bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial
Authors: Sadri Bahareh , Hassanzadeh Mohammad , Bagherifard Abolfazl , Mohammadi Javad , Alikhani Mehdi , Moeinabadi-Bidgoli Kasra , Madani Hoda , Diaz-Solano Dylana , Karimi Shahedeh , Mehrazmay Mohammad , Mohammadpour Mehdi , Vosough Massoud 
Published: June 2023

Abstract
Background
Intra-articular injection of mesenchymal stromal cells (MSCs) with immunomodulatory features and their paracrine secretion of regenerative factors proposed a noninvasive therapeutic modality for cartilage regeneration in knee osteoarthritis (KOA).

Methods
Total number of 40 patients with KOA enrolled in two groups. Twenty patients received intra-articular injection of 100 × 106 allogeneic adipose-derived mesenchymal stromal cells (AD-MSCs), and 20 patients as control group received placebo (normal saline). Questionnaire-based measurements, certain serum biomarkers, and some cell surface markers were evaluated for 1 year. Magnetic resonance imaging (MRI) before and 1 year after injection was performed to measure possible changes in the articular cartilage.

Results
Forty patients allocated including 4 men (10%) and 36 women (90%) with average age of 56.1 ± 7.2 years in control group and 52.8 ± 7.5 years in AD-MSCs group. Four patients (two patients from AD-MSCs group and two patients from the control group) excluded during the study. Clinical outcome measures showed improvement in AD-MSCs group. Hyaluronic acid and cartilage oligomeric matrix protein levels in blood serum decreased significantly in patients who received AD-MSCs (P < 0.05). Although IL-10 level significantly increased after 1 week (P < 0.05), the serum level of inflammatory markers dramatically decreased after 3 months (P < 0.001). Expressions of CD3, CD4, and CD8 have a decreasing trend during 6-month follow-up (P < 0.05), (P < 0.001), and (P < 0.001), respectively. However, the number of CD25+ cells increased remarkably in the treatment group 3 months after intervention (P < 0.005). MRI findings showed a slight increase in the thickness of tibial and femoral articular cartilages in AD-MSCs group. The changes were significant in the medial posterior and medial anterior areas of ​​the tibia with P < 0.01 and P < 0.05, respectively.

Conclusion
Inter-articular injection of AD-MSCs in patients with KOA is safe. Laboratory data, MRI findings, and clinical examination of patients at different time points showed notable articular cartilage regeneration and significant improvement in the treatment group.
Trial registration: Iranian registry of clinical trials (IRCT, https://en.irct.ir/trial/46), IRCT20080728001031N23. Registered 24 April 2018.
From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications
Authors: Gnesin Silvano , Chouin Nicolas , Cherel Michel , Dunn Steven Mark , Schaefer Niklaus , Faivre-Chauvet Alain , Prior John O. , Delage Judith Anna 
Published: June 2023

AbstractThe development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapolations for effective human translation. The validation of different animal-to-human dosimetry extrapolation methods still is an open issue. This study reports the mice-to-human dosimetry extrapolation of 64Cu/177Lu 1C1m-Fc anti-TEM-1 for theranostic application in soft-tissue sarcomas. We adopt four methods; direct mice-to-human extrapolation (M1); dosimetry extrapolation considering a relative mass scaling factor (M2), application of a metabolic scaling factor (M3) and combination of M2 and M3 (M4). Predicted in-human dosimetry for the [64Cu]Cu-1C1m-Fc resulted in an effective dose of 0.05 mSv/MBq. Absorbed dose (AD) extrapolation for the [177Lu]Lu-1C1m-Fc indicated that the AD of 2 Gy and 4 Gy to the red-marrow and total-body can be reached with 5–10 GBq and 25–30 GBq of therapeutic activity administration respectively depending on applied dosimetry method. Dosimetry extrapolation methods provided significantly different absorbed doses in organs. Dosimetry properties for the [64Cu]Cu-1C1m-Fc are suitable for a diagnostic in-human use. The therapeutic application of [177Lu]Lu-1C1m-Fc presents challenges and would benefit from further assessments in animals’ models such as dogs before moving into the clinic.
A low computation detection method of signal nonlinear distortion based on digital quadrature detection principle
Authors: Wang Peng-Cheng , Huang Xiao-Ping 
Published: June 2023

AbstractThis paper presents a digital low computation detection method for signal nonlinear distortion. After presetting ADC sampling rate and completing data sampling, the low sampling rate data extracted from the sampling data complete the autocorrelation analysis to correct and calculate the accurate fundamental frequency. According to the relationship between the fundamental frequency and the sampling rate, the complete periodic segment data of the signal cutting out from the sampling data carry out the digital quadrature detection operation to obtain the value of each harmonic component and nonlinear distortion. Experiments show that the calculation of this method is less than that of FFT spectrum analysis method when measuring the THD lower than 15 order. When calculating the 15-order THD at 1024 points, the calculation time is reduced by 44.26%. Moreover, the digital quadrature detection method has high measurement accuracy with less than 0.6% error of detecting 5-order THD.
Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries
Authors: Olaru Ioana D. , Walther Birgit , Schaumburg Frieder 
Published: June 2023

Abstract
Background
Antimicrobial resistance is an increasing challenge in low and middle-income countries as it is widespread in these countries and is linked to an increased mortality. Apart from human and environmental factors, animal-related drivers of antimicrobial resistance in low- and middle-income countries have special features that differ from high-income countries. The aim of this narrative review is to address the zoonotic sources and the spread of antimicrobial resistance from the perspective of low- and middle-income countries.

Main body
Contamination with extended-spectrum beta-lactamase (ESBL)-producing Escherichiacoli is highest in poultry (Africa: 8.9–60%, Asia: 53–93%) and there is a risk to import ESBL-producing E.coli through poultry meat in Africa. In aquacultures, the proportion of ESBL-producers among E.coli can be high (27%) but the overall low quality of published studies limit the general conclusion on the impact of aquacultures on human health. ESBL-producing E.coli colonization of wildlife is 1–9% in bats or 2.5–63% birds. Since most of them are migratory animals, they can disperse antimicrobial resistant bacteria over large distances. So-called ‘filth flies’ are a relevant vector not only of enteric pathogens but also of antimicrobial resistant bacteria in settings where sanitary systems are poor. In Africa, up to 72.5% of ‘filth flies’ are colonized with ESBL-producing E.coli, mostly conferred by CTX-M (24.4–100%). While methicillin-resistant Staphylococcus aureus plays a minor role in livestock in Africa, it is frequently found in South America in poultry (27%) or pork (37.5–56.5%) but less common in Asia (poultry: 3%, pork: 1–16%).

Conclusions
Interventions to contain the spread of AMR should be tailored to the needs of low- and middle-income countries. These comprise capacity building of diagnostic facilities, surveillance, infection prevention and control in small-scale farming.

Graphical abstract
Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C]β-hydroxybutyrate ([11C]OHB) PET in healthy humans
Authors: Luong Thien Vinh , Nielsen Erik Nguyen , Falborg Lise , Kjærulff Mette Louise Gram , Tolbod Lars Poulsen , Søndergaard Esben , Møller Niels , Munk Ole Lajord , Gormsen Lars Christian 
Published: June 2023

Abstract
Background
Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the brain and the kidneys. Drug treatments, dietary regimens and oral ketone drinks designed to deliver ketones for organ and tissue energy production have therefore gained popularity. However, whether ingested ketones are taken up by various extra-cerebral tissues and to what extent is still largely unexplored. It was therefore the aim of this study to use positron emission tomography (PET) to explore the whole body dosimetry, biodistribution and kinetics of the ketone tracer (R)-[1-11C]β-hydroxybutyrate ([11C]OHB). Six healthy subjects (3 women and 3 men) underwent dynamic PET studies after both intravenous (90 min) and oral (120 min) administration of [11C]OHB. Dosimetry estimates of [11C]OHB was calculated using OLINDA/EXM software, biodistribution was assessed visually and [11C]OHB tissue kinetics were obtained using an arterial input function and tissue time-activity curves.

Results
Radiation dosimetry yielded effective doses of 3.28 $$\upmu$$
μ
Sv/MBq (intravenous administration) and 12.51 $$\upmu$$
μ
Sv/MBq (oral administration). Intravenous administration of [11C]OHB resulted in avid radiotracer uptake in the heart, liver, and kidneys, whereas lesser uptake was observed in the salivary glands, pancreas, skeletal muscle and red marrow. Only minimal uptake was noted in the brain. Oral ingestion of the tracer resulted in rapid radiotracer appearance in the blood and radiotracer uptake in the heart, liver and kidneys. In general, [11C]OHB tissue kinetics after intravenous administration were best described by a reversible 2-tissue compartmental model.

Conclusion
The PET radiotracer [11C]OHB shows promising potential in providing imaging data on ketone uptake in various physiologically relevant tissues. As a result, it may serve as a safe and non-invasive imaging tool for exploring ketone metabolism in organs and tissues of both patients and healthy individuals.
Trial registration
Clinical trials, NCT0523812, Registered February 10th 2022, https://clinicaltrials.gov/ct2/show/NCT05232812?cond=NCT05232812&draw=2&rank=1.
Elbow hemiarthroplasty with a 3D-printed prosthesis for distal humeral bone defects after tumor excision: a case report
Authors: Zhu Yingkang , Gong Shuo , Dai Jin , Zhou Lei 
Published: June 2023

Abstract
Introduction
The distal humerus is a rare site for primary and metastatic bone tumors. Due to the scarcity of cases and lack of standardized surgical strategies, it is often difficult for surgeons to choose the right choice. The application of a 3D-printed prosthesis with hemiarthroplasty for the treatment of the distal humerus after tumor resection can be a very effective option.

Case presentation
We present a clinical case of a 3D-printed distal humeral prosthesis for the treatment of bone defects caused by metastatic bone tumors. The preoperative evaluation was aggressively performed, and the decision was made to distal humeral hemiarthroplasty (DHH) after wide resection of the tumor segment bone. Processing of the Digital Imaging and Communications in Medicine (DICOM) data from CT scans performed after mirror conversion using CT data of the contralateral humerus, we designed a 3D-printed distal humeral prosthesis with hemiarthroplasty. After reconstruction of bone and surrounding soft tissue by the 3D-printed prosthesis combined with the LARS ligament and regular follow-up for 12 months, the patient had an MSTS-93 score of 29 and an MEP of 100, which reached a good level, and the patient was fully competent in normal daily activities.

Conclusions
Our results show that the 3D-printed modular prosthesis with hemiarthroplasty is a very effective option for cases of large elbow bone defects due to primary bone tumors or metastatic disease. However, careful preoperative preparation is required for the best outcome. Careful preoperative preparation and long-term follow-up are essential for the best outcome.
Re-thinking uterine fibroids in immunocompromised patients: adenomatoid tumors
Authors: Lizardo-Thiebaud Maria José , Andrade-Orozco Guillermo , Cervantes-Álvarez Eduardo , Burbano-Rodríguez Sara , Sánchez-Hernández Beatriz , Hernandez-Frausto Arnoldo , San Martín-Morante Oswaldo , Ángeles-Ángeles Arturo 
Published: June 2023

Abstract
Background
Adenomatoid tumor (AT) is an ambiguous term used to describe benign mesothelial neoplasms, most often reported in organs of the reproductive system. Their neoplastic nature has been proven through the confirmation of pathogenic mutations in TRAF7. Several studies have proven an association between AToU and immunosuppression. Several groups have hypothesized immunosuppression causes an abnormal inflammatory state within mesothelial cells, increasing the likelihood of a selective activating mutations in TRAF7.

Case presentation
A 34 year old female patient with a history of systemic lupus erythematosus was seen in the Emergency Department due to abdominal pain. A diagnosis of uterine leiomyomatosis was made and she was surgically intervened. Macroscopically, several intramural and subserosal uterine nodules were identified. On microscopic examination, all of them except one corresponded to adenomatoid tumours. A somatic mutation in TRAF7 was identified.

Conclusions
Adenomatoid tumors have been associated with immunosuppression. A decrease in immunosurveillance may explain the association between adenomatoid tumours and immunosuppression. Confirming their neoplastic nature is crucial. Further studies are required to characterize the biological significance TRAF7 has in adenomatoid tumours and their association to immunocompromised states.
Estimate measurement errors of household water meters using a large amount of on-site data feedback
Authors: Chen Hsin-Liang , Lo Shang-Lien , Kuo Jeff , Huang Chin-Ling 
Published: June 2023

AbstractWater meter measurement error is considered as one important component of non-revenue water by International Water Association. Its magnitude depends combinedly on users’ consumption behaviors (intake spectrum) and metrological characteristics of water meters (meter error curve). Most published researches have only analyzed the meter error curves without taking the users’ consumption behaviors into consideration. This study developed a practical approach by using the relative difference chart of master-meters and sub-meters groupings (i.e., RM-μz chart) to identify average metering errors for a major water utility company in Taiwan. About 120,000 sets of “master-meter and sub-meter grouping” data of Taipei Water Department were analyzed. The approach successfully estimated average metering errors of its 99.6% domestic meters (around 1.6 million water meters), the results are 9.9, 6.1, and 10.0% less than the actual water consumption recorded by the sub-meters, master-meters, and direct-meters, respectively.
Application of machine learning in the prevention of periprosthetic joint infection following total knee arthroplasty: a systematic review
Authors: Chong Yuk Yee , Chan Ping Keung , Chan Vincent Wai Kwan , Cheung Amy , Luk Michelle Hilda , Cheung Man Hong , Fu Henry , Chiu Kwong Yuen 
Published: June 2023

AbstractBackgroundMachine learning is a promising and powerful technology with increasing use in orthopedics. Periprosthetic joint infection following total knee arthroplasty results in increased morbidity and mortality. This systematic review investigated the use of machine learning in preventing periprosthetic joint infection.MethodsA systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed was searched in November 2022. All studies that investigated the clinical applications of machine learning in the prevention of periprosthetic joint infection following total knee arthroplasty were included. Non-English studies, studies with no full text available, studies focusing on non-clinical applications of machine learning, reviews and meta-analyses were excluded. For each included study, its characteristics, machine learning applications, algorithms, statistical performances, strengths and limitations were summarized. Limitations of the current machine learning applications and the studies, including their ‘black box’ nature, overfitting, the requirement of a large dataset, the lack of external validation, and their retrospective nature were identified.ResultsEleven studies were included in the final analysis. Machine learning applications in the prevention of periprosthetic joint infection were divided into four categories: prediction, diagnosis, antibiotic application and prognosis.ConclusionMachine learning may be a favorable alternative to manual methods in the prevention of periprosthetic joint infection following total knee arthroplasty. It aids in preoperative health optimization, preoperative surgical planning, the early diagnosis of infection, the early application of suitable antibiotics, and the prediction of clinical outcomes. Future research is warranted to resolve the current limitations and bring machine learning into clinical settings.
Banging the drum: evolutionary and cultural origins of music and its implications for psychiatry
Authors: Rafferty Gerry , Brar Gurjot , Petrut Mara , Meagher David , O'Connell Henry , St John-Smith Paul 
Published: June 2023

SummaryThere is growing interest in music-based therapies for mental/behavioural disorders. We begin by reviewing the evolutionary and cultural origins of music, proceeding then to discuss the principles of evolutionary psychiatry, itself a growing a field, and how it may apply to music. Finally we offer some implications for the role of music and music-based therapies in clinical practice.
Real-time air pollution and bipolar disorder symptoms: remote-monitored cross-sectional study
Authors: Kandola Aaron , Hayes Joseph F. 
Published: June 2023

Summary
Air pollution is associated with unipolar depression and other mental health problems. We assessed the real-time association between localised mean air quality index and the severity of depression and mania symptoms in people with bipolar disorder. We found that as air quality worsened, symptoms of depression increased. We found no association between air quality and mania symptoms.
Electrochemical transport in Dirac nodal-line semimetals
Authors: Flores-Calderón R. , Medel Leonardo , Martín-Ruiz A. 
Published: June 2023

Abstract
Nodal-line semimetals are topological phases where the conduction and the valence bands cross each other along one-dimensional lines in the Brillouin zone, which are symmetry protected by either spatial symmetries or time-reversal symmetry. In particular, nodal lines protected by the combined

symmetry exhibits the parity anomaly of 2D Dirac fermions. In this letter, we study the electrochemical transport in

Dirac nodal-line semimetals by using the semiclassical Boltzmann equation approach. We derive a general formula for the topological current that includes both the Berry curvature and the orbital magnetic moment. We first evaluate the electrochemical current by introducing a small

mass term (which could be induced by inversion-breaking uniaxial strain, pressure, or an external electric field) and apply it to the hexagonal pnictide CaAgP. The electrochemical current vanishes in the zero-mass limit. Introducing a tilting term that does not spoil

symmetry that protects the nodal ring, we obtain a finite electrochemical current in the zero-mass limit, which can be regarded as a direct consequence of the parity anomaly. We show that the parity-anomaly–induced electrochemical transport is also present at nonzero temperatures.
High epigenetic potential protects songbirds against pathogenic Salmonella enterica infection
Authors: Sheldon Elizabeth , Zimmer Cedric , Hanson Haley , Koussayer Bilal , Schrey Aaron , Reese Darrys , Wigley Paul , Wedley Amy L. , Martin Lynn B. 
Published: June 2023

ABSTRACT
Animals encounter many novel and unpredictable challenges when moving into new areas, including pathogen exposure. Because effective immune defenses against such threats can be costly, plastic immune responses could be particularly advantageous, as such defenses can be engaged only when context warrants activation. DNA methylation is a key regulator of plasticity via its effects on gene expression. In vertebrates, DNA methylation occurs exclusively at CpG dinucleotides and, typically, high DNA methylation decreases gene expression, particularly when it occurs in promoters. The CpG content of gene regulatory regions may therefore represent one form of epigenetic potential (EP), a genomic means to enable gene expression and hence adaptive phenotypic plasticity. Non-native populations of house sparrows (Passer domesticus) – one of the world's most cosmopolitan species – have high EP in the promoter of a key microbial surveillance gene, Toll-like receptor 4 (TLR4), compared with native populations. We previously hypothesized that high EP may enable sparrows to balance the costs and benefits of inflammatory immune responses well, a trait critical to success in novel environments. In the present study, we found support for this hypothesis: house sparrows with high EP in the TLR4 promoter were better able to resist a pathogenic Salmonella enterica infection than sparrows with low EP. These results support the idea that high EP contributes to invasion and perhaps adaptation in novel environments, but the mechanistic details whereby these organismal effects arise remain obscure.
El camino incompleto hacia la inclusión de una perspectiva de género en la política exterior boliviana (2006-2022)
Authors: Garino María Agustina 
Published: June 2023

En los últimos años, varios Estados han incorporado perspectivas de género en su política exterior. En este artículo se investigó en qué medida la política exterior indigenista de los gobiernos del Movimiento al Socialismo (mas) ha avanzado en la inclusión de un enfoque feminista en el programa internacional boliviano. El análisis de caso se aborda desde los estudios decoloniales y el feminismo comunitario. Se argumenta que la política exterior boliviana (2006-2022), influenciada por el pensamiento indígena andino y la cosmovisión del Buen Vivir, ha brindado las bases programáticas y discursivas para construir una agenda internacional con perspectiva de género que incluya las demandas históricas de las mujeres y las mujeres indígenas desde una visión decolonial y comunitaria. Aunque Bolivia ha generado políticas de inclusión y reivindicación de los derechos de las mujeres, en su proyecto internacional no hay programas específicos que incorporen un discurso despatriarcalizador. Se sostiene que la implementación de una política exterior sustentada en saberes, creencias y demandas de los pueblos indígenas andinos ha creado una ventana de oportunidad para integrar a grupos históricamente marginados. Se adoptó una metodología de investigación cualitativa, llevando a cabo tareas de recolección de información de diversas fuentes: entrevistas, revisión de documentación, noticias y bibliografía.