bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmet need for family planning and associated factors among currently married women in Nepal: A further analysis of Nepal Demographic and Health Survey - 2022
Authors: KC Saugat Pratap , Adhikari Bikram , Pandey Achyut Raj , Pandey Merina , Kakchapati Sampurna , Giri Santosh , Sharma Shreeman , Lamichhane Bipul , Gautam Ghanshyam , Joshi Deepak , Dulal Bishnu Prasad , Regmi Shophika , Baral Sushil Chandra 
Published: August 2023

AbstractIntroductionFamily planning (FP) is crucial for improving maternal and newborn health outcomes, promoting gender equality, and reducing poverty. Unmet FP needs persist globally, especially in South Asia and Sub-Saharan Africa leading to unintended pregnancies, unsafe abortions, and maternal fatalities. Nepal, despite efforts, faces significant unmet FP needs, particularly among specific groups. This study aims to identify the determinants of unmet needs for FP from a nationally representative survey.MethodsWe analyzed the data from nationally representative Nepal Health Demographic Survey 2022. There was a total of 14,845 participants in the survey selected through systematic random sampling technique. Weighted analysis using R statistical software was conducted binary and multinomial logistic regression were performed to assess associations between independent variables and unmet FP needs.ResultsThe total unmet FP need was 20.8% (95%CI: 19.7, 21.9) accounting 13.4% (95%CI: 12.5, 14.4) for unmet need for limiting and 7.4% (95%CI: 6.8, 8.0) for unmet for spacing. In multivariable regression model, age, ethnicity, religion, participants and partners education level, province, occupation, wealth quintile, parity and desire for child were statistically associated with total unmet need of FP. Lower odds of total unmet need for FP were present in 20-34 years and 35-49 years compared to <20 years, women belonging to Madhesi ethnic group(AOR: 0.79, 95% CI:0.65, 0.97) compared to brahmin/Chhetri, women from richest (AOR: 0.73, 95% CI:0.59, 0.90) and middle wealth quintile (AOR: 0.83, 95% CI:0.70, 0.99) group compared poorest wealth quintile and women belonging to rural area (AOR: 0.89, 95%CI: 0.80, 0.99) compared to urban area. Whereas higher odds of total unmet need for FP were present in non-Hindu women (AOR: 1.30, 95% CI:1.10, 1.53) compared to Hindu women and women belonging to Madhesh, Lumbini and Sudurpaschim province compared to Bagmati province.ConclusionNepal faces relatively high unmet FP needs across various socio-demographic strata. Addressing these needs requires targeted interventions focusing on age, ethnicity, religion, education, and socio-economic factors to ensure universal access to FP services.
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Authors: Grandits Thomas , Augustin Christoph M. , Haase Gundolf , Jost Norbert , Mirams Gary R. , Niederer Steven A. , Plank Gernot , Varró András , Virág László , Jung Alexander 
Published: August 2023

AbstractComputer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimental data can become a significant computational burden. To mitigate the computational burden, the present study introduces a neural network (NN) that emulates the AP for given maximum conductances of selected ion channels, pumps, and exchangers. Its applicability in pharmacological studies was tested on synthetic and experimental data. The NN emulator potentially enables massive speed-ups compared to regular simulations and the forward problem (find drugged AP for pharmacological parameters defined as scaling factors of control maximum conductances) on synthetic data could be solved with average root-mean-square errors (RMSE) of 0.47 mV in normal APs and of 14.5 mV in abnormal APs exhibiting early afterdepolarizations (72.5% of the emulated APs were alining with the abnormality, and the substantial majority of the remaining APs demonstrated pronounced proximity). This demonstrates not only very fast and mostly very accurate AP emulations but also the capability of accounting for discontinuities, a major advantage over existing emulation strategies. Furthermore, the inverse problem (find pharmacological parameters for control and drugged APs through optimization) on synthetic data could be solved with high accuracy shown by a maximum RMSE of 0.21 in the estimated pharmacological parameters. However, notable mismatches were observed between pharmacological parameters estimated from experimental data and distributions obtained from the Comprehensive in vitro Proarrhythmia Assay initiative. This reveals larger inaccuracies which can be attributed particularly to the fact that small tissue preparations were studied while the emulator was trained on single cardiomyocyte data. Overall, our study highlights the potential of NN emulators as powerful tool for an increased efficiency in future quantitative systems pharmacology studies.
Overlapping Neural Correlates Underpin Theory of Mind and Semantic Cognition: Evidence from a Meta-Analysis of 344 Functional Neuroimaging Studies
Authors: Balgova Eva , Diveica Veronica , Jackson Rebecca L. , Binney Richard J. 
Published: August 2023

AbstractKey unanswered questions for cognitive neuroscience include whether social cognition is underpinned by specialised brain regions and to what extent it simultaneously depends on more domain-general systems. Until we glean a better understanding of the full set of contributions made by various systems, theories of social cognition will remain fundamentally limited. In the present study, we evaluate a recent proposal that semantic cognition plays a crucial role in supporting social cognition. While previous brain-based investigations have focused on dissociating these two systems, our primary aim was to assess the degree to which the neural correlates are overlapping, particularly within two key regions, the anterior temporal lobe (ATL) and the temporoparietal junction (TPJ). We focus on activation associated with theory of mind (ToM) and adopt a meta-analytic activation likelihood approach to synthesise a large set of functional neuroimaging studies and compare their results with studies of semantic cognition. As a key consideration, we sought to account for methodological differences across the two sets of studies, including the fact that ToM studies tend to use nonverbal stimuli while the semantics literature is dominated by language-based tasks. Overall, we observed consistent overlap between the two sets of brain regions, especially in the ATL and TPJ. This supports the claim that tasks involving ToM draw upon more general semantic retrieval processes. We also identified activation specific to ToM in the right TPJ, bilateral anterior mPFC, and right precuneus. This is consistent with the view that, nested amongst more domain-general systems, there is specialised circuitry that is tuned to social processes.
Hypoxia regulate developmental coronary angiogenesis potentially through VEGFR2- and SOX17-mediated signaling
Authors: Vitali Halie E. , Kuschel Bryce , Sherpa Chhiring , Jones Brendan W. , Jacob Nisha , Madiha Syeda A. , Elliott Sam , Dziennik Eddie , Kreun Lily , Conatser Cora , Bhetwal Bhupal P. , Sharma Bikram 
Published: August 2023

AbstractBackgroundCoronary vessels in embryonic mouse heart arises from multiple progenitor population including sinus venosus (SV), endocardium, and proepicardium. ELA/APJ signaling is shown to regulate coronary growth from SV pathway within the subepicardium, whereas VEGF-A/VEGF-R2 pathways is implicated to regulate coronary growth from endocardium pathway. Our previous study show hypoxia as a potential signaling cue to stimulate overall coronary growth and expansion within the myocardium. However, the role of hypoxia and its downstream signaling pathways in the regulation of coronary vessel development is not known. In this study, we investigated the role of hypoxia in coronary vessel development and have identified SOX17- and VEGF-R2-mediated signaling as a potential downstream pathway of hypoxia in the regulation of coronary vessel development.ResultsWe show that hypoxia gain-of-function in the myocardium through upregulation of HIF-1α disrupts the normal pattern of coronary angiogenesis in developing mouse hearts and displays phenotype that is reminiscent of accelerated coronary growth. We show that VEGF-R2 expression is increased in coronary endothelial cells under hypoxia gain-of-functionin vivoandin vitro. Furthermore, we show that SOX17 expression is upregulated in developing mouse heart under hypoxia gain-of-function conditions, whereas SOX17 expression is repressed under hypoxia loss-of-function conditions. Furthermore, our results show that SOX17 loss-of-function disrupts normal pattern of coronary growth.ConclusionCollectively, our data provide strong phenotypic evidence to show that hypoxia might regulate coronary growth in the developing mouse heart potentially through VEGF-R2- and SOX17-mediated downstream signaling pathways.
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
Authors: Wang Qiang , Kim Taehyeung , Martínez-Bonet Marta , Aguiar Vitor R. C. , Sim Sangwan , Cui Jing , Sparks Jeffrey A. , Chen Xiaoting , Todd Marc , Wauford Brian , Marion Miranda C. , Langefeld Carl D. , Weirauch Matthew T. , Gutierrez-Arcelus Maria , Nigrovic Peter A. 
Published: August 2023

AbstractGenome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utilized SNP-seq and bioinformatic enrichment to interrogate 2180 single-nucleotide polymorphisms (SNPs) from 87 SLE risk loci for potential binding of transcription factors and related proteins from B cells. 52 SNPs that passed initial screening were tested by electrophoretic mobility shift and luciferase reporter assays. To validate the approach, we studied rs2297550 in detail, finding that the risk allele enhanced binding to the transcription factor Ikaros (IKZF1), thereby modulating expression ofIKBKE. Correspondingly, primary cells from genotyped healthy donors bearing the risk allele expressed higher levels of the interferon / NF-κB regulator IKKε. Together, these findings define a set of likely functional non-coding lupus risk variants and identify a new regulatory pathway involving rs2297550, Ikaros, and IKKε implicated by human genetics in risk for SLE.
Conformational transitions of the HIV-1 Gag polyprotein upon multimerization and gRNA binding
Authors: Banerjee Puja , Voth Gregory A. 
Published: August 2023

AbstractDuring the HIV-1 assembly process, the Gag polyprotein multimerizes at the producer cell plasma membrane, resulting in the formation of spherical immature virus particles. Gag-gRNA interactions play a crucial role in the multimerization process, which is yet to be fully understood. We have performed large-scale all-atom molecular dynamics simulations of membrane-bound full-length Gag dimer, hexamer, and 18-mer. The inter-domain dynamic correlation of Gag, quantified by the heterogeneous elastic network model (hENM) applied to the simulated trajectories, is observed to be altered by implicit gRNA binding, as well as the multimerization state of the Gag. The lateral dynamics of our simulated membrane-bound Gag proteins, with and without gRNA binding, agree with prior experimental data and help to validate our simulation models and methods. The gRNA binding is observed to impact mainly the SP1 domain of the 18-mer and the MA-CA linker domain of the hexamer. In the absence of gRNA binding, the independent dynamical motion of the NC domain results in a collapsed state of the dimeric Gag. Unlike stable SP1 helices in the six-helix bundle, without IP6 binding, the SP1 domain undergoes a spontaneous helix-to-coil transition in the dimeric Gag. Together, our findings reveal conformational switches of Gag at different stages of the multimerization process and predict that the gRNA binding reinforces an efficient binding surface of Gag for multimerization, as well as regulates the dynamic organization of the local membrane region itself.SignificanceGag(Pr55Gag) polyprotein orchestrates many essential events in HIV-1 assembly, including packaging of the genomic RNA (gRNA) in the immature virion. Although various experimental techniques, such as cryo-ET, X-ray, and NMR, have revealed structural properties of individual domains in the immature Gag clusters, structural and biophysical characterization of a full-length Gag molecule remains a challenge for existing experimental techniques. Using atomistic molecular dynamics simulations of the different model systems of Gag polyprotein, we present here a detailed structural characterization of Gag molecules in different multimerization states and interrogate the synergy between Gag-Gag, Gag-membrane, and Gag-gRNA interactions during the viral assembly process.
Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
Authors: Zhang Wengang , Liu Yonglan , Jang Hyunbum , Nussinov Ruth 
Published: August 2023

AbstractDysregulation of cyclin-dependent kinases (CDKs) impacts cell proliferation, driving cancer. Here, we ask why the cyclin-D/CDK4 complex governs cell cycle progression through the longer G1 phase, whereas cyclin-E/CDK2 regulates the short G1/S phase transition. We consider the experimentally established high-level bursting of cyclin-E, and sustained duration of elevated cyclin-D expression in the cell, available experimental cellular and structural data, and comprehensive explicit solvent molecular dynamics simulations to provide the mechanistic foundation of the distinct activation scenarios of cyclin-D/CDK4 and cyclin-E/CDK2 in the G1 phase and G1/S transition of the cell cycle, respectively. These lead us to propose slower activation of cyclin-D/CDK4 and rapid activation of cyclin-E/CDK2. Importantly, we determine the mechanisms through which this occurs, offering innovative CDK4 drug design considerations. Our insightful mechanistic work addresses the compelling cell cycle regulation question and illuminates the distinct activation speeds in the G1 versus G1/S phases, which are crucial for cell function.StatementOur work provides an unprecedented mechanistic understanding of the distinct activation scenarios of cyclin-D/CDK4 and cyclin-E/CDK2 in cell cycle regulation, underpinning the slower activation of cyclin-D/CDK4 in the more extended G1 phase and the rapid activation of cyclin-E/CDK2 in the brief G1/S transition. Our findings address a long-standing question in cell cycle biology and suggest the design of targeted CDK4 inhibitors.
Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2
Authors: Wang Xia , chen Dawei , guo MengNan , Ning Yao , Guo Jing , Gao Jiahui , Xie Xiaoran , Zhao Dong , Li Lixiang , Li Shiyang , Li Yanqing , Zuo Xiuli , Li Jingxin 
Published: August 2023

AbstractColon cancer is commonly regarded as hormone-independent. However, there have been reports suggesting the involvement of sex hormones in colon cancer development. Nevertheless, the role of hormones from the hypothalamus-hypophysis axis in colitis-associated colorectal cancer (CAC) remains uncertain. In this study, we observed a significant reduction in the expression of the oxytocin receptor (OXTR) in colon samples from both colitis and CAC patients. To investigate further, we generated mice with an intestinal epithelium cell (IEC)-specific knockout of OXTR. These mice exhibited markedly increased susceptibility to dextran sulfate sodium (DSS)-induced colitis and DSS/Azoxymethane (AOM)-induced CAC compared to wild-type mice. Our findings indicate that OXTR depletion impaired the inner mucus of the colon epithelium. Mechanistically, oxytocin was found to regulate MUC2 maturation through B3GNT7-mediated fucosylation. Interestingly, we observed a positive correlation between B3GNT7 expression and OXTR expression in human colitis and CAC colon samples. Moreover, the administration of oxytocin significantly alleviated tumor burden. Hence, our study unveils oxytocin’s promising potential as an affordable and effective therapeutic intervention for individuals affected by colitis and CAC.
Exploring financial inclusion in MENA countries: an entropy weight approach
Authors: Ramaian Vasantha Naveenan , Liew Chee Yoong , Kijkasiwat Ploypailin 
Published: August 2023

Purpose
Research on financial inclusion (FI) in Islamic countries has evolved and gained prominence. This study aims to construct an extensive multidimensional FI index to ascertain the level of inclusion and trends in the Middle East/North Africa (MENA) countries. Additionally, this study examines the potential role of Islamic finance in improving access to financial services.

Design/methodology/approach
Data for the study were collected from databases covering MENA countries for the period 2010–2020. An inclusion index has been constructed using the entropy method.

Findings
Key findings indicate that the overall FI has improved in Islamic countries. However, it should be noted that all MENA countries fall within the low or medium levels of the inclusion index. It was observed that insurance access and penetration savings were poor in the Islamic MENA countries.

Social implications
The authors recommend that policymakers focus on insurance access and saving behaviour in their respective countries. Based upon these observations, policymakers should promote the economic benefits of Islamic finance, which will help improve FI and economic development in Islamic countries. This study emphasises the necessity of policy framework reform to provide Islamic financial services to the poorest in society at low or no cost for better economic benefits.

Originality/value
Most studies tend to overlook important indicators such as insurance, savings and credit penetration while calculating the index. These indicators add value to the existing literature. The majority of prior studies used United Nation Development Programme methodology or principal component analysis for Inclusion Index measurements. The adoption of the entropy weighting method is the novelty of this study.
How big data features drive financial accounting and firm sustainability in the energy industry
Authors: Azzam Mohsen Ebied Abdelghafar Younis , Alsayed Marwa Saber Hamoda , Alsultan Abdulaziz , Hassanein Ahmed 
Published: August 2023

Purpose
This study aims to scrutinize the relationship between the perception of big data (BD) features and the primary outcomes of financial accounting. Likewise, it explores whether financial accounting practices moderate the relationship between BD features and firm sustainability.

Design/methodology/approach
The study used a questionnaire survey based on the Likert scale for two distinct groups of participants: academic scholars and industry practitioners operating in the BD era within the energy sector.

Findings
The results reveal significant positive associations between BD features and firm performance, reporting quality, earnings determinants, fair value measurements, risk management, firm value, the efficiency of the decision-making process, narrative disclosure and firm sustainability. Besides, the path analysis indicates an indirect impact of BD on firm sustainability via financial accounting practices. The results suggest that energy firms should consider incorporating BD analysis into their financial accounting processes to improve their sustainability performance and create long-term value for their stakeholders.

Practical implications
The findings are particularly interesting to academics in accounting and business to improve the accounting curriculums to fit the technological revolution, especially in the field of BD analytics. Practitioners within energy industries must also refine their skills and knowledge to meet the challenges of BD in the foreseeable future. The results provide important implications for policy setters to revise current financial accounting standards to cope with technological innovation.

Originality/value
The study makes a valuable contribution by critically examining the impact of BD on various financial accounting practices neglected in prior research. It highlights the transformative power of BD in the domain of financial accounting and provides insights into its potential implications for energy firms.
Revitalizing reference services and fostering information literacy: Google Bard’s dynamic role in contemporary libraries
Authors: Adetayo Adebowale Jeremy , Oyeniyi Wosilat Omolara 
Published: August 2023

PurposeThis paper aims to explore the transformative potential of Google Bard, an artificial intelligence (AI)-powered chatbot, in reshaping contemporary library reference services and advancing information literacy.Design/methodology/approachIn this perspective piece, a qualitative research approach is used to explore the capabilities of Google Bard within library contexts. Real-world case studies and insights are used to critically examine Bard’s evolving role as a virtual assistant, its impact on enhancing information literacy and the multifaceted challenges it introduces, including biases and privacy concerns.FindingsThe research reveals that Google Bard, leveraging natural language processing and machine learning, engages users in dynamic conversational interactions. It provides contextually relevant responses and personalized guidance, leading to an enriched library experience. The symbiotic relationship between AI-driven technology and traditional librarian expertise is highlighted, contributing to interactive knowledge exploration and collaborative learning.Originality/valueThis study contributes to the literature by exploring the multifaceted impact of Google Bard on library services and information literacy. It uncovers novel insights into the integration of AI-powered chatbots in traditional library settings.
Modeling drivers and barriers of climate change mitigation strategies in Indian iron and steel industry: a TISM-based approach
Authors: Singh Puja , Pradhan Vishal Suresh , Patil Yogesh B. 
Published: August 2023

PurposeThe main purpose of this paper is to investigate drivers and barriers of climate change mitigation strategies (CCMS), their linkages and impact in Indian Iron and Steel Industry (IISI) in light of ninth sustainable development goal (building resilient infrastructure, promote sustainable industrialization and foster innovation).Design/methodology/approachTo identify relevant drivers and barriers, a thorough literature review and opinions of industry experts were obtained. Utilizing Total Interpretive Structural Modeling (TISM), the selected drivers and barriers were modeled separately along with Cross Impact Matrix-multiplication Applied to Classification (MICMAC).FindingsPragmatic and cost-effective technology, less supply chain complexity, robust policy and legal framework were found to have the highest driving power over all the other drivers. Findings suggest political pressure as the most critical barrier in this study. The results from TISM and MICMAC analysis have been used to elucidate a framework for the understanding of policymakers and achieve top management commitment.Practical implicationsThis paper will help researchers, academicians, industry analysts and policymakers in developing a systems approach in prioritizing CCMS in energy-intensive (coal dependent) iron and steel plants. The model outcomes of this work will aid operational research to understand the working principles in other industries as well.Originality/valueTo the best of authors' knowledge, there is paucity of reported literature for the drivers and barriers of CCMS in iron and steel industry. This paper can be considered a unique, first attempt to use data from developing nations like India to develop a model and explain relationships of the existing drivers and barriers of CCMS.