bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight into the interaction of pluronic F‐127 functionalized boron nitride nanosheets with piezoelectric poly(l‐lactic acid) nanofiber scaffolds for bone tissue engineering applications
Authors: Sekkarapatti Ramasamy Madeshwaran , Krishnamoorthi Kaliannagounder Vignesh , Ramasamy Shanmugam , Kumar Vineet , Park Sung Jea , Park Sang Shin , Park Chan Hee , Han Sung Soo , Kim Cheol Sang , Kim Byungki 
Published: August 2023

AbstractOwing to their superior mechanical properties, good biocompatibility, biodegradability, and piezoelectric behavior, boron nitride (BN) nanostructures have received significant attention in the biomedical field, including filler in biopolymer composites, drug delivery, and cell stimulation. Nevertheless, the functionalization of BN is essential to overcome their strong agglomeration tendency in solvents and enhance their dispersibility and interfacial interaction with polymer matrix. Herein, we report an efficient dual functionalization approach for BN nanosheets (BNNS) using oleylamine (OLA) and pluronic F127 (PLU). First, BNNS has functionalized with OLA via Lewis acid–base interactions between the amino groups of OLA and the boron atoms of BNNS and then followed by PLU via noncovalent interactions. The composites of PLU‐functionalized boron nitride nanosheets (PLUBN) were reinforced into poly(l‐lactic acid) nanofiber (PLF) matrix, and subsequent changes in physiochemical, mechanical, and piezoelectric properties were reported in a concentration‐dependent manner. In addition, the density functional theory (DFT) calculations demonstrate the significant interaction between PLUBN and PLF. Further, in vitro studies with the preosteoblast (MC3T3‐T1) cells evidenced decent biocompatibility and proliferation with enhanced osteogenic differentiation potentials for the composite scaffolds. Thus, in the future, the reported effective strategy could be employed for preparing BNNS‐based piezoelectric biopolymer composites for tissue engineering applications.
The curse of the thinking woman: Encoded misogyny in the brilliant female detective
Authors: Tutter Adele 
Published: August 2023

AbstractThe enormously popular contemporary genre of televised police procedurals that feature a brilliant female detective reflects and reifies enduring misogynistic beliefs and attitudes that pervade the cultural fantasies and social mores of our time. In her current form, the prototypical female protagonist of these series adheres to a rigid, stereotypical formulation that limits her capacity for mature, healthy object relations. In particular, her singular devotion to her work badly compromises her maternal function: thus, she is either barren or a bad mother, as well as a bad partner, sister, or daughter. Moreover, her professional excellence is itself pathologized, as the very qualities that make her extraordinary are typically attributable to the quintessential misogynistic trope of mental illness or emotional instability. The Greek myth of the birth of Athena explicates the threat embodied by the brilliant female detective, who, as a revival of the infantile fantasy of the all‐powerful, all‐knowing mother, infringes on the generative capacity of the mind: territory that men have since antiquity claimed in order to guard against envy of female procreative power. In return, she must be divested of her uniquely female powers, “the curse of the thinking woman.”
Design of Glycopolymers for Controlling the Interactions with Lectins
Authors: Nagao Masanori , Matsumoto Hikaru , Miura Yoshiko 
Published: August 2023

AbstractCarbohydrates are involved in life activities through the interactions with their corresponding proteins (lectins). Pathogen infection and the regulation of cell activity are controlled by the binding between lectins and glycoconjugates on cell surfaces. A deeper understanding of the interactions of glycoconjugates has led to the development of therapeutic and preventive methods for infectious diseases. Glycopolymer is one of the classes of the materials present multiple carbohydrates. The properties of glycopolymers can be tuned through the molecular design of the polymer structures. This review focuses on research over the past decade on the design of glycopolymers with the aim of developing inhibitors against pathogens and manipulator of cellular functions.
Navigating educational success: Modes of expectation among care‐experienced young people
Authors: Mølholt Anne‐Kirstine , Bengtsson Tea Torbenfeldt , Frederiksen Morten 
Published: August 2023

AbstractThis paper explores modes of expectation among care‐experienced young people when navigating educational success. Luhmann's theoretical framework is used to conceptualise experiences of educational success and the role of uncertainty. We identify three modes of expectation: trust, risk and danger. To illustrate these modes, we draw on selected examples from an interview study with 28 care‐experienced young people focusing on their experiences of support and aftercare while transitioning out of care. The trust mode of expectation is based in a confidence that the future entails a positive outcome—in the case of this study, regarding educational success. This expectation is characterised by the young person's feelings of belonging, underpinned by a safety net of unconditionally supportive caregivers. The risk mode of expectation is characterised by the young person's feeling of being overwhelmed and burdened by the complexity of the educational system in combination with unknown future circumstances when leaving care. The battle against child welfare services to keep supportive measures increases levels of uncertainty. The danger mode of expectation emerges when educational success is disrupted by the interference of child welfare services. The system is seen as unpredictable and powerful, making the young person withdraw from formal support. We conclude that educational success for care‐experienced young people is closely linked to their mode of expectation with regard to managing the uncertainty of the future and that their mode is highly dependent on their social, institutional and biographical contexts.
The Deposition of Isolated Fe(3+) Species in Mesoporous Silicon for Oxidation of Cyclohexane
Authors: Zhai Liming , Zhang Bin , Li Haitao , Jiang Min , Yang Xinchun , Li Zhuo , Zhao Shichao , Qin Yong 
Published: August 2023

AbstractThe balance of activity and selectivity in liquid alkane oxidation is challenging for the design of supported Fe catalysts. When Fe species leach to the solvent, uncontrolled free radical chain reactions happen. Herein, isolated Fe(3+) species were constructed by forming a strong Fe−O−Si bond for the selective oxidation of cyclohexane to cyclohexanone by H2O2. Compared to the supported FeOx clusters, the strong Fe−O−Si bond between isolated Fe(3+) species and SiO2 prevents the leaching of Fe in strong oxidation (H2O2) reaction conditions and dominates the non‐free radical mechanism. The turnover frequency over 10FeOx/SBA‐15 reached 15.2 h−1, higher than for reported Fe‐based catalysts. High selectivity of cyclohexanone is maintained at different conversions. Moreover, the (SiO)xFe3+(OH)3‐x−OOH active species were detected by Raman and FTIR and are generated from the oxidation of isolated Fe species. The strong Fe−O−Si bond and non‐free‐radical mechanism by (SiO)xFe3+(OH)3‐x−OOH active species induce high activity and selectivity for the oxidation of many other alkanes.
Retracted: Aggregation‐Induced Emission‐Active Donor‐Substituted Aroyl‐S,N‐Ketene Acetals via Nucleophilic Amine Base Attack
Authors: Biesen Lukas , Müller Thomas J. J. 
Published: August 2023

AbstractDonor‐substituted aroyl‐S,N‐ketene acetals can be rapidly obtained by nucleophilic attack of triethylamine at the acid chloride with concomitant decarbonylation followed by addition‐elimination reaction of in situ generated enamines. These potent chromophores exhibit intensive solid‐state emission and pronounced AIE (aggregation‐induced emission) characteristics with high quantum yields. By changing the base to diisopropylethylamine, enlarged aroyl‐S,N‐ketene acetal bi‐ and trichromophores are easily accessible.
Chemiluminescence‐Based Assay to Monitor Early Oxidative Bursts in Soybean (Glycine max) Lateral Roots
Authors: Sivaramakrishnan Muthusaravanan , Goel Sakshi , Ratnaparkhi Nikhil , Chandrasekar Balakumaran 
Published: August 2023

AbstractThe reactive oxygen species (ROS) burst assay is a valuable tool for studying pattern‐triggered immunity (PTI) in plants. During PTI, the interaction between pathogen recognition receptors (PRRs) and pathogen‐associated molecular patterns (PAMPs) leads to the rapid production of ROS in the apoplastic space. The resultant ROS can be measured using a chemiluminescent approach that involves the usage of horseradish peroxidase and luminol. Although several methods and protocols are available to detect early ROS bursts in leaf tissues, no dedicated method is available for root tissues. Here, we have established a reliable method to measure the PAMP‐triggered ROS burst response in soybean lateral roots. In plants, lateral roots are the potential entry and colonization sites for pathogens in the rhizosphere. We have used important PAMPs such as chitohexaose, flagellin 22 peptide fragment, and laminarin to validate our method. In addition, we provide a detailed methodology for the isolation and application of fungal cell wall components to monitor the oxidative burst in soybean lateral roots. Furthermore, we provide methodology for performing ROS burst assays in soybean leaf discs with laminarin and fungal cell walls. This approach could also be applied to leaf and root tissues of other plant species to study the PTI response upon elicitor treatment. © 2023 Wiley Periodicals LLC.Basic Protocol: Reactive oxygen species (ROS) burst assay in soybean lateral root tissuesAlternate Protocol: ROS burst assay in soybean leaf discsSupport Protocol: Isolating fungal cell wall fractions
Potential use of wild Onobrychis species for climate change mitigation and adaptation
Authors: Sakhraoui Anis , Ltaeif Hela B. , Sakhraoui Asma , Rouz Slim , Castillo Jesús M. 
Published: August 2023

AbstractClimate change is threatening environmental and nutritional security. In this scenario, forage crops and their wild relatives may contribute to maintain ecosystem services and minimize the effects of global warming. We reviewed the literature regarding the ecological, agronomic, and nutraceutical values of wild Onobrychis Miller species (sainfoins, Family Fabaceae). We also discussed their application prospects and the existing problems hampering their widespread domestication. Wild species of the genus Onobrychis have some interesting agronomic and ecological features such as perenniality, deep root system, and high‐stress tolerance, which make them suitable for future cultivation under climate change. Wild Onobrychis species are multipurpose species, which can be utilized for fodder and honey production under harsh environmental conditions. In addition, wild Onobrychis species water, ethanol, and methanol extracts exhibit antioxidant, antidiabetic, anti‐inflammatory, antitumor, antimicrobial, anti‐stressor, and many other pharmacological effects. Wild Onobrychis species have not been the subject of detailed studies. Compared with the cultivated forage legumes, wild Onobrychis species are still underexploited despite their potential to alleviate forage and food insecurity, either by domestication or by providing novel alleles for breeding purposes of the cultivated species Onobrychis viciifolia. Our review aims to increase scientific awareness toward exploring the potential uses of wild Onobrychis species to tackle current climate change.
A single‐source nine‐level boost inverter with new optimal switching scheme for EV applications
Authors: Aditya Kancharapu , Suresh Yellasiri , Shiva Naik Banavath , Nageswar Rao B , Panda A K 
Published: August 2023

SummaryThe importance of two‐level inverters is well known in EV applications; it contains significant unwanted harmonics in generated voltage. One of the most efficient way to increase power quality is to replace a two‐level inverter with a multilevel inverter (MLI). The MLI's essence considerably reduces total harmonic distortion. Eventually, the size of the filter requirement also will minimize. Because of the increased device count and capacitor voltage balance issues, these converters have a slew of reliability concerns. To mitigate these drawbacks, a novel switched‐capacitor based nine‐level inverter (SC‐NLI) structure with a new optimal control switching technique for electric vehicle (EV) applications is proposed in this paper. The proposed SC‐NLI structure comprises 10 switches, one diode, and two capacitors. The proposed structure's circuit description, modes of operation, proper component selection, and a new optimal switching scheme are presented. A discussion about the comparative analysis of suggested topology with currently developed MLI structures is presented. In addition, to the simulation results, experimental tests are conducted under various load conditions to evaluate the proposed SC‐NLI structure.
Directional and stabilizing selection shaped morphological, reproductive, and physiological traits of the invader Solidago canadensis
Authors: Du Leshan , Oduor Ayub M. O. , Zuo Wei , Liu Haiyan , Li Jun‐Min 
Published: August 2023

AbstractTrait evolution in invasive plant species is important because it can impact demographic parameters key to invasion success. Invasive plant species often show phenotypic clines along geographic and climatic gradients. However, the relative contributions of natural selection and neutral evolutionary processes to phenotypic trait variation among populations of invasive plants remain unclear. A common method to assess whether a trait has been shaped by natural selection or neutral evolutionary processes is to compare the geographical pattern for the trait of interest to the divergence in neutral genetic loci (i.e., QST–FST comparisons). Subsequently, a redundancy analysis (RDA) can facilitate identification of putative agents of natural selection on the trait. Here, we employed both a QST–FST comparisons approach and RDA to infer whether natural selection shaped traits of invasive populations of Solidago canadensis in China and identify the potential environmental drivers of natural selection. We addressed two questions: (1) Did natural selection drive phenotypic trait variation among S. canadensis populations? (2) Did climatic, latitudinal, longitudinal, and altitudinal gradients drive patterns of genetic variation among S. canadensis populations? We found significant directional selection for several morphological and reproductive traits (i.e., QST > FST) and stabilizing selection for physiological traits (i.e., QST < FST). The RDA showed that stem biomass of S. canadensis was strongly positively correlated with longitude, while leaf width ratio and specific leaf area were significantly positively correlated with the mean diurnal range. Stem biomass had a strong negative correlation with annual precipitation. Moreover, height of S. canadensis individuals was strongly positively correlated with altitude and precipitation of the wettest quarter. A longitudinal shift in precipitation seasonality likely selected for larger stem biomass in S. canadensis. Overall, these results suggest that longitudinal and altitudinal clines in climate exerted strong selection pressures that shaped the phenotypic traits of S. canadensis.
Copper(I)‐Catalyzed Interrupted Click Reaction: Synthesis of 1,4,5‐Trisubstituted 5‐Chloro‐1,2,3‐Triazoles
Authors: Wu Qiming , Song Wangze 
Published: August 2023

Abstract5‐Halo‐1,2,3‐triazoles are important scaffolds in organic chemistry, but current click reactions cannot produce 1,4,5‐trisubstituted 5‐chloro‐1,2,3‐triazoles in a simple way. Herein, we disclosed a Cu(I)‐catalyzed interrupted click reaction, using N‐chlorophthalimide as an electrophilic chlorine source, enabling the facile synthesis of 1,4,5‐trisubstituted 5‐chloro‐1,2,3‐triazoles in one step from readily available terminal alkynes and azides. Complete control of regioselectivities with a broad substrate scope was accomplished by this approach. Furthermore, a novel epoxidation was developed using 5‐chloro‐triazole as substrate, which could be further applied in various organic transformations.
Water storage of a typical tree species in the Caatinga biome (Caesalpinia pyramidalis Tul.)
Authors: Costa Juliana Alcântara , Vellame Lucas Melo , Costa Carlos Alexandre Gomes , Navarro‐Hevia Joaquín , de Lacerda Claudivan Feitosa , de Figueiredo José Vidal , de Araújo José Carlos 
Published: August 2023

AbstractOur understanding of the movement and storage of water in typical Caatinga plants is still limited and often disregarded in water balance calculations. This is why the objective of this work was to evaluate the water storage dynamic in typical trees of the Caatinga biome during the dry, rainy and transition period by gauging the water content levels that cause the onset of leaf emergence. In a preserved Caatinga forest, soil and stem water content of six trees of the representative species catingueira (Caesalpinia pyramidalis Tul.) were monitored with low‐cost capacitive sensors. Leaf moisture, leaf area index, leaf and stem water volume, and sap flow density were measured. The emergence of leaves occurred with a stem moisture of 0.32 m3 m−3, and the leaf area index was maximum with a stem moisture of 0.34 m3 m−3. Catingueira plants are able to absorb water below the soil water potential commonly determined as the permanent wilting point (−1.5 MPa). The volume of water stored in the plants represents 108% of the average volume stored in the Boqueirão reservoir during the study period.
The role of open government data and information and communication technology in meeting the employment‐related information needs of unemployed South African youth
Authors: Masavah Vincent Mwendwa , van der Merwe Ronell , van Biljon Judy 
Published: August 2023

AbstractOpen government data (OGD) and information and communication technologies (ICT) are potential enablers in meeting information needs related to finding employment opportunities, but there is little evidence‐based theorization to guide this enablement and avoid the barriers that hinder its use. The potential economic contribution of OGD has been researched in depth, but the potential of OGD for human development, specifically in developing countries, has not been theorized substantially. Therefore, this study aimed to investigate “how the role of ICT and OGD in meeting the employment‐related information needs of unemployed South African youth can be understood better by the application of the Choice Framework”. The Choice Framework is Kleine's analytical tool for investigating ICTs for development toward a contextualized understanding of the relationships among the framework's elements, namely structure, agency, the dimension of choice and development outcomes. The research design was a single, exploratory case study; the data was collected in Alexandra Township of the Gauteng Province in South Africa using semi‐structured interviews. Data was collected from 34 participants (between the ages of 18 and 35) who were looking for employment. The data was analyzed thematically and then unpacked in terms of the constructors of the Choice Framework. The findings show that most participants had access to ICT but limited awareness of OGD, and several challenges in using OGD for finding employment‐related information were identified. The findings provide a theory‐based contextual understanding of the research space, including the challenges and recommendations for overcoming said challenges of finding information on employment opportunities.
Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy
Authors: Newell Stella , van der Watt Pauline J. , Leaner Virna D. 
Published: August 2023

AbstractSystemic modalities are crucial in the management of disseminated malignancies and liquid tumours. However, patient responses and tolerability to treatment are generally poor and those that enter remission often return with refractory disease. Combination therapies provide a methodology to overcome chemoresistance mechanisms and address dose‐limiting toxicities. A deeper understanding of tumorigenic processes at the molecular level has brought a targeted therapy approach to the forefront of cancer research, and novel cancer biomarkers are being identified at a rapid rate, with some showing potential therapeutic benefits. The Karyopherin superfamily of proteins is soluble receptors that mediate nucleocytoplasmic shuttling of proteins and RNAs, and recently, nuclear transport receptors have been recognized as novel anticancer targets. Inhibitors against nuclear export have been approved for clinical use against certain cancer types, whereas inhibitors against nuclear import are in preclinical stages of investigation. Mechanistically, targeting nucleocytoplasmic shuttling has shown to abrogate oncogenic signalling and restore tumour suppressor functions through nuclear sequestration of relevant proteins and mRNAs. Hence, nuclear transport inhibitors display broad spectrum anticancer activity and harbour potential to engage in synergistic interactions with a wide array of cytotoxic agents and other targeted agents. This review is focussed on the most researched nuclear transport receptors in the context of cancer, XPO1 and KPNB1, and highlights how inhibitors targeting these receptors can enhance the therapeutic efficacy of standard of care therapies and novel targeted agents in a combination therapy approach. Furthermore, an updated review on the therapeutic targeting of lesser characterized karyopherin proteins is provided and resistance to clinically approved nuclear export inhibitors is discussed.
Design and development of a patient‐specific temporomandibular joint implant: Probing the influence of bone condition on biomechanical response
Authors: Banerjee Anik , Basu Bikramjit , Saha Subrata , Chowdhury Amit Roy 
Published: August 2023

AbstractTotal temporomandibular joint (TMJ) replacement is widely recognized as an effective treatment for TMJ disorders. The long‐term stability of TMJ implants depends on two important factors which are design concepts for fixation to anatomical locations in the mandible and bone conditions. Other factors include stress distribution, microstrain in the peri‐implant, bone attributes like bone conditions leading to the clinical complications and failures. This study addresses these limitations by examining the influence of patient‐specific design concepts and bone conditions on TMJ implant performance. Clinical evidences support the importance of implant design on healing ability. Previous studies have focused on achieving precise implant fit based on geometric considerations, however those published studies did not explore the impact of such. Against this perspective, the present study reports the extensive finite element analysis (FEA) results, while analyzing the impact of a newly designed patient‐specific TMJ implant to address clinical complications associated with various bone conditions, particularly osteoporotic bone. In validating the FEA results, the performance of additively manufactured patient‐specific TMJ implants was compared with designs resembling two commonly used clinically approved implant designs. By addressing the limitations of previous research and emphasizing the importance of bone conditions, the study provides valuable guidelines for the development of next‐generation TMJ implants. These findings contribute to enhanced clinical outcomes and long‐term success in the treatment of TMJ disorders.