bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and prognostic analysis of SMARCA4‐deficient non‐small cell lung cancer
Authors: Liang Xiyue , Gao Xianzheng , Wang Feng , Li Shenglei , Zhou Yashu , Guo Peng , Meng Yuanyuan , Lu Taiying 
Published: May 2023

AbstractPurposeTo improve the understanding of special types of tumors, we summarized and analyzed the clinicopathological features and prognostic factors of SMARCA4‐deficient non‐small cell lung cancer (SMARCA4‐dNSCLC).MethodsWe selected 105 patients with SMARCA4‐dNSCLC and 221 patients with SMARCA4‐intact non‐small cell lung cancer (SMARCA4‐iNSCLC) by performing immunohistochemical analysis of 1520 NSCLC samples, and we assessed the patients' clinicopathological features and survival state.Results(1) SMARCA4‐dNSCLC was significantly associated with older age, male sex, smoking history, larger invasive tumor size, higher tumor proliferation index (Ki‐67), more adrenal metastases, more lymph node metastases, and few EGFR mutations (p < 0.05). The tumors were mostly negative for thyroid transcription factor‐1 (TTF‐1), CD34, and p40 and positive for cytokeratin 7 (CK7) in immunohistochemistry (IHC). Nineteen SMARCA4‐dNSCLC patients mostly had TP53, SMARCA4, and LRP1B mutations, and 48% of them had SMARCA4 frameshift mutations. SMARCA4‐dNSCLC patients have a worse prognosis than SMARCA4‐iNSCLC patients (HR: 0.27; 95% CI: 0.17–0.45). The overall survival (OS) of patients with stage III SMARCA4‐dNSCLC was worse than that of patients with SMARCA4‐iNSCLC, and the OS of stage IV SMARCA4‐dNSCLC patients was also worse than that of SMARCA4‐iNSCLC patients (p < 0.01). (2) Multivariate regression analysis showed that sex (HR: 4.12; 95% CI: 1.03–16.39) and smoking history (HR: 2.29; 95% CI: 1.04–5.02) had significant effects on the survival time of SMARCA4‐dNSCLC patients. In SMARCA4‐dNSCLC patients without distant metastases (stage I–III), patients with stage N2 or N3 lymph node metastases (HR: 6.35; 95% CI: 1.07–37.47) had a poor prognosis. Among patients with SMARCA4‐dNSCLC who were treated and had distant metastases (stage IV), male patients and patients treated with immunotherapy combined with chemotherapy showed a longer median overall survival (mOS).ConclusionSMARCA4‐dNSCLC has unique clinicopathological features and a shorter survival prognosis than SMARCA4‐iNSCLC. The efficacy of immunotherapy combined with chemotherapy needs to be observed for longer periods.
Phytochemical Investigation of Cuscuta campestris Yunck. Stem Extract and Evaluation of Its Bioherbicidal Effect on Amaranthus retroflexus L. and Portulaca oleracea L
Authors: Sarić‐Krsmanović Marija , Tojić Teodora , Gajić Umiljendić Jelena , Đorđević Tijana , Đurović‐Pejčev Rada , Radivojević Ljiljana , Božić Dragana , Vrbničanin Sava 
Published: May 2023

AbstractThis study focused on characterizing chemically and evaluating in vitro allelopathic and bioherbicidal potential of secondary metabolites extracted from the stem of Cuscuta campestris in seed germination, early seedling growth and early plant growth of Amaranthus retroflexus and Portulaca oleracea. The combined effects of stem extract and a reduced dose of herbicide metribuzin were also examined. Plant extract contained 17 phenolic compounds and the most abundant phenols were flavonoids: quercetin, (+)‐catechin, daidzin, luteolin, and rutin. The seeds of P. oleracea were less sensitive than the seeds of A. retroflexus. The seed bioassay confirmed the inhibitory effect of stem extract on germination and early growth of both weed seedlings at concentrations of 0.75 % and 1 %, and a minor inhibitory effect in the plant bioassay. On the other hand, a synergy of C. campestris stem extract and metribuzin was revealed, as their combination achieved better results in the control of both weed species. Based on obtained data C. campestris stem extract could be a potential source of natural‐based weed control molecules.
A New Carvotacetone Derivative from the Aerial Part of Sphaeranthus africanus
Authors: Thuy Le Huong , Vu Thien‐Y , Nguyen Tran‐Van‐Anh , Dinh Tri Mai , Pham Nguyen‐Kim‐Tuyen , Truong Nguyen Huy , Nguyen Ngoc‐Hong , Nguyen Huu‐Hung , Duong Thuc‐Huy 
Published: May 2023

AbstractSphaeranthus africanus L. is native in Vietnam. Little is known about α‐glucosidase inhibition of Sphaeranthus africanus and its isolated compounds. A bioactive‐guided isolation was applied to the Vietnamese Sphaeranthus africanus to find α‐glucosidase inhibitory components. Eight compounds were detected and structurally elucidated. They are 3‐angeloyloxy‐5‐[2′′,3′′‐epoxy‐2′′‐methylbutanoyloxy]‐7‐hydroxycarvotacetone, 3‐angeloyloxy‐5‐[3′′‐chloro‐2′′‐hydroxy‐2′′‐methylbutanoyloxy]‐7‐hydroxycarvotacetone, 3‐angeloyloxy‐5‐[2′′R,3′′R‐dihydroxy‐2′′‐methyl‐butanoyloxy]‐7‐hydroxycarvotacetone, 3‐angeloyloxy‐5‐[2′′S,3′′R‐dihydroxy‐2′′‐methylbutanoyloxy]‐7‐hydroxycarvotacetone, 3‐angeloyloxy‐5‐[2′′S,3′′S‐dihydroxy‐2′′‐methylbutanoyloxy]‐7‐hydroxycarvotacetone, 5‐angeloyloxy‐7‐hydroxy‐3‐tigloyloxycarvotacetone, 3‐O‐methylquercetin, and chrysosplenol D. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high‐resolution mass spectroscopy as well as comparisons in literature. 3‐Angeloyloxy‐5‐[2′′S,3′′S‐dihydroxy‐2′′‐methylbutanoyloxy]‐7‐hydroxycarvotacetone is a new compound. Isolated compounds were evaluated for the α‐glucosidase inhibition. Isolated compounds showed moderate activity with IC50 values ranging from 128.9–274.3 μM while others are weak. A molecular docking study was conducted, indicating that isolated compounds are potent α‐glucosidase inhibitory compounds.
Thyrotoxic periodic paralysis as the first presentation of Graves' disease: A case report
Authors: Al‐Mashdali Abdulrahman F. , Alfatih Mohammed , Umer Waseem , Eldeeb Yasser 
Published: May 2023

AbstractThyrotoxic periodic paralysis (TPP) is a rare disease seen predominantly in men of Asian origin. It should be considered in the differential diagnosis of patients with acute onset of weakness, and it is reversible after the correction of serum potassium. TPP can rarely be the initial presentation of Graves' disease.
Lewis Acid‐Catalyzed Ring‐Opening Alcoholysis of Cyclohexene Oxide: The Role of Open Metal Sites in the Bi(III)‐based Metal‐Organic Framework SU‐101
Authors: Obeso Juan L. , Gabriel Flores J. , Flores Catalina V. , Rios‐Escobedo Reyna , Aguilar‐Pliego Julia , Ken Inge A. , Antonio de los Reyes José , Peralta Ricardo A. , Ibarra Ilich A. , Leyva Carolina 
Published: May 2023

AbstractSU‐101 was screened for the acid‐catalyzed ring‐opening alcoholysis of cyclohexene oxide. Results indicated access to open metal sites within SU‐101, a fundamental requirement (Lewis acid Bi+3 sites) for this reaction. In addition, SU‐101 exhibited high chemical stability, demonstrated by retaining its crystalline structure after the reaction. The cyclohexene conversion was estimated to be 99.8, 96.8, and 14.3 % at 40 °C for methanol, ethanol, and propanol, respectively. Also, SU‐101 demonstrated an outstanding catalytic cyclability performance for five cycles without losing catalytic activity.
Visible‐Light‐Responsive Crystalline Solids by Equipping Covalent Organic Frameworks with Donor‐Acceptor Stenhouse Adducts
Authors: Duan Yongli , Sun Fanxi , Gao Ang , Wang Zhen , Xiong Xiaoyu , Mao Lijun , Han Bo , He Chao , Deng Xu , Zheng Yonghao , Wang Dongsheng 
Published: May 2023

Comprehensive SummaryControlling properties of crystalline solids by light remains a challenge because the lack of intrinsic structural flexibility limits the necessary molecular mobility for photoisomerization. In this work, we reported a series of visible‐light‐responsive covalent organic frameworks (COFs) by introducing donor‐acceptor Stenhouse adducts (DASAs) with various electron‐withdrawing moieties via a post‐modified strategy. The DASAs‐functionalized COFs exhibit distorted honeycomb layered topology with long‐range periodicity. The DASAs grafted on the skeletons are pointing into the nanopores of COFs, which weakens intermolecular aggregation and ensures sufficient free volume to undergo reversible isomerization between linear and cyclic states. Furthermore, the crystalline and optical properties of COFs as well as the geometrical size and hydrophilicity inside the nanopores were reversibly controlled by alternating visible light irradiation and heat. Finally, methyl violet was used as the cargo molecules to be immobilized into the nanopores of COFs, which showed fast release under controlling of visible light.
The Arab COVID‐19 Anxiety Syndrome Scale (C‐19ASS): COVID‐19 anxiety syndrome and psychological symptoms in the Saudi Arabian population
Authors: Alhakami Amal , Salem Victoria , Alateeq Deemah , Nikčević Ana V. , Marci Tatiana , Palmieri Sara , Spada Marcantonio M. , Mansueto Giovanni 
Published: May 2023

AbstractIntroductionThe COVID‐19 Anxiety Syndrome Scale (C‐19ASS) is a reliable scale assessing dysfunctional coping strategies activated in response to COVID‐19 fear and threat. The present study aimed to provide a validation of the Arabic version of the C‐19ASS and to explore the association between the C‐19ASS and psychological symptoms syndrome.MethodIn Study 1, a community sample of 404 participants completed the Arabic version of the C‐19ASS and results were subjected to an exploratory factor analysis. In Study 2, a community sample of 903 participants completed the Arabic version of the C‐19ASS and a series of measures assessing depressed mood and anhedonia, generalized anxiety and health anxiety. Internal consistency, construct validity and incremental validity were assessed. Associations between C‐19ASS and psychological symptoms were assessed.ResultsFactor analysis identified a two‐factor solution (i.e., C‐19ASS‐Perseveration and C‐19ASS‐Avoidance), and confirmatory factor analysis suggested a two‐factor model best fits the data. The Arabic version of the C‐19ASS showed good internal consistency, good construct and incremental validity. COVID‐19 anxiety syndrome was associated with more severe anxiety symptoms, depressive symptoms and health anxiety. Females had higher levels of COVID‐19 anxiety syndrome than males. Participants diagnosed with COVID‐19, and those who had experienced loss as a consequence of COVID‐19, had higher levels of COVID‐19 anxiety syndrome (Perseveration).ConclusionsThe Arabic version of the C‐19ASS appears to be a reliable and valid measure of the COVID‐19 anxiety syndrome. The COVID‐19 anxiety syndrome could be a suitable therapeutic target to improve psychological recovery during the COVID‐19 pandemic among Arabs.
Electron‐Donating and Electron‐Withdrawing Subunit Effects on Coumarin‐BODIPY Dyads: Optical and Electrochemical Properties and Molecular Interactions
Authors: Köksoy Baybars , Özdemir Mücahit , Altınışık Sinem , Zorlu Yunus , Yalçın Bahattin , Durmuş Mahmut , Koyuncu Sermet 
Published: May 2023

AbstractIn this study, a series of coumarin‐BODIPY molecules were synthesized using a Sonogashira cross‐linking reaction. The effects of electron withdrawing and electron donating moieties on electrochemical and optical properties were supported by results of density functional theory calculations, and energy transfer mechanisms were investigated. The band gap value decreased from 2.0 eV to 1.6 eV due to reversible oxidation of the extra dimethylamino subunit at lower potential. Besides, characteristics of the crystal structures were investigated with single‐crystal X‐ray diffraction, and crystallinity was supported by differential scanning calorimetry. In addition, when the thin film surface morphologies were examined, it was clearly observed that the N,N‐dimethylamino group on the coumarin‐BODIPY dyad (B3) formed large‐scale domains due to its crystalline behavior. As a result, Förster‐type energy transfer was observed for coumarin‐BODIPY dyads containing different electron withdrawing and donating subunits.
PhAT: A Flexible Open‐Source GUI‐Driven Toolkit for Photometry Analysis
Authors: Murphy Kathleen Z. , Haile Eyobel D. , McTigue Anna D. , Pierce Anne F. , Donaldson Zoe R. 
Published: May 2023

AbstractPhotometry approaches detect sensor‐mediated changes in fluorescence as a proxy for rapid molecular changes within the brain. As a flexible technique with a relatively low cost to implement, photometry is rapidly being incorporated into neuroscience laboratories. Yet, although multiple data acquisition systems for photometry now exist, robust analytical pipelines for the resulting data remain limited. Here we present the Photometry Analysis Toolkit (PhAT)—a free open‐source analysis pipeline that provides options for signal normalization, incorporation of multiple data streams to align photometry data with behavior and other events, calculation of event‐related changes in fluorescence, and comparison of similarity across fluorescent traces. A graphical user interface (GUI) enables use of this software without prior coding knowledge. In addition to providing foundational analytical tools, PhAT is designed to readily incorporate community‐driven development of new modules for more bespoke analyses, and enables data to be easily exported to enable subsequent statistical testing and/or code‐based analyses. In addition, we provide recommendations regarding technical aspects of photometry experiments, including sensor selection and validation, reference signal considerations, and best practices for experimental design and data collection. We hope that the distribution of this software and protocols will lower the barrier to entry for new photometry users and improve the quality of collected data, increasing transparency and reproducibility in photometry analyses. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Software and environment installationAlternate Protocol 1: Software and environment updateBasic Protocol 2: GUI‐driven fiber photometry analysisSupport Protocol 1: Examining signal qualitySupport Protocol 2: Interacting with graphsBasic Protocol 3: Adding modules to PhATAlternate Protocol 2: Creating functions for use in Jupyter Notebook
Improved Low‐Temperature Hydrogen Production from Aqueous Methanol Based on Synergism between Cationic Pt and Interfacial Basic LaOx
Authors: Mori Kohsuke , Shimoji Yuki , Yamashita Hiromi 
Published: May 2023

AbstractAqueous phase reforming of methanol (APRM) is simple, inexpensive and provides a high hydrogen gravimetric density of 18.8 wt. %, and so is superior to traditional gas‐phase reactions performed at relatively high temperatures. In the present work, the interface between Pt nanoparticles and a TiN support was modified using a highly dispersed amorphous LaOx phase. The resulting Pt/LaOx/TiO(N) exhibited enhanced activity and long‐term stability during the APRM reaction under base‐free conditions compared with Pt catalysts supported on unmodified TiN or crystalline La2O3. The interfacial amorphous LaOx phase promoted the deposition of small Pt nanoparticles having a narrow size distribution, and also generated electron‐deficient Pt. An assessment of kinetic isotope data and theoretical investigations demonstrated that the cationic Pt nanoparticles facilitated the cleavage of O−H and C−H bonds in methanol while the amorphous LaOx enhanced the dissociation of water, thus enabling the water‐gas shift reaction under mild conditions.
Process Development of Heterogeneous Rh Catalyzed Carbene Transfer Reactions Under Continuous Flow Conditions
Authors: Bayrakdar Tahani A. C. A. , Lescot Camille 
Published: May 2023

AbstractA very simple Rh‐based catalyst operates under heterogeneous flow conditions for the carbene transfer of methyl diazoacetate (MDA) with several substrates. Two different methods for heterogenizing the catalyst in a column reactor have been applied. Different X−H (X=O, S, Si, CH2) were successfully functionalized by the carbene and cyclopropenation was performed under very mild continuous flow conditions. Following these promising results, catalyst recycling experiments using both methodologies were conducted in which up to 5 catalytic cycles have been achieved for the carbene O−H insertion reaction and interestingly, a sequential transformation of different substrates with up to 10 consecutive runs per reactor were achieved with no loss in the catalytic activity, thus allowing the production of families of compounds.
Design of SEU and DNU‐resistant SRAM cells based on polarity reinforcement feature
Authors: Bai Na , Chen Zihan , Xu Yaohua , Wang Yi , Zhou Yueliang , Lin Zeyuan 
Published: May 2023

SummaryAs the scale of the integrated circuit increases, the distance between transistors decreases, a trend that reduces the critical charge of the sensitive nodes of the memory cell. Consequently, Static Random Access Memory cells in high radiation environments are very prone to soft errors. A novel radiation‐hardened memory cell, the Polarity Reinforcement Feature (PRF)‐18T, is proposed in this paper, which uses the polarity reinforcement feature to reduce the number of sensitive nodes in the memory cell and can entirely and effectively tolerate single event upset and double node upset. A comparison is made in this paper with DICE‐12T, Quatro‐10T, SEA‐14T, RHBD‐14T, NASA‐13T, and SCCS‐18T memory cells in a simulation environment with Semiconductor Manufacturing International Corporation 55 nm process, the supply voltage of 1.2 V, and temperature of 25°C. In comparison, the PRF‐18T proposed in this paper has the highest critical charge value, improving by more than 15× and 3.1× compared to the DICE‐12T and RHBD‐14T, respectively, and by more than 79% and 17.6% compared to the Quatro‐10T and SEA‐14T, respectively. In the high hold static noise margin comparison, the improvement over the SEA‐14T, DICE‐12T, RHBD‐14T, and Quatro‐10T is 26.7%, 3.8×, 1.5×, and 1.2×, respectively. In the write static noise margin comparison, the results were similar to the Quatro‐10T, DICE‐12T, and SEA‐14T, with a 68.5% improvement compared to the RHBD‐14T. Finally, the robustness of the proposed cell to process, voltage, and temperature variations is verified by temperature change experiments and 2000 Monte Carlo model simulations.
Integrating multiple sign types to improve occupancy estimation for inconspicuous species
Authors: Goldman Mia R. , Shinderman Matthew , Jeffress Mackenzie R. , Rodhouse Thomas J. , Shoemaker Kevin T. 
Published: May 2023

AbstractStandard occupancy models enable unbiased estimation of occupancy by accounting for observation errors such as missed detections (false negatives) and, less commonly, incorrect detections (false positives). Occupancy models are fitted to data from repeated site visits in which surveyors record evidence of species presence. Use of indirect sign (e.g., scat, tracks) as evidence of presence can vastly improve survey efficiency for inconspicuous species but can also introduce additional sources of error. We developed a “multi‐sign” occupancy approach to model the detection process separately for unique sign types and used this method to improve estimates of occupancy dynamics for an inconspicuous species, the American pika (Ochotona princeps). We investigated how estimates of pika occupancy and environmental drivers differed under four increasingly realistic representations of the observation process: (1) perfect detection (commonly assumed for modeling pika occupancy), (2) standard occupancy model (single observation process without possibility of false detection), (3) multi‐sign with no false detections (non‐false positive model), and (4) multi‐sign with false detections (full model). For the multi‐sign occupancy models, we modeled the detection of each sign type (fresh scat, fresh haypiles, pika calls, and pika sightings) separately as a function of climatic and environmental covariates. Estimates of occupancy processes and inferences about environmental drivers were sensitive to different detection models. Simplified representations of the detection processes generally resulted in higher occupancy estimates and higher turnover rates than the full multi‐sign model. Environmental drivers also varied in their influence on occupancy models, where (e.g.) forb cover was estimated to more strongly influence occupancy in the full multi‐sign model than the simpler models. As has been reported previously in other contexts, unmodeled heterogeneity in the observation process can lead to biases in occupancy processes and uncertainty in the relationships between occupancy and environmental covariates. Overall, our multi‐sign approach to dynamic occupancy modeling, which accounts for spatio‐temporal variation in reliability among sign types, has strong potential to generate more realistic estimates of occupancy dynamics for inconspicuous species.
Potential distribution of the spring ephemeral plant Adonis amurensis in Northeast China under future climate change
Authors: Wang Yanlin , Liu Huanchu , Yu Shuai , Huang Yanqing , Zhang Yue , He Xingyuan , Chen Wei 
Published: May 2023

AbstractAdonis amurensis Regel et Radde is an early spring plant in northeastern China that has great ornamental value because it blooms before other plants have sprouted. It has not been used to its full potential due to environmental restrictions on its growth. It will be extremely important for its application to comprehend the possible habitat of A. amurensis and the critical environmental factors controlling its distribution under current and future climatic scenarios. In this work, two climate change scenarios of 2041–2060 and 2081–2100 were utilized to predict the suitable habitat of A. amurensis. The results showed that the suitable habitat was mainly distributed along the Changbai Mountains, with a total area of 303,090 km2, and the potential and high‐potential habitat area were 141,218 and 161,872 km2, respectively. In the future climate scenarios, the suitable habitat of A. amurensis was still distributed along the Changbai Mountains, but the area was reduced. In ssp126 and ssp585 scenarios of 2041–2060 and 2081–2100, the area was reduced by 7.13% and 22.34% and 18.66% and 8.09%, respectively. The reduced suitable habitat was mainly located in central Heilongjiang (southeastern Xiao Xing'an Ling), central Jilin, and northeastern Liaoning. The suitable habitat was significantly influenced by precipitation, mainly affected by annual precipitation, followed by precipitation seasonality, soil surface pH, and slope. The results of this study can serve as empirical support for the artificial cultivation, ecological restoration, and long‐term use of A. amurensis.