bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced representations of assumed fields for Hu–Washizu solid-shell element
Authors: Wisniewski K. , Turska E. 
Published: March 2023

AbstractMixed eight-node (hexahedron) solid-shell elements based on the standard or partial version of the three-field Hu–Washizu (HW) functionals are developed for Green strain. Three reduced representations of the assumed stress/strain fields are selected. They improve effectiveness, yet retaining good accuracy and convergence properties. At the outset, the standard HW functional and the assumed stress/strain representations of the 3D solid element B8-15P (Weissman in Int J Numer Methods Eng 39:2337–2361, 1996) are used to derive a solid-shell element with 51 parameters. To eliminate locking, the ANS method is applied to the thickness strain (Betsch and Stein in Commun Numer Methods Eng 11:899–909, 1995) and to the transverse shear strain (Dvorkin and Bathe in Eng Comput 1:77–88, 1984). It is a correct element which, however, yields too large displacements for coarse meshes and trapezoidal through-thickness shapes. To improve the above formulation, the $$\zeta $$
ζ
-independent reduced representations of the assumed stress/ strain fields are selected and the transformations to Cartesian components are modified. The thickness strain is enhanced by the EAS method. The element with 35 parameters is derived from the standard/enhanced HW functional, but, to further reduce the assumed fields, partial/enhanced HW functionals are constructed from the 3D potential energy by applying the Lagrange multiplier method only to selected strain components. In the element with 27 parameters, this is applied to the constant in-plane strain and to the transverse shear strain while in the element with 19 parameters, to the constant in-plane strain only.Two other modifications are implemented to enhance the behavior of these elements: (A) the skew coordinates are used in the reduced representations of the in-plane stress/strain (Wisniewski and Turska in Int J Numer Methods Eng 90:506–536, 2012), and (B) the Residual Bending Flexibility correction of the transverse shear stiffness (MacNeal in Comput Struct 8(2):175–183, 1978) is adapted. Finally, the performance of the proposed solid-shell HW elements is demonstrated on several linear and non-linear examples for the linear elastic material and the hyper-elastic material. The proposed elements are compared to each other and to the best existing elements of this class.
Haptoglobin genotype and its relation to asymptomatic cerebral small-vessel disease in type 1 diabetes
Authors: Eriksson M. I. , Syreeni A. , Sandholm N. , Dahlström E. H. , Gordin D. , Tatlisumak T. , Putaala J. , Groop Per-Henrik , Martola J. , Thorn L. M. ,   The FinnDiane Study Group
Published: March 2023

Abstract
Aim
Cerebral small-vessel disease (SVD) is prevalent in type 1 diabetes and has been associated with the haptoglobin variant allele Hp1. Contrarily, the Hp2-allele has been linked to cardiovascular disease and the role of haptoglobin-genotype in asymptomatic SVD is unknown. We, therefore, aimed to evaluate the alleles’ association with SVD.

Methods
This cross-sectional study included 179 neurologically asymptomatic adults with type 1 diabetes (women 53%, mean age 39 ± 7 years, diabetes duration 23 ± 10 years, HbA1c 8.1 ± 3.2% [65 ± 12 mmol/mol]). Examinations included genotyping (genotypes Hp1-1, Hp2-1, Hp2-2) by polymerase chain reaction, clinical investigation, and magnetic resonance brain images assessed for SVD manifestations (white matter hyperintensities, cerebral microbleeds, and lacunar infarcts).

Results
SVD prevalence was 34.6%. Haptoglobin genotype frequencies were 15.6% (Hp1-1), 43.6% (Hp1-2), and 40.8% (Hp2-2). Only diastolic blood pressure differed between the genotypes Hp1-1, Hp1-2, and Hp2-2 (81 [74–83], 75 [70–80], and 75 [72–81] mmHg, p = 0.019). Haptoglobin genotype frequencies by presence versus absence of SVD were 16.1%; 46.8%; 37.1% versus 15.4%; 41.9%; 42.7% (p = 0.758). Minor allele frequencies were 39.5% versus 36.3% (p = 0.553). Hp1 homozygotes and Hp2 carriers displayed equal proportions of SVD (35.7% vs 34.4%, p > 0.999) and SVD manifestations (white matter hyperintensities 14.3% vs 17.9%, p = 0.790; microbleeds 25.0% vs 21.9%, p = 0.904; lacunar infarcts 0% vs 3.6%, p > 0.999). Hp1-1 was not associated with SVD (OR 1.19, 95% CI 0.46–2.94, p = 0.712) when adjusting for age, blood pressure, and diabetic retinopathy.

Conclusions
Although the SVD prevalence was high, we detected no significant association between SVD and haptoglobin-genotype.
Advancement in Design and Failure Analysis of Aluminium Foam-filled Honeycomb Crash Absorbers
Authors: Valente G. , Ghasemnejad H. , Srimanosaowapak S. , Watson J. W. 
Published: March 2023

AbstractHoneycomb structures are frequently used as energy absorption devices in the automotive and aerospace industry. Many studies have been conducted to optimise these structures and improve crashworthiness behaviour. This paper attempts to improve the crashworthiness behaviour of a honeycomb crash box by filling the cells with open-cell aluminium foams. Experimental tests were conducted to develop the honeycomb and aluminium foam material model and, also, to validate the finite element model by experimental data. The finite element model was developed in ABAQUS, and different variables were parameterised to aim a quick implementation. The empty aluminium honeycomb crash box is used as a term of comparison with the foam-filled ones. Foam-filling the crash box allows the control of the densification zone for different impact energies using open-cell aluminium foam, which shows the main novelty of this research. In the end, the optimised structure is presented concerning the optimum number of foam-filled cells and, also, to the aluminium foam’s density that best fits this application.
The impact of patient skin colour on diagnostic ability and confidence of medical students
Authors: Dodd Rebecca V. , Rafi Damir , Stackhouse Ashlyn A. , Brown Celia A. , Westacott Rachel J. , Meeran Karim , Hughes Elizabeth , Wilkinson Paul , Gurnell Mark , Swales Catherine , Sam Amir H. 
Published: March 2023

AbstractPrevious literature has explored unconscious racial biases in clinical education and medicine, finding that people with darker skin tones can be underrepresented in learning resources and managed differently in a clinical setting. This study aimed to examine whether patient skin colour can affect the diagnostic ability and confidence of medical students, and their cognitive reasoning processes. We presented students with 12 different clinical presentations on both white skin (WS) and non-white skin (NWS). A think aloud (TA) study was conducted to explore students’ cognitive reasoning processes (n = 8). An online quiz was also conducted where students submitted a diagnosis and confidence level for each clinical presentation (n = 185). In the TA interviews, students used similar levels of information gathering and analytical reasoning for each skin type but appeared to display increased uncertainty and reduced non-analytical reasoning methods for the NWS images compared to the WS images. In the online quiz, students were significantly more likely to accurately diagnose five of the 12 clinical presentations (shingles, cellulitis, Lyme disease, eczema and meningococcal disease) on WS compared to NWS (p < 0.01). With regards to students’ confidence, they were significantly more confident diagnosing eight of the 12 clinical presentations (shingles, cellulitis, Lyme disease, eczema, meningococcal disease, urticaria, chickenpox and Kawasaki disease) on WS when compared to NWS (p < 0.01). These findings highlight the need to improve teaching resources to include a greater diversity of skin colours exhibiting clinical signs, to improve students’ knowledge and confidence, and ultimately, to avoid patients being misdiagnosed due to the colour of their skin.
Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception
Authors: Bychkovsky Brittany L. , Lo Min-Tzu , Yussuf Amal , Horton Carrie , Hemyari Parichehr , LaDuca Holly , Garber Judy E. , Scheib Rochelle , Rana Huma Q. 
Published: March 2023

Abstract
Purpose
Herein, we report the frequency and distribution of germline pathogenic variants (PVs) among females with breast cancer (BC) and at least one other non-BC who underwent multi-gene panel testing (MGPT). Among females with PVs diagnosed first with BC or ovarian cancer (OC), we sought to enumerate the frequency of subsequent PV-associated cancers.

Methods
Females with BC and cancer of ≥ 1 other site (multiple primary cancers, MPC) who underwent MGPT through Ambry Genetics from March 2012 to December 2016 were included if they had testing of at least 21 genes of interest (ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, and TP53). Phenotypic data were abstracted from test requisition forms and clinical notes.

Results
Of 6,617 evaluable patients, most were White (70.8%) and median age at first cancer, second cancer, and MGPT was 49 (interquartile range [IQR]: 18), 59 (IQR: 16), and 63 (IQR: 16) years, respectively. PVs were found among 14.1% (932/6617) of the overall cohort and in 16.4% (440/2687) of females who were diagnosed first with BC. Among those, 55.2% (243/440) had an actionable PV associated with a subsequent cancer diagnosis including 150 OCs. Of the 2443 females with breast and ovarian cancer, few (n = 97, 9.5%) were diagnosed first with OC, limiting our analysis.

Conclusions
Females with MPC, including BC, have a high frequency of germline PVs (14.1%). These data delineate the opportunities for intercepting subsequent cancers associated with genetic risk among females diagnosed first with BC.
Adherence to endocrine therapy in early breast cancer in relation to Cytochrome P450 2D6 genotype: a comparison between pharmacy dispensation data and medical records
Authors: Thorén Linda , Margolin Sara , Eliasson Erik , Bergh Jonas , Lindh Jonatan D. 
Published: March 2023

Abstract
Purpose
Suboptimal adherence to adjuvant endocrine treatment (AET) is an important clinical concern. A correlation between CYP2D6 activity and tamoxifen discontinuation has been described. The main aim of this study was to investigate the consistency between pharmacy dispensation data and medical records on adherence to AET.

Methods
Adherence was calculated for patients with at least 4.5 years of follow up and was defined as Medical Possession Rate ≥ 80%. Subgroup analyses were performed based on menopausal status, recurrence risk and CYP2D6 activity.

Results
In 86% of the 1235 included patients the consistency between the two sources of information was within 80–125%. Poor consistency, < 80%, was most frequent in the premenopausal/ high-risk group and CYP2D6 Poor Metabolizers (PMs). Among 899 patients with at least 4.5 years follow up, 72% were adherent to tamoxifen based on pharmacy dispensation data, compared with 77% as reported by medical records. When including patients who switched to aromatase inhibitors after tamoxifen, adherence increased to 82% and 88%, respectively. Adherence did not differ by menopausal status or risk for recurrence. CYP2D6 PMs had poorer adherence (54%) to tamoxifen compared to patients with the highest CYP2D6 activity (83%).

Conclusions
There was a good consistency between medical records and pharmacy dispensing data on the use of AET. Adherence to AET was adequate, especially when including switch to aromatase inhibitors. Surprisingly, CYP2D6 PMs had low adherence to tamoxifen, despite a likely reduced risk of side effects according to previous data.
Vulnerability of diked marsh ecosystems under climate change
Authors: Dorau Kristof , Mansfeldt Tim 
Published: March 2023

AbstractDiked marsh soils are natural laboratories where soil-forming processes take place over a short period of time, such as the aeration of previously water-saturated soil environments along with desalinization. These manmade ecosystems are threatened by climate change in multiple ways. Since long-term data to evaluate the vulnerability of these settings is scarce, we merged hydrological (water table, WT; electrical conductivity, EC; sea level rise), pedological (redox potential, EH; air-filled porosity, AFP), and meteorological variables (evapotranspiration, ET0; climatic water balance, CWB), and discussed the holistic relationship between these under future climate scenarios. Our multifactorial data identified ET0as the strongest driver of WT development with a causal dependency on AFP and subsequently on EH. Within 11 years of intense monitoring, we encountered an extension of the soils’ aeration windows (EH > 300 mV) due to an enhanced seasonal WT component; i.e., the difference between winter and summer WT positions increased. This process has an impact on capillary rise from groundwaters and EC patterns due to increased seasonal variations. Desalinization stabilized two decades after diking, and the present EC does not indicate any saltwater intrusion to these near-coastal settings at present. However, sea level rise and a reduced CWB in the future will foster capillary rise from potentially salt-enriched groundwaters into the topsoils of these highly productive ecosystems. These mechanisms need to be evaluated to account for climate change–driven impacts on coastal-diked marsh soils. Indeed, a holistic view of pedological, meteorological, and hydrological variables is urgently needed.
Detecting the asymptomatic colonization of apple branches by Neonectria ditissima, causing European canker of apple
Authors: Harteveld D. O. C. , Goedhart P. W. , Houwers I. , Köhl J. , de Jong P. F. , Wenneker M. 
Published: March 2023

Abstract
European canker is one of the most devastating fungal diseases of apple in most temperate regions. The causal agent, Neonectria ditissima, infects trees through wounds in the bark forming cankers that girdle the stem and eventually cause tree death. Timely protection of the trees is challenged by stagnation of symptom expression after infections for a long period of time. The objective of this research is to use a novel TaqMan PCR assay to detect and quantify N. ditissima during the asymptomatic colonization of apple wood. Pruning wounds on branches of the cultivars Elstar and Gala were inoculated with N. ditissima and wood discs were sampled at 2–6, 10–14, and 30–34 mm distance from the inoculation site after 3 hours, 2 weeks, 4 weeks and 8 weeks for the detection and quantification of the pathogen. The TaqMan PCR assay detected N. ditissima in 51% of the inoculated apple tree samples. This was more sensitive than the culturing method detecting N. ditissima in 11% of the samples. An accumulation of N. ditissima DNA up to 34 mm distance from the inoculation site was observed without development of visible symptoms. To our knowledge this is the first time colonization of N. ditissima was detected and quantified in the absence of symptoms of European canker. The implications of this research are discussed.
Titanium alloys developed on the basis of the addition of cheap strong eutectoid β-stabilisers
Authors: Bolzoni L. , Paul M. , Yang F. , Alshammari Y. 
Published: March 2023

AbstractHistorically, titanium alloys have been developed disregarding the addition of eutectoid β-stabilisers as they generally lead to the formation of brittle intermetallic phases upon solidification of the alloy. However, such phenomenon can be prevented using powder metallurgy. Thus, this study considered the concurrent addition of cheap strong eutectoid β-stabilisers, namely Mn and Fe, for the development of new ternary Ti–Mn–Fe alloys, reducing the intrinsic cost of Ti alloys. It is found that the progressive addition of Mn and Fe in equal concentration enhances the densification of Ti during sintering, leading to lower amount of residual porosity, the transformation of the microstructure from purely lamellar to metastable, and the associated refinement of the microstructural features (grains and lamellae), as well as the stabilisation of a greater amount of β phase, and the formation of the metastable α″ phase. Such microstructural changes result in the strengthening (higher yield and ultimate tensile strength and hardness) and embrittlement of the alloy by changing the fundamental strain hardening mechanism of the ternary Ti–Mn–Fe alloys.
Thriving on Strengths: Effects of a Strengths Intervention for Younger and Older Teachers
Authors: Tobias Valesca Y. , van Woerkom Marianne , Meyers Maria Christina , Runhaar Piety , Bakker Arnold B. 
Published: March 2023

AbstractThe teaching profession is characterized by high demands and teachers who thrive are better able to navigate their demanding context than teachers who survive. Based on theories on strengths use we propose that strengths interventions which help teachers to identify, use, and develop their strengths can enhance their thriving (vitality and learning) which enables them to perform better. In addition, based on the socioemotional selective theory we propose that strengths interventions are especially beneficial for older teachers because it fits their goals and skills. We conducted a quasi-experimental study, in which 152 teachers and their team leaders participated in a strengths intervention. Longitudinal survey data indicated that the strengths intervention contributed to older teachers’ (≥ 46 years old) vitality, which in turn, contributed to their performance. No significant effects were found for younger teachers. We discuss the implications of our study for older teachers.
Determination of inorganic anions in uranium ore concentrate reference materials
Authors: Pagliano Enea , Keegan Elizabeth , Varga Zsolt , Nadeau Kenny , Meija Juris , Wong Henri , Vardanega Christopher , Wallenius Maria , Mayer Klaus , Cochrane Chris , El-Jaby Ali , Mester Zoltán 
Published: March 2023

AbstractThe determination of inorganic anions in uranium ore concentrates (UOCs) is useful to nuclear forensics for establishing the provenance of sample materials. In this collaborative study, quantitation of inorganic anions was carried out on three UOC reference materials from the National Research Council Canada: UCLO-1 (https://doi.org/10.4224/crm.2020.uclo-1), UCHI-1 (https://doi.org/10.4224/crm.2020.uchi-1), and UPER-1 (https://doi.org/10.4224/crm.2020.uper-1). The analytes were extracted into water and characterized by ion chromatography with combined standard uncertainties (uc) between 1.6 and 11%. The highest contributor to uc was homogeneity. Sulfate was the most abundant anion (2000–12,000 mg/kg SO42−). Other anions were in the 15–500 mg/kg range.
Spatial and temporal landslide distributions using global and open landslide databases
Authors: Gómez Derly , García Edwin F. , Aristizábal Edier 
Published: March 2023

AbstractLandslide databases are a potential tool for the analysis of landslide susceptibility, hazard, and risk. Additionally, the spatio-temporal distribution of landslides and their correlation with their triggering factors are inputs that facilitate the evaluation of landslide prediction models and the determination of thresholds necessary for early warning systems (EWS). This study presents an analysis of four widely known global databases—the International Disaster database (EM-DAT), the Disaster Inventory System (DesInventar), the Global Landslide Catalog (GLC), and the Global Fatal Landslide database (GFLD)—which contain relevant landslide information for different regions of the world. These databases were analysed and compared by means of the spatio-temporal distributions of their records. Subsequently, these databases were merged and depurated to obtain a more robust database, namely the Unified Global Landslide Database (UGLD), with 161 countries, 37,946 landslides, and 185,753 fatalities registered between 1903 and 2020. The merging process among the databases resulted in a small number of repeated landslides, indicating that the databases collect very different landslide information and complement each other. Finally, an update of the spatial and temporal analysis of landslides in the world was performed with the new database, in which patterns, trends, and the main triggers were presented and analysed. The results obtained from the analysis of the UGLD database show the American and Asian continents as the continents with the highest number of landslides and associated fatalities, showing a bimodal and unimodal annual temporal pattern, respectively. Regarding the most frequent triggers of landslides, rainfall, anthropogenic intervention, and earthquakes stand out.
Underwater VLC channel estimation based on Kalman filtering for direct current optical- and asymmetrically clipping optical- orthogonal frequency division multiplexing techniques
Authors: Shawky Eman , Aly Moustafa H. , El-Shimy Mohamed 
Published: March 2023

AbstractIn this paper, we suppose an underwater optical wireless communication (UOWC) system, where the communication utilizes visible light communication for its advantages as wide spectrum, high data rate and high accuracy. The novelty of this paper is focused on improving the channel estimation between transmitter and receiver, where using Kalman Filter (KF) for channel estimation in UOWCs achieves the best results as compared to other traditional channel estimation methods. The scenario of this paper is summarized in transmitting data from transmitter to receiver via underwater harbor and coastal channels. Two channel models are utilized: weighted double gamma functions (WDGF) and a combination of exponential and arbitrary power function (CEAPF). The modulation technique used is optical orthogonal frequency division multiplexing with two kinds: direct current optical orthogonal frequency division multiplexing (DCO-OFDM) and asymmetrically clipping optical orthogonal frequency division multiplexing (ACO-OFDM). Three different techniques are used for channel estimation: Least Square (LS), minimum mean square error (MMSE), and KF. The simulation results reveal that the ACO-OFDM modulation technique with CEAPF channel modeling using KF achieves the lowest bit error rate (BER) compared to other channel estimation methods. The improvement percentage at BER = 10−1 is 13.3% for ACO-OFDM over DCO-OFDM with CEAPF in coastal water and is is 9.3% for WDGF. This indicates that CEAPF performs about 4% better than WDGF for ACO-OFDM than DCO-OFDM in terms of channel estimation.