bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuberculosis in patients with underlying thalassemia
Authors: Sriwijitalai Won , Wiwanitkit Viroj 
Published: May 2023

Background
Tuberculosis is a common medical problem in the present day. The occurrence of this infection among the patients with congenital underlying disease is very interesting. Here, the authors study on the common pathways regarding the antioxidative process of tuberculosis and thalassemia, a congenic hemoglobin disorder.

Materials and methods
This work is a bioinformatics expressional analysis. The authors performed common pathway analysis and interrelationship identification for expressional pathways regarding antioxidative process of tuberculosis and thalassemia.

Results
The common pathway via glutathione can be shown and imply the increased risk for tuberculosis among the patients with underlying thalassemia.

Conclusion
Based on identified common antioxidative pathway, patients with thalassemia might be prone to acquire tuberculosis infection.
Incidence of respiratory complications in obese adult patients after cardiac surgeries
Authors: El Assal Mohamed A. , Essawy Tarek S. , El Gazar Mohamed A. , Rezk Moataz E. , Hani Basma M. , Ghabn Hossiny E. 
Published: May 2023

Introduction
Patients experience multiple alterations in respiratory function physiology and mechanics owing to intubation, mechanical ventilation, and cardiopulmonary bypass during cardiac surgery and during getting off cardiopulmonary bypass. Obesity is one of the growing epidemic problems, with increased cardiovascular disease risk and mortality in the USA. The WHO in 2010 assigned Egypt as one of African countries where obesity problem is prevalent, as 70% of its population are obese, the authors investigated the hypothesis that obese patients are more liable to respiratory complication after cardiac surgery.

Patients and methods
This cohort observational study was done on 50 patients admitted to the postoperative critical care unit, who were classified according to BMI into two groups. Group 1 included nonobese patients with BMI 18–25, and group 2 included obese patients with BMI more than 30.

Results
The authors found that there was a highly statistically significant difference between both groups regarding weight and BMI (P<0.001). There is a highly statistically significant difference between the two studied groups regarding pH, PCO2, total leukocyte count, and occurrence of chest infection (P<0.001). There were no significant statistical differences between both groups regarding PO2 parameter and occurrence of other pulmonary complications.

Conclusion
The authors conclude that there is a highly statistically significant strong positive association between BMI and chest infection, where the risk of chest infection increases with increase in BMI.
Epidemiological, clinical and radiological patterns of interstitial lung diseases at cardiothoracic Minia University Hospital
Authors: Said Azza F. , Abdel-Kader Basma M. , Abu-Samra Manal F. , Saeed Zainab H. , Abdel-Kader Moustafa , Kasem Ahmed H. 
Published: May 2023

BackgroundInterstitial lung diseases (ILDs) have undergone significant evolution in recent years. Clinical epidemiological data on ILDs from Egypt are limited. We performed this research to assess the epidemiological, clinical, and radiological patterns of ILDs at a single center for 1-year duration.Patients and methodsAn observational cohort study was performed on 100 patients of ILDs. Patients’ demographic, clinical examination, spirometry, 6-min walk test, collagen profile, and high-resolution computed tomography of the chest data were collected.ResultsA total of 100 patients with ILDs were studied, and 77 of them were females. The mean age of the patients was 48 years, 88% of them from rural areas, and ∼50% of them were housewives with significant exposure to bird breeding. The distribution of ILD cases was hypersensitivity pneumonitis (HP) (51%) followed by idiopathic interstitial pneumonia (26%), unclassifiable ILD (13%), and lastly, connective tissue disease associated with ILD (10%). Most of the clinical features had nearly an equal distribution among the different types of ILDs (P>0.05). Regarding radiological pattern on high-resolution computed tomography chest, it was found that ground-glass opacity was the only pattern that had a significant occurrence in patients with HP than other subtypes.ConclusionApproximately half of the studied patients had HP, so attention to those exposed patients is an important element for early diagnosis of HP as the most common subtype of ILD.
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea
Authors: El Wassefy Mona , Sabry Mariam , Rlshafey Mohsen , Hamad Ahmed M. , Suliman Lucy A. 
Published: May 2023

Background
Obstructive sleep apnea syndrome (OSAS) is associated with the respiratory tract inflammation. Fractional exhaled nitric oxide (FeNO) and high-sensitivity C-reactive protein (Hs-CRP) are indicators of airway and systemic inflammation. Few revisions have explored the effect of continuous positive airway pressure (CPAP) on both indicators in OSAS.

Purpose
To study the influence of CPAP therapy on exhaled NO and Hs-CRP in OSAS.

Patients and methods
This is a case–control study that included 27 participants with OSAS and 10 controls enlisted from a sleep outpatient clinic. Full-night polysomnography was performed, and the next morning, FeNO and Hs-CRP were evaluated. CPAP for patients with moderate to severe OSA was advised with measurement of FeNO and Hs-CRP after 3 months of CPAP.

Results
Both FeNO and Hs-CRP in patients with OSA were statistically significantly increased against the control group. However, after 3 months of CPAP therapy, there was a statistically significant decrease in both FeNO and Hs-CRP.

Conclusion
Upper airway and systemic inflammation are extant in OSAS, reinforced by increases in both FeNO and CRP, and CPAP therapy diminishes FeNO levels in patients with OSA.
Changing the airway pH
Authors: Rezk Nasef Abd-Elsalam , Alshamy Ahmed , Shehta Mohamed , Morsy Nesreen Elsyed , Alnahas Mohamed 
Published: May 2023

Background
Although airway hyperacidity may have a great effect in the pathogenesis of asthma, its evaluation may be difficult. This study was conducted at Mansoura University Hospitals aiming to evaluate the degree of asthma control by increasing pH in uncontrolled asthma cases by the use of inhaled NaHCO3 8.4% for 3 months.

Patients and methods
A total of 100 patients with asthma were included, and they were divided by simple randomization to 75 patients in study group and 25 controls. All participants were subjected to history taking, clinical examination, sputum cell count and pH assessment, PFT, high-resolution computed tomography, and sputum induction and NaHCO3 8.4% inhalation. Evaluation of asthma exacerbation 6 months before and after intervention was carried out.

Results
There was no significant difference between study and control groups regarding demographic data, all basic investigations, pulmonary function, or sputum total and differential cells. We found a significant increase of sputum pH after treatment in the study group. Furthermore, significant improvement of forced expiratory volume in 1 s, forced vital capacity, four parameters of control assessment, and exacerbation also was seen in the study group after treatment. There was a significant decrease of total cells and eosinophils in sputum in the study group. The linear regression model showed a significant negative correlation for all the studied factors except short-acting beta 2 (SABA) and day symptom improvement.

Conclusion
We conclude that the decrease of airway acidity by NaHCO3 8.4% leads to significant decrease in inflammatory cells and frequency of exacerbation and improves pulmonary function in poorly controlled bronchial asthma.
Indian Community's Knowledge, Attitude, and Practice toward COVID-19
Authors: Tomar Balvir Singh , Singh Pratima , Nathiya Deepak , Suman Supriya , Raj Preeti , Tripathi Sandeep , Chauhan Dushyant Singh 
Published: May 2023

Background:
The COVID-19 pandemic has caused unprecedented human health consequences. It is imperative to understand the society's awareness toward knowledge, attitude, and practice (KAP) level and the extent of measures required by health authorities.

Aims and Objective:
The aim of the study was to assess the KAP of the general public of India on COVID-19. In this study, a web-based cross-sectional survey was conducted between March 10 and April 18, 2020. Materials and Method: A 19-item questionnaire was generated using Google Forms and distributed through social media networks via snowball sampling technique. The Chi-square test was used to compare categorical data, and multiple linear regression was used to identify factors influencing KAP. Result: Among 7978 participants, the overall KAP score was 80.64%, 97.33%, and 93.8%, respectively. In multiple linear regression analysis, male gender (β = 0.036: P < 0.001), urban population (β = 0.006: P < 0.002), higher education (β = 0.029: P < 0.001), and higher occupation (β = 0.002: P = 0.05) were associated significantly with high knowledge score. There was a positive significant correlation between knowledge and attitude, knowledge and practice, and attitude and practice.

Conclusion:
The KAP level among the general public was adequate, however there is a necessity to target specific category population with tailored health education program to ameliorate the level of knowledge and attitude. knowledge and attitude.
Assessing the Quality of Life Among Nonfatal Road Traffic Accident Victims by using WHO-QOL-BREF
Authors: Mishra Suchismita , Babu Bontha V , Marimuthu Palaniappan 
Published: May 2023

Background/Objectives:
Road traffic accident affects people more in terms of disability with prolonged treatment than premature death. More people suffer from nonfatal injuries, with many incurring a disability as a result of their injury. The study aims to report the quality of life among nonfatal road traffic accident victims of Karnataka state, India.

Methodology:
Consecutive data of 6 years (2013–2018) on road traffic injuries of the state of Karnataka were collected from the States Crimes Records Bureau of Karnataka. The contact details of victims categorized as nonfatal were traced out. Finally, 286 nonfatal cases were selected as respondents. Data were collected using WHO-QOL-BREF questionnaire to measure the quality of life.

Results:
The better quality of life in all the four domains, that is, physical health, psychological health, social relationships, and environmental health, was found among the less injured category of victims. There was a statistically significant difference (P < 0.05) among the different categories of accidents as well as the types of postaccident occupation of the respondents for all the four domains. A significant variation was found across different age groups for the physical health domain. Respondents of below 18 years were found with the better mean score for all the domains. Similar differences are observed for education for all the domains, except the social relation domain. The Mann–Whitney U-test revealed a significant difference between those who received the compensation and those who did not receive the compensation for the psychological domain.

Conclusions:
The study warrants policy-related measures with ease of compensation procedures by simplifying the insurance processes and counseling. Indeed, rehabilitation measures need to be taken seriously by the government as the support system is vital for the improvement for quality of life among road traffic accident victims.
Basic Functioning and Resilience in Families of Adolescents with Intellectual Disability and Psychosis
Authors: Chandra Manisha , Bhattacharjee Dipanjan , Das Basudeb , Pachori Hariom 
Published: May 2023

Background:
Family functions and resilience (hardiness) are two important aspects of families for keeping them stable. How those two aspects are present and operate in families having adolescents with mental retardation and psychosis is the aim of this study.

Materials and Methods:
A total of 45 adolescents (comprising 15 intellectually disabled adolescents, 15 adolescents with psychosis [schizophrenia and bipolar disorder], and 15 normal adolescents) and one of the key relatives of each adolescent were selected purposively. One key caregiver of each adolescent in all the three groups was selected, and the McMaster Family Assessment Device and the Family Hardiness Index were applied on them to collect data on family functioning and hardiness.

Results:
Families of the first two groups have reported problems in family functions. No difference could be seen in the family resilience among these three groups of families.

Conclusion:
Families with mentally retarded and psychotic adolescents have family problems; however, both the families show resilience against the stress of having mentally retarded or psychotic adolescents.
Coping Styles in Parents of Children with Thalassemia in West Bengal
Authors: Biswas Daliya , Lo Sourav , Sarkar Aditya Prasad , Mondal Tanushree , Haldar Dibakar , Saha Indrajit 
Published: May 2023

Background:
Thalassemia is stress inducing, and the parents of the affected child develop a variety of coping strategies in response to that stress.

Objective:
The objective of this study was to find coping styles adopted by parents of thalassemic children and to identify factors associated with their coping.

Materials and Methods:
This cross-sectional survey was conducted in 2016–2017 involving 96 randomly selected parents of thalassemic children attending the Thalassemia Clinic of Bankura Sammilani Medical College and Hospital. Data were collected via interview using predesigned questionnaire and Brief-COPE inventory. Analyses were done estimating mean and proportion and using Pearson correlation coefficient (r), unpaired t-test, analysis of variance, and multiple linear regressions.

Results:
Two third of participants were mothers (66.7%) accompanying thalassemic children. Majority of them were aged within 21–30 years (55.2%), Hindu (84.4%), rural inhabitants (96.9%) and belonged to backward class (60.4%). Majority (72.9%) were from joint family of lower socioeconomic strata (94.8%). The age of thalassemic children was 80.47 ± 42.49 (mean±sd) months. Most of them were male (53.1%). Majority of thalassemic children was born in first birth order (63.0%) and diagnosed before attaining first birthday (71.0%). More than 60% of the participants were using acceptance coping “a lot.” The most commonly used coping strategies were active coping, acceptance, planning, and religion. In multivariable analyses, overall coping was found to increase by 0.331 on every unit decrease of age at diagnosis of thalassemia of children and to decrease by 0.116 unit on every unit increase of age of respondents.

Conclusion:
Acceptance coping was used effectively rather than behavioral disengagement, which suggests that a positive attitude toward stress is present but needs to be better handled. Counseling and psychotherapy for parents of thalassemic children can be provided through an intervention program.
Combined intralesional platelet-rich plasma and intralesional steroid versus intralesional steroid alone in the treatment of alopecia areata
Authors: Hamza Ashraf , Elsayed Asmaa , Abdel-Bary Ahmed 
Published: May 2023

Background
Platelet-rich plasma (PRP) is a promising treatment method of alopecia, but there is a debate about its role in the treatment of alopecia areata. Intralesional steroid is the first-line treatment option for patchy alopecia areata. Combination therapy represents an option for increasing the efficacy of the different lines of treatment.

Objective
To compare the therapeutic efficacy of traditional treatment of alopecia areata with intralesional injection of triamcinolone acetonide versus combination therapy with intralesional triamcinolone acetonide and intralesional PRP alternatively.

Patients and methods
In this comparative randomized single-blinded study, 30 patients with two nonadjacent patches of alopecia areata were included. One patch was treated with intralesional triamcinolone acetonide alone (group I) every 4 weeks for 3 months, and the other patch was treated with intralesional triamcinolone acetonide alternating with intralesional PRP (group II) every 2 weeks for 3 months. Evaluation was done by MacDonald Hull and Norris grading and dermoscopy.

Results
A significant increase in the mean grading score was noted before each intralesional steroid injection session in both groups. However, group II patches treated with intralesional triamcinolone acetonide alternating with intralesional PRP showed significantly higher mean grading score as compared with group I patches treated with intralesional triamcinolone acetonide alone. The dermoscopic features of alopecia areata significantly decrease or disappear at the end of treatment sessions in both groups.

Conclusion
Combined use of intralesional steroid and intralesional PRP in the treatment of alopecia areata yields better results than using intralesional steroid alone and could be considered as a more effective line of treatment. However, further research studies are needed to determine the optimal dose, intervals, and duration of treatment.
Comparison of the Dosimetric Benefits of Two Different Three-dimensional Conformal Radiotherapy Treatment Approaches for Postmastectomy Radiotherapy
Authors: Makkapati Bharat , Lobo Dilson , Krishna Abhishek , Athiyamaan M. S. , Banerjee Sourjya , Srinivas Challapalli , Sunny Johan 
Published: May 2023

ABSTRACT

Introduction:
Breast cancer is the most common cancer among women in urban areas in India, which is treated with external beam radiotherapy as a part of a multimodality treatment approach. Delivering external beam radiation therapy to the chest wall and nodal basins is challenging because of the anatomical morphology of the chest wall as well as the near proximity of critical structures. In the current study, we aim to compare the dose volumetric histograms of different organs at risk (OAR) and target volume in carcinoma breast patients whose supraclavicular field is included for radiation therapy using two different three-dimensional conformal radiotherapy (3D-CRT) techniques.

Materials and Methods:
All patients received a prescribed dose of 50 Gy to the postmastectomy chest wall and nodal basins in 25 fractions. Patients underwent standard computed tomography simulation at 3.5 mm slice spacing, in the supine position. Then, patient clinical target volume (CTV) was created using GEC-ESTRO guidelines, and planning target volume was created with an institution-specific margin around CTV. OAR parameters assessed using dose-volume histograms obtained using treatment planning techniques are compared in terms of the ipsilateral lung (V 5, V 10, V 20, V 30, and mean dose), contralateral lung (V 5, V 10, V 20, V 30, and mean dose), heart (V 5, V 25, max, mean, and minimum dose), esophagus (V 35, V 50, and mean dose), contralateral breast (V 5, D 5, minimum, maximum, and mean dose), and spinal cord doses (maximum dose).

Results:
Technique 1 and Technique 2 3D-CRT treatment plans were clinically comparable for postmastectomy radiotherapy (PMRT). Technique 1 plans showed significantly better dose coverage and minimum dose to the spinal cord. On the other hand, Technique 2 plans showed significantly better sparing of normal tissues.

Conclusion:
The choice of radiotherapy technique in PMRT is a very important factor in the protection of neighboring normal structures and the identification of associated risks. Technique 1 can provide significantly superior dose coverage and minimum dose to the spinal cord, whereas Technique 2 offers better sparing of normal tissues.
PENGARUH ARUS KAS OPERASI DAN LABA AKUNTANSI TERHADAP RETURN SAHAM PADA PERUSAHAAN LQ- 45 DI BURSA EFEK INDONESIA PERIODE 2018-2020
Authors: Halawa Ediman Imani Hati , Halawa Derima , Harianja Hotriado 
Published: May 2023

Pentingnya Return saham bagi para investor karena merupakan salah satu faktor yang memotivasi investor untuk berinvestasi dan merupakan bentuk imbalan dan keberanian investor dalam mengambil resiko, Perhatian utama para investor dalam suatu perusahaan adalah menganalisis laporan keuangan terutama pada laba akuntansi dan arus kas operasi. Tujuan penelitian ini untuk mengetahui Pengaruh Arus Kas Operasi dan Laba Akuntansi terhadap Return saham pada perusahaan LQ-45 periode 2018-2020dengan menggunakan data sekunder yang diperoleh dari laporan keuangan tahunan perusahaan dalam Indonesia Stock Exchange (IDX) atau www.idx.co.id. pengambilan sampel dengan tehnik Purpusive Sampling,dari 45 perusahaan populasi maka diperoleh 23 sampel penelitian. Menganalisis data menggunakan statistik deskriptif, dan terlebih dahulu di uji dengan asumsi klasik, dan metode analisa yang dipergunakan adalah regresi linier berganda. Berdasarkan pengujian t disimpulkan bahwa Arus kas operasi tidak berpengaruh signifikan terhadap return saham dan Laba akuntansi berpengaruh signifikan terhadap return saham. Sedangkan secara bersama-sama (uji F) peroleh bahwa Arus Kas Operasi dan Laba Akuntansi Berpengaruh signifikan terhadap return saham.
Perbandingan Metoda K-NN, Random Forest dan 1D CNN untuk Mengklasifikasi Data EEG Eye State
Authors: Rachmatullah Muhammad Ibnu Choldun , Wicaksono Aryaputra , Putratama Virdiandry 
Published: May 2023

The use of machine learning / machine learning methods is very important in developing identification of the status of the human eye, especially in terms of processing Electroencephalogram (EEG) signals to identify eye status. In previous research the method used can be a combination method between supervised learning and unsupervised learning, or a single method using supervised learning. In this study, the EEG Eye State classification uses a single method with supervised learning, namely using the following methods: K-nearest neghbors (k-NN), random forest, and 1D Convolutional Neural Networks (1D CNNs). The performance of the three classifier methods is measured using four measures, namely: accuracy, recall, precision, and F1-Score. From the experimental results it was found that the k-NN method has the best performance compared to the other two methods in terms of the four measures used, where the value of each measure is: accuracy = 82.30%; recall=82.30%; precision= 82.36%; and F1-Score=82.30%. K-NN is more suitable for classifying EEG Eye State than the other two methods, because all input attributes are from the dataset. has a data type of real numbers.
Analisis Bimbingan Belajar dengan Metode Mueulang dalam meningkatkan Prestasi Santri di Dayah Darul Ulum Alue Awe Kota Lhokseumawe
Authors: Ramazana Ramazana , Sa'adah Nurus 
Published: May 2023

Dalam penelitian ini, peneliti ingin mengkaji tentang Bimbingan Belajar Santri dengan metode mueulang untuk meningkatkan kamampuan santri dalam mengkaji kitap kalsik di Dayah Darul Ulum Alue Awe Kota Lhokseumawe, dayah (pondok pasantren) adalah institusi pendidikan keagamaan yang masih mempertahankan tradisi kultural dalam sistem pendidikan keagamaan dalam kirikulum yang masih mempertahankan kajian kitab klasik (kitab gundul, kuning) yang menjadi rujukan keilmuan, penelitian ini ingin meneliti tentang model layanan, kendala dan kelebihan bimbingan belajar yang terdapat dalam metode mueulang di dayah dengan menggunakan metologi penelitian kualitatif desktiptif untuk megkaji fenomena yang terdapat di dalamnya. Hasil penelitian metode mueulang terdapat 2 (dua) model layanan bimbingan belajar yaitu bimbingan individual dan bimbingan kelompok. Suatu bimbingan belajar yang diterapkan tentu ada yang namanya kendala dalam pelaksanaannya, kendala yang terdapat dalampenerapan bimbingan belajar dengan metode mueulang di Dayah Darul Ulum yaitu waktu, partisipasi, dan menejemen, Kelebian yang terdapat dalam pelaksanaanbimbingan belajar metode mueulang dalam meningkatkan prestasi santri di Dayah Darul Ulum dapat menumbuhkan kesukarelaan, keakraban, toleransi, keuletan, dan kekompakan.