bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Holistic Solution to Icing by Acoustic Waves: De‐Icing, Active Anti‐Icing, Sensing with Piezoelectric Crystals, and Synergy with Thin Film Passive Anti‐Icing Solutions
Authors: del Moral Jaime , Montes Laura , Rico‐Gavira Victor Joaquin , López‐Santos Carmen , Jacob Stefan , Oliva‐Ramirez Manuel , Gil‐Rostra Jorge , Fakhfouri Armaghan , Pandey Shilpi , Gonzalez del Val Miguel , Mora Julio , García‐Gallego Paloma , Ibáñez‐Ibáñez Pablo Francisco , Rodríguez‐Valverde Miguel Angel , Winkler Andreas , Borrás Ana , González‐Elipe Agustin Rodriguez 
Published: February 2023

AbstractIcing has become a hot topic both in academia and in the industry given its implications in transport, wind turbines, photovoltaics, and telecommunications. Recently proposed de‐icing solutions involving the propagation of acoustic waves (AWs) at suitable substrates may open the path for a sustainable alternative to standard de‐icing or anti‐icing procedures. Herein, the fundamental interactions are unraveled that contribute to the de‐icing and/or hinder the icing on AW‐activated substrates. The response toward icing of a reliable model system consisting of a piezoelectric plate activated by extended electrodes is characterized at a laboratory scale and in an icing wind tunnel under realistic conditions. Experiments show that surface modification with anti‐icing functionalities provides a synergistic response when activated with AWs. A thoughtful analysis of the resonance frequency dependence on experimental variables such as temperature, ice formation, or wind velocity demonstrates the application of AW devices for real‐time monitoring of icing processes.
Highly Tunable Syngas Product Ratios Enabled by Novel Nanoscale Hybrid Electrolytes Designed for Combined CO2 Capture and Electrochemical Conversion
Authors: Feric Tony G. , Hamilton Sara T. , Ko Byung Hee , Lee Gahyun Annie , Verma Sumit , Jiao Feng , Park Ah‐Hyung Alissa 
Published: February 2023

AbstractCoupling renewable energy with the electrochemical conversion of CO2 to chemicals and fuels has been proposed as a strategy to achieve a new circular carbon economy and help mitigate the effects of anthropogenic CO2 emissions. Liquid‐like Nanoparticle Organic Hybrid Materials (NOHMs) are composed of polymers tethered to nanoparticles and are previously explored as CO2 capture materials and electrolyte additives. In this study, two types of aqueous NOHM‐based electrolytes are prepared to explore the effect of CO2 binding energy (i.e., chemisorption versus physisorption) on CO2 electroreduction over a silver nanoparticle catalyst for syngas production. Poly(ethylenimine) (PEI) and Jeffamine M2070 (HPE) are ionically tethered to SiO2 nanoparticles to form the amine‐containing NOHM‐I‐PEI and ether‐containing NOHM‐I‐HPE, respectively. At less negative cathode potentials, PEI and NOHM‐I‐PEI‐based electrolytes produce CO at higher rates than 0.1 molal. KHCO3 due to favorable catalyst‐electrolyte interactions. Whereas at more negative potentials, H2 production is favored because of the carbamate electrochemical inactivity. Conversely, HPE and NOHM‐I‐HPE‐based electrolytes display poor CO2 reduction performance at less negative potentials. At more negative potentials, their performance approached that of 0.1 molal. KHCO3, highlighting how the polymer functional groups of NOHMs can be strategically selected to produce value‐added products from CO2 with highly tunable compositions.
Effect of Phosphorus Modulation in Iron Single‐Atom Catalysts for Peroxidase Mimicking
Authors: Ding Shichao , Barr Jordan Alysia , Lyu Zhaoyuan , Zhang Fangyu , Wang Maoyu , Tieu Peter , Li Xin , Engelhard Mark H. , Feng Zhenxing , Beckman Scott P. , Pan Xiaoqing , Li Jin‐Cheng , Du Dan , Lin Yuehe 
Published: February 2023

AbstractFe–N–C single‐atom catalysts (SACs) exhibit excellent peroxidase (POD)‐like catalytic activity, owing to their well‐defined isolated iron active sites on the carbon substrate, which effectively mimic the structure of natural peroxidase's active center. To further meet the requirements of diverse biosensing applications, SAC POD‐like activity still needs to be continuously enhanced. Herein, a phosphorus (P) heteroatom is introduced to boost the POD‐like activity of Fe–N–C SACs. A 1D carbon nanowire (FeNCP/NW) catalyst with enriched Fe–N4 active sites is designed and synthesized, and P atoms are doped in the carbon matrix to affect the Fe center through long‐range interaction. The experimental results show that the P‐doping process can boost the POD‐like activity more than the non‐P‐doped one, with excellent selectivity and stability. The mechanism analysis results show that the introduction of P into SAC can greatly enhance POD‐like activity initially, but its effect becomes insignificant with increasing amount of P. As a proof of concept, FeNCP/NW is employed in an enzyme cascade platform for highly sensitive colorimetric detection of the neurotransmitter acetylcholine.
Energy Efficient Neuro‐Inspired Phase–Change Memory Based on Ge4Sb6Te7 as a Novel Epitaxial Nanocomposite
Authors: Khan Asir Intisar , Yu Heshan , Zhang Huairuo , Goggin John R. , Kwon Heungdong , Wu Xiangjin , Perez Christopher , Neilson Kathryn M. , Asheghi Mehdi , Goodson Kenneth E , Vora Patrick M. , Davydov Albert , Takeuchi Ichiro , Pop Eric 
Published: February 2023

AbstractPhase‐change memory (PCM) is a promising candidate for neuro‐inspired, data‐intensive artificial intelligence applications, which relies on the physical attributes of PCM materials including gradual change of resistance states and multilevel operation with low resistance drift. However, achieving these attributes simultaneously remains a fundamental challenge for PCM materials such as Ge2Sb2Te5, the most commonly used material. Here bi‐directional gradual resistance changes with ≈10× resistance window using low energy pulses are demonstrated in nanoscale PCM devices based on Ge4Sb6Te7, a new phase‐change nanocomposite material . These devices show 13 resistance levels with low resistance drift for the first 8 levels, a resistance on/off ratio of ≈1000, and low variability. These attributes are enabled by the unique microstructural and electro‐thermal properties of Ge4Sb6Te7, a nanocomposite consisting of epitaxial SbTe nanoclusters within the Ge–Sb–Te matrix, and a higher crystallization but lower melting temperature than Ge2Sb2Te5. These results advance the pathway toward energy‐efficient analog computing using PCM.
Flexible Hybrid Piezoelectric‐Electrostatic Device for Energy Harvesting and Sensing Applications
Authors: Lu Zhaocheng , Zhang Chi , Kwon Sun Hwa , Jiang Zhipeng , Dong Lin 
Published: February 2023

AbstractConverting mechanical energy from either the ambient environment or the human body motions to the useful electrical energy will revolutionize power solutions for flexible electronics. Here, a hybrid energy harvesting strategy is reported, which combines porous polymeric piezoelectric film with an electrostatic layer as an integration for converting the mechanical energy into electrical energy. The piezoelectric materials through engineered microstructures are developed to enhance energy generation due to the higher compressibility and larger surface contact area. The electrostatic effect from the charged layer further contributes to the generation of electrical charges. By directly coating the stretchable carbon nanotubes onto the elastomers, more intimate integration of the hybrid energy harvesters enables the designs for complex electronics. Such flexible hybrid piezoelectric‐electrostatic device exhibits superior energy harvesting performance with a voltage output of 1.95 V, which improves 30% and 100% compared to the electrostatic and piezoelectric alone device, respectively. Experiments are also performed to demonstrate the implementation of the hybrid device's energy conversion to power small electronics and recognition of different body motions. Such hybrid strategy provides a new solution toward future energy revolution for flexible electronics.
Novel Self‐Assembled Multifunctional Nanoprobes for Second‐Near‐Infrared‐Fluorescence‐Image‐Guided Breast Cancer Surgery and Enhanced Radiotherapy Efficacy
Authors: Zhang Yong‐Qu , Liu Wan‐Ling , Luo Xiang‐Jie , Shi Jun‐Peng , Zeng Yun‐Zhu , Chen Wei‐Ling , Huang Wen‐He , Zhu Yuan‐Yuan , Gao Wen‐Liang , Li Rong‐Hui , Ming Zi‐He , Zhang Li‐Xin , Yang Rui‐Qin , Wang Jia‐Zheng , Zhang Guo‐Jun 
Published: February 2023

AbstractBreast‐conserving surgery (BCS) is the predominant treatment approach for initial breast cancer. However, due to a lack of effective methods evaluating BCS margins, local recurrence caused by positive margins remains an issue. Accordingly, radiation therapy (RT) is a common modality in patients with advanced breast cancer. However, while RT also protects normal tissue and enhances tumor bed doses to improve therapeutic effects, current radiosensitizers cannot meet these urgent clinical needs. To address this, a novel self‐assembled multifunctional nanoprobe (NP) gadolinium (Gd)–diethylenetriaminepentaacetic acid–human serum albumin (HSA)@indocyanine green–Bevacizumab (NPs‐Bev) is synthesized to improve the efficacy of fluorescence‐image‐guided BCS and RT. Fluorescence image guidance of the second near infrared NP improves complete resection in tumor‐bearing mice and accurately discriminates between benign and malignant mammary tissue in transgenic mice. Moreover, targeting tumors with NPs induces more reactive oxygen species under X‐ray radiation therapy, which not only increases RT sensitivity, but also reduces tumor progression in mice. Interestingly, self‐assembled NPs‐Bev using HSA, the magnetic resonance contrast agent and Bevacizumab‐targeting vascular growth factor A, which are clinically safe reagents, are safe in vitro and in vivo. Therefore, the novel self‐assembled NPs provide a solid precision therapy platform to treat breast cancer.
Field level comparison of rhizosphere microbiome characteristics between wheat cultivars Jimai22 and Xiaoyan22
Authors: Chen Xiaoyan , Xu Dongqing , Zhang Yubin , Zhang Lijun , Li Fei 
Published: February 2023

AbstractThe rhizosphere microbiome can regulate various plant biological activities; however, the composition of the rhizosphere microbiome is easily affected by the growing environment and plant genotype. To further explore the differences and the interaction mechanisms between the rhizosphere microbiome of different wheat cultivars planted in northern China, we systematically compared the rhizosphere microbiome of major wheat cultivars Jimai22 and Xiaoyan22 planted in the field in Jinan and Qingdao, Shandong Province. The rhizosphere microbiome data were obtained from Jimai22 and Xiaoyan22 at the three‐leaf stage by 16S rRNA gene amplicon sequencing and were compared based on diversity analysis, principal coordinates’ analysis, machine learning methods such as random forest, and network analysis. The results showed that the plant growing environment and genotype significantly affected the community structure of the wheat rhizosphere microbiome. Operational taxonomic units belonged to Actinobacteria, Bacteroidetes, Firmicutes, Acidobacteria, and Proteobacteria were differentially enriched between the two wheat genotypes. Moreover, random forest model could accurately (accuracy rate 96.4%) predict wheat genotype across locations based on differences in rhizosphere microbiome of Jimai22 and Xiaoyan22. The findings of this study provide supporting data and a theoretical basis for in‐depth understanding of the composition of the rhizosphere microbiome of wheat planted in northern China, which can be applied to improve wheat breeding from the perspective of root microbe–plant interaction.
A single bout of breast milk expression does not increase resting metabolic rate
Authors: Reynolds Leryn J. , Powell Kayla R. , Akhter Taskina , Twiddy Hannah M. , Wilson Patrick B. 
Published: February 2023

AbstractIntroductionBreastfeeding women have elevated resting metabolic rate (RMR); however, whether a single bout of lactation increases RMR is unknown. This study aimed to determine if a single bout of lactation acutely increased RMR.MethodsTwenty‐two lactating women (age: 31 ± 0.9 year, body mass index: 27.3 ± 1.2 kg/m2) were recruited. RMR was assessed at baseline and at 1‐ and 2‐h following breast milk expression.ResultsRMR was unchanged in lactating women following a single bout of lactation (baseline: 1437 ± 39; 1 h: 1425 ± 37 2 h: 1440 ± 31 kcal/day) (p > .05). RMR was not correlated to daily milk produced (r = 0.05, p > .05), but was correlated to body mass (r = 0.74, p < .001), fat‐free mass (kg) (r = 0.61, p < .01), and fat mass (kg) (r = 0.71, p < .01).ConclusionRMR in lactating women appears to be more related to body mass or composition in the postpartum period rather than lactation.
Efficient Synthesis of α‐P‐Modified Nucleoside Triphosphates and Dinucleoside Tetraphosphates via Linear PVPVPIII‐Nucleoside Intermediates
Authors: Dong Ying‐Ying , Huang Hua‐Shan , Zhong Ren‐Yuan , Gong Shan‐Shan , Sun Qi 
Published: February 2023

AbstractAs an important class of nucleoside triphosphate analogues, α‐P‐modified nucleoside triphosphates (NTPαXs) have long been recognized as versatile tools in molecular biology and medicinal chemistry. However, the available synthetic methods based on modified nucleoside monophosphate and cyclic PVPVPIII‐nucleoside intermediates are only low to moderate‐yielding. Inspired by recent progress on PV‐PIII coupling reactions, we attempted to access NTPαXs via the putative linear PVPVPIII‐nucleoside intermediates. The current research found that a specific type of nucleoside phosphoramidites, fluorenylmethyl (Fm) nucleosidyl‐phosphoromorpholidites, are highly reactive in coupling with nBu4NH3P2O7 even without acidic activators. In situ oxidation of linear PVPVPIII‐nucleosides with specific sulfurizing, boranylating, and selenylating reagents followed by deprotection of α‐P and nucleoside moieties afforded NTPαXs (X=S, Se, and BH3) in excellent isolated yields. By exploiting dicyanoimidazole (DCI)’s promoting effect on PV‐PIII coupling, the current linear PVPVPIII‐nucleoside‐based method was further developed into an efficient route to α‐P‐modified dinucleoside tetraphosphates.
Camouflaged Virus‐Like‐Nanocarrier with a Transformable Rough Surface for Boosting Drug Delivery
Authors: Yu Hongyue , Yu Yan , Lin Runfeng , Liu Minchao , Zhou Qiaoyu , Liu Mengli , Chen Liang , Wang Wenxing , Elzatahry Ahmed A. , Zhao Dongyuan , Li Xiaomin 
Published: February 2023

AbstractDue to non‐specific strong nano–bio interactions, it is difficult for nanocarriers with permanent rough surface to cross multiple biological barriers to realize efficient drug delivery. Herein, a camouflaged virus‐like‐nanocarrier with a transformable rough surface is reported, which is composed by an interior virus‐like mesoporous SiO2 nanoparticle with a rough surface (vSiO2) and an exterior acid‐responsive polymer. Under normal physiological pH condition, the spikes on vSiO2 are hidden by the polymer shell, and the non‐specific strong nano–bio interactions are effectively inhibited. While in the acidic tumor microenvironment, the nanocarrier sheds the polymer camouflage to re‐expose its rough surface. So, the retention ability and endocytosis efficiency of the nanocarrier are great improved. Owing to it's the dynamically variable rough surface, the rationally designed nanocarrier exhibits extended blood‐circulation‐time and enhanced tumor accumulation.
3′‐O‐(2‐Nitrobenzenesulfonyl)fluorescein as a Fluorescent Probe for Hydrogen Polysulfides by Straightforward One‐Step Deprotection
Authors: Tsukamoto Koji , Ohsawa Hikaru , Nishiyama Ryosuke , Maeda Hatsuo 
Published: February 2023

AbstractInvited for this month's cover is the group of Prof. Hatsuo Maeda at Hyogo Medical University, Japan. The cover picture features selective visualization of hydrogen polysulfides (H2Sn, n ≥ 2) over other related species through a fluorogenic reaction of 3′‐O‐(2‐nitrobenzenesulfonyl)fluorescein, that was screened as the best practical H2Sn probe among 2‐ or 4‐nitrobenzenesulfonylated fluorescein derivatives. More information can be found in the Research Article by K. Tsukamoto, H. Maeda, and co‐workers.
A Practical Method to Detect, Analyze, and Engineer Higher Order Van Hove Singularities in Multi‐band Hamiltonians
Authors: Chandrasekaran Anirudh , Betouras Joseph J. 
Published: February 2023

AbstractA practical method is presented to detect, diagnose, and engineer higher order Van Hove singularities in multiband systems, with no restrictions on the number of bands or hopping terms. The method allows us to directly compute the Taylor expansion of the dispersion of any band at arbitrary points in momentum space, using a generalized extension of the Feynman–Hellmann theorem, which is stated and proved. Being fairly, in general scope, it also allows to incorporate and analyze the effect of tuning parameters on the low energy dispersions, which can greatly aid the engineering of higher order Van Hove singularities. A certain class of degenerate bands can be handled within this framework. The use of this method is demonstrated, by applying it to the Haldane model.
Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold
Authors: Musatat Ahmad Badreddin , Atahan Alparslan , Ergün Adem , Çıkrıkcı Kübra , Gençer Nahit , Arslan Oktay , Zengin Mustafa 
Published: February 2023

AbstractThis study reports the facile synthesis of a novel series of benzothiazole‐chalcones, in addition to their inhibitory profile on important metabolic enzymes including human carbonic anhydrases (hCA‐I, hCA‐II) and paraoxonase (PON‐1). The inhibition parameters, IC50 (concentration for 50% inhibition) and Ki (dissociation constant) values, toward the title enzymes were determined for the studied compounds. As a result, IC50 values of hydratase activity were in the range 4.15–5.47 and 2.56–4.58 μM for hCA‐I and hCA‐II, respectively. At the same time, IC50 values of esterase activity were in the range 24.91–104.00 and 35.25–97.00 μM, while Ki values were in the range 14.43–59.66 and 26.65–73.34 μM for hCA‐I and hCA‐II, respectively. In addition, PON‐1 enzyme inhibition results showed interesting inhibitory effects, with IC50 values between 13.28 and 16.68 μM. Finally, a comprehensive approach was established for the synthesized compounds based on theoretical calculations, which have been done using B3LYP, PBE0 theories and SVP, TVZP, TVZPP basis sets, followed by docking studies by which the outputs proved the harmonically flows with the experimental results.
BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges
Authors: Thakkar Bhushan , Acevedo Edmund O. 
Published: February 2023

AbstractIntroductionThe primary objective of this paper is to (1) provide a summary of human studies that have used brain derived neurotrophic factor (BDNF) as a biomarker, (2) review animal studies that help to elucidate the mechanistic involvement of BDNF in the development and maintenance of neuropathic pain (NP), and (3) provide a critique of the existing measurement techniques to highlight the limitations of the methods utilized to quantify BDNF in different biofluids in the blood (i.e., serum and plasma) with the intention of presenting a case for the most reliable and valid technique. Lastly, this review also explores potential moderators that can influence the measurement of BDNF and provides recommendations to standardize its quantification to reduce the inconsistencies across studies.MethodsIn this manuscript we examined the literature on BDNF, focusing on its role as a biomarker, its mechanism of action in NP, and critically analyzed its measurement in serum and plasma to identify factors that contribute to the discrepancy in results between plasma and serum BDNF values.ResultsA large heterogenous literature was reviewed that detailed BDNF's utility as a potential biomarker in healthy volunteers, patients with chronic pain, and patients with neuropsychiatric disorders but demonstrated inconsistent findings. The literature provides insight into the mechanism of action of BDNF at different levels of the central nervous system using animal studies. We identified multiple factors that influence the measurement of BDNF in serum and plasma and based on current evidence, we recommend assessing serum BDNF levels to quantify peripheral BDNF as they are more stable and sensitive to changes than plasma BDNF.ConclusionAlthough mechanistic studies clearly explain the role of BDNF, results from human studies are inconsistent. More studies are needed to evaluate the methodological challenges in using serum BDNF as a biomarker in NP.
Implantable device with magnetically rotating disk for needle‐free administrations of emergency drug
Authors: Kim Cho Rim , Han Jae Hoon , Kim Min Ji , Kim Myoung Ju , Kim Se‐Na , Cho Yong Chan , Ji Han Bi , Min Chang Hee , Lee Cheol , Choy Young Bin 
Published: February 2023

AbstractPrompt administration of first‐aid drugs can save lives during medical emergencies such as anaphylaxis and hypoglycemia. However, this is often performed by needle self‐injection, which is not easy for patients under emergency conditions. Therefore, we propose an implantable device capable of on‐demand administration of first‐aid drugs (i.e., the implantable device with a magnetically rotating disk [iMRD]), such as epinephrine and glucagon, via a noninvasive simple application of the magnet from the outside skin (i.e., the external magnet). The iMRD contained a disk embedded with a magnet, as well as multiple drug reservoirs that were sealed with a membrane, which was designed to rotate at a precise angle only when the external magnet was applied. During this rotation, the membrane on a designated single‐drug reservoir was aligned and torn to expose the drug to the outside. When implanted in living animals, the iMRD, actuated by an external magnet, delivers epinephrine and glucagon, similar to conventional subcutaneous needle injections.
Diversity‐Driven Selection of Halogenic Electrolyte Additive Engineering for Rechargeable Batteries
Authors: Zheng Qiyu , Wang Yang , Liu Liang , Li Wei , Li Linyue , Li Shixuan , Wang Zhoulu , Zhang Yi , Wu Yutong , Wang Di , Liu Xiang 
Published: February 2023

AbstractElectrolyte additives have been widely used to solve critical problems of electrodes and electrolytes in various rechargeable batteries. However, due to the lack of well‐directed strategy, the selection for additives have consumed considerable efforts of researchers. In this study, a diversity‐driven electrolyte additive of 5‐bromo‐2‐(difluoro(3,4,5‐trifluorophenoxy)methyl)‐1,3‐difluorobenzene (BDTMD) is directed synthesized, two different substituent groups are designed in the structure. With this newly‐formulated electrolyte, the overpotential during the charging process of Li−CO2 cells can be reduced to 3.8 V without any catalyst. Li metal electrode also shows a stable solid electrolyte interface layer and long cycling life of 1600 h. Based on the synergistic effect between F and Br, this study demonstrates an efficiently and well‐directed strategy to synthesis electrolyte additives.