bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vancomycin Flushing Syndrome After the Use of Vancomycin-Impregnated Bone Graft During Spine Surgery
Authors: Iyer R. Dinesh , Shetty Ajoy Prasad , Kanna Rishi Mugesh , Sri Vijay Anand K. S. , Shanmuganathan Rajasekaran 
Published: August 2023

Case:
Intrawound vancomycin in spine surgery is a common clinical practice. We report a case of a 14-year-old adolescent girl undergoing surgery for scoliosis correction who developed features of vancomycin flushing syndrome after the use of vancomycin-impregnated bone graft. After resuscitation, she was extubated and had an uneventful postoperative recovery. At 1-year follow-up, she is back to her routine without any sequelae of the intraoperative event.

Conclusion:
The use of intrawound vancomycin can result in life-threatening reactions. With the increase in its use, the anesthetist and the surgeon must be aware of such complications.
Investigation of rock mass deformation through nap-of-the-object photogrammetry: a case study of Hongyun Golden Peak in Fanjing Mountain, China
Authors: Dang Jie , Fan Xuanmei , Wang Xin , Li Zhenglin , Leng Yangyang 
Published: August 2023

Abstract

Traditional field investigation methods are inapplicable in some landslide cases where numerous dangerous rocks are distributed. Therefore, nap-of-the-object photogrammetry (NOOP) has been developed for such applications while meeting the demand for fine measurements. The new technology involves using UAVs to fly close to the object surface to obtain subcentimeter high-resolution images. Afterward, software is used to achieve a fine surface model of the target object. In this paper, a case study of the deformation characteristics of the high-steep rock mass of Hongyun Golden Peak of Fanjing Mountain in Guizhou Province, China, is conducted. Through preliminary oblique photogrammetry, which involves data processing, NOOP route planning, and fine NOOP, a realistic 3D surface model of the Golden Peak of Fanjing Mountain is obtained. The resolution of the model could reach the millimeter level (2 mm). Detailed characteristics of the 3 groups of joints and 9 deep-large cracks are obtained from the rock structure investigation and statistical analysis of fissure deformation. NOOP can be used to acquire the elevation of the target object, thus compensating for the deficiencies of oblique photogrammetry. Additionally, it accurately reproduces the terrain and fine object structures. The results of this study can provide a reference for geological investigations involving monitoring high-steepness dangerous rocks.
Laser Hemorrhoidoplasty vs Rubber Band Ligation: A randomized trial comparing 2 mini-invasive treatment for grade II hemorrhoids
Authors: Jin# Lei , Qin Kaijian , Wu Renjie , Yang Haojie , Cui Can , Wang Zhenyi , Wu Jiong 
Published: August 2023

Abstract

Purpose
As a minimally invasive procedure, laser hemorrhoidoplasty (LHP) can not only relieve the symptoms of hemorrhoids, but also protect the anal cushion structure. This study aimed to investigate the clinical efficacy of LHP in the treatment of grade II hemorrhoids.
Methods
A total of 70 patients with grade II hemorrhoids were randomly assigned to receive LHP or Rubber Band Ligation (RBL) (n = 35 per group) in 2019 from a single center. The postoperative pain, bleeding, feeling of anal distension and postoperative recurrence rate were compared between the two groups.
Results
The postoperative pain, bleeding, and feeling of anal distension in the LHP group were improved significantly as compared with the RBL group within 2 weeks after surgery (P < 0.01). Both methods can relieve the symptoms of grade II hemorrhoids. There was no difference in the recurrence rate between the two groups at 1 year after surgery (P > 0.05). The patients in LHP group took less time to return to normal activities (P < 0.001).
Conclusions
As a minimally invasive treatment, LHP is easy and not traumatic and results in mild postoperative pain and few complications. It is an ideal choice for grade II hemorrhoids.
Assessment of the Covid-19 impact on the Brazilian Unified Health System (SUS) financing: an analysis of the financing dynamics of 2020 and 2021
Authors: Corrêa Ana Carolina Costa , Rigotti Maria Luisa Oliveira , Lacerda Hugo Dillhermando de Souza , Ferreira Bruno Pérez 
Published: August 2023

Abstract

Background
After the establishment of the public health emergency of international concern in 2020, health systems worldwide and in Brazil observed the need to apply more extraordinary logistical efforts and possibly resources to combat the imminent pandemic.
Methods
Using the historical series of public expenditures of the National Health Fund (FNS), 2015 to 2021, the number of confirmed cases of Covid-19, and a seasonal ARIMAX model, we sought to assess how the increase in the new virus infections affected the systematic financing of the Unified Health System (SUS) in Brazil.
Results
There were signs of seasonality and an increasing trend in the expenditure variable, which in practical terms, only indicated that the resource contributions followed an increasing trajectory already underway before the advent of the pandemic. The 1% increase in Covid-19 cases, with a one-month lag, contributes to the 0.062% increase in the variation in FNS expenditures but a decrease of 0.058% with a two-month lag.
Conclusion
The tests showed no evidence to confirm a positive shift on FNS spending growth trajectory due to the increase of Covid-19 cases, only observing a significant increase one month after the occurrence of Covid cases, probably due to their worsening after this period, which was followed by a similar and comparable decrease in percentage of growth in the following month.
Applying i-PARIHS to Identify Emerging Innovations in Hospital Discharge Decision Making in Response to System Stress: A Qualitative Study
Authors: Gustavson Allison M. , Miller Matthew J. , Boening Natassia , Wisdom Jennifer P. , Burke Robert E. , Hagedorn Hildi J. 
Published: August 2023

Abstract

Background
The purpose of this qualitative study was to use a Learning Health System approach to identify factors influencing the emergence of innovation in rehabilitation hospital discharge decision-making during the Coronavirus 2019 (COVID-19) pandemic.
Methods
Rehabilitation clinicians were recruited from the Veterans Affairs Health Care System and participated in individual semi-structured interviews guided by the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework. Data were analyzed using a rapid qualitative, deductive team-based approach informed by directed content analysis.
Results
Twenty-three rehabilitation clinicians representing physical (N = 11) and occupational therapy (N = 12) participated in the study. Three primary themes were generated: (1) Recipients: innovations emerged as approaches to communicating discharge recommendations changed (in-person to virtual) and strong patient/family preferences to discharge to the home challenged collaborative goal setting; (2) Context: the ability of rehabilitation clinicians to innovate and the form of innovations were influenced by the broader hospital system, interdisciplinary team dynamics, and policy fluctuations; (3) Innovation: emerging innovations in discharge processes included perceived increases in team collaboration, shifts in caseload prioritization, and alternative options for post-acute care.
Conclusions
Our findings reinforce that rehabilitation clinicians developed innovative strategies to quickly adapt to multiple systems-level factors that were changing in the face of the COVID-19 pandemic. Future research is needed to assess the impact of innovations, remediate unintended consequences, and evaluate the implementation of promising innovations to respond to emerging healthcare delivery needs more rapidly.
Research interests and emerging trends of meniscal extrusion and the future of arthroscopic centralization: a bibliometric and visualized analysis in the last 20 years
Authors: Chen Qi , He Chunrong , He Jinshen 
Published: August 2023

Abstract

Background: Bibliometrics refers to measuring the scientific output of an author, institution, or country. Visualized analysis transforms data into visible form by software, allowing researchers to gain knowledge of significant aspects of their data easily and quickly. This study conducts a comprehensive bibliometric analysis of the literature on meniscal extrusion and arthroscopic centralization, while also incorporating trend visualization for enhanced insights.Methods:Web of Science (WOS) was chosen as the database for this evaluation. The search encompassed the period from January 1, 2002, to December 31, 2022, yielding 690 records after exclusion. The publications, citations, authors, keywords, countries, and institutions were subjected to analysis using VOSviewer and Citespace.Results:The number of publications progressively increases year by year. The United States and Japan emerge as the top two countries, with Boston University and Okayama University being the leading institutes. Guermazi Ali and Furumatsu Takayuki are the top two authors with the most publications. Among the journals,Knee surgery, sports traumatology, arthroscopy,Osteoarthritis and Cartilageexhibit the most substantial number of publications. Notably, there has been a recent focus on pullout repair, posterior root tear, meniscal extrusion, and meniscus centralization, attracting significant attention in the field.Conclusion:The results reveal that research related to meniscal extrusion and arthroscopic centralization predominantly originates from a limited number of corresponding authors and institutions. There is a strong interest in this topic within top-tier sports medicine journals and among developed countries. The focus of interest in this field has undergone dynamic shifts over time.
Research on Influencing Factors of scenic spot passenger flow based on big data
Authors: Li Man 
Published: August 2023

Abstract
In 2021, driven by factors such as the continued loose fiscal and monetary policies of major economies and the acceleration of global vaccine production and vaccination, global tourism economic activities will show a clear recovery trend. As vaccination rates continue to rise and restrictions on international travel are eased around the world, the global tourism industry is continuing to grow and recover steadily. The paper first analyzes and summarizes the changing trend of tourism under the epidemic situation, and further expounds the related academic research on tourism development. Taking the Baidu Index as a measure of network attention, the Baidu Index data of national tourist attractions from April 15 to October 15, 2021 was collected to analyze the network attention of scenic spots from the perspective of time and space, combined with the unique characteristics of Hangzhou. Based on the characteristics of location and tourism resources, the factors affecting the tourist flow of scenic spots and the relationship between them were analyzed by SPSS statistical method.
The Relationship between Defensive pessimism, Goal Orientation and Self Esteem among Faculty Nursing Students
Authors: hussein mohamed , Rushdan Esraa , elzohairy nadia 
Published: August 2023

Abstract
Background: The academic achievement of students is closely tied to their self-worth and ability to stay focused on their goals. Furthermore, students can use their cognitive abilities to pursue their goal direction and motivate themselves. They may set low expectations before entering a situation, not because they believe they will fail, but to prepare themselves for the possibility of failure. By doing so, they can motivate themselves to work harder and avoid anticipated failure, which is known as defensive pessimism.
The study’s aims: Assess the levels of defensive pessimism, goal orientation, and self-esteem of nursing students at the Faculty of Nursing, Alexandria University.
Subjects: 400 students were included in research by stratified sampling method followed by simple randomization sampling technique to select 100 students from each academic year.
Tools: The Defensive Pessimism Questionnaire, The Goal Orientation Scale, and Self-Esteem Scale were used.
Results: 56.28% of participants had a low level of defensive pessimism, about two thirds (62.30%) of the participants had a low level of goal orientation, and 70.0% of the students had a mild level of self-esteem.
Conclusion: It was observed that there is a significant and positive correlation between defensive pessimism and goal orientation while there was a negative significant correlation found with self-esteem.
Implications: it is suggested that workshops be conducted for nursing students to educate them about defensive pessimism, goal orientation, and self-esteem. This will help the students to understand these concepts better and develop psycho-education program to improve their goal-setting abilities, self-esteem, and decrease use of defensive pessimism which may lead to better academic achievement.
Effects of local mutations in quadratic iterations
Authors: Radulescu Anca Ruxandra , Longbotham Abraham , Collier Ashelee 
Published: August 2023

Abstract
We introduce mutations in replication systems in which the intact copying mechanism is performed by discrete iterations of a complex quadratic map in the family fc(z) = z2 + c. More specifically, we consider a “correct” function fc1 acting on the complex plane (representing the DNA to be copied). A “mutation” fc0 is a different (“erroneous”) map acting on a locus of given radius r around a mutation focal point ξ∗. The effect of the mutation is interpolated radially to eventually recover the original map fc1 when reaching an outer radius R. We call the resulting map a “mutated” map.
In the theoretical framework of mutated iterations, we study how a mutation (replication error) affects the temporal evolution of the system, in the context of cell differentiation and tumor formation. We use the prisoner set of the system to quantify simultaneously the long-term behavior of the entire space under mutated maps. We analyze how the position, timing and size of the mutation can alter the system's long-term evolution (as encoded in the topology of its prisoner set), its progression into disease and its ability to recover or heal. In the context of genetics, mutated iterations may shed some light on aspects such as the importance of location, size and type of mutation when evaluating a system’s prognosis, and suggest ways to customize intervention.
rAj-Tspin, a novel peptide from Apostichopus japonicus, exerts anti-hepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway
Authors: Che Ying , Lu Xiaolong , Wang Xueting , Liu Zhien , Guan Liyang , Li Xin , Du Zaixing , Ren Hang , Wang Jihong , Zhou Zunchun , Lv Li 
Published: August 2023

Abstract

rAj-Tspin, a soluble gene recombinant peptide from Apostichopus japonicus, can inhibit the integrin β1 (ITGB1)/FAK/AKT signaling pathway in hepatocellular carcinoma (HCC) via cell epithelial–mesenchymal transition (EMT) and apoptosis. Zyxin (ZYX) is a focal adhesion protein that is considered a novel mediator of EMT and apoptosis. However, the inhibitory mechanisms of rAj-Tspin in HCC and whether it is related to ZYX are unclear. We examined the antitumor effect of rAj-Tspin on the Huh7 human HCC cell line and on nude mouse models with subcutaneous injection or orthotopic intrahepatic transplantation of Huh7 cells. Our results show that rAj-Tspin strikingly reduced cell viability and promoted apoptosis in Huh7 cells and inhibited HCC tumor growth in nude mice. rAj-Tspin dose-dependently inhibited ITGB1 and ZYX protein expression in vivo and in vitro. Mechanistically, the FAK/AKT signaling pathway and the proliferation and invasion of HCC cells were suppressed upon ITGB1 and ZYX knockdown. Moreover, the effect of ITGB1 overexpression on the growth of HCC cells could be inhibited by rAj-Tspin. In contrast, the promoting effect of ITGB1 overexpression could be inhibited by ZYX knockdown. ZYX knockdown had no effect on ITGB1 expression. These findings suggest that ZYX is required for the indispensable role of ITGB1 in rAj-Tspin-alleviated HCC and provide an important therapeutic target for HCC. In summary, the anti-HCC effect of rAj-Tspin potentially involves the regulation of the ITGB1/ZYX/FAK/AKT pathway, which in turn impacts EMT and apoptosis.
Bamboo Expansion Affects the Vertical Distribution and Phenotypic Plasticity of Root Systems of Native Cunninghamia lanceolata and Expanding Phyllostachys edulis in Middle-Southern China
Authors: Li Nan , Huang Wanwan , Zhou Cheng , Liu Yuping , He Shanshan , Li Jun , Ai Wensheng , Peng Chao 
Published: August 2023

Abstract

It is commonly known that bamboo shoots reduce native diversity by spreading through neighboring communities via their rhizome systems. However, the mechanism of root interaction between native species and expanding bamboo is poorly understood. This study aims to explore the differences in parameters such as biomass vertical distribution and phenotypic plasticity of root orders between expanding species, specifically moso bamboo (Phyllostachys edulis, Pe), and native species, Chinese fir (Cunninghamia lanceolate, Cl), at different expansion levels. The results show a heterogeneous reaction to expansion effects. The root biomass of Chinese fir significantly decreased from CLS to PCM, while bamboo root biomass exhibited a similar but insignificant decreasing trend from PES to CPM. Both root systems remained concentrated at the uppermost layers, where the FRB ratio of Pe was higher than Cl, and the majority of phenotypic traits of Pe root systems were noticeably higher than that of Cl in both vertical and horizontal soil. Additionally, the study found that soil factors explained root traits well, with a cumulative variation ranging from 53.87–88.48%. The findings suggest that bamboo expansion affects spatial heterogeneity and niche differentiation of both native and expanding species. In terms of root distribution and plastic reaction, Chinese fir is at a disadvantage compared to expanding bamboo, which worsens its survival conditions.
Attachment Styles and Quality of Romantic and Family Relationship in a French Population of Young Adults: the Mediating Role of Trait-mindfulness
Authors: CHAKROUN-BAGGIONI Nadia , SHANKLAND Rebecca , FALL Estelle 
Published: August 2023

Abstract

Although the literature has shown that attachment and mindfulness are related to relationship quality, their cumulative effect remains unclear. This study aims to understand the impact of mindfulness on the relationship between parental and adult attachment styles and the quality of relationships with parents and romantic partners in young adults. Data were collected on 195 first-year psychology students not experts in mindfulness. Structural equation models showed that trait mindfulness mediated the relationship between adult attachment and romantic relationship quality. Adult attachment had an indirect effect on the quality of romantic relationships. Mindfulness played an important mediating role as it was significantly associated with romantic relationships quality regardless of the nature of attachment. Only parental attachment was a predictor of quality of parental relationship. These results show that the more secure the attachment to the parents, the better the quality of the relationship with them in adulthood, while in romantic partners mindfulness plays a role in relationship quality. Therefore, interventions that develop trait mindfulness could be effective in increasing ability of young adults to have more satisfying relationships with their romantic partner. Interventions promoting the development of secure attachment would be the most suitable to improve quality of family relationships.
Disease suppression, growth promotion and colonization attributes of resident endophytic bacteria against white root rot (Dematophora necatrix Hartig) of apple
Authors: Pal Joginder , Sharma Satish K. , Sharma Anju 
Published: August 2023

Abstract

The inherent potential of apple trees was investigated to explore bacterial endophytes and their role in suppressingDematophora necatrix, the incitant of white root rot disease. Resultantly 34 endophytic bacteria secluded from healthy apple plants, and subsequently 6 most efficient isolates viz.Bacillus megateriumstrain EA3,Enterobactersp. strain EA7,Bacillus megateriumstrain EK2,Stenotrophomonas maltophiliastrain EK6,Acinetobacter nosocomialisstrain ES2 andPseudomonas aeruginosastrain ES8 depicting anti-pathogen interactions through preliminary screening were further assessed underin vitro, glasshouse and field conditions against white root rot disease. Maximum mycelial growth inhibition (80.37%) was obtained inS. maltophiliastrain EK6 encouraging for its seed treatment and soil application thereby providing significant effective control (87.91%) of white root rot under controlled culture situations as compared to other five bacterial endophytes evaluated simultaneously, followed by field efficacy of 83.70 per cent. In addition, it has significantly enhanced the growth parameters of apple trees under both the situations. The inoculated healthy plants were assessed for endophytic colonization which revealed maximum endosphere colonialism byS. maltophiliastrain EK6. Additionally, confocal microscopic explication of transverse sections of root cells colonized by bacterial endophytes as compared to untreated control implied their persistence and establishment in endosphere of apple seedlings. This investigation emphasized the first evidence of interaction between apple associated bacterial endophytes andD. necatrix, therefore these endophytes could be employed as alternative for mitigating white root rot disease in future.