bluuebunny/crossref_metadata_2025_split huggingface dataset:
Роль системи гідроген сульфіду в механізмах нефропротекторної дії метформіну за стрептозотоциніндукованого діабету
Authors: Струтинська О. Б. , Мельник А. В. 
Published: February 2023

Резюме. Діабетична нефропатія – поширене мікросудинне ускладнення цукрового діабету (ЦД), яке розвивається приблизно у 40 % хворих на ЦД 2 типу. З метою лікування діабетичного ураження нирок широко використовується «Метформін» – препарат, що контролює рівень глікемії та має доведені нефропротекторні властивості. На сьогодні не досліджено роль системи H2S у механізмах нефропротекторної активності метформіну.
Мета дослідження – оцінити вплив модуляторів обміну H2S на основні механізми нефропротекторної дії метформіну за експериментального цукрового діабету.
Матеріали і методи. Експериментальні дослідження проведено на 75 білих нелінійних щурах-самцях, яких поділили на 5 груп: перша – контроль; друга група – тварини з експериментальним ЦД, який ініціювали одноразовим інтраперитонеальним введенням стрептозотоцину (40 мг/кг маси); третя група – тварини з експериментальним ЦД, які з 3 до 28 доби отримували лікування метформіном (500 мг/кг/добу, інтрагастрально); четверта – щури з ЦД, яким метформін вводили разом з NaHS (56 мкмоль/кг/добу, інтрагастрально); п’ята група – тварини з ЦД, яким метформін вводили разом з пропаргілгліцином (ППГ, 442 мкмоль/кг/добу, інтрагастрально). У периферійній крові визначали вміст глюкози, а в супернатанті гомогенату нирок оцінювали рівень H2S, галектину-3, каспази-3, IL-1β, малонового діальдегіду (МДА), карбонільних груп протеїнів (КГП), активності НАДФН-оксидази та супероксиддисмутази (СОД).
Результати. Встановлено, що застосування метформіну за експериментально ЦД виявляло антиоксидантну (рівень МДА та КГП зменшувався на 24,7–27,4 %, p˂0,001), протизапальну (рівень IL-1β знижувався на 25,3 %, p˂0,001), антиапоптотичну (рівень каспази-3 зменшувався на 36,1 %, p˂0,001) та антифіброгенну (рівень галектину знижувався на 48,4 %, p˂0,001) дії у нирках, що асоціювалось зі збільшенням (на 27,9 %, p˂0,001) рівня H2S (│rs│= 0,59–0,75, p˂0,01). Використання модуляторів обміну H2S модифікувало нефропротекторні властивості метформіну за ЦД. Введення донора гідроген сульфіду NaHS потенціювало захисний вплив метформіну на нирки: рівні галектину-3, каспази-3, IL-1β, МДА та КГП у нирках були вірогідно меншими відповідно на 18–37 % (p˂0,001), ніж у тварин, які отримували лише метформін. Разом з тим, використання інгібітора синтезу гідроген сульфіду ППГ вірогідно зменшувало ренопротективну активність метформіну.
Висновки. Проведенні дослідження засвідчили вагому роль системи H2S у реалізації протизапальної, антифіброгенної, антиапоптотичної та антиоксидантної дій метформіну в нирках за ЦД. Поряд з цим, отримані результати патогенетично обґрунтовують доцільність використання донорів H2S для потенціювання нефропротекторних властивостей метформіну.
Advanced physical assessment as a course of studies for future masters of science in nursing at I. Horbachevsky Ternopil National Medical University
Authors: Krehkovska-Lepiavko O. M. , Lokay B. A. , Volkov R. K. 
Published: February 2023

Summary. Advanced research and assessment of the patient's health status plays a key role in the practice of a nurse. As autonomous, independent health care providers, nurses perform health assessments to evaluate patient needs and determine the best treatments. Advanced health assessment is a systematic process for evaluating the physical, mental and functional aspects of patient health. Mastering this diagnostic tool is vital to nurse`s practice because health assessment forms the basis of patient care
The aim of the study – to describe and analyze the academic program of the course Advanced Physical Assessment, branch of knowledge – 22 HEALTH CARE, specialty “223 NURSING”, training program “NURSING”, degree of higher education – Second (Master) level of higher education in the international students’ faculty of I. Horbachevsky TNMU.
Materials and Methods. It was described and analyzed both the training program and the academic program of the course of studies “Advanced Physical Assessment”, available for students of the second degree of higher education in the Institute of Nursing, I. Horbachevsky Ternopil National Medical University.
Results. The course of studies “Advanced Physical Assessment”, which was developed according to the requirements of the training program is aimed at development of systemic knowledge and understanding of conceptual foundations by students utilizing systematic history taking and the knowledge of therapeutic communication to elicit subjective data; collecting objective data; validating, analyzing and documentation of those data. This course ensures the acquisition of the appropriate competences and program learning outcomes, consists of lectures, training sessions and student`s independent work. It presents an overview of the full and comprehensive health assessment of patients across the life span. It emphasizes multiple aspects of advanced health assessment, including physical, functional and mental health assessment along with transcultural variations.
Conclusions. According to the requirements of the training program “Nursing” the course of studies “Advanced Physical Assessment” is available for students of the second (master) degree of higher education. The course of studies “Advanced Physical Assessment” consists of lectures (24 hours), training sessions (30 hours) and student’s independent work (126 hours). The course of studies “Advanced Physical Assessment” ensures the acquisition of the appropriate competences and program learning outcomes in accordance with the training program “Nursing”. The assessment of students` performance is evaluated using the criteria for assessment of students’ knowledge and skills.
Auto Insurance Fraud Detection with Multimodal Learning
Authors: Yang Jiaxi , Chen Kui , Ding Kai , Na Chongning , Wang Meng 
Published: February 2023

ABSTRACT
In recent years, feature engineering-based machine learning models have made significant progress in auto insurance fraud detection. However, most models or systems focused only on structural data and did not utilize multi-modal data to improve fraud detection efficiency. To solve this problem, we adapt both natural language processing and computer vision techniques to our knowledge-based algorithm and construct an Auto Insurance Multi-modal Learning (AIML) framework. We then apply AIML to detect fraud behavior in auto insurance cases with data from real scenarios and conduct experiments to examine the improvement in model performance with multi-modal data compared to baseline model with structural data only. A self-designed Semi-Auto Feature Engineer (SAFE) algorithm to process auto insurance data and a visual data processing framework are embedded within AIML. Results show that AIML substantially improves the model performance in detecting fraud behavior compared to models that only use structural data.
Synoptic-Scale Effects of Atmospheric Heat Source over Key Areas of the Tibetan Plateau on Its Downstream Rainfall in Summer
Authors: Fan Xuyan , Li Yueqing , Li Juan 
Published: February 2023

Abstract
This study demonstrates the synoptic-scale relationship between the atmospheric heat source over the Tibetan Plateau (TP) (TP<Q1>) and summer rainfall in eastern China. The results show that the summer TP<Q1> has three key areas [eastern, western, and northeastern TP (TPE, TPW, TPNE, respectively)] and 3–8-day dominant oscillation periods on the synoptic time scale for each subregion. Analogously, on the synoptic scale, the downstream rainfall of the TP in China has six sensitive regions (zone I to zone VI), each with 3–8-day dominant periods. The TPE<Q1>, TPW<Q1>, and TPNE<Q1> lead rainfall by 4 days with a southeastward propagation pathway, by 5 days with both southeastward and northeastward propagation routes, and by 4 days with an eastward route, respectively. Mechanistically, when TP<Q1> lies in the positive-to-negative transition phase, the rainfall moves off the TP and reaches the maximum in its most inactive phase; the jet cores embedded in the subtropical westerly jet band and the trough from the region of the TP<Q1> lead the eastward movement of the rainfall by the propagation of the divergence center and generalized moist potential vorticity. Besides, the southwest vortex and northwest vortex generated at the southeastern and northeastern flank of the TP are the main cause for the southeastward and northeastward or eastward movement of the precipitation. Further internal atmospheric dynamic structures indicate that both the horizontal moisture advection and generalized moist potential vorticity advection act on the entire propagation processes of the synoptic-scale signals for each TP<Q1> key area. In conclusion, the study has obvious theoretical significance and application value for the development of plateau synoptics.
Dynamics Governing a Simulated Bow-and-Arrow-Type Mesoscale Convective System
Authors: Zhang Shushi , Parsons David B. , Xu Xin , Sun Jisong , Wu Tianjie , Abulikemu Abuduwaili , Xu Fen , Chen Gang , Shen Wenqiang , Liu Lihang , Zhang Xidi , Zhang Kun , Zhang Wei 
Published: February 2023

Abstract
The bow-and-arrow Mesoscale Convective System (MCS) has a unique structure with two convective lines resembling the shape of an archer’s bow and arrow. These MCSs and their arrow convection (located behind the MCS leading line) can produce hazardous winds and flooding extending over hundreds of kilometers, which are often poorly predicted in operational forecasts. This study examines the dynamics of a bow-and-arrow MCS observed over the Yangtze–Huai Plains of China, with a focus on the arrow convection provided. The analysis utilized backward trajectories and Lagrangian vertical momentum budgets to simulations employing the WRF‐ARW and CM1 models. Cells within the arrow in the WRF-ARW simulations of the MCS were elevated, initially forming as convectively unstable air within the low-level jet (LLJ), which gently ascended over the cold pool and converged with the MCS’s mesoscale convective vortex (MCV) at higher altitudes. The subsequent ascent in these cells was enhanced by dynamic pressure forcing due to the updraft being within a layer where the vertical shear changed with height due to the superposition of the LLJ and the MCV. These dynamic forcings initially played a larger role in the ascent than the parcel’s buoyancy. These findings were bolstered by idealized simulations employing the CM1 model. These results illustrate a challenge for accurately forecasting bow-and-arrow MCSs as the updraft magnitude depends on dynamical forcing associated with the interaction between vertical shear associated with the environment and due to convectively generated circulations.
The Implementation of a Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Program at a Level 1 New England Trauma Center: Feasibility and Early Outcomes
Authors: Roderick Elizabeth , Ricaurte Daniel , Croteau Alfred , Gates Jonathan , Bass Stacy , Jain A.K. , Keating Jane 
Published: February 2023

Objectives We evaluated the feasibility of implementing a Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) program at our urban level 1 trauma center and evaluated early outcomes. Design A multidisciplinary committee including physicians (trauma surgery, emergency medicine, vascular surgery, and interventional radiology) and nurses created clinical practice guidelines for the placement of REBOA at our institution. All trauma surgeons and critical care board certified emergency medicine physicians were trained in placement and nurses received management training. A formal review process was implemented to identify areas for improvement. Finally, we instituted refresher training to maintain REBOA competency. Trauma patients with noncompressible torso hemorrhage from blunt or penetrating injuries who were partial or nonresponders to blood product resuscitation were included. Pregnant patients, children, or patients with significant hemothorax or suspected aortic or cardiac injury were excluded. Results Over seven months, eight catheters were successfully placed, all on the first attempt, including six in Zone 3 and two in Zone 1. All Zone 3 catheters were placed for pelvic fracture-related bleeding which were subsequently embolized. The Zone 1 catheters were placed immediately preoperatively for intraabdominal bleeding. Upon committee review, one critique was made regarding zone selection. One patient developed an arteriovenous fistula after placement which resolved without intervention. There were no other complications and all patients survived to discharge. Conclusions An REBOA program is feasible and safe following a comprehensive multidisciplinary effort. The efforts described here can be utilized by similar trauma programs for adaptation of this endovascular approach to bleeding control.
Challenges in Inter-rater Agreement on Lamina Propria Fibrosis in Esophageal Biopsies
Authors: Thaker Ameet I. , Smith Jacob , Pathak Mona , Park Jason Y. 
Published: February 2023

Background: Mucosal biopsies in eosinophilic esophagitis (EoE) can exhibit lamina propria (LP) fibrosis, which may portend stenotic complications; however, the histologic diagnosis of LP fibrosis is subjective. We sought to assess and improve the consistency of LP fibrosis diagnosis among our pathologist group. Methods: At a large pediatric hospital, 25 esophageal biopsy slides from 19 patients (16 with EoE) exhibiting a wide spectrum of LP area, artifacts, and fibrosis severity were scanned into whole-slide images. Staff pediatric pathologists (n = 8) separate from the authors classified each biopsy by LP adequacy and fibrosis severity 1 month before and after completion of an educational tutorial. Consensus was defined as >70% agreement. Results: At baseline, 16/25 (64%) cases reached consensus for no fibrosis (n = 3), fibrosis (n = 7), or inadequate LP (n = 6); agreement was fair (α = 0.34). Post-tutorial, 13/25 (52%) cases reached consensus for no fibrosis (n = 2), fibrosis (n = 7), or inadequate LP (n = 4); agreement was again fair (α = 0.33). There was moderate agreement in grading of fibrosis severity (α = 0.54). Conclusion: We document only fair-to-moderate agreement in the diagnosis of esophageal LP fibrosis and adequacy in a large pediatric pathologist group despite targeted education, highlighting a challenge in incorporating this feature into EoE research and clinical decision-making.
RPGRIP1 variant associated with pigmented paravenous chorioretinal atrophy
Authors: Bianco Lorenzo , Antropoli Alessio , Arrigo Alessandro , Saladino Andrea , Berni Alessandro , Bandello Francesco , Mansour Ahmad M , Parodi Maurizio Battaglia 
Published: February 2023

Purpose To report a case of Pigmented Paravenous Chorioretinal Atrophy (PPCRA) associated with a novel RPGRIP1 dominant variant. Methods Case report. The patient underwent multimodal retinal imaging, including spectral-domain optical coherence tomography (OCT), OCT Angiography (OCTA), blue-light autofluorescence (BAF), and ultra-widefield pseudocolor retinography and autofluorescence. Genetic testing was performed using next-generation sequencing. Results A 67-year-old male presented with a clinical suspicion of retinitis pigmentosa. His best-corrected visual acuity was 20/32 in the right eye and 20/200 in the left eye. On fundus examination, paravenous pigment clumping and chorioretinal atrophy were seen bilaterally, matching confluent hypoautofluorescent areas departing from the optic disc. This clinical presentation suggested a case of PPCRA. Genetic testing found a heterozygous deletion of nucleotide 631 (c.631del) in the RPGRIP1 gene, a frameshift variant that generates a premature stop codon (p.Ser211Valfs*64) and therefore results in a truncated or absent protein product. The variant was regarded as likely pathogenic (class IV). Conclusion In this report, we describe a case of PPCRA in association with a novel, likely pathogenic c.631del, p.Ser211Valfs*64 variant in RPGRIP1, a gene that has been associated with Leber congenital amaurosis and cone-rod dystrophy. Our case expands the spectrum of genes associated with PPCRA and prompts further studies to ascertain the molecular etiopathogenesis of this disease.
Lifestyle Elements for Improving Mental and Physical Health in Japanese University Students: Subjective Sleep Quality is a Common Key Factor
Authors: Fukuie Takemune , Inoue Koshiro , Yamaguchi Akihiko 
Published: February 2023

This study aimed to reveal the key lifestyle elements that improve physical and mental health in university students by focusing on physical activity, nutrition, and sleep. This cross-sectional study was conducted between October 2021 and December 2021. The participants were 290 first-year students (mean age, 18.63 ± .63 years; age range, 18 to 23; 198 female). The outcomes were daily step counts measured using accelerometers, dietary intake by nutrient category, sleep duration, subjective sleep quality, exercise frequency and duration by exercise type, screen time, depression level, and subjective fatigue by body part. Depression and subjective eye fatigue represent mental and physical health outcomes. Subjective sleep quality predicted depression (β = −1.22, P < .001) and eye fatigue (β = −.23, P < .01) in the path analysis. Participants with higher subjective sleep quality performed more frequent aerobic exercise ( P < .01), longer session times of physical relaxation exercise ( P < .05), and shorter screen time ( P < .05). Subjective sleep quality could be a key factor for high mental and physical health. Furthermore, performing aerobic and relaxation exercises and reducing screen time are important for improving the subjective sleep quality.
Laparoscopic partial pancreatectomy in a cat with exocrine pancreatic carcinoma
Authors: Menard Jenna , Buote Nicole J , Rivard Benjamin , Balkman Cheryl 
Published: February 2023

Case summary Minimally invasive surgery is an increasingly popular alternative to open surgery in veterinary medicine. Compared with traditional surgical approaches, laparoscopic pancreatectomy provides a less invasive approach and has several potential benefits, including improved visualization, reduced infection rate and decreased postoperative pain. Laparoscopic partial pancreatectomy has been described in humans, dogs and pigs but not cats. Pancreatectomy with or without chemotherapy is a treatment option for exocrine pancreatic carcinoma, a rare but malignant cancer in cats. We report the case of a 16-year-old male neutered domestic longhair cat diagnosed with exocrine pancreatic carcinoma that was treated with laparoscopic partial pancreatectomy, carboplatin and toceranib phosphate. A three-port technique using a 5 mm 0º telescope and bipolar vessel sealing device was performed to remove the entire left limb of the pancreas. No intra- or postoperative complications occurred, and the patient was discharged the following day. Forty days postoperatively, the patient received its first of five doses of carboplatin, which were given every 4–5 weeks over a period of 4 months. A maintenance protocol of toceranib phosphate was started after completion of carboplatin treatment. At the time of this article being submitted, the patient had survived for more than 221 days. Relevance and novel information This is the first report of a laparoscopic partial pancreatectomy performed on a feline patient for pancreatic carcinoma.
Minimal clinically important difference for impulse oscillometry in adults with asthma
Authors: Abdo Mustafa , Kirsten Anne-Marie , von Mutius Erika , Kopp Matthias , Hansen Gesine , Rabe Klaus F. , Watz Henrik , Trinkmann Frederik , Bahmer Thomas 
Published: February 2023

BackgroundImpulse oscillometry (IOS) allows an effort-independent evaluation of small airway function in asthma. Unfortunately, well-determined minimal clinically important differences (MCIDs) for IOS measures are lacking. Here, we provide MCIDs for frequently used IOS measures, namely frequency dependence of resistance (FDR) and area of reactance (AX), in patients with asthma.MethodsWe performed IOS at baseline and 1 year later in adult patients with mild-to-severe asthma (n=235). In a two-step approach, we first applied a distribution-based method to statistically determine the MCID. Next, we validated the proposed MCID according to patient-reported outcome measures (PROMs): Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Questionnaire-7 (ACQ-7) and Asthma Control Test (ACT). We used multivariable analyses to investigate the proposed MCIDs as predictors for improvements in PROMs compared with the established MCID of forced expiratory volume in 1 s (FEV1).ResultsThe proposed MCID was a decline of ≥0.06 kPa·L−1·s−1and ≥0.65 kPa·L−1for FDR and AX, respectively. Patients who had changes beyond the MCIDs for both FDR and AX showed greater improvements in all PROMs than those who had not. The mean improvements in PROMs were beyond the established MCIDs for ACQ-7 and AQLQ, and approximated the MCID for ACT. Multivariable analyses demonstrated the MCIDs for both FDR and AX as independent predictors for the MCIDs of all PROMs. The MCID for FDR was a stronger predictor of all PROMs than the MCID for FEV1.ConclusionsThis study provides MCIDs for IOS-derived measures in adult patients with asthma and emphasises that small airway function is a distinguished end-point beyond the conventional measure of FEV1.
Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice
Authors: Liang Yaohui , Song Chao , Li Jieli , Li Ting , Zhang Chunlei , Zou Yi 
Published: February 2023

Abstract
Background
The early craniofacial development is a highly coordinated process involving neural crest cell migration, proliferation, epithelial apoptosis, and epithelial-mesenchymal transition (EMT). Both genetic defects and environmental factors can affect these processes and result in orofacial clefts. Mutations in MID1 gene cause X-linked Opitz Syndrome (OS), which is a congenital malformation characterized by craniofacial defects including cleft lip/palate (CLP). Previous studies demonstrated impaired neurological structure and function in Mid1 knockout mice, while no CLP was observed. However, given the highly variable severities of the facial manifestations observed in OS patients within the same family carrying identical genetic defects, subtle craniofacial malformations in Mid1 knockout mice could be overlooked in these studies. Therefore, we propose that a detailed morphometric analysis should be necessary to reveal mild craniofacial dysmorphologies that reflect the similar developmental defects seen in OS patients.

Results
In this research, morphometric study of the P0 male Mid1-cKO mice were performed using Procrustes superimposition as well as EMDA analysis of the size-adjusted three-dimensional coordinates of 105 skull landmarks, which were collected on the bone surface reconstructed using microcomputed tomographic images. Our results revealed the craniofacial deformation such as the increased dimension of the frontal and nasal bone in Mid1-cKO mice, in line with the most prominent facial features such as hypertelorism, prominent forehead, broad and/or high nasal bridge seen in OS patients.

Conclusion
While been extensively used in evolutionary biology and anthropology in the last decades, geometric morphometric analysis was much less used in developmental biology. Given the high interspecies variances in facial anatomy, the work presented in this research suggested the advantages of morphometric analysis in characterizing animal models of craniofacial developmental defects to reveal phenotypic variations and the underlining pathogenesis.