bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical analysis of three techniques of suspensionplasty after trapeziectomy: a cadaveric study
Authors: Lui Hayman , Galbraith John G. , Meyers Kathleen , Bindra Randy , Lee Steve K. 
Published: July 2023

The aim of the present cadaveric study was to assess resistance to first metacarpal subsidence of three techniques of suspensionplasty after trapeziectomy. In total, 18 forearms (mean age 60 years [range 20–89]) were used with six specimens per surgical technique: palmar oblique ligament reconstruction with tendon interposition (LRTI), abductor pollicis longus (APL) suspensionplasty, or suture suspensionplasty. There was no significant difference in mean trapezial space height after trapeziectomy and suspensionplasty compared to the preoperative trapezial height. However, after simulation of physiological lateral pinch, there was a significant ( p < 0.05) difference in mean trapezial space height between the APL suspensionplasty and the suture suspensionplasty compared to the LRTI group. After axial loading, there was significantly greater metacarpal subsidence in the LRTI group compared to the APL and suture suspensionplasty groups but no statistically significant difference between the suture suspensionplasty and the APL suspensionplasty groups. Level of evidence: V
Confirmatory Factor Analysis and Measurement Invariance of the Functional Assessment of Cancer Therapy Lung Cancer Utility Index (FACT-LUI)
Authors: Swan J. Shannon , Langer Michelle M. 
Published: July 2023

Background. A portion of the Functional Assessment of Cancer Therapy-Lung (FACT-L) instrument contributed to a previously published utility index, the FACT Lung Utility Index or FACT-LUI. Six FACT items representing lung cancer quality of life covered fatigue, pain, dyspnea, cough, anxiety, and depression. Two FACT items had been previously combined by the index authors into one for nausea and/or appetite loss, resulting in 7 final domains. Methods. The objective was to perform measurement invariance testing within a confirmatory factor analysis (CFA) framework to support the feasibility of using the FACT-LUI for non–preference-based psychometric applications. The original index patients comprised group 1, and similar FACT patient data ( n = 249) from another published study comprised group 2. One 2-factor model and two 1-factor CFA models were evaluated to assess measurement invariance across groups, using varying degrees of item parceling and a small number of residual covariances, all justified by the literature. Results. The 1-factor models were most optimal. A 1-factor model with 1 pair of items parceled showed invariance to the partial scalar level using usual fit criteria across groups, requiring 2 unconstrained intercepts. A 1-factor model with 3 pairs of justified parcels showed full configural, metric, and scalar invariance across groups. Conclusions. The FACT-LUI items fit a partially to fully invariant 1-factor model, suggesting feasibility for non–preference-based applications. Implications. Results suggest useful incorporation of the FACT-LUI into clinical trials with no substantial increased respondent burden, allowing preference-based and other psychometric applications from the same index items. Highlights This work suggests that in addition to being originally designed for use as a utility index, the 7 FACT-LUI items together also fit simple CFA and measurement invariance models. This less expected result indicates that these items as a group are also potentially useful in non–preference-based applications. Clinical trials can make for challenging decisions concerning which patient-reported outcome measures to include without being burdensome. However, the literature suggests a need for improved reporting of quality of life in lung cancer in particular as well as cancer in general. Inclusion of more disease-specific items such as the FACT-LUI may allow for information gathering of both preference-based and non–preference-based data with less demand on patients, similar to what has been done with some generic instruments.
Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases
Authors: Zou Yixuan , Hou Xuefeng , Anegondi Neha , Negahdar Mohammadreza , Cheung Dorothy , Belloni Paula , de Crespigny Alex , Coimbra Alexandre Fernandez 
Published: July 2023

BackgroundIdentifying systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients at risk of more rapid forced vital capacity (FVC) decline could improve trial design. The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.MethodsThis retrospective study used data from patients who were not treated with investigational drugs with and without background antifibrotic therapies in tocilizumab phase 3 SSc, lebrikizumab phase 2 IPF, and zinpentraxin alfa phase 2 IPF studies conducted from 2015 to 2021. Controlled HRCT axial volumetric multidetector computed tomography scans were evaluated using the Imbio LTA tool. Associations between HRCT metrics and FVC slope were assessed through the Spearman correlation coefficient and adjusted R2in a linear regression model adjusted by demographics and baseline clinical characteristics.ResultsA total of 271 SSc and IPF patients were analysed. Correlation coefficients of highest magnitude were observed in the SSc study between the extent of ground glass, normal volume, quantification of interstitial lung disease, reticular pattern, and FVC slope (−0.25, 0.28, −0.28, and −0.33, respectively), while the correlation coefficients observed in IPF studies were in general <0.2. The incremental prognostic value of the baseline HRCT metrics was marginal after adjusting baseline characteristics and was inconsistent across study arms.ConclusionData from the SSc and IPF studies suggested weak to no and inconsistent correlation between quantitative HRCT metrics derived by the Imbio LTA tool and FVC slope in the studied SSc and IPF population.
Factors contributing to healthcare professionals’ adaptive capacity with hospital standardization: a scoping review
Authors: Tsandila-Kalakou Foteini , Wiig Siri , Aase Karina 
Published: July 2023

Abstract
Background
Certain factors contribute to healthcare professionals’ adaptive capacities towards risks, challenges, and changes such as attitudes, stress, motivation, cognitive capacity, group norms, and teamwork. However, there is limited evidence as to factors that contribute to healthcare professionals’ adaptive capacity towards hospital standardization. This scoping review aimed to identify and map the factors contributing to healthcare professionals’ adaptive capacity with hospital standardization.

Methods
Scoping review methodology was used. We searched six academic databases to September 2021 for peer-reviewed articles in English. We also reviewed grey literature sources and the reference lists of included studies. Quantitative and qualitative studies were included if they focused on factors influencing how healthcare professionals adapted towards hospital standardization such as guidelines, procedures, and strategies linked to clinical practice. Two researchers conducted a three-stage screening process and extracted data on study characteristics, hospital standardization practices and factors contributing to healthcare professionals’ adaptive capacity. Study quality was not assessed.

Results
A total of 57 studies were included. Factors contributing to healthcare professionals’ adaptive capacity were identified in numerous standardization practices ranging from hand hygiene and personal protective equipment to clinical guidelines or protocols on for example asthma, pneumonia, antimicrobial prophylaxis, or cancer. The factors were grouped in eight categories: (1) psychological and emotional, (2) cognitive, (3) motivational, (4) knowledge and experience, (5) professional role, (6) risk management, (7) patient and family, and (8) work relationships. This combination of individual and group/social factors decided whether healthcare professionals complied with or adapted hospital standardization efforts. Contextual factors were identified related to guideline system, cultural norms, leadership support, physical environment, time, and workload.

Conclusion
The literature on healthcare professionals’ adaptive capacity towards hospital standardization is varied and reflect different reasons for compliance or non-compliance to rules, guidelines, and protocols. The knowledge of individual and group/social factors and the role of contextual factors should be used by hospitals to improve standardization practices through educational efforts, individualised training and motivational support. The influence of patient and family factors on healthcare professionals’ adaptive capacity should be investigated.

Trial registration
Open Science Framework (https://osf.io/ev7az) https://doi.org/10.17605/OSF.IO/EV7AZ.
Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study
Authors: Boshen Yang , Yuankang Zhu , Xinjie Zheng , Taixi Li , kaifan Niu , Zhixiang Wang , Juan Song , Junli Duan , Suiji Li , Xia Lu , Chengxing Shen 
Published: July 2023

Abstract
Background
Triglyceride-glucose (TyG) index is an efficient indicator of insulin resistance and is proven to be a valuable marker in several cardiovascular diseases. However, the relationship between TyG index and cardiac arrest (CA) remains unclear. The present study aimed to investigate the association of the TyG index with the occurrence and clinical outcomes of CA.

Methods
In this retrospective, multicenter, observational study, critically ill patients, including patients post-CA, were identified from the eICU Collaborative Research Database and evaluated. The TyG index for each patient was calculated using values of triglycerides and glucose recorded within 24 h of intensive care unit (ICU) admission. In-hospital mortality and ICU mortality were the primary clinical outcomes. Logistic regression, restricted cubic spline (RCS), and correlation analyses were performed to explore the relationship between the TyG index and clinical outcomes. Propensity score matching (PSM), overlap weighting (OW), and inverse probability of treatment weighting (IPTW) were adopted to balance the baseline characteristics of patients and minimize selection bias to confirm the robustness of the results. Subgroup analysis based on different modifiers was also performed.

Results
Overall, 24,689 critically ill patients, including 1021 patients post-CA, were enrolled. The TyG index was significantly higher in patients post-CA than in those without CA (9.20 (8.72–9.69) vs. 8.89 (8.45–9.41)), and the TyG index had a moderate discrimination ability to identify patients with CA from the overall population (area under the curve = 0.625). Multivariate logistic regression indicated that the TyG index was an independent risk factor for in-hospital mortality (OR = 1.28, 95% CI: 1.03–1.58) and ICU mortality (OR = 1.27, 95% CI: 1.02–1.58) in patients post-CA. RCS curves revealed that an increased TyG index was linearly related to higher risks of in-hospital and ICU mortality (P for nonlinear: 0.225 and 0.271, respectively). Even after adjusting by PSM, IPTW, and OW, the TyG index remained a risk factor for in-hospital mortality and ICU mortality in patients experiencing CA, which was independent of age, BMI, sex, etc. Correlation analyses revealed that TyG index was negatively correlated with the neurological status of patients post-CA.

Conclusion
Elevated TyG index is significantly associated with the occurrence of CA and higher mortality risk in patients post-CA. Our findings extend the landscape of TyG index in cardiovascular diseases, which requires further prospective cohort study.
A novel strategy for l-arginine production in engineered Escherichia coli
Authors: Nie Mengzhen , Wang Jingyu , Zhang Kechun 
Published: July 2023

Abstract
Background
l-arginine is an important amino acid with applications in diverse industrial and pharmaceutical fields. n-acetylglutamate, synthesized from l-glutamate and acetyl-CoA, is a precursor of the l-arginine biosynthetic branch in microorganisms. The enzyme that produces n-acetylglutamate, n-acetylglutamate synthase, is allosterically inhibited by l-arginine. l-glutamate, as a central metabolite, provides carbon backbone for diverse biological compounds besides l-arginine. When glucose is the sole carbon source, the theoretical maximum carbon yield towards l-arginine is 96.7%, but the experimental highest yield was 51%. The gap of l-arginine yield indicates the regulation complexity of carbon flux and energy during the l-arginine biosynthesis. Besides endogenous biosynthesis, n-acetylglutamate, the key precursor of l-arginine, can be obtained by chemical acylation of l-glutamate with a high yield of 98%. To achieve high-yield production of l-arginine, we demonstrated a novel approach by directly feeding precursor n-acetylglutamate to engineered Escherichia coli.

Results
We reported a new approach for the high yield of l-arginine production in E. coli. Gene argA encoding n-acetylglutamate synthase was deleted to disable endogenous biosynthesis of n-acetylglutamate. The feasibility of external n-acetylglutamate towards l-arginine was verified via growth assay in argA− strain. To improve l-arginine production, astA encoding arginine n-succinyltransferase, speF encoding ornithine decarboxylase, speB encoding agmatinase, and argR encoding an arginine responsive repressor protein were disrupted. Based on overexpression of argDGI, argCBH operons, encoding enzymes of the l-arginine biosynthetic pathway, ~ 4 g/L l-arginine was produced in shake flask fermentation, resulting in a yield of 0.99 mol l-arginine/mol n-acetylglutamate. This strain was further engineered for the co-production of l-arginine and pyruvate by removing genes adhE, ldhA, poxB, pflB, and aceE, encoding enzymes involved in the conversion and degradation of pyruvate. The resulting strain was shown to produce 4 g/L l-arginine and 11.3 g/L pyruvate in shake flask fermentation.

Conclusions
Here, we developed a novel approach to avoid the strict regulation of l-arginine on ArgA and overcome the metabolism complexity in the l-arginine biosynthesis pathway. We achieve a high yield of l-arginine production from n-acetylglutamate in E. coli. Co-production pyruvate and l-arginine was used as an example to increase the utilization of input carbon sources.
Clinical significance of matrix metalloproteinase-9 expression in papillary thyroid carcinoma: a meta-analysis
Authors: Wen Jinxu , Qin Xiaoru , Zhang Jiayi , Wu Xiaoyong , Yan Xuemin , Lu Kewen , Yang Pei , Ji Shuaichong , Zhao Xiangdong , Wang Yuexin 
Published: July 2023

Abstract
Objective
The purpose of this study was to investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and pathological indexes in papillary thyroid carcinoma (PTC).

Evidence obtained
The database was searched in PubMed, Embase, CNKI, and Web of Science databases for relevant clinical trials. The odds ratio (OR) and 95% confidence interval (CI) show the effect of MMP-9 expression and age, tumour size, gender, lymph node metastasis (LNM), and TNM (tumour, lymph node, metastasis) stage. Statistical analysis of the data was performed using Stata 17.0.

Evidence synthesis
A total of 1433 patients with PTC were included in this meta-analysis. MMP-9 expression was significantly correlated with LNM (OR = 3.92, 95% CI = 2.71–5.65, P = 0.000), tumour size (OR = 1.69, 95% CI = 1.13–2.52, P = 0.011), and TNM stage (OR = 2.95, 95% CI = 2.10–4.13, P = 0.000), but not with gender (OR = 0.90, 95% CI = 0.66–1.22, P = 0.487) and age (OR = 1.36, 95% CI = 0.93–1.98, P = 0.115).

Conclusions
Our meta-analysis showed that MMP-9 was significantly associated with LNM, tumour size, and TNM stage; therefore, MMP-9 may be a reliable prognostic biomarker for patients with PTC. However, more high-quality studies are needed to support these findings further.
Massive, life-threatening hemoptysis due to localized granulomatosis with polyangiitis
Authors: Coviello Eleonora , Puma Francesco , Pourmolkara Domenico , Mandarano Martina , Napolitano Antonio Giulio 
Published: July 2023

AbstractMassive hemoptysis may be related to a wide spectrum of diseases whose differential diagnosis can be challenging, also due to the medical emergency condition.We present a case of a 33-year-old woman presented to our department with sudden, life-threatening hemoptysis from unknown etiology, which required a rescue pulmonary lobectomy after resuscitation maneuvers. Histology proved to be a localized Wegener granulomatosis. Our case shows that granulomatosis should always be considered among the possible, although rarer, causes of massive hemoptysis.
The relationship between patient safety culture and adverse events in Iranian hospitals: a survey among 360 nurses
Authors: Moosavi Saeideh , Amerzadeh Mohammad , Azmal Mohammad , Kalhor Rohollah 
Published: July 2023

AbstractBackgroundAdverse events have become a global problem and are an important indicator of patient safety. Patient safety culture is essential in efforts to reduce adverse events in the hospital. This study aimed to investigate the status of the patient safety culture, the frequency of adverse events, and the relationship between them in Qazvin's hospitals in Iran.MethodsThe present study is a descriptive-analytical study conducted in six hospitals in Qazvin, Iran, in 2020. The study population was nurses working in Qazvin hospitals. We collected data via a patient safety culture questionnaire and an adverse event checklist. Three hundred sixty nurses completed questionnaires. Multiple logistic regression was used to investigate the relationship between variables.ResultsThe highest mean of patient safety culture was related to the organizational learning dimension (3.5, SD = .074) and feedback and communication about errors (3.4, SD = 0.82). The participants gave the lowest score to dimensions of exchanges and transfer of information (2.45,=0.86) and management support for patient safety (2.62,Sd = 0.65). Management's support for patient safety, general understanding of patient safety culture, teamwork within organizational units, communication and feedback on errors, staff issues, and information exchange and transfer were significant predictors of adverse events.ConclusionThis study confirms patient safety culture as a predictor of adverse events. Healthcare managers should provide the basis for improving the patient safety culture and reducing adverse events through methods such as encouraging the reporting of adverse events and also holding training courses for nurses.
ISLET: individual-specific reference panel recovery improves cell-type-specific inference
Authors: Feng Hao , Meng Guanqun , Lin Tong , Parikh Hemang , Pan Yue , Li Ziyi , Krischer Jeffrey , Li Qian 
Published: July 2023

AbstractWe propose a statistical framework ISLET to infer individual-specific and cell-type-specific transcriptome reference panels. ISLET models the repeatedly measured bulk gene expression data, to optimize the usage of shared information within each subject. ISLET is the first available method to achieve individual-specific reference estimation in repeated samples. Using simulation studies, we show outstanding performance of ISLET in the reference estimation and downstream cell-type-specific differentially expressed genes testing. We apply ISLET to longitudinal transcriptomes profiled from blood samples in a large observational study of young children and confirm the cell-type-specific gene signatures for pancreatic islet autoantibody. ISLET is available at https://bioconductor.org/packages/ISLET.
In-silico activity prediction and docking studies of some flavonol derivatives as anti-prostate cancer agents based on Monte Carlo optimization
Authors: Tajiani Faezeh , Ahmadi Shahin , Lotfi Shahram , Kumar Parvin , Almasirad Ali 
Published: July 2023

AbstractThe QSAR models are employed to predict the anti-proliferative activity of 81 derivatives of flavonol against prostate cancer using the Monte Carlo algorithm based on the index of ideality of correlation (IIC) criterion. CORAL software is employed to design the QSAR models. The molecular structures of flavonols are demonstrated using the simplified molecular input line entry system (SMILES) notation. The models are developed with the hybrid optimal descriptors i.e. using both SMILES and hydrogen-suppressed molecular graph (HSG). The QSAR model developed for split 3 is selected as a prominent model ($${R}_{Validation}^{2}$$RValidation2= 0.727,$${IIC}_{validation}$$IICvalidation= 0.628,$${Q}_{Validation}^{2}$$QValidation2= 0.642, and$${\overline{r} }_{m}^{2}$$r¯m2=0.615). The model is interpreted mechanistically by identifying the characteristics responsible for the promoter of the increase or decrease. The structural attributes as promoters of increase of pIC50were aliphatic carbon atom connected to double-bound (C…=…, aliphatic oxygen atom connected to aliphatic carbon (O…C…), branching on aromatic ring (c…(…), and aliphatic nitrogen (N…). The pIC50of eight natural flavonols with pIC50more than 4.0, were predicted by the best model. The molecular docking is also performed for natural flavonols on the PC-3 cell line using the protein (PDB: 3RUK).
Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Authors: Fang Qingxiao , Yuan Ziming , Hu Hanqing , Zhang Weiyuan , Wang Guiyu , Wang Xishan 
Published: July 2023

Abstract
Background
Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detection and monitoring the malignant progression in a variety of cancers.

Results
To discover cfDNA methylation markers for the diagnosis of CRC, we first performed a genome-wide analysis between eight CRC and eight polyp tissues using the Infinium HumanMethylationEPIC BeadChip. We identified 7008 DMCs, and after filtering, we validated 39 DMCs by MethylTarget sequencing in 62 CRC and 56 polyp tissues. A panel of four CpGs (cg04486886, cg06712559, cg13539460, and cg27541454) was selected as the methylation marker in tissue by LASSO and random forest models. A diagnosis prediction model was built based on the four CpGs, and the methylation diagnosis score (md-score) can effectively discriminate tissues with CRC from polyp patients (AUROC > 0.9). Finally, the cg27541454 was confirmed hypermethylated in CRC (AUC = 0.85) in the plasma validation cohort.

Conclusions
Our findings suggest that the md-score could robustly detect CRC from polyp tissues, and cg27541454 may be a promising candidate noninvasive biomarker for CRC early diagnosis.