bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remotely prescribed and monitored home-based gait-and-balance therapeutic exergaming using augmented reality (AR) glasses: protocol for a clinical feasibility study in people with Parkinson’s disease
Authors: Hardeman Lotte , Geerse Daphne , Hoogendoorn Eva , Nonnekes Jorik , Roerdink Melvyn 
Published: June 2023

Abstract
BACKGROUND
Clinical guidelines for people with Parkinson's disease (pwPD) stress that, complementary to pharmacological treatment, exercise and physical therapy should be given a central role to disease management. Adhering to regular exercise of the right type, and with high repetition, remains a challenge for pwPD. Exergaming has the potential to increase adherence through play and personalised interventions, both in clinic and at home. Reality DTx® is an augmented-reality (AR) home-based gamified gait-and-balance exergaming intervention specifically designed for pwPD as an extension of supervised physical therapy. The primary objective of this study is to evaluate the feasibility and potential efficacy of Reality DTx®.
METHODS
Twenty-four individuals with PD (Hoehn & Yahr stage 2–4) with self-reported gait-and/or-balance impairments will participate in this study. The study comprises a 6-week waitlist-controlled AR home-based therapeutic gait-and-balance exergaming intervention. Reality DTx® will initially be prescribed remotely for minimally five days a week for 30 minutes per day. We will remotely set and adjust the frequency, difficulty, type of games and/or duration on a weekly basis, based on objective and subjective data from the AR glasses and participant, respectively. In addition to the home-based gait-and-balance exergaming intervention, the study comprises three laboratory visits: before the 6-week waitlist period (t0; baseline), before the 6-week intervention period (t1; pre-intervention) and after the 6-week intervention period (t2; post-intervention). The primary study parameters are feasibility (in terms of safety, adherence and user experience) and potential efficacy for improving gait and balance (using standard clinical gait-and-balance tests and a targeted walking-related fall-risk assessment). Recruitment started in December 2022 and the final post-intervention assessment will according to planning be in July 2023.
CONCLUSIONS
This clinical feasibility trial is the first remotely prescribed and monitored home-based AR gait-and-balance exergaming intervention for pwPD. The results in terms of clinical feasibility (i.e., safety, adherence and user experience) and potential efficacy (gait, balance and fall-risk outcomes) form the basis for future randomised controlled studies on the effectiveness of home-based AR gait-and-balance exergaming interventions for pwPD.
Trial registration
ClinicalTrials.gov, NCT05605249, Registered 4 November 2022, https://clinicaltrials.gov/ct2/show/NCT05605249
Soil nutrient limitation and natural enemies promote the establishment of alien species in native community
Authors: Xu Yu-Han , Guo Yu-Jian , Bai Yan-Feng , Liu Yuan-Yuan , Yan Zhao-Gui , Wang Yong-Jian 
Published: June 2023

Abstract
Background and Aims
The invasion of alien plant species poses a threat to native community’s composition and diversity. However, the invasiveness of alien plants and invasibility of native communities should be depended on the interactions between biotic and abiotic factors, such as natural enemies and soil nutrient availability.
Methods
We simulated the invasion of nine invasive plants into native plant communities with two levels of soil nutrient availability and natural enemies suppression. We explored how the biotic and abiotic factors affect the response of alien target species and the resistance of native communities to invasion.
Results
Enemy release (i.e., presence of enemy) increased biomass proportion of alien plants and decreased that of native community under without nutrient addition. Furthermore, the negative effect of enemy suppression on the evenness of native community and the root-to-shoot ratio of alien target species was greatest under nutrient addition.
Conclusion
Soil nutrient deficiency and natural enemies might promote the invasive success of alien species in native community, whereas nutrient addition and enemy suppression can better enhance the resistance of native plant communities to invasion.
Assessing Opportunities of SYCL and Intel oneAPI for Biological Sequence Alignment
Authors: Costanzo Manuel , Rucci Enzo , García-Sanchez Carlos , Naiouf Marcelo , Prieto-Matías Manuel 
Published: June 2023

Abstract
Bioinformatics and Computational Biology are two fields that have been exploiting GPUs for more than two decades, with being CUDA the most used programming language for them. However, as CUDA is an NVIDIA proprietary language, it implies a strong portability restriction to a wide range of heterogeneous architectures, like AMD or Intel GPUs. To face this issue, the Khronos Group has recently proposed the SYCL standard, which is an open, royalty-free, cross-platform abstraction layer, that enables the programming of a heterogeneous system to be written using standard, single-source C++ code. Over the past few years, several implementations of this SYCL standard have emerged, being oneAPI the one from Intel. This paper presents the migration process of the SW# suite, a biological sequence alignment tool developed in CUDA, to SYCL using Intel’s oneAPI ecosystem. The experimental results show that SW# was completely migrated with a small programmer intervention in terms of hand-coding. Moreover, it was possible to port the migrated code between different architectures (considering multiple vendor GPUs and also CPUs), with no noticeable performance degradation on 5 different NVIDIA GPUs. As a consequence, SYCL and Intel oneAPI can offer attractive opportunities for the Bioinformatics community, especially considering the vast existence of CUDA-based legacy codes.
Emergence of Two High-pressure Superconducting Phases in Pressurized Optical Semiconductor GaP
Authors: Qian Nixian , Zhang Ranran , Chen Chunhua , Chen Xuliang , Yang Zhaorong , An Chao , Zhou Ying , Zhang Min , Yuan Yifang , Zhou Yonghui 
Published: June 2023

Abstract
Pressure engineering in semiconductors leads to a variety of novel physical phenomena and has recently obtained considerable attention. Here we report on pressure-induced superconductivity in III-V gallium phosphide (GaP), a commercially important semiconductor that exhibits excellent optical performances. We show that the emergence of superconductivity is accompanied by concurrence of piezochromic transition and metallization, and can be correlated to a structural transition from cubic to orthorhombic phase. In line with structural origin of the superconductivity, the critical temperature Tc decreases monotonically with increasing pressure up to ~ 50 GPa. Moreover, the superconductivity could be preserved toward ambient pressure because of the irreversibility of the structural transition. Nevertheless, the superconducting transition displays evident broadening associated with the presence of amorphization in the depressurized sample. The synchronous evolution of the structural and electronic properties not only documents a vivid structure–property relationship, but also sheds light on exploring novel functionalities by means of pressure treatment.
Unified plastic limit analysis of the cap periphery formation in orbital drilling of titanium alloy
Authors: Zhou Lan , Zhong Yun , An Guosheng , Dong Hongfeng , Zheng Min , Zhu Zongxiao 
Published: June 2023

Abstract

The cap geometry and formation mechanism play a key role in influencing the hole-making quality on the bore exit side and must be the focus of research in orbital drilling of aeronautical metal materials. For a “bowl shape” cap geomery formed in orbital drilling process, the corresponding undeformed cap periphery geometry, generated by the cap periphery cutting edges, is simulated and given the parametric description. Especially, the cap periphery is simplified as a simply supported annular plate under uniform load with arbitrary loading radius based on the charateristics of the cap peripheray shape and mechanical analysis of processing. Then its unified plastic limit analysis is developed. The ultimate load, stress field, and plastic deformation at the periphery of the cap are derived from the unified strength theory. Furthermore, the numerical solutions are obtained in terms of the Tresca yield, Huber–von Mises, and twin-shear yield criteria. The conclusions enabled an in-depth understanding of the cap periphery formation mechanism in the orbital drilling of holes from the unified plastic limit analysis perspective.
Agar-based optical sensors for electric current measurements
Authors: Fujiwara Eric , Rosa Lidia , Oku Hiromasa , Cordeiro Cristiano 
Published: June 2023

Abstract
Biodegradable optical waveguides are breakthrough technologies to light delivery and sensing in biomedical and environmental applications. Agar emerges as an edible, soft, low-cost, and renewable alternative to traditional biopolymers, presenting remarkable optical and mechanical characteristics. Previous works introduced agar-made optical fibers for chemical measurements based on their inherent response to humidity and surrounding concentration. Therefore, we propose, for the first time, an all-optical, biodegradable electric current sensor. As flowing charges heat the agar matrix and modulate its refractive index, we connect the optical device to a DC voltage source using pin headers and excite the agar sample with coherent light to project spatiotemporally deviating speckle fields. Experiments proceeded with spheres and no-core fibers comprising 2 wt% agar/water. Once the increasing current stimulates the speckles’ motion, we acquire such images with a camera and evaluate their correlation coefficients, yielding exponential decay-like functions whose time constants provide the input amperage. Furthermore, the light granules follow the polarization of the applied voltage drop, providing visual information about the current direction. The results indicate a maximum resolution of ~0.5 µA for electrical stimuli ≤ 100 µA, which fulfills the requirements for bioelectrical signal assessment.
Twitter - a new citizen science solution for urban flood database #urban floods #flood database
Authors: Ponukumati Padmini , Regonda Satish Kumar 
Published: June 2023

Abstract
High spatial heterogeneous behavior of urban floods offers challenges in its monitoring, modeling and assessment, and lack of flood database further increases complexity. This study proposes a twitter-based framework to develop a flood database. Three flood events differing in rainfall characteristics are selected, and event-specific flood inventories are developed using the proposed framework. The inventory was validated with newspaper-based information. Analysis of tweets imply a broad agreement among both twitter- and newspaper- based flooding instances, however, highlight the need to include identifiable location information in tweets. Further, the results suggest floating and using of hashtags, and importantly active participation of individuals and various agencies aids in the development of reliable and accurate flood inventory of decent size. Integration of artificial intelligence and machine learning techniques allows to develop cost-effective flood inventories of finer space-time resolutions with minimized manual efforts for many cities around the world; the developed flood inventories make many urban areas data rich; thus it decreases complexity of urban flood relevant challenges at least by one important dimension, thereby plays a key role in modeling and mitigation efforts.
Association of Nidus Size and Rupture in Brain Arteriovenous Malformations: Insight from Angioarchitecture and Hemodynamics
Authors: Li Ruinan , Chen Pingting , Han Heze , Li Zhipeng , Chen Xiaolin , Chen Yu , Zhao Yuanli 
Published: June 2023

Abstract
Objective: This study aims to investigate the correlation between AVM size and rupture by examining natural history, angioarchitecture characteristics, and quantitative hemodynamics.
Methods: A retrospective review of 90 consecutive AVMs from the MATCH registry was conducted. Patients were categorized into small nidus (<3cm) and large nidus (≥3cm) groups based on the Spetzler-Martin grading system. Natural history analysis used prospective cohort survival data, while imaging analysis examined angioarchitecture characteristics and quantitative hemodynamic parameters measured with QDSA.
Results: The small-nidus group had a significantly higher annualized rupture risk (2.3% vs. 1.0%; p = 0.011). Cross-sectional imaging revealed independent hemorrhagic risk factors, including small nidus (OR, 4.801; 95%CI, 1.280–18.008; p = 0.020) and draining vein stenosis (OR, 6.773; 95%CI, 1.179–38.911; p = 0.032). Hemodynamic analysis identified higher stasis index in the feeding artery (OR, 2.442; 95%CI, 1.074–5.550; p = 0.033), higher stasis index in the draining vein (OR, 11.812; 95%CI, 1.907–73.170; p = 0.008), and lower outflow gradient in the draining vein (OR, 1.658; 95%CI, 1.068–2.574; p = 0.024) as independent predictors of AVM rupture. The small nidus group also showed a higher likelihood of being associated with hemorrhagic risk factors.
Conclusion: Small AVM nidus has a higher risk of rupture based on natural history, angioarchitecture, and hemodynamics
Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT04572568
Fast, selective and sensitive fluorescence detection of levofloxacin, Fe3+ and Cu2+ ions in 100% aqueous solution via their reciprocal recognition
Authors: Nazarian Ramo , Darabi Hossein Reza , Aghapoor Kioumars , Sayahi Hani , Mohsenzadeh Farshid , Atasbili Leila 
Published: June 2023

Abstract
The fluorescence detection of ions and pharmaceutical effluents by using organic chemosensors is a valuable surrogate to the currently existing expensive analytical methods. In this regard, the design of multi-functional chemosensors to recognize desirable guests is of utmost importance. In this study, we first show that levofloxacin (LVO) is able to use as a fluorescent chemosensor for the detection of biologically important Cu2+ (turn-off) and Fe3+ (turn-on) ions via independent signal outputs in 100% aqueous buffer solutions. Next, using the reciprocal recognition of LVO and Fe3+ provides a unique emission pattern for the detection of LVO. This approach exhibited a high specificity to LVO among various pharmaceutical samples, namely acetaminophen (AC), azithromycin (AZ), gemifloxacin (GEM) and ciprofloxacin (CIP) and also showed great anti-interference property in urine. The attractive features of this sensing system are availability, easy-to-use, high sensitivity (limit of detection = 18 nM for Cu2+, 22 nM for Fe3+ and 0.12 nM for LVO), rapid response (5 s) with an excellent selectivity.
Prognostic Value of Isolated High Serum Cystatin C Levels Without Glomerular Filtration Rate Reduction
Authors: CANCHO BARBARA , LOPEZ ALVARO ALVAREZ , VALLADARES JULIAN , SABILLON JORGE ALBERTO RODRIGUEZ , GOMEZ JUAN LOPEZ , ROBLES NICOLAS ROBERTO 
Published: June 2023

Abstract

OBJECTIVES: Cystatin C is increasingly used as a marker of renal function as a complement or alternative to serum creatinine and GFR calculated from it. However, cystatin C is also a marker of inflammation. We have assessed its efficacy as a predictor of mortality in a group of patients with increased cystatin C and GFR > 60 ml/min.
DESIGN AND METHODS: We included 608 patients seen at our hospital, 65.9% of whom were male and 34.6% had diabetes mellitus. The mean age was 58.5±14.5 years and a mean GFR of 64.1±33.5 ml/min. Patients were divided into 3 groups: CONTROL (normal cystatin C and GFR > 60 ml/min, age 53.3±12.8 years, GFR 96.6±22.4 ml/min, n=193), INCREASED CYSTATIN (increased cystatin C and GFR >60 ml/min, age 58.9±13, 1 years, GFR 72.2± 10.4 ml/min, n = 40 ) and CKD (chronic kidney disease, increased cystatin C and GFR <60 ml/min, age 61.4±14.8 years, GFR 36.0±12.7 ml/min, n = 160). The relationship with overall mortality was analyzed using the survival curve by Kaplan-Meier method.
RESULTS. Mean cystatin C was 0.75±0.13 mg/l, versus 1.79±0.54 in the CKD group and 1.14±0.14 mg/l, p<0.001 ANOVA). In the CONTROL group survival was 93.9% at five years, compared to 78.8% in the ERC group and 82.3% in the INCREASED CYSTATIN group (p < 0.001 Log Rank). Five-year survival before renal replacement therapy was also different for the ERC group (73%, p < 0.001 Log Rank) but not between the other two groups (CONTROL 99.0%, INCREASED CYSTATIN 94.3% p = 0.08 Log Rank).
CONCLUSIONS. The presence of increased plasmatic levels of cystatin C in patients with GFR > 60 ml/min was a predictor of increased mortality but not of progression to end-stage renal failure. These results confirm the interest of routinely measuring cystatin C in our patients.
The TNFR-RIPK1/RIPK3 signalling pathway mediates the effect of lanthanum on necroptosis of nerve cells
Authors: Jin Bihui , Ding Zhe , Sun Yujiao , Gao Shujuan , Sui Xinyu , Ding Mengping Zhe , Qu Xinyi , Zheng Linlin 
Published: June 2023

Abstract

By observing the changes in hippocampal nerve cell damage in offspring rats exposed to different doses of lanthanum chloride (LaCl3), the role of TNFR-RIPK1/RIPK3 necroptosis pathway in La-mediated neurotoxicity was explored. At 49 days after the birth of the LaCl3-exposed offspring rats, neurobehavioural tests were performed to assess the spatial learning and memory; the ultrastructure of hippocampal tissues of the offspring rats was observed by electron microscopy; the number of Nissl bodies in hippocampal tissue was evaluated by Nissl staining; and the protein contents of TNFR-RIPK1/RIPK3 signalling pathway in hippocampal tissue were measured by Western blotting. The learning and memory ability of the offspring decreased after LaCl3 exposure. Nissl staining showed that in the lanthanum-exposed rats, Nissl body number in the hippocampus was significantly decreased, and the cell arrangement was disordered. The ultramicroscopic structure of hippocampal neurons in lanthanum-exposed rats showed that the mitochondrial volume was increased; ridges were shorter, decreased in number, and marginally shifted; and the matrix electron density was also decreased. Western blotting proved that the contents of TNFR1, P-RIPK1, P-RIPK3 and P-MLKL in hippocampal neurons increased significantly as the LaCl3 dose increased. Lanthanum exposure retarded the growth and development of rat offspring ,impaired spatial learning and memory, and induced mitochondrial damage in hippocampal neurons, resulting in cellular necroptosis .These changes may be related to abnormal expression of TNFR-RIPK1/RIPK3 signaling pathway-related molecules.
Reproductive behavior of three mobulid species (Mobula mobular, Mobula thurstoni and Mobula munkiana) in the Southern Gulf of California, Mexico
Authors: Palacios Marta D , Trejo-Ramírez Abel , Velázquez-Hernández Sidharta , Huesca-Mayorga Scarlett A. K. , Stewart Joshua D. , Cronin Melissa R. , Lezama-Ochoa Nerea , Zilliacus Kelly M. , González‑Armas Rogelio , Galván‑Magaña Felipe , Croll Donald A. 
Published: June 2023

Abstract
We examined the reproductive behavior (courtship and mating) and its seasonality in three mobula species, spinetail, bentfin, and munk’s devil rays (Mobula mobular, M. thurstoni, and M. munkiana) in the southwestern Gulf of California, Mexico, using boat surveys (with drones and in-water observation) (n = 69 survey days), spotter planes (n = 428 flights) and citizen science observations (n = 31). We examined whether (1) reproductive grounds existed within the area for any of these species, (2) reproductive behavior followed seasonal patterns and (3) if this behavior was similar among species. We observed reproductive behavior in 221 sessions in 2017 and 2021–2022, for M. mobular (n = 10), M. thurstoni (n = 3), and M. munkiana (n = 208) dispersed along 312 km of the eastern Baja California Peninsula between 4 m to 6.3 km away from the coast. Most events (n = 209) occurred in the La Ventana and Ensenada de Muertos area. Courtship was observed for M. mobular and M. thurstoni and mating for M. munkiana, with reproductive behavior following a seasonal pattern occurring from March to August, with a peak during May. M. munkiana displayed a previously undescribed behavior, the “courtship vortex”, where 122 individuals were observed circling in a clockwise direction for five hours with mating groups joining and leaving the main vortex formation. This study highlights the area of La Ventana and Ensenada de Muertos as a critical habitat for reproductive behavior of three endangered and vulnerable mobulid species.
Assessment of economic inequality during three decades in Aceh Province of Indonesia
Authors: Abdullah Razali , Fulazzaky Mohamad Ali 
Published: June 2023

Abstract
Political reform and the terrible aftermath of the 2004 tsunami in Sumatra have caused a state of income inequality among the Aceh people. The aim of this study was to determine the income inequality of Aceh people using Theil index while the analysis of panel data was used to predict the relationship between income inequality and economic growth for groups of people in three regions of Aceh Province. The results showed the income inequality of Aceh people remained low over two decades and increased to approximately eight times after the fall of New Order regime. Impact of post-2004 tsunami disaster recovery on the tsunami affected areas of Aceh Province has helped to reduce economic inequality. Administrative decentralisation of Aceh Province after political reform as part of democratisation in Indonesia has made a contribution to the realisation of basic human rights, leading to improve the living standards and accelerate economic growth.
Renoprotective effects of therapeutic hypothermia in neonates with perinatal asphyxia
Authors: Aydın Banu , Okumuş Nurullah , Özkan Mehmet Burak , Zenciroğlu Ayşegül , Dilli Dilek , Beken Serdar 
Published: June 2023

Abstract
Background To compare renal blood flow and renal function tests in infants with perinatal asphyxia, and the effects of therapeutic hypothermia(TH) during the first seven days of life.
Methods Fifty-nine patients with hypoxic ischemic encephalopathy(HIE) were prospectively evaluated. Patients with stage 2-3HIE who required TH were classified as Group1(n=36), patients with Stage 1 HIE who did not need TH were classified as Group2(n=23), and healthy infants were classified as Group3(n=60). Renal function tests were evaluated on the 6th hour, 3rd and 7th days of life in Group1 and Group2, and on the 6th hour and 3rd day of life in Group3. KDIGO Classification was used to diagnose AKI in all patients. Renal artery(RA) Doppler ultrasonography(dUS) was performed in all infants on the 1st, 3rd and 7th days of life.
Results Serum cystatinC levels were gradually decreased and glomerular filtration rate(GFR) was gradually increased during TH on Group1. Systolic and end-diastolic blood flow in RA tended to increase and RA resistive index (RI) tended to decrease with time in Group1. While end-diastolic blood flow rates in RA on the 3rd day was similar in patients with stage3 HIE and stage 1 HIE, it was lower in patients with stage 1,2,3 HIE than healthy newborns. On the 7th day, all the three groups had similar values. Stage 3 AKI was not observed in any of the cases.
Conclusion Therapeutic hypothermia seems to help to restore the renal blood flow and renal functions during the neonatal adaptive period along with its neuroprotective properties.