bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microsupercapacitors Working at 250 °C
Authors: Mishukova Viktoriia , Su Yingchun , Chen Shiqian , Boulanger Nicolas , Xu Bo , Thangavelu Hari Hara Sudhan , Sun Jinhua , Xia Wei , Talyzin Alexandr , Li Jiantong 
Published: July 2023

AbstractThe raised demand for portable electronics in high‐temperature environments (>150 °C) stimulates the search for solutions to release the temperature constraints of power supply. All‐solid‐state microsupercapacitors (MSCs) are envisioned as promising on‐chip power supply components, but at present, nearly none of them can work at temperature over 200 °C, mainly restricted by the electrolytes which possess either low thermal stability or incompatible fabrication process with on‐chip integration. In this work, we have developed a novel process to fabricate highly thermally stable ionic liquid/ceramic composite electrolytes for on‐chip integrated MSCs. Remarkably, the electrolytes enable MSCs with graphene‐based electrodes to operate at temperatures as high as 250 °C with a high areal capacitance (~72 mF cm−2 at 5 mV s−1) and good cycling stability (70 % capacitance retention after 1000 cycles at 1.4 mA cm−2).
Highly efficient expression and secretion of human lysozyme using multiple strategies in Pichia pastoris
Authors: Wang Yasen , Wang Buqing , Gao Yahui , Nakanishi Hideki , Gao Xiao‐Dong , Li Zijie 
Published: July 2023

AbstractBackgroundHuman lysozyme (hLYZ), an emerging antibacterial agent, has extensive application in the food and pharmaceutical industries. However, the source of hLYZ is particularly limited.ResultsTo achieve highly efficient expression and secretion of hLYZ in Pichia pastoris, multiple strategies including G418 sulfate screening, signal sequence optimization, vacuolar sorting receptor VPS10 disruption, and chaperones/transcription factors co‐expression were applied. The maximal enzyme activity of extracellular hLYZ in a shaking flask was 81,600 ± 5230 U mL−1, which was about five times of original strain. To further reduce the cost, the optimal medium RDMY was developed and the highest hLYZ activity reached 352,000 ± 16,696.5 U mL−1 in a 5 L fermenter.ConclusionThis research provides a very useful and cost‐effective approach for the hLYZ production in P. pastoris and can also be applied to the production of other recombinant proteins.
Examining the effects of a modified SART when measuring mind‐wandering
Authors: liu Yuqing , Dong Qin , Yu ChengHao , Jin YuTong , Fang ChenYuan , Hu Yu , Zhou Qiang 
Published: July 2023

AbstractObjectiveMind‐wandering (MW) is defined as a shift of attention from external tasks toward internal thoughts and is popularly measured by the sustained attention to response task (SART). SART is able to capture MW, but cannot track the dynamics of mind‐wandering over time well. We thus attempted to modify the sustained attention to response task paradigm (mSART) to capture the participant's mind‐wandering state over time and quantify the degree of mind‐wandering using the current behavioral data.Methods179 participants from Wenzhou Medical University were recruited to participate in this experiment. The main changes to the experiment included (1) manipulating different no‐go stimuli frequencies to control the difficulty of the task and setting 9 modes; (2) extending the experiment time to 30 min; (3) allowing participants to correct errors by pressing the b key. Error rate, Mean RTs, RT CV, and d' were used to reflect MW. Analysis of covariance (ANCOVA) was performed.ResultsANOVA was used to explore Mean RTs, RT CV and d’ for participants with different levels of mind‐wandering and significant differences were found (Mean RTs:Welch's F (2, 8606.04) = 579.00, p < .001, ηp2 = 0.03; RT CV:Welch's F (2, 198.11) = 69.93, p < .001, ηp2 = 0.18; d':F (2, 176) = 19.88, p < .001, ηp2 = 0.18). The 30‐min experiment was divided into six time windows, and mind‐wandering deepens over time.ConclusionsThe mSART paradigm could quantify the extent of MW based on changes in the frequency at which the no‐go stimuli were presented and also revealed that the recommended length of the experiment was about 20 min.
Nut consumption and urogenital and genital, gastrointestinal and women‐related cancers: Assessment and review
Authors: Mohamadi Maryam , Dousdampanis Periklis , Ahmadi Zahra , Pourmasumi Soheila , Naderi Monavare , Zainodini Nahid , Nazari Alireza 
Published: July 2023

AbstractThe prevalence of cancer, especially in industrial countries, is a major problem for health and treatment systems. Cancer can affect the quality of life of all family members and has many negative effects on the community. Despite many advances in cancer treatment, this disease is still a major worldwide problem. There is strong evidence that dietary habits are effective in protecting against cancer and even helping in the disease treatment progress. Nuts with various biologically‐active compounds, such as vitamins, phytosterols, isoflavones, flavonoids, and polyphenols have been reported to possess anticarcinogenic properties. Accordingly, this review provides an insight into the association between nut consumption and the prevention of some cancers. We considered the cancers related to the urogenital and genital tract, gastrointestinal tract, as well as women‐related cancers. Both cell culture examinations and experimental animal studies alongside observational epidemiological studies demonstrated that regular consumption of a nut‐enriched diet is able to reduce the risk of these cancers.
Risk of decreased ovarian reserve in women with HPV infection and cervical lesions
Authors: Fakor Fereshteh , Gashti Nasrin G. , Fallah Amirhossein H. , Kabodmehri Roya , Rafiei Sorouri Zahra , Hasanzadi Aida , Pourhabibi Zahra 
Published: July 2023

AbstractBackgroundHuman papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reserve.MethodsThis case‐control study was performed on 219 women aged 25–35 years who were referred to the gynecologic oncology clinic during 2019–2020. The positive or negative HPV infection was confirmed by cervical biopsy and polymerase chain reaction (PCR) test. Cervical lesions or abnormalities in the cervix were assessed by colposcopy and histopathological analysis. Serum anti‐Mullerian hormone (AMH) levels were measured for all participants to assess ovarian reserve.ResultsThe results of this study showed that in patients who were HPV positive, decreased ovarian reserve was more common than in the HPV negative group (p = 0.0001). Also, there was a significant difference between Cervical intraepithelial neoplasia (CIN) I and CIN III sub‐groups in AMH level (p = 0.0001).ConclusionsTraces of HPV have been observed in various aspects of infertility, but no study has been performed on its association with ovarian reserve. According to the results of this study, decreased ovarian reserve was more common in patients who were HPV positive.
Shallow and local or deep and regional? Inferring source groundwater characteristics across mainstem riverbank discharge faces
Authors: Haynes Adam B. , Briggs Martin A. , Moore Eric , Jackson Kevin , Knighton James , Rey David M. , Helton Ashley M. 
Published: July 2023

AbstractRiverbank groundwater discharge faces are spatially extensive areas of preferential seepage that are exposed to air at low river flow. Some conceptual hydrologic models indicate discharge faces represent the spatial convergence of highly variable age and length groundwater flowpaths, while others indicate greater consistency in source groundwater characteristics. Our detailed field investigation of preferential discharge points nested across mainstem riverbank discharge faces was accomplished by: (1) leveraging new temperature‐based recursive estimation (extended Kalman Filter) modelling methodology to evaluate seasonal, diurnal, and event‐driven groundwater flux patterns, (2) developing a multi‐parameter toolkit based on readily measured attributes to classify the general source groundwater flowpath depth and flowpath length scale, and, (3) assessing whether preferential flow points across discharge faces tend to represent common or convergent groundwater sources. Five major groundwater discharge faces were mapped along the Farmington River, CT, United States using thermal infrared imagery. We then installed vertical temperature profilers directly into 39 preferential discharge points for 4.5 months to track vertical discharge flux patterns. Monthly water chemistry was also collected at the discharge points along with one spatial synoptic of stable isotopes of water and dissolved radon gas. We found pervasive evidence of shallow groundwater sources at the upstream discharge faces along a wide valley section with deep bedrock, as primarily evidenced by pronounced diurnal discharge flux patterns. Discharge flux seasonal trends and bank storage transitions during large river flow events provided further indication of shallow, local sources. In contrast, downstream discharge faces associated with near surface cross cutting bedrock exhibited deep and regional source flowpath characteristics such as more stable discharge patterns and temperatures. However, many neighbouring points across discharge faces had similar discharge flux patterns that differed in chloride and radon concentrations, indicating the additional effects of localized flowpath heterogeneity overprinting on larger scale flowpath characteristics.
Cross‐talk of pyroptosis‐based subtypes, the development of a risk classifier and immune responses in cervical cancer
Authors: Gu Jiamin , Ding Bo 
Published: July 2023

AbstractBackgroundCervical cancer (CC) is one of the most common gynecology malignancies and has a dismal survival outcome. The prognostic value of pyroptosis and its role in the regulation of immune metabolism in CC remain unclear.MethodsTwo independent CC cohorts collected from public databases were integrated for unsupervised cluster analysis. All CC cases were assigned to different subsets based on the pyroptosis‐related genes (PRGs). The differentially expressed genes (DEGs) between different subclusters were included in stepwise Cox regression for the risk classifier establishment. Next, single‐cell sequencing analysis was conducted to explore the cellular location of each model gene. The CIBERSORT algorithm was applied to estimate immunocytes infiltration. Finally, a series of functional experiments were performed to detect the role of CDH3 in CC.ResultsBased on the 52 PRGs, the combined CC cohort was clustered into two subsets (C1 (n = 259) and C2 (n = 242)). Survival and Cox regression methods were used to create a pyroptosis‐based risk classifier including four PRGs (PEG3, FSCN1, CDH3 and SLC2A1). For the immune environment in CC, the high‐risk group had a lower infiltration level of B cells, memory‐activated CD4 T cells and CD8 T cells and a higher infiltration abundance of neutrophils. The expression pattern of model genes was confirmed in CC cell lines by PCR assay. Furthermore, we observed that knockdown of CDH3 could suppress CC cell proliferation.ConclusionOur project could offer promising reference for prognosis assessment, immune metabolism prediction and clinical decision‐making of patients with CC.
Understanding the Black male experience: Recommendations for clinical, community, and school settings
Authors: Burt Isaac , Hines Erik M. , Moore James L. 
Published: July 2023

AbstractThe characterizations of Blackness and maleness are stark and pervasive throughout the theoretical and scientific literature. Too often, Black males occupy a vicarious and distinctive position in American society. The depictions of Black males are rarely casted in a positive manner. Instead, an overpowering image of incompetence, unintelligence, complacency, and propensity to result to violence consumes the livelihood of Black males in the United States. Thus, despite these perceptions, they have been resilient, successful, and stubbornly resistant to negative typecasts. Moreover, there has to be a better awareness and understanding of the educational challenges and psychological and social struggles that Black males endure as “they define who they are, build and maintain relationships, cope with racism, and search for strengths in the African American way of being”. Further, more research is needed to better support Black males in clinical, community, and school settings. This special issue on the Black male experience is a step in this direction. To that end, the Journal of Multicultural Counseling and Development (JMCD) presents five theoretical, qualitative, and quantitative articles focusing specifically on the Black male experiences in both clinical and educational contexts. Each article, in its own way, amplifies the importance of culturally responsive approaches.
Assessment of projected climate change impact on agro‐climatic indicators in Poland
Authors: Marcinkowski Paweł , Piniewski Mikołaj , Jefimow Maciej 
Published: July 2023

AbstractThis study presents a long‐term assessment of the impact of projected climate change on selected agro‐climatic indicators in Poland. The analysis was based on an ensemble of six bias‐corrected EURO‐CORDEX projections covering the period from 2006 to 2100 under Representative Concentration Pathways: RCP4.5 and 8.5, and partly on simulations of an agro‐hydrological Soil and Water Assessment Tool model. The indicators included growing season (length, beginning, and ending date), growing degree days, frost days, accumulated frost, and planting and harvest timing. The study focused on four major crops cultivated in Poland, namely spring barley, rapeseed, maize silage, and potato. The analysis revealed a significant future increase in precipitation and mean temperature in Poland reaching +10.3% and 3.4°C by the end of century, respectively. Warmer conditions will significantly accelerate the beginning of the growing season (by up to 24 days) and delay its ending (by up to 18 days), consequently significantly extending its length throughout the country (by up to 42 days). A decrease is projected in potential soil moisture deficit by up to 26 mm by the end of century in the high‐end emission scenario. A significant advancement (by up to 30 days) in planting timing is projected for the future for all crops under consideration. A significant increase in growing degree days (by up to 760°C‐days) will also advance the harvest timing (by up to 54 days). The projected temperature increase over the winter season will result in a significant decrease in frost days (by 56 days) and accumulated frost (by 375°C‐days), which may lead to an increased presence of pests. This study can provide a scientific basis for assessing the future risks to the local agriculture from climate change and will be beneficial in planning adaption and mitigation actions for food security at the national and local scale.
Tribological characteristics evaluation of a helical gear pair based on the tribo‐dynamic model
Authors: Liu Mingyong , Han Xinguang , Yan Chunai , Ouyang Zhouhuan , Qi Dezhong 
Published: July 2023

AbstractIn this paper, a tribo‐dynamic model of a helical gear is established. For the lubrication sub‐model, a finite line thermal elastohydrodynamic lubrication model of helical gear is adopted. The lateral vibration, axial vibration of gear and torsional vibration of the gear shaft are considered in the dynamic sub‐model. Results show that the tribological parameters of helical gear under the tribo‐dynamic model deviate significantly from that of the quasi‐static model, especially in the engaging‐in region of tooth pair. The friction excitation mainly affects the vibration along the off‐line‐of‐action direction of the gears. The influence of operating conditions on the tribological and dynamic properties of a helical gear pair is significant, especially in the case related to the characteristic frequency of gears.
MXene‐Based Soft Actuators with Multiresponse and Diverse Applications by a Simple Method
Authors: Xu Mengjie , Li Lin , Zhang Wei , Ren Zhen , Liu Jinquan , Qiu Changwen , Chang Longfei , Hu Ying , Wu Yucheng 
Published: July 2023

AbstractSmart actuators that can convert external energy stimuli into mechanical energy output have great potential in industrial, biomedical, and military applications. However, the existed disadvantage such as complex fabrication process, single stimulus source, and the requirement of artificial energy restrict their further development. Herein, a MXene/polyethylene (PE)‐based soft actuator with multistimulus response and the ability to be driven by natural sunlight and human humidity is proposed through a simple method. Owing to the excellent electrical conductivity, high photothermal conversion capability, and surface hydrophilicity of MXene, the MXene/PE actuator exhibits rapid and large bending deformation in response to external multistimuli such as light, electricity, heat, and humidity. Owing to the simple preparation, and anisotropic, tailorable and programmable properties of the MXene/PE actuator, a soft robot that can crawl directionally under light conditions is constructed. In addition, based on the high sensitivity response of the actuator to light and humidity, smart clothing that can generate reversible bending deformation under natural sunlight as well as sweat conditions is developed. These results provide a new inspiration for the design of high‐performance soft actuators with multistimulus response, and demonstrate the potential applications of the MXene/PE actuators in smart devices, bionic robots, and wearable clothing.
Identification and expression of small multidrug resistance transporters in early‐branching anaerobic fungi
Authors: Seppälä Susanna , Gierke Taylor , Schauer Elizabeth E. , Brown Jennifer L. , O'Malley Michelle A. 
Published: July 2023

AbstractMembrane‐embedded transporters impart essential functions to cells as they mediate sensing and the uptake and extrusion of nutrients, waste products, and effector molecules. Promiscuous multidrug exporters are implicated in resistance to drugs and antibiotics and are highly relevant for microbial engineers who seek to enhance the tolerance of cell factory strains to hydrophobic bioproducts. Here, we report on the identification of small multidrug resistance (SMR) transporters in early‐branching anaerobic fungi (Neocallimastigomycetes). The SMR class of transporters is commonly found in bacteria but has not previously been reported in eukaryotes. In this study, we show that SMR transporters from anaerobic fungi can be produced heterologously in the model yeast Saccharomyces cerevisiae, demonstrating the potential of these proteins as targets for further characterization. The discovery of these novel anaerobic fungal SMR transporters offers a promising path forward to enhance bioproduction from engineered microbial strains.
Research and practice of key technologies for landslide dam development and utilization—A case in Hongshiyan landslide Dam Water Conservancy Project
Authors: Zhang Zongliang , Wu Xueming , Xiao Enshang , He Ning , Cheng Kai , Zhang Ga , Zhou Xingbo , Zhao Chun , Wang Huanling , Du Hongming , Jiang Xiangang 
Published: July 2023

AbstractBased on the emergency rescue, the subsequent disposal, and the development and utilization projects of the Hongshiyan Landside Dam in Ludian, Yunnan, China, research has been conducted on key technical issues facing the development and utilization of landside dams, including the possibilty evaluation of development and utilization, structure analysis of wide gradation material, performance evaluation, investigation and design, dam seepage control, construction technology and equipment, and safe operation assessment. And innovative results has made in all seven aspects mentioned above, writing the history in this field. The achievements were directly applied to the development planning, investigation and design, construction, and operation and maintenance of the Hongshiyan Landside Dam, a comprehensive water conservancy project that integrates flood control, water supply, irrigation, and power generation, with significant comprehensive benefits.
Effective Three‐Step Construction of Betulonic Acid Hybrids with Heterocycle‐Containing Peptidomimetic Fragments
Authors: Murlykina Maryna , Pavlovska Tetiana , Semenenko Oleksandr , Kolomiets Oleksandr , Sanin Edward , Morozova Alisa , Kornet Maryna , Musatov Vladimir , Kulyk Karyna , Mazepa Alexander , Lipson Victoria , Chebanov Valentyn 
Published: July 2023

AbstractSynthesis of hybrid molecules containing a natural betulonic acid core and a peptidomimetic moiety was carried out by a three‐step transformation: e. g. (i) Ugi four‐component reaction involving heterocyclic amines to obtain some new azido‐substituted peptidomimetics; (ii) isolation of the compounds from the natural raw materials and obtaining betulonic acid propargyl esters; (iii) Cu‐catalyzed cycloaddition of peptide‐structured azides to betulonic acid propargyl esters, resulting in the construction of target molecules. The microbiological properties of the hybrid compounds and their precursors were tested against two Gram‐positive and two Gram‐negative bacterial strains.
Two‐ and Three‐Dimensional Strategies for Determining Consecutive Acidity Constants of Ciprofloxacin and Enrofloxacin Using Fluorescent Excitation‐Emission Measurements
Authors: Dinç Erdal , Yazan Zehra , Ertekin Zehra Ceren , Yıldız Ceren 
Published: July 2023

AbstractMultidimensional analysis is getting more popular by the day thanks to technical improvements of analytical instruments and development of chemometric methods. Here, we describe the application of two different chemometric methods to the analysis of three‐dimensional spectrofluorimetric dataset for green determination of dissociation constants of ciprofloxacin and enrofloxacin with minimal use of consumables. Three‐dimensional spectrofluorimetric datasets of both drugs were obtained by recording excitation‐emission matrices of only six sample solutions having different pH values. Parallel factor analysis (PARAFAC) and multivariate curve resolution (MCR) methods with the use of three components were used to decompose three‐dimensional excitation‐emission‐pH arrays. The number of components support the presence of two pKa values. The individual profiles of H2A, HA− and A2− species in excitation, emission and pH modes were obtained by the application of PARAFAC and MCR. The intersection points in the pH modes were used to predict pKa values. pKa1 and pKa2 of ciprofloxacin was reported as 6.35, 9.15 and 6.42, 9.40 by PARAFAC and MCR‐ALS, respectively. For enrofloxacin, consecutive pKa values were predicted as 6.11 and 9.06 by PARAFAC and 6.10 and 9.10 by MCR. A detailed comparison to literature was done for the estimated pKa values.
Water‐Mediated C−H Cyanation of Quinoxalin‐2(1H)‐ones and Quinoxalines Under Visible‐Light Conditions
Authors: Badhani Gaurav , Adimurthy Subbarayappa 
Published: July 2023

AbstractRegioselective cyanation of quinoxalin‐2(1H)‐ones and quinoxalines with acetone cyanohydrin under aqueous aerobic visible‐light conditions at room temperature is described. Acetone cyanohydrin is utilized as a safe source for cyanation. In both cases, good functional group tolerance was observed with very good to quantitative yields of products under metal/base/ligand‐free conditions. Several control experiments revealed that, water and oxygen from air are crucial for the efficiency of the present transformation. These reactions proceed through a radical pathway as confirmed by radical scavengers. To validate the feasibility of the process for commercial syntheses, three products were synthesized at gram scale under the optimized conditions. The conversion of cyanated products into corresponding amides and acid was also performed and the pure products were obtained without column chromatographic separation.