bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABI3BP is a prognosis biomarker related with clinicopathological features and immunity infiltration of lung tumor
Authors: Feng Yan , Han Xiaolei , Zhang Zhe , Qiao Han , Tang Huaping 
Published: January 2023

Background: The primary factor of cancer mortality is lung tumor. ABI3BP gene encodes an extracellular matrix bind protein associated to multiplication and derivation. However, the prognosis score of ABI3BP for lung tumor and its relation with immunity cellular infiltration for lung tumor have not been reported.Methods: Public repository systems (Timer, GEPIA, TCGA, HPA) were utilized to explore expression of ABI3BP for lung tumor, and explored the relation of ABI3BP and clinicopathological parameters. TCGA information set was utilized for cox analysis for data with one or more variables of ABI3BP for lung tumor. STRING was utilized to explore ABI3BP regulatory networks. GO/KEGG enrichment analysis as well as enrichment analysis of gene sets were carried out for ABI3BP co-expression via R package. And finally we explored the relation of expression of ABI3BP and lung tumor immunity invasion, exploring the influence of ABI3BP level of expression on immunotreatment and whether immunity invasion would affect the prognosis of patients with lung tumor.Results: ABI3BP is downregulated in LUAD and LUSC, and associated to lung tumor phase and prognosis. Univariate and multivariate cox regression showed that ABI3BP was an independent prognostic factor in patients with lung tumors. The extracellular matrix protein-coding gene and the ABI3BP-related gene were intersected to obtain 10 hub genes. On the basis of GO/KEGG enrichment analysis, hub genes are closely associated to immunity-associated pathways including T cell receptor signaling pathway, immune response−activating cell surface receptor signaling pathway. Finally, the expression of ABI3BP is closely related to immune cell infiltration and immune cell marker set, and the expression of ABI3BP can help predict the therapeutic effect of immune checkpoint inhibitors and improve the prognosis of patients.Conclusion: ABI3BP could be a new target for lung tumor that could be utilized as a diagnostic and therapeutic tool.
Immunotherapy and tumor mutational burden in cancer patients with liver metastases: A meta and real word cohort analysis
Authors: Wu Rui-Yan , Wang Bi-Cheng , Wang Kun , Xia Fan , Zhang Zhi-Yuan , Wan Jue-Feng , Zhang Zhen 
Published: January 2023

BackgroundThe predictive effects of liver metastases for immune-checkpoint inhibitors (ICIs) and the relationship between tumor mutational burden (TMB) and liver metastases (LM) remain unclear.MethodsA systematic review and meta-analysis were conducted to explore the heterogeneity of ICIs efficacy between patients with or without LM. A pan-cancer cohort of 1,661 patients who received ICIs was downloaded and analyzed to assess the association between TMB and LM.ResultsOf 21053 studies identified in our search, eight single-arm studies and 24 randomized controlled trials were included. Overall, 17957 patients with advanced or metastatic cancers (4805 patients (26.8%) with LM and 13151 patients (73.2%) without LM) were enrolled. The pooled objective response rate (ORR) was 8.5% (95% CI 4%–13%) in the LM group versus 21% (95% CI 16%–21%) in the non-LM group. The pooled hazard ratio (HR) for death was 0.85 (95% CI 0.80–0.90) in the LM group treated with ICIs compared with the standard of care. In patients without LM who were treated with ICIs, the pooled HR for death was 0.78 (95% CI 0.73–0.82) compared with the standard of care. The difference in efficacy between patients with or without LM treated with ICIs was significant (p=0.04). Pan-cancer analysis revealed that the TMB-high rate was 10.8% in liver metastatic lesions versus 21.4% in other metastatic lesions (p=0.004). In addition, TMB was also significantly associated with OS as a binary cutoff (p=0.05) and was an independent prognostic variable (HR=0.98, P=0.047) as a continuous variable in patients with LM.ConclusionsIn patients with LM, the efficacy of immunotherapy was attenuated, but TMB-high could predict better survival outcomes.
Feiyiliu Mixture sensitizes EGFRDel19/T790M/C797S mutant non-small cell lung cancer to osimertinib by attenuating the PRC1/Wnt/EGFR pathway
Authors: Shi Jingjing , Hao Shaoyu , Liu Xiantao , Li Yingying , Zheng Xin 
Published: January 2023

Introduction: Osimertinib is a potent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of acquired resistance due to the EGFR-Del19/T790M/C797S mutation limits the clinical application of osimertinib. Feiyiliu Mixture (FYLM), a clinical experience formula of Chinese medicine, was used to treat lung cancer with good clinical efficacy. In this study, we aimed to investigate the mechanism by which Feiyiliu Mixture delays osimertinib resistance in EGFR-mutant cell lines and EGFR-mutant cell tumor-bearing mice.Methods: The osimertinib-resistant cell models were established in mouse Lewis lung carcinoma (LLC) cells transfected with EGFR-Del19/T790M/C797S mutant lentivirus. In cell experiments, after 48 h of treatment with Feiyiliu Mixture-containing serum, MTT assay was used to detect the relative cell viability, and western blotting was used to detect EGFR protein phosphorylation expression. In animal experiments, C57BL/6J mice were subcutaneously injected with Lewis lung carcinoma cells stably expressing EGFR-Del19/T790M/C797S mutations to construct a xenograft model. After 2 weeks of Feiyiliu Mixture and/or osimertinib treatment, the expression of proliferation-related, apoptosis-related and PRC1/Wnt/EGFR pathway markers was detected by real-time qPCR, western blotting and immunohistochemistry.Results: The results showed that when combined with osimertinib, Feiyiliu Mixture synergistically reduces proliferation and increases apoptosis to improve drug resistance. In vitro, Feiyiliu Mixture-containing serum reduced the EGFR phosphorylation. In vivo, Feiyiliu Mixture downregulated the expression of cyclin B1 and Bcl-2 while upregulating the level of cleaved Caspase-3 protein, indicating that Feiyiliu Mixture promotes apoptosis. Furthermore, Feiyiliu Mixture reduced the expression of p-EGFR, p-Akt, PRC1 and Wnt pathway-related proteins such as β-catenin, c-Myc and c-Jun.Conclusion: The present study identified that Feiyiliu Mixture inhibited PRC1/Wnt/EGFR pathway activation, reduced proliferation, and promoted apoptosis, thereby increasing the sensitivity of EGFR-mutant non-small cell lung cancer to osimertinib. Our study provided a new idea for Chinese medicine to play a role in enhancing efficacy and reducing toxicity in the treatment of non-small cell lung cancer.
Inhalation of virus-loaded droplets as a clinically plausible pathway to deep lung infection
Authors: Chakravarty Aranyak , Panchagnula Mahesh V. , Patankar Neelesh A. 
Published: January 2023

Respiratory viruses, such as SARS-CoV-2, preliminarily infect the nasopharyngeal mucosa. The mechanism of infection spread from the nasopharynx to the deep lung–which may cause a severe infection—is, however, still unclear. We propose a clinically plausible mechanism of infection spread to the deep lung through droplets, present in the nasopharynx, inhaled and transported into the lower respiratory tract. A coupled mathematical model of droplet, virus transport and virus infection kinetics is exercised to demonstrate clinically observed times to deep lung infection. The model predicts, in agreement with clinical observations, that severe infection can develop in the deep lung within 2.5–7 days of initial symptom onset. Results indicate that while fluid dynamics plays an important role in transporting the droplets, infection kinetics and immune responses determine infection growth and resolution. Immune responses, particularly antibodies and T-lymphocytes, are observed to be critically important for preventing infection severity. This reinforces the role of vaccination in preventing severe infection. Managing aerosolization of infected nasopharyngeal mucosa is additionally suggested as a strategy for minimizing infection spread and severity.
The intervention of Brain Gym in the mathematical abilities of high-school students: A pilot study
Authors: Ramos-Galarza Carlos , Aymacaña-Villacreses Cristina , Cruz-Cárdenas Jorge 
Published: January 2023

IntroductionThe learning process of Mathematics is a challenge in Latin America; therefore, it is of vital importance to conduct actions that improve the performance in this science.MethodsThis article is reporting on quasi-experimental research, where, through the use of Brain Gym, the objective is to improve: the definition of rational numbers, problem-solving ability, mathematical order relationships, and equivalent fractions. We worked with 67 students between 12 and 14 years old, organized into an experimental group (n = 35) and a control group (no participation group; n = 32).ResultsWe made pre and post-test measurements and found that the control group students improved in their problem-solving ability F(1,65) = 8.76, p = 0.04, η2 = 0.12 and equivalent fractions F(1,65) = 4.54, p = 0.03, η2 = 0.06.DiscussionIn conclusion, the importance of applying innovative processes to improve the teaching and learning of Mathematics can be affirmed. It is important to note that both the control and experimental groups improved their learning, however, the experimental group did so to a greater extent than the students in the control group, who received a traditional educational process, and they did learn, but not at the level of the experimental group.
Development of social anxiety cognition scale for college students: Basing on Hofmann’s model of social anxiety disorder
Authors: Zha Yuxin , Tang Qin , Jin Xiaoru , Cai Xinfei , Gong Wen , Shao Yongcong , Weng Xiechuan 
Published: January 2023

IntroductionTo develop the Chinese version of the Social Anxiety Cognition Scale for College Students (SACS-CS) based on Hofmann’s model of social anxiety disorder and examine its reliability and validity.MethodsBased on literature analysis and structured interviews, a theoretical model was constructed and behavioral examples were collected. According to the results of participants’ and experts’ evaluations, the initial SACS-CS was developed. The study data were collected from a total of 500 valid participants, randomly divided into two samples. Sample 1 (n = 200) and sample 2 (n = 300) were considered for exploratory factor analysis and confirmatory factor analysis (CFA), respectively. Internal reliability and validity were examined using all 500 participants, and temporal reliability was established using sample 3 (n = 70), who completed the scale again after 4 weeks.ResultsThe SACS-CS consists of 21 items, grouped under four factors: self-perception, social skills, emotional control, and cost estimation. The four-factor model fits well. The internal consistency coefficient of the scale and the four factors ranged from 0.87 to 0.96, and the test–retest reliability ranged from 0.76 to 0.84. The scores of the scale and the four factors were significantly correlated with the score of the Interaction Anxiousness Scale (r = 0.54–0.64).DiscussionThe SACS-CS possesses good reliability and validity and can be applied in the cognitive assessment of college students’ social anxiety. The scale could help people with different social anxiety disorder conditions receive more personalized interventions.
Long-term bidirectional association between asthma and attention deficit hyperactivity disorder: A big data cohort study
Authors: Park Hye Jin , Kim Young Hyeon , Na Da Ye , Jeong Seong Won , Lee Min Gyu , Lee Jong-Hwan , Yang Yun Na , Kang Min Gu , Yeom Sang Woo , Kim Jong Seung 
Published: January 2023

BackgroundPrevious studies have argued that attention deficit hyperactivity disorder (ADHD) is associated with asthma. However, reliable evidence to verify this association has not yet been reported.ObjectivesTo investigate the bidirectional association between asthma and ADHD through a 12-year big data cohort study.MethodsThe independent variable group was extracted from 3.5 million individuals randomly sampled by the National Health Insurance Service (NHIS). In Study 1, the incidence of ADHD according to asthma was evaluated, while in Study 2, the incidence of asthma according to ADHD was analyzed. Propensity score (PS) matching with several variables was used to obtain a control group.Measurements and main resultsIn Study 1, the asthma group included 131,937 individuals and the non-asthma group included 131,937 individuals. The adjusted hazard ratio (aHR) for ADHD in the asthma group was 1.17 [95% confidence interval (CI): 1.11–1.23]. In subgroup analysis, the aHRs for ADHD of individuals in the subgroups male sex, 0–5 years old, 6–10 years old, atopic dermatitis, allergic rhinitis, Charlson comorbidity index (CCI) 1, and CCI &gt; 2 were significant (aHR: 2.83, 1.70, 1.79, 1.09, 1.15, 1.06, and 1.49, respectively). In Study 2, ADHD was found to significantly affect asthma in all age groups (aHRs of the subgroups 0∼60 and 0∼17 years old were 1.10 and 1.09, respectively). In the 0∼17 years old subgroup, the association of ADHD with asthma was greater with younger age (aHRs of the subgroups 0∼5 and 6∼10 years old were 2.53 and 1.54, respectively).ConclusionFrom long-term follow-up, the incidence of ADHD was 1.17 times higher in the asthma group than in the control group. The incidence of asthma was 1.10 times higher in the ADHD group than in the control group. Asthma and ADHD have a bidirectional relationship, and childhood asthma and ADHD should be rigorously managed.
A inter-relação periodontia e dentística observando os tecidos periodontais em restaurações em resina composta - Relato de caso clínico
Authors: Araújo Ingrid Gabrielle dos Santos , Da Costa Caio Hans Simas , De Lima Thiago Mendes 
Published: January 2023

INTRODUÇÃO: A estética em Periodontia é, essencialmente, dependente de dois fatores: saúde e harmonia. Quando a Dentística Restauradora for atuar em lesões cervicais, o contorno gengival e saúde periodontal devem ser considerados. OBJETIVO: Relatar um caso clínico de restauração de lesão cervical não cariosa, em resina composta, preservando os tecidos periodontais. METODOLOGIA: O presente estudo trata de um relato de caso, com um paciente de 29 anos, gênero masculino, queixando-se de halitose, estética e busca de tratamento endodôntico no elemento 22 (incisivo lateral superior esquerdo), após avaliação, foi confirmado que o elemento 22 já foi tratado endodonticamente, e que a halitose estava associada a lesões, diagnosticadas como Lesões Cervicais Não Cariosa (LCNC), relacionadas má oclusão, as mesmas apresentaram indicação para restaurações em resina composta. CONCLUSÃO: O relato de caso, revelou que as lesões cervicais não cariosas são de caráter multifatoriais, mas que quando se realiza um bom diagnostico e um plano de tratamento, respeitando os espaços biológicos, podemos devolver saúde, estética e função para o elemento dental.
Avaliação da reatividade vascular do extrato do caule de <em>Blutaparon portulacoides</em> em aorta isolada de ratos
Authors: Fitz Gustavo Augusto Mota , Macorini Luís Fernando Benitez , Radai Joyce Alencar Santos , Leitão Maicon Matos , Kassuya Cândida Aparecida Leite , Vilela Lazaro Felipe Costa 
Published: January 2023

A modificação da grande prevalência de doenças infecciosas e parasitárias para as doenças crônicas não transmissíveis (DCNT) afeta a qualidade e os hábitos de vida da população. Dentre as (DCNT) a Hipertensão Arterial Sistêmica (HAS) possui grande relevância tendo em vista a prevalência e complicações. Nessa perspectiva, a procura por tratamentos alternativos e/ou complementares junto ao farmacológico vem crescendo consideravelmente, e o uso de plantas medicinais se torna cada vez mais frequente. Analisar os efeitos de plantas medicinais como a Blutaparon portulacoides na reatividade vascular de animais pode ser importante para o início de potencial terapêutico em doenças cardiovasculares. B. portulacoides pertence a família Amaranthaceae sendo nativa em ao longo de todo o litoral do Rio Grande do Sul. Alguns estudos já foram realizados com o extrato dessa planta relatando ação antiinflamatória contra o veneno de cobras do gênero Bothrops.
Exodontia de terceiros molares associado a laser terapia de baixa potência - relato de caso clínico
Authors: Bertoldo Kamilla Pereira , Dos Santos Nayara Caroline Paiva , Varejão Lívia Coutinho 
Published: January 2023

INTRODUÇÃO: A exodontia usual é uma intervenção cirúrgica que ocasiona dano tecidual. Este dano gera uma reação inflamatória que desencadeia o processo da dor, produzida no paciente após uma cirurgia. OBJETIVO: Relatar um caso clínico de exodontia de terceiros molares, utilizando a laserterapia como adjuvante na modulação e analgesia. METODOLOGIA: O presente estudo trata de um relato de caso, com um paciente de 24 anos, gênero feminino, queixando-se de dor nos elementos 18 e 28 (terceiros molares superiores, direito e esquerdo), após avaliação, os mesmos apresentaram indicação para exodontia, realizadas as extrações, foi aplicado o laser de baixa potência. CONCLUSÃO: O relato de caso, revelou que a associação da laserterapia no pós-operatório cirúrgico de terceiros molares, mostrou-se altamente eficiente para diminuição da dor e regeneração local da ferida cirúrgica.
A enfermagem diante da mulher negra vítima de violência
Authors: Da Silva Carlos Daniel Messias , Da Silva Jhessica Tais Ribeiro , Soares Jandson de Oliveira , Pontes Alessandra Nascimento 
Published: January 2023

Por estética de cor/raça e gênero feminino, as mulheres negras brasileiras sofrem veemente múltiplas violências nos mais diversos ambientes, impostas brutalmente por uma sociedade racista e escravocrata. Objetivo: Sendo assim, o objetivo deste artigo é discorrer sobre a atuação da Enfermagem diante das mulheres negras que são submetidas aos mais diversos tipos de violência. Métodos: Este artigo foi elaborado a partir de uma revisão de literatura. Para realização do levantamento de dados científicos, foram realizadas pesquisas nas seguintes bases de dados eletrônicas: Scientific Electronic Library Online (SCIELO), Literatura Internacional em Ciências da Saúde (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Objetivando o levantamento dos artigos, foram utilizados os descritores seguintes: “Violência contra as Mulheres” AND “Atenção integral á mulher” AND “Assistência integral à Saúde” AND “Vulnerabilidade social”, no período de 2018 a 2022. A pesquisa foi realizada entre os meses de setembro e outubro de 2022. Resultados: A partir dos artigos selecionados, houve a discussão entre os respectivos autores sobre questões envolvendo as origens, consequências e assistência de Enfermagem diante da mulher negra vítima de violência. Considerações finais: Faz-se necessário a inclusão de mais políticas públicas em escolas e universidades a cerca do tema, para que objetivem a erradicação de todo e qualquer nível de violência á mulher, bem como o extermínio do preconceito racial que diminui, degride, humilha hipersexualiza e hostiliza a cor negra. Bem como, torna-se extremamente necessário o cumprimento da legislação vigente neste país, que protege vítimas e pune o agente causador da agressão.
Pantallas digitales y síndrome de fatiga ocular en estudiantes de la carrera de enfermeira
Authors: Fernanda Vega Salinas Karla , Cruz Carmen Alicia Llerena 
Published: January 2023

El Síndrome de Fatiga Ocular (SFO), es reconocido por la Organización Internacional del Trabajo (OIT) dentro del grupo de enfermedades laborales, la mayor parte de las personas que usan de forma diaria pantallas digitales son niños y jóvenes que han crecido a la par de la era digital. Por esto es importante analizar el uso de pantallas digitales y el síndrome de fatiga ocular en estudiantes de la carrera de enfermería. El estudio es cuantitativo, de alcance correlacional. El diseño del estudio será de campo no experimental, transversal. La presente investigación será aplicada a 156 estudiantes como muestra. De 156 estudiantes el 53,2% presenta un nivel moderado de sintomatología visual, seguido de un 32,1% con rango severo, continuamente se evidencia que aquellos que tienen un nivel leve (14,7%). En conclusión existe un nivel moderado de los síntomas oculares y visuales (CRVOS) asociados al uso prolongado de pantallas visuales (PVD).
El Cannabis como tratamiento alternativo en pacientes con Fibromialgia
Authors: Aguinsaca Karina Fernanda Pucha , Molina Erika Pamela Abad , Hernández John Paul castillo , Romero Martín Alexander Chamorro , Reinoso Sonia Azucena Ortiz , Sarmiento Chrisy Esthephanye Sarmiento 
Published: January 2023

La Fibromialgia (FM), es un trastorno reumático no articular crónico, causado por la alteración del sistema Nocioceptivo y la activación del sistema de alerta, lo cual genera dolor musculoesquueletico continuo y extenso, la presencia de puntos anatómicos sensibles a presión, y alteraciones neuroendocrinas. Es de difícil diagnóstico y su tratamiento se basa en terapias multidiciplinarias enfocadas a mantener el ritmo de vida del paciente. Sin embargo, el dolor crónico sigue siendo uno de los mayores desafíos, por lo que actualmente se ha propuesto el uso del Cannabis como medicina alternativa en pacientes con Fibromialgia, ya que los ensayos clínicos, han evidenciado efectos analgésicos, antiinflamatorios e inmunomoduladores de dos principios activos del Cannabis, el CBD y el THC. No obstante, las regulaciones estatales y la desinformación son brechas difíciles de tratar para avanzar hacia el uso clinico y seguro de este este narcótico que posee grandes oportunidades de desarrollo.
Avaliação da frequência do consumo de alimentos ultraprocessados por crianças menores de 2 anos
Authors: Silva Priscylla Feitosa 
Published: January 2023

Os hábitos alimentares formados no período de introdução alimentar possuem papel fundamental, pois irão refletir na vida adulta. Nessa fase, recomenda-se que a dieta seja rica em alimentos in natura ou minimamente processados e que se evite alimentos ultraprocessados. Objetivo: Analisar o perfil de consumo de alimentos ultraprocessados por crianças na fase de introdução alimentar a fim de melhorar as orientações dietéticas. Método: Estudo transversal descritivo quantitativo com 92 crianças entre 6 meses e 2 anos incompletos internadas nas enfermarias do Hospital Materno Infantil de Brasília (HMIB). Foi aplicado um Questionário de Frequência Alimentar com 15 itens alimentares subdivididos em 6 categorias de frequência de consumo. Resultados: A maioria dos pacientes possuía idade inferior a 1 ano e 6 meses (81.5%). Iogurte/leite fermentado/petit suisse e biscoito tipo maria/maizena/leite/água e sal foram os alimentos mais consumidos. Papinha pronta e refrigerante foram os menos oferecidos às crianças. Conclusão: Quanto maior a idade da criança, maior a chance dela consumir algum tipo de bebida ou alimento ultraprocessado na fase de introdução alimentar.