bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronisation of wearable inertial measurement units based on magnetometer data
Authors: Spilz Andreas , Munz Michael 
Published: January 2023

Abstract

Objectives
Synchronisation of wireless inertial measurement units in human movement analysis is often achieved using event-based synchronisation techniques. However, these techniques lack precise event generation and accuracy. An inaccurate synchronisation could lead to large errors in motion estimation and reconstruction and therefore wrong analysis outputs.

Methods
We propose a novel event-based synchronisation technique based on a magnetic field, which allows sub-sample accuracy. A setup featuring Shimmer3 inertial measurement units is designed to test the approach.

Results
The proposed technique shows to be able to synchronise with a maximum offset of below 2.6 ms with sensors measuring at 100 Hz. The investigated parameters suggest a required synchronisation time of 8 s.

Conclusions
The results indicate a reliable event generation and detection for synchronisation of wireless inertial measurement units. Further research should investigate the temperature changes that the sensors are exposed to during human motion analysis and their influence on the internal time measurement of the sensors. In addition, the approach should be tested using inertial measurement units from different manufacturers to investigate an identified constant offset in the accuracy measurements.
Avoidance of axonal activation in epiretinal implants using short biphasic pulses
Authors: Werginz Paul , Corna Andrea , Zeck Günther 
Published: January 2023

Abstract
Retinal implants allow patients suffering from degenerative retinal diseases to regain visual percepts. Despite considerable effort in developing and improving retinal neuroprostheses in the last decades, the restored vision in patients does not achieve sufficient quality. The elicited percepts do not accurately match the stimulating pixels and therefore the formation of high acuity vision is hindered. One of the main obstacles in epiretinal implants is the concurrent activation of cells close to a stimulating electrode and cells that have their axons traversing the electrode. In this study, we use computational modeling to examine the effect of pulse duration on the selectivity of focal versus non-focal activation. Our results suggest that biphasic pulses in the range of 10-20 microseconds can prevent axonal activation while still reliably activating target neurons.
The evoked compound nerve action potential is shaped by the electrical pulse-width
Authors: Proksch Johannes , Vargas Luna Jose Luis , Eickhoff Steffen , Mayr Winfried , Jarvis Jonathan C. 
Published: January 2023

Abstract

Introduction: Despite its central role in medicine electrical stimulation (ES) is still limited by its selectivity. Different reports did assess effects of different waveforms, intensities, and frequency on the activation threshold of nerve fibres with different diameters. We aimed to extend this knowledge by investigating the effect of short monophasic rectangular pulses (1, 2, 5, 10, 50, 100 and 200 μs) on the recruitment order. Methods:The sciatic nerve of rats was stimulated, and the evoked compound nerve action potential (CNAP) measured at two sites on the tibialis nerve, using epineural electrodes. Changes in delay, amplitude, and the shape of the CNAP were analyzed. Results:The amplitude and delay of the CNAP were significantly affected by the pulse-width (PW). The delay and duration of the compound nerve action potential increased with longer PW, while the amplitude decreased. Discussion:Found changes are likely caused by changes in the time point of excitation of individual neuron fibres, depending on electrical field strength and exposure time. This might be of particular interest when selecting PWs for design and validation of stimulation patterns and analysis of experimental and clinical observations.
Real-world assessment of the clinical performance of COVID-VIRO ALL IN rapid SARS-CoV-2 antigen test
Authors: Pighi Laura , Henry Brandon M. , De Nitto Simone , Gianfilippi Gianluca , Salvagno Gian Luca , Lippi Giuseppe 
Published: January 2023

Abstract

Objectives
Since the external validation of severe acute respiratory syndrome coronavirus 2 antigen rapid diagnostic tests (SARS-CoV-2 RDT-Ags) is a necessary requisite before they can be introduced into routine clinical practice, this study reports the results of a real-world assessment of the clinical performance of the new COVID-VIRO ALL IN device.

Methods
The study population consisted in 165 outpatients (median age: 43 years, range: 14–68 years; 66.1% females) who had paired nasal and nasopharyngeal samples collected upon hospital presentation. The samples were concomitantly tested with the AAZ-LMB COVID-VIRO ALL IN SARS-CoV-2 RDT-Ag and with Cepheid Xpert Xpress SARS-CoV-2 real-time reverse transcription polymerase chain reaction (RT-PCR).

Results
The number of subjects with positive RT-PCR results (i.e., mean Ct value <45) was 116 (70.3%), 109 (66.1%) and 86 (52.1%) with mean Ct values <37 and <30, respectively. In all RT-PCR positive samples, COVID-VIRO ALL IN displayed 78.8% agreement, 0.698 sensitivity, 1.000 specificity, 0.583 negative predictive value (NPV) and 1.000 positive predictive value (PPV) compared to RT-PCR. The median Ct value of samples testing positive with COVID-VIRO ALL IN was significantly lower than those testing negative (22.8 vs. 32.2; p<0.001). In samples with high viral load (i.e., Ct value <30), COVID-VIRO ALL IN displayed 92.1% agreement, 0.895 sensitivity, 0.949 specificity, 0.983 NPV and 0.951 PPV compared to RT-PCR.

Conclusions
Although the diagnostic performance of COVID-VIRO ALL IN do not exactly match those of the manufacturer, its high NPV in high viral load samples would enable fast-track and rapid identification of highly contagious subjects.
First-principles calculations to investigate the thermal response of the ZrC(1−x)N
x
ceramics at extreme conditions
Authors: Alipour Hassan , Hamedani Ali , Alahyarizadeh Ghasem 
Published: January 2023

Abstract
We present the thermodynamic properties of ZrC(1−x)N
x
ceramics at elevated temperature (0–1,000 K) and pressure (0–150 GPa) conditions, explored by density functional theory. We implemented the Debye–Grüneisen quasi-harmonic model in our calculations. In our investigation, we cover elastic constants, elastic moduli, compressibility, ductility/brittleness, hardness, sound velocities, minimum thermal conductivity, melting temperature, anisotropy indices, isothermal bulk modulus, heat capacities, entropy, Debye temperature, Grüneisen parameter, thermal expansion coefficient, and thermal pressure. We address the effect of the structural anisotropy and bonding nature of ZrC(1−x)N
x
compounds on their thermal response to extreme conditions. Considering ZrC(1−x)N
x
with the x in the range of 0.0, 0.25, 0.5, 0.75, and 1.0, ZrC0.50N0.50 stands out in the response to the applied conditions. At higher temperatures, the thermal expansion of the ZrC0.50N0.50 shows a smaller increase, which makes it a favorable candidate for coating material in cutting tools against commonly used ZrN and ZrC ceramics. Similar behavior is observed for the heat capacity by increasing pressure at higher temperatures, where a smaller reduction is observed. It could be interpreted as a more stable response regarding the application-specific design conditions.
Dual uniformities in function spaces over uniform continuity
Authors: Gupta Ankit , Sarma Ratna Dev , Alshammari Fahad Sameer , George Reny 
Published: January 2023

Abstract
The notion of dual uniformity is introduced on

U
C

(

Y
,
Z

)

UC(Y,Z)

, the uniform space of uniformly continuous mappings between

Y

Y

and

Z

Z

, where

(

Y
,
V

)

(Y,{\mathcal{V}})

and

(

Z
,
U

)

(Z,{\mathcal{U}})

are two uniform spaces. It is shown that a function space uniformity on

U
C

(

Y
,
Z

)

UC(Y,Z)

is admissible (resp. splitting) if and only if its dual uniformity on

U

Z

(

Y

)

=

{

f

2

−
1

(

U

)

∣

f
∈
U
C

(

Y
,
Z

)

,
U
∈
U

}

{{\mathcal{U}}}_{Z}(Y)=\{{f}_{2}^{-1}(U)\hspace{0.33em}| \hspace{0.33em}f\in UC(Y,Z),U\in {\mathcal{U}}\}

is admissible (resp. splitting). It is also shown that a uniformity on

U

Z

(

Y

)

{{\mathcal{U}}}_{Z}(Y)

is admissible (resp. splitting) if and only if its dual uniformity on

U
C

(

Y
,
Z

)

UC(Y,Z)

is admissible (resp. splitting). Using duality theorems, it is also proved that the greatest splitting uniformity and the greatest splitting family open uniformity exist on

U

Z

(

Y

)

{{\mathcal{U}}}_{Z}(Y)

and

U
C

(

Y
,
Z

)

UC(Y,Z)

, respectively, and these two uniformities are mutually dual splitting uniformities.
On-chip micro-ring resonator array spectrum detection system based on convex optimization algorithm
Authors: Chen Xinyang , Gan Xuetao , Zhu Yong , Zhang Jie 
Published: January 2023

Abstract
We propose an all on-chip micro-ring resonator array spectrum detection system (MRRAS). Micro-ring resonator array as the core is used to construct the transmission matrix of the system. The theoretical analysis of the spectrum detection system is completed with waveguide transmission theory and spectrum construction method based on convex optimization algorithm. In the experiment, we obtain the priori information of the transmission matrix of the system, then detect the output intensity of unknown spectrum through MRRAS, and construct the under-determined matrix equations when the number of micro-rings is much smaller than that of reconstructed wavelengths. Convex optimization algorithm is employed to obtain the least norm solution of the under-determined matrix equations, which enables fast spectrum reconstruction. The experimental results show that the spectrum detection system is constructed using three micro-ring resonators with 4 μm radius, enabling the compact footprint. In addition, the silicon nitride based photonic platform is fully compatible with standard complementary metal oxide semiconductor (CMOS) processes. The system operating bandwidth is more than 12 nm and the resolution is better than 0.17 nm.
Crystal structure of 7-hydroxy-6-(2-hydroxyethyl)-2H-chromen-2-one, C11H10O4
Authors: Huang Hua , Yang Jing , Sun Yi-chun , Ye Jiang-Hai , He Kang , Zou Juan 
Published: January 2023

Abstract
C11H10O4, monoclinic, Pn (no. 7), a = 4.8622(5) Å, b = 6.7853(7) Å, c = 14.3349(17) Å, β = 96.556(3)°, V = 469.84(9) Å3, Z = 2, Rgt
(F) = 0.0512, wRref
(F
2) = 0.1249, T = 273(2) K.
On representation of conflict in modern academic discourse
Authors: Vartanova Elena , Gladkova Anna , Dunas Denis 
Published: January 2023

Abstract
This article discusses media researchers’ understanding of the term “conflict,” what types of experience objects social scientists include in this category, and the possibility of categorization and theoretical understanding of these objects in the context of modern media research in Russia and abroad. Also discussed are the theoretical issues of the interaction between media and conflict, theory-based methodology of conflict research, and the types and key subjects of conflict, which have become the subjects of empirical research on scientific papers published in major media academic journals at home and abroad. In discussing the study’s empirical results, the necessity of cultivating ethical and moral values in the media, according to Habermas’s communicative behavior theory where he opposes the anti-values of conflict, was raised.
Differences Family Support and Posyandu Visit Frequency Between Stunted and Non Stunted 12-59 Months Old Toddler
Authors: Puspitasari Vanny , Nuryanto Nuryanto , Kurniawati Dewi Marfu'ah 
Published: January 2023

Stunting are common at the age of 12-59 months. Some things that can affect the growth of toddler are family, parenting patterns, health services and environmental conditions. Family support is very important for children especially for their nutritional status. An example of health services for toddlers is Posyandu. Posyandu has benefits for society include monitoring the growth of toddlers so they do not suffer from stunting. The aim of the study was to determine differences family support and Posyandu visit frequency between stunted and non stunted 12-59 months old toddlers at Tambakrejo village Pemalang regency. This is a cross sectional study. The research subjects were toddlers 12-59 months old in Tambakrejo village. Stunted was determined by height for age z-score <-2SD. Independent t-test dan Mann Whitney test was conducted to determine differences family support and Posyandu visit frequency between stunted and non stunted toddler. Family support score in the stunted toddler group was 35,77 and Posyandu visit frequency was 5,40 times. Family support score in the non stunted toddler group was 54,27 dan Posyandu visit frequency was 8,97 times. There was a significant difference family support and Posyandu visit frequency between stunted and non stunted toddlers. Non stunted toddlers have better family support compared to stunted toddlers. Posyandu visit frequency of stunted toddlers is lower than non stunted toddlers.
A Customized Triggers Program: A Children’s Hospital’s Experience in Improving Trigger Usability
Authors: Reinhart Richelle M. , Safari-Ferra Parissa , Badh Ranjodh , Bhattarai Sopnil , Abera Solomon , Saha Anit , Herstek Jessica , Shah Rahul K. , Parikh Kavita 
Published: January 2023

BACKGROUND
Despite the growth of patient safety programs across the United States, errors and adverse events remain a source of patient harm. Many hospitals rely on retrospective voluntary reporting systems; however, there are opportunities to improve patient safety using novel tools like trigger programs.

METHODS
Children’s National Hospital developed a unique pediatric triggers program that offers customized, near real-time reports of potential safety events. Our team defined a measure to quantify clinical utility of triggers, termed “trigger signal,” as the percentage of cases that represent true adverse or near-miss events (numerator) per total triggers activated (denominator). Our key driver diagram focused on unifying the program structure, increasing data analytics, promoting organizational awareness, and supporting multidisciplinary end user engagement. Using the model for improvement, we aimed to double overall trigger signal from 8% to 16% and sustain for 12 months.

RESULTS
The trigger signal increased from 8% to 41% and sustained during the coronavirus disease 2019 pandemic. A balancing measure of time to implement a new trigger decreased. Key interventions to increase trigger signal were change in the program structure, increasing stakeholder engagement, and development of self-service reports for end users.

CONCLUSIONS
Children’s National Hospital’s triggers program highlights successful evolution of an iterative, customized approach to increase clinical utility that hospitals can implement to impact real-time patient care. This triggers program requires an iterative, customized approach rather than a “1-size-fits-all,” static paradigm to add a new dimension to current patient safety programs.
Effect of Voxel Size of Micro-CT on the Assessment of Root Canal Preparation
Authors: Pinto Jader Camilo , Lucas-Oliveira Everton , Bonagamba Tito Jose , Guerreiro-Tanomaru Juliane Maria , Tanomaru-Filho Mario 
Published: January 2023

The aim of this study was to assess the influence of micro-computed tomography (micro-CT) voxel size on evaluation of root canal preparation using rotary heat-treated nickel-titanium files. Curved mesial root canals of mandibular molars were prepared using ProDesign Logic 30/.05 (PDL) or HyFlex EDM 25/.08 (HEDM) (n=12). The specimens were scanned using micro-CT with 5μm of voxel size before and after root canal preparation. Images with sub-resolution of 10 and 20μm voxel sizes were obtained. The percentage of volume increase, debris and uninstrumented root canal surface were analyzed in the different voxel sizes. Data were compared using unpaired Student’s t-test and ANOVA statistical tests (α=0.05). No differences were observed for percentage of volume increase, debris and instrumented surface between the root canals prepared by PDL and HEDM (p>0.05). Both systems promoted higher percentage of debris in the apical third compared to the middle third (p<0.05). After instrumentation using PDL the percentage of uninstrumented surface was highr in the apical third than middle third only when analysis were performed at 5µm (p<0.05). When comparing the different voxel sizes (5,10 or 20µm), both groups showed different means for the variables, with no significant difference (p>0.05). PDL and HEDM had similar root canal preparation capacity. Micro-CT images using different voxel sizes did not influence the results of volume increase and debris evaluation. However, images at 5µm showed greater accuracy to evaluate the percentage of uninstrumented surfaces.
Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for determination of nandrolone and testosterone in human urine
Authors: Rezaee Mohammad 
Published: January 2023

AbstractDispersive liquid-liquid microextraction (DLLME) and high performance liquid chromatography – UV detection was presented for extraction and determination of nandrolone and testosterone in human urines. Chloroform at microliter volume level and acetonitrile were used as extraction and dispersive solvents, respectively. The main advantages of method are high speed, high enrichment factor, high recovery, good repeatability and extraction solvent volume at µL level. The influence of several variables (e.g. type and volume of disperser and extraction solvents, ionic strength, etc.) on the performance of the sample preparation step was carefully evaluated. Under the optimum conditions, the calibration graphs were linear in the range of 5–500 μg L−1 with detection limit of 2.5 μg L−1 for both of them. The relative standard deviation (R.S.D.s) for five replicate measurements of nandrolone and testosterone were 9.4% and 8.8%, respectively. The relative recoveries of nandrolone and testosterone in urine sample at spiking level of 25.0 μg L−1 are ranged between 86.4% and 98%. DLLME combined with HPLC-UV is a fast, simple and efficient method for the determination of nandrolone and testosterone in human urines.
ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries
Authors: Ma Zihan , Mao Chenfeng , Jia Yiting , Yu Fang , Xu Ping , Tan Ying , Zou Qing-Hua , Zhou Xu-Jie , Kong Wei , Fu Yi 
Published: January 2023

Significance Statement
Complement factor H (CFH) dysfunction by an incomplete underlying mechanism causes various complement-mediated renal injuries. We identified metalloprotease ADAMTS7 as a novel binding protein of CFH that further degrades CFH and potentiates complement activation. ADAMTS7 deficiency alleviated CFH degradation and renal pathologies in lupus nephritis and renal ischemia-reperfusion injury in mice, but without affecting complement-dependent bactericidal activity. The investigation revealed a novel mechanism to explain CFH dysfunction in complement-mediated renal injuries. ADAMTS7 would be a promising target for anticomplement therapies that would potentially avoid increased risk of infection, which is the drawback of current strategies.

Background
The dysfunction of complement factor H (CFH), the main soluble complement negative regulator, potentiates various complement-induced renal injuries. However, insights into the underlying mechanism of CFH dysfunction remain limited. In this study, we investigated whether extracellular protease-mediated degradation accounts for CFH dysfunction in complement-mediated renal injuries.

Methods
An unbiased interactome of lupus mice kidneys identified CFH-binding protease. In vitro cleavage assay clarified CFH degradation. Pristane-induced SLE or renal ischemia-reperfusion (I/R) injury models were used in wild-type and ADAMTS7

−/−
mice.

Results
We identified the metalloprotease ADAMTS7 as a CFH-binding protein in lupus kidneys. Moreover, the upregulation of ADAMTS7 correlated with CFH reduction in both lupus mice and patients. Mechanistically, ADAMTS7 is directly bound to CFH complement control protein (CCP) 1–4 domain and degraded CCP 1–7 domain through multiple cleavages. In mice with lupus nephritis or renal I/R injury, ADAMTS7 deficiency alleviated complement activation and related renal pathologies, but without affecting complement-mediated bactericidal activity. Adeno-associated virus–mediated CFH silencing compromised these protective effects of ADAMTS7 knockout against complement-mediated renal injuries in vivo.

Conclusion
ADAMTS7-mediated CFH degradation potentiates complement activation and related renal injuries. ADAMTS7 would be a promising anticomplement therapeutic target that does not increase bacterial infection risk.
Sehî Bey Divanı’nda Geleneksel Oyun Kültürü
Authors: ÖZLÜK Işılay Pınar 
Published: January 2023

Öz
Klasik Türk Edebiyatı alanında yapılan sosyal hayat çalışmaları esas aldıkları döneme ait her türlü hususiyeti bünyesinde barındıran, kültür hayatımızla alakalı eşsiz malzemeyi içeren birer kaynaktır. Bu çalışmalar; halkın konuştuğu dilde bulunan atasözü ve deyim varlığına, yeme-içme kültürüne, giyim-kuşama, gelenek ve göreneklere, oyun ve eğlenceye, gündelik hayata, toplumsal yapılanmaya varan çok geniş bir yelpazeyi kapsamaktadır. Çalışmamız Sehî Bey Divanı’ndan hareketle 16. yüzyıl Osmanlı toplum hayatının bir parçası olan oyun ve eğlence kültürü üzerine tespitler içermektedir. O dönemde; halkı eğlendirmek amacıyla düzenlenen şenlikler, bayramlar vesilesiyle düzenlenen eğlenceler, düğünlerde yapılması gelenek haline gelen gösteriler çalışmaya dâhil edilmiştir. Eğlence ve oyun kültürünün unsurları olan halk arasında oynanan gelenekselleşmiş oyunlar, spor etkinlikleri ile âteşbâz, cânbâz ve tîgbâzların sergiledikleri hünerler sınıflandırılarak dikkatlere sunulmuştur. Elde edilen malzeme örnek beyitlerle somutlaştırılmış ve değerlendirilmiştir. Neticede ortaya çıkan veriler 16. yüzyıl Osmanlı Devleti’nin toplum hayatının bir bölümüne ışık tutması açısından dikkate değerdir.
El papel del apoyo social comunitario en la preservación de la salud mental, desde un enfoque de derechos. El caso de San Francisco, Montes de María
Authors: Ortegón Medina Twiggy Malena , Vinaccia Alpi Stefano , Pérez Cervantes Luis Eduardo , Vargas Moranth Rusvelt 
Published: January 2023

Las dinámicas de violencia en Colombia han dejado innumerables afectaciones y millones de víctimas que de manera resiliente han continuado con su existencia; pero ¿Cómo han logrado hacerlo en medio de la indiferencia de poblaciones urbanas que se mostraron ajenas así como instituciones que fueron ausentes como soporte? El objetivo de este artículo, es analizar la relación entre salud mental, apoyo social y conflicto armado, desde un enfoque de derechos; entendiendo la salud mental como un derecho humano. La investigación que dio origen a este texto, incorporó mediante el método cualitativo etnográfico. El trabajo de campo se desarrolló en la vereda San Francisco perteneciente al municipio de Ovejas, subregión Montes de María en el departamento de Sucre, Colombia. Se realizaron seis entrevistas individuales en profundidad y tres entrevistas grupales, organizadas y procesadas con N-vivo. En los resultados, se encontró que la cuestión pública de la salud mental como derecho humano toma fuerza para una subregión que ha sido históricamente afectada por la pobreza, la corrupción política y la violencia; concluyendo que se hace necesario que la política pública se dirija directamente a los espacios cotidianos de las víctimas del conflicto armado fuera de los entornos institucionalizados de tratamiento, aprovechando los saberes y estrategias de apoyo social que han construido las víctimas en sus tejidos sociales gracias a una histórica tradición de organización y resistencia.