bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of acute exposure to Al2O3-NPs (α and γ) and white noise and their combination on Cochlea structure and function in Wistar Rat
Authors: Shahtaheri Seyed Jamaleddin , Goodarzi Zahra , karami esmaeil , Khavanin Ali , Khansari Mahmoud Ghazi , Kiani Mehrafarin , Rashidy-Pour Ali 
Published: January 2023

Abstract
Noise and combination-induced hearing loss is a common work-related disease among workers. The present research aimed to investigate the impact of independent and combined acute exposure to white noise plus Al2O3-NPs on changes in hearing and structural functions of the cochlea in rats. A total of 36 rats were randomly classified into six groups: Control, acute exposure to white noise, exposure to Al2O3-NPs (γ), exposure to noise plus Al2O3-NPs (γ ), exposure to Al2O3-NPs (α), and exposure to the combination of noise plus Al2O3-NPs (α). TTS and PTS were examined using DPOAE. Oxidative index (MDA, GSH-Px), gene expression (NOX3, TGF-ß, CYP1A1), protein expression (ß-Tubulin, Myosin VII), and histopathological changes were examined in the cochlea. The morphology of AL2O3-NPs was examined by TEM. The results of the DPOAE test, TTS in all groups, and the PTS in the groups exposed to noise, Al2O3-NPs (γ), and a combination of noise plus Al2O3-NPs increased significantly (p < 0.05). In exposure to white noise plus Al2O3-NPs, the MDA levels increased, the level of GSH-Px decreased, the expression percentage of ß-Tubulin and Myosin VII decreased, and the expression of NOX3, TGF-ß, and CYP1A1, (except for AL2O3-NPs (α) group) significantly increased (p < 0.05). Histopathological changes of the cochlea indicated damage in hair and ganglion cells which was higher in the combined exposures. The combined and independent exposure to white noise plus Al2O3-NPs damaged hair and ganglion cells for high-frequency perception, thereby affecting the function and structure of the cochlea and leading to TTS and PTS.
Is gambling like a virus?: A conceptual framework based on empirical data for the prevention of gambling addiction
Authors: Chóliz Mariano 
Published: January 2023

Abstract

Objective. The objective of this study is to present a conceptual framework for the prevention of gambling disorder and try to corroborate some of its postulates. The assumption of gambling as if it were acting like a virus may have important considerations in terms of preventing gambling disorder in society and, therefore, it could be a relevant public health issue.
Study Design. This research is a quasi-experimental investigation aimed to evaluate the effects of anti-COVID measures on the frequency of gambling and evolution of gambling disorder. The present study analyzed gambling patterns and the problems caused by gambling in 2,903 people, including those who were at-risk gamblers or had a gambling disorder. Results. In general terms, restrictive measures to combat COVID-19 worked to prevent the consolidation of gambling habits and the appearance of gambling disorder, but they did not seem to be sufficient for people who already had this disorder. The most affected games were those that took place in public places (gambling halls, bars, etc.), with online gambling being affected to a much lesser degree.
Conclusions. The findings of this work support the hypothesis that, just as the SAR-CoV-2 virus is responsible for the global pandemic of COVID-19, which can only be stopped with vaccines and social distancing, in the case of gambling, the absence of an effective vaccine for "gambling virus" can lead to an epidemic of gambling disorders in societies, if the environmental conditions that are favorable for the spread of such virus are not modified.
Nonlinear modal analysis of multi-walled nanotube oscillations using nonlocal anisotropic elastic shell model
Authors: Avramov Konstantin , Grebennik I. 
Published: January 2023

Abstract
System of nonlinear partial differential equations, which describes the multi-walled carbon nanotube nonlinear oscillations, is derived. The Sanders-Koiter nonlinear shell theory and the nonlocal anisotropic Hooke’s law are used in this model. Three kinds of nonlinearities are accounted. First of all, the van der Waals forces are nonlinear functions of the radial displacements. Secondly, the nanotube walls displacements have moderate values, which are described by the geometrically nonlinear shell theory. Thirdly, as the stress resultants are the nonlinear functions of the displacements, the additional nonlinear terms in the equations of motions are obtained. These terms are derived from the natural boundary conditions, which are used in the weighted residual method. The finite degrees of freedom nonlinear dynamical system is derived to describe the oscillations of nanostructure. The Shaw-Pierre nonlinear normal modes in the form of the multi-mode invariant manifolds are used to describe the free nonlinear oscillations, as the dynamical systems contains the internal resonances 1:1. The motions on the invariant manifolds are described by two degrees of freedom nonlinear dynamical systems, which are analyzed by the multiple scales method. The backbone curves of the nonlinear modes are analyzed. As follows from the results of the numerical simulations, the eigenmode of low eigenfrequency has commensurable longitudinal, transversal and circumference displacements. The nonlinear parts of the van der Waals forces harden essentially the backbone curve of the oscillations close to this eigenmode.
Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol
Authors: Boonsuth Ratthaporn , Battiston Marco , Grussu Francesco , Samlidou Christina , Calvi Alberto , Samson Rebecca S. , Wheeler-Kingshott Claudia A. M. Gandini , Yiannakas Marios C. 
Published: January 2023

Abstract
Magnetic resonance neurography (MRN) has been used successfully over the years to investigate the peripheral nervous system (PNS) because it allows early detection and precise localisation of neural tissue damage. However, studies demonstrating the feasibility of combining MRN with multi-parametric quantitative magnetic resonance imaging (qMRI) methods, which provide more specific information related to nerve tissue composition and microstructural organisation, are lacking. The translation of emerging qMRI methods previously validated in the central nervous system to the PNS offers real potential to characterise in patients in vivo the underlying pathophysiological mechanisms involved in a plethora of conditions of the PNS. The aim of this study was to assess the feasibility of combining MRN with qMRI to measure diffusion, magnetisation transfer and relaxation properties of the healthy sciatic nerve in vivo. The reproducibility of the multi-parametric qMRI protocol as well as normative qMRI measures in the healthy sciatic nerve are reported. The findings presented herein pave the way to the practical implementation of joint MRN-qMRI in future studies of pathological conditions affecting the PNS.
Safe radiofrequency ablation for low platelet count patients with a novel platelet count raising drug (lusutrombopag): Prospective Observational Study
Authors: Yoshida Hideo , Ohki Takamasa , Kanezaki Mineo , Teratani Takuma , Sato Shinpei , Obi Shuntaro , Sato Takahisa , Akamatsu Masatoshi , Uchino Koji , Taniguchi Hiroyoshi 
Published: January 2023

Abstract
Background
Platelet (PLT) transfusion was the most practical way to increase patients’ PLT counts before invasive hepatic procedures such as radiofrequency ablation (RFA) for liver cancer. A novel drug that raises the PLT count by acting on the thrombopoietin receptor has recently become available.
Methods
Lusutrombopag 3mg was administered daily for 7 days to patients who underwent RFA for liver tumors with low PLT counts (< 50,000 PLT µL− 1). We collected demographic data concerning the patients’ liver function and PLT counts.
Results
Lusutrombopag was administered to 91 patients, with a median age of 71 years (range 51–86). Forty-two patients had hepatitis C, 12 had hepatitis B, 21 had alcoholic liver disease, 11 had nonalcoholic steatohepatitis, and five had other diseases. The median Child-Pugh score was 7 (range 5–11). Thirty-seven patients had stage I tumors, 41 had Stage II, 12 had stage III, and one had stage IV. PLT count was elevated from 4.4x104 ± 1.4x104 to 8.6x104 ± 2.5x104 PLT µL− 1. Lusutrombopag administration prevented PLT transfusions in 84/91 patients (92%). No patient had bleeding complications after RFA. One had portal thrombosis after lusutrombopag administration. Patients who achieved PLT counts of > 50,000 PLT µL− 1 had higher PLT counts before lusutrombopag administration. The degree of splenomegaly did not affect the rate of PLT count elevation. There was no specific adverse effect by administrating lusutrombopag for patients with PLT counts of around 50,000 µL− 1 but > 50,000 µL− 1.
Conclusions
Lusutrombopag administration before RFA was safe and effective for hepatocellular carcinoma patients with low PLT counts.
Traffic data security sharing scheme based on blockchain and traceable ring signature for VANETs
Authors: zhang xiaohong , Lai Jiaming , Moshayedi Ata Jahangir 
Published: January 2023

Abstract
Vehicular ad hoc networks (VANETs) is the hotspot research field of wireless mobile ad hoc network, it provides a new opportunity to create a safe and efficient transportation environment. However, as an open network where information has to interact frequently, it is difficult to ensure the security of data transmitted in VANETs and protect the privacy of drivers. Many existing information sharing schemes use complex encryption algorithms to enable secure traffic data sharing. Nevertheless, these schemes are not suitable for VANETs because of their high computational overhead and lack of corresponding tracking mechanisms for malicious vehicles. Therefore, a traffic data security sharing scheme is designed that combines blockchain technology and traceable ring signature algorithms to secure the transmitted messages. The traceable ring signature algorithm is formulated in combination with bilinear pairing, enabling conditional privacy protection instead of traditional ring signature. To improve the efficiency of VANETs, this scheme introduces edge computing technology to reduce the computational burden of Road Side Units (RSUs) by offloading most of the computational tasks to the servers via edge nodes. In addition, we use smart contract to track malicious vehicles.
Security analysis and performance comparison show that our scheme is more efficient and secure for drivers than other existing related schemes.
Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway
Authors: Li Xingshu , Oh Jae Sang , Lee Yoonji , Lee Eun Chae , Yang Mengyao , Kwon Nahyun , Ha Tae Won , Hong Dong-Yong , Song Yena , Kim Hyun Kyu , Song Byung Hoo , Choi Sun , Yoon Juyoung , Lee Man Ryul 
Published: January 2023

Abstract
Background
Malignant glioma is among the most lethal and frequently occurring brain tumors, and the average survival period is 15 months. Existing chemotherapy has low tolerance and low blood-brain barrier (BBB) permeability; therefore, the required drug dose cannot be accurately delivered to the tumor site, resulting in an insufficient drug effect.
Methods
Herein, we demonstrate a precision photodynamic tumor therapy using a photosensitizer (ZnPcS) capable of binding to albumin in situ, which can increase the permeability of the BBB and accurately target glioma. Albumin-binding ZnPcS was designed to pass through the BBB and bind to secreted protein acidic and rich in cysteine (SPARC), which is abundant in the glioma plasma membrane.
Results
When the upper part of a mouse brain was irradiated using a laser (0.2 W cm− 2) after transplantation of glioma and injection of ZnPcS, tumor growth was inhibited by approximately 83.6%, and the 50% survival rate of the treatment group increased by 14 days compared to the control group. In glioma with knockout SPARC, the amount of ZnPcS entering the glioma was reduced by 63.1%, indicating that it can target glioma through the SPARC pathway.
Conclusions
This study showed that using albumin-binding photosensitizers is promising for the treatment of malignant gliomas.
Supporting US Healthcare Providers for Successful Vaccine Communication
Authors: Pierz Amanda J , Rauh Lauren , Masoud Dima , Cruz Alanna Kate , Palmedo P. Chris , Ratzan Scott C , Parker Ruth 
Published: January 2023

Abstract
Background
While many healthcare providers (HCPs) have navigated patients’ vaccine concerns and questions prior to the rollout of the COVID-19 vaccines, sentiments surrounding the COVID-19 vaccines have presented new and distinct challenges.
Objective
To understand the provider experience of counseling patients about COVID19 vaccinations, aspects of the pandemic environment that impacted vaccine trust and communication strategies providers found supportive of patient vaccine education.
Methods
7 focus groups of healthcare providers were conducted and recorded during December 2021 and January 2022, at the height of the Omicron wave in the United States. Recordings were transcribed, and iterative coding and analysis was applied.
Results
44 focus group participants representing 24 US states with the majority (80%) fully vaccinated at the time of data collection. Most participants were doctors (34%) or physician’s assistants and nurse practitioners (34%). The impact of COVID-19 misinformation on patient-provider communication at both intrapersonal and interpersonal levels as well as barriers and facilitators to patient vaccine uptake are reported; messengers and messages that promote or combat misinformation are described. Providers expressed frustration in addressing vaccine hesitancy among patients who remained unvaccinated. Many valued resources providing up-to-date and evidence-based information as COVID-19 guidelines continued to change. Additionally, providers indicated that patient-facing materials were the most helpful in navigating a changing information environment and underscored that these were not frequently available.
Conclusions
To strengthen provider vaccine communication and promote vaccine uptake, a supportive communication infrastructure must be sustained around the patient-provider dyad. The findings provide recommendations to sustain an environment that supports provider-patient communication at the community, organizational and policy levels. There is a need for a unified multisectoral response to reinforce the recommendations in patient settings.
Co-development of Vulnerability and Risk Assessment Framework and Methodology for Nepal
Authors: Regmi Bimal Raj , Sapkota Regan , Paudya Apar , Gautam Dilip Kumar , Thapa Rajan , Joshi Rojy , Shah Smriti , Mishra Bhogendra , GC Gita 
Published: January 2023

Abstract
Conducting a Vulnerability and Risk Assessment is a critical step in adaptation planning and implementation. This research paper has assessed how the co-developed approach helped the Government of Nepal and stakeholders in Nepal to agree on and operationalize the Vulnerability and Risk Assessment framework and what works best for the country's context. The output of the vulnerability and risk assessment in Nepal presents a compilation of impacts, vulnerabilities, and risks and a description of their context, root causes, trends, and assumptions made. However, there were some challenges faced in analysing the vulnerability and risks based on the indicators. There was a lack of a multi-year, complete, and unform database, the analysis thus depended on the data available. Also, there were difficulties in developing scenarios of hazards due to unclarity on climate change attribution. The lessons from this paper will be important for designing a more practical and country-driven VRA framework and methodology for Nepal and other developing countries.
PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes
Authors: Antal Dóra , Pór Ágnes , Kovács Ilona , Dull Katalin , Póliska Szilárd , Ujlaki Gyula , Demény Máté Ágoston , Szöllősi Attila Gábor , Kiss Borbála , Szegedi Andrea , Bai Péter , Szántó Magdolna 
Published: January 2023

Abstract
Poly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity and they were first described as DNA repair factors. However, research in past decades implicated PARPs in biological functions as diverse as the regulation of cellular energetics, lipid homeostasis, cell death and inflammation. PARP activation was described in Th2-mediated inflammatory processes, but studies focused on the role of PARP1, while we have little information on PARP2 in inflammatory regulation. In this study we assessed the role of PARP2 in a Th17-mediated inflammatory skin condition, psoriasis. We found that PARP2 mRNA expression is increased in human psoriatic lesions. Therefore, we studied the functional consequence of decreased PARP2 expression in murine and cellular human models of psoriasis. We observed that the deletion of PARP2 attenuated the imiquimod-induced psoriasis-like dermatitis in mice. Silencing of PARP2 in human keratinocytes prevented their hyperproliferation, maintained their terminal differentiation and reduced their production of inflammatory mediators after treatment with psoriasis-mimicking cytokines IL17A and TNFα. Underlying these observations we found that aromatase was induced in the epidermis of PARP2 knock-out mice and in PARP2-deficient human keratinocytes, and the resulting higher estradiol production suppressed NF-κB activation, and hence, inflammation in keratinocytes. Steroidogenic alterations have previously been described in psoriasis, and we extend these observations by showing that aromatase expression is reduced in psoriatic lesions. Collectively, our data identify PARP2 as a modulator of estrogen biosynthesis by epidermal keratinocytes and hence inflammation in the skin, as well as highlight a potential targetable pathway in psoriasis.
Effect of matrix particle size on densification behavior, microstructure and mechanical properties of an Al/FMG/SiC hybrid composite
Authors: Rezaei M. R. , Albooyeh A. R. , Golafshani F. Ghafari 
Published: January 2023

Abstract
Hybrid aluminum matrix composites reinforced with Fe-based metallic glass (FMG) and SiC particles were prepared using the spark plasma sintering (SPS) process, and the effect of matrix particle size on density, microstructure, and mechanical properties was investigated. The porosity content of the composites increased with increasing matrix particle size. Both reinforcing particles showed a more homogenous distribution in the matrix when smaller particles were used for the matrix of the composites. The phase properties and the stored dislocation density were not meaningfully affected by changing matrix particle size. The yield compressive strength and ductility of the composites decreased significantly with increasing particle size, so that the yield strength of the hybrid composite with a matrix particle size of 20 μm was about 80% higher than that of a similar composite with a matrix particle size of 63 μm.
Amorphous Silicon particles/Polyaniline composites for hybrid photovoltaic solar cell: An experimental feasibility study
Authors: Charekhah Reza , Farzi Gholamali , Alehdaghi hassan 
Published: January 2023

Abstract
Hybrid heterojunctions of Polyaniline/Amorphous Silicon (PAni / a-Si:H) were synthesized in order to fabricate the active layer of the polymeric solar cells. For this purpose, amorphous silicon nanoparticles were blended with polyaniline which was synthesized through oxidative polymerization. Then the resultant nanocomposite was applied on FTO in the FTO/ZnO/PANI:a-Si/Ag structure using the spin coating method. The effect of amorphous silicon content on light-harvesting efficiency was studied using the UV-VIS spectroscopy data, electrochemical impedance spectroscopy (EIS), and the incident photon to current efficiency (IPCE) analysis. PAni / a-Si:H nanocomposites were characterized structurally and morphologically using Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and X-ray diffraction (XRD) analysis. Current-Voltage measurements of the photovoltaic cells based on PAni / a-Si:H nanocomposites showed that by increasing the amount of a-Si:H in the active layer by 40 Wt%, the efficiency of the cell increases up to 2k times compared to the cell made with pure PAni. Also, in general, cell efficiencies increased slightly with decreasing the size of amorphous silicon nanoparticles at a constant PAni / a-Si:H weight ratio. The impact of a-Si:H weight percent is more significant in the case of smaller silicon particles.
Estimating marginal abatement cost for methane emission from agriculture: empirical evidence for paddy cultivation in India
Authors: Some Shreya , Roy Joyashree , Ghose Arpita , Sharma Pawan Kumar 
Published: January 2023

Abstract
Implementing mitigation options through adoption of alternative practices entail cost. Methane emission from paddy/rice cultivation accounts for approximately one-fifth of India’s total methane emission. It occurs mainly due to flooded paddy cultivation practices which accounts for 30% of land under paddy cultivation in India. Several practices are available for reducing methane emission from paddy cultivation in India. The literature shows the highest mitigation potential is offered by irrigated multiple aeration method (IR_MA or AWD), 52.8-61.4% compared to baseline practice irrigated continuously flooded. Direct seeded rice (DSR) offers 30-50% reduction compared to the baseline transplanted rice. In this paper, we apply econometric model to estimate the cost of adopting mitigation options using marginal abatement cost (MAC) approach. Findings clearly show initial reductions in emission can be achieved with relatively lower marginal cost. However, consistent with theoretical literature MAC increases at an increasing rate with additional unit of emission reduction. We also find that MAC varies with the scale of operation viz, size of land cultivated under the baseline practice. Higher the scale of operation higher is the MAC. Also, given the scale of operation, MAC varies with the concentration of emission i.e., emission from a given amount of land. Higher the concentration of emission, higher is the MAC. Estimates show if MACs are used to evaluate emission tax level, similar to carbon price, then it will inflict a high additional cost burden of 5-350% of their current cost of production on the farmers unless compensated through policy mechanism.
Reduction by Air Purifier of Particulate Concentration During Orthodontic Procedures: a Pilot Study
Authors: Martín-Quintero Inmaculada , Cervera-Sabater Alberto , Brinkmann Jorge Cortés-Bretón , Aragoneses-Lamas Juan Manuel , Flores-Fraile Javier , Santos-Marino Juan 
Published: January 2023

Abstract

Background: The SARS-CoV-2 pandemic has raised awareness of the importance of air quality. This pilot study arose from the need to reduce the concentration of particulate matter in the dental office during orthodontic procedures. To evaluate the efficacy of using an air purifier during orthodontic care in the dental office to reduce the concentration of ambient particulate matter.
Results:Significant reductions in particle numbers were obtained for all particle sizes except the largest particles counted (10um) through use of the air filter. A marked association between higher humidity levels and higher particle counts was also observed.
Conclusions: Using an air purifier during dental care achieves a significant reduction in the concentration of ambient particles in the dental office. There is a correlation between higher relative humidity and higher particle concentration. The probability of obtaining a maximum particulate concentration level of 0.3um and 0.5um is 1000 times lower when using an air purifier.