bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Attempt to Determine the Magnitudes and Epicenters of Significant Historical Earthquakes in the Pannonian Basin
Authors: Varga Peter , Győri Erzsébet , Fodor Csilla , Timár Gábor 
Published: March 2023

AbstractThis study aims to determine the epicenters and magnitudes of pre-instrumental historical earthquakes in the Pannonian basin based on contemporary sources and the literature that recorded the effects, damage, and accompanying events. A local intensity value for a given place was estimated only if it could be determined based on contemporary data. Using intensity data from different locations, the position of the hypocenter and magnitude of the historic earthquakes were calculated using an empirical equation. The epicenter positions were compared with the spatial distribution of liquefaction phenomena, foreshocks, and aftershocks, for which data were available. Finally, the set of historical Mw≥5.5 events is supplemented with locations of instrumentally measured earthquakes of similar sizes, and the relationship between the location of the resulting seismic events and the main tectonic structures of the Pannonian basin is investigated. Our investigation suggests that the location of the earthquake epicenters is not linked to known major tectonic structures and that the earthquake activity in the Pannonian basin may be higher than previously thought.
Successful Bullying Prevention: a Curriculum Based on Cooperative Learning – Theoretical Analysis
Authors: Diac Georgeta , Grădinariu Tudorița 
Published: March 2023

At the level of pre-university education units in Romania, there is a visible concern for identifying the most effective strategies to prevent bullying in parallel with the development of social skills for positive interaction. In accordance with these trends, this work aims to identify some educational strategies to prevent bullying that value the dynamics of cooperation. Thus, in the present study we propose to present the theory of social interdependence from the perspective of cooperative learning in the prevention of bullying. In the scientific literature it is shown that students who have more experiences of cooperation have an increased probability of not developing individualistic tendencies or engaging in intentional acts of aggression. On the other hand, social dominance theories show that through competition students compete for a place in dominance hierarchies and may have harmful intentions.
The findings of various researchers show that cooperation is an effective strategy against bullying both in secondary school and in primary school. Cooperative learning significantly reduces bullying because bullies and victims share a tendency to be uncooperative. It was also observed that the results of cooperative learning on prosocial ability they have related by the improvement of the relationship between students. Given that bullies prefer to dominate rather than be cooperative, while victims lack social interaction skills, we believe that the success of bullying prevention is found in a curriculum centered on cooperative learning. Therefore, the design of such a curriculum is important from the perspective of developing students' cooperation and interrelationship skills as a strategy to prevent bullying.
Ultra-Processed Food can be a Mediator between Food Security Status and Overweight or Obesity among Adults: A Literature Review
Authors: Faza Farah , Bafani Unun Fitry Febria , Fikha Idri Iqra 
Published: March 2023

Background: The ultra-processed food (UPF) contributed 20-85% of total daily calories. The consumption of UPF can be triggered by food security status. Many studies revealed that UPF consumption has a direct negative impact on health, mainly in overweight and obesity.
Objectives: To review published studies assessing food security, UPF consumption, and overweight or obesity and find the possible links between those three factors.
Methods: A literature review of scientific articles about food security, UPF consumption, and overweight or obesity, selected systematically according to the PRISMA Diagram. All articles were gathered through medical search engines, including PubMed, ScienceDirect, and Scopus, from December 2021 to February 2022. The bias risk of each selected paper was assessed using the checklist from The Joanna Briggs Institute (JBI) Critical Appraisal. Peer review and group discussions were performed to assess the quality of all articles gathered as objectively as possible using the STROBE Checklist. A narrative synthesis approach was opted to unify all findings across included studies systematically.
Results: Nineteen (19) scientific published papers were filtered. The association between food security status and UPF consumption showed inconsistent findings. However, UPF consumption revealed a consistent association with overweight/obesity, where the higher the UPF intake, the greater odds of being overweight/obese. The relationship between food security status and overweight or obesity tended to have a similar pattern. In high-income countries, the association was negative (the more food insecure, the higher overweight or obesity), while in low- and middle-income countries showed the opposite. The pathway could be: (1) food-insecure adults have higher UPF intake, hence gaining body weight, or (2) food-secure adults have higher UPF intake, hence gaining body weight.
Conclusions: UPF consumption is indicated as a potential mediator for food security status and nutritional status (overweight/obesity) through two pathways involving socio-demographic factors, psychological factors, social protections, and food choice motives.
Total Flavonoid dan Aktivitas Antioksidan Food Bar Torbangun – Katuk terhadap Efektivitas Produksi ASI
Authors: Lutfiani Laeli , Nasrulloh Nanang 
Published: March 2023

Latar Belakang: Sebab utama terputusnya ASI eksklusif adalah produksi susu yang tidak lancar. Torbangun dan Katuk merupakan galactagogue yang dapat menstimulasi produksi ASI. Modifikasi pengolahan food bar menggunakan Torbangun dan Katuk merupakan bentuk fortifikasi pangan untuk meningkatkan produksi ASI Ibu menyusui.
Tujuan: Mengidentifikasi total flavonoid dan aktivitas antioksidan tepung Torbangun, tepung Katuk dan produk food bar Torbangun Katuk serta menganalisis efektivitas food bar Torbangun Katuk terhadap produksi ASI.
Metode: Pre-eksperimen menggunakan rancangan pre test and post test design untuk melihat produksi ASI sebelum dan sesudah mengonsumsi food bar. Bahan baku dan produk food bar dianalisis total flavonoid dengan aluminium klorida (AlCl3) dan aktivitas antioksidan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil). Food bar adalah produk dengan penambahan tepung Torbangun 2,5% dan tepung Katuk 5%. Uji efektivitas dilakukan pada 10 Ibu menyusui. Efektivitas dilihat dari perubahan volume ASI sebelum dan setelah mengonsumsi food bar. Pengaruh food bar terhadap produksi ASI menggunakan uji T berpasangan.
Hasil: Analisis kimia yang didapatkan total flavonoid tepung Torbangun dan Katuk adalah 4,06 mg/g dan 5,30 mg/g serta antioksidan tepung Torbangun dan Katuk 39,77 ppm dan 307,96 ppm. Sementara itu, total flavonoid dan aktivitas antioksidan produk food bar Torbangun Katuk berturut-turut 0,36±0,06 mg/g dan 116,01±36,83 ppm. Hasil efektivitas menunjukkan terdapat kenaikan 54,98% antara rata-rata volume ASI sebelum dan setelah konsumsi food bar. Pemberian food bar berpengaruh signifikan terhadap kenaikan produksi ASI (p<0,05).
Kesimpulan: Tepung Torbangun dan tepung Katuk memiliki potensi sebagai makanan tambahan untuk meningkatkan produksi ASI
Content-Based Image Retrieval using Multi Deep Neural Networks and K-Nearest Neighbor Approaches
Authors: Hung Bui Thanh , Pramanik Sabyasachi 
Published: March 2023

Abstract
With the rapid development of digital image technology, the number of digital images stored on the Internet environment has been increasing remarkably over the past decade. As a result, it has become a top priority to come up with an effective and convenient search tools for images. Although several image-based search tools have been introduced till now to allow users to search for images with relatively fast response times, it remains certain limitations from these tools in resolving ambiguity between content of the query image and returned image. In this research, we proposed a method exploiting multi deep neural networks and K-Nearest Neighbor methodologies in Content Based Image Retrieval to improve the image search quality. First, we built our own multi CNN models inherited from the pre-trained CNN models to extract image features. Next, basing on the method of K-Nearest Neighbors, we compiled the similarity measure of the distance between the feature vectors and conducted model experiments. Experiments were performed on the Oxford-IIIT Pet Image Dataset and self-collected dataset of a Kaggle competition. We then evaluated the model by accuracy, confusion matrix, and F1 scores; average precision (AP) and mean average precision (mAP) were used to evaluate the search results of our search proposed system. The experiments show that our proposed system achieved outstanding results.
The characteristics of cardiac rehabilitation interventions provided by nurses: A scoping review
Authors: Bernier Jessica , Breton Mylaine , Poitras Marie-eve 
Published: March 2023

Abstract

Background:A cardiac rehabilitation program (CRP) is an interdisciplinary intervention that combines the medical, social, and educational components necessary for cardiac rehabilitation so that people with cardiovascular disease can regain their functional abilities and improve their quality of life. In CRP, nurses have an essential role in patient care and service coordination. The basic components of a CRP that can be adapted remain unknown, as there are many different CRP. This study aims to identify the key features of a CRP that can inform public policy. Currently, there is no synthesis of the characteristics of services in CRP that can be adapted in the literature. This study aims to identify the main characteristics of cardiac rehabilitation programs nurses offer when providing cardiac rehabilitation after a myocardial infarction.Methods:A scoping study was conducted according to Arksey and O'Malley (2005). We systematically searched CINAHL, MEDLINE, Scopus, and Cochrane. Only empirical studies published between 2005 and 2022 with a CRP involving a nurse were included. CRP characteristics were classified, coded, and validated with the research team and categorized for analysis.Results:Fifteen articles were included in which 15 rehabilitation programs were identified. In total, four programs were offered, individualized nurse follow-up (n = 8), CRP solicitation (n = 2), use of technology (n = 3), and telehealth (n = 1). Overall, the features were categorized into four program types: 1) Interventions promoting early recruitment of participants; 2) Interventions promoting technology use; 3) Interventions based on multiple components; and 4) Interventions based on surveillance and monitoring activities.Conclusion:With the increase in myocardial infarctions, more and more patients need CRP. Nurse monitoring during CRP can be offered with several components to facilitate follow-up. These different follow-up components allow the nurse to anticipate care issues and obstacles the patient may encounter throughout cardiac rehabilitation. These elements should be promoted for engagement and participation in CR to improve CR provision. Finally, the characteristics of this study will support the conceptualization of a CR program.
Validation of TBL-PBL Teaching Model in the Organ System-based Medical Curriculum
Authors: Zhu Yaxi , Liu Lingyun , Wang Hao , Lv Qinglan , Tan Sipin , Jiang Bimei , Xiao Zihui , Xiong Wei , Liu Ying , Zhang Huali 
Published: March 2023

Abstract
BACKGROUND
The organ system-based medical curriculum is crucial for students in the MD-PhD program of Xiangya School of Medicine at Central South University in China. The combination of Team Based Learning (TBL) and Problem Based Learning (PBL) forms a new case-based teaching model so that students can cooperatively participate in case discussions using multi-disciplinary knowledge. The aim of this study is to utilize TBL-PBL teaching model in the organ system-based medical curriculum, and assess the feedback on teaching arrangement, effectiveness and the academic performance of students.
METHODS
This is a single institution, two-year study that includes two cohorts of students who participated in two training paradigms, traditional teaching model and TBL-PBL teaching modal. The MD-PhD students enrolled in 2016 (n=100) were selected for traditional teaching model, students enrolled in 2017 (n=100) were selected for TBL-PBL teaching model, in which the learning contents were remodeled and integrated with simulated cases, taught by an interprofessional team. After completing the curriculmn, all students were surveyed on their feedbacks about group teaching arrangement and teaching effectiveness. Academic performance were also assesses by post-session quizzes, periodical tests and the final exams.
RESULTS
The survey results revealed that in the TBL-PBL teaching group, the percentage of students who thought that the teaching objectives were challenging reached 94%. Meanwhile, for the traditional teaching group, the percentage of students who thought likewise were 84%. The percentage of students in the TBL-PBL group who thought that the innovative teaching mode rendered helpful in consolidating basic medical knowledge structure (89% vs. 78%), promoted student overall thinking skills (94% vs. 84%), communication skills(93% vs. 82%), teamwork skills (95% vs. 82%) and professional abilities (89% vs. 84%) outweighed the traditional teaching group to a significant degree. The academic performance in the TBL-PBL group was improved evidenced by higher class scores(85.52 vs. 80.34), excellence rate (51% vs. 49%) and qualification rate (100% vs. 92%).
CONCLUSION
The TBL-PBL teaching model improved academic performance, yielded higher student satisfaction and engagement. This innovative teaching model can be used as an alternative to traditional model for medical courses.
Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center
Authors: Zhu Caixia , Cai Shiqin , Zhong Xue , Zhang Shaofeng , Shen Lixia , Ye Lisha , Zhan Minjin , Huang Jingwan , Wang Zilian , Chen Haitian 
Published: March 2023

Abstract
Background Adrenal adenoma during pregnancy is rare and the diagnosis is challenging owing to unspecific symdromes and restricted investigation. It’s poorly described obstetric outcomes of patients underwent surgery during pregnancy or only received medicine treatment. To report the clinical characteristics and obstetric outcomes of pregnant women complicated with adrenal adenoma.
Methods A retrospective study was performed. The clinical characteristics, management and obstetric outcome of pregnancies diagnosed as adrenal adenoma over 20 years were reviewed from a teriary hospital.
Results A total of 12 women were diagnosed as adrenal adenoma during pregnancy from to January 2000 to September 2022. Eight women had cortisol-secreting adrenal adenoma, two had over-secrete catecholamine and two primary aldosteronism. The original symptoms adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or pre-pregnancy diabetes mellitus, hypokalemia and ecchymosis. There were four women took adrenalectomy during pregnancy, while 8 women only received medicine therapy. Preterm birth occurred in all cases who received medicine, whereas 1 case suffered from preterm birth in the group underwent surgery. Among the 8 women of medicine group, there were 3 neonatal death.
Conclusions Once simultaneous onset of hypertension, hyperglycemia and hypokalemia during the 1st or 2nd trimester, adrenal adenoma should be investigate by laboratory examination and imaging examination. The maternal and fetal outcome were unpredictive owing to the severity of adrenal adenoma, particular in patients only received medicine treatment. Adrenalectomy should be recommended during the pregnancy.
Psychological distress, social media use, and academic performance of medical students: The mediating role of coping style
Authors: Shiraly Ramin , Roshanfekr Ashrafalsadat , Griffiths Mark D. 
Published: March 2023

Abstract

Background
Given that social media use is an increasingly widespread activity among university students, more information is needed to evaluate its potential implications for students’ mental health.
Objective
The present study assessed the effect of interaction between coping style and social media use on psychological distress and academic performance among medical students.
Methods
A total of 400 undergraduate students from a large Iranian medical university participated in the study. A self-administered survey was used to collect data on demographics, negative emotional states (DASS-21), coping strategies (Brief COPE scale), academic performance (by grade point average) and estimated average time spent on social media per day. Multiple linear regression models were used to examine relationships between the study variables.
Results
Psychological distress was common among medical students, with depressed mood being the most common (44%). Based on DASS-21 scores, students with higher levels of psychological distress were more likely to be engaged in frequent social media use. More than two hours per day social media use showed positive association with maladaptive coping (p < 0.001) (particularly with self-distraction and behavioral disengagement components) but no significant association with adaptive coping (p = 0.876). No significant associations were found between psychological distress and average time spent on social media use with students’ academic performance. Mediation analysis showed that the effect of social media use on students’ psychological distress was totally mediated by maladaptive coping.
Conclusion
The findings suggest that social media use influences students’ emotional states indirectly through their coping style. It may act as a maladaptive approach to cope with mental distress mostly via self-distraction and behavior disengagement.
CO2 holdup monitoring, ruminal acidosis might be caused by CO2 poisoning
Authors: Laporte-Uribe Jose 
Published: March 2023

Abstract
Ruminal CO2 holdup or high dissolved CO2 concentrations (dCO2) for long postprandial periods might increase CO2 absorption and the risk of CO2 poisoning. Ruminal pH and dCO2 are intertwined, explaining why ruminal acidosis is ascribed to low ruminal pH, which is a spurious relationship. Here, the use of an ATR-IR spectrometer to monitor ruminal dCO2 is described. Three fistulated lactating dairy cattle were exposed to diets tailored to increase both dCO2 and the risk of subacute ruminal acidosis (SARA). Indwelling pH sensors and ruminal fluid samples were used as references, and a categorical analysis based on the Gaussian distribution of the ruminal dCO2 was applied to detect CO2 holdup. The milk yield, milk components and feed intake supported a positive role for high dCO2 on rumen function. However, SARA was associated with CO2 holdup, viz. sustaining critical ruminal dCO2 for extended postprandial periods. Therefore, SARA was most likely a sign of CO2 poisoning rather than a pH decline. Monitoring ruminal dCO2 with the proposed categorical analysis might help us to optimise rumen function and reduce the risk of ruminal acidosis.
Resting-state brain plasticity is associated with the severity in Cervical Spondylotic Myelopathy
Authors: Tan# Yongming , Shao# Ziwei , Wu Kaifu , Zhou Fuqing , He Laichang 
Published: March 2023

Abstract
Objective: To determine if cortical activity differences measured by fMRI were associated with the severity of clinical symptoms in patients with cervical spondylotic myelopathy (CSM).
Methods: We recruited 40 patients with CSM (22 mild-moderate CSM, 18 severe CSM), and 25 healthy controls (HCs) matched with age, sex and education status. Clinical data (Japanese Orthopedic Association Score [JOA] and Neck Disability Index [NDI]) and 3.0T MRI parameters including DTI at the spinal cord (level C2/3) with fractional anisotropy (FA) and degree centrality (DC) were recorded. Pearson correlation analysis was then separately performed between JOA with FA and DC.
Results: Among them, degree centrality value of left middle temporal gyrus exhibited a progressive increase in CSM groups compared with HCs, the DC value in severe CSM group was higher compared with mild-moderate CSM group. (P<0.05), and the DC values of the right superior temporal gyrus and precuneus showed a decrease after increase. Among them, DC values in the area of precuneus in severe CSM group were significantly lower than those in mild-moderate CSM and HCs. (P<0.05). The fractional anisotropy (FA) values of the level C2/3 showed a progressive decrease in different clinical stages, that severe CSM group was the lowest, significantly lower than those in mild-moderate CSM and HCs (P<0.05). There was negative correlation between DC value of left middle temporal gyrus and JOA scores (P<0.001), and the FA values of dorsal column in the level C2/3 positively correlated with the JOA scores (P<0.001).
Conclusion: Structural and functional changes have taken place in the cervical spinal cord and brain of CSM patients. The Brain reorganization plays an important role in maintaining the symptoms and signs of CSM, aberrant DC values in the left middle temporal gyrus may be the possible mechanism of inconsistency between imaging findings and clinical symptoms. Degree centrality is a potentially useful prognostic functional biomarker in cervical spondylotic myelopathy.
Study on the diagnostic value of folic acid-targeted nano-microbubbles in breast microcarcinoma
Authors: Xue Nianyu , Shen Zhenyu , Xu Zhenbin , Zhang Shengmin 
Published: March 2023

Abstract
Background
The prognosis of breast cancer is significantly correlated with its early detection. It is difficult to detect breast microcarcinomas less than or equal to 5 mm by imaging examination.
Methods
Folic acid-targeted nanobubbles (FA-TNBs) were prepared by the thin-film hydration method. Cytotoxicity and cellular uptake assays were used to examine FA-TNBs’ biological toxicity to cells, targeting them to breast cancer cells. In addition, by constructing a mouse 4T1 tumor model and evaluating the targeting and imaging effects of FA-TNBs, the diagnostic value of these microbubbles for breast microcarcinomas (diameter ≤ 5 mm) was evaluated.
Results
The average particle size of the fabricated FA-TNBs was 244 ± 21 nm. In vitro cell uptake experiments showed that breast cancer 4T1 cells take up more FA-TNBs than non-targeted nanobubbles (N-TNBs) (p < 0.001). In the cytotoxicity experiment, the survival rate of 4T1 cells under each FA-NBs concentration was > 90%. In vivo imaging of the mouse 4T1 tumor model showed that compared with the N-TNBs group, the FA-TNBs group took a shorter time to peak (20 s, 40 s, p < 0.05), had a higher peak intensity (38.3 ± 1.5 dB, 31.7 ± 1.5 dB, p < 0.05), and the extinction time was shorter (180 s, 120 s, p < 0.05). After FA-NB injection, there were no apparent abnormalities in the tissue sections or hematological examinations of the mice’s vital organs.
Conclusions
The prepared FA-TNBs had good water solubility, safety, biocompatibility, and enhancement of ultrasound imaging. It had a good imaging effect on mouse breast cancer tumors with a diameter of 5 mm and showed apparent active targeting. FA-TNBs may become a new and practical ultrasound contrast agent for the early detection of breast cancer.