bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Fracture After Bilateral Oophorectomy
Authors: Hueg Trine K , Hickey Martha , Beck Astrid L , Wilson Louise F , Uldbjerg Cecilie S , Priskorn Lærke , Abildgaard Julie , Lim Youn‐Hee , Bräuner Elvira V 
Published: May 2023

ABSTRACTFragility fractures, resulting from low‐energy trauma, occur in approximately 1 in 10 Danish women aged 50 years or older. Bilateral oophorectomy (surgical removal of both ovaries) may increase the risk of fragility fractures due to loss of ovarian sex steroids, particularly estrogen. We investigated the association between bilateral oophorectomy and risk of fragility fracture and whether this was conditional on age at time of bilateral oophorectomy, hormone therapy (HT) use, hysterectomy, physical activity level, body mass index (BMI), or smoking. We performed a cohort study of 25,853 female nurses (≥45 years) participating in the Danish Nurse Cohort. Nurses were followed from age 50 years or entry into the cohort, whichever came last, until date of first fragility fracture, death, emigration, or end of follow‐up on December 31, 2018, whichever came first. Cox regression models with age as the underlying time scale were used to estimate the association between time‐varying bilateral oophorectomy (all ages, <51/≥51 years) and incident fragility fracture (any and site‐specific [forearm, hip, spine, and other]). Exposure and outcome were ascertained from nationwide patient registries. During 491,626 person‐years of follow‐up, 6600 nurses (25.5%) with incident fragility fractures were identified, and 1938 (7.5%) nurses had a bilateral oophorectomy. The frequency of fragility fractures was 24.1% in nurses who were <51 years at time of bilateral oophorectomy and 18.1% in nurses who were ≥51 years. No statistically significant associations were observed between bilateral oophorectomy at any age and fragility fractures at any site. Neither HT use, hysterectomy, physical activity level, BMI, nor smoking altered the results. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling
Authors: Xie Yongheng , Bao Zhiteng , Wang Zhenmin , Du Danfeng , Chen Gaoyang , Liu Chungeng , Wang Hongyu , Feng Naibo , Xiao Xiao , Wang Song , Zhang Xin , Zhu Yong , Yuan Zhengbin , Long Houqing , Yang Dazhi , Peng Songlin 
Published: May 2023

ABSTRACTDysregulation of bone homeostasis is closely related to the pathogenesis of osteoporosis. Suppressing bone resorption by osteoclasts to attenuate bone loss has been widely investigated, but far less effort has been poured toward promoting bone formation by osteoblasts. Here, we aimed to explore magnesium ascorbyl phosphate (MAP), a hydrophilic and stable ascorbic acid derivative, as a potential treatment option for bone loss disorder by boosting osteoblastogenesis and bone formation. We found that MAP could promote the proliferation and osteoblastic differentiation of human skeletal stem and progenitor cells (SSPCs) in vitro. Moreover, MAP supplementation by gavage could alleviate bone loss and accelerate bone defect healing through promoting bone formation. Mechanistically, we identified calcium/calmodulin‐dependent serine/threonine kinase IIα (CaMKIIα) as the target of MAP, which was found to be directly bound and activated by MAP, then with a concomitant activation in the phosphorylation of ERK1/2 (extracellular regulated kinase 1/2) and CREB (cAMP‐response element binding protein) as well as an elevation of C‐FOS expression. Further, blocking CaMKII signaling notably abolished these effects of MAP on SSPCs and bone remodeling. Taken together, our data indicated that MAP played an important role in enhancing bone formation through the activation of CaMKII/ERK1/2/CREB/C‐FOS signaling pathway and may be used as a novel therapeutic option for bone loss disorders such as osteoporosis. © 2023 American Society for Bone and Mineral Research (ASBMR).
Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis‐sulfonamide Schiff base compounds
Authors: Aydin Hasan , Akocak Süleyman , Lolak Nebih , Yumrutaş Önder , Uslu Uğur , Bozgeyik Ibrahim , Üçkardeş Fatih , Günal Selami , Ceylan Onur 
Published: May 2023

AbstractSchiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis‐sulfonamide Schiff base derivatives that were re‐synthesized by us. For this aim, 16 compounds were re‐synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2, A1B4, A4B2, A4B3, and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis‐substituted compounds might be used as biologically potent pharmacophores against different types of diseases.
A tight bound for independent domination of cubic graphs without 4‐cycles
Authors: Cho Eun‐Kyung , Choi Ilkyoo , Kwon Hyemin , Park Boram 
Published: May 2023

AbstractGiven a graph , a dominating set of is a set of vertices such that each vertex not in has a neighbor in . Let denote the minimum size of a dominating set of . The independent domination number of , denoted , is the minimum size of a dominating set of that is also independent. We prove that if is a cubic graph without 4‐cycles, then , and the bound is tight. This result improves upon two results from two papers by Abrishami and Henning. Our result also implies that every cubic graph without 4‐cycles satisfies , which supports a question asked by O and West.
Assessing the impact of hospital mergers and acquisitions on safety culture with proactive risk assessments
Authors: Folcarelli Patricia , Hoffman Jock , Janes Margaret , MacCready Jennifer Clair , Roberts Annette , Boulanger Jason , DeMayo Melissa , Sanchez Jennifer Vuu , Szum Bessie Manley 
Published: May 2023

AbstractHospitals seeking to understand patient safety strengths and vulnerabilities in the context of mergers/acquisitions benefit more from a third‐party perspective than from a limited internal process. A well‐structured and highly‐inclusive risk assessment—involving a broad cross‐section of interviews—can be key to a successful transition of optimal health care safety during organizational changes.
The impact of environmental technology innovation and energy credit rebate on carbon emissions: A comparative analysis
Authors: Zakari Abdulrasheed , Khan Irfan , Alvarado Rafael 
Published: May 2023

AbstractThis study investigates the impact of environmental‐technological innovation and energy credit rebates on carbon reductions in Australia and its global comparison. We applied a system generalized method of moment (S‐GMM) on a dataset of 11 years (from 2008 to 2019) for Australia and 23 top green scheme economies. The main findings suggested that Australia's environmental innovation and energy credit rebates are associated with carbon reduction. Similarly, we found that environmental innovation is associated with carbon reduction in the 23 top green schemes economies, but energy credit rebate increases carbon emissions. This is due to the weak green financial system in the 23 top green schemes economies. We robust our findings, and the result confirmed a robust alternative model. These findings offer numerous essential policies for the government and stakeholders in the energy and environmental sectors. More specifically, it recommends more investment in environmental innovation and an overhaul of the green financial market.
Selecting a high‐dose antibiotic‐laden cement knee spacer
Authors: Hollyer Ian , Ivanov David , Kappagoda Shanthi , Lowenberg David W. , Goodman Stuart B. , Amanatullah Derek F. 
Published: May 2023

AbstractProsthetic joint infection [PJI] after total knee arthroplasty (TKA) remains a common and challenging problem for joint replacement surgeons and patients. Once the diagnosis of PJI has been made, patient goals and characteristics as well as the infection timeline dictate treatment. Most commonly, this involves a two‐stage procedure with the removal of all implants, debridement, and placement of a static or dynamic antibiotic spacer. Static spacers are commonly indicated for older, less healthy patients that would benefit from soft tissue rest after initial debridement. Mobile spacers are typically used in younger, healthier patients to improve quality of life and reduce soft‐tissue contractures during antibiotic spacer treatment. Spacers are highly customizable with regard to antibiotic choice, cement variety, and spacer design, each with reported advantages, drawbacks, and indications that will be covered in this article. While no spacer is superior to any other, the modern arthroplasty surgeon must be familiar with the available modalities to optimize treatment for each patient. Here we propose a treatment algorithm to assist surgeons in deciding on treatment for PJI after TKA.
The Application Value of Contrast‐Enhanced Ultrasonography in Assessing the Efficacy of Ultrasound‐Guided Lauromacrogol Injections in Cesarean Scar Pregnancies
Authors: Wu Dao‐Ming , Zhu Lin , Lin Tan , Chen Sheng , Wu Song‐Song , Lin Ning 
Published: May 2023

ObjectiveTo investigate the application value of contrast‐enhanced ultrasonography (CEUS) in ultrasound‐guided lauromacrogol injections in patients with cesarean scar pregnancies (CSP).MethodsA total of 31 patients diagnosed with CSP, who underwent an ultrasound‐guided lauromacrogol injection + curettage in our hospital between February 2019 and December 2020 and had a complete recovery confirmed by a postoperative ultrasound review and serum β‐human chorionic gonadotropin (β‐hCG) assay, were enrolled as the study subjects. According to the volume of intraoperative blood loss and the duration of postoperative vaginal bleeding, the patients were divided into two groups, with 19 in the significantly effective group (Group A) and 12 in the effective group (Group B). The recorded clinical data, including age, duration of amenorrhea, number of pregnancies, number of deliveries, time since last cesarean delivery, number of cesarean deliveries, and preoperative serum β‐hCG levels, were retrospectively analyzed. The morphological indicators in CEUS before the lauromacrogol injection, as well as immediately and 12–24 hours after the injection, were compared between the groups.ResultsIn Group A, the post‐injection CEUS showed no enhancement, single strip enhancement, and sparse punctate enhancement, while in Group B, it showed a more irregular ring and local patch enhancement. In addition, the number of cases where the CEUS showed no enhancement 12–24 hours after the injection was more than that of the immediate CEUS after the injection. In Group A, four (21.1%) cases showed a single strip‐like blood flow on the immediate postoperative CEUS, four (21.1%) cases showed a sparsely dotted blood flow on the immediate postoperative CEUS, and three cases turned into no enhancement 12–24 hours after the injection. A total of four cases in Group B showed that the contrast enhancement range 12–24 hours after the injection was reduced compared with that of the immediate contrast after the injection.ConclusionContrast‐enhanced ultrasonography can guide the location selection of the lauromacrogol injection in patients with CSP, and its postoperative morphological indicators can adequately predict the therapeutic effect after curettage and guide clinical management.
Effects of tillage practice on fungal and actinobacterial cellulolytic community with different humified particle‐size fractions in a double‐cropping paddy field
Authors: Tang Haiming , Shi Lihong , Wen Li , Cheng Kaikai , Li Chao , Li Weiyan , Xiao Xiaoping 
Published: May 2023

AbstractSoil cellulose plays a vital role in keeping or increasing carbon (C) cycling and fertility of rice fields. There is a close relation between soil fulvic acid (FA), humin (HM) fractions, and GH48, cbhI genes. However, the effects of different tillage practices on soil humus C content composition, GH48, and cbhI genes abundances in different soil particle‐size fractions of double‐cropping rice fields still need to be further investigated. Therefore, the impacts of different short‐term tillage practices on soil GH48 and cbhI genes abundances in double‐cropping rice fields were conducted. This experiment set up different tillage practices: rotary tillage with crop straw removed as a control (RTO), conventional tillage with crop straw in put (CT), rotary tillage with crop straw in put (RT), and no‐tillage with crop straw retain (NT). The result indicated that the distribution of soil humus, and GH48, cbhI genes abundances were significantly enhanced under combined applied with tillage and crop straw incorporation conditions. Soil FA, HM, and humic acid (HA) C content in 2000–50 μm and >2000 μm fractions with RTO treatment were significantly lower than that of CT, RT, and NT treatments. This result showed that oalkyl and alkyl of HA and FA in 2000–200, 200–50, 50–2, and 2–0.1 μm fractions with CT, RT, NT, and RTO treatments were lower than that of >2000 μm fraction. There was lower ARO% and more AL% of FA and HA in these fractions under the same tillage condition. The result showed that GH48 and cbhI genes abundances in these fractions with CT, RT, and NT treatments were significantly higher than that of RTO treatment. There had significantly positively correlated with GH48, cbhI genes abundances, and soil HA, FA, HM C contents, o‐alkyl C, and AL% of FA. Therefore, it was positively practiced for increasing GH48 and cbhI genes abundances in the double‐cropping rice fields by applying with tillage and crop straw incorporation.
Stakeholder perspectives on data sharing from pragmatic clinical trials: Unanticipated challenges for meeting emerging requirements
Authors: Morain Stephanie R. , Bollinger Juli , Weinfurt Kevin , Sugarman Jeremy 
Published: May 2023

AbstractIntroductionNumerous arguments have been advanced for broadly sharing de‐identified, participant‐level clinical trial data. However, data sharing in pragmatic clinical trials (PCTs) presents ethical challenges. While prior scholarship has described aspects of PCTs that raise distinct considerations for data sharing, there have been no reports of the experiences of those at the leading edge of data‐sharing efforts for PCTs, including how these particular challenges have been navigated. To address this gap, we conducted interviews with key stakeholders, with a focus on the ethical issues presented by sharing data from PCTs.MethodsWe recruited respondents using purposive sampling to reflect the range of stakeholder groups affected by efforts to expand PCT data sharing. Through semi‐structured interviews, we explored respondents' experiences and perceptions about sharing de‐identified, individual‐level data from PCTs. An integrated approach was used to identify and describe key themes.ResultsWe conducted 40 interviews between April and September 2022. Five overarching themes emerged through analysis: (1) challenges in sharing data collected under a waiver or alteration of consent; (2) conflicting views regarding PCT patient‐subject preferences for data sharing; (3) identification of respect‐promoting practices beyond consent; (4) concerns about elevated risks or burdens from sharing PCT data; and (5) diverse views about the likely benefits resulting from sharing PCT data.ConclusionOur data indicate unresolved tensions in how to fulfill the expectation to broadly share de‐identified, individual‐level data from PCTs, and suggest that those promulgating and implementing data‐sharing policies must be sensitive to PCT‐specific considerations. Future work could inform efforts to tailor data‐sharing policy and practice to reflect the challenges presented by PCTs, including sharing experiences from trials that have successfully navigated these tensions.
The influence of local wear and contact roughness on mixed lubrication of marine stern bearing with misaligned shaft
Authors: Zhao Zeyu , Huang Qianwen , Sheng Minghui 
Published: May 2023

AbstractThe marine stern bearing provides supporting force by lubricating film to minimise the contact friction with the propeller shaft. A model considers local wear and asperity contact is proposed to investigate the mixed lubrication of bearing with misalignment. The finite difference method and over‐relaxation iteration method are employed to solve the average Reynolds equation. The lubrication behaviour includes hydrodynamic pressure, film thickness, contact force and friction coefficient were calculated. The influence of sliding speed, local wear, contact roughness, misalignment angle, elastic deformation and eccentricity ratio is discussed in detail. The critical speed from mixed lubrication to fluid lubrication is obtained by employing the Stribeck curve. Moreover, the dimensionless average hydrodynamic pressure, film thickness and the peak value of contact force are compared.
Light and energy‐based therapeutics for genitourinary applications: Consensus on protocols and best practices
Authors: Alexiades Macrene R. , Iglesias Cheryl , Sokol Eric , Gaspar Adrian , Tadir Yona 
Published: May 2023

AbstractBackgroundLasers and energy‐based technologies have been developed for genitourinary applications over the past several decades.AimsThis consensus article aims to categorize the published articles and clinical trial data that culminated in protocol development of technology for genitourinary applications, and to develop consistent parameters in future clinical trials.Materials and MethodsThe published articles and clinical trials data on lasers and energy‐based devices applied to genitourinary conditions were categorized according to device and condition and consensus developed on protocols and parameters.ResultsThe devices in genitourinary applications were classified as fractional lasers, radiofrequency and high‐intensity focused electromagnetic field therapy. The consensus of the protocols and parameters based upon the published clinical trials of their application to the vaginal and urologic conditions associated with genitourinary syndrome of menopause was developed and organized according to device and condition.DiscussionThe status of FDA clearances and future pathways are discussed.ConclusionsThis consensus article categorizes and presents the protocols and practices for the main classes of lasers and energy‐based devices for genitourinary applications in future clinical trials.
Efficacy and safety of fractional 1064‐nm picosecond laser for atrophic traumatic and surgical scars: A randomized, single‐blinded, split‐scar‐controlled study
Authors: Disphanurat Wareeporn , Charutanan Nipathorn , Sitthiwatthanawong Pradtana , Suthiwartnarueput Worapop 
Published: May 2023

AbstractObjectiveA fractional 1064‐nm picosecond laser is an efficient and safe treatment for atrophic acne scars. However, evidence of using a picosecond laser for atrophic posttraumatic and surgical scar therapy is lacking. This study aimed to evaluate the efficacy and safety of using a 1064‐nm picosecond laser with a microlens array (MLA) for the treatment of atrophic posttraumatic and surgical scars.MethodsThis was a prospective, intraindividual, single‐blinded, randomized split‐lesion‐controlled trial. Twenty‐five subjects with atrophic traumatic or surgical scars that existed for more than 1 year were enrolled. All atrophic scars were divided at the midline into two halves and randomly assigned to a treatment or control side. The treatment group was treated with a 1064‐nm picosecond laser with an MLA handpiece (spot size: 6–8 mm, fluence: 1.0–1.2 J/cm2, repetition rate: 5 Hz, three passes) for 3 monthly sessions. The scar volumes were objectively measured using a three‐dimensional (3D) photograph at baseline, 1 month after the first and second treatments, and 3 and 6 months after the final treatment. Subjective assessments were conducted by a blinded dermatologist and patients' self‐assessment to evaluate improvements at 3 months after the final treatment.ResultsThe treated sides exhibited a significant volume reduction, with statistically significant improvements over the control group at 1 month after the first and second treatments and at 3 months after the final treatment (p = 0.024, 0.005, and 0.019, respectively). At 3 months after the final treatment, a blinded dermatologist correctly identified the treated side in 24 of 25 patients (96%). The patients rated the improvements as excellent (>75%) and marked (50%–75%) in 36% and 48% of patients, respectively.ConclusionAt 3 months, the 1064‐nm picosecond laser with a fractionated MLA can significantly reduce the posttraumatic and postsurgical atrophic scar volume in patients with Fitzpatrick skin types III‐V. Insufficient data preclude inferences regarding efficacy at 6 months.
Dual‐channel supply chain coordination under risk aversion and fairness concerns
Authors: Xue Lin , Wang Kangzhou 
Published: May 2023

AbstractThis paper studies coordination in a dual‐channel supply chain consisting of a risk‐averse retailer with fairness concerns and a risk‐neutral and fairness‐neutral manufacturer where the market demand and manufacturer yield are both uncertain. Based on CVaR criterion and fairness concern theory, a dual‐channel supply chain decision‐making model for the risk‐averse retailer with fairness concerns is constructed, and the optimal decision under centralized and decentralized dual‐channel supply chains is discussed. A new joint contract formed from revenue‐sharing and buyback contracts is presented to coordinate the dual‐channel supply chain under yield and demand uncertainty conditions that realizes Pareto improvement. The influences of yield and demand uncertainties, the risk aversion coefficient, and the fairness concern coefficient on retailer‘s order quantity, retailer's expected utility function value, manufacturer's planned yield, and manufacturer's expected utility function value are analyzed through numerical examples. The feasible range of Pareto improvement under the joint contract is also discussed.
On selling format choice and quality differentiation in dual‐channel supply chains
Authors: Zhang Qiaoke , Mantin Benny , Chen Hongzhuan 
Published: May 2023

AbstractWhen suppliers sell products through a direct channel and an indirect channel, they usually differentiate the two channels by quality to alleviate channel conflicts. The quality choice for different channels poses a great challenge to the suppliers, which also bears implications for the online retailer's choice between the reselling format and the agency format. This paper uses a game‐theoretic model to investigate the interaction between the supplier's quality differentiation strategy and the online retailer's selling format choice in dual‐channel supply chains. Different from the previous literature, we endogenize the supplier's quality decisions and find that the supplier always chooses to sell the high‐quality product through the direct channel and sell the low‐quality product through the online retailer. Moreover, compared with the reselling format, the quality level of the low‐quality product is reduced but that of the high‐quality product is lightly increased under the agency format. The intuition is that the supplier tends to highlight the advantage of each channel to acquire more profit. Regardless of the supplier's choice, the online retailer always prefers the agency format. We further extend our model in several important directions, which lend robustness to our core insights.