bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamified assessment of cognitive performance during moderate hypoxia
Authors: Keeler Jason M. , Tourula Erica , Hite M. Jo , Listman Jennifer B. , Heeger David J. , Port Nicholas L. , Schlader Zachary J. 
Published: July 2023

Introduction
There is a need for rapid and objective assessment tools to identify people at risk of impaired cognitive function during hypoxia.

Purpose
To test the hypotheses that performance on gamified cognitive tests examining the cognitive domains of executive function (Gridshot), working memory (Capacity) and spatial tracking (Multitracker) will be reduced during normobaric exposure to moderate normobaric hypoxia.

Methods
Following three consecutive days of practice, twenty-one healthy adults (27 ± 5 y, 9 females) completed five 1-min rounds of the tablet-based games Gridshot, Capacity, and Multitracker (Statespace Labs, Inc.) at Baseline and 60 and 90 min after exposure to 14.0 ± 0.2% (hypoxia) and 20.6 ± 0.3% (normoxia) oxygen. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Arterial oxyhemoglobin saturation was estimated via forehead pulse oximetry (SpO2). Data were analyzed using ANCOVA with a covariate of Baseline.

Results
Compared to normoxia (98 ± 1%), SpO2 was lower (p < 0.001) at 60 (91 ± 3%) and 90 (91 ± 2%) min of hypoxia. No condition x time interaction effects were identified for any gamified cognitive tests (p ≥ 0.32). A main effect of condition was identified for Capacity (p = 0.05) and Multitracker (p = 0.04), but not Gridshot (p = 0.33). Post hoc analyses of the composite scores for both Capacity (p = 0.11) and Multitracker (p = 0.73) demonstrated no difference between conditions.

Conclusion
Performance on gamified cognitive tests was not consistently affected by acute normobaric moderate hypoxic exposure.
Prescription patterns of granulocyte colony–stimulating factors in patients with breast cancer: A real-world study
Authors: Hsu Shu-Wei , Chiang Shao-Chin , Hsu Jason C. , Ko Yu 
Published: July 2023

Background and objectives
Myelosuppressive chemotherapy is effective for breast cancer but carries a potential risk of febrile neutropenia (FN). Clinical practice guidelines have recommended prophylaxis with granulocyte colony-stimulating factor (G-CSF) to reduce the incidence of FN in patients receiving chemotherapy. We aimed to examine the use of G-CSFs for primary prophylaxis for FN and to see whether it follows the guidelines. In addition, we examined the changes in the use of long-acting and short-acting G-CSFs in patients with breast cancer over the past ten years.

Methods
This was a retrospective observational real-world study. The data were obtained from the clinical research database of three hospitals affiliated with Taipei Medical University. Patients with breast cancer who initiated their first chemotherapy regimen between January 1, 2011, and December 31, 2020, were identified by the ICD codes and their use of filgrastim or pegfilgrastim was identified by the Anatomical Therapeutic Chemical codes. Whether and how G-CSF was prescribed during the study patients’ first chemotherapy regimen was examined, and the annual change in the total number of short- and long-acting G-CSFs prescribed to the study patients from 2011 to 2020 was analyzed.

Results
Among the 2,444 patients who were prescribed at least one of the examined 15 breast cancer chemotherapy drugs, 1,414 did not use any G-CSFs during their first chemotherapy regimen while 145 used G-CSFs for primary prophylaxis and 185 for treatment. Among the patients receiving high FN risk regimens, only 8.6% used G-CSF for primary prophylaxis. The average (± SD) number of days for short-acting G-CSF use was 2.3 (± 1.5) days with a median of 2 days. In addition, it was found that there was a significant reduction in long-acting G-CSF use (p = 0.03) whereas the changes in short-acting G-CSF use over time were not significant (p = 0.50).

Conclusions
Our study results show that G-CSFs are used for primary prophylaxis in a small percentage of patients with breast cancer and the duration of short-acting G-CSF use is relatively short. Considering the significant clinical and economic impact of FN, it is hoped that the prescription patterns of G-CSFs observed can provide an important reference for future clinical practice and reimbursement policy.
Response of metabolic enzymes glutamic oxaloacetate transaminase and glutamate pyruvate transaminase in vivo exposed Oreochromis niloticus against organophosphates and synthetic pyrethroid
Authors: Amin Muhammad , Yousuf Masarrat , Ahmad Naveed , Attaullah Mohammad , Ahmad Saeed , Zekker Ivar , Latif Mehreen , Zeb Alam , Ilahi Ikram , Hadi Fazal , Ullah Ubaid , Buneri Islam Dad , Ikram Muhammad , Nabi Ghulam , Nor Azra Mohamad 
Published: July 2023

Abstract
Organophosphates and synthetic pyrethroid pesticides are used in residential areas and agriculture, discharge into environment, may cause unpredictable toxicity to non-targeted aquatic organisms. The current study aims to assess the effect of these pesticides on the transaminases, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase enzymes activity in brain and gills of Oreochromis niloticus. Fish were exposed for 24 and 48 h (hours) to the LC0 (non-lethal concentrations) of the malathion, chlorpyrifos and λ-cyhalothrin, respectively. For biochemical assay, a spectrophotometer was used. Glutamate oxaloacetate transaminase activity in brain and gill was significantly (p &lt;0.05) elevated and inhibited, respectively, except in 48 h treated samples. The highest (+258%) and lowest (+8.9%) enhancement in this activity was noted in chlorpyrifos and malathion treated gill samples, respectively. The glutamate pyruvate transaminase activity was significantly (p &lt;0.05) enhanced in all treated samples except in 24 h malathion treated brain. The highest (+340.7%) and lowest (+27%) enhancement in this level was recorded in malathion and chlorpyrifos exposed brain and gills samples. Therefore, it is suggested that both these assessments in fish different organs could be used as a useful biomarker to detect environmental pollution. Thus, the alterations in transaminases activity indicated that the tested pesticides are highly toxic to the health of aquatic organisms and should be periodically and regularly monitored in the environment to reduce pollutant stress on non-target biota, particularly fish.
On automorphisms of semistableG-bundles with decorations
Authors: Herrero Andres Fernandez 
Published: July 2023

AbstractWe prove a rigidity result for automorphisms of points of certain stacks admitting adequate moduli spaces. It encompasses as special cases variations of the moduli ofG-bundles on a smooth projective curve for a reductive algebraic groupG. For example, our result applies to the stack of semistableG-bundles, to stacks of semistable Hitchin pairs, and to stacks of semistable parabolicG-bundles. Similar arguments apply to Gieseker semistableG-bundles in higher dimensions. We present two applications of the main result. First, we show that in characteristic 0 every stack of semistable decoratedG-bundles admitting a quasiprojective good moduli space can be written naturally as aG-linearized global quotientY/G, so the moduli problem can be interpreted as a GIT problem. Secondly, we give a proof that the stack of semistable meromorphicG-Higgs bundles on a family of curves is smooth over any base in characteristic 0.
Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series
Authors: Wang Na , Gao Zhichao , He Shuai , Han Mengzhen , Han Wenjie , Liu Xiaolin , Cao Hui , Jing Mingxi , Sun Tao , Xu Junnan 
Published: July 2023

Abstract
A lung abscess is a necrotizing infection caused by microbiomes that lead to the loss of healthy lung tissue. The routine culture is a waste of time and yields false-negative results, and clinicians could only choose empiric therapy or use broad‐spectrum antibiotics, which could significantly contribute to the problem of resistance or aggravate the condition. We report three patients with a routine-culture-negative lung abscess. The presenting symptoms included fever, cough, dyspnea, and chest pain, and a computed tomography scan revealed a lesion in the lungs. The bronchoalveolar lavage fluid and pleural fluid were tested for pathogens using metagenome next-generation sequencing (mNGS), and the results revealed Fusobacterium nucleatum and Streptococcus spp. (S. constellatus, S. intermedius) as the most represented microbial pathogens. Our data demonstrated that mNGS could be a promising alternative diagnostic tool for pathogen detection, and the pathogen lists indicate that it will be important to focus on the Streptococcus genus rather than the dominant Streptococcus spp. in terms of co-infection of pathogen determined by shotgun mNGS.
Cinderella’s Body. A Quantitative Approach to Gender, Embodiment, and Folktale Plots
Authors: Jorgensen Jeana 
Published: July 2023

AbstractThis study utilizes quantitative methods to investigate feminist claims about beauty in a series ofATU 510ACinderellatexts. Youth and beauty are found to be linked, and structurally, the protagonist’s encounter with the donor figure does not further beautify her but rather gives her the tools for social advancement. Articulating links between gender, beauty, and success matters in both tale worlds and the real world given not only the pressure of social norms but also the continued issue of gender-based violence due to masculine entitlement to beautiful women’s bodies.
Clearing method of regional power spot market based on blockchain and distributed data security reading algorithm
Authors: Duan Ruiqin , Zhu Xinchun , Gan Beiyu 
Published: July 2023

Abstract
With the progress of society, the supply of electricity has become an inevitable choice for the development of all walks of life. The stability, safety, and economic dispatch of the electric energy system directly impact the entire country’s economic development, from national defense, military, and even people’s daily life, all closely associated with the smooth running of the network. In the aspect of power grid planning and operation, the economic security dispatching problem of power system is a very typical optimization problem. The problem is how to maximize the operating cost of the system under the premise of satisfying the system’s load limit and safety and stability. Due to the rapid development of power technology, the research on power system security and economic planning is essential. As an important means to promote China’s energy structure adjustment and promote the supply side structural reform, the regional spot electricity market is playing an increasingly important role in building a resource optimization allocation mechanism, improving China’s energy resource allocation efficiency, and promoting social and economic development. However, the development of China’s regional spot power market is still in its infancy, and the transaction price of the regional spot power market is quite different from that of other countries. It was given these problems, this article discusses the use of particle swarm algorithms for secure and economic scheduling of power systems in the context of securely reading blockchains and distributed data. The research results showed that: The introduction of environmental pollution penalty programs improved the priority dispatch of wind and photovoltaic power when considering environmental penalty programs and backup penalties for wind and photovoltaic power. The setting of the coefficient of the environmental penalty term depended on the designer’s emphasis on the priority scheduling of wind power and photovoltaic (PV) power generation (PG), and the standby capacity penalty clause achieved reasonable dispatch and utilization of wind power and PV PG, which reduced the dramatic fluctuations and intermittent volume of the system, and facilitated safe and consistent operation of the network. The research of this paper shows the positive relationship between the blockchain and distributed data security reading algorithm and the clearing method of regional spot power market, and points out a new method for its development.
Chicken feather protein for the thermal stability and combustion performance of rigid polyurethane foam
Authors: Zhang Xu , Sun Simiao , Yuan Dehe , Wang Zhi , Xie Hua , Su Zhanpeng 
Published: July 2023

Abstract
Rigid polyurethane foams (RPUFs) were synthesized with chicken feather protein using the “one-step method” of all-water foaming. Thermogravimetry, pyrolysis kinetics analysis, Cone calorimetry and smoke density (Ds) were used to investigate the effects of chicken feather protein on thermal stability and combustion performance of RPUFs. The results showed that the modified RPUFs with 2.5 wt% chicken feather protein (RPUF-CF1) had the lowest mass loss, the highest integrated program pyrolysis temperature, the highest activation energy, the lowest Ds (13.3), the highest light transmittance (79.3 %), the lowest heat release rate (22.0 kW/m2 and 30.6 kW/m2) and total heat release (2.4 MJ/m2 and 2.8 MJ/m2), which indicated that RPUF-CF1 had better thermal stability and combustion performance. The current research results provide a useful reference for the preparation of RPUFs with good thermal stability by bio-based modification.
There are no broad subjects in Standard Arabic
Authors: Alqarni Muteb , Alanazi Mohammad 
Published: July 2023

Abstract
The current article argues that the multiple nominative constructions of the Japanese type do not exist in Standard Arabic. Based on evidence from binding, A′-interception and Case, the article shows that the so-called ‘broad subject’ is a clitic left-dislocated element base generated in the A′-domain. The article thus follows the spirit of the analysis proposed by Landau (e.g., Landau, Idan. 2009. Against broad subjects in Hebrew. Lingua 119(1). 89–101), who denies the existence of broad subjects in Hebrew, concluding that broad subjects do not exist in Semitic languages at all.
Coming Out Collectively: The Emotions of Latin-American Homosexual Liberation Movements
Authors: Caro Romero Felipe 
Published: July 2023

Abstract
In the article I study the emotions involved in the emergence of the homosexual liberation movement in Latin America. Marked by the radical ideas that came out of the sixties many queer organizations bowed to create a sexual revolution inside the social revolution. Because it was the first-time homosexuality came out to the public in the Latin America, at the same time in different countries, a sort of emotional community was formed. This happened thanks to the radical queer intellectual network that was formed after the Stonewall riots connecting the Americas with Europe. By sharing experiences and ideas I will argue that the Latin American homosexual liberation organizations also shared the process of what I have called coming out collectively, where things leaving shame and sadness, overcoming fear with courage, and building pride or anger were fundamental in the early years of the movement.
Seven Years of Brexit: Economic Geographies of Regional De- and Recoupling
Authors: Glückler Johannes , Wójcik Dariusz 
Published: July 2023

Abstract
This editorial offers a comprehensive introduction to the economic geographies of Brexit. It reviews the state of research on the multiple causes and consequences of the 2016 UK referendum and highlights the role of geographical context in the way that these factors interact in affecting voting behaviour and economic impact. Departing from an appraisal of the literature, we discuss the scope of six original studies collected in the special issue that, each using different analytical methods, present evidence on the impact of Brexit on the relocation of financial services firms, the recoupling of London with the other European financial centres, differences in regional productivity across the UK, as well as on the potential of UK regional policy to offset the disadvantages of financial decoupling from the European Union. Recognizing signs of political and economic disintegration beyond Europe, we conclude by highlighting a need for further research on the economic geographies of de- and recoupling.
Testing a Novel Wearable Device for Motor Recovery of the Elbow Extensor Triceps Brachii in Chronic Spinal Cord Injury
Authors: Germann Maria , Baker Stuart N. 
Published: July 2023

AbstractAfter corticospinal tract damage, reticulospinal connections to motoneurons strengthen preferentially to flexor muscles. This could contribute to the disproportionately poor recovery of extensors often seen after spinal cord injury (SCI) and stroke. In this study, we paired electrical stimulation over the triceps muscle with auditory clicks, using a wearable device to deliver stimuli over a prolonged period of time. Healthy human volunteers wore the stimulation device for ∼6 h and a variety of electrophysiological assessments were used to measure changes in triceps motor output. In contrast to previous results in the biceps muscle, paired stimulation: (1) did not increase the StartReact effect; (2) did not decrease the suppression of responses to transcranial magnetic brain stimulation (TMS) following a loud sound; (3) did not enhance muscle responses elicited by a TMS coil oriented to induce anterior-posterior current. In a second study, chronic cervical SCI survivors wore the stimulation device for ∼4 h every day for four weeks; this was compared with a four-week period without wearing the device. Functional and electrophysiological assessments were repeated at week 0, week 4, and week 8. No significant changes were observed in electrophysiological assessments after paired stimulation. Functional measurements such as maximal force and variability and speed of trajectories made during a planar reaching task also remained unchanged. Our results suggest that the triceps muscle shows less potential for plasticity than biceps; pairing clicks with muscle stimulation does not seem beneficial in enhancing triceps recovery after SCI.
Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation
Authors: Hashimoto Yoshitami , Sadano Kota , Miyata Nene , Ito Haruka , Tanaka Hirofumi 
Published: July 2023

AbstractCMG (Cdc45‐MCM‐GINS) helicase assembly at the replication origin is the culmination of eukaryotic DNA replication initiation. This process can be reconstructed in vitro using defined factors in Saccharomyces cerevisiae; however, in vertebrates, origin‐dependent CMG formation has not yet been achieved partly due to the lack of a complete set of known initiator proteins. Since a microcephaly gene product, DONSON, was reported to remodel the CMG helicase under replication stress, we analyzed its role in DNA replication using a Xenopus cell‐free system. We found that DONSON was essential for the replisome assembly. In vertebrates, DONSON physically interacted with GINS and Polε via its conserved N‐terminal PGY and NPF motifs, and the DONSON‐GINS interaction contributed to the replisome assembly. DONSON's chromatin association during replication initiation required the pre‐replicative complex, TopBP1, and kinase activities of S‐CDK and DDK. Both S‐CDK and DDK required DONSON to trigger replication initiation. Moreover, human DONSON could substitute for the Xenopus protein in a cell‐free system. These findings indicate that vertebrate DONSON is a novel initiator protein essential for CMG helicase assembly.
Automated methodology of calculating parameters for non-traditional technology of heating mode of hydro-storage power plant station
Authors: Olishevskyi Illia , Gusev Oleksandr , Olishevskyi Hennadii 
Published: July 2023

Purpose. Justification of the rational parameters of heat pumps and heat accumulators to ensure the efficient operation of the hydro storage power plant (HSPP) in the heating mode. Development of an automated methodology for calculating rational parameters for a complex system of a hydro storage power plant operating in heating mode.
Methodology. Mathematical analysis and modeling.
Findings. Using the developed automated calculation method, it was analyzed and determined that passing through the heat pump the full flow of water passing through the hydro unit is impractical and ineffective, because the energy consumption in the heat pump compressor is many times higher than the consumption of the hydro unit in pumping mode, which devalues the proposed measure as an energy-saving measure.
The use of a heat pump and a heat accumulator at the hydro storage power plant for hot water supply needs will save a third of conventional fuel costs compared to a boiler unit.
The developed automated technique allows to calculate the limit and rational values of design and operating parameters of the heat pump and heat accumulator, which ensure the heating mode of operation of the hydro storage power plant to meet the needs of hot water supply.
Originality. An automated methodology for calculating the parameters of a complex system has been developed for the hydro storage power plant operating in heating mode. The concept of the maximum heat capacity of the hot water supply of the heat pump is introduced. The concept of the rational heat capacity of the hot water supply of the heat pump is introduced. In addition to the maximum heat capacity and the rational heat capacity modes, the developed method allows you to calculate all the parameters of the heat pump and heat accumulator, which provide the heating mode of the hydro storage power plant, for arbitrary values of the thermal power of hot water supply, with further comparison and analysis of the investigated modes and the selection of the most promising one.
Practical value. The technology of using a heat pump and a heat accumulator to transfer the operation of the hydro storage power plant to the heating mode (hot water supply of residential buildings) is substantiated. The possibility of saving conditional fuel when applying the proposed technology is proven.