bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic intra-arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma
Authors: Wang Nan , Xu Jingwen , Wang Gang , Cao Pikun , Ye Xin 
Published: January 2023

Objective:
To preliminarily evaluate the efficacy and safety of pancreatic intra-arterial infusion chemotherapy (PAIC) with nab-paclitaxel in patients with advanced pancreatic carcinoma.

Methods:
Fifteen patients with advanced pancreatic carcinoma received monthly, inpatient, 3-h, continuous PAIC of nab-paclitaxel at 180 mg/m2, combined with 60 mg oral tegafur gimeracil oteracil potassium capsule for 2 weeks. The therapeutic courses were repeated every 4 weeks. All patients had a preliminary diagnosis based on clinical symptoms, imaging data (computed tomography or magnetic resonance imaging or positron emission tomography/computed tomography), and tumor markers. The adverse effects, clinical benefit response (CBR), objective response rate (ORR), median progression free survival (mPFS), and median overall survival (mOS) were monitored.

Results:
Fifteen patients with advanced pancreatic carcinoma were enrolled in this study, including 10 male and 5 female patients. The mean age at the time of treatment was 66.3 years (53–84 years). A total of 49 cycles of PAIC (mean = 3.27 cycles/patient) were performed. The most common treatment-related toxicities were alopecia, diarrhea, and nausea/vomiting. No procedure-related complications were observed. The longest overall survival observed was 22 months and the maximum number of treatments for the same patient was six cycles. PAIC contributed a high rate (13/15 [86.67%]) and fast (10/15 [66.67%]) easement of pain, with apparent symptom relief within 24 h, especially local pain symptom. The pain anesis rate was 13 (86.67%). CBR was achieved in 13 (86.67%) patients (95%CI [59.54,98.34]). ORR was achieved in four (26.67%) patients (95%CI [7.79,55.10]). Disease Control Rate was achieved in 14 (93.33%) patients. The mPFS was 5.22 months (interquartile range [IQR], 4.27–7.85 months). The mOS was 8.97 months (IQR, 5.65–13.70 months).

Conclusions:
In this study, the dose of the chemotherapeutics and the schedule of the transcatheter pancreatic arterial chemotherapy perfusion were shown to be safe, well-tolerated, and effective for the relief of clinical symptoms and CBR. These advantages can quickly establish the treatment belief and improve patient quality of life. This regimen requires further investigation in patients with advanced pancreatic carcinoma.
Emergency Physicians' Awareness of Medico-Legal Case Management
Authors: Alabdulqader Shahad , Alabdulqader Rana , Madadin Mohammed , Kashif Haider , Al Jumaan Mohammed A. , Yousef Abdullah Abdulsalam , Menezes Ritesh G. 
Published: January 2023

Background:
Emergency department physicians often encounter medico-legal cases when patients initially present to the hospital, and thus there is a strong need for them to have robust medico-legal management and reporting knowledge.

Objective:
To assess the awareness of emergency department physicians of two major hospitals in the Eastern Province of Saudi Arabia in managing medico-legal cases.

Methods:
This descriptive cross-sectional survey-based study included all adult and pediatric emergency physicians working at King Fahd Hospital of the University and King Fahd Specialist Hospital, two major government hospitals in the Eastern Province of Saudi Arabia. The questionnaire included questions about demographic information, the workload in the emergency department, previous medico-legal training, and information about physicians' perspectives regarding medico-legal situations.

Results:
A total of 85 physicians completed the questionnaire, with most being Saudis (78.8%) and consultants (44.7%). Most participants (84.7%) immediately notified the police authority through the official procedure on suspicion of a case being criminal. However, only 28.2% of the participants were aware of how to complete the medico-legal report, and the majority (82.4%) had not received any specific training or attended specific courses in writing medico-legal reports. Most participants (91.8%) expressed the need for additional medico-legal case training programs, with continuous education (29.4%) being the preferred mode. In addition, 60% of the consultants were dissatisfied with the current medico-legal reporting and management workflow in their hospital. About half of the participants did not obtain photographs in medico-legal cases and did not know if their workplace provided a protocol for collecting evidentiary material such as clothes, swabs, bullets, remnants of foreign bodies, etc.

Conclusions:
The results of the present study indicate the necessity to consider periodical continuing medical education programs and workshops for emergency department physicians in the Eastern Province of Saudi Arabia to help them in appropriately handling medico-legal cases.
Detection of COVID-19 using rapid point-of-care chromatographic immunoassay-based test
Authors: Singh Shubhendu , Bisht Dakshina , Rawat Ashutosh , Bansal Jagriti , Jain Ritu 
Published: January 2023

Introduction:
Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents has made meeting the rising demand for incompetent. Therefore, numerous easy-to-use rapid antigen tests (RATs) based on lateral flow technology have been developed and are the need of the hour. This has a risen a crucial need for point-of-care devices for on-site detection. The objective of this study was to detect SARS-CoV-2 in suspected persons by rapid point-of-care (POC) chromatography immunoassay-based test.

Aim:
The present study was conducted during the initial pandemic where all suspected cases were subjected to rapid POC chromatography immunoassay-based test and evaluated the outbreaks of COVID-19.

Materials and Methods:
A cross-sectional study was conducted among 239 patients suspected of COVID-19. Nasal samples were collected for the rapid diagnostic test. The rapid chromatographic immunoassay test was performed immediately in all the patients.

Results:
Of the 239 sample that were tested by Rapid antigen detection test, 89 (37.2%) were positive and 150 (62.7%) were found negative. Maximum number of patients that were positive from 60-74 years of which male were 23 (25.8%) and female were 13 (14.6%) and minimum number of cases were from above 75 years in which male were 5 (5.6%) and female 2 (2.2%).

Conclusion:
The RAT showed an admirable specificity to rule in COVID-19 patients within the first 5 days of illness and had a reasonable sensitivity. Therefore, patients showing positive results need to immediately get treatment and those with negative tests should be reconfirmed by rRT-PCR as it is considered the gold standard for COVID-19 testing.
Peripheral defocus as it relates to myopia progression: A mini-review
Authors: Erdinest Nir , London Naomi , Lavy Itay , Berkow David , Landau David , Levinger Nadav , Morad Yair 
Published: January 2023

Abstract
Myopia is the most common refractive error in the world and has reached a pandemic level. The potential complications of progressive myopia have inspired researchers to attempt to understand the sources of myopia and axial elongation and to develop modalities to arrest progression. Considerable attention has been given over the past few years to the myopia risk factor known as hyperopic peripheral blur, which is the focus of this review. It will discuss the primary theories believed to be the cause of myopia and the parameters considered to contribute to and influence the effect of peripheral blur, such as the surface retinal area of blur or the depth of blur. The multitude of optical devices designed to provide peripheral myopic defocus will be mentioned, including bifocal and progressive addition ophthalmic lenses, peripheral defocus single-vision ophthalmic lenses, orthokeratology lenses, and bifocal or multifocal center distance soft lenses, as well as their effectivity as discussed in the literature to date.
Spatiotemporal gene targeting in the mouse corneal endothelium
Authors: Lee JeongGoo , Heur Martin 
Published: January 2023

PURPOSE:
The inducible Cre-ERT2 recombinase system allows for temporal control of gene targeting, and it is useful to studying adult function of genes that have critical developmental roles. The Zeb1flox/flox: UBC-CreERT2 mouse was generated to conditionally target Zeb1 to investigate its role in mesenchymal transition in the mouse corneal endothelium in vivo.

MATERIALS AND METHODS:
Hemizygous UBC-CreERT2 mice were crossed with homozygous mice harboring loxP-flanked Zeb1 alleles (Zeb1flox/flox) to generate the Zeb1flox/flox: UBC-CreERT2 mouse. 4-hydroxytamoxifen (4-OHT) exposure leads to excision of exon 6 of Zeb1, resulting in a loss function allele in the Zeb1flox/flox: UBC-CreERT2 mouse. Intracameral 4-OHT injection further isolates Zeb1 targeting to the anterior chamber. Mesenchymal transition and induction of Zeb1 expression in the corneal endothelium was achieved using FGF2 in ex vivo organ culture. Gene expression was analyzed by semi-quantitative reverse transcription-polymerase chain reaction and by immunoblotting in the mouse corneal endothelium in vivo.

RESULTS:
Following Cre-mediated targeting of Zeb1 by intracameral 4-OHT injection in Zeb1flox/flox: UBC-CreERT2 mice, FGF2 treatment in ex vivo organ culture resulted in abrogation of Zeb1 mRNA and protein expression in the corneal endothelium.

CONCLUSION:
The data show Zeb1, a critical mediator of fibrosis in corneal endothelial mesenchymal transition, can be targeted by intracameral injection of 4-OHT in the mouse corneal endothelium in vivo. These results suggest that genes with critical developmental roles can be targeted at a specific time in the corneal endothelium to study its role in adult disease using an inducible Cre-Lox strategy.
Antibacterial Activity and Bioautography of the Chloroform Fraction of Morel Berry (Physalis angulata L.) Root Against Staphylococcus epidermidis and Pseudomonas aeruginosa
Authors: Viogenta Pratika , Susanti Laila , Megasari Latifah 
Published: January 2023

The urgency of finding novel sources of active compounds to overcome infectious diseases is encouraged. Morel berry (Physalis angulata L.) is a traditional herbal plant that can be used as an antimicrobial because of its unique chemical content. This study aims to find compounds that have antibacterial activity from the chloroform fraction of morel berry roots. This study used the Kirby-Bauer method with concentrations of 20%, 40%, 60%, 80%, and 100% against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. Determination of antibacterial compounds and their functional groups was performed using thin-layer chromatography (TLC) technique and reagent spray test, TLC-Bioautography and Fourier transforms infrared (FTIR) studies. The chloroform fraction of morel berry showed a zone of inhibition with the highest diameter of 11.50 and 12.00 mm against S. epidermidis and P. aeruginosa, respectively. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and saponins in the chloroform fraction. The relative retention stain of 0.54 on the TLC plate inhibited the growth of the two tested bacteria and indicated the presence of functional groups O-H phenol, C-H aliphatic, C=O ester, C=C aromatic, C-OH alcohol, and C-H aromatic. This study found that tannins in the roots of morel berries could be used as a natural antibacterial agent to treat S. epidermidis and P. aeruginosa.
RYŪKYŪ ROUND LACQUERED BOX | CHROMATIC REINTEGRATION METHODOLOGY
Authors: Sarmento Débora , Cavaco Margarida , Borges de Sousa Maria da Conceição 
Published: January 2023

An exemplar from the Ryūkyū Islands (Japan), this red lacquer circular box dates from c.1590 and is part of the collection of the National Museum of Ancient Art (MNAA) - Lisbon, Portugal [1-2]. The conservation and restoration intervention carried out at the José de Figueiredo Laboratory (LJF), considering its state of conservation with a high risk of lacquer detachment and consequent loss of a large part of the decorative elements, allowed the study and definition of methodologies, including in the treatment of chromatic reintegration [3]. Its condition, the type of intervention, as well as its subsequent placement on display, motivated the reintegration method chooses and its application, which aimed to improve the reading and decorative understanding of the box. The use of extra-fine quality gouache in the mimetic reintegration executed ensured the necessary compatibility and stability with its constituent materials.
Retouching a Retouched Painting: Evaluation and re-treatment of historic retouchings in the conservation of a painting by Lavinia Fontana
Authors: Marcattili Letizia , Canavan Maria 
Published: January 2023

A major conservation and research project on The Visit of the Queen of Sheba to King Solomon by Lavinia Fontana was completed at the National Gallery of Ireland in Dublin in 2021. The painting, a large-scale oil on canvas (256 x 325 cm), was one of a number of pictures restored in the late 1960s by a team of conservators from the Istituto Centrale del Restauro in Rome, who came to Dublin during the establishment of the first conservation studio at the Gallery. The visiting restorers brought novel ideas and materials with them from the Istituto that would shape the Irish approach to conservation for decades to come. The prevailing ethos at the time in Italy was based on a minimal intervention approach with the use of novel, synthetic materials that had not yet been introduced to the collection of the National Gallery of Ireland. The painting, after treatment by the Istituto team, recorded material evidence of a particular moment in the development of conservation in Italy and Ireland. Large areas of historic loss and damage across the surface of the painting had been reintegrated by the Italian restorers with the application of retouchings in the tratteggio style, also known as rigatino, using a Paraloid-based medium. In some cases, portraits and other significant details in the image were fully reconstructed by the retouchings. Underlying instability required the removal of some of these retouchings during the most recent treatment, but others could be retained if desired. With the help of archival images and documentation, a decision-making model was developed to evaluate the quality and historic value of these retouchings and to determine which to preserve, which to modify and which to remove. Reduction of retouchings often necessitates replacement, and the partial preservation of the historic retouchings brought further factors to bear on the decision-making model for the chromatic reintegration of the painting. A return to the tratteggio technique was chosen for the larger instances of loss compensation in the treatment, albeit with a finer hatching so that the newer reintegration remains distinguishable from the historic one. This was complemented with a pointillist technique over textured fillings for smaller and shallower losses. Furthermore, where blistering and heat damage in the paint layers resulted in uneven topography, a third auxiliary technique was used. The desired texture was found when testing Paraloid-based gels on a mock-up and applied to bring continuity the surface texture in these areas of the painting. With this approach we intend to meet the conservation needs of the object, restore the legibility of the image and retain the evidence of the historic intervention of this founding team of Italian restorers at the National Gallery of Ireland.
With a little help of my friends. A hopeful educational methodology on retouching for conservation-restoration students on wooden sculpture.
Authors: Tonini Francesca 
Published: January 2023

Is it possible to mix and match the theoretical foundations of Cesare Brandi - internationally recognized - with the new theories of Muñoz Viñas for a new ethics of restoration, taking into account the suggestions of Paul Philippot, who was the first to deal with the restoration of wooden sculpture? For educational purposes in restoration schools, is not easy to cover all these aspects of retouching, but it is important to find a method that allows students to acquire a solid foundation, and then to deepen the different aspects of the question, hopefully simple but at the same time effective. The Author develops a proposal based on three basic cornerstones: 1. familiarity with the techniques of execution of the work of art and the materials of which it is composed (study of technical art history, and laboratory practice from painting to gilding); 2. study of the basic principles of the restoration theory; 3. practical experiments with the different techniques of pictorial integration (tratteggio, selezione cromatica, selezione effetto oro, dots, mimetic retouching), of the different retouching materials (watercolors, tempera, varnish colors, micaceous), and with protective coatings. In all situations the basic theoretical principles are: 1. recognizability: the pictorial restoration must always be easily recognizable (also using modern technologies); 2. reversibility, i.e. the retouching must be easily reversible without endangering the original work. Thus, the proposed methodology will be a useful tool to contribute and work on the wooden cultural heritage by including not only tangible aspects but also emotional, ideological and above all identity meanings.
Congenital lung malformations: can we avoid computed tomography? A five-year study
Authors: Carfagnini Filomena , Vivacqua Donatella , Baldazzi Michelangelo , Marcolin Laura , Picchi Stefano Giusto , Lassandro Giulia , Simonetti Igino , Trovato Piero , Giacobbe Giuliana , Corvino Antonio , Greco Laura 
Published: January 2023

PurposeCongenital lung malformations (CLMs) consist of a variety of pulmonary development disorders. In the CLM approach, computed tomography (CT) is considered the gold standard imaging technique due to the high-resolution for the lung parenchyma evaluation, the study of the vascular system after contrast injection, and the multiplanar reconstructions. In the paediatric population CT is considered too invasive due to ionizing radiation and the use of contrast agent. Therefore, the indications for the use of magnetic resonance imaging (MRI) are increasing. The aim of our study is to compare retrospectively MRI and CT in the evaluation of CLMs, to reduce or avoid the use of contrast-enhanced CT in the paediatric population.Material and methodsWe retrospectively evaluated 22 paediatric patients with prenatal diagnosis of CLMs. All the patients underwent postnatal MRI in the first 2 weeks of life (except for a patient) and pre-surgery contrast-enhanced CT. A total of 7 blinded radiologists divided into 3 different groups independently reviewed each MRI and CT examination. Sensitivity and specificity of radiologists with different years of experience on the field, as well as of MRI findings regarding every pathology, were evaluated using a ROC curve. The interobserver agreement regarding the MRI findings was also measured.ResultsAnalysing the ROC curves, we observed that MRI provided a satisfactory accuracy for diagnosing most congenital pulmonary diseases.ConclusionsOur study showed that MRI without contrast agent allows us to reach a CLM diagnosis in good agreement with contrast-enhanced CT, which is considered the gold standard imaging technique.
14-3-3η protein is associated with disease activity and osteoporosis in patients with rheumatoid arthritis
Authors: Adel Yasmin , Sadeq Yousra 
Published: January 2023

ObjectivesThis study was designed to explore the potential association of serum 14-3-3η protein level with disease activity and bone mineral density (BMD) in Egyptian patients with rheumatoid arthritis (RA). Patients were recruited from the outpatient clinic at Mansoura University Hospital.Material and methodsOne hundred eighty-eight patients with RA and 192 matched controls were enrolled. The rheumatoid arthritis activity parameters were evaluated in RA patients. Bone mineral density was measured. Serum levels of 14-3-3η protein and IL-6 were estimated for all participants by enzyme-linked immunosorbent assays (ELISA).ResultsRheumatoid arthritis patients had a significantly higher median serum 14-3-3η protein level compared to matched controls (p ≤ 0.05). Serum level of 14-3-3η protein was significantly correlated with DAS28–ESR (p ≤ 0.05) and serum IL-6 level (p ≤ 0.05). The rheumatoid arthritis-osteoporosis group had significantly higher serum 14-3-3η protein than the RA-osteopenia group and RA-control group. Similarly, the difference of the serum 14-3-3η protein between the RA-osteopenia group and the RA-control group was significant. In the linear regression analysis, the strongest factors that were associated with BMD in RA patients were the serum level of 14-3-3η protein (p ≤ 0.05), IL-6
(p ≤ 0.05) and DAS28–ESR (p ≤ 0.05).ConclusionsSerum level of 14-3-3η protein was significantly elevated in RA patients compared to controls and is significantly correlated with parameters of activity disease. The RA-osteoporosis group had significantly higher serum 14-3-3η protein than the RA-osteopenia group and RA-control group. Serum 14-3-3η protein can be a promising biomarker to reflect RA activity and predict presence of osteoporosis in RA patients.
Cardiovascular lesions in giant cell arteritis
Authors: Dzhus Marta , Mostbauer Halyna 
Published: January 2023

IntroductionGiant cell arteritis (GCA) is a systemic vasculitis that affects large vessels. Cardiovascular complications that develop with GCA have high morbidity and can be fatal. The aim of this work was to discuss epidemiology, clinical picture, etiopathology and risk of development of cardiovascular complications in GCA.Material and MethodsA literature review was performed for 2002 to 2021 using PubMed and Medline scientific search databases. The following keywords were used to search academic journal databases: “giant cell arteritis”, “heart attack”, “cardiovascular system”, “aortic aneurysm”, “coronary heart disease”, “aortic dissection”, “myocardium” and “stroke”. Articles written in languages, other than English, were excluded.ResultsThe analysis of studies showed an increased risk of an aneurysm, aortic dissection, coronary heart disease, cerebrovascular events, and peripheral artery disease in patients with GCA. This was not surprising as it has been shown that, cardiovascular complications worsens the prognosis in GCA. According to the results of observations and cited studies the most significant risk of cardiovascular complications was observed in the first year following the diagnosis of GCA.ConclusionsPatients with GCA have an increased risk of cardiovascular disease, but research data/findings are somewhat conflicting, and there is limited information/knowledge on how to treat the patients. Awareness of the risk of cardiovascular disease in GCA is essential, and monitoring these potentially fatal consequences is mandatory in patients with GCA. It is critical to be aware of the danger of cardiovascular illness in GCA patients and to keep track of these potentially deadly outcomes.