bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Artemisia Argyi (AA) Therapy in Alzheimer's Disease (AD) Using Network Pharmacology and Molecular Docking
Authors: Wang Yin , Huang Ruixue 
Published: January 2023

AbstractThis study aims to investigate the molecular mechanism of Artemisia argyi (AA) in the treatment of cognitive impairment of Alzheimer's disease (AD) and the docking activity of AA on potential therapeutic targets using network pharmacology and molecular docking techniques. Bioinformatic analysis showed that neuroactive ligand‐receptor interaction, the pathway of cancer, calcium signaling, neurodegeneration‐multiple disease, and chemical carcinogenesis‐receptor activation might be the related signal pathway in AA‐AD. Moreover, the binding energy of AA active compounds to potential targets are ≦−4.16 kJ mol−1 with 10 patterns ≦−10 kJ mol−1. The results of molecular docking showed that there would be a stable binding ability between the active components of AA and potential target genes. Among them, 24‐methylenecyloartanone, beta‐sitosterol, and Stigmasterol are active components with potential oral bioavailability (OB), drug‐likeness (DL), and blood‐brain‐barrier(BBB) are screened out with the stable binding ability to target genes, which may be potential components of AA treatment for AD. This study laid an important foundation for further study of the molecular mechanism of AA treatment for AD.
Crystallization‐Induced Enhanced Electrochemiluminescence from a New Tris(bipyridine)ruthenium(II) Derivative
Authors: Han Tingting , Cao Yue , Wang Jia , Jiao Jianmin , Song You , Wang Leyong , Ma Cheng , Chen Hong‐Yuan , Zhu Jun‐Jie 
Published: January 2023

AbstractClassic tris(bipyridine)ruthenium(II) complex (Ru‐bpy) with high electrochemiluminescence (ECL) efficiency still suffers from a serious aggregation‐caused quenching (ACQ) problem, which greatly weakens its ECL efficiency to restrict further applications in solid‐state ECL imaging and light‐emitting devices. Herein, the crystallization‐induced enhanced ECL (CIE‐ECL) of tris(bipyridine)ruthenium(II) derivatives (Ru‐TPE) are reported by decorating Ru‐bpy with inherent aggregation‐induced emission active tetraphenylethene (TPE), which effectively eliminates the detrimentalπ–πstacking interactions and thus helps Ru‐bpy surmount notorious ACQ effect in the aqueous phase. The Ru‐TPE shows negligible ECL emission in solution but produces a strong ECL emission upon crystallization. Surprisingly, the ECL efficiency of Ru‐TPE crystals is 20 and 3 times higher than that of its solution and Ru‐bpy crystals, respectively. Experimental and structural analysis reveals that such a CIE‐ECL effect originates from the restricted intramolecular rotation and ordered molecular packing. Moreover, the high‐resolution ECL imaging of a single Ru‐TPE crystal is successfully demonstrated. This work provides a new design strategy for achieving high efficiency in solid‐state ECL imaging and devices.
Flexible Substrate‐Structured Sb2S3 Solar Cells with Back Interface Selenization
Authors: Deng Hui , Cheng Yingshun , Chen Zekun , Lin Xiao , Wu Jionghua , Zheng Qiao , Zhang Caixia , Cheng Shuying 
Published: January 2023

AbstractAntimony sulfide (Sb2S3) with a 1D molecular structure has strong bending characteristics, showing great application potential in flexible devices. Herein, the flexible substrate‐structured Sb2S3 solar cells is developed and improve device performances by the back interface selenization. The high‐quality Sb2S3 film with an optimal thickness of 1.8 µm, ensuring efficient spectra utilization, is deposited on flexible Mo foils by the rapid thermal evaporation technique. To solve the issues of back interfacial recombination and charge transport, the 20 nm MoSe2 layer between Sb2S3 film and Mo foil is fabricated by substrate selenization in the tube furnace. Further investigations indicate that the MoSe2 layer improves the interfacial energy band alignments and induces the [hk1] orientation of Sb2S3 film, thereby passivating defects and enhancing the carrier transport capacity. The flexible solar cell in the structure of Mo foil/MoSe2/Sb2S3/CdS/ITO/Ag, exhibiting good flexibility to stand thousands of bending, achieves an efficiency of 3.75%, which is the highest for Sb2S3 devices in substrate configuration. The presented flexible structure and back interfacial selenization study will provide new prospects for inorganic Sb2S3 thin film solar cells.
Graphene Spin Valves for Spin Logic Devices
Authors: Ghising Pramod , Biswas Chandan , Lee Young Hee 
Published: January 2023

AbstractAn alternative to charge‐based electronics identifies the spin degree of freedom for information communication and processing. The long spin‐diffusion length in graphene at room temperature demonstrates its ability for highly scalable spintronics. The development of the graphene spin valve (SV) has inspired spin devices in graphene including spin field‐effect transistors and spin majority logic gates. A comprehensive picture of spin transport in graphene SVs is required for further development of spin logic. This review examines the advances in graphene SVs and their role in the development of spin logic devices. Different transport and scattering mechanisms in charge and spin are discussed. Furthermore, the on/off switching energy between graphene SVs and charge‐based FETs is compared to highlight their prospects for low‐power devices. The challenges and perspectives that need to be addressed for the future development of spin logic devices are then outlined.
Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications
Authors: Zhang Lu , Wang Huan , Qu Xiaogang 
Published: January 2023

AbstractNanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue of their advantages of high catalytic stability, ease of functionalization, and low cost. However, due to the lack of predictable descriptors, most of the nanozymes reported in the past have been obtained mainly through trial‐and‐error strategies, and the catalytic efficacy, substrate specificity, as well as practical application effect under physiological conditions, are far inferior to that of natural enzymes. To optimize the catalytic efficacies and functions of nanozymes in biomedical settings, recent studies have introduced biosystem‐inspired strategies into nanozyme design. In this review, recent advances in the engineering of biosystem‐inspired nanozymes by leveraging the refined catalytic structure of natural enzymes, simulating the behavior changes of natural enzymes in the catalytic process, and mimicking the specific biological processes or living organisms, are introduced. Furthermore, the currently involved biomedical applications of biosystem‐inspired nanozymes are summarized. More importantly, the current opportunities and challenges of the design and application of biosystem‐inspired nanozymes are discussed. It is hoped that the studies of nanozymes based on bioinspired strategies will be beneficial for constructing the new generation of nanozymes and broadening their biomedical applications.
Spin Preserved Exciton Funneling through a Polaronic Intermediate State in Layered Perovskite Single Crystals
Authors: Zhang Yiwei , Zhang Baohuan , Wang Jiawei , Fu Yulan , Han Yu , Guo Jinxin , Zhang Xinping 
Published: January 2023

AbstractThe spintronic device is another application of perovskite beyond solar cells, light emitting diodes, and photodetectors. Spin relaxation with a lifetime of several ps has been observed in both 3D and 2D perovskite. In this study, Ruddlesden–Popper (RP) perovskite single crystals with mixed n and n + 1 phase are synthesized. It is found that the spin‐polarized exciton can funnel from n phase to n + 1 phase with spin information retained effectively. Interestingly, the spin lifetime of the funneled exciton in n + 1 phase is much longer than that in the pristine n phase. This is attributed to the fact that the funneling is realized through a polaronic intermediate state, in which the spin relaxation is much slower. The polaronic intermediate states originate from the interaction between photogenerated excitons and the lattice distortion. The formation of the polaronic states can reduce overlap of electron–hole wave function and modified lattice symmetry; these two changes contribute to retain the exciton spin information in such polaronic states. The findings deepen the understanding of spin‐polarized exciton transportation and relaxation dynamics and provide a potentially novel approach to enhance the spin relaxation lifetime of perovskite single crystals.
An Unexpected Boron Rearrangement Leads to a Fluorogenic and Colorimetric BODIPY Probe
Authors: Merkes Jean Michel , Raabe Gerhard , Kiessling Fabian , Rueping Magnus , Banala Srinivas 
Published: January 2023

AbstractThe isolation and characterization of a kinetically stable oxadiazaborinine (ODB) dye are described, which undergoes an unexpected thermal boron rearrangement with a color change and increase in fluorescence. This controllable reaction allows for the use as a practical time‐temperature indicator probe with the advantages of photostability, non‐reversibility, and environmental friendliness.
Water‐Dependent Upcycling of Eco‐Friendly Multifunctional Nanocompartmentalized Films
Authors: Caetano Izabella W. I. A. , Ferreira Filipe V. , dos Santos Danilo M. , Pinheiro Ivanei F. , Lona Liliane M. F. 
Published: January 2023

AbstractNanocompartmentalized films are promising materials for different applications, including biomedical, food, and agricultural fields. Herein, a new concept to prepare such multifunctional films is reported. Aqueous dispersion of nanoparticles based on Ecovio loaded with an active compound (Neem oil as concept proof) is first synthesized by single emulsion–solvent evaporation technique using poly(vinyl alcohol) (PVA) as a surfactant. Then, this dispersion is used to prepare films by casting. The feasibility of upcycling (i.e., deconstruction and reassembly of the films) is obtained through a water‐dependent dynamic phenomenon, where the PVA acts as polymer matrix or surfactant depending on the hydration of the surrounding medium (dry or wet conditions). Nanocompartmentalized films demonstrate improved mechanical performance and reduced transmittance in UVA and UVB spectra, while the nanoparticles (wet condition) show superior stability (more than 9 months). The proposed method allows preparing films with high compartmentalization efficiency that can be used, for instance, as insect‐repellent packaging. Just by adding the films in water, the aqueous dispersion of nanoparticles can be used for controlled release of pesticides, leading to high added value material that fits the circular economy.
Delineating the phenotype of RNU4ATAC‐related spliceosomopathy
Authors: Tabib Amanda , Richmond Christopher M. , McGaughran Julie 
Published: January 2023

AbstractBiallelic pathogenic variants in RNU4ATAC cause microcephalic osteodysplastic primordial dwarfism type I (MOPD1), Roifman syndrome (RS) and Lowry–Wood syndrome (LWS). These conditions demonstrate significant phenotypic heterogeneity yet have overlapping features. Although historically described as discrete conditions they appear to represent a phenotypic spectrum with clinical features not always aligning with diagnostic categories. Clinical variability and ambiguity in diagnostic criteria exist among each disorder. Here we report an individual with a novel genotype and phenotype spanning all three disorders, expanding the phenotypic spectrum of RNU4ATAC‐related spliceosomeopathies.
Electron Spin Catalysis with Graphene Belts
Authors: Tian Yulan , Cao Huaqiang , Yang Haijun , Yao Wenqing , Wang Jiaou , Qiao Zirui , Cheetham Anthony K. 
Published: January 2023

AbstractHere, we report kinetic studies using electron spin resonance spectroscopy on spin catalysis reactions caused by using graphene belts which were synthesized by a radical coupling method. The results show that σ‐type free radical species provide the dominant sites for catalytic activity through the spin‐spin interaction, although there are some other influencing factors. The spin catalysis mechanism can be applied both in the oxygen reduction reaction (ORR) and in organic synthesis. The graphene belt spin catalyst shows excellent performance with a high ORR half‐wave potential of 0.81 V and long‐term stability with almost no loss of activity after 50 000 cycles in alkaline media. It also shows excellent performance in a benzylamine coupling with molecular oxygen to generate the corresponding imine at an average conversion of ≈97.7 % and an average yield of ≈97.9 %. This work opens up a new research direction for understanding aerobic processes in the field of spin catalysis.
The Rise of Trichlorides Enabling an Improved Chlorine Technology
Authors: Kleoff Merlin , Voßnacker Patrick , Riedel Sebastian 
Published: January 2023

AbstractChlorine plays a central role for the industrial production of numerous materials with global relevance. More recently, polychlorides have been evolved from an area of academic interest to a research topic with enormous industrial potential. In this minireview, the value of trichlorides for chlorine storage and chlorination reactions are outlined. Particularly, the inexpensive ionic liquid [NEt3Me][Cl3] shows a similar and sometimes even advantageous reactivity compared to chlorine gas, while offering a superior safety profile. Used as a chlorine storage, [NEt3Me][Cl3] could help to overcome the current limitations of storing and transporting chlorine in larger quantities. Thus, trichlorides could become a key technique for the flexibilization of the chlorine production enabling an exploitation of renewable, yet fluctuating, electrical energy. As the loaded storage, [NEt3Me][Cl3], is a proven chlorination reagent, it could directly be employed for downstream processes, paving the path to a more practical and safer chlorine industry.
Achieving Near‐unity Photoluminescence Quantum Yields in Organic‐Inorganic Hybrid Antimony (III) Chlorides with the [SbCl5] Geometry
Authors: Sun Chen , Deng Zeyu , Li Zhiyuan , Chen Zhongwei , Zhang Xuanyu , Chen Jian , Lu Haipeng , Canepa Pieremanuele , Chen Rui , Mao Lingling 
Published: January 2023

AbstractHybrid organic–inorganic antimony halides have attracted increasing attention due to the non‐toxicity, stability, and high photoluminescence quantum yield (PLQY). To shed light on the structural factors that contribute to the high PLQY, five pairs of antimony halides with general formulaA2SbCl5andA2Sb2Cl8are synthesized via two distinct methods and characterized. TheA2SbCl5type adopts square pyramidal [SbCl5] geometry with near‐unity PLQY, while theA2Sb2Cl8adopts seesaw dimmer [Sb2Cl8] geometry with PLQY≈0 %. Through combined data analysis with the literature, we have found thatA2SbCl5series with square pyramidal geometry generally has much longer Sb⋅⋅⋅Sb distances, leading to more expressed lone pairs of SbIII. Additional factors including Sb−Cl distance and stability of antimony chlorides may also affect PLQY. Our targeted synthesis and correlated insights provide efficient tools to precisely form highly emissive materials for optoelectronic applications.
Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications?
Authors: Vandergrift Gregory W. , Lukowski Jessica K. , Taylor Michael J. , Zemaitis Kevin J. , Alexandrov Theodore , Eder Josie G. , Olson Heather M. , Kyle Jennifer E. , Anderton Christopher 
Published: January 2023

AbstractMass spectrometry imaging (MSI) is an invaluable tool for the spatial visualization of molecules in vivo. However, the question of whether observed annotations are endogenous or artificial (i. e., from in‐source fragmentation) is critical and has been largely unexplored in multimodal MSI. In matrix‐assisted laser desorption/ionization (MALDI)‐MSI datasets from researchers worldwide, PAs were found to represent up to 18 % of annotations in rat brain. Rat brain was additionally imaged here using nanospray desorption electrospray ionization (nano‐DESI), a softer ionization strategy. No PAs observed with MALDI were present in the nano‐DESI dataset. Further investigation strongly indicated lipid fragmentation to PAs for MALDI‐MSI, but not with nano‐DESI‐MSI. We finally extend this observation to the MALDI‐MSI analyses of human tissues, showing that PA annotations comprised up to 16 % of annotations. Therefore, this study shows that MSI annotations should be carefully interrogated, as in‐source fragmentation or modification of lipids may contribute substantially to false annotations and incorrect biological interpretations.
Solid polymer electrolyte membrane based on cationic polynorbornenes with pending imidazolium functional groups for all‐solid‐state lithium‐ion batteries
Authors: Qin Zengwei , He Xiaohui , Xu Jiang , Deng Jiahao , Zang Xiujing , Yang Guoxiao , Lu Yao , Zou Shaoyu , Huang Liang , Chen Defu 
Published: January 2023

AbstractSolid polymer electrolytes (SPEs) have received extensive attention in the realm of lithium‐ion batteries due to their safety performance, higher specific capacity and structural designability. In recent years, poly ionic liquids (PILs) have been attracting the attention of many researchers because of their high ionic conductivity, wide electrochemical stability window, high thermal stability and less‐flammability in comparison with common liquid electrolytes. We selected imidazole cations as functional groups to be attached to the side chain of the polymer to prepare bis‐imidazole functionalized benzo‐norbornadiene monomer, which copolymerized with epoxy‐functionalized norbornene monomer and norbornene (NB) monomer to obtain triblock copolymer. The prepared triblock copolymer was blended with lithium salt (LiTFSI) to obtain a solid polymer electrolyte membrane (SPEM). SPEM achieved an excellent ionic conductivity of 3.1 × 10−5 S cm−1 at 30°C, exhibited an electrochemical stability window of up to 4.3 V versus Li/Li+ (25°C) and thermal stability up to 275°C under protective (N2) atmosphere. The NCM811/SPEM/Li batteries have exhibited a first discharging capacity of 149.1 mAh g−1 at 0.1 C‐rate and the discharge capacity kept 141.6 mAh g−1 at 0.2 C‐rate after 50 charge and discharge cycles at 30°C.
Water diffusion kinetics study at different hydrothermal bath temperatures and subsequent durability studies of CNT embedded fibrous polymeric composites: Roles of CNT content, functionalization and in‐situ testing temperature
Authors: Fulmali Abhinav Omprakash , Ramamoorthy Sunil Kumar , Prusty Rajesh Kumar 
Published: January 2023

AbstractAlthough structural polymers like epoxy are extensively used in marine applications over metallic structures, environmental water tends to ingress into this polymer which may affect its long‐term durability. The extent of degradation caused by the absorbed water on polymeric composite's mechanical properties depends on the water diffusion mechanism, environmental temperature and subsequent reversible and irreversible chemical restructuring of the polymer. In this study, hydrothermal conditioning behavior of glass fiber reinforced epoxy (GE) composites with varying (0.1, 0.3, and 0.5) wt.% of pristine and functionalized carbon nanotubes (CNTs and FCNTs) was studied at 15°C (Low‐Temperature Hydrothermal Conditioning (LTHC)) and 50°C (Elevated‐Temperature Hydrothermal Conditioning (ETHC)) water baths. The changes in chemical bonding characteristics and glass transition temperature of GE composite due to above mentioned factors have been studied by Fourier transformed infrared spectroscopy and differential scanning calorimetry. The gravimetric analysis was employed to monitor the water uptake kinetics of the composites and flexural strength of conditioned composites after 50 days of conditioning and saturation was study to understand the effect of water sorption. Experimental results revealed that, FCNTs greatly hinders the water absorption through the interfaces at LTHC, as the equilibrium water content of 0.1FCNT‐GE composite was ~9.5% and ~3.0% and Diffusion coefficient was ~60.0% and ~15.5% lower than the GE and 0.1CNT‐GE composites, respectively at LTHC. At LTHC, the water saturated 0.1FCNT‐GE composites exhibited superior flexural strength than GE and 0.1CNT‐GE composites. At ETHC, generation of hygroscopic stresses and unfavorable stresses at the weak CNT/polymer interface adversely affected the 0.1CNT‐GE composites water resistance compared to 0.1FCNT‐GE composites with stronger FCNT/polymer interface. The extent of recovery in the flexural strength was evaluated by complete desorption of water‐saturated specimens. Finally, a fractography study was conducted to understand the variation in the well‐being of the glass fiber/polymer and nanotube/polymer interface due to mentioned varying factors.
Association between the social network of medical students and their academic performance on the anatomy written examination
Authors: Nawa Nobutoshi , Numasawa Mitsuyuki , Yamaguchi Kumiko , Morita Ayako , Fujiwara Takeo , Akita Keiichi 
Published: January 2023

AbstractAlthough medical students learn human anatomy within a social network of friends/classmates, limited research has examined how social network structure is related to student's performance in human anatomy examinations. This study aimed to examine the association between centrality (i.e., the degree to which a student is connected to other students in class) before the start of the anatomy laboratory and changes in centrality owing to the start of the laboratory and failing the written examination taken on the last day of the course. Data included all 211 medical students at Tokyo Medical and Dental University who took anatomy classes in 2018 and 2019. The in‐class social network before the laboratory was defined as “connected” if the student had more than one connection to the same individual in terms of the type of club activity, high school, and affiliation with an extracurricular program. The laboratory group adds the connection to the prelaboratory network, resulting in a postlaboratory network. Logistic regression models were used to estimate the association of degree and eigenvector centrality and changes in centrality after the laboratory with failing the written examination. Of the 211 students, 38 failed the examination. A one standard deviation increase in eigenvector centrality before the laboratory was significantly associated with a 44% decrease in odds of failing the examination (OR: 0.56, 95% CI: 0.34, 0.92). Changes in centrality measures were not associated with the performance of students in the examination. Higher in‐class network centrality was associated with lower odds of failing the written examination.