bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of level of the tumor-associated marker SCCA in neoadjuvant superselective intra-arterial chemotherapy in patients with cervical squamous cell carcinoma
Authors: Sergeeva N. S. , Marshutina N. V. , Maltsagova Kh. R. , Karmakova T. A. , Alentov I. I. , Mukhtarulina S. V. , Dezhkina T. I. , Rerberg A. G. , Kaprin A. D. 
Published: May 2023

Background. Evaluation of a tumor-associated marker SCCA (squamous cell carcinoma antigen) level is used in cervical squamous cell carcinoma (CC) to predict the course of the tumor process, monitor the effectiveness of chemo- and chemoradiotherapy, and for preclinical detection of recurrence in follow-up of patients after the completion of primary treatment. However, publications devoted to the study of the possibility of using SCCA level as an additional criterion for the effectiveness of neoadjuvant intra-arterial chemotherapy (IACT) are still rare.Aim. Study of the tumor marker SCCA level in patients with locally advanced squamous CC during neoadjuvant IACT as an additional factor in assessing its effectiveness.Materials and methods. 53 patients with locally advanced squamous CC IB—IVB stages (T1b-3bN0-1M0-1) were included to the study. The mean age of patients was 45.6 years (25-64 years). All patients underwent superselective neoadjuvant IACT with cisplatine (in combination with intravenous administration of docetaxel or paclitaxel). Serum SCCA levels in CC patients were assessed before the first and after the second course of neoadjuvant IACT compared to the clinical effect of treatment after two courses (RECIST 1.1 criteria).Results. SCCA level after 2 courses decreased in all patients with initially increased its level, while the proportion of SCCA-positive cases decreased from 71.7 to 26.4 %. When baseline SCCA values were normal, a complete response was achieved more often than with initially elevated levels (26.7 % vs 15.8 %), while distribution by tumor stages was similar in both subgroups. It has been established that if, after 2 courses of neoadjuvant IACT, SCCA levels exceeds 2.1 ng/ml and/or (for patients with initially increased SCCA value) it decreased by less than 60 % from the baseline, probability to achieve complete response after realization of effect of 2 courses of IACT was extremely small. Strong correlation (R = 0.829) between initial level of SCCA and degree of its decrease after 2 courses of IACT was discovered in the group of patients with complete response after the second course of IACT. It was getting lower in partial response group (R = 0.778) and stabilization group (R = 0.750).Conclusion. Dynamics of SCCA level after 2 courses of IACT in squamous CC patients can be used as additional criterion of the degree of treatment effectiveness.
Features of ovarian steroidogenesis and endometrial hypertrophy during adjuvant therapy with tamoxifen in premenopausal patients with hormone-dependent breast cancer
Authors: Goryainova A. Yu. , Stukan A. I. , Trofimenko A. I. , Meshcheryakov A. A. 
Published: May 2023

Background. Difficulties in the prevention and treatment of endometrial pathology in hormone-positive breast cancer are associated with the lack of an unambiguous understanding of the mechanisms of the effect of tamoxifen on target tissues and the development of possible hyperestrogenism.Aim. To study the effect of ovarian steroidogenesis on the endometrium during adjuvant therapy with tamoxifen in pre-menopausal patients with hormone-dependent breast cancer.Materials and methods. All patients at inclusion in the study had intact menstrual function and received adjuvant therapy with tamoxifen. Group 1 included 42 patients without chemotherapy, group 2 included 41 patients with chemotherapy. Depending on the safety of the menstrual function, each group was divided into 2 subgroups. At the control points (3, 6 and 9 months from the start of tamoxifen therapy) patients underwent transvaginal ultrasound with measurement of endometrial thickness, and also determined the content of follicle-stimulating hormone and estradiol in peripheral blood. When menstruation persisted, blood sampling and measurement of endometrial thickness were performed on days 5-8 of the menstrual cycle.Results. In subgroups 1A and 2C, patients with preserved menstrual function showed a trend towards higher values of estradiol levels and endometrial thickness, compared with subgroups 1B and 2D of patients with amenorrhea. Against this background, the absence of statistically significant intergroup differences in the content of follicle-stimulating hormone in patients receiving tamoxifen with a preserved menstrual cycle (1A and 2C) and amenorrhea (1B and 2D) attracts attention. An intragroup analysis of follicle-stimulating hormone dynamics in patients with amenorrhea without chemotherapy in subgroup 1C shows an increase in its content by 162 %, without statistically significant changes in endometrial thickness and estradiol concentration. The statistically significant increase in endometrial thickness by 25 % and the proportion of patients with increasing endometrial wall thickness in 63.3 % in the 2D subgroup in patients receiving tamoxifen, with amenorrhea and previous chemotherapy treatment are cause for concern.Conclusion. The results of the study indicate a possible additive effect of such factors as intact menstrual function before the start of treatment for hormone-positive breast cancer, chemotherapy, and the development of amenorrhea on the progressive increase in endometrial thickness when using tamoxifen in premenopausal patients.
Melatonin, circadian rhythms and breast cancer
Authors: Eremenko I. I. , Ponomarev V. E. , Vysotskaya I. V. , Polikarpova S. B. , Bogush E. A. , Kirsanov V. Y. , Davydov M. M. 
Published: May 2023

Breast cancer (BC) is the leading cause of morbidity and mortality of malignant neoplasms in women worldwide. In spite of a large number of studies devoted to the etiopathogenesis of this group of malignant tumors, many questions concerning specific mechanisms of their origin and development are still unresearched. Based on numerous studies in recent years, in addition to traditional risk factors (such as hereditary factors, hormonal disorders, environmental factors, etc.), foreign and Russian authors have identified a new risk factor for BC development - the sphere of molecular disorders affecting circadian rhythms and circadian genes, as well as metabolic and regulatory intracellular pathways regulated by them. It has been shown that the balance between oncogenes and suppressor genes and processes such as neoangiogenesis, metastasis and antitumor immune response depend on the functioning of the circadian rhythm system. One of the key metabolites in the circadian rhythm regulation system is melatonin, which physiological effects extend not only to the central nervous system, but also to peripheral tissue cells. The study of the relationship between circadian rhythm disturbances, melatonin secretion and malignant tumors is one of the important tasks of modern oncology. In the present review the following aspects of this problem are considered in detail: relationships between circadian rhythms, melatonin and BC; molecular mechanisms of melatonin antitumor action in BC; therapeutic potential of melatonin in prevention and treatment of malignant breast tumors as a direct antitumor agent, a component of accompanying treatment, and as a radiosensitizer and radioprotector for radiotherapy. The purpose of this review is to investigate the problem of the relationship between the circadian rhythm system, melatonin and molecular mechanisms of development and progression of breast malignancies, as well as the therapeutic potential of melatonin in their prevention and treatment. The review is based on the study of relevant and reliable scientific articles, reviews, meta-analyses, systematic reviews, and clinical trials published in Scopus, PubMed, Web of Science and in peer-reviewed Russian journals mainly during the last 5 years.
Загальна модель високопродуктивних обчислень
Authors: Гамаюн В.П. 
Published: May 2023

Запропонована модель для дослідження організації високопродуктивних обчислень. Модель орієнтована на архітектури з масовим паралелізмом, головню є організація багатооперандної обробки. Процесорні елементи забезпечують небінарну обробку даних за один операційний цикл. Модель забезпечує також квазиграфічну обробку, що реалізує обчислення результату як розпізнавання графічного блоку – матрицю ущільненого коду одиниць. Цей метод виключає традиційне додавання, а є альтернативним відомим методам та розширює теоретичні та практичні методи загальної моделі.
Макрооператорні напрямки перетворення алгоритмів дозволяють змінити послідовність виконання частини програми або повністю програму. Кількість ярусів програми зменшується, тобто продуктивність збільшується, а конвеєризація також збільшує продуктивність.
Результат роботи моделі показує рівні продуктивності які можливо досягнути при застосуванні архітектури з масовим паралелізмом та багатооперандною обробкою. Реалізація моделі залишається відкритою, бо дозволяю приєднувати нові методи обробки та нові архітектури для дослідження.
Захист мереж транспортних засобів від несанкціонованого доступу шляхом ізоляції протоколів обміну
Authors: Дрововозов В.І. , Водоп’янов С.В. , Журавель С.В. 
Published: May 2023

Статтю присвячено дослідженню методів захисту безпроводових інформаційно-телекомунікаційних систем транспорту. За результатами аналізу методів організації та забезпечення якості обслуговування в перспективних інформаційно-комунікаційних та комп’ютерних мережах критичного застосування виявлено, що основним проблемами для мереж є різнорідність мережного трафіку та перевантаження, які погіршують показники QоS. Запобігання перевантаженню реалізується шляхом побудови багаторівневої ієрархічної структури, але методи узгодження протоколів взаємодії автономних мережних сегментів потребують вдосконалення. Специфікою безпроводових мереж є розповсюдження сигналів через вільне середовище, тобто принципово відкритий доступ до сигналів як до носіїв інформації, яка передається від одного абонента іншому. Тому, окрім загальних проблем управління інформаційно-телекомунікаційними мережами, у безпроводових мережах досить гостро стоять проблеми захисту від несанкціонованих втручань та зовнішніх завад самого різного походження. Для захисту мережних сегментів із закритим доступом від несанкціонованого проникнення (хакерської атаки на мережу, перехоплення управління транспортним засобом) розроблено методи ізоляції протоколів закритого доступу від протоколів обмеженого та відкритого (загального) доступу. Статистичних показників повідомлень, зокрема, кількість вхідних та вихідних IP, TCP, UDP пакетів на інтервалі спостереження, час отримання та відправлення пакетів та ін., є параметрично несумісними, а відповідні коефіцієнти взаємної кореляції є величинами другого порядку малості; сукупності сигнатурних показників повідомлень у закритому доступі, у обмеженому доступі, у відкритому доступі та сигнатури атак представляють собою компоненти векторів, майже ортогональних одне одному, а їх скалярні добутки – величини другого порядку малості; за результатами статистичного та сигнатурного аналізу фільтруються спроби як випадкового, так і навмисного несанкціонованого втручання до сегментів з закритим та обмеженим доступом.
Формалізація процесу випробувань дослідних зразків льотно-технічного обмундирування
Authors: Хуторна М.Е. , Пантєлєєва Н.М. , Чередніков О.М. , Шевченко Д.Т. , Хмель Е.В. 
Published: May 2023

У роботі розглядається підхід щодо формалізації процесу випробувань для побудови структури інформаційної моделі випробувань дослідних зразків льотно-технічного обмундирування (ЛТО), призначеного для захисту льотно-технічного складу авіації Збройних Сил України від впливу несприятливих факторів навколишнього середовища та створення із захисним спорядженням та іншими системами забезпечення життєдіяльності, необхідних умов для виконання особовим складом своїх функціональних обов’язків.
Авторами обговорюється важливість виконання випробувань для забезпечення безпеки льотного персоналу та підвищення ефективності виконання завдань авіаційних підрозділів наводяться етапи процесу випробувань, починаючи від планування до аналізу результатів. У статті також звертається увага на важливість стандартизації процесу випробувань та використання документації, що визначається вимогами ДСТУ EN ISO/IEC. Отже, стаття зосереджується на розробці нової формалізованої методики оцінки показників якості льотно-технічного обмундирування, яка забезпечує ефективність випробувань та більш точну та об'єктивну оцінку дослідних зразків.
Marxism as a Psychoconceptual Weapon
Authors: Chernikov M.V. 
Published: May 2023

In this article, a hypothesis is put forward according to which Marxism owes its popularity and influence in the European revolutionary labor movement (at least in the late XIX – early XX centuries) not so much to its value as a scientific theory as to other circumstances. It is discussed that the Marxist socio-political theory, not being true from a scientific point of view, is a conceptual formation successfully camouflaged under a true scientific theory, which being indoctrinated into mass public consciousness could act as a kind of “psychoconceptual weapon” capable of directing mass collective action towards achieving the goals that the managers of this “psychoconceptual weapon” set for themselves.
Schoolboy&#x27;s Perception of the News About the Arrested Uncle (According to His Own Memories)
Authors: Mininkov N.A. 
Published: May 2023

Modern humanitarian research suggests the need for active heuristic work aimed at searching for personal memories. It pays special attention to the subjective perception of historical events, phenomena and processes. In particular, this applies to the memories of children whose consciousness was beginning to form, and who perceived historical events in their own way. The article contains a fragment of the author&#x27;s memoirs of the news about his uncle, the famous Soviet and Russian historian N.N. Pokrovsky, who served 6 years in the case of the Krasnopevtsev-Rendel group.
Ideology in Russia of the Time of Postmodernity and Special Operation
Authors: Rubtsov A.I. 
Published: May 2023

Meanings in the rhetoric of “past and present” are determined by the historical size of events and intervals. If modernity was a time of ideologies, then Russia turned out to be the chosen place for the implementation of total projects, and the triumph of Marxism as a state worldview with absolute criticism of the ideological. Like the constitution of politics by Carl Schmitt through the binary opposition “friend – enemy”, ideology is constituted in the opposition “faith – knowledge”, in the spectrum between “almost religion” and ”near philosophy”. The task of philosophy is to reveal the non-obviousness of the supposedly obvious; the mission of ideology is the mass production of “obviousness”. Overcoming narrowly political reductionism reveals ideology in its extreme expansion and thus distinguishes difference between systems of ideas and systems of institutions, along with shadow, latent, diffuse, penetrating and other formats of ideology.
Post-exposure prophylaxis of COVID-19: results of double-blind, placebo-controlled, multicenter clinical study evaluation of efficacy and safety of double-stranded sodium salt RNA drug
Authors: Balykova L. A. , Radaeva O. A. , Zaslavskaya K. Ya. , Taganov A. V. , Bely P. A. , Zakharov K. A. , Popova V. V. , Chudinovskikh T. I. , Teplykh S. V. , Balaban I. V. , Kozlov R. S. , Kirichenko N. V. , Simakina E. N. , Koryanova K. N. , Pushkar D. Yu. 
Published: May 2023

The aim of the study was to evaluate the efficacy and safety of an RNA double-stranded sodium salt drug, a lyophilisate for a solution preparation for an intramuscular and subcutaneous administration, as a means of post-exposure COVID-19 prophylaxis in comparison with placebo.Material and methods. A double-blind, placebo-controlled, multicenter, randomized phase III clinical trial was conducted to evaluate the efficacy and safety of a double-stranded sodium salt RNA drug (RADAMIN®VIRO), a lyophilisate for preparing a solution for intramuscular and subcutaneous administration as a means of post-exposure prophylaxis of COVID-19. The study was conducted in 10 research centers in the Russian Federation from May 31, 2022 to January 17, 2023. The study included men and women aged ≥18 years who cohabitate with a person with a documented COVID-19 diagnosis and do not have symptoms characteristic of COVID-19. At the randomization stage, the subjects were assigned to one of two groups: group 1 (n=400) received a study drug RADAMIN®VIRO 5 mg (1 vial) intramuscularly once a day; group 2 (n=400) received placebo 1 vial intramuscularly once a day. The total duration of the study for each subject was no more than 30 days.Results. By day 10-11, in the double-stranded sodium salt RNA preparation group, the proportion of the subjects with confirmed COVID-19 and at least 1 symptom characteristic of COVID-19 was 5.76% (23/399), and in the placebo group – 11. 03% (44/399). The difference in proportions between the study drug and placebo groups was 0.0526 (5.26%), the 95% confidence interval (CI) for the difference in proportions between the groups was -95% CI [0.0123;0.0937]). More than 94% of single-dose subjects did not become infected with COVID-19 with any symptoms during the 11 days of the follow-up. As a result of a comparative analysis, it was shown that the infection frequency in the study drug group was statistically significantly (almost twice) less than in the comparison group, which indicates a high efficiency and expediency of using the double-stranded sodium salt RNA preparation as a means of the post-exposure COVID-19 prophylaxis.Conclusion. Thus, regardless of the vaccination availability, the effectiveness and feasibility of using the study double-stranded sodium salt RNA preparation as a means of the post-exposure COVID-19 prophylaxis was demonstrated not only in medical institutions (outpatient clinics and hospitals), but also in caregivers and/or the persons in contact with COVID-19 patients. The situation was the same in the organizations and enterprises in case of evolution of a mass infection threat and the availability of appropriate medical personnels.
THE DEVELOPMENT OF ETHNOSCIENCE BASED HIGH SCHOOL PHYSICS ENRICHMENT BOOK IN THE TRADITIONAL PROCESSING OF NUR KERINCI COFFEE
Authors: Jufrida Jufrida , Basuki Fibrika Rahmat , Kurniawan Wawan , Milyani Vetty 
Published: May 2023

This research is development research that aims to develop an ethnoscience-based high school physics enrichment book on the traditional processing of Nur Kerinci coffee and to find out the students’ perceptions about the enrichment book. The subjects of this study were material experts, media experts, and class XII MIPA 1 students of SMAN 11 Kota Jambi, totaling 24 students. The instruments used in this study were observation sheets, interview sheets, expert validation sheets, student perception questionnaires, and documentation. The resulting data are in the form of qualitative and quantitative data. Qualitative data were analyzed descriptively and quantitative data were analyzed using descriptive statistics. Local wisdom in the form of traditional processing of Nur Kerinci coffee is used as a context for the problem to explore scientific concepts, especially physics concepts. The results of the material expert validation obtained an average score of 93.33% with the "very good" category and the media expert at 93.33% with the "very good" category. Meanwhile, the results of the student perception trial obtained an average score percentage of 89.53% in the "very good" category.
A Technical Approach to Anesthesia in the Case of Tonsillectomy
Authors: Cahyo Febrian Dwi , Sutanto Bambang , Mahmuda Iin Novita Nurhidayati 
Published: May 2023

<div class="WordSection1"><p><strong>Background: </strong>Tonsillectomy is the most common surgical procedure performed by an ENT doctor (Throat Nose Ear) in children. This surgery can cause pain, bleeding and swelling in the injured throat. Patient may complain of pain, difficulty swallowing, eating, drinking disorders, nausea and vomiting and fall into a dehydrated state. This can reduce patient satisfaction.</p><p><strong>Discussion:</strong> Postoperative pain management of tonsillectomy is a concern both by the ENT doctor and by the anesthesiologist. The high incidence of post-tonsillectomy pain or anxiety increases the risk of secondary post-tonsillectomy bleeding. It is necessary to know the mechanism of post operative pain and the negative impact of pain.</p><p><strong>Conclusion:</strong> Doctors should give attention to reduce postoperative pain and choose a rational analgesic to overcome post operative tonsillectomy pain.</p></div>
Comparison Between Norepinephrine-Epinephrine and Norepinephrine-Vasopressin Effectiveness in Reducing Mortality in Septic Shock: A Systematic Review
Authors: Tan Kenneth , Benedictus Benedictus , Purnomo Christopher William 
Published: May 2023

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p> </p><p><strong>Background: </strong>Sepsis is a state of organ dysfunction caused by the immune system’s abnormal response to an infection. Septic shock is sepsis complicated by circulatory and metabolic abnormalities, oftentimes resulting in death. Prompt identification and treatment of septic shock is crucial for the survival of patients. The latest international guideline recommends the administration of norepinephrine as the first line vasopressor, with the addition of epinephrine or vasopressin as an aid in achieving the target MAP (Mean Arterial Pressure).</p><p><strong>Methods: </strong>This study is a systematic review of literatures from the databases Pubmed PMC, Science Direct, and Proquest. Systematic reviews on septic shock, norepinephrine, and epinephrine or vasopressin were among the inclusion criterias. This resulted in a total of five systematic reviews to be included in the qualitative synthesis.</p><p><strong>Results: </strong>The five included studies were not in sync as to which vasopressor is best used for the treatment of septic shock patients. One of which did not compare the two combinations within the same category, two of which favored the use of norepinephrine-epinephrine, and the other two favored the use of norepinephrine-vasopressin for the treatment of septic shock patients.</p><p><strong>Conclusion: </strong>The existing evidence were insufficient to give a conclusion of the best combination of vasopressors for septic shock patients. More research, specifically randomized controlled trials, needs to be conducted on this topic with well defined administration of combinations of vasopressors as an advancement of this systematic review. The writers also recommend the delay of anymore systematic reviews until the former recommendation has been met.</p></div></div></div>
RE-BRANDING ACEH: KONTESTASI RUANG PUBLIK ISLAM, OTONOMI KHUSUS DAN STRATEGI BARU
Authors: Husna Fathayatul 
Published: May 2023

Aceh is well known as a region that applies Islamic law as a whole. Times have brought about the intake of social changes which also have an influence on the social order of religion in Aceh. researcher examined through two main conditions, before and after special autonomy legitimation. This theme should to be examined because researcher argue there is Islamic content development in Aceh public space. This paper examines the Islamic public sphere in Aceh as an area with Islamic legitimacy. the author wants to see how the discourse on Islamic public space after the development of technology at the same time and after the conflict. This type of research is descriptive qualitative. The author uses a virtual ethnography method. The result that the authors get is that the Islamic public sphere in Aceh has changed between before the special autonomy was passed and after the special autonomy. Obviously, the development of the Islamic public space in Aceh has been fed by technological developments after the 2004 tsunami.