bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis
Authors: Skalinski Lacita Menezes , Santos Aline Elena Sacramento , Paixão Enny , Itaparica Martha , Barreto Florisneide , da Conceição Nascimento Costa Maria , Teixeira Maria Glória 
Published: May 2023

Abstract
Background
Seroprevalence studies about chikungunya infection are usually conducted after epidemics to estimate the magnitude of the attack. This study aimed to estimate the seroprevalence of CHIKV by WHO region, considering the periods of introduction of the virus in these regions and its potential to lead to epidemics.

Methods
We systematically reviewed Medline/Pubmed, Embase, Lilacs, Scopus and Web of Science for original articles published up to 2020. Cohort, case-control and cross-sectional studies were eligible for inclusion, based on the results of laboratory diagnosis of previous or previous and recent infection. Those conducted with symptomatic individuals were excluded.

Results
596 articles were identified, 197 full-text were reviewed and 64 were included, resulting in 71 seroprevalences. Most were cross-sectional studies (92%), between 2001 and 2020 (92%), with population of all ages (55%), conducted in Kenya (10.9%), Brazil (9.4%) and French Polynesia (7.8%). The pooled estimates were 24% (95%CI 19–29; I2 = 99.7%; p < 0.00), being 21% (95%CI 13–30; I2 = 99.5%; p < 0.00) for adults, 7% (95%CI 0–23; I2 = 99.7%; p < 0.00) for children and 30% (95%CI 23–38; I2 = 99.7%; p < 0.00) for all ages. The higher seroprevalences were found in African, the Americas and South-East Asian Regions.

Conclusions
The great heterogeneity of seroprevalences points to the persistence of viral circulation. Even where the seroprevalence is high, the population replacement and the absence of vaccines mean that the risk of virus spread and epidemics remains.

Registration
PROSPERO CRD42020166227.
Resource-dependent biodiversity and potential multi-trophic interactions determine belowground functional trait stability
Authors: Zhu Lingyue , Chen Yan , Sun Ruibo , Zhang Jiabao , Hale Lauren , Dumack Kenneth , Geisen Stefan , Deng Ye , Duan Yinghua , Zhu Bo , Li Yan , Liu Wenzhao , Wang Xiaoyue , Griffiths Bryan S. , Bonkowski Michael , Zhou Jizhong , Sun Bo 
Published: May 2023

AbstractBackgroundFor achieving long-term sustainability of intensive agricultural practices, it is pivotal to understand belowground functional stability as belowground organisms play essential roles in soil biogeochemical cycling. It is commonly believed that resource availability is critical for controlling the soil biodiversity and belowground organism interactions that ultimately lead to the stabilization or collapse of terrestrial ecosystem functions, but evidence to support this belief is still limited. Here, we leveraged field experiments from the Chinese National Ecosystem Research Network (CERN) and two microcosm experiments mimicking high and low resource conditions to explore how resource availability mediates soil biodiversity and potential multi-trophic interactions to control functional trait stability.ResultsWe found that agricultural practice-induced higher resource availability increased potential cross-trophic interactions over 316% in fields, which in turn had a greater effect on functional trait stability, while low resource availability made the stability more dependent on the potential within trophic interactions and soil biodiversity. This large-scale pattern was confirmed by fine-scale microcosm systems, showing that microcosms with sufficient nutrient supply increase the proportion of potential cross-trophic interactions, which were positively associated with functional stability. Resource-driven belowground biodiversity and multi-trophic interactions ultimately feedback to the stability of plant biomass.ConclusionsOur results indicated the importance of potential multi-trophic interactions in supporting belowground functional trait stability, especially when nutrients are sufficient, and also suggested the ecological benefits of fertilization programs in modern agricultural intensification.
Efficient production of salvianic acid A from l-dihydroxyphenylalanine through a tri-enzyme cascade
Authors: Yang Jiahui , Wei Wanqing , Gao Changzheng , Song Wei , Gao Cong , Chen Xiulai , Liu Jia , Guo Liang , Liu Liming , Wu Jing 
Published: May 2023

AbstractSalvianic acid A (SAA), used for treating cardiovascular and cerebrovascular diseases, possesses several pharmacological properties. However, the current methods for the enzymatic synthesis of SAA show low efficiency. Here, we constructed a three-enzyme cascade pathway in Escherichia coli BL21 (DE3) to produce SAA from l-dihydroxyphenylalanine (L-DOPA). The phenylpyruvate reductase (LaPPR) from Lactobacillus sp. CGMCC 9967 is a rate-limiting enzyme in this process. Therefore, we employed a mechanism-guided protein engineering strategy to shorten the transfer distances of protons and hydrides, generating an optimal LaPPR mutant, LaPPRMu2 (H89M/H143D/P256C), with a 2.8-fold increase in specific activity and 9.3-time increase in kcat/Km value compared to that of the wild type. Introduction of the mutant LaPPRMu2 into the cascade pathway and the optimization of enzyme levels and transformation conditions allowed the obtainment of the highest SAA titer (82.6 g L−1) ever reported in vivo, good conversion rate (91.3%), excellent ee value (99%) and the highest productivity (6.9 g L−1 h−1) from 90 g L−1 L-DOPA in 12 h. This successful strategy provides a potential new method for the industrial production of SAA.
Graphical Abstract
Artificial intelligence-based refractive error prediction and EVO-implantable collamer lens power calculation for myopia correction
Authors: Jiang Yinjie , Shen Yang , Chen Xun , Niu Lingling , Li Boliang , Cheng Mingrui , Lei Yadi , Xu Yilin , Wang Chongyang , Zhou Xingtao , Wang Xiaoying 
Published: May 2023

Abstract
Background
Implantable collamer lens (ICL) has been widely accepted for its excellent visual outcomes for myopia correction. It is a new challenge in phakic IOL power calculation, especially for those with low and moderate myopia. This study aimed to establish a novel stacking machine learning (ML) model for predicting postoperative refraction errors and calculating EVO-ICL lens power.

Methods
We enrolled 2767 eyes of 1678 patients (age: 27.5 ± 6.33 years, 18–54 years) who underwent non-toric (NT)-ICL or toric-ICL (TICL) implantation during 2014 to 2021. The postoperative spherical equivalent (SE) and sphere were predicted using stacking ML models [support vector regression (SVR), LASSO, random forest, and XGBoost] and training based on ocular dimensional parameters from NT-ICL and TICL cases, respectively. The accuracy of the stacking ML models was compared with that of the modified vergence formula (MVF) based on the mean absolute error (MAE), median absolute error (MedAE), and percentages of eyes within ± 0.25, ± 0.50, and ± 0.75 diopters (D) and Bland-Altman analyses. In addition, the recommended spheric lens power was calculated with 0.25 D intervals and targeting emmetropia.

Results
After NT-ICL implantation, the random forest model demonstrated the lowest MAE (0.339 D) for predicting SE. Contrarily, the SVR model showed the lowest MAE (0.386 D) for predicting the sphere. After TICL implantation, the XGBoost model showed the lowest MAE for predicting both SE (0.325 D) and sphere (0.308 D). Compared with MVF, ML models had numerically lower values of standard deviation, MAE, and MedAE and comparable percentages of eyes within ± 0.25 D, ± 0.50 D, and ± 0.75 D prediction errors. The difference between MVF and ML models was larger in eyes with low-to-moderate myopia (preoperative SE >  − 6.00 D). Our final optimal stacking ML models showed strong agreement between the predictive values of MVF by Bland-Altman plots.

Conclusion
With various ocular dimensional parameters, ML models demonstrate comparable accuracy than existing MVF models and potential advantages in low-to-moderate myopia, and thus provide a novel nomogram for postoperative refractive error prediction and lens power calculation.
Masticatory muscle tendon-aponeurosis hyperplasia that was initially misdiagnosed for polymyositis: a case report and review of the literature
Authors: Katagiri Wataru , Saito Daisuke , Maruyama Satoshi , Ike Makiko , Nisiyama Hideyoshi , Hayashi Takafumi , Tanuma Jun-ichi , Kobayashi Tadaharu 
Published: May 2023

Abstract
Background
Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is a relatively newly identified clinical condition that manifests as trismus with a square-shaped mandible. Herein, we report a case of MMATH that was initially misdiagnosed for polymyositis due to trismus and simultaneous lower limb pain, with literature review.

Case presentation
A 30-year-old woman had a history of lower limb pain after exertion for 2 years. Initial physical examination had been performed at the Department of General Medicine in our hospital. There was also redness in the hands and fingers. Although polymyositis was suspected, it was denied. The patient visited our department for right maxillary wisdom tooth extraction.
Clinical examination revealed that the patient had a square-shaped mandible. The maximal mouth opening was 22 mm. There was no temporomandibular joint pain at the time of opening. Furthermore, there was awareness of clenching while working. Panoramic radiography revealed developed square mandibular angles with flattened condyles. Computed tomography showed enlarged masseter muscles with high-density areas around the anterior and lateral fascia. Magnetic resonance imaging also showed thickened tendons and aponeuroses on the anterior surface and inside bilateral masseter muscles. Finally, the patient was diagnosed with MMTAH. Bilateral aponeurectomy of the masseter muscles with coronoidectomy and masseter muscle myotomy was performed under general anesthesia. The maximum opening during surgery was 48 mm. Mouth opening training was started on day 3 after surgery. Histopathological examination of the surgical specimen showed that the muscle fibers were enlarged to 60 μm. Immunohistochemistry testing for calcineurin, which was associated with muscle hypertrophy due to overload in some case reports, showed positive results. Twelve months after surgery, the mouth self-opening and forced opening were over 35 mm and 44 mm, respectively.

Conclusions
Herein, we report a case of MMATH. Lower limb pain due to prolonged standing at work and overload due to clenching were considered risk factors for symptoms onset of MMATH.
Specifically designed 10-Fe1Mn1-USY hydrophobicity material for acetone adsorption under high humidity condition
Authors: Nguyen Nhat-Thien , Nguyen Thi-Minh-Phuong , Caparanga Alvin-R , Chiu Yi-Ren , Duong Cong-Chinh , Duong Thi-Thanh , Guan Chung-Yu , Hong Gui-Bing , Chang Chang-Tang 
Published: May 2023

AbstractAcetone is a solvent used in many laboratories and factories. Serious problems will occur when it is exposed to the environment. Therefore, a new design hydrophobicity bimetallic metal material (10-Fe1Mn1-USY) was prepared for acetone adsorption under conditions of high humidity. Hydrophobic Y type zeolite was used to prepare bimetallic metal materials and the effect of different operating parameters (including different material, humidity, temperature, pollutant concentration, residence time, and regeneration) on the efficiency of acetone treatment was examined. Isothermal adsorption model, kinetics and thermodynamic model analysis were also used to establish the reaction mechanism. The 10-Fe1Mn1-USY material has good adsorption capacity (133 mg g−1) for acetone under a relative humidity of 50%. The main factors affecting the adsorption capacity are the contact angle, hydrophobicity, specific surface area, and Si/Al of the material. The isothermal adsorption and the kinetic adsorption behavior of 10-Fe1Mn1-USY material for acetone are more suitable for the Temkin isotherm adsorption model and the pseudo-first-order kinetic model. The adsorption of acetone by 10-Fe1Mn1-USY material is dominated by intra-particle diffusion. According to the thermodynamic analysis results, the adsorption behavior of 10-Fe1Mn1-USY material for acetone is a type of physical adsorption, and a spontaneous and non-sequential reaction.
Effects of High-Intensity Interval Training and Combined High-Intensity Interval Training Programs on Cancer-Related Fatigue and Cancer Pain: A Systematic Review and Meta-analysis
Authors: WANG LEZHENG , QUAN MINGHUI , NIEMAN DAVID C. , LI FEI , SHI HUI , BAI XINYUE , XIONG TING , WEI XINGYI , CHEN PEIJIE , SHI YUE 
Published: May 2023

ABSTRACT

Purpose
This systematic review and meta-analysis assessed the effectiveness of high-intensity interval training (HIIT) alone and combined HIIT programs compared with usual care on cancer-related fatigue (CRF) and pain related to cancer or cancer-related treatments.

Methods
Articles published prior to January 2023 were searched in the following digital databases: PubMed, Cochrane Database of Systematic Reviews and Cochrane Controlled Clinical Trials (CENTRAL), Web of Science, Scopus and ScienceDirect. Randomized controlled trials were included that met the following criteria: (i) adult cancer patients and survivors (>18 yr old); (ii) HIIT or combined HIIT programs versus usual care; (iii) assessment of fatigue and pain. Cochrane tool was used for assessing Risk of Bias (RoB) and Review Manager (RevMan 5.2) was used for data analysis.

Results
Based on limited number (12) of studies included, we found HIIT and combined HIIT interventions have significant effect sizes on reducing both CRF (standardized mean difference, 0.63; 95% confidence interval, 0.42–0.84; P < 0.001) and cancer-associated pain (standardized mean difference, 0.44; 95% confidence interval, 0.25–0.63; P < 0.001).

Conclusions
This systematic review and meta-analysis indicate that HIIT and combined HIIT programs can reduce CRF and pain.
Joint and Limb Loading during Gait in Adults with ACL Reconstruction: Comparison between Single-Step and Cumulative Load Metrics
Authors: GARCIA STEVEN A. , PAMUKOFF DEREK N. , JOHNSON ALEXA K. , PALMIERI-SMITH RIANN M. 
Published: May 2023

ABSTRACT

Purpose
Individuals with anterior cruciate ligament reconstruction (ACLR) generally exhibit limb underloading behaviors during walking, but most research focuses on per-step comparisons. Cumulative loading metrics offer unique insight into joint loading as magnitude, duration, and total steps are considered, but few studies have evaluated if cumulative loads are altered post-ACLR. Here, we evaluated if underloading behaviors are apparent in ACLR limbs when using cumulative load metrics and how load metrics change in response to walking speed modifications.

Methods
Treadmill walking biomechanics were evaluated in 21 participants with ACLR at three speeds (self-selected (SS); 120% SS and 80% SS). Cumulative loads per step and per kilometer were calculated using knee flexion and adduction moment (KFM and KAM) and vertical ground reaction force (GRF) impulses. Traditional magnitude metrics for KFM, KAM, and GRF were also calculated.

Results
The ACLR limb displayed smaller KFM and GRF in early and late stances, but larger KFM and GRF during midstance compared with the contralateral limb (P < 0.01). Only GRF cumulative loads (per step and per kilometer) were reduced in the ACLR limb (P < 0.01). In response to speed modifications, load magnitudes generally increased with speed. Conversely, cumulative load metrics (per step and per kilometer) decreased at faster speeds and increased at slow speeds (P < 0.01).

Conclusions
Patients with ACLR underload their knee in the sagittal plane per step, but cumulatively over the course of many steps/distance, this underloading phenomenon was not apparent. Furthermore, cumulative load increased at slower speeds, opposite to what is identified with traditional single-step metrics. Assessing cumulative load metrics may offer additional insight into how load outcomes may be impacted in injured populations or in response to gait modifications.
Resisting Their Programming
Authors: Kee Chera 
Published: May 2023

Interrogating the biopolitical logics governing life in the Star Wars universe, I use The Clone Wars (2008-2014; 2020) to consider how the franchise challenges the devaluation of some lives while simultaneously marking others as disposable.
The most explicit way The Clone Wars deals with questions of expendability is through the clones. Many clone-centric stories center on clones questioning their status as cannon fodder. Using the clones Cut Lawquane, 99, Gregor, and Fives, I argue that the show promotes the idea of resisting one’s biopolitical fate—but only within limited parameters. Some clones can rise above their status as replaceable bodies; others can’t. As only some clones are able to claim full rights to life, the show’s exploration of the ethical dilemmas of war becomes diluted by a continual devaluing of those lives that are hidden behind masks and designations rather than faces and names.
To that end, I also examine how droids serve as counterparts to the clones: in a narrative universe where droids are often given personalities, some droids are valued as “living” beings while others can be killed without remorse. Yet, it isn’t a droid’s proximity to a human appearance that determines their status; rather, like the clones, it is the degree to which they have clearly distinguishable “human” identities. Thus, not only do both clones and droids serve as expendable weapons, but they also end up in the same unending state of exception that only a select few can ever escape.
Functional outcome after nonoperative management of minimally displaced greater tuberosity fractures and predictors of poorer patient experience
Authors: Makaram Navnit S. , Khan L. A. K. , Jenkins Paul J. , Robinson C. M. 
Published: May 2023

AimsThe outcomes following nonoperative management of minimally displaced greater tuberosity (GT) fractures, and the factors which influence patient experience, remain poorly defined. We assessed the early patient-derived outcomes following these injuries and examined the effect of a range of demographic- and injury-related variables on these outcomes.MethodsIn total, 101 patients (53 female, 48 male) with a mean age of 50.9 years (19 to 76) with minimally displaced GT fractures were recruited to a prospective observational cohort study. During the first year after injury, patients underwent experiential assessment using the Disabilities of the Arm, Shoulder and Hand (DASH) score and assessment of associated injuries using MRI performed within two weeks of injury. The primary outcome was the one-year DASH score. Multivariate analysis was used to assess the effect of patient demographic factors, complications, and associated injuries, on outcome.ResultsThe mean DASH score improved from 42.3 (SD 9.6) at six weeks post-injury, to 19.5 (SD 14.3) at one-year follow-up (p < 0.001), but outcomes were mixed, with 30 patients having a DASH score > 30 at one year. MRI revealed a range of associated injuries, with a full-thickness rotator cuff tear present in 19 patients (19%). Overall, 11 patients (11%) developed complications requiring further operative intervention; 20 patients (21%) developed post-traumatic secondary shoulder stiffness. Multivariate analysis revealed a high-energy mechanism (p = 0.009), tobacco consumption (p = 0.033), use of mobility aids (p = 0.047), a full-thickness rotator cuff tear (p = 0.002), and the development of post-traumatic secondary shoulder stiffness (p = 0.035) were independent predictors of poorer outcome.ConclusionThe results of nonoperative management of minimally displaced GT fractures are heterogeneous. While many patients have satisfactory early outcomes, a substantial subgroup fare much worse. There is a high prevalence of rotator cuff injuries and post-traumatic shoulder stiffness, and their presence is associated with poorer patient experience. Furthermore, patients who have a high-energy injury, smoke, or use walking aids, have worse outcomes.Cite this article: Bone Joint J 2023;105-B(5):534–542.
The efficacy of split tibial tendon transfers on functional gait outcomes for children and youth with cerebral palsy and spastic equinovarus foot deformities
Authors: Hochstetter-Owen Jennifer , Stott Susan , Williams Sîan A. 
Published: May 2023

AimsTo systematically review the efficacy of split tendon transfer surgery on gait-related outcomes for children and adolescents with cerebral palsy (CP) and spastic equinovarus foot deformity.MethodsFive databases (CENTRAL, CINAHL, PubMed, Embase, Web of Science) were systematically screened for studies investigating split tibialis anterior or split tibialis posterior tendon transfer for spastic equinovarus foot deformity, with gait-related outcomes (published pre-September 2022). Study quality and evidence were assessed using the Methodological Index for Non-Randomized Studies, the Risk of Bias In Non-Randomized Studies of Interventions, and the Grading of Recommendations Assessment, Development and Evaluation.ResultsOverall, 17 studies (566 feet) were included: 13 studies used clinical grading criteria to report a postoperative ‘success’ of 87% (75% to 100%), 14 reported on orthotic use with 88% reduced postoperative use, and one study reported on ankle kinematics improvements. Ten studies reported post-surgical complications at a rate of 11/390 feet (2.8%), but 84 feet (14.8%) had recurrent varus (68 feet, 12%) or occurrence of valgus (16 feet, 2.8%). Only one study included a patient-reported outcome measure (pain).ConclusionSplit tendon transfers are an effective treatment for children and youth with CP and spastic equinovarus foot deformities. Clinical data presented can be used for future study designs; a more standardized functional and patient-focused approach to evaluating outcomes of surgical intervention of gait may be warranted.Cite this article: Bone Jt Open 2023;4(5):283–298.
High-throughput multimodal wide-field Fourier-transform Raman microscope
Authors: Ardini B. , Bassi A. , Candeo A. , Genco A. , Trovatello C. , Liu F. , Zhu X. , Valentini G. , Cerullo G. , Vanna R. , Manzoni C. 
Published: May 2023

Raman microscopy is a powerful analytical technique for materials and
life sciences that enables mapping the spatial distribution of the
chemical composition of a sample. State-of-the-art Raman microscopes,
based on point-scanning frequency-domain detection, have long (∼1s) pixel dwell times, making it
challenging to acquire images of a significant area (e.g., 100×100µm). Here we present a compact
wide-field Raman microscope based on a time-domain Fourier-transform
approach, which enables parallel acquisition of the Raman spectra on
all pixels of a 2D detector. A common-path birefringent interferometer
with exceptional delay stability and reproducibility can rapidly
acquire Raman maps (∼30min for a 250000pixel image) with high spatial (<1µm) and spectral (∼23cm−1) resolutions. Time-domain detection
allows us to disentangle fluorescence and Raman signals, which can
both be measured separately. We validate the system by Raman imaging
plastic microbeads and demonstrate its multimodal operation by
capturing fluorescence and Raman maps of a multilayer-WSe2 sample, providing complementary
information on the strain and number of layers of the material.