bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communication about diagnosis, prognosis, and prevention in the memory clinic: perspectives of European memory clinic professionals
Authors: Hendriksen Heleen M. A. , van Gils Aniek M. , van Harten Argonde C. , Hartmann Tobias , Mangialasche Francesca , Kamondi Anita , Kivipelto Miia , Rhodius-Meester Hanneke F. M. , Smets Ellen M. A. , van der Flier Wiesje M. , Visser Leonie N. C. 
Published: August 2023

Abstract
Background
The paradigm shift towards earlier Alzheimer’s disease (AD) stages and personalized medicine creates new challenges for clinician-patient communication. We conducted a survey among European memory clinic professionals to identify opinions on communication about (etiological) diagnosis, prognosis, and prevention, and inventory needs for augmenting communication skills.

Methods
Memory clinic professionals (N = 160) from 21 European countries completed our online survey (59% female, 14 ± 10 years' experience, 73% working in an academic hospital). We inventoried (1) opinions on communication about (etiological) diagnosis, prognosis, and prevention using 11 statements; (2) current communication practices in response to five hypothetical cases (AD dementia, mild cognitive impairment (MCI), subjective cognitive decline (SCD), with ( +) or without ( −) abnormal AD biomarkers); and (3) needs for communication support regarding ten listed communication skills.

Results
The majority of professionals agreed that communication on diagnosis, prognosis, and prevention should be personalized to the individual patient. In response to the hypothetical patient cases, disease stage influenced the inclination to communicate an etiological AD diagnosis: 97% would explicitly mention the presence of AD to the patient with AD dementia, 68% would do so in MCI + , and 29% in SCD + . Furthermore, 58% would explicitly rule out AD in case of MCI − when talking to patients, and 69% in case of SCD − . Almost all professionals (79–99%) indicated discussing prognosis and prevention with all patients, of which a substantial part (48–86%) would personalize their communication to patients’ diagnostic test results (39–68%) or patients’ anamnestic information (33–82%). The majority of clinicians (79%) would like to use online tools, training, or both to support them in communicating with patients. Topics for which professionals desired support most were: stimulating patients’ understanding of information, and communicating uncertainty, dementia risk, remotely/online, and with patients not (fluently) speaking the language of the country of residence.

Conclusions
In a survey of European memory clinic professionals, we found a strong positive attitude towards communication with patients about (etiological) diagnosis, prognosis, and prevention, and personalization of communication to characteristics and needs of individual patients. In addition, professionals expressed a need for supporting tools and skills training to further improve their communication with patients.
Long-term efficacy of anti-IL-4 receptor antibody in a patient with aspirin-exacerbated respiratory disease and IgG4-related disease
Authors: Jeon Hyun-Seob , Jang Jae-Hyuk , Lee Youngsoo , Park Hae-Sim 
Published: August 2023

Abstract
Background
Aspirin-exacerbated respiratory disease (AERD) and IgG4-related disease (IgG4RD) share a common pathway of Th2-mediated immune mechanism; there have been several cases of IgG4RD developed in patients with asthma, especially in those comorbid with chronic rhinosinusitis (CRS). IgG4RD has often been treated with systemic corticosteroids, rituximab, or immune-suppressive agents, but frequently failed with relapse.

Case presentation
Here, we present a case of a 64-year-old male patient with severe AERD with CRS complicated with IgG4RD, who has been successfully treated and maintained with anti-IL-4 receptor antibody, dupilumab after achieving unsatisfactory responses with previous treatments including steroids, rituximab, omalizumab, and reslizumab. The patient’s symptoms (periorbital swelling and asthmatic/nasal symptoms) were remarkably improved; serum levels of IgG4/IgE as well as plasmablast/eosinophil counts progressively decreased without any recurrence sign for over 2 years of dupilumab treatment.

Conclusion
These findings demonstrate that blocking the IL-4/IL-13 pathway with dupilumab can be an effective treatment with long-term safety in patients with severe AERD with CRS complicated by IgG4RD.
ROMSS: a rational optional multi-secret sharing scheme based on reputation mechanism
Authors: Shi Ruonan , Chen Yuling , Tan Chaoyue , Luo Yun , Li Tao 
Published: August 2023

AbstractThe traditional threshold secret sharing scheme only allows the participants’ sub-secret shares to be used once in the reconstruction process. Several multi-secret sharing schemes have been proposed that are related to cloud computing, aiming to improve reconstruction efficiency. Rational secret sharing is a technique that combines secret sharing with game theory. In traditional rational multi-secret sharing, participants must reconstruct all secrets, resulting in unnecessary overhead. Rational participants will act dishonestly to maximize their own interests, leading to a prisoner’s dilemma and incomplete secret reconstruction. Additionally, when sharing multiple secrets, the Dealer must distribute the sub-secret shares of all secrets to the participants, increasing overhead. In this paper, we propose a rational optional multi-secret sharing scheme based on a reputation mechanism that selectively reconstructs secrets according to participants’ needs in the context of cloud computing. Our scheme introduces a reputation mechanism to evaluate participants’ reputation values to avoid their dishonest behaviors. Furthermore, we adopt a broadcast encryption matrix so that participants only need to receive a single sub-secret share to participate in multi-secret reconstruction. Our security analysis shows that the proposed scheme can effectively constrain the self-interested behavior of rational participants and reduce the overhead in the process, thus multi-secret sharing scheme can provide more efficient and secure solutions for secret sharing in key management and distributive storage for the cloud scenarios.
The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study
Authors: Hajipour Azadeh , Ardekanizadeh Naeemeh Hassanpour , Roumi Zahra , Shekari Soheila , Aminnezhad Kavkani Bahareh , Shalmani Seyedeh Hayedeh Mousavi , Bahar Bojlul , Tajadod Shirin , Ajami Marjan , Tabesh Ghasem Azizi , Gholamalizadeh Maryam , Doaei Saeid 
Published: August 2023

Abstract
Background
Colorectal cancer (CRC) is one of the most common cancers in the world. Some dietary factors such as fat intake have been identified as the risk factors for CRC. This study aimed to investigate the effect of fat mass and obesity-associated (FTO) gene rs9939609 polymorphism on the association between CRC and different types of dietary fats.

Methods
This case-control study was performed on 135 CRC cases and 294 healthy controls in Tehran, Iran. Data on demographic factors, anthropometric measurements, physical activity, the intake of different types of dietary fats, and FTO gene rs9939609 polymorphism was collected from all participants. The association between cancer and dietary fat intake in individuals with different FTO genotypes was assessed using different models of logistic regression.

Results
Oleic acid intake was higher in the case group compared to the control group in both people with TT (7.2±3.46 vs. 5.83±3.06 g/d, P=0.02) and AA/AT genotypes (8.7±6.23 vs. 5.57 ±3.2 g/d, P<0.001). Among carriers of AA/AT genotypes of FTO rs9939609 polymorphism, a positive association was found between CRC and higher intakes of oleic acid (OR=1.12, CI95% 1.03–1.21, P=0.01) and cholesterol (OR=1.01, CI95% 1.00–1.02; P=0.01) after adjusting for age, sex, physical activity, alcohol use, smoking, calorie intake, and body mass index.

Conclusion
Higher intakes of cholesterol and oleic acid were associated with a higher risk of CRC in FTO-risk allele carriers. The association of CRC and dietary fat may be influenced by the FTO genotype. Further longitudinal studies are warranted to confirm these findings.
Salivary microbiome profiles of oral cancer patients analyzed before and after treatment
Authors: Mäkinen Anna I. , Pappalardo Vincent Y. , Buijs Mark J. , Brandt Bernd W. , Mäkitie Antti A. , Meurman Jukka H. , Zaura Egija 
Published: August 2023

Abstract
Background
Treating oral squamous cell carcinoma (OSCC) introduces new ecological environments in the oral cavity. This is expected to cause changes in the oral microbiome. The purpose of this study was to gain new information on the salivary microbiome of OSCC patients in order to improve the aftercare of OSCC patients. The aims of this study were to investigate possible changes in the salivary microbiome profiles of OSCC patients before and after cancer treatment and to compare these changes with the profiles of healthy controls.

Patients and methods
Paraffin-stimulated whole saliva samples were collected, and the salivary flow rate was measured from 99 OSCC patients prior to surgical resection of the tumor and other adjuvant therapy. After treatment, 28 OSCC patients were re-examined with a mean follow-up time of 48 months. In addition, 101 healthy controls were examined and sampled. After DNA extraction and purification, the V4 hypervariable region of the 16S rRNA gene was amplified and sequenced using Illumina MiSeq. The merged read pairs were denoised using UNOISE3, mapped to zero-radius operational taxonomic units (zOTUs), and the representative zOTU sequences were assigned a taxonomy using HOMD. Descriptive statistics were used to study the differences in the microbial profiles of OSCC patients before and after treatment and in comparison to healthy controls.

Results
At baseline, the OSCC patients showed a higher relative abundance of zOTUs classified as Streptococcus anginosus, Abiotrophia defectiva, and Fusobacterium nucleatum. The microbial profiles differed significantly between OSCC patients and healthy controls (F = 5.9, p < 0.001). Alpha diversity of the salivary microbiome of OSCC patients was decreased at the follow-up, and the microbial profiles differed significantly from the pre-treatment (p < 0.001) and from that of healthy controls (p < 0.001).

Conclusions
OSCC patients’ salivary microbiome profile had a higher abundance of potentially pathogenic bacteria compared to healthy controls. Treatment of the OSCC caused a significant decrease in alpha diversity and increase in variability of the salivary microbiome, which was still evident after several years of follow-up. OSCC patients may benefit from preventive measures, such as the use of pre- or probiotics, salivary substitutes, or dietary counseling.
Arula-7 powder improves diarrhea and intestinal epithelial tight junction function associated with its regulation of intestinal flora in calves infected with pathogenic Escherichia coli O1
Authors: Chen Hao , Jia Zhifeng , He Meiling , Chen Aorigele , Zhang Xin , Xu Jin , Wang Chunjie 
Published: August 2023

Abstract
Background
The effects of Arula-7 powder (ASP) on diarrhea and intestinal barrier function associated with its regulation of intestinal microflora in calves infected with pathogenic Escherichia coli O1 (E. coli O1) were studied.

Method
Twenty Holstein calves were randomly divided into four treatment groups: normal control (NC), model control (MC), 0.5 mg/kg ciprofloxacin (CIP) and 2.50 g/kg ASP groups.

Results
ASP inhibited the relative abundance of Proteobacteria, Selenomonadales, and Enterobacteriales, and increased the relative abundance of Lactobacillus, Faecalibacterium, and Alloprevotella. Moreover, we demonstrated for the first time that the ASP and CIP promoted weight gain, reduced the diarrhea rate (P < 0.05), and enhanced antioxidant capacity (P < 0.05) due to the increase in average daily gain (ADG), total protein (TP), and albumin (ALB). In addition, ASP and CIP increased the expression of Zunola occludens-1 (ZO-1), Occludin, and Claudin-1 in the ileum (P < 0.05), and improved immunity due to increase levels of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-γ (IFN-γ), immunoglobulin A (IgA), and immunoglobulin G (IgG) in the serum, strengthened CD4+T levels in the ileal mucosa and reducing CD8+T and CD11c+T (P < 0.05).

Conclusion
Hence, The intestinal microbiota environment formed by early intervention of ASP powder has a protective effect on the intestinal mucosal function of calves infected with pathogenic E. coli.
Geophysical characteristics of a fault system in the northern Central Range of Taiwan and its applications for geothermal energy exploration
Authors: Chen Bing-Cheng , Perdana Tito , Kuo Li-Wei 
Published: August 2023

AbstractThe northern Central Range of Taiwan is a high-potential geothermal region. Since the formations are mainly tight metasandstone and slate, permeable structures associated with faults are commonly considered as conduits of geothermal fluids. This study determines the characteristics and orientations of the permeable fault zones by analyzing the geophysical logs and microresistivity formation image log (FMI) of the JT-4 well in Jentse, an important geothermal area in the northern Central Range. Between 720 and 1480 m measured depth (MD), the effective porosity of the intact host rock is mostly below 3% calculated by the geophysical log. Zones with porosity greater than 5% are only clustered within a few thin intervals. The FMI interpretations show these porous zones are in the interior of the fractured and faulted intervals. These porous fault zones comprise fault damage zones with a high density of open fracture planes and fault cores with porous fault breccias. There is a highly brecciated fault core in 1334–1339 m MD, which would be the most permeable interval of the well. Additionally, some healed fault zones with sealed fractures are observed. The picked drilling-induced tensile fractures signify that the direction of the present-day maximum horizontal principal stress is N40–50°E, and most of the open fractures also strike parallel to the NE–SW direction. The study results show that the open fractures are concentrated in the four fault zones belonging to one major normal fault system. After integrating the orientations and locations of the fault zones, we propose that the permeable normal fault system is about 200 m wide, trends N50–70°E, and dips 70–80° to the NW. The development of the open fractures and the permeable fault system in the northern Central Range may be controlled by the current rifting of the Okinawa Trough offshore northeastern Taiwan. The study exhibits the characteristics of fractured fluid conduits of the regional geothermal system, which will benefit future geothermal exploration in northeastern Taiwan.
Time series data analysis under indeterminacy
Authors: Aslam Muhammad 
Published: August 2023

AbstractThe existing semi-average method under classical statistics is applied to measure the trend in the time series data. The existing semi-average method cannot be applied when the time series data is in intervals or imprecise. In this paper, we will introduce a semi-average method under neutrosophic statistics to measure the trend in imprecise or interval data. The application of the proposed semi-average method will be given using the wind speed data. The efficiency of the proposed semi-average method under neutrosophic statistics will be given over the semi-average method under classical statistics in terms of information and adequacy.
Limited or complete? Teaching and learning conceptions and instructional environments fostered by STEM teaching versus research faculty
Authors: Rozhenkova Veronika , Snow Lauren , Sato Brian K. , Lo Stanley M. , Buswell Natascha Trellinger 
Published: August 2023

Abstract
Background
An instructor’s conceptions of teaching and learning contribute to the establishment of learning environments that may benefit or hinder student learning. Previous studies have defined the continuum of teaching and learning conceptions, ranging from limited to complete, as well as the instructional practices that they help to inform (instructor-centered to student-centered), and the corresponding learning environments that these conceptions and practices establish, ranging from traditional to student-centered. Using the case of one STEM department at a research-intensive, minority serving institution, we explored faculty’s conceptions of teaching and learning and their resulting instructional practices, as well as uncovered their perspectives on the intradepartmental faculty interactions related to teaching. The study participants were drawn from both teaching-focused (called Professors of Teaching, PoTs) and traditional research (whom we call Research Professors, RPs) tenure-track faculty lines to identify whether differences existed amongst these two populations. We used interviews to explore faculty conceptions and analyzed syllabi to unveil how these conceptions shape instructional environments.

Results
Overall, PoTs exhibited complete conceptions of teaching and learning that emphasized student ownership of learning, whereas RPs possessed intermediate conceptions that focused more on transmitting knowledge and helping students prepare for subsequent courses. While both PoTs and RPs self-reported the use of active learning pedagogies, RPs were more likely to also highlight the importance of traditional lecture. The syllabi analysis revealed that PoTs enacted more student-centered practices in their classrooms compared to RPs. PoTs appeared to be more intentionally available to support students outside of class and encouraged student collaboration, while RPs focused more on the timeliness of assessments and enforcing more instructor-centered approaches in their courses. Finally, the data indicated that RPs recognized PoTs as individuals who were influential on their own teaching conceptions and practices.

Conclusions
Our findings suggest that departments should consider leveraging instructional experts who also possess a disciplinary background (PoTs) to improve their educational programs, both due to their student-centered impacts on the classroom environment and positive influence on their colleagues (RPs). This work also highlights the need for higher education institutions to offer appropriate professional development resources to enable faculty to reflect on their teaching and learning conceptions, aid in their pedagogical evolution, and guide the implementation of these conceptions into practice.
Distraction descriptor for brainprint authentication modelling using probability-based Incremental Fuzzy-Rough Nearest Neighbour
Authors: Liew Siaw-Hong , Choo Yun-Huoy , Low Yin Fen , Nor Rashid Fadilla ‘Atyka 
Published: August 2023

AbstractThis paper aims to design distraction descriptor, elicited through the object variation, to refine the granular knowledge incrementally, using the proposed probability-based incremental update strategy in Incremental Fuzzy-Rough Nearest Neighbour (IncFRNN) technique. Most of the brainprint authentication models were tested in well-controlled environments to minimize the influence of ambient disturbance on the EEG signals. These settings significantly contradict the real-world situations. Thus, making use of the distraction is wiser than eliminating it. The proposed probability-based incremental update strategy is benchmarked with the ground truth (actual class) incremental update strategy. Besides, the proposed technique is also benchmarked with First-In-First-Out (FIFO) incremental update strategy in K-Nearest Neighbour (KNN). The experimental results have shown equivalence discriminatory performance in both high distraction and quiet conditions. This has proven that the proposed distraction descriptor is able to utilize the unique EEG response towards ambient distraction to complement person authentication modelling in uncontrolled environment. The proposed probability-based IncFRNN technique has significantly outperformed the KNN technique for both with and without defining the window size threshold. Nevertheless, its performance is slightly worse than the actual class incremental update strategy since the ground truth represents the gold standard. In overall, this study demonstrated a more practical brainprint authentication model with the proposed distraction descriptor and the probability-based incremental update strategy. However, the EEG distraction descriptor may vary due to intersession variability. Future research may focus on the intersession variability to enhance the robustness of the brainprint authentication model.
Factors associated with 10-m walking speed in outpatients undergoing hemodialysis: a multicenter cross-sectional study
Authors: Yabe Hiroki , Nakano Haruka , Yamaguchi Tomoya , Takahashi Ren , Kono Kenichi , Moriyama Yoshifumi , Yamada Tetsuya 
Published: August 2023

Abstract
Introduction
Walking ability is an important prognostic factor for patients undergoing maintenance hemodialysis (HD). Since complications such as poor nutrition, anemia, malnutrition, and inflammation in patients undergoing HD may affect walking ability, the factors affected by 10-m walking speed must be investigated. This cross-sectional study enrolled 1205 outpatients undergoing HD and measured their 10-m walking speed.

Methods
Lower extremity muscle strength (LES), grip strength, one-leg standing time (OLST), and short physical performance battery (SPPB) score were measured as physical functions. Age, sex, body mass index, dialysis history, comorbidities, and hematological data were collected.

Results
A multiple regression analysis revealed that the 10-m walking speed was significantly associated with LES, grip strength, OLST, SPPB, and % creatinine production rate, even after adjusting for corresponding variables (R2 = 0.69, p < 0.05).

Conclusion
Muscle strength and muscle mass may be essential factors for the 10-m walking speed in patients undergoing HD.
Cannabis use for exercise recovery in trained individuals: a survey study
Authors: Pinzone Anthony G. , Erb Emily K. , Humm Stacie M. , Kearney Sarah G. , Kingsley J. Derek 
Published: August 2023

Abstract
Background
Cannabis use, be it either cannabidiol (CBD) use and/or delta-9-tetrahydrocannabinol (THC) use, shows promise to enhance exercise recovery. The present study aimed to determine if individuals are using CBD and/or THC as a means of recovery from aerobic and/or resistance exercise, as well as additional modalities that might be used to aid in recovery.

Methods
Following consent, 111 participants (Mean ± SD: Age: 31 ± 13 years) completed an anonymous survey. All participants were regularly using cannabis (CBD and/or THC) as well as were currently exercising. Questions pertained to level of cannabis use, methods used for consumption of cannabis, exercise habits, exercise recovery strategies, and demographics.

Results
Eighty-five percent of participants reported participating in aerobic training. In addition, 85% of participants also reported regular participation in resistance exercise. Seventy-two percent of participants participated in both aerobic and resistance exercise. Ninety-three percent of participants felt that CBD use assisted them with recovery from exercise, while 87% of participants felt the same regarding THC use.

Conclusions
Individuals who habitually use cannabis, CBD or THC, and regularly engage in exercise do feel that cannabis assists them with exercise recovery. More data are necessary to understand the role of cannabis in exercise recovery as well as perceived ergogenic benefits of cannabis by individuals who both regularly participate in exercise and habitually use cannabis.