bluuebunny/crossref_metadata_2025_split huggingface dataset:
A deep learning-based method for predicting the low-cycle fatigue life of austenitic stainless steel
Authors: Duan Hongyan , Yue Shunqiang , Liu Yang , He Hong , Zhang Zengwang , Zhao Yingjian 
Published: August 2023

Abstract
In modern engineering, predicting the fatigue life of materials is crucial for safety assessment. The relationship between fatigue life and its influencing factors is difficult to predict by traditional methods, and deep learning can achieve great power and flexibility through nested hierarchies of concepts. Taking the low cycle fatigue life of 316 austenitic stainless steel as an example, a method for predicting the low cycle fatigue life of austenitic stainless steel by deep learning is established based on the limited ability of traditional neural network model and genetic algorithm optimization model. The deep neural network model is introduced to predict the fatigue life of the material. The results show that the prediction correlation coefficient R of the deep neural network prediction model with three hidden layers is 0.991, and the deep neural network learning model has better prediction ability.
Structural properties of graded In
x
Ga 1−x
As metamorphic buffer layers for quantum dots emitting in the telecom bands
Authors: Scaparra Bianca , Ajay Akhil , Avdienko Pavel S , Xue Yuyang , Riedl Hubert , Kohl Paul , Jonas Björn , Costa Beatrice , Sirotti Elise , Schmiedeke Paul , Villafañe Viviana , Sharp Ian D , Zallo Eugenio , Koblmüller Gregor , Finley Jonathan J , Müller Kai 
Published: August 2023

Abstract
In recent years, there has been a significant increase in interest in tuning the emission wavelength of InAs quantum dots (QDs) to wavelengths compatible with the already existing silica fiber networks. In this work, we develop and explore compositionally graded In
x
Ga

1
−
x

As metamorphic buffer layers (MBLs), with lattice constant carefully tailored to tune the emission wavelengths of InAs QDs towards the telecom O-band. The designed heterostructure is grown by molecular beam epitaxy (MBE), where a single layer of InAs QDs is grown on top of the MBL and is capped with a layer having a fixed indium (In) content. We investigate the structural properties of the grown MBLs by reciprocal space mapping, as well as transmission electron microscopy, and verify the dependence of the absorption edge of the MBL on the In-content by photothermal deflection spectroscopy measurements. This allows us to identify a growth temperature range for which the MBLs achieve a near-equilibrium strain relaxation for In-content up to ∼30

%

. Furthermore, we explore the emission wavelength tunability of QDs grown on top of a residual strained layer with a low density of dislocations. Specifically, we demonstrate a characteristic red-shift of the QD photoluminescence towards the telecom O-band (1300 nm) at low temperature. This study provides insights into the relaxation profiles and dislocation propagation in compositionally graded MBLs grown via MBE thus paving the way for realizing MBE-grown heterostructures containing InAs QDs for advanced nanophotonic devices emitting in the telecom bands.
Novel “Z” Technique to Overcome Warping of Costal Cartilage
Authors: Zhang Zhe , Wu Junzheng , Yu Zhou , Zhang Yu , Zhang Juan , Song Baoqiang 
Published: August 2023

Abstract

Background
Dorsal augmentation with costal cartilage is generally used for aesthetic rhinoplasty. However, the tendency of costal cartilage to warp may jeopardize the aesthetic outcome.

Objectives
The aim of this study was to describe a new “Z” technique to overcome the warping of costal cartilage after implantation and to evaluate the efficacy of this technique in vitro.

Methods
A total of 31 pairs of porcine costal cartilage grafts (40 mm × 10 mm × 5 mm) were obtained and kept in Dulbecco's Modified Eagle Medium (Sigma-Aldrich, St. Louis, MO) to maintain cell viability. Paired grafts were obtained and randomly allocated for preparation by the accordion technique and the “Z” technique. Standardized photographs (obtained immediately after operation and at 4 weeks) were used for warping analysis. Biomechanical testing was performed to measure the graft's capacity to resist deformation by an external force.

Results
Cell viability of the grafts at 4 weeks was comparably good in the accordion group and the Z group (61.88% ± 4.47% vs 67.48% ± 7.03%, P = 0.55). Warping angle was comparable between the 2 groups (P &gt; 0.01). The capacity to resist external force was significantly better in the Z group; the force needed to cause deformation was 3.98 ± 1.04 N in the Z group vs 1.61 ± 0.47 N in the accordion group in lateral view (P &lt; 0.0001), and 1.33 ± 0.41 N vs 0.96 ± 0.24 N, respectively, in frontal view (P = 0.0013).

Conclusions
The “Z” technique appears to be a simple and effective method to minimize the tendency of costal cartilage to warp after implantation.
‘4-Check’ protocol for intraoperative anastomotic assessment during transanal total mesorectal excision: retrospective cohort study
Authors: Tirelli Flavio , Lorenzon Laura , Biondi Alberto , Neri Ilaria , Santoro Gloria , Persiani Roberto 
Published: August 2023

Abstract

Background
Anastomotic leakage is a major complication following rectal cancer surgery. The primary aim of this study was to investigate the efficacy of a protocol based on a quadruple intraoperative anastomotic assessment (4-Check) during transanal total mesorectal excision (TaTME).

Methods
Patients who underwent TaTME for rectal cancer with primary anastomosis were reviewed and divided into two groups: before (pre-4-Check: April 2015 - April 2019) and after the implementation of the 4-Check protocol (May 2019 - May 2022). This protocol consisted of a multimodal anastomotic integrity assessment, including indocyanine green-evaluation of colonic stump and intraluminal anastomosis perfusion, a reverse air leak test and anastomotic doughnuts assessment. The primary outcome was incidence of clinical and/or radiological anastomotic leakage. The secondary outcome included intraoperative anastomosis defects and repairs and 30-day complication rate. Propensity score matching and multivariable analyses were performed.

Results
Of 186 patients, 160 were selected: 86 patients in the pre-4-Check and 74 in the 4-Check group. After propensity score matching, there was no difference in postoperative anastomotic leakage (pre-4-Check versus 4-Check: 11.1 per cent versus 7.4 per cent; P = 0.50). However, in the 4-Check group, the intraoperative detection of defects and repairs was significantly increased (P = 0.03), and the number of complications was reduced (pre-4-Check versus 4-Check: 33.3 per cent versus 9.3 per cent, P = 0.004). Multivariable analyses confirmed that the use of the 4-Check protocol, the detection of anastomotic defects and increased albumin levels were associated with a reduced number of complications.

Conclusion
The 4-Check protocol allowed the intraoperative detection and repair of anastomotic defects. Anastomotic leakage rates were not reduced; however, 30-day complication rates were lower after implementation of this protocol.
Prevalence of Comorbid Factors in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Randomized Trial of an Oral Microbiota–Based Therapeutic
Authors: Berenson Charles S , Lashner Bret , Korman Louis Y , Hohmann Elizabeth , Deshpande Abhishek , Louie Thomas J , Sims Matthew , Pardi Darrell , Kraft Colleen S , Wang Elaine E L , Cohen Stuart H , Feuerstadt Paul , Oneto Caterina , Misra Bharat , Pullman John , De Ananya , Memisoglu Asli , Lombardi David A , Hasson Brooke R , McGovern Barbara H , von Moltke Lisa , Lee Christine H 
Published: August 2023

Abstract

Background
Although comorbidities are risk factors for recurrent Clostridioides difficile infection (rCDI), many clinical trials exclude patients with medical conditions such as malignancy or immunosuppression. In a phase 3, double-blind, placebo-controlled, randomized trial (ECOSPOR III), fecal microbiota spores, live (VOWST, Seres Therapeutics; hereafter “VOS,” formerly SER-109), an oral microbiota therapeutic, significantly reduced the risk of rCDI at week 8. We evaluated the efficacy of VOS compared with placebo in patients with comorbidities and other risk factors for rCDI.

Methods
Adults with rCDI were randomized to receive VOS or placebo (4 capsules daily for 3 days) following standard-of-care antibiotics. In this post hoc analysis, the rate of rCDI through week 8 was assessed in VOS-treated participants compared with placebo for subgroups including (i) Charlson comorbidity index (CCI) score category (0, 1–2, 3–4, ≥5); (ii) baseline creatinine clearance (&lt;30, 30–50, &gt;50 to 80, or &gt;80 mL/minute); (iii) number of CDI episodes, inclusive of the qualifying episode (3 and ≥4); (iv) exposure to non-CDI-targeted antibiotics after dosing; and (v) acid-suppressing medication use at baseline.

Results
Of 281 participants screened, 182 were randomized (59.9% female; mean age, 65.5 years). Comorbidities were common with a mean overall baseline age-adjusted CCI score of 4.1 (4.1 in the VOS arm and 4.2 in the placebo arm). Across all subgroups analyzed, VOS-treated participants had a lower relative risk of recurrence compared with placebo.

Conclusions
In this post hoc analysis, VOS reduced the risk of rCDI compared with placebo, regardless of baseline characteristics, concomitant medications, or comorbidities.
Powassan Virus Encephalitis: A Tertiary Center Experience
Authors: Mendoza Maria Alejandra , Hass Reece M , Vaillant James , Johnson Derek R , Theel Elitza S , Toledano Michel , Abu Saleh Omar 
Published: August 2023

Abstract

Background
Powassan virus (POWV) is an emerging arthropod-borne flavivirus, transmitted by Ixodes spp. ticks, which has been associated with neuroinvasive disease and poor outcomes.

Methods
A retrospective study was conducted at Mayo Clinic from 2013 to 2022. We included clinical and epidemiologic data of probable and confirmed neuroinvasive POWV cases.

Results
Sixteen patients with neuroinvasive POWV were identified; their median age was 63.2 years, and 62.5% were male. Six patients presented with rhombencephalitis, 4 with isolated meningitis, 3 with meningoencephalitis, 2 with meningoencephalomyelitis, and 1 with opsoclonus myoclonus syndrome. A median time of 18 days was observed between symptom onset and diagnosis. Cerebrospinal fluid analysis showed lymphocytic pleocytosis with elevated protein and normal glucose in the majority of patients. Death occurred within 90 days in 3 patients (18.8%), and residual neurologic deficits were seen in 8 survivors (72.7%).

Conclusions
To our knowledge, this is the largest case series of patients with neuroinvasive POWV infection. We highlight the importance of a high clinical suspicion among patients who live in or travel to high-risk areas during the spring to fall months. Our data show high morbidity and mortality rates among patients with neuroinvasive disease.
Kinesiophobia and associated variables in patients with heart failure
Authors: Sentandreu-Mañó Trinidad , Deka Pallav , Almenar Luis , Tomás José M , Ferrer-Sargues Francisco-José , López-Vilella Raquel , Klompstra Leonie , Marques-Sule Elena 
Published: August 2023

Abstract

Aims
Patients with heart failure (HF) can exhibit kinesiophobia, an excessive, debilitating, and irrational fear of movement. This study aimed to enhance the understanding of kinesiophobia in patients with HF by analysing associations with the following variables: musculoskeletal pain, quality of life, quality of sleep, functional capacity, disability, frailty, sex, and age.

Methods and results
In this cross-sectional study, 107 participants were included, with ages ranging from 28 to 97 years (57% men, mean age 73.18 ± 12.68 years). Multiple regression analyses were performed with all variables, including polynomial regressions for variables with a non-linear relationship. Kinesiophobia was significantly correlated (P &lt; 0.01) with musculoskeletal pain, quality of life, quality of sleep, functional capacity, disability, and being at risk of frailty, while age and sex were not statistically significant. Frailty disability and musculoskeletal pain intensity were variables linearly associated with kinesiophobia, while quality of sleep and disability had a non-linear relationship with kinesiophobia.

Conclusion
Kinesiophobia needs to be evaluated and better understood in patients with HF to improve physical activity and exercise adherence. This study found that musculoskeletal pain intensity, quality of sleep, disability, and frailty risk have a significant association with kinesiophobia in patients with HF. Our results suggest multi-dimensional associations of kinesiophobia in patients with HF, which require further examination and understanding.
Time trends in income-related disparity in incidence of acute coronary syndrome
Authors: Simoni Amalie H , Kragholm Kriatian H , Bøggild Henrik , Jensen Svend E , Valentin Jan B , Johnsen Søren P 
Published: August 2023

Abstract

Background
Higher incidence of acute coronary syndrome (ACS), among those with lower income, has been recognized in the most recent decades. Still, there is a paucity of data on temporal changes. This study aims to investigate 20-year time trends in income-related disparity in the incidence of ACS in Denmark.

Methods
This Population-based repeated cross-sectional study included all patients with first-time ACS, aged ≥20 years, registered in the Danish National Patient Registry 1998–2017. Aggregated sociodemographic data for the Danish population was accessed from Statistics Denmark. Yearly incidence rates (IR) and incidence rate ratios (IRR), with the highest-income quartile as a reference, were standardized using cell-specific personal equivalent income according to year, sex and age group with 95% confidence intervals. Interaction analysis was executed for differences in IR of ACS between the lowest- and highest-income quartile over time.

Results
A total of 220 070 patients hospitalized with ACS from 1998 to 2017 were identified. The yearly standardized ACS IRs decreased in all income quartiles. However, the IR remained higher in the lowest-income quartile compared to the highest for both men [1998: IRR 1.45 (95% confidence interval, CI 1.39–1.52) and 2017: 1.47 (1.40–1.54)] and women [1998: IRR 1.73 (1.64–1.82) and 2017: 1.76 (1.65–1.88)]. Interaction analysis showed that over the period the difference in IR between the lower- and the highest-income quartile decreased with 1–5 ACS cases per 100 000 person-year.

Conclusion
Income-related disparity in the incidence of ACS was present in Denmark between 1998 and 2017. Despite a marked overall decrease in the yearly ACS incidence, the extent of income-related disparity remained unchanged.
Illuminating the oral microbiome: cellular microbiology
Authors: Lamont Richard J , Miller Daniel P , Bagaitkar Juhi 
Published: August 2023

Abstract
Epithelial cells line mucosal surfaces such as in the gingival crevice and provide a barrier to the ingress of colonizing microorganisms. However, epithelial cells are more than a passive barrier to microbial intrusion, and rather constitute an interactive interface with colonizing organisms which senses the composition of the microbiome and communicates this information to the underlying cells of the innate immune system. Microorganisms, for their part, have devised means to manipulate host cell signal transduction pathways to favor their colonization and survival. Study of this field, which has become known as cellular microbiology, has revealed much about epithelial cell physiology, bacterial colonization and pathogenic strategies, and innate host responses.
The 95 per cent confidence interval for the mean sea-level change rate derived from tide gauge data
Authors: Wang Guoquan 
Published: August 2023

SUMMARYTide gauge (TG) data are crucial for assessing global sea-level and climate changes, coastal subsidence and inundation. Mean sea-level (MSL) time-series derived from TG data are autocorrelated. The conventional ordinary least-squares regression method provides reasonable estimates of relative sea-level (RSL) change rates (linear trends) but underestimates their uncertainties. In order to cope with the autocorrelation issue, we propose an approach that uses an ‘effective sample size’ (${N}_{\mathrm{ eff}}$) to estimate the uncertainties (±95 per cent confidence interval, or 95 per cent CI for short). The method involves decomposing the monthly MSL time-series into three components: a linear trend, a periodic component and a noise time-series. The ${N}_{\mathrm{ eff}}$ is calculated according to the autocorrelation function (ACF) of the noise time-series. We present an empirical model that fits an inverse power-law relationship between 95 per cent CI and time span (T) based on 1160 TG data sets globally distributed, where $95\ \mathrm{ per}\ \mathrm{ cent}\,\mathrm{ CI} = 179.8{T}^{ - 1.29}$. This model provides a valuable tool for projecting the optimal observational time span needed for the desired uncertainty in sea-level rise rate or coastal subsidence rate from TG data. It suggests that a 20-yr TG time-series may result in a 3–5 mm yr−1 uncertainty (95 per cent CI) for the RSL change rate, while a 30-yr data set may achieve about 2 mm yr−1 uncertainty. To achieve a submillimetre per year (&lt; 1 mm yr−1) uncertainty, approximately 60 yr of TG observations are needed. We also present a Python module (TG_Rate_95CI.py) for implementing the methodology. The Python module and the empirical model have broad applications in global sea-level rise and climate change studies, and coastal environmental and infrastructure planning, as well as Earth science education.
Prevalence of Disease-Related Malnutrition and Micronutrients Deficit in Patients with Inflammatory Bowel Disease: A Multicentric Cross-Sectional Study by the GSMII (Inflammatory Bowel Disease Study Group)
Authors: Viganò Chiara , Palermo Andrea , Mulinacci Giacomo , Pirola Lorena , Losco Alessandra , Meucci Gianmichele , Saibeni Simone , Pastorelli Luca , Amato Arnaldo , Gatti Mario , Cortelezzi Claudio , Di Sabatino Antonio , Morganti Daniela , Boni Francesca , Grasso Gianalberto , Casella Giovanni , Casini Valentina , Caprioli Flavio Andrea , Vecchi Maurizio , Bezzio Cristina , Bergna Irene , Radaelli Franco , Mengoli Caterina , Massironi Sara 
Published: August 2023

Abstract

Background and Aims
Inflammatory bowel disease (IBD) patients might experience disease-related malnutrition (DRM), but prevalence and risk factors are not well defined. The primary aim of the study was to define the prevalence of DRM and micronutrient deficiency in IBD patients; the secondary aim was to assess variables related to DRM.

Materials and methods
A multicenter, cross-sectional study was performed including consecutive adult IBD patients during a period of 2 weeks. Nutritional status was assessed with the body mass index (BMI) and the Malnutrition Universal Screening Tool. DRM was defined according to European Society for Clinical Nutrition and Metabolism guidelines.

Results
Among the 295 enrolled patients, the prevalence of DRM was 23%, with no statistical difference between Crohn’s disease and ulcerative colitis. Compared with well-nourished patients, patients with DRM showed higher rate of hospitalization in the previous month, were more often receiving systemic steroids, and had lower hemoglobin, albumin, and prealbumin levels and higher median C-reactive protein levels. At univariate logistic regression, current hospitalization, hospitalization in the previous month, low serum albumin, low BMI, high C-reactive protein, high Crohn’s Disease Activity Index, and female sex were variables related to DRM. At the multivariate logistic regression, low BMI, current hospitalization and hospitalization in the previous month were significantly associated with DRM. In 23% of IBD patients, a deficiency of at least 1 micronutrient was observed, with no difference between ulcerative colitis and Crohn’s disease.

Conclusions
DRM and microelements malnutrition are frequent conditions in the IBD population. DRM seems to be associated with disease activity and hospitalization.
Exploring Colitis through Dynamic T Cell Adoptive Transfer Models
Authors: Yang Wenjing , Cong Yingzi 
Published: August 2023

Abstract
Numerous animal models of colitis have provided important insights into the pathogenesis of inflammatory bowel disease (IBD), contributing to a better understanding of the underlying mechanisms for IBD. As aberrant CD4+ T cell responses play a critical role in the pathogenesis and development of IBD, T cell adoptive transfer models of colitis have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation. While the adoptive transfer of CD4+ CD45RBhi T cells into immunedeficient recipient mice was the first discovered and is currently the most widely used model, several variations of the T cell transfer model have also been developed with distinct features. Here, we describe the history, principle, and characteristics of adoptive transfer colitis models and discuss their strengths, limitations, and applications.
Neuronal and Glial Metabolite Abnormalities in Participants With Persistent Neuropsychiatric Symptoms After COVID-19: A Brain Proton Magnetic Resonance Spectroscopy Study
Authors: Ernst Thomas , Ryan Meghann C , Liang Hua-Jun , Wang Justin P , Cunningham Eric , Saleh Muhammad G , Kottilil Shyamasundaran , Chang Linda 
Published: August 2023

Abstract

Background
The aim of this study was to determine whether neurometabolite abnormalities indicating neuroinflammation and neuronal injury are detectable in individuals post–coronavirus disease 2019 (COVID-19) with persistent neuropsychiatric symptoms.

Methods
All participants were studied with proton magnetic resonance spectroscopy at 3 T to assess neurometabolite concentrations (point-resolved spectroscopy, relaxation time/echo time = 3000/30 ms) in frontal white matter (FWM) and anterior cingulate cortex–gray matter (ACC-GM). Participants also completed the National Institutes of Health Toolbox cognition and motor batteries and selected modules from the Patient-Reported Outcomes Measurement Information System.

Results
Fifty-four participants were evaluated: 29 post–COVID-19 (mean ± SD age, 42.4 ± 12.3 years; approximately 8 months from COVID-19 diagnosis; 19 women) and 25 controls (age, 44.1 ± 12.3 years; 14 women). When compared with controls, the post–COVID-19 group had lower total N-acetyl compounds (tNAA; ACC-GM: −5.0%, P = .015; FWM: –4.4%, P = .13), FWM glutamate + glutamine (–9.5%, P = .001), and ACC-GM myo-inositol (−6.2%, P = .024). Additionally, only hospitalized patients post–COVID-19 showed age-related increases in myo-inositol, choline compounds, and total creatine (interaction P = .029 to &lt;.001). Across all participants, lower FWM tNAA and higher ACC-GM myo-inositol predicted poorer performance on several cognitive measures (P = .001–.009), while lower ACC-GM tNAA predicted lower endurance on the 2-minute walk (P = .005).

Conclusions
In participants post–COVID-19 with persistent neuropsychiatric symptoms, the lower-than-normal tNAA and glutamate + glutamine indicate neuronal injury, while the lower-than-normal myo-inositol reflects glial dysfunction, possibly related to mitochondrial dysfunction and oxidative stress in Post-COVID participants with persistent neuropsychiatric symptoms.