bluuebunny/crossref_metadata_2025_split huggingface dataset:
Democrats’ Mistakes and the Birth of Authoritarian Rule: Ramón S. Castillo and the Fall of Conservative Democracy in Argentina
Authors: Taccone Nicolás , López Ignacio A. 
Published: August 2023

AbstractOn 4 June 1943, a military coup crushed Argentina's democracy, marking the end of the oligarchic era and ‘planting the seeds’ of Peronism. This case sheds light on how rulers’ mistakes can operate as a key independent variable in producing regime changes. We argue that the former conservative president, Ramón S. Castillo, provoked an otherwise avoidable democratic breakdown. Specifically, Castillo's misguided relationships with regime insiders and outsiders unintentionally eroded political stability and triggered the fall of democracy. Until now, agent-based scholarship has fallen short in tracing incumbents’ mistakes and linking them to regime-change processes. We test the argument by conducting a within-case analysis of Argentina's democratic fall in the early 1940s, scrutinising the president's errors at five critical events. We conclude that critical-event analysis can help disentangle the role of leaders’ mistakes in other episodes of regime change.
Rich Poverty: 2 Corinthians 8.1–15 and the Social Meaning of Poverty and Wealth
Authors: Barclay John M.G. 
Published: August 2023

AbstractThis article, originally presented as the Presidential Address at the 2022 SNTS Meeting in Leuven, explores the ways in which Paul configures giving and ‘wealth’, both in relation to the Macedonians and Corinthians (as contributors to the Jerusalem collection) and in relation to Christ. Drawing on the dream-interpretations of Artemidorus, it illustrates how ‘wealth’ could be understood in antiquity as performance rather than possession: one is wealthy in giving and not (or not only) in having. In this light, Paul offers a striking image of the Macedonians who in their poverty were ‘rich’ in their unreserved commitment to the collection, fulfilling the dream of the poor by acquiring the dignity of giving. The Christological statement of 2 Cor 8.9 can also be understood (and integrated) in a new way: it was in his wealth (of self-sharing) that Christ became poor (in the weakness of the cross), so that the Corinthians, participating in this momentum, might become ‘rich’ in the same self-giving of Christ. Although grace and money are not identical, neither are they unrelated ‘economies’: the grace of the Christ-event transforms its beneficiaries into givers, rich in multiple forms of generosity, including material gift. The text thus evidences principles of a non-competitive mode of social relations operative in the material sphere, with the capacity to stimulate a theological challenge to dehumanising forms of capitalism.
The Second Teacher's Story in the Infancy Gospel of Thomas: A Contribution to the Recent Discussion on the Developmental Interpretation
Authors: Cielontko David 
Published: August 2023

AbstractThe article explains the problematic Second Teacher episode in the so-called developmental interpretation of IGT recently proposed by M. R. Whitenton and J. R. C. Cousland. The article shows that the killing of the second teacher in the text of Gs, which is appropriately identified as problematic for the developmental interpretation, appears to be a later version of the episode that most likely already sought to supplement a more original account. In the earliest recoverable form, preserved in the early versions (Syriac, Latin and Ethiopic), the story consistently does not blame Jesus for the death of the second teacher, either in the episode itself or in the other passages. So in the earliest surviving version(s), the teacher dies but not because of a curse from Jesus. Therefore, this episode does not disturb the so-called developmental interpretation.
Modelling mass drug administration strategies for reducing scabies burden in Monrovia, Liberia
Authors: Tellioglu Nefel , Chisholm Rebecca H. , Campbell Patricia Therese , Collinson Shelui , Timothy Joseph , Kollie Karsor , Zayzay Samuel , Devine Angela , McVernon Jodie , Marks Michael , Geard Nicholas 
Published: August 2023

Abstract
Scabies is a parasitic infestation with high global burden. Mass drug administrations (MDAs) are recommended for communities with a scabies prevalence of >10%. Quantitative analyses are needed to demonstrate the likely effectiveness of MDA recommendations. In this study, we developed an agent-based model of scabies transmission calibrated to demographic and epidemiological data from Monrovia. We used this model to compare the effectiveness of MDA scenarios for achieving scabies elimination and reducing scabies burden, as measured by time until recrudescence following delivery of an MDA and disability-adjusted-life-years (DALYs) averted. Our model showed that three rounds of MDA delivered at six-month intervals and reaching 80% of the population could reduce prevalence below 2% for three years following the final round, before recrudescence. When MDAs were followed by increased treatment uptake, prevalence was maintained below 2% indefinitely. Increasing the number of and coverage of MDA rounds increased the probability of achieving elimination and the number of DALYs averted. Our results suggest that acute reduction of scabies prevalence by MDA can support a transition to improved treatment access. This study demonstrates how modelling can be used to estimate the expected impact of MDAs by projecting future epidemiological dynamics and health gains under alternative scenarios.
Are There Any Conventional Obligations?
Authors: Monti Ezequiel 
Published: August 2023

AbstractThere are reasons to believe that conventional obligations are impossible. Thus, it could be argued that for me to have an obligation to Φ in virtue of the fact that a convention so requires, it must be the case that I have a convention-independent obligation to do something else such that, given the existence of the convention, Φing is a way of doing just that. But, then, my obligation to Φ would not really be conventional at all. On closer inspection, so-called conventional obligations turn out to be no more than a specification of what our nonconventional obligations require given the circumstances. In this paper, I shall argue that contra to what this argument suggests, there can be genuinely conventional obligations. To do so, I develop a second-personal account of conventional obligations, according to which obligations are grounded by conventions in virtue of an explanation that does not follow the indicated pattern.
Orbital Forcing and Evolution of the Southern African Monsoon From Late Miocene to Early Pliocene
Authors: de Azevedo Allana Queiroz , Jiménez‐Espejo Francisco J. , Bulian Francesca , Sierro Francisco J. , Tangunan Deborah , Takashimizu Yasuhiro , Albuquerque Ana Luiza S. , Kubota Kaoru , Escutia Carlota , Norris Richard D. , Hemming Sidney R. , Hall Ian R. 
Published: August 2023

AbstractThe late Miocene‐early Pliocene (7.4‐4.5 Ma) is a key interval in Earth's history where intense reorganization of atmospheric and ocean circulation occurred within a global cooling scenario. The Southern African monsoon (SAFM) potentially played an important role in climate systems variability during this interval. However, the dynamics of this important atmospheric system is poorly understood due to the scarcity of continuous records. Here, we present an exceptional continuous late Miocene to early Pliocene reconstruction of SAFM based on elemental geochemistry (Ca/Ti and Si/K ratios), stable isotope geochemistry (δ18O and δ13C recorded in the planktonic foraminiferaOrbulina universa), and marine sediment grain size data from the International Ocean Discovery Program (IODP) Site U1476 located at the entrance of the Mozambique Channel. Spectral characteristics of the Si/K ratio (fluvial input) was used to identify the main orbital forcing controlling SAFM. Precession cycles governed precipitation from 7.4 to ∼6.9 Ma and during the early Pliocene. From ∼6.9 to ∼5.9 Ma, the precession and long eccentricity cycles drove the SAFM. The major Antarctic ice sheet expansion across this interval appear to influence the isotopic records ofO. universaimprinting its long‐term variability signal as a response to the ocean and atmospheric reorganization. Precession cycles markedly weakened from 5.9 to 5.3 Ma, almost the same period when the Mediterranean Outflow Water ceased. These findings highlight important teleconnections among the SAFM, Mediterranean Sea, and other tropical regions.
The Influence of Confining Pressure and Preexisting Damage on Strain Localization in Fluid‐Saturated Crystalline Rocks in the Upper Crust
Authors: McBeck Jessica , Cordonnier Benoît , Ben‐Zion Yehuda , Renard François 
Published: August 2023

AbstractThe spatial organization of deformation may provide key information about the timing of catastrophic failure in the brittle regime. In an ideal homogenous system, deformation may continually localize toward macroscopic failure, and so increasing localization unambiguously signals approaching failure. However, recent analyses demonstrate that deformation, including low‐magnitude seismicity, and fractures and strain in triaxial compression experiments, experience temporary phases of delocalization superposed on an overall trend of localization toward large failure events. To constrain the conditions that promote delocalization, we perform a series of X‐ray tomography experiments at varying confining pressures (5–20 MPa) and fluid pressures (0–10 MPa) on Westerly granite cores with varying amounts of preexisting damage. We track the spatial distribution of the strain events with the highest magnitudes of the population within a given time step. The results show that larger confining pressure promotes more dilation, and promotes greater localization of the high strain events approaching macroscopic failure. In contrast, greater amounts of preexisting damage promote delocalization. Importantly, the dilative strain experiences more systematic localization than the shear strain, and so may provide more reliable information about the timing of catastrophic failure than the shear strain.
High Q-factor reconfigurable microresonators induced in side-coupled optical fibres
Authors: Vassiliev Victor , Sumetsky Michael 
Published: August 2023

AbstractHigh Q-factor monolithic optical microresonators found numerous applications in classical and quantum optical signal processing, microwave photonics, ultraprecise sensing, as well as fundamental optical and physical sciences. However, due to the solid structure of these microresonators, attaining the free spectral range tunability of most of them, critical for several of these applications, was, so far, unfeasible. To address this problem, here we experimentally demonstrate that the side-coupling of coplanar bent optical fibres can induce a high Q-factor whispering gallery mode optical microresonator. By changing the curvature radius of fibres from the centimetre order to the millimetre order, we demonstrate fully mechanically reconfigurable optical microresonators with dimensions varying from the millimetre order to 100-micron order and free spectral range varying from a picometre to ten picometre order. The developed theory describes the formation of the discovered microresonators and their major properties in a reasonable agreement with the experimental data. The new microresonators may find applications in cavity QED, microresonator optomechanics, frequency comb generation with tuneable repetition rate, tuneable lasing, and tuneable processing and delay of optical pulses.
T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
Authors: Yang Zhi-Zhang , Kim Hyo Jin , Wu Hongyan , Tang Xinyi , Yu Yue , Krull Jordan , Larson Daniel P. , Moore Raymond M. , Maurer Matthew J. , Pavelko Kevin D. , Jalali Shahrzad , Pritchett Joshua C. , Mudappathi Rekha , Wang Junwen , Villasboas Jose C. , Mondello Patrizia , Novak Anne J. , Ansell Stephen M. 
Published: August 2023

AbstractT-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57+ TFH cells, with a late-stage differentiation phenotype, were significantly more abundant in FL patients who had early disease progression and therefore correlated with an inferior survival. Single cell analysis (CITE-seq) revealed that CD57+ TFH cells exhibited a substantially different transcriptome from CD57− TFH cells with upregulation of inflammatory pathways, evidence of immune exhaustion and susceptibility to apoptosis. Taken together, our results show that different tumor microenvironments among FL patients are associated with variable T-cell phenotypes and an increased prevalence of CD57+ TFH cells is associated with poor patient survival.
Long-term outcomes of allogeneic stem cell transplant in multiple myeloma
Authors: Schmidt Walker M. , Perera Nirosha D. , Buadi Francis K. , Hayman Suzanne R. , Kumar Shaji K. , Dispenzieri Angela , Dingli David , Cook Joselle , Lacy Martha Q. , Kapoor Prashant , Leung Nelson , Muchtar Eli , Warsame Rahma M. , Kourelis Taxiarchis , Binder Moritz , Gonsalves Wilson I. , Hogan William J. , Gertz Morie A. 
Published: August 2023

AbstractAllogeneic stem cell transplant (allo SCT) for multiple myeloma (MM) is potentially curative in some, while toxic in many others. We retrospectively analyzed 85 patients diagnosed with MM who underwent allo SCT as frontline or salvage therapy between 2000 and 2022 at Mayo Clinic Rochester and examined patient outcomes and prognostic markers. Overall survival (OS), progression free survival (PFS), treatment related mortality (TRM), and relapse rates (RR) were estimated using the Kaplan Meier method and competing risk models. Median follow-up was 11.5 years. Median OS and PFS were 1.7 and 0.71 years, respectively. Five-year OS and PFS were 22.2% and 15.1%, respectively. One-year TRM was 23.5%. Twelve patients demonstrated durable overall survival, living 10+ years beyond their allo SCT. This subgroup was more likely to have no or one prior auto SCT (p = 0.03) and to have been transplanted between 2000 and 2010 (p = 0.03). Outcomes were poor in this cohort with long follow-up, with few patients surviving 5 years or more, and most relapsing or dying within 2 years. We would expect better outcomes and tolerability with an expanded array of novel therapeutics and would prefer them to allo SCT.
Ascitic autotaxin as a potential prognostic, diagnostic, and therapeutic target for epithelial ovarian cancer
Authors: Choi Jung-A , Kim Hyosun , Kwon Hyunja , Lee Elizabeth Hyeji , Cho Hanbyoul , Chung Joon-Yong , Kim Jae-Hoon 
Published: August 2023

AbstractBackgroundMalignant ascites contributes to the metastatic process by facilitating the multifocal dissemination of ovarian tumour cells onto the peritoneal surface. However, the prognostic and diagnostic relevance of ascitic fluid remains largely unknown. Herein, we investigated the potential clinical value and therapeutic utility of ascitic autotaxin (ATX) in epithelial ovarian cancer (EOC).MethodsATX expression was assessed in clinical samples. Spheroid-forming assay, real-time PCR, western blot analysis, invadopodia assay, and adhesion assays were performed.ResultsAscitic ATX expression was highly elevated in patients with ovarian cancer compared to those with benign ascites and was associated with advanced stage, high grade, and a short disease-free period in patients with EOC. Combining the diagnostic ability of ascitic ATX and serum CA-125 levels significantly improved the area under the curve (AUC) value for EOC compared to serum CA125 level alone. This marker combination showed a large odds ratio for short disease-free period in high-risk EOC groups. Functional studies revealed that ascitic ATX was required for maintaining cancer stem cell-like characteristics and invadopodia formation.ConclusionAscitic ATX levels may serve as a useful prognostic indicator for predicting aggressive behaviour in EOC. ATX-linked invadopodia are a potential target to prevent peritoneal dissemination in ovarian cancer.
Reactivated endogenous retroviruses promote protein aggregate spreading
Authors: Liu Shu , Heumüller Stefanie-Elisabeth , Hossinger André , Müller Stephan A. , Buravlova Oleksandra , Lichtenthaler Stefan F. , Denner Philip , Vorberg Ina M. 
Published: August 2023

AbstractPrion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigenetically silenced, become upregulated in neurodegenerative diseases such as amyotrophic lateral sclerosis and tauopathies. Here we uncover that activation of endogenous retroviruses affects prion-like spreading of proteopathic seeds. We show that upregulation of endogenous retroviruses drastically increases the dissemination of protein aggregates between cells in culture, a process that can be inhibited by targeting the viral envelope protein or viral protein processing. Human endogenous retrovirus envelopes of four different clades also elevate intercellular spreading of proteopathic seeds, including pathological Tau. Our data support a role of endogenous retroviruses in protein misfolding diseases and suggest that antiviral drugs could represent promising candidates for inhibiting protein aggregate spreading.
High-throughput analysis of Fröhlich-type polaron models
Authors: de Melo Pedro Miguel M. C. , de Abreu Joao C. , Guster Bogdan , Giantomassi Matteo , Zanolli Zeila , Gonze Xavier , Verstraete Matthieu J. 
Published: August 2023

AbstractThe electron–phonon interaction is central to condensed matter, e.g. through electrical resistance, superconductivity or the formation of polarons, and has a strong impact on observables such as band gaps or optical spectra. The most common framework for band energy corrections is the Fröhlich model, which often agrees qualitatively with experiments in polar materials, but has limits for complex cases. A generalized version includes anisotropic and degenerate electron bands, and multiple phonons. In this work, we identify trends and outliers for the Fröhlich models on 1260 materials. We test the limits of the Fröhlich models and their perturbative treatment, in particular the large polaron hypothesis. Among our extended dataset most materials host perturbative large polarons, but there are many instances that are non-perturbative and/or localize on distances of a few bond lengths. We find a variety of behaviors, and analyze extreme cases with huge zero-point renormalization using the first-principles Allen-Heine-Cardona approach.
Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need
Authors: Cherian Neil , Bettis Alison , Deol Arminder , Kumar Arun , Di Fabio Jose Luis , Chaudhari Amol , Yimer Solomon , Fahim Raafat , Endy Timothy 
Published: August 2023

AbstractChikungunya is an arboviral disease caused by the chikungunya virus (CHIKV) afflicting tropical and sub-tropical countries worldwide. It has been identified as a priority pathogen by the Coalition for Epidemics Preparedness Innovations (CEPI) and as an emerging infectious disease (EID) necessitating further action as soon as possible by the World Health Organization (WHO). Recent studies suggest that disability-adjusted life years (DALYs) due to CHIKV infection are as high as 106,089 DALYs lost globally. Significant progress has been made in the development of several vaccines, aimed at preventing CHIKV infections. This perspective article summarizes CEPI’s efforts and strategic considerations for developing a CHIKV vaccine and ensuring equitable access for CHIKV endemic countries.
One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression
Authors: Sasaki Masato , Yamamoto Kazuo , Ueda Takeshi , Irokawa Hayato , Takeda Kouki , Sekine Ryoya , Itoh Fumie , Tanaka Yutaka , Kuge Shusuke , Shibata Nobuyuki 
Published: August 2023

AbstractTumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor. We focused on aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which metabolizes 10-fTHF to tetrahydrofolate and whose expression is often attenuated in hepatocellular carcinoma (HCC). We generated ALDH1L1-expressing HuH-7 cells to perform metabolome analysis and found that intracellular levels of serine were reduced and glycine was increased. In addition, 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP), a dnPS intermediate, accumulated due to the consumption of 10-fTHF by ALDH1L1, which inhibited ZMP formylation. Importantly, ALDH1L1-expressing cells showed reduced ZMP sensitivity and higher mitochondrial activity. The suppression of mitochondrial serine catabolism by ALDH1L1 expression was speculated to be closely related to this phenotype. Gene set enrichment analysis utilizing The Cancer Genome Atlas data revealed that genes related to oxidative phosphorylation were enriched in HCC patients with high ALDH1L1 expression. Moreover, drug sensitivity data analysis demonstrated that HCC cell lines with low expression of ALDH1L1 were sensitive to ZMP and cordycepin, a structural analog of ZMP and AMP. Our study revealed that ZMP and AMP analogs might be effective in the pharmacotherapy of HCC patients with low expression of ALDH1L1.
Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation
Authors: Astasov-Frauenhoffer Monika , Göldi Livia , Rohr Nadja , Worreth Sarah , Dard Elise , Hünerfauth Selina , Töpper Tino , Zurflüh Jonas , Braissant Olivier 
Published: August 2023

AbstractControlling biofilm formation in the oral cavity during orthodontic treatments is crucial. Therefore, antimicrobial surfaces for invisible dental appliances are of interest to both therapists and patients. Here we present a cellulose-based thermoformable material used for invisible braces that can be loaded with essential oils (EOs) having antibacterial and antifungal properties. We hypothesize that this material can absorb and release EOs, thus providing an antimicrobial effect without compromising the safety and mechanical properties necessary for dental invisible braces. Conventional microbiology and isothermal microcalorimetry analyses revealed that the thermoformable material loaded with essential oils significantly delayed the biofilm formation of oral streptococci (S. mutans and S. mitis) under static conditions (p < 0.05) and while simulating saliva flow (p < 0.05). In addition, cytotoxicity tests (ISO 10993-5), revealed that the loaded material is well tolerated by human gingival fibroblasts. Finally, the loading with antibacterial agents did not significantly alter the mechanical properties and stability of the material (initial force (p = 0.916); initial stress (p = 0.465)). Compared to gold-standard clear aligner materials, this material offers a reliable transmission of forces for orthodontic treatments. Moreover, this approach exhibits the potential for acting as an oral drug delivery platform for multiple compounds.