bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Leading to Heavy Rainfall in Southern Taiwan in the Early Mei-Yu Season of 2020
Authors: Chien Fang-Ching , Chiu Yen-Chao 
Published: April 2023

Abstract
This paper examines the meteorological factors that led to the record-breaking heavy precipitation event in Taiwan in the early 2020 mei-yu season (15–31 May). The extreme amount of rainfall (an average of 135.9 mm per station) during the 36-h period around 22 May (hereafter Y20R) also set a record. Compared to climatology, the Pacific subtropical high was stronger and the southwesterly monsoonal flow was more intense during the first half of the 2020 mei-yu season, resulting in a stronger moisture conveyor belt over the northern Indo-China Peninsula. The record-breaking precipitation in Y20R was mainly caused by the eastward movement of a southwest vortex (SWV) generated in southwestern China. When the eastern portion of the SWV touched northern Taiwan, its associated west-southwesterly winds and the large-scale southwesterly monsoonal flow transported moisture toward the Taiwan Strait. The moisture-laden southwesterly flow was lifted by the stationary mei-yu front, leading to the heavy rainfall in southern Taiwan. When the SWV passed through northern Taiwan, it became the dominant weather system that enhanced the west-southwesterly winds and transported moisture from South China to Taiwan. The front moved southward through the Taiwan Strait during this period, with its location greatly determining the pattern of rainfall in southern Taiwan. In summary, the most critical factors leading to heavy rainfall in southern Taiwan are the strong 850-hPa southwesterly winds and moisture fluxes associated with the SWV. The other key factors include, in order of sensitivity to rainfall, the distance of the front, the distance of the SWV, the frontal speed, and the intensity of the SWV.
Adaptation of θ-Based Dynamical Cores for Extension into the Thermosphere Using a Hybrid Virtual Potential Temperature
Authors: Eckermann Stephen D. , Barton Cory A. , Kelly James F. 
Published: April 2023

Abstract
The virtual temperature used to model moisture-modified tropospheric dynamics is generalized to include a new thermospheric component. The resulting hybrid virtual potential temperature (HVPT) transitions seamlessly with height, from moist virtual potential temperature (MVPT) in the troposphere, to potential temperature in the stratosphere and mesosphere, to thermospheric virtual potential temperature thereafter. For numerical weather prediction (NWP) models looking to extend into the thermosphere, but still heavily invested in retaining MVPT-based dynamical cores for tropospheric prediction, upgrading to HVPT allows the core to capture critical new aspects of variable composition thermospheric dynamics, while leaving the original MVPT-based tropospheric equations and numerics essentially untouched. In this way, HVPT augmentation can both simplify and streamline extension into the thermosphere at little computational cost beyond the inevitable need for more vertical layers and somewhat smaller time steps. To demonstrate, we upgrade the MVPT-based dynamical core of the Navy global NWP model to HVPT, then test its performance in forecasting analytical globally balanced states containing hot or rapidly heated thermospheres and height-varying gas constants. These tests confirm that HVPT augmentation offers an efficient and effective means of extending MVPT-based NWP models into the thermosphere to accelerate development of future ground-to-space NWP models supporting space weather applications. The related issues of variable gravitational acceleration and shallow-atmosphere approximations are also briefly discussed.
Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study
Authors: Shafaee Hooman , Ghiasi Mohammadparsa , Rahimi Hamidreza , Rangrazi Abdolrasoul 
Published: April 2023

Aim: To compare the effect of nano micelles curcumin and ibuprofen on pain reduction after primary arch wire placement in orthodontic patients. Materials and Methods: In this double-blind randomized clinical trial study, 60 female patients between the ages of 14 and 30 years who had moderate tooth crowding and were candidates for fixed orthodontic treatment were examined. The subjects were divided into four groups ( n = 15) of nano micelles curcumin (SinaCurcumin), ibuprofen, placebo of SinaCurcumin, and placebo of ibuprofen. Each patient received a questionnaire and a rectangular, flexible cube of silicone to record the severity of their pain under each of the three situations (biting posterior teeth together, fitting anterior teeth together, and without fitting the teeth together) at the designated time points (2 h, 6 h, bedtime, the second, third, and seventh days after archwire placement). The obtained outcomes were statistically verified and analyzed by the employment of SPSS Statistics Version 22. Results: despite the lack of any significant differences among the four groups in terms of pain severity upon biting by the anterior teeth 2 h after the intervention, there was a considerable difference in the cases of 6 h, bedtime, and the second, third, and seventh days subsequent of the placement of archwire. Our data indicated a lower rate of pain severity for SinaCurcumin group than the placebo of SinaCurcumin and ibuprofen groups at 6 h after the archwire placement. However, the pain severity of SinaCurcumin group at bedtime was significantly lower than ibuprofen group, which also resulted in a notably lower rate than the other groups at the second, third, and seventh days after the placement of archwire. Conclusion: These findings support the effectiveness of curcumin in reducing the pain severity of orthodontic patients. Nevertheless, it is a necessity to conduct further confirmation trials on this latter.
Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT
Authors: Geerlinks Ashley V. , Scull Brooks , Krupski Christa , Fleischmann Ryan , Pulsipher Michael A. , Eapen Mary , Connelly James A. , Bollard Catherine M. , Pai Sung-Yun , Duncan Christine N. , Kean Leslie S. , Baker K. Scott , Burroughs Lauri M. , Andolina Jeffrey R. , Shenoy Shalini , Roehrs Philip , Hanna Rabi , Talano Julie-An , Schultz Kirk R. , Stenger Elizabeth O. , Lin Howard , Zoref-Lorenz Adi , McClain Kenneth L. , Jordan Michael B. , Man Tsz-Kwong , Allen Carl E. , Marsh Rebecca A. 
Published: April 2023

Abstract
Overall survival after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) using alemtuzumab, fludarabine, and melphalan is associated with high rates of mixed chimerism (MC) and secondary graft failure (GF). We hypothesized that peritransplantation alemtuzumab levels or specific patterns of inflammation would predict these risks. We assessed samples from the Bone Marrow Transplant Clinical Trials Network 1204 (NCT01998633) to study the impact of alemtuzumab levels and cytokine patterns on MC and impending or established secondary GF (defined as donor chimerism &lt;5% after initial engraftment and/or requirement of cellular intervention). Thirty-three patients with hemophagocytic lymphohistiocytosis (n = 25) and other IEIs (n = 8) who underwent HCTs with T-cell–replete grafts were included. Patients with day 0 alemtuzumab levels ≤0.32 μg/mL had a markedly lower incidence of MC, 14.3%, vs 90.9% in patients with levels &gt;0.32 μg/mL (P = .008). Impending or established secondary GF was only observed in patients with day 0 alemtuzumab levels &gt;0.32 μg/mL (P = .08). Unexpectedly, patients with impending or established secondary GF had lower CXCL9 levels. The cumulative incidence of impending or established secondary GF in patients with a day 14+ CXCL9 level ≤2394 pg/mL (day 14+ median) was 73.6% vs 0% in patients with a level &gt;2394 pg/mL (P = .002). CXCL9 levels inversely correlated with alemtuzumab levels. These data suggest a model in which higher levels of alemtuzumab at day 0 deplete donor T cells, inhibit the graft-versus-marrow reaction (thereby suppressing CXCL9 levels), and adversely affect sustained engraftment in the nonmyeloablative HCT setting. This trial was registered at www.clinicaltrials.gov as #NCT01998633
Primary healthcare competencies needed in the management of person-centred integrated care for chronic illness and multimorbidity: Results of a scoping review
Authors: Michielsen Leslie , Bischoff Erik W.M.A. , Schermer Tjard , Laurant Miranda 
Published: April 2023

Abstract
Background
Chronic disease management is important in primary care. Disease management programmes focus primarily on the respective diseases. The occurrence of multimorbidity and social problems is addressed to a limited extent. Person-centred integrated care (PC-IC) is an alternative approach, putting the patient at the centre of care. This asks for additional competencies for healthcare professionals involved in the execution of PC-IC. In this scoping review we researched which competencies are necessary for healthcare professionals working in collaborative teams where the focus lies within the concept of PC-IC. We also explored how these competencies can be acquired.

Methods
Six literature databases and grey literature were searched for guidelines and peer-reviewed articles on chronic illness and multimorbidity in primary care. A data synthesis was carried out resulting in an overview of the competencies that healthcare professionals need to deliver PC-IC.

Results
Four guidelines and 21 studies were included and four core competencies could be derived through the synthesis: 1. interprofessional communication, 2, interprofessional collaborative teamwork, 3. leadership and 4. patient-centred communication. Included papers mostly lack a clear description of the competencies in terms of knowledge, skills and attitudes which are necessary for a PC-IC approach and on how these competencies can be acquired.

Conclusion
This review provides insight on competencies necessary to provide PC-IC within primary care. Research is needed in more depth on core concepts of these competencies which will then benefit educational programmes to ensure that healthcare professionals in primary care are better equipped to deliver PC-IC for patients with chronic illness and multimorbidity.
Unmet needs with antipsychotic treatment in schizophrenia and bipolar I disorder: patient perspectives from qualitative focus groups
Authors: Doane Michael J. , Raymond Kimberly , Saucier Cory , Bessonova Leona , O’Sullivan Amy K. , White Michelle K. , Foster April Mitchell , LaGasse Kaitlin , Carpenter-Conlin Julia , Sajatovic Martha , Velligan Dawn I. 
Published: April 2023

Abstract
Background
Schizophrenia (SZ) and bipolar I disorder (BD-I) are chronic mental health disorders often treated with antipsychotic medications. This qualitative study sought to better understand disease burden and treatment experiences with oral antipsychotic medications in participants living with SZ or BD-I.

Methods
Six 90-min focus groups were conducted with participants diagnosed with SZ or BD-I. Trained moderators facilitated discussions using a semistructured guide. Participants described symptoms, impacts of disease, and experiences with oral antipsychotic medications, whether favourable or unfavourable.

Results
Among participants with SZ (n = 15; 3 groups, 5 per group), 53% were male and 33% were white, with a mean of 18.6 years since diagnosis. Of participants with BD-I (n = 24; 3 groups, 8 per group), 33% were male and 42% were white, with a mean of 13.0 years since diagnosis. Participants described numerous symptoms of their illnesses that impacted relationships and daily life, including effects on emotional health, the ability to work, and encounters with law enforcement. Previous antipsychotic medications were deemed effective by 14/15 (93%) participants with SZ and 12/16 (75%) participants with BD-I. Most participants with SZ (13/15; 87%) or with BD-I (16/24; 67%) reported discontinuing their antipsychotic medication at some point. Side effects were a common reason for discontinuing or switching medications for participants with SZ (8/15; 53%) and for those with BD-I (11/24; 46%). The most common side effects reported in both cohorts were weight gain, drowsiness, sexual problems, and neurologic symptoms. Side effects negatively affected quality of life, leading to serious health problems and issues with self-esteem.

Conclusions
People living with SZ or BD-I cited a range of favourable and unfavourable experiences with oral antipsychotic medications. Most participants reported that their antipsychotics were effective at controlling their symptoms, but multiple side effects impacted their quality of life, caused additional serious health problems, and often led to discontinuation of or switching antipsychotics. Findings from this study contribute to a better understanding of patients’ experiences with antipsychotics and highlight a need for new medications with favourable benefit/risk profiles.
Investigating the effect of multimedia education based on the health belief model in preventing COVID-19 in pregnant women
Authors: Shakerinejad Ghodratollah , Navak Tayebeh , Hatemzadeh Nasser , Haghi Mehdi , Haghigizadeh Mohammad Hossein 
Published: April 2023

Abstract
Background
Pregnant women are considered one of the high-risk groups during the COVID-19 pandemic, so paying attention to preventive behaviors among them is highly important. This study aimed to examine the effect of multimedia education based on the Health Belief Model (HBM) in preventing COVID-19 among pregnant women.

Methods
This quasi-experimental intervention study was conducted on 120 pregnant women referring to Comprehensive Health Services Centers affiliated with East and West health centres of Ahvaz city, Iran, in 2021. Participants were divided into two control (n = 60) and intervention (n = 60) groups. A researcher-made questionnaire was used for data collection. The intervention group was given the required educational content using social networks virtually and multimedia in 12 sessions. Both groups were reinvestigated after two months. Data were analyzed using SPSS software version 24, independent t-test and paired t-test tests.

Results
The mean age and mean gestational age of participants were estimated at 28 years old and 18 weeks, respectively. Before the educational intervention, there was no significant difference in mean constructs of HBM. In contrast, the mean of all constructs increased significantly in the intervention group after intervention. The greatest change was related to the constructs of self-efficacy and perceived susceptibility, and the lowest change was related to the perceived barriers construct.

Conclusion
Our findings suggest multimedia education using the HBM to COVID-19 preventive behaviors among pregnant women can benefit behavior change.
Bangpungtongsung-san for patients with major depressive disorder: study protocol for a randomized controlled phase II clinical trial
Authors: Kim Yunna , Choi Yujin , Lee Mi Young , Cho Seung-Hun , Jung In Chul , Kang Dong-Hoon , Yang Changsop 
Published: April 2023

Abstract
Background
Bangpungtongsung-san (BTS) is a representative herbal medicine that has been widely used for patients with obesity in east Asian countries. Various preclinical studies have demonstrated the anti-depressive effect of BTS granules in various animal models of depression. This phase II trial aimed to explore the efficacy and safety of BTS in human patients with depression.

Methods
A total of 126 patients diagnosed with major depressive disorder and who are not underweight (body mass index ≥ 18.5 kg/m2) will be enrolled in this study. Eligible participants will be randomly allocated into three groups: the high-dose BTS, low-dose BTS, and placebo groups in a 1:1:1 ratio. BTS or placebo granules will be orally administered twice a day for 8 weeks. The BTS and placebo granules will be made to have identical color, scent, and shape, and participants and investigators will be blinded to the allocation. The primary efficacy endpoint is the change from baseline of the 17-item Hamilton Depression Rating Scale total score at 8 weeks. The superiority of the high- and low-dose BTS granules to the placebo granules will be tested.

Discussion
The results of this clinical trial will provide evidence on the efficacy and safety of BTS for patients with major depressive disorder. This study will be conducted in accordance with ethical and regulatory guidelines, and the results will be submitted and published in international peer-reviewed journals.

Trial registration
CRIS registration Number: KCT0007571; registered on 2022/07/26 (https://cris.nih.go.kr/cris/search/detailSearch.do/23192).
Exploring medical students’ perceptions of family medicine in Kyrgyzstan: a mixed method study
Authors: Heller Olivia , Ismailova Zhyldyz , Mambetalieva Damira , Brimkulov Nurlan , Beran David , Nendaz Mathieu , Vu Nu V. , Loutan Louis , Baroffio Anne 
Published: April 2023

Abstract
Background
Despite knowing that health systems with strong primary care improve overall health outcomes within a population, many countries are facing a global trend of declining interest and shortage of family doctors. This is the case of the Kyrgyz Republic, in which rural areas are struggling to attract and retain family medicine (FM) doctors. This study aims to explore how Kyrgyz medical students perceive FM and the factors that influence their specialty choice.

Methods
This study used a cross-sectional explanatory sequential design, including quantitative survey and focus group discussions that were carried out at the Kyrgyz State Medical Academy (KSMA) in Bishkek in 2017. Overall, 66% (953 out of 1449) of medical undergraduate students registered in year 1, 4 and 6 completed the survey, and 42 participated in the focus groups. The results were organized around 7 factors influencing perceptions and attitudes towards FM identified through a qualitative systematic review.

Results
The interest of Kyrgyz students for FM was the lowest of all specialties. Access to high medical technologies, career opportunities, salary, patient interaction and possibility to work abroad were the five most important factors influencing specialty choice. FM was perceived as a difficult profession, yet with poor prestige, insufficient remuneration, limited career possibilities and poor working conditions, especially in rural areas. The academic discourse, which disregards FM specialty had a negative influence on student’s perceptions and prevented students’ ability to identify with the practice of family medicine. However, students’ awareness of their social accountability arose as a positive leverage to increase the choice of FM, provided other problems were solved.

Conclusion
This study highlighted key factors responsible for the low number of students choosing to become FM in Kyrgyzstan. The first major factor, presumably specific to many low- and lower-middle- income countries was the poor working conditions in remote areas. The second factor, common to many countries, was the distorted image of FM and its specialty transmitted through the medical schools’ institutional culture which does not value FM through positive role models. This study served as a basis to establish a strategy to promote FM within the KSMA and potentially at National level.
Objective structured clinical examination as a competency assessment tool of students’ readiness for advanced pharmacy practice experiences in South Korea: a pilot study
Authors: Song Yun-Kyoung , Chung Eun Kyoung , Lee Young Sook , Yoon Jeong-Hyun , Kim Hyunah 
Published: April 2023

Abstract
Background
The assessment of pharmacy students’ readiness to begin the education of an advanced pharmacy practice experience (APPE) in clinical pharmacy settings continues to gain increasing attention. This study aimed to develop an objective structured clinical examination (OSCE) in the core domains acquired through an introductory pharmacy practice experience (IPPE), for evaluating its appropriateness as a tool of assessing clinical pharmacist competency for APPEs in Korean pharmacy students throughout a pilot study.

Methods
OSCE’s core competency domains and case scenarios were developed through a literature review, ideation by researchers, and external experts’ consensus by a Delphi method. A prospective single-arm pilot test was conducted to implement the OSCE for Korean pharmacy students who completed a 60-h course of in-class simulation IPPE. Their competencies were assessed by four assessors in each OSCE station with a pass-fail grading system accompanied by a scoring rubric.

Results
OSCE competency areas including patient counseling, provision of drug information, over-the-counter (OTC) counseling, and pharmaceutical care services were developed with four interactive and one non-interactive cases. Twenty pharmacy students participated in the OSCE pilot test, and their competencies were evaluated by 20 assessors. The performance rate was the lowest in the area of patient counseling for a respiratory inhaler (32.1%) and the highest (79.7%) in OTC counseling for constipation. The students had an average performance rate of 60.4% in their communication skills. Most participants agreed on the appropriateness, necessity, and effectiveness of the OSCE in evaluating pharmacy students’ clinical performance and communication skills.

Conclusions
The OSCE model can be used to assess pharmacy students’ readiness for off-campus clinical pharmacy practice experience. Our pilot study suggests the necessity of conducting an OSCE domain-based adjustment of difficulty levels, and strengthening simulation-based IPPE education.
Descriptive study: the novel “full spectrum people-with-opioid-use-disorder care model”
Authors: Gadomski Richard , Bhatt Snehal , Gross Jessica , Dixon Juan Antonio , Fiuty Phillip , Shapiro Max , Fernandez-Mancha Rafael , Salvador Julie 
Published: April 2023

Abstract
Background
People with Opioid Use Disorder (PWOUD) represent an underserved and marginalized population for whom treatment gaps exist. Low-barrier programs like mobile care units and street outreach programs have yielded increased access to buprenorphine and social services, however, OUD pertinent co-occurring behavioral health and medical conditions are frequently left unaddressed. A novel, tailored, comprehensive care delivery model may reduce disparities and improve access to care across a range of pathologies in this historically difficult to reach population and enhance efforts to provide universal treatment access in a harm reduction setting.

Methods
Descriptive data were collected and analyzed regarding patient demographics, retention in treatment and services rendered at a new, wrap-around, low-barrier buprenorphine clinic established at an existing harm reduction site in New Mexico between August 1, 2020, and August 31, 2021.

Results
203 people used any service at the newly implemented program, 137 of whom specifically obtained medical and/or behavioral health care services including prescriptions for buprenorphine at least once from the physician onsite. Thirty-seven unique medical and psychiatric conditions were treated, representing a total of 565 separate encounters. The most common service utilized was buprenorphine treatment for opioid use disorder (81%), followed by treatment for post-traumatic stress disorder (62%), anxiety (44.5%) and depression (40.9%). Retention in buprenorphine treatment was 31.2% at 6 months.

Conclusions
An innovative, multidisciplinary, buprenorphine-centric care model, which targets a wide range of OUD pertinent pathologies while employing a harm reduction approach, can enhance utilization of these services among an underserved PWOUD population in a manner which moves our health system toward universal OUD treatment access thereby potentially reducing overdose and existing disparities.