bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C06-9: THE PREDICTIVE VALUE OF RED CELL DISTRIBUTION WIDTH IN VENOUS THROMBOEMBOLISM AND RELATED MORTALITY
Authors: Addai Muhamad Fajri , Maulana Rido , Widyantoro Bambang 
Published: January 2023

Background:
Red cell distribution width (RDW) is a measure of red blood cell size variation and heterogeneity. Recent meta-analyses demonstrated this measurement could be strong predictor in coronary artery disease, chronic heart failure, and atrial fibrillation. Nevertheless, there is no meta-analysis evaluating the role of RDW in prediction of the occurrence of venous thromboembolism (VTE), the third most common cardiovascular disease, and related mortality.

Objective:
To investigate the association of RDW and VTE including deep vein thrombosis (DVT) and pulmonary embolism (PE) and related mortality.

Methods:
Major medical databases were systematically searched for observational studies which assessed the association of RDW and VTE published until May 2022. The databases were searched with predefined protocol without language restriction based on PRISMA guidelines. The analysis was performed in RevMan 5.3 to provide pooled measures for Risk Ratio (RR) and weighted mean difference (WMD).

Results:
Twenty-three studies were enrolled including 6,737 cases and 58,831 controls. Higher RDW was indicated as independent predictors for VTE compared to lower RDW (RR = 1.82, p < 0.00001), comprising DVT and PE (RR = 1.6, p < 0.00001, and RR = 2.05, p = 0.002, respectively). There was also an association between higher RDW and risk of mortality after PE episode with RR = 1.4 (p = 0.0004), involving short- (30-day) and long-term (> 1 year) mortality (RR = 1.79, p = 0.04, and RR = 1.15,p = 0.03, respectively). Compared to lower RDW, higher RDW also revealed a significant association with unprovoked VTE (RR = 2.18, p = 0.02). VTE-group had a higher mean of RDW compared to control with WMD = 1.13% (p < 0.00001), consisting of PE-group (WMD = 0.99%, p < 0.00001) and DVT-group (WMD = 1.07%, p < 0.00001). Among PE patients, The PE-related mortality group also had a higher mean of RDW in comparison to the survivor group with WMD = 1.97%, (p < 0.00001).

Conclusions:
Higher RDW value was associated with the occurrence of VTE, including DVT, PE, unprovoked VTE, and PE-related mortality. Therefore, the use of the potential role of RDW should be emphasized since it is low-cost and simple to obtain, even in a low-resource setting.
PS-C06-11: IRISIN ASSOCIATION WITH NON DIPPER HYPERTENSION DEVELOPMENT IN OBESE PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Shelest Borys , Kovalova Yuliia , Martovytskyi Dmytro , Brek Valeria 
Published: January 2023

Objective:
Recent investigations showed that irisin, as a possible inflammatory marker, can be closely related to heart function, vessels tone regulation and possible development of arterial hypertension HTN.
The purpose of the work was to study the relationship between irisin and the development of non dipper hypertension in obese patients with coronary artery disease CAD.

Design and method:
97 obese hypertensive patients with CAD were enrolled into the study. CAD was presented as chronic coronary syndrome CCS according to 2019 ESC Guidelines, essential HTN as systolic blood pressure SBP ≧ 140 mmHg and or diastolic blood pressure DBP ≧ 90mmgHg. Obesity was assessed as body mass index BMI ≧ 30 kg per m2 according to WHO criteria. The mean age of participants was 53.61 ± 4.88 years. Patients were divided into 2 groups. The first one was with dipper HTN, n 46, and the second one with non dipper HTN, n 51. Dippers were established by Holter monitoring. Serum irisin levels were measured by ELISA.

Results:
It was found that irisin levels were significantly lower in non dipper hypertensive subjects compared with dippers 125.72 ± 15.09 vs 141.53 ± 21.84 ng per mL, p < 0.001. Irisin has a negative correlation with SPR r = 0.29, p < 0.01, and after adjusted for age, sex and BMI it remained a significant link between irisin and SBP, r = 0.21, p = 0.044. In multivariate logistic regression analysis of the irisin odds ratio OR 0.859, 95 per cent Confidence Interval 0.471 to 0.993, p < 0.001 was found to be independent predictors for non dipper hypertension in obese patients with CCS.

Conclusions:
This study shows that decreased irisin levels are significantly associated with the development of non dipper hypertension in obese patients with coronary artery disease.
PS-C06-12: HETEROGENEITY AND OVERLAP OF THE LONGITUDINAL ASSOCIATIONS AMONG INCREASED ARTERIAL STIFFNESS, HYPERTENSION AND DIABETES MELLITUS: A 16-YEAR PROSPECTIVE OBSERVATIONAL STUDY
Authors: Nakano Hiroki , Shiina Kazuki , Takahashi Takamichi , Fujii Masatsune , Iwasaki Yoichi , Matsumoto Chisa , Chikamori Taishiro , Yamashina Akira , Tomiyama Hirofumi 
Published: January 2023

Background:
Hypertension and diabetes mellitus frequently coexist; however, differences in the bi-directional longitudinal relationships of arterial stiffness with hypertension and diabetes mellitus have not yet been clarified.

Methods:
In this 16-year prospective observational study, 3981 middle-aged Japanese subjects without hypertension/diabetes mellitus at the study baseline underwent annual measurements of the blood pressure, serum glycosylated hemoglobin A1c (HbA1c), and brachial-ankle pulse wave velocity (baPWV).

Results:
By the end of the study period, 664, 779, 154 and 406 subjects developed hypertension, prehypertension, diabetes mellitus and prediabetes, respectively. Increased baPWV at the baseline was associated with a significant odds ratio for new onset of prehypertension/hypertension without (beta = 5.0 x 10–3, P < 0.01) or with (beta = 4.0 x 10–3, P < 0.01) coexisting prediabetes/diabetes mellitus; no such association was found with new onset of prediabetes/diabetes mellitus alone. Furthermore, baPWV showed significant longitudinal associations with the development of all of the above conditions. Conversely, elevated mean blood pressure, even in the pre-hypertensive range, showed a significant longitudinal association with increase of the baPWV.

Conclusions:
In middle-aged Japanese subjects, a vicious cycle may be triggered between elevated blood pressure, even from the prehypertensive stage, and arterial stiffening and development of diabetes mellitus may be observed as a cross phenomenon of this vicious cycle with a collateral event. Arterial stiffness may be a key element in the development of hypertension, so that its contribution to cardiovascular risk may be greater in patients with hypertension than in those with diabetes mellitus.
PS-C07-5: ASSOCIATION OF OVERNIGHT URINARY INDICATORS AND BMI WITH NIGHT TIME AND DAYTIME BLOOD PRESSURE IN ELDERLY
Authors: Yamasue Kotaro , Tochikubo Osamu , Ishikawa Yoshihiro 
Published: January 2023

Reportedly, the mean nighttime blood pressure (BP) is the sensitive predictor of cardiovascular diseases and the associated mortality. In this study, we investigated the effect of overnight urinary indicators (levels of sodium, potassium, and sodium to potassium ratio) on daytime and nighttime BP. A total of 108 volunteers (56 males, 52 females) aged between 51 and 76 years (mean age: 65.7 ± 4.9 years) who were not taking any antihypertensive medication participated in the study. Their 24-hour (24-h) BP was measured every 30 minutes with an ambulatory BP monitoring, four times (spring, summer, autumn, and winter) in a year. Overnight urine samples (after the last urination before sleeping and until the first urination on waking up the next day) were easily collected at home using a proportional urine-sampling device, Urine mate P. The ion electrode method was used to measure the sodium and potassium levels excreted in urine. The average values of daytime and nighttime BP were calculated.
Multiple regression and simple linear regression analyses were used to evaluate the association of daytime and nighttime BP with the above-mentioned overnight urinary indicators, age, sex, and BMI.
There were a total of 353 participants over the four seasons. The average values of daytime SBP and DBP were 130.4 ± 20.2 and 83.4 ± 12.7 mmHg, respectively; nighttime SBP and DBP were 113.7 ± 15.8 and 69.8 ± 9.4 mmHg, respectively. Multiple regression analysis of the six factors revealed that none of the variables were linearly combined. For nighttime SBP, the adjusted standard regression coefficients was 0.219 (p < 0.01) for the urinary Na/K ratio, 0.142 (p < 0.05) for age, and 0.119 (p < 0.05) for BMI. However, for daytime SBP it was 0.124 (p < .0.05) for age, -0.232(p < 0.01) for sex, and 0.175 (p < 0.01) for BMI.
Simple linear regular regression analysis showed that nighttime SBP was significantly related to the Na/K ratio, Na, age, and BMI; daytime SBP to sex, BMI, and age.
This demonstrates that overnight urinary Na/K ratio has greater effect on nighttime SBP than BMI and age; therefore, its optimal level should be achieved to control nighttime SBP in the elderly.
PS-C07-8: CENTRAL BLOOD PRESSURE ESTIMATION USING THE RADIAL ARTERIAL PRESSURE WAVEFORM IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS
Authors: Murakami Tomoaki , Shiraishi Masahiro , Takeda Atsuhito 
Published: January 2023

Objective:
Evaluation of central blood pressure is useful in prevention and treatment of cardiovascular diseases. In this study, we examined the accuracy of non-invasively measured central blood pressure in children, adolescents, and young adults.

Design and Method:
This study enrolled 23 patients who had undergone a cardiac catheterization below 30 years old (10.4 ± 7.2 years, 16 males and 7 females). Ascending aortic blood pressure waveforms were invasively recorded using a pressure sensor-mounted catheter (model SPC-454D, Millar Instrument, Inc., Houston, Texas). Simultaneously, radial artery pulse waveforms were non-invasively recorded by tonometry (HEM-9000AI, Omron Healthcare Co., Ltd., Kyoto, Japan). The measurements were performed before and after angiogram (injection of contrast media) except for one case. We analyzed the degree of coincidence between ascending aortic systolic blood pressure (aSBP) and estimated central systolic blood pressure calculated by the instrument (estCBP) in 45 simultaneous recording of aSBP and estCBP. The HEM-9000AI calculates estCBP using rSBP2, which indicates reflected pressure on radial artery.

Results:
The aSBP was 96.2 ± 13.4 mmHg and estCBP was 92.9 ± 14.7mmHg. There was no significant correlation between the aSBPs before and after angiogram in the same case. There was a significant relationship between aSBP and estCBP (r = 0.83, p < 0.0001). The mean difference of the estSBP minus aSBP was -3.3 ± 8.3 mmHg by Bland-Altman analysis. The relationship between aSBP and rSBP1, which indicates forward pressure on radial artery, was stronger than the relationship between aSBP and rSBP2 (r = 0.88, p < 0.0001 vs. r = 0.83, p < 0.0001). The relationship between aSBP and the average of rSBP1 and rSBP2 (r = 0.90, p < 0.0001) was stronger than the relationship between aSBP and estCBP.

Conclusions:
The estSBP calculated using rSBP2 method by HEM 9000AI was significantly correlated to aSBP in children, adolescents, and young adults. However, the correlation coefficient between aSBP and rSBP2 was smaller than that between aSBP and rSBP1. The estCBP calculated by rSBP1 and rSBP2 was strongly correlated to aSBP rather than estCBP by rSBP2 alone.
PS-C07-11: COMPARISON BETWEEN CUFF-BASED AND INVASIVE SYSTOLIC BLOOD PRESSURE AMPLIFICATION
Authors: Bui Tan , Picone Dean , Schultz Martin , Armstrong Matthew , Peng Xiaoqing , Black Andrew , Dwyer Nathan , Thomson Philip Roberts , Adams Heath , Hughes Alun , Sharman James 
Published: January 2023

Objective:
Accurate measurement of central blood pressure (BP) using upper arm cuff-based methods is associated with several factors, including determining the level of systolic BP (SBP) amplification. This study aimed to determine the agreement between cuff-based and invasively measured SBP amplification.

Methods:
Patients undergoing coronary angiography had invasive SBP amplification (brachial SBP minus central SBP) measured simultaneously with cuff-based SBP amplification using a commercially available central BP device (device 1: Sphygmocor Xcel; n = 171, 70% men, 60 ± 10 years) and a now superseded model of a central BP device (device 2: Uscom BP+; n = 52, 83% men, 62 ± 10 years).

Results:
Mean difference (±2SD, limits of agreement) between cuff-based and invasive SBP amplification was 4 mmHg (−12, + 20 mmHg, p < 0.001) for device 1 and -2 mmHg (−14, + 10 mmHg, p = 0.10) for device 2. Both devices systematically overestimated SBP amplification at lower levels and underestimated at higher levels of invasive SBP amplification, but with stronger bias for device 1 (r = −0.68 vs. r = −0.52; Z = 2.72; p = 0.008). Concordance of cuff-based and invasive SBP amplification across quartiles of invasive SBP amplification was low, particularly in the lowest and highest quartiles. The root mean square errors from regression between cuff-based central SBP and brachial SBP were significantly lower (indicating less variability) than from invasive regression models (p < 0.001).

Conclusions:
Irrespective of the difference from invasive measurements, cuff-based estimates of SBP amplification showed evidence of proportional systematic bias and had less individual variability. These observations could provide insights on how to improve the performance of cuff-based central BP.
PS-C08-1: ACCURACY OF CUFF BLOOD PRESSURE AND SYSTOLIC BLOOD PRESSURE AMPLIFICATION
Authors: Bui Tan , Picone Dean , Schultz Martin , Peng Xiaoqing , Black Andrew , Dwyer Nathan , Thomson Philip Roberts , Adams Heath , Chen Chen Huan , Cheng Hao Min , Pucci Giacomo , Wang Jiguang , Goupil Remi , Sharman James 
Published: January 2023

Objective:
Automated cuff measured blood pressure (BP) is the global standard used for diagnosing hypertension, but there are concerns regarding the accuracy of the method. Individual variability in systolic BP (SBP) amplification from central (aorta) to peripheral (brachial) arteries could be related to the accuracy of cuff BP, but this has never been determined and was the aim of this study.

Methods:
Cuff BP and invasive brachial BP were recorded in 755 participants (73% male, aged 64 ± 11 years) receiving coronary angiography at six independent research sites (using seven different automated cuff BP devices). SBP amplification was recorded invasively by catheter and defined as brachial SBP minus aortic SBP.

Results:
Compared with invasive brachial SBP, cuff SBP was significantly underestimated (130 ± 18 mmHg vs. 138 ± 22 mmHg, p < 0.001). The level of SBP amplification varied significantly among individuals (mean ± SD, 7.3 ± 9.1 mmHg; interquartile range, -2.4 to 12.3 mmHg) and was similar to level of difference between cuff and invasive brachial SBP (mean difference -7.6 ± 11.9 mmHg). SBP amplification explained most of the variance in accuracy of cuff SBP (R2 = 19%). The accuracy of cuff SBP was greatest among those participants in the lowest SBP amplification quintiles (ptrend< 0.001). After cuff BP values were corrected for SBP amplification, there was a significant improvement in the mean difference from the intra-arterial standard (p < 0.0001) and in the accuracy of hypertension classification according to 2017 ACC/AHA guideline thresholds (p = 0.005).

Conclusions:
The accuracy of automated cuff BP is markedly influenced by individual variability in SBP amplification. This knowledge can help improve the accuracy of cuff BP.
PS-C08-12: SHORT-TERM BLOOD PRESSURE VARIABILITY AND TARGET-ORGAN EFFECTS IN YOUTH: THE SHIP-AHOY STUDY
Authors: Flynn Joseph , Ferguson Michael , Lande Marc , Meyers Kevin , Samuels Joshua , Urbina Elaine 
Published: January 2023

Background:
Increased blood pressure variability (BPV) has been associated with development of hypertensive target organ damage in adults, including left ventricular (LV) hypertrophy and increased vascular stiffness. Whether similar relationships can be seen in youth is unknown.

Methods:
We assessed short-term BPV and its relation to LV mass and carotid-femoral pulse wave velocity (cfPWV) in 374 participants (mean age 15.5 years, 60% male) in the SHIP-AHOY cohort. Short-term BPV was assessed by examining the differences in systolic and diastolic blood pressure (S/DBP) between 2 SHIP-AHOY study visits. Average time between visits was 25 days. BP was measured by auscultation; 4 BP measurements were conducted at each visit and averaged. BPV was calculated as the difference between the mean BP measurements at the 2 visits. LV mass was measured by m-mode echocardiography and cfPWV was assessed using plethysmography.

Results:
Mean SBP was 123.1 ± 13.0 mmHg on day 1, and 122.3 ± 12.8 mmHg on day 2, with a mean difference of 0.9 ± 7.5 mmHg between the visits. Mean DBP was 71.6 ± 11.6 mmHg on day 1, and 72.0 ± 11.7 mmHg on day 2, with a mean difference of 0.5 ± 10.4 mmHg between the visits. Participants were then divided into 2 groups according to whether their BPV was above (n = 198) or below (n = 176) the median BPV of the entire cohort. LV mass was similar between the groups: 32.7 ± 7.3 gram/ht^2.7 for those above the median vs. 32.8 ± 6.7 for those below the median (P = NS), but cfPWF was significantly higher in those with BPV above the median: 5.2 ± 0.9 meters/second vs. 5.0 ± 0.8 m/s for those below the median, P = 0.03.

Conclusions:
These data suggest that increased short-term BPV may be associated with the development of increased vascular stiffness in youth.
PS-C09-7: PREVALENCE OF CHRONIC KIDNEY DISEASE IN ARTERIAL HYPERTENSION
Authors: Duysenbaeva Aziza Ikhtiyarovna , Mirakbarova Kamola Abdusattarova , Srojidiniva Nigora Zaynutdinovna 
Published: January 2023

Purpose:
To study the prevalence of chronic kidney disease (CKD) markers in patients with arterial hypertension (AH).

Materials and Methods:
A retrospective analysis of 188 case histories of patients with AH of 1–3 degrees (ESC/ESH, 2018) who received inpatient treatmentwas carried out. Mean age 62.8 ± 10.2 years. All patients underwent determination of creatinine, GFR by EPI, uric acid, blood lipids. CKD stages were established according to the modern KDIGO 2013 classification.

Results:
Among the examined patients there were 18% patients with CKDC1, GFR> 90 (n = 34); 56.3% patients with CKDC2, GFR 60–89 (n = 106); 17.5% patients with CKDC3A, GFR 45–59 (n = 33); 5.3% patients with CKDC3B, GFR 30–44 (n = 10); 2.6% patients with CKDC4, GFR 15–29 (n = 5) (p < 0.00001). 98.4% of the examined patients suffered from coronary artery disease; 46.1% had diabetes mellitus. It should be noted that patients with stage 4 CKD were significantly older (55 ± 8 vs 62 ± 9 vs 68 ± 8 vs 69 ± 9 vs 74 ± 16; p < 0.00001). According to the level of SBP, DBP, heart rate, the patients did not differ significantly. SBP was: 134.5 ± 29.3 vs 134.1 ± 31.5 vs 132.5 ± 20.8 vs 138.2 ± 19.4 vs 156 ± 39.1 (p < 0.26). DBP was 87 ± 11.5 vs 84.3 ± 10 vs 82 ± 10 vs 86.3 ± 9.2 vs 90 ± 17.39 (p < 0.25). Patients with stage 4 CKD had severe abdominal obesity. WC: 102.4 ± 10 vs 104.7 ± 13.6 vs 103.2 ± 10.7 vs 101.5 ± 12.4 vs 110 ± 27.3 (p < 0.68). Mean creatinine in the groups was 70.6 ± 14.7 vs 85.2 ± 14.4 vs 102.3 ± 14.6 vs 121.6 ± 25.3 vs 209.6 ± 45.5 (p < 0.00001). Mean eGFR 98.2 ± 7.3 vs 72.9 ± 7.4 vs 53.7 ± 4.2 vs 37.5 ± 4.1 vs 22.6 ± 3.8 p (p < 0.00001). The analysis showed that as the stage of CKD increases, the level of microalbuminuria increases. Thus, MAU indicators were 31.05 ± 25.5 vs 41.6 ± 50.2 vs 38.6 ± 46 vs 96.6 ± 144.7 vs 308.8 ± 147.5 (p < 0.00001). It should be noted, that the high stages of CKD are characterized by significantly more pronounced asymptomatic hyperuremia. At the same time, the level of uric acid in group I was 5.4 ± 1.4 vs 6.5 ± 4.7 vs 6.5 ± 1.7 vs 7.5 ± 1.7 vs 7.8 ± 1.01 (p < 0.00001).

Conclusion:
Among patients with hypertension, the prevalence of CKD is significantly high (82%), which additionally increases the cardiovascular risk of this category of patients.
PS-C09-10: ARTERIAL HYPERTENSION IN RURAL AND NON-RURAL POPULATIONS OF NORTHERN ARGENTINA
Authors: Romano Jose Rene 
Published: January 2023

The prevalence of AHT (arterial hypertension) in patients in this population is not known due to the difficult access of health personnel, and the accessibility and cultural characteristics of these patients.
Some characteristics of these populations, blood pressure and differences with patients in cities, were evaluated. The objective of this study is to evaluate what modifications can be made to improve the health of these hypertensive patients.
The study was carried out in 4 towns in the province of Formosa that are 512, 354, 162 and 103 km away from the capital city. It was carried out in all cases in public institutions and the patients used as controls were patients not referred from rural areas. During the year 2020. A survey and pressure measurement were carried out with validated sphygmomanometers and under the recommended conditions. The data was analyzed by the STatistix program.
Of 1034 patients attended, a random sample of 20% of said population was taken and a similar sample in the city, it was observed in the rural sample average age of 48 years, 52% of male sex, the BP (blood pressure) S (systolic)1/2 145 and diastolic D 83, and with AHT 51.1% S and 39.3% D. 24% of the patients attended consulted for AHT, they presented AHT 180/110: 10% were referred 3% of the patients for presenting signs of target organ damage. Those from the city: age ½ 39 years old, consulted due to hypertension 42%, mean BP S 141 D 85, the percentage of hypertensive patients in the consultation was 43% S and 35% D. They were treated in rural areas 8, 75% of native aboriginal race that was increasing over time with the number of attentions (1 pte to 5 to 6 ptes).
It was demonstrated in these populations, the differences with patients who consult in the city of age to which they consult, the degree of control of hypertensive patients and the number of patients known to be hypertensive and consult a control for it, it was possible to serve populations special, in this case aboriginal and measure variables in them. It is hoped in the future to evaluate the usefulness at the population level of these services.