bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
Authors: Chen Xin-Yi , Wen Xiang-Mei , Zhao Wei , Chu Min-Qiang , Gu Yu , Huang Hai-Hui , Yuan Qian , Xu Zi-Jun , Qian Jun , Lin Jiang 
Published: February 2023

Abstract
Background
To identify the expression and methylation patterns of ALOX5AP in bone marrow (BM) samples of acute myeloid leukemia (AML) patients, and further explore its clinical significance.
Methods
Eighty-two de novo AML patients and 20 healthy donors were included in the study. Meanwhile, seven public datasets from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were included to confirm the alteration of ALOX5AP. Receiver operating characteristic (ROC) curve analysis was applied to determine the discriminative capacity of ALOX5AP expression to discriminate AML. The prognostic value of ALOX5AP was identified by the Kaplan-Meier method and log-rank test. It was further validated in four independent cohorts (n = 1186). Significantly different genes associated with ALOX5AP expression were subsequently compared by LinkedOmics, and Metascape database.
Results
The level of ALOX5AP expression was significantly increased in bone marrow cells of AML patients compared with healthy donors (P < 0.05). ROC curve analysis suggested that ALOX5AP expression might be a potential biomarker to discriminate AML from controls. ALOX5AP overexpression was associated with decreased overall survival (OS) in AML according to the TCGA data (P = 0.006), which was validated by other four independent cohorts. DNA methylation levels of ALOX5AP were significantly lower in AML patients compared to normal samples (P < 0.05), as confirmed in the Diseasemeth database and the independent cohort GSE63409. ALOX5AP level was positively associated with genes with proleukemic effects such as PAX2, HOX family, SOX11, H19, and microRNAs that act as oncogenes in leukemia, such as miR125b, miR-93, miR-494, miR-193b, while anti-leukemia-related genes and tumor suppressor microRNAs such as miR-582, miR-9 family and miR-205 were negatively correlated.
Conclusion
ALOX5AP overexpression, associated with its hypomethylation, predicts poorer prognosis in AML.
Experimental study on corner filling of B1800HS boron steel tubes in hot gas forming-quenching integrated process
Authors: Ruan Xianggang , Hu Xinyu , Xu Yi , Zhao Lidong , Cheng Chao , Han Fei , He Zhubin 
Published: February 2023

Abstract
The adequate filling and quenching of small corner features are major challenges in the hot gas forming-quenching integrated process to manufacture complex-shaped boron steel tubular parts. As the filling and quenching of small corners occurs at the later stages of pressurized bulging, the temperature of the non-contact zone on the tube may rapidly reduce below the required forming temperature. Considering the tube forming process involves closed and invisible features, a single-sided die quenching experiment for B1800HS boron steel sheets was designed to simulate the in-die quenching process of steel tubes. Moreover, the cooling rate and hardness distribution of the die-contact and non-contact zones were analyzed. Specific bulging experiments for variable diameter tubular parts with axial corner were performed. The effects of bulging temperature and pressurizing rate on corner filling, microstructure, and mechanical properties were studied. The results confirmed that for a given thickness of B1800HS sheet, regions of rapid cooling rate and martensite transformation occurred under a smaller diameter of the non-contact circular zone. For the sheet with a thickness of 1.4 mm, when the diameter of the non-contact circular zone was reduced to lower than 20 mm, the complete martensitic transformation of the entire sheet could be realized. For the boron steel tubes, the filling of the axial corner was significantly improved with the increase of the initial bulging temperature and the gas pressurizing rate. At the initial bulging temperature of 900 °C, when the pressurizing rate increased from 1 MPa/s to 3 MPa/s, the obtainable minimum corner radius decreased from 24 mm to 16 mm. The width of the non-contact zone was less than the diameter (15 mm) that can achieve complete martensitic transformation in the single-sided die quenching experiment; therefore, a sufficiently high cooling rate can be obtained. However, when the pressurizing rate increased from 3 MPa/s to 5 MPa/s, the obtainable minimum corner radius only decreased from 16 mm to 12 mm. The limited filling of the corner was the result of a significant temperature drop during hot gas forming. Decreasing the cooling rates of the tube or increasing the pressurizing rates during the hot forming stage can extend the range of reasonable process parameters in the hot gas forming-quenching integrated process of the boron steel tubes.
New congruences for broken k- diamond partitions
Authors: Yu Jing-Jun 
Published: February 2023

Abstract

Broken k-diamond partitions were introduced by Andrews and Paule. Let Δk(n) denote the number of broken k-diamond partitions of n. In 2015, By using the throey of Ramanujan’s theta function, Ahmed and Baruah established some congruences modulo 2 for Δ7(n). In this note, we continue to study the congruence properties of Δ7(n). By using the theory of modular forms, we generalize the congruences proved by Ahmed and Baruah. In addition, we also find two congruences modulo 2 for Δ23(n).
Terahertz Radiation Generation by Laser Interaction with a Periodic Array of GaAs Structure
Authors: . Sandeep , Malik Hitendra K 
Published: February 2023

Abstract
In the current study, a method for generating terahertz (THz) radiation using a GaAs structure array and transient current from a laser is proposed. The current generated across the length of these structures is responsible for the generation of THz radiation, where the entire system acts as phase-array dipole antennae. The maximum emitted THz power is achieved in the directions, where the conditions −bd/𝑐 𝑠𝑖𝑛𝜃𝑐𝑜𝑠𝜙=𝑝1𝜋 and −bd/𝑐 𝑠𝑖𝑛𝜃=𝑝2𝜋 are met; b and d are the widths and the length of a single GaAs structure and p1 and p2 are the integers. Where M1 and M2 are the numbers of GaAs structures along the longitudinal and transverse directions of the laser propagation, respectively, the overall antenna gain is observed to be M12 M22in these directions. The antennae approach used for the proposed GaAs periodic array enables us to obtain the THz profile in the frequency domain and realize the role of arrays and size of GaAs structure, making the emitted radiation suitable for its THz Time Domain Spectroscopic applications.
N-Formylation of Amines with CO 2 by Inorganic Ligand Support Ni Catalyst
Authors: Zhao Chengchun , Tao Chaofu , Xie Ya , Yu Han 
Published: February 2023

Abstract
N-formylation of amines with CO2 is a valuable approach to utilizing CO2 as a C1 source in organic synthesis. Herein we presented a highly efficient N-formylation of amines with CO2 and KBH4 catalyzed by (NH4)4[NiMo6O18(OH)6], which is composed of central Ni(II) core supported by MoVIO6 inorganic ligands, and provided corresponding formamides with good selectivity and yields for various primary and secondary amines under mild conditions. Moreover, primary diamines could also be efficiently formylated to afford diformamides. The catalyst could be recycled for six times without significant decrease in catalytic activity and used in gram-scale synthesis. Finally, the reaction mechanism was presented based on the related literature reports and control experiments.
pH-Responsive bio-erodible glipizide loaded PLA@GT-Dextran core-shell microspheres for antidiabetic drug delivery
Authors: Kumar Sumit , Bansal Smriti , Singh Ankita , Poddar Deepak , Sarkar Anjana 
Published: February 2023

Abstract
Hypoglycaemia and fast acting nature of glipizide makes it an effective antidiabetic drug but due to lack of sustainability of glipizide its usage is limited. Here, a pH responsive glipizide loaded PLA (poly (lactic acid)) microspheres were fabricated by emulsion solvent evaporation technique, which were coated with cationic derivative of dextran that exhibited significant pH sensitivity and mucoadhesive property due to presence of positively charged functional group that can readily interact with hydroxyl group present in the mucus lining via polar interaction. The fabricated core-shell microsphere possesses interconnected pores and constriction sites which control the release behavior of loaded glipizide and improve its efficiency. pH-responsive release behavior was evaluated by in-vitro drug release study at three distinct pH of 1.5, 7.4, and 9.2. The physiochemical characterization results confirmed that the glipizide was loaded within PLA microspheres and cationic dextran were present at its surface. The obtained core-shell microspheres possess an average particle size of 17.17 ± 1.33 µm with high drug encapsulation efficiency of 57.47 ± 2.7%. Due to presence of cationic dextran at microsphere`s surface, they possess high hydrophilicity as well as polar interaction with the mucus lining of stomach and also prevent premature release of drug in gastric media as indicated by contact angle measurement and confirmed by in-vitro release study at pH 1.5. A controlled glipizide release of 44.49 ± 11.01% was obtained at pH 9.2 within 48 hours.
A narrative inquiry into the cultivation of professional identity of medical students – through an online knowledge-sharing community
Authors: Li Shanshan 
Published: February 2023

Abstract
Cultivating medical talents with professional identity is the ultimate goal of medical education, yet there is a lack of long-term empiric data on the process of cultivation. This longitudinal narrative inquiry study collecting data from chat records, meetings and interviews involved a dynamic online knowledge-sharing community. Through focusing on the evolving characteristics of the online knowledge-sharing community and the changes in medical students’ dentities, this study utilized Clandinin and Huber’s framework to explore how students’ knowledge resonated with the group and developed in the online knowledge-sharing community, and during the process, how professional identity was cultivated in those pre-career years when professional growth opportunities were lacking. Fine-grained analysis showed that in a virtual community that overcame some barriers and formed multi-layered teacher-student relationships, medical students struggled to balance their self-identities and the professional identity by playing a proactive role and changing perspectives to share explicit and tacit knowledge, with blended interaction, facilitating strategies and the mentor’s role as influencing factors. The analysis also identified that the online knowledge-sharing community formed around originating events, with memories reconstuction and multi-layered interactions as the positive features of the way students engaged in online conversations to facilitate their professional identity. Online teacher-student knowledge-sharing communities provide an innovative approach to assisting professional identity formation. The study complements the literature about doctors’ online communities, knowledge sharing and the professional identity of medical students, and has important implications for medical education.
In-Situ Solar Tower Power Plant Optimization by
Differentiable Ray Tracing
Authors: Pargmann Max , Ebert Jan , Quinto Daniel Maldonado , Pitz-Paal Robert , Kesselheim Stefan 
Published: February 2023

Abstract

Solar tower power plants play a key role to facilitate the ongoing energy transition as they deliver
climate neutral electricity and direct heat for chemical processes. These plants generate temperatures
over 1000 °C by reflecting sunlight with thousands of mirrors (heliostats) to a receiver. The temper-
ature achievable in practice is limited due to the system’s susceptibility to small surface defects and
misalignments of individual mirrors, hindering the plant’s full efficiency. We present an inverse render-
ing technique that predicts the incident power distribution of each heliostat, including the inaccuracies,
based solely on focal spot images that are already acquired in most solar power plants. The method
allows reconstructing flawed mirror shapes within sub-mm precision. Applied at the solar tower plant in
Juelich, our approach outperforms all alternatives in accuracy and reliability. Our data-driven method
is a key ingredient to building digital twins of solar power plants. It can be integrated into the existing
infrastructure and plant control at low cost, leading to increased efficiency of existing and decreased
expenses for future power plants, the key factors of success in the competitive market. For other
fields, our approach can be a blueprint, as we present the option for the very first large-scale indus-
trial deployment of differentiable ray tracing. Merging data-intensive Machine Learning with physical
modeling creates flexible, data-efficient and trustworthy solutions applicable in science and industry.
Inhibiting Effect of Cationic Procyanidin Nanoparticles on Drug-Resistant Oral Squamous Cell Carcinoma Cell Lines
Authors: Yuan Xuewei , Li Kunshan , Lv Feifei , Li Na , Zhang Liru , Zhao Shuangling , Duan Yanhao , Qiu Yongle 
Published: February 2023

Background:
Multidrug resistance (MDR) is one of the primary causes of tumor chemotherapy
failure. Therefore, it is essential to uncover new drug treatment protocols. In the current study, employing
chitosan (CS) and sodium tripolyphosphate (TPP) as carriers and cross-linking agents, the proanthocyanidins
(PHL)/poly (lactic-co-glycolic acid) (PLGA) were encapsulated by emulsion solvent evaporation,
through which the cationic CS-PLGA-PHL nanosystem was obtained. The effectiveness of CS-PLGAPHL
on the invasion and migration of human oral squamous cell carcinoma cells was discussed, as were
their potential mechanisms.

Materials and Methods:
A CS-PLGA-PHL nanosystem was constructed by emulsion-solvent evaporation.
The size distribution, dispersion, and morphology were characterised by the laser particle size analyser
and transmission electron microscope. Human oral squamous cell carcinoma drug-resistant cell lines
SCC131/R and SCC-15/DDP were cultured in vitro. The two cell types were induced at different concentrations
by CS-PLGA-PHL, after which a CCK⁃8 experiment was performed to determine the effect of
CS-PLGA-PHL on the proliferation of the two cell lines. The 50% inhibitory concentration (IC50) of CSPLGA-
PHL was calculated at different time points. The transwell chamber experiment was performed to
identify the effects of CS-PLGA-PHL on the migration and invasion of OSCC cells. The expression levels
of MMP-2 and MMP-9 were detected by Western blot and q-PCR.

Results:
CS-PLGA-PHL is well dispersed. The PDI appeared to be lowest when the mass ratio of chitosan
to PLGA equaled 1:15. CS-PLGA-PHL exhibited a marked effect in inhibiting the proliferation of SCC-
131/R and SCC-15/DDP as well as the invasion and migration. CS-PLGA-PHL was able to downregulate
the expression of MMP-2 and MMP-9 genes and proteins significantly in drug-resistant cell lines.

Conclusion:
CS-PLGA-PHL for oral squamous cell carcinoma has been successfully prepared to exert
significant inhibition on the proliferation, invasion, and migration of OSCC cells. The mechanism involved
was possibly related to the down-regulation of MMP-2 and MMP-9 expression by CS-PLGA-PHL.
Is Magnetic Resonance Imaging (MRI) Still a Gold Standard to Detect
Breast Cancer: A Meta-analysis
Authors: Su Xiaochen , Wang Shaokai 
Published: February 2023

Purpose:
Breast cancer is fatal if it is not diagnosed and treated promptly; consequently,
early and precise diagnosis is essential. In comparison to mammography and sonography, the sensitivity
of MRI to cellular changes and its ability to differentiate benign from malignant tumors make it the
preferred imaging technique. Consequently, the present meta-analysis assessed the effectiveness of
different imaging modalities for breast cancer detection and evaluated the diagnostic accuracy of MRI.

Methods:
Pertinent articles were searched in PubMed, MEDLINE, and Central databases using the
appropriate keywords as per the PRISMA guidelines. Retrospective and prospective studies were included
according to the predefined PICOS criteria. A meta-analysis was performed using RevMan and
MedCalc software, and statistical parameters, such as odds ratio, sensitivity, specificity, likelihood
ratios, and accuracy, were calculated. Publication bias was evaluated using Egger’s and Begg’s tests,
and diagnostic performance was assessed using Youden’s and Bland-Altman's plots.

Results:
Fourteen clinical trials with 4666 breast cancer patients with perineural spread were included.
The included studies used MRI for the detection of breast cancer lesions according to the BI-RADS®
(Breast Imaging Reporting and Data System) guidelines and stated that it has high sensitivity and diagnostic
accuracy. Similarly, the present meta-analysis found a high sensitivity of 86.12 % and a high
diagnostic accuracy of 91.2%. Other than this, we obtained a specificity of 65%, a positive likelihood
ratio of 2.7, and a negative likelihood ratio of 0.22. The pooled odds ratio (OR) was reported to be 1.87
(95% CI 1.42-2.46), and the pooled risk ratio value was 1.19 (95% CI 1.11-1.28).

Conclusion:
Present meta-analysis strongly recommends MRI as an effective imaging method for the
detection of breast cancer.
YBX1, Targeted By Microrna-382-5p, Promotes Laryngeal Squamous Cell
Carcinoma Progression via Modulating RAS/MAPK Signaling
Authors: Zeng Wen , Pan Yiyun , Chen Hailong , Lei Xianhua , Zhang Xiangmin 
Published: February 2023

Background:
Laryngeal squamous cell carcinoma (LSCC) is the most common cancer
of head and neck cancer. Y-box binding protein-1 (YBX1) has tumor-promoting effects in some
types of cancers. However, its role in LSCC remains unknown. This study set out to identify the
role of YBX1 in LSCC.

Methods:
Bioinformatics analysis of the Gene Expression Omnibus (GEO) database and our cohort
data were used to explore the association of YBX1 expression with clinicopathological factors
in LSCC. Then, cells with stably or transiently transfected with plasmid or siRNA were constructed
to assess the effect of loss and gain of YBX1 on the biological phenotypes of LSCC cells
in vitro. In addition, subcutaneous xenograft and orthotopic liver tumor mouse models were constructed
for validation. The interrogated miRNA databases and subsequent luciferase reporter assays
were used to confirm the miR-382-5p target of YBX1. At last, KEGG enrichment annotation
from TGCA data was used for downstream analyses of miR-382-5p/YBX1 and verified by PCR
and Western immunoblotting.

Results:
The results showed that significant upregulation of YBX1 in LSCC tumors was correlated
with advanced TNM stage and poor prognosis. Knockdown of YBX1 markedly impaired the
proliferative, invasive, and migratory activity of Tu212 cells. We confirmed that miR-382-5p targets
YBX1 to mediate LSCC progression both in vitro and in vivo. We further confirmed that
miR-382-5p/YBX1 modulated the Ras/MAPK signaling axis to regulate the progression of LSCC.

Conclusion:
Together, our results indicated that YBX1 is an important promoter of LSCC progression.
And miR-382-5p/YBX1/RAS/MAPK signaling pathway can be perceived as a promising
target in the treatment of LSCC.
Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors
Authors: Baccalini Edoardo Andrea , Renne Salvatore Lorenzo , Colombo Piergiuseppe , Pasqualini Fabio , Quagliuolo Vittorio Lorenzo , Cananzi Ferdinando Carlo Maria , Grizzi Fabio , Borroni Elena Monica 
Published: February 2023

Background:
Desmoid tumors have an extremely variable natural history. The uncertainty behind desmoid
behavior reflects the complexity, which subtends its development and non-linear advancement. Apart from Wnt-
βcatenin mutation, estrogen receptors, and COX-2 overexpression, little is known about the ability of desmoids to grow
and recur while being unable to metastasize. Several tumors have been shown to express the CXCR4/CXCR7/CXCL12
axis, whose functions are essential for tumoral development.

Aims:
This study aimed to investigate the expression of the CXCR4/CXCR7/CXCL12 axis in primary desmoid tumors
and discuss the potential role of this key-signaling as an antiangiogenic therapeutic strategy.

Method:
In this study, 3 μm-thick consecutive sections from each formalin-fixed and paraffin-embedded tissue block
were treated with mouse monoclonal antibodies developed against CD34, CXCR4, CXCR7, and CXCL12.

Results:
Two distinct vessel populations: CXCR4+ and CXCR4- vessels, have been found. Similarly, chemokine receptor
CXCR7 expression in the entire desmoid tumor series positively stained a portion of tumor-associated vessels,
identifying two distinct subpopulations of vessels: CXCR7+ and CXCR7- vessels. All 8 neoplastic tissue samples expressed
CXCL12. Immunohistochemical positivity was identified in both stromal and endothelial vascular cells. Compared
to CXCR4 and CXCR7, the vast majority of tumor-associated vessels were found to express this chemokine.

Conclusion:
It is the first time, as per our knowledge, that CXCR4/CXCR7/CXCL12 axis expression has been identified
in a desmoid type-fibromatosis series. CXCL12 expression by neoplastic cells, together with CXCR4 and CXCR7
expression by a subgroup of tumor-associated vessels, was detected in all desmoid tumor tissue samples examined.
Since chemokines are known contributors to neovascularization, CXCR4/CXCR7/CXCL12 axis may play a role in
angiogenesis in this soft-tissue tumor histotype, thereby supporting its growth.
WITHDRAWN: Research on an Online Energy Acquisition Method of Transmission Line Based on Impedance Matching
Authors: Wenjun Bao , Min Ge , Zhikun Yuan , Xu He 
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

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