bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new efficient approach for the calculation of cross-sections with application to Yukawa potential
Authors: Lin Chengliang , He Bin , Wu Yong , Wang Jianguo 
Published: March 2023

Abstract
Large-scale and systematic calculations of scattering amplitudes and cross-sections for charged particle collisions are of fundamental importance for understanding the physical properties of materials in different research fields. However, the elaborated theoretical methods for cross-sections are generally restricted to a finite range of impact energies. Here, we present an efficient approach for the calculation of the scattering amplitude and cross-sections ranging from low to high collision energies based on the variable phase method, where the Wentzel–Kramers–Brillouin and Born approximations for scattering phase shifts (SPSs) are incorporated into the numerical algorithm to alleviate the computational cost. For this purpose, quantitative criteria for the validity of these approximations are established based on the properties of the turning points of the potentials. For different scattering potentials, the corresponding planes can be established as a guideline to select the optimal combination for calculating the scattering amplitude and cross-section. The demand for quantum treatment of phase shifts is reduced by one to two orders of magnitude, which strongly benefits the computation of cross-sections for high-energy scattering. It has been found that the quantum treatment for SPSs is necessary near the quantum states involving quantum tunneling and resonance. To testify the validity of the approach, the SPSs and also transport cross-sections are calculated for Yukawa potentials, and good agreements are obtained in comparison with other available high-precision calculations. The proposed numerical approach can be straightforwardly generalized to other scattering potentials and permits one to efficiently calculate the scattering cross-sections for a large energy range.
A reconfigurable and automatic platform for the on-demand production of stretchable conductive composites
Authors: Lu Hongda , Zhang Qingtian , Huang Xumin , Cole Tim , Yun Guolin , Zhang Yuxin , Qiao Ruirui , Li Weihua , Tang Shi-Yang 
Published: March 2023

Abstract
Stretchable conductive composites (SCCs) have been widely used as interconnects and sensors in stretchable electronic devices due to their tunable electromechanical properties and intrinsically high stretchability compared to solid metals. SCCs can be readily made by mixing (or breaking bulk) conductive fillers within an elastomeric polymer, which are subsequently cured. Despite the simplicity of this, most fabrication methods follow customized protocols and lack precise automatic control. These methods also require bulky and costly equipment (e.g. stirrers, mixers, ovens, and vacuuming machines). Also, variations in the production process make it challenging to maintain the consistency of SCC’s electrical and mechanical properties produced in different batches. To solve this problem, this work develops an automatic SCC production platform (ASPP) that can be programmed to produce SCCs with high consistency in properties. The versatility of ASPP is demonstrated by fabricating SCCs with single and hybrid fillers, and porous structures. The consistency of SCCs’ electromechanical properties is examined using samples fabricated in different batches following the same protocol. We further utilize the fabricated SCCs to realize various intelligent tactile sensing and heating platforms. The capability demonstrated for the ASPP shows its potential in fabricating SCCs for applications in soft robotics and wearable devices.
Effects of strong spin-orbit coupling on Shiba states from magnetic adatoms using first-principles theory
Authors: Park Kyungwha , Nyari Bendeguz , Laszloffy Andras , Szunyogh Laszlo , Ujfalussy Balazs 
Published: March 2023

Abstract
Magnetic impurities at surfaces of superconductors can induce bound states referred to as Yu–Shiba–Rusinov states (i.e. Shiba states) within superconducting (SC) gaps. For superconductors with strong spin–orbit coupling (SOC), Shiba states arising from even single magnetic adatoms are too complex to be fully understood using effective models alone because SOC cannot be treated perturbatively and multiple orbitals are strongly mixed with spin projections. Here we investigate Shiba states of single magnetic adatoms at the surface of strongly spin-orbit coupled SC Pb, by solving the fully relativistic Dirac–Bogoliubov–de Gennes equations using multiple scattering Green’s function methods. For Fe and Co adatoms on Pb(110), we show that the Shiba states are better characterized by total angular momentum, J, and its projections on the z axis, m

J
. As a hallmark of the SOC effect, the Shiba states show a strong dependence of the orientation of the adatom moment. As the orientation of the Fe/Co moment changes, the deepest Shiba states merge at zero energy. This zero-energy state disappears with an additional non-magnetic adatom next to the magnetic adatom, although the other Shiba states unchange. For a Mn adatom on Pb, our Shiba states overall agree with experiments. The characteristics of our Shiba states are also observed with the similar energies and characters in the experiments. The deepest Shiba states that we compute, however, do not appear as close to the Fermi level as the experimental data. It would be interesting to compute the Shiba states with continuously varying vertical distances of the Mn adatom from the surface or with varying the charge state of the adatom, and to calculate the spatial dependence of the spectral density. Our findings will be also useful for understanding of Shiba states for dimers and longer spin chains on the Pb surface considering noncollinear magnetic structures in them.
Redefining Beauty: A Qualitative Study Exploring Adult Women's Motivations for Lip Filler Resulting in Anatomical Distortion
Authors: Love Madeleine , Saunders Chloe , Harris Steven , Moon Zoe , Veale David 
Published: March 2023

Abstract

Background
Lip filler enhancement has fast become one of the most popular minimally invasive cosmetic procedures. Motivations for “overtreatment” with lip fillers are poorly understood.

Objectives
The aim of this study was to explore female motivations for and experiences of procedures that achieve an aesthetic of distorted lip anatomy.

Methods
Twenty-four females who had undergone lip filler procedures resulting in strikingly distorted lip anatomy, determined by the Harris classification of filler spread, took part in semistructured interviews about their motivations, experiences, and perceptions related to lip fillers. A qualitative thematic analysis was carried out.

Results
Four major themes are discussed: (1) the normalization of lip fillers, (2) perceptual drift which is mediated by exposure to repetitive images of larger lips on social media, (3) perceived financial and social benefits of larger lips, and (4) the relation between mental health and seeking repeated lip filler procedures.

Conclusions
Motivations for seeking lip fillers vary, but most subjects described social media impacting perceived aesthetic norms. A process of perceptual drift occurs whereby mental schema encoding expectations of “natural” facial anatomy can adapt through repeated exposure to enhanced images. The results can inform aesthetic practitioners and policymakers seeking to understand and support those seeking minimally invasive cosmetic procedures.
The influence of the microbiome on aggressive behavior: an insight into age-related aggression
Authors: Gulledge Laura , Oyebode Damilola , Donaldson Janet R 
Published: March 2023

AbstractAggression is a complex psychological program that is influenced by genetics, environment, and psychological history. Research has shown that the hormonal levels in the body and the development of the brain can be major predictors of aggression. This review highlights recent studies that have connected the gut microbiome to alterations in hormones and brain development and how this can impact aggression. This paper also provides a systematic review on studies that directly assess the connection between the gut microbiome and aggression and reviews these connections in relation to age. We conclude with future directions that are needed to further determine the link between the microbiome and aggression among adolescents.
How to think about and do successful research What you probable did not learn when you first entered the laboratory
Authors: Cooper Terrance G 
Published: March 2023

AbstractThere is a logic to doing successful research, but graduate students and indeed postdoctoral fellows and young independent investigators often learn it apprentice style, by experience. The purpose of this essay is to provide the product of that experience and advice that I have found useful to young researchers as they begin their training and careers.
Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency
Authors: Yau Winifred W , Chen Gao Bin , Zhou Jin , Francisco Joel Celio , Thimmukonda Nivetha Kanakaram , Li Shang , Singh Brijesh Kumar , Yen Paul Michael 
Published: March 2023

Abstract
Citrin deficiency (CD) is an inborn error of metabolism caused by loss-of-function of the mitochondrial aspartate/glutamate transporter, CITRIN, which is involved in both the urea cycle and malate–aspartate shuttle. Patients with CD develop hepatosteatosis and hyperammonemia but there is no effective therapy for CD. Currently, there are no animal models that faithfully recapitulate the human CD phenotype. Accordingly, we generated a CITRIN knockout HepG2 cell line using Clustered Regularly Interspaced Short Palindromic Repeats/Cas 9 genome editing technology to study metabolic and cell signaling defects in CD. CITRIN KO cells showed increased ammonia accumulation, higher cytosolic ratio of reduced versus oxidized form of nicotinamide adenine dinucleotide (NAD) and reduced glycolysis. Surprisingly, these cells showed impaired fatty acid metabolism and mitochondrial activity. CITRIN KO cells also displayed increased cholesterol and bile acid metabolism resembling those observed in CD patients. Remarkably, normalizing cytosolic NADH:NAD+ ratio by nicotinamide riboside increased glycolysis and fatty acid oxidation but had no effect on the hyperammonemia suggesting the urea cycle defect was independent of the aspartate/malate shuttle defect of CD. The correction of glycolysis and fatty acid metabolism defects in CITRIN KO cells by reducing cytoplasmic NADH:NAD+ levels suggests this may be a novel strategy to treat some of the metabolic defects of CD and other mitochondrial diseases.
‘Hindu civilization’ in business: the World Hindu Economic Forum's intellectual project
Authors: Nartok Esra Elif 
Published: March 2023

Abstract
Scholarly debates on ‘civilization states’ now include India as a potential exemplar, in light of the Bharatiya Janata Party's (BJP) insistence on a greater Hindu culture and tradition rooted in ancient India. Most of these debates are located in politico-cultural contexts, whereas this article does something different. It examines an economic organization, the World Hindu Economic Forum (WHEF), which centres its business strategy and identity around the rhetoric of civilization. WHEF is a distinctive and understudied transnational elite platform that has organic connections with the BJP and Hindu nationalist circles around the world. Drawing on WHEF documentation and interviews with WHEF members, and employing a Gramscian approach, this article sheds light on three social aspects of utilizing the civilizational rhetoric in WHEF's business strategy: a justification of development rooted in the past, a claim of superiority over the West, and a promise of development for the future. It argues that all three aspects make up a particular elite conception of the world shaped around the WHEF members' ideological and material interests. Based on this elite agency, this article argues that the rhetoric of civilization is a product of today's existing global political economy and ultimately serves to reinforce Hindu nationalist sentiments along with neo-liberal market-oriented ideas.
India's civilizational arguments in south Asia: from Nehruvianism to Hindutva
Authors: Chatterjee Shibashis , Das Udayan 
Published: March 2023

Abstract
India has used civilizational discourses as part of its foreign policy to articulate its rise and rightful place in the world order. This article primarily examines India's civilizational arguments in south Asia. India's civilizational arguments in the region demand scrutiny as the neighbourhood is a theatre of contestation between territorial India and the claims of its civilizational space. Analysing historical accounts on Indian civilization, official documents and domestic narratives in India about south Asia, the article makes three points. First, India's civilizational articulation oscillates between two paradigmatic and contrasting representations of Nehruvianism and Hindutva variants. Second, it is argued that despite the ascendancy of Hindutva's civilizational symbolism since 2014, India's south Asia policy shows no paradigmatic change. Finally, it points to how the Hindutva project may be detrimental to India's self-image and dealings in south Asia. The article argues that while there is no official corroboration of Hindutva's claims in India's south Asia policy, the increasing salience of the domestic discussions around Akhand Bharat (undivided India) invites complications for India in its neighbourhood. India's Hindutva-driven civilizational claims raise anxieties of an Indian cultural hegemony in an asymmetric region splintered across territorial and nationalistic lines.
The narratives and aesthetics of the civilizational state in the ‘new’ India
Authors: Srivastava Jayati 
Published: March 2023

Abstract
The term ‘civilizational state’ is used by emerging powers, including India, to mark themselves as distinct from the Westphalian states. This article addresses the following questions: why does India invoke this term despite its association with illiberal states? What ideological foundations and resources inform this narrative? And how does the ‘new’ India envision its role in international politics? Using an interpretive analysis of select texts and imagery, the article delineates the intellectual roots and aesthetic resources deployed by ‘new’ India to bring forth a civilizational state narrative which has become an important tool of power projection at both domestic and international levels. It argues that the recent shift from ‘civilization’ to ‘civilizational state’ draws its intellectual roots from early Hindutva idealogues. It is based on a conflict-ridden/homogenous understanding of civilization, making it ambivalent towards an inclusive/plural civilizational narrative articulated and nurtured by the nationalists. Internationally, the civilizational state narrative is geared towards reinforcing ‘new’ India's claim to be in the league of great powers; projecting itself as a power with a difference. Being the world's largest democracy helps in reinforcing this narrative, but signs of a shift towards a homogenous civilizational narrative will have wider implications for India's role in international politics.
Oral delivery of brain-targeted miltefosine-loaded alginate nanoparticles functionalized with polysorbate 80 for the treatment of cryptococcal meningitis
Authors: Spadari Cristina C , Lanser Dylan M , Araújo Marcelo V , De Jesus Daniel F F , Lopes Luciana B , Gelli Angie , Ishida Kelly 
Published: March 2023

Abstract

Objectives
To develop alginate nanoparticles functionalized with polysorbate 80 (P80) as miltefosine carriers for brain targeting in the oral treatment of cryptococcal meningitis.

Methods
Miltefosine-loaded alginate nanoparticles functionalized or not with P80 were produced by an emulsification/external gelation method and the physicochemical characteristics were determined. The haemolytic activity and cytotoxic and antifungal effects of nanoparticles were assessed in an in vitro model of the blood–brain barrier (BBB). A murine model of disseminated cryptococcosis was used for testing the efficacy of oral treatment with the nanoparticles. In addition, serum biomarkers were measured for toxicity evaluation and the nanoparticle biodistribution was analysed.

Results
P80-functionalized nanoparticles had a mean size of ∼300 nm, a polydispersity index of ∼0.4 and zeta potential around −50 mV, and they promoted a sustained drug release. Both nanoparticles were effective in decreasing the infection process across the BBB model and reduced drug cytotoxicity and haemolysis. In in vivo cryptococcosis, the oral treatment with two doses of P80 nanoparticles reduced the fungal burden in the brain and lungs, while the non-functionalized nanoparticles reduced fungal amount only in the lungs, and the free miltefosine was not effective. In addition, the P80-functionalization improved the nanoparticle distribution in several organs, especially in the brain. Finally, treatment with nanoparticles did not cause any toxicity in animals.

Conclusions
These results support the potential use of P80-functionalized alginate nanoparticles as miltefosine carriers for non-toxic and effective alternative oral treatment, enabling BBB translocation and reduction of fungal infection in the brain.
A10 OVEREXPRESSION OF ASCL2 ALTERS DIFFERENTIATION, CELL CYCLE AND RESISTANCE TO ANTI-CANCER TREATMENT IN ESOPHAGEAL ORGANOIDS
Authors: Hamilton M , Mars Z , Sedeuil M , Rolland M , Jean D , Giroux V 
Published: March 2023

Abstract

Background
The esophagus is in constant contact with the austere environment caused by food and gastric reflux. It is protected by a squamous epithelium which maintenance is provided by a rare subpopulation of basal cells: Keratin 15+ (Krt15+) stem cells. However, little is known about the mechanisms underlying the expansion and the function of these stem cells. It was shown that the transcription factor ASCL2 is strongly upregulated in Krt15+ cells compared to Krt15- cells. Interestingly, ASCL2 is a gene target of the Wnt/β-catenin pathway, which acts as a regulator of proliferation and maintenance of the stemness state.

Purpose
The ultimate goal of my research project is to determine the role of ASCL2 in the maintenance of esophageal stem cells. To do so, I will investigate the role of ASCL2 in esophageal epithelial biology.

Method
Lentiviral infection approach was used to obtain mouse esophageal organoids overexpressing ASCL2 (ASCL2OE). Organoid culture, immunostaining (such as IF and H&E), qPCR, WB, mass spectrometry and proliferation assay were used to characterize the effect of ASCL2OE on morphology, differentiation, proliferation, self-renewal, and gene expression.

Result(s)
ASCL2OE severely altered the morphology of organoids, which were smaller and less differentiated. Defects in differentiation was investigated by IF which showed that some cells expressed both p63 and K13, respectively basal and suprabasal markers. Thus, cells seem to be blocked in an intermediate state of differentiation suggesting a default in cell fate decision. Mass spectrometry analysis confirmed a change in biological processes related to differentiation of keratinocytes and of epithelial cells. We also investigated the role of ASCL2 in self-renewal and observed that organoid formation rate (OFR) was reduced in ASCL2OE organoids. Furthermore, proliferation was also reduced in WST-1 and EdU assays. We then observed significant changes in the cell cycle by flow cytometry: there is an increased in the number of cells in G0/G1 and a major decrease in G2/M cells, suggesting a blockade in G1. Interestingly, CDNK2a (p16INK4a), an inhibitor of cell cycle progression, was increased in our mass spectrometry results. Finally, ASCL2 could also play a role in radio and chemoresistance of Krt15+ stem cells, as ASCL2OE organoids are less sensitive to radiation and chemotherapy agents than control.

Conclusion(s)
ASCL2 could play a role in orchestrating cell fate decision in the esophageal epithelium as ASCL2OE organoids showed alteration in differentiation, proliferation, and cell cycle.

Please acknowledge all funding agencies by checking the applicable boxes below
Other

Please indicate your source of funding;
NSERC, Canada Research Chairs and CRCHUS scolarship

Disclosure of Interest
None Declared
A28 TIME-RESTRICTED FEEDING REDUCES INFLAMMATORY BOWEL DISEASE AND IMPROVES EPITHELIUM COLON REGENERATION
Authors: Carmona Alcocer V , Taleb Z , Todorovski A , Macdonald J , Igbokwe T , Karpowicz P 
Published: March 2023

Abstract

Background
The circadian clock is a time keeping mechanism that drives daily rhythms in the body, including behavior and gastrointestinal digestion, inflammation, and metabolism. These daily rhythms are endogenous to cells, and they must adjust themselves to cyclic environmental cues like feeding schedules and light dark cycles. However, when the cyclical environment is chrono-disrupted (ex. shiftwork and jetlag), the temporal organization in the body is lost. Chrono-disruption is linked to an increase in the risk of Inflammatory Bowel Disease (IBD); studies in rodents shown that IBD is more severe in mice without a circadian clock and intestinal regeneration is compromised

Purpose
Recent studies have shown that time-restricted feeding (TRF, the provision of food at times of peak behavior activity – without caloric restriction), that aligns with circadian behavior improves daily organization in the body and health. Therefore, we hypothesized that time-restricted feeding would be an effective strategy to ameliorate IBD and improve regeneration in chrono-disrupted animals.

Method
To test this, we used the DSS induction of colitis in mutant mice without clock function (Bmal1-/-) and controls with an intact clock (Bmal1+/+) and compared ad libitum feeding vs. TRF conditions (food available from 7pm to 7am).

Result(s)
Our results show that TRF ameliorates IBD symptoms and protects against epithelium colon damage in animals without clock function. Our preliminary results suggest that TRF may function by increasing the expression of the anti-inflammatory signal PPARg in the colon. Currently, we are testing if the circadian clock controls the daily expression of PPARg in vivo and in vitro. To further test the effect of TRF during regeneration after colitis, we tested proliferation (Ki67) and regeneration in the colon. (Hopx). Our results show that TRF increases the number of Ki67 positive cells and the expression of fetal-like regenerative precursor Hopx in both animals with and without a functional clock.

Conclusion(s)
Together these data suggest that TRF enhances regeneration in the colon after colitis. Moving forward, we are testing transcriptional pathways that are activated during regeneration in animals under TRF. Our results show that time restricted feeding can ameliorate IBD and highlight the role of circadian rhythms in regeneration and intestinal stem cell biology.

Please acknowledge all funding agencies by checking the applicable boxes below
CIHR, Other

Please indicate your source of funding;
Crohn's and Colitis Canada

Disclosure of Interest
None Declared