bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival prediction of hepatocellular carcinoma by measuring the extracellular volume fraction with single-phase contrast-enhanced dual-energy CT imaging
Authors: Chen Yan , Shi Kexin , Li Zhen , Wang Huixia , Liu Nana , Zhan Pengchao , Liu Xing , Shang Bo , Hou Ping , Gao Jianbo , Lyu Peijie 
Published: July 2023

PurposeThis study aimed to investigate the value of quantified extracellular volume fraction (fECV) derived from dual-energy CT (DECT) for predicting the survival outcomes of patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).Materials and methodsA total of 63 patients with HCC who underwent DECT before treatment were retrospectively included. Virtual monochromatic images (VMI) (70 keV) and iodine density images (IDI) during the equilibrium phase (EP) were generated. The tumor VMI-fECV and IDI-fECV were measured and calculated on the whole tumor (Whole) and maximum enhancement of the tumor (Maximum), respectively. Univariate and multivariate Cox models were used to evaluate the effects of clinical and imaging predictors on overall survival (OS) and progression-free survival (PFS).ResultsThe correlation between tumor VMI-fECV and IDI-fECV was strong (both p&lt; 0.001). The Bland–Altman plot between VMI-fECV and IDI-fECV showed a bias of 5.16% for the Whole and 6.89% for the Maximum modalities, respectively. Increasing tumor VMI-fECV and IDI-fECV were positively related to the effects on OS and PFS (both p&lt; 0.05). The tumor IDI-fECV-Maximum was the only congruent independent predictor in patients with HCC after TACE in the multivariate analysis on OS (p = 0.000) and PFS (p = 0.028). Patients with higher IDI-fECV-Maximum values had better survival rates above the optimal cutoff values, which were 35.42% for OS and 29.37% for PFS.ConclusionThe quantified fECV determined by the equilibrium-phase contrast-enhanced DECT can potentially predict the survival outcomes of patients with HCC following TACE treatment.
Differential diagnostic value of tumor markers and contrast-enhanced computed tomography in gastric hepatoid adenocarcinoma and gastric adenocarcinoma
Authors: Dong Congsong , Wang Yanling , Gu Xiaoyu , Lv Xiaojing , Ren Shuai , Wang Zhongqiu , Dai Zhenyu 
Published: July 2023

ObjectiveThis study aimed to investigate the effectiveness of tumor markers and contrast-enhanced computed tomography (CE-CT) in differentiating gastric hepatoid adenocarcinoma (GHA) from gastric adenocarcinoma (GA).MethodsThis retrospective study included 160 patients (44 with GHA vs. 116 with GA) who underwent preoperative CE-CT. Preoperative serum concentrations of tumor biomarkers and CT imaging features were analyzed, including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), tumor location, growth pattern, size, enhancement pattern, cystic changes, and mass contrast enhancement. Multivariate logistic regression analyses were performed to evaluate useful tumor markers and CT imaging features for differentiating GHA from GA.ResultsWhen compared to GA, GHA showed a higher serum AFP [13.27 ng/ml (5.2–340.1) vs. 2.7 ng/ml (2.2–3.98), P &lt;0.001] and CEA levels [4.07 ng/ml (2.73–12.53) vs. 2.42 ng/ml (1.38–4.31), P &lt;0.001]. CT imaging showed GHA with a higher frequency of tumor location in the gastric antrum (P &lt;0.001). GHA had significantly lower attenuation values at the portal venous phase [PCA, (82.34 HU ± 8.46 vs. 91.02 HU ± 10.62, P &lt;0.001)] and delayed phase [DCA, (72.89 HU ± 8.83 vs. 78.27 HU ± 9.51, P &lt;0.001)] when compared with GA. Multivariate logistic regression analyses revealed that tumor location, PCA, and serum AFP level were independent predictors of differentiation between GHA and GA. The combination of these three predictors performed well in discriminating GHA from GA, with an AUC of 0.903, a sensitivity of 86.36%, and a specificity of 81.90%.ConclusionsIntegrated evaluation of tumor markers and CT features, including tumor location, PCA, and serum AFP, allowed for more accurate differentiation of GHA from GA.
Surfaces Family with Bertrand Curves as Common Asymptotic Curves in Euclidean 3–Space E3
Authors: Aldossary Maryam T. , Abdel-Baky Rashad A. 
Published: July 2023

The main result of this paper is constructing a surfaces family with the similarity of Bertrand curves in Euclidean 3–space E3. Then, by utilizing the Serret–Frenet frame, we conclude the sufficient and necessary conditions of surfaces family interpolating Bertrand curves as common asymptotic curves. Consequently, the expansion to the ruled surfaces family is also depicted. As implementations of our main results, we demonstrate some examples to confirm the method.
An AN ANALYSIS OF IDIOMS IN THE SPONGEBOB SQUAREPANTS CARTOONS
Authors: Muhammad Dwiky Rizaldy  
Published: July 2023

Abstract
This study was conducted to determine whether SpongeBob SquarePants Cartoons contains idioms, as there are some challenges in understanding and comprehending these idioms. A qualitative technique is used in this investigation. In this study, all utterances including or explaining idioms in SpongeBob SquarePants cartoons were used as primary data. The cartoon was evaluated by the researcher utilizing Seidl and McMordie's idioms theory (1988). According to the study's findings, there are two types of idioms, namely verb + preposition and verb + all types of words. The researcher found 6 data which are detailed as follows: for verb + preposition appeared 5 times and verb + all types of words was 1 times.
Keywords: Idioms, Spongebob Squarepants Cartoons
Landslide Assessment and Hazard Zonation in the Birbir Mariam District, Gamo Highlands, Rift Valley Escarpment, Ethiopia
Authors: Oyda Yonas , Regasa Hailu 
Published: July 2023

The current research focused on landslide assessment and hazard zonation in the Birbir Mariam district of the Gamo highlands. The study examined landslide causative factors and used the slope susceptibility evaluation parameter to create a landslide hazard zonation covering an area of 110 km2. The landslide hazard zonation was classified using facet-wise observation. As a result, the intrinsic and external causal parameters of score schemes have been held responsible for slope instability. Inherent causative elements consist of slope geometry, slope material (rock/soil), structural discontinuities, land use/land cover, and groundwater conditions. Rainfall and human interest have seemed as external elements. The intrinsic and external triggering elements for every facet (a total of 106) were rated for their contribution to slope instability. Finally, an evaluated landslide hazard value was calculated and classified into three landslide hazard classes. According to the findings, the area has a high hazard zone of 18.87% (20.76 km2), a moderate hazard zone of 54.72% (60.19 km2), and a low hazard zone of 26.41% (29.05 km2).
I2‐DMSO‐Mediated Cascade Cyclization of β‐Ketosulfoxonium Ylides and β‐Enaminones: Synthesis of Quaternary‐Carbon‐Centered 2‐Hydroxy‐pyrrol‐3(2H)‐ones
Authors: Kumar Saini Rahul , Borpatra Paran J. , Kumar Pandey Satyendra 
Published: July 2023

AbstractA novel I2‐DMSO‐mediated cascade cyclization approach for synthesizing 2‐hydroxy‐pyrrol‐3(2H)‐one scaffold from readily accessible β‐ketosulfoxonium ylides and β‐enaminone derivatives has been developed. Under metal‐free and mild conditions, this cascade transformation facilitates the formation of one C−C bond and one C−N bond in a single reaction vessel, exhibiting a wide range of functional group compatibility. In addition, this method added an active hydroxyl group to a quaternary carbon center.
Expanding a laboratory model for evaluating relapse of caregiver nonadherence
Authors: Williams Catherine L. , Montague Kyleigh L. , Bernstein Alec M. , Call Nathan A. , Slocum Sarah K. 
Published: July 2023

AbstractCaregiver adherence to treatment plans is likely maintained by negative reinforcement and can contact extinction when child responding relapses. When caregiver adherence contacts extinction, caregiver nonadherence, such as reinforcing their child's challenging behavior, relapses, threatening treatment efficacy. Previous laboratory models demonstrating the relapse of caregiver nonadherence only evaluated treatment for behavior maintained by social‐positive reinforcement, not that maintained by social‐negative reinforcement. These models only measured caregiver nonadherence as discrete events, which cannot capture the magnitude of each error. The present study was an evaluation of the relapse of caregiver nonadherence during simulated treatments for escape‐maintained challenging behavior. First, caregivers placed demands in a home‐like setting and a research confederate responded to these demands in a manner mimicking clinical clients. Next, caregivers were taught to implement treatment in a clinical setting and the confederate's behavior gradually improved. Last, caregivers returned to the home‐like setting and confederate challenging behavior relapsed. Nonadherence relapsed for all caregivers, demonstrating the need for additional research on methods for mitigating caregiver relapse during treatment of children's challenging behavior and the usefulness of the proposed measurement system for future research.
Superconvergence analysis of the bilinear‐constant scheme for two‐dimensional incompressible convective Brinkman–Forchheimer equations
Authors: Yang Huaijun , Jia Xu 
Published: July 2023

AbstractIn this article, a low order conforming mixed finite element method is proposed and investigated for two‐dimensional convective Brinkman–Forchheimer equations. Based on the special properties of the bilinear‐constant finite element pair on the rectangular mesh and the careful treatment of the nonlinear terms, the superclose error estimates for velocity in ‐norm and pressure in ‐norm are obtained. Then, in terms of interpolation post‐processing technique, the global superconvergence results are derived. Finally, some numerical experiments are carried out to demonstrate the correctness of the theoretical findings.
Public Service Resilience in a Post-COVID-19 World: Digital Transformation in Nordic Higher Education
Authors: Asante Michael Oduro , Liyanapathiranage Sudeepika Wajirakumari Samarathunga , Pinheiro Rómulo 
Published: July 2023

AbstractThis chapter draws on seminal contributions from the crisis management and resilience literature to develop and test a new framework for organisational resilience in higher education in the context of digital transformation. The study unpacks developments before and during the COVID-19 crisis and sheds light on crucial endogenous and exogenous factors likely to determine resilience outcomes. It does so by developing and testing a novel analytical framework centred on resilient antecedents, processes and outcomes. The empirical findings suggest that, in the Nordic countries, higher education institutions denote a high ability to adapt to new situations whilst retaining both function and identity, that is, they are resilient. We identify and unpack a number of key resilient drivers and reflect on the implications for research and practice going forward.
Challenges, Opportunities, and Coping Strategies When Faced with the COVID-19 Pandemic: A Qualitative Study of Academics in Mainland China and Hong Kong
Authors: Liu Yingxin , Horta Hugo 
Published: July 2023

AbstractThis chapter explores the responses of academics in mainland China and Hong Kong amid the COVID-19 outbreak. Using semi-structured interviews with 33 academics (17 in mainland China and 16 in Hong Kong), we find varying responses to the unprecedented COVID-19 pandemic. Academics in mainland China and Hong Kong had varied stances about the impact of the pandemic on their academic life, both positive and negative. The chapter identifies the major challenges and opportunities perceived by academics, and their coping strategies when faced with disruptive conditions. The chapter demonstrates the adaptiveness of academics during the COVID-19 pandemic, even though resilience of academics differs between individuals.
Post-COVID-19: Renegotiating the Scope, Role, and Function of Support and Development for Students in Higher Education Across the Globe
Authors: Schreiber Birgit , Luescher Thierry , Perozzi Brett , Moscaritolo Lisa Bardill 
Published: July 2023

AbstractThe COVID-19 pandemic has shed a glaring light on the range of obstacles to equitable learning and development in higher education across the globe. Higher education and Student Affairs and Services (SAS), as part of higher education, are faced with a set of challenges that are in part related to the characteristics of their student bodies, the resourcing of the institutions, and also the sociocultural and political contexts in which the institutions and the students are embedded. In this study, four researchers from different parts of the world explore how SAS has responded to the changes in student and institutional needs and responses due to COVID-19. To this end, we surveyed 781 SAS professionals from across the globe. Overall, the data show SAS changed its critical role in mediating the various challenges related to COVID-19 within and beyond the higher education institutions that impact student success.In the course of the analysis of our data, there emerged four domains that impact student success in the context of the pandemic. They include (1) the students’ personal situation; (2) the sociocultural context and familial milieu in which the student is embedded; (3) the institutional and academic domain; and (4) the broader, macro-public domain, which includes larger structural and political-economic conditions. Based on the data, we developed a heuristic model that aids in understanding SAS’ engagement with students’ ability to learn and develop in higher education under the unique conditions presented by the COVID-19 pandemic. The data show that the four domains have varying significance in different world regions and national systems of higher education, depending on political, economic, and sociocultural contexts. Additionally, while SAS and universities do a great deal to support students in their learning, factors in the macro-public domain and factors in the sociocultural community and familial milieu are mitigated by SAS to promote a context that is conducive to learning across the globe.Finally, the study demonstrated that COVID-19 has changed not only the scope of SAS but also its role in lobbying and advocating for living and learning contexts that are more conducive to student success. This is an expanding role and function of SAS and appears to emerge as a critical factor for SAS to become more impactful in supporting conditions for student success. The chapter concludes with recommendations to further develop this heuristic model to contribute to the development of a global SAS profession that plays a significant role in advancing higher education practices that promote equitable success for all students.
Obesity Intervention in Sub-Saharan Africa: A systematic review protocol
Authors: Agyemang Kingsley , Anokye Nana 
Published: July 2023

AbstractIntroductionThe increasing prevalence of obesity in Sub-Saharan Africa (SSA) has made it a pressing public health issue that requires effective interventions tailored to the region’s unique challenges. This protocol outlines a systematic review approach that aims to examine the existing evidence on obesity interventions in SSA, focusing on their effectiveness, implementation strategies, and potential barriers.Methods and analysisTo identify relevant studies in Sub-Saharan Africa (SSA), MEDLINE (PubMed), MEDLINE (EBSCOHost), Scopus, Web of Science, PsycINFO, Cochrane and EMBASE databases will be searched during the review. Studies on obesity interventions in SSA will be considered for inclusion criteria, encompassing various intervention types, target populations, and study designs. Abstracts and titles will be independently assessed by two reviewers, who are aware of the author and journal information. A third reviewer will be consulted for cases where agreement was not reached or when clarity will be needed. The methodological quality of the included research will be assessed using the “Effective Public Health Practise Project quality assessment tool for quantitative studies. For data synthesis and reporting, two independent reviewers will assign effect scores to each intervention’s outcome category (dietary behaviour, physical activity, or anthropometric outcomes) through a duplicate scoring exercise.Ethics and disseminationSince no original data will be collected as part of this review, ethical approval is not required. The completed review will be submitted for publication in a peer-reviewed journal and presented at conferences.PROSPERO registration numberCRD42023430503
The influence of marker number and sequencing depth on the ability to identify mismatch repair deficient tumours
Authors: Law Joseph , Gallon Richard , Teare Ethan , Koref Ivan Santibanez , Phelps Rachel , Burn John , Jackson Michael , Koref Mauro Santibanez 
Published: July 2023

1.AbstractAnalysis of somatic mutation patterns is widely used to infer exposure to exogenous and endogenous mutagenic influences. This raises the question of the amount of sequence data required to detect factors of interest. A common use of mutation pattern analysis is the identification of increased microsatellite instability to uncover mismatch repair (MMR) defects in tumours and normal tissues. Here we explore the effects of sequencing depth and the number of loci analysed on the ability to detect MMR deficiency using artificial neural networks and publicly available amplicon sequencing data from colorectal tumours on 24 short quasi monomorphic microsatellites (up to 12 bp in length, PMID 31471937) split in a training (99 samples) and a test set (95 samples). We show that, at a sequencing depth of 200, pairs mononucleotide repeats can achieve discrimination between MMR proficient and deficient colorectal tumours similar to that obtained with the full 24 marker panel, with accuracies above 97% and ROC AUCs in excess of 99% in the test set. Our results indicate that for short monomorphic microsatellites considering the length distribution of the different alleles at each locus, representing these distributions as two-dimensional structures and including convolutional layers in the network can facilitate discrimination between MMR deficient and proficient tumour material. They also indicate that, despite the limitations imposed by amplification, sequencing accuracy and the limited divergence time between the sequences from one locus, high depth sequencing can be used to identify MMR deficiency from a limited number of loci. However, they also suggest that, for a fixed total number of reads per sample, increasing sensitivity by increasing the number of targets is more efficient than by increasing per target sequencing depth. These results are of interest for screening large numbers of samples and for assessing the impact MMR deficiency in different areas of the genome.
Guest editorial: challenging the coloniality of raced markets
Authors: Shabbir Haseeb , Hyman Michael R. , Kostyk Alena 
Published: July 2023

Purpose
This special issue explores how marketing thought and practice have contributed to systemic racism but could alleviate racially insensitive and biased practices. An introductory historical overview briefly discusses coloniality, capitalism, eugenics, modernism, transhumanism, neo-liberalism, and liquid racism. Then, the special issue articles on colonial-based commodity racism, racial beauty imagery, implicit racial bias, linguistic racism and racial imagery in ads are introduced.

Design/methodology/approach
The historical introduction is grounded in a review of relevant literature.

Findings
Anti-racism efforts must tackle the intersection between neo-liberalism and racial injustice, the “raceless state” myth should be re-addressed, and cultural pedagogy’s role in normalizing racism should be investigated.

Practical implications
To stop perpetuating raced markets, educators should mainstream anti-racism and marketing. Commodity racism provides a historical and contemporary window into university-taught marketing skills.

Social implications
Anti-racism efforts must recognize neo-liberalism’s pervasive role in normalizing raced markets and reject conventional wisdom about a raceless cultural pedagogy, especially with the emergence of platform economies.

Originality/value
Little previous research has tackled the history of commodity racism, white privilege, white ideology, and instituting teaching practices sensitive to minority group experiences.
A systematic review of Mendelian randomization studies on multiple sclerosis
Authors: Fazia Teresa , Baldrighi Giulia Nicole , Nova Andrea , Bernardinelli Luisa 
Published: July 2023

AbstractMendelian randomization (MR) is a powerful approach for assessing the causal effect of putative risk factors on an outcome, using genetic variants as instrumental variables. The methodology and application developed in the framework of MR have been dramatically improved, taking advantage of the many public genome‐wide association study (GWAS) data. The availability of summary‐level data allowed to perform numerous MR studies especially for complex diseases, pinpointing modifiable exposures causally related to increased or decreased disease risk. Multiple sclerosis (MS) is a complex multifactorial disease whose aetiology involves both genetic and non‐genetic risk factors and their interplay. Previous observational studies have revealed associations between candidate modifiable exposures and MS risk; although being prone to confounding, and reverse causation, these studies were unable to draw causal conclusions. MR analysis addresses the limitations of observational studies and allows to establish reliable and accurate causal conclusions. Here, we systematically reviewed the studies evaluating the causal effect, through MR, of genetic and non‐genetic exposures on MS risk. Among 107 papers found, only 42 were eligible for final evaluation and qualitative synthesis. We found that, above all, low vitamin D levels and high adult body mass index (BMI) appear to be uncontested risk factors for increased MS risk.