bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Appendicitis as the First and the Only Presentation of Systemic Mastocytosis
Authors: Sarwate Mrinal , Bakhshwin Ahmed 
Published: July 2023

ABSTRACT
Systemic mastocytosis is a rare myeloproliferative disorder characterized by abnormal accumulation of mast cells in a variety of organs. When affecting the gastrointestinal tracts, it may manifest with steatorrhea, malabsorption, hepatomegaly, splenomegaly, portal hypertension, and ascites, among others. To our knowledge, only one case of systemic mastocytosis has been reported affecting the appendix. We present another case of a 47-year-old woman who was admitted for right-sided acute abdominal pain and found to have systemic mastocytosis in her appendectomy specimen as the first and only manifestation of her disease.
Existence of nonminimal solutions to an inhomogeneous elliptic equation with supercritical nonlinearity
Authors: Ishige Kazuhiro , Okabe Shinya , Sato Tokushi 
Published: July 2023

Abstract
In our previous paper [K. Ishige, S. Okabe, and T. Sato, A supercritical scalar field equation with a forcing term, J. Math. Pures Appl. 128 (2019), pp. 183–212], we proved the existence of a threshold

κ

∗

>
0

{\kappa }^{\ast }\gt 0

such that the elliptic problem for an inhomogeneous elliptic equation

−
Δ
u
+
u
=

u

p

+
κ
μ

-\Delta u+u={u}^{p}+\kappa \mu

in

R

N

{{\bf{R}}}^{N}

possesses a positive minimal solution decaying at the space infinity if and only if

0
<
κ
≤

κ

∗

0\lt \kappa \le {\kappa }^{\ast }

. Here,

N
≥
2

N\ge 2

,

μ

\mu

is a nontrivial nonnegative Radon measure in

R

N

{{\bf{R}}}^{N}

with a compact support, and

p
>
1

p\gt 1

is in the Joseph-Lundgren subcritical case. In this article, we prove the existence of nonminimal positive solutions to the elliptic problem. Our arguments are also applicable to inhomogeneous semilinear elliptic equations with exponential nonlinearity.
Cloning and expression analysis of VrNAC13 gene in mung bean
Authors: Zhang Siyu , Ai Jing , Guo Yaning , Bai Yu , Yao Han , Wang Fugang 
Published: July 2023

Abstract
To explore the role of NAC transcription factors in mung bean (Vigna ratiata), we here comprehensively analyzed VrNAC13 structure and expression patterns in the mung bean cultivar “Yulin No.1”. The nucleotide sequence of VrNAC13 (GenBank accession number xp014518431.1) was determined by cloning and sequencing the gene. A predicted transcriptional activation domain in VrNAC13 was validated with a yeast one-hybrid assay. The composition and functional characteristics of VrNAC13 were analyzed using basic bioinformatics techniques, and the expression characteristics of VrNAC13 were analyzed via quantitative reverse transcription-PCR. The results showed that VrNAC13 was 1,068 bp in length and encoded a product of 355 amino acids. VrNAC13 was predicted to contain a NAM domain and to belong to the NAC transcription factor family. The protein was hydrophilic and contained several threonine phosphorylation sites. Phylogenetic analysis showed that VrNAC13 was highly similar in sequence to two Arabidopsis thaliana NAC proteins; we hypothesize that VrNAC13 may perform functions in mung bean similar to those of the two closely related proteins in Arabidopsis. Promoter analysis of VrNAC13 revealed cis-acting elements predicted to respond to abscisic acid (ABA), gibberellin, auxin, light, drought, low temperature, and other stressors. VrNAC13 was most highly expressed in the leaves and expressed at very low levels in the stem and root. It was experimentally determined to be induced by drought and ABA. Based on these results, VrNAC13 appears to regulate stress resistance in mung bean.
Investigation of MXene-modified agar/polyurethane hydrogel elastomeric repair materials with tunable water absorption
Authors: Liu Jinbo , Tang Xuewei , Chen Xiaotong , Wang Guoqing 
Published: July 2023

Abstract
The study of repairing materials is of paramount importance, considering that damage during usage can significantly impact performance and bring inconvenience during maintenance work. One highly sought-after material is water-swellable elastomers, known for their effect in sealing and repairing damaged materials. In this study, agar/polyurethane dual-network hydrogel elastomers were prepared, which were further modified by MXene. The material exhibits a uniform and flat surface, along with a rich pore-filled internal structure. It showcases excellent thermal stability, good tensile strength retention, and a controllable low swelling rate (SR) upon water absorption. The performance of the material can be regulated by the MXene content. In addition, the “water absorption–drying–water absorption” cycle effectively controls the reduction of the SR and gradually increases the tensile strength. All samples demonstrated exceptional photothermal conversion efficiency, stability, and durability, with the maximum conversion temperature increasing with the MXene content. The scratch repair experiments demonstrated the remarkable potential of these materials for photothermal conversion-assisted repair. These materials can be adapted as auxiliary restoration materials in water bodies and various application environments, making them ideal for repair and restoration purposes.
Space use by Callosciurus erythraeus in a fragmented landscape
Authors: Guichón M. Laura , Benitez Verónica V. , Gozzi A. Cecilia , Doyle Santiago R. , Cassini Guillermo H. 
Published: July 2023

Abstract
Tree squirrel species that are successful invaders may modify their behaviour according to the characteristics of the invaded community. We studied the use of space by Callosciurus erythraeus in the main invasion focus established in Argentina, where suitable habitat is highly fragmented and immersed in a rural–urban landscape of the Pampas region. We evaluated habitat use in relation to the dominant arboreal vegetation (evergreen vs. deciduous) based on seasonal trapping data throughout two years and home range size and overlap based on seasonal radio-tracking data in two consecutive years. We captured 476 squirrels with a higher trapping success in areas dominated by evergreen vegetation. Effective home ranges were smaller for females (0.10–0.77 ha, n = 12) than for males (0.9–3.78 ha, n = 3). We observed home range overlap between and within both sexes, suggesting no or low territoriality. Our results support the two working hypotheses on the relatively higher use of areas dominated by evergreen vegetation and on the relatively small home range sizes and large overlapping areas associated to high squirrel density. The flexibility in the use of different type of arboreal patches would be another attribute linked to the invasion success of this species.
Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
Authors: Wu Weichu , Zhang Yonghai , Liu Guoyuan , Chi Zepai , Zhang Aiping , Miao Shuying , Lin Chengchuang , Xu Qingchun , Zhang Yuanfeng 
Published: July 2023

Abstract
Corona virus disease 2019 (COVID-19) is prone to induce multiple organ damage. The kidney is one of the target organs of SARS-CoV-2, which is susceptible to inducing acute kidney injury (AKI). Huanglian Jiedu Decoction (HLJDD) is one of the recommended prescriptions for COVID-19 with severe complications. We used network pharmacology and molecular docking to explore the therapeutic and protective effects of HLJDD on COVID-19-associated AKI. Potential targets related to “HLJDD,” “COVID-19,” and “Acute Kidney Injury/Acute Renal Failure” were identified from several databases. A protein–protein interaction (PPI) network was constructed and screened the core targets according to the degree value. The target genes were then enriched using gene ontology and Kyoto Encyclopedia of Genes and Genomes. The bioactive components were docked with the core targets. A total of 65 active compounds, 85 common targets for diseases and drugs were obtained; PPI network analysis showed that the core protein mainly involved JUN, RELA, and AKT1; functional analysis showed that these target genes were mainly involved in lipid and atherosclerosis signaling pathway and IL-17 signal pathway. The results of molecular docking showed that JUN, RELA, and AKT1 had good binding activity with the effective chemical components of HLJDD. In conclusion, HLJDD can be used as a potential therapeutic drug for COVID-19-associated AKI.
Crack Initiation in Bulk Matrix of Austenitic Stainless Steel during Very High Cycle Fatigue
Authors: Chai Guocai , Bergström Jens , Burman Christer 
Published: July 2023

Abstract
In the very high cycle fatigue regime, fatigue crack initiation in high-strength steels is usually correlated to a subsurface inclusion with a fine granular area (FGA). Localized stress–strain concentration at the subsurface inclusion is a critical factor. Fatigue crack initiation with an FGA in the bulk matrix without any defect has rarely been reported. In this paper, a fundamental study on the formation of FGAs in the bulk matrix of an austenitic stainless steel has been carried out using a progressive stepwise load-increasing test with a cycle step of about 108 cycles. FGA formation in the subsurface bulk matrix has been observed. The microstructural damage in the fatigue-tested specimens has been studied using the electron channeling contrast imaging electron microscopy technique. Strain localization and grain fragmentation are the main processes for the formation of FGAs. Local plasticity exhaustion leads to crack initiation due to local stress concentrations. This method can also be used to predict the fatigue damage process, especially the damage rate in individual specimens.
OS PRINCÍPIOS FUNDADORES DO PENSAMENTO BENVENISTIANO E A ABERTURA PARA ANÁLISE NA LITERATURA
Authors: Da Silva André Rodrigues , Neumann Daiane 
Published: July 2023

O objetivo deste artigo é buscar os princípios fundadores da teorização benvenistiana, especificamente a partir do estudo dos pronomes e da subjetividade, a fim de atentar para o fato de que a construção desses princípios teóricos potencializa a interface entre língua e literatura, para uma abertura de análise em obras literárias. Será feita, com isso, uma discussão acerca da língua e linguagem, através da consideração sobretudo dos textos que compõem a quinta parte dos Problemas de Linguística Geral I intitulado “O homem na língua”. Ademais, é de nosso interesse refletir acerca de como essa reflexão teórica advinda do pensamento benvenistiano foi explorada por diferentes pesquisas que buscam a interface aqui propulsionada, no contexto francês e no brasileiro.
Distinct Frontoparietal Brain Dynamics Underlying the Co-Occurrence of Autism and ADHD
Authors: Watanabe Daichi , Watanabe Takamitsu 
Published: July 2023

AbstractPrevious diagnostic systems precluded the co-existence of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in one person; but, after many clinical reports, the diagnostic criteria were updated to allow their co-occurrence. Despite such a clinical change, the neurobiological bases underpinning the comorbidity remain poorly understood, and whether the ASD+ADHD condition is a simple overlap of the two disorders is unknown. Here, to answer this question, we compared the brain dynamics of high-functioning ASD+ADHD children with age-/sex-/IQ-matched pure ASD, pure ADHD, and typically developing (TD) children. Regarding autistic traits, the socio-communicational symptom of the ASD+ADHD children was explained by the same overstable brain dynamics as seen in pure ASD. In contrast, their ADHD-like traits were grounded on a unique neural mechanism that was unseen in pure ADHD: the core symptoms of pure ADHD were associated with the overly flexible whole-brain dynamics that were triggered by the unstable activity of the dorsal-attention network and the left parietal cortex; by contrast, the ADHD-like cognitive instability of the ASD+ADHD condition was correlated with the atypically frequent neural transition along a specific brain state pathway, which was induced by the atypically unstable activity of the frontoparietal control network and the left prefrontal cortex. These observations need to be validated in future studies using more direct and comprehensive behavioral indices, but the current findings suggest that the ASD+ADHD comorbidity is not a mere overlap of the two disorders. Particularly, its ADHD-like traits could represent a unique condition that would need a specific diagnosis and bespoke treatments.
Differential Modulation of GABAergic and Glutamatergic Neurons in the Ventral Pallidum by GABA and Neuropeptides
Authors: Neuhofer Daniela , Kalivas Peter 
Published: July 2023

AbstractThe ventral pallidum (VP) is an integral locus in the reward circuitry and a major target of GABAergic innervation of both D1-medium spiny neurons (MSNs) and D2-MSNs from the nucleus accumbens. The VP contains populations of GABAergic [VPGABA, GAD2(+), or VGluT(–)] and glutamatergic [VPGlutamate, GAD2(–), or VGluT(+)] cells that facilitate positive reinforcement and behavioral avoidance, respectively. MSN efferents to the VP exert opponent control over behavioral reinforcement with activation of D1-MSN afferents promoting and D2-MSN afferents inhibiting reward seeking. How this afferent-specific and cell type-specific control of reward seeking is integrated remains largely unknown. In addition to GABA, D1-MSNs corelease substance P to stimulate neurokinin 1 receptors (NK1Rs) and D2-MSNs corelease enkephalin to activate μ-opioid receptors (MORs) and δ-opioid receptors. These neuropeptides act in the VP to alter appetitive behavior and reward seeking. Using a combination of optogenetics and patch-clamp electrophysiology in mice, we found that GAD2(–) cells receive weaker GABA input from D1-MSN, but GAD2(+) cells receive comparable GABAergic input from both afferent types. Pharmacological activation of MORs induced an equally strong presynaptic inhibition of GABA and glutamate transmission on both cell types. Interestingly, MOR activation hyperpolarized VPGABA but not VGluT(+). NK1R activation inhibited glutamatergic transmission only on VGluT(+) cells. Our results indicate that the afferent-specific release of GABA and neuropeptides from D1-MSNs and D2-MSNs can differentially influence VP neuronal subtypes.
The Determinants Of Economic Growth In North African Countries
Authors: Imleesh Mohammed Mahmoud 
Published: July 2023

Economic growth is one of the most important indicators used in developing and evaluating the economic activity of developing countries, including North African countries, but economic growth faces several major economic challenges such as FDI, unemployment rate, inflation and exchange rate. This study used quantitative research, and data were collected by documentation method with secondary data since 2001-2020, Based on the results of the analysis by panel data regression, it was found that FDI is statistically significant, while it has a positive sign, which indicates that it has a positive impact on economic growth, If FDI increase by1%, economic growth will increase by 0.684%, and there is no impact of inflation and unemployment rate on economic growth, and the exchange rate has a positive and significant impact on economic growth, as each increase leads by 1% in the exchange rate to a increase in economic growth by 0.420%, in future research other variables affecting economic growth, such as the volume of exports, import tariffs, taxes or government regulations.
Investigation of the effects of some wall materials and encapsulation techniques on the microencapsulation of olive leaf extract
Authors: Kahraman S. , Demircan H. , Sarioglu K. , Demircan S. , Oral R.A. 
Published: July 2023

AbstractIn this study, it is aimed to encapsulate some functional components of the olive leaves. Olive leaf extract was encapsulated using solution of sodium alginate, sodium alginate/gelatine, and sodium alginate/agar as wall material by ionic gelation technique. Also, olive leaf extract was encapsulated using solution of gelatine as wall material by cold gelation technique. The viscosities of the coating materials used in the study were investigated. An optimisation process was carried out to determine the injection time to be applied in the ionic gelation technique and the encapsulation efficiencies, particle sizes, swelling ratios, in vitro release profiles, and antioxidant activities of the obtained capsules were determined. While the encapsulation efficiency of the capsules obtained by the cold gelation technique was determined as the highest (98.2 ± 0.99%), it was revealed that the viscosity of the wall material used in the ionic gelation technique was important in the encapsulation efficiency. The particle size and swelling rate of the capsules obtained using the cold gelation technique were the highest. The release rate of oleuropein was generally higher at gastric pH than at intestinal pH. A correlation was found between antioxidant activities and the encapsulation efficiency of capsules.
Penerapan model discovery learning untuk meningkatkan kemampuan berpikir analitis siswa pada mata pelajaran Geografi di SMAN 1 Kademangan
Authors: Cahya Rinanda Dwi , Suharto Yusuf , Insani Nailul 
Published: July 2023

This study aims to improve analytical thinking skills in geography subjects in class XI IPS 2 SMAN 1 Kademangan Blitar using the Discovery Learning learning. This research is a Class Action Research. This type of research aims to overcome problems that are in the classroom that have been observed before. The students targeted by the study were in class XI IPS 2 with the number of students, namely 34 students, with the number of men 11 and women 23 students. Data collection techniques use primary data obtained from the implementation of actions. Research instruments used in the form of test questions and field records. The data analysis used is to compare the average score of students' analytical thinking skills The average result of the analytical thinking skills test score in cycle I was 64 while in cycle II it was 83 so that it increased the score by 19 with a percentage of 29.6875%. Conclusions from the results of the study reveal that the application of Discovery Learning can improve students' analytical thinking skills.
Tujuan dari penelitian ini untuk meningkatkan kemampuan berpikir analitis pada mata pelajaran geografi di kelas XI IPS 2 SMAN 1 Kademangan Blitar dengan menggunakan model pembelajaran Discovery Learning. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Jenis penelitian ini yang bertujuan untuk mengatasi masalah yang berada di dalam kelas yang sudah di observasi sebelumnya. Siswa yang menjadi sasaran penelitian berada di kelas XI IPS 2 dengan jumlah siswa yaitu 34 siswa, dengan jumlah laki-laki 11 dan perempuan 23 siswa. Teknik pengumpulan data menggunakan data primer yang diperoleh dari pelaksanaan tindakan. Instrumen penelitian yang digunakan berupa soal tes dan catatan lapangan. Analisis data yang digunakan adalah dengan membandingkan skor rata-rata kemampuan berpikir analitis siswa. Hasil rata-rata skor tes kemampuan berpikir analitis pada siklus I adalah 64 sedangkan pada siklus II yaitu 83 sehingga mengalami peningkatan skor sebesar 19 dengan presentase 29.6875%. Kesimpulan dari hasil penelitian mengungkapkan bahwa penerapan Discovery Learning dapat meningkatkan kemampuan berpikir analitis siswa.
The economic limit on sporting success: how can football industry develop?
Authors: Platonov V. V. , Kuziaev D. A. 
Published: July 2023

Purpose: of the article is to develop recommendations for the development of football enterprises based on the study of the economic causes of the phenomenon of "overeinvestment" in the football industry.Methods: regression based on the Cobb-Douglas production function with data from the Russian Tax Service database as well as data of the Russian premier league (RPL) for 2018–2022. Results: football industry suffers extreme diseconomies of scale in persuade for sporting success unlike the most other industries. Success in RPL statistically significantly determined not only by labor costs but as well as by capital costs. At the same time, the elasticity of the league outcome to labor costs is somewhat lower than that of capital costs. By getting higher league standing by boosting costs a team enters on plateau of vanishing sporting gains. The predicted dependence of the performance in RPL based on costs pattern is very close to the actual data, including the economic limit of the maximum league outcome. Alongside the labor costs, other tangible and intangible factors are significant, especially for clubs with sustainable competitive advantage and better ability to sustain diseconomies of scale.Conclusions and Relevance: the root cause of overinvestment in football industry is the extreme diseconomies of scale, with other factors being consequences. The development of the industry is possible by combination of sporting and business performance by producing entertainment and information products. Sustainable advantage requires the development of intellectual capital, which improves returns and resilience to rising costs. It requires innovation to develop resources and capabilities of the football enterprise e.g. network capital and organizational know-how.
Entrepreneurship Orientation to Nurture the Halal Food Industry Future in Ethiopia
Authors: Fikadu Gemechis , Kebede Kenesa , Kant Shashi 
Published: July 2023

The concept of entrepreneurship is not unique in Islam, as observed from history, that the Prophet and His disciples engaged in it as a respectable profession. Islamic economic academics recently invented the term "Halal entrepreneurship" or "Halalpreneurship" to describe and separate business owners in the Halal market from those in other industries. Islamic ideas are incorporated into business owners in the Halal sector, reshaping them through certain traits that permit the usage of the phrases "Halalpreneurs" and "Halalpreneurship." But defining Halalpreneurship has only been addressed in a few number of scholarly papers. In this sense, this chapter aims to achieve two main objectives. To properly introduce Halal entrepreneurship (Halalpreneurship), it is first necessary to highlight the salient features that distinguish it from other forms of business. Researchers assessed RMSEA levels under 0.05 to be good, between 0.05 and 0.08 to be acceptable, between 0.08 and 0.1 to be marginal, and over 0.1 to be poor, all in accordance with some theoretical underpinnings. Here, all latent item covariance was greater than 0.70, indicating a good match. One will be able to recognize their position as a Halalpreneur in the Halal industry with the help of such understanding and knowledge. The impact of exposure on the outcome is the direct effect in the absence of the mediator. The effect of exposure on the outcome of mediation is the working indirect pathway.