bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perencanaan Panti Asuhan Yatim Piatu Di Samarinda Dengan Pendekatan Arsitektur Modern
Authors: Ranna Hyan , Arifin Mahdalena Risnawaty , Tarapandjang Susana Florence 
Published: January 2025

Kurangnya fasilitas panti asuhan untuk menampung anak yatim piatu di Samarinda menurunkan kesempatan untuk anak yatim piatu untuk menyongsong masa depannya karena tiada perlindungan dan jaminan haknya yang terpenuhi. Adanya panti asuhan yatim piatu dapat menjadi solusi bagi permasalahan kurangnya fasilitas dengan menampung anak-anak terlantar tersebut dilengkapi fasilitas pendukung berupa musholla, ruang tidur, ruang kesehatan, ruang belajar, perpustakaan, ruang makan, dapur, dan taman bermain. Tujuan yang diharapkan dari perencanaan panti asuhan ini yaitu dapat sebagai wadah tempat tinggal anak– anak yatim piatu sekaligus sekaligus tempat belajar kegiatan agama Islam secara lebih terarah di Samarinda dengan pendekatan Arsitektur Modern. Manfaat penelitian untuk sebagai dasar dalam penyusunan Acuan Perencanaan yang merupakan bagian tak terpisahkan dalam Tugas Akhir dan referensi mengenai data-data serta studi-studi pendekatan arsitektur modern. Panti Asuhan Yatim Piatu direncanakan menggunakan bentuk persegi dengan penerapan tekstur batu bata dan plester. Unsur arsitektur modern yang diterapkan yaitu menerapkan garis Vertikal dan Horizontal. Direncanakan dengan desain asimetris, sedikit dekorasi, serta Jendela Kaca dan Cahaya Natural. Menggunakan Material dan Sistem Modern, dipadukan dengan bahan bangunan tradisional, dan mengoptimalkan fungsi ruangan. Dipadukan dengan pemanfaatan permukaan luar atap untuk meletakkan solar panel sebagai generator energi listrik berkelanjutan untuk keperluan bangunan.
Accesibilidad cognitiva en investigación biomédica: una mirada desde el Bioderecho
Authors: Cruz Valiño Ana Belén 
Published: January 2025

Introducción: La accesibilidad cognitiva es una demanda histórica que en España ha motivado la adaptación del ordenamiento jurídico por Ley 6/2022 que reforma la Ley General de Derechos de las Personas con Discapacidad para armonizar la legislación a la Convención de Derechos de las Personas con Discapacidad. Metodología: Tras realizar unas precisiones sobre el Bioderecho, se analiza el cambio normativo que permite avances en materia de igualdad como norma de derecho no-discriminatorio. Resultados:. La reforma legal introduce obligaciones jurídicas cuya finalidad es remover las trabas que las personas con dificultades de comprensión y comunicación encuentran en entornos cognitivamente no accesibles. Las barreras de comunicación son especialmente discriminatorias en la investigación biomédica y confirma la premisa de partida: la accesibilidad constituye una condición previa para el ejercicio de los derechos. Discusión: Evaluar si la norma jurídica es conforme a las normas (principios y reglas) recogidas en los derechos fundamentales y su motivación responde a una demanda cívica necesaria. Conclusiones: Permite ilustrar mediante un escenario concreto como la norma jurídica ofrece una respuesta a una situación discriminatoria. Exhibe cómo la Biolegislación propugna un modelo de cuidado de la vida y la salud accesible y sostenible.
PEMANFAATAN WEBSITE SEBAGAI MEDIA INFORMASI DAN KOMUNIKASI PELAYANAN PUBLIK KOTA SURAKARTA
Authors: Debby Kezia Sarfat , Riyanto Buddy , Aji Haryo Kusumo 
Published: January 2025

Pada era informasi digital atau modernisasi pada saat ini, pasokan informasi digital cukup cepat dalam penyebarannya. Informasi tersebut dapat diperoleh secara cepat, efisien, dan lebih akurat. Perkembangan tersebut juga diterapkan oleh Pemerintah Kota Surakarta dalam melakukan pelayanan publik secara online melalui media website. Situs website www.surakarta.go.id ini merupakan representasi dari konsistensi pengetahuan, kapasitas institusi pemerintah untuk berhubungan dengan publik dan semacam media sosialisasi untuk meningkatkan kehidupan sosial. Tujuan dari penelitian ini adalah mengetahui pemanfaatan website www.surakarta.go.id sebagai media informasi dan komunikasi pelayanan publik yang dilakukan oleh Diskominfo Kota Surakarta. Metode yang digunakan dalam penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus yang terfokus pada bagaimana pemanfaatan website sebagai media informasi dan komunikasi pelayanan dalam melaksanakan pelayanan publik di Kota Surakarta. Data yang didapatkan melalui hasil wawancara dengan Staff Diskominfo Kota Surakarta dan Masyarakat Kota Surakarta. Selain itu, data juga didapatkan dengan hasil observasi dan dokumentasi. Hasil penelitian ini dianalisis menggunakan teori Komunikasi Pelayanan Publik menurut Dr. Hardiansyah. Analisis penelitian ini diketahui bahwa Diskominfo SP Kota Surakarta mengembangkan website sebagai media informasi dan komunikasi pelayanan publik. Hasil yang diperoleh dalam penelitian ini ada website sebagai media informasi kepada publik secara online dan menjadi sarana komunikasi antara pemerintah dengan Masyarakat. Dengan adanya website sebagai pelayanan publik ini diharapkan dapat mencukupi serta memudahkan Masyarakat dalam memperolah informasi publik sesuai dengan kebutuhan masing-masing. Tak hanya itu, adanya website ini juga menjadi salah satu bentuk digitalisasi yang dilakukan dalam peningkatan good government bagi pemerintah Kota Surakarta.
Variation of Sago Flour and Tapioca Starch in Carrot (Daucus carota L.) Fortified Mackerel (Scomberomorus commersonii) Sausages
Authors: Andini Monika , Nuraini Vivi , Karyantina Merkuria 
Published: January 2025

Sausage is one of frozen food product thatâ€™s popular among the society. Mackerel is classified as a fish thatâ€™s low fat and higher in protein, and also has characteristics like white meat, thick and didnâ€™t had contain many thorns, so itâ€™s suitable for used in the processed of fish sausage. Innovation of fish sausage can be carried out by fortification provitamin A from carrot paste, and produced gluten-free mackerel sausage product by using sago flour and tapioca starch as a binder. The purpose of this study was to identify Â characteristics of mackerel sausage fortified of carrot paste which is high in protein and Î²-carotene. The experimental design used is a Completely Randomized Design (CRD) with the first factor being the ratio of mackerel and carrot paste 75% : 25%, 50% : 50%, 25% : 75%. The second factor was the ratio of sago flour and tapioca starch as filler of sausage 80% : 20%, 60% : 40%, and 40%: 60%. The analysis indicated that the formulation of mackerel sausage which is highs in protein and the most preferred by consumers is found in the ratio of 75% mackerel : 25% carrot paste and 80% sago flour : 20% tapioca starch with a protein content of 11,36% and an overall level of preference is 3,55 (neutal). The mackerel sausage formulation thatâ€™s highs in Î²-carotene is found in the ratio of 25% mackerel: 75% carrot paste and 60% sago flour: 40% tapioca starch by 876 Âµg/g. Fortified carrot paste in mackerel sausages could be aÂ potensial source of protein and Î²-carotene.
Hubungan Penggunaan Media Sosial, Kualitas Tidur, dan Pola Makan degan Status Gizi Remaja
Authors: Dewi Hesty Yuliana , Aprianti Aprianti 
Published: January 2025

Latar Belakang: Permasalahan gizi yang kerap dialami remaja adalah permasalahan gizi ganda, yaitu gizi kurang dan lebih. Hasil studi pendahuluan di SMAN 2 Martapura ditemukan remaja 16-18 tahun dengan status gizi kategori gemuk sebanyak 50% dan kurus sebanyak 20%. Faktor yang mempengaruhi dikaitkan oleh gaya hidup remaja seperti intensitas penggunaan media sosial tinggi, kualitas tidur buruk dan pola makan kurang yang akan berpengaruh terhadap keseimbangan energi sehingga berdampak terhadap status gizi. Tujuan: Mengetahui hubungan antar variabel pada status gizi remaja di SMAN 2 Martapura. Metode: Jenis penelitian observasional analitik dengan desain cross-sectional. Sampel berjumlah 91 remaja yang dipilih dengan teknik proportionate stratified random sampling. Analisis data dilakukan dengan korelasi Rank Spearman. Hasil: Remaja yang mengakses media sosial dengan intensitas tinggi (53,8%), kualitas tidur buruk (67%), pola makan kurang (53,8%) dan status gizi normal (39,6%). Kesimpulan: Ada hubungan antara intensitas penggunaan media sosial dengan status gizi remaja (r = 0,010), tidak ada hubungan antara kualitas tidur dengan status gizi remaja (r = 0,086), ada hubungan antara pola makan dengan status gizi remaja (r = 0,007). Disarankan remaja menerapkan gaya hidup seperti mengurangi durasi dan frekuensi penggunaan media sosial, memperbaiki kebiasaan tidur serta menjaga pola makan dengan makanan bergizi seimbang.
Perbandingan Metode Klasifikasi dan SMOTE Terhadap Analisa Sentimen Mobil Listrik Indonesia
Authors: Kumalasari Jefina Tri , Puspitorini Indah 
Published: January 2025

Pesatnya perkembangaan penyimpanan energi terutama teknologi baterai membuat inovasi pada kendaraan. Perkembangan transportasi beralih dari kendaraan berbahan bakar fosil ke energi listrik dimana memiliki keuntungan ramah lingkungan dan tidak bising. Namun pada daya terima masyarakat Indonesia berbeda-beda ada yang positif dan negatif. Dinamika di masyarakat dapat di gali melalui komentar yang terdapat di Youtube. Dimana Youtube sebagai situs layanan menonton dan berbagi video yang mengalami penetrasi signifikan. Saat ini Indonesia berada di posisi ke empat sebagai pengguna Youtube sehingga situs ini sesuai digunakan sebagai sumber data. Analisa mengenai berdasarkan sentimen mengenai mobil listrik yang berasal dari salah satu kanal Youtube dimana terdapat mendapatkan hasil 65% positif dan sisanya 35% berpendapat negatif. Data diolah dengan menggunakan metode Knowledge Discovery in Data Base dengan metode CRISP-DM. Komentar awal berjumlah 1265 yang diolah dengan menggunakan metode klasifikasi pada data mining. Dengan cara membandingkan algoritma KNN, algoritma Naïve Bayes dan Algoritma SVM. Kemudian guna menyeimbangkan data dan meningkatkan akurasi peneliti mengkombinasikan dengan algoritma SMOTE. Hasil yang diperoleh integrasi algoritma SVM dan SMOTE menghasilkan keakurasian 94.65%, gabungan Naïve Bayes dan SMOTE menghasilkan akurasi 84.82% dan KNN dengan SMOTE menghasilkan 62.80%. Berdasarkan hasil perbandingan algoritma klasifikasi yang telah dilakukan didapat kombinasi algoritma SVM dan SMOTE menghasilkan prediksi terbaik.
The efficacy and safety of indobufen in patients with ischemic cardiovascular or cerebrovascular diseases: systematic review and meta-analysis
Authors: Luo Xiaolu , Lai Chenglu , Chen Tielong 
Published: January 2025

ObjectiveThis meta-analysis aims to evaluate the safety and efficacy of indobufen in the treatment of cardiovascular diseases, cerebrovascular diseases, and thromboembolic disorders. The primary focus is on the incidence of major adverse cardiovascular events (MACE), thrombosis, bleeding events, and adverse reactions. The results are intended to provide a reference for the clinical application of indobufen and suggest directions for further large-scale, multi-center, prospective studies.MethodsThis review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library databases to identify all relevant studies on indobufen. Twelve trials, all randomized controlled trials (RCTs), met the inclusion criteria. The results were presented as risk ratios (RR) with 95% confidence intervals (CI), and meta-analysis was performed using RevMan 5.3 and Stata 18.0 software.ResultsThe meta-analysis included 12 randomized controlled trials. Regarding safety, indobufen showed superior clinical outcomes compared to other antiplatelet agents regarding bleeding events, gastrointestinal adverse reactions, and overall adverse reactions, with these differences being more pronounced in cardiovascular diseases. However, the effects of both treatments on efficacy outcomes, including MACE, myocardial infarction, angina, mortality, and thrombotic events, were similar. For stroke events, particularly in patients with cerebrovascular diseases, the use of indobufen was associated with some risk.ConclusionIndobufen is associated with a lower risk of adverse reactions and bleeding, making it a viable option for patients at risk of bleeding or adverse effects, particularly in those with cardiovascular diseases. However, compared to anticoagulants such as aspirin and clopidogrel, indobufen has a shorter history of use, and its evidence base is relatively limited, highlighting the need for further research. Currently, indobufen is widely used in secondary cardiovascular and cerebrovascular prevention and provides some guidance for antiplatelet therapy in patients with gastrointestinal discomfort or bleeding risk. However, due to the potential risks in MACE, stroke, and other events, further clinical trials are needed to assess the clinical applicability of indobufen.Systematic Review Registrationhttps://www.crd.york.ac.uk/, identifier (CRD42024587938).
Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways
Authors: Taitz Jemma J. , Tan Jian , Ni Duan , Potier-Villette Camille , Grau Georges , Nanan Ralph , Macia Laurence 
Published: January 2025

IntroductionThe gut microbiota plays a pivotal role in influencing host health, through the production of metabolites and other key signalling molecules. While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.MethodsFemale C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control). Caecal microbiota composition was assessed via 16S rRNA sequencing and caecal metabolites were quantified with NMR spectroscopy. Immune profiles of spleen and mesenteric lymph nodes (MLNs) were assessed by flow cytometry, and splenocytes assessed for ex vivo cytokine production. A generalised additive model approach was used to examine the relationship between global antibiotic consumption and IBD incidence.ResultsAntibiotics significantly altered gut microbiota composition, reducing alpha-diversity. Acetate and butyrate were significantly reduced in antibiotic groups, while propionate and succinate increased in Vancomycin and PmB-treated mice, respectively. The MLNs and spleen showed changes only to DC numbers. Splenocytes from antibiotic-treated mice stimulated ex vivo exhibited increased production of TNF. Epidemiological analysis revealed a positive correlation between global antibiotic consumption and IBD incidence.DiscussionOur findings demonstrate that antibiotic-mediated dysbiosis results in significantly altered short-chain fatty acid levels but immune homeostasis in spleen and MLNs at steady state is mostly preserved. Non-specific activation of splenocytes ex vivo, however, revealed mice with perturbed microbiota had significantly elevated production of TNF. Thus, this highlights antibiotic-mediated disruption of the gut microbiota may program the host towards dysregulated immune responses, predisposing to the development of TNF-associated autoimmune or chronic inflammatory disease.
Blood leukocyte-based clusters in patients with traumatic brain injury
Authors: Wang Ruoran , Xu Jianguo , He Min 
Published: January 2025

BackgroundLeukocytes play an important role in inflammatory response after a traumatic brain injury (TBI). We designed this study to identify TBI phenotypes by clustering blood levels of various leukocytes.MethodsTBI patients from the Medical Information Mart for Intensive Care-III (MIMIC-III) database were included. Blood levels of neutrophils, lymphocytes, monocytes, basophils, and eosinophils were collected by analyzing the first blood sample within 24 h since admission. Overall, TBI patients were divided into clusters following the K-means clustering method using blood levels of five types of leukocytes. The correlation between identified clusters and mortality was tested by univariate and multivariate logistic regression analyses. The Kaplan–Meier method was used to verify the survival difference between identified TBI clusters.ResultsA total of 172 (cluster 1), 791 (cluster 2), and 636 (cluster 3) TBI patients were divided into three clusters with the following percentages, 10.8%, 49.5%, and 39.8%, respectively. Cluster 1 had the lowest Glasgow Coma Scale (GCS) and the highest Injury Severity Score (ISS) while cluster 2 had the highest GCS and the lowest ISS. The mortality rates of the three clusters were 25.6%, 13.3%, and 18.1%, respectively. The multivariate logistic regression indicated that cluster 1 had a higher mortality risk (OR = 2.211, p = 0.003) than cluster 2, while cluster 3 did not show a significantly higher mortality risk than cluster 2 (OR = 1.285, p = 0.163). Kapan–Meier analysis showed that cluster 1 had shorter survival than cluster 2 and cluster 3.ConclusionThree TBI phenotypes with different inflammatory statuses and mortality rates were identified based on blood levels of leukocytes. This classification is helpful for physicians to evaluate the prognosis of TBI patients.
Characteristics, source analysis, and risk assessment of organochlorine pesticide contamination in nearshore surface sediments of a tropical tourist island
Authors: Wang Hongbing , Zhang Lin , Yang Feng , Yan Li , Lin Cong , Shen Cheng 
Published: January 2025

Surface sediment samples were collected from the surrounding waters of the two largest tourist islands in Sanya, China, to compare and evaluate the sources, distribution, and ecological risks of 21 organochlorine pesticides (OCPs). The total concentration of OCPs ranged from 1.35 to 5.0 ng/g. Among the OCPs, ΣDDTs accounted for the largest proportion, followed by ΣHCHs. The concentrations of HCHs and DDTs from the west side of West Island were significantly higher than those from the east side, and fine-grained sediments exhibited a stronger adsorption effect on OCPs. Source analysis indicated that the area experienced new inputs of HCH pollutants, while historical residues of HCHs remained high. Residual OCPs are still widely present in the environment, transported mainly by river runoff, with a smaller portion originating from atmospheric deposition and ship paints. Ecological risk assessment results showed that factors occasionally causing adverse biological effects include Heptachlor epoxide, 4,4'-DDE, ΣDDT, Dieldrin, Endrin, and γ-HCH, while other factors rarely caused negative biological effects. Potential ecological effect evaluations indicated that stations SY03, SY04, SY06, and SY09 were classified as having moderate ecological effect levels, while other stations were classified as having no ecological effects. Strengthened investigation, monitoring, and control of pollutant sources in ecologically impacted areas are necessary. This study fills a data gap for the region and provides an academic foundation for environmental protection and the sustainable development of tourism resources.
Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia
Authors: Wang Yaping , Liu Mingyan , Liu Yaping , Tang Xiaowei , Tang Xiangming 
Published: January 2025

BackgroundAutonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patients with vascular dementia and Alzheimer’s disease compared with normal health individuals. For this purpose, we measured and analyzed the predictive value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs), heart rate acceleration capacity (AC) along with the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2).MethodsWe compared 83 dementia cases including 41 vascular dementia (VD), 42 Alzheimer’s disease (AD) patients with 42 elderly health controls. The Mini-Mental State Examination (MMSE) scores, DC, DRs, AC, and Lp-PLA2 levels were comprehensively evaluated.ResultsOur studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher. Furthermore, the risk stratification (high- and moderate-) of DC, DRs, and AC in VD and AD groups was increased, while the low-risk was simultaneously decreased. In addition, DC and DRs were positively while AC and Lp-PLA2 were negatively correlated with MMSE scores. Logistic regression analysis indicated that DC, DRs, AC, and Lp-PLA2 were associated with dementia. Moreover, the areas under the ROC curves showed that the combination of five variables and AC + Lp-PLA2 were 0.970 (95% CI, 0.923–0.992) and 0.940 (95% CI, 0.882–0.974) were larger than each single indicator alone.ConclusionDistinctive alterations in dynamic electrocardiogram-related indicators reveal a decline in autonomic nervous functions among individuals with dementia. By incorporating comprehensive analyses of DC, DRs, AC, and Lp-PLA2 values, the specificity and sensitivity of dementia diagnosis can be significantly enhanced.
Effects of salt stress on plant and rhizosphere bacterial communities, interaction patterns, and functions
Authors: Fu Maoxing , Liu Liying , Fu Bingzhe , Hou Meiling , Xiao Yanzi , Liu Yinghao , Sa Duowen , Lu Qiang 
Published: January 2025

IntroductionSalt stress significantly affects plant growth, and Na+ has gained attention for its potential to enhance plant adaptability to saline conditions. However, the interactions between Na+, plants, and rhizosphere bacterial communities remain unclear, hindering a deeper understanding of how Na+ contributes to plant resilience under salt stress.MethodsThis study aimed to investigate the mechanisms through which Na+ promotes alfalfa's adaptation to salt stress by modifying rhizosphere bacterial communities. We examined the metabolic activity and community composition of both plant and rhizosphere bacteria under Na+ treatment.Results and discussionOur results revealed significant changes in the metabolism and community composition of both plant and rhizosphere bacteria following Na+ addition. Na+ not only promoted the growth of rhizosphere bacteria but also induced shifts in the plant-associated bacterial community, increasing the abundance of bacterial species linked to alfalfa's resistance to salt stress. Furthermore, the chemical characteristics of alfalfa were strongly correlated with the composition and network complexity of both plant and rhizosphere bacterial communities. These interactions suggest that Na+ plays a crucial role in enhancing alfalfa’s adaptability to salt stress by fostering beneficial bacterial communities in the rhizosphere. This finding highlights the potential of leveraging Na+ interactions with plant-microbe systems to improve crop resilience and productivity in saline agricultural environments.