bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanin‐Integrated Structural Color Hybrid Hydrogels for Wound Healing
Authors: Cao Xinyue , Sun Lingyu , Xu Dongyu , Miao Shuangshuang , Li Ning , Zhao Yuanjin 
Published: May 2023

AbstractHydrogel patches have outstanding values in wound treatment; challenges in this field are concentrated on developing functional and intelligent hydrogel patches with new antibacterial strategies for improving healing process. Herein, a novel melanin‐integrated structural color hybrid hydrogel patches for wound healing is presented. Such hybrid hydrogel patches are fabricated by infusing asiatic acid (AA)‐loaded low melting‐point agarose (AG) pregel into the melanin nanoparticles (MNPs)‐integrated fish gelatin inverse opal film. In this system, MNPs not only impart the hybrid hydrogels with properties of photothermal antibacterial and antioxidant, but also improve the visibility of structural colors by providing an inherent dark background. Besides, the photothermal effect of MNPs under near‐infrared irradiation can also trigger liquid transformation of AG component in hybrid patch, resulting in the controllable release of its loaded proangiogenic AA. Attracting, this drug release induced refractive index variations in the patch can be detected as visible structural color shifting, which can be used to monitor their delivery processes. Benefiting from these features, the hybrid hydrogel patches are demonstrated to achieve excellent therapeutic effects for in vivo wound treatment. Thus, it is believed that the proposed melanin‐integrated structural color hybrid hydrogels are valuable as multifunctional patches for clinical applications.
Effect of the trap net emptying method on release mortality of Atlantic salmon estimated by a Bayesian system model
Authors: Ruokonen Timo J. , Pulkkinen Henni , Mäntyniemi Samu , Erkinaro Jaakko , Suuronen Petri 
Published: May 2023

AbstractWe evaluated the effect of emptying techniques of a pontoon trap on mortality of Atlantic salmon on their spawning migration along the Finnish coast of the northern Baltic Sea by tagging and releasing fish from commercial trap nets. Two methods currently used, a traditional emptying chute and a lifting bag, were compared. The lifting bag has been developed primarily for minimising injuries for fish during emptying. A custom‐built Bayesian system model was used for mortality estimation. We also explored external injuries of salmon and compared the probability of getting an injury between the emptying methods. The mean probability of salmon dying due to release from a trap with an emptying chute was 24% (90% HDI 3%–43%), whereas that for salmon released from a trap with a lifting bag was 13% (90% HDI 1%–24%). Results showed a higher probability of injuries and longer air exposure time in salmon caught with a trap with an emptying chute, which may explain the observed difference in mortality. Manual handling of a lifting bag appears to pose a clear work safety risk for fishers. It is noteworthy that the role of release mortality for northern Baltic salmon stocks is small because the number of salmon released in coastal fishery is currently low.
Recessive CHRM5 variant as a potential cause of neurogenic bladder
Authors: Schneider Sophia , Schierbaum Luca , Burger Wessel A. C. , Seltzsam Steve , Wang Chunyan , Zheng Bixia , Wu Chen‐Han Wilfred , Nakayama Makiko , Connaughton Dervla M. , Mann Nina , Shalaby Mohamed A. , Kari Jameela A. , ElDesoky Sherif , Tasic Velibor , Eid Loai A. , Shril Shirlee , Thal David M. , Hildebrandt Friedhelm 
Published: May 2023

AbstractNeurogenic bladder is caused by disruption of neuronal pathways regulating bladder relaxation and contraction. In severe cases, neurogenic bladder can lead to vesicoureteral reflux, hydroureter, and chronic kidney disease. These complications overlap with manifestations of congenital anomalies of the kidney and urinary tract (CAKUT). To identify novel monogenic causes of neurogenic bladder, we applied exome sequencing (ES) to our cohort of families with CAKUT. By ES, we have identified a homozygous missense variant (p.Gln184Arg) in CHRM5 (cholinergic receptor, muscarinic, 5) in a patient with neurogenic bladder and secondary complications of CAKUT. CHRM5 codes for a seven transmembrane‐spanning G‐protein‐coupled muscarinic acetylcholine receptor. CHRM5 is shown to be expressed in murine and human bladder walls and is reported to cause bladder overactivity in Chrm5 knockout mice. We investigated CHRM5 as a potential novel candidate gene for neurogenic bladder with secondary complications of CAKUT. CHRM5 is similar to the cholinergic bladder neuron receptor CHRNA3, which Mann et al. published as the first monogenic cause of neurogenic bladder. However, functional in vitro studies did not reveal evidence to strengthen the status as a candidate gene. Discovering additional families with CHRM5 variants could help to further assess the genes' candidate status.
An interpenetrating polymer networks structure formed by in situ crosslinking of flame retardant for improvement in mechanical properties and flame retardancy of epoxy resins
Authors: Zhao Haihan , Li Junwei , Wang Rui , Liu Huaiyin , Sun Jichang , Wu Jing , Zheng Penglun 
Published: May 2023

AbstractEpoxy resins (EPs) possess flammable characteristics inherently, and various methods have been utilized to enhance their flame retardancy. However, the improvement of flame retardancy may reduce its mechanical properties at the same time. Hence, this work synthesized a novel interpenetrating polymer network structure by introducing double bonds into flame retardants based on crosslinking strategy. When the flame retardant was crosslinked inside the EPs, the increased crosslink density improved the mechanical properties and the fire retardancy of the EP thermosets. With the addition of just 3 wt% of a crosslinked flame retardant, its vertical combustion achieved grade V‐0 and had a limited oxygen index of 31.8%. In the cone calorimeter test, the heat release rate was significantly decreased by 56.7% compared with pure EP when the crosslinked flame retardant reached 5 wt%. The study on the pyrolysis behavior of the material and the residual char further revealed that the flame retardant has a biphasic flame‐retardant effect.
Red mud waste/nanoclay/polystyrene‐modified epoxy hybrid composites: Mechanical, thermal, and flammability properties
Authors: Özmeral Nimet , Soydal Ulku , Kocaman Suheyla , Ahmetli Gulnare 
Published: May 2023

AbstractIn this study, bisphenol A‐type epoxy (ER) and epoxy phenol novolac resins (EPN) with two amine‐type curing agents (KH 816 and IPOX EH 2041) having different total amine values were selected. The mechanical properties and density of the EPN resin were found higher in the case of both curing agents. EPN was modified with polystyrene (EPN‐PS) and used as a matrix using an IPOX hardener. Nano‐ and hybrid composites were prepared with pristine and modified with tetramethylammonium chloride nano montmorillonite (NC and MNC), and red mud waste (RMW). The chemical structure was elucidated by the Fourier transform infrared (FT‐IR). The composites were characterized by scanning electron microscopy and x‐ray diffraction. Appropriate PS and NC ratio was accepted as 4% and 2% by weight, respectively. Curing degrees calculated from the FT‐IR spectra of ER, EPN, and EPN‐PS were 99.3%, 99.9%, and 86.5%, respectively. A comparative study of the two binary systems; (i) 2 wt% NC‐(15–35) wt% RMW; and (ii) 2 wt% of MNC‐(15–35) wt% of RMW on the mechanical, thermal, and flammability properties of EPN‐PS matrix was carried out. The appropriate RMW ratio was 30 wt%. Hybrid composites with 25–30 wt% RMW can be considered self‐extinguishing materials.
Effects of Promoter and Calcination Temperatures on the Catalytic Performance of Y Promoted Co/WC‐AC for Dry Reforming of Methane
Authors: Li Tianshan , Wang Jiming , Zhang Guojie , Liu Jun , Wang Ying , Zhao Yuqing , Li Guoqiang , Lv Yongkang 
Published: May 2023

AbstractCH4‐CO2 reforming is a good way to convert two environmentally harmful greenhouse gases into a high value syngas. However, the catalytic activity and stability of the catalysts need to be further improved. In this paper, the effects of promoter Y and calcination temperature on the catalytic activity and stability of Co/WC‐AC catalysts were investigated. The catalysts were characterized by BET, XRD, CO2‐TPD, H2‐TPR, XPS, and TG‐DSC. XPS and H2‐TPR. The results indicated that the introduction of Y decreased the reduction temperature of Co2O3 species and facilitated the formation of Co2+ species. Meanwhile, the addition of Y increased the content of lattice oxygen on the catalyst surface, which enhanced the carbon elimination capacity of the catalyst. The TG‐DSC results showed that the activity and stability of the catalysts calcined at 550 °C were poor due to the presence of carbon materials with weak carbon interactions on the catalyst support surface. Meanwhile, the catalyst calcined at 700 °C lead to the collapse of the pores due to the high calcination temperature, which eventually led to the decrease of the catalyst stability. It was found that the Co‐Y/WC‐AC catalysts prepared at the calcination temperature of 600 °C had the best catalytic activity and stability.
What are quantitative traits and how can they be used in autism research?
Authors: Lyall Kristen 
Published: May 2023

AbstractQuantitative traits are measurable characteristics distributed along a continuous scale thought to relate to underlying biology. There is growing interest in the use of quantitative traits in behavioral and psychiatric research, particularly in research on conditions diagnosed based on reports of behaviors, including autism. This brief commentary describes quantitative traits, including defining what they are, how we can measure them, and key considerations for their use in autism research. Examples of measures include behavioral report scales like the Social Responsiveness Scale and Broader Autism Phenotype Questionnaire, as well as biological measurements, like certain neuroimaging metrics; such measures can capture quantitative traits or constructs like the broader autism phenotype, social communication, and social cognition. Quantitative trait measures align with the Research Domain Criteria (RDoC) approach and can be used in autism research to help gain a better understanding of causal pathways and biological processes. They can also be used to aid identification of genetic and environmental factors involved in such pathways, and thereby lead to an understanding of influences on traits across the entire population. Finally, in some cases, they may be used to gauge treatment response, and assist screening and clinical characterization of phenotype. In addition, practical benefits of quantitative trait measures include improved statistical power relative to categorical classifications and (for some measures) efficiency. Ultimately, research across autism fields may benefit from incorporating quantitative trait measures as a complement to categorical diagnosis to advance understanding of autism and neurodevelopment.
High Energy Density Li/Ni/Co‐Free O3/P2 Sodium Layered Oxide Intergrowth for Sodium‐Ion Batteries
Authors: Maughan Philip A. , Naden Aaron B. , Irvine John T. S. , Armstrong A. Robert 
Published: May 2023

AbstractSodium‐ion batteries have attracted widespread interest due to the potential for providing safe and cheap energy storage. However, large scale use of sodium‐ion batteries is limited by insufficient performance from positive electrode materials, while also avoiding the use of expensive and toxic elements. Here, we present a bi‐phasic sodium layered oxide material, O3/P2‐Na0.75Mn0.35Fe0.35Ti0.1Al0.1Cu0.1O2, free of Li, Ni, and Co, which delivered high energy densities up to 420 Wh kg−1, discharge potential of 3.03 V, and high capacity retention of 80 % over 70 cycles in half cells (292 Wh kg−1 in full cells). Crucially, the high Na content is sufficient to provide high energy densities in full cell format. The intergrown nature of the material was confirmed by TEM and SAED analysis, while ex‐situ XRD studies revealed the two phases undergo complementary c‐parameter evolution, reducing overall volume change. These results demonstrate the potential for future commercialisation of bi‐phasic materials utilizing only Earth abundant elements.
Associations among stressors across the lifespan, disability, and relapses in adults with multiple sclerosis
Authors: Polick Carri S. , Ploutz‐Snyder Robert , Braley Tiffany J. , Connell Cathleen M. , Stoddard Sarah A. 
Published: May 2023

AbstractIntroductionStress and adversity during childhood, adolescence, and adulthood could impact the present and future health and well‐being of people with multiple sclerosis (PwMS); however, a lifespan approach and nuanced stressor data are scarce in this nascent area of research. Our aim was to examine relationships among comprehensively measured lifetime stressors and two self‐reported MS outcomes: (1) disability and (2) relapse burden changes since COVID‐19 onset.MethodsCross‐sectional data were collected from a nationally distributed survey of U.S.‐based adults with MS. Hierarchical block regressions were used to sequentially evaluate contributions to both outcomes independently. Likelihood ratio (LR) tests and Akaike information criterion (AIC) were used to evaluate additional predictive variance and model fit.ResultsA total of 713 participants informed either outcome. Most respondents (84%) were female, 79% had relapsing remitting multiple sclerosis (MS), and mean (SD) age was 49 (12.7) years. Childhood (R2 = .261, p < .001; AIC = 1063, LR p < .05) and adulthood stressors (R2 = .2725, p < .001, AIC = 1051, LR p < .001) contributed significantly to disability, above and beyond prior nested models. Only adulthood stressors (R2 = .0534, p < .001; AIC = 1572, LR p < .01) significantly contributed above the nested model for relapse burden changes since COVID‐19.ConclusionsStressors across the lifespan are commonly reported in PwMS and could contribute to disease burden. Incorporating this perspective into the “lived experience with MS” could facilitate personalized health care by addressing key stress‐related exposures and inform intervention research to improve well‐being.
LncRNA HClnc1 facilitates hepatocellular carcinoma progression by regulating PKM2 signaling and indicates poor survival outcome after hepatectomy
Authors: Zhu Qian , Lei Zhengqing , Xu Chang , Zhang Zheng , Yu Zeqian , Cheng Zhangjun , Xiao Pengfeng , Li Shufeng , Yu Weiping , Zhou Jiahua 
Published: May 2023

AbstractAimLong noncoding RNAs (lncRNAs) are key mediators with a wide range of pathophysiological functions, but their role in human hepatocellular carcinoma (HCC) is still unclear.MethodsAn unbiased microarray study evaluated a novel lncRNA, HClnc1, that is linked to the development of HCC. In vitro cell proliferation assays and an in vivo xenotransplanted HCC tumor model were performed to determine its functions, followed by antisense oligo‐coupled mass spectrometry to identify HClnc1‐interacting proteins. To study relevant signaling pathways, in vitro experiments were performed, including chromatin isolation by RNA purification, RNA immunoprecipitation, luciferase, and RNA pull‐down assay.ResultsHClnc1 levels were considerably greater in patients with advanced tumor‐node‐metastatic stages, and it was found to be inversely connected to survival rates. Moreover, the proliferative and invasive potential of the HCC cells was attenuated by HClnc1 RNA knockdown in vitro, while HCC tumor growth and metastasis were found to be reduced in vivo. HClnc1 interacted with pyruvate kinase M2 (PKM2) to prevent its degradation and thus facilitated aerobic glycolysis and PKM2‐STAT3 signaling.ConclusionsHClnc1 is involved in a novel epigenetic mechanism of HCC tumorigenesis and PKM2 regulation. HClnc1 is not only a more accurate prognostic indicator of HCC but also a potential therapeutic target for HCC treatment.
A nurse‐led intervention in patients with newly diagnosed cancer and Type 2 diabetes: A pilot randomized controlled trial feasibility study
Authors: Scarton Lisa , Nelson Tarah , Jo Ara , O’Neal LaToya J. , Yao Yingwei , Huggins Shavondra , Legaspi Anatolia B. , McClaren Mariah J. , Cabassa Jake S. , Burgos Melendez Joan M. , Munoz‐Pena Juan M. , Markham Merry J. , Murphy Martina C. , Chatzkel Jonathan A. , Rogers Sherise , George Thomas J. 
Published: May 2023

AbstractBackgroundUndiagnosed Type 2 diabetes (T2D) has been associated with advanced stage cancer at diagnosis, higher mortality, and lower long‐term all‐cause survival. This was a RCT pilot study to examine the feasibility of a nurse‐led T2D intervention for adults with newly diagnosed cancer (≤3 months), and T2D, undiagnosed or untreated with medication, conducted at an outpatient oncology clinic affiliated with a large academic institution.MethodsParticipants needed to meet the eligibility criteria including a HbA1c level between 6.5% and 9.9%. Randomization was 1:1 to a 3‐month intervention that consisted of nursing‐led diabetes education and immediate initiation of metformin versus referral to primary care for usual care (control).ResultsThree hundred and seventy nine patients were screened using EHR, 55 agreed to participate, and 3 had eligible HbA1c levels and were randomized in the study. Primary reasons for study exclusion included life expectancy ≤2 years (16.9%), current use or inability to tolerate metformin (14.8%), and abnormal labs that contraindicated metformin use (13.9%).ConclusionThis study was not feasible due to recruitment inefficiencies, but acceptable to all who qualified.
Inversion alleviation for stable elastic body simulation
Authors: Lee JaeHyun , Kim Seung‐wook , Um Kiwon , Kee Min Hyung , Han JungHyun 
Published: May 2023

AbstractIn general, it is not easy to simulate an elastic body that undergoes large deformations. Especially when its elements are inverted or tangled, that is, when its vertices penetrate its polygons, simulation often fails. In this paper, we propose a simple yet highly effective method for alleviating the inversion problems of elastic bodies. Our experiments made with typical optimization‐based solvers demonstrate that the proposed method successfully stabilizes the solvers and produces visually plausible motions. We believe that our method can be widely adopted by a variety of state‐of‐the‐art elastic‐body simulators thanks to its simplicity.
Enhancing Catalytic Performance with Sol‐Gel Hydrotalcite‐Derived Nickel Oxide Catalysts for Dry Reforming of Methane: An Examination on Reactivity and Coke Formation
Authors: Gonzalez Caranton Alberth Renne , Stavale Fernando , Annese Emilia , Gaioto Carolina , Checca Huaman Noemi Raquel , Assaf José Mansur 
Published: May 2023

AbstractHydrotalcite‐based materials are preferred as catalysts due to their versatility and easiness of their synthesis. This work studies supported nickel catalysts made from hydrotalcites through sol‐gel synthesis, Ni‐EDTA impregnation, and coprecipitation. The synthetized hydrotalcites present nanocapsular morphology and dispersed nickel nano‐oxide particles after calcination at 500 °C. The catalysts were evaluated at 600 °C and 800 °C for 8 hours and demonstrated high conversions and varying yields, with sol‐gel oxide catalysts (SgOxMix) showing the best performance with the highest reactivity and controlled coke formation at 800 °C after 14 hours of testing. The mixed oxide morphology promotes electronic effects and inhibits carbon encapsulation of metallic particles. Principal component analysis was performed to explain fluctuations in the reaction pathway.
Photodecarboxylase Displayed on Microbial Cell‐Surface for Enhanced Biocatalytic Performance
Authors: Li Zuhui , Ge Ran , Tan Ling , Zhang Wuyuan , Zhang Yanfei 
Published: May 2023

AbstractSurface display technology has emerged as a powerful tool for enhancing the stability, accessibility, and reusability of enzymes. Fatty acid photodecarboxylase from Chlorella variabilis NC64A (CvFAP) is capable of catalyzing decarboxylation reactions from free fatty acids to alkanes under blue light, however, its stability and reusability in catalytic cycles remain to be improved. Herein, we successfully displayed CvFAP on the surface of Escherichia coli cells utilizing full‐length ice nucleation protein as the anchor protein. By comparing the performance of the surface displayed CvFAP with whole‐cells harboring CvFAP, it was found that surface displaying of CvFAP significantly reduces the reaction time and enhances substrate accessibility, resulting in a turnover number of 9972. Also, compared to soluble enzymes, the surface displayed CvFAP exhibits enhanced stability and reusability in the decarboxylation reaction. Furthermore, the broad substrate scope of surface displayed CvFAP suggests its potential for large‐scale hydrocarbon and fatty chemicals production. Overall, our results highlight the value of surface display approach in broadening the application of photodecarboxylase.
Selective Peroxygenase‐Catalysed Oxidation of Toluene Derivates to Benzaldehydes
Authors: Wang Yutong , Teetz Niklas , Holtmann Dirk , Alcalde Miguel , van Hengst Jacob M. A. , Liu Xiaoxiao , Wang Mengfan , Qi Wei , Zhang Wuyuan , Hollmann Frank 
Published: May 2023

AbstractBiocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio‐ and chemoselectivity issues. In this contribution we address both challenges by a combined reactant‐ and reaction engineering approach. We demonstrate that the peroxygenase‐catalysed transformation of ring‐substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level.
Counselor educator workload and burnout in the era of COVID‐19
Authors: DeDiego Amanda C. , McGrath Andrea M. , Maurya Rakesh K. , Szepe Arden A. 
Published: May 2023

AbstractThe COVID‐19 pandemic brought disruption to teaching and other aspects of workload in higher education. The current study sampled 126 counselor educators about workload, compassion satisfaction, burnout, and job satisfaction. Results indicated that faculty workload and administrative responsibilities increased for counselor educators during the pandemic without adequate compensation or support.
A combined method for stability analysis of linear time invariant control systems based on Hermite‐Fujiwara matrix and Cholesky decomposition
Authors: Fatoorehchi Hooman , Ehrhardt Matthias 
Published: May 2023

AbstractIn this paper, we have developed an integrative method for checking the stability of linear time‐invariant (LTI) systems as well as nonlinear continuous‐time ones. In our method, we first apply the iterative Faddeev–Leverrier algorithm to obtain the characteristic polynomial of the LTI system. Subsequently, the associated Hermite‐Fujiwara matrix will be evaluated by a particularly efficient technique for the calculation of the Bézoutian matrices. The positive‐definiteness of the Hermite‐Fujiwara form, as the stability criterion, is next tested by performing the Cholesky decomposition. Our method is extended to assess the local stability of nonlinear continuous‐time systems with the help of the Jacobian matrix concept. The proposed method is demonstrated to approximately be 2.2 times faster than the classical Hurwitz algorithm in average, at least for matrices with dimensions less than 40, according to a performed central processing unit (CPU) time analysis. For the sake of illustration, four numerical examples are given, including dynamical models for a real‐world hydrolysis reactor and a well‐mixed bioreactor.