bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the clinical efficacies of two L‐asparaginase‐based chemotherapy regimens for newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma
Authors: Wu Wanchun , Ren Kexin , Chen Xi , Li Na , Luo Qian , Hai Tao , Zhou Huijie , Zou Liqun 
Published: March 2023

AbstractBackgroundNasal‐type extranodal natural killer (NK)/T cell lymphoma (ENKTL) is a rare and aggressive type of lymphoma. The optimal chemotherapy regimen for ENKTL has not yet been established. In this study, we compared the LVDP (L‐asparaginase, etoposide, dexamethasone, and cisplatin) and GLIDE (gemcitabine, L‐asparaginase, ifosfamide, dexamethasone, and etoposide) chemotherapy regimens for the treatment of ENKTL.MethodsA total of 267 patients with newly diagnosed ENKTL were included in this retrospective study. Propensity score matching (PSM) was used to adjust for confounders between the LVDP and GLIDE groups. Treatment responses, survival outcomes, and toxicities between the two groups were compared before and after PSM.ResultsAt the end of therapy, the objective response rate (ORR) and complete response (CR) were 83.5% and 62.2%, respectively, for all patients. The ORR and CR were 85.5% and 62.2% for the LVDP group compared with 79.3% and 62.2% for the GLIDE group, respectively, and no differences between the two groups were found (ORR, p = 0.212; CR, p = 0.996). With a median 71 months follow‐up, the 5‐year progression‐free survival (PFS) and overall survival (OS) rates were 64.3% and 68.5%, respectively. The 5‐year PFS and OS were 65.6% and 70.1% for the LVDP group compared with 61.6% and 64.6% for the GLIDE group, respectively (PFS, p = 0.478; OS, p = 0162). After PSM, no significant differences in short‐term efficacy (ORR, p = 0.696; CR, p = 0.264) or long‐term efficacy (PFS, p = 0.794; OS, p = 0.867) between the two groups were identified. However, treatment‐related toxicities were milder in the LVDP group compared to the GLIDE group, even after adjusting for confounders via PSM.ConclusionIn conclusion, both LVDP and GLIDE regimens are effective for the treatment of ENKTL. However, the LVDP regimen is safer than the GLIDE regimen, with milder treatment‐related toxicities. Therefore, the LVDP regimen could be a preferable option for patients with ENKTL.
Human papillomavirus testing on self‐collected samples to detect high‐grade cervical lesions in rural Bhutan: The REACH‐Bhutan study
Authors: Clifford Gary M. , Baussano Iacopo , Heideman Daniëlle A. M. , Tshering Sangay , Choden Tashi , Lazzarato Fulvio , Tenet Vanessa , Franceschi Silvia , Darragh Teresa M. , Tobgay Tashi , Tshomo Ugyen 
Published: March 2023

AbstractBackground“REACH‐Bhutan” aimed to evaluate the feasibility and clinical performance of a community‐based screening program for cervical cancer in rural Bhutan using self‐collected samples for high‐risk human papillomavirus (HR‐HPV) testing.MethodsIn April/May 2016, 2590 women aged 30–60 years were screened across rural Bhutan by providing a self‐collected sample for careHPV testing. All careHPV‐positive women, plus a random sample of careHPV‐negative women, were recalled for colposcopy and biopsy. Self‐samples also underwent GP5+/6+ polymerase chain reaction (PCR)‐based HR‐HPV DNA detection and genotyping. Cross‐sectional screening indices were estimated against histological high‐grade squamous intraepithelial lesions or worse (hHSIL+), including imputation of hHSIL+ in women without colposcopy.ResultsHR‐HPV positivity was 10.2% by careHPV and 14.8% by GP5+/6+ PCR. Twenty‐two cases of hHSIL+ were histologically diagnosed, including one invasive cancer; an additional 7 hHSIL+ were imputed in women without colposcopy. HR‐HPV testing by GP5+/6+ showed higher sensitivity for hHSIL+ (89.7%, 95% CI 72.6–97.8) than careHPV (75.9%, 95% CI 56.5–89.7). Negative predictive value was also slightly higher for GP5+/6+ (99.9%, 95% CI 99.6–100) than careHPV (99.7%, 95% CI 99.4–99.9). Specificity, however, was lower for GP5+/6+ (86.1%, 95% CI 84.6–87.4) than careHPV (90.6%, 95% CI 89.4–91.7), as was positive predictive value (6.9%, 95% CI 4.5–9.9 vs. 8.5%, 95% CI 5.4–12.6). Of 377 HR‐HPV‐positive women by GP5+/6+, 173 (45.9%) were careHPV‐positive, including 54.7% HPV16‐positive and 30.2% HPV18‐positive women.ConclusionsThe final REACH‐Bhutan results show that screening for cervical cancer with self‐collection of samples and HR‐HPV testing, in addition to our previous report of achieving high participation, can also perform well to detect women with hHSIL+.
Encapsulated papillary carcinoma of the breast: An institutional case series and literature review
Authors: Tan Hiang Jin , Tan Puay Hoon , Leong Lester Chee Hao , Tan Veronique Kiak Mien , Tan Benita Kiat Tee , Lim Sue Zann , Preetha Madhukumar , Wong Chow Yin , Yong Wei Sean , Sim Yirong 
Published: March 2023

AbstractBackgroundEncapsulated papillary carcinoma of the breast is rare, making difficult diagnosis and resulting in patients undergoing excision biopsy before definitive surgery. Evidence‐based guidelines are sparse. We would like to further elucidate the clinicopathological, treatment and survival outcomes.Materials and Methods54 patients identified, with a median follow up duration of 48 months. Patients' demographics, radiological and clinicopathological characteristics, treatment, adjuvant therapies as well as survival data were analysed.Results18 (33.3%) cases were pure EPC, 12 (22.2%) were EPC associated with ductal carcinoma in situ (DCIS) and 24 (44.4%) cases had concurrent invasive ductal carcinoma. EPCs were more likely to present as a solid‐cystic mass on sonography (63.8%), regular‐shaped (oval or round) (97.9%), lack spiculations (95.7%) and lack suspicious microcalcifications (95.6%). Median tumour size was largest in the EPC with IDC group (18.5 mm). 2 patients developed loco‐regional recurrence. Overall survival is good for EPCs of all subtypes.ConclusionEPC is a rare tumour with excellent prognosis.
Cost‐effectiveness of second‐line ipilimumab for metastatic melanoma: A real‐world population‐based cohort study of resource utilization
Authors: Lu Brandon , Dai Wei Fang , Croxford Ruth , Isaranuwatchai Wanrudee , Beca Jaclyn , Menjak Ines B. , Petrella Teresa M. , Mittmann Nicole , Earle Craig C. , Gavura Scott , Mercer Rebecca E. , Hanna Timothy P. , Chan Kelvin K. W. 
Published: March 2023

AbstractBackgroundThe efficacy‐effectiveness gap between randomized trial and real‐world evidence regarding the clinical benefit of ipilimumab for metastatic melanoma (MM) has been well characterized by previous literature, consistent with initial concerns raised by health technology assessment agencies (HTAs). As these differences can significantly impact cost‐effectiveness, it is critical to assess the real‐world cost‐effectiveness of second‐line ipilimumab versus non‐ipilimumab treatments for MM.MethodsThis was a population‐based retrospective cohort study of patients who received second‐line non‐ipilimumab therapies between 2008 and 2012 versus ipilimumab treatment between 2012 and 2015 (after public reimbursement) for MM in Ontario. Using a 5‐year time horizon, censor‐adjusted and discounted (1.5%) costs (from the public payer's perspective in Canadian dollars) and effectiveness were used to calculate incremental cost‐effectiveness ratios (ICERs) in life‐years gained (LYGs) and quality‐adjusted life years (QALYs), with bootstrapping to capture uncertainty. Varying the discount rate and reducing the price of ipilimumab were done as sensitivity analyses.ResultsIn total, 329 MM were identified (Treated: 189; Controls: 140). Ipilimumab was associated with an incremental effectiveness of 0.59 LYG, incremental cost of $91,233, and ICER of $153,778/LYG. ICERs were not sensitive to discounting rate. Adjusting for quality of life using utility weights resulted in an ICER of $225,885/QALY, confirming the original HTA estimate prior to public reimbursement. Reducing the price of ipilimumab by 100% resulted in an ICER of $111,728/QALY.ConclusionDespite its clinical benefit, ipilimumab as second‐line monotherapy for MM patients is not cost‐effective in the real world as projected by HTA under conventional willingness‐to‐pay thresholds.
Long‐term follow‐up results of spine tumor treatment using high‐dose radiotherapy after 3‐dimensional‐printed vertebral bodies implantation
Authors: Xiao Yao , Wang Yuxia , Wei Feng , Zhuang Hongqing 
Published: March 2023

AbstractObjectiveTo investigate the long‐term safety and efficacy of high‐dose radiotherapy after 3D‐printed vertebral body implantation in the treatment of spinal tumors.MethodsThirty‐three participants were recruited between July 2017 and August 2019. 3D‐printed vertebral bodies were implanted in each participant, followed by postoperative robotic stereotactic radiosurgery at a dose of 35–40 Gy/5f. The tolerance of the 3D‐printed vertebral body and the participant to the high‐dose radiotherapy were evaluated. In addition, the local control of tumor and the local progression‐free survival of the study participants following 3D‐printed vertebral body implantation and high‐dose radiotherapy were measured as indexes of effectiveness.ResultsOf the 33 participants included in the study, 30, including three participants (10%) with esophagitis of grade 3 or above and two participants (6.7%) with advanced radiation nerve injury, successfully underwent postoperative high‐dose radiotherapy. The median follow‐up was 26.7 months, and IQR was 15.9 months. Most participants had primary bone tumors with 27 cases (81.8%), and the rest had bone metastases in six cases (18.2%). After high‐dose radiotherapy, the 3D‐printed vertebrae maintained good vertebral stability and exhibited histocompatibility, without implant fractures. The local control rates were 100%, 88%, and 85% 6 months, 1 year, and 2 years after high‐dose radiotherapy, respectively. Tumors recurred in four participants (12.1%) during the follow‐up period. The median local progression‐free survival after treatment was 25.7 months, with a range of 9.6–33.0 months.ConclusionHigh‐dose radiotherapy for spinal tumors after 3D‐printed vertebral body implantation is feasible, elicits low toxicity, and yields satisfactory tumor control.
Characteristics of endoplasmic reticulum stress in colorectal cancer for predicting prognosis and developing treatment options
Authors: Geng Jingbo , Guo Yunkai , Xie Mingjie , Li Zhipeng , Wang Peng , Zhu Donghui , Li Jing , Cui Xiaopeng 
Published: March 2023

AbstractBackgroundAn increasing body of evidence supports an essential role for endoplasmic reticulum stress (ERS) in colorectal cancer (CRC). In this study, we developed an ERS‐related genes (ERSRGs) model to aid in the prognostic evaluation and treatment of CRC patients.MethodsThe training set and validation set data were extracted from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), respectively. ERSRGs were obtained from the GeneCards database. A prognostic risk scoring model was constructed using the least absolute shrinkage and selection operator (LASSO) along with univariate Cox regression analysis. To further predict the probability of survival for patients at 1, 2, and 3 years, a nomogram was devised. The advantages of the prognostic risk score model in screening patients’ sensitive to chemotherapy and immunotherapy were analyzed by drug sensitivity analysis and immune correlation analysis. Finally, hub genes associated with poor prognosis in the risk model were screened by Protein–protein interaction (PPI) network and their expression was validated using clinical specimens.ResultsA risk model for overall survival (OS) was developed using 16 ERSRGs associated with prognosis. Through analyses, we demonstrated a high degree of reliability for the prognostic risk scoring model. The constructed nomograms performed well in predicting patient survival over 1, 3, and 5 years. The calibration curve and decision curve analysis (DCA) supported a high degree of accuracy for the model. Patients in the low‐risk group had a lower IC50 for the common chemotherapy drug, 5‐FU, and responded better to immunotherapy. hub poor prognostic genes were validated in CRC clinical specimens.ConclusionWe have identified and validated a new ERS prognostic marker that can accurately predict the survival status of CRC patients for clinicians and better provide personalized treatment plans.
Efficacy and safety of TACE combined with lenvatinib and PD‐1 inhibitors for unresectable recurrent HCC: A multicenter, retrospective study
Authors: Wang Wei‐Jun , Liu Zong‐Han , Wang Kang , Yu Hong‐Ming , Cheng Yu‐Qiang , Xiang Yan‐Jun , Feng Jin‐Kai , Zhou Li‐Ping , Zhou Hong‐Kun , Pan Wei‐Wei , Guo Wei‐Xing , Shi Jie , Cheng Shu‐Qun 
Published: March 2023

AbstractBackgroundThere is no consensus on the optimal regimen for unresectable recurrent hepatocellular carcinoma (HCC), so this retrospective study aimed to evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib and PD‐1 inhibitors (T‐L‐P) versus TACE combined with lenvatinib (T‐L) or TACE alone.MethodData were collected from 204 patients with unresectable recurrent HCC who received T‐L‐P, T‐L, or TACE alone at three medical centers from January, 2019 to December, 2020 for analysis. The survival outcomes, tumor response, and adverse events were compared between three groups, and risk factors were further investigated.ResultsThe median overall survival in the T‐L‐P, T‐L, and TACE alone groups were not reached, 25.6, and 15.7 months, respectively (p < 0.001). The median progression‐free survival in the T‐L‐P, T‐L, and TACE alone groups were 24.1, 17.3, and 13.7 months, respectively (p < 0.001). The best objective response rate in the T‐L‐P, T‐L, and TACE alone groups were 70.4%, 48.9%, and 42.5%, respectively. The best disease control rate in the T‐L‐P, T‐L, and TACE alone groups were 100.0%, 97.8%, and 87.5%, respectively. There was no significant difference between the T‐L‐P and T‐L groups for Grade 3/4 adverse events.ConclusionT‐L‐P regimen was safe and superior to T‐L or TACE alone in improving survival for unresectable recurrent HCC patients.
The Study of Impedance and Conductivity of New Modified Polystyrene Used as an Effective Adsorbent of Ba(II) Ions
Authors: Smida Nourhene Ben , Abdelhak Othmani , Raoudha Abderrahim 
Published: March 2023

AbstractIn the research described here we prepared a novel, modified polystyrene (PS) with iminoether as the complexing agent for Ba2+. Most heavy metals cause environmental, atmospheric pollution.[1–2] They cause consequence for humans health and aquatic life due to their toxicity. They become strongly toxic by mixing with different environmental elements and their removal from contaminated water is very important. The structure of all modified polystyrene such as nitrated polystyrene (PS−NO2), aminated polystyrene (PS−NH2), aminated polystyrene with imidate group (PS−NH−Im) and the complex with barium metal (PS−NH−Im/Ba2+) were analyzed by Fourier transform infrared spectroscopy (FT‐IR), and the formation of N‐2‐Benzimidazolyl iminoether grafted PS was proved. The thermal stability and structure of the polystyrene and modified polystyrene were studied by differential thermal analysis (DTA) and X‐ray diffractometry (XRD), respectively. The elemental analysis was used for the determination of the chemical composition of the modified PS. The grafted polystyrene was used in order to adsorb barium from wastewater with an acceptable cost before the wastewater distribution in the environment. The impedance analysis of the polystyrene complex PS−NH−Im/Ba2+ indicated an activated thermal conduction mechanism.The conductivity analysis of the complex with barium metal PS−NH−Im/Ba2+ was studied; the activation energy was deduced from an Arrhenius plot and corresponded to,
, suggesting PS−NH−Im/Ba2+ was a proton‐type of semiconductor.
Cytotoxic Terpenes from the Flowers of Inula japonica against Human Hepatocarcinoma Cells
Authors: Wang Tianpeng , Chen Tianyang , Zhang Qiang , Cheng Yexin , Xie Chunfeng , Zhang Quan , Ding Yahui 
Published: March 2023

AbstractTwo new 1,10‐seco‐eudesmanolides (1 and 2) were isolated from the flowers of Inula japonica together with two eudesmanolide analogs (3 and 4) and two monoterpene derivatives (5 and 6). Their structures were established on the basis of detailed spectroscopic analyses and electronic circular dichroism data. All isolates were evaluated for their antiproliferative activities against human hepatocarcinoma HepG2 and SMMC‐7721 cells. Japonipene B (3) exhibited the most potent effect with the IC50 values of 14.60±1.62 and 22.06±1.34 μM against HepG2 and SMMC‐7721 cells, respectively. Furthermore, japonipene B (3) showed significant efficacies of arresting the cell cycle at the S/G2‐M stages, inducing mitochondria‐mediated apoptosis, and inhibiting cell migration in HepG2 cells.
Necrotizing pneumonia due to Pseudomonas aeruginosa secondary to severe COVID‐19 pneumonia
Authors: Hirai Jun , Mori Nobuaki , Asai Nobuhiro , Mikamo Hiroshige 
Published: March 2023

AbstractNecrotizing pneumonia (NP) can occur as a secondary infection even if the clinical course of COVID‐19 pneumonia is favorable, particularly in patients on mechanical ventilation and under immunosuppression.
Construction of Polymeric DNA Network and Application for Cell Manipulation
Authors: Chang Lele , Zhang Rui , Wang Jing , Yao Chi , Yang Dayong 
Published: March 2023

Comprehensive SummaryDeoxyribonucleic acid (DNA) is a biomacromolecule, as well as a polymeric material, whose sequences with different manipulative structures enable them to implement a series of functions, such as reorganization, target, and catalysis. Compared to existing traditional materials incapable of multifunctional integration, the polymeric DNA network is a form of material that can achieve functional integration while maintaining specific DNA properties. Furthermore, precise target enabled by DNA network is one of the most essential components of cellular manipulation. Hence, the DNA network is indispensable and irreplaceable to cell manipulation that it is a versatile tool for the understanding of basic laws of living life and treatments of diseases, such as cell isolation, cell delivery, and cell interference. Herein, the construction of polymeric DNA network is briefly introduced from the aspects of assembly modules, construction methods, and properties. Subsequently, the applications of DNA network in the field of cell manipulation, including cell isolation and encapsulation, intracellular inference and detection, and tumor therapy are summarized. Finally, we provide some prospects for further research and applications of DNA network for cell manipulation.
Mixed Phase Nickel‐Cobaltite for High Energy Density Asymmetric Supercapacitor using Cathodic Overpotential Synthesis Route
Authors: Joshi Ved Prakash , Sahoo Bhanuprakash , Kumar Nitish , Pathak Prakash Kumar , Rath Dharitri , Salunkhe Rahul R. 
Published: March 2023

AbstractFor flexible solid‐state electronics, it is essential to accelerate the transition to renewable materials and environmentally friendly manufacturing procedures. Symmetric supercapacitors (SCs) have a limited voltage window and capacity, hampering their use in practical applications such as portable electronics, hybrid vehicles, and transportation. To improve the energy density of supercapacitors, the strategy of using an advanced pseudo‐capacitive electrode in an asymmetric device configuration is feasible and effective. Here, we report on the design and synthesis of hierarchical honeycomb‐like morphology with controlled Ni/Co molar ratios of NiCo2O4 (NCO) coatings on flexible stainless‐steel substrates utilizing high cathodic overpotential deposition. The NCO electrode retains 90.5% of the three‐electrode capacitance (911 F g−1, or 594 C g−1) even after increasing the current density to 10 A g−1 (∼10 times). Furthermore, we have fabricated a 1.5 V asymmetric supercapacitor (ASC, NCO//AC); such a device delivers maximum specific energy and specific power of 76.8 Wh kg−1 and 16858 W kg−1 in 2 M KOH electrolyte and excellent cycling stability (∼88% retention after 5000 cycles).
Epidemiology of monoclonal gammopathy in Morocco – A hospital‐based study
Authors: Ouzzif Zohra , Doghmi Kamal , Messaoudi Nezha , Bouhsain Sanae , El Machtani Samira , Biaz Asmae , Rachid Achraf , Dami Abdallah , Bezza Ahmed , El Maataoui Aissam 
Published: March 2023

AbstractBackgroundMonoclonal gammopathies are a group of disorders associated with clonal proliferation of plasma cells that produces a monoclonal protein.AimsThe main objective of this study was to describe the epidemiological and immunochemical characteristics of monoclonal gammopathies diagnosed during 19 years in a Moroccan teaching hospital.Materials and ResultsThis retrospective study enrolled 443 Moroccan patients with monoclonal gammopathy, patients meeting the inclusion and exclusion criteria in at the biochemistry department of Military Hospital in Rabat, the capital of Morocco, from January 2000 to August 2019. Of the 443 enrolled patients, 320 (72.23%) were men and 123 (27.77%) were women. All patients were of Caucasian origin, from 12 Moroccan regions. The patient's samples were collected and subjected to serum protein electrophoresis and serum immunofixation electrophoresis to further characterize the monoclonal protein. The mean ± SD age of the 443 participants was 62.24 ± 13.14 years. Reasons for being admitted to the hospital were as follows, bone pain (41.60%), renal failure (19.08%), alteration of the general condition (12.21%), and anemia (10.69). Plasma cell proliferative disorders in our study were as follows, multiple myeloma (MM) (45.65%), Monoclonal gammopathies of undetermined significance (MGUS) (39.05%), Waldenstrom's macroglobulinemia (5.58%), Lymphoma (2.27% + 1.2%), Chronic Lymphocytic Leukemia (2.48%), Plasma cell leukemia (1.86%), Plasmacytoma (0.62%), POEMS syndrome (0.41%), and Amyloidosis (0.84%). The most frequent isotypes in MM were the IgGκ (62) 36.5%, IgGλ (52) 30.6%, IgAκ (27) 15.9%, and the IgAλ (19) 11.2%. It is also worth noting that Free light chain MM represents 20% of all cases of MM.ConclusionsWe found that monoclonal gammopathies are age‐related and affects men more than women, also the results of this study point to the delayed diagnosis of monoclonal gammopathies, since most of our patients were diagnosed at the MM stage. The most frequent isotypes were the IgGκ and IgGλ in MM and MGUS, in Waldenström macroglobulinemia were IgMκ and IgMλ and the oligoclonal profile represented only 3.70%.