bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine-Mapping and Credible Set Construction using a Multi-population Joint Analysis of Marginal Summary Statistics from Genome-wide Association Studies
Authors: Shen Jiayi , Jiang Lai , Wang Kan , Wang Anqi , Chen Fei , Newcombe Paul J. , Haiman Christopher A. , Conti David V. 
Published: December 2022

AbstractRecent advancement in Genome-wide Association Studies (GWAS) comes from not only increasingly larger sample sizes but also the shifted focus towards underrepresented populations. Multi-population GWAS may increase power to detect novel risk variants and improve fine-mapping resolution by leveraging evidence from diverse populations and accounting for the difference in linkage disequilibrium (LD) across ethnic groups. Here, we expand upon our previous approach for single-population fine-mapping through Joint Analysis of Marginal SNP Effects (JAM) to a multi-population analysis (mJAM). Under the assumption that true causal variants are common across studies, we implement a novel version of JAM that conditions on multiple SNPs while explicitly incorporating the different LD structures across populations. The mJAM framework can be used to first select index variants using the mJAM likelihood with any feature selection approach. In addition, we present a novel approach leveraging the ideas of mediation to construct credible sets for these index variants. Construction of such credible sets can be performed given any existing index variants. We illustrate the implementation of the mJAM likelihood through two implementations: mJAM-SuSiE (a Bayesian approach) and mJAM-Forward selection. Through simulation studies based on realistic effect sizes and levels of LD, we demonstrated that mJAM performs better than other existing multi-ethnic methods for constructing concise credible sets that include the underlying causal variants. In real data examples taken from the most recent multi-population prostate cancer GWAS, we showed several practical advantages of mJAM over other existing methods.
Autophagy inspects Rim4-mRNA interaction to safeguard programmed meiotic translation
Authors: Zhang Rudian , Feng Wenzhi , Qian Suhong , Li Shunjin , Wang Fei 
Published: December 2022

AbstractAutophagy can degrade RNA, with an intricate preference for specific RNAs. However, the mechanism remains unclear. During yeast meiosis, autophagy is active, while a subset of transcripts needs to survive until their programmed translation during and at the end of meiotic divisions. Thus, the challenge here is how meiotic autophagy temporally spares specific mRNAs. Rim4, a meiosis-specific RNA binding protein (RBP), sequesters a specific set of mid-late meiotic transcripts during early meiosis to suppress premature translation. Recently, we reported that autophagy degrades Rim4, while the underlying mechanism and the fate of transcripts in complex with Rim4 remain uncharacterized. Here, we show that Rim4 utilizes a nuclear localization signal (NLS) to enter the nucleus to load its mRNA substrates before the nuclear export. Once in the cytoplasm, the active autophagy spares Rim4-mRNA. Using combined genetic, biochemical, and cell imaging approaches, we show that autophagy selectively degrades Rim4 during meiotic divisions in an Atg11-dependent manner upon Rim4-bound mRNAs released for translation; meanwhile, released mRNAs also become sensitive to autophagy.In vitro, purified Rim4 and its RRM-motif-containing variants, but not Rim4-mRNA complex, activate Atg1 kinase activity in meiotic cell lysates and in the immunoprecipitated Atg1 complex, suggesting that the conserved RRMs are involved in stimulating Atg1 and hence selective autophagy. These findings indicate that autophagy inspects Rim4-mRNA interaction to ensure meiotic stage-specific translation.
Mechanism of ATP hydrolysis dependent rotation of ATP synthases
Authors: Nakano Atsuki , Kishikawa Jun-ichi , Mitsuoka Kaoru , Yokoyama Ken 
Published: December 2022

AbstractF1domain of ATP synthase is a rotary ATPase complex in which rotation of central γ-subunit proceeds in 120° steps against a surrounding α3β3fueled by ATP hydrolysis. How the ATP hydrolysis reactions occurring in three catalytic αβ dimers are coupled to mechanical rotation is a key outstanding question. Here we describe catalytic intermediates of the F1domain during ATP mediated rotation captured using cryo-EM. The structures reveal that three catalytic events and the first 80° rotation occur simultaneously in F1domain when nucleotides are bound at all the three catalytic αβ dimers. The remaining 40° rotation of the complete 120° step is driven by completion of ATP hydrolysis at αDβD, and proceeds through three sub-steps (83°,91°,101°, and120°) with three associated conformational intermediates. All sub-steps except for one between91°and101°associated with phosphate release, occur independently of the chemical cycle, suggesting that the 40° rotation is largely driven by release of intramolecular strain accumulated by the 80° rotation. Together with our previous results, these findings provide the molecular basis of ATP driven rotation of ATP synthases.
Exploring the integration of blockchain technology into supply chain: challenges and performance
Authors: Ghode Dnyaneshwar Jivanrao , Yadav Vinod , Jain Rakesh , Soni Gunjan 
Published: December 2022

PurposeIn the era of digitization, blockchain technology (BCT) has gained huge attraction in a variety of business processes including operations and supply chains (SC) of different industrial sectors. This paper aims that the adoption of BCT in SC enables the industries to integrate the stakeholders and its distinct features enhance the performance of SC.Design/methodology/approachAn attempt is made to develop a BCT platform a pilot case of bearing-SC and identify the challenges and their solutions in the integration of BCT with SC. Moreover, the impact of BCT on measures of SC performance is also studied.FindingsThe results show enhanced transparency in the transactions, better security of the data, diminished latency period for transfer of information, improved traceability of the bearing, reduced time for payment transfer process and decreased nonvalue-added activities. Ultimately, overall trust of the customer can be improved by the integration of BCT in bearing-SC.Originality/valueIn the same way, BCT can be applied to SC of other components to assure the product quality to the end-users.
Women entrepreneurs during COVID-19 pandemic: does their social capital matter?
Authors: Tiwari Divya , Shastri Shruti 
Published: December 2022

PurposeThe purpose of this study is to the role of bonding and bridging social capital of women entrepreneurs in dealing with the business crisis induced by the COVID-19 pandemic.Design/methodology/approachA total of 24 women entrepreneurs from Deoria district from the state of Uttar Pradesh in India are selected through the snowball sampling technique. Out of these 24 female entrepreneurs, 14 belong to some network and 10 are not a part of any network. A qualitative methodology based upon in-depth personal interviews is used to get insights about the personal views of the female entrepreneurs on the role played by their bonding and bridging social capital to deal with the problems during the current business crisis.FindingsContrary to the general belief that women-owned businesses succumb easily to business crises and respond to reduce risks, the findings suggest that women business owners confidently faced the adverse business conditions. The bonding social capital of women entrepreneurs provided emotional support and motivation through internal interactions and responsibility sharing, and business networks (bridging capital) facilitated identification of new opportunities. The respondents emphatically mentioned the role of peer entrepreneurs as sources of information and resources.Originality/valueTo the best of the authors' knowledge, this is the first study in the Indian context that seeks to investigate the role of bonding and bridging social capital during the business crisis induced by the current pandemic using qualitative data generated through in-depth interviews.
Exploring measures to enhance the low adoption rate of IR 4.0 technologies: a qualitative inquiry with hotels during COVID-19
Authors: Osei Benjamin Appiah , Ragavan Neethiahnanthan Ari , Kandappan Balasubramanian , Frempong Foster 
Published: December 2022

PurposeWhile there was heightened awareness on the technologies of the fourth industrial revolution (IR 4.0) prior to COVID-19, studies have shown that the adoption of these advanced technologies (e.g. Big Data, robotics, Internet of Things, etc.) continues to remain low across global industries. This qualitative study sought to explore the reasons for the low rate of adoption of these technologies and appropriate measures to enhance their adoption at hotels, through the lens of hotel executives.Design/methodology/approachBased on interpretivist's ideals, this study follows a case study design and adopts a qualitative method of enquiry. The heterogenous purposive sampling technique was employed to gather data for the study, using semi-structured interviews.FindingsGrounded on the technology-organisation-environment (TOE) framework, the thematic analysis revealed technology, organisation and environment-related reasons for the low rate of IR 4.0 technologies adoption at hotels in Malaysia. Also, the study uncovered some interesting measures that will enhance the adoption of these advanced technologies at hotels.Originality/valueThis study unearths technology, organisation and environment-related reasons for low adoption, and measures to enhance the adoption of IR 4.0 technologies in hotels. This study also enlightens hotel owners and technology providers about practical issues that will ensure the successful adoption of such technologies to enhance hotel business. In line with SDG 9, this study also seeks to promote sustainable innovation in the hospitality industry. Practical and theoretical implications have also been discussed in this study.
Shifting language ideologies and pedagogies to be anti-racist: a reconstructive discourse analysis of one ELA teacher inquiry group
Authors: Schieble Melissa , Vetter Amy , Monét Martin Kahdeidra 
Published: December 2022

PurposeThis paper aims to present findings from a three-year qualitative study that used a model of teacher learning referred to as teaching as inquiry (Manfra, 2019). Teaching as inquiry centers the teacher as a learner in a prolonged and “systematic process of data collection and analysis focused on changing teaching” (p. 167). Findings from the larger qualitative study demonstrate the work of collecting transcripts and using discourse analysis to analyze classroom discourse fostered high school English teachers’ knowledge and skills for facilitating critical conversations (Schiebleet al., 2020). For this paper, the authors highlight Paula, a white, female secondary teacher who is dual certified in English Language Arts and ESL. Findings from Paula’s case demonstrate the ways the teacher inquiry group disrupted Paula’s language ideologies of linguistic purism, an ideology embedded in white supremacist and colonialist, hegemonic language policies and practices (Kroskrity, 2004), and transformed her instructional practices over time.Design/methodology/approachThe research used qualitative methods for design and scope to generate an information-rich instrumental case study (Stake, 1995). Case study is a form of qualitative inquiry that concentrates on experiential knowledge of the case. This study used case study methods to construct an instrumental case to understand how participation in the teacher inquiry group shaped Paula’s facilitation of critical conversations. Data analysis used inductive and deductive qualitative coding procedures and discourse analysis (Gee, 2004; Rogers, 2018) to address the research questions.FindingsFindings demonstrate that prior to meeting with the teacher inquiry group, Paula’s teaching practices embodied linguistic separatism by emphasizing that standardized English was the “appropriate” way to participate in critical conversations. Through studying her classroom discourse, the inquiry group supported her to critically question these instructional practices and ideologies. Findings demonstrate that the work of the inquiry group supported her embodiment and articulation of a translanguaging ideology that supported her facilitation of critical conversations.Originality/valueFindings from this study contributes to scholarly and professional knowledge about how models of teaching as inquiry (Manfra, 2019) demonstrate a positive or reconstructive impact on teacher and student learning. This study highlights the potential for reconstructive shifts in the context of how teachers learn together and the tools that support them in doing so.
Perceived organizational politics and workplace gossip: the moderating role of compassion
Authors: Khan Aamna , Chaudhary Richa 
Published: December 2022

Purpose
This study aims to examine perceived organizational politics (POP) as an antecedent to workplace gossip. While the commonly held belief is that POP is consequential to the existence of negative workplace gossip, an alternate hypothesis can be that POP may predict positive workplace gossip as well. The study further explores the role of compassion as a boundary condition in the relationship of POP with negative and positive valences of workplace gossip.

Design/methodology/approach
Using purposive sampling technique, the data were collected through time-lagged (two-wave) surveys from employees working in private (Study 1, n = 366) and public (Study 2, n = 206) sector organizations across India, and analyzed using SPSS AMOS 27 and PROCESS Macro (Model 1).

Findings
The results of Study 1 and Study 2 revealed that POP correlated positively with negative as well as positive workplace gossip. Further, it was found that compassion moderated the relationship of POP with negative workplace gossip but failed to moderate in the case of positive workplace gossip in both the studies.

Practical implications
This study makes practitioners aware of the ubiquity of the phenomenon of workplace gossip and encourages them to embrace gossip in the workplace rather than banishing it altogether.

Originality/value
This study delineates the link between POP and the valences of workplace gossip that remains unexplored in the literature. The study also takes into account the intervening role of compassion in the aforementioned relationships. The striking results of the study open new realms of research possibilities not only in the field of workplace gossip, but POP and compassion as well.
How social interaction can prevent interpersonal conflict from inducing turnover intentions and diminishing championing behaviour
Authors: De Clercq Dirk , Belausteguigoitia Imanol 
Published: December 2022

Purpose
The purpose of this study is to draw from conservation of resources theory to examine how employees’ experience of resource-draining interpersonal conflict might diminish the likelihood that they engage in championing behaviour. Its specific focus is on the mediating effect of their motivation to leave the organization and the moderating effect of their peer-oriented social interaction in this connection.

Design/methodology/approach
The research hypotheses are empirically assessed with quantitative survey data gathered from 632 employees who work in a large Mexican-based pharmacy chain. The statistical analyses involved an application of the Process macro, which enabled concurrent estimations of the direct, mediating and moderating effects predicted by the proposed conceptual framework.

Findings
Emotion-based tensions in co-worker relationships decrease employees’ propensity to mobilize support for innovative ideas, because employees make plans to abandon their jobs. This mediating role of turnover intentions is mitigated when employees maintain close social relationships with their co-workers.

Practical implications
For organizational practitioners, this study identifies a core explanation (i.e. employees want to quit the company) for why frustrations with emotion-based quarrels can lead to a reluctance to promote novel ideas – ideas that otherwise could add to organizational effectiveness. It also highlights how this harmful process can be avoided if employees maintain good, informal relationships with their colleagues.

Originality/value
For organizational scholars, this study explicates why and when employees’ experience of interpersonal conflict translates into complacent work behaviours, in the form of tarnished idea championing. It also identifies informal peer relationships as critical contingency factors that disrupt this negative dynamic.
The Regional Comprehensive Economic Partnership (RCEP) for the Asia–Pacific region and world
Authors: Zreik Mohamad 
Published: December 2022

PurposeThe regional comprehensive economic partnership (RCEP) is promising as per the claims and can be revolutionary for the Asia–Pacific Region. The member countries will get a boost in the post-pandemic world due to the RCEP. According to Brookings, the RCEP is going to be an agreement reshaping the global economics. This study aims to clarify the aspects related to the RCEP and how it can boost global economics.Design/methodology/approachThe study employs qualitative descriptive analysis to address the status of RCEP in the region and the consequences of such main transnational partnership. The study is based on economic reports, official documents and data directly related to the subject of the study.FindingsFindings show that the RCEP will be a significant driver of regional trade despite its faults. The RCEP's tariff benefits and rules of origin, notwithstanding their relatively restricted scope, will encourage enterprises to source products and services from RCEP members, and in combination, RCEP and Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) are anticipated to replace at least some competing US commodities, services and farm exports. For items that integrate parts and components from inside the area, such as from China, the RCEP is projected to reduce tax and trade facilitation costs, allowing enterprises to avoid US Section 301 tariffs.Originality/valueBy examining how the RCEP operates within the framework of domestic and international trade, this study contributes to a deeper understanding of RCEP and analyses its nature based on data and official reports.
Accounting for customer satisfaction: evidence of corporate performance value relevance from top global brands
Authors: AbuRaya Rania , Yassin Mohamed , Ali Salah A. 
Published: December 2022

Purpose
Customer satisfaction (CS) is a key factor in maintaining customer relations and achieving corporate success. This paper aims to empirically investigate the value relevance of CS accounting for corporate performance (CP) of top global brands worldwide.

Design/methodology/approach
A sample of top 100 global brands located in different countries and operating over various industries is examined for a period of three years comprising 2020 till 2022. A quantitative research methodology is used for conducting content analysis of companies’ annual reports and carrying out ordinary least squares multiple regression tests using different financial and market measures, as proxies for CP.

Findings
Results show that CS can significantly enhance CP. Findings indicate a significant positive association of current and lagged CS with both profitability and market value, thereby documenting consistent evidence in a global market setting.

Research limitations/implications
The study provides an aggregate picture of the value relevance of CS while a disaggregated view across different industries can reveal deeper insights. However, the study has important implications for corporate executives, investors, accountants and standard setters, offering global insights that appreciate CS for improving CP and creating value for businesses. It helps in understanding customers preferences, designing corporate policies and strategies, predicting CP, developing alternative methods of CS measurement and reporting and recommending possible accounting treatments.

Originality/value
This study adds to the relatively limited literature on the potential contribution of CS within the accounting literature. It extends the scope of prior research by documenting quantitative empirical evidence of the value relevance of CS for CP of top global brands, using different financial and market measures. It provides international insights into a global market setting, in which diversity is inherent and competition is fierce. Hence, the study largely contributes to resolving existing debate by documenting consistent objective evidence over a wide regional diversity using various indicators.
Can innovative work behaviour spur creativity while working remotely? The role of work–home conflict and social isolation
Authors: Garlatti Costa Grazia , Bortoluzzi Guido , Černe Matej 
Published: December 2022

Purpose
During the COVID-19 pandemic, huge numbers of employees shifted to remote working, with various consequences for their family and working lives. This study aims to focus on the factors that affect their creativity while working from home. As individual creativity is shaped by context, the authors investigate the moderating role of the domestic environment on employees’ creative contributions while working remotely.

Design/methodology/approach
The authors base the arguments on the complexity perspective on innovative work behaviour (IWB) and consider innovation a recursive process in which innovative behaviour can inform, and not simply follow, subsequent creative acts. The sudden spur of the pandemic interrupted the natural recursiveness of the creativity–innovation process and allowed them to empirically investigate the direct and indirect effects that levels of pre-pandemic IWB had on individuals’ creative behaviour. The authors hypothesise that this relationship is moderated by two resource-conserving contextual factors: work–home conflict and a feeling of social isolation. The participants were 803 employees from several Italian corporations. The data were collected during the first lockdown period (April–May 2020).

Findings
The findings support the existence of a three-way interaction, suggesting that IWB affects further creative behaviours when both work–home conflict and social isolation are low.

Originality/value
To the best of the authors’ knowledge, this is the first study that investigates what happened to employees’ creativity during the COVID-19 massive remote working situation. The results should be interpreted beyond the unique context because remote working will continue.