bluuebunny/crossref_metadata_2025_split huggingface dataset:
General Factors That Reduce Cardiovascular Risk in People With Schizophrenia
Authors: Al-kayed Jarrah , Okoli Chizimuzo C. 
Published: September 2023

Background
The life expectancy of individuals with schizophrenia in the United States is 20% shorter than that of the general population owing to cardiovascular disease (CVD). It is crucial to identify the factors that reduce CVD risk in these individuals.

Objective
In this systematic review, we examined the factors associated with CVD in people with schizophrenia.

Methods
We searched 3 electronic databases for English articles published before April 2023. Investigators assessed the factors associated with 2 cardiovascular health outcomes among people with schizophrenia: the 10-year coronary heart disease (CHD)/CVD risk and peak oxygen uptake (VO2Peak/max).

Results
We retrieved 17 studies from the search. Investigators examined factors affecting 10-year CHD/CVD risk in 11 studies and VO2Peak/max in 6 studies among people with schizophrenia. We found that individuals who had low metabolic symptoms (ie, hypertension and hyperglycemia), did not smoke, engaged in continuous CVD risk assessments, had a shorter duration of the diagnosis and hospitalization, and were of normal weight had a lower 10-year CHD/CVD risk. Furthermore, individuals who engaged in specific physical activity had a higher VO2Peak/max. Finally, those taking antipsychotic medications had a higher 10-year CHD/CVD risk and a lower VO2Peak/max.

Conclusions
The CVD risk factors observed in the general population are common among people with schizophrenia. When these risk factors are controlled, the 10-year CHD/CVD risk and VO2Peak/max of these individuals may be improved. Given the elevated CVD risk associated with antipsychotic medications, future researchers should examine modifying CVD risk factors to mitigate the additional risks associated with medication use in this population.
Comparative efficacy and safety of 4 atypical antipsychotics augmentation treatment for major depressive disorder in adults: A systematic review and network meta-analysis
Authors: Wang Jia , Li Wenwei , Li Mengting , Wu Hanbiao , Qiu Zhikun 
Published: September 2023

Background:
Atypical antipsychotic (AAP) augmentation is an alternative strategy for patients with major depressive disorder (MDD) who had an inadequate response to antidepressant therapy (ADT). We aimed to compare and rank the efficacy and safety of 4 AAPs in the adjuvant treatment of MDD.

Methods:
We searched randomized controlled trials (RCTs) published and unpublished from the date of databases and clinical trial websites inception to April 30, 2023. The evidence risk of bias (RoB) and certainty are assessed using the Cochrane bias risk tool and grading of recommendations assessment, development, and evaluation (GRADE) framework, respectively. Using network meta-analysis, we estimated summary risk ratios (RRs) or standardized mean difference (SMD) based on the random effects model.

Results:
56 eligible studies comprising 11448 participants were included. In terms of primary efficacy outcome, compared with placebo (PBO), all AAPs had significant efficacy (SMD = −0.40; 95% CI, −0.68 to −0.12 for quetiapine (QTP); −0.35, −0.59 to −0.11 for olanzapine (OLA); −0.28, −0.47 to −0.09 for aripiprazole (ARI) and −0.25, −0.42 to −0.07 for brexpiprazole (BRE), respectively). In terms of acceptability, no significant difference was found, either agents versus agents or agents versus PBO. In terms of tolerability, compared with the PBO, QTP (RR = 0.24; 95% CI,0.11–0.53), OLA (0.30,0.10–0.55), ARI (0.39,0.22–0.69), and BRE (0.37,0.18–0.75) were significantly less well tolerated. 8 (14.2%) of 56 trials were assessed as low RoB, 38 (67.9%) trials had moderate RoB, and 10 (17.9%) had high RoB; By the GRADE, the certainty of most evidence was low or very low.

Conclusion:
Adjuvant AAPs had significant efficacy compared with PBO, but treatment decisions must be made to balance the risks and benefits.
Global research trends in artificial intelligence for critical care with a focus on chord network charts: Bibliometric analysis
Authors: Cheng Teng-Yun , Yu-Chieh Ho Sam , Chien Tsair-Wei , Chou Willy 
Published: September 2023

Background:
The field of critical care-related artificial intelligence (AI) research is rapidly gaining interest. However, there is still a lack of comprehensive bibliometric studies that measure and analyze scientific publications on a global scale. Network charts have traditionally been used to highlight author collaborations and coword phenomena (ACCP). It is necessary to determine whether chord network charts (CNCs) can provide a better understanding of ACCP, thus requiring clarification. This study aimed to achieve 2 objectives: evaluate global research trends in AI in intensive care medicine on publication outputs, coauthorships between nations, citations, and co-occurrences of keywords; and demonstrate the use of CNCs for ACCP in bibliometric analysis.

Methods:
The web of science database was searched for a total of 1992 documents published between 2013 and 2022. The document type was limited to articles and article reviews, and titles and abstracts were screened for eligibility. The characteristics of the publications, including preferred journals, leading research countries, international collaborations, top institutions, and major keywords, were analyzed using the category-journal rank-authorship-L-index score and trend analysis. The 100 most highly cited articles are also listed in detail.

Results:
Between 2018 and 2022, there was a sharp increase in publications, which accounted for 92.8% (1849/1992) of all papers included in the study. The United States and China were responsible for nearly 50% (936/1992) of the total publications. The leading countries, institutes, departments, authors, and journals in terms of publications were the US, Massachusetts Gen Hosp (US), Medical School, Zhongheng Zhang (China), and Science Reports. The top 3 primary keywords denoting research hotspots for AI in critically ill patients were mortality, model, and intensive care unit, with mortality having the highest burst strength (4.49). The keywords risk and system showed the highest growth trend (0.98) in counts over the past 4 years.

Conclusions:
This study provides valuable insights into the potential for ACCP and future research opportunities. For AI-based clinical research to become widely accepted in critical care practice, collaborative research efforts are necessary to strengthen the maturity and robustness of AI-driven models using CNCs for display.
Effect of opioid-free anesthesia on the incidence of postoperative nausea and vomiting: A meta-analysis of randomized controlled studies
Authors: Zhang Yanan , Ma Dandan , Lang Bao , Zang Chuanbo , Sun Zenggang , Ren Shengjie , Chen Huayong 
Published: September 2023

Background:
Research on opioid-free anesthesia has increased in recent years; however, it has never been determined whether it is more beneficial than opioid anesthesia. This meta-analysis was primarily used to assess the effect of opioid-free anesthesia compared with opioid anesthesia on the incidence of postoperative nausea and vomiting.

Methods:
We searched the electronic databases of PubMed, the Cochrane Library, Web of Science and Embase from 2014 to 2022 to identify relevant articles and extract relevant data. The incidence of postoperative nausea and vomiting, time to extubation, pain score at 24 hours postoperatively, and time to first postoperative rescue analgesia were compared between patients receiving opioid-free anesthesia and those receiving standard opioid anesthesia. Differences in the incidence of postoperative nausea and vomiting were evaluated using risk ratios (95% confidence interval [CI]). The significance of the differences was assessed using mean differences and 95% CI. The heterogeneity of the subject trials was evaluated using the I
2 test. Statistical analysis was performed using the RevMan 5.4 software.

Results:
Fourteen randomized controlled trials, including 1354 participants, were evaluated in the meta-analysis. As seen in the forest plot, the OFA group had a lower risk of postoperative nausea and vomiting than the control group (risk ratios = 0.41, 95% CI: 0.33–0.51, P < .00001; n = 1354), and the meta-analysis also found that the OFA group had lower postoperative analgesia scores at 24 hours (P < .000001), but time to extubation (P = .14) and first postoperative resuscitation analgesia time (P < .54) were not significantly different.

Conclusions:
Opioid-free anesthesia reduces the incidence of postoperative nausea and vomiting while providing adequate analgesia without interfering with postoperative awakening.
Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis
Authors: Li Qian , Li Wen , Chen Menglu , Chai Yihui , Guan Liancheng , Chen Yunzhi 
Published: September 2023

Background:
To investigate the association between sepsis and the vitamin D receptor (VDR) gene polymorphisms.

Methods:
Databases including PubMed, Cochrane Library, EMbase, CNKI, Wanfang Data, and VIP Data were systematically searched. The association was assessed using odds ratios (ORs), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.4.

Results:
We identified a total of 5 studies. The relationship between VDR gene polymorphisms (Apa I, Bsm I, Taq I, and Fok I), and incidence of sepsis was investigated. The results of this meta-analysis showed that the allelic contrast model (F vs f, P = .03, OR = 0.65, 95% CI = 0.44–0.95), dominant genetic model (FF vs Ff + ff, P = .02, OR = 0.53, 95% CI = 0.30–0.91), and codominance genetic model (FF vs ff, P = .03, OR = 0.39, 95% CI = 0.16–0.91) of VDR Fok I locus increased the risk of sepsis, and the lack of association between the VDR Fok I gene polymorphism and the risk assessment of sepsis, based on the ethnic subgroup analysis, might be attributable to the small sample size. The risk of sepsis with Apa I, Bsm I, and Taq I did not appear to be correlated.

Conclusion subsections:
This meta-analysis revealed that the VDR Fok I polymorphism is closely associated with the susceptibility to sepsis, and patients with sepsis have lower 25-hydroxyvitamin D levels. VDR Fok I gene mutations may change the risk of sepsis.
Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers
Authors: Zhong Guping , Luo Xiaojin , Li Ji , Liao Yuanhang , Gui Guan , Sheng Jianwen 
Published: September 2023

Objective:
Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results.

Methods:
We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC.

Results:
Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04–1.55, P
heterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04–2.01, P
heterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81–0.98, P
heterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72–0.93, P
heterogeneity = 0.15, P = .01) among Asian.

Conclusion:
Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.
Recurrent flash pulmonary edema in unilateral renal artery stenosis with contralateral kidney shrinkage: A case report
Authors: Cheon Ji Eun , Kim Hyo Jin 
Published: September 2023

Rationale:
Flash pulmonary edema is a critical medical condition characterized by sudden and severe fluid accumulation in the lungs, which poses an immediate and life-threatening emergency. This can arise from a variety of underlying causes. This manuscript presents a case of recurrent pulmonary edema that was successfully managed through the insertion of a renal artery stent.

Patient concerns:
A 78-year-old woman visited the emergency room with recurrent acute dyspnea. Computed tomography renal angiography revealed renal artery stenosis of a single-functioning kidney.

Diagnoses:
Flash pulmonary edema caused by renal artery stenosis of a functioning single kidney.

Interventions:
Percutaneous transluminal angioplasty and stenting were performed for the renal artery stenosis.

Outcomes:
The patient’s kidney function rapidly improved, and she has been free of flash pulmonary edema for 2 years.

Lessons:
Flash pulmonary edema can have various causes and can immediately be a life-threatening emergency. However, it can be treated with percutaneous revascularization if it is caused by renal artery stenosis. This case report reinforces the importance of accurate and immediate diagnosis when dealing with flash pulmonary edema. This case emphasizes the potential therapeutic benefit of renal artery stenting in the management of flash pulmonary edema caused by renal artery stenosis in patients with a single-functioning kidney.
Prevention of delayed gastric emptying after right colectomy with extended lymphadenectomy: A randomized controlled trial
Authors: Popescu Răzvan Cătălin , Leopa Nicoleta , Iordache Ionut-Eduard , Dan Cristina , Moldovan Cosmin , Ghioldis Andrei-Cristian , Olteanu Cornelia Minodora , Kacani Andrea , Cindea Iulia , Popescu Ioana 
Published: September 2023

Background:
Delayed gastric emptying sometimes occurs after right colectomy with extended lymphadenectomy. The aim of this randomized controlled trial is to evaluate the effect on delayed gastric emptying after performing a fixation of the stomach to the retrogastric tissue to return the stomach to a physiological position after right colectomy with lymphadenectomy, including gastrocolic lymph nodes dissection for proximal transverse colon cancer.

Methods:
From January 2015 to December 2020, patients undergoing right colectomy with extensive lymphadenectomy for proximal transverse colon cancer were randomly assigned to either the gastropexy group or the conventional group. In the gastropexy group, the posterior wall of the stomach, at the level of the antrum, was sutured to the retrogastric tissue to prevent the abnormal shape that the gastric antrum acquires together with the duodeno-pancreatic complex, the shape that leads to an obstruction of the antrum region and to the delay in emptying the gastric contents.

Results:
Mean age, sex, comorbidities, and right colectomy procedures were similar in the 2 groups. Delayed gastric emptying developed in twelve patients in the conventional group (38.7%) versus 4 patients (12.1%) in the gastropexy group (P = .014). The total number of complications was higher in the conventional group (14 complications) than in the gastropexy group (7 complications). According to univariate analysis, gastropexy significantly lowered the risk of delayed gastric emptying (P = .014). Overall morbidity was 9.7% in the conventional group versus none in the gastropexy group. Postoperative hospitalization was longer in the conventional group (7.61 ± 3.26 days) than in the gastropexy group (6.24 ± 1.3 days; P = .006).

Conclusion:
Gastropexy decreases the occurrence of delayed gastric emptying after right colectomy with extended lymphadenectomy for proximal transverse colon cancer.
Efficacy and safety of daratumumab in the treatment of relapsed/refractory multiple myeloma: A meta-analysis of randomized controlled trials
Authors: Huang Zeng-Yi , Jin Xiao-Qin , Liang Qi-Lian , Zhang Ding-Yue , Han Han , Wang Zhen-Wei 
Published: September 2023

Background:
Daratumumab as a monoclonal antibody has shown promising results in the treatment of relapsed/refractory multiple myeloma (RRMM). However, the efficacy and safety of daratumumab-based regimens compared to control regimens have not been fully established.

Methods:
The search was conducted using electronic databases (PubMed, Web of Science, Embase, and Cochrane Central Register of Controlled Trials databases) up to December 2022. We conducted a meta-analysis of randomized controlled trials that evaluated the efficacy and safety of daratumumab in the treatment of RRMM. Data were extracted from eligible studies and were presented as hazard ratio or risk ratio (RR) with 95% confidence interval (CI).

Results:
A total of 5 randomized controlled trials comprising 2003 patients were included in this meta-analysis. The results showed that daratumumab-based regimens significantly improved progression-free survival compared to control regimens (hazard ratio = 0.44, 95% CI 0.32–0.60, P < .00001). Additionally, daratumumab-based regimens significantly improved overall response rate compared to control regimens (RR = 1.25, 95% CI 1.16–1.36, P < .00001). the rate of minimal residual disease was also significantly higher in the daratumumab-based regimens (RR = 6.10, 95% CI 4.09–9.11, P < .00001). However, there was an increased risk of pneumonia, upper respiratory tract infections, and diarrhea in the daratumumab-based regimens.

Conclusion:
Our results suggest that daratumumab-based regimens are effective in the treatment of RRMM, improving progression-free survival, minimal residual disease, and overall response rate. However, there is an increased risk of pneumonia, upper respiratory tract infections, and diarrhea. Further studies are needed to determine the long-term safety and efficacy of daratumumab in the treatment of multiple myeloma.
Prognostic impact of serum testosterone in metastatic hormone-naive prostate cancer: a systematic review and meta-analysis
Authors: Puche-Sanz Ignacio , Chiu Peter , Morillo Ana C. , Gomez-Gomez Enrique 
Published: September 2023

Purpose of review
In daily practice, there is an unmet medical need for biomarkers that facilitate therapeutic decision-making in the metastatic hormone sensitive prostate cancer (mHSPC) scenario. Although recent studies have highlighted the potential of testosterone as a prognostic and predictive marker in prostate cancer, the evidence is controversial. The objective of this review was to summarize and analyze the scientific evidence regarding the prognostic role of basal testosterone levels in patients with mHSPC.

Methods
A systematic review was performed. Three authors selected the articles from Web of Science, PubMed, Scopus, and Cochrane Library electronic databases. Risk of bias was assessed by the Newcastle Ottawa Scale.

Recent findings
Most of the selected articles suggest that low testosterone levels before starting hormonal blockade imply a worse prognosis for patients with mHSPC. However, the quality of the evidence is poor, the studies are heterogeneous, and it is not possible to meta-analyze most of the published results.

Summary
Testosterone is an accessible and affordable biomarker. If it were correctly demonstrated that it harbors a prognostic and/or predictive role in the mHSPC setting, it could represent an advance in decision-making in these patients. Well designed prospective studies are needed to correctly answer this question.
The relationship between microbial contaminations of embryo transfer catheters with pregnancy outcome after embryo transfer
Authors: Rezaie Masomeh , Rezaie Mohammad Jafar , Seyedoshohadaie Fariba , Alahvaisi Azra , Azizian Khalil , Nouri Bijan , Babaneghad Gajoti Samira 
Published: September 2023

Background:
Different stages of assisted reproductive technologies are susceptible to contamination by various microorganisms.

Objective:
The aim of the study was to investigate the relationship between microbial contamination of embryo transfer catheters and the pregnancy outcome after embryo transfer.

Methods:
This cohort study was conducted on 60 patients candied for in vitro fertilization and embryo transfer cycles from 2021 to 2022. All embryos were transferred using a sterile syringe. The catheter contamination was checked by the microbial culture method, and in the case of microbial culture that were negative, polymerase chain reaction was done to confirm the result. The data analyzed using STATA 17 to determine the impact of catheter contamination on the clinical pregnancy rate.

Results:
The average age of peoples whose microbial culture was positive was lower than that of people whose microbial culture was negative (P<0.05). Also the results showed that people who live in villages have more positive microbial cultures than people who live in cities (P<0.05). Also there is no difference between the number of successful implantations and the pregnancy outcome between people whose microbial culture results were positive or negative.

Conclusion:
The results of the current study showed that the contamination of the embryo transfer catheter with microorganisms under our investigation did not affect the pregnancy outcome.
Caregivers' Perspectives on Ethical Challenges and Patient Safety in Tele-Palliative Care
Authors: Schuessler Nadine , Glarcher Manela 
Published: September 2023

Tele-palliative care enables people with a life-limiting illness to consult with palliative care staff without having to leave their homes but requires commitment from all stakeholders, particularly on ethical challenges and patient safety issues. When using telecommunications and virtual technology, ethical challenges and patient safety aspects must be taken into account.
The aim was to describe formal and informal caregivers' opportunities in tele-palliative care and the associated ethical and safety challenges using a Whittemore and Knafl integrative review method. Ethical and patient safety perspectives were extracted from studies reporting on tele-palliative care interventions. Content on ethically considerable information on the intervention was coded, categorized, and summarized into a matrix developed in advance from literature on socio-technical arrangements and eHealth applications.
Nine studies from experimental and nonexperimental research were included. Four studies reported exclusively on the perspective of formal caregivers, 3 studies addressed the perspective of patients and informal caregivers, and 2 studies covered the perspectives of both. Studies of tele-palliative care interventions implicate effects on patient-caregiver relationships but also show that technology is not seen as a replacement of holistic palliative care. However, the authors do not address other relevant ethical issues (eg, sustainability) or consider aspects of patient safety.
There is a need for further research to assess privacy, data security, and patient safety in tele-palliative care from the perspective of caregivers as telehealth becomes increasingly important.