bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended home visits can provide multidimensional adapted professional support for parents – an intervention study
Authors: Larsson Margaretha , Bäckström Caroline , Larsson Rebecca , Gahm Sara , Wilhsson Marie 
Published: July 2023

Abstract

Aim:
The aim of this study was to explore healthcare professionals’ experiences of working with extended home visits for parents.

Background:
It is essential to identify parents, both expectant and with a newborn child, who need support in their parenting abilities at an early stage because children’s health and well-being are affected by their home environment as well as by their parents’ health and social relationships. Home visits represent a cost-effective way of identifying and supporting families with a newborn. Further research is needed to explore healthcare professionals’ experiences working with extended home visits for parents.

Methods:
This was a qualitative interview study focusing on an intervention introduced in the Enhanced Parenting—Extended Home Visits project in Sweden. Data were collected via 13 semi-structured interviews with healthcare professionals who provide the intervention in antenatal care (midwives) and child health care (CHC nurses and family supporters), and a qualitative content analysis was performed.

Findings:
Data analysis resulted in one theme and four categories. The theme – to provide multidimensional adapted professional support, – and the four categories – strengthened collaboration between professionals enriches their work. Home visits provide time for conversation, which promotes continuity of care and relationships with parents; being humble guests in parents’ homes provides insight; and home visits provide the opportunity to strengthen parenting and participation in the family centre. The goals of the Enhanced Parenting—Extended Home Visits project were to strengthen parents’ confidence in their parenting abilities and to build trusting relationships with healthcare professionals. The conclusion of this study, from the participants’ perspective, is that these goals can be achieved with the intervention.

Implications for Practice:
Extended home visits seem to help healthcare professionals provide collaborative, multi-professional support for parents, both expectant and with a newborn child, with unique support needs.
The obligation to prevent environmental harm in relation to armed conflict
Authors: Argren Rigmor 
Published: July 2023

AbstractThe scope of protection of the environment in relation to armed conflict has continued to expand since the issue was first introduced on the international agenda in the 1970s. Today, it is recognized that the environment is a prima facie civilian object and as such it is entitled to the same layers of protection during an armed conflict as any civilian person or object. Thus, there is a legal obligation to prevent environmental harm in armed conflict, before the event. Given the magnitude of environmental damage that can be anticipated in relation to armed conflict, the obligation to prevent such damage in the first place is critical. In this regard, it is important to note that the legal obligation to prevent environmental harm originates from international environmental law. Furthermore, the obligation to prevent harm is an ongoing obligation. This article illustrates that the general preventive obligations found in international environmental law can shed much-needed light on the general preventive obligations already established under the law of armed conflict, in furtherance of environmental protection.
Comparison of Urban Air Quality Simulations During the KORUS‐AQ Campaign With Regionally Refined Versus Global Uniform Grids in the Multi‐Scale Infrastructure for Chemistry and Aerosols (MUSICA) Version 0
Authors: Jo Duseong S. , Emmons Louisa K. , Callaghan Patrick , Tilmes Simone , Woo Jung‐Hun , Kim Younha , Kim Jinseok , Granier Claire , Soulié Antonin , Doumbia Thierno , Darras Sabine , Buchholz Rebecca R. , Simpson Isobel J. , Blake Donald R. , Wisthaler Armin , Schroeder Jason R. , Fried Alan , Kanaya Yugo 
Published: July 2023

AbstractModel intercomparison studies often report a large spread in simulation results, but quantifying the causes of these differences is hindered by the fact that several processes contribute to the model spread simultaneously. Here we use the Multi‐Scale Infrastructure for Chemistry and Aerosols (MUSICA) version 0 to investigate the model resolution dependencies of simulated chemical species, with a focus on the differences between global uniform grid and regional refinement grid simulations with the same modeling framework. We construct two global (ne30 [∼112 km] and ne60 [∼56 km]) and two regional refinement grids over Korea (ne30x8 [∼14 km] and ne30x16 [∼7 km]). The grid resolution can change chemical concentrations by an order of magnitude in the boundary layer, and the importance increases as the species' reactivity increases (e.g., up to 50% and 1,000% changes for ethane and xylenes, respectively). The diurnal cycle of oxidants (OH, O3, and NO3) also varies with the grid resolution, which leads to different oxidation pathways of volatile organic compounds (e.g., the fraction of monoterpenes reacting with NO3 in Seoul around midnight is 90% for ne30, but 65% for ne30x16). The models with high‐resolution grids usually do a better job at reproducing aircraft observations during the KORUS‐AQ campaign, but not always, implying compensating errors in the coarse grid simulations. For example, ozone is better reproduced by the coarse grid due to the artificial mixing of NOx. When developing new chemical mechanisms and evaluating models over urban areas, the uncertainties associated with model resolution should be considered.
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing
Authors: Liu Weijian , Chen Wei , Xie Mao , Chen Chao , Shao Zengwu , Zhang Yiran , Zhao Haiyue , Song Qingcheng , Hu Hongzhi , Xing Xin , Cai Xianyi , Deng Xiangtian , Li Xinyan , Wang Peng , Liu Guohui , Xiong Liming , Lv Xiao , Zhang Yingze 
Published: July 2023

AbstractTraumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains largely unknown. Accumulating evidence indicates that the central nervous system (CNS) plays a pivotal role in regulating immune system and skeletal homeostasis. However, the impact of CNS injury on hematopoiesis commitment was overlooked. Here, we found that the dramatically elevated sympathetic tone accompanied with TBI-accelerated fracture healing; chemical sympathectomy blocks TBI-induced fracture healing. TBI-induced hypersensitivity of adrenergic signaling promotes the proliferation of bone marrow hematopoietic stem cells (HSCs) and swiftly skews HSCs toward anti-inflammation myeloid cells within 14 days, which favor fracture healing. Knockout of β3- or β2-adrenergic receptor (AR) eliminate TBI-mediated anti-inflammation macrophage expansion and TBI-accelerated fracture healing. RNA sequencing of bone marrow cells revealed that Adrb2 and Adrb3 maintain proliferation and commitment of immune cells. Importantly, flow cytometry confirmed that deletion of β2-AR inhibits M2 polarization of macrophages at 7th day and 14th day; and TBI-induced HSCs proliferation was impaired in β3-AR knockout mice. Moreover, β3- and β2-AR agonists synergistically promote infiltration of M2 macrophages in callus and accelerate bone healing process. Thus, we conclude that TBI accelerates bone formation during early stage of fracture healing process by shaping the anti-inflammation environment in the bone marrow. These results implicate that the adrenergic signals could serve as potential targets for fracture management.
Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank
Authors: Watling Cody Z. , Kelly Rebecca K. , Dunneram Yashvee , Knuppel Anika , Piernas Carmen , Schmidt Julie A. , Travis Ruth C. , Key Timothy J. , Perez-Cornago Aurora 
Published: July 2023

Abstract
Background
Evidence concerning intakes of protein or sources of dairy protein and risks of colorectal, breast, and prostate cancers is inconclusive.

Methods
Using a subsample of UK Biobank participants who completed ≥2 (maximum of 5) 24-h dietary assessments, we estimated intakes of total protein, protein from total dairy products, milk, and cheese, and dietary calcium in 114,217 participants. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using multivariable-adjusted Cox regression.

Results
After a median of 9.4 years of follow-up, 1193 colorectal, 2024 female breast, and 2422 prostate cancer cases were identified. There were inverse associations of total dairy protein, protein from milk, and dietary calcium intakes with colorectal cancer incidence (HRQ4 vs Q1:0.80, 95% CI: 0.67–0.94; 0.79, 0.67–0.94; 0.71, 0.58–0.86, respectively). We also observed positive associations of milk protein and dietary calcium with prostate cancer risk (HRQ4 vs Q1:1.12, 1.00–1.26 and 1.16, 1.01–1.33, respectively). No significant associations were observed between intake of dairy protein and breast cancer risk. When insulin-like growth factor-I concentrations measured at recruitment were added to the multivariable-adjusted models, associations remained largely unchanged. Analyses were also similar when looking at total grams of dairy products, milk, and cheese.

Conclusion
Further research is needed to understand the mechanisms underlying the relationships of dairy products with cancer risk and the potential roles of dietary protein and calcium.
Intragenomic rDNA variation - the product of concerted evolution, mutation, or something in between?
Authors: Wang Wencai , Zhang Xianzhi , Garcia Sònia , Leitch Andrew R. , Kovařík Aleš 
Published: July 2023

AbstractThe classical model of concerted evolution states that hundreds to thousands of ribosomal DNA (rDNA) units undergo homogenization, making the multiple copies of the individual units more uniform across the genome than would be expected given mutation frequencies and gene redundancy. While the universality of this over 50-year-old model has been confirmed in a range of organisms, advanced high throughput sequencing techniques have also revealed that rDNA homogenization in many organisms is partial and, in rare cases, even apparently failing. The potential underpinning processes leading to unexpected intragenomic variation have been discussed in a number of studies, but a comprehensive understanding remains to be determined. In this work, we summarize information on variation or polymorphisms in rDNAs across a wide range of taxa amongst animals, fungi, plants, and protists. We discuss the definition and description of concerted evolution and describe whether incomplete concerted evolution of rDNAs predominantly affects coding or non-coding regions of rDNA units and if it leads to the formation of pseudogenes or not. We also discuss the factors contributing to rDNA variation, such as interspecific hybridization, meiotic cycles, rDNA expression status, genome size, and the activity of effector genes involved in genetic recombination, epigenetic modifications, and DNA editing. Finally, we argue that a combination of approaches is needed to target genetic and epigenetic phenomena influencing incomplete concerted evolution, to give a comprehensive understanding of the evolution and functional consequences of intragenomic variation in rDNA.
Operational strategy preventing scaling and wetting in an intermittent membrane distillation process
Authors: Kim Hye-Won , Jang Am , Jeong Seongpil 
Published: July 2023

AbstractThe solar-powered membrane distillation (SPMD) process can improve the energy efficiency by using solar energy as a heat source. However, the SPMD process can only be intermittently operated due to the variation of the daily solar irradiation. In this study, effects of intermittent modes (IMs with/without temperature variations (IM-1/IM-2)) and continuous mode (CM) on scaling and wetting are investigated according to three types of shutdown protocols (P1: non-draining, P2: draining, P3: flushing after draining). A direct contact membrane distillation coupled with a real-time visualization system using the normalized light intensity and SEM-EDS are used for analysis of the MD performance in each condition. Consequently, scaling and wetting tendencies of SPMD at P3 are lowest among the tested shutdown protocols. Furthermore, scaling and wetting in CM and IM (IM-1 and IM-2) at P3 show low differences, indicating that shutdown protocols have a more profound effect than temperature variations and operation mode.
Cultural determinants of the gap between self-estimated navigation ability and wayfinding performance: evidence from 46 countries
Authors: Walkowiak S. , Coutrot A. , Hegarty M. , Velasco P. F. , Wiener J. M. , Dalton R. C. , Hölscher C. , Hornberger M. , Spiers H. J. , Manley E. 
Published: July 2023

AbstractCognitive abilities can vary widely. Some people excel in certain skills, others struggle. However, not all those who describe themselves as gifted are. One possible influence on self-estimates is the surrounding culture. Some cultures may amplify self-assurance and others cultivate humility. Past research has shown that people in different countries can be grouped into a set of consistent cultural clusters with similar values and tendencies, such as attitudes to masculinity or individualism. Here we explored whether such cultural dimensions might relate to the extent to which populations in 46 countries overestimate or underestimate their cognitive abilities in the domain of spatial navigation. Using the Sea Hero Quest navigation test and a large sample (N = 383,187) we found cultural clusters of countries tend to be similar in how they self-rate ability relative to their actual performance. Across the world population sampled, higher self-ratings were associated with better performance. However, at the national level, higher self-ratings as a nation were not associated with better performance as a nation. Germanic and Near East countries were found to be most overconfident in their abilities and Nordic countries to be most under-confident in their abilities. Gender stereotypes may play a role in mediating this pattern, with larger national positive attitudes to male stereotyped roles (Hofstede's masculinity dimension) associated with a greater overconfidence in performance at the national level. We also replicate, with higher precision than prior studies, evidence that older men tend to overestimate their navigation skill more than other groups. These findings give insight into how culture and demographics may impact self-estimates of our abilities.
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
Authors: Lee Donghee , Ryoo Ji Eun , Hong Seungpyo , Kim Hye Yun , Kim YoungSoo 
Published: July 2023

AbstractAlzheimer’s disease (AD) is characterized by misfolding, oligomerization, and accumulation of amyloid-β (Aβ) peptides in the brain. Aβ monomers transform into Aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. The oligomers then deposit into Aβ plaques, primarily composed of β-stranded fibrils, required for definitive AD diagnosis. As amyloid burden plays the pivotal role in AD pathogenesis, many efforts are devoted in preventing amyloidosis as a therapeutic approach to impede the disease progression. Here, we discovered carprofen, a non-steroidal anti-inflammatory drug, accelerates Aβ aggregating into fibrils and increases Aβ plaques when intraperitoneally injected to 5XFAD transgenic mouse model. However, the drug seems to alleviate the key Alzheimer-like phenotypes induced by Aβ aggregation as we found attenuated neuroinflammation, improved post-synaptic density expression, associated with synaptic plasticity, and decreased phosphorylated tau levels. Carprofen also rescued impaired working memory as we discovered improved spontaneous alternation performance through Y-maze test assessed with Aβ(1–42)-infused mouse model. Collectively, while carprofen accelerates the conversion of Aβ monomers into fibrils in vitro, the drug ameliorates the major pathological hallmarks of AD in vivo.
Evaluating clinical diversity and plausibility of synthetic capsule endoscopic images
Authors: Vats Anuja , Pedersen Marius , Mohammed Ahmed , Hovde Øistein 
Published: July 2023

AbstractWireless Capsule Endoscopy (WCE) is being increasingly used as an alternative imaging modality for complete and non-invasive screening of the gastrointestinal tract. Although this is advantageous in reducing unnecessary hospital admissions, it also demands that a WCE diagnostic protocol be in place so larger populations can be effectively screened. This calls for training and education protocols attuned specifically to this modality. Like training in other modalities such as traditional endoscopy, CT, MRI, etc., a WCE training protocol would require an atlas comprising of a large corpora of images that show vivid descriptions of pathologies, ideally observed over a period of time. Since such comprehensive atlases are presently lacking in WCE, in this work, we propose a deep learning method for utilizing already available studies across different institutions for the creation of a realistic WCE atlas using StyleGAN. We identify clinically relevant attributes in WCE such that synthetic images can be generated with selected attributes on cue. Beyond this, we also simulate several disease progression scenarios. The generated images are evaluated for realism and plausibility through three subjective online experiments with the participation of eight gastroenterology experts from three geographical locations and a variety of years of experience. The results from the experiments indicate that the images are highly realistic and the disease scenarios plausible. The images comprising the atlas are available publicly for use in training applications as well as supplementing real datasets for deep learning.
Tribocatalytically-active nickel/cobalt phosphorous films for universal protection in a hydrocarbon-rich environment
Authors: Shirani Asghar , Al Sulaimi Rawan , Macknojia Ali Zayaan , Eskandari Mohammad , Berman Diana 
Published: July 2023

AbstractHigh-contact stresses generated at the sliding interfaces during their relative movement provide a unique combination of local heating and shear- and load-induced compression conditions. These conditions, when involving the sliding of surfaces with certain material characteristics, may facilitate tribochemical reactions with the environment, leading to the formation of a protective, damage-suppressing tribofilm directly at the contact. Here, we employ the electrodeposition process to design a coating composed of a hard cobalt-phosphorous matrix with the inclusion of tribocatalytically-active nickel clusters. The coating is optimized in terms of its relative composition and mechanical characteristics. We demonstrate the excellent tribological performance of the coating in the presence of a hydrocarbon environment, both in the form of a liquid lubricant and as a hydrocarbon-saturated vapor. Characterization of the wear track indicates that the origin of such performance lies in the formation of a protective carbon-based tribofilm on the surface of the coating during sliding. These results contribute to the advancement of knowledge on material transformations in the contact, thus providing a robust and versatile approach to addressing tribological challenges in mechanical systems.
Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
Authors: Nishigori Naomi , Muraoka Yuki , Ishikura Masaharu , Kogo Takahiro , Ueda-Arakawa Naoko , Miyata Manabu , Tamura Hiroshi , Hata Masayuki , Takahashi Ayako , Miyake Masahiro , Tsujikawa Akitaka 
Published: July 2023

AbstractWe examined the effect of reduced fluence (rf)-photodynamic therapy (PDT) of the macular area on the wide-field choroidal thickness in 20 eyes with central serous chorioretinopathy (CSC) and 20 age- and sex-matched control eyes. The choroidal thickness at the posterior pole was measured before and after rf-PDT, using a grid with inner and outer rings, each divided into superotemporal, inferotemporal, superonasal, and inferonasal quadrants, respectively, making up a total of nine subfields including the central 3 mm ring. Before treatment, all eyes showed wide-field choroidal thickening from the dilated vortex vein ampulla to the fovea, along the course of the vein. After rf-PDT of the macular area, the choroidal thickness significantly decreased, not only in the irradiated macular area but also outside the arcade vessels in all quadrants (p < 0.001 for all inner subfields; p = 0.035 and p = 0.024 for the outer superonasal and inferonasal subfields, respectively; p < 0.001 and p = 0.004 for the outer superotemporal and inferotemporal subfields, respectively). For control eyes, the choroidal thickness did not differ between the initial visit and follow-up 1.2 ± 0.7 months after the initial visit (p > 0.05 for all subfields). These findings provide new insights into the pathogenesis of CSC and explain the reasons for the effectiveness of rf-PDT for this condition.
Enhancing post-thaw quality of ram epididymal sperm by supplementation of rutin in cryopreservation extender
Authors: Najafi Abouzar , Mohammadi Hossein , Sharifi Seyed Davood 
Published: July 2023

AbstractThe purpose of this study was to examine the effect of different rutin concentrations on rams epididymal sperm. A local slaughterhouse provided 50 pair of testes from 25 rams. The testes were sent to the lab at room temperature. Spermatozoa were extracted by suspending portions of cauda epididymis in tris solution. Ram sperm was cryopreserved (in liquid nitrogen) in a tris extender containing rutin at 0, 0.5, 0.75, 1, and 1.25 mM. Rutin showed superior sperm total and progressive motility, beat cross frequency, straight line velocity, velocity average pathway and membrane integrity values at 0.75 and 1 mM. The morphology of the sperm and the superoxide dismutase levels did not significantly change with different treatments. Moreover, rutin at 0.75 and 1 mM was also shown to have the highest level of mitochondrial activity. The results showed ATP, total antioxidant capacity, and glutathione peroxidase levels were significantly greater in the rutin 0.75 and 1 mM groups (P < 0.05). Rutin at 0.75 and 1 mM levels had the lowest reactive oxygen species concentrations. Rutin at 0.75 and 1 mM substantially increased the proportion of viable sperm (P < 0.05). The lowest amount of apoptosis was observed in 0.75 and 1 mM rutin. Rutin at 0.75 and 1 mM yielded the least significant percentage of dead sperm. It may be inferred that adding 0.75 and 1 mM to the sperm extender can enhance the quality of the epididymal sperm in rams after the cryopreservation process.