bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis prediction of uterine cervical cancer using changes in the histogram and texture features of apparent diffusion coefficient during definitive chemoradiotherapy
Authors: Takada Akiyo , Yokota Hajime , Nemoto Miho Watanabe , Horikoshi Takuro , Matsumoto Koji , Habu Yuji , Usui Hirokazu , Nasu Katsuhiro , Shozu Makio , Uno Takashi 
Published: March 2023

Objectives
We investigated prospectively whether, in cervical cancer (CC) treated with concurrent chemoradiotherapy (CCRT), the Apparent diffusion coefficient (ADC) histogram and texture parameters and their change rates during treatment could predict prognosis.

Methods
Fifty-seven CC patients treated with CCRT at our institution were included. They underwent MRI scans up to four times during the treatment course (1st, before treatment [n = 41], 2nd, at the start of image-guided brachytherapy (IGBT) [n = 41], 3rd, in the middle of IGBT [n = 27], 4th, after treatment [n = 53]). The entire tumor was manually set as the volume of interest (VOI) manually in the axial images of the ADC map by two radiologists. A total of 107 image features (morphology features 14, histogram features 18, texture features 75) were extracted from the VOI. The recurrence prediction values of the features and their change rates were evaluated by Receiver operating characteristics (ROC) analysis. The presence or absence of local and distant recurrence within two years was set as an outcome. The intraclass correlation coefficient (ICC) was also calculated.

Results
The change rates in kurtosis between the 1st and 3rd, and 1st and 2nd MRIs, and the change rate in grey level co-occurrence matrix_cluster shade between the 2nd and 3rd MRIs showed particularly high predictive powers (area under the ROC curve = 0.785, 0.759, and 0.750, respectively), which exceeded the predictive abilities of the parameters obtained from pre- or post-treatment MRI only. The change rate in kurtosis between the 1st and 2nd MRIs had good reliability (ICC = 0.765).

Conclusions
The change rate in ADC kurtosis between the 1st and 2nd MRIs was the most reliable parameter, enabling us to predict prognosis early in the treatment course.
Effect of ’Kuat’ a theory- and web-based health education intervention on mental health literacy among university students: A study protocol
Authors: Zulkiply Siti Hafizah , Abdul Manaf Rosliza , Dahlan Rahima , Dapari Rahmat 
Published: March 2023

Background
Mental health problems, particularly depression and anxiety disorders are the leading causes of disease burden. Despite the effectiveness of mental healthcare services and the impairing effects of untreated mental health problems, the rate of help-seeking is low among young people. In addition, the mental health burden gap is high in low- and middle-income countries. Good mental health literacy has been associated with better help-seeking.

Aims
This study aims to evaluate the effect of theory- and web-based health education intervention on mental health literacy among foundation students at a public university in Malaysia.

Methods
A randomised controlled trial study will be conducted among foundation students. Participants will be recruited and randomly assigned to either the intervention or control group. The intervention will be conducted for two weeks with a one-month follow-up. The health education intervention will be developed according to the Information, Motivation, and Behavioural Skill Theory, and will be delivered via a website. The outcome will be measured using validated, self-administered questionnaires. at baseline, post-intervention, and one-month follow up. The data will be analysed using Generalised Estimating Equation (GEE). This study is registered to the Thai Clinical Trial Registry (TCTR) (reference number: TCTR20210705006), dated 4th July 2021.

Conclusions
The results from this study will be useful for relevant authorities to take further efforts in mental health promotion among young people.
The histological analysis of the coronary medial thickness: Implications for percutaneous coronary intervention
Authors: Konishi Takao , Ghosh Saikat Kumar B. , Sato Yu , Kawakami Rika , Kawai Kenji , Vozenilek Aimee E. , Xu Weili , Bellissard Arielle , Giasolli Robert , Chahal Diljon , Virmani Renu , Finn Aloke V. 
Published: March 2023

Background
A deeper understanding of coronary medial thickness is important for coronary intervention because media thickness can limit the safety and effectiveness of interventional techniques. However, there is a paucity of detailed data on human coronary medial thickness so far.

Materials and methods
We investigated the thickness of the media by histologic analysis. A total of 230 sections from 10 individuals from the CVPath autopsy registry who died from non-coronary deaths were evaluated. We performed pathological analysis on 13 segments of the following primary vessels from coronary arteries: the left main trunk, proximal left anterior descending artery (LAD), mid LAD, distal LAD, proximal left circumflex artery (LCX), mid LCX, distal LCX, proximal right coronary artery (RCA), mid RCA, and the distal RCA. The following side branches were also evaluated: diagonal, obtuse margin, and posterior descending artery branches.

Results
The average age of the studied individuals was 60.4±12.3 years. The median medial thickness for all sections was 0.202 (0.149–0.263) mm. The median medial thickness of the main branches was significantly higher compared to that of the side branches (p<0.001). Although the medial thicknesses of the main branch of LAD and LCX were significantly decreased from proximal to distal segments (p = 0.010, p = 0.006, respectively), the medial thickness of the main branch of RCA was not significantly decreased from proximal to distal (p = 0.170). The thickness of the media was positively correlated with vessel diameter, while it was negatively correlated with luminal narrowing (p<0.001 and p<0.001, respectively).

Conclusions
The human coronary arteries demonstrate variation in medial thickness which tends to vary depending upon an epicardial coronary artery itself, as well as its segments and branches. Understanding these variations in medial thickness can be useful for both the interventionalists and interventional product development teams.
Everything Has a Role to Play: Reconstruction of Vessel Function From Early Copper Age Graves in the Upper Tisza Region (Eastern Hungary)
Authors: Solnay Eszter 
Published: March 2023

Abstract
Investigation into the utilitarian function of mortuary vessels is often a neglected aspect of ceramic examination. Since, in most cases, a direct link can be assumed between the vessels’ size, form, and most optimal utilitarian function, morphometry-based ceramic categories – along with ethnoarchaeological examples – can help to understand the role of these vessels in funerary contexts. This article focuses on the relationship between the utilitarian function of ceramics and their roles in graves through the analysis of eight Early Copper Age (4400/4300–4000/3900 BC) burial sites, associated with Tiszapolgár and Bodrogkeresztúr ceramic styles, from the Upper Tisza Region (Hungary). The deposition of ceramic assemblages in graves became common in this period; however, a systematic analysis of their function has never been carried out before. In this study, a morphometry-based methodology was developed to establish the vessels’ utilitarian function. These functions were considered in the analysis of the composition of mortuary assemblages, and how they may reflect social status or gender roles of the deceased individual. Results indicate that the Tiszapolgár and Bodrogkeresztúr assemblages cannot be unequivocally distinguished from each other based on morphometric and functional criteria, suggesting similar functional roles in the past funerary contexts.
M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus
Authors: Conde-Berriozabal Sara , García-Gilabert Lia , García-García Esther , Sitjà-Roqueta Laia , López-Gil Xavier , Muñoz-Moreno Emma , Boutagouga Boudjadja Mehdi , Soria Guadalupe , Rodríguez Manuel J , Alberch Jordi , Masana Mercè 
Published: March 2023

Early and progressive cortico-striatal circuit alterations have been widely characterized in Huntington's disease (HD) patients. Cortical premotor area, M2 cortex in rodents, is the most affected cortical input to the striatum from early stages in patients and is associated to the motor learning deficits present in HD mice. Yet, M2 cortex sends additional long-range axon collaterals to diverse output brain regions beyond basal ganglia. Here, we aimed to elucidate the contribution of M2 cortex projections to HD pathophysiology in mice. Using fMRI, M2 cortex showed most prominent functional connectivity alterations with the superior colliculus (SC) in symptomaticR6/1HD male mice. Structural alterations were also detected by tractography, although diffusion weighted imaging measurements suggested preserved SC structure and similar electrophysiological responses were obtained in the SC on optogenetic stimulation of M2 cortical axons. Male and female HD mice showed behavioral alterations linked to SC function, including decreased defensive behavioral responses toward unexpected stimuli, such as a moving robo-beetle, and decreased locomotion on an unexpected flash of light. Additionally, GCamp6f fluorescence recordings with fiber photometry showed that M2 cortex activity was engaged by the presence of a randomly moving robo-bettle, an effect absent in HD male mice. Moreover, acute chemogenetic M2 cortex inhibition in WT mice shift behavioral responses toward an HD phenotype. Collectively, our findings highlight the involvement of M2 cortex activity in visual stimuli-induced behavioral responses, which are deeply altered in theR6/1HD mouse model.SIGNIFICANCE STATEMENTUnderstanding brain circuit alterations in brain disorders is critical for developing circuit-based therapeutic interventions. The cortico-striatal circuit is the most prominently disturbed in Huntington's disease (HD); and particularly, M2 cortex has a prominent role. However, the same M2 cortical neurons send additional projections to several brain regions beyond striatum. We characterized new structural and functional circuitry alterations of M2 cortex in HD mouse models and found that M2 cortex projection to the superior colliculus (SC) was deeply impaired. Moreover, we describe differential responses to unexpected sensory stimulus in HD mouse models, which relies on SC function. Our data highlight the involvement of M2 cortex in SC-dependent sensory processing and its alterations in HD pathophysiology.
Endoscopic Ultrasound-guided Trans-esophageal Transmural Drainage of Mediastinal Pseudocysts: A Case Series
Authors: Rana Surinder Singh , Choudhary Arup , Jha Daya Krishna , Kumar Pankaj , Gupta Rajesh 
Published: March 2023

Background and Aims: Mediastinal pseudocysts (MP) are rare, and surgery is the conventional treatment modality. However, in the last decade, excellent outcomes have been reported with endoscopic transpapillary drainage. Endoscopic ultrasound (EUS) guided trans-esophageal transmural drainage of MP is a minimally invasive and effective non-surgical treatment modality, but the experience is limited. We aimed to report our experience of EUS-guided transmural drainage in 10 patients with MP‘s.
Methods: A retrospective analysis of patients with pancreatic fluid collections treated with EUS-guided transmural drainage over the last ten years was completed to to identify patients with MP‘s.
Results: Ten patients (8 males, with a mean age of 34.9±9.17 years) with MP treated with EUS-guided transesophageal transmural drainage were identified. Nine patients with MP had concurrent chronic pancreatitis, and only one had MP following acute necrotizing pancreatitis. The mean size of MP was 5.70±1.64 cm, and nine patients (90%) had concurrent abdominal pseudocyst. EUS-guided transesophageal transmural drainage was technically successful in all ten patients. Transmural plastic stents were placed in 9 patients, whereas one patient underwent single-time complete aspiration of the MP. There were no immediate or delayed procedure-related complications. All ten patients had a successful outcome, with the mean resolution time being 2.80±0.79 weeks. There has been no recurrence of PFC or symptoms in nine (90%) successfully treated patients over a mean follow-up period of 43.3 months.
Conclusions: EUS-guided trans-esophageal drainage of MP is safe with a high technical and clinical success rate.
Вплив цифровізації на державне управління у сфері протидії міжнаціональним конфліктам
Authors: Квітка Сергій , Карпенко Олександр 
Published: March 2023

Мета дослідження полягає у визначенні основних аспектів і напрямків впливу цифровізації на механізми державного управління у сфері протидії міжнаціональним та міжконфесійним конфліктам у суспільстві. Враховується, що важливими чинниками виникнення міжнаціональних конфліктів є втрата людьми, в умовах всебічної цифровізації суспільства, своєї національної та соціальної індентифікації.
Визначено, що у цьому контексті особливого значення набувають викликані цифровою трансформацією зміни консолідуючих ціннісних орієнтацій суспільства, зокрема, зрушення у поведінковій і ціннісній сферах, що передусім характерні для країн, що більше інших просунулись у сфері цифровізації і, очевидно, неминучі і для держав інших країн які у міру сил впроваджують новітні цифрові технології.
Зазначені тенденції закономірно розмили рівень соціального капіталу та довіри у суспільстві, значення якого для гармонійного та стабільного соціально-економічного та політичного розвитку складно переоцінити. При цьому в розвинених країнах становище ускладняється тим, що в державах ліберального Заходу політика ідентичності, як правило, інтерпретується в негативних категоріях, розглядається не як інструмент консолідації та гармонізації суспільства, а як причина соціальних і міжнаціональних конфліктів.
Зазначається, що в умовах інтенсивного формування нового, «цифрового» простору, на тлі повсюдного впровадження цифрових технологій у різні сфери життя, соціальні процеси розвиваються дуже стрімко, а то й сказати стихійно, що ускладнює здатність держави передбачати несприятливі події. Особливу небезпеку становлять прояви міжнаціональної напруженості, що зароджуються і в лічені дні розповсюджуються в Інтернеті, а потім переростають у повноцінні конфлікти.
Робиться висновок, що ринкові механізми і цифрові технології самі по собі не вирішують численних проблем, що стоять перед сучасним суспільством. Ефективні рішення можливі лише на рівні скоординованих зусиль та політичної волі національних урядів за умови активного залучення громадськості.
The Little Messiah: Jesus as τῇ ἡλικίᾳ μικρός in Luke 19:3
Authors: Soon Isaac T. 
Published: March 2023

Abstract
New Testament scholars almost universally understand Zacchaeus to be “short in stature” (τῇ ἡλικίᾳ μικρὸς ἦν) in Luke 19:3. I argue that it is just as plausible, if not more so, to understand Jesus as “the short one” instead. I problematize three approaches scholars use to justify Zacchaeus as “the short one” in Luke 19: (a) that the canonical gospels do not contain physical descriptions of Jesus, unlike other ancient bioi; (b) that the syntactical and intratextual evidence in Luke 19 points incontrovertibly to Zacchaeus as the short one; and (c) that ancient physiognomic parallels related to Zacchaeus’s behavior confirm that he is the one described in Luke 19:3. I contend that readers cognizant of Luke’s portrayal of Jesus as an Aesopic fabulist or as a Socratic figure would have perceived Jesus as the one who was short. Early Christian reception of Jesus’s physical appearance, especially mediated through Origen’s report of Celsus, indicate that regarding Jesus as “the short one” in Luke 19 is plausible even in an ancient Christian context.
Introduction pages, NBHA-CN 51(1), 2023
Authors: SESTRAS Radu E. 
Published: March 2023

The papers published in Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Issue 1, Volume 51, 2023 represent new exciting research in different topics of life science, respectively in plant science, horticulture, agronomy, and crop science. Among the interesting articles we invite you to find news about: Climate change, its impact on crop production, challenges, and possible solutions; The use of phytotherapy in hepatocellular carcinoma – a systematic review; Anticancer effects of Rhinacanthus nasutus and Acanthus ebracteatus extracts against human cervical cancer cells; Iodine application in Vitis vinifera L. cv. ‘Cabernet Sauvignon’ improve bioactive compounds and enzymatic activity in berries; Arbuscular mycorrhizal fungi promote photosynthesis in Antirrhinum majus L. under low-temperature and weak-light conditions; Biocontrol of the root-knot nematode Meloidogyne incognita with Purporeocillum lilacinum and liquid bio-formulates in tomato (Solanum lycopersicum); Impacts of heat shock on productivity and quality of Triticum aestivum L. at different growth stages.
Planos de benefício definido e contribuição variável
Authors: Teixeira Rudolph , Rodrigues Adriano , Alvaro Macedo Marcelo 
Published: March 2023

Resumo
Objetivo: Verificar se os planos de benefício definido (BD) e contribuição variável (CV), das Entidades Fechadas de Previdência Complementar (EFPC) brasileiras, tendem a apresentar um volume de solvência igual ou acima do padrão de equilíbrio, quando estão próximos de atingi-lo.
Peran Guru Pendidikan Agama Islam Dalam Menanamkan Pendidikan Multikultural Berbasis Nilai-Nilai Kearifan Lokal
Authors: Supriyanto  , Amrin  
Published: March 2023

This study aims to determine the role of Islamic Religious Education teachers in instilling multicultural education based on local wisdom values ​​in Indonesia State Junior High School 15 Surakarta. Method The research used is a descriptive qualitative method with data sources obtained from the principal, teachers, and students. The data analysis used is data collection, data reduction, data presentation, and concluding. Data collection techniques are observation, interviews, and documentation as for the analysis technique through the reduction stage, data presentation stage, and stage conclusion. The results of the study indicate that the role of Islamic Religious Education teachers in instilling multicultural education based on local wisdom values ​​in Indonesia State Junior High School 15 Surakarta is teachers as educators, motivators, facilitators, with multicultural education based on local wisdom in the form of values ​​of equality, tolerance, democracy, pluralism and human values ​​(morals). Planting multicultural education based on local wisdom values is also influenced by supporting factors, namely first, support from all parties, and secondly, the school facilities are adequate. While the inhibiting factor namely the lack of good cooperation between the school and parents and guardians in shaping the character and personality of noble character in children or students.
Pengaruh Kemampuan Teknologi Digital Terhadap Prestasi Siswa SMA di JABODETABEK
Authors: Wardaya Anton , Budi Kurniawan Novianto , Hadumaon Siagian Tiodora 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kemampuan teknologi digital terhadap prestasi siswa SMA di jabodetabek. Penelitian ini menggunakan jenis penelitian kuantitatif. Populasi dalam penelitian ini yaitu siswa SMA di jabodetabek. Teknik pengambilan sampel dilakukan dengan teknik non probability sampling jenis sampling incidental. Selanjutnya dilakukan perhitungan menggunakan Rumus Slovin sehingga diperoleh sampel sebanyak 200 siswa. Teknik pengumpulan data yang digunakan yaitu kuesioner, dokumentasi dan wawancara. Data penelitian selanjutnya dianalisis menggunakan analisis regresi linear sederhana dengan bantuan SPSS 16.0. Hasil analisis data diperoleh bahwa nilai sig sebesar 0,00, maka tolak Ho sehingga dapat disimpulkan bahwa terdapat pengaruh kemampuan teknologi digital terhadap prestasi siswa. Besar pengaruh kemampuan teknologi terhadap prestasi siswa yaitu 51,80% dan sisanya 48,20% dipengaruhi oleh variabel lain.
Pengelolaan Kewirausahaan Sekolah Bagi Kepala Sekolah Dasar Negeri
Authors: Rosyidi Unifah , Karnati Neti , Rugaiyah Rugaiyah 
Published: March 2023

Administrasi sekolah dasar merupakan kegiatan penunjang keberhasilan mutu pendidikan di sekolah dasar. Ruang lingkup kegiatan administrasi sekolah diantaranya adalah pengelolaan surat dinas dan arsip sekolah. Pengelolaan surat dinas dan arsip di sekolah dasar dilakukan oleh kepala sekolah dibantu oleh seorang tenaga operator sekolah. Kemampuan mereka dalam mengelola surat dinas dan arsip sekolah masih sangat kurang. Upaya peningkatan kemampuan para Kepala Sekolah dan tenaga administrasi sekolah dasar dapat diberikan pelatihan tentang pengelolaan surat dinas dan arsip sekolah. Objek (khalayak sasaran) kegiatan pelatihan sebanyak 25 Kepala SDN di kecamatan Pulo Gadung. Mitra yang terlibat adalah Suku Dinas Pendidikan Wilayah I Kota Administrasi Jakarta Timur. Pelatihan sudah dilaksanaka selama sehari pada hari Senin, 15 Agustus 2022 melalui virtual dengan zoom cloud metting. Materi pelatihan terdiri dari: kewirausahaan dan Pendidikan kewirausahaandi sekolah; peran kepala sekolah dalam kewirausahaan; dan pengelolaan kewirausahaan sekolah dasar. Ketiga materi disampaikan oleh 3 orang dosen prodi Manajemen Pendidian FIP UNJ dengan metode ceramah, tanya jawab dan tugas. Hasil pelatihan sangat memuaskan peserta dan panitia pelaksana, karena semua materi telah disampaikan dengan baik dan sangat bermanfaat bagi semua peserta pelatihan.
Decompositional processes of microbial carbonates in Lagoa Vermelha, Brazil
Authors: Shiraishi Fumito , Hanzawa Yusaku , Asada Jiro , Cury Leonardo Fadel , Bahniuk Anelize Manuela 
Published: March 2023

ABSTRACTIn Lagoa Vermelha, Brazil, a lagoonal stromatolite and a saltpan microbial mat are investigated to understand the influence of environmental changes on the decomposition of microbial carbonates. The lagoonal stromatolite, composed mainly of magnesian calcite and aragonite, is developed on a dolomite-containing carbonate crust. While most stromatolites are eroded to the water surface level, some smaller, green stromatolites below the water surface retain a domal shape. The domal stromatolite surface is dominated by endolithic cyanobacteria with conspicuous microborings. In addition, microbial aerobic respiration causes carbonate dissolution in darkness, and metazoans grazing the inner surface of the stromatolite excrete fecal pellets. This suggests that the formational stage of lagoonal stromatolites has ceased and they are now decomposing, most likely because of environmental changes in recent years. The microbial mat, which is about 3 cm thick, developed in a saltpan pond precipitating carbonate and gypsum, and it contains quartz, magnesian calcite, aragonite, and gypsum. At the time of the investigation, the population of oxygenic phototrophs is low at the mat surface, and carbonate dissolution, rather than precipitation, is occurring by microbial metabolism deeper in the mat. This suggests that the formation of carbonate in the mat has ceased and is decomposing, probably due to the progressive salinity increase in the salt pan. This examination of two carbonate deposits in Lagoa Vermelha suggests that microbial metabolism is an important process for decomposing microbial carbonates in addition to grazing and microboring, and that environmental changes may alter microbial compositions from carbonate-constructive to carbonate-destructive communities.