bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process Mapping to inform implementation of Trauma-Informed Care for youth aged 14-24 with HIV in the Southern United States
Authors: Brown Leslie Lauren , Wilkins Megan Leigh , Pichon Latrice Crystal , Stewart Jamie Lynn , Sales Jessica McDermott , Audet Carolyn Marie , Hill Samantha Veronica , Pettit April Christine 
Published: August 2023

Abstract
Background: Trauma-Informed Care (TIC) is an evidence-based approach for improving health outcomes by providing systematic, trauma- sensitive and -responsive care. Because TIC adoption varies by setting and population, Implementation Science (IS) is particularly well-suited to guide roll-out efforts. Process Mapping (PM) is an IS model for creating shared visual depictions of systems as they are to identify rate-limiting steps of intervention adoption, but guidance on how to apply PM to guide TIC adoption is lacking. Authors of this study aimed to develop a novel method for conducting TIC-focused PM.
Methods: A real-life TIC implementation study is presented to show how TIC-focused PM was conducted in the case example of a pediatric HIV clinic in a Southern urban area with a high burden of psychological trauma among youth with HIV. A five-phase PM model was applied to evince clinic standards of care, including Preparation, planning and process identification; Data and information gathering; Map generation; Analysis; and Taking it forward. Practices and conditions from four TIC domains were assessed, including Trauma responsive services; Practices of inclusivity, safety, and wellness; Training and sustaining trauma responsiveness; and Cultural responsiveness.
Results: The TIC-focused PM method indicated the case clinic provided limited and non-systematic patient trauma screening, assessment, and interventions; limited efforts to promote professional quality of life and elicit and integrate patient experiences and preferences for care; no ongoing efforts to train and prepare workforce for trauma- sensitive or -responsive care; and no clinic-specific efforts to promote diversity, equity, and inclusion for patients and personnel.
Conclusion: Principles and constructs of resilience-focused TIC were synthesized with a five-phase PM model to generate a baseline depiction of TIC in a pediatric HIV clinic. Results will inform the implementation of TIC in the clinic. Future champions may follow the TIC-focused PM model to guide context-tailored TIC adoption.
Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during atherosclerosis
Authors: Mazan-Mamczarz Krystyna , Tsitsipatis Dimitrios , Carr Angelica , Childs Bennett , Santos Carla Rocha Dos , Anerillas Carlos , Romero Brigette , Gregg Jordan , Michel Marc , Munk Rachel , Martindale Jennifer , Piao Yulan , Fan Jinshui , Hernandez Maria , Kedei Noemi , Wong Madeline , Fedorova Olga , Batish Mona , De Supriyo , Baker Darren , Gorospe Myriam , Herman Allison 
Published: August 2023

Abstract
Studying cardiovascular senescence is crucial for understanding disease-related changes in the cardiovascular system and their impact on health and disease. To systematically investigate the heterogeneity of senescent vascular cells in atherosclerosis, we employed the senescence reporter mouse p16tdTomato+/-, overexpressed PCSK9 and fed a high-fat diet (HFD) to induce atherosclerosis, and treated them with the senolytic drug ABT-737. Whole-aorta, single-cell RNA-sequencing (scRNA-seq) and Gene Set Enrichment Analysis (GSEA) using the SenMayo panel uncovered 10 cell clusters displaying senescent features, although not ‘classical’ senescence markers, that were reduced by treatment with ABT-737. Unbiased subclustering revealed subsets of cells increasing by HFD and reduced by ABT-737 treatment that expressed unique transcripts Spp1, Ctsb, and Tnfrsf11b mRNAs. Spatial analysis of these RNAs identified senescent cells in the cap and core of brachiocephalic arteries from atherosclerotic mice. Our results uncover a vascular-specific transcriptomic signature that may be exploited for therapeutic targeting in age-related vascular diseases.
Investigating the Impacts of Airborne Dust on Herbicide Performance on Redroot Pigweed (Amaranthus retroflexus)
Authors: Kalyani Firouzeh Sharifi , Babaei Sirwan , Zafarsohrabpour Yasin , Nosratti Iraj , Gage Karla , Sadeghpour Amir 
Published: August 2023

Abstract
Dust pollution poses environmental hazards, affecting agriculture through reduced sunlight exposure, photosynthesis, crop yields, and food security. Also, dust adversely impacts plant physiology and herbicide efficacy, but our study found it can also enhance certain herbicides. A factorial experiment was conducted in 2019 and replicated in 2020 to evaluate the interactive effects of dust and various herbicide applications, including bentazon, sulfosulfuron, tribenuron-methyl, aminopyralid + florasulam, foramsulfuron + iodosulfuron + thiencarbazone, 2,4-D + MCPA, and acetochlor on redroot pigweed (Amaranthus retroflexus L.) control efficacy. Dust decreased the total chlorophyll 9.2% content of redroot pigweed by 9.2%, while herbicide application reduced the redroot pigweed’s total chlorophyll by 67.5%. The reduction of total chlorophyll content was more pronounced when herbicides were applied in the presence of dust. Herbicides and dust reduced redroot pigweed's leaf, stem weights, and biomass. Finally, the total biomass of plants was reduced by tribenuron-methyl, aminopyralid + florasulam, sulfosulfuron, and foramsulfuron + iodosulfuron + thiencarbazone regardless of dust presence, showing the most significant effect. The study results indicate that herbicides used in the presence of dust could affect redroot pigweed growth, which signifies the presence of dust, resulting in decreased control efficacy or increased rate of herbicide resistance evolution.
Effectiveness of Yoga Training on the Health-related Physical Fitness and Balance in Children with Autism Spectrum Disorder
Authors: Rostami Samira , Fayazmilani Rana , Yarani Erfan 
Published: August 2023

Abstract
Background: Children diagnosed with Autism Spectrum Disorder (ASD) experience motor difficulties that result in reduced chances for engaging in physical activities and lower levels of fitness. The unique characteristics of yoga can play a substantial role in yielding positive outcomes in terms of physical fitness.
Aim: The present study aims to evaluate the effectiveness of yoga training on the health-related physical fitness and balance of children with ASD.
Methods: Twenty-five children with ASD (mean age 10 ± 0.8 years) were included in the study and randomly assigned to two groups: yoga and control. The yoga sessions were conducted three times per week for eight weeks.
Results: The findings indicated a significant improvement in upper body muscle strength and endurance (P < 0.01), lower body strength and endurance (P < 0.001), core strength and endurance (P < 0.001), flexibility (P < 0.01), static balance (P < 0.001), and dynamic balance (P < 0.05) following yoga training. However, yoga training did not have a significant effect on body fat and cardiorespiratory endurance.
Conclusions: Based on these findings, it is suggested that integrating yoga into the therapeutic approach for children with ASD can improve musculoskeletal fitness and balance, which may have positive effects on their overall physical health and motor development.
A 3D pickup estimation method for industrial parallel robots based on point cloud simplification and registration
Authors: Zhang Yuting , Wang Zongyan , Wang Xi , Gao Pei , Li Menglong 
Published: August 2023

Abstract

In industrial environments, cameras are strongly affected by light and viewpoints, and parallel robots based on traditional vision methods have poor sorting abilities. In two-dimensional vision, depth information cannot be estimated, and parallel robots can only pick up objects based on the fixed height. In this paper, we propose a 3D pickup estimation method for parallel robots based on point cloud simplification and registration for multi-objective pickup tasks. Firstly, a point cloud segmentation method based on the spatial domain is proposed to separate incomplete object point clouds from robot space. The 3D scanner scans the complete object point clouds to produce the object dataset. Secondly, according to the fast point feature histogram (FPFH) and the weight locally optimal projection (WLOP), a fusing the FPFH and WLOP (FF-WLOP) method is proposed to simplify the incomplete point cloud and obtain more distinctive edge features of objects. The complete point cloud in the dataset is aligned with the simplified incomplete point cloud and the coordinate information of the calculated barycenter is given to the incomplete point cloud. Then a dynamic weight singular value decomposition (D-SVD) hand-eye calibration method and a best projection point strategy are proposed to transform the barycenter coordinates of the object to the best pickup coordinates. The experiment results show that the point cloud registration error is 0.38mm, the pickup rate is 92%, and the robot positioning error is 4.67mm, which meets the basic pickup requirements.
Ten cases with ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?
Authors: Pekdiker Mete , Ketenci Sertaç 
Published: August 2023

Abstract
Purpose
Vaccines are an identified cause of autoimmune/inflammatory syndrome which is termed as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In this research, we aimed to investigate the remarkable features of patients, whom we termed as ASIA syndrome, developing rheumatoid arthritis (RA) after BNT162b2 vaccination
Methods
Patients who were asymptomatic before BNT162b2 vaccination and developed chronic arthritis into three months after vaccination enrolled to the study. Demographic, laboratory, clinical, and treatment characteristics were reviewed retrospectively.
Results
We found 10 patients developing RA following BNT162b2 vaccination. The median age was 54.5 and six was of them were female. The median time between vaccination and onset of symptoms was seven days; seven patients had acute arthritis, and four had intermittent arthritis at the onset of the disease. Only three patients had a disease onset at small joints of the hands. All patients had radiological erosive changes on hand X-rays.
Conclusion
We reported a case series of ASIA syndrome for the first time who developed RA with erosive radiological features after the BNT162b2 vaccine. Acutely onset at atypical joints, intermittent course, and rapidly destructive changes on hand radiographs, were the spectacular features of our cases than classical RA. Vaccine-induced form may be an another subtype of RA but studies with larger sample sizes are needed.
Type III NRG-1 plays a regulatory role in the regeneration process of nerves from the beginning of transplantation
Authors: Wang Jun-Ning , He Sai , Yang Wei-xia , Lu Yao , Li Kun , Zhang Yu-Min , Wang Ya-Kang 
Published: August 2023

Abstract
The present study investigated the effect of type III Neuregulin-1 (NRG-1) on changes in the myelin sheath and the recovery of nerve function during the regeneration process following autologous nerve transplantation. Seventy-two Sprague-Dawley rats were divided into a Blank, Model and (antisense oligonucleotide (ASON) group. The Model and ASON groups of SD rats were subjected to autologous nerve transplantation, and the Blank group only had the sciatic nerve exposed. The Model and ASON groups weregiven local injections of 2 ml PBS buffer solution and 2 ml ASON of Type III NRG-1, respectively, the NRG-1 type III was inhibited by ASON. Changes in the sciatic nerve functional index (SFI) and conduction velocities were observed at different 6 time points. Regeneration of the myelin sheath was observed using transmission electron microscopy. Type III NRG-1 protein was detected using Western blotting and immunohistochemistry, and NRG-1 mRNA was detected using PCR. The SFI of the ASON group was lower than the Model group after transplantation. The conduction velocities of the ASON group on the 14th and 21st days after autologous nerve transplantation were lower than the Model group (P<0.01). The protein and mRNA expression of type III NRG-1 in the ASON group was lower than the Model group at all 6 time points. The area of medullated nerve fibres was significantly different between the ASON group and the Model group on the 3rd day (P<0.05), as was the number of medullated nerve fibres per unit area (P<0.01). The diameter of axons was obviously differentbetween the two groups (P<0.01). Type III NRG-1 played an important regulatory role in the regeneration process of the nerve from the beginning of transplantation to the 28th day.
Assessment of (ORIF PLUS) protocol for management of ankle fractures in diabetic patients
Authors: Abdallah Shreef 
Published: August 2023

Abstract
Back ground; treatment of ankle fractures in diabetic patients is associated with high rate of complications. ORIF plus technique is one of best protocols for management of unstable ankle fractures in diabetic patients, to date no studies to assess this method of management as regard functional outcome and rate of complications.
Methods; prospective study for patients with traumatic acute ankle fractures who will be managed with ORIF plus teqnique patients will be followed for at least six month post-operative for assessment of functional outcome and rate of complications including; infection, nonunion , reoperation ,salvage arthrodesis or amputation .
Results; the obtained results will be collected summarized and statically and analyzed.
Conclusion; this will includes recommendations according to final results.
Patient–physician communication during oncological follow-up visits in a Chinese outpatient clinic
Authors: Zhan Yinxia , Mao Peiyang , Gao Feng , Xu Wei , Pu Yang , Feng Gang , Wang Jin , Liao Dongbiao , Zhao Zhenhua , Zhang Yu , Li Jie , Shi Qiuling , Du Xiaobo 
Published: August 2023

Abstract
Background
As the number of cancer survivors rises, patient care focus has recently shifted towards outpatient services, emphasizing the management of chronic conditions. As health systems struggled to meet the increasing demands, a greater emphasis has been placed on improving the efficiency of outpatient visits. However, given the restricted visitation duration in China’s crowed outpatient clinics, it remains uncertain whether symptoms induced by cancer or its treatment receive adequate treatment.
Objective
We aimed to analyze the duration of routine follow-up visits for patients with cancer and the nature of their communication with doctors during these visits. Improving oncological outpatient services and reducing work pressure on oncologists, by identifying the core needs of cancer patients and determining the time required for physicians to address these needs.
Method
From Oct-Nov 2022, patients in the oncology outpatient clinic at a tertiary A hospital in China were recruited. Demographic and disease characteristics of patients were collected in the outpatient clinic, and fixed-effects models were used to analyze factors affecting the visit length.
Results
Total 488 established patients and 28 newly diagnosed patients were involved. The median duration taken by physicians to attend to the new and established groups was 7 minutes (4–11 minutes) and 4 minutes (3–7 minutes), respectively. Among the established patients, those for regular outpatient follow up (79.71%) spent 4 minutes (3–6 minutes) with their doctors, those for therapy counseling (10.86%) spent 6 minutes (4–9 minutes), those for insurance reimbursement (4.92%) spent 5 minutes (4–7.5 minutes), those for symptoms distress (4.51%) spent 6.5 minutes (4–9 minutes). The following attributes had significant impact on the visit time: the composition of visitors (OR = 0.57 [95% CI, 0.23–0.91]), patient education level (OR = 0.75 [95% CI, 0.03–1.47]), whether the patient was currently receiving anti-cancer treatment (OR = 0.79 [95% CI, 0.18–1.40]), and different core complaints for the appointment (OR = 0.55 [95% CI, 0.19–0.91]).
Conclusion
Our work describes the status of the content and duration of doctor–patient communication in oncological follow-up clinics in public hospitals in China. Patients had a single need for clinic visits, especially those attending a follow-up after discharge. Physicians spent as much time dealing with reimbursement issues as they spent on routine follow-up visits. Complaints of symptom distress were rare, and the reason for this needs to be investigated further. While oncology outpatient physicians in China have a heavy workload, patients' needs should be given sufficient attention.
Arrowroot (Maranta arundinacea): Variation in Morphological and Yield Traits across Sri Lanka's Agro-climatic Zones and Genetic Diversity Assessment
Authors: Malki Susanga , Sivashoby S , Ratnayake Kamani , wijesinghe Amani , Gimhani Radhika 
Published: August 2023

Abstract

Arrowroot (Maranta arundinacea) is an underutilized tuber crop in Sri Lanka. This study evaluated thirteen quantitative and four qualitative plant morphological traits across the arrowroot populations in Sri Lanka's seven agro-climatic zones. Principal component analysis was done to identify the lead plant morphological traits for arrowroot plant and cluster analysis was performed to evaluate the similarity level among collected plant populations. Twenty M. arundinacea genotypes from different agro ecological regions of Sri Lanka were screened for genetic diversity using ISSR markers. Nine of the thirteen quantitative morphological traits were found to be significantly distinct from one another. Seven out of thirteen quantitative plant morphological traits were identified as lead plant morphological traits for production of quality rhizomes for crop selection, improvement, and application in Sri Lanka. Five ISSR markers produced 53 bands in total across 20 samples, with an average frequency of 10.6 bands per primer. The ISSR-PCR analysis revealed a high level of polymorphism (94.34%). Primer UBC 811 has the highest PIC value (0.428), indicating that it is the most informative marker for assessing genetic diversity in M. arundinacea. The genotypes from the wet zone and dry zone were categorized individually based on the dendrogram created using UPGMA cluster analysis. The study found genetic variety in M. arundinacea based on their varied agro ecological zones, and the current findings will be useful in future crop improvement efforts in M. arundinacea.
Do nurses’ career competencies act as mediators and predictors between job resources and work engagement in the job demands-resources theory? A cross-sectional study
Authors: Yamada Masako , Asakura Kyoko , Takada Nozomu , Sugiyama Shoko 
Published: August 2023

Abstract
Background: Since nurses have various career options, it is essential for them to possess career competencies which are the knowledge, skills, and abilities for their career self-management. Nurses’ roles have expanded globally due to dynamically changing healthcare settings and advanced specialization fields. In this context, career competencies may help nurses to navigate their careers successfully. However, few studies have investigated the association between career competencies and positive work-related outcomes for nurses. Our study aimed to examine whether nurses’ career competencies act as mediators and predictors between job resources and work engagement in the motivational processes of the job demand-resources theory. We explored whether career competencies and four types of job resources (supervisor support, coworker support, role clarity, and career opportunities) are mutually related and lead to work engagement.
Methods: A cross-sectional survey was conducted between July and August 2022. Mediation analyses were conducted using structural equation modeling with data from 263 nurses working in hospitals in the Tohoku region of Japan.
Results: Career competencies mediated the relationship between the four types of job resources and work engagement. Furthermore, career competencies enhanced work engagement through increased supervisor support and career opportunities.
Conclusions: Our results indicate that career competencies are a critical personal resource for enhancing work engagement in the motivational process of the job demand-resources theory. We trust that our insights will contribute to effective nursing management and continuing education.
EDB-mediated neuroprotection against acute ischemic brain injury is associated with reduced central and peripheral inflammation
Authors: Wang Dongxue , Wang Yutao , Jiang Wenyi , Shi Junfeng , Huang Wenting , Cao Chengkun , Wang Xue , Zhang Gongchun , Li Yuankuan , Chen Keyang , Lee Kwang-Youl , Lin Li 
Published: August 2023

Abstract
Post-stroke inflammation is instrumental in the cascade of secondary injury, and it is orchestrated by resident microglia, astrocytes, and circulating immune cells. Controlling the destructive inflammatory response is a promising avenue for stroke therapy. Edaravone dexborneol (EDB) has been identified as a clinical protectant for stroke management. However, the impact of systemic EDB administration on the central and peripheral inflammation following stroke has not been fully characterized. In this study, we investigate the immunomodulatory effects of EDB on the central and peripheral immune systems in a mouse model of experimental stroke. Our results indicate that EDB administration significantly ameliorated MCAO-induced infarction and neurological deficits by regulating the production of inflammatory cytokines and chemokines. Specifically, EDB restrained the polarization of M1 microglia and A1-type astrocytes, as well as the expression of TNF-α, IL-1β, and IL-6. Furthermore, EDB upregulated tight junction expression and attenuated the accumulation of peripheral leukocytes in the ischemic brain. Additionally, systemic EDB administration inhibited the expression of M1 macrophages and the macrophage-dependent inflammatory response in the spleen and blood. These data indicate that EDB plays a neuroprotective role in acute ischemic brain injury by regulating the central and peripheral inflammation mediated by brain-resident microglia, astrocytes, and circulating leukocytes.