bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of specific pulmonary arterial hypertension therapy on cardiac fluorodeoxyglucose distribution in PET/MRI hybrid imaging–follow-up study
Authors: Kazimierczyk Remigiusz , Szumowski Piotr , Nekolla Stephan G. , Malek Lukasz A. , Blaszczak Piotr , Hladunski Marcin , Sobkowicz Bozena , Mysliwiec Janusz , Kaminski Karol A. 
Published: March 2023

Abstract
Background
PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic alterations are linked with hemodynamics and might precede clinical deterioration. Now, we hypothesize that adequate PAH therapy escalation may result in reversal of unfavourable increased glucose uptake of RV, which is associated with improved prognosis.

Methods
Out of twenty-six initially clinically stable PAH patients who had baseline PET/MRI scans, twenty (49.9 ± 14.9 years) had second PET/MRI after 24 months. SUVRV/SUVLV ratio was used to estimate and compare cardiac glucose uptake. Occurrences of clinical endpoints (CEP), defined as death or clinical deterioration, were assessed during 48-month follow-up from baseline.

Results
In first 24 months of observation, sixteen patients had CEP and needed PAH therapy escalation. At follow-up visits, we observed significant improvement of RV ejection fraction (45.1 ± 9.6% to 52.4 ± 12.9%, p = 0.01), mean pulmonary artery pressure (50.5 ± 18.3 to 42.8 ± 18.6 mmHg, p = 0.03), and SUVRV/SUVLV, which tended to decrease (mean change -0.20 ± 0.74). Patients with baseline SUVRV/SUVLV value higher than 0.54 had worse prognosis in 48 months observation (log-rank test, p = 0.0007); follow up SUVRV/SUVLV > 1 predicted CEP in the following 24 months, regardless of previously escalated treatment.

Conclusions
PAH therapy escalation may influence RV glucose metabolism, what seems to be related with patients’ prognosis. PET/MRI assessment may predict clinical deterioration regardless of previous clinical course, however its clinical significance in PAH requires further studies. Importantly, even mild alterations of RV glucose metabolism predict clinical deterioration in long follow-up.
Clinical Trial Registration ClinicalTrials.gov, NCT03688698, 05/01/2016, https://clinicaltrials.gov/ct2/show/study/NCT03688698?term=NCT03688698&draw=2&rank=1
GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint
Authors: Guo Dandan , Jin Chenxu , Gao Yaoxin , Lin Haizhen , Zhang Li , Zhou Ying , Yao Jie , Duan Yixin , Ren Yaojun , Hui Xinhui , Ge Yujia , Yang Renzheng , Jiang Wenzheng 
Published: March 2023

Abstract
Background
NK cell is one of innate immune cells and can protect the body from cancer-initiating cells. It has been reported that GPR116 receptor is involved in inflammation and tumors. However, the effect of GPR116 receptor on the NK cells remains largely unclear.

Results
We discovered that GPR116−/− mice could efficiently eliminate pancreatic cancer through enhancing the proportion and function of NK cells in tumor. Moreover, the expression of GPR116 receptor was decreased upon the activation of the NK cells. Besides, GPR116−/− NK cells showed higher cytotoxicity and antitumor activity in vitro and in vivo by producing more GzmB and IFNγ than wild-type (WT) NK cells. Mechanistically, GPR116 receptor regulated the function of NK cells via Gαq/HIF1α/NF-κB signaling pathway. Furthermore, downregulation of GPR116 receptor promoted the antitumor activity of NKG2D-CAR-NK92 cells against pancreatic cancer both in vitro and in vivo.

Conclusions
Our data indicated that GPR116 receptor had a negatively effect on NK cell function and downregulation of GPR116 receptor in NKG2D-CAR-NK92 cells could enhance the antitumor activity, which provides a new idea to enhance the antitumor efficiency of CAR NK cell therapy.
Leaf microbiome data for European beech (Fagus sylvatica) at the leaf and canopy scales collected in a gallery forest in South-West France
Authors: Fort Tania , Pauvert Charlie , Chancerel Emilie , Burlett Regis , Wingate Lisa , Vacher Corinne 
Published: March 2023

Key messageThe datasets describe bacterial and fungal communities of European beech (Fagus sylvatica) leaves collected along a vertical gradient in a gallery forest throughout the growing season. They also describe communities in the surrounding environment of beech trees. Dataset access is at https://doi.org/10.7910/DVN/FFHAQU, and associated metadata are available at https://metadata-afs.nancy.inra.fr/geonetwork/srv/fre/catalog.search#/metadata/f17fe848-fc3e-4297-be11-9871b35a1be4. Both can be used to uncover the dynamics and assembly processes of phyllosphere microbial communities in forest ecosystems.
Entrepreneurial intentions of Gen Z university students and entrepreneurial constraints in Bangladesh
Authors: Hossain Mohammad Imtiaz , Tabash Mosab I. , Siow May Ling , Ong Tze San , Anagreh Suhaib 
Published: March 2023

AbstractThis research examines a variety of restrictions preventing Bangladeshi youth, particularly Generation Z university students, from becoming involved in entrepreneurship. Moreover, the study examines the influence of Entrepreneurial Attitude (EA), Subjective Entrepreneurial Norms (SEN), Entrepreneurial Perceived Behavioural Control (EPBC), and Entrepreneurial Resilience (ER) on Entrepreneurial Intention (EI) of Bangladeshi Gen Z university students. A systematic literature review methodology following PRISMA procedure was performed to identify the relevant articles. A quantitative method with a positivism philosophy, cross-sectional time horizon and deductive approach was applied to the study. The data of 206 university students from the BBA department of ten universities were collected using convenience sampling and a self-administrated structured questionnaire survey. SPSS 26.0 and Smart PLS 3.0 were used to analyse the data. The output shows a positive and significant association amongst EA, SEN, EPBC, ER, and EI. Various constraints were identified from the literature and ranked based on the respondents’ feedback. This research will help entrepreneurs, scholars, policymakers and practitioners to build the entrepreneurial ecosystem and develop young people’s understanding of the entrepreneurial decision process and the importance of ER. This paper contributes through empirical investigation to an understanding of the actions that prevent Gen Z students from entrepreneurial activities; decisions are affected by socio-psychological constructions integrating ER with the Theory of Planned behaviour (TPB) model. Triple, Quadruple and Quintuple Helix models are considered supporting theories in this study to shed light on tackling the constraints. To the best knowledge of the researcher, integrating ER with TPB model’s constructs is a pioneer scholarly contribution in the context of South-East Asian, specifically Bangladeshi Gen Z students.
Antibiotic resistance in ocular bacterial infections: an integrative review of ophthalmic chloramphenicol
Authors: Bale Babatunde Ismail , Elebesunu Emmanuel Ebuka , Manikavasagar Pirakalai , Agwuna Favour Obianuju , Ogunkola Isaac Olushola , Sow Alhaji Umar , Lucero-Prisno Don Eliseo 
Published: March 2023

AbstractIntroductionChloramphenicol is a broad-spectrum antibiotic widely used for treating ophthalmic infections, but concerns about rising bacterial resistance to chloramphenicol have been observed due to its frequent use as an over-the-counter medication. This review assessed the common ophthalmic bacterial pathogens, their chloramphenicol resistance mechanisms, and rates of drug resistance.MethodsPubMed and Google Scholar databases were searched for relevant publications from the years 2000 to 2022, bordering on ophthalmic bacterial infections, chloramphenicol susceptibility profiles, and drug resistance mechanisms against chloramphenicol. A total of 53 journal publications met the inclusion criteria, with data on the antibiotic susceptibility profiles available in 44 of the reviewed studies, which were extracted and analyzed.ResultsThe mean resistance rates to chloramphenicol from antibiotic susceptibility profiles varied between 0% and 74.1%, with the majority of the studies (86.4%) showing chloramphenicol resistance rates below 50%, and more than half (23 out of 44) of the studies showed resistance rates lower than 20%. The majority of the publications (n = 27; 61.4%) were from developed nations, compared to developing nations (n = 14; 31.8%), while a fraction (n = 3; 6.8%) of the studies were regional cohort studies in Europe, with no country-specific drug resistance rates. No pattern of cumulative increase or decrease in ophthalmic bacterial resistance to chloramphenicol was observed.ConclusionsChloramphenicol is still active against ophthalmic bacterial infections and is suitable as a topical antibiotic for ophthalmic infections. However, concerns remain about the drug becoming unsuitable in the long run due to some proof of high drug resistance rates.
Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models
Authors: Margotta Cassandra , Fabbrizio Paola , Ceccanti Marco , Cambieri Chiara , Ruffolo Gabriele , D’Agostino Jessica , Trolese Maria Chiara , Cifelli Pierangelo , Alfano Veronica , Laurini Christian , Scaricamazza Silvia , Ferri Alberto , Sorarù Gianni , Palma Eleonora , Inghilleri Maurizio , Bendotti Caterina , Nardo Giovanni 
Published: March 2023

Abstract
Background
Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv background have a slow and fast disease progression rate, mimicking the variability observed in patients.
Based on evidence inferring the active influence of skeletal muscle on ALS pathogenesis, we explored whether dysregulation in hindlimb skeletal muscle reflects the phenotypic difference between the two mouse models.

Methods
Ex vivo immunohistochemical, biochemical, and biomolecular methodologies, together with in vivo electrophysiology and in vitro approaches on primary cells, were used to afford a comparative and longitudinal analysis of gastrocnemius medialis between fast- and slow-progressing ALS mice.

Results
We reported that slow-progressing mice counteracted muscle denervation atrophy by increasing acetylcholine receptor clustering, enhancing evoked currents, and preserving compound muscle action potential. This matched with prompt and sustained myogenesis, likely triggered by an early inflammatory response switching the infiltrated macrophages towards a M2 pro-regenerative phenotype. Conversely, upon denervation, fast-progressing mice failed to promptly activate a compensatory muscle response, exhibiting a rapidly progressive deterioration of muscle force.

Conclusions
Our findings further pinpoint the pivotal role of skeletal muscle in ALS, providing new insights into underestimated disease mechanisms occurring at the periphery and providing useful (diagnostic, prognostic, and mechanistic) information to facilitate the translation of cost-effective therapeutic strategies from the laboratory to the clinic.
Complex management of a large retroperitoneal undifferentiated sarcoma encasing the abdominal aorta in a pediatric patient: a case report and review
Authors: Teke Martha E. , Jacobson Jillian C. , Mutore Kevin , Murphy Joseph T. 
Published: March 2023

AbstractBackgroundRetroperitoneal undifferentiated sarcomas are rare, highly aggressive mesenchymal tumors with limited available treatment options. Surgical resection ± chemoradiation remains standard of care. However, in unique cases, challenging tumor biology, advanced tumor stage, and the morbidity required of an R0 resection can prohibit management and ultimate cure. Targeted therapies have an increasing role in this setting due to advances in molecular analytics.Case presentationHerein, we describe the management of an 11-year-old female with a chemotherapy-refractory large retroperitoneal sarcoma encasing the infrarenal aorta with a large acquired aortic pseudoaneurysm. This is the first report describing the complex approach to a retroperitonealNTRK-fusion ( +) undifferentiated sarcoma confounded by an acquired aortic pseudoaneurysm in a pediatric patient. Preoperative considerations, intra-operative technique, postoperative management, adjuvant therapies and a brief review of the literature are discussed.ConclusionOverall, a holistic understanding of the tumor biology and a cohesive multidisciplinary approach is integral to the care and long-term management of these cases.
Understanding nonlinear and synergistic effects of the built environment on urban vibrancy in metro station areas
Authors: Peng Jiandong , Hu Yiwen , Liang Chao , Wan Qiuyu , Dai Qi , Yang Hong 
Published: March 2023

AbstractTransit-oriented development (TOD) has long been recognized as a significant model for prospering urban vibrancy. However, most studies on TOD and urban vibrancy do not consider temporal differences or the nonlinear effects involved. This study applies the gradient boosting decision tree (GBDT) model to metro station areas in Wuhan to explore the nonlinear and synergistic effects of the built-environment features on urban vibrancy during different times. The results show that (1) the effects of the built-environment features on the vibrancy around metro stations differ over time; (2) the most critical features affecting vibrancy are leisure facilities, floor area ratio, commercial facilities, and enterprises; (3) there are approximately linear or complex nonlinear relationships between the built-environment features and the vibrancy; and (4) the synergistic effects suggest that multimodal is more effective at leisure-dominated stations, high-density development is more effective at commercial-dominated stations, and mixed development is more effective at employment-oriented stations. The findings suggest improved planning recommendations for the organization of rail transport to improve the vibrancy of metro station areas.
Amorphous topological matter: Theory and experiment
Authors: Corbae Paul , Hannukainen Julia D. , Marsal Quentin , Muñoz-Segovia Daniel , Grushin Adolfo G. 
Published: March 2023

Abstract
Topological phases of matter are ubiquitous in crystals, but less is known about their existence in amorphous systems, that lack long-range order. We review the recent progress made on defining amorphous topological phases, their new phenomenology. We discuss the open questions in the field which promise to significantly enlarge the set of materials and synthetic systems benefiting from the robustness of topological matter.
Temporal Surfacing: Mosori Monika (1970) and Chick Strand's Cross-Cultural Explorations
Authors: Pinar Ekin 
Published: March 2023

Abstract
This article considers how the temporality at work in Chick Strand's film Mosori Monika (US, 1970) breaks with the patriarchal, colonial, and capitalist narratives of genealogy, progress, and production. In Mosori Monika, an experimental ethnographic film that documents the swamps of Orinoco River in Venezuela, filmmaker Strand focuses her attention on the interactions between the Spanish Franciscan missionaries who came to the site in 1945 and the Warao who had little to no interaction with the outside world before the missionaries’ appearance. The film shows the competing realities and subjectivities of two women living in the area: a Franciscan nun, Sister Isabel, and an old Warao woman, Carmelita. Unlike the linear “exceptional artist beyond her time” narratives manifest in the recent spur of interest in Strand's body of work, the article explores the contemporary feel of Strand's film in relation to the transnational, cross-cultural, and affective ranges that go unnoticed when the scope of 1970s feminisms is painted in broad brushstrokes. Accordingly, the article emphasizes that Strand's nonteleological approach to history and ethnography in her film at once challenges the colonial, patriarchal gaze and its temporal distanciation and subjugation and invites us to reassess the linear feminist narratives of evolution, progress, and/or loss that often tend to rely on reductive historical periodization. Strand's filmmaking methods and style provide us with an alternative feminist historiographical model, “surfacing,” that highlights the productive resonances between then, now, and possible futures.
Menstrual Function, Eating Disorders, Low Energy Availability, and Musculoskeletal Injuries in British Servicewomen
Authors: O’LEARY THOMAS J. , COOMBS CHARLOTTE V. , PERRETT CAITLIN , DOUBLE REBECCA L. , KEAY NICKY , WARDLE SOPHIE L. , GREEVES JULIE P. 
Published: March 2023

ABSTRACT

Purpose
This study aimed to investigate associations between menstrual function, eating disorders, and risk of low energy availability with musculoskeletal injuries in British servicewomen.

Methods
All women younger than 45 yr in the UK Armed Forces were invited to complete a survey about menstrual function, eating behaviors, exercise behaviors, and injury history.

Results
A total of 3022 women participated; 2% had a bone stress injury in the last 12 months, 20% had ever had a bone stress injury, 40% had a time-loss musculoskeletal injury in the last 12 months, and 11% were medically downgraded for a musculoskeletal injury. Menstrual disturbances (oligomenorrhea/amenorrhea, history of amenorrhea, and delayed menarche) were not associated with injury. Women at high risk of disordered eating (Female Athlete Screening Tool score >94) were at higher risk of history of a bone stress injury (odds ratio (OR; 95% confidence interval (CI)), 2.29 (1.67–3.14); P < 0.001) and time-loss injury in the last 12 months (OR (95% CI), 1.56 (1.21–2.03); P < 0.001) than women at low risk of disordered eating. Women at high risk of low energy availability (Low Energy Availability in Females Questionnaire score ≥8) were at higher risk of bone stress injury in the last 12 months (OR (95% CI), 3.62 (2.07–6.49); P < 0.001), history of a bone stress injury (OR (95% CI), 2.08 (1.66–2.59); P < 0.001), a time-loss injury in the last 12 months (OR (95% CI), 9.69 (7.90–11.9); P < 0.001), and being medically downgraded with an injury (OR (95% CI), 3.78 (2.84–5.04); P < 0.001) than women at low risk of low energy availability.

Conclusions
Eating disorders and risk of low energy availability provide targets for protecting against musculoskeletal injuries in servicewomen.
Association between mutant E6 and E7 Human Papilloma Virus Type 16 oncogenes with cyclin D1 expression in cervical cancer: Observational study in Bali
Authors: Mahendra I Nyoman Bayu , Budiana I Nyoman Gede , Putra I Gede Mega , Suardika Anom , Wiradnyana Anak Agung Gede Putra , Sari Alisza Novrita 
Published: March 2023

Background: Incidence of cervical cancer is higher in low- and middle-income countries, including Indonesia. In Asia, Indonesia ranks second both in mortality and incidence of cervical cancer. Infection by Human Papilloma Virus (HPV) type 16 is a known risk factor, especially with mutations of the E6 or E7 oncogene that lead to chronic infection and malignancy. Increase in cyclin D1 expression is found on cervical cancer cells, including those resistant to chemotherapy. The role of cyclic D1 in increasing cellular proliferation and decreasing apoptosis leads to cervical cancer. Methods: This study was a cross-sectional observational study carried out between August 2020 until August 2021 at Prof. Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Bali, Indonesia. Samples were collected by consecutive sampling of eligible patients. Polyclinic patients newly diagnosed with cervical cancer and who gave informed consent were further examined. We determined their oncogene E6 and E7 HPV type 16 mutation patterns and their association with cyclin D1 expression using contingency coefficient correlation test. Other outcomes including age distribution, parturition history, BMI, pathological type, clinical stage, and E6/E7 mutation characteristics was also recorded. Results: We included 31 eligible subjects with cervical cancer and HPV type 16-positive, divided into mutant E6/E7 (n=12/31; 38.7%) and wild type (n=19/31;61.3%). Primary outcome of association between mutant oncogene and cyclin D1 expression was weak (c=0.283; p-value=0.1). Secondary outcome showed majority of age on 50 years old or over; normal or overweight BMI; squamous cell carcinoma was the most commonly found (n=28/31; 90%); and clinical stage II (n=18/31; 38%) in both groups. Conclusions: This study concluded that there is no association between mutation in the E6/E7 HPV type 16 oncogenes with cyclin D1 expression in patients with cervical cancer.
Presepsin and procalcitonin as markers of infectious respiratory diseases in children: a protocol for a scoping review of the literature
Authors: Sodero Giorgio , Mariani Francesco , Pulcinelli Valentina , Gentili Carolina , Valentini Piero , Buonsenso Danilo 
Published: March 2023

Background: Presepsin is a new inflammatory marker used in clinical practice for the diagnosis of severe bacterial infections, which might be used in combination or substitution of other classical indexes such as procalcitonin. Presepsin has been studied mainly in specific categories of patients (generally adults, critically ill patients or neutropenic children) to identify severe bacterial infections and to predict the mortality risk, while the role of this marker in discriminating bacterial from viral infections in otherwise healthy children of different age groups is less examined. This scoping review aims to better explore available evidence around the potential role of presepsin in pediatric respiratory infectious diseases, analyzing its ability to distinguish the severity and type of respiratory pathology and comparing it with a classic inflammation index such as procalcitonin. Methods: We started our research in February 2023 in the following bibliographic databases: PubMed, EMBASE, Cochrane and SCOPUS. The main review question will be “What is known about the diagnostic role of presepsin and/or procalcitoninin the differential diagnosis of respiratory tract infection’s severity and etiology?” We will include randomized and non-randomized controlled trials, prospective and retrospective observational studies, performed on children and adolescents (younger than 18 years), hospitalized or not, with a confirmed diagnosis of upper and/or lower respiratory infectious disease. We will include children diagnosed with pneumonia, bronchiolitis, bronchitis, croup, and other types of infectious respiratory diseases. To report our findings, we will follow Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist. Dissemination: The findings of this review will be published in a peer-reviewed journal and presented in national and international conferences.