bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life of Mothers of Children born with Cleft Palate in Jordan
Authors: Qatamin Buthainah , EL-HNEITI Mamdouh , Shehadeh Jumna , Elfalah Mutasem , Hamdan-Mansour Ayman 
Published: March 2023

Abstract
The purpose of this paper was to investigate sociodemographic predictors of quality of life of mothers of children with cleft palate, and to compare quality of life between mothers of children without cleft palate and those of children without cleft palate in Jordan. A cross-sectional correlational study was conducted at one specialized Cleft Palate Unit using convenience sample of 312 mothers of children with and without cleft palate. The study used a self-reported questionnaire of two parts; socio-demographic; and WHOQOL- BREFF, Arabic version respectively. Analysis revealed that there was significant difference in environmental quality of life between mother with cleft palate child and those without cleft palate child. Mother’s physical quality of life was significantly predicted by their age, and educational level. Mother’s environmental quality of life was significantly predicted by their social status, and educational level. in conclusion mothers of children with CLP need psychosocial support at societal and institutional levels. Counselling and enhancement of positive coping mechanism are among the most important topics to be addressed to improve mothers' quality of life.
Probabilistic Seismic Hazard for the United Arab Emirates Using Integrated Seismic Source Model
Authors: Barakat Samer A. , Arab Mohamed G. , Awad Raghad A. , Malkawi Dima A. Husein , Metawa Abdulrahman , Omar Maher 
Published: March 2023

AbstractImproving knowledge of active faults encouraged researchers to include faults as seismogenic sources in probabilistic seismic hazed assessments (PSHA). In the current study, a PSHA analysis for the United Arab Emirates (UAE) was conducted using faults along with area seismic sources utilizing a logic-tree framework. Seismicity is evaluated in terms of spectral acceleration (SA) and Peak ground acceleration (PGA) for return periods of 2,475, 975, and 475 years. The results are compared with seismic hazard levels from previous PSHA studies using area sources. The effect of the fault is apparent towards the northeastern side of UAE since the increase in the slip rate of the Dibba fault compared to the rest of the faults contributed to the increase in the seismic hazard in the vicinity of the fault. Contour maps for the SAs at 0.2 and 1.0 s and PGA are developed to be used for the seismic hazard design in the UAE. The largest seismic hazard is estimated in the northeastern borders of UAE at the coastal area of Ras-Al Khaimah with PGA 0.22g for a return period of 2,475 years.
Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling
Authors: Cardona-Benavides Ignacio , Misiewicz-Krzeminska IRENA , Rojas Elizabeta A. , de Ramón Cristina , Sanz-Solas Antonio , Isidro Isabel , Quwaider Dalia , López-Guerrero Aida , Cuadrado Myriam , Calasanz Maria José , Rosiñol Laura , Martínez-López Joaquin , Miguel Jesus San , Manteca Maria Victoria Mateos , Corchete Luis Antonio , GUTIERREZ NORMA 
Published: March 2023

Abstract
Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in MM, but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis of cyclin D proteins using a capillary electrophoresis nanoimmunoassay in newly diagnosed MM patients.
Exclusive expression of cyclin D1 and D2 proteins was detected in 54/165 (33%) and 30/165 (18%) of the MM patients, respectively. It is of note that cyclin D1 or D2 proteins were undetectable in 41% of the samples. High levels of cyclin D1 protein were strongly associated with the presence of t(11;14) or 11q gains. However, cyclin D2 protein was detected in all the cases bearing t(14;16), but in only 24% of patients with t(4;14). The presence of cyclin D2 was associated with shorter OS (HR=2.14, p=0.017), although patients overexpressing cyclin D2, but without 1q gains, had a favorable prognosis.
In conclusion, although one of the cyclins D is overexpressed at the mRNA level in almost all MM patients, in approximately half of the patients this does not translate into detectable protein. This implies that cyclins D could not play an oncogenic role in a proportion of patients with MM.
A multi-criteria decision-making is the ANP network analysis process for identification relief centers in urban areas: A case of study Tabriz city, Iran
Authors: Ghalehteimouri Kamran Jafarpour , Khaliji Mohammad Ali 
Published: March 2023

Abstract
Cities' growing populations and densities create an atmosphere that is conducive to changes in their structure. Accordingly, factors that increase the number of vulnerable groups, such as women, children, the elderly, and people with disabilities, include urban population growth, high-rise buildings, apartment living, industrial concentration, the growth of impoverished neighbourhoods, and informal settlements. Given the earthquake-prone regions of northwest Iran and the frequency of earthquakes in this region in recent years, it is essential to comprehend the characteristics of the natural environment in order to determine the optimal place for the development of urban structures and relief centres. The purpose of this study is to locate potential sites for the development of temporary housing and relief operations. This study, whose methodology is survey and analysis using the ANP model, has discussed the location of places for the establishment of rescue centres and temporary housing for the population according to the physical, environmental, and social criteria, which immediately after the earthquake, the possibility of rescuing the lives of those who witnessed the accident, and the creation of a temporary shelter. The findings indicate that west of Tabriz is the optimum place for the construction of rescue facilities and temporary people settlement based on the distance from natural crisis elements.
Effects of a Collaborative Gamification on Learning and Engagement of Children with Autism
Authors: Silva Laíza , Isotani Seiji , Toda Armando , Challco Geiser , Elias Nassim 
Published: March 2023

Abstract

Gamification, i.e., the use of game elements in non-game contexts, is an effective tool to help children learn using educational technologies. When properly utilized together with pedagogical approaches that foster students' interactions with learning materials, gamification has consistently been shown to increase students' participation, motivation, engagement, and learning gains. Nevertheless, when we consider children with autism, there is little evidence about the benefits of gamification for learning. In addition, to develop gamified educational technologies for this public, it is necessary to know a method of psychology, and few practitioners in this area have this knowledge. A collaborative design in which the collaborators come from different knowledge backgrounds, known as co-design, may deal with this issue. We conducted a single-subject design experiment to assess the effect of a gamified co-design. In this co-design, one practitioner in game design and two psychology experts in autism elaborated a prototype of an application, and DTT (Discrete Trial Training) approach was used to support the learning activities. DTT is a psychology method that demonstrated effectivity in children with autism, and it is based on the use of response to stimuli through repetition and reinforcement. Findings indicated that the developed prototype fosters correct answers, reduces undesired behaviors, follows ABA (Applied Behavior Analysis) skills, and presents positive behaviors. We concluded that co-design is a promising approach to be used in gamification in a context that requires expert knowledge, as ASD (Autism Spectrum Disorder).
Infant-type hemispheric glioma occurring at the cervicomedullary region in a 5-month-old infant: A case report with a special emphasis on molecular classification
Authors: Yamada Erika , Muroi Ai , Suzuki Ryoko , Kino Hiroyoshi , Sakamoto Noriaki , Tsurubuchi Takao , Ishikawa Eiichi 
Published: March 2023

Abstract
High-grade gliomas in infancy are uncommon and have different clinical and molecular characteristics of those in adults. Recently, advances in molecular diagnostics have made progress in determining treatment strategies; however, the robust treatment has not yet been elucidated. We herein present a case of glioma occurring at the cervicomedullary region in a 5-month-old infant who developed left upper limb weakness and torticollis at 3 months of age. Magnetic resonance imaging revealed T2 hyperintensity from the medulla oblongata to the upper cervical cord. She underwent biopsy for the lesion and pathological examination findings confirmed the presence of a high-grade astrocytoma with IDH wildtype-, H3K27M wildtype-, BRAF wildtype-, and ETV-NTRK3 fusion-positivity. Postoperatively, she underwent chemoradiotherapy, but she had marked tumor growth during the treatment. According to the new World Health Organization classification, the patient’s tumor is an infantile “hemispheric” glioma. Although the characteristics and prognosis of NTRK-fused glioma are not fully understood, it is noteworthy that these tumors commonly occur in the brainstem. Further studies are needed to determine the prognosis of each tumor type and its sensitivity to treatment. This information will help in the reclassification of the tumors and identification of the precise treatment of this rare type of tumor.
Affordable panel of techniques for prediction of molecular classification of a series of medulloblastomas in a reference pediatric hospital in Colombia
Authors: Salazar Linda Paola Bárcenas , Gaviria-Delgado Diana , Guerrero María Fernanda , Osorio Luz Karime , Alvarez Rosario , Cabrera Edgar , Olaya Natalia 
Published: March 2023

Abstract
Molecular classification of medulloblastomas helps in improving risk-stratification. However, application in routine practice remains a challenge in low and middle-income countries. In Colombia, children often have delayed and uncomplete diagnosis. We underwent a retrospective analysis of 49 cases of medulloblastoma treated between 2009 and 2017 in a reference pediatric hospital in Bogotá, Colombia. This manuscript reports the use of a immunohistochemical plus PCR panel to distinguish SHH, WNT, and non-SHH/WNT tumors and details their clinical and pathological features. We analyzed Beta-catenin, p75NTR, PIGU, OTX2, YAP1 and P53 by immunohistochemistry and performed PCR for C-myc and N-myc amplification. We found a high percentage of SHH tumors and a high prevalence of desmoplastic-nodular tumors in our series. The male: female ratio was different from reported in other latitudes. We believed it would be important to complement these results by new generation sequencing and the gold standard in the medulloblastoma diagnosis, the methylation analysis. However, the panel we propose is useful to predict the molecular group. This is the first medulloblastoma case series in Colombia.
Novel Prognostic Model of Ferroptosis in Colon adenocarcinoma
Authors: yu qian , pang jianyu , Chen Yongzhi , qi qi , Tang Yuheng , Sheng Miaomiao , tang Wenru 
Published: March 2023

Abstract
One of the most frequent gastrointestinal cancers in the world is colorectal cancer (Coad). Iron degradation might be caused by an imbalance in intracellular iron metabolism. The modification of the immune milieu and the success of tumor immunotherapy are both significantly impacted by hypertrophy. The onset and progression of cancer are both impacted by the imbalance of iron metabolism. My study is now heavily focused on how to use ferrite in conjunction with immunotherapy to prevent the growth of colon adenocarcinoma.Unknown potential indicators of iron metabolism and immunological control in COAD still exist. We used LASSO regression to model the best iron death prognosis in COAD patients, and survival analysis and ROC curves were used to assess the predictive value in the training cohort and external validation cohort. We carried out pathway analysis and immune infiltration to confirm the efficacy of our model and to identify the prognostic indicators that we are interested in. Additionally, we demonstrated the intermolecular interactions between the prognostic molecule and hundred of other chemicals using batch molecular docking. In this manner, useful therapeutic compounds can be discovered.
Different emotion regulation strategies mediate the relations of corresponding connections within the default-mode network to sleep quality
Authors: Chen Yang , Zhang Li , Yin Huazhan 
Published: March 2023

Abstract

Despite a long history of interest in the relation of emotion regulation (ER) to sleep quality, how ER is linked with sleep quality at the neural level is still poorly understood. Accordingly, we adopted the resting-state functional connectivity (rsFC) analysis to identify the neural bases linking ER with sleep quality. 183 young adults (51.7% females,Mage= 22.16) were guided to undergo the MRI scans and then complete the Pittsburgh Sleep Quality Index (PSQI) and the emotion regulation Questionnaire (ERQ) formed by two dimensions: cognitive reappraisal and expressive suppression. Results found that ER mediated the association between functional connectivity within intrinsic default-mode network (DMN) and sleep quality. Specifically, rsFC analysis showed that cognitive reappraisal was positively correlated with rsFC within DMN, including left superior temporal gyrus (lSTG)-left lateral occipital cortex (lLOC), lSTG-left anterior cingulate gyrus (lACG), right lateral occipital cortex (rLOC)-left middle frontal gyrus (lMFG), and rLOC-lSTG. Further mediation analysis indicated a mediated role of cognitive reappraisal in the link between the four connectivity and sleep quality. In addition, expressive suppression was positively correlated with rsFC within DMN, including left precuneus cortex (lPrcu)-right Temporal Pole (rTP) and lPrcu- lSTG. Further mediation analysis indicated a mediated role of expressive suppression in the link between the two connectivity and sleep quality. Overall, this finding supports the process model of ER, in that the effects of reappraisal and suppression have varying neural circuits that impact that strategy’s effect on sleep quality.
Effect of acupuncture treatment on clinical outcomes for cervical disc herniation after minimally invasive surgery: a comparative study
Authors: Li Shun , Hu Jiaqi , Wan Quan , Ji Zhongwei , Zhang Nannan , Zhu Tingli , Ru Bin , Wang Wanchun 
Published: March 2023

Abstract
Purpose: Although percutaneous minimally invasive techniques have been gradually applied to the surgical treatment of cervical disc herniation (CDH), some patients still experience adverse outcomes. The aim of this study was to explore the effect of acupuncture treatment for CDH patients after minimally invasive surgery (MIS).
Methods: We retrospectively reviewed patients with CDH admitted to our department between January 1, 2019 and December 31, 2020. Visual analog scale (VAS), neck disability index (NDI), and the modified MacNab criteria were used to assess pain, function, and clinical outcomes, respectively. Characteristics between patients with acupuncture treatment and those without acupuncture treatment were compared. Logistic regression analysis was performed to investigate the effect of acupuncture treatment on clinical outcomes.
Results: 211 patients were incorporated in the cohort with 102 (48.3%) receiving acupuncture treatment. Patients with acupuncture had a lower postoperative VAS and NDI at one month, six months, and one year (all P < 0.001) after surgery. In addition, acupuncture treatment was associated with lower modified MacNab criteria score at six months and one year (both P < 0.001). Multivariate logistic regression analysis showed that acupuncture (P < 0.001, OR 9.282, 95% CI 3.469-24.836) was an independent factor for good outcomes at one year.
Conclusions: Acupuncture treatment had beneficial effects on relieving pain and improving function in CDH patients after MIS, and was a significant and independent factor for good outcomes at one year after surgery. Acupuncture could be an effective adjunct therapy for CDH patients after MIS.
Complexity Analysis of an Interior-point Algorithm for Cqp Based on a New Parametric Kernel Function
Authors: CHALEKH RANDA , DJEFFAL EL AMIR 
Published: March 2023

Abstract
In this paper, we present a primal-dual interior-point algorithm for convex quadratic programming problem based on a new parametric kernel function with an hiperbolic–logarithmic barrier term. Using the proposed kernel function we show some basic properties that are essential to study the complexity analysis of the correspondent algorithm which we find it coincides with the best know iteration bounds for large-update method, namely, O (√ n log n log n/ε) by a special choice of the parameter p > 1.
Thermo-dynamical random Brownian motion in a slip flow of thermophoretic fluid over a wedge under the influence of variable viscosity and conductivity
Authors: Sreedhar M. , Raju C. S.K. , Khan M. Ijaz , ElDin Sayed M. 
Published: March 2023

Abstract
The article exhibited the impact of variable fluid possessions (temperature dependent viscosity) on nanofluid over a wedge in the presence of heat generation and absorption. We also incorporated the magnetic field, Buogirnio model and nonlinear chemical reaction in this study. It is accepted to take viscosity and thermal conductivity as a reverse capacity and straight capacity of temperature, separately. The governing physical partial differential system (PDE) is transformed into ordinary differential equations (ODEs) and then the subsequent nonlinear ordinary differential conditions are measured numerically utilizing the fourth order of the Runge-Kutta technique jointly with the shooting method. The effect of appropriate parameters concerning the stream capacity has been talked about through charts and tables, together with the necessary disputations/discussion. The friction between the particles is higher in  β= 1/6 compared to β= 0. This help us to conclude that, for higher friction we can use the β= 1/6 case. The heat and mass transmission rate is very low in β= 0 case compared to β= 1/6 case. So, we can conclude that the β=0case useful in cooling and more concentration transferred systems.
Structural characterization of a new amino acid derivatives, Maillard Reaction product of red ginseng and potential protective activity against cisplatin-evoked intestinal injury
Authors: Liu Wei , Zheng Yi-nan , Jiang Shuang , Ren Shen , Tang Shan , Zhang Jing , Wang Zi , Li Wei 
Published: March 2023

Abstract

Based on the Maillard reaction principle of red ginseng (Panax ginsengC.A. Meyer), this study innovatively synthesized a new amino acid derivative by combining arginine with lactose through simulated synthesis, and was separated and purified through repeated silica gel and polyacrylamide gel (Bio-gel P-II) column chromatography. The purity of the product was determined to be 99.86% and its molecular weight was determined to be 497.3612 (negative ion mode) by electrospray ionisation mass spectrometry (ESI-MS). The chemical structure was identified to be 1-(arginine-Nαgroup)-1-deoxy-4-O-(α-D-galactopyranosyl)-D-fructose, named Argininyl-fructosyl-galactose (AFGA, C18H34N4O12). Subsequently, by establishing cisplatin-induced intestinal injury invivoand IEC-6 cell model, the results showed that pretreatment with AFGA significantly ameliorated cisplatin induced oxidative stress by reducing levels of reactive oxygen species (ROS) in IEC-6 cells (p<0.05,p<0.01), and could effectively reduce the secretion of pro-inflammatory factors in serum and the expression level of NF-κB protein in intestinal tissues (p<0.01). Meantime, AFGA also inhibited the expression of p-PI3K/p-Akt, caspase 3, 9, cytochrome C and Bax protein intestinal tissue in mice (p<0.01), and promoted the expression of Bcl-2 protein (p<0.01). Importantly, the molecular docking results of AFGA also suggested a better binding ability with the above-mentioned related target proteins, and further revealed AFGA as a potential multifunctional therapeutic agent with clear protective effect against cisplatin-induced intestinal injury.
Biomechanical study of minimally invasive correction of hallux valgus fixation with absorbable screws: A finite element analysis
Authors: Xu Can , Liu Hua , Li Mingqing , Li Hui , Pan Chun’ang 
Published: March 2023

AbstractBackground Absorbable screws have been applied in clinical practice for the treatment of minimally invasive hallux valgus, but most of the available publications are the results of clinical follow-up, lacking the related biomechanical studies. The aim of this study was to evaluate mechanical responses and stabilities of absorbable screws fixation after the distal metatarsal osteotomy in hallux valgus treatment. Methods In this study, the finite element method was used to construct models of hallux valgus fixation with hallux valgus angles of 30° and 40° using one or two 2.7mm and 4.5mm absorbable screws after osteotomy. Then, the stress of the materials in the bone, the anti-rotation performance, and the inter-fragmentary strain (IFS) results were analyzed by finite element analysis. Results The stress results for the two fixing methods with hallux valgus angles of 30° and 40° under the two working conditions are within the safe range under all conditions. It was also found that the screws had excellent anti-rotation performance whether the osteotomy fragment was fixed with two 2.7mm or one 4.5mm absorbable screws. All the results of inter-fragmentary strain are in the range between 0.9% and 11% which is suitable for bone healing. Conclusions The results indicate that using two 2.7mm screws or one 4.5mm screw to fix the first metatarsal minimally invasive osteotomy can both achieve satisfactory mechanical effect. There was not much difference in the simulation effect between the two fixation methods, and either method can be selected indiscriminatingly in clinical application.
Novel Carbon Nanozymes with Enhanced Phosphatase–like Catalytic Activity for Antimicrobial Applications
Authors: Nurtay Lazzat , Benassi Enrico , Nazir Faisal , Dastan Dana , Utupova Assem , Dautov Adilet , Dukenbayev Kanat , Xie Yingqiu , Pham Tri T. , Fan Haiyan 
Published: March 2023

Abstract
In this work, Sulfur and Nitrogen co–doped carbon nanoparticles (SN–CNPs) were synthesized by hydrothermal method using the dried beet powder as the carbon source. TEM and AFM images indicated that these SN–CNPs form a round-shape ball with an approximate diameter of 50 nm. The presence of Sulfur and Nitrogen in these carbon-based nanoparticles was confirmed by FTIR and XPS analyses. These SN–CNPs were found to have strong phosphatase–like enzymatic activity. The enzymatic behavior of SN–CNPs follows the Michaelis–Menten mechanism with greater vmax and much lower Km values compared to alkaline phosphatase. Their antimicrobial properties were tested on E. coli and L. lactis, and values of MIC were identified as 47-µg mL–1 and 188-µg mL–1, respectively. SEM and AFM images of fixed and live E. coli cells showed that SN–CNPs strongly interacted with the outer membranes of bacterial cells, which greatly increased the cell surface roughness. The chemical interaction between SN–CNPs and phospholipid modeled using quantum mechanical calculations further support our hypothesis that the phosphatase and antimicrobial properties of SN–CNPs are due to the thiol group on the SN–CNPs, which is a mimic of the cysteine–based protein phosphatase. The present work is the first to report carbon–based nanoparticles with phosphatase activity and propose a phosphatase natured antimicrobial mechanism. This novel class of carbon nanozymes has the potential to be used for effective catalytic and antibacterial applications.