bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Effectiveness of a Personalized Home-Based Motor-Cognitive Training Program in Community-Dwelling Older Adults: Protocol for a Pragmatic Pilot Randomized Controlled Trial
Authors: Seinsche Julia , de Bruin Eling D , Saibene Enrico , Rizzo Francesco , Carpinella Ilaria , Ferrarin Maurizio , Ifanger Sarina , Moza Sotiria , Giannouli Eleftheria 
Published: September 2023

Background
Exergame-based motor-cognitive training in older adults has been associated with improvements in physical, cognitive, and psychological functioning. The novel Cocare system (Dividat GmbH), developed through a user-centered design process, allows motor-cognitive training in a telerehabilitation setting. It includes (1) a stationary stepping platform for supervised exergame training (Dividat Senso; Dividat GmbH), (2) a home-based version (Dividat Senso Flex, which is a rollable pressure-sensitive mat; Dividat GmbH), (3) an assessment system (including motor-cognitive tests), and (4) a rehabilitation cockpit for remote training supervision and management.

Objective
The aim of this study is to test the feasibility and effectiveness of this novel training system.

Methods
A total of 180 older adults from Switzerland, Italy, and Cyprus aged ≥60 years with a prescription for rehabilitation are randomly allocated to an intervention group or a control group. Both groups continue with their usual care, whereas participants in the intervention group additionally perform a 2-week supervised exergame training program at rehabilitation centers, followed by a 10-week home training program under remote supervision. The assessment system is used to indicate the start level of each participant, and, in both intervention periods, standardized progression rules are applied. The measures of feasibility include adherence, attrition, exergame enjoyment, willingness to perform such a training program, and the number and types of help requests. Effectiveness is assessed in terms of cognitive and physical functioning, balance confidence, and quality of life.

Results
Data collection started in February 2023 and is ongoing. Final measurements are expected to be performed in January 2024.

Conclusions
Owing to the user-centered design approach, the Cocare system is expected to be user-friendly and offers several novel features to cover the whole continuum of care. This pragmatic trial will provide valuable information regarding final necessary adaptations and subsequent implementation efforts.

Trial Registration
ClinicalTrials.gov NCT05751551; https://www.clinicaltrials.gov/study/NCT05751551

International Registered Report Identifier (IRRID)
DERR1-10.2196/49377
Pemetaan cepat batimetri perairan dangkal menggunakan citra Sentinel-2 dan Google Earth Engine di Perairan Tanjung Kelayang – Pulau Belitung
Authors: Munawaroh Munawaroh , Wicaksono Pramaditya , Rudiastuti AW 
Published: September 2023

Abstrak Peta batimetri perairan dangkal dapat membantu pengelolaan, pemantauan, dan perlindungan bagi ekosistem di dalamnya. Namun, ketersediaan peta batimetri di wilayah perairan dangkal di Indonesia masih terbatas. Untuk itu, diperlukan sebuah metode pemetaan cepat estimasi batimetri di perairan dangkal di Indonesia. Penelitian ini mencoba mengaplikasikan metode otomatisasi pemetaan batimetri perairan dangkal di Tanjung Kelayang menggunakan band biru dan hijau dari mosaik clean-coastal-water citra Sentinel-2, klorofil-a dari aqua-MODIS pada platform Google Earth Engine (GEE). Tujuan dari penelitian ini adalah menguji keandalan metode pemetaan cepat batimetri dengan menggunakan data mosaik citra satelit Sentinel-2, klorofil-a dan algoritma band-ratio pada platform GEE di wilayah penelitian. Hasil penelitian menunjukkan model SDB (Satellite Derived Bathymetry) memiliki R2 sebesar 0,62, mean absolute erorr (MAE) sebesar 1,77 meter dan RMSE sebesar 2,02 meter dengan estimasi nilai kedalaman optimum 5 meter dan maksimum 10 mter. Dengan demikian, model SDB yang dihasilkan dapat diandalkan sebagai alternatif untuk pemetaan cepat batimetri di perairan dangkal, meskipun harus berkompromi dengan akurasi peta batimetri yang dihasilkan. Abstract Bathymetric maps of shallow waters can aid in managing, monitoring, and protecting ecosystems within them. However, the availability of bathymetric maps for shallow water regions in Indonesia still needs to be improved. Therefore, a method of rapid mapping for bathymetry in shallow waters in Indonesia is needed. This study attempts to apply an automated method for mapping shallow water bathymetry in Tanjung Kelayang using the blue and green bands of the clean-coastal-water mosaic of Sentinel-2 images, chlorophyll-a data from aqua-MODIS, and the Google Earth Engine (GEE) platform. This research aims to test the reliability of the rapid bathymetry mapping method using Sentinel-2 image mosaics, chlorophyll-a data, and band-ratio algorithms on the GEE platform in the study area. The results of the study show that the Satellite Derived Bathymetry (SDB) model has an R2 value of 0,62, a mean absolute error (MAE) of 1,77 meters, and a root mean square error (RMSE) of 2,02 meters, with an estimated optimal depth value of 5 meters and a maximum depth value of 10 meters. Thus, the generated SDB model can be considered a reliable alternative for rapid bathymetry mapping in shallow waters, although it may compromise the accuracy of the resulting bathymetric maps.
Kesiapsiagaan masyarakat desa tangguh bencana terhadap ancaman tsunami di Kabupaten Cilacap
Authors: Akhirianto Novian Andri , Giyarsih Sri Rum , Mardiatno Djati 
Published: September 2023

Abstrak Wilayah pesisir Kabupaten Cilacap memiliki potensi ancaman tsunami yang dapat terjadi setiap saat, sehingga masyarakat yang tinggal di dalamnya dituntut memiliki kesiapsiagaan yang baik. Adanya intervensi program “Desa Tangguh Bencana” (Destana), tidak serta-merta menjamin kesiapsiagaan masyarakat selalu dalam kondisi baik. Penelitian ini bertujuan untuk mengkaji tingkat kesiapsiagaan masyarakat Destana tsunami, menggunakan empat parameter kesiapsiagaan masyarakat (pengetahuan risiko bencana, rencana tanggap darurat, sistem peringatan bencana, dan mobilisasi sumberdaya). Penelitian ini dilakukan dengan metode survei menggunakan kuesioner, terhadap 100 responden rumah tangga yang ada di 8 desa yang sudah ditetapkan menjadi Destana di Kabupaten Cilacap. Analisis data dilakukan dengan analisis indeks untuk mengetahui tingkat kesiapsiagaan masyarakat terhadap ancaman tsunami. Hasil penelitian menunjukkan tingkat kesiapsiagaan masyarakat Destana tsunami di Kabupaten Cilacap berada pada kategori hampir siap, dengan indeks kesiapsiagaan masyarakat 55. Adanya intervensi program Destana belum mampu menjadikan tingkat kesiapsiagaan masyarakat terhadap ancaman tsunami pada level siap ataupun sangat siap. Hal tersebut disebabkan karena keempat parameter kesiapsiagan belum optimal, dimana mobilisasi sumberdaya menjadi parameter yang paling belum optimal. Dukungan dari berbagai pihak sangat dibutuhkan untuk meningkatkan kesiapsiagaan masyarakat terhadap ancaman tsunami di Kabupaten Cilacap. Abstract The coastal area of Cilacap Regency has the potential for a tsunami hazard that can occur at any time, so that the community who live in it are required to have good preparedness. The program intervention of Disaster Resilient Village (Destana) does not necessarily guarantee that community preparedness is always in good condition. This research aims to assess the level of preparedness of the tsunami village community, using four parameters of community preparedness (disaster risk knowledge, emergency response plans, disaster warning systems, and resource mobilization). This research was conducted using a survey method using a questionnaire, to 100 household respondents in 8 villages that had been designated as the Destana. Data analysis was carried out using index analysis to determine the level of community preparedness against the threat of a tsunami. The results showed that the community preparedness level of the Destana tsunami was in the almost ready category, with a community preparedness index of 55. The four parameters of preparedness are not optimal, with resource mobilization being the least optimal parameter. Support from various parties is urgently needed to increase community preparedness against the tsunami hazard in Cilacap Regency.
Therapeutic evaluation of Benzimidazole antihelminthic combinations in the treatment of geohelminthiasis among infected children at the Moanda Medical Center in South-east, Gabon
Authors: Ndong Thiéry Mba , Sima Cédric Obiang , Nieguitsila Adelaïde , Nzamba Ulrick , Moudoumi Fael Kondji , Obame Louis Clément Engonga 
Published: September 2023

Background: Geohelminthiasis is a major public health problem in sub-Saharan Africa. To combat these infections, benzimidazole-based antihelmintics are used in most mass drug administration programs. This study evaluates the therapeutic efficacy of two forms of administration of benzimidazole-based antihelmintics to children with geohelminthiasis at the Moanda. Medical center
Materials and Methods: This retrospective, prospective and comparative study encompassed the periods from February 13, 2022 to September 28, 2022, enrolled children aged 2 to 17 years, diagnosed positive for the main geohelminths by microscopic techniques, at the medical analysis laboratory of the Moanda Medical Center.
Results: 198 children with geohelminthiasis were included in this study. Using the Wilcoxon signed ranks test with two-sided alternative continuity correction, the level of statistical significance retained was p ≤ 0.05, This study showed that, at control C1, twenty-one days after treatment, the cure rates of participants in group A, against Ascaris and Trichuris were 98% [86-100], 69% [56-79]] respectively, and those in group B, 96% [84-99], and 64% [51-75]. At the C2 control, 42 days after treatment, participants' cure rates were 89% [75-96] and 68% [69-85] respectively for group A, and 96% [84-99] and 68% [55-79] for group B. Irrespective of the combination therapy administered against species such as Strongyloides, hookworms and Oxyure (Enterobius vermicularus), the cure rate was 100% in both controls. Reduction in number of eggs and larvae of these species was also highly significant, at almost 100%, irrespective of group A or B, in both controls. Lowest reduction in number of eggs 45.05% [41.07-49.091], was observed among Trichuris trichiura, during control 2 in group B. The therapeutic combinations administered were satisfactory and well tolerated by the participants in all the regimens implemented, except for Trichuris trichiura where resistance was observed, in participants treated with combination B. The therapeutic combinations administered were satisfactory and well tolerated by the participants, in all the regimens implemented, with the exception of Trichuris trichiura, which showed resistance in participants treated with combination B.
Conclusion: These Benzimidazole-based antihelmintic drugs showed satisfactory efficacy against geohelminthiasis. However, if this scourge is to be eradicated, Trichuris treatment needs to be improved
Formulation and Evaluation of Gastroretentive Floating Microspheres of TRAMADOL HCl
Authors: Zodage Kishan , Gurav Lokesh , Ravandale Sandip , Jadhav Harshali 
Published: September 2023

This study presents the formulation and evaluation of sustained-release microspheres containing Tramadol HCl. The aim was to achieve prolonged drug release for enhanced therapeutic efficacy and improved patient compliance. The microspheres were prepared using a solvent evaporation method with various combinations of polymers Agar and Pectin. The physical appearance, particle size, drug content, and moisture content were assessed for stability over time. Among the formulations, Batch F7 emerged as a standout candidate, displaying excellent buoyancy and sustained drug release characteristics. Comprehensive evaluations included in vitro drug release studies, kinetic data analysis, and stability assessments over 90 days. The study concludes that the combination of Agar and Pectin polymers in Batch F7 holds significant promise for achieving controlled drug release, suggesting its potential for advanced drug delivery systems.
Keywords: Gastroretentive Floating Microspheres, Tramadol HCl, prolonged drug release, patient compliance
Roles of Herbals in Paracetamol Induced Hepatotoxicty
Authors: Devi Monika , Verma Kapil Kumar , Kumar Inder 
Published: September 2023

In the area of herbal medicine, this has led to a great deal of research and development. In the majority of industrialized and developing nations today, there is a rising need for herbal medicine. The most common form of liver disease varies by country and may be impacted by local factors. Infection with viruses and exposure to specific chemicals are two causes of liver diseases. Herbal medications have the potential to be an effective treatment for liver problems. An extensive review of the literature on hepatoprotective plants clearly shows that herbal medications have significant promise for the treatment of liver ailments. It is difficult to find effective treatments for common liver conditions such as cirrhosis, fatty liver, and chronic hepatitis. There aren't many therapeutic drugs that work well and rarely cause side effects. Few plants can effectively treat liver disorders, so there is a lot of interest in researching the many plant therapies that can help with liver diseases. As a result, we conclude that herbs are an important source of hepatoprotective and liver regeneration drugs. More study is needed, however, to identify, characterize, and standardize the active substances, beneficial compounds, and formulations for the treatment of liver illnesses. The availability of modern hepatoprotective medications with realistic clinical utility is still quite restricted, and the discovery of new compounds with similar potentials will undoubtedly encourage the drug discovery process.
Keywords: Herbal Medicine, Hepatotoxicity, Hepatoprotective, Antioxidant Activities
Simultaneous Estimation of Pregabalin and Etoricoxib in Bulk and Pharmaceutical Dosage Form by Using RP-HPLC Method
Authors: Hanumanth Vislavath , Ravi Kumar P , Sravya Kaleru , Padmavathi Yenumula , Raghavendra Babu Nayaka , Sowmya Koppera 
Published: September 2023

A simple, accurate, precise method was developed for the simultaneous estimation of the Pregabalin and Etoricoxib in bulk and Pharmaceutical dosage form. Chromatogram was run through Ascentis (C18 150 x 4.8 mm, 2.8m). Mobile phase containing Buffer 0.01N Methanol: Na2HPO4 (0.1%OPA is added to adjust pH 5.4) taken in the ratio 70:30 was pumped through column at a flow rate of 1ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was 235nm. Retention time of Pregabalin and Etoricoxib were found to be 2.396 minutes and 2.968 minutes. %RSD of the Pregabalin and Etoricoxib were found to be 1.0 and 1.1 respectively. %Recovery was obtained as 99.82% and 99.99% for Pregabalin and Etoricoxib respectively. LOD, LOQ values obtained from regression equations of Pregabalin and Etoricoxib were 0.27, 0.81 and 0.18, 0.55 respectively. Regression equation of Pregabalin is y=3501.2x+839.82, and y=3696.3x+1383.5 for Etoricoxib. Retention time and run time was decreased, so the method was developed simple and economical that can be adopted in regular Quality control test.
Keywords: Pregabalin, Etoricoxib, RP-HPLC, Method validation
Spirulina platensis improves insulin sensitivity and reduces hyperglycemia-mediated oxidative stress in fructose-fed rats
Authors: Kougblenou Kounouho R. Adounkpe , Kantati Yendubé T. , Dossou-Yovo Komlan M. , Lawson-Evi Povi , Eklu-Gadegbeku Kwashie 
Published: September 2023

Oxidative stress, hyperglycemia and insulin resistance are hallmarks of diabetes mellitus. The present study aimed to assess the antidiabetic activity of a local strain of Spirulina platensis produced at Pahou (Benin), known as “Spiruline Dou Bogan” (SPD), in fructose-fed rats. Glucose metabolism impairment was induced by feeding 8g/kg, body weight (bw), fructose solution orally to Sprague Dawley rats (n = 8) for 56 days, treated with SPD (18.75; 37.5 and 75 mg/kg, bw), and analyzed for plasma blood glucose, serum biochemistry and the markers of oxidative stress (Ferric Reducing Antioxidant Power Assay (FRAP), Malondialdehyde (MDA), Reduced glutathione (GSH), DPPH radical scavenging assay. SPD concentrations, given orally for 42 days, significantly reversed the elevations in plasma blood glucose, MDA, and the reduction in kidneys glutathione activity. Oral administration of 18.75, 37.5, and 75 mg/kg doses of SPD also lowered serum Aspartate Aminotransferase (ASAT), Alanine Aminotransferase (ALAT), Triglycerides and Creatinine levels. SPD 75 mg/kg treatment in particular has significantly decreased serum Triglycerides level and increased HDL-Cholesterol levels, reversing the atherogenic potential of 56 days fructose administration. The consumption of S. platensis produced locally in Benin as a food supplement, easily accessible for low-income populations, may be helpful in the prevention and management of type 2 diabetes.
Keywords: Oxidative stress; Spirulina platensis; hyperglycemia; insulin resistance, fructose diet
Methanolic and ethanolic phytochemical screening of Sweet flag (Acorus calamus L.) rhizome
Authors: Sharma Leihaothabam Dinendra , Khan Md Riyajuddin , Devi Angom Kikim 
Published: September 2023

Acorus calamus is a medicinal plant with several ethno-medicinal properties. The present study was carried to screen the presence of major phytochemical groups. Phytochemical screening of methanolic and ethanolic rhizome extract showed the presence of carbohydrates, alkaloids, phenolic compound, protein, amino acid flavanoids and tannins. The total phenolic content in methanolic and ethanolic rhizome extracts in terms of gallic acid equivalent was 4.77.50 and 7.5 mg/g of extract powder respectively whereas the total flavonoid content of methanolic and ethanolic extract was 12.02 and 12.89 mg QE/g of extract respectively. Total antioxidant activity was found highest in ethanol extract (75.6 µg AAE/mg of extract) than methanol extract (37.2 µg AAE/mg of extract). Reducing power is also found highest in ethanol extract than methanol extract.
Keywords: Acorus calamus, phytochemical screening, methanol, ethanol.
Supermarket Transaction Records In Dietary Evaluation – the STRIDE validation study.
Authors: Jenneson Victoria , Greenwood Darren , Clarke Graham , Rains Timothy , Shute Becky , Morris Michelle 
Published: September 2023

Introduction & BackgroundSupermarket transactions leave a digital footprint which offers insight into dietary habits. Use of transactions in nutrition research has increased, but these data are rarely validated. The STRIDE (Supermarket Transaction Records In Dietary Evaluation) study compares dietary estimates from supermarket transactions with self-reported intake from an online Food Frequency Questionnaire (FFQ).
Objectives & ApproachWorking with a large UK supermarket, loyalty card customers were recruited to one of four waves (accounting for seasonal dietary variation). Participants completed an online FFQ and consented to sharing their transaction records for one year during the study, and one year prior. The Bland-Altman method was used to calculate agreement and limits of agreement between transactions and intake for daily energy, sugar, total fat, saturated fat, protein and sodium (absolute and energy-adjusted).
Relevance to Digital FootprintsSupermarket transactions are a form of digital footprints data with advantages over survey methods, with regards scalability and objectivity, for monitoring population-level diets.
Results1,788 participants from four UK regions gave consent. 686 participants who completed the FFQ and made purchases during the same period, were included for analysis. Participants were mostly female (72%), with a mean age of 56 years (SD 13). A regression equation for agreement is presented for estimating intake from purchases. Agreement for absolute measures was poor overall, but higher for single-person households and households reporting a higher proportion of total food purchases from the study retailer. Agreement was stronger for energy-adjusted nutrient estimates, particularly fat, with purchase records under-estimating the proportion of total energy intake from fat by just 2%.
Conclusions & ImplicationsThe STRIDE study found that household purchases from a single retailer were a poor proxy for individual-level nutrient intakes. However, close agreement on average energy-adjusted estimates suggests purchases are a good indicator of dietary composition. Supermarket transactions have utility for population dietary assessment, ecological studies, and identifying intervention targets based on dietary patterns. Digital footprint data from transactions can contribute to the design and monitoring of national and local-level interventions.
Healthy foods, healthy sales? Cross-category spillover effects of a reward program promoting sales of fruit and vegetables
Authors: Panzone Luca , Tocco Barbara , Brecic Ruzica , Gorton Matthew 
Published: September 2023

Introduction & BackgroundGlobally, consumption of Fruit and Vegetables (F&V) remains below nutritional guidelines. Marketing healthy products can be complex for retailers, and a key challenge is the design of strategies that benefit retailers, e.g., through improved loyalty, and deliver progress on societal goals.
Objectives & ApproachThis study evaluates a point-plus-cash frequency reward program where participants received points by purchasing selected F&V, redeemable against a reward (plush toys in the shape of F&V). We estimate the impact of the program using a difference-in-difference-in-difference model, which compares expenditures in several categories before, during, and after the promotional period, across two different years, and separately for consumers who redeemed a reward and those who did not. Identification includes weighting for the propensity scores, and using an instrumental variable approach.
Relevance to Digital FootprintsThe data refers to grocery expenditure in five categories in the focal retailer for over 268,000 consumers, over 27 weeks for 2 years, as recorded through their loyalty card.
ResultsThe reward program significantly increased expenditures in F&V in the focal retailer during the promotional period. However, results differed depending on reward redemption. For reward-redeemers, the program increased expenditures in F&V as well as in other food categories, an effect that persisted – at a declining rate – after the program stopped. The program had a short-lived effect on non-rewards redeemers, who only increased F&V expenditures during the promotional period.
Conclusions & ImplicationsResults indicate that a loyalty program promoting sales of F&V can create win-win benefits to both society and the retailer: it increases expenditures on healthy foods (F&V), while improving overall loyalty (i.e., expenditures) to the retailer.