bluuebunny/crossref_metadata_2025_split huggingface dataset:
Customer benefits and value creation in streaming services marketing: a managerial cognitive capability approach
Authors: Chen Yi‐Min , Liu Hsin‐Hsien , Chiu Yu‐Chun 
Published: September 2023

AbstractCustomer value analysis and management is a key theoretical and empirical issue in marketing management and strategic management. However, little is known about the influence of customer benefit on customer value from the microfoundations of the dynamic capabilities perspective. Currently, a boom in online video and music streaming services is changing the entertainment industry structure. Thus, marketing managers in the fast‐growing streaming services industry should have dynamic managerial capabilities to anticipate other service elements that customers consider valuable. Based on managerial cognitive dynamic capabilities, this research explored the influences of customer‐perceived functional benefit, experiential benefit, financial benefit, and psychosocial benefit on perceived instrumental and terminal values. General linear model (GLM) and fuzzy‐set qualitative comparative analysis (fsQCA) were conducted to gain a more nuanced understanding of how different customers’ perceived benefits have different impacts on perceived value. The findings illuminate complex benefit configurations that drive perceived instrumental and terminal values and contribute to the development of value creation and its drivers. The proposed framework can help managers develop managerial cognitive dynamic capabilities by increasing their understanding of the impact of different perceived benefits on value creation for different types of customers.
Characterization of concomitant gradient fields and their effects on image distortions using a low‐field point‐of‐care Halbach‐based MRI system
Authors: de Vos Bart , Remis Rob F. , Webb Andrew G. 
Published: September 2023

AbstractPurposeConcomitant gradient fields have been extensively studied at clinical field strengths. However, their effects have not yet been modeled for low‐field point‐of‐care (POC) systems. The purpose of this work is to characterize the effects associated with concomitant fields for POC Halbach‐array‐based systems.MethodsThe concomitant fields associated with a cylindrical gradient coils designed for a transverse and a signal model including the tilting effect of the effective magnetic field are derived. The formalism is used to simulate and predict concomitant field related distortions. A 46‐mT Halbach‐array‐based system with a maximum gradient strength of 15 mT/m is used to verify the model using two‐dimensional spin‐echo sequences.ResultsThe simulations and experimental results are in good agreement with the derived equations. The fundamental characteristics of the concomitant field equations are different to conventional MRI systems: Image distortions occur primarily in the transverse directions and a cross‐term only exists when applying transverse gradient pulses simultaneously.ConclusionThe level of image warping in the frequency encoding direction is insignificant for the POC systems discussed here. However, when trying to achieve short echo‐times by using strong phase encoding and readout‐dephasing gradients, the combination can result in image warping and blurring which should be accounted for in image interpretation.
Simultaneous perfusion, diffusion, T2*, and T1 mapping with MR fingerprinting
Authors: Fan Hongli , Bunker Lisa , Wang Zihan , Durfee Alexandra Zezinka , Lin Doris , Yedavalli Vivek , Ge Yulin , Zhou Xiaohong Joe , Hillis Argye E. , Lu Hanzhang 
Published: September 2023

AbstractPurposeQuantitative mapping of brain perfusion, diffusion, T2*, and T1 has important applications in cerebrovascular diseases. At present, these sequences are performed separately. This study aims to develop a novel MRI technique to simultaneously estimate these parameters.MethodsThis sequence to measure perfusion, diffusion, T2*, and T1 mapping with magnetic resonance fingerprinting (MRF) was based on a previously reported MRF‐arterial spin labeling (ASL) sequence, but the acquisition module was modified to include different TEs and presence/absence of bipolar diffusion‐weighting gradients. We compared parameters derived from the proposed method to those derived from reference methods (i.e., separate sequences of MRF‐ASL, conventional spin‐echo DWI, and T2* mapping). Test–retest repeatability and initial clinical application in two patients with stroke were evaluated.ResultsThe scan time of our proposed method was 24% shorter than the sum of the reference methods. Parametric maps obtained from the proposed method revealed excellent image quality. Their quantitative values were strongly correlated with those from reference methods and were generally in agreement with values reported in the literature. Repeatability assessment revealed that ADC, T2*, T1, and B1+ estimation was highly reliable, with voxelwise coefficient of variation (CoV) <5%. The CoV for arterial transit time and cerebral blood flow was 16% ± 3% and 25% ± 9%, respectively. The results from the two patients with stroke demonstrated that parametric maps derived from the proposed method can detect both ischemic and hemorrhagic stroke.ConclusionThe proposed method is a promising technique for multi‐parametric mapping and has potential use in patients with stroke.
Farmers' green technology adoption: Implications from government subsidies and information sharing
Authors: Hong Xianpei , Chen Ying‐Ju , Gong Yeming , Wang Hua 
Published: September 2023

AbstractWhile the previous literature on green technology adoption has not fully considered information sharing, we consider the impact of demand information sharing on the adoption of green technologies by risk‐averse farmers in a vertical agricultural supply chain. We find that government subsidies and information sharing do not always promote farmers' adoption of green technologies. The accuracy of the information plays a vital role in promoting farmers' adoption of green technologies; however, the increased green technology adoption induced by more accurate information may be detrimental to farmer welfare in the presence of production diseconomies. Information sharing can reduce the amount of government subsidies for promoting green technology adoption, thereby suggesting the substitutable role of information and monetary instruments. Nonetheless, information‐sharing may lead to lower water savings and thus should be adopted with caution. Risk aversion has a nontrivial impact on agricultural technology adoption: farmers are more likely to adopt traditional agricultural technologies when their risk aversion is either very low or very high. Finally, we validate our decision model with U.S. Department of Agriculture cotton production data and propose management insights to help farmers make appropriate adoption decisions under information asymmetry and risk‐averse attitudes.
GPR modelling and inversion to quantify the debris content within ice
Authors: Santin Ilaria , Roncoroni Giacomo , Forte Emanuele , Gutgesell Pietro , Pipan Michele 
Published: September 2023

AbstractScattering is often detected when ground‐penetrating radar (GPR) surveys are performed on glaciers at different latitudes and in various environments. This event is often seen as an undesirable feature on data, but it can be exploited to quantify the debris content in mountain glaciers through a dedicated scattering inversion approach. At first, we considered the possible variables affecting the scattering mechanisms, namely the dielectric properties of the scatterers, their size, shape and quantity, as well as the wavelength of the electromagnetic (EM) incident field to define the initial conditions for the inversion. Each parameter was independently evaluated with forward modelling tests to quantify its effect in the scattering mechanism. After extensive tests, we found that the dimension and the amount of scatterers are the crucial parameters. We further performed modelling randomizing the scatterer distribution and dimension, critically evaluating the stability of the approach and the complexity of the models. After the tests on synthetic data, the inversion procedure was applied to field datasets, acquired on the Eastern Gran Zebrù glacier (Central Italian Alps). The results show that even a low percentage of debris can produce high scattering. The proposed methodology is quite robust and able to provide quantitative estimates of the debris content within mountain glaciers in different conditions.
Public sector reforms in developing countries: A preliminary review
Authors: Knox Colin , Sharipova Dina 
Published: September 2023

AbstractDeveloping countries have adopted or adapted public sector reform interventions based largely on the model of new public management (NPM). Since this model has now been rejected as a global ‘one‐size‐fits‐all’ framework, what does post‐new public management hold for developing countries? This paper offers a preliminary review of the literature on public sector reforms in developing countries. It charts scholarship which examined the evolution (including different types of policy interventions), the failure of NPM, and contemporary approaches to reform. The post‐new public management era is ill‐defined, eclectic, and characterised as hybrid and layered where new reforms are superimposed on pre‐existing interventions to deliver ‘good enough’ governance in developing countries.
Prenatal diagnosis and treatment for fetal angiotensin converting enzyme deficiency
Authors: Tan Hang‐Jing , Jian Wen‐Yan , Lv Chao , Guo De‐Wei , Liao Zheng‐Chang , Xu Hui , Xiao Yao , Schiller Martin , Zhuo Jia‐Long , Yue Shao‐Jie , Yao Ruo‐Jin , Deng Hong‐Wen , Xiao Hong‐Mei 
Published: September 2023

AbstractObjectiveTo elucidate an etiology in a case with persistent oligohydramnios by prenatal diagnosis and actively treat the case to achieve good prognosis.MethodsWe performed whole exome sequencing (WES) of DNA from the fetus and parents. Serial amnioinfusions were conducted until birth. Pressors were required to maintain normal blood pressure. The infant angiotensin‐converting enzyme (ACE) activity, angiotensin II (Ang II, a downstream product of ACE), and compensatory enzymes (CEs) activities were measured. Compensatory enzyme activities in plasma from age‐matched healthy controls were also detected.ResultsWe identified a fetus with a severe ACE mutation prenatally. The infant was born prematurely without pulmonary dysplasia. Hypotension and anuria resolved spontaneously. He had almost no ACE activity, but his Ang II level and CE activity exceeded the upper limit of the normal range and the upper limit of the 95% confidence interval of controls, respectively. His renal function also largely recovered.ConclusionFetuses with ACE mutations can be diagnosed prenatally through WES. Serial amnioinfusion permits the continuation of pregnancy in fetal ACE deficiency. Compensatory enzymes for defective ACE appeared postnatally. Renal function may be spared by preterm delivery; furthermore, for postnatal vasopressor therapy to begin, improving renal perfusion pressure before nephrogenesis has been completed.
The weighted cumulative exposure method and its application to pharmacoepidemiology: A narrative review
Authors: Kelly Thu‐Lan , Salter Amy , Pratt Nicole L. 
Published: September 2023

AbstractPurposeThe weighted cumulative exposure (WCE) method has been used in a number of fields including pharmacoepidemiology where it can account for intensity, duration and timing of exposures on the risk of an outcome. The method uses a data driven approach with flexible cubic B‐splines to assign weights to past doses and select an aetiologically appropriate time window. Predictions of risk are possible for common exposure patterns encountered in real‐world studies. The purpose of this study was to describe applications of the WCE method to pharmacoepidemiology and assess the strengths and limitations of the method.MethodA literature search was undertaken to find studies applying the WCE method to the study of medicines. Articles published in PubMed using the search term ‘weighted cumulative exposure’ and articles citing Sylvestre et al. (2009) in Google Scholar or Scopus up to March 2023 were subsequently reviewed. Articles were selected based on title and review of abstracts.ResultsSeventeen clinical applications using the data‐driven WCE method with flexible cubic splines were identified in the review. These included 3 case–control studies and 14 cohort studies, of which 12 were analysed with Cox proportional hazards models and 2 with logistic regression. Thirteen studies used time windows of 1 year or longer. Of 11 studies which compared conventional models with the WCE method, 10 (91%) studies found a better fit with WCE models while one had an equivalent fit. The freely available ‘WCE’ software package has facilitated the applications of the WCE method with flexible cubic splines.ConclusionsThe WCE method allows additional insights into the effect of cumulative exposure on outcomes, including the timing and intensity (dose) of the exposure on the risk. The flexibility of the method is particularly well suited to studies with long‐term exposures that vary over time or where the current risk of an event is affected by how far the exposure is in the past, which is difficult to model with conventional definitions of exposure. Interpretation of the results can be more complex than for conventional models and would be facilitated by a standardised reporting framework.
Safety of removal of ProSeal laryngeal mask airway in children in the supine versus lateral position in a deep plane of anesthesia: A randomized controlled trial
Authors: Dhiman Shweta , Bhalotra Anju R. , Sharma Kavita R. 
Published: September 2023

ABSTRACTImportanceWhen a ProSeal laryngeal mask airway (PLMA) is removed with the child in a deep plane of anesthesia, the upper airway muscle tone and protective upper airway reflexes may be obtunded.ObjectiveTo determine whether the supine or lateral position is safer for the removal of a PLMA in deeply anesthetized children by comparing the incidence of upper airway complications.MethodsThis randomized single‐blind comparative trial was conducted at a tertiary care hospital between January 2020 and September 2020. Forty children of the American Society of Anesthesiologists class I/II of ages 1–12 years age undergoing surgery under general anesthesia with PLMA used as the definitive airway device were recruited. Patients were randomly allocated to lateral group or supine group for PLMA removal in a deep plane of anesthesia in the lateral or supine position. The primary outcome was the number of patients experiencing one or more upper airway complications and the secondary outcomes were incidence of individual respiratory adverse effects and of severe airway complications.ResultsThe incidence of airway complications was 30% in the supine group and 20% in the lateral group (P = 0.6641). Incidence of laryngospasm, immediate stridor, and excessive secretions were similar. Early stridor and oxygen desaturation were higher in the supine group (P = 0.0374, P = 0.0183 respectively).InterpretationThe overall incidence of upper airway complications was similar with the removal of a PLMA in the supine or lateral position in deeply anesthetized children. The incidence of oxygen desaturation and stridor were higher with PLMA removal in the supine as compared to the lateral position.
Multiple urinary peptides display distinct sex‐specific distribution
Authors: Mina Ioanna K. , Mavrogeorgis Emmanouil , Siwy Justyna , Stojanov Riste , Mischak Harald , Latosinska Agnieszka , Jankowski Vera 
Published: September 2023

AbstractPrevious studies have established the association of sex with gene and protein expression. This study investigated the association of sex with the abundance of endogenous urinary peptides, using capillary electrophoresis‐coupled to mass spectrometry (CE‐MS) datasets from 2008 healthy individuals and patients with type II diabetes, divided in one discovery and two validation cohorts. Statistical analysis using the Mann–Whitney test, adjusted for multiple testing, revealed 143 sex‐associated peptides in the discovery cohort. Of these, 90 peptides were associated with sex in at least one of the validation cohorts and showed agreement in their regulation trends across all cohorts. The 90 sex‐associated peptides were fragments of 29 parental proteins. Comparison with previously published transcriptomics data demonstrated that the genes encoding 16 of these parental proteins had sex‐biased expression. The 143 sex‐associated peptides were combined into a support vector machine‐based classifier that could discriminate males from females in two independent sets of healthy individuals and patients with type II diabetes, with an AUC of 89% and 81%, respectively. Collectively, the urinary peptidome contains multiple sex‐associated differences, which may enable a better understanding of sex‐biased molecular mechanisms and the development of more accurate diagnostic, prognostic, or predictive classifiers for each individual sex.
Lavaka (erosional gullies) provide productive patch environments for flora and farming in Madagascar's grassy highlands
Authors: Cox Rónadh , Carrère Alizé , Rakotondrazafy Amos F. M. , Voarintsoa Ny Riavo 
Published: September 2023

Societal Impact StatementLavaka, large gullies in Madagascar, can cause problems for farmers and for infrastructure, but these features also have beneficial aspects that have generally been overlooked. They provide plant refugia, and commonly host species that would otherwise not thrive on the grassy uplands. Farmers sometimes make use of lavaka to plant crops that require more protection or soil moisture. Colonial narratives blame lavaka erosion on poor land management but ignore their pre‐human‐settlement existence on the landscape and the ecological functions they serve. The knowledge and wisdom of Malagasy farmers are key to better understanding the complex roles that lavaka plays in the landscape.SummaryThis paper combines a review of lavaka—erosional gullies in Madagascar's grass‐covered highlands—with new observations of their importance as ecological patch environments for a wide range of plants not seen elsewhere within the grassy biome. Lavaka play a role as a natural refugia for flora that would otherwise not thrive on the exposed and infertile hillslopes, and local farmers exploit their topography and sediment deposits to grow a variety of crops. We provide a classification scheme for lavaka based on the extent to which they have been colonised by vegetation. Our analysis is based on observations made over many field seasons in the highlands as well as interviews with Malagasy farmers living with lavaka on their land. We emphasise the importance of local knowledge and environmental wisdom in the analysis of landscape evolution, and we conclude that lavaka, while certainly an erosional problem in many places, can nonetheless provide valuable ecosystem services and agricultural opportunities that should not be overlooked.
A Markov model of fibrosis development in nonalcoholic fatty liver disease predicts fibrosis progression in clinical cohorts
Authors: Knöchel Jane , Bergenholm Linnéa , Ibrahim Eman , Kechagias Stergios , Hansson Sara , Liljeblad Mathias , Nasr Patrik , Carlsson Björn , Ekstedt Mattias , Ueckert Sebastian 
Published: September 2023

AbstractDisease progression in nonalcoholic steatohepatitis (NASH) is highly heterogenous and remains poorly understood. Fibrosis stage is currently the best predictor for development of end‐stage liver disease and mortality. Better understanding and quantifying the impact of factors affecting NASH and fibrosis is essential to inform a clinical study design. We developed a population Markov model to describe the transition probability between fibrosis stages and mortality using a unique clinical nonalcoholic fatty liver disease cohort with serial biopsies over 3 decades. We evaluated covariate effects on all model parameters and performed clinical trial simulations to predict the fibrosis progression rate for external clinical cohorts. All parameters were estimated with good precision. Age and diagnosis of type 2 diabetes (T2D) were found to be significant predictors in the model. Increase in hepatic steatosis between visits was the most important predictor for progression of fibrosis. Fibrosis progression rate (FPR) was twofold higher for fibrosis stages 0 and 1 (F0‐1) compared to fibrosis stage 2 and 3 (F2‐3). A twofold increase in FPR was observed for T2D. A two‐point steatosis worsening increased the FPR 11‐fold. Predicted fibrosis progression was in good agreement with data from external clinical cohorts. Our fibrosis progression model shows that patient selection, particularly initial fibrosis stage distribution, can significantly impact fibrosis progression and as such the window for assessing drug efficacy in clinical trials. Our work highlights the increase in hepatic steatosis as the most important factor in increasing FPR, emphasizing the importance of well‐defined lifestyle advise for reducing variability in NASH progression during clinical trials.
Growth Anisotropy and Morphology Evolution of Line Defects in Monolayer MoS2: Atomic‐Level Observation, Large‐Scale Statistics, and Mechanism Understanding
Authors: Li Shouheng , Lin Jinguo , Chen Yun , Luo Zheng , Cheng Haifeng , Liu Feng , Zhang Jin , Wang Shanshan 
Published: September 2023

AbstractUnderstanding the growth behavior and morphology evolution of defects in 2D transition metal dichalcogenides is significant for the performance tuning of nanoelectronic devices. Here, the low‐voltage aberration‐corrected transmission electron microscopy with an in situ heating holder and a fast frame rate camera to investigate the sulfur vacancy lines in monolayer MoS2 is applied. Vacancy concentration‐dependent growth anisotropy is discovered, displaying first lengthening and then broadening of line defects as the vacancy densifies. With the temperature increase from 20 °C to 800 °C, the defect morphology evolves from a dense triangular network to an ultralong linear structure due to the temperature‐sensitive vacancy migration process. Atomistic dynamics of line defect reconstruction on the millisecond time scale are also captured. Density functional theory calculations, Monte Carlo simulation, and configurational force analysis are implemented to understand the growth and reconstruction mechanisms at relevant time and length scales. Throughout the work, high‐resolution imaging is closely combined with quantitative analysis of images involving thousands of atoms so that the atomic‐level structure and the large‐area statistical rules are obtained simultaneously. The work provides new ideas for balancing the accuracy and universality of discoveries in the TEM study and will be helpful to the controlled sculpture of nanomaterials.