bluuebunny/crossref_metadata_2025_split huggingface dataset:
METTL1 mediated tRNA m 7 G modification promotes leukaemogenesis of AML via tRNA regulated translational control
Authors: Pan Zhao , Lin Xia , Dan Chen , Huanping Guo , Yinying Xu , Bingbing Yan , Xiao Wu , Wei Xu , Yuxia Li , Yunfang Zhang , Xi Zhang 
Published: August 2023

Abstract
Background
RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m7G) modification and its modifiers METTL1/WDR4 have been confirmed an oncogene role in multiple cancers. However, the functions and molecular mechanisms of METTL1/WDR4 in Acute Myeloid Leukemia (AML) remain to be determined.
Methods
METTL1/WDR4 expression levels were quantified using qRT-PCR, western blot analysis on AML clinical samples, and bioinformatics analysis on publicly available AML datasets. CCK-8 assays and cell count assays were performed to determine cell proliferation. Flow cytometry assays were conducted to assess cell cycle and apoptosis rates. Multiple techniques were used for mechanism studies in vitro assays, such as northern blotting, liquid chromatography-coupled mass spectrometry (LC-MS), tRNA stability analysis, transcriptome sequencing, small RNA sequencing, and protein synthesis measurements.
Results
METTL1/WDR4 are significantly elevated in AML patients and associated with poor prognosis. METTL1 depletion resulted in reduced cell proliferation and increased apoptosis in AML cells. Mechanically, METTL1 depletion leads to significant decrease of m7G modification abundance on tRNA, which further destabilizes tRNAs and facilitates the biogenesis of tsRNAs in AML cells. In addition, profiling of nascent proteins revealed that METTL1 depletion and transfection of total tRNA that isolated from METTL1 knockdown AML cells decreased global translation efficiency in AML cells.
Conclusions
Taken together, our study demonstrates the important role of METTL1/WDR4 in AML leukeamogenesis, which provides a promising target candidate for AML therapy.
Thermal conductivity of an epoxy resin enhanced with a polythiophene/graphene complex and aluminum nitride
Authors: Maruyama Tatsuo , Tominaga Yudai , Kado Junko , Morita Kenta , Moriwaki Tomoko , Kusamoto Yoshi , Yoshitomi Tomohiro , Mori Atsunori , Nishino Takashi 
Published: August 2023

Abstract
Thermal management plays an important role in electronic devices as the power density of electronic devices increases year by year. A polymer-composite with thermal conductivity is one of rational approaches for heat dissipation in electronic devices. We prepared epoxy resin-based composite films filled with a polythiophene [poly(3-hexylthiophene-2,5-diyl)]/graphene complex and aluminum nitride (AlN). Electrical resistance measurements indicate that the prepared epoxy films exhibited insulating properties. The composite films were characterized by electron microscopic observation, thermogravimetric analysis and thermal conductivity measurements. The addition of a small quantity of P3HT/graphene complex (< 1 wt%) increased the out-of-plane and in-plane thermal conductivities of the epoxy resin. The addition of AlN also increased the thermal conductivities, but required ≤ 40 wt% to obtain a thermal conductivity comparable with that of a 0.9 wt% P3HT/graphene complex. The present study suggested the high potential of P3HT/graphene complexes as fillers for improving the thermal conductivity of epoxy resins without affecting their insulating properties.
Magnetic and geochemical properties of Zagreb city area soils
Authors: Frančišković-Bilinski Stanislav , Peco Josip , Sakan Sanja , Đorđević Dragana , Inđić Dejan 
Published: August 2023

Abstract
The study was performed to get the first insight of distribution of the low field volume magnetic susceptibility (MS) throughout the Zagreb city area, based on in-situ field measurements on 125 locations. 25 most interesting locations were selected for soil sampling and geochemical content was determined using ICP-OES method. A geostatistical approach was applied on MS and geochemical results. Median value of 0.245 x 10− 3 SI units, obtained by in-situ measurements is proposed to be used as relevant average value of MS in Zagreb area. Mean concentrations of heavy metals measured in Zagreb soils are following: Pb (36.82 µg/g), Zn (87.77 µg/g), Cu (30.84 µg/g), Cd (0.66 µg/g), Cr (29.04), Co (11.89) and Ni (28.40). Those concentrations are relatively low in comparison with Croatian legislation and with Europe and world average. Boxplot analysis showed that 45% of studied elements do not show any anomaly (Al, Ca, Cu, Fe, K, Li, Mg, Ni and Pb) and most of them have regular normal distribution. The rest of other elements mostly show only one weak anomaly. Boxplot analysis confirmed element anomalies are located at the same sampling points where MS anomalies are located. Statistical correlations between MS in-situ measurements and analyzed elements are following: Cd (0.52), Co (0.54), Fe (0.35), Mn (0.74), Na (0.45), Pb (0.48), Sb (0.63) and Zn (0.75). In-situ MS measurements proved to be an efficient tool for initial screening of a large area in terms of elevated heavy elements concentrations, enabling cheap and fast assessment of state of environment.
Optimizing the edible film production from red pitaya peel powder, konjac glucomannan and kappa carrageenan
Authors: Putri Widya Dwi Rukmi , Rahma Rizka Aulia , Wardana Ata Aditya , Wijayanti Zahratul Hasanah , Nur Mokhamad , Mubarok Ahmad Zaki 
Published: August 2023

Abstract
Red pitaya, one of Indonesia's most abundantly produced horticultural products, offers a sustainable solution for reducing waste by utilizing its peel in the production of an edible film. This research aimed to develop an edible film from red pitaya peel (RPP) flour and Kappa carrageenan (Carr) with the optimal physical and mechanical properties. Konjac (K) was added to improve the brittleness and compactness of the film specimens. This study employed a central composite design (CCD) with two variables, RPP and Carr, with proportions ranging from 0.4% − 1.1% (w/v) and 0.29% − 1.71% (w/v), respectively. The optimized proportions of 0.50% (w/v) RPP and 1.28% (w/v) K-Carr resulted in the production of edible film with a tensile strength (TS) value of 7.75 MPa, elongation of 103%, thickness (T) of 99.8 µm, color L (72.5), a* (13.9), b* (0.5), opacity (O) of 4.56 mm− 1, water solubility (WS) of 81%, and water absorption capacity (WAC) of 863%.
Efficient Ring Signature for Cross-chain Data Sharing in Blockchain-enabled Cold-chain Logistics System
Authors: Zhang Yang , Tang Yu , Li Chaoyang , Zhang Hua 
Published: August 2023

Abstract
Blockchain-enabled cold-chain logistics system (BCCLS) has well solved the centralized problem in traditional systems. However, along with that different logistics entities establish their own distributed blockchain ledger, which brings new “data island” and privacy leakage problems for BCCLS. In this paper, a transaction ring signing model with a multi-chain fusion mechanism has been introduced first which helps to achieve secure cross-chain data sharing. Meanwhile, a ring signature (RS) scheme is proposed with lattice assumption, which can protect the user privacy and cross-chain transactions. The lattice hard problem improves the anti-quantum security of the transaction ring signing model. Then, the security proof has been executed with random oracle model, and the results show that this RS scheme can get anonymity under full key exposure and unforgeability under insider attack. The efficiency comparison and performance evaluation show the efficiency and practical of the proposed multi-chain fusion model and RS scheme.
On non-principal arithmetical numberings and families
Authors: Faizrahmanov Marat 
Published: August 2023

Abstract
The paper studies \(\Sigma^0_n\) -computable families ( \(n\geqslant 2\) ) and their numberings. It is proved that any non-trivial $\Sigma^0_n$-computable family has a complete with respect to any of its elements $\Sigma^0_n$-computable non-principal numbering. It is established that if a $\Sigma^0_n$-computable family is not principal, then any of its $\Sigma^0_n$-computable numberings has a minimal cover and, if the family is infinite, is incomparable with one of its minimal $\Sigma^0_n$-computable numberings. It is also shown that for any $\Sigma^0_n$-computable numbering \(\nu\) of a $\Sigma^0_n$-computable non-principal family there exists its $\Sigma^0_n$-computable numbering that is incomparable with $\nu$. If a non-trivial $\Sigma^0_n$-computable family contains the least and greatest elements under inclusion,then for any of its $\Sigma^0_n$-computable non-principal non-least numberings $\nu$ there exists a $\Sigma^0_n$-computable numbering of the family incomparable with $\nu$. In particular, this is true for the family of all $\Sigma^0_n$-sets and for the families consisting of two inclusion-comparable $\Sigma^0_n$-sets (semilattices of the $\Sigma^0_n$-computable numberings of such families are isomorphic to the semilattice of \(m\) -degrees of $\Sigma^0_n$-sets).
MSC Classification: 03D45
An often-overestimated ecological risk of copper in Chinese surface water: Bioavailable fraction determined by multiple linear regression of water quality parameters
Authors: Liao Wei , Zheng Yutao , Feng Chenglian , Zhong Wenjun , Zhu Ziwei , Xie Huiyu , Li Wenpan , Jin Xiaowei , Giesy John P. 
Published: August 2023

Abstract
Background
Risks of adverse ecological effects of copper (Cu) conditions of water quality parameters were not fully understood in China. Here, a multiple linear regression approach was employed to assess risks posed by Cu under various conditions of water quality. Results of the approach were compared to assessments in Chinese surface waters that did not consider water quality parameters that might affect availability of Cu.
Results
Under prevalent water quality conditions of hardness = 150.0 mg/L, pH = 7.8, and DOC = 3.0 mg/L, across China, the predicted no effect concentration for total, dissolved Cu was 9.71 µg/L. Based on results of the preliminary risk quotients method, 1.19% of sites were classified as “high risk”, only one sixth of the percentage of sites with “high risk” than the proportion predicted when not considering water quality parameters, which was 7.51%. Similar results were obtained by application of both the margin of safety and joint probability curve methods, both of which overestimated risks posed by Cu to aquatic organisms in China.
Conclusion
After correcting for bioavailability based on water quality parameters, based on both concentrations and frequencies, regions of China at greatest risk from adverse effects of Cu were the Hai River (Haihe), Huai Rivers (Huaihe) and Chao Lake. These findings provide a comprehensive method for a more accurate assessment of risks of adverse effects of Cu to aquatic life in surface waters.
Reported Safety of Hepatitis C Virus Direct-Acting Antivirals With Opioids: 2017 to 2021
Authors: Martinez Anthony , Khan Tipu , Dylla Douglas E. , Marcinak John , Collins Michelle , Saget Brad , Conway Brian 
Published: August 2023

Abstract
Introduction: Due to concerns over potential interactions between some hepatitis C direct-acting antivirals (DAAs) and opioids, we describe adverse event (AE) reports of concomitant use of opioids and DAAs.
Methods: AEs reported (July 28, 2017 to December 31, 2021) with the administration of the DAAs glecaprevir/pibrentasvir, sofosbuvir/velpatasvir, ledipasvir/sofosbuvir, sofosbuvir/velpatasvir/voxilaprevir, and elbasvir/grazoprevir as suspect products were downloaded from the US Food and Drug Administration AE Reporting System Public Dashboard. The number of AE reports containing opioids (fentanyl, hydrocodone, oxycodone) as co-suspect products/concomitant products were counted and summarized by severity, reporting country and whether an outcome of death was reported. Overdose AEs were counted irrespective of opioid use, and changes over time were assessed.
Results: In total 40 AEs were reported for DAAs and concomitant fentanyl use, 25 were in the USA, 14 resulted in death and 13 were considered serious; and 626 were reported with concomitant oxycodone/hydrocodone use, 596 were in the USA, 28 resulted in death an 296 were considered serious. There were 196 overdose AEs (32 deaths) declining from 2018 (N=56) to 2021 (N=29).
Conclusions: Treating people with HCV infection who use drugs is key to achieving HCV elimination. Low numbers of DAA AE reports with opioids may provide reassurance to prioritize HCV treatment in this population.
The Impact of Nasal Intubation on Feeding Outcomes in Neonates Requiring Cardiac Surgery: A Randomized Control Trial
Authors: Yildirim Melissa I. , Spaeder Michael C. , Castro Barbara A. , Chamberlain Rebecca , Fuzy Lisa , Howard Sarah , McNaull Peggy , Raphael Jacob , Sharma Ruchik , Vizzini Samantha , Wielar Amy , Frank Deborah U. 
Published: August 2023

Abstract
Neonates who require surgery for congenital heart disease (CHD) frequently have difficulty with oral feeds post-operatively and may require a feeding tube at hospital discharge. The purpose of this study was to determine the effect of oral or nasal intubation route on feeding method at hospital discharge. This was a non-blinded randomized control trial of 62 neonates who underwent surgery for CHD between 2018-2021. Infants in the nasal (37 patients) and oral (25 patients) groups were similar in terms of pre-operative risk factors for feeding difficulties including gestational age at birth (39 vs 39 weeks), birthweight (3530 vs 3100 grams), preoperative PO intake (92% vs 81%), and rate of preoperative intubation (28% vs 22%). Surgical risk factors were also similar including STAT category, shunt placement (32% vs 41%), cardiopulmonary bypass time (181 vs 177 minutes), and cross clamp time (111 vs 105 minutes). 96% of nasally intubated patients took full oral feeds by discharge as compared with 78% of orally intubated infants. Nasally intubated infants reached full oral feeds an average of three days earlier than their orally intubated peers. In this cohort of patients, nasally intubated infants reach oral feeds more quickly and are less likely to require supplemental tube feeding in comparison to orally intubated peers. Intubation route is a potential modifiable risk factor for oral aversion and appears safe in neonates. The study was approved by the University of Virginia Institutional Review Board for Health Sciences Research and was retrospectively registered on clinicaltrials.gov (NCT05378685) on May 18, 2022.
Are public sector workers in Ghana overpaid? Evidence from a Blinder-Oaxaca decomposition analysis.
Authors: Kaba Jeffrey 
Published: August 2023

Abstract
This paper employs the Blinder-Oaxaca decomposition method to estimate the private-public sector wage gap, investigating the public sector wage premium using an analytical sample of 876 wage workers. These workers were drawn from a nationally representative household dataset - the seventh round of the Ghana Living Standards Survey (GLSS 7) data. The results suggest that private sector workers, including those in the informal sector, earn lower wages than their counterparts possessing the same level of human capital in the public sector. However, the wage gap becomes statistically insignificant when observed among formal private sector workers and formal public sector wage workers. Returns to education in the public sector surpass those in the private sector, particularly for the secondary and tertiary graduates. These findings contribute to the ongoing debate about private-public wage differentials by introducing context-specific insights from Ghana, particularly when comparing the wages of formal private and public workers. Although the results challenge the common belief that private sector workers receive significantly less premium than public sector workers, this paper underscores the importance of formalizing the predominantly informal private sector as a policy measure to reduce the private-public wage gap.
Reassessment of inducible clarithromycin resistance inMycobacterium abscessus subsp. abscessus associated with diagnosis, treatment intervention, and sputum culture conversion in patients with Mycobacterium abscessus species pulmonary disease
Authors: Yoshida Shiomi , Tsuyuguchi Kazunari , Kobayashi Takehiko , Kurahara Yu , Shimatani Yasuaki , Arai Toru 
Published: August 2023

Abstract
This study assessed the characteristics of inducible clarithromycin resistance (IR) in Mycobacterium abscessus subsp. abscessus (MAB) associated with diagnosis, treatment intervention, and sputum culture conversion in patients with M. abscessus species pulmonary disease (MABS-PD). The proportion of patients with non-IR MAB T28 diagnosed with MABS-PDand treatment intervention rateswere lower than those of patients with IR or acquired resistant T28 (P < 0.05), whereas the sputum culture conversion rate was higher in patients with non-IR MAB T28 (P < 0.01). Among the 6 patients with C28, 4 (66.7%) of 5 patients with non-IR showed favourable microbiological outcomes.
Pencarian Jadwal Kuliah Pengganti
Authors: Wijana Katon , Oslan Yetli , Kristanto Harianto 
Published: August 2023

Jadwal kuliah telah ditetapkan sejak registrasi mahasiswa dilakukan, namun pada prakteknya jadwal tersebut ada kemungkinan gagal dilaksanakan oleh karena berbagai sebab, seperti misalnya dosen ada keperluan penting lain pada jadwal tersebut, hari libur nasional atau alasan lainnya. Sesuai dengan ketentuan peraturan akademik, banyaknya tatap muka perkuliahan sudah ditentukan yaitu 14 kali tatap muka (pertemuan), oleh sebab itu apabila ada tatap muka perkuliahan yang gagal dilaksanakan harus diganti dengan jadwal pengganti.
Pencarian jadwal pengganti kuliah tidak semata-mata memperhatikan jadwal dosen yang bersangkutan, namun juga harus memperhatikan ketersediaan ruang kuliah dan jadwal kuliah masing-masing mahasiswa supaya semua mahasiswa dipastikan dapat hadir (tidak sedang kuliah mata kuliah lain), sehingga jadwal pengganti dapat dilaksanakan tanpa mengganggu kegiatan mahasiswa.
Berbeda dengan penelitian sebelumnya, pada penelitian mengenai generator jadwal kuliah yang lalu dilakukan dengan teknik pencarian dan penyaringan, pada penelitian kali ini sistem akan menampilkan semua alternatif jadwal pengganti yang dapat dilaksanakan tanpa mengganggu jadwal dosen, jadwal mahasiswa maupin jadwal pemakaian ruangan dengan memanfaatkan query multiple table dengan relasi outer join.
Pencarian jadwal pengganti kuliah tidak semata-mata memperhatikan jadwal dosen yang bersangkutan, namun juga harus memperhatikan ketersediaan ruang kuliah dan jadwal kuliah masing-masing mahasiswa supaya semua mahasiswa dipastikan dapat hadir (tidak sedang kuliah mata kuliah lain), sehingga jadwal pengganti dapat dilaksanakan tanpa mengganggu kegiatan mahasiswa.
Berbeda dengan penelitian sebelumnya, pada penelitian mengenai generator jadwal kuliah yang lalu dilakukan dengan teknik pencarian dan penyaringan, pada penelitian kali ini sistem akan menampilkan semua alternatif jadwal pengganti yang dapat dilaksanakan tanpa mengganggu jadwal dosen, jadwal mahasiswa maupin jadwal pemakaian ruangan dengan memanfaatkan query multiple table dengan relasi outer join.
Keywords : Jadwal pengganti, alternatif jadwal, outter join
Analisis Kandungan Zat Gizi, Fenol, Flavonoid, Fitat, dan Tanin pada Sorgum (Sorgum bicolor (L.) Moench)
Authors: Avif Adnan Nur , Dewi Aptika Oktaviana Trisna 
Published: August 2023

This research studied the nutrition, phenols, flavonoids, phytates, and tannins of kawali and bioguma sorghum. The samples were obtained from marketplaces harvested in East Nusa Tenggara. Analysis of nutrients in sorghum includes tests for water content (gravimetry), ash (ashing), fat (soxhlet), crude fiber (enzymatic), and protein (kjeldahl). The water content, protein, fat, ash, and crude fiber content in the Kawali variety was relatively higher than in the Bioguma variety. Still, the carbohydrate content (by difference) was lower, namely 72.92% and 77.47% for the Bioguma variety. Phytate content (403.95 vs. 105.59) mg/100g, phenolics (1519.88 vs. 591.76) mg/100g, tannins (611.50 vs. 155.35) mg/100g, and flavonoids (42.45 vs. 10.52) mg/100g in kawali sorghum are almost four times higher than the bioguma variety. Two varieties of sorghum have different appearances and nutritional contents. The Kawali variety of sorghum has higher phenol, flavonoid, tannin, and phytate content than the Bioguma variety.Tujuan penelitian ini adalah menganalisis kandungan zat gizi, fenol, flavonoid, fitat, dan tanin dari sorgum jenis kawali dan bioguma. Sampel yang digunakan dalam penelitian ini diperoleh dari lokapasar yang dipanen di Nusa Tenggara Timur. Analisis zat gizi dalam sorgum meliputi uji kadar air (gravimetri), abu (pengabuan), lemak (soxhlet), serat kasar (enzimatis), dan protein (kjeldahl). Analisis komponen non gizi meliputi fitat, fenolik, tanin, dan flavonoid dengan metode spektrofotometri. Hasil penelitian menunjukkan bahwa kandungan air, protein, lemak, abu, dan serat kasar dalam varietas kawali relatif lebih tinggi dibandingkan dengan varietas bioguma. Adapun kadar karbohidrat (by difference) lebih rendah yaitu sebesar 72,92% dan 77,47% untuk varietas Bioguma. Kadar senyawa fitat (403,95 vs 105,59) mg/100g, fenolik (1519,88 vs 591,76) mg/100g, tanin (611,50 vs 155,35) mg/100g dan flavonoid (42,45 vs 10,52) mg/100g dalam sorgum kawali lebih tinggi hampir empat kali lipat dibanding varietas bioguma. Kedua varietas sorgum tersebut memiliki penampilan dan kandungan zat gizi yang berbeda. Sorgum varietas kawali memiliki kandungan fenol, flavonoid, tanin, dan fitat yang lebih tinggi dibandingkan varietas bioguma.