bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long axial field of view (LAFOV) PET-CT: implementation in static and dynamic oncological studies
Authors: Dimitrakopoulou-Strauss Antonia , Pan Leyun , Sachpekidis Christos 
Published: April 2023

AbstractLong axial field of view (LAFOV) PET-CT scanners have been recently developed and are already in clinical use in few centers worldwide. Although still limited, the hitherto acquired experience with these novel systems highlights an increased sensitivity as their main advantage, which results in an increased lesion detectability. This attribute, alternatively, allows a reduction in PET acquisition time and/or administered radiotracer dose, while it renders delayed scanning of satisfying diagnostic accuracy possible. Another potential advantage of the new generation scanners is CT-less approaches for attenuation correction with the impact of marked reduction of radiation exposure, which may in turn lead to greater acceptance of longitudinal PET studies in the oncological setting. Further, the possibility for the first time of whole-body dynamic imaging, improved compartment modeling, and whole-body parametric imaging represent unique characteristics of the LAFOV PET-CT scanners. On the other hand, the advent of the novel LAFOV scanners is linked to specific challenges, such as the high purchase price and issues related to logistics and their optimal operation in a nuclear medicine department. Moreover, with regard to its research applications in oncology, the full potential of the new scanners can only be reached if different radiopharmaceuticals, both short and long-lived ones, as well as novel tracers, are available for use, which would, in turn, require the appropriate infrastructure in the area of radiochemistry. Although the novel LAFOV scanners are not yet widely used, this development represents an important step in the evolution of molecular imaging. This review presents the advantages and challenges of LAFOV PET-CT imaging for oncological applications with respect to static and dynamic acquisition protocols as well as to new tracers, while it provides an overview of the literature in the field.
Efficacy and safety of nilotinib as frontline treatment in elderly (> 65 years) chronic myeloid leukemia patients outside clinical trials
Authors: Luciano Luigia , Latagliata Roberto , Gugliotta Gabriele , Annunziata Mario , Tiribelli Mario , Martino Bruno , Sica Antonello , Esposito Maria Rosaria , Bocchia Monica , Galimberti Sara , Sorà Federica , Albano Francesco , Palmieri Raffaele , Pregno Patrizia , Dragani Matteo , Iovine Maria , Sica Simona , Iurlo Alessandra , Castagnetti Fausto , Rosti Gianantonio , Breccia Massimo 
Published: April 2023

AbstractHere, we report real-world evidence on the safety and efficacy of nilotinib as a first-line treatment in elderly patients with chronic phase CML, treated in 18 Italian centers. Sixty patients aged > 65 years (median age 72 years (65–84)) were reported: 13 patients were older than 75 years. Comorbidities were recorded at baseline in 56/60 patients. At 3 months of treatment, all patients obtained complete hematological response (CHR), 43 (71.6%) an early molecular response (EMR), while 47 (78%) reached a complete cytogenetic response (CCyR). At last follow-up, 63.4% of patients still had a deep molecular response (MR4 or better), 21.6% reached MR3 as best response and 11.6% persisted without MR. Most patients (85%) started the treatment at the standard dose (300 mg BID), maintained at 3 months in 80% of patients and at 6 months in 89% of them. At the last median follow-up of 46.3 months, 15 patients discontinued definitively the treatment (8 due to side effects, 4 died for unrelated CML causes, 1 for failure, 2 were lost to follow-up). One patient entered in treatment-free remission. As to safety, 6 patients (10%) experienced cardiovascular events after a median time of 20.9 months from the start. Our data showed that nilotinib could be, as first-line treatment, effective and relatively safe even in elderly CML patients. In this setting, more data in the long term are needed about possible dose reduction to improve the tolerability, while maintaining the optimal molecular response.
Validating real-time three-dimensional echocardiography against cardiac magnetic resonance, for the determination of ventricular mass, volume and ejection fraction: a meta-analysis
Authors: Dissabandara Thilini , Lin Kelly , Forwood Mark , Sun Jing 
Published: April 2023

Abstract
Introduction
Real-time three-dimensional echocardiography (RT3DE) is currently being developed to overcome the challenges of two-dimensional echocardiography, as it is a much cheaper alternative to the gold standard imaging method, cardiac magnetic resonance (CMR). The aim of this meta-analysis is to validate RT3DE by comparing it to CMR, to ascertain whether it is a practical imaging method for routine clinical use.

Methods
A systematic review and meta-analysis method was used to synthesise the evidence and studies published between 2000 and 2021 were searched using a PRISMA approach. Study outcomes included left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), left ventricular mass (LVM), right ventricular end-systolic volume (RVESV), right ventricular end-diastolic volume (RVEDV) and right ventricular ejection fraction (RVEF). Subgroup analysis included study quality (high, moderate), disease outcomes (disease, healthy and disease), age group (50 years old and under, over 50 years), imaging plane (biplane, multiplane) and publication year (2010 and earlier, after 2010) to determine whether they explained the heterogeneity and significant difference results generated on RT3DE compared to CMR.

Results
The pooled mean differences for were − 5.064 (95% CI − 10.132, 0.004, p > 0.05), 4.654 (95% CI − 4.947, 14.255, p > 0.05), − 0.783 (95% CI − 5.630, 4.065, p > 0.05, − 0.200 (95% CI − 1.215, 0.815, p > 0.05) for LVEF, LVM, RVESV and RVEF, respectively. We found no significant difference between RT3DE and CMR for these variables. Although, there was a significant difference between RT3DE and CMR for LVESV, LVEDV and RVEDV where RT3DE reports a lower value. Subgroup analysis indicated a significant difference between RT3DE and CMR for studies with participants with an average age of over 50 years but no significant difference for those under 50. In addition, a significant difference between RT3DE and CMR was found in studies using only participants with cardiovascular diseases but not in those using a combination of diseased and healthy participants. Furthermore, for the variables LVESV and LVEDV, the multiplane method shows no significant difference between RT3DE and CMR, as opposed to the biplane showing a significant difference. This potentially indicates that increased age, the presence of cardiovascular disease and the biplane analysis method decrease its concordance with CMR.

Conclusion
This meta-analysis indicates promising results for the use of RT3DE, with limited difference to CMR. Although in some cases, RT3DE appears to underestimate volume, ejection fraction and mass when compared to CMR. Further research is required in terms of imaging method and technology to validate RT3DE for routine clinical use.

Graphical abstract
The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours
Authors: Hannon Barroeta Patricia , O’Sullivan Maureen J. , Zisterer Daniela M. 
Published: April 2023

Abstract
Purpose
Malignant rhabdoid tumour (MRT) is a rare and aggressive childhood malignancy that occurs in the kidneys or central nervous system and is associated with very poor prognosis. Chemoresistance is a major issue in the treatment of this malignancy leading to an urgent need for a greater understanding of its underlying mechanisms in MRT and novel treatment strategies for MRT patients. The balance between oxidative stress mediated by reactive oxygen species (ROS) and the antioxidant system has become a subject of interest in cancer therapy research. Studies have implicated key players of the antioxidant system in chemotherapeutic including the well-known antioxidant glutathione (GSH) and the transcription factor nuclear erythroid-related factor-2 (Nrf2).

Methods
This study evaluated the role of these components in the response of MRT cells to treatment with the commonly used chemotherapeutic agent, cisplatin.

Results
This study characterised the basal levels of GSH, ROS and Nrf2 in a panel of MRT cell lines and found a correlation between the expression profile of the antioxidant defence system and cisplatin sensitivity. Results showed that treatment with ROS scavenger N-acetylcysteine (NAC) protected cells from cisplatin-induced ROS and apoptosis. Interestingly, depleting GSH levels with the inhibitor buthionine sulphoximine (BSO) enhanced cisplatin-induced ROS and sensitised cells to cisplatin. Lastly, targeting Nrf2 with the small molecule inhibitor ML385 or by siRNA diminished GSH levels, enhanced ROS and sensitised resistant MRT cells to cisplatin.

Conclusions
These results suggest that targeting the Nrf2/GSH antioxidant system may present a novel therapeutic strategy to combat chemoresistance in rhabdoid tumours.
Magnetic resonance imaging at 9.4 T: the Maastricht journey
Authors: Ivanov Dimo , De Martino Federico , Formisano Elia , Fritz Francisco J. , Goebel Rainer , Huber Laurentius , Kashyap Sriranga , Kemper Valentin G. , Kurban Denizhan , Roebroeck Alard , Sengupta Shubharthi , Sorger Bettina , Tse Desmond H. Y. , Uludağ Kâmil , Wiggins Christopher J. , Poser Benedikt A. 
Published: April 2023

AbstractThe 9.4 T scanner in Maastricht is a whole-body magnet with head gradients and parallel RF transmit capability. At the time of the design, it was conceptualized to be one of the best fMRI scanners in the world, but it has also been used for anatomical and diffusion imaging. 9.4 T offers increases in sensitivity and contrast, but the technical ultra-high field (UHF) challenges, such as field inhomogeneities and constraints set by RF power deposition, are exacerbated compared to 7 T. This article reviews some of the 9.4 T work done in Maastricht. Functional imaging experiments included blood oxygenation level-dependent (BOLD) and blood-volume weighted (VASO) fMRI using different readouts. BOLD benefits from shorter T2* at 9.4 T while VASO from longer T1. We show examples of both ex vivo and in vivo anatomical imaging. For many applications, pTx and optimized coils are essential to harness the full potential of 9.4 T. Our experience shows that, while considerable effort was required compared to our 7 T scanner, we could obtain high-quality anatomical and functional data, which illustrates the potential of MR acquisitions at even higher field strengths. The practical challenges of working with a relatively unique system are also discussed.
Das Vorliegen eines “vernünftigen Grundes” bei der Tötung überzähliger Versuchstiere
Authors: Wagenknecht Tobias , Eusemann Beryl , Schwedhelm Philipp , Schönfelder Gilbert , Bert Bettina 
Published: April 2023

ZusammenfassungÜberzählige Versuchstiere lassen sich auch bei bester Versuchsplanung und sorgfältigstem
Zuchtmanagement nicht vermeiden, da bei der Zucht von Versuchstieren regelmäßig Tiere entstehen,
die aufgrund verschiedenster Kriterien im geplanten Tierversuch, für den sie ursprünglich gezüchtet
wurden, nicht eingesetzt werden können. Insbesondere bei genetisch veränderten Tieren scheidet
eine Vermittlung oder Weiterverwendung für andere Versuchszwecke oder als Futtertier regelmäßig
aus. Viele Einrichtungen können diese überzähligen Tiere aufgrund fehlender Haltungskapazitäten
auch nicht bis an ihr natürliches Lebensende halten. In der Praxis stellt sich daher die ethisch und
rechtlich viel diskutierte Frage, ob überzählige Versuchstiere unter Annahme eines vernünftigen
Grundes nach 1 S. 2 TierSchG getötet werden dürfen. Im Kern geht es dabei um die im Einzelfall
stets vorzunehmende Abwägung des Tierschutzes gem. Art. 20a GG und der Wissenschaftsfreiheit gem.
Art. 5 Abs. 3 GG. Der vorliegende Beitrag möchte insbesondere untersuchen, ob eine Verfütterung
von überzähligen Versuchstieren und die Unmöglichkeit einer artgerechten Haltung unter Einbeziehung
aktueller Rechtsprechung für sich genommen ausreichen können, um eine Tötung von überzähligen
Versuchstieren aus vernünftigem Grund zu rechtfertigen.
Existence proof of librational invariant tori in an averaged model of HD60532 planetary system
Authors: Danesi Veronica , Locatelli Ugo , Sansottera Marco 
Published: April 2023

AbstractWe investigate the long-term dynamics of HD60532, an extrasolar system hosting two giant planets orbiting in a 3:1 mean motion resonance. We consider an average approximation at order one in the masses which results (after the reduction in the constants of motion) in a resonant Hamiltonian with two libration angles. In this framework, the usual algorithms constructing the Kolmogorov normal form approach do not easily apply and we need to perform some untrivial preliminary operations, in order to adapt the method to this kind of problems. First, we perform an average over the fast angle of libration which provides an integrable approximation of the Hamiltonian. Then, we introduce action-angle variables that are adapted to such an integrable approximation. This sequence of preliminary operations brings the Hamiltonian in a suitable form to successfully start the Kolmogorov normalization scheme. The convergence of the KAM algorithm is proved by applying a technique based on a computer-assisted proof. This allows us to reconstruct the quasi-periodic motion of the system, with initial conditions that are compatible with the observations.
Alterations to unionid transformation during agricultural and urban contaminants of emerging concern exposures
Authors: Rzodkiewicz Lacey D. , Annis Mandy L. , Woolnough Daelyn A. 
Published: April 2023

AbstractHighly imperiled unionids have a complex life cycle including the metamorphosis of an obligate parasite life stage, larval glochidia, to the juvenile stage. Despite the known vulnerabilities of both glochidia and juveniles to pollutants, little is known on how metamorphosis success may be affected by chemical stress. Disruption of the transformation process in which glochidia encyst on the gills of a host fish, could lead to lowered recruitment and population declines. Transformation rates of Lampsilis cardium on host fish Micropterus salmoides were empirically derived from experimental exposures to low, medium, or high concentrations of an agricultural or urban mixture of contaminants of emerging concern (CECs) over two exposure durations. Transformation was characterized by: (1) a zero-inflated Poisson general linear mixed effects model to compare difference in transformation between exposure durations and (2) time response curves to describe the transformation curve using long-term exposure data. Lampsilis cardium transformation was similar between exposure durations. When compared to controls, CEC stress significantly reduced juvenile production (p « 0.05) except for the agricultural medium treatment and tended to increased encapsulation duration which while statistically insignificant (p = 0.16) may have ecological relevancy. Combining the empirically derived reduction of transformation rates with parameters values from the literature, a Lefkovich stage-based population model predicted strong declines in population size of L. cardium for all treatments if these results hold in nature. Management focus on urban CECs may lead to best conservation efforts though agricultural CECs may also have a concentration dependent impact on transformation and therefore overall recruitment and conservation success.
The urban population agglomeration capacity and its impact on economic efficiency in the Yangtze River Delta Urban Agglomeration
Authors: Lin Jinping , Yang Shan , Liu Yanghui , Zhu Yiheng , Cai Anning 
Published: April 2023

AbstractThis paper constructs and elaborates a theoretical model of urban economic efficiency (UEE) from the perspective of urban scaling law. A framework of urban economic analysis is established with urban population agglomeration capacity (UPAC) as the explanatory factor. Taking the Yangtze River Delta Urban Agglomeration (YRDUA) as a case study, explore the influence of UPAC on UEE. The results show that the gap between the UEE in the YRDUA gradually decreases, the spatial agglomeration characteristic weakens, and the UEE among cities leads to a balanced tendency. However, the spatial agglomeration pattern of UPAC becomes more and more significant. (Mega/super) large cities are mostly advanced types, while small cities are lagging types. The influence of UPAC on UEE gradually decreases and diverges from significant positive influence to insignificant influence in advanced cities and significant positive influence in lagging cities. The framework of UEE research provides a more objective way to understand and compare the economic performance of cities of different scales. The empirical study findings provide a basis for decision-making on developing different types of cities.
Information and Explanatory Goodness
Authors: Glass David H. 
Published: April 2023

Abstract
I propose a qualitative Bayesian account of explanatory goodness that is analogous to the Bayesian account of incremental confirmation. This is achieved by means of a complexity criterion according to which an explanation h is good if the reduction in the complexity of the explanandum e brought about by h (the explanatory gain) is greater than the additional complexity introduced by h in the context of e (the explanatory cost). To illustrate the account, I apply it in the context of ad hoc hypotheses.
Sensitivity Analysis of a Physically Based Model to Assess Rainfall-Triggered Shallow Landslides
Authors: Montoya-Araque Exneyder A. , Montoya-Noguera Silvana 
Published: April 2023

AbstractRainfall-triggered shallow landslides are one of the most frequent geomorphological processes in tropical mountainous terrains, and they deserve special attention due to their potential negative consequences in society. Such processes involve several variables including those regarding precipitation, terrain morphology, and hydraulic and shear strength parameters of saturated and unsaturated soils. A spatially distributed and physically-based model for transient rainfall infiltration and grid-based regional slope stability analysis (TRIGRS), was implemented. It was used to analyze the influence of the mentioned variables on the triggering of shallow landslides by rainfall. A robust sensitivity analysis was carried out to quantify the influence of parameter variation on the change of the factor of safety ($$\Delta f_\textrm{s}$$

Δ

f
s

) for shallow landslides, including a one-parameter-at-a-time analysis of a unique cell representing the simplest model space. Four combinations of saturated/unsaturated models and finite/infinite infiltration models were analyzed. The interaction among the hydraulic parameters was analyzed through small-multiple plots to observe their influence on $$\Delta f_\textrm{s}$$

Δ

f
s

. It was found that $$\Delta f_\textrm{s}$$

Δ

f
s

is most sensitive to variation in the maximum depth at which the landslide can be triggered, the slope angle, the cohesion, and the friction angle. In addition, it was found that the parameters of the soil–water characteristic curve for unsaturated soils have little influence on $$\Delta f_\textrm{s}$$

Δ

f
s

. Finally, the interactions among the remaining parameters determine the impact of each one of these on $$\Delta f_\textrm{s}$$

Δ

f
s

. Thus, the results showed that when the baseline set of parameters is changed, the influence of each parameter is modified.
Conception and Development of the Warmth/Affection Coding System (WACS): A Novel Hybrid Behavioral Observational Tool for Assessing Parent-to-Child Warmth
Authors: Prasad Ashneeta H. , Keevers Yvette , Kaouar Silvana , Kimonis Eva R. 
Published: April 2023

AbstractA vast body of research and theory underscores the importance of parental warmth/affection (hereby ‘warmth’ and ‘warmth/affection’ are used interchangeably) as a distinct relational process that is fundamental to core developmental processes including parent-child attachment, socialization, emotion recognition and responsivity, and empathic development. The increasing focus on parental warmth as a viable transdiagnostic and specific treatment target for Callous-Unemotional (CU) traits highlights the critical need for a reliable and valid tool for measuring this construct within clinical contexts. However, existing assessment methods have limitations in their ecological validity, clinical utility, and the comprehensiveness of their coverage of core warmth subcomponents. In response to this clinical and research need, the observational Warmth/Affection Coding System (WACS) was developed to comprehensively measure parent-to-child warmth/affection. This paper chronicles the conception and development of the WACS, which adopts a hybrid approach of utilizing both microsocial and macro-observational coding methods to capture key verbal and non-verbal subcomponents of warmth that are currently underrepresented or poorly captured by existing assessment tools. Recommendations for implementation and future directions are also discussed.
Children’s Talk About Fathers’ Regret: Making Sense of Fathers’ Violence Against Mothers
Authors: Arnell Linda , Källström Åsa 
Published: April 2023

Abstract
Purpose
The aim of this study is to investigate children’s sense-making about their fathers’ attitudes about using violence against the child’s mother. More specifically, we examine various ways in which the children reflect on whether, and if so how, their father showed regret.

Method
This study used data from interviews with 31 children (14 boys and 17 girls) aged between 10 and 14 years, using a semi-structured interview guide. The children’s narratives were analyzed using discourse analysis.

Results
We found that most of the children in this study positioned their fathers as regretful in relation to two discourses—on violence and on fatherhood—that are prominent in the interviews. Some children, however, positioned their fathers as inconsistent or non-regretful, saying they did not express regret emotionally, did not change their behavior, did not communicate regret, or communicated it in a self-contradictory way. In their narratives the children sometimes used interpretative repertoires—about feelings, actions, and communication—to explain why they thought their father did or did not regret his use of violence.

Conclusion
Positioning one’s father as regretful after having committed IPV can be a way to make the father’s attitudes about the violence understandable, both to the children and to others. Discourses on violence and fatherhood can, however, constrain children’s narratives about their fathers’ violence, which is important to keep in mind when working with children who have been exposed to IPV and making decisions that concern them.