bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of abdominal stab wounds: A retrospective evaluation of 100 cases in a low- incidence environment
Authors: Lerchenberger Maximilian , Krendl Felix J. , Karcz Konrad , Schirren Malte , Zhang Yunjie , Hallfeldt Klaus , Ladurner Roland 
Published: April 2023

Abstract
Purpose
Abdominal stab wounds (ASW) represent a rare subclass of trauma in Europe and might therefore cause uncertainty in choosing the adequate therapeutic approach. Therefore, the aims of this retrospective study were (1) to investigate patient outcome with regard to the treatment method and (2) to develop a diagnostic and therapeutic algorithm for laparoscopic surgery.
Methods
100 cases of (thoraco-) abdominal stab wounds (T/ASW)were identified from 2003 to 2019. A review of the medical records identified injury patterns, Injury Severity Score, diagnostic approaches, therapy, morbidity and mortality, length of treatment, and patient outcomes.
Results
T/ASW occurred in 53 cases due to violent crime, in 11 cases due to accidents and in 36 cases with suicidal intent. Gender distribution was 82 male, 18 female, and the average age was 41 years. The majority (n = 65) of these patients were admitted to our center via the trauma unit. 33 patients received local wound exploration and were admitted to the hospital for observation. Two of these patients deteriorated during the observation period and were admitted to the OR. Laparoscopy was performed in 27 cases, with 6 conversions to laparotomy. 39 patients underwent primary laparotomy. Overall, complications requiring further intervention occurred in six cases. Four patients died; three patients died postoperatively, and one patient died in the trauma bay. The length of hospital stay was significantly shorter int patients undergoing laparoscopic treatment than in patients receiving laparotomy.
Conclusion
The decision for surgical exploration of ASW should be made generously. Primary laparoscopic exploration is recommended in stable patients. For critically injured patients, laparotomy remains the gold standard.
PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties
Authors: Bahraoui Sarah , Tejedor Gautier , Mausset-Bonnefont Anne-Laure , Autelitano François , Jorgensen Christian , Wei Mingxing , Djouad Farida 
Published: April 2023

Abstract
Background: Initially discovered for its ability to regenerate ear holes, the MRL mouse has been the subject of multiple research studies aimed at evaluating its ability to regenerate other body tissues and at deciphering the mechanisms underlying it. These enhanced abilities to regenerate, retained in the adult, protect the MRL mouse from degenerative diseases such as osteoarthritis (OA). Here, we hypothesized that MSC derived from the regenerative MRL mouse could be involved in their regenerative potential through the release of pro-regenerative mediators.
Method: To address this hypothesis, we compared the transcriptome of MRL and BL6 MSC and identified several candidate molecules expressed at significantly higher levels by MRL MSC than by BL6 MSC. We selected one candidate and performed functional in vitro assays to evaluate its role on MRL MSC properties including metabolic profile, migration, and chondroprotective effects. Using an experimental model for osteoarthritis (OA) induced by collagenase (CiOA), we assessed its contribution to MRL MSC protection from OA.
Results: Among the candidate molecules highly expressed by MRL MSC, we focused our attention on procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), coding for the lysyl hydrolase LH2 in charge of post-translational modifications of collagen for its stability and stiffness. PLOD2 is induced by hypoxia-inducible factor 1-alpha (HIF-1a) involved in the regeneration process of adult MRL mice. Plod2 silencing induced a decrease in the glycolytic function of MRL MSC, resulting in the alteration of their migratory and chondroprotective abilities in vitro. In vivo, we showed that plod2 silencing in MRL MSC significantly impaired their capacity to protect mouse from developing OA.
Conclusion: Our results demonstrate that the chondroprotective and therapeutic properties of MRL MSC in the CiOA experimental model are in part mediated by PLOD2.
Ecofloristic characterization of medicinal flora of Kisantu and Mbanza-Ngungu territories, in Kongo-Central Province, DR Congo
Authors: Kembelo Pathy Kibungu , Bakwaye Flavien Nzuki , Katula Honoré Belesi , Tsimba Francois , Vanhove Wouter , Damme Patrick Van 
Published: April 2023

Abstract
We accessed the composition and dynamics of the vegetation in the Kisantu and Mbanza-Ngungu territories, as well as the distribution and availability of medicinal plants in their harvesting areas, using stigmatist and eco-floristic approaches. The flora was composed of 709 botanical species (113 families and 446 genera). The most abundant taxa were from Fabaceae family (14.8%), and used for medicinal purposes. Herbs (47.4%), pantropical (28.9%), phanerophytes (50.8%), species with sarcochorous diaspores (39.2%), with mesophilic leaves (49.08%) and species belonged to the Musango-Terminalietea (27.9%) group were the most dominant. The most abundant taxa were from dryland forests (45.4 ± 11.9.9) and anthropized formations (43.08 ± 11.4.4). Most species (62.04%) had a very restricted ecological niche, whereas 2.24%, had a very wide distribution. The highest similarity indices were observed, in descending order, between (1) dryland and swamp forests (KS: 70.7; JC: 26.1), (2) savannahs and dryland forests (KS: 55. 01; JC: 21.6), (3) anthropized formations and dryland forests (KS: 46.7; JC: 18.9), and (4) anthropized formations and savannahs (KS: 41.9; JC: 17.3). The Highest dissimilarity index was observed in anthropized formations (35%) and swamp forests (33%). Plant formations have a natural succession defined by vegetation dynamics from the pioneer stage to the climax stage. Field observations indicated that most habitats are degraded and that the availability of medicinal plants is decreasing. Adequate conservation measures, including in-situ and ex-situ methods are essential to promote and ensure the sustainable supply of medicinal plants to the communities that depend on these resources.
Using visual scores and categorical data for genomic prediction of complex traits in breeding programs
Authors: Azevedo Camila Ferreira , Ferrão Luis Felipe Ventorim , Benevenuto Juliana , de Resende Marcos Deon Vilela , Nascimento Moyses , Nascimento Ana Carolina Campana , Munoz Patricio R 
Published: April 2023

Abstract
Most genomic prediction methods are based on assumptions of normality due to their simplicity and ease of implementation. However, in plant and animal breeding, traits are often collected as categorical data, thus violating the normality assumption, which could affect the prediction of breeding values and the estimation of genetic parameters. In this study, we examined the main challenges of categorical phenotypes in genomic prediction and genetic parameter estimation using mixed models, Bayesian and machine learning methods. We evaluated these approaches using simulated and real breeding data sets. Our contribution in this study is a five-fold demonstration: (i) collecting data using an intermediate number of categories (1 to 3 and 1 to 5) is the best strategy, even considering errors associated with visual scores; (ii) Linear Mixed Models and Bayesian Linear Regression are robust to the normality violation, but marginal gains can be achieved when using Bayesian Ordinal Regression Models (BORM) and Random Forest Classification; (iii) genetic parameters are better estimated using BORM; (iv) our conclusions using simulated data are also applicable to real data in autotetraploid blueberry; and (v) a comparison of continuous and categorical phenotypes found that investing in the evaluation of 600–1000 categorical data points with low error, when it is not feasible to collect continuous phenotypes, is a strategy for improving predictive abilities. Our findings suggest the best approaches for effectively using categorical traits to explore genetic information in breeding programs and highlight the importance of investing in the training of evaluator teams and in high-quality phenotyping.
The interrelationship of childbirth-related pelvic floor injury in primiparas after vaginal delivery
Authors: Zhang Cheng , Zhao Yujiao , You Cong , Li Xiaotian , Wu Yanhong , Zhang Xiaodong , Shen Wen 
Published: April 2023

Abstract
Objective
This study aimed to explore the underlying relationship between the pubic bone injury and levator ani muscle injury.
Methods
150 primiparas after vaginal delivery were prospectively enrolled and divided into the pubic bone injury group and the non-pubic bone injury group according to imaging appearance on postpartum magnetic resonance imaging. The levator ani muscle morphology and function were evaluated, including injury score, H line, M line, levator plate angle, iliococcygeal angle, and levator hiatus area. The levator ani muscle morphology and function were compared between the two groups using univariate analysis. The association between the severity of the pubic bone injury and the levator ani muscle injury was calculated using the Spearman or Kendall's tau-b correlation coefficient.
Results
Compared to the non-pubic bone injury group, the pubic bone injury group more frequently complained of pelvic pain and stress incontinence (28% vs. 9.3%, P = 0.003; 29.3% vs. 13.3%, P = 0.017, respectively). The levator ani muscle morphological injury score, the H line at straining, the M line, and the levator hiatus area at rest and straining were different between the two groups (all P < 0.05). There was a positive correlation between the severity of the pubic bone injury and levator ani muscle injury score (r = 0.332), M line (r = 0.139, 0.150), and levator hiatus area (r = 0.181, 0.164) at rest and straining, respectively (all P < 0.05).
Conclusions
The pubic bone injury was a reliable reminder of morphological injury and decreased function in levator ani muscle.
A Low Layered Deep Network Model for the Classification of Skin Dermoscopy Images
Authors: AMBIKA M , RAO P. TRINATHA 
Published: April 2023

Abstract
One of the deadliest forms of skin cancer is Melanoma. This is increasing gradually, especially in males and can be treated if diagnosed at early stages. Manual inspection involves critical inspection by dermatologists and the decision requires a lot of expertise and consumes lot of time, hence there is a need to develop automated lesion detection and classification system with image processing and deep learning methods. There are several image processing methods were proposed in the research however there is a scope to automate the entire with deep learning methods. This paper proposes low layered, high performance deep network architecture for the classification of skin lesion images and evaluates the performance of the network with standard datasets. The work also focuses on comparing the performance evaluation metrics against state of art networks and highlights the need for new customized networks.
Acculturating to Multiculturalism: A New Dimension of Dietary Acculturation among Asian American, Native Hawaiian, and Pacific Islander Women in the San Francisco Bay Area, USA
Authors: Tan Judy , Guan Alice , Albers Autumn E. , Canchola Alison J. , Allen Laura , Shariff-Marco Salma , Gomez Scarlett Lin 
Published: April 2023

Abstract
Dietary acculturation is the process by which diet and dietary practises prevalent in a new environment are adopted and/or those from the environment of origin are retained or changed. Knowledge gaps exist on chracterising dietary acculturation among Asian American, Native Hawaiian, and Pacific Islander communities (AANHPI), despite rapid population growth the USA. This study characterise dietary patterns in a sample representative of AANHPI on key demographic characteristics. Data were from a 2013–2014 population-based case-control study in the San Francisco Bay Area, U.S. Survey items were adapted from dietary acculturation scales developed for Chinese, Filipinx, Vietnamese, Japanese, Korean, and Asian Indian and Pakistani populations. Validated measures assessed social networks, social standing, discrimination and immigration experiences. A principle components factor analysis characterise dietary patterns of acculturation. Three dietary patterns were identified: “Asian,” “Western,” and a distinct “Multicultural” factor. Respondents reporting a high-Asian diet tended to also report smaller social networks, higher levels of stress, and, among those born outside of the U.S., an educational standing that was better before immigration. Respondents who ate a high-Western diet tended to also report the highest level of discrimination. Those reporting a high-Multicultural diet tended to report higher neighbourhood collective efficacy. The finding of a distinct “Multicultural” factor beyond the typical “Asian” and “Western” factors may reflect the multidirectional nature of dietary acculturation, in which origin and destination cultures interact in complex ways and where foods from multiple ethnicities intermix.
Dual Double Point Cloud Transformer
Authors: Zhong Qi , Han Xian-Feng , Fang Cheng-Yu , Yang Lu 
Published: April 2023

Abstract
Long-range context relationship plays an important role in understanding point clouds. Inspired by the permutation invariance of the recent Transformer models, in this paper, we propose an end-to-end Dual Double Transformer (DDTFormer) architecture for 3D point cloud processing. Specifically, two core components, termed point-wise double transformer and channel-wise double transformer blocks, are well designed for explicitly modeling interdependencies among points and channels. And both blocks consist of two key operations: aggregation attention mapping the point-wise/channel-wise feature maps into a global space, and propagation attention diffusing the aggregated features back to the input points or channels. We illustrate the effectiveness and competitiveness via extensive quantitative and qualitative experiments on 3D shape classification and segmentation benchmark datasets.
Navitoclax mediates Interleukin-3 induced human umbilical vein endothelial cells survival and angiogenesis
Authors: Hisam Nur Syahidah Nor , Ugusman Azizah , Rajab Nor Fadilah , Gregoli Karina Di , Ahmad Mohd Faizal , Anuar Nur Najmi Mohamad 
Published: April 2023

Abstract
Navitoclax is an effective pro-apoptotic agent against cancer cells. Uncontrolled cell survival is a hallmark of pathological angiogenesis in cancer and could promote plaque instability that contributes to atherosclerosis progression owing to intraplaque neovascularization. Cancer cell inhibition by navitoclax can restrain metastasis; therefore, it is possible to reduce endothelial cells survival and is expected to confer a novel therapeutic strategy for advanced atherosclerosis in regards to plaque instability. However, regulation of endothelial cell activity by navitoclax is yet to be examined. This study will analyze navitoclax efficacy in modulating human umbilical vein endothelial cells (HUVEC) viability, proliferation, migration and angiogenesis. Navitoclax concentrations ranging from 0.2 to 3.0µM at four-time points; 18-, 24-, 48- and 72-hours were used for MTT assay. The IC50 value for 18-hours post-treatment was undefined due to low efficacy at a limited time. While for 24-, 48- and 72-hours, the IC50 values were 0.91µM, 0.72µM, and 0.12µM, respectively. Navitoclax potency to inhibit HUVEC viability increased as the treatment time elevated. 0.9µM navitoclax for 24 hours treatment was selected for subsequent experiments. Next, 25 ng/ml IL-3 was used to induce the in-vitro angiogenesis model within 6 hours. Expectedly, navitoclax reduced the tube formation and migration of HUVEC induced by IL-3 in consistent with CXCL-8 released and MMP-3 expression in the cell. However, HUVEC proliferative activity was not affected by navitoclax treatment, as well as the BCL-2 gene expression. Therefore, an anti-angiogenic effect of navitoclax on HUVEC by preventing the cell motility through CXCL-8 and MMP-3 mechanism is determined.
Exact travelling wave solutions of time-fractional Clannish Random Walker's Parabolic equation and sensitive analysis
Authors: Asjad Muhammad Imran , Ashaq Hira , Faridi Waqas Ali , Majid Sheikh Zain 
Published: April 2023

Abstract
In this article, the new extended direct algebraic method is used to build the exact travellingwave solutions for the non-linear time-fractional Clannish Random Walker’s Parabolic equation.This study establishes the framework in which periodic, singular, dark, bright and kink-typewave solitons are obtained with exact solutions offered by the mixed hyperbolic and trigonom-etry solutions, mixed periodic and periodic solutions, plane solutions, shock solutions, mixedtrigonometric solutions, mixed singular solutions, mixed shock single solutions, complex solitarysingular solutions, shock solutions and shock wave solutions. The exact soliton solutions of thetime-fractional clannish random walker’s parabolic equation model is graphically presented atdifferent values of involved parameters by Wolfram Mathematica software. The propagating behaviours display in 3-D, contour and 2-D surfaces of the obtained results to visualise the im-pact of the involved parameters. The sensitivity analysis is demonstrated for the wave profilesof the designed dynamical framed structure, where the soliton wave number parameter regulatesthe water wave singularity. This analysis illustrates that the utilized method is efficient andreliable and can be useful to find appropriate solutions in closed-form solitary soliton to a wide range of non-linear evolution equations. These techniques can also be utilised to find new exact travelling wave solutions for any class of integer or fractional differential equations thatarise in mathematical physics.
A Case of Nocardiosis in a Patient with Ulcerative Colitis on Chronic Corticosteroids and Treated with Upadacitinib
Authors: Moy Benjamin M. , Shenoy Abhishek , Aldrich Leslie B. 
Published: April 2023

Abstract
The immunosuppressive effects of treatment for ulcerative colitis, including chronic corticosteroids, anti-TNF agents, and JAK inhibitors, can impact the spread of latent or obscure infections. Clinicians should have low thresholds for aggressive diagnostic and therapeutic intervention if patients show signs of clinical deterioration while on upadacitinib. Our unique case highlights an immunosuppressed patient with ulcerative colitis who developed Nocardiosis after initiation of upadacitinib while hospitalized for concurrent UC flare and C. difficile infection.
The Role of Political Stability in the Context of ESG Models at World Level
Authors: Costantiello Alberto , Leogrande Angelo 
Published: April 2023

Abstract
In this article, we estimate the role of Political Stability and Absence of Violence and Terrorism-PS in the context of Environmental, Social and Governance-ESG data at world level. We analyse data from 193 countries in the period 2011-2020. We apply Panel Data with Fixed Effects, Panel Data with Random Effects and Pooled Ordinary Least Square-OLS. We found that PS is positively associated, among others, to Population Density and Government Effectiveness, and negatively associated, among others, to Research and Development Expenditure and Maximum 5-day Rainfall. Furthermore, we apply the k-Means algorithm optimized with the application of the Elbow Method and we find the presence of four clusters. Finally, we propose a confrontation among eight different machine-learning algorithms for the prediction of PS and we find that the Polynomial Regression shows the higher performance. The Polynomial Regression predicts an increase in the level of PS of 0.25% on average for the analysed countries.
JEL Codes: D7, D70, D72, D73, D78.
A Pan-cancer Analysis of Ferroptosis-related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values
Authors: Yang Hua 
Published: April 2023

Abstract

The recent researches identify ferroptosis is an entirely new form of programmed cell death. Arachidonic acid 15-lipoxygenase-1 (ALOX15) is a key gene that mediates this process. However, the role of ALOX15 in human tumors is not clear. We conducted a pan-cancer analysis to explore the role and significance of ALOX15 in pan-cancer using multiple databases, we found the transcription and protein expression of ALOX15 were significantly reduced in HNSC, LUAD, LUSC, SKCM, KICH and THCA, were significantly up-regulated in ESCA, LIHC, PRAD and UCEC, Expression of ALOX15 had prognostic value for certain cancers such as LUAD, LUSC, LIHC, KIRC, HNSC, THCA and LGG. ALOX15 expression was also markedly correlated with the clinical characteristics, immune cell infiltration, ICKs, genomic instability and antitumor drug sensitivity of different tumors. Gene mutation of ALOX15 and prognostic value of mutation was found in pan-cancers. Moreover, GO/KEGG analysis and single-cell transcriptome sequencing showed that ALOX15 was significantly associated with cancer-related pathways. The results suggested ALOX15 might serve as a prognostic and immunotherapeutic marker for pan-cancer, might provide new direction and evidence for cancer therapy.
Ricci soliton on a class of Riemannian manifolds under D-isometric deformation.
Authors: AdelDelloum  , Beldjilali Gherici 
Published: April 2023

Abstract
In this article, we investigate the behavior of Ricci solitons under D-isometric deformations on a class of Riemannian manifolds. A D-isometry is a diffeomorphism that preserves the distance function induced by a Riemannian metric up to a constant factor. We consider a family of Riemannian metrics g on a manifold M that are related by D-isometric deformations, and we study the Ricci soliton equation on each metric g. We show that under certain conditions on the deformation function, the solutions to the Ricci-Soliton equation on each metric g are invariant. In particular, we obtain a family of Ricci-Solitons that are related by a scaling factor under D-isometric deformations. We also provide explicit examples of D-isometric deformations and compute the corresponding Ricci-Solitons.
2000 Mathematics Subject Classification. 53C15, 53C25, 53D10.