bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voices of Australian Mature-Age Bachelor of Counselling Students: Telling Stories of Learning and Teaching Transitions
Authors: Abkhezr Peyman , Bath Debra 
Published: April 2023

AbstractThe COVID-19 pandemic imposed transformations on the higher education context of the twenty-first century that adversely impact students’ learning in certain disciplines. On a mission to adopt ethics of care in research and practice, this research focuses on counselling education and its unique characteristics, by signifying counselling students’ voices in such changing contexts. A qualitative exploratory multiple case study design informed by narrative inquiry was used, followed by a voice-centred relational method of analysis. Findings revealed voices, relationships, dominant narratives and power relations that influence counselling students’ learning experiences. Implications for future research and practice for counselling education are highlighted.
Longitudinal Associations of Psychiatric Risk Factors with Non-psychiatric Hospitalization in a Large Cohort of People Living with HIV in New York City
Authors: Breslow Aaron S. , Fazzari Melissa , Franz Peter J. , Hanna David B. , Felson Uriel R. , Cavic Elizabeth , Fisher Marla R. , Bauman Laurie 
Published: April 2023

AbstractHospitalizations among people living with HIV (PLWH) are frequent and costly. This study examined the association between psychiatric, HIV-related, and demographic factors and hospitalization rates among PLWH using data from the Einstein–Rockefeller-City University of New York Center for AIDS Research Clinical Cohort Database. Of the 10,215 PLWH included in the sample, 45% had at least one non-psychiatric hospitalization between 2009 and 2018, with significant risk factors including prior psychiatric outpatient visits, depression, or alcohol-related disorder diagnoses, female sex, older age, CD4 count < 500 cells/uL, and detectable viral load. Additionally, 14% had an HIV-related hospitalization, with significant risk factors including prior psychiatric outpatient visits, alcohol- and substance-related disorder diagnoses, female sex, older age, CD4 count < 500 cells/uL, and detectable viral load. The study emphasizes the need for tailored interventions, including integrated treatment and comprehensive case management, for PLWH with comorbid psychiatric disorders, women, and older adults.
Rapid increase in knowledge about the distribution of introduced predatory Testacella species (Gastropoda: Stylommatophora) in North America by community scientists
Authors: Hausdorf Bernhard 
Published: April 2023

AbstractTestacellidae are a group of carnivorous semislugs with a vestigial ear-shaped shell near the posterior end of their elongate bodies. The single genus Testacella is native to the western Mediterranean and western Europe, but some species have been introduced into temperate countries worldwide. The species are subterranean and feed on earthworms. Due to their predominantly subterranean lifestyle, Testacella species are difficult to observe. Here, I review of the distribution of introduced Testacella species in North America and compare the knowledge based on literature references and museum specimens collected over more than a century with that observed by community scientists on the web platform iNaturalist in less than 10 years. Literature references and museum specimens indicate scattered occurrences of the introduced Testacella haliotidea in the eastern USA and a few more occurrences in the Pacific states of the USA and in British Columbia. Community scientists have nearly replicated a century of knowledge about the distribution of Testacella in North America. Their records even show a more continuous distribution of T. haliotidea in the Pacific states and confirm its presence in Tennessee, but not yet in Pennsylvania. They also provided the first records of T. haliotidea in Georgia and Mexico, and discovered a second introduced Testacella species, Testacella maugei, in California. The most distant occurrences of T. maugei in California are about 100 km apart, indicating that the species was probably introduced several years ago.
miRNA Profiling of Developing Rat Retina in the First Three Postnatal Weeks
Authors: Urbán Péter , Pöstyéni Etelka , Czuni Lilla , Herczeg Róbert , Fekete Csaba , Gábriel Róbert , Kovács-Valasek Andrea 
Published: April 2023

AbstractThe morphogenesis of the mammalian retina depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs play profound roles in various physiological and pathological processes via gene expression regulation. A systematic analysis of the expression profile of small non-coding RNAs in developing Wistar rat retinas (postnatally day 5 (P5), P7, P10, P15 and P21) was executed using IonTorrent PGM next-generation sequencing technique to reveal the crucial players in the early postnatal retinogenesis. Our analysis reveals extensive regulatory potential of microRNAs during retinal development. We found a group of microRNAs that show constant high abundance (miR-19, miR-101; miR-181, miR-183, miR-124 and let-7) during the development process. Others are present only in the early stages (miR-20a, miR-206, miR-133, miR-466, miR-1247, miR-3582), or at later stages (miR-29, miR-96, miR-125, miR-344 or miR-664). Further miRNAs were detected which are differentially expressed in time. Finally, pathway enrichment analysis has revealed 850 predicted target genes that mainly participate in lipid-, amino acid- and glycan metabolisms in the examined time-period (P5–P21). P5–P7 transition revealed the importance of miRNAs in glutamatergic synapse and gap junction pathways. Significantly downregulated miRNAs rno-miR-30c1 and 2, rno-miR-205 and rno-miR-503 were detected to target Prkx (ENSRNOG00000003696), Adcy6 (ENSRNOG00000011587), Gnai3 (ENSRNOG00000019465) and Gja1 (ENSRNOG00000000805) genes. The dataset described here will be a valuable resource for clarifying new regulatory mechanisms for retinal development and will greatly contribute to our understanding of the divergence and function of microRNAs.
Comparison of pre- and in-service primary teachers’ dispositions towards the use of ICT
Authors: Jenßen Lars , Eilerts Katja , Grave-Gierlinger Frederik 
Published: April 2023

AbstractThere is widespread agreement, that today’s students must develop competencies in the efficient use of information and communication technology (ICT) to cope with the demands of the 21st century. To meet this requirement, teachers must integrate ICT into their classroom activities on a regular basis. Studies have shown that the use of ICT in the classroom correlates with the level of professional knowledge and with affective-motivational dispositions (such as emotions and self-efficacy) of teachers. However, the relations between these dispositions and the extent to which these relations differ between pre- and in-service teachers have not yet been investigated. Hence, the present study examines the dispositions of 148 German pre-service and 132 German in-service primary school teachers to use ICT in geometry classes and tests for differences between these groups. To this end, a series of path models have been investigated on the basis of control-value theory in a quantitative study. Results of the invariance testing revealed only minor differences in the relations between the investigated dispositions: For in-service teachers a negative correlation between the assumed value of ICT for teaching geometry and the professional knowledge regarding ICT was found. The same does not hold true for pre-service teachers. Apart from this difference, however, the two groups were very similar. It can therefore be concluded that learning opportunities regarding the use of ICT in geometry classes do not need to differ greatly for the pre-service and in-service teachers.
Studying the characteristics of SQL-related development tasks: An empirical study
Authors: Costa Daniel Alencar da , Grattan Natalie , Stanger Nigel , Licorish Sherlock A. 
Published: April 2023

AbstractA key function of a software system is its ability to facilitate the manipulation of data, which is often implemented using a flavour of the Structured Query Language (SQL). To develop the data operations of software (i.e, creating, retrieving, updating, and deleting data), developers are required to excel in writing and combining both SQL and application code. The problem is that writing SQL code in itself is already challenging (e.g., SQL anti-patterns are commonplace) and combining SQL with application code (i.e., for SQL development tasks) is even more demanding. Meanwhile, we have little empirical understanding regarding the characteristics of SQL development tasks. Do SQL development tasks typically need more code changes? Do they typically have a longer time-to-completion? Answers to such questions would prepare the community for the potential challenges associated with such tasks. Our results obtained from 20 Apache projects reveal that SQL development tasks have a significantly longer time-to-completion than SQL-unrelated tasks and require significantly more code changes. Through our qualitative analyses, we observe that SQL development tasks require more spread out changes, effort in reviews and documentation. Our results also corroborate previous research highlighting the prevalence of SQL anti-patterns. The software engineering community should make provision for the peculiarities of SQL coding, in the delivery of safe and secure interactive software.
Exploring the potential of agricultural system change as an integrated adaptation strategy for water and food security in the Indus basin
Authors: Smolenaars Wouter Julius , Jamil Muhammad Khalid , Dhaubanjar Sanita , Lutz Arthur F. , Immerzeel Walter , Ludwig Fulco , Biemans Hester 
Published: April 2023

AbstractWater security and food security in the Indus basin are highly interlinked and subject to severe stresses. Irrigation water demands presently already exceed what the basin can sustainably provide, but per-capita food availability remains limited. Rapid population growth and climate change are projected to further intensify pressure on the interdependencies between water and food security. The agricultural system of the Indus basin must therefore change and adapt to be able to achieve the associated Sustainable Development Goals (SDGs). The development of robust policies to guide such changes requires a thorough understanding of the synergies and trade-offs that different strategies for agricultural development may have for water and food security. In this study, we defined three contrasting trajectories for agricultural system change based on a review of scientific literature on regional agricultural developments and a stakeholder consultation workshop. We assessed the consequences of these trajectories for water and food security with a spatially explicit modeling framework for two scenarios of climatic and socio-economic change over the period 1980–2080. Our results demonstrate that agricultural system changes can ensure per capita food production in the basin remains sufficient under population growth. However, such changes require additional irrigation water resources and may strongly aggravate water stress. Conversely, a shift to sustainable water management can reduce water stress but has the consequence that basin-level food self-sufficiency may not be feasible in future. This suggests that biophysical limits likely exist that prevent agricultural system changes to ensure both sufficient food production and improve water security in the Indus basin under strong population growth. Our study concludes that agricultural system changes are an important adaptation mechanism toward achieving water and food SDGs, but must be developed alongside other strategies that can mitigate its adverse trade-offs.
Assessment of male reproductive traits in endangered leuciscids from the Iberian Peninsula: first attempts to store gametes both at short- and long-term
Authors: Hernández-Rodríguez Ana , Sousa-Santos Carla , Gil Fátima , Cabrita Elsa , Guerreiro Pedro M. , Gallego Victor 
Published: April 2023

AbstractDuring the spring of 2022, several endangered leuciscid species (Anaecypris hispanica, Squalius aradensis, Anachondrostoma Occidentale, and Iberochondrostoma lusitanicum) were sampled both at the Vasco da Gama aquarium facilities and in some rivers of the Algarve region, Portugal. Sperm samples were extracted by gentle abdominal pressure and sperm motion parameters were assessed for the first time in four species, using a computerized analysis system. The results obtained showed that spermatozoa kinetic patterns were similar for all 4 species, with high motility and velocity values after the sperm activation time and with a marked decrease after 20. On the other hand, sperm longevity was highly variable between species, with short longevities (around 40 s) for A. hispanica and S. aradensis, and longer longevities (100–120 s) for A. occidentale and I. lusitanicum, which could indicate a latitudinal pattern in terms of sperm longevity. At the same time, morphometric analysis was carried out for the four target species, revealing that spermatozoa showed similar sizes and shapes to other external fertilizers belonging to Leuscididae, with small spherical heads, uniflagellate, and without acrosomes. In addition, a short-term gamete storage trail was performed by diluting sperm in 1:9 (sperm:extender) and storing them at 4ºC. Although the results obtained were uneven among the species studied, the dilution and extender used generated motilities above 40% up to day 4 of storage in S. aradensis and I. lusitanicum, and up to days 1–2 in A. hispanica and A. occidentale, respectively. Finally, gamete cryopreservation trials were also carried out on these threatened species. Although cryopreserved samples showed significantly lower motility than fresh samples, some protocols generate acceptable percentages of viability, DNA integrity, and sperm motility in some species such as I. lusitanicum and A. occidentale. The data revealed that the protocol based on 10% DMSO plus 7.5% egg yolk generated the best results.This study is the first to assess the reproductive traits of wild and captive populations of endangered leuciscids endemic from the Iberian Peninsula, describing the spermatozoa kinetics and developing protocols for managing male gametes both in short- and long-term storage. Outcomes will provide new and useful tools to complement the management and conservation of ex situ breeding programs that are being developed for these four endangered species.
Fate and cost effectiveness of soil carbon sequestered using supplementary nutrients applied to crop residues under field conditions
Authors: Kirkegaard John A. , Richardson Alan E. , Kirkby Clive A. 
Published: April 2023

AbstractChanges in carbon (C) and nitrogen (N) associated with fine fraction (FF) soil organic matter (SOM) were determined to a depth of 1.80 m at a field site that was managed with supplementary nutrients (2007–2012) to sequester soil C from crop residues. Soil C and N stocks were monitored for a further 3 years (to 2015) with supplementary nutrients maintained, and then for 5 years after they were ceased (2015–2020). The increase in FF-C established in the first phase of nutrient addition (9.6 Mg C ha−1) was maintained during the ongoing 3 year period of nutrient addition (9.8 Mg C ha−1) but declined to 3.0 Mg C ha−1 during the subsequent 5 years when nutrient addition ceased. The decline in FF-C stocks was attributed to both less formation of FF-C without the supplementary nutrients applied, and to nutrient mining as insufficient N was being applied to both treatments to fully satisfy the N removed in crops. The addition of supplementary nutrients to the residue influenced crop yield in some years, and seed protein in most years, but the responses were crop and season dependant and there was no overall difference in the amount of C in crop biomass returned to the soil. An economic analysis using long-term fertiliser and grain prices suggested that the strategy to sequester more C in FF-SOM through nutrient addition to residue was essentially cost neutral. Better tailoring of nutrient inputs to achieve the required stoichiometric ratios in SOM, and an assumed payment for the sequestered C (AU$40 Mg−1 CO2 equivalent) provided a reliable economic benefit during the period of nutrient addition. However the economic benefit was lost when nutrient addition ceased, and would reduce if fertiliser prices increased or the C price declined. Our results confirm that addition of supplementary nutrients to C-rich crop residues is an effective means to sequester soil C that can persist for several years even after nutrient addition ceases. However, ongoing nutrient inputs in excess of crop removal are required to ensure long-term sequestration of the C from crop residue.
Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC–MS: relationship between detection and stability
Authors: La Rocca Paolo , Lavota Ivana , Piccoli Marco , Cirillo Federica , Ghiroldi Andrea , Ciconte Giuseppe , Pappone Carlo , Allevi Pietro , Rota Paola , Anastasia Luigi 
Published: April 2023

AbstractA subclass of the sialic acid family consists of intramolecular lactones that may function as key indicators of physiological and pathological states. However, the existence of these compounds in free form is highly improbable, since they are unlikely to exist in an aqueous solution due to their lability. Current analytical method used to detect them in biological fluids has not recognized their reactivity in solution and is prone to misidentification. However, recent advances in synthetic methods for 1,7-lactones have allowed the preparation of these sialic acid derivatives as authentic reference standards. We report here the development of a new HPLC–MS method for the simultaneous detection of the 1,7-lactone of N-acetylneuraminic acid, its γ-lactone derivative, and N-acetylneuraminic acid that overcomes the limitations of the previous analytical procedure for their identification.
Acute advanced aortic stenosis
Authors: Avvedimento Marisa , Angellotti Domenico , Ilardi Federica , Leone Attilio , Scalamogna Maria , Castiello Domenico Simone , Manzo Rachele , Mariani Andrea , Immobile Molaro Maddalena , Simonetti Fiorenzo , Spaccarotella Carmen Anna Maria , Piccolo Raffaele , Esposito Giovanni , Franzone Anna 
Published: April 2023

AbstractAcute decompensation often represents the onset of symptoms associated with severe degenerative aortic stenosis (AS) and usually complicates the clinical course of the disease with a dismal impact on survival and quality of life. Several factors may derange the faint balance between left ventricular preload and afterload and precipitate the occurrence of symptoms and signs of acute heart failure (HF). A standardized approach for the management of this condition is currently lacking. Medical therapy finds very limited application in this setting, as drugs usually indicated for the control of acute HF might worsen hemodynamics in the presence of AS. Urgent aortic valve replacement is usually performed by transcatheter than surgical approach whereas, over the last decades, percutaneous balloon valvuloplasty gained renewed space as bridge to definitive therapy. This review focuses on the pathophysiological aspects of acute advanced AS and summarizes current evidence on its management.
Do budget constraints limit access to health care? Evidence from PCI treatments in Hungary
Authors: Kiss András , Kiss Norbert , Váradi Balázs 
Published: April 2023

AbstractUnder Hungary’s single payer health care system, hospitals face an annual budget cap on most of their diagnoses-related group based reimbursements. In July 2012, percutaneous coronary intervention (PCI) treatments of acute myocardial infarction were exempted from that hospital level budget cap. We use countrywide individual-level patient data from 2009 to 2015 to map the effect of such a quasi-experimental change in monetary incentives on health provider decisions and health outcomes. We find that direct admissions into PCI-capable hospitals increase, especially in central Hungary, where there are several hospitals which can compete for patients. The proportion of PCI treatments at PCI-capable hospitals, however, does not increase, and neither does the number of patient transfers from non-PCI hospitals to PCI-capable ones. We conclude that only patient pathways, plausibly influenced by hospital management, were affected by the shift in incentives, while physicians’ treatment decisions were not. While average length of stay decreased, we do not find any effect on 30-day readmissions or in-hospital mortality.
Operational characteristics of full random effects modelling (‘frem’) compared to stepwise covariate modelling (‘scm’)
Authors: Amann Lisa F. , Wicha Sebastian G. 
Published: April 2023

AbstractAn adequate covariate selection is a key step in population pharmacokinetic modelling. In this study, the automated stepwise covariate modelling technique (‘scm’) was compared to full random effects modelling (‘frem’). We evaluated the power to identify a ‘true’ covariate (covariate with highest correlation to the pharmacokinetic parameter), precision, and accuracy of the parameter-covariate estimates. Furthermore, the predictive performance of the final models was assessed. The scenarios varied in covariate effect sizes, number of individuals (n = 20–500) and covariate correlations (0–90% cov-corr). The PsN ‘frem’ routine provides a 90% confidence intervals around the covariate effects. This was used to evaluate its operational characteristics for a statistical backward elimination procedure, defined as ‘fremposthoc’ and to facilitate the comparison to ‘scm’. ‘Fremposthoc’ had a higher power to detect the true covariate with lower bias in small n studies compared to ‘scm’, applied with commonly used settings (forward p < 0.05, backward p < 0.01). This finding was vice versa in a statistically similar setting. For ‘fremposthoc’, power, precision and accuracy of the covariate coefficient increased with higher number of individuals and covariate effect magnitudes. Without a backward elimination step ‘frem’ models provided unbiased coefficients with highly imprecise coefficients in small n datasets. Yet, precision was superior to final ‘scm’ model precision obtained using common settings. We conclude that ‘fremposthoc’ is also a suitable method to guide covariate selection, although intended to serve as a full model approach. However, a deliberated selection of automated methods is essential for the modeller and using those methods in small datasets needs to be taken with caution.
Finite-Temperature Avalanches in 2D Disordered Ising Models
Authors: Ettori Federico , Perani Filippo , Turzi Stefano , Biscari Paolo 
Published: April 2023

AbstractWe study the qualitative and quantitative properties of the Barkhausen noise emerging at finite temperatures in random Ising models. The random-bond Ising Model is studied with a Wolff cluster Monte-Carlo algorithm to monitor the avalanches generated by an external driving magnetic field. Satisfactory power-law distributions are found which expand over five decades, with a temperature-dependent critical exponent which matches the existing experimental measurements. We also focus on a Ising system in which a finite fraction of defects is quenched. Also the presence of defects proves able to induce a critical response to a slowly oscillating magnetic field, though in this case the critical exponent associated with the distributions obtained with different defect fractions and temperatures seems to belong to the same universality class, with a critical exponent close to 1.