bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
Authors: Malik Barizah , Vokic Iva , Mohr Thomas , Poppelaars Marle , Holcmann Martin , Novoszel Philipp , Timelthaler Gerald , Lendl Thomas , Krauss Dana , Elling Ulrich , Mildner Michael , Penninger Josef M , Petzelbauer Peter , Sibilia Maria , Csiszar Agnes 
Published: May 2023

AbstractFAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions. Inducible keratinocyte‐specific ILEI overexpression in mice (K5‐ILEIind) recapitulates many aspects of psoriasis following TPA challenge, primarily manifested by impaired epidermal differentiation and increased neutrophil recruitment. Mechanistically, ILEI triggers Erk and Akt signaling, which then activates STAT3 via Ser727 phosphorylation. Keratinocyte‐specific ILEI deletion ameliorates TPA‐induced skin inflammation. A transcriptomic ILEI signature obtained from the K5‐ILEIind model shows enrichment in several signaling pathways also found in psoriasis and identifies urokinase as a targetable enzyme to counteract ILEI activity. Pharmacological inhibition of urokinase in TPA‐induced K5‐ILEIind mice results in significant improvement of psoriasiform symptoms by reducing ILEI secretion. The ILEI signature distinguishes psoriasis from healthy skin with uPA ranking among the top “separator” genes. Our study identifies ILEI as a key driver in psoriasis, indicates the relevance of ILEI‐regulated genes for disease manifestation, and shows the clinical impact of ILEI and urokinase as novel potential therapeutic targets in psoriasis.
Lectura de textos digitales: ¿nuevas prácticas letradas?
Authors: Godoy Lucía 
Published: May 2023

En el presente artículo se indaga sobre las prácticas de lectura digital en espacios educativos de nivel secundario. Desde el marco de los Nuevos Estudios de la Literacidad, se analizan escenas en aulas de Lengua y Literatura de segundo año nivel secundario las cuales fueron registradas durante un trabajo de campo con perspectiva etnográfica. El propósito del artículo es dar cuenta de las características de las prácticas letradas a fin de analizar cómo son los textos digitales leídos y cómo es la inclusión de las tecnologías digitales en el proceso de lectura. A partir del análisis de las escenas de lectura digital en las aulas, se propone, en primer lugar, una categorización para clasificar a los distintos tipos de textos digitales de acuerdo con sus formas de producción, circulación y permisividades (affordances). En segundo lugar, a partir de las observaciones, se plantea que es necesario ser cautos respecto de los cambios en las prácticas de lectura con tecnologías digitales, ya que no siempre que se incorporan las tecnologías digitales cabe hablar de nuevas prácticas letradas y literacidades, sino solamente de nuevos soportes. Por esta razón, el carácter innovador de las prácticas letradas dependerá de las actividades y saberes que se expresen en las aulas.
Sodium Bicarbonate Treatment and Vascular Function in CKD: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Kendrick Jessica , You Zhiying , Andrews Emily , Farmer-Bailey Heather , Moreau Kerrie , Chonchol Michel , Steele Cortney , Wang Wei , Nowak Kristen L. , Patel Nayana 
Published: May 2023

Significance Statement
Lower serum bicarbonate levels, even within the normal range, are strongly linked to risks of cardiovascular disease in CKD, possibly by modifying vascular function. In this randomized, controlled trial, treatment with sodium bicarbonate (NaHCO3) did not improve vascular endothelial function or reduce arterial stiffness in participants with CKD stage 3b–4 with normal serum bicarbonate levels. In addition, NaHCO3 treatment did not reduce left ventricular mass index. NaHCO3 did increase plasma bicarbonate levels and urinary citrate excretion and reduce urinary ammonium excretion, indicating that the intervention was indeed effective. NaHCO3 therapy was safe with no significant changes in BP, weight, or edema. These results do not support the use of NaHCO3 for vascular dysfunction in participants with CKD.

Background
Lower serum bicarbonate levels, even within the normal range, are strongly linked to risks of cardiovascular disease in CKD, possibly by modifying vascular function. Prospective interventional trials with sodium bicarbonate (NaHCO3) are lacking.

Methods
We conducted a randomized, double-blind, placebo-controlled trial examining the effect of NaHCO3 on vascular function in 109 patients with CKD stage 3b–4 (eGFR 15–44 ml/min per 1.73 m2) with normal serum bicarbonate levels (22–27 mEq/L). Participants were randomized 1:1 to NaHCO3 or placebo at a dose of 0.5 mEq/lean body weight-kg per day for 12 months. The coprimary end points were change in brachial artery flow-mediated dilation (FMD) and change in aortic pulse wave velocity over 12 months.

Results
Ninety patients completed this study. After 12 months, plasma bicarbonate levels increased significantly in the NaHCO3 group compared with placebo (mean [SD] difference between groups 1.35±2.1, P = 0.003). NaHCO3 treatment did not result in a significant improvement in aortic pulse wave velocity from baseline. NaHCO3 did result in a significant increase in flow-mediated dilation after 1 month; however, this effect disappeared at 6 and 12 months. NaHCO3 resulted in a significant increase in 24-hour urine citrate and pH and a significant decrease in 24-hour urine ammonia. There was no significant change in left ventricular mass index, ejection fraction, or eGFR with NaHCO3. NaHCO3 treatment was safe and well-tolerated with no significant changes in BP, antihypertensive medication, weight, plasma calcium, or potassium levels.

Conclusion
Our results do not support the use of NaHCO3 for vascular dysfunction in participants with CKD and normal serum bicarbonate levels.
Should Infants with Blunt Traumatic Brain Injuries and Intracranial Hemorrhage Have Routine Repeat Imaging?
Authors: Engel E. Patricia , Bitter Bradon , Reyes Jared , Grundmeyer Raymond , Helmer Stephen , Haan James M 
Published: May 2023

Introduction. The practice of repeat head CT imaging in infants as a distinct population is poorly studied. The purpose of this study was to evaluate the incidence and utility of repeat head CT in the infant population.
Methods. A 10-year retrospective review was conducted of infants with blunt traumatic head injuries (N = 50) that presented to a trauma center. Information from the hospital trauma registry and patient medical records were extracted regarding the size and type of injury, number and results of computed tomography (CT) imaging, changes in neurological exams, and any interventions that were required.
Results. Most patients (68%) had at least one repeat CT, with 26% showing progression of hemorrhage. Decreased GCS was associated with having repeat CT scans. Nearly one in four infants had a change in management associated with repeat imaging. Repeat CT scans resulted in operative interventions in 11.8% of cases and longer ICU stays in 8.8% of cases. Repeat CT scans were associated with increased hospital length of stay, but not with increased ventilator days, ICU length of stay, or mortality. Worsening bleeds were associated with mortality, but not with other hospital outcomes.
Conclusions. Changes in management following repeat CT appear to be more common in this population than in older children or adults. Findings from this study support repeat CT imaging in infants, however, further research is needed to validate results of this study.
Deep Learning-Based Automated Detection of Lung Cancer from CT Scans: A Comparative Study
Authors: Negi Charu 
Published: May 2023

ABSTRACT
Lung cancer is one of the leading causes of death resulting from the disease on a global scale. In order to provide effective therapy and achieve better outcomes for patients, early detection and diagnosis are essential. Deep learning (DL) algorithms have demonstrated significant promise in recent years for their use in medical imaging analysis, particularly in the detection and diagnosis of lung cancer. This paper includes a comparative comparison of a number of different DL based models for the automated diagnosis of lung cancer from computed tomography (CT) data.
Real Time Spatial Transmission Analysis Based Improved Black Hole Attack Detection In WSN For Improved QoS
Authors: Bhatt Neha 
Published: May 2023

ABSTRACT
Despite the extensive utilisation of Wireless Sensor Networks (WSNs), they remain vulnerable to various types of security breaches, including black hole attacks. The detection and prevention of black hole attacks are crucial for safeguarding the security and reliability of Wireless Sensor Networks (WSNs). The present study introduces a technique for real-time detection of black hole attacks in Wireless Sensor Networks (WSNs) by means of spatial transmission analysis, with the aim of enhancing Quality of Service (QoS). In order to enhance the identification of black hole attacks, we propose a methodology that leverages real-time spatial transmission analysis to quantify the Euclidean distance separating the source and destination nodes of every packet. An algorithm with a high detection rate and a low false positive rate was developed by us. In order to evaluate the efficacy of the proposed mechanism and establish a comparative analysis with existing methodologies, we conducted extensive experimentation. The results indicate that the proposed mechanism exhibits superior performance compared to existing techniques in terms of both detection rate and false positive rate. Our proposed mechanism aims to safeguard the quality of service of Wireless Sensor Networks (WSNs) against black hole attacks in real-time.
Sparse Gradient Regularized Deep Retinex Network for Robust Low-Light Image Enhancement
Authors: Taluja Resham 
Published: May 2023

An algorithm for improving images was created in this procedure. It is founded on the linear domain simultaneous estimate of light and reflectance. For single picture low-light enhancement, many image priors have been used. However, the most effective technique is to evenly enhance the illumination directly. By extending the dynamic pixel intensity of a picture, histogram equalisation (HE) can solve the issue of lighting and make dark images visible. Instead than changing the lighting, HE seeks to improve the contrast. As a result, the findings are resilient to noise and improve image quality. The test findings demonstrate the good performance of the suggested approach to provide lighting and reflectance with increased visual outcomes and a promising convergence rate. The suggested technique produces equivalent or superior outcomes in subjective as well as objective evaluations when compared to previous testing methodologies. Image enhancement’s main goal is to treat an input image such that the final output is more suitable for a certain application than the original image. It draws attention to or emphasises visual elements like borders, limits, or contrast to make a graphic presentation more useful for study and display. The improvement enhances the dynamic range of the selected characteristics, making it easier to recognise them even while it does not increase the data's intrinsic information richness.
Annelerde Postpartum Depresyon, Sosyal Destek ve Emzirme Öz Yeterliliği Arasındaki İlişkinin İncelenmesi
Authors: ÇINAR Nursan , TOPAL Sümeyra , YALNIZOĞLU ÇAKA Sinem , ALTINKAYNAK Sevin 
Published: May 2023

Amaç: Bu çalışmanın amacı, annelerde postpartum depresyon, sosyal destek ve emzirme öz yeterliliği arasındaki ilişkiyi belirlemektir.
Gereç ve Yöntem: Tanımlayıcı ve kesitsel desende gerçekleştirilen çalışma, doğumundan sonraki 2 hafta- 4 ay içerisindeki 155 anne ile yürütülmüştür. Veriler, Soru Formu, Çok Boyutlu Algılanan Sosyal Destek Ölçeği (ÇBASDÖ), Edinburgh Doğum Sonrası Depresyon Ölçeği (EDSDÖ) ve Emzirme Öz Yeterlilik Ölçeğinin kısa formu (EÖYÖ) kullanılarak toplandı.
Bulgular: Katılımcıların yaş ortalaması 27.21±5.48 idi. Araştırmaya katılan annelerin çeşitli tanıtıcı özellikleri ile ölçekler arasında anlamlı ilişki olduğu saptandı. EDSDÖ kesme puanı 13 alındığında, %33.5’inin ölçekten aldıkları puan ortalaması 16.67±2.90 ile kesme puanının altında kaldıkları (depresyon var), %66.5’inin puan ortalaması ise 6.72±2.93 ile kesme puanının üstünde oldukları ve aradaki bu farkın anlamlı olduğu görüldü (Z=-10.171; p
Three-dimensional morphometric analysis of maxillary and mandibular molars and bilateral correlation in North Indian population
Authors: Nikhil Vineeta , Gupta Swati , Bhalla Khushboo , Sahu Sonal 
Published: May 2023

The aim of this study was to evaluate and compare the anatomical landmarks of maxillary and mandibular molar pulp chambers and evaluate bilateral symmetry between contralateral molars using CBCT.CBCT scans of 200 molars from 157 patients were selected for the study. A total of nine measurements - A (Distance from the cusp tip to the roof of the pulp chamber) B (Distance from the cusp tip to the floor of the pulp chamber) C (Distance from the cusp tip to the furcation) D (Distance from the floor of the pulp chamber to the furcation) E (Distance from the roof of the pulp chamber to the furcation) F (Height of pulp chamber) A1(Distance from the central fossa to the roof of the pulp chamber) B1 (Distance from central fossa till the floor of pulp chamber) C1 (Distance from central fossa to furcation) were done. Statistical analysis was done using the ANOVA and Post hoc tests and statistical significance was set at p&#60;0.05. Significant differences in maxillary and mandibular molars were noted in the measurements of- D, E, B and C1. Bilateral symmetry was also observed between the pairs of maxillary and mandibular molars.Maxillary first and second molars do not differ much from each other. However, mandibular first and second molars differed in various anatomic parameters from each other. Contralateral molars (maxillary and mandibular) pulp cavities, in general, exhibit matching symmetry in terms of their morphological and anatomical landmarks.
Potensi Konflik atas Berlakunya Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja
Authors: Yunani Yunani , Akhyar Taufik , Apriani Reni 
Published: May 2023

ABSTRAK
Penelitian ini berjudul “Potensi Konflik Atas Berlakunya Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja (Studi Pada Serikat Pekerja Buruh Di Kota Palembang). Tujuan dari penelitian yaitu untuk mengetahui potensi konflik atas berlakunya undang-undang nomor 11 tahun 2020 tentang cipta kerja di kota palembang. Metode penelitian yang digunakan adalah deskriptif kualitatif. Teknik pengumpulan data adalah dengan wawancara dan dokumentasi. Sumber data primer dari penelitian melalui wawancara dengan kantor Dewan Pengurus Cabang Federasi Serikat Buruh (DPC FSB NIKEUBA) Kota Palembang. Hasil dari penelitian adalah atas berlakunya undang-undang No 11 tahun 2020 tentang cipta kerja ini ternyata menimbulkan konflik bagi pekerja buruh dan juga sangat merugikan bagi pekerja buruh. Sehingga status undang-undang cipta kerja tersebut sekarang inskonstitusional bersyarat, akan tetapi jika ingin menjadi konstitusional maka harus diperbaiki dalam jangka dua tahun. Tetapi jika dalam jangka dua tahun tidak ada perbaikan maka menjadi inskonstitusional permanen artinya batal demi hukum undang-undang tersebut.
Kata Kunci : Potensi, Konflik, Undang-undang Tentang Cipta Kerja, Buruh
Pencegahan Kecurangan oleh Bawaslu pada Pemungutan Suara Pemilu
Authors: Pramana Andri , Ropik Ainur , Darmawan Erik 
Published: May 2023

ABSTRAK
Peneletian ini membahas tentang Pencegahan Kecurangan Oleh Bawaslu Pada Pemungutan Suara Ulang PSU Pilkada Kabupaten Pali Tahun 2020. Tujuan penelitian ini adalah untuk mengetahui pelaksanaan Pencegahan Kecurangan Oleh Bawaslu Pada Pemungutan Suara Ulang PSU Pilkada Kabupaten Pali dan Untuk mengetahui faktor penghambat dan pendukung Bawaslu dalam melakukan Pencegahan Kecurangan pada PSU Pilkada Kabupaten Pali Tahun 2020. Objek dalam penelitian ini adalah Bawaslu Kabupaten Pali. Teori yang di Gunakan adalah Teori Pemilu untuk menganalisa Pencegahan Kecurangan Oleh Bawaslu Pada PSU Kabupaten Pali. Metode yang digunakan dalam penelitian ini adalah deskriftif dengan metode Kualitatif. Sumber data dalam penelitian adalah Koordinator Divisi Penanganan dan Pelangaran Sengketa Pemilu dan Masyarakat. Data di kumpulkan dan dianalisa melalui dokumentasi dan wawancara. Hasil penelitian ini Bawaslu telah melakukan pencegahan kecurangan pada pelaksanaan PSU dengan melakukan pergantian petugas KPPS, pendataan ulang daftar pemilih tetap atau DPT, himbauan untuk tidak money politik, himbauan untuk tidak golput, serta dengan faktor penghamabat kurangan kesadaran masyarakat, keterbatasan waktu penyelengaraan PSU, kuranya Sumber daya Manusia, SDM dan di dukung oleh Bawaslu Pusat, Provinsi, dan Sentra Gakkumdu yang terdiri Kepolisian, Kejaksaan, dan Bawaslu.
Kata Kunci : Pencegahan Kecurangan, Bawaslu Kabupaten Pali, PSU
Relation between Hypertension Knowledge and Behavior with Blood Pressure on Hypertensive Farm Workers in Mumbulsari Public Health Center Working Area
Authors: Alyssandra Afqorina Agung  , Yuli Hermansyah  , Angga Mardro Raharjo  , Jauhar Firdaus  , Pipiet Wulandari  
Published: May 2023

The prevalence of hypertension in Indonesia is still relatively high. One of them is hypertension experienced by people who work as farm workers. The high prevalence of hypertension can be caused by the lack of knowledge and behavior of farm workers regarding hypertension. Knowledge about hypertension affects the formation of hypertension control behavior so that it has an impact on blood pressure values. The purpose of this study was to determine the relationship between knowledge and behavior about hypertension with the blood pressure of hypertensive farm workers in the work area of the Mumbulsari Jember Health Center. This study used subjects of agricultural workers who had hypertension in the working area of the Mumbulsari Jember Health Center. The study was conducted by measuring the subject's knowledge about hypertension using the Hypertension Knowledge-Level Scale (HK-LS) questionnaire, the subject's behavior regarding hypertension using the High Blood Pressure – Self Care Profile – Behavior Scale (HBP-SCP-BS) questionnaire, and blood pressure using a digital sphygmomanometer. The results of the study obtained included the majority of subjects had knowledge with sufficient category of 61.90%, behavior with sufficient category of 57.14%, and blood pressure with stage 1 hypertension category of 47.61%. Bivariate analysis with the Mann-Whitney test did not show a significant association between knowledge and blood pressure, but there was a significant relationship between behavior and blood pressure.
Artificial Intelligence Uncovers Evolutionarily Conserved Intracellular Allosteric Modulators of GPCR-Gα Interface
Authors: Mohanty Sanjay , Mittal Aayushi , Gaur Aakash , Solanki Saveena , Kumar Suvendu , Duari Subhadeep , Arora Sakshi , Gautam Vishakha , Dixit Nilesh , Ghosh Tarini , Sengupta Debarka , Gupta Shashi , Murugan Natarajan , Ahuja Gaurav 
Published: May 2023

Abstract
Traditionally, the exogenous allosteric modulators of G protein-coupled receptors (GPCRs) have been extensively investigated due to their pharmacological significance. However, to date, only a handful of endogenous intracellular allosteric modulators are known, that too with inconclusive binding information and their associated phenotypes. This limitation primarily stems from the non-availability of robust computational techniques that entails unbiased cavity identification across GPCR protein topology, cavity-specific ligand design, their synthesis, and cross-validation. Here, we introduce Gcoupler, which leverages an integrative approach combining de novo ligand design, statistical methods, and Graph Neural Networks for rationally predicting high-affinity ligands. Gcoupler offers an efficient and comparatively faster route to explore endogenous allosteric sites of GPCRs, including the GPCR-Gα interface. We tested and validated the applicability of Gcoupler in decrypting the cellular metabolites that could intracellularly but directly modulate the Ste2 (GPCR)-mediated pheromone-induced cell death in yeast. Our rigorous interrogation using Gcoupler and experimental approaches, including yeast genetic screening, RNA Sequencing, high-resolution metabolomics, and functional assays, identified endogenous hydrophobic metabolites as intracellular allosteric inhibitors of Ste2p signaling. Elevated intracellular levels of these metabolites, either naturally, through genetic alterations, or exogenous treatment, rescue the pheromone-induced programmed cell death. Mechanistic insights revealed that metabolites harbor high-binding affinity to the conserved GPCR-Gα interface and trigger a cohesive response that potentially obstructs downstream signaling. Finally, by utilizing isoproterenol-induced, GPCR-mediated human and neonatal rat cardiac hypertrophy models, we observed that elevated metabolite levels attenuate hypertrophic response, reinforcing the functional and evolutionary relevance of this mechanism. In summary, our study reports a robust computational method that uncovered a novel, evolutionary conserved, and metabolite-driven regulatory mechanism of GPCR signaling.
Alksite – based material to restore endodontically treated teeth: A randomized controlled clinical trial
Authors: Bepu Davi , Franco Natalia , Souza-Gabriel Aline , Sanchez Luiza Pejon , Corona Silmara 
Published: May 2023

Abstract
Objectives The aim of this study was evaluated longitudinally evaluate, after a 6-months period, the clinical performance of an alkasit- based material (Cention N, Ivoclar) in molars with root canal treatment.
Methods The project was registered in the Brazilian Registry of Clinical Trials – REBEC (RBR97kx5jv) on 19/01/2023. This randomized clinical trial that included 33 patients with an endodontically treated mandibular molar requiring restoration. Patients were randomly assigned according to the restorative treatment: control: restoration with Bulk-fill resin (Ivoclar - n=17) and restoration with alkasite-based material (Ivoclar - n=16). A self-etching adhesive was applied. Three calibrated professionals used the United States Public Health Service (USPHS) criteria to evaluate retention, secondary caries, marginal adaptation, restoration color, marginal pigmentation, and anatomical shape at seven days(baseline) and six months. The radiographic analysis assessed the presence of a radiolucent line adjacent to the restoration, the lack or excess of the material, contact point, and caries recurrence in both periods. Data were analyzed by Friedman, Kruskall-Walis, and Wilcoxon tests (α=0.05).
Results After 6 months of follow up, the Alksite-based demonstrated greater wear of the anatomical shape (p=0.022), and a greater color difference compared to natural tooth (p=0.0332), both with a statistically significant difference. All other criteria did not show significant differences between the materials or the analysis periods.
Conclusion The use of Alkasite-based material on endodontically treated teeth influenced the color and anatomical shape performance, however did not influence the longevity and success of the composite restorations after six months. Clinical Relevance Alkasite Based material may be an alternative for the restoration of endodontically treated teeth