bluuebunny/crossref_metadata_2025_split huggingface dataset:
Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis
Authors: Wang Junjun , Song Linfeng , Tian Binlin , Yang Li , Gu Xiaoyu , Chen Xu , Gao Lei , Jiang Lin 
Published: January 2025

Background and purposeAsymptomatic carotid stenosis (ACS) is an independent risk factor for ischemic stroke and vascular cognitive impairment, affecting cognitive function across multiple domains. This study aimed to explore differences in static and dynamic intrinsic functional connectivity and temporal dynamics between patients with ACS and those without carotid stenosis.MethodsWe recruited 30 patients with unilateral moderate-to-severe (stenosis ≥ 50%) ACS and 30 demographically-matched healthy controls. All participants underwent neuropsychological testing and 3.0T brain MRI scans. Resting-state functional MRI (rs-fMRI) was used to calculate both static and dynamic functional connectivity. Dynamic independent component analysis (dICA) was employed to extract independent circuits/networks and to detect time-frequency modulation at the circuit level. Further imaging-behavior associations identified static and dynamic functional connectivity patterns that reflect cognitive decline.ResultsACS patients showed altered functional connectivity in multiple brain regions and networks compared to controls. Increased connectivity was observed in the inferior parietal lobule, frontal lobe, and temporal lobe. dICA further revealed changes in the temporal frequency of connectivity in the salience network. Significant differences in the temporal variability of connectivity were found in the fronto-parietal network, dorsal attention network, sensory-motor network, language network, and visual network. The temporal parameters of these brain networks were also related to overall cognition and memory.ConclusionsThese results suggest that ACS involves not only changes in the static large-scale brain network connectivity but also dynamic temporal variations, which parallel overall cognition and memory recall.
Predictive value of lymphocyte-associated inflammation index in post-stroke cognitive impairment: a systematic review and meta-analysis
Authors: Mao Feng-le , He Xia , Huang Xia-lian , Cheng Yue-ming , Qin Fu-li , Wang Yan-qiu 
Published: January 2025

BackgroundThe predictive role of the lymphocyte-associated inflammation index in post-stroke cognitive impairment (PSCI) remains controversial. Therefore, we performed an updated meta-analysis to update the evidence.MethodsThis meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Six databases were systematically searched from their inception to May 5, 2024. Two investigators independently conducted literature screening and data extraction for the included studies. Two investigators independently assessed the quality of the included studies using the Newcastle-Ottawa Scale (NOS). Combined effect sizes were calculated using weighted mean difference (WMD) or standardized mean difference (SMD) with 95% confidence intervals (CIs). Heterogeneity was tested using the chi-square (χ2) test (Cochran’s Q) and index of inconsistency (I2), Publication bias was assessed using funnel plots and Egger’s regression test.ResultsThis systematic review included a total of 16 studies, encompassing 3,406 patients. Meta-analysis revealed that neutrophil-to-lymphocyte ratio (NLR) levels were significantly higher in the PSCI group compared to the non-PSCI group (WMD: 1.12; 95% CI: 0.85, 1.40; p &lt; 0.00001). Similarly, the platelet-to-lymphocyte ratio (PLR) levels were significantly higher in the PSCI group compared to the non-PSCI group (WMD: 16.80; 95% CI: 4.30, 29.29; p = 0.008). However, there was no statistically significant difference between the two groups concerning hemoglobin, albumin, lymphocyte, and platelet (HALP) scores (WMD: -12.78; 95% CI: −25.95, 0.38; p = 0.06) and lymphocyte count (WMD: -0.13; 95% CI: −0.34, 0.07; p = 0.20).ConclusionIncreased levels of PLR and NLR are strongly associated with the PSCI, which may serve as an effective tool for predicting PSCI. However, there is insufficient evidence to support a direct relationship between HALP scores, lymphocyte count, and PSCI.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023462232.
Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study
Authors: Lin Liaoyi , Huang Yingbao , Qian Songzan , Chen Lifang , Sun Houzhang 
Published: January 2025

BackgroundRecent studies have increasingly emphasized the strong correlation between the lipidome and the risk of pancreatic diseases. To determine causality, a Mendelian randomization (MR) analysis was performed to identify connections between the lipidome and pancreatic diseases.MethodsStatistics from a genome-wide association study of the plasma lipidome, which included a diverse array of 179 lipid species, were obtained from the GeneRISK cohort study with 7,174 participants. Genetic associations with four types of pancreatitis and pancreatic cancer were sourced from the R11 release of the FinnGen consortium. Two pancreatitis datasets from UK Biobank were employed as the validation cohort. MR analysis was conducted to assess the relationship between the genetically predicted plasma lipidome and these pancreatic diseases. Inverse variance weighted was adopted as the main statistical method. Bayesian weighted MR was employed for further verification. The MR-Egger intercept test for pleiotropy and Cochrane's Q statistics test for heterogeneity were performed to ensure the robustness.ResultsMR analysis yielded significant evidence that 26, 25, 2, and 19 lipid species were correlated with diverse outcomes of pancreatitis, and 8 lipid species were correlated with pancreatic cancer. Notably, sterol ester (27:1/20:2) levels (OR: 0.84, 95% CI: 0.78–0.90, P = 5.79 × 10−7) were significantly associated with acute pancreatitis, and phosphatidylcholine (17:0_20:4) levels (OR: 0.89, 95% CI: 0.84–0.94, P = 1.78 × 10−4) and sterol ester (27:1/20:4) levels (OR: 0.90, 95% CI: 0.86–0.95, P = 2.71 × 10−4) levels were significantly associated with chronic pancreatitis after the Bonferroni-corrected test. As for validation, 14 and 9 lipid species were correlated with acute and chronic pancreatitis of UK Biobank. Some lipid classes showed significant effects both in the FinnGen consortium and UK Biobank datasets.ConclusionsThe findings of this study indicate a potential genetic predisposition linking the plasma lipidome to pancreatic diseases and good prospects for future pancreatic disease clinical trials.
Sugar-sweetened beverages, relative grip strength, and psychological symptoms among rural adolescents in western China: a cross-sectional study
Authors: Zhang Yanni , Xiong Jianping , Sun Rong , Chai Guangxin , Xiong Li 
Published: January 2025

BackgroundThe increasing prevalence of psychological symptoms in adolescents has become an important problem faced by all countries in the world. The increased sugar-sweetened beverages (SSB) consumption and the decreased muscle strength had a serious negative impact on adolescent health. However, previous studies have mainly focused on adolescents in developed countries and fewer studies have been conducted in developing countries, especially in rural areas of western China. This study aims to explore the association of sugar-sweetened beverages consumption, and relative grip strength with psychological symptoms among rural adolescents in western China.MethodsIn this study, 11,018 adolescents aged 13–18 years from rural areas of Xinjiang and Tibet in western China were recruited using stratified randomized whole-cluster sampling in 2023. The participants were assessed for sugar-sweetened beverages consumption, relative grip strength, and psychological symptoms. Non-parametric tests, t-tests, logistic regression analyses, and ordered logistic regression analyses of generalized linear models were used to analyze the associations of sugar-sweetened beverage consumption and relative grip strength with psychological symptoms in adolescents.ResultsThe proportions of adolescents with sugar-sweetened beverages consumption of &lt;1 times/week, 2–4 times/week, and &gt;4 times/week in rural areas of western China were 34.6, 52.7, and 12.7%, respectively. The prevalence of adolescents’ emotional problems, behavioral problems, social adjustment difficulties, and psychological symptoms were 28.7, 27.0, 20.2, and 22.1%, respectively. The mean and standard deviation of grip strength among adolescents was assessed as (32.52 ± 10.13) kg and the relative grip strength was (0.60 ± 0.16) in rural areas of western China. Taking participants with sugar-sweetened beverages consumption &lt;1 times/week group and relative grip strength at the fourth quartile as the reference, participants with SSB consumption &gt;4 times/week and relative grip strength at the first quartile had the highest risk (OR = 2.77, 95% CI: 2.09–3.67, p &lt; 0.001) of psychological symptoms.ConclusionElevated sugar-sweetened beverages consumption and decreased relative grip strength were associated with an increased prevalence of psychological symptoms. Prospective cohort studies are needed in the future to explore the causal relationships among SSB consumption, muscle strength, and psychological symptoms.
Drug-induced heart failure: a real-world pharmacovigilance study using the FDA adverse event reporting system database
Authors: Huang Youqi , Chen Xiaowen , Chen Mingyu , Lin Yuze , Chen Bingqi , Gao Hongjin , Chen Min 
Published: January 2025

ObjectiveAlthough there are certain drug categories associated with heart failure (HF), most of the associated risks are unclear. We investigated the top drugs associated with HF and acute HF (AHF) reported in the FDA Adverse Event Reporting System (FAERS).MethodsWe reviewed publicly available FAERS databases from 2004 to 2023. Using the search terms “cardiac failure” or “cardiac failure acute” and classifying cases by drug name, we processed and analyzed drug reports related to HF or AHF.ResultsFrom 2004 to 2023, 17,379,609 adverse drug events were reported by FAERS, of which 240,050 (1.38%) were reported as HF. Among those with HF, the male-to-female ratio was 0.94% and 52.37% were &gt;65 years old; 46.2% were from the United States. There were 5,971 patients with AHF. We identified 38 drugs and 13 drug classes with a potential high risk of causing HF, and 41 drugs and 19 drug classes were associated with AHF. The median onset times of HF and AHF were 83 days (IQR: 11–416) and 49 days (IQR: 8–259), respectively. The Weibull shape parameter (WSP) test showed early failure-type profile characteristics.ConclusionThis study highlights key drugs associated with drug-induced HF and AHF, emphasizing the importance of early risk assessment and close monitoring, particularly during the initial stages of treatment. These findings contribute to a better understanding of drug-induced HF and provide a basis for future research on its underlying mechanisms.
The relationship between moral sensitivity and prosocial behavior in college students: the mediating roles of moral disengagement and reciprocity norms
Authors: Li Zhiyong , Wang Danqi , Liao Junhe , Jin Zhibin 
Published: January 2025

IntroductionThis study examined the relationship between moral sensitivity and prosocial behavior, as well as the mediating role of moral disengagement and reciprocity norms.MethodsTotally 567 college students completed Dispositional Moral Sensitivity Questionnaire, Moral Disengagement Scale for Chinese Students, Reciprocity Norm Scale, Prosocial Tendencies Measure for Adolescent.ResultsThe results showed that, moral disengagement and reciprocity norms played multiple mediating roles between moral sensitivity and prosocial behavior. Specifically, moral sensitivity affected prosocial behavior through the independent mediating effect of moral disengagement, reciprocity norms, as well as the chain mediating effect of moral disengagement and reciprocity norms.DiscussionIn summary, this study reveals the mechanism underlying the relationship between moral sensitivity and prosocial behavior, which has certain theoretical and practical significance for promoting college students’ prosocial behavior from the perspective of moral sensitivity.
The effects of heritage multilingualism on foreign language learning: a comparison of children with typical language development and developmental language disorder
Authors: Tribushinina Elena , Boz Betül 
Published: January 2025

IntroductionBoth multilingualism and developmental language disorder (DLD) may be associated with inferior performance in the majority language, albeit for different reasons. At the same time, there is a growing body of evidence that multilingualism may have a positive effect on foreign language performance. This study tests the hypothesis that the positive effects of multilingualism on foreign language learning may be smaller in children with DLD compared to their multilingual peers with typical language development.MethodsIn a 2 × 2 design, we compare the effects of multilingualism and DLD on English as a foreign language performance and majority language performance of multilinguals and monolinguals with and without DLD. The participants were primary school children (aged 9–13) acquiring Dutch as the majority language and learning English as a school subject. English skills were measured with a vocabulary test, a grammar test and the Multilingual Assessment Instrument for Narratives (MAIN). Dutch skills were assessed with the Litmus Sentence Repetition Task and the MAIN task. The MAIN narratives in both languages were analyzed for fluency, lexical diversity, syntactic complexity and grammatical accuracy. The control variables included age, working memory, declarative memory, procedural memory and (for English) amount of extracurricular exposure and length of instruction. Data were analyzed by means of multilevel linear regression.ResultsThe results demonstrate that both multilingualism and DLD were associated with lower scores on the Dutch Sentence Repetition Task and lower grammatical accuracy of narratives. In English, the multilinguals outperformed monolinguals on all measures, except grammatical accuracy of narratives, and the interactions between Background and Group were not significant. Another strong predictor of EFL performance, along with the multilingual status, was extracurricular exposure to English.
A cross-lagged analysis of the relationship between marital quality and depression among the older adults: gender effects of socioeconomic status
Authors: Fang Bi-Ji , Leong Kai-Seng , Tan Hong-Xiu 
Published: January 2025

ObjectiveThis study aimed to explore the mechanism and gender effect of socioeconomic status on the relationship between marital quality and depression among the older adults, with the intention of providing a practical foundation for enhancing the quality of life of the older adults.MethodsThe data sourced from the third (conducted in 2015, denoted as the first survey) and fourth (carried out in 2018, regarded as the second survey) installments of the China Health and Retirement Longitudinal Survey (CHARLS) were meticulously analyzed through the utilization of cross-lagged analytical techniques and moderating effect examination methodologies.ResultsAmong the older adults, there exists a reciprocal causal relationship between marital quality and the level of depression. Specifically, the marital quality as measured in the first survey was found to significantly prognosticate the depression level in the second survey (β = 0.05, p &lt; 0.05). Conversely, the depression level in the first survey was also demonstrated to significantly forecast the marital quality in the second survey (β = 0.15, p &lt; 0.01). Regarding the moderating role of socioeconomic status, it was observed that among the older adult women, socioeconomic status exerted a moderating influence on the impact of depression on marital quality (β = 0.05, p &lt; 0.05), whereas among the older adult men, their socioeconomic status failed to display a significant moderating effect (β = 0.02, p &gt; 0.05). In a contrasting manner, for the older adult men, the socioeconomic status played a moderating role in the effect of marital quality on depression (β = −0.05, p &lt; 0.01), while for the older adult women, it did not exhibit a moderating effect (β = −0.01, p &gt; 0.05).ConclusionThere exists a reciprocal causal nexus between the marital quality and depression among the older adults. To enhance the life quality of the older adults, it behooves communities and families to proactively focus more on the older adults with subpar marital quality or afflicted by depression, and to disrupt the cyclic interplay between these two variables.
Study on the construction of multi-level protection system for non-emergency transfer under the perspective of structuring
Authors: Liu Wei , Chen Ruiqiang 
Published: January 2025

IntroductionThe non-emergency transfer multi-level protection system is a pivotal livelihood endeavor in China, serving as a vital diversified component within the robust framework of a Chinese-style modern social security system. This system faces various challenges, including displacement of emergency capacity by non-emergency demands, uneven allocation of transfer resources, service quality variations, inadequate management structures, limited regulatory frameworks, and social acceptance issues.MethodsLeveraging structural theory, this study analyzes the primary issues in the current implementation of China’s non-emergency transfer security system. A structured approach is employed to investigate these challenges and propose solutions.ResultsThe study identifies key areas for improvement in the non-emergency transfer security system. It highlights the need for an enhanced internal resource allocation mechanism to boost service efficiency, skilled workforce development to improve service quality, optimized management systems and coordination mechanisms to strengthen patient confidence in recovery, and strengthened comprehensive information technology management for market oversight.DiscussionThe proposed structured approach aims to foster sustainable development of the non-emergency transfer security system within a positive feedback loop. The recommendations aim to address the identified challenges and enhance the overall effectiveness of the system. By improving resource allocation, workforce skills, management systems, and information technology, the study suggests fostering deeper emotional engagement and connections, ultimately contributing to the system’s long-term success.
The relationship between impostor phenomenon and emotional exhaustion among Chinese nurses: the mediating role of bi-directional work-family conflict
Authors: Li Yuan , Qiu Fangxinrui , Luo Biru , Hu Yanling , Li Jie , Li Ying Xin , He Ping , Fang Jinbo 
Published: January 2025

AimsThe study aims to explore the relationship between impostor phenomenon and emotional exhaustion among nurses and to examine the potential mediating role of bi-directional work–family conflict.MethodsA cross-sectional survey using convenience sampling was conducted from January to April 2023, involving 4,088 Chinese nurses. Of those, 3,977 nurses across 43 public hospitals completed the web-based survey that included a sociodemographic information questionnaire, the short Clance Impostor Phenomenon Scale, the Bi-directional Scale of Work–Family Conflict, and the Emotional Exhaustion Scale. SPSS with Hayes’s PROCESS v4.2 Macro was employed to examine the mediation model using bootstrap techniques.ResultsAfter controlling for confounding factors, impostor phenomenon was found to have a direct positive effect on emotional exhaustion (𝛽 = 0.134, 95% CI [0.122 to 0.145]); the two dimensions of work–family conflict, work interfering with family (𝛽 = 0.099, 95% CI [0.090 to 0.109]) and family interfering with work (𝛽 = 0.017, 95% CI [0.012 to 0.022]), served as parallel mediators in the relationship between impostor phenomenon and emotional exhaustion. Compared to family interfering with work, impostor phenomenon had a greater influence on emotional exhaustion through the mediation of work interfering with family, with a difference in the mediating effects of 0.082 (95% CI [0.073 to 0.096]). (The symbol β denotes the regression coefficient, estimated through mediation analysis using a bias-corrected bootstrapping procedure. CI represents the confidence interval for the specified parameter).ConclusionThis study reveals that impostor phenomenon not only directly affects emotional exhaustion but also exerts parallel mediation effects through bi-directional work–family conflict, with work interfering with family exerting a stronger mediating effect than family interfering with work. The findings elucidate the complex interplay between impostor phenomenon, an intrapersonal psychological factor, and work–family conflict, an interpersonal stressor, in contributing to emotional exhaustion among Chinese nurses, providing valuable insights to guide efforts aimed at safeguarding nurses’ mental health and well-being.
Sarcopenia is not associated with hypertension, but sarcopenic obesity increases risk of hypertension: a 7-year cohort study
Authors: Du Runfen , Yuan Junchao , Huang Yunda , Jiang Guihua , Duan Zhiping , Yang Hong , Huang Wei 
Published: January 2025

BackgroundSarcopenia, sarcopenic obesity, and hypertension are all widespread public health problems in middle-aged and older populations, and their association is controversial. The purpose of this study is to analyze the relationship between obesity, sarcopenia, and sarcopenic obesity with hypertension in a middle-aged and older community population in China through a large-scale longitudinal design.MethodsIn this cohort study with 7 years of follow-up, the study population was drawn from participants in the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and followed up in 2013, 2015, and 2018. The diagnostic criteria for sarcopenia were based on the consensus recommendations issued by the Asian Working Group for Sarcopenia (AWGS) in 2019. The diagnosis of obesity is based on body mass index and waist circumference. Sarcopenic obesity is defined as the coexistence of sarcopenia and obesity. Cox proportional risk regression models were used to analyze the association of obesity, sarcopenia, and sarcopenic obesity with hypertension.ResultsA total of 7,301 participants with a mean age of 58 ± 8.8 were enrolled in the study, and 51.9% females. A total of 1,957 participants had a new onset of hypertension after 7 years of follow-up. In a multifactorial analysis, obesity and sarcopenic obesity were associated with hypertension; hazard ratios (HRs) and 95% confidence intervals (CIs) were 1.67 (1.43 ~ 1.96), p &lt; 0.001, and 1.61 (1.09 ~ 2.37), p = 0.017. Sarcopenia and hypertension were not significantly associated; the HR and 95% CI were 1.17 (0.9 ~ 1.52), p = 0.23.ConclusionThere is no significant correlation between sarcopenia and hypertension, but obesity and sarcopenic obesity increase the risk of hypertension. Targeted management of middle-aged and older people with sarcopenic obesity is needed in public health efforts.