bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the use of empiric antimicrobial prophylaxis for temporary cardiac devices at a large academic medical center
Authors: Kim Ju Hee , Mason Jessica , Toyoda Alexander Y , Ji Christine S , Gandhi Ronak G , Solomon Edmond J 
Published: June 2023

Introduction Varying rates of access site infections with temporary percutaneous cardiac devices have been reported in the literature. The purpose of this study is to determine the impact of a change in institutional practice in utilizing antimicrobial prophylaxis to prevent access site infections in patients with these devices. Methods This observational, pre-post implementation analysis evaluated the benefit of prophylactic antimicrobial therapy in adult patients with temporary percutaneous cardiac devices admitted to cardiac intensive care units. Patients in the pre-cohort received prophylactic antibiotics for the duration of device insertion. Patients in the post-cohort received a single dose of intravenous antibiotics for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or Impella® 5.5 device placement, and no antimicrobial prophylaxis for all other devices placed. The primary endpoint was the incidence of definitive access site infection. Secondary endpoints included the incidence of Clostridium difficile infection and initiation of broad-spectrum antibiotics. Results Fifty patients in the pre-cohort and 45 patients in the post-cohort were evaluated. Devices included intra-aortic balloon pumps, VA-ECMO, Impella® CP and Impella® 5.5. The median duration of device insertion was four days. No significant difference in the primary outcome was seen between the two groups. A significant reduction in prophylactic antimicrobial utilization and total days of antimicrobial exposure was observed in the post-implementation cohort. Conclusion Based on the results of our study, the implemented guideline reduces the utilization of antimicrobial prophylaxis in patients with temporary percutaneous cardiac devices and does not result in an increased rate of infections.
Spanish consensus of occupational therapists on upper limb assessment tools in stroke
Authors: Madroñero-Miguel Beatriz , Cuesta-García César 
Published: June 2023

Introduction:There is a lack of explicit tool recommendations for upper limb (UL) assessment in stroke, occupational therapists are frequently underrepresented in consensus studies, and the frequency of use of tools is highly variable between countries. The objective was to generate national occupational therapy consensus recommendations on UL assessment tools in stroke, and to classify the tools that achieve consensus according to the International Classification of Functioning, Disability and Health (ICF) components.Methods:Three-round e-Delphi study of national scope. Occupational therapists working in Spain with training and experience in neurorehabilitation were recruited. Rounds were based on the completion of questionnaires on UL stroke assessment tools. Consensus was reached when ⩾75% of experts gave a ⩾7 rating on a nine-point Likert scale.Results:A total of 29 occupational therapists comprised the expert panel. Twenty-three (17.8%) assessment tools achieved consensus and were classified according to the ICF components of body functions and structures (7), activities (11), participation (3) and other (2).Conclusion:The expert panel recommended 23 outcome measures for UL recovery in stroke, representing all ICF components. The consensus recommendations are intended to assist occupational therapists in their clinical decision-making process, and to reduce the heterogeneity of research tools.
Sexualized drug use and STD and HIV incidence among men who have sex with men in Amsterdam, the Netherlands
Authors: Blomaard Carien M , Jongen Vita W , Achterbergh Roel CH , van der Loeff Maarten F Schim , de Vries Henry JC 
Published: June 2023

Background We assessed the association between sexualized drug use (SDU), and incident sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV) infections among men who have sex with men (MSM). Methods We used data from the MS2 cohort study, conducted at the STI Outpatient Clinic of the Public Health Service of Amsterdam, the Netherlands, in 2014–2019. Eligible participants were adult HIV-negative MSM with ≥2 STDs in the preceding year and MSM living with HIV and ≥1 STD. Participation encompassed 3-monthly visits including STD screening and questionnaires on drug use. Primary outcomes were incident HIV, anal chlamydia/gonorrhoea, and syphilis. We studied the association between SDU of individual drugs and incident HIV and STDs, using Poisson regression. Analyses were adjusted for age and HIV-status. Results 131 HIV-negative MSM and 173 MSM living with HIV were included for analysis. SDU with GHB/GBL (aIRR = 7.2, 95% CI = 1.4–35.5) in the 3 months before testing was associated with incident HIV. SDU with GHB/GBL (aIRR = 1.2, 95% CI = 1.0–1.4), ketamine (aIRR = 1.3, 95% CI = 1.0–1.6) or methamphetamine (aIRR = 1.3, 95% CI = 1.0–1.6) was associated with incident anal chlamydia/gonorrhoea. We found no association between SDU with specific drug types and syphilis incidence. Conclusions SDU with GHB/GBL, ketamine and methamphetamine among MSM was associated with incident HIV and anal chlamydia/gonorrhoea. HIV-negative MSM engaging in SDU should be advised to use HIV pre-exposure prophylaxis, and all MSM engaging in SDU should be advised to have STD screening regularly. We suggest counselling on STDs among MSM engaging in SDU.
Beyond home language: Heritage language maintenance practices of Yorùbá–English bilingual immigrants
Authors: Kupolati Oluwateniola Oluwabukola 
Published: June 2023

Purpose:This research investigates the heritage language (HL) as a core value of first-generation Yorùbá English bilingual immigrants in the United States and explicates HL maintenance practices among them.Methodology:It uses observation and semi-structured interviews with first-generation Yorùbá–English bilingual immigrants residing in New York, Texas and Maryland.Data and analysis:Transcripts from the interviews and field notes from the observation were analysed and coded using Reflexive Thematic Analysis (RTA) and some features of the Interlinear Morpheme Glossing (IMG) rules which are conventions useful for transliterations and translations.Findings:The heritage language is the distinctive identity of first-generation Yorùbá–English bilingual immigrants in the United States. Hence, they adopt maintenance strategies similar to those of other immigrants identified in previous studies (home language, language of familiarity, language as code and language for admonition) and devise ingenious strategies to ensure maintenance including language for setting intergroup boundaries, language for maintaining connectedness and language for naming realities.Originality:Previous studies have examined HL maintenance among Asian, Hispanic and European immigrants who have HLs with high numeric strength, but this study examines immigrants of African descent and an HL with low numeric strength. It also presents unobserved HL maintenance strategies which are peculiar to first-generation Yorùbá–English bilingual immigrants in the United States.Implications:Despite English monism, immigrants/ethnic minorities can go beyond common HL maintenance strategies and create unique ones that will ensure the continued use of their languages. The ability to do this advances a positive ethnic identity, guarantees an improved lifespan for HLs in host communities and reduces instances of identity crisis among immigrants.
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord
Authors: Ahlström Fredrik HG , Viisanen Hanna , Karhinen Leena , Mätlik Kert , Blomqvist Kim J , Lilius Tuomas O , Sidorova Yulia A , Palada Vinko , Rauhala Pekka V , Kalso Eija A 
Published: June 2023

Background: Opioids are efficacious and safe analgesic drugs in short-term use for acute pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial activation may contribute to the development of tolerance and this process may differ between males and females. A link is suggested between this microglial activation and inflammation, disturbances of circadian rhythms, and neurotoxic effects. We set out to further delineate the effects of chronic morphine on pain behaviour, microglial and neuronal staining, and the transcriptome of spinal microglia, to better understand the role of microglia in the consequences of long-term high-dose opioid administration. Experimental Approach: In two experiments, we administered increasing subcutaneous doses of morphine hydrochloride or saline to male and female rats. Thermal nociception was assessed with the tail flick and hot plate tests. In Experiment I, spinal cord (SC) samples were prepared for immunohistochemical staining for microglial and neuronal markers. In Experiment II, the transcriptome of microglia from the lumbar SC was analysed. Key Results: Female and male rats had similar antinociceptive responses to morphine and developed similar antinociceptive tolerance to thermal stimuli following chronic increasing high doses of s.c. morphine. The area of microglial IBA1-staining in SC decreased after 2 weeks of morphine administration in both sexes. Following morphine treatment, the differentially expressed genes identified in the microglial transcriptome included ones related to the circadian rhythm , apoptosis, and immune system processes. Conclusions: Female and male rats showed similar pain behaviour following chronic high doses of morphine. This was associated with decreased staining of spinal microglia, suggesting either decreased activation or apoptosis. High-dose morphine administration also associated with several changes in gene expression in SC microglia, e.g., those related to the circadian rhythm ( Per2, Per3, Dbp). These changes should be considered in the clinical consequences of long-term high-dose administration of opioids.
A systematic review to identify and collate factors influencing patient journeys through clinical trials
Authors: Dobra Rebecca , Wilson Gemma , Matthews Jessie , Boeri Marco , Elborn Stuart , Kee Frank , Davies Jane C , Madge Susan 
Published: June 2023

Summary Patient-centred trial design and delivery; improves recruitment and retention; increases participant satisfaction; encourages participation by a more representative cohort; and allows researchers to better meet participants’ needs. Research in this area mostly focusses on narrow facets of trial participation. We aimed to systematically identify the breadth of patient-centred factors influencing participation and engagement in trials, and collate them into a framework. Through this we hoped to assist researchers to identify factors that could improve patient-centred trial design and delivery. Robust qualitative and mixed methods systematic reviews are becoming increasingly common in health research. The protocol for this review was prospectively registered on PROSPERO, CRD42020184886. We used the SPIDER (Sample, Phenomenon of Interest, Design, Evaluation, Research Type) framework as a standardised systematic search strategy tool. 3 databases were searched as well as references checking, and thematic synthesis was conducted. Screening agreement was performed and code and theme checking were conducted by 2 independent researchers. Data were drawn from 285 peer-reviewed articles. 300 discrete factors were identified, and sorted into 13 themes and subthemes. The full catalogue of factors is included in the Supplementary Material . A summary framework is included in the body of the article. This paper focusses on outlining common ground that themes share, highlighting critical features, and exploring interesting points from the data. Through this, we hope researchers from multiple specialities may be better able to meet patients’ needs, protect patients’ psychosocial wellbeing, and optimise trial recruitment and retention, with direct positive impact on research time and cost efficiency.
Is Belonging Stable Over Time?: A Four-Year Longitudinal Examination of University Belonging Differences Among Students
Authors: Ruedas-Gracia Nidia , Jiang Ge , Maghsoodi Amir H. 
Published: June 2023

Sense of belonging is crucial for thriving in various contexts and must be maintained over time. However, we know little about how belonging fluctuates. In education, changes in school belonging differ by gender identity. Unfortunately, this evidence does not assess differences by racial identity or socioeconomic status. Because low belonging among students that espouse minoritized racial socioeconomic identities is a pervasive concern, it is important to understand how it functions among diverse groups. Via growth curve modeling this study explores changes in university belonging among individuals (Ns = 136, MT1age = 19 years) from diverse backgrounds (Black 16%, Latinx 15%, Asian 19%, White 34%, Native American 3%, Multiracial 13%; 36% low-income; 61% female identifying) over 4 years of college.
Impact of Individual Spinopelvic Anatomy on the Localization and Severity of Symptomatic Isthmic Spondylolisthesis
Authors: Labbus Kirsten , Bürger Justus , Löchel Jannis , Schäfer Frederik Maximilian , Putzier Michael , Zahn Robert Karl 
Published: June 2023

Study Design Retrospective analysis of prospectively collected data. Objectives Isthmic spondylolisthesis (iSPL) occurs most commonly in L5/S1 and L4/5. This study investigates the association between spinopelvic anatomy and the pathogenesis of iSPL. Methods Spinopelvic parameters as well as severity of slip grade were measured in sagittal spine radiographs of symptomatic patients with iSPL in segments L4/5 and L5/S1. Means were calculated and differences between both groups were analyzed. A correlation between the analyzed parameters and degree of slippage was performed. Results We included 73 subjects in this study; 11 in L4/5 group and 62 in L5/S1 group. Pelvic anatomy significantly differed between L4/5 and L5/S1 iSPL (Pelvic Incidence (PI) 54.8° vs 66.3°, P value = .006; Pelvic Radius (PR) 124.4 mm vs 137.4 mm; P value = .005 and Sacral Table Angle (STA) 101.0° vs 92.2°, P value < .001). The relative degree of slippage was significantly higher in the L5/S1 group (L4/5 29.1% vs L5/S1 40.1%, P value .022). We also observed a significant correlation between pelvic anatomy and the severity of the slip in iSPL at the L5/S1 level. Conclusions Pelvic parameters PI and STA play an important role concerning the level of occurrence and severity of iSPL. Spinopelvic anatomy determines the pathogenesis of iSPL.
Best Practices for Use-Related Risk Analysis Through Collaboration of Human Factors and Clinical
Authors: Mehrzad Heidi M. , Stüdeli Thomas , Quie Helene 
Published: June 2023

Integrating the human factors engineering (HFE) process, and its user-centered approach, into the medical device and combination Product and Development Process (PDP), has been an ongoing challenge for its respective industries and Human Factors (HF) practitioners within it for decades. Yet, despite continuous process adaptation and evolution of the HFE process, as well as the introduction of standards and health authority guidelines, the early integration of a risk-based and user-centered approach within the development and design process remains an ongoing practical challenge occupying the minds of most. With the introduction of the European MDR 2017/745 in 2017, an additional emphasis was put on the importance of use-related risk identification, assessment, and data based evaluation within the clinical evaluation process, and with such introduces clinical teams to (new) ‘use-related risk challenges’ as well. This paper provides a framework for early integration of an iterative use-related risk analysis approach, addressing common practical challenges, and providing best practices for such. Furthermore, it highlights how applying a collaborative approach between HF and clinical efforts would permit for collection of more robust use-related data sets, thus potentially optimizing use-related risk, residual risk, and risk-benefit analyses and their processes.
Evaluation of Spin in the Clinical Literature of Suture Tape Augmentation for Ankle Instability
Authors: Thompson Ashley A. , Hwang N. Mina , Mayfield Cory K. , Petrigliano Frank A. , Liu Joseph N. , Peterson Alexander B. 
Published: June 2023

Background: Spin is defined as the use of specific reporting strategies to highlight the beneficial effect of a treatment despite nonsignificant results. The presence of spin in peer-reviewed literature can negatively impact clinical and research practices. The purpose of this study was to identify the quantity and types of spin present in primary studies and systematic reviews using suture tape augmentation for ankle instability as a model. Methods: This study was conducted per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Each abstract was assessed for the presence of the 15 most common types of spin. Extracted data included study title, authors, publication year, journal, level of evidence, study design, funding, reported adherence to PRISMA guidelines, and PROSPERO registration. Full texts of systematic reviews were used in the assessment of study quality per A Measurement Tool to Assess Systematic Reviews Version 2 (AMSTAR 2). Results: Nineteen studies were included in the final sample. At least 1 type of spin was identified in each study except one (18 of 19, 94.7%). The most common type of spin observed was type 3 (“selective reporting or overemphasis on efficacy outcomes or analysis favoring the beneficial effect of the experimental intervention”) (6 of 19, 31.6%), The second most reported category of spin was type 4 (“the conclusion claims safety based on non-statistically significant results with a wide confidence interval”) (4 of 19, 21.1%). Among systematic reviews, we identified type 5 (“the conclusion claims the beneficial effect of the experimental treatment despite a high risk of bias in primary studies”) in 4 out of 6 (66.7%) of the articles that were included. No significant associations were found between study characteristics and type of spin. Conclusion: In this exploration of the introduction of a new technology, we identified spin to be highly present in the abstracts of primary studies and systematic reviews concerning suture tape augmentation for ankle instability. Steps should be taken by scientific journals to ensure that spin is minimized in the abstract to accurately reflect the quality of the intervention.
Reemployment premium effect of furlough programs: evaluating Spain’s scheme during the COVID-19 crisis
Authors: Garcia-Clemente J. , Rubino N. , Congregado E. 
Published: June 2023

AbstractThis paper presents an average treatment effect analysis of Spain’s furlough program during the onset of the COVID-19 pandemic. Using 2020 labour force quarterly microdata, we construct a counterfactual made of comparable nonfurloughed individuals who lost their jobs and apply propensity score matching based on their pretreatment characteristics. Our findings show that the probability of being re-employed in the next quarter significantly increased for the treated (furlough granted group). These results appear robust across models, after testing a wide range of matching specifications that reveal a reemployment probability premium of near 30 percentage points in the group of workers who had been furloughed for a single quarter. Nevertheless, a different time arrangement affected the magnitude of the effect, suggesting that it may decrease with the furlough duration. Thus, an analogous analysis for a longer (two quarter) scheme estimated a still positive but smaller effect, approximately 12 percentage points. Although this finding might alert against long lasting schemes under persistent recessions, this policy still stands as a useful strategy to face essentially transitory adverse shocks.
Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques
Authors: Liu Xu , Liu Xuyuan , Wang Xinqi , Shang Ke , Li Jiawei , Lan Yue , Wang Jiao , Li Jing , Yue Bisong , He Miao , Fan Zhenxin 
Published: June 2023

AbstractRhesus macaques (Macaca mulatta, RMs) are widely used in sexual maturation studies due to their high genetic and physiological similarity to humans. However, judging sexual maturity in captive RMs based on blood physiological indicators, female menstruation, and male ejaculation behavior can be inaccurate. Here, we explored changes in RMs before and after sexual maturation based on multi-omics analysis and identified markers for determining sexual maturity. We found that differentially expressed microbiota, metabolites, and genes before and after sexual maturation showed many potential correlations. Specifically, genes involved in spermatogenesis (TSSK2, HSP90AA1, SOX5, SPAG16, and SPATC1) were up-regulated in male macaques, and significant changes in gene (CD36), metabolites (cholesterol, 7-ketolithocholic acid, and 12-ketolithocholic acid), and microbiota (Lactobacillus) related to cholesterol metabolism were also found, suggesting the sexually mature males have stronger sperm fertility and cholesterol metabolism compared to sexually immature males. In female macaques, most differences before and after sexual maturity were related to tryptophan metabolism, including changes in IDO1, IDO2, IFNGR2, IL1Β, IL10, L-tryptophan, kynurenic acid (KA), indole-3-acetic acid (IAA), indoleacetaldehyde, and Bifidobacteria, indicating that sexually mature females exhibit stronger neuromodulation and intestinal immunity than sexually immature females. Cholesterol metabolism-related changes (CD36, 7-ketolithocholic acid, 12-ketolithocholic acid) were also observed in female and male macaques. Exploring differences before and after sexual maturation through multi-omics, we identified potential biomarkers of sexual maturity in RMs, including Lactobacillus (for males) and Bifidobacterium (for females) valuable for RM breeding and sexual maturation research.
Identification and validation of a DNA methylation-driven gene-based prognostic model for clear cell renal cell carcinoma
Authors: Deng Qiong , Du Ye , Wang Zhu , Chen Yeda , Wang Jieyan , Liang Hui , Zhang Du 
Published: June 2023

AbstractBackgroundClear cell renal cell carcinoma (ccRCC) is a malignant tumor with heterogeneous morphology and poor prognosis. This study aimed to establish a DNA methylation (DNAm)-driven gene-based prognostic model for ccRCC.MethodsReduced representation bisulfite sequencing (RRBS) was performed on the DNA extracts from ccRCC patients. We analyzed the RRBS data from 10 pairs of patient samples to screen the candidate CpG sites, then trained and validated an 18-CpG site model, and integrated the clinical characters to establish a Nomogram model for the prognosis or risk evaluation of ccRCC.ResultsWe identified 2261 DMRs in the promoter region. After DMR selection, 578 candidates were screened, and was correspondence with 408 CpG dinucleotides in the 450 K array. We collected the DNAm profiles of 478 ccRCC samples from TCGA dataset. Using the training set with 319 samples, a prognostic panel of 18 CpGs was determined by univariate Cox regression, LASSO regression, and multivariate Cox proportional hazards regression analyses. We constructed a prognostic model by combining the clinical signatures. In the test set (159 samples) and whole set (478 samples), the Kaplan–Meier plot showed significant differences; and the ROC curve and survival analyses showed AUC greater than 0.7. The Nomogram integrated with clinicopathological characters and methylation risk score had better performance, and the decision curve analyses also showed a beneficial effect.ConclusionsThis work provides insight into the role of hypermethylation in ccRCC. The targets identified might serve as biomarkers for early ccRCC diagnosis and prognosis biomarkers for ccRCC. We believe our findings have implications for better risk stratification and personalized management of this disease.