bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESEARCH OF THE STATE OF WOODY AND BRUSHWOOD PLANTS UNDER ANTHROPOGENIC STRESS CONDITIONS
Authors: Kuzmin Petr A. , Skoblikova Tatyana V. , Gorovoy Sergey A. , Otto Olga V. 
Published: July 2023

Objective. The study of anthropogenic impact on environmental components, primarily on woody and shrub plants, which are the main medium-forming element in natural and artificial ecosystems, is relevant. The subject of this study was the ecological and biological state of plants under conditions of technogenic stress.
Materials and methods. The article presents the results of a study of the life state of woody plants. For this, test plots were laid on the territory of sanitary protection zones of industrial enterprises and in the plantings of main plantings. The quantitative content of tannins and polyphenol oxidase in plant leaves during the active growing season was determined by spectrophotometry and titrimetric analysis.
Results. Vitality decreases in the following order: Betula pendula Roth.> Sorbus aucuparia L.> Rosa majalis Herrn.> Acer negundo L.> Tilia cordata Mill. In plantations of technogenic territories, an increase in damage to the leaf blade is noted, a greater number of dry branches appear in the crown of a tree, compared to the control zone. Thus, in the study area, the lowest life state scores were recorded in Tilia cordata Mill., And the highest vital state scores were recorded in silver birch. In mountain ash, wild rose and American maple, the vital state is average. The increase in the activity of polyphenol oxidase was observed in plantations of technogenic territories, which is a consequence of intensive anthropogenic load on woody plants. Increased activity of polyphenol oxidase helps to decrease the content of tannins in plant leaves. Betula pendula Roth. Sorbus aucuparia L. in the SPZ of industrial enterprises in July, the accumulation of tannins is more intense than in the control plantations.
Conclusion. Betula pendula Roth., Sorbus aucuparia L. in the SPZ of industrial enterprises in July, the accumulation of tannins is more intense than in the control plantations. Spectrophotometric determination of activity helps to understand the reasons why the content of tannins increases or decreases. This fact indicates the participation of tannins in the complex of adaptive reactions of plants, which are associated with protection from aerogenic pollutants. As a result of the study, the most resistant to anthropogenic stress plant species were identified: silver birch, cinnamon rose, and rowan tree.
COMPARATIVE CHARACTERISTICS OF THE RHYTHM OF THE SEASONAL DEVELOPMENT OF SCUTELLARIA BAICALENSIS GEORGI IN THE NON-CHERNOZEM ZONE AND ON THE SOUTH COAST OF THE CRIMEA
Authors: Babaeva Elena Yu. , Minyazeva Yulia M. , Logvinenko Lidiya A. , Molchanova Anna V. 
Published: July 2023

Scutellaria baicalensis is a valuable medicinal plant and a protected species of the East Asian flora. Therefore, work on its introduction is underway in many regions of Russian Federation. Studying of the influence of meteorological factors on the phenology of the S. baicalensis in regions of Russian Federation with contrasting climatic conditions is important in grounds of climate change.
Materials and methods. The object of the study is the population of the S. baicalensis biocollections of All-Russian Scientific Research Institute of Medicinal and Aromatic Plants and Nikitsky Botanical Garden. Meteorological indicators: sum of active temperatures, sum of precipitation. Statistical analysis: Tau-b-Kendall correlation coefficient.
Results. The duration of the growing season in each region has little variability, independently of the weather conditions of the year. The interval between the onset of phenological phases in the Crimea was characterized by weaker variability than in the Non-Chernozem zone. A significantly smaller amount of active temperatures was required for the onset of phenological phases In the Non-Chernozem zone compared to the southern coast of Crimea. The difference in the average sum of active temperatures across the regions reached 1694.6°C by the end of the growing season. The amount of precipitation had sharp fluctuations in both regions and in all years of research.
Conclusion. Secondary flowering, wide amplitudes of the duration of phenological phases and the growing season as a whole, the sum of active temperatures and precipitation indicate the ecological plasticity of the S. baicalensis and the availability of conditions for its cultivation in both regions.
INCREASING THE EFFICIENCY OF THE IMPLEMENTATION OF NATIONAL PROJECTS IN THE FIELD OF HEALTHCARE
Authors: Vaslavskaya Irina Yu. , Poltarykhin Andrey L. , Kolupaev Andrej A. , Vorobyeva Viktoria G. 
Published: July 2023

Objective. This article is devoted to the analysis of the mechanism for the implementation of the national project «Health», as well as the assessment of the effectiveness of its implementation.
Materials and methods. Currently, there is no system for timely and publicly available assessment of the effectiveness of the implementation of the national project «Healthcare» both at the national and regional levels. In this regard, it is proposed to evaluate the effectiveness of the national project according to the methodology based on the integral indicator of effectiveness, developed by the experts of the Higher School of Health Management for assessing the health of the region.
Results. The concept and role of national projects in the regional economy as part of strategic planning is given. The management system and the mechanism for the implementation of the national project in health care at the regional level are disclosed. Techniques for evaluating the effectiveness of the implementation of national projects have been studied. The current state of the implementation of the national project «Healthcare» in the Altai Territory is characterized. The mechanism for the implementation of the national project «Healthcare» is analyzed.
Conclusion. An assessment of the effectiveness of the implementation of the national project showed an insufficient level of implementation of the program in the Altai Territory during 2019-2020, which was facilitated by the COVID-19 pandemic, which significantly worsened the mortality rate among the adult population.
THE ROLE OF ENDODONTICS IN THE TREATMENT OF CHRONIC ODONTOGENIC DISEASES IN PREPARATION FOR PROSTHETICS
Authors: Marugina Tatyana L. , Kiprin Dmitry V. , Cherevatenko Anna I. 
Published: July 2023

Background. When planning orthopedic restoration of significantly destroyed teeth with signs of apical periodontitis, it is necessary to assess the complexity of root canal anatomy as one of the factors influencing successful endodontic dental treatment. Modern approaches in endodontics allow in most cases to achieve the restoration of bone tissue, as well as the elimination of the focus of chronic infection, which allows for subsequent orthopedic dental treatment in order to restore their function and increase the percentage of survival in the oral cavity.
Purpose. Improving the efficiency of orthopedic restoration of teeth with chronic odontogenic infection.
Materials and methods. 64 patients aged 18 to 45 were examined. All had clinical signs of failed endodontic treatment of the incisors in the upper and lower jaws with a dark, radiolucent focus in the apex region, as well as significant destruction of the crown requiring orthopedic restoration. The assessment of radiographic parameters was based on CBCT, and mobility was assessed clinically. The results were evaluated after 6, 12, and 24 months.
Results. All patients showed different signs of restoration of the bone tissue after 6 and 12 months and complete restoration of the bone tissue 24 months after the treatment. No pathological tooth mobility was found 24 months after the end of treatment in 100% (primary endodontic treatment) and 97.5% (repeated endodontic treatment) of patients.
Conclusion. The analysis of the anatomy of the root canals, and, accordingly, the complexity in biomechanical cleaning and washing of the root canals affects the decision to carry out treatment in one or two visits.
AFFECTIVE DISORDERS IN MEN WITH ARTERIAL HYPERTENSION IN COMBINATION WITH METABOLIC SYNDROME
Authors: Yaskevich Roman A. , Moskalenko Olga L. 
Published: July 2023

Purpose. To study the features of affective disorders in men with comorbid chronic coronary heart disease with metabolic syndrome.
Materials and methods. The study was performed with the participation of 115 male patients diagnosed with chronic coronary heart disease. Metabolic syndrome verification was carried out using the clinical recommendations of the All-Russian Scientific Society of Cardiology (2009). Identification of the presence of anxiety-depressive states and assessment of their severity was carried out using The Hospital Anxiety and Depression scale.
Results. The study showed that among men with chronic coronary heart disease who have metabolic syndrome, the median averaged anxiety score on the Hospital Anxiety and Depression scale was significantly higher (p=0,041) compared to those without metabolic syndrome. In 17,6% of the examined patients with a combination of chronic coronary heart disease and metabolic syndrome, elevated levels of anxiety were detected. Anxiety disorders of a subclinically pronounced nature were found in 13,7% of the surveyed in this group, and clinically pronounced in 3,9%. Elevated levels of depression were detected in 17,6% of the examined patients with metabolic syndrome. At the same time, depressive disorders of both subclinically expressed and clinically expressed nature were detected with the same frequency: 7,8% vs 7,8%.
Conclusion. Among patients with chronic coronary heart disease with a comorbid course with metabolic syndrome, the number of people with clinically pronounced anxiety and depression was higher compared to those without metabolic syndrome. In men with chronic coronary heart disease in combination with metabolic syndrome with both increased levels of anxiety and increased levels of depression, 3- and 4-component clusters of metabolic syndrome, including arterial hypertension, abdominal obesity and various dyslipidemias, were more often detected.
THE INFLUENCE OF THE TREATMENT OF IMPULSE PRESSURE ON LIPID PEROXIDATION AND THE CONTENT OF ANTIOXIDANTS IN WHEAT GRAINS DURING AGING
Authors: Khramova Yaroslavna I. , Nefed’eva Elena E. , Khramova Valentina N. 
Published: July 2023

Background. The aging of seeds results in physiological and biochemical changes such as decrease of the activity of antioxidants (AO), and structural and functional degradation of proteins due to lipid peroxidation (LP), as well as degradation of membranes and DNA.
Purpose. Identification of the traits of the antioxidant system of wheat grains with powdery and vitreous endosperm during aging and under the influence of a stressor.
Materials and methods. Soft wheat grains were treated with impulse pressure (IP) and stored for 3 years. Germination was determined. The content AO was determined by the o-phenanthroline method, and LP products were assessed by the reaction of malonic dialdehyde with thiobarbituric acid.
Results. Germination of control seeds with powdery endosperm after storage for 3 years was the lowest (20%). In control part of seeds with vitreous endosperm, germination was 27%. ID increased the amount of seeds with vitreous endosperm and germination. The content of AO in control grains with powdery endosperm was higher than in vitreous grains, and the content of LP products was lower. After the treatment of IP the content of AO increased in vitreous grains; it did not change as compared to the control in powdery grains. The content of LP products in the grains treated with ID 11 MPa was lower than in the control variant. An increase in POL at ID 29 MPa indicates the accumulation of damage;
Conclusion. During the storage of wheat grains, germination decreased mainly due to the appearance of dead grains. The greatest decrease in germination was observed in grains with powdery endosperm. IP promoted vitrification of biopolymers which led to an increase in germination as compared to the control after 3 years of storage. A higher content of AO in grains with vitreous endosperm after IP treatment and storage contributed to the preservation of grain viability during storage.
De pollicitationibus. On the nature of unilateral public promises in Roman law
Authors: Sitek Bronisław 
Published: July 2023

ObjectivesThe subject of the study is the Roman institution of pollicitatio, which is currently unknown. At most, it can be compared to a modern public promise. The institution of pollicitatio appeared in the municipal law and it was a public promise to build a public facility or organize a public event. Such a promise was most often made in connection with running for public office in order to gain the favor of voters. Roman lawyers were already wondering about the nature of this institution and the legal consequences it gave rise to. The institution of pollicitatio was a great support for city budgets, which at that time had full independence from central finance.Material and methodsThe work collects and thoroughly analyzes the most important sources concerning the institution of pollicitatio. The aim of the conducted research is to analyze the political and economic context of the functioning of this sui generi public law institution.ResultsAs a research hypothesis, a thesis was put forward, according to which the municipalities of ancient Rome found a way to implement a solution in order to find finances for the implementation of public utility goals.ConclusionsThe final conclusions stated that the nature of this institution should be clarified by referring it to institutions similar at that time, namely to promissio, donatio, votum or legatum. From the analysis of the sources of Roman law and the comparison of pollicitatio to other similar institutions existing at that time, it can be concluded that it was a unilateral promise to build a public facility or organize a public event by a private person, most often in connection with running for public office.
ОЦЕНКА ПОСЛЕОПЕРАЦИОННОГО ПЕРИОДА У БОЛЬНЫХ ПЕРВИЧНЫМ
ГИПЕРПАРАТИРЕОЗОМ
Authors: Яновская М. Е. , Александров Ю. К. 
Published: July 2023

ЦЕЛЬ: проанализировать течение реабилитационного периода у пациентов после операций по поводу
первичного гиперпаратиреоза (ПГПТ) и выявить особенности его течения.
МАТЕРИАЛЫ И МЕТОДЫ: изучены показатели качества жизни у 234 пациентов (217 женщин, 17 мужчин), которые были оперированы по поводу первичного гиперпаратиреоза (средний возраст пациентов -
57,4 ± 11,6 лет). Патоморфологическое исследование выявило у 187 пациентов аденому околощитовидной
железы (ОЩЖ) (светлоклеточная, из главных клеток, атипическая), а у 47 – гиперплазию ОЩЖ. В исследовании были проанализированы данные клинических, лабораторных и инструментальных исследований
в различные сроки после селективаных паратиреоидэктомий. Для оценки качества жизни пациентов
использовали универсальный опросник SF-36. Пациенты при выполнении контрольных исследований
(определение уровня ПТГ в крови и УЗИ) через 3, 6 и 12 месяцев после вмешательства отвечали на вопросы, содержащиеся в вопроснике. Анализ полученных данных проводился с использованием программы
Statisticа 10 для Windows. (непараметрический парный ранговый критерий Вилкоксона (пороговое значение p < 0,05).
РЕЗУЛЬТАТЫ: после выполнения селективной паратиреоидэктомии все пациенты отмечали достоверное улучшение ФФ, ОЗ, ЖС и ПЗ и статистически незначимые улучшения СФ (p = 0,12) и ТБ (p = 0,07).
Наиболее значительный прирост отмечен у показателя ЖС (p= 0,02). Через 6 месяцев практически все параметры качества показали позитивную динамику. Через 12 месяцев после операции среднее значение SF-36
выросло с 65 ± 15 (до операции) до 96 ± 11 (через 12 месяцев после операции)(p < 0,05). Анализ показал,
что динамика периода реабилитации в первую очередь зависела от давности заболевания и уровня гиперкальцемии до операции. Прямой корреляции динамики уровня ПТГ в крови с оцениваемыми параметрами
качества жизни не установлено. Уровень ПТГ быстро снижался в первые дни после операции, а показатели
здоровья менялись более медленно. Реабилитационный период по оценке показателей качества жизни
у 37 больных (15,8%) имел волнообразный характер. На показателях здоровья этих пациентов негативно
сказывался как высокий, так и низкий уровень Са. В данной группе пациентов преобладала висцеральная
форма ПГПТ. У больных с костной формой ПГПТ был отмечен выраженный положительный тренд восстановления качества жизни на протяжении всего периода наблюдения.
ВЫВОДЫ: при лечении манифестного первичного гиперпаратиреоза, характеризующегося полиморфизмом патологических проявлений со стороны различных органов и систем, селективная паратиреоидктомия является методом выбора, быстро нормализующим гомеостаз. При оценке результатов лечение
приоритетной является оценка качества жизни пациентов.
АНАЛИЗ ЧАСТОТЫ ПОЛИМОРФИЗМОВ ГЕНА РЕЦЕПТОРА ТТГ ПРИ ЭНДОКРИННОЙ
ОФТАЛЬМОПАТИИ
Authors: Батырбекова Ф. Х. , Пантелеева О. Г. , Саакян С. В. , Цыганков А. Ю. 
Published: July 2023

В настоящее время в патогенезе эндокринной офтальмопатии (ЭОП) большое внимание уделяют роли
клеток-мишеней (орбитальные фибробласты и адипоциты), мутаций в генах рецептора тиреотропного
гормона (рТТГ) и инсулиноподобного фактора роста-1(рИФР-1), а также соответствующим им антителам
для разработки потенциально эффективных методов лечения.
ЦЕЛЬ: определить встречаемость полиморфизма гена рТТГ у пациентов с ЭОП.
МАТЕРИАЛЫ И МЕТОДЫ: для проведения молекулярно-генетического исследования (МГИ) взяты
образцы крови у 111 больных, обратившихся ФГБУ НМИЦ ГБ им. Гельмгольца МЗ РФ с подтвержденным
диагнозом ЭОП. Из них, 80 женщины в возрасте от 20 до 79 лет (в среднем 46,6 ± 9,8) и 31 мужчин в возрасте от 26 до 71 лет (в среднем 51 ± 3,5). МГИ проводили в НИИ общей патологии и патофизиологии
методом ПДРФ-анализа лейкоцитов периферической крови, исследуя наличие полиморфизмов гена рТТГ
157561G>A/rs12885526, 15678A>G/rs179247. Определяли наличие мутаций в гене по типу «замены единичного нуклеотида» или SNP (Single Nucleotide Polymorphism). Производили расчет встречаемости дикого,
гомозиготного и гетерозиготного типов полиморфизма гена рТТГ.
РЕЗУЛЬТАТЫ: за последние десятилетия доказана важность рТТГ в патогенезе болезни Грейвса и ЭОП.
Активация рТТГ на орбитальных фибробластах, запускает каскад реакций, приводящих к увеличению продукции гликозамингликанов, влияет на дифференцировку фибробластов в адипоциты. Тем самым, рТТГ стал
терапевтической «мишенью» и исследования мутаций его кодирующего гена актуальны на сегодняшний
день.
В нашем исследовании проведено МГИ гена рТТГ, расчет частоты встречаемости его полиморфизмов (157561G>A/rs12885526, 15678A>G/rs179247) у пациентов с ЭОП. Оба исследуемых полиморфизма
в большинстве случаев имели мутации (по типу замены единичного нуклеотида). Так для полиморфизма
157561G>A/rs12885526 гена рТТГ дикий тип (GG) (вариант нормы) встречался в 18 из 111 случаев. Мутации
данного полиморфизма выявлены в 84% случаев (93 пациента), преимущественно по гетерозиготному типу
(GА) у 53 пациентов и реже по гомозиготному типу (АА) у 40 человек. Таким образом, можно предположить,
что мутация данного гена может быть звеном в патогенезе ЭОП.
Во втором исследуемом полиморфизме гена рТТГ 15678A>G/rs179247 в 58,6% случаев выявлены мутации, дикий тип (АА) (вариант нормы) встретился в 46 из 111 случаев. Мутации данного полиморфизма
встречались преимущественно по гетерозиготному типу (АG) - 72% (47 человек из 65) и реже по гомозиготному типу (GG) 28% (18 пациентов из 65). Полученные результаты могут указывать на роль полиморфизма
данного рецептора по гетерозиготному типу в патогенезе заболевания.
ВЫВОДЫ: МГИ крови позволило выявить преобладание гетерозиготного варианта мутаций исследуемых полиморфизмов (157561G>A/rs12885526, 15678A>G/rs179247) гена рТТГ, что свидетельствует о взаимосвязи между наличием мутаций гена рТТГ и развитием ЭОП.
САНАТОРНО-КУРОРТНОЕ ЛЕЧЕНИЕ ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ
Authors: Марченкова Л. А. , Васильева В. А. 
Published: July 2023

Достижение и поддержание индивидуальных целевых значений гликемии у пациентов с сахарным
диабетом (СД) реализуется с помощью комплексного подхода с использованием не только факрмакологической, но и немедикаментозной терапии.
ЦЕЛЬ: оценить эффективность применения природных и преформированных физических факторов
для профилактики и лечения микро и макрососудистых осложнений СД, в повседневной клинической
практике эндокринологов.
МАТЕРИАЛЫ И МЕТОДЫ: в ходе данного исследования были проанализированы отечественные и зарубежные источники литературы, содержащие информацию по применению природных и преформированных физических факторов для профилактики и лечения осложнений СД.
РЕЗУЛЬТАТЫ: анализ современной литературы показал большую вариативность профилактики, лечения и реабилитации пациентов с сахарным диабетом, в том числе с самым распространенным его осложнением- диабетической полинейропатией нижних конечностей. Мета-анализ проспективных когортных
и обсервационных исследований с использованием гидрокарбонатных и магниевых минеральных вод
показал их положительное влияние на гликемические параметры. В частности, у пациентов с СД продемонстрировала свою эффективность замена диетических или калорийных напитков минеральной водой,
богатой бикарбонатом и магнием. Возможности физиотерапевтических методов при лечении СД включают
оказание анальгетического действия, улучшение функции нервно-мышечного волокна, противовоспалительное действие, улучшение микроциркуляции и метаболизма тканей.
ВЫВОДЫ: таким образом, дополнение стандартов лечения СД физиотерапевтическими методами
санаторно-курортного лечения представляется весьма перспективным.