bluuebunny/crossref_metadata_2025_split huggingface dataset:
EZH2‐mediated downregulation of miR‐155‐5p contributes to prostate cancer cell malignancy through SMAD2 and TAB2
Authors: Bai Zhi‐Jie , Liu Jia‐Yi , Xing Wen‐Zhou , Wang Hai‐Feng 
Published: January 2025

AbstractmiR‐155 exhibits variable expression in different tumors and fulfills diverse biological roles. However, specific molecular mechanisms by which miR‐155‐5p, which is under‐expressed in prostate cancer (PCa), operates are yet to be elucidated. The role of the enhancer of zeste 2 (EZH2)/miR‐155‐5p axis in PCa was determined by using bioinformatics tools and performing luciferase reporter assay, chromatin immunoprecipitation PCR, CCK‐8 assays, cell migration and invasion assays, RNA isolation, reverse transcription quantity (RT‐qPCR) and Western blot. miR‐155‐5p expression would be reduced and promoter methylation would increase in PCa. After 5‐Aza‐CdR treatment and the integration of the upstream promoter of miR‐155‐5p into a pGL3‐basic/luciferase construct, fluorescence reporter analysis showed that promoter hypermethylation mediated the suppression of miR‐155‐5p in PCa. Furthermore, EZH2 attached to the miR‐155‐5p promoter and modulated its expression. EZH2 facilitated the suppression of miR‐155‐5p through enhanced H3K27me3 methylation, considerably affecting its expression. Through dual‐luciferase assays, SMAD2 and TAB2 were confirmed as downstream targets of miR‐155‐5p, regulating the PCa cellular phenotype governed by miR‐155‐5p. Lastly, 5‐Aza‐CdR regulated miR‐155‐5p expression by modulating its promoter methylation and influenced the malignant behavior of PCa cells. EZH2 promotes H3K27me3 methylation, repressing miR‐155‐5p expression, which subsequently upregulates the downstream targets SMAD2 and TAB2 and promotes PCa cell proliferation, epithelial–mesenchymal transition (EMT), migration and invasion.
Multi‐Watt Long‐Wavelength Infrared Femtosecond Lasers and Resonant Enamel Ablation
Authors: Yang Xuemei , Zhang Dunxiang , Wang Weizhe , Tian Kan , He Linzhen , Guo Jinmiao , Hu Bo , Pu Tao , Li Wenlong , Sun Shiran , Ding Chunmei , Wu Han , Li Wenkai , Peng Yujie , Li Jianshu , Leng Yuxin , Liang Houkun 
Published: January 2025

AbstractHigh average power broadband tunable long‐wavelength infrared (LWIR) femtosecond lasers operating at fingerprint wavelengths of 7–14 µm hold significant promise across a range of applications, including molecular hyperspectral imaging, strong‐field light‐matter interaction, and resonant tissue ablation. Here, a 6–12 µm broadband tunable parametric amplifier based on LiGaS2 or BaGa4S7, generating an output power of 2.4 W at 7.5 µm, and 1.5 W at 9.5 µm, pumped by a simple and effective thin‐square‐rod Yb:YAG amplifier producing 110 W 274 fs output pulses is presented. As a proof of concept, efficient resonant ablation and microstructure fabrication on enamel are showcased at the hydroxyapatite resonant wavelength of 9.5 µm, with a laser intensity two orders‐of‐magnitude lower than that required by non‐resonant femtosecond lasers, which can foster more precision surgical applications with superior biosafety.
Significant Non‐Reciprocal Transmission Achieved by Combining Nonlinear Near‐Zero Index Materials with Bound States in the Continuum
Authors: Bi Dayu , Guo Zhiwei , Wang Qiang , Wei Qian , Wu Jiaju , Sun Yong , Chen Yuguang , Yang Yaping , Jiang Haitao , Chen Hong 
Published: January 2025

AbstractFor many modern photonics applications, significant nonlinear optical interactions are crucial. However, achieving this typically demands powerful laser sources and extended interaction area because most natural materials exhibit extremely weak optical nonlinearities. Hence, integrating nonlinear optics into novel nanophotonics devices poses a challenge. In this work, an asymmetrical optical nonlinear metasurface is proposed that combines effective zero‐index media with bound states in the continuum (BIC). This scheme enables us to achieve a huge non‐reciprocal intensity range of ≈7.1, leveraging significantly enhanced optical nonlinear effects. The high‐Q characteristics of quasi‐BIC within the zero‐index background greatly enhance light‐matter interactions and reduce operational power requirements. The non‐reciprocal metasurface relies on a straightforward set of material requirements and fabrication processes, making it a highly versatile option for various applications in optical communication, light detection, signal processing.
Mechanism of Carbon Steel Corrosion in Accelerated Corrosion Tests
Authors: Popova Kateryna , Prošek Tomáš 
Published: January 2025

ABSTRACTUnderstanding the effect of parameters of cyclic accelerated corrosion tests on the corrosion response is crucial for proper test design. The real‐time corrosion rate of carbon steel was measured using electrical resistance sensors in seven tests and was statistically evaluated. A synergistic effect of the chloride concentration and duration of transition phases was explained based on the surface electrolyte distribution. In contrast to the field, the steel corrosion rate increased between particular chloride deposition phases due to the formation of porous red rust with low protection ability. This implies that the corrosivity of future corrosion tests needs to be reduced.
Polymer‐Grafted Gold Colloids and Supracolloids: From Mechanisms of Formation to Dynamic Soft Matter
Authors: Rossner Christian 
Published: January 2025

AbstractGold nanoparticles represent nanosized colloidal entities with high relevance for both basic and applied research. When gold nanoparticles are functionalized with polymer‐molecule ligands, hybrid nanoparticles emerge whose interactions with the environment are controlled by the polymer coating layer: Colloidal stability and structure formation on the single particle level as well as at the supracolloidal scale can be enabled and engineered by tailoring the composition and architecture of this polymer coating. These possibilities in controlling structure formation may lead to synergistic and/or emergent functional properties of such hybrid colloidal systems. Eventually, the responsivity of the polymer coating to external triggers also enables the formation of hybrid supracolloidal systems with specific dynamic properties. This review provides an overview of fundamentals and recent developments in this vibrant domain of materials science.
RNF7‐Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes
Authors: Tao Yiran , Shi Zimin , Liang Xianyin , Zheng Yuqian , Dai Lirui , Li Xiang , Li Zian , Liang Wulong , Bai Gaojie , Li Hao , Lyu Yuan , Li Junqi , Zhang Tao , Hu Weihua , Zhou Shaolong , Shan Qiao , Fu Xudong , Wang Xinjun 
Published: January 2025

ABSTRACTRNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin‐RING‐type E3 ubiquitin ligases) and has been found to possess intrinsic anti‐ROS capabilities. Aberrant expression of RNF7 has been observed in various tumor types and is known to significantly influence tumor initiation and progression. However, the specific role of RNF7 in glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations, which induce metabolic reprogramming and result in notable heterogeneity among glioma with different IDH genotypes. Through analysis of public glioma databases, we identified a high expression of RNF7 in glioma and its correlation with patient prognosis. Moreover, we observed variations in RNF7 expression and its association with patient outcomes under different treatment modalities among different IDH genotypes. In this study, we demonstrated the critical role of RNF7 in the malignant phenotype of IDH1‐mutant glioma and its contribution to radiation resistance. Subsequent functional enrichment analysis of RNF7 in glioma, coupled with validation through cellular experiments, confirmed its significant involvement in maintaining redox balance. Our findings suggest that RNF7 exerts a buffering effect against radiation‐induced oxidative stress and counterbalances the redox stress induced by IDH1 mutation through its anti‐ROS activity. Additionally, our follow‐up investigations revealed that the upregulation of RNF7 after radiation exposure and in IDH1‐mutant glioma cells is induced by ROS. Collectively, our study underscores the potential of RNF7 as a molecular biomarker in glioma. Elevated RNF7 expression often indicates a heightened metabolic resilience in glioma, leading to resistance against radiotherapy.
Can Firms Favor Location Regulation?
Authors: Bui Dang‐Long 
Published: January 2025

ABSTRACTGovernment regulations are believed to confine targeted firms' economic power, leading to a decline (rise) in producer (consumer) surplus. This paper explores the implications of location regulation in a spatially discriminatory pricing model with homogeneous products and linear transportation costs. Contrary to conventional wisdom, location regulation benefits (harms) producers but harms (benefits) consumers when firms engage in quantity (price) competition. Next, under location regulation, Bertrand firms are less (more) dispersed than Cournot firms if the transport rate is high (low). I also extend the analysis by comparing location and price regulations, as well as considering product differentiation and quadratic transportation costs.
Formulation Optimization, Physicochemical Characterization, and Biocompatibility Assessment of Curcumin‐Loaded Aquasomes
Authors: Bwalya Fernando , Erdem Murat , Kaynak Mustafa Sinan 
Published: January 2025

ABSTRACTCurcumin, a polyphenolic compound with numerous health benefits, suffers from poor aqueous solubility and low bioavailability, limiting its therapeutic potential. This study aimed to characterize and enhance curcumin's bioavailability by aquasomes (AQ)—a novel drug delivery system comprising a core, a carbohydrate layer, and the drug. Using a central composite design within the response surface methodology, formulation parameters—core‐to‐coat ratio, incubation time, and drug amount—were optimized to achieve the desired particle size, polydispersity index (PDI), and zeta potential. Hydroxyapatite (HAP) cores were coated with various sugars (lactose, sucrose, maltose, and trehalose) and loaded with curcumin, then characterized by size, zeta potential, encapsulation efficiency, thermogravimetric analysis, and Fourier‐transform infrared spectroscopy (FTIR). The optimized HAP cores exhibited a particle size of 55.41 nm. Curcumin‐loaded AQ showed larger sizes, with sucrose and maltose formulations measuring 215.6 and 329.5 nm, respectively. Encapsulation efficiencies ranged from 50% to 55.1%, with trehalose‐coated AQ showing the highest efficiency. Drug release studies demonstrated a sustained release profile, with trehalose AQ achieving 90% release within 100 min. Stability assessments indicated no significant changes over 90 days, and photostability tests showed improved protection against light‐induced degradation. The study developed curcumin‐loaded AQ with enhanced stability and solubility, optimized through quality by design principles, offering a promising strategy to improve curcumin's bioavailability.
Residual Fatigue in Unipolar and Bipolar Depression: A Systematic Review
Authors: Pastuszak Michał , Cubała Wiesław Jerzy , Jakuszkowiak‐Wojten Katarzyna , Kwaśny Aleksander , Świeczkowski Damian , Gałuszko‐Węgielnik Maria 
Published: January 2025

ABSTRACTBackgroundResidual fatigue is a common and debilitating symptom in patients with unipolar and bipolar depression, even after achieving partial or full remission. It significantly impacts patients' quality of life and increases the risk of relapse. This systematic review aims to evaluate the prevalence and effectiveness of therapeutic options for residual fatigue in individuals with unipolar major depressive disorder (MDD) and bipolar disorder (BD).MethodsA comprehensive search was conducted in the PubMed, SCOPUS, and Web of Science databases up to September 2024. The protocol for this systematic review was registered in PROSPERO. The search strategy included terms related to depression and residual fatigue. Studies were included if they provided data on adult patients diagnosed with MDD or BD, and if they measured the prevalence or treatment of residual fatigue. Risk of bias was assessed using the Cochrane Risk of Bias tool for randomized controlled trials (RCTs) and the Newcastle–Ottawa Scale for non‐randomized studies.ResultsTwenty studies were included in the review. The vast majority reported on MDD, and single papers investigated BD. Residual fatigue was reported by up to 83% of patients, and moderate to severe residual fatigue affected a smaller percentage. Pharmacological treatments, such as modafinil and to a lesser extent atomoxetine, demonstrated short‐term reductions in residual fatigue.ConclusionResidual fatigue remains a significant challenge in the treatment of depression, persisting in a large portion of patients despite remission. Pharmacological interventions like modafinil appear promising, but more research is needed, especially in BD. Standardized assessment tools and longer‐term studies are essential to better understand and treat residual fatigue.Trial RegistrationPROSPERO identifier: CRD42024543087
Front Cover Image
Authors: Friuli Marco , Lia Riccardo Paolo , Nitti Paola , Lamanna Leonardo , Otranto Domenico , Pombi Marco , Demitri Christian , Cafarchia Claudia 
Published: January 2025

The cover image is based on the article Beauveria bassiana associated with a novel biomimetic hydrogel to control Aedes albopictus through lure and kill ovitraps by Marco Friuli et al., https://doi.org/10.1002/ps.8476.
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A Review of Selected Alternative Remediation Methods for PFAS Contamination
Authors: Örnhem Gal A. Olivia , Åström Mats E. , Filipsson Monika E. M. 
Published: January 2025

ABSTRACTThere are numerous per‐ and polyfluoroalkyl substances (PFAS)‐contaminated areas worldwide, with aqueous film‐forming foams (AFFFs) frequently representing a significant contaminant source. This research reviews nine remediation methods and their efficacy and suitability under different environmental conditions and various PFAS. The evaluation included the remediation methods' suitability for soil or water remediation; in situ or ex situ use; effectiveness for different PFAS; cost‐effectiveness; regenerative capabilities; susceptibility to organic material, other substances, or pH; potential for PFAS‐concentrated waste production; and past use in large‐scale remediation projects. The study concludes that the methods have varying advantages and disadvantages, depending, for example, on the specific PFAS that require remediation and the type of media such as soil or water.
Adaptive Fault‐Tolerant Control of High‐Order Nonlinear Delay Systems Under Unknown Dead‐Zone Fault and Unknown Control Coefficients and Its Application
Authors: Deng Xiongfeng , Guo Li , Li Runze 
Published: January 2025

ABSTRACTThis work addresses the fault‐tolerant control (FTC) problem of the high‐order nonlinear systems (HONSs). The HONSs under study are jointly affected by the unknown time delays, unknown asymmetric dead‐zone fault, and unknown control coefficients. Based on the designed Lyapunov‐Krasovskii functional (LKF), the unknown time‐delay nonlinear terms of the system are effectively compensated. Through the introduction of suitable Nussbaum gain function (NGF), the issue stemming from unknown control coefficients is solved. Meanwhile, the approximation problem of unknown nonlinear dynamics is effectively tackled based on the application of radial basis function neural network (RBFNN). Furthermore, a NN‐based adaptive fault‐tolerant tracking control scheme is developed and adaptive control laws for some unknown parameters are formulated. The key feature of this control scheme is to ensure that the tracking error asymptotically converges to a small neighborhood of zero, while keeping all signals of the closed‐loop system are semi‐globally uniformly and ultimately bounded (SGUUB). Ultimately, the validity of the controller proposed in this work is testified through given examples.
Well‐Defined PtCo@Pt Core‐Shell Nanodendrite Electrocatalyst for Highly Durable Oxygen Reduction Reaction
Authors: Yin Shixin , Song Yiting , Liu Heng , Cui Jialin , Liu Zhongliang , Li Yu , Xue Tianrui , Tang Weizheng , Zhang Di , Li Hao , Li Huihui , Li Chunzhong 
Published: January 2025

AbstractThe rational design of efficient electrocatalysts with controllable structure and composition is crucial for enhancing the lifetime and cost‐effectiveness of oxygen reduction reaction (ORR). PtCo nanocrystals have gained attention due to their exceptional activity, yet suffer from stability issues in acidic media. Herein, an active and highly stable electrocatalyst is developed, namely 3D Pt7Co3@Pt core‐shell nanodendrites (NDs), which are formed through the self‐assembly of small Pt nanoparticles (≈6 nm). This unique structure significantly improves the ORR with an enhanced mass activity (MA) of 0.54 A mgPt−1, surpassing that of the commercial Pt/C (com‐Pt/C) catalyst by three fold (0.17 A mgPt−1). The well‐organized dendritic morphology, along with the Pt‐rich shell, contributes significantly to the observed high catalytic activity and superior stability for acidic ORR, which exhibit a loss of 2.1% in MA and, impressively, an increase of 12.0% in specific activity (SA) after an accelerated durability test (ADT) of 40,000 potential‐scanning cycles. This work offers insights for improving the design of highly stable Pt‐based electrocatalysts for acidic ORR.
Skin‐Inspired and Self‐Powered Piezoionic Sensors for Smart Wearable Applications
Authors: Yu Xinpeng , Zhang Xiaohong , Lu Chao 
Published: January 2025

AbstractBio‐inspired by tactile function of human skin, piezoionic skin sensors recognize strain and stress through converting mechanical stimulus into electrical signals based on ion transfer. However, ion transfer inside sensors is significantly restricted by the lack of hierarchical structure of electrode materials, and then impedes practical application. Here, a durable nanocomposite electrode is developed based on carbon nanotubes and graphene, and integrated into piezoionic sensors for smart wearable applications, such as facial expression and exercise posture recognitions. The nanocomposite electrode provides abundant channels for ion transfer because of its hierarchically porous structure. Carbon nanotubes not only prevent restacking of graphene nanolayers, but also connect them across out‐plane dimension. The piezoionic skin sensors present a high degree of linearity in a wide strain range with high sensitivity, and long cycling life with bending strains beyond 20 000 s. Further, a smart bracelet based on flexible sensors is fabricated for accurate posture recognition of badminton exercise, valuable to athlete training.
Integration of machine learning and genome‐wide association study to explore the genomic prediction accuracy of agronomic trait in oats (Avena sativa L.)
Authors: Peng Jinghan , Lei Xiong , Liu Tianqi , Xiong Yi , Wu Jiqiang , Xiong Yanli , You Minghong , Zhao Junming , Zhang Jian , Ma Xiao 
Published: January 2025

AbstractMachine learning (ML) has garnered significant attention for its potential to enhance the accuracy of genomic predictions (GPs) in various economic crops with the use of complete genomic information. Genome‐wide association studies (GWAS) are widely used to pinpoint trait‐related causal variant loci in genomes. However, the simultaneous integration of both methods for crop genome prediction necessitates further research. In this study, we integrated ML and GWAS to assess the efficiency of GP for seven key agronomic traits in 195 oat (Avena sativa) cultivars from major oat‐growing regions around the world. A total of 94 trait‐associated single nucleotide polymorphisms were identified through the GWAS study. GP studies were conducted using the classical model genomic best linear unbiased prediction (GBLUP) and six ML models. GBLUP performed poorly in predicting all traits except flag leaf width, while none of the ML models consistently provided the best prediction accuracy across all traits. The prediction accuracy of the GWAS‐derived markers was better than that of the use of genome‐wide markers, and plant height had the highest prediction rate at 100 GWAS‐derived markers, and the rest of the traits for which more markers were required. These results play an important role in advancing the use of GP in small oat breeding programs by optimizing the prediction rate of GP and reducing the number of markers, confirming that high prediction rates can be achieved with smaller datasets.
Implant-based reconstruction and adjuvant radiotherapy in breast cancer patients—current status and DEGRO recommendations
Authors: Piroth M. D. , Krug D. , Baumann R. , Strnad V. , Borm K. , Combs S. , Corradini S. , Duma M. N. , Dunst J. , Fastner G. , Feyer P. , Fietkau R. , Harms W. , Hehr T. , Hörner-Rieber J. , Matuschek C. , Schmeel C. , Budach W. ,   Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Published: January 2025

Abstract
Purpose
The aim of this review is to give an overview of the results of prospective and retrospective studies using allogenic reconstruction and postmastectomy radiotherapy (PMRT) in breast cancer and to make recommendations regarding this interdisciplinary approach.

Materials and methods
A PubMed search was conducted to extract relevant articles from 2000 to 2024. The search was performed using the following terms: (breast cancer) AND (reconstruction OR implant OR expander) AND (radiotherapy OR radiation). Data from the literature on allogenic breast reconstruction and radiation are presented and discussed in relation to toxicity and cosmesis.

Conclusion and recommendations
Breast reconstruction is also feasible if PMRT is necessary. Patients need to be informed about the relevant risk of capsular fibrosis and implant failure. A planned reconstruction is no reason to forgo PMRT nor is an indication for PMRT a reason to forego implant-based breast reconstruction if desired by the patient. It is important to provide detailed information here to enable shared decision-making. There is still no clear consensus regarding implant-based reconstruction (IBR) and PMRT. However, in clinical practice, both a one-stage (immediate “implant-direct” IBR) procedure with PMRT up to the final implant and a two-stage (immediate-delayed IBR) procedure with PMRT up to the tissue expander (TE) and later exchange of the TE are used; both approaches have their specific advantages and disadvantages. Depending on patient-specific factors and the surgeon’s experience and estimates, both IBR procedures are also possible in combination with PMRT. When using a TE/implant approach, completing skin stretching by adequately filling the expander before PMRT may be favorable. This approach is particularly practical when adjuvant chemotherapy is planned but may lead to postponement of radiotherapy when primary systemic therapy is given. According to the latest data, moderate hypofractionation also appears to be safe in the context of the IBR approach. It is important to have a closely coordinated interdisciplinary approach and to fully inform patients about the increased rate of potential side effects.