bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants
Authors: Qiu Jun , Wu Sha , Huang Ruiwen , Liao Zhenyu , Pan Xiongfeng , Zhao Kunyan , Peng Yunlong , Xiang Shiting , Cao Yunhui , Ma Ye , Xiao Zhenghui 
Published: January 2025

BackgroundAntibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.ObjectivesTo explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.MethodsA total of 72 infants were included in the study. We performed 16S rRNA sequencing on stool swab samples collected from neonatal intensive care unit patients who received amoxicillin-clavulanic acid (AC, n = 10), moxalactam (ML, n = 28) and non-antibiotics (NA, n = 34). We then compared the taxonomic composition between treatment regimens, focusing on differences in butyrate-producers.ResultsOur study showed that there were significant differences in Shannon index (p = 0.033) and Beta diversity (p = 0.014) among the three groups. At the family level, compared with the other two groups, the relative abundance of Clostridiaceae (p &lt; 0.001) and Veillonellaceae (p = 0.004) were significantly higher, while the relative abundance of Enterococcidae (p &lt; 0.001) was significantly lower in the NA group. The relative abundance of Enterobacteriaceae (p = 0.022) in the AC group was greater than that in the other two groups. Additionally, butyrate-producers (p &lt; 0.001), especially Clostridiaceae (p &lt; 0.001), were noticeably more abundant in the NA group. The relative abundance of Clostridiaceae and butyrate-producers were the lowest in the ML group (p &lt; 0.001).ConclusionWe found that antibiotic therapy had an adverse impact on the initial development of gut microbiota and leaded to a reduction in the abundance of butyrate-producers, particularly Clostridiaceae. Furthermore, moxalactam had a more pronounced effect on the gut microbiota compared to amoxicillin-clavulanic acid.
Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study
Authors: Griffith Owen , Bai Xiaoxiao , Walter Alexa E. , Gay Michael , Kelly Jon , Sebastianelli Wayne , Papa Linda , Slobounov Semyon 
Published: January 2025

IntroductionResting state-fMRI, provides a sensitive method for detecting changes in brain functional integrity, both with respect to regional oxygenated blood flow and whole network connectivity. The primary goal of this report was to examine alterations in functional connectivity in collegiate American football players after a season of repetitive head impact exposure.MethodsCollegiate football players completed a rs-fMRI at pre-season and 1 week into post-season. A seed-based functional connectivity method, isolating the posterior cingulate cortex (PCC), was utilized to create individual functional connectivity maps. During group analysis, first, voxel-wise paired sample t-tests identified significant changes in connectivity from pre- to post-season, by player, and previous concussion history. Second, 10 DMN ROIs were constructed by overlaying an anatomical map over regions of positive correlation from one-sample t-tests of pre-season and post-season. These ROIs, plus the LpCun, were included in linear mix-effect modeling, with position or concussion history as covariates.Results66 players were included (mean age 20.6 years; 100% male; 34 (51.5%) non-speed position players). The 10 DMN ROIs showed no alterations from pre-season to post-season. By concussion history, the right temporal ROI demonstrated a significant effect on baseline functional connectivity (p = 0.03). Speed players, but not non-speed players, demonstrated a significant decrease in functional connectivity in the precuneus from pre- to post-season (p &lt; 0.001).DiscussionThere are region-specific differences functional connectivity related to both position and concussion history in American collegiate football players. Player position affected functional connectivity across a season of football. Position-specific differences in head impact exposure rate and magnitude plays a crucial role in functional connectivity alterations.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis
Authors: Chen Yonghu , Wu Xilin , Jiang Zhe , Li Xuezheng 
Published: January 2025

BackgroundAcute lung injury (ALI) is a severe condition characterized by inflammation, tissue damage, and persistent activation of the cyclic GMP-AMP (cGAS)-stimulator of interferon genes (STING) pathway, which exacerbates the production of pro-inflammatory mediators and promotes the progression of ALI. Specific inhibition of this pathway has been shown to alleviate ALI symptoms. Kaempferol-3-O-α-L-(4″-E-p-coumaroyl)-rhamnoside (KAE), an active compound found in the flowers of Angelica acutiloba Kitagawa, exhibits anti-inflammatory and antioxidant properties. This study aimed to investigate the molecular mechanisms through which KAE regulates the cGAS-STING pathway in the context of ALI.MethodsALI was induced using LPS. Lung damage and anti-inflammatory/antioxidant effects were assessed by H&amp;E staining, lung edema index, and SOD, MDA, and ELISA assays. NO release and mitochondrial membrane potential (MMP) were measured by JC-1 and Griess methods. The impact of KAE on the cGAS-STING pathway and PANoptosis was analyzed using flow cytometry, Western blot, and immunofluorescence.ResultsKAE significantly alleviated lipopolysaccharide-induced pulmonary injury by reducing inflammatory cell infiltration, alleviating pulmonary edema, enhancing antioxidant capacity, and decreasing levels of inflammatory cytokines in mouse lung tissues. In both in vitro and in vivo analyses, KAE downregulated the expression of key components of the cGAS-STING pathway, including cGAS, STING, p-TBK1, and nuclear factor-κB. KAE also reduced the assembly and activation of the PANoptosome, thereby attenuating apoptosis, necroptosis, and pyroptosis. Additionally, KAE inhibited cGAS activation by restoring the MMP, which reduced the release of cytosolic DNA.ConclusionKAE improve ALI by inhibiting the release of cytosolic DNA and suppressing cGAS-STING pathway activation, thereby protecting cells from PANoptosis. Our findings provide valuable insights for the development and application of novel therapeutic strategies for ALI.
Early childhood deprivation and the impact of negative life events on mental health in later life: a test of the stress sensitization hypothesis
Authors: Rizeq Jala , Kennedy Mark , Miseih Kirellos , Liao Wangjingyi , Sonuga-Barke Edmund J. S. 
Published: January 2025

IntroductionEarly life exposure to adversity and stress has been shown to sensitize young people to later negative life events (LEs), leading to increased susceptibility to mental health problems. We explored this question by testing whether exposure to severe institutional deprivation moderated the effect of adolescent exposure to LE on early adult depression and anxiety. To test the specificity of these effects, we contrasted the effects on these outcomes with neuro-developmental problems (autism and disinhibited social engagement), known from previous studies to be associated with deprivation from early childhood.MethodsParticipants were 170 adoptees from the English and Romanian Adoptees study. Of these, 124 (66 females) grew up as infants and small children in severely depriving Romanian orphanages before being adopted into UK families before the age of 43 months. The remainder were UK adoptees (16 females) with no history of deprivation who were placed before the age of 6 months. For this analysis, data on emotional problems, autism, and disinhibited social engagement were used at both age 15 years and in early adulthood (23–25 years) using standardized questionnaire and interview measures. Exposure to independent, dependent, and peer-related LE was measured at age 15 years.ResultsIn all models, there were continuities in all outcomes between adolescence and adulthood (ps &lt; .05). Dependent LE had a main effect on emotional symptoms, with higher exposure to dependent LE predicting an increase in emotional symptoms between age 15 and young adulthood. For independent and dependent LE, there were no interactions between deprivation and LE. For peer-related LE, the interaction was significant for emotional problems, but not deprivation-specific problems (i.e., autism/disinhibited social engagement)—the group of individuals exposed to early extreme deprivation and elevated peer-related LE had elevated emotional problems.DiscussionThere was no evidence that early severe institutional deprivation increased susceptibility to depression and anxiety following exposure to independent or dependent LE in general. However, it appeared to sensitize adolescents to the effects of peer-related LE specifically. We discuss possible mechanisms by which difficulties in peer relations might influence the emergence of depression and anxiety to already vulnerable individuals.
Awareness of lung cancer among urban residents in Sichuan Province and its impact on their willingness to choose medical institutions for cancer screening
Authors: Chai Qi , Li Ruicen , Bao Ting , Yang Zhibo , Liu Qing , Chen Feng 
Published: January 2025

IntroductionThis study aimed to investigate the current level of knowledge about lung cancer among urban residents in Sichuan Province and to assess its influence on their willingness to choose county-level or lower-level medical institutions for cancer screening.MethodsA total of 31,184 urban residents of Sichuan Province were included in the cross-sectional study. Binary logistic regression and propensity score matching (PSM) were used to assess the influence effect.ResultsThe results showed that (1) only 23.88% of the residents self-reported having good knowledge about lung cancer. They mainly acquired knowledge from the media (43%) and medical staff (42%). Only 33.5% of the participants had undergone lung cancer screening, with the main reasons being periodic physical examinations (54%) and physician recommendations (23%). (2) Binary logistic regression analysis revealed that knowledge of lung cancer was significantly associated with the participants’ willingness to undergo lung cancer screening at county-level or lower-level medical institutions [OR = 1.185, 95% CI (1.113 -1.263), p &lt; 0.001]. (3) Using PSM, it was found that the willingness of residents who had good knowledge of lung cancer-related topics increased by 2.8% after using kernel matching, by 3.1% after using one-to-one nearest neighbor matching, and by 2.4% after using radius matching with a caliper size of 0.001. (4) After stratifying by psychological status, we found that among residents with unstable psychological status, the willingness of those who had good knowledge of lung cancer increased by 5.3% after using kernel matching, by 3.6% after using one-to-one nearest neighbor matching, and by 4.9% after using radius matching with a caliper size of 0.001.DiscussionImproving urban residents’ understanding of the disease could help improve the current situation of hierarchical diagnosis and treatment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024556625.
Effects of tai chi based on information and communication technology for patients with mild cognitive impairment on cognitive and physical function: a systematic review and meta-analysis
Authors: Li Yezi , Wang Qingjie , Ren Yuanyuan , Mao Xiaokun 
Published: January 2025

ObjectiveThis study evaluated the effectiveness of tai chi, enhanced by communication technologies, in improving cognitive and physical functioning in patients with mild cognitive impairment, and to compare these effects with traditional tai chi.MethodsA systematic search across four academic databases identified 16 studies with 1,877 participants. Data were expressed as weighted or standardized mean differences with 95% confidence intervals.ResultsA meta-analysis revealed significant improvements in Mini-Mental State Examination scores and Timed Up and Go results in patients with mild cognitive impairment following tai chi intervention. Subgroup analysis indicated that both communication technology-based tai chi and traditional tai chi produced varying improvements in cognitive and physical function.ConclusionThis study confirms the importance of tai chi for cognitive and physical functioning in patients with mild cognitive impairment. Compared with traditional tai chi, communication technology-based tai chi showed greater benefits in promoting rehabilitation. The effective and feasible interventions could improve the physical health of many older adult patients, these findings provide valuable insights and decision-making guidance for clinical practice and public health with older patients with mild cognitive impairment.Systematic review registrationPROSPERO, CRD42023449711, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023449711.
Observational cohort study of a group-based VR program to improve mental health and wellbeing in people with life-threatening illnesses
Authors: Kettner Hannes , Glowacki David R. , Wall Justin , Carhart-Harris Robin L. , Roseman Leor , Hardy Joseph L. 
Published: January 2025

IntroductionBeing diagnosed with a life-threatening illness (LTI) is often accompanied by feelings of fear, uncertainty, and loneliness that can severely impact mental health. Relatively few interventions are available to address the existential concerns of individuals facing LTI, while treatment of the underlying physical ailment typically remains the priority of the healthcare system. Research has shown that psychedelic-assisted psychotherapy (PAT) holds promise for supporting mental health in people with LTIs. However, PAT’s potential in this population remains curtailed by several limitations, including regulatory and accessibility issues. Novel approaches that could provide some of the benefits of psychedelic experiences, while avoiding associated challenges, would therefore be highly desirable for supporting the mental wellbeing of people with LTIs. Among such interventions, virtual reality (VR)-based experiences have been suggested as a promising candidate. We here evaluate a program that includes weakly representational, multi-user VR experiences based on a design aesthetic previously described as “numadelic,” which has been demonstrated to elicit self-transcendent experiences comparable to psychedelics.MethodsA prospective cohort study design was used to assess the effects of “Clear Light” (CL), a group-based, 6-session multimedia program that included VR experiences, video calls, and text chats spanning 3 weeks. Participants were individuals suffering from LTIs that self-selected to participate in the CL program. A total of N = 15 participants were evaluated based on assessments 1 week before and after the program, using self-report measures of anxiety, depression, wellbeing, and secondary psychological outcomes.ResultsThe intervention was well-tolerated among participants. Significant improvements with moderate effect sizes were observed on self-reported measures of anxiety, depression, and wellbeing. Secondary measures assessing demoralization, connectedness, and spiritual wellbeing also showed significant improvements.DiscussionThis observational study demonstrated the feasibility and potential benefits of a group-based VR program that can be delivered at-home to people suffering from LTIs. While conclusions are presently limited by the lack of randomization or a comparison group, our findings strongly suggest further research is warranted, including randomized controlled trials.
Uma sequência didática para o estudo da análise combinatória no ensino médio
Authors: Coimbra Jhonatan Filipe Neves , Alves Manuela Lima Guimarães , Costa Acylena Coelho 
Published: January 2025

Este artigo apresenta uma investigação cujo objetivo foi verificar as contribuições da aplicação de uma Sequência Didática para o processo de ensino e aprendizagem da Análise Combinatória. O embasamento teórico foi centrado na perspectiva de Zabala (1998), Dolz e Schneuwly (2004) e Cabral (2017), além da perspectiva de Gonçalves (2020), Ambrozi, (2017) e Silva (2017). Na elaboração da Sequência Didática foram abordados três conceitos iniciais da Análise Combinatória, a saber: o Princípio Fundamental da contagem, a operação fatorial e a operação permutação. A pesquisa é de caráter qualitativo, na qual a Sequência Didática, organizada em 3 blocos cada um com 5 atividades, foi aplicada em uma turma de 30 alunos da 2ª série do ensino médio em uma escola estadual de Belém. Os resultados apontam que embora alguns conceitos não tenham sido assimilados pelos alunos, percebeu-se os discentes mais reflexivos e críticos mediante as questões. Concluiu-se que a Sequência Didática favorece a autonomia dos alunos e auxilia o professor na estruturação mais efetiva dos conteúdos.
Rastreio de déficit cognitivo e seu impacto na qualidade de vida de idosos residentes em instituição de longa permanência em Poços de Caldas-MG
Authors: Gurgel Antonio Carlos Gouvea do Amaral , Pereira Thais Nastrini , Alvisi Teresa Cristina 
Published: January 2025

O envelhecimento populacional é uma das mais significativas mudanças do século XXII. Estudos projetam que o número de idosos até 2050 chegará a 2,1 bilhões de pessoas no mundo. Esse cenário é repleto de múltiplos tipos de envelhecimento, podendo ser acompanhada por altos níveis de doenças crônicas quanto por saúde e bem-estar. O declínio cognitivo aparece como um dos acontecimentos fisiológicos do envelhecimento, no entanto são alterações que podem reduzir a funcionalidade e independência do indivíduo e, quando aliado à falta de assistência social e de políticas públicas para a população geriátrica, acaba por levar a institucionalização do idoso. O idoso institucionalizado, por sua vez, acaba por apresentar um expressivo nível de sedentarismo, carência afetiva e perda de autonomia, situação muitas vezes desencadeadora de depressão. Este projeto tem como finalidade realizar um levantamento de como o déficit cognitivo é capaz de impactar na qualidade de vida de idosos residentes em instituições de longa permanência no município de Poços de Caldas, MG. A pesquisa baseia-se na aplicação de questionários como Mini Exame do Estado Mental, Escala de Katz modificada por Likert, Escala de Depressão Geriátrica de Yesavage e WHOQOL-bref, para avaliação da cognição, capacidade de execução de atividades básicas de vida diária, depressão e a qualidade de vida dos participantes. Após a aplicação dos questionários, os dados obtidos foram submetidos à análise estatística visando comprovar as hipóteses levantadas.
ಶಿವಶರಣೆಯರ ವಚನಗಳಲ್ಲಿ ಪ್ರಾಣಿ ಪ್ರತಿಮೆ
Authors: ಶಂಕರ್ ಜ್ಯೋತಿ , ಆರ್ ಮಮತ ಬಿ 
Published: January 2025

ಜಗತ್ತಿನ ಸಾಂಸ್ಕೃತಿಕ ಇತಿಹಾಸವನ್ನು ಗಮನಿಸಿದರೆ ನಮ್ಮ ಕನ್ನಡ ನಾಡಿನ ಶರಣಸಂಸ್ಕೃತಿಯು ಮಹತ್ತರವಾದುದು. ೧೨ನೇ ಶತಮಾನದಲ್ಲಿ ಪ್ರವರ್ಧಮಾನಕ್ಕೆ ಬಂದ ಶರಣ ಸಂಸ್ಕೃತಿ ಹಾಗೂ ವಚನ ಸಾಹಿತ್ಯವು ಅಂದಿನ ಸಮಾಜದಲ್ಲಿ ನೆಲೆಯೂರಿದ್ದ ಅನೇಕ ಮೂಢನಂಬಿಕೆಗಳು, ಅಂಧಶ್ರದ್ಧೆಗಳು, ಅಂಧ ಆಚರಣೆಗಳು, ಅನಿಷ್ಟ ಪದ್ಧತಿಗಳ ವಿರುದ್ಧ ಧ್ವನಿ ಎತ್ತಲು ಸಹಾಯಕವಾಗಿದ್ದವು. ಬಸವಣ್ಣನವರಿಂದ ಸ್ಥಾಪಿತವಾದ ಅನುಭವ ಮಂಟಪದಲ್ಲಿ ಎಲ್ಲಾ ಶರಣರು ತನ್ನ ಅನುಭವ, ಚಿಂತನೆಗಳನ್ನು ಹಂಚಿಕೊಳ್ಳುತ್ತಿದ್ದರು. ಇದಕ್ಕಾಗಿ ಅವರು ಬಳಸಿಕೊಂಡ ಮಾಧ್ಯಮವೇ ವಚನಗಳು. ಶಿವಶರಣರು ಸಮಾಜದಲ್ಲಿ ಕಂಡ ಅನೇಕ ವಿಷಯಗಳನ್ನು ತಮ್ಮ ಮನದ ಅಂತರಾಳದಲ್ಲಿ ತುಡಿಯುತ್ತಿರುವ ಭಾವನೆಗಳನ್ನು ಸಮರ್ಪಕವಾಗಿ ವ್ಯಕ್ತಪಡಿಸಲು ಅನೇಕ ಪ್ರತಿಮೆಗಳನ್ನು ಬಳಸಿಕೊಂಡರು. ಅವುಗಳಲ್ಲಿ ಪ್ರಾಣಿ ಪ್ರತಿಮೆ ಕೂಡ ಒಂದಾಗಿದೆ. ಪ್ರಾಚೀನ ಕಾವ್ಯಗಳಲ್ಲೂ ಕೂಡ ಈ ಪ್ರಾಣಿ ಪ್ರತಿಮೆಗಳನ್ನು ಬಳಸಿಕೊಂಡು ಅನೇಕ ಕೃತಿಗಳು ಹೊರಬಂದಿವೆ. ಅವುಗಳಲ್ಲಿ ವಡ್ಡಾರಾಧನೆ, ಪಂಚತAತ್ರ, ಕರ್ಣಾಟಕ ಕಾದಂಬರಿ, ಇತ್ಯಾದಿ ಕೃತಿಗಳನ್ನು ಕಾಣಬಹುದಾಗಿದೆ. ಇದೇ ರೀತಿ ವಚನ ಸಾಹಿತ್ಯದಲ್ಲಿ ಶಿವಶರಣೆಯರು ಕೂಡ ತಮ್ಮ ವಚನಗಳಿಗೆ ವಿವಿಧ ಪ್ರಾಣಿಗಳನ್ನು ಪ್ರತಿಮೆಗಳನ್ನಾಗಿ ಬಳಸಿ ತಮ್ಮ ವಚನಗಳ ಸೌಂದರ್ಯವನ್ನು ಹೆಚ್ಚಿಸಿಕೊಂಡಿದ್ದಾರೆ. ಪ್ರಾಣಿಪ್ರತಿಮೆಗಳನ್ನು ಬಳಸಿಕೊಳ್ಳುವಿಕೆಯ ಮೂಲಕ ತಮ್ಮ ವಚನಗಳಲ್ಲಿ ಅಡಕವಾಗಿರುವ ಮೌಲ್ಯಗಳನ್ನು ಸುಲಭವಾಗಿ ಜನಸಾಮಾನ್ಯರಿಗೆ ಅರ್ಥೈಸಲು ಪ್ರಯತ್ನಿಸಿದ್ದಾರೆ. ಶಿವಶರಣೆಯರು ಪ್ರತಿಮೆಗಳನ್ನು ಉಪಮೆ, ರೂಪಕ, ಸಂಕೇತಗಳನ್ನಾಗಿ ಬಳಸಿ ತಮ್ಮ ವಚನಗಳ ಅರ್ಥಕ್ಕೆ ಒಂದು ನೆಲೆಗಟ್ಟನ್ನು ಕಟ್ಟಿ ಕೊಟ್ಟಿದ್ದಾರೆ. ಅಕ್ಕಮಹಾದೇವಿ, ಅಕ್ಕಮ್ಮ, ಅಮುಗೆ ರಾಯಮ್ಮ, ಹಡಪದ ಲಿಂಗಮ್ಮ, ನೀಲಮ್ಮ ಮುಂತಾದವರು ವಿವಿಧ ಪ್ರಾಣಿಗಳನ್ನು ತಮ್ಮ ವಚನಗಳ ಪ್ರತಿಮೆಗಳನ್ನಾಗಿ ಬಳಸಿದ್ದಾರೆ. ಈ ಪ್ರತಿಮೆಗಳು ಪ್ರಾಚೀನ ಕಾವ್ಯಗಳ ಸೌಂದರ್ಯವನ್ನು ಹೆಚ್ಚಿಸುವಂತೆ ವಚನಗಳನ್ನು ಕೂಡ ಸುಂದರವಾಗಿ ಅರ್ಥಪೂರ್ಣಗೊಳಿಸಲು ಸಹಕಾರಿಯಾಗಿವೆ.
Comparison of Dexamethasone with Prednisolone in Treatment of Acute Asthma
Authors: Fayyaz Madiha , Shahzad Haider  , Sidra Shafiq  , Sajid Nazir  , Kiran Israr Shah  , Haroon Rashid  
Published: January 2025

OBJECTIVE:
The objective of this study was to compare the efficacy of single dose oral dexamethasone with single dose oral prednisolone in the treatment of acute asthma exacerbation
MATERIALS AND METHODS
This study was conducted in the in the Department of Paediatrics,Hameed Latif Teaching Hospital Lahore from March 2023 to November 2023. Through a randomized controlled trial Study Design, a total of 160 children under 12 years of age were randomly allocated in two groups, children in group A were subjected to oral dexamethasone and in group B oral prednisolone was given. All children were followed up till 10th day after discharge to determine the efficacy of treatment in terms of relapse
RESULTS
The mean age of the infants in group A was 7.53 + 2.23 years while in group B it was 8.1 + 2.3 years (p value 0.107). Off the whole sample, we had 65% (n=52) males in group A and 55% (n=44) in group B, female gender was found in 35% (n=28) in group A while 45% in group B (n=36) with p value of 0.197. Efficacy in terms of relapse for group A was 85% while that of group B was 70%, (p value of 0.023).
CONCLUSION
The dexamethasone is more effective than prednisolone in the treatment of acute asthma exacerbation below 12 years of age, however, more randomized controlled trials especially in various combinations with bronchodilators in the management of acute asthma are required.
KEY WORDS
Acute Asthma, dexamethasone, steroid, prednisolone, , relapse
A novel measurement method to evaluate relationship between threshold voltage and polarization for understanding memory operation of ferroelectric field-effect transistors
Authors: Cho Seong-Kun , Toprasertpong Kasidit , Takenaka Mitsuru , Takagi Shinichi 
Published: January 2025

Abstract
Ferroelectric field-effect transistors (FeFETs) are attracting attention for next-generation non-volatile memory due to their compatibility with CMOS processes and excellent memory properties. However, understanding the complex interaction between ferroelectric polarization (P), trapped charges, and threshold voltage (V
TH) remains challenging. In this study, we propose a novel measurement method to separate the contribution of P to V
TH from that of trapped charges. Applying this method to Hf0.5Zr0.5O2-based FeFETs, we compare the V
TH–P relationship between a device with a SiO2 interlayer (IL) and that with an Al2O3/SiO2 IL. Our results provide direct evidence that the memory window is not solely determined by polarization but is significantly affected by electron trapping, which is strongly modulated by the properties of the interface. This underscores the effectiveness of the novel measurement method in characterizing simultaneously both polarization and charge trapping, making it a valuable tool for optimizing FeFET memory performance.