bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleaginous yeast, Rhodotorula paludigena CM33, platform for bio-oil and biochar productions via fast pyrolysis
Authors: Poopisut Pongsatorn , Boonyanan Pasama , Boontawan Pailin , Sukjit Ekarong , Promsampao Nuttapan , Chollacoop Nuwong , Ketudat-Cairns Mariena , Pattiya Adisak , Boontawan Apichat 
Published: February 2023

AbstractAn oleaginous yeast Rhodotorula paludigena CM33 was pyrolyzed for the first time to produce bio-oil and biochar applying a bench-scale reactor. The strain possessed a high lipid content with the main fatty acids similar to vegetable oils. Prior to pyrolysis, the yeast was dehydrated using a spray dryer. Pyrolysis temperatures in the range of 400–600 °C were explored in order to obtain the optimal condition for bio-oil and biochar production. The result showed that a maximum bio-oil yield of 60% was achieved at 550 °C. Simulated distillation gas chromatography showed that the bio-oil contained 2.6% heavy naphtha, 20.7% kerosene, 24.3% biodiesel, and 52.4% fuel oil. Moreover, a short path distillation technique was attempted in order to further purify the bio-oil. The biochar was also characterized for its properties. The consequence of this work could pave a way for the sustainable production of solid and liquid biofuel products from the oleaginous yeast.
Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature
Authors: Allahyari Abolghasem , Maharati Amirhosein , Jafari-Nozad Amir Masoud , zangooie Alireza 
Published: February 2023

Abstract
Background
Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage. The coexistence of CML and MM that is a rare phenomenon, with only 29 cases reported in the literature. To the best of our, this combination of triple primary cancers has not been reported in a single patient.

Case presentation
Herein, we reported a case of an 85-year-old Iranian male with three confirmed primary malignant neoplasms. The patient presented with synchronous prostate cancer and CML, in august 2016. He received imatinib and nilotinib for CML and hormonal therapy for prostate cancer. He remained in good control at further follow-ups for about 5 years. In the follow-up period and after 61 months treatment with tyrosine kinase inhibitors (TKIs), CML was undetectable in molecular tests, but the presence of serum M-protein, abnormal plasma cells in the bone marrow, and CRAB criteria was compatible with MM.

Conclusion
We must evaluate the possibility of multiple primary cancers during cancer treatment and follow-up and it may be worthwhile to monitor serum electrophoresis and protein levels in TKIs-treated patients.
A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders
Authors: Jones Brett D. M. , Umer Madeha , Kittur Mary E. , Finkelstein Ofer , Xue Siqi , Dimick Mikaela K. , Ortiz Abigail , Goldstein Benjamin I. , Mulsant Benoit H. , Husain Muhammad I. 
Published: February 2023

Abstract
Background
Evidence-based psychotherapies available to treat patients with bipolar disorders (BD) are limited. Dialectical behavior therapy (DBT) may target several common symptoms of BD. We conducted a systematic review on the efficacy of DBT for mood symptoms in patients with BD. The systematic search used key words related to DBT and BD in Medline, Embase, PsycInfo, CINAHL, and Cochrane Library databases from 1980 to April 1st, 2022. We included studies that enrolled patients with a BD I or II diagnosis (DSM or ICD), age 12 and older who received a DBT-based intervention. Studies reviewed were clinical trials including observational studies that reported at least one outcome related to BD mood symptoms or severity. We did not exclude based upon psychiatric or physical co-morbidity.

Results
We screened 848 abstracts and reviewed 28 full texts; 10 publications with 11 studies met our pre-determined eligibility criteria. All but one were feasibility pilot studies and most included participants in all mood states except for mania. The studies provided preliminary evidence suggesting these interventions may be effective for improving several core symptoms of BD. Overall, all the studies consistently supported that DBT-based interventions are feasible and acceptable for patients with BD.

Conclusion
DBT may be an effective treatment for BD; however, the confidence in this conclusion is limited by the small sample sizes, heterogeneity, and high risk of bias in all published trials. Larger well-designed RCTs are now required to establish the effectiveness of DBT in BD.
Analysing the impact of contextual segments on the overall rating in multi-criteria recommender systems
Authors: Krishna Chinta Venkata Murali , Rao G. Appa , Anuradha S. 
Published: February 2023

AbstractDepending on the RMSE and sites sharing travel details, enormous reviews have been posted day by day. In order to recognize potential target customers in a quick and effective manner, hotels are necessary to establish a customer recommender system. The data adopted in this study was rendered by the Trip Advisor which permits the customers to rate the hotel on the basis of six criteria such as, Service, Sleep Quality, Value, Location, Cleanliness and Room. This study suggest the multi-criteria recommender system to analyse the impact of contextual segments on the overall rating based on trip type and hotel classes. In this research we have introduced item-item collaborative filtering approach. Here, the adjusted cosine similarity measure is applied to identify the missing value for context in the dataset. For the selection of significant contexts the backward elimination with multi regression algorithm is introduced. The multi-collinearity among predictors is examined on the basis of Variance Inflation Factor (V.I.F). In the experimental scenario, the results are rendered based on hotel class and trip type. The performance of the multiregression model is evaluated by the statistical measures such as R-square, MAE, MSE and RMSE. Along with this, the ANOVA study is conducted for different hotel classes and trip types under 2, 3, 4 and 5 star hotel classes.
IGRF-RFE: a hybrid feature selection method for MLP-based network intrusion detection on UNSW-NB15 dataset
Authors: Yin Yuhua , Jang-Jaccard Julian , Xu Wen , Singh Amardeep , Zhu Jinting , Sabrina Fariza , Kwak Jin 
Published: February 2023

AbstractThe effectiveness of machine learning models can be significantly averse to redundant and irrelevant features present in the large dataset which can cause drastic performance degradation. This paper proposes IGRF-RFE: a hybrid feature selection method tasked for multi-class network anomalies using a multilayer perceptron (MLP) network. IGRF-RFE exploits the qualities of both a filter method for its speed and a wrapper method for its relevance search. In the first phase of our approach, we use a combination of two filter methods, information gain (IG) and random forest (RF) respectively, to reduce the feature subset search space. By combining these two filter methods, the influence of less important features but with the high-frequency values selected by IG is more effectively managed by RF resulting in more relevant features to be included in the feature subset search space. In the second phase of our approach, we use a machine learning-based wrapper method that provides a recursive feature elimination (RFE) to further reduce feature dimensions while taking into account the relevance of similar features. Our experimental results obtained based on the UNSW-NB15 dataset confirmed that our proposed method can improve the accuracy of anomaly detection as it can select more relevant features while reducing the feature space. The results show that the feature is reduced from 42 to 23 while the multi-classification accuracy of MLP is improved from 82.25% to 84.24%.
Engineering design learning for high school and college first-year students in a STEM battlebot design project
Authors: Chien Yu-Hung , Liu Chia-Yu , Chan Shaio-Chung , Chang Yu-Shan 
Published: February 2023

Abstract
Background
There is a worldwide trend to include engineering design in high school curricula as a bridge course to higher-level STEM education and to increase high school students’ interest in STEM fields. This study used a battlebot design curriculum to compare engineering design learning between high school and college first-year students and then proposed suggestions for curriculum planning that promoted the continuity of learning between different levels of engineering design education.

Results
This study used the creative product analysis matrix (CPAM) and lag sequential analysis (LSA) to explore the possible similarities and differences between the two groups’ understanding of engineering design. The results show that college first-year students were significantly better than high school students in CPAM, but the two groups were similar in their reflections on engineering design behaviors, indicating that the noncumulative learning results must be taken seriously.

Conclusions
Higher-order engineering design thinking skills take a longer time to develop than technical skills. For both high school and college first-year students, it is important to enhance their higher-order engineering design thinking skills to promote higher engineering design performance. Moreover, high school students could be provided with convenient processing tools and easy-to-use, hands-on techniques to increase their technical skills. Educators from institutions of higher education and K-12 schools should work together to develop pedagogical models that provide rigorous, well-rounded education and outstanding engineering design instructions to most effectively cultivate STEM talent.
Application of environmental-safe fermentation with Saccharomyces cerevisiae for increasing the cinnamon biological activities
Authors: Darwesh Osama M. , Eweys Aya S. , Zhao Yan-Sheng , Matter Ibrahim A. 
Published: February 2023

AbstractThe effect of fermentation by Saccharomyces cerevisiae on biological properties of cinnamon (Cinnamomum cassia) was investigated. The study demonstrated that the extract of S. cerevisiae-fermented cinnamon (S.C.FC) has antioxidants higher than non-fermented one. The optimum results for antioxidant yield were noted with 107 CFU S. cerevisiae/10 g cinnamon and 70 mL of dH2O at pH 6 and incubated for 3 d at 35 °C. Under optimum conditions, ABTS, DPPH, and H2O2 radical-scavenging activity increased by 43.8, 61.5, and 71.9%, respectively. Additionally, the total phenols and flavonoids in S.C.FC were increased by 81.3 and 415% compared by non-fermented one. The fermented cinnamon had antimicrobial activity against L. monocytogenes, S. aureus, E. coli, S. typhi, and C. albicans. Also, the anti-inflammatory properties were increased from 89 to 92% after fermentation. The lyophilized extract of S.C.FC showed positive effect against Huh7 cancer cells which decreased by 31% at the concentration of 700 µg/mL. According to HPLC analysis, p-hydroxybenzoic acid, gentisic acid, catechin, chlorogenic acid, caffeic acid, and syringic acid were increased by 116, 33.2, 59.6, 50.6, 1.6, and 16.9%, respectively. Our findings suggest the applicability of cinnamon fermentation using S. cerevisiae as a useful tool for processing functional foods to increase their antioxidant and anti-inflammatory content.
Graphical Abstract
How online shopping festival atmosphere promotes consumer participation in China
Authors: Xie Jiali , Yoon Namhee , Choo Ho Jung 
Published: February 2023

AbstractDespite the immense success of China’s Double Eleven online shopping festival (OSF), research on how OSFs’ unique atmosphere relates to customer behavior has been scarce. This study investigates the influence of the OSF atmosphere on consumers’ participation behavior based on the stimulus–organism–response framework. Based on the data from 239 young Chinese consumers (in their 20 s and 30 s) and using structural equation modeling, this study explores the influence of three OSF atmosphere types—promotional, entertaining, and social interaction—on consumers’ continuous participation intention. All three types are found to influence consumers’ excitement, which strengthens their continuous participation intention. Additionally, the moderating effect of perceived time pressure is the highest for the relationship between entertaining atmosphere and excitement, followed by that between social interaction atmosphere and excitement. The greater the time pressure perceived by consumers, the stronger is the relationship between entertaining/social interaction atmosphere and excitement. This study bridges the gaps in the literature on atmosphere, consumer sentiment, and festival consumption.
Hard and soft tissue regeneration of severe peri-implantitis defects with the laser-assisted peri-implant defect regeneration technique: 3-year results
Authors: Noelken Robert , Westphal Laura , Schiegnitz Eik , Al-Nawas Bilal 
Published: February 2023

AbstractPurposeThis retrospective cohort study evaluates the regeneration of severe peri-implantitis deficiencies treated with the laser-assisted peri-implant defect regeneration (LAPIDER) approach within a 3-year follow-up.MethodsTwenty-four implants with severe peri-implantitis in 18 patients were treated according to the LAPIDER technique. In contrast to classic techniques for reconstructive peri-implantitis surgery with a marginal incision, a buccal split-flap preparation avoiding papillae separation was used. After a coronal flap elevation and a laser-assisted peri-implant defect cleaning, connective tissue and autogenous bone grafting was performed. Primary outcomes were the changes of the marginal bone levels (MBL) and the buccal bone thickness. Secondary outcomes included implant survival, peri-implant probing depths (PPD), bleeding on probing (BOP), recession, width of keratinized mucosa (KMW), thickness of keratinized mucosa (KMT), soft tissue esthetics (PES), and implant success.ResultsMBL improved interproximal by 3.10 ± 2.02 mm (p < 0.001), buccal by 3.49 ± 2.89 mm (p < 0.001), and lingual by 1.46 ± 1.98 mm (p = 0.003); buccal bone thickness by 0.55 ± 0.60 mm (p = 0.005), and 1.01 ± 1.25 mm (p = 0.001) at 1 and 3 mm below reference level. Two implants were removed; 22 implants were still in function at a mean follow-up of 36 months. PPD changed from 5.05 ± 1.39 to 3.08 ± 0.71 mm (p < 0.001); recession was reduced from 2.07 ± 1.70 to 0.91 ± 1.13 mm (p = 0.001); KMW increased from 2.91 ± 1.81 to 4.18 ± 1.67 mm (p = 0.006); KMT improved from 1.73 ± 0.50 to 2.44 ± 0.43 mm (p < 0.001); PES changed from 7.7 ± 2.8 to 10.7 ± 1.9 (p < 0.001). 45.8% to 54.2% of the implants met the criteria of implant success.ConclusionsThe favorable results document the proof of principle for the regeneration of severe peri-implant hard and soft tissue deficiencies by the LAPIDER treatment approach.
Hierarchical porous ECM scaffolds incorporating GDF-5 fabricated by cryogenic 3D printing to promote articular cartilage regeneration
Authors: Wu Jiang , Fu Liwei , Yan Zineng , Yang Yu , Yin Han , Li Pinxue , Yuan Xun , Ding Zhengang , Kang Teng , Tian Zhuang , Liao Zhiyao , Tian Guangzhao , Ning Chao , Li Yuguo , Sui Xiang , Chen Mingxue , Liu Shuyun , Guo Quanyi 
Published: February 2023

Abstract

Background
In recent years, there has been significant research progress on in situ articular cartilage (AC) tissue engineering with endogenous stem cells, which uses biological materials or bioactive factors to improve the regeneration microenvironment and recruit more endogenous stem cells from the joint cavity to the defect area to promote cartilage regeneration.

Method
In this study, we used ECM alone as a bioink in low-temperature deposition manufacturing (LDM) 3D printing and then successfully fabricated a hierarchical porous ECM scaffold incorporating GDF-5.

Results
Comparative in vitro experiments showed that the 7% ECM scaffolds had the best biocompatibility. After the addition of GDF-5 protein, the ECM scaffolds significantly improved bone marrow mesenchymal stem cell (BMSC) migration and chondrogenic differentiation. Most importantly, the in vivo results showed that the ECM/GDF-5 scaffold significantly enhanced in situ cartilage repair.

Conclusion
In conclusion, this study reports the construction of a new scaffold based on the concept of in situ regeneration, and we believe that our findings will provide a new treatment strategy for AC defect repair.
Pulse oximetry: why oxygen saturation is still not a part of standard pediatric guidelines in low-and-middle-income countries (LMICs)
Authors: Sheikh Maheen , Ahmad Huzaifa , Ibrahim Romesa , Nisar Imran , Jehan Fyezah 
Published: February 2023

Abstract
Background
With the high frequency of acute respiratory infections in children worldwide, particularly so in low-resource countries, the development of effective diagnostic support is crucial. While pulse oximetry has been found to be an acceptable method of hypoxemia detection, improving clinical decision making and efficient referral, many healthcare set ups in low- and middle-income countries have not been able to implement pulse oximetry into their practice.

Main body
A review of past pulse oximetry implementation attempts in low- and middle-income countries proposes the barriers and potential solutions for complete integration in the healthcare systems. The addition of pulse oximetry into WHO health guidelines would prove to improve detection of respiratory distress and ensuing therapeutic measures. Incorporation is limited by the cost and unavailability of pulse oximeters, and subsequent oxygen accessibility. This restriction is compounded by the lack of trained personnel, and healthcare provider misconceptions. These hurdles can be combated by focus on low-cost devices, and cooperation at national levels for development in healthcare infrastructure, resource transport, and oxygen delivery systems.

Conclusion
The implementation of pulse oximetry shows promise to improve child morbidity and mortality from pneumonia in low- and middle-income countries. Steady measures taken to improve access to pulse oximeters and oxygen supplies, along with enhanced medical provider training are encouraging steps to thorough pulse oximetry integration.
Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy
Authors: Jaber Sara , Warnier Marine , Leers Christopher , Vernier Mathieu , Goehrig Delphine , Médard Jean-Jacques , Vindrieux David , Ziegler Dorian V. , Bernard David 
Published: February 2023

AbstractPancreatic cancer is one of the deadliest cancers owing to its late diagnosis and of the strong resistance to available treatments. Despite a better understanding of the disease in the last two decades, no significant improvement in patient care has been made. Senescent cells are characterized by a stable proliferation arrest and some resistance to cell death. Increasing evidence suggests that multiple lines of antitumor therapy can induce a senescent-like phenotype in cancer cells, which may participate in treatment resistance. In this study, we describe that gemcitabine, a clinically-used drug against pancreatic cancer, induces a senescent-like phenotype in highly chemoresistant pancreatic cancer cells in vitro and in xenografted tumors in vivo. The use of ABT-263, a well-described senolytic compound targeting Bcl2 anti-apoptotic proteins, killed pancreatic gemcitabine-treated senescent-like cancer cells in vitro. In vivo, the combination of gemcitabine and ABT-263 decreased tumor growth, whereas their individual administration had no effect. Together these data highlight the possibility of improving the efficacy of conventional chemotherapies against pancreatic cancer by eliminating senescent-like cancer cells through senolytic intervention. Further studies testing different senolytics or their combination with available treatments will be necessary to optimize preclinical data in mouse models before transferring these findings to clinical trials.
The laboratory journey to become a decision engine: a roadmap for diagnostic transformation
Authors: Lange Florian 
Published: February 2023

Abstract
Laboratories and diagnostic departments are presiding over a massive amount of data they are failing to fully leverage it. Data is the new black gold of healthcare organizations and by extracting insights from it, laboratories could become true decision engines, able to drive action across healthcare. This opinion paper responds three fundamental questions: (1) Where are we (diagnostic parties)? Taking a look at the most significant trends and challenges in healthcare and shedding some light upon the status of diagnostics. (2) Where do we want to be? Reviewing the opportunities for digital health, its role in the healthcare of the future and providing inspiration about what success looks like. (3) What do we need to do? Explaining what Digital Health Solutions (DHS) from Abbott is doing in this regard. This will include information about how DHS can impact the Diagnosis Cycle and how to set a roadmap for laboratories and diagnostic organizations. Diagnosis Cycle means the different steps in the diagnosis process, from the beginning when a patient is seen by a clinician and some tests are ordered, until the results are reviewed by the clinician and the treatment, follow up or discharge is decided.
Sobre la mirada decolonial de Mía Gallegos: Apuntes sobre Una mirada decolonial en torno a la novela Limón Blues
Authors: Solórzano-Castillo Alejandra 
Published: February 2023

La autora Mía Gallegos nos ofrece varias coordenadas para emprender el camino de reflexión sobre Limón Blues de Anacristina Rossi. La primera es el análisis de/colonial, abiertamente expuesto como motor de su reflexión; la otra, que suma a la mirada decolonial, es la del análisis interseccional. Gallegos hilvana el análisis retrospectivo de las racionalizaciones y justificaciones del binomio modernidad/colonialidad y de las ramificaciones dicotómicas de poder, sostenidas en las categorías mentales propias de la colonialidad para mostrarnos cómo estas delinean los personajes de la novela de Rossi en el marco de su dimensión histórica, política, social, identitaria y de género. La interseccionalidad refiere, por su lado, al entrecruzamiento macro de las novelas Limón Blues de Rossi y Orlandus, de Virginia Woolf, para dar por resultado un exquisito ensayo crítico de una de las escritoras contemporáneas más importantes de Costa Rica.
Costa Rica: El papel del Estado frente al femicidio
Authors: Barrera-Rivera Abner , Castillo-Rojas Mariana 
Published: February 2023

Abordar el papel del Estado costarricense frente al femicidio requiere examinar las medidas tomadas por los gobiernos, sus obligaciones normativas y su traducción en políticas públicas, para garantizar la protección y la vivencia plena de los derechos humanos de las mujeres. Este artículo hace un recorrido por las principales normativas y acciones del Estado, poniendo especial énfasis a las acciones en el ámbito de la educación