bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYL2 is a potential diagnostic, prognostic, and immune biomarker for HNSC
Authors: Duan Tingting , Hong Qichao , Ding Shun , Xu Zhengyang , Zhang Qimeng , Yan Jingren , Xing Chengliang 
Published: September 2023

Abstract
Purpose
MYL2, a potential biomarker, is aberrantly expressed in a variety of tumor tissues. The purpose of this study was to determine the exact involvement of MYL2 in HNSC.
Methods
Massive bioinformatics analysiswere used to assess MYL2 mRNA and protein expression levels and its functional role in HNSC. Next, the prognostic effect of MYL2 on HNSC was analyzed using TCGA and GEPIA. Afterwards, the effect of MYL2 on the immune microenvironment was examined by immune infiltration and monomolecular analysis. Finally, immunohistochemistry, western blot, RT-PCR, Plasmid transfection, Cell Migration and apoptosis assay were used to further confirm.
Results
MYL2 expression was considerably decreased in in HNSC tissues compared to normal tissues, according to TIMER and TGCA database analysis. Meanwhile, low MYL2 mRNA expression was associated with a greater clinical stage. In addition, this result was verified in nasopharyngeal carcinoma cell and tissue experiments. Subsequently, Kaplan-Meier survival analysis showed that low MYL2 expression was associated with better overall survival (OS). The results analyzed by ssGSEA with Spearman showed that MYL2 was positively correlated with most types of immune cells. Finally, MYL2 can inhibit the proliferation and migration of nasopharyngeal carcinoma cells, as well as promote apoptosis, according to the results of Plasmid transfection, Cell Migration and apoptosis assay.
Conclusion
The findings show that MYL2 influences the development of HNSC through the regulation of multiple immune cells. Therefore, MYL2 plays a crucial role in HNSC development and that it might be a potential independent prognostic biomarker and therapy target for HNSC.
An evolutionary case for plant rarity
Authors: Nytko Alivia , Senior John , Wooliver Rachel , O'Reilly-Wapstra Julianne , Schweitzer Jennifer , Bailey Joseph 
Published: September 2023

Abstract
Species rarity is a common phenomenon across global ecosystems that is becoming increasingly more common under climate change. Although species rarity is often considered to be a consequence of environmental or ecological constraints, we examined the hypothesis that plant rarity is a consequence of natural selection acting on performance traits that affect a species range size, habitat specificity, and population aggregation; three primary descriptors of rarity. Using a common garden of 25 species of Tasmanian Eucalyptus, we find that the rarest species have 53% lower biomass than common species. There is also a negative phylogenetic autocorrelation underlying the biomass of rare and common species, indicating that traits associated with rarity have diverged within clades as a result of environmental factors to reach different associated optima. In support of our hypothesis, we found significant positive relationships between species biomass, range size and habitat specificity, but not population aggregation. These results demonstrate repeated convergent evolution of the determinants of rarity across the phylogeny in the Tasmanian eucalypts. These results also suggest that if rarity can evolve and can potentially be related to plant traits such as biomass, rather than a random outcome of environmental constraints, we may need to revise conservation efforts in these and other rare species to reconsider the distributions of rare plant species and their ecosystem impacts.
An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics
Authors: Frey Brendan , Celaj Albi , Gao Alice , Lau Tammy , Holgersen Erle , Lo Alston , Lodaya Varun , Cole Christopher , Denroche Robert , Spickett Carl , Wagih Omar , Pinheiro Pedro , Vora Parth , Mohammadi-Shemirani Pedrum , Chan Steve , Nussbaum Zach , Zhang Xi , Zhu Helen , Ramamurthy Easwaran , Kanuparthi Bhargav , Iacocca Michael , Ly Diane , Kron Ken , Verby Marta , Cheung-Ong Kahlin , Shalev Zvi , Vaz Brandon , Bhargava Sakshi , Yusuf Farhan , Samuel Sharon , Alibai Sabriyeh , Baghestani Zahra , He Xinwen , Krastel Kirsten , Oladapo Oladipo , Mohan Amrudha , Shanavas Arathi , Bugno Magdalena , Bogojeski Jovanka , Schmitges Frank , Kim Carolyn , Grant Solomon , Jayaraman Rachana , Masud Tehmina , Deshwar Amit , Gandhi Shreshth 
Published: September 2023

Abstract

Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics. We describe a foundation model for RNA biology, “BigRNA”, which was trained on thousands of genome-matched datasets to predict tissue-specific RNA expression, splicing, microRNA sites, and RNA binding protein specificity from DNA sequence. Unlike approaches that are restricted to missense variants, BigRNA can identify pathogenic non-coding variant effects across diverse mechanisms, including polyadenylation, exon skipping and intron retention. BigRNA accurately predicted the effects of steric blocking oligonucleotides (SBOs) on increasing the expression of 4 out of 4 genes, and on splicing for 18 out of 18 exons across 14 genes, including those involved in Wilson disease and spinal muscular atrophy. We anticipate that BigRNA and foundation models like it will have widespread applications in the field of personalized RNA therapeutics.
Online Abuse of Politicians: Experimental Evidence on Politicians' own Perceptions
Authors: Pedersen Rasmus T. , Petersen Niels Bjørn Grund , Thau Mads 
Published: September 2023

Abstract

Criticism from dissatisfied citizens is an inevitable part of being an elected politician in a democracy. However, when negative feedback from citizens turns into outright abuse, this can have pernicious personal and democratic consequences. In this study, we therefore investigate how politicians perceive criticisms, insults, threats, and sexist remarks in social media comments. Based on a survey experiment with more than 700 politicians from the local, regional, and national levels, we show that politicians’ assessment of the abusiveness of negative messages are not only affected by the content of the messages but also by political ideology and gender. Left-leaning politicians find negative social media comments to be more abusive than right-leaning politicians do. In addition, politicians are more averse to negative comments targeting women than negative comments targeting men, and male politicians are generally less averse to negative comments than female politicians are. Somewhat surprisingly, politicians are generally not affected by in-party biases, as they exhibit similar levels of aversion towards negative messages directed at co-partisans and out-partisans. While previous research has focused on the extent to which politicians receive online abuse, few studies have examined how politicians perceive potentially abusive messages, and our study thus provides novel insights into what exactly politicians consider to be abusive behavior on social media.
Changes in central retinal and choroidal OCT/OCTA parameters following intravitreal bevacizumab injection in diabetic macular edema
Authors: Firouzabadi Mohammad Sadegh Dehghani , Farashah Shima Alsadat Dehghanpour , Manaviat Reza , Nouri Hosein , Abtahi Seyed-Hossein , Forouhari Ali 
Published: September 2023

Abstract
Background
To evaluate changes in central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and foveal vessel density (VD) in deep and superficial capillary plexuses (DCP and SCP) 30 days after intravitreal bevacizumab (IVB) injection in eyes with diabetic macular edema (DME).
Methods
A prospective observational study on 25 eyes of 25 patients who were candidates of intravitreal anti-VEGF injection for the treatment of DME was conducted. After conducting a comprehensive ophthalmic examination, using optical coherence tomography angiography (OCTA) and enhanced depth imaging OCT, we measured CMT, SFCT, and foveal VD in DCP and SCP. In addition, a blood sample was drawn from every patient to determine baseline hemoglobin A1c levels. One month after a single IVB injection, all the parameters were reassessed.
Results
Mean age of the included patients was 59.56 ± 9.74 years. One month following bevacizumab injection, mean CMT, SFCT, VD in superficial capillary plexus, and VD in deep capillary plexus layer significantly (P < 0.05) decreased by 10.03% ± 5.53%, 8.18% ± 3.39%, 3.06% ± 6.98%, 3.65% ± 6.41%, respectively. Best corrected visual acuity (BCVA; LogMAR) was also improved significantly. Patients with HbA1c level ≤ 7 at baseline showed a larger decrease in CMT (P = 0.02) with no significant difference in other parameters. The decrease in LogMAR BCVA after treatment showed a negative correlation with pre-treatment SFCT and a positive correlation with the decrease in foveal VD in SCP (rho = -0.42, P = 0.04, and rho = 0.44, P = 0.03, respectively). Spearman correlation analysis showed no significant association between the changes in CMT, SFCT, and VD in superficial or deep capillary plexuses. Patients with better anatomical response to the treatment (CMT reduction ≥ 10%) had significantly lower SFCT and higher CMT values at baseline.
Conclusions
Significant functional and anatomical improvements were evident one month after IVB injection in patients with DME. Better glycemic control could result in a significantly larger reduction in the CMT of eyes with DME. Anatomical improvements were not correlated with changes in other assessed variables. Thinner SFCT at baseline could be attributed to better functional and anatomical response in these patients.
Analysis of the impact of roughness coefficient changes due to land use changes on the hydraulics of the Kashafrood River
Authors: Nazarjani Mohammad , Saremi Ali , Eslami Ali Reza , Yazdani Vahid 
Published: September 2023

Abstract
Mashhad's Kashafrood basin has been affected by land use changes, urbanization, and the development of agricultural water resources. This basin is located in the Razavi Khorasan province, Mashhad city. This research analyzes the impact of land use changes on river flow from a hydraulic point of view. For this purpose, the studied area was divided into five sub-basins and flood values were calculated using Deacon's method and different return periods for the sub-basins. In order to determine the intensity and extent of lateral erosion, two factors, the height of the terraces (H) and the amount of erosion activity (T), were measured, separated into different classes and evaluated. Also, the river was simulated under different hydraulic regimes. The results showed that the effects of erosion in more than 50% of the observation path and the 25-year discharge entered the bed area. The highest sensitivity to changes in the roughness coefficient is related to the flow surface and the width of the upper surface. Based on this, this research provides valuable information for land use management, understanding the impact of land use changes on river basins, and for decision-making by the executives.
Electrolysis-induced hardness variation for quantitatively assessing the scaling tendency of circulating water
Authors: Zheng Guopeng , Wang Lida , Sun Wen , Yang Zhengqing , Bao Xuewei , Hao Anfeng , Deng Haitao , Li Hejin , Liu Guichang 
Published: September 2023

Abstract

The scaling problem exists universally in circulating water systems. Efficient and accurate assessment of scaling tendency is a prerequisite for solving the problem. In this work, it proposes electrolysis to induce hardness variation, which connects with the water stability evaluation index for quantitatively assessing the scaling tendency of water. The quantitative assessment is further realized on the basis of qualitative assessment. Then, the dynamic simulation experiments of circulating water are carried out to provide support for the electrolysis-induced hardness variation which clarifies the criteria that can meet the actual water requirements. This work can achieve an efficient and accurate quantitative assessment of the scaling tendency, which is of great significance for solving the scaling problem of circulating water systems.
Examining the open-source datasets for water quantity and quality using the soil and water assessment tool (SWAT)
Authors: Peker İsmail Bilal , Gülbaz Sezar 
Published: September 2023

AbstractWater quality modeling is very important for the management of water resources. In this study, the upper part of the Porsuk Basin in Türkiye is analyzed using SWAT. In the analysis, in addition to the data provided by the General Directorate of State Hydraulic Works (DSI), the freely available flow and water quality data from the GEMStat data portal were used. This study presents a discussion of the practicality of GEMStat data for a water quality model. For this purpose, firstly, the SWAT model was constructed with freely available global data sources on elevation, land use/land cover, and soil type. Then, the model flow outputs were calibrated and validated for both DSI and GEMStat data in three different time periods. As a result, the flow calibration and validation success in the daily time step is 0.64 and 0.44 according to the Nash–Sutcliffe efficiency (NSE). The model was also validated using GEMStat flow data and calibrated using GEMStat water quality data such as nitrate (NO3), total suspended solids (TSS), and dissolved oxygen (DO) with a reasonable value. Hence, the results showed that GEMStat flow and water quality data can be used as auxiliary open-source data in the modeling process.
Association of Prospective Falls in Older People With Ubiquitous Step-Based Fall Risk Parameters Calculated From Ambulatory Inertial Signals: Secondary Data Analysis
Authors: Al Abiad Nahime , van Schooten Kimberley S , Renaudin Valerie , Delbaere Kim , Robert Thomas 
Published: September 2023

Abstract

Background
In recent years, researchers have been advocating for the integration of ambulatory gait monitoring as a complementary approach to traditional fall risk assessments. However, current research relies on dedicated inertial sensors that are fixed on a specific body part. This limitation impacts the acceptance and adoption of such devices.

Objective
Our study objective is twofold: (1) to propose a set of step-based fall risk parameters that can be obtained independently of the sensor placement by using a ubiquitous step detection method and (2) to evaluate their association with prospective falls.

Methods
A reanalysis was conducted on the 1-week ambulatory inertial data from the StandingTall study, which was originally described by Delbaere et al. The data were from 301 community-dwelling older people and contained fall occurrences over a 12-month follow-up period. Using the ubiquitous and robust step detection method Smartstep, which is agnostic to sensor placement, a range of step-based fall risk parameters can be calculated based on walking bouts of 200 steps. These parameters are known to describe different dimensions of gait (ie, variability, complexity, intensity, and quantity). First, the correlation between parameters was studied. Then, the number of parameters was reduced through stepwise backward elimination. Finally, the association of parameters with prospective falls was assessed through a negative binomial regression model using the area under the curve metric.

Results
The built model had an area under the curve of 0.69, which is comparable to models exclusively built on fixed sensor placement. A higher fall risk was noted with higher gait variability (coefficient of variance of stride time), intensity (cadence), and quantity (number of steps) and lower gait complexity (sample entropy and fractal exponent).

Conclusions
These findings highlight the potential of our method for comprehensive and accurate fall risk assessments, independent of sensor placement. This approach has promising implications for ambulatory gait monitoring and fall risk monitoring using consumer-grade devices.
Cost of Illiquidity: Marketability and Liquidity Discounts in a Margrabe Exchange Option Framework
Authors: Abbott Ashok Bhardwaj 
Published: September 2023

ABSTRACT
Market declines of 2008–2009 and 2022–2023 brought renewed attention to the issue of illiquidity and the attendant costs faced by the stockholders. Margrabe exchange option-based models have been employed widely for estimating the cost of illiquidity (price risk). These models estimate the exchange ratio for two assets where the future price of both assets is unknown. Treating one of the assets as a numeraire, or currency in which the other asset is priced, simplifies the model and makes it easily tractable. Some authors have ignored this distinction, leading to inflated estimates for illiquidity discounts (sometimes exceeding 100 percent, a logical fallacy). In this paper, I present a uniform framework (the Margrabe exchange option) comparing the estimated cost of illiquidity under different information asymmetry assumptions. Empirical results presented are consistent with the theoretical predictions in that the expected rank order for estimated costs under different formulations is preserved.
JEL Classifications: C52; D47; D82; G13; K22.
Social innovation in waste management in residential buildings
Authors: Aligleri Lilian , Santos Doubek Lopes Camila , Lourenço Rodrigues Caio Victor , Pereira de Sampaio Cláudio 
Published: September 2023

A large number of Brazilian municipalities still need to develop models and arrangements that enhance the disposal and proper destination of materials, especially in homes at large residential buildings that increasingly occupy the metropolises and the urban landscape. Thus, from the theoretical perspective of social innovation, this paper presents a proposal for structuring multi-selective waste collection for residential condominiums that include the design of a multi-selective waste segregation system in the form of a Center, an environmental education program to stimulate new behaviors and separation habits of residents, and the structuring of new channels for the disposal of sorted materials. The construction of the model took place collaboratively, in a multi-stakeholder approach, including researchers from various areas of knowledge, cooperatives of waste pickers, and representatives of business associations constituted to fulfill the reverse logistics of materials, managers, and residents of residential condominiums. The social innovation presented proposes new dynamics and structures to improve logistics efficiency and the recovery of the economic value of the material, as well as the ability for the action of society and the socio-productive inclusion of waste pickers.
CHARACTERISTICS OF SUBJECTIVE ATTITUDES TOWARDS DISEASES IN MODERN ADOLESCENTS OF DIFFERENT GENDER IDENTITY
Authors: Ельникова Оксана Евгеньевна , Колосова Ирина Геннадьевна 
Published: September 2023

Статья посвящена изучению особенности субъективного отношения к болезни представителей современной молодежи с различной полоролевой, гендерной идентичностью. Представлены результаты диагностического исследования взаимосвязи полоролевой идентичности и типов отношения к болезни. В качестве методологической базы, рассматривается биопсихосоциальная модель, в рамках которой при характеристике состояния здоровья учитывает в первую очередь психологические факторы. Отмечается, что актуальные тенденции развития общества диктуют настоятельную необходимость рассмотрения таких понятий как «болезни» и «здоровья» в первую очередь не с физиологической точки зрения, но как некое психологическое состояние человека. Приводится анализ исследований, доказывающий, что носители разных гендерных ролей демонстрируют совершенно иные модели поведения в том числе и в сфере здоровьясбережения. Полученные экспериментальные результаты позволяют заключить, что модель поведения обусловлены полоролевой идентичностью и в ситуации отражения тех или иных симптомов болезни учет психологических характеристик личности, в частности, влияние субъективного отражение своего социального пола, при построении лечебного процесса болезни любой нозологии просто необходим.
This article examines how young people with different gender identities perceive disease and how their attitudes toward disease might be influenced by their gender roles. The study presents the results of a diagnostic analysis examining the relationship between gender identity and different ways of thinking about disease. The study draws on the biopsychosocial model, emphasizing psychological factors in health assessment. It is found that current trends in social development view the concepts of “disease” and “health” not only as physiological states but also as psychological states. The research analyzes studies showing that individuals with different gender roles have completely different behavioral patterns, including health protection. The experimental results obtained suggest that behavioral patterns are influenced by gender identity. When considering specific disease symptoms, it is essential to consider the individual’s psychological characteristics, especially the effects of his or her subjective perception of social gender. This consideration is very important in formulating the therapeutic approach to various disease conditions.
Sejarah Pakaian Adat Masyarakat Kajang Kabupaten Bulukumba (Studi Etnografi Komunikasi)
Authors: Ikram Ikramullah Mahdi , Mau Muliadi , Arianto Arianto 
Published: September 2023

This research was conducted in Tanah Toa Village, Kajang District, Bulukumba Regency, South Sulawesi, which until now still adheres to the beliefs of its ancestors, one of which is wearing all-black clothes which are considered sacred and sacred. This research method is descriptive qualitative and uses an ethnographic communication approach. Data was collected by means of observation, interviews, literature and documentation. The purpose of this study was to describe the history and traditions of the Ammatoa Kajang ethnic community's traditional clothing, Bulukumba Regency. The results of this research on the history and traditions of the Kajang tribe's traditional clothing are a marker of the cultural identity of the Ammatoa ethnic community, which illustrates the belief that humans are born from the realm of darkness until the end of their lives they also return to the realm of darkness. Carrying out the Ammatoa ancestral tradition as the highest customary leader who also used traditional clothing in the past, reflecting adherence to customary law (Pasang) especially the principle of attallasa' kamase-mase or living modestly/simplely, representing equality for everyone before God (Turiek Akra 'na), a sense of equality and a shared destiny.
Abstrak
Penelitian ini dilakukan di Desa Tanah Toa Kecamatan Kajang Kabupaten Bulukumba Sulawesi Selatan yang sampai saat ini masih memegang erat keperyaan para leluhurnya, salah satunya yaitu menggunakan pakain serba hitam yang dianggap sebagai pakaian yang suci dan sakral. Metode penelitian ini deskriptif kualitatif dan menggunakan pendekatan etnografi komunikasi. Data dikumpulkan dengan cara observasi, wawancara, kepustakaan dan dokumentasi. Tujuan penelitian ini untuk mendiskripsikan sejarah dan tradisi pakaian adat komunitas etnik Ammatoa Kajang Kabupaten Bulukumba. Hasil penelitian ini pada sejarah dan tradisi pada pakaian adat suku kajang merupakan penanda identitas kultural komunitas etnik Ammatoa, yang menggambarkan kepercayaan bahwa manusia terlahir dari alam kegelapan hingga akhir hayatnya juga kembali ke alam kegelapan. Melaksanakan tradisi leluhur Ammatoa sebagai pimpinan adat tertinggi yang juga menggunakan pakaian adat di masa lalu, mencerminkan ketaatan pada hukum adat (Pasang) khususnya prinsip attallasa’ kamase-mase atau hidup bersahaja/sederhana, merepresentasikan kesamaan derajat bagi setiap orang di depan tuhan (Turiek Akra’na), rasa persamaan dan senasib sepenanggungan.