bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidation Responsive PEGylated Polyamino Acid Bearing Thioether Pendants for Enhanced Anticancer Drug Delivery
Authors: Sun Yitao , Zhang Yu , Guo Xin , Wang Yanping , He Pan , Xiao Chunsheng 
Published: January 2023

AbstractReactive oxygen species (ROS) in biological tissues are in a state of dynamic balance. However, many diseases such as cancer and inflammation, are accompanied by a long‐term increase in ROS. This situation inspires researchers to use ROS‐sensitive nanocarriers for a site‐specific release of cargo in pathological areas. Polyamino acid materials with good biodegradability, biocompatibility, and regular secondary structure are widely used in the biomedical field. Herein, a new oxidation responsive PEGylated polyamino acid is synthesised for anticancer drug delivery by ring‐opening polymerisation of N‐carboxyanhydrides bearing thioether pendants. The obtained block copolymer mPEG‐b‐PMLG self‐assembles into spherical nanoparticles (NPs) in water with diameter ≈68.3 nm. NMR measurement demonstrated that the hydrophobic thioether pendants in the NPs can be selectively oxidised to hydrophilic sulfoxide groups by H2O2, which will lead to the disassociation of NPs. In vitro drug release results indicated that the encapsulated Nile red is selectively released in the trigger of 10 mM H2O2 in PBS. Finally, anticancer drug doxorubicin (DOX) is encapsulated to the NPs, and the obtained NPs/DOX exhibits an improved antitumor efficacy in 4T1 tumour‐bearing mice and lower cardiotoxicity than free DOX. These results indicates that the mPEG‐b‐PMLG NPs are promising for anticancer drug delivery.
Oxidation of Monoterpenes to Form Diols and Triols: A Versatile Toolbox for Polymer Synthesis
Authors: Fowler Harriet R. , O'Brien Dara M. , Keddie Daniel J. , Alexander Cameron , Irvine Derek J. , Stockman Robert A. , Howdle Steven M. , Taresco Vincenzo 
Published: January 2023

AbstractPolyols and polyacrylates have a wide range of applications in polymer synthesis as monomers, initiators, or building blocks in a variety of polymerization reaction types. With an ever‐growing need to reduce the global dependency on fossil fuels, finding bio‐based/renewable sources for these compounds is now critical. Herein, the alkene moieties of common, abundant terpenes are functionalized via oxidation to expand the “toolbox” of bio‐based diols and triols. These polyol compounds are readily converted into the corresponding terpene‐derived diacrylates using mild conditions. As a proof of concept, it is demonstrated that these monomers can be used in aza‐Michael polymerizations, forming new (bio)degradable poly‐β‐amino esters.