bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alone, together: On the benefits of Bayesian borrowing in a meta‐analytic setting
Authors: Harari Ofir , Soltanifar Mohsen , Verhoek Andre , Heeg Bart 
Published: June 2023

AbstractIt is common practice to use hierarchical Bayesian model for the informing of a pediatric randomized controlled trial (RCT) by adult data, using a prespecified borrowing fraction parameter (BFP). This implicitly assumes that the BFP is intuitive and corresponds to the degree of similarity between the populations. Generalizing this model to any historical studies, naturally leads to empirical Bayes meta‐analysis. In this paper we calculate the Bayesian BFPs and study the factors that drive them. We prove that simultaneous mean squared error reduction relative to an uninformed model is always achievable through application of this model. Power and sample size calculations for a future RCT, designed to be informed by multiple external RCTs, are also provided. Potential applications include inference on treatment efficacy from independent trials involving either heterogeneous patient populations or different therapies from a common class.
Cumulative effects of dams on migratory fishes across the conterminous United States: Regional patterns in fish responses to river network fragmentation
Authors: Dean E. M. , Infante Dana M. , Yu Hao , Cooper Arthur , Wang Lizhu , Ross Jared 
Published: June 2023

AbstractGlobally, dams fragment river networks, threatening migratory fishes which require access to distinct habitats to complete their life cycles. Efforts to understand how cumulative effects of multiple dams affect migratory fishes across large regions, such as a country or continent, could help to identify locations for connectivity‐enhancing actions to conserve migratory fishes. To address this, we evaluated cumulative effects of dams on migratory fishes in rivers across nine ecoregions of the conterminous USA. First, using fish data from thousands of sites (N = 45,989), we summarized ecoregional patterns in assemblages, quantifying the number of migratory species comprising assemblages, showing the prominence of potamodromous species across the large region as well as differences in migratory life history traits among ecoregions. Next, we compared the importance of a set of river network fragmentation metrics that captured influences of multiple dams in networks versus other anthropogenic landscape stressors and natural landscape factors that impact migratory fishes by ecoregion. We found that migratory fishes were more sensitive to cumulative dam effects than other stressors including urbanization and agriculture in the eastern USA. To further identify specific effects of environmental variables on potamodromous fishes, we conducted Boosted Regression Trees analysis in the eastern ecoregions. Our results suggested that the key natural influences on river fishes included catchment area as well as river baseflow and air temperature, suggesting that migratory fishes may be affected by changing climate. Additionally, we found that downstream dams were more influential than other human stressors to potamodromous fishes, underscoring the importance of enhancing connectivity within river networks to conserve migratory fishes. Collectively, our results provide new insights in identifying threats to migratory fish species across the USA, providing information that can aid in conserving this vulnerable but ecologically and socioeconomically important group of fishes.
Is renewable energy a path towards sustainable development?
Authors: Liu Fangying , Su Chi Wei , Qin Meng , Umar Muhammad 
Published: June 2023

AbstractIn the process of global environmental governance, renewable energy (RE) has been the focus of government attention as an effective avenue to enhance environmental sustainability. Hence, this paper utilises the rolling‐window Granger causality test to probe the connection between RE and sustainable development (SD) and further probe whether RE can be a solution to reduce air pollution and boost ecological sustainability. The results reveal that RE has both positive and negative impacts on SD, which means that RE can effectively mitigate the ecological burden and progress toward SD in a certain period. This favourable impact supports the conclusions of the energy‐environment model, which indicates that the increasing share of RE is beneficial to improving environmental benefits. Conversely, the rise in SD drives more sustainable investment in clean energy projects and further contributes to RE generation growth. However, economic and government policy changes will affect sustainable investment in the renewable sector and transmit negative shocks to RE development. In the context of the increasingly severe environmental situation, the government should take some proactive measures favouring RE development and ecological sustainability to mitigate ecological deterioration and boost environmental quality.
Effects of Puerarin‐Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head
Authors: Zhao Yuxuan , Li Songhang , Feng Maogeng , Zhang Mei , Liu Zhiqiang , Yao Yangxue , Zhang Tianxu , Jiang Yueying , Lin Yunfeng , Cai Xiaoxiao 
Published: June 2023

AbstractOsteonecrosis of the femoral head (ONFH) is recognized as a common refractory orthopedic disease that causes severe pain and poor quality of life in patients. Puerarin (Pue), a natural isoflavone glycoside, can promote osteogenesis and inhibit apoptosis of bone mesenchymal stem cells (BMSCs), demonstrating its great potential in the treatment of osteonecrosis. However, its low aqueous solubility, fast degradation in vivo, and inadequate bioavailability, limit its clinical application and therapeutic efficacy. Tetrahedral framework nucleic acids (tFNAs) are promising novel DNA nanomaterials in drug delivery. In this study, tFNAs as Pue carriers is used and synthesized a tFNA/Pue complex (TPC) that exhibited better stability, biocompatibility, and tissue utilization than free Pue. A dexamethasone (DEX)‐treated BMSC model in vitro and a methylprednisolone (MPS)‐induced ONFH model in vivo is also established, to explore the regulatory effects of TPC on osteogenesis and apoptosis of BMSCs. This findings showed that TPC can restore osteogenesis dysfunction and attenuated BMSC apoptosis induced by high‐dose glucocorticoids (GCs) through the hedgehog and Akt/Bcl‐2 pathways, contributing to the prevention of GC‐induced ONFH in rats. Thus, TPC is a promising drug for the treatment of ONFH and other osteogenesis‐related diseases.
Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles
Authors: Hunter Morag Rose , Cui Lili , Porebski Benjamin Thomas , Pereira Sara , Sonzini Silvia , Odunze Uchechukwu , Iyer Preeti , Engkvist Ola , Lloyd Rebecca Louise , Peel Samantha , Sabirsh Alan , Ross‐Thriepland Douglas , Jones Arwyn Tomos , Desai Arpan Shailesh 
Published: June 2023

AbstractPoor understanding of intracellular delivery and targeting hinders development of nucleic acid‐based therapeutics transported by nanoparticles. Utilizing a siRNA‐targeting and small molecule profiling approach with advanced imaging and machine learning biological insights is generated into the mechanism of lipid nanoparticle (MC3‐LNP) delivery of mRNA. This workflow is termed Advanced Cellular and Endocytic profiling for Intracellular Delivery (ACE‐ID). A cell‐based imaging assay and perturbation of 178 targets relevant to intracellular trafficking is used to identify corresponding effects on functional mRNA delivery. Targets improving delivery are analyzed by extracting data‐rich phenotypic fingerprints from images using advanced image analysis algorithms. Machine learning is used to determine key features correlating with enhanced delivery, identifying fluid‐phase endocytosis as a productive cellular entry route. With this new knowledge, MC3‐LNP is re‐engineered to target macropinocytosis, and this significantly improves mRNA delivery in vitro and in vivo. The ACE‐ID approach can be broadly applicable for optimizing nanomedicine‐based intracellular delivery systems and has the potential to accelerate the development of delivery systems for nucleic acid‐based therapeutics.
Effectiveness and implementation challenges of a livestock asset transfer intervention for smallholders in community‐protected areas in Cambodia
Authors: Huy Sokchea , Pheng Buntha , Khieu Borin , Chhay Ty , Philp Joshua N. M. , Hidano Arata 
Published: June 2023

AbstractBackgroundLimited opportunities to generate income in community‐protected areas (CPAs) often lead to the illegal harvesting of wildlife and natural resources, undermining the aim of protected areas. Sustained livestock production can be an alternative income source.ObjectivesTo understand the effectiveness and feasibility of livestock production in CPAs.MethodsWe conducted a livestock asset transfer intervention in 25 CPAs across three agroecological zones in Cambodia. We monitored livestock mortality, consumption and sales of livestock over 2 years. Participant observations and structured questionnaires were conducted to elicit information about constraints for livestock production perceived by the participants. A total of 756 households were recruited and 320, 184 and 252 households received chicken, pigs and cattle, respectively. All participants received technical training in livestock production and biosecurity management practices.ResultsAfter the intervention, the number of chickens, pigs and cattle increased on average by 5.9 (range: 0.3–26.3), 0.5 (−1 to 2.7) and 0.12 (0–0.35) per 1 input animal, respectively. The extent of increase was significantly different between zones only for chickens (Kruskal–Wallis test p = 0.004). The number of chickens and pigs sold per household was significantly different among zones. We observed that training was ineffective to alter livestock management practices in some CPAs, which partially explains their suboptimal performance of livestock production.ConclusionsUnderstanding contextual factors required for successful livestock production in CPAs is crucial for improving livelihoods and preventing biodiversity loss in Cambodia.
Introduction: The Re-Presentation of Research in Popularization Discourse
Authors: Sterk Florentine Marnel , van Goch Merel M. 
Published: June 2023

AbstractIn this chapter, we introduce our book,Re-presenting Research. In this book, the focus is firmly on textual popularization discourse as a form of communication to re-present academic insights to a larger, non-expert audience in an understandable and engaging manner. Our own research into science journalism writing skills in undergraduate university students serves as a starting point for the exploration of popularization discourse as a genre. The book gives an exposition of current theories, employed methodologies, and existing frameworks and rubrics that cover popularization discourse. We focus on the conceptual and textual features of popularization discourse, which are called ‘strategies’ in this book. In this introduction, we establish the need for this book and introduce what it is about, the topics it will cover, and the example analyses that are provided.
Revisiting Vh(→ $$ b\overline{b} $$) at the LHC and FCC-hh
Authors: Bishara Fady , Englert Philipp , Grojean Christophe , Panico Giuliano , Rossia Alejo N. 
Published: June 2023

Abstract
Diboson production processes provide good targets for precision measurements at present and future hadron colliders. We consider Vh production, focusing on the h → $$ b\overline{b} $$
b

b
¯

decay channel, whose sizeable cross section makes it accessible at the LHC. We perform an improved analysis by combining the 0-, 1- and 2-lepton channels with a scale-invariant b-tagging algorithm that allows us to exploit events with either a boosted Higgs via mass-drop tagging or resolved b-jets. This strategy gives sensitivity to 4 dimension-6 SMEFT operators that modify the W and Z couplings to quarks and is competitive with the bounds obtained from global fits. The benefit of the h → $$ b\overline{b} $$
b

b
¯

decay channel is the fact that it is the only Vh channel accessible at the LHC Run 3 and HL-LHC, while at FCC-hh it is competitive with the effectively background-free h → γγ channel assuming ≲ 5% systematic uncertainty. Combining the boosted and resolved categories yields a 17% improvement on the most strongly bounded Wilson coefficient at the LHC Run 3 with respect to the boosted category alone (and a 7% improvement at FCC-hh). We also show that, at FCC-hh, a binning in the rapidity of the Vh system can significantly reduce correlations between some EFT operators. The bounds we obtain translate to a lower bound on the new physics scale of 5, 8, and 20 TeV at the LHC Run 3, HL-LHC, and FCC-hh respectively, assuming new-physics couplings of order unity. Finally, we assess the impact of the Vh production channel on anomalous triple gauge coupling measurements, comparing with their determination at lepton colliders.
Mental Health im Kindesalter: der Einfluss von Mediennutzung, Erziehungsverhalten und elterlichem Stresserleben – eine Sekundärdatenanalyse von KiGGS- und BELLA-Daten
Authors: Jörren Hannah Lea , Schmidt Hannah , Kaman Anne , Ravens-Sieberer Ulrike , Rumpf Hans-Jürgen , Pawils Silke 
Published: June 2023

Zusammenfassung
Hintergrund
Studien zeigen einen Zusammenhang zwischen hoher Mediennutzung und psychischen Auffälligkeiten im Kindesalter. Unklar ist jedoch die Rolle von möglichen weiteren Faktoren, die diesen Zusammenhang beeinflussen. Das Ziel der Studie war die Prüfung von Zusammenhängen zwischen psychischen Auffälligkeiten, hoher Mediennutzung, elterlichem Stresserleben sowie inkonsistentem und positivem Erziehungsverhalten.

Methoden
Auf Basis des KiGGS- und BELLA-Datensatzes wurde der Zusammenhang zwischen psychischen Auffälligkeiten und einer hohen Mediennutzung bei Vorschulkindern (Alter: 3–5 Jahre, n = 417) und Schulkindern (Alter: 7–13 Jahre, n = 239) mittels logistischer Regressionen quer- und längsschnittlich untersucht. Kontrollvariablen waren sozioökonomischer Status, Geschlecht des Kindes und der Eltern, elterliches Stresserleben sowie inkonsistentes und positives Erziehungsverhalten.

Ergebnisse
Im Querschnitt zeigten sich bei Vorschulkindern Zusammenhänge zwischen psychischen Auffälligkeiten mit einer hohen Mediennutzung (OR = 3,02; p = 0,003), elterlichem Stresserleben (OR = 17,00; p < 0,001) und positivem Erziehungsverhalten (OR = 0,24; p < 0,001). Im Längsschnitt zeigte sich bei Schulkindern ein Zusammenhang zwischen psychischen Auffälligkeiten mit elterlichem Stresserleben (OR = 4,04; p < 0,001). Sozioökonomischer Status, Geschlecht des Kindes und Geschlecht der Eltern standen nicht im Zusammenhang mit psychischen Auffälligkeiten.

Diskussion
Neben den Wirkmechanismen der digitalen Medien scheinen elterliche Variablen entscheidend für die psychische Gesundheit im Kindesalter zu sein. Sie sollten bei einer ganzheitlichen Betrachtung kindlicher psychischer Gesundheit im Sinne einer Stärkung der elterlichen Kompetenzen Berücksichtigung finden.
Offshore construction using gravity-base foundations indicates no long-term impacts on dolphins and harbour porpoise
Authors: Potlock Kelsey M. , Temple Andrew J. , Berggren Per 
Published: June 2023

Abstract
There are concerns about the short- and long-term effects on cetaceans from offshore construction using pile-driving. Gravity-base foundations and anchored floating turbines are alternative installation methods that may have less impact on cetaceans. In this study, we investigated the response of dolphins (Tursiops truncatus and Lagenorhynchus albirostris) and harbour porpoise (Phocoena phocoena) to the construction of wind turbines using gravity-base foundations off Blyth, Northumberland, United Kingdom using cetacean echolocation recorders (C-PODs). Data were collected at nine sites across 3 years (2016–2018) before, during and after construction. Generalised additive mixed models were used to investigate temporal, environmental, and anthropogenic drivers of dolphin and porpoise occurrence from 143,215 h (5967 days) of C-POD data. The models explained 27% and 30% of the deviance in dolphin and porpoise occurrence, respectively. Overall, the results showed no long-term effect on the dolphin occurrence from the construction of the gravity-base wind turbine array. In contrast, porpoise occurrence increased by 32% and 75%, respectively, in the years during and after construction, compared to the before-construction year. Other predictors of dolphin and porpoise occurrence included month, hour of day, tidal currents and vessel sonar activity. Our findings indicate that wind turbine installation using gravity-base foundations had no long-term effects on the occurrence of dolphins or porpoise and may represent an offshore construction methodology that is less impactful to dolphins and harbour porpoise than impact pile-driven turbine installation methods. These results are important for future offshore energy developments; however, further studies are recommended to investigate potential species and location variations.
“It is becoming increasingly difficult to find reviewers”—myths and facts about peer review
Authors: Zupanc Günther K. H. 
Published: June 2023

AbstractA frequent complaint of editors of scientific journals is that it has become increasingly difficult to find reviewers for evaluating submitted manuscripts. Such claims are, most commonly, based on anecdotal evidence. To gain more insight grounded on empirical evidence, editorial data of manuscripts submitted for publication to the Journal of Comparative Physiology A between 2014 and 2021 were analyzed. No evidence was found that more invitations were necessary over time to get manuscripts reviewed; that the reviewer’s response time after invitation increased; that the number of reviewers who completed their reports, relative to the number of reviewers who had agreed to review a manuscript, decreased; and that the recommendation behavior of reviewers changed. The only significant trend observed was among reviewers who completed their reports later than agreed. The average number of days that these reviewers submitted their evaluations roughly doubled over the period analyzed. By contrast, neither the proportion of late vs. early reviews, nor the time for completing the reviews among the punctual reviewers, changed. Comparison with editorial data from other journals suggests that journals that serve a smaller community of readers and authors, and whose editors themselves contact potential reviewers, perform better in terms of reviewer recruitment and performance than journals that receive large numbers of submissions and use editorial assistants for sending invitations to potential reviewers.
Time-dependent changes in P2Y12 reaction unit values for predicting the different types of cardiovascular events in patients with ischemic heart disease
Authors: Aizawa Takatoku , Inoue Yasunori , Ito Satoshi , Morimoto Satoshi , Ogawa Kazuo , Nagoshi Tomohisa , Minai Kosuke , Ogawa Takayuki , Kawai Makoto , Yoshimura Michihiro 
Published: June 2023

AbstractSeveral studies have investigated the association between P2Y12 reaction unit (PRU) value and major adverse cardiovascular events (MACEs) in patients with ischemic heart disease, but there is no well-established consensus on the utility of PRU value. Furthermore, the optimal PRU cut-off value varied with studies. One reason may be that the endpoints and observation periods differed, depending on the study. This study aimed to investigate the optimal cut-off and predictive ability of the PRU value for predicting cardiovascular events, while considering different endpoints and observation periods. We surveyed a total of 338 patients receiving P2Y12 inhibitors and measured PRU during cardiac catheterization. Using time-dependent receiver operating characteristic analysis, we evaluated the cut-off and area under curve (AUC) of the PRU value for two MACEs (MACE ①: composite of death, myocardial infarction, stent thrombosis, and cerebral infarction; MACE ②: composite of MACE ① and target vessel revascularization) at 6, 12, 24 and 36 months after cardiac catheterization. MACE ① occurred in 18 cases and MACE ② in 32 cases. The PRU cut-off values at 6, 12, 24, and 36 months were 257, 238, 217, and 216, respectively, for MACE ① and 250, 238, 209, and 204, respectively, for MACE ②. The AUCs at 6, 12, 24, and 36 months were 0.753, 0.832, 0.718, and 0.717, respectively, for MACE ① and 0.724, 0.722, 0.664, and 0.682, respectively, for MACE ②. The optimal cut-off and predictive ability of PRU values for cardiovascular events varied depending on different endpoints and duration of the observation periods. A relatively high PRU value is effective for short-term event suppression, but a low value is required for long-term event suppression.
Omega-3 polyunsaturated fatty acids improve intestinal barrier integrity—albeit to a lesser degree than short-chain fatty acids: an exploratory analysis of the randomized controlled LIBRE trial
Authors: Seethaler Benjamin , Lehnert Katja , Yahiaoui-Doktor Maryam , Basrai Maryam , Vetter Walter , Kiechle Marion , Bischoff Stephan C. 
Published: June 2023

Abstract

Purpose
Adherence to the Mediterranean diet is associated with beneficial health effects, including gastrointestinal disorders. Preclinical studies suggest that omega-3 polyunsaturated fatty acids (n-3 PUFAs), found in Mediterranean foods like nuts and fish, improve intestinal barrier integrity. Here, we assessed possible effects of n-3 PUFAs on barrier integrity in a randomized controlled trial.

Methods
We studied 68 women from the open-label LIBRE trial (clinicaltrials.gov: NCT02087592) who followed either a Mediterranean diet (intervention group, IG) or a standard diet (control group, CG). Study visits comprised baseline, month 3, and month 12. Barrier integrity was assessed by plasma lipopolysaccharide binding protein (LBP) and fecal zonulin; fatty acids by gas chromatography with mass spectrometry. Median and interquartile ranges are shown.

Results
Adherence to the Mediterranean diet increased the proportion of the n-3 docosahexaenoic acid (DHA) (IG + 1.5% [0.9;2.5, p < 0.001]/ + 0.3% [− 0.1;0.9, p < 0.050] after 3/12 months; CG + 0.9% [0.5;1.6, p < 0.001]/ ± 0%) and decreased plasma LBP (IG − 0.3 µg/ml [− 0.6;0.1, p < 0.010]/ − 0.3 µg/ml [− 1.1; − 0.1, p < 0.001]; CG − 0.2 µg/ml [− 0.8; − 0.1, p < 0.001]/ ± 0 µg/ml) and fecal zonulin levels (IG − 76 ng/mg [− 164; − 12, p < 0.010]/ − 74 ng/mg [− 197;15, p < 0.001]; CG − 59 ng/mg [− 186;15, p < 0.050]/ + 10 ng/mg [− 117;24, p > 0.050]). Plasma DHA and LBP (R2: 0.14–0.42; all p < 0.070), as well as plasma DHA and fecal zonulin (R2: 0.18–0.48; all p < 0.050) were found to be inversely associated in bi- and multivariate analyses. Further multivariate analyses showed that the effect of DHA on barrier integrity was less pronounced than the effect of fecal short-chain fatty acids on barrier integrity.

Conclusions
Our data show that n-3 PUFAs can improve intestinal barrier integrity.
Trial registration number: The trial was registered prospectively at ClinicalTrials.gov (reference: NCT02087592).