bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Implementasi “Aku Sayang Lingkungan” Anak-Anak Usia Dini pada kegiatan Sanitary Camp di PAUD Ummi Rodiah di Kampung Pangan Inovatif, Palembang
Authors: Najmah Najmah , Azizah Shinta , Iqlima Erni , Rachmawati Aisyah , Putrisha Shantya Adeline , Khoirunnisa Salsabila , Hanifah Arindi Dinda , Elwin Ghani El Mughni Muhammad Hidayatullah , Utama Feranita , Idris Haerawati , Arinda Ditia Fitri , Trisnaini Inoy , Misnaniarti Misnaniarti , Indahsari Siti Rahmi , Suhendra Ahmad Adi , Mufarika Rully 
Published: July 2023

Manusia dan lingkungan memiliki hubungan yang saling berkorelasi dan tidak dapat dipisahkan, perilaku pencemaran dan perusakan lingkungan yang dilakukan manusia akan menyebabkan lingkungan menjadi rusak dan tercemar dan akhirnya akan berakibat buruk bagi manusia itu sendiri. Hal tersebut menunjukkan bahwa perubahan perilaku manusia terhadap lingkungan adalah jalan satu-satunya dalam perbaikan lingkungan. Kepedulian dan kecintaan terhadap lingkungan sudah seharusnya ditanamkan pada anak sejak dini karena anak-anak dan anak merupakan subjek otonom yang mempunyai benih karakter sejak awal dari kehidupannya. Tujuan pengabdian ini adalah pendidikan lingkungan kepada anak-anak, sehingga anak-anak sadar dan mau untuk bertanggung jawab menjaga lingkungan dan membentuk sikap dalam pelestarian lingkungan serta kemampuan untuk memecahkan masalah lingkungan. Metode pengabdian yang dilakukan pada kegiatan ini yaitu dengan penyampaian materi pembelajaran interaktif dengan mengadakan pertemuan secara langsung dengan bersama anak-anak di Paud Ummi Rodiah, Plaju. Responden pada penelitian ini adalah anak-anak usia dini dari Paud Ummi Rodiah, Plaju dan anak-anak Sekolah Dasar di sekitar Paud Ummi Rodiah yang berjumlah 52 orang. Konsep yang diterapkan pada kegiatan ini adalah belajar sambil bermain dengan upaya edukasi mengenai Perilaku Hidup Bersih dan Sehat (PHBS), isi piringku, cara menjaga kebersihan dan kesehatan lingkungan, memilah sampah, hingga mengenal dan menanam Tanaman Obat Keluarga (TOGA). Hasil dari pengabdian ini dengan melibatkan guru-guru, Dosen dan mahasiswa Fakultas Kesehatan Masyarakat Universitas Sriwijaya sebagai Volunteers. Anak–anak mampu mengenal terhadap lingkungan dan secara tidak langsung memberikan pendidikan kepada anak–anak tentang pentingnya menjaga kebersihan lingkungan dapat membuat anak bersikap dan berperilaku cinta terhadap lingkungan dengan menjaga kebersihan lingkungan. Dengan diadakannya kegiatan pengabdian masyarakat ini, diharapkan perlunya tanggapan serius dari berbagai semua pihak untuk peduli dalam mencegah kerusakan lingkungan yang lebih berat untuk keberlangsungan hidup seluruh manusia.
Clinical-epidemiological Behavior of Oral Cancer in the Province of Guantanamo, 2007 - 2018
Authors: Pérez Delgado Nuria , Urgellés Rodríguez Eduardo , González Torres Lisandra 
Published: July 2023

Introduction: Oral cancer is a health problem that affects a significant group of people. Objective: To identify the clinical-epidemiological behavior of oral cancer in the province of Guantanamo in the period of 2007 - 2018. Method: A descriptive and cross-sectional study was carried out. The sample consists of 252 patients diagnosed with this disease by histopathology. The following variables were studied: triennial involvement, age, sex, origin, oral topography, clinical extension and morphological type. Results: The highest percentage of patients were male (69.4%), over 60 years of age (69.8%), from the municipality of Guantánamo (42.9%). The lesions were located mainly in the tongue (37.3%) and floor of the mouth (19.0%) and extended to the oral complex. Squamous cell carcinoma was the most common histopathological type (94%). Conclusions: In Guantanamo, oral cancer is an unsolved health problem that mainly affects the geriatric population and the male sex, which requires attention in advanced stages of the disease.
Perempuan berdaya melawan korupsi: Studi kasus kader Posyandu Desa Rumpin dalam menyikapi politik uang
Authors: Ramadhianty Mentari Anjhanie , Sadikin Usep Hasan , Argama Rizky 
Published: July 2023

Sebagai kelompok rentan dengan jumlah pemilih yang lebih besar dari lelaki, perempuan dijadikan objek suara dan politik uang pada Pemilu 2019 dan Pilkada 2020. Kerentanan bertambah karena KUHP dan Undang-Undang Pilkada menghukum pidana pemberi dan penerima politik uang. Penelitian yang dilakukan pada Kader Posyandu Durian Desa Rumpin, Kecamatan Rumpin, Kabupaten Bogor, Jawa Barat ini menunjukan keberdayaan perempuan dalam bentuk peningkatan kesadaran dan membangun relasi yang mampu menyesuaikan hegemoni dan struktur patriarki dalam politik uang. Semua kader p osyandu pernah mengalami politik uang tapi berdasar kesadaran dan bangunan relasi antar perempuan, pemberian uang tunai, barang, atau fasilitas publik dari oknum partai politik atau tim sukses tidak bisa mempengaruhi pilihan politik perempuan. Di tengah sistem pemilu proporsional daftar terbuka dan sistem kepartaian multipartai ekstrim yang secara sistemik menyuburkan praktik politik uang, peningkatan keberdayaan perempuan perlu dilakukan untuk mengubah politik uang menjadi transaksi politik ideologis dan visioner berdasarkan aspirasi dan kebijakan pemenuhan hak warga negara.
Consumo de tabaco, alcohol y otras sustancias y su relación con predictores de riesgo para la salud mental, en estudiantes del área de la salud. Medellín – Colombia.
Authors: Zuleta Vanegas Lina María , Toro Ocampo Jaime Horacio , Zapata Gómez Nora Eugenia 
Published: July 2023

Objetivo: Describir la prevalencia de consumo de tabaco, alcohol y otras sustancias y su relación con predictores de riesgo para salud mental en estudiantes de salud de una universidad publica Metodología: cuantitativa, descriptiva, trasversal. Se seleccionaron 3020 estudiantes de 9 facultades de salud. Muestreo por conglomerados proporcional al número de estudiantes por facultad, se utilizó cuestionario compuesto por cuatro partes: una con variables sociodemográficas y tres test. Resultados: AUDIT: de 1726 que respondieron, (80,4%) está en la zona de riesgo I donde se sugiere Educación sobre el alcohol, el 0,9% se ubicó en zona IV, derivación a especialista; FAGESTRÖM: los que respondieron (n=196), (88,3%) puntuaron como fumador poco dependiente; (8,2%) presentaron riesgo de dependencia; DUSI: con relación al consumo de sustancias ilícitas, la marihuana tiene el consumo más alto (n=554), (72.3%) fue experimental, (8.5%) lo realizon de forma compulsiva. Conclusión: Los datos encontrados permitieron ver cifras elevadas de consumo perjudicial, por tal motivo es necesario proponer estrategias de intervención oportunas.
Infección respiratoria en el paciente oncológico pediátrico en un hospital de alta complejidad en Medellín
Authors: Pineda Higuita Sonia Elena , Mendoza Pinzón Blanca Ros Mary 
Published: July 2023

Introducción. La mayoría de los casos de cáncer infantil se producen en América Latina y el Caribe, la principal localización es hematolinfoide, el paciente oncológico pediátrico tiene mayor riesgo de infecciones respiratorias de etiología múltiple. Objetivo. Determinar las infecciones respiratorias en el paciente oncológico pediátrico en un Hospital de alta complejidad de la ciudad de Medellín 2014-2016. Metodología. Estudio descriptivo, retrospectivo en el cual se evaluaron las historias clínicas de pacientes con diagnóstico de leucemia y tumores sólidos, internados en el Hospital General de Medellín, 2014 - 2016. Se realizó un análisis descriptivo y bivariado. Esta investigación conto con aval del comité de Ética institucional. Resultados. Se evaluaron 21 historias clínicas en las cuales se encontró que el 57,1% correspondió a la infección respiratoria del tracto inferior presentándose como neumonía en un 42,85%, derrame pleural, traqueítis y bronquitis todos estos con un 4,76%, la infección respiratoria alta se presentó en un 42,8% como rinofaringitis. El tipo de diagnóstico con mayor porcentaje fue la leucemia linfoide aguda con un 52,38%. Conclusión. La infección respiratoria baja, como la neumonía continúa siendo causa de morbimortalidad en el niño con cáncer, y más frecuente en la leucemia linfoide aguda con neutropenia.
Educomunicación digital: preferencias en el consumo de contenidos de las redes sociales de los estudiantes universitarios de Riobamba
Authors: Viñan Carrasco Luis , Murillo Naranjo Myriam , Erazo Rodríguez Miriam , Josefina Liccioni Edith 
Published: July 2023

Introducción: actualmente las interacciones sociales están presentes en las diferentes plataformas digitales, los usuarios de internet tienen la posibilidad de consumir distintos tipos de contenidos en las redes sociales. Pero este fenómeno digital también implica identificar las alternativas de consumo de información para reconocer la veracidad de los textos, imágenes o videos. Debido a la heterogeneidad que envuelve al usuario en entornos digitales, los límites en sus acciones, sobre todo en el consumo de contenidos no tienen los límites adecuados, consumen información para satisfacer sus necesidades sociales, de entretenimiento, en muy pocas ocasiones se revisa la veracidad del contenido, y no se toman en cuenta las medidas necesarias para verificar la veracidad del contenido que comparten. Objetivos: el objetivo de esta investigación es analizar qué factores influyen en el consumo de contenidos de las redes sociales por parte de los estudiantes universitarios de la ciudad de Riobamba. Metodología: el estudio tiene un enfoque cuantitativo, diseño no experimental, de tipo descriptivo de campo. La técnica utilizada fue la encuesta, con un cuestionario integrado por 31 ítems, como instrumento. La población está integrada por los estudiantes universitarios de la ciudad de Riobamba. Resultados: en los resultados obtenidos de la sección general se observa que un alto porcentaje de uso de las redes sociales, eligen los contenidos de entretenimiento, pero con menor preferencia los contenidos informativos y educativos. Conclusiones: en los factores positivos se observa la relevancia del consumo de la información respecto a problemas que afectan al Ecuador y del mundo. En los factores negativos se observa la presencia de información falsa en las redes sociales, el sensacionalismo, la saturación de información y el acoso. Se evidencia que los factores positivos son más relevantes que los factores negativos para los estudiantes universitarios y se recomienda la educomunicación en las aulas para fortalecer el consumo responsable. Área de estudio general: Comunicación. Área de estudio específica: Comunicación digital.
PEMBELAJARAN PROSES MENCIPTA TARI BAGI GURU MGMP SENI BUDAYA DI TINGKAT SMA DI KOTA DENPASAR
Authors: Mudiasih Ni Wayan , Iriani Ni Wayan , Widyarto Rinto 
Published: July 2023

Abstrak: Para guru seni budaya SMAN di Denpasar belum sepenuhnya memahami dan mengetahui tentang penciptaan baik teori dan praktek, sehingga banyak para siswa saat mendapat tugas tersebut harus mencari guru pelatih diluar sekolah dan harus membayarnya. Fenomena ini penting diantisipasi dan dicarikan solusinya, agar eksistensi penciptaan tari dapat dilakukan dengan mudah. Untuk itu perlu pembelajaran kelompok Guru Seni Budaya dalam Musyawarah Guru Mata Pelajaran (MGMP). Hal ini agar dapat mempermudah proses mencipta tari dan mampu memberikan pembelajaran teori dan praktek mencipta tari kreasi baru/kontemporer.Metode dekriptif dan pelaksanaannya menggunakan metode eksperimen imitasi, matematika, karakter dan transisi. Guru seni budaya ini diberikan pembelajaran langsung untuk mencipta tari yang selanjutnya dapat memberikan pembelajaran kepada peserta didik tingkat SMA, agar dapat meningkatkan kemampuan mencipta tari. Pembelajaran ini disambut antusias oleh segenap peserta dan menghasilkan 2 model karya tari kreasi dan kontemporer.
Kata Kunci:Pembelajaran, Mencipta, Tari, dan MGMP
Resource availability governs polyhydroxyalkanoate (PHA) accumulation and diversity of methanotrophic enrichments from wetlands
Authors: Kim Yujin , Flinkstrom Zachary , Candry Pieter , Winkler Mari-Karoliina H. , Myung Jaewook 
Published: July 2023

Aquatic environments account for half of global CH4 emissions, with freshwater wetlands being the most significant contributors. These CH4 fluxes can be partially offset by aerobic CH4 oxidation driven by methanotrophs. Additionally, some methanotrophs can convert CH4 into polyhydroxyalkanoate (PHA), an energy storage molecule as well as a promising bioplastic polymer. In this study, we investigate how PHA-accumulating methanotrophic communities enriched from wetlands were shaped by varying resource availability (i.e., C and N concentrations) at a fixed C/N ratio. Cell yields, PHA accumulation, and community composition were evaluated in high (20% CH4 and 10 mM NH4+) and low resource (0.2% CH4 and 0.1 mM NH4+) conditions simulating engineered and environmental settings, respectively. High resource availability decreased C-based cell yields, while N-based cell yields remained stable, suggesting nutrient exchange patterns differed between methanotrophic communities at different resource concentrations. PHA accumulation was only observed in high resource enrichments, producing approximately 12.6% ± 2.4% (m/m) PHA, while PHA in low resource enrichments remained below detection. High resource enrichments were dominated by Methylocystis methanotrophs, while low resource enrichments remained significantly more diverse and contained only a minor population of methanotrophs. This study demonstrates that resource concentration shapes PHA-accumulating methanotrophic communities. Together, this provides useful information to leverage such communities in engineering settings as well as to begin understanding their role in the environment.
Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1
Authors: Shen Liping , Jiang Shan , Yang Yu , Yang Hongli , Fang Yanchun , Tang Meng , Zhu Rangteng , Xu Jiaqin , Jiang Hantao 
Published: July 2023

Background: Overexpression of the NAD(P)H: Quinone Oxidoreductase 1 (NQOI) gene has been linked with tumor progression, aggressiveness, drug resistance, and poor patient prognosis. Most research has described the biological function of the NQO1 in certain types and limited samples, but a comprehensive understanding of the NQO1’s function and clinical importance at the pan-cancer level is scarce. More research is needed to understand the role of NQO1 in tumor infiltration, and immune checkpoint inhibitors in various cancers are needed.Methods: The NQO1 expression data for 33 types of pan-cancer and their association with the prognosis, pathologic stage, gender, immune cell infiltration, the tumor mutation burden, microsatellite instability, immune checkpoints, enrichment pathways, and the half-maximal inhibitory concentration (IC50) were downloaded from public databases.Results: Our findings indicate that the NQO1 gene was significantly upregulated in most cancer types. The Cox regression analysis showed that overexpression of the NQO1 gene was related to poor OS in Glioma, uveal melanoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma, and adrenocortical carcinoma. NQO1 mRNA expression positively correlated with infiltrating immune cells and checkpoint molecule levels. The single-cell analysis revealed a potential relationship between the NQO1 mRNA expression levels and the infiltration of immune cells and stromal cells in bladder urothelial carcinoma, invasive breast carcinoma, and colorectal cancer. Conversely, a negative association was noted between various drugs (17-AAG, Lapatinib, Trametinib, PD-0325901) and the NQO1 mRNA expression levels.Conclusion: NQO1 expression was significantly associated with prognosis, immune infiltrates, and drug resistance in multiple cancer types. The inhibition of the NQO1-dependent signaling pathways may provide a promising strategy for developing new cancer-targeted therapies.
Development and validation of prediction models for the prognosis of colon cancer with lung metastases: a population-based cohort study
Authors: Ma Zhenyu , Yang Shuping , Yang Yalin , Luo Jingran , Zhou Yixiao , Yang Huiyong 
Published: July 2023

BackgroundCurrent studies on the establishment of prognostic models for colon cancer with lung metastasis (CCLM) were lacking. This study aimed to construct and validate prediction models of overall survival (OS) and cancer-specific survival (CSS) probability in CCLM patients.MethodData on 1,284 patients with CCLM were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly assigned with 7:3 (stratified by survival time) to a development set and a validation set on the basis of computer-calculated random numbers. After screening the predictors by the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression, the suitable predictors were entered into Cox proportional hazard models to build prediction models. Calibration curves, concordance index (C-index), time-dependent receiver operating characteristic (ROC) curves, and decision curve analysis (DCA) were used to perform the validation of models. Based on model-predicted risk scores, patients were divided into low-risk and high-risk groups. The Kaplan–Meier (K-M) plots and log-rank test were applied to perform survival analysis between the two groups.ResultsBuilding upon the LASSO and multivariate Cox regression, six variables were significantly associated with OS and CSS (i.e., tumor grade, AJCC T stage, AJCC N stage, chemotherapy, CEA, liver metastasis). In development, validation, and expanded testing sets, AUCs and C-indexes of the OS and CSS prediction models were all greater than or near 0.7, which indicated excellent predictability of models. On the whole, the calibration curves coincided with the diagonal in two models. DCA indicated that the models had higher clinical benefit than any single risk factor. Survival analysis results showed that the prognosis was worse in the high-risk group than in the low-risk group, which suggested that the models had significant discrimination for patients with different prognoses.ConclusionAfter verification, our prediction models of CCLM are reliable and can predict the OS and CSS of CCLM patients in the next 1, 3, and 5 years, providing valuable guidance for clinical prognosis estimation and individualized administration of patients with CCLM.
Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics
Authors: Duan Jiajia , Liu Chuanxin , Bai Xiaoyang , Zhao Xiaoying , Jiang Tao 
Published: July 2023

BackgroundToxicity concerns persist in the fields of public health, environmental science, and pharmacology. The intricate and vital role of the gastrointestinal microbiome in influencing toxicity and overall human health has gained increasing recognition in recent years. This study presents a comprehensive bibliometric analysis to evaluate the global scientific output, emerging trends, and research focal points in the area of gastrointestinal microbiome and toxicity.MethodsThe Web of Science Core Collection database was retrieved for publications on the gastrointestinal microbiome and toxicity from 1980 to 2022. Our analysis included scholarly research papers written in English and excluded duplicate publications. We used Biblioshiny and R to summarize the count and citation metrics of included articles, and visualized research trends and keywords. CiteSpace was used to identify reference literature, keywords, and citation bursts. VOSviewer was used to visualize the network of related countries, institutions, authors, co-cited authors, and keywords.ResultsA total of 2,140 articles were included, allowing us to identify significant countries, institutions, authors, and research focal points. Our results indicate a growing trend in the field, with China and the United States leading the research. The most productive journal in this area is Science of the Total Environment. Key findings revealed that research hotspots have shifted from drugs to environmental pollutants, emphasizing microplastics. Important mechanisms studied include oxidative stress, metabolism, inflammation, and apoptosis, with target organs being the gastrointestinal tract, liver, and brain. Furthermore, we highlight the rising significance of the gut-brain axis and the usage of zebrafish as a model organism.ConclusionDespite certain limitations, such as focusing solely on English-language publications and excluding unpublished literature, our findings provide valuable insights into the current state of research on toxicity and the gastrointestinal microbiome. In the future, modifications to the gastrointestinal microbiome could offer new directions for treating and mitigating toxicity. These discoveries provide a comprehensive perspective on the broader scope of this research field.
Segmented filamentous bacteria-based treatment to elicit protection against Enterobacteriaceae in Layer chickens
Authors: Meinen-Jochum Jared , Ott Logan C. , Mellata Melha 
Published: July 2023

IntroductionGut microbes like segmented filamentous bacteria (SFB) play a key role in gut maturation during early life, as demonstrated in humans and mice. Our previous study demonstrated oral inoculation of ileum-spores containing SFB to chickens after hatch increases early SFB gut colonization, which increases immune maturation and resistance to bacteria, like Salmonella, as tested in vitro; however, more studies are needed for treatment optimization and in vivo testing. The objectives of this study were to (1) test a treatment that includes both spores and filamentous SFB, (2) validate antimicrobial ability of the treatment in layer hens in vivo, and (3) elucidate its molecular mechanism.MethodsOne-day-old specific pathogen-free layers (n = 12 per group) were orally treated with either PBS (CON) or SFB-based treatment (SFB). At 4 days post-inoculation (DPI), both CON and SFB groups were orally challenged with Salmonella Typhimurium. Total Enterobacteriaceae and Salmonella were examined by plating and enumeration in feces at 7,10 and 14 dpi; and in the ileum, cecum, and spleen at 16 dpi in euthanized birds. The presence and levels of SFB were determined from ilea scrapings via microscopy and qPCR, respectively. Relative gene expression of host-derived antimicrobial peptides and cytokines in the distal ileum was determined by RT-qPCR.ResultsAt 10 and 14 dpi, a significant decrease in total Enterobacteriaceae was observed in the feces of the SFB group. At necropsy, the level of SFB was significantly higher in the SFB group than in the CON group, while a significant decrease in total Enterobacteriaceae and Salmonella was observed in the ceca of the SFB group. RT-qPCR revealed increased expression of β-defensin 14, and cytokines IL-10 and IFNγ.DiscussionThe introduction of SFB at hatch as a prophylactic treatment may benefit commercial partners as well as consumers by reducing the incidence of Enterobacteriaceae in food animals. Reduction of these bacteria in animals would, in turn, increase animal health, productivity, and safety for consumers. Studies to optimize the treatment for poultry industry applications are ongoing in our lab.