bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sweet and simple as syrup: A review and guidance for use of novel antihyperglycemic agents for post‐transplant diabetes mellitus and type 2 diabetes mellitus after kidney transplantation
Authors: Lawrence S. Elise , Chandran Mary Moss , Park Jeong M. , Sweiss Helen , Jensen Thomas , Choksi Palak , Crowther Barrett 
Published: January 2023

AbstractUncontrolled type 2 diabetes mellitus (T2DM) and post‐transplant diabetes mellitus (PTDM) increase morbidity and mortality after kidney transplantation. Conventional strategies for diabetes management in this population include metformin, sulfonylureas, meglitinides and insulin. Limitations with these agents, as well as promising new antihyperglycemic agents, create a need and opportunity to explore additional options for transplant diabetes pharmacotherapy. Novel agents including sodium glucose co‐transporter 2 inhibitors (SGLT2i), glucagon‐like peptide‐1 receptor agonists (GLP1RA), and dipeptidyl peptidase IV inhibitors (DPP4i) demonstrate great promise for T2DM management in the non‐transplant population. Moreover, many of these agents possess renoprotective, cardiovascular, and/or weight loss benefits in addition to improved glucose control while having reduced risk of hypoglycemia compared with certain other conventional agents. This comprehensive review examines available literature evaluating the use of novel antihyperglycemic agents in kidney transplant recipients (KTR) with T2DM or PTDM. Formal grading of recommendations assessment, development, and evaluation (GRADE) system recommendations are provided to guide incorporation of these agents into post‐transplant care. Available literature was evaluated to address the clinical questions of which agents provide greatest short‐ and long‐term benefits, timing of novel antihyperglycemic therapy initiation after transplant, monitoring parameters for these antihyperglycemic agents, and concomitant antihyperglycemic agent and immunosuppression regimen management. Current experience with novel antihyperglycemic agents is primarily limited to single‐center retrospective studies and case series. With ongoing use and increasing comfort, further and more robust research promises greater understanding of the role of these agents and place in therapy for kidney transplant recipients.
Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar insulin N with US‐licensed Humulin® N formulation in healthy subjects: Results from the RHINE‐2 (Recombinant Human INsulin Equivalence‐2) study
Authors: Andersen Grit , Singh Gursharan , Murugesan Sundara Moorthi Nainar , Gogineni Rajesh , Sharma Nirant , Panda Jayanti , Marwah Ashwani , Loganathan Subramanian , Athalye Sandeep N. 
Published: January 2023

AbstractAimTo establish the pharmacokinetic (PK) and pharmacodynamic (PD) equivalence of proposed biosimilar Insulin N (Biocon's Insulin‐N; Biocon Biologics Ltd., Bangalore, India) and US‐licensed Humulin® N (Humulin‐N; Eli Lilly and Company, Indianapolis, IN, USA) in healthy subjects.Materials and MethodsThis was a phase‐1, single‐centre, double‐blind, randomized, three‐period, six‐sequence, partially replicated, crossover, 24‐h euglycaemic clamp study. Overall, 90 healthy subjects were randomized, of whom 85 completed the study. The subjects received either two single doses of Biocon's Insulin‐N and a single dose of Humulin‐N or two single doses of Humulin‐N and a single dose of Biocon's Insulin‐N subcutaneously at a dose of 0.4 IU/kg. The primary PK endpoints were the area under the insulin concentration‐time curve from 0 to 24 h (AUCins.0‐24h) and the maximum insulin concentration (Cins.max). The primary PD endpoints were the area under the glucose infusion rate (GIR) curve from 0 to 24 h (AUCGIR.0‐24h) and the maximum GIR (GIRmax).ResultsBiocon's Insulin‐N was found to be equivalent to Humulin‐N for the primary PK (geometric 90% confidence interval for the least squares mean ratio: AUCins.0‐24h, 100.98%‐115.66% and Cins.max, 95.91%‐110.16%) and PD endpoints (intra‐subject variability ≥0.294; 95% upper confidence interval [(μT – μR)2 − θσ2WR] <0; point estimates of geometric least squares mean ratio: AUCGIR.0‐24h, 104.61% and GIRmax, 100.81%). The safety profile of Biocon's Insulin‐N was similar to that of Humulin‐N, and no serious adverse events were reported.ConclusionPK and PD equivalence was shown between Biocon's Insulin‐N and Humulin‐N in healthy subjects, and both treatments were well tolerated and considered safe.
Pale tussock moth, Calliteara pudibunda (Linnaeus, 1758) (Lepidoptera; Erebidae) with a focus on its situation in Türkiye
Authors: Ipekdal Kahraman , Avcı Mustafa 
Published: January 2023

AbstractCalliteara pudibunda is a univoltine, polyphagous and native species producing periodic outbreaks which have been recorded only in Europe so far. Its larvae feed on the foliage of beech, oak and several other deciduous and coniferous trees. It is very widespread in Eurasia. In Europe, it is found between the 34th and 60th parallels. In Türkiye, it occurs mainly in coastal regions. Its outbreak range had been thought to be confined between the 48th and 57th parallels in Europe until the last two decades when outbreaks occurred in Italy and Türkiye. Therefore, the southern limit of its outbreak range can be updated as the 36th parallel. The outbreaks recur every 20–30 years, typically continue for 1–2 years, and end suddenly. Favourable meteorological conditions and a temporary rarity of parasitoids seem to be the main causes of the outbreaks. The damage on hosts is not evident until the third larval instar. The affected hosts may grow new shoots the next spring, as the larvae usually do not attack the terminal shoots. Increment loss is possible, but it may not be economically significant per se. However, tree mortality can occur with the combined effects of other stress factors. The impact of parasitoids and predators during the outbreaks is low. There are also fungal species identified from larvae and pupae, some of which might have significant potential in pest management. Additionally, Bacillus thuringiensis var. kurstaki (Btk), polyhedrosis viruses and light traps can potentially be used, although management practices are not recommended in C. pudibunda outbreaks.
Emerging Ideas: Is sibling aggression as scary as peer aggression in childhood and adolescence?
Authors: Tucker Corinna Jenkins , Finkelhor David , Turner Heather 
Published: January 2023

AbstractObjectiveWe compared the frequency of fearfulness for sibling versus peer victimization experiences (severe and minor physical, property, and psychological) in childhood and adolescence.BackgroundSibling aggression is not recognized as a childhood adversity. Yet a tenet of the family violence literature is that abuse is more fearsome when living with an abuser.MethodTelephone interviews were conducted with parents of children aged 1 to 9 years and with adolescents 10 to 17 years old living with a juvenile sibling (N = 7,029; 49% female) using data from three combined surveys of the National Survey on Children's Exposure to Violence.ResultsFear of sibling aggression was less common than peer aggression. Further, sibling aggression was less fearful than peer aggression for severe and minor physical and property episodes. There was little variation by gender, ethnicity, and parent education level.ConclusionsChildren and adolescents do not lack fear from sibling aggression, but the fear is lower than for peer aggression.ImplicationsA prevalent idea in the family violence literature that living with an offender generates more fear was not supported for sibling aggression.
Soil moisture determines the recovery time of ecosystems from drought
Authors: Yao Ying , Liu Yanxu , Zhou Sha , Song Jiaxi , Fu Bojie 
Published: January 2023

AbstractRecovery time, the time it takes for ecosystems to return to normal states after experiencing droughts, is critical for assessing the response of ecosystems to droughts; however, the spatial dominant factors determining recovery time are poorly understood. We identify the global patterns of terrestrial ecosystem recovery time based on remote sensed vegetation indices, analyse the affecting factors of recovery time using random forest regression model, and determine the spatial distribution of the dominant factors of recovery time based on partial correlation. The results show that the global average recovery time is approximately 3.3 months, and that the longest recovery time occurs in mid‐latitude drylands. Analysis of affecting factors of recovery time suggests that the most important environmental factor affecting recovery time is soil moisture during the recovery period, followed by temperature and vapour pressure deficit (VPD). Recovery time shortens with increasing soil moisture and prolongs with increasing VPD; however, the response of recovery time to temperature is nonmonotonic, with colder or hotter temperatures leading to longer recovery time. Soil moisture dominates the drought recovery time over 58.4% of the assessed land area, mostly in the mid‐latitudes. The concern is that soil moisture is projected to decline in more than 65% regions in the future, which will lengthen the drought recovery time and exacerbate drought impacts on terrestrial ecosystems, especially in southwestern United States, the Mediterranean region and southern Africa. Our research provides methodological insights for quantifying recovery time and spatially identifies dominant factors of recovery time, improving our understanding of ecosystem response to drought.
Unsilencing silence on business school sexism: A behind‐the‐scenes narration on regaining voice
Authors: Pérezts Mar , Mandalaki Emmanouela 
Published: January 2023

AbstractUnsilencing sexism‐related silence is not a new need, particularly in academic institutions heavily imbued with patriarchy, where sexist events are often ignored or denigrated. In this paper, we draw on a sexist cyberbullying attack unleashed against part of our academic work to extend a critique to the silence culture surrounding business school sexism. Through an embodied discussion of the various faces and phases of silence, silencing, and unsilencing that we experienced following this sexist event, we show the behind‐the‐scenes relational process that led us from silence to activism in regaining our voices and speaking out against academic sexism. We discuss the emancipating potential of feminist “wor(l)ds,” relationality, and communal support in unsilencing sexism‐related silence and articulate possible ways of unsilencing silence at the individual, community, and institutional levels.
Justice and utility: Approval of gender quotas to increase gender balance in top‐level managements—lessons from Iceland
Authors: Axelsdóttir Laufey , Einarsdóttir Þorgerður J. , Rafnsdóttir Guðbjörg Linda 
Published: January 2023

AbstractDespite the adoption of board gender quotas in several countries, little is known about the views on quotas outside the boards. In this article, we expand the dialogue about gender quotas by examining managers' arguments (justice and utility) for quotas as a measure to increase gender balance in top‐level managements. Drawing on a survey of 504 men and women managers in 244 of Iceland's largest companies, we show that social‐justice arguments and utility arguments make a stronger case for gender quotas than individual‐justice arguments. By highlighting the gendered context of arguments and expectations for further influence of gender quotas, we show that men managers' emphasis on liberal individualism and the lack of approval of quotas may hinder more organizational gender equality. We argue for the need to focus on organizational factors and top managers' responsibilities to support further gender balance in top‐level managements.
Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease
Authors: Fujii Hideki , Fujii Makoto , Iwaki Michihiro , Hayashi Hideki , Toyoda Hidenori , Oeda Satoshi , Hyogo Hideyuki , Kawanaka Miwa , Morishita Asahiro , Munekage Kensuke , Kawata Kazuhito , Tsutsumi Tsubasa , Sawada Koji , Maeshiro Tatsuji , Tobita Hiroshi , Yoshida Yuichi , Naito Masafumi , Araki Asuka , Arakaki Shingo , Kawaguchi Takumi , Noritake Hidenao , Ono Masafumi , Masaki Tsutomu , Yasuda Satoshi , Tomita Eiichi , Yoneda Masato , Kawada Norifumi , Tokushige Akihiro , Kamada Yoshihiro , Takahashi Hirokazu , Ueda Shinichiro , Aishima Shinichi , Sumida Yoshio , Nakajima Atsushi , Okanoue Takeshi ,   Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)
Published: January 2023

AbstractAimImpacts of platelet counts at the time of liver biopsy on hepatocellular carcinoma (HCC) development in patients with nonalcoholic fatty liver disease (NAFLD) remain unknown. The aim of this study was to investigate the prognostic value of platelet counts in patients with biopsy‐confirmed NAFLD using data from a multicenter study.MethodsOne thousand three hundred ninety‐eight patients were included in this subanalysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) in Asia study. Liver biopsy specimens were pathologically diagnosed, and histologically scored using the NASH Clinical Research Network system. Demographic, clinical, laboratory, and pathological data were collected.ResultsDuring a median follow‐up period of 4.6 years (range, 0.3–21.6 years), which corresponds to 8874 person‐years, 37 patients developed HCC. Using a cut‐off baseline platelet count of 192 × 109/L, the lower platelet group had a higher HCC rate than the higher platelet group (6.7% vs. 0.4%; p < 0.001). This cut‐off value significantly stratified the event‐free rate for HCC. Lower platelet counts were associated with an increased risk of HCC development. Relative to patients with platelet counts of 192 × 109/L, patients with platelet counts of 100 × 109/L had an unadjusted hazard ratio (HR) for HCC development of 7.37 (95% confidence interval [CI], 3.81–14.2) and an adjusted HR of 11.2 (95% CI, 3.81–32.7; p < 0.001), adjusting for age, sex, NASH, and diabetes.ConclusionsBaseline platelet counts of 192 × 109/L and lower are associated with a higher risk of developing HCC in patients with biopsy‐confirmed NAFLD and require active surveillance.
Robust and reliable solid oxide fuel cells with modified thin film YSZ electrolyte
Authors: Cheng Liya , Lyu Qiuqiu , Li Zongxun , Liu Yang , Jin Chao , Xu Na , Zhong Qin , Zhu Tenglong 
Published: January 2023

AbstractReduce electrolyte thickness can improve solid oxide fuel cell (SOFC) performance. However, thinner electrolyte often contains prominent defects and flaws, which may decrease the yield and increase operation risk. This work proposes a method to modify the thin film YSZ electrolyte, to improve cell reliability and durability. The as‐sintered anode supported half‐cell with screen printed YSZ electrolyte was immersed in precursor solution of Y(NO3)3·6H2O and Zr(NO3)4·5H2O, and being treated under hydrothermal condition of 150°C for 12 h. As a result, the modified cells show slight increase in the OCV values. Furthermore, the hydrothermal modification effectively promotes interface sintering between YSZ electrolyte and GDC barrier layer, yielding a smaller ohmic resistance of .142 Ω·cm2 (a decrease of ∼11%) and a higher peak power density of .964 W/cm2 (an increase of ∼18%) at 750°C, than pristine cell. Moreover, the modified cell operates stably over 300 h, while the pristine cell presents large and irregular voltage fluctuations. This work suggests that the hydrothermal modification is an effective and promisingly industrial applicable method for thin film electrolyte recovery in SOFCs.
Spark plasma sintering of (5RE.2)Ta3O9 high‐entropy ceramics and their thermal properties
Authors: Wei Zicheng , Yang Qingqing , Meng Bin , Li Chen , Ping Xinyu , Fang Congcong , Zhang Han 
Published: January 2023

AbstractSix rare‐earth tantalate high‐entropy ceramics of (5RE.2)Ta3O9 (RE represents any five elements selected from La, Ce, Nd, Sm, Eu, Gd) were designed and prepared by spark plasma sintering process at 1400°C in this study. The (5RE.2)Ta3O9 ceramics only consist of a single‐phase solid solution with perovskite structure. Their relative densities are all above 90%, and the average grain size is in the range of 1.47–2.92 μm. The thermal conductivity of (5RE.2)Ta3O9 ceramics is in 2.24–1.90 W m−1 K−1 (25°C–500°C), which is much lower than that of yttria‐stabilized zirconia. In six samples, (La.2Nd.2Sm.2Gd.2Eu.2)Ta3O9 possesses a thermal conductivity of 1.90 W m−1 K−1, a thermal expansion coefficient of 3.47 × 10−6 K−1 (500°C), a Vickers hardness of about 7.33 GPa, and a fracture toughness of about 5.20 MPa m1/2, which are suitable for its application as thermal barrier coatings.
Point‐of‐care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers
Authors: Armstrong David G. , Edmonds Michael E. , Serena Thomas E. 
Published: January 2023

AbstractElevated levels of bacteria, including biofilm, increase the risk of chronic wound infection and inhibit healing. Addressing asymptomatic high bacterial loads is challenged by a lack of clinical terminology and diagnostic tools. This post‐hoc multicenter clinical trial analysis of 138 diabetic foot ulcers investigates fluorescence (FL)‐imaging role in detecting biofilm‐encased and planktonic bacteria in wounds at high loads. The sensitivity and specificity of clinical assessment and FL‐imaging were compared across bacterial loads of concern (104–109 CFU/g). Quantitative tissue culture confirmed the total loads. Bacterial presence was confirmed in 131/138 ulcers. Of these, 93.9% had loads >104 CFU/g. In those wounds, symptoms of infection were largely absent and did not correlate with, or increase proportionately with, bacterial loads at any threshold. FL‐imaging increased sensitivity for the detection of bacteria across loads 104–109 (P < .0001), peaking at 92.6% for >108 CFU/g. Imaging further showed that 84.2% of ulcers contained high loads in the periwound region. New terminology, chronic inhibitory bacterial load (CIBL), describes frequently asymptomatic, high bacterial loads in diabetic ulcers and periwound tissues, which require clinical intervention to prevent sequelae of infection. We anticipate this will spark a paradigm shift in assessment and management, enabling earlier intervention along the bacterial‐infection continuum and supporting improved wound outcomes.
Simultaneously achieving high energy storage performance and low electrostrictive strain in BT‐based ceramics
Authors: Wei Fangbin , Yang Yule , Zhang Leiyang , Alikin Denis , Shur Vladimir , Zhang Amei , Du Hongliang , Wei Xiaoyong , Jin Li 
Published: January 2023

AbstractDielectric ceramics with high recoverable energy storage density (Wrec) and high energy storage efficiency (η) are urgently needed due to their potential application in pulse capacitor devices. However, the low η and breakdown strength (BDS) have produced a bottleneck for achieving high Wrec at high electric field. Here, we introduce Bi(Mg0.5Ti0.5)O3 (BMT) into Ba(Ti0.92Sn0.08)O3 (BTS) matrix to enhance the relaxor character of BTS–xBMT and reduce the electrostrictive strain generated during electric field loading. The enhanced relaxor character is beneficial for increasing the efficiency, whereas the reduced electrostrictive strain is profitable to increase the BDS. Furthermore, the BDS is significantly improved by the polymer viscous rolling process. Finally, the electrostrictive effect was considerably lowered in an optimized BTS–0.1BMT composition. More crucially, a high Wrec of 4.34 J/cm3 was attained accompanied by excellent temperature stability (variation ≤±5% between 30 and 120°C). The current results show that the developed dielectric ceramics can be used in pulse capacitor devices for energy storage.
Actinide and lanthanide dioxide lattice dilatation mechanisms with defect ingrowths
Authors: Günay Seçkin D. 
Published: January 2023

AbstractThe effects of irradiation‐induced defects on the fluorite‐structured dioxide materials were investigated in the literature and explained with complex physical phenomena. An interpretation that can simply explain their effects on the structure has not been put forward so far. However, in a recent atomistic simulation study, a specific defect was found to be directly responsible for the α‐particle irradiated UO2 lattice dilatation, and there was a linear relationship between them. It was also determined that this linear equation has two different slopes at low and high defect concentrations. In this paper, it was found that these phenomenon were not specific to UO2 and applicable to all fluorite‐structured actinide and lanthanide dioxides studied here (CmO2, AmO2, CeO2, UO2, NpO2, PuO2, ThO2). The findings provide clues to the existence of more general law. The results have the potential to lead to significant improvements, such as why different radiation types (α‐particle, α‐decay, fission) swell the lattice at different saturation levels.
Effect of test parameters in the exposure of Ca–Mg–Al–silicate on yttria stabilized zirconia
Authors: Kowalski Benjamin , Stokes Jamesa , Albert Patrick E. , Lauer Pete E. , Wolfe Douglas E. 
Published: January 2023

AbstractJet engine components need protective coatings to function against both high‐temperature and environmental effects. Ingested calcium–magnesium–aluminosilicates (CMAS) dust particulates are extremely detrimental to the life of the coatings. However, many methods exist to investigate the infiltration of CMAS into these coatings with each method exploring a different aspect of the degradation process. To probe the overlap in these methods, this study focuses on the effect of grain size, areal density, and aspect ratio on the infiltration of CMAS into yttria stabilized zirconia. The infiltration depths ranged from 6 up to 85 µm depending on the test conditions.