bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and immune features of cuproptosis-related molecular clusters in polycystic ovary syndrome
Authors: Su Zhe , Su Wenjing , Li Chenglong , Ding Peihui , Wang Yanlin 
Published: January 2023

AbstractPolycystic ovary syndrome (PCOS), a common reproductive endocrine disease, has clinically heterogeneous characteristics. Recently, cuproptosis causes several diseases by killing cells. Hence, we aimed to explore cuproptosis-related molecular clusters in PCOS and construct a prediction model. Based on the GSE5090, GSE43264, GSE98421, and GSE124226 datasets, an analysis of cuproptosis regulators and immune features in PCOS was conducted. In 25 cases of PCOS, the molecular clusters of cuproptosis-related genes and the immune cell infiltration associated with PCOS were investigated. Weighted gene co-expression network analysis was used to identify differentially expressed genes within clusters. Next, we compared the performance of the random forest model, support vector machine model, generalized linear model, and eXtreme Gradient Boosting for deciding the optimum machine model. Validation of the predictive effectiveness was accomplished through nomogram, calibration curve, decision curve analysis, and using other two datasets. PCOS and non-PCOS controls differed in the dysregulation of cuproptosis-related genes and the activation of immunoreaction. Two cuproptosis-related molecular clusters associated with PCOS were identified. Significant heterogeneity was noted in immunity between the two clusters based on the analysis of immune infiltration. The immune-related pathways related to cluster-specific differentially expressed genes in Cluster1 were revealed by functional analysis. With a relatively low residual error and root mean square error and a higher area under the curve (1.000), the support vector machine model demonstrated optimal discriminative performance. An ultimate 5-gene-based support vector machine model was noted to perform satisfactorily in the other two validation datasets (area under the curve = 1.000 for both). Moreover, the nomogram, calibration curve, and decision curve analysis showed that PCOS subtypes can be accurately predicted. Our study results helped demonstrate a comprehensive understanding of the complex relationship between cuproptosis and PCOS and establish a promising prediction model for assessing the risk of cuproptosis in patients with PCOS.
An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
Authors: Lobb Richard J. , Visan Kekoolani S. , Wu Li-Ying , Norris Emma L. , Hastie Marcus L. , Everitt Sarah , Yang Ian A. , Bowman Rayleen V. , Siva Shankar , Larsen Jill E. , Gorman Jeffrey J. , MacManus Michael , Leimgruber Antoine , Fong Kwun M. , Möller Andreas 
Published: January 2023

AbstractDespite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide1. Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of only 10–20%. Currently, TNM staging is the gold standard for predicting overall survival and selecting optimal initial treatment options for NSCLC patients, including those with curable stages of disease. However, many patients with locoregionally-confined NSCLC relapse and die despite curative-intent interventions, indicating a need for intensified, individualised therapies. Epithelial-to-mesenchymal transition (EMT), the phenotypic depolarisation of epithelial cells to elongated, mesenchymal cells, is associated with metastatic and treatment-refractive cancer. We demonstrate here that EMT-induced protein changes in small extracellular vesicles are detectable in NSCLC patients and have prognostic significance. Overall, this work describes a novel prognostic biomarker signature that identifies potentially-curable NSCLC patients at risk of developing metastatic NSCLC, thereby enabling implementation of personalised treatment decisions.
Genetic analyses implicate complex links between adult testosterone levels and health and disease
Authors: Leinonen Jaakko T. , Mars Nina , Lehtonen Leevi E. , Ahola-Olli Ari , Ruotsalainen Sanni , Lehtimäki Terho , Kähönen Mika , Raitakari Olli ,   FinnGen Consortium, Mars Nina , Ruotsalainen Sanni , Kähönen Mika , Piltonen Terhi , Tuomi Tiinamaija , Daly Mark , Ripatti Samuli , Tukiainen Taru , Piltonen Terhi , Daly Mark , Tuomi Tiinamaija , Ripatti Samuli , Pirinen Matti , Tukiainen Taru 
Published: January 2023

Abstract
Background
Testosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes.

Methods
Leveraging genetic and health registry data from the UK Biobank and FinnGen (total N = 625,650), we constructed polygenic scores (PGS) for total testosterone, sex-hormone binding globulin (SHBG) and free testosterone, associating these with 36 endpoints across different disease categories in the FinnGen. These analyses were combined with Mendelian Randomization (MR) and cross-sex PGS analyses to address causality.

Results
We show testosterone and SHBG levels are intricately tied to metabolic health, but report lack of causality behind most associations, including type 2 diabetes (T2D). Across other disease domains, including 13 behavioral and neurological diseases, we similarly find little evidence for a substantial contribution from normal variation in testosterone levels. We nonetheless find genetically predicted testosterone affects many sex-specific traits, with a pronounced impact on female reproductive health, including causal contribution to PCOS-related traits like hirsutism and post-menopausal bleeding (PMB). We also illustrate how testosterone levels associate with antagonistic effects on stroke risk and reproductive endpoints between the sexes.

Conclusions
Overall, these findings provide insight into how genetically determined testosterone correlates with several health parameters in both sexes. Yet the lack of evidence for a causal contribution to most traits beyond sex-specific health underscores the complexity of the mechanisms linking testosterone levels to disease risk and sex differences.
Beeinträchtigung durch Kontextfaktoren: Fremd- und
Selbstbeurteilung von Rehabilitand:innen in der psychosomatischen
Rehabilitation
Authors: Passier Ines , Kobelt-Pönicke Axel 
Published: January 2023

Zusammenfassung
Ziel der Studie Ergänzend zu einem bestehenden
Fremdbeurteilungsinstrument zur ICF-basierten Erhebung der
Beeinträchtigung von Rehabilitand:innen durch umwelt- und personbezogene
Kontextfaktoren wurde ein Selbstbeurteilungsinstrument erstellt und bei
Rehabilitand:innen in einer psychosomatischen Rehabilitationsklinik eingesetzt.
Ziel war es, die Beurteilung der Beeinträchtigung durch Kontextfaktoren
durch die Fremdbeurteilung sowie durch die Rehabiltand:innen zu vergleichen und
erste Hinweise zur Anwendbarkeit des neu erarbeiteten
Selbstbeurteilungsinstruments zu erhalten. Bisher bestehende Fragebögen
zu Kontextfaktoren sind als Fremdbeurteilungsfragebögen konzipiert und
nicht explizit für den Einsatz in der psychosomatischen Rehabilitation
erprobt, weshalb die Erarbeitung eines Selbstbeurteilungsinstruments relevant
erscheint.
Methode An einer Stichprobe von N=103 Rehabilitand:innen wurden
sowohl das Fremdbeurteilungs- als auch das Selbstbeurteilungsinstrument
angewendet. Es erfolgte die vergleichende Auswertung der Einschätzungen
der Fremdbeurteilerin und der Rehabilitand:innen über Maße der
Beurteilerübereinstimmung (Cohenʼs Kappa, prozentuale
Übereinstimmung). Die Ergebnisse wurden mit Daten aus dem
Routine-Assessment der Rehabilitationseinrichtung in Beziehung gesetzt
(Eta-Koeffizient).
Ergebnisse Die Fremdbeurteilerin und die Rehabilitand:innen kamen in ihren
Einschätzungen bezüglich des Ausmaßes der
Beeinträchtigung durch einzelne Kontextfaktoren zu unterschiedlichen
Ergebnissen. Bei acht der 15 Kontextfaktoren zeigte sich lediglich ein
mäßiges Maß in der Beurteilerübereinstimmung
(Cohen’s Kappa). Die prozentuale nicht-Übereinstimmung zwischen
den Angaben in der Fremd- und Selbstbeurteilung lag bei der Mehrzahl der
Kontextfaktoren zwischen ca. 20% und bis zu ca. 40% der
Fälle. Ob über alle Kontextfaktoren hinweg (Gesamtmaß)
eine Beeinträchtigung vorlag oder nicht, wurde in knapp einem Drittel
der Fälle nicht-übereinstimmend beantwortet. Es zeigten sich
zumeist moderate Zusammenhänge zwischen den im
Selbstbeurteilungsinstrument besonders relevant eingestuften Kontextfaktoren und
Skalen psychometrischer Erhebungsverfahren (u. a. BDI-II). Dieses
Ergebnis gibt einen ersten Hinweis auf die konvergente Validität des
Selbstbeurteilungsinstruments.
Schlussfolgerung Einer ergänzenden Einschätzung der
Beeinträchtigung durch Kontextfaktoren über die
Selbstbeurteilung der Rehabilitand:innen neben der Fremdbeurteilung sollte noch
mehr Beachtung zukommen. Es besteht Forschungsbedarf im Hinblick auf die
Weiterentwicklung des vorgestellten Selbstbeurteilungsinstruments.
A Cross-Sectional Study on the Status of Contralateral Ear in Cases with Otitis Media Attending a Tertiary Care Center
Authors: V.K. Raghavan , S. Prabakaran , R.B. Namasivaya Navin , S. Rajasekaran 
Published: January 2023

Background
As the aeration and drainage entrances in both ears are the same, the factors that produce otitis media in one ear may also affect the other. Also, the unsolved debate is that long-standing otitis media turns into chronic otitis media (COM). Hence, this study was conducted with the objective of assessing the incidence of abnormal findings in the contralateral ear (CLE) and to find the association between the type of COM of diseased ear with the findings of CLE.

Materials and Methods
A hospital-based cross-sectional study was conducted among cases with unilateral COM who visited the outpatient department of otorhinolaryngology at Chettinad Hospital and Research Institute in Chennai between November 2021 and February 2022. The study comprised 200 COM cases in all. The medical history, otoscopic examination, pure-tone audiometry, and tympanometric findings of the patient were all documented. SPSS version 20 was used to conduct the analysis.

Results
About 80% of the individuals with COM in one ear exhibited some abnormalities in the CLE. The type of COM in the afflicted ear is not linked with the otoscopic findings, type of hearing loss, tympanometric findings, or overall abnormalities in the CLE. This study’s findings are comparable to those of several others.

Conclusion
Though there is no association between type of COM and the pathological findings in the CLE, considering the huge burden of pathological findings noted in the CLE, all cases of unilateral COM should be screened for aberrant findings in the CLE.
Impact of Different Histopathological Factors on Recurrence and Survival in Operated Carcinoma Esophagus
Authors: Singh Ashok Kumar , Singhal Basant Mohan , Yadav Santosh Kumar , Kewlani Vishal 
Published: January 2023

Background
Even with radical surgery, a significant percentage of patients of esophageal cancer experience recurrent disease.

Aims
The aim of the current study is to define the impact of different histopathological factors on the recurrence and survival in carcinoma esophagus following surgery.

Materials and Methods
A retrospective review of 182 patients of esophageal carcinoma, operated between January 2011 and December 2016, was done. In our study, 92 patients underwent upfront surgery and 90 took neo-adjuvant/perioperative treatment before planned surgery. To compare the proportion between two groups, chi-square test was used and to compare the median between the two groups, Mann—Whitney U test was used. Factors affecting the survival were analyzed using the Kaplan–Meier survival curve to compare the median survival time across groups log rank (Mantel–Cox) test was used.

Results
Out of 182 patients, 55 patients developed recurrences, in which 19 were loco-regional and 36 were systemic. Patients with lymph node-positive disease on final histopathology had more recurrence than lymph node-negative (39.74%, 31/78) versus (23%, 24/104), p = 0.01 (significant). Patients with features such as PNI-positive, poor differentiation, lymph node-positive, ENE, and higher stage disease had statistically significant, lower DFS and OS with p-value < 0.05. Patients with adenocarcinoma histology had more systemic recurrences and statistically significant lower DFS than SCC with p-value < 0.05.

Conclusions
Systemic recurrences are more common. PNI, ENE, grade, lymph node-positive disease, and higher pathologic stage had statistically significant negative impact on both DFS and OS. On multivariate analysis, whereas ENE had an impact on DFS alone.
An Overview of Neurotrauma Care in UCMS and GTB Hospital, New Delhi
Authors: Sarma Pragyan , Garg Manish 
Published: January 2023

AbstractUniversity College of Medical Sciences (UCMS) and the associated Guru Teg Bahadur Hospital (GTBH) is one of the largest tertiary care centers in the National capital of Delhi. It caters to a large volume of patients mainly from north east Delhi along with neighboring states of Uttar Pradesh and Haryana. Since the establishment of neurosurgery department in 1997, the department has contributed significantly toward neurotrauma care. With the upgradation of infrastructure in recent years, the department surely has a bright future in neurotrauma services benefiting a huge population. In this article, I have tried to describe the brief history of neurotrauma care, present status of manpower, and infrastructure to manage trauma patients, difficulties yet to overcome and roadmap for future.
Intimate strangers: theorizing bodily knowledge in shared housing
Authors: Törnqvist Maria 
Published: January 2023

AbstractWhat does it mean to know and relate to others in a domestic context characterized by physical, but not necessarily emotional, proximity? This article investigates the role of the body in converting strangers into intimate others within the setting of shared housing. Addressing phenomenological work on situated bodies as sites of perception in dialogue with sociological theories of embodiment and attunement, the article explores tacit everyday knowledge and its implications for the (subjective) construction of intimacy. Combining multisited observations and interviews, the study explores the intimate significance of privileged forms of knowing (of) others—lived on and by the body—and how these, at times, become habits of also caring for others. Although living under the same roof is not enough for there to be intimacy, the present study shows that shared housing evokes transgression of personal borders that pushes the limits between intimate and distant others in ways that expand our notion of what it means to know someone.
Engagement strategies in English and Arabic newspaper editorials
Authors: Alghazo Sharif , Al-Anbar Khulood , Jarrah Marwan , Rabab’ah Ghaleb , Al-Deaibes Mutasim 
Published: January 2023

AbstractThis study explores the use and functions of engagement strategies in English and Arabic newspaper editorials. To this end, the study analyses 80 editorials collected from two popular newspapers (40 from each): The Guardian which publishes in English and appears in the UK and Addustour which publishes in Arabic and appears in Jordan. Following Paltridge’s (2020) taxonomy, the study utilises a mixed-method approach to assess whether differences in the use of engagement strategies between the two corpora are statistically significant and to identify the functions of the strategies used in the two sets of data. The findings show that there are statistically significant differences between the two languages in the use of some engagement strategies. In particular, Arabic editorials included more reader pronouns and less personal asides than did English ones. In addition, although questioning as an engagement strategy was absent in the Arabic corpus, it was used in the English one to transmit information and circulate knowledge. The findings enrich our understanding of how the editorial genre is constructed, and how editorialists engage with their readers in the two languages.
Design and experimental characterization of a bypass magnetorheological damper featuring variable stiffness and damping
Authors: Abdalaziz Moustafa , Vatandoost Hossein , Sedaghati Ramin , Rakheja Subhash 
Published: January 2023

Abstract
Magnetorheological (MR) fluid dampers (MRFDs) with variable stiffness and variable damping capability (VSVD-MRFDs) have demonstrated excellent vibration mitigation performance. However, there are limited studies on the development of bypass VSVD-MRFDs which offer both higher dynamic range and output force, apart from simple maintenance and straightforward assembly. In this study, a novel large-capacity VSVD-MRFD with an annular-radial bypass MR valve, as opposed to the typical practice of implementing the valve within the traveling piston in the hydraulic cylinder of the MRFD, is proposed. The main contribution of the present work includes: (a) providing the conceptional design and experimental dynamic characterization of the proposed VSVD-MRFD; (b) investigating the feasibility of the proposed damper for realizing the VSVD characteristics under wide ranges of loading conditions. A test rig was, thus, designed to perform experimental characterization of the proposed VSVD-MRFD under wide ranges of mechanical loading and magnetic field conditions. A qualitative analysis including force-displacement, and force-velocity characteristics, together with a quantitative analysis including dynamic range, equivalent viscous and stiffness coefficients, were conducted as a function of loading frequency, displacement amplitude, and applied current. Results showed a maximum dynamic range and maximum output force of 4.5 and 7.8 kN, respectively. Also, the maximum relative increase in the equivalent viscous and stiffness coefficients were obtained, respectively, as 425% and 488%, when the applied current is increased from zero to 2 A. The results confirm the potential of the proposed VSVD-MRFD for applications in off-road suspension systems. The externally designed bypass MR valve permits a straightforward design modification for realizing wide scalability of damping force in different applications (e.g., off-road vehicle suspension systems).
Model of radiant capillary heating and cooling system
Authors: Bolotin Kirill , Jakovics Andris , Telicko Jevgenijs 
Published: January 2023

Abstract
Paper is devoted to the development and verification of a tool for modeling and designing radiant-panel heating and cooling systems. Source of radiation is capillary mats, which consist of tubes through which water flows with a temperature of 18°C to 32°C, depending on the operating mode. The tool is an analytical model that takes into account the radiation from capillary mats located on the ceiling and walls, the mutual radiation of all surfaces in the room, including doors and windows, simplified convection, as well as third-party sources of thermal energy, such as the sun, electronics and people. The model was compared with a similar numerical model created in Comsol Multiphysics, and also verified by experimental data.
Ordinary gypsum plasterboard and Knauf Torro gypsum plasterboard bullet-proofing
Authors: Barone E , Vetra R , Gaujena B , Vilnitis M 
Published: January 2023

Abstract
Bullet-proof walls are recently attractive also outside of specialized areas with the most threat of attack. Nevertheless, an average wall cannot protect us from an intentional or stray bullet. Therefore, five stands were made of gypsum wall panels, ordinary plasterboard, and Knauf bullet-proof plasterboard, fired with two different calibers of weapons. The results were documented through photography. The test results show the ballistic resistance of enhanced materials, not ordinary plasterboard. The obtained results are compared with the technical information. The aim was to test whether plasterboard, the most used material in construction, is comparable to bullet-proof structures. These results will be used to complement the standard LVS 1061 “Gypsum boards and board systems. Design and use rules”, as well as for individual use in protection against external bullet threats or to prevent ricochets.
Morphology and mechanical properties of PAN nanofiber mat
Authors: Sanchaniya J V , Kanukuntla S 
Published: January 2023

Abstract
Nanofibers have acquired greater interest due to their vast variety of possible uses. Nanofibers offer several options to change things physically and chemically during or after the manufacturing process to give them new properties. To exploit the full potential of nanofibers, it is necessary to comprehend the link between the mechanical characteristics, particularly tensile strength, of a nanofiber mat and its morphology. Electrospinning is a rapidly developing polymer processing technology because it provides a simple and effective method for manufacturing nano continuous fibres. This method permits the deposition of nanofibers on revolving collectors. Rotating collectors, such as the drum and electrodes with a gap between them, may readily form oriented fibres. Polyacrylonitrile is a common precursor material for carbon nanofibers (PAN). This research investigates the impact of collector drum’s rotation speed on the morphology of the nanofiber mat and discusses the mechanical properties of Polyacrylonitrile (PAN) electro spun nanofiber mats with precisely aligned nanofibers. PAN nanofiber mats have more tensile strength (~37 %) than PA6 nanofiber mats and have (50 %) less elongation than PA6 nanofiber mats, according to a comparison with previous studies.
Influence of limestone filler on technological parameters of mixtures for 3D concrete printing
Authors: Joon Hillar , Hass Lauri , Peetrimägi Lauri 
Published: January 2023

Abstract
This paper focuses on the use of fine-ground limestone filler (LP) from Rakke Limestone production (R0) as SCM in 3D Concrete Printing (3DCP) mixtures to partially replace OPC. Important technical aspects of the mixture, such as flowability, extrudability and buildability, are explored and investigated. To properly deploy 3DCP, two conflicting material qualities must be balanced. On one hand, the mix must be pumpable enough to be delivered by hose from the mixer to the nozzle, and on the other, after extrusion, the mix must retain its shape without any supporting formwork while bearing the load from succeeding filaments. In cooperation with MIRA Ehitusmaterjalid OÜ experimental mixtures with various OPC replacements were produced, which were printed on a gantry printer at Tallinn University of Applied Sciences. A comparison was made using industrial mixtures from Weber Saint-Gobain - Beamix 145-2 and ESL. LP has been found to enhance mix printability despite higher water requirement. This can be attributed to additional finely dispersed flocculation centres provided by LP additive. With the same, LP reduces buildability of the mixtures caused by slower yield stress growth and retarded stiffening.