bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PHYSICAL ACTIVITY BERBASIS HEALTH BELIEF MODEL DENGAN SIKAP DALAM MENGONTROL KADAR GULA DARAH PADA PASIEN DIABETES MELLITUS TIPE 2 DI KABUPATEN TAKALAR
Authors: Zainuddin Zainuddin , Ernawati Ernawati , Sulistiani Ita , Jamaludin Nurdiana , Meylandri Arsad Sitti Fatimah , Suardi Suardi , Wahyudin Wahyudin 
Published: January 2025

Latar belakang: Diabetes mellitus tipe 2 (DMT2) adalah penyakit gangguan metabolik yang di tandai oleh kenaikan gula darah akibat penurunan sekresi insulin oleh sel beta pankreas dan atau gangguan fungsi insulin (resistensi insulin). Tujuan penelitian: Penelitian ini bertujuan untuk mengetahui hubungan physical activity berbasis health belief model dengan sikap dalam mengontrol kadar gula darah pada pasien DMT2 di wilayah kerja Puskesmas Polongbangkeng Utara Kabupaten Takalar. Metode penelitian: Desain penelitian yang di gunakan deskriptif analitik dengan pendekatan cross-sectional studi. Dengan jumlah sampel sebanyak 50 responden. Dengan tehnik pengambilan sampel purposive sampling. Hasil penelitian: Hasil analisis bivariat menunjukkan bahwa uji fisher’s exact test di peroleh nilai hitung p=0,000 lebih kecil dari nilai α=0,05. Dari analisis tersebut dapat di artikan bahwa Ha diterima dan Ho di tolak. Kesimpulan: ada hubungan physical activity berbasis health belief model dengan sikap dalam mengontrol kadar gula darah pada pasien diabetes mellitus tipe 2 di Kabupaten Takalar 2023.
Outpatient Management of a Pediatric Morel-Lavallée Lesion
Authors: Rapole Sanika , Gandhi Tejas , Sodhai Vivek , Patwardhan Sandeep , Sancheti Parag 
Published: January 2025

Case:
Pediatric Morel-Lavallée lesions are infrequent and may present in atypical locations. A 3-year-old boy presented with a nontender, mobile, cystic swelling on the medial aspect of his left distal thigh, 2 weeks after a road traffic accident. The diagnosis was confirmed using 3D ultrasonography. The lesion was treated with percutaneous aspiration and drainage without anesthesia, followed by an elastic compression bandage on an outpatient basis. Subsequent follow-up showed no recurrence, and the patient achieved full functional status within 4 weeks and was asymptomatic at 1-year follow-up.

Conclusion:
Percutaneous aspiration and drainage without anesthesia is a safe and effective outpatient treatment for children without fractures.
Closed Management of a Bent Tibial Nail: Can Revision Be Avoided?
Authors: Mousley Johanna J. , Kjar Richard , Reidy Michael , Lambers Anton 
Published: January 2025

Case:
A 49-year-old gentleman sustained a closed, right tibia peri-implant fracture with a bent intramedullary nail. This resulted in a 17° valgus and 5° recurvatum deformity with fracture at the distal third of the tibial shaft. The patient underwent closed manipulation with an F-Tool and was reviewed by our unit over the following year.

Conclusion:
This is the first case report of closed manipulation of a tibial fracture over a bent implant. This approach was successful in correcting deformity to within acceptable limits, achieved radiological union, and was associated with excellent patient-reported outcomes at all points of follow-up.
Sternoclavicular Joint Reconstruction Using a Hamstring and Cadaveric Fibular Cortical Allograft
Authors: Gaetano Andrew , Boubekri Amir , Chen Andrew , Garbis Nickolas , Salazar Dane 
Published: January 2025

Case:
A 49-year-old woman with sternoclavicular insufficiency following medial clavicle resection underwent sternoclavicular joint reconstruction using a hamstring allograft and a cadaveric fibular cortical allograft. After 4 months of follow-up, the patient was pain-free, with radiographic evidence of graft incorporation by 8 months.

Conclusion:
Medial clavicle resection is a rare procedure with broad indications. The necessity and optimal technique for subsequent sternoclavicular reconstruction remain debated. We demonstrate a figure-of-eight reconstructive technique that may provide acceptable clinical results when addressing large medial clavicle defects.

Level of Evidence:
IV.
Triple Pelvic Osteotomy Provides Joint Stability and Acetabular Bone Stock Following Hip Hemiarthroplasty for Ewing Sarcoma
Authors: Breulmann Franziska Lioba , Andronic Octavian , Müller Daniel , Canonica Sandro , Nieuwland Arend , Dreher Thomas 
Published: January 2025

Case:
Triple pelvic osteotomy (TPO) is used to treat developmental dysplasia of the hip in a pediatric population. This case report highlights a new indication for this procedure. Acetabular coverage was restored in a 9-year-old patient who experienced instability following hip hemiarthroplasty and proximal femur composite allograft implantation for the treatment of Ewing sarcoma.

Conclusion:
TPO can be used to treat instability following prosthetic hip replacement in pediatric patients with open triradiate cartilage. It restores the acetabular bone stock and should facilitate future acetabular component implantation or revisions.
Detection of Multiple Tibial Malalignment-Induced Early Polyethylene Breakage Using Single Plane Fluoroscopy
Authors: Sugimoto Atsushi , Ishibashi Teruya , Yamazaki Takaharu , Tamaki Masashi , Okada Seiji , Tomita Tetsuya 
Published: January 2025

Case:
A 75-year-old woman underwent cruciate retaining total knee arthroplasty (TKA) for osteonecrosis of the knee, converted from unicompartmental arthroplasty due to an intraoperative medial tibial plateau fracture. Four years later, she experienced persistent knee pain. Computed tomography revealed tibial malalignments in 2 planes. In vivo kinematic analysis using single-plane fluoroscopy, which can visualize the femorotibial contact, indicated varus thrust with lateral subluxation of the tibial component and the femoral component recessing into the polyethylene insert. Revision TKA affirmed the polyethylene insert breakage.

Conclusion:
Malalignment might have caused mechanical failure, and in vivo kinematic analysis was useful to visualize abnormal kinematics in TKA.
REKONSTRUKSI JARINGAN KOMPUTER DENGAN METODE TOP-DOWN (STUDI KASUS SMKN 3 BANGKALAN)
Authors: Tahir Muhlis , Aini Nuru , Cahyani Laili , Yuni Wijaya Etistika , Afif Effindi Muhamad , Dellia Prita 
Published: January 2025

Jaringan komputer terdiri dari dua atau lebih perangkat komputasi yang saling berhubungan atau terhubung dan digunakan untuk sumber data yang berbeda.. SMK Negeri 3 Bangkalan selama ini tekah memiliki rangkaian jaringan LAN yang sudah dan telah menerapkan sistem teknologi komputer pada beberapa aktivitas di lingkungan sekolah, sehingga kondisi jaringan komputer yang ada di sekolah tersebut dalam kondisi baik, cepat dan aman namun seiring berjalannya waktu rangkaian jaringan LAN yang terbentuk dengan mulai mengalami gangguan pada kabel koneksi jaringan, SMKN 3 Bangkalan yang mungkin mengalami masalah pada kinerja jaringan karena komputer. Metode top-down banyak digunakan untuk pengembangan jaringan, dan metode top-down itu sendiri adalah metode untuk membangun jaringan area lokal di mana setiap unit dibangun pada waktu yang sama. Hasil analisis perbandingan PING pada IP awal dengan IP tujuan diketahui dalam kondisi jaringan existing mendapatkan nilai waktu PING 1072 ms dan average 52. 48 ms untuk TTL yang didapatkan dengan nilai waktu 28421 ms dan average 1561.86 ms, sedangkan pada kondisi jaringan yang diusulkan mendapatkan nilai waktu PING 59 ms dan average 2.7776 ms untuk TTL yang didapatkan dengan nilai waktu 27741 ms dan average 1566.67 ms, dapat disimpulkan pada kondisi jaringan yang di usulkan untuk nilai waktu PING lebih baik dari kondisi existing. Dengan menggunakan metode ini, diharapkan dapat membuat jaringan baru dengan fungsionalitas yang lebih baik.Kata kunci: Jaringan Komputer, SMKN 3 Bangkalan , Top Down
Transient, Turbulent Hall Currents in the Sunlit Terrestrial Ionosphere
Authors: Ivarsen Magnus , Huyghebaert Devin , Jin Yaqi , Miyashita Yukinaga , St.-Maurice Jean-Pierre , Hussey Glenn , Dan Billett , Kasahara Satoshi , Song Kaili , Jayachandran P , Yokota Shoichiro , Miyoshi Yoshizumi , Kasahara Yoshiya , Shinohara Iku , Matsuoka Ayako 
Published: January 2025

Abstract

At night in Earth's polar regions, energetic aurorae frequently penetrate into the atmosphere, driving turbulent electrojet currents in the bottomside ionosphere. During the day, however, Earth's plasma environment become highly conductive, caused by the constant extreme ultraviolet radiation emitted from the Sun. The high-conductivityplasma in the dayside ionosphere can effectively short out plasma turbulence around aurorae, and so electrojet turbulence is rare in the dayside high-latitude ionosphere. In this report, we show observations to the contrary. During the onset of the 23 April 2023 geomagnetic storm, we observe prolific small-scale plasma turbulence in the dayside E-region on closed magnetic field-lines just equatorward of the cusp. Using data from two orbiting satellites, we infer the location of the cusp and the widespread presence of diffuse aurorae, through observations of particle precipitation and wave-particle interactions near the magnetospheric equator. The diffuse aurorae pass electric fields and produce unstable gradients in the plasma density. The number and intensity of the falling charges overwhelm the capacity of the lower ionosphere to neutralize the charges, spurring the growth of turbulent electrojets. We thereby establish correlation and causality between observations of chorus wave activity near the magnetospheric equator and observations of turbulent electrojets in the ionosphere on closed magnetic field-lines. We discuss the implications that this discovery bears for the electrodynamics of the dayside ionosphere.
Understanding hospital activity and outcomes for people with multimorbidity using electronic health records
Authors: Anand Atul , Georgiev Konstantin , McPeake Joanne , Shenkin Susan , Fleuriot Jacques , Lone Nazir , Guthrie Bruce , Jacko Julie 
Published: January 2025

Abstract

Background
As the prevalence of multimorbidity grows, provision of effective healthcare is more challenging. Both multimorbidity and complexity in delivery of healthcare may be associated with worse outcomes.
Methods
We studied consecutive, unique emergency non-surgical hospitalisations for patients over 50 years old to three hospitals in Scotland, UK between 2016 and 2024 using linked primary care and hospital records to define multimorbidity (2 + long-term conditions), and timestamped hospital electronic health record (EHR) contacts with care providers to study patterns and intensity of inpatient care. The primary outcome was emergency hospital readmission within 30 days of discharge, analysed using multivariable logistic regression.
Results
Across 98,242 consecutive admissions, 84% of the study population had multimorbidity, 50% had 4 + long-term conditions, and 37% had both physical and mental health conditions. Both higher condition count and total number of care provider contacts were independently associated with the primary outcome in fully adjusted models (adjusted odds ratio [aOR] 1.61, 95% CI 1.51 to 1.72 for 4 + conditions compared to no multimorbidity, p < 0.001; aOR 1.10, 95% CI 1.03 to 1.17 for > 12 care provider contacts compared to 1–4, p = 0.01). While multimorbidity was associated with longer hospital stays with more contacts, the distribution of contacts and rehabilitation activity did not differ by multimorbidity or emergency readmission status.
Conclusions
Higher count multimorbidity was associated with an increased risk of readmission, but we observed uniformity in care despite differential outcomes across multimorbidity groups. This may suggest that EHR data-driven approaches could inform person-centred care and improve hospital resource allocation.
Comparative Survival Analysis of ChatGPT o1, ChatGPT-4o, and Tumor Board Treatment Recommendations in Head and Neck Squamous Cell Carcinoma - A study of 1757 cases
Authors: Schmidl Benedikt , Hoch Cosima , Shoykhet Maria , Weiser Tobias , Pigorsch Steffi , Stögbauer Fabian , Wollenberg Barbara , Hussain Timon , Wirth Markus 
Published: January 2025

Abstract

(1) Objectives: Artificial intelligence (AI) has demonstrated potential in supporting decision making processes in oncology by assisting the multidisciplinary tumor board (MDT). This study evaluates the performance of two AI-based decision-support tools, the most recently introduced ChatGPT o1 and the established ChatGPT 4o, compared to MDT treatment recommendations in head and neck squamous cell carcinoma (HNSCC). Survival outcomes and treatment patterns were analyzed in a large publicly accessible patient cohort;
(2) Materials and Methods: 1843 HNSCC cases of the University of Michigan SPORE clinical outcomes analytic dataset were analyzed, and 1,757 patients were included in the final study. Treatment recommendations by ChatGPT o1, ChatGPT 4o, and the MDT were compared using clinical data from the cohort. Survival analysis was performed using Kaplan-Meier curves and Cox proportional hazards models, adjusting for confounders such as tumor stage, smoking status, body mass index (BMI), HPV status, and p16 expression. Subgroup analyses by tumor stage and location were conducted, and treatment modalities were compared across the three groups. For validation purposes, the TCGA HNSCC dataset of 528 cases was analyzed;
(3) Results: ChatGPT o1 treatment recommendations yielded significantly better overall survival compared to both ChatGPT-4o and the MDT in unadjusted Kaplan-Meier analysis (log-rank test p < 0.0001). However, the survival advantage was based on a tumor stage distribution bias as ChatGPT o1 favored early-stage patients for its recommendations. After adjustment for covariates, no significant differences were observed in survival between ChatGPT o1, ChatGPT-4o, and the MDT. Tumor stage remained the strongest predictor of survival (HR: 1.34 per stage increment, 95% CI: 1.24–1.44, p < 0.0001). Similar results were also demonstrated in the independent validation TCGA cohort;
(4) Discussion: While ChatGPT o1’s treatment recommendations yielded better survival outcomes in this study; these results were driven mostly by stage-based selection bias. After adjustment, no statistically significant survival advantage was observed among the three treatment groups. Differences in treatment modality preferences and patient selection emphasize potential AI-driven opportunities and potential "outside-the-box" reasoning for personalizing treatment strategies and highlight the importance of stage-stratified analyses when comparing AI-based decision-support tools to traditional tumor boards. This study lays the foundation for the use of ChatGPT o1 in simulating clinical decision-making.
Metabolic Profiling and Substrate Utilization of Hericium erinaceus (Lion’s Mane) Mycelia Isolate Using Biolog Phenotype Microarray
Authors: Boudagga Soumaya , Hamdi Chadlia , Mahmoudi Henda 
Published: January 2025

Abstract

Hericium erinaceus, has long been recognized in traditional Chinese medicine for its extensive health benefits. H. erinaceus is notable for its production of various bioactive compounds. Among these, the terpenoid compounds hericenones and erinacines, derived from fruiting bodies and cultured mycelia respectively, have been particularly highlighted for their ability to stimulate nerve growth factor (NGF) synthesis, contributing to the mushroom's neuroprotective properties. This study focuses on the metabolic characterization of H. erinaceus mycelium using the Biolog Phenotype MicroArray (PM) technology, a high-throughput method for analyzing microbial growth phenotypes. For the first time, Biolog PMs were applied to elucidate a comprehensive nutritional utilization profile of H. erinaceus. The study involved testing 950 different conditions, including 190 carbon sources, 380 nitrogen sources, 94 biosynthetic pathways, 59 phosphorus sources, 35 sulfur sources, 96 osmotic pressures, and 96 pH conditions. The results revealed that H. erinaceus has a relatively restricted carbon utilization profile, efficiently utilizing only 23 out of 190 carbon sources, mainly simple sugars and certain complex carbohydrates like D-Cellobiose, D-Xylose, and Arbutin. The mycelium also demonstrated effective growth on various nitrogen sources, particularly Urea and D-glucosamine, and was capable of growing on all sulfur sources and most phosphorus sources with few exceptions. Additionally, H. erinaceus exhibited growth under 94 biosynthetic pathways, 65 osmotic pressures, and 56 pH conditions tested. This detailed metabolic characterization not only enhances our understanding of H. erinaceus' nutritional requirements and metabolic capabilities but also provides valuable insights into its potential applications in the development of functional foods and alternative medicines.
Atractyloside-A ameliorates spleen deficiency diarrhea in mice by modulating Lactobacillus johnsonii to enhance butyrate production, activating GPR43, and inhibiting the assembly of NLRP3
Authors: Xiao Yangxin , Ke Chang , Wang Dongpeng , Chen Niping , Chen Gaoyuan , Qu Linghang , Liu Yanju 
Published: January 2025

Abstract

Background
Spleen-deficiency diarrhea (SDD) is recognized in Traditional Chinese Medicine (TCM) as a prevalent gastrointestinal ailment, primarily characterized by chronic and persistent diarrhea, akin to classifications in Western medicine. The disruption of the intestinal barrier and the appearance of intestinal inflammation are the direct causes of the occurrence of SDD. Therefore, restoring the integrity of the intestinal barrier and reducing inflammation is an important strategy for relieving SDD. Atractyloside-A (AA), a major bioactive compound derived from the post-processing of Atractylodes lancea (Thunb.) DC., is recognized as a crucial component that enhances the spleen-strengthening effects following the processing of this herb. Previous studies have indicated that AA is effective in treating SDD through the modulation of gut microbiota; however, the specific molecular mechanisms underlying this effect remain unclear. This study aimed to elucidate the molecular pathways by which AA exerts its therapeutic effects on SDD.
Results
This study showed that AA significantly increased the abundance of Lactobacillus johnsonii, promoted butyrate production, enhanced GPR43 expression, and modulated the TLR4/NF-κB signaling pathway. This modulation inhibited the assembly of the NLRP3 inflammasome, alleviated inflammation, reversed mucin synthesis damage, and reduced the pathological symptoms associated with SDD. Moreover, administration of Lactobacillus johnsonii, NaB, and SCFAs individually resulted in significant improvements in various SDD-related phenotypes. However, the beneficial effects of AA and NaB were abolished following the administration of AAV-shGPR43.
Conclusion
AA enhances butyrate production by regulating Lactobacillus johnsonii, activates GPR43, and inhibits the assembly of the NLRP3 inflammasome through modulation of the TLR4/NF-κB pathway, thereby ameliorating SDD in mice.
CAS-FGvit: An Efficient Convolutional Additive Mixer for Fine-Grained Classification
Authors: Zhang Fangyan , Wu Pengju , Hu Chunsheng , An Wei , Liang Xiaojie 
Published: January 2025

Abstract

Fine-grained visual classification (FGVC) aims to recognize objects from subcategories, which is a very challenging task due to the subtle inter-class differences in nature. Most existing works mainly address this problem by reusing the backbone network to extract features of detected discriminative regions. However, this strategy inevitably complicates the process and forces the proposed regions to contain large parts of the object, thus failing to find the truly important parts. Recently, Convolutional Additive Visual Transformer (CAS-ViT) has shown outstanding performance in traditional classification tasks. In this work, we first evaluate the effectiveness of the CAS-ViT framework in the fine-grained recognition setting. First, we propose a part selection module that integrates all the original attention weights of the Transformer into the attention map to guide the network to effectively and accurately select discriminative image patches and compute their relations. Then, we propose an efficient multi-scale attention module to further reduce the computational workload. The enhanced model based on CAS-ViT is named CAS-FGvit and demonstrated its value by conducting experiments on the Lycium barbarum dataset and three popular fine-grained benchmarks, where we achieve state-of-the-art performance. To better understand our model, we present qualitative results.
Direct synthesis of an iron metal-organic framework antiferromagnetic glass
Authors: Espallargas Guillermo Minguez , León-Alcaide Luis , Martínez-Goyeneche Lucía , Sessolo Michele , Vieira Bruno , Waerenborgh Joao , Rodríguez-Velamazán José , Fabelo Oscar , Cliffe Matthew , Keen David 
Published: January 2025

Abstract

Glasses are ubiquitous in our everyday lives but still pose fundamental questions about the nature of order in solids. Typically formed by the rapid cooling of a liquid, these amorphous solids have broad applications, with vitreous silica (SiO2) the most well-known example.1 Most functional glasses are purely inorganic solids, restricting the range of functional properties feasible.2 Recently, a number of new metal-organic framework (MOF) glasses containing molecular components has been discovered by heating their crystalline counterparts to a melting point followed by a rapid cooling, thereby expanding the potential applications of glass materials.3–5 However, the melt-quenched (MQ) approach is limited to MOFs that melt, which is very restrictive as most MOFs readily decompose at heating to comparatively low temperatures.6 The low decomposition temperatures mean that glassy MOF samples typically include impurity decomposition products detrimental to functionality, as optical, electronic and magnetic contaminants. In this work, we present a direct route to prepare a family of MOF glasses without a meltable crystalline precursor. This route produces high-purity iron (II) MOF glasses, avoiding the oxidation and partial degradation commonly associated with the conventional melt-quenching process. The absence of magnetic impurities allows us to study the magnetic properties of the MOF glass itself and show that MOF glasses are good model systems for topologically disordered amorphous antiferromagnets. We also present the functional advantages of direct-glass synthesis by creating free-standing films of glassy MOFs and integrating them in optoelectronic devices. Direct-glass synthesis is thus a powerful route to exploit the true functional potential of glassy MOFs, not only realizing new MOF glasses but also unveiling properties that can be accessed with these materials.7