bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study on the seismic performance of a cold-formed thin-walled steel–concrete composite column-H steel beam frame
Authors: Hou HongJie , Chen ZhiHua , Wang XiuLi 
Published: March 2023

AbstractFor lightweight steel frame structures consisting of steel H-beams and cold-formed steel columns filled with concrete, seismic performance comparison tests and numerical simulation analyses were performed for bare and infilled frames. The effects of the lightweight wall panels, the axial compression ratio and the wall thickness of the steel sections of the columns on the seismic properties of the structure were investigated. The failure of the bare frame was concentrated in the weld fractures at the beam-column joints. When the wall panels were embedded in the frame, the damage was concentrated at the corners and edges of the wall panels and the connectors. The wall panels significantly improved the initial stiffness of the frame, early energy dissipation and resistance, and the wall panel energy dissipation rate was initially as great as 91%. As the axial compression ratio increased, the resistance of the structure significantly decreased. Under monotonic loading, the resistance on the structure with an axial compression ratio of 0.4 was reduced by nearly 44% compared to the structure without axial compression. Increasing the wall thickness of the steel sections of the columns increased the load-bearing capacity of the structure, but the increase diminished with increasing wall thickness.
Frozen fresh blood plasma preserves the functionality of native human α2-macroglobulin
Authors: Mendes Soraia R. , Gomis-Rüth F. Xavier , Goulas Theodoros 
Published: March 2023

AbstractHuman α2-macroglobulin (hα2M) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. Following cleavage within a bait region, hα2M undergoes stepwise transitions from its native, expanded, highly flexible, active conformation to an induced, compact, triggered conformation. As a consequence, the peptidase is entrapped by an irreversible Venus flytrap mechanism. Given the importance of hα2M, biochemical studies galore over more than seven decades have attempted to ascertain its role, typically using authentic hα2M purified from frozen and non-frozen fresh blood plasma, and even outdated plasma. However, hα2M is sensitive once isolated and purified, and becomes heterogeneous during storage and/or freezing, raising concerns about the functional competence of frozen plasma-derived hα2M. We therefore used a combination of native and sodium dodecylsulfate polyacrylamide gel electrophoresis, affinity and ion-exchange chromatography, multi-angle laser light scattering after size-exclusion chromatography, free cysteine quantification, and peptidase inhibition assays with endopeptidases of two catalytic classes and three protein substrates, to characterize the biochemical and biophysical properties of hα2M purified ad hoc either from fresh plasma or frozen fresh plasma after thawing. We found no differences in the molecular or functional properties of the preparations, indicating that protective components in plasma maintain native hα2M in a functionally competent state despite freezing.
Study on mechanical characteristics of anchor drilling rig group for rapid excavating
Authors: Xie Miao , Zhang Hong-yu , Li Yu-qi , Ren Ze , Nie Ren-dong 
Published: March 2023

AbstractAiming at the imbalance problem of excavating and anchoring efficiency ratio in the underground coal mine, a new type of parallel operation unit of excavation-supporting-anchoring is proposed to improve the excavating efficiency. Considering the uneven factors of the roof and floor of the coal mine roadway, the influence of different drilling angles and leg support angles on the leg support force is studied under the condition of simultaneous drilling of multiple drilling rigs. The results show that the maximum support force is 4.002 KN when the leg angle is different and the drilling angle is different. By constructing the coupling vibration model of the multi-drill drilling process and using the Lagrange method to solve the vibration law of key components of the anchorage system, the vibration law of drill pipe under different influencing factors such as cantilever extension, multi-drill simultaneous drilling, and drilling incident angle is studied. The results showed: (1) The vibration of the drill pipe in the cantilever extension state is more severe than that in the retracted state, and the maximum vibration peak reaches 7.61 mm. (2) The vibration response of the drill pipe is the most intense under the condition of four top anchor drilling rigs drilling at the same time. Under the working condition of only two drilling rigs, the vibration response of the drill pipe is the smallest. (3) As the drilling angle of the drilling rig increases, the vibration response of the drill pipe is more severe and the vibration amplitude is larger. A test prototype is built to simulate the actual anchoring drilling process, and the vibration law of the support platform and the drilling rig is obtained through the vibration detection system. The test results show that the vibration law of the key components is approximately the same as the theoretical simulation results. The relevant theoretical results can provide a technical basis for the drilling stability of the anchoring system.
Synchronized oscillations of carbon nanotubes dispersed in solution
Authors: Fukumoto Makoto , Akai Ryunosuke , Yoshida Yume , Sakuma Shin-nosuke , Ono Hayato , Mori Rintaro , Sano Masahito 
Published: March 2023

AbstractAlthough synchronized oscillations are found in a variety of systems and living organisms in nature, there has been no report on technologically important materials. We have observed by a fluorescence microscope that a large number of carbon nanotubes (CNTs) dispersed in an aqueous mixture of the surfactant and dye execute synchronized oscillations spontaneously. The movement was quantified to give a power spectrum, revealing a single, sharp synchronization peak at 20 Hz. It was found not to be affected nor created by external vibrations. The surfactant concentration dependence demonstrates that the Kuramoto model is applicable to describe the CNT synchronization. It is always associated with the power-law noise, indicating the presence of complex heterogeneous networks. These results suggest a highly cooperative form of the sparse CNT network connected with variable linkages.
Isolation of dissolved organic matter from aqueous solution by precipitation with FeCl3: mechanisms and significance in environmental perspectives
Authors: Zhang Jie , Mostofa Khan M. G. , Yang Xuemei , Mohinuzzaman Mohammad , Liu Cong-Qiang , Senesi Nicola , Senesi Giorgio S. , Sparks Donald L. , Teng H. Henry , Li Longlong , Yuan Jie , Li Si-Liang 
Published: March 2023

AbstractFerric ions can bind strongly with dissolved organic matter (DOM), including humic acids (HA), fulvic acids (FA), and protein-like substances, whereas isolation of Fe-DOM precipitates (Fe-DOMP) and their biochemical characteristics remain unclear. In this work FeCl3 was used to isolate DOM components from various sources, including river, lake, soil, cow dung, and standard tryptophan and tyrosine, through precipitation at pH 7.5–8.5. The Fe-DOMP contribute to total DOM by approximately 38.6–93.8% of FA, 76.2% of HA and 25.0–30.4% of tryptophan and tyrosine, whilst fluorescence spectra allowed to monitor/discriminate the various DOM fractions in the samples. The relative intensity of the main infrared peaks such as 3406‒3383 cm−1 (aromatic OH), 1689‒1635 cm−1 (‒COOH), 1523–1504 cm−1 (amide) and 1176–1033 cm−1 (‒S=O) show either to decline or disappear in Fe‒DOMP. These results suggest the occurrence of Fe bonds with various functional groups of DOM, indicating the formation of π–d electron bonding systems of different strengths in Fe‒DOMP. The novel method used for isolation of Fe-DOMP shows promising in opening a new frontier both at laboratory and industrial purposes. Furthermore, results obtained may provide a better understanding of metal–organic complexes involved in the regulation of the long-term stabilization/sequestration of DOM in soils and waters.
Modeling of surface phenomena of liquid Al–Ni alloys using molecular dynamics
Authors: Juárez Hadassa , Yousefi Ensieh , Kunwar Anil , Sun Youqing , Guo Muxing , Moelans Nele , Seveno David 
Published: March 2023

AbstractThis work presents a study on the surface tension of liquid Aluminum–Nickel (Al–Ni) alloys. Obtaining adequate values of surface tension for this system is not a simple task as these alloys present the formation of atomic clusters with short-range order at certain compositions, which dramatically influences surface tension. The Compound Forming Model predicts the influence of these clusters on surface tension, but experimental limitations have obstructed its validation due to deficient thermodynamic data. This work attempts to overcome some of these limitations by using Molecular Dynamics (MD). By comparing the obtained results from MD simulations with those of an equivalent system without clusters, it was possible to infer the role of the atomic clusters on Al–Ni surface tension. It was found that these clusters increase surface tension by decreasing the Al content at the surface. They achieve this reduction in Al content at the surface by trapping Al atoms and hindering their travel to the surface.
RETRACTED ARTICLE: Biological interactions
between micro swimmers and cross fluid with inclined MHD effects in a complex wavy
canal
Authors: Ayub Assad , Shah Syed Zahir Hussain , Asjad Muahmmad Imran , Almusawa Musawa Yahya , Eldin Sayed M. , El-Rahman Magda Abd 
Published: March 2023

AbstractThe significance of studying biological interactions of micro swimmers in a
complex wavy canal with MHD effects lies in its potential to provide insight into the
behavior and dynamics of microorganisms in natural environments that contain complex
fluid flow and magnetic fields. Current investigation explores the biological
interactions between micro swimmers and Cross fluid with inclined MHD effects in a
complex wavy canal. There are several factors of medium for micro swimmers like nature,
magnetic field, liquid rheology and position. These interactions are hereby witnessed by
utilizing the Cross fluid along with Taylor swimming sheet model under the influence of
porous and inclined magnetic effect. Furthermore, two-dimensional complex wavy cervical
canal is being utilized at inclined angle. By help of lubrication assumption, reduction
of momentum equation is made and hence fourth-order differential equation associated
with boundary conditions is obtained. Bvp4c command in Matlab is utilized for this
boundary value problem. Obtained bvp4c solution is verified with finite difference
method and found smooth agreement. Magnetic force enhances the swimming speed and
reduction is seen for the power dissipation and effective role is seen for swimming
motion with cross fluid rheology. The channel walls (peristaltic nature) and porous
medium can be utilized as alternative factors to control the speed of the
propeller.
The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway
Authors: Wang Lei , Han Xiangyu , Li Hui , Lv Chuanfeng , Wang Meng 
Published: March 2023

AbstractLung adenocarcinoma is the most common type of lung cancer. With a rise in new cases worldwide each year, early diagnosis and treatment are very important. Network pharmacology provides the effective way to evaluate poly-pharmacological effects and anticancer molecular mechanisms of drugs. The aim of the present study was to explore the anti-tumor mechanism of ethyl acetate extract of Wenxia Changfu Formula (WFEA) in lung adenocarcinoma by using analytical chemistry, network pharmacology and molecular biology. A total of 193 compounds were identified from WFEA, mainly including esters, phenols, ketones and alkaloids. Totally, 374 targets were regarded as potential targets of WFEA against lung adenocarcinoma. Interestingly, PI3K-AKT was found to be one of the significantly enriched signaling pathways of targets of WFEA against lung adenocarcinoma. AKT1, MMP3, CASP3 and BCL2 had strong binding effect with compound molecules of WFEA. Some combinations with the best docking binding were identified, including quercetin/oleanolic_acid/emodin/aloe_emodin/catechin-AKT1 and quercetin-MMP3. In lung adenocarcinoma cells, the WFEA inhibited the proliferation, migration and invasion, and promoted the apoptosis. Moreover, the WFEA inhibited the mRNA expression of MMP3 and Bcl-2 and promoted the mRNA expression of Caspase3. In addition, WFEA inhibited the protein phosphorylation of AKT and PI3K. The WFEA had a significant inhibitory effect on lung adenocarcinoma cells, which could inhibit cell proliferation, invasion and metastasis, and induce cell apoptosis. The mechanism of action of WFEA may be involved in the regulation of the PI3K-AKT signaling pathway in the lung adenocarcinoma.
Differentiated extracts from freshwater and terrestrial mollusks inhibit virulence factor production in Cryptococcus neoformans
Authors: Gutierrez-Gongora Davier , Raouf-Alkadhimi Fouad , Prosser Ryan S. , Geddes-McAlister Jennifer 
Published: March 2023

AbstractThe human fungal pathogen,Cryptococcus neoformans, is responsible for deadly infections among immunocompromised individuals with the evolution of antifungal resistance driving the solution to discover new compounds that inhibit fungal virulence factors rather than kill the pathogen. Recently, exploration into natural sources (e.g., plants, invertebrates, microbes) of antifungal agents has garnered attention by integrating a One Health approach for new compound discovery. Here, we explore extracts from three mollusk species (freshwater and terrestrial) and evaluate effects against the growth and virulence factor production (i.e., thermotolerance, melanin, capsule, and biofilm) inC. neoformans. We demonstrate that clarified extracts ofPlanorbella pilsbryihave a fungicidal effect on cryptococcal cells comparable to fluconazole. Similarly, all extracts ofCipangopaludina chinensisaffect cryptococcal thermotolerance and impair biofilm and capsule production, with clarified extracts ofCepaea nemoralisalso conveying the latter effect. Next, inhibitory activity of extracts against peptidases related to specific virulence factors, combined with stress assays and quantitative proteomics, defined distinct proteome signatures and proposed proteins driving the observed anti-virulence properties. Overall, this work highlights the potential of compounds derived from natural sources to inhibit virulence factor production in a clinically important fungal pathogen.
Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils
Authors: Jiang Jie , Zhan Xinli , Wei Jianxun , Fan Qie , Li Haowen , Li Hao , Li Shuzhen , Zhao Yong , Yin Guodong , Tang Lin , Wu Yongxiang , Lan Mindong , Qin Yijue , Guo Quan , Xu Weicheng , Lu Ling , Yang Yanwei , Zhang Yitian , Qu Haishun 
Published: March 2023

AbstractAt present, the impact of cuproptosis-related genes in the study of osteosarcoma is largely unknown. Genome-wide data of osteosarcoma and controls were downloaded from 3 different databases, and specific diagnostic models associated with cuproptosis in osteosarcoma were constructed by support vector machines with artificial intelligence, random forest trees and LASSO regression. Differential analysis of immune cell infiltration was examined using routine blood data from 25,665 cases. Differential expression was examined using immunohistochemistry and PCR. PDHA1 and CDKN2A were obtained as specific cuproptosis-related biomarkers for osteosarcoma after artificial intelligence analysis. PDHA1, CDKN2A and neutrophils were differentially expressed in OS and control groups. PDHA1 and CDKN2A are significantly dysregulated in OS and are able to serve as biomarkers of OS.
Predictability of Indian Ocean precipitation and its North Atlantic teleconnections during early winter
Authors: Abid Muhammad Adnan , Kucharski Fred , Molteni Franco , Almazroui Mansour 
Published: March 2023

AbstractThe Tropical Western-Central Indian Ocean (WCIO) precipitation anomalies play an important role in modulating the anomalous climate conditions in the North Atlantic and European (NAE) region during the early boreal winter (November–December; ND) season. In this study, we analyzed the forcing mechanism and predictability for the early winter tropical WCIO precipitation anomalies and its teleconnections to the North Atlantic region. The two main forcing mechanisms emerging are the autumn Indian Ocean Dipole (IOD) and a direct atmospheric teleconnection from El Niño-Southern Oscillation (ENSO). Since the autumn IOD is partially forced by ENSO, their independent contributions are also investigated. We found the IOD dominates over the ENSO contribution. The ECMWF-SEAS5 seasonal re-forecast reproduces these forcing mechanisms well and shows a substantial prediction skill for early winter WCIO precipitation. Moreover, the North Atlantic response to the positive WCIO phase projects spatially onto the positive North Atlantic Oscillation (NAO) phase through atmospheric teleconnections and leads to warming in central and western Europe. This teleconnection is reproduced by ECMWF-SEAS5, but with weaker amplitude. Moreover, a significant prediction skill for the NAO as well as for the central and western European temperature anomalies is noted, which is mostly induced by the Indian Ocean precipitation anomalies during early winter.
The importance of the image forces and dielectric environment in modeling contacts to two-dimensional materials
Authors: Brahma Madhuchhanda , Van de Put Maarten L. , Chen Edward , Fischetti Massimo V. , Vandenberghe William G. 
Published: March 2023

AbstractThe performance of transistors based on two-dimensional (2D) materials is affected largely by the contact resistance due to high Schottky barriers at the metal-2D-material interface. In this work, we incorporate the effect of surrounding dielectrics and image-force barrier-lowering in calculating the resistance of Schottky edge-contacts between a metal and a transition-metal dichalcogenide (TMD) thin layer. The electrostatic potential is computed by solving the Poisson equation numerically. The transmission probability is computed using the Wentzel–Kramers–Brillouin (WKB) approximation using the full-band density of states obtained from density functional theory (DFT). The effect of the image force is obtained analytically using the Coulomb kernel of a point charge with boundary conditions appropriate to the geometry we have considered. We find that the image-force barrier-lowering (IFBL) in edge-contacts is determined mainly by the dielectric permittivity of the surrounding oxide. We find that low-κ surrounding dielectrics are crucial for obtaining low resistance monolayer-TMD edge-contacts. Our results show metal-to-n(p)-type MoS2 (WSe2) edge-contacts with SiO2 as top and bottom insulators, a doping concentration > 1 × 1013cm−2 and a metal work-function < 5.1 eV ( > 4.6 eV) result in a contact resistance as low as 50 Ω ⋅ μm.
Understanding the effect of MXene in a TMO/MXene hybrid catalyst for the oxygen evolution reaction
Authors: Tyndall Daire , Gannon Lee , Hughes Lucia , Carolan Julian , Pinilla Sergio , Jaśkaniec Sonia , Spurling Dahnan , Ronan Oskar , McGuinness Cormac , McEvoy Niall , Nicolosi Valeria , Browne Michelle Philippa 
Published: March 2023

AbstractVery recently, it has been reported that mixed transition metal oxide (TMO)/MXene catalysts show improved performance over TMO only catalysts for the oxygen evolution reaction (OER). However, the reasoning behind this observation is unknown. In this work mixed Co(OH)2/Ti3C2Txwere prepared and characterized for the OER using ex situ and operando spectroscopy techniques in order to initiate the understanding of why mixed TMO/MXene materials show better performances compared to TMO only catalysts. This work shows that the improved electrocatalysis for the composite material compared to the TMO only catalyst is due to the presence of higher Co oxide oxidation states at lower OER overpotentials for the mixed TMO/MXene catalysts. Furthermore, the presence of the MXene allows for a more mechanically robust film during OER, making the film more stable. Finally, our results show that small amounts of MXene are more advantageous for the OER during long-term stability measurements, which is linked to the formation of TiO2. The sensitivity of MXene oxidation ultimately limits TMO/MXene composites under alkaline OER conditions, meaning mass fractions must be carefully considered when designing such a catalyst to minimize the residual TiO2formed during its lifetime.
A scoping review of portable sensing for out-of-lab anterior cruciate ligament injury prevention and rehabilitation
Authors: Tan Tian , Gatti Anthony A. , Fan Bingfei , Shea Kevin G. , Sherman Seth L. , Uhlrich Scott D. , Hicks Jennifer L. , Delp Scott L. , Shull Peter B. , Chaudhari Akshay S. 
Published: March 2023

AbstractAnterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) surgery are common. Laboratory-based biomechanical assessment can evaluate ACL injury risk and rehabilitation progress after ACLR; however, lab-based measurements are expensive and inaccessible to most people. Portable sensors such as wearables and cameras can be deployed during sporting activities, in clinics, and in patient homes. Although many portable sensing approaches have demonstrated promising results during various assessments related to ACL injury, they have not yet been widely adopted as tools for out-of-lab assessment. The purpose of this review is to summarize research on out-of-lab portable sensing applied to ACL and ACLR and offer our perspectives on new opportunities for future research and development. We identified 49 original research articles on out-of-lab ACL-related assessment; the most common sensing modalities were inertial measurement units, depth cameras, and RGB cameras. The studies combined portable sensors with direct feature extraction, physics-based modeling, or machine learning to estimate a range of biomechanical parameters (e.g., knee kinematics and kinetics) during jump-landing tasks, cutting, squats, and gait. Many of the reviewed studies depict proof-of-concept methods for potential future clinical applications including ACL injury risk screening, injury prevention training, and rehabilitation assessment. By synthesizing these results, we describe important opportunities that exist for clinical validation of existing approaches, using sophisticated modeling techniques, standardization of data collection, and creation of large benchmark datasets. If successful, these advances will enable widespread use of portable-sensing approaches to identify ACL injury risk factors, mitigate high-risk movements prior to injury, and optimize rehabilitation paradigms.