bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Cycloplegia on the Biometer for Optical Low-coherence Reflectometry
Authors: Yakar Konuralp 
Published: January 2023

Abstract
Purpose The aim of this study was to compare the biometric measurements and different formulas for calculating intraocular lens (IOL) power by using the Lenstar LS900 biometer for optical low-coherence reflectometry before and after induction of cycloplegia in the adult population.
Materials and Methods In this cross-sectional study, 168 eyes of 168 healthy volunteers aged 40 – 86 years (59.22 ± 11.57) were included. Biometric measurements, including axial length (AL), anterior chamber depth (ACD), keratometry (K1 and K2), and white-to-white (WTW) were compared using a Lenstar LS900 optical biometer before and after induction of cycloplegia with 1% cyclopentolate. The IOL power was also compared using six different formulas (Barrett Universal II, Haigis, SRK/T, Hoffer Q, Holladay, and SRK-II) for the AcrySof MA60AC IOL before and after induction of cycloplegia.
Results There were no statistically significant differences in AL, K1 and K2, or WTW measurements before and after induction of cycloplegia. There was a significant increase only in ACD from the biometric parameters after the induction of cycloplegia (p < 0.05). Despite this change, there were no significant changes in IOL power calculations using the six different formulas before and after induction of cycloplegia.
Conclusions This study demonstrated that IOL power measurements using the Lenstar LS900 can be performed after cycloplegia.
Iodine-Catalyzed One-Pot Multicomponent Synthesis of Pyrrolo/indolo[1,2-a]quinoxalines Substituted with ortho-Carbonyl Alkyl Benzoates/Benzoic Acids via Spirocyclic Ring Opening
Authors: Raghunadh Akula , Simhachalam Gorle , Rao L. Vaikunta , Samsonu Dasi 
Published: January 2023

AbstractAn efficient iodine-catalyzed cascade coupling protocol was developed for the synthesis of tetracyclic and pentacyclic pyrrolo[1,2-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives via the iodine-mediated oxidative Pictet–Spengler reaction of 2-(1H-pyrrol-1-yl)aniline or 2-(1H-indol-1-yl)aniline with ninhydrin followed by spirocyclic ring opening with alcohol/water. The target compounds were obtained in good-to-excellent yields with a broad substrate scope.
A Comparative Evaluation of Malocclusion and Associated Risk Factors in Patients Suffering with Temporomandibular Disorders: A Systematic Review and Meta-analysis of Observational Studies
Authors: Trivedi Anshul , Agarwal Saumya , Gupta Ishita , Goswami Roma , Mowar Apoorva 
Published: January 2023

AbstractAn association of malocclusion as potent risk factor to temporomandibular disorders (TMDs) has been under question since ages. A systematic review and meta-analysis of case–control and cohort studies was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses)guidelines to compare the prevalence of TMDs in subjects with malocclusion to patients with normocclusion. The study was registered on the PROSPERO database (identifier: CRD42022315863). An elaborate electronic database (PubMed, DOAJ, and Google Scholar) and manual search resulted in 325 articles, among which 7 and 3 articles were shortlisted for qualitative and quantitative review, respectively, for articles published from January 2000 until December 2021. A total of 4,183 participants were included in this review with age range of 5 to 75 years. New–Castle Ottawa tool was employed for quality assessment, while I 2 statistical value for meta-analysis was interpreted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Fixed effect model was applied as, I 2 = 0. Pooled odds ratio with 95% confidence interval for all three studies was 14.64 [4.43, 48.36] suggesting that TMDs were 14.64 times more associated in patients with malocclusion (cases) than patients without malocclusion (controls). Within the limitations and fair quality of evidence of the current review and analysis, TMDs and associated symptoms are more prevalent in patients with malocclusion with or without more associated factors.
Physicochemical, volatile compounds, oxidative and sensory profiles of the Longissimus muscle of six South African sheep breeds
Authors: Olagbegi Bosede R. , Chikwanha Obert C. , Katiyatiya Chenaimoyo L. F. , Marais Jeannine , Molotsi Annelin H. , Dzama Kennedy , Mapiye Cletos 
Published: January 2023

Context The scarcity of water and feed for sheep is a characteristic feature in the dryland areas of South Africa, and adversely affects meat production and quality. To address this challenge, breeds with high water, feed and production efficiencies must be used to produce meat of desirable quality. Aim The study aimed to compare physicochemical, volatile compounds, oxidative and sensory profiles of the Longissimus muscle from selected South African sheep breeds raised under intensive feeding conditions. Methods Physicochemical, oxidative, volatile compounds and sensory profiles of the Longissimus muscle from lambs of indigenous (Damara, n = 10; Pedi, n = 8), indigenous composite (Dorper, n = 10; Meatmaster, n = 9) and exotic composite (Dohne Merino, n = 10; South African Merino, n = 10) breeds that were penned individually and fed a lamb-finishing diet ad libitum over a 42-day test period were evaluated. Results Dohne Merino had the highest intramuscular fat content, whereas Damara and Pedi had the lowest (P ≤ 0.05). Meat lightness increased over time, with Pedi having the highest values on Day 7 of retail display at 4°C, followed by the Merinos (P ≤ 0.05). On Day 7, meat from the Merinos had the highest lipid oxidation values, whereas Damara and Pedi had the lowest (P ≤ 0.05). The lowest meat protein oxidation values on Day 7 were recorded for the Meatmaster, followed by Dohne Merino (P ≤ 0.05). Relative to the other breeds, Dohne Merino had the greatest concentrations of alcohols, aldehydes and acidic volatile compounds, and the lowest concentrations of esters (P ≤ 0.05). In addition, the Merinos had meat that was slightly more tender and juicy (P ≤ 0.05) than that of Damara and Dorper. Conclusions Even though indigenous breeds produced meat with comparable oxidative shelf-life and sensory quality attributes to composite breeds under intensive feeding conditions, they had leaner meat than the later breeds. Implications The observed variations in meat physicochemical and oxidative shelf-life parameters allow producers to select breeds that are best suited to their production systems, resources and market requirements.
Calibration of angle standards
Authors: Gastaldi B , Vieira L , Yshikawa F Huerta , Faust B , Eves B 
Published: January 2023

Main text
Optical polygons and angle gauge blocks are the primary artifacts for disseminating the unit of angle to industry. The Consulative Committee for Length (CCL) has designated the calibration of such angle artifacts as a key comparison topic area in order to ensure world-wide traceability and equivalence of angle measurements at the lowest measurement uncertainties. This report describes the key comparison in the topic area of angle metrology for the SIM region. An optical polygon and six angle gauge blocks were measured by five national metrology institutes (NMI). The comparison was successful and the results of the participants are reported. One NMI reported values that were initially inconsistent with the key comparison reference value for the optical polygon.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Local recovery of a piecewise constant anisotropic conductivity in EIT on domains with exposed corners
Authors: de Hoop Maarten V , Furuya Takashi , Lin Ching-Lung , Nakamura Gen , Vashisth Manmohan 
Published: January 2023

Abstract
We study the local recovery of an unknown piecewise constant anisotropic conductivity in electric impedance tomography on certain bounded Lipschitz domains Ω in

R

2

with corners. The measurement is conducted on a connected open subset of the boundary

∂
Ω

of Ω containing corners and is given as a localized Neumann-to-Dirichlet map. The above unknown conductivity is defined via a decomposition of Ω into polygonal cells. Specifically, we consider a parallelogram-based decomposition and a trapezoid-based decomposition. We assume that the decomposition is known, but the conductivity on each cell is unknown. We prove that the local recovery is almost surely true near a known piecewise constant anisotropic conductivity γ
0. We do so by proving that the injectivity of the Fréchet derivative

F

′

(

γ
0

)

of the forward map F, say, at γ
0 is almost surely true. The proof presented, here, involves defining different classes of decompositions for γ
0 and a perturbation or contrast H in a proper way so that we can find in the interior of a cell for γ
0 exposed single or double corners of a cell of suppH for the former decomposition and latter decomposition, respectively. Then, by adapting the usual proof near such corners, we establish the aforementioned injectivity.
Comparison of a hybrid model and experimental measurements for a dielectric-coated coaxial ECR thruster
Authors: Sánchez-Villar Álvaro , Boni Federico , Désangles Victor , Jarrige Julien , Packan Denis , Ahedo Eduardo , Merino Mario 
Published: January 2023

Abstract
Electrostatic probe and thrust balance measurements of a coaxial electron-cyclotron-resonance plasma thruster with magnetic nozzle are compared against numerical simulations of the device that solve self-consistently the plasma transport problem with a hybrid particle-in-cell/fluid approach and the microwave electromagnetic fields using mixed finite elements. A simple phenomenological anomalous transport model similar to those used in Hall thruster modeling is applied. Reasonable average relative errors are reported on the ion current density (8.7%) and plasma density (12.8%) profiles along the plume. Good agreement is found in terms of relative errors on thruster performance parameters as the 90%-current divergence angle (0%–3%), utilization efficiency (3%–10%), peak ion energy (9%–15%), and energy efficiency (2%–17%). The comparison suggests that enhanced cross-field diffusion is present in the plasma. Differences in the experimental and numerical behavior of electron temperature point to the areas of the model that could be improved. These include the electron heat flux closure relation, which must correctly account for the axial electron cooling observed.
Non-Gaussian displacement distributions in models of heterogeneous active particle dynamics
Authors: Lemaitre Elisabeth , Sokolov Igor M , Metzler Ralf , Chechkin Aleksei V 
Published: January 2023

Abstract
We study the effect of randomly distributed diffusivities and speeds in two models for active particle dynamics with active and passive fluctuations. We demonstrate how non-Gaussian displacement distributions emerge in these models in the long time limit, including Cauchy-type and exponential (Laplace) shapes. Notably the asymptotic behaviours of such Cauchy shapes are universal and do not depend on the precise diffusivity distributions. Moreover, the resulting shapes of the displacement distributions with distributed diffusivities for the active models considered here are in striking contrast to passive diffusion models. For the active motion models our discussion points out the differences between active- and passive-noise. Specifically, we demonstrate that the case with active-noise is in nice agreement with measured data for the displacement distribution of social amoeba.
Refractive index sensing performance demonstration of reflective microfiber long taper elaborated by silver and silicon nanoparticles using seawater samples
Authors: Dang Hongtao , Wang Jianfeng , Wang Dewen , Li Jin 
Published: January 2023

Abstract
A refractive index fiber probe has been proposed based on a long-tapered microfiber, which was obtained from a long single-mode microfiber by the oxyhydrogen-flame-scanning and stretching method using a multifunctional fiber tapering machine. This microfiber probe was used to detect the refractive index of seawater samples with different concentrations by demodulating the intensity of reflected light. The refractive index sensing performance of the long-tapered microfibers elaborated by the low refractive index UV glue distributing silver nanoparticles and silicon nanoparticles were experimentally demonstrated, compared and analyzed. More stable spectra and sensing performance was obtained for the silicon nanoparticles compared to that of silver nanoparticles. Although a high average refractive index sensitivity of 13.047 dBm R−1IU−1 was obtained for the long-tapered microfiber coated by two layers of silver nanoparticle UV films. However, the quality of the corresponding spectra was severely damaged, and the amplitude of light intensity at different wavelengths varied greatly. These problems can be well avoided for the silicon nanoparticle-decorated microfiber tapers, where the overall monotonic variation of the interference spectral intensity will greatly simplify the signal demodulation process and improve the reliability of the measurement results.
Constraining disformal couplings with Redshift Space Distortion
Authors: Dusoye Avishek , de la Cruz-Dombriz Álvaro , Dunsby Peter , Nunes Nelson J. 
Published: January 2023

Abstract
We study a quintessence model for which the scalar field is disformally coupled to dark matter. The background mimics the ΛCDM cosmological evolution and the quintessence potential is not specified. A disformal effect due to the quintessential mass is seen in the growth rate of the cosmological structure on large scales. The disformal parameter renders no appreciable effect on the evolution of the total matter perturbation. An analysis of the conformal parameter and quintessential mass is investigated using the Redshift Space Distortion data to find the best-fit values that might explain the well-known σ
8 tension.
Artificial neural network-based rapid predictor of biological nerve fiber activation for DBS applications
Authors: Golabek Justin , Schiefer Matthew , Wong Joshua K , Saxena Shreya , Patrick Erin 
Published: January 2023

Abstract

Objective. Computational models are powerful tools that can enable the optimization of deep brain stimulation (DBS). To enhance the clinical practicality of these models, their computational expense and required technical expertise must be minimized. An important aspect of DBS models is the prediction of neural activation in response to electrical stimulation. Existing rapid predictors of activation simplify implementation and reduce prediction runtime, but at the expense of accuracy. We sought to address this issue by leveraging the speed and generalization abilities of artificial neural networks (ANNs) to create a novel predictor of neural fiber activation in response to DBS. Approach. We developed six variations of an ANN-based predictor to predict the response of individual, myelinated axons to extracellular electrical stimulation. ANNs were trained using datasets generated from a finite-element model of an implanted DBS system together with multi-compartment cable models of axons. We evaluated the ANN-based predictors using three white matter pathways derived from group-averaged connectome data within a patient-specific tissue conductivity field, comparing both predicted stimulus activation thresholds and pathway recruitment across a clinically relevant range of stimulus amplitudes and pulse widths. Main results. The top-performing ANN could predict the thresholds of axons with a mean absolute error (MAE) of 0.037 V, and pathway recruitment with an MAE of 0.079%, across all parameters. The ANNs reduced the time required to predict the thresholds of 288 axons by four to five orders of magnitude when compared to multi-compartment cable models. Significance. We demonstrated that ANNs can be fast, accurate, and robust predictors of neural activation in response to DBS.
Nonparametric identification of random coefficients in aggregate demand models for differentiated products
Authors: Dunker Fabian , Hoderlein Stefan , Kaido Hiroaki 
Published: January 2023

Summary
This paper studies nonparametric identification in market-level demand models for differentiated products with heterogeneous consumers. We consider a general class of models that allows for the individual-specific coefficients to vary continuously across the population and give conditions under which the density of these coefficients, and hence also functionals such as the fractions of individuals who benefit from a counterfactual intervention, is identified.
Dissection of theCaenorhabditis elegans Microprocessor
Authors: Nguyen Thuy Linh , Nguyen Trung Duc , Ngo Minh Khoa , Nguyen Tuan Anh 
Published: January 2023

AbstractMicroprocessor (MP) is a complex involved in initiating the biogenesis of microRNAs (miRNAs) by cleaving primary microRNAs (pri-miRNAs). miRNAs are small single-stranded RNAs that play a key role in the post-transcriptional regulation of gene expression. Thus, understanding the molecular mechanism of MP is critical for interpreting the roles of miRNAs in normal cellular processes and during the onset of various diseases. MP comprises a ribonuclease enzyme, DROSHA, and a dimeric RNA-binding protein, which is called DGCR8 in humans and Pasha in Caenorhabditis elegans. DROSHA cleaves stem-loop structures located within pri-miRNAs to generate pre-miRNAs. Although the molecular mechanism of human MP (hMP; hDROSHA-DGCR8) is well understood, that of Caenorhabditis elegans MP (cMP; cDrosha-Pasha) is still largely unknown. Here, we reveal the molecular mechanism of cMP and show that it is distinct from that of hMP. We demonstrate that cDrosha and Pasha measure ∼16 and ∼25 bp along a pri-miRNA stem, respectively, and they work together to determine the site of cMP cleavage in pri-miRNAs. We also demonstrate the molecular basis for their substrate measurement. Thus, our findings reveal a previously unknown molecular mechanism of cMP; demonstrate the differences between the mechanisms of hMP and cMP; and provide a foundation for revealing the mechanisms regulating miRNA expression in different animal species.
Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence
Authors: Cross Andrew L , Hawkes Jenny , Frankland Helen , Mediana Ayren , Wright Helen L , Goodson Nicola J , Edwards Steven W , Moots Robert J 
Published: January 2023

Abstract

Objectives
Identifying that dysfunction of the IL-23/17 axis underlies PsA has led to the development of effective targeted therapies such as the IL-17A inhibitor secukinumab. As IL-17A stimulates the secretion of neutrophil chemoattractants, such as CXCL8 (IL-8), we examined the effect of secukinumab on neutrophil function in PsA.

Methods
Nineteen patients with active PsA were treated with secukinumab. Clinical response [PsA Response Criteria (PsARC) and Psoriasis Area and Severity Index (PASI)] and peripheral blood neutrophil function (apoptosis, receptor expression, phagocytosis/killing, chemotaxis and RNA expression) were measured at 12 week intervals for 48 weeks and compared with age- and sex-matched healthy controls.

Results
At 12 weeks, 12/16 (75%) patients had a PsARC response (100% at 36 weeks) and 10/14 (71%) achieved a 90% PASI response. At baseline, there were no differences in PsA neutrophil reactive oxygen species generation, constitutive or cytokine-delayed apoptosis, chemotaxis or phagocytosis of opsonized Staphylococcus aureus compared with healthy controls. Similarly, there were no differences in these functions from baseline to 12 weeks of therapy. However, surface levels of CD11b/CD18 and CD63 increased and expression of CD16 decreased during therapy. In addition, in a subgroup of early (12 week) responders to secukinumab, RNA sequencing revealed transcriptome changes predicting down-regulation of cytokine signalling and chemotaxis pathways and up-regulation of de novo gene expression pathways, including translation initiation, mRNA catabolism and translation.

Conclusion
Complex changes in the properties of circulating neutrophils occur with secukinumab treatment in PsA that may indicate altered responsiveness to changes in both local and systemic levels of pro-inflammatory cytokines. However, host defence processes of neutrophils were unaltered.
Education Value Units in Medical Education: A Scoping Review
Authors: Gottlieb Michael , Regan Linda , Jordan Jaime , Westrick Jennifer , Bailitz John 
Published: January 2023

Purpose
On the basis of the tripartite mission of patient care, research, and education, a need has arisen to better support faculty in non-revenue-generating activities, such as education. As a result, some programs have developed education value unit (EVU) systems to incentivize these activities. The purpose of this scoping review is to analyze the existing literature on EVUs to identify current structures and future directions for research.

Method
The authors conducted a literature search of 5 databases without restrictions, searching for any articles on EVU systems published from database inception to January 12, 2022. Two authors independently screened articles for inclusion. Two authors independently extracted data and all authors performed quantitative and qualitative synthesis, consistent with best practice recommendations for scoping reviews.

Results
Fifty-eight articles were included. The most common rationale was to incentivize activities prioritized by the department or institution. Of those reporting funding, departmental revenue was most common. The majority of EVU systems were created using a dedicated committee, although composition of the committees varied. Stakeholder engagement was a key component for EVU system development. Most EVU systems also included noneducational activities, such as clinical activities, scholarship activities, administrative or leadership activities, and citizenship. Incentive models varied widely but typically involved numeric- or time-based quantification. EVUs were generally seen as positive, having increased equity and transparency as well as a positive impact on departmental metrics.

Conclusions
This scoping review summarizes the existing literature on EVU systems, providing valuable insights for application to practice and areas for future research.
The current status of immunotherapy in the treatment of primary advanced and recurrent endometrial cancer
Authors: Fontenot Virginia E. , Tewari Krishnansu 
Published: January 2023

Purpose of review
Despite the recent upward trends in incidence and mortality of endometrial cancer, there are still limited FDA-approved therapies for patients with primary advanced and recurrent endometrial cancer. This disparity presents the opportunity for further investigation of targeted therapies in this patient population.

Recent findings
One such area of adjuvant therapy is immunotherapy, which has shown improved progression-free survival in patients with several solid tumors, including endometrial, leading to the FDA approval of two immune checkpoint inhibitors. Additionally, with further study of precision medicine, the current adjuvant treatment paradigms that exist based on histopathologic subtype alone may be shifting towards a new genomic-based approach.

Summary
This article is a snapshot of the origins of immunotherapy use in this patient population as well as a guide to its future use. The author's hope with this article is to describe the patient population as well as the history of the integration of immunotherapy use into the adjuvant treatment of endometrial cancer leading up to FDA approval of Pembrolizumab and Dostarlimab. This article also consolidates the current literature as well as ongoing clinical trials that will hopefully lead to FDA approval of more immunotherapeutic agents in the near future.