bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac hemodynamic responses to exercise training in patients with coronary heart disease
Authors: Kirsch M K , Vitiello D V , Trachsel L D T , Boidin M B , Lalonge J L , Juneau M J , Bherer L B , Nigam A N , Gayda M G 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
In coronary heart disease (CHD) patients, tailored training programs are strongly recommended to decrease cardiovascular mortality but factors responsible for a positive response to training remain unclear.
The aim of this study was to compare cardiac hemodynamic parameters changes after a training program in CHD patients, according to the training responder’s status.

Methods
72 CHD patients (78% males, 63±9y) were recruited to perform a 12-week training consisting in a combination of endurance and endurance sessions.
Patients underwent 2 cardiopulmonary exercise testing (CPET) using a ramp protocol (10 to 15 W/min) on a cycle ergometer pre- and post-training. Hemodynamic parameters (e.g., cardiac output (CO), cardiac index (CI), stroke volume (SV), systemic vascular resistance (SVR)) were measured by bioimpedance, and CPET parameters (e.g., peak oxygen uptake (O2peak)) were also measured pre- and post-training.

Results
Patients were divided in 2 groups (responders-R and non-responders-NR) according to the median change in O2peak.
In the R group, O2peak (+16.8%, p &lt; 0.001), CO, CI and SV increased by16.6%, 16.8% and 13.0%, respectively (p &lt; 0.01) after the training program. In the NR group, O2peak, CO, CI and SV increased by 0.48%, 5.12%, 8.07% and 5.75%, respectively (p &lt; 0.01). The SVR decreased in both groups (-19.0% in R and -11.4% in NR, p &lt; 0.001).

Conclusion
The R group of CHD patients showed better improvement in cardiac hemodynamic and CPET parameters after a 12-week training program than NR. Further studies are needed to determine the best way to individualize training programs for the non-responders.
Changes in muscle strength and muscle mass after transcatheter aortic valve implantation (TAVI)
Authors: Van Erck D , Dolman C D , Scholte Op Reimer W J M , Henriques J P , Weijs P J M , Schoufour J D , Delewi R 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public hospital(s). Main funding source(s): Amsterdam UMC.

Background
Maintenance of muscle strength and muscle mass is important for long-term health. Periods of physical inactivity and poor dietary intake (e.g. waiting for a medical procedure) can provoke loss of muscle strength and muscle mass.

Purpose
We aim to determine the course of muscle strength and muscle mass in patients with severe aortic stenosis from before until six months after an elective transcatheter aortic valve implantation (TAVI). Moreover, we aim to explore baseline characteristics associated with change.

Methods
All patients undergoing an elective TAVI in our high-volume tertiary center were asked to participate. Included patients received three home visits (pre-procedural and 30 days and 6 months post-procedural). During these home visits, handgrip strength was measured with a handheld dynamometer. Muscle mass was determined as skeletal muscle index with a bioelectrical impedance (BIA) measurement. Multivariate mixed linear models were used to determine changes over time. A linear model adjusted for age and sex was performed to explore baseline characteristics associated with changes in muscle strength or muscle mass.

Results
In total 112 patients were included, mean age of the participants was 81 ± 5 years and 58% were male. The preprocedural measurement took place on a median of 48 [IQR: 19 – 79] days before the TAVI. Preprocedural handgrip strength was on average 36 kg for male and 24 kg for female patients and decreased after the TAVI (-0.12 [95% CI: -0.21, -0.02] kg/month, p=0.02). Living alone and lower hemoglobin level were predictive for a higher decrease in strength (β -2.20 [95% CI: -3.98, -0.42], p=0.02 and β 0.14 [95% CI: 0.02, 0.27] per mmol/l, p=0.03, respectively). Appendicular skeletal muscle index was 7.2 kg/m2 for males and 6.1 kg/m2 for females and did not change after TAVI (0.00 [95%CI: -0.01, 0.01] kg/m2/month, p=0.95). No baseline characteristics were associated with a change in muscle mass.

Conclusion
Muscle strength significantly declines and muscle mass remains the same from before until six months after the TAVI procedure. Patients living alone or patients with low hemoglobin levels are at increased risk to lose muscle strength. Future studies should focus on the prevention of strength loss, for instance with interventions focusing on nutrition and exercise around the TAVI procedure.
Assessment of physical activity in out-of-hospital cardiac arrest survivors: a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
Authors: Heimburg K , Lilja G , Blennow Nordstrom E , Gregersen Ostergaard L , Grejs A M , Keeble T R , Mion M , Rylander C , Segerstrom M , Thomsen I K , Ullen S , Unden J , Wise M P , Cronberg T , Tornberg A B 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Foundation. Main funding source(s): Riksförbundet HjärtLung Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research.

Background
Low physical activity is a risk factor for new cardiac events in out-of-hospital cardiac arrest (OHCA) survivors. Physical activity could be assessed by both self-reports and objective accelerometer data.

Aim
To investigate the coherence between self-reported and objectively assessed physical activity among OHCA survivors.

Method
Cross-sectional study including OHCA survivors in Sweden, Denmark and the United Kingdom. Two questions about moderate- and vigorous-intensity physical activity during the last week were used as self-reports. Additionally, moderate- and vigorous-intensity physical activity were objectively assessed with an accelerometer (ActiGraph wGT3X BT) worn at the waist for seven consecutive days.

Results
49 of 106 included OHCA survivors had answered the two questions and had seven valid days of accelerometer assessment and were included in the analyses. According to self-reports, the median of moderate-intensity physically active days was 5 [3:7] and vigorous-intensity physically active days was 1 [0:3] during the week wearing the accelerometer. Assessed by accelerometery, the median of moderate-intensity physically active days was 3 [1:5] and vigorous-intensity physically active days was 0 [0:0] . Correlations between self-reported and objectively assessed moderate- and vigorous-intensity physical activity were sufficient (rs=.336, p=0.018) and (rs=.375, p=0.008) and agreements were fair (k=0.269, p=0.001) and slight (k=0.148, p=0.015).

Conclusion
Self-reported and objectively assessed moderate- and vigorous-intensity physical activity correlated but the agreements were only slight to fair indicating that researchers need to exert caution when interpreting results from physical activity questionnaires.
Risk of atherosclerotic cardiovascular disease in patients with premature ASCVD: A study from approximately 1 million young adults
Authors: Rana J , Liu J , Moffet H , Nasir K , Mamas M , Blankstein R , Karter A , Sidney S 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Risk of atherosclerotic cardiovascular disease (ASCVD) attributable to premature ASCVD remains poorly understood.

Purpose
To evaluate the risk of ASCVD among those with premature ASCVD versus those without in a large contemporary population.

Methods
This observational cohort study included young adults (ages 30-55 years) with and without prior ASCVD (as of January 1, 2006) who were members of an integrated healthcare delivery system in Northern California. Adjusted multivariate models were specified to estimate risk ratios (RRs) for incident ASCVD events by ASCVD status at baseline. Incident ASCVD events were defined as a composite of nonfatal myocardial infarction, ischemic stroke, or coronary heart disease death through December 31, 2020.

Results
A total of 929,214 individuals met the selection criteria of no prior ASCVD and 5,703 with prior ASCVD. Mean age was 43.9 (±7.3) years and 50.0 (±5.2) years, respectively. Fifty-two and thirty percent were women in each cohort, and the median follow-up was 11.8 and 8.3 years, respectively. Crude ASCVD rate was 2.1 and 24.5 events per 1,000 person-years, respectively. Age-adjusted Kaplan-Meier curves for ASCVD in individuals with and without prior ASCVD in Figure. In models adjusted for demographics (sex, age, race) and traditional risk factors (diabetes, hypertension, LDL-cholesterol, HDL-cholesterol, total cholesterol, smoking), individuals with prior ASCVD had RR of 4.6 (95% CI 4.3-5.0) for CHD, RR of 3.0 (95% CI 2.7-3.4) for stroke and RR of 4.1 (95% CI 3.8-4.3) for ASCVD.

Conclusions
Risk of ASCVD among those with prior ASCVD was several-fold greater compared to those without prior ASCVD. Continued efforts for secondary prevention are needed in this vulnerable high-risk population.
DAHNA-An integrated innovative mobile application for the screening and management of the atherosclerotic cardiovascular disease risk
Authors: Tatu-Chitoiu G , Damian S , Weiss E , Mocanu I , Patrascu M , Dragoi P , Tatu-Chitoiu D 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.
Backgrond: DAHNA (Diet According to the Healthy Heart Nutritional Approach) is an integrated innovative free mobile app that allows:1.Screening of the atherosclerotic cardiovascular diseases (ASCVD) risk. 2.Personalized healthy diet based on the cardiometabolic screening. 3.Personalized advice and referral to doctors for those with a high/very high risk score. 4. Long-term following of the major risk factors.

Objective
Presentation of DAHNA functionalities, operation mode and first results through public implementation.

Methods
DAHNA can be downloaded on any mobile phone regardless of its operating system. Functionalities:ASCVD risk score assessment by an „all-in-one-for-all" risk calculator joining the 2021 European Society of Cardiology (ESC) SCORE2/SCORE2-OP scores and the American Heart Association (AHA) Framingham score. When the user mentions his/her country either SCORE2/SCORE2-OP or Framingham opens automatically.For Europe calculation is based on the four SCORE2/SCORE2-OP tables of the four risk regions. DAHNA is not limited to healthy people, but allows the user to mention if he/she already has diabetes, chronic kidney disease or ASCVD. From this moment on, he/she is notified that is at high/very high risk. 2.Based on the ASCVD risk DAHNA offers: 2a. Personalized healthy menus (Mediterranean diet) including the macro and micronutrients in the recommended daily dose.The ingredient list is automatically created with the required quantities.The user can choose between the personal purchase of the ingredients or ordering the list from suppliers 2b.short movies for initiation into physical activity 2c.up-to-date educational medical information. 2d.The need for a quick consultation for those with high/very high risk. 2e.Periodically follow-up of the outcome of the ASCVD risk. All data are collected in a central data base.

Results
Between August 10th, 2022 (when this version was launched) and November 1st, 2022, 15780 users downloaded DAHNA (265 downloads/day, mean age: 48+/-10 years, 58% females; 16% smokers, 18% hypertension. A 100% correspondence between the results of DAHNA calculator and ESC tables was confirmed.

Conclusion
1.DAHNA is the first app to combine the ASCVD risk scores with the assignment of personalized healthy diet, healthy lifestyle advice and periodic risk self-assessment. 2.DAHNA is an universal ASCVD risk mobile calculator 3.DAHNA offers a real-time knowledge and following of the dynamics of the major risk factors and ASCVD risk in large populations. These data should be important for the adjustment of the health policies.
The WALK HOP program: a French innovative multicentric home-based cardiac rehabilitation initiative
Authors: Tomas M C F , Six M M , Pavy B , Guy J M , Nguyen N V 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Fonds pour l'innovation du système de santé (FISS) - France.

Background
Cardiac rehabilitation (CR) has demonstrated scientific benefits in terms of morbidity and mortality. In France, 2019 national data indicates that only 22,3% of coronary patients benefit from CR. The development of alternative programs to center-based cardiac rehabilitation (CBCR) must be considered as a public health priority and requires a reorganization of ambulatory care pathways.

Purpose
The objective of the "Walk Hop" program is to demonstrate that home-based cardiac tele-rehabilitation (HBCT) is a complementary and safe approach to CBCR, able to increase the proportion of patients benefiting from a rehabilitation program.

Methods
This feasibility study started begin of 2022. 3,200 coronary patients will be recruited in 8 participating cardiac rehabilitation centers (CRC). Total duration of the experiment is 42 months. The program is financially supported by the French authorities.
The HBCT solution developed for the study is proposed to patients by the CRC cardiologist. A multidisciplinary platform consisting of a secure portal and an application allows bidirectional communication. Patients are equiped with a cycle ergometer and a validated heart rate monitor. The application presents aerobic and muscle strenghtening activities and therapeutic education and collects data from the sessions carried out, adherence to the program, symptoms and quality of life.

Results
By october 2022, 157 active patients have been included in the program with a large majority of men (86%). Mean age is 53,9 ± 9,0. Hypercholesterolemia is noted in 36,9% of the included patients, smoking in 31%, arterial hypertension in 30,6% and diabetes in 11,1%. Obesity/overweight affects 60% of the population. Mean time from angioplasty to initiation of the rehabilitation is 81 ± 90 days. Mean number of home rehabilitation sessions is 21 and a total of 3342 home sessions have been realized. No cardiovascular event or rehospitalization have been registered since the beginnng. Mean adherence to the prescribed sessions is 80 ± 20% and the mean power gain at the end of the program is 14,6 ± 9,9 %.
94% of the patients expressed satisfaction or high satisfaction at the end of the program.

Conclusion(s)
The Walk Hop program is evaluating the feasibility and acceptability of HBCT with remote monitoring and digital assistance by smartphone. The preliminary data are encouraging in view of the final expected impact: greater cost-effective access to rehabilitation programs by removing obstacles like distance or resumption of work. It is also expected that HBCT will provide an improvement in the long-term maintenance benefits.
Comparison of radial artery occlusion occurrence (RAO) between compression band device and manually applied gauze compression after transradial coronary procedure, a PROBE study
Authors: Ramos H J R , Marcelo J 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Hemostasis of the radial artery after transradial coronary procedure can be achieved either manually by means of a gauze or mechanically through a device compression band, and radial artery occlusion (RAO) is one of its common complications.

Purpose
The study sought to compare the occurrence of RAO between the two hemostasis methods being used after a transradial coronary procedure to determine an effective and safe method that can be recommended for use.

Methodology
This was a Prospective, Randomized Open-label Blinded Endpoint (PROBE) study. A total of 137 patients undergoing a transradial coronary procedure were randomized equally using block randomization sampling technique. Radial artery patency was evaluated by color duplex ultrasonography within 24-72 hours after the procedure. The primary endpoint was early RAO. Secondary endpoints included complications such as access-site bleeding, pain, and hematoma.

Results
Three (2.19%) early RAOs occurred, 1 (1.47%) in the band compression device group and 2 (2.9%) in the manual gauze compression group (p= 1.000). There were no significant differences between the 2 groups regarding access-site bleeding [type 1 bleeding, 3 (4.48%) vs 2 (2.90%); p= 0.678]; pain with median pain score of 0 (0-6) vs 0 (0-7); p= 0.742; and hematoma [Grade I: 3 (4.41%)vs 2 (2.9%); Grade II: 0 vs 2 (2.9%); Grade III: none, and Grade IV: 0 vs 2 (2.9%); p= 0.363].

Conclusion
Compression Band Device and Manually Applied Gauze Compression have similar rates of early RAO, access-site bleeding, pain, and hematoma.
Are there gender differences in diagnostic and therapeutic sports cardiology care? Data from one sports cardiology centre
Authors: Jiravsky O , Pesova P , Krausova D , Pleva M , Spacek R , Sknouril L , Jiravska Godula B 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Cardiovascular care of highly active individuals and competitive athletes has become an important topic in the field of sports medicine. The evolving understanding of exercise-induced cardiovascular remodeling in athletes has led to a more thorough characterization of physiological adaptation versus pathological dysfunction, but this distinction is often challenging because of diagnostic commonalities. The current data reflect sport-specific analyses of predominantly male athletes that may not be readily applicable to the female athletic heart. Another aspect of this care may be the different approach to indication, interpretation, and referral between men and women.

Objective
To determine whether there is a difference between men and women in access to sports cardiac care. Whether there is a difference between the indicated investigations, therapeutic care and recommendations made.

Methods
Retrospective analysis of the registry of all athletes of the Sports Cardiology Centre (SCC). Statistical comparison of the cohort of women and men in all parameters studied.
Cohort: Between 1/2020-6/2022, a total of 115 cases of athletes, 100 men and 15 women (13%), aged 26 (+/-11 years), were examined and definitively closed in the SCC. Demographics in Table No. 1.

Results
There were no statistically significant differences in indications, symptoms, examination methodologies, percentage of diagnosis or eligibility for sport from a cardiological perspective. The only statistically significant difference seen was in the higher percentage of women taking regular pharmacological medication (hormonal contraception was not included in this category) - namely 40% of women taking regular medication vs. 60% of women without medication vs. 85% of men without regular medication vs. 15% with regular medication (p=0.019). The differences in parameters across categories are summarized in Table No. 2.

Conclusion
Except for the total number of men and women screened, we do not see a significant difference in indication, screening, diagnosis and eligibility proposal between genders.
The role of the arrhythmologist in a sports cardiology centre: the devil is in the detail
Authors: Jiravsky O , Pesova P , Spacek R , Krausova D , Pleva M , Miklik R , Sknouril L , Jiravska Godula B 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
The role of the arrhythmologist in a sports cardiology centre (SCC) is to provide comprehensive care to athletes with cardiac arrhythmias.

Objective
To determine the proportion of athletes with arrhythmias examined at a SCC. To define the differences in care between an athlete with and without arrhythmia.

Methods
Retrospective analysis of the registry of all athletes of one SCC. Identification of patients=athletes with arrhythmias, description of key differences in access to arrhythmology subunits.
Cohort: Between 1/2020-6/2022, a total of 115 cases of athletes, 100 males and 15 females (13%), aged 26 (+/-11 years), were examined and definitively closed at SCC. Twenty-two athletes (19%) received care for cardiac rhythm disorders. Duration of sports activity was at the borderline of statistical significance in demographic parameters (see Table No. 1), with 15 (+/-11) vs 12 (+/-8) years for athletes with non-arrhythmic diagnoses (p=0.085).

Results
In the statistical comparison of the groups without and with arrhythmias (Table No. 2), we see a statistically significantly higher proportion of athletes presenting because of symptoms and with pathological findings of the pre-participation screening, with a higher proportion of family history of sudden cardiac death, with a higher proportion of coronary CT use and an extraordinary statistical significance of cardiac MRI use. Conversely, there is no statistically significant difference in diagnosis and impact on sports eligibility.
The sports cardiologist must be particularly cautious in the diagnosis and treatment of ventricular extrasystoles, which have a different "diagnostic-eligibility" pathway for athletes. Similarly, they must listen to the medical history more than non-athletes and be willing and able to use various sports monitor records.
In invasive methods of diagnosing and treating arrhythmias, it is necessary to understand when arrhythmias occur in real life and try to mimic the diagnostic conditions of this situation (e.g., when inducing clinical arrhythmias that an athlete has in real life during the peak moments of a match or race). Last but not least, the sports cardiologist must communicate the potential changes that may occur by ablative treatment of the arrhythmia (e.g., a decrease in maximal heart rate after AVNRT ablation on the so-called slow pathway, or, e.g. a possible increase in resting heart rate after pulmonary vein isolation with radiofrequency or laser energy).

Conclusion
Athletes with arrhythmias are different in many aspects, and the role of the arrhythmologist in the sports cardiology team is to be prepared to respect these differences in an effort to provide the best possible care for the athlete.