bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Solar power plant sizing for high power demands using PSO algorithm and PVsyst: case study FITOULINA Tunisian group company
Authors: Arab Marwa Ben , Khamekhem Siwar , Rekik Mouna , Krichen Lotfi , Ayed Mohamed Ben , Amor Mohamed Ben 
Published: April 2023

Abstract
The importance of photovoltaic technology in Industry 4.0 cannot be overstated. As it is well-known, this technology harnesses the solar energy which is becoming a widely popular renewable energy source, and converts it into a clean electricity through the photovoltaic cells. This technology offers competitive benefits to the company, such as a saved cost, an enhanced process efficiency and then productivity, an increased energy independence, and a reduced carbon emission. In addition, the company gains a better decision making by the data analytics which provide a real-time insight and make more informed decisions. In this topic, the considered study deals with an optimal sizing of Solar Power Plant (SPP) for high power demands. Famously, the two important technologies of any SPP are the Photovoltaic Panels (PVPs) and the inverters. For that, an optimal sizing algorithm for the SPP using Particle Swarm Optimisation (PSO) algorithm and PVsyst is proposed. This optimal sizing is composed of two key parts: the first one aims to calculate the PVP different characteristics and consequently determines the number of PVPs and inverters that should be fixed in the SPP to satisfy the company demand. The second part deals with a mathematical optimized configuration based on three PSO algorithms. This optimized algorithm aims to seek the optimal SPP inverters and PVPs sizing to guarantee the company best energy efficiency by following four main cases. Fitoulina Tunisian group that required to cover 920.04kW of its power demand by photovoltaic technology, was presented as a case study to highlight the performance of this proposed algorithm. As a result, the algorithm reveals the necessity of installing 1394 PVPs connected to 8 inverters by following the fourth case of the proposed algorithm.
H2Valdien derivatives induce apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells via a p53-dependent pathway.
Authors: Li Hongling , Ma Weijie , Pan yang , Shao Xiangxiang , Pan Xuhong , Li Linyu , Zhou Xuan , Song pengfei 
Published: April 2023

Abstract
Objective: In this study, two human hepatocellular carcinoma cell lines, HepG2 (p53+/+) and Hep3B (p53-/-), were used with different p53 mutation statuses. The role of p53 in the induction of cytotoxicity by H2Valdien derivatives was investigated, as well as how p53 regulates GADD45a and p21. To examine whether the mechanism of action of H2Valdien derivatives on cell cycle arrest and apoptosis in human hepatocellular carcinoma cells is related to p53 deficiency.
Methods: Cell viability was analyzed using the CCK-8 assay, and RNA sequencing was used for differential gene expression and enrichment analyses. The expression of apoptosis and cell cycle related proteins was analyzed by western blotting. DAPI and TUNEL staining techniques were employed to effectively visualize the nuclear morphology and apoptotic properties of the cells under investigation. Cell proliferation ability was assessed using colony formation assays, and mitochondrial membrane potential (MMP) was detected by JC-1 staining. Cell cycle progression was assessed by flow cytometry.
Results: H2Valdien derivatives (5, 10, 20, and 40 mg/L) inhibited the proliferation of HepG2 and Hep3B cells and the formation of cell colonies in a dose-dependent manner, and decreased the MMP of HepG2 cells, but had no effect on the MMP of Hep3B cells. H2Valdien derivatives upregulated cleaved caspase-9, cleaved PARP, and Bax in HepG2 cells but not in Hep3B cells. RNA sequencing analysis revealed that H2Valdien derivatives increased p53, p21, and GADD45A expression, and western blotting and flow cytometry confirmed this finding. Despite the induction of p21 and GADD45a in Hep3B cells, there was no change in related proteins associated with drug concentration.
Conclusion: GADD45a and p21 expression is regulated by H2Valdien derivatives in a p53-dependent manner, and p53 has a pro-apoptotic impact on H2Valdien derivative-induced toxicity. H2Valdien derivative-induced apoptosis and cycle hinder are reduced by p53 deletion.
Macroscopic sarcocystosis in a pig carcass from an Italian abattoir
Authors: Rubiola Selene , Pasquariello Linda , Panebianco Felice , Capucchio Maria Teresa , Colombino Elena , Bordese Federica , Giobbio Enrique , Fioriello Lisa , Braghin Silvia , Korpysa-Dzirba Weronika , Różycki Mirosław , Chiesa Francesco 
Published: April 2023

Abstract
Different food-safety institutions, including the European Food Safety Authority, encourage monitoring and characterising Sarcocystis spp. in animals and foodstuffs; among meat-producing animals, domestic pigs (Sus scrofa) can host two different Sarcocystis spp., that is Sarcocystis miescheriana and Sarcocystis suihominis. Herein, we report for the first time the presence of macrocysts of Sarcocystis miescheriana in a domestic pig resulting in carcass condemnation. In June 2022, the carcass of a clinically healthy sow was condemned due to the detection of multifocal macroscopic white oval lesions. Affected muscle samples were submitted to histological and molecular analyses targeting the mtDNA cox1 and 18S rRNA genes. At gross examination and histology, well demarcated, oval or elongated macrocysts up to 8 mm in length characterized by a calcified central core surrounded by fibrosis were detected. The molecular amplification and sequencing of the cox1 mtDNA and 18S rRNA genes revealed the presence of Sarcocystis miescheriana DNA in all sampled macrocysts. Our study provides the first molecularly confirmed case of Sarcocystis miescheriana infection in a domestic pig in Italy. The present report highlights the need to increase data related to the occurrence and the prevalence of Sarcocystis spp. in meat-producing animals, and in wild and domestic pigs in particular, taking into account the zoonotic potential of Sarcocystis suihominis and the possible financial losses related to carcass discard due to macroscopic Sarcocystis spp. lesions.
Study the Influence of Zirconium Oxide Nanofillers on the Transverse and Impact Stresses of Heat-Cure Acrylic Resin Polymerization
Authors: Alfahdawi Ibrahim H. , Abdulateef Mohamed Abdulmunem 
Published: April 2023

Abstract
Objective: Despite being the more material widely using in dental field for the construction of removable prosthesis base, it is not sufficient for meet ideal functional requirement for dental restorations.
Purpose: The goal of this research was to see how various concentrations of zirconium oxide (ZrO2) nanofiller powder (2%, 4%, 6%, & 8%) affected the transverse and impact strengths of hot-cured polymer resin polymerization.
Procedure: ZrO2 powder samples of various doses (2%, 4%, 6%, & 8%) are embedded within hot-cured acrylic resin as well as handled under optimized conditions (L/P ratio of 1:3 (by volume), traditional packing process, and short curing cycle (90 minutes with 74 ºC then for 30 minutes with 100 ºC) was using to fabricate samples of PMMA of dimensions (65 x 10 x 2.5 mm) for the transverse strength and (60 x 7 x 4mm) for the impact strength. Polymethyl methacrylate with no additives has been prepared as an original approach. All specimens had been exposed to two types of mechanical examinations: transverse stress and impact stress. Transverse stress (MPa) in addition to impact stress (J) values are collect, tabulated, as well as statistical analyze. To evaluate significant among range for the experimental samples, each ANOVA as well as Tukey's examinations are being used, that are statistical significance whenever the probability values are 0.05.
Results: The adding of ZrO2 nanofillers for polymethyl methacrylate elevated its transverse and impact strengths significantly.
Conclusion: Polymethyl methacrylate and zirconium oxide nanofillers does have the possibility to serve as a credible denture base material with increased transverse and impact strengths. Material characteristics have been enhanced by incorporating 8% weight percent ZrO2 concentration, according to the report's findings.
Towards a Domain-specific Language for Developing Concurrent Applications using BIP Framework
Authors: Le-Khanh Trinh , Nguyen Son 
Published: April 2023

Abstract
Concurrent systems play a crucial role in modern software development, enabling applications to handle multiple tasks simultaneously and improve performance by utilizing the full potential of modern hardware. The Behavior-Interaction-Priority (BIP) framework is a model-driven approach for designing and verifying concurrent and distributed systems. To apply BIP in designing a system, designers first analyze the system's requirements to construct BIP connectors describing the coordination between the system's components. Based on these connectors, developers create a BIP model for verification that uses model checkers and JavaBIP artifacts for implementation following an exogenous approach. However, constructing the BIP connectors and creating BIP/JavaBIP artifacts require a certain level of expertise in formal methods, model-driven design, and concurrent systems. Consequently, the developers might need to invest time and effort to learn the framework and associated tools. In this work, we propose a novel mechanism to reduce developers' manual efforts when applying the BIP framework, including (1) a pseudo-natural language for specifying behavioral constraints without learning the BIP framework and (2) a compiler for automatically generating the BIP/JavaBIP artifacts, which are then used for developing concurrent software following the exogenous approach. We illustrate the feasibility of our approach by introducing OCCIwareBIP, a framework for designing, validating, and implementing concurrent cloud applications.
A comparison of the absolute and relative real analytic torsion forms
Authors: Zhu Jialin 
Published: April 2023

Abstract
In this paper we establish a comparison formula of the absolute and relative real analytic torsion forms over fibrations with boundaries. The key tool is a gluing formula of analytic torsion forms proved by M. Puchol, Y. Zhang and the author. As a consequence of the comparison formula, we prove another version of the gluing formula of the analytic torsion forms conjectured originally by the author.
The effect of coronary artery disease on the prognosis of hypertrophic cardiomyopathy: a multi-center cohort study
Authors: Liao Qian , Deng Xiaodan , Ma Huihui , Shu Yan , Zeng Shengzhi , zhou Yongmei , Luo Liangjun , Zhao Gang , He Tao , Liu Mingjiang , Tao Jianhong , Hua Wei , Li Xiaoping 
Published: April 2023

Abstract
Background: There is a paucity of patients with hypertrophic cardiomyopathy (HCM) developed coronary artery disease (CAD), and the impact of CAD on the prognosis of HCM patients is unknown. Therefore, our real-world cohort study aimed to investigate prognosis of CAD in patients with HCM.
Methods: A cohort study was undertaken in HCM patients from May 2003 to September 2021. A total of 2268 patients were enrolled, with a mean follow-up of 5.6 years (interquartile range 2.4-8.4 years). Outcome assessment was based on the all-cause mortality, cardiovascular mortality/cardiac transplantation and SCD.
Results: Among the 2268 patients studied, 353(15.6%) died during a mean follow-up of 5.6 years. The patients were divided into CAD (n=504) and non-CAD (n=1764) groups. No difference in the all-cause mortality, cardiovascular mortality/cardiac transplantation or SCD between patients with CAD and no CAD (log-rank c2=0.201, P=0.654; log-rank c2=0.233, P=0.629; log-rank c2=1.523, P=0.217). In the Cox analysis, CAD was not a significant independent predictor of all-cause mortality, cardiovascular mortality/cardiac transplantation or SCD in patients with HCM.
Conclusion: In conclusion, there was no significant differences in mortality between the HCM patients with and without CAD, indicating no effect of CAD on all-cause mortality, cardiovascular mortality/cardiac transplantation, and SCD in the present large-scale study.
Spatial and seasonal variability of autotrophic and heterotrophic picoplankton abundance and growth rates in the southern Bay of Biscay
Authors: Iglesia-Vélez Braulio de la , Díaz-Pérez Laura , Acuña José Luis , Morán Xosé Anxelu G. 
Published: April 2023

Abstract
Autotrophic and heterotrophic picoplankton play fundamental roles in marine food webs and biogeochemical cycles, but their growth responses have seldom been jointly assessed for many marine regions. We describe here the spatio-temporal variability of the abundances and specific growth rates of the picoplanktonic groups routinely distinguished by flow cytometry (Synechococcus and Prochlorococcus cyanobacteria, two groups of differently sized picoeukaryotes and two groups of heterotrophic bacteria distinguished by their relative nucleic acid content) in the central Cantabrian Sea (southern Bay of Biscay). To that end, from February to December 2021 we collected surface water on 5 occasions from 6 stations distributed along the northern Iberian coast (6 − 3°W) and incubated it after removing protistan grazers in order to determine their dynamics along the seasonal cycle as well as the inshore-offshore and the west-east gradients. Seasonal variations in initial and maximum abundances generally matched previous knowledge of the region but specific growth rates were more variable, with Prochlorococcus and high nucleic acid (HNA) bacteria showing the maximum values (up to 2 d− 1) while negative growth was observed in one third of Synechococcus incubations. Temporal differences generally overrode differences along the inshore-offshore gradient while in situ and maximum abundances of most of the groups generally decreased towards the east following the increase in stratification and lower nutrient availability. Responses to stratification suggest Prochlorococcus and low nucleic acid (LNA) cells may prevail among autotrophic and heterotrophic bacteria, respectively, in a warmer ocean.
Transformer Tracker based on Multi-level Residual Perception Structure
Authors: Chen Hui , Wang Zhenhai , Yuan Lutao , Ren Ying , Tian Hongyu 
Published: April 2023

Abstract
Recently, Transformer networks have been used for feature extraction and calculation of similarity in object tracking, replacing the previous use of CNN for feature extraction and cross-attention for feature fusion in Transformer based object tracking algorithms. This new structure is called one stream structure, and has achieved good results. However, the one stream structure of the Transformer tracker has too many network parameters, which limits the tracking speed of the network. For this reason, we have designed a pure one stream Transformer structure that uses soft segmentation operations to significantly reduce model parameters and computational complexity. In order to further improve the accuracy of tracking, we propose a multi-level residual perception structure to enhance the feature information of the target and reduce the background feature information, thereby enhancing the foreground and background discrimination ability of the model. In order to prove the speed and accuracy of our method, we not only compared it with algorithms using deep neural network models, but also compared it with UAV tracking algorithms using shallow networks. Compared with these algorithms, it can be proved that our algorithm not only has fast reasoning speed, but also has very high reasoning accuracy. Experimentally, the UAV123 dataset reached the level of SOTA; the inference speed can reach 130 FPS.
Oncological outcomes of surgical management for T2N0M0 glottic laryngeal squamous cell carcinoma
Authors: Zhou Jian , Zhu Xiaoke , Yang Yue , Zhou Liang , Gong Hongli , Xu Chengzhi , Tao Lei 
Published: April 2023

Abstract
Background: This research aimed to evaluate the clinical treatment outcomes of T2N0M0 glottic laryngeal squamous cell carcinoma (LSCC) patients who underwent laryngectomy.
Methods: Retrospectively review of 541 T2N0M0 glottic LSCC patients.
Results: 5-year cancer-specific survival (CSS) rate was 89.6%, and the overall survival (OS) rate was 88.5%. No statistically difference was found between the patients who have undergone total laryngectomy (5-year DFS = 80.7%, and the CSS = 86.7%) and those who have had partial laryngectomy (the 5-year DFS = 84.6%, and CSS = 90.5%). There was no difference in the CSS and DFS rates between patients with negative margins and those with positive margins following postoperative radiotherapy (PORT) ± chemotherapy (the CSS: 90.5% vs.79.9%, P = 0.335 and 5-year DFS: 84.2% vs. 77.8%, P = 0.289). Patients who underwent vertical partial laryngectomy (VPL) had better survival (5-year OS was 91.9%, and the CSS was 92.8%) than those who underwent cricohyoidoepiglottopexy (CHEP) or cricohyoidopexy (CHP) (the 5-year OS = 83.8%, P = 0.022 and CSS = 84.9%, P = 0.038).
Conclusion: Surgery remains the gold standard for treating T2N0M0 glottic LSCC patients because it can achieve satisfactory oncological outcomes. Regarding the systemic conditions, the effect of partial laryngectomy is similar to that of total laryngectomy. Moreover, partial laryngectomy preserves the function of the larynx. VPL may be superior to CHP/CHEP, depending upon the invasiveness of the tumor.
The Influence of Microcrystalline and Nanofibrillated Cellulose in XSBR Polymers on the Mechanical Properties of Jute Textile-Reinforced Cementitious Composites
Authors: Guimarães Túlio Caetano , Dias Matheus Cordazzo , de Araújo Olga Maria Oliveira , Lopes Ricardo Tadeu , Koenders Eddie , Filho Romildo Dias Toledo , Tonoli Gustavo Henrique Denzin , de Andrade Rodolfo Giacomim Mendes , Ferreira Saulo Rocha 
Published: April 2023

Abstract
This research aimed to improve the impregnation of XSBR (Carboxylate Styrene Butadiene Rubber) polymer on jute yarns, and hence the mechanical properties of a TRCC (Textile-Reinforced Cementitious Composite). Thus, an experimental investigation on the use of microcrystalline and nanofibrillated cellulose as additives to XSBR admixture was carried out. Four different solutions containing XSBR are presented, and each solution-fiber interaction and each treated fiber-matrix interaction were analysed. For those interaction analyses, the influence of XSBR impregnation was evaluated via SEM (Scanning Electron Microscopy) and TGA (Thermogravimetric Analysis), while the mechanical properties of the non-treated and treated jute fibers were evaluated via direct tensile test, and the bond between the treated and non-treated jute yarn and the cementitious matrix was evaluated via pull-out tests. Results showed a prominent enhancement not only to the mechanical behavior of the treated fibers, but to the TRCC's as well.
Mathematics Subject Classification (2020) MSC code1 · MSC code2 · more
Study lime-based mortars with added silica fume and bioproducts for restoration and preservation of heritage buildings
Authors: BARBOSA Maria Teresa , INNOCENCIO Camila Rezende , SALZANI Lucca Oliveira , PEREIRA Thales Silva , SOUZA Nelson Gonçalves Dias , OLIVEIRA Luiz Fernando Cappa 
Published: April 2023

Abstract
Restoration of heritage buildings requires an appropriate choice of materials, as inappropriate materials can lead to degradation rather than preservation. Hydrated lime and sand mortars are the most suitable for masonry cladding. However, they have low durability regarding current requirements. This work investigates the use of silica fume and/or biopolymers (egg albumen and additive derived from the reuse of milk unfit for human consumption (k-casein)) in the production of these mortars. Many mortars were characterized in terms of mechanical properties (compressive and diametric strength, absorption rate) and chemical properties (SEM, Infrared spectrum). The research revealed that the addition of silica fume allows an increase of more than 50% in the mechanical strength of the mortars and, when associated with animal protein, this value may be higher than 60%, especially for biopolymer (k-casein). Finally, the proteins in the preparation of mortars, which provides intense air entry, resulting in the formation of more pores. This increase in voids allows more CO2 to enter, which directly contributes to a faster carbonation process and performance mortar.
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis
Authors: Liu Yun , Cao Jia , Yang Qi , Zhu Linqi , Zhao Wenjun , Wang Xiuping , Yao Jun , Zhou Yong , Shao Shihe 
Published: April 2023

Abstract
Background Helicobacter pylori (H.pylori, HP) is one of the main causes of gastric cancer (GC). CircRNAs have been reported to play a crucial role in developing many types of cancer. However, the role of circRNAs in the development and progression of HP infected-GC has not been studied.Methods Nuclear and cytoplasmic RNA fractionation and RNA fluorescence in situ hybridization analysis (FISH) assays detected the location of circRNA_15430 in GC cells, and quantitative real-time polymerase chain reaction (qRT-PCR) analyzed circRNA_15430, miR-382-5p and ZCCHC14 expression in GC cell lines and tissues. Colony formation, cell counting kit-8 (CCK-8) and Transwell assays, flow cytometry and laser scanning confocal microscopy examined the function of circRNA_15430 in GC cells. Western blotting detected the protein levels. A dual-luciferase reporter assay monitored whether circRNA_15430 sponges miR-382-5p. Furthermore, circRNA_15430 was analyzed in vivo in tumor growth with nude mice.Results CircRNA_15430 is primarily localized in the cytoplasm of GC cells, and downregulated in the GC cell lines and tissues, and is negatively correlated with the tumor size. Downregulation of circRNA_15430 promotes proliferation, migration and suppresses cell apoptosis and autophagy in GC cells. Mechanically, circRNA_15430 acts as a miR-382-5p sponge, alleviating the inhibitory effect of miR-382-5p on its target ZCCHC14. Knockdown circRNA_15430 enhances tumor growth in vivo. In addition, circRNA_15430 was reduced in HP + gastritis tissues and HP-infected MGC-803 cells, reversing the pro-HP effect on autophagy. Additionally, miR-382-5p was increased in HP + gastritis tissue and HP-infected MGC-803 cells while ZCCHC14 decreased in HP-infected MGC-803 cells. MiR-382-5p reverses the effect of si-ZCCHC14 on autophagosome numbers in MGC-803 cells.Conclusions Therefore, circRNA_15430 plays an inhibitory role in GC and regulates the progression of HP infection-related GC, providing a novel molecular marker for GC therapy.