bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nasal Endoscopic Features of Postnasal Drip: A Cross Sectional Study
Authors: Tarmizi Nur Eliana , Hamizan Aneeza Wan , Ng Chong Sian , Gendeh Hardip Singh , Guan Lum Sai , Zahedi Farah Dayana , Baki Marina Mat , Husain Salina 
Published: May 2023

Abstract
Introduction Patients with chronic rhinitis suffer from postnasal drip (PND) but this symptom is not well addressed. Nasal endoscopy may aid in identifying PND. Well described endoscopic features of PND are presence of secretions in the posterior nasal cavity, diffuse erythema, and hemorrhagic spots in the nasopharynx, but these have not been formally studied.
Objectives The present study aims to assess the association of nasal endoscopic features with PND among rhinitis patients. This will guide clinicians to interpret the nasal endoscopic findings appropriately.
Methods Adults (≥ 18 years old) with chronic rhinitis were consecutively recruited at an Otorhinolaryngology outpatient clinic in a tertiary referral center. The patients were grouped into either “Rhinitis with PND” or “Rhinitis only.” The endoscopic features of PND were scored as: Secretions in the posterior nasal cavity (yes/no), erythema in the nasopharynx (none, roof only, diffuse), hemorrhagic spots (yes/no), then were compared between groups.
Results There were 98 patients included (age 32.32 ± 11.33 years old, 61.2% female, 61.2% PND). Presence of secretions in the posterior nasal cavity was associated with PND (“Rhinitis with PND” versus “Rhinitis only,” 78.3 versus 55.3; p = 0.02; Odds ratio: 2.81; 95% confidence interval [CI]: 1.08–7.32). Diffuse erythema of the nasopharynx was more frequent in “rhinitis only” compared with those with PND (76.3 versus 53.3%; p = 0.02). Hemorrhagic spots were equally present in both groups (11.7 versus 18.4%; p = 0.35).
Conclusion Presence of secretions in the posterior nasal cavity may indicate bothersome PND among patients with rhinitis. Diffuse erythema of the nasopharynx and hemorrhagic spots are a nonspecific sign of inflammation.
Degenerative Spondylolisthesis of Lumbarized S1-S2 Vertebrae: A Case Report
Authors: Singh Deepak Kumar , Sinha Kshitij , Singh Rakesh Kumar , Chand Vipin Kumar , Singh Arun Kumar 
Published: May 2023

Abstract
Introduction Degenerative spondylolisthesis (DS) is usually seen at lumbo-sacral region. Lumbarization of S1 is seen in less than 2% of the population and to have spondylolisthesis in this segment is even rarer. The purpose is to report a rare case of DS at S1-S2 level.
Case Report A 52-year-old male, a farmer by profession, presented to Neurosurgery outpatient department with complaint of low back ache for 4 years, which was insidious and progressive. The pain radiated to both lower limbs with more on right than left side. Radiological evaluation with anteroposterior and lateral roentgenogram of lumbo-sacral spine revealed anterolisthesis of S1-S2 (Meyerding's grade 2). Magnetic resonance imaging reported S1-S2 disk bulge with bilateral foraminal stenosis. The patient underwent S1 laminectomy along with S1-S2 discectomy with bilateral S1 and S2 pedicle screws and rod fixation with transforaminal lumbar interbody fusion.
Result Postoperative recovery was good with improvement in back pain along with power on postoperative day 1.
Conclusion The prevalence of lumbarization is less than 2% and getting spondylolisthesis in this segment is even rarer. As this is one of the first of its kind of case, further case series or longitudinal studies of such cases may help understand better the pathomechanics related to spondylolisthesis at this level.
A Child with KMT2B-Related Acute-Onset Dystonia: Clinical Pointers to Molecular Diagnosis
Authors: Singh Ankur , Sucheta Sucheta , Abhinay Abhishek , Prasad Rajniti 
Published: May 2023

AbstractDystonia is common extrapyramidal presentation of neurological problems in childhood. The causes could range from infectious, autoimmune, drug-induced, or genetic in origin. Genetic causes are rare in origin but could masquerade the common causes. Recently, KMT2B-related dystonia has been identified as a common genetic cause of dystonia in childhood. We present a case of a 3.5-year-old with 18 months of follow-up, who was diagnosed with KMT2B-related dystonia and managed with antidystonia drugs to an acceptable level where she could perform her day-to-day work with ease. Here, we highlight certain clinical pointers of the disease and the need of special genetic test in diagnosing such cases. We also tabulated the three previously reported Indian cases and compared their parameter with ours.
Use of dry-matter intake recorded at multiple time periods during lactation increases the accuracy of genomic prediction for dry-matter intake and residual feed intake in dairy cattle
Authors: Bolormaa Sunduimijid , Haile-Mariam Mekonnen , Marett Leah C. , Miglior Filippo , Baes Christine F. , Schenkel Flavio S. , Connor Erin E. , Manzanilla-Pech Coralia I. V. , Wall Eileen , Coffey Mike P. , Goddard Michael E. , MacLeod Iona M. , Pryce Jennie E. 
Published: May 2023

Context Feed is the largest expense on a dairy farm, therefore improving feed efficiency is important. Recording dry-matter intake (DMI) is a prerequisite for calculating feed efficiency. Genetic variation of feed intake and feed efficiency varies across lactation stages and parities. DMI is an expensive and difficult-to-measure trait. This raises the question of which time periods during lactation would be most appropriate to measure DMI. Aims The aim was to evaluate whether sequence variants selected from genome-wide association studies (GWAS) for DMI recorded at multiple lactation time periods and parities would increase the accuracy of genomic estimated breeding values (GEBVs) for DMI and residual feed intake (RFI). Methods Data of 2274 overseas lactating cows were used for the GWAS to select sequence variants. GWAS was performed using the average of the DMI phenotypes in a 30-day window of six different time periods across the lactation. The most significant sequence variants were selected from the GWAS at each time period for either first or later parities. GEBVs for DMI and RFI in Australian lactating cows were estimated using BayesRC with 50 k single nucleotide polymorphisms (SNPs) and selected GWAS sequence variants. Key results There were differences in DMI genomic correlations and heritabilities between first and later parities and within parity across lactation time periods. Compared with using 50 k single-nucleotide polymorphisms (SNPs) only, the accuracy of DMI GEBVs increased by up to 11% by using the 50 k SNPs plus the selected sequence variants. Compared with DMI, the increase in accuracy for RFI was lower (by 6%) likely because the sequence variants were selected from GWAS for DMI not RFI. The accuracies for DMI and RFI GEBVs were highest by using selected sequence variants from the DMI GWAS in the mid- to late-lactation periods in later parity. Conclusions Our results showed that DMI phenotypes in late lactation time periods could capture more genetic variation and increase genomic prediction accuracy through the use of custom genotype panels in genomic selection. Implications Collecting DMI at the optimal time period(s) of lactation may help develop more accurate and cost-effective breeding values for feed efficiency in dairy cattle.
4f photoabsorption in Pt+ to Pt4+
Authors: Doyle Eric , O’Sullivan Gerry , Hayden Patrick , Dunne Padraig 
Published: May 2023

Abstract
Detailed knowledge of the inner-shell atomic structure of lowly-ionised species is lacking for most elements along the sixth row of the periodic table, from hafnium to bismuth. This paper presents 4f-photoabsorption spectra of Pt+ to Pt4+ ions, recorded between 69 and 127 eV (9.8 nm and 18 nm) using the dual laser plasma method. Analysis of the spectra was supported by atomic structure calculations using the Cowan suite of codes, by relativistic time-dependent local-density approximation (RTDLDA) calculations, and by comparison along isoelectronic series, particularly with spectra of lowly-ionised gold plasmas. The RTDLDA calculations account for the influence of photoionisation and photoexcitation on the recorded spectra. The spectra show 4f

→

5d, 6d, and 7d transitions, broadened by autoionisation.
Painlevé integrability and a collection of new wave structures related to an important model in shallow water waves
Authors: Murtaza Isma Ghulam , Raza Nauman , Arshed Saima 
Published: May 2023

Abstract
This paper investigates the perturbed Boussinesq equation that emerges in shallow water waves. The perturbed Boussinesq equation describes the properties of longitudinal waves in bars, long water waves, plasma waves, quantum mechanics, acoustic waves, nonlinear optics, and other phenomena. As a result, the governing model has significant importance in its own right. The singular manifold method and the unified methods are employed in the proposed model for extracting hyperbolic, trigonometric, and rational function solutions. These solutions may be useful in determining the underlying context of the physical incidents. It is worth noting that the executed methods are skilled and effective for examining nonlinear evaluation equations, compatible with computer algebra, and provide a wide range of wave solutions. In addition to this, the Painlevé test is also used to check the integrability of the governing model. Two-dimensional and three-dimensional plots are made to illustrate the physical behavior of the newly obtained exact solutions. This makes the study of exact solutions to other nonlinear evaluation equations using the singular manifold method and unified technique prospective and deserving of further study.
Higher-dimensional integrable deformations of the modified KdV equation
Authors: Hao Xiazhi , Lou S Y 
Published: May 2023

Abstract
The derivation of nonlinear integrable evolution partial differential equations in higher dimensions has always been the holy grail in the field of integrability. The well-known modified KdV equation is a prototypical example of an integrable evolution equation in one spatial dimension. Do there exist integrable analogs of the modified KdV equation in higher spatial dimensions? In what follows, we present a positive answer to this question. In particular, rewriting the (1+1)-dimensional integrable modified KdV equation in conservation forms and adding deformation mappings during the process allows one to construct higher-dimensional integrable equations. Further, we illustrate this idea with examples from the modified KdV hierarchy and also present the Lax pairs of these higher-dimensional integrable evolution equations.
The Way to Quench: Galaxy Evolution in A2142
Authors: Qu Cheng-Gong , Yu Heng , Diaferio Antonaldo , Sohn Jubee , Liu DengQi 
Published: May 2023

Abstract
We show how the star formation activity of galaxies is progressively inhibited from the outer region to the center of the massive cluster A2142. From an extended spectroscopic redshift survey of 2239 galaxies covering a circular area of radius ∼11 Mpc from the cluster center, we extract a sample of 333 galaxies with known stellar mass, star formation rate, and spectral index D

n
4000. We use the Blooming Tree algorithm to identify the substructures of the cluster and separate the galaxy sample into substructure galaxies, halo galaxies, and outskirt galaxies. The substructure and halo galaxies are cluster members, whereas the outskirt galaxies are only weakly gravitationally bound to the cluster. For the cluster members, the star formation rate per stellar mass decreases with decreasing distance R from the cluster center. Similarly, the spectral index D

n
4000 increases with R, indicating an increasing average age of the stellar population in galaxies closer to the cluster center. In addition, star formation in substructure galaxies is generally more active than in halo galaxies and less active than in outskirt galaxies, proving that substructures tend to slow down the transition between field galaxies and cluster galaxies. We finally show that most actively star-forming galaxies are within the cluster infall region, whereas most galaxies in the central region are quiescent.
Phased Array Feed Experiments and Galactic H i Observations
Authors: Liu B. , Xi H. W. , Ding D. J. , Wang Z. W. , Yu S. H. , Zhu Y. , Yu L. , Zhang X. , Li J. L. , Liu L. J. , Su Q. , Wu Y. , Jin C. J. , Peng B. 
Published: May 2023

Abstract
The Phased Array Feed (PAF) is considered as one of the next generation receivers for radio telescopes, which can significantly enlarge the instantaneous Field-of-View of large aperture single dish radio telescopes and enable more flexible observing configurations. Study efforts on PAF development for radio telescopes have been made for more than two decades and have become more and more applicable. We report the development of an ambient-temperature 19 element L-band PAF system and the experimental results including its far field beam pattern and system temperature measurement, which achieve the expectations. Implementing the aperture array beam-forming method, we demonstrate a wide-field Galactic H i observations in the radio camera mode. The results indicate that this system might be applicable for strong Galactic transient detections. This system could be directly equipped to large telescopes like the Five-hundred-meter Aperture Spherical radio Telescope (FAST) and FAST array in the future.
Fall-risk-increasing drugs in older patients: the role of guidelines and GP-centred health care in Germany
Authors: Laux Gunter , Kaufmann-Kolle Petra , Szecsenyi Joachim , Altiner Attila , Leutgeb Ruediger 
Published: May 2023

Abstract

Background
fall-risk-increasing drugs (FRIDs) are a ubiquitous issue, especially for older patients. As part of a German guideline for pharmacotherapy, from 2019, a new quality indicator for this patient group was developed to measure the percentage of patients receiving FRIDs.

Methods
patients, aged at least 65 years in 2020, insured by the Allgemeine OrtsKrankenkasse statutory health insurance (Allgemeine Ortskrankenkasse, Baden-Wuerttemberg, Germany) with a particular general practitioner (GP) were observed from 1 January to 31 December 2020 cross-sectionally. The intervention group received GP-centred health care. Within GP-centred health care, GPs have the role of gatekeepers for patients within the health system and are—in contrast to regular care GPs in addition to other commitments—obliged to regularly attend training sessions on appropriate pharmacotherapy. The control group received regular GP care. For both groups, we measured the percentage of patients receiving FRIDs as well as the occurrence of (fall-related) fractures as the main outcomes. To test our hypotheses, we performed multivariable regression modelling.

Results
a total of 634,317 patients were eligible for analysis. Within the intervention group (n = 422,364), we could observe a significantly reduced odds ratio (OR) for obtaining a FRID (OR = 0.842, confidence interval [CI]: [0.826, 0.859], P &lt; 0.0001) in comparison to the control group (n = 211,953). Moreover, we could observe a significantly reduced chance for (fall-related) fractures in the intervention group (OR: 0.932, CI: [0.889, 0.975], P = 0.0071).

Conclusions
the findings point in the direction that the health care providers’ awareness of the potential danger of FRIDs for older patients is higher in the GP-centred care group.
Does frailty status predict outcome in major trauma in older people? A systematic review and meta-analysis
Authors: Alqarni Abdullah G , Gladman John R F , Obasi Akanu A , Ollivere Benjamin 
Published: May 2023

Abstract

Introduction
The incidence of major trauma in older people is increasing. Frailty is likely to be a factor that influences the outcomes of trauma. We conducted a systematic review aiming to investigate whether frailty affects major trauma outcomes in older people and whether it is more predictive than age.

Methods
Observational studies investigating frailty, major trauma severity and outcomes were eligible. We searched electronic databases (Ovid MEDLINE, PubMed, Ovid EMBASE and CINAHL) from 2010 to 01 January 2023. We used Joanna Briggs Institute software to assess the risk of bias and conduct meta-analyses of the relationships between frailty status and outcomes. We used a narrative synthesis to compare the predictive value of frailty and age.

Results
Twelve studies were eligible for meta-analyses. In-hospital mortality (odds ratio (OR) = 1.12, 95% confidence interval (CI) 1.05, 1.19), length of stay (OR = 2.04, 95% CI 1.51, 2.56), discharge to home (OR = 0.58, 95% CI 0.53, 0.63) and in-hospital complications (OR = 1.17, 95% CI 1.10, 1.24) were all associated with frailty. Frailty was found to be a more consistent predictor of adverse outcomes and mortality in older trauma patients than injury severity and age in six studies that reported multivariate regression analysis.

Discussion
Older trauma patients with frailty have higher in-hospital mortality rates, prolonged hospital stays, in-hospital complications and adverse discharge disposition. Frailty is a better predictor of adverse outcomes than age in these patients. Frailty status is likely to be a useful prognostic variable in guiding patient management and stratifying clinical benchmarks and research trials.
Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease
Authors: Tunold Jon-Anders , Tan Manuela M X , Koga Shunsuke , Geut Hanneke , Rozemuller Annemieke J M , Valentino Rebecca , Sekiya Hiroaki , Martin Nicholas B , Heckman Michael G , Bras Jose , Guerreiro Rita , Dickson Dennis W , Toft Mathias , van de Berg Wilma D J , Ross Owen A , Pihlstrøm Lasse 
Published: May 2023

AbstractIntraneuronal accumulation of misfolded α-synuclein is the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies, often co-occurring with variable degrees of Alzheimer’s disease related neuropathology. Genetic association studies have successfully identified common variants associated with disease risk and phenotypic traits in Lewy body disease, yet little is known about the genetic contribution to neuropathological heterogeneity.Using summary statistics from Parkinson’s disease and Alzheimer’s disease genome-wide association studies, we calculated polygenic risk scores and investigated the relationship with Lewy, amyloid-β and tau pathology. Associations were nominated in neuropathologically defined samples with Lewy body disease from the Netherlands Brain Bank (n = 217) and followed up in an independent sample series from the Mayo Clinic Brain Bank (n = 394). We also generated stratified polygenic risk scores based on single-nucleotide polymorphisms annotated to eight functional pathways or cell types previously implicated in Parkinson’s disease and assessed for association with Lewy pathology in subgroups with and without significant Alzheimer’s disease co-pathology.In an ordinal logistic regression model, the Alzheimer’s disease polygenic risk score was associated with concomitant amyloid-β and tau pathology in both cohorts. Moreover, both cohorts showed a significant association between lysosomal pathway polygenic risk and Lewy pathology, which was more consistent than the association with a general Parkinson’s disease risk score and specific to the subset of samples without significant concomitant Alzheimer’s disease related neuropathology.Our findings provide proof of principle that the specific risk alleles a patient carries for Parkinson’s and Alzheimer’s disease also influence key aspects of the underlying neuropathology in Lewy body disease. The interrelations between genetic architecture and neuropathology are complex, as our results implicate lysosomal risk loci specifically in the subset of samples without Alzheimer’s disease co-pathology. Our findings hold promise that genetic profiling may help predict the vulnerability to specific neuropathologies in Lewy body disease, with potential relevance for the further development of precision medicine in these disorders.
When local business faded away: the uneven impact of Airbnb on the geography of economic activities
Authors: Hidalgo Alberto , Riccaboni Massimo , Velazquez Francisco J 
Published: May 2023

Abstract
This paper investigates the unequal effect of Airbnb on the spatial organisation of economic activity in Madrid, Spain. Using establishment-level data from Madrid City Council and consumer-facing information from this short-term rental company, we find that Airbnb reshapes the urban space by encouraging tourist-oriented businesses, defined as businesses where tourists spend more than locals, at the expense of businesses primarily oriented to locals. These findings prove that short-term rentals do displace not only the local population but also resident-oriented businesses. Ultimately, our findings remain solid regardless of how we measure short-term rental activity and are not influenced by the growth of e-commerce or gentrification.
A case report of rapid diagnosis of atrial–oesophageal fistula by transthoracic echocardiogram with agitated saline injection
Authors: Galante Ori , Braiman Dana , Haim Moti , Kobal Sergio L 
Published: May 2023

Abstract

Background
Catheter ablation is a common treatment for atrial fibrillation (AF). Atrial–oesophageal fistula (AOF) is a rare yet fatal complication of catheter ablation. Chest computed tomography (CT) is the diagnostic modality of choice but may be undiagnostic in up to 24% of cases.

Case summary
We present the case of a 61-year-old male who presented with pleuritic chest pain, hypotension, fever, and coffee-ground emesis 20 days after cryoablation for AF. His chest CT was undiagnostic. Atrial–oesophageal fistula was diagnosed by injecting agitated saline into the nasogastric tube during a transthoracic echocardiogram (TTE) that showed bubbles in the left atrium and ventricle.

Discussion
In the case presented, as often happens, the diagnosis of AOF was delayed for several days, during which the patient presented with septic shock and concomitant multiorgan failure. The high mortality rate associated with AOF is partially attributable to delayed diagnosis. As prompt surgical intervention offers the best chance of survival, a high level of suspicion is of the utmost importance. We suggest contrast-enhanced TTE as a potential diagnostic tool when a rapid and definitive diagnosis is crucial and CT is inconclusive. Since this procedure is not without risk, proper risk consideration and management are necessary.
Three stakeholders’ reflections on language assessment literacy
Authors: Lee Jiyoon , Goldenberg Natalia , Williams Debby Pastrana 
Published: May 2023

Abstract
This reflective action research documents the mutual learning experiences of three education stakeholders as they construct their language assessment literacy (LAL). A teacher educator, an inservice teacher, and a preservice teacher were the three stakeholders who took part in a project on language assessment development for ESOL students at a public school in the United States. In this project, with the help of inservice ESOL teachers, preservice ESOL teachers designed and implemented listening and writing assessments for local middle school ESOL students. During and after the project, one of the participating inservice teachers, one preservice teacher, and the teacher educator voluntarily participated in extended reflective practices via email communications, on-site visits, and pre- and post-project discussions. All stakeholders perceived the collaboration as a mutual learning experience to enhance their LAL while sharing their respective expertise.