bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High‐Rate and Long‐Life Aqueous Rechargeable Mg‐Ion Battery Based on an Organic Anode Integrating Diimide and Triazine
Authors: Cang Ruibai , Zhang Mingyi , Zhou Xuejiao , Zhu Kai , Zhang Xitian , Cao Dianxue 
Published: January 2023

AbstractAqueous Mg‐ion batteries (MIBs) lack reliable anode materials. This study concerns the design and synthesis of a new anode material – a π‐conjugate of 3D‐poly(3,4,9,10‐perylenetracarboxylic diimide‐1,3,5‐triazine‐2,4,6‐triamine) [3D‐P(PDI‐T)] – for aqueous MIBs. The increased aromatic structure inhibits solubility in aqueous electrolytes, enhancing its structural stability. The 3D‐P(PDI‐T) anode exhibits several notable characteristics, including an extremely high rate capacity of 358 mAh g−1 at 0.05 A g−1, A 3D‐P(PDI‐T)‖Mg2MnO4 full cell exhibits a reversible capacity of 148 mAh g−1 and a long cycle life of 5000 cycles at 0.5 A g−1. The charge storage mechanism reveals a synergistic interaction of Mg2+ and H+ cations with C−N/C=O groups. The assembled 3D‐P(PDI‐T)‖Mg2MnO4 full cell exhibits a capacity retention of around 95 % after 5000 cycles at 0.5 A g−1. This 3D‐P(PDI‐T) anode sustained its framework structure during the charge–discharge cycling of Mg‐ion batteries. The reported results provide a strong basis for a cutting‐edge molecular engineering technique to afford improved organic materials that facilitate efficient charge‐storage behavior of aqueous Mg‐ion batteries.
Immunophenotypical profiling of myeloid neoplasms with erythroid predominance using mass cytometry (CyTOF)
Authors: Maag Abdul‐Habib , Swanton Helen , Kull Miriam , Vegi Naidu M. , Feuring Michaela 
Published: January 2023

AbstractAcute erythroid leukemia (AEL) is a disease continuum between Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) with the cellular hallmark of uncontrolled proliferation and impaired differentiation of erythroid progenitor cells. First described by Giovanni di Guglielmo in 1917 AEL accounts for less than 5% of all de novo AML cases. There have been efforts to characterize AEL at a molecular level, describing recurrent alterations in TP53, NPM1 and FLT3 genes. A genomic analysis of AEL cases confirmed its complexity. Despite these advances, the biology underlying erythroid proliferations remains unclear and the prognosis is dismal with a median survival of only 3 months for pure erythroid leukemia (PEL). Marker combinations suitable for the identification and characterization of leukemic stem cell (LSC) candidates, monitoring measurable residual disease (MRD) during chemotherapy treatment and the development of innovative targeted therapies are missing. Here, we developed a mass cytometry panel for an in‐depth characterization of erythroid and myeloid blast cell populations from human AEL bone marrow samples in comparison to other AML subtypes and healthy counterparts. A total of 8 AEL samples were analyzed and compared to 28 AML samples from different molecular subtypes, healthy bone marrow counterparts (n = 5) and umbilical cord blood (n = 6) using high‐dimensional mass cytometry. Identification of erythroid and myeloid blast populations in high‐dimensional mass cytometry data enabled a refined view on erythroblast differentiation stages present in AEL erythroid blasts and revealed immunophenotypical profiles specific to AEL. Profiling of phenotypic LSCs revealed aberrant erythroid marker expression in the CD34+CD38− stem cell compartment. In addition, the identification of novel candidate surface marker combinations and aberrancies might enhance clinical diagnostics of AEL. We present a high‐parameter mass cytometry approach feasible for immunophenotypical analysis of blast and stem cell populations in myeloid neoplasms with erythroid predominance laying the foundation for more precise experimental approaches in the future.
Multi‐institutional questionnaire on treatment strategies for superficial entire circumferential esophageal squamous cell carcinoma
Authors: Kadota Tomohiro , Ishihara Ryu , Hatta Waku , Yoshida Masao , Kanzaki Hiromitsu , Kikuchi Daisuke , Ono Yoichiro , Abe Seiichiro , Yamamoto Yoshinobu , Yoshio Toshiyuki , Urabe Yuji , Yamaguchi Naoyuki , Nagami Yasuaki , Iizuka Toshiro , Takahashi Hiroaki , Oyama Tsuneo , Yano Tomonori 
Published: January 2023

AbstractObjectivesRecent innovations in prophylactic treatment with steroids have overcome the issue of esophageal stricture after endoscopic submucosal dissection (ESD), except in entire circumferential esophageal squamous cell carcinoma (EC‐ESCC). Current Japanese guidelines weakly recommend performing ESD for clinical epithelial/lamina propria EC‐ESCC with a longitudinal extension <50 mm upon implementing prophylactic treatment against stricture. However, the accurate indications for ESD in EC‐ESCC remain unknown, and strategies differ among institutions. The aim of this study was to understand the initial treatment strategy for EC‐ESCC and prophylactic treatment after ESD against esophageal stricture.MethodsA questionnaire survey was conducted across 16 Japanese high‐volume centers on the initial treatment for EC‐ESCC according to the invasion depth and longitudinal extension, and prophylactic treatment against stricture.ResultsESD was performed as the initial treatment not only in clinical epithelial/lamina propria lesions <50 mm (88–94% of institutions), but also in clinical epithelial/lamina propria ≥50 mm (44–50% of institutions) and clinical muscularis mucosae/SM1 (submucosal invasion depth invasion within 200 μm) lesions <50 mm (56–75% of institutions). Regarding prophylactic treatment against esophageal stricture, although there was a common point of local steroid injection, the details and administration of other treatments varied among institutions.ConclusionsAs ESD was performed with expanded indications for EC‐ESCC than those recommended by the guidelines in more than half of the institutions, the validity of ESD for expanded EC‐ESCC needs to be clarified. For that, it is necessary to prospectively collect short‐ and long‐term outcomes after ESD and other treatments, including esophagectomy or chemoradiotherapy.
Association between severe hypoglycaemia and risk of dementia in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis
Authors: Gómez‐Guijarro María Dolores , Álvarez‐Bueno Celia , Saz‐Lara Alicia , Sequí‐Domínguez Irene , Lucerón‐Lucas‐Torres Maribel , Cavero‐Redondo Iván 
Published: January 2023

AbstractThe aim of this systematic review was to analyse whether there is an association between severe hypoglycaemia and the incidence of dementia in patients with type 2 diabetes mellitus. We systematically searched the MEDLINE, Scopus, and Cochrane databases from their inception until September 2022 for observational studies on the association between hypoglycaemia and the risk of dementia. The DerSimonian and Laird method was used to compute a pooled estimate of the risk for such association. Risk ratio (RR) and its respective 95% confidence interval (95% CI). Two analyses were performed to estimate the risk of dementia: (i) any hypoglycaemia versus no hypoglycaemia and (ii) a dose–response analysis for one, two, or more than three hypoglycemic events versus no hypoglycaemia. PROSPERO registration number CRD42020219200. Seven studies were included. The pooled RR for the association of severe hypoglycaemia and risk of dementia was 1.47 (95% CI: 1.24–1.74). When the dose–response trend was analysed, the pooled RR for the risk of dementia was increased according to the hypoglycaemia events as follows: 1.29 (95% CI: 1.15–1.44) for one hypoglycemic event; 1.68 (95% CI: 1.38–2.04) for two hypoglycemic events; and 1.99 (95% CI: 1.48–2.68) for three or more hypoglycemic events. Our study demonstrates a 54% higher risk of dementia among people who suffer a hypoglycaemia event compared to nonhypoglycaemia. Considering our results and the prevalence of people suffering from diabetes mellitus, health education for both newly diagnosed and already diagnosed people could be a useful tool for glycaemic control, thus avoiding hypoglycaemic events.
Autumn fueling behavior in passerines in relation to migratory distance and daylength
Authors: Engert Elana Rae , Hellström Magnus , Åkesson Susanne 
Published: January 2023

AbstractSongbirds have evolved diverse strategies to cope with seasonality, including long‐, medium‐, and short‐distance migration. There is some evidence that birds with a longer migration distance deposit fuel faster. However, most studies focus on long‐distance migrants. Comparisons between species with different migration distances are necessary to broaden our understanding of fueling capacity in migratory birds. We present maximum fuel deposition rates of five songbird species migrating along the southeast coast of Sweden in autumn with migration distances ranging from long (neotropical migrant) to short (partial/irruptive migrant) (Willow Warbler Phylloscopus trochilus, Lesser Whitethroat Curruca curruca, Common Chiffchaff P. collybita, European Robin Erithacus rubecula, and Blue Tit Cyanistes caeruleus). The birds were fed ad libitum in captivity and were exposed to either extended or natural daylength. All species ceased to increase in mass when they reached a certain fuel load, generally corresponding to migration distance, despite unlimited access to food and ample time for foraging. Blue Tits, Willow Warblers, and Lesser Whitethroats had the highest fuel deposition rates with extended daylength (19%, 20%, and 20%, respectively), and about 13% with natural daylength, which is comparable to the highest rates found in migratory songbirds in nature. European Robins and Common Chiffchaffs that winter in the temperate Mediterranean had the lowest fuel deposition rates (12% and 12% with extended daylength, respectively). Our results suggest that the long‐ and short‐distance migrants in this study have developed an extreme capacity for rapid refueling for different reasons; speedy migration to distant wintering grounds or winter survival in Scandinavia. This study contributes to our current knowledge of maximum fuel deposition rates in different species and the limitations posed by daylength. We highlight the need for future studies of species with different migration strategies in order to draw broad conclusions about fueling strategies of migratory birds.
Breeding origins of a uniquely regular migrant songbird in the Galápagos Islands
Authors: Perlut Noah , Maxwell Logan M. , Kovach Adrienne , Parker Patricia , Renfrew Rosalind B. 
Published: January 2023

AbstractLittle is known about the causes and consequences of alternative pathways flown by long‐distance migratory birds. Bobolinks (Dolichonyx oryzivorus) breed in grasslands across northern North America and migrate from their breeding grounds toward the eastern Atlantic Coast and then proceed through the Caribbean to South America. However, a small but regular number of Bobolinks have been recorded on the Galapagos Islands. We collected genetic samples from nine Galapagos Bobolinks and performed double‐digest restriction site‐associated sequencing. We compared them with samples from seven locations across their breeding distribution to determine their population of origin. Galapagos Bobolinks shared the genetic structure of a cluster in the eastern portion of the breeding range that includes New Brunswick and Ontario, Canada, and Vermont, United States. Genetic assignment tests largely corroborated this finding, although slightly different results were obtained for the two methods. All individuals were assigned to the Ontario breeding population using AssignPop, while Rubias assigned six of the migrants to Ontario and three to a Midwest breeding population. Low average relatedness among Galapagos individuals indicates that they are not more related to one another than to individuals within a breeding population and are therefore likely not from a single, small isolated population. Our results do not support the probability hypothesis—that Galapagos Bobolinks originated from the region that includes the greatest proportion of their breeding range (Great Plains)—or the vagrant hypothesis—that migrants are displaced onto Galapagos due to weather events. Instead, our findings support the proximity hypothesis, where migrants originate from the geographically closest‐breeding populations.
Population genetics of the African snakehead fishParachanna obscuraalong West Africa's water networks: Implications for sustainable management and conservation
Authors: Amoutchi Amien Isaac , Kersten Petra , Vogt Asja , Kohlmann Klaus , Kouamelan Essetchi Paul , Mehner Thomas 
Published: January 2023

AbstractAn essential factor for aquatic conservation is genetic diversity or population divergence, which in natural populations reflects the interplay between geographical isolation with restricted gene flow and local evolution of populations. The long geological history of Africa may induce stronger among‐population divergence and lower within‐population divergence in fish populations of African watersheds. As an example, we studied population structure of the African snakehead fishParachanna obscura.Our study aimed: (1) to develop a set of highly polymorphic microsatellite markers suitable for the analysis of genetic diversity amongP. obscuraand (2) to study the genetic diversity and structure ofP. obscurapopulations from the West Africa region and mostly from Côte d'Ivoire, with respect to the effects of climate region and geographical distance on the genetic differentiation. A total of 259 specimens from 15 locations ofP. obscurawere collected over the West Africa region reflecting a high variability of pairwise geographical distances and variability of hydrological connectivity of the area. We developed a set of 21 polymorphic microsatellite markers for studying population genetics of the fish. The results showed relatively low intragenetic diversity for all the 15 locations, certainly attributable to confinement of fish in segregated catchments, resulting in limited gene flow. We also found evidence for local adaptation processes, suggested by five out of 21 microsatellite loci being under putative selection, according to BAYESCAN analysis. In turn, there was strong genetic differentiation (FST > 0.5) among fish from most locations, reflecting the allopatric development in watersheds without hydraulic connectivity. Neighbor‐joining dendrogram, Principal Coordinate Analysis, and analysis of ancestral groups by STRUCTURE suggested that the 15 locations can be divided into three clusters, mainly matching the dominant climate zones and the segregation of the watersheds in the region. The distinct genetic structure of the fish from the 15 locations obtained in this study suggests that conservation and sustainable management actions of this fish resource should avoid genetic mixing of potentially locally adapted populations.
The diversity of resident passerine bird in the East Yunnan‐Kweichow Plateau is closely related to plant species richness, vertical altitude difference and habitat area
Authors: Zhang Haibo , Yan Lingbin , Yu Lifei , Su Haijun , Hu Canshi , Zhang Mingming , Kong Zhihong 
Published: January 2023

AbstractEast Yunnan‐Kweichow Plateau is rich in biodiversity in China. Complex geographical and climatic conditions and rich bird resources made this area an ideal system for studying the spatial distribution mechanism and influencing factors of birds, which were still unknown. Bird community data from 37 sites in this region were collected, including 505 bird species and 164 species of resident passerine bird, were extracted for analysis. The taxonomic diversity, phylogenetic diversity, functional diversity (FD), and community structure index were calculated. Ordinary least square (OLS), spatial autoregressive models (SAR), and structural equation model (SEM) were used to explore the relationship between bird diversity index and environmental factors which were used to describe the habitat conditions of birds. Results indicated that species richness (SR), phylogenetic diversity (PD), and FD have similar distribution patterns and are mainly affected by vascular plant species richness, habitat area, and vertical altitude difference. The phylogenetic and functional structure of bird community changed in both longitude and latitude direction, and the phylogenetic structure of community was dispersed in the west and clustered in the east, significantly related to habitat area, and vertical altitude difference, the functional structure was dispersed in all sites, significantly related to average annual precipitation. The community in the west and south of the East Yunnan‐Kweichow Plateau is mainly driven by interspecific competitive, while the process in the east and north is mainly driven by environmental filtration. Distribution pattern of bird diversity was caused by the comprehensive action of various habitat factors which were mainly related to food availability and habitat heterogeneity. For maintaining the living space of birds, the protection of urban parks, wetland parks, campuses, and other urban green spaces is as important as national and provincial nature reserves. Revealing the construction mechanism and main influencing factors of bird communities in different areas is conducive to targeted protection work.
Epigenetic Regulations in Autoimmunity and Cancer: from Basic Science to Translational Medicine
Authors: Hui Li , Ziyue Zhao , Chao Liu , Bin Yu , Aoyu Li , Haijing Wu 
Published: January 2023

AbstractEpigenetics, as a discipline that aims to explain the differential expression of phenotypes arising from the same gene sequence and the heritability of epigenetic expression, has received much attention in medicine. Epigenetic mechanisms are constantly being discovered, including DNA methylation, histone modifications, noncoding RNAs and m6A. The immune system mainly achieves an immune response through the differentiation and functional expression of immune cells, in which epigenetic modification will have an important impact. Because of immune infiltration in the tumor microenvironment, immunotherapy has become a research hotspot in tumor therapy. Epigenetics plays an important role in autoimmune diseases and cancers through immunology. An increasing number of drugs targeting epigenetic mechanisms, such as DNA methyltransferase inhibitors, histone deacetylase inhibitors, and drug combinations, are being evaluated in clinical trials for the treatment of various cancers (including leukemia and osteosarcoma) and autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis). This review summarizes the progress of epigenetic regulation for cancers and autoimmune diseases to date, shedding light on potential therapeutic strategies.
Distinct spatiotemporal features of microglia and monocyte‐derived macrophages in glioma
Authors: Banerjee Kaveri , Ratzabi Avinoam , Caspit Itai M , Ganon Or , Blinder Pablo , Jung Steffen , Stein Reuven 
Published: January 2023

AbstractGliomas are the most frequent primary tumors of the brain. Glioma progression is regulated by the tumor microenvironment, which is mainly composed of tumor‐associated microglia (TA‐MG) and monocyte‐derived macrophages (MDM). Recent studies have highlighted the distinct properties of these cells in glioma progression. However, their spatiotemporal alteration during tumor progression has not been fully explored. Using a genetic lineage tracing approach, we show that TA‐MG and MDMs differ in their spatiotemporal distribution and interaction with other components of the glioma microenvironment. MDM were present only inside the tumor, whereas TA‐MG accumulated both outside and inside the tumor. However, TA‐MG was eliminated from the tumor mass as the tumor progressed. Depletion of MDM led to enhanced occupancy of TA‐MG in the tumor core, indicating that TA‐MG elimination was regulated by MDM. TA‐MG and MDM are heterogeneous cell populations whose compositions and properties can change during tumor progression. Finally, MG, TA‐MG and MDM were enriched in the perivascular area (PVA) compared to more distal blood vessel‐associated areas. However, inside the tumor, the MDM enrichment in PVA was higher than that in TA‐MG. Collectively, we established that TA‐MG and MDM exhibit different spatiotemporal features in glioma, suggesting distinctive roles during tumor progression.
Periictal water drinking revisited: Occurrence and lateralizing value in surgically confirmed patients with focal epilepsy
Authors: Tanno Yuhei , Matsudaira Takashi , Usui Naotaka , Ogawa Hiroshi , Tokumoto Kentaro , Kawaguchi Norihiko , Kondo Akihiko , Nishida Takuji , Takahashi Yukitoshi 
Published: January 2023

AbstractObjectivePeriictal water drinking (PIWD), which is a rare seizure‐related autonomic behavior, has been reported in temporal lobe epilepsy (TLE) but only rarely in extra‐TLE. Additionally, the lateralizing value of PIWD is controversial. We aimed to clarify the occurrence and lateralizing value of PIWD in patients with focal epilepsy.MethodsThis retrospective study included 240 focal epilepsy patients aged >10 years with a favorable postoperative seizure outcome (Engel class I). PIWD was defined as water drinking behavior during a seizure or within 2 min in the postictal phase. The occurrence of PIWD documented on video‐electroencephalogram monitoring was assessed. The lateralizing value of PIWD was analyzed among patients whose language dominant hemisphere was identified.ResultsTwenty‐three (9.5%) patients exhibited PIWD. PIWD occurred more frequently in frontal lobe epilepsy (FLE; eight of 41 patients, 19.5%) than in TLE (15 of 188 patients, 8%). The occurrence of PIWD was significantly different between FLE and extra‐FLE (P = 0.035), with a low positive predictive value (34.8%). In FLE with PIWD, all but one patient underwent resective surgery involving the medial frontal lobe. In 194 patients whose language dominant hemisphere was determined, the lateralizing value of PIWD in FLE and TLE showed no statistical significance (P = 0.69 and P = 0.27, respectively).SignificancePeriictal water drinking occurred more often in FLE than TLE. Thus, PIWD might not be a specific periictal symptom in TLE. There was no evidence for the lateralizing value of PIWD in FLE and TLE. These findings can provide useful clinical clues for preoperative evaluations to estimate the epileptogenic zone based on seizure semiology and allow for a better understanding of pathophysiological insights into PIWD.
Reactive oxygen species in status epilepticus
Authors: Walker Matthew C 
Published: January 2023

AbstractIt has long been recognized that status epilepticus can cause considerable neuronal damage, and this has become one of its defining features. The mechanisms underlying this damage are less clear. Excessive activation of NMDA receptors results in large rises in internal calcium, which eventually lead to neuronal death. Between NMDA receptor activation and neuronal death are a number of intermediary steps, key among which is the generation of free radicals and reactive oxygen and nitrogen species. Although it has long been thought that mitochondria are the primary source for reactive oxygen species, more recent evidence has pointed to a prominent role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, an enzyme localized in cell membranes. There is burgeoning in vivo and in vitro evidence that therapies that target the production or removal of reactive oxygen species are not only effective neuroprotectants following status epilepticus, but also potently antiepileptogenic. Moreover, combining therapies targeted at inhibiting NADPH oxidase and at increasing endogenous antioxidants seems to offer the greatest benefits.