bluuebunny/crossref_metadata_2025_split huggingface dataset:
A LncRNA gene polymorphism (rs1814343) is associated with the risk of coronary artery lesions in southern Chinese Kawasaki disease patients
Authors: Chen Wenchao , Chen Shuo , Tian Yan , Liu Yanqing , Chen Cheng , Wang Bingtong , Chen Chongfeng , Liu Fucheng 
Published: April 2023

AbstractBackgroundKawasaki disease (KD) is a multisystemic angiitis, and its most disastrous complication is coronary artery lesions (CALs). Recently, the role of long non‐coding RNAs (lncRNAs) in KD has been reported. rs1814343 is a lncRNA, but the relationship between the lncRNA rs1814343 polymorphism and KD risk remains elusive.MethodsWe enrolled 1625 Kawasaki disease patients (583 patients with CAL and 1042 without CAL) and 1000 healthy controls from a southern Chinese population. We genotyped the rs1814343 C > T polymorphism in KD and control patients using the TaqMan method. The odds ratio (OR) and 95% confidence interval (CI) were used to estimate the strength of the association.ResultsThere was no significant association between the lncRNA rs1814343 C > T polymorphism and KD susceptibility. However, we stratified patients in this study by CAL and sex. First, compared with the control groups, we found that the rs1814343 genotype increased risk for KD patients with CAL (TT vs. CC + CT: OR = 1.36, 95% CI = 1.08–1.71, p = 0.009). Moreover, when KD patients were stratified by CAL, the TT genotypes of this lncRNA polymorphism contributed to a relatively higher occurrence of KD with CAL than that was found in the CC/CT genotype patients (TT vs. CC + CT: OR = 1.35, 95% CI = 1.07–1.69, p = 0.011). In addition, our research suggested that the TT variant genotype in the lncRNA rs1814343 had an obvious risk of KD with CAL susceptibility in male children.ConclusionThe lncRNA rs1814343 C > T polymorphism was related to higher susceptibility of KD with CAL.
Acrodermatitis continua of Hallopeau with psoriatic arthritis treated with biologics and apremilast
Authors: Igari Shohei , Yamamoto Toshiyuki 
Published: April 2023

AbstractAcrodermatitis continua of Hallopeau (ACH) is a rare variant of acral pustular psoriasis, exclusively involving the distal phalanges and nails of the hands and feet. We herein report a rare case of concurrent ACH and psoriatic arthritis sine psoriasis presenting with dactylitis. The patient was successfully treated with biologics and apremilast.
An improved result for a class of Klein–Gordon–Maxwell system with quasicritical potential vanishing at infinity
Authors: Gan Canlin , Xiao Ting , Zhang Qiongfen 
Published: April 2023

AbstractThe following kind of Klein–Gordon–Maxwell system is investigated
where is a parameter, and V is vanishing potential. By using some suitable conditions on K and f, we obtain a Palais–Smale sequence by using Pohožaev equality and prove the ground‐state solution for this system by employing variational methods. Our result improves the related one in the literature.
Lipopolymeric Nanocarrier Enables Effective Delivery of CRISPR/Cas9 Expressing Plasmid
Authors: Sahel Deepak Kumar , Goswami Sangam Giri , Jatyan Reena , Kumari Anupma , Mittal Anupama , Ramalingam Sivaprakash , Chitkara Deepak 
Published: April 2023

AbstractCRISPR/Cas9 has proven its accuracy and precision for gene editing by making a double‐strand break at the predetermined site. Despite being a mainstream gene editing tool, CRISPR/Cas9 has limitations for its in vivo delivery due to the physico‐chemical properties such as high molecular weight, supranegative charge, degradation in the presence of nucleases, etc. Hereby, a cationic lipopolymer is explored for its efficiency in delivering CRISPR/Cas9 plasmid (pCas9) in vitro and in vivo. The lipopolymer is utilized to form blank cationic nanoplexes having a zeta potential of +15.8 ± 0.7 mV. Being cationic, the blank nanoplexes are able to condense the pCas9 plasmid at a ratio of 1:20 with a complexation efficiency of ≈98% and show a size and zeta potential of ≈141 ± 16 nm and 4.2 mV ± 0.7, respectively. The pCas9‐loaded nanoplexes show a transfection efficiency of ≈69% in ARPE‐19 cells and show ≈22% of indel frequency, indicating the successful translation of Cas9 protein and guide RNA in the cytosol. Further, they are found to be stable under in vivo environment when given intravenously in Swiss albino mice. These lipopolymeric nanoplexes can be a potential carrier for CRISPR plasmids for genome editing applications.
Judicial system reform and trade credit financing: Evidence from a quasi‐natural experiment
Authors: Cheng Bo , Lu Shiyu 
Published: April 2023

AbstractThis paper examines the impact of judicial system reform on trade credit financing using a quasi‐natural experiment in China. We find that the judicial system reform promotes the trade credit financing. The reform effect is stronger for firms that are non‐state‐owned, advocating trust culture orientation, and with high relationship‐specific investment level, high debt level, and low cash holdings level. Moreover, our results show that the increase in business transaction volume and the improvement of internal control quality are important channels to increase the trade credit financing. The judicial system reform has notably improved the total factor productivity and firm value.
A multiparameter radiomic model for accurate prognostic prediction of glioma
Authors: Li Yan , Bao Li , Yang Caiwei , Deng Zhenglong , Zhang Xin , Xu Pin , Su Xiaorui , Zeng Fanxin , Mehrabi Mir Q. U. , Yue Qiang , Song Bin , Gong Qiyong , Lui Su , Wu Min 
Published: April 2023

AbstractAn accurate prediction of prognosis is important for clinical treatments of glioma. In this study, a multiparameter radiomic model is proposed for accurate prognostic prediction of glioma. Three kinds of region of interest were extracted from preoperative postcontrast T1‐weighted images and T2 fluid‐attenuated inversion recovery images acquired from 140 glioma patients. Radiomics score (Radscore) was calculated and the conventional image features and clinical molecular characteristics that may be related to progression‐free survival (PFS) were evaluated. Five uniparameter and various combinations of biparameter and multiparameter models based on above characteristics were built. The performance of these models was evaluated by concordance index (C index), and the nomogram of the multiparameter radiomic model was constructed. The results show that the proposed multiparameter radiomic model has a better prediction performance than other models. In the training and validation sets, the calibration curves of the multiparameter radiomic model for the 1‐, 2‐, and 3‐year PFS probability demonstrate a high consistence between predictions and observations. In conclusion, this study demonstrates that the multiparameter radiomic model based on Radscore, conventional image features and clinical molecular characteristics can improve the prediction accuracy of glioma prognosis, which could be informative for individualized treatments.
Comparison of postoperative urinary continence and incontinence types between conventional and Retzius‐sparing robot‐assisted radical prostatectomy
Authors: Kadono Yoshifumi , Nohara Takahiro , Kawaguchi Shohei , Makino Tomoyuki , Naito Renato , Kadomoto Suguru , Iwamoto Hiroaki , Yaegashi Hiroshi , Shigehara Kazuyoshi , Izumi Kouji , Mizokami Atsushi 
Published: April 2023

AbstractAimsThis study aimed to investigate the postoperative urinary continence rate and incontinence types compared over time between conventional robot‐assisted radical prostatectomy (C‐RARP) and Retzius‐sparing RARP (RS‐RARP).MethodsAll 61 cases were selected from the C‐RARP and RS‐RARP by propensity score matching, and the pad scale, 24‐h pad weight test, and International consultation on incontinence questionnaire‐short form (ICIQ‐SF) were followed‐up over time up to 12 months.ResultsThe probability of urinary continence per pad scale evaluation differed according to how it was defined: the continence rate 12 months after C‐RARP and RS‐RARP were 94% and 95% for 1 pad/day, 85% and 92% for 1 security pad/day, 61% and 85% for no pad use, respectively, which were all significantly better with RS‐RARP. The results of the 24‐h pad weight test were significantly better with RS‐RARP at both 3 and 12 months, with median C‐RARP versus RS‐RARP values of 5 versus 1 g and 2 versus 0 g, respectively. In terms of types of urinary incontinence, the rates of postoperative stress urinary incontinence (SUI) increased in both procedures but to a lesser extent in RS‐RARP. Other types of urinary incontinence, such as urge incontinence and terminal dribbling, did not differ significantly before and after surgery and between the two procedures.ConclusionsPostoperative urinary continence was better with RS‐RARP than with C‐RARP per all follow‐up parameters until 12 months postoperatively. Postoperative SUI was significantly lower with RS‐RARP than with C‐RARP, which was considered the main reason for better postoperative urinary continence with RS‐RARP.
Germination temperature sensitivity differs between co‐occurring tree species and climate origins resulting in contrasting vulnerability to global warming
Authors: Filipe João C. , Ahrens Collin C. , Byrne Margaret , Hardy Giles , Rymer Paul D. 
Published: April 2023

AbstractClimate change is shifting temperatures from historical patterns, globally impacting forest composition and resilience. Seed germination is temperature‐sensitive, making the persistence of populations and colonization of available habitats vulnerable to warming. This study assessed germination response to temperature in foundation trees in south‐western Australia's Mediterranean‐type climate forests (Eucalyptus marginata (jarrah) and Corymbia calophylla (marri)) to estimate the thermal niche and vulnerability among populations. Seeds from the species' entire distribution were collected from 12 co‐occurring populations. Germination thermal niche was investigated using a thermal gradient plate (5–40°C). Five constant temperatures between 9 and 33°C were used to test how the germination niche (1) differs between species, (2) varies among populations, and (3) relates to the climate of origin. Germination response differed among species; jarrah had a lower optimal temperature and thermal limit than marri (To 15.3°C, 21.2°C; ED50 23.4°C, 31°C, respectively). The thermal limit for germination differed among populations within both species, yet only marri showed evidence for adaptation to thermal origins. While marri has the capacity for germination at higher thermal temperatures, jarrah is more vulnerable to global warming exceeding safety margins. This discrepancy is predicted to alter species distributions and forest composition in the future.
A conditional decomposition of proper scores: quantifying the sources of information in a forecast
Authors: Allen Sam , Ferro Christopher A. T. , Kwasniok Frank 
Published: April 2023

AbstractScoring rules condense all information regarding the performance of a probabilistic forecast into a single numerical value, providing a convenient framework with which to rank and compare competing prediction schemes objectively. Although scoring rules provide only a single measure of forecast accuracy, the expected score can be decomposed into components that each assess a distinct aspect of the forecast, such as its calibration or information content. Since these components could depend on several factors, it is useful to evaluate forecast performance under different circumstances; if a forecaster were able to identify situations in which their forecasts perform particularly poorly, then they could more easily develop their forecast strategy to account for these deficiencies. To help forecasters identify such situations, a novel decomposition of scores is introduced that quantifies conditional forecast biases, allowing for a more detailed examination of the sources of information in the forecast. From this, we claim that decompositions of proper scores provide a broad generalisation of the well‐known analysis of variance (ANOVA) framework. The new decomposition is applied to the Brier score, which is then used to evaluate forecasts that the daily maximum temperature will exceed a range of thresholds, issued by the Swiss Federal Office of Meteorology and Climatology (MeteoSwiss). We demonstrate how the additional information provided by this decomposition can be used to improve the performance of these forecasts, by identifying appropriate auxiliary information to include within statistical postprocessing methods.
Adenocarcinoma with mediastinal lymph node involvement developed from a pure ground grass nodule during 14 years
Authors: Miura Hiroyuki , Miura Jun , Goto Shinichi , Yamamoto Tomoko 
Published: April 2023

AbstractA 69‐year‐old female Japanese patient presented with an abnormal shadow on chest computed tomography (CT). She had received a mastectomy 14 years prior. Under the diagnosis of primary lung cancer, left upper lobectomy was conducted. Pathology showed a lepidic adenocarcinoma with mediastinal lymph node metastases with pT2aN2M0. Upon retrospective analysis, the chest CT at the time of mastectomy depicted a ground‐glass nodule (GGN) of less than 20 mm. Over the previous 10.5 years, the concentration of the central part of the GGN increased. Conclusively, a pure GGN developed into lung adenocarcinoma with mediastinal lymph node involvement over 14 years. She had bone metastases 4 years after the lobectomy but has survived for five and a half years after surgery with treatment with osimertinib. Comparison readings of films should be performed throughout the patient's clinical history to detect subtle shadow alterations indicative of tumour progression.
Digital approach toward environmental sustainability in supply chains: Evidence from Vietnamese firms
Authors: Nguyen Nha Minh , Hoai Tu Thanh , Vo Hien Van , Nguyen Nguyen Phong 
Published: April 2023

AbstractDespite substantial efforts to examine the factors driving green supply chain management practices and environmental performance in emerging markets, the roles of green digital learning orientation and digital transformation facilitating these practices are still not fully understood. Utilizing the resource‐based view strategy, we investigated how green digital learning orientation impacts environmental performance through green supply chain management practices, while also exploring the moderating effect of digital transformation in the green digital learning orientation and green supply chain management practices link. Our findings, based on data collected from 212 Vietnamese enterprises, indicate that green digital learning orientation has a positive impact on green supply chain management practices, which in turn leads to improved environmental performance. Additionally, the study reveals that digital transformation plays a significant moderating role in the relationship between green digital learning orientation and green supply chain management practices. These findings make a notable contribution to the existing digital transformation and sustainable supply chain literature. The study provides both theoretical and managerial implications, which are discussed in detail.
Theoretical Study of Azetidine Derivative by Quantum Chemical Methods, Molecular Docking and Molecular Dynamic Simulations
Authors: Sinha Prashasti , Yadav Anil Kumar 
Published: April 2023

AbstractAzetidine substituent group has a wide range of application in organic chemistry and medical field. In this study, a novel azetidine derivative and its reaction mechanism has been reported. Using quantum chemical method spectroscopic analysis and other parameters such as electronic and thermodynamic properties were studied to understand the physical as well as chemical behavior of the reported compound. Additionally, to study the antiviral activity, molecular docking studies were carried out against Hepatitis virus C (HCV) NS5B genotype and Norovirus as target protein. In order to validate the docking results molecular dynamic (MD) simulation and Molecular Mechanics‐Poisson‐Boltzmann Surface Area (MM‐PBSA) were calculated at 90 ns. The RMSD was obtained within the range 0.75 Å to 1.5 Å and binding energies (ΔGbind) for the two complexes was found to be −18.34 kJ/mol and −16.10 kJ/mol for each respective targets.It was found that reported compound can act as potential inhibitor for HCVand Norovirus.
A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles
Authors: Kumar S Lokesh , Servesh Anushka , Kumar Sriwastav Yash , Balasubramanian Sanjaybala , Tabassum Sumaiya , Govindaraju Santhosh 
Published: April 2023

AbstractMulticomponent reactions are crucial for operating organic synthesis. In today's world, chemists concentrate on greener methodologies that cater to rising environmental concerns. Most conventional organic solvents are harsh on the environment, which can be addressed by environmentally and pocket‐friendly Deep eutectic solvents (DES). Organic synthesis via MCR in the presence of DES has resulted in the blend of green methodology and green solvent for organic transformations. Forasmuch as addressing the environmental concerns and developing higher heterocycles, our review focuses on the literature published on the DES‐mediated Multicomponent synthesis of N‐Heterocyclic compounds.
Stratum‐Confined Solid‐State Reaction (SC‐SSR) toward Colloidal Silicon‐Based Hollow Nanostructures for Bioapplications
Authors: Choi Jeong Hun , Kumari Nitee , Kumar Amit , Acharya Anubhab , Ahn Jungsoo , Kim Jaerim , Hwang Hyeonwoong , Joo Taiha , Kim Jong Kyu , Lee In Su 
Published: April 2023

AbstractSilicon nanostructures (SiNSs) can provide multifaceted bioapplications; but preserving their subhundred nm size during high‐temperature silica‐to‐silicon conversion is the major bottleneck. The SC‐SSR utilizes an interior metal‐silicide stratum space at a predetermined radial distance inside silica nanosphere to guide the magnesiothermic reduction reaction (MTR)‐mediated synthesis of hollow and porous SiNSs. In depth mechanistic study explores solid‐to‐hollow transformation encompassing predefined radial boundary through the participation of metal‐silicide species directing the in‐situ formed Si‐phase accumulation within the narrow stratum. Evolving thin‐porous Si‐shell remains well protected by the in‐situ segregated MgO emerging as a protective cast against the heat‐induced deformation and interparticle sintering. Retrieved hydrophilic SiNSs (<100 nm) can be conveniently processed in different biomedia as colloidal solutions and endocytosized inside cells as photoluminescence (PL)‐based bioimaging probes. Inside the cell, rattle‐like SiNSs encapsulated with Pd nanocrystals can function as biorthogonal nanoreactors to catalyze intracellular synthesis of probe molecules through C‐C cross coupling reaction.
MXene and Carbon‐Based Electrodes of Thermocells for Continuous Thermal Energy Harvest
Authors: Liu Zhuoxin , Wei Shouhao , Hu Zhe , Zhu Minshen , Chen Guangming , Huang Yang 
Published: April 2023

AbstractLow‐grade heat represents a significant form of energy loss; thermocells (TECs) utilizing the thermogalvanic effect can convert thermal energy into electricity without generating vibrations, noise, or waste emissions, making them a promising energy conversion technology for efficiently harvesting low‐grade heat. Despite recent advancements, the reliance on high‐cost platinum electrodes in TECs has considerably hindered their widespread adoption. Developing cost‐effective electrodes that maintain the same thermoelectrochemical performance is crucial for the successful application of TECs. In this review article, the exploration of MXene materials as TEC electrodes is discussed first, emphasizing the immense potential of the MXene family for low‐grade heat harvesting applications. Next, recent research on carbon‐based electrodes is summarized, and morphological and structural optimizations are comprehensively discussed aiming at enhancing the thermoelectrochemical performance of TECs. In the concluding section, the challenges are outlined and future perspectives are offered, which provide valuable insights into the ongoing development of high‐performance TEC electrodes using MXene and carbon‐based materials.
In‐person versus online instruction: Evidence from principles of economics
Authors: Elzinga Kenneth G. , Harper Daniel Q. 
Published: April 2023

AbstractCOVID‐19 required many professors to switch from in‐person teaching to online instruction, allowing exploration of a pivotal question in education: are learning outcomes better when instruction takes place in‐person or online? We compare student performance across two semesters of the same large introductory economics course—one taught in‐person in 2019, the other taught online in 2020. We analyze test scores from over 2000 students for exam questions common to both instructional formats. At the aggregate level, we find no difference in student performance between online and in‐person instruction. When dividing questions by required reasoning skills, we find that online instruction improves student performance on questions requiring knowledge of a definition or formula. Additionally, student course evaluations rated the online course over in‐person pedagogy.
The challenge of inclusivity, capability and change in complex, multi‐stakeholder problem situations—Practical insight from the application of participative systems methods, models and facilitation within an organisational setting
Authors: Newsome Ian , Lloyd David 
Published: April 2023

AbstractReflecting on learning from the practical experience in the employment of systems thinking and facilitation to tackle complex, multi‐stakeholder problems in work settings, three interconnected challenges were commonly encountered: an inclusivity challenge, a capability challenge and a change challenge. A series of typical cases are outlined to help illustrate these challenges, where combinations of participative systems methods, models and facilitation practices were employed within complex, multi‐stakeholder policing problem situations.