bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosserat Rod-Based Dynamic Modeling of Tendon-Driven Continuum Robots: A Tutorial
Authors: Janabi-Sharifi Farrokh 
Published: August 2023

<p>This article provides a tutorial on the dynamic modeling of continuum robots. Continuum robots (CRs) have gained popularity in recent years due to their flexible backbone structure. Modeling and control of CRs motivate accurate and efficient dynamic models. Such models will enable simulation of dynamic behavior, improved structural design, and the development of dynamics-based control systems for CRs. As a unified underlying approach, the Cosserat rod-based modeling of tendon-driven CRs is used as the basis of the modeling techniques discussed in this paper. In addition to conventional continuum robot assemblies, new and emerging assemblies such as tendon-bent concentric tube and co-operative robots are also considered. The governing equations of motion for conventional CRs are first summarized and then extended for other tendon-driven CRs. This tutorial also contributes to developing a MATLAB code package for simulation of the dynamic response of these robots. The presented method and codes provide a useful and compact resource for readers and can be used for further development of tendon-driven continuum robots. </p>
Comparison of Reducing the Speckle Noise in Ultrasound Medical Images using Discrete Wavelet Transform
Authors: Khan Asim ur Rehman , Janabi-Sharifi Farrokh , Ghahramani Mohammad , Khan Muhammad Ahsan Rehman 
Published: August 2023

<p>Speckle noise in ultrasound (US) medical images is the prime factor that undermines its full utilization. This noise is added by the constructive / destructive interference of sound waves travelling through hard- and soft-tissues of a patient. It is therefore generally accepted that the noise is unavoidable. As an alternate researchers have proposed several algorithms to somewhat undermine the effect of speckle noise. The discrete wavelet transform (DWT) has been used by several researchers. However, the performance of only a few transforms has been demonstrated. This paper provides a comparison of several DWT. The algorithm comprises of a pre-processing stage using Wiener filter, and a post-processing stage using Median filter. The processed image is compared with the original image on four metrics: two are based on full-reference (FR) image quality assessment (IQA), and the remaining two are based on no-reference (NR) IQA metrics. The FR-IQA are peak signal-to-noise ratio (PSNR) and mean structurally similarity index measure (MSSIM). The two NR-IQA techniques are blind pseudo-reference image (BPRI), and blind multiple pseudo-reference images (BMPRI). It has been demonstrated that some of these wavelet transforms outperform others by a significant margin. </p>
Pandangan Hukum Keluarga Islam terhadap Manajemen Konflik Ekonomi Dalam Rumah Tangga
Authors: Permasari Rama Dhini 
Published: August 2023

This paper discusses about Islamic Family Law View on Economic Conflict Management in the Household. This research is motivated by the findings of many previous research results regarding the high divorce rate, the main cause of which is due to economic problems in the household. It is important to study how Islamic Family Law provides solutionsto economic problems that occur between husband and wife so that divorce can be avoided. His research is included in the type of library research (library research). To process the data that the author has obtained. So the authors analysis using content analysis techniques (content analysis). The results of this research is incuded in the type of library research. To process the data that the authors analyza using content analysis techniques. The result of this study reveal that the solutions for resolving economic conflict in the household in the view of islamic Famiy Law include: the husband fulfills the rights of his wife, the wife must know when she has the right to earn a living from her husband, the wife must know when she has the right to earn a livingfrom her husband, the wife must not demand rights beyond the limits of the husband’s ability, the wife must be patient and sincere with her husband.
ESENSI JAMINAN FIDUSIA DAN RAHN DALAM PELAKSANAAN EKSEKUSI JAMINAN KEBENDAAN
Authors: Andriyani Gina , Alamudi Ichwan Ahnaz 
Published: August 2023

The background of economic development in Indonesia includes sectors related to business activities carried out by business people who will always hold back the flow of developing consumptive needs by requiring guarantees to fulfiil the credit facilities provided. This paper discusses the problem in the form of collateral execution if the debtor defaults, both by law and Islamic law. This study used the library research method and used a normative appoarch with a juridical approach. Based on the results of this paper, it can be concluded that the implementation of the execution of fiduciary guarantees based on the fiduciary guarantees act, has a new perspective in its implementation and has similarities with rahn according to Islamic law which can be combined with rahn tasjily in material guarantees
Estudio sobre ecuaciones diferenciales ordinarias lineales no homogéneas de coeficientes constantes por el método de integrales sucesivas
Authors: Insuasti Castelo Rómel Manolo , Mendoza Castillo Javier Roberto , Cepeda Silva Patricia Mercedes 
Published: August 2023

Introducción: Al resolver las ecuaciones diferenciales lineales no homogéneas de coeficientes constantes, es necesario encontrar una solución que corresponde a la parte homogénea y una parte corresponde a la parte no homogénea o particular de la función , cuando esta tiene la forma , donde “a” es una de las raíces correspondiente los factores de la ecuación característica de la ecuación diferencial, se presenta una particularidad en la solución particular, esto es que dependiendo del orden en la que se encuentran los factores, al plantear la integral sucesiva aparentemente se encuentra dos soluciones de , que al comprobarlas en la ecuación diferencial si cumplen, esto lleva a pensar que no cumple con el teorema de Cauchy, el cual manifiesta que la ecuación diferencial tiene una única solución, pero al aplicar las condiciones iniciales en la solución general , esta si cumple con dicho teorema corroborándose que la ecuación diferencial ordinaria lineal de coeficientes constantes tiene solución única al resolverla por el método de integrales sucesivas. De esta manera el estudio entonces corrobora y comprueba que el teorema de Cauchy garantiza la existencia y unicidad de una solución que cumple con las condiciones iniciales de una ecuación diferencial ordinaria. Objetivo: Comprobar que la solución particular resuelta por integración sucesiva de una ecuación diferencial ordinaria lineal de coeficientes constantes conduce a una solución particular de la ecuación diferencial única. Metodología: En el presente estudio para la resolución de las ecuaciones deferenciales ordinarias lineales no homogéneas de coeficiente constantes se utiliza el método de integrales sucesivas, además de utilizar el criterio de comprobación de la solución de una ecuación diferencial, para determinar mediante el teorema de Cauchy, que la solución es única en una ecuación diferencial cuando se tiene condiciones iniciales específicas. Resultados: A partir de un caso específico cuando la parte no homogénea tiene la forma donde a es una raíz de la ecuación característica, aparentemente se encuentra dos soluciones para la solución particular, se comprueba que la solución es única al obtener la solución particular de la ecuación diferencial, con una condición inicial dada. Conclusión: Se comprueba que la solución particular resuelta por integración sucesiva de una ecuación diferencial ordinaria lineal de coeficientes constantes conduce a una solución particular de la ecuación diferencial única. Área de estudio general: análisis matemático. Área de estudio específica: ecuaciones diferenciales ordinarias lineales no homogéneas de coeficientes constantes.
ATENDIMENTO EDUCACIONAL ESPECIALIZADO: O QUE É E PARA QUEM?
Authors: Regert Rodrigo , Fernandes Raquel Martins , Baade Joel Haroldo , Frigotto Sabrina , Cabral Johann Cristiane , Da Costa Eslabão Leomar , Da Silva do Carmo Juçara 
Published: August 2023

Nos tempos hodiernos muito se tem falado sobre a Educação Inclusiva e Especial, como consequência, o Atendimento Educacional Especializado (AEE) vem ganhando grande notoriedade, mas o que é e para quem? Diante disso o objetivo deste artigo é elucidar o que é o AEE e qual o seu público-alvo. Quanto a metodologia a natureza do estudo é básica, sua abordagem é qualitativa e exploratória e o procedimento metodológico é bibliográfico. Por fim, conclui-se que o AEE é um atendimento feito por um professor especializado e na Sala de Recursos Multifuncional (SRM) que busca eliminar as barreiras de aprendizagem e tem como público-alvo específico os alunos com Deficiência, com Transtorno do Espectro Autista (TEA) e Alta Habilidades e/ou Superdotação, em suma, aqueles que por anos estiveram alijados de uma participação exitosa nas atividades escolares.
Palavras-chave: Educação Inclusiva. Educação Especial. Atendimento Educacional Especializado. Público-alvo.

ABSTRACT
In current times, much has been said about Inclusive and Special Education. As a result, Specialized Educational Assistance (SEA) has gained great prominence. But what is it, and who is it for? The objective of this article is to elucidate what SEA is and who its target audience is. Regarding the methodology, the nature of the study is basic, its approach is qualitative and exploratory, and the methodological procedure is bibliographic. In conclusion, SEA is an assistance provided by a specialized teacher in the Multifunctional Resource Room (MRR), aiming to eliminate learning barriers. Its specific target audience comprises students with disabilities, Autism Spectrum Disorder (ASD), and High Abilities and/or Giftedness, in short, those which, for years, were excluded from successful participation in school activities.
Keywords: Inclusive Education. Special Education. Specialized Educational Assistance. Target audience.
Relationship between cell envelope ultrastructure and the antibacterial properties of a novel hydrophobic eumelanin-inspired derivative
Authors: Reed Daniel R. , Nehmzow Katherine , Essandoh Martha A. , Ebqa'ai Mohammad A. , Nelson Toby L. , Lutter Erika I. , Cook Gabriel A. , Champlin Franklin R. 
Published: August 2023

IntroductionUnique impermeability properties of the gram-negative outer cell envelope typically render these organisms intrinsically resistant to hydrophobic antibacterial compounds. Eumelanin-inspired indoylenephenyleneethynylene (EIPE) compounds possess scaffolding to which functional groups were attached to potentially provide antibacterial properties in the forms of hydrophilic (EIPE-HCl) and hydrophobic (EIPE-1) derivatives.MethodsStandardized disk agar diffusion and microbroth dilution bioassays were employed to assess the susceptibility of disparate gram-negative and gram-positive bacterial pathogens to the two compounds. EIPE-1 mechanisms of action and intrinsic resistance were further investigated turbidimetrically in batch cultures with the aid of the gram-negative outer membrane permeabilizer compound 48/80.ResultsHydrophobic derivative EIPE-1 exhibited a gram-positive antibacterial spectrum, while hydrophilic derivative EIPE-HCl possessed no antibacterial properties. EIPE-1 exhibited minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values below 2.0 µg/mL against all gram-positive bacteria, including two methicillin-resistant strains. In contrast, MIC/MBC values greater than 128 µg/mL were obtained for all gram-negative bacteria examined. Susceptibility of two strains of the strict anaerobe Clostridioides difficile indicated the EIPE-1 mechanism of action does not require molecular oxygen. Turbidimetric growth curves revealed EIPE-1 induced rapid bacteriolysis of Bacillus subtilis ATCC 6633, thereby suggesting a membrane-directed modality. Lastly, the outer membrane permeabilizer compound 48/80 failed to markedly sensitize any of three phylogenetically disparate gram-negative organisms to EIPE-1.ConclusionThese data suggest that the hydrophobic melanin-inspired derivative EIPE-1 inhibits gram-positive bacteria in a cytoplasmic membrane-directed manner independent of oxygen. Moreover, a secondary mechanism may function concomitantly with outer membrane exclusionary properties to underly the intrinsic resistance of gram-negative pathogens.
Associations between long-term blood pressure trajectory and all-cause and CVD mortality among old people in China
Authors: Liu Huimeng , Wang Yutong , Zhang Binyan , Liu Jingchun , Huo Yating , Cao Suixia , Wu Shaowei , Wan Yong , Xie Xinming , Zeng Lingxia , Yan Hong , Dang Shaonong , Mi Baibing 
Published: August 2023

BackgroundOptimal blood pressure (BP) management strategy among the elderly remains controversial, with insufficient consideration of long-term BP trajectory. This study aimed to identify BP trajectory patterns as well as terminal BP trajectory among the Chinese elderly and to explore the relationships between BP trajectories and all-cause mortality and cardiovascular disease (CVD) mortality.MethodsWe included 11,181 participants older than 60 at baseline (mean age, 80.98 ± 10.71) with 42,871 routine BP measurements from the Chinese Longitudinal Healthy Longevity Survey. Latent class trajectory analysis and Cox proportional hazard model were conducted to identify trajectory patterns and their associations with mortality. Furthermore, we also applied mixed-effects model to identify terminal BP trajectories among the elderly.ResultsCompared with stable at normal high level trajectory, excess systolic BP (SBP) trajectory with decreasing trend was associated with a 34% (HR = 1.34, 95% CI: 1.23–1.45) higher risk of all-cause mortality. Considering the competing risk of non-CVD death, excess BP trajectory with decreasing trend had a more pronounced effect on CVD mortality, in which HR (95% CI) was 1.67 (1.17, 2.37). Similar results were also found in diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP) trajectories. We further conducted a mixed-effects model and observed that SBP and PP trajectories first increased and began to decline slightly six years before death. In contrast, DBP and MAP showed continuous decline 15 years before death.ConclusionLong-term BP trajectory was associated with all-cause mortality, especially CVD mortality. Keeping a stable BP over time may be an important way for CVD prevention among the elderly.
Efficacy and safety of Qixue Tongzhi Granule in improving the exercise capacity of stable coronary artery disease: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial
Authors: Chao Tiantian , Sun Jinghui , Huan Na , Ge Yaru , Wang Chenglong 
Published: August 2023

BackgroundDespite optimal medical therapy, patients with stable coronary artery disease (SCAD) still have a high risk of recurrent cardiovascular events. Exercise capacity measured by cardiopulmonary exercise testing (CPET) is a good surrogate marker for the long-term prognosis of SCAD. Qixue Tongzhi Granule (QTG) is created by academician Chen Keji and has the function of tonifying qi, promoting blood circulation, and regulating qi-flowing. This trial aims to investigate the efficacy and safety of QTG in improving exercise tolerance, alleviating angina pectoris and anxiety/depression symptoms, promoting health-related quality of life, and reducing the risk of adverse cardiovascular events in subjects with SCAD.MethodsThis is a randomized, double-blind, placebo-controlled trial. 150 SCAD patients with qi deficiency, blood stasis, and liver qi stagnation syndrome are enrolled. Patients will be randomly allocated to the QTG or placebo groups at a 1:1 ratio. QTG and placebo will be added to the modern guideline-directed medical therapy for 12 weeks and patients will be followed up for another 24 weeks. The primary outcome is the improvement of metabolic equivalents measured by CPET. The secondary outcomes are cumulative incidence of composite endpoint events, other indicators in CPET, changes in the Seattle Angina Questionnaire, traditional Chinese medicine syndrome scale, 12 items of Short Form Health Survey Questionnaire, Patient Health Questionnaire-9, and Generalized Anxiety Disorder-7, changes of ST-T segment in the electrocardiogram, improvement of left ventricular ejection fraction and left ventricular end-diastolic diameter in echocardiography. In addition, metabolomics analysis will be performed based on blood samples. Adverse events and safety evaluations will also be documented. A full analysis set, per protocol set, and safety analysis set will be conducted.DiscussionThis clinical trial can enrich treatment options for CHD patients with low cardiorespiratory fitness and psychological imbalance, and it may also create a new situation for promoting the application of traditional Chinese medicine in cardiac rehabilitation.Clinical Trial Registration: [http://www.chictr.org.cn], identifier: [ChiCTR2200058988].
Risk sharing in quasi-public-welfare water conservancy (PPP) public-private participation projects: an integrated application of Shapley value and utility theory
Authors: Liu Dawei , Liu Liang , Tan Xin 
Published: August 2023

Introduction: Quasi-public water conservancy PPP (Public-private participation) projects are closely related to people’s livelihoods and involve multiple participating stakeholders. Previous research on risk sharing in such projects has primarily focused on qualitative analysis of risk factors. Due to self-interest considerations, the collaborating parties tend to deflect and transfer risks to each other as much as possible in the risk sharing process. Additionally, some quantitative analysis methods have been predominantly based on a unilateral perspective.Methods: Therefore, the present study proposed a new model, which is based on the Shapley Value and the Utility Theory, encompassing a comprehensive analysis of multiple factors such as the proportion of capital contribution, bargaining position, risk management capabilities, and risk-taking willingness of heterogeneous subjects. Firstly, the relationship between the risk losses of different stakeholders and their corresponding value scales and utility attributes is comprehensively analysed, and the transformation characteristics and links of their risk preferences on spatial and temporal scales are summarised. Secondly, The utility values of heterogeneous subjects are employed as quantitative indicators to evaluate utility, leading to the construction of a comprehensive utility objective function for these subjects. Finally, The Shapley Value is then applied to modify the risk-sharing ratio based on the Utility Theory.Results: The research results show that the risk sharing ratio obtained by single use of shapley value theory or utility theory will be biased toward one side, while the result calculated by using the combination of the two methods is 57.35% for the government to share the risk ratio, and 42.65% for the social capital side, which is a more balanced result.Discussion: The proposed model enriches the risk management method and theory of quasi public welfare water conservancy PPP projects.
Radioactive iodine therapy strategies for distinct types of differentiated thyroid cancer: a propensity score–matched analysis
Authors: Guo Honghao , Zhang Ning , Hu Yixuan , Zhang Furong , Huang Tao , Shen Na 
Published: August 2023

BackgroundThe management guidelines of radioactive Iodine (RAI) therapy for distinct types of differentiated thyroid carcinoma (DTC) were the same in clinical practice. However, in distinct types DTC, differences in RAI avidity and response existed and the effect of RAI therapy could not be equated.MethodsDTC patients’ data in SEER database were extracted to perform retrospective analysis. The differences between case group and control group were compared by chi-square tests. We used Kaplan-Meier statistics and Cox regression analyses to investigate cancer-specific survival (CSS). Propensity score–matched was performed to make 1:1 case-control matching.Results105195 patients who receiving total thyroidectomy were identified in SEER database. Compared to papillary thyroid carcinoma (PTC) (52.3%), follicular thyroid carcinoma (FTC) (63.8%) and oncocytic carcinoma of thyroid (OCA) (64.4%) had higher rates of RAI therapy. In the multivariable Cox regression model, RAI therapy was independent prognosis factor in PTC but not in OCA and FTC. In subgroup analysis, RAI therapy could improve prognosis in PTC when gross extrathyroidal extension or lymph node metastases or early survival when distant metastases (DM) were presented. However, OCA and FTC patients with DM rather than regional lesions only could benefit from RAI therapy. High-risk patients receiving RAI therapy showed a better prognosis in PTC but not in OCA and FTC.ConclusionRAI therapy was an effective treatment for DTC and should be considered individually in PTC, OCA and FTC patients. Our results provided further guideline for treatment selection in DTC.
Anti-osteoporosis mechanism of resistance exercise in ovariectomized rats based on transcriptome analysis: a pilot study
Authors: Wang Qing , Weng Heng , Xu Yue , Ye Hui , Liang Yongqi , Wang Lulu , Zhang Yutong , Gao Yujie , Wang Jiayi , Xu Yuchen , Sun Zhiling , Xu Guihua 
Published: August 2023

Postmenopausal osteoporosis is the main cause of fractures in women. Resistance exercise has a positive effect on bone mineral density in postmenopausal osteoporosis patients, but its mechanism is unclear. The purpose of this study was to explore the mechanism of resistance exercise in improving ovariectomized osteoporotic rats based on the transcriptome sequencing technique. Eighteen female Sprague-Dawley rats were randomly divided into the sham-operated group, the non-exercise group, and the resistance exercise group. The rat model of postmenopausal osteoporosis was established by bilateral ovariectomy. Ten weeks after the operation, the resistance exercise group received 2 weeks of adaptive training, and 12 weeks of resistance exercise began in the 13th week. The rats were trained 5 days per week, in 4 sets of 3 repetitions per day. After the intervention, all rats were sacrificed, and the body weight, bone mineral density, trabecular bone microarchitecture, and bone biomechanics were examined. At the same time, RNA-seq and enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes were performed on the left tibias, followed by Elisa and RT-qPCR verification. It had been found that resistance exercise can effectively counteract the weight gain of ovariectomized osteoporotic rats, and has a good effect on bone mineral density and trabecular bone microarchitecture. Enrichment analysis showed that regulation of gene expression and osteoclast differentiation is the most closely related biological process and signaling pathway shared by RE/Ovx and NE/Ovx groups. Our results revealed that resistance exercise can play a role in inhibiting osteoclast activation and preventing the enhancement of osteoclast bone resorption function in ovariectomized osteoporotic rats by inhibiting Fos/Fosb-regulated TRAP activation and relieving Calcr inhibition, which has important application value in preventing bone loss caused by estrogen deficiency.