bluuebunny/crossref_metadata_2025_split huggingface dataset:
Half-Power Prediction and Its Application on the Energy Management Strategy for Fuel Cell City Bus
Authors: Zhang Longhai , Ning Lina , Yang Xueqing , Zeng Sheng , Yuan Tian , Li Gaopeng , Ke Changchun , Zhang Junliang 
Published: February 2023

AbstractThe fuel cell hybrid powertrain is a potential power supply system for fuel cell vehicles. The underlying problem is that the fuel cell vehicles encounter exhaustive hydrogen consumption. To effectively manage hydrogen consumption, the aim is to propose fuel cell city bus power and control system. The underlying idea is to determine the target power of fuel cell through simulation study on fuel cell and battery energy management strategy and road test verifications. A half-power prediction energy management strategy is implemented to predict the target power of the fuel cell in the current time step based on the demand power of the vehicle and the state of charge (SOC) of the battery in the previous time steps. This offers better understanding of the correlation between fuel cell power and vehicle drive cycle for enabling effective power supply management. The research results show that the half-power prediction energy management strategy effectively reduces the hydrogen consumption of the vehicle by 7.1% and the number of battery cycle by 6.0%, compared to the stepped management strategy of battery SOC. When applied to a 12-m fuel cell city bus—F12, specially designed and manufactured for the Winter Olympic Games in 2022—the fuel economy of 3.7 kg/100 km is achieved in urban road conditions. This study lays a foundation for providing the powertrain configuration and energy management strategy of fuel cell city bus.
Netherton Syndrome, a Rare Genetic Disorder—Case Report
Authors: Almalki Yahya , Khan Faisal , Naeem Ammara , Alabdulghany Muhammad Hasan 
Published: February 2023

AbstractNetherton syndrome is a rare genetic disorder inherited in an autosomal recessive pattern. Mutations in the serine protease inhibitor Kazal-type 5 (SPINK5) gene are responsible for this disorder. Netherton syndrome can have multisystemic effects primarily involving the hair, skin and immune system. Currently, no definitive treatment has been reported beyond supportive care. Herein, we report the case of a newborn delivered in our facility with erythematous skin with peeling rash, respiratory distress and suspected early onset sepsis. In the neonatal intensive care unit, the newborn was managed with continuous positive airway pressure support, initial antibiotics and supportive treatment. Diagnosis was established after a skin biopsy, hair sample showing a characteristic bamboo stick appearance and elevated immunoglobulin E levels.
Preventing monkeypox outbreaks: Focus on diagnosis, care, treatment, and vaccination
Authors: Ghaseminia Moslem 
Published: February 2023

AbstractThe first human case of monkeypox virus (Mpox) was reported in 1970. In the years after 1970, human infection with Mpox and human-to-human transmission was not widely observed, and more cases were seen in endemic areas. In that year, Mpox spread was confirmed through the export of infected animals to other parts of the world. Every few years, sporadic infections were reported in different parts of the world from human contamination and human-to-human transmission. In recent years, with the slow decline of the COVID-19 pandemic, the outbreak of Mpox was observed in many countries of the world. To deal with the spread of this viral infection, we need to know the ways to diagnose the infection, treat the infection, care for the patients, and implement a wide program of vaccination. Currently, there are no specific drugs available for this virus, but according to previous studies related to smallpox, drugs such as tecovirimat, cidofovir, and brincidofovir, which were used for smallpox and other orthopoxviruses in the past, can be considered to deal with Mpox. Also, some vaccines such as JYNNEOS, IMVAMUNE, and MoVIHvax that have been used against smallpox can be useful to some extent in preventing Mpox.
Acoustofluidic semen analysis for veterinary male bovine infertility assessment
Authors: Castro Jasmine O. , Abdul Halim Melati S. , Ambattu Lizebona A. , Rezk Amgad R. , Prabhakar Ranganathan , Nosrati Reza , Yeo Leslie Y. 
Published: February 2023

We demonstrate through the use of a unique acoustically driven microfluidic extensional rheometry platform (ADMiER) that a single measurement – i.e. the time required for a liquid bridge filament comprising a microlitre semen sample to thin and break up under elastocapillary stresses – constitutes an appropriate proxy for quantifying the motile sperm concentration of the sample in place of computer-assisted sperm analysis (CASA) and haemocytometer measurements used in conventional semen assessment – without the need to separately resolve for individual dependencies on each sperm parameter. By benchmarking diagnostic test accuracy results of blind random bull semen samples (

$n=35$

) against OpenCASA measurements of these parameters, ADMiER is capable of predicting sperm quality to 93.7 % accuracy, 91.4 % sensitivity and 97.5 % specificity, with respect to commonly adopted veterinary industry minimum values for fertility. These results therefore highlight the potential diagnostic capability of the platform as a conceptual first step towards the development of a rapid, low-cost and portable alternative for veterinary male bovine fertility assessment.
Guided parent-delivered cognitive behavioural therapy for Japanese children and parents: a single-arm uncontrolled study
Authors: Okawa Sho , Arai Honami , Nakamura Hideki , Ishikawa Shin-ichi , Creswell Cathy , Shiko Yuki , Ozawa Yoshihito , Kawasaki Yohei , Shimizu Eiji 
Published: February 2023

AbstractBackground:Guided parent-delivered cognitive behavioural therapy (GPD-CBT) is an effective low-intensity treatment for childhood anxiety disorder in Western countries and can increase access to evidence-based psychological therapies.Aim:This study aimed to examine its feasibility in a Japanese sample.Method:Twelve children with anxiety disorders and their parents participated in the study, and ten children and parents completed the program. Participants were assessed at pre-, post- and one-month follow-up using a diagnostic interview for anxiety disorders, self- and parent-report measures for anxiety, depression, parental behaviour, and parental anxiety.Results:Four children (40% of completers) were free from their primary diagnoses immediately following the brief treatment, and seven children (70%) at the one-month follow-up. Changes in disorder severity, child and parent reported anxiety symptoms, and child reported depression symptoms were consistent with those found in Western trials of GPD-CBT and of Japanese trials of more intensive CBT for child anxiety disorders that involves both the child and the parent. Moderate increases were also found in child reported parental autonomy behaviours; however, there were only small changes in parent self-reported anxiety.Conclusion:These results support the potential of GPD-CBT to increase access to evidence-based treatments for anxiety disorders in Japanese children.
Space and the US–Japan alliance: reflections on Japan's geopolitical and geoeconomic strategy
Authors: Pekkanen Saadia M. 
Published: February 2023

AbstractJapan, and its alliance with the USA, is central to the unfolding politics of the new space race. This essay draws attention to the ways the Japanese state has positioned its geopolitical and geoeconomic interests related to space in the context of the US–Japan alliance. It probes the material and ideational elements that are driving the Japanese state to closer alignment with its formal ally in the military, civilian, and commercial space domains. But while all these realities bode well for alliance collaboration, there are reasons to be cautious. While the Japanese state has proactively aligned its space policy and postures with the USA, it is not forever caught in the US orbit. Given the uncertain fate of US domestic politics that bears on great power competition, Japan is also prudently positioning for how the status of its ally may evolve. This is what complicates straightforward projections about alliance cooperation and balance of power politics in the unfolding international space order.
Detection of Deep Low‐Frequency Tremors From Continuous Paper Records at a Station in Southwest Japan About 50 Years Ago Based on Convolutional Neural Network
Authors: Kaneko Ryosuke , Nagao Hiromichi , Ito Shin‐ichi , Tsuruoka Hiroshi , Obara Kazushige 
Published: February 2023

AbstractSince deep low‐frequency tremors are considered to be associated with large earthquakes that occur adjacently on the same subducting plate interface, it is important to investigate tremors that occurred before the establishment of modern seismograph networks such as the High Sensitivity Seismograph Network (Hi‐net). We propose a deep‐learning solution to detect evidence of tremors in scanned images of paper seismogram records from over 50 years ago. In this study, we fine‐tuned a convolutional neural network (CNN) based on the Residual Network, which was pre‐trained using images of synthetic waveforms from our previous study, using a data set comprised of images generated from real seismic data recorded digitally by Hi‐net to facilitate a supervised analysis. The fine‐tuned CNN was able to predict the presence or absence of tremors in the Hi‐net images with an accuracy of 98.64%. Gradient‐weighted Class Activation Mapping heatmaps created to visualize model predictions indicated that the CNN's ability to detect tremors is not degraded by the presence of teleseisms. Once validated using the Hi‐net images, the CNN was applied to paper seismograms recorded from 1966 to 1977 at the Kumano observatory in southwest Japan, operated by Earthquake Research Institute, The University of Tokyo. The CNN showed potential for detecting tremors in scanned images of paper seismogram records from the past, facilitating downstream tasks such as the creation of new tremor catalogs. However, further training using an augmented data set to control for variables such as inconsistent plotting pen thickness is required to develop a universally applicable model.
The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases
Authors: Kim Dong-Hyun , Park Jung Sun , Choi Hoon-In , Kim Chang Seong , Bae Eun Hui , Ma Seong Kwon , Kim Soo Wan 
Published: February 2023

AbstractThe prevalence of kidney diseases has been increasing worldwide due to the aging population and has results in an increased socioeconomic burden as well as increased morbidity and mortality. A deep understanding of the mechanisms underlying the physiological regulation of the kidney and the pathogenesis of related diseases can help identify potential therapeutic targets. The farnesoid X receptor (FXR, NR1H4) is a primary nuclear bile acid receptor that transcriptionally regulates bile acid homeostasis as well as glucose and lipid metabolism in multiple tissues. The roles of FXR in tissues other than hepatic and intestinal tissues are poorly understood. In studies over the past decade, FXR has been demonstrated to have a protective effect against kidney diseases through its anti-inflammatory and antifibrotic effects; it also plays roles in glucose and lipid metabolism in the kidney. In this review, we discuss the physiological role of FXR in the kidney and its pathophysiological roles in various kidney diseases, including acute kidney injury and chronic kidney diseases, diabetic nephropathy, and kidney fibrosis. Therefore, the regulatory mechanisms involving nuclear receptors, such as FXR, in the physiology and pathophysiology of the kidney and the development of agonists and antagonists for modulating FXR expression and activation should be elucidated to identify therapeutic targets for the treatment of kidney diseases.
CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility
Authors: Awad Patricia Nora , Zerbi Valerio , Johnson-Venkatesh Erin M. , Damiani Francesca , Pagani Marco , Markicevic Marija , Nickles Sarah , Gozzi Alessandro , Umemori Hisashi , Fagiolini Michela 
Published: February 2023

AbstractFunctional and structural connectivity alterations in short- and long-range projections have been reported across neurodevelopmental disorders (NDD). Interhemispheric callosal projection neurons (CPN) represent one of the major long-range projections in the brain, which are particularly important for higher-order cognitive function and flexibility. However, whether a causal relationship exists between interhemispheric connectivity alterations and cognitive deficits in NDD remains elusive. Here, we focused on CDKL5 Deficiency Disorder (CDD), a severe neurodevelopmental disorder caused by mutations in the X-linked Cyclin-dependent kinase-like 5 (CDKL5) gene. We found an increase in homotopic interhemispheric connectivity and functional hyperconnectivity across higher cognitive areas in adult male and female CDKL5-deficient mice by resting-state functional MRI (rs-fMRI) analysis. This was accompanied by an increase in the number of callosal synaptic inputs but decrease in local synaptic connectivity in the cingulate cortex of juvenile CDKL5-deficient mice, suggesting an impairment in excitatory synapse development and a differential role of CDKL5 across excitatory neuron subtypes. These deficits were associated with significant cognitive impairments in CDKL5 KO mice. Selective deletion of CDKL5 in the largest subtype of CPN likewise resulted in an increase of functional callosal inputs, without however significantly altering intracortical cingulate networks. Notably, such callosal-specific changes were sufficient to cause cognitive deficits. Finally, when CDKL5 was selectively re-expressed only in this CPN subtype, in otherwise CDKL5-deficient mice, it was sufficient to prevent the cognitive impairments of CDKL5 mutants. Together, these results reveal a novel role of CDKL5 by demonstrating that it is both necessary and sufficient for proper CPN connectivity and cognitive function and flexibility, and further validates a causal relationship between CPN dysfunction and cognitive impairment in a model of NDD.
Plasma proteins related to inflammatory diet predict future cognitive impairment
Authors: Duggan Michael R. , Butler Lauren , Peng Zhongsheng , Daya Gulzar N. , Moghekar Abhay , An Yang , Rapp Stephen R. , Hayden Kathleen M. , Shadyab Aladdin H. , Natale Ginny , Liu Longjian , Snetselaar Linda , Moaddel Ruin , Rebholz Casey M. , Sullivan Kevin , Ballantyne Christie M. , Resnick Susan M. , Ferrucci Luigi , Walker Keenan A. 
Published: February 2023

AbstractDysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women’s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer’s disease (AD) pathology (Aβ42/40) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment.
The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation
Authors: Li Zhaolong , Hao Pengfei , Zhao Zhilei , Gao Wenying , Huan Chen , Li Letian , Chen Xiang , Wang Hong , Jin Ningyi , Luo Zhao-Qing , Li Chang , Zhang Wenyan 
Published: February 2023

AbstractThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; its structural protein envelope (E) is critical for viral entry, budding, production, and induction of pathology which makes it a potential target for therapeutics against COVID-19. Here, we find that the E3 ligase RNF5 interacts with and catalyzes ubiquitination of E on the 63rd lysine, leading to its degradation by the ubiquitin-proteasome system (UPS). Importantly, RNF5-induced degradation of E inhibits SARS-CoV-2 replication and the RNF5 pharmacological activator Analog-1 alleviates disease development in a mouse infection model. We also found that RNF5 is distinctively expressed in different age groups and in patients displaying different disease severity, which may be exploited as a prognostic marker for COVID-19. Furthermore, RNF5 recognized the E protein from various SARS-CoV-2 strains and SARS-CoV, suggesting that targeting RNF5 is a broad-spectrum antiviral strategy. Our findings provide novel insights into the role of UPS in antagonizing SARS-CoV-2 replication, which opens new avenues for therapeutic intervention to combat the COVID-19 pandemic.
Resetting histone modifications during human prenatal germline development
Authors: Gao Rui , Zeng Shiyang , Yang Dongxu , Li Xiaocui , Liu Wenqiang , Gao Yawei , Bai Dandan , Zhang Linfeng , Chen Chuan , Kang Yunzhe , Wang Beiying , Hong Wei , Wang Mingzhu , Yin Jiqing , Wang Hong , Deng Qiaolin , Gao Shaorong , Zhang Yong , Chen Jiayu 
Published: February 2023

AbstractHistone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how they are reprogrammed during human prenatal germline development has not yet been elucidated. Here, we map the genome-wide profiles of three key histone modifications in human primordial germ cells (hPGCs) from weeks 8 to 23 of gestation for the first time by performing ULI-NChIP-seq. Notably, H3K4me3 exhibits a canonical promoter-enriched pattern, though with relatively lower enrichment, and is positively correlated with gene expression in globally hypomethylated hPGCs. In addition, H3K27me3 presents very low enrichment but plays an important role in not only dynamically governing specific bivalent promoters but also impeding complete X chromosome reactivation in female hPGCs. Given the activation effects of both global DNA demethylation and H3K4me3 signals, repressive H3K9me3 and H3K27me3 marks are jointly responsible for the paradoxical regulation of demethylation-resistant regions in hPGCs. Collectively, our results provide a unique roadmap of three core histone modifications during hPGC development, which helps to elucidate the architecture of germ cell reprogramming in an extremely hypomethylated DNA environment.
Spectroscopic evidence for the superconductivity of elemental metal Y under pressure
Authors: Cao Zi-Yu , Jang Harim , Choi Seokmin , Kim Jihyun , Kim Suyoung , Zhang Jian-Bo , Sharbirin Anir S. , Kim Jeongyong , Park Tuson 
Published: February 2023

AbstractVery high applied pressure induces superconductivity with the transition temperature (Tc) exceeding 19 K in elemental yttrium, but relatively little is known about the nature of that superconductivity. From point-contact spectroscopy (PCS) measurements in a diamond anvil cell (DAC), a strong enhancement in the differential conductance is revealed near the zero-biased voltage owing to Andreev reflection, a hallmark of the superconducting (SC) phase. Analysis of the PCS spectra based on the extended Blonder-Tinkham-Klapwijk (BTK) model indicates two SC gaps at 48.6 GPa, where the large gap ΔL is 3.63 meV and the small gap ΔS is 0.46 meV. When scaled against a reduced temperature, both small and large SC gaps collapse on a single curve that follows the prediction from BCS theory. The SC gap-to-Tc ratio is 8.2 for the larger gap, and the initial slope of the upper critical field is −1.9 T/K, indicating that Y belongs to a family of strongly coupled BCS superconductors. The successful application of PCS to Y in DAC environments demonstrates its utility for future research on other pressure-induced high-Tc superconductors.
Cation controlled rotation in anionic pillar[5]arenes and its application for fluorescence switch
Authors: Zheng Hao , Fu Lulu , Wang Ranran , Jiao Jianmin , Song Yingying , Shi Conghao , Chen Yuan , Jiang Juli , Lin Chen , Ma Jing , Wang Leyong 
Published: February 2023

AbstractControlling molecular motion is one of hot topics in the field of chemistry. Molecular rotors have wide applications in building nanomachines and functional materials, due to their controllable rotations. Hence, the development of novel rotor systems, controlled by external stimuli, is desirable. Pillar[n]arenes, a class of macrocycles, have a unique planar chirality, in which two stable conformational isomers pR and pS would interconvert by oxygen-through-the-annulus rotations of their hydroquinone rings. We observe the differential kinetic traits of planar chirality transformation in sodium carboxylate pillar[5]arene (WP5-Na) and ammonium carboxylate pillar[5]arene (WP5-NH4), which inspire us to construct a promising rotary platform in anionic pillar[5]arenes (WP5) skeletons. Herein, we demonstrate the non-negligible effect of counter cations on rotational barriers of hydroquinone rings in WP5, which enables a cation grease/brake rotor system. Applications of this tunable rotor system as fluorescence switch and anti-counterfeiting ink are further explored.
Tailoring water structure with high-tetrahedral-entropy for antifreezing electrolytes and energy storage at −80 °C
Authors: Qiu Meijia , Sun Peng , Han Kai , Pang Zhenjiang , Du Jun , Li Jinliang , Chen Jian , Wang Zhong Lin , Mai Wenjie 
Published: February 2023

AbstractOne of unsolved puzzles about water lies in how ion-water interplay affects its freezing point. Here, we report the direct link between tetrahedral entropy and the freezing behavior of water in Zn2+-based electrolytes by analyzing experimental spectra and molecular simulation results. A higher tetrahedral entropy leads to lower freezing point, and the freezing temperature is directly related to the entropy value. By tailoring the entropy of water using different anions, we develop an ultralow temperature aqueous polyaniline| |Zn battery that exhibits a high capacity (74.17 mAh g−1) at 1 A g−1 and −80 °C with ~85% capacity retention after 1200 cycles due to the high electrolyte ionic conductivity (1.12 mS cm−1). Moreover, an improved cycling life is achieved with ~100% capacity retention after 5000 cycles at −70 °C. The fabricated battery delivers appreciably enhanced performance in terms of frost resistance and stability. This work serves to provide guidance for the design of ultralow temperature aqueous batteries by precisely tuning the water structure within electrolytes.