bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Ambient Air Mercury Levels in The Mercury Laboratory and Metrology Centre for Environmental Quality Instrumentation Standardization
Authors: Nurjaya  , Ardiansyah W , Syofyan Y 
Published: June 2023

Abstract
Today the use of heavy metals can be found in almost all aspects of life. However, the use of heavy metals causes a process of bioaccumulation of toxins from heavy metals into the body. One type of heavy metal that is very toxic is Mercury (Hg). According to the list of hazardous substances published by the Agency for Toxic Substances and Disease Registry (ATSDR), mercury occupies the third position among 275 substances harmful to human health. The mercury and metrology laboratory is a laboratory that functions to test mercury levels in both water, soil and air matrix samples. In carrying out a test or measurement of Mercury levels, employees at the Mercury and Metrology Laboratory of Centre for Environmental Quality Instrumentation Standardization (PSIKLH) always use Mercury in the process, so there is a possibility that the air in the Mercury and Metrology laboratory of PSIKLH is contaminated with Mercury because of the activities in it. That is the reason of researchers to test mercury levels in the ambient air around the Mercury laboratory and Metrology PSIKLH. This study aims to determine the level of mercury in the ambient air around the mercury and metrology laboratory of PSIKLH. The method used in this study is a quantitative analysis method using the Mercury Analyzer WA-5F from Nippon Instruments Corporation (NIC) which includes curve making, sampling, and measuring mercury levels in the sample. This research was conducted at the Mercury and Metrology Laboratory of PSIKLH. Based on research that was conduct, it shows that the highest concentration of mercury in the ambient air around the PSIKLH Mercury and Metrology Laboratory is found in the Atomic Absorption Spectrophotometer (AAS) room, the sampling equipment room, and the Hg tool room. Mercury levels contained in the three rooms were more than 0.01 mg/m3. However, mercury levels in the Mercury and Metrology Laboratory are still classified as normal because they have not passed the threshold of 0.05 mg/m3.
Factor and Barrier Implementing Building Information Modelling (BIM) in Green Construction in Indonesia
Authors: Susanti Riza , Fauziyah Shifa , Aziz Sheva Alviano 
Published: June 2023

Abstract
Building Information Modelling (BIM) is a technology that potential to increase effectiveness and productivity in projects. Implementing BIM in the project not only can simultaneously represent the physical modelling of a building but also can reduce waste and optimize time and resources as the aims of green construction. Nevertheless, unfortunately the level of BIM adoption in Indonesia is lower than other developing countries. The aim of this research is to analyse factors and barriers to implementing BIM to support green construction in Indonesia. This study uses a quantitative research method in a questionnaire survey of 20 construction projects in Indonesia to determine the factors driving BIM adoption and barrier to BIM adoption on construction projects in Indonesia. The result finds five factors driving the implementation of BIM in Indonesia i.e requirements from the government, BIM is believed to improve performance, BIM is believed better than existing method, technology and resources readiness, and support from top management. Despite the driving factors, the implementation of BIM also has barriers i.e lack of information, lack of BIM training for workers, reluctance to change, lack of owner requirement, and high the initial cost.
Analysis of the effect of motorcycle parking attendants on parking space unit Case Study : Poncol Station and Tawang Station
Authors: Narendra A , Widyadi M I 
Published: June 2023

Abstract
The movement or activities that take place in an area will undoubtedly be impacted by how developed it is. The city of Semarang experiences the same thing. With such high mobility, transportation modalities and related services are necessary. In Semarang City, there are two train stations: Tawang Station and Poncol Station. The purpose of this study is to measure the effect of motorcycle parking attendants on station parking spaces. The measurement is based on descriptive statistics on parking space unit’s width. Tawang Station has parking attendants, and Poncol Station does not. A primary survey was conducted at the Poncol and Tawang station. The survey calculating the number of active cars and the area utilised during peak, early, and late hours. Google Maps were used to predict peak hour. The presence of parking attendants shows 120% more effective than without parking attendants. Moreover on averagethe width, and degree of saturation are 106% and 110% respectively better than standard.
Adaptive Cruise Control tuned by Genetic Algorithm for Safe Distance of Automated Vehicle
Authors: Prastiyanto D , Apriaskar E , Ibrahim R F , Rumanda A , Manaf A A , Amelia I 
Published: June 2023

Abstract
The importance of safety in transportation has forced developments in automated vehicles. Many control methods have been introduced to ensure safe distance between automated vehicle and another car. This article presents an adaptive cruise control whose parameters are tuned by genetic algorithm for the case study of safe distance in automated vehicle. Two genetic algorithms with two different objective functions, i.e., integral square error (ISE) and integral absolute error (IAE), were evaluated. The results show that genetic algorithms could work well using both functions indicated by the obtained best fitness values through generations. The optimal controller parameter obtained by them also seems to be similar each other, including the distance, velocity and acceleration response of the automated vehicle. It is only the standard deviation that differs them. After 20 running tests, IAE produced 0.0288, 0.0439, and 0.0134 in standard deviation for verr_gain, xerr_gain, vx_gain, respectively, while ISE got 0.0169, 0.0755, and 0.0101. From the total values of standard deviation, we can conclude that GA with IAE performs slightly better since it has smaller value indicating that it has better repeatability.
Evaluation of Soil Liquefaction Using SPT Data at Boyolali Regency, Central Java
Authors: Askaviolita  , Ismanti Sito , Fathani Teuku Faisal 
Published: June 2023

Abstract
On 27 May 2006 at 05:54 local time, a major earthquake with a moment magnitude (Mw) of 6.3 occurred in Yogyakarta Province. This earthquake was widespread causing several damages in Yogyakarta Province and Central Java Province. One of the regencies in Central Java Province impacted was Boyolali Regency. This research aims to evaluate soil liquefaction based on the Standard Penetration Tests (SPT) in Boyolali Regency. Evaluation of soil liquefaction was necessary to minimize the damage as a preliminary in determining mitigation methods that can be applied. Besides Mw 6.3 earthquakes, according to SPT Data, several factors that triggered liquefaction were found in this study area such as a shallow groundwater table and the existence of a poorly graded sandy soil layer. The liquefaction was evaluated by comparing the Liquefaction Severity Index (LSI) and the Liquefaction Risk Index (LRI) using the simplified method. Based on the analysis, the result showed that Boyolali Regency had a value of LSI in the range of very low until low severity and a value of LRI in the range of low until the high risk.
Identifying Growth Pattern as Regional Classification in Central Java and Yogyakarta
Authors: Rahadini A 
Published: June 2023

Abstract
This study is the preliminary research of spatial inequality in Central Java. The regional differences are substantively irrepressible. The perception of north-south regions of Java exists and persist. As many of north regions have specialized in non-agriculture, the northern had been assumed as dynamic regions. This assumption has led to the differentiation of regional policy focused on north-south unbalance development. This study aims to evaluate the spatial pattern of Central Java and Yogyakarta based on economic growth from 1990-2010. The pattern indicates the relation of urban and its surrounding and no longer the contest of north and south region. Some current facts define that spread effects from the prime regions is beneficial for its surroundings. In this study, Semarang, Solo, and Yogyakarta, has been identified as the predominant cities toward their surroundings creating a cluster of growth pattern. The nearby surroundings obtain economic growth spill-over from those cities. On the other side, the regions locate away from prime cities have experienced lower growth. Consequently, the spatial inequality may occur across the regions.
Effects of Eudrilus eugeniae Worms and Cow Manure on the Vermicompost Process of Household Organic Waste
Authors: Pradnya I N , Am A I , Pradani H R 
Published: June 2023

Abstract
High population growth in developing countries also increases the amount of waste. Indonesia produces large amount of household solid waste production, namely 2.5 kg per day. Vermicompost is the best alternatives, the cheapest and does not harm the environment. In this study, the vermicompost method was used, worm weight and ratio affected the N, P, and K content in the fertilizer. The results of the sample test, namely the vermicompost time variable, the highest content was obtained at week 7 with N of 0.45%; P of 0.25%; and K by 0.23%. In the variable weight of worms, the highest weight of 300 grams of worms with N of 0.41%; P of 0.34%; and K by 0.23%; and the last variable is the ratio of cow dung and vegetable waste, where the highest content is at a ratio of 1:3 with N of 0.42%; P of 0.27%, and K of 0.22%. The test in this study was taken with 2 samples of the same variable and 1 different variable to determine the effect of these different variables on the N, P, and K content of liquid compost. Then the samples were tested for content using the macro-Kjedahl method to determine the nitrogen content, UV/Vis spectrophotometry to determine the phosphorus content, and AAS to determine the total potassium content.
Physical activity and injurious falls in older Australian women: adjusted associations and modification by physical function limitation and frailty in the Australian Longitudinal Study on Women’s Health
Authors: Kwok Wing S , Dolja-Gore Xenia , Khalatbari-Soltani Saman , Byles Julie , Oliveira Juliana S , Pinheiro Marina B , Naganathan Vasi , Tiedemann Anne , Sherrington Catherine 
Published: June 2023

Abstract

Objectives
To investigate associations between leisure-time physical activity (LPA) and injurious falls in older women and explore modification of associations by physical function and frailty.

Methods
Women born during 1946–51 from the Australian Longitudinal Study on Women’s Health, injurious falls (self-reported fall with injury and/or medical attention) and self-reported weekly LPA (duration and type). We undertook cross-sectional and prospective analyses using data from 2016 [n = 8,171, mean (SD) age 68 (1)] and 2019 surveys (n = 7,057). Associations were quantified using directed acyclic graph-informed logistic regression and effect modification examined using product terms.

Results
Participation in LPA as recommended by World Health Organization (150–300 min/week) was associated with lower odds of injurious falls in cross-sectional (adjusted Odds Ratio (OR) 0.74, 95% CI 0.61–0.90) and prospective analyses (OR 0.75, 95% CI 0.60–0.94). Compared with those who reported no LPA, cross-sectionally, odds of injurious falls were lower in those who reported brisk walking (OR 0.77, 95% CI 0.67–0.89) and vigorous LPA (OR 0.86, 95% CI 0.75–1.00). No significant association was found between different types of LPA and injurious falls prospectively. Only cross-sectionally, physical function limitation and frailty modified the association between LPA and injurious falls, with tendencies for more injurious falls with more activity in those with physical limitation or frailty, and fewer injurious falls with more activity among those without physical function limitation or frailty.

Conclusion
Participation in recommended levels of LPA was associated with lower odds of injurious falls. Caution is required when promoting general physical activity among people with physical limitation or frailty.
Gemini: memory-efficient integration of hundreds of gene networks with high-order pooling
Authors: Woicik Addie , Zhang Mingxin , Xu Hanwen , Mostafavi Sara , Wang Sheng 
Published: June 2023

AbstractMotivationThe exponential growth of genomic sequencing data has created ever-expanding repositories of gene networks. Unsupervised network integration methods are critical to learn informative representations for each gene, which are later used as features for downstream applications. However, these network integration methods must be scalable to account for the increasing number of networks and robust to an uneven distribution of network types within hundreds of gene networks.ResultsTo address these needs, we present Gemini, a novel network integration method that uses memory-efficient high-order pooling to represent and weight each network according to its uniqueness. Gemini then mitigates the uneven network distribution through mixing up existing networks to create many new networks. We find that Gemini leads to more than a 10% improvement in F1 score, 15% improvement in micro-AUPRC, and 63% improvement in macro-AUPRC for human protein function prediction by integrating hundreds of networks from BioGRID, and that Gemini’s performance significantly improves when more networks are added to the input network collection, while Mashup and BIONIC embeddings’ performance deteriorates. Gemini thereby enables memory-efficient and informative network integration for large gene networks and can be used to massively integrate and analyze networks in other domains.Availability and implementationGemini can be accessed at: https://github.com/MinxZ/Gemini.
Genome-wide scans for selective sweeps using convolutional neural networks
Authors: Zhao Hanqing , Souilljee Matthijs , Pavlidis Pavlos , Alachiotis Nikolaos 
Published: June 2023

Abstract

Motivation
Recent methods for selective sweep detection cast the problem as a classification task and use summary statistics as features to capture region characteristics that are indicative of a selective sweep, thereby being sensitive to confounding factors. Furthermore, they are not designed to perform whole-genome scans or to estimate the extent of the genomic region that was affected by positive selection; both are required for identifying candidate genes and the time and strength of selection.

Results
We present ASDEC (https://github.com/pephco/ASDEC), a neural-network-based framework that can scan whole genomes for selective sweeps. ASDEC achieves similar classification performance to other convolutional neural network-based classifiers that rely on summary statistics, but it is trained 10× faster and classifies genomic regions 5× faster by inferring region characteristics from the raw sequence data directly. Deploying ASDEC for genomic scans achieved up to 15.2× higher sensitivity, 19.4× higher success rates, and 4× higher detection accuracy than state-of-the-art methods. We used ASDEC to scan human chromosome 1 of the Yoruba population (1000Genomes project), identifying nine known candidate genes.
Sperm induce macrophage extracellular trap formation via phagocytosis-dependent mechanism
Authors: Lu Chuncheng , Wu Zhao , Gao Hongbin , Li Haiyuan , Deng Renbin , Luo Ning , Fan Shipeng , Li Xi , He Danpeng , Zhao Hui 
Published: June 2023

Abstract
Infertility is a public health concern worldwide. Asthenozoospermia is a common cause of male infertility and is characterized by decreased motility. Sperm motility ensures that sperm migrate to complete fertilization. Macrophages are an essential component of innate immunity in the female reproductive tract. Macrophage extracellular traps are induced by various microorganisms to capture and mediate the clearance of microorganisms. The relationship between sperm and macrophage extracellular traps is unclear. The human monocyte leukemia (THP-1) cells differentiated by phorbol myristate acetate (PMA) are widely used as surrogate of human macrophages. This study investigated sperm-induced macrophage extracellular trap formation and clarified some of the mechanisms affecting macrophage extracellular trap production. Sperm-induced macrophage extracellular traps were visualized and components of macrophage extracellular traps were identified by immunofluorescence analyses and scanning electron microscopy. By inhibiting macrophage extracellular trap production and macrophage phagocytosis, the relationship between macrophage phagocytosis and macrophage extracellular trap production was analyzed. Sperm could trigger PMA-differentiated THP-1 macrophages to produce extracellular traps. Sperm-triggered macrophage extracellular traps are dependent on phagocytosis and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Sperm from asthenozoospermia donors are more likely to be phagocytosed by macrophages than sperm from healthy donors, which induce more macrophage extracellular trap release. These data confirm the phenomenon and partial mechanism of sperm-induced macrophage extracellular trap formation in vitro. These may partly provide evidence to explain the mechanisms of clearing abnormally morphological or hypomotile sperm in the female reproductive tract and the rationale for the decreased probability of successful fertilization in asthenozoospermia.
O027 Less is more: extensive cardiac investigations add little value in waitlisting patients for kidney transplantation
Authors: Chow BJ , Khurram MA , Capuano E , Pugliese F , Yaqoob MM , Mohamed IH 
Published: June 2023

Abstract

Introduction
The utility and reliability of extensive cardiac investigations to aid waitlisting for kidney transplantation has been debated. This study assessed the prognostic power of coronary artery calcium scoring (CACS) using computed tomography coronary angiogram (CTCA) and myocardial perfusion scintigraphy (MPS) in predicting major adverse cardiac events (MACE).

Methods
We conducted a retrospective study of all ESRD patients considered for kidney transplantation and referred for MPS and/or CTCA for CACS between October 2012 to March 2014 and assessed MACE occurrences (heart failure, cardiac arrest, myocardial infarction, angina, CVA, PVD and transient ischaemic attack) over a 9-year follow-up period.

Results
Among 131 patients in our study, 91.6% had a MPS (76.7% Negative MPS result, 23.3% Positive MPS) and 92.4% had a CTCA (75.2% CACS &lt;400 (Low Score), 24.8% CACS&gt;400 (High Score)). Sensitivity, specificity, positive and negative predictive values were poor for CTCA (38.8%, 84.7%, 63.3%, 67.0%) and MPS (34.8%, 82.4%, 55.2%, 67.0%). There was no statistical significance in MACE when stratified by CACS and MPS in transplanted patients (log-rank p=0.155); statistical significance observed when stratified by transplant status in all patients (p=&lt;0.0001). No statistical difference in MACE observed when stratified by MPS (p=0.749) or CACS (p=0.706) in non-transplanted patients.

Conclusion
This challenges the value of extensive cardiac assessments (MPS, CTCA) in predicting MACE. Candidates conventionally considered low-risk by these methods had similar risk of MACE when transplanted against higher-risk groups. Transplantation confers an advantage in MACE-free years. Such tests are best used for risk stratification and counselling for shared decision-making.

Take-home message
Extensive cardiac investigations such as MPS and CTCA are poor predictors of MACE in end-stage renal disease patients. These tests should not be used as key determinants in waitlisting patients for kidney transplantation.
O048 Levosimendin use in high-risk cardiac patients - is it about timing?
Authors: Peacock T , Anderson B 
Published: June 2023

Abstract

Introduction
Use of levosimendan pre-operatively has had mixed outcomes for cardiac patients with low ventricular ejection fraction (EF). Whilst studies have examined the effects of immediate preoperative and intraoperative administration, outcomes of administration one week prior to surgical intervention have not been evaluated. The aims of this study were to compare cardiac parameters pre and post administration of levosimendan one week prior to surgery.

Method
A retrospective analysis was conducted of high-risk patients undergoing cardiac surgery. Patients with an EF of &lt;50% were included. Baseline EF, pulmonary artery pressures (PAP), cardiac output (CO) and cardiac index (CI) were measured utilising transthoracic echocardiogram. A weight-based dose of levosimendan was administered one week prior to intervention. Measures were repeated pre-operatively, one week after administration of levosimendan (0.2mg/Kg).

Results
A total of 100 patients were included in this study. The mean time from dose of levosimendan to operative time was 11 days. Mean EF, systolic PAP, mean PAP, CO, and CI were 43.63%, 48.71mmHg, 29.97mmHg, 4.84L/min, and 2.47L/min/m2 respectively. Each parameter showed significant improvement one week post levosimendan; 48.42% (p=0.011, SE 4.7, 1.8–1.2 95% CI), 35.06mmHg (p= &lt;0.001, SE 13.65, 11.2–16.0 95% CI), 21.58mmHg (p= &lt;0.001, SE 8.4, 6.6–10.1 95% CI), 5.64L/min (p= &lt;0.001, SE 0.8, 0.6 to 1 95% CI), and 2.88L/min/m2 (p&lt;0.001, SE 0.4, 0.3–0.5 95% CI) respectively. Overall, 30-day mortality was 3% (n=3), compared to an expected mortality of 5.02%.

Take-home message
Levosimendan shows promise in improving pre-operative cardiac function when given one week prior to intervention in high-risk cardiac patients.
EP-601 Biodegradable stents for benign oesophageal strictures- a single centre experience
Authors: Obuobi Reece-Bolton , Viswanath Yirupaiahgari 
Published: June 2023

Abstract
Biodegradable (BD) stents have been used for the management of various oesophageal strictures (ES). The present study aim to evaluate our experience and efficacy of BD stents in benign ES at the endoscopic unit at the James Cook University Hospital, Middlesbrough, UK.

Methods
A retrospective review of case notes of 9 patients who have undergone endoscopically placement of BD stent for benign ES between March 2010 and November 2020. All 9 patients underwent successful stent placement. None of the patients had previous surgery for their condition. All patients, prior to stenting had oesophageal dilatations, some multiple times.

Results
Stent placement was successful in all 9 patients. Some patients had stent migration and subsequent re stenting. All patients had benign ES as the cause of dysphagia. One patient had caustic oesophageal stricture, remaining eight had peptic ulceration and GORD as the cause of dysphagia. The median number of dilatations prior to stent placement was 4 (IQR 7), more than the median number of dilatations post stent placement which was 2.0 (IQR: 3.5).

Conclusion
BD stents offers prolonged dilatation-free interval and reduces the number dilatations in patients with benign oesophageal strictures.