bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence evaluation of coronary computed tomography angiography for coronary stenosis classification and diagnosis
Authors: Lee Dan‐Ying , Chang Chun‐Chin , Ko Chieh‐Fu , Lee Yin‐Hao , Tsai Yi‐Lin , Chou Ruey‐Hsing , Chang Ting‐Yung , Guo Shu‐Mei , Huang Po‐Hsun 
Published: September 2023

AbstractBackgroundRuling out obstructive coronary artery disease (CAD) using coronary computed tomography angiography (CCTA) is time‐consuming and challenging. This study developed a deep learning (DL) model to assist in detecting obstructive CAD on CCTA to streamline workflows.MethodsIn total, 2929 DICOM files and 7945 labels were extracted from curved planar reformatted CCTA images. A modified Inception V3 model was adopted. To validate the artificial intelligence (AI) model, two cardiologists labelled and adjudicated the classification of coronary stenosis on CCTA. The model was trained to differentiate the coronary artery into binary stenosis classifications <50% and ≥50% stenosis. Using the quantitative coronary angiography (QCA) consensus results as a reference standard, the performance of the AI model and CCTA radiology readers was compared by calculating Cohen's kappa coefficients at patient and vessel levels. The net reclassification index was used to evaluate the net benefit of the DL model.ResultsThe diagnostic accuracy of the AI model was 92.3% and 88.4% at the patient and vessel levels, respectively. Compared with CCTA radiology readers, the AI model had a better agreement for binary stenosis classification at both patient and vessel levels (Cohen kappa coefficient: .79 vs. .39 and .77 vs. .40, p < .0001). The AI model also exhibited significantly improved model discrimination and reclassification (Net reclassification index = .350; Z = 4.194; p < .001).ConclusionsThe developed AI model identified obstructive CAD, and the model results correlated well with QCA results. Incorporating the model into the reporting system of CCTA may improve workflows.
Life history of the leaf‐feeding beetle Calomela intemerata, a potential biocontrol agent against Acacia auriculiformis
Authors: Sanderson Christine H. , Zonneveld Ryan , Smith Melissa C. , Minteer Carey R. , Purcell Matthew F. 
Published: September 2023

AbstractWe examined the biology and life history of Calomela intemerata Lea (Coleoptera: Chrysomelidae), to determine its potential as a biocontrol agent of Acacia auriculiformis A.Cunn. ex Benth. (Fabaceae), an environmental weed in Florida, USA. We analysed data from field surveys in northern Australia and determined life‐history parameters and larval feeding under controlled laboratory conditions. In the field, both larvae and adults of C. intemerata fed throughout the year on young shoots of A. auriculiformis. Two geographically isolated populations of C. intemerata were collected from Northern Territory and north Queensland, Australia. We examined developmental time, survival, and size of immature stages in the laboratory at 25 °C. Following development through four instars, larvae move to the soil for pupation. Egg‐to‐adult development was approximately 23 days. Adults were long‐lived – several individuals survived >8 months. Females began ovipositing about 8 days after emergence and laid on average >1000 eggs each. On the invasive Florida A. auriculiformis, larvae of the Northern Territory population performed better than the north Queensland population regarding leaf consumption and developmental rate. The biological attributes of C. intemerata such as short generation time, high fecundity, and a long adult life, combined with the extensive damage larvae and adults inflict to young vegetative growth when feeding, make it a promising candidate biocontrol agent for management of A. auriculiformis in Florida. Formal host specificity testing is currently underway in Florida.
First report of Quambalaria eucalypti in young Eucalyptus plants in field conditions in Brazil
Authors: Santos Gizeli S. , Mafia Reginaldo G. , Zarpelon Talyta G. , Soares Thaissa P. F. , Ferreira Maria A. 
Published: September 2023

AbstractThe genus Quambalaria includes several important pathogens of Eucalyptus and Corymbia spp., mainly those that cause leaf and shoot blight. The species Quambalaria eucalypti has been reported to be an aetiological agent of this disease in Brazil only in nurseries involved in the production of Eucalyptus minicuttings, where climatic conditions are more favourable for the pathogen. The aim of this study was to identify the pathogen that causes a similar disease in young Eucalyptus trees. For this, we used morphological characteristics, pathogenicity tests and DNA sequence data. Sequences of four isolates obtained from leaves and cankers were compared to 17 sequences deposited in GenBank. Twenty‐one isolates were subjected to multilocus analyses of internal transcribed spacer (ITS) and rDNA large subunit (LSU) sequence information. The resulting consensus tree showed that isolates in this study could be grouped with Q. eucalypti into one distinct clade, and the morphological characteristics were similar to those described in the literature. The pathogenicity was confirmed, and the pathogen was re‐isolated from inoculated plants, confirming Koch's postulates. This is the first record of Q. eucalypti causing leaf and shoot blight on young Eucalyptus plants in field conditions in Brazil. The presence of this disease in nurseries and its occurrence in the field is cause for alarm in Eucalyptus breeding programmes in Brazil.
Entrepreneurial intention studies: A hybrid bibliometric method to identify new directions for theory and research
Authors: Loi Michela , Castriotta Manuel , Barbosa Saulo Dubard , Di Guardo M. Chiara , Fayolle Alain 
Published: September 2023

AbstractFragmentation is the main obstacle to scientific progress on entrepreneurial intention. To address this issue, we systematise the current literature with a hybrid bibliometric method that combines co‐citation and bibliographic coupling analysis for the first time in entrepreneurial intention studies to show the field's knowledge base and research fronts and to examine how divergent perspectives have challenged the core knowledge of the field. We highlight three recurring dimensions of entrepreneurial intention studies: (1) personal factors, (2) social factors and (3) investigational settings. In addition to introducing new constructs, divergent perspectives have emphasised the interplay between these components and challenged the mechanisms connecting them. Based on these findings, we extend previous classifications in the literature by providing a framework that integrates divergent perspectives with the field's knowledge base, helping establish future research avenues and improving the theorising process of entrepreneurial intention.
Adsorption prospects of ultrafine, cubic 8 mol.% Y2O3‐stabilized ZrO2 nanoparticles
Authors: Ameta Pranav , Bokka Sravan , Lakshya Annu Kumar , Chowdhury Anirban 
Published: September 2023

AbstractYttria‐stabilized zirconia (YSZ), although well known for a lot of excellent engineering applications, has limited footprints in the field of adsorption/dye removal. Through this work, we demonstrate the remarkable efficacy (adsorption capacity ∼550 mg/g) of 8 mol.% YSZ nano‐adsorbents for toxic azo‐dye (e.g., Congo red) removal. The consistency of our adsorption experiments was validated with the help of a series of tests, such as regeneration (via thermal and chemical routes), in real‐life river water, with mixed ion solution, and under varied pH (3–11). Noteworthy is also that the commercial trademark composition (with the same dopant concentration) showed little/no adsorption. Our success of the adsorption experiments is credited to the multitude of factors, namely, size refinement ∼6 nm, retainment of phase‐pure cubicity, and enhanced surface area (155 m2/g), which eventually led to the generation of massive oxygen vacancies on our synthesized doped‐zirconia surfaces.
Design and preclinical testing of an anti‐CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia
Authors: Tigu Adrian Bogdan , Constantinescu Catalin Sorin , Teodorescu Patric , Kegyes David , Munteanu Raluca , Feder Richard , Peters Mareike , Pralea Ioana , Iuga Cristina , Cenariu Diana , Marcu Andra , Tanase Alina , Colita Anca , Drula Rares , Bergthorsson Jon Thor , Greiff Victor , Dima Delia , Selicean Cristina , Rus Ioana , Zdrenghea Mihnea , Gulei Diana , Ghiaur Gabriel , Tomuleasa Ciprian 
Published: September 2023

AbstractAcute megakaryoblastic leukaemia (AMkL) is a rare subtype of acute myeloid leukaemia (AML) representing 5% of all reported cases, and frequently diagnosed in children with Down syndrome. Patients diagnosed with AMkL have low overall survival and have poor outcome to treatment, thus novel therapies such as CAR T cell therapy could represent an alternative in treating AMkL. We investigated the effect of a new CAR T cell which targets CD41, a specific surface antigen for M7‐AMkL, against an in vitro model for AMkL, DAMI Luc2 cell line. The performed flow cytometry evaluation highlighted a percentage of 93.8% CAR T cells eGFP‐positive and a limited acute effect on lowering the target cell population. However, the interaction between effector and target (E:T) cells, at a low ratio, lowered the cell membrane integrity, and reduced the M7‐AMkL cell population after 24 h of co‐culture, while the cytotoxic effect was not significant in groups with higher E:T ratio. Our findings suggest that the anti‐CD41 CAR T cells are efficient for a limited time spawn and the cytotoxic effect is visible in all experimental groups with low E:T ratio.
Relationship between CD4+ T‐cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study
Authors: Shintani Tomoaki , Okada Miho , Iwata Tomoyuki , Kawagoe Maiko , Yamasaki Naoya , Inoue Tomoko , Nakanishi Jun , Furutama Daisuke , Takeda Katsuhiro , Ando Toshinori , Nakaoka Miyuki , Mizuno Noriyoshi , Fujii Teruhisa , Kajiya Mikihito , Shiba Hideki 
Published: September 2023

AbstractAimTo retrospectively investigate the relationship between the CD4+ T‐cell counts at baseline and the efficacy of the initial periodontal treatment of patients undergoing treatment for human immunodeficiency virus (HIV) infection using the periodontal inflamed surface area (PISA).Materials and MethodsThirty‐three patients with chronic periodontitis who had undergone periodontal examination at baseline and after the initial periodontal treatment were enrolled. PISA was calculated from the periodontal probing depth and bleeding on probing, and the ratio of PISA after treatment to that at baseline (PISA response ratio) was calculated. Groups with a response ratio of <1 and ≥1 were defined as the improvement and the non‐improvement groups, respectively.ResultsPISA after the initial periodontal treatment significantly decreased compared with that at baseline (p < .05). A weak negative correlation was found between the PISA response ratio and CD4+ T‐cell counts at baseline (p < .05). The CD4+ T‐cell counts at baseline were significantly higher in the improvement group than in the non‐improvement group (p < .05). Multivariate analysis revealed that the CD4+ T‐cell counts at baseline was an independent factor that affects the PISA (p < .05).ConclusionsThe higher the CD4+ T‐cell counts at baseline in patients undergoing treatment for HIV infection, the more effective the initial periodontal treatment.
Why do Hymenopteran workers drift to non-natal groups? Generalized reciprocity and the maximization of group and parental success
Authors: Nonacs Peter 
Published: September 2023

Abstract
Eusocial Hymenoptera are often characterized by having facultatively or obligately sterile worker castes. However, findings across an increasing number of species are that some workers are non-natal—they have ‘drifted’ away from where they were born and raised. Moreover, drifters are often indistinguishable from natal workers in the work and benefits provided to joined groups. This seems an evolutionary paradox of providing benefits to potentially unrelated individuals over close kin. Rather than being mistakes, drifting is proposed to be adaptive if joiners either gain inclusive fitness by preferentially moving to other kin groups or through generalized reciprocity in which exchanging workers across groups raises group-level genetic diversity and creates social heterosis. It is unclear, however, if reciprocity is unlikely because of a susceptibility to cheating. In resolving this question, a series of evolutionary simulations show: (1) Reciprocity can persist under a range of genetic assumptions and scenarios of cheating, (2) cheating almost always evolves, but can be expressed in a variety of ways that are not always predictable, (3) the inclusive fitness hypothesis is equally or more susceptible to cheating. Moreover, existing data in Hymenoptera (although not extensive) are more consistent with generalized reciprocity. This supports a hypothesis that drifting, as a phenomenon, may more often reflect maximization of group and parental fitness rather than fitness gains for the individual drifters.
Abstract
This article examines ‘worker drifting’ across social insect nests, where workers (W) move from their queen's (Q) nest to work for a non-natal group. This could be either kinship driven (left panel) with bias in movement to smaller nests that are genetically related (shown by same color), or generalized reciprocity where workers indiscriminately drift, which increases genetic diversity across all nests. Both processed could be present, by mathematical simulations and field observations are more supportive of generalized reciprocity.
Health care utilization before and after a dementia diagnosis in Medicare Advantage versus traditional Medicare
Authors: Jacobson Mireille , Ferido Patricia , Zissimopoulos Julie 
Published: September 2023

AbstractBackgroundHalf of all Medicare beneficiaries are enrolled in Medicare Advantage (MA). Many studies document lower care utilization and mortality in MA than traditional Medicare (TM), but evidence for persons with Alzheimer's disease and related dementias (ADRD) is limited.MethodsWe conducted a retrospective cohort study of 2015–2018 Medicare claims and encounter data for community‐dwelling beneficiaries aged 65 and over in TM and MA with an incident ADRD diagnosis in 2017. We compared monthly hospitalization rates and outpatient visits 12 months before and after diagnosis and mortality 1 year from diagnosis. Models adjusted for sociodemographic characteristics and comorbidities. Sensitivity analyses addressed residual confounding using a control group with incident arthritis/glaucoma or excluding MA Special Needs Plans, and potential underreporting by restricting to MA plans with high data completeness.ResultsAmong 454,508 beneficiaries diagnosed with ADRD in 2017, 250,837 (55%) were in TM and 203,671 (45%) in MA. Four to 12 months before diagnosis, monthly hospitalizations and outpatient visits were similar in TM and MA. In the diagnosis month, 36.5% of beneficiaries in TM had a hospitalization compared with 25.4% in MA, an adjusted difference of 10.7 percentage points [95% CI: 10.3, 11.1]. Beneficiaries in TM averaged 10.5 outpatient visits in the diagnosis month compared with 8.4 in MA, an adjusted difference of 1.59 visits [95% CI: 1.47–1.70]. Utilization differences narrowed but remained higher in TM for many months. One‐year mortality was 27.9% in TM and 22.2% in MA; an adjusted odds ratio of 1.152 [95% CI: 1.135–1.169] for those in TM compared with MA. Controlling for hospitalization in the diagnosis month substantially reduced the mortality difference.ConclusionHospitalization rates and outpatient visits increased more after an ADRD diagnosis in TM than MA. One‐year post‐diagnosis, mortality was not higher in MA than TM but comparisons of quality of life and caregiver burden are needed.
Amyloid‐β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo‐ and holo‐transferrin
Authors: Baringer Stephanie L. , Lukacher Avraham S. , Palsa Kondaiah , Kim Hyosung , Lippmann Ethan S. , Spiegelman Vladimir S. , Simpson Ian A. , Connor James R. 
Published: September 2023

AbstractExcessive brain iron accumulation is observed early in the onset of Alzheimer's disease, notably prior to widespread proteinopathy. These findings suggest that increases in brain iron levels are due to a dysregulation of the iron transport mechanism at the blood–brain barrier. Astrocytes release signals (apo‐ and holo‐transferrin) that communicate brain iron needs to endothelial cells in order to modulate iron transport. Here we use iPSC‐derived astrocytes and endothelial cells to investigate how early‐disease levels of amyloid‐β disrupt iron transport signals secreted by astrocytes to stimulate iron transport from endothelial cells. We demonstrate that conditioned media from astrocytes treated with amyloid‐β stimulates iron transport from endothelial cells and induces changes in iron transport pathway proteins. The mechanism underlying this response begins with increased iron uptake and mitochondrial activity by the astrocytes, which in turn increases levels of apo‐transferrin in the amyloid‐β conditioned astrocyte media leading to increased iron transport from endothelial cells. These novel findings offer a potential explanation for the initiation of excessive iron accumulation in early stages of Alzheimer's disease. What's more, these data provide the first example of how the mechanism of iron transport regulation by apo‐ and holo‐transferrin becomes misappropriated in disease that can lead to iron accumulation. The clinical benefit from understanding early dysregulation in brain iron transport in AD cannot be understated. If therapeutics can target this early process, they could possibly prevent the detrimental cascade that occurs with excessive iron accumulation.image
The effectiveness of S‐LEC™ solar control film L in laminated glass for reducing the burning sensation caused by near‐infrared radiation
Authors: Shinohara Koji , Nomachi Akira , Kawashima Makoto 
Published: September 2023

AbstractObjectivesThe aim of this study was to examine the potential for S‐LEC™ Solar Control Film L, a heat insulating interlayer film for laminated glass developed by Sekisui Chemical Co., Ltd., to reduce the burning sensation caused by near infrared (NIR) radiation.MethodsA crossover study was performed in 49 male and female subjects, using three different combinations of laminated glass with interlayer films. Subjects placed their right hand under each glass in an NIR irradiation device. The dorsal side of the right hand was irradiated with NIR for 30 s and the onset and degree of a burning sensation was measured.ResultsLaminated glass with S‐LEC™ Solar Control Film L reduced the burning sensation caused by NIR and delayed the onset of the sensation, compared with the control glasses.ConclusionThe use of S‐LEC™ Solar Control Film L in the laminated glass of vehicles may improve passenger comfort and prevent skin disorders such as photoaging caused by prolonged exposure to NIR.
Adverse effect of botulinum toxin‐A injections on mandibular bone: A systematic review and meta‐analysis
Authors: Moussa Mahmoud S. , Bachour Dona , Komarova Svetlana V. 
Published: September 2023

AbstractIntroductionBotulinum toxin‐A (BTX) is a potent neurotoxin that is emerging in the scope of dental practice for its ability to temporarily paralyse musculature and reduce hyperfunction. This may be desirable in diseases/disorders associated with hyperactive muscles such as the muscles of mastication, most implicated in painful temporomandibular disorders (TMDs). The use of BTX extends beyond its indications with off‐label use in TMD's and other conditions, while potential adverse effects remain understudied. BTX is well‐established hindlimb paralysis model in animals leading to significant bone loss with underlying mechanisms remaining unclear. The objective of this study is to systematically review the literature for articles investigating changes in mandibular bone following BTX injections and meta‐analyse available data on reported bone outcomes.MethodsComprehensive search of Medline, Embase and Web of Science retrieved 934 articles. Following the screening process, 36 articles in animals and humans were included for quantitative synthesis. Articles in human individuals (6) and three different animal species (14) presented mandibular bone outcomes that were included in the meta‐analysis.ResultsThe masseter and temporalis muscles were frequently injected across all species. In humans, we observe a decrease of about 6% in cortical thickness of mandibular regions following BTX injection with no evident changes in either volume or density of bone structures. In animals, bone loss in the condylar region is significantly high in both cortical and trabecular compartments.DiscussionOur analysis supports the concept of BTX‐induced bone‐loss model in animal mandibles. Further, bone loss might be confined to the cortical compartments in humans. Most studies did not address the reality of repeated injections and excessive dosing, which occur due to the reversible action of BTX. More rigorous trials are needed to draw a full picture of potential long‐term adverse effects on bone.
Hereditary myotonia in cats associated with a new homozygous missense variant p.Ala331Pro in the muscle chloride channel ClC‐1
Authors: Corrêa Sílvia , Basso Roberta Martins , Cerri Fabricio Moreira , de Oliveira‐Filho José Paes , Araújo João Pessoa , Torelli Sandra Regina , Salán Livia Pinheiro Chagas da Cunha , Salán Maurício Oliveira , Macedo Isabella Zeque , Borges Alexandre Secorun 
Published: September 2023

AbstractThree‐related cats were evaluated for a history of short‐strided gait and temporary recumbency after startle. Neurological examination, electromyography (EMG), muscle biopsies, and a chloride voltage‐gated channel 1 (CLCN1) molecular study were performed. Clinically, all 3 cats presented myotonia with warm‐up phenomenon and myotonic discharges during EMG examination. Muscle biopsies showed normal muscle architecture and variation in the diameter of myofiber size with the presence of numerous hypertrophic fibers. The molecular study revealed a missense variant (c.991G>C, p.Ala331Pro) in exon 9 of the CLCN1 gene, responsible for the first chloride channel extracellular loop. This mutation was screened in 104 control phenotypically normal unrelated cats, and all were wildtype. The alanine at this position is conserved in ClC‐1 (chloride channel protein 1) in different species, and 2 mutations at this amino acid position are associated with human myotonia. This is the third CLCN1 mutation described in the literature associated with hereditary myotonia in cats and the first in domestic animals located in an extracellular muscle ClC‐1 loop.