bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health of wild fish exposed to contaminants of emerging concern in freshwater ecosystems utilized by a Minnesota Tribal community
Authors: Deere Jessica R. , Jankowski Mark D. , Primus Alexander , Phelps Nicholas B. D. , Ferrey Mark , Borucinska Joanna , Chenaux-Ibrahim Yvette , Isaac Edmund J. , Singer Randall S. , Travis Dominic A. , Moore Seth , Wolf Tiffany M. 
Published: August 2023

Abstract
Fish serve as indicators of exposure to contaminants of emerging concern (CECs)—chemicals such as pharmaceuticals, hormones, and personal care products—which are often designed to impact vertebrates. To investigate fish health and CECs in situ, we evaluated the health of wild fish exposed to CECs in waterbodies across northeastern Minnesota with varying anthropogenic pressures and CEC exposures: waterbodies with no human development along their shorelines, those with development, and those directly receiving treated wastewater effluent. Then, we compared three approaches to evaluate the health of fish exposed to CECs in their natural environment: a refined fish health assessment index, a histopathological index, and high-throughput (ToxCast) in vitro assays. Lastly, we mapped adverse outcome pathways (AOPs) associated with identified ToxCast assays to determine potential impacts across levels of biological organization within the aquatic system. These approaches were applied to subsistence fish collected from the Grand Portage Indian Reservation and 1854 Ceded Territory in 2017 and 2019. Overall, 24 CECs were detected in fish tissues, with all but one of the sites having at least one detection. The combined implementation of these tools revealed that subsistence fish exposed to CECs had histological and macroscopic tissue and organ abnormalities, although a direct causal link could not be established. The health of fish in undeveloped sites was as poor, or sometimes poorer, than fish in developed and wastewater effluent-impacted sites based on gross and histologic tissue lesions. Adverse outcome pathways revealed potential hazardous pathways of individual CECs to fish. A better understanding of how the health of wild fish harvested for consumption is affected by CECs may help prioritize risk management research efforts and can ultimately be used to guide fishery management and public health decisions. Integr Environ Assess Manag 2024;20:846–863. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Mode‐Selective Vibrational‐Tunneling Dynamics in theN=2 Triad of the Hydrogen‐Bonded (HF)2Cluster
Authors: Hippler Michael , Oeltjen Lars , Quack Martin 
Published: August 2023

AbstractRovibrationally resolved spectra of theNj=22,Ka=0←1 transition and of theNj=23,Ka=0←0 andKa=1←0 transitions of the hydrogen‐bonded (HF)2have been measured in the near infrared range near 1.3 μm by cw‐diode laser cavity ring‐down spectroscopy in a pulsed supersonic slit jet expansion. The spectroscopic assignment and analysis provided an insight into the dynamics of these highly‐excited vibrational states, in particular concerning the predissociation of the hydrogen bond and the tunneling process of the hydrogen bond switching. Together with our previously analyzed spectra of theNj=21andNj=22components, the mode‐specific dynamics in all three components of this triad can now be compared. In theN=2 triad, the HF‐stretching vibration is excited by two quanta with similar excitation energy, but the quanta are distributed in three different ways, which has a distinct influence on the dynamics. The observed band centers and tunneling splittings are in agreement with our recent calculations on the (HF)2potential energy hypersurface SO‐3, resolving the long‐standing discussion about the symmetry ordering of polyad levels in this overtone region. The results are also discussed in relation to the general questions of non‐statistical reaction dynamics of polyatomic molecules and clusters and in relation to quasi‐adiabatic channel above barrier tunneling.
Molecular subtypes of endometrial cancer: Implications for adjuvant treatment strategies
Authors: Yang Ye , Wu Su Fang , Bao Wei 
Published: August 2023

AbstractBackgroundWhen determining adjuvant treatment for endometrial cancer, the decision typically relies on factors such as cancer stage, histologic grade, subtype, and a few histopathologic markers. The Cancer Genome Atlas revealed molecular subtyping of endometrial cancer, which can provide more accurate prognostic information and guide personalized treatment plans.ObjectiveTo summarize the expression and molecular basis of the main biomarkers of endometrial cancer.Search StrategyPubMed was searched from January 2000 to March 2023.Selection CriteriaStudies evaluating molecular subtypes of endometrial cancer and implications for adjuvant treatment strategies.Data Collection and AnalysisThree authors independently performed a comprehensive literature search, collected and extracted data, and assessed the methodological quality of the included studies.Main ResultsWe summarized the molecular subtyping of endometrial cancer, including mismatch repair deficient, high microsatellite instability, polymerase epsilon (POLE) exonuclease domain mutated, TP53 gene mutation, and non‐specific molecular spectrum. We also summarized planned and ongoing clinical trials and common therapy methods in endometrial cancer. POLE mutated endometrial cancer consistently exhibits favorable patient outcomes, regardless of adjuvant therapy. Genomic similarities between p53 abnormality endometrial cancer and high‐grade serous ovarian cancer suggested possible overlapping treatment strategies. High levels of immune checkpoint molecules, such as programmed cell death 1 and programmed cell death 1 ligand 1 can counterbalance mismatch repair deficient endometrial cancer immune phenotype. Hormonal treatment is an appealing option for high‐risk non‐specific molecular spectrum endometrial cancers, which are typically endometrioid and hormone receptor positive. Combining clinical and pathologic characteristics to guide treatment decisions for patients, including concurrent radiochemotherapy, chemotherapy, inhibitor therapy, endocrine therapy, and immunotherapy, might improve the management of endometrial cancer and provide more effective treatment options for patients.ConclusionsWe have characterized the molecular subtypes of endometrial cancer and discuss their value in terms of a patient‐tailored therapy in order to prevent significant under‐ or overtreatment.
T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
Authors: Hansen Aida S. , Jensen Lea S. , Gammelgaard Kristine R. , Ryttersgaard Kristoffer G. , Krapp Christian , Just Jesper , Jønsson Kasper L. , Jensen Pia B. , Boesen Thomas , Johannsen Mogens , Etzerodt Anders , Deleuran Bent W. , Jakobsen Martin R. 
Published: August 2023

AbstractA key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majority of patients applicable for such treatment still fail to respond. It has been suggested that high immunological activity in the tumour is essential for achieving effective response to immunotherapy, which therefore have led to exploration of strategies that triggers inflammatory pathways. Here activation of the stimulator of interferon genes (STING) signalling pathway has been considered an attractive target, as it is a potent trigger of pro‐inflammatory cytokines and types I and III interferons. However, immunotherapy combined with targeted STING agonists has not yielded sustained clinical remission in humans. This suggests a need for exploring novel adjuvants to improve the innate immunological efficacy. Here, we demonstrate that extracellular vesicles (EVs), derived from activated CD4+ T cells (T‐EVs), sensitizes macrophages to elevate STING activation, mediated by IFNγ carried on the T‐EVs. Our work support that T‐EVs can disrupt the immune suppressive environment in the tumour by reprogramming macrophages to a pro‐inflammatory phenotype, and priming them for a robust immune response towards STING activation.
A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Briese Thomas , Tokarz Rafal , Bateman Lucinda , Che Xiaoyu , Guo Cheng , Jain Komal , Kapoor Vishal , Levine Susan , Hornig Mady , Oleynik Alexandra , Quan Phenix‐Lan , Wong Wai H. , Williams Brent L. , Vernon Suzanne D. , Klimas Nancy G. , Peterson Daniel L. , Montoya Jose G. , Ian Lipkin Walter 
Published: August 2023

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%–2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high‐throughput sequencing. We found no consistent group‐specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
A multi‐analytical approach to unmask two Etruscan‐Corinthian fake vases: A contribution to the illicit trafficking of cultural goods
Authors: Privitera Antonella , Palermo Francesca , Ridolfi Stefano , Sodo Armida 
Published: August 2023

AbstractThis work addresses the authenticity issue of fake potteries circulating in the illicit art market, imitating ancient artefacts, by an interdisciplinary and a multi‐analytical approach. In faking manufacture, unscrupulous forgers use increasingly advanced skills to mimic ancient materials and technologies and to produce artificial ageing. Despite the phenomenon of archaeological objects' forgery is considered a crime and a source of illicit earnings, there are not enough works in the literature to support the difficult unmasking of archaeological fake objects. In this work, a pair of ointment vases mimicking the “Etruscan‐Corinthian” style, seized thanks to the police activity of the Carabinieri Headquarters for the Protection of Cultural Heritage (Comando Carabinieri Tutela Patrimonio Culturale, TPC) and studied within “Laboratorio del Falso” at Roma Tre University, are analysed from the archaeological viewpoint, and then scientific investigations are carried out to understand materials and techniques used by the forger. The aim of this work is to provide useful tools for the study of similar fake objects by reconstructing the forger recipe and in particular identifying errors he committed with respect to the original manufactures, invisible to the eye. The characterization of raw materials is carried out by combining X‐ray fluorescence spectroscopy (XRF) and micro‐Raman spectroscopy techniques, in order to determine the composition of surface decoration, encrustations and surface deposits. By this simple protocol, it was possible to consistently clarify the aspects characterizing the modus operandi of the forger, through the identification of anachronisms, that is, materials and techniques incompatible with the hypothesized ancient manufacture. In particular, modern pigments of synthetic origin are found in decorations, such as cobalt‐based black pigment and Mars red pigments with the addition of a polymer to enhance the adhesion to the vases' body.
Clinical evaluation of a new fractional ablative 2910 nm erbium laser on photodamaged skin: A pilot study
Authors: Selim Mona M. , Lowery Joseph A. , Maredia Hasina S. , Zelickson Brian D. 
Published: August 2023

AbstractObjectiveTo examine the efficacy and safety of a new fractional, ablative erbium:glass fiber (Er:glass) laser (2910 nm) at improving clinical signs of photodamaged skin.Materials and MethodsThirty‐seven healthy participants aged 38–75 years with photodamaged skin were enrolled into two treatment groups. Group A (n = 14) received up to four laser treatments with mild settings, and focal facial subunits were treated with deeper settings. Group B (n = 23) received a single treatment using deeper settings. Following treatment, pain scores and severity and duration of skin responses (erythema, edema, and pinpoint bleeding) were assessed. Primary outcome was the improvement in participant and investigator Global Aesthetic Improvement Scale (GAIS) at 3‐month follow‐up. Secondary outcomes were participant satisfaction with treatment and whether they would repeat treatment.ResultsThirty‐five participants completed the study (n = 1 lost to follow up in each group). Both groups had similar mean participant and investigator GAIS scores of 3/5 corresponding to “Improvement.” All but two patients (both from Group A) reported improvement, satisfaction with treatment, and would repeat treatment. Posttreatment skin responses were mild‐to‐moderate, lasting up to 5 days. There was no scarring or dyspigmentation.ConclusionThe 2910 nm Er:glass laser provided improvement in photoaging with high patient satisfaction.
Thermo‐Responsive Hydrogels Coupled with Photothermal Agents for Biomedical Applications
Authors: Qian Yafei , Lu Sha , Meng Jianqiang , Chen Wansong , Li Juan 
Published: August 2023

AbstractIntelligent hydrogels are materials with abilities to change their chemical nature or physical structure in response to external stimuli showing promising potential in multitudinous applications. Especially, photo‐thermo coupled responsive hydrogels that are prepared by encapsulating photothermal agents into thermo‐responsive hydrogel matrix exhibit more attractive advantages in biomedical applications owing to their spatiotemporal control and precise therapy. This work summarizes the latest progress of the photo‐thermo coupled responsive hydrogel in biomedical applications. Three major elements of the photo‐thermo coupled responsive hydrogel, i.e., thermo‐responsive hydrogel matrix, photothermal agents, and construction methods are introduced. Furthermore, the recent developments of these hydrogels for biomedical applications are described with some selected examples. Finally, the challenges and future perspectives for photo‐thermo coupled responsive hydrogels are outlined.
Precise Side Chain Engineering Enabling High‐Performance Wide‐Bandgap Polymer Donors
Authors: Yin Zhe , Hu Di , Ma Xueqing , Liu Wenlong , Zheng Xinming , Li Dawei , Lu Hao , Liu Yuqiang , Liu Yahui , Bo Zhishan 
Published: August 2023

AbstractA series of wide bandgap (WBG) conjugated polymers PTFBDT‐C, PTFBDT‐O and PTFBDT‐S are designed and synthesized with alkyl, alkoxy and thioalkyl side chains. By selecting benzodithiophene derivatives as the donor units and benzothiadiazole derivatives as the acceptor units, PTFBDT‐C, PTFBDT‐O and PTFBDT‐S are all of wide optical bandgaps. Furthermore, low bandgap small molecule L8‐BO‐4F is used as the acceptor to fabricate organic solar cells (OSCs). According to the results, PTFBDT‐C:L8‐BO‐4F blend film displays appropriate phase separation, high hole and electron mobilities, etc. Thus, the power conversion efficiency (PCE) of PTFBDT‐C:L8‐BO‐4F based OSCs is 14.02%, which is much higher than those of PTFBDT‐O:L8‐BO‐4F based (9.06%) and PTFBDT‐S:L8‐BO‐4F based ones (10.45%). These results show that the side chain engineering is an effective strategy to improve photovoltaic performance of wide bandgap polymers.
A theoretical and practical framework based on plasticity theory for the drained behavior of single and multiple shallow footings
Authors: Barari Amin , Zhou Junyu , Bo Ibsen Lars , Nazem Majid , Nielsen Kent 
Published: August 2023

AbstractWith the shift of the offshore wind energy sector to deeper waters, demand for the development of more complex foundation solutions, particularly suction bucket – supported tripod/tetrapod and jacket foundations, has increased. This paper is divided into two main sections. The first part comprises a comprehensive review of the performance of circular surface and shallow foundations under combined loading (VHM), and how it can principally be understood in a theoretical framework of plasticity theory. Examination of the considered data suggested that the general assumption of over‐estimated non‐association degree with constant failure surface parameters and increasing vertical load may require further investigation. This may be attributed to the complex interplay of multiple properties such as stress level, soil strength profile and foundation geometry. The existing data in the literature were also used to provide practical guidance for a successful implementation of the elasto‐plastic constitutive relationships in offshore foundation design. In second part of the paper, the suitability of the non‐associated plasticity formulation for a baseline multi‐pod system in H‐M load space was investigated using three‐dimensional (3D) finite element (FE) analyses and not verified. Furthermore, the failure envelopes and hardening law for caissons with different embedment ratios differed from those recommended in the literature were established. Parametric studies of multi‐caisson foundations revealed that the failure mechanism of multi‐bucket foundations under horizontal loading depended greatly on the bucket spacing. The horizontal bearing capacities increased with the bucket spacing until they reached a threshold. Meanwhile, analyses of the multi‐bucket foundation under moment loading confirmed the occurrence of a push‐pull failure mechanism.
Synergistic effect of compatibilized nanoclay/polyethylene fibers on the impact strength of epoxy‐glass fiber nanocomposites
Authors: Shelly Daksh , Nanda Tarun , Mehta Rajeev 
Published: August 2023

AbstractEpoxy‐based glass fiber nanocomposites (EGFCs) have good static mechanical properties but lack in impact strength. Addition of thermoplastic fillers to EGFCs enhanced the impact strength but with lowered static properties. To overcome this issue, compatibilized polyethylene (PE) fibers and silanized clay platelets were reinforced in the EGFCs. The unique properties of PE fibers such as good toughness, high strength, resistance to chemicals, and light‐weight made them an ideal choice for this purpose. EGFCs were processed through vacuum‐assisted resin infusion molding (VARIM) technique and resulted in significant improvements in an impact strength. Compatibilization of nanoclay/PE fibers was confirmed using FTIR and SEM‐EDS analysis. Nanoclay morphology in EGFCs was determined using XRD and TEM analysis. Reinforcement of maleic anhydride grafted PE fibers and silanized nanoclay in EGFCs significantly increased the impact strength by160% over the reference EGFC (without nanoclay/PE fibers). FE‐SEM micrographs showed improved interfacial interaction among various constituents of EGFCs resulting in superior mechanical performance. The newly developed EGFCs have myriad applications in various industries, namely, automotive (bumpers, frames for racing bicycles etc.), marine (hulls, decks, etc.), aviation (radome, stabilizers, etc.), and sports (archery bows, vault poles, etc.).Highlights
Multi‐scale filler‐reinforced EGFCs fabricated through VARIM process.
Compatibilized reinforcement significantly improved impact strength.
Silanization of nanoclay validated with FTIR & morphology with XRD/TEM technique.
SEM‐EDS and FTIR confirmed successful compatibilization of PE fibers.
SEM showed improved interfacial interaction among various constituents of EGFCs.
Mechanical properties of acrylate matrix composite reinforced with manganese‐aluminum layered double hydroxide
Authors: Alazreg Asma , Vuksanović Marija M. , Egelja Adela , Mladenović Ivana O. , Radovanović Željko , Petrović Miloš , Marinković Aleksandar , Heinemann Radmila Jančić 
Published: August 2023

AbstractAcrylate polymers are used in several applications such as dentistry, medicine, and industry. The modification of their properties using the reinforcement is of key importance for the possible applications. Layered double hydroxides are materials that are easily synthesized by several techniques giving the possibility to modulate the chemical composition and morphology of the reinforcement and they consist of a divalent and a trivalent anion hydroxide and the layers can be exfoliated and thus provide a material interesting for composite reinforcement. In this paper, Mn was used as a divalent and Al as a trivalent cation. The obtained particles were used as reinforcement for the preparation of composites in 1, 3, and 5 wt% quantities and prepared samples were compared to the matrix consisting of PMMA. Physical mechanical properties of the sample having the best mechanical properties (with 3 wt% of MnAl‐LDH filers) exhibited 6.38% modulus of elasticity, 27% hardness, and 10% tensile strength improved values compared to the clear PMMA matrix. Toughness was lowered in this sort of composite compared to the pure matrix.Highlights
MnAl‐LDH‐PMMA composites improved modulus, strength, hardness
Loss of toughness is tolerable for 3 wt% reinforcement
Viscoelastic properties are improved for composites compared to matrix
Trends in use of proton pump inhibitors among adults in the United States from 1999 to 2018
Authors: Bergin Emily , Zylberberg Haley M. , Lebwohl Benjamin , Freedberg Daniel E. 
Published: August 2023

AbstractPurposeProton pump inhibitors (PPIs) are among the most commonly used drugs in the United States (U.S.). We aimed to determine the trends in use of PPIs among adults in the U.S. from 1999 through 2018, hypothesizing the trend would follow an inverted U‐shaped curve, with a decline in recent years due to safety concerns.MethodsTemporal trends in use of prescription PPIs were assessed using the 1999–2018 National Health and Nutrition Examination Survey (NHANES), a nationally representative cross‐sectional survey of non‐institutionalized U.S. civilians. Use of PPIs was defined as any use during the month preceding the survey. Descriptive statistics were produced and trends in PPI use were examined, stratified by sex, age, race, body mass index (BMI), and poverty level.ResultsUse of prescription PPIs increased from 4.1% of U.S. adults in 1999–2000 to 8.6% in 2017–2018 (p for trend <0.01). All of the increase was observed during the first half of the study period (4.6% increase from 1999 to 2008 vs. 0.5% decrease from 2009 to 2018) and almost all of it was among those aged 55 or more (8.6% increase among those aged ≥ 55 compared to 1.2% increase among those aged < 55, p for interaction based on age <0.01).ConclusionsUse of prescription PPIs increased from 1999 to 2008 and then plateaued through 2018. This rise was driven by increased usage among older NHANES respondents.