bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mixed-Methods Approach for Evaluating Implementation Processes and Program Costs for a Hypertension Management Program Implemented in a Federally Qualified Health Center
Authors: Tucker-Brown Aisha , Spafford Michelle , Wittenborn John , Rein David , Marshall Ashley , Beasley Kincaid Lowe , Vaughan Marla , Nelson Natalie , Dougherty Michelle , Ahn Roy 
Published: June 2023

AbstractTeam-based care approaches are effective at improving hypertension control and have been used in clinical practice to improve hypertension outcomes. This study implemented and evaluated the Hypertension Management Program (HMP), which was originally developed in a high-resource health setting, in a health system with fewer resources and a patient population disproportionately affected by hypertension. Our objectives were to describe how a health system could adapt HMP to meet their needs and calculate total program costs. HMP uses a team-based, patient-centered approach involving clinical pharmacists who contribute to managing patients who have hypertension and ultimately preventing premature death due to uncontrolled hypertension. HMP has 10 components (e.g., EHR patient registries and outreach lists, no copayment walk-in blood pressure checks). Our project involved implementing the key components of HMP in a federally qualified health center (FQHC) in South Carolina. Adaptations from the key components of HMP were made to fit the participants’ settings. A mixed-methods evaluation assessed implementation processes, program costs, and implementation facilitators and barriers. From September 2018 to December 2019, clinical pharmacists conducted 758 hypertension management visits (HMVs) with 316 patients with hypertension. Total program costs for HMP were $325,532 overall and $16,277 per month. Monthly cost per patient was $3.62. The high engagement among clinical pharmacists, along with provider engagements, followed up by the subsequent referral of patients to HMP, facilitated the implementation process. Staff members observed improvements in hypertension control, which increased participation buy-in. Barriers included staff turnover, the perception among some providers that HMP took too much time, as well as perception of HMP as a pharmacy-specific initiative. A team-based, patient-centered approach to hypertension management can be adapted for FQHCs or similar settings that serve patient populations disproportionately affected by hypertension.
Underutilized Crocus Sativus L. Flowers: A Hidden Source of Sustainable High Value-Added Ingredients
Authors: Cerdá-Bernad Débora , Valero-Cases Estefanía , Pérez-Llamas Francisca , Pastor Joaquín Julián , Frutos María José 
Published: June 2023

AbstractCrocus sativus L. is used as a spice due to its organoleptic characteristics. Only flower stigmas are used for its production, as the rest of the flower is discarded as waste. This fact represents a lack of sustainability, since around 230,000 flowers are necessary to produce 1 kg of saffron. The main aim of this study was to contribute to the valorization of Crocus sativus L. spice and its floral by-products, through the study of their nutritional value and composition, in terms of hydrophilic and lipophilic compounds, as well as their functional properties. The results showed that saffron stigmas and floral bio-residues presented high contents of fiber, and the most abundant macronutrient were the carbohydrates, followed by proteins, and a low content in fats. All samples had high concentrations of glucose, fructose, lactic and malic acids, and minerals, mainly K, Ca and Mg. Furthermore, the polyunsaturated fatty acids were predominant, being linoleic acid (C18:2n6) the most abundant. Therefore, this research provides more in-depth information about the composition of saffron stigmas and floral by-products, to be considered as promising sources for the development of functional ingredients with new applications in the food industry.
Bullying in higher education: an endemic problem?
Authors: Tight Malcolm 
Published: June 2023

AbstractWe may think that bullying is a childish behaviour that is left behind on finishing school, or that universities and colleges are too cultured and intellectual as institutions to have room for such behaviour, but these hopes are far from the truth. The research evidence shows that bullying of all kinds is rife in higher education. Indeed, it seems likely that the peculiar nature of higher education actively encourages particular kinds of bullying. This article provides a review of the research on bullying in higher education, considering what this shows about its meaning, extent and nature, and reviews the issues that have been identified and possible solutions to them. It concludes that, while there is much that higher education institutions need to do to respond effectively to bullying, revisiting their traditions and underlying purposes should support them in doing so.
Towards Characterization of Skin Melanoma in the Clinic by Electron Paramagnetic Resonance (EPR) Spectroscopy and Imaging of Melanin
Authors: Wehbi Mohammad , Harkemanne Evelyne , Mignion Lionel , Joudiou Nicolas , Tromme Isabelle , Baurain Jean-François , Gallez Bernard 
Published: June 2023

AbstractThe incidence of melanoma is continuously increasing over time. Melanoma is the most aggressive skin cancer, significantly reducing quality of life and survival rates of patients at advanced stages. Therefore, early diagnosis remains the key to change the prognosis of patients with melanoma. In this context, advanced technologies are under evaluation to increase the accuracy of the diagnostic, to better characterize the lesions and visualize their possible invasiveness in the epidermis. Among the innovative methods, because melanin is paramagnetic, clinical low frequency electron paramagnetic resonance (EPR) that characterizes the melanin content in the lesion has the potential to be an adjunct diagnostic method of melanoma. In this review, we first summarize the challenges faced by dermatologists and oncologists in melanoma diagnostic and management. We also provide a historical perspective on melanin detection with a focus on EPR spectroscopy/imaging of melanomas. We describe key elements that allow EPR to move from in vitro studies to in vivo and finally to patients for melanoma studies. Finally, we provide a critical view on challenges to meet to make EPR operational in the clinic to characterize pigmented lesions.
Removal of mercury from water by phytoremediation process with Salvinia natans(L.) All.
Authors: Sitarska Magdalena , Traczewska Teodora , Hołtra Anna , Zamorska-Wojdyła Dorota , Filarowska Wiktoria , Hanus-Lorenz Beata 
Published: June 2023

AbstractMercury contamination from human activities is a severe environmental problem. The low cost of rhizofiltration of heavy metal-contaminated environments is causing an increasing interest in these technologies. The present study demonstrates the effectiveness of mercury removal from water by phytoremediation using S. natans. Plants cultured and collected from the environment were used. The study used Hoagland’s liquid medium contaminated with mercury: 0.15, 0.20, and 0.30. The bioconcentration factor obtained was 275–780. The relative growth rate was up to 0.12 g/gd and was much better for cultured plants than those collected from the environment. The removal rate of toxic metal was up to 94%. Total protein increased for cultures plants by up to 84%, while it decreased by up to 30% for those taken from the environment. Total chlorophyll for cultured plants decreased by up to 54%, which could be due to the toxic effect of the metal.
Calorie restriction mimetic drugs could favorably influence gut microbiota leading to lifespan extension
Authors: Shintani Tomoya , Shintani Hideya , Sato Masashi , Ashida Hisashi 
Published: June 2023

AbstractCalorie restriction (CR) can prolong human lifespan, but enforcing long-term CR is difficult. Thus, a drug that reproduces the effects of CR without CR is required. More than 10 drugs have been listed as CR mimetics (CRM), and some of which are conventionally categorized as upstream-type CRMs showing glycolytic inhibition, whereas the others are categorized as downstream-type CRMs that regulate or genetically modulate intracellular signaling proteins. Intriguingly, recent reports have revealed the beneficial effects of CRMs on the body such as improving the host body condition via intestinal bacteria and their metabolites. This beneficial effect of gut microbiota may lead to lifespan extension. Thus, CRMs may have a dual effect on longevity. However, no reports have collectively discussed them as CRMs; hence, our knowledge about CRM and its physiological effects on the host remains fragmentary. This study is the first to present and collectively discuss the accumulative evidence of CRMs improving the gut environments for healthy lifespan extension, after enumerating the latest scientific findings related to the gut microbiome and CR. The conclusion drawn from this discussion is that CRM may partially extend the lifespan through its effect on the gut microbiota. CRMs increase beneficial bacteria abundance by decreasing harmful bacteria rather than increasing the diversity of the microbiome. Thus, the effect of CRMs on the gut could be different from that of conventional prebiotics and seemed similar to that of next-generation prebiotics.
The role of emotions in human–nature connectedness within Mediterranean landscapes in Spain
Authors: Otamendi-Urroz Irene , Quintas-Soriano Cristina , Martín-López Berta , Expósito-Granados Mónica , Alba-Patiño Daniela , Rodríguez-Caballero Emilio , García-Llorente Marina , Castro Antonio J. 
Published: June 2023

AbstractLandscapes can lead to different emotions towards nature that in turn shape people’s environmental behavior and decision processes. This study explores the role of emotions that Mediterranean landscapes foster in people and to what extent these emotions are associated with human–nature connectedness (HNC). We conducted 176 face-to-face surveys to explore HNC and the diversity of emotions associated with a suite of landscapes in Southeast Spain. Results revealed that Marine and Coastal Protected Areas received the highest number of positive emotions, whereas Greenhouses and Non-Protected Littoral were linked to negative emotions. We propose a framework for classifying emotional landscapes according to four groups: emotionally positive, negative, polarized or neutral. Results showed that emotions might play a key role in shaping HNC in Spanish Mediterranean landscapes and may be used as a common ground for understanding roots underpinning human decisions and actions that lead to sustainable management or landscape degradation.
Disparities in the impacts of co-management on fishers’ livelihoods
Authors: Ruano-Chamorro Cristina , Gurney Georgina G. , Barnes Michele L. , Gelcich Stefan , Cinner Joshua E. 
Published: June 2023

AbstractNatural resources are widely managed through collaborative governance arrangements (e.g., co-management) which often result in the uneven distribution of costs and benefits among fishers. Discrepancies in how a fisher is impacted by co-management relative to other fishers or others in the community (i.e., disparity) can negatively affect fishers’ wellbeing, their support for management, and subsequently, ecological outcomes. Yet, disparities in the distribution of social impacts from co-management have rarely been assessed. We address this gap by examining disparities (losses and gains) in perceived livelihood impacts from co-management. Losses (or gains) occur when a fisher experiences a more negative (or positive) impact on their livelihood relative to other fishers or others in the community. We used data from interviews with 1191 fishers associated with 48 coral reef co-management arrangements across Kenya, Tanzania, Madagascar, Indonesia, and Papua New Guinea to examine how socioeconomic and institutional characteristics were associated with losses and gains from co-management. Overall, we found that more fishers perceived equality than disparities in the distribution of co-management impacts. Of those that perceived disparities, more fishers perceived losses than gains. We also found that disparities could be predicted by a range of socioeconomic characteristics, including distance to markets and wealth, and institutional characteristics of the co-management regime, such as gear, access, and area restrictions. This study provides insights on potential entry points that could be used by managers and policy-makers to promote equitable co-management of small-scale fisheries, such as the reduction of losses by increasing participation in decision-making processes, fostering conflict resolution mechanisms, prioritizing gear restrictions over area restrictions, and reducing poverty.
Beyond global versus local: illuminating a cosmolocal framework for convivial technology development
Authors: Kostakis Vasilis , Niaros Vasilis , Giotitsas Chris 
Published: June 2023

AbstractA reconceptualisation of technology, as a vital component of modern society cutting across all its other aspects, is required to achieve social and environmental sustainability. This paper presents a convivial technology development framework using the concept of “cosmolocal” production. The latter captures the dynamic of dispersed technology initiatives, which exhibit conceptualisations of living, working and making around the commons. It is a structural framework for organising production by prioritising socio-ecological well-being over corporate profits, over-production and excess consumption. From the vantage point of Tzoumakers, a cosmolocal initiative in which the authors participate, this paper offers an empirical account of its conception and evolution. We further examine its relation and cooperation with various similar interconnected places in urban and rural settings.
Pituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study
Authors: Hussein Ziad , Marcus Hani J. , Grieve Joan , Dorward Neil , Kosmin Michael , Fersht Naomi , Bouloux Pierre Marc , Jaunmuktane Zane , Baldeweg Stephanie E. 
Published: June 2023

Abstract
Background
Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function.

Objectives
To assess the incidence of hypopituitarism at presentation, the impact of treatment, and the likelihood of endocrine recovery during follow-up.

Methods
All patients treated surgically with and without radiotherapy for NFPMs between 1987 and 2018 who had longer than six months follow-up were identified. Demographics, presentation, investigation, treatment, and outcomes were collected.

Results
In total, 383 patients were identified. The median age was 57 years, with a median follow-up of 8 years. Preoperatively, 227 patients (227/375; 61%) had evidence of at least one pituitary deficiency. Anterior panhypopituitarism was more common in men (p = 0.001) and older patients (p = 0.005). Multiple hormone deficiencies were associated with large tumours (p = 0.03). Patients treated with surgery and radiotherapy had a higher incidence of all individual pituitary hormone deficiency, anterior panhypopituitarism, and significantly lower GH, ACTH, and TSH deficiencies free survival probability than those treated with surgery alone. Recovery of central hypogonadism, hypothyroidism, and anterior panhypopituitarism was also less likely to be reported in those treated with surgery and radiotherapy. Those with preoperative hypopituitarism had a higher risk of pituitary impairment at latest review than those presented with normal pituitary function (p = 0.001).

Conclusion
NFPMs are associated with a significant degree of hypopituitarism at time of diagnosis and post-therapy. The combination of surgery and radiotherapy is associated with a higher risk of pituitary dysfunction. Recovery of pituitary hormone deficit may occur after treatment. Patients should have regular ongoing endocrine evaluation post-treatment to assess changes in pituitary function and the need for long-term replacement therapy.
Lectotypification of names in Parkia R.Br. (Leguminosae: Caesalpinioideae, mimosoid clade) for Africa and Madagascar
Authors: Hopkins Helen C. F. 
Published: June 2023

SummaryTen specific names plus those of three varieties, which refer to the four currently recognised species of Parkia in Africa and Madagascar (P. bicolor A.Chev., P. biglobosa (Jacq.) R.Br. ex G.Don, P. filicoidea Welw. ex Oliv., P. madagascariensis R.Vig.), are listed. Their types are enumerated with lectotypes indicated where necessary and in a few cases, a second-step lectotypification is made. Two further names are invalid and illegitimate respectively. Two tables summarise the synonymy of these names according to major flora treatments and revisions of the genus. Connections between the botanist Robert Brown, who established the genus Parkia, and the explorer Mungo Park, after whom Brown named it, are described briefly.
TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models
Authors: Zhong Kun , Liu Xiaojun , Ding Weihua , Peng Lizhong , Zeng Xuhui , Gu Yayun 
Published: June 2023

AbstractTNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival, and carcinogenesis. The 13-cis-retinoic acid (RA), an active metabolite of vitamin A, exhibits anti-cancer properties, but the development of retinoic acid resistance poses a challenge in clinical application. This study aimed to investigate the relationship between TRAFs and retinoic acid sensitivity in various cancers. Here, we revealed that TRAFs’ expression varied significantly across The Cancer Genome Atlas (TCGA) cancer cohorts and human cancer cell lines. Additionally, inhibiting TRAF4, TRAF5, or TRAF6 improved retinoic acid sensitivity and reduced colony formation in ovarian cancer and melanoma cells. Mechanistically, knocking down TRAF4, TRAF5, or TRAF6 in retinoic acid-treated cancer cell lines increased the levels of procaspase 9 and induced cell apoptosis. Further in vivo studies using the SK-OV-3 and MeWo xenograft models confirmed the anti-tumor effects of TRAF knockdown combined with retinoic acid treatment. These findings support that combination therapy with retinoic acid and TRAF silencing may offer significant therapeutic advantages in treating melanoma and ovarian cancers.
Market system dynamics (MSD): A process-oriented review of the literature
Authors: Pedeliento Giuseppe , Mangiò Federico , Murtas Gabriele , Andreini Daniela 
Published: June 2023

AbstractThe renewed interest in the market as a unit of analysis has increased adoption of a market system dynamics (MSD) perspective. Since studies drawing on MSD have significant overlaps with other research traditions equally focused on market changes, we trace the theoretical boundaries of the literature on MSD, and unpack its evolution, in order to appreciate conceptual achievements and research directions. Building on change-process theorizing and on a reiterative processual multi-stage research strategy, we conduct a systematic review of the literature on MSD. We organize the findings into three stages of MSD’s maturation–infancy, adolescence, and adulthood–and show that MSD has grown into a market approach that is ever more multi-actor, theoretically-plural, and based on longitudinal methodologies. The existing literature has gradually shifted towards a balance in agency and structure in market change, and towards a more cautious view on the consumer’s role. Under-researched areas are pinpointed, along with research avenues that can further reinforce MSD.
Cognitive tuning in the STEM classroom: communication processes supporting children’s changing conceptions about data
Authors: Fry Kym , English Lyn , Makar Katie 
Published: June 2023

AbstractThe teaching and learning of statistical thinking begins at a young age in Australia, with a focus on data representation and interpretation from Foundation Year (age 5), and the collection, sorting and categorising of items from the natural environment starting even earlier. The intangible concept of data, as part of statistical literacy, can be complex for children to grasp, especially when applying the notion of data to the everyday world or when data are explored in isolation to an investigation process. Authentic data modelling experiences present meaningful opportunities to apply statistical thinking although expert STEM knowledge is not always accessible to primary classroom teachers, nor is it always obvious how to implement such authentic problems within a classroom context. In this exploratory case study, we present data from a Year 4 classroom (age 9) statistical investigation addressing, ‘How big is a leaf?’ linking data to the real-life STEM context they represented. The authors were interested in how the teacher’s communication processes supported her students’ emerging understandings about data. Wit’s (2018) cognitive tuning framework offered a way to capture how the communication processes in a group build to a commonly shared frame of reference. Findings revealed a pattern of communication between the teacher and students, supporting students’ changing conceptions of data and related statistical thinking processes, throughout the investigation.
Transcultural Aspects of Cannabis Use: a Descriptive Overview of Cannabis Use across Cultures
Authors: Rafei Parnian , Englund Amir , Lorenzetti Valentina , Elkholy Hussien , Potenza Marc N. , Baldacchino Alexander M. 
Published: June 2023

AbstractPurpose of ReviewThis narrative review summarises cultural aspects of cannabis use across different (sub)cultures, nations, and gender, racial, and ethnic groups. Specifically, we aimed to overview historical and traditional contexts of cannabis use and physical and mental health-related correlates, as well as emerging cannabis-related policies and their impacts on medicinal and recreational use of cannabis. In addition, we discuss how cultural factors may affect cannabis use behaviours and sociocultural underpinnings of cannabis use disorder trajectories.Recent FindingsCannabis is the most widely cultivated, trafficked, and used illicit drug worldwide, although cannabis is being legalised in many jurisdictions. More than 4% of individuals globally have used cannabis in the last year. Being traditionally used for religious and ritualistic purposes, today cannabis use is interwoven with, and influenced by, social, legal, economic, and cultural environments which often differ across countries and cultures. Notably, empirical data on distinct aspects of cannabis use are lacking in selected underrepresented countries, geographical regions, and minority groups.SummaryEmerging global policies and legislative frameworks related to cannabis use have impacted the prevalence and attitudes toward cannabis in different subcultures, but not all in the same way. Therefore, it remains to be elucidated how and why distinct cultures differ in terms of cannabis use. In order to understand complex and bidirectional relationships between cannabis use and cultures, we recommend the use of cross-cultural frameworks for the study of cannabis use and its consequences and to inform vulnerable people, clinical practitioners, and legislators from different world regions.