bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salivary IL‐33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis
Authors: Yilmaz Mustafa , He Qiushui , Demir Esra , Teräsjärvi Johanna , Gürsoy Ulvi Kahraman 
Published: July 2023

AbstractObjectivesToll‐like receptor‐2 (TLR2) signalling pathway is involved in the regulation of interleukin (IL)‐33 and its receptor suppression of tumorigenicity‐2 (ST2). This study aimed to compare salivary IL‐33 and soluble ST2 (sST2) levels of periodontitis patients with those of periodontally healthy individuals in relation to their TLR2 rs111200466 23‐bp insertion/deletion polymorphism within the promoter region.Materials and MethodsUnstimulated saliva samples were collected, and periodontal parameters were recorded from 35 periodontally healthy individuals and 44 periodontitis patients. Non‐surgical treatments were applied to periodontitis patients, and sample collections and clinical measurements were repeated 3 months following therapy. Salivary IL‐33 and sST2 levels were measured with enzyme‐linked immunosorbent assay kits, and TLR2 rs111200466 polymorphism was detected by polymerase chain reaction.ResultsElevated salivary IL‐33 (p = 0.007) and sST2 (p = 0.020) levels were observed in periodontitis patients, in comparison to controls. sST2 levels declined 3‐months following treatment (p < 0.001). Increased salivary IL‐33 and sST2 levels were found to be associated with periodontitis, with no significant relation to the TLR2 polymorphism.ConclusionPeriodontitis, but not TLR2 rs111200466 polymorphism, is associated with elevated salivary sST2 and possibly IL‐33 levels, and periodontal treatment is effective in reducing salivary sST2 levels.
Severe Symptomatic Epidural Hematoma Following Percutaneous Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo‐ULBD)—Series Report and Management Strategies
Authors: Lin Antao , Meng Shengwei , Wang Chao , Zhao Xiaodan , Han Shuo , Zhang Hao , Shen Yanqing , Zhu Kai , Zhou Dan , Su Kunpeng , Ma Xuexiao , Zhou Chuanli 
Published: July 2023

ObjectivesSevere symptomatic epidural hematoma (SSEH) is one of the most severe complications following percutaneous endoscopic unilateral laminectomy for bilateral decompression (Endo‐ULBD). Considering that this technique has been performed for a short time, no detailed reports have been recently published. Thus, it is critical to gain a better understanding of SSEH occurring in its postoperative period with regard to its incidence, possible causes, outcome, etc., in order to identify relevant management strategies.MethodsPatients with spinal stenosis who had undergone Endo‐ULBD in our department from May 2019 to May 2022 were retrospectively analyzed. Of which, patients with postoperative epidural hematoma were followed‐up. The preoperative and postoperative physical conditions of each patient were recorded, and the information related to hematoma removal surgery was recorded in detail. Clinical outcomes were assessed using the visual analogue scale (VAS) and Oswestry disability index (ODI), and the results were classified into “excellent,” “good,” “fair,” or “poor” based on the modified MacNab criteria. The incidence of hematoma with different factors was calculated, and a bar graph was used to compare the difference of the indexes related to hematoma removal between cases, and a line graph was used to reflect the trend of the outcome of each patient within 6 months to evaluate the effect of the treatment.ResultsA total of 461 patients with spinal stenosis who underwent Endo‐ULBD were enrolled in the study. SSEH occurred in four cases, with an incidence rate of 0.87% (4/461). All these four patients underwent decompression of multiple segments, and three of them had a history of hypertension comorbid with diabetes. Notably, one patient had a past history of hypertension and coronary artery disease and was on postoperative low molecular heparin due to lower extremity venous thrombosis. According to the conditions of the four patients, three types of treatment were used. And with timely treatment, all patients recovered well.ConclusionDespite being a minimally invasive technique, postoperative epidural hematoma remains a severe complication of Endo‐ULBD. Therefore, during percutaneous endoscopic surgery, it is essential to enhance the comprehensive perioperative management of patients with Endo‐ULBD. Signs related to postoperative hematoma must be recognized and promptly managed. If necessary, satisfactory results can be achieved by using percutaneous endoscopy along the original surgical channel to remove the hematoma.
Tibial Tubercle‐Trochlear Groove Distance Has Better Diagnostic Reliability Than Tubercle‐Posterior Cruciate Ligament Distance For Predicting Patellar Instability: A Systematic Review
Authors: Zhang Lei , Tian Ming , Wu Shuang , Xu Tianhao , Zhang Kaibo , Xie Xing , Fu Weili 
Published: July 2023

ObjectiveThe tibial tubercle‐trochlear groove (TT‐TG) distance is now routinely utilized to help determine whether a realignment procedure is necessary for patients with patellar instability. The tibial tubercle‐posterior cruciate ligament (TT‐PCL) distance has been explored as an alternative measurement. The aim of this study is to compare the reliability of TT‐TG and TT‐PCL; to explore whether there is a relationship between the TT‐PCL and the TT‐TG distance; to determine whether there is a relationship between the TT‐TG and TT‐PCL distances and knee rotation; and to compare the abilities of the TT‐PCL distance and the TT‐TG distance with predicted patellar instability.MethodThis systematic review was performed in accordance with PRISMA guidelines. Three databases, PubMed, EMBASE, and Cochrane Central Register of Controlled Trials, were searched from inception to September 2021 to identify clinical studies comparing TT‐TG and TT‐PCL distances to patellar instability. Data on patient baseline characteristics, TT‐TG and TT‐PCL distances, inter‐observer reliability, and area under the receiver‐operating characteristic curve (AUC) were recorded. The methodological quality of the studies was assessed using the quality assessment form recommended by the Agency for Healthcare Research and Quality (AHRQ).ResultTwenty studies were included in the final analysis, comprising 2330 knees from 2260 patients. The current study showed that TT‐TG and TT‐PCL have similar observer reliability. The inter‐ and intra‐observer reliability of TT‐TG ranged from 0.807 to 0.98 and 0.553 to 0.99, respectively. The inter‐ and intra‐observer reliability of TT‐PCL ranged from 0.553 to 0.99 and 0.88 to 0.981, respectively. Six studies compared the AUC for predicting patellar instability and showed that TT‐TG had better predictive performance than TT‐PCL. Three studies reported a correlation between TT‐TG and knee rotation, but no such relationship was found for TT‐PCL. Eight studies reported a weak or moderate correlation between TT‐TG and TT‐PCL.ConclusionTT‐TG and TT‐PCL have similar inter‐ and intra‐rater reliability (as measured by ICC), but TT‐TG has greater discriminatory power to predict patellar instability than TT‐PCL (as measured by AUC values and odds ratio). However, considering trochlear dysplasia and individual variations, future studies need to find more accurate and individualized methods to predict patellar instability.
Biofire pneumonia panel in lung donors: faster detection but limited pathogens
Authors: Nguyen Anh , Chen Joy , Isaza Erin , Panchal Niel , Deiter Fred , Hoover Jonathan , Trinh Binh , Hays Steve R. , Golden Jeffrey A. , Singer Jonathan P. , Brzezinski Marek , Greenland John R. , Kukreja Jasleen 
Published: July 2023

AbstractBackgroundCulture of bronchoalveolar lavage (BAL) specimens takes time to report. We tested whether a molecular diagnostic test could accelerate donor lung assessment and treatment.MethodsWe compared BioFire Film Array Pneumonia Panel (BFPP) with standard of care (SOC) tests on lung allograft samples at three time points: (1) donor BAL at organ recovery, (2) donor bronchial tissue and airway swab at implantation, and (3) first recipient BAL following lung implantation. Primary outcomes were the difference in time to result (Wilcoxon signed‐ranked tests) and the agreement in results between BFPP and SOC assays (Gwet's agreement coefficient).ResultsWe enrolled 50 subjects. In donor lung BAL specimens, BFPP detected 52 infections (14 out of 26 pathogens in the panel). Viral and bacterial BFPP results were reported 2.4 h (interquartile range, IQR 2.0–6.4) following BAL versus 4.6 h (IQR 1.9–6.0, p = 0.625) for OPO BAL viral SOC results and 66 h (IQR 47–87, p < .0001) for OPO BAL bacterial SOC results. Although there was high overall agreement of results between BAL–BFPP versus OPO BAL–SOC tests (Gwet's AC p < .001 for all), the level of agreement differed among 26 pathogens designed in BFPP and differed by types of specimens. BFPP could not detect many infections identified by SOC assays.ConclusionsBFPP decreased time to detection of lung pathogens among donated lungs, but it cannot replace SOC tests due to the limited number of pathogens in the panel.
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The meso‐octoploid Heliophila variabilis genome sheds a new light on the impact of polyploidization and diploidization on the diversity of the Cape flora
Authors: Huang Yile , Guo Xinyi , Zhang Kang , Mandáková Terezie , Cheng Feng , Lysak Martin A. 
Published: July 2023

SUMMARYAlthough the South African Cape flora is one of the most remarkable biodiversity hotspots, its high diversity has not been associated with polyploidy. Here, we report the chromosome‐scale genome assembly of an ephemeral cruciferous species Heliophila variabilis (~334 Mb, n = 11) adapted to South African semiarid biomes. Two pairs of differently fractionated subgenomes suggest an allo‐octoploid origin of the genome at least 12 million years ago. The ancestral octoploid Heliophila genome (2n = 8x = ~60) has probably originated through hybridization between two allotetraploids (2n = 4x = ~30) formed by distant, intertribal, hybridization. Rediploidization of the ancestral genome was marked by extensive reorganization of parental subgenomes, genome downsizing, and speciation events in the genus Heliophila. We found evidence for loss‐of‐function changes in genes associated with leaf development and early flowering, and over‐retention and sub/neofunctionalization of genes involved in pathogen response and chemical defense. The genomic resources of H. variabilis will help elucidate the role of polyploidization and genome diploidization in plant adaptation to hot arid environments and origin of the Cape flora. The sequenced H. variabilis represents the first chromosome‐scale genome assembly of a meso‐octoploid representative of the mustard family.
Role of individual factor X concentrate pharmacokinetic studies in perioperative management of AL amyloidosis‐associated acquired factor X deficiency
Authors: Lewis Akeem R. , Peffley Nathan , Klompas Allan M. , Ashrani Aneel A. 
Published: July 2023

AbstractBackgroundAL amyloidosis is associated with acquired factor X (FX) deficiency. Experience related to its management is limited to case reports and series using prothrombin complex concentrate, fresh frozen plasma, plasma exchange, recombinant activated factor seven, and desmopressin with limited and variable efficacy. FX concentrate has not been widely used in its management.Study Design and MethodsWe report our experience with the perioperative use of FX concentrate (Coagadex) in two patients with AL amyloidosis‐associated acquired FX deficiency requiring surgery, using their individual pharmacokinetic studies to manage perioperative hemostasis. Pharmacokinetic studies involved obtaining post‐infusion FX activity at 10 min, 2, and 4 h following the administration of FX concentrate to calculate the FX half‐life.ResultsBoth patients' plasma FX activity was successfully increased to provide perioperative hemostatic support. Monitoring FX activity post‐surgery was also utilized to maintain FX activity levels to prevent post‐operative bleeding.ConclusionPharmacokinetic studies have a useful role in tailoring preoperative FX repletion in patients with AL amyloidosis associated with acquired FX deficiency.
THE GENERAL RESURRECTION AND EARLY MODERN NATURAL PHILOSOPHERS: A PRELIMINARY SURVEY
Authors: Henry John 
Published: July 2023

AbstractNoting that the doctrine of the general resurrection attracted renewed attention after the Reformation, and after the atomist revival led to the displacement of traditional hylomorphism by alternative matter theories, this article surveys the ways in which the resurrection was discussed by leading natural philosophers in seventeenth‐century England. These include discussion of how bodily resurrection might be possible, what resurrected bodies will be like; as well as the nature of living conditions after the resurrection. It is indicated that the resurrection seems to have played a much less prominent place in the writings of natural philosophers than the doctrine of the immortality of the soul, and other issues of natural theology. Reasons for this lack of prominence are tentatively offered, chiefly focusing on its unsuitability for combatting the perceived atheism of the time. It is hoped that this preliminary survey might inspire others to extend the survey, especially to cover Continental philosophers.
Lower systemic nitric oxide bioactivity, cerebral hypoperfusion and accelerated cognitive decline in formerly concussed retired rugby union players
Authors: Owens Thomas S. , Marley Christopher J. , Calverley Thomas A. , Stacey Benjamin S. , Fall Lewis , Tsukamoto Hayato , Iannetelli Angelo , Filipponi Teresa , Davies Bruce , Jones Gareth L. , Hirtz Christophe , Lehmann Sylvain , Tuaillon Edouard , Marchi Nicola , Bailey Damian M. 
Published: July 2023

AbstractFollowing retirement from sport, the chronic consequences of prior‐recurrent contact are evident and retired rugby union players may be especially prone to accelerated cognitive decline. The present study sought to integrate molecular, cerebrovascular and cognitive biomarkers in retired rugby players with concussion history. Twenty retired rugby players aged 64 ± 5 years with three (interquartile range (IQR), 3) concussions incurred over 22 (IQR, 6) years were compared to 21 sex‐, age‐, cardiorespiratory fitness‐ and education‐matched controls with no prior concussion history. Concussion symptoms and severity were assessed using the Sport Concussion Assessment Tool. Plasma/serum nitric oxide (NO) metabolites (reductive ozone‐based chemiluminescence), neuron specific enolase, glial fibrillary acidic protein and neurofilament light‐chain (ELISA and single molecule array) were assessed. Middle cerebral artery blood velocity (MCAv, doppler ultrasound) and reactivity to hyper/hypocapnia (/) were assessed. Cognition was determined using the Grooved Pegboard Test and Montreal Cognitive Assessment. Players exhibited persistent neurological symptoms of concussion (U = 109(41), P = 0.007), with increased severity compared to controls (U = 77(41), P < 0.001). Lower total NO bioactivity (U = 135(41), P = 0.049) and lower basal MCAv were apparent in players (F2,39 = 9.344, P = 0.004). This was accompanied by mild cognitive impairment (P = 0.020, 95% CI, −3.95 to −0.34), including impaired fine‐motor coordination (U = 141(41), P = 0.021). Retired rugby union players with history of multiple concussions may be characterised by impaired molecular, cerebral haemodynamic and cognitive function compared to non‐concussed, non‐contact controls.
SplitZNS: Towards an Efficient LSM-Tree on Zoned Namespace SSDs
Authors: Huang Dong , Feng Dan , Liu Qiankun , Ding Bo , Zhao Wei , Wei Xueliang , Tong Wei 
Published: July 2023

The Zoned Namespace (ZNS) Solid State Drive (SSD) is a nascent form of storage device that offers novel prospects for the Log Structured Merge Tree (LSM-tree). ZNS exposes erase blocks in SSD as append-only zones, enabling the LSM-tree to gain awareness of the physical layout of data. Nevertheless, LSM-tree on ZNS SSDs necessitates Garbage Collection (GC) owing to the mismatch between the gigantic zones and relatively small Sorted String Tables (SSTables). Through extensive experiments, we observe that a smaller zone size can reduce data migration in GC at the cost of a significant performance decline owing to inadequate parallelism exploitation. In this article, we present SplitZNS, which introduces small zones by tweaking the zone-to-chip mapping to maximize GC efficiency for LSM-tree on ZNS SSDs. Following the multi-level peculiarity of LSM-tree and the inherent parallel architecture of ZNS SSDs, we propose a number of techniques to leverage and accelerate small zones to alleviate the performance impact due to underutilized parallelism. (1) First, we use small zones selectively to prevent exacerbating write slowdowns and stalls due to their suboptimal performance. (2) Second, to enhance parallelism utilization, we propose SubZone Ring, which employs a per-chip FIFO buffer to imitate a large zone writing style; (3) Read Prefetcher, which prefetches data concurrently through multiple chips during compactions; (4) and Read Scheduler, which assigns query requests the highest priority. We build a prototype integrated with SplitZNS to validate its efficiency and efficacy. Experimental results demonstrate that SplitZNS achieves up to 2.77× performance and reduces data migration considerably compared to the lifetime-based data placement.

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A New Meta-Analysis of the Proteus Effect: Studies in VR Find Stronger Effect Sizes
Authors: Beyea David , Ratan Rabindra (Robby) , Lei Yiming (Skylar) , Liu Hanjie , Hales Gabriel E. , Lim Chaeyun 
Published: July 2023

Abstract
The present study examines why some studies of the Proteus effect—the phenomenon that people tend to conform behaviorally and attitudinally to their avatars’ identity characteristics—facilitate the phenomenon more effectively than others. A previous meta-analysis of the Proteus effect (Ratan et al., 2020) failed to examine potentially notable moderating factors of the phenomenon, so we examine such factors through a meta-analysis of the 56 quantitative experimental Proteus effect studies published at the time of this analysis. Studies that utilized virtual reality technology (e.g., head-mounted displays) elicited stronger effect sizes than those that utilized flat screens, as hypothesized. No support was found for the hypothesis that effect sizes differ by software type utilized (commercial or custom-built). We offer suggestions for future research into the Proteus effect, and how to best examine possible variables of the phenomenon.
A Longitudinal Study of the Impact of a Suicide Bereavement Service on People Bereaved by Suicide
Authors: Visser Victoria , Tretheway Rebecca 
Published: July 2023

Whilst the body of research on the impacts of suicide bereavement interventions continues to grow, there is little understanding of the impact over time. This study measured changes in suicidality, levels of loneliness and grief reactions over time between those receiving support from a community-based suicide bereavement service (StandBy) compared with those that did not receive this support. Data were collected through an online survey with participation at baseline being varying times post loss, and three-months post-baseline (StandBy n = 174, Comparison n = 322). Statistical analysis included linear mixed-effects modelling for repeated measures. Results were consistent with earlier studies showing the positive impact of StandBy on participants’ grief responses, loneliness and suicidality, specifically within the first 12 months after their loss. However, these outcomes were not retained over time, with the exception of suicidality. Further longitudinal studies consisting of more than two time-points and a greater period between time-points is warranted.
Exercise therapy including the cervical extensor muscles in individuals with neck pain: A systematic review
Authors: Colman David , Demoulin Christophe , Vanderthommen Marc , Saive Olivier , Durieux Nancy , Cagnie Barbara , Kaux Jean-François , Grosdent Stéphanie 
Published: July 2023

Objective To review the use (dosage parameters and combination with other therapeutic interventions) of cervical extensor muscle exercises and their effect on pain, disability (primary outcomes), range of motion, endurance and strength (secondary outcomes) in people with neck pain. Data sources An extensive literature search was conducted through MEDLINE (Ovid), Scopus (Elsevier) and Physiotherapy Evidence Database (PEDro) up to May 2023. The reference lists of all included studies and relevant reviews were screened for additional studies. Review methods Randomised controlled trials reporting the use of cervical extensor muscle exercises (alone or combined) applied to adults with idiopathic or traumatic neck pain were included. Study selection, data extraction and critical appraisal (PEDro assessment scale) were performed by two blinded reviewers. Data extraction included dosage parameters, other modalities combined with these exercises and outcomes. Results Thirty-five randomised controlled trails (eight of which were complementary analyses) with 2409 participants fulfilled the inclusion criteria. Twenty-six were of moderate to high quality. In most studies, cervical extensor muscle exercises were combined with various other therapeutic modalities and applied at different dosages. Only two studies (one high and one low quality) specifically assessed their effectiveness. The high-quality study showed significant improvements in neck pain and disability, pressure point threshold and neck mobility after both low load and high load training for 6 weeks. Conclusion The results suggest cervical extensor muscle exercises may reduce neck pain and disability; however firm conclusions cannot be drawn because of the few studies that addressed this question and the heterogeneity of the dosage parameters.
Transcaval Coil Embolization of Type 2 Endoleak After Endovascular Aortic Repair: An Institutional Review
Authors: Cheadle Gerald A. , Dwivedi Amit J. , Wayne Erik J. , Cheadle William G. , Sigdel Abindra 
Published: July 2023

Objectives Endovascular aortic repair may be complicated by type 2 endoleaks. Intervention is generally recommended when the native sac continues to grow more than 5 mm. Transcaval coil embolization (TCE) of the native aneurysm sac is an emerging technique for repair of type 2 endoleaks. The objective of this study is to report an institutional review of our experience with this technique. Methods 11 patients underwent TCE during the study period. Data were gathered on demographics, size increase of native aneurysm sac, operative details, and outcomes. Technical success was defined as resolution of the endoleak during completion sac angiogram at end of the procedure. Clinical success was defined as no growth in the aneurysm sac at interval follow-up. Results Coils were the embolant of choice in all cases. Technical success was achieved in all cases except 1 resulting in a 91% technical success rate. Median follow-up was 25 months (range, 3-33). Of the ten patients that had technically successful embolization, 8 patients had repeat computed tomography (CT) scans which showed no further expansion of the native sac resulting in a 80% clinical success rate. No complications were noted immediately post-op or at interval follow-up. Conclusions This institutional retrospective review demonstrates that TCE is an effective and safe option for type 2 endoleaks after endovascular aortic repair (EVAR) in selected patients with favorable anatomy. Longer term follow-up, more patients, and comparison studies are needed to further define durability and efficacy.