bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusive Early Childhood Education: To What Extent is Inclusion of Academic Benefit to ECD Learners with Intellectual and Learning Disabilities?
Authors: Pangeti Fungayi Fortune , Mapolisa Tichaona , Chisaka Bornface Chenjerai 
Published: April 2023

The extent to which inclusion is of academic benefit to ECD learners with intellectual and learning disabilities is a topical subject for discussion among educators. The participatory action research study was conducted to find out the extent to which the inclusive education practices at an ECD Centre in Harare were of academic benefit for learners with intellectual and learning disabilities. Data were generated from seven learners with intellectual and learning disabilities, teachers and parents of the learners, university lecturers and from the school administrator. Our action research cycles included teaching in the respective learner’s classes, as well as observations made on the playground. For triangulation we combined data generated from our interviews with key participants, participant and non-participant observations, and from document analyses. The NVivo data management system was used to code data into emergent themes. We concluded that although the school was open to inclusion, the teachers were not well trained for it, and that the learners could have benefited from a more diverse curriculum to compensate for their academic challenges. Our recommendations following the research were that both the parent government ministry, and the school administration could do more for the teachers in terms of training in inclusive education practices. We also recommended that for future research opportunities, the study could be extended to include an investigation into inclusive education practices as they relate to learners with intellectual disabilities as they transition from primary school to secondary school.
Crystal structure of (glycinto-κ
2
O,N
′)-[5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ
4
N,N
′,N
″,N
‴]nickel(II) perchlorate monohydrate C18H42ClN5NiO7
Authors: Zhang Zu-Jiao , Ou Guang-Chuan 
Published: April 2023

Abstract
C18H42ClN5NiO7, orthorhombic, Pca21 (no. 29), a = 14.270(3) Å, b = 9.918(2) Å, c = 17.603(4) Å, V = 2491.4(10) Å3, Z = 4, R

gt
(F) = 0.0382, wR

ref
(F
2) = 0.0861, T = 173(2) K.
Egy ikigai elemekkel bővített „legvágyottabb én” típusú online intervenció hatásvizsgálata
Authors: Pál László , Sebestyén Nóra 
Published: April 2023

Háttér és célkitűzésekAz utóbbi években a pozitív pszichológiai intervenciók száma nemzetközi viszonylatban növekszik. Magyarországon, a szemlélet népszerűsége ellenére, empirikusan igazolt publikált hatásvizsgálatok nem jellemzőek. Jelen vizsgálat célja egy ikigai elemekkel bővített „legvágyottabb én” típusú intervenció hatásvizsgálata egyetemista mintán.MódszerA kutatás egy online megvalósuló randomizált kontrollált vizsgálat volt aktív kontrollcsoporttal, összesen 151 egyetemi hallgató részvételével. A kísérleti csoport (n = 78) egy 20 perces online írásos aktivitásban vett részt, mely egy „ikigai” (személyes erőforrások mobilizálása) és egy „legvágyottabb én” gyakorlatból (vágyott jövőbeli én elképzelése a személyes, szociális és tanulmányi/szakmai célokkal kapcsolatban) állt. A kontrollfeltétel (n = 73) hasonló elrendezést tartalmazott, csupán tartalmában tért el a kísérleti helyzettől (napi tevékenységeket részletező gyakorlatok).EredményekEredményeink alapján a 20 perces intervenció szignifikáns mértékben növelte az optimizmus, az önértékelés és az énhatékonyság szintjét, valamint eredményes volt a szorongás csökkentésében.KövetkeztetésekA kutatás hazánkban először igazolta empirikusan a legvágyottabb én típusú intervenció kedvező hatását. Egyrészt támogatja a nemzetközi vizsgálatok eredményeit, másrészt hozzájárul a szakirodalomhoz azáltal, hogy kibővíti a legvágyottabb én beavatkozások hatáskörét, mivel az optimizmuson kívül a pszichológiai tőke egyéb elemeit is vizsgálta (önértékelés, énhatékonyság). A kutatás továbbá jelentős gyakorlati relevanciával bír; az ikigai elemekkel bővített legvágyottabb én típusú intervenciók hatékonyan támogathatják a felsőoktatási diáktanácsadók munkáját, illetve segíthetik a középiskolai pályaválasztással kapcsolatos foglalkozásokat.
El teletrabajo como modalidad para épocas de transformaciones
Authors: Franco-López Jorge , Uribe-Gómez Julián Alberto 
Published: April 2023

El teletrabajo es una modalidad laboral que se desarrolla utilizando las tecnologías de la información y comunicaciones, como respuesta flexible a los nuevos retos del mercado de trabajo. Se tuvo como objetivo efectuar un análisis de variables que influyen en el teletrabajo como modalidad laboral, al interior de un conglomerado empresarial que reúne 22 organizaciones de servicios que incursionan en esta práctica en una economía emergente. A nivel metodológico la investigación fue de tipo descriptiva y correlacional, con un modelo mixto, se utilizó un sistema categorial que reunió 6 variables: teletrabajo, ventaja competitiva; herramientas tecnológicas; productividad; cultura organizacional; sostenibilidad empresarial, y 17 subvariables. La información primaria se obtuvo desde el pacto del teletrabajo, el análisis de los datos permitió construir un modelo de regresión lineal múltiple en el cual el coeficiente de determinación fue del 99,4%, y un grado de coherencia entre la variable teletrabajo con respecto de 16 subvariables independientes. Se produjo un modelo el cual permitió conocer el grado de coherencia entre la variable dependiente teletrabajo con respecto de las 5 variables independientes indicadas.
Study of total antioxidant capacity of red raspberry (Rubus idaeous L.) shoots
Authors: Maslov Olexander Yu. , Komisarenko Mykola A. , Golik Mykola Yu. , Kolisnyk Sergii V. , Altukhov Alexander A. , Baiurka Sergii V. , Karpushina Svetlana A. , Tkachenko Oksana , Iuliia Kolisnyk 
Published: April 2023

BACKGROUND: Today, cardiovascular, oncological, and neurodegenerative diseases are the main causes of death in the world, according to official World Health Organization (WHO) statistics. Antioxidants are used to treat and prevent these diseases. In order to develop optimal technology for obtaining drugs based on plant extracts with antioxidant action, it is necessary to determine the total antioxidant capacity of raspberry shoots.OBJECTIVES: The study aimed to determine the total antioxidant capacity of red raspberry shoots, study the content of biologically active substances (BAS), and the antioxidant activity of red raspberry shoot extracts obtained during subsequent exhaustive extraction.METHODS: The number of phenolic compounds, catechins, flavonoids, and hydroxycinnamic acids was determined by a spectrophotometric analysis method, whereas organic acids were determined by the alkalimetric method in red raspberry shoot extracts; the antioxidant activity of obtained extracts was evaluated by potentiometric method. RESULTS: The total antioxidant capacity of red raspberry shoots was 164.12 mmol-equiv./m dry weight, the sum of the total content of phenolic compounds was 24.40 mg gallic acid (GA)/mL, catechins – 21.36 mg epigallocatechin-3-O-gallate (EGCG)/mL, flavonoids – 0.77 mg rutin (R)/mL, hydroxycinnamic acids derivatives – 2.56 mg chlorogenic acid (ChA)/mL and organic acids – 1.88 mg citric acid (CA)/mL in red raspberry shoot extracts obtained during subsequent exhaustive extraction. The analysis showed that there is a very high positive correlation between antioxidant activity and total phenolic compounds, catechin, flavonoid, hydroxycinnamic acids derivatives, and organic acids content in red raspberry shoot extracts. CONCLUSIONS: Total red raspberry shoots' antioxidant capacity has been determined. The study results can be used to develop optimal technology for obtaining drugs based on the extract of red raspberry shoots, which has an antioxidant effect.
Comparison of TRAP (triceps reflecting anconeus pedicle approach) v/s olecranon osteotomy approach for treatment of intercondylar fracture humerus
Authors: Goyal Roshan Lal , Sharma D K , Banodha Laxman 
Published: April 2023

Distal humerus fractures constitute 2 to 7% of all the elbow fractures. Young males are most commonly affected due to high energy trauma and secondly seen in elderly women due to osteoporosis. Due to complex anatomy and neurovascular network nearby, the treatment is very difficult. Anatomical reconstruction is the key for successful functional outcome. We compared the TRAP and olecranon osteotomy approach for the management of intraarticular fractures of the humerus in terms of functional, clinical and radiological outcome. The study was conducted in the Department of Orthopaedics & Traumatology, MGM Medical College and MY Hospital, Indore from August 2019 to August 2021 on 30 patients with intra-articular fractures of humerus. 15 patients were treated with olecranon osteotomy and 15 patients were treated with TRAP approach, on patients fulfilling all the inclusion, but none of the exclusion criteria. The functional outcome was measured using Mayo Elbow Performance Score (MEPS) and radiographs were used for evaluating the bone union time.There was a male predominance. Assault, fall and road traffic accidents were the modes of injury. 13-B2, 13-C1 and 13-C3 were commonly seen fracture types. Mean MEPS was significantly better in TRAP (P&#60;0.05) and full triceps strength was achieved in 86.7% patients by 3 months in TRAP and by 6 months in olecranon osteotomy group. The mean blood loss and duration of surgery was significantly longer in olecranon group (P&#60;0.05). The bone union time and hospital stay were comparable between the groups (P&#62;0.05). 73.3% patients of TRAP and 64.3% patients of olecranon osteotomy group achieved excellent outcome by 6 months.TRAP approach is comparatively better than osteotomy approach. Both the methods provide a stable fracture fixation, but complications are more in osteotomy in comparison to TRAP and we found TRAP to be functionally better.: TRAP-triceps reflecting anconeus pedicle approach, MEPS-Mayo Elbow Performance Score, DASH-disabilities of the arm, shoulder and hand, POP-plaster of Paris
Comparison of orthopedic fractures operated during the COVID-19 pandemic with the pre-pandemic period
Authors: Boz Mehmet , Güzel İsmail 
Published: April 2023

The duration of staying at home increased during the coronavirus pandemic due to the people’s instincts to protect themselves and lock down. The aim of this study is to compare the changes in orthopedic trauma patients operated in the same term of the coronavirus disease 2019 (Covid-19) pandemic and pre-pandemic periods.This retrospective study was conducted with data obtained from Malatya Training and Research Hospital and compared the Covid-19 pandemic and pre-pandemic period. Orthopedic trauma patients who were operated in the Orthopedics and Traumatology clinic between 24 March-1 July, 2020 and 24 March-1 July, 2019 were included in the study. The patients’ demographic characteristics (age and sex) and trauma-related information (type and site of the fracture, osteoporotic fracture, injury mechanism and treatment modality) were compared between two groups.There were statistically significant differences between the groups in terms of the rates of osteoporotic fractures. We are in the opinion that arrangements for individuals with a high risk of osteoporotic fracture should be made where they can practice physical activities such as walking and exercising at certain times, when there is a lock down during the pandemic. Additionally, detailed studies on traumas that may occur due to increasing stress during such pandemics should be conducted. A total of 439 patients were included in the study. The traffic accidents were significantly lower in the pandemic group than the pre-pandemic group, simple falls were significantly higher in the pandemic group than the pre-pandemic group (P&#60;0.05). Additionally, fractures induced by hitting a hard surface and gunshot wounds significantly increased in the pandemic group compared to the pre-pandemic group (P&#60;0.05).
Low grade central osteosarcoma transforming to high grade sarcoma – Clinical implications and brief review of literature !
Authors: Yadav Arun Kumar , Tewari Shatakshee , Singh Anshul , Misra Vatsala 
Published: April 2023

Low grade central osteosarcoma (LGCO) are rare intramedullary bone tumours of adolescents and young adults with an excellent prognosis. They have a predilection for long bones around the knee joint, but cases have been reported in long bones of arm, tarsals and flat bones of jaw, ribs and scapula as well. Their transformation to high grade sarcomas are rarely seen. We report a case of an 16 years female who presented with complaints of progressive pain in the lower thigh 2 years back. Her x-ray suggested a simple bone cyst in distal femur, following which wide excision of the cyst was done. Histopathology however showed features of LGCO. The patient was apparently alright in the follow up period until 9 months ago when the patient had a recurrence of swelling accompanied with pain at the same site leading to difficulty in walking. This time her X-ray showed neoplastic changes after which the tumor was excised. On microscopy, areas of high grade sarcoma with soft tissue extension were seen predominantly. This case is being reported to make the clinicians and diagnosticians aware of the rare but highly significant implication of transformation of LGCO to high grade tumors as it carries a guarded prognosis and calls for a different treatment strategy compared to conventional LGCO. Low grade central osteosarcoma (LGCO) are rare intramedullary bone tumors seen in adolescents and young adults. It bears an excellent prognosis. We present a case report on LGCO showing transformation to a high grade sarcoma that radically changes its prognosis as well as calls for a different treatment strategy.
Effect of Vaccinium Arctostaphylus Plant Extract on the Histopathological Alterations of Cisplatin on Testicular Tissue
Authors: Ghaffarian Ali , Ebrahimi Kalan Abbas , Afshari Fatemeh , Alipanah-Moghadam Reza 
Published: April 2023

Introduction: The destructive effects of anticancer drugs such as cisplatin are well known. In recent years, it has been found that medicinal plants have a fundamental role in protecting the damage caused by drug. The purpose of this study was to investigate the effects of vaccinium arctostaphylus plant one of the prevalent materials in traditional medicine in improving the disorders caused by cisplatin in testicular tissue.
Methods: In this research, forty rats were divided into 5 groups (G) (n=8) based on administration cisplatin and extract of vaccinium arctostaphylus. In G1 physiological serum was injected and in G2 only cisplatin was administrated. In G3, G4, and G5 Arctostaphylus vaccinium extract with a concentration of 100, 200, and 300 mg/kg along with a single dose of cisplatin were administrated. After 24 hours, the rats were sacrificed, and then testis was isolated and subjected to histopathological evaluation with t-test and one-way ANOVA test on Prism-GraphPad 9.
Results: Our results showed that in the G2 group, the number of spermatogonial cells was reduced compare with G1 (P=0.01); As well as the thickness of the germinal epithelium and the diameter of the seminiferous tubules were reduced partially. In G3 and G4 groups in comparison with G2, the germinal epithelium was improved (P=0.02). The preservation of spermatogonial cells in G3 significantly increased compare with G2 (P=0.01).
Conclusion: According to the results, Arctostaphyllus vaccine as a native plant in defined dosages has a significant effect on improving cisplatin-induced disorders in the germinal epithelium and the number of spermatogonial cells preservation.
Microbiota: its contribution to carcinogenesis and immunity in the lungs
Authors: Buslaev V. Yu. , Minina V. I. , Matskova L. V. 
Published: April 2023

Microbiota (an assembly of bacteria, protists / archaea, fungi, and viruses inhabiting a human body) is currently of great interest for science. It is determined by an association between changes in microbiota composition and malignant transformation in different organs. Lungs have long been considered sterile or free from bacteria; however, due to development of next-generation sequencing, this statement has been reconsidered. The metagenomic approach allowed to identify microorganisms at molecular level both in healthy lung tissues and in malignant ones.The next stage of research is investigation of the effects of microbiota on homeostasis and immune stability in the lungs. The analysis of lung microbiota based on 16S rRNA gene sequencing revealed that microbiota of healthy lungs is mainly presented by bacteria of the phyla Bacteroidetes, Firmicutes, Proteobacteria, and Fusobacteria. In lung cancer, an increase in the number of bacteria of some certain genera and a decrease in microbiota diversity on the whole are noted. Dysbiosis facilitates reproduction of pathogens and development of lung diseases. It was detected that under normal conditions, microbiota maintains resistance of the lungs to bacterial colonization and plays a crucial role in providing a balanced immune response in this organ.
An extract from the culture of a thermophilic <i>Staphylococcus aureus</i> strain suppresses allergic inflammation in the airways <i>in vivo</i> and degranulation of mast cells and basophils <i>in vitro</i>
Authors: Kalyuzhin O. V. , Proskurina O. V. , Sukhanova S. A. , Novikova N. V. , Kolganova N. A. 
Published: April 2023

Aim. To study the anti-allergic effects of ruzam, an extract from the culture of a thermophilic Staphylococcus aureus strain, in an in vivo model of asthma and its influence on degranulation of mast cells and basophils in vitro.Materials and methods. Allergic asthma in guinea pigs was reproduced by two intraperitoneal injections of ovalbumin followed by a series of inhalations of this antigen for 1.5 months. Ruzam (6 μg / kg) or a reference drug (sodium cromoglycate, 3 mg / kg) was administered daily via a nebulizer during the last 6 days of immunization. One day after completion of inhalations with ovalbumin and compared drugs, changes in the airways were assessed using cytological, morphometric, and histologic methods. Rabbit blood basophils and rat peritoneal mast cells were used to determine the effect of ruzam on IgE-independent degranulation induced by the compound 48 / 80 in vitro. The effect of ruzam was compared with that of hydrocortisone hemisuccinate. Basophils from the blood of ovalbumin-sensitized guinea pigs were used to evaluate the effect of the drug on IgE-dependent degranulation induced by ovalbumin. Granules of mast cells and basophils were detected by alcian blue staining to calculate the degranulation index.Results. In the asthma model, ruzam reduced the degree of airway obstruction by increasing the bronchoalveolar lavage volume returned and suppressed neutrophilic and eosinophilic inflammation, while mobilizing other effector cells of the anti-pathogen immunity (lymphocytes and macrophages). Ruzam has proven to have a stronger anti-allergic effect than sodium cromoglycate by several parameters. At concentrations of 8.4–840 μg / ml, ruzam inhibited degranulation of mast cells and basophils, induced by the compound 48 / 80, equally to hydrocortisone hemisuccinate (10–3 M). At concentrations of 280 and 420 μg / ml, ruzam dose-dependently inhibited ovalbumin-induced degranulation of basophils in sensitized guinea pigs.Conclusion. The anti-allergic effect of ruzam was confirmed in test systems in vivo and in vitro. We speculate here that the TLR2 signaling pathway may be involved in biological and pharmacological effects of this drug.
Diagnosis of sentinel lymph nodes in patients with cancer of the larynx and laryngopharynx using a new radiopharmaceutical based on technetium-99m-labeled gamma aluminum oxide
Authors: Medvedeva A. A. , Chernov V. I. , Bragina O. D. , Zeltchan R. V. , Choynzonov E. L. , Chizhevskaya S. Yu. , Rуbina A. N. , Gol’dberg A. V. , Сheremisina O. V. 
Published: April 2023

Аim. To study the possibility of using a radiopharmaceutical based on aluminum oxide labeled with 99mТс ([99mТс]-Al2O3) for the diagnosis of sentinel lymph nodes (SLN) in tumors of the larynx and laryngopharynx in comparison with a phytate colloid ([99mTc]-phytate colloid).Materials and methods. The study included patients with cancer of the larynx and laryngopharynx (T2–4N0M0) (n = 54). In the prospective group (n = 30), [99mТс]-Al2O3 was used as a radiopharmaceutical, in the retrospective group (n = 24), [99mТс]-phytate colloid was used. All radiopharmaceuticals were introduced endoscopically into the submucosal space along the periphery of the tumor. After 18 hours, single-photon emission computed tomography (SPECT) and intraoperative SLN detection were performed.Results. In the retrospective group, SLNs were detected in 20 out of 24 patients. A total of 32 lymph nodes were identified in the retrospective group. The median number of detected lymph nodes in one patient was 1.3 [0–3], the intensity of the radiopharmaceutical uptake on scintigrams was 2.2 [0.7–8.1], intraoperatively – 4 [1.6–9.0]. In the prospective group, [99mTc]-Al2O3 uptake in the lymph nodes of the neck was determined in 27 patients (90%); in3 patients, SLNs were not visualized. A total of 57 lymph nodes were identified (in 27 patients). The median number of visualized SLNs was 1.5 [0–5], the intensity of [99mТс]-Al2O3 uptake according to SPECT and intraoperative detection was 4.8 [0.7–19.4] and 6 [1.1–22.0], respectively.Conclusion. The most significant advantage of using [99mТс]-Al2O3 as a radiopharmaceutical is its high uptake in SLNs, which leads to an increase in the sensitivity of the method as a whole up to 90 versus 83% when using [99mTc]-phytate colloid.