bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of allergic phenotype in patients with eosinophilic oesophagitis: management protocol proposal
Authors: Domenech Witek Joan , Gonzalez Mendiola Rosario , Jover Cerdá Vicente , Pereira González Javier , Carballas Vázquez Clara , Villas Martínez Felicitas , Rodríguez Pacheco Ramón 
Published: February 2023

AbstractThere is a profile of patient with eosinophilic oesophagitis and atopic background, marked by the existence of IgE-mediated sensitizations. Our aim is to report the observed sensitivities to environmental and food allergens and panallergens in patients with eosinophilic oesophagitis with atopic background as well as characterizing other markers or analytical parameters. We suspect that the prevalence of sensitization to panallergens will be high and this will probably be relevant in terms of the onset and clinical course of the disease. We collated clinical and analytical data from 160 adult patients with a reported diagnosis of eosinophilic oesophagitis. These patients were studied between 1 January 2012 and 31 December 2020. During an initial visit skin tests were performed with full batteries of routine aero-allergens and foodstuffs. Patients were subsequently referred for blood test and determination of specific IgE, blood count and total IgE (in all cases), as well as eosinophilic cation protein and IMMUNOISAC in the centres in which this was available. We were able to detect a broad spectrum of sensitizations to environmental, foodstuffs and panallergens. The most common allergic disease was rhinoconjuntivitis. The sensitizations observed to foodstuffs were atypical for the adult population and were not responsible for manifestations compatible with immediate allergy. An important percentage of patients presented seasonal worsening of choking symptoms. We should be able to identify patients with eosinophilic oesophagitis and atopic background. Identifying this phenomenon would enable giving dietary and environmental recommendations as well as more specific and effective treatments to our patients.
Effects of phytosterol supplementation on lipid profiles in patients with hypercholesterolemia: a systematic review and meta-analysis of randomized controlled trials
Authors: Gao Yusi , Xun Ruilong , Xia Jiayue , Xia Hui , Sun Guiju 
Published: February 2023

Meta-analysis results showed that dietary phytosterols can help reduce TC and LDL-C concentrations in hypercholesterolemia patients without affecting HDL-C and TG, which were related to many factors. Dose is an important factor affecting LDL-C level.
Stabilization of alkaline 5-HMF electrolytes via Cannizzaro reaction for the electrochemical oxidation to FDCA
Authors: Krebs Moritz Lukas , Bodach Alexander , Wang Changlong , Schüth Ferdi 
Published: February 2023

This work investigates the degradation of 5-hydroxymethylfurfural (HMF) in an alkaline electrolyte, enabling “indirect” electrooxidation of HMF at unprecedentedly high substrate and base concentrations at improved atom economy.
A review on a novel method for aging evaluation of transformer insulating paper based on methanol
Authors: Chen Qingguo , Sun Wei , Cheng Song , Huang Guokai 
Published: February 2023

AbstractThe insulation paper is a crucial factor for evaluating the insulation status of transformers. The traditional evaluation methods for insulation paper are dissolved gas component content analysis (CO and CO2) and furfural (2‐FAL) content analysis in oil. The detection principle of the former leads to its low accuracy, while the field application effect of the latter is not ideal due to the easy oxidation of furfural and low content. Methanol, result of its good stability and high production compared with other marker products (CO, CO2, 2‐FAL) has been investigated as a novel marker for aging evaluation of transformer insulating paper in recent years. The results of the investigation indicated that there is a good correlation between the content of methanol in oil and the degree of polymerization under laboratory conditions, which reflected the insulation aging state of the transformer insulating paper more accurately. This paper summarizes the current research status of methanol formation mechanism, detection methods and aging evaluation in insulating oil, and points out the key problems to be solved and development prospects, hoping to provide relevant reference for aging evaluation of oil immersed power transformer.
Retinex‐inspired contrast stretch and detail boosting for lowlight image enhancement
Authors: Lu Haoxiang , Liu Zhenbing , Lan Rushi , Pan Xipeng , Gong Junming 
Published: February 2023

AbstractLowlight images with low brightness and contrast, blurry details usually bring us an uncomfortable visual experience. To promote the quality of these deviation images, this paper presents a new and efficient approach, named MFMR, for enhancing lowlight images in the hue‐saturation‐value (HSV) colour space. Concretely, the multi‐angle filter is first applied to estimate the artifact‐free illumination and reflection component of the V‐channel. Afterward, the adaptive bi‐interval histogram with human visual characteristics and morphological operations is employed to process the former, adaptive gamma correction to process the latter for generating various feature maps. In the end, these feature maps are united via adaptive multi‐scale fusion strategy to reconstruct high‐quality images, which are characterized by high contrast and brightness, vivid colour, and clearer details. Extensive experiments show that this method is a well‐proven low‐light image enhancement approach, which outperforms the state‐of‐the‐art comparison methods. Furthermore, the proposed method also can yield satisfying images in the heavy foggy, yellow sand, underwater, and other severe conditions.
Manta ray foraging optimization algorithm‐based load frequency control for hybrid modern power systems
Authors: Sobhy Mohamed A. , Hasanien Hany M. , Abdelaziz Almoataz Y. , Ezzat Mohamed 
Published: February 2023

AbstractThe regulation of the frequency and line power flow in interconnected power networks is considered to be a key aspect of load frequency control (LFC). This article broaches a modern power network composed of three interconnected control areas including traditional generation units taking into account non‐linearities, also renewable energy sources (RESs) and energy storage (ES) units are involved in the power grid paradigm. Two forms of RESs are included in the analysis, which are photovoltaic (PV) and wind power plants. In addition, the study framework involves three types of ES units, which are batteries of plug‐in electric vehicles (PEVs), flywheel energy storage system (FESS) and capacitive energy storage system (CESS). In this analysis, LFC is accomplished by the use of proportional‐integral‐derivative (PID) controllers in the system control loops. A recent optimization algorithm called Manta Ray Foraging optimization (MRFO) is employed to obtain the optimal gain configuration of the controllers. Real site measurements are imported to the RESs involved in the study aiming to examine the proposed control scheme under realistic conditions. Compared with other rival algorithms, the effectiveness of the MRFO‐based PID controller is validated. Simulation results confirm the efficacy of the proposed control scheme. The findings also ensure the role of ES units in optimizing the time‐domain responses. The main contributions of this paper are applying a new metaheuristic optimization algorithm to solve the LFC problem and introducing a new criteria for judging the system performance in compliance with the harmonic spectrum of the responses in the frequency domain. The results of the simulation are retrieved through a MATLAB model.
New multi‐operational multi‐port DC–DC converter with bidirectional capability
Authors: Jalilzadeh Tohid , Rostami Naghi 
Published: February 2023

AbstractA new triple‐input DC–DC converter with bidirectional ability is proposed in this paper. This converter is an interface between two unidirectional ports, one bidirectional port for the battery, and a DC link. This makes the proposed converter suitable for hybrid energy systems (HES). The load power can be provided by each input source separately or simultaneously. Also, the battery can be charged by input sources as well as with the energy returned from the output. These features provide a high degree of flexibility for the proposed converter. Boost and buck‐boost operation and low‐voltage stress on semiconductors are other advantages of the proposed converter. The performance of the converter in continuous conduction mode (CCM) is given along with the governing mathematical equations. The experimental results on a laboratory prototype confirm the theoretical calculations.
Using the “least-deflected” subsamples of ultra-high energy cosmic rays to constrain source population(s)
Authors: Sotomayor Webar Matías , Nagar Neil M. , Finlez Carolina 
Published: February 2023

Context. The source population(s) of ultra-high energy cosmic rays (UHECRs) with energies of ≥57 × 1018 eV (57 EeV) are still unknown and continue to be a subject of debate. The published arrival directions and energies of 303 UHECRs from the Pierre Auger Observatory and Telescope Array enable correlations with astronomical sources. However, deflections of UHECRs in the Galactic Magnetic Field (GMF) can be considerable, especially for heavy UHECR compositions.
Aims. We aim to constrain the source(s) of UHECRs by focusing on the subset of UHECRs that experience minimal deflections by the Galactic magnetic field (GMF).
Methods. We used Monte Carlo simulations of UHECR trajectories in a total of eight posited GMF models (and six UHECR compositions from H to Fe) to identify two subsamples of about 40 UHECRs. The H compositions of these subsamples suffer deflections of less than a few degrees in one (or most) of the GMFs. Both the total UHECR sample and the “least-deflected” (vs. the remaining “more-deflected”) subsamples of UHECRs were cross-correlated with catalogs of astronomical sources (at D ≲ 100 Mpc) and neutrino arrival directions.
Results. For H compositions, the full sample of UHECRs is most closely correlated with Cen A, nearby (< 75 Mpc) radiogalaxies, and optically selected active galactic nuclei (AGNs); the least-deflected sub sample shows a most consistent correlation with nearby (D ≲ 25 Mpc) galaxies, although some GMF models show a preference for the IceCube muon-neutrino arrival detections. For oxygen compositions, the out-of-galaxy arrival directions of least-deflected UHECRs fall on the extragalactic plane (and thus close to nearby galaxies) in many GMFs. For Fe compositions, the out-of-galaxy UHECR arrival directions typically originate in a region ∼30 deg offset from Cen A, except in the case of the JF12 model; this offset can be decreased by re-scaling (by ∼50%) the magnitudes of the dipole and disk fields of the relevant GMFs.
ThePlanckclusters in the LOFAR sky
Authors: Bruno L. , Brunetti G. , Botteon A. , Cuciti V. , Dallacasa D. , Cassano R. , van Weeren R. J. , Shimwell T. , Taffoni G. , Russo S. A. , Bonafede A. , Brüggen M. , Hoang D. N. , Rottgering H. J. A. , Tasse C. 
Published: February 2023

Context.Extended radio sources in the sky require a dense sampling of short baselines to be properly imaged by interferometers. This problem arises in many areas of radio astronomy, such as in the study of galaxy clusters, which may host megaparsec-scale diffuse synchrotron sources in the form of radio halos. In clusters where no radio halos are detected, owing to intrinsic absence of emission or extrinsic (instrumental and/or observational) effects, it is possible to determine upper limits.Aims.We consider a sample ofPlanckgalaxy clusters from the Second Data Release of the LOFAR Two Meter Sky Survey (LoTSS-DR2) where no radio halos are detected. We aim to use this sample to test the capabilities of LOFAR to recover diffuse extended emission and derive upper limits.Methods.Through the injection technique, we simulated radio halos with various surface brightness profiles. We then predicted the corresponding visibilities and imaged them along with the real visibilities. This method allows us to test the fraction of flux density losses owing to inadequateuvcoverage and obtain thresholds at which the mock emission becomes undetectable by visual inspection.Results.The denseuvcoverage of LOFAR at short spacings allows us to recover ≳ 90% of the flux density of targets with sizes up to ~15′. We find a relation that provides upper limits based on the image noise and extent (in terms of number of beams) of the mock halo. This relation can be safely adopted to obtain upper limits without injecting when artefacts introduced by the subtraction of the discrete sources are negligible in the central region of the cluster. Otherwise, the injection process and visual inspection of the images are necessary to determine more reliable limits. Through these methods, we obtain upper limits for 75 clusters to be exploited in ongoing statistical studies.
Polarisation of molecular lines in the circumstellar envelope of the post-asymptotic giant branch star OH 17.7–2.0
Authors: Vlemmings W. H. T. , Tafoya D. 
Published: February 2023

Context. The role of magnetic field in shaping planetary nebulae (PNe), either directly or indirectly after being enhanced by binary interaction, has long been a topic of debate. Large-scale magnetic fields around pre-PNe have been inferred from polarisation observations of masers. However, because masers probe very specific regions, it is still unclear if the maser results are representative of the intrinsic magnetic field in the circumstellar envelope (CSE).
Aims. Molecular line polarisation of non-maser lines can provide important information about the magnetic field. A comparison between the magnetic field morphology determined from maser observations and that observed in the more diffuse CO gas can reveal if the two tracers probe the same magnetic field.
Methods. We compared observations taken with the Atacama Large Millimeter/submillimeter Array (ALMA) of molecular line polarisation around the post-asymptotic giant branch (post-AGB) or pre-PN star OH 17.7−2.0 with previous observations of polarisation in the 1612 MHz OH maser region. Earlier mid-infrared observations indicate that OH 17.7−2.0 is a young bipolar pre-PN, with both a torus and bipolar outflow cavities embedded in a remnant AGB envelope.
Results. We detect CO J = 2 − 1 molecular line polarisation at a level of ∼4% that displays an ordered linear polarisation structure. We find that, correcting for Faraday rotation of the OH maser linear polarisation vectors, the OH and CO linearly polarised emission trace the same large-scale magnetic field. A structure function analysis of the CO linear polarisation reveals a plane-of-the-sky magnetic field strength of B⊥ ∼ 1 mG in the CO region, consistent with previous OH Zeeman observations.
Conclusions. The consistency of the ALMA CO molecular line polarisation observation with maser observations indicate that both can be used to determine the magnetic field strength and morphology in CSEs. The new observations indicate that the magnetic field has a strong toroidal field component projected on the torus structure and a poloidal field component along the outflow cavity. The existence of a strong, ordered, magnetic-field around OH 17.7−2.0 indicates that the magnetic field is likely involved in the formation of this bipolar pre-PN.
Interferon-γ-Treated Mesenchymal Stem Cells Modulate the T
Cell-Related Chemokines and Chemokine Receptors in an Animal Model of
Experimental Autoimmune Encephalomyelitis
Authors: Ahmadifard Reza , Jafarzadeh Abdollah , Mahmoodi Merat , Nemati Maryam , Rahmani Mehdi , Khorramdelazad Hossein , Ayoobi Fatemeh 
Published: February 2023

Abstract
Background Mesenchymal stem cells (MSCs) modulate immune responses, and
their immunomodulatory potential can be enhanced using inflammatory cytokines.
Here, the modulatory effects of IFN-γ-licensed MSCs on expression of T
cell-related chemokines and chemokine receptors were evaluated using an
experimental autoimmune encephalomyelitis (EAE) model.
Material and Methods EAE was induced in 3 groups of C57bl/6 mice
and then treated with PBS, MSCs and IFN-γ-treated MSCs. The EAE
manifestations were registered daily and finally, the brain and spinal cords
were isolated for histopathological and gene expression studies.
Results The clinical scores were lowered in MSCs and
IFN-γ-licensed MSCs groups, however, mice treated with
IFN-γ-licensed MSCs exhibited lower clinical scores than MSCs-treated
mice. Leukocyte inﬁltration into the brain was reduced after treatment
with MSCs or IFN-γ-licensed MSCs compared to untreated group
(P<0.05 and P<0.01, respectively). In comparison with untreated
EAE mice, treatment with MSCs reduced CCL20 expression (P<0.001) and
decreased CXCR3 and CCR6 expression (P<0.02 and P<0.04,
respectively). In comparison with untreated EAE mice, treatment with
IFN-γ-licensed MSCs reduced CXCL10, CCL17 and CCL20 expression
(P<0.05, P<0.05, and P<0.001, respectively) as well as
decreased CXCR3 and CCR6 expression (P<0.002 and P<0.02,
respectively), whilst promoting expression of CCL22 and its receptor CCR4
(P<0.0001 and P<0.02, respectively). In comparison with
MSC-treated group, mice treated with IFN-γ-licensed MSCs exhibited lower
CXCL10 and CCR6 expression (P<0.002 and P<0.01, respectively),
whereas greater expression of CCL22 and CCR4 (P<0.0001 and
P<0.01, respectively).
Conclusion Priming the MSC with IFN-γ can be an efficient approach
to enhance the immunomodulatory potential of MSCs.
The Influence of Daily Exercise on Muscle Echo Intensity and Stiffness in Young Women
Authors: Yoshiko Akito , Mitsuyama Hirohito , Kuramochi Rieko , Ohta Megumi 
Published: February 2023

AbstractThis study aimed to investigate the effect of daily exercise on skeletal muscle function, size, and quality in young women. Twenty-six young women participated in this study, categorized into daily exercise and non-exercise groups. The exercise group had performed exercise or training three times a week for more than six months. Knee extension and flexion, plantar flexion, and dorsiflexion peak torques were measured for muscle function. B-mode ultrasound images were taken from the thigh and calf, and muscle thickness and echo intensity were measured in the vastus lateralis and medial gastrocnemius. Shear modulus at different joint angles of the knee (0° [full extended], 40°, and 90°) and ankle (40 °plantarflexion, 0° [neutral], and 10° dorsiflexion) was measured from the vastus lateralis and medial gastrocnemius to determine muscle stiffness. Peak torque and echo intensity did not significantly differ between the exercise and non-exercise groups. Shear modulus in the medial gastrocnemius at 10° dorsiflexion was significantly lower in the exercise group compared with the non-exercise group (34.2±7.7 vs. 46.5±13.1 kPa, P<0.05). These results suggest that daily exercise and training could affect muscle stiffness, but do not lead to an increase in muscle function.
Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study
Authors: Mangira Dileep , Raftopoulos Spiro , Vogrin Sara , Hartley Imogen , Mack Alexandra , Gazelakis Kathryn , Nalankilli Kumanan , Trinh Andrew , Metz Andrew J. , Appleyard Mark , Grimpen Florian , Elliott Timothy , Brown Gregor , Moss Alan 
Published: February 2023

Background Cold snare polypectomy (CSP) is the standard of care for the resection of small (< 10 mm) colonic polyps. Limited data exist for its efficacy for medium-sized (10–19 mm) nonpedunculated polyps, especially conventional adenomas. This study evaluated the effectiveness and safety of CSP/cold endoscopic mucosal resection (C-EMR) for medium-sized nonpedunculated colonic polyps.
Methods A prospective multicenter observational study was conducted of all morphologically suitable nonpedunculated colonic polyps of 10–19 mm removed by CSP/C-EMR between May 2018 and June 2021. Once resection was complete, multiple biopsies were taken of the margins circumferentially and centrally. The primary outcome was the incomplete resection rate (IRR), based on residual polyp in these biopsy specimens. Secondary outcomes were recurrence rate at first surveillance colonoscopy and rates of adverse events (AEs).
Results CSP/C-EMR was performed for 350 polyps (median size 15 mm; 266 [76.0 %] Paris 0-IIa classification) in 295 patients. Submucosal injection was used for 87.1 % (n = 305) of polyps. Histology showed 68.6 % adenomas, 26.0 % sessile serrated lesions (SSLs) without dysplasia, 4.0 % SSL with dysplasia, and 1.4 % hyperplastic polyps. The IRRs based on margin or central biopsies being positive were 1.7 % (n = 6) and 0.3 % (n = 1), respectively. The polyp recurrence rate was 1.7 % (n = 4) at first surveillance colonoscopy – completed for 65.4 % (n = 229) of polyps at a median interval of 9.7 months. AEs occurred in 3.4 % (n = 10) of patients: four with post-polypectomy pain; three self-limiting post-polypectomy bleeds; two post-polypectomy-syndrome-like presentations; and one intraprocedural bleed treated with clips. There were no perforations.
Conclusion CSP/C-EMR for morphologically suitable nonpedunculated colonic polyps of 10–19 mm is effective and safe, including for conventional adenomas. Rates of incomplete resection and recurrence were low, with few AEs. Studies directly comparing this method with hot snare resection are required.
Synthesis of 2‑Boryl Allylboronates by a Bimetallic Platinum/Zinc-Promoted Diborylation of Propargylic Amines
Authors: Zhuo Chun-Xiang , Shi Xiao-Nan , Wang Jia-Le , Wu Jiang-Bin 
Published: February 2023

Abstract2‑Boryl allylboronates, which contain both a C(sp2)–B bond and a C(sp3)–B bond, are attractive synthetic intermediates due to their diverse reactivity profiles toward a wide range of organic transformations. We report a facile approach to (Z)-2‑boryl allylboronates through a Pt/Zn-promoted diborylation reaction of readily available propargylic amines. An array of valuable (Z)-2‑boryl allylboronates were obtained in up to 73% yield in the presence of 2.5 mol% of Pt(PPh3)4 and 50 mol% of ZnBr2.