bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of the flow rate characteristics of porous media under the positive pressure and vacuum
Authors: Zhong Wei , Fu Kaiwen , Wang Yihao , Li Chong , Shao Jiang 
Published: August 2023

Abstract
Currently, porous media is widely used to replace the conventional orifices as restrictors in vacuum handling process. In this study, a theoretical model describing the flow rate characteristics, including effects from both viscosity and inertia, is established based on Darcy-Forchheimer’s law. The simulation work is firstly conducted, followed by establishing apparatuses to determine permeability and inertial coefficients. The permeability is determined within a small pressure difference (< 2 kPa) and the inertial coefficient is obtained with Re > 0.1 as the boundary. The average permeability is 1.21×10− 12 m2, 1.56×10− 12 m2, 3.41×10− 12 m2 and 12.21×10− 12 m2, respectively. The inertial coefficient is determined under the positive pressure at the maximum pressure difference and vacuum with pressure difference from 50 kPa to 70 kPa. For different pressure conditions, it is confirmed that the theoretical flow rate can predict the experimental data within a 3% uncertainty which is sufficient for most applications. Finally, to obtain the inertial coefficient, two methods including the single-point method and the multi-point method are proposed. We found that the single-point method gives an error of 3.1% while the multi-point method gives an error of 1.9% for the determination of the entire flow rate characteristics.
Resilience strengthening in youth with a chronic medical condition- a randomized controlled feasibility trial of a combined app and coaching program
Authors: Bischops Anne C. , Sieper Larissa , Dukart Jürgen , Schaal Nora K. , Reinauer Christina , Oommen Prasad T. , Tomoiaga Cristina , David Oana , Mayatepek Ertan , Meissner Thomas 
Published: August 2023

Abstract
Objective: Youth with a chronic medical condition (CMC) are often affected by comorbid mental disorders. Resilience-strengthening interventions can protect youth’s mental health, yet evidence-based programs remain scarce. To address this lack, this study aimed to evaluate the feasibility of a dual approach combining app-based resilience training and cognitive-behavioral group coaching.
Methods: 51 youths with CMC treated at a German university children’s hospital aged 12-16 years were recruited. They were randomly assigned to a combined app-game and coaching intervention or sole app gameplay. Pre-, postintervention and at a two-months follow-up resilience, automatic negative thoughts and an app and coaching evaluation were assessed. Feasibility was defined as a recruitment rate of ≥ 70%, an 85% adherence rate for the REThink app, and 70% participation in both coaching sessions.
Results: Feasibility criteria were reached for coaching participation but not for recruitment or app adherence. While both the REThink app and coaching intervention had high acceptance rates among youth with CMC, participants receiving additional coaching sessions showed higher satisfaction and adherence rates. Participants preferred remote to in-person meetings.
Conclusions: The findings support a combination of a gamification app-approach with online group coaching. Group coaching can improve adherence while online options increase accessibility. Future research should focus on testing in diverse participant samples, language and age-adapted updates of the REThink app. These findings provide guidance for increasing adherence in future intervention studies in youth with CMC cohorts.
Trial registration number: DRKS00027870, registered 24.01.2022.
The optimum number of induction chemotherapy cycles for N3M0 stage nasopharyngeal carcinoma based on pre-treatment plasma EBV DNA
Authors: Weng Youliang , Cai Sunqin , Li Chao , Xu Yun , Pan Yuhui , Huang Zongwei , Li Ying , Wu Zijie , Chen Yu , Qiu Sufang 
Published: August 2023

Abstract
Background
The objective of this study was to examine the significance of pre-treatment Epstein-Barr virus DNA (pre-DNA) in determining the optimal number of induction chemotherapy cycles (ICC) prior to concurrent chemoradiotherapy (CCRT) in patients with stage N3M0 nasopharyngeal carcinoma (NPC).
Methods
In this research, we used propensity score matching to divide enrolled patients into 3 cycles (IC = 3) or 4 cycles (IC = 4) group based on the number of ICC. To assess the disparity in survival and toxicities, the log-rank and chi-squared tests were employed, respectively. The main endpoint was distant metastasis-free survival (DMFS). Additional endpoints included overall survival (OS), progression-free survival (PFS), and locoregional relapse-free survival (LRRFS). Multivariate cox proportional hazard analysis identified potential independent prognostic factors.
Results
Of 369 patients, 194 were enrolled, with 97 and 97 included in IC = 3 and IC = 4 group respectively. The IC = 4 group exhibited markedly superior 3-year OS, PFS, DMFS, and LRRFS compared to the IC = 3 group (all p < 0.05), while experiencing higher adverse reactions, although not statistically significant. Based on DMFS, the cut-off value of pre-DNA was 8700 copies/ml (area under curve, 0.593; sensitivity, 0.794; specificity, 0.481). For low-risk patients with pre-DNA < 8700 copies/ml, both groups demonstrated comparable survival results. Nonetheless, the IC = 4 group exhibited better survival in 3-year OS, PFS, DMFS, and LRRFS compared to the IC = 3 group among high-risk patients with pre-DNA ≥ 8700 copies/ml (78.2% vs 49.1%, 69.1% vs 40.0%, 74.5% vs 40.0%, 70.9% vs 47.3%, all p < 0.05). Additionally, in high-risk group, ICC was considered as a protective element for OS and DMFS according to multivariate analysis.
Conclusions
For N3M0 stage NPC, pre-DNA could be a powerful predictor to guide the optimum number of ICC. IC = 4 was recommended for high-risk patients due to superior survival, while for low-risk patients, IC = 3 might be sufficient.
Psychometric properties of the Persian version of a novel short-form nutrition literacy measurement tool for nursing students
Authors: Mirzaei Alireza , Mojebi Mohammad Reza , Mostafazadeh Pouya , Jamshidinia Mobina , Nemati-Vakilabad Reza , Jafari Mohammad Javad 
Published: August 2023

Abstract
Background: Nutrition literacy (NL) encompasses knowledge and skills that can influence individuals' food choices. The present study aimed to translate and evaluate the psychometric properties of the Persian version of a novel short-form nutrition literacy (NL-SF12 (measurement tool for nursing students.
Methods: This study aimed to translate a novel short-form nutrition literacy measurement tool for nursing students into Persian. Subsequently, this version was used for psychometric evaluation. Face, content, and construct validity were assessed using confirmatory factor analysis. Internal consistency (Cronbach's alpha) and test-retest reliability (ICC) were calculated. Data were analyzed using SPSS and AMOS software.
Results: The results showed that NL-SF12 was successfully adapted into the Persian language, demonstrating face validity, content validity, convergent validity, and internal consistency for both the overall scale and its subscales. Confirmatory factor analysis indicated that the six-factor conceptual structure of the measure had a good fit. Reliability was assessed using internal consistency and test-retest stability. The Cronbach's alpha coefficient was 0.834 and the infraclass correlation coefficient (ICC) was 0.830.
Conclusion: The Persian version of the SF-12 questionnaire is a reliable and valid tool for measuring the health status. Therefore, it can be used for comprehensive assessment of the health status in nursing students.
Echocardiographic Profile of Cirrhotic Patients with Sepsis and Septic Shock: A Propensity Score Matched Case-Control Study
Authors: You Jee Young , Sato Ryota , Chawla Sanchit , Kapoor Aanchal , Wang Xiaofeng , Collier Patrick , Auzinger Georg , Duggal Abhijit , Dugar Siddharth 
Published: August 2023

Abstract
Background
Our understanding of changes in hemodynamics in cirrhotic patients with sepsis and septic shock and its impact on outcomes remains limited. Our study aims to investigate differences in hemodynamic profiles using echocardiography between septic patients with and without cirrhosis.
Methods
This is a single-center, retrospective study of septic patients with echocardiogram within 3 days of a medical intensive care unit (MICU) admission. We compared baseline characteristics, echocardiographic parameters, and outcomes between patients with and without cirrhosis. A propensity score-matched case-control model was developed to describe the differences in hemodynamic parameters between the groups.
Results
3,151 patients with sepsis and septic shock were included of which 421 (13%) had cirrhosis. In the propensity score model, cirrhotic patients had significantly higher left ventricular ejection fraction (63.4 vs. 56.2%, p < 0.001) and stroke volume (73.3 vs. 52.0 ml, p < 0.001) along with lower arterial elastance (Ea) (1.31 vs. 1.82, p < 0.001) and systemic vascular resistance (SVR) (1,110 vs. 1,370 dynes/sec/m− 5, p = 0.001). There was no difference between left ventricular elastance (Ees) (0.99 vs. 1.09, p = 0.107) and ventricular-arterial coupling (Ea/Ees) (1.29 vs. 1.40, p = 0.061).
Conclusion
Septic patients with cirrhosis had higher LVEF with a significantly higher percentage of hyperdynamic state than those without cirrhosis. Lower Ea and SVR without significant differences in Ees and Ea/Ees suggest vasodilation as the principal driver of the hyperdynamic profile in cirrhosis. This finding may facilitate tailored hemodynamic management focused on restoring vascular tone in cirrhotic septic patients.
Single-cell analysis extracted CAFs-related genes to established online app to predict clinical outcome and radiotherapy prognosis of prostate cancer
Authors: Lai Cong , Wu Zhikai , Li Zhuohang , Huang Xin , Hu Zhensheng , Yu Hao , Yuan Zhihan , Shi Juanyi , Hu Jintao , Mulati Yelisudan , Liu Cheng , Xu Kewei 
Published: August 2023

Abstract
Background
Cancer-associated fibroblasts (CAFs) play a significant role in regulating the clinical outcome and radiotherapy prognosis of prostate cancer (PCa). The aim of this study is to identify CAFs-related genes (CAFsRGs) using single-cell analysis and evaluate their potential for predicting the prognosis and radiotherapy prognosis in PCa.
Methods
We acquire transcriptome and single-cell RNA sequencing (scRNA-seq) results of PCa and normal adjacent tissues from The GEO and TCGA databases. The "MCPcounter" and "EPIC" R packages were used to assess the infiltration level of CAFs and examine their correlation with PCa prognosis. ScRNA-seq and differential gene expression analyses were used to extract CAFsRGs. We also applied COX and LASSO analysis to further construct a risk score (CAFsRS) to assess biochemical recurrence-free survival (BRFS) and radiotherapy prognosis of PCa. The predictive efficacy of CAFsRS was evaluated by ROC curves and subgroup analysis. Finally, we integrated the CAFsRS gene signature with relevant clinical features to develop a nomogram, enhancing the predictive accuracy.
Results
The abundance of CAFs exhibited a negative correlation with the prognosis of PCa. ScRNA-seq and differential gene expression analysis revealed 323 CAFsRGs. After COX and LASSO analysis, we obtained seven CAFsRGs with prognostic significance (PTGS2, FKBP10, ENG, CDH11, COL5A1, COL5A2, and SRD5A2). Additionally, we established a risk score model based on the training set (n = 257). The ROC curve was used to confirm the performance of CAFsRS (The AUC values for 1, 3 and 5-year survival were determined to be 0.732, 0.773, and 0.775, respectively.). The testing set (n = 129), GSE70770 set (n = 199) and GSE116918 set (n = 248) revealed that the model exhibited exceptional predictive performance. This was also confirmed by clinical subgroup analysis. The violin plot demonstrated a statistically significant disparity in the CAFs infiltrations between the high-risk and low-risk groups of CAFsRS. Further analysis confirmed that both CAFsRS and T stage were independent prognostic factors for PCa. The nomogram was then established and its excellent predictive performance was demonstrated through calibration and ROC curves. Finally, we developed an online prognostic prediction app (https://sysu-symh-cafsnomogram.streamlit.app/) to facilitate the practical application of the nomogram.
Conclusions
The prognostic prediction risk score model we constructed could accurately predict BRFS and radiotherapy prognosis PCa, which can provide new ideas for clinicians to develop personalized PCa treatment and follow-up programs.
Enviro-economic Optimization for the Design of Municipal Solid Waste Management Strategies
Authors: Puchongkawarin Channarong 
Published: August 2023

Abstract
A significant amount of municipal solid waste (MSW) generation and ineffective management can cause adverse impacts on the environment (air and water pollution) and human health. Therefore, a sustainable approach for handling MSW is required. The aim of this study is to develop a tool to select the most promising MSW management system using the superstructure optimization technique to ensure that the selected system can achieve minimization of the total annual cost and environmental impacts. This can lead to a multi-objective superstructure optimization problem which can be solved by using the augmented ε-constraint method. Then, the state of the art optimization solver can be used to solve the problem. The developed mathematical model is based on the concept of material balance and all potential technologies include anaerobic digestion, pyrolysis, gasification, incineration, sanitary landfill, material recovery facility and composting. The proposed methodology is applied to synthesize the MSW management system in Warin Chamrap district to determine its applicability. In this research, the composition of MSW include organics, paper, plastic, glass, and others. The results show that the Pareto-optimal solutions optimizing both total annualcost and environmental impacts can be developed. The MSW management system with the lower total annual cost tends to have the higher environmental impacts and the trade offs between each objective can be identified so the decision makers are able to consider before making their decision. Further investigation on sensitivity analysis reveals that the selling prices of products, annual capital cost and operating cost factors have different degree of impacts on the waste management strategies and total annual cost.
Suspension Training Improves the Muscle Quality of Older Adults
Authors: Medalha Ricardo Alessandro , Soligon Samuel Domingos , Silva Deivid Gomes , Bergamasco João Guilherme Almeida , Dias Nathalia Fernanda , Nóbrega Sanmy Rocha , Angleri Vitor , Libardi Cleiton Augusto 
Published: August 2023

Abstract
Purpose The aim of this study was to assess the effect of suspension training (ST) on muscle quality (MQ) in older adults.Methods Twenty-two physically independent elderly men and women were recruited and assigned to ST or control groups (CON). The MQ of the upper limbs (UL) and lower limbs (LL) was established by a ratio between maximum dynamic strength and lean body mass (LBM), assessed through the 1RM test and dual-energy X-ray absorptiometry, respectively, before and after a 12-week intervention period. The significance level was set at P ≤ 0.05.Results The ST was able to promote increases in the strength of the UL and LL (P < 0.0001). However, only LBMUL increased after 12 weeks of ST (P = 0.031) compared to CON. ST increased MQ for both QMUL (P = 0.011) and MQLL (P < 0.0001), while the CON group did not show any significant changes (P > 0.05).Conclusion these results indicate that ST can improve the MQ of older adults.
Construction of a novel prognostic risk model based on m6A-related miRNAs for acute myeloid leukemia
Authors: Chen Shuyi , Xu Xiaoli , Mo Jierong , Chen Yimin , Yuan Danyun , He Lang , Li Anqiao , Zhang Heng , Xu Lihua , Zhao Ying 
Published: August 2023

Abstract
N6-methyladenosine (m6A) modification and miRNAs were important in tumorigenesis and development. We aim to identify prognostic markers and construct a risk prediction model for AML patients. First, 17 prognostic m6A-related miRNAs were filtrated, whose expression profiles were included to cluster patients into 2 subtypes. The OS of cluster1 had worse prognosis. GSEA analysis showed cluster1 enriched in tumor-related pathways, including Toll like receptor signaling pathway, PPAR signaling pathway and apoptosis. Next, 10 miRNAs filtered by LASSO regression analysis were used to construct a risk model. Patients in high-risk groups had unfavorable prognosis and risk score might could act as the independent prognostic factors in AML. The expression of immune checkpoints (PD-L1, LAG-3 and CTLA4) were higher in high-risk group. Finally, we built a regulatory network of m6A regulators- m6A-related miRNAs- target mRNAs. The GO function analysis showed the target genes were enriched in the biological process related with leukemia, including tissue morphogenesis, regulation of leukocyte migration, positive regulation of cell adhesion and so on. The KEGG pathway analysis indicated that these genes were mainly enriched in Ras signaling pathway and signaling pathways regulating pluripotency of stem cells. The finding provided novel implication for efforts to improve the treatment of AML.
Developing a Novel Immune-Related two-Gene Signature and Immune Infiltration Pattern in Patients with psoriasis and chronic kidney disease
Authors: yin Tingting , zhang zhijun , Ma lei 
Published: August 2023

Abstract
Individuals with severe psoriasis (Ps) are at increased risk of developing chronic kidney disease (CKD), and conversely, CKD may contribute to the development of Ps. However, despite such an association between Ps and CKD, this relationship has not been fully elucidated. Therefore, there is a need for an in-depth study of the interactions between biomolecules and immunomarkers, as such associations may form the basis for identifying reliable diagnostic and monitoring methods for the disease. The goal of this study was to explore the potential relationship between Ps and biomarkers associated with CKD risk. First, we identified 74 common genes shared between Ps and CKD. These genes showed common transcriptional profiles in patients with Ps and CKD, and further functional analyses highlighted the key roles of inflammatory activation and innate immune response in the development of Ps and CKD. In addition, PPI networks and modules were constructed based on these genes, and four hub genes were screened using seven topological algorithms. Further analyses revealed altered immune responses common to patients with Ps and CKD. We identified two core immune-related genes (HIRGs), MX1 and DDX58, which were positively associated with macrophage and mast cell changes. Single-cell analysis revealed significantly increased expression of MX1 and DDX58 in T cells from patients with Ps and CKD. MX1 and DDX58 are involved in regulating the immune microenvironment and may induce inflammatory responses and immune dysfunction through T cell activation, which ultimately leads to the development of Ps and CKD. These two pivotal genes, MX1 and DDX58, may provide a new direction for breakthroughs in the clinical diagnosis and treatment of Ps combined with CKD.
Navigating the Gastric Cancer Maze: Embracing Laparoscopic D2 Lymphadenectomy for Safer and Faster Treatment: A retrospective cohort study
Authors: Bharati Vikeerna , Poddar Kallol Kumar Das , Sahoo Manas Ranjan , Shastri Shriganesh 
Published: August 2023

Abstract
Objective: This retrospective comparative study aimed to evaluate the feasibility and outcomes of laparoscopic subtotal gastrectomy (LSG) with D2 lymphadenectomy compared to open subtotal gastrectomy (OSG) for distal gastric adenocarcinoma.
Methods:A total of 42 patients with biopsy-proven distal gastric adenocarcinoma underwent either LSG or OSG with D2 lymphadenectomy at AIIMS Bhubaneswar, India, from March 2019 to July 2022. Baseline characteristics, operative parameters, postoperative outcomes, and one-year follow-up data were reviewed. Statistical analysis was performed using IBM SPSS Statistics 25.0.
Results: LSG was performed in 26 patients, with 4 cases (15.38%) requiring conversion to OSG due to technical challenges or bleeding. Both LSG and OSG groups were comparable in age, sex, BMI, comorbidities, and clinical stage. Neoadjuvant chemotherapy was administered to 86.4% and 85.0% of patients in LSG and OSG groups, respectively. The mean number of harvested lymph nodes in the LSG group was 20.77, meeting the AJCC criteria for radical gastrectomy. The mean operative time and blood loss were similar between the groups. LSG patients had significantly lower pain scores at 3 and 12 hours post-operation, faster resolution of postoperative ileus, and earlier mobilization compared to OSG. The incidence of postoperative complications was comparable between the groups, with no significant difference in disease-free survival after one year.
Conclusion: LSG with D2 lymphadenectomy is a feasible and safe option for resectable distal gastric adenocarcinoma, offering comparable outcomes to OSG. While the mean number of harvested lymph nodes in LSG was slightly lower than OSG, it still met the AJCC criteria. Careful patient selection and surgeon expertise are essential due to the potential need for conversion to open surgery. The impact of neoadjuvant chemotherapy on lymph node harvest rates in LSG cases warrants further investigation. The choice between LSG and OSG should be individualized based on patient factors and tumor characteristics.
Phylogeny of the tribe Sophoreae (Fabaceae, Faboideae) and taxonomy of Ammopiptanthus using plastome data
Authors: Lv Weiwei , Gao Yuchen , Qian Jiayi , Chai Xueping , Liu Luxian 
Published: August 2023

Abstract
Background
The tribe Sophoreae is one of the subdivisions of the plant family Fabaceae, previous studies relating on the phylogeny of the tribe Sophoreae were mainly limited to a small number of molecular markers, and Ammopiptanthus is a problematic taxonomic genus within the tribe Sophoreae.
Methods and results
We assembled three plastomes including two A. mongolicus and one A. nanus based genome skimming data. The plastomes of the two species are from 153 812 bp to 153 921 bp, with typical quadripartite structures containing a large single copy, a small single copy, and a pair of inverted repeats. Comparative genomic analyses show that the plastomes of the tribe Sophoreae are relatively conserved. Phylogenetic analyses based on plastomes of the tribe Sophoreae indicate that all the species are divided into three clades, two genera including Thermopsis and Sophora are recovered as non-monophyletic. Multiple individuals of A. mongolicus and A. nanus are intraspecific monophyletic with full support in the phylogenetic tree, confirming that A. nanus should be treated as a distinct species within Ammopiptanthus.
Conclusions
In this study, we conducted genome skimming of three individuals including two A. mongolicus and one A. nanus. Combined with previously published data, the phylogeny of the tribe Sophoreae was investigated and the taxonomy of Ammopiptanthus was fully resolved by plastome data.