bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2‐ and IgE/FcεRI‐mediated events
Authors: Baldo Brian A. 
Published: July 2023

AbstractMRGPRX2, a novel Gaq‐coupled human mast cell receptor, mediates non‐immune adverse reactions without the involvement of antibody priming. Constitutively expressed by human skin mast cells, MRGPRX2 modulates cell degranulation producing pseudoallergies manifesting as itch, inflammation and pain. The term pseudoallergy is defined in relation to adverse drug reactions in general and immune/non‐immune‐mediated reactions in particular. A list of drugs with MRGPRX2 activity is presented, including a detailed examination of three important and widely used approved therapies: neuromuscular blockers, quinolones and opioids. For the clinician, the significance of MRGPRX2 is considered as an aid in distinguishing and ultimately identifying specific immune and non‐immune inflammatory reactions. Anaphylactoid/anaphylactic reactions, neurogenic inflammation and inflammatory diseases with a clear or strongly suspected association with MRGPRX2 activation are examined. Inflammatory diseases include chronic urticaria, rosacea, atopic dermatitis, allergic contact dermatitis, mastocytosis, allergic asthma, ulcerative colitis and rheumatoid arthritis. MRGPRX2‐ and allergic IgE/FcεRI‐mediated reactions may be clinically similar. Importantly, the usual testing procedures do not distinguish the two mechanisms. Currently, identification of MRGPRX2 activation and diagnosis of pseudoallergic reactions is generally viewed as a process of exclusion once other non‐immune and immune processes, particularly IgE/FcεRI‐mediated degranulation of mast cells, are ruled out. This does not take into account that MRGPRX2 signals via β‐arrestin, which can be utilized to detect MRGPRX2 activation by employing MRGPRX2 transfected cells to assess MRGPRX2 activation via two pathways, the G‐protein‐independent β‐arrestin pathway and the G‐protein‐dependent Ca2+ pathway. Testing procedures, interpretations for distinguishing mechanisms, patient diagnosis, agonist identification and drug safety evaluations are addressed.
Investigating associations between parent engagement and toddlers' mathematics performance
Authors: Silver Alex M. , Swirbul Mackenzie , Tamis‐LeMonda Catherine S. , Cabrera Natasha , Libertus Melissa E. 
Published: July 2023

AbstractEarly mathematics skills relate to later mathematics achievement and educational attainment, which in turn predict career choice, income, health and financial decision‐making. Critically, large differences exist among children in early mathematics performance, with parental mathematics engagement being a key predictor. However, most prior work has examined mothers' mathematics engagement with their preschool‐ and school‐aged children. In this Registered Report, we tested concurrent associations between mothers' and fathers' engagement in mathematics activities with their 2‐ to 3‐year‐old toddlers and children's mathematics performance. Mothers and fathers did not differ in their engagement in mathematics activities, and both parents' mathematics engagement related to toddlers' mathematics skills. Fathers' mathematics engagement was associated with toddlers' number and mathematics language skills, but not their spatial skills. Mothers' mathematics engagement was only associated with toddlers' mathematics language skills. Critically, associations may be domain‐specific, as parents' literacy engagement did not relate to measures of mathematics performance above their mathematics engagement. Mothers' and fathers' mathematics activities uniquely relate to toddlers' developing mathematics skills, and future work on the nuances of these associations is needed.
Are curiosity and situational interest different? Exploring distinct antecedents and consequences
Authors: Shin Dajung Diane , Park Yoonah , Lee Minhye , Kim Sung‐il , Bong Mimi 
Published: July 2023

AbstractBackgroundA controversy over the distinction between curiosity and situational interest has recently resurfaced. Nonetheless, empirical research comparing the two is noticeably lacking.AimsWe attempted to fill this gap and provide much‐needed evidence of the distinction between curiosity and situational interest by examining the antecedents and consequences of the two constructs.MethodsWe assessed enjoyment, novelty, uncertainty and surprise as potential antecedents and information seeking, individual interest, career intention and achievement as potential outcomes of curiosity and situational interest among 219 Korean sixth graders in the domain of science.ResultsOf the hypothesized antecedents, enjoyment during science class related most strongly to students' situational interest in science, whereas novelty in science class related most strongly to students' science curiosity. Uncertainty and surprise in science class related to only science curiosity and not situational interest in science. Among the outcomes considered, situational interest in science related to only students' individual interest in science. In comparison, science curiosity related significantly to all science outcomes measured in this study. Science curiosity also significantly mediated the relationships between the antecedents and outcomes in science.ConclusionsTogether, these results support the distinction between curiosity and situational interest and suggest different ways to promote each motivation construct depending on desired outcomes in the science classroom.
Intangible rewards versus tangible rewards in gamified online learning: Which promotes student intrinsic motivation, behavioural engagement, cognitive engagement and learning performance?
Authors: Xiao Ya , Hew Khe Foon Timothy 
Published: July 2023

AbstractGamification has often been used to stimulate learner engagement via intangible rewards, such as virtual points and virtual badges, rather than material goods or benefits. However, not all learners value such intangible rewards; some express their desire to redeem intangible rewards for utilitarian resources or benefits. Although tangible rewards have long been considered a key gamification mechanism in commercial loyalty programs, few studies have explicitly explored its effectiveness in the context of gamified education. To address this gap, the present study used a randomized controlled trial approach to examine the effects of tangible rewards that are redeemed through intangible rewards on students' intrinsic motivation, behavioural and cognitive engagement, and learning performance in a fully online gamified flipped class. Each student was randomly assigned either to the tangible rewards group (EG = 28) or the intangible rewards group (CG = 29). The students in EG significantly outperformed those in CG in terms of intrinsic motivation, behavioural engagement, cognitive engagement and learning performance in the final exam. The results provided practical implications for instructors who plan to use tangible rewards in their gamified classes.Practitioner notesWhat is already known about this topicFully online learning often suffers from a lack of student engagement.Gamification is often used to stimulate learner engagement via intangible rewards (eg, virtual points and badges) that do not contain any utilitarian benefits outside the gamified system.Not all learners value intangible rewards over time—instead, they desire to convert the intangible badges or points into more utilitarian benefits/resources.What this paper addsThis study conducted a randomized controlled experiment to compare the effects of redeemable tangible rewards and intangible rewards on student intrinsic motivation, behavioural engagement, cognitive engagement and learning performance.The tangible rewards group significantly outperformed the intangible rewards group in all aspects.Implications for practiceUsing tangible rewards is better than merely using intangible rewards in gamified learning.Practitioners should link tangible rewards to a standard of performance.Practitioners should also set a specific and moderately challenging redemption goal.
K‐Plus anticlustering: An improved k‐means criterion for maximizing between‐group similarity
Authors: Papenberg Martin 
Published: July 2023

AbstractAnticlustering refers to the process of partitioning elements into disjoint groups with the goal of obtaining high between‐group similarity and high within‐group heterogeneity. Anticlustering thereby reverses the logic of its better known twin—cluster analysis—and is usually approached by maximizing instead of minimizing a clustering objective function. This paper presents k‐plus, an extension of the classical k‐means objective of maximizing between‐group similarity in anticlustering applications. K‐plus represents between‐group similarity as discrepancy in distribution moments (means, variance, and higher‐order moments), whereas the k‐means criterion only reflects group differences with regard to means. While constituting a new criterion for anticlustering, it is shown that k‐plus anticlustering can be implemented by optimizing the original k‐means criterion after the input data have been augmented with additional variables. A computer simulation and practical examples show that k‐plus anticlustering achieves high between‐group similarity with regard to multiple objectives. In particular, optimizing between‐group similarity with regard to variances usually does not compromise similarity with regard to means; the k‐plus extension is therefore generally preferred over classical k‐means anticlustering. Examples are given on how k‐plus anticlustering can be applied to real norming data using the open source R package anticlust, which is freely available via CRAN.
Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: Audit of UK pituitary centres
Authors: Papanikolaou Nikoleta , Millar Ophelia , Coulden Amy , Parker Nina , Sit Lee , Kelly Chris , Cox Jeremy , Dhillo Waljit S. , Meeran Karim , Al Memar Maya , Anderson Richard , Rees D Aled , Karavitaki Niki , Jayasena Channa N. 
Published: July 2023

AbstractObjectiveFunctioning gonadotroph adenomas (FGAs) are rare pituitary tumours stimulating ovarian function with potential life‐threatening consequences in women. However, a lack of aggregated clinical experience of FGAs impairs management in affected women. The aim of this study is to present the clinical course of FGA‐induced ovarian hyperstimulation syndrome (OHSS) cases as identified by some of the largest UK pituitary endocrine tertiary centres with a view to increasing awareness and improving diagnosis and management of women with FGA.DesignA retrospective observational study; audit of eight UK regional pituitary centres for cases of FGAs.SettingSpecialist neuroendocrine centres in the United Kingdom.Patients and MeasurementsWomen diagnosed with FGA‐induced OHSS. Description of their clinical course.ResultsSeven cases of FGA were identified in women, all causing OHSS. Mean age was 33.4 years at diagnosis. Abdominal pain, irregular periods, headache, and visual disturbances were reported at presentation by 100%, 71%, 57% and 43% of women, respectively. Three of seven women underwent ovarian surgery before FGA diagnosis. Six women underwent transsphenoidal surgery (TSS) with incomplete tumour resection in five of those, but all showed improvement or resolution in symptoms and biochemistry postoperatively.ConclusionFGA is a rare cause of spontaneous OHSS. TSS improves clinical and biochemical features of ovarian hyperstimulation in FGAs. Improved awareness of FGA will prevent inappropriate emergency ovarian surgery.
Assessing the potential of conspecific playbacks as a post‐translocation management tool for white rhinoceros
Authors: Pfannerstill Vera , Balkenhol Niko , Bennitt Emily , Maboga Onkgopotse Somalia , Scheumann Marina 
Published: July 2023

AbstractTranslocations can be a useful management tool to support endangered species. Translocated white rhinoceroses sometimes disperse from their release sites and leave protected areas, requiring sedation and return transport by vehicles. To avoid stressful transportation, less invasive management tools are needed to get animals back to the release site. We tested whether playbacks of white rhinoceros calls can influence their movements and thereby offer a potential management tool. We performed 200 experiments with 26 free‐roaming white rhinoceroses in two reserves in Botswana and recorded response intensity and duration, including body movement toward and away from the loudspeaker in response to a socio‐positive and a socio‐negative call. Rhinoceroses responded more to conspecific calls than to control sounds but did not show consistent behavioral responses across all experiments per call type. Males approached the loudspeaker more often than females. The intensity of responses was higher for calls recorded from unfamiliar than from familiar callers and behavioral responses differed between reserves. Further research is necessary to develop an applicable design for a combination of playbacks that would more reliably lead to directed body movement responses.
Derisking Developmentalism: A Tale of Green Hydrogen
Authors: Gabor Daniela , Sylla Ndongo Samba 
Published: July 2023

ABSTRACTIn the global race to scale up green hydrogen, a renewed appetite for the visible hand of the state once again promises to expand developmental space for low‐ and middle‐income countries. On the African continent, several countries have announced green industrialization ambitions that rely on mobilizing, through various ‘derisking’ schemes, private (institutional) capital looking for investible opportunities. To examine the transformative potential of this new derisking developmentalism, this article extends the critical macrofinance lens to include Thandika Mkandawire's theorization of post‐independence African developmental states. Using Namibia as an illustration, it argues that an assumption of ‘divine coincidence’ creates the ideological space for the state to forge derisking blocs but structurally weakens its ability to discipline private capital into pursuing green industrialization. As (foreign) capital dominates the state‒capital relationship in derisking developmentalism, the new green rules written by powerful investors and global North governments threaten to transform global South countries into consumers of green hydrogen technology and generators of yield for portfolio investors, thus reinforcing the structural drivers of their ongoing external debt vulnerabilities. Instead, countries should experiment with green public ownership and partnerships that discipline local green industries. Such strategies require replacing the Wall Street Consensus with a supportive global macrofinancial framework the authors call ‘Green Bandung Woods’.
Epidemiology of adult meningioma: Report from the Dutch Brain Tumour Registry (2000–2019)
Authors: Ho Vincent K. Y. , Anten Monique M. , Garst Anniek , Bos Eelke M. , Snijders Tom J. , Eekers Daniëlle B. P. , Seute Tatjana ,   the Dutch Brain Tumour Registry (DBTR) and the Dutch Society for Neuro‐Oncology (LWNO)
Published: July 2023

AbstractBackground and purposeMeningiomas are the most common primary tumours of the central nervous system. This study aimed to provide comprehensive nationwide estimates on the incidence, prevalence and prognostic impact of meningioma diagnosis in the Netherlands.MethodsAdult patients diagnosed with meningioma in 2000–2019 were selected from the Dutch Brain Tumour Registry (DBTR), part of the Netherlands Cancer Registry (NCR). Time trends in age‐adjusted incidence and prevalence rates were evaluated using the estimated annual percentage change (EAPC). Relative survival rates were calculated using the Pohar Perme estimator. Case completeness of the DBTR/NCR was estimated through record linkage with one of the Dutch neuro‐oncology centres.ResultsFrom a total of 23,454 cases of meningioma, 11,306 (48.2%) were histologically confirmed and 12,148 (51.8%) were radiological diagnoses. Over time, the incidence of diagnosis increased from 46.9 per 1,000,000 inhabitants (European Standardized Rate [ESR]) to 107.3 (EAPC 4.7%, p < 0.01), with an increase in the incidence of radiological diagnoses from 14.0 to 70.2 per 1,000,000 ESR (EAPC 9.1%, p < 0.01). The prevalence of meningioma was estimated at 1012/1,000,000 on 1 January 2020, with almost 17,800 individuals having had a diagnosis of meningioma. Relative survival rate at 10 years for grade 1 meningiomas was 91.0% (95% confidence interval [CI] 89.4%–92.3%), 71.3% (95% CI 66.8%–75.2%) for grade 2 meningiomas and 36.4% (95% CI 27.3%–45.6%) for grade 3 meningiomas. Local case completeness was estimated at 97.6% for histologically confirmed meningiomas and 84.5% for radiological diagnoses.ConclusionWith a near‐complete registry, meningioma prevalence was estimated at over 1000 per 1,000,000 inhabitants.
Warm oceans exacerbate Chinook salmon bycatch in the Pacific hake fishery driven by thermal and diel depth‐use behaviours
Authors: Sabal Megan C. , Richerson Kate , Moran Paul , Levi Taal , Tuttle Vanessa J. , Banks Michael 
Published: July 2023

AbstractFisheries bycatch impacts marine species globally and understanding the underlying ecological and behavioural mechanisms could improve bycatch mitigation and forecasts in novel conditions. Oceans are rapidly warming causing shifts in marine species distributions with unknown, but likely, bycatch consequences. We examined whether thermal and diel depth‐use behaviours influenced bycatch of a keystone species (Chinook salmon; Oncorhynchus tshawytscha, Salmonidae) in the largest fishery on the US West Coast (Pacific hake; Merluccius productus, Merlucciidae) with annual consequences in a warming ocean. We used Generalized Additive Models with 20 years of data including 54,509 hauls from the at‐sea hake fishery spanning Oregon and Washington coasts including genetic information for five salmon populations. Our results demonstrate that Chinook salmon bycatch rates increased in warm ocean years explained by salmon depth‐use behaviours. Chinook salmon typically occupy shallower water column depths compared to hake. However, salmon moved deeper when sea surface temperatures (SSTs) were warm and at night, which increased overlap with hake and exacerbated bycatch rates. We show that night fishing reductions (a voluntary bycatch mitigation strategy) are effective in reducing salmon bycatch in cool SSTs by limiting fishing effort when diel vertical movements bring salmon deeper but becomes less effective in warm SSTs as salmon seek deeper thermal refugia during the day. Thermal and diel behaviours were more pronounced in southern compared with northern salmon populations. We provide mechanistic support that climate change may intensify Chinook salmon bycatch in the hake fishery and demonstrate how an inferential approach can inform bycatch management in a changing world.
Deterministic approach on microstructurally small crack definition based on a crystalline plasticity finite element method incorporating strain localization
Authors: Li Wanjia , Hamada Shigeru 
Published: July 2023

AbstractThe transition point of the crack length to a microstructurally small crack is necessary for predicting crack extension behavior. The conventional criterion is the crack length smaller than the grain size and is a probabilistic criterion. This criterion does not consider the metal's crystallite plasticity property discrepancy (CPPD). However, CPPD determines crack extension behavior for recently developed advanced materials with complex microstructures. Therefore, the authors propose a deterministic judgment method for microstructurally small cracks considering crystallite plasticity based on a physics‐based crystal plasticity finite element model with strain localization. The proposed method is based on the difference value of the crack tip opening displacement varying with the ratio between the crack length and grain size with the change in the grain orientation ahead of the crack tip. A case study for copper is performed, and the results show that the novel method can be applied to define the microstructurally small crack.
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Authors: Song Yaoyao , Chen Zequn , Zhu Minhui , Chu Wanli , Liu Gang , Shen Chuan'an 
Published: July 2023

AbstractThe cover image is based on the Original Article The application of the Limberg flap repair technique in the surgical treatment of pilonidal sinus disease by Yaoyao Song et al., https://doi.org/10.1111/iwj.14105.
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Development and testing of a patient‐reported experience measure for cancer: A cross‐sectional survey
Authors: Reid Carol , Jones Lee , Janda Monica , Langbecker Danette , Stone Leanne , Laing Bobbi , McCarthy Alexandra 
Published: July 2023

AbstractAimTo develop and psychometrically test the Patient‐reported Experience Measure‐Cancer (PREM‐C), reflecting patients' perceptions of cancer care experiences according to the Institute of Medicine domains.DesignA three‐phase cross‐sectional survey was conducted.MethodsDevelopment, reliability and validity testing of the PREM‐C measure was undertaken. Data collection included three phases: firstly (development) between October and November, 2015; secondly (psychometric testing), May 2016–June, 2017, and finally, (revision and psychometric testing) May 2019–March 2020.ResultsThe final PREM‐C structure, created using the Institute of Medicine domains, was psychometrically sound with five factors identified in the Exploratory Factor Analysis, demonstrating internal reliability ranging from 0.8 to 0.9. Confirmatory Factor Analysis indicated the hypothesized model fitted well (Root mean square error of approximation = 0.076). External convergent and divergent validity was established with the PREM‐C found to be moderately correlated with the Picker Patient Experience Questionnaire but weakly correlated with the WHOQoL‐BREF.ConclusionThe development and testing of the PREM‐C demonstrated good fit as a clinically relevant measure of ambulatory cancer patients' experiences of care. To make meaningful changes to nursing practice and health services, patient experience measures such as the PREM‐C might support staff to identify areas for service improvement.ImpactFew reliable measures and less validated measures collect patients' perceptions of the quality of their healthcare provision. Rigorous psychometric testing of the newly developed PREM‐C demonstrated good internal consistency, test–retest reliability, and external convergent and divergent validity. The PREM‐C is a potentially relevant measure of cancer patients' experiences of care. It might be used to assess patient‐centred care and guide safety and quality improvements in clinical settings. PREM‐C use might inform service providers of experiences of care in their institution and inform policy and practice development. This measure is sufficiently generic, allowing potential use in other chronic disease populations.Patient or Public ContributionThis conduct of this study was supported by the participating patients of the hospital Cancer Outpatients Service.