bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosome‐level genome assembly of the Asian citrus psyllid, Diaphorina citri
Authors: Lei Shuang , Yu Shi‐Jiang , Pan Qi , Ding Li‐Li , Li Si‐Chen , Cheng Lu‐Yan , Wang Shu‐Qi , Lou Bing‐Hai , He Jun , Lei Cui‐Yun , Cong Lin , Liu Hao‐Qiang , Wang Xue‐Feng , Ran Chun 
Published: May 2023

AbstractDiaphorina citri is a global citrus pest. As a vector insect, it can transmit the causative agents of citrus huanglongbing, causing irreversible losses to the citrus industry. The acquisition of genomic information can provide a molecular genetic basis for effective control of D. citri. Here, the DNBSEQ™, Oxford Nanopore Technologies, and Hi‐C technologies are applied to generate a high‐quality chromosome‐level genome of D. citri. The genome size of D. citri was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes. A total of 250.64 Mb (47.85%) repeat sequences and 24 048 protein‐coding genes were predicted. Genome resequencing of female and male individuals indicated that the sex chromosome system of D. citri is XO. Phylogenetic analysis demonstrated that D. citri and Pachypsylla venusta, which separated from their most recent common ancestor about 336.62 million years ago, were the most closely related. Additionally, we identified genes potentially involved in detoxification metabolism, pathogen transmission, and honeydew secretion for further investigation. The high‐quality genome provides an important reference for developing effective management strategies of D. citri.
Factors affecting presenteeism in workers with nocturnal hemodialysis: A two‐center cross‐sectional study
Authors: Yabe Hiroki , Tabata Aki , Sugimoto Norihisa , Saeki Tomohiro , Tsukada Takeshi , Mohara Jin 
Published: May 2023

AbstractIntroductionPresenteeism and work dysfunction in dialysis patients should be assessed to improve disease management and work productivity. Therefore, this study aimed to investigate the prevalence and factors surrounding presenteeism and work dysfunction in workers with nocturnal hemodialysis.MethodsThis multicenter cross‐sectional study included 42 workers with nocturnal hemodialysis. Presenteeism was measured in patients using the Work Functioning Impairment Scale (WFun), employment status, exercise habit, and exercise self‐efficacy (SE).ResultsThe WFun score was 12.5 ± 6.3 points, and patients with mild presenteeism were 12 (28.6%), moderate was 2 (4.8%), and severe was 1 (2.4%). Multiple regression analysis, which was adjusted for few confounding factors, showed that WFun had a significant relationship with lower exercise SE (r = −0.32) and normalized protein catabolism rate (r = 0.31).ConclusionsWorking patients with nocturnal hemodialysis had presenteeism and a significant correlation with exercise SE and nPCR. This study provides a framework to prevent work dysfunction in nocturnal hemodialysis patients.
A novel molecular mechanism mediated by circCCDC134 regulates non‐small cell lung cancer progression
Authors: Tong Zhufeng , Wang Zhen , Jiang Jinghan , Tong Chengcheng , Wu Lan 
Published: May 2023

AbstractBackgroundCircular RNA (circRNA) plays a crucial role in non‐small cell lung cancer (NSCLC) progression. However, the role of circCCDC134 in NSCLC is still largely unknown.MethodsQuantitative real‐time PCR was utilized for measuring circCCDC134, microRNA (miR)‐625‐5p and nuclear factor of activated T cell 5 (NFAT5) expression. Cell functions were evaluated by colony formation, EdU, transwell, and wound healing assays and flow cytometry. Glucose consumption, lactate production, and ATP level were determined to analyze cell glycolysis. Western blot analysis was used to detect protein expression. Animal experiments were performed to assess the effect of circCCDC134 on NSCLC tumor growth. RNA interaction was evaluated by dual‐luciferase reporter assay and RIP assay. Exosomes were isolated from the serum of NSCLC patients and healthy normal controls.ResultsHighly expressed circCCDC134 was found in NSCLC tissues and cells, as well as in the serum exosomes of NSCLC patients. Downregulated circCCDC134 restrained NSCLC cell growth, metastasis and glycolysis. CircCCDC134 sponged miR‐625‐5p to regulate NFAT5. MiR‐625‐5p inhibitor abolished the regulation of circCCDC134 knockdown on NSCLC progression, and NFAT5 overexpression eliminated the effects of miR‐625‐5p on NSCLC cell behaviors. CircCCDC134 knockdown also inhibited NSCLC tumor growth.ConclusionOur study revealed that circCCDC134 was involved in regulating NSCLC progression through the miR‐625‐5p/NFAT5 pathway, confirming that circCCDC134 might function as the diagnostic and therapeutic target for NSCLC.
Population pharmacokinetic and exposure‐response modelling to inform upadacitinib dose selection in adolescent and adult patients with atopic dermatitis
Authors: Ismail Mohamed , Doelger Eva , Eckert Doerthe , Irvine Alan D. , Chu Alvina D. , Teixeira Henrique D. , Liu Wei , Nader Ahmed 
Published: May 2023

AimsFirst, population pharmacokinetic analyses were used to characterize upadacitinib pharmacokinetics in adolescent and adult participants with atopic dermatitis (AD) and to identify patient covariates that may impact upadacitinib pharmacokinetics. Second, the exposure‐response relationship for upadacitinib with efficacy and safety endpoints, and the effect of age and concomitant use of topical corticosteroids (TCS) on the exposure‐response relationship and dose selection for patients with AD were evaluated.MethodsA two‐compartment model with combined first‐ and zero‐order absorption adequately characterized the upadacitinib concentration‐time profiles in 911 healthy volunteer adolescent and adult participants with AD who received upadacitinib 15 or 30 mg orally once daily (QD) as monotherapy or in combination with TCS for 16 weeks. Logistic regression models were developed to characterize the exposure‐efficacy and safety relationships, and simulations were performed based on final exposure‐response models to predict efficacy responses in participants with AD who received placebo or upadacitinib as monotherapy or in combination with TCS.ResultsUpadacitinib exposures were comparable between adolescents and adults. Mild or moderate renal impairment was predicted to increase the upadacitinib area under the plasma concentration‐time curve from time zero to 24 h after dosing (AUC24) approximately 12% and 25%, respectively, compared to participants with normal renal function. Female participants were predicted to have 20% higher AUC24 compared to male participants. Participants with AD were predicted to have 18% higher AUC24 compared to healthy participants. Simulated clinical efficacy responses showed added clinical efficacy benefit for all endpoints evaluated (8‐14%) with the upadacitinib 30 mg once‐daily regimen compared to 15 mg once‐daily in both age groups. In participants receiving upadacitinib in combination with TCS, significant exposure‐dependent increases in upadacitinib efficacy endpoints were observed. No significant effects of age or weight were identified in any of the exposure‐response models.ConclusionThe results of these analyses support the dose justification for upadacitinib in adult and adolescent patients with moderate to severe AD.
‘All of a sudden for no reason they've been displaced’: Constructing the ‘contingent refugee’ in early media reports on the Ukrainian refugees
Authors: Sambaraju Rahul , Shrikant Natasha 
Published: May 2023

AbstractThis paper analyzes descriptions of Ukrainian refugees in the aftermath of the Russian invasion of Ukraine. Findings of previous research on news media descriptions of refugees point to problematic descriptions of refugees that downgrade their deservingness of refuge and treat refugee status as an inherent feature of fleeing individuals instead of as contingent on external circumstances. However, there is a widespread perception that Ukrainian refugees are being reported on in a more positive light. We therefore examine how news media describe these refugees. Our corpus includes English media news coverage from February 25, 2022, to March 25, 2022, the initial period of the invasion. A discursive psychological analysis of news interactions where hosts elicit information from correspondents about current ongoings with Ukrainian refugees shows that Ukrainian refugees are constructed as vulnerable, and their actions are treated as reasonable given the situation. These descriptions construct Ukrainian refugees as those who are only contingently refugees and legitimate help‐giving by other parties. Our findings, therefore, highlight distinct, previously unanalyzed ways that refugees are constructed: contingent refugees. We discuss implications of our findings for understanding refugee inclusion and exclusion.
A cognitive balance approach to understanding intergroup attitudes in post‐Brexit Northern Ireland
Authors: Loughnane Jack , Roth Jenny , van Tilburg Wijnand 
Published: May 2023

AbstractCognitive balance theory posits that a drive for cognitively consistent thoughts modulates interpersonal relations. We extended cognitive balance theory to intergroup relations and tested it in a real‐life setting where intergroup relations are under strain: Northern Ireland in the wake of the UK's withdrawal from the EU. We predicted that when the groups of Irish people and British people in Northern Ireland are perceived as more compatible, intergroup bias would be lower than when groups are perceived as less compatible. We collected data of residents of Northern Ireland before the UK's official withdrawal from the EU (N = 604) and after (N = 350). As hypothesized, attitudes towards British people positively related to attitudes towards Irish people when participants perceived the groups as more compatible. We found the opposite relationship at low levels of perceived compatibility. Exploratory cross‐lagged panel analyses did not show that these effects occurred longitudinally, suggesting that cognitive balance does not drive judgements over time possibly because people are less likely to notice inconsistent responses across different time points. The present research demonstrates that intergroup attitudes assessed at a certain point in time follow cognitive balance principles.
Unravelling rift propagation from Cenozoic subsidence patterns: Examples from the Dangerous Grounds, South China Sea
Authors: Fang Penggao , Ding Weiwei , Wei Xiaodong , Zhao Yanghui 
Published: May 2023

AbstractHow seafloor spreading in marginal basins controls subsidence patterns in continental margins under rift propagation settings remains poorly understood. Herein, based on detailed geological interpretation and backstripping of 37 high‐resolution multichannel seismic reflection sections, we calculate the Cenozoic tectonic subsidence across the Dangerous Grounds (DG), South China Sea, in order to study interactions between seafloor spreading and the propagation of rift basins. Our results show that rapid subsidence occurred in the eastern Dangerous Grounds (EDG) from the Palaeocene to early Oligocene, then migrated westwards to the middle Dangerous Grounds (MDG) during the early Oligocene to early Miocene, and finally reached the western Dangerous Grounds (WDG) during the early to middle Miocene. We interpret this western migration of intensive subsidence as the response of the inherited pre‐Cenozoic heterogeneous lithospheric structure of South China. Thermal re‐equilibration of the lithosphere then dominated the rapid post‐spreading subsidence throughout the whole DG from the middle Miocene. An anomalous subsidence deficit occurred in the EDG during the early Oligocene to early Miocene, and in the MDG during the early to middle Miocene; this phenomenon might be related to small‐scale mantle convection associated with the propagation of seafloor spreading from east to southwest.
Assessment of joint bleeding and target joints in patients with severe or moderately severe hemophilia B (factor IX ≤2%) receiving prophylaxis with rIX‐FP in the PROLONG‐9FP clinical trial program
Authors: Laws Hans‐Juergen , Fukutake Katsuyuki , Lopez‐Fernandez Maria Fernanda , Li Yanyan , Seifert Wilfried , Tagliaferri Annarita 
Published: May 2023

AbstractObjectiveTo assess the impact of prophylaxis with rIX‐FP, a fusion protein linking recombinant factor IX (FIX) with human albumin, on joint outcomes.MethodsJoint outcomes were assessed in pediatric (<12 years) and adult/adolescent (≥12 years) patients receiving rIX‐FP prophylaxis every 7, 10, or 14 days; patients (>18 years) well‐controlled on a 14‐day regimen could switch to a 21‐day regimen. Target joints were defined as ≥3 spontaneous bleeds into a single joint within a 6‐month period.ResultsFor adult/adolescent (n = 63) and pediatric (n = 27) patients, median (Q1, Q3) annualized joint bleeding rate was 0.39 (0.00, 2.31), 0.80 (0.00, 2.85), 0.20 (0.00, 2.58), and 0.00 (0.00, 1.78) when treated with 7‐, 10‐, 14‐, or 21‐day prophylaxis. 50.0%, 38.9%, 45.5%, and 63.6% of adult/adolescent patients had no joint bleeds when treated with 7‐, 10‐, 14‐, or 21‐day prophylaxis, respectively, and 40.7%, 37.5%, and 37.5% of pediatric patients had no joint bleeds when treated with 7‐, 10‐, or 14‐day prophylaxis. Ten adult and two pediatric patients developed target joints; all resolved by the end of the study.ConclusionProphylaxis with rIX‐FP produced low joint bleeding rates and provided excellent hemostatic efficacy in the treatment of joint bleeds. All target joints reported resolved with rIX‐FP prophylaxis.
Long‐term follow‐up of 64 children with classical infantile‐onset Pompe disease since 2004: A French real‐life observational study
Authors: Tardieu Marine , Cudejko Céline , Cano Aline , Hoebeke Célia , Bernoux Delphine , Goetz Violette , Pichard Samia , Brassier Anaïs , Schiff Manuel , Feillet François , Rollier Paul , Mention Karine , Dobbelaere Dries , Fouilhoux Alain , Espil‐Taris Caroline , Eyer Didier , Huet Frédéric , Walther‐Louvier Ulrike , Barth Magalie , Chevret Laurent , Kuster Alice , Lefranc Jérémie , Neveu Julien , Pitelet Gaele , Ropars Juliette , Rivier François , Roubertie Agathe , Touati Guy , Vanhulle Catherine , Tardieu Emilie , Caillaud Catherine , Froissart Roseline , Champeaux Murielle , Labarthe François , Chabrol Brigitte 
Published: May 2023

AbstractBackgroundClassical infantile‐onset Pompe disease (IOPD) is the most severe form of Pompe disease. Enzyme replacement therapy (ERT) has significantly increased survival but only a few studies have reported long‐term outcomes.MethodsWe retrospectively analyzed the outcomes of classical IOPD patients diagnosed in France between 2004 and 2020.ResultsSixty‐four patients were identified. At diagnosis (median age 4 months) all patients had cardiomyopathy and most had severe hypotonia (57 of 62 patients, 92%). ERT was initiated in 50 (78%) patients and stopped later due to being ineffective in 10 (21%). Thirty‐seven (58%) patients died during follow‐up, including all untreated and discontinued ERT patients, and 13 additional patients. Mortality was higher during the first 3 years of life and after the age of 12 years. Persistence of cardiomyopathy during follow‐up and/or the presence of heart failure were highly associated with an increased risk of death. In contrast, cross‐reactive immunologic material (CRIM)‐negative status (n = 16, 26%) was unrelated to increased mortality, presumably because immunomodulation protocols prevent the emergence of high antibody titers to ERT. Besides survival, decreased ERT efficacy appeared after the age of 6 years, with a progressive decline in motor and pulmonary functions for most survivors.ConclusionsThis study reports the long‐term follow‐up of one of the largest cohorts of classical IOPD patients and demonstrates high long‐term mortality and morbidity rates with a secondary decline in muscular and respiratory functions. This decreased efficacy seems to be multifactorial, highlighting the importance of developing new therapeutic approaches targeting various aspects of pathogenesis.
Globus pallidus internus versus subthalamic nucleus deep brain stimulation for isolated dystonia: A 3‐year follow‐up
Authors: Lin Suzhen , Shu Yimei , Zhang Chencheng , Wang Lingbing , Huang Peng , Pan Yixin , Ding Jianqing , Sun Bomin , Li Dianyou , Wu Yiwen 
Published: May 2023

AbstractBackground and purposeBilateral deep brain stimulation (DBS) surgery targeting the globus pallidus internus (GPi) or the subthalamic nucleus (STN) is widely used in medication‐refractory dystonia. However, evidence regarding target selection considering various symptoms remains limited. This study aimed to compare the effectiveness of these two targets in patients with isolated dystonia.MethodsThis retrospective study evaluated 71 consecutive patients (GPi‐DBS group, n = 32; STN‐DBS group, n = 39) with isolated dystonia. Burke–Fahn–Marsden Dystonia Rating Scale scores and quality of life were evaluated preoperatively and at 1, 6, 12, and 36 months postoperatively. Cognition and mental status were assessed preoperatively and at 36 months postoperatively.ResultsTargeting the STN (STN‐DBS) yielded effects within 1 month (65% vs. 44%; p = 0.0076) and was superior at 1 year (70% vs. 51%; p = 0.0112) and 3 years (74% vs. 59%; p = 0.0138). For individual symptoms, STN‐DBS was preferable for eye involvement (81% vs. 56%; p = 0.0255), whereas targeting the GPi (GPi‐DBS) was better for axis symptoms, especially for the trunk (82% vs. 94%; p = 0.015). STN‐DBS was also favorable for generalized dystonia at 36‐month follow‐up (p = 0.04) and required less electrical energy (p < 0.0001). Disability, quality of life, and depression and anxiety measures were also improved. Neither target influenced cognition.ConclusionsWe demonstrated that the GPi and STN are safe and effective targets for isolated dystonia. The STN has the benefits of fast action and low battery consumption, and is superior for ocular dystonia and generalized dystonia, while the GPi is better for trunk involvement. These findings may offer guidance for future DBS target selection for different types of dystonia.
Impact of weight gain with dolutegravir on antiretroviral adherence and viral suppression in four African countries
Authors: Romo Matthew L. , Esber Allahna L. , Owuoth John , Maswai Jonah , Sing'oei Valentine , Iroezindu Michael , Bahemana Emmanuel , Kibuuka Hannah , Cavanaugh J. Sean , Shah Neha , Ake Julie A. , Crowell Trevor A. ,   the AFRICOS Study Group
Published: May 2023

AbstractObjectiveWe hypothesized that total body weight (TBW) gain after switching antiretroviral therapy (ART) regimen to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) may negatively impact ART adherence and viral load (VL) and therefore sought to examine these associations.MethodsThe ongoing African Cohort Study (AFRICOS) enrols people with HIV at 12 facilities in Kenya, Nigeria, Tanzania and Uganda supported by The US President's Emergency Plan for AIDS Relief. Among ART‐experienced participants who switched to TLD, we used multivariable multinomial logistic regression to examine associations between pre−/post‐TLD changes in percentage TBW (≥5% gain, <5% change, ≥5% loss) and changes in self‐reported ART adherence (0, 1–2, ≥3 days missed doses in past 30 days) and VL [(<50 copies/mL (undetectable), 50–999 copies/mL (detectable, but suppressed), ≥1000 copies/mL (unsuppressed)].ResultsAmong 1508 participants, median time from starting TLD to follow‐up was 9 months (interquartile range: 7–11). Overall, 438 (29.1%) participants experienced a TBW gain ≥5%, which was more common among females than among males (32.2% vs 25.2%, p = 0.005) and participants switching from efavirenz [32.0% vs nevirapine (19.9%) and boosted protease inhibitor (20.0%); p < 0.001]. Compared with a TBW change <5% [950 (63.0%) participants], TBW gain ≥5% was not significantly associated with more days with missed ART doses [adjusted odds ratio (aOR) = 0.77, 95% confidence interval (CI): 0.48–1.23] or VL becoming detectable and/or unsuppressed (aOR = 0.69, 95% CI: 0.41–1.16).ConclusionsAlthough a substantial proportion of participants experienced weight gain after switching to TLD, we did not identify a significant impact on adherence or virological outcomes.
The effect of Salix alba L. bark extract on dark circles in vitro and in vivo
Authors: Jeon Suwon , Yoon Sohyun , Kim Yuna , Shin Seoungwoo , Ji Hyanggi , Cho Eunae , Park Deokhoon , Jung Eunsun 
Published: May 2023

AbstractObjectiveDark circles in the infraorbital area are a common cosmetic concern among individuals because they exhibit fatigue and are undesirable across all ages. Of the dark circle etiologies, blood stasis by poor‐vascular integrity can cause darkening of the lower eyelid skin, which might be alleviated by reduced endothelial permeability. In this study, we investigated the effects of Salix alba bark extract (SABE) on the synthesis of hyaluronic acid (HA) in fibroblasts and vascular integrity protection from inflammatory cytokine. We also performed a clinical trial investigating the effect of SABE on dark circles.MethodsTo confirm the effect of SABE on HA synthesis in human dermal fibroblasts (HDFs), we performed ELISA and real‐time PCR. We investigated the interaction HDF‐secreted substance with vascular integrity, and human dermal microvascular endothelial cells (HMEC‐1) were treated with conditioned medium (CM) from HDF treated with or without SABE. Subsequently, we conducted a clinical study on 29 subjects by having them apply SABE containing cream for 8 weeks.ResultsSalix alba bark extract treatment increased HA synthesis and regulated HMW–HA‐related gene expressions in HDF. CM from SABE‐treated HDF alleviated endothelial permeability and led to improved vascular integrity in HMEC‐1 cells. Treatment with the cream containing 2% SABE for 8 weeks improved the parameters measuring dark circles, skin microcirculation and elasticity.ConclusionOur results showed that SABE could protect against dark circles in vitro, and that topical treatment of SABE improved the clinical indexes of dark circles in a clinical study. Therefore, SABE can be used as an active ingredient for improving dark circles.
Thirty years of International Transactions in Operational Research: past, present, and future direction
Authors: Akpan Ikpe Justice 
Published: May 2023

AbstractThe journal “International Transactions in Operational Research” (ITOR) marks its 30th anniversary this year. This study undertakes the first bibliometrics analysis of ITOR covering the past 30 years (1994–2023). Utilizing metadata from 1835 articles published in the journal, this article evaluates ITOR’s intellectual, conceptual, and social structures. The study highlights several exciting outcomes: First, the literature publication trend shows sustained growth and increased articles’ publication and citation impacts. Second, the analysis of the intellectual structure using co‐citation analysis and text analytics identified a solid collaborative relationship with core sources in operations research and management science and applications. Third, the conceptual evaluation using the co‐occurrence of keywords as the unit of analysis identifies the thematic trends of publications in ITOR. Finally, the social structures, which focused on country collaborations and literature contributions dynamics and impacts, offer insights into future directions to maintaining or strategizing a global focus for the Journal.