bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal distancing of crops reduces pest pressure while maintaining conservation biocontrol in oilseed rape
Authors: Sulg Silva , Kovács Gabriella , Willow Jonathan , Kaasik Riina , Smagghe Guy , Lövei Gabor L , Veromann Eve 
Published: January 2023

AbstractBACKGROUNDAgricultural landscapes provide resources for arthropod pests as well as their natural enemies. To develop integrated pest management (IPM) practices, it is important to understand how spatiotemporal location influences crop colonization and damage severity. We performed a 3‐year (2016–2018) field experiment in winter oilseed rape (OSR, Brassica napus) fields in Estonia, where half of the fields were within 500 m of the location of the previous year's winter OSR field and half were outside this zone. We investigated how distance from the previous year's OSR crop influences the infestation and parasitism rates of two of its most important pests: the pollen beetle (Brassicogethes aeneus) and the cabbage seed weevil (Ceutorhynchus obstrictus).RESULTSWhen the distance from the previous year's OSR crop was >500 m, we recorded significantly reduced pest pressure by both B. aeneus and C. obstrictus in the study fields. Biocontrol of both pests, provided by parasitic wasps, was high in each study year and commonly not affected by distance. Mean parasitism rates of B. aeneus were >31%, occasionally reaching >70%; for C. obstrictus, mean parasitism was >46%, reaching up to 79%, thereby providing effective biocontrol for both pest species.CONCLUSIONSpatiotemporal separation of OSR fields can reduce pest pressure without resulting in reduced parasitism of OSR pests. This supports a spatiotemporal field separation concept as an effective and sustainable technique for IPM in OSR. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Life‐table analyses for the tomato leaf miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae): effects of plant genotype
Authors: Guruswamy Megha , Marimuthu Murugan , Coll Moshe 
Published: January 2023

AbstractBACKGROUNDHost plant resistance plays an important role in integrated pest management programs. Crop resistance assessments commonly focus on only a single dependent variable, such as larval survival/plant damage, which limits the ability to appreciate the impact of host plants on pest populations in the full sense. Therefore, we performed life‐table analyses for tomato leaf miner Tuta absoluta, on 19 Solanum lycopersicum genotypes and a wild Solanum habrochaites accession. These analyses assess the ability of the pest to attain a high population density on different tomato genotypes. Based on the resulting ranking of tomato resistance at the vegetative stage (45‐day‐old plants), we tested the resistance of six selected genotypes at the reproductive stage (4‐month‐old plants).RESULTST. absoluta performance was significantly inferior on vegetative‐stage S. habrochaites plants (LA 1777); time taken for the first instars to mine the leaves (5 ± 0.14 days), development time of early‐ and late‐stage larvae (8.8 ± 0.2 and 4.2 ± 0.2 days, respectively), pupal period (11.2 ± 0.58 days), and total developmental time (29.4 ± 0.83 days) were significantly longer, fecundity was significantly lower (18.66 ± 7.24 days), and the highest total mortality (63.33%) also recorded compared with other genotypes, resulting in the lowest net reproductive rate (R0) (11.20 ± 2.51). For the six selected genotypes, the ranking of plant resistance did not change between plants at the vegetative and reproductive stages.CONCLUSIONThis study suggested that of 20 screened tomato genotypes, LA 1777 and EC‐620343 are the least suitable hosts for T. absoluta to establish fast‐growing populations, and thus can be employed in integrated T. absoluta management. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Depression during the COVID‐19 pandemic among people living with HIV: Are low HIV/AIDS stigma and high perceived emotional support protective resources?
Authors: Rzeszutek Marcin , Gruszczyńska Ewa 
Published: January 2023

AbstractThis study has two objectives: first, to examine changes in depressive symptoms among people living with HIV (PLWH) during the COVID‐19 pandemic and, second, to verify the role of HIV/AIDS stigma and perceived emotional support (PES) in the heterogeneity of these changes. The participants were 392 people with a medical diagnosis of HIV who have undergone antiretroviral therapy. Depression was measured at three time points with 6‐month intervals using the Centre for Epidemiological Studies Depression Scale (CES‐D). PES was evaluated with the Berlin Social Support Scales, and HIV/AIDS‐related stigma was assessed with the Berger HIV Stigma Scale. Latent growth class modelling identified four trajectories of depression over the study period: three stable (very high, high, and very low) and one increasing. Both the very high and high stable trajectories had baseline values above the CES‐D cut‐off point for depression, suggesting that 57.6% of the sample was likely to be diagnosed with depression. After controlling for sociodemographic and clinical variables, stigma and PES were found to be significant covariates of the obtained trajectories; however, they did not protect against an increase in depression symptoms. There was no overall increase in depression symptoms among the PLWH participants during the pandemic, but this change in depression symptoms was heterogeneous. We observed the potential development of depression in initially well‐functioning individuals despite their personal resources differing only slightly from those who remained resilient.
Low‐Dose NIR‐II Preclinical Bioimaging Using Liposome‐Encapsulated Cyanine Dyes
Authors: Gao Duyang , Luo Zichao , He Yang , Yang Lixiang , Hu Dehong , Liang Yongye , Zheng Hairong , Liu Xiaogang , Sheng Zonghai 
Published: January 2023

AbstractFluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) provides a powerful tool for in vivo structural and functional imaging in deep tissue. However, the lack of biocompatible contrast agents with bright NIR‐II emission has hindered its application in fundamental research and clinical trials. Herein, a liposome encapsulation strategy for generating ultrabright liposome‐cyanine dyes by restricting dyes in the hydrophobic pockets of lipids and inhibiting the aggregation, as corroborated by computational modeling, is reported. Compared with free indocyanine green (ICG, an US Food and Drug Administration‐approved cyanine dye), liposome‐encapsulated ICG (S‐Lipo‐ICG) shows a 38.7‐fold increase in NIR‐II brightness and enables cerebrovascular imaging at only one‐tenth dose over a long period (30 min). By adjusting the excitation wavelength, two liposome‐encapsulated cyanine dyes (S‐Lipo‐ICG and S‐Lipo‐FD1080) enable NIR‐II dual‐color imaging. Moreover, small tumor nodules (2–5 mm) can be successfully distinguished and removed with S‐Lipo‐ICG image‐guided tumor surgery in rabbit models. This liposome encapsulation maintains the metabolic pathway of ICG, promising for clinical implementation.
Lateral Heterostructures of Graphene and h‐BN with Atomic Lattice Coherence and Tunable Rotational Order
Authors: Guo Haojie , Garro‐Hernandorena Ane , Martínez‐Galera Antonio J. , Gómez‐Rodríguez José M. 
Published: January 2023

AbstractIn‐plane heterostructures of graphene and hexagonal boron nitride (h‐BN) exhibit exceptional properties, which are highly sensitive to the structure of the alternating domains. Nevertheless, achieving accurate control over their structural properties, while keeping a high perfection at the graphene‐h‐BN boundaries, still remains a challenge. Here, the growth of lateral heterostructures of graphene and h‐BN on Rh(110) surfaces is reported. The choice of the 2D material, grown firstly, determines the structural properties of the whole heterostructure layer, allowing to have control over the rotational order of the domains. The atomic‐scale observation of the boundaries demonstrates a perfect lateral matching. In‐plane heterostructures floating over an oxygen layer have been successfully obtained, enabling to observe intervalley scattering processes in graphene regions. The high tuning capabilities of these heterostructures, along with their good structural quality, even around the boundaries, suggest their usage as test beds for fundamental studies aiming at the development of novel nanomaterials with tailored properties.
Embedding Plasmonic Metal into Heterointerface of MOFs‐Encapsulated Semiconductor Hollow Architecture for Boosting CO2 Photoreduction
Authors: Mo Weihao , Fan Zhixin , Zhong Shuxian , Chen Wenbin , Hu Lingxuan , Zhou Hao , Zhao Wei , Lin Hongjun , Ge Jing , Chen Jianrong , Bai Song 
Published: January 2023

AbstractCoupling hollow semiconductor with metal–organic frameworks (MOFs) holds great promise for constructing high‐efficient CO2 photoreduction systems. However, energy band mismatch between them makes it difficult to exert their advantages to maximize the overall photocatalytic efficiency, since that the blockage of desirable interfacial charge transfer gives rise to the enrichment of photoelectrons and CO2 molecules on the different locations. Herein, an interfacial engineering is presented to overcome this impediment, based on the insertion of plasmonic metal into the heterointerfaces between them, forming a stacked semiconductor/metal@MOF photocatalyst. Experimental observations and theoretical simulations validate the critical roles of embedded Au in maneuvering the charge separation/transfer and surface reaction: (i) bridges the photoelectron transfer from hollow CdS (H‐CdS) to ZIF‐8; (ii) produces hot electrons and shifts them to ZIF‐8; (iii) induces the formation of ZIF‐8 defects in promoting the CO2 adsorption/activation and transformation to CO with low energy barriers. Consequently, the as‐prepared H‐CdS/Au@ZIF‐8 with optimal ZIF‐8 thickness exhibits distinctly boosted activity and superb selectivity in CO production as compared with H‐CdS@ZIF‐8 and other counterparts. This work provides protocols to take full advantages of components involved for enhanced solar‐to‐chemical energy conversion efficiency of hybrid artificial photosynthetic systems through rationally harnessing the charge transfer between them.
Impact of Starch Gelatinization on Digestibility and Human Health
Authors: Qi Xin , Tester Richard 
Published: January 2023

AbstractThe availability of digestible energy from consumed starch depends on whether the starch is in an amorphous/digestible or ordered/less digestible form. The capacity of man to digest starch has been an evolutionary process where early hunter gatherers would have eaten crops with relatively low amounts of starch that is also not cooked. This requires a lot of digestive effort to extract calories and hence the efficiency in the body of the starch digestive process. Modern man, however, cooks (and has done for centuries) starchy crops. This, combined with the high starch contents of foods that are also readily available, has led to excess calories in the diet (from other nutrient sources too) and associated disease states. This article is designed to set the gelatinization of starch in the context of health and how starch processing needs to be regulated to control excess calories in the diet – many from starch. Key messages to gain from this review are that i) starch is a potential source of energy and depending on how and when it is processed and consumed it will impact on energy and health plus that ii) overall management of calories – including from digestible starch – is critical for optimal health.
Decision tree for local + global imperfection combinations in double‐symmetric prismatic members – Practical recommendations in the framework of advanced analysis
Authors: Müller Andreas , Vild Martin , Taras Andreas 
Published: January 2023

AbstractBetter and simpler possibilities of structural optimization due to increasing computational power but also for reasons of environmental sustainability, the use of materials and their reusability lead to greater acceptance towards more advanced numerically intensive, so‐called ‘design by analysis' methods like geometrically and materially non‐linear analyses with imperfections (GMNIA). The general choice of imperfections and their combination in such models, especially for slender cross sections of intermediate length prone to an interaction between a global and local plate buckling, is crucial in terms of the reached load‐bearing capacity. Annex C of EN 1993‐1‐5:2010 makes use of the ‘70 %‐rule' for the combination of imperfection modes and amplitudes. This rule postulates that two GMNIA calculations should be conducted when local and global interactive buckling may be dominant; one with 100 % + 70 % of the maximum specified amplitude in either case. In addition, extended information is provided on the choice and combination of imperfections in the newly introduced and currently available draft of the prEN 1993‐1‐14:2020 (design assisted by finite element analysis). Although information is provided on how the local and global imperfections should be combined, it is not stated when it is relevant to consider those. Based on conducted GMNIA simulations on SHS/RHS (square and rectangular hollow sections) and I‐shaped sections, this article presents general decision support on the choice of equivalent imperfections. On the basis of numerical analysis, the developed flow chart and design routine allow for the decision whether the consideration of the interaction of local and global imperfections is required or not.
RBM15 silencing promotes ferroptosis by regulating the TGF‐β/Smad2 pathway in lung cancer
Authors: Feng Jing , Li Yaling , He Fen , Zhang Fuwei 
Published: January 2023

AbstractObjectiveWe assessed the function and mechanism of RNA binding motif protein 15 (RBM15) silencing in lung cancer development.MethodsThe effects of RBM15 knockdown on A549 and H1299 cells were evaluated by MTT, EdU, wound healing, and transwell assay. We then detected the functions of RBM15 silencing on lipid peroxidation, labile iron pool (LIP), ferrous iron (Fe2+), and ferroptosis‐related genes. RNA sequencing was performed after RBM15 knockout in lung cancer cells, followed by differentially expressed genes (DEGs), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed. Finally, the expression of RBM15 and pathway‐related genes was determined by western blot.ResultsRBM15 was highly expressed in lung cancer cells. RBM15 silencing reduced the viability, inhibited cell proliferation, invasion, and migration, and suppressed tumor growth in the xenograft mouse model. Knockout of RBM15 regulated ferroptosis‐related gene expression. LIP, Fe2+, and lipid peroxidation were distinctly increased by the knockout of RBM15. RNA‐seq sequencing revealed that there are 367 up‐regulated and 368 down‐regulated DEGs, which were enriched in molecular functions, biological processes, and cellular components. RBM15 silencing reduced the expression of TGF‐β/Smad2, and TGF‐β activator (SRI‐011381) reversed the inhibitory effect of RBM15 silencing on tumor cell growth.ConclusionWe demonstrated that RBM15 silencing promoted ferroptosis in lung cancer cells by TGF‐β/Smad2 pathway, thereby inhibiting lung cancer cell growth, which may provide new light for lung cancer treatment.
Nrf2 and NF‐қB interplay in tamoxifen‐induced hepatic toxicity: A promising therapeutic approach of sildenafil and low‐dose γ radiation
Authors: Karam Heba M. , Galal Shereen M. , Lotfy Dina M. 
Published: January 2023

AbstractTamoxifen‐induced hepatotoxicity is an inevitable side effect during breast cancer treatment. Low‐dose gamma irradiation (IRR) shows many beneficial effects by stimulating various biological processes. This study evaluates the possible effect of sildenafil and low‐dose gamma radiation on liver damages as new treatment strategies. Group I (control), group II: (tamoxifen), group III: (tamoxifen + Sildenafil), group IV: (tamoxifen+ irradiation) and group V: (tamoxifen +Sildenafil + irradiation). Rats were sacrificed after 5 h from tamoxifen injection. Results showed that tamoxifen caused elevation in serum AST, ALT and ALP as well hepatic ROS, iNOS, MDA, Keap‐1 and NF‐Kb, in addition to diminution in hepatic Nrf2 and HO‐1. Exposure to low‐dose gamma radiation and sildenafil amended the alterations in the measured parameters in serum and tissue. Moreover, all results were confirmed by histopathological examination. In conclusion, sildenafil and low‐dose gamma radiation can mitigate the toxicity induced by tamoxifen in liver tissues. Hence, this treatment could be further evaluated as a new approach for alleviating various liver disorders.
Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR‐625‐5p axis
Authors: Mo Zhaohong , Li Ruixi , Cao Chuanlin , Li Yanjie , Zheng Shiyang , Wu Runxin , Xue Jinhua , Hu Jingxiong , Meng Hongyu , Zhai Hang , Huang Weiling , Zheng Fang , Zhou Boxuan 
Published: January 2023

AbstractMicrovascular invasion (MVI) is a crucial risk factor related to the metastasis of hepatocellular carcinoma (HCC), but the underlying mechanisms remain to be revealed. Characterizing the inherent mechanisms of MVI may aid in the development of effective treatment strategies to improve the prognosis of HCC patients with metastasis. Through the Gene Expression Omnibus (GEO) database, we identified that small nuclear ribonucleoprotein polypeptide A (SNRPA) was related to MVI in HCC. SNRPA was overexpressed in MVI‐HCC and correlated with poor patient survival. Mechanistically, SNRPA promoted the epithelial‐mesenchymal transition (EMT)‐like process for HCC cells to accelerate metastasis by activating the NOTCH1/Snail pathway in vitro and in vivo. Importantly, circSEC62 upregulated SNRPA expression in HCC cells via miR‐625‐5p sponging. Taking these results together, our study identified a novel regulatory mechanism among SNRPA, miR‐625‐5p, circSEC62 and the NOTCH1/Snail pathway in HCC, which promoted metastasis of HCC and may provide effective suggestions for improving the prognosis of HCC patients with metastasis.
Echocardiographic changes in the progress of reverse shunt and improvement to left‐to‐right shunt after medical treatment in dogs with bidirectional patent ductus arteriosus or ventricular septal defect: A report of two cases
Authors: Kim Yein , Kwon Danbee , Kim Sung‐Soo , Lee Kichang , Yoon Hakyoung 
Published: January 2023

AbstractTwo Maltese dogs were referred for evaluation of a congenital heart disease: one was diagnosed with patent ductus arteriosus and the other was diagnosed with a ventricular septal defect. The PDA patient was diagnosed with congenital heart disease 2 weeks ago and the VSD patient about 11 months ago at another hospital. Echocardiographic findings revealed a bidirectional shunt condition, and the dogs were treated with medical management using sildenafil and oxygen inhalation. After medical management, the dogs returned to clinically normal conditions, and echocardiographic findings revealed a return to left‐to‐right shunt tendency. These dogs had no clinical signs associated with heart disease 3 years after treatment. This case report describes changes in echocardiography findings according to the progression of the reverse shunt and the possibility of improvement to a left‐to‐right shunt after medical treatment.
Transient solute dispersion in electro‐osmotic viscoplastic flow in a microchannel
Authors: Roy Ashis Kumar , Debnath Sudip , Bég O. Anwar 
Published: January 2023

AbstractThe transport of a neutral solute in incompressible electro‐osmotic flow of Bingham plastic non‐Newtonian liquid flowing through a microchannel is studied theoretically. The flow is driven by a constant axially applied electric field. The non‐dimensional conservation equations with associated boundary conditions are solved with Gill's series expansion technique. The whole transport process is analyzed using three transport coefficients, namely, advection coefficient, dispersion coefficient and the apparent asymmetry coefficient, respectively. The mean concentration distribution of the solute is calculated via a third‐order approximation of the series expansion. The study investigates the collective effects of yield stress and electric double layer (EDL) thickness (inverse Debye length) on the transport of solute. The long‐term behaviour of mean concentration distribution is shown to be accurately predicted by second‐order approximations; however, utilizing third or higher order approximations in Gill's series expansion enables a more refined analysis of the small and moderate time behavior of transport coefficients. The present analysis is relevant to emerging applications in bio‐microfluidics exploiting electroviscous fluent media.
Assessment of non‐polynomial shear deformation theories for the free vibration and transient analysis of plates with functionally‐graded materials supported on an elastic foundation
Authors: Chanda Aniket Gopa , Kontoni Denise‐Penelope N. , Kumar Haldar Amit , Guan Zhongwei 
Published: January 2023

AbstractIn this article, various non‐polynomial higher‐order shear deformation theories are applied for the first time to analyze the free vibration and transient responses of plates with functionally graded material (FGM) supported on an elastic foundation. The shear deformation theories account for the non‐linear variation of the transverse shear strains with various warping functions, namely trigonometric, inverse hyperbolic, and inverse trigonometric ones. These models also inherently satisfy the traction‐free boundary conditions of transverse shear stresses at the top and bottom surfaces of the plates and do not require any shear correction factor. A two‐parameter model, namely Winkler‐Pasternak's elastic foundation model, is utilized to develop the interaction between the FGM plates and the elastic medium. The governing equations of motion are obtained using Hamilton's principle and solved analytically using Navier's solution scheme. Furthermore, the transient responses of the plates are obtained using Newmark's average acceleration method. The applicability of the present theories is established by solving several numerical problems and validating the results with the solutions available in the literature. The effects of various parameters like span‐thickness ratios, aspect ratios, gradation coefficients, mechanical loads, and foundation stiffness on the fundamental frequencies and the transient responses of the plates are thoroughly investigated. The comparison of the results reveals the efficiency of the non‐polynomial functions, and the capability of efficient prediction of the structural responses of the FGM plates at a similar computational cost compared to established models in the literature. Furthermore, the results show that the stiffness of the elastic foundation can tweak the stiffness characteristics of the FGM plate resulting in significant changes in the natural frequencies and more controlled displacement‐time responses.