bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catastrophic outcomes of thrombus ‘bumper’ ball in neglected severe rheumatic mitral stenosis: report of three cases
Authors: Agoumy Zineb , Bachri Houda , Mhadi Samah E L , Chraibi Hamza , Fehri Zineb F , Bakamel Lamyaa , El Assili Hala , Berrag Kaoutar , Es-sebany Sanae , Leghlimi Hasna , Lachhab Fadwa , Tribak Mohamed , Bensouda Adil , Chaib Ali , Bendagha Nesma , Soufiani Aida , Moughil Said 
Published: May 2023

Abstract
Patients with rheumatic mitral stenosis (MS) often present complications such as atrial fibrillation and thrombus formation with significant morbi-mortality. Rarely, a free-floating ‘ball thrombus’ is found with possible catastrophic outcomes. We describe three cases of documented left atrial ‘ping-pong’ shaped ‘thrombus ball’ within MS: a 51 year old presented with acute heart failure with a fatal outcome due to the huge round thrombus closing the tight mitral valve, a 67-year-old and a 68-year-old male who were both urgently rushed to the operating room after accidental finding. The surgery was successful and consisted on mitral valve repair and thrombectomy. Our aim is to show that gigantic unattached thrombus ball within neglected rheumatism MS is a rare life-threatening entity, thus highlighting the importance of early diagnosis of such conditions present in endemic countries. A prompt surgery should be considered to avoid an eventual embolization and sudden death.
The design of synthetic gene circuits in plants: new components, old challenges
Authors: Vazquez-Vilar Marta , Selma Sara , Orzaez Diego 
Published: May 2023

AbstractThe fascination produced by the possibility of engineering plants with augmented capabilities has accompanied plant biotechnology since its origins. This prospect has become even more relevant in present times under the pressure imposed by climate change and population growth. Today’s plant biotechnologists approach this challenge with the tools of synthetic biology, which facilitate the assembly of synthetic gene circuits (SGCs) from their modular components. Transcriptional SGCs take environmental or endogenous inputs and operate them using transcriptional signals in ways that do not necessarily occur in nature, generating new physiological outputs. Many genetic components have been developed over the years that can be employed in the design and construction of plant SGCs. This review aims to provide an updated view of the components available, proposing a general scheme that facilitates the classification of circuit components in sensor, processor, and actuator modules. Following this analogy, we review the latest advances in the design of SGCs and discuss the main challenges ahead.
Vitamin D Status in Palindromic Rheumatism: A Propensity Score Matching Analysis
Authors: Khabbazi Alireza , Mahmoudi Maryam , Esalatmanesh Kamal , Asgari-Sabet Masoomeh , Safary Azam 
Published: May 2023

Abstract

Objective
To determine whether there is a correlation between vitamin D levels and palindromic rheumatism (PR) as an at-risk phenotype of rheumatoid arthritis (RA).

Methods
A total of 308 participants were enrolled in this cross-sectional study. We recorded their clinical characteristics and performed propensity-score matching (PSM). Serum 25(OH)D3 levels were determined via enzyme-linked immunosorbent assay.

Results
Our PSM resulted in 48 patients with PR and 96 matched control individuals. The multivariate regression analysis we performed after the PSM did not show a significant increase in PR risk in patients with vitamin D deficiency/insufficiency. There was no significant correlation between levels of 25(OH)D3 and frequency/duration of attacks, number of joints affected, and duration of symptoms before diagnosis (P ≥ .05). Mean (SD) serum levels of 25(OH)D3 in patients with and without progression to RA were 28.7 (15.9) ng/mL and 25.1 (11.4) ng/mL, respectively.

Conclusion
Based on the results, we found no clear association between vitamin D serum levels and the risk, severity, and rate of PR progressing into RA.
Meridional circulation driven by planetary spiral wakes in radiative and magnetized protoplanetary discs
Authors: Cilibrasi Marco , Flock Mario , Szulágyi Judit 
Published: May 2023

ABSTRACT
We study a Jupiter-mass planet formation for the first time in radiative magnetohydrodynamics (MHD) simulations and compare it with pure hydrodynamical simulations, and also with different isothermal configurations. We found that the meridional circulation is the same in every set-up. The planetary spiral wakes drive a vertical stirring inside the protoplanetary disc and the encounter with these shock fronts also helps in delivering gas vertically on to the Hill sphere. The accretion dynamics are unchanged: the planet accretes vertically, and there is outflow in the mid-plane regions inside the Hill sphere. We determined the effective α-viscosity generated in the disc by the various angular momentum loss mechanisms, which showed that magnetic fields produce high turbulence in the ideal MHD limit, and grows from α ∼ 10−2.5 up to ∼10−1.5 after the planet spirals develop. In the HD simulations, the planetary spirals contribute to α ∼ 10−3, making this a very important angular momentum transport mechanism. Due to the various α values in the different set-ups, the gap opening is different in each case. In the radiative MHD set-ups, the high turbulent viscosity prevents gap opening, leading to a higher Hill mass, and no clear dust trapping regions. While the Hill accretion rate is $10^{-6}~ \rm {M_{Jup}\,yr^{-1}}$ in all set-ups, the accretion variability is orders of magnitude higher in radiative runs than in isothermal ones. Finally, with higher resolution runs, the magnetorotational instability started to be resolved, changing the effective viscosity and increasing the heating in the disc.
A forecast for large-scale structure constraints on Horndeski gravity with CO line intensity mapping
Authors: Scott Bryan R , Karkare Kirit S , Bird Simeon 
Published: May 2023

ABSTRACT
We consider the potential for line intensity mapping (LIM) of the rotational CO(1-0), CO(2-1), and CO(3-2) transitions to detect deviations from General Relativity from 0 &lt; z &lt; 3 within the framework of a very general class of modified gravity models, called Horndeski’s theories. Our forecast assumes a multitracer analysis separately obtaining information from the matter power spectrum and the first two multipoles of the redshift space distortion power spectrum. To achieve ±0.1 level constraints on the slope of the kinetic gravity braiding and Planck mass evolution parameters, a mm-wave LIM experiment would need to accumulate ≈108–109 spectrometre-hours, feasible with instruments that could be deployed in the 2030s. Such a measurement would constrain the parameters of Horndeski’s theory at a level at worst competitive to and at best an order of magnitude tighter than existing constraints from the CMB and LSS. Our modelling code is publicly available.
Quantifying the influence of bars on action-based dynamical modelling of disc galaxies
Authors: Ghosh Soumavo , Trick Wilma H , Green Gregory M 
Published: May 2023

ABSTRACT
Action-based dynamical modelling, using stars as dynamical tracers, is an excellent diagnostic to estimate the underlying axisymmetric matter distribution of the Milky Way. However, the Milky Way’s bar causes non-axisymmetric resonance features in the stellar disc. Using RoadMapping (an action-based dynamical modelling framework to estimate the gravitational potential and the stellar distribution function), we systematically quantify the robustness of action-based modelling in the presence of a bar. We construct a set of test-particle simulations of barred galaxies (with varying bar properties), and apply RoadMapping to different survey volumes (with varying azimuthal position, size) drawn from these barred models. For realistic bar parameters, the global potential parameters are still recovered to within ∼1–17 per cent. However, with increasing bar strength, the best-fitting values of the parameters progressively deviate from their true values. This happens due to a combination of radial heating, radial migration, and resonance overlap phenomena in our bar models. Furthermore, the azimuthal location and the size of the survey volumes play important roles in the successful recovery of the parameters. Survey volumes along the bar major axis produce larger (relative) errors in the best-fitting parameter values. In addition, the potential parameters are better recovered for survey volumes with larger spatial coverage. As the Sun is located just ∼28°–33° behind the bar’s major axis, an estimate for the bar-induced systematic bias – as provided by this study – is therefore crucial for future modelling attempts of the Milky Way.
Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element
Authors: Ali Tamer , Rogala Sandra , Krause Nina M , Bains Jasleen Kaur , Melissari Maria-Theodora , Währisch Sandra , Schwalbe Harald , Herrmann Bernhard G , Grote Phillip 
Published: May 2023

Abstract
Long non-coding RNAs are a very versatile class of molecules that can have important roles in regulating a cells function, including regulating other genes on the transcriptional level. One of these mechanisms is that RNA can directly interact with DNA thereby recruiting additional components such as proteins to these sites via an RNA:dsDNA triplex formation. We genetically deleted the triplex forming sequence (FendrrBox) from the lncRNA Fendrr in mice and found that this FendrrBox is partially required for Fendrr function in vivo. We found that the loss of the triplex forming site in developing lungs causes a dysregulation of gene programs associated with lung fibrosis. A set of these genes contain a triplex site directly at their promoter and are expressed in lung fibroblasts. We biophysically confirmed the formation of an RNA:dsDNA triplex with target promoters in vitro. We found that Fendrr with the Wnt signalling pathway regulates these genes, implicating that Fendrr synergizes with Wnt signalling in lung fibrosis.
Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism
Authors: Tarrés-Solé Aleix , Battistini Federica , Gerhold Joachim M , Piétrement Olivier , Martínez-García Belén , Ruiz-López Elena , Lyonnais Sébastien , Bernadó Pau , Roca Joaquim , Orozco Modesto , Le Cam Eric , Sedman Juhan , Solà Maria 
Published: May 2023

Abstract
The compaction of mitochondrial DNA (mtDNA) is regulated by architectural HMG-box proteins whose limited cross-species similarity suggests diverse underlying mechanisms. Viability of Candida albicans, a human antibiotic-resistant mucosal pathogen, is compromised by altering mtDNA regulators. Among them, there is the mtDNA maintenance factor Gcf1p, which differs in sequence and structure from its human and Saccharomyces cerevisiae counterparts, TFAM and Abf2p. Our crystallographic, biophysical, biochemical and computational analysis showed that Gcf1p forms dynamic protein/DNA multimers by a combined action of an N-terminal unstructured tail and a long helix. Furthermore, an HMG-box domain canonically binds the minor groove and dramatically bends the DNA while, unprecedentedly, a second HMG-box binds the major groove without imposing distortions. This architectural protein thus uses its multiple domains to bridge co-aligned DNA segments without altering the DNA topology, revealing a new mechanism of mtDNA condensation.
Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease
Authors: Hasegawa Takeshi , Imaizumi Takahiro , Hamano Takayuki , Murotani Kenta , Fujii Naohiko , Komaba Hirotaka , Ando Masahiko , Maruyama Shoichi , Nangaku Masaomi , Nitta Kosaku , Hirakata Hideki , Isaka Yoshitaka , Wada Takashi , Fukagawa Masafumi 
Published: May 2023

ABSTRACT

Background
The optimal range of serum iron markers and usefulness of iron supplementation are uncertain in patients with pre-dialysis chronic kidney disease (CKD). We investigated the association between serum iron indices and risk of cardiovascular disease (CVD) events and the effectiveness of iron supplementation using Chronic Kidney Disease Japan Cohort data.

Methods
We included 1416 patients ages 20–75 years with pre-dialysis CKD. The tested exposures were serum transferrin saturation and serum ferritin levels and the outcome measures were any cardiovascular event. Fine–Gray subdistribution hazard models were used to examine the association between serum iron indices and time to events. The multivariable fractional polynomial interaction approach was used to evaluate whether serum iron indices were effect modifiers of the association between iron supplementation and cardiovascular events.

Results
The overall incidence rate of CVD events for a median of 4.12 years was 26.7 events/1000 person-years. Patients with serum transferrin saturation &lt;20% demonstrated an increased risk of CVD [subdistribution hazard ratio (HR) 2.13] and congestive heart failure (subdistribution HR 2.42). The magnitude of reduction in CVD risk with iron supplementation was greater in patients with lower transferrin saturations (P = .042).

Conclusions
Maintaining transferrin saturation &gt;20% and adequate iron supplementation may effectively reduce the risk of CVD events in patients with pre-dialysis CKD.
Sacubitril/valsartan ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse model of type 2 diabetes with aldosterone excess
Authors: Nishio Haruomi , Ishii Akira , Yamada Hiroyuki , Mori Keita P , Kato Yukiko , Ohno Shoko , Handa Takaya , Sugioka Sayaka , Ishimura Takuya , Ikushima Akie , Inoue Yui , Minamino Naoto , Mukoyama Masashi , Yanagita Motoko , Yokoi Hideki 
Published: May 2023

ABSTRACT

Background
Aldosterone has been assumed to be one of aggravating factors in diabetic kidney disease (DKD). Natriuretic peptides/guanylyl cyclase-A/cGMP signalling has been shown to ameliorate aldosterone-induced renal injury in mice. Sacubitril/valsartan (SAC/VAL) is used clinically for chronic heart failure and hypertension, in part by augmenting natriuretic peptide bioavailability. The effects of SAC/VAL on renal pathophysiology including in DKD, however, have remained unclarified.

Methods
Eight-week-old male db/db mice fed on a high-salt diet (HSD) were treated with vehicle or aldosterone (0.2 μg/kg/min), and divided into four groups: HSD control, ALDO (aldosterone), ALDO + VAL (valsartan), and ALDO + SAC/VAL group. After 4 weeks, they were analysed for plasma atrial natriuretic peptide (ANP) levels, renal histology, and haemodynamic parameters including glomerular filtration rate (GFR) by FITC-inulin and renal plasma flow (RPF) by para-amino hippuric acid.

Results
The ALDO + SAC/VAL group showed significantly increased plasma ANP concentration and creatinine clearance, and decreased tubulointerstitial fibrosis and neutrophil gelatinase-associated lipocalin expression compared to ALDO and ALDO + VAL groups. SAC/VAL treatment increased GFR and RPF, and suppressed expression of Tgfb1, Il1b, Ccl2, and Lcn2 genes compared to the ALDO group. The percentage of tubulointerstitial fibrotic areas negatively correlated with the RPF and GFR.

Conclusion
In a mouse model of type 2 diabetes with aldosterone excess, SAC/VAL increased RPF and GFR, and ameliorated tubulointerstitial fibrosis. Furthermore, RPF negatively correlated well with tubulointerstitial injury, suggesting that the beneficial effects of SAC/VAL could be through increased renal plasma flow with enhanced natriuretic peptide bioavailability.
Toddler milk: a scoping review of research on consumption, perceptions, and marketing practices
Authors: Richter Ana Paula C , Grummon Anna H , Falbe Jennifer , Taillie Lindsey Smith , Wallace Deshira D , Lazard Allison J , Golden Shelley D , Conklin Jamie L , Hall Marissa G 
Published: May 2023

Abstract
Toddler milk is an ultra-processed beverage consisting primarily of powdered milk, caloric sweeteners, and vegetable oil. Pediatric health authorities do not support the use of toddler milk, and emerging evidence suggests that toddler-milk marketing practices may mislead consumers. However, studies have not synthesized the extent of toddler-milk marketing practices or how these practices affect parents’ decisions about whether to serve toddler milk. We aimed to summarize the literature about toddler milk to identify what is known about: (1) parents’ toddler-milk purchasing and feeding behaviors, (2) toddler-milk marketing, and (3) how marketing practices influence parents’ beliefs and perceptions about toddler milk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), we systematically searched 8 databases (PubMed, APA PsycINFO, Scopus, Cochrane Central, Embase, CINAHL, Communication & Mass Media Complete, and Business Source Premier). We identified 45 articles about toddler milk. Studies were conducted in 25 countries across 6 continents. Five types of findings emerged: (1) consumption and feeding behaviors, (2) demographic correlates of toddler-milk purchasing and consumption, (3) misperceptions and beliefs, (4) increased sales, and (5) increased marketing and responses to marketing. The included articles suggested that toddler-milk sales are growing rapidly worldwide. Findings also revealed that toddler-milk packages (eg, labels, branding) resemble infant formula packages and that toddler-milk marketing practices may indirectly advertise infant formula. Purchasing, serving, and consumption of toddler milk were higher in Black and Hispanic populations than in non-Hispanic White populations, and parents with higher educational attainment and income were more likely to offer toddler milk to their children. Findings suggest a need for policies to prevent cross-marketing of toddler milk and infant formula, reduce provision of toddler milk to infants and toddlers, and prevent caregivers from being misled about toddler-milk healthfulness.
Unemployment insurance design with repeated choices
Authors: Kankanamge Sumudu , Weitzenblum Thomas 
Published: May 2023

Abstract
This article characterizes the relation between the equilibrium unemployment insurance replacement rate and the frequency of its political choice. We first use a tractable analytical model to show how insurance, incentive, and redistribution effects interact at the equilibrium. We then examine a fully repeated choices equilibrium in a quantitative heterogeneous agents model and show that unemployment persistence, whether a policy is announced first or not, and the type of the political process are key determinants of the relation between the equilibrium replacement rate and the frequency of its choice. In a utilitarian welfare context, we find that the equilibrium replacement rate is higher if the policy is chosen more frequently but this relation is reversed in a median voter context.
Nonlocal Kondo effect and two-fluid picture revealed in an exactly solvable model
Authors: Wang Jiangfan , Yang Yi-feng 
Published: May 2023

Abstract
Understanding the nature of local–itinerant transition of strongly correlated electrons is one of the central problems in condensed matter physics. Heavy fermion systems describe the f-electron delocalization through Kondo interactions with conduction electrons. Tremendous efforts have been devoted to the so-called Kondo-destruction scenario, which predicts a dramatic local-to-itinerant quantum phase transition of f-electrons at zero temperature. On the other hand, two-fluid behaviors have been observed in many materials, suggesting coexistence of local and itinerant f-electrons over a broad temperature range but lacking a microscopic theoretical description. To elucidate this fundamental issue, here we propose an exactly solvable Kondo-Heisenberg model in which the spins are defined in the momentum space and the k-space Kondo interaction corresponds to a highly nonlocal spin scattering in the coordinate space. Its solution reveals a continuous evolution of the Fermi surfaces with Kondo interaction and two-fluid behaviors similar to those observed in real materials. The electron density violates the usual Luttinger’s theorem, but follows a generalized one allowing for partially enlarged Fermi surfaces due to partial Kondo screening in the momentum space. Our results highlight the consequence of nonlocal Kondo interaction relevant for strong quantum fluctuation regions and provide important insight into the microscopic description of two-fluid phenomenology in heavy fermion systems.
Venous and arterial thromboembolic risk of Janus kinase inhibitors: a systematic review with meta-analysis
Authors: Campanaro Francesco , Zaffaroni Andrea , Cacioppo Elettra , Cappelli Antonella , Bertù Lorenza , Donadini Marco Paolo , Squizzato Alessandro , Batticciotto Alberto 
Published: May 2023

Abstract

Objective
Preliminary data led licencing authorities to alert clinicians of an increased venous thrombotic risk associated to the use of Janus kinase (JAK) inhibitors (JAKi). We performed a systematic review to estimate the risk of venous and arterial thrombosis associated to JAKi for the treatment of immune-mediated inflammatory diseases (IMIDs).

Methods
Randomized controlled trials (RCTs) on JAKi in patients with IMIDs were identified by the MEDLINE and EMBASE databases until October 2021. Risk of bias was assessed according to Cochrane criteria. The beta-binomial model was applied to calculate pooled odds ratio (OR) and corresponding 95% CI. The PROSPERO registration number is CRD42022324143.

Results
We have included one phase I, 21 phase II, three phase II–III and 36 phase III RCTs for a total of 19 443 patients in the JAKi group and 6354 in the control group. Thirty-one (unweighted rate 0.16%; 95% CI: 0.10, 0.21) events were reported in the JAKi group and 20 (unweighted rate 0.22%; 95% CI: 0.12, 0.32) in the control group in a mean follow-up of 16.8 weeks. IMID patients treated with JAKi did not have an increased thromboembolic risk compared with those treated with placebo (OR 0.82; 95% CI: 0.43, 1.56). No statistically different results were seen in subanalyses for each investigated IMID, drug and dosage.

Conclusion
JAKi do not increase thromboembolic risk compared with placebo in IMID patients enrolled in selected RCTs.