bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-Induced Liver Injury from Anti-Tuberculosis Treatment in a Case of TB Meningitis
Authors: ALakkad Ashraf , Sami Mahmoud , Abdalla Jehad Saleh , Tahir Nahla El 
Published: June 2023

This case study revolves around a 38-year-old male patient who arrived at the Emergency department complaining of decreased levels of consciousness, agitation, and disorientation. The case follows his admittance to the ICU, while a team of doctors worked on finding a possible diagnosis for his condition.
It was later in the course of his disease that it was found from his CSF(Cerebrospinal fluid) sample that he was suffering from tuberculous meningitis. The culture result revealed a strain of Mycobacterium Tuberculosis that was sensitive to all the major anti-tuberculous drugs. This was a favorable point for the prognosis of this patient. Once he was started on a regimen of selected anti-TB drugs, his symptoms improved to the point of successful discharge from the hospital.
However, a few days later, the patient again started experiencing symptoms that were serious enough to justify hospital admission. It was found that it was not any primary issue causing the symptoms this time, but rather the toxicity of the anti-tuberculous drugs. However, due to timely diagnosis, intervention, and management, his condition was managed effectively and he was discharged once again.
This case study aims to measure the importance of prescribing the most effective yet adequate treatment regimen for all patients, keeping in mind several overlooked yet highly important health-related factors that could either exacerbate or deteriorate pre-existing health concerns in a given patient. If the patient had been evaluated carefully for any underlying liver diseases or been given a short trial to see if he could withstand the high dose of anti-tuberculous drugs, he would not have faced such dreadful consequences, though they were managed quickly.
Keywords: Cerebrospinal fluid, Mycobacterium Tuberculosis, liver diseases, anti-tuberculous drugs.
Assessment and Authentication of Promea Therapeutic’s Indigenous Digital Hemoglobin Analyzer (Dr. Protech H+)
Authors: Sachan Anjali 
Published: June 2023

Haemoglobin estimation is an important screening test for patients. Despite many methods available, each method has some advantages and disadvantages. Hemoglobin estimation by digital Hemoglobin Meter proved to be a very reliable, sophisticated, appropriate and ideal especially for some particular setup like blood donation / premedical screening and also reliable in comparison to hematology analyzer. Materials and Methods: A study of 350 Single donor platelet donors to evaluate a Promea’s Digital Hemoglobin Analyzer (Dr. Protech H+) was done in a laboratory from November 2022 to December 2022.and data were compared to Sysmex KX 21 cell counter which is one of the most accurate methods for Haemoglobin estimation. Out of 350 donors 247 were male and 103 were female. Mean value of Promea’s Digital Hemoglobin Analyzer (Dr. Protech H+) (mean 14.0 g/dl) was slightly lower by 0.2 compared to reference (mean 14.2 g/dl) but not statistically significant. In comparison to cell counter Promea’s Digital Hemoglobin Analyzer (Dr. Protech H+) proved to be the cost effective with sensitivity and specificity more than 95%. which indicates high precision. Conclusion: Promea’s Digital Hemoglobin Analyzer (Dr. Protech H+) gives comparable results to cell counter and hence proved to be reliable, easy to operate and cost effective.
Keywords: Haemoglobin, DIGITAL Hemoglobin Meter, Promea’s Digital Hemoglobin Analyzer
Literature Review on the Therapeutic Potential of NAMPT in Brain Diseases
Authors: Olayemi Joel Oluwamurewa , Eneh Nebechukwu William , Ovabor Etinosa Bright , Arome Hauwa-Kulu Saidu , Mohammed Hajara Shitu 
Published: June 2023

Nicotinamide Phosphoribosyl transferase (NAMPT) is an important enzyme in the biosynthesis NAD+ and the byproduct nicotinamide mononucleotide (NMN) is also a vital intermediate in NAD+ synthesis. More importantly, the enzyme has been found to have therapeutic potential in the management and treatment of brain diseases such as stroke, depression, and cerebral ischemic injury. In this review, we looked critically at studies that have sought to explore the activities of NAMPT in the brain, the relevant pathways, the byproducts, and precursors of NAMPT with the hope to utilizing the knowledge gotten from the studies to project the possibility of utilizing the enzyme as a better way to treat brain diseases. The enzyme is projected to have a double-edged influence on cell processes and aging Likewise, it has neuroprotective advantages in neurons that express them. More scientific studies have shown that NAMPT is involved in the chain of activities involved in preventing depression. This review further elaborates on the therapeutic potentials of NAMPT, and also seeks to recommend further studies in this field to be carried out on a regular basis due to its promising potential.
Keywords: NAMPT; Brain; Therapeutic potential; Diseases; NAD; Cerebral ischemic injury, Stroke
Efficacy of Irsal-i-Alaq (Hirudotheraphy) in the Management of Venous Ulcer: A Case Report
Authors: Wani Khalid Rahim , Nayab Mohd , Ansari Abdul Nasir , Anwar Mohd 
Published: June 2023

Background: The most frequent and recurring type of leg ulcers seen in general practise is a venous ulcer (stasis ulcer). Its neglect has a considerable negative influence on quality of life, might result in gangrene, and may necessitate amputating the affected limb. The most serious and incapacitating complication of chronic venous insufficiency is venous ulcer. The conventional system of medicine offers limited clinical evidence for its effectiveness and usually needs amputation. Hence, it can be managed well by one of the Unani regimens, i.e., Irsal-e-Alaq (Hirudotherapy). Objective: The purpose of this case report is to provide insight into the effects of Irsal-e-Alaq (Hirudotherapy) in venous ulcer. Intervention: A 53-year-old male who has complaints of ulcer in left lower leg near lateral malleolus with swelling, pain, discharge and darkening of skin of left lower limb. Four leeches were applied once every 15 days for 45 days. Ulcer was assessed on 0th day, 15th day, 30th day and 45th day on the basis of area of the wound in a square centimetre, appearance of healthy granulation tissues, epithelization in percentage and depth of wound in centimetres, pain (VAS scoring), discharge, smell and number of wounds. Results: on the first day wound size was 4 cm long, 3 cm wide, 2 cm deep and the floor filled with dark granulation tissue with 0 % epithelization, discharge, pain and smell. On the 45th day ulcer was completely healed with 100% epithelization. Conclusion: Irsal-e-Alaq has been proven beneficial in treating venous ulcers and enhancing patients' quality of life. To determine the effectiveness of Irsal-e-Alaq in the management of venous ulcer, rigorous, controlled, randomised, blinded, and long-term follow-up studies on high sample sizes are required.
Keywords: Hirudotherapy, Unani Medicine, Leech Therapy, Varicose Ulcers
Synergistic Effects of Essential Oils and Antibiotics Against Some Bacterial Strains
Authors: Feudjieu Egoume Gaizirene , Kemegne Gislaine Aurelie , Tchinda Fossi Cedric , Tchamgoue Deutou Armelle , Moni Ndedi Esther Del Florence , Matchuenkam Gayap Sonia , Agbor Gabriel A. 
Published: June 2023

The emergence of antibiotics resistances become an alarming situation due to the resurgence of cases. Scientific community explore therapeutics alternatives, including essentials oils and their combination with antibiotics. The designed study aimed to evaluate the combined effects of essentials oils from Drypetes Gosswelleri, Echinops giganteus, Melaleuca leucadendron essentials oils and antibiotics against strains implicated in infectious deseases. The antibacterial effect of essentials oils and antibiotics (Ciprofloxacine and Ceftriaxone) was carried out against Pseudomonas aeruginosa, Klebsiella pnemoneae, Salmonella enteritidis, Staphylococcus aureus and Bacillus cereus strains using the microdilution method. The synergistic effects were studied by the isobologram method to conclude on the interaction type. The results revealed that the essential oils were active against all the tested bacteria. Drypetes Gosswelleri EO showed the strongest activity with MICs ranging from 1.46 μg/mL to 11.71 µg/mL, followed by Echinops giganteus essential oil with MICs ranging from 2.92 µg/mL to 23.43 µg/mL and Melaleuca leucadendron had the lowest activity with MICs ranging from 5.88µg/mL to 750µg/mL. The combinations realized between Drypetes Gosswelleri and Echinops giganteus EOs and with two antibiotics use to evaluate the interaction type agains Salmonella enteritidis and Staphylococcus aureus. MICs obtained with the combinations are lower than those obtained with the EOs and antibiotics tested individually. The isobolograms plotted inform about a synergistic effects of combinations made with Drypetes Gosswelleri, Echinops giganteus EOs, Ciprofloxacin and Ceftriaxone against S. enteritidis and S. aureus strains. Based on the results obtained, the combinations between EOs and the antibiotocs, represent an interesting therapeutic alternative.
Keywords: antibacterial, essential oil, combination, isobolograms, synergistics, Minimale Inhibitory Concentration, Minimale Bactericidal Concentration.
Comparative Effectiveness of Glimepiride versus Linagliptin as add-on to Metformin in Type-2-Diabetes Mellitus
Authors: Awofisayo Sunday Olajide , Akwaowoh Akpabio Elijah , Arhewoh Matthew Ikhuoria , Akpakpan Goodluck Sunday 
Published: June 2023

Background: In addition to lifestyle modifications, metformin is the recommended first-line pharmacotherapy for patients with type 2 diabetes mellitus (T2DM). The use of glimepiride or linagliptin as add-on to metformin (GM or LM) has been noticed on prescriptions in major pharmacies in Nigeria.
Aims: The aim of this study was to compare the efficacy of glimepiride or linagliptin as add-on to metformin in T2DM.
Methods: A preliminary case-crossover randomized experimental/observational study comprising 30 participants (i.e., 15 for each of the combination therapies) was designed and designated GM and LM groups, respectively. Baseline physiological and health-indicators of the participants were primarily observed followed by a practical/analytical drug efficacy measurement of postprandial blood glucose (PPBG) levels at 1, 2, 4, and 6 h once weekly for 2 weeks and thereafter crossover to the other regimen for another two weeks’ assessment.
Results: Baseline results were consistent across subgroup analyses in both treatment types. The statistical analysis demonstrated that LM achieved significant PPBG lowering potential compared to baseline blood glucose status (p<0.05). There was no significant difference in the observed physiological and biochemical indicators of organ system function for both treatments during the study. Treatment with LM was associated with reduced post-meal blood glucose compared with GM (p<0.05). Postprandial blood glucose change over measurement points were higher with LM (p<0.05).
Conclusion: Blood glucose control was better achieved with LM compared to GM. Propensity to hypoglycemia was higher with LM. More studies involving larger patient population in several centres are required to validate the outcome of these findings.
Keywords: Glimepiride, Linagliptin, Metformin, Fasting Blood Glucose, Postprandial blood glucose, Type 2 Diabetes Mellitus
Assay of Diphenhydramine HCl in Syrup by High Performance Liquid Chromatography
Authors: Sulistiyo Joko 
Published: June 2023

Cough is a natural response from the respiratory tract by increasing the clearance of secretions and particles from mucus, irritants, foreign particles, and microbes, so that it can act as a body defense. One way that can be done to relieve cough symptoms is to use symptomatic drugs. Diphenhydramine HCl is an antihistamine that belongs to the first generation H1 receptor antagonist (H1 blocker) group which has sedative and anti-allergic properties. Diphenhydramine HCl is used to treat sneeze, runny nose, watery eyes, itches, skin rashes, and other cold symptoms or other allergies. Diphenhydramine HCl is also used to treat motion sickness and to induce sleep. The purpose of this study was to determine the contents of diphenhydramine HCl syrup sold in the market. This test uses the High Performance Liquid Chromatography (HPLC) method with acetonitrile as a mobile phase; water; triethylamine (50;50;0.5). The results obtained the average content of Diphenhydramine HCl 102.5%. So it can be concluded that the cough medicine sample meets the requirements because the contents are not less than 90% and not more than 110% based on the Indonesian Pharmacopoeia Edition VI 2020.
Keywords: Cough, Diphenhydramine HCl, High Performance Liquid Chromatography (HPLC)
White rice with ghee does not increase blood sugar level in type 2 diabetes patients
Authors: Khartode Swati Suresh , Shinde Sushant , Jagtap Namdev 
Published: June 2023

Introduction: Type 2 diabetes in which India is the second largest globally, characterized by hyperglycemia resulting from defects in insulin action. Rice is the staple food of over half of the world’s population, having multiple Nutritional Benefits. Objective: To see the effect of white rice with ghee by cooking in an open vessel on blood sugar level in diabetic patients.
Materials and Methods: Experimental study with Clinical Trial performed at Vishwaraj Hospital Pune, to correct Blood Sugar Level in type 2 diabetes patients by Nutritional Intervention of White Rice which was cooked in an open vessel with Ghee after Institutional Ethics Committee approval and registered under Clinical Trial Registry of India -CTRI/2022/05/042533. All 103 enrolled participants were provided written information of ‘Method of Rice preparation’. During intervention, telephonic follow up had taken every 15th day, till 90 days. After 90 days of intervention, all patients were asked to repeat HBA1C level to compare their previous HBA1C which was done before enrollment.
Results: After 3 months of intervention, 86.41% participants had decreased HBA1C level, 13.59% participants had increased HBA1C. Statistical analysis done by Paired t Test which compares the means of two measurements of HBA1C taken from same individual i.e. paired observations, purpose of test is to determine whether there is statistical evidence that the mean difference between paired observations is significantly different from zero.
Conclusion: This study concluded that white rice prepared with ghee in an open vessel does not increase blood sugar level in type 2 diabetes patients.
Keywords: “blood sugar level”, “Diabetes”, “ghee”, “hba1c level”, “type 2 diabetes”, “white rice”
Drug-Induced Hypersensitivity Reaction and Re-Introduction of Anti-Tubercular Drugs (ATT): A Case Report and Review of Literature
Authors: Gupta Gaurav , Das Aranya Kumar , Kirtana J , Baitha Upendra , Sinha Sanjeev 
Published: June 2023

Tuberculosis (TB) is a communicable disease caused by the bacillus Mycobacterium tuberculosis and is the leading cause of death by a single infectious agent overall. According to the WHO Global TB Report, India contributes to 26% of the global burden of TB. Currently, a four-drug regimen comprising Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol is approved for the treatment of drug-sensitive TB. The management of cutaneous adverse drug reactions to anti-tubercular drugs is akin to a double-edged sword, with discontinuation of ATT increasing the risk of developing disseminated and drug-resistant tuberculosis, and continuation leading to persistence or exacerbation of the adverse drug reaction (ADR). The risk of developing an ADR to anti-tubercular therapy (ATT) varies from 8 to 85% in various studies [10]. The prevalence of rashes associated with ATT shows that the maculopapular rash (42.5%) is the most frequently observed type, followed by urticarial, lichenoid, DRESS, AGEP, and exfoliative dermatitis (17). The drugs associated with Cutaneous ADRs from the lowest to the highest risk are Isoniazid, Rifampicin, Pyrazinamide, Ethionamide, Cycloserine, Ethambutol, Para-aminosalicylic acid (PAS), and Streptomycin (25). We present a case and approach to the re-introduction of first-line anti-tubercular drugs after hypersensitivity with fixed-dose combinations.
Keywords: Tuberculosis, Mycobacterium tuberculosis, adverse drug reaction, anti-tubercular therapy
Evaluation of the effects of Momordica charantia on tibial defect injury in rats
Authors: KASIRGA Zeynettin , TUNCER Mehmet Cudi , Gezer Rabia , DEVECİ Engin , Aşır Fırat 
Published: June 2023

We aimed to examine the histological and immunohistochemical effects of Momordica charantia on bone repair, which provides positive regulation such as blood sugar, blood pressure, antilipidemic, anticarcinogenic, antibacterial, antioxidant, anti-inflammatory, wound healing, and tissue regeneration in rats with tibial bone defect. Momordica charantia (MC) (commonly called bitter melon; Goya; bitter apple; bitter gourd; bitter squash; balsam-pear; with many more names listed below) is a tropical and subtropical vine of the family Cucurbitaceae, widely grown in Asia, Africa, and the Caribbean for its edible fruit. Its many varieties differ substantially in the shape and bitterness of the fruit. In this study, 32 male Sprague Dawley rats, 12 weeks old and weighing 250-300gr, were used. 8 rats in each group randomly, 1st group control, 2nd group defect (Sham), 3rd group defect + MC group (14 days), 4th group defect + MC group (28 days) separated into the group. In this experimental study, 600 mg/kg/day MC (bitter melon) extract was mixed into the drinking water of groups 3 and 4 and administered to rats by oral tube. One 6 mm diameter cylindrical defects were created in the body of the right tibia bone. No action was taken in Group 1. In Group 2, only tibial defect was made. For 14 days in group 3 and 28 days in group 4, 600 mg/kg/day MC extract was mixed with drinking water and given by oral gavage. Elevated Malondialdehyde (MDA) levels and Myeloperoxidase (MPO) decreased. In groups 3 and 4, osteoblastic activity and osteocyte development increased, while osteopontin and osteonectin expression were found to be positive, while osteoclastic activity decreased compared to the sham group. It is a good antioxidant in the groups where MC is applied. It has been observed that it can have a positive effect on bone repair.
Keywords: Momordica charantia; Tibial defect; Fracture healing; Bone repair; Antioxidant
Pengaruh E-Service Quality dan Promosi Terhadap Keputusan Pembelian Konsumen Generasi Milenial Pada Layanan Traveloka
Authors: Durado Jenny Erysca , Febianti Febianti , Nova Muhamad 
Published: June 2023

Traveloka salah satu Online Travel Agent di Asia Tenggara. Penelitian ini bertujuan mengetahui kualitas pelayanan dan promosi belum terbukti dapat meningkatkan keputusan pembelian konsumen. Dengan teknik pengumpulan data menggunakan kuesioner dengan jenis penelitian kuantitatif. Sampel yang digunakan dalam penelitian ini sejumlah 100 pengguna. Analisis data, yaitu statistik deskriptif, analisis regresi linier berganda, dan uji hipotesis. Hasil penelitian menunjukkan bahwa E-Service Quality dan Promosi memiliki pengaruh secara simultan terhadap Keputusan Pembelian Konsumen Generasi Milenial yang berpengaruh dan signifikan terhadap keputusan pembelian sehingga konsumen generasi milenial yang sudah pernah menggunakan layanan Traveloka maupun pengguna yang baru menggunakan layanan Traveloka merasa nyaman dengan E-Service Quality yang dimiliki oleh layanan Traveloka saat melakukan transaksi pembelian. Jumlah konsumen yang melakukan transaksi pada layanan Traveloka akan semakin meningkat jika Promosi dari layanan Traveloka dapat dikembangkan sehingga dapat menggapai cakupan konsumen dari berbagai kalangan secara luas.

Traveloka is one of the Online Travel Agents in Southeast Asia. This study aims to determine the quality of service and promotion has not been proven to improve consumer purchasing decisions. With data collection techniques using a questionnaire with the type of quantitative research. The sample used in this study was 100 users. Data analysis, namely descriptive statistics, multiple linear regression analysis, and hypothesis testing. The results show that E-Service Quality and Promotion have a simultaneous influence on Millennial Generation Consumer Purchase Decisions which have a significant and influential effect on purchasing decisions so that millennial generation consumers who have used Traveloka services and users who are new to Traveloka services feel comfortable with E-Service. Quality owned by Traveloka services when making purchase transactions. The number of consumers who make transactions on Traveloka services will increase if Promotions from Traveloka services can be developed so that they can reach a broad range of consumers from various circles.
Pengaruh Kompensasi dan Pengawasan Terhadap Produktivitas Kerja Karyawan di Hotel
Authors: Lestari Ni Made Ratih Ayu Dian , Sudjana I Made , Supartini Ni Luh 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kompensasi dan pengawasan terhadap terhadap produktivitas kerja karyawan di Hotel Alila Seminyak secara parsial dan simultan. Penelitian ini menggunakan metode kuantitatif dengan mengolah data primer melalui kuisioner yang diberikan kepada karyawan di department Front Office, Housekeeping, Food and Beverage Dapartment, Human Resources, Sales and Marketing dan Engineering Department. Populasi dalam penelitian ini sebanyak 85 responden diambil keseluruhannya. Analisis data yang digunakan yaitu uji asumsi klasik (uji normalitas, uji linearitas, uji autokorelasi, uji multikolinearitas, uji heteroskedastisitas) dan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa secara simultan kompensasi dan pengawasan berpengaruh signifikan terhadap produktivitas kerja karyawan, dimana nilai uji F didapatkan dengan Fhitung = 1627,846 dan nilai signifikansi 0,000 < 0,05. Secara parsial kompensasi berpengaruh signifikan (0,000 < 0,05) terhadap produktivitas kerja karyawan dengan thitung = 45,147. Pengawasan berpengaruh signifikan terhadap produktivitas kerja karyawan dimana thitung = 34,320 dan nilai signifikan (0,000 < 0,05).

This study aims to determine the effect of compensation and supervision on the work productivity of employees at the Alila Seminyak Hotel partially and simultaneous. This study uses quantitative methods by processing primary data through a questionnaire given to employees in the Front Office, Housekeeping, Food and Beverage Department, Human Resources, Sales and Marketing and Engineering Department. The population in this study as many as 85 respondents were taken entirely. The data analysis used is the classic assumption test (normality test, linearity test, test autocorrelation, multicollinearity test, heteroscedasticity test) and linear regression analysis double. The research results show that simultaneously compensation and supervision significant effect on employee work productivity, where the value of the F test is obtained with Fcount = 1627.846 and a significance value of 0.000 <0.05. Partially compensated significant effect (0.000 <0.05) on employee work productivity with tcount = 45,147. Supervision has a significant effect on employee work productivity where tcount = 34.320 and significant value (0.000 <0.05).