bluuebunny/crossref_metadata_2025_split huggingface dataset:
User-generated content on Gen Z tourist visit intention: a stimulus-organism-response approach
Authors: Yamagishi Kafferine , Canayong Danzel , Domingo Mariella , Maneja Kim Nieva , Montolo Angel , Siton Arabelle 
Published: September 2023

PurposeThis paper aims to explore the causal relationship of user-generated content (UGC) on trust in UGC (TUGC), destination image (DI) and tourist visit intention (VI) guided by the stimulus-organism-response (SOR) theory. This work further examined the mediating effect of TUGC and DI between UGC and VI.Design/methodology/approachData were collected through online and personal-administered surveys and randomized sampling. This work employed partial least squares structural equation modeling (PLS-SEM) to test the proposed model empirically.FindingsIn line with the SOR Theory, this work found UGCs that induce positive emotions and connection to the users motivate VI rather than UGCs that are predominantly factual. Furthermore, UGCs are considered reliable, authentic and less biased than brand-generated content. The findings of this work contribute to the theoretical understanding of UGC to VI in a destination.Practical implicationsThis work proposes that destination marketers prioritize UGC that evokes positive emotions and connections with users, as it is more effective in encouraging VI. Strategies such as incentivizing content creators, improving online presence and engaging influencers can maximize UGC. Enhancing online traffic quality, visibility and interaction and implementing content policies are crucial for UGC's effectiveness. Marketers should align destination products with tourists' interests and collaborate with influencers for affiliate marketing to increase tourist-generated UGC. Furthermore, improved connectivity encourages UGCs about the destination.Originality/valueIn tourism marketing, UGC has become a valuable information source for tourists in making informed travel decisions. UGC is a tourist-generated content that offers factual information and authentic experiences through images, videos or text posted through social media platforms. UGC is considered more reputable than travel firms and the mainstream media as an information source. Due to the limited works on UGC in the literature, the influence of UGC on tourists' VIs has remained unexplored at the time of writing. This work bridges this gap by empirically examining the impact of UGC on Gen Z tourists' VI guided by the SOR theory.
Innocence versus Coolness: the influence of brand personality on consumers’ preferences
Authors: Feng Wenting , Xu Yuanping , Wang Lijia 
Published: September 2023

PurposeBuilding on the theory of brand psychological ownership, this paper aims to explore the mediating role of brand psychological ownership in the relationship between brand personality (innocence/coolness) and consumers’ preferences, as well as identify the boundary conditions of this relationship.Design/methodology/approachTo test the hypotheses, a series of four experiments were conducted in Wuhan, a city in southern China, using questionnaires administered at two universities and two supermarkets. Hypotheses were tested using PLS-SEM in SmartPLS 4.FindingsThe results indicate that brand personality, specifically the dimensions of innocence and coolness, has a significant impact on consumers’ brand preferences. Brands with a cool personality are preferred over those with an innocent personality. Moreover, the relationship between brand personality and consumers’ brand preferences is moderated by power motivation and identity centrality.Originality/valueThis study contributes to the literature by differentiating between brand personality of innocence and coolness as two separate constructs and proposing brand psychological ownership as a mechanism through which brand personality affects brand preferences. The study’s samples were drawn from universities and supermarkets in southern China, providing evidence for the significant moderating effects of power motivation and identity centrality on consumers’ brand preferences.
Reflections on phygital experiences: conceptual boundaries, wellbeing benefits and methodological suggestions
Authors: Lee Dong-Jin , Yu Grace B. , Sirgy M. Joseph 
Published: September 2023

Purpose
The purpose of this paper is to reflect on the construct of phygital experiences and provide ideas that may spur future research on phygital consumer experiences in relation to consumer well-being using qualitative research methods.

Design/methodology/approach
With the increase in consumers’ online and offline interactions, there is a greater need for marketers to prompt integrated consumer experiences (i.e. integrated customer experiences through online and offline interactions). The authors developed this essay based on a literature review of phygital experiences and consumer well-being.

Findings
This commentary provides suggestions on how to expand the conceptual boundaries of phygital experiences by examining the effects of consumer phygital experiences in relation to consumer need satisfaction, consumer happiness and benefits to the firm. The commentary also includes several methodological suggestions that can guide future qualitative research.

Originality/value
The value of this commentary involves insights about research methods stimulated by the current research on consumer well-being.
Relative contribution of season, site, scion and rootstock genotype, and susceptibility to European canker to the variability in bacterial and fungal communities in apple leaf scar tissues
Authors: Papp‐Rupar Matevz , Deakin Greg , Olivieri Leone , Robinson‐Boyer Louisa , Xu Xiangming 
Published: September 2023

AbstractNeonectria ditissima infects apple trees through wounds, causing European canker. In the UK, the most important entry site for N. ditissima is leaf scar. Specific apple endophytes may contribute to cultivar resistance/tolerance to the pathogen. We assessed the relative effect of location, sampling time (season), and rootstock/scion genotype on bacterial and fungal endophyte communities in the apple leaf scar tissues of current‐season extension shoots and identified Operational Taxonomic Units (OTUs) with differential abundance between canker resistant and susceptible scions, and between rootstocks. Leaf scar tissues were sampled from two orchards at three times (10/2018, 06/2019 and 10/2019) for eight scion cultivars, each grafted onto two rootstocks, for profiling 16S and ITS rRNA regions. Endophyte composition was primarily affected by season (autumn vs. spring) and location (sites and blocks within site). There was a significant reduction in the community size in the spring, particularly for fungi, and species turnover between autumn and spring. This seasonal dynamics suggest that to protect leaf scars from N. ditissima infection in the autumn specific endophytes suppressing canker may have to be augmented annually around the leaf‐fall time. Scion and rootstock genotypes had limited effects on the endophyte community. A group of resistant cultivars differed from a group of susceptible ones in the relative abundance of many bacterial and fungal OTUs, most of which had low reads numbers. Nevertheless, several OTUs with high reads numbers differed in their relative abundance between resistant and susceptible scions, including OTUs from Sphingomonas, Methylobacterium, Vishniacozyma and Rhodotorula babjevae, and warrant further investigation for their potential role in host resistance/tolerance against N. ditissima.
Beyond overlap: considering habitat preference and fitness outcomes in the umbrella species concept
Authors: Carlisle J. D. , Smith K. T. , Beck J. L. , Murphy M. A. , Chalfoun A. D. 
Published: September 2023

AbstractUmbrella species and other surrogate species approaches to conservation provide an appealing framework to extend the reach of conservation efforts beyond single species. For the umbrella species concept to be effective, populations of multiple species of concern must persist in areas protected on behalf of the umbrella species. Most assessments of the concept, however, focus exclusively on geographic overlap among umbrella and background species, and not measures that affect population persistence (e.g. habitat quality or fitness). We quantified the congruence between the habitat preferences and nesting success of a high‐profile umbrella species (greater sage‐grouse,Centrocercus urophasianus, hereafter ‘sage‐grouse’), and three sympatric species of declining songbirds (Brewer's sparrowSpizella breweri, sage thrasherOreoscoptes montanusand vesper sparrowPooecetes gramineus) in central Wyoming, USA during 2012–2013. We used machine‐learning methods to create data‐driven predictions of sage‐grouse nest‐site selection and nest survival probabilities by modeling field‐collected sage‐grouse data relative to habitat attributes. We then used field‐collected songbird data to assess whether high‐quality sites for songbirds aligned with those of sage‐grouse. Nest sites selected by songbirds did not coincide with sage‐grouse nesting preferences, with the exception that Brewer's sparrows preferred similar nest sites to sage‐grouse in 2012. Moreover, the areas that produced higher rates of songbird nest survival were unrelated to those for sage‐grouse. Our findings suggest that management actions at local scales that prioritize sage‐grouse nesting habitat will not necessarily enhance the reproductive success of sagebrush‐associated songbirds. Measures implemented to conserve sage‐grouse and other purported umbrella species at broad spatial scales likely overlap the distribution of many species, however, broad‐scale overlap may not translate to fine‐scale conservation benefit beyond the umbrella species itself. The maintenance of microhabitat heterogeneity important for a diversity of species of concern will be critical for a more holistic application of the umbrella species concept.
Prevention of fetal brain injury in category II tracings
Authors: Nakao Masahiro , Ross Michael G. , Magawa Shoichi , Toyokawa Satoshi , Ichizuka Kiyotake , Kanayama Naohiro , Satoh Shoji , Tamiya Nanako , Nakai Akihito , Fujimori Keiya , Maeda Tsugio , Oka Akira , Suzuki Hideaki , Iwashita Mitsutoshi , Ikeda Tomoaki 
Published: September 2023

AbstractIntroductionWith category II fetal heart rate tracings, the preferred timing of interventions to prevent fetal hypoxic brain damage while limiting operative interventions remains unclear. We aimed to estimate fetal extracellular base deficit (BDecf) during labor with category II tracings to quantify the timing of potential interventions to prevent severe fetal metabolic acidemia.Material and methodsA longitudinal study was conducted using the database of the Recurrence Prevention Committee, Japan Obstetric Compensation System for Cerebral Palsy, including infants with severe cerebral palsy born at ≥34 weeks' gestation between 2009 and 2014. Cases included those presumed to have an intrapartum onset of hypoxic–ischemic insult based on the fetal heart rate pattern evolution from reassuring to an abnormal pattern during delivery, in association with category II tracings marked by recurrent decelerations and an umbilical arterial BDecf ≥ 12 mEq/L. BDecf changes during labor were estimated based on stages of labor and the frequency/severity of fetal heart rate decelerations using the algorithm of Ross and Gala. The times from the onset of recurrent decelerations to BDecf 8 and 12 mEq/L (Decels‐to‐BD8, Decels‐to‐BD12) and to delivery were determined. Cases were divided into two groups (rapid and slow progression) based upon the rate of progression of acidosis from onset of decelerations to BDecf 12 mEq/L, determined by a finite‐mixture model.ResultsThe median Decels‐to‐BD8 (28 vs. 144 min, p < 0.01) and Decels‐to‐BD12 (46 vs. 177 min, p < 0.01) times were significantly shorter in the rapid vs slow progression. In rapid progression cases, physicians' decisions to deliver the fetus occurred at ~BDecf 8 mEq/L, whereas the “decisions” did not occur until BDecf reached 12 mEq/L in slow progression cases.ConclusionsFetal BDecf reached 12 mEq/L within 1 h of recurrent fetal heart rate decelerations in the rapid progression group and within 3 h in the slow progression group. These findings suggest that cases with category II tracings marked by recurrent decelerations (i.e., slow progression) may benefit from operative intervention if persisting for longer than 2 h. In contrast, cases with sudden bradycardia (i.e., rapid progression) represent a challenge to prevent severe acidosis and hypoxic brain injury due to the limited time opportunity for emergent delivery.
Treatment patterns and visual acuity change of AMD patients, before, during and after the COVID‐19 pandemic lockdowns: A large cohort
Authors: Barequet Dana , Shor Reut , Segal Ori , Greenbaum Eran , Trivizki Omer , Loewenstein Anat , Rabina Gilad 
Published: September 2023

AbstractPurposeTo evaluate the impact of the changes in treatment patterns before, during and after the COVID‐19 pandemic on best‐corrected visual acuity (BCVA) in previously treated neovascular age‐related macular degeneration (nAMD) patients.MethodsA multi‐centre, retrospective, observational study of consecutive nAMD patients during 2019–2021. Data collected included demographics, BCVA, dates of intravitreal anti‐vascular endothelial growth factor (anti‐VEGF) injections and clinic visits.ResultsA total of 1652 eyes of 1652 nAMD patients were included, out of which 850 eyes were assessed in 2019 (pre‐COVID‐19), 630 eyes were assessed in 2020 (COVID‐19) and 974 eyes were assessed in 2021 (post‐COVID‐19). During the COVID‐19 period, the mean number of anti‐VEGF injections was significantly lower than the corresponding pre‐COVID‐19 and post‐COVID‐19 periods (5.55 compared to 6.13 and 6.60, respectively p < 0.01). A constant lower ratio of injections per patient/month was observed during COVID‐19 compared to previous and following years, with a notable decline during March–April, reaching a ratio of 0.4 in 2020 versus 0.65 in 2019 and 0.62 in 2021 (p < 0.01). Baseline BCVA (0.825, p < 0.001), number of injections (−0.007, p < 0.001), gender (−0.027, p = 0.037) and age (0.004, p < 0.001) were shown to be significant predictors of final BCVA.ConclusionDuring the COVID‐19 period, patients were treated with significantly less intravitreal anti‐VEGF injection compared to the previous year with compensation in the following year. These changes in treatment patterns did not have a significant impact on BCVA outcomes. Age, gender, baseline BCVA and number of injections are predictors of final visual outcomes.
Preparation of a new calcite layer from calcium glycolate for the conservation of sulfated limestone artifacts
Authors: Dong Taoling , Wang Lu , Li Ting , Yang Fuwei , Liu Yan , Zhang Kun 
Published: September 2023

AbstractA novel preparation method of calcite layer was explored for the conservation purpose of the surface sulfation limestone artifacts. In this method, the alcoholic solution of calcium glycolate was used as a precursor of calcite layer. After application on the surface of gypsum crust on limestone by spraying, calcium glycolate can combine with the carbon dioxide spontaneously and form a compact calcite layer. The obtained calcite layer can act as a shelter and can prevent the gypsum crust from the dissolution damage of the natural precipitation. The protective properties of the calcite layer were investigated by scanning electron microscopy with energy dispersive X‐ray spectroscopy (SEM/EDS), X‐ray diffraction (XRD), infrared spectroscopy (FTIR), water erosion resistance, water absorption, colour difference, surface strength, and hardness test. The results revealed that the water erosion resistance, surface strength, and hardness of the treated sample were increased remarkably. Meanwhile, the intrinsic physical properties such as porosity, capillary absorption, and appearance were not affected obviously, indicating a good compatibility of the proposed protection method.
The structurally diverse phytocannabinoids cannabichromene, cannabigerol and cannabinol significantly inhibit amyloid β‐evoked neurotoxicity and changes in cell morphology in PC12 cells
Authors: Marsh Dylan T. , Sugiyama Ayato , Imai Yuta , Kato Ryuji , Smid Scott D. 
Published: September 2023

AbstractBackgroundPhytocannabinoids (pCBs) have been shown to inhibit the aggregation and neurotoxicity of the neurotoxic Alzheimer's disease protein beta amyloid (Aβ). We characterized the capacity of six pCBs—cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), cannabidiol (CBD) and Δ9‐tetrahydrocannabinol (Δ9‐THC)—to disrupt Aβ aggregation and protect against Aβ‐evoked neurotoxicity in PC12 cells.MethodsNeuroprotection against lipid peroxidation and Aβ‐induced cytotoxicity was assessed using the MTT assay. Transmission electron microscopy was used to visualize pCB effects on Aβ aggregation and fluorescence microscopy, with morphometrics and principal component analysis to assess PC12 cell morphology.ResultsCBD inhibited lipid peroxidation with no significant effect on Aβ toxicity, whilst CBN, CBDV and CBG provided neuroprotection. CBC, CBG and CBN inhibited Aβ1–42‐induced neurotoxicity in PC12 cells, as did Δ9‐THC, CBD and CBDV. CBC, CBN and CBDV inhibited Aβ aggregation, whilst Δ9‐THC reduced aggregate density. Aβ1–42 induced morphological changes in PC12 cells, including a reduction in neuritic projections and rounded cell morphology. CBC and CBG inhibited this effect, whilst Δ9‐THC, CBD and CBDV did not alter Aβ1–42 effects on cell morphology.ConclusionsThese findings highlight the neuroprotective activity of CBC, CBG and CBN as novel pCBs associated with variable effects on Aβ‐evoked neurite damage and inhibition of amyloid β aggregation.
CD8+ T cell infiltration and proliferation in the brainstem during experimental cerebral malaria
Authors: Wang Jun , Zhu Qinghao , Shen Yan , Liang Jiao , Wang Yi , Huang Yuxiao , Tong Guodong , Wang Xu , Zhang Ningning , Yu Kangjie , Li Yinghui , Zhao Ya 
Published: September 2023

AbstractIntroductionCerebral malaria (CM) is a lethal neuroinflammatory disease caused by Plasmodium infection. Immune cells and brain parenchyma cells contribute to the pathogenesis of CM. However, a systematic examination of the changes that occur in the brain parenchyma region during CM at the single‐cell resolution is still poorly studied.AimsTo explore cell composition and CD8+ T cell infiltration, single‐cell RNA sequencing (scRNA‐seq) was performed on the brainstems of healthy and experimental cerebral malaria (ECM) mice. Then CD8+ T cell infiltration was confirmed by flow cytometry and immunofluorescence assays. Subsequently, the characteristics of the brain‐infiltrated CD8+ T cells were analyzed. Finally, the interactions between parenchyma cells and brain‐infiltrated CD8+ T cells were studied with an astrocytes‐CD8+ T cell cocultured model.ResultsThe brainstem is the most severely damaged site during ECM. ScRNA‐seq revealed a large number of CD8+ T cells infiltrating into the brainstem in ECM mice. Brain‐infiltrated CD8+ T cells were highly activated according to scRNA‐seq, immunofluorescence, and flow cytometry assays. Further analysis found a subset of ki‐67+ CD8+ T cells that have a higher transcriptional level of genes related to T cell function, activation, and proliferation, suggesting that they were exposed to specific antigens presented by brain parenchyma cells. Brain‐infiltrated CD8+ T cells were the only prominent source of IFN‐γ in this single‐cell analysis. Astrocytes, which have a high interferon response, act as cross‐presenting cells to recruit and re‐activate brain‐infiltrated CD8+ T cells. We also found that brain‐infiltrated CD8+ T cells were highly expressed immune checkpoint molecule PD‐1, while parenchyma cells showed up‐regulation of PD‐L1 after infection.ConclusionsThese findings reveal a novel interaction between brain‐infiltrated CD8+ T cells and parenchyma cells in the ECM brainstem, suggesting that the PD‐1/PD‐L1 signal pathway is a promising adjunctive therapeutic strategy for ECM targeting over‐activated CD8+ T cells.
The yield of cytology and histology obtained by endoscopic ultrasound‐guided fine needle aspiration and biopsy needles in the diagnosis of pancreatic adenocarcinoma
Authors: Sbeit Wisam , Abu Hanna Nidaa , Alejandro Livoff , Khoury Tawfik 
Published: September 2023

AbstractIntroductionEndoscopic ultrasound‐guided fine needle aspiration and biopsy (EUS‐FNA, ‐FNB) are the mainstay for tissue diagnosis of pancreatic lesions. Traditionally, FNA was performed for obtaining cytology and also histology if available from the puncture. Since their advent, however, FNB needles have been intended mainly to obtain core biopsies for histological specimens.AimsWe aimed to assess the yield of cytology obtained via both FNA and FNB needles.MethodsA retrospective study was performed including all patients who were diagnosed with pancreatic adenocarcinoma obtained via EUS‐FNA/FNB needles.ResultsOverall, 227 patients were included. Of them, 85 patients underwent FNB, versus 142 patients who had FNA. The average age in the FNB group was 70.46 ± 11.29 years, versus 71.44 ± 11.80 in the FNA group, P = 0.57. Notably, cytological analysis diagnosed malignancy equally in both groups (69.4% in the FNB group, vs. 65.5% in the FNA group). The compatibility rate of cytology with histology was 76.5% in the FNB group, versus 76.1% in the FNA group (P = 0.69). The agreement level between cytology obtained by FNA and FNB, versus histology obtained by both needles, was moderate (kappa = 0.48, 95% CI 0.39‐0.57). Similarly, the agreement level between cytology and histology in the FNB group was moderate as well (kappa = 0.5, 95% CI 0.36‐0.64).ConclusionCytological assessment yielded an equal performance as compared to histological assessment with both needles. We recommend obtaining cytology specimens in pancreatic solid lesion puncture by FNB needle.
“The compound mass we term SELF”: Mary Shepherd on selfhood and the difference between mind and self
Authors: Fasko Manuel 
Published: September 2023

AbstractIn this paper, I argue for a novel interpretation of Shepherd's notion of selfhood. In distinction to Deborah Boyle's interpretation, I contend that Shepherd differentiates between the mind and the self. The latter, for Shepherd, is an effect arising from causal interactions between mind and body—specifically those interactions that give rise to our present stream of consciousness, our memories, and that can unite these two. Thus, the body plays a constitutive role in the formation of the self. The upshot of this interpretation is that it can dissolve the problem of individuating mind that Boyle identifies. Briefly, the problem consists in Shepherd seemingly individuating minds in terms of their associated bodies and bodies in terms of the minds they are united with. My interpretation, however, allows to see that Shepherd neither wants nor needs to individuate the mind in isolation of the body and to read the passages, in which the problem seems to arise, as being about what makes living beings individual—with mind and body both playing a crucial role in this context.