bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Trends in Nanocarriers for the Management of Atopic Dermatitis
Authors: Kumar Pravin , Ashawat Mahendra Singh , Pandit Vinay , Singh Verma Chandra Pal , Ankalgi Amar Deep , Kumar Manish 
Published: March 2023

Background:
Atopic dermatitis (AD) is a pruritic inflammatory skin condition with increasing
global prevalence, almost affecting 15% to 30% of children and 5% of adults. AD results due to a
complex interaction between the impaired skin barrier function, allergens, and immunological cells.
Topical corticosteroids or calcineurin inhibitors in the form of creams or ointments are the mainstay of
therapy, but they have low skin penetration and skin barrier repair efficiency.

Objective:
The above limitations of conventional dosage forms have motivated the development of
nanoformulations of drugs for improved penetration and deposition in the skin for better management of
AD.

Methods:
Databases, such as Pubmed, Elsevier, and Google Scholar, were reviewed for the investigations
or reviews published related to the title.

Results:
The present review discusses the advantages of nanoformulations for the management of AD.
Further, it also discusses the various types of topically investigated nanoformulations, i.e., polymeric
nanoparticles, inorganic nanoparticles, solid lipid nanoparticles, liposomes, ethosomes, transfersomes,
cubosomes, and nanoemulsion for the management of atopic dermatitis. In addition, it also discusses
advancements in nanoformulations, such as nanofibres, nanosponges, micelles, and nanoformulations
embedded textiles development for the management of AD.

Conclusion:
The nanoformulations of drugs can be a better alternative for the topical management of
AD with enhanced skin penetration and deposition of drugs with reduced systemic side effects and better
patient compliance.
Chemo-enzymatic Synthesis of Rivastigmine Intermediate by Locally
Isolated Soil Fungus Fusarium graminearum
Authors: Basingi Suneelkumar Muragesh M. , Matadh Siddesh 
Published: March 2023

Background:
Biocatalytic reactions are known as a green technology, capable of delivering
highly stereo-, chemo- and regioselective transformations that usually reduce the number of steps in a
synthetic route

Objective:
This work describes a process for the production of a key chiral intermediate N-ethyl-Nmethyl-carbamic acid-3-(1S-hydroxy-ethyl)-phenyl ester converted into chiral alcohol which can be further converted into rivastigmine

Methods:
The fungi isolated from different soil samples by the soil dilution plate technique were screened
for their ability to convert the selected intermediate. The selected organism is further grown under fermentation for gram scale conversion.

Results:
Among the different fungi isolated Fusarium graminearum selected for further study for reaction
optimization and gram scale conversion of the ketone substrate

Conclusion:
The reaction under fermentative condition for 48 hours at 30°C, pH 6 with agitation speed of
200rpm found to be optimal condition for the overall bioreduction process of the ketone employed in the study.
A New, Ecological and Stability-indicating Method by HPLC for the
Quantification of Moxifloxacin in Tablets
Authors: da Silva Thaisa Alves Celedonio , da Silva Júnior João Roberto , Kogawa Ana Carolina 
Published: March 2023

Introduction:
A new, ecological, and stability-indicating method by HPLC was developed for
the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2%
phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1
, injection volume of 5 µL, and detection at 290 nm was used.

Methods:
The method was linear (2-12 µgmL-1
), selective, accurate (100.86%), precise (RSD<2%), and
robust.

Results:
The retention time for moxifloxacin in tablets was approximately 4.4 minutes.

Conclusion:
To sum up, a method based on the principles of green analytical chemistry was successfully
developed and validated for the quantification of moxifloxacin in tablets
Outpatient Intravenous Remdesivir to Prevent Progression to
Severe COVID-19: An Observational Study from a Greek Hospital
Authors: Kintrilis Nikolaos , Galinos Iosif 
Published: March 2023

Background:
Remdesivir, a viral RNA polymerase inhibitor, has been a powerful
weapon in the battle against the SARS-CoV-2 pandemic. Originally approved for use in
hospitalized patients, remdesivir improves clinical outcomes in patients with moderate to
severe coronavirus disease 2019 (COVID-19). After proving efficacious in hospitalized
patients, its use was approved in early disease for symptomatic, non-hospitalized patients
that present risk factors for progression to severe disease.

Objective:
To evaluate whether administration of the antiviral medication remdesivir at an
outpatient basis has an effect on hospital admissions of patients presenting with SARSCoV-
2 infection.

Methods:
We conducted an observational clinical trial involving 107 non-hospitalized
COVID-19 patients who attended the emergency department of a third-level greek hospital
seeking care for symptoms appearing within the previous 5 days and who had at least one
risk factor for progression to severe disease. After arterial blood gas evaluation, eligible
patients received intravenous remdesivir at a dose of 200 mg on day 1 and 100 mg on days
2 and 3. The efficacy endpoint was set as COVID-19-related hospitalization or death in the
next 14 days.

Results:
A total of 107 patients (57.0% men) participated in the study, 51 (47.7%) of them
fully vaccinated. Most prevalent were age ≥ 60 years old, cardiovascular/cerebrovascular
disease, immunosuppression or malignancy, obesity, diabetes mellitus, and chronic lung
disease. All patients enrolled completed the 3-day course, with a total of 3 out of 107 patients
(2.8%) eventually having a COVID-19-related hospitalization by day 14, while no
deaths were reported by day 14.

Conclusion:
Among non-hospitalized patients with at least one risk factor for progression
to severe COVID-19, a 3-day course of intravenous remdesivir yielded favourable results.
Evaluation of the efficiency of the different methods of teaching cardiopulmonary resuscitation to children and adolescents: integrative review
Authors: Franco de Oliveira Martins Laura , Bonine Melo Ana Júlia , Reis Daniel Brito , Alves Mateus Goulart 
Published: March 2023

Objective: To evaluate the efficiency of different teaching methods of Basic Life Support for lay students from 12 years of age. Methods: A search was carried out for articles on the MEDLINE/PubMed and Lilacs/BVS platforms between December 2021 and January 2022 to answer the guiding question, "How effective are the different teaching methods of cardiopulmonary resuscitation for children and adolescents?". Articles published in English and Portuguese in the last five years were included. Results: Seven articles addressed teaching methods: self-regulated learning, training of teachers followed by students, peer education, online teaching associated with practical self-training, distance learning, digital training added to practice, and application use through a tablet with subsequent evaluation. In all studies, there was a comparison between intervention and conventional training. In general, all teaching methods contributed to developing the ability to act in trauma situations, but strategies that involved the presence of instructors in training showed better short- and long-term results. Conclusion: this study verified the findings in the literature regarding the effectiveness of different BLS teaching methods for children and adolescents. Among all approaches, better performance was observed in methods that had the presence of instructors, who offered feedback to students and reduced distractions. However, digital, self-regulated, and peer teaching also proved viable. Therefore, the choice of method should be based on the target audience's reality.
Social Support Among Women With Potential Essure-Related Complaints: Analysis of Facebook Group Content
Authors: van Gastel Daniëlle , Antheunis Marjolijn L , Tenfelde Kim , van de Graaf Daniëlle L , Geerts Marieke , Nieboer Theodoor E , Bongers Marlies Y 
Published: March 2023

Background
Social support groups are an important resource for people to cope with problems. Previous studies have reported the different types of support in these groups, but little is known about the type of reactions that sharing of personal experiences induce among members. It is important to know how and to what extent members of support groups influence each other regarding the consumption of medical care. We researched this in a web-based Facebook group of women sterilized with Essure. Essure was a device intended for permanent contraception. From 2015 onward, women treated with Essure for tubal occlusion raised safety concerns and numerous complaints.

Objective
This study aimed to evaluate the use of social support in a Facebook community named “Essure problemen Nederland” (EPN; in English, “Essure problems in the Netherlands”).

Methods
All posts in the closed Facebook group EPN between March 8 and May 8, 2018, were included. In total, 3491 Facebook posts were analyzed using a modified version of the Social Support Behavior Codes framework created by Cutrona and Suhr in 1992. Posts were abstracted and aggregated into a database. Two investigators evaluated the posts, developed a modified version of the Social Support Behavior Codes framework, and applied the codes to the collected data.

Results
We found that 92% of messages contained a form of social support. In 68.8% of posts, social support was provided, and in 31.2% of posts, social support was received. Informational and emotional support was the most frequently used form of provided social support (40.6% and 55.5%, respectively). The same distribution was seen with received social support: informational support in 81.5% and emotional support in 17.4% of cases. Our analysis showed a strong correlation between providing or receiving social support and the main form of social support (P<.001). In a total of only 74 (2.2%) cases, women advised each other to seek medical care.

Conclusions
The main purpose of women in the EPN Facebook group was to provide and receive informational or emotional support or both.
Conditioning of the Cortisol Awakening Response in Healthy Men: Study Protocol for a Randomized Controlled Trial
Authors: Wolters Fabian , van Middendorp Henriët , Van den Bergh Omer , Biermasz Nienke R , Meijer Onno C , Evers Andrea WM 
Published: March 2023

Background
The hormone cortisol plays important roles in human circadian and stress physiology and is an interesting target for interventions. Cortisol varies not only in response to stress but also as part of a diurnal rhythm. It shows a particularly sharp increase immediately after awakening, the cortisol awakening response (CAR). Cortisol can be affected by medication, but it is less clear whether it can also be affected by learning. Animal studies have consistently shown that cortisol can be affected by pharmacological conditioning, but the results in humans have been mixed. Other studies have suggested that conditioning is also possible during sleep and that the diurnal rhythm can be conditioned, but these findings have not yet been applied to cortisol conditioning.

Objective
The objective of our study was to introduce a novel avenue for conditioning cortisol: by using the CAR as an unconditioned response and using scent conditioning while the participant is asleep. This study investigates an innovative way to study the effects of conditioning on cortisol and the diurnal rhythm, using a variety of devices and measures to make measurement possible at a distance and at unusual moments.

Methods
The study protocol takes 2 weeks and is performed from the participant’s home. Measures in week 1 are taken to reflect the CAR and waking under baseline conditions. For the first 3 nights of week 2, participants are exposed to a scent from 30 minutes before awakening until their normal time of awakening to allow the scent to become associated with the CAR. On the final night, participants are forced to wake 4 hours earlier, when cortisol levels are normally low, and either the same (conditioned group) or a different (control group) scent is presented half an hour before this new time. This allows us to test whether cortisol levels are higher after the same scent is presented. The primary outcome is the CAR, assessed by saliva cortisol levels, 0, 15, 30, and 45 minutes after awakening. The secondary outcomes are heart rate variability, actigraphy measures taken during sleep, and self-reported mood after awakening. To perform manipulations and measurements, this study uses wearable devices, 2 smartphone apps, web-based questionnaires, and a programmed scent device.

Results
We completed data collection as of December 24, 2021.

Conclusions
This study can provide new insights into learning effects on cortisol and the diurnal rhythm. If the procedure does affect the CAR and associated measures, it also has potential clinical implications in the treatment of sleep and stress disorders.

Trial Registration
Netherlands Trial Register NL58792.058.16; https://trialsearch.who.int/Trial2.aspx?TrialID=NL7791

International Registered Report Identifier (IRRID)
DERR1-10.2196/38087
Government's legal policy on the protection of women and children pre- and post-illegal marriages
Authors: Rahmatillah Syarifah , Bustamam Amrullah 
Published: March 2023

This study focuses on efforts made by the Aceh government to protect women and children before and after illegal marriages. The author uses a victimology theory approach to see the efforts made by the government in these cases. The author examines two problems; how the modus operandi of illegal marriage under state law occurs in Aceh and what countermeasures the Aceh Government has taken to protect women and children of Pre and Post-Illegal Marriage in Aceh. This research is a combination of Normative and Empirical research. The results indicate that the modus operandi of illegal marriage under state law occurs in Aceh includes siri marriage (unofficial, unregistered marriage) and its legal consequences, illegal polygamy by civil servants, early marriage, polyandrous marriage, Cina Buta marriage (muhallil or a proponent to reconcile a couple (wife and husband) who had divorced by triple divorce).The countermeasures implemented by the Aceh Government to protect women and children Pre and Post Illegal Marriage in Aceh include: conducting socialization to secondary schools about marriage following state law, issuing Aceh Governor Regulation no.25 of 2017 concerning the implementation of one-day service marriage validation (isbath nikah -marriage legalization- program during the conflict and tsunami), isbath nikah as a benchmark for data on the number of siri marriages, marriage dispensation for early marriage by teenagers, qanun policy on legalizing polygamy through qanun family law in Aceh illegal polygamy, and implementation of The Constitutional Court decisions on civil recognition of the status of children out of wedlock with biological fathers.
The Study of The Attitude to Time of Representatives the Net Generations Y and Z with Different Levels of Leadership Qualities
Authors: Dautov D. F. , Chalkova E. A. 
Published: March 2023

Introduction. Psychological features of generations Y and Z representatives are described. The relation to time is considered both as the basis for the perception of the content of the human activity and as an element dependent on it.Purpose. The study is aimed to establish the peculiarities of the attitude to time among representatives of generations Y and Z with differences in the severity of leadership qualities.Materials and Methods. The main methods of empirical research are presented: Temporal Decentrations by Golovakha and Kronik; I Am a Leader by Fedorov and Eremin; Diagnostics of Leadership Abilities by Zharikova and Krushelnitsky; Time Experience Scale by Golovakha and Kronik. The sample description is given: 51 representatives of generations Y and Z, male and female, aged 19‒38 years.Results. The connections between indicators of leadership qualities expressed by the scale’s high and medium level; between the indicators of temporal decentralization ‘orientation to the past’; between the indicators of leadership abilities shown by the scales ‘low and medium’ and such scales of time experience as ‘empty’, ‘saturated’, ‘flowing slowly’, ‘flowing fast’, ‘unlimited’, ‘limited’, ‘monotonous’ and ‘multifarious’.Discussion and Сonclusion. The peculiarities of the attitude to time are described in connection with the leadership qualities of the Net Generations Y and Z representatives. A comparative analysis of leadership qualities severity among representatives of different generations is carried out. The presence of higher leadership potential in generation Y is emphasized. The data obtained can be used to establish more productive relationships between teachers and students.
Analisis Stabilitas dan Kontrol Optimal Model Matematika Kecanduan Game Online
Authors: Karimah Putri 
Published: March 2023

Online games as multimedia can create high interest in users, especially online games that use interaction. This if done in the long term will result in negative impacts. Currently, there are many online game competitions known as esports. The players who are involved with esports are referred to as professionals, although their playing time is the same as online game addicts, they are different from ordinary online game addicts. So, in this article, the author constructs a mathematical model of online game addiction into four compartments (susceptible, infective, professional and quitting compartments) by considering the direct transfer of the vulnerable population to the professional population. The author conducted a stability analysis of the model equilibrium point where there are two equilibrium points and also obtained the basic reproduction number . By using Pontriagin's maximum principle, a solution for optimal control is obtained using control variables and in order to obtain an optimal condition.
Analisis Regresi Logistik Biner pada Faktor-faktor yang Mempengaruhi Kesediaan Masyarakat Nagari Paninjauan untuk Divaksinasi Covid-19
Authors: Febrianti Febrianti , Helma Helma 
Published: March 2023

Tingkat vaksinasi Covid-19 di Nagari Paninjauan, Kabupaten Agam masih tergolong rendah. Beberapa faktor penyebabnya antara lain, penyakit bawaan, ketakutan efek samping, keefektivitasan vaksin, dan kehalalan vaksin. Penelitian ini memiliki tujuan untuk mencari faktor-faktor yang berpengaruh pada kesediaan masyarakat untuk divaksinasi. Penelitian ini memiliki populasi yang berjumlah 500 responden. Sampel pada penelitian ini berjumlah 83 responden didapat menggunakan metode Cluster Random Sampling. Kesediaan masyarakat divaksinasi Covid-19 sebagai variabel (Y) dan pemahaman terhadap vaksin (X_1), kekhawatiran (X_2), informasi hoaks (X_3), penerapan protokol kesehatan (X_4), pekerjaan (X_5), pemaksaan karena bekerja (X_6), usia (X_7), jenis kelamin (X_8) sebagai variabel.bebasnya dalam mencocokkan model. Hasil dari penelitian ini menunjukkan,,model regresi logistik biner yaitu.. π(x)=(exp (-17,171+2,760x_1-2,813x_3+3,778x_7+3,546x_8 ))/(1+exp⁡〖((-17,171+2,760x_1-2,813x_3+3,778x_7+3,546x_8 )),〗 dimana pemahaman terhadap vaksin, informasi hoaks, usia, dan jenis kelamin berpengaruh...signifikan terhadap kesediaan masyarakat untuk vaksinasi Covid-19.Tingkat vaksinasi Covid-19 di Nagari Paninjauan, Kabupaten Agam masih tergolong rendah. Beberapa faktor penyebabnya antara lain, penyakit bawaan, ketakutan efek samping, keefektivitasan vaksin, dan kehalalan vaksin. Penelitian ini memiliki tujuan untuk mencari faktor-faktor yang berpengaruh pada kesediaan masyarakat untuk divaksinasi. Penelitian ini memiliki populasi yang berjumlah 500 responden. Sampel pada penelitian ini berjumlah 83 responden didapat menggunakan metode Cluster Random Sampling. Kesediaan masyarakat divaksinasi Covid-19 sebagai variabel (Y) dan pemahaman terhadap vaksin (X_1), kekhawatiran (X_2), informasi hoaks (X_3), penerapan protokol kesehatan (X_4), pekerjaan (X_5), pemaksaan karena bekerja (X_6), usia (X_7), jenis kelamin (X_8) sebagai variabel.bebasnya dalam mencocokkan model. Hasil dari penelitian ini menunjukkan,,model regresi logistik biner yaitu.. π(x)=(exp (-17,171+2,760x_1-2,813x_3+3,778x_7+3,546x_8 ))/(1+exp⁡〖((-17,171+2,760x_1-2,813x_3+3,778x_7+3,546x_8 )),〗 dimana pemahaman terhadap vaksin, informasi hoaks, usia, dan jenis kelamin berpengaruh...signifikan terhadap kesediaan masyarakat untuk vaksinasi Covid-19.
THE CONTROVERSY OVER SAMPRADAYA AND THE DYNAMICS OF HINDU INSTITUTION: CONTESTATION OF HINDU ELITES IN PALANGKA RAYA CITY
Authors: Adi Agung , Suastra I Made , Yudha Triguna Ida Bagus Gde , Pujaastawa Ida Bagus Gde 
Published: March 2023

This article is intended to analyze the controversy over sampradaya and the dynamics of Hindu institutions in general and ‘The Indonesia Administrative Council of Hindu Dharma’ Parisada Hindu Dharma Indonesia (PHDI) in particular in Palangka Raya City. The existence of sampradaya, as a transnational organization, has triggered an internal contestation among the Hindu elites. Being a qualitative study, this current study applies the approach of cultural studies, and emphasizes the different ways of interpreting one phenomenon. The data were obtained from the informants purposively chosen; therefore, they are categorized as the primary data source. The secondary data were obtained from the online and offline books available in the library, documents, articles and research results. The data were analyzed interactively in which Milles and Huberman were referred to. The data analysis includes the data reduction, the data presentation, the conclusion withdrawal or the data verification and interpretation. The results and discussion show that the controversy and contestation more dominantly result from the impact of globalization indicated by the dialectic process of affecting each other between the particularity referring to the symbols of the Bali Hindu identity, as one of the Hindu identities in Indonesia which is obliged to be maintained, and the universality, as the Hindu identity referring to the Indian culture, whose followers have spread all over the world.
Keywords: sampradaya, PHDI, elite, Bali Hindu
Dampak Alih Fungsi Lahan terhadap Eksistensi Subak Kedungu, di Desa Pererenan, Kecamatan Mengwi, Kabupaten Badung
Authors: LESMANA I KADEK ADI YOGA , SUAMBA I KETUT , ASTITI NI WAYAN SRI 
Published: March 2023

The Impact of Land Functions on the Existence of Subak Kedungu, Pererenan Village, Mengwi District, Badung Regency
Subak is very thick in community life in Bali. Subak is closely related to Tri Hita Karana, which is a guideline for the community in religious social activities carried out by the indigenous community in Bali.The purpose of this study is to determine the impact of land use change and the causes of land use change on the existence of Subak Kedungu in terms of social, economic and technical aspects.The location of this research was conducted in Subak Kedungu, Pererenan Village, Mengwi District, Badung Regency from November 2020 to January 2021.The selection of the research location was carried out by using the perposive method using key informants.The determination of informants in this study involved all elements related to the Kedungu Subak, such as members of the subak, subak landowners, subak members who sold land, tenants, tenants, subak institutions, and village institutions.The results showed the causes of land conversion that occurred in Subak Kedungu, among others, an increase in the number of family members, an increase in community needs, and a decrease in the interest of young people in Pererenan Village to replace their parents as farmers.Meanwhile, the impact of land conversion that occurs is that the social aspects do not have an impact on the community, the economic aspect of income from farming does not experience a reduction, and the technical aspects are not too affected because basically the members of Subak Kedungu only plant rice.