bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are pediatricians responsible for maintaining high MMR vaccination coverage? Nationwide survey on parental knowledge and attitudes towards MMR vaccine in Serbia
Authors: Loncarevic Goranka S. , Jovanovic Aleksa Lj , Kanazir Milena S. , Kisic Tepavcevic Darija B. , Maric Gorica D. , Pekmezovic Tatjana D. 
Published: February 2023

Aim
To assess parental knowledge and attitudes related to MMR vaccination and to determine factors associated with parental decision whether to vaccinate their child with MMR vaccine in Serbian population.

Methods
The selection of participants was performed using multi-phase sampling. Seventeen out of the total 160 public health centers on the territory of Republic of Serbia were randomly selected. All parents of children up to the age of 7 who visited the pediatrician at the public health centers from June to August 2017 were recruited. Parents filled in an anonymous questionnaire regarding their knowledge, attitudes and practices in immunization with MMR vaccine. The relative contribution of different factors was explored by univariable and multivariable logistic regression analysis.

Results
The majority of parents were female (75.2%), with mean age of 34.3 ± 5.7 years, and the average age of children was 4.7 ± 2.4 years, 53.7% of them were girls. In the multivariable model, getting information on vaccination from a pediatrician was associated with 7.5 fold increased probability to vaccinate child with MMR vaccine (OR = 7.52; 95% CI 2.73–20.74; p<0.001), while previous vaccination of the child increased this chance two times (OR = 2.07; 95% CI 1.01–4.27; p = 0.048), and having two children was associated with 84% increase in chance of vaccinating child with MMR vaccine compared to having one child or three or more children (OR = 1.84; 95% CI 1.03–3.29; p = 0.040).

Conclusion
Our study emphasized the key role of pediatricians in the formation of parental attitude on MMR vaccination of their child.
Determinants of good vitamin A consumption in the 12 East Africa Countries using recent Demographic and health survey
Authors: Wolde Maereg , Tessema Zemenu Tadesse 
Published: February 2023

Background
Vitamin A one of the important micronutrients that it cannot be made in the human body and must be taken from outside the body through the diet. Ensuring that vitamin A is available in any form in sufficient quantities remains a challenge, especially in regions where access to vitamin A-containing foods and healthcare interventions is limited. As a result, vitamin A deficiency (VAD) becomes a common form of micronutrient deficiency. To the best of our knowledge, there is limited evidence on determinants of good Vitamin A consumption in East African countries. Therefore, this study aimed to assess the magnitude and determinants of good vitamin A consumption in East African countries.

Methods
A recent Demographic and Health Survey (DHS) of twelve East African countries were included to determine the magnitude and determinants of good vitamin A consumption. A total of 32,275 study participants were included in this study. A multilevel logistic regression model was used to estimate the association between the likelihood of good vitamin A-rich food consumption. Both community and individual levels were used as independent variables. Adjusted odds ratio and its 95% confidence interval were used to see the strength of the association.

Result
The pooled magnitude of good vitamin A consumption was 62.91% with a 95% CI of 62.3 to 63.43. The higher proportion of good vitamin A consumption 80.84% was recorded in Burundi and the smallest good vitamin A consumption 34.12% was recorded in Kenya. From the multilevel logistic regression model, women’s age, marital status, maternal education, wealth index, maternal occupation, children’s age in a month, media exposure, literacy rate, and parity were significantly associated with good vitamin A consumption in East Africa.

Conclusion
The magnitude of good vitamin A consumption in twelve East African countries is low. To increase good vitamin A consumption health education through the mass media and enhancing the economic status of women is recommended. Planners and implementers should give attention and priority to identified determinants to enhance good vitamin A consumption.
Serological and histopathological assessment of galactose-deficient immunoglobulin A1 deposition in kidney allografts: A multicenter prospective observational study
Authors: Sofue Tadashi , Oguchi Hideyo , Yazawa Masahiko , Tsujita Makoto , Futamura Kenta , Nishihira Morikuni , Toyoda Mariko , Kano Toshiki , Suzuki Hitoshi 
Published: February 2023

Background
Recurrent immunoglobulin A (IgA) nephropathy is an important risk factor for kidney allograft loss. However, there is no classification system for IgA deposition in kidney allografts based on serological and histopathological evaluation of galactose-deficient IgA1 (Gd-IgA1). This study aimed to establish a classification system for IgA deposition in kidney allografts based on serological and histological evaluation of Gd-IgA1.

Methods
This multicenter prospective study included 106 adult kidney transplant recipients in whom an allograft biopsy was performed. Serum and urinary Gd-IgA1 levels were investigated in 46 transplant recipients who were IgA-positive and classified into four subgroups according to the presence or absence of mesangial Gd-IgA1 (KM55 antibody) deposits and C3.

Results
Minor histological changes without an acute lesion were observed in recipients with IgA deposition. Fourteen (30%) of the 46 IgA-positive recipients were KM55-positive and 18 (39%) were C3-positive. The C3 positivity rate was higher in the KM55-positive group. Serum and urinary Gd-IgA1 levels were significantly higher in KM55-positive/C3-positive recipients than in the other three groups with IgA deposition. Disappearance of IgA deposits was confirmed in 10 of 15 IgA-positive recipients in whom a further allograft biopsy was performed. The serum Gd-IgA1 level at the time of enrollment was significantly higher in recipients in whom IgA deposition continued than in those in whom it disappeared (p = 0.02).

Conclusions
The population with IgA deposition after kidney transplantation is serologically and pathologically heterogeneous. Serological and histological assessment of Gd-IgA1 is useful for identifying cases that should be carefully observed.
Sticky cost determinants: Which one has the stronger impact?
Authors: Soegiharto Michelle , Rachmawati Dyna 
Published: February 2023

Sticky cost is a phenomenon that can occur in companies and it is an unbalanced response of costs to changes in output. Since it can reduse company profits, it should not occur. Therefore, it is important to know the determinants that influence it so that the company can control properly redusing it. The aim of this research is to test which the determinants that have the impact of Covid-19, asset intensity, employee intensity, equity intensity, management incentives, profitability, and intellectual capital on sticky cost.This research is a quantitative research with Â object of manufacturing companies listed on the Indonesia Stock Exchange with observation period of 2019-2020. This research uses financial data from annual report and summary of minutes General Meeting of Shareholders. The sample selection technique used purposive sampling method. This research involved two data analysis techniques. There are multiple linear regression for main test and logistic regression for additional test. The results of the main test show that employee intensity and intellectual capital have impact on sticky cost. But, the Covid-19, asset intensity, equity intensity, management incentives, and profitability have no impact on sticky cost. The main test result is supported by the additional test, in term of first, intellectual capital has impact on sticky cost. Second, the other determinants remain no impact on sticky cost. The implications of this research are management should be carefull to make investment in intangible assets and use employee intensive. As those determinants can increase sticky cost.
The effect of covid-19 on bank proftability: Evidence of m-banking and e-banking in Indonesia
Authors: Anggraeni Anggraeni , Basuki Basuki , Setiawan Rahmat 
Published: February 2023

Covid-19 affected the banksâ€™ financial acitivities globally and, therefore, mobile banking can become solution for doing a distancing transaction. This study tries to observe if mobile transaction has significant effect of income in private and public bank in Indonesia. This study collects the data about bank profitability and the number of mobile banking users before and during Covid-19 pandemic from BCA and BNI in Indonesia. The data of mobile transaction is divided into three, mobile, internet, and SMS banking. The data of income divided into two, premium/net and operational income. The data is analyzed using linear regression method to observe if mobile transaction has effect toward income variables. The data is analyzed using SPSS. The result showed that before pandemic, those three mobile transaction have strong correlation toward the increasing number of net and total operational income in BNI. In BCA, mobile banking has a significant effect on net and total operational income. During pandemic, mobile transactions have negative correlation toward net income, while operational income has positive one for BNI, but negative for BCA. It can be concluded that Â internet, mobile, and SMS banking have correlation toward net and total operational income.
Metallogenic model of the Hongqiling Cu–Ni sulfide intrusions, Central Asian Orogenic Belt: Insight from long-period magnetotellurics
Authors: Xu Zhi-He , Gu Guan-Wen , Jiang Ji-Yi , Li Fei-Da , Niu Xing-Guo 
Published: February 2023

Abstract
The Hongqiling magmatic Cu–Ni sulfide deposit is one of the most important deposits in the easternmost segment of the Central Asian Metallogenic Belt, northeast China. However, the existence or non-existence of magmatic chambers is still not been determined, which is the key to decipher the formation of Hongqiling Cu–Ni deposit. Therefore, this study proposes to adopt long-period magnetotellurics method to image the deep-seated metallogenic system in Hongqiling Cu–Ni deposit. Two-dimensional (2D) nonlinear conjugate gradient inversion technology allows us to describe entire magma plumbing system, including the mantle-derived magma channels (banded low-resistivity anomalies), deep separated chamber (low-resistivity anomaly C2), and shallow magma conduits (low-resistivity anomaly C1). These results indicated that the mantle-derived primitive magma gave rise to the parental magma for the mafic–ultramafic intrusions in Hongqiling Cu–Ni deposit and triggered the segregation of Cu–Ni sulfides in the shallow chamber. By combining the experimental simulation, geochemistry, geochronology, and geotectonics data in the study area, we suggest that the partial melting processes which produced the large magma plumbing system probably have been triggered by lithospheric delamination.
Die Seidenstraßeninitiative in deutschen Medien – eine frameanalytische Langzeitstudie
Authors: Wang Yuanmeng 
Published: February 2023

Zusammenfassung
In den letzten Jahren verfolgen die deutschen Medien die chinesische „Seidenstraßeninitiative“ mit steigender Aufmerksamkeit. Dieser Artikel führt eine diachrone Analyse der relevanten Berichte über das Thema „Seidenstraßeninitiative“ von fünf deutschen Nachrichtenmedien im Zeitraum von 2013 bis 2020 durch. Ziel dieser systematischen Untersuchung der deutschen Presseberichterstattung ist, die Veränderung der Medienframes zur „Seidenstraßeninitiative“ in deutschen Berichterstattungen zu analysieren. Das Ergebnis der Studie zeigt, dass die Medienframes der „Seidenstraßeninitiative“ in den deutschen Medien im Laufe der Zeit eine Dynamik in ihrer Stabilität und der Negativierung aufweisen.
Evaluation and analysis of teaching quality of university teachers using machine learning algorithms
Authors: Zhong Ying 
Published: February 2023

Abstract
In order to better improve the teaching quality of university teachers, an effective method should be adopted for evaluation and analysis. This work studied the machine learning algorithms and selected the support vector machine (SVM) algorithm to evaluate teaching quality. First, the principles of selecting evaluation indexes were briefly introduced, and 16 evaluation indexes were selected from different aspects. Then, the SVM algorithm was used for evaluation. A genetic algorithm (GA)-SVM algorithm was designed and experimentally analyzed. It was found that the training time and testing time of the GA-SVM algorithm were 23.21 and 7.25 ms, both of which were shorter than the SVM algorithm. In the evaluation of teaching quality, the evaluation value of the GA-SVM algorithm was closer to the actual value, indicating that the evaluation result was more accurate. The average accuracy of the GA-SVM algorithm was 11.64% higher than that of the SVM algorithm (98.36 vs 86.72%). The experimental results verify that the GA-SVM algorithm can have a good application in evaluating and analyzing teaching quality in universities with its advantages in efficiency and accuracy.
Improving binary crow search algorithm for feature selection
Authors: Hamed Alnaish Zakaria A. , Algamal Zakariya Yahya 
Published: February 2023

Abstract
The feature selection (FS) process has an essential effect in solving many problems such as prediction, regression, and classification to get the optimal solution. For solving classification problems, selecting the most relevant features of a dataset leads to better classification accuracy with low training time. In this work, a hybrid binary crow search algorithm (BCSA) based quasi-oppositional (QO) method is proposed as an FS method based on wrapper mode to solve a classification problem. The QO method was employed in tuning the value of flight length in the BCSA which is controlling the ability of the crows to find the optimal solution. To evaluate the performance of the proposed method, four benchmark datasets have been used which are human intestinal absorption, HDAC8 inhibitory activity (IC50), P-glycoproteins, and antimicrobial. Accordingly, the experimental results are discussed and compared against other standard algorithms based on the accuracy rate, the average number of selected features, and running time. The results have proven the robustness of the proposed method relied on the high obtained value of accuracy (84.93–95.92%), G-mean (0.853–0.971%), and average selected features (4.36–11.8) with a relatively low computational time. Moreover, to investigate the effectiveness of the proposed method, Friedman test was used which declared that the performance supremacy of the proposed BCSA-QO with four datasets was very evident against BCSA and CSA by selecting the minimum relevant features and producing the highest accuracy classification rate. The obtained results verify the usefulness of the proposed method (BCSA-QO) in the FS with classification in terms of high classification accuracy, a small number of selected features, and low computational time.
Transient response and performance of prestressed concrete deep T-beams with large web openings under impact loading
Authors: Abbas Rafaa M. , Hussein Lara T. 
Published: February 2023

Abstract
This study reports testing results of the transient response of T-shape concrete deep beams with large openings due to impact loading. Seven concrete deep beams with openings including two ordinary reinforced, four partially prestressed, and one solid ordinary reinforced as a reference beam were fabricated and tested. The effects of prestressing strand position and the intensity of the impact force were investigated. Two values for the opening’s depth relative to the beam cross-section dimensions were inspected under the effect of an impacting mass repeatedly dropped from different heights. The study revealed that the beam’s transient deflection was increased by about 50% with greater amplitudes for response oscillations due to impact loading as the impact force increased twice. The results showed that the transient strains in the reinforcement and concrete increased when increasing the opening depth with higher amplitudes for the response oscillations, whereas it had a minimal effect on the beam’s transient deflection. The reinforcement and concrete strain results indicated a higher damping for the strains as the prestressing strands were introduced. Comparison with solid deep beam response showed remarkable increase in the beam deflection and strains with greater amplitudes for response oscillations when large openings were introduced in the web.
Effects of cellulose nanofibers on flexural behavior of carbon-fiber-reinforced polymer composites with delamination
Authors: Liu Ran , Shen Gongtian , Zhang Pengfei , Yang Sa , Zhou Wei , Ye Chao , Li Qing 
Published: February 2023

Abstract
Understanding the influence of delamination defects on the damage evolution behavior of carbon-fiber-reinforced polymers (CFRPs) is crucial to improve their engineering applications. This study examined the flexural damage behaviors of CFRP composites by using a combination of acoustic emission (AE) and X-ray micro-computed tomography (micro-CT). Four specimens with different delamination defects and 0.1 wt% cellulose nanofibers (CNFs) were subjected to three-point bending tests. AE was employed to monitor the loading process, and then, micro-CT was utilized to detect the internal damage. The results showed that for the specimens with preset delamination defects near the surface, CNF-reinforced specimen exhibited no obvious enhancement effect on bending strength, and its cumulative acoustic energy decreased by 28% compared with that of CFRP specimens. For the specimen with preset delamination damage in the middle position, CNFs had an obvious enhancement effect on mechanical behavior, and the cumulative acoustic energy decreased by 43%. No obvious kink band was observed in the CNF-reinforced specimens, and during crack propagation, causing cracking and delamination damage was difficult. The results of micro-CT are consistent with those of AE. The results combined the combination of AE and micro-CT reflect the superiority of the hybrid detection system.
Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10
Authors: Richter Felix Clemens , Friedrich Matthias , Kampschulte Nadja , Piletic Klara , Alsaleh Ghada , Zummach Ramona , Hecker Julia , Pohin Mathilde , Ilott Nicholas , Guschina Irina , Wideman Sarah Karin , Johnson Errin , Borsa Mariana , Hahn Paula , Morriseau Christophe , Hammock Bruce D , Schipper Henk Simon , Edwards Claire M , Zechner Rudolf , Siegmund Britta , Weidinger Carl , Schebb Nils Helge , Powrie Fiona , Simon Anna Katharina 
Published: February 2023

AbstractLipids play a major role in inflammatory diseases by altering inflammatory cell functions, either through their function as energy substrates or as lipid mediators such as oxylipins. Autophagy, a lysosomal degradation pathway that limits inflammation, is known to impact on lipid availability, however, whether this controls inflammation remains unexplored. We found that upon intestinal inflammation visceral adipocytes upregulate autophagy and that adipocyte‐specific loss of the autophagy gene Atg7 exacerbates inflammation. While autophagy decreased lipolytic release of free fatty acids, loss of the major lipolytic enzyme Pnpla2/Atgl in adipocytes did not alter intestinal inflammation, ruling out free fatty acids as anti‐inflammatory energy substrates. Instead, Atg7‐deficient adipose tissues exhibited an oxylipin imbalance, driven through an NRF2‐mediated upregulation of Ephx1. This shift reduced secretion of IL‐10 from adipose tissues, which was dependent on the cytochrome P450‐EPHX pathway, and lowered circulating levels of IL‐10 to exacerbate intestinal inflammation. These results suggest an underappreciated fat‐gut crosstalk through an autophagy‐dependent regulation of anti‐inflammatory oxylipins via the cytochrome P450‐EPHX pathway, indicating a protective effect of adipose tissues for distant inflammation.
Reverse electron transfer is activated during aging and contributes to aging and age‐related disease
Authors: Rimal Suman , Tantray Ishaq , Li Yu , Pal Khaket Tejinder , Li Yanping , Bhurtel Sunil , Li Wen , Zeng Cici , Lu Bingwei 
Published: February 2023

AbstractMechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species (ROS) in aging and age‐related disorders remain poorly defined. We show that reverse electron transfer (RET) at mitochondrial complex I, which causes increased ROS production and NAD+ to NADH conversion and thus lowered NAD+/NADH ratio, is active during aging. Genetic or pharmacological inhibition of RET decreases ROS production and increases NAD+/NADH ratio, extending the lifespan of normal flies. The lifespan‐extending effect of RET inhibition is dependent on NAD+‐dependent Sirtuin, highlighting the importance of NAD+/NADH rebalance, and on longevity‐associated Foxo and autophagy pathways. RET and RET‐induced ROS and NAD+/NADH ratio changes are prominent in human induced pluripotent stem cell (iPSC) model and fly models of Alzheimer's disease (AD). Genetic or pharmacological inhibition of RET prevents the accumulation of faulty translation products resulting from inadequate ribosome‐mediated quality control, rescues relevant disease phenotypes, and extends the lifespan of Drosophila and mouse AD models. Deregulated RET is therefore a conserved feature of aging, and inhibition of RET may open new therapeutic opportunities in the context of aging and age‐related diseases including AD.
Dose-dependent response to long-term clomiphene citrate in male functional hypogonadotropic hypogonadism
Authors: Lin Beryl , Twigg Stephen M 
Published: February 2023

Summary
Functional hypogonadotropic hypogonadism is a relatively common condition in middle-aged to elderly men that can significantly impair quality of life. Besides lifestyle optimisation, androgen replacement remains the mainstay of treatment; however, its adverse effects on spermatogenesis and testicular atrophy are undesirable. Clomiphene citrate is a selective oestrogen receptor modulator that acts centrally to increase endogenous testosterone without affecting fertility. Although it has demonstrated effectiveness in shorter-duration studies, its longer-term outcomes are less well-documented. In this study, we report the case of a 42-year-old male with functional hypogonadotropic hypogonadism who sustained an excellent dose-dependent, titratable clinical and biochemical response to clomiphene citrate with no known adverse effects for 7 years to date. This case highlights that clomiphene citrate has potential as a safe and titratable longer-term treatment option, and the need for further randomised control trials in therapy options to normalise androgen status.

Learning points

Functional hypogonadotropic hypogonadism is a relatively common, but likely underdiagnosed, condition in middle-aged to older males.

Testosterone replacement is the current mainstay of endocrine therapy but can cause sub-fertility and testicular atrophy.

Clomiphene citrate is a serum oestrogen receptor modulator that acts centrally to increase endogenous testosterone production without affecting fertility.

It has potential as a safe and efficacious longer-term treatment option that can be titrated to increase testosterone and relieve clinical symptoms in a dose-dependent manner.

Longitudinal prospective studies as randomised control trials evaluating alternatives to exogenous testosterone are required.