bluuebunny/crossref_metadata_2025_split huggingface dataset:
Productive Learning Through Labs: Data Laboratories and Their Value in Undergraduate Education and Scholarly Research
Authors: Gade Emily K. , Wallace Geoffrey P. R. 
Published: April 2023

ABSTRACTData Laboratories (Data Labs)—by which we mean a collaborative, group-based research program that can be conducted inside and/or outside of the classroom and is designed to generate observational datasets—have numerous advantages for undergraduate learning and scholarly research. Undergraduate researchers in Data Labs learn about the actual process of collecting and constructing research-quality data—a skillset that is relevant for both academic and workplace opportunities but otherwise under-covered in most undergraduate political science degrees. This article discusses our experiences in founding and running Data Labs, general guidelines for effective lab structure, positive impacts on undergraduate learning and research output, and challenges to consider.
Dairy food consumption is beneficially linked with iodine status in US children and adults: National Health and Nutrition Examination Surveys 2001–2018
Authors: Qin Yue , Cifelli Christopher J , Agarwal Sanjiv , Fugoni Victor L 
Published: April 2023

AbstractObjectives:The objective of this study was to determine the association between the consumption of dairy foods with urinary iodine concentration (UIC) and iodine deficiency risk in a nationally representative sample of the US population.Design, Setting and Participants:24-hour dietary recall data and laboratory data for UIC (μg/l) from subjects 2+ years old US population participating in National Health and Nutrition Examination Surveys 2001–2018 were used (n26 838) for analyses after adjusting for demographic covariates. Significant associations were assessed atP< 0·05.Results:Mean intakes of total dairy were 2·21, 2·17 and 1·70 cup equivalents (cup eq) among those 2–8, 9–18 and 19+ years, respectively. Of the dairy components, intake of milk was highest followed by cheese and yogurt for all age groups. Total dairy intakes were positively associated with UIC among those 2–8 years (β= 29·9 ± 9·9 μg/l urine/cup eq dairy) and 9–18 years (β= 26·0 ± 4·8 μg/l urine/cup eq dairy) but not associated among those 19+ years. Total dairy intakes were associated with lowered risks (30 %, 21 % and 20 % for among 2–8, 9–18 and 19+ years, respectively) of being classified as iodine insufficient (UIC < 100 μg/l) or lowered risk (47 %, 30 % and 26 % among 2–8, 9–18 and 19+ years, respectively) of being classified as iodine severely deficient (UIC < 20 μg/l).Conclusions:The results indicate that dairy foods are beneficially associated with UIC and lowered iodine deficiency risk.
Kant on Mind-Dependence: Possible or Actual Experience?
Authors: Kohl Markus 
Published: April 2023

AbstractIn Kant’s idealism, all spatiotemporal objects depend on the human mind in a certain way. A central issue here is whether the existence of spatiotemporal things requires that these things are, at least at some point, objects of some actual experience or of a merely possible experience. In this essay, I argue (on textual and philosophical grounds) for the latter view: spatiotemporal things exist (or spatiotemporal events occur) if they are objects of a (suitably qualified) possible experience.
Manning Clark’s Repudiation of Anglicanism and the Appeal of ‘Sentimental Humanism’ in his Quest for Grace
Authors: Moses John A. 
Published: April 2023

AbstractManning Clark is regarded as a pioneer of Australian national history. His output has been unequalled but it has provoked a vigorous division of opinions concerning its accuracy and the all-pervading thesis that Australia, to achieve its true national self-perception, must throw off the British heritage that included the baleful influence of the Anglicanism in which Clark was raised by his priest father. Here the work of three key scholarly critics, namely Dr George Shaw, Professor Brian Fletcher and Professor Alan Atkinson is evaluated, all of whom are Anglican historians of Australia. They have made very different assessments of the evolution of Australian national identity and the permanence of the British heritage. Shaw, as a former student of Clark, has assessed his mentor’s work not as rigorous history but essentially as ‘sentimental humanism’. As well, the opportunity is taken to reflect on the two extensive biographies of Clark, namely by Brian Matthews and Mark McKenna. Both these men were educated as Roman Catholics at a time when Rome was decidedly allergic to the idea of ecumenical outreach. Consequently, it is argued here that an accurate assessment of Manning Clark’s oeuvre is yet to be accomplished.
Paternal and Maternal Problem Drinking and Lifetime Problem Drinking of Their Adult Children
Authors: Sipilä Pyry N. , Keski-Rahkonen Anna , Lindbohm Joni V. , Rose Richard J. , Kaprio Jaakko 
Published: April 2023

AbstractParents’ alcohol use is associated with alcohol use of their adolescent offspring, but does this association extend to the adulthood of the offspring? We examined associations of paternal and maternal problem drinking with lifetime problem drinking of their adult offspring prospectively assessed in a population-based Finnish twin-family cohort (FinnTwin16). Problem drinking (Malmö-modified Michigan Alcoholism Screening Test) was self-reported separately by mothers and fathers when their children were 16. The children reported on an extended lifetime version of the same measure during their mid-twenties (21-28 years) and mid-thirties (31-37 years). 1235 sons and 1461 daughters in mid-twenties and 991 sons and 1278 daughters in mid-thirties had complete data. Correlations between fathers’ and their adult children’s problem drinking ranged from .12 to .18. For mothers and their adult children, these correlations ranged from .09 to .14. In multivariate models, adjustment for potential confounders had little effect on the observed associations. In this study, parental problem drinking was modestly associated with lifetime problem drinking of their adult children. This association could be detected even when the children had reached the fourth decade of life.
Enlist™ corn tolerance to preemergence and postemergence applications of synthetic auxin and ACCase-inhibiting herbicides
Authors: Godar Amar S. , Norsworthy Jason K. , Barber Tom L. 
Published: April 2023

AbstractAllowing the use of two additional modes of action (MOAs), Enlist™ corn is a novelty in the continuum of herbicide-resistant crop development efforts that have occurred since the 1990s. Knowledge of Enlist corn tolerance to labeled herbicides and other herbicides within the same MOA for various use and/or exposure scenarios is not well established. Four site-year field experiments for preemergence (PRE) and postemergence (POST) applications were conducted at sites in Fayetteville (2021 and 2022) and Tillar (2020 and 2021), Arkansas, to evaluate Enlist corn response following PRE or POST applications of synthetic auxin herbicides or those that inhibit acetyl-CoA carboxylase (ACCase). A non-Enlist and an Enlist corn hybrid were used for each herbicide treatment to establish differential tolerance. Injury response to PRE application varied among site-years; clethodim was the only herbicide that occasionally caused significant (7% to 17%) injury to Enlist corn. None of the PRE treatments affected plant height, stand, or yield of Enlist corn; these responses were generally similar or better for Enlist corn compared to non-Enlist corn. Enlist corn showed significant injury to POST applications of florpyrauxifen-benzyl (>10%), fluazifop-P-butyl and quizalofop-P-ethyl (>5%), and clethodim and sethoxydim (>75%) 1 wk after application (WAA). These initial injury responses to clethodim and sethoxydim were generally reflected in Enlist corn yield; however, the minimal injury from fluazifop-P-butyl and quizalofop-P-ethyl did not affect yield. Injury to non-Enlist corn with POST-applied ACCase-inhibiting herbicides 2 WAA was >80%, resulting in a proportionate yield reduction. Even though florpyrauxifen-benzyl caused more initial injury to non-Enlist corn, yield reduction in non-Enlist corn was occasionally less than of Enlist corn, with both hybrids experiencing >75% yield reduction. In summary, Enlist corn may occasionally show transient injury even to labeled herbicides when applied POST, and even though the injury from florpyrauxifen-benzyl is initially mild, it nonetheless results in substantial yield loss.
Small‐Scale Discharges Observed Near the Top of a Thunderstorm
Authors: Scholten O. , Hare B. M. , Dwyer J. , Liu N. , Sterpka C. , Assink J. , Leijnse H. , Veen S. ter 
Published: April 2023

AbstractWe have used the LOw‐Frequency ARray (LOFAR) to image a few lightning flashes during a particularly severe thunderstorm. The images show an exceptional amount of VHF activity at altitudes above 10 km. Much of this is in the form of small‐scale discharges, not exceeding a few hundred meter, occurring seemingly randomly around the centers of active storm cells. To emphasize the incidental nature of these small‐scale discharges or sparks we refer to them as “sparkles.” A detailed investigation shows evidence that these sparkles are indicative of positive leader channels and that they are equivalent to the needle activity seen around positive leader tracks at lower altitudes.
The Flux‐Differencing Discontinuous Galerkin Method Applied to an Idealized Fully Compressible Nonhydrostatic Dry Atmosphere
Authors: Souza A. N. , He J. , Bischoff T. , Waruszewski M. , Novak L. , Barra V. , Gibson T. , Sridhar A. , Kandala S. , Byrne S. , Wilcox L. C. , Kozdon J. , Giraldo F. X. , Knoth O. , Marshall J. , Ferrari R. , Schneider T. 
Published: April 2023

AbstractDynamical cores used to study the circulation of the atmosphere employ various numerical methods ranging from finite‐volume, spectral element, global spectral, and hybrid methods. In this work, we explore the use of Flux‐Differencing Discontinuous Galerkin (FDDG) methods to simulate a fully compressible dry atmosphere at various resolutions. We show that the method offers a judicious compromise between high‐order accuracy and stability for large‐eddy simulations and simulations of the atmospheric general circulation. In particular, filters, divergence damping, diffusion, hyperdiffusion, or sponge‐layers are not required to ensure stability; only the numerical dissipation naturally afforded by FDDG is necessary. We apply the method to the simulation of dry convection in an atmospheric boundary layer and in a global atmospheric dynamical core in the standard benchmark of Held and Suarez (1994, https://doi.org/10.1175/1520-0477(1994)075〈1825:apftio〉2.0.co;2).
Post-transcriptional modification of m6A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer
Authors: Li Yang , Zhu Shimiao , Chen Yutong , Ma Qianwang , Kan Duo , Yu Wenyue , Zhang Boya , Chen Xuanrong , Wei Wanqing , Shao Yi , Wang Keruo , Zhang Mingpeng , Deng Shu , Niu Yuanjie , Shang Zhiqun 
Published: April 2023

AbstractAs the most common modification of RNA, N6-methyladenosin (m6A) has been confirmed to be involved in the occurrence and development of various cancers. However, the relationship between m6A and castration resistance prostate cancer (CRPC), has not been fully studied. By m6A-sequencing of patient cancer tissues, we identified that the overall level of m6A in CRPC was up-regulated than castration sensitive prostate cancer (CSPC). Based on the analysis of m6A-sequencing data, we found m6A modification level of HRas proto-oncogene, GTPase (HRAS) and mitogen-activated protein kinase kinase 2 (MEK2 or MAP2K2) were enhanced in CRPC. Specifically, tissue microarray analysis and molecular biology experiments confirmed that METTL3, an m6A “writer” up-regulated after castration, activated the ERK pathway to contribute to malignant phenotype including ADT resistance, cell proliferation and invasion. We revealed that METTL3-mediated ERK phosphorylation by stabilizing the transcription of HRAS and positively regulating the translation of MEK2. In the Enzalutamide-resistant (Enz-R) C4-2 and LNCap cell line (C4-2R, LNCapR) established in the current study, the ERK pathway was confirmed to be regulated by METTL3. We also found that applying antisense oligonucleotides (ASOs) to target the METTL3/ERK axis can restore Enzalutamide resistance in vitro and in vivo. In conclusion, METTL3 activated the ERK pathway and induced the resistance to Enzalutamide by regulating the m6A level of critical gene transcription in the ERK pathway.
Durability of neutralizing RSV antibodies following nirsevimab administration and elicitation of the natural immune response to RSV infection in infants
Authors: Wilkins Deidre , Yuan Yuan , Chang Yue , Aksyuk Anastasia A. , Núñez Beatriz Seoane , Wählby-Hamrén Ulrika , Zhang Tianhui , Abram Michael E. , Leach Amanda , Villafana Tonya , Esser Mark T. 
Published: April 2023

AbstractNirsevimab is an extended half-life monoclonal antibody specific for the prefusion conformation of the respiratory syncytial virus (RSV) F protein, which has been studied in preterm and full-term infants in the phase 2b and phase 3 MELODY trials. We analyzed serum samples collected from 2,143 infants during these studies to characterize baseline levels of RSV-specific immunoglobulin G antibodies and neutralizing antibodies (NAbs), duration of RSV NAb levels following nirsevimab administration, the risk of RSV exposure during the first year of life and the infant’s adaptive immune response to RSV following nirsevimab administration. Baseline RSV antibody levels varied widely; consistent with reports that maternal antibodies are transferred late in the third trimester, preterm infants had lower baseline RSV antibody levels than full-term infants. Nirsevimab recipients had RSV NAb levels >140-fold higher than baseline at day 31 and remained >50-fold higher at day 151 and >7-fold higher at day 361. Similar seroresponse rates to the postfusion form of RSV F protein in nirsevimab recipients (68–69%) compared with placebo recipients (63–70%; not statistically significant) suggest that while nirsevimab protects from RSV disease, it still allows an active immune response. In summary, nirsevimab provided sustained, high levels of NAb throughout an infant’s first RSV season and prevented RSV disease while allowing the development of an immune response to RSV.
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
Authors: Li Xiaofei , Andrusivova Zaneta , Czarnewski Paulo , Langseth Christoffer Mattsson , Andersson Alma , Liu Yang , Gyllborg Daniel , Braun Emelie , Larsson Ludvig , Hu Lijuan , Alekseenko Zhanna , Lee Hower , Avenel Christophe , Kallner Helena Kopp , Åkesson Elisabet , Adameyko Igor , Nilsson Mats , Linnarsson Sten , Lundeberg Joakim , Sundström Erik 
Published: April 2023

AbstractThe spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5–12. This revealed how the cell fate commitment of neural progenitor cells and their spatial positioning are spatiotemporally regulated by specific gene sets. We identified unique events in human spinal cord development relative to rodents, including earlier quiescence of active neural stem cells, differential regulation of cell differentiation and distinct spatiotemporal genetic regulation of cell fate choices. In addition, by integrating our atlas with pediatric ependymomas data, we identified specific molecular signatures and lineage-specific genes of cancer stem cells during progression. Thus, we delineate spatiotemporal genetic regulation of human spinal cord development and leverage these data to gain disease insight.
Validation of subjective manual palpation using objective physiological recordings of the cranial rhythmic impulse during osteopathic manipulative intervention
Authors: Pelz Holger , Müller Gero , Keller Micha , Mathiak Klaus , Mayer Johannes , Borik Stefan , Perlitz Volker 
Published: April 2023

AbstractIntermediate (IM) band physiology in skin blood flow exhibits parallels with the primary respiratory mechanism (PRM) or cranial rhythmic impulse (CRI), controversial concepts of osteopathy in the cranial field (OCF). Owing to inconsistent manual palpation results, validity of evidence of PRM/CRI activity has been questionable. We therefore tried to validate manual palpation combining instrumented tracking and algorithmic objectivation of frequencies, amplitudes, and phases. Using a standard OCF intervention, cranial vault hold (CVH), two OCF experts palpated and digitally marked CRI frequencies in 25 healthy adults. Autonomic nervous system (ANS) activity in low frequency (LF) and IM band in photoplethysmographic (PPG) forehead skin recordings was probed with momentary frequency of highest amplitude (MFHA) and wavelet amplitude spectra (WAS) in examiners and participants. Palpation errors and frequency expectation bias during CVH were analyzed for phases of MFHA and CRI. Palpated CRI frequencies (0.05–0.08 Hz) correlated highly with mean MFHA frequencies with 1:1 ratio in 77% of participants (LF-responders; 0.072 Hz) and with 2:1 ratio in 23% of participants (IM-responders; 0.147 Hz). WAS analysis in both groups revealed integer number (harmonic) waves in (very) low and IM bands in > 98% of palpated intervals. Phase analyses in participants and examiners suggested synchronization between MFHA and CRI in a subset of LF-responders. IM band physiology in forehead PPG may offer a sensible physiological correlate of palpated CRI activity. Possible coordination or synchronization effects with additional physiological signals and between examiners and participants should be investigated in future studies.
iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation
Authors: Otsuka Satoshi , Qin Xian-Yang , Wang Wenlong , Ito Tomohiro , Nansai Hiroko , Abe Kuniya , Fujibuchi Wataru , Nakao Yoichi , Sone Hideko 
Published: April 2023

AbstractChemical-induced dysregulation of DNA methylation during the fetal period is known to contribute to developmental disorders or increase the risk of certain diseases later in life. In this study, we developed an iGEM (iPS cell-based global epigenetic modulation) detection assay using human induced pluripotent stem (hiPS) cells that express a fluorescently labeled methyl-CpG-binding domain (MBD), which enables a high-throughput screening of epigenetic teratogens/mutagens. 135 chemicals with known cardiotoxicity and carcinogenicity were categorized according to the MBD signal intensity, which reflects the degree of nuclear spatial distribution/concentration of DNA methylation. Further biological characterization through machine-learning analysis that integrated genome-wide DNA methylation, gene expression profiling, and knowledge-based pathway analysis revealed that chemicals with hyperactive MBD signals strongly associated their effects on DNA methylation and expression of genes involved in cell cycle and development. These results demonstrated that our MBD-based integrated analytical system is a powerful framework for detecting epigenetic compounds and providing mechanism insights of pharmaceutical development for sustainable human health.
The seven phases of match status differentiate the running performance of soccer players in UEFA Champions League
Authors: Konefał Marek , Radzimiński Łukasz , Chmura Jan , Modrić Toni , Zacharko Michał , Padrón-Cabo Alexis , Sekulic Damir , Versic Sime , Chmura Paweł 
Published: April 2023

AbstractThe purpose of this research was to investigate the running performance of professional soccer players in relation to seven phases which resulted in the changing or maintaining the match status in the UEFA Champion League games during season 2020/2021. Moreover, we aimed to define which match status phases occur at the earliest stage of regular game time. This study involved professional soccer players from 24 teams participating in the group stage of UEFA Champions League in season 2020/21. The match status was divided into seven phases that result in changing or maintaining the match outcome: DW (Drawing to Winning); LD (Losing to Drawing); WW (Winning to Winning); DD (Drawing to Drawing); LL (Losing to Losing); DL (Drawing to Losing); WD (Winning to Drawing). Such running performance variables as: total distance covered (TDC) and distance covered in high-intensity running (HIR) were analyzed. Players participating in the UEFA Champions League matches cover the longest TDC in DW, DL and DD phases. TDC in these stages was between 111 and 123 m min−1. The highest HIR was recorded during phases: DW, DL and LL (range between 9.91 and 10.82 m min−1). In contrast, the lowest total distance and distance in HIR is covered during WD phase (only 105.57 ± 1.89 m min−1 and 7.34 m min−1 respectively). On average, phases resulting in the change of the match status occur during the first half, while all phases maintaining the result in the second half. Coaching staffs should consider registering and analysing the physical match performance in relation to described seven match status phases. Such information allows to prepare team-specific training drills, that players should perform more often in order to change or maintain the status of the game.
Ultrasound-guided lateral branch radiofrequency neurotomy for sacroiliac joint pain after lumbosacral spinal fusion surgery
Authors: Le Viet-Thang , Nguyen Anh Minh , Do Phuoc Trong 
Published: April 2023

AbstractOur study evaluated the clinical feasibility of ultrasound-guided lateral branch radiofrequency neurotomy for sacroiliac joint (SIJ) pain after lumbosacral spinal fusion surgery (LSFS). This prospective study included a total of 46 patients who were diagnosed with SIJ pain after LSFS, did not respond to conservative treatment and therefore underwent ultrasound-guided SIJ radiofrequency neurotomy (RFN) from January 2019 to January 2022. These patients were followed up for twelve months after the procedure. Patients were assessed with the Numeric Rating Scale (NRS) and the Oswestry Disability Index (ODI) preprocedural and postprocedural for 1 month, 6 months and 12 months follow-ups. There was a significant improvement in postprocedural NRS and ODI scores (p < 0.001). Thirty-eight patients (82.6%) had a satisfactory response and good global perceived effect (GPE) after twelve months. No significant complications were observed during the 12-month follow-up. The ultrasound-guided radiofrequency device designed as a safe, easily applied and encouraging method could avoid revision surgery. It is a promising technique and has shown good results in providing intermediate pain relief. In addition to the limited series reported in the literature, future studies will add meaning to this topic by including it in routine practice.