bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of hub genes and immune infiltration in ulcerative colitis using bioinformatics
Authors: Hu Weitao , Fang Taiyong , Zhou Mingxuan , Chen Xiaoqing 
Published: April 2023

AbstractUlcerative colitis (UC) is a chronic inflammatory disease of the intestine, whose pathogenesis is not fully understood. Given that immune infiltration plays a key role in UC progression, our study aimed to assess the level of immune cells in UC intestinal mucosal tissues and identify potential immune-related genes. The GSE65114 UC dataset was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between healthy and UC tissues were identified using the “limma” package in R, while their Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined with the clusterProfiler package. Protein–protein interaction network analysis and visualization were performed with STRING and Cytoscape. Immune cell infiltration was calculated with CIBERSORT. The relationship between hub genes and immune-infiltrated cells in UC was determined by Pearson correlation. A total of 206 DEGs were identified, of which 174 were upregulated and 32 downregulated. GO and KEGG functional classification indicated DEG enrichment in immune response pathways, including Toll-like receptor signaling, IL-17 signaling, and immune system process and chemokine signaling. 13 hub genes were identified. Infiltration matrix analysis of immune cells showed abundant plasma cells, memory B cells, resting CD4 memory T cells, γδ T cells, M0 and M1 macrophages, and neutrophils in UC intestinal tissues. Correlation analysis revealed 13 hub genes associated with immune-infiltrated cells in UC. 13 hub genes associated with immune-infiltrated cells in UC were identified; they included CXCL13, CXCL10, CXCL9, CXCL8, CCL19, CTLA4, CCR1, CD69, CD163, IL7R, PECAM1, TLR8 and TLR2. These genes could potentially serve as markers for the diagnosis and treatment of UC.
Collaborative training of medical artificial intelligence models with non-uniform labels
Authors: Tayebi Arasteh Soroosh , Isfort Peter , Saehn Marwin , Mueller-Franzes Gustav , Khader Firas , Kather Jakob Nikolas , Kuhl Christiane , Nebelung Sven , Truhn Daniel 
Published: April 2023

AbstractDue to the rapid advancements in recent years, medical image analysis is largely dominated by deep learning (DL). However, building powerful and robust DL models requires training with large multi-party datasets. While multiple stakeholders have provided publicly available datasets, the ways in which these data are labeled vary widely. For Instance, an institution might provide a dataset of chest radiographs containing labels denoting the presence of pneumonia, while another institution might have a focus on determining the presence of metastases in the lung. Training a single AI model utilizing all these data is not feasible with conventional federated learning (FL). This prompts us to propose an extension to the widespread FL process, namely flexible federated learning (FFL) for collaborative training on such data. Using 695,000 chest radiographs from five institutions from across the globe—each with differing labels—we demonstrate that having heterogeneously labeled datasets, FFL-based training leads to significant performance increase compared to conventional FL training, where only the uniformly annotated images are utilized. We believe that our proposed algorithm could accelerate the process of bringing collaborative training methods from research and simulation phase to the real-world applications in healthcare.
Identification of diagnostic biomarks and immune cell infiltration in ulcerative colitis
Authors: Chen Qin , Bei Shaosheng , Zhang Zhiyun , Wang Xiaofeng , Zhu Yunying 
Published: April 2023

AbstractWe aimed to explore diagnostic biomarks and immune cell infiltration characteristics in ulcerative colitis (UC). We used the dataset GSE38713 as the training set and dataset GSE94648 as the test set. A total of 402 differentially expressed genes (DEGs) were obtained from GSE38713. Annotating, visualizing, and integrating discovery of these differential genes was performed using Gene Ontology (GO), Kyoto Gene and Genome Encyclopedia Pathway (KEGG), and Gene Set Enrichment Analysis (GSEA). Protein–protein interaction networks were constructed from the STRING database, and protein functional modules were identified using the CytoHubba plugin of Cytoscape. Random forest and LASSO regression were used to screen for UC-related diagnostic markers, and ROC curves were generated to validate their diagnostic value. The composition of 22 immune cells was analyzed, and the immune cell infiltration in UC was analyzed using CIBERSORT. Results: Seven diagnostic markers associated with UC were identified: TLCD3A, KLF9, EFNA1, NAAA,WDR4, CKAP4, and CHRNA1. Immune cell infiltration assessment revealed that macrophages M1, activated dendritic cells, and neutrophil cells infiltrated relatively more compared to normal control samples. Our results suggest a new functional feature of UC and suggest potential biomarkers for UC through comprehensive analysis of integrated gene expression data.
Coping styles mediate the relation between mindset and academic resilience in adolescents during the COVID-19 pandemic: a randomized controlled trial
Authors: Janssen T. W. P. , van Atteveldt N. 
Published: April 2023

AbstractThe COVID-19 pandemic negatively impacted adolescent mental health on a global scale. However, many students were resilient during this crisis, despite exposure to COVID-related stressors. We aimed to study the protective effects of growth mindset on school-related resilience during the COVID-19 pandemic, and the mediating effects of coping styles. The two-year follow-up of an ongoing Randomized Controlled Trial, involving a growth mindset and control intervention, took place during the pandemic. We measured growth mindset, school burnout symptoms, COVID-19-specific stressor exposure, coping styles, and calculated a resilience score (corrected for pre-pandemic school burnout symptoms). Mediation analyses were performed in the total sample (N = 261), and exploratory in the intervention subsamples, to test whether the associations between mindset and resilience were mediated by coping styles. Growth-mindset students were more resilient during the pandemic and used less maladaptive and more adaptive (acceptance) coping styles. Coping mediated the relation between mindset and resilience in the total sample (both coping styles), and growth mindset intervention subsample (maladaptive coping). We found unique evidence for the beneficial effects of growth mindset on school-related resilience during the pandemic, and the mediating effect of coping styles as explanatory mechanism. This work contributes to a growing literature that shows positive effects of growth mindset on mental health.
NADcapPro and circNC: methods for accurate profiling of NAD and non-canonical RNA caps in eukaryotes
Authors: Sharma Sunny , Yang Jun , Favate John , Shah Premal , Kiledjian Megerditch 
Published: April 2023

AbstractAccurate identification of NAD-capped RNAs is essential for delineating their generation and biological function. Previous transcriptome-wide methods used to classify NAD-capped RNAs in eukaryotes contain inherent limitations that have hindered the accurate identification of NAD caps from eukaryotic RNAs. In this study, we introduce two orthogonal methods to identify NAD-capped RNAs more precisely. The first, NADcapPro, uses copper-free click chemistry and the second is an intramolecular ligation-based RNA circularization, circNC. Together, these methods resolve the limitations of previous methods and allowed us to discover unforeseen features of NAD-capped RNAs in budding yeast. Contrary to previous reports, we find that 1) cellular NAD-RNAs can be full-length and polyadenylated transcripts, 2) transcription start sites for NAD-capped and canonical m7G-capped RNAs can be different, and 3) NAD caps can be added subsequent to transcription initiation. Moreover, we uncovered a dichotomy of NAD-RNAs in translation where they are detected with mitochondrial ribosomes but minimally on cytoplasmic ribosomes indicating their propensity to be translated in mitochondria.
Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia
Authors: Martinez Jessy D. , Donnelly Marcus J. , Popke Donald S. , Torres Daniel , Wilson Lydia G. , Brancaleone William P. , Sheskey Sarah , Lin Cheng-mao , Clawson Brittany C. , Jiang Sha , Aton Sara J. 
Published: April 2023

AbstractStudies of primary visual cortex have furthered our understanding of amblyopia, long-lasting visual impairment caused by imbalanced input from the two eyes during childhood, which is commonly treated by patching the dominant eye. However, the relative impacts of monocular vs. binocular visual experiences on recovery from amblyopia are unclear. Moreover, while sleep promotes visual cortex plasticity following loss of input from one eye, its role in recovering binocular visual function is unknown. Using monocular deprivation in juvenile male mice to model amblyopia, we compared recovery of cortical neurons’ visual responses after identical-duration, identical-quality binocular or monocular visual experiences. We demonstrate that binocular experience is quantitatively superior in restoring binocular responses in visual cortex neurons. However, this recovery was seen only in freely-sleeping mice; post-experience sleep deprivation prevented functional recovery. Thus, both binocular visual experience and subsequent sleep help to optimally renormalize bV1 responses in a mouse model of amblyopia.
Dual‐loop antennas with an expanded axial ratio bandwidth
Authors: Hirose Kazuhide , Nishino Koki , Nakano Hisamatsu 
Published: April 2023

AbstractThe authors propose a novel dual‐wire antenna with a balanced feed to increase a 3‐dB axial ratio bandwidth. The antenna comprises loop elements with quasi two‐sources, and the effects of the element distance on the axial ratio bandwidth are revealed using the method of moments (MoM). It is found that the antenna has a maximum bandwidth of 41% at a distance of 0.15 wavelengths, three times as wide as that of an isolated loop element. Subsequently, the balanced feed is changed to a quasi‐balanced one using L‐figured parallel feedlines. It is found numerically and experimentally that the antenna shows an axial ratio bandwidth of 28%.
Research on the arcing horn with active arc extinguishing function for HVDC grounding electrode line
Authors: Liu Yicen , Yang Chenguang , Guo Yujun , Zhang Xueqin , Lei Xiao , Gao Guoqiang , Wu Guangning 
Published: April 2023

AbstractThe grounding electrode line is an important part of the Ultra high voltage direct current (UHVDC) transmission system. It acts as the channel to conduct the unbalanced current and the grounding current.The arcing horn consists of a pair of electrodes installed in parallel at both ends of the insulator string, which provides a discharge channel for the fault current by an air gap to protect the insulators. In this paper, the voltage and current distributions of the arcing horn were studied when the grounding electrode line was struck by lightning. It is found that the current and voltage gradually decrease along the direction from the converter station to the earth electrode. An active arc extinguishing method based on variable resistance for arcing horn was proposed. An electromagnetic transient simulation model of the grounding electrode line is established based on the electrical parameters of a ±800 kV UHVDC transmission system. It is found that the absorbed energy of the arc extinguishing unit needs to be at least 31.2 and 49.6 kJ when the lightning current is 20 and 50kA, respectively. According to the calculation results, the arcing horn with arc extinguishing unit was developed and tested. The test results verifies that the designed arcing horn can meet the requirements of engineering application.
Overall architecture and system design of shuttle unmanned ground vehicle with road verification in intelligent transportation system zone
Authors: Li Yuanzhe , Ni Jun , Hu Jibin 
Published: April 2023

AbstractThe shuttle unmanned ground vehicle (UGV) is an important element in the future intelligent transportation system (ITS), which will be widely used for public transportation in various scenarios. It has been widely accepted that the shuttle UGV will significantly improve the transportation efficiency and intelligent level of ITS in the near future. This paper presents an overall architecture and system of shuttle UGV for the future ITS. The hardware architecture includes sensor, actuator and computing platform, and is built on an X‐by‐wire chassis. The software architecture includes environment perception, decision making and dynamics control. Reliable and accurate autonomous driving algorithms are applied to the software system, which enable the shuttle UGV to drive intelligently and perform task stably. In addition, to address the large‐scale deployment of shuttle UGVs in the future, this paper also introduces the concept of cloud brain system and discusses the application and prospect of the cloud brain system in ITS. The cloud brain system can store, monitor and mine the big data generated by the shuttle UGVs, which will further improve the operational safety and overall performance of the shuttle UGV group. An open road test in an ITS test zone is conducted to validate the performance of the proposed overall architecture and system for the shuttle UGV.
A monolithic GaN driver with a deadtime generator (DTG) for high‐temperature (HT) GaN DC‐DC buck converters
Authors: Cui Miao , Zhu Yuhao , Cao Pingyu , Li Ang , Bu Qinglei , Mitrovic Ivona Z. , Su Xujun , Zhao Yinchao , Wen Huiqing , Liu Wen , Zhao Cezhou 
Published: April 2023

AbstractThis paper presents a monolithic GaN driver with a deadtime generator (DTG) for half‐bridge DC‐DC buck converters. The proposed GaN integrated circuits (ICs) were fabricated in a 3 µm enhancement‐mode GaN MIS‐HEMTs process. The integrated DTG converter can operate at 250°C with a large gate swing of 10 V, and it exhibits a maximum efficiency of 80% at high temperatures, with VIN= 30 V at 100 kHz. The monolithic GaN DTG driver requires one control signal and generates a deadtime of fewer than 0.13 µs at high temperatures up to 250°C. The proposed DTG converter is compared to an integrated GaN converter without DTG (w/o) under various conditions. At high temperatures, the optimized GaN DTG converter shows better performance than the GaN converter w/o at high load currents, in terms of smaller voltage overshoots and better efficiency as well. This work demonstrates a simple GaN deadtime method for high temperature (HT) GaN power converters.
Ultrasound of the lung
Authors: Dietrich Christoph F. , Görg Christian , Horn Rudolf , Prosch Helmut , Safai Zadeh Ehsan , Jenssen Christian 
Published: April 2023

AbstractThe CME review is intended to explain and discuss the clinical value of lung ultrasound but also to enable a pragmatically oriented approach by analyzing the clinical aspect. This includes knowledge of the pre-test probability, the acuteness of the disease, the current clinical situation, detection and/or characterization, initial diagnosis or follow up assessment and the peculiarities of exclusion diagnosis. Diseases of the pleura and lungs are described using these criteria with their direct and indirect sonographic signs and the specific clinical significance of ultrasound findings. The importance and criteria of conventional B-mode, color Doppler ultrasound with or without spectral analysis of the Doppler signal and contrast-enhanced ultrasound are discussed as well.
Ultraschallgestützte Hämodialyseshuntpunktion im nephrologischen Pflegealltag
Authors: Wichhardt Sandra 
Published: April 2023

ZUSAMMENFASSUNGShunts sind chirurgisch angelegte arteriovenöse Kurzschlussverbindungen, die bei Patient*innen mit einer terminalen Niereninsuffizienz zur Durchführung der Dialyse dienen. Im nephrologischen Pflegealltag ist die sogenannte Blindpunktion (Areal-, Strickleiter- oder Knopflochpunktion) des Shunts die gängigste Methode. Eine weitere Methode ist die ultraschallgestützte Punktion, wobei unter der Nutzung einer Ultraschallsonde der Shunt punktiert wird. In diesem Beitrag, der auf einer Facharbeit basiert, werden Techniken, Fallstricke, Vorteile und Nachteile einer ultraschallgestützten Shuntpunktion aus der Perspektive sowohl der Patient*innen als auch des Pflegepersonals dargestellt. Es erfolgt eine vergleichende Betrachtung der ultraschallgestützten Hämodialyseshuntpunktion mit Verfahren, die nicht bildgebungsassistiert sind. Die ultraschallgestützte Dialyseshuntpunktion ist ein geeignetes Instrument im Dialysealltag. Denn in der Facharbeit konnte gezeigt werden, dass die Zahl von Fehlpunktionen deutlich reduziert werden kann und sich somit die Patientensicherheit erhöhen lässt.
Reaction-norm analysis of neonatal lamb mortality suggests heritability varies with cold-stress: an example in the Elsenburg Merino selection lines
Authors: Nel C. L. , Steyn Y. , Gilmour A. R. , Waters D. , Clark S. A. , van der Werf J. H. J. , Swan A. A. , Dzama K. , Cloete S. W. P. 
Published: April 2023

Context Coping with high levels of cold stress should be beneficial to survival of lambs, given the high mortality rate associated with severe winter storms. The Elsenburg Merino selection experiment involved divergent selection for reproduction. Phenotypic results comparing the positively selected H-Lines and negatively selected L-Lines suggested that cold-stress adaption could have contributed to the favourable genetic trends for survival of H-Line lambs. However, observing the genetic merit of better adapted animals depends on the presence of cold stress at the time of recording. A genotype by environment component (G × E) could, thus, be important when assessing survival/mortality phenotypes. Aim This study proposed the genetic analysis of this possible G × E component and compared the H- and L-Lines in this regard. Methods The sire model allowed the use of progeny phenotypes for neonatal mortality recorded during different levels of cold stress, and the possible G × E could be investigated through the reaction-norm approach. Genetic parameters were evaluated as random regression components by implementing a Gibbs sampling approach. A data set of 5723 individual lamb records was analysed as the progeny of 213 sires. Results A modelled G × E component played an important role in mortality outcomes, with the mean estimate (and 95% confidence interval) for the slope ( σ s b 2 = 0.113 [ 0.0019 – 0.28 ] AN22464_IE1.gif) only marginally smaller than the corresponding estimate for the intercept ( σ s a 2 = 0.124 [ 0.003 – 0.26 ] AN22464_IE2.gif). The reaction-norm model showed a higher heritability (h2 ± posterior standard deviation) for mortality at 3 days of age during high cold-stress (0.22 ± 0.16 at ~1100 KJm−2h−1) than during mild (0.13 ± 0.10 at ~960 KJm−2h−1) conditions, suggesting a greater ability to discriminate between sires at increasing stress levels. Conclusions Failure to account for this G × E component putatively contributes to the low h2 commonly reported for survival traits. The higher h2 at increased levels of cold stress could have played an important part in the higher survival of the H-Line progeny, who were better at coping with cold, wet and windy conditions. Implications Larger studies representing a wider environmental trajectory are recommended. This should be very feasible since cold stress can be derived from commonly available weather-station data.
The role of regular engagement with non-companion animals and proximity to green and blue space for mental health, wellbeing, and loneliness during Covid-19 social-distancing measures: findings from a UK survey study
Authors: Shoesmith Emily , Ratschen Elena 
Published: April 2023

Context The Covid-19 pandemic led to increased use of green/blue space as indoor spaces became frequently inaccessible. These changes affected the direct interactions between humans and nature. Aims To investigate the links between mental health, loneliness, wellbeing, and interaction with non-companion animals, proximity to and use of green/blue space. Methods A cross-sectional online survey of adult UK residents was conducted between April and June 2020. The questionnaire included validated and bespoke items measuring demographics and exposures and outcomes related to mental health, wellbeing, loneliness, human–animal interactions with non-companion animals (wildlife/farm animals), and proximity to and use of green/blue space before and since the first UK Covid-19 lockdown. Key results Of 5926 participants, 4408 (74.4%) reported interacting with non-companion animals at least every other day. Frequent engagement with non-companion animals was significantly associated with smaller decreases in mental health scores (b = 0.131, 95% CI [0.007–0.256], P = 0.038) and smaller increases in loneliness scores (b = −0.135, 95% CI [−0.241–0.030], P = 0.012). Just under half (48.4%, n = 2867) reported living directly next to a green/blue space, and over half (52.3%; n = 3097) reported using such space at least every day since lockdown. Regular use of green/blue space since lockdown was significantly associated with higher mental health (b = 0.154, 95% CI [0.037–0.272], P = 0.010), lower loneliness (b = −0.334, 95% CI [−0.430 – −0.238], P = 0.001), and higher wellbeing (b = 0.810, 95% CI [0.572–1.047], P = 0.001). Closer proximity to such space was significantly associated with lower loneliness scores (b = −0.224, 95% CI [−0.319 – −0.130], P = 0.001), and higher wellbeing scores (b = 0.632, 95% CI [0.391–0.873], P = 0.001). Conclusion The multi-faceted human–nature relationship may promote key human health benefits in the context of the lockdown. Implications These findings have highlighted the importance of green/blue space and the human–animal relationship, and how they might play a critical role in maintaining people’s mental health within a pandemic context. Further targeted investigations relating to these areas and links with human health are important within both pandemic and non-pandemic contexts.
Mapping approach of ecosystem services for land-use decision planning in Africa
Authors: Alexis Akakpo Bokon , Akabassi Ghislain C. , Padonou Elie A. 
Published: April 2023

Abstract
Assessment of ecosystem services (ES) is vital for environmental sustainability and human wellbeing. A number of approaches are used to map the ES of a range of the types of ecosystems in various scope scales around the world. With a view of facilitating the scientific background to address the relevant methods of ES assessment, this review aims to highlight the characteristics of the studies carried out in Africa and make an idea on the recent approaches used for ES mapping. In total, 503 abstracts were reviewed to identify the relevant publications from which 48 publications were used for the review. Model-based mapping, Proxy indicators-based mapping, Remote sensing (RS) and GIS-based mapping and Expert-based mapping approaches have been found to be applied to map ES in Africa. The approach of RS and GIS basis technics was generally predominated (56.25%) where studies on wetlands and mangrove ecosystems (44.44%) and at the local scale (70.37%) were mostly documented. The domain of ES dynamics (52.94%), ES supply (41.18%) and environmental change (34.29%) were largely addressed. Excluding articles because of 10-year publications could reduce some information related to the purpose of the review. However, the evidence provided in this document represents a significant step forward in ES mapping and conservation efforts to improve the sustainability of ES in Africa.
Phytopythium vexans (de Bary) Abad, de Cock,Bala, Robideau, Lodhi & Lévesque
Authors: CABI  , EPPO  
Published: April 2023

Abstract
A new distribution map is provided for Phytopythium vexans (de Bary) Abad, de Cock,Bala, Robideau, Lodhi & Lévesque. Oomycetes: Pythiales: Pythiaceae. Hosts: Numerous.