bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synecological approach of novelty responses in bird assemblage inhabiting Atlas cedar afforestation (Cedrus atlantica(Endl.) G. Manetti ex Carrière) of Mount M’Cid, Northeastern Algeria
Authors: Menaa Mohcen , Guellati Kaouther , Boutabia Lamia , Telailia Salah , Maazi Mohamed Cherif 
Published: May 2023

Abstract

The degradation of Algerian forests caused by repeated fires, pests, diseases, and illegal cutting has led to significant losses in the natural heritage. Afforestation activities play a crucial role in restoring the degraded ecosystem, but the ecological characteristics of the forests are often overlooked when selecting single or multiple native or exotic coniferous species for afforestation. This study used a multivariate synecological approach (such as, Redundancy Canonical Analysis, a variation partitioning approach based on partial RDA and multivariate regression tree with indicator species) to analyze the relative contributions of environmental factors in forest bird community assembly in Atlas cedar stand afforestations. The survey used the point count method to observe the spatial distribution of breeding forest birds across the wooded landscape with respect to habitat predictors, summarizing woodland physiognomy and landscape-scale variables. A total of 47 forest bird species were observed, and the used multivariate synecological analysis has identified three major patterns of relationships among breeding birds and afforested area: the first was related to changes in tree structure during growth, the second was associated with the height of the grass layer, and the third was the gradient of height elevation.
Application of hydrological indices and GIS for the detection of areas at risk of erosion - case study Oued Rhumel watershed, East Algeria
Authors: Miloud Koussa , Berhail Sabri 
Published: May 2023

Abstract
In Algeria, the loss of water capacity in dams poses a major challenge due to the strong increase in water demand. This loss of resource is due to the silting of basins, one of the most serious consequences of erosion. For geographic information systems to correctly map areas at risk of erosion, hydrological indicators are a great source of information. In this work we used a coupling of the Geographic Information System Weighted Method and hydrological indices (such as slope, curvature, compound topography index, sediment transport index, and stream power index) derived from a digital terrain model with a resolution of 30×30 m, The importance of the spatial analysis tool of the Geographic Information System was used to delineate the vulnerable areas. The results obtained showed that 24.35% of the area of the basin suffer in the zone of high / very high erosion and requires immediate protective interventions
Establishing an ecological network to enhance forest connectivity in the South Korea DMZ
Authors: Lim Chi Hong , Cho Yong Chan 
Published: May 2023

Abstract
This study aimed to establish an ecological network to enhance ecosystem functions in the demilitarized zone (DMZ) of South Korea by improving connectivity of forest landscapes using spatial autocorrelation analysis and the minimum cumulative resistance model. We identified source patches critical for maintaining forest landscape connectivity. The ecological network was derived considering topography and land use of four regions comprising the study area. Morphological spatial pattern analysis was used to select source patches. Among all forest regions in the DMZ, the ratio of the core class was approximately 60%, accounting for the largest area; this was higher toward the east, while that of the edge class was higher toward the west. The average connectivity index (dPC) of core patches in the DMZ was 0.45. A final ecological network with a total length of 452.36 km connecting source patches for each region was derived, connecting the main habitats of the endangered species functioning as an ecological corridor. The total forest area corresponding to the network was 730.17 km2, and the designated forest protection area was 165.84 km2. From this, we identified 564.33 km2 of previously undesignated forest areas as candidates for protected forest areas to enhance forest connectivity in the DMZ.
An Ontology Driven Machine Learning Applications in Public Policy Analysis: A Systematic Literature Review
Authors: Kero ADMAS ABTEW , Demissie Dait , Kekeba Kula 
Published: May 2023

Abstract
This systematic literature review aims to explore the role of ontology-driven machine learning applications in public policy analysis. The study employs the PRISMA methodology to identify and analyze relevant literature published between 2012 and 2022. The review includes studies that investigate the use of machine learning techniques in policy analysis, the integration of ontologies in machine learning models, and the potential of this approach in improving policy-making processes. The findings suggest that ontology-driven machine learning applications have great potential in enhancing the accuracy and efficiency of policy analysis, while also addressing the challenges and limitations of traditional methods. The review provides insights into the key domains, methods, and outcomes of studies on this topic and discusses the implications for future research and practice in public policy analysis.
Characterization and Immunogenicity of Recombinant A. flavus Uox
Modified by Co/EDTA Carbon Dots
Authors: Li Hai-Ling , Gao Xiu-Feng , Li Jing-Ji , Wan Ming-Xia , Zhang Guo-Qi , Li Yong-Sheng 
Published: May 2023

Background:
Uricase (Uox) is a major drug in gout and a supplementary drug in cancer
treatment. Because allergic reactions caused by Uox limit its clinical application,10% Co/EDTA
was used to chemically modify Uox from A. flavus to reduce its immunogenicity.

Methods:
The immunogenicity of Uox and 10% Co/EDTA-Uox was examined by determining the
antibody titer and concentration of IL-2, IL-6, IL-10, and TNF-β in quail and rat serum. Moreover,
we examined the pharmacokinetics of 10% Co/EDTA-Uox in rats and acute toxicity in mice.

Results:
The concentration of UA decreased from 771.85 ± 180.99 to 299.47 ± 20.37 μmoL/L
(p<0.01) in the hyperuricemia model of quails injected by 10% Co/EDTA-Uox. Two-way immuno-
diffusion electrophoresis revealed that 10% Co/EDTA-Uox did not produce antibody, whereas
the antibody titer against Uox was 1:16. The concentrations of four cytokines in the 10%
Co/EDTA-Uox group were significantly lower than in Uox group (p < 0.01); The titer of IgG and
IgM against 10% Co/EDTA-Uox was significantly lower than that against Uox at different serum
dilutions (p < 0.0001). The pharmacokinetic data indicated that the half-life time of 10%
Co/EDTA- Uox (69.315 h) was significantly longer than that of Uox (13.4 h) (p<0.01). The tissue
section of the liver, heart, kidney, and spleen revealed no toxicity in Uox and 10% Co/EDTA- Uox
groups.

Conclusion:
10% Co/EDTA-Uox possesses little immunogenicity, a long half-life time, and a
highly efficient degradation of UA.
Effect of Scapula Focused Interventions on Pain and Disability in Neck
Pain with Mobility Deficits- Protocol for a Single Blinded Randomized
Controlled Trial
Authors: Prakash Nithin , Cleland Joshua , Harikesavan Karvannan 
Published: May 2023

Background:
Neck pain with mobility deficits is a common non-specific disorder often
observed in younger individuals. The abnormal position of the scapula has also been identified as a
risk factor in individuals with neck pain and mobility deficits. Though literature exists regarding
the effects of scapular strengthening exercises, there is a lack of studies that have examined the
effects of scapular strengthening exercises in individuals with neck pain and mobility deficits. This
randomized controlled trial aims to examine the effects of scapula-focused exercises on pain and
disability in individuals with neck pain and mobility deficits.

Methods:
A single-blind (assessor-blinded) randomized controlled trial will be performed. One
hundred and eight participants will be recruited and randomly assigned into two groups. The
intervention group will receive scapula-focused exercises, and the control group will receive neckspecific
exercises. Both groups will receive supervised sessions 3 days per week for 6 weeks and
unsupervised sessions for the remaining weeks. Disability, pain, range of motion, pain pressure
threshold, muscle strength, EMG activity, and sensory-motor functions will be assessed at the
baseline, the 6th week, and the 12th week.

Result:
This study aims to provide the effectiveness of scapular-focused exercises and its effect on
neck pain with mobility deficits.

Conclusion:
Analyzing the results can provide insight into how effective scapular-focused
exercises are when compared to neck exercises.

Clinical Trial Registration Number:
The trial is registered with CTRI India- with clinical trial
registration number CTRI/2021/10/037543.
Using a Clinical Data Warehouse to Calculate and Present Key Metrics for the Radiology Department: Implementation and Performance Evaluation
Authors: Liman Leon , May Bernd , Fette Georg , Krebs Jonathan , Puppe Frank 
Published: May 2023

Background
Due to the importance of radiologic examinations, such as X-rays or computed tomography scans, for many clinical diagnoses, the optimal use of the radiology department is 1 of the primary goals of many hospitals.

Objective
This study aims to calculate the key metrics of this use by creating a radiology data warehouse solution, where data from radiology information systems (RISs) can be imported and then queried using a query language as well as a graphical user interface (GUI).

Methods
Using a simple configuration file, the developed system allowed for the processing of radiology data exported from any kind of RIS into a Microsoft Excel, comma-separated value (CSV), or JavaScript Object Notation (JSON) file. These data were then imported into a clinical data warehouse. Additional values based on the radiology data were calculated during this import process by implementing 1 of several provided interfaces. Afterward, the query language and GUI of the data warehouse were used to configure and calculate reports on these data. For the most common types of requested reports, a web interface was created to view their numbers as graphics.

Results
The tool was successfully tested with the data of 4 different German hospitals from 2018 to 2021, with a total of 1,436,111 examinations. The user feedback was good, since all their queries could be answered if the available data were sufficient. The initial processing of the radiology data for using them with the clinical data warehouse took (depending on the amount of data provided by each hospital) between 7 minutes and 1 hour 11 minutes. Calculating 3 reports of different complexities on the data of each hospital was possible in 1-3 seconds for reports with up to 200 individual calculations and in up to 1.5 minutes for reports with up to 8200 individual calculations.

Conclusions
A system was developed with the main advantage of being generic concerning the export of different RISs as well as concerning the configuration of queries for various reports. The queries could be configured easily using the GUI of the data warehouse, and their results could be exported into the standard formats Excel and CSV for further processing.
Examining Patient Engagement in Chatbot Development Approaches for Healthy Lifestyle and Mental Wellness Interventions: Scoping Review
Authors: Sadasivan Chikku , Cruz Christofer , Dolgoy Naomi , Hyde Ashley , Campbell Sandra , McNeely Margaret , Stroulia Eleni , Tandon Puneeta 
Published: May 2023

Background
Chatbots are growing in popularity as they offer a range of potential benefits to end users and service providers.

Objective
Our scoping review aimed to explore studies that used 2-way chatbots to support healthy eating, physical activity, and mental wellness interventions. Our objectives were to report the nontechnical (eg, unrelated to software development) approaches for chatbot development and to examine the level of patient engagement in these reported approaches.

Methods
Our team conducted a scoping review following the framework proposed by Arksey and O’Malley. Nine electronic databases were searched in July 2022. Studies were selected based on our inclusion and exclusion criteria. Data were then extracted and patient involvement was assessed.

Results
16 studies were included in this review. We report several approaches to chatbot development, assess patient involvement where possible, and reveal the limited detail available on reporting of patient involvement in the chatbot implementation process. The reported approaches for development included: collaboration with knowledge experts, co-design workshops, patient interviews, prototype testing, the Wizard of Oz (WoZ) procedure, and literature review. Reporting of patient involvement in development was limited; only 3 of the 16 included studies contained sufficient information to evaluate patient engagement using the Guidance for Reporting Involvement of Patients and Public (GRIPP2).

Conclusions
The approaches reported in this review and the identified limitations can guide the inclusion of patient engagement and the improved documentation of engagement in the chatbot development process for future health care research. Given the importance of end user involvement in chatbot development, we hope that future research will more systematically report on chatbot development and more consistently and actively engage patients in the codevelopment process.
PEMETAAN POLA SUHU PERMUKAAN TUBUH KUDA MENGGUNAKAN KAMERA TERMAL INFRAMERAH
Authors: Santoso Koekoeh , Hendika Rivangga Yuda , Ulum Mokhamad Fakhrul , . Amrozi , Arif Ridi , Suprayogi Agik , Seminar Kudang Boro 
Published: May 2023

Infrared thermal camera is an alternative and non-invasive method used to identify various physiological and pathological process related to body surface temperature changes. The aim of this research was to study the body surface temperature pattern based on the observed regios. Three horses were randomly selected as animal experiments. Thermal image data was collected at 17.00 – 19.00 WIB for five days. Images were retrieved from seven regios: head, thorax, abdomen, and four lower legs. The result of horse A’s surface temperature in five days on head, thorax, abdomen, front left leg, front right leg, rear left leg, and rear right leg regios were 33.42, 33.49, 33.56, 31.30, 31.48, 31. 33.14, 31.34 °C, respectively. The resulf of horse B’s surface tempereture were 33.55, 33.65, 33.64, 31.45, 31.35, 31.53, 31.48 °C, respectively. The resulf of horse C’s surface tempereture were 33.45, 33.55, 33.60, 31.37, 31.45, 31.34, 31.42 °C, respectively. The result showed that difference on horse A’s rear left leg (p<0.05) because of inflamation. Inflamation recovery process on horse A occured on the fifth day, indicated by a drop in temperature and a change in colors on thermal image. Color noises on some images were color difference between objects and poor color saturation. Color noises on thermal images did not affect the results of temperature interpretation.
POTENSI ANESTETIKA KET-A-XYL® PADA KUCING JANTAN DOMESTIK DI YOGYAKARTA INDONESIA
Authors: Maryatmo Maria Angelica , Rosetyadewi Antasiswa Windraningtyas , Septana Aria Ika , Wijayanti Agustina Dwi 
Published: May 2023

Ket-A-Xyl® (Ket-A-Xyl® 20 ml, AgroVet, Peru) merupakan sediaan anastetika jadi yang telah banyak dipasarkan di Indonesia untuk induksi anastesi pada anjing. Studi ini menguji penggunaan obat Ket-A-Xyl® untuk kastrasi pada kucing. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian Ket-A-Xyl® terhadap parameter fisiologis kucing jantan domestik. Sebanyak 53 ekor kucing jantan domestik dengan berat badan berkisar 1,5 – 5,68 kg dipuasakan selama 8 jam kemudian ditimbang untuk menentukan dosis anestesi. Kucing diinjeksikan sediaan Ket-A-Xyl® secara intramuskular, kemudian diamati dan dicatat perubahan fisiologisnya. Demikian juga untuk onset dan durasi obat dicatat saat kucing memasuki stadium anestesi I hingga tahap recovery. Analisis data parameter fisiologis dilakukan menggunakan aplikasi SPSS dengan uji paired sample t-test. Kelompok yang dibandingkan dalam uji paired sample t-test tersebut adalah kelompok data fisiologis kucing pada tahap stadium III dengan tahap recovery. Hasil analisis data menunjukkan bahwa sediaan Ket-A-Xyl® menimbulkan efek yang signifikan terhadap frekuensi napas (p<0,05), tetapi tidak pada suhu dan frekuensi pulsus. Rata-rata onset dan durasi obat Ket-A-Xyl® menunjukkan waktu yang lebih singkat dibanding studi sebelumnya yang menggunakan obat atropin-ketamin-xylazin. Sediaan anastesi Ket-A-Xyl® berpotensi sebagai obat anestetika yang baik pada kucing domestik karena lebih efisien, onset dan durasi singkat, serta tidak menimbulkan respon fisiologis yang fatal selama penggunaannya.
National trends in hyperglycaemia and diabetic ketoacidosis in children, adolescents and young adults with type 1 diabetes. A challenge due to age, stage of development or is new thinking of service provision needed?
Authors: Holman Naomi , Woch Emilia , Dayan Colin , Warner Justin , Robinson Holly , Young Bob , Elliott Jackie 
Published: May 2023

<p> </p>
<p><strong>Objective</strong></p>
<p>Adolescence is associated with high risk hyperglycaemia. This study examines the phenomenon in a life-course context. </p>
<p><strong>Research design and methods</strong></p>
<p>93,125 people with type 1 diabetes aged 5-30 years were identified from the National Diabetes Audit (NDA) and/or the National Paediatric Diabetes Audit (NPDA) for England and Wales for 2017/18-2019/20. For each audit year the latest HbA1c and hospital admissions for diabetic ketoacidosis (DKA) were identified. Data were analysed in sequential cohorts by year of age. </p>
<p><strong>Results </strong></p>
<p>In childhood, unreported HbA1c measurement was uncommon but by 19 years had increased to 22.3% for males and 17.3% for females, reducing to 17.9% and 13.1% respectively by 30 years. Median HbA1c at 9 years was 7.6% (60mmol/mol) (IQR 7.1%-8.4%, 54-68mmol/mol) in males and 7.7% (61mmol/mol) (8.0%-8.4%, 64-68mmol/mol) in females increasing to 8.7% (72mmol/mol) (7.5%-10.3%, 59-89mmol/mol) and 8.9% (74mmol/mol) (7.7%-10.6%, 61-92mmol/mol) respectively at 19 years before falling to 8.4% (68mmol/mol) (7.4%-9.7%, 57-83mmol/mol) and 8.2% (66mmol/mol) (7.3%-9.7%, 56-82mmol/mol) respectively at 30 years. Annual hospitalisation for DKA rose steadily from 6 years (2.0% for males, 1.4% for females) to peak at 19 years for males (7.9%) and 18 years for females (12.7%) reducing to 4.3% for males and 5.4% for females at 30 years. At all ages over 9 years the prevalence of DKA was higher in females. </p>
<p><strong>Conclusions</strong></p>
<p>HbA1c and the prevalence of DKA increase through adolescence and then decline. Measurement of HbA1c, a marker of clinical review, falls abruptly in the late teenage years. Age-appropriate services are needed to overcome these issues.</p>
<strong>β-cell specific</strong> <em><strong>E2f1 </strong></em><strong>deficiency impairs glucose homeostasis, β-cell</strong> <strong>identity and insulin secretion</strong>
Authors: Oger Frédérik , Bourouh Cyril , Elsa Friano Marika , Courty Emilie , Rolland Laure , Gromada Xavier , Moreno Maeva , Carney Charlène , Rabhi Nabil , Durand Emmanuelle , Amanzougarene Souhila , Berberian Lionel , Derhourhi Mehdi , Blanc Etienne , Anissa Hannou Sarah , Denechaud Pierre-Damien , Benfodda Zohra , Meffre Patrick , Fajas Lluis , Kerr-Conte Julie , Pattou François , Froguel Philippe , Pourcet Benoit , Bonnefond Amélie , Collombat Patrick , Annicotte Jean-Sébastien 
Published: May 2023

<p>The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity, insulin secretion and glucose homeostasis. We show that the β-cell-specific loss of <em>E2f1 </em>function in mice triggers glucose intolerance associated with defective insulin secretion, an altered endocrine cell mass, a downregulation of many β-cell genes and a concomitant increase of non-β-cell markers. Mechanistically, the epigenomic profiling of promoters of these non-β-cell upregulated genes identified an enrichment of bivalent H3K4me3/H3K27me3 or H3K27me3 marks. Conversely, promoters of downregulated genes were enriched in active chromatin H3K4me3 and H3K27ac histone marks. We find that specific E2f1 transcriptional, cistromic and epigenomic signatures are associated with these β-cell dysfunctions, with E2F1 directly regulating several β-cell genes at the chromatin level. Finally, the pharmacological inhibition of E2F transcriptional activity in human islets also impairs insulin secretion and the expression of β-cell identity genes. Our data suggest that E2F1 is critical for maintaining β-cell identity and function through a sustained control of β-cell and non β-cell transcriptional programs. </p>
The Influence of Spirituality and Religiosity in Palliative Care
Authors: Nizamis Kleanthis , Kalliakmanis Vassilios , Koutsoupias Nikolaos , Panagiotopoulos Petros 
Published: May 2023

Abstract
In recent years there has been talk of “Palliative care”, an interdisciplinary approach of care, which focuses on supporting and relieving patients and their family environment in progressive and life-threatening illnesses. Its aim is to provide optimal comfort and quality of life, maintain hope and family cohesion despite the possibility of death and generally support patients and their families in the stages of pain, illness and mourning. The theological approach of palliative care, with the opening of new horizons of view of pain and illness and their management with the help of faith, are challenges for the age of human omnipotence. The factors “spirituality” and “religiosity” have begun in recent years to be taken into account in the multitude of biological, psychological and spiritual factors that affect the body’s psychosomatic response to illness and treatment. In the present study, we are trying to explore the influence of religious faith in the management of physical, psychological, and mental problems, that arise in the parents of children with cancer. The research was conducted on a sample of 133 families facing childhood cancer and the collected data were analyzed using open source software. Purpose of the study is to explore whether belief in God in the general frame of palliative care, can play a decisive role during the childhood illness, managing emotions such as anxiety and fear, and maintaining the parent’s psychological balance.