bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Geological Implications of Lacustrine Carbonate of Nantun Formation in Hailar Basin
Authors: Lin Tong , Sha Zonglun , Zhu Kedan , Nan Jinhao , Ren Yanguang , Li Baoshuai 
Published: June 2023

Abstract
Globally, lacustrine carbonate rocks are often found in rift lake basins. Because they often do not form large-scale conventional or unconventional reservoirs, they have not received enough attention in previous oil and gas exploration. Recent years, exploration examples in China show that lacustrine carbonate has close relationship with unconventional oil and gas. Mudstone with carbonate deposits always has a good exploration effect in the area. However, the genesis of lacustrine carbonate is still controversial. The sediment environment difference between carbonate and mudstone and its effects on unconventional hydrocarbon accumulation are not yet clear. This paper focuses on lacustrine carbonate found in the Nantun Formation in Hailar Basin. Through the analysis of lithofacies, geochemistry, and logging data, several findings have been obtained in the current study. (a) Two kinds of lacustrine carbonates, micrite dolomite and marlstone, which represent semideep to deep lake environments, have been identified in the research area. (b) Lacustrine dolomite (LD), whose genesis may relate to magmatic movement and deep hydrothermal processes, shows an extremely dry, hot paleoclimate and a saline, anaerobic ancient water condition. (c) Carbonate deposition in mudstone is related to the condensation section, and marlstone and micrite dolomite represent the beginning and end of the condensation section, respectively. Compared with mudstone around carbonate rocks, LD represents a drier, hotter, and saltier environment, which is of significance for sedimentary environment identification. In addition, the mudstone with lacustrine carbonate deposits has better organic matter characteristics and can form good unconventional oil and gas reservoirs that are of great significance for further exploration.
Experimental Evaluation of Blends Containing Lineal Alkylbenzene Sulfonates for Surfactant Flooding in Carbonate Reservoirs
Authors: Somoza A. , Rodríguez-Cabo B. , Barrio I. , García-Mayoral M. F. , Soto A. 
Published: June 2023

Summary
About one-half of the proven conventional oil reserves are in carbonate reservoirs. However, conducting surfactant flooding in these reservoirs presents several challenges, including formation heterogeneities, surfactant retention, high temperature and salinity, and oil-wet/mixed-wet conditions. Linear alkylbenzene sulfonates (LASs) are low-cost anionic surfactants that tend to precipitate in high-salinity environments and show high adsorption values in carbonate material. In this paper, the possibility of using petrochemical LASs of different alkyl chain lengths and isomer content to extract oil from carbonate reservoirs was tested using blends with the ionic liquid cocosalkylpentaethoximethylammonium methylsulfate (C1EG). Phase behavior, stability in the presence of divalent ions, and interfacial tension (IFT) measurements were the criteria used to design several optimal formulations containing 36–45% LASs. The structure-performance relationship was further assessed via static adsorption and wettability tests. LASs enriched in isomers with the benzenesulfonic group in external positions of the alkyl chain resulted in lower IFT but significantly higher adsorption, so those surfactants were discarded for the application. Additional oil recoveries achieved with tested formulations ranged from 36.7% to 43.5% of the residual oil in place. The longer the alkyl chain length, the higher the oil recovery. The main mechanism associated with improved oil recovery is IFT reduction. The use of a cost-effective ionic liquid derived from natural raw materials, the stability of the blends, the low adsorption of the chemical, and a significant oil recovery ensure the overall feasibility of the proposal.
Automated Exploration of Economical and Safe Well Trajectories in Brown Oil and Gas Fields
Authors: Pathan Rizwan , Singh Umesh , Joshi Amol Dilip , Cavé Adrien , Fouchard Cédric , Baume Antonin 
Published: June 2023

Summary
Due to volatile and uncertain oil and gas prices, the need to reduce well planning and drilling cost is a crucial concern in the oil and gas exploration and production industry. Therefore, the focus has increased on brownfield sites for new oil and gas explorations. However, the presence of previously drilled wellbores, also known as legacy wells, in brownfield sites increases the risk of collision incidents during the drilling process. Thus, avoiding collisions is also an important objective in the well trajectory design process. Moreover, designing well trajectories is a challenging and time-consuming process. Such designs demand multiple interdependent iterations to arrive at a required cost-effective solution that meets the drillability and safety requirements. In this study, we developed a novel framework to automate the well trajectory design process, including a well trajectory optimization technique to generate safer and more economical well trajectories. The developed framework was tested on two live oil- and gasfield cases. The first field case involved designing a single well trajectory in a crowded field, and the second field case involved designing 36 well trajectories in a field that consists of 13 legacy wells. The developed framework has a high impact on reducing the well trajectory design time and drilling length of trajectories. For example, in the second field case study, the obtained solution resulted in total length savings of 2.3% compared to an existing industry-standard tool solution, and it avoided collision with 13 wells. Also, the total time taken for designing 36 collision-free optimized wells was reduced from months (as per the industry standard) to a couple of days.
Factors Affecting Capital Structure Decisions of Banks: A Systematic Literature Review Evidence from Commercial Banks of Ethiopia
Authors: Gofe Tesfaye Eresso , Asfaw Arega Seyoum 
Published: June 2023

Abstract
The study intends to examine the literature on factors influencing capital structure decisions of commercial banks in Ethiopia in order to identify existing gaps and the degree of existing research in the subject, as well as to provide direction for future research. Due to a lack of studies for the stated review and access to the known database, the review was conducted utilizing eleven relevant and available scholarly papers that were published in any time period, primarily using open search engines and databases. To identify the articles, various key words were employed. The PRISMA framework was used to analyze the capital structure decisions study work. The review protocol outlined the inclusion and exclusion criteria. The descriptive analysis was performed based on different parameters to arrive at conclusions. The findings revealed that most of the variables of interest explored in the studies contradicted each other and the previous literature variables. The capital structure studies were conducted by considering few variables, and most of the studies were not cited. The findings regarding the theories supported by factors affecting the capital structure decisions of commercial banks in Ethiopia were contradictory and not justified. The banking literature still doesn't cover the capital structure of banks very much. There is currently a lack of clarity regarding how banks determine their capital structure and what variables affect their corporate financing behaviour. Therefore, it is recommended that the concerned body conduct an in-depth study of the decisions banks make about their capital structure by identifying pertinent elements.
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer’s disease
Authors: Cruchaga Carlos , Western Dan , Timsina Jigyasha , Wang Lihua , Wang Ciyang , Yang Chengran , Ali Muhammad , Beric Aleksandra , Gorijala Priyanka , Kohlfeld Patsy , Budde John , Levey Allan , Morris John , Perrin Richard , Ruiz Agustín , Marquié Marta , Boada Mercè , de Rojas Itziar , Rutledge Jarod , Oh Hamilton , Wilson Edward , Guen Yann Le , Alvarez Ignacio , Aguilar Miquel , Greicius Michael , Pastor Pau , Pulford David , Ibanez Laura , Wyss-Coray Tony , Sung Yun Ju , Phillips Bridget 
Published: June 2023

Abstract

The integration of quantitative trait loci (QTL) with disease genome-wide association studies (GWAS) has proven successful at prioritizing candidate genes at disease-associated loci. QTL mapping has mainly been focused on multi-tissue expression QTL or plasma protein QTL (pQTL). Here we generated the largest-to-date cerebrospinal fluid (CSF) pQTL atlas by analyzing 7,028 proteins in 3,107 samples. We identified 3,373 independent study-wide associations for 1,961 proteins, including 2,448 novel pQTLs of which 1,585 are unique to CSF, demonstrating unique genetic regulation of the CSF proteome. In addition to the established chr6p22.2-21.32 HLA region, we identified pleiotropic regions on chr3q28 near OSTN and chr19q13.32 near APOE that were enriched for neuron-specificity and neurological development. We also integrated this pQTL atlas with the latest Alzheimer’s disease (AD) GWAS through PWAS, colocalization and Mendelian Randomization and identified 42 putative causal proteins for AD, 15 of which have drugs available. Finally, we developed a proteomics-based risk score for AD that outperforms genetics-based polygenic risk scores. These findings will be instrumental to further understand the biology and identify causal and druggable proteins for brain and neurological traits.
Earthworms do not increase greenhouse gas emissions (CO2 and N2O) in an ecotron experiment simulating a realistic three-crop rotation system
Authors: Forey Oswaldo , Sauze Joana , Piel Clément , Gritti Emmanuel , Devidal Sébastien , Faez Abdelaziz , Ravel Olivier , Nahmani Johanne , Rouch Laly , Blouin Manuel , Perez Guenola , Capowiez Yvan , Roy Jacques , Milcu Alexandru 
Published: June 2023

Abstract
Earthworms are known to stimulate soil greenhouse gas (GHG) emissions, but previous studies have used simplified models or had limited measurements. To address this, we conducted a two-year study using large lysimeters in an ecotron facility, continuously measuring ecosystem-level CO2, N2O, and H2O fluxes. We investigated the impact of endogeic and anecic earthworms on GHG emissions and ecosystem water use efficiency (WUE) in an agricultural setting. Although we observed transient stimulations of carbon fluxes in the presence of earthworms, cumulative fluxes over the study indicated no significant increase in CO2 emissions. Endogeic earthworms marginally reduced N2O emissions during the wheat culture (-44.6%), but this effect was not sustained throughout the experiment. No consistent effects on ecosystem evapotranspiration or WUE were found. Our study suggests that earthworms do not significantly contribute to GHG emissions over a two-year period in experimental conditions that mimic an agricultural setting. These findings highlight the need for realistic experiments enabling continuous GHG measurements.
Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179
Authors: Li Yuchen , Lim Chaemin , Dismuke Taylor , Malawsky Daniel , Oasa Sho , Bruce Zara , Offenhäuser Carolin , Baumgartner Ulrich , D'Souza Rochele , Edwards Stacey , French Juliet , Ock Lucy , Nair Sneha , Sivakumaran Haran , Harris Lachlan , Tikunov Andrey , Hwang Duhyeong , Pauneto Coral Del Mar Alicea , Maybury Mellissa , Hassall Timothy , Wainwright Brandon , Kesari Santosh , Stein Gregory , Piper Michael , Johns Terrance , Sokolsky-Papkov Marina , Terenius Lars , Vukojevic Vladana , Day Bryan , Gershon Timothy 
Published: June 2023

Abstract

Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated the anti-tumor potential of the small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, patient-derived xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB. CT-179 disrupted OLIG2 dimerization, DNA binding and phosphorylation and altered tumor cell cycle kinetics in vitro and in vivo, increasing differentiation and apoptosis. CT-179 increased survival time in GEMM and PDX models of SHH-MB, and potentiated radiotherapy in both organoid and mouse models, delaying post-radiation recurrence. Single cell transcriptomic studies (scRNA-seq) confirmed that CT-179 increased differentiation and showed that tumors up-regulated Cdk4 post-treatment. Consistent with increased CDK4 mediating CT-179 resistance, CT-179 combined with CDK4/6 inhibitor palbociclib delayed recurrence compared to either single-agent. These data show that targeting treatment-resistant MB stem cell populations by adding the OLIG2 inhibitor CT-179 to initial MB treatment can reduce recurrence.
Non-genetic variables influence disposal patterns in Murrah and Nili-Ravi buffaloes
Authors: Tamboli Pooja , Bharadwaj Anurag , CHAURASIYA Amit Kumar , Bangar Yogesh , Khanna Sudhir , Singh Kunwar Pal 
Published: June 2023

Abstract
The current study was carried out to look into the disposal patterns of Murrah and Nili-Ravi buffaloes kept at ICAR-CIRB, Hisar and Sub-Campus Nabha, Punjab, respectively. The purpose of the investigation was to estimate the various non-genetic factors affecting culling and mortality patterns in buffaloes to suggest suitable health management practices, selection, and breeding strategies for enhancing genetic gain in buffaloes. From 1983 to 2017, 1180 data of 679 Murrah and 501 Nili-Ravi were used to calculate the frequency of culling and death. The impacts of several parameters on disposal were explored, including breed, period of disposal, season of disposal, and lactation completed. The findings revealed that in Murrah, 90.72% of buffaloes were disposed of due to culling and 9.28% due to mortality. While, in the instance of Nili-Ravi, animal disposal due to culling accounted for 89.62% of the total, with mortality accounting for 10.38%. The main reason for culling was old age and low production, while the majority of buffaloes died from cardiovascular, digestive, and respiratory problems. Furthermore, the effect of season was highly significant (p < 0.001) on the pattern of culling in buffaloes. Additionally, majority of the animals culled in the winter season, followed by summer and most of the animals culled were old aged (45 and 22%), low yielder (35 and 27%) and affected with mastitis (30 and 28%), respectively in both the winter and summer seasons. Moreover, the effect of period of disposal was highly significant (p < 0.001) on the both pattern of mortality and culling in buffaloes. Further, maximum (34%) number of animals culled in the period 1994-98 due to old age whereas lowest culling rate (3%) was seen during 2014 to 2018. In this sequence, it may be determined that the reason for disposal differs depending on the breed, period, season and lactation completed.As a result, our efforts should be directed towards improving management practices with the goal of lowering the rate of culling and mortality, which leads to higher lifetime performance and, as a result, the overall efficiency of the dairy farm.
Evaluation of Pro- and Anti-Inflammatory Cytokines in Glioma Patients: Correlation with Tumor Grading
Authors: Jadhav Nithin Kumar , Sangaraju Rajendra , Mudumba Vijayasaradhi , Ara Dilkash , Dheeravath Srinivas , Alugolu Rajesh , Gowda Pavan Swamy , Kedasi Raghuram , Pishe Vishal Manohar , Sinha Sukesh Narayan , Gouda Balaji , Mungamuri Sathish Kumar 
Published: June 2023

Abstract
Objective and design:
In this case control observational study of glioma patients, using ELISA technique, we have examined the tissue cytokine profile of pro- and anti-inflammatory cytokines (IFN-γ, IL-6, IL-1β, IL-8, TNF-α and IL-10, IL-4), and angiogenic factors (VEGF, FGF-2), and compared with the tumor type and stage. We found that a significant upregulation of pro-inflammatory cytokines (IFN-γ, IL-6, IL-1β, IL-8, and TNF-α), and a significant down regulation of anti-inflammatory cytokines (IL-10, and IL-4) compared to control brain tissues. Similarly, when compared to control group, we found a significant increase in angiogenic cytokines (VEGF, FGF-2) in tumor tissues.
Methodology:
We have examined the tissue cytokine profile of pro- and anti-inflammatory cytokines (IFN-γ, IL-6, IL-1β, IL-8, TNF-α, and IL-10, IL-4), as well as angiogenic factors (VEGF, FGF-2), in order to evaluate tumoral aggressiveness by using ELISA technologies.
Result
Our results suggest that even though there is a significant alteration in the cytokines between the control and tumor samples, we found that the difference between various glioma grades and meningioma are not statistically significant. Based on our results we conclude that the cytokine levels alone may not be suitable enough for tumor staging.
Conclusion
These cytokines contribute to the development of pain associated with the disease as well as the growth and aggressiveness of tumours. With a focus on cytokines, our goal in this study is to investigate the microenvironment of gliomas. Pain is one of the main symptoms of glioblastoma, but it might be delayed or neglected. Cytokines might accelerate diagnosis and treatment.
Structural and biological characterization of shortened derivatives of the cathelicidin PMAP-36
Authors: Biondi Barbara , De Pascale Luigi , Mardirossian Mario , Stasi Adriana Di , Favaro Matteo , Scocchi Marco , Peggion Cristina 
Published: June 2023

Abstract
Cathelicidins, a family of host defence peptides in vertebrates, play an important role in the innate immune response, exhibiting antimicrobial activity against many bacteria, as well as viruses and fungi. This work describes the design and synthesis of shortened analogues of bovine cathelicidin PMAP-36, which contain structural changes to improve the pharmacokinetic properties. In particular, 20-mers based on PMAP-36 (residues 12–31) and 13-mers (residues 12–24) with modification of amino acid residues at critical positions and introduction of lipid moieties of different lengths were studied to identify the physical parameters, including hydrophobicity, charge, and helical structure, required to optimise their antibacterial activity. Extensive conformational analysis, performed by CD and NMR, revealed that the substitution of Pro25-Pro26 with Ala25-Lys26 increased the α-helix content of the 20-mer peptides, resulting in broad-spectrum antibacterial activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus epidermidis strains. Interestingly, shortening to just 13 residues resulted in only a slight decrease in antibacterial activity. Furthermore, two sequences, a 13-mer and a 20-mer, did not show cytotoxicity against HaCat cells up to 64 µM, indicating that both derivatives are not only effective but also selective antimicrobial peptides. In the short peptide, the introduction of the helicogenic α-aminoisobutyric acid forced the helix toward a prevailing 310 structure, allowing the antimicrobial activity to be maintained. Preliminary tests of resistance to Ser protease chymotrypsin indicated that this modification resulted in a peptide with an increased in vivo lifespan. Thus, some of the PMAP-36 derivatives studied in this work show a good balance between chain length, antibacterial activity, and selectivity, so they represent a good starting point for the development of even more effective and proteolysis-resistant active peptides.
Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia
Authors: Aschner Judy , Avachat Charul , Birnbaum Angela , Sherwin Catherine , Fike Candice 
Published: June 2023

Abstract
Objective. Information is needed to guide the design of randomized controlled trials (RCTs) evaluating L-citrulline as a therapy for premature infants with pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH). Our goal was to evaluate the tolerability and ability to achieve a target steady-state L-citrulline plasma concentration in prematures treated enterally with a multi-dose L-citrulline strategy based on our single-dose pharmacokinetic study.
Study Design. Six prematures received 60 mg/kg of L-citrulline every 6 hours for 72 hours. Plasma L-citrulline concentrations were measured before the first and last L-citrulline doses. L-citrulline concentrations were compared to concentration-time profiles from our previous study.
Results.Plasma L-citrulline concentrations agreed with the simulated concentration-time profiles. No serious adverse events occurred.
Conclusions. Simulations based on single-doses can be used to predict target multi-dose plasma L-citrulline concentrations. These results assist the design of RCTs evaluating the safety and effectiveness of L-citrulline therapy for BPD-PH. Clinical trials.gov ID: NCT03542812
Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study
Authors: Su Wei , Gao Yuzhen , Wang Xiaoling , Wang Donghai , Feng Binbin , Wu Yinshan , Zheng Huijun , Guo Feng 
Published: June 2023

Abstract
Background
The effect of double filtration plasma apheresis (DFPP) on improving the outcomes of patients with hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains unclear. The aim of this study was to evaluate the relationship between the initiation time of DFPP and the risk of persistent organ failure (POF) in an HTG-AP cohort in China.
Methods
We retrospectively evaluated data from HTG-AP patients treated with DFPP 48 hours after diagnosis between January 2017 and January 2022. Comparisons across tertiles of the interval from diagnosis to completion of one DFPP session (DTD) were analysed. Logistic regression models and restricted cubic splines (RCS) were used to determine the correlation between the DTD time and risk of POF.
Results
Of the 89 patients enrolled, 46 patients (51.69%) suffered POF in the first week of HTG-AP. DFPP was initiated at a median of 17 hours after the diagnosis was confirmed. The patients in the highest tertile of DTD time had a significantly increased prevalence of POF. After multivariate adjustment, the logistic regression models found a significant decrease in the odds ratios (OR) of POF from the highest to the lowest DTD tertile (P for trend = 0.006). Moreover, the RCS curves showed a nonlinear relationship in the adjusted OR of POF and DTD time, which remained relatively low and flat during the early DTD time but increased sharply afterwards.
Conclusion
Early initiation of DFPP treatment correlates with a reduced risk of POF in HTG-AP patients.