bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbilical cord mesenchymal stem cell alleviates asthma via Nrf2/HO-1/NF-κB signaling pathway
Authors: Lin Yiping , Lin Xinxiao , Wu Xiangjie , Ying Xiaoqian , Yu Qian , Chen Li , Pan Huiying , Wu Xiaoyu 
Published: April 2023

Abstract
Background Numerous previous studies have proved the immunomodulatory properties of mesenchymal stem cells (MSCs) especially for human umbilical cord mesenchymal stem cells (UC.MSCs) in the progression of asthma, but the action mechanism remains unclear.Methods In the present work, a rat asthma model induced by ovalbumin (OVA) was established to ascertain the effects of UC.MSCs treatment on inflammation, oxidative stress and airway remodeling. Additionally, both in rat asthma model and TGF-β-induced airway smooth muscle cells (ASMCs), the interaction of UC.MSCs with Nrf2/HO-1/NF-κB pathway was evaluated.Results We demonstrated that OVA-induced inflammation infiltration and the increase of cell counts of eosinophils, lymphocytes, and macrophages were dramatically reduced after UC.MSCs treatment. The downregulated expression of anti-oxidant genes (NQO1 and HO-1), and the reduced GSH levels caused by OVA challenge were restored following the treatment of UC.MSCs. Meanwhile, UC.MSCs also prohibited collagen deposition, suppressed goblet cell hyperplasia and decreased the levels of airway remodeling markers (α-SMA, TGF-β1, MMP9 and TIMP1) in asthma rat model. In in vitro experiments, TGF-β could facilitate the viability of ASMCs and restrain G1 cell cycle arrest, while UC.MSCs revised these changes. Additionally, treatment with UC.MSCs could significantly activate the expression of HO-1 and NRF2, but inhibit NF-κB levels in vivo and in vitro.Conclusions In a word, these findings indicated that UC.MSCs can alleviate asthma via Nrf2/HO-1/NF-κB signaling pathway, which provided a theoretical basis for asthma therapy in clinic.
Dispersion complexity-entropy curves: an effective method to detect the structures of complex systems
Authors: Jiang Runze , Shang Pengjian , Zhang Boyi 
Published: April 2023

Abstract
Complexity-entropy curves(CEC) is a useful tool to detect the structure of time series. It’s widely applied in many research areas since it can distinguish the chaotic system and the stochastic process well. However, the original permutation complexity-entropy curves(PCEC) based on permutation entropy(PE) has a defect for it can not take means and amplitudes of time series into consideration, which may lead to some errors when distinguishing the systems. In this paper, we propose dispersion complexity-entropy curves(DCEC) to overcome the defects of PCEC. In addition, we expand the curves from two-dimension to threedimension. We first compare DCEC with PCEC by simulated data. The result shows that DCEC are not only more distinguishable but also more robust with the change of parameters when detecting periodic series. Then, we apply our method to real-world data to illustrate its practicability. We propose a creative feature extraction method based on DCEC and combine it with MSVM to diagnose the different types of bearing fault, which obtains perfect results for the accuracy achieves 100%. We also apply DCEC to stock indices in different countries and different periods to analyze the complexity degree of financial markets. The results successfully detect American financial crisis in 2008 and the rapid development of the economy in China during 2014-2018. These demonstrate that DCEC can serve as an effective method to analyze complex systems.
Low ratio of IL-10 to IFN-γ and Low IL-10 level indicate good prognosis in Salmonella enterica serovar Typhimurium triggered secondary hemophagocytic lymphohistiocytosis: a case report and literature review
Authors: Chen Yuanyuan , Liang Lingfang , Xu Xiangzhi , Lin Shupeng , Xu Xiaojun 
Published: April 2023

Abstract
Background: Secondary hemophagocytic lymphohistiocytosis triggered by Salmonella enterica serovar Typhimurium is rare in pediatric patients. There is a specific cytokine pattern to differentiate HLH subtypes, including IFN-γ, IL-10, and IL-6, and the ratio of IL-10 to IFN-γ, which can guide HLH treatments choice.
Case presentation: We present a pediatric 9-year old patient who presented with fever and pancytopenia for three days into our hospital, who showed positive results of Salmonella enterica serovar Typhimurium, Human Rhino Virus and Mycoplasma Pneumoniae infections. At the time of admission to our institution, the patient’s Th1/Th2 cytokine results showed that IL-6 was 326 pg/ml, IL-10 was 9.1 pg/ml, and IFN-γ was 246.7 pg/ml, with a ratio of IL-10 to IFN-γ was 0.04. In this study, this patient received meropenem, linezolid, and cefoperazone/sulbactam for anti-infection therapy, combined with high dose methylprednisolone therapy and anti-shock supportive treatments for twice. After careful evaluation, this patient did not receive HLH chemotherapy during the whole disease course, and he recovered well.
Conclusions: Early antimicrobial and supportive treatment would be enough for Salmonellatriggered sHLH with a ratio of IL-10 to IFN-γ ≤ 1.33, and IL-10 ≤ 10.0 pg/ml, and/or IFN-γ ≤ 225 pg/ml on admission, and HLH-94/2004 protocol was not necessary in such condition.
Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children
Authors: Lv Yan , Fu Rui , Peng Xiao-Jie , Wang Ying , Yin Ting-Ting , Deng Yan-Qing 
Published: April 2023

Abstract
Background Although IgA vasculitis nephritis (IgAVN) and IgA nephropathy (IgAN) have many clinical and pathological parallels, they also have some differences, and their relationship has not yet been determined. This paper examines the differences in clinicopathology and prognosis between kids with IgAVN and IgAN. Methods We retrospectively analyzed the data of 809 children with IgAVN and 236 children with IgAN between January 2006 and December 2021 to compare the similarities and differences between IgAVN and IgAN in clinicopathology and prognosis. Results IgAN was more prevalent in the summer, whereas IgAVN was more common in the fall (P < 0.0001). IgAN tubular interstitial injury is more severe, chronicity index and total biopsy score were higher than IgAVN (P < 0.0001). The deposition intensity of C3, and the deposition rate of IgA pure in the mesangium, were higher in IgAVN than in IgAN (P < 0.0001), and the intensity of IgA deposition was also higher in IgAVN (P = 0.003). IgAVN had a better prognosis and a higher kidney remission rate (P < 0.0001). Cox regression revealed interstitial fibrosis as an independent risk factor for poor prognosis of IgAVN (HR = 1.449, 95%CI:1.011–2.076, P = 0.043) and IgAN (HR = 2.384, 95%CI:1.313–5.024, P = 0.022). Furthermore, IgA++ (HR = 2.25, 95%CI:1.212–4.175, P = 0.01) and IgA+++ (HR = 12.043, 95%CI:1.498–96.854, P = 0.019) could be risk factors for bad prognosis of IgAVN. Conclusions IgAN was more severe than IgAVN regarding kidney impairment, interstitial damage, and prognosis. There were different levels and locations of immune complex deposition in the kidneys, supporting the notion that they are two distinct diseases. The intensity of IgA deposition may be a risk factor for poor IgAVN prognosis.
Health management service models for the elderly with visual impairment ： a scoping review
Authors: Dong Yu , Wang Aiping 
Published: April 2023

Abstract
Background The incidence of visual impairment(VI ) in older people is gradually increasing. This review aimed to summarise the evidence on existing health management models and strategies for older adults with VI to improve health-related and vision-related quality of life (QoL) in older people.Methods Based on the framework of the scoping review methodology of Arksey and O'Malley (2005), a comprehensive literature search of relevant literature published between January 2010 and June 2022 in PubMed, CINAHL, EMBASE, Web of Science, Cochrane Library, CNKI, VIP, Wanfang database, Sinomed and the grey literature.Results Finally, 31 articles were included. The health management model had a multidisciplinary team low vision rehabilitation model, medical consortium two-way management model, low vision community comprehensive rehabilitation model, medical consortium-family contract service model, screening-referral-follow-up model, and three-level low vision care model. The health management strategy covers nine aspects, the combination of multi-element strategies is feasible, and network information technology has also shown positive results.Conclusions In the future, under the Internet and hierarchical management model, we should provide demand-based personalized support to rationalize and scientifically achieve hierarchical management and improve resource utilization efficiency and eye health outcomes.
Serum Krebs von den Lungen-6 level as a prognostic biomarker in patients with interstitial lung abnormalities
Authors: Kang Hyung Koo , Kang Jiyeon , Seo Woo Jung , Kang Jieun , Park So-Hee , Koo Hyeon-Kyoung , Park Hye Kyeong , Lee Sung-Soon , Shin Jong Wook 
Published: April 2023

Abstract
Data associating progression of interstitial lung abnormalities (ILA) and serum biomarkers, including white blood cell differential counts and Krebs von den Lungen-6 (KL-6) are sparse. This study aimed to evaluate the relationship between disease progression and serum biomarkers in patients with ILA. This retrospective cohort study collected data, such as clinical characteristics, pulmonary function test, chest computed tomography (CT), complete blood cell counts, and KL-6 levels from 159 patients (63 with ILA and 74 with interstitial lung diseases [ILDs]) from October 2021 to September 2022. In 42 patients who had previously undergone chest CT, the risk factors for radiologic progression was evaluated using the receiver operating characteristic curve analysis and multivariate logistic regression. Among the 42 patients with ILA, 12 showed radiological progression. Serum KL-6 showed moderate performance with area under the curves ranging from 0.60–0.93 (p = 0.008) for radiological progression. In multivariate analysis, fibrotic ILA (odds ratio [OR] 6.99; 95% confidence interval [CI], 1.12–43.5) and KL-6 > 400 U/mL (OR, 6.52; 95% CI, 1.14–37.2) were associated with radiological progression. Serum KL-6 level is a reliable indicator of progression of ILA in asymptomatic patients. Patients with serum KL-6 > 400 U/mL require careful observation for radiological progression.
Prevalence, trends and individual patterns of long-term antidepressants medication use in the adult Swiss general population, 2013 - 2021
Authors: Amrein Melanie A. , Hengartner Michael P. , Näpflin Markus , Farcher Renato , Huber Carola A. 
Published: April 2023

Abstract
Purpose: Antidepressant use has increased in many European countries, mostly driven by longer treatment duration. The aim of this study was to provide prevalence rates of long-term users of antidepressants for the Swiss population over the last decade and to investigate associated factors for longer use.
Methods: We examined the prevalence rates of individuals with at least one prescription for antidepressants using longitudinal health claims data. To compare different lengths of prescription duration, we defined short-term (<6 months), medium-term (6-12 months) and long-term users (>12 months). We applied a binary logistic regression model to investigate the effects of population characteristics and treatment patterns on long-term compared to short- and medium-term users.
Results: In 2021, 9% of the Swiss population (n=770 698) received at least one antidepressant prescription. This one-year-prevalence remained stable since 2013. In 2020, the proportion of long-term users was 69.4%, with steady increase from 2014 to 2020. The numbers of medium- and short-term users have decreased during this period. Older age, being a woman, living in an urban area, living in the Italian speaking part of Switzerland, living in a nursing home, being enrolled in a standard care plan, and receiving psychiatric or psychotherapeutic care were factors associated with long-term users.
Conclusion: The proportion of long-term users in Switzerland is steadily increasing. Taking antidepressants longer than recommended may indicate possible overprescribing. Given the ongoing debate about the confounding effects of relapse and withdrawal, more research is needed to investigate antidepressants overprescribing, particularly for older people.
Entanglement propagation and dynamics in non-additive quantum systems
Authors: Giachetti Guido , Defenu Nicolo 
Published: April 2023

Abstract
The prominent collective character of long-range interacting quantum systems makes them promising candidates for quantum technological applications. Yet, lack of additivity overthrows the traditional picture for entanglement scaling and transport, due to the breakdown of the common mechanism based on excitations propagation and confinement. Here, we describe the dynamics of the entanglement entropy in many-body quantum systems with a diverging contribution of the long-range two body potential to the internal energy. While in the strict thermodynamic limit entanglement dynamics is shown to be suppressed, a rich mosaic of novel scaling regimes is observed at intermediate system sizes, due to the possibility to trigger multiple resonant modes in the global dynamics. Quantitative predictions on the shape and timescales of entanglement propagation are made, paving the way to the observation of these phases in current quantum simulators. This picture is connected and contrasted with the case of local many body systems subject to Floquet driving.
Simplified models of aerosol collision and deposition for disease transmission
Authors: Jung Sunghwan 
Published: April 2023

Abstract
Fluid-mechanics research has focused primarily on droplets/aerosols being expelled from infected individuals and transmission of well-mixed aerosols indoors. However, aerosol collisions with susceptible hosts earlier in the spread, as well as aerosol deposition in the nasal cavity, have been relatively overlooked. In this paper, two simple fluid models are presented to gain a better understanding of the collision and deposition between a human and an aerosol. The first model is based on the impact of turbulent diffusion coefficients and air flow in a room on the collisions between aerosols and humans. Infection rates can be determined based on factors such as air circulation and geometry as an infection zone expands from an infected host. The second model clarifies how aerosols of different sizes adhere to different parts of the respiratory tract. Based on the inhalation rate and the nasal cavity shape, the critical particle size and the deposition location can be determined. Our study offers simple fluid models to understand the effects of geometric factors and air flows on the aerosol transmission and deposition.
Efflux pump genes variants in MDR TB strains with discrepant phenotype-genotype correlations may further guide drug resistance interpretation
Authors: Hasan Zahra , Razzak Safina Abdul , Kanji Akbar , Shakoor Sadia , Hasan Rumina 
Published: April 2023

Abstract
Introduction: Whole genome analysis of Mycobacterium tuberculosis (MTB) is an increasingly important method of identification of multi-drug resistance (MDR) in clinical isolates. It is based on the identification of single nucleotide variants (SNVs) in genes associated with resistance. However, there remain gaps in our understanding of phenotype – genotype correlation between strains. Efflux pumps contribute to drug resistance and here we studied SNVs in key efflux pump genes (EP) to investigate their association with resistance.
Methods: Whole genome data of 2221 MTB isolates comprising 1432 susceptible and 789 drug resistant strains were downloaded from ReSeqTB database. MTB lineage and resistance genotyping analysis was performed using an in-house bioinformatics pipeline, MTB-VCF. SNVs in 47 EP genes were categorized according to their SIFT/Polyphen scores.
Results: We identified variants unique to EP in DR isolates. SIFT/Polyphen effect analysis determined 38 high impact SNVs across twenty EP genes (EP) to be present in these 789 genomes. SNVs were not associated with MTB lineages. The EPs with SNVs in DR isolates were Rv1819, Rv0194, Rv0507, Rv2333c, Rv3728, Rv3823, Rv1250, Rv1273, Rv1458, Rv1634, Rv1217, Rv1218, Rv0450, Rv0676c, Rv0191, Rv3008, Rv3756, Rv2688, Rv1704 and Rv1877. Examination of 52 isolates with discrepant phenotype-genotypes resistance comprising, MDR, pre-XDR and XDR strains revealed SNVs in EP associated with RIF and INH (Rv0194, Rv1217_1218, Rv1819, Rv0450, Rv1458, Rv0507), and those associated with fluoroquinolone (Rv1634 and Rv2688) resistance.
Conclusions: We identified SNVs in efflux pumps which could contribute to resistance in MTB strains. It may be important to consider these as part of MTB genome-based resistance interpretation. Functional studies combined with GWAS and RNA profiling would further confirm these findings.
Challenges of considering both extremities of the weight status spectrum to better understand obesity: Insights from the NUTRILEAN Project in Constitutionally Thin Individuals.
Authors: BAILLY Mélina , BOSCARO Audrey , Verney Julien , Tremblay Angelo , King James , Pereira Bruno , COSTES Frédéric , JULIAN Valérie , Duclos Martine , Boirie Yves , Thivel David , BAILLY Mélina 
Published: April 2023

Abstract
While the physiology of obesity has been so extensively investigated to date, only an extremely small number of studies (less than 50) have focused on the other extremity of the weight spectrum: constitutional thinness. Yet, this important state of underweight in the absence of any eating disorders provides a mirror model of obesity that might be particularly insightful in understanding obesity. Nevertheless, important methodological and recruitment-related issues appear when it comes to this complex constitutionally thin phenotype, as experienced by our research group with the realization of the ongoing NUTRILEAN clinical trial. To face this challenge, the present paper aims at identifying, analysing, and discussing the quality of such recruitment processes in publications about constitutional thinness. In this order, a group of experts collectively created a new grading system to assess the level of rigor and quality achieved by each study based on different criteria. The main results were that (i) metabolic-related biasing criteria were poorly observed despite being crucial, (ii) recruitment processes were not detailed enough and with sufficient explicitness, and (iii) recruiting among already identified patients would be associated with both higher sample sizes and better scores of quality. The present work encourages investigators to adopt a high level of rigor despite the complexity and duration of recruitment processes for this specific population, and readers to pay close attention to the quality of recruitment when interpreting the data. To better understand obesity and its physiological adaptations, it seems essential not only to compare it to normal-weight conditions, but also to the other extremity of the weight status spectrum represented by constitutional thinness.
Foxg1 modulation of the Prkcd gene in the lateral habenula mediates trigeminal neuralgia-associated anxiety-like behaviors in mice
Authors: Abudula Aji , Zhang Chen , Chen Teng , Liu Wen-Bo , Mi Wen-Li , Mao-Ying Qi-Liang , Wang Yan-Qing , Chu Yu-Xia 
Published: April 2023

Abstract
Trigeminal neuralgia (TN) is a debilitating condition and often leads to mood disorders such as depression and anxiety. The present study aimed to determine the molecular mechanisms involved in the pathogenesis of TN and its associated anxiety. We found that partial transection of the infraorbital nerve (pT-ION) in mice induced stable and long-lasting primary and secondary orofacial allodynia and anxiety-like behaviors. Gene microarray analysis found that Foxg1 expression was significantly upregulated after pT-ION, and knocking down Foxg1 by microinjection of adeno-associated virus carrying Foxg1 shRNA into the bilateral lateral habenula (LHb) effectively alleviated pain-related and anxiety-like behaviors. RNA sequencing showed that Prkcd may be the downstream gene modulated by Foxg1. Pharmacological inhibition of protein kinase C delta, the Prkcd-encoded protein, in the LHb effectively reversed pT-ION-induced pain-related and anxiety-like behaviors. Dual luciferase reporter analysis indicated the direct promotion of Prkcd gene expression by Foxg1. In conclusion, trigeminal nerve injury induced the upregulation of Foxg1 in the LHb, which promoted the expression of Prkcd, thus resulting in orofacial pain and anxiety-like behaviors. This finding provides potential therapeutic targets and a theoretical basis for the clinical treatment of TN and its associated anxiety.
Impact of a Guaranteed Access Program to Imatinib on the Survival of Patients with Chronic Myeloid Leukemia
Authors: Lampon Gilberto Barranco , Vidal Itzel , Gama Dulce , Martínez Carlos , Acosta Brenda , Ramos Christian , Martínez Emmanuel , Zazueta Juan , Olarte Irma , Martínez Adolfo , Cervera Eduardo , Mendoza Iveth , Arcos Diana , Cruz Judith 
Published: April 2023

Abstract

Purpose: This work aimed to evaluate the impact of a guaranteed access program to Imatinib on the survival of patients with Chronic Myeloid Leukemia
Methods: We carried out a retrospective, observational, and analytical study of the database of patients diagnosed with Chronic Myeloid Leukemia of the Instituto Nacional de Cancerología and the Hospital General de México Dr. Eduardo to assess overall survival based on guaranteed access or not to Imatinib.
Results: With an average follow-up of 99 months, the estimated 20-year overall survival for all patients was 72% (95% CI, 76-67). A significant difference was found in the 20-year survival probability in favor of patients with guaranteed access 76% (95% CI, 81-71) vs. 61% (95% CI, 69-52) (p<0.001), in addition to those in which they had better attachment 81.2% (95% CI, 85-76) vs. 44.9% (95% CI, 52-37) (p<0.001).
Conclusion: CML is the most frequent chronic leukemia in Mexico, it mainly affects the economically active population (mean age 40), and the prognosis in our country has improved, emulating developed countries; however, the results depend on access to treatment as well as proper monitoring.