bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENCE OF SUBCLINICAL ATHEROSCLEROSIS IN YOUNG HYPERTENSIVES
Authors: Gragera Fernando 
Published: June 2023

Objective:
Evaluate the structure and arterial function in young hypertensive patients and determine the prevalence increase of EIM and atherosclerotic plaques: degree, location, total burden and its relation with pulse wave velocity.

Design and method:
An observational study was carried out transversally, at a population between 20 and 50 years old. The arterial evaluation has been done with a transductor lineal of 10MHZ ultrasound scanner. Measurement of endothelial function was performed by flow-mediated vasodilatation in the humeral artery. Continuous variables are presented as medium and standard deviation percentages. The comparation of variables between groups were carried on with T students. To compare the distribution of categorical variables, Chi square was operated. Pearson's correlation coefficient was used for the relation between VOP and other continuous numerical variables. A P<0.05 was considered significant.

Results:
Between September of 2020 and December of 2021, 150 patients were studied, 35 of which were comprehended from 20 to 50 years of age inclusive. The age was 43,3 years (from 25 to 50 years), 19 were male (59%) and 13 were female (39%). The body mass index was 29.9 +- 4.86 (21-39.4) with a prevalence of overweight of 22% (7 patients) and obesity of 47% (15 patients). 14 patients (44%) dyslipidemia, 1 patient (3%) Diabetes mellitus, 2 patients (6,3%) hypothyroidism, 2 patients (6.3%) cerebral vascular accident and 2 patients (6.3%) active smoking. Among all patients, 87,5% of them (28 patients) presented in at least one arterial territory EIM equal or higher to percentile 75. Atherosclerotic plaque was observed in 12 patients (37,5%) Endothelial function was decreased in 16 patients (50%) and pulse wave velocity was abnormal in 4 patients (12.5%). Cardiovascular risk was estimated in 10 years according to Framingham; 84.3% (27 patients) showed a low risk and plaque in 42% (8 patients). The 15.6% (5 patients) showed intermediate risk and plaque in 80% (4 patients).

Conclusions:
The prevalence of subclinical atherosclerosis in young hypertensive patients with low and moderate risk is high, has very poor correlation with risk scores, and has a clear correlation with alterations in arterial function.
ASSOCIATION OF METABOLIC SYNDROME AND HYPERTENSION IN A MOROCCAN POPULATION
Authors: Zahidi Hatim Amine , Badaoui Karim , Haboub Meryem , Arous Salim , Bennouna El Ghali , Drighil Abdenasser , Azzouzi Leila , Habbal Rachida 
Published: June 2023

Objective:
The metabolic syndrome (MS) is an emerging entity that groups together several metabolic abnormalities in the same individual that predispose to cardiovascular risk. However, among hypertensive patients, cardiovascular diseases are the main cause of mortality, and the prevalence of MS is not well known. We aim to estimate the prevalence of MS and its associated factors in a sample of patients with hypertension.

Design and method:
A cross-sectional study including 352 patients with arterial hypertension (> 20 years), The following measurements were performed: blood pressure; Body mass index (BMI); Plasma glucose and lipid levels. Blood pressure criteria was mean systolic blood pressure > 140 mmHg and/or diastolic arterial pressure > 90 mmHg; and the diagnosis of metabolic syndrome was retained according to WHO criteria and NCEP-ATP III criteria.

Results:
352 hypertensive patients, 76 % of whom were women, with a mean age of 60 ± 10 years were analyzed.
The prevalence of metabolic syndrome was 71%, mainly in women. Central obesity was the most frequent component of metabolic syndrome, accounting for 74% of patients (17% of men and 83% of women). Among the other components, low HDL-C was present in 63 % (22% of men and 78% of women), hyperglycemia in 70 % (16% of men and 84% of women), and high triglycerides in 67% (21% of men and 79% of women).

Conclusions:
The prevalence of metabolic syndrome is high in patients with hypertension. This underscores the importance of routine screening of hypertensive patients for other risk factors for cardiovascular disease.
BLOOD PRESSURE AND CARDIOVASCULAR RISK IN RELATION TO BIRTH WEIGHT AND URINARY SODIUM: AN INDIVIDUAL-PARTICIPANT META-ANALYSIS OF EUROPEAN FAMILY-BASED POPULATION STUDIES
Authors: Yu Yuling , Moliterno Paula , An Dewei , Raaijmakers Anke , Martens Dries , Stolarz-Skrzypek Katarzyna , Tikhonoff Valérie , Malyutina Sofia , Casiglia Edoardo , Chori Babangida , Filipovský Jan , Rajzer Marek , Allegaert Karel , Kawecka-Jaszcz Kalina , Verhamme Peter , Nawrot Tim , Staessen Jan , Boggia José 
Published: June 2023

Objective:
While the relation of salt intake with blood pressure (BP) is linear, it is U shaped for mortality and cardiovascular disease (CVD). This individual-participant meta-analysis explored whether the relation of hypertension, death or CVD with 24 h urinary sodium excretion (UVNA) or sodium-to-potassium (UNAK) ratio was modified by birth weight (BW).

Design and method:
Families were randomly enrolled in the Flemish Study on Genes, Environment and Health Outcomes (1985-2004) and the European Project on Genes in Hypertension (1999-2001). Categories of BW, UVNA and UNAK (< = 2500, >2500-4000, >4000 g; <2.3, 2.3-4.6 and >4.6 g; and <1, 1-2, >2, respectively) were coded using deviation-from-mean coding and analyzed by Kaplan-Meier survival functions and linear and Cox regression.

Results:
The study population was subdivided into the Outcome (n = 1945), Hypertension (n = 1460) and BP cohorts (n = 1039) to analyze the incidence of mortality and cardiovascular endpoints, hypertension and BP changes as function of UVNA changes. The prevalence of low/medium/high BW in the Outcome Cohort was 5.8/84.5/9.7%. Over 16.7 years (median), rates were 4.9%, 8.0% and 27.1% for mortality, CVD and hypertension, respectively, but were not associated with BW. Multivariable-adjusted hazard ratios were not significant for any endpoint in any of the BW, UVNA and UNAK strata. Adult body weight tracked with BW (P<0.0001). The partial r in the low BW group associating changes from baseline to follow-up in UVNA and systolic BP was 0.68 (P = 0.023), but not significant in other BW groups.

Conclusions:
This study did not substantiate its prior hypothesis, but showed tracking of adult with birth weight and suggest that low BW increases salt sensitivity.
ASSOCIATIONS BETWEEN ADHERENCE TO THE MEDITERRANEAN DIET AND 24-HOUR PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS
Authors: Kolak Ela , Radic Josipa , Vuckovic Marijana , Gelemanovic Andrea , Dogas Hana , Nenadic Dora Bucan , Radic Mislav 
Published: June 2023

Objective:
A Mediterranean diet (MeDi) is characterized by high consumption of plant-based food and fish, moderate consumption of red wine, and low intake of red and processed meat, and is associated with improvement in cardiometabolic risk factors. Arterial stiffness measured by pulse wave velocity (PWV) is considered a predictor of cardiovascular events, but the association between dietary intake according to MeDi and arterial stiffness is not yet clear. The aim of this study was to determine possible associations between MeDi adherence and PWV in patients with arterial hypertension (AH).

Design and method:
This study included 420 participants with AH of which 50.2% were women, with an overall median age of 63.5 years (IQR = 17.3). To assess 24-hour PWV parameter, a 24-hour ambulatory blood pressure monitor IEM Mobil-O-Graph based on the oscillometry was used. In order to determine adherence to the MeDi, a validated Mediterranean Diet Serving Score (MDSS) questionnaire was used. For every participant, data about comorbidities was collected from their medical records combined with their self reports.

Results:
Adherence to the MeDi defined as MDSS score >14 was found in 6.4% of participants. The mean value of 24-hour PWV was 9.08±1.88 m/s. Significant differences in PWV value were not found among high adherence, medium adherence and low adherence to MeDi. Positive predictors of 24-hour PWV were older age (beta = 0.128, p<0.001), presence of chronic kidney disease (beta = 0.312, p<0.001) and adherence to the legumes intake recommendation (beta = 0.169, p = 0.037), while the negative predictor was adherence to the dairy intake recommendation (beta = -0.174, p = 0.024).

Conclusions:
Exceptionally low adherence to the principles of the MeDi was noticed in hypertensive patients, with dairy and legumes suggested as predictors of 24-hour PWV. This suggests a need for structural nutritional intervention to increase adherence to the MeDi in order to decrease and reduce cardiovascular risk in this population of patients.
RELATIONSHIP BETWEEN BLOOD PRESSURE AND LDL-C CONTROL AND PATIENT-REPORTED OUTCOMES: A CROSS-SECTIONAL EPIDEMIOLOGICAL STUDY IN ROMANIA (SNAPSHOT-1)
Authors: Vinereanu Dragos , Vittos Oana , Ciobanu Andreea , Dolofan Bogdan , Trambitas Nicoleta , Johnson Neil , Tanasescu Rodica , Guja Cristian 
Published: June 2023

Objective:
To assess correlation between patient reported outcomes (PRO: socio-economic factors, depression level, and treatment adherence) and control of blood pressure (BP) and LDL-cholesterol (LDL-C).

Design and method:
This cross-sectional, observational, multicenter, epidemiological (SNAPSHOT-1) study included 2469 hypertensive patients with dyslipidemia, from outpatient clinics, recruited by cardiologists, diabetologists and general practitioners. Patients completed a three-part questionnaire including: (1) questions on socio-economic factors (education, marital status, working status, socio-professional category, incomes, and physical activity); (2) Patient Health Questionnaire (PHQ-9) (Depression scale); and (3) Hill-Bone Medication Adherence Scale (HBMAS) for hypertension and dyslipidemia (according to scoring guide, patients were considered as adherent if they answered “none of the time” or “some of the time” to specific questions). The correlations between PRO and control status and those between self-reported adherence and other PRO were assessed by logistic regression models (including variables with p-value<0.2 in univariate analyses on top of age, gender, and ethnicity).

Results:
Study population included 40.9% men, aged 65.0±10.0 years. Half of patients had depression symptoms (53.3%). The majority of patients self-reported being adherent to their hypertension (91.8%) and dyslipidemia (89.6%) treatments. Socio-economic factors are described in Table 1.
Patients with higher socio-professional category (managerial), without depression symptoms, and good adherence to treatment were more likely to have their BP controlled. Patients with good adherence to treatment were more likely to have their LDL-C controlled (Table 2).
Patients with higher socio-professional category, not married/not in relationship, physically active, and without depression symptoms were more likely to be adherent to antihypertensive treatment. Patients not married/not in relationship, physically active, and without depression symptoms were more likely to be adherent to lipid-lowering treatment. Higher education highly correlated with adherence to antihypertensive treatment (Table 3).

Conclusions:
Patient reported outcomes (PRO) correlate with BP and LDL-C control. Self-reported adherence to treatment also correlates with some socio-economic factors and with depression level. Thus, relevance of PRO assessment in routine clinical practice in patients with hypertension and dyslipidemia needs to be further evaluated.
D-DIMER AS AN ASSOCIATED FACTOR FOR LONG-TERM MORTALITY IN PATIENTS WITH ACUTE SEVERE HYPERTENSION
Authors: Kim Byung Sik , Shin Jeong-Hun , Shin Jinho 
Published: June 2023

Objective:
D-dimer, which serve as a marker of thrombotic events, was associated with poor outcome in various cardiovascular disease. However, there are no study on its prognostic implication in acute severe hypertension. This study aimed to investigate the association between D-dimer and long-term mortality in patients with acute severe hypertension visiting the emergency department.

Design and method:
This observational study included patients with acute severe hypertension who visited emergency department between 2016 and 2019. Acute severe hypertension was defined as systolic blood pressure > = 180 mmHg or diastolic blood pressure > = 100 mmHg. Among the 10219 patient, 4203 patients who performed assay for D-dimer were analyzed. Patients were categorized into tertiles according to D-dimer levels upon admission to the emergency department.

Results:
Among the 4203 patients with acute severe hypertension, 3.2% in the first (lowest) tertile, 17.7% in the second tertile, and 44.8% in the third (highest) tertile of D-dimer died up to 3-years. After adjusting for confounding variables, third tertile of D-dimer group (hazard ratio 8.105; 95% confidence interval, 5.799–11.327) and second tertile of D-dimer group (hazard ratio 3.234; 95% confidence interval, 2.298–4.550) showed significantly higher risk of 3-year all-cause mortality than first tertile of D-dimer group.

Conclusions:
D-dimer may be a useful marker for identifying high-risk group at risk of mortality in patients with acute severe hypertension visiting emergency department.
ARTERIAL HYPERTENSION IN RURAL AND NON-RURAL POPULATIONS OF A CITY IN THE NORTHERN ARGENTINE REPUBLIC IN THE YEAR 2022
Authors: Romano Jose René , Rajha Jorge Miguel 
Published: June 2023

Objective:
to evaluate the prevalence of arterial hypertension and characteristics of how, why and when they are consulted in rural and non-rural populations of north argentine.

Design and method:
The study was carried out in 4 towns in the province of Formosa, a province in the north of the Argentine Republic, located 512, 354, 162 and 103 km away from the capital city of that province and in a hospital in the capital. It was done in all the cases in public institutions and the patients used as controls were patients not derived from rural areas treated in the capital. During the year 2022. A survey was carried out and pressure taking with validated tensiometers and in the recommended conditions. The data They were analyzed by the STatistix program.

Results:
Of 1034 patients attended, a random sample of 20% of said population was taken and a similar sample in the city, it was observed in the rural sample a mean age of 48 years, 52% male, blood pressure (BP) systolic ( S) mean 145 and diastolic (D) 83, and with AHT 51.1% S and 39.3% D. 24% of the patients attended consulted for HBP. They presented HTA 180/110 or more: 10%. 3% were referred for presenting signs of target organ damage. Those from the city: average age 39 years, consulted for HTA 42%. The average BP S 141 D 85. Hypertensive patients in the consultation 43% S and 35% D. In rural areas 8.75% of autochthonous aboriginal race that increased over time with the number of cares (1 patient to 5 to 6 patients).

Conclusions:
The differences with patients who consult in the city of age to which they consult, the degree of control of hypertensive patients and the number of patients known to be hypertensive and consultation for control were demonstrated, therefore, it was possible to attend to special populations, in this Aboriginal case and measure variables in them. It is expected in the future to evaluate the utility at the population level of these services.
CLINICAL AND DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH LIPITENSION: RESULTS FROM THE LARGEST RETROSPECTIVE EMR STUDY FROM INDIA
Authors: Natarajan Vidhya , Dalal Jamshed , Chandra Praveen , Ponde Chandrashekhar , Hazra Prakash , Kumar Viveka , Bhalla Neeraj , Naqvi Mujtaba , Gaurav Kumar , Dhanaki Gauri , Rathod Rahul , Kotak Bhavesh 
Published: June 2023

Objective:
Common end-organ manifestations of hypertension and dyslipidemia predispose patients to develop cardiovascular diseases (CVD). The data on coexistent hypertension and dyslipidemia (lipitension) in India is scarce. In patients with lipitension CVD risk is amplified, therefore necessitating better understanding of their current clinical characteristics and treatment gaps.

Design and method:
This was an EMR based, retrospective, multicenter, cross sectional, database study to evaluate the demographic and clinical profile of adult patients with age more than 18 years having coexistent hypertension and dyslipidemia in India. Data of patients with Type 1 Diabetes Mellitus, Familial Hypercholesterolemia and pregnant females were excluded.

Results:
Data of 6722173 (6.7 million approx.) patients with age more than or equal to 18 years registered in EMR from January 2021 to December 2021 was extracted from the EMR database. Out of these patients, 38343 cases (0.57%) were found to have lipitension. Mean age was noted to be 54.71 years and 55.5% of them were males. The mean BMI of the patients was 28.3 kg/m2, and 76% of patients had an above normal BMI (>24.99). The mean SBP and DBP in mmHg were noted to be 139.98 and 85.47, respectively. Only 8% and 18.7% of patients had a normal SBP and normal DBP, respectively. The mean in mg/dl (% non-optimal control) of LDL, total cholesterol, triglycerides and VLDL was 124.2 (89.2), 195.1 (46.6), 176.8 (56.1) and 27.4 (40.7), respectively. The mean HDL was 46.69 mg/dl and optimal HDL of >60 mg/dl was noted in 11% of patients. Beta blockers (20.2%) and combination of anti-hypertensive with diuretics (14.5%) were most used for hypertension. Statins in combination with other medicines were used in 33.3% of patients and 41.7% were on statins alone.

Conclusions:
The findings suggests that control of lipitension in India is inadequate despite current therapy being offered, this puts patients at a higher risk for early-onset CVD. Hence, there is an urgent need to create awareness and optimize management of lipitension.
THE SUPERNOVA PHENOMENON IN SURVIVORS OF THE LENINGRAD SIEGE
Authors: Moguchaia Ekaterina , Usoltsev Dmitry , Boyarinova Maria , Alieva Asiyat , Vasilyeva Elena , Rotar Oxana , Konradi Alexandra , Shlyakhto Evgeny , Artomov Mykyta 
Published: June 2023

Objective:
The SUPERNOVA phenomenon as a protective phenotype is hypothesized to prevent vascular aging and therefore protect against adverse cardiovascular events. The aim of our study was to determine prevalence of SUPERNOVA in a unique cohort Survivors of the Leningrad Siege.

Design and method:
We assembled a cohort of 232 residents of besieged Leningrad aged 71-92 years. Anthropometry, blood pressure (BP) measurement, biochemical blood tests were performed. The arterial stiffness was assessed with SphygmoCor, through measurment of the pulse wave velocity (PWV). Based on the age-appropriate reference PWV values for subjects over 70 years old,we isolated the SUPERNOVA phenotype if the PWV value was less than the 10th percentile for this age group(PWV less or equal 7.9 m/s). Statistical analysis was performed with IBM SPSS Statistics 26.0.

Results:
28 (10,7%) Siege survivors- 7 men (25.9%) and 21 women (74.1%) had the SUPERNOVA phenomenon, others formed control group (204) which was comparable by age and gender. Due to the significant difference in body mass index (BMI) between groups comparative analysis of the phenotypic features was adjusted for BMI. Table1. Clinical and laboratory parameters comparision between SUPERNOVA and other vascular phenotypes

Conclusions:
Despite malnutrition in early stage of life and lifetime exposure to risk factors,10.7 % of Leningrad Siege survivors had supernormal vascular aging at advanced. Lower blood pressure and body mass index burden was observed as factors associated with supernormal vascular aging in the cohort of Siege survivors.
FRANCE DURING MAY MEASUREMENT MONTH: RESULTS OF HYPERTENSION SCREENING UNDER THE AUSPICES OF THE FRENCH SOCIETY OF HYPERTENSION (SFHTA)
Authors: Lopez-Sublet Marilucy , Pathak Atul , Bergot Tessa , Dinic Miriana , Malefou Mireille , Yara Antakly Hanon , Mourad Jean-Jacques , Renaudineau Eric , Boivin Jean Marc , Dauchy Edith , Sosner Philippe , Escande Michele , Lequeux Benoit , Boulestreau Romain , Duly-Bouhanick Beatrice 
Published: June 2023

Objective:
Launched by the International Society of Hypertension and supported by the World League Against Hypertension, May Measurement Month (MMM) is a worldwide campaign to screen for hypertension. The objective of this study is to identify, valorize, and publicize the data obtained in France and Monaco on the occasion of MMM 2022 under the auspices of the French Society of Hypertension (SFHTA).

Design and method:
The SFHTA proposed ‘an MMM protocol kit’ adapted in French and declared to the Committee for the Protection of Persons with the support of the French Society of Cardiology. A blood pressure monitor (Omron HEM-FL31/M3 Comfort) was sent to the centers that had requested it. 12 centers participated from June to October.

Results:
Are summarized in the table.
In this population of 1187 subjects, women were in the majority. Eight out of 10 screened subjects measured their BP at least once a year. 34% declared themselves to be hypertensive, and among the treated hypertensives, 56% reported being on monotherapy. 10% of the screened individuals are not vaccinated against COVID.

Conclusions:
The SFHTA, which is positively involved with European and International bodies to raise awareness of hypertension screening, has encouraged its members to participate collectively. Our MMM data collected remain limited about interpretation in public health and at the level of the French population. Nevertheless, the MMM approach could help alert to the public, health professionals, and government authorities to reduce the burden of hypertension.
Thanks to all the teams of each site who participated in this campaign.
TYPE 2 DIABETES AND CARDIORENAL SYNDROMES. A NATIONWIDE FRENCH HOSPITAL COHORT STUDY
Authors: Halimi Jean Michel , Maisons Valentin , Fauchier Laurent 
Published: June 2023

Objective:
Type 2 diabetes mellitus (T2DM) is a risk factor for cardiac and renal complications ; its effect on cardiorenal syndromes is unknown.

Design and method:
In a French nationwide cohort of 5,123,193 patients hospitalised in 2012 with at least 5 years of follow-up, we assessed the effect of T2DM on cardiorenal syndrome incidence and outcomes based on cardiorenal syndrome's subtype (cardiorenal, renocardiac, and simultaneous) using 1:1 propensity matching.

Results:
Among 4,605,236 patients without cardiorenal syndrome, 391 186 (8·5%) with T2DM were matched to 380,581 to patients without T2DM. During follow-up, cardiorenal syndrome occurred in 104,788 patients (simultaneous: 25,225 [24.0%]; cardiorenal: 51,745 [49.4%]; renocardiac 27,818 [26.5%]). T2DM doubled the risk of incident CRS (1.30% vs 0.65%/year; adjusted hazard ratio [HR] for any cardiorenal syndrome: 1.92, 95% confidence interval (95%CI): (1.88 to 1.96); renocardiac: 2.21 (2.13 to 2.30); cardiorenal: 1.86 (1.81 to 1.91); simultaneous: 1.73 (1.66 to 1.81).
Among the 26,396 patients with CRS at baseline, 11,355 (43.0%) had T2DM and were younger than non-diabetic patients (77.4±9.5 vs 82.3±10.0); 8,314 patients with T2DM were matched to 8,314 patients without. T2DM increased risk of end-stage kidney disease (adjusted HR: 1.39 (1.29 to 1.50)), myocardial infarction (HR: 1.37 (1.21 to 1.56)), cardiovascular death (HR: 1.16 (1.10 to 1.23)), heart failure (HR: (1.17 (1.12 to 1.21)), and all-cause death (HR: 1.09 (1.05 to 1.12)), but not ischaemic stroke.

Conclusions:
Patients with T2DM represent almost half of patients with cardiorenal syndromes and are younger than their non-diabetic counterparts. T2DM doubles risk of cardiorenal syndrome and increases risk of death, cardiovascular outcomes, and end-stage kidney disease but not ischaemic stroke after cardiorenal syndrome.