bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Collision-Free Guidance and Control for Fully Actuated Multirotor Aerial Vehicles
Authors: Junior Jorge Antonio Ricardo , Santos Davi Antônio dos 
Published: May 2023

Abstract
This paper is concerned with the robust guidance and control of fully actuated multirotor aerial vehicles in the presence of moving obstacles, linear velocity constraints, and matched model uncertainties and disturbances. We address this problem by adopting a standard hierarchical flight control architecture consisting of a supervisory outer-loop guidance module and an inner-loop stabilizing control one. The position and attitude control laws are designed using a proportional-derivative approach combined with a high-order sliding mode disturbance observer. On the other hand, we propose a robust guidance strategy based on the continuous-control-obstacles method in order to drive the vehicle to a target pose while avoiding collision with moving obstacles and violation of linear velocity constraints. The overall method has been numerically evaluated and shown to be effective in providing satisfactory tracking performance, collision-free guidance, and satisfaction of linear velocity constraints. Furthermore, it outperformed another method that designs the guidance and control strategies using continuous-control-obstacles and a smooth first-order sliding mode control, respectively.
A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products
Authors: Tan Zaigao , Li Jian , Mu Xin , Dong Wenyue , Chen Yun , Kang Qianjin , Zhao Guang , Hou Jin , Gonzalez Ramon , Bai Linquan , Feng Yan , Yang Chen , Liu Tiangang 
Published: May 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Prevalence and factors associated with flares following COVID-19 mRNA vaccination in patients with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: a national cohort study
Authors: Fong Warren , Woon Ting Hui , Chew Li-Ching , Low Andrea , Law Annie , Poh Yih jia , Yeo Siaw Ing , Leung Ying Ying , Ma Margaret , Santosa Amelia , Kong Kok Ooi , Xu Chuanhui , Teng Gim Gee , Mak Anselm , Tay Sen Hee , Chuah Tyng Yu , Roslan Nur Emillia , Angkodjojo Stanley , Phang Kee Fong , Sriranganat Melonie , Tan Teck Choon , Cheung Peter , Lahiri Manjari 
Published: May 2023

Abstract
Objective
To determine prevalence and factors associated with flares post Coronavirus disease 2019 (COVID-19) mRNA vaccination in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA).
Methods
A retrospective multi-centre study was conducted (January 2021 to February 2022). Data were collected during index visit, defined as first post-vaccine visit in which the patient had a physician-defined flare, or if at least three months had elapsed since first vaccine dose, whichever came first. Factors associated with flares were identified using mixed effects Cox regression and expressed as hazard ratio (HR) and 95% confidence interval (CI).
Results
Total of 2377 patients were included (1563 RA, 415 PsA and 399 SpA). Among patients with RA, PsA and SpA, 21.3%, 24.1% and 21.8% experienced a flare respectively. Of those who experienced a flare, only 10.2%, 11.0% and 14.9% were severe in patients with RA, PsA and SpA respectively. Patients with low or moderate/ high disease were more likely to flare compared to those in remission in patients with RA only (HR: 1.68, 95% CI: 1.22 – 2.31; HR: 2.28, 95% CI: 1.50 – 3.48, respectively). Receiving the Moderna vaccine was associated with a higher HR of flare compared to the Pfizer vaccine in patients with PsA only (HR: 2.21, 95% CI: 1.20 – 4.08). Patients who had two vaccine doses were found to be less likely to flare (HR: 0.08, 95% CI: 0.06 – 0.10). HRs of flares were not significantly different among RA, PsA and SpA.
Conclusion
About one-fifth of patients experienced a disease flare post COVID-19 mRNA vaccination, but most flares were non-severe. Patients with active disease prior to vaccination should be monitored closely for disease flares, especially in patients with RA.
Atomically-precise engineering of spin-orbit polarons in a kagome magnetic Weyl semimetal
Authors: Gao Hong-Jun , Chen Hui , Xing Yuqing , Tan Hengxin , Huang Li , Zheng Qi , Huang Zihao , Han Xianghe , Hu Bin , Ye Yuhan , Li Yan , Xiao Yao , Lei Hechang , Qiu Xianggang , Liu Enke , Yang Haitao , Wang Ziqiang , Yan Binghai 
Published: May 2023

Abstract
Atomically-precise engineering of defects in topological quantum materials, which is essential for constructing new artificial quantum materials with exotic properties and appealing for practical quantum applications, remains challenging due to the hindrances in modifying complex lattice with atomic precision. Here, we report the atomically-precise engineering of the vacancy-localized spin-orbital polarons (SOP) in a kagome magnetic Weyl semimetal Co3Sn2S2, using scanning tunneling microscope. We achieve the repairing of the selected single vacancy and create atomically-precise sulfur quantum antidots with elaborate geometry through vacancy-by-vacancy repairing. We find that that the bound states of SOP experience a symmetry-dependent energy shift towards Fermi level with increasing vacancy size driven by the anti-bond interactions. Strikingly, as vacancy size increases, the localized magnetic moments of SOPs are tunable and ultimately extended to the negative magnetic moments resulting from spin-orbit coupling in the kagome flat band. These findings establish a new platform for engineering atomic quantum states in topological quantum materials, offering potential for kagome-lattice-based spintronics and quantum technologies.
Disruption to Schooling Impedes the Development of Abstract Reasoning and Theory of Mind in Children
Authors: Alan Sule , Turkum Betul 
Published: May 2023

Abstract
We show that the development of abstract reasoning and cognitive empathy (theory of mind) is severely hindered when children are deprived of the stimulation of a school environment. We document significantly lower abstract reasoning and cognitive empathy scores in elementary school children who returned from an extended school closure caused by the Covid-19 pandemic relative to proximate pre-pandemic cohorts. This developmental delay has a significant socioeconomic gradient, with underprivileged children experiencing more substantial delays. We also document a significant disruption in the development of socioemotional skills: 0.24 sd lower grit, 0.43 sd lower emotional empathy, 0.06 sd lower epistemic curiosity, and 0.24 sd higher impulsivity. About eight months of school exposure results in a remarkable recovery in abstract reasoning and theory of mind for all socioeconomic groups. However, the measured levels still indicate significant delays relative to the expected developmental trajectories. No notable improvements are observed in socioemotional skills except for curiosity. These findings reveal that the damage school closures inflicted on children goes beyond well-documented academic losses and highlight the crucial role of the school environment in fostering fundamental cognition and socioemotional development in children.
Does stringent environmental regulations influence export performance in a low technical capacity economy? A quasi-natural experiment based on Kenya’s new environmental protection law
Authors: Akama Erick Maiko 
Published: May 2023

Abstract
As the environment continues to become increasingly constrained, the relationship between environmental protection and economic growth is becoming a crucial subject. This study considered Kenya’s new environmental regulation laws on emission control as a "quasi-natural experiment" to assess the impact of stringent environmental regulations of emission control on industrial’ export performance using a difference-in-differences (DID) framework. The study uses a panel data of 137 firms from the Export Processing Zone (EPZ) and Pooled OLS analysis with agricultural food industry as the control group. The heterogeneous impacts of firms with different size level is investigated. The study reveals that stringent environmental regulations of emission control enhances export intensity among the EPZ firms. Micro firm’s export intensity gains the highest (18.21 %,) from stringent environmental regulations on emission control than both small (11.09%) and large firms (9.50%). The study also found a significant association between export performance and firm ownership status, location and experience in exporting. The study thus recommends applicability of stringent environmental regulation in achieving both export performance and environmental improvement in Kenya.
Pilot-scale genome-wide association mapping in diverse sorghum germplasms identified novel genetic loci linked to major agronomic, root and stomatal traits
Authors: Ramalingam Ajay Prasanth , Mohanavel Williams , Kambale Rohit , Rajagopalan Veera Ranjani , Elangovan Allimuthu , Karnatam Krishna Sai , Marla Sandeep R , Prasad P. V. Vara , Muthurajan Raveendran , Perumal Ramasamy 
Published: May 2023

Abstract
This genome-wide association studies (GWAS) used a subset of 96 diverse sorghum accessions, constructed from a large collection of 219 accessions for mining novel genetic loci linked to major agronomic and physiological traits including root. The subset yielded 43,452 high quality single nucleotide polymorphic (SNP) markers exhibiting high allelic diversity. Population stratification showed distinct separation between caudatum and durra races. Linkage disequilibrium (LD) decay was rapidly declining with increasing physical distance across all chromosomes. The initial 50% LD decay was ~ 5Kb and background level was within or below ~ 80Kb. Plant height and grain color identified significant SNPs co-localized with dwarfing dw2 locus and chalcone synthase, respectively, indicating the representativeness of the population and reliability of methods. AP2-like ethylene-responsive transcription factor and gibberellin receptor GID1L2 affecting single plant yield and biomass respectively were identified. The study detected novel genetic loci linked to drought avoidance traits viz., Leucine rich repeat family protein (root biomass and root architecture), AP2 domain containing protein (intrinsic water use efficiency) and serine/threonine protein kinase (abaxial stomatal complex total area). This study justified that the constructed subset of diverse sorghums can be used as a panel for mapping other key traits to accelerate molecular breeding in sorghum.
The SIR epidemic model with diffusion and nonlinear incidence: a symmetry approach
Authors: Naz R , Johnpillai A , Mahomed F 
Published: May 2023

Abstract

We use Lie point symmetries to obtain reductions and group-invariantsolutions for the diffusive SIR epidemic model with diffusion andnonlinear incidence. We determine that the Lie algebra for thismodel is three-dimensional. We invoke these to establish group-invariantsolutions of the diffusive SIR model. The conservation laws are determined via the multiplier approach.
Predictive value of preoperative platelet count and D-dimer levels for spinal cord injury following acute type A aortic dissection
Authors: Pei Fengbo , wei jinhua , yao yao , wu hui , Chen zujun 
Published: May 2023

Abstract
Background This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).Methods This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD and underwent total arch replacement with the deep hypothermic circulatory arrest at Fuwai Hospital between September 2016 and April 2020.Results The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] 0.774) and D-dimer levels (OR 2.247) held potential as independent predictors for postoperative SCI in patients diagnosed with TA-AAD.Conclusion The study results indicated that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in individuals with TA-AAD. This finding holds significance regarding clinical implications for prognosis and therapeutic responses in TA-AAD.
Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization
Authors: Zeng Suping , Yu Longhua , He Ping , Li Yueqiao , Feng Hui , Wang Jia , Zhang Huacong , Song Yunxia , Liu Ren 
Published: May 2023

Abstract

BackgroundNitrogen (N) is very important for plant development, growth, and secondary metabolism.Lithocarpus polystachyusRehd, also called sweet tea, is known for its medicinal and food value. It contains several bioactive components, including phlorizin, with various pharmacological activities. Research has indicated a positive correlation between phlorizin and nitrogen (N) content inL. polystachyus.However, no reports have analyzed the effect of N treatment on phlorizin content and and reveal the molecular mechanisms of phlorizin synthesis.ResultsWe grewL. polystachyuswithout and with N fertilization at six levels (0, 25, 75, 125, 175, 225, and 275 mg per plant) and analyzed the plant growth status and leaf phlorizin content. These initial experiments revealed that 75 mg N/plant resulted in the best seedling height, ground diameter, crown width, and total phlorizin content inL. polystachyus. Subsequent comparison ofL. polystachyusplants grown without and with 75 mg/plant N fertilization identified 150 differentially accumulated metabolites in the leaves, including 42 flavonoids, using ultra-performance liquid chromatography-tandem mass spectrometry. Transcriptomic analysis by RNA sequencing detected 162 genes involved in flavonoid biosynthesis, among which 53 were significantly different between N-treated and untreated materials. Fertilization (75 mg N/plant) upregulated the expression levels of phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL), and phlorizin synthase (PGT1) but downregulated those of trans-cinnamate 4-monooxygenase (C4H) and chalcone isomerase (CHI), were related to the phlorizin synthesis. Integrated analysis of the transcriptome and metabolome found that the increase in phlorizin via the flavonoid biosynthetic pathway after N fertilization was consistent with the the expression levels upregulation of phlorizin biosynthetic genes. Quantitative real-time PCR (qRT-PCR) analysis validated the RNA-sequencing data. Thus, these observations indicated that the expression levels ofPAL,PGT1, 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase (C3'H),C4H, and shikimate O-hydroxycinnamoyltransferase (HCT) genes were related to phlorizin metabolism inL. polystachyusunder N fertilization.ConclusionsOverall, understanding the molecular mechanism of phlorizin synthesis will help improve plant quality and serve as a reference for further pharmacological studies.
Reference-free and cost-effective automated cell type annotation with GPT-4 in single-cell RNA-seq analysis
Authors: Ji Zhicheng , Hou Wenpin 
Published: May 2023

Abstract
Cell type annotation is an essential step in single-cell RNA-seq analysis. However, it is a time-consuming process that often requires expertise in collecting canonical marker genes and manually annotating cell types. Automated cell type annotation methods typically require the acquisition of high-quality reference datasets and the development of additional pipelines. We demonstrate that GPT-4, a highly potent large language model, can automatically and accurately annotate cell types by utilizing marker gene information generated from standard single-cell RNA-seq analysis pipelines. Evaluated across hundreds of tissue types and cell types, GPT-4 generates cell type annotations exhibiting strong concordance with manual annotations, and has the potential to considerably reduce the effort and expertise needed in cell type annotation.
Feeling Uncertain During Lockdown: Exploring Emotional Experience among Adolescents amidst Covid-19
Authors: Amran Muhammad Syawal , Sahuri Sarifah Nurhanum Syed , Marzuki Maziah Ahmad 
Published: May 2023

Abstract

An outbreak of global pandemic influences adolescents’ emotional well-being and contributes to psychosocial conflict. Detecting adolescents’ emotion when they stay at home during Pandemic COVID-19 may be helpful to better understand their well-being. Therefore, the current study aimed to explore adolescents' emotional well-being in the midst of the outbreak. This study employs a qualitative method for participants’ interview (n=30) among adolescents from low -income households. This study was conducted for six weeks during the midst of the outbreak. The qualitative data were collected via online based on focus group discussions and semi-structured interviews. The results reveal that boredom, anxiety and hope were the main emotions faced by the adolescents’ in the midst of the outbreak. This finding explains that they were extremely bored repeating the same routines and not being able to interact with their friends physically. Alongside, they felt anxious about learning progress that may affect their academic performance, uncertain pandemic COVID-19 situation and family’s economic crisis. The adolescents also illustrated a green shoot of hope to return to school and that the number of pandemic cases will be rapidly reduced. Overall study emphasizes that emotions are important factors that can be addressed in order to prevent emotional fatigue and mental health problems that affect adolescents’ social well-being. This study hints at a novel research area for psychologists to develop emotional preparedness strategies for adolescents to help parents and teachers in order to improve emotional management skills at home. Future research should comprehensively measure the impact of emotion and its relation to behavioral problem during outbreaks.
Experimental study on characterization of lime-based mineral carbonation reaction and CO2 sequestration
Authors: Karaca Zeki 
Published: May 2023

Abstract
This paper reports for the first time the use and application of a novel technique in the characterization of mineral carbonation reaction and CO2 sequestration in soil stabilization using flow meters. Soils based on SiO2 with two different sizes were tested. Lime (Ca(OH)2) was used as the reactant. Instant CO2 flow rate (L/min), total CO2 volume (L), temperature (°C), and absolute pressure (kPa) were monitored and recorded for 1 hour by flow meters connected to the mold inlet and outlet. It was determined that the mineral carbonation reaction started in the first seconds and ended before the 5th minute. The mineral carbonation is a short-term and potential reaction, and it is not a time-dependent reaction. It is separated from other carbonation reactions with these characteristics. The highest CO2 captured value was obtained in the soil mixed with 5% lime, where fines were not used. The second highest CO2 captured value was obtained in soil mixed with 1% lime, where fines were not used. CO2 captured with 1% lime is more than CO2 captured with 5% lime in the soil containing fines. Accordingly, 1-5% lime can be used in soil carbonation studies. According to the soil properties, the highest CO2 captured and the CO2 efficiency was achieved with the use of 6-7% water by weight.
Life cycle energy, climate, and economic assessment of technologies for bioresource production from wastewater
Authors: Hoek Eric , Clack Kevin , Rajagopal Deepak 
Published: May 2023

Abstract

Thermochemical conversion technologies present an opportunity to flip the paradigm of wastewater biosolids management operations from energy-intense and expensive waste management processes into energy-positive and economical resource extraction centers. Herein, we present a uniform “grading framework” to consistently evaluate the environmental and commercial benefits of established and emerging wastewater biosolids management processes from a life cycle and techno-economic perspective. Application of this approach reveals that established wastewater biosolids management practices such as landfilling, land application, incineration and anaerobic digestion, while commercially viable, offer little environmental benefit. On the other hand, emerging thermochemical bioresource recovery technologies such as hydrothermal liquefaction, gasification, pyrolysis, and torrefaction show potential to provide substantial economic and environmental benefit through the recovery of carbon and nutrients from wastewater biosolids in the form of biofuels, fertilizers, and other high-value products. Some emerging thermochemical technologies have developed beyond pilot scale although their commercial viability remains to be seen.
Mental Health Related Stigma in Romania: Systematic Review and Narrative Synthesis
Authors: Manescu Elena Andreea , Henderson Claire , Paroiu Ciprian R. , Mihai Adriana 
Published: May 2023

Abstract
Background: Stigma related to mental illness is increasingly and more effectively addressed. Although more research is being conducted, there is relatively little from low and middle-income countries, with former Soviet bloc countries identified as a particular contributor to this evidence gap. Romania struggles with mental health stigma at many levels. The aim of this review was to bring together all relevant data regarding stigma and discrimination related to mental illness as well as actions to address these problems in Romania in order to prioritise further stigma research and identify priority targets for stigma reduction.
Methods: A systematic literature search was conducted in three online databases and grey literature. After the analysis of full manuscripts, four were excluded based on lack of relevance or incomplete data reporting. Quality assessment was performed for included studies using STROBE guidelines and the narrative was synthesized based on the research questions.
Results: The review included fifteen studies, the majority having a cross-sectional design. Stigma related to mental illness in Romania, has an impact on help-seeking attitudes and behaviours, workplace environment and social relationships of people with mental health problems. Negative stereotypes are maintained and validated by mass media reports. Significant stigma in healthcare and mental care settings has also been observed. Self-stigma was less frequently reported than public stigma. Despite a few stigma reduction actions, no rigorous evaluation of content, delivery and effectiveness has been conducted and no empirical evidence has been published.
Conclusions: Based on this review, three lines of action are recommended in Romania. Increase research concerning stigma in healthcare and mental care settings and use behavioural outcomes. Develop and deliver evidence-based tailored interventions to reduce stigma in identified priority subgroups of the population and ensure rigorous evaluation and scientific dissemination. Elaborate guidelines for working with community stigma and advocate for structural changes.