bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis
Authors: Papadopoulou Alexandra , Amil‐Dias Jorge , Auth Marcus Karl‐Heinz , Chehade Mirna , Collins Margaret H. , Gupta Sandeep K. , Gutiérrez‐Junquera Carolina , Orel Rok , Vieira Mario C. , Zevit Noam , Atkins Dan , Bredenoord Albert J. , Carneiro Fatima , Dellon Evan S. , Gonsalves Nirmala , Menard‐Katcher Calies , Koletzko Sibylle , Liacouras Chris , Marderfeld Luba , Oliva Salvatore , Ohtsuka Yoshikazu , Rothenberg Marc E. , Strauman Alex , Thapar Nikhil , Yang Guan‐Yu , Furuta Glenn T. 
Published: July 2023

IntroductionEosinophilic gastrointestinal disorders beyond eosinophilic esophagitis (non‐EoE EGIDs) are rare chronic inflammatory disorders of the gastrointestinal (GI) tract. Diagnosis is based on clinical symptoms and histologic findings of eosinophilic inflammation after exclusion of a secondary cause or systemic disease. Currently, no guidelines exist for the evaluation of non‐EoE EGIDs. Therefore, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) formed a task force group to provide consensus guidelines for childhood non‐EoE EGIDs.MethodsThe working group was composed of pediatric gastroenterologists, adult gastroenterologists, allergists/immunologists, and pathologists. An extensive electronic literature search of the MEDLINE, EMBASE, and Cochrane databases was conducted up to February 2022. General methodology was used in the formulation of recommendations according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to meet current standards of evidence assessment.ResultsThe guidelines provide information on the current concept of non‐EoE EGIDs, disease pathogenesis, epidemiology, clinical manifestations, diagnostic and disease surveillance procedures, and current treatment options. Thirty‐four statements based on available evidence and 41 recommendations based on expert opinion and best clinical practices were developed.ConclusionNon‐EoE EGIDs literature is limited in scope and depth, making clear recommendations difficult. These consensus‐based clinical practice guidelines are intended to assist clinicians caring for children affected by non‐EoE EGIDs and to facilitate high‐quality randomized controlled trials of various treatment modalities using standardized, uniform disease definitions.
Intergenerational Trauma, Dependency, and Detachment
Authors: Spiel Shira , Szymanski Kate , Bornstein Robert 
Published: July 2023

Abstract
The literature on intergenerational transmission of trauma is predominantly focused on the mental health functioning of children and grandchildren of trauma survivors. Research shows that having a traumatized parent is related to increased psychopathology and dysfunctional attachment patterns in the next generation, but little is known about the effects of parental trauma on other aspects of interpersonal relating. The current study addresses this gap. Participants were young adult students from an urban college; individual and parental trauma histories, and indices of unhealthy dependency, dysfunctional detachment, and healthy dependency, were obtained. Results indicated that a wide range of parental traumas were positively correlated with dysfunctional detachment, but not related to destructive overdependence or healthy dependency. These results suggest that a wide range of parental traumas have a negative impact on the next generation's interpersonal dependency by fostering a tendency to distance themselves from close relationships.
Affective Temperaments in Differentiation Between Melancholic and Nonmelancholic Depression: A Case-Control Study
Authors: Tamada Yu , Inoue Takeshi , Sekine Atsushi , Toda Hiroyuki , Takeshima Minoru , Sasaki Masaaki , Fujimura Yota , Ohmae Susumu 
Published: July 2023

Abstract
The association between major depressive disorder (MDD) and personality traits has been extensively studied. However, differences in personality traits between patients with melancholic MDD (MEL) and nonmelancholic MDD (NMEL) remain unclear. In this study, we aimed to determine whether neuroticism, which has been associated with MDD, and the five affective temperament subtypes assessed by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) can be used to distinguish MEL and NMEL. A total of 106 patients with MDD (MEL, n = 52; NMEL, n = 54) and 212 age- and sex-matched healthy controls answered the Eysenck Personality Questionnaire-revised and the short version of TEMPS-A. In hierarchical logistic regression analysis, only depressive temperament scores were identified as a statistically significant feature distinguishing NMEL from MEL. Depressive temperament scores assessed by the short version of TEMPS-A were found to be significantly higher in NMEL patients than in MEL patients.
Prior COVID-19 Infection Predisposes to Worse Outcomes After Autologous Breast Reconstruction
Authors: Karius Alexander K. , Chen Jonlin , Tiongco Rafael Felix P. , Lagziel Tomer , Cooney Carisa M. , Broderick Kristen P. 
Published: July 2023

BackgroundMajor shifts in health care systems worldwide have occurred because of coronavirus disease 2019 (COVID-19). With nearly half of all Americans now having a history of COVID-19 infection, there is a pressing need to better understand the importance of prior COVID-19 infection as a potential surgical risk factor. The aim of this study was to investigate the impact of a history of prior COVID-19 infection on patient outcomes after autologous breast reconstruction.MethodsWe performed a retrospective study using the TriNetX research database, which contains deidentified patient records from 58 participating international health care organizations. All patients who underwent autologous breast reconstruction between March 1, 2020, and April 9, 2022, were included and were grouped based on history of a prior COVID-19 infection. Demographic, preoperative risk factors, and 90-day postoperative complication data were compared. Data were analyzed by propensity score–matched analysis on TriNetX. Statistical analyses were performed by Fisher exact, χ2, and Mann-WhitneyUtests as appropriate. Significance was set atPvalues of <0.05.ResultsPatients with a history of autologous breast reconstruction within our temporal study window (N = 3215) were divided into groups with (n = 281) and without (n = 3603) a prior COVID-19 diagnosis. Nonmatched patients with prior COVID-19 had increased rates of select 90-day postoperative complications, including wound dehiscence, contour deformities, thrombotic events, any surgical site complications, and any complications overall. Use of anticoagulant, antimicrobial, and opioid medications was also found to be higher in those with prior COVID-19.After performing propensity-score matching, each cohort consisted of 281 patients without statistically significant differences between any baseline characteristics. When comparing outcomes between matched cohorts, patients with a history of COVID-19 had increased rates of wound dehiscence (odds ratio [OR], 1.90;P= 0.030), thrombotic events (OR, 2.83;P= 0.0031), and any complications (OR, 1.52;P= 0.037).ConclusionsOur results suggest that prior COVID-19 infection is a significant risk factor for adverse outcomes after autologous breast reconstruction. Patients with a history of COVID-19 have 183% higher odds of postoperative thromboembolic events, warranting careful patient selection and postoperative management.
Orbitalization of Ethmoidal Sinus With Stacked Cross-linked Acellular Dermal Matrix: A New Strategy to Reconstruct Medial Orbital Wall Fracture
Authors: Park Tae Hwan 
Published: July 2023

Background:
The use of an acellular dermal matrix (ADM) has not been reported in medial orbital wall fracture reconstruction previously. This study aimed to share our early experience with the cross-linked ADM as an allograft material for medial orbital wall reconstruction.

Methods:
In this study, the author evaluated the medical records and serial facial computed tomography scans of 27 patients with pure medial orbital wall fractures reconstructed by a single surgeon between May 2021 and March 2023. The author routinely approached the medial orbital wall with a retrocaruncular incision. Five out of 27 patients were reconstructed with trimmed, multiple folded, 1.0-mm-thick cross-linked ADM (MegaDerm; L&C Bio, South Korea).

Results:
All cases reconstructed with cross-linked ADM improved clinically and radiologically without complications. The serial computed tomography findings revealed that implanted cross-linked ADM successfully covered the defect while providing a significant volumizing effect.

Conclusions:
This is the first study to show the efficacy of cross-linked ADM for orbital medial wall fracture reconstruction. Our strategy of orbitalization of ethmoidal sinus with stacked cross-linked ADM would be an excellent surgical option.
A Cone Beam Computed Tomography Analysis of Bone Volume Variations of Extra-alveolar Region Based on Sex, Age, Vertical and Sagittal Facial Patterns
Authors: Ling Chuanliang , Shen Yuqing , Zhang Xian , Ding Xiaojun 
Published: July 2023

Objectives:
The goal of this study is to measure mandibular buccal shelf (MBS) concerning angulation, bone volume, and cortical bone volume as well as bone depth and cortical bone depth of infrazygomatic crest (IZC) via cone beam computed tomography and evaluate the measurements according to sex, age, vertical, and sagittal facial types.

Materials and Methods:
This study collected lateral cephalograms and cone beam computed tomography scans from 100 individuals, which were used to observe angulation, bone and cortical bone volume entailing width and depth of MBS as well as the depth of IZC. FH-MP (mandibular plane angle) and A point-Nasion-B point were adopted to determine vertical and sagittal facial patterns respectively.

Results:
Bone widths at 6 mm and 11 mm to cementoenamel junction (CEJ) and cortical bone width at 6 mm to CEJ in MBS showed significant sex differences, while bone depths and cortical bone depths in IZC show significant age difference(P<0.05). Bone width and cortical bone width at 6 mm to CEJ at the mesial root and 11 mm to CEJ at both roots as well as angulations of MBS in the mandibular first molar region, bone depth and cortical bone depth at the maxillary first molar distal buccal root, and the proximity region were all correlated to FH-MP (P<0.05).

Conclusions:
Short-faced individuals of Asian ethnicity tend to have greater bone width, greater projection in MBS, and greater bone depth in the posterior region of IZC. The optimal implant sites are 11 mm apical to CEJ at the mandibular second molar distal root and 65° at the maxillary first molar mesial root.
Donor Safety and Risk Factors of Pure Laparoscopic Living Donor Right Hepatectomy
Authors: Kim Sang-Hoon , Kim Ki-Hun , Cho Hwui-Dong , Suh Kyung-Suk , Hong Suk Kyun , Lee Kwang-Woong , Choi Gyu-Seong , Kim Jong Man , Choon Hyuck David Kwon , Cho Jai Young , Han Ho-Seong , Han Jaryung , Han Young Seok 
Published: July 2023

Background:
Pure laparoscopic donor right hepatectomy (PLDRH) is not yet a standardized surgical procedure due to lack of data.

Objective:
The aim was to identify safety and risk factors of living donor after PLRDH in a Korean multicenter cohort study.

Methods:
This retrospective study included 543 patients undergoing PLRDH between 2010 and 2018 in five Korean transplantation centers. Complication rates were assessed and multivariate logistic regression analyses were performed to identify risk factors of open conversion, overall complications, major complications, and biliary complications.

Results:
Regarding open conversion, the incidence was 1.7% and the risk factor was body mass index (BMI) >30 kg/m2 (P=0.001, odds ratio [OR] 22.72, 95% confidence interval [CI] 3.56–146.39). Rates of overall, major (Clavien-Dindo classification III-IV), and biliary complications were 9.2%, 4.4%, and 3.5%, respectively. For overall complications, risk factors were graft weight >700 g (P=0.007, OR 2.66, 95% CI 1.31–5.41), estimated blood loss (P<0.001, OR 4.84, 95% CI 2.50–9.38), and operation time >400 minutes (P=0.01, OR 2.46, 95% CI 1.25–4.88). For major complications, risk factors were graft weight >700 g (P=0.002, OR 4.01, 95% CI 1.67–9.62) and operation time >400 minutes (P=0.003, OR 3.84, 95% CI 1.60–9.21). For biliary complications, risk factors were graft weight >700 g (P=0.01, OR 4.34, 95% CI 1.40–13.45) and operation time >400 minutes (P=0.01, OR 4.16, 95% CI 1.34–12.88).

Conclusions:
Careful donor selection for PLRDH considering BMI, graft weight, estimated blood loss, and operation time combined with skilled procedure can improve donor safety.
Outcomes of Elective and Non-elective Fenestrated-branched Endovascular Aortic Repair for Treatment of Thoracoabdominal Aortic Aneurysms
Authors: Dias-Neto Marina , Vacirca Andrea , Huang Ying , Baghbani-Oskouei Aidin , Jakimowicz Tomasz , Mendes Bernardo C. , Kolbel Tilo , Sobocinski Jonathan , Bertoglio Luca , Mees Barend , Gargiulo Mauro , Dias Nuno , Schanzer Andres , Gasper Warren , Beck Adam W. , Farber Mark A. , Mani Kevin , Timaran Carlos , Schneider Darren B. , Pedro Luis Mendes , Tsilimparis Nikolaos , Haulon Stéphan , Sweet Matthew P. , Ferreira Emília , Eagleton Matthew , Yeung Kak Khee , Khashram Manar , Jama Katarzyna , Panuccio Giuseppe , Rohlffs Fiona , Mesnard Thomas , Chiesa Roberto , Kahlberg Andrea , Schurink Geert Willem , Lemmens Charlotte , Gallitto Enrico , Faggioli Gianluca , Karelis Angelos , Parodi Ezequiel , Gomes Vivian , Wanhainen Anders , Habib Mohammed , Colon Jesus Porras , Pavarino Felipe , Baig Mirza S. , Gouveia e Melo Ryan Eduardo Costeloe De , Crawford Sean , Zettervall Sara L. , Garcia Rita , Ribeiro Tiago , Alves Gonçalo , Gonçalves Frederico Bastos , Kappe Kaj Olav , Mariko van Knippenberg Samira Elize , Tran Bich Lan , Gormley Sinead , Oderich Gustavo S. ,   On behalf of The International Multicenter Aortic Research Group
Published: July 2023

Objective:
To describe outcomes after elective and non-elective fenestrated-branched endovascular aortic repair (FB-EVAR) for thoracoabdominal aortic aneurysms (TAAAs).

Background:
FB-EVAR has been increasingly utilized to treat TAAAs; however, outcomes after non-elective versus elective repair are not well described.

Methods:
Clinical data of consecutive patients undergoing FB-EVAR for TAAAs at 24 centers (2006–2021) were reviewed. Endpoints including early mortality and major adverse events (MAEs), all-cause mortality, and aortic-related mortality (ARM), were analyzed and compared in patients who had non-elective versus elective repair.

Results:
A total of 2603 patients (69% males; mean age 72±10 year old) underwent FB-EVAR for TAAAs. Elective repair was performed in 2187 patients (84%) and non-elective repair in 416 patients [16%; 268 (64%) symptomatic, 148 (36%) ruptured]. Non-elective FB-EVAR was associated with higher early mortality (17% vs 5%, P<0.001) and rates of MAEs (34% vs 20%, P<0.001). Median follow-up was 15 months (interquartile range, 7–37 months). Survival and cumulative incidence of ARM at 3 years were both lower for non-elective versus elective patients (50±4% vs 70±1% and 21±3% vs 7±1%, P<0.001). On multivariable analysis, non-elective repair was associated with increased risk of all-cause mortality (hazard ratio, 1.92; 95% CI] 1.50–2.44; P<0.001) and ARM (hazard ratio, 2.43; 95% CI, 1.63–3.62; P<0.001).

Conclusions:
Non-elective FB-EVAR of symptomatic or ruptured TAAAs is feasible, but carries higher incidence of early MAEs and increased all-cause mortality and ARM than elective repair. Long-term follow-up is warranted to justify the treatment.
Monitoring the battleground: Exploring Antimicrobial Resistance, Antibiofilm Trends, and Virulence Factors in Wound Bacterial Isolates.
Authors: Awuor Silas Onyango , Omwenga Eric O. , Mariita Richard M. , Musila Jonathan , Musyoki Stanslaus 
Published: July 2023

There is an alarming increase in antibiotic resistance especially on common bacterial infections that could be attributed to extensive unregulated use of antibiotics. Continuous strategic monitoring of antibiotic use and AMR trends becomes imperative. This serves as a motivation to a thorough evaluation of wound isolates for relevant bacteria and assessing their drug susceptibility patterns, which we report herein. This cross-sectional study aimed to decipher antibacterial resistance by examining samples collected from patients with chronic wounds seeking medication at Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH). Standard microbiological methods were employed to identify and characterize the bacterial pathogens. Analysis of the wound isolates revealed a significant presence of microbial growth, with a higher prevalence of59% isolates in male patients. Staphylococcus aureus 20.7%emerged as the most predominant pathogen, followed by Klebsiella spp.14.8%, P. aeruginosa spp. 14.8%, and E. coli 4.4% in the wound samples. Notably, Cotrimoxazole exhibited the highest antibacterial resistance 48.1%, followed by Clindamycin 25.9% and Erythromycin 25.9%, affecting both Gram-positive and Gram-negative bacteria. Furthermore, among the isolates, 75% were capable of producing haemolysin and protease, while 50% produced lipase and phospholipase, factors that enhance virulence and survival. These findings provide crucial insights into antimicrobial resistance in chronic wounds, emphasizing the importance of responsible antibacterial use in wound management. Additionally, they shed light on the need for developing more potent antibiotics for effectively treating chronic wounds.
Unraveling the Molecular Landscape of Congenital Pseudoarthrosis of the Tibia: Insights from a Comprehensive Analysis of 162 Probands
Authors: Zhu Guanghui , Li Nan , Zheng Yu , Wang Shunyao , Yang Ge , Liu Yaoxi , Xu Zongren , Huang Hui , Peng Huanhuan , Mei Haibo 
Published: July 2023

AbstractCongenital pseudarthrosis of the tibia (CPT, HP:0009736), commonly known as bowing of the tibia, is a rare congenital tibia malformation characterized by spontaneous tibial fractures and the difficulty of reunion after tibial fractures during early childhood, with a very low prevalence between 1/250,000∼1/140,000. While 80%–84% of CPT cases present with neurofibromatosis type 1, caused by the mutations inNF1, the underlying cause of CPT is still unclear. Considering the congenital nature and the low prevalence of CPT, we hypothesized that the rare genomic mutations may contribute to CPT. In this study, we conducted whole exome sequencing on 159 patients with CPT and full-length transcriptome sequencing on an additional 3 patients with CPT. The data analysis showed there were 179 significantly up-regulated genes which were enriched in 40 biological processes among which 21 biological processes hold their loss of function (LoF) excesses between 159 cases against 208 controls from 1000 Genomes Project. From those 21 biological processes with LoF excesses, there were 259 LoF-carried genes among which 40 genes with 56 LoF variations in 63 patients were enriched in osteoclast differentiation pathway (hsa04380) with its 3 directly regulated pathways including MAPK signaling pathway (hsa04010), calcium signaling pathway (hsa04020) and PI3K-Akt signaling pathway (hsa04151), as well as fluid shear stress and atherosclerosis pathway (hsa05418) while 12 patients carried 9 LoF variations in theNF1gene. The rare LoF variations in these pathways accounted for ∼39.6% of this CPT cohort. These findings shed light on the novel genetic mutations and molecular pathways involved in CPT, providing a new framework for understanding how the genetic variations regulate the biological processes in the pathology of CPT and indicating potential next directions to further elucidate the pathogenesis of CPT.
The draft genome of the microscopicNemertoderma westbladisheds light on the evolution of Acoelomorpha genomes
Authors: Abalde Samuel , Tellgren-Roth Christian , Heintz Julia , Pettersson Olga Vinnere , Jondelius Ulf 
Published: July 2023

AbstractBackgroundXenacoelomorpha is a marine phylum of microscopic worms that is an important model system for understanding the evolution of key bilaterian novelties, such as the nervous or excretory systems. Nevertheless, Xenacoelomorpha genomics has been restricted to the few species that either can be cultured in the lab or are centimetres long. Thus far, no genomes are available for Nemertodermatida, one of the phylum’s main clades and whose origin has been dated more than 400 million years ago.ResultsWe present the first nemertodermatid genome sequenced from a single specimen ofNemertoderma westbladi. Although genome contiguity remains challenging (N50: 48 kbps), it is very complete (BUSCO: 81.4%, Metazoa; 91.8%, Eukaryota) and the quality of the annotation allows fine-detail analyses of genome evolution. Acoelomorph genomes seem to be conserved in terms of the percentage of repeats, number of genes, number of exons per gene and intron size. In addition, a high fraction of genes present in both protostomes and deuterostomes are absent in Acoelomorpha. Interestingly, we show that all genes related to the excretory system are present in Xenacoelomorpha butOsr, a key element in the development of these organs and whose acquisition might explain the origin of the specialised excretory system.ConclusionsOverall, these analyses highlight the potential of the Ultra-Low Input DNA protocol and HiFi to generate high-quality genomes from single animals, even for relatively large genomes, making it a feasible option for sequencing challenging taxa, which will be an exciting resource for comparative genomics analyses.
Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
Authors: Ravi Sundar Jose Geetha Aarathy , Fischer Katrin , Smesnik Georg , Vogt Alex , Platanitis Ekaterini , Müller Mathias , Farlik Matthias , Decker Thomas 
Published: July 2023

ABSTRACTType I interferons (IFN-I, including IFNβ) and IFNγ produce overlapping, yet clearly distinct immunological activities. Recent data show that distinctness of global transcriptional responses to the two IFN types is not apparent when comparing their immediate effects. By analyzing nascent transcripts induced by IFN-I or IFNγ over a period of 48hrs we now show that the distinctiveness of the transcriptomes emerges over time and is based on a different employment of the ISGF3 complex as well as the second-tier transcription factor IRF1. The distinct transcriptional properties of ISGF3 and IRF1 correspond with a largely diverse nuclear protein interactome. Mechanistically, we describe specific input of ISGF3 and IRF1 into enhancer activation and the regulation of chromatin accessibility at interferon-induced genes (ISG). We further report differences between the IFN types in altering RNA polymerase II pausing at ISG 5’ ends. Our data provide insight how transcriptional regulators create immunological identities of IFN-I and IFNγ.