bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and investigation on synergetic effect of activated carbon loaded silver nanoparticles with enhanced photocatalytic and antibacterial activity
Authors: Ragupathy S. , Ramasundaram Subramaniyan , Krishnakumar M. , Babu A. C. Ramesh , Govindarasu Mydhili , Ramu A. G. , Oh Tae Hwan , Choi Dongjin 
Published: January 2023

Abstract
In this study, we used a cashew nut shell to successfully manufacture silver nanoparticle-loaded cashew nut shell activated carbon (Ag/CNSAC). XRD, XPS, SEM with EDS, FT-IR, and BET analysis are used to characterize the products' structural and chemical contents. The XRD, XPS, and EDS data provided convincing proof that Ag loaded on CNSAC formed. The energy dispersive spectrum analysis and X-ray diffraction pattern both supported the face-centered cubic and amorphous structures of Ag/CNSAC. The SEM micrographs showed inner surface development of Ag NPs and many tiny pores in CNSAC. The photodegradation of methylene blue (MB) dye by the Ag/CNSAC photocatalyst was investigated. This effective degradation of MB dye by Ag/CNSAC is attributed to the cooperative action of Ag as a photocatalyst and CNSAC as a catalytic support and adsorbent. In tests with gram-positive and negative bacteria including Escherichia coli (E. coli) and Staphylococcus (S. aureus), the as-product Ag/CNSAC showed outstanding antibacterial efficacy. Additionally, this study demonstrates a workable procedure for creating an affordable and efficient Ag/CNSAC for the photocatalytic eradication of organic contaminants.
Modeling the mid-Piacenzian warm climate using the water isotope-enabled Community Earth System Model (iCESM1.2)
Authors: Sun Yong , Ding Lin , Su Baohuang , Dowsett Harry , Wu Haibin , Ramstein Gilles 
Published: January 2023

Abstract

The mid-Piacenzian warm period (MPWP, ~3.264–3.025 Ma, previously referred to as the mid-Pliocene warm period), is the most recent geological period with atmospheric CO2concentrations (400ppmv) close to today, but global surface temperatures were higher than today and in equilibrium with the CO2 concentrations. Therefore, the mid-Piacenzian equilibrated climate is often compared to the modern transient climate. In this study, we conduct a water isotope-enabled Community Earth System Model (iCESM1.2) simulation to study the large-scale features of the MPWP following the protocols of Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). This MPWP simulation exhibits considerable warming in the high latitudes comparable to high-latitude MPWP surface warming evidenced in proxy records (i.e., polar amplification) that has been often underestimated in previous simulations. The improved performance of iCESM1.2over the PlioMIP2 models is due to a larger contribution of iCESM1.2-simulated downward clear-sky surface long wave radiation fluxes affecting polar amplification. Compared to the PI period, the total precipitation simulated by iCESM1.2 is generally wetter than the PlioMIP2 multi-model ensemble mean (MME) except for the opposite performance between iCESM1.2 and PlioMIP2 MME over the regions [~30S°–10N]. A heavier δ18Op during the MPWP mainly occurred in the tropical Indian ocean and surrounding Asian-African-Australian monsoon regions. There are contrasting changes in the tropical meridional and zonal atmospheric circulations (Hadley and Walker cells) during the MPWP. A weakened and expanded Hadley circulation (toward the poles) led to a reduction in tropical precipitation [~30S°–10N] and a poleward shift of the edge of the northern subtropical arid zone. In contrast, the tropical zonal atmospheric overturning circulation (Walker cell) and the global ocean meridional overturning circulation (MOC) are generally enhanced during the MPWP compared to the PI period.
DHX9 strengthens atherosclerosis progression by promoting inflammation in macrophages
Authors: Huangfu Ning , Ma Hongchuang , Tian Mengyun , Zhang Jie , Wang Yong , Li Zhenwei , Chen Xiaomin , Cui Hanbin 
Published: January 2023

Abstract
Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages play important roles in atherosclerosis. DExH-Box helicase 9 (DHX9), as a member of DExD/H-box RNA helicase superfamily II, is identified as an autoantigen in the sera of systemic lupus erythematosus patients to trigger inflammation. The aim of this study was to investigate whether DHX9 is involved in AS development, especially in macrophages-mediated-inflammatory responses. We find that DHX9 expression is significantly increased in oxLDL or interferon-γ-treated macrophages and peripheral blood mononuclear cells (PBMCs) from patients with coronary artery disease (CAD). Knockdown of DHX9 inhibits lipid uptake and pro-inflammatory factors expression in macrophages, and ameliorates TNF-α-mediated monocyte adhesion capacity. Furthermore, we find that oxLDL stimulation promotes DHX9 interacting with p65 in macrophages, and further enhances the transcriptional activity of DHX9-p65-RNA Polymerase II complex to produce inflammatory factors. Moreover, using ApoE -/- mice fed with western diet to establish AS model, we find that knockdown of DHX9 medicated by adeno-associated virus-Sh-DHX9 through tail vein injection evidently alleviates AS progression in vivo. Finally, we also find that knockdown of DHX9 inhibits p65 activation, inflammatory factors expression, and the transcriptional activity of p65-RNA Polymerase II complex in PBMCs from patients with CAD. Overall, these results indicate that DHX9 promotes AS progression by enhancing inflammation in macrophages, and suggest DHX9 as a potential target for developing therapeutic drug.
A Lightweight Cross-Layer Intrusion Detection System on Jamming, Spoofing, and Mixed Attacks in Vehicular Communication
Authors: Fathi Mohammad , Sobhani Seyed naeim 
Published: January 2023

Abstract
A vehicular ad-hoc network (VANET) is among the communication networks classified as a subset of the Internet of things (IoT). In fact, it is considered as an effective solution to smartification of transportation systems and prevention of traffic collisions. The pervasiveness and wireless nature of communications in a VANET can provide a good opportunity for the presence of intruders and malicious users. However, the slightest disruption in the performance of this network can jeopardize people’s lives. This study aims to propose an intrusion detection system based on the cross-layer approach through supervised machine learning techniques to confront jamming and spoofing attacks in VANETs. For this purpose, 31 detection systems are developed and analyzed by combining five features (i.e., SINR, RSSI, speed, distance, and network congestion) and decision systems including decision tree, SVM, and K-NN algorithms. The proposed detection system can correctly classify and detect test data through the decision tree, SVM, and K-NN algorithms with approximate accuracies of 98%, 97%, and 96.67%, respectively. Moreover, considering the detection time, decision tree is selected as the fastest detection algorithm. Finally, this study proposes a lightweight intrusion detection system with an approximate accuracy of 98% by integrating three features of speed, distance and network congestion to detect jamming and spoofing attacks in a VANET.
Hybrid model outperformed individual models in predicting droughts in a semi-arid region of Bangladesh
Authors: Mahmud Shahed , Shahriar Shihab A. , Hossain Md. Lokman , Islam Rashik , Das Ashim C. , Salam Mohammed Abdus 
Published: January 2023

Abstract
Drought is one of the most significant repercussions of climate change. Worldwide droughts affect food security and ecological productivity. Bangladesh has faced a series of droughts over the past few decades, with significant economic and environmental consequences. The north-western region of Bangladesh is the most affected by drought because of its geographical location and semi-arid climate. With the increasing frequency and severity of droughts, rapid and reliable drought information is essential for agro-ecological production and food security. Using the Standardized Precipitation Index (SPI) and three models (Auto Regressive Moving Average (ARMA), PROPHET, and ARMA-Generalized Autoregressive Conditional Heteroskedasticity (ARMA-GARCH)), we assessed the trends of drought in the five meteorological stations (Bogra, Dinajpur, Ishwardi, Rajshahi, and Rangpur) in the north-western region of Bangladesh for the period 1980–2019. Results show that the SPI trends were significant for Dinajpur and Ishwardi stations but insignificant for the other three stations (Bogra, Rajshahi, and Rangpur). Among the three models, the hybrid model (ARMA-GARCH) outperformed the individual models (ARMA and PROPHET), which suggests that the ARMA-GARCH model could be utilized to predict droughts as it showed higher accuracy than that of individual models. This study provides empirical evidence of (i) the intensification of drier climates in the north-western region of Bangladesh over the 40 years, which has practical implications for introducing climate adaptive practices in agriculture and other livelihood sectors, and (ii) the better performance of a hybrid model compared to individual models in predicting drought, which is of great significance for government decision-making.
Açaí palm intensification and the reorganization of woody plant assemblages at multiple spatial scales in an Amazonian estuarine forest
Authors: Barros¹ Maria Fabíola , Jardim Mário Augusto Gonçalves , Soares³ Victor Fernando Silva , Menezes Paula Maria Melo , Vieira Ima Célia Guimarães , Tabarelli Marcelo 
Published: January 2023

Abstract
The exploitation of non-timber forest products has been proposed as a sustainable way to exploit tropical forests, but such an opportunity remains to examined case-by-case. We examine the impact by the intensification of the açaí palm (Euterpe oleracea) management for fruit production via increments on palm clumps/stems density on the woody plant assemblages (adult and regenerating) in an estuarine forest landscape in the eastern Amazon region, Brazil. Across 30 forest stands açaí clumps density correlated negatively with stem density and taxonomic diversity considering both adult and regenerating woody plant assemblages, but it posed a positive effect on beta diversity via species turnover. Soil fertility and forest stand accessibility played a complementary role. Moreover, açaí clump density affected the abundance of particular woody plant species, including a set of species declining before the 400-açaí clump density threshold imposed by current regulation. Accordingly, açaí clump density influenced the taxonomic organization of woody plant assemblages at landscape spatial level. Finally, it is worth mention a group of 105 species, which were recorded across the regenerating assemblages but not in the adult assemblages. Among them, a large number of small-statured woody plant species typical from the forest understory (i.e., the shade-tolerant flora) such as those from Miconia, Piper, Bactris, Anonna and Geonoma genus among many. As intensification is still spreading it can be considered a threat to the integrity of the Amazon estuarine forest. It questions the ecological sustainability the current Amazonian “black gold” is produced.
A class of optimal frequency hopping sequences based on the decimated m-sequences
Authors: Qin Qingru , Su Wei , Wang Jianpeng 
Published: January 2023

Abstract
In frequency hopping communication system, the correlation characteristic of frequency hopping sequence is an important standard to measure the system performance. Therefore, the design of new frequency hopping sequences with low correlation property has always been one of the important topics in frequency hopping systems. In this paper, we present a class of frequency hopping sequences with respect to the Lempel-Greenberger bound, which is based on the character sums over finite fields and the decimation of m-sequences. The parameters of this frequency hopping sequences are new.
Mathematics Subject Classification: 11B50, 11B65, 11B83.
High expression of PPIA associates with poor prognosis and tumor immune infiltration of gastric cancer
Authors: Liu Jichao , Wang Yanjun , Zhao Zhiwei , Ge Yanhui 
Published: January 2023

AbstractBackground Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the lack of effective diagnostic indicators, most patients are diagnosed in late stage and have a poor prognosis. An increasing number of studies have proved that PPIA can play an oncogene role in various cancer types. However, the precise mechanism of PPIA in GC is still unclear. Methods The mRNA levels of PPIA in pan-cancer and the prognostic value of PPIA on GC was evaluated using multiple databases. Additionally, the relationship between PPIA expression and clinical factors in GC was also examined. Moreover, the genetic alteration and DNA methylation analysis was conducted. Furthermore, the upstream regulator miRNA and lncRNA of PPIA were identified. Finally, the relationship between PPIA expression and immune checkpoint expression, immune cell biomarkers, and immune cell infiltration in GC were also performed by TIMER database. Results PPIA was upregulated in most tumor tissues compared to the corresponding normal tissues including GC and PPIA expression had a close relationship with GC patients. However, the abnormal expression of PPIA was not affected by genetic alteration and DNA methylation. We confirmed that PPIA was regulated by upstream ncRNAs and the upstream regulator miRNA and lncRNA of PPIA were identified. Finally, this study revealed that PPIA was negatively correlated with immune checkpoint expression, immune cell biomarkers, and immune cell infiltration in GC. Conclusions lnc01232/miRNA-204-5p/PPIA axis might act as a potential biological pathway in GC and negatively related to immune cell infiltration in GC.
Test Case Reduction and SWOA Optimization for Distributed Agile Software Development Using Regression Testing
Authors: Singh Madan , Chauhan Naresh , Popli Rashmi 
Published: January 2023

Abstract

Regression testing is a well-established practice in software development, but its position and importance have shifted in recent years as agile approaches have grown in popularity, emphasizing the fundamental role of regression testing in preserving software quality. In previous techniques, the challenge to address is determining the number and size of clusters and optimization to stability the cost and efficacy of the strategy. To overcome all the existing drawbacks; this research study proposes Test Case Reduction and SWOA Optimization for Distributed Agile Software Development Using Regression Testing. The purpose of this research study is to look into regression testing strategies in agile development teams and to find out what they are optimum clustered test cases. The proposed strategy is divided into two stages that are prioritization as well as selection. Prioritization and selection are carried out once the test instances have been retrieved and grouped. The test clusters are sorted and prioritized in this stage to ensure that the most critical instances are chosen first. Second, the Support-based Whale Optimization Algorithm (SWOA) is used to choose test cases with a greater frequency of failure or coverage criterion. The results of the assessment metrics show that the proposed approach outperforms other current regression testing strategies substantially. Our suggested technique outperforms current methods in terms of information, according to the findings of the trials.
Association between Antibiotic Use and Subsequent Risk of Prostate Cancer: A Retrospective Cohort Study in South Korea
Authors: Park Sun Jae , Hong Jaeyi , Park Young Jun , Jeong Seogsong , Choi Seulggie , Chang Jooyoung , Oh Yun Hwan , Han Minjung , Ko Ahryoung , Kim Sugyeong , Cho Yoosun , Kim Ji Soo , Son Joung Sik , Park Sang Min 
Published: January 2023

Abstract
Background
Several studies suggest that antibiotic use may affect overall cancer incidence, but the association between antibiotics and prostate cancer is still unclear.
Methods
A population-based retrospective cohort study was conducted using the Korean National Health Insurance Service (NHIS) database. 1,032,397 individuals were followed up from January 1, 2007, to December 31, 2019. Multivariate Cox hazards regression was utilized to calculate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the risk of prostate cancer according to accumulative days of antibiotic use and the number of antibiotic classes used.
Results
Individuals who used antibiotics for 180 or more days had a higher risk of prostate cancer (aHR, 1.46; 95% CI, 1.11-1.91) than those who did not use antibiotics. Also, individuals who used four or more kinds of antibiotics had a higher risk of prostate cancer (aHR, 1.18; 95% CI, 1.07-1.30) than antibiotic non-users. A similar trend was observed among participants who underwent health examinations.
Conclusion
Our findings suggest that long-term use of antibiotics may affect prostate cancer incidence. Further studies are needed to improve understanding of the association between antibiotic use and prostate cancer incidence.
Correlation between the Thyroid Image and Reporting Data System (TIRADS) and the Bethesda System for Reporting the Thyroid Cytopathology in Patients with Thyroid Nodules
Authors: Ghazi Faiz Najmuddin , Zain Wan Zainira Wan , Yahya Maya Mazuwin , Haron Juhara , Rahman Wan Faiziah Wan Abdul , Zakaria Zaidi , Mokhter Wan Mokhzani Wan , Mamat Ahmad Zuhdi , Has Mohd Nizam Md , Ramely Rosnelifaizur , Wong Michael Pak-Kai 
Published: January 2023

Abstract

Background: The thyroid imaging and reporting data system (TIRADS) has been routinely used to report thyroid nodules since its introduction in 2017. Similarly, the Bethesda system is a well-validated method used to report the cytopathology of thyroid lesions for over a decade. The aim of this study was to investigate the correlations between these two systems.
Methods: This retrospective cohort study comprised patients who underwent ultrasound assessments of the thyroid gland followed by fine needle aspiration cytology (FNAC) of the thyroid nodules at a teaching hospital. The variables were categorised into ultrasound and cytological findings, and the outcomes measured from the two systems (validity of the system and risk of malignancy in each group of thyroid nodules) were correlated. Spearman’s correlation was used to determine the correlation, and the Kappa test was used to determine the agreement between the systems.
Results: A total of 295 patients who fulfilled the inclusion criteria were identified during the study period. Females represented 82.7% of the study population, and the majority of the patients presented with multiple thyroid nodules (74.2%) and bilateral diseases (60.7%). The number of patients with TIRADS 3 and 4 nodules was 102 and 132, respectively, whereas the highest number of patients (n = 231) presented with the Bethesda II subcategory. Only 31.5% of the patients underwent thyroidectomy, and 18.3% had a final histological diagnosis of thyroid malignancy. The Spearman’s correlation value (ρ) between TIRADS and Bethesda was 0.464 (p < 0.001), and the linear-weighted kappa was 0.203 (95% confidence interval [CI], 0.153–0.253), indicating a good correlation between the two systems. Both systems showed good diagnostic accuracy (area under the curve [AUC], 85.8% and 85.6%, respectively). The malignancy risks for TIRADS 2, 3, 4 and 5 were 0%, 2.9%, 18.2% and 93.1%, respectively.
Conclusions: Good correlations were observed between the TIRADS and Bethesda systems. Thus, they can be used to predict the cytological results of FNAC, which will aid in achieving more accurate decisions for both biopsy and surgical interventions while managing the thyroid nodule.
Maternal diet enriched with African walnuts confers neurodevelopmental resilience to MnCl2-induced neurotoxic cascades in rats
Authors: Arogundade Tolulope Timothy , Gbadamosi Ismail , Atoyebi Aminat , Bamisi Olawande , Lewu Folasade Susan , Tokunbo Olorunfemi , Yawson Emmanuel , Lambe Ezra , Arogundade Olutayo , Olajide Olayemi Joseph , Enaibe Bernard 
Published: January 2023

Abstract

Background: Early experiences at critical milestones significantly impact neurocognitive outcomes by altering brain development. Such issues can affect children’s academic achievement, disturb their behaviour, lower their quality of life, and raise their risk of derangement in adulthood. These problems are linked to many possible neurotoxicants, including high ambient manganese (Mn) exposure. Walnuts possess high levels of ω-3 fatty acids and a high content of potent phytochemicals, all of which play an essential role in brain health. This present study explored the ability of a maternal walnut-enriched diet (WED) to protect against MnCl2-induced developmental neurotoxicity in utero vis-à-vis early postnatal stages in rats. Dams were exposed to diet and Mn treatment during gestation and/or preweaning periods. At the onset of adolescence (~postnatal day 28), offspring of dams were examined on the Y-maze and elevated-plus maze to evaluate working memory and anxiety levels. After euthanasia, cortical and hippocampal tissues were harvested for subsequent analyses by histology, histochemistry, PCR, and spectrophotometry methods. All data were analyzed using One-way ANOVA followed by Tukey’s test for multiple comparisons. Significance was set at p<0.05.
Results: Offspring of dams treated with MnCl2 exhibited a significant reduction in working memory and a loss of emotional stability, which was restored by WED; Mn aberrations in histomorphology of the PFC and hippocampus were abated by WED; dysregulation in gene expression of DNMT3A, H2Ax, BDNF, and OPA1 was prevented by developmental WED; upregulated levels of pro-inflammatory cytokines which correlated with MnCl2 exposure was significantly reduced by walnut supplementation and; finally, accompanied perturbation of the cholinergic system (AChE) by MnCl2 was significantly counteracted by WED.
Conclusion: Our data suggest that WED intervened and forestalled deficits in behaviour, structural alterations, and functional dysregulation arising from manganese neurotoxicity in developing rats.