bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 5909: Characterization of the lung cancer microbiome using whole genome sequencing
Authors: McElderry John , Zhang Tongwu , Shi Jianxin , Landi Maria Teresa 
Published: April 2023

Abstract
Microbiome studies have been rapidly increasing over the last decade, providing valuable insights into the commensal bacterial contribution to human physiology and disease, including human cancer. Many studies have demonstrated the important roles of the microbiome in cancer progression, anti-tumor immunity, resistance to therapies, metastasis formation, and in some rare cases even cancer development through the production of genotoxins. However, relatively few studies have analyzed the lung cancer microbiome, and both its composition and role in cancer progression are largely unknown. To characterize the microbiome of tumor and matched normal lung tissues, we performed whole-genome sequencing (WGS) in 872 never smokers using the Kraken pipeline. At the phylum level, WGS analyses of tumor and normal samples showed predominantly Proteobacteria and Actinobacteria (58% and 32%, respectively). Notably, we found overall similar microbiome composition in tumor and normal lung tissue samples. At the genus level, Cutibacterium, Klebsiella, Pseudomonas, Sphingomonas, Staphylococcus, and Acinetobacter genera were among the most abundant bacteria in tumor and normal tissues, alike, and the genera Prevotella, Corynebacterium, and Streptococcus were more abundant in tumor samples compared to normal lung tissue. Comparison of alpha diversity at the genus level between tumors and normal samples showed no substantial difference. We are currently investigating whether the microbiome composition varies by lung tumor anatomical location, sex, histology, study subjects’ geographical location, and immune microenvironment. We will also investigate whether the tumor microbiome composition varies in relation to important genomic features, like cancer driver genes and mutational signatures. Finally, we have 16s rRNA seq data from 771 tumor and normal lung tissues from never smokers and we will compare bacterial microbiome composition and diversity based on WGS and 16s rRNA seq for the same samples. This study, based on the largest analysis of lung microbiome to date, is poised to provide important insights into the role of commensal microbiota in shaping lung tumor development and progression.
Citation Format: John McElderry, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi. Characterization of the lung cancer microbiome using whole genome sequencing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5909.
Abstract SY12-04: Lowering the TCR signaling threshold with a DGKa/z dual inhibitor potentiates anti-tumor immunity
Authors: Dougan Stephanie K. 
Published: April 2023

Abstract
Checkpoint blockade immunotherapies expand neoantigen- or virus-specific T cells, and poor responsiveness to immunotherapy is associated with lower mutational burden in tumors of non-viral origin. Although mouse models demonstrate that lower affinity T cells recognizing self-antigens can contribute to tumor control if sufficiently activated, therapeutic options for enhancing T cell priming are limited. Diacylglycerol kinases (DGKs) suppress DAG signaling by converting DAG to phosphatidic acid, thereby attenuating pathways downstream of TCR signaling. Using a novel dual DGKa/z inhibitor (DGKi), tumor-specific CD8 T cells with different affinities (TRP1high and TRP1low), and a series of altered peptide ligands, we demonstrate that inhibition of DGKa/z can lower the signaling threshold for T cell priming. TRP1high and TRP1low CD8 T cells produced more IL-2 and IFNγ in the presence of cognate antigen and DGKi. Effector TRP1high- and TRP1low-mediated cytolysis of tumor cells with low antigen load was MHC-restricted, mediated by IFNg and augmented by DGKi. Adoptive T cell transfer into mice bearing pancreatic or melanoma tumors synergized with single-agent DGKi or DGKi and αPD1, with increased expansion of low affinity T cells and increased cytokine production observed in tumor infiltrates of treated mice. Collectively, our findings highlight DGKa/z as therapeutic targets for augmenting tumor-specific CD8 T cell function.
Citation Format: Stephanie K. Dougan. Lowering the TCR signaling threshold with a DGKa/z dual inhibitor potentiates anti-tumor immunity. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr SY12-04.
Redescription of Pumiliopes scombri Izawa, 2021 (Copepoda, Cyclopoida, Bomolochidae) recovered from Scomber japonicus Houttuyn, 1782 (Actinopterygii) in Japan, with description of the male of the species
Authors: Izawa Kunihiko 
Published: April 2023

Abstract
Pumiliopes scombri Izawa, 2021 is redescribed based on specimens of both sexes recovered from the bucco-branchial cavity of the chub mackerel, Scomber japonicus Houttuyn, 1782 (Scombriformes, Scombridae), in Japan. The male of the species is described for the first time. The description of the male is also the first time for the genus. This genus is unique in having an antenna that is sexually dimorphic.
The Export of Books from the Dutch Republic to the Southern Netherlands
Authors: Thissen Peter 
Published: April 2023

Abstract
In a previous article the export of books printed in the Republic to the Southern Netherlands (16th–18th centuries) was estimated based on one library only. This research is being done again in the current article, now based on the book lists of 120 monastery libraries suppressed in 1783. This gives the opportunity not only to see if the previous estimates can be confirmed but also to investigate which type of convent (sex, library size) was more likely to buy books printed in the Republic.
Standards for Lettering
Authors: Lommen Mathieu 
Published: April 2023

Abstract
As part of an increasing urge for standardisation, examples for executing utilitarian lettering appeared in the twentieth century. In the design world, standardisation was not uncontroversial: the customary opposition between commercial reality and the cultural elite. This article, partly based on archival research, examines the history and creation of NEN 3225, which is the best-known Dutch standard letter. The lettering project started in 1944, during the German occupation, and it was not until 1962 that this standard appeared in book form. The celebrated type designer J. van Krimpen was a member of the responsible committee. He had strong design ideals. Unlike the lowbrow German standard letter DIN 1451, NEN 3225 proved not to be easy to execute for less experienced craftspeople.
Sua fata
Authors: Leerssen Joep 
Published: April 2023

Abstract
The early decades of the 19th century witnessed, all over Europe, a surge of Romantic historicism which affected, not only the production of fresh texts, but also the (re-)discovery and edition of ancient ones. While this phenomenon spawned the paradigm of the “national literatures” across Europe, neither its transnational spread nor its receptive/productive dualism can be properly charted by the “national” literary historiography which emerged in its wake. A book-historical approach is here offered instead.
Šeḫ Muḥammad Aršad al-Banjarī and the Application of Critical Theological Interpretations to Local Traditions in Banjar Region, Indonesia
Authors: Wardani  , Ibrahim Mazlan , Nadhiroh Wardatun 
Published: April 2023

Abstract
It is undeniable that Religion and tradition have been a highly discussed discourse from the past up to the present day. Interpretation of the Qurʾan is one essential aspect of religion that serves not only as a way of understanding its doctrines, but also as a media controlling local beliefs and practices. This article is aimed at analyzing Šeḫ Muḥammad Aršad’s interpretation of theology-verses quoted to support his theological ideas in his Tuḥfat al-Rāġibīn. Employing trans-disciplinary approaches consisting of Quran interpretation as distinction between interpretation (tafsīr) and application (taṭbīq), and post-colonial criticism of the high-low tradition category, it concludes that first, Šeḫ Aršad’s treatment of the Qurʾanic verses does not prove that he freely interpreted the Qurʾan the way he wanted, but he applied the given verse-interpretation, and this method constitutes a partial interpretation of theology-verses; second, that such use interpretation method, in his perceived innovations, coupled by his position in the Sultanate of Banjar, was projected to purify, the perspective of Ahl al-Sunna wa-l-Jamāʾa, from some local traditions, such as manyanggar banua and mambuang pasilih.
Pendengaran Membangun Akal Menurut Al-Quran: Panduan Kepada Gen Z Mind Building with Listening according to Al-Quran: A Guide for Gen Z
Authors: Nor Hafizah Mohd , Abd Razzak Monika@Munirah , Norasid Muhamad Alihanafiah 
Published: April 2023

Abstract
Gen Z is a group of people who are more inclined towards virtual communication. This inclination has been influenced by their dependency on the smart phone and social media that results in internet addiction. Without realising it, their interpersonal communication skills are affected which among others is active listening (AL). Gen Z was found to have difficulty practicing an effective listening process when interacting with others face-to-face as the focus was more directed towards the device. To overcome this issue, references from the al-Quran on AL has been analysed with a focus on the element of mind building with listening (MBL). This research uses the qualitative method and data collected are from the books of exegesis that discusses this component of MBL and literature from previous research. A total of six verses of the Quran themed ‘سَمِع’ were selected and analyzed. Five tafsir books are referred to as primary sources to discuss the interpretation of sentences by focusing on the components in PMA. The results showed that suggested five components that could improve AL among Gen Z are to i) apply the value of Iman ii) receive and give attention iii) think, understand and evaluate iv) enquire and to v) respond and take action. It is therefore hoped that gen Z will benefit from this MBL and to practice it in communication that will consequently improve their interpersonal relationships with those important to them.
Manuskrip Al-Quran Madura: Analisis Terhadap Kodikologi Manuskrip al-Quran MSS 4322 Koleksi Perpustakaan Negara Malaysia Manuscripts of Al-Quran in Madura: An Analysis of the Codicology of Manuscripts al-Quran MSS 4322 from National Library of Malaysia Collection
Authors: Omar Siti Azwanie Binti Che , Ariffin Sedek Bin 
Published: April 2023

Abstract
Copying Mashaf Al-Quran with handwriting became a tradition of the Malay community once upon a time as a vehicle for the spread of Islam in the archipelago. As a result, the scientific heritage of the Islamic community in the form of manuscripts or printed materials produced with high quality. Therefore, this article’s purpose is to elucidate the history of the al-Quran manuscript writing in Indonesia, and also explain in detail about the history of al-Quran manuscript writing in Madura besides the focuses on the codicology found in al-Quran manuscript MSS 4322 which has been collected in the National Library of Malaysia. This study uses a qualitative approach with philological methods. The findings show that the history of the writing of the Qurʾan in Madura took place in line with the arrival and spread of Islam in the region of Madura in the 15th century AD. Based on the codicological analysis it was found that this manuscript came from the country of Madura, Indonesia. This is because it was written in the manuscripts that Pangeran Jimat was ruler of Madura in the 18th century AD. The writing uses daluang paper with a naskhi style writing model. This research shows that the rasm used in the mashaf tends more to rasm Imlaʾi. The beautiful illumination is with the drawing of spiral leaves as a result of a combination of various colors. The findings show that the author submits a proposal so that this manuscript can be digitized as a scholarly heritage so that it will last for a long time and help the community to more easily access it in a digital form that is sustainable in nature. In conclusion, this manuscript of the Qurʾan is a masterpiece that will enhance the dignity and writings of previous scholars academically and more authoritatively to the digital generation, especially in the field of the Qurʾan.
Fathers Who Completed Their Sons’ Books: Qāssim bin Thābit bin Ḥazm Al-Saraqusṭī and His Father as a Model
Authors: Saad Kassem Ali , Shehade Mona Mostafa 
Published: April 2023

Abstract
Ḥadīth scholars excelled in continuing the efforts of their precedents by; completing their unfinished work, making up for missed ones, or by fathers completing their sons’ unfinished work; a noble service from the eldest to the books of the youngest. The first scholar known for this is Thābit bin Ḥazm al-Saraqusṭī who completed his son’s Qāssim unfinished book (al-Dalāʾil), when Qāssim died before completing it. This book is not only considered as the most valuable one among Gharīb al-Ḥadīth books in Andalusīya but, as one of the most important books in Gharīb al-Ḥadīth in general. The author based his book al-Dalāīyl on the previous work of Abī Ūbayd al-Qāssim bin Sallām and Ibn Qutayba’s known books in Gharīb al-Ḥadīth, adding to what they’ve missed. He followed their methodology starting with al-Ḥadīth al-Marfoūʿ, followed by al-Mawqūf, then al-Maqṭūʿ, and maintained the precursor’s approach in referencing. Several scholars benefited enormously from this book and classified it among their valued resources. Thābit bin Qāssim bin Thābit – the grandson – was the key narrator for this book, assisting in its spread.
On Revision and Reconstruction: A Discussion about the Founding Year of the Jin Dynasty and Related Questions
Authors: Qiu Jingjia 
Published: April 2023

Abstract
According to records in the Jinshi, Wanyan Aguda established the Jin dynasty and proclaimed himself emperor in the year 1115. He selected the dynastic name Da Jin and the era name Shouguo. Liu Pujiang’s publications, however, have raised serious doubts about the Jinshi version of the Jin dynasty’s founding narrative and sparked a scholarly debate on the matter. On the basis of Liu Pujiang’s research and by careful analysis of records on the founding of the Jin state in Song and Yuan dynasties documents and stone inscriptions, this article manages to restore a rough picture of the real history of the early Jin. On advice by his counsellor Yang Pu, Aguda established the Jin dynasty and declared himself emperor in the seventh year (1117) of the Tianqing period of the Liao. He proclaimed the dynastic name Da Jin and the era name Tianfu. The founding history of the Jin dynasty as described in the Jinshi should be considered the product of historical revision that occurred during the rewriting process of the Taizu shilu. The era name Shouguo was only created retrospectively.
On the Issue of Determining the Founding Year of the “Great Mongol Nation”
Authors: Chen Xiaowei 
Published: April 2023

Abstract
The exact date of creation of the “Great Mongolian Nation” has long been a controversial topic. This article will point out that, according to the history of Mongolia and the Yuan dynasty as described in The History of the Buddha, the name “Great Mongol Nation” was first used in the Xinwei year. Since the source of the historical materials used to compile the Fozu lidai tongzai most likely were related to manuscripts used in the compilation and revision of Taizu shilu earlier in the Yuan dynasty, this should be a fairly trustworthy source. It is therefore possible to infer that Genghis Khan coined the term “Yeke Mongγol Ulus” (i.e., Great Mongol Nation) in 1211. As this was also the year that the Mongols began their war with the Jin dynasty, the creation of the “Great Mongol Nation” was a political move closely related to then ongoing matters of now historical significance and – in terms of the eventual establishment of the Yuan dynasty by the Mongolians – it had both far-reaching political impact and important strategic significance.
A New Study of the Title of the Reigning Dynasty during the Pre-Qing Period
Authors: Lu Zhengheng , Huang Yinong 
Published: April 2023

Abstract
What was the title of the reigning dynasty from the time when Nurhachi assumed the title of “khan” to the time when Hong Taiji declared himself emperor? There remains controversy among scholars as to whether the title “Jin” 金 or “Later Jin” 後金 was used, or if both were in use during different periods. Based on voluminous historical sources dating to the pre-Qing period, which have been published and even digitized in recent years, in addition to conducting the first comprehensive search of relevant Manchu and Chinese sources as well as artifacts, the authors have confirmed that there is no conclusive evidence proving that “Later Jin” was once used as the title of the reigning dynasty. Based on over a hundred instances of official usage of the title “Jin,” the authors have also concluded that the title of the reigning dynasty remained “Jin” during the entire pre-Qing period and that “Tianming” (Mandate of Heaven) was not the title of an emperor’s reign.
Aristocratic Families in the Jianghuai Region during the Tang-Song Interregnum
Authors: Ng Pak-sheung 
Published: April 2023

Abstract
With an emphasis on the Jianghuai region, this article aims to study the activities of aristocratic families during the Tang-Song Interregnum. Some aristocratic families managed to survive but were no longer in a position to carry out the cultural functions they had performed during the Tang dynasty. Based on the discussions undertaken by the article, aristocratic families played no evident role in political and cultural domains during the reign of Yang Wu and the Southern Tang. As such, total disappearance of the political and cultural capabilities of this privileged class in the Jianghuai region may have already taken place prior to the founding of the Southern Tang.
The Gnostic Accusation
Authors: Barton Jason 
Published: April 2023

Abstract
Initiated almost 200 years ago, the accusation that G.W.F. Hegel’s philosophy qualifies as Gnostic has stood the test of time. Beginning with Ferdinand Christian Baur’s 1835 Die christliche Gnosis, thinkers have attempted to inextricably bind Hegel’s philosophical endeavors to the ancient form(s) of religious knowledge production known as ‘Gnosticism’. Two additional figures have surfaced more recently who also champion the Gnostic accusation, namely Eric Voegelin and James Lindsay. Voegelin’s 1968 Science, Politics, and Gnosticism as well as his 1972 ‘On Hegel: A Study in Sorcery’ seek to justify and legitimize the Gnostic accusation in unequivocal terms. Lindsay’s 2022 best-seller, Race Marxism, further perpetuates the charge of Gnosticism against Hegel. I aim to deal with each of these figures and their respective accusations in reverse chronological order, demonstrating how each of them must artificially construct Hegel as a Gnostic in order to successfully defend their accusations.
Panentheism, History and the Problem of Evil
Authors: Jampol-Petzinger Andrew M. 
Published: April 2023

Abstract
In this paper I consider the thought of two Jewish existentialists from the first half of the 20th century, showing how their critique of pantheistic and panentheistic thinking grounded novel ideas about politics, history and human thought. In place of a concept of history directed towards a teleological redemption of suffering in the future, Lev Shestov (1866–1938) and Benjamin Fondane (1898–1944) abandoned notions of philosophical rationality in order to avow a ‘reversal’ of history according to which historical suffering could be expiated through the unforeseeable powers of the divine. From here, I look at the work of a contemporaneous philosopher – Walter Benjamin (1892–1940) – for the way in which his own conception of history as ‘rescuing’ the past provides an alternative panentheism, one according to which political responsibility derives from a need to redeem God whose existence has been exiled throughout the mundane world.
Machine Learning Method for Road Vehicle Collected Data Analysis
Authors: Carvalho Mateus , Hangan Horia 
Published: April 2023

Abstract
A major challenge encountered in the development of systems exposed to weather stressors, such as autonomous vehicles and unstaffed aerial vehicles, is to ensure their proper functioning under adverse rain or snow conditions. Since the sensing of the surroundings by these vehicles relies on optical sensors such as lidars and cameras, it is essential to ensure the robustness of these systems from the early stages of the project. In this respect, experiments in climatic wind tunnels provide a solution for simulating the operating conditions that the autonomous vehicles will confront. This work proposes a method based on field measurements and unsupervised machine learning to faithfully reproduce in controlled environments real weather conditions captured during wintertime in Ontario, Canada. The purpose of this paper is not to investigate correlations between observed weather conditions and the characteristics of the precipitation encountered, but rather to establish a consistent method based on outdoor disdrometer data to identify critical parameters to be simulated in climatic wind tunnels. To achieve this goal, weather data such as temperature, relative humidity, and droplet size distribution were recorded at General Motors’s McLaughlin Advanced Technology Track (MATT) using an FD70 disdrometer and WXT530 weather transmitter, both manufactured by Vaisala, installed on a car provided by the Automotive Center of Excellent (ACE) team of the University of Ontario Institute of Technology. The implementation of the proposed method allowed the identification of precipitation clusters characterized by parameters of a theoretical model for particle size distributions fitted to the collected data.