bluuebunny/crossref_metadata_2025_split huggingface dataset:
L‐theanine combination therapy with fluvoxamine in moderate‐to‐severe obsessive–compulsive disorder: A placebo‐controlled, double‐blind, randomized trial
Authors: Nematizadeh Mehran , Ghorbanzadeh Hossein , Moghaddam Hossein Sanjari , Shalbafan Mohammadreza , Boroon Mahsa , Keshavarz‐Akhlaghi Amir‐Abbas , Akhondzadeh Shahin 
Published: May 2023

AimThe main aim of this study was to investigate the additional effects of L‐theanine, an amino acid in tea and an analog of glutamate with neuroprotective and anti‐depressant properties, on obsessive–compulsive disorder (OCD) symptoms in combination with fluvoxamine.MethodsPatients from either sex aged between 18 and 60 years diagnosed with OCD, based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5), who had a Yale‐Brown Obsessive Compulsive Scale (Y‐BOCS) score of more than 21 were enrolled in a double‐blinded, parallel‐group, placebo‐controlled, clinical trial of 10 weeks to receive either L‐theanine (100 mg twice daily) and fluvoxamine (100 mg daily initially followed by 200 mg daily after week 5) or placebo and fluvoxamine. The primary outcome of interest in this study was the Y‐BOCS total score decrease from baseline.ResultsFrom a total of 95 evaluated patients, 50 completed our study; 30 were randomly assigned to each group. Multivariate analysis (ANOVA) showed a significant effect of time treatment for L‐theanine in obsession subscale (F = 5.51, P = 0.008) of the Y‐BOCS score but not in the total and compulsion scores. Our results showed significantly more improvement in obsession subscale scores in L‐theanine compared to placebo group (P = 0.007, Cohen's d = 0.82). Also, total Y‐BOCS scores were lower in L‐theanine compared to placebo group at week 5 (P = 0.039, Cohen's d = 0.60) and 10 (P = 0.008, Cohen's d = 0.80). However, there was no significant between‐group differences in compulsion subscale scores. Complete response was also more frequent in the L‐theanine group (P = 0.0001).ConclusionFindings in this study suggest L‐theanine as a relatively safe and effective adjuvant therapy for moderate to severe OCD.
“Property rights are human rights”: Bureaucratization and the logics of rule of law interventionism in postwar Kosovo
Authors: Mora Agathe 
Published: May 2023

AbstractWhat makes property restitution “successful” in postwar Kosovo? How are multiple, overlapping, and conflicting property regimes folded into the process of postwar transition? And what can the implementation of rule of law illuminate about international interventionism? Daily practices at the Kosovo Property Agency (KPA, the administrative, quasi‐judicial institution that the United Nations tasked with postwar property restitution) reveal the runaway effect of the growing bureaucratization of international human rights: institutional success is measured through neoliberal “technologies of accountability,” and the project itself becomes the key outcome. This is the result of a paradigm shift in global development that saw the legalization of property rights as a cornerstone of post‐conflict state‐building. A parallel shift towards managerialism and auditability in public sector management has given rise to demands for efficiency and accountability in transnational institutions. Together, these moves, which found fertile ground in Kosovo's reconstruction process and determined the mandate and institutional setup of property restitution, transform rule of law from an idealized public good to a shortsighted, box‐ticking exercise chiefly concerned with the production of measurable returns. These benchmarks sidestep the complicated historical legacies of property relations and entitlements and generate new forms of rights inequality.
Neural correlates of value‐driven spatial orienting
Authors: Liao Ming‐Ray , Kim Andy J. , Anderson Brian A. 
Published: May 2023

AbstractReward learning has been shown to habitually guide overt spatial attention to specific regions of a scene. However, the neural mechanisms that support this bias are unknown. In the present study, participants learned to orient themselves to a particular quadrant of a scene (a high‐value quadrant) to maximize monetary gains. This learning was scene‐specific, with the high‐value quadrant varying across different scenes. During a subsequent test phase, participants were faster at identifying a target if it appeared in the high‐value quadrant (valid), and initial saccades were more likely to be made to the high‐value quadrant. fMRI analyses during the test phase revealed learning‐dependent priority signals in the caudate tail, superior colliculus, frontal eye field, anterior cingulate cortex, and insula, paralleling findings concerning feature‐based, value‐driven attention. In addition, ventral regions typically associated with scene selection and spatial information processing, including the hippocampus, parahippocampal gyrus, and temporo‐occipital cortex, were also implicated. Taken together, our findings offer new insights into the neural architecture subserving value‐driven attention, both extending our understanding of nodes in the attention network previously implicated in feature‐based, value‐driven attention and identifying a ventral network of brain regions implicated in reward's influence on scene‐dependent spatial orienting.
Deep learning on independent spatial EEG activity patterns delineates time windows relevant for response inhibition
Authors: Gholamipourbarogh Negin , Vahid Amirali , Mückschel Moritz , Beste Christian 
Published: May 2023

AbstractInhibitory control processes are an important aspect of executive functions and goal‐directed behavior. However, the mostly correlative nature of neurophysiological studies was not able to provide insights which aspects of neural dynamics can best predict whether an individual is confronted with a situation requiring the inhibition of a response. This is particularly the case when considering the complex spatio‐temporal nature of neural processes captured by EEG data. In the current study, we ask whether independent spatial activity profiles in the EEG data are useful to predict whether an individual is confronted with a situation requiring response inhibition. We combine independent component analysis (ICA) with explainable artificial intelligence approaches (EEG‐based deep learning) using data from a Go/Nogo task (N = 255 participants). We show that there are four dissociable spatial activity profiles important to classify Go and Nogo trials as revealed by deep learning. Of note, for all of these four independent activity profiles, neural activity in the time period between 300 and 550 ms after stimulus presentation was most informative. Source localization analyses further revealed regions in the pre‐central gyrus (BA6), the middle frontal gyrus (BA10), the inferior frontal gyrus (BA46), and the insular cortex (BA13) were associated with the isolated spatial activity profiles. The data suggest concomitant processes being reflected in the identified time window. This has implications for the ongoing debate on the functional significance of event‐related potential correlates of inhibitory control.
Lower‐Class Reading in Late Imperial Russia
Authors: Badcock Sarah , Cowan Felix 
Published: May 2023

AbstractThis article demonstrates widespread engagement of lower‐class people with the written word in the late nineteenth and early twentieth century Russian Empire, in rural and urban locales, in homes, workplaces, and social spaces. We explore how lower‐class people read: the daily habits, personal relationships, and social spaces that shaped engagement with texts, and especially collective reading, a widespread phenomenon that extended the reach of the written word to less‐ or non‐literate audiences. Many lower‐class Russians experienced reading as a collective, public, aural activity, not a solitary, private, internal one. Reading was entwined with the rhythms of everyday social life and provoked critical thought and active engagement within countless lower‐class reading groups, as evidenced by collective letter‐writing and observations of post‐reading discussions. This article therefore contributes to scholarship exploring lower‐class Russians’ conscious and meaningful engagement with the textual world, and by association with late imperial Russia’s transforming social and political spheres.
School, Empire, and the Provincial Roots of Civil Activism in Late Nineteenth‐Century Russia
Authors: Valdman Alex 
Published: May 2023

AbstractIn spring 1879, news reached the Russian Ministry of Education that students from several Real Schools in the Russian Empire’s western provinces were planning to send a coordinated petition to the Minister of Education, asking for permission to enroll in university. The petition initiative was arranged in secrecy and involved more than a dozen schools from Odessa in the south to St. Petersburg in the north. Drawing on materials from several archives, this article traces the evolution of the petition initiative and addresses three main questions. First, the article demonstrates that the petition initiative was understood by students and officials alike as a severe breach of school discipline, but not a political crime, and it explains how and why the initiative is representative of the limited yet distinctive space of legitimation created by the authorities for non‐radical student activism. Second, it contextualizes the petition initiative against the backdrop of the discussion on civil activism in Russia, highlighting how secondary students were influenced and inspired by the contemporary public discourse and the idea of public activism. Finally, the article analyzes the internal social mechanisms of the petition initiative, demonstrating how it combined local self‐organization with imperial networking, mobility, and imagination.
THE CUMULATIVE QUALITY OF CULTURE EXPLAINS HUMAN UNIQUENESS
Authors: Legare Cristine 
Published: May 2023

AbstractWhat explains the unique features of human culture? Culture is not uniquely human, but human culture is uniquely cumulative. Cumulative culture is a product of our collective intelligence and is supported by cognitive processes and learning strategies that enable people to acquire, transform, and transmit information and technologies within and across generations. Technological and social innovations are currently driving unprecedented changes in cultural complexity and diversity. Innovation is a cognitively and socially complex, multistep process that typically requires (cumulative) cultural learning to achieve. I argue that the technological solutions that characterize twenty‐first‐century innovation can only be explained by understanding both the capacity to learn from and build upon the insights of others and the transmission systems that store the knowledge and technologies of previous generations. Human uniqueness is a product of cumulative cultural learning, transmission, and innovation.
Multi-Objective Optimization and Tradespace Analysis of a Mechanical Clock Movement Design
Authors: Xu Yifan , Turner Cameron , Wagner John 
Published: May 2023

Abstract
Pendulum clocks were the prevalent time keeping standard for centuries to regulate commerce and public activities. These mechanical movements were the most accurate timekeepers globally until replaced by electric clocks. Although mainly used for decorative purposes today, the pendulum clock's working principles and mechanical behavior can serve to demonstrate fundamental science and engineering concepts. The tradeoff between a clock's quality factor, pendulum properties, and period can best be explored with multiple objective optimization and tradespace analysis methods. In this project, a Multi-Objective Genetic Algorithm (MOGA-II) and a Multi-Objective Simulated Annealing (MOSA) optimization approaches are applied to evaluate a Graham escapement street clock for pendulum mass and time accuracy with a range of the period. These clock designs vary the pendulum length, pendulum bob radius, and bob thickness. Horological concepts are used to calculate the overall performance and general utility. The numerical results show a 0.7% increase in the quality factor, and a 0.56% reduction in the mass, while maintaining the designed period by modifying the clock parameters. More importantly, these changes can provide material cost savings in a mass production scenario. Overall, the study highlights the tradeoff designer engineers have considered for decades which can now be visualized using computer tools for greater insight.
Requirements for implementing a ‘just culture’ within healthcare organisations: an integrative review
Authors: Murray John S , Lee Jonathan , Larson Stacey , Range Amy , Scott Donald , Clifford Joan 
Published: May 2023

PurposeTo identify requirements for implementing a ‘just culture’ within healthcare organisations.MethodsUsing Whittemore and Knafl’s methodology for integrative reviews, we searched PubMed, PsychInfo, Cumulative Index of Nursing and Allied Health Literature, ScienceDirect, Cochrane Library and ProQuest Dissertations and Theses. Publications were considered eligible when reporting requirements for implementing a ‘just culture’ within healthcare organisations.ResultsAfter screening for inclusion and exclusion criteria, 16 publications were included in the final review. Four main themes were identified: leadership commitment, education and training, accountability and open communication.ConclusionThe themes identified in this integrative review provide some insight into the requirements for implementing a ‘just culture’ within healthcare organisations. To date, most of the published literature on ‘just culture’ is theoretical in nature. Additional efforts are needed to conduct research to explore further what requirements must be addressed in order to successfully implement a ‘just culture’ which is needed to promote and sustain a culture of safety.
Synthetic nicotine descriptors: awareness and impact on perceptions of e-cigarettes among US youth
Authors: Kowitt Sarah D , Seidenberg Andrew B , Gottfredson O’Shea Nisha C , Ritchie Caroline , Galper Emily F , Sutfin Erin L , Sheeran Paschal , Noar Seth M 
Published: May 2023

Background
Electronic cigarettes (e-cigarettes) are being advertised and sold with synthetic nicotine. Little research has examined youth awareness of synthetic nicotine or the impact of synthetic nicotine descriptors on perceptions of e-cigarettes.

Methods
Participants were a sample of 1603 US adolescents (aged 13–17 years) from a probability-based panel. The survey assessed knowledge of nicotine source in e-cigarettes (from ‘tobacco plants’ or ‘other sources besides tobacco plants’) and awareness of e-cigarettes containing synthetic nicotine. Then, in a between-subjects experiment with a 2×3 factorial design, we manipulated descriptors on e-cigarette products: (1) nicotine label (inclusion of the word ‘nicotine’: present or absent) and (2) source label (inclusion of a source: ‘tobacco-free’, ‘synthetic’ or absent).

Results
Most youth were either unsure (48.1%) or did not think (20.2%) that nicotine in e-cigarettes comes from tobacco plants; similarly, most were unsure (48.2%) or did not think (8.1%) that nicotine in e-cigarettes comes from other sources. There was low-to-moderate awareness of e-cigarettes containing synthetic nicotine (28.7%), with higher awareness among youth who use e-cigarettes (48.0%). While no main effects were observed, there was a significant three-way interaction between e-cigarette status and the experimental manipulations. The ‘tobacco-free nicotine’ descriptor increased purchase intentions relative to ‘synthetic nicotine’ (simple slope: 1.20, 95% CI 0.65 to 1.75) and ‘nicotine’ (simple slope: 1.20, 95% CI 0.67 to 1.73) for youth who use e-cigarettes.

Conclusions
Most US youth do not know or have incorrect beliefs about the sources of nicotine in e-cigarettes and describing synthetic nicotine as ‘tobacco-free nicotine’ increases purchase intentions among youth who use e-cigarettes.
Accelerated Verifiable Fair Digital Exchange
Authors: Banerjee Prabal , Behl Dushyant , Kodeswaran Palanivel , Kumar Chaitanya , Ruj Sushmita , Sen Sayandeep , Vinayagamurthy Dhinakaran 
Published: May 2023

A Fair Digital Exchange is defined as either all or none of the participants achieving a (predetermined) desirable outcome. This work addresses third party mediated systems for digital content where mutually unknown, and hence non-trusting, buyers, sellers and the mediator (third party) take part in an exchange protocol. We address the lack of guaranteed fairness, as defined above, in the existing platforms for this setting. We present TEDX, a decentralized solution for guaranteed three party fair exchange of digital goods with scalability and support for incremental deployment over the existing (non-fair) platforms. TEDX combines carefully crafted message exchanges with incentive schemes designed to deter malicious behavior. TEDX also leverages ideas from blockchain anchored state-channels to provide trusted execution while minimizing the operational overheads of blockchain.
We present the design and a security analysis of TEDX to validate the claimed fairness properties. We also present the details of a prototype implementation of TEDX leveraging Hyperledger Fabric and performance evaluation of the same on a realistic testbed spanning five public cloud zones. Our results indicate that TEDX adds only a minimal overhead of 16% while being 46x faster than a naive blockchain solution, thereby demonstrating that TEDX is scalable.
Systematic Electrophysiological Study Prior to Pulmonary Valve Replacement in Tetralogy of Fallot: A Prospective Multicenter Study
Authors: Waldmann Victor , Bessière Francis , Gardey Kevin , Bakloul Mohamed , Belli Emre , Bonnet Damien , Chaussade Anne-Solène , Cohen Sarah , Delasnerie Hubert , Dib Nabil , Di Filippo Sylvie , Dulac Arnaud , Hascoët Sébastien , Henaine Roland , Iserin Laurence , Karsenty Clément , Ladouceur Magalie , Legendre Antoine , Malekzadeh-Milani Sophie , Mostefa Kara Mansour , Radojevic Jelena , Ratsimandresy Miarisoa , Marijon Eloi , Maltret Alice , Khairy Paul , Combes Nicolas 
Published: May 2023

Background:
Ventricular arrhythmias and sudden death are recognized complications in tetralogy of Fallot. Electrophysiological studies (EPS) before pulmonary valve replacement (PVR), the most common reintervention in tetralogy of Fallot, could potentially inform therapy to improve arrhythmic outcomes.

Methods:
A prospective multicenter study was conducted to systematically assess EPS with programmed ventricular stimulation in patients with tetralogy of Fallot referred for PVR from January 2020 to December 2021. A standardized stimulation protocol was used across all centers.

Results:
A total of 120 patients were enrolled, mean age 39.2±14.5 years, 53.3% males. Sustained ventricular tachycardia was induced in 27 (22.5%) patients. When identifiable, the critical isthmus most commonly implicated (ie, in 90.0%) was between the ventricular septal defect patch and pulmonary annulus. Factors independently associated with inducible ventricular tachycardia were history of atrial arrhythmia (odds ratio, 8.56 [95% CI, 2.43–34.73]) and pulmonary annulus diameter >26 mm (odds ratio, 5.05 [95% CI, 1.47–21.69]). The EPS led to a substantial change in management in 23 (19.2%) cases: 18 (15.0%) had catheter ablation, 3 (2.5%) surgical cryoablation during PVR, and 9 (7.5%) defibrillator implantation. Repeat EPS 5.1 (4.8–6.2) months after PVR was negative in 8 of 9 (88.9%) patients. No patient experienced a sustained ventricular arrhythmia during 13 (6.1–20.1) months of follow-up.

Conclusions:
Systematically performing programmed ventricular stimulation in patients with tetralogy of Fallot referred for PVR yields a high rate of inducible ventricular tachycardia and carries the potential to alter management. It remains to be determined whether a standardized treatment approach based on the results of EPS will translate into improved outcomes.

Registration:

URL:
https://clinicaltrials.gov/ct2/show/NCT04205461
; Unique identifier: NCT04205461
Systematic Review of Therapeutic Agents and Long-Term Outcomes of Familial Hyperaldosteronism Type 1
Authors: Tan Shu Ting , Boyle Veronica , Elston Marianne S. 
Published: May 2023

Background:
Familial hyperaldosteronism type 1 (FH1), previously known as glucocorticoid-remediable aldosteronism, was the first identified monogenic cause of primary aldosteronism. Patients classically develop hypertension at a young age and are at risk of premature vascular complications. A systematic review of FH1 was performed to determine long-term treatment outcomes.

Methods:
Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted searches with a patient/population, intervention, comparison and outcomes (PICO) framework using Embase, Medline, PubMed, Scopus, and Web of Science databases to identify patients with FH1 prescribed either no treatment with a minimum 3 months follow-up or medical treatment of at least 3 months duration.

Results:
A total of 99 FH1 cases were identified from 42 studies. Most had early-onset hypertension but variable hypokalemia, hyperaldosteronism, and hyporeninemia. Of the 62 cases with a reported age of FH1 diagnosis, median age was 18 ± 17.6 years old. Of those treated, 72% received a glucocorticoid for long-term treatment compared with 22% receiving a potassium-sparing diuretic. Data on long-term treatment and disease side effects, complications, and outcomes were seldom reported. However, of 20 patients with reported complications, premature vascular complications were evident with the median age of diagnosis for left ventricular hypertrophy and hypertensive retinopathy 15 and 16.5 years old respectively, the youngest age of aortic dissection age 10 years, and those with reported cerebrovascular history had strokes or transient ischemic attacks before age 40 years.

Conclusions:
Major gaps in the literature around FH1 patients’ long-term treatment and disease outcomes still exist. Long-term outcome data are required to help inform clinicians of the best long-term treatment for FH1.
A Traveling Waves Perspective on Temporal Binding
Authors: Alamia Andrea , VanRullen Rufin 
Published: May 2023

Abstract
Brain oscillations are involved in many cognitive processes, and several studies have investigated their role in cognition. In particular, the phase of certain oscillations has been related to temporal binding and integration processes, with some authors arguing that perception could be an inherently rhythmic process. However, previous research on oscillations mostly overlooked their spatial component: how oscillations propagate through the brain as traveling waves, with systematic phase delays between brain regions. Here, we argue that interpreting oscillations as traveling waves is a useful paradigm shift to understand their role in temporal binding and address controversial results. After a brief definition of traveling waves, we propose an original view on temporal integration that considers this new perspective. We first focus on cortical dynamics, then speculate about the role of thalamic nuclei in modulating the waves, and on the possible consequences for rhythmic temporal binding. In conclusion, we highlight the importance of considering oscillations as traveling waves when investigating their role in cognitive functions.