bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUCCESSFUL MYOCARDIAL REVASCULARIZATION IN A 92-YEAR-OLD FEMALE PATIENT: A CASE REPORT
Authors: Pidvalna Uliana , Bodak Petro , Vyshynska Sophia , Beshley Dmytro 
Published: April 2023

Introduction. Patients with acute myocardial infarction should be treated with early revascularization. Patients over 73 years have a higher risk of infarct-related cardiogenic shock, which is a leading cause of lethality. Unfortunately, little is known about myocardial revascularization care for elderly people in Ukraine. We presented a 92-year-old lady with an acute chest pain case report, which was not revealed by analgesics.
Important clinical findings. Coronary angiography revealed thrombotic occlusion of the distal segment of the left anterior descending artery (LAD) and floated thrombus in LAD mid-segment; stenosis of the left circumflex artery (LCx) close to the first obtuse marginal artery (OM1).
The main diagnosis. Acute myocardial infarction with ST-segment elevation of the left ventricle anterior wall (anterior-STEMI). Calcific aortic valve disease, severe aortic valve stenosis, significant mitral and tricuspid valve regurgitation, pulmonary hypertension. Heart failure with reduced LVEF (<40%), NYHA class III symptoms.
Intervention. The decision was to perform urgent stenting in LAD and balloon angioplasty in LCx. Successful hospital discharge was after 14 days.
Conclusions. Take-away lessons: Elderly patients with acute myocardial infarction can be successfully treated in Ukraine. Age and comorbidities are not a contraindication for early myocardial revascularization.
Romantic myths and cyber dating violence victimization in Spanish adolescents: A moderated mediation model
Authors: Cava María-Jesús , Castillo Isabel , Tomás Inés , Buelga Sofía 
Published: April 2023

Adolescents’ beliefs in romantic myths of love have been related to cyber dating violence victimization. However, these relationships could be mediated by adolescents’ tolerant attitudes toward dating abuse and be different for adolescent boys and girls. A better understanding of these relationships is important for developing more effective prevention programs. Thus, the current study aimed to examine the relationships between beliefs in romantic myths and cyber dating violence victimization in adolescents, analyzing the possible mediating role of tolerant attitudes toward abuse and the possible moderator role of gender. Participants were 467 Spanish adolescents who had a romantic relationship (54.4% girls; Mage = 15.09). Results showed positive significant direct and indirect relationships, through tolerant attitudes toward abuse, between beliefs in romantic myths and cyber dating violence victimization. Gender was not a moderator variable in the direct relationships, but its moderator role was supported in the indirect relationships. Stronger positive links between romantic myths and tolerant attitudes toward abuse, and between tolerant attitudes and cyber-control victimization, were found in adolescent girls. These findings highlight the need to consider tolerant attitudes toward abuse in intervention programs designed to prevent cyber dating violence victimization in adolescents and continue to analyze gender differences in variables related to cyber dating violence victimization.
Culturas energéticas: proyecto de concienciación sobre el uso eficiente de la energía en los hogares
Authors: Alcaraz Corbella Mariona , Bas Mantilla Anaïs 
Published: April 2023

Culturas Energéticas es un proyecto de concienciación sobre el uso eficiente
de la energía en los hogares orientado a codiseñar procesos de mejora energética
en edificios residenciales. El propio proceso de aprendizaje abre también
una puerta a la cohesión de las comunidades y el fortalecimiento de la cooperación
entre todas las personas que utilizan los edificios.
La necesidad de un proceso transformador en nuestra sociedad para mitigar
y adaptarse a los efectos del cambio climático implica la adopción de
soluciones que den respuesta a las diferentes facetas de nuestra realidad de
manera integrada. Si bien, las propuestas para reducir el uso de energía en
los edificios se han enfocado tradicionalmente a los aspectos físicos, tecnológicos
o económicos del medio construido, más recientemente, las diferentes
directivas europeas relativas a la eficiencia energética de los edificios sostienen
que la reducción del consumo de energía está afectada no sólo por cómo los
edificios están diseñados y construidos sino también por cómo están gestionados
y utilizados.
Desde esta perspectiva, el modelo teórico utilizado para el desarrollo de la
definición, el contenido y las herramientas del proyecto, emplea el marco
conceptual de Culturas Energéticas diseñado por un equipo multidisciplinar
de investigadores de distintos ámbitos como física, economía, derecho, psicología
y sociología.
Energy Cultures is an awareness project on the efficient use of energy in homes aimed at co-designing energy improvement processes in residential buildings. The learning process itself also opens a door to the cohesion of the communities and the strengthening of cooperation between all the people who use the buildings. The need for a transformative process in our society to mitigate and adapt to the effects of climate change implies the adoption of solutions that respond to the different facets of our reality in an integrated way. Although proposals to reduce the use of energy in buildings have traditionally focused on the physical, technological or economic aspects of the built environment, more recently, the different European directives regarding the energy efficiency of buildings maintain that the reduction of Energy consumption is affected not only by how buildings are designed and built but also by how they are managed and used. From this perspective, the theoretical model used for the development of the definition, content and tools of the project, uses the conceptual framework of Energy Cultures designed by a multidisciplinary team of researchers from different fields such as physics, economics, law, psychology and sociology
La arquitectura en la imagen de la ciudad: sobre mojones y monumentos
Authors: Espinosa Marcelo 
Published: April 2023

El presente artículo plantea un análisis comparativo entre dos de los textos más importantes de la arquitectura del siglo XX, La Arquitectura de la Ciudad de Aldo Rossi y La Imagen de la Ciudad de Kevin Lynch, el trasfondo de dicha comparación va más allá de la relación manifiesta entre arquitectura y ciudad, se focaliza en la elección de las categorías - Mojón y Monumento como elementos particulares a analizar, para esto el ensayo se plantea un problema específico, las convergencias y distancias entre ambas interpretaciones de la potencia de la arquitectura en la construcción, vida y vivencia de la ciudad. En el caso de Rossi es la arquitectura el objeto por medio del cual se puede afrontar el problema de la ciudad, en tanto Lynch asume que no es la arquitectura sino la ciudad el medio por el cual se resuelven los problemas de la sociedad. Para esto se contextualizan ambas obras y se precisa la identificación de los métodos y conceptos que las organizan, para establecer parámetros objetivos y una correcta caracterización de los elementos a comparar.
This article presents a comparative analysis between two of the most important essays of the twentieth century architecture, The Architecture Of The City of Aldo Rossi and The Image Of The City of Kevin Lynch, the background of this comparison goes beyond the undeniable relationship between architecture and city, focusing on the selection of categories -Landmark and Monument- as particular elements to be analyzed. This essay is approached through a specific problem, the confluences and distances between both interpretations of the power of architecture in the construction, life and experience of the city. In the case of Rossi, architecture is the object through which the problem of the city can be addressed, while Lynch assumes that it is not architecture but the city that is the means by which societal problems are solved. For this, both papers are contextualized, and the identification of methods and concepts that organize them is required to establish objective parameters and a correct description of the compared elements.
Transcription Factor Immunohistochemistry in the Classification of Pituitary Neuroendocrine Tumor/Adenoma: Proposal in a Limited-Resource Setting
Authors: Sood Ridhi , Chatterjee Debajyoti , Dutta Pinaki , Radotra Bishan Dass 
Published: April 2023

Context.—
Pituitary neuroendocrine tumors/adenomas are common intracranial tumors that require accurate subtyping because each tumor differs in its biologic behavior and response to treatment. Pituitary-specific transcription factors allow for improved lineage identification and diagnosis of newly introduced variants.

Objective.—
To assess the usefulness of transcription factors and design a limited panel of immunostains for classification of pituitary neuroendocrine tumors/adenoma.

Design.—
A total of 356 tumors were classified as per expression of pituitary hormones and transcription factors T-box family member TBX19 (TPIT), pituitary-specific POU-class homeodomain (PIT1), and steroidogenic factor-1 (SF-1). The resultant classification was correlated with patients’ clinical and biochemical features. The performance and relevance of individual immunostains were analyzed.

Results.—
Reclassification of 34.8% (124 of 356) of pituitary neuroendocrine tumors/adenoma was done after application of transcription factors. The highest agreement with final diagnosis was seen using a combination of hormone and transcription factors. SF-1 had higher sensitivity, specificity, and predictive value compared with follicle-stimulating hormone and luteinizing hormone. On the other hand, TPIT and PIT1 had similar performance and Allred scores compared with their respective hormones.

Conclusions.—
SF-1 and PIT1 should be included in the routine panel for guiding the classification. PIT1 positivity needs to be followed by hormone immunohistochemistry, especially in nonfunctional cases. TPIT and adrenocorticotropin can be used interchangeably as per availability of the lab.
Updated Salivary Gland Immunohistochemistry: A Review
Authors: Swid Mohammed Amer , Li Liping , Drahnak Erin M. , Idom Hayden , Quinones William 
Published: April 2023

Context.—
Salivary gland neoplasms are rare lesions in the head and neck (H&N) pathology realm. There are more than 20 malignant and 15 benign salivary gland neoplasms in the 5th edition of the World Health Organization classification of H&N tumors. These neoplasms consist of heterogeneous groups of uncommon diseases that make diagnosis and treatment challenging for the clinical team. Using an algorithmic immunohistochemical approach–defined tumor origin and type has proven to be effective and advantageous. Immunohistochemistry may be used as sort of a “diagnostic looking glass,” not as a positive or negative type tool, but as an indispensable complement to a hematoxylin-eosin morphologic pattern–based approach. Furthermore, the understanding of the novel discoveries of the salivary gland gene fusions and the molecular aspects of these tumors makes the process easier and improve the diagnosis as well as treatment aspects. This review reflects our experience with more recent diagnostic antibodies, which include MYB RNA, Pan-TRK, PLAG1, LEF1, and NR4A3. Each of these is linked with a specific type of neoplasm; for example, gene fusions involving the PLAG1 and HMGA2 oncogenes are specific for benign pleomorphic adenomas, and MYB is associated with adenoid cystic carcinoma.

Objective.—
To review these more recent antibodies, which highly enhance salivary gland neoplasm diagnosis.

Data Sources.—
The study sources involved literature PubMed searches, including multiple review articles, case reports, selected book chapters, and Geisinger Medical Center cases.

Conclusions.—
Salivary gland tumors are a rare, varied group of lesions in H&N pathology. We need to have continuous readings and revisions of the molecular consequences of these fusion oncoproteins and their subsequent targets, which will eventually lead to the identification of novel driver genes in salivary gland neoplasms.
Exploring the Diversification in Grafted Copolymer
Authors: Ashish Chauhan  , Balbir Kaith  
Published: April 2023

The paper deals with optimization of the reaction parameters, graft copolymerization, characterizationand evaluation of the transformations in Roselle stem fiber on graft copolymerization with vinyl monomer, using cericammonium nitrate nitric acid initiator system. Methods: Different reaction parameters such as temperature, time, initiatorconcentration, monomer concentration and pH were optimized to get the maximum graft yield. The graft copolymer thusformed were characterized by advanced techniques. Results: The physico-chemico-thermal resistance, moisture absorbance,swelling behavior of graft copolymers and the dye uptake behavior were studied and found to have improved.
Conclusion:Hence, this first report of novel graft copolymers is to help towards various applications.
Assessment of DNA damage in pulmonary tuberculosis patients by single cell gel electrophoresis / comet assay
Authors: M.P. Narmadha  , A. S. Ushananthini  , A. Murugan  , R. Saravanan  , D. Sridhar  
Published: April 2023

Background: The role of antitubercular drugs as anti bacterial agents on mycobacterium tuberculi is established.However their impact on human cell is not much explored. Objective: The present study was aimed to determine theextent of cell damage in Pulmonary Tuberculosis patients with the help of comet assay. This is a prospective studycarried out in Tiruchengodu Govt. Hospital from September 2011 to April 2012. Blood samples were collected from100 subjects [Healthy volunteers (Go), newly diagnosed TB patients (G1), Three months treated TB patients (G2), Sixmonths treated TB patients (G3). n=25 subjects in each group]. Methodology: Blood samples from anticubital veinwere collected, embedded in agarose gel, lysed in high ionic strength solution with Triton X-100, and thenelectrophoresed at pH>13, ethidium bromide stained were then subjected to analysis under Fluorescent microscope.Results: Subjects of newly diagnosed TB (G1) patients did not show any remarkable cell damage as compared to TBpatients under treatment. Extent of cell damage in six months treated TB patients (G3) was greater than three monthstreated TB patients (G2) (P<0.0001). Among quantitative comet metrics, comet length was significantly greater inmales compared with females (P= <0.0003). Extent of cell damage was observed significantly high in anti-tuberculardrug treatment patients both three months treated and six months treated TB patients.
Conclusion: DNA damage wasfound to be significantly increased in smoking & alcoholic tuberculosis patients. Anti-tubercular drug and social habitsseem to be the major contributor of the cell damage
Assessing of the economies of scale and scope in th e Tunisian health sector
Authors: Boukthir Tayaa  , Boujelbene Younes  
Published: April 2023

In this paper, we attempt to estimate hospital marg inal’s costs and evaluate economies of scale as wel l as scope economies using a generalized multiproduct cost function.
In our esti mation we use a sample of Tunisian academic hospita ls with two categories, namely, general hospitals and specialized ones. Ela borating a separate evaluation of how the behaviour of different types of hospitals might be helpful particularly for a bette r resource allocation and a more efficient decision making relative to academic health institutions.Eventually, one might well ded uce that, in the first place, the marginal cost per admission turns out to differ slightly with regard to both sets of hospital categ ories. Yet, the marginal cost per total ambulatory has shown a relatively greater difference compared to the marginal admission cost. In the second place, our results have led to the c onclusion that both sets of health care service organizations do not exhibit no ticeable differences regarding economies of scale. In addition, the empirical findings have also shown that economies of scope tu rn out to prevail predominantly within hospital hea lth care services in Tunisia throughout the study period, which is the subject o f our analysis.
Complicaciones de Rickettsiosis debido al Diagnóstico Tardío en el Paciente Pediátrico
Authors: Cano-Rangel Manuel A. , Buzani-Peña Adriana E. , Páez-Douriet Dario , Ramón-Ríos Alberto , Ramírez-Mexía Alberto , Ramírez-Mexía Manuel R. 
Published: April 2023

Las rickettsiosis son un grupo de enfermedades causadas por cocobacilos gramnegativos del género Rickettsia que se distribuyen entre vectores artrópodos hematófagos como las garrapatas, pulgas, piojos o ácaros. Dentro del estado de Sonora, esta toma un papel de mayor importancia dada la naturaleza del clima seco, el cual favorece su prevalencia e incidencia año con año; por esto mismo, es considerada como una enfermedad endémica del estado y de importancia epidemiológica.
El cuadro clínico común se caracteriza por episodios febriles, mialgias, cefalea y malestar general, lo que la convierte en un reto diagnóstico para el médico de primer contacto por sus manifestaciones tan inespecíficas, haciéndola susceptible a desarrollar complicaciones, especialmente si no se realiza un diagnóstico o sospecha temprana que nos permita comenzar con una terapia adecuada, principalmente en pacientes pediátricos, donde las complicaciones son severas y suelen ser catastróficas tanto para los familiares como para el paciente. Estas comúnmente se relacionan con falla multiorgánica, donde se encuentran involucrados los sistemas neurológico, renal, vascular y hepático; y se debe considerar que todas estas pueden culminar en la muerte del paciente.
Actualmente, la literatura científica se encuentra limitada con respecto a la información de rickettsiosis en pacientes pediátricos y sus posibles complicaciones, por lo que este artículo busca difundir la información necesaria en estos escenarios, con el objetivo de evitar subestimar el diagnóstico dentro de la población pediátrica, ya que es uno de los grupos más vulnerables a exponerse a la enfermedad, así como sus posibles complicaciones debido a la incapacidad de comunicar objetivamente su padecimiento.
L’enchantement de la machine : la nature systémique du néo-matérialisme
Authors: Leduc Claude 
Published: April 2023

À l’anthropocentrisme et au dualisme épistémologique propre au sujet cartésien et
moderne, le néo-matérialisme oppose une ontologie relationnelle caractérisée par des
agencements où l’ensemble des objets – des « actants » – s’affectent mutuellement et
produisent ainsi de concert un environnement dynamique. L’étude critique de ce courant
théorique révèle un accord profond avec la pensée des systèmes. Le néo-matérialisme s’appuie
en effet sur une critique de la représentation qui résonne fortement avec l’idéologie
associée aux technologies de l’information et de la communication issues de la cybernétique.
De même, le modèle sociétal qu’on peut tirer du néo-matérialisme s’accorde avec celui qu’on
peut associer au marché néolibéral, « l’enchantement » que suscite censément une matière
investie d’une dynamique vitaliste consacrant en réalité la mise en marchandise de tout
l’être. En nous inspirant notamment du travail de Michel Freitag, nous démontrons que le
néo-matérialisme constitue un exemple parfait de l’extension du monisme opérationnel en
sciences humaines, à mesure que la production de la connaissance s’arrime au problem
solving indissociable de la gestion technocratique du social.
Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1
Authors: Wang Zijia , Han Ying , Peng Ying , Shao Shuhui , Nie Huanquan , Xia Kun , Xiong Haofeng , Su Tong 
Published: April 2023

Objectives
Cellular senescence is strongly associated with fibrosis and tumorigenesis. However, whether the epithelium of oral submucous fibrosis (OSF) undergoes premature senescence remains unclear. This study investigates the roles of senescent epithelial cells in OSF.

Methods
The immunohistochemistry and Sudan black B staining were performed to identify epithelium senescence in OSF tissues. Arecoline was used to induce human oral keratinocytes (HOKs) senescence. The cell morphology, senescence-associated β galactosidase activity, cell counting Kit 8, immunofluorescence, quantitative real-time PCR, and western blot assay were used to identification of senescent HOKs. The enzyme-linked immunosorbent assay was exerted to evaluate the levels of transforming growth factor β1 (TGF-β1) in the supernatants of HOKs treated with or without arecoline.

Results
The senescence-associated markers, p16 and p21, were overexpressed in OSF epithelium. These expressions were correlated with alpha-smooth actin (α-SMA) positively and proliferating cell nuclear antigen (PCNA) negatively. Moreover, Sudan black staining showed that there was more lipofuscin in OSF epithelium. In vitro, HOKs treated with arecoline showed senescence-associated characteristics including enlarged and flattened morphology, senescence-associated β galactosidase staining, cell growth arrest, γH2A.X foci, upregulation of p53, p21, and TGF-β1 protein levels. Moreover, senescent HOKs secreted more TGF-β1.

Conclusions
Senescent epithelial cells are involved in OSF progression and may become a promising target for OSF treatment.
Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis
Authors: Congur Irem , Koni Ekin , Onat Onur Emre , Tokcaer Keskin Zeynep 
Published: April 2023

Background
Leptomeningeal carcinomatosis (LMC) is a rare type of cancer that settles at the meninges through metastasis of non-small cell lung cancer (NSCLC), breast cancer and melanoma. The molecular mechanism underlying LMC is not known, therefore molecular studies investigating the development of LMC are needed. Here, we aimed to identify commonly mutated genes in LMC caused by NSCLC, breast cancer, and melanoma using an in-slico approach and their interactions using integrated bioinformatic approaches/tools in this meta-analysis.

Methods
We conducted a meta-analysis using information from 16 studies that included different sequencing techniques of patients with LMC caused by three different primary cancers: breast cancer, NSCLC, and melanoma. All studies that assessed mutation information from patients with LMC were searched in PubMed, from their inception to February, 16 2022. Studies that performed NGS on LMC patients with NSCLC, breast cancer, or melanoma were included, while studies that did not apply NGS to CSF samples, did not provide information on altered genes, were reviews, editorials, or conference abstracts, or whose main goal was the detection of malignancies were all excluded. We identified commonly mutated genes in all three types of cancer. Next, we constructed a protein-protein interaction network, then performed pathway enrichment analysis. We searched National Institutes of Health (NIH) and Drug-Gene Interaction Database (DGIdb) to find candidate drugs.

Results
We found that TP53, PTEN, PIK3CA, IL7R, and KMT2D genes were commonly mutated genes in all three types of cancer via our meta-analysis that consisted out of 16 studies. Our pathway enrichment analysis showed that all five genes were primarily associated with regulation of cell communication and signaling, and cell proliferation. Other enriched pathways included regulation of apoptotic processes of leukocytes and fibroblasts, macroautophagy and growth. According to our drug search we found candidate drugs; Everolimus, Bevacizumab and Temozolomide, which interact with these five genes.

Conclusion
In conclusion, a total of 96 mutated genes in LMC were investigated via meta-analysis. Our findings suggested vital roles of TP53, PTEN, PIK3CA, KMT2D, and IL7R, which can provide insight into the molecular basis of LMC development and paving the door to the development of new targeted medicine and will encourage molecular biologists to seek biological evidence.