bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ M2 Bypass for Treatment of Fusiform Middle Cerebral Artery Bifurcation Aneurysm: Technical Case Instruction and Operative Video
Authors: Jabarkheel Rashad , Muhammad Najib , Blue Rachel , Ajmera Sonia , Davis Pierce , Vaz Alex , Srinivasan Visish M. , Burkhardt Jan-Karl 
Published: January 2025

BACKGROUND AND IMPORTANCE:
Fusiform middle cerebral artery (MCA) bifurcation aneurysms can be challenging to treat with standard endovascular or microsurgical techniques. The in situ side-to-side bypass technique represents an elegant revascularization option for these aneurysms when trapping becomes necessary.

CLINICAL PRESENTATION:
A man in his 50s presented for evaluation of an incidentally found fusiform, 10 mm, right MCA bifurcation aneurysm with involvement of both the inferior and superior M2 trunks. Plan was initially made for a right pterional craniotomy for trapping of the aneurysm with exclusion of the inferior M2 trunk, preservation of the superior M2 trunk, with superficial temporal artery bypass to the inferior M2 trunk. Intraoperatively, after arachnoid dissection, it became clear that the distal superior and inferior M2 branches would lie in close approximation without tension, thus superficial temporal artery-M2 bypass was deferred, and instead in situ side-to-side M2 bypass was performed. Here in our operative video, we highlight the critical steps of in situ side-to-side M2 bypass technique.

CONCLUSION:
We present a technical case instruction and operative video highlighting the in situ side-to-side bypass technique for treatment of a large fusiform MCA bifurcation aneurysm.
Mitochondrial phosphatase PPTC7 promotes EGFR recycling by facilitating VPS4A endosomal localization
Authors: Baroi Rahul , Ahmad Reshi Hilal , Maddika SubbaReddy 
Published: January 2025

ABSTRACT
PPTC7 is a mitochondrial phosphatase that is essential for mitochondrial biogenesis, metabolism, protein content maintenance and transport. Although the mitochondrial roles of PPTC7 are well characterized, its roles outside the mitochondria are unclear. Here we identified a non-mitochondrial role for PPTC7 in regulating epidermal growth factor receptor (EGFR) trafficking. PPTC7 interacts with and dephosphorylates VPS4A, a crucial ESCRT and multivesicular body-associated protein. We found that PPTC7-mediated dephosphorylation of VPS4A at serine 335 is required for VPS4A stability and its early endosomal localization. Either loss of PPTC7 or presence of constitutively phosphorylated VPS4A led to defective recycling of EGFR, thus leading to EGFR re-routing to lysosomes for degradation. Further, we demonstrate that PPTC7–VPS4A-dependent EGFR recycling promotes the AKT signaling pathway, thus enhancing cell proliferation and migration. Overall, our studies unveil an important mechanism where the PPTC7–VPS4A complex orchestrates an endosomal switch to promote EGFR recycling.
A Two-Stage Iteration Method for Solving the Departure Time Choice Problem
Authors: Guo Ren-Yong , Yang Hai , Huang Hai-Jun 
Published: January 2025

We discuss the numerical solution of the departure time choice problem. The non–quasi-monotone of the travel cost vector function is first proved to address the study motivation. A two-stage iteration method is then proposed to effectively solve the problem in a single origin-destination (OD) pair network with parallel links, in which departure time and route choices of commuters are involved. We analytically reveal why the iteration method can solve the problem and theoretically prove the convergence, that is, the iteration process finally achieves at a user equilibrium (UE) state. The iteration method is then extended to a single link network with heterogeneous users in the values of travel time and schedule delay and the preferred arrival time. Furthermore, numerical analyses are conducted for the two networks to demonstrate the effectiveness of the iteration method for solving the departure time choice problem. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72288101, 72171007, and 72021001]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2024.0599 .
Henry Garrett: Raça e Integração Escolar nos Estados Unidos no pós-II Guerra Mundial
Authors: Munareto Geandra Denardi , Boarini Maria Lúcia 
Published: January 2025

O presente texto objetiva analisar a persistência das noções de raça no contexto do pós-Segunda Guerra Mundial a partir das ideias do psicólogo estadunidense Henry Garrett (1894-1973). Para isso, utilizamos como fonte seus trabalhos publicados, bem como as transcrições dos depoimentos onde foi convidado a dar seu parecer sobre a questão da separação das instituições de ensino. Tal estudo se justifica tanto pela trajetória acadêmica de Garrett como pela sua participação destacada nos julgamentos que levaram a Suprema Corte dos Estados Unidos a decretar o fim da segregação escolar no país em 1954 e nas sucessivas tentativas de reverter a nova legislação, de forma a impedir a integração racial nos espaços públicos, estabelecido pelas leis Jim Crow. Colocando-se como defensor da separação das escolas, Garrett empregou seu conhecimento para argumentar que a criação de colégios racialmente mistos traria prejuízos para os alunos, devido à grande disparidade de inteligência e personalidade apresentados entre eles.
Avaliação do estilo de vida e da autoestima de profissionais de enfermagem hospitalar
Authors: Santos Sergio Valverde Marques dos , Silva Luiz Almeida da , Ribeiro Beatriz Maria dos Santos Santiago , Alves Leslie Diniz , Dalri Rita de Cássia Marchi Barcelos , Robazzi Maria Lucia do Carmo Cruz 
Published: January 2025

Objetivo: avaliar a correlação entre o estilo de vida e a autoestima, e suas associações com os fatores sociodemográficos, epidemiológicos e laborais dos profissionais de enfermagem. Método: estudo transversal, desenvolvido com 289 trabalhadores de um hospital localizado no Sudoeste Minas Gerais, utilizando-o Questionário de Estilo de Vida Fantástico e Escala de Autoestima de Rosenberg. Análise por meio do teste Qui-quadrado de Pearson e Coeficiente de Correlação de Person. Resultados: a maioria dos profissionais apresentou autoestima média e bom estilo de vida. Faixa etária, prática de atividade física e tempo de profissão na enfermagem apresentaram associação com a autoestima dos profissionais (p<0,05). Sexo, faixa etária, prática de atividade física, uso de bebida alcoólica, tipo de moradia e turno de trabalho tiveram associação com o estilo de vida (p<0,05). Autoestima apresentou correlação com o estilo de vida dos profissionais (p<0,05). Conclusão: observa-se a necessidade de mudanças no estilo de vida desses trabalhadores, assim como a promoção de ações que favoreçam uma autoestima adequada.
60 anos do golpe de 1964 | Entrevista com Marcos Napolitano
Authors: Napolitano Marcos 
Published: January 2025

Marcos Napolitano, professor de História na Universidade de São Paulo, discute os 60 anos do golpe de 1964, enfatizando a necessidade de confrontar ataques negacionistas que distorcem a história da ditadura. Ele alerta que, embora o debate sobre o golpe e a ditadura esteja presente, existe uma contradição entre esse discurso e a falta de uma política de memória institucional eficaz no Brasil. Napolitano vê a ausência de uma "Justiça de Transição" como um fator que contribui para a sensação de desinteresse pelo passado autoritário. Ele também avalia que, apesar do interesse dos estudantes, o ensino sobre a ditadura nas escolas é prejudicado pela pressão da extrema direita e pela falta de tempo e recursos curriculares. Napolitano defende que temas como autoritarismo e democracia deveriam ser abordados de forma mais integrada ao longo do currículo escolar, em vez de serem comprimidos ao final do Ensino Fundamental e Médio. Para ele, é essencial investir em uma política de memória robusta que transcenda governos e que integre a educação com a conscientização sobre as violências sociais e políticas na história brasileira, apesar das dificuldades atuais.
Chronic pulmonary aspergillosis in tea population of Assam
Authors: Selvasekhar Aishwarya , Nath Reema , Gogoi Gourangie , Borah Pronami 
Published: January 2025

Background
Chronic pulmonary aspergillosis (CPA) is a disease commonly caused by Aspergillus fumigatus and other Aspergillus species characterized by cavitary lung lesions. Tea garden population is an agrarian population of Assam, mostly associated with tea plantations. Assam is a major tea-producing state with 803 tea gardens producing approximately 50% of the total tea in India, of which 177 are present in the Dibrugarh district alone. Tuberculosis is common in tea garden workers. This community-based cross-sectional study in the tea garden community of Dibrugarh was done to find the prevalence of Aspergillus IgG antibodies and CPA cases in individuals with chronic respiratory symptoms.

Methodology and principal findings
Patients visiting 3 tea garden hospitals and 2 referral hospitals with chronic cough and/or haemoptysis, weight loss/fatigue, and other respiratory symptoms for a duration of 3 months or more were included in this one-year study. Serum samples were tested by Immunocap Phadia 200 for Aspergillus fumigatus-specific IgG antibodies. CPA cases were diagnosed based on clinical, radiological, and serological criteria. Out of 128 samples, seropositivity was seen in 41 (32.0%) patients (cutoff value: 27 mgA/l). Male preponderance (1.6:1) with a mean age of 41.9 (±15.69) was observed. Haemoptysis and fatigue were significant symptoms seen (p-values: 0.0086 and 0.0098, respectively). Aspergillus fumigatus-specific IgG antibody was found to be significantly high in 29 out of 76 patients (38.1%) with a history of tuberculosis. Amongst them, seropositivity with active TB was 5 out of 27 patients (18.5%), and seropositivity with post-TB was 24 out of 49 patients (48.9%). Chronic cavitary pulmonary aspergillosis was the predominant type (38.1%). Proven CPA (clinically, radiologically, and serologically positive) were 22 (17.1%, 95% CI 10.7%–26.0%), and possible CPA (clinically and serologically positive but without radiological data) were 19 (14.8%, 95% CI 8.9%–23.1%).

Conclusion
A high prevalence of CPA (60 per 100 000) was detected. High Aspergillus seropositivity of 48.9% was seen in the post-TB population. Aspergillus-specific IgG antibody testing is the only confirmatory method for diagnosing CPA, which is available in limited centres in India. Aspergillus seropositivity should be detected in post-TB patients presenting with chronic respiratory symptoms.
Understanding uptake of the COVID-19 vaccination among the homeless: A mixed methods evaluation
Authors: Phillips Grace , Racine Emmy , Naughton Anna Marie , Lane Julieann , Kearney Patricia M. 
Published: January 2025

Background
Ensuring effective access to vaccinations for people experiencing homelessness is crucial to protecting the health of a vulnerable, yet often overlooked population. Reaching this goal takes more than a one size fits all approach. This study evaluates how a dedicated health team collaborated with multiple agencies to register and deliver the COVID-19 vaccine to people experiencing homelessness.

Methods
This is a mixed methods study co-designed with the Adult Homeless Integrated Team, a multi-disciplinary team who work with local agencies to provide care to people experiencing homelessness in Cork, Ireland’s second largest city. Quantitative data collected at the point of vaccine registration described socio-demographics of the population. To explain the quantitative findings, eleven agencies involved in provision of homeless services were invited to participate in interviews. A manager in each of the agencies acted as a gatekeeper to clients. Interviews explored experiences with the pandemic and the delivery (staff) or receipt (clients) of the COVID-19 vaccine. Interviews were recorded and transcribed, transcriptions were thematically analysed.

Results
There were 728 vaccine doses administered to people experiencing homelessness during the first roll-out of vaccines; 401 first doses and 325 second doses. Of those who received a vaccine, the majority were male (76%), and more than half were Irish (55%). Ten semi-structured interviews, seven staff members and three clients, were conducted. There were three themes that provided further insights into the quantitative findings: Adapting to unprecedented times, Misinformation causing vaccine hesitancy and The importance of building relationships.

Conclusions
This study provides valuable insights into how a multidisciplinary approach resulted in a successful well received vaccination programme among a traditionally hard to reach group.
“They are not HIV treatments drugs; they are preventive drugs (PrEP)”. Experiences of PrEP uptake among vulnerable adolescent girls and young women in Tanzania
Authors: Mwakilasa Magreth Thadei , Mwijage Alexander , Mushy Stella , Amour Maryam , Sirili Nathanael , Maziku Evaline , Likindikoki Samwel , Balandya Emmanuel , Kwesigabo Gideon , Kidenya Benson , Mshana Stephen E. , Lyamuya Eligius , Mmbaga Blandina , Sunguya Bruno , Bartlett John 
Published: January 2025

Introduction
HIV poses a significant global health concern, affecting adolescents among other populations. This is attributed to various vulnerabilities including biological factors, gender inequalities and limited access to comprehensive sexual and reproductive health services in sub-Saharan Africa. In Tanzania, adolescent girls, and young women (AGYW) face double the risk of HIV infection compared to their male counterparts. The introduction of pre-exposure prophylaxis (PrEP) in early 2018 brought hope for changing the HIV cascade in the country. However, numerous challenges still hinder PrEP uptake. Therefore, this study explored experiences of PrEP uptake among vulnerable AGYW in Tanzania.

Methods
This study employed a phenomenological qualitative approach; 52 semi-structured interviews were carried out between May to November 2022 in the selected healthcare facilities in Tanzania. The study adopted inductive-deductive thematic analysis guided by the Social Ecological Model (SEM) to elicit the views of AGYW aged 15–24. Nvivo software was utilised to organise data.

Results
This study has uplifted barriers and facilitators on PrEP uptake among AGYW in Tanzania. The barriers are categorized at individual, interpersonal, and institutional levels. The individual level barriers included pre-requisites for initiating PrEP, disbelief in the effectiveness of PrEP, interference of refill hours with working hours, financial constraints, and adherence to the pills. The interpersonal level barriers included misconceptions about PrEP pills, and labelling of PrEP users. The institutional level barriers included inadequate privacy, PrEP drug stockout, being turned away by health care facilities (HCF), long waiting times, and distance to the HCF. Facilitators included factors at individual level (experienced benefit of PrEP, adequate PrEP knowledge, having multiple partners, perceived risk due to the nature of the work, PrEP ensuring privacy), interpersonal level (support from social networks), and institutional level (Free availability of PrEP, receiving refill reminders).

Conclusions
To overcome barriers to PrEP uptake among AGYW, it is crucial to develop multi-level interventions that consider personal, social, and structural factors hindering PrEP uptake. Implementing strategies like prioritizing off-site PrEP delivery and expanding community outreach for PrEP awareness can help dispel misconceptions and enhance uptake.
Comparative evaluation of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in infants after non-cardiac surgery: Study protocol of a randomized controlled trial
Authors: Zhang Diwei , Gong Tianqing , Huang Qinghua , Zhang Qianqian , Liu Kai , Li Jia , Yu Hai , Cui Yu 
Published: January 2025

Background
Literature regarding the advantages of HFNC in infants for ensuring oxygen supply after non-cardiac surgery is insufficient. The purpose of our study is to compare COT vs. HFNC on postoperative outcomes in infants undergoing non-cardiac surgery. We hypothesize that prophylactic use of HFNC after non-cardiac surgery in infants would reduce the incidence of post-anesthesia hypoxemia and could also be adapted as first-line oxygen therapy after non-cardiac surgery.

Methods
This is a superior, single-blind, randomized controlled study. A total of 394 infants undergoing general anesthesia will be randomly assigned to accept COT or HFNC in a 1:1 ratio. The primary outcome is the rate of desaturation post-extubation. Secondary outcomes include the rate of mild upper airway obstruction, the rate of severe respiratory depression, the rate of transfer to PICU, duration of oxygen therapy, length of PACU stay, the time to reach full enteral feeding, and postoperative adverse events, including nasal injury, agitation, vomiting, and unplanned secondary surgery related to the initial surgery.

Discussion
This is the first randomized controlled trial to explore the advantages of HFNC in infants to ensure oxygen supply after non-cardiac surgery. If favorable evidence is obtained, HFNC could be adopted as first-line oxygen therapy for infants following non-cardiac surgery.

Trial registration
The trial was registered at https://www.chictr.org.cn (Registration number: ChiCTR2400081600, Date: March 6, 2024).
Comparison of early warning scoring systems for predicting stroke occurrence among hospitalized patients: A study using smart clinical data warehouse
Authors: Kim Chulho , Lee Jae Jun , Sohn Jong-Hee , Kim Jong-Ho , Won Dong-Ok , Lee Sang-Hwa 
Published: January 2025

Background
This study aimed to evaluate the predictive ability of two widely used early warning scoring systems, the Modified Early Warning Score (MEWS) and the National Early Warning Score (NEWS), for predicting stroke occurrence in hospitalized patients.

Methods
The study enrolled 5,474 patients admitted to the intensive care unit from the general ward using data from the Smart Clinical Data Warehouse (CDW). MEWS and NEWS were calculated based on vital signs and clinical parameters within four hours of stroke onset. Stroke occurrence was categorized as ischemic or hemorrhagic. Logistic regression and receiver operating characteristic curve analyses were performed to assess the predictive abilities of the scoring systems.

Results
Of the enrolled patients, 33.9% (n = 1853) experienced stroke, comprising 783 cases of ischemic stroke and 1,070 cases of hemorrhagic stroke. Both the MEWS and the NEWS were found to significantly predict overall stroke occurrence with a cutoff value of 4 (MEWS>4; OR [95% CI]: 13.90 [11.51–16.79], p<0.001; NEWS>4; OR [95% CI]: 6.71 [5.75–7.83], p<0.001). Parameters, such as prior malignancy, atrial fibrillation, AVPU response, heart rate, respiratory rate, and oxygen saturation, are also associated with stroke occurrence. The predictive ability of MEWS and NEWS was good for overall stroke occurrence. (AUC of MEWS: 0.92, 95% CI [0.91–0.93], p<0.001; AUC of NEWS: 0.85, 95% CI [0.84–0.86], p<0.001). The predictive ability was considered fair for ischemic stroke but good for hemorrhagic stroke.

Conclusion
MEWS and NEWS demonstrated significant predictive abilities for overall stroke occurrence among hospitalized patients, with MEWS slightly outperforming NEWS.
Effect of music therapy on behavioral and physiological neonatal outcomes: A systematic review and dose-response meta-analysis
Authors: Shahbazi Fatemeh , Fattahi-Darghlou Marzieh , Moslehi Samad , Dabiri-Golchin Minoo , Shahbazi Marjan 
Published: January 2025

Background
Previous studies have documented the effectiveness of music therapy in improving adverse neonatal outcomes in premature infants. However, this review aims to address the question of how long listening to music can enhance these neonatal outcomes.

Methods
To conduct this dose-response meta-analysis, we searched the PubMed, Scopus, Web of Science, and Cochrane Library databases. The inclusion criteria comprised randomized clinical trials that investigated the effects of music therapy on improving adverse neonatal outcomes. Preterm infants were defined as those born between 27 and 37 weeks of gestation, as fetuses are known to respond to auditory stimuli starting at the 27th week of pregnancy. The initial search was performed on January 28, 2024, and there were no restrictions on the time frame for the search. Ultimately, we employed a two-stage random effects model using the “drmeta” package in Stata software to perform this dose-response meta-analysis.

Results
In total, 30 articles (1855 participants) were identified for inclusion in our meta-analysis. According to pooled analysis with each minute increase in music therapy, the means of respiratory rate, pain score, SBP, DBP, behavioral score, and body temperature decrease by 35.3 beats per minutes, 15.3 VAS, 30.7 mmHg, 8.9 mmHg, 2.7, and 0.27°C. On the other hand, with each minute increase in listening to the music, the mean of O2 saturation, heart rate and sleep duration increase 1.7%, 89.2 beats per minutes and 5.081 minutes per day, respectively.

Conclusion
Music therapy improves the neonatal outcomes of O2 saturation, heart rate, respiratory rate, sleep duration, body temperature and systolic and diastolic blood pressures. Therefore, the existence of a dose-response relationship can indicate a causal relationship between music therapy and the improvement of neonatal outcomes.
پەیوەندی فرەحیزبی بە سەقامگیری سیاسی و کۆمەڵایەتی
Authors: Ali Rozhgar M. , Zebari Tahir H. 
Published: January 2025

ئامانج لەم توێژینەوەیە زانینی پەیوەندی فرە حیزبی بە سەقامگیری سیاسی و کۆمەڵایەتییە لە هەرێمی کوردستان، هەربۆیە توێژەران بەمەبەستی گەیشتن بەو ئامانجە سەرەکییە، چەند ئامانجێکی لاوەکییان داناوە کە بریتین لە: ئاشنابوون بە واقعیی سیاسی فرە حیزبی لە هەرێمی کوردستان. کاریگەری ململانێی سیاسی حیزبە سیاسییەکان لە سەر پەیوەندییە کۆمەڵایەتییەکان و گیانی ڕق و تۆڵە سەندنەوە. خستنەڕووی ڕوانگەی فرە حیزی لەبەرجەستە کردنی دیمۆکراسی، بەشداری سیاسی و بونیادنانی حوکمرانیەتییەکی سەقامگیر. هەر بۆیە توێژەران بۆ ئەم توێژینەوەیە پشتیان بە ئاڕاستە چۆنایەتی بەستووە. کۆمەڵگای ئەم توێژینەوەیە کۆی حیزبە سیاسییەکانی هەرێمە کوردستانە. بە ڕێگای نمونەی مەبەستدار (23) کەس لە ئەندامانی سەرکردایەتی حیزبە سیاسییەکانی هەرێمی کوردستان و کەسایەتییە سیاسییەکان هەڵبژێردراون وەکو ئەندامانی نمونەی توێژینەوەکە. ئامرازی بەکار هاتوو لەم توێژینەوەیە بۆ کۆکردنەوەی زانیارییەکان چاوپێکەوتنی نیمچە کراوە بووە.
گرنگترین ئەنجامەکانی توێژینەوەکە بریتیبوون لەوەی: سیستەمی فرە حیزبی وەکو هەر وڵاتێکی ئەم سەردەمە لە کوردستانیش بوونی هەیە. بەڵام ئەو فرە حیزبیە لە هەرێمی کوردستان زیاتر لەوەی سودی هەبێت، زیانی هەبووە و نەتوانراوە وەکو پێویست سود لە پێکەوەبوون و هاوئاهەنگی نێوان یەکتر وەربگرن. هەروەها فرە حیزبی لە کوردستان نەبۆتە هۆی سەقامگیری بەڵکو بە پیچەوانەوە بە هۆی ئەم فرە حیزبییە، ناسەقامگیری زیاتر بووە. فرە حیزبی کاریگەری نەرێنی لە سەر پەیوەندییە کۆمەڵایەتییەکانی نێوان تاکەکان هەبووە، ئەمەش راستەوخۆ کاریگەری لەسەر سەقامگیری کۆمەڵایەتی دادەنێت. کەوایە بەو دەرئەنجامە دەگەین کە لە ئێستادا کە بۆ بەڕێوەبەری بردنی هەر کۆمەڵگایەک سیستەمی فرەیی پێویستە بۆ هەبوونی رای جیاواز و جۆراوجۆر، سەرەرای سودەکانی فرە حیزبی لە هەر وڵاتێک، بەڵام لە کوردستان زیانی زیاترە لە سودەکانی. هەروەها هۆکارێکیش بووە بۆ ناسەقامگیری لە سەرجەم بوارەکانی ژیان.