bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passive array micro-magnetic stimulation device based on multi-carrier wireless flexible control for magnetic neuromodulation
Authors: Tian Lei , Zhao Tong , Dong Lei , Liu Qiwen , Zheng Yu 
Published: September 2023

Abstract

Objective. The passive micro-magnetic stimulation (µMS) devices typically consist of an external transmitting coil and a single internal micro-coil, which enables a point-to-point energy supply from the external coil to the internal coil and the realization of magnetic neuromodulation via wireless energy transmission. The internal array of micro coils can achieve multi-target stimulation without movement, which improves the focus and effectiveness of magnetic stimulations. However, achieving a free selection of an appropriate external coil to deliver energy to a particular internal array of micro-coils for multiple stimulation targets has been challenging. To address this challenge, this study uses a multi-carrier modulation technique to transmit the energy of the external coil. Approach. In this study, a theoretical model of a multi-carrier resonant compensation network for the array µMS is established based on the principle of magnetically coupled resonance. The resonant frequency coupling parameter corresponding to each micro-coil of the array µMS is determined, and the magnetic field interference between the external coil and its non-resonant micro-coils is eliminated. Therefore, an effective magnetic stimulation threshold for a micro-coil corresponding to the target is determined, and wireless free control of the internal micro-coil array is achieved by using an external transmitting coil. Main results. The passive µMS array model is designed using a multi-carrier wireless modulation method, and its synergistic modulation of the magnetic stimulation of synaptic plasticity long-term potentiation in multiple hippocampal regions is investigated using hippocampal isolated brain slices. Significance. The results presented in this study could provide theoretical and experimental bases for implantable micro-magnetic device-targeted therapy, introducing an efficient method for diagnosis and treatment of neurological diseases and providing innovative ideas for in-depth application of micro-magnetic stimulation in the neuroscience field.
Progress in the studies of electronic and magnetic properties of layered MPX3 materials (M: transition metal, X: chalcogen)
Authors: Dedkov Yuriy , Guo Yefei , Voloshina Elena 
Published: September 2023

Abstract
The recent progress in the studies of 2D materials placed in front many experimental and theoretical works on the interesting class of materials, the so-called transition metal phosphorus trichalcogenides with structural formula MPX3 (M: transition metal, X: chalcogen). Here, the diversity in the M/X combination opens the possibility to tune the electronic and magnetic properties of these materials in a very wide range, resulting in many interesting physical phenomena followed by the promoting their use in different application areas. This review gives a timely overview of the recent progress in the fundamental studies of electronic structure and magnetic properties of MPX3 materials (M: Mn, Fe, Co, Ni, X: S, Se) focusing on the results obtained by density functional theory, Raman spectroscopy and electron spectroscopy methods. We pay close attention to the large amount of theoretical and experimental data giving critical analysis of the previously obtained results. It is shown how the systematic fundamental studies of the electronic and magnetic properties of MPX3 can help to understand the functionality of these interesting 2D materials in different applications, ranging from optoelectronics to catalysis.
Was the extreme rainfall that caused the August 2022 flood in Pakistan predictable?
Authors: Malik Iqura , Chuphal Dipesh Singh , Vegad Urmin , Mishra Vimal 
Published: September 2023

AbstractPakistan suffered from severe floods in the past, but in August 2022, the country experienced exceptional extreme rainfall events that caused widespread and catastrophic flooding. The 2022 flood affected all aspects of socio-economic lives including agriculture, infrastructure, and mortality of humans and livestock. The two-day accumulated extreme rainfall on 17–18 August was anomalous and contributed the most to the flood in the southern provinces of Pakistan. The damage caused by extreme rainfall and the subsequent flooding has raised questions regarding the predictability of extreme rainfall by the existing weather forecasting models. Here, we use ensemble forecasts from four numerical weather prediction models under THORPEX Interactive Grand Global Ensemble datasets to examine the predictability of extreme rainfall at a six-day lead. The extreme precipitation during 17–18 August 2022 was predictable a week before the event that contributed the most to the flooding. All the forecast models provided an early warning at a six-day lead time. UK Meteorological Office and European Centre for Medium-Range Weather Forecasts models produced comparable results to observations at all the lead times. Our findings highlight that an integrated framework of extended quantitative precipitation forecasts and hydrological modeling can help reduce the country’s flood vulnerability and risk associated with it.
Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovary
Authors: Kondo Yoshiko , Rajapakse Sanath , Ogiwara Katsueki 
Published: September 2023

Abstract
Cathepsin L plays physiological and pathological roles in immune responses, cancer, metamorphosis, and oogenesis in several species. However, the function of Cathepsin L in medaka ovaries remains unclear. Therefore, here, we examined the physiological functions of Cathepsin L in the medaka ovaries. Cathepsin L mRNA transcripts and proteins were found to be constitutively expressed in the ovaries of Oryzias latipes over a 24-h spawning cycle. Expression was localized within the oocyte cytoplasm of growing follicles and the follicle layer of preovulatory and postovulatory follicles. Moreover, the active form of Cathepsin L was highly expressed in the follicle layer of periovulatory follicles and the ovaries 2–6 h after ovulation. Recombinant Cathepsin L was activated under acidic conditions and exhibited enzymatic activity in acidic and neutral pH conditions. However, extracellular matrix proteins were degraded by recombinant Cathepsin L under acidic, not neutral pH conditions. Cathepsin L was secreted from preovulatory follicles, while active recombinant Cathepsin L was detected in the conditioned medium of a medaka cell line, OLHNI-2. Mechanistically, recombinant Cathepsin L activates recombinant urokinase-type plasminogen activator-1, which is expressed within the follicle layers post-ovulation. Meanwhile, the treatment of medakas with an E-64 or anti-Cathepsin L antibody effectively blocked follicular layer degeneration and degradation after ovulation, whereas in vitro ovulation was not inhibited by either. Collectively, the findings of this study indicate that although Cathepsin L does not impact ovulation in medakas, it contributes to the degeneration and degradation of the follicle layers following ovulation via activation of urokinase-type plasminogen activator-1, and not via the degradation of extracellular matrix proteins.
HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp
Authors: Zhang Yuan , Grice Sophie , Wang Na , Liu Yongxia , Zhao Qing , Liu Tingting , Sun Lele , Mi Zihao , Wang Jianwen , Yu Gongqi , Zhang Fan , Meng Xiaoli , Liu Hong , Naisbitt Dean J , Sun Yonghu , Zhang Furen 
Published: September 2023

AbstractEpidermal growth factor receptor inhibitors (EGFRIs) are widely used to treat various types of malignancies. One of the common adverse reactions is cutaneous toxicity, mostly presenting as acneiform eruptions, paronychia and xerosis. Erosive pustular dermatosis of the scalp (EPDS) is a rare cutaneous adverse reaction that develops during treatment with EGFRIs. The pathogenesis of EGFRI-induced EPDS is poorly understood. Here we present three cases of EPDS induced by EGFRIs. The proteins LTA4H (leukotriene A-4 hydrolase), METAP1 (methionine aminopeptidase 1), BID (BH3-interacting domain death agonist), SMAD1 (mothers against decapentaplegic homologue), PRKRA (interferon-inducible double-stranded RNA-dependent protein kinase activator A), YES1 (tyrosine-protein kinase Yes) and EGFL7 (epidermal growth factor-like protein 7) were significantly upregulated in EGFRI-stimulated peripheral blood mononuclear cell cultures, and validated in the lesions. All of the proteins colocalized with CD4+ and CD8+ T-cell expression. Next-generation-based human leucocyte antigen (HLA) typing showed all patients carried HLA-C*15:02, and modelling studies showed that afatinib and erlotinib bound well within the E/F binding pockets of HLA-C*15:02. Moreover, T cells were preferentially activated by EGFRIs in individuals carrying HLA-C*15:02. The case series revealed that EGFRI-induced EPDS may be mediated by drug-specific T cells.
Urine MMP7 as a kidney injury biomarker
Authors: Avello Alejandro , Guerrero-Mauvecin Juan , Sanz Ana Belen 
Published: September 2023

ABSTRACT
Matrix metalloproteinase 7 (MMP-7) is a secreted endopeptidase involved in the degradation of extracellular matrix components and the activation of cytokines and growth factors. The regulation of MMP-7 can be transcriptionally regulated by AP-1 or Wnt/β-catenin or post-translationally by proteolytic activation. MMP-7 expression is low or absent in the healthy kidney, but is significantly upregulated in kidney injury, including AKI and CKD. The function of MMP-7 in kidney disease may differ for CKD and AKI; it may have a profibrotic role in CKD and an anti-apoptotic and regenerative function in AKI. Additionally, the potential of MMP-7 as a biomarker has been studied in different kidney diseases, and the results are promising. Recently, combined unbiased kidney proteomics and transcriptomics approaches identified kidney MMP-7 as the protein having the strongest association with both fibrosis and eGFR and confirmed the predictive role of plasma MMP-7 levels for kidney function decline in over 11 000 individuals. Additionally, urinary MMP-7, combined with urinary cystatin C (CysC) and retinol binding protein (RBP) was reported to provide information on tubular injury in focal segmental glomerulosclerosis and minimal change disease. We now present an overview of research on MMP-7 expression and function in kidney diseases and discuss its potential as a biomarker of kidney diseases.
Information intervention on long-term earnings prospects and the gender gap in major choice
Authors: Peter Frauke , Schober Pia , Spiess C Katharina 
Published: September 2023

Abstract
This study investigates whether an intervention that provided high school seniors with information on costs and economic returns to tertiary education and on the long-term earnings prospects of college graduates from different study fields enhances the probability that male and female students opt for financially more rewarding study fields and for business-related or STEM fields with a lower share of women. It extends our understanding on the potentials of information interventions for reducing gender segregation in tertiary education. We draw on a field experiment in one German federal state, Berlin, which included a randomized information intervention, and analyse longitudinal data from 1,036 students in schools with a high share of less privileged students. Our results show that a short and low-cost information intervention on costs and returns to college education, including returns in different fields of study, can substantially reduce women’s enrolment in care/social subjects, increase their enrolment in other, non-technical fields while also increasing men’s enrolment in technical fields with above-average earnings. The overall effects appear limited in challenging the gender-typicality of enrolment choices, as students tend to choose more profitable majors while avoiding gender-atypical fields.
Suggesting disease associations for overlooked metabolites using literature from metabolic neighbors
Authors: Delmas Maxime , Filangi Olivier , Duperier Christophe , Paulhe Nils , Vinson Florence , Rodriguez-Mier Pablo , Giacomoni Franck , Jourdan Fabien , Frainay Clément 
Published: September 2023

Abstract
In human health research, metabolic signatures extracted from metabolomics data have a strong added value for stratifying patients and identifying biomarkers. Nevertheless, one of the main challenges is to interpret and relate these lists of discriminant metabolites to pathological mechanisms. This task requires experts to combine their knowledge with information extracted from databases and the scientific literature. However, we show that most compounds (&gt;99%) in the PubChem database lack annotated literature. This dearth of available information can have a direct impact on the interpretation of metabolic signatures, which is often restricted to a subset of significant metabolites. To suggest potential pathological phenotypes related to overlooked metabolites that lack annotated literature, we extend the “guilt-by-association” principle to literature information by using a Bayesian framework. The underlying assumption is that the literature associated with the metabolic neighbors of a compound can provide valuable insights, or an a priori, into its biomedical context. The metabolic neighborhood of a compound can be defined from a metabolic network and correspond to metabolites to which it is connected through biochemical reactions. With the proposed approach, we suggest more than 35,000 associations between 1,047 overlooked metabolites and 3,288 diseases (or disease families). All these newly inferred associations are freely available on the FORUM ftp server (see information at https://github.com/eMetaboHUB/Forum-LiteraturePropagation).
Belief maintenance as a media effect: a conceptualization and empirical approach
Authors: Shehata Adam , Thomas Fabian , Glogger Isabella , Andersen Kim 
Published: September 2023

Abstract
While prominent theories of media effects suggest that the maintenance of societal perceptions (and misperceptions) is a critical and distinct outcome of exposure to mediated communication, the “maintenance effect” remains poorly understood. This article provides a theoretical conceptualization and operational approach to the maintenance effect. The first part addresses the distinct properties of the maintenance effect and proposes a conceptualization anchored in theories of cognitive media effects. The second part focuses on the psychological mechanisms behind the maintenance effect, outlining factors operating in the short and long run. Finally, building upon recent statistical developments for longitudinal data analysis, the third part suggests and illustrates a specific empirical approach for analyzing the maintenance effect.
Organic Synthesis
Authors: Thomas Susan E. 
Published: September 2023

Abstract

Organic Synthesis describes the properties and reactions of organoboranes and organosilanes, emphasizing how they can be used to provide simple solutions to a variety of synthetic problems. Compounds of boron and silicon are widely used in organic synthesis, and their study forms a core in many chemistry courses. Helpful study questions are provided at the end of each section, and the suggested further reading provides a useful guide to more advanced work in the field.
Adsorption and desorption
Authors: Atkins Peter , de Paula Julio , Friedman Ronald 
Published: September 2023

Contents

Adsorption isotherms	922

The Langmuir isotherm	922

Using the Langmuir isotherm	923

The isosteric enthalpy of adsorption	924

Measuring the isosteric enthalpy of adsorption	925

The BET isotherm	925

Using the BET isotherm 927...
An international survey-based assessment of minimally invasive mitral valve surgery
Authors: Fatehi Hassanabad Ali , Imran Hamid Umar , Sardari Nia Peyman 
Published: September 2023

Abstract

OBJECTIVES
Minimally invasive mitral valve surgery (MIMVS) has been shown to be safe and feasible however its adoption has lagged globally. The international consortium is lacking a set of guidelines that are specific to MIMVS. The aim of this study was to capture the practices of MIMVS in different centres.

METHODS
A survey was constructed containing 52 multiple-choice and open-ended questions about various aspects of MIMVS. The survey was sent to centres that routinely and frequently perform MIMVS. All surgeons provided informed consent for participating in the survey and publication of data.

RESULTS
The survey was sent to 75 known surgeons from whom 32 (42%) completed the survey. All survey responders performed &gt;25 MIMVS cases annually. Twenty (68%) of the surgeons thought that simulation training, MIMVS fellowship and proctorship are all essential prior to commencing an MIMVS program. Eleven (34%) of the surgeons stated that 50–100 MIMVS cases are required to overcome the learning curve, followed by 6 (18%) who said 21–30 cases should suffice. Eighteen (62%) of the surgeons had adopted a fully endoscopic approach for their MIMVS, followed by 15 (51%) surgeons who had performed cases via endoscopic-assisted strategies, 5 (17%) surgeons had conducted the operation under direct visualization and 6 (20%) surgeons had used a robot for their MIMVS.

CONCLUSIONS
The study highlights a marked variability on training and approach to MIMVS. Consensus guidelines should be established to allow standardization of MIMVS.
Masculinity Crisis or Intergenerational Perceptual Biases? Explicating Public Acquiescence to the Media Regulation on Effeminate Masculinity
Authors: Yang Xinying , Qiu Hongfeng 
Published: September 2023

AbstractBy drawing on the perspective of the third-person effect (TPE), this study explains Chinese men’s general acquiescence to the nation’s recent media regulation on effeminate masculinity. Data were collected among Chinese male netizens through an online cross-sectional survey (N = 735) and processed using a paired samples t-test, regression analysis, and mediation test. The statistical results demonstrate that public silence is not based on their perception of a masculinity crisis but rather a generation gap in self-other perceptual biases that conceive the younger generation as more susceptible to the influence of effeminate male media figures. Furthermore, the study found that media exposure, perceived desirability, critical media literacy, and gender ideology significantly predicted respondents’ related perceptions through the mediation of social distance. While frequent media exposure and positive media portrayals have demonstrated a potential for reducing prejudice against nonconventional gender performances, the recent official restriction on effeminate masculinity may perpetuate this prejudice. Overall, this study enriches the literature on the TPE by comparing intergenerational differences in perceptual biases regarding the social implications of media portrayals of effeminate masculinity.
External Validation of the Discriminative Validity of the ReSVinet Score and Development of Simplified ReSVinet Scores in Secondary Care
Authors: Sheikh Zakariya , Potter Ellie , Li You , Drysdale Simon B , Wildenbeest Joanne G , Robinson Hannah , McGinley Joseph , Lin Gu-Lung , Öner Deniz , Aerssens Jeroen , Justicia-Grande Antonio José , Martinón-Torres Federico , Pollard Andrew J , Bont Louis , Nair Harish 
Published: September 2023

Abstract

Background
There is no consensus on how to best quantify disease severity in infants with respiratory syncytial virus (RSV) and/or bronchiolitis; this lack of a sufficiently validated score complicates the provision of clinical care and, the evaluation of trials of therapeutics and vaccines. The ReSVinet score appears to be one of the most promising; however, it is too time consuming to be incorporated into routine clinical care. We aimed to develop and externally validate simplified versions of this score.

Methods
Data from a multinational (the Netherlands, Spain, and United Kingdom) multicenter case-control study of infants with RSV were used to develop simplified versions of the ReSVinet score by conducting a grid search to determine the best combination of equally weighted parameters to maximize for the discriminative ability (measured by area under the receiver operating characteristic curve [AUROC]) across a range of outcomes (hospitalization, intensive care unit admission, ventilation requirement). Subsequently discriminative validity of the score for a range of secondary care outcomes was externally validated by secondary analysis of datasets from Rwanda and Colombia.

Results
Three candidate simplified scores were identified using the development dataset; they were excellent (AUROC &gt;0.9) at discriminating for a range of outcomes, and their performance was not significantly different from the original ReSVinet score despite having fewer parameters. In the external validation datasets, the simplified scores were moderate to excellent (AUROC, 0.7–1) across a range of outcomes. In all outcomes, except in a single dataset for predicting admission to the high-dependency unit, they performed at least as well as the original ReSVinet score.

Conclusions
The candidate simplified scores developed require further external validation in larger datasets, ideally from resource-limited settings before any recommendation regarding their use.
Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus
Authors: van de Weg Cornelia A M , Thomazella Mateus V , Marmorato Mariana P , Correia Carolina A , Dias Juliana Z C , Maestri Alvino , Zanella Luiz G F A B E , Cerqueira Natalia B , Félix Alvina C , Moreira Carlos H V , Buccheri Renata , Costa Priscilla R , Kallás Esper G 
Published: September 2023

Abstract
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
Evaluating Japan’s defense cooperation agreements and their transformative potential: upgrading strategic partnerships with Australia and the UK
Authors: Baldauff Nanae , Heng Yee-Kuang 
Published: September 2023

Abstract
Japan’s defense cooperation agreements (DCAs) have been proliferating in recent years. Despite Japan’s harsh security environment, rather than expanding formal military alliances beyond its sole US ally, DCAs have emerged as a crucial instrument deployed by Japan to strengthen bilateral and minilateral defense relations with various partners. How do we make sense of Japan’s growing activism in forging DCAs? Yet, there does not currently exist a framework to systematically evaluate these DCAs, nor is there a detailed assessment of the utility of these DCAs in transforming Japan’s partnerships with like-minded states. This article proposes an analytical matrix derived from several key performance indicators and applies it to evaluate how Japan’s use of DCAs has transformed its defense relationships with two key strategic partners, Australia and the UK.