bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel signature of aging-related genes associated with lymphatic metastasis for survival prediction in patients with bladder cancer
Authors: Zhu Zhiguo , Li Xiaoli , Liu Deqian , Li Zhonghai 
Published: June 2023

BackgroundThe predominant and most prevalent form of metastatic bladder cancer (BCa) is lymphatic metastasis, which is associated with a highly dismal prognosis for patients. Aging-related genes (ARGs) are believed to contribute significantly to tumor development. However, the effect of ARGs on lymphatic metastasis of BCa is unclear. This research sought to establish a prognosis model based on ARGs associated with lymphatic metastasis in BCa.MethodsWe downloaded BCa data from the TCGA and GEO databases and ARGs from the Aging Atlas database. The least absolute shrinkage and selection operator (LASSO) approach was applied to obtain the characteristic ARGs of risk signature in the TCGA cohort. Verification was done using the GSE13507 dataset. The R package ‘ConsensusClusterPlus’ was employed to identify the molecular subtypes based on the characteristic ARGs. Protein-Protein interaction network, MCODE analysis, enrichment analysis (KEGG, GO, GSEA), and immune infiltration analysis were performed to investigate underlying mechanisms. EdU, migration and invasion assays, wound healing assays, immunofluorescence staining, and quantitative polymerase chain reaction were conducted to evaluate the impact of ELN on the proliferative, migratory, and invasive capacities of BCa cells.ResultsWe identified 20 differently expressed ARGs. A four ARGs risk signature (EFEMP1, UCHL1, TP63, ELN) was constructed in the TCGA cohort. The high-risk group (category) recorded a reduced overall survival (OS) rate relative to the low-risk category (hazard ratio, 2.15; P &lt;0.001). The risk score could predict lymphatic metastasis in TCGA cohort (AUC=0.67). The GSE13507 dataset was employed to verify the validity of this risk score. Based on the four ARGs, two distinct aging profiles (Cluster 1 and Cluster 2) were discovered utilizing the ConsensusClusterPlus, and Cluster 2 possessed a favorable OS in contrast with Cluster 1 (hazard ratio, 0.69; P =0.02). Classical tumor signaling pathways, ECM-associated signaling pathways, and immune-related signaling pathways participate in BCa progression. ELN recombinant protein affected the expression of collagen and increased migration and invasiveness in BCa cells.ConclusionWe constructed a four-ARG risk signature and identified two aging molecular subtypes. This signature could serve as an effective survival predictor for patients with BCa.
Pathologic response and survival after neoadjuvant chemotherapy with or without pertuzumab in patients with HER2-positive breast cancer: the Neopearl nationwide collaborative study
Authors: Fabbri Agnese , Nelli Fabrizio , Botticelli Andrea , Giannarelli Diana , Marrucci Eleonora , Fiore Cristina , Virtuoso Antonella , Scagnoli Simone , Pisegna Simona , Alesini Daniele , Sini Valentina , Orlandi Armando , Fabi Alessandra , Piacentini Federico , Moscetti Luca , D’Auria Giuliana , Gamucci Teresa , Mazzotta Marco , Pizzuti Laura , Vici Patrizia , Cretella Elisabetta , Scavina Paola , La Cesa Annalisa , Persano Mara , Atzori Francesco , Ruggeri Enzo Maria 
Published: June 2023

PurposeClinical trials have shown a significant increase in pathologic complete response (pCR) with the addition of pertuzumab to neoadjuvant chemotherapy for patients with early-stage HER-2 positive breast cancer. To date, limited studies have examined comparative outcomes of neoadjuvant pertuzumab in real-world setting. The Neopearl study aimed to assess comparative real-life efficacy and safety of neoadjuvant pertuzumab for these patients.MethodsWe conducted a nationwide retrospective analysis involving 17 oncology facilities with a certified multidisciplinary breast cancer treatment committee. We identified patients with HER-2 positive stage II-III breast cancer treated with neoadjuvant chemotherapy based on trastuzumab and taxanes with or without pertuzumab. All patients underwent breast surgery and received a comprehensive cardiologic evaluation at baseline and after neoadjuvant treatment. Patients who received the combination of pertuzumab, trastuzumab, and chemotherapy constituted case cohort (PTCT), whereas those treated with trastuzumab and chemotherapy accounted for control cohort (TCT). The pCR rate and 5-year event free survival (EFS) were the primary outcomes. Secondary end-points were rates of conversion from planned modified radical mastectomy (MRM) to breast conservation surgery (BCS) and cardiotoxicities.ResultsFrom March 2014 to April 2021, we included 271 patients, 134 (49%) and 137 (51%) in TCT and PTCT cohort, respectively. Positive axillary lymph nodes and stage III were more frequent in PTCT cohort. The pCR rate was significantly increased in patients who received pertuzumab (49% vs 62%; OR 1.74, 95%CI 1.04-2.89) and with HER-2 enriched subtypes (16% vs 85%; OR 2.94, 95%CI 1.60-5.41). After a median follow-up of 5 years, the 5-year EFS was significantly prolonged only in patients treated with pertuzumab (81% vs 93%; HR 2.22, 95%CI 1.03-4.79). The same analysis performed on propensity score matched population showed concordant results. On univariate analysis, only patients with positive lymph nodes were found to benefit from pertuzumab for both pCR and 5-year EFS. The rates of conversion from MRM to BCS and cardiologic toxicities did not differ between the cohorts.ConclusionOur findings support previous data on improved outcomes with the addition of pertuzumab to trastuzumab-based neoadjuvant chemotherapy. This benefit seems to be more significant in patients with clinically positive lymph nodes.
Clinical characteristics and correlation analysis of IVIG resistance in children with kawasaki disease complicated with hip synovitis: case-control study
Authors: Wang Jianjie , Rong Xing , Qiu Huixian , He Yue'e , Chu Maoping , Wang Zhenquan 
Published: June 2023

ObjectiveTo investigate the clinical characteristics and risk factors of Kawasaki disease (KD) complicated with hip synovitis.MethodsChildren with KD admitted from January 1, 2011, to December 31, 2020, in the KD database of Yuying Children's Hospital Affiliated with Wenzhou Medical University were retrospectively included. We selected KD children with hip synovitis as the case group and KD children without hip synovitis as the control group to analyze the possible risk factors of hip synovitis in KD children.ResultsAmong 2,871 KD children admitted to our center in recent years, 28 had hip synovitis. In this study 140 KD children were enrolled, including 28 KD children with hip synovitis and 112 children with general KD (within one month of admission). The onset age of KD patients with hip synovitis was 30.92 (23.23–49.99) months, and there were 17 cases of bilateral hip involvement. The course of synovitis (limited movement, joint pain, lameness, unwillingness to stand, etc.) ranged from 1 to 19 days, with an average of (8.8 ± 4.6) days. We treated all KD children with IVIG (Intravenous immunoglobulin) plus aspirin, among which five patients in the case group developed coronary artery damage, six acquired IVIG resistance, and synovial inflammation disappeared within two weeks. Age, weight, length of stay, and incidence of IVIG resistance significantly differed between the two groups (P = 0.001, 0.005, &lt;0.001, and 0.035, respectively). Logistic regression analysis showed that KD combined with hip synovitis was an independent risk factor for developing propyl pellet resistance, with an OR value of 4.625 (95% CI: 1.095, 19.526).ConclusionKD combined with hip synovitis mainly involves bilateral hip joints, and joint pain and limited movement are the main clinical features. The symptoms are mild and self-limiting. KD combined with hip synovitis is a risk factor for IVIG resistance. Hip synovitis is a good predictor of IVIG resistance.
Development of an APPLE III undulator prototype with three-dimensional force compensation for SHINE
Authors: Yu Cheng , Zhu Ya , Zhang Wei , Yang Jie , He Yongzhou , Zhen Tingting , Liu Tao , Lei Yangyang , Yuan Qibing , Yuan Dao , Wen Yongmei , Deng Rongbing , Jiang Zhiqiang , Deng Haixiao , Liu Bo , Wang Dong 
Published: June 2023

The Shanghai high-repetition-rate XFEL and extreme light facility (SHINE) plans to install several elliptically polarizing undulators (EPUs) as afterburners behind the planar undulator section to obtain nearly saturated circularly polarized free-electron laser (FEL) radiation. Therefore, the SHINE R&amp;D project needs to develop a 4-m-long EPU with an effective magnetic field of 1.5 T, a period of 68 mm, and a minimum gap of 3 mm. A magnetic force compensation EPU prototype has recently been built and tested at the Shanghai Synchrotron Radiation Facility (SSRF) based on the addition of permanent magnets. This prototype can realize magnetic compensation under various polarization modes in all working gaps, thereby reducing the deformation of the girders and maintaining sufficient rigidity of the mechanical structure. A girder deformation monitoring system was established to obtain real force compensation feedback. The final magnetic field measurement results meet the physical requirements, and the proposed scheme can be used as an alternative to the EPU with a high magnetic field and large magnetic force.
The relationship between teacher support and positive emotions in Chinese higher vocational students: multiple mediating effects of procrastination behavior and interpersonal assistance
Authors: Wang Junhui , Zhou Cheng , Song Qiming , Xu Fuxiao 
Published: June 2023

BackgroundIn China, more than 5 million students enter higher vocational colleges each year, and the positive emotions of their students merits much attention.PurposeThis study aimed to explore the effect of teacher support on positive emotions among higher vocational students by further investigating the mediating role of procrastination behavior and interpersonal assistance.MethodsA questionnaire survey was conducted with 676 higher vocational students from Zhejiang Province, China. We used SPSS 26.0 for data analysis, which included correlation analysis, regression analysis and bootstrap-mediated effects tests.ResultsTeacher support positively predicted positive emotions (β = 0.302, p &lt; 0.001) and interpersonal assistance (β = 0.170, p &lt; 0.001), while procrastination behavior negatively predicted interpersonal assistance (β = −0.161, p &lt; 0.001) and positive emotions (β = −0.088, p &lt; 0.01). Interpersonal assistance positively predicted positive emotions (β = 0.279, p &lt; 0.001). This study found that teacher support positively predicted positive emotions; either procrastination behavior or interpersonal assistance independently mediated the relationship between teacher support and positive emotions. These two variables (procrastination and interpersonal assistance) also acted as a chain mediator between teacher support and positive emotions. The direct effect of teacher support and the mediating role of interpersonal assistance had a greater effect.ConclusionThe study deeply explored the effects of teacher support on positive emotions among Chinese higher vocational students and found that teacher support plays an important role in positive emotion management. At the same time, we found the key roles played by procrastination behavior and interpersonal assistance between teacher support and positive emotion, which could provide data support and decision-making reference for enhancing higher education students’ well-being and positive emotions. This study can be regarded as a case study of social support theory and demonstrates the applicability of the theory in the field of positive emotions of higher vocational students.
Medical student attitudes and perceptions of psychedelic-assisted therapies
Authors: Li Irene , Fong Rodney , Hagen Molly , Tabaac Burton 
Published: June 2023

IntroductionAlthough certain psychedelic agents may soon gain federal approval for use in treating specific psychiatric conditions, the utilization of such therapies in clinical practice will depend largely on the attitudes of healthcare providers. Therefore, this study assesses the current attitudes, knowledge, exposure, and acceptance of psychedelics and psychedelic-assisted therapies amongst medical students.MethodsIn fall semester of 2022, surveys were emailed to 580 medical students attending medical institutions in the state of Nevada in the United States. Utilizing knowledge and attitude items from previously published studies, the survey collected demographic data and assessed student attitudes with five-point Likert-scale variables. Data was analyzed using summary statistics and Kruskal-Wallis tests for differences in mean survey scores (i.e., attitudes towards psychedelics) based on demographic factors.Results132 medical students participated in the survey (22.7% response rate). Medical students demonstrated overall positive attitudes towards psychedelics, lack of knowledge regarding psychedelics, and uncertainty towards neurocognitive risks of psychedelics. Overall, 78.6% of students agreed that psychedelics have therapeutic potential, while 95.2% agreed that psychedelics deserves further research in assessing this potential. Additionally, there was no statistically significant effect of demographic variables, including age, sex, and level of training, on attitudes.DiscussionAlthough students are overall curious and optimistic about psychedelics, they demonstrate a lack of knowledge regarding recent research efforts. As the field of psychiatry prepares to implement psychedelics and psychedelic-assisted therapies, education and awareness of such agents should be initiated early on in medical clinical training.
Life satisfaction, positive affect, depression and anxiety symptoms, and their relationship with sociodemographic, psychosocial, and clinical variables in a general elderly population sample from Chile
Authors: Saldivia Sandra , Aslan Joseph , Cova Félix , Bustos Claudio , Inostroza Carolina , Castillo-Carreño Anabel 
Published: June 2023

BackgroundThis study aims to describe the relationship between life satisfaction, positive affect, depression and anxiety symptoms with sociodemographic, psychosocial and clinical variables, and to identify the relative importance of these predictor groups.MethodsWe evaluated life satisfaction (SWLS), positive affect (PANAS), depressive (PHQ-9), and anxiety (GAI) symptoms and their association with sociodemographic, psychosocial and clinical variables in a multistage, random general population sample of fully functioning individuals aged 60–80 years from the Concepción province and Gran Santiago, Chile (n = 396). We performed weighted multiple regression analysis, considering the complex sample structure with age group, sex, and geographical area, complemented with general and conditional dominance analyses to estimate the relevance of the predictor groups.ResultsWe found significant associations with the geographical area, sex, age, education level, household members, having a partner, employment status, caregiver status, economic satisfaction, presence of chronic diseases, medication use, and alcohol use. Satisfaction with health was the most important predictor for positive affect (p &lt; 0.001), depressive (p &lt; 0.001), and anxiety (p &lt; 0.001) symptoms, while alcohol use was the most significant predictor for life satisfaction (p &lt; 0.001).ConclusionSimultaneously studying the positive and negative dimensions of wellbeing and mental health in older adults allows for a more comprehensive perspective on the challenges faced during this stage of life. This study accounts for previously unknown associations and contributes to the identification of common and specific predictors in both dimensions.
A study of the types and manifestations of physicians' unintended behaviors in the DRG payment system
Authors: Chang Wei-Fu , Yan Xin-Yu , Ling Hao , Liu Ting , Luo Ai-Jing 
Published: June 2023

IntroductionIn recent years, China has implemented the Diagnosis Related Groups (DRG) payment system as part of its healthcare insurance reimbursement policy. Numerous studies have focused on the effectiveness of DRG payment system in controlling unreasonable growth in medical expenses. However, there has been no systematic report on the types of unintended behaviors exhibited by doctors under the DRG payment system.MethodsThe study first utilized interrupted time series analysis to analyze medical records and insurance data from eight hospitals. It investigated the data changes in MDC and ADRG groups before and after the implementation of the DRG payment system. Subsequently, a semi-structured interview method was employed to conduct qualitative research on the unintended behaviors of physicians, aiming to gain a more accurate understanding of specific changes in physician behavior after the implementation of the DRG payment system.ResultsThis study discovered that doctors engage in unintended behaviors within the framework of the DRG payment system.DiscussionIn the early implementation of the DRG payment system in China, the contradictions between the flawed DRG payment methods and supporting systems and the actual diagnostic and treatment work manifested in the form of unintended doctor behaviors. Most of these unintended behaviors can be considered reasonable feedback from doctors to cope with the existing system flaws. They are conducive to identifying the deficiencies in China's DRG payment system and suggesting directions for improvement.
Depression, anxiety and insomnia in Chinese older adults and their family caregivers during the COVID-19 pandemic: an actor-partner interdependence model approach
Authors: Ding Kai-Rong , Xu Wen-Qi , He Yong-Yi , Hu Jia-Hui , Tan Wen-Yan , Liao Jing , Hou Cai-Lan , Jia Fu-Jun , Wang Shi-Bin 
Published: June 2023

AimsThis study aimed to explore the dyadic effects of depression and anxiety on insomnia symptoms in Chinese older adults and their caregivers living in a community setting.MethodsData were collected from 1,507 pairs of older adults and their caregivers who were in the Guangdong Mental Health Survey in China. The 9-item Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder module 7 (GAD-7), and Insomnia Severity Index (ISI) were used to measure depression, anxiety, and insomnia symptoms. Actor-Partner Interdependence Models (APIM) were used to determine whether anxiety or depression symptoms predicted individual or dyadic insomnia.ResultsOlder adults' and caregivers' depression and anxiety had significant positive correlations with their own and their caregivers' insomnia symptoms (all P &lt; 0.001). Actor effects were found between depression and insomnia symptoms in both older adults and caregivers (B = 0.695, P &lt; 0.001; B = 0.547, P &lt; 0.001, respectively), with one significant partner effects (B = 0.080, P = 0.007). Actor effects were also found between anxiety and insomnia symptoms in both older adults and caregivers (B = 0.825, P &lt; 0.001; B = 0.751, P &lt; 0.001, respectively), with one significant partner effects (B = 0.097, P = 0.004). However, the caregivers' depression and anxiety were not associated with older adults' insomnia symptoms in the APIM analyses.ConclusionsOlder adults and their caregivers had an interrelationship between psychological distress and insomnia. Consequently, healthcare providers might consider involving dyads when designing programs to reduce insomnia and improve psychological distress for family caregivers.
The influence of neighborhood built environment on school-age children’s outdoor leisure activities and obesity: a case study of Shanghai central city in China
Authors: Tan Weifan , Lu Xiaocong , Xiao Tingting 
Published: June 2023

ObjectiveThe aim of this study was to examine the influencing pathways of the neighborhood built environment on children’s outdoor leisure activities and obesity.MethodsA total of 378 elementary school students from 10 schools in central Shanghai were selected by a convenient sampling method for questionnaire survey and accelerometer tracking.Results1) The neighborhood built environment could affect children’s obesity not only through direct effect (β = 0.15, p &lt; 0.05), but also through the mediating effect of outdoor leisure activities (β = 0.19, p &lt; 0.05). 2) For boys, the neighborhood built environment could affect children’s obesity not only through direct effect (β = 0.17, p &lt; 0.05), but also through the mediating effect of outdoor leisure activities (β = 0.26, p &lt; 0.05). For girls, the neighborhood built environment could affect children’s obesity only through the mediating effect of outdoor leisure activities (β = 0.13, p &lt; 0.05).ConclusionThe neighborhood built environment and outdoor leisure activities are important influencing factors in children’s obesity. The neighborhood built environment and outdoor leisure activities could have direct and indirect effects on children’s obesity, while there are gender differences in the influencing pathways of the neighborhood built environment on children’s obesity. This study suggests that improving the neighborhood built environment and promoting outdoor leisure activities in children have important value for influencing children’s obesity.
Knowledge, attitude, and practice toward COVID-19 transmission, prevention, and self-quarantine management among public servants in selected locations of the Sidama region, Southern Ethiopia: a multicenter cross-sectional study
Authors: Borie Yacob Abraham , Yeheyis Tomas , Deribe Bedilu , Ayalew Mohammed , Reta Yared , Hoyiso Dawit , Jembere Wegene 
Published: June 2023

BackgroundThe COVID-19 epidemic has put an enormous strain on the world’s healthcare systems, lifestyles, and quality of life. Ethiopia attempted to meet the myriad needs of its people due to the COVID-19 epidemic and the government has demonstrated a strong commitment in order to lessen the epidemic’s impact on the populace. Despite this fact, the population’s compliance with measures was not as needed.ObjectivesTo assess knowledge, attitude, and practice regarding COVID-19 transmission, prevention, and self-quarantine management among public employees in selected locations of the Sidama Region, Southern Ethiopia, in 2020.MethodsAn institution-based cross-sectional study was conducted from 01 October to 30 October 2020, among 399 public servants in selected locations of the Sidama Region, Sothern Ethiopia. One-stage cluster sampling was used to randomly select 16 public service sector offices from the total 32 sector offices in the selected locations of the region. Simple random sampling was employed to select respondents following equal distribution of the samples to 16 sector offices. Data were collected using an adapted self-administered questionnaire. Data entered using EpiData version 3.1 and SPSS version 24 were used for statistical analysis. Descriptive statistics was used to compute frequencies, percentages, and means for independent and dependent variables.ResultOverall, 42.36% of respondents had good knowledge of COVID-19, while the remaining 57.64% had poor knowledge. The percentage of favorable attitudes toward COVID-19 prevention and control were 65.2, 54.4% of respondents had a good level of practice of COVID-19 preventive and control measures, and 52.4% of the respondents had a good level of knowledge regarding self-quarantine management.ConclusionThe level of knowledge, attitude, practice, and self-quarantine management in the area is insufficient for preventing and controlling the disease. Evidence-based awareness creation and law enforcement in the study areas and surroundings, with an emphasis on infection prevention and control (IPC) in the public sector and other public gathering areas, is recommended.