bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Fraud Pentagon on Fraudulent Financial Reporting
Authors: Fahira Hanna Nihayah , Purnomo Margo , Rasmini Mas 
Published: July 2023

The purpose of this research is to demonstrate and investigate the influence of the fraud pentagon on fraudulent financial reporting. A quantitative technique was applied in the investigation. This study makes use of secondary data and a purposive sampling technique. The sample for this study consisted of 31 Property and Real Estate Sub-Sector Service Companies that were listed on the IDX from 2017 to 2019. Regression analysis of panel data was employed as the statistical strategy in this investigation. The findings show that the pressure and opportunity variables have a positive and significant impact on fraudulent financial reporting. Meanwhile, rasionalization, competence, and arrogance all have a negative and minor impact on fraudulent financial reporting. This study, on the other hand, shows that pressure, opportunity, rationalization, competence, and arrogance all have an impact on dishonest financial reportingKeywords: Pressure,Opportunity,Rasionalization,Competence,Arrogance
CORRUPTION, EASE OF DOING BUSINESS, FOREIGN DIRECT INVESTMENT, AND COMPETITIVENESS IN ASEAN COUNTRIES
Authors: Azwardi Azwardi , Wijaya Wahyu Aji 
Published: July 2023

This study aims to analyze perceptions of corruption, ease of doing business, foreign investment on national competitiveness in ASEAN countries. This study uses panel data analysis with CEM, FEM, and REM approaches by using research samples from 10 countries that are members of the ASEAN organization. The results showed that Corruption Perception (CPI), ease of doing business, and Foreign Direct Investment had a significant and positive effect on National Competitiveness in ASEAN Countries.
ПІДХОДИ ДО ВИЗНАЧЕННЯ ВПЛИВУ ПСИХОГЕННИХ ВТРАТ НА ЕФЕКТИВНІСТЬ ФУНКЦІОНУВАННЯ СИСТЕМИ ПРОТИПОВІТРЯНОЇ ОБОРОНИ ВІЙСЬКОВИХ ФОРМУВАНЬ ТАКТИЧНОГО РІВНЯ В НАСТУПАЛЬНОМУ БОЮ
Authors: Гогонянц Спартак Юрійович , Горбачов Костянтин Миколайович , Смірнов Іван Іванович , Базіло Сергій Михайлович 
Published: July 2023

Досвід проведення Операції об'єднаних сил та антитерористичної операції на сході України вказує на необхідність урахування впливу реальної бойової обстановки на виконання військовими формуваннями тактичного рівня бойових завдань. Одним з основних чинників, що може впливати на результати ведення наступального бою, буде готовність особового складу, зокрема психологічна. Особливо це стосується підрозділів протиповітряної оборони, що мають на озброєнні складну (комплексну) колективну (групову) зброю та одними з перших вступають у протиборство з противником.
Так, вже в ході підготовки до наступального бою, на особовий склад чергових сил, що на цьому етапі є основою побудови системи протиповітряної оборони військових формувань тактичного рівня, починає негативно впливати низка психотравмуючих факторів. Що, в подальшому, може призвести до виникнення психогенних втрат, кількість яких на інших етапах наступального бою може тільки зростати. А зважаючи на вказану вище особливість застосування озброєння, будь-який негативний вплив навіть на одного члена екіпажу бойової машини (установки), може призводити до зниження можливостей бойової машини (установки),цільового каналу в цілому.
Аналіз досліджень, присвячених питанням підготовки і ведення протиповітряної оборони військовими формуваннями тактичного рівня, вказує на те, що існуючий науково-методичний апарат оцінювання ефективності функціонування системи протиповітряної оборони в загальновійськовому бою, в цілому, дозволяє здійснювати основні тактичні розрахунки, але не є досконалим. А саме, потребує забезпечення врахування негативного впливу комплексу психотравмуючих факторів бойової обстановки, а також викликаних ними психогенних втрат серед особового складу підрозділів протиповітряної оборони, особливо у наступальному бою..
У статті викладено результати пошуку можливих підходів до урахування санітарних і безповоротних психогенних втрат особового складу, що прогнозуються, в ході планування протиповітряної оборони військових формувань тактичного рівня в наступальному бою.
Запропоновано варіант її впровадження в загальну методику оцінювання ефективності функціонування системи протиповітряної оборони військових формувань тактичного рівня, яка використовується у військах протиповітряної оборони Сухопутних військ Збройних Сил України, дозволить, на відміну від існуючої, отримувати більш об'єктивні та адекватні до умов наступального бою результати.
ОБҐРУНТУВАННЯ ЗАСТОСУВАННЯ ДИФУЗІЙНО-НЕМОНОТОННОГО РОЗПОДІЛУ У ЯКОСТІ МОДЕЛІ ВІДМОВ АВІАЦІЙНИХ ЗАСОБІВ УРАЖЕННЯ
Authors: Диптан Валентин Петрович , Яблонський Петро Михайлович , Дуленко Дмитро Іванович , Поліщук Василь Володимирович , П’явчук Олександр Олександрович 
Published: July 2023

У доповіді розглянуті загальні характеристики найбільш вживаних законів розподілу неперервних випадкових величин, які використовуються в теорії надійності.
При цьому в якості вихідного параметру використовується залежність розбіжності в оцінці показників надійності авіаційних засобів ураження від вибору відповідної теоретичної моделі розподілу напрацювання до відмови, яка в залежності від прийнятої теоретичної моделі може становити кілька порядків. В результаті цей вибір визначає точність розрахункових кількісних показників надійності розроблюваних методик підвищення ефективності технічного обслуговування авіаційних засобів ураження.
ПОГЛЯДИ ЩОДО НАПРЯМКІВ РОЗВИТКУ ПОВІТРЯНИХ СИЛ ЗБРОЙНИХ СИЛ УКРАЇНИ З УРАХУВАННЯМ ДОСВІДУ РОСІЙСЬКО-УКРАЇНСЬКОЇ ВІЙНИ
Authors: Олещук Микола , Коршець Олена , Горбенко Володимир 
Published: July 2023

На підставі досвіду застосування Повітряних Сил Збройних Сил України під час триваючої російсько-української війни, визначені можливі напрямки розвитку Повітряних Сил Збройних Сил України з огляду на ймовірні сценарії загроз в повітряному просторі.
В статті проаналізовано існуючий склад, стан та завдання Повітряних Сил Збройних Сил України в умовах протидії повномасштабній агресії російської федерації. Розглянуті особливості виконання родами військ Повітряних Сил завдань з охорони повітряного простору та протиповітряного прикриття важливих державних і військових об’єктів, в умовах постійної загрози ракетного нападу на всій території України, а також завдань в операціях сил оборони. Запропоновані можливі напрямки розвитку Повітряних Сил Збройних Сил України та визначені першочергові заходи спрямовані підвищення спроможностей військових частин (підрозділів) Повітряних Сил.
Improvement of optimum pH and specific activity of pectate lyase from Bacillus RN.1 using loop replacement
Authors: Li Piwu , Wei Xiaofeng , Wang Yun , Liu Hui , Xu Yanpeng , Zhang Ziyang , Li Junlin , Wang Jianbin , Guo Chuanzhuang , Sui Songsen , Wang Junqing , Wang Ruiming 
Published: July 2023

Background: Alkaline pectate lyase plays an important role in papermaking, biological refining and wastewater treatment, but its industrial applications are largely limited owing to its low activity and poor alkali resistance.Methods: The alkaline pectate lyase BspPel from Bacillus RN.1 was heterologously expressed in Escherichia coli BL21 (DE3) and its activity and alkali resistance were improved by loop replacement. Simultaneously, the effect of R260 on enzyme alkaline tolerance was also explored.Results: Recombinant pectate lyase (BspPel-th) showed the highest activity at 60°C and pH 11.0, and showed significant stability over a wide pH range (3.0–11.0). The specific enzyme activity after purification was 139.4 U/mg, which was 4.4 times higher than that of the wild-type enzyme. BspPel-th has good affinity for apple pectin, since the Vmax and Km were 29 μmol/min. mL and 0.46 mol/L, respectively. Molecular dynamics simulation results showed that the flexibility of the loop region of BspPel-th was improved.Conclusion: The modified BspPel-th has considerable potential for industrial applications with high pH processes.
In vitro induction of Entamoeba gingivalis cyst-like structures from trophozoites in response to antibiotic treatment
Authors: Becker Christin , Adam Aysegül , Dommisch Henrik , Stach Thomas , Schaefer Arne S. 
Published: July 2023

BackgroundEntamoeba gingivalis (E. gingivalis) is an anaerobic protozoan that is strongly associated with inflamed periodontal pockets. It is able to invade the mucosal epithelium of the human host, where it can feed on epithelial cells and elicit a severe innate immune response. Unlike other Entamoeba species, it is considered that E. gingivalis cannot form cysts, because it is a non-infectious protozoan. The lack of encystation capability would make it susceptible to periodontal treatment. However, it is not clear how the human host becomes infected with E. gingivalis trophozoites. We investigated the ability of E. gingivalis to encapsulate in response to an unfavorable environment in vitro.MethodsDifferent strains of E. gingivalis, isolated from inflamed periodontal pocket samples, were cultured for 8 days in the presence or absence of the antimicrobials amoxycillin and metronidazole. To reveal cyst formation, we investigated the morphology and ultrastructure of the amoeba by light, fluorescence, transmission and scanning electron microscopy. We also used the fluorescent dye calcofluor white M2R to demonstrate chitin present in the cyst wall.ResultsWe observed exocysts and an intra-cystic space separating the encapsulated trophozoite from the environment. Remarkably, cysts showed a smooth surface, polygonal edges and smaller size compared to free-living trophozoites. In addition, encapsulated trophozoites that detached from the cyst wall had a dense cytoplasma without phagocytic vesicles. The cyst walls consisted of chitin as in other Entamoba species. The encapsulated trophozoids were mononuclear after antibioticinduced encapsulation.DiscussionWe conclude that E. gingivalis cyst formation has significant implications for dissemination and infection and may explain why established treatment approaches often fail to halt periodontal tissue destruction during periodontitis and peri-implantitis.
Molecular characterization and protective efficacy of vacuolar protein sorting 29 from Eimeria tenella
Authors: Shi Tuan-yuan , Li Tian-en , Hao Yun , Sun Hong-chao , Fu Yuan , Yan Wen-chao , Hao Li-li 
Published: July 2023

IntroductionVacuolar protein sorting 29 (VPS29) is a core component of the retromer-retriever complex and is essential for recycling numerous cell-surface cargoes from endosomes. However, there are no reports yet on VPS29 of Eimeria spp.MethodsHere, we cloned and prokaryotically expressed a partial sequence of Eimeria tenella VPS29 (EtVPS29) with RT-PCR and engineered strain of Escherichia coli respectively. The localization of the VPS29 protein in E. tenella sporozoites was investigated with immunofluorescence (IFA) and overexpression assays. And its protective efficacy against E. tenella infection was investigated in chickens with the animal protection test.ResultsAn EtVPS29 gene fragment with an ORF reading frame of 549 bp was cloned. The band size of the expressed recombinant protein, rEtVPS29, was approximately 39 kDa and was recognized by the chicken anti-E. tenella positive serum. EtVPS29 protein was observed widely distributing in the cytoplasm of E. tenella sporozoites in the IFA and overexpression assays. rEtVPS29 significantly increased average body weight gain and decreased mean lesion score and oocyst output in chickens. The relative weight gain rate in the rEtVPS29-immunized group was 62.9%, which was significantly higher than that in the unimmunized and challenged group (P &lt; 0.05). The percentage of reduced oocyst output in the rEtVPS29 immunized group was 32.2%. The anticoccidial index of the rEtVPS29-immunized group was 144.2. Serum ELISA also showed that rEtVPS29 immunization induced high levels of specific antibodies in chickens.DiscussionThese results suggest that rEtVPS29 can induce a specific immune response and is a potential candidate for the development of novel vaccines against E. tenella infections in chickens.
Spatial distribution characteristics, source analysis and risk assessment of polycyclic aromatic hydrocarbons in topsoil of a typical chemical industry park
Authors: Zhang Yongjiang , Niu Jiawei , Wei Zejun , Zhou Xunping , Wu Lijun , Li Xixi , Ma Shuang , Shi Ge 
Published: July 2023

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in soil and are difficult to degrade, posing a great threat to the ecological environment and human health. Therefore, research on the distribution characteristics and risks of PAHs is of great significance to protect human and ecosystem health. Taking a typical chemical industry park in Chongqing as an example, the spatial distribution characteristics of PAHs content in 54 topsoil samples in the typical area were analyzed, and the soil PAHs pollution was evaluated by incremental models such as single-factor index and Nemerow comprehensive index. A factor decomposition model Positive Definite Matrix Factorization (PMF) was used to analyze the sources of PAHs. The results showed that 16 kinds of optimally controlled PAHs were detected, and the content of ΣPAHs in the topsoil ranged from ND to 16.07 mg/kg, with an average value of 1.78 mg/kg; spatially, pollutant levels are higher in the south and southwest of the park as well as in the center; source analysis showed that Chongqing The PAHs pollution in this typical chemical industry park in the city is from coke combustion sources, traffic emission sources, biomass combustion sources, oil sources, coal combustion sources and oil leakage sources, and the contribution rates to PAHs are 10.7%, 35.2%, 20.7%, and 5.0%, 24.6%, and 3.7%; respectively. The health risk assessment of soil PAHs shows that there is no potential carcinogenic risk of PAHs in different age groups in this area, and the main exposure route of adults is dermal &gt; ingestion &gt; inhalation, and the main exposure route of children is ingestion &gt; dermal &gt; inhalation.
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature
Authors: Shen Lesang , Huang Huanhuan , Li Jiaxin , Chen Wuzhen , Yao Yao , Hu Jianming , Zhou Jun , Huang Fengbo , Ni Chao 
Published: July 2023

IntroductionLipid metabolic reprogramming is gaining attention as a hallmark of cancers. Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is closely related to lipid metabolism. Here, we focus on the estrogen receptor-positive (ER+) subtype, the most common subgroup of BC, to explore immunometabolism landscapes and prognostic significance according to lipid metabolism-related genes (LMRGs).MethodsSamples from The Cancer Genome Atlas (TCGA) database were used as training cohort, and samples from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), Gene Expression Omnibus (GEO) datasets and our cohort were applied for external validation. The survival-related LMRG molecular pattern and signature were constructed by unsupervised consensus clustering and least absolute shrinkage and selection operator (LASSO) analysis. A lipid metabolism-related clinicopathologic nomogram was established. Gene enrichment and pathway analysis were performed to explore the underlying mechanism. Immune landscapes, immunotherapy and chemotherapy response were further explored. Moreover, the relationship between gene expression and clinicopathological features was assessed by immunohistochemistry.ResultsTwo LMRG molecular patterns were identified and associated with distinct prognoses and immune cell infiltration. Next, a prognostic signature based on nine survival-related LMRGs was established and validated. The signature was confirmed to be an independent prognostic factor and an optimal nomogram incorporating age and T stage (AUC of 5-year overall survival: 0.778). Pathway enrichment analysis revealed differences in immune activities, lipid biosynthesis and drug metabolism by comparing groups with low- and high-risk scores. Further exploration verified different immune microenvironment profiles, immune checkpoint expression, and sensitivity to immunotherapy and chemotherapy between the two groups. Finally, arachidonate 15-lipoxygenase (ALOX15) was selected as the most prominent differentially expressed gene between the two groups. Its expression was positively related to larger tumor size, more advanced tumor stage and vascular invasion in our cohort (n = 149).DiscussionThis is the first lipid metabolism-based signature with value for prognosis prediction and immunotherapy or chemotherapy guidance for ER+ BC.
Analysis of M2 macrophage-associated risk score signature in pancreatic cancer TME landscape and immunotherapy
Authors: Yang Dashuai , Zhao Fangrui , Su Yang , Zhou Yu , Shen Jie , Zhao Kailiang , Ding Youming 
Published: July 2023

Background: M2 macrophages perform an influential role in the progression of pancreatic cancer. This study is dedicated to explore the value of M2 macrophage-related genes in the treatment and prognosis of pancreatic cancer.Methods: RNA-Seq and clinical information were downloaded from TCGA, GEO and ICGC databases. The pancreatic cancer tumour microenvironment was revealed using the CIBERSORT algorithm. Weighted gene co-expression network analysis (WGCNA) was used to detect M2 macrophage-associated gene modules. Univariate Cox regression, Least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate Cox regression were applied to develop the prognostic model. The modelling and validation cohorts were divided into high-risk and low-risk groups according to the median risk score. The nomogram predicting survival was constructed based on risk scores. Correlations between risk scores and tumour mutational load, clinical variables, immune checkpoint blockade, and immune cells were further explored. Finally, potential associations between different risk models and chemotherapeutic agent efficacy were predicted.Results: The intersection of the WGCNA results from the TCGA and GEO data screened for 317 M2 macrophage-associated genes. Nine genes were identified by multivariate COX regression analysis and applied to the construction of risk models. The results of GSEA analysis revealed that most of these genes were related to signaling, cytokine receptor interaction and immunodeficiency pathways. The high and low risk groups were closely associated with tumour mutational burden, immune checkpoint blockade related genes, and immune cells. The maximum inhibitory concentrations of metformin, paclitaxel, and rufatinib lapatinib were significantly differences on the two risk groups.Conclusion: WGCNA-based analysis of M2 macrophage-associated genes can help predict the prognosis of pancreatic cancer patients and may provide new options for immunotherapy of pancreatic cancer.
Identification of mitochondrial-related genes as potential biomarkers for the subtyping and prediction of Alzheimer’s disease
Authors: Ma Wenhao , Su Yuelin , Zhang Peng , Wan Guoqing , Cheng Xiaoqin , Lu Changlian , Gu Xuefeng 
Published: July 2023

IntroductionAlzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disorder prevalent among older adults. Although AD symptoms can be managed through certain treatments, advancing the understanding of underlying disease mechanisms and developing effective therapies is critical.MethodsIn this study, we systematically analyzed transcriptome data from temporal lobes of healthy individuals and patients with AD to investigate the relationship between AD and mitochondrial autophagy. Machine learning algorithms were used to identify six genes—FUNDC1, MAP1LC3A, CSNK2A1, VDAC1, CSNK2B, and ATG5—for the construction of an AD prediction model. Furthermore, AD was categorized into three subtypes through consensus clustering analysis.ResultsThe identified genes are closely linked to the onset and progression of AD and can serve as reliable biomarkers. The differences in gene expression, clinical features, immune infiltration, and pathway enrichment were examined among the three AD subtypes. Potential drugs for the treatment of each subtype were also identified.DiscussionThe findings observed in the present study can help to deepen the understanding of the underlying disease mechanisms of AD and enable the development of precision medicine and personalized treatment approaches.
Case Report: A case of hepatocellular carcinoma with aberrant right hepatic artery treated with transarterial chemoembolization and infusion chemotherapy separately to bilobar lesion combining with systemic therapies and sequential hepatectomy
Authors: Wei Yong-Guang , Su Hao , Lv Zi-li , Liao Xi-Wen , Zeng Zhi-Ming , Jia Yu-Xuan , Huang Hua-Sheng , Shen Xiao-Qiang , Zhu Guang-Zhi , Han Chuang-Ye , Ye Xin-Ping , Peng Tao 
Published: July 2023

BackgroundHepatocellular carcinoma (HCC) with a dismal prognosis is the second most deadly malignancy globally. Surgery is believed to be a curative approach. Nevertheless, there is still a considerable probability of postoperative recurrence. Most patients present in advanced stages with a surgically and oncologically unresectable disease. Systemic medicines are increasingly important to downstage the disease and further improve survival.Case summaryA 67-year-old Chinese man with uncontrolled hepatitis B was discovered to have liver masses with abnormal serum vitamin K absence or antagonist-II (PIVKA-II) level during checkup for upper abdominal discomfort. Abdominal multiphase computerized tomography (CT) and gadoxetate disodium–enhanced magnetic resonance imaging (MRI) showed the bulky bilobar HCCs of Barcelona Clinic Liver Cancer stage B and China Liver Cancer Staging stage IIa. Furthermore, the aberrant right hepatic artery (RHA) originates from the superior mesenteric artery. Due to the location being adjacent to important vasculatures and massive size of the right-sided lesion, curative resection appears to be challenging. To achieve a favorable surgical margin, repeated hepatic arterial infusion chemotherapy (HAIC) was adopted through the variant RHA, while transarterial chemoembolization (TACE) was delivered to the left lobe to arrest tumor growth. Furthermore, sintilimab plus lenvatinib served as the sequential systemic therapy. After 5 months of conversion treatment, the partial response with a decreased serum PIVKA-II level was attained. The R0 hepatectomy was then performed without postoperative complications. The immunohistochemistry and next-generation sequencing results suggested that the two-side HCCs existing tumor heterogeneity were not completely consistent. The patient continues to be without evidence of disease.ConclusionOur case highlights a favorable outcome in a man with bilobar bulky HCC after undergoing the comprehensive therapeutic schedule that includes personalized intervention and systemic drug therapy. In terms of conversion therapy, our case provides a secure and practical reference for managing unresectable bilobar HCC coexisting with the aberrant hepatic artery.