bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in default mode network connectivity in healthy aging adults
Authors: Ficek-Tani Bronte , Horien Corey , Ju Suyeon , Xu Wanwan , Li Nancy , Lacadie Cheryl , Shen Xilin , Scheinost Dustin , Constable Todd , Fredericks Carolyn 
Published: December 2022

AbstractWomen show an increased lifetime risk of Alzheimer’s disease (AD) compared with men. Characteristic brain connectivity changes, particularly within the default mode network (DMN), have been associated with both symptomatic and preclinical AD, but the impact of sex on DMN function throughout aging is poorly understood. We investigated sex differences in DMN connectivity over the lifespan in 595 cognitively healthy participants from the Human Connectome Project-Aging cohort. We used the intrinsic connectivity distribution (a robust voxel-based metric of functional connectivity) and a seed connectivity approach to determine sex differences within the DMN and between the DMN and whole brain. Compared with men, women demonstrated higher connectivity with age in posterior DMN nodes and lower connectivity in the medial prefrontal cortex. Differences were most prominent in the decades surrounding menopause. Seed-based analysis revealed higher connectivity in women from the posterior cingulate to angular gyrus, which correlated with neuropsychological measures of declarative memory, and hippocampus. Taken together, we show significant sex differences in DMN subnetworks over the lifespan, including patterns in aging women that resemble changes previously seen in preclinical AD. These findings highlight the importance of considering sex in neuroimaging studies of aging and neurodegeneration.
Gating at cortical level contributes to auditory-motor synchronization during repetitive finger tapping
Authors: Guo Yaqiu , Zheng Huixian , Long Jinyi 
Published: December 2022

Abstract
Sensory integration contributes to temporal coordination of the movement with external rhythms. How the information flowing of sensory inputs is regulated with increasing tapping rates and its function remains unknown. Here, somatosensory evoked potentials to ulnar nerve stimulation were recorded during auditory-cued repetitive right-index finger tapping at 0.5, 1, 2, 3, and 4 Hz in 13 healthy subjects. We found that sensory inputs were suppressed at subcortical level (represented by P14) and primary somatosensory cortex (S1, represented by N20/P25) during repetitive tapping. This suppression was decreased in S1 but not in subcortical level during fast repetitive tapping (2, 3, and 4 Hz) compared with slow repetitive tapping (0.5 and 1 Hz). Furthermore, we assessed the ability to analyze temporal information in S1 by measuring the somatosensory temporal discrimination threshold (STDT). STDT increased during fast repetitive tapping compared with slow repetitive tapping, which was negatively correlated with the task performance of phase shift and positively correlated with the peak-to-peak amplitude (% of resting) in S1 but not in subcortical level. These novel findings indicate that the increased sensory input (lower sensory gating) in S1 may lead to greater temporal uncertainty for sensorimotor integration dereasing the performance of repetitive movement during increasing tapping rates.
Improved Linear Cryptanalysis of Block Cipher BORON
Authors: Lv Yin , Shi Danping , Hu Lei , Guo Zihui , Guo Yi , Wang Caibing 
Published: December 2022

Abstract
BORON is a lightweight substitution–permutation network cipher proposed in 2017. We reduce the number of guessed key bits by key-bridging technology and first utilize Fast Walsh Transform on BORON to minimize the time complexity. Finally, this paper gives the better key-recovery attack against block cipher BORON than previously proposed by 2 rounds: we realize a 11-round key-recovery attack on BORON-80 and 13-round key-recovery attack on BORON-128. The attacks proposed in this paper are the best attacks against BORON-80/128 to date.
Development and validation of a condition-specific quality of life instrument for adults with esophageal atresia: the SQEA questionnaire
Authors: ten Kate Chantal A , Teunissen Nadine M , van Rosmalen Joost , Kamphuis Lieke S , van Wijk Michiel P , Joosten Maja , van Tuyll van Serooskerken E Sofie , Wijnen René , IJsselstijn Hanneke , Rietman André B , Spaander Manon C W 
Published: December 2022

Abstract
The importance of multidisciplinary long-term follow-up for adults born with esophageal atresia (EA) is increasingly recognized. Hence, a valid, condition-specific instrument to measure health-related quality of life (HRQoL) becomes imperative. This study aimed to develop and validate such an instrument for adults with EA. The Specific Quality of life in Esophageal atresia Adults (SQEA) questionnaire was developed through focus group-based item generation, pilot testing, item reduction and a multicenter, nationwide field test to evaluate the feasibility, reliability (internal and retest) and validity (structural, construct, criterion and convergent), in compliance with the consensus-based standards for the selection of health measurement instruments guidelines. After pilot testing (n = 42), items were reduced from 144 to 36 questions. After field testing (n = 447), three items were discarded based on item-response theory results. The final SQEA questionnaire (33 items) forms a unidimensional scale generating an unweighted total score. Feasibility, internal reliability (Cronbach’s alpha 0.94) and test–retest agreement (intra-class coefficient 0.92) were good. Construct validity was discriminative for esophageal replacement (P &lt; 0.001), dysphagia (P &lt; 0.001) and airway obstruction (P = 0.029). Criterion validity showed a good correlation with dysphagia (area under the receiver operating characteristic 0.736). SQEA scores correlated well with other validated disease-specific HRQoL scales such as the GIQLI and SGRQ, but poorly with the more generic RAND-36. Overall, this first condition-specific instrument for EA adults showed satisfactory feasibility, reliability and validity. Additionally, it shows discriminative ability to detect disease burden. Therefore, the SQEA questionnaire is both a valid instrument to assess the HRQoL in EA adults and an interesting signaling tool, enabling clinicians to recognize more severely affected patients.
Measuring the thickness and Young’s modulus of the ice pack with DAS, a test case on a frozen mountain lake
Authors: Nziengui-Bâ Destin , Coutant Olivier , Moreau Ludovic , Boué Pierre 
Published: December 2022

SUMMARY
We explored the potential of fibre optics coupled with distributed acoustic sensing (DAS) to measure the thickness and Young’s modulus of an ice layer, using the properties of guided seismic waves. During two winter seasons (2020 and 2021), an optical fibre was deployed over one of the frozen Roberts Mountain lakes (at 2400 m a.s.l) near Grenoble (France) and we measured both the continuous ambient seismic noise as well as signals generated by active sources (hammer), with a DAS interrogator. Following a Bayesian scheme, we inverted the dispersion curves of longitudinal and flexural guided waves retrieved from the analysis of active shot gathers and obtained Young’s modulus E = 3.4 ± 0.1 GPa and ice thickness h = 47 ± 1 cm from the second-year data. The ice thickness was consistent with field measurements. Field observations of porous and/or fracture ice may explain the relatively low effective Young’s modulus (relative to pure ice), which may also be affected by a snow layer not included in the model. The drastic improvements in the inversion results between the two years are related to better coupling conditions (drone deployment before early freezing), more appropriate acquisition parameters (2 m gauge length), and the upper snow layers (less thick and less heterogeneous in the second year). Moreover, we were able to use the non-dispersive low-frequency noise associated with gravity waves to estimate the lake depth H = 5 m which is compatible with independent observations. The use of DAS to record guided seismic waves could then appear as a relevant tool for monitoring environments like floating ice shelves and sea ice.
On the potential of offshore sensors and array processing for improving seismic event detection and locations in the North Sea
Authors: Jerkins Annie Elisabeth , Köhler Andreas , Oye Volker 
Published: December 2022

SUMMARY
The capability to detect and locate seismicity in the North Sea is necessary to ensure the safety of future CO2 storage operations. Currently, the event location capabilities are hampered by a one-sided network configuration, as only sensors deployed on the Norwegian mainland are providing good signal-to-noise ratios. However, applying array processing techniques to groups of offshore sensors deployed at oil and gas reservoirs can improve the signal-to-noise ratio at such sites, which generally suffer from high noise contamination originating from platforms or seismic shooting. In this study we test the feasibility of array processing to sensors deployed at the Grane oil field to improve earthquake event locations. Out of the 3400 nodes installed, we have access to two data subsets: (i) continuous data from 10 sensors spread out over the whole field and (ii) short segments of data from 30 sensors selected with the purpose to apply array methods. As the average interstation distance between the 10 sensors is 6 km, the recorded wavefield is not coherent and traditional array processing methods are not applicable. To optimize the usage of the 10-sensor offshore data for event location purposes, we develop a new method for incoherent array processing. We compute a characteristic function based on the kurtosis of the seismic traces prior to a frequency–wavenumber analysis. This method successfully determines slowness and backazimuth for almost all the evaluated earthquakes in this study. Using common coherent array processing, the 30 sensors show superior detection capabilities over the 10 sensors and will therefore decrease the detection threshold for seismic events in the region significantly if continuous data are available. We conclude that offshore sensors at Grane can be included as a part of a system for passive seismic monitoring in the North Sea. We recommend using the 30-sensors data for this purpose. However, as we only have access to continuous data from the 10 sensors in this study, we found that they are a good substitute when the 30-sensor data are not available.
Functional analysis of germlineRAD51Cmissense variants highlight the role of RAD51C in replication fork protection
Authors: Kolinjivadi Arun Mouli , Chong Siao Ting , Choudhary Ramveer , Sankar Haresh , Chew Ee Ling , Yeo Claresta , Chan Sock Hoai , Ngeow Joanne 
Published: December 2022

AbstractMonoallelic or biallelic RAD51C germline mutations results in chromosome instability disorders such as Fanconi anemia and cancers. The bona fide function of RAD51C is to assist RAD51 nucleoprotein filament onto single-strand DNA to complete homologous recombination (HR) repair. In addition to HR repair, the role of RAD51C in DNA replication is emerging when replication forks are transiently or irreversibly stalled. We identified novel RAD51C variants of uncertain significance (VUS) from breast, ovarian, pancreatic and gastric cancer patients and functionally characterized the effect of these variants in replication fork protection and double-strand breaks (DSB’s) repair. In RAD51C-deficient Chinese hamster CL-V4B cells, expression of RAD51C F164S, A87E, L134S and E49K variants heightened sensitivity to mitomycin C (MMC), etoposide and PARP inhibition. Differently, expression of subset of RAD51C variants R24L, R24W and R212H displayed mild sensitivity to MMC, etoposide and PARP inhibition. Further functional characterization of a subset of variants revealed that Rad51C F164S, A87E, L134S and E49K variants displayed reduced RAD51 foci formation and increased overall nuclear single strand DNA levels in the presence of replication stress. Additionally, DNA fiber assay revealed that RAD51C F164S, A87E, L134S and E49K variants displayed defective replication fork protection upon prolonged fork stalling. Investigations using patient-derived lymphoblastoid cell line carrying heterozygous RAD51C L134S variant showed an impairment in RAD51 chromatin association and replication fork protection, suggestive of deleteriousness of this VUS variant. Overall, our findings provide more insights into molecular roles of RAD51C in replication fork integrity maintenance and in DSB repair.
Vitamin D3 andLactobacillus rhamnosusGG/p40 Synergize to Protect Mice From Colitis by Promoting Vitamin D Receptor Expression and Epithelial Proliferation
Authors: Chen Dan , Tang Hao , Li Yue , Yang Hong , Wang Hongying , Tan Bei , Qian Jiaming 
Published: December 2022

AbstractBackgroundWhile vitamin D (VitD) levels are negatively correlated with inflammatory bowel disease (IBD) activity, VitD supplementation does not reduce IBD severity. The probiotic Lactobacillus rhamnosus GG (LGG), which secretes p40, can upregulate colonic VitD receptor (VDR) expression. We therefore evaluated synergy between VitD3 and LGG/p40 in the treatment of mouse colitis.MethodsA dextran sulfate sodium (DSS) colitis model was established in Vdr+/+ and Vdr-/- mice, and mice were treated with VitD3, LGG, or p40 alone or in combination for 7 to 14 days. Colitis severity was assessed by weight loss, disease activity index (DAI), colon length, histology, and inflammatory cytokine expression together with VDR expression, proliferation, and apoptosis. In vitro, VDR expression and cell viability were assessed in HCT116 cells after stimulation with p40.ResultsTotal and nuclear VDR protein expression were lower in DSS-treated Vdr+/+ mice compared with control mice (P &lt; .05). Compared with the DSS group, VitD3 + LGG alleviated colitis as assessed by significantly improved DAI and histological scores, increased colon length, decreased colonic Tnf, and increased Il10 expression together with increased colonic VDR gene and protein expression and increased Ki-67 proliferation index (P &lt; .05). In Vdr-/- mice, VitD3 + LGG had no effect on DSS colitis. In Vdr+/+ mice, VitD3 + p40 also reduced colitis severity according to clinicopathological and immunological metrics and increased VDR expression and epithelial proliferation (P &lt; .05). In HCT116 cells, p40 stimulation increased VDR protein expression and viability (P &lt; .05).ConclusionsVitD3 and LGG/p40 synergistically improve the severity of colitis by increasing colonic VDR expression and promoting colonic epithelial proliferation.
Coupling scientific and local ecological knowledge network models for temperate coastal ecosystems
Authors: Vilalta-Navas Ainoa , Beas-Luna Rodrigo , Zetina-Rejón Manuel J , López-Ibarra Gladis A , Malpica-Cruz Luis , Lorda Julio , Zepeda-Dominguez José Alberto , Kluger Lotta Clara 
Published: December 2022

Abstract
There is an urgent need to analyse and understand small-scale fisheries environment under biotic and abiotic stressors. In this work, we use a kelp forest ecosystem in Baja California, Mexico to present a novel approach, comparing two network models based on different information sources. First, we developed a conventional scientific knowledge network model (CSK) parameterized with in-situ observations. Second, we used a local ecological knowledge network model (LEK) based on interviews with local fishers. Our main objectives were: (a) verify if the two knowledge sources generated comparable models, and (b) explore model responses to disturbance scenarios. The CSK model presented greater detail at lower trophic levels, contrary to the LEK model. Additionally, we simulated top-down and bottom-up ecological disturbances. With a top-down disturbance, the groups’ abundance increased following a cascade effect whereas, in the bottom-up disturbance, changes did not transfer uniformly. We also simulated anthropogenic disturbances through fishing pressure on three target species (lobsters, sea urchins, and sea bass). Our findings show similar patterns with the highest degree of change when lobsters are removed. Our findings highlight the potential of model complementarity and support the relevance of ecological network models to navigate future climate and anthropogenic uncertainty.
Is Aging a Disease? The Theoretical Definition of Aging in the Light of the Philosophy of Medicine
Authors: Saborido Cristian , García-Barranquero Pablo 
Published: December 2022

AbstractIn the philosophical debate on aging, it is common to raise the question of the theoretical definition of aging in terms of its possible characterization as a disease. Understanding aging as a disease seems to imply its medicalization, which has important practical consequences. In this paper, we analyze the question of whether aging is a disease by appealing to the concept of disease in the philosophy of medicine. As a result of this analysis, we argue that a pragmatist approach to the conception of disease is the best alternative to highlight the relevance of the medicalization of aging. From this pragmatist perspective, it can be seen that the notion of aging is going through a conceptual change, and aging can today be understood as a not radically different process from any other condition that is usually considered a disease.
Pathologizing Ugliness: A Conceptual Analysis of the Naturalist and Normativist Claims in “Aesthetic Pathology”
Authors: Aquino Yves Saint James 
Published: December 2022

AbstractPathologizing ugliness refers to the use of disease language and medical processes to foster and support the claim that undesirable features are pathological conditions requiring medical or surgical intervention. Primarily situated in cosmetic surgery, the practice appeals to the concept of “aesthetic pathology”, which is a medical designation for features that deviate from some designated aesthetic norms. This article offers a two-pronged conceptual analysis of aesthetic pathology. First, I argue that three sets of claims, derived from normativist and naturalistic accounts of disease, inform the framing of ugliness as a disease. These claims concern: (1) aesthetic harms, (2) aesthetic dysfunction, and (3) aesthetic deviation. Second, I introduce the notion of a hybridization loop in medicine, which merges the naturalist and normative understanding of the disease that potentially enables pathologizing practices. In the context of cosmetic surgery, the loop simultaneously promotes the framing of beauty ideals as normal biological attributes and the framing of normal appearance as an aesthetic ideal to legitimize the need for cosmetic interventions. The article thus offers an original discussion of the conceptual problems arising from a specific practice in cosmetic surgery that depicts ugliness as the disease.
Modeling news recommender systems’ conditional effects on selective exposure: evidence from two online experiments
Authors: Knudsen Erik 
Published: December 2022

AbstractUnder which conditions do news recommender systems (NRSs) amplify or reduce selective exposure? I provide the Recommender Influenced Selective Exposure framework, which aims to enable researchers to model and study the conditional effects of NRSs on selective exposure. I empirically test this framework by studying user behavior on a news site where the choice environment is designed to systematically influence selective exposure. Through two preregistered online experiments that simulate different NRSs and unobtrusively log user behavior, I contribute empirical evidence that an NRS can increase or decrease the chance that selective exposure occurs, depending on what the NRS is designed to achieve. These insights have implications for ongoing scholarly debates on the democratic impact of NRSs.
The Power of Positive Thinking: How Positive Opinions of Refugees’ Impact on the Host Society Generate Positive Behavioural Intentions
Authors: Korol Liliia , Bevelander Pieter 
Published: December 2022

AbstractMuch prior research has focused on understanding how host nationals’ negative opinions of the impact of migration and arriving communities affect their attitudes towards newcomers. Yet, the role of host nationals’ positive opinions has remained largely underinvestigated. The present study aims to move beyond the negative intergroup paradigm and contribute to the literature by examining whether positive opinions of refugees’ impact on the host society are related to host nationals’ positive behavioural intentions towards them. Specifically, the study investigated (1) the mediating role of social proximity in the relationship between positive opinions of refugees’ impact and readiness to assist them and (2) symbolic and realistic threats as potential moderators that might influence this direct/indirect relationship. The results provide initial evidence of the important role of positive opinions of refugees’ impact on the host community in promoting positive behavioural intentions towards newcomers via indirect association with closer social proximity. Moreover, our findings suggest that this relationship might be particularly beneficial for host nationals who perceive immigrants as imposing a realistic threat to their lives and to society as a whole—individuals who tend to be amongst the most prejudice-prone and resistant to change.
Non-photochemical quenching of photosystem I as an adaptive response to prolonged drought
Authors: Arellano Juan B 
Published: December 2022

This article comments on:Sapeta H, Yokono M, Takabayashi A, Ueno Y, Cordeiro AM, Hara T, Tanaka A, Akimoto S, Oliveira MM, Tanaka R. 2023. Reversible down-regulation of photosystems I and II leads to fast photosynthesis recovery after long-term drought in Jatropha curcas. Journal of Experimental Botany 74, 336–351.
Reorganization of three-dimensional chromatin architecture inMedicago truncatulaunder phosphorus deficiency
Authors: Wang Tianzuo , Wang Jing , Chen Li , Yao Jiaying , Yuan Zan , Zhang Dong , Zhang Wen-Hao 
Published: December 2022

AbstractEmerging evidence reveals that the three-dimensional (3D) chromatin architecture plays a key regulatory role in various biological processes of plants. However, information on the 3D chromatin architecture of the legume model plant Medicago truncatula and its potential roles in the regulation of response to mineral nutrient deficiency are very limited. Using high-resolution chromosome conformation capture sequencing, we identified the 3D genome structure of M. truncatula in terms of A/B compartments, topologically associated domains (TADs) and chromatin loops. The gene density, expressional level, and active histone modification were higher in A compartments than in B compartments. Moreover, we analysed the 3D chromatin architecture reorganization in response to phosphorus (P) deficiency. The intra-chromosomal cis-interaction proportion was increased by P deficiency, and a total of 748 A/B compartment switch regions were detected. In these regions, density changes in H3K4me3 and H3K27ac modifications were associated with expression of P deficiency-responsive genes involved in root system architecture and hormonal responses. Furthermore, these genes enhanced P uptake and mobilization by increasing root surface area and strengthening signal transduction under P deficiency. These findings advance our understanding of the potential roles of 3D chromatin architecture in responses of plants in general, and in particular in M. truncatula, to P deficiency.