bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDI IN SILICO SENYAWA AKTIF KAYU JAWA (Lannea Coromadelica) SEBAGAI ANTIINFLAMASI MELALUI PENGHAMBATAN MEDIATOR TNF-α DAN COX-2
Authors: Syarif Sukmawati 
Published: July 2023

Kayu jawa (Lannea coromandelica) merupakan salah satu tanaman yang banyak digunakan secara empiris oleh masyarakat di Sulawesi Selatan sebagai obat tradisional karena memiliki efek farmakologis seperti antiinflamasi yang merupakan respon protektif normal terhadap berbagai proses fisiologis di dalam tubuh serta memiliki efek biologis yang dapat bekerja pada target molekul. Inflamasi adalah respon perlindungan normal terhadap cedera jaringan yang disebabkan oleh trauma fisik, bahan kimia berbahaya, atau agen mikrobiologi. Tujuan penelitian ini adalah untuk mengetahui senyawa kimia apakah pada tanaman Kayu jawa (Lannea coromandelica) yang berpotensi sebagai antiinflamasi dengan mekanisme penghambatan reseptor TNF-α dan COX-2. Metode penelitian ini adalah in silico menggunakan metode molecular docking dengan perangkat lunak Autodock. Tahapan penelitian antara lain simulasi doking reseptor dengan ligan uji kemudian di validasi, setelah itu di visualisasi menggunakan discovery studio, kemudian dilanjutkan pada tahapan data analisis serta prediksi ADME. Adapun hasil penelitian Senyawa 3-hydroxy-4’,5,7-trimethoxyflavanone terhadap COX-2 dan senyawa uji morin terhadap TNF-α berpotensi sebagai antiinflamasi dengan kemampuan lebih rendah dibandingkan dengan liga alami untuk berkatan dengan sisi aktif pda reseptor target. Selanjutnya penelitian ini diharapkan menjadi pilot project produksi sediaan obat antiinflamasi yang dapat digunakan oleh masyarakat luas
Analgesic effects of oxycodone hydrochloride injection after laparoscopic cholecystectomy and influence on substance P, 5-hydroxytryptamine, and patient-controlled intravenous analgesia
Authors: Tan Lei , Fan Qiannan , Chen Yue , Wu Hao , Xu Huanxi , Zhong Mingjie , Wu Lei 
Published: July 2023

Abstract

Introduction
We sought out to evaluate the effects of oxycodone hydrochloride injection on laparoscopic cholecystectomy (LC), substance P, 5-hydroxytryptamine (5-HT), and patient-controlled intravenous analgesia (PCIA).

Materials and Methods
A total of 120 eligible patients were randomly divided into an observation group (n=60) and control group (n=60). Oxycodone (0.07 mg/kg) and fentanyl (0.7 μg/kg) were intravenously injected during LC. Substance P and 5-HT were detected by ELISA.

Results
Heart rate (HR), mean arterial pressure (MAP), and blood oxygen saturation (SpO2) were recorded. Visual analogue scale (VAS), Ramsay scores, and incidence rates of adverse reactions were recorded. The observation group was less prone to agitation, with less affected HR, MAP and SpO2 during recovery. Before and after extubation, and upon leaving the recovery room, substance P and 5-HT increased more slowly in the observation group. After extubation, the control group had higher VAS and Ramsay scores and a higher incidence rate of adverse reactions. Using oxycodone before the end of LC does not delay awakening or affect extubation, but reduces hemodynamic fluctuations, incidence of agitation and release of substance P and 5-HT. It has high safety and stable circulation during recovery.

Conclusions
Oxycodone used in PCIA after LC effectively mitigates postoperative pain, with milder adverse reactions, which is superior to fentanyl.
Demographic transition - Global population patterns and trends: The case of Albania
Authors: Kiri Lindita 
Published: July 2023

AbstractThe demographic transition means the transition from a traditional mode of demographic balance with high mortality and fertility, to a different mode of balance (modern) with low mortality and fertility throughout the course of the modernization of demographic processes. The demographic transition is associated with changing the indicators of population reproduction and the demographic balance regime. It is a process that the population of every country goes through. What is the demographic transition model based on historical stages? What are the global population trends? What are the characteristics of the demographic transition in Albania? The methods used in this manuscript are those of analysis, synthesis, comparison, etc. The demographic transition model has a global historical-geographical analysis value as it provides a global population assessment trend. The global population trend is towards the phenomenon of aging through decline or birth control and includes both central and semi-central countries. The analysis of the overpopulation in the territory has in essence the interventions by means of different measures to regulate the demographic regimes in function of the well-being of the population. In Albania, the transition has been accompanied by a large drop in births and high emigration. The time has come for this transition to be treated with priority as it affects the country’s economy and its perspective.
Hydrogeochemical characterization of the areas of exploitation of the CBG sites: cas of the plateaus of N'Dangara and Boundou Wandé, Sangarédi sub-prefecture, Prefecture of Boké, Republic of Guinea
Authors: Diallo Yaya Kenda Baïlo , Konaté Ahmed Amara 
Published: July 2023

Abstract
This work aims to analyze the quality of groundwater in the riparian areas of the bauxitic plateaus of N'Dangara and Boundou Wandé in operation by the CBG (Compagnie des Bauxites de Guinée). The geology of the study area consists mainly of sedimentary formations of the Devonian faro, Neogene and Quaternary. Three water measurement and sampling campaigns on the two plateaus were carried out with determination of piezometric measurements and physic-chemical parameters. This study showed that the general flow direction of groundwater is dispersed. The flows at Boundou Wandé are from the center of the plateau to the north and that at N'Dangara is from the center to the south and southwest. It can be seen that the direction of groundwater flow reflects overall the relief of the deposit conditioned by its geomorphological framework. It emerges from the analysis of physical and chemical parameters that well water is consumable. However, the water from wells MW15, MW16, MW17, MW18 and MW21 with a low pH (4.84 to 5.13) may present a certain nuisance for its consumption and because it can be corrosive. Analysis of the Piper diagram showed two hydrogeochemical facies (calcium and magnesium bicarbonate facies and sodium and potassium carbonate facies). However, this study strongly suggests continuous monitoring of groundwater in and around the study area in order to meet the demand for water supply to communities without compromising the ability of future generations to meet water quality requirements.
Natural Resources. Cycle of substances in nature. Implementation of ecological education and formation of ecological culture in the studies of “Man and Nature” and “Chemistry and Environmental Protection”
Authors: Vasileva-Tcankova Radostina Strahilova 
Published: July 2023

Abstract
Throughout a long historical period, the natural resources of the world have been managed by different human communities. Living within the boundaries of their own ecosystems forces people to develop a deep knowledge of managing their natural resources. Whether they and their children will survive directly depends on their behavior. People have given the land and natural resources a social and symbolic value that goes beyond their immediate use value. This symbolism is based on ecological principles and supports a system of ethical, social and economic rules that are adaptive. This means that these principles and rules help human communities prevent the overexploitation of natural resources, preserve their connections with the surrounding ecosystems, so that people can live within the limits imposed by the availability of resources and technology.
Over the course of the last few generations, however, the world's diversity of cultures, along with their adaptations to local environmental conditions, has been rapidly disintegrating under the influence of a new, global culture characterized by extremely high levels of consumption. Economic growth based on fossil fuel energy led to the rapid development of industry and international trade, and improved lifestyles as well as advances in health care led to rapid growth in human population and consumption. As a consequence, the search for new ways of extracting resources, involving powerful machines and efficient technologies, which absorb the traditions of conservation of nature built by local human communities during their long historical experience of survival, is intensified.
Mechanisms developed as adaptations to the environment over hundreds of years are rapidly breaking down as a result of globalization, thereby freeing humans from their traditional environmental constraints.
Education for sustainable development - analysis and findings
Authors: Doychinova Klaida 
Published: July 2023

Abstract
Education is defined as a major tool for raising awareness of the principles and functions of sustainable development. The problem of sustainable development, environmental and health education is subject to standards defining both content parameters in subject areas, overlapping integral fields, and options for implementation in pedagogical practice. The article presents an analysis of the problem of climate and energy efficiency, which is present only implicitly within the State educational standard for general education and curricula within the framework of the key competence common to all subjects - skills to support sustainable development and healthy lifestyle and sport.
Teaching methods based on constructivism in environmental education
Authors: Doychinova Klaida 
Published: July 2023

Abstract
The traditional educational paradigm is increasingly giving way to active learning and the various possibilities for its application, which methodological basis is constructivism. They are all part of integrative learning, expressed in the creation of sustainable interdisciplinary connections. Constructivism is associated with key competencies for lifelong learning, necessary for ensuring a sustainable and adaptable to changes educational environment. This in turn requires a change in the teaching model and the application of technologies and approaches adjusted to these changes in the learning process. Part of these methods, that are successfully applied in problem-based, ecological education is project-based, and cooperative learning.
The influence of percussion massage on knee’s range of motion in two positions
Authors: Klimowska Natalia , Jaskulski Karol , Zdrodowska Agnieszka 
Published: July 2023

Abstract

Study aim: The practical application of vibration stimuli is increasingly observed in physiotherapy and sports. The aim of the study was to investigate the effects of local vibration on knee-joint range of motion (ROM) improvement among male American football players.

Materials and methods: The study consisted of 31 participants (age 22.9 ± 4.3), divided by knee injury (KI) history and nKI (no knee injury). The intervention involved the use of vibration on parts of the quadriceps muscle with a 10-second vibration and 5-second intermission protocol. ROM measurements were conducted in the prone position (PrP) before the intervention, immediately after, and after 10 minutes, as well as in the half-kneeling position (HkP) before and immediately after.

Results: Knee ROM increased immediately after (p < 0.001) and 10 minutes after (p < 0.05) the intervention in nKI in the PrP, and there was a statistically significant improvement in the HkP (p < 0.001). There was no significant interaction between ROM in PrP and knee injury (F2,58 = 8.562; p < 0.001), but there were significant differences in the ROM before (KI: 133.9° ± 6.26°; nKI: 144° ± 4.06°), immediately after (KI: 137.3° ± 6.98°; nKI: 145.9° ± 4.64°), and 10 minutes after (KI: 136.7° ± 6.75°; nKI: 145.6° ± 4.5°) the intervention. There was no significant interaction between ROM measurement in HkP and knee injury. There was a statistically significant difference in ROM (F1,29 = 33.76; p < 0.001) before (KI: 141.4° ± 7.66°; nKI: 146.4° ± 7.17°) and immediately after (KI: 145.3° ± 8.22°; nKI: 150.2° ± 6.32°) the intervention in the HkP.

Conclusions: Local vibration may increase knee ROM by improving soft tissue elasticity.
An Overview on Advances in Injection Moulding Remanufacturing
Authors: Dimitriu Florin , Seghedin Neculai-Eugen , Chitariu Dragoş-Florin 
Published: July 2023

Abstract
The paper presents an overview of injection mold failures and alternatives in repairing these expensive tools. During the injection mold operations the main components are subjected to wear and require some form of repair. The typical defects of the components of the plastic injection moulds are cracks and the typical repair route is presented. Among the analyzed processes, namely TIG welding, plasma welding and laser welding, the laser welding process has a number of advantages that make it suitable for linear repairs, for small moulds and for face repairs. For each process a series of specific advantages but also slightly different fields of application are presented. The most advanced welding repair equipment uses ND: YAG laser technology and the main differences compared to TIG welding are presented.
Designing to Minimize the Influence of Stress Concentrators
Authors: Al-Kisswani Layth , Samara Fayez , Goanţă Viorel 
Published: July 2023

Abstract
In this paper, we will discover the importance of the stress calculation method with the help of finite elements in design. The aim is to reduce the stress concentration factor, and this is achieved by subjecting to analysis several 3D models that highlight different particular cases. It will be possible to observe different finite element analyzes for different bars with different stress concentrators. This way we can compare the different results obtained and we will be able to make a suitable decision in the case of a design calculation, choosing the most advantageous constructive solution.
Determination of Fatigue Crack Propagation Rate by Two Methods
Authors: Samara Fayez , Al-Kisswani Layth , Goanţă Viorel 
Published: July 2023

AbstractIn the paper are present a practical procedure involving the determination of crack propagation rate using da/dN software. The procedure of the tests, the presentation of the da/dN software and its operation, the hypothesis and the conditions of the experiment and the results obtained from the experiment were presented. The determination of the yield strength and elastic characteristics was used, in which the steps for carrying out an experiment in the laboratory were explained. This was carried out by choosing the materials, presenting the apparatus and the specimen to be analyzed, and the results obtained from the experiment. It should be mentioned that da/dN software was used to obtain the results. The paper illustrates the dependencies between crack growth and the number of loading cycles, demonstrated by two experimental methods. The theoretical part underlying the two experimental methods, the calculation relations used, the importance and role of the da/dN software in their realization are discussed, and the conclusions of the study are presented at the end.
Obtaining Metal Parts by Additive Manufacturing, as an Alternative to Traditional Manufacturing Methods – A Review
Authors: Dârlău Lucian-Corneliu 
Published: July 2023

Abstract
The advantages of Additive Manufacturing (AM) over conventional manufacturing processes are incontestable: complex geometries of obtained parts, wide variety of materials (polymers, composites, low melting metal alloys) used, simple and cost-effective process. Material Extrusion (ME) (piston, filament or screw) is the most widespread AM technology. In this paper, a comparative analysis of different materials used in high reinforcement 3D printing is made. Thus, ceramic and metallic composites, composites with titanium particles, AISI M2 high speed steel powder and Nickel 625 alloy are presented. The conclusion of each study is that increasing powder concentration (up to 65%, by volume) increases parts density (up to 90%), improves sintering process, but narrows process parameters. A balance between raw material properties and processing parameters must be sought to obtain custom parts with optimal properties.
A Study on the Influence of Thermal Interface Material in Passively Cooled Electrical Components with Attached Heatsink
Authors: Chiriac George-Gabriel , Dumitraş Cătălin Gabriel , Mertic Ionuţ 
Published: July 2023

Abstract
This paper studies the effect of the presence of a thermal interface material between a heat source and a heat sink. A heat sink is used as a passive cooling device for a thick film heating element used as a heat source. The heating element is fixed using 2 screws. The temperatures are measured in 2 scenarios: first, where the heating element is placed directly on the heat sink, and second, where a thermal pad is placed between the heat source and heat sink. Using a similar CAD model as the one tested and the same boundary conditions, finite element analysis were solved. The goal is to see if the finite element method delivers similar results as the measured ones and if the method is reliable in predicting the thermal behaviour of the electronic components. Temperature measurements show an improvement in heat source cooling when the thermal interface material is placed between the heat source and heating element. Also, the temperatures from the finite element analysis are similar to the measured ones, making the method reliable for similar applications.
Morphological Matrices Application in Case of Location-Positioning Devices with Tiltable Plate
Authors: Munteanu Adriana , Păduraru Emilian , Cioată Florentin , Ciobanu Mădălina 
Published: July 2023

Abstract
The analysis of the methods and devices of measuring and verifying the angular dimensions leads to the conclusion that technologies have been developed and can be further developed for the control of angles between flat surfaces, for the application of which existing control equipment can be used, as well as other types, solutions, variants of technological devices for controlling angular dimensions. This diversity is mainly due to the diversity of the parameters and parts to be controlled and the diversity of the technical systems in which the technological devices are integrated, respectively, their constructive and functional parameters. Morphological matrices are one of the most effective tools for structuring, systematizing, combining, and evaluating existing solutions in this specific field and, it aims to make the research activity more efficient, thanks to its creative potential. The present paper considers the solutions for location-positioning with tilting devices using morphological box and presents the main principial solutions to develop the proper constructive solution in this specific field. Both the spatial and the flat morphological matrix are taken into consideration.
Digital Business Incubators and Digital Entrepreneurship: The case of Digital Incubation Center in Qatar
Authors: Sonia Chetouane , Hania Chetouane 
Published: July 2023

Abstract
This study examines the role of digital business incubators, focusing specifically on the Qatar Digital Incubation Center (DIC), in fostering digital entrepreneurship. The methodology used is qualitative, employing content analysis to interpret textual and visual data from sources such as online databases, documents, reports, and academic research papers. International benchmark reports are used to assess Qatar's global ranking in research, development, innovation, and digital entrepreneurship. The findings highlight Qatar's commitment to digital transformation and its efforts to create a supportive ecosystem for entrepreneurship. They underscore Qatar's dedication to driving innovation through investments in telecommunications, information technology, education, and initiatives like the Qatar National Research Fund. Qatar's digital competitiveness is evident through its ICT infrastructure, extensive 5G implementation, and initiatives like the Smart Qatar Program. The DIC plays a pivotal role in supporting digital entrepreneurs by providing resources, mentorship, and a collaborative environment. By collaborating with government agencies, academic institutions, and industry partners, the DIC contributes to the growth and success of digital startups, fostering innovation, and positioning Qatar as a hub for digital entrepreneurship and technological innovation. This study provides valuable insights into the development of Qatar's digital entrepreneurship ecosystem and the significance of digital business incubators, including the DIC.
The impact of public debt on economic growth in Côte d'Ivoire: New evidence from linear and non-linear ARDL approaches
Authors: Saungwem Talknice , Maluleke Glenda , Odhiambo Nicholas M. 
Published: July 2023

Abstract
This study examines the symmetric and asymmetric impact of public debt on economic growth in Côte d'Ivoire using time series data from 1972 to 2021. The analyses were performed using both linear and nonlinear autoregressive distributed lag (ARDL) models. The study also utilised the bounds F-test for cointegration, the Brock-Dechert-Scheinkman (BDS) nonlinearity test, and the Wald test for asymmetries. The findings of the bounds F-test provide support for both linear and nonlinear cointegration. The BDS test results indicate that the series are nonlinear, while Wald test results revealed an asymmetric relationship between public debt and economic growth in Côte d'Ivoire in the short run and symmetric relationship in the long run. Estimation results for the symmetric ARDL regression model provide no evidence of a statistically significant impact of public debt on economic growth, regardless of whether the analysis was conducted in the short run or long run. The NARDL findings indicate that, on average, positive changes to public debt lead to economic decline in the long run, while negative changes cause an economic upturn in the short run. The findings also show that GDP growth responds rapidly and strongly to negative changes in public debt. Therefore, the study encourages the government of Côte d'Ivoire to be cautious about public debt rise because it was established that they have a negative impact on economic growth. Negative changes in the public debt can serve to minimise the uncertainties in the business environment, thus promoting private, public, and foreign direct investments.
The Effects of Poverty on Health Outcomes in Nigeria: An ARDL Approach
Authors: Abdulrahman Abdulganiyu Idris 
Published: July 2023

Abstract
There is no doubt that individual makes up a nation. Thus, as health is a crucial component of one’s welfare, access to good healthcare is a prerequisite to attaining long-term economic growth that is both sustainable and prosperous. This study looks at the impact of poverty on people’s health in Nigeria. A time series data spanning 29 years, from 1991 to 2021 was used for the study. This data was estimated using Auto Regressive Distributed Lag (ARDL). In order to simulate how poverty affects health outcomes in Nigeria, the study utilized mathematical models to determine whether Nigeria health results (CO2 emission, patients per physician, life expectancy rate, and poverty rate) responds to poverty shock. The study implies that, poverty shock has a big short-term influence on health outcome factors. The study suggested that in order to reduce high mortality rates government should focus more on improvement in health sector, particularly in the areas where there are less hospitals and basic healthcare facilities care is inadequate.