bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-pregnancy weight loss associations with prenatal and postpartum mental health conditions: A retrospective cohort study
Authors: Ferber Megan , Chrusciel Timothy , Cantwell Sophia , Salas Joanne , Christopher Kara M. 
Published: September 2023

Abstract
Background: Obesity is a risk factor for adverse outcomes during and following pregnancy. Most women are advised to lose weight prior to becoming pregnant, to help alleviate complications including prenatal and postpartum depression and anxiety. Yet, no studies have examined how the process of losing weight prior to pregnancy interacts with the development of prenatal and postpartum mental health disorders.The objective of the study was to determine if women with pre-pregnancy weight loss (≥10%) vs. those who do not, in the two years prior to pregnancy, have a lower risk for new onset prenatal and postpartum mental health conditions
Methods: This retrospective cohort study used data from the Virtual Data Warehouse of a large Midwestern, U.S. based hospital system. The final sample consisted of 6,085 female patients of reproductive age that had given birth between 10/1/2011-6/30/2020 and had two recorded weights in the year prior to conception. Univariate analysis between weight loss and outcome variables (pre-natal and post-partum depression and anxiety) and multivariate analysis using logistic regression was conducted for variable significant on univariate analysis.
Results: On univariate analysis, women with pre-pregnancy weight loss had increased odds of post-partum depression (OR=1.47, 95%CI=1.03-2.10), though decreased odds of prenatal anxiety (OR=0.59, 95% CI 0.33-0.90). After controlling for confounders in the multivariate analysis, there was not a significant difference in the odds of post-partum depression; however, women who lost weight had approximately half the odds of having prenatal anxiety than those who did not lose weight (OR=0.54, 95%CI=0.33-0.90).
Discussion: The experience of achieving weight loss prior to pregnancy may foster a sense of agency within pregnant women, helping them to reduce their experience of pre-natal anxiety. Providers could engage in patient conversations around weight loss and mental health management in a strengths-based framework to continue to foster this sense of agency.
Conclusion: Anxiety and depression were uniquely related to pre-pregnancy weight loss. Pre-pregnancy weight loss was associated with lower odds of prenatal anxiety and higher odds of postpartum depression. These results highlight the need for real world examination of pre-conception treatment recommendations and their association with non-physical health-based outcomes.
Improving bridge effect to overcome interspecific hybrid sterility by pyramiding hybrid sterile loci from Oryza glaberrima
Authors: Li Jing , Zhou Jiawu , Xu Peng , Ying Yang , Deng Xianneng , Deng Wei , Zhang Yu , Lv Yonggang , Pu Qiuhong , Tao Dayun 
Published: September 2023

Abstract
In order to evaluate the hybrid sterile effect and the bridging effect caused by the hybrid sterile locus, total nine NILs carrying one, two and three alleles of O. glaberrima were developed and used as test lines to cross with O. sativa and O. glaberrima accessions. The results showed that the degree of pollen sterility of F1 hybrids between the NILs and Dianjingyou 1 has deepened with the increase of the number of alleles from O. glaberrima at the hybrid sterile loci. Under the action of three hybrid sterile loci, F1 hybrids between the two cultivated rice species are almost completely sterile. On the other hand, the NILs carrying a single allele of O. glaberrima had limited effect on improving pollen fertility of interspecific hybrid. The pyramided lines containing multiple sterile alleles of O. glaberrima showed increased pollen fertility when crossing with O. glaberrima accessions. Further the backcrossing can be used to improve pollen and spikelet fertility of interspecific hybrids after the first cross. The report has potential for understanding the nature of interspecific hybrid sterility, and overcoming the interspecific hybrid F1 pollen grain sterility between O. sativa and O. glaberrima.
Endoscopic main duct stenting in refractory postoperative pancreatic fistula after distal pancreatectomy – a friend or a foe?
Authors: Linder Stefan , Holmberg Marcus , Agopian-Dahlenmark Louiza , Zhao Helena , Åkerström Johan Hardvig , Sparrelid Ernesto , Ghorbani Poya 
Published: September 2023

Abstract
Background
Clinically relevant (CR) postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) are common. Endoscopic treatment (ET) has only scarcely been explored. The aim of this study was to evaluate risk factors for CR POPF after DP and the efficacy of ET in adjunct to standard therapy.
Methods
Consecutive patients without previous pancreatic surgery who underwent DP between 2011 and 2020 were evaluated, analyzing risk factors for CR POPF. The choice and performance of ET, main pancreatic duct (MPD) stenting, was not standardized. Healing time and complications after ET were registered.
Results
406 patients underwent DP, CR POPF occurred in 29.6%. ET was performed in 17 patients 27 days (median) after index surgery. Risk for CR POPF was increased in ASA-PS 1–2 patients, MPD ≤ 3mm, procedure time ≥ 3h, and CRP ≥ 180 on postoperative day 3. POPF resolved with standard treatment after 32 days and 59 days in the ET group (p < 0.001). There was one mortality in the ET-group (not procedure related). Mild post-ERCP pancreatitis occurred in three patients.
Conclusions
CR POPF is common after DP. Long operating time, a narrow MPD, low ASA score, and high postoperative CRP were risk factors for CR POPF. ET was not beneficial but proper evaluation was not possible due to few patients and non-standardized treatment. Complications after ET appeared mild.
The Brazilian national prospective active surveillance (AS) cohort of patients with low-risk prostate cancer in the public health system: vigiaSUS study protocol
Authors: Basso Jeziel , de Lima Juliana Beust , Bessel Marina , Leitão Santiago Alonso Tobar , Baptista Thais Machado , Roithmann Sergio , Carvalhal Eduardo Franco , Schmitt Caio , Pedrollo Ivan , Schuch Alice , Hartmann Antonio Atalibio , Estivallet Carmen , Ribeiro Guilherme Behrend Silva , Zordan Ricardo Andre , Velho Pedro Henrique Isaacsson 
Published: September 2023

Abstract
Background
Prostate cancer exhibits a very diverse behaviour, with some patients dying from the disease and others never needing treatment. Active surveillance (AS) consists of periodic PSA assessment (prostate-specific antigen), DRE (digital rectal examination) and periodic prostate biopsies. According to the main guidelines, AS is the preferred strategy for low-risk patients, to avoid or delay definitive treatment. However, concerns remain regarding its applicability in certain patient subgroups, such as African American men, who were underrepresented in the main cohorts. Brazil has a very racially diverse population, with 56.1% self-reporting as brown or black. The aim of this study is to evaluate and validate the AS strategy in low-risk prostate cancer patients following an AS protocol in the Brazilian public health system.
Methods
This is a multicentre AS prospective cohort study that will include 200 patients from all regions of Brazil in the public health system. Patients with prostate adenocarcinoma and low-risk criteria, defined as clinical staging T1–T2a, Gleason score ≤ 6, and PSA < 10 ng/ml, will be enrolled. Archival prostate cancer tissue will be centrally reviewed. Patients enrolled in the study will follow the AS strategy, which involves PSA and physical examination every 6 months as well as multiparametric MRI (mpMRI) and prostate biopsy annually. The primary objective is to evaluate the reclassification rate, and secondary objectives include determining the treatment-free survival rate, metastasis-free survival, and specific and overall survival. Exploratory objectives include the evaluation of quality of life and anxiety, the impact of PTEN loss and the economic impact of AS on the Brazilian public health system.
Discussion
This is the first Brazilian prospective study of patients with low-risk prostate cancer under AS. To our knowledge, this is the largest AS study cohort with a majority of nonwhite patients. We believe that this study is an opportunity to better understand the outcomes of AS in populations underrepresented in studies. Based on these data, an AS national clinical guideline will be developed, which may have a beneficial impact on the quality of life of patients and on public health.
Trial registration:
Clinicaltrials registration is 56352622.8.1001.5330
Study on clinical application of 3D printing model in the extraction of donor tooth for autotransplantation
Authors: Hou Rui , Hui Xiaoyong , Xu Guangjie , Li Yongqing , Yang Xia , Xu Jie , Liu Yanli , Zhu Minghui , Zhu Qinglin , Sun Yu 
Published: September 2023

Abstract
Objective To clarify whether the 3D printing model has auxiliary functions in toto extraction of donor tooth (DT) for autotransplantation of teeth (ATT).Methods A questionnaire survey was designed to investigate the auxiliary function of 3D model in extraction. Then, a clinical study was designed on intra-group comparison between the predicted and actual donor teeth situation in different cases. Finally, the consistent rate for the predicted results and the actual results were compared with the two groupsResults The overall difficulty of general practitioners was significantly higher than surgeons (p = 0,031). General practitioners believed that the model is more beneficial than the surgeon in the complete extraction of donor teeth, and the difference was statistically in the evaluation of the root number and root curvature of donor teeth. A remarkable difference was observed between the predicted results and the actual results of tooth positions and root numbers in group without model (p < 0,05). The consistency rate of the model group (94.62%) was significantly higher than that of non 3D model group (86.15%) (p = 0.034).Conclusion The 3D printing model of DT is helpful for dentists to predict the accuracy of toto extraction in donor teeth.
Synchronization of Two Symmetric Bones of the Human Body for Control of Bone Cancer
Authors: Abadi Ali Soltani Sharif , Rafeeyan Mansour , Abootalebi Vahid 
Published: September 2023

Abstract
The human body has symmetric bones. This paper uses control engineering concepts to design a suitable controller to synchronize two symmetric bones of the human body to control and treat bone cancer. A Nonsingular Terminal Sliding Mode Control (NTSMC) method will be employed to design the proposed control inputs. The control inputs can be the chemical drugs that can be used to treat bone cancer. The dynamical equations of bone cancer will be used to apply the designed control method and test it. For testing the designed controller, Simulink/MATLAB software will be used. The proposed controller is chattering-free, robust against uncertainties and external disturbances, and finite-time stable in the control engineering view. Bone cancer will be treated for almost one year using the proposed control method.
Artificial Intelligence Carbon Neutrality Strategy in Sports Event Management based on STIRPAT-GRU and Transfer Learning
Authors: Zhang Ying 
Published: September 2023

Abstract
With the increasing concern about carbon emissions and climate change, carbon neutrality has become a crucial issue in various domains, including sports event management. Artificial intelligence has shown great potential in addressing environmental challenges and improving sustainability. To develop AI-powered carbon neutrality strategies for sports event managementthe ,this paper proposed a method based on STIRPAT-GRU and transfer learning. The primary objective of this research is to analyze the impact of population, wealth, and technology on carbon emissions in sports event management and to predict future trends and patterns of carbon emissions. Firstly, the STIRPAT model is used to identify the key drivers of carbon emissions in sports events. Then, the GRU neural network is then used to develop a predictive model to forecast future trends and patterns of carbon emissions. Finally, transfer learning is used to improve the accuracy and robustness of the model by leveraging knowledge and experience gained from other domains.The experimental results show that the proposed approach outperforms other methods, demonstrating its effectiveness in predicting carbon emissions in sports events and developing a carbon neutrality strategy. The significance of this research lies in its potential to provide sports event managers with a data-driven approach to manage carbon emissions, leading to a more sustainable and environmentally friendly sports industry.
A Multicenter Study: Demographic, Immunological and Clinical Characteristics in Systemic Sclerosis Patients in Latvia.
Authors: Ivanova Kristine , Ribakova Olga , Mihailova Anna , Mozeitovica Evelina , Kadisa Anda , Zepa Julija , Kenina Viktorija , Kurjane Natalja , Bulina Inita 
Published: September 2023

Abstract

Background
Systemic sclerosis (SSc) is considered by many to be one of the most severe autoimmune rheumatic diseases with lower prevalence observed in Northern Europe. No previous studies on the prevalence of SSc in Latvia have been conducted and the aim was to study the demographic and clinical data of patients with SSc in northeastern Europe country.
Methods
This study was conducted in two main Latvian hospitals for adults and includes patients with SSc who were consulted between 2016 and 2021.
Results
During the study period, 159 patients with SSc were consulted. The point prevalence on 1 January 2021 was 84.0 per million. Antinuclear antibodies were present in 82.58% of patients, equally in females (82.81%) and in males (81.41%). Centromere pattern was more frequently observed in females than in males (40.19% vs 19.04%), while speckled pattern was the most frequently observed pattern in both genders (50.98% vs 57.14%). At disease onset females tended to be younger (46.51 ± 13.52) than males (50.5 ± 16.64). More than half of patients received treatment with glucocorticoids at any point of the disease (68.31%).
Conclusions
Systemic sclerosis is less common in Latvia than in other countries and regions. Due to its location, the data from Latvia are consistent with a north-south gradient in Europe. ANA presence did not differ between genders, but in females centromere pattern was much more likely to be present. More than half of patients received treatment with GCs at any point of the disease.
Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension
Authors: Gkousioudi Anastasia , Razzoli Margherita , Moreira Jesse D. , Wainford Richard D. , Zhang Yanhang 
Published: September 2023

Abstract
The prevalence of hypertension increases with aging and is associated with increased arterial stiffness. Resistant hypertension is presented when drug treatments fail to regulate a sustained increased blood pressure. Given that the mechanisms between the sympathetic nervous system and the kidney play an important role in blood regulation, renal denervation (RDN) has emerged as a therapeutic potential in resistant hypertension. In this study, we investigated the effects of RDN on the biomechanical response and microstructure of elastic arteries. Common carotid arteries (CCA) were excised from 3-, 8- and 8-month-old denervated rats, and subjected to biaxial extension-inflation test. Our results showed that hypertension developed in the 8-month-old rats. The sustained elevated blood pressure resulted in arterial remodeling which was manifested as a significant stress increase in both axial and circumferential directions after 8 months. RDN had a favorable impact on CCAs with a restoration of stresses in values similar to control arteries at 3 months. After biomechanical testing, arteries were imaged under a multi-photon microscope to identify microstructural changes in extracellular matrix (ECM). Quantification of multi-photon images showed no significant alterations of the main ECM components, elastic and collagen fibers, indicating that arteries remained intact after RDN. Regardless of the experimental group, our microstructural analysis of the multi-photon images revealed that reorientation of the collagen fibers might be the main microstructural mechanism taking place during pressurization with their straightening happening during axial stretching.
Changes in perceptions of antibiotic stewardship among neonatal intensive care unit providers over the course of a learning collaborative: A prospective, multi-site, mixed methods evaluation
Authors: Qureshi Nabeel , Kroger Jack , Zangwill Kenneth , Joshi Neha , Payton Kurlen , Mendel Peter 
Published: September 2023

Abstract
Objective: To assess clinician perceptions towards the value and implementation of antibiotic stewardship (AS) in neonatal intensive care units (NICU).
Study Design: We performed a mixed methods study of AS perceptions (prescribing appropriateness, importance, activity, capacity) using surveys and interviews in 30 California NICUs before and after a multicenter collaborative (Optimizing Antibiotic Use in California NICUs [OASCN]).
Results: Pre-OASCN, 24% of respondents felt there was “a lot of” or “some” inappropriate prescribing, often driven by fear of a bad outcome or reluctance to change existing practice. Clinicians reported statistically significant increases in AS importance (71 v 79%), perceived AS activity (67 v 87%), and more openness to change after OASCN (59 v 70%). We identified other concerns that lessen AS effort.
Conclusion: OASCN increased perceived AS activity and openness to change in AS practices among NICU prescribers. Greater attention to subjective concerns should augment AS improvement.
The simplest approach for the hand calculation of pseudo-first order rate constants for abiotic reduction of organic compounds
Authors: Keshavarz Mohammad Hossein , Shirazi Zeinab , Jafari Mohammad , Rajabi Arezoo 
Published: September 2023

Abstract
A new method is introduced to predict pseudo-first order rate constants (kobs) for abiotic reduction of organic compounds with diverse reducible functional groups, including aliphatic nitro-compounds (ANCs), nitroaromatic compounds (NACs), aromatic N-oxides (ANOs), polyhalogenated alkanes (PHAs), isoxazoles (ISXs), sulfoxides and sulfones (SOs), and others. The largest experimental data of -logkobs for 59 organic compounds are used to derive and test the new model. In comparison to available quantitative structure-activity relationship (QSAR) methods where need computer codes, complex descriptors, and expert users, the novel method requires experimental conditions and structural parameters of the desired organic compounds. The calculated outputs of the new method are compared with the results of one of the best QSARs methods, which requires energy of the lowest-unoccupied molecular orbital. The values of statistical factors comprising average absolute deviation (AAD), mean error (ME), absolute maximum deviation (ADmax), average absolute relative deviation (AARD%), and R-squared (R2) of the estimated outputs for 54/5 training/test data sets of the new method are 0.663/1.311, -0.056/-0.165, 1.788/1.215, 19.10/74.07, and 0.796/0.958, respectively. Meanwhile, AAD, ME, ADmax, AAD%, and R2 for comparative QSAR method are 0.731/2.301, 0.601/1.126, 3.795/3.732, 641/821, and 0.003/0.447, respectively. Thus, the new model provides the simplest approach for the hand calculation of -logkobs with great goodness-of-fit, reliability, precision, and accuracy.
Wellbore Stability in a Depleted Reservoir by Finite Element Analysis of Coupled thermo-poro-elastic Units in an Oilfield, SW Iran
Authors: Pirhadi Alireza , Kianoush Pooria , Ebrahimabadi Arash , Shirinabadi Reza 
Published: September 2023

Abstract

Maintaining wellbore stability in depleted reservoirs is a critical problem. With production from hydrocarbon reservoirs, the pore pressure of the reservoir is reduced over time, and the reservoir is depleted since field development is one of the main purposes for oil companies. Heavy mud weight in depleted reservoir caused fracture due to reduced fracture gradient, and low mud weight caused blow out in high-pressure zone or well collapse due to shale beds that required high mud weight to prevent collapse. Considering geomechanics and coupled equilibrium equation, continuity equation, Hook’s law, compatibility equation, Darcy’s law, and thermal relation, the Thermo-poro-elastic equation was derived in this research. A finite element method has been developed to implement the fully coupled thermo-poro-elastic non-linear models. The finite element model was validated by comparing it to the available analytical solutions for the thermo-poro-elastic wellbore problems in shale. The non-linear thermal-poro-elasticity finite element model was used to analyze wellbore stability in a depleted limestone reservoir during drilling. The numerical results showed that a decrease drilling fluid’s temperature (cooling) causes to increase in the potential for tensile failure and reduces the potential of shear failure. Due to the depletion reservoir, the potential of tensile failure increased than shear failure, so heating the drilling fluid could cause wellbore stability in the depleted reservoir. Furthermore, based on the numerical results, it may be concluded that the drilling fluid’s temperature is one of the important factors in the wellbore stability analysis in depleted reservoirs.
Phase Envelopes in Reservoir Fill Analysis
Authors: Arouri Khaled R. , Herrera Carlos G. 
Published: September 2023

Abstract
Phase envelopes are routinely employed by reservoir engineers for fluid characterization. These envelopes are controlled by the reservoir PVT conditions, but fundamentally also by the hydrocarbon fluid type and composition. As a result of increasing source-rock maturation, fluids with decreasing average molecular weights, decreasing densities and increasing gas-to-oil ratios (and hence different phase envelopes) are generated, which are thus linked to fluid history. In addition to their importance for exploration, charge models can play a key role in constraining reservoir models and in optimising field development, particularly when PVT data are properly integrated with fluid geochemistry. Two distinct patterns of fluid phase evolution from two different fields are presented, and their relations to charge analysis and reservoir models are discussed. The first example discusses the identification, based on hydrocarbon geochemistry complemented by overlapping phase envelopes, of compartmentalised filling cycles in what was initially considered a single oil-rimmed gas accumulation. The second example presents an opposite scenario where two wet gas accumulations 20-km apart laterally and 400-feet average depth difference appear to represent a single more-expansive accumulation spread over areas of variable PVT conditions and reservoir qualities. The wet gas across both accumulations is characterised by a continuous phase evolution pattern that shrinks systematically (cricondentherm shifts to lower temperature and cricondenbar to lower pressure) suggestive of phase fractionation of a charge of single maturity. The proposed gas distribution model represents a discovery of a hybrid conventional and unconventional (tight sand) system, with potential for basin-centered gas.