bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wave after wave: unboxing 40 years of auditing ethics research
Authors: Mardawi Zeena , Seguí-Mas Elies , Tormo-Carbó Guillermina 
Published: March 2023

Purpose
To the best of the authors' knowledge, this is the first study that aims to present a comprehensive view of the auditing ethics literature by unboxing 40 years of efforts in the field.

Design/methodology/approach
This study combined bibliometric, social network and content analysis by analyzing 114 articles published in accounting and top business ethics journals on the Web of Science database from 1980 to 2021.

Findings
The results show a rising interest in this topic and reveal auditors’ ethical decision-making and moral reasoning as the most discussed topics in the literature. The work also clusters the literature according to keywords and scopes, identifying literature gaps and suggesting new avenues for future research.

Practical implications
The research results assist provide an overarching image of the auditing ethics field. In addition, these results draw possible future avenues to bridge the void in the current auditing ethics literature by presenting indispensable directions for potential research. For example, future research could pay more attention to whistleblowing, fraud, personal auditor characteristics, auditor ethical sensitivity, auditor ethical conflict, ethical climate and underreporting of time. Moreover, the rapidly changing business environment necessitates the auditing ethics research to move to more practical implications to mitigate previous mistakes and avoid any future risks.

Originality/value
All crises are an ideal breeding ground to motivate fraud and audit failures. In fact, auditing ethics research has been subordinated to the different economic crises. However, despite increasing awareness of the topic’s relevance, no comprehensive study focuses on auditing ethics literature. Now, the devastating effects of the COVID-19 crisis are producing a new wave of financial distresses and avoiding former mistakes is timelier than ever. With this novel and integrated approach, this work goes one step forward, developing a comprehensive picture of the auditing ethics literature.
Orthographic and phonological processing effects on the reading abilities of young children learning to read Malayalam alphasyllabary
Authors: Joy Jeena Mary , Venkatesh Lakshmi , Mathew Samuel N. , Narayanan Swapna 
Published: March 2023

BackgroundLearning to read is a complex process that involves phonological and orthographic processing abilities, broader language skills and cognitive processes across all writing systems. Although these components remain common, the pace of acquisition of phonological and orthographic processing and reading abilities differ across writing systems.MethodsThis study aimed to understand the developmental pattern of reading and phonological processing, assess their interrelationship and study the predictors of reading ability among 175 children, learning to read Malayalam and attending Grades 1–3. They completed various reading (akshara reading, word and nonword reading) and phonological processing (rhyme recognition, syllable deletion, syllable segmentation, phoneme deletion, phoneme substitution, rapid naming and nonword repetition) tasks.ResultsGrade and reading level‐based analysis was performed to collate the results. Results revealed a significant overlap of phonological processing and reading abilities among children in Grades 2 and 3. Reading scores demonstrated a weak‐to‐moderate significant correlation with the phonological processing tasks. Although skilled readers performed significantly better on all phonological processing tasks, their scores did not reach ceiling. Syllable‐level tasks were easier compared to phoneme‐level tasks, and they significantly predicted the reading abilities of children.ConclusionsThe findings contribute to the existing body of evidence for akshara writing systems, specifically in Malayalam alpha‐syllabary. The development of phonological processing and reading in Malayalam extends beyond the third grade, and syllable processing contributed to increased variance in reading accuracy among inexperienced readers.
Effect of cold plasma processing on physicochemical and nutritional quality attributes of kiwifruit juice
Authors: Kumar Sitesh , Pipliya Sunil , Srivastav Prem Prakash 
Published: March 2023

AbstractCold plasma treatment of kiwifruit juice was studied in the domain of 18–30 kV of voltage, 2–6 mm of juice depth, and 6–10 min of treatment time using the response surface methodology (RSM). The experimental design utilized was a central composite rotatable design. The effect of voltage, juice depth, and treatment time on the various responses, namely peroxidase activity, color, total phenolic content, ascorbic acid, total antioxidant activity, and total flavonoid content, was examined. While modeling, the artificial neural network (ANN) showed greater predictive capability than RSM as the coefficient of determination (R2) value of responses was greater in the case of ANN (0.9538–0.9996) than in RSM (0.9041–0.9853). The mean square error value was also less in the case of ANN than in RSM. The ANN was coupled with a genetic algorithm (GA) for optimization. The optimum condition obtained from ANN‐GA was 30 kV, 5 mm, and 6.7 min, respectively.
Real‐world therapeutic effectiveness of lorlatinib after alectinib in Japanese patients with ALK‐positive non‐small‐cell lung cancer
Authors: Goto Yasushi , Shukuya Takehito , Murata Ai , Kikkawa Hironori , Emir Birol , Wiltshire Robin , Miura Satoru 
Published: March 2023

AbstractAlectinib, an anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), is the recommended first‐line treatment for ALK‐positive non‐small‐cell lung cancer (NSCLC) in Japan. Lorlatinib was approved as a subsequent therapeutic option after progression while receiving ALK TKI treatment. However, data on the use of lorlatinib in the second‐ or third‐line setting after alectinib failure are limited in Japanese patients. This retrospective real‐world observational study investigated the clinical effectiveness of lorlatinib in second‐ or later‐line settings after alectinib failure in Japanese patients. Clinical and demographic data collected in the Japan Medical Data Vision (MDV) database between December 2015 and March 2021 were used. Patients diagnosed with lung cancer who received lorlatinib following alectinib failure after the November 2018 marketing approval of lorlatinib in Japan were included. Of 1954 patients treated with alectinib, 221 were identified from the MDV database as receiving lorlatinib after November 2018. The median age of these patients was 62 years. Second‐line lorlatinib treatment was reported for 154 patients (70%); third‐ or later‐line lorlatinib treatment was reported for 67 patients (30%). The median duration of treatment (DOT) for all lorlatinib‐treated patients was 161 days (95% confidence interval [CI], 126–248), and 83 patients (37.6%) continued treatment after data cut‐off (March 31, 2021). Median DOTs of 147 days (95% CI, 113–242) and 244 days (95% CI, 109 to not reached) were reported with second‐line and third‐ or later‐line treatment, respectively. Consistent with clinical trial data, this real‐world observational study supports data suggesting the effectiveness of lorlatinib after alectinib failure in Japanese patients.
Panax notoginseng saponins promote hair follicle growth in mice via Wnt/β‐Catenin signaling pathway
Authors: Huang Dan , Gong Zhen‐yu , Liu Shun‐cai , Zheng Xian‐ping , Kyaw Kaung Myat , Lin Bo‐jie 
Published: March 2023

AbstractPanax notoginseng saponins (PNS), the active ingredients of the traditional Chinese medicine Panax notoginseng, have strong neuroprotective and anti‐platelet aggregation effects. To investigate whether PNS can promote hair follicle growth in C57BL/6J mice, the optimal concentration of PNS was initially determined, followed by clarification of the mechanism underlying their effects. Twenty‐five male C57BL/6J mice had the hair on a 2 × 3 cm2 area of the dorsal skin shaved and were equally divided into five groups: control group, 5% minoxidil (MXD) group, and three PNS treatment groups [2% (10 mg/kg), 4% (20 mg/kg), and 8% (40 mg/kg) PNS]. They were then intragastrically administered the corresponding drugs for 28 days. The effects of PNS on C57BL/6J mice were analyzed by subjecting their dorsal depilated skin samples to different assessments, including hematoxylin and eosin staining, immunohistochemistry, immunofluorescence, quantitative real‐time polymerase chain reaction (qRT‐PCR), and Western blotting (WB). The group with 8% PNS exhibited the largest number of hair follicles from 14 days onwards. Compared with the control group, the number of hair follicles increased significantly in the mice treated with 8% PNS and 5% MXD, which significantly increased in a PNS‐dose‐dependent manner. Immunohistochemistry and immunofluorescence results revealed that treatment with 8% PNS activated the metabolism of hair follicle cells, with them showing higher rates of proliferation and apoptosis than those in the normal group. In qRT‐PCR and WB analysis, the expression of β‐catenin, Wnt10b, and LEF1 was upregulated in the PNS and MDX groups compared with that in the control group. Examination of the WB bands revealed that the greatest inhibitory effect of Wnt5a occurred in mice in the 8% PNS group. PNS may promote the growth of hair follicles in mice, with 8% PNS demonstrating the strongest effect. The mechanism behind this may be related to the Wnt/β‐catenin signaling pathway.
Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study
Authors: Jalleh Ryan J. , Trahair Laurence G. , Wu Tongzhi , Standfield Scott , Feinle‐Bisset Christine , Rayner Christopher K. , Horowitz Michael , Jones Karen L. 
Published: March 2023

AbstractAimTo evaluate the effect of gastric distension, induced using a gastric ‘barostat’, on the secretion of glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) in the presence and absence of small intestinal nutrients in healthy individuals.Materials and MethodsEight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure.ResultsFollowing intraduodenal saline or glucose infusion, there was no difference in plasma GLP‐1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).ConclusionsGastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
Understanding the transmission of crash risk between cryptocurrency and equity markets
Authors: Dai Peng‐Fei , Goodell John W. , Huynh Luu Duc Toan , Liu Zhifeng , Corbet Shaen 
Published: March 2023

AbstractWe evidence that cryptocurrencies have a higher probability of crashes than equity indices, although such crashes are of shorter duration. Commonality of crash risk between cryptocurrency and equity markets occur in approximately 80% of the periods examined. Further, recently evolved cryptocurrency uncertainty indices are more relevant for predicting co‐crash behavior than economic policy uncertainty. Results are consistent with cryptocurrencies being a growing source of financial instability.
Diagnostic utility of FOXO1 immunohistochemistry for rhabdomyosarcoma classification
Authors: Rutland Cooper D , Gedallovich Jodi , Wang Aihui , Zdravkovic Sabrina , Varma Sushama , Hornick Jason L , Charville Gregory W 
Published: March 2023

AimsRhabdomyosarcomas currently are classified into one of four subtypes (alveolar, embryonal, spindle cell/sclerosing, or pleomorphic) according to their morphological, immunohistochemical, and molecular genetic features. The alveolar subtype is characterised by a recurrent translocation involving PAX3 or PAX7 and FOXO1; identification of this translocation is important for appropriate classification and prognostication. In this study, we aimed to explore the diagnostic utility of FOXO1 immunohistochemistry for rhabdomyosarcoma classification.Methods/resultsA monoclonal antibody targeting a FOXO1 epitope retained in the fusion oncoprotein was used to study 105 rhabdomyosarcomas. FOXO1 was positive for expression by immunohistochemistry in all 25 alveolar rhabdomyosarcomas, with 84% showing diffuse expression in greater than 90% of neoplastic cells; the remainder of alveolar rhabdomyosarcomas displayed at least moderate staining in a minimum of 60% of lesional cells. Apart from three spindle cell rhabdomyosarcomas showing heterogeneous nuclear immunoreactivity in 40–80% of tumour cells, the 80 cases of embryonal, pleomorphic, and spindle cell/sclerosing rhabdomyosarcoma were negative for FOXO1 expression (96.3% specific) when using a threshold of nuclear staining in 20% of neoplastic cells to determine positivity. Variable cytoplasmic staining was present in a fraction of all rhabdomyosarcoma subtypes. Nonneoplastic lymphocytes, endothelial cells, and Schwann cells also showed variably intense nuclear anti‐FOXO1 immunoreactivity.ConclusionTaken together, our findings suggest that FOXO1 immunohistochemistry is a highly sensitive and relatively specific surrogate marker of the PAX3/7::FOXO1 fusion oncoprotein in rhabdomyosarcoma. Cytoplasmic immunoreactivity, expression in nonneoplastic tissues, and limited nuclear staining of nonalveolar rhabdomyosarcomas represent potential pitfalls in interpretation.
Cosmetic effects of red‐light reflection by ultramarine blue pigment
Authors: Ikkai Fumiyoshi , Blaksley Carl , Hayashi Rena , Jaspers Alexander 
Published: March 2023

AbstractObjectiveInorganic pigments used as colouring agents in cosmetics (especially foundations) have many advantages over organic pigments, such as better opacity, weather and chemical resistance and lower cost. However, the types used in cosmetics are very limited, with various kinds of red, yellow and black iron oxide along with white titanium dioxide being the main materials. Ultramarine blue (UB) as a blue pigment and chromium oxide as a green pigment are also sometimes used in cosmetics. In this study, we focus once again on UB and reexamine the possibility of expanding the colour gamut using UB instead of black pigment and creating other optical cosmetic effects.MethodsThe effects of using UB were measured using spectroscopic instruments to determine the colour parameters when applied on artificial skin. The appearance of the product when applied to the human face was also verified both in terms of human appearance evaluation by an expert (esthetician) and numerical evaluation using imaging spectrometer measurements.ResultsThe verified results showed that, at least in the colour range targeting Asian people, UB could not create a new colour gamut, but it was clear that UB could impart an optical effect that produced a beautiful skin effect on the face. This was remarkable both in the evaluation of human appearance and in the spectral measurement results, which confirmed the phenomenon “red‐light makes skin look beautiful,” which has been variously reported since the 2000s, using a different approach.ConclusionWe have discovered a new possibility that UB, widely recognized as a pigment, is involved not only in colour tone but also in optical effects that contribute to the goal of beautiful skin, i.e. hiding skin wrinkles, eliminating unevenness of colour and improving skin homogeneity.
Physicochemical and functional properties of pectic polysaccharides extracted with four different chelators from sesame hull
Authors: Guo Qing , Xu Shuai , Zhao Xiao‐Juan , Liu Hua‐Min , Qin Zhao , Wang Xue‐De 
Published: March 2023

SummarySesame hull is a byproduct of sesame processing and is currently treated as waste, but it could be an important source of pectic polysaccharides. To increase the value of the sesame crop, pectic polysaccharides were extracted from sesame hull using four different chelators, namely trans‐cyclohexane‐1,2‐diamine tetraacetic acid (CDTA), ethylene diamine tetraacetic acid (EDTA), sodium tripolyphosphate (STLP), and sodium hexametaphosphate (SHMP), which were named CSP, ESP, STP, and SHP, respectively. Physicochemical and functional properties were assessed. SHP mainly contained homogalacturonan (HG) linear regions but the others had more branching with rhamnogalacturonan (RG‐I) as the predominant region. CSP showed the highest molecular weight (155 kDa) with a smooth surface. The molecular weight of ESP, STP, and SHP ranged from 40 kDa to 90 kDa and presented cracked surfaces. Furthermore, CSP had the highest oil holding capacity (9.03 g oil g−1 dry matter). ESP showed Newtonian‐fluid characteristics (n = 1.06) and weaker thermal stability than others. STP had the highest viscosity and good emulsifying stability in concentrations of 1% and 2%. SHP showed excellent water holding capacity, foaming capacity, emulsifying stability, and antioxidant activity. This study provides valuable information for selecting a suitable chelator to extract desirable pectic polysaccharides from sesame hull waste.
The nature and extent of food marketing on Facebook, Instagram, and YouTube posts in Mexico
Authors: Valero‐Morales Isabel , Nieto Claudia , García Abad , Espinosa‐Montero Juan , Aburto Tania C. , Tatlow‐Golden Mimi , Boyland Emma , Barquera Simón 
Published: March 2023

SummaryFood and beverage marketing appealing to children and adolescents has an impact on their food preferences, purchases requests, consumption patterns, health outcomes, and obesity. The objective of this study was to assess the nature and extent of food and beverage marketing on Facebook, Instagram, and YouTube posts in Mexico. This was a content analysis that followed the World Health Organization CLICK methodology to comprehend the landscape of digital food marketing campaigns of the top‐selling food products and brands and the most popular accounts carried out between September and October 2020. A total of 926 posts from 12 food and beverage products and 8 brands were included. Facebook was the social media platform with the most posts and greatest engagement. The most prevalent marketing techniques were brand logo, image of packaging, image of the product itself, hashtags, and engagement to consume. Fifty percent of the posts were assessed as appealing to children, 66% to adolescents, and 80% to either children or adolescents. Ninety‐one percent of products (n = 1250) were classified as unhealthy according to the Mexican warning labels nutrient profile; 93% of the food promoted on posts appealing to either children or adolescents were unhealthy. Hashtags commonly referred to the COVID‐19 pandemic. Most of the unhealthy food digital marketing features marketing techniques that appeal to children or adolescents; moreover, the use of the pandemic hashtag reflected brands' responsiveness to the environment at the time of the study. The present data contribute to evidence supporting the strengthening of food marketing regulations in Mexico.
Characterization of hemocytes from the marine amphipod Parhyale hawaiensis (Dana 1853): Setting the basis for immunotoxicological studies
Authors: dos Santos Amanda , Botelho Marina Tenório , Joviano Willian Reina , Gomes Vicente , da Silva José Roberto Machado Cunha , de Aragão Umbuzeiro Gisela 
Published: March 2023

AbstractHemocytes are circulating blood cells that play a crucial function in amphipods and other crustacean immune systems. The hemocytes of the marine tropical amphipod Parhyale hawaiensis have been used for the evaluation of DNA damage and micronuclei, but they have not been characterized in the scientific literature. The aim of this study was to describe the hemolymph cells of P. hawaiensis and study their phagocytotic activity. Basic dyes were used to differentiate the cell types and the presence of lipids. The total hemocyte counts (THCs) and the proportion and sizes of the hemocyte types were determined. Hemolymph was exposed to Escherichia coli for verification of the presence of phagocytosis. Three cell types, all containing lipids, were identified in P. hawaiensis: granulocytes (oval shape, 13.4 × 7.6 μm), semi‐granulocytes (oval shape, 14.1 × 7.2 μm), and hyalinocytes (round shape, 9.6 × 7.2 μm). Those three cell types were found in different percentages in males (64.8%, 31.1%, and 4.2%) and females (70.1%, 28.2%, and 1.7%). THCs for males were 9007 ± 3800 cells per individual and 4695 ± 1892 cells per individual for females. The cells of E. coli were phagocytized by the hemocytes. Our findings increased the knowledge of hemocytes in P. hawaiensis and is a step forward in using hemocyte‐based immune responses as an endpoint in ecotoxicology.
Rheological assessment of metakaolin‐based geopolymer composites through squeeze flow
Authors: Brandvold Allison S. , Trindade Ana Carolina Constâncio , Kriven Waltraud M. 
Published: March 2023

AbstractGeopolymer (GP) composites show great potential as a replacement for ordinary Portland cement (OPC) in construction material, extrusion‐based, and additive manufacturing. The rheological properties of highly viscous and reinforced systems have not yet been well studied, due to limitations in the current state of the art rheometers and viscometers, such as size and torque limits. In this study, the basic rheological properties of highly reinforced, geopolymer composites with potential for 3D printing are innovatively investigated with “squeeze flow” and “flow table” tests commonly used in civil engineering. Squeeze‐flow rates of 0.1, 1.0, and 3.0 mm/s were assessed with varying sand weight percentages or basalt fiber lengths and compared to a conventional OPC mixture to differentiate the flow properties and deformation resistance of both materials. It is shown that the deformation resistance as a result of jamming increases with increasing solid reinforcement percentages, but that the overall effect of fiber size is somewhat inconclusive. In addition, the effect of squeeze‐flow rate exhibits an increase in load required to initiate flow at lower squeezing rates, but, upon reaching a certain ratio of solids to liquid in the matrix, the results become variable.
‘I just need a plan’: Consumer perceptions of waiting for healthcare
Authors: Harding Katherine E. , Lewis Annie K. , Taylor Nicholas F. 
Published: March 2023

AbstractRationaleWait lists are common in the provision of publicly funded services in outpatient and community settings.Aims and ObjectivesWe aimed to explore the experiences of consumers on wait lists across a broad range of services and to understand the impact of delays in access to services on people's lives.MethodsConsumers with experience of being on a wait list for an outpatient or community‐based health service participated in one of three focus groups. Data were transcribed and analysed inductively using a thematic approach.ResultsWaiting for healthcare has detrimental impacts on health and well‐being. Consumers on wait lists want their health needs addressed, but they also want the ability to plan, clear communication and to feel like someone cares. Instead, they feel forgotten by impersonal and inflexible systems with very little communication, with emergency departments and general practitioners often left to fill in the gaps.ConclusionsMore consumer‐centred approaches are needed for access systems for outpatient and community services, featuring honesty about what services can realistically be provided, early access to initial assessment and information and clear lines of communication.