bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of studies reporting on neuropsychological and functional domains used for assessment of recovery from delirium in acute hospital patients
Authors: McCartney Haruno , Noble Erin , MacLullich Alasdair M. J. , Davis Daniel H. J. , Evans Jonathan , Shenkin Susan D. , Muniz‐Terrera Graciela , Sandeman Daisy , Tieges Zoë 
Published: June 2023

AbstractObjectivesAssessing for recovery in delirium is essential in guiding ongoing investigation and treatment. Yet, there is little scrutiny and no research or clinical consensus on how recovery should be measured. We reviewed studies which used tests of neuropsychological domains and functional ability to track recovery of delirium longitudinally in acute hospital settings.Methods/DesignWe systematically searched databases (MEDLINE, PsycInfo, CINAHL, Embase,ClinicalTrials.gov, Cochrane Central Register of Controlled Trials), from inception to October 14th, 2022. Inclusion criteria were: adult acute hospital patients (≥18 years) diagnosed with delirium by a validated tool; 1+ repeat assessment using an assessment tool measuring domains of delirium/functional recovery ≤7 days from baseline. Two reviewers independently screened articles, performed data extraction, and assessed risk of bias. A narrative data synthesis was completed.ResultsFrom 6533 screened citations, we included 39 papers (reporting 32 studies), with 2370 participants with delirium. Studies reported 21 tools with an average of four repeat assessments including baseline (range 2–10 assessments within ≤7 days), measuring 15 specific domains. General cognition, functional ability, arousal, attention and psychotic features were most commonly assessed for longitudinal change. Risk of bias was moderate to high for most studies.ConclusionsThere was no standard approach for tracking change in specific domains of delirium. The methodological heterogeneity of studies was too high to draw firm conclusions on the effectiveness of assessment tools to measure delirium recovery. This highlights the need for standardised methods for assessing recovery from delirium.
Marginal zone lymphomas
Authors: Zucca Emanuele , Rossi Davide , Bertoni Francesco 
Published: June 2023

AbstractThe three main types of marginal zone lymphoma (MZL), recognized by the current lymphoma classifications are the extranodal MZL of mucosa‐associated lymphoid tissue, the splenic MZL, and the nodal MZL. They share some karyotype lesions (trisomies of chromosomes 3 and 18, deletions at 6q23), and alterations of the nuclear factor kappa B (NFkB) pathway are also common in all of them. However, they differ in the presence of recurrent translocations, mutations affecting the Notch signaling pathway (NOTCH2 and less commonly NOTCH1), the transcription factors Kruppel‐like factor 2 (KLF2) or the receptor‐type protein tyrosine phosphatase delta (PTPRD). This review summarizes the most recent and significant advances in our understanding of the epidemiology, genetics, and biology of MZLs and outlines the current principles of the standard management of MZL at different anatomic sites.
Multi‐color two‐photon scanning structured illumination microscopy imaging of live cells
Authors: Wang Meiting , Chen Jiajie , Wu Wenshuai , Wang Lei , Zheng Xiaomin , Xu Gaixia , Qu Junle , Gao Bruce Zhi , Shao Yonghong 
Published: June 2023

AbstractMulti‐color two‐photon microscopy imaging of live cells is essential in biology. However, the limited diffraction resolution of conventional two‐photon microscopy restricts its application to subcellular organelle imaging. Recently, we developed a laser scanning two‐photon non‐linear structured illumination microscope (2P‐NLSIM), whose resolution improved three‐fold. However, its ability to image polychromatic live cells under low excitation power has not been verified. Here, to improve the reconstruction super‐resolution image quality under low excitation power, we increased the image modulation depth by multiplying the raw images with the reference fringe patterns in the reconstruction process. Simultaneously, we optimized the 2P‐NLSIM system to image live cells, including the excitation power, imaging speed, and field of view. The proposed system could provide a new imaging tool for live cells.
RNA Sequencing of Urine‐Derived Cells for the Characterization and Diagnosis of Osteogenesis Imperfecta
Authors: Ludwig Karissa , Wu Zenghui , Bardai Ghalib , Mason Patrizia , Ward Leanne M , Moffatt Pierre , Rauch Frank 
Published: June 2023

ABSTRACTDNA sequencing is a reliable tool for identifying genetic variants in osteogenesis imperfecta (OI) but cannot always establish pathogenicity, particularly in variants altering splicing. RNA sequencing can provide functional evidence of the effect of a variant on the transcript but requires cells expressing the relevant genes. Here, we used urine‐derived cells (UDC) to characterize genetic variants in patients with suspected or confirmed OI and provide evidence on the pathogenicity of variants of uncertain significance (VUS). Urine samples were obtained from 45 children and adolescents; UDC culture was successful in 40 of these participants (age range 4–20 years, 21 females), including 18 participants with OI or suspected OI who had a candidate variant or VUS on DNA sequencing. RNA was extracted from UDC and sequenced on an Illumina NextSeq550 device. Principal component analysis showed that the gene expression profiles of UDC and fibroblasts (based on Genotype Tissue Expression [GTEx] Consortium data) clustered close together and had less variability than those of whole blood cells. Transcript abundance was sufficient for analysis by RNA sequencing (defined as a median gene expression level of ≥10 transcripts per million) for 25 of the 32 bone fragility genes (78%) that were included in our diagnostic DNA sequencing panel. These results were similar to GTEx data for fibroblasts. Abnormal splicing was identified in 7 of the 8 participants with pathogenic or likely pathogenic variants in the splice region or deeper within the intron. Abnormal splicing was also observed in 2 VUS (COL1A1 c.2829+5G>A and COL1A2 c.693+6T>G), but no splice abnormality was observed in 3 other VUS. Abnormal deletions and duplications could also be observed in UDC transcripts. In conclusion, UDC are suitable for RNA transcript analysis in patients with suspected OI and can provide functional evidence for pathogenicity, in particular of variants affecting splicing. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Synthesis and characterization of octopamine sulfate, norfenefrine sulfate and etilefrine sulfate reference materials for doping control
Authors: Kalita Subarna Jyoti , Pawar Sachin Dattram , Vernekar Prachi , Pawar Mayur Arun , Veena KS , Mishra KM Abha , Sethi Kalyan Kumar , Radhakrishnanand P. , Murty Upadhyayula Suryanarayana , Sahu Puran lal , Dubey Sachin , Sahu Kapendra , Upadhyay Awanish , Kori Rajesh Kumar , Kumar Pramod 
Published: June 2023

AbstractBACKGROUNDDoping is the use of prohibited substances by athletes to improve their performance. World Anti‐Doping Agency (WADA)‐accredited laboratories require various metabolite reference standards of the prohibited chemical substances or drugs for routine quality control. Therefore, it was proposed to develop efficient synthetic methodologies for highly pure reference materials of Phase II metabolites of octopamine, norfenefrine and etilefrine, which are prohibited in sports by WADA under the S6 stimulant category. The reference materials were characterized using various analytical techniques. New high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD) methods were developed for purity assessment.RESULTSThe synthesized Phase II metabolite reference standards, i.e. octopamine sulfate, norfenefrine sulfate and etilefrine sulfate, were confirmed by 1H NMR, 13C NMR, liquid chromatography–high‐resolution mass spectrometry (LC‐HRMS), attenuated total reflectance Fourier transform infrared and thermogravimetric analysis. In the LC‐HRMS study, the mass error value of synthesized compounds was less than 10 ppm (error) which confirms the identity of the reference materials. New HPLC‐DAD method were developed to ensure the purity of the reference materials. We used the HILIC column as metabolite reference standards are highly polar. The mobile phase was composed of water and acetonitrile in fixed composition. The HPLC‐DAD purity of the developed reference materials was observed as 100%.CONCLUSIONWe have developed reproducible synthetic routes for octopamine sulfate, norfenefrine sulfate and etilefrine sulfate, which are prohibited in sports by WADA. The synthesized metabolites were characterized using different advanced analytical techniques. These reference standards will be helpful to all WADA‐accredited laboratories in routine anti‐doping testing. © 2023 Society of Chemical Industry (SCI).
Comparative study on K‐tolerance performance of Fe/ZrO2 and Fe/ZrO2‐W catalysts for NH3‐SCR of NOx
Authors: Xu Duo , Han Zhitao , Li Yeshan , Lu Shijian , Pan Xinxiang 
Published: June 2023

AbstractBACKGROUNDSelective catalytic reduction (SCR) of nitrous oxides (NOx) with ammonia (NH3) as reductant is used worldwide in mobile and stationary sources to reach strict emission standards. It is a feasible strategy to modify support with acidic metal oxides to improve the alkali metal potassium (K) tolerance of SCR catalysts. Herein, a comparative investigation was conducted based on iron/zirconium dioxide (Fe/ZrO2)and Fe/ZrO2‐tungsten (W) catalysts to reveal the correlation of support modification with W and K‐tolerance performance.RESULTSThe NOx conversion for K‐Fe/ZrO2 catalyst was <80% across the whole temperature range, and the catalyst was completely deactivated at ≈400 °C. As expected, the Fe/ZrO2‐W catalyst exhibited a much superior anti‐K‐performance in comparison to the Fe/ZrO2 catalyst. The active temperature window for K‐Fe/ZrO2‐W catalyst was 285–485 °C (NOx conversion of >80%).CONCLUSIONAccording to the characterization results, it was found that K‐species impose a negative impact on NH3 adsorption on the surface of the Fe/ZrO2 catalyst, especially drastically preventing the adsorption of NH3 species on Brønsted acid sites, thus inhibiting the occurrence of SCR reactions via the Langmuir–Hinshelwood (L‐H) mechanism. By contrast, W modification resulted in more chemisorbed oxygen, stronger redox capacity and an increased Fe3+/(Fe3++Fe2+) ratio on the surface of the Fe/ZrO2‐W catalyst. More importantly, W modification brought about abundant Brønsted acid sites, significantly promoting NH3 adsorption and activation. W modification also weakened the adsorption stability of NOx species to a certain extent. As a result, SCR reactions over the Fe/ZrO2‐W catalyst could proceed via both Eley–Rideal (E‐R) and L‐H pathways. © 2023 Society of Chemical Industry (SCI).
Microstructural alterations in hypoxia‐related BRAIN centers after COVID‐19 by using DTI: A preliminary study
Authors: Balsak Serdar , Atasoy Bahar , Donmez Zeynep , Yabul Fatma Celik , Daşkaya Hayrettin , Akkoyunlu Yasemin , Yurtsever İsmail , Sarı Lütfullah , Sijahovic Samira , Akcay Ahmet , Toluk Ozlem , Alkan Alpay 
Published: June 2023

AbstractPurposeTo investigate whether the diffusion tensor imaging (DTI) parameters alterations in the in hypoxia‐related neuroanatomical localizations in patients after COVID‐19. Additionally, the relationship between DTI findings and the clinical severity of the disease is evaluated.MethodsThe patients with COVID‐19 were classified into group 1 (total patients, n = 74), group 2 (outpatient, n = 46), and group 3 (inpatient, n = 28) and control (n = 52). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were calculated from the bulbus, pons, thalamus, caudate nucleus, globus pallidum, putamen, and hippocampus. DTI parameters were compared between groups. Oxygen saturation, D dimer and lactate dehydrogenase (LDH) values associated with hypoxia were analyzed in inpatient group. Laboratory findings were correlated with ADC and FA values.ResultsIncreased ADC values in the thalamus, bulbus and pons were found in group 1 compared to control. Increased FA values in the thalamus, bulbus, globus pallidum and putamen were detected in group 1 compared to control. The FA and ADC values obtained from putamen were higher in group 3 compared to group 2. There was a negative correlation between basal ganglia and hippocampus FA values and plasma LDH values. The ADC values obtained from caudate nucleus were positively correlated with plasma D Dimer values.ConclusionADC and FA changes may reveal hypoxia‐related microstructural damage after COVID‐19 infection. We speculated that the brainstem and basal ganglia can affected during the subacute period.
Malnutrition defined by GLIM criteria identifies a higher incidence of malnutrition and is associated with pulmonary complications after oesophagogastric cancer surgery, compared to ICD‐10‐defined malnutrition
Authors: Murnane Lisa C. , Forsyth Adrienne K. , Koukounaras Jim , Shaw Kalai , King Susannah , Brown Wendy A. , Mourtzakis Marina , Tierney Audrey C. , Burton Paul R. 
Published: June 2023

AbstractBackground & ObjectivesLow muscle mass, measured using computed tomography (CT), is associated with poor surgical outcomes. We aimed to include CT‐muscle mass in malnutrition diagnosis using the Global Leadership Initiative on Malnutrition (GLIM) criteria, compare it to the International Classification of Diseases 10th Revision (ICD‐10) criteria, and assess the impact on postoperative outcomes after oesophagogastric (OG) cancer surgery.MethodsOne hundred and eight patients who underwent radical OG cancer surgery and had preoperative abdominal CT imaging were included. GLIM and ICD‐10 malnutrition data were assessed against complication and survival outcomes. Low CT‐muscle mass was determined using predefined cut‐points.ResultsGLIM‐defined malnutrition prevalence was significantly higher than ICD‐10‐malnutrition (72.2% vs. 40.7%, p < 0.001). Of the 78 patients with GLIM‐defined malnutrition, low muscle mass (84.6%) was the predominant phenotypic criterion. GLIM‐defined malnutrition was associated with pneumonia (26.9% vs. 6.7%, p = 0.010) and pleural effusions (12.8% vs. 0%, p = 0.029). Postoperative complications did not correlate with ICD‐10 malnutrition. Severe GLIM (HR: 2.51, p = 0.014) and ICD‐10 (HR: 2.15, p = 0.039) malnutrition were independently associated with poorer 5‐year survival.ConclusionsGLIM criteria appear to identify more malnourished patients and more closely relate to surgical risk than ICD‐10 malnutrition, likely due to incorporating objective muscle mass assessment.
Untersuchung von Prozesskontaminanten und Chlorogensäuren in Arabica Röstkaffee.
Authors: Delker Ulf , Engelhardt Ulrich 
Published: June 2023

Durch die Röstung von Kaffee kommt es neben der Bildung von Verbindung die das typische Kaffeearoma ausmachen auch zur Bildung unerwünschte Stoffe wie Acrylamid, Furan, 2‐ und 3‐Methylfuran, 2,5‐Dimethylfuran (Methylfurane). Das Ziel der vorliegenden Arbeit war es, Behandlungsverfahren und Röstparameter zu identifizieren, welche eine gleichzeitige Minimierung von Acrylamid und Furan/Methylfuranen ermöglichen.Dazu wurde Brazil Arabica Rohkaffee unter Variation der Zeit und der Temperatur auf die Röstgrade hell, mittel und dunkel geröstet. Die hergestellten Röstkaffees wurden mit optimierten und validierten Methoden mittels GC‐MS auf die Gehalte der genannten Analyten untersucht. Durch die Untersuchungen konnte das gegenläufige Verhalten der Bildung von Acrylamid und Furan/Methylfuranen aufgezeigt werden. Die höchsten Gehalte an Acrylamid konnten in hellen sowie kurzen Röstungen nachgewiesen werden. Die höchsten Gehalte an Furan/Methylfuranen wurden in dunklen und langen Röstungen ermittelt. Auch extreme Röstprofile und Vorbehandlungsverfahren (Dämpfung, Entcoffeinierung) ergaben zwar unterschiede, das gegenläufige Verhalten der beiden Gruppen war aber weiterhin gegeben. Insgesamt konnten keine Röstparameter ermittelt werden, mit denen eine gleichzeitige Minimierung von Acrylamid und Furan/Methylfuranen möglich ist.Die Röstkaffees wurden auf ihre Gehalte an Chlorogensäuren (CQA), einer sehr wichtigen Verbindungsklasse in Kaffee, untersucht. Chlorogensäuren sind antioxidativ wirksame Verbindungen. Anhand der untersuchten Kaffees konnte der Röstgrad als größter Einflussfaktor für das Ausmaß des CQA‐Abbaus identifiziert werden. Kaffees die einer Vorbehandlung unterzogen wurden wiesen höhere CQA‐Gehalte auf als die Referenzröstungen. Die übrigen Röstexperimente zeigten keinen eindeutigen Trend.
A Strong and Double‐sided Self‐Adhesive Hydrogel Sensor
Authors: Xu Rongnian , Lai Yingying , Liu Jianping , Wei Qiangbing , Sheng Wenbo , Ma Shuanhong , Lei Ziqiang , Zhou Feng 
Published: June 2023

AbstractFlexible self‐adhesive hydrogel sensors are attracting considerable concerns in recent years. However, creating a self‐adhesive hydrogel sensor with excellent mechanical properties remains to be challenging. Herein, a double‐sided self‐adhesive hydrogel capable of strain sensor with high strength is demonstrated by penetration strategy. The middle poly(acrylic acid)‐polyacrylamide/Fe3+ (PAA–PAM/Fe3+) tough layer endows the double‐sided self‐adhesive hydrogel with high mechanical properties, while the bilateral poly[2‐(methacryloyloxy) ethyl]dimethyl‐(3‐sulfopropyl)ammonium hydroxide‐polyacrylamide (PSBMA–PAM) adhesive layers are used to ensure excellent adhesiveness on diverse substrates. The tough layer of the double‐sided self‐adhesive hydrogel sensor shows a strong interface bonding force against the adhesive layer. The double‐sided self‐adhesive hydrogel sensor enables excellent adhesiveness on diverse substrates. More importantly, it can accurately detect different strains and human motions as a self‐adhesive hydrogel strain sensor. This work manifests a new route of structural design to develop a self‐adhesive hydrogel sensor with excellent mechanical properties that is suitable for a wide range of applications.
Internationalisation, employment generation and wage premia: evidence from Indian manufacturing firms
Authors: Aggarwal Anshul , Sharma Chandan 
Published: June 2023

AbstractThe study investigates the impact of internationalisation on employment and wages in the Indian manufacturing sector by using an extensive plant‐level dataset. Using system generalised method of moments (GMM) and quantile regression estimators, we find strong evidence of the dampening effect of exports and imports on wages, whereas a positive impact of foreign investment on wages. However, the magnitude of the impact of internationalisation on wages reduces marginally at higher quantile levels. The impact of imports and exports on employment generation is slightly ambiguous though overall indicates a beneficial impact.
A wideband bandpass filter with wide upper stopband attenuation containing multiple resonators
Authors: Bai Lei , Zhuang Yi‐qi , Zeng Zhi‐bin 
Published: June 2023

AbstractA compact wideband bandpass filter with a wide passband and very‐wide out‐of‐band suppression is presented. The filter is constructed from a central rectangular‐ring resonator with two open stubs placed around it symmetrically. In addition, tri‐section stepped‐impedance resonators are symmetrically distributed on both sides of the two open stubs, and two symmetrical funnel‐shaped resonators are included to enhance out‐of‐band suppression. The out‐of‐band performance of filter is very good, with a suppression level greater than 20 dB up to 25.72 GHz. The center frequency of the filter is 5.84 GHz, with a fractional bandwidth of 115.8%. Good agreement between the simulations and measurements validates the design principle.
Insights into the effects of high‐temperature lubricating oils on the aging behavior and degradation mechanism of fluoroelastomers
Authors: Wang Shengqiang , Wang Cunguo , He Aihua 
Published: June 2023

AbstractThe aging behavior and degradation mechanism of fluoroelastomers (FKM) after exposure to thermal air, commercial lubricating oil, and the corresponding base oil at elevated temperatures were investigated. The FKMs immersed in oil and exposed to air are denoted by FKM‐O and FKM‐A, respectively. The crosslinking densities of the samples were determined by equilibrium swelling and dynamic mechanical analyses, and the results were different. Compared to the performances of FKM‐A, noticeable changes in the mechanical and swelling performances of FKM‐O were observed, attributed to the severe deterioration induced by both the lubricating oil and the high‐temperature. The FTIR results revealed that the dehydrofluorination induced by the oil caused the fracture of the CF bonds, and the degradation of the oil itself exerted negative impacts on the properties of the FKM. The findings of this study will facilitate the development of FKMs with degradation‐resistant properties for various applications.
Influence of an electric‐field on the topological stability of the neutral lithium dimer
Authors: Feng Xinxin , Azizi Alireza , Xu Tianlv , Yu Wenjing , Mi Xiaopeng , Lu Hui , Früchtl Herbert , van Mourik Tanja , Kirk Steven R. , Jenkins Samantha 
Published: June 2023

AbstractIn this investigation, we seek to understand the role of non‐nuclear attractors (NNAs) of the neutral Li2dimer subjected to an electric (±E) field that is directed parallel (±Ex) and perpendicular (±Ey) to the bond‐path. The±Ex‐fields and±Ey‐fields are separately applied to the Li2molecular graph until the bond ruptures. The next generation quantum theory of atoms in molecules (NG‐QTAIM) interpretation of bonding was constructed with the stress tensorσ(r) eigenvectors on the Hessian ofρ(r) molecular graph. The asymmetry induced by both the±Ey‐field and±Ex‐field was detected in terms of the rotation of the orthogonal triad of stress tensorσ(r) eigenvectors {e1σ,e2σ,e3σ} relative to the Cartesian coordinate frame. The orthogonal triad of Hessian ofρ(r) eigenvectors {e1,e2,e3} however, were only able to detect rotation induced by the high degree of asymmetry present for bent bond‐paths induced by the±Ey‐fields. Larger movement of theNNAs along the bond‐path correlated with greater bond critical point (BCP) bond metallicity ξ(rb). The effect of applying the±Ex‐field was compared with unpublished results on neutral Li2subject to a stretching distortion. The lack ofNNAmotion along the bond‐path for the stretching distortion correlated with a lower degree of bond metallicity ξ(rb). The stress tensorσ(r) eigenvectors have a unique ability to detect rotation relative to the Cartesian coordinate frame for high bond‐path symmetry occurring for the bond‐stretching distortion and application of the±Ex‐field. Suggestions for future work are provided.
Adaptive quantized control for a class of high‐order nonlinear systems
Authors: Li Guangqi 
Published: June 2023

AbstractIn this article, the adaptive stabilization problem is addressed for a class of nonlinearly parameterized systems with quantized input. The quantizer parameters and virtual control coefficients are unknown, and the linearization of the nonlinear systems is uncontrollable. A novel nonlinear time‐varying model is proposed to deal with the quantized input. Through the proposed nonlinear model, the quantized adaptive control problem is converted into the adaptive stabilization problem for nonlinear high‐order system with unknown virtual control coefficients. Then, based on the tuning function approach and adding power integrator technique, adaptive laws and an adaptive state feedback controller are designed. Further, it is shown that by adjusting some design parameters, the proposed scheme enables the stabilization error converges to an arbitrarily small neighborhood of the origin. Simulation is also provided to verify the validity of proposed scheme.