bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter
Authors: Schreiber Julian Alexander , Derksen Anastasia , Goerges Gunnar , Schütte Sven , Sörgel Jasmin , Kiper Aytug K. , Strutz-Seebohm Nathalie , Ruck Tobias , Meuth Sven G. , Decher Niels , Seebohm Guiscard 
Published: July 2023

AbstractThe TWIK-related spinal cord K+ channel (TRESK, K2P18.1) is a K2P channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiation rendering the channel a new pharmacological target for treatment of autoimmune diseases. The channel activator cloxyquin represents a promising lead compound for the development of a new class of immunomodulators. Identification of cloxyquin binding site and characterization of the molecular activation mechanism can foster the future drug development. Here, we identify the cloxyquin binding site at the M2/M4 interface by mutational scan and analyze the molecular mechanism of action by protein modeling as well as in silico and in vitro electrophysiology using different permeating ion species (K+ / Rb+). In combination with kinetic analyses of channel inactivation, our results suggest that cloxyquin allosterically stabilizes the inner selectivity filter facilitating the conduction process subsequently activating hTRESK.
Lampshade web spider Ectatosticta davidi chromosome-level genome assembly provides evidence for its phylogenetic position
Authors: Fan Zheng , Wang Lu-Yu , Xiao Lin , Tan Bing , Luo Bin , Ren Tian-Yu , Liu Ning , Zhang Zhi-Sheng , Bai Ming 
Published: July 2023

AbstractThe spider ofEctatosticta davidi, belonging to the lamp-shade web spider family, Hypochilidae, which is closely related to Hypochilidae and Filistatidae and recovered as sister of the rest Araneomorphs spiders. Here we show the final assembled genome ofE. davidiwith 2.16 Gb in 15 chromosomes. Then we confirm the evolutionary position of Hypochilidae. Moreover, we find that the GMC gene family exhibit high conservation throughout the evolution of true spiders. We also find that the MaSp genes ofE. davidimay represent an early stage of MaSp and MiSp genes in other true spiders, while CrSp shares a common origin with AgSp and PySp but differ from MaSp. Altogether, this study contributes to addressing the limited availability of genomic sequences from Hypochilidae spiders, and provides a valuable resource for investigating the genomic evolution of spiders.
Opportunities and challenges for sweat-based monitoring of metabolic syndrome via wearable technologies
Authors: Lyzwinski Lynnette , Elgendi Mohamed , Shokurov Alexander V. , Cuthbert Tyler J. , Ahmadizadeh Chakaveh , Menon Carlo 
Published: July 2023

AbstractMetabolic syndrome is a prevalent condition in adults over the age of 65 and is a risk factor for developing cardiovascular disease and type II diabetes. Thus, methods to track the condition, prevent complications and assess symptoms and risk factors are needed. Here we discuss sweat-based wearable technologies as a potential monitoring tool for patients with metabolic syndrome. We describe several key symptoms that can be evaluated that could employ sweat patches to assess inflammatory markers, glucose, sodium, and cortisol. We then discuss the challenges with material property, sensor integration, and sensor placement and provide feasible solutions to optimize them. Together with a list of recommendations, we propose a pathway toward successfully developing and implementing reliable sweat-based technologies to monitor metabolic syndrome.
Decomposition analysis on factors affecting electricity substitution in Guangdong province, China
Authors: Chen Haobo , Liu Shangyu , Kuang Yaoqiu , Wang Tonghe , Shu Jie , Ma Zetao 
Published: July 2023

AbstractElectricity substitution is an effective measure for reducing pollutant emissions and promoting the consumption of renewable energy. The current research lacks a quantitative analysis method for the factors affecting regional electricity substitution. This article proposes a decomposition model of the factors affecting electricity substitution based on Logarithmic Mean Divisia Index method to expand the depth and breadth of electricity substitution. Results show that: (1) Macro‐level electricity substitution in Guangdong province develops steadily, with 1694.93 × 108 kWh of total electricity substitution quantity during the period 2006–2020. The electricity substitution quantity in production sector accounts for 83.92% of the total, which is much larger than that in household sector. (2) Sustained improvement of labour productivity gives the largest contribution (3592.32 × 108 kWh) to the increase of electricity substitution in production sector during the period 2006–2020. Living standard effect has the largest contribution (452.21 × 108 kWh) to the increase of electricity substitution in household sector during the period 2006–2020. Electrification level effect and population effect have significant impact on electricity substitution development, while industrial structure has little impact on electricity substitution. (3) Energy intensity effect and energy consumption growth effect negatively influence electricity substitution in Guangdong province. The decline of energy intensity in the production sector has driven the decrease of electricity substitution quantity, contributing −2540.36 × 108 kWh to electricity substitution during the period 2006–2020. Policy implications like continuously promoting breakthroughs in electricity substitution technologies, improvement of electrification rate in the sectors with potential for substitution, and improvement the price mechanism for fossil fuels and electricity can promote the deepening development of electricity substitution and the realisation of the carbon neutrality goal.
A novel X‐band CMOS asymmetric T/R switch with high‐pass TX arm and low‐pass RX arm
Authors: Fu Jia‐Shiang 
Published: July 2023

AbstractIn this work, a novel asymmetric T/R switch is proposed. The operating principle and design equations of the proposed T/R switch topology are presented. Based on the proposed circuit topology, an X‐band asymmetric T/R switch is designed in 0.18‐µm CMOS. From 9 to 11 GHz, the measured isolation is higher than 32 dB and the measured insertion loss is less than 1.87 dB for the TX mode. At 10 GHz, the measured TX‐mode is higher than 36 dBm.
LGANet: Local and global attention are both you need for action recognition
Authors: Wang Hao , Zhao Bin , Zhang Wenjia , Liu Guohua 
Published: July 2023

AbstractDue to redundancy in the spatiotemporal neighborhood and the global dependency between video frames, video recognition remains a challenge. Some prior works have been mainly driven by 3D convolutional neural networks (CNNs) or 2D CNNs with a well‐designed module for temporal information. However, convolution‐based networks lack the capability to capture the global dependency due to the limited receptive field. Alternatively, transformer for video recognition is proposed to build long‐range dependency between frame patches. Nevertheless, most transformer‐based networks have significant computational costs because attention is calculated among all the tokens. Based on these observations, we propose an efficient network which we dub LGANet. Unlike conventional CNNs and transformers for video recognition, the LGANet can tackle both spatiotemporal redundancy and dependency by learning local and global token affinity in shallow and deep layers, respectively . Specifically, local attention is implemented in the shallow layers to reduce parameters and eliminate redundancy. In the deep layers, spatial‐wise and channel‐wise self‐attention are embedded to realize the global dependency of high‐level features. Moreover, several key designs are made in the multi‐head self‐attention (MSA) and feed‐forward network (FFN). Extensive experiments are conducted on the popular video benchmarks, such as Kinetics‐400, Something‐Something V1&V2. Without any bells and whistles, the LGANet achieves state‐of‐the‐art performance. The code will be released soon.
An efficient optimization algorithm for electric vehicle routing problem
Authors: Vani Batchu Veena , Kishan Dharavath , Ahmad Md Waseem , Reddy Ch Rama Prakasha 
Published: July 2023

AbstractThere has been a steady increase in the prevalence of electric vehicles (EVs) (electric cars) in the transportation industry. The limited range of EVs and the lack of charging facilities make it harder to gain widespread adoption of the EV service. Several optimisation algorithms for EV routes have not yet resolved the problems of trip time and travel cost. The study provides a Bat optimisation technique to reduce trip time and costs while taking into account customer service requests and EV charging schedules. Taking into account battery capacity, charging duration, and delivery/pickup needs, the suggested method may determine the optimal path to supercharger stations. To demonstrate its effectiveness, it is compared to other state‐of‐the‐art algorithms across a variety of benchmark cases.
The Endocrine Treatment Landscape for Patients with HR+ HER2− Early-stage Breast Cancer in Germany Before the Introduction of CDK4/6 Inhibitor Therapy – A Real-World
Analysis
Authors: Nabieva Naiba , Altmann Falk , Apel Klaus , Baerens Dirk-Toralf , Beha Michaela , Belau Antje , Busch Steffi , Guth Dagmar , Heinrich Georg , Kreiss-Sender Janine , Markmann Susanne , Olbermann Andreas , Oskay-Özcelik Gülten , Schuback Beatrix , Steinfeld-Birg Dieter , Quiering Claudia , Kiss Ferenc , Kreuzeder Julia , Nuti Paolo , Schilling Jörg 
Published: July 2023

AbstractWhile premenopausal patients with HR+ HER2− early breast cancer are treated with tamoxifen +/− ovarian suppression with a GnRH analog or an aromatase inhibitor (AI) + GnRH, the majority
of postmenopausal women receive an AI due to its higher efficacy compared to tamoxifen. As the introduction of CDK4/6 inhibitors into the treatment of early-stage breast cancer with a
higher risk of recurrence will probably result in a shift in the endocrine treatment landscape, the question is what treatment did potential candidates for CDK4/6 inhibitors in Germany
receive before CDK4/6 inhibitors were available.As part of a retrospective multicenter analysis, anonymized data were collected of patients with HR+ HER2− early-stage breast cancer who received endocrine therapy in the period between
10/2021 and 03/2022. Potential candidates for CDK4/6 inhibitor treatment were classified into different risk cohorts using the inclusion criteria of the NATALEE and monarchE trials.The data of 238 patients from 29 different centers were analyzed. While 20.6% of patients met the monarchE criteria, the subgroup which met the NATALEE inclusion criteria consisted of
46.2% of patients. 53.8% of patients did not meet the inclusion criteria for either the NATALEE or the monarchE trial. More than half of the patients did not receive chemotherapy. 28.6% of
patients in the whole cohort were premenopausal. 67.6% of premenopausal women received neo-/adjuvant chemotherapy. 61.8% of premenopausal patients received tamoxifen as adjuvant endocrine
therapy, 19.1% received an AI + GnRH and 10.3% were treated with tamoxifen + GnRH.Despite the high percentage of premenopausal patients who received aggressive treatment in the form of chemotherapy, only one third of premenopausal patients received GnRH in addition to
their standard endocrine therapy. Studies carried out at a later point in time and registry studies will be necessary to see how the endocrine therapy landscape in Germany has changed
following the introduction of CDK4/6 inhibitors.
Recent Uses of Photogenerated Oxygen-Centered Radicals in Intermolecular C–O Bond Formation
Authors: Dagousset Guillaume , Banoun Camille , Magnier Emmanuel 
Published: July 2023

AbstractWe report herein recent advances made by our group and others in the field of oxygen-centered radicals generated under photocatalysis. Thanks to the design of new O-radical precursors, these radicals can now be efficiently trapped by unsaturated systems in an intermolecular manner, via the formation of a new C–O bond.1	Introduction2	Reactions Involving Carbonyloxy Radicals3	Reactions Involving Fluoroalkoxy Radicals4	Reactions Involving Alkoxy Radicals5	Conclusion
Implanting Impella 5.5 under Local Anesthesia
Authors: Eghbalzadeh Kaveh , Wahlers Thorsten C.W. , Deppe Antje Christin 
Published: July 2023

Abstract
Background Surgically implanted Impella 5.5. delivers full cardiac support and left ventricular unloading for patients with heart failure. So far, the Impella device is implanted under general anesthesia (GA).
Material and Methods A total of n = 3 critically ill patients presented with acute heart failure in need of cardiac support. All patients suffered cardiogenic shock of varying etiology. Due to hemodynamically unstable conditions, GA was avoided. All implantations were performed solely under local anesthesia (LAS) without any regional anesthesia.
Results All implantations were performed successfully under LAS with 60 mL of mepivacaine of 2% solution and ropivacaine of 1% solution (50:50 ratio). All devices were placed from the right axillary artery. One patient needed hematoma evacuation several days after surgery. No other Impella-related complication was observed.
Conclusion A surgical implantation of the Impella 5.5 device under LAS is feasible and safe. Despite the small number of cases, no disadvantage can be described at the present moment. Our series should encourage physicians to perform the procedure under LAS.
Refining Clinician Workflow as a Means to Improving Catheter Quality Measures
Authors: Clarke Martina A. , Wardian Jana L. , Fleharty Brandon S. , Reha Craig G. , Birge Justin R. 
Published: July 2023

Abstract
Objective This study aimed to improve the quality measure performance for indwelling urinary catheter (IUC) duration, central venous catheter (CVC) duration, and telemetry duration by redesigning clinical decision support (CDS) tools within the documentation process and order workflow.
Methods The effectiveness of the redesign was evaluated using system standard quality reporting methodology to observe device duration, central-line-associated bloodstream infection (CLABSI) rate, and catheter-associated urinary tract infection (CAUTI) rate preintervention (FY2017) and postintervention (FY2018). Electronic health record (EHR) reporting tools were used to evaluate CDS alert data both preintervention and postintervention.
Results Total device duration and line days per patient days were reduced for CVC (12.8% [0.305–0.266]) and IUC (4.68% [0.171–0.163]). Mean telemetry duration was reduced by 16.94% (3.72–3.09 days), and CDS alert volume decreased 18.6% from a preintervention mean of 1.18 alerts per patient per day (81,190 total alerts) to a postintervention mean of 0.96 alerts per patient per day (61,899 total alerts). Both CLABSI (2.8% [1.07–1.04]) and CAUTI (8.1% [1.61–1.48]) rates were reduced, resulting in approximately $926,000 in savings.
Conclusion In this novel model, the redesigned CDS tools improved clinician response to CDS alerts, prompting providers to take action on relevant orders that automatically updated the clinical documentation to reflect their actions. The study demonstrated that effective redesign of CDS tools within the documentation process and order workflow can reduce device duration, improve patient outcomes, and decrease CDS alert volume.
Risk spillover in China’s real estate industry chain: a DCC-EGARCH-ΔCoVaR model
Authors: Chen Xiaoyang , Zhou Liguo , Wang Lin , Zheng Yuelong 
Published: July 2023

Abstract
Real estate’s role in the financial crisis has forced central banks and academics to focus on the real estate risk’s spillover effects. However, findings on this matter are erratic and could differ from country to country. Prior research mostly ignored risk contagion at the level of the real industry and instead concentrated on real estate and financial institutions. Therefore, to analyze the risk spillover of China’s real estate industry from a novel perspective of the industrial chain, a mixed model (DCC-EGARCH-CoVaR model) is proposed in this work. It fixes the flaw in existing models’ inability to account for asymmetries and the weakness of traditional methods in explaining the time-varying and nonlinear risk infection process. The findings demonstrate that China’s real estate industry has a noticeable risk spillover effect on upstream and downstream industries. The downstream industry is the one most affected by risk spillover from the real estate sector, followed by the upstream industry, and the banking sector is the least affected. The risk spillover effects of macro uncertainties like the COVID-19 outbreak, the financial crisis, and the stock market fall on real estate vary significantly. These findings are helpful for regulators to prevent systematic financial risks and for institutional investors to make timely strategic asset allocations and adjustments.
Methods of controlled formation of instabilities during the electrical explosion of thin foils
Authors: Shelkovenko T. A. , Tilikin I. N. , Oginov A. V. , Mingaleev A. R. , Romanova V. M. , Pikuz S. A. 
Published: July 2023

The results of a study of the electrical explosion of aluminum foils with an artificial periodic surface structure created by laser engraving are presented. Experiments were carried out on pulsed high-current generators BIN (270 kA, 300 kV, 100 ns) and KING (200 kA, 40 kV, 200 ns) with Al foil of thicknesses 16 and 4 μm, respectively. Images of the exploded foils were recorded by point projection radiography in the radiation from hybrid X-pinches. It is found that the application of an artificial periodic structure to the foil leads to a much more uniform and well-defined periodic structure of the exploded foil. Images recorded in the UV range using a microchannel-plate-intensified detector show that the radiation from a surface-modified foil is more uniform along the entire length and width of the foil than that from a foil without modification.
Scalable wavelength-multiplexing photonic reservoir computing
Authors: Li Rui-Qian , Shen Yi-Wei , Lin Bao-De , Yu Jingyi , He Xuming , Wang Cheng 
Published: July 2023

Photonic reservoir computing (PRC) is a special hardware recurrent neural network, which is featured with fast training speed and low training cost. This work shows a wavelength-multiplexing PRC architecture, taking advantage of the numerous longitudinal modes in a Fabry–Perot (FP) semiconductor laser. These modes construct connected physical neurons in parallel, while an optical feedback loop provides interactive virtual neurons in series. We experimentally demonstrate a four-channel wavelength-multiplexing PRC architecture with a total of 80 neurons. The clock rate of the multiplexing PRC reaches as high as 1.0 GHz, which is four times higher than that of the single-channel case. In addition, it is proved that the multiplexing PRC exhibits a superior performance on the task of signal equalization in an optical fiber communication link. This improved performance is owing to the rich neuron interconnections both in parallel and in series. In particular, this scheme is highly scalable owing to the rich mode resources in FP lasers.
Dynamic changes and importance of plasma concentrations of ether phospholipids, of which the majority are plasmalogens, in postpartum Holstein dairy cows
Authors: Saito Risa , Kubo Tomoaki , Wakatsuki Takuji , Asato Yuuki , Tanigawa Tamako , Kotaniguchi Miyako , Hashimoto Maki , Kitamura Shinichi , Kadokawa Hiroya 
Published: July 2023

Context Ethanolamine plasmalogens (EPls) and choline plasmalogens (CPls) are classes of ethanolamine ether phospholipids (ePE) and choline ether phospholipids (ePC), respectively. EPls play crucial roles in maternal and breastfed infant bodies and stimulate gonadotropin secretion by gonadotrophs. Aims To estimate changes in and importance of plasma concentrations of EPls and CPls, utilising newly developed enzymatic fluorometric assays for ePE and ePC in postpartum Holstein cows. Methods Plasma samples were collected from 3 weeks before expected parturition until approximately 8 weeks after parturition (16 primiparous and 38 multiparous cows) for analysis. Key results Plasma concentrations of ePE and ePC, most of which are plasmalogens, declined before and increased after parturition and stabilised near the day of the first postpartum ovulation (1stOV). From weeks 2 to 3 after parturition, third-parity cows exhibited ePE concentrations that were higher than those of other parity cows. The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with plasma concentration of both ePE and ePC, while ePC concentration correlated negatively with milk fat percentage. At the early luteal phase after 1stOV, plasma ePE concentration correlated with plasma anti-Müllerian hormone concentration (r = 0.39, P < 0.01), and plasma ePC concentration correlated with plasma follicle-stimulating hormone concentration (r = 0.43, P < 0.01). Conclusion The concentrations of ePE and ePC changed dramatically around parturition and 1stOV, and the concentrations correlated with important parameters for milk production and reproduction. Implications The blood plasmalogen may play important roles in postpartum dairy cows.
Magnetic anisotropy and planar topological Hall effect in SrMn
x
Ir1−
x
O3 films
Authors: Hou Pengxiang , Li Yao , Liu Zhiyu , Zhang Chenyu , Han Yajie , Xi Zhongnan , Li Jiayi , Li Man-Rong , Deng Yu , Yang Yurong , Hu Yong , Wu Di 
Published: July 2023

Abstract
Strong Coulomb repulsion and spin–orbit coupling are known to give rise to exotic physical phenomena in transition metal oxides. Here, we report magnetic and transport characteristics of (001) oriented epitaxial SrMn
x
Ir1−x
O3 thin films, having both 3d and 5d elements on the perovskite B sites. With the increase of Mn concentration, perpendicular magnetic anisotropy (PMA) decreases gradually in accompany with the magnetic easy axis tilting away from the out-of-plane [001] direction. X-ray absorption spectroscopy reveals that Mn e
g electrons preferentially occupy the

d

3

z

2

−

r

2

orbital, which produces the observed PMA in the framework of spin-orbital coupling. A planar topological Hall effect appears in SrMn
x
Ir1−x
O3 films with x about 0.30 when the magnetic field is applied along the current, which is a result of the noncoplanar spin structure due to the competition among the PMA, the magnetic exchange interaction and the Zeeman energy. These results provide an example to show the subtle balance among complex competitions in materials with both strong correlation and spin-orbit coupling.
Federated domain generalization with global robust model aggregation strategy for bearing fault diagnosis
Authors: Cong Xiao , Song Yan , Li Yibin , Jia Lei 
Published: July 2023

AbstractFederated learning ensures the privacy of fault diagnosis by maintaining a decentralized and local training data approach, eliminating the need to share confidential information with a central server. However, the performance of trained models tends to significantly deteriorate when applied to completely unseen domains. To address this challenge, this paper introduces a novel method called federated domain generalization with a global robust model aggregation strategy. Our proposed method can collaboratively train a model with outstanding generalization ability and robustness to unseen target domains in a data-protecting way. Specifically, a maximum mean discrepancy is introduced in the central server to reduce the discrepancy of features from different source clients. Meanwhile, classification loss across source domains is designed as the weights for local model aggregation in the central server. Finally, experimental results under two different bearing fault datasets show that our method obtains higher classification accuracy than other compared methods, which demonstrates that the proposed method has better generalization ability and is promising in real industrial applications.