bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunomodulating effects of antitumor drugs Bruton tyrosine kinase inhibitors and the possibility of their use in allergic and infectious diseases
Authors: Torshina Yu. S. , Serebryanaya N. B. , Glazanova T. V. , Mikhalyova M. A. , Voloshin S. V. 
Published: June 2023

Bruton's tyrosine kinase (BTK) inhibitors represent a class of drugs that have demonstrated their efficacy and safety in patients with chronic lymphocytic leukemia and non-Hodgkin's lymphomas who were considered refractory to any previously used type of therapy. BTK plays a key role in all stages of B lymphocyte development, but in recent years, there have been data indicating that BTK is also involved in the activation of myeloid cells.The aim of this study is to analyze and systematize all published materials on the immunomodulatory effects of BTK inhibitors (ibrutinib, acalabrutinib, etc.).A systematic review of the scientific literature was performed using a step-by-step search process in electronic databases (PubMed, Web of Science, ScienceDirect, and Scopus). The following keywords were used in the database search: “CLL”, “BTK”, “ibrutinib”, “COVID-19”, “allergy”, “inflammation.” The search for studies was conducted from the time of the first BTK inhibitor drug (ibrutinib) appearance in 2009 until December 2022.The results of the study on the influence of BTK inhibitors on the functional state of B and T lymphocytes, neutrophils, and monocytes/macrophages are presented. The immunomodulatory effects of ibrutinib on adaptive and innate immune system cells, including CD4+ and CD8+T lymphocytes and NK cells, are described. Since BTK inhibitors alter the functional activity of phagocytic cells and the ratio of T cell populations, there is a suggestion about the possibility of using these drugs for the treatment of other nosological forms, not only B cell malignancies, which is currently being studied in clinical trials. Data on the use of BTK inhibitors to combat hyperacute inflammation and to suppress allergic reactions, including anaphylaxis, are summarized. In addition, the expediency of short-term use of BTK inhibitors to reduce the risk of side effects during oral immunotherapy and for desensitization to drugs is discussed.The presented data indicate that BTK inhibitors are promising drugs with immunomodulatory effects. However, BTK inhibitors need to increase selectivity to reduce off-target effects on other kinases.
Innate immune factor gene expression profiles in patients with atopic dermatitis
Authors: Bystritskaia E. P. , Murashkin N. N. , Olisova O. Yu. , Materikin A. I. , Potapova M. B. , Vinnitskaya A. B. , Upatova A. G. 
Published: June 2023

Atopic dermatitis is a multifactorial genetically determined inflammatory skin disease characterized by itching, chronically relapsing dermatitis, age-related features of localization and morphology of lesions. The pathogenesis of atopic dermatitis is complex and includes epigenetic alterations, involved in the genomic adaptation, immune response reactions and dysfunction of the epithelial barrier that together trigger the development of atopic dermatitis. The aim of this study is to detect the expression level for IL4, IL13, IL33, TLR2, TLR9 genes in the biological materials of atopic patients.The targeted genes for further expression evaluation were selected according to our previous findings on genome-wide methylation study. We detected the cascades with the differentially methylated genes that are most likely to take place in atopic dermatitis. Thus, we investigated expression levels for the IL4, IL13, IL33, TLR2, TLR9 genes in the skin, peripheral blood mononuclear cells and whole blood cells using RT-PCR on 55 pediatric patients and 26 healthy volunteers, and on 50 adult patients. Statistical analysis was performed with the use of Kruskal-Wallis H test and Mann-Whitney U test. Targeted expression analysis revealed that in the skin samples the expression of TLR9 and IL4 was 12 times significantly lower (p < 0.0001, p < 0.0005) in the lesional skin; and there was a 6-fold decrease in case of TLR2 (p < 0.01). The results for blood mononuclear cells differed and expression levels for most of the assessed targets were significantly higher before treatment. We have also found out that those differences were strongly pronounced especially in an elder age group (12-18 y.o.). Studying the IL33 gene expression in the whole blood samples of adults revealed that its level was significantly higher in case of patients with moderate form of AD. Besides, we concluded that locally in the affected skin inflammatory immune response may dominate; in the mononuclear cells Th2 immune response apparently takes place. New insights on immunological markers and links among them may shed a light on atopic dermatitis pathogenic mechanisms. The detected molecules could play role as potential therapeutic targets and form a management approach for patients with atopic dermatitis.
Virtuelle Methoden in der Produktionstechnik
Authors: Jaensch Florian , Klingel Lars , Fur Shan , Verl Alexander 
Published: June 2023

Neue Entwicklungen und innovative Lösungen in der Produktionstechnik werden größtenteils in Form von Software realisiert. Um die damit einhergehende Komplexität zu beherrschen, werden simulationsbasierte Methoden eingesetzt. Eine etablierte Methode, um Steuerungssoftware realitätsnah zu testen und abzusichern ist die Virtuelle Inbetiebnahme. Die Anwendung virtueller Methoden endet heutzutage aber mit dem Produktionsstart. In diesem Artikel werden die Potenziale der Virtuellen Inbetriebnahme als Bindeglied zwischen der virtuellen und realen Produktion aufgezeigt und die notwendigen Voraussetzungen werden diskutiert.
Erste Schritte in ein Industrial Metaverse für Prozessanlagen
Authors: Labisch Daniel , Hutter Andreas , MacWilliams Asa , Kokkelink Bernd 
Published: June 2023

Auch wenn die Möglichkeiten im Industrial Metaverse noch nach Zukunftsmusik klingen, beeindrucken die heute schon realisierbaren Lösungen. Dieser Beitrag fokussiert sich auf Anwendungen und Use Cases in Augmented Reality (AR), einem wesentlichen Baustein des Industrial Metaverse. Dazu werden in AR verfügbare Informationen vorgestellt, die in mehreren Use Cases genutzt werden. Zwei beispielhafte Proof-of-Concepts veranschaulichen was bereits heute möglich ist.
Is PowerScope2 an effective Class II corrector ? A prospective cephalometric study
Authors: Jain Dhruv , Datana Sanjeev , Chopra Sukhbir Singh 
Published: June 2023

The study was carried out to evaluate skeletal, dental and soft tissue effects produced by PowerScope 2 appliance following the correction of skeletal Class II malocclusion.A total of 10 patients (3 males and 7 females with mean age of 14.40 ± 0.70 yrs) diagnosed with skeletal Class II malocclusion and indicated for fixed functional appliance were treated using Power Scope2 appliance. Paired t-test was used to assess skeletal, dental and soft tissue changes evaluated on lateral cephalograms taken at pre-functional (T1) and post-functional (T2) stages. Maxillomandibular sagittal relation was markedly improved with a significant gain in the length of the mandible along with a restraining effect on the maxillary dentition. The improvement in molar relation was mainly contributed by dentoalveolar effects (72.3 %) and secondarily by skeletal effects (27.7 %) while the reduction in overjet was contributed by 22.4% skeletal and 77.6% dental effects. Vertical changes were non-significant. Following PowerScope 2 therapy there was an overall improvement in facial esthetics.Power Scope2 serves as an effective skeletal Class II corrector with primarily dentoalveolar and secondary skeletal effects.
Evaluating the thermal efficiency and net power output of ORC for three wet fluids
Authors: Kezrane Cheikh , Habib Sadam Houcine , Laouid Youcef Abdellah Ayoub , Lasbet Yahia , Pesyridis Apostolos 
Published: June 2023

Low-grade heat can be successfully recovered from waste energy sources for power production by an organic Rankine cycle (ORC). In this work, reheat ORC has been studied with three different wet organic fluids. The performance of R1270, R152a and Cyclopropane has been modelled in an ORC operated by a source of heat of 413.15K. The reheat ORC model contains economizer, evaporator, superheater, reheater, two turbine, pump and condensers. With variable turbine inlet temperature and reheat pressure, the net power output and thermal efficiency have been estimated. The results show that there exists an optimum temperature at the turbine inlet maximizing . The increase of reheat pressure gives only a marginal growth in the cycle efficiency, but it rises the with about 16.88 %, 16.26 % and 13.23 % for R1270, R152a and cyclopropane respectively.
Financial Access and MSMEs Performance during Pandemic COVID-19: The Moderating Role of Digitization
Authors: Dewi Nurma Gupita , Ridhasyah Rizki , Wibawa Tio Anta 
Published: June 2023

The Micro Small and Medium Enterprises (MSMEs) sector is critical pillars of the Indonesian economy. The COVID-19 pandemic has had a negative impact on MSMEs. The existence of activity violation policies, namely lockdown and social distancing, needs to be anticipated by MSME actors because it has changed consumer behavior and business competition. Digital transformation is a solution for MSMEs to survive the COVID-19 pandemic. The objective of this study is to investigate the impact of access to finance on MSME performance moderated by digitalization. This study utilized 83 MSMEs as a sample. Data was collected by distributing questionnaires to MSME owners who were selected as research samples. Data analysis was performed using the Moderated Regression Analysis (MRA) method. The results of the study indicated that digitization significantly strengthens the relationship between financial access and MSME performance. For MSME actors, digitization will also make it simpler to introduce products, boost turnover, and assist with recording and producing financial reports.
KPI ON THE WAY OF FORMING AN ENERGY-EFFICIENT SOCIETY. 25 YEARS OF EXPERIENCE
Authors: Denysiuk Serhii , Shovkaliuk Maryna 
Published: June 2023

Given the energy dependence of our state, the rational use of resource potential is a strategic direction for the development of the Ukrainian economy. Increasing energy efficiency is an important condition for the successful implementation of climate policy. The modern market of energy efficient services requires a significant number of trained specialists in the field of energy audit, energy management, energy consumption management, energy efficiency certification, heat and electrical engineering, process automation in industry and housing and communal services. In 2021, the Educational and Scientific Institute of Energy Saving and Energy Management (NN IEE) Igor Sikorsky Kyiv Polytechnic Institute Igor Sikorsky, since 1997 heir to the Faculty of Mining (GF), the Faculty of Mining Electromechanics and Automation (FGEMA), the Faculty of Mining Technology (GTF), celebrated 75 years since its founding. And already in the current 2022, we have another significant and pleasant event – 25 years of the creation of the specialty «Energy Management». By a joint order of the Ministry of Education and the State Committee for Energy Saving of Ukraine (No. 137/45 dated May 07, 1997), IEE was defined as the basis for training specialists in this specialty. The article reflects the main stages of the formation and development of the institute, scientific achievements, the contribution of the team to the training and advanced training of personnel and educational activities in the field of energy efficiency. NN IEE, as the founder of the «Energy Management» specialty, has gone through a long path of formation and development. ІЕЕ prepares students according to the educational programs «Energy Management and Energy-Efficient Technologies», «Systems of Supplying Consumers with Electric Energy».
ANALYSIS OF THE CONTROL SYSTEM OF A WIND PLANT CONNECTED TO THE AC NETWORK
Authors: Nerubatskyi Volodymyr , Hordiienko Denys 
Published: June 2023

The dynamics of the development of alternative power sources over the past few decades are presented, which gives reason to talk about the trends in the further development of wind energy. An analysis of the structures and technical characteristics of wind generators is provided, namely, types of electric motors, power circuits of semiconductor converters that provide the generation of electrical energy to the general industrial electrical network. The issue of the possibility of operation of wind generators in wide wind ranges, the issue of emission of reactive power and higher harmonics of currents to the general industrial electrical network, as well as the issue of the efficiency of various structures of wind generators are considered. A wind turbine control system with an asynchronous generator is proposed. A study of transient control processes and energy compatibility of a full energy conversion wind turbine with a power supply network by simulation computer modeling in the Matlab / Simulink software environment is given. The obtained result indicates the possibility of operation of an asynchronous generator with a short-circuited rotor as part of a wind turbine, which makes it possible to provide power to the alternating current network at low wind speeds.
STATE MARKET SUPERVISION OF THE QUALITY OF MOTOR FUELS, PROBLEMS AND WAYS TO SOLVE THEM
Authors: Sibilieva Olena , Shkilniuk Iryna , Dokshyna Dokshyna 
Published: June 2023

The quality of motor fuels during consumption is a guarantee of the reliability of the operation of vehicles, the efficiency of the operation of machines, mechanisms and other equipment. Considering the toxic, carcinogenic, fire, and explosive properties, motor fuels belong to extremely dangerous substances, non-food products with an increased degree of risk for all categories of consumers, regardless of the way and method of their use. In particular, waste gases of toxic substances during internal combustion pose a danger to the environment, human life and health.
Proper control over the quality of motor fuels, making strategic management decisions for their safe circulation is the main component for the further development of the oil industry in Ukraine, ensuring the needs and satisfaction of consumers, the demand for petroleum products at the international level, in particular, the development of free trade.
The article provides standards and requirements for the quality of motor fuels, reflects the results of examinations (tests) of automobile gasoline and diesel samples conducted in 2021. Possible causes of low-quality fuel are given and measures to overcome them are proposed. 196 samples of automobile gasoline and 111 samples of diesel fuel were selected for examinations (tests). According to the results of examinations (tests), non-compliance with the requirements of the Technical Regulation was found in 24.9% of automobile gasoline samples and in 19.8% of diesel fuel samples. One of the reasons for low-quality fuel is uncontrolled use of additives (dopes) by economic entities, improper internal control of fuel during mixing, including during storage, transportation and introduction of non-food products into circulation.
It is also noted that one of the prerequisites for the creation of high-quality fuel on the market of Ukraine is the need to carry out measures to harmonize the current legislative acts, introduce changes or develop new normative documents in the field of quality and control of petroleum products, update state standards, conduct scientific research, and implementation of the requirements of the European Union into the current acts of Ukraine. In particular, an important aspect is the development of a chain of monitoring and control at various stages of the production cycle, processing (mixing), determining the expediency of using additives, dopes (dyes) to products, taking into account the physical and chemical properties of fuel, dynamic and mechanical indicators of vehicle engines.
MARINE FUEL WITH LOW SULFUR CONTENT, PRODUCTION PROSPECTS IN UKRAINE
Authors: Chernyavsky A.V. , Grigorov Andrey 
Published: June 2023

The article examines the main world trends in the field of fuel use for shipping. The need to replace the F-5 and F-12 fleet fuel oils, which are widely used by the merchant fleet of Ukraine today, with new, low-sulfur fuel, such as marine gasoil (MGO) or low sulfur marine gasoil (LS-MGO), is substantiated. The main problems that, taking into account the role of cargo transportation by sea in Ukraine, may arise during the transition of shipping to new types of fuel are characterized. At the same time, directions for solving these problems without a significant impact on the cost of freight transportation are proposed, which consist in the selection of raw materials, preliminary processing of raw materials, the use of the latest technologies and compounding of finished goods.
In practice, in the production of marine fuel with low sulfur content, the most effective is the combination of several directions into a single technological chain: "selection of raw materials - the latest technologies" or "selection of raw materials - the latest technologies - compounding". Considering this, today, one of the most promising technological processes for the production of motor fuels, in particular marine fuels, in Ukraine can be considered catalytic pyrolysis on zeolites of secondary polymer raw materials.
THE LIMIT DISTANCES OF CONNECTION OF OBJECTS AND CONSUMERS TO ENERGY SOURCES BY DIFFERENT POWER SUPPLY SYSTEMS
Authors: Khotian Artem , Rozen Victor 
Published: June 2023

This article is devoted to the development of a methodology for selecting the optimal variant of the power supply system for a remote local facility from the centralized integrated power system. The article proposes and formulates a definition of the term local power facility.
The main factors influencing the choice of a power supply system for a remote facility from a centralized power supply system are analyzed, including: the remoteness of the consumer from the centralized power grid, load power, the nature of the loads, its natural and climatic, and socio-economic conditions of location.
A classification of power supply systems of local energy facilities has been developed according to such categorical features as: sources of electricity supply, nature of power supply operation, location of the power supply, nature of consumer connection to the power supply, and method of electricity distribution.
The article develops the equations of the boundary radii of connection of electrical installations to power sources in the case of centralized power supply from the integrated power system and centralized power supply from the own power plant within the local power facility. Schematic diagrams of power supply of local energy facilities with a detailed description of their elements are constructed.
The advantages and disadvantages, as well as opportunities and threats to the development of power supply of local facilities as part of microgrids are presented. The advantages of centralized power supply include the low cost of energy and its much higher quality compared to the energy received from own power plants. The disadvantages of decentralized electricity supply include the high cost of investment in the equipment of own solar, wind or fuel power plants, usually of high capacity and staffed by highly qualified specialists, as well as problems with energy storage and the need to purchase fuel, its delivery and storage in large volumes.
The article provides strategic directions necessary for the development and dissemination of energy innovations in Ukraine in the long term.
COMPARATIVE ANALYSIS OF FOREIGN AND DOMESTIC ENERGY EFFICIENCY INDICATORS AND THEIR CALCULATION
Authors: Viktor Rozen Viktor Rozen , Dokshyna Sofiia 
Published: June 2023

Climate change, the level of environmental pollution, the assessment of the exhaustion of traditional raw materials for energy generation, the awareness of the fact that the negative impact on the environment is caused by anthropogenic activities, the world economic crises and the search for ensuring a happy and safe life for future generations became the driving force for the development of energy efficiency. But in order to understand the individual directions of tasks in increasing the level of energy efficiency, it is worth defining approaches to its assessment. It is interesting that this field includes not only the concept of "energy", but also has a connection and to some extent limitations with the fields of economics, ecology and law.
This paper analyzes the concepts and approaches used in assessing the level of energy efficiency internationally and in the middle of the country. The results of the analysis showed that in global practice, energy efficiency assessment based on final consumption is used in four spheres of activity: production, transport, services and households. In each of the subsectors, the energy consumption indicator is evaluated in comparison with the previous year. And the index at the sector level is the average weighted sum of the indicators of its subsectors. To obtain better results, various types of adjustments are used. Climate corrections and purchasing power parity adjustments are one of them. To increase the level of energy efficiency within the country, it is possible to apply the listed practices at the regional level.
THE STUDY OF HEAT TRANSFER INTENSITY AND AERODYNAMIC DRAG INSIDE A FLAT PIPE
Authors: Kulynych Vladislav , Rogachev Valerij , Terekh Alexander , Terekh Alexander 
Published: June 2023

It is know that a heat exchange tube with a flat-oval profile has excellent thermal and aerodynamic characteristics in contrast to a round tube. Thus, with the same planes, a flat tube has a significant increase in thermal and aerodynamic efficiency compared to a round tube, which is widely used in industry. However, at present, there are a limited number of publications on the study of heat transfer and aerodynamics inside a flat pipe.
In this paper, we present the methodology and results of the study of heat transfer and aerodynamic drag in a pipe, and describe the experimental stand for such studies.
The experiments performed in a flowing wind tunnel with an internal diameter of 36 mm, operating in an open-loop circuit. The working medium is air drawn from the laboratory room. The prototype was a steel pipe with a flat-oval profile, 320 mm long, 30x15 mm cross section, and 2 mm wall thickness.
The created experimental stand allows us to study the heat transfer and aerodynamic drag of a flat pipe under the boundary condition q=const. An electric heater ensured this condition, which is a nichrome wire with a diameter of 0.6 mm wound along the entire length of the pipe and insulated from the external environment.
The experiments were carried out in the range of Reynolds numbers (10.5 - 55.0) 103 and dissipated powers (50 - 150) W. The average air temperature in the pipe was set in the range (20 - 55) 0C, and the average temperature of the pipe wall was set in the range (24 - 140) 0C in accordance with the electric power supplied to the heater.
Empirical correlations proposed for determining the intensity of heat transfer and aerodynamic drag inside a flat pipe. The data had compared with a round tube. The results had analyzed, and it had shown for the first time that the intensity of heat transfer and aerodynamic drag in a flat-oval pipe is 1.1 to 1.2 times and 1.4 to 1.7 times higher, respectively.