bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-genome and transcriptome analyses provide insights into genomic variation and differential gene expression profiles related to disease resistance and fatty acid biosynthesis in eastern black walnut (Juglans nigra)
Authors: Zhou Huijuan , Yan Feng , Hao Fan , Ye Hang , Yue Ming , Woeste Keith , Zhao Peng , Zhang Shuoxin 
Published: February 2023

AbstractWalnut (Juglans) species are used as nut crops worldwide. Eastern black walnut (EBW, Juglans nigra), a diploid, horticultural important woody species is native to much of eastern North America. Although it is highly valued for its wood and nut, there are few resources for understanding EBW genetics. Here, we present a high-quality genome assembly of J. nigra based on Illumina, Pacbio, and Hi-C technologies. The genome size was 540.8 Mb, with a scaffold N50 size of 35.1 Mb, and 99.0% of the assembly was anchored to 16 chromosomes. Using this genome as a reference, the resequencing of 74 accessions revealed the effective population size of J. nigra declined during the glacial maximum. A single whole-genome duplication event was identified in the J. nigra genome. Large syntenic blocks among J. nigra, Juglans regia, and Juglans microcarpa predominated, but inversions of more than 600 kb were identified. By comparing the EBW genome with those of J. regia and J. microcarpa, we detected InDel sizes of 34.9 Mb in J. regia and 18.3 Mb in J. microcarpa, respectively. Transcriptomic analysis of differentially expressed genes identified five presumed NBS-LRR (NUCLEOTIDE BINDING SITE-LEUCINE-RICH REPEAT) genes were upregulated during the development of walnut husks and shells compared to developing embryos. We also identified candidate genes with essential roles in seed oil synthesis, including FAD (FATTY ACID DESATURASE) and OLE (OLEOSIN). Our work advances the understanding of fatty acid bioaccumulation and disease resistance in nut crops, and also provides an essential resource for conducting genomics-enabled breeding in walnut.
“Both Your Sexes”: A Non-Binary Approach to Gender History, Trans Studies and the Making of the Self in Modern Britain
Authors: Moulton Mo 
Published: February 2023

Abstract
Using the life-writing of historian and playwright Muriel St. Clare Byrne (1895-1983), this article develops the concept of a non-binary historical methodology. It argues that historians should take gender as a historically contingent category to allow alternative logics of embodiment, selfhood, desire, and relationality to be more clearly seen. Drawing on trans studies, the article situates Byrne within contemporary conversations about universal bi-sexuality within sexology and psychoanalysis. Her rewriting of the psychosexual model in her memoir, which underwrote a claim to ‘both her sexes’, represents one of the paths foreclosed by the mid-century turn to the gender/sex/sexuality model.
Scattering in a partially open waveguide: the forward problem
Authors: Bourgeois Laurent , Fliss Sonia , Fritsch Jean-François , Hazard Christophe , Recoquillay Arnaud 
Published: February 2023

AbstractThis paper is devoted to an acoustic scattering problem in a 2D partially open waveguide, in the sense that the left part of the waveguide is closed, that is with a ‘bounded’ cross-section, while the right part is bounded in the transverse direction by some perfectly matched layers that mimic the situation of an open waveguide, that is with an ‘unbounded’ cross-section. We prove well-posedness of such scattering problem in the Fredholm sense (uniqueness implies existence) and exhibit the asymptotic behaviour of the solution in the longitudinal direction with the help of the Kondratiev approach. Having in mind the numerical computation of the solution, we also propose some transparent boundary conditions in such longitudinal direction, based on Dirichlet-to-Neumann operators. After proving such artificial conditions actually enable us to approximate the exact solution, some numerical experiments illustrate the quality of such approximation.
On the use of asymptotically motivated gauge functions to obtain convergent series solutions to nonlinear ODEs
Authors: Naghshineh Nastaran , Reinberger W Cade , Barlow Nathaniel S , Samaha Mohamed A , Weinstein Steven J 
Published: February 2023

AbstractWe examine the power series solutions of two classical nonlinear ordinary differential equations of fluid mechanics that are mathematically related by their large-distance asymptotic behaviours in semi-infinite domains. The first problem is that of the ‘Sakiadis’ boundary layer over a moving flat wall, for which no exact analytic solution has been put forward. The second problem is that of a static air–liquid meniscus with surface tension that intersects a flat wall at a given contact angle and limits to a flat pool away from the wall. For the latter problem, the exact analytic solution—given as distance from the wall as a function of meniscus height—has long been known (Batchelor, G. K. (1967) An Introduction to Fluid Dynamics, chapter 1: The physical properties of fluids. Cambridge). Here, we provide an explicit solution as meniscus height versus distance from the wall to elucidate structural similarities to the Sakiadis boundary layer. Although power series solutions are readily obtainable to the governing nonlinear ordinary differential equations, we show that—in both problems—the series diverge due to non-physical complex or negative real-valued singularities. In both cases, these singularities can be moved by expanding in exponential gauge functions motivated by their respective large distance asymptotic behaviours to enable series convergence over their full semi-infinite domains. For the Sakiadis problem, this not only provides a convergent Taylor series (and conjectured exact) solution to the ODE, but also a means to evaluate the wall shear parameter (and other properties) to within any desired precision. Although the nature of nonlinear ODEs precludes general conclusions, our results indicate that asymptotic behaviours can be useful when proposing variable transformations to overcome power series divergence.
Nurses’ perceptions of the potential evolution of their role in antibiotic stewardship in nursing homes: a French qualitative study
Authors: Bridey Céline , Le Dref Gaëlle , Bocquier Aurélie , Bonnay Stéphanie , Pulcini Céline , Thilly Nathalie 
Published: February 2023

AbstractBackgroundIn nursing homes, infections and antibiotic prescriptions are frequent. Nursing home nurses (NHNs) and advanced practice registered nurses (APRNs) could promote antibiotic stewardship (ABS). Few studies have explored nurses’ knowledge, perceptions and practices towards ABS in nursing homes and none has investigated the potential evolution of their roles.ObjectivesTo explore French nurses’ perceptions on ABS, current and future potential roles in ABS in nursing homes, as well as facilitators and barriers.MethodsWe conducted a qualitative study in north-eastern France between October 2020 and March 2021 using semi-structured individual interviews with NHNs and a focus group with APRNs. Transcripts of the interviews were analysed using a thematic analysis.ResultsTwenty NHNs and seven APRNs participated. They were aware of antibiotic misuse and potential adverse events but lacked knowledge on some ABS aspects. NHNs’ current ABS roles ranged from the detection of clinical infectious signs to clinical monitoring of residents, with some heterogeneity between nurses. They had positive opinions towards playing a more prominent role in ABS. In the future, with additional training, changes in the legislative framework and greater multidisciplinary teamwork, NHNs thought they could prescribe laboratory microbiological analyses and some targeted antibiotic treatments. APRNs thought they could prescribe first-line antibiotics for urinary tract infections.ConclusionsFrench NHNs’ current ABS roles could be expanded and new roles might be considered while taking into account several facilitators and barriers. According to APRNs, they could help to compensate for the limited presence of doctors in nursing homes and develop infectious diseases skills.
Understanding comorbidities and health disparities related to COVID-19: a comprehensive study of 776 936 cases and 1 362 545 controls in the state of Indiana, USA
Authors: Zidan Nader , Dey Vishal , Allen Katie , Price John , Zappone Sarah Renee , Hebert Courtney , Schleyer Titus , Ning Xia 
Published: February 2023

Abstract

Objective
To characterize COVID-19 patients in Indiana, United States, and to evaluate their demographics and comorbidities as risk factors to COVID-19 severity.

Materials and Methods
EHR data of 776 936 COVID-19 cases and 1 362 545 controls were collected from the COVID-19 Research Data Commons (CoRDaCo) in Indiana. Data regarding county population and per capita income were obtained from the US Census Bureau. Statistical analysis was conducted to determine the association of demographic and clinical variables with COVID-19 severity. Predictive analysis was conducted to evaluate the predictive power of CoRDaCo EHR data in determining COVID-19 severity.

Results
Chronic obstructive pulmonary disease, cardiovascular disease, and type 2 diabetes were found in 3.49%, 2.59%, and 4.76% of the COVID-19 patients, respectively. Such COVID-19 patients have significantly higher ICU admission rates of 10.23%, 14.33%, and 11.11%, respectively, compared to the entire COVID-19 patient population (1.94%). Furthermore, patients with these comorbidities have significantly higher mortality rates compared to the entire COVID-19 patient population. Health disparity analysis suggests potential health disparities among counties in Indiana. Predictive analysis achieved F1-scores of 0.8011 and 0.7072 for classifying COVID-19 cases versus controls and ICU versus non-ICU cases, respectively.

Discussion
Black population in Indiana was more adversely affected by COVID-19 than the White population. This is consistent to findings from existing studies. Our findings also indicate other health disparities in terms of demographic and economic factors.

Conclusion
This study characterizes the relationship between comorbidities and COVID-19 outcomes with respect to ICU admission across a large COVID-19 patient population in Indiana.
Mesh-free least-squares reverse-time migration
Authors: Deng Xiaofan , Wu Han , Sun Chengyu , Gao Rui 
Published: February 2023

AbstractThe reflectivity of the subsurface can be precisely determined using least-squares reverse-time migration (LSRTM). As LSRTM necessitates solving the wave equation, the numerical solution method of the wavefield directly determines the quality of the migration image. The conventional LSRTM method usually uses the finite difference method based on a regular grid to calculate the wavefield. Due to the stepwise approximation of an irregular surface with a regular grid, scattering noise may occur in the propagation of the wavefield, which affects the quality of the image. In addition, the conventional LSRTM cannot effectively handle the models with rugged topography. The finite difference method generated by radial basis functions (FD-RBF) is a mesh-free method and can construct interpolation functions to solve the wave equations numerically according to arbitrarily distributed spatial coordinate points. Therefore, we use the FD-RBF method to develop a mesh-free LSRTM approach to eliminate the influence of the inherent limitation of a regular grid on the imaging. Numerical examples show that the mesh-free LSRTM method can better represent the curved or steep interface within the model and is also suitable for models with rugged topography. The LSRTM method can provide higher-quality images and effectively reduce the memory required for calculations.
Immunities of Foreign Officials for International Crimes: The Dilemmas of Strategic Litigation
Authors: Mégret Frédéric 
Published: February 2023

Abstract
This article analyses the elusive search to restrict immunities for foreign officials accused of international crimes as a form of strategic litigation. It emphasizes how litigation ‘constitutes’ legal reality beyond particular victories. Problematizing ‘success’ in litigation makes it possible to pay attention to unintended effects and even perverse outcomes of certain strategic routes. A proper understanding of success as more than victory is then used to assess three routes that have been used to try and limit, circumvent or oppose functional immunities of former officials. These routes are found not to be of even value for human rights, independently of their legal validity or their odds of success: the idea that international crimes are not committed as part of state functions trivializes the ‘public’ character of most international crimes; the argument that the jus cogens norm that prohibits international crimes trumps immunities either constantly needs to be finessed or sets up too dramatic a showdown; the idea that immunities offend human rights finds some favour as the one that is closest to the heart of human rights, although its tendency to symbolically sanctify the right to prosecutions could also have problematic ripple effects. Offered as a contribution to thinking through the rights implications of litigation, the article insists on the responsibility of human rights lawyers in creating legal worlds of their own making.
Hibiscus Mealybug (Hemiptera: Pseudococcidae) – Biology, Host Plants, Current Management Practices, and a Field Guide for North America
Authors: Olabiyi David , Middleton Eric , Ahmed Muhammad Z , Osborne Lance S , McKenzie Cindy L , Diepenbrock Lauren 
Published: February 2023

Abstract
Hibiscus mealybug, Nipaecoccus viridis (Newstead), is an invasive, highly polyphagous pest that has recently established in Florida. This pest is historically known to heavily effect citrus production in other citrus-producing regions and has similarly negatively impacted citrus groves in several counties. Hibiscus mealybug was first found infesting citrus in one county in 2019 and has rapidly spread across counties and onto additional hosts in only a few years. Here we review the known distribution and biology of hibiscus mealybug, including a description of life stages, known host plants in Florida, and management options. Additionally, a field diagnostics guide is presented to assist in early detection and prevent the spread of N. viridis in other regions. We anticipate that information shared here will help in slowing its spread in the United States.
Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation
Authors: Nicosia Michael , Lee Juyeun , Beavers Ashley , Kish Danielle , Farr George W , McGuirk Paul R , Pelletier Marc F , Lathia Justin D , Fairchild Robert L , Valujskikh Anna 
Published: February 2023

Abstract
Aquaporins are a family of ubiquitously expressed transmembrane water channels implicated in a broad range of physiological functions. We have previously reported that aquaporin 4 (AQP4) is expressed on T cells and that treatment with a small molecule AQP4 inhibitor significantly delays T cell mediated heart allograft rejection. Using either genetic deletion or small molecule inhibitor, we show that AQP4 supports T cell receptor mediated activation of both mouse and human T cells. Intact AQP4 is required for optimal T cell receptor (TCR)-related signaling events, including nuclear translocation of transcription factors and phosphorylation of proximal TCR signaling molecules. AQP4 deficiency or inhibition impairs actin cytoskeleton rearrangements following TCR crosslinking, causing inferior TCR polarization and a loss of TCR signaling. Our findings reveal a novel function of AQP4 in T lymphocytes and identify AQP4 as a potential therapeutic target for preventing TCR-mediated T cell activation.
Superficial acral fibromyxoma: a case of missed diagnosis
Authors: Debordes Pierre-Antoine , Hamoudi Ceyran , Weingertner Noelle , Di Marco Antonio 
Published: February 2023

Abstract
Superficial acral fibromyxoma (SAFM) is a rare, benign, slow-growing fibroblastic tumour of the soft tissue that is part of the group of myxoid soft-tissue neoplasms. It is a rare entity and usually occurs in the acral regions. We report the case of a 64-year-old man who presented to the emergency room for a lesion expected to have occurred as a result of an ingrown toenail. Because this patient had a history of repeated recurrences despite multiple surgical wedge excisions, we performed a complete surgical excision, and the pathological analysis confirmed the suspected diagnosis of SAFM. There was no recurrence at the 6-month follow-up. This case highlights the fact that this tumour is still misunderstood and underrecognized by surgeons and this often leads to delayed diagnosis. Although it is a rare entity, clinicians should be aware of this tumour in cases of recurring ingrown toenails.
Fragility fracture of talar neck in an osteoporotic patient treated by posterior-to-anterior screw fixation under hindfoot endoscopy: a case report
Authors: Morio Futoshi , Morimoto Shota , Tachibana Toshiya , Iseki Tomoya 
Published: February 2023

Abstract
Fragility fractures of the talar neck are extremely rare. Here, we describe a case of fragility fracture of the talar neck associated with osteoporosis in a 76-year-old female, who was treated by posterior-to-anterior screw fixation under hindfoot endoscopy. A 76-year-old female cleaner with a history of osteoporosis complained of pain in her right ankle when going downstairs. Radiological findings revealed a fragility fracture of the talar neck associated with osteoporosis. Because the patient was elderly and it was difficult to treat using a prolonged non-weight-bearing cast, we performed a posterior-to-anterior parallel dual screw fixation under hindfoot endoscopy for this case. As a result, the patient was able to return to work 8 weeks after surgery without pain, dysfunction or complication. Osteosynthesis with posterior-to-anterior screw fixation under hindfoot endoscopy successfully treated a rare case of fragility fracture of the talar neck in a 76-year-old female cleaner.
Same-sex families’ rights and the European Union: incompatible or promising relationship?
Authors: Křičková Lenka 
Published: February 2023

Abstract
This article deals with the role of the European Union (EU) in enhancing rights of same-sex couples and their children (‘rainbow families’). It describes EU actions in this area and examines what influence they can have within the Member States, using the Czech Republic as a case study. The article argues that, despite the EU’s general lack of competence in family law matters, the relationship between the EU and rainbow families’ rights, in theory, no longer appears incompatible, but rather promising, as the EU bodies have found ways to address these issues. In practical terms. However, the question raised in this article’s title cannot be definitively answered without data from the Member States. Here, the findings from the Czech Republic demonstrate that the EU law’s potential has not been fulfilled in practice yet. Therefore, it would be too soon to celebrate the EU as a significant player in the rainbow families’ rights arena. As the Czech example suggests, if the EU wants to truly enhance rainbow families’ rights, it will probably need to be more explicit about that because the Member States, particularly their national courts, may not find or pave the way to utilize EU law themselves.
A Principle-based Account of Self-attacking Arguments in Gradual Semantics
Authors: Beuselinck Vivien , Delobelle Jérôme , Vesic Srdjan 
Published: February 2023

AbstractThe issue of how a semantics should deal with self-attacking arguments was always a subject of debate among argumentation scholars. A consensus exists for extension-based semantics because those arguments are always rejected (as soon as the semantics in question respects conflict-freeness). In case of gradual semantics, the question is more complex, since other criteria are taken into account. In this paper, we check the impact of those arguments by using a principle-based approach. Principles like self-contradiction and strong self-contradiction prescribe how to deal with self-attacking arguments. We show that they are incompatible with the well-known equivalence principle (which is satisfied by almost all the existing gradual semantics), as well as with some other principles (e.g. counting). This incompatibility was not studied until now and the class of semantics satisfying self-contradiction is under-explored. In the present paper, we explore that class of semantics. We show links and incompatibilities between several principles. We define a new general oriented argumentation semantics that satisfies (strong) self-contradiction and a maximal number of compatible principles. We introduce an iterative algorithm to calculate our semantics and prove that it always converges. We also provide a characterization of our semantics. Finally, we experimentally show that our semantics is computationally efficient.
Application of radiomics to meningiomas: A systematic review
Authors: Patel Ruchit V , Yao Shun , Huang Raymond Y , Bi Wenya Linda 
Published: February 2023

Abstract

Background
Quantitative imaging analysis through radiomics is a powerful technology to non-invasively assess molecular correlates and guide clinical decision-making. There has been growing interest in image-based phenotyping for meningiomas given the complexities in management.

Methods
We systematically reviewed meningioma radiomics analyses published in PubMed, Embase, and Web of Science until December 20, 2021. We compiled performance data and assessed publication quality using the radiomics quality score (RQS).

Results
A total of 170 publications were grouped into 5 categories of radiomics applications to meningiomas: Tumor detection and segmentation (21%), classification across neurologic diseases (54%), grading (14%), feature correlation (3%), and prognostication (8%). A majority focused on technical model development (73%) versus clinical applications (27%), with increasing adoption of deep learning. Studies utilized either private institutional (50%) or public (49%) datasets, with only 68% using a validation dataset. For detection and segmentation, radiomic models had a mean accuracy of 93.1 ± 8.1% and a dice coefficient of 88.8 ± 7.9%. Meningioma classification had a mean accuracy of 95.2 ± 4.0%. Tumor grading had a mean area-under-the-curve (AUC) of 0.85 ± 0.08. Correlation with meningioma biological features had a mean AUC of 0.89 ± 0.07. Prognostication of the clinical course had a mean AUC of 0.83 ± 0.08. While clinical studies had a higher mean RQS compared to technical studies, quality was low overall with a mean RQS of 6.7 ± 5.9 (possible range −8 to 36).

Conclusions
There has been global growth in meningioma radiomics, driven by data accessibility and novel computational methodology. Translatability toward complex tasks such as prognostication requires studies that improve quality, develop comprehensive patient datasets, and engage in prospective trials.