bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplemental Material: U-Pb and Re-Os geochronology and geochemistry of the Ulgen hidden porphyry Mo deposit in the Derbugan metallogenic belt (NE China): Insights into petrogenesis and tectonic setting
Authors: Xia Tianjiao , Liang Xinquan , et al.  
Published: May 2023

<p>Table S1: Lithology, occurrences, and locations of samples selected for zircon U-Pb, molybdenite Re-Os, whole-rock major- and trace-element analysis, zircon Hf, and Sr-Nd-Pb isotope analysis. Table S2: Zircon LA-ICP-MS U-Pb data of the granitoids. Table S3: Re-Os data of molybdenite from the Ulgen porphyry Mo deposit. Table S4: Whole-rock major- and trace-element compositions of the monzogranitic porphyry, muscovite monzonitic granite, and biotite granitic porphyry. Table S5: Sr-Nd-Pb isotopic compositions of the granitoids in the Ulgen deposit. Table S6: Zircon Lu-Hf isotopic composition of the granitoids. Table S7: Trace-element (ppm) data of zircon grains from the granitoids. </p>
Combined hormonal contraceptive use is not protective against musculoskeletal conditions or injuries: a systematic review with data from 5 million females
Authors: White Lynita , Losciale Justin M , Squier Kipling , Guy Sarah , Scott Alex , Prior Jerilynn C , Whittaker Jackie L 
Published: May 2023

ObjectiveAssess the association between combined hormonal contraceptives (CHC) use and musculoskeletal tissue pathophysiology, injuries or conditions.DesignSystematic review with semiquantitative analyses and certainty of evidence assessment, guided by the Grading of Recommendations Assessment, Development and Evaluation approach.Data SourcesMEDLINE, EMBASE, CENTRAL, SPORTDiscus, CINAHL searched from inception to April 2022.EligibilityIntervention and cohort studies that assessed the association between new or ongoing use of CHC and an outcome of musculoskeletal tissue pathophysiology, injury or condition in postpubertal premenopausal females.ResultsAcross 50 included studies, we assessed the effect of CHC use on 30 unique musculoskeletal outcomes (75% bone related). Serious risk of bias was judged present in 82% of studies, with 52% adequately adjusting for confounding. Meta-analyses were not possible due to poor outcome reporting, and heterogeneity in estimate statistics and comparison conditions. Based on semiquantitative synthesis, there is low certainty evidence that CHC use was associated with elevated future fracture risk (risk ratio 1.02–1.20) and total knee arthroplasty (risk ratio 1.00–1.36). There is very low certainty evidence of unclear relationships between CHC use and a wide range of bone turnover and bone health outcomes. Evidence about the effect of CHC use on musculoskeletal tissues beyond bone, and the influence of CHC use in adolescence versus adulthood, is limited.ConclusionGiven a paucity of high certainty evidence that CHC use is protective against musculoskeletal pathophysiology, injury or conditions, it is premature and inappropriate to advocate, or prescribe CHC for these purposes.PROSPERO registration numberThis review was registered on PROSPERO CRD42021224582 on 8 January 2021.
Optimising prescribing in older adults with multimorbidity and polypharmacy in primary care (OPTICA): cluster randomised clinical trial
Authors: Jungo Katharina Tabea , Ansorg Anna-Katharina , Floriani Carmen , Rozsnyai Zsofia , Schwab Nathalie , Meier Rahel , Valeri Fabio , Stalder Odile , Limacher Andreas , Schneider Claudio , Bagattini Michael , Trelle Sven , Spruit Marco , Schwenkglenks Matthias , Rodondi Nicolas , Streit Sven 
Published: May 2023

Abstract

Objective
To study the effects of a primary care medication review intervention centred around an electronic clinical decision support system (eCDSS) on appropriateness of medication and the number of prescribing omissions in older adults with multimorbidity and polypharmacy compared with a discussion about medication in line with usual care.

Design
Cluster randomised clinical trial.

Setting
Swiss primary care, between December 2018 and February 2021.

Participants
Eligible patients were ≥65 years of age with three or more chronic conditions and five or more long term medications.

Intervention
The intervention to optimise pharmacotherapy centred around an eCDSS was conducted by general practitioners, followed by shared decision making between general practitioners and patients, and was compared with a discussion about medication in line with usual care between patients and general practitioners.

Main outcome measures
Primary outcomes were improvement in the Medication Appropriateness Index (MAI) and the Assessment of Underutilisation (AOU) at 12 months. Secondary outcomes included number of medications, falls, fractures, and quality of life.

Results
In 43 general practitioner clusters, 323 patients were recruited (median age 77 (interquartile range 73-83) years; 45% (n=146) women). Twenty one general practitioners with 160 patients were assigned to the intervention group and 22 general practitioners with 163 patients to the control group. On average, one recommendation to stop or start a medication was reported to be implemented per patient. At 12 months, the results of the intention-to-treat analysis of the improvement in appropriateness of medication (odds ratio 1.05, 95% confidence interval 0.59 to 1.87) and the number of prescribing omissions (0.90, 0.41 to 1.96) were inconclusive. The same was the case for the per protocol analysis. No clear evidence was found for a difference in safety outcomes at the 12 month follow-up, but fewer safety events were reported in the intervention group than in the control group at six and 12 months.

Conclusions
In this randomised trial of general practitioners and older adults, the results were inconclusive as to whether the medication review intervention centred around the use of an eCDSS led to an improvement in appropriateness of medication or a reduction in prescribing omissions at 12 months compared with a discussion about medication in line with usual care. Nevertheless, the intervention could be safely delivered without causing any harm to patients.

Trial registration

NCT03724539Clinicaltrials.gov
NCT03724539
Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them
Authors: Kyriacou Maro , Radford Shellie , Moran Gordon W 
Published: May 2023

BackgroundRefractory ulcerative proctitis presents a huge clinical challenge not only for the patients living with this chronic, progressive condition but also for the professionals who care for them. Currently, there is limited research and evidence-based guidance, resulting in many patients living with the symptomatic burden of disease and reduced quality of life. The aim of this study was to establish a consensus on the thoughts and opinions related to refractory proctitis disease burden and best practice for management.MethodsA three-round Delphi consensus survey was conducted among patients living with refractory proctitis and the healthcare experts with knowledge on this disease from the UK. A brainstorming stage involving a focus group where the participants came up with an initial list of statements was completed. Following this, there were three rounds of Delphi surveys in which the participants were asked to rank the importance of the statements and provide any additional comments or clarifications. Calculation of mean scores, analysis of comments and revisions were performed to produce a final list of statements.ResultsIn total, 14 statements were suggested by the focus group at the initial brainstorming stage. Following completion of three Delphi survey rounds, all 14 statements reached consensus following appropriate revision.ConclusionsWe established consensus on the thoughts and opinions related to refractory proctitis from both the experts who manage this disease and the patients living with it. This represents the first step towards developing clinical research data and ultimately the evidence needed for best practice management guidance of this condition.
Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
Authors: Broatch James R , Zarekookandeh Navabeh , Glarin Rebecca , Strik Myrte , Johnston Leigh A , Moffat Bradford A , Bird Laura J , Gunningham Kate , Churilov Leonid , Johns Hannah T , Askew Christopher D , Levinger Itamar , O’Riordan Shane F , Bishop David J , Brodtmann Amy 
Published: May 2023

IntroductionRegular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the association between greater cardiorespiratory fitness and larger brain volume, superior cognitive performance and lower dementia risk. However, the optimal aerobic exercise dose, namely the intensity and mode of delivery, to improve brain health and lower dementia risk has received less attention. We aim to determine the effect of different doses of aerobic exercise training on markers of brain health in sedentary middle-aged adults, hypothesising that high-intensity interval training (HIIT) will be more beneficial than moderate-intensity continuous training (MICT).Methods and analysisIn this two-group parallel, open-label blinded endpoint randomised trial, 70 sedentary middle-aged (45–65 years) adults will be randomly allocated to one of two 12-week aerobic exercise training interventions matched for total exercise training volume: (1) MICT (n=35) or HIIT (n=35). Participants will perform ~50 min exercise training sessions, 3 days per week, for 12 weeks. The primary outcome will be measured as between-group difference in cardiorespiratory fitness (peak oxygen uptake) change from baseline to the end of training. Secondary outcomes include between-group differences in cognitive function and ultra-high field MRI (7T) measured markers of brain health (brain blood flow, cerebrovascular function, brain volume, white matter microstructural integrity and resting state functional brain activity) changes from baseline to the end of training.Ethics and disseminationThe Victoria University Human Research Ethics Committee (VUHREC) has approved this study (HRE20178), and all protocol modifications will be communicated to the relevant parties (eg, VUHREC, trial registry). Findings from this study will be disseminated via peer-review publications, conference presentations, clinical communications and both mainstream and social media.Trial registration numberANZCTR12621000144819.
Ultrasound-guided pulsed radiofrequency versus dry needling for pain management in chronic neck and shoulder myofascial pain syndrome patients at a tertiary hospital in China: a randomised controlled trial protocol
Authors: Wang Jin , Zhang Yuelun , Cui Xulei , Shen Le 
Published: May 2023

IntroductionMyofascial pain syndrome (MPS), especially in the neck and shoulder region, is one of the most common chronic pain disorders worldwide. Dry needling (DN) and pulsed radiofrequency (PRF) are the two effective methods for treating MPS. We aimed to compare the effects of DN and PRF in chronic neck and shoulder MPS patients.Methods and analysisThis is a prospective, single-centre, randomised, controlled trial in a tertiary hospital. We plan to recruit 108 patients aged 18–70 years who are diagnosed with chronic MPS in the neck, shoulder and upper back regions and randomly allocate them to either the DN or PRF group at a 1:1 ratio. The DN group will receive ultrasound-guided intramuscular and interfascial DN 8–10 times per pain point or until local twitch responses are no longer elicited and 30 min of indwelling. The PRF group will receive ultrasound-guided intramuscular (0.9% saline 2 mL, 42℃, 2 Hz, 2 min) and interfascial (0.9% saline 5 mL, 42℃, 2 Hz, 2 min) PRF. Follow-up will be performed by the research assistant at 0, 1, 3 and 6 months postoperatively. The primary outcome is the postoperative 6-month pain visual analogue score (0–100 mm). Secondary outcomes include pressure pain threshold measured by an algometer, Neck Disability Index, depression (Patient Health Questionnaire-9), anxiety (Generalised Anxiety Disorder-7), sleep status (Likert scale) and overall quality of life (36-Item Short Form Survey). Between-group comparisons will be analysed using either a non-parametric test or a mixed effects linear model.Ethics and disseminationThis study was approved by the medical ethics committee of Peking Union Medical College Hospital (JS-3399). All participants will give written informed consent before participation. The results from this study will be shared at conferences and disseminated in international journals.Trial registration numberNCT 05637047, Pre-results.
Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study
Authors: Li Shuying , Feng Li , Sun Xiaoxiao , Ding Jie , Zhou Weihong 
Published: May 2023

ObjectiveThe purposes of the study were to investigate the detailed association of serum uric acid (SUA) with visceral fat area (VFA) and body fat percentage (BFP) as calculated by bioelectrical impedance analysis (BIA) and build non-invasive diagnosis models of hyperuricaemia by combining obesity-related indicators, age and sex.MethodA total of 19 343 adults were included. Multivariable regression analysis models were employed to analyse the association of SUA with VFA and BFP. Receiver operating characteristic curves were generated to diagnose hyperuricaemia in adults.ResultsAfter fully adjusting for covariates, SUA was positively associated with VFA, BFP and body mass index (BMI) with βs of 0.447, 2.522 and 4.630 (95% CI= (0.412 to 0.482), (2.321 to 2.723) and (4.266 to 4.994)). After stratification by gender, this association persists (p<0.001). Fitted smoothing curves identified non-linear relationships between SUA and both VFA and BMI after full adjustment in males (inflection points: 93.9 cm2and 30.9 kg/m2). A non-linear relationship also exists between SUA and BFP in females (inflection point: 34.5%). A combined model incorporating BFP, BMI, age and sex exhibited the best ability to diagnose hyperuricaemia (AUC (area under the curve) =0.805, specificity=0.602, sensitivity=0.878). For normal-weight and lean populations, individuals with hyperuricaemia tended to have higher levels of VFA and BFP in females and males, respectively (p<0.001). The combination of VFA, BFP, BMI, age and sex exhibited the best ability to diagnose hyperuricaemia in normal-weight and lean populations (AUC=0.803, specificity=0.671, sensitivity=0.836).ConclusionVFA and BFP are independent factors associated with SUA. In males, SUA shows a non-linear relationship with VFA and BMI. In females, SUA and BFP exhibit a non-linear relationship. In normal-weight and lean individuals, the accumulation of VFA and BFP may be involved in hyperuricaemia. VFA and BFP were helpful in diagnosing hyperuricaemia in adults, especially for normal-weight and lean populations.
Prevalence of angina pectoris and association with coronary atherosclerosis in a general population
Authors: Welén Schef Kerstin , Tornvall Per , Alfredsson Joakim , Hagström Emil , Ravn-Fischer Annica , Soderberg Stefan , Yndigegn Troels , Jernberg Tomas 
Published: May 2023

ObjectiveTo assess the contemporary prevalence of, and factors associated with angina pectoris symptoms, and to examine the relationship to coronary atherosclerosis in a middle-aged, general population.MethodsData were based on the Swedish CArdioPulmonary bioImage Study (SCAPIS), in which 30 154 individuals were randomly recruited from the general population between 2013 and 2018. Participants that completed the Rose Angina Questionnaire were included and categorised as angina or no angina. Subjects with a valid coronary CT angiography (CCTA) were categorised by degree of coronary atherosclerosis; ≥50% obstruction (obstructive coronary atherosclerosis), <50% obstruction or any atheromatosis (non-obstructive coronary atherosclerosis) or none (no coronary atherosclerosis).ResultsThe study population consisted of 28 974 questionnaire responders (median age 57.4 years, female 51.6%, hypertension 19.9%, hyperlipidaemia 7.9%, diabetes mellitus 3.7%), of which 1025 (3.5%) fulfilled the criteria of angina. Coronary atherosclerosis was more common in individuals having angina compared with those with no angina (n=24 602, obstructive coronary atherosclerosis 11.8% vs 5.4%, non-obstructive coronary atherosclerosis 38.9% vs 37.0%, no coronary atherosclerosis 49.4% vs 57.7%, all p<0.001). Factors independently associated with angina were birthplace outside of Sweden (OR 2.58 (95% CI 2.10 to 2.92)), low educational level (OR 1.41 (1.10 to 1.79)), unemployment (OR 1.51 (1.27 to 1.81)), poor economic status (OR 1.85 (1.38 to 2.47)), symptoms of depression (OR 1.63 (1.38 to 1.92)) and high degree of stress (OR 2.92 (1.80 to 4.73)).ConclusionAngina pectoris symptoms are common (3.5%) among middle-aged individuals of the general population of Sweden, though with low association to obstructive coronary atherosclerosis. Sociodemographic and psychological factors are highly associated with angina symptoms, irrespective of degree of coronary atherosclerosis.
Non-COVID-19 intensive care admissions during the pandemic: a multinational registry-based study
Authors: McLarty Joshua , Litton Edward , Beane Abigail , Aryal Diptesh , Bailey Michael , Bendel Stepani , Burghi Gaston , Christensen Steffen , Christiansen Christian Fynbo , Dongelmans Dave A , Fernandez Ariel L , Ghose Aniruddha , Hall Ros , Haniffa Rashan , Hashmi Madiha , Hashimoto Satoru , Ichihara Nao , Kumar Tirupakuzhi Vijayaraghavan Bharath , Lone Nazir I , Arias López Maria del Pilar , Mat Nor Mohamed Basri , Okamoto Hiroshi , Priyadarshani Dilanthi , Reinikainen Matti , Soares Marcio , Pilcher David , Salluh Jorge 
Published: May 2023

BackgroundThe COVID-19 pandemic resulted in a large number of critical care admissions. While national reports have described the outcomes of patients with COVID-19, there is limited international data of the pandemic impact on non-COVID-19 patients requiring intensive care treatment.MethodsWe conducted an international, retrospective cohort study using 2019 and 2020 data from 11 national clinical quality registries covering 15 countries. Non-COVID-19 admissions in 2020 were compared with all admissions in 2019, prepandemic. The primary outcome was intensive care unit (ICU) mortality. Secondary outcomes included in-hospital mortality and standardised mortality ratio (SMR). Analyses were stratified by the country income level(s) of each registry.FindingsAmong 1 642 632 non-COVID-19 admissions, there was an increase in ICU mortality between 2019 (9.3%) and 2020 (10.4%), OR=1.15 (95% CI 1.14 to 1.17, p<0.001). Increased mortality was observed in middle-income countries (OR 1.25 95% CI 1.23 to 1.26), while mortality decreased in high-income countries (OR=0.96 95% CI 0.94 to 0.98). Hospital mortality and SMR trends for each registry were consistent with the observed ICU mortality findings. The burden of COVID-19 was highly variable, with COVID-19 ICU patient-days per bed ranging from 0.4 to 81.6 between registries. This alone did not explain the observed non-COVID-19 mortality changes.InterpretationIncreased ICU mortality occurred among non-COVID-19 patients during the pandemic, driven by increased mortality in middle-income countries, while mortality decreased in high-income countries. The causes for this inequity are likely multi-factorial, but healthcare spending, policy pandemic responses, and ICU strain may play significant roles.
Floral and faunal biostratigraphy of the Middle–Upper Triassic Karamay and Huangshanjie formations from the southern Junggar Basin, China
Authors: Peng Jungang , Slater Sam M. , Vajda Vivi 
Published: May 2023

Abstract

In the Junggar Basin, northwestern China, the biostratigraphy and vegetation patterns of the Middle–Late Triassic sediments are comparatively poorly resolved. Here we investigate Middle–Late Triassic successions of the Dalongkou Section in the southern Junggar Basin for palynostratigraphy and vegetation patterns. Three palynological abundance zones are proposed here: the
Aratrisporites
Abundance Zone (Middle Triassic), the
Dictyophyllidites
–
Aratrisporites
Abundance Zone (latest Middle to early Late Triassic) and the
Lycopodiacidites
–
Stereisporites
informal abundance zone (Late Triassic). A review of previous records of the
Fukangichthys
Fauna indicates that this vertebrate fossil assemblage is stratigraphically located within the uppermost part of the Karamay Formation and is Middle Triassic in age. The revised dating of this and other faunas are further used to constrain the palynological zones in the Junggar Basin. Although the palynoflora is consistently dominated by non-striate bisaccate pollen (produced by seed ferns and/or conifers) in the studied section, spores record a distinctive abundance increase during the late Middle Triassic. Spore taxon abundance changes indicate a vegetational shift from a Middle Triassic–early Late Triassic community characterized by abundant lycophytes (likely
Annalepis
and
Pleuromeia
) to a Late Triassic ecosystem with abundant dipteridaceous ferns (e.g.
Dictyophyllum
) in the Junggar Basin and across North China. This study updates the Triassic biostratigraphy in the Junggar Basin, and sheds light on temporal floral changes in this basin and elsewhere in North China during the Middle to Late Triassic.
Design and Development of Parasitic Elements Loaded Quadband Frequency and Pattern Reconfigurable Antenna
Authors: Karthika K. , Kavitha K. 
Published: May 2023

Modern communication demands a low-profile, versatile antenna. In this paper, a low-profile antenna of size

38
×
40
×
0.787

m

m

3

is proposed to reconfigure frequency and radiation pattern. The Rogers RT Duroid 5870 of dielectric constant 2.33 is used as a substrate. Frequency reconfiguration is achieved by connecting patches of different lengths corresponding to the resonant frequencies through three PIN diode switches. Switching on/off these three diodes results in frequency switching between four distinct frequency bands. The Yagi-Uda principle is utilized to alter the radiation pattern. Simple parasitic elements are loaded on either side of the radiating structure. Changing the electrical lengths of the parasitic elements using PIN diode switches facilitates pattern reconfiguration by making them behave as a reflector/director. The presented structure resonates at four distinct frequencies (5.3 GHz/3.82 GHz/2.77 GHz/2.2 GHz) with a maximum of three beam tilt angles for each resonating frequency. SMP1345-079LF PIN diode is used for switching operation. Biasing circuit has been designed to ensure RF and DC isolation. The proposed antenna offers acceptable radiation performance in all the switching states. The average measured gains are 2.43 dBi, 2.42 dBi, 3.5 dBi, and 3.29 dBi at 5.3 GHz, 3.82 GHz, 2.77 GHz, and 2.2 GHz, respectively. On an average, the proposed antenna exhibits the simulated efficiency of 81%. The proposed antenna is suitable for 5G communication as its bandwidth covers band 1, band 7, band 46, and band 77 of the 5G new radio (NR) standard. Fabrication and testing are done to validate the results.