bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating scent communication and latrine use to inform translocation of the Tasmanian devil
Authors: Shier Debra M. , Grether Gregory F. , Reid-Wainscoat Elizabeth E. , Fox Samantha , Pemberton David , Elmer Jodie , Swaisgood Ronald R. 
Published: August 2023

Abstract
Translocation programs for endangered mammalian carnivores face numerous challenges, including the potential for lethal interactions between releasees and resident conspecifics. Here we evaluate whether familiarizing residents with the scent of releasees might be an effective strategy for reducing aggression following Tasmanian devil (Sarcophilus harrisii) translocation. Tasmanian devils live in loose social networks in which residents have overlapping home ranges and use communal latrines. In a controlled ex situ experiment, we first found that devils readily distinguished between the feces of familiar and unfamiliar conspecifics. Next, we swapped feces between devils slated for release and wild resident devils, seeding a random half of communal latrines in the wild with the feces of releasee prior to their release, and used motion-activated video cameras to record devil visits. Wild resident devil visitation frequency and olfactory communication behaviors initially increased at experimental latrine sites where feces were deposited but not at control sites. After release, the translocated devils used both types of latrine sites and spent more time investigating experimental sites, but investigatory and scent-marking behaviors of the wild resident devils decreased, suggesting that they had become familiar with the releasees through scent. We further show that Tasmanian devil latrine sites are strongly associated with ecotones and the presence of shrubs. These findings contribute to our understanding of Tasmanian devil scent ecology and suggest that devil translocations conducted into existing populations would benefit from familiarization through latrine scent manipulation. More broadly, our results suggest an important role for scent ecology in carnivore translocation programs.

Significance statement
A conservation management action that is being trialed for endangered Tasmanian devils is to breed devils in human care and reinforce dwindling small resident populations through translocation. However, with limited social interactions, unfamiliar devils may interact aggressively, increasing injury and reducing translocation success. Scent communication is nearly ubiquitous in mammals and may be a prerequisite for management of social aggression. Almost nothing is known about devil scent ecology. Our discovery that devils become familiarized with conspecifics through feces, combined with findings that wild devils that are exposed to translocated devil scent in advance of release show reduced interest in scent-seeded latrines, even after new devils are released, suggests that devils familiarized through scent in advance of relocation may exhibit reduced aggression. These results provide an avenue for improving the success of translocations for devils and other at-risk solitary mammalian carnivores.
Digital holographic microscopy for measurement of instantaneous contact angle of an evaporating droplet
Authors: Asl Mohammad Mehdi Zamani , Dorao Carlos A. , Giacomello Alberto , Fernandino Maria 
Published: August 2023

AbstractDespite the apparent simplicity of the process of a droplet evaporating on a substrate, the temporal evolution of the local contact angle along the droplet periphery during the evaporation is still not fully understood. In this work, digital holographic microscopy is used for capturing the time evolution of the droplet surface at submicron resolution. The three-dimensional surface provides the information for determining the instantaneous three-phase contact line and the local apparent contact angle along the whole droplet periphery. The apparent contact angle is computed from the gradient of the droplet surface and defined as the maximum slope of this function along the periphery of the droplet. The method is then applied to study the diffusion dominated evaporation of nanoliter droplets on a hydrophilic substrate. For the case of a non-axisymmetric droplet, differences of up to 10$$^\circ$$

∘

in contact angle along the contact line were identified when the contact line went from one pinning position to another. Digital holographic microscopy allowed us to characterize the irregular motion of the contact line and local changes in contact angle during the evaporation process.
Prediction in regression models with continuous observations
Authors: Dette Holger , Pepelyshev Andrey , Zhigljavsky Anatoly 
Published: August 2023

AbstractWe consider the problem of predicting values of a random process or field satisfying a linear model $$y(x)=\theta ^\top f(x) + \varepsilon (x)$$

y

(
x
)

=

θ
⊤

f

(
x
)

+
ε

(
x
)

, where errors $$\varepsilon (x)$$

ε
(
x
)

are correlated. This is a common problem in kriging, where the case of discrete observations is standard. By focussing on the case of continuous observations, we derive expressions for the best linear unbiased predictors and their mean squared error. Our results are also applicable in the case where the derivatives of the process y are available, and either a response or one of its derivatives need to be predicted. The theoretical results are illustrated by several examples in particular for the popular Matérn 3/2 kernel.
Closure rates and patterns after light silicone oil tamponade for persistent full-thickness macular holes
Authors: Innauer Felix , Gabriel Maximilian , Mayer-Xanthaki Christoph , Haas Anton 
Published: August 2023

Abstract
Purpose
To report outcomes of re-vitrectomy using light silicone oil (SO) tamponade for persistent macular holes (MHs).

Methods
We reviewed cases of patients with full-thickness MHs that underwent pars plana vitrectomy (PPV) with air/gas and were re-vitrectomized using light SO tamponade after primary non-closure (persistent MHs). Outcome measures included anatomic closure rates and patterns confirmed by optical coherence tomography (OCT) and changes in best-corrected visual acuity (BCVA).

Results
A total of 42 eyes of 41 patients with unsuccessful primary PPV with air/gas were included. After re-vitrectomy with light SO (1000-centistoke), 29 (69%) eyes demonstrated type 1 closure without neurosensory defects in OCT scans, whereas 9 eyes (21%) showed type 2 closure with persisting neurosensory defects. Available data (n = 21) showed a significant mean improvement of BCVA from 0.99 logMAR (SD 0.25, range 0.7–1.3) preoperatively to 0.74 logMAR (SD 0.42, range 0.2–1.5) postoperatively (p = 0.035).

Conclusion
The treatment of persistent MHs with PPV and light SO tamponade resulted in high closure rates.
Survival after combined resection and ablation is not inferior to that after resection alone, in patients with four or more colorectal liver metastases
Authors: Amygdalos Iakovos , Hitpass Lea , Schmidt Felix , Josephs Gerrit , Bednarsch Jan , Berres Marie-Luise , Lüdde Tom , Olde Damink Steven W. M. , Ulmer Tom Florian , Neumann Ulf P. , Bruners Philipp , Lang Sven Arke 
Published: August 2023

Abstract
Purpose
Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer. Multimodal treatment strategies are frequently necessary to achieve total tumor elimination. This study examines the efficacy of liver resection combined with local ablative therapy in comparison to liver resection only, in the treatment of patients with ≥ 4 CRLM.

Methods
This retrospective cohort study was conducted at the University Hospital RWTH Aachen, Germany. Patients with ≥ 4 CRLM in preoperative imaging, who underwent curative resection between 2010–2021, were included. Recurrent resections and deaths in the early postoperative phase were excluded. Ablation modalities included radiofrequency or microwave ablation, and irreversible electroporation. Differences in overall- (OS) and recurrence-free-survival (RFS) between patients undergoing combined resection-ablation vs. resection only, were examined.

Results
Of 178 included patients, 46 (27%) underwent combined resection-ablation and 132 (73%) resection only. Apart from increased rates of adjuvant chemotherapy in the first group (44% vs. 25%, p = 0.014), there were no differences in perioperative systemic therapy. Kaplan–Meier and log-rank test analyses showed no statistically significant differences in median OS (36 months for both, p = 0.638) or RFS (9 months for combined resection-ablation vs. 8 months, p = 0.921). Cox regression analysis showed a hazard ratio of 0.891 (p = 0.642) for OS and 0.981 (p = 0.924) for RFS, for patients undergoing resection only.

Conclusion
For patients with ≥ 4 CRLM, combined resection-ablation is a viable option in terms of OS and RFS. Therefore, combined resection-ablation should be considered for complete tumor clearance, in patients with multifocal disease.
Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty
Authors: Liu Yuping , Cheng Yaying , Sun Meng , Hao Xiaojing , Li Mengmeng 
Published: August 2023

AbstractTo study the levels of serum insulin-like growth factor 1 (IGF-1), fibroblast growth factor 23 (FGF23), and Klotho, and to study their relationship with girls with rapidly progressive central precocious puberty (RP-CPP). This is a cross-sectional study on the progression rate of central precocious puberty in girls, who complained of breast development before the age of 8 years and were followed between June 2021 and June 2022. At the same time, 28 healthy girls less than 8 years old who had not started puberty were recruited as the control group. The physical examination and laboratory evaluation of each group was completed. Only patients with CPP received pelvic ultrasound examination and bone age test. Bone age index (BAI), basal LH levels (BLH), basal LH levels/basal FSH levels (BFSH), peak LH (PLH)/peak FSH (PFSH), IGF-1, Klotho, FGF23, and ovarian volume in the RP-CPP group were higher than those in slowly progressive CPP (SP-CPP) group. In the RP-CPP group, IGF-1 was correlated with Klotho, FGF23, and BLH; Klotho was correlated with FGF23 and BLH; FGF23 was correlated with BLH.Conclusion: The BLH, FGF23, Klotho, and IGF-1 have a certain correlation with RP-CPP, which may play an important role in the speed of girls’ sexual development.

What is Known:• The association between IGF-1 and RP-CPP.

What is New:• We found the association between FGF23, Klotho and RP-CPP.
Uptake of robot-assisted colon cancer surgery in the Netherlands
Authors: Sterk Marlou F. M. , Crolla Rogier M. P. H. , Verseveld Mareille , Dekker Jan Willem T. , van der Schelling George P. , Verhoef Cornelis , Olthof Pim B. 
Published: August 2023

Abstract
Background
The robot-assisted approach is now often used for rectal cancer surgery, but its use in colon cancer surgery is less well defined. This study aims to compare the outcomes of robotic-assisted colon cancer surgery to conventional laparoscopy in the Netherlands.

Methods
Data on all patients who underwent surgery for colon cancer from 2018 to 2020 were collected from the Dutch Colorectal Audit. All complications, readmissions, and deaths within 90 days after surgery were recorded along with conversion rate, margin and harvested nodes. Groups were stratified according to the robot-assisted and laparoscopic approach.

Results
In total, 18,886 patients were included in the analyses. The operative approach was open in 15.2%, laparoscopic in 78.9% and robot-assisted in 5.9%. The proportion of robot-assisted surgery increased from 4.7% in 2018 to 6.9% in 2020. There were no notable differences in outcomes between the robot-assisted and laparoscopic approach for Elective cT1-3M0 right, left, and sigmoid colectomy. Only conversion rate was consistently lower in the robotic group. (4.6% versus 8.8%, 4.6% versus 11.6%, and 1.6 versus 5.9%, respectively).

Conclusions
This nationwide study on surgery for colon cancer shows there is a gradual but slow adoption of robotic surgery for colon cancer up to 6.9% in 2020. When comparing the outcomes of right, left, and sigmoid colectomy, clinical outcomes were similar between the robotic and laparoscopic approach. However, conversion rate is consistently lower in the robotic procedures.
Stochastic virtual element methods for uncertainty propagation of stochastic linear elasticity
Authors: Zheng Zhibao , Nackenhorst Udo 
Published: August 2023

AbstractThis paper presents stochastic virtual element methods for propagating uncertainty in linear elastic stochastic problems. We first derive stochastic virtual element equations for 2D and 3D linear elastic problems that may involve uncertainties in material properties, external forces, boundary conditions, etc. A stochastic virtual element space that couples the deterministic virtual element space and the stochastic space is constructed for this purpose and used to approximate the unknown stochastic solution. Two numerical frameworks are then developed to solve the derived stochastic virtual element equations, including a Polynomial Chaos approximation based approach and a weakly intrusive approximation based approach. In the Polynomial Chaos based framework, the stochastic solution is approximated using the Polynomial Chaos basis and solved via an augmented deterministic virtual element equation that is generated by applying the stochastic Galerkin procedure to the original stochastic virtual element equation. In the weakly intrusive approximation based framework, the stochastic solution is approximated by a summation of a set of products of random variables and deterministic vectors, where the deterministic vectors are solved via converting the original stochastic problem to deterministic virtual element equations by the stochastic Galerkin approach, and the random variables are solved via converting the original stochastic problem to one-dimensional stochastic algebraic equations by the classical Galerkin procedure. This method avoids the curse of dimensionality in high-dimensional stochastic problems successfully since all random inputs are embedded into one-dimensional stochastic algebraic equations whose computational effort weakly depends on the stochastic dimension. Numerical results on 2D and 3D problems with low- and high-dimensional random inputs demonstrate the good performance of the proposed methods.
Pädiatrische stationäre interdisziplinäre multimodale Schmerztherapie in Deutschland
Authors: Wager Julia , Zernikow Boris 
Published: August 2023

Zusammenfassung
Hintergrund
Schwer beeinträchtigende chronische Schmerzen betreffen etwa eine halbe Million Kinder in Deutschland. Bei fehlendem Ansprechen auf eine unimodale Therapie kann eine stationäre interdisziplinäre multimodale Schmerztherapie (IMST) in Erwägung gezogen werden.

Ziel der Arbeit
In dieser Übersichtsarbeit wird die Versorgungslage der pädiatrischen stationären IMST in Deutschland beschrieben sowie aktuelle Evidenz zur Wirksamkeit dargestellt.

Material und Methoden
Mithilfe einer systematischen Literatursuche wurden Studien identifiziert, die sich mit der Wirksamkeit der pädiatrischen stationären IMST in Deutschland befassen. Zudem wurden weiterführende Quellen genutzt, um Informationen über IMST-Angebote in Deutschland, deren Behandlungsprogramme, die Qualifikation der Behandelnden und Charakteristika der Patient:innen zu beschreiben.

Ergebnisse
In Deutschland gibt es vier pädiatrische Schmerzzentren, die auf die stationäre IMST von Kindern und Jugendlichen spezialisiert sind. Die 3‑ bis 4‑wöchige multimodale Behandlung wird von einem multiprofessionellen Team angeboten und steht in der Regel Patient:innen bis zum 18. Lebensjahr zur Verfügung. Die Mehrzahl der Patient:innen ist weiblich. Die Wirksamkeit der pädiatrischen IMST in Deutschland wurde bis zu 4 Jahre nach der Behandlung untersucht. Positive Effekte zeigen sich sowohl für Schmerzeigenschaften als auch für die emotionale Belastung. Ergänzende Therapiemodule können die bestehenden Effekte noch weiter optimieren.

Schlussfolgerung
Weitere Forschung zur Wirksamkeit der IMST in Deutschland ist wichtig, um das Behandlungsangebot weiterentwickeln und optimieren zu können.
The reliability of posterior malleolar ankle fracture assessment: a unique perspective
Authors: Fűzy Edward Joseph , Ferreira Nando , Brown Craig , Hugo Daniel , Joubert Etienne , Burger Marilize 
Published: August 2023

Abstract
Aim
This study aims to elucidate the pathology of PMFs in the South African population, establish correlations between fracture patterns and international classification guidelines and evaluate the interobserver reliability of current classifications.

Methods
A retrospective review was conducted in a multicentre analysis over a one-year period from January 2019 to December 2019 at our institution. Computer tomography scans for foot and ankle injuries were reviewed, and posterior malleolus fractures were included. Pathoanatomical data was collected and analysed according to known classification systems and subsequent treatment modalities evaluated. A panel of observers individually reviewed radiographic data to determine interobserver reliability.

Results
A total of 71 patients were included with a mean age of 41 ± 13.4 years (range 18–78) and a female predominant population (69%). A greater proportion of injuries were high energy (23.9%), with significant fragment comminution (53.5%), and half (52.1%) of all injuries were subluxated/dislocated at presentation. A total of 93% of injuries were managed operatively, despite theatre access limitations resulting in significant delays to fixation (19.1 days). Despite good pathoanatomical agreement with most international classifications, interobserver reliability was poor (Krippendorff α-coefficient < 0.667). Inconsistent treatment patterns in operative and non-operative strategies are reported.

Conclusion
A unique patient population of younger, female individuals incurred posterior malleolar fractures due to higher energy mechanisms of injury. Whilst injury patterns were mostly comparable, significant interobserver variability was noted. Resource limitations, diagnostic challenges, poorly defined and inconsistent treatment strategies, inevitably impact outcomes within the South African population.

Level of evidence
Level III.
ROI: a method for identifying organizations receiving personal data
Authors: Rodriguez David , Del Alamo Jose M. , Cozar Miguel , García Boni 
Published: August 2023

AbstractMany studies have exposed the massive collection of personal data in the digital ecosystem through, for instance, websites, mobile apps, or smart devices. This fact goes unnoticed by most users, who are also unaware that the collectors are sharing their personal data with many different organizations around the globe. This paper assesses techniques available in the state of the art to identify the organizations receiving this personal data. Based on our findings, we propose Receiver Organization Identifier (ROI), a fully automated method that combines different techniques to achieve a 95.71% precision score in identifying an organization receiving personal data. We demonstrate our method in the wild by evaluating 10,000 Android apps and exposing the organizations that receive users’ personal data. We further assess the transparency of these data-sharing practices by analyzing the apps’ privacy policies. The results reveal a concerning lack of transparency in almost 78% of apps, suggesting the need for regulators to take action.
Hidden history of the tobacco BY-2 cell line
Authors: Nagata Toshiyuki 
Published: August 2023

AbstractFor almost 50 years, tobacco (Nicotiana tabacum) BY-2 cells have been widely recognized as an important cell line for plant biology. The cell line grows rapidly, can be synchronized to a high degree, and is excellent for imaging; over the years, these features have led to many high-impact discoveries. However, certain other uses of this cell line are virtually unknown. In the early days, I was involved in distributing the cells to laboratories around the world. Many of these scientists wanted to study the cell cycle; however, I also distributed the cells to scientists who were elucidating the mechanism of plant transformation by Agrobacterium tumefaciens. In fact, BY-2 cells played an essential role in the identification and analysis of Vir genes on the Ti plasmid; likewise, the cells were important for discovering the factor that induces the expression of Vir genes. Thus, BY-2 cells were crucial for the development of modern plant biotechnology. Here, I recount the story of how this came to pass and explain why the use of BY-2 cells in this work was never recognized.
Solving linear multiplicative programs via branch-and-bound: a computational experience
Authors: Cambini R. , Riccardi R. , Scopelliti D. 
Published: August 2023

AbstractIn this paper, linear multiplicative programs are approached with a branch-and-bound scheme and a detailed computational study is provided. Several underestimation functions are analyzed and various partitioning criteria are presented. A particular class of linear multiplicative programs, useful to solve some applicative bilevel problems, is considered from a theoretical point of view to emphasize an efficient solution method. Detailed results of the computational study are provided to point out the performances provided by using various underestimation functions and partitioning criteria, thus improving some of the results of the current literature.
Home range sizes of red deer in relation to habitat composition: a review and implications for management in Sweden
Authors: Jarnemo Anders , Nilsson Lovisa , Wikenros Camilla 
Published: August 2023

AbstractKnowledge about deer spatial use is essential for damage mitigation, conservation, and harvest management. We assess annual and seasonal home range sizes in relation to habitat composition for red deer (Cervus elaphus) in Sweden, using GPS-data from two regions with different management systems. We compare our findings with reviewed data on red deer home range sizes in Europe. Annual and seasonal home ranges during calving, hunt, and winter-spring, decreased with increasing proportion forest. Female annual home ranges in a mixed agricultural-forest landscape were three times larger than in a forest-dominated landscape. Core areas (50% Kernels) were approximately 1/5 of the full annual and seasonal home ranges (95% Kernels) regardless of habitat composition. Home range size in the forest-dominated landscape showed little inter-seasonal variation. In the agricultural-forest landscape, home ranges were larger during calving, hunt, and winter-spring compared to summer and rut. In the forest-dominated landscape, management areas are large enough to cover female spatial use. In the agricultural-forest landscape, female spatial use covers several license units. Here, the coordinated license system is needed to reach trade-offs between goals of conservation, game management, and damage mitigation. Males had in general larger home ranges than females, and the majority of the males also made a seasonal migration to and from the rutting areas. The license system area in the agricultural-forest landscape is large enough to manage migrating males. In the forest landscape, a coordination of several management areas is needed to encompass male migrations. We conclude that management needs to adapt to deer spatial use in different types of landscapes to reach set goals.