution, and define knowledge gaps. Recommendations were made using the GRADE approach.

Results
In 20 comparative studies, the detection rate was 97.5 per cent for SPIO and 96.5 per cent for RI ± BD (risk ratio 1.006, 95 per cent c.i. 0.992 to 1.019; P = 0.376, high-certainty evidence). Neoadjuvant therapy, injection site, injection volume or nodal metastasis burden did not affect the detection rate, but injection over 24 h before surgery increased the detection rate on meta-regression. Concordance was 99.0 per cent and reverse concordance 97.1 per cent (rate difference 0.003, 95 per cent c.i. −0.009 to 0.015; P = 0.656, high-certainty evidence). Use of SPIO led to retrieval of slightly more SLNs (pooled mean 1.96 versus 1.89) with a higher nodal detection rate (94.1 versus 83.5 per cent; RR 1.098, 1.058 to 1.140; P &lt; 0.001; low-certainty evidence). In meta-regression, injection over 24 h before surgery increased the SPIO nodal yield over that of RI ± BD. The skin-staining rate was 30.8 per cent (very low-certainty evidence), and possibly prevented with use of smaller doses and peritumoral injection.

Conclusion
The performance of SPIO is comparable to that of RI ± BD. Preoperative injection increases the detection rate and nodal yield, without affecting concordance. Whether skin staining and MRI artefacts are reduced by lower dose and peritumoral injection needs to be investigated.
Grasp-specific high-frequency broadband mirror neuron activity during reach-and-grasp movements in humans
Authors: Dreyer Alexander M , Michalke Leo , Perry Anat , Chang Edward F , Lin Jack J , Knight Robert T , Rieger Jochem W 
Published: December 2022

AbstractBroadly congruent mirror neurons, responding to any grasp movement, and strictly congruent mirror neurons, responding only to specific grasp movements, have been reported in single-cell studies with primates. Delineating grasp properties in humans is essential to understand the human mirror neuron system with implications for behavior and social cognition. We analyzed electrocorticography data from a natural reach-and-grasp movement observation and delayed imitation task with 3 different natural grasp types of everyday objects. We focused on the classification of grasp types from high-frequency broadband mirror activation patterns found in classic mirror system areas, including sensorimotor, supplementary motor, inferior frontal, and parietal cortices. Classification of grasp types was successful during movement observation and execution intervals but not during movement retention. Our grasp type classification from combined and single mirror electrodes provides evidence for grasp-congruent activity in the human mirror neuron system potentially arising from strictly congruent mirror neurons.
What works best in hiatus hernia repair, sutures alone, absorbable mesh or non-absorbable mesh? A systematic review and network meta-analysis of randomized clinical trials
Authors: Temperley Hugo C , Davey Matthew G , O’Sullivan Niall J , Ryan Éanna J , Donlon Noel E , Donohoe Claire L , Reynolds John V 
Published: December 2022

Summary
Laparoscopic hiatal hernia repair (HHR) and fundoplication is a common low risk procedure providing excellent control of gastro-oesophageal reflux disease and restoring of normal anatomy at the hiatus. HHR may fail, however, resulting in hiatus hernia (HH) recurrence, and the use of tension-free mesh-augmented hernioplasty has been proposed to reduce recurrence. Previous research on this topic has been heterogeneous, including study methods, mesh type used and technique performed. A systematic review and network meta-analysis were carried out. An electronic systematic research was carried out using ‘PUBMED’, ‘EMBASE’, ‘Medline (OVID)’ and ‘Web of Science’, of articles identifying HHR with suture cruroplasty, non-absorbable mesh (NAM) and absorbable mesh (AM) reinforcement. Eight RCTs with 766 patients were evaluated. NAM had significantly (P &lt; 0.05) lower early recurrence rates (OR: 0.225, 95% CI 0.0342, 0.871) compared with suture repair alone; however, no differences in late recurrences were evident. For AM, no difference in early (0.508, 95% CI 0.0605, 4.81) or late (1.07. 95% CI 0.116, 11.4) recurrence rates were evident compared with the suture only group. Major complication rates were similar in all groups. NAM reinforcement significantly reduced early HH recurrence when compared with sutured cruroplasty alone; however, late recurrence rates were similar with all techniques. Given the limited data in comparing AM with NAM, this study was unable to conclude which composition was significant. We emphasize caution when interpreting small sample size RCTs, and recommend more research with larger randomized studies.
Predictors of late pulmonary vein reconnection in patients with arrhythmia recurrence after cryoballoon ablation—per vein analysis including cardiac computed tomography–based anatomic factors
Authors: Terasawa Muryo , Chierchia Gian-Battista , Al Housari Maysam , Bala Gezim , Cosyns Bernard , Droogmans Steven , Tanaka Kaoru , Belsack Dries , De Mey Johan , Sieira Juan , Brugada Pedro , de Asmundis Carlo , Ströker Erwin 
Published: December 2022

ABSTRACT

Aims
To identify predictors of individual late pulmonary vein (PV) reconnection after second-generation cryoballoon (CB2) ablation. Anatomic indicators of late pulmonary vein reconnection (LPVR) post-CB2 ablation have not yet been studied on an individual PV level, nor weighed against clinical and procedural factors.

Methods and results
Clinical, procedural, and PV anatomic data from 125 patients with a repeat procedure for arrhythmia recurrence after index CB2 ablation were analyzed. Preprocedural computed tomography (CT) evaluated 486 PVs for measurement of size; shape (ovality index); carina width; and orientation angle in frontal (superior/inferior) and transversal (anterior/posterior) plane (with horizontal line 0° as reference and upper/lower half circle as positive/negative value, respectively). Durable isolation in all PVs was demonstrated in 50/125 (40%) patients. Late reconnection rates at the different PVs were as follows: 16% left superior (LS), 12% left inferior (LI), 17% right superior (RS), and 31% right inferior (RI) PV. Multivariable analysis performed per vein showed following independent determinants predicting LPVR: ovality index [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.07–2.41, P = 0.022] and carina width (OR 0.75, CI 0.59–0.96, P = 0.024) for LSPV; carina width (OR 0.71, CI 0.53–0.95, P = 0.020) for LIPV; frontal angle (OR 0.91, CI 0.87–0.95, P &lt; 0.001) for RIPV; and transversal angle (OR 1.15, CI 1.03–1.31, P = 0.032) for RSPV.

Conclusion
Cardiac CT-based evaluation of anatomic PV characteristics presented higher predictive value compared to clinical and procedural variables for individual LPVR after CB2 ablation. Pre-procedural identification of unfavourable PV anatomy might be important to tailor the ablation approach.
Genome-wide analysis of cytochrome P450 genes in Citrus clementina and characterization of a CYP gene encoding flavonoid 3′-hydroxylase
Authors: Liu Xiaojuan , Gong Qin , Zhao Chenning , Wang Dengliang , Ye Xianming , Zheng Guixia , Wang Yue , Cao Jinping , Sun Chongde 
Published: December 2022

Abstract
Cytochrome P450s (CYPs) are the largest family of enzymes in plant and play multifarious roles in development and defense but the available information about the CYP superfamily in citrus is very limited. Here we provide a comprehensive genome-wide analysis of the CYP superfamily in Citrus clementina genome, identifying 301 CYP genes grouped into ten clans and 49 families. The characteristics of both gene structures and motif compositions strongly supported the reliability of the phylogenetic relationship. Duplication analysis indicated that tandem duplication was the major driving force of expansion for this superfamily. Promoter analysis revealed numerous cis-acting elements related to various responsiveness. RNA-seq data elucidated their expression patterns in citrus fruit peel both during development and in response to UV-B. Furthermore, we characterize a UV-B-induced CYP gene (Ciclev10019637m, designated CitF3′H) as a flavonoid 3′-hydroxylase for the first time. CitF3′H catalyzed numerous flavonoids and favored naringenin in yeast assays. Virus-induced silencing of CitF3′H in citrus seedlings significantly reduced the levels of 3′-hydroxylated flavonoids and their derivatives. These results together with the endoplasmic reticulum-localization of CitF3′H in plant suggest that this enzyme is responsible for the biosynthesis of 3′-hydroxylated flavonoids in citrus. Taken together, our findings provide extensive information about the CYP superfamily in citrus and contribute to further functional verification.
Feedback semiglobal stabilization to trajectories for the Kuramoto–Sivashinsky equation
Authors: Rodrigues Sérgio S , Seifu Dagmawi A 
Published: December 2022

AbstractIt is shown that an oblique projection-based feedback control is able to stabilize the state of the Kuramoto–Sivashinsky equation, evolving in rectangular domains, to a given time-dependent trajectory. The actuators consist of a finite number of indicator functions supported in small subdomains. Simulations are presented, in the one-dimensional case under periodic boundary conditions and in the two-dimensional case under Neumann boundary conditions, showing the stabilizing performance of the feedback control.
Climate Relicts: Asian Scorpion Family Pseudochactidae Survived Miocene Aridification in Caves of the Annamite Mountains
Authors: Loria Stephanie F , Ehrenthal Valentin L , Nguyen Anh D , Prendini Lorenzo 
Published: December 2022

AbstractSoutheast Asia is a hotspot of karst systems in the tropics and many relictual taxa have been documented in caves across the region. The ancient, relictual scorpion family Pseudochactidae Gromov 1998 has a disjunct distribution and includes two hypogean subfamilies from caves in the Khammouan-Phong Nha-Kẻ Bàng Karst in the northern Annamite (Trường Sơn) Mountains of Laos and Vietnam, and one epigean subfamily from Central Asia. A recent revision identified six species in the family; however, how these taxa dispersed and diversified into Southeast Asian cave systems has not been tested. In the present contribution, the phylogeny of Pseudochactidae is reconstructed using three mitochondrial and three nuclear markers and 140 morphological characters, divergence time and ancestral range estimation analyses are conducted, and the evolution of troglomorphic characters is investigated. Results confirm a previous hypothesis that Pseudochactidae originated in Eurasia, most likely near the Tajik block in the Carboniferous, supporting the ‘Out of Eurasia’ hypothesis and contradicting the ‘Eurogondwana’ and ‘Out of India’ hypotheses for the origin of Southeast Asian scorpions. Pseudochactidae dispersed across Southeast Asia after the collision of the Cimmerian continent and Indochina with Eurasia in the Late Jurassic. Colonization of Southeast Asian caves began in the Late Cretaceous and was completed by the Miocene. The onset of aridification in Southeast Asia during the Late Miocene resulted in the extinction of epigean Pseudochactidae, whereas hypogean members of the family likely survived within caves in the limestone massifs of the Annamite Mountains, supporting the ‘Climate Relict’ hypothesis.
LATE and potential estrogen-related risk factors collected 30 years earlier: The 90+ Study
Authors: Paganini-Hill Annlia , Montine Thomas J , Bukhari Syed A , Corrada Maria M , Kawas Claudia H , Sajjadi S Ahmad 
Published: December 2022

Abstract
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a recently described neuropathological construct associated with dementia. This study aimed to investigate in an autopsy study, LATE-NC and its associations with potential estrogen-related risk factors collected about 30 years before death. Participants were part of The 90+ Study and had, as part of the Leisure World Cohort Study, provided information on menstrual and reproductive variables and details of use of estrogen replacement therapy (ERT). No menstrual and reproductive variable showed an association with LATE-NC. Use of ERT, especially long-term use (15+ years) and more recent use (within 1 year of completing the questionnaire), was associated with reduced risk. The odds were significantly lower for long-term (0.39, 95% confidence interval [CI]: 0.16–0.95) and recent use (0.39, 95% CI: 0.16–0.91) compared with no use. In conclusion, we found that women who reported long-term ERT in their 50s and 60s had a significantly reduced odds of harboring LATE-NC when they died in the 10th and 11th decades of their lives. Our study adds to the existing literature reporting seemingly protective effect of peri- and postmenopausal ERT against neurodegenerative dementia.
Do plants drive translation reinitiation to dodge nonsense-mediated decay?
Authors: Dong Yihan , Ryabova Lyubov A 
Published: December 2022

This article comments on:Cymerman MA, Saul H, Farhi R, Vexler K, Gottlieb D, Berezin I, Shaul O. 2023. Plant transcripts with long or structured upstream open reading frames in the NDL2 5ʹ UTR can escape nonsense-mediated mRNA decay in a reinitiation-independent manner. Journal of Experimental Botany 74, 91–103.
The art of augmented memory: Remembering with augmented reality application in the case of the Temple of Artemis
Authors: Yılmaz Ahenk , Bodur Oğuz , Komesli Murat , Ölmez Duhan , İnan Yiğit 
Published: December 2022

Abstract
This article focuses on the effects of different representation modes of architectural heritage in augmented reality (AR) applications on remembering. Deterioration of the tangible evidence of architectural heritage compromises not only its visibility in the heritage site, but also its presence in memory. Converging survived features and digitally produced representations of the heritage, AR applications in mobile devices provide the memory of the site with endurance, however what is remembered immensely depends on how the heritage is digitally represented on screen. Conceived as a case study for the method of analysis derived from classical memorizing technique of the art of memory, the ‘[AR]temis’ project, reported in this article, aimed to get insights into the effects of the representational qualities of augmented architectural heritage on remembering and also into future AR projects developed for architectural heritage sites with its original method of analysis to inform design decisions. The research project involved the development of the method of art of augmented memory, the AR application, as well as questionnaires and interviews with the respondents’ on-site tests of the application. The results of this analysis show that the decisions regarding the digital representation of architectural heritage in AR applications entail not only the visual qualities of the heritage per se, but also how the actual site of memory is visualized on screen.
Normalization of Ukrainian letters, numerals, and measures for natural language processing
Authors: Vakulenko Maksym 
Published: December 2022

AbstractThere is still little linguistic data on the Ukrainian language in the context of natural language processing (NLP). At the same time, in view of real perspectives of European integration of Ukraine, its state language will soon probably become one of the European Community languages. This fact draws more and more interest to the possible inclusion of the Ukrainian language in multilingual NLP scenarios. This article aims to provide some important data that are necessary for text-to-speech (TTS) conversion of the Ukrainian language. Relying on Ukrainian phonetics and grammar, we formulate the basic rules governing the normalization of Ukrainian letters, numerals, and measures, which help obtain Ukrainian speech data. The results are presented in tables and strings convenient for coding and further implementation into linguistic tools. These rules are necessary for the TTS tasks arising in various NLP tasks associated with speech synthesis, machine translation, information retrieval, etc.
An epistemic theory of the criminal process, Part II: Packer, Posner and epistemic pressure
Authors: Cullerne Bown William 
Published: December 2022

AbstractThis is Part II of a novel ‘epistemic’ theory of the criminal process. Part I, a formal treatment of how poor measurements degrade control over systems of classification, was published in the last issue. This distinguished four distinct realms of control a policymaker may inhabit and established that the criminal process in the USA is trapped in the third best of these, routinely unable to establish that any policy is better than any other. Here, I first use the new epistemic concepts to mathematize Packer’s influential ‘two models’ theory, both a validation of the formal work and a way of giving it traction in the real world. I then use the new techniques to critique Posner’s law and economics and reject it on methodological grounds. I then argue that the activity of making policy for the criminal process, including any quantativity, is largely a form of ritual. The function of this has been to keep at bay an enduring pressure for rationality, as in Weber’s rationalization thesis, that could not be satisfied. Now that we have the capacity for better measurements, a rational approach is for the first time attainable, and I contemplate the end of the old order.
Probing 3D magnetic fields – I. Polarized dust emission
Authors: Hu Yue , Lazarian A 
Published: December 2022

ABSTRACT
Polarized dust emission is widely used to trace the plane-of-the-sky (POS) component of interstellar magnetic fields in two dimensions. Its potential to access 3D magnetic fields, including the inclination angle of the magnetic fields relative to the line of sight (LOS), is crucial for a variety of astrophysical problems. Based on the statistical features of observed polarization fraction and POS Alfvén Mach number $\overline{M_{\rm A}}_{,\bot }$ distribution, we present a new method for estimating the inclination angle. The magnetic field fluctuations raised by anisotropic magnetohydrodynamic (MHD) turbulence are taken into account in our method. By using synthetic dust emission generated from 3D compressible MHD turbulence simulations, we show that the fluctuations are preferentially perpendicular to the mean magnetic field. We find the inclination angle is the major agent for depolarization, while fluctuations of magnetic field strength and density have an insignificant contribution. We propose and demonstrate that the mean inclination angle over a region of interest can be calculated from the polarization fraction in a strongly magnetized reference position, where $\overline{M_{\rm A}}_{,\bot }^2\ll 1$. We test and show that the new method can trace the 3D magnetic fields in sub-Alfvénic, trans-Alfvénic, and moderately superAlfvénic conditions (0.4 ≲ MA ≲ 1.2). We numerically quantify that the difference of the estimated inclination angle and actual inclination angle ranges from 0° to 20° with a median value of ≤10°.
Which Curve Are We Flattening? The Disproportionate Impact of COVID-19 Among Economically Marginalized Communities in Ontario, Canada, Was Unchanged From Wild-Type to Omicron
Authors: Ma Huiting , Chan Adrienne K , Baral Stefan D , Fahim Christine , Straus Sharon , Sander Beate , Mishra Sharmistha 
Published: December 2022

Abstract
Person-level surveillance (N = 14 million) and neighborhood-level income data were used to explore magnitude of inequalities in COVID-19 hospitalizations and deaths over 5 waves in Ontario, Canada. Despite attempts at equity-informed policies alongside fluctuating levels of public health measures, the magnitude of inequalities in hospitalizations and deaths remained unchanged across waves.
A novel approach to airway management in Pierre Robin syndrome—a case report
Authors: Bhardwaj Ajit , Grewal Ritu , Trivedi Shaleen , Singh Shivinder 
Published: December 2022

ABSTRACT
Pierre Robin syndrome (PRS) neonates are one of the most difficult cases to intubate even for an experienced paediatric anaesthesiologist. We describe a case of a PRS-related anatomical anomaly that hindered attempts to manage the airway and the final approach that made it possible to insert an endotracheal tube (ETT). We describe the novel use of a video ureteroscope (Olympus URF-V2) as an airway endoscope. A 7-day-old, 2-kg boy was referred to our tertiary care hospital with diagnosed PRS. He was planned for correction of the mandible with mandibular distraction osteogenesis under general anaesthesia. Fibreoptic scope (Olympus, Japan) revealed the epiglottis lying on the posterior pharynx, which could not be manoeuvred. Due to repeated attempts, the patient developed laryngospasm, and his pulse arterial oxygen saturation (SpO2) was reduced to 70%. Following jaw thrust and slight pulling of the tongue with Magill’s Forceps, a 150-cm long and 0.035-inch diameter atraumatic, Roadrunner® hydrophilic polyurethane-coated guidewire was introduced through the working channel of the video ureteroscope into the trachea under the vision (and a 3.5-mm ID ETT was railroaded over it and a definitive airway was established). A flexible fibreoptic ureteroscope may be useful in the management of a difficult airway and may become an important tool in the armoury of an anaesthesiologist. At our institute, which is a tertiary care centre, we are now training and utilising video-ureteroscope as an airway endoscope. To our knowledge, there is no documentary evidence of the use of a video ureteroscope for difficult airway management of a neonate.
F-actin regulates the polarized secretion of pollen tube attractants in Arabidopsis synergid cells
Authors: Susaki Daichi , Izumi Rie , Oi Takao , Takeuchi Hidenori , Shin Ji Min , Sugi Naoya , Kinoshita Tetsu , Higashiyama Tetsuya , Kawashima Tomokazu , Maruyama Daisuke 
Published: December 2022

Abstract
Pollen tube attraction is a key event of sexual reproduction in flowering plants. In the ovule, two synergid cells neighboring the egg cell control pollen tube arrival via the active secretion of attractant peptides such as AtLURE1 and XIUQIU from the filiform apparatus (FA) facing toward the micropyle. Distinctive cell polarity together with longitudinal F-actin and microtubules are hallmarks of the synergid cell in various species, though the functions of these cellular structures are unclear. In this study, we used genetic and pharmacological approaches to indicate the roles of cytoskeletal components in FA formation and pollen tube guidance in Arabidopsis thaliana. Genetic inhibition of microtubule formation reduced invaginations of the plasma membrane but did not abolish micropylar AtLURE1.2 accumulation. By contrast, the expression of a dominant-negative form of ACTIN8 induced disorganization of the FA and loss of polar AtLURE1.2 distribution toward the FA. Interestingly, after pollen tube reception, F-actin became unclear for a few hours in the persistent synergid cell, which may be involved in pausing and resuming pollen tube attraction during early polytubey block. Our data suggest that F-actin plays a central role in maintaining cell polarity and in mediating male–female communication in the synergid cell.