bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sure they Gamble – But At Least They’re Not Being Bullied! A Survey of Parental Perspectives of Adolescent Gambling
Authors: Dittman Cassandra K. , Gossner Michelle , Browne Matthew , Hing Nerilee , Rockloff Matthew , Russell Alex M. T. , Lole Lisa 
Published: January 2025

Abstract
There is almost no research on adolescent gambling from the perspective of parents, despite their important role in preventing adolescent engagement in potentially risky and harmful activities. This study used a quantitative online survey of 1,185 parents (69% mothers) of adolescents (aged 12 to 17 years) to examine parental attitudes and knowledge of adolescent gambling and adolescent exposure to parental gambling. Most parents disapproved of adolescents being exposed to gambling and that gambling was less concerning than other adolescent issues (e.g., bullying, drugs). Despite being concerned by gambling, parents reported that adolescent gambling was common and often gambled in the presence of their adolescent; particularly fathers. Fathers were also more likely to hold positive attitudes towards adolescent gambling, and reported higher levels of adolescent gambling and simulated gambling. These findings suggest that public health strategies to prevent adolescent gambling should build parental awareness of gambling and its risks and harms.
The role of beta band phase resetting in audio-visual temporal order judgment
Authors: Li Yueying , Noguchi Yasuki 
Published: January 2025

Abstract
The integration of auditory and visual stimuli is essential for effective language processing and social perception. The present study aimed to elucidate the mechanisms underlying audio-visual (A-V) integration by investigating the temporal dynamics of multisensory regions in the human brain. Specifically, we evaluated inter-trial coherence (ITC), a neural index indicative of phase resetting, through scalp electroencephalography (EEG) while participants performed a temporal-order judgment task that involved auditory (beep, A) and visual (flash, V) stimuli. The results indicated that ITC phase resetting was greater for bimodal (A + V) stimuli compared to unimodal (A or V) stimuli in the posterior temporal region, which resembled the responses of A-V multisensory neurons reported in animal studies. Furthermore, the ITC got lager as the stimulus-onset asynchrony (SOA) between beep and flash approached 0 ms. This enhancement in ITC was most clearly seen in the beta band (13–30 Hz). Overall, these findings highlight the importance of beta rhythm activity in the posterior temporal cortex for the detection of synchronous audiovisual stimuli, as assessed through temporal order judgment tasks.
Patient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group
Authors: Javier R. M. , Debiais F. , Alliot-Launois F. , Poivret D. , Bosgiraud P. , Barbe F. , Bouyssié M. , Devert M. , Roux F. , Sacchi M. P. , Sirot S. , Halbout P. , Chevalley T. , Reginster J. Y. , Cortet B. 
Published: January 2025

Abstract

Summary
The management of osteoporosis even after a fracture is declining. Our pilot study in patients with osteoporosis confirms a large ignorance of the disease and major fears and uncertainties about the treatments. Complete and sustained medical information seems essential to counteract the contradictory information, which are exclusively negative.

Purpose
The management of osteoporosis (OP) even after a fracture has declined over recent years despite the actions of the medical societies concerned with this disease. The objective of this pilot study was to investigate patients’ perceptions of OP, their treatment pathways, and how information is obtained.

Methods
The Association Française de Lutte Anti-Rhumatismale (AFLAR) constituted an advisory group of 7 French patients (mean age 63.7 years [54–74 years]), with various stages of OP and duration of disease. A qualitative, anonymized study was conducted with an open-ended semi-structured questionnaire, with a contribution of the International Osteoporosis Foundation (IOF) and the “Groupe de Recherche et Informations sur les Ostéoporoses” (GRIO).

Results
The onset of OP was often sudden, with the fracture occurring in a context of deep misunderstanding of OP by both the public and physicians. The patients have confidence in the physician, mostly a rheumatologist, who informs about OP and initiates the treatment. The main cause of non-adherence being major fears and uncertainties about efficacy and safety of treatments. Medical information is considered as insufficient, or poorly understood. Negative information has the highest impact, even if the sources seem unreliable, such as media. There is no trust in pharmaceutical companies and the ethics of physicians are in question.

Conclusion
This IOF/GRIO/AFLAR Patient Advisory Group pilot study illustrates the numerous barriers to effective OP management. Complete and sustained medical information, especially at the time of diagnosis and initiation of treatment, seems essential to counteract the contradictory information, which are exclusively negative.
How do boundary objects influence people-centered smart cities? A systematic literature review
Authors: Esposito Gabriella , Bertello Alberto , Mora Luca , Tucek David 
Published: January 2025

Abstract
This study explores the critical role of boundary objects in the context of people-centred smart cities, a new paradigm in urban development that emphasises citizen participation in planning and decision-making. Boundary objects—artefacts, documents, or concepts that facilitate communication and collaboration across different knowledge domains—are increasingly recognized as essential tools in the complex, multi-stakeholder environment of urban governance. Despite extensive research on boundary objects in organizational contexts, their specific application in smart cities remains underexplored. This study addresses this gap by investigating how BOs, particularly collaborative tools and spaces, contribute to innovation, engagement, and knowledge-sharing in people-centred smart cities. Employing a Systematic Literature Review following the PRISMA protocol, this research synthesizes key insights from scholarly articles to comprehensively understand boundary objects' role in urban governance. This study offers a theoretical framework for leveraging boundary objects to enhance the inclusivity and sustainability of smart cities. It suggests avenues for future research, including empirical validation and exploration of boundary objects in diverse geographic and cultural contexts.
Sodium-Directed Crosstalk Between Immune Cells and Lymphatic Vessels
Authors: Ahmad Taseer , Crescenzi Rachelle , Kon Valentina , Kirabo Annet , Shelton Elaine L. 
Published: January 2025

Abstract

Purpose of Review
The role of the lymphatic system in clearing extravasated fluids, lipid transport, and immune surveillance is well established, and lymphatic vasculature can provide a vital role in facilitating crosstalk among various organ systems. Lymphatic vessels rely on intrinsic and local factors to absorb and propel lymph from the interstitium back to the systemic circulation. The biological implications of local influences on lymphatic vessels are underscored by the exquisite sensitivity of these vessels to environmental stimuli. This review is intended to highlight the role of sodium within the local environment in mediating lymphatic and immune cell interactions that contribute to changes in function and disease progression.

Recent Findings
We discuss evidence that accumulation of interstitial sodium modulates lymphatic growth, pumping dynamics, and permeability of renal lymphatics, which involves activation of sodium potassium chloride co-transporter (NKCC1) in lymphatic endothelial cells. These recent findings complement observations that sodium activates immune cells via the epithelial sodium channel (ENaC), leading to the formation and accumulation of lipid oxidation products, isolevuglandins (IsoLGs), in antigen presenting cells, which in turn promotes T cell activation and vasculopathy. In addition, we will underscore the physiologic relevance of altered interplay between immune cells and lymphatics in the sodium avid state that characterizes kidney diseases and consider how sodium accumulation in the interstitial compartment of the kidney modulates the lymphatic network and the interactions between renal lymphatics and activated immune cells.

Summary
Finally, this article calls attention to persisting knowledge gaps and stresses the need for additional studies to identify salt-sensing mechanisms, including sodium-activated immune cells and lymphatic endothelial cell interactions, for targeted therapeutic interventions in the setting of renal disease.
Smart Mechanical Structures and Design for Advanced Adhesives: A Review
Authors: Kim Jaeil , Choi Geonjun , Park Seongjin , Kim Minwook , Kim Kwangjun , Jung Ho-Sup , Kwak Moon Kyu , Ok Jong G. , Jeong Hoon Eui 
Published: January 2025

Abstract
Smart adhesives with engineered mechanical structures have emerged as a transformative technology with broad applications in fields such as wearable healthcare devices, bioengineering, and soft robotics. By integrating advanced mechanical architectures like kirigami, tessellations, and multilayered designs, these adhesives exhibit enhanced surface and mechanical properties that lead to superior interfacial adhesion. Such designs offer critical advantages—improved stretchability, substrate conformability, and increased adhesion strength—over conventional adhesives. This review explores the range of engineered structures used in smart adhesives and demonstrates how these innovations address the limitations of traditional adhesives. Additionally, we discuss their applications in wearable healthcare devices, flexible electronics, and robotics.
Nisin A Treatment to Protect Honey Bee Larvae from European Foulbrood Disease
Authors: Nakamura Keiko , Takamatsu Daisuke , Harada Mariko , Zendo Takeshi , Sekiya Yuka , Endo Akihito 
Published: January 2025

Abstract
European foulbrood (EFB) is a bee larvae-specific infectious disease and the causative pathogen is Melissococcus plutonius. Broad-spectrum antibiotics have classically been used in many countries to control the pathogens; however, their use in apiaries was discontinued in several countries due to concerns regarding the health of bees and humans. Therefore, the development of alternative treatments for use in apiaries that are safe for bees and humans is essential. The present study examined the effects of nisin A supplementation using artificially reared honey bee larvae infected by M. plutonius strains. The results obtained showed that a non-purified nisin A product was toxic to honey bee larvae, while semi-purified nisin A by removing low-molecular-weight (< 3,000) chemicals was not lethal to honey bee larvae. A larval diet supplemented with the semi-purified nisin A significantly increased the survival rate of larvae infected by M. plutonius. The levels of nisin A required for this rescue differed between the M. plutonius strains used for infection, and 12.5 and 100 µg/mL were required for strain DAT606 belonging to clonal complex 3 and strain DAT561 belonging to clonal complex 12, respectively. This beneficial effect was attributed to the antagonistic activity of nisin A against M. plutonius strains, and the levels of viable M. plutonius strains significantly decreased in the larval gut at the required concentrations. Due to the risks associated with the use of antibiotics in apiaries, food-grade nisin A is a promising alternative to control EFB.
Processing of Ti–5Al–4W–2Fe Alloy Using Different Powder Metallurgy Routes to Improve Its Implementation in Structural Applications
Authors: Essam Mai , Elsayed Ayman , Nasser Ali , Fatahalla Nabil 
Published: January 2025

Abstract
Titanium (Ti) alloys can be thoroughly improved by introducing aluminum (Al) as an

$$\alpha$$

α

-phase stabilizer and tungsten (W) as a

$$\beta$$

β

-phase stabilizer as well as iron (Fe) for enhancing the strength and the creep resistance. In the current study, Ti–5Al–4W–2Fe alloy was especially synthesized to meet the essential requirements of the structural products of Ti-based alloys. Three different PM routes have been adjusted for investigating both densification and mechanical properties improvement of this alloy. The first approach was pressure-less vacuum sintering (PLS) at 1100–1300 °C for 1 h, which showed inadequate achievement of densification. Unfortunately, using PLS 96% of the theoretical density (TD) was recorded. However, using hot pressing (HP) and sintering-forging (IF) resulted in a successful full densification of 100% TD. It is worth mentioning that adding W particles resulted in an effective grain refinement of the sintered Ti alloy. More interestingly, HP-sintered specimens demonstrated higher strength and plastic compression compared to the other specimens. For instance, the yield and fracture strength of this specimen showed 1463 MPa and 2408 MPa, respectively, which is considered as a remarkable achievement compared to similar studies. Surprisingly, the most economical technique PLS sintering led to the best hardness of 700 HV, compared to 470 HV and 480 HV for the forged specimen and the HP-sintered specimen, respectively.
Naming Māori Learning Spaces
Authors: Stewart Georgina Tuari , Benade Leon , Smith Valance , Wells Alastair , Yates Amanda 
Published: January 2025

Abstract
Following up on our recent article in this journal, this research note discusses the range of names used in Māori school settings for flexible learning spaces (FLS) and innovative learning environments (ILE), There are various existing Māori names for FLS/ILE, which fall into two types: individual names and category names. We consider several of these names as a way to explore this concept and provide a background for positing ‘he wāhi ako’ as a generic name for Māori FLS/ILE, which translates into English as ‘Māori learning space(s).’
Evaluating the interaction between human and paediatric robotic lower-limb exoskeleton: a model-based method
Authors: Sarajchi Mohammadhadi , Sirlantzis Konstantinos 
Published: January 2025

Abstract
Lower-limb exoskeletons (LLEs) have shown potential in improving motor function in patients for both clinical rehabilitation and daily life. Despite this, the development and control of pediatric exoskeletons remain notably underserved. This study focuses on a unique pediatric robotic lower limb exoskeleton (PRLLE), tailored particularly for children aged 8–12. Each leg of the robot has 5 Degrees of Freedom (DOFs)—three at the hip and one each at the knee and ankle. The interaction between the child user and the PRLLE is intricate, necessitating adherence to essential requirements of comfort, safety, and adaptability. Testing numerous prototype variations against diverse user profiles, particularly for children with neurological disorders where each child differs, is impractical. Model-based methods offer a virtual testbed that is useful in the design stage. This study uses MATLAB® to simulate and evaluate the interaction between users and PRLLE after deriving the nonlinear dynamic model of the PRLLE, which is simplified through multiple layers. To verify the accuracy of the derived dynamic model, a Computed Torque Control method is employed. The study provides detailed outcomes for children aged 8, 10, and 12 years, for passive and active users along with variations in PRLLE assistance levels. The study shows significant reductions in human joint torques, up to 56%, alongside substantial actuator powers, reaching up to 98W, for a 10-year-old child user. Furthermore, examining 8 and 12-year-old child users revealed variations in interaction forces, with changes up to 29.5%. Consequently, meticulous consideration of the human user’s limitations is crucial during the PRLLE’s design and conceptualization phases, particularly for PRLLEs.
When Random Practice Makes you More Skilled: Applying the Contextual Interference Principle to a Simple Aiming Task Learning
Authors: Cretton Alexandre , Ruggeri Paolo , Brandner Catherine , Barral Jérôme 
Published: January 2025

Abstract
Contextual interference (CI)—the practice of tasks in a random rather than blocked order—is known to impair immediate performance while enhancing long-term learning and transfer. In simple aiming tasks, CI has been shown to improve movement accuracy. However, whether these greater improvements extend to unpracticed parameters, such as novel distances or the contralateral hand—a relationship informed by schema theory—remains unexplored. Additionally, in non-sequential tasks, CI has been shown to affect processes that are preprogrammed before movement initiation, leaving reaction time and speed unaffected, yet this has not been empirically tested in simple aiming tasks. To address these gaps, we trained thirty-six participants over nine sessions on a computer-based aiming task involving three target distances. Participants were assigned to either a High Contextual Interference (HCI) group, practicing distances in random order, or a Low Contextual Interference (LCI) group, practicing in a blocked order. Performance was assessed in pretest, posttest, and retention sessions under both conditions, with evaluations extending to untrained parameters, including new distances and the contralateral hand. Despite reduced accuracy during training, the HCI group demonstrated significantly higher accuracy in retention and transfer tests compared to the LCI group across both trained and untrained parameters. Consistent with our hypothesis, no differences were observed in reaction time or movement speed, supporting that in simple aiming tasks, CI primarily affects pre-movement initiation processes. These findings confirm the robustness of CI effects in parameterization learning and extend its benefits to unpracticed motor parameters in simple aiming tasks.
Designing and prototyping of a reconfigurable segmented fan concrete shell as a flooring system
Authors: Nuh Mishael , Oval Robin , Orr John 
Published: January 2025

Abstract
A significant portion of the environmental impact of a building’s superstructure lies in its structural flooring. By leveraging funicular forms such as thin concrete shells, a materially and carbon-efficient alternative to bending-active flooring systems can be attained. In addition, through segmentation and the use of dry jointed interfaces, a segmented concrete shell allows for ease of disassembly compatible with circular economy principles for the built environment. This paper presents a novel segmented concrete shell flooring system that leverages the symmetry of revolution of the classical fan vault form to facilitate future design flexibility through increased reconfigurability. The design and form-finding of the segmented fan concrete shell are detailed through the use of an evolutionary algorithm and finite element analysis. Quarter-scale prototypes were digitally fabricated using a robotic concrete spraying process which were then assembled and tested to assess its structural potential, evaluate the limitations, and identify areas of future work. An embodied carbon analysis demonstrates that the system provides a mass and embodied carbon saving compared to conventional flooring systems while adding approximately a 20% embodied carbon premium over a comparable non-reconfigurable segmented shell flooring system. Rephrased, the proposed system provides a positive embodied carbon saving if enabling design flexibility through reconfiguration increases the life-span of the system by at least 20%. Through this work, it is shown that a segmented fan concrete shell presents a viable lightweight and carbon-efficient flooring system which has the potential to become a sustainable alternative that enables disassembly, reuse, and even reconfigurability for circular construction provided further research and development to address its current limitations for adoption in industry practices.
Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma
Authors: Xiu Jing-Ying , Chen Yu-Ning , Mao Ya-Li , Luo Jing-Ting , Li Hao-Wen , Li Yang , Wei Wen-Bin 
Published: January 2025

Abstract

Purpose
Uveal melanoma (UM) is the most common intraocular malignancy in adults. Previous studies have examined the intra-tumoral heterogeneity. However, the spatial distribution of tumor cells within the tumor microenvironment and its relationship with tumor progression still remains largely unclear. Our study aimed to analyze the correlation between cell distribution patterns and the prognosis of UM.

Methods
In this paper, we performed spatial transcriptomics (ST) sequencing on two UM samples to describe the different cellular distribution patterns. Gene Ontology (GO) and Kyoto Encyclopedia of Genes, Genomes (KEGG) functional enrichment analysis, and protein–protein interaction (PPI) network were performed to define the biological function of each cluster. Differentially expressed genes (DEGs) and survival analysis based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database further confirmed the correlation between cellular distribution and clinical prognosis.

Results
We found two different patterns of tumor cell distribution. The focal tumor cells have a distinct ribosome synthesis and rRNA pathway. In contrast, the subpopulation tented to distribute diffusely was related to fatty acids metabolism profile, presumably supporting tumor growth by providing energy. The scattered tumor cell cluster was associated with malignant biological behaviors and was involved in extensive cellular interactions, including COLLAGEN. Moreover, pseudo-time analysis showed that migration started from the basal region through cell differentiation. According to the TCGA and GEO database, genes expressed characteristically in the scattered tumor cell cluster were related to poor prognosis.

Conclusions
Our study drew the ST maps for UM for the first time. These findings revealed the distribution patterns of tumor cells associated with different biological functions and pointed towards specific tumor subpopulations with higher invasiveness as potential therapeutic targets. Together, our study displayed an overview of UM transcriptome and explored the intra-tumoral heterogeneity of UM at the spatial level.
Phase change memory programming circuit with improved speed
Authors: Yang Xinyu , Lei Yu , Yu Qiuyao , Wang Qian , Chen Houpeng , Song Zhitang 
Published: January 2025

Abstract
Phase change memory (PCM) is considered one of the most promising next-generation non-volatile memory types for storage-class memory due to its many advantages, including ultrafast programming, long data retention, high storage density, low power consumption, and compatibility with standard CMOS processes. However, in conventional PCM programming circuits, the first programming operation after power-on suffers from a slow rise time in the programming pulse due to the lack of bias voltage pre-charging in the current source circuit, which leads to reduced consistency in the programming of phase change cells. In this study, we developed two solutions to address the issue associated with conventional PCM programming circuits. We also analyzed conventional programming circuit schemes and designed a PCM programming circuit with improved speed using the SMIC 40 nm CMOS process. The results demonstrated that compared with conventional programming circuits, the PCM programming circuit with improved speed reduced the rise time of SET pulses from 29.6 ns to 7.3 ns and the rise time of RESET pulses from 13.6 ns to 3.1 ns. In addition, it improved the consistency of the programming phase change cells and reduced the power consumption from 11.93 mW to 10.35 mW.