bluuebunny/crossref_metadata_2025_split huggingface dataset:
O impacto do estresse na infância e doenças psiquiátricas na vida adulta: uma abordagem epigenética
Authors: Lemos Letícia , Batista Bianca Gonçalves , Maia Ivonilda de Araújo Mendonça , Cavalcante Mariana Mendonça Maia , Fachin Laercio Pol 
Published: September 2023

Introdução: Doenças de origem psiquiátricas são responsáveis por 33% de todas as patologias não-infecciosas em todo o mundo. A exposição ao estresse tóxico durante a primeira infância tem o potencial de aumentar a susceptibilidade de um indivíduo a uma série de condições neuropsiquiátricas na fase adulta. Uma maneira pela qual o estresse pode levar a alterações neurobiológicas é através de modificações epigenéticas, alterando o padrão de metilação de genes do DNA, reconhecidamente biomarcadores para desordens psiquiátricas e de regulação comportamental. Objetivo: Reunir informações sobre os efeitos epigenéticos deletérios do estresse na primeira infância, e seu impacto futuro na saúde mental do adulto. Metodologia: Trata-se de uma revisão sistemática de literatura obtida nos bancos de dados PubMed, Scielo e LILACS, no português e inglês. Foram utilizados como descritores: Adverse Childhood Experiences, Epigenetics e Mental Disorders com o operador booleano AND, durante o período de junho de 2017 a junho de 2023. Foram selecionados 11 artigos para o presente estudo, de 71 encontrados, após análise do resumo e exclusão de artigos duplicados. Resultados:Há constatação que genes profundamente vinculados ao aumento do risco para distúrbios psiquiátricos, como o transportador de serotonina SLC6A4, são excessivamente metilados em seres humanos que foram submetidos a situações estressantes na primeira infância de acordo com o grau de severidade do estresse precoce. O estresse tóxico é a resposta mais grave do organismo, gerando um aumento significativo dos níveis de cortisol e norepinefrina,hipermetilação de genes do DNA, redução da neurogênese e mudanças no eixo hipotálamo-hipófise-adrenal da criança, levando a um comprometimento cognitivo. Considerações finais: A associação entre as situações adversas na infância e mudanças no estado de metilação de numerosos genes, como o transportador de serotonina SLC6A4, pode ocasionar o aparecimento de distúrbios psiquiátricos. Dessa forma, a presente revisão expôs a necessidade do desenvolvimento de ações voltadas à prevenção e diagnóstico precoce de doenças psiquiátricas que possam ser incorporados nos programas de formação integral da criança e do adolescente para que estes contemplem e assegurem o pleno desenvolvimento das esferas física, afetiva e sócio emocional em consonância com pais e cuidadores para que fatores estressores geradores de estresse tóxico sejam mitigados.
Será que altos volumes semanais de treinamento resistido pode ser um fator de risco para diminuição na contagem de linfócitos T CD4 em portadores DE HIV/AIDS? Uma revisão de literatura
Authors: De Souza Wellington Santos , De Farias Alexandre Maia 
Published: September 2023

Em geral profissionais da saúde acreditam que altos volumes de exercícios podem trazer danos a pessoas acometidas pelo vírus da imunodeficiência humana. Porém, a literatura tem revelado aumento da contagem da células TDC4+ após a realização de programas de Treinamento resistido (TR) combinados com exercícios aeróbios ou mesmo sozinhos, sem relatar intercorrência agudas ou crônicas na imunidade destas pessoas. Contudo, restam dúvidas sobre qual seria do volume ideal de TR para maximizar o aumento das células T CD4+ de forma eficiente e segura. Desta maneira, este estudo organizou uma revisão sistemática para avaliar as respostas imunológicas crônicas relacionadas aos quantitativos celulares de linfócitos T CD4+ em pessoas portadoras do vírus HIV, obtidas em respostas a diferentes volumes semanal de séries e exercícios de TR. Para tanto, foi realizado a revisão de literatura, nas plataformas Pubmed, MEDLINE e Scielo, para coletar artigos publicados no período de 2015 a 2021. Para a seleção dos artigos, usaram-se os descritores: “Vírus da Imunodeficiência Humana”, “Aids”, “linfócitos T CD4”, “Exercício resistido”, “Treinamento de Força”, tanto em português como em inglês. Os resultados mostraram aumentos no quantitativo de células T CD4+ com a realização do TR com 18 a 30 exercícios por semana distribuídos para todas as regiões do corpo, bem como para a execução de 48 a 90 séries semanais e com volumes de repetições semanais em média entre 432 e 972 repetições. Portanto, há fortes indícios de aumento no número de células TCD4 após algumas semanas deTR, utilizando volumes de séries semanais entre 48 e 90 séries, com 18 a 30 exercícios por semana.
Eficácia da utilização de Cetamina, Esquetamina e Midazolam para pacientes com transtorno depressivo resistente ao tratamento
Authors: De Melo Izabel Rocha , Oliveira Ana Luiza Ferreira , Lessa Victor José Correia , Cavalcanti Isabela de Farias , Alves Maria Fernanda Tenório , De Lima Fernanda Gabrielle Pinto Salvador 
Published: September 2023

Introdução: O transtorno depressivo maior (TDM) é uma das principais causas mundiais de morbidade e incapacidade, estando associado a um alto risco de suicídio. Estudos têm demonstrado que a Cetamina, a Esketamina e o Midazolam são substâncias promissoras no tratamento da DRT, sobretudo, em relação aos seus efeitos antidepressivos rápidos. Objetivos: Analisar a eficácia da utilização de cetamina, esquetamina e midazolam para pacientes com transtorno depressivo resistente ao tratamento. Metodologia: Trata-se de uma revisão literária de acordo com metodologia de um scoping review (análise de escopo) com base nas recomendações do guia internacional PRISMA-ScR. Resultados: A Cetamina, Esquetamina e Midazolam demonstraram efeitos antidepressivos rápidos em um desenho de estudo otimizado, apoiando ainda mais a modulação do receptor NMDA como um novo mecanismo para melhora acelerada em formas graves e crônicas de depressão. Conclusão: As substâncias evidenciaram serem seguras na maioria dos estudos, com uma ressalva importante para pacientes idosos, necessitando de mais estudos para atestar os seus benefícios nessa faixa etária.
Impacto da pandemia de COVID-19 na saúde mental dos estudantes de medicina
Authors: Fernandes Daniela Jacó , Brandão Ana Caroline Marinho , Ávila Isadora Gundim , Cunha Ana Beatriz Magalhães , De Melo Giovanna Martins Fleury , Ahmad Iman Tareq Khamis , Lopes Isabella Isaac , Alencar Gabriela Lopes 
Published: September 2023

A Covid-19 é uma doença desde 2019, denominada como o "novo coronavirus" sars cov 2, que tem como agente o vírus,O qual tem como objetivo avaliar as consequências da pandemia da Covid-19 na saúde mental dos estudantes de medicina, durante o período de 2020 a 2022. Além dos sintomas de ansiedade, as patologias psíquicas como, o Transtorno de Ansiedade Generalizada, Síndrome do Pânico, fobia social e até mesmo, Depressão, causaram prejuízo no aprendizado dos alunos, assim como em suas formações. Trata-se de uma revisão integrativa de literatura, visto que possibilita a visão ampla da temática, ais os possíveis desfechos que essas doenças podem ter causado nos universitários. No periodo entre 2020 e 2022, escritos em inglês ou português e que se enquadram na temática da pesquisa, o que computou 33 artigos.Os quais 71,4% dos artigos foram encontrados na PubMed, enquanto 28,5% foram encontrados na LILICS. 64,2 % (n=9) dos estudos foram realizados em 2020; 14,2 % (n=2) foram feitos entre 2020 e 2021 e apenas 1 estudo (7,14%) comparou o período pré e pós pandêmico e foi desenvolvido entre 2019 e 2020.Conclui-se que a pandemia do sars cov 2 trouxe impactos tanto na vida acadêmica quanto na vida pessoal dos estudantes de medicina, o estresse, a ansiedade e a depressão foram o tripé das patologias que mais afetaram nosso público, justamente por não saberem como reagir a uma nova doença mortal no mundo a partir de 2020.
The Effect of High School Students’ Doing Sports on Self-Confidence (Sample of Kilis Province)
Authors: Yılmaz Tugay 
Published: September 2023

Aim: The aim of this research is to examine whether the sports status of high school students has any effect on their self-confidence and to examine them in terms of different variables.
Material & Method: The population of the research consists of students studying in high schools located in Kilis. The sample of the study consists of 415 students, 210 male and 205 female, randomly selected from high schools in Kilis. A personal information form developed by the researchers was used to collect information about the independent variables. The “Self-Confidence Scale”, developed by Akın (2007) as a data collection tool to measure students’ self-confidence levels, was used to determine the existing self-confidence levels of individuals. While evaluating the study data, descriptive statistical methods were used. Independent sample T-Test and ANOVA Test were used in the analysis of the data. In the analyzes used, the level of significance was determined as p<0.05.
Results: In the obtained findings, no statistical significance was found in terms of the variable of students’ gender and active sports year. Statistically significant was observed in terms of grade variable, active sports involvement variable and sports type.
Conclusion: It was concluded that high school students who do sports are more self-confident than those who do not. It was concluded that as the grade level of the student increased, the self-confidence also increased. It has been concluded that students who do team sports are more self-confident than those who do individual sports.
The Effect Of Competence And Work Discipline On Employee Performance Of The Jakarta-Bandung High-Speed Train Project
Authors: Yulianto Wahyu , Nusannas Iman Sidik , Haritsah Tania Ainun 
Published: September 2023

ABSTRACT
This study aims to determine the effect of competence on employee performance, to determine the effect of work discipline on employee performance and to determine the effect of competence and work discipline on employee performance of the Jakarta-Bandung high-speed train project. This study uses a quantitative research model. The method used in this study is the proportional stratified random sampling method, with a sample of 79 respondents from employees of PT.Sinohydro Co., Ltd. Section 2. The data collection technique uses a questionnaire that has been tested for validity and reliability using IBM SPSS 25. The results of this study indicate that the two independent variables have a positive effect on the dependent variable. The competence variable has a positive effect of 0.615 with a significance level of 0.000. The work discipline variable has a positive effect of 0.463 with a significance level of 0.000. The R square of the two variables is 0.739 or 73.9% and the remaining 26.1% is influenced by construction outside the research variables, which means that these two variables have an influence on the employee performance variable.
Keywords : Competence, Employee Performance, Work Discipline
Pengaruh Brand Ambassador K-Artist Dan Harga Terhadap Impulse Buying Produk Mie Lemonilo
Authors: Parasari Nyoman Sri Manik , Pratiwi Nuning Indah , Sari Putu Ratna Juwita , Febrianti Ni Putu Swari 
Published: September 2023

Perkembangan Korean Wave di Indonesia mendorong banyak brand Indonesia untuk menggandeng K Artist sebagai brand ambassador produk mereka, salah satunya Mie Lemonilo. Penggemar K-Artist dikenal dengan keloyalannya dalam mendukung idola mereka. Hal tersebut dapat dilihat dari terjual habisnya produk Mie Lemonilo dalam beberapa jam setelah peluncuran produk di beberapa e-commerce Indonesia. Sehingga, penelitian ini bertujuan untuk mengetahui pengaruh brand ambassador dan harga secara parsial dan simultan terhadap impulse buying produk Mie Lemonilo. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner dengan penyebaran melalui google form dan diukur menggunakan skala Likert. Sampel dalam penelitian ini sebanyak 100 responden dengan teknik pengambilan sampel menggunakan metode sampling purposive. Teknik analisis data yang digunakan dalam penelitian ini adalah Uji Asumsi Klasik, Analisis Regresi Linear Berganda, Uji Koefisien Determinasi, Uji F dan Uji T. Dari hasil penelitian dapat diketahui bahwa brand ambassador berpengaruh positif dan signifikan terhadap impulse buying, harga berpengaruh positif dan signifikan terhadap impulse buying, dan secara simultan brand ambassador serta harga berpengaruh signifikan terhadap impulse buying. Besarnya pengaruh variabel bebas terhadap impulse buying adalah 52,7%. Diharapkan dalam melakukan promosi menggunakan brand ambassador, bekerja sama dengan artis yang sudah terkenal, memiliki citra yang baik dan memiliki kemampuan yang baik dalam mempengaruhi konsumen.

Kata kunci: Brand Ambassador, Harga, Impulse Buying, Korean Wave
Dental Status of Patients with Manifestations of Lichen Planus in the Oral Cavity
Authors: Зиновенко О.Г. , Бобкова И.Л. , Садовская И.В. , Щинкевич М.В. , Барауля Т.К. 
Published: September 2023

В исследовании проведено изучение стоматологического статуса пациентов с проявлениями плоского лишая на слизистой рта. Практически каждый второй обследуемый пациент имел неудовлетворительные пломбы (48,9%) и ортопедические конструкции в ротовой полости из разнородных металлов (48,2%). Несостоятельные искусственные коронки, мостовидные протезы были выявлены в 66,4% случаев. Острые края коронок зубов при неравномерном стирании в 39,4% случаев и разрушенные кариозные зубы с острыми краями в 37,2% случаев также являются значимыми травмирующими факторами развития и прогрессирования данной патологии в ротовой полости. Практически каждый пятый обследуемый пациент имел несостоятельные съемные ортопедические конструкции (19,7%) и зубы, расположенные вне зубной дуги (19%). Большое практическое значение имеет тот факт, что при поражении плоским лишаем для слизистой оболочки рта характерна значительно более высокая ранимость. При данном заболевании присутствует положительный симптом (феномен) Кебнера, а именно появление свежих высыпаний на месте раздражения, наблюдающееся в острой (прогрессирующей) фазе. Все вышеперечисленное свидетельствует о значимости устранения местных раздражающих факторов в ротовой полости, а также профилактики их возникновения.
The study examined the dental status of patients with manifestations of lichen planus on the oral mucosa. Almost every second examined patient had unsatisfactory fillings (48,9%) and orthopedic structures in the oral cavity made of dissimilar metals (48,2%). Failed artificial crowns and bridges were identified in 66,4% of cases. Sharp edges of dental crowns with uneven erasure in 39,4% of cases and destroyed carious teeth with sharp edges in 37,2% of cases are also significant traumatic factors of the development and progression of this pathology in the oral cavity. Almost every fifth examined patient had untenable removable orthopedic structures (19,7%) and teeth located outside the dental arch (19%). Of great practical importance is the fact that when affected by lichen planus, the oral mucosa is characterized by a much higher vulnerability. With this disease, there is a positive symptom (phenomenon) Koebner, namely the appearance of fresh rashes at the site of irritation, observed in the acute (progressive) phase. All of the above indicates the importance of eliminating local irritating factors in the oral cavity, as well as preventing their occurrence.
Tongue Cleaning in Oral Hygiene. Part 2
Authors: Попруженко Т.В. , Борис С.П. 
Published: September 2023

Вопрос о чистке языка, время от времени задаваемый стоматологу, требует профессиональных, обстоятельных, не вполне очевидных ответов. Настоящий обзор соответствующей информации, почерпнутой в отечественных и зарубежных источниках, представлен в двух частях. В первой части приведены научные сведения о биологии налета на языке, а также систематизированы широко доступные потребителю суждения о социальных и медицинских задачах, предметах и методах чистки языка, изложены принципы безопасности механического контроля лингвального налета. Во второй части обзора будут представлены результаты анализа научных исследований эффективности чистки языка для решения тех или иных задач, описаны исторические и современные позиции стоматологических сообществ в отношении чистки языка.
The question about tongue cleaning, asked to dentist from time to time, requires professional, thorough, not quite obvious answers. This literature review from national and foreign sources is presented in two parts. The first part provides scientific information about the biology of lingual plaque, systematizes widely available for consumers judgments about the social and medical tasks, subjects and methods of tongue cleaning, outlined the safety principles of mechanical control of lingual plaque. The second part presents the results of scientific research analysis about effectiveness of tongue cleaning for certain tasks, historical and modern positions of the dental community regarding tongue cleaning.
Tingkat Kelayakan Jalur Pedestrian di Jalan KH. Abul Hasan, Kota Samarinda
Authors: Chairunisa Nabila Nava , Nugroho Rizky Arif , Hidayat Arief , Putra Rulliannor Syah 
Published: September 2023

Berdasarkan RTRW (Rencana Tata Ruang Wilayah) pada Kota Samarinda periode 2014 hingga 2034 menyatakan bahwa adanya rencana mengenai infrastruktur perkotaan di Jalan KH. Abul Hasan yaitu berupa penyediaan dan penggunaan sarana prasarana jaringan pedestrian di wilayah Kota Samarinda. Namun pada kenyataannya, jalur pejalan kaki di kawasan tersebut tidak memenuhi kriteria yang ditetapkan untuk pengguna jalan. Tujuan dari penelitian adalah menganalisis tingkat kelayakan jalur pedestrian bagi para pengguna jalur pedestrian dengan analisis Pedestrian Environmental Quality Index (PEQI). Metode analisis deskriptif kualitatif kuantitatif berdasarkan analisis PEQI dari observasi secara langsung dengan variabel indikator lalu lintas, desain jalur pedestrian, dan pengunaan ruang jalur pedestrian dengan sembilan sub variabel yang terdapat didalamnya. Jalan KH. Abul Hasan, Kota Samarinda pada penelitian ini dibagi menjadi tiga segmen berdasarkan peruntukkan bangunan yaitu Segmen 1 (Perdagangan dan Jasa), Segmen 2 (Pendidikan), dan Segmen 3 (Ruang Terbuka Hijau). Hasil PEQI di ketiga segmen adalah Kualitas jalur pejalan kaki dasar, dimana memiliki kualitas standart atau rata rata (dasar) dengan syarat kondisi terpenuhi, tetapi dapat ditingkatkan (III).
Anomalous Nernst thermoelectric generation in multilayer-laminated coiled magnetic wires
Authors: Uchida Ken-ichi , Kuwabara Tetsuya , Tanji Toru , Fujimoto Makoto , Nagasawa Ren , Iguchi Ryo 
Published: September 2023

Abstract
Thermoelectric generation using the anomalous Nernst effect (ANE) is demonstrated in multilayer-laminated coils comprising ferromagnetic metal wires stacked in the radial direction. By applying a temperature gradient to the coils in the radial direction, the thermoelectric voltage and power induced by the ANE appear and increase in proportion to the number of stacked layers. This device structure is useful for improving the thermoelectric performance and versatility of energy-harvesting devices based on the ANE.
The Effect of Basil Leaf Extract (Ocimum Sanctum) and Lime Water (Citrus Aurantifolia S.) For Tooth Surface Whitening
Authors: Sari Retno Dwi , Junaidi Junaidi 
Published: September 2023

The color change of the teeth caused by intrinsic or extrinsic factors is known as discoloration. The purpose of the study was to see the effectiveness of the combination of basil leaf extract and lime extract on the effect of whitening the surface of discolored teeth.
The research was quasi-experimental. The Basil leaf extract and the Lime water were prepared using the maceration method and then divided into the following groups of combination, 30%B+70%L, 40%B + 60%L, 50%B + 50%L, 60%B + 40%L, 70%B + 30%L. All extracts were tested on the prepared and stained tooth to examine the whitening effect. Data collected were analyzed using the MannWhitney Test.
The effect of staining the tooth surface before and after soaking with a combination of basil extract and lime juice extract showed no difference (p<0.05), except for the 30% basil concentration group + 70% lime juice and the 40% basil concentration group + 60 lime juice. %. There was no difference in the effectiveness of the combination of basil leaf extract and lime extract on the effect of teeth whitening staining on the control (p>0.05).
The Effectiveness of Duku Kumpeh Skin Extract Aromatherapy Candles to Repel Dengue Haemorrhagic Fever Mosquitoes
Authors: Chandra Emilia , Zunidra Zunidra , Saumi Nadia 
Published: September 2023

Dengue Hemorrhagic Fever is a health problem that has become a significant topic internationally. In Indonesia, DHF is still a disease with a high incidence rate. Quoted from the Sehat Negeriku website, in 2020, there were 95,893 cases of dengue fever, with the number of deaths from dengue reaching 661 people. To ensure a healthy life and encourage prosperity for all people of all ages to achieve goal number 3 of the Sustainable Development Goals, it is necessary to take preventive measures against this disease. The specific purpose is to know the number of dead mosquitoes with a concentration of 1% duku peel extract in wax. Knowing the number of mosquitoes killed with a duku peel extract concentration of 2% in resin, It is known that the number of dead mosquitoes with a concentration of 3% duku peel extract in wax.
This research is an experimental study with a completely randomized design (Completely Randomize Design) Duku bark extract wax was made by varying the concentration of duku bark extract to 1%, 2%, and 3%. Based on the data in the table, the highest Aedes aegypti mosquito mortality rate was obtained at a concentration of 3%, with the highest number of mosquito deaths, namely 49 mosquitoes. Whereas at a concentration of 2%, the number of mosquitoes that died was 25, and at a concentration of 3%, the number of mosquitoes that died was 25. Duku bark extract wax is categorized as good and can be used as a vegetable insecticide.
The Effect of Progressive Muscle Relaxation on Blood Pressure and Anxiety of Hypertension Patients
Authors: Abbasiah Abbasiah , Ernawati Ernawati , Novianti Reni 
Published: September 2023

Hypertension is the leading cause of premature death worldwide; hypertension management must be done correctly. Control can be divided into two, namely pharmacological management and non-pharmacological management; relaxation techniques that can be done are slow deep breathing exercises and progressive muscle relaxation. Progressive muscle relaxation (PMR) is a technique for reducing blood pressure. The study aimed to determine the impact of progressive muscle relaxation on blood pressure and anxiety in hypertension patients in the Suko Awin Jaya Health Center in 2022.
This study was a quasi-experimental quantitative study with two group pre-test and post-test designs. The population in this study was 87 hypertension sufferers in the Suko Awin Jaya Health Center working area in 2021. The sampling technique was purposive, and 76 people were included in this study. The research was carried out in June 2022 in the Working Area of the Suko Awin Jaya Health Center. Data were analyzed using the dependent T-test. The difference was considered statistically significant at p<0.05. This research found that progressive muscle relaxation affected blood pressure (p=0.000) and the anxiety level of hypertension sufferers in the Work Area of the Suko Awin Jaya Health Center (p= 0.000). It is hoped that the community can apply the interventions that health workers have taught. Thus, that blood pressure and anxiety levels are always controlled.