bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding refugee and immigrant health literacy and beliefs toward antimicrobial resistance
Authors: Ladines-Lim Joseph , Scruggs Elizabeth , Adzemovic Tessa , Croxton Rachel , Romero Ron , Lukela Michael , Mehrotra Preeti , Patel Payal 
Published: September 2023

Background: Antimicrobial resistance (AMR) is a global health threat, particularly in refugee populations, due to challenges posed by migration. Little guidance has been provided by public health agencies regarding antimicrobial stewardship specific to this demographic. Studies have primarily focused on encampment areas abroad. We sought to better understand health literacy and beliefs regarding AMR in local refugee and immigrant populations in southeastern Michigan. Methods: From November 1, 2022 to March 10, 2023, we distributed an anonymous questionnaire to adult patients at four primary care clinics in Southeastern Michigan and made it available online. The questionnaire collected demographic information and used 5-point Likert scale responses regarding antibiotic use in children with symptoms of respiratory infection. We binarized the questions and responses to determine whether respondents provided the preferred response and added these to create an overall health literacy score, then used simple linear and multivariable linear regression modeling to identify demographic variables independently associated with the health literacy score. Chi-squared and Mann-Whitney tests were also performed where appropriate. Results: Immigrants and refugees/asylum-seekers from low or middle-income countries (group A, n = 109) were compared to native-born Americans and immigrants from high-income countries (group B, n = 171) with participants from 40 countries (Figure 1). Age distribution did not differ between groups, while group B had generally longer duration of living in the United States (Figure 2). Differences were found in other demographic categories except female gender, with group B reporting higher income, educational levels, and English ability (Figure 3). Simple linear regression revealed that all demographic variables except age significantly correlated with responses (Figure 4). Multivariable linear regression showed that female gender, educational level, and age correlated with greater health literacy, while being in group A trended towards significance with respect to correlating with lesser health literacy (Figure 5). Conclusions: Immigrants and refugees/asylum-seekers from LMICs demonstrated beliefs suggesting deficits in knowledge of AMR compared to native-born Americans and those from high-income countries, independent of other potentially confounding demographic characteristics. Female gender, educational level, and age independently correlated with greater health literacy. These results could inform future patient-centered antimicrobial stewardship educational interventions in certain target populations such as immigrants and refugees/asylum-seekers in the United States.Disclosures: None
Antimicrobial Stewardship in a Psychiatric Hospital: Opportunities for Improvement
Authors: Rozdilsky Melissa , Bryson-Cahn Chloe , Chan Jeannie , Jain Rupali , Lynch John , Martinez-Paz Natalia , Escobar Zahra Kassamali 
Published: September 2023

Background: Western State Hospital (WSH) is an 800-bed, state-owned psychiatric hospital in Washington State which services individuals in 20 counties. WSH provides services and inpatient treatment to patients referred via behavioral health providers and/or the civil court system. Because many patients are admitted with serious, long-term illness, WSH also provides primary care and addresses infectious syndromes encountered in admitted patients. In January 2016, WSH officially began their antimicrobial stewardship program (ASP). In 2017 WSH joined the UW Center for Stewardship in Medicine (UW-CSiM) to grow and optimize their ASP. Methods: The lead pharmacist at WSH participated in weekly hour-long education and tele-mentoring sessions through the UW-CSiM program. Educational materials were adapted from UW-CSiM didactics and delivered to providers during regular meetings and grand rounds. Daily pharmacist led prospective audit with feedback was conducted. Antibiotic use data were collected and measured by days of therapy (DOT) per 1000-patient days from pharmacy dispensing records from 2015 to 2022. Results: From 1/1/15 to 12/31/22, there was a consistent trend of decreasing antibiotic consumption annually. In particular, antibiotic use decreased by over 65% ranging from 35-43 DOT per 1000 patient-days in 2015 to 9-11 DOT per 1000 patient-days in 2022 (Figure 1). This translates to approximately 1000 antibiotic days of therapy in 2015 and 200 days of antibiotic therapy in 2022. As of 2022, the two most common antibiotics used were cephalexin and sulfamethoxazole/trimethoprim Conclusion: Although treating infections is not a principal focus of a psychiatric hospital, patients receiving care in inpatient psychiatric facilities do experience common infections and receive antibiotics during their stay. At WSH, initiation of an antimicrobial stewardship program was associated with sustained decrease in total antibiotic DOT over 7 years. These data highlight the impact of tele-education and tele-mentoring in infectious diseases and antimicrobial stewardship as a path to build a successful antimicrobial stewardship even without formal infectious diseases training. Our single center experience at a large psychiatric hospital demonstrates the use of antimicrobials in these facilities and the opportunity for a large impact of an antimicrobial stewardship program in inpatient psychiatric facilities.Disclosures: None.
Guide to assembling a successful K99/R00 application
Authors: Michaely Peter , Bielinski Suzette J. , Campbell Kenneth , D’Alessio Franco , Dean Delphine , Earley Yumei Feng , Paine Robert , Salama Guy , Peter Inga 
Published: September 2023

Abstract
The National Institutes of Health’s (NIH) K99/R00 Pathway to Independence Award offers promising postdoctoral researchers and clinician-scientists an opportunity to receive research support at both the mentored and the independent levels with the goal of facilitating a timely transition to a tenure-track faculty position. This transitional program has been generally successful, with most K99/R00 awardees successfully securing R01-equivalent funding by the end of the R00 period. However, often highly promising proposals fail because of poor grantsmanship. This overview provides guidance from the perspective of long-standing members of the National Heart, Lung, and Blood Institute’s Mentored Transition to Independence study section for the purpose of helping mentors and trainees regarding how best to assemble competitive K99/R00 applications.
Systemic Breaches of EU Environmental Law and Techniques of Judicial Engagement with Science: the Underused Potential of Infringement Proceedings
Authors: Eliantonio Mariolina 
Published: September 2023

AbstractEnvironmental law has long been an area of concern in terms of correct implementation and enforcement. In this context, the Commission’s enforcement focus has been on “systemic” breaches of environmental law (that is, breaches that form part of a pattern of individual breaches that, taken together, because of their repeated or widespread nature, have a significant effect on the environment). Proving the existence of such breaches in environmental law presents a number of peculiar features, because of the scientifically–loaded questions which underlie environmental legislation. The aim of this article is to relate the established approach of the CJEU towards scientific uncertainty to the specific situation in which the Commission asserts that a breach of EU environmental law has a systemic nature. It will show that, while the CJEU has been sensitive to the systemic nature of the claims brought forward by the Commission by using some of the procedural tools at its disposal, its general reticence to engage with the substantive claims at stake might have the potential to reduce the effectiveness of the infringement proceedings as a tool to adequately pursue systemic breaches of EU environmental legislation.
The Systemic Criterion in the Use of Infringement Proceedings
Authors: Prete Luca 
Published: September 2023

AbstractThe aim of the present contribution is to assess how infringement proceedings under Articles 258 to 260 TFEU have dealt with ‘systemic’ breaches of EU law by the Member States’ authorities. It will be argue that two, or possibly three, strands of case-law appear to specifically concern systemic breaches of EU law.
RADIOCARBON CONCENTRATION IN SUB-ANNUAL TREE RINGS FROM POLAND AROUND 660 BCE
Authors: Rakowski Andrzej Z , Pawlyta Jacek , Miyahara Hiroko , Krąpiec Marek , Molnár Mihály , Wiktorowski Damian , Minami Masayo 
Published: September 2023

ABSTRACTThe article presents results of measurements of radiocarbon (14C) concentration in sub-annual dendrochronologically dated tree rings of English oak (Quercus robur L.) from Grabie village near Kraków (southern Poland). Samples of early wood (EW) and late wood (LW) spanning the years 664–658 BCE. α-cellulose was extracted from each sample and their radiocarbon content was measured at the ATOMKI laboratory in Debrecen, Hungary. The EW and LW data confirm a prolonged increase in Δ14C values around 665–663 as was observed by Park et al. (2017), Rakowski et al. (2019), or Sakurai et al. (2020). In addition, we found that this event may consist of two relatively small events, as was proposed by Sakurai et al. (2020). Based on obtained in this and previous study data we estimate that the occurrence of the two events were between 665 and 664 BCE (Rakowski et al. 2019), and in late spring of 663 BCE (May–June, before beginning of LW formation).
Agency and the Arusha Declaration: Nyerere, NUTA, and Political Discourse in Tanzania, 1966–7
Authors: Bjerk Paul 
Published: September 2023

AbstractOpening its general meeting on 27 December 1966, the state-sponsored National Union of Tanganyika Workers, known as NUTA, proposed a combative response to a presidential commission's investigation into mismanagement in the union. The union's general secretary also issued an azimio (resolution) that prefigured much of the socialist rhetoric and policy prescriptions that appeared a month later in Tanzanian president Julius Nyerere's Azimio la Arusha (Arusha Declaration) that refined his policy of African Socialism or Ujamaa. Although the NUTA azimio circulated widely and was submitted to the Arusha party meeting, it was excluded from both the record of that meeting and NUTA's own file of related material. This elision happened before its main author, NUTA general secretary Michael Kamaliza, was convicted of treason two years later. The suppression of NUTA's azimio offers a point of entry to investigate the diffuse agency of political rhetoric and the history of Nyerere's influential speech.
Identification and evaluation of important agronomic traits in 44 Polish wheat varieties (Triticum polonicum L.) grown on the Qinghai Plateau, China
Authors: Zhao Caixia , Shen Jicheng , Lv Shikai , Ye Fahui , Yin Shuxiang , Yang Miaosi , Liu Ruijuan , Liu Demei , Zhang Huaigang , Shen Yuhu , Chen Wenjie 
Published: September 2023

AbstractThe lack of excellent wheat germplasm resources on the Qinghai-Tibet Plateau has led to a gradual decrease in genetic diversity and an increasingly narrow genetic background in wheat grown in this region. Rational use of excellent genes from wheat relatives is important to increase genetic diversity, broaden the genetic base and achieve high yield and quality in common wheat. The objective of this study was to use principal component and cluster analyses of 13 important agronomic traits of 44 Polish wheat varieties over 3 years and comprehensively evaluate them to screen for excellent germplasm resources, thus providing the basic material for broadening the genetic base of Qinghai-Tibet Plateau wheat germplasm resources.
DECIDABLE FRAGMENTS OF THE QUANTIFIED ARGUMENT CALCULUS
Authors: PAVLOVIĆ EDI , GRATZL NORBERT 
Published: September 2023

AbstractThis paper extends the investigations into logical properties of the quantified argument calculus (Quarc) by suggesting a series of proper subsystems which, although retaining the entire vocabulary of Quarc, restrict quantification in such a way as to make the result decidable. The proof of decidability is via a procedure that prunes the infinite branches of a derivation tree in what is a syntactic counterpart of semantic filtration. We demonstrate an application of one of these systems by showing that Aristotle’s assertoric syllogistic is embeddable within, thus also providing another method of showing its decidability.
Use of Shallow Ice Core Measurements to Evaluate and Constrain 1980–1990 Global Reanalyses of Ice Sheet Precipitation Rates
Authors: Schneider Adam , Zender Charles , Loeb Nicole , Price Stephen 
Published: September 2023

AbstractSea‐level rise (SLR) projections by Earth System Models (ESMs) depend on ice sheet surface mass balances. Accurate, global atmosphere reanalyses would be ideal for providing equilibrated ice sheet model initial conditions in fully coupled ESM simulations. Here we present the first evaluation of 1980–1990 global reanalysis precipitation over Greenland and Antarctica that uses independent observations of net accumulation rates derived from shallow ice cores. Precipitation distributions from both the European Centre for Medium‐Range Weather Forecast's Reanalysis (ERA5) and the Modern‐Era Retrospective Analysis for Research and Applications (MERRA‐2) are highly correlated with contemporaneous co‐located net accumulation rates from Greenland (r2 > 0.95) and West Antarctica (r2 > 0.7). Three other commonly used reanalyses (WFDE5, CRUNCEP, and GSWP3) exhibit significantly weaker correlations on one or both ice sheets. Our findings imply that ESMs should use ERA5 or MERRA‐2 in data‐forced simulations to validate ice sheet model dynamics and precondition firn for SLR projections.
Signature of Two‐Step Non‐Linear Interactions Associated to Zonally Symmetric Waves During Major Sudden Stratospheric Warmings
Authors: Mitra G. , Guharay A. , Conte J. F. , Chau J. L. 
Published: September 2023

AbstractAtmospheric tides and associated dynamics during two major boreal sudden stratospheric warmings (SSWs) have been investigated. The evolutionary Lomb Scargle and wavelet spectral analysis of specular meteor radar (SMR)‐derived hourly winds reveal evidence of non‐linear interactions between the semidiurnal solar tide and the quasi‐20‐day wave (Q20dw) during SSWs. The zonal wavenumber (ZWN) diagnosis indicates possible non‐linear interaction between the dominant semidiurnal migrating tide (SW2) and zonally symmetric 20‐day wave (20dw0) component, producing the secondary waves. The non‐linear interaction between the ZWN 2 component of stationary planetary wave (SPW2) and westward propagating 20‐day wave (20dwW2) in the stratosphere seems crucial to produce the 20dw0. As observed in the SMR‐derived wind spectra, the excited 20dw0 possibly interacts non‐linearly with SW2 to generate secondary waves. Therefore, the present study provides the first observational evidence of a two‐step non‐linear interaction associated with zonally symmetric planetary waves during major SSWs.
mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia
Authors: Malik Natasha , Hay Jodie , Almuhanna Hassan N. B. , Dunn Karen M. , Lees Jamie , Cassels Jennifer , Li Jiatian , Nakagawa Rinako , Sansom Owen J. , Michie Alison M. 
Published: September 2023

AbstractTargeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1 (mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia in a CLL model, resulting from a failure for haemopoietic stem/progenitor cells (HSPCs) to commit to the B cell lineage. Induction of Raptor-deficiency in NSG mice transplanted with Mx1-Raptor CLL progenitor cells (PKCα-KR-transduced HSPCs) after disease establishment revealed a reduction in CLL-like disease load and a significant increase in survival in the mice. Interestingly in an aggressive CLL-like disease model, rapamycin treatment reduced disease burden more effectively than AZD2014 (dual mTORC1/2 inhibitor), indicating a skew towards mTORC1 sensitivity with more aggressive disease. Rapamycin, but not ibrutinib, efficiently targeted the eEF2/eEF2K translation elongation regulatory axis, downstream of mTORC1, resulting in eEF2 inactivation through induction of eEF2T56 phosphorylation. mTOR inhibitor treatment of primary patient CLL cells halted proliferation, at least in part through modulation of eEF2K/eEF2 phosphorylation and expression, reduced protein synthesis and inhibited expression of MCL1, Cyclin A and Cyclin D2. Our studies highlight the importance of translation elongation as a driver of disease progression and identify inactivation of eEF2 activity as a novel therapeutic target for blocking CLL progression.
Machine learning assisted vector atomic magnetometry
Authors: Meng Xin , Zhang Youwei , Zhang Xichang , Jin Shenchao , Wang Tingran , Jiang Liang , Xiao Liantuan , Jia Suotang , Xiao Yanhong 
Published: September 2023

AbstractMultiparameter sensing such as vector magnetometry often involves complex setups due to various external fields needed in explicitly connecting one measured signal to one parameter. Here, we propose a paradigm of indirect encoding for vector atomic magnetometry based on machine learning. We encode the three-dimensional magnetic-field information in the set of four simultaneously acquired signals associated with the optical rotation of a laser beam traversing the atomic sample. The map between the recorded signals and the vectorial field information is established through a pre-trained deep neural network. We demonstrate experimentally a single-shot all optical vector atomic magnetometer, with a simple scalar-magnetometer design employing only one elliptically-polarized laser beam and no additional coils. Magnetic field amplitude sensitivities of about 100 $${{{{{{{\rm{fT}}}}}}}}/\sqrt{{{{{{{{\rm{Hz}}}}}}}}}$$
fT
/

Hz

and angular sensitivities of about $$100 \sim 200\,\mu rad/\sqrt{{{{{{{{\rm{Hz}}}}}}}}}$$
100
~
200

μ
r
a
d
/

Hz

(for a magnetic field of around 140 nT) are derived from the neural network. Our approach can reduce the complexity of the architecture of vector magnetometers, and may shed light on the general design of multiparameter sensing.
Costs and health benefits of the rural energy transition to carbon neutrality in China
Authors: Ma Teng , Zhang Silu , Xiao Yilong , Liu Xiaorui , Wang Minghao , Wu Kai , Shen Guofeng , Huang Chen , Fang Yan Ru , Xie Yang 
Published: September 2023

AbstractThe rural energy transition is critical in China’s efforts to achieve carbon neutrality and improve air quality. However, the costs and health benefits associated with the transition to carbon neutrality remain unclear. Here we explore the cost-effective transition pathways and air quality-related health impacts using an integrated energy-air quality-health modeling framework. We find that decarbonizing rural cooking and heating would triple contemporary energy consumption from 2014 to 2060, considerably reducing energy poverty nationwide. By 2060, electric cooking ranges and air-to-air heat pumps should be widely integrated, costing an additional 13 billion USD nationally in transformation costs, with ~40% concentrated in Shandong, Heilongjiang, Shanxi and Hebei provinces. Rural residential decarbonization would remarkably improve air quality in northern China, yielding substantial health co-benefits. Notably, monetized health benefits in most provinces are projected to offset transformation costs, except for certain relatively lower-development southwestern provinces, implying more financial support for rural residents in these areas will be needed.
Multi-omics profiling reveals rhythmic liver function shaped by meal timing
Authors: Huang Rongfeng , Chen Jianghui , Zhou Meiyu , Xin Haoran , Lam Sin Man , Jiang Xiaoqing , Li Jie , Deng Fang , Shui Guanghou , Zhang Zhihui , Li Min-Dian 
Published: September 2023

AbstractPost-translational modifications (PTMs) couple feed-fast cycles to diurnal rhythms. However, it remains largely uncharacterized whether and how meal timing organizes diurnal rhythms beyond the transcriptome. Here, we systematically profile the daily rhythms of the proteome, four PTMs (phosphorylation, ubiquitylation, succinylation and N-glycosylation) and the lipidome in the liver from young female mice subjected to either day/sleep time-restricted feeding (DRF) or night/wake time-restricted feeding (NRF). We detect robust daily rhythms among different layers of omics with phosphorylation the most nutrient-responsive and succinylation the least. Integrative analyses reveal that clock regulation of fatty acid metabolism represents a key diurnal feature that is reset by meal timing, as indicated by the rhythmic phosphorylation of the circadian repressor PERIOD2 at Ser971 (PER2-pSer971). We confirm that PER2-pSer971 is activated by nutrient availability in vivo. Together, this dataset represents a comprehensive resource detailing the proteomic and lipidomic responses by the liver to alterations in meal timing.
Direct observation of topological magnon polarons in a multiferroic material
Authors: Bao Song , Gu Zhao-Long , Shangguan Yanyan , Huang Zhentao , Liao Junbo , Zhao Xiaoxue , Zhang Bo , Dong Zhao-Yang , Wang Wei , Kajimoto Ryoichi , Nakamura Mitsutaka , Fennell Tom , Yu Shun-Li , Li Jian-Xin , Wen Jinsheng 
Published: September 2023

AbstractMagnon polarons are novel elementary excitations possessing hybrid magnonic and phononic signatures, and are responsible for many exotic spintronic and magnonic phenomena. Despite long-term sustained experimental efforts in chasing for magnon polarons, direct spectroscopic evidence of their existence is hardly observed. Here, we report the direct observation of magnon polarons using neutron spectroscopy on a multiferroic Fe2Mo3O8 possessing strong magnon-phonon coupling. Specifically, below the magnetic ordering temperature, a gap opens at the nominal intersection of the original magnon and phonon bands, leading to two separated magnon-polaron bands. Each of the bands undergoes mixing, interconverting and reversing between its magnonic and phononic components. We attribute the formation of magnon polarons to the strong magnon-phonon coupling induced by Dzyaloshinskii-Moriya interaction. Intriguingly, we find that the band-inverted magnon polarons are topologically nontrivial. These results uncover exotic elementary excitations arising from the magnon-phonon coupling, and offer a new route to topological states by considering hybridizations between different types of fundamental excitations.