bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness toward psychosocial support during cancer treatment: a critical yet challenging construct in psychosocial care
Authors: Parmet Tamar , Yusufov Miryam , Braun Ilana M , Pirl William F , Matlock Daniel D , Sannes Timothy S 
Published: March 2023

Abstract
Psychosocial distress screening, mandated by the American College Surgeons’ Commission on Cancer, continues to be implemented across cancer centers nationwide. Although measuring distress is critical to identifying patients who may benefit from additional support, several studies suggest that distress screening may not actually increase patients’ utilization of psychosocial services. While various investigators have identified barriers that may impede effective implementation of distress screening, we posit that patients’ intrinsic motivation, which we term patients’ willingness, may be the biggest predictor for whether cancer patients choose to engage with psychosocial services. In this commentary, we define patient willingness towards psychosocial services as a novel construct, distinct from the intention toward a certain behavior described across pre-existing models of health behavior change. Further, we offer a critical perspective of models of intervention design that focus on acceptability and feasibility as preliminary outcomes thought to encompass the willingness construct described herein. Finally, we summarize several health service models that successfully integrate psychosocial services alongside routine oncology care. Overall, we present an innovative model that acknowledges barriers and facilitators and underscores the critical role of willingness in health behavior change. Consideration of patients’ willingness toward psychosocial care will move the field of psychosocial oncology forward in clinical practice, policy initiatives, and study design.
Implementation planning for equitable tobacco treatment services: a mixed methods assessment of contextual facilitators and barriers in a large comprehensive cancer center
Authors: Tsui Jennifer , Sloan Kylie , Sheth Rajiv , Ewusi Boisvert Esthelle , Nieva Jorge , Kim Anthony W , Pang Raina D , Sussman Steve , Kirkpatrick Matthew 
Published: March 2023

Abstract
Tobacco use among cancer patients is associated with an increased mortality and poorer outcomes, yet two-thirds of patients continue using following diagnosis, with disproportionately higher use among racial/ethnic minority and low socioeconomic status patients. Tobacco treatment services that are effectively tailored and adapted to population characteristics and multilevel context specific to settings serving diverse patients are needed to improve tobacco cessation among cancer patients. We examined tobacco use screening and implementation needs for tobacco treatment services to inform equitable and accessible delivery within a large comprehensive cancer center in the greater Los Angeles region.
We conducted a multi-modal, mixed methods assessment using electronic medical records (EMR), and clinic stakeholder surveys and interviews (guided by the Consolidated Framework for Implementation Research).
Approximately 45% of patients (n = 11,827 of 26,030 total) had missing tobacco use history in their EMR. Several demographic characteristics (gender, age, race/ethnicity, insurance) were associated with greater missing data prevalence. In surveys (n = 32), clinic stakeholders endorsed tobacco screening and cessation services, but indicated necessary improvements for screening/referral procedures. During interviews (n = 13), providers/staff reported tobacco screening was important, but level of priority differed as well as how often and who should screen. Several barriers were noted, including patients’ language/cultural barriers, limited time during visits, lack of smoking cessation training, and insurance coverage.
While stakeholders indicated high interest in tobacco use assessment and cessation services, EMR and interview data revealed opportunities to improve tobacco use screening across patient groups. Implementing sustainable system-level tobacco cessation programs at institutions requires leadership support, staff training, on routine screening, and intervention and referral strategies that meet patients’ linguistic/cultural needs.
Equity and behavioral digital health interventions: Strategies to improve benefit and reach
Authors: Miller Sarah J , Sly Jamilia R , Alcaraz Kassandra I , Ashing Kimlin , Christy Shannon M , Gonzalez Brian , Lu Qian , Newton Robert L , Redmond Michelle , Shen Megan , Thomas-Purcell Kamilah , Yi Jean , Veinot Tiffany , Meade Cathy D 
Published: March 2023

Abstract

Background
Behavioral digital health interventions (e.g., mobile apps, websites, wearables) have been applied widely to improve health outcomes. However, many groups (e.g., people with low income levels, people who are geographically isolated, older adults) may face obstacles to technology access and use. In addition, research has found that biases and stereotypes can be embedded within digital health interventions. As such, behavioral digital health interventions that intend to improve overall population health may unintentionally widen health-related inequities.

Purpose
This commentary offers guidance and strategies to mitigate these risks when using technology as a means for delivering a behavioral health intervention.

Methods
A collaborative working group from Society of Behavioral Medicine’s Health Equity Special Interest Group developed a framework to center equity in the development, testing and dissemination of behavioral digital health interventions.

Results
We introduce Partner, Identify, Demonstrate, Access, Report (PIDAR), a 5-point framework to avoid the creation, perpetuation, and/or widening of health inequities in behavioral digital health work.

Conclusions
It is critically important to prioritize equity when conducting digital health research. The PIDAR framework can serve as a guide for behavioral scientists, clinicians and developers.
Air sac attachments or tendon scars: the distinction between soft tissue traces in archosaur bone
Authors: Aureliano Tito , Ghilardi Aline M , Fernandes Marcelo A , Ricardi-Branco Fresia S 
Published: March 2023

Abstract
It can be arduous to discriminate between lamellar bone fibres, Sharpey’s fibres (tendon insertions) and the pneumosteum (air sac diverticula interaction with the bone) during histological observations. We analysed thin sections of several avemetatarsalians from the Cretaceous of Brazil and used characters from optical mineralogy to differentiate these biomineralized tissue types, resulting in a solid criterion for histological comparison. The observation scale is one of the best guides to differentiate the tissues. Lamellar bone fibres are only perceptible at very high magnifications (100×) whereas Sharpey’s fibres are detectable at low magnification (5×). Pneumosteal bone fibres are discernible at 40–50×. Hence, fibre length is longer in Sharpey’s fibres than in the pneumosteum. High optical relief is a good proxy to detect connective tissue insertion scars (Sharpey’s fibres). Finally, texture is an excellent proxy to identify pneumosteal bone. The asbestiform aspect of this structure is so far unique among several bone tissue types.
What Can Be Learned by a Synoptic Review of Plant Disease Epidemics and Outbreaks Published in 2021?
Authors: Jeger Michael J. , Fielder Hannah , Beale Tim , Szyniszewska Anna M. , Parnell Stephen , Cunniffe Nik J. 
Published: March 2023

A synoptic review of plant disease epidemics and outbreaks was made using two complementary approaches. The first approach involved reviewing scientific literature published in 2021, in which quantitative data related to new plant disease epidemics or outbreaks were obtained via surveys or similar methodologies. The second approach involved retrieving new records added in 2021 to the CABI Distribution Database, which contains over a million global geographic records of organisms from over 50,000 species. The literature review retrieved 186 articles, describing studies in 62 categories (pathogen species/species complexes) across more than 40 host species on six continents. Pathogen species with more than five articles were Bursaphelenchus xylophilus, ‘ Candidatus Liberibacter asiaticus’, cassava mosaic viruses, citrus tristeza virus, Erwinia amylovora, Fusarium spp. complexes, F. oxysporum f. sp. cubense, Magnaporthe oryzae, maize lethal necrosis co-infecting viruses , Meloidogyne spp. complexes, Pseudomonas syringae pvs., Puccinia striiformis f. sp. tritici, Xylella fastidiosa, and Zymoseptoria tritici. Automated searches of the CABI Distribution Database identified 617 distribution records new in 2021 of 283 plant pathogens. A further manual review of these records confirmed 15 pathogens reported in new locations: apple hammerhead viroid, apple rubbery wood viruses, Aphelenchoides besseyi, Biscogniauxia mediterranea, ‘ Ca. Liberibacter asiaticus’, citrus tristeza virus, Colletotrichum siamense, cucurbit chlorotic yellows virus, Erwinia rhapontici, Erysiphe corylacearum, F. oxysporum f. sp. cubense Tropical race 4, Globodera rostochiensis, Nothophoma quercina, potato spindle tuber viroid, and tomato brown rugose fruit virus. Of these, four pathogens had at least 25% of all records reported in 2021. We assessed two of these pathogens—tomato brown rugose fruit virus and cucurbit chlorotic yellows virus—to be actively emerging in/spreading to new locations. Although three important pathogens—‘ Ca. Liberibacter asiaticus’, citrus tristeza virus, and F. oxysporum f. sp. cubense—were represented in the results of both our literature review and our interrogation of the CABI Distribution Database, in general, our dual approaches revealed distinct sets of plant disease outbreaks and new records, with little overlap. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Obesogenic diet leads to luminal overproduction of the complex IV inhibitor H2S and mitochondrial dysfunction in mouse colonocytes
Authors: Guerbette Thomas , Beaumont Martin , Andriamihaja Mireille , Ciesielski Vincent , Perrin Jean‐Baptiste , Janvier Régis , Randuineau Gwénaëlle , Leroyer Patricia , Loréal Olivier , Rioux Vincent , Boudry Gaëlle , Lan Annaïg 
Published: March 2023

AbstractObesity is characterized by systemic low‐grade inflammation associated with disturbances of intestinal homeostasis and microbiota dysbiosis. Mitochondrial metabolism sustains epithelial homeostasis by providing energy to colonic epithelial cells (CEC) but can be altered by dietary modulations of the luminal environment. Our study aimed at evaluating whether the consumption of an obesogenic diet alters the mitochondrial function of CEC in mice. Mice were fed for 22 weeks with a 58% kcal fat diet (diet‐induced obesity [DIO] group) or a 10% kcal fat diet (control diet, CTRL). Colonic crypts were isolated to assess mitochondrial function while colonic content was collected to characterize microbiota and metabolites. DIO mice developed obesity, intestinal hyperpermeability, and increased endotoxemia. Analysis of isolated colonic crypt bioenergetics revealed a mitochondrial dysfunction marked by decreased basal and maximal respirations and lower respiration linked to ATP production in DIO mice. Yet, CEC gene expression of mitochondrial respiration chain complexes and mitochondrial dynamics were not altered in DIO mice. In parallel, DIO mice displayed increased colonic bile acid concentrations, associated with higher abundance of Desulfovibrionaceae. Sulfide concentration was markedly increased in the colon content of DIO mice. Hence, chronic treatment of CTRL mouse colon organoids with sodium sulfide provoked mitochondrial dysfunction similar to that observed in vivo in DIO mice while acute exposure of isolated mitochondria from CEC of CTRL mice to sodium sulfide diminished complex IV activity. Our study provides new insights into colon mitochondrial dysfunction in obesity by revealing that increased sulfide production by DIO‐induced dysbiosis impairs complex IV activity in mouse CEC.
Intraoperative Antibiotic Use in Patients With Early-onset Scoliosis: Current Practices and Trends
Authors: Faust Millis , Allahabadi Sachin , Louer Craig , Sponseller Paul , Strum Peter , Boachie-Adjei Oheneba , Oetgen Matthew ,   Pediatric Spine Study Group, Swarup Ishaan 
Published: March 2023

Background:
Best Practice Guidelines (BPGs) regarding antibiotic prophylaxis in early-onset scoliosis (EOS) patients were published in September 2019. Recommendations included using intravenous cefazolin and topical vancomycin for all index procedures, plus gram-negative coverage for neuromuscular patients. Guideline adherence is unknown. This study aimed to characterize antibiotic prophylaxis at the time of index growth-friendly procedures and assess changes in practice patterns over time.

Materials and Methods:
This retrospective review of data collected through a multicenter study group included EOS patients undergoing index growth-friendly procedures between January 2018 and March 2021, excluding revisions, lengthenings, and tetherings. Demographics, clinical measurements, intraoperative antibiotics, and 90-day complications were recorded. Descriptive and univariate statistics were utilized. Antibiotic prophylaxis from April 2018 through September 2019 and October 2019 through March 2021 were compared with evaluate change after BPG publication.

Results:
A total of 562 patients undergoing growth-friendly procedures were included. The most common scoliosis types included neuromuscular (167, 29.7%), syndromic (134, 23.8%), and congenital (97, 17.3%). Most index procedures involved magnetically controlled growing rods (417, 74%) followed by vertical expandable prosthetic titanium rib or traditional growing rods (105, 19%). Most patients received cefazolin alone at index procedure (310, 55.2%) or cefazolin with an aminoglycoside (113, 20.1%). Topical antibiotics were used in 327 patients (58.2%), with most receiving vancomycin powder. There was increased use of cefazolin with an aminoglycoside after BPG publication (16% vs. 25%) (P=0.01). Surgical site infections occurred in 12 patients (2.1%) within 90 days of index procedure, 10 pre-BPGs (3%), and 2 post-BPGs (0.9%), with no significant difference in surgical site infection rate by type of antibiotic administered (P>0.05).

Conclusions:
Historical variability exists regarding antibiotic prophylaxis during index growth-friendly procedures for EOS. There continues to be variability following BPG publication; however, this study found a significant increase in antibiotic prophylaxis against gram-negative bacteria after BPG publication. Overall, greater emphasis is needed to decrease variability in practice, improve compliance with consensus guidelines, and evaluate BPG efficacy.

Level of Evidence:
Level III—retrospective.
Fluid Overload Precedes and Masks Cryptic Kidney Injury in Pediatric Acute Respiratory Distress Syndrome
Authors: Dixon Celeste G. , Thadani Sameer , Fitzgerald Julie C. , Akcan-Arikan Ayse , Yehya Nadir 
Published: March 2023

OBJECTIVES:
Given the complex interrelatedness of fluid overload (FO), creatinine, acute kidney injury (AKI), and clinical outcomes, the association of AKI with poor outcomes in critically ill children may be underestimated due to definitions used. We aimed to disentangle these temporal relationships in a large cohort of children with acute respiratory distress syndrome (ARDS).

DESIGN:
Retrospective cohort study.

SETTING:
Quaternary care PICU.

PATIENTS:
Seven hundred twenty intubated children with ARDS between 2011 and 2019.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Daily fluid balance, urine output (UOP), and creatinine for days 1–7 of ARDS were retrospectively abstracted. A subset of patients had angiopoietin 2 (ANGPT2) quantified on days 1, 3, and 7. Patients were classified as AKI by Kidney Disease Improving Global Outcomes (KDIGO) stage 2/3 then grouped by timing of AKI onset (early if days 1–3 of ARDS, late if days 4–7 of ARDS, persistent if both) for comparison of PICU mortality and ventilator-free days (VFDs). A final category of “Cryptic AKI” was used to identify subjects who met KDIGO stage 2/3 criteria only when creatinine was adjusted for FO. Outcomes were compared between those who had Cryptic AKI identified by FO-adjusted creatinine versus those who had no AKI. Conventionally defined AKI occurred in 26% of patients (early 10%, late 3%, persistent 13%). AKI was associated with higher mortality and fewer VFDs, with no differences according to timing of onset. The Cryptic AKI group (6% of those labeled no AKI) had higher mortality and fewer VFDs than patients who did not meet AKI with FO-adjusted creatinine. FO, FO-adjusted creatinine, and ANGPT2 increased 1 day prior to meeting AKI criteria in the late AKI group.

CONCLUSIONS:
AKI was associated with higher mortality and fewer VFDs in pediatric ARDS, irrespective of timing. FO-adjusted creatinine captures a group of patients with Cryptic AKI with outcomes approaching those who meet AKI by traditional criteria. Increases in FO, FO-adjusted creatinine, and ANGPT2 occur prior to meeting conventional AKI criteria.
Vesicular Lymphomatoid Papulosis With DUSP22-IRF4 Rearrangement on Chromosome 6p25.3: A Case Report
Authors: Pan Po-Yang , Liao Jia-Bin , Hsieh Shu-Min , Tseng Hui-Wen 
Published: March 2023

Abstract:
Lymphomatoid papulosis (LyP) with DUSP22-IRF4 rearrangement on chromosome 6p25.3 is a newly identified subtype of LyP. It is characterized by an older age of onset, localized skin lesions, with good prognosis, and it resembles a hybrid of LyP types B and C in histopathology. A limited number of cases have been reported so far. In this article, we reported a case of a 72-year-old man with recurrent episodes of widespread multiple discrete papular or vesicular eruptions on a region of the head, trunk, and 4 extremities for about 3 years. Histopathological examination of a vesicle revealed a subepidermal blister with abundant atypical lymphocytes in the vesicular space, band-like infiltrates in the papillary dermis, along with epidermotropism and pilosebaceous structure involvement. Fluorescence in situ hybridization analysis further demonstrated DUSP22-IRF4 rearrangement on chromosome 6p25.3. A diagnosis of vesicular LyP with this rare subtype was made according to the clinical and pathological findings.
Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases
Authors: Mansour Boulos , Vanecek Tomas , Kastnerova Liubov , Nosek Daniel , Kazakov Dmitry V. , Donati Michele 
Published: March 2023

Abstract:Spitz tumors are melanocytic neoplasms characterized by specific, mutually exclusive driver molecular events, namely genomic rearrangements involving the threonine kinaseBRAFand the tyrosine kinase receptorsALK,NTRK1,NTRK2,NTRK3,MET,RET,ROS1, andMAP3K8or less commonly, mutations inHRASorMAP2K1. We hereby report 5 Spitz tumors with aSQSTM1::NTRK2fusion. All patients were woman with the ages at diagnosis ranging from 30 to 50 years. Locations included the lower extremity (n = 3), forearm, and back (one each). All the neoplasms were superficial melanocytic proliferation with a flat to dome-shaped silhouette, in which junctional spindled and polygonal dendritic melanocytes were mainly arranged as horizontal nests associated with conspicuous lentiginous involvement of the follicular epithelium. Only one case showed heavily pigmented, vertically oriented melanocytic nests resembling Reed nevus. A superficial intradermal component observed in 2 cases appeared as small nests with a back-to-back configuration. In all lesions, next-generation sequencing analysis identified aSQSTM1::NTRK2fusion. A single case studied with fluorescence in situ hybridization for copy number changes in melanoma-related genes proved negative. No further molecular alterations were detected, includingTERT-photspot mutations.
Topical Lidocaine or Lidocaine/Diltiazem Ointment Following Rubber Band Ligation of Hemorrhoids: A Prospective Three-Armed Randomized Controlled Trial
Authors: Kwok Allan M.F. , Smith Stephen R. , Zhao Jie , Carroll Rosemary , Leigh Lucy , Draganic Brian 
Published: March 2023

BACKGROUND:
Rubber band ligation of hemorrhoids causes less pain than excisional hemorrhoidectomy, but many patients still experience significant post-procedure discomfort.

OBJECTIVE:
This study aims to determine if topical lidocaine, with or without diltiazem, is more effective than placebo for analgesia following hemorrhoid banding.

DESIGN:
This is a prospective, randomized, double-blinded, placebo controlled trial. Patients were randomized to 2% lidocaine, 2% lidocaine with 2% diltiazem, or placebo ointment.

SETTINGS:
This study was performed at two university public teaching hospitals and 2 private hospitals in Australia.

PATIENTS:
Consecutive patients aged ≥18 years undergoing hemorrhoid banding were selected.

INTERVENTIONS:
Topical ointments were applied post-procedure 3 times daily for 5 days.

MAIN OUTCOME MEASURES:
Visual analogue pain score, opiate analgesia usage, and patient satisfaction were the main outcome measures.

RESULTS:
Of 159 eligible patients, 99 were randomized (33 in each group). Pain scores were reduced at 1 hour for the lidocaine (OR 4.15 [1.12-15.41] p = 0.03) and lidocaine/diltiazem groups (OR 3.85 (1.05-14.11), p = 0.04) compared with placebo. Patients in the lidocaine/diltiazem group had improved satisfaction (OR 3.82 [1.28-11.44], p = 0.02) and were more likely to recommend the procedure to others (OR 9.33 [1.07-81.72] p = 0.04). Patients in the lidocaine/diltiazem group required approximately 45% less total and in-hospital analgesia compared with placebo. There was no difference in complications between any of the groups.

LIMITATIONS:
A cost/benefit analysis was not performed. Analgesic efficacy appeared to be short-term and the procedures were performed only in the hospital/non-ambulatory setting.

CONCLUSION:
Topical lidocaine improves short-term analgesia, while combination lidocaine/diltiazem is associated with both improved analgesia and patient satisfaction following hemorrhoid banding.