bluuebunny/crossref_metadata_2025_split huggingface dataset:
Condiciones socioeconómicas más bajas se asocian con tasas de sepsis infantil más altas pero con resultados similares
Authors: Gonzalez Gustavo , Arias-Lopez Maria Del Pilar , Bordogna Adriana , Palacio Gladys , Siaba Serrate Alejandro , Fernández Ariel Leonardo , Jabornisky Roberto , Kissoon Niranjan 
Published: April 2023

La sepsis es una causa importante de morbilidad y mortalidad pediátrica, especialmente en países de bajos recursos. Los datos sobre la prevalencia regional, las tendencias de mortalidad y su relación con variables socioeconómicas son escasos. Objetivo: determinar la prevalencia regional, mortalidad y situación sociodemográfica en pacientes con diagnóstico de sepsis severa (SS) y shock séptico (ShS) ingresados a Unidades de Cuidado Intensivo Pediátrico (UCIPs). Pacientes y Método:Se incluyeron pacientes de 1 a 216 meses de edad ingresados en 47 UCIPs participantes con diagnóstico de SS o ShS entre el 1 de enero de 2010 y el 31 de diciembre de 2018. Se efectuó análisis secundario de la base de datos del Programa de Benchmarking de Calidad de la Sociedad Argentina de Terapia Intensiva (SATI-Q) para SS y ShS, y revisión de los informes anuales del Ministerio de Salud de Argentina y del Instituto Nacional de Estadística y Censos para los índices sociodemográficos de los años correspon- dientes. Resultados: Se registraron 45.480 ingresos en 47 UCIPs, 3.777 con diagnóstico de SS y ShS. La prevalencia combinada de SS y ShS disminuyó del 9,9% en 2010 al 6,6% en 2018. La mortalidad combinada disminuyó del 34,5% al 23,5%. El análisis multivariado mostró que el Odds ratio (OR) de la asociación entre la mortalidad del SS y el ShS fue de 1,88 (IC 95%: 1,46-2,32) y 2,4 (IC 95%: 2,16- 2,66) respectivamente, ajustada por enfermedad maligna, PIM2 y ventilación mecánica. La prevalen- cia de SS y ShS en diferentes regiones sanitarias (RS) se asoció con el porcentaje de pobreza y la tasa de mortalidad infantil (p < 0,001). Sin embargo, no hubo asociación entre la mortalidad por sepsis y la RS ajustada por PIM2. Conclusiones: La prevalencia y la mortalidad por SS y ShS han disminuido con el tiempo en las UCIP participantes. Las condiciones socioeconómicas más bajas se asociaron con una mayor prevalencia pero con resultados similares de la sepsis.
Relationship Between Results of Genexpert RT-PCR and Erythrocyte Sedimentation Rate in Suspected Tuberculosis Patients
Authors: Listiyowati Tanti , Wardani Dita Pratiwi Kusuma , Sudarsono Tantri Analisawati , Wijayanti Linda 
Published: April 2023

Pulmonary tuberculosis (TB) is an infectious disease that attacks the lungs and is caused by the bacterium Mycobacterium tuberculosis. The GeneXpert RT-PCR examination (Xpert MTB / RIF) is a development of a diagnostic tool that can automatically detect the presence of Mycobacterium tuberculosis (MTB) by molecular examination and can be used to detect MTB resistance to rifampicin. Erythrocyte sedimentation rate (ESR) is a test used to determine the rate at which erythrocytes settle in the blood. The purpose of this study was to determine the relationship between GeneXpert RT-PCR results and ESR in suspected tuberculosis patients. This research uses a cross-sectional study. The sample used in this study were 56 new suspected TB patients who had never been treated for ATD and underwent GeneXpert RT-PCR examination. Sampling was carried out by purposive sampling with the TCM Rif Sen group and negative results. A total of 27 patients (96.4%) with Rif Sen's GeneXpert RT-PCR results had high ESR values. 15 patients (53.6%) with negative GeneXpert RT-PCR results had normal ESR values. The results of the Chi Square test (X2) show that p-value = 0.000 OR = 0.032. There is a significant relationship between GeneXpert and ESR values ​​in suspected tuberculosis
Pengaruh Citra Merek, Kualitas Produk Dan Promosi Terhadap Keputusan Pembelian Produk Pada PT Trimitra Warna Jaya
Authors: Raphael Romeo Lenardo  , Inda Sukati  
Published: April 2023

Tujuan penelitian untuk meneliti tentang pengaruh citra merek, kualitas produk dan promosi terhadap keputusan pembelian produk pada, PT Trimitra Warna Jaya. Dasar metode yang digunakan dalam penelitian ini yaitu metode penelitian kuantitatif. penelitian survey menjadi pilihan dalam penelitian ini serta penggunaan kuesioner dalam proses pengumpulan data hasil survey yang didapat dari indormasi dari responden. Populasi yang digunakan dalam peneliti dalam meneliti yaitu konsumen yang pernah melakukan pembelian cat Asian paints di PT Trimitra warna jaya dalam periode bulan oktober 2022 hingga bulan oktober 2023. Penentuan besar sampel yang dapat dilakukan dengan rumus Cochran. Metode analisis data digunakan melalui uji validitas, uji reliabilitas, uji normalitas, uji multikolinearitas, uji heteroskedastisitas, analisis regresi linier bergada, analisis koefisien determinasi (R2), uji t dan uji f. Hasil penelitian dapat menunjukkan pada citra merek memilik t hitung 1,565 < 1,98498 dan 0,121 > 0,05 bahwa tidak didapati secara parsial pengaruh positif serta signifikan citra merek atas keputusan pembelian konsumen di PT Trimitra Warna Jaya. Kemudian pada kualitas produk memilik t hitung 3,145 > 1,98498 dan 0,002 < 0,05 bahwa didapati secara parsial pengaruh positif serta signifikan kualitas produk atas keputusan pembelian konsumen di PT Trimitra Warna Jaya. Kemudian pada promosi memilik t hitung 6,029 > 1,98498 dan 0,000 < 0,05 bahwa didapati secara parsial pengaruh positif serta signifikan promosi atas keputusan pembelian konsumen di PT Trimitra Warna Jaya. Pada hasil secara simultan didapati 36,740 > 2,70 dan signifikansi 0,000 < 0,05 maka citra merek, kualitas produk serta promosi atas keputusan pembelian konsumen di PT Trimitra Warna jaya
The Effect of Organization Culture, Work Discipline, and Communication on Employee Performance in PT Tjikko Sentral Industrial
Authors: Claudia Michelli Dwi , Pujiarti Pujiarti 
Published: April 2023

In this Reseach author want to know, do analyze, and determine the effect of Organization Culture, Work Discipline, and Communication on Employee Performance in PT Tjikko Sental Industrial. In this research, author uses quantitative description method which the data from questionnaire. the result from analyze in this research, the author use the validity test, reliability test, classic assuption test, statistical model testing,t test and F test. From the results of the research that has been done, it shows that the value of Adjusted R Square shows the value of the coefficient of determination (R2) is 0.215 or 215%, that means the ability to provide information between the independent and dependent variables is small by 21.5%, the remaining by 78.5% is the other factors outside of this reserach. Based on the t test result, it showed variable X1 ( Organizational Culture) has a value 3,380 > 1,993 with a signifikan 0,0001 < 0,05 that means H0 is rejected and Ha is accepted, variable X2 ( Work Dicipline) has a value 3,279 > 1,993 with a signifikan 0,002 < 0,05 that means H0 is rejected and Ha is accepted, variable X3 ( Communication) has a value 3,620 > 1,993 with a signifikan 0,001 < 0,05 that means H0 is Rejeceted and Ha is accepted. Based on the t test result, between independent variabel has the independent variable has a partial impact on the dependent variable. Based on Ftest, the result has a value 7.682 > 2.73 with a signifikan value signifikan 0,000 < 0,05 that means H0 is Rejected and Ha is accepted, that means the independent variable has a simultaneous influence on the dependent variable .
ANALISIS FAKTOR PENYEBAB TIDAK TERCAPAINYA TARGET PENERIMAAN RETRIBUSI DAERAH KABUPATEN KUPANG
Authors: Dawu Leopold , Malaikosa Merlyn Salomi , Sonbay Yolinda Yanti 
Published: April 2023

ABSTRAK
Tujuan yang ingin dicapai dalam penelitian ini adalah untuk: 1) Untuk mengetahui faktor yang menyebabkan tidak tercapainya target penerimaan retribusi daerah Kabupaten Kupang Tahun Anggaran 2015-2019, 2) Untuk mengetahui upaya-upaya apa saja yang dilakukan pemerintah daerah Kabupaten Kupang dalam mengoptimalisasikan penerimaan retribusi daerah Kabupaten Kupang. Jenis dan sumber data menggunakan pendekatan deskriptif kualitatif dan pengumpulan data dilakukan dengan cara wawancara dan dokumentasi di masing-masing Organisasi Perangkatan Daerah (OPD) atau dinas pengelola retribusi daerah yang berada di Kabupaten Kupang.Hasil penelitian menunjukan bahwa terdapat 11 faktor yang menyebabkan tidak tercapainya target penerimaan retribusi daerah Kabupaten Kupang
Kata Kunci : Penerimaan, Retribusi daerah

ABSTRACT
The objectives to be achieved in this study are to: 1) To find out the factors that cause the failure to achieve the Kupang Regency regional levy revenue target for the 2015-2019 Fiscal Year, 2) To find out what efforts are being made by the Kupang Regency regional government in optimizing Kupang regency levy receipts. . Data types and sources use a qualitative descriptive approach and data collection is carried out by means of interviews and documentation in eachRegional Device Organization (OPD) or regional levy management office located in Kupang Regency.The results showed that there were 11 factors that caused the non-achievement of the Kupang regency levy receipt target
Keywords : Revenue, Regional levy
ANALISIS KINERJA KEUANGAN DITINJAU DARI RASIO AKTIVITAS DAN RASIO PROFITABILITAS (STUDI KASUS PADA PT GUDANG GARAM Tbk)
Authors: Luan Oscar Benyamin , Manane Desmon Redikson 
Published: April 2023

Penelitian ini bertujuan untuk menilai kinerja keuangan ditinjau dari rasio aktivitas dan rasio profitabilitas pada PT Gudang Garam Tbk dari tahun 2015-2019. Hasil penelitian ini menyatakan bahwa rasio aktivitas menunjukkan kinerja yang tidak baik karena berada dibawah standar industri yang ditetapkan, berdasarkan alat analisis rasio perputaran persediaan yaitu tahun 2015 sebesar 1,9 kali, tahun 2016 sebesar 2,0 kali, tahun 2017 sebesar 2,2 kali, tahun 2018 sebesar 2,5 kali, dan tahun 2019 sebesar 2,6 kali. Rasio perputaran total aset yaitu tahun 2015 sebesar 1,11 kali, tahun 2016 sebesar 1,21 kali, tahun 2017 sebesar 1,25 kali, tahun 2018 sebesar 1,39 kali, dan tahun 2019 sebesar 1,41 kali. Rasio perputaran modal kerja yaitu tahun 2015 sebesar 3,80 kali, tahun 2016 sebesar 3,76 kali, tahun 2017 sebesar 3,94 kali, tahun 2018 sebesar 4,11 kali, dan tahun 2019 sebesar 4,12 kali. Rasio profitabilitas menunjukkan kinerja yang tidak baik karena berada dibawah standar industri yang ditetapkan, disebabkan berdasarkan alat analisis Return On Aset (ROA) yaitu tahun 2015 sebesar 10,16%, tahun 2016 sebesar 10,61%, tahun 2017 sebesar 11,62%, tahun 2018 sebesar 11,28%, dan tahun 2019 sebesar 13,83%. Berdasarkan alat analisis Return On Equity (ROE) yaitu tahun 2015 sebesar 16,98%, tahun 2016 sebesar 16,87%, tahun 2017 sebesar 18,38%, tahun 2018 sebesar 17,27%, dan tahun 2019 sebesar 21,36%. Kesimpulan dari hasil penelitian ini adalah kinerja keuangan PT Gudang Garam Tbk ditinjau dari rasio aktivitas dan rasio profitabilitas menunjukkan kinerja yang tidak baik karena berada dibawah standar industri yang ditetapkan. Hal ini berarti PT Gudang Garam Tbk tidak efisien dalam mengelolah aset dan mengelolah modal dalam meningkatkan laba, akan tetapi hasil yang diperoleh berada dalam skala 50-60% dari standar industri yang ditetapkan, sehingga kinerja keuangan PT Gudang Garam Tbk berada dalam kondisi cukup efisien, dan jika dilihat dari perkembangan perusahaan secara keseluruhan menunjukkan kinerja yang baik. Hal ini berarti pengukuran standar industri menurut (Kasmir, 2008) hanya menjadi salah satu pengukuran standar industri dalam menilai kinerja suatu perusahaan. Oleh sebab itu penelitian ini menjadi acuan bagi PT Gudang garam Tbk agar meningkatkan kinerjanya sehingga dapat tumbuh dan berkembang secara berkesinambungan.
ANALISIS PENGENDALIAN INTERNAL PERSEDIAAN BARANG DAGANG PADA PT. HYPERMART 369 KUPANG
Authors: Nufninu Penina , Dawu Leopold Melkiano Triangga 
Published: April 2023

PT. Hypermart 369 Kupang dalam proses bisnisnya tidak luput dari masalah sistem pengendalian persediaan. Hal itu dibuktikan sering terjadi kehilangan dan kelebihan barang dagang pada jenis barang tertentu. Hal ini menyebabkan resiko keusangan dan kerusakan barang dagang. Tujuan dari penelitian ini untuk mengetahui Pengendalian Internal Barang Dagang pada PT. Hypermart 369 Kupang menggunakan Teknik analisis deskriptif. Hasil penelitian menunjukkan bahwa penerapan pengedalian interanal barang dagang pada PT. Hypermart 369 Kupang sebesar 75.04% sesuai dengan COSO framework dan tergolong dalam kategori efektif. Dimana komponen informasi dan komunikasi sudah sesuai dengan COSO framework, sedangkan komponen dengan beberapa bagian yang belum sesuai dengan COSO framework adalah lingkugan pengendalian, penilaian resiko, aktivitas pengendalian, dan monitoring. Disarankan agar sistem manajemen resiko seperti menetapkan safety stok/persediaan aman untuk menjamin selalu tersedianya persediaan di gudang, Manajemen PT. Hypermart 369 sistem bongkar muat sampai barang masuk di gudang.
Kata kunci : Pengendalian Internal, COSO framework.
Efectos colaterales del tramadol versus paracetamol durante la labor de parto en gestantes atendidas en el Hospital de Especialidades José Carrasco Arteaga, periodo 2014-2019
Authors: Cobos Tobar Juana Karina , Corella Verdugo Nadia Mireya 
Published: April 2023

Introducción: el parto representa la forma más severa de dolor experimentado en la vida de una mujer, su manejo adecuado se asocia con una experiencia satisfactoria. Objetivo: determinar los efectos colaterales del tramadol versus paracetamol durante la labor de parto en gestantes atendidas en el Hospital de especialidades José Carrasco Arteaga, año 2014-2019. Metodología: se realizó un estudio descriptivo transversal, se recolectó información de 216 historias clínicas electrónicas del sistema AS-400. La información se registró en una ficha de recolección de datos elaborada por la investigadora Juana Cobos, y posteriormente en el programa estadístico SPSS v. 15. Resultados: la edad media de la población materna fue 30 años de edad, (94%), el 66,2% fue multípara, el 94% presentó controles prenatales adecuados, la duración promedio de la labor de parto fue de 8 a 17 horas en primíparas (53,12%) y de 5 a 11 horas en multíparas (50,3%), el tramadol se administró en el 42,59% y produjo efectos colaterales como náusea (57,61%), cefalea (47,83%), vómito (9,78) e insomnio (9,78), la dosis habitual de tramadol fue de 100mg. vía intramuscular (95,65%); el paracetamol produjo efectos adversos con menor frecuencia y se prescribió 1000mg. vía intravenosa en un 65,6%, las complicaciones perinatales como estado fetal no tranquilizador, taquicardia fetal y otras se observaron con mayor frecuencia con tramadol. Conclusión: Finalmente, el tramadol ocasionó más efectos adversos que el paracetamol al administrase durante el trabajo de parto. Área de estudio: ginecología
Postoperative Complications after Surgical Management of Mandibular Angle Fracture
Authors: Akter Sharmin , Ashrafi Zobaida , Manira Sirajum , Rahman Mohammad Asifur , Rashid Md Harun Ur 
Published: April 2023

Introductions: Mandibular angle fractures represent a high percentage and an important clinical challenge because of their treatment pattern and the highest postsurgical complication rate among all mandibular fractures.
Materials and methods: The objectives of this cross-sectional observational study were to observe the postoperative complications after surgical management of a mandibular angle fracture and to facilitate early detection of complications and reduction of patients’ morbidity. This study was carried out among forty patients with mandibular angle fractures who were managed by open reduction and internal fixation by miniplate osteosynthesis. All the study patients were evaluated clinically pre- and postoperatively for various parameters at the 1st week, 2nd week, 1st month, and 4th month. Radiographs (OPG, PA skull, lateral skull, and CT scan of the oral and maxillofacial region) were taken pre- and postoperatively to assess complications. The infection was detected by culture and a sensitivity test. Nerve injury was evaluated by the “tactile test”, the brush directional stroke test by using a ’00’ camel hair brush, and the pinprick test performed by using a sterile 27-gauge syringe needle. Occlusion and chewing were evaluated postoperatively according to the Treatment Scoring System developed by V. Uglesic in 1993. The data was analyzed using the SPSS version 20 statistical software.
Results: In this study, most of the patients (85%) were male and the mean age was 24.5 years. In the fracture line third molar was present in 55% cases. The most common complication of this study shows postoperative nerve injury 30% cases. Infection in 10% cases, malocclusion in 7.5% cases. Slight restricted mouth opening in 5% cases. Other complications such as malunion,, delayed union, and non-union were absent.
Conclusion: The most common complication after surgery is nerve injury along with infection and malocclusion. A careful preoperative assessment, early surgical intervention, meticulous surgical technique, postoperative care and appropriate rehabilitation are the main concern to prevent neurological and other complications.
Update Dent. Coll. j: 2023; 13(1): 9-13
Trapping analysis of ants (Hymenoptera, Formicidae) in Kurunthamalai, Coimbatore, Tamil Nadu, India
Authors: Sornapriya J. , Lekeshmenaswamy M. 
Published: April 2023

Ant species were collected from three different methods bait trapping (BTM), all-out search method (AOSM), and pitfall trapping method (PTM) method. A total of 14 species belonging to the eight genera and four subfamilies are listed in the Palamalai region. Monomorium indicum, Solenopsis germinata, Trichomyrmex crinieceps, Trichonymex glaber, Camponotus mendax, C. guticollis, C. irritans, C. parius, C. rufoglaucus, Oecophylla smaragdina,,Diacamma indicum, Leptogenys chinensis, Tetraponera rufonigra and Tetraponera spp were reported. Shannon Wiener, Simpson diversity, Dominance, Evenness, Menhinick, Margalef, Fisher alpha and Berger- Parker calculations and diversity richness are reported.
Budget impact analysis of enzalutamide for the treatment of hormone-sensitive metastatic prostate cancer in Italy
Authors: Fiorentino Francesca , Di Rienzo Paolo 
Published: April 2023

Backgroud: After demonstrating additional benefit versus standard of care in ARCHES and ENZAMET studies, enzalutamide was reimbursed in Italy in May 2022 by the National Health Service (NHS) for the treatment of hormone-sensitive metastatic prostate cancer (mHSPC).
Objective: This study estimates the financial impact associated to the introduction of enzalutamide for patients with mHSPC.
Methods: A budget impact model was developed with a dynamic cost calculator approach, in which the impact on subsequent lines of therapy was considered. The analysis considered the NHS perspective and a 3-year time horizon. Included costs were related to drug acquisition and administration, monitoring, patient follow-up and adverse events. Eligible population was estimated based on published literature, real-world data and experts’ opinion while market shares were assessed considering real-world data and assumptions. National tariffs and published literature were considered for unit costs.
Results: Eligible population was estimated at 6,200, 6,206 and 6,212 in years 1, 2 and 3 respectively. The introduction of enzalutamide, considering a progressive increase of market shares of 10%, 18% and 25%, is expected to overall increase NHS healthcare expenditure by € 688 thousands and € 2.6 and € 5.6 million in years 1, 2 and 3 respectively, corresponding on average to 1.55% of the overall prostate cancer expenditure.
Results are robust across one-way sensitivity analyses, while confidential discount agreements of on-patent drugs might significantly impact the estimates.
Conclusion: The introduction of enzalutamide for the treatment of adult patients with mHSPC is expected to increase patients’ health with a moderate impact on costs for the Italian NHS.
Models and mechanisms in philosophy of psychiatry: Editorial introduction
Authors: Kästner Lena , Walter Henrik 
Published: April 2023

The background for this special issue is the multidisciplinary workshop "Minds, Models and Mechanisms: Current Trends in Philosophy of
Psychiatry" which was held at Saarland University in April 2021. Though we had to switch to an online format due to the pandemic, the
discussions at the event have been extremely inspiring. It brought together experts from diverse disciplines, like clinical psychiatry,
neuroscience, computational modelling, philosophy of mind and cognition, and philosophy of science. Joining forces, researchers from these
disciplines presented their ideas on the subject. In the aftermath of the workshop, the organizers issued an open call for contributions.
After a rigorous review process five papers made it into the final issue, each making an original contribution to the field.
Anti-Cholera toxin activity of selected polyphenols from Careya arborea, Punica granatum, and Psidium guajava
Authors: Charla Rajitha , Patil Priyanka P. , Patil Vishal S. , Bhandare Vishwambhar V. , Karoshi Veeresh , Balaganur Venkanna , Joshi Rajesh K. , Harish Darasaguppe R. , Roy Subarna 
Published: April 2023

IntroductionCareya arborea, Punica granatum, and Psidium guajava are traditionally used to treat diarrheal diseases in India and were reported to show anti-Cholera toxin activity from our earlier studies. As polyphenols are reported to neutralize Cholera toxin (CT), the present study investigated the inhibitory activity of selected polyphenols from these plants against CTB binding to GM1 receptor using in silico, in vitro, and in vivo approaches.MethodsMolecular modelling approach was used to investigate the intermolecular interactions of selected 20 polyphenolic compounds from three plants with CT using DOCK6. Based on intermolecular interactions, two phenolic acids, Ellagic acid (EA) and Chlorogenic acid (CHL); two flavonoids, Rutin (RTN) and Phloridzin (PHD) were selected along with their respective standards, Gallic acid (GA) and Quercetrin (QRTN). The stability of docked complexes was corroborated using molecular dynamics simulation. Furthermore, in vitro inhibitory activity of six compounds against CT was assessed using GM1 ELISA and cAMP assay. EA and CHL that showed prominent activity against CT in in vitro assays were investigated for their neutralizing activity against CT-induced fluid accumulation and histopathological changes in adult mouse.Results and discussionThe molecular modelling study revealed significant structural stability of the CT-EA, CT-CHL, and CT-PHD complexes compared to their respective controls. All the selected six compounds significantly reduced CT-induced cAMP levels, whereas EA, CHL, and PHD exhibited &gt; 50% binding inhibition of CT to GM1. The EA and CHL that showed prominent neutralization activity against CT from in vitro studies, also significantly decreased CT-induced fluid accumulation and histopathological changes in adult mouse. Our study identified bioactive compounds from these three plants against CT-induced diarrhea.