bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing interventions for adult patients undergoing cancer cardiotoxic therapy: Scoping review
Authors: Jesus Evelyn Barcelos , Cavalcanti Ana Carla Dantas , Oliveira Josiana Araujo 
Published: July 2023

AbstractPurposeTo identify nursing interventions for the management of adult patients undergoing cardiotoxic oncologic therapy.MethodsThis scoping review was performed in accordance with the JBI guidelines. The literature search took place between July and August 2022. Studies examining interventions for the management of adult cancer patients undergoing cardiotoxic therapy were included. The characteristics and results of the studies were synthesized and analyzed in a narrative way.FindingsIn the nine included studies, it was verified that the interventions were implemented to guide the actions of the health team in general rather than specifically nursing staff. Nine nursing interventions related to the Classification of Nursing Interventions were included.ConclusionsThe nursing interventions identified focused on rigorous cardiovascular surveillance, risk assessment, and actions to identify and mitigate cardiotoxicity.Implications for Nursing PracticeIt is believed that the implementation of the identified nursing interventions will lead to evidence‐based nursing practice and will contribute to the development of care products and processes that assess the cardiological risks and cardiotoxicity.
Greece: Political Developments and Data in 2022
Authors: MYLONAS HARRIS 
Published: July 2023

AbstractThe year 2022 was marked by the onset of Russia's invasion of Ukraine. In February, the Greek government was quick to respond in support of the Ukrainian people defending their homeland. The city of Mariupol, home to a significant Greek diasporic community, was at the epicenter of the public's attention. Energy prices skyrocketed because of the war. Inflation, which was already at 5 per cent—the highest point in a decade—by the end of 2021, continued to soar reaching 12 per cent in the summer and an overall 7.2 per cent by the end of the year. Gross domestic product per capita increased at a faster rate than expected, but the trade deficit of the country also increased dramatically. The government continued to deal with the devastating impact of the pandemic. In May, Prime Minister (PM) Mitsotakis became the first Greek head of government to address a joint session of the US Congress at a time when Greek–Turkish relations deteriorated. In July, a wiretapping scandal targeting one of the opposition leaders, but also journalists, shook the political system and unseated the head of the National Intelligence Service, as well as the PM's general secretary, who was overseeing the agency. In December, Member of the European Parliament Eva Kaili was arrested and jailed in a Belgian prison as part of the so‐called Qatargate scandal. The ruling party, New Democracy, remained hegemonic. The main opposition party, the Coalition of the Radical Left, SYRIZA, continued to struggle. Finally, a staggering number of femicides occurred in 2022, 16 in total.
E‐cigarette support for smoking cessation: Identifying the effectiveness of intervention components in an on‐line randomized optimization experiment
Authors: Kimber Catherine , Sideropoulos Vassilis , Cox Sharon , Frings Daniel , Naughton Felix , Brown Jamie , McRobbie Hayden , Dawkins Lynne 
Published: July 2023

AbstractAims, Design and SettingThe aim of this study was to determine which combination(s) of five e‐cigarette‐orientated intervention components, delivered on‐line, affect smoking cessation. An on‐line (UK) balanced five‐factor (2 × 2 × 2 × 2 × 2 = 32 intervention combinations) randomized factorial design guided by the multi‐phase optimization strategy (MOST) was used.ParticipantsA total of 1214 eligible participants (61% female; 97% white) were recruited via social media.InterventionsThe five on‐line intervention components designed to help smokers switch to exclusive e‐cigarette use were: (1) tailored device selection advice; (2) tailored e‐liquid nicotine strength advice; (3): tailored e‐liquid flavour advice; (4) brief information on relative harms; and (5) text message (SMS) support.MeasurementsThe primary outcome was 4‐week self‐reported complete abstinence at 12 weeks post‐randomization. Primary analyses were intention‐to‐treat (loss to follow‐up recorded as smoking). Logistic regressions modelled the three‐ and two‐way interactions and main effects, explored in that order.FindingsIn the adjusted model the only significant interaction was a two‐way interaction, advice on flavour combined with text message support, which increased the odds of abstinence (odds ratio = 1.55, 95% confidence interval = 1.13–2.14, P = 0.007, Bayes factor = 7.25). There were no main effects of the intervention components.ConclusionsText‐message support with tailored advice on flavour is a promising intervention combination for smokers using an e‐cigarette in a quit attempt.
Quantitative analysis of the distribution of the myenteric plexus in the rabbit large intestine
Authors: Kigata Tetsuhito , Koyama Tatsuhiro , Lu Xizi , Shibata Hideshi 
Published: July 2023

AbstractRabbit large intestine has a segment‐specific morphology and motility. However, the morphological features of the myenteric plexus, which controls intestinal motility, have not been characterized in each large intestinal segment. We investigated the myenteric plexus morphology in the rabbit large intestine using protein gene product 9.5 immunohistochemistry in whole‐mount preparations. The tenial part of the first and second segments of the proximal colon had the most well developed myenteric plexus, while the caecum had the least. These findings suggest different neuronal control over the motility of each intestinal segment, thereby providing a fundamental understanding of the rabbit enteric nervous system.
Stratification economics in the land of persistent inequalities
Authors: Monroy‐Gómez‐Franco Luis , Villagómez‐Ornelas Paloma 
Published: July 2023

AbstractStratification economics has emerged as a field that puts historically and institutionally determined intergroup hierarchies at the forefront of distributive analysis. However, most of the existing theoretical and empirical literature has focused on studying the US stratification regime, limiting the potential application of this analytical framework to other geographies. This paper applies the theoretical framework of stratification economics to analyze the Mexican distributive regime. In the process, we show that expanding the regional focus of stratification economics requires incorporating several insights from other traditions of stratification analysis. Furthermore, we show that a stratification economics approach overcomes several pitfalls of more traditional approaches to analyzing the Mexican distributive regime, such as the human capital approach that anchored several public policy interventions deployed at the beginning of the XXIst century.
Improved ambient air quality is associated with decreased prevalence of childhood asthma and infancy shortly after weaning is a sensitive exposure window
Authors: Chen Tianyi , Shi Su , Li Xinyue , Zhou Lu , Yu Yongfu , Cai Yunfei , Wang Jing , Kan Haidong , Xu Yanyi , Huang Chen , Tan Yongqiang , Meng Xia , Zhao Zhuohui 
Published: July 2023

AbstractBackgroundThe urban ambient air quality has been largely improved in the past decade. It is unknown whether childhood asthma prevalence is still increasing in ever top‐ranking city of Shanghai, whether the improved air quality is beneficial for children's asthma and what time window of exposure plays critical roles.MethodsUsing a repeat cross‐sectional design, we analyzed the association between early life exposure to particles and wheezing/asthma in each individual and combined surveys in 2011 and 2019, respectively, in 11,825 preschool children in Shanghai.ResultsA significantly lower prevalence of doctor‐diagnosed asthma (DDA) (6.6% vs. 10.5%, p < 0.001) and wheezing (10.5% vs. 23.2%, p < 0.001) was observed in 2019 compared to 2011. Exposure to fine particulate matter (PM2.5), coarse particles (PM2.5–10) and inhalable particles (PM10) was decreased in 2019 by 6.3%, 35.4%, and 44.7% in uterus and 24.3%, 20.2%, and 31.8% in infancy, respectively. Multilevel log‐binomial regression analysis showed exposure in infancy had independent association with wheezing/DDA adjusting for exposure in uterus. For each interquartile range (IQR) increase of infancy PM2.5, PM2.5–10 and PM10 exposure, the odds ratios were 1.39 (95% confidence interval (CI): 1.24–1.56), 1.51 (95% CI:1.15–1.98) and 1.53 (95% CI:1.27–1.85) for DDA, respectively. The distributed lag non‐linear model showed the sensitive exposure window (SEW) was 5.5–11 months after birth. Stratified analysis showed the SEWs were at or shortly after weaning, but only in those with <6 months of exclusive breastfeeding.ConclusionsImproved ambient PM benefits in decreasing childhood asthma prevalence. We firstly reported the finding of SEW to PM at or closely after weaning on childhood asthma.
(Com)passionate Revanchism and the Role ofPrivate‐SectorCoalitions in the Spatial Management of Houselessness
Authors: Anderson Matthew B. , Staal Anna , Mutungi Della , Gower Katie , Agyei Christabel 
Published: July 2023

AbstractThe study examines compassionate revanchism as a contemporary feature of houseless management in the context of an emergent phenomenon: the formation of private‐sector coalitions as coordinating leaders in houseless management. We deconstruct compassionate revanchist discourse through a comparative analysis between the Oregon Harbor of Hope in Portland, OR, and the Hello for Good Coalition in Spokane, WA. As such, the study responds to recent calls for more research on under‐studied cities such as Spokane, where rates of houselessness have spiked in recent years. In the process, it critically examines recent proclamations of an emergent “post‐revanchist” city and concludes by arguing that we are currently at a crossroads whereby the impulse to “take back the city” for propertied interests is either compassionately tempered and/or passionately reinvoked, and that the practices taken by such private‐sector coalitions, and how genuinely compassionate they are, manifest in variegated ways across socio‐spatial contexts.
Current status and future potential of ex vivo lung perfusion in clinical lung transplantation
Authors: Zhou Alice L. , Larson Emily L. , Ruck Jessica M. , Ha Jinny S. , Casillan Alfred J. , Bush Errol L. 
Published: July 2023

AbstractLung transplantation is accepted as a well‐established and effective treatment for patients with end‐stage lung disease. While the number of candidates added to the waitlist continues to rise, the number of transplants performed remains limited by the number of suitable organ donors. Ex vivo lung perfusion (EVLP) emerged as a method of addressing the organ shortage by allowing the evaluation and potential reconditioning of marginal donor lungs or minimizing risks of prolonged ischemic time due to logistical challenges. The currently available FDA‐approved EVLP systems have demonstrated excellent outcomes in clinical trials, and retrospective studies have demonstrated similar post‐transplant survival between recipients who received marginal donor lungs perfused using EVLP and recipients who received standard criteria lungs stored using conventional methods. Despite this, widespread utilization has plateaued in the last few years, likely due to the significant costs associated with initiating EVLP programs. Centralized, dedicated EVLP perfusion centers are currently being investigated as a potential method of further expanding utilization of this technology. In the preclinical setting, potential applications of EVLP that are currently being studied include prolongation of organ preservation, reconditioning of unsuitable lungs, and further enhancement of already suitable lungs. As adoption of EVLP technology becomes more widespread, we may begin to see future implementation of these potential applications into the clinical setting.
Analyzing Clustered Continuous Response Variables with Ordinal Regression Models
Authors: Tian Yuqi , Shepherd Bryan E. , Li Chun , Zeng Donglin , Schildcrout Jonathan S. 
Published: July 2023

AbstractContinuous response data are regularly transformed to meet regression modeling assumptions. However, approaches taken to identify the appropriate transformation can be ad hoc and can increase model uncertainty. Further, the resulting transformations often vary across studies leading to difficulties with synthesizing and interpreting results. When a continuous response variable is measured repeatedly within individuals or when continuous responses arise from clusters, analyses have the additional challenge caused by within-individual or within-cluster correlations. We extend a widely used ordinal regression model, the cumulative probability model (CPM), to fit clustered, continuous response data using generalized estimating equations for ordinal responses. With the proposed approach, estimates of marginal model parameters, cumulative distribution functions, expectations, and quantiles conditional on covariates can be obtained without pretransformation of the response data. While computational challenges arise with large numbers of distinct values of the continuous response variable, we propose feasible and computationally efficient approaches to fit CPMs under commonly used working correlation structures. We study finite sample operating characteristics of the estimators via simulation and illustrate their implementation with two data examples. One studies predictors of CD4:CD8 ratios in a cohort living with HIV, and the other investigates the association of a single nucleotide polymorphism and lung function decline in a cohort with early chronic obstructive pulmonary disease.
Incidence and predictors of hypophosphataemia after ferric carboxymaltose use—A 3‐year experience from a single institution in Singapore
Authors: Chu Zachary , Cushway Tim , Wong Marc , Lim Kai‐Xiong , Peh Wee‐Ming , Ng Choong‐Tatt , Lim Wan‐Yen , Ong Sharon G. K. , Tey Tze‐Tong , Foo Fung‐Joon , Koh Frederick H. 
Published: July 2023

SummaryFerric carboxymaltose (FCM) administration helps reduce transfusion requirements in the perioperative situation, which improves patient outcomes and reduces healthcare costs. However, there is increasing evidence of hypophosphataemia after FCM use. We aim to determine the incidence of hypophosphataemia after FCM administration and elucidate potential biochemical factors associated with the development of subsequent hypophosphataemia. A retrospective review of anonymised data of all FCM administrations in a single institution was conducted from August 2018 to August 2021. Each unique FCM dose administered was examined to assess its effect on Hb and serum phosphate levels within the subsequent 28 days from each FCM administration. Phosphate levels were repeatedly measured within the 28‐day interval and the lowest phosphate level within that period was determined. Patients' serum phosphate levels within 28 days of FCM administration were compared against normal serum phosphate levels within 2 weeks before FCM administration. The odds ratios of various pre‐FCM serum markers were calculated to elucidate potential biochemical predictors of post‐FCM hypophosphataemia. In 3 years, a total of 1296 doses of FCM were administered to 1069 patients. The mean improvement in Hb was 2.45 g/dL (SD = 1.94) within 28 days of FCM administration, with the mean time taken to peak Hb levels being 6.3 days (SD = 8.63), which is earlier than expected, but was observed in this study and hence reported. The incidence of hypophosphataemia <0.8 mmol/L was 22.7% (n = 186), and <0.4 mmol/L was 1.6% (n = 9). This figure is lower than the numbers reported in previously published meta‐analyses given that routine checks of serum phosphate levels were not conducted initially and hence could possibly be higher. The odds of developing hypophosphataemia (<0.8 mmol/L) were 27.7 (CI: 17.3–44.2, p < 0.0001) if baseline serum phosphate was less than 1 mmol/L. The odds of developing hypophosphataemia (<0.8 mmol/L) were 1.3 (CI: 1.08–1.59, p < 0.01) if the change in Hb levels observed after FCM administration were more than 4 g/dL. Hypophosphataemia after FCM administration is significant and FCM should be used by clinicians with caution.
Real‐world evidence of incidence and outcomes of aplastic anaemia following administration of immune checkpoint inhibitors
Authors: Dasari Srilatha , Tse William , Wang Jiasheng 
Published: July 2023

SummaryAplastic anaemia (AA) is a rare immune‐related adverse events (irAEs) after immune checkpoint inhibitors (ICIs) administration with poorly understood incidence and outcomes. We analysed an electronic health record database of 52 303 ICI‐treated patients and found 77 (0.15%) cases of AA, with a median onset of 126 days (interquartile range, 58–363 days). The most used treatment for AA was systemic glucocorticoids 60 (77.9%) and 32 (41.6%) patients were able to resume ICI within 1 year. Patients diagnosed with AA had a steep decline in overall survival (OS) within the first 120 days; when compared to propensity score‐matched patients without AA, they had a significantly worse OS (hazard ratio 1.72, 95% confidence interval 1.19–2.50; p = 0.003).
Amentoflavone attenuates cell proliferation and induces ferroptosis in human gastric cancer by miR‐496/ATF2 axis
Authors: Tang Fengying , Xu Yongpan , Gao Erpeng , Zhang Wei , Zhang Fengli , Xiang Yi , Xu Lixiaoyuan , Dong Fen 
Published: July 2023

AbstractAmentoflavone (AF) is a natural multifunctional biflavonoid that has been revealed to possess multiple biological activities, including anticancer activity. Here, this work focused on exploring the functions and mechanism of AF in gastric cancer (GC). Levels of genes and proteins were examined by quantitative real‐time PCR and western blotting. Cell proliferation and cell death were analyzed using cell counting kit‐8, colony formation, and lactate dehydrogenase (LDH) release assay, respectively. Cell ferroptosis was evaluated by detecting the levels of malondialdehyde (MDA), reduced glutathione (GSH), Fe2+, and intracellular reactive oxygen species (ROS). The binding between miR‐496 and activating transcription factor 2 (ATF2) was confirmed by using dual‐luciferase reporter assay. Murine xenograft assay was conducted for in vivo experiments. The results showed that AF suppressed the proliferation and induced ferroptotic cell death in GC cells. MiR‐496 expression was decreased in GC tissues and cells, and AF treatment increased miR‐496 expression level in GC cells. Functionally, miR‐496 inhibition reversed the inhibitory effects of AF on GC cell proliferation and promoting effects on ferroptotic cell death. Mechanistically, ATF2 was targeted by miR‐496. ATF2 expression was increased in GC tissues and cells, which was decreased by AF treatment and subsequently rescued by miR‐496 downregulation in GC cells. Moreover, miR‐496 overexpression suppressed the proliferation and induced ferroptotic cell death in GC cells via targeting ATF2. In all, AF suppressed the proliferation and induced ferroptotic cell death in GC cells via miR‐496/ATF2 axis, indicating a novel therapeutic approach for GC patients.
Treating children's aggressive behavior problems using cognitive behavior therapy with virtual reality: A multicenter randomized controlled trial
Authors: Alsem Sophie C. , van Dijk Anouk , Verhulp Esmée E. , Dekkers Tycho J. , De Castro Bram O. 
Published: July 2023

AbstractThis multicenter randomized controlled trial investigated whether interactive virtual reality enhanced effectiveness of Cognitive Behavioral Therapy (CBT) to reduce children's aggressive behavior problems. Boys with aggressive behavior problems (N = 115; Mage = 10.58, SD = 1.48; 95.7% born in Netherlands) were randomized into three groups: CBT with virtual reality, CBT with roleplays, or care‐as‐usual. Bayesian analyses showed that CBT with virtual reality more likely reduced aggressive behavior compared to care‐as‐usual for six of seven outcomes (ds 0.19–0.95), and compared to CBT with roleplays for four outcomes (ds 0.14–0.68). Moreover, compared to roleplays, virtual reality more likely enhanced children's emotional engagement, practice immersion, and treatment appreciation. Thus, virtual reality may be a promising tool to enhance CBT effectiveness for children with aggressive behavior problems.
Association between abdominal muscle stiffness, diaphragm thickness and peak expiratory flow in younger versus older adults
Authors: Lim Youngeun , Do Yerim , Lee Haneul 
Published: July 2023

AbstractThe present study aimed to evaluate forced expiration based on transverse abdominis (TrA) stiffness by identifying the relationship between TrA stiffness and peak expiratory flow (PEF) in both younger and older adults. We also assessed the relationship between diaphragm thickness and PEF. A total of 31 younger (21.24 ± 2.73 years) and 34 older (71.35 ± 5.26 years) adults were included in the present study. TrA muscle stiffness was measured at rest and during abdominal bracing using shear wave elastography. Diaphragm thickness was measured during deep inspiration and expiration using B‐mode ultrasound, and respiratory function was assessed by measuring PEF using a spirometer. We found that TrA stiffness during bracing was significantly lower in older than younger adults (p < 0.05). Similarly, the difference in absolute stiffness of the TrA when bracing versus at rest was significantly lower in older than younger adults (p < 0.05). Additionally, TrA stiffness during bracing was positively associated with PEF in the younger group (r = 0.483), while a very weak correlation was found in the older group (r = 0.172). Similarly, PEF was moderately correlated with diaphragm thickness during expiration as well as during changes between inspiration and expiration in the younger group (r = 0.405 and r = 0.403); however, no significant correlation was found in the older group. These findings of the present study indicate that the variations in PEF between younger and older adults may be due to age‐associated changes in the musculoskeletal structure and muscle fibre type.
Environmental tax incentives and corporate environmental behaviour: An unintended consequence from a natural experiment in China
Authors: Boubaker Sabri , Cheng Feiyang , Liao Jing , Yue Shuai 
Published: July 2023

AbstractUsing the implementation of the Environmental Protection Tax (EPT) Law in China as a natural experiment, we explore the impact of environmental tax incentives on corporate environmental engagement. Evidence shows that, after the implementation of the EPT Law, there exists a significant improvement in the environmental performance of firms located in regions with increased EPT rates. However, our results reveal an unintended consequence that this effect is more salient for nonheavy‐polluting companies rather than for heavy polluters that are more targeted by the EPT Law.