bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adoption of mHealth Technologies by Community Health Workers to Improve the Use of Maternal Health Services in Sub-Saharan Africa: Protocol for a Mixed Method Systematic Review
Authors: Kachimanga Chiyembekezo , Divala Titus H , Ket Johannes C F , Kulinkina Alexandra V , Zaniku Haules R , Murkherjee Joia , Palazuelos Daniel , Abejirinde Ibukun-Oluwa Omolade , Akker Thomas van den 
Published: March 2023

Background
Studies have shown that mobile health technologies (mHealth) enhance the use of maternal health services. However, there is limited evidence of the impact of mHealth use by community health workers (CHWs) on the use of maternal health services in sub-Saharan Africa.

Objective
This mixed method systematic review will explore the impact of mHealth use by CHWs on the use of the maternal health continuum of care (antenatal care, intrapartum care, and postnatal care [PNC]), as well as barriers and facilitators of mHealth use by CHWs when supporting maternal health services.

Methods
We will include studies that report the impact of mHealth by CHWs on the use of antenatal care, facility-based births, and PNC visits in sub-Saharan Africa. We will search 6 databases (MEDLINE, CINAHL, Web of Science, Embase, Scopus, and Africa Index Medicus), with additional articles identified from Google Scholar and manual screening of references of the included studies. The included studies will not be limited by language or year of publication. After study selection, 2 independent reviewers will perform title and abstract screening, followed by full-text screening to identify the final papers to be included. Data extraction and risk-of-bias assessment will be performed using Covidence software by 2 independent reviewers. We will use a Mixed Methods Appraisal Tool to perform risk-of-bias assessments on all included studies. Finally, we will perform a narrative synthesis of the outcomes, integrating information about the effect of mHealth on maternal health use and barriers and facilitators of mHealth use. This protocol follows the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) guidelines.

Results
In September 2022, we conducted an initial search in the eligible databases. After removing duplicates, we identified 1111 studies that were eligible for the title and abstract screening. We will finalize the full-text assessment for eligibility, data extraction, assessment of methodological quality, and narrative synthesis by June 2023.

Conclusions
This systematic review will present new and up-to-date evidence on the use of mHealth by CHWs along the pregnancy, childbirth, and PNC continuum of care. We anticipate the results will inform program implementation and policy by highlighting the potential impacts of mHealth and presenting contextual factors that should be addressed to ensure the success of the programs.

Trial Registration
PROSPERO CRD42022346364; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=346364

International Registered Report Identifier (IRRID)
DERR1-10.2196/44066
Сімейна поведінкова терапія в лікуванні ожиріння в дітей шкільного віку
Authors: Sorokman T.V. , Sokolnyk S.V. , Popeluk N.O. 
Published: March 2023

Актуальність. Ожиріння вражає 27–34 % дітей і вважається головною проблемою громадського здоров’я. Оскільки все більше дітей страждають від надмірної маси тіла, медичним працівникам необхідно шукати ефективні методи профілактики та лікування ожиріння. Мета: оцінити ефективність сімейної поведінкової терапії в лікуванні дітей із ожирінням. Матеріали та методи. Впродовж одного року під спостереженням перебувало 57 дітей віком 7–12 років з ожирінням, які були рандомізовані в дві групи: основну (інтервенційна) — 34 особи (I) та порівняння — 23 особи (II). Діти I групи включені в програму сімейного поведінкового лікування, що полягала в гіпокалорійному харчуванні, контролі за сімейним середовищем та дозованому контрольованому фізичному навантаженні. Ліпідний спектр крові вивчався за рівнем загального холестерину (ЗХС), тригліцеридів (ТГ), холестерину ліпопротеїнів низької (ХС ЛПНЩ) і високої щільності (ХС ЛПВЩ). Результати. У дітей з ожирінням як систолічний (САТ), так і діастолічний арте­ріальний тиск (ДАТ) був підвищений (становив у середньому 125,9 ± 0,9 мм рт.ст. i 66,9 ± 1,2 мм рт.ст. відповідно), також виявлено зростання концентрації ЗХС, ТГ, ХС ЛПНЩ. Через рік після проведення сімейної поведінкової терапії ІМТ у дітей з ожирінням знизився з 26,8 до 25,1 кг/м2, міжгрупові зміни САТ та ДАТ були статистично значущі (I група: до програми САТ становив 124,9 ± 0,8 мм рт.ст., після — 118,9 ± 0,9 мм рт.ст., р < 0,05; ДАТ — 65,7 ± 1,2 мм рт.ст. і 62,1 ± 1,0 мм рт.ст. відповідно, р < 0,05; II група: до програми САТ був 125,1 ± 0,7 мм рт.ст., після — 126,9 ± 0,8 мм рт.ст., р > 0,05; ДАТ — 66,6 ± 1,1 мм рт.ст. і 67,7 ± 1,2 мм рт.ст. відповідно, р > 0,05). Також відбулися достовірні зміни в ліпідному спектрі крові: рівень ЗХС знизився в 0,87 разa, ТГ — у 0,94 разa, при тенденції до зниження ХС ЛПНЩ та підвищення ХС ЛПВЩ. Висновки. Полікомпонентна сімейна поведінкова терапія є ефективною щодо зниження індексу маси тіла дітей з ожирінням. Отримані результати вказують на необхідність застосування запропонованої лікувальної програми в клінічній практиці.
NOVEL UV SPECTROSCOPIC METHOD FOR QUANTIFICATION OF CAFFEINE IN MARKETED ENERGY DRINKS
Authors: SRI K. BHAVYA , HEMA B. , SUMAKANTH MOGILI 
Published: March 2023

Objective: This study is performed to quantitatively estimate caffeine in marketed energy drinks by using UV-Visible spectroscopic method.
Methods: This experiment was performed on various soft drinks and energy drinks available in the local market of India to determine the caffeine concentration. The quantitative method used was simple, easy UV-Visible spectrophotometric method by using carbon dichloromethane as diluent at 274 nm. UV-Vis spectroscopy is an analytical technique that measures the amount of discrete wavelengths of UV or visible light that are absorbed by or transmitted through a sample in comparison to a reference or blank sample.
Results: Among all the samples i.e. soft or energy drinks taken for this experiment sample 1 has low concentration of caffeine and the highest concentration was observed in sample 3.
Conclusion: Caffeine in an energy drink provides a stimulant effect, it gives energy. At lower levels, as it’s typically used in soft drinks, it has less of a stimulant effect and is used mainly for its taste profile. However the concentration of caffeine should be within the limits specified. Excessive consumption of caffeine may lead to anxiety, caffeine dependence, increased urination, and may cause insomnia. Energy drinks can contain high levels of caffeine but are unlikely to be hazardous unless consumed with alcohol. This research is very important analytical process to safeguard the well being of people who are unaware to adverse effects of caffeine.
Uji Aktivitas Antioksidan Dari Akar Kancil (Smilax zeylanica L.)
Authors: Asyhar Rayandra , Yulianika Nanda 
Published: March 2023

[Antioxidant Activity Test of the Roots of the Mouse Deer (Smilax zeylanica L.)]
Akar kancil (Smilax zeylanica L.) merupakan salah satu tanaman yang banyak digunakan oleh Suku Anak Dalam (SAD) sebagai obat-obatan tradisional. Pada penelitian ini digunakan sampel berupa bagian akar dari tanaman akar kancil, karena bagian ini yang banyak digunakan oleh Suku Anak Dalam (SAD). Pada penelitian ini digunakan tiga fraksi yaitu fraksi metano,etil asetat dan n-heksan. Hasil yang didapatkan dari proses ini adalah ketiga fraksi positif mengandung senyawa golongan flavonoid dan tanin. Kemudian dilakukan uji aktivitas antioksidan menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil). Diketahui bahwa aktivitas antioksidan fraksi metanol, etil asetat dan n-heksan yang dinyatakan dengan nilai IC50Â berturut-turut yaitu 22,97 ppm, 76,5 ppm dan 79,43 ppm sehingga termasuk antioksidan kuat. Selanjutnya dilakukan karakterisasi menggunakan spektrofotometer UV-Vis dan FT-IR untuk fraksi dengan aktivitas antioksidan tertinggi yaitu fraksi metanol. HasilÂ interpretasi spektra UV-Vis dan FT-IR fraksi metanol diduga merupakan senyawa yang termasuk golongan flavonoid dan tanin.
IMMUNOTHERAPY WITH LOW DOSE IL-2/CD25 PREVENTS BETA CELL DYSFUNCTION AND DYSGLYCEMIA IN PREDIABETIC NOD MICE
Authors: Qureshi Farhan M. , Panzer Julia K. , Põder Janika , Malek Thomas R. , Caicedo Alejandro 
Published: March 2023

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<p>Low-dose IL-2 is a promising immunotherapy in clinical trials for treating type 1 diabetes. A new IL-2 analog, IL-2/CD25 fusion protein, has been shown to more efficiently delay or prevent diabetes in NOD mice by expanding the population of activated regulatory T cells. This therapy is intended for use before clinical diagnosis, in the early stages of type 1 diabetes progression. During this prediabetic period, there is a chronic decline in beta cell function that has long-term implications for disease pathogenesis. Yet, to date, the effects of IL-2/CD25 on beta cell function have not been evaluated. In this study we treated prediabetic NOD mice with low-dose mouse IL-2/CD25 over 5 weeks and determined its impact on beta cell function. This treatment limited the progressive impairment of glucose tolerance and insulin secretion typical of the later stages of prediabetes. Intracellular Ca2+ responses to glucose in beta cells became more robust and synchronous, indicating that changing the local immune cell infiltrate with IL-2/CD25 preserved beta cell function even after treatment cessation. Our study thus provides mechanistic insight and serves as a stepping stone for future research using low-dose IL-2/CD25 immunotherapy in patients.</p>
Peningkatan Eksistensi Pengrajin Batik Tulis Lampung dengan Inovasi Produk Ecoprint Pewarna Alami Untuk Mendukung Produk Ecolabel di Kemiling, Bandar Lampung
Authors: Utami Herti , Darni Yuli , Lesmana Donny 
Published: March 2023

Pengrajin batik di Bandar Lampung, khususnya di daerah Pinang Jaya, kecamatan Kemiling, terdapat beberapa kelompok UKM batik salah satunya adalah As Syafa Batik yang diketuai oleh Sulastri Oktavia. Hasil penjualan kain batik tulis ini menurun selama pandemi Covid 19, yang terjual hanya 1-2 lembar kain batik selama sebulan, bahkan kadang tidak laku sama sekali. Permasalahan yang dihadapi oleh pengrajin adalah adalah penurunan penjualan sebagai dampak dari pandemi Covid-19. Solusi yang ditawarkan untuk mengatasi masalah ini memberikan pelatihan untuk inovasi produk dengan pelatihan membuat ecoprint.
Pengembangan inovasi produk dengan pelatihan dan pendampingan terkait peningkatan nilai jual produk ecolabel dan kualitas produk kain ecoprint dan khususnya pada proses pewarnaan kain dengan pewarna alami telah dilakukan oleh Tim pelaksana dan ini adalah satu solusi yang ditawarkan untuk mengatasi permasalahan UKM batik. Pada kegiatan pelatihan dan praktek pembuatan ecoprint sebagai produk ecolabel ditunjang dengan pemberian alat-alat dan bahan kepada mitra As Syafa Batik untuk menunjang kegiatan ini. Alat-alat seperti klakat atau kukusan untuk mengukus kain, serta bahan kain serat alami, bahan untuk daun dan pewarna alami telah diberikan untuk menunjang praktek pembuatan kain ecoprint. Selain pelatihan dan praktek tentang pembuatan produk ecoprint, juga dilakukan pengenalan pembuatan pewarna alami sehingga limbah zat warna yang dihasilkan mitra ini lebih ramah lingkungan. Dengan adanya pelatihan dan praktek pembuatan inovasi produk ecoprint yang merupakan produk ecolabel kepada mitra As Syafa batik ini, diharapkan mitra trampil membuat produk kain ecoprint dan mengetahui mengenai produk ecolabel yang lebih ramah lingkungan. Dalam hal ini diharapkan pemasaran produk kain mitra meningkat dengan alternatif produk kain ecoprint yang lebih bervariasi dan keuntungan mitra meningkat.
STATISTICAL METHODS TO IMPROVE THE QUALITY ASSESSMENT OF CLINICAL AUDIT RESULTS
Authors: Gutor Taras , Zimenkovsky Andriy , Mysak Zoriana 
Published: March 2023

The research aims at improving the quality assessment of clinical audit results in Ukraine using the complex of statistical methods and studying statistical methods in foreign reports of the clinical audit and personal experience.
Materials and Methods. The research was performed by analyzing the reports of clinical audit (n=62), held during 2021 by the Healthcare Quality Improvement Partnership. The spectrum of statistical methods was extended by the analysis of the example of a sociological survey of patients (n=405) regarding the quality assessment of medical care. The methods applied in the current study included systemic approach and analysis, structural and logical analysis, correlation and regressive analysis, calculation of relative values.
Results and Discussion. All 100% clinical audit reports, carried out by the Healthcare Quality Improvement Partnership were based on the results of the statistical calculations. The most common method of processing results is the epidemiological statistics (93.5%), ratio of chances/risks (30.6%), probability assessment by Х2 Pearson's method (21.0%). It is noteworthy that for pointing the central tendency almost in half of the cases (46.8 %) the median and the Interquartile Range were used. Complex mathematical methods such as the survival assessment by Kaplan- Meier and method multiple regression were used in 6.5 % та 4.8 % reports, accordingly.
Conclusions. Based on our own experience, we suggested implementation of standardization methods, a detailed correlation and regressive analysis, neuro networks and power analysis into the methodology (technique) of the clinical audit. Implementation of spectrum of evidentially substantiated methods of statistical analysis will allow to increase the evidence level and to deepen the statistical analysis of databases when conducting the clinical audit, аnd therefore, the quality assessment of clinical audit results will increase.
Determinasi Kualitas Pelayanan, Citra Merek dan Harga Terhadap Kepuasan Pelanggan BUMDES Vandofi
Authors: Sari Putri Cahya Amanda , Wijayanti Bayu 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui “Determinasi Kualitas Pelayanan, Citra Merek Dan Harga Terhadap Kepuasan Pelanggan Usaha Bumdes Vandofi, Arjasa”. Penelitian ini menggunakan penelitian kuantitatif, menggunakan kuesioner. Instrument penelitian ini menggunakan non probability sampling serta teknik yang digunakan adalah accidental sampling. Populasi penelitian pada orang-orang yang mengenal atau yang pernah menggunakan jasa penyewaan alat catering Bumdes Vandofi dengan sampel sebanyak 50 orang. Analisis data menggunakan Uji Validitas, Uji Reliabilitas, Uji Normalitas, Uji Multikolonieritas, dan Uji Hipotesis menggunakan program SPSS 25. Hasil penelitian ini menunjukkan bahwa kualitas pelayanan berpengaruh signifikan terhadap kepuasan pelanggan usaha Bumdes Vandofi, Arjasa. Citra Merek tidak berpengaruh signifikan terhadap kepuasan pelanggan usaha Bumdes Vandofi, Arjasa. Harga tidak berpengaruh signifikan terhadap kepusan pelanggan usaha Bumdes Vandofi, Arjasa. Kualitas Pelayanan, Citra merek dan Harga berpengaruh secara simultan terhadap kepuasan pelanggan usaha Bumdes Vandofi, Arjasa
Analisis Faktor-Faktor Yang Mempengaruhi Keputusan Pembelian di Herdacake Bakery dan Cafe Jember
Authors: Atri Rahma Dian Milinia Desi , Ambarkahi Ratih Puspitorini Yekti , Dhamayanthi Wenny , Putra Dhanang Eka , Widjayanthi Lenny 
Published: March 2023

Penelitian ini dilatarbelakangi karena Herdacake Bakery & Cafe Jember merupakan outlet yang baru saja dibuka tetapi mampu menarik konsumen dengan desain tempat yang kekinian atau instragamable dimana dapat dijadikan spot foto dan direkomendasikan banyak orang. Penelitian ini bertujuan untuk menganalisis dan menguji pengaruh kualitas produk, kualitas pelayanan, dan citra merek terhadap keputusan pembelian di Herdacake Bakery & Cafe Jember. Populasi dalam penelitian ini adalah seluruh konsumen yang membeli produk Herdacake Bakery & Cafe Jember dengan pengambilan sampel sebanyak 40 responden. Alat analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda dengan bantuan SPSS 25.00. Hasil penelitian ini menunjukkan bahwa pada uji F variabel kualitas produk, kualitas pelayanan, dan citra merek bersama- sama berpengaruh signifikan terhadap keputusan pembelian di Herdacake Bakery & Cafe Jember. Sedangkan untuk uji t variabel kualitas produk secara parsial berpengaruh signifikan terhadap keputusan pembelian di Herdacake Bakery & Cafe Jember. Variabel kualitas produk merupakan variabel berpengaruh paling dominan terhadap keputusan pembelian di Herdacake Bakery & Cafe Jember.
Hydatid disease of central nervous system, a clinicopathological study of 33 cases
Authors: Din Nasir Ud , Raza Muhammad , Rahim Shabina , Memon Wasim , Ahmad Zubair 
Published: March 2023

Objectives:
Involvement of central nervous system (CNS) by Hydatid cyst is rare comprising 0.5–4% of all hydatid cysts and principally affecting those younger than 20 years, giving rise to cystic masses mostly in the cerebral hemispheres. To report the clinicopathological findings of CNS hydatid cysts, we diagnosed and review the findings of the previous studies.

Materials and Methods:
All cases reported in our Section between January 1, 2001, and June 30, 2022, were included in the study. By searching our files, cases were retrieved, and diagnosis was confirmed. Follow-up was received on telephone. Ethical exemption was obtained.

Results:
Thirty-three cases were diagnosed. Almost all were received from rural areas. There were 17 females and 16 males. Mean and median age were 20 and 19 years, respectively. Over 60% were younger than 20 years of age. All 33 involved the cerebral and cerebellar hemispheres. Seventy six percent were supratentorial while 24% were infratentorial. The most common signs and symptoms included weakness, headaches, and seizures. All appeared as solitary cystic masses on imaging. Almost 67% were clinically suspected to be hydatid cysts. Grossly, thin-walled transparent unilocular or multilocular cysts filled with viscous material were received intact in 52% and in multiple pieces in 48% cases. Intact cysts measured 7 cm on average. All demonstrated typical histology. Of the nine patients whose follow-up was available, one died from unspecified acute surgery related complications. Four patients were asymptomatic at the time of follow-up, whereas four developed recurrent cysts. All eight received albendazole therapy.

Conclusion:
Cerebellum/posterior fossa location was common. Several cases were received in multiple pieces with increased risk of recurrence. Clinicopathological features were similar to those reported in literature. This series will hopefully serve to increase awareness regarding CNS hydatid disease.
MRI of wrist and diffusion tensor imaging of the median nerve in patients with carpal tunnel syndrome
Authors: Naik Suprava , Mahanty Siladitya , Bhoi Sanjeev Kumar , Lahre Yuvraj , Bag Nerbadyswari Deep , Mohakud Sudipta 
Published: March 2023

Objectives:
Diagnosis of carpal tunnel syndrome (CTS) is based on the clinical symptoms and nerve conduction study. Magnetic resonance imaging (MRI) is non-invasive objective tool for assessing the median nerve and carpal tunnel. The purpose of this study was to evaluate MRI changes in patients with CTS, and compare them with healthy subjects.

Materials and Methods:
Forty-three CTS patients and 43 age matched control were included and scanned in a 3T MRI scanner. Cross-sectional areas (CSA) of median nerve were measured at the level of distal radio-ulnar joint level (CSA1), proximal row of carpal bone (CSA2), and hook of hamate (CSA3). Flattening ratio (FR) of median nerve, thickness of flexor retinaculum, median nerve signal intensity, and thenar muscles were assessed. Fractional anisotropy (FA), average diffusion coefficient (ADC), and radial diffusivity (RD) of median nerve of CTS patients were obtained from diffusion tensor imaging (DTI) and compared with those of controls.

Results:
Thirty-three patients (76.7%) were female. Mean duration of the pain was 7.4 ± 2.6 months. The mean CSA1 (13.2 ± 4.2 mm2), CSA2 (12.5 ± 3.5 mm2), and CSA3 (9.2 ± 1.5 mm2) in CTS patients were significantly higher compared to control group: CSA1 (10.15 ± 1.64 mm2), CSA2 (9.38 ± 1.37 mm2), and CSA3 (8.4 ± 0.9 mm2), (P = 0.001 in all). The mean FR of median nerve and thickness of flexor retinaculum were increased in CTS patients. The mean FA was reduced in CTS patients compared to control proximal to carpal tunnel and within the tunnel. Mean ADC and RD values were higher in CTS patients as compared to control for both levels.

Conclusion:
MRI can detect subtle changes in the median nerve and thenar muscles in CTS and may be useful in equivocal cases and to exclude secondary causes of CTS. DTI shows reduced FA and increased ADC and RD in CTS patients.
Insecticide Susceptibility Tests ofAedes taeniorhynchusin Yucatan, Mexico
Authors: Navarrete-Carballo Juan , Chan-Espinoza Daniel , Palacio-Vargas Jorge , González-Olvera Gabriela , Che-Mendoza Azael , Martin-Park Abdiel , Manrique-Saide Pablo 
Published: March 2023

ABSTRACTWe report results of susceptibility tests for Aedes taeniorhynchus from 2 localities of Yucatan State, Mexico, to different insecticides. The Centers for Disease Control and Prevention bottle bioassays were performed using the active ingredients of 3 pyrethroids, 2 organophosphates, and 1 carbamate: permethrin (15 μg/ml), deltamethrin (10 μg/ml), alpha-cypermethrin (10 μg/ml), malathion (50 μg/ml), chlorpyrifos (85 μg/ml), and bendiocarb (12.5 μg/ml). The mortality recorded at the diagnostic time of exposure (30 min) was 100% with all insecticides evaluated and for both populations. These results suggest complete susceptibility to the 3 chemical groups generally used for urban Ae. aegypti mosquito control.
Aedes aegyptiin Georgia, USA
Authors: Kelly Rosmarie , Nguyen Thuy-Vi Thi , Graham Kenna 
Published: March 2023

ABSTRACTAedes aegypti, commonly known as the yellow fever mosquito, is closely linked to the human environment and directly influenced by the availability of water-holding containers for oviposition and larval development. The discovery of an active population of Ae. aegypti in Columbus, GA, was deemed an important public health matter, and extensive surveillance was initiated to monitor, delineate, and suppress this population.
Aedes pertinax,Anopheles perplexens,Culex declarator, andCx. interrogator: An Update of Mosquito Species Records for Charlotte County, Florida
Authors: Kovach Beth C. , Reeves Lawrence E. , Domingo Candelaria , L'heureux Sydney N. , Burger Gavriel V. , Schermerhorn Scott D. , Riles Michael T. 
Published: March 2023

ABSTRACTUnderstanding the geographic occurrence of mosquito species is an important element to addressing public health and nuisance mosquito-related issues, particularly as changing climates and increased global connectivity is likely to facilitate changes in the distribution of mosquitoes and other species. In Charlotte County, FL, routine surveillance of mosquito species for public health in 2019–21 identified 4 mosquito species not previously documented in the county. Aedes pertinax, Anopheles perplexens, Culex declarator, and Cx. interrogator adults were collected and verified to species level. Aedes pertinax and Cx. declarator and were collected in 2019, whereas An. perplexens and Cx. interrogator were documented from collections in 2021. All 4 species were initially visually identified by external morphology and confirmed by sequencing the DNA barcoding region of the cytochrome c oxidase subunit I gene. Apart from native An. perplexens, in which only 1 specimen has been confirmed to date, the 3 newly documented nonnative species are now recognized throughout the county.