bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelación matemática de frecuencias óptimas de inspecciones de mantenimiento para tornos paralelos en función del contexto operacional
Authors: López Telenchana Luis Stalin , Ramos Araujo Cristina Estefanía , Pérez Londo Natalia Alexandra , Moyón Moyón Carmen del Rocio 
Published: September 2023

La optimización de frecuencias de mantenimiento utilizando el pronóstico de ocurrencia de fallas resultado de modelación matemática y en particular a través del empleo de Modelos Autorregresivos Integrado de Promedio Móvil (ARIMA) es un tema que ha venido siendo investigado y desarrollado en los últimos años, debido a que los resultados obtenidos reflejan el aumento de los distintos índices de productividad de las máquinas y equipos intervenidos, es decir se ha comprobado la eficacia, la eficiencia y la efectividad que tiene dichos modelos en la estimación de dichas frecuencias. Se ha aplicado una metodología que parte de la generación de una serie temporal en función de los Tiempos de Buen Funcionamiento (TTF) que se encuentran registrados en las bitácoras de mantenimiento del torno paralelo TR - 01, esta serie es modelada matemáticamente con el objetivo de generar un pronóstico adecuado de la aparición de nuevas fallas, esto permitió reducir indicadores clave de desempeño a nivel industrial como el Tiempo Medio de Reparación y los Costos de Mantenimiento hasta en un 35%, además la repetibilidad y la reproducibilidad de metodología planteada hace que el estudio se pueda implementar en cualquier activo físico.
PENGENALAN DATA DAN LOGIKA: KECERMATAN BERBISNIS JANGKA PANJANG BAGI SISWA/I SMK YADIKA BANDARLAMPUNG
Authors: Novita Dian , Putri Almira Devita , Maskar Sugama 
Published: September 2023

Generasi Z adalah generasi anak-anak dari orang tua yang merupakan Gen millenial , mereka membawa beberapa sifat bawaan Millenial antara lain setia, tegas, bertanggungjawab dan perduli namun bedanya GEN Z lebih memiliki jiwa kewirausahaan yang tinggi serta cenderung untuk berjuang keras demi memperoleh identitas dirinya dan mendapatkan pengakuan dari orang lain (Chillakuri Mahanandia, 2018) dan Gen Z juga berkontribusi 85% dari total transaksi (KIC-Kredivo, 2020). Lebih lanjut, pemerintah saat ini tengah fokus dalam pemulihan ekonomi nasional yang turun karena pandemik Covid-19 yang belum mereda. Generasi Z yang diharapkan menjadi bonus demografi tenaga kerja beberapa tahun kedepan, sebaiknya sebagaimana dalam penelitian Mahanandia yang menyarankan bahwa bakat GEN Z perlu dikembangkan, oleh karena itu sangat tepat untuk membekali siswa/I SMK yang faktanya merupakan GEN Z dengan motivasi pengembangan potensi diri untuk menjalankan bisnis di era digital dan juga mengasah logika berfikirnya dengan statistik sebagai alat analisis bisnis. Pengabdian Kepada Masyarakat ini dilakukan dengan tujuan membuka wawasan siswa/i untuk mengenali potensi diri, membangun bisnis yang berawal dari hobi sendiri, serta memperkenalkan siswa pada data statistic. Tidak hanya itu saja, melalui kegiatan ini siswa juga akan diajarkan bagaimana cara membangun bisnis di era digital, dengan demikian diharapkan siswa memiliki daya saing yang baik serta mampu berkontribusi tidak hanya untuk diri sendiri dan keluarga, namun masyarakat sekitarnya
Pemetaan Lahan Area Bekas Penambangan Wilayah Desa Tanjung Riu, Kabupaten Gunung Mas, Provinsi Kalimantan Tengah
Authors: Putrawiyanta I Putu , Noveriady  , Novalisae  , Ferdinandus  , Fidayanti Neny , Kristianie Yunitae 
Published: September 2023

Desa Tanjung Riu merupakan salah satu Desa di Kecamatan Kurun, Kabupaten Gunung Mas, Provinsi Kalimantan Tengah. Kawasan Desa Tanjung Riu memiliki potensi lahan dari bekas kegiatan pertambangan yang meninggalkan lubang bekas tambang (kolong) yang terisi air. Pemetaan lahan bekas pertambangan dilakukan untuk memudahkan pemerintah desa dan masyarakat untuk menata dan memanfaatkan lahan bekas pertambangan agar dapat meningkatkan pendapatan secara ekonomi bagi masyarakat di Desa Tanjung Riu. Pemetaan dimulai dengan observasi wilayah batas desa, menentukan titik lokasi area lahan bekas kegiatan pertambangan dengan GPS, serta menentukan titik adminitrasi desa, seperti area Perkantoran Desa, area Pendidikan, Rumah Ibadah, Puskesmas dan Posyandu, dengan hasil hampir 40% merupakan lahan terlantar bekas kegiatan Pertambangan, kemudian 50% didominasi Hutan atau Kebun Masyarakat seperti Karet dan Buah-buahan, kemudian 10% terisi oleh pemukiman. Hasil pemetaan diketahui lahan bekas pertambangan yang ada diwilayah Desa Tanjung Riu masih dapat dikelola untuk pemanfaatan lainnya seperti tempat wisata maupun tempat budidaya ikan.
Asuhan Kebidanan Berkelanjutan (Continuity Of Care) Dengan Anemia Ringan Pada Ibu Hamil
Authors: Yuliani Erni , Fitriani Ardhita 
Published: September 2023

Berdasarkan hasil survei di PMB Bd. Riyanti ditemukan data ibu hamil yang mengalami anemia sebanyak 30 ibu hamil. Sehingga perlu adanya pengabdian masyarakat dalam pemberian asuhan berkelanjutan mulai dari kehamilan Trimester I sampai dengan masa nifas. Metode: menggunakan studi kasus yaitu observasional deskriptif. Hasil: Selama kehamilan, Ny.L melakukan 4 kali kunjungan dan selama trimester II Ny.L mengalami anemia ringan. Oleh karena itu penulis memberikan terapi jus buah naga, karena jus buah naga dapat meningkatkan hemoglobin karena 100 gram buahnya mengandung 0,16 mg zat besi. Pada trimester III Ny.L mengalami nyeri punggung. Penulis kemudian memberikan terapi berupa Efflurage massage untuk memberikan rasa nyaman, relaksasi, dan merangsang produksi endorphin untuk mengurangi rasa sakit secara alami. Selain itu asuhan bayi pasca lahir serta masa nifas semuanya dalam batas normal. Kesimpulan: Asuhan kebidanan yang diberikan secara berkelanjutan hemoglobin pada ibu hamil mengalami peningkatan dan nyeri punggung sudah teratasi.
THE ROLE OF YOUNG PEOPLE IN REALIZING GENDER EQUALITY IN THE MIDST OF STRONG PATRIARCHAL CULTURE IN NTT AND PAPUA
Authors: Rudi Kogoya  
Published: September 2023

This paper discusses the role of young people in realizing gender equality in the midst of a strong patriarchal culture in two regions of Indonesia, namely East Nusa Tenggara and Papua. The strong patriarchal culture in East Nusa Tenggara and Papua causes women to experience violence in the home to the household. From the data obtained, domestic violence (KDRT) that occurred in East Nusa Tenggara was caused by the existence of belis in NTT and the influence of dowry on Papuan women so that there was a sense of male authority over these women. The rate of violence has increased over the years and this requires a serious subscription both from the government and from the community. This paper uses qualitative methods with case studies, interviews and documentation studies through journals, books and research results. To minimize violence against women, it is necessary to have the role of young people in the family, education and society through the socialization of the importance of gender equality in the family and society.

Keywords: Role of Youth, Gender Equality, Patriarchal Culture, NTT, Papua
ANALISA CYCLIC VOLTAMMETRY GUNA RECOVERY TEMBAGA PADA LIMBAH ELEKTRONIK PRINTED CIRCUIT BOARDS (PCB) MENGGUNAKAN RELINE
Authors: Sugondo Ebeng , Wijaya Andy , Proklamanto Aan Subekti , Reziana Fedika Gita , Etnanta Fatiha Nur 
Published: September 2023

Cyclic voltammetry analysis for copper recovery on printed circuit boards (PCB) electronic waste using Reline (ChCl: Thiourea) has been successfully carried out. The use of Reline solution (ChCl: Thiourea) is included in the deep eutectic solvent (DES) as an alternative for the use of solvents that are cheap, efficient, and safe for the environment. The solvent is formed from a donor (HBD) and acceptor (HBA) bonds with a ratio of 1 mol: 2 mol to water which will produce a eutectic mixture. The results of XRF (X-ray fluorescence spectrometry) on the printed circuit board (PCB) after comminution obtained the highest element, namely copper at 17.91%, and became the object of research observation. All experiments on the cyclic voltammetry test produced irreversible type voltammograms. The addition of more than 50% water in the deep eutectic solvent (DES) affects the peaks of oxidation and reduction, and in theory, the current efficiency is 99.83% and the optimum test results occur at a temperature of 60 oC for testing the Reline type deep eutectic solvent (DES) solution (ChCl: Thiourea) with a potential of Ep = 4.2975 volts and Ep/2 = 4.2971 volts. SEM-EDX analysis results on a platinum plate (Pt) from deep eutectic solvent (DES) ChCl: Thiourea (Reline) capable of spontaneously depositing copper minerals onto the surface of the platinum plate (Pt).
Keywords: Reline, Cyclic Voltammetry, Solvent
Procedural outcome & risk prediction in young patients undergoing transvenous lead extraction—a GALLERY subgroup analysis
Authors: Rexha Enida , Chung Da-Un , Burger Heiko , Ghaffari Naser , Madej Tomas , Ziaukas Virgilijus , Hassan Kambiz , Reichenspurner Hermann , Gessler Nele , Willems Stephan , Butter Christian , Pecha Simon , Hakmi Samer 
Published: September 2023

BackgroundThe prevalence of young patients with cardiac implantable electronic devices (CIED) is steadily increasing, accompanied by a rise in the occurrence of complications related to CIEDs. Consequently, transvenous lead extraction (TLE) has become a crucial treatment approach for such individuals.ObjectiveThe purpose of this study was to examine the characteristics and procedural outcomes of young patients who undergo TLE, with a specific focus on identifying independent risk factors associated with adverse events.MethodsAll patients in the GALLERY (GermAn Laser Lead Extraction RegistrY) were categorized into two groups based on their age at the time of enrollment: 45 years or younger, and over 45 years. A subgroup analysis was conducted specifically for the younger population. In this analysis, predictor variables for all-cause mortality, procedural complications, and procedural failure were evaluated using multivariable analyses.ResultsWe identified 160 patients aged 45 years or younger with a mean age of 35.3 ± 7.6 years and 42.5% (n = 68) female patients. Leading extraction indication was lead dysfunction in 51.3% of cases, followed by local infections in 20.6% and systemic infections in 16.9%. The most common device to be extracted were implantable cardioverter-defibrillators (ICD) with 52.5%. Mean number of leads per patient was 2.2 ± 1.0. Median age of the oldest indwelling lead was 91.5 [54.75–137.5] months. Overall complication rate was 3.8% with 1.9% minor and 1.9% major complications. Complete procedural success was achieved in 90.6% of cases. Clinical procedural success rate was 98.1%. Procedure-related mortality was 0.0%. The all-cause in-hospital mortality rate was 2.5%, with septic shock identified as the primary cause of mortality. Multivariable analysis revealed CKD (OR: 19.0; 95% CI: 1.84–194.9; p = 0.018) and systemic infection (OR: 12.7; 95% CI: 1.14–142.8; p = 0.039) as independent predictor for all-cause mortality. Lead age ≥ 10 years (OR: 14.58, 95% CI: 1.36–156.2; p = 0.027) was identified as sole independent risk factor for procedural complication.ConclusionTLE in young patients is safe and effective with a procedure-related mortality rate of 0.0%. CKD and systemic infection are predictors for all-cause mortality, whereas lead age ≥ 10 years was identified as independent risk factor for procedural complications in young patients undergoing TLE.
Complement factor D regulates collagen type I expression and fibroblast migration to enhance human tendon repair and healing outcomes
Authors: Chen Junyu , Wang Jin , Hart David A. , Zhou Zongke , Ackermann Paul W. , Ahmed Aisha S. 
Published: September 2023

IntroductionDense connective tissues (DCTs) such as tendon, ligament, and cartilage are important stabilizers and force transmitters in the musculoskeletal system. The healing processes after DCT injuries are highly variable, often leading to degenerative changes and poor clinical outcome. Biomarkers in relation to repair quality for human DCTs, especially tendon are lacking. This study expands our previous findings and aimed to characterize the mechanisms by which a potential biomarker of good outcomes, complement factor D (CFD), regulates tendon healing. MethodsQuantitative mass spectrometry (QMS) profiling of tissue biopsies from the inflammatory phase of healing (n = 40 patients) and microdialysates from the proliferative phase of healing (n = 28 patients) were used to identify specific biomarkers for tendon healing. Further bioinformatic and experimental investigations based on primary fibroblasts and fibroblast cell line were used to confirm the identified biomarkers.ResultsThe QMS profiling of tissue biopsies from the inflammatory phase of healing identified 769 unique proteins, and microdialysates from the proliferative phase of healing identified 1423 unique proteins in Achilles tendon rupture patients. QMS-profiling showed that CFD expression was higher during the inflammatory- and lower during the proliferative healing phase in the good outcome patients. Further bioinformatic and experimental explorations based on both inflammatory and proliferative fibroblast models demonstrated that CFD potentially improved repair by regulating cell migration and modulating collagen type I (Col1a1) expression. Moreover, it was shown that the enhanced Col1a1 expression, through increased fibroblast migration, was correlated with the validated clinical outcome. DiscussionThe results of the current studies characterized underlying inflammatory- and proliferative healing mechanisms by which CFD potentially improved tendon repair. These findings may lead to improved individualized treatment options, as well the development of effective therapies to promote good long-term clinical outcomes after tendon and other DCT injuries. Trial registrationhttp://clinicaltrials.gov, identifiers NCT02318472, NCT01317160.
CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease
Authors: Lin Ziyue , Lv Dan , Liao Xiaohui , Peng Rui , Liu Handeng , Wu Tianhui , Wu Keqian , Sun Yan , Zhang Zheng 
Published: September 2023

IntroductionInflammatory cell infiltration is a novel hallmark of diabetic kidney disease (DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial cell communication may play an important role in renal fibrosis. Circular RNAs (circRNAs) have been reported in the pathogenesis of various human diseases involving macrophages activation, including DKD. However, the exact mechanism of circRNAs in macrophage infiltration and renal fibrosis of DKD remains obscure.MethodsIn our study, a novel circRNA circUBXN7 was identified in DKD patients using microarray. The function of circUBXN7 in vitro and in vivo was investigated by qRT-PCR, western blot, and immunofluorescence. Finally, a dual-luciferase reporter assay, ChIP, RNA pull-down, RNA immunoprecipitation and rescue experiments were performed to investigate the mechanism of circUBXN7.ResultsWe demonstrated that the expression of circUBXN7 was significantly upregulated in the plasma of DKD patients and correlated with renal function, which might serve as an independent biomarker for DKD patients. According to investigations, ectopic expression of circUBXN7 promoted macrophage activation, EMT and fibrosis in vitro, and increased macrophage infiltration, EMT, fibrosis and proteinuria in vivo. Mechanistically, circUBXN7 was transcriptionally upregulated by transcription factor SP1 and could reciprocally promote SP1 mRNA stability and activation via directly binding to the m6A-reader IGF2BP2 in DKD.ConclusionCircUBXN7 is highly expressed in DKD patients may provide the potential biomarker and therapeutic target for DKD.
Vertical distributions of organic matter components in sea ice near Cambridge Bay, Dease Strait, Canadian Archipelago
Authors: Kim Kwanwoo , Ha Sun-Yong , Shin Kyung-Hoon , Kim Jee-Hoon , Mundy C. J. , Dalman Laura A. , Kim Bo Kyung , Lee Dabin , Jang Hyo Keun , Kim Yejin , Park Sanghoon , Lee Sang Heon 
Published: September 2023

Ice algae thriving within sea ice play a crucial role in transferring energy to higher trophic levels and influencing biogeochemical processes in polar oceans; however, the distribution of organic matter within the ice interior is not well understood. This study aimed to investigate the vertical distribution of organic matter, including chlorophyll a (Chl-a), particulate organic carbon and nitrogen (POC and PON), carbohydrates (CHO), proteins (PRT), lipids (LIP), and food material (FM), within the sea ice. Samples were collected from the bottom, middle, and top sections of the sea ice column near Cambridge Bay during the spring of 2018. Based on the δ13C signature, biochemical composition, and POC contribution of biopolymeric carbon (BPC), the organic substances within the sea ice were predominantly attributed to marine autotrophs. While the highest concentrations of each parameter were observed at the sea ice bottom, notable concentrations were also found in the upper sections. The average sea ice column-integrated Chl-a concentration was 5.05 ± 2.26 mg m−2, with the bottom ice section contributing 59% (S.D. = ± 10%) to the total integration. The column-integrated concentrations of FM, BPC, POC, and PON were 2.05 ± 0.39, 1.10 ± 0.20, 1.47 ± 0.25, and 0.09 ± 0.03 g m−2, respectively. Contributions of the bottom ice section to these column-integrated concentrations varied for each parameter, with values of 20 ± 6, 21 ± 7, 19 ± 5, and 28 ± 7%, respectively. While the bottom ice section exhibited a substantial Chl-a contribution in line with previous studies, significantly higher contributions of the other parameters were observed in the upper sea ice sections. This suggests that the particulate matter within the interior of the sea ice could potentially serve as an additional food source for higher trophic grazers or act as a seeding material for a phytoplankton bloom during the ice melting season. Our findings highlight the importance of comprehensive field measurements encompassing the entire sea ice section to better understand the distribution of organic carbon pools within the sea ice in the Arctic Ocean.
Prognostic value of diabetes and metformin use in a real-life population of head and neck cancer patients
Authors: De Falco Vincenzo , Vitale Pasquale , Brancati Christian , Cicero Giuseppe , Auriemma Annunziata , Addeo Raffaele 
Published: September 2023

IntroductionHead and neck carcinoma (HNC) is a disease with a poor prognosis despite currently available treatments. The management of patients with this tumor is often complicated by several comorbidities. Among these, diabetes is the second most frequent and its influence on the prognosis is not known.MethodsIn this work, we collected data on progression free survival (PFS) and overall survival (OS) of one hundred twenty-three patients with HNC who received biweekly cetuximab maintenance treatment after first-line chemotherapy. We then compared the survival of nondiabetic patients versus diabetics’ one.ResultsSurprisingly, both PFS (4 vs. 5 months, HR 2.297, p &lt; 0.0001) and OS (7 vs. 10 months, HR 3.138, p &lt; 0.0001) were in favor of diabetic patients, even after excluding other clinical confounding factors. In addition, we also studied survivals in patients taking metformin, a widely used oral antidiabetic drug that has demonstrated antitumor efficacy in some cancers. Indeed, diabetic patients taking metformin had better PFS and OS than those not taking it, 7 vs. 5 months (HR 0.56, p = 0.0187) and 11 vs. 8.5 months (HR 0.53, p = 0.017), respectively.DiscussionIn conclusion, real-world outcomes of biweekly cetuximab maintenance remain comparable to clinical trials. The prognostic role of diabetes and metformin was confirmed to be significant in our series, but further prospective studies are needed for a definitive evaluation.
Gut microbiome association with brain imaging markers, APOE genotype, calcium and vegetable intakes, and obesity in healthy aging adults
Authors: Hammond Tyler C. , Green Stefan J. , Jacobs Yael , Chlipala George E. , Xing Xin , Heil Sally , Chen Anna , Aware Chetan , Flemister Abeoseh , Stromberg Arnold , Balchandani Priti , Lin Ai-Ling 
Published: September 2023

IntroductionAdvanced age is a significant factor in changes to brain physiology and cognitive functions. Recent research has highlighted the critical role of the gut microbiome in modulating brain functions during aging, which can be influenced by various factors such as apolipoprotein E (APOE) genetic variance, body mass index (BMI), diabetes, and dietary intake. However, the associations between the gut microbiome and these factors, as well as brain structural, vascular, and metabolic imaging markers, have not been well explored.MethodsWe recruited 30 community dwelling older adults between age 55-85 in Kentucky. We collected the medical history from the electronic health record as well as the Dietary Screener Questionnaire. We performed APOE genotyping with an oral swab, gut microbiome analysis using metagenomics sequencing, and brain structural, vascular, and metabolic imaging using MRI.ResultsIndividuals with APOE e2 and APOE e4 genotypes had distinct microbiota composition, and higher level of pro-inflammatory microbiota were associated higher BMI and diabetes. In contrast, calcium- and vegetable-rich diets were associated with microbiota that produced short chain fatty acids leading to an anti-inflammatory state. We also found that important gut microbial butyrate producers were correlated with the volume of the thalamus and corpus callosum, which are regions of the brain responsible for relaying and processing information. Additionally, putative proinflammatory species were negatively correlated with GABA production, an inhibitory neurotransmitter. Furthermore, we observed that the relative abundance of bacteria from the family Eggerthellaceae, equol producers, was correlated with white matter integrity in tracts connecting the brain regions related to language, memory, and learning.DiscussionThese findings highlight the importance of gut microbiome association with brain health in aging population and could have important implications aimed at optimizing healthy brain aging through precision prebiotic, probiotic or dietary interventions.