bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of Quality Talk to foster critical thinking in a low socio-economic secondary Geography classroom
Authors: Davies Maree J. , Esling Simon 
Published: January 2023

AbstractThis small case study investigated the use of the Quality Talk framework to empower students to pool their knowledge in group discussions around a novel topic or event. The main goals of the Quality Talk approach were to provide teachers with a prescriptive framework for increasing their students’ critical-analytical thinking by providing greater opportunity for student voice. The quasi-experimental methodology involved students and a teacher from a low socioeconomic secondary school in a large city in New Zealand in the curriculum area of Geography. The students, on self-report, identified as coming from predominantly Pasifika backgrounds. Following the intervention and additional opportunities to conduct group discussions, many of the students identified how other opinions contributed to their understanding of the topic. An episode of talk is considered a ‘dialogic spell’, rather than a discussion, if the discussion begins with a student’s question and is followed by at least two more questions from other students. When students used higher numbers of uptake questions and high-level questions, they increased their levels of ‘dialogic spell’. The students’ increase of critical-analytical thinking in their pre- and post-test was assessed and graded. The study was important because it also showed that when the teacher relinquished their role as facilitator of the discussions, the students self-facilitated the dialogue amongst themselves.
Mono(2-ethylhexyl) phthalate induces transcriptomic changes in placental cells based on concentration, fetal sex, and trophoblast cell type
Authors: Lapehn Samantha , Houghtaling Scott , Ahuna Kylia , Kadam Leena , MacDonald James W. , Bammler Theo K. , LeWinn Kaja Z. , Myatt Leslie , Sathyanarayana Sheela , Paquette Alison G. 
Published: January 2023

AbstractPhthalates are ubiquitous plasticizer chemicals found in consumer products. Exposure to phthalates during pregnancy has been associated with adverse pregnancy and birth outcomes and differences in placental gene expression in human studies. The objective of this research was to evaluate global changes in placental gene expression via RNA sequencing in two placental cell models following exposure to the phthalate metabolite mono(2-ethylhexyl) phthalate (MEHP). HTR-8/SVneo and primary syncytiotrophoblast cells were exposed to three concentrations (1, 90, 180 µM) of MEHP for 24 h with DMSO (0.1%) as a vehicle control. mRNA and lncRNAs were quantified using paired-end RNA sequencing, followed by identification of differentially expressed genes (DEGs), significant KEGG pathways, and enriched transcription factors (TFs). MEHP caused gene expression changes across all concentrations for HTR-8/SVneo and primary syncytiotrophoblast cells. Sex-stratified analysis of primary cells identified different patterns of sensitivity in response to MEHP dose by sex, with male placentas being more responsive to MEHP exposure. Pathway analysis identified 11 KEGG pathways significantly associated with at least one concentration in both cell types. Four ligand-inducible nuclear hormone TFs (PPARG, PPARD, ESR1, AR) were enriched in at least three treatment groups. Overall, we demonstrated that MEHP differentially affects placental gene expression based on concentration, fetal sex, and trophoblast cell type. This study confirms prior studies, as enrichment of nuclear hormone receptor TFs were concordant with previously published mechanisms of phthalate disruption, and generates new hypotheses, as we identified many pathways and genes not previously linked to phthalate exposure.
Probabilistically nilpotent groups of class two
Authors: Eberhard Sean , Shumyatsky Pavel 
Published: January 2023

AbstractFor G a finite group, let $$d_2(G)$$

d
2

(
G
)

denote the proportion of triples $$(x, y, z) \in G^3$$

(
x
,
y
,
z
)

∈

G
3

such that $$[x, y, z] = 1$$

[
x
,
y
,
z
]
=
1

. We determine the structure of finite groups G such that $$d_2(G)$$

d
2

(
G
)

is bounded away from zero: if $$d_2(G) \ge \epsilon > 0$$

d
2

(
G
)

≥
ϵ
>
0

, G has a class-4 nilpotent normal subgroup H such that [G : H] and $$|\gamma _4(H)|$$

|

γ
4

(
H
)

|

are both bounded in terms of $$\epsilon $$
ϵ
. We also show that if G is an infinite group whose commutators have boundedly many conjugates, or indeed if G satisfies a certain more general commutator covering condition, then G is finite-by-class-3-nilpotent-by-finite.
Unitarity of Minimal W-Algebras and Their Representations I
Authors: Kac Victor G. , Möseneder Frajria Pierluigi , Papi Paolo 
Published: January 2023

AbstractWe begin a systematic study of unitary representations of minimal W-algebras. In particular, we classify unitary minimal W-algebras and make substantial progress in classification of their unitary irreducible highest weight modules. We also compute the characters of these modules.
Endomorphisms of the projective plane and the image of the Suslin–Hurewicz map
Authors: Röndigs Oliver 
Published: January 2023

AbstractThe endomorphism ring of the projective plane over a field F of characteristic neither two nor three is slightly more complicated in the Morel–Voevodsky motivic stable homotopy category than in Voevodsky’s derived category of motives. In particular, it is not commutative precisely if there exists a square in F which does not admit a sixth root. A byproduct of these computations is a proof of Suslin’s conjecture on the Suslin–Hurewicz homomorphism from Quillen to Milnor K-theory in degree four, based on work of Asok et al. (Invent Math 219:39-73, 2020).
Transfemoral Perimembranous Ventricular Septal Defect Device Closure in Infants Weighing ≤ 10 kg
Authors: Alshahrani Dhafer , Linnane Niall , McCrossan Brian , Oslizlok Paul , McMahon Colin J. , Walsh Kevin P. , Kenny Damien P. 
Published: January 2023

AbstractTranscatheter closure of Perimembranous VSDs (PMVSD) remains challenging particularly in infants. The aim of this study is to evaluate the efficacy and safety of transfemoral PMVSD device closure in infants weighing ≤ 10 kg in a single centre. Retrospective review of departmental databases and medical charts to define patient cohort and collect demographic, procedural and follow-up data. Between July 2014 and March 2021, 16 patients underwent attempted transfemoral PMVSD device closure (12 retrograde) at a median age of 11 months (interquartile range [IQR] 9–15.5) and a median weight of 8.3 kg (IQR 7.2–9.5). All patients were either symptomatic, had progressive left heart dilation or had VSD associated valve regurgitation. Median defect size on pre-procedural transoesophageal echocardiography was 6.8 mm (IQR 6–8.5). Median device waist size was 6 mm (IQR 4.5–8). Successful device placement was achieved in 14 patients (88%). One patient developed moderate aortic and tricuspid valve regurgitation upon retrograde and antegrade device deployment, respectively, and subsequently underwent surgical closure. The second patient developed progressive aortic regurgitation (AR) 2 days post procedure, and also underwent surgical removal with no residual AR. There was no cases of device embolization and no femoral arterial compromise. On median follow-up of 40.5 months (IQR 25–64), none of the patients developed complete heart block. Three patients (18.75%) had small residual shunts at latest follow-up which have not required any further intervention. Device closure of PMVSD’s in children weighing ≤ 10 kg is feasible and safe with good procedural success rates. Use of both the antegrade and retrograde approaches may be necessary depending on anatomical variances.
Association of Surgical Timing with Outcomes in Early Stage Lung Cancer
Authors: Banks Kian C. , Dusendang Jennifer R. , Schmittdiel Julie A. , Hsu Diana S. , Ashiku Simon K. , Patel Ashish R. , Sakoda Lori C. , Velotta Jeffrey B. 
Published: January 2023

AbstractBackgroundOptimal time to surgery for lung cancer is not well established. We aimed to assess whether time to surgery correlates with outcomes.MethodsWe assessed patients 18–84 years old who were diagnosed with stage I/II lung cancer at our integrated healthcare system from 2009 to 2019. Time to surgery was defined to start with disease confirmation (imaging or biopsy) prior to the surgery scheduling date. Outcomes of unplanned return to care within 30 days of lung cancer surgery, all‐cause mortality, and disease recurrence were compared based on time to surgery before and after 2, 4, and 12 weeks.ResultsOf 2861 included patients, 70% were over 65 years old and 61% were female. Time to surgery occurred in 1–2 weeks for 6%, 3–4 weeks for 31%, 5–12 weeks for 58%, and 13–26 weeks for 5% of patients. Patients with time to surgery > 4 (vs. ≤ 4) weeks had greater risk of both death (hazard ratio (HR) 1.18, 95% confidence interval (CI) 1.00–1.39) and recurrence (HR 1.33, 95% CI 1.10–1.62). Associations were not statistically significant when dichotomizing time to surgery at 2 or 12 weeks for death (2 week HR 1.23, 95% CI 0.93–1.64; 12 week HR 1.35, 95% CI 0.97–1.88) and recurrence (2 week HR 1.54, 95% CI 0.85–2.80; 12 week HR 2.28, 95% CI 0.80–6.46).ConclusionsEarly stage lung cancer patients with time to surgery within 4 weeks experienced lower rates of recurrence. Optimal time to surgical resection may be shorter than previously reported.
An accessory muscle belly or an accessory muscle head? An unusual arrangement of muscles in the anterior compartment of the forearm
Authors: Gabríková Klára , Kachlík David , Belbl Miroslav , Kunc Vojtěch 
Published: January 2023

Abstract
Purpose
Knowledge of the unusual arrangement of the flexor pollicis longus (FPL) muscle is important as the variable tendon may be a rare cause of carpal tunnel syndrome.

Methods
During a routine dissection at the Department of Anatomy, an unusual formation of the FPL muscle was observed in a formalin embalmed Central European cadaver.

Results
This report presents a variation of the FPL muscle, where the muscle split and formed a separate accessory head inserting into the first lumbrical muscle. Moreover, a tendinous interconnection was present between the FPL muscle tendon and the tendon of the aberrant muscle head.

Conclusion
The cases described by previous literature, concerning the Linburg–Comstock variation or the accessory head of the first lumbrical muscle originating from the FPL muscle, are closest to the present case. Such variation has a clinical significance ranging from the functional limitation of the thumb and index finger movement to the potential median nerve compression.
Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study
Authors: Niederwieser Dietger , Lang Thomas , Krahl Rainer , Heinicke Thomas , Maschmeyer Georg , Al-Ali Haifa Kathrin , Schwind Sebastian , Jentzsch Madlen , Cross Michael , Kahl Christoph , Wolf Hans-Heinrich , Sayer Herbert , Schulze Antje , Dreger Peter , Hegenbart Ute , Krämer Alwin , Junghanss Christian , Mügge Lars-Olof , Hähling Detlev , Hirt Carsten , Späth Christian , Peter Norma , Opitz Bernhard , Florschütz Axel , Reifenrath Kolja , Zojer Niklas , Scholl Sebastian , Pönisch Wolfram , Heyn Simone , Vucinic Vladan , Hochhaus Andreas , Aul Carlo , Giagounidis Aristoteles , Balleisen Leopold , Oldenkott Bernd , Staib Peter , Kiehl Michael , Schütte Wolfgang , Naumann Ralph , Eimermacher Hartmut , Dörken Bernd , Sauerland Cristina , Lengfelder Eva , Hiddemann Wolfgang , Wörmann Bernhard , Müller-Tidow Carsten , Serve Hubert , Schliemann Christoph , Hehlmann Rüdiger , Berdel Wolfgang E. , Pfirrmann Markus , Krug Utz , Hoffmann Verena S. 
Published: January 2023

AbstractA randomized inter-group trial comparing more intensive treatment strategies to a common standard arm 3 + 7 (CSA) was conducted in patients with non-M3 AML. Untreated patients ≥ 60 years were allocated to the CSA (n = 132) or to the study group arms (n = 1154) of the AMLCG (TAD/HAM versus HAM/HAM ± G-CSF followed by TAD and maintenance) and the OSHO (intermediate-dose ara-C/mitoxantrone followed by ara-C/mitoxantrone). Median age of the 1147 eligible patients was 69 (range 60–87) years. CR/CRi status at 90 days was not significantly different between the CSA (54% (95%CI: 45–64)) and the study group arms (53% (95%CI: 47–60) and 59% (95%CI: 58–63)). The five-year event-free survival (EFS) probability (primary endpoint) was 6.2% (95%CI: 2.7–14.0) in the CSA, 7.6% (95%CI: 4.5–12.8) in study group A and 11.1% (95%CI: 9.0–13.7) in B. The 5-year OS was 17.2% (95%CI: 11.0–26.9), 17.0% (95%CI: 2.0–23.9), and 19.5% (95%CI: 16.7–22.8) in CSA, study group A and B, respectively. Neither study group differed significantly from the CSA regarding EFS, OS, or relapse-free survival. In multivariate analyses, allocation to the treatment strategy was not significantly associated with the time-to-event endpoints. The evaluation of more intensive treatment strategies did not show clinically relevant outcome differences when compared to CSA.
Scalable computational kernels for mortar finite element methods
Authors: Mayr Matthias , Popp Alexander 
Published: January 2023

AbstractTargeting simulations on parallel hardware architectures, this paper presents computational kernels for efficient computations in mortar finite element methods. Mortar methods enable a variationally consistent imposition of coupling conditions at high accuracy, but come with considerable numerical effort and cost for the evaluation of the mortar integrals to compute the coupling operators. In this paper, we identify bottlenecks in parallel data layout and domain decomposition that hinder an efficient evaluation of the mortar integrals. We then propose a set of computational strategies to restore optimal parallel communication and scalability for the core kernels devoted to the evaluation of mortar terms. We exemplarily study the proposed algorithmic components in the context of three-dimensional large-deformation contact mechanics, both for cases with fixed and dynamically varying interface topology, yet these concepts can naturally and easily be transferred to other mortar applications, e.g. classical meshtying problems. To restore parallel scalability, we employ overlapping domain decompositions of the interface discretization independent from the underlying volumes and then tackle parallel communication for the mortar evaluation by a geometrically motivated reduction of ghosting data. Using three-dimensional contact examples, we demonstrate strong and weak scalability of the proposed algorithms up to 480 parallel processes as well as study and discuss improvements in parallel communication related to mortar finite element methods. For the first time, dynamic load balancing is applied to mortar contact problems with evolving contact zones, such that the computational work is well balanced among all parallel processors independent of the current state of the simulation.
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
Authors: Churm Rachel , Williams Liam M. , Dunseath Gareth , Prior Sarah L. , Bracken Richard M. 
Published: January 2023

Abstract
Purpose
Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans.

Methods
Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26).

Results
Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS).

Conclusion
Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate.
Health-related quality of life after robotic surgery for endometrial cancer: a prospective longitudinal one-year follow-up study
Authors: Lindfors Anna , Järvholm Stina , Dahm-Kähler Pernilla 
Published: January 2023

AbstractPurposeThis study aimed to explore how patients treated for endometrial cancer (EC) with robotic surgery are affected in symptoms of anxiety and depression and HRQoL in the long term.MethodsWomen scheduled for primary robotic surgery for EC were included (n = 64), in this single-center study. Socioeconomic variables were obtained at baseline. The European Organization for Research and Treatment of Cancers Quality of Life Questionnaire Core 30 (QLQ-C30), its module for EC (EN24), the Generalized Anxiety Disorder Scale (GAD-7), and the Patient Health Questionnaire Depression Scale (PHQ-9) were followed prospectively from baseline to 2 weeks, 3 months and 1 year postoperatively.ResultsThe number of patients scoring above the clinical threshold for anxiety decreased from 17 (27.0%) at baseline to 4 (7.0%) at 2 weeks (p = 0.012). Depressive symptoms were reported in 20% of patients at baseline and did not change significantly during the one-year follow-up (p = 0.58). A significant decrease in Global health status was seen at 2 weeks (from 69.8 to 62.7;p = 0.048), with return to baseline levels after 3 months (68.5;p = 0.32) and stable at 1 year. Unemployment, low income, and adjuvant therapy correlated with lower Global health status at 3 months.ConclusionThe significant proportion of patients with anxiety symptoms preoperatively reduced prompt after surgery, while the proportion with depression remained constant, indicating that the primary treatment has no long-term negative effect on patients’ mental health. At 3 months, there is no obvious remaining negative impact on patients’ HRQoL, and these results are consistent after 1 year.
Association between malformation type, location and functional deficits in lymphatic malformations of the head and neck in children
Authors: Wiegand Susanne , Wichmann G. , Dietz A. , Werner J. A. 
Published: January 2023

Abstract
Purpose
Lymphatic malformations (LM) are congenital malformations of the lymphatic system, mainly located in the head and neck area. They can be staged based on location according to de Serres and based on different morbidity items using the Cologne Disease Score (CDS), a clinical staging system. In many cases, functional impairment greatly affects the life of patients suffering from lymphatic malformations. The present study aims to analyze a cohort of pediatric patients with LM.

Methods
A retrospective analysis of 144 pediatric patients with head and neck LM was performed. Location, type of malformation (microcystic, macrocystic, mixed), scoring according to two different scoring systems and therapy were analyzed. Kruskal–Wallis test was used to analyze the difference in CDS between the patient groups and Dunn’s test was used for post-hoc pairwise comparison.

Results
The average age at presentation was 6.1 years. The most common sites were neck (47%), cheek/parotid gland (26%), tongue (17%) and orbit (8%). Macrocystic malformations dominated the lateral neck, while microcystic malformations were predominantly localized in the tongue and floor of mouth. Macrocystic malformations (mean CDS 9.44) were associated with significantly better CDS than microcystic (mean CDS 7.11) and mixed (mean CDS 5.71) malformations (p < 0.001). LM in stage V according to de Serres had the lowest values (mean CDS: 4.26). The most common therapeutic procedures were conventional surgical (partial) resection, laser therapy and sclerotherapy with OK-432.

Conclusions
There is an association between malformation type, location according to de Serres and CDS in children with LM of the head and neck. Patients with microcystic and mixed malformations in stage V had lowest CDS levels.
Effect of interaural electrode insertion depth difference and independent band selection on sentence recognition in noise and spatial release from masking in simulated bilateral cochlear implant listening
Authors: Fathima Hasna , Bhat Jayashree S. , Pitchaimuthu Arivudai Nambi 
Published: January 2023

Abstract
Purpose
Inter-aural insertion depth difference (IEDD) in bilateral cochlear implant (BiCI) with continuous interleaved sampling (CIS) processing is known to reduce the recognition of speech in noise and spatial release from masking (SRM). However, the independent channel selection in the ‘n-of-m’ sound coding strategy might have a different effect on speech recognition and SRM when compared to the effects of IEDD in CIS-based findings. This study aimed to investigate the effect of bilateral ‘n-of-m’ processing strategy and interaural electrode insertion depth difference on speech recognition in noise and SRM under conditions that simulated bilateral cochlear implant listening.

Methods
Five young adults with normal hearing sensitivity participated in the study. The target sentences were spatially filtered to originate from 0° and the masker was spatially filtered at 0°, 15°, 37.5°, and 90° using the Oldenburg head-related transfer function database for behind the ear microphone. A 22-channel sine wave vocoder processing based on ‘n-of-m’ processing was applied to the spatialized target-masker mixture, in each ear. The perceptual experiment involved a test of speech recognition in noise under one co-located condition (target and masker at 0°) and three spatially separated conditions (target at 0°, masker at 15°, 37.5°, or 90° to the right ear).

Results
The results were analyzed using a three-way repeated measure analysis of variance (ANOVA). The effect of interaural insertion depth difference (F (2,8) = 3.145, p = 0.098, ɳ2 = 0.007) and spatial separation between target and masker (F (3,12) = 1.239, p = 0.339, ɳ2 = 0.004) on speech recognition in noise was not significant.

Conclusions
Speech recognition in noise and SRM were not affected by IEDD ≤ 3 mm. Bilateral ‘n-of-m’ processing resulted in reduced speech recognition in noise and SRM.