bluuebunny/crossref_metadata_2025_split huggingface dataset:
EPIDEMIOLOGIA AMBIENTAL
Authors: Castro José Gerley Díaz , Silva Adailton Tomaz da , Castro Larissa Possidônia , Santos Marta Azevedo dos 
Published: May 2023

A Epidemiologia Ambiental analisa como os riscos existentes (físicos, biológicos, mecânicos, ergonômicos e psicossociais) interferem na saúde das populações humanas. O presente trabalho teve como objetivo verificar as publicações sobre o tema, na Revista Brasileira de Epidemiologia. Trata-se de uma pesquisa descritiva, fundamentada numa revisão da base de dados da Revista Brasileira de Epidemiologia versão On-line ISSN 1980-5497, considerando o período de 1998 a 2021. Um total de 23 volumes distribuídos em 87 números ou edições (87%) e suplementos (13%) foram encontrados durante o período. De um total de 1258 artigos originais, 258 versaram sobre epidemiologia ambiental. Considerando os “artigos especiais”, dos 18 publicados apenas 1 versou sobre a epidemiologia ambiental. Em 2003, o número 2 do volume 6, foi dedicado ao tema epidemiologia ambiental. Todos os 8 artigos publicados tiveram como foco esse tema. Os dois temas mais frequentemente publicados estiveram ligados aos pesticidas e relacionados com o trabalho. Conclui-se que os diversos temas tratados na revista discutem informações sobre as características da exposição e dos efeitos à saúde que constituem os principais substratos em tais estudos epidemiológicos, sugerindo a importância da epidemiologia ambiental para subsidiar os tomadores de decisão sobre a prevenção de agravos nas populações humanas, via vigilância ambiental.
Pengembangan Media Pembelajaran Transmisi Continously Variable Transmission (CVT) Sepeda Motor Automatic Berbasis Video Pada Mata Kuliah Sepeda Motor Dan Motor Kecil
Authors: Dian Affan Hidayat  
Published: May 2023

Setelah diperkenalkannya pembelajaran daring di masa pandemi yang sudah berlangsung hampir dua tahun ini, pembelajaran tatap muka mengalami beberapa perubahan dalam proses belajar mengajar. Pemanfatan media pembelajaran masih belum mampu menampilkan gerakan asli dalam praktik dan kurang interaktif. Kelemahan tersebut akan dapat teratasi apabila dilakukan penyesuaian dan pengembangan media. Pada penelitian terdahulu tentang media pembelajaran berbasis video masih terdapat beberapa kekurangan dari segi audio, visual, maupun urutan materi pembelajaran. Penelitian ini bertujuan untuk mengembangkan dan mengetahui kelayakan media pembelajaran berbasis video materi sistem transmisi continuously variable transmission (CVT) pada mata kuliah sepeda motor dan motor kecil menurut ahli materi, ahli media, dan uji coba mahasiswa. Metode penelitian menggunakan Research and Development (R&D) dengan model pengembangan ADDIE. Hasil uji kelayakan media pembelajaran berbasis video mendapatkan persentase 89,41% dari validator ahli materi, 88% dari validator ahli media, dan 92% dari hasil uji coba mahasiswa. Dari hasil pengujian tersebut, maka dapat disimpulkan bahwa media pembelajaran berbasis video materi sistem transmisi continuously variable transmission (CVT) pada mata kuliah sepeda motor dan motor kecil “Sangat Layak” digunakan untuk kegiatan pembelajaran.

After the introduction of online learning during the pandemic that has been going on for almost two years, face-to-face learning has undergone several changes in the teaching and learning process. The concentration of learning media is still unable to display native movements in practice and is less interactive. These weaknesses will be resolved if adjustments and media development are made. In previous research on video-based learning media, there were still some shortcomings in terms of audio, visual, and the order of learning materials. This study aims to develop and determine the feasibility of video-based learning media for continuously variable transmission (CVT) transmission system materials in motorcycle and small motorcycle courses according to material experts, media experts, and student trials. The research method uses Research and Development (R&D) with the ADDIE development model. The results of the video-based learning media feasibility test received a percentage of 89.41% from material expert validators, 88% from media expert validators, and 92% from student trial results. From the results of these tests, it can be concluded that video-based learning media material for continuously variable transmission (CVT) transmission systems in the motorcycle and small motorcycle course "Very Feasible" is used for learning activities.
Allium sativum and Group B Streptococcus: antimicrobial and synergistic activity
Authors: Lima Sônia Maria Rolim Rosa , Gamberini Maria Thereza , Rodrigues Domingos Sávio , Junior Pedro Ismael da Silva , Torres Kátia Andrea de Menezes 
Published: May 2023

Abstract
Maternal colonization by Streptococcus agalactiae or Group B Streptococcus(GBS) during pregnancy increases the risk of neonatal infection due to vertical transmission from mother to fetus before or during labor. The study aimed to evaluate the antimicrobial activity of the SP80 fraction (obtained from Allium sativum) and its synergism associated with the antibiotic against strains of GBS. The broth microdilution was used to determine the antimicrobial activity of the SP80 and to establish the MIC of SP80 (2.40 mg/mL). By using, the disk diffusion method, fifty-five clinical isolates and 1 ATCC of GBS were tested against the association of the SP80 fraction with antibiotic PEN and AMP, respectively, for synergistic assessment. The results showed that the association of SP80 + PEN did not alter the response of PEN alone. In contrast, the association of SP80 + AMP caused the mean inhibition halos to increase with a p<0.001. The SP80 fraction has antimicrobial activity against GBS, and the association with the antibiotic AMP showed a synergistic effect, which did not occur when in association with PEN.
WITHDRAWN: A* Path Finding Algorithms Based Designing the Best Possible Eco-Friendly Structure Spatial Landscape and Natural Setting.
Authors: Imran Izazul Hoq , Das Tropa , Galib Asadullah Hel , Roy Tanni 
Published: May 2023

Abstract

The design of conventional architectural landscapes often has issues with inadequate direct visual effects and inadequate levels of resident satisfaction, but the design of green architectural landscapes typically does not have these issues. Creating room for landscaping is likewise an impractical endeavor. Because of this, the authors of this study suggest a number of different Path-finding algorithms for green building landscape space and environmental optimization design. A variety of path-finding algorithms may be used to maximize the multi-objective scale of the architectural landscape. The expense of the construction as well as public utilities such as the space environment are included among the optimization's goals and objectives. The findings indicate that the many pathfinding solutions that were presented are able to optimize the architectural landscape setting, and the occupants' level of happiness has increased as a consequence.
Effect of milk exposure on the redox profile of Caenorhabditis elegans
Authors: Oliveira Ingrid Laíse Silvestre , Silva Giovanna Melo Martins , Cadavid Cesar Orlando Muñoz , Sales Danielle Cavalcanti , Anaya Katya , Oliveira Riva de Paula , Rangel Adriano Henrique do Nascimento 
Published: May 2023

Abstract
The consumption of bovine milk and its derivatives is associated with inflammation, gastrointestinal disorders and the development of diseases in humans. Most studies related to milk effects are based on either clinal trials or experimental models such as mice and cell cultures. In this study we present the nematode Caenorhabditis elegans as an alternative model to evaluate the effects of milk on oxidative stress in other animal models. The toxicological effect of 20% milk exposure for 8h on C. elegans was evaluated by progeny quantification, body size and pharyngeal pumping rate. Treating the worms with milk did not affect the worms brood size but interfered with their fecundity by delaying the average number of eggs in the first day of oviposition when compared to the control group. The size of worms treated with milk were significantly smaller compared to control. The pharyngeal pumping rate of milk-treated animals was not significantly different compared to untreated animals. Taking together, the results suggest that 20% milk treatment is not toxic for the worms but induces a minor delay achieving its adulthood and therefore its reproduction period. Exposure milk did not reduce the worms’ survival under stress conditions and increase endogenous ROS levels. This study contributes to characterize the effects of milk exposure on the C. elegans nematode.
Association analysis of frailty with obstructive sleep apnea syndrome in elderly patients – A Multicenter Cohort Study
Authors: He Zijun , Xue Xin , Gao Yinghui , Zuo Zhang , Li Mengxi , Zhao Zhe , Zhao Libo , Su Xiaofeng , Xing Mengying , Li Tianjiao , Li Kailiang , Han Jiming , Liu Lin 
Published: May 2023

Abstract
Objective We assessed the incidence of frailty and identified the independent risk factors for the occurrence of frailty in elderly patients with obstructive sleep apnea syndrome (OSAS), which aims to provide a reference for the clinical treatment of OSAS and frailty.Methods We selected 1006 elderly patients with OSAS diagnosed using polysomnographic (PSG) between January 2015 and October 2017. We divided the patients into the non-frailty group (n = 731) and the frailty group (n = 275) based on the FRAIL scale score, compared the difference between the two groups. Multivariate cox regression analysis was used to identify the factors affecting the onset of frailty among elderly patients with OSAS.Results༚ 275 patients experienced frailty, yielding an incidence of 27.34%. Multivariate cox regression analysis showed that age(HR = 1.058, 95% CI:1.043–1.074, P < 0.001), constipation(HR = 1.490, 95%CI: 1.101–2.018, P = 0.010), carotid atherosclerosis (CA)(HR = 1.739, 95% CI: 1.299–2.330, P < 0.001), and renal insufficiency (RI)(HR = 1.878, 95% CI: 1.177–2.996, P = 0.008) are independent risk factors for frailty in elderly patients with OSAS. And platelet count(PLTC)(HR = 0.998, 95% CI: 0.996-1.000, P = 0.040), the mean arterial oxygen saturation(MSaO2)(HR = 0.950, 95% CI: 0.918–0.984, P = 0.005) are protect factors.Conclusion The incidence of frailty among elderly patients with OSAS is relatively high, and it was significantly higher in patients with severe OSAS than in those with mild or moderate OSAS. Age, constipation, CA, and RI are independent risk factors, whereas mean oxygen saturation and platelet count are protective factors for frailty in elderly patients with OSAS.
Is Streptococcus mutans count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis
Authors: Manchanda Sheetal , Sardana Divesh , Peng Simin , Lo Edward CM , Chandwani Neeta , Yiu Cynthia LY 
Published: May 2023

Abstract
Background The review aims to determine the risk predictability of S. mutans in the development of carious lesions in children with primary dentition.Methods Longitudinal observational studies with at least 6 months follow-up and evaluating S. mutans presence in caries-free children less than 6 years of age for the development of any cavitated or non-cavitated carious lesion. Six databases and grey literature were searched without any restrictions. Risk of bias was evaluated using New Castle Ottawa scale for longitudinal studies and the certainty of evidence was evaluated by Grading of Recommendations Assessment, Development and Evaluation using GRADEpro software. Meta- analysis was performed using a random effect (DerSimonian and Laird, DL) model and heterogeneity was evaluated using tau-squared, I² statistics and prediction interval. Sensitivity analysis was performed to assess the relationship between the S. mutans presence at baseline and the caries development, according to the sample and methods used for the microbiological assessment and the length of follow-up of the studies. Publication bias was checked by funnel plot using a random effect (DerSimonian and Laird, DL) model.Results Twelve studies met the inclusion criteria and were included in the review. Four studies received a maximum of 9 stars and among the remaining eight studies, six received 8 stars and the rest two studies were assigned 7 stars in the risk of bias scale. After pooling the results quantitatively, odds ratio (OR) was found to be 4.13 (95% CI: 3.33, 5.12), suggesting that children with S. mutans had 4 times higher odds of developing caries later (p < 0.001). Four studies were pooled to compare future caries experience among children with and without S. mutans at baseline, obtaining standardized mean difference (SMD) of 0.85 (95% CI: 0.33, 1.37), indicating large effect (p < 0.001). Certainty of evidence was found to be high, and no publication bias was reported by the funnel plot criteria of symmetry.Conclusions Presence of S. mutans in a preschool child is a risk predictor for future caries experience. Early identification of children with increased caries-risk may facilitate in implementation of appropriate preventive strategies.
Restoration and Sustainability of Earthen Architecture: Ksar Khanguet Sidi Nadji in the Algerian Sahara as a Case Study
Authors: Zaghez Imen , Attoui Redha , Saou-Dufrêne Bernadette Nadia 
Published: May 2023

Abstract

Earthen architecture has a rich history of providing durable and sustainable shelter for humans. However, many of these heritage sites are now facing abandonment and obsolescence. Kasr Khanguet Sidi Nadji in the Algerian Sahara is not exempt from this reality. To address this critical situation, we propose a sustainable, eco-friendly, and cost-effective solution for the restoration of the Ksar that takes into account the needs of its residents and its heritage value. Our approach utilizes the anastylosis method which implies that we reuse original on-site components as building materials whenever possible. We introduce new materials only when necessary after subjecting them to rigorous testing and control. Additionally, we take into account the complex challenges of human, natural, and technical factors involved in the restoration process, offering a practical solution to restore and preserve the earthen heritage of the Ksar while benefiting its residents.
The Transcriptional Landscape of Pericytes in Acute Ischemic Stroke
Authors: Buizza Carolina , Enström Andreas , Carlsson Robert , Paul-Visse Gesine 
Published: May 2023

Abstract
The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. Novel therapeutic approaches that can be given beyond the limited time window of 3–4.5 hours are still an unmet need to be addressed to improve stroke outcomes. The lack of oxygen and glucose in the area of ischemic injury initiates a pathological cascade leading to blood-brain barrier (BBB) breakdown, inflammation and neuronal cell death, a process that may be intercepted to limit stroke progression. Pericytes located at the blood/brain interface are one of the first responders to hypoxia in stroke and therefore a potential target cell for early stroke interventions. Using single-cell RNA sequencing in a mouse model of permanent middle cerebral artery occlusion, we investigated the temporal differences in transcriptomic signatures in pericytes at 1, 12, and 24 hours after stroke. Our results reveal a stroke-specific subcluster of pericytes that is present at 12 and 24 hours and characterized by the upregulation of genes mainly related to cytokine signalling and immune response. This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets.
An improved butterfly optimization algorithm and its application in cascade hydropower generation operation
Authors: Xiao Zhangling , Liang Zhongmin , Wang Jian , Li Binquan , Hu Yiming , Wang Jun 
Published: May 2023

Abstract

Cascade reservoir operation is an effective nonstructural countermeasure for water resources management. In recent years, many metaheuristic algorithms are introduced to handle reservoir optimal operation due to their strong search capability and high efficiency. The butterfly optimization algorithm (BOA) is a newly developed metaheuristic method which has been widely used in solving various optimization problems. But it has local convergence and premature problems. Therefore, this paper proposed an improved version of BOA where three strategies are introduced: (1) the self-adaptive strategy to improve the initial population, (2) the dynamic switch strategy to balance exploration and exploitation, (3) the Levy-flight and standardized fragrance operators for position updating. The feasibility of the BOA, and IBOA are verified and compared with several commonly used algorithms (PSO, SCA, WOA and TSA) based on 19 test functions. Then, these methods are applied to address the optimization of cascade reservoirs that aims to maximize total hydropower generation. The results show that the proposed IBOA produces higher hydropower output and more stable results, indicating better scheduling schemes than BOA and the other four algorithms. In conclusion, IBOA is an effective and robust alternative optimization tool for cascade reservoir operation problems.
Mitapivat: A Novel Treatment of Hemolytic Anemia in Adults with
Pyruvate Kinase Deficiency
Authors: De Surya K. 
Published: May 2023

Abstract:
Mitapivat is an orally bioavailable small molecule allosteric activator of pyruvate
kinase. It was approved by the US FDA on February 17, 2022, and the European
Union in November 2022 for the treatment of hemolytic anemia in adult patients with pyruvate
kinase deficiency. In this short perspective, physicochemical properties, synthesis,
dosage and administration, mechanism of action, pharmacodynamics, pharmacokinetics,
drug interactions, and adverse reactions of mitapivat are described.
The Potential of Stem Cells in Treating Breast Cancer
Authors: Yadav Deepika , Sharma Pramod Kumar , Mishra Prem Shankar , Malviya Rishabha 
Published: May 2023

Abstract:
There has been a lot of interest in stem cell therapy as a means of curing disease in recent
years. Despite extensive usage of stem cell therapy in the treatment of a wide range of medical diseases, it
has been hypothesized that it plays a key part in the progression of cancer. Breast cancer is still the most
frequent malignancy in women globally. However, the latest treatments, such as stem cell targeted therapy,
are considered to be more effective in preventing recurrence, metastasis, and chemoresistance of
breast cancer than older methods like chemotherapy and radiation. This review discusses the characteristics
of stem cells and how stem cells may be used to treat breast cancer.
Clinicomycological Profile and Risk Factors for Dermatophytosis at a
Teaching Tertiary Care Centre in North India: A Cross-sectional Study
Authors: Singla Pooja , Garg Sima , Singh Prashant , Sharma Nidhi , Mane Pratibha , Singh Nand Kishore , Sharma Sudhanshu 
Published: May 2023

Background:
Dermatophytosis has gained significant importance in recent years owing to
increased incidence, more atypical lesions, changing mycological profile and growing antifungal resistance.
Therefore, this study was planned to know the clinicomycological profile of dermatophytic
infections in patients attending our tertiary care centre.s gained significant importance in recent years owing to
increased incidence, more atypical lesions, changing mycological profile and growing antifungal resistance. Therefore, this study was planned to know the clinicomycological profile of dermatophytic
infections in patients attending our tertiary care centre.

Materials and Methods:
A total of 700 patients with superficial fungal infections belonging to all age
groups and both sexes were taken up for this cross-sectional study. Sociodemographic and clinical
details were noted on a prestructured proforma. Superficial lesions were clinically examined and the
sample was collected by appropriate collection methods. Direct microscopy by potassium hydroxide
wet mount was done to see hyphae. For culture Sabouraud’s dextrose agar (SDA) with chloramphenicol
and cyclohexamide was used.

Results:
Dermatophytic infections were detected in 75.8% (531/700) patients. Young people belonging
to age group of 21-30 years were commonly affected. Tinea corporis was the commonest clinical picture
seen in 20% of the cases. Oral antifungals were taken by 33.1% and topical creams were used by
74.2% of the patients. Direct microscopy was positive in 91.3% and culture was positive for dermatophytes
in 61% of the study subjects. T. mentagrophytes was the commonest dermatophyte isolated.

Conclusion:
Irrational use of topical steroids needs to be controlled. KOH microscopy can be useful as
a point of care test for rapid screening of dermatophytic infections. Culture is necessary to differentiate
various dermatophytes and to guide the antifungal treatment.
Is Daclatasvir a Suitable Substitute for Amphotericin B in the Treatment
of Mucormycosis when Amphotericin B is Scarce?
Authors: Thangaraju Pugazhenthan , Tanguturi Yella Sree Sudha , Arumugam Ramamurthy Vijayakumar , Muthusamy Sivakumar , Mohamed Thameemul Ansari Lappathai Habib , Navabshan Irfan , Venkatesan Sajitha 
Published: May 2023

Background:
Mucormycosis has been infesting the universe for a while back, often
with no prompt treatments. The disease devastation is spreading at an alarming rate. Many researchers
are still hoping for a good potential drug that could help the healthcare system in this
tussle. Molecular docking is an in silico tool that has gained popularity over the last few decades.
Knowing the mechanism of enzymatic action is aided by imitating membrane protein actions in
binding ligands.

Aim:
The aim of this perspective is to determine whether an existing drug, daclatasvir, has antifungal
activity.

Objective:
The primary objective of this in silico study was to investigate the potential effects of
the binding affinity of daclatasvir with the crucial protein (1XFF) of mucormycosis, as well as the
binding pattern of the active site amino acids with the drug molecule.

Materials and Methods:
To calculate the binding affinity of daclatasvir to the fungal protein
1XFF, Auto Dock Vina was used for molecular docking studies. The CDOCKER protocol was
used to determine the receptor-ligand interaction by configuring various parameters.

Results:
The docking energy of the ligand (daclatasvir) on the protein (1XFF) was found to be -
16.7216 kcal/mol, while the interaction energy was found to be -42.1314 kcal/mol.

Conclusion:
The binding pattern completely alters the dynamics of the protein, resulting in the
breakdown of the fungal wall. The vital protein (1XFF) of Rhizopus oryzae is proposed as a possible
protein target for the non-structural protein 5A inhibitor/antiviral drug daclatasvir in this
study.