bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Overview of Hibiscus rosa-sinensis L.: Its Ethnobotanical Uses, Phytochemistry, Therapeutic Uses, Pharmacological Activities, and Toxicology
Authors: Amtaghri Smail , Qabouche Adil , Slaoui Miloudia , Eddouks Mohamed 
Published: May 2023

Abstract:
Hibiscus rosa-sinensis (H. rosa-sinensis) has been largely used in traditional medicine. This study aims to review the pharmacological and phytochemical properties of Hibiscus rosa-sinensis L and also summarize the pharmacological, photochemical, and toxicological characteristics of H. rosa-sinensis. The current review focuses on the distribution, chemical content, and main uses of H. rosa-sinensis. Various scientific databases, including ScienceDirect, Scopus, PubMed, Google Scholar, etc., were used. Correct plant names were verified from plantlist.org. The results were interpreted, analyzed, and documented based on bibliographic information. This plant has been frequently used in conventional medicine due to its high concentration of phytochemicals. All its parts contain numerous chemical compounds, such as flavonoids, tannins, terpenoids, anthocyanins, saponins, cyclopeptide alkaloids, and vitamins. More interestingly, the roots of this plant contain glycosides, tannins, phytosterols, fixed oils, fats, flavonoids, saponins, gums, and mucilages. The leaves contain alkaloids, glycosides, reducing sugars, fat, resin, and sterols. The stem contains other chemical compounds, such as ß-sitosterol, teraxeryl acetate, cyclic sterculic, and malvalic acids. Finally, the flowers contain riboflavin, thiamine, apigenidine, oxalic acid, citric acid, quercetin, niacin, pelargonidine, and ascorbic acid. This species has a wide variety of pharmacological applications, such as antimicrobial, antioxidant, antidiabetic, anti-inflammatory, antihypertensive, antifertility, antifungal, anticancer, hair growth-promoting, antihyperlipidemic, reproductive, neurobehavioral, antidepressant, and antipyretic activities. Finally, toxicological studies have shown that higher doses of extracts from the plant are safe.
Therapeutic Application of Pineapple: A Review
Authors: Kumar Virender , Garg Vandana , Dureja Harish 
Published: May 2023

Background:
Ananas comosus L. (family Bromeliaceae) is a plant innate to South
America and has been cultivated in various world regions. The plant parts have traditionally been
used to treat various ailments, like cancer, diabetes mellitus, bacterial infection, Covid-19 infection,
inflammation, arthritis, asthma, malaria, cardiovascular disease, and burn, as debridement
agents. The pineapple contains nutrients, including vitamin C, iron, potassium, and protein. It also
contains flavonoids, carotenoids, tannins, polyphenols, and alkaloids.

Methods:
An extensive literature search was conducted on Ananas comosus using three scientific
databases: PubMed, Scopus, and Web of Science. The keywords in this paper were combined
to form a search strategy. Ananas comosus and pineapple were the main criteria for
judging abstracts, titles, and keywords. In the full text of the paper, the secondary judgment
criteria included mentioning "therapeutic potential" or "pharmacological activities”. Among
the 250 references in the compiled bibliography, there were original articles, books, and web
addresses dating back to 2001 to 2023. A review of articles was conducted after abstracts and
titles were screened, and 61 duplicate articles were deleted. In this paper, information is provided
on the therapeutic potential and pharmacological actions of Ananas comosus and its bioactive
compounds.

Results:
In this review, the therapeutic potential of A. comosus has been detailed. The current review
intends to provide an updated comprehensive overview of the versatile plant's use and its
clinical trials.

Conclusion:
The plant has gained enormous attention and increasing consideration for treating
various diseases. The therapeutic potential of pineapple, its compound, extracts, and their mode
of action are discussed briefly. Also, clinical trials are emphasized, which are in great demand
and need further in-depth investigation in the future.
The Impact of Point-of-Care Testing for Influenza on Antimicrobial Stewardship (PIAMS) in UK Primary Care: Protocol for a Mixed Methods Study
Authors: Hoang Uy , Williams Alice , Smylie Jessica , Aspden Carole , Button Elizabeth , Macartney Jack , Okusi Cecilia , Byford Rachel , Ferreira Filipa , Leston Meredith , Xie Charis Xuan , Joy Mark , Marsden Gemma , Clark Tristan , de Lusignan Simon 
Published: May 2023

Background
Molecular point-of-care testing (POCT) used in primary care can inform whether a patient presenting with an acute respiratory infection has influenza. A confirmed clinical diagnosis, particularly early in the disease, could inform better antimicrobial stewardship. Social distancing and lockdowns during the COVID-19 pandemic have disturbed previous patterns of influenza infections in 2021. However, data from samples taken in the last quarter of 2022 suggest that influenza represents 36% of sentinel network positive virology, compared with 24% for respiratory syncytial virus. Problems with integration into the clinical workflow is a known barrier to incorporating technology into routine care.

Objective
This study aims to report the impact of POCT for influenza on antimicrobial prescribing in primary care. We will additionally describe severe outcomes of infection (hospitalization and mortality) and how POCT is integrated into primary care workflows.

Methods
The impact of POCT for influenza on antimicrobial stewardship (PIAMS) in UK primary care is an observational study being conducted between December 2022 and May 2023 and involving 10 practices that contribute data to the English sentinel network. Up to 1000 people who present to participating practices with respiratory symptoms will be swabbed and tested with a rapid molecular POCT analyzer in the practice. Antimicrobial prescribing and other study outcomes will be collected by linking information from the POCT analyzer with data from the patient’s computerized medical record. We will collect data on how POCT is incorporated into practice using data flow diagrams, unified modeling language use case diagrams, and Business Process Modeling Notation.

Results
We will present the crude and adjusted odds of antimicrobial prescribing (all antibiotics and antivirals) given a POCT diagnosis of influenza, stratifying by whether individuals have a respiratory or other relevant diagnosis (eg, bronchiectasis). We will also present the rates of hospital referrals and deaths related to influenza infection in PIAMS study practices compared with a set of matched practices in the sentinel network and the rest of the network. We will describe any difference in implementation models in terms of staff involved and workflow.

Conclusions
This study will generate data on the impact of POCT testing for influenza in primary care as well as help to inform about the feasibility of incorporating POCT into primary care workflows. It will inform the design of future larger studies about the effectiveness and cost-effectiveness of POCT to improve antimicrobial stewardship and any impact on severe outcomes.

International Registered Report Identifier (IRRID)
DERR1-10.2196/46938
On Childism
Authors: McGillivray Anne 
Published: May 2023

Childism is prejudice against children. Its cognates include racism and sexism. ‘Childism’ was coined in 1975 but childism has existed since Roman times. This essay considers the origin and meaning of childism, the importance of retaining its meaning as prejudice, the origins of the prejudice itself, and the ways in which it is expressed. The context is rights advocacy by children. The aim is to assist children’s advocacy for rights and full personhood – the realization of rights – by understanding the fact and nature of childism.
Uji Keefektifan Lembar Kerja Peserta Didik Berorientasi Higher Order Thinking Skills Pada Materi Evolusi Kelas XII di SMA Negeri 4 Wajo
Authors: Nurdin Nurhidaya , Adnan Adnan , Muis Abd. 
Published: May 2023

The purpose of this study is to find out the effectiveness of hots-oriented Student Worksheets (LKPD) that have been developed. This research is development research with reference to the ADDIE development model. This research was carried out at SMA Negeri 4 Wajo with a research sample, namely 30 students of class XII MIPA Collaboration. Based on the results of the study, it can be stated that the HOTS-oriented LKPD developed is effective, it can be seen from the number of students who achieved the KKM value of 25 people with a percentage classically of 83.33% so that it was declared effective.
Key words: effective, LKPD, HOTS, Evolution

ABSTRAK
Tujuan dari penelitian ini adalah untuk mengetahui keefektifan Lembar Kerja Peserta Didik (LKPD) berorientasi HOTS yang telah dikembangkan. Penelitian ini merupakan penelitian pengembangan dengan mengacu pada model pengembangan ADDIE. Penelitian ini dilaksanakan di SMA Negeri 4 Wajo dengan sampel penelitian yaitu peserta didik kelas XII MIPA Kolaborasi sebanyak 30 orang. Berdasarkan hasil penelitian maka dapat dinyatakan bahwa LKPD berorientasi HOTS yang dikembangkan bersifat efektif, hal tersebut dapat dilihat dari jumlah peserta didik yang mencapai nilai KKM sebanyak 25 orang dengan persentase secara klasikal sebesar 83,33% sehingga dinyatakan efektif.
Kata kunci: efektif, LKPD, HOTS, Evolusi
Presepsi Siswa Kelas XII Terhadap Praktikum Bioteknologi Di Sekolah Menengah Atas ( SMA)
Authors: Basri Rafyka , Dongoran Pitri Hairani , Syafitri Dinda , Silaban Agista Putri Wahyudi , Hayati Zahrafal 
Published: May 2023

This research was conducted with the aim of knowing how the perception of class XII high school (SMA) students towards biotechnology practicum activities. This study uses a survey research method was conducted online with a google form. The research subject selection technique was using the purposive sampling technique, totaling 20 people from different schools. The results obtained are students' perceptions of preparation and practicum planning activities are considered very good, namely 88.75%. Students' perceptions of the implementation of biotechnology practicum activities are considered good with a total score of 79.54%. Students' perceptions of closing activities in biotechnology practicums were considered good with a total score of 82.61%. The shortcomings and obstacles found in biotechnology practicum activities based on the experience and perceptions of class XII high school students are that there are still practicum activities carried out in the classroom, the teacher does not inform the purpose of the practicum activities carried out, the practicum activities carried out are only limited to simple practicum activities in the form of conventional biotechnology. In making tapai and tempeh, the teacher still does not give a test at the beginning of the practicum activity and the limited time for practicum activities makes the implementation of practicum activities less than optimal.
Key words: Biotechnology, Practicum, High School Students, Student Perception

ABSTRAK
Penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimana persepsi siswa kelas XII Sekolah Menegah Atas (SMA) terhadap kegiatan praktikum bioteknologi. Penelitian ini menggunakan metode penelitian survei dengan sifat deskriptif secara online dengan google form. Teknik pemilihan subjek penelitian dengan menggunakan teknik Purposive Sampling yaitu dengan penentuan sampel dengan kriteria tertentu, yaitu 20 orang siswa dari sekolah yang berbeda-beda. Adapun hasil yang diperoleh adalah Persepsi siswa terhadap kegiatan persiapan dan perencanaan praktikum dinilai sangat baik yaitu 88,75%. Persepsi siswa terhadap kegiatan pelaksanaan praktikum bioteknologi dinilai baik dengan skor total 79,54%. Persepsi siswa terhadap kegiatan penutupan pada praktikum bioteknologi dinilai baik dengan skor total 82,61%. Adapun kekurangan dan kendala yang ditemukan dalam kegiatan praktikum bioteknologi berdasarkan pengalaman dan persepsi siswa SMA kelas XII adalah kegiatan praktikum masih ada yang dilakukan didalam kelas, guru tidak memberitahukan tujuan dari kegatan praktikum yang dilaksanakan, kegiatan praktikum yang dilaksanakan hanya sebatas kegiatan praktikum sederhana berupa bioteknologi konvesianal pembuatan tapai dan tempe, guru masih tidak memberikan tes diawal kegiatan praktikum dan terbatasnnya waktu kegiatan praktikum sehingga membuat pelaksanaan kegiatan praktikum kurang maksimal.
Kata kunci: Bioteknologi, Praktikum, Siswa SMA, Presepsi Siswa
Faculty and Resident Perspectives of the Complexity of Wellness Program Implementation: A Qualitative Exploration
Authors: Schneiderhan Jill , Bishop Thomas , Guetterman Timothy C. , Dobson Meg 
Published: May 2023

Introduction: Developing and implementing a wellness curriculum in a family medicine residency program is a complex process. We developed and implemented a new wellness curriculum in line with the national wellness conversation with a focus on the allocation of dedicated resources, the use of evidence-informed interventions, and the goal to be responsive to the feedback of both residents and residency leadership. Our research aim was to better understand the complexity of wellness curriculum implementation with a focus on identification of challenges to implementation.
Methods: We developed a wellness program with structured curricular elements initially focused on evidence-informed skill development that iterated after year 1 to include more process-oriented elements. For the years 2016-2019 we collected and analyzed qualitative, open-ended survey questions, anonymous resident curriculum feedback, and faculty observation forms to assess resident and faculty perspectives on the new curriculum.
Results: One hundred eighty-three survey invitations were sent with 122 total responses (66.7% response rate). Forty-eight of 56 residents responded to at least one survey. We analyzed responses along with the additional qualitative data that revealed several themes impacting the work of residency wellness curriculum implementation. These included how to manage curricular time, where the locus of control for the curricular content resides, and how residents and faculty differ in their definitions of wellness.
Conclusions: We believe programs will be well positioned if they further investigate the complex structures at play that influence residency wellness, including both systemic factors and individual and community level interventions, and design curriculum that is well-defined, includes essential elements, and is informed by resident participation.
Auditors’ Technological Proximity Knowledge
Authors: He Yue , Kim Jeong-Bon , Li Bing , Liu Zhenbin 
Published: May 2023

ABSTRACT
We exploit the technological closeness among clients of the same auditor to examine whether auditors accumulate knowledge from their clients’ technological proximity. We find that a client firm’s technological proximity to other clients of its audit office improves audit quality and results in an audit fee discount, even after controlling for the product similarity effect, auditors’ overall technological expertise, and industry specialization. Both an increase in audit quality and a decrease in audit fees occur if a client firm exhibits greater technological similarity to clients of other audit offices within the same audit firm. Our findings suggest that the auditors’ technological proximity knowledge enhances the effectiveness and efficiency of audit work at both the audit firm and audit office levels.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M41; M49; O30.
Kerukunan Umat Beragama Di Desa Candikuning, Tabanan, Bali, (Sejarah, Wujud, Nilai-Nilai) Dan Potensinya Sebagai Media Pendidikan Multikultur Di SMA
Authors: Merta Kusuma I Gede , Maryati Tuty , Arta Ketut Sedana 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui: (1) Sejarah Terbentuknya Desa Candikuning, (2) wujud kerukunan masyarakat di Candikuning dan (3) nilai-nilai dari masyarakat Desa Candikuning yang dapat digunakan sebagai sumber belajar pendidikan multikultur di SMA. Penelitian ini merupakan penelitian kualitatif. Metode yang digunakan adalah metode penelitian sejarah melalui beberapa langkah yakni : (1) heuristik ( teknik penentuan informan, observasi, studi dokumen, dan wawancara), (2) interpretasi dan (3) historiografi. Data yang terkumpul dianalisis secara kualitatif dengan model analisis Miles dan Huberman. Hasil penelitian menunjukan 1) Desa Candikuning sudah berdiri sebelum abad ke-14 yang dibuka oleh oleh Kaki Nengah bersama dua orang kawannya yaitu Pan Komang dan I Ketut Telaga, 2) wujud kerukunan masyarakat Candikuning dapat dilihat dari 4 aspek, yaitu : agama, sosial, politik dan ekonomi dan 3) nilai-nilai masyarakat Desa Candikuning sebagai media pendidikan multikultur di SMA adalah a) nilai religius, b) nilai toleransi, c) nilai kreatif, d) nilai inovatif, e) nilai kebangsaan, f) nilai bersahabat/berkomunikasi, g) nilai peduli lingkungan dan h) nilai peduli sosial.
Kata Kunci : kerukunan, multikultur, media pembelajaran
Pengembangan Aplikasi Articulate Storyline Berbasis Model Pembelajaran Discovery Learning Untuk Meningkatkan Hasil Belajar Sejarah Indonesia Di SMA Negeri 1 Tegaldlimo
Authors: Novita Sari Indah Ayu , Purnawati Desak Made Oka , Pardi I Wayan 
Published: May 2023

Latar belakang penelitian ini adalah minimnya Sumber belajar yang diberikan guru kepada siswa yang hanya bersifat tekstual saja, kurang adanya kreasi seperti gambar, audio, ataupun video yang bisa menjelaskan isi materi secara rinci dan menarik. Penelitian ini bertujuan untuk menghasilkan media pembelajaran interaktif berbasis Discovery Learning pada mata pelajaran Sejarah Indonesia di SMA Negeri 1 Tegaldlimo. Jenis penelitian yang digunakan adalah Research & Development (R&D), dengan model ADDIE (Analyze, Design, Development, Implementation and Evaluation). Subjek dari penelitian ini adalah pada siswa kelas X IPS 2 SMA Negeri 1 Tegaldlimo yang berjumlah 36 siswa. Dari penelitian ini, diperoleh sebuah produk media pembelajaran interaktif dengan menggunakan Articulate Storyline, hasil yang diperoleh dari validitas ahli isi dan ahli media mendapat rata-rata sebesar 1,00 “sangat tinggi”, dari uji coba perorangan, kelompok kecil dan kelompok besar masing-masing mendapat nilai rata-rata 83%, 85% dan 83% dengan kriteria “Baik”. Selain itu, hasil dari respon guru mendapatkan rata-rata sebesar 50 dengan kriteria “sangat praktis” dan peserta didik mendapatkan rata-rata sebesar 60,19 dengan kriteria “Sangat Praktis”. Sehingga, dapat disimpulkan bahwa media pembelajaran interaktif ini sudah layak untuk digunakan dalam proses pembelajaran.
Kata Kunci: Discovery learning, Pembelajaran Interaktif, ADDIE
The Effect of Hypericum perforatum Extract on Gastric Ulcer Development in Rat Models
Authors: Hussein Mohammed M. 
Published: May 2023

Gastric ulcer is a serious condition that results from the wearing/tearing of the stomach mucosa. A physiological equilibrium is maintained between mucosal defense and aggressive factors. In this study, the effectiveness of medicinal plants (Hypericum perforatum) in the management of gastric ulcer was compared to that of omeprazole, a well-known drug for gastric ulcer. This study involved numerous study groups of male rats comprising of the following: the first group (control group exposed to H. pylori and fed with normal animal feed), the second group (rats exposed to H. pylori and treated with two doses {of 250 mg/kg and 500 mg/kg} of aqueous H. perforatum), and the third group (rats exposed to H. pylori and treated with 20 mg/kg of omeprazole). The outcome of the study demonstrated that a high dose of H. perforatum prevents (50.65%) the development of stomach ulcers. The group treated with omeprazole revealed a formation of stomach ulcers (24.50%). A high dose of the aqueous plant extracts showed greater effectiveness in preventing gastric ulcer formation compared to the lower dosage.
Audiodescription d’un film d’animation: défis d’un projet pratique universitaire
Authors: Mihalache Iulia 
Published: May 2023

L’audiodescription (AD) est un service d’assistance artistique et médiatique en plein essor « qui rend les produits audiovisuels accessibles et agréables pour le public aveugle et les personnes malvoyantes en transférant des images et des sons flous dans une narration verbale qui interagit avec les dialogues et les sons du texte original avec lequel elle forme un tout cohérent » (Reviers et Vercauteren 2013 dans Vercauteren 2016 : 11). Comme objet d’étude et comme pratique intersémiotique, intersémiosphérique ou intermodale, l’audiodescription est devenue un domaine d’intérêt majeur non seulement en traduction audiovisuelle, mais aussi en traductologie (Taylor et Perego 2022). Cet intérêt va de pair avec les développements technologiques dans l’industrie de la traduction qui reflètent quelques tendances mondiales, parmi lesquelles l’augmentation du besoin de localisation (traduction) audiovisuelle (Bussey 2019 : en ligne).
Dans cet article, nous présentons et analysons notre propre performance, en tant qu’étudiante au Master Traduction Audiovisuelle : Localisation, Sous-titrage et Doublage (ISTRAD, Instituto Superior de Estudios Lingüísticos y Traducción, et Université de Cadix) (promotion 2020-2022), de l’audiodescription du film d’animation Pour la France, un film de fin d’études en animation 2D, à thématique historique, réalisé en 2019 par Vincent Chansard, dans le cadre de la formation « Concepteur et réalisateur de films d’animation » de Gobelins, école de l’image. Après avoir défini notre cadre théorique, nous exposons notre méthodologie basée sur les principales étapes de réalisation de ce mode de traduction qu’est l’audiodescription, en mettant en relief les différents défis que nous avons rencontrés et les solutions que nous avons apportées.
Use of Mentha spicata essential oil for prolonging postharvest life of fresh vegetables
Authors: Čmiková Natália , Galovičová Lucia , Schwarzová Marianna , Kačániová Miroslava 
Published: May 2023

Abstract

Mentha spicata L. (Lamiaceae), commonly called spearmint, is cultivated worldwide for its remarkable aroma and commercial value. Antimicrobial effectiveness of essential oils against many foodborne microorganisms when applied directly has been extensively demonstrated. The antimicrobial potential of Mentha spicata essential oil in the vapor phase against different microorganisms (Salmonella enterica subsp. enterica CCM 3807, Yersinia enterocolitica CCM 5671, Enterococcus faecalis CCM 4224, Staphylococcus aureus subsp. aureus CCM 2461, Candida albicans CCM 8186, C. glabrata CCM 8270, C. krusei CCM 8271, C. tropicalis CCM 8223) was determined by in situ method on vegetable model (carrot, radish, potatoes, and kohlrabi). The vapor phase was determined for seven days in Petri dishes with four concentrations (500, 250, 125, 62.5 μL.L−1) of M. spicata essential oil on the food models. M. spicata essential oil against Yersinia enterocolitica on carrot, potato, and kohlrabi model in concentration of 500 μL.L−1 was the most effective. M. spicata essential oil shows good potential as preservative and shelf-life prolongation of vegetables.