bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
Authors: Niu Isabella , Hsiao Edward C. , Wustrack Rosanna , Wysolmerski John J. , Dann Pamela , Masharani Umesh 
Published: June 2023

AbstractThe treatment of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia of malignancy includes treating the malignancy, intravenous fluids, and anti-resorptive therapies such as zoledronic acid or denosumab. PTHrP-mediated hypercalcemia has been reported in benign conditions such as systemic lupus erythematous (SLE) and sarcoidosis and appears to be responsive to glucocorticoids. We report a case of PTHrP-induced hypercalcemia due to a malignancy—low grade fibromyxoid sarcoma—that responded to glucocorticoid treatment. This is the first report of glucocorticoids controlling PTHrP-mediated hypercalcemia of malignancy. Immunohistochemistry of the surgical pathology localized PTHrP staining to the vascular endothelial cells within the tumor. Further studies are needed to elucidate the mechanism of glucocorticoid action in the treatment of PTHrP-mediated hypercalcemia of malignancy.
Intraductal oncocytic papillary neoplasm of the pancreas: clinical and radiological features compared to those of intraductal papillary mucinous neoplasm
Authors: Nakaya Moto , Nakai Yudai , Takahashi Mai , Fukukura Yoshihiko , Sato Keisuke , Kameda Arisa , Tashiro Yuki , Kageyama Sakiko , Sofue Keitaro , Nakano Tsubasa , Yoshimitsu Kengo , Marugami Nagaaki , Takeyama Nobuyuki , Tanaka Mariko , Hasegawa Kiyoshi , Watadani Takeyuki 
Published: June 2023

Abstract
Purpose
This study aimed to characterize the clinical and imaging findings of intraductal oncocytic papillary neoplasm of the pancreas (IOPN-P) compared to those of intraductal papillary mucinous adenoma/carcinoma (IPMA/IPMC).

Methods
This multi-institutional retrospective study reviewed the clinical, imaging, and pathological findings of 21 patients with pathologically proven IOPN-P. Twenty-one computed tomography (CT) and magnetic resonance imaging, and seven 18F-fluorodeoxyglucose (FDG)-positron emission tomography were performed before surgery. The following findings were evaluated: preoperative blood test results, lesion size and location, pancreatic duct diameter, contrast-enhancement effect, bile duct and peripancreatic invasion, maximum standardized uptake (SUVmax) value, and pathological stromal invasion.

Results
Serum carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9) levels were significantly higher in the IPMN/IPMC group than in the IOPN-P group. Except in one patient, IOPN-P showed multifocal cystic lesions with solid components or a tumor in the main pancreatic duct (MPD) with dilatation. IOPN-P had a higher frequency of solid parts and a lower frequency of downstream MPD dilatation than IPMA. IPMC showed smaller overall cyst size, more radiological peripancreatic invasion, and worse recurrence-free and overall survival than IOPN-P. The average SUVmax value of IOPN-P was 7.5. Pathologically, 17 of the 21 IOPN-Ps had a malignant component, and six showed stromal invasion.

Conclusion
IOPN-P shows cystic-solid lesions similar to IPMC but has lower serum CEA and CA19-9 levels, larger overall cyst size, lower frequency of peripancreatic invasion, and more favorable prognosis than IPMC. Moreover, the high FDG uptake by IOPN-Ps may be a characteristic finding of this study.

Graphical abstract
„Mild-behavioral-impairment“-Checkliste
Authors: Dibbern Pauline , Horsch Jennifer , Fiegl Julia , Eckl Linda , Finger Tamara , Diermeier Lisa , Deppe Markus , Schiekofer Stephan , Langguth Berthold , Ismail Zahinoor , Barinka Filip 
Published: June 2023

Zusammenfassung
Hintergrund
Das Syndrom einer leichten Verhaltensbeeinträchtigung („mild behavioral impairment syndrome“, MBI) ist definiert durch das Auftreten anhaltender neuropsychiatrischer Symptome im Alter. Die Mild-behavioral-impairment-Checkliste (MBI-C) dient der Erfassung von persistierenden neuropsychiatrischen Symptomen, welche die Präsenz des MBI definieren.

Ziel
Erarbeitung einer deutschsprachigen Version der MBI‑C und Beurteilung der klinischen Anwendbarkeit.

Material und Methoden
Im Austausch mit dem federführenden Autor der englischen Originalversion wurde eine deutsche Version erstellt. Die Praktikabilität der Anwendung wurde im Rahmen einer Anwendbarkeitsstudie an einer Kohorte von 21 stationären alterspsychiatrischen Patienten überprüft. Dabei wurden die Compliance der Patienten, die Verständlichkeit, der Zeitaufwand, das Vorgehen bei der Auswertung und die Unterschiede zwischen den Angaben der Patienten und der Angehörigen beurteilt.

Ergebnisse
Die erstellte Übersetzung der MBI‑C gilt als offizielle deutsche Version und kann auf https://mbitest.org heruntergeladen werden. Alle Patienten beantworteten alle 34 Fragen vollständig, die Verständlichkeit zeigte sich als sehr gut, der durchschnittliche Zeitaufwand lag bei 16 min. Es zeigten sich z. T. bedeutsame Unterschiede zwischen den Angaben der Patienten und der Angehörigen.

Diskussion
Das MBI kann bei einem Teil der Personen mit neurodegenerativer demenzieller Erkrankung das ansonsten präsymptomatische Stadium markieren. Die MBI‑C könnte somit bei der Früherkennung von neurodegenerativen Demenzen helfen. Diese Hypothese kann mithilfe der hier präsentierten sprachlich lokalisierten Version der MBI‑C auch im deutschsprachigen Raum zukünftig überprüft werden.
Austrian consensus on the diagnosis and management of portal hypertension in advanced chronic liver disease (Billroth IV)
Authors: Mandorfer Mattias , Aigner Elmar , Cejna Manfred , Ferlitsch Arnulf , Datz Christian , Gräter Tilmann , Graziadei Ivo , Gschwantler Michael , Hametner-Schreil Stephanie , Hofer Harald , Jachs Mathias , Loizides Alexander , Maieron Andreas , Peck-Radosavljevic Markus , Rainer Florian , Scheiner Bernhard , Semmler Georg , Reider Lukas , Reiter Silvia , Schoder Maria , Schöfl Rainer , Schwabl Philipp , Stadlbauer Vanessa , Stauber Rudolf , Tatscher Elisabeth , Trauner Michael , Ziachehabi Alexander , Zoller Heinz , Fickert Peter , Reiberger Thomas 
Published: June 2023

SummaryThe Billroth IV consensus was developed during a consensus meeting of the Austrian Society of Gastroenterology and Hepatology (ÖGGH) and the Austrian Society of Interventional Radiology (ÖGIR) held on the 26th of November 2022 in Vienna.Based on international recommendations and considering recent landmark studies, the Billroth IV consensus provides guidance regarding the diagnosis and management of portal hypertension in advanced chronic liver disease.
Agriculture and environment: friends or foes? Conceptualising agri-environmental discourses under the European Union’s Common Agricultural Policy
Authors: Rac Ilona , Erjavec Karmen , Erjavec Emil 
Published: June 2023

AbstractThe European Union’s common agricultural policy (CAP), in addition to its primary production and farm income goals, is a large source of funding for environmentally friendly agricultural practices. However, its schemes have variable success and uptake across member states (MS) and regions. This study tries to explain these differences by demonstrating differences between policy levels in the understanding of the relationship between nature and farming. To compare constructs and values of the respective policy communities, their discursive construction as it appears in the main strategic EU and MS agricultural policy documents is analysed. The theoretical framework integrates elements from existing frameworks of CAP and environmental discourse analysis; specific agri-environmental discourses, their elements and interplay, are identified. The six discourses suggested here are ‘Productivism’, ‘Classical neoliberal’, ‘Ecological modernisation’, ‘Administrative’, ‘Multifunctionality’ and ‘Radical green’. The discourse analysis of selected documents reveals that there are indeed differences in how farming and the environment are generally conceptualised at different levels of CAP decision-making. At EU level, farming is primarily understood as a sector whose main task is to produce food (‘Productivism’), and the environment is used as a justification for CAP payments (‘Multifunctionality’). At the national/regional level, Rural Development Programmes reflect different value systems: in England, environmental protection is mainly seen as sound management of natural capital (‘Classical neoliberal’); in Finland, a benefit for producers and conscious consumers (‘Ecological modernisation’); in Croatia, a necessity limiting productivity (‘Productivism’) and imposed by an external authority (‘Administrative’ discourse). This diversity shows that differences can visibly manifest despite the Commission constraining the discursive space, helping to explain the differential implementation and success of environmental measures.
Evaluation of the danger of a tailings pile belonging to an active mine through its characterization and a dispersion model
Authors: González-Sánchez Jesús Fidel , Mendoza-Lara Osiel O. , Romero-Hernández Jorge Luis , Fernández-Villagómez Georgina 
Published: June 2023

AbstractMining is one of the principal economic activities in Mexico, which in addition to bringing benefits to the population, causes health and environmental problems. This activity produces a lot of wastes, but the main one is tailings. In Mexico, these wastes are disposed of in the open air, and there is no control over them, so the particles of these wastes are dispersed by wind currents to the surrounding population. In this research, tailings were characterized, finding in them particles smaller than 100 microns; in this way, tailings can enter into the respiratory system and hence can cause diseases. Furthermore, it is important to identify the toxic components. The present work does not have previous research in Mexico, and it shows a qualitative characterization of the tailings from an active mine using different analytical techniques. In addition to the data obtained from the characterization of the tailings, as well as the concentration of the toxic elements found, which were Pb and As, a dispersal model was generated and used to estimate the concentration of particles in the wind generated at the studied area. The air quality model used in this research is AERMOD, where it uses emission factors and available databases provided by Environmental Protection Agency (USEPA); Moreover, the model was coupled with meteorological information from the latest generation WRF model. The modeling results estimated that the dispersion of particles from the tailings dam can contribute up to 10.15 µg/m3 of PM10 to the air quality of the site, which, according to the characterization of the samples obtained, could be dangerous for human health and can be estimated up to a concentration of 0.04 µg/m3 of Pb and 10.90 ng/m3 of As. It is very important to make this kind of research to know the risk which people around this disposal sites are exposed to.
“You give a little bit more love to animals than to robots”: primary pupils’ conceptions of ‘programming’ and programmable artefacts
Authors: Axell Cecilia , Berg Astrid 
Published: June 2023

AbstractAlthough digital technology is an important part of young people’s lives, previous research implies that they have a limited understanding of what programming is and its connection to the digital devices they encounter every day. In order to create conditions for meaningful teaching in and about programming in technology education, more knowledge about younger students’ pre-understanding and experiences is needed. In the light of this, the aim of this case study was to explore young pupils’ descriptions of the concept ‘programming’, in connection with being introduced to programming as a teaching content in technology education. The study is based on semi-structured interviews with 16 children in year 1 (7-year-olds) in a primary school in Sweden. In their descriptions of ‘programming’ as an activity, the pupils mainly used technological descriptions—a theory of artificial mind perspective. However, when they talked about the objects with which they associated programming, psychological descriptions—a theory of mind perspective—were more clearly present. Then, a less pronounced distinction between humans and machines was made. Anthropomorphic references were used, such as when the pupils referenced children’s culture such as movies and television programs. However, the term ‘programming’ was difficult for many of the pupils to grasp. They also had difficulty in finding a function for programming, as well as explanations and arguments for why they learn programming in school. The results of this study indicate that these 7-year-old pupils perceive ‘programming’ as something complex. This at the same time as they describe how programmed and programmed artefacts (including AI devices) are highly present in their everyday lives, in their leisure environments, and in school. This mirrors how technology has become an ‘intelligent’ and active agent, rather than a mere tool in their lives—an aspect that teachers may forget to take advantage of.
Immunoglobulin Replacement Therapy During COVID-19 Pandemic: Practical and Psychological Impact in Patients with Antibody Deficiency
Authors: Maimaris Jesmeen , O’Sullivan Anjel , Underhill Isabella , Green Ghiselle , Symes Andrew , Lowe David , Burns Siobhan , Campbell Mari , Elfeky Reem 
Published: June 2023

AbstractPurposeThe COVID-19 pandemic has impacted on how health services deliver care and the mental health of the population. Due to their clinical vulnerability, to reduce in-hospital attendances during the COVID-19 pandemic, modifications in immunoglobulin treatment regimens were made for patients with antibody deficiency. These patients were also likely to experience social isolation due to shielding measure that were advised. We aimed to investigate the impact of modifying immunoglobulin treatment regimen on infection and mental health burden during shielding restrictions.MethodPatients on immunoglobulin replacement therapy (IGRT) responded to a standardised questionnaire examining self-reported infection frequency, anxiety (GAD-7), depression (PHQ-8), fatigue (FACIT), and quality of life during the pandemic. Infection frequency and immunoglobulin trough levels were compared to pre-pandemic levels.ResultsPatients who did not change treatment modality or those who received immunoglobulin replacement at home during the pandemic reported fewer infections. In patients who received less frequent hospital infusions, there was no significant increase in infections whilst immunoglobulin trough levels remained stable. There was no significant difference in anxiety, or depression scores between the treatment modality groups. Patients reported higher fatigue scores compared to the pre-COVID general population and in those discharged following hospitalisation for COVID.ConclusionChanging immunoglobulin treatment regimen did not negatively impact infection rates or psychological wellbeing. However, psychological welfare should be prioritised for this group particularly given uncertainties around COVID-19 vaccination responsiveness and continued social isolation for many.
Degradation of Crystal Violet Using Gadolinium Zirconium Oxide (Gd2Zr2O7) Nanoparticles
Authors: Abdelbaky M. , Abdelghany A. M. , Oraby A. H. , Abdelrazek E. M. , Rashad M. M. 
Published: June 2023

Abstract
The demand for clean water free of pollution has become an urgent priority for humanity. Gd2Zr2O7 nanoparticles were successfully synthesized via sol–gel auto combustion as a type of pyrochlore to be used in the dye phytoremediation using a Fenton-like approach. Gd2Zr2O7 nanoparticles have been successfully prepared using a sol–gel auto-combustion strategy. The annealing process was performed in a furnace at 1100 °C for 2 h to form defect-fluorite structured Gd2Zr2O7 with space group Fm-3m. XRD analysis revealed that synthesized Gd2Zr2O7 nanoparticles were found to have crystallite sizes with lattice parameters of 28.5 nm and 10.524 + 0.02 Å, respectively. TEM micrographs showed the presence of a cubic-like structure with a size of about 17 nm. The band gap energy of the synthesized powders was found to be 3.8 eV relating to the impact of the crystallite size. The generated nanoparticles finally show a significant photo Fenton catalytic activity with an efficiency of 90% for the photocatalysis of crystal violet dye after 60 min. It was determined that the substantial absorption of Gd2Zr2O7 in the visible-light region, which was synergistically activated by both Gd3+ and Zr4+ ions, was the cause of the large surface area of the scattered microstructure and reactive OH. formation.
metaFERA: a meta-framework for creating emotion recognition frameworks for physiological signals
Authors: Oliveira João , Alarcão Soraia M. , Chambel Teresa , Fonseca Manuel J. 
Published: June 2023

AbstractRecognizing emotions from physiological signals has proven to be important in various scenarios. To assist in developing emotion recognizers, software frameworks and toolboxes have emerged, offering ready-to-use components. However,these have limitations regarding the type of physiological signals supported, the recognition steps covered, or the acquisition of multiple physiological signals. This paper presents metaFERA, an architectural meta-framework for creating software frameworks for end-to-end emotion recognition from physiological signals. The modularity and flexibility of the meta-framework and the resulting frameworks allow the fast prototyping of emotion recognition systems and experiments to test and validate new algorithms. To that end, metaFERA offers: (i) a set of pre-configured blocks to which we can add behavior to create framework components; (ii) an easy way to add behavior to the pre-configured blocks; (iii) a channel-based communication mechanism that transparently and efficiently supports the exchange of information between components; (iv) a simple and easy way to use and link components from a resulting framework to create applications. Additionally, we provide a set of Web services, already configured, to make the resulting recognition systems available as a service. To validate metaFERA, we created a framework for Electrodermal Activity, an emotion recognizer to identify high/low arousal using the aforementioned framework, and a layer to offer the recognizer as a service.
Current advances in alteration of fatty acid profile in Rhodotorula toruloides: a mini-review
Authors: Wu Chih-Chan , Honda Kohsuke , Kazuhito Fujiyama 
Published: June 2023

AbstractMicrobial lipids are considered promising and environmentally friendly substitutes for fossil fuels and plant-derived oils. They alleviate the depletion of limited petroleum storage and the decrement of arable lands resulting from the greenhouse effect. Microbial lipids derived from oleaginous yeasts provide fatty acid profiles similar to plant-derived oils, which are considered as sustainable and alternative feedstocks for use in the biofuel, cosmetics, and food industries. Rhodotorula toruloides is an intriguing oleaginous yeast strain that can accumulate more than 70% of its dry biomass as lipid content. It can utilize a wide range of substrates, including low-cost sugars and industrial waste. It is also robust against various industrial inhibitors. However, precise control of the fatty acid profile of the lipids produced by R. toruloides is essential for broadening its biotechnological applications. This mini-review describes recent progress in identifying fatty synthesis pathways and consolidated strategies used for specific fatty acid-rich lipid production via metabolic engineering, strain domestication. In addition, this mini-review summarized the effects of culture conditions on fatty acid profiles in R. toruloides. The perspectives and constraints of harnessing R. toruloides for tailored lipid production are also discussed in this mini-review.
Graphical abstract
Recent Immigrants’ Religious Change in a Secular Context and its Relation with Social Integration
Authors: Fleischmann Fenella , Khoudja Yassine 
Published: June 2023

AbstractThis paper examines how integration into various sub-domains of the receiving society, including the labor market, informal contacts, attitudes and values, and identification, is associated with religious change among recent Christian and Muslim immigrants in the Netherlands—one of the least religious countries in Europe. The analysis uses data from the New Immigrants to the Netherlands Survey (NIS2NL), a four-wave panel study of recently arrived immigrants from four countries (Bulgaria, Poland, Spain and Turkey). Using latent growth models, we identify the average trajectory of religious participation (service attendance and prayer) and identity (subjective importance of religion) of recent immigrants and examine the role of time-invariant and time-varying explanations for religious change in the early years of resettlement. We find that immigrants’ religious practices increase in the first years after arrival, following a substantial drop from pre-migration participation levels. However, this increase eventually levels off and even reverses with increasing length of stay. We observe a linear but modest decrease in religious identification over time that replicates across all origin groups. In line with expectations derived from assimilation theory, we find that migrants who are employed and hold more liberal attitudes regarding homosexuality, gender relations, divorce and abortion show a greater decrease in religiosity, whereas the opposite is true for those who identify more strongly with their origin country. The findings are remarkably similar for Muslim and Christian newcomers and suggest that all immigrants are susceptible to the secularizing forces of the receiving society. This indicates the potential for the “bright” boundary between Muslim immigrants and secular hosts to become more “blurred” with increasing length of stay and integration into “the mainstream”.
The effect of lockup and persuasion on online investment decisions: An experimental study in ICOs
Authors: Bruckner Moritz T. , Steininger Dennis M. , Thatcher Jason Bennett , Veit Daniel J. 
Published: June 2023

AbstractMany firms use social media (SM) to solicit online investments. In this study, we examine the interaction between SM attributes and online-investment attributes to determine how this interaction shapes users’ investment decisions. Specifically, we investigate initial coin offerings (ICOs) as an application domain of distributed ledger technology for peer-to-peer investment. We use signaling theory to develop a context-specific explanation for how the interplay of persuasion signals found in SM and technology-enforced lockups shapes individuals’ ICO investment decisions. To evaluate this interplay, we conducted a 2 × 2 factorial experiment with 473 participants. The results show that when an investment does not require a technology-enforced lockup, persuasion signals encourage investments in ICOs; however, when an investment requires a technology-enforced lockup, persuasion signals do not affect investments in ICOs. Furthermore, our analyses suggest that combining a technology-enforced lockup and persuasion signals reduces the ICO’s plausibility. This is the first study to investigate how the willingness to invest in ICOs is influenced by the relationship between technology-enforced lockups and persuasion signals. The findings have practical implications for individuals attempting to make sound decisions on ICO investments, policymakers regulating online investments, and firms seeking to attract investors.