bluuebunny/crossref_metadata_2025_split huggingface dataset:
P1105 Reswitching Anti-TNF’s as Third-Line Biologic Therapy After Second-Line Failures: Factors Influencing Outcomes
Authors: Akpınar A , Gur M B , Bakkaloglu O K , Vatansever H , Eskazan T , Hatemi A I , Erzin Y Z , Celik A F 
Published: January 2025

Abstract

Background
Anti-TNF agents may show different response profiles when reintroduced after discontinuation due to nonresponse or allergy. This study aims to evaluate and compare the efficacy and side effect profiles of anti-TNF agents in patients who underwent a re-switch.

Methods
A retrospective cohort of 53 patients (41 treated with infliximab [IFX], 12 with Adalimumab [ADA]) was analysed between 2005 and 2024. All patients had previously discontinued anti-TNF therapy, which was later re-switch. Premedication was administered during re-switch for patients receiving infliximab treatment to reduce the risk of allergic reactions.

Results
Of the 53 patients, 47 (89%) had Crohn’s disease (CD), and 33 (62%) were male, with a mean age of 28 ± 12.6 years. Patient characteristics, doses used before re-switch, doses at reintroduction, and maximum doses achieved are summarized in Table 1a. Treatment discontinuation due to lack of response occurred in 73% of patients during the initial use of the drug. Approximately half of the patients, (54% with IFX and 50% with ADA), switched medications without dose escalation. The summary of the reasons why patients discontinued their initial anti-TNF treatment is presented in Table-2b. Of the 53 patients who underwent re-switch, 22 (42%) continue treatment. Among the 17 patients receiving IFX, 6 achieved radiological fistula closure (5 on 10 mg/kg/4w, 1 on 10 mg/kg/8w), and 11 achieved endoscopic remission (2 on 5 mg/kg/8w, 2 on 10 mg/kg/8w, 7 on 10 mg/kg/ 4w). Among the 5 patients receiving ADA, 1 achieved radiological fistula closure with 80 mg/7 days, and 3 achieved endoscopic remission (2 on 80 mg/7 days, 1 on 40 mg/7days). In 31 patients (58%), treatment was discontinued or changed after re-switch due to allergic-like adverse effects, lack of response, or the patient being lost to follow-up. Details are provided in Table 2a. In the IFX re-switch group, 23 patients (56%) reinitiated treatment with the standard dose, while in the ADA group, 4 patients (33%) started with the standard dose. In the total reswitch group, median CRP at initial treatment was 11 (23) and 13 (20) before medication change, with no significant difference (p: 0.386). The CRP course of patients who underwent reswitch is presented in Table-1b.

Conclusion
This study demonstrates that re-switching anti-TNF therapy can lead to significant clinical improvements, particularly in terms of CRP reduction, particularly in patients who could not be given optimum dose adjustment previously. Approximately 42% of patients continued treatment after re-switch, showing notable radiological and endoscopic improvements. These findings highlight re-switching as a viable option and the importance of proper dose adjustment before concluding treatment failure.
P1114 Engineering and Development of a Novel Bispecific Antibody Targeting IL-23 and TL1A
Authors: Huang J , Ran H , Zhang X , Li S , Su C , Dong L , Chen C , He Y , Liu D , Xu X , Chen X , Wang Y , Fei K , Tian J , Tian L , Peng J , Zhu Z 
Published: January 2025

Abstract

Background
Both IL23 and TL1A are clinically validated targets with genetical linkage to various human autoimmune diseases. Here we engineered and produced HXN-1003, a bispecific antibody (bsAb) simultaneously targeting both IL23 and TL1A, with the aim to further enhance clinical efficacy, and to overcome refractory and resistance associated with single-target based therapies.

Methods
The binding and blocking efficacy of HXN-1003 for each target were assessed using various in vitro assays, including IL23 reporter and mouse splenocyte activation assays for IL23, and TF-1 apoptosis and DR3-NFκB-Luc reporter assays for TL1A. The synergistic effect of dual targeting was measured by IL22 secretion in mouse splenocytes co-stimulated with IL23 and TL1A. In vivo efficacy was evaluated in hIL23/hTL1A transgenic mice with DSS-induced colitis and IMQ-induced psoriasis models, as well as in SD rats with subcutaneous injections of hTL1A and hIL23 to induce dermatitis.

Results
HXN-1003 features a tetravalent structure, with the anti-IL23 arm specifically binds to the p19 subunit of IL23, demonstrating superior affinity and blocking activity compared to benchmark Risankizumab. For TL1A, HXN-1003 binds to both the TL1A trimer and monomer with sub-nanomolar affinity, exhibiting similar blocking activity to its parent antibody HXN-1001 and RVT-3101. In the mouse splenocyte activation assay induced by IL23 and TL1A, HXN-1003 showed greater activity than each individual antibody and was equally active to their combination. In animal models, HXN-1003 significantly alleviated symptoms of DSS-induced colitis, and demonstrated superior therapeutic effects in the IMQ-induced psoriasis model compared to the IL23 monoclonal antibody. Additionally, in the dermatitis model induced by hTL1A and hIL23, the bsAb outperformed each individual antibody and their combination.

Conclusion
HXN-1003 simultaneously blocks IL23 and TL1A, with each arm exhibiting activity comparable to the parent monoclonal antibodies. It has demonstrated synergistic/additive therapeutic effects in both in vitro and in vivo experiments, highlighting its potential to enhance clinical efficacy and benefit autoimmune patients in multiple clinical settings.
P1117 A 24-year, single-centre perianal fistulizing Crohn’s disease cohort: documentation of demographics and factors influencing clinical and radiological remission
Authors: Bayar M , Bakkaloglu O K , Sirolu S , Sari E , Hamid R , Tutar O , Eskazan T , Hatemi A I , Erzin Y Z , Celik A F 
Published: January 2025

Abstract

Background
Radiological remission (RR), is the ultimate treatment goal in treatment of complex perianal fistula (cPAF) in Crohn’s disease (CD). In this study, we analysed cPAF disease characteristics and RR-related factors in a CD cohort.

Methods
Patients with CD (1999–2023) and MRI-confirmed cPAF (per AGA 2003 criteria, reviewed by 4 radiologists) were analyzed. Clinical remission (CR) was defined as no drainage under compression for ≥3 months, and RR as fibrotic fistula closure.

Results
Among 1688 CD patients, PAF prevalence was 24.7% (n=417), with 19% (n=79) classified as simple fistulas. Detailed analysis included 223 cPAF patients with sufficient follow-up. Male predominance was noted (65.5%), with a median CD diagnosis age of 28(IQR: 20) years and cPAF onset at 8(53) months. Median follow-up was 58(79) months. Isolated PAF occurred in 8.5%. Patients had a median of 2 fistulas, with ≥1 fistula in 51.6%. Common cPAF types were ISF (77%) and TSF (46%), with branching formation evident in 38.6%. Immunomodulator (IM) use was 94%, Anti-TNF+IM combination 87%, and multiple Anti-TNF exposure 35%. IFX was given to 31.8% at 5mg/8w and 51.9% at higher doses (up to 15mg/kg/4w).
CR was achieved in 71% and RR in 43.5% of patients following a stepwise treatment approach including antibiotics, IM, Anti-TNF dose escalation, and diverting stoma (Figure 1). In the RR group, cPAF onset after CD diagnosis, non-mucosal (B2-B3) involvement, and abscess-related low fistulas were more frequent, while multiple cPAF, branching formation, and TSF were more common in the non-RR group (Table 1). Time-dependent analyses showed better RR associated with cPAF onset after CD diagnosis (log-rank &lt;0.001), fewer fistulas (LR=0.035), abscess-related low fistulas (LR&lt;0.001), and early Anti-TNF initiation (&lt;0.008). Poor RR was linked to branched fistulas (LR=0.003), TSF (LR=0.042), and multiple Anti-TNF exposure (LR=0.017). The development of cPAF after CD diagnosis during follow-up, fistulas other than TSF, the absence multiple Anti-TNF exposure, and early initiation of Anti-TNF treatment were independently associated with better RR rates in multivariate analyses.

Conclusion
With a appropriate stepwise approach, including dose adjustments and stoma, RR can be achieved in 43.5% of cPAF patients. TSF-type fistulas are associated with poorer outcomes, while low perianal fistulas complicated by abscesses show better prognosis. Multiple Anti-TNF exposure predicts a poor response, whereas cPAF onset during follow-up and early Anti-TNF initiation are strongly associated with achieving RR.
P1342 Characteristics of the gut microbiota of patients with concomitant inflammatory bowel disease and psoriatic arthritis
Authors: De Francisco Garcia R M , Arboleya S , Queiro R , García-Pérez C , Gómez E , Pérez-Martínez I , Castaño-García A , Carballo-Folgoso L , Flórez-Díez P , Fernández-González E , Suárez A , González-Solares S , Gueimonde M , Riestra Menéndez S 
Published: January 2025

Abstract

Background
Inflammatory bowel disease (IBD) and psoriatic arthritis (PsA) are immune-mediated diseases (IMDs) that have been independently related to shifts in the gut microbiota. In this pilot study, we analyzed whether, in patients in whom both IMIDs coexist, the composition and function of the gut microbiota is different from when only one of the two IMDs exists.

Methods
Transversal observational study performed at a Spanish tertiary hospital. Ten patients with concomitant IBD and PsA (group A) were included. Two age, gender and disease duration matched control groups were also created, one with IBD-only patients (group B, n=20), and another with PsA-only patients (group C, n=20). Demographic and clinical characteristics were recorded. Stool samples were collected and the variable region V3–V4 of the bacterial 16S rRNA genes present in the feces was PCR-amplified and the resulting amplicons were sequenced on an Illumina NovaSeq 6000 instrument. Short chain fatty acids (SCFA) were analyzed by gas chromatography from the supernatants of the homogenized feces. Dietary assessment was registered by an online food frequency questionnaire specifically designed for intestinal disturbances; foods were transformed into nutrients and dietary compounds. For statistical analysis, ANOVA was used to compare the three groups (when the ANOVA was significant [p&lt;0.05], Bonferroni's test was used for post-hoc comparisons).

Results
Globally, the microbiota of the different study groups did not show major rearrangements, with alpha diversity not showing statistically significant differences between them. However, beta diversity analyses indicated that the microbiotas of groups C and B were statistically different, with group A occupying an intermediate position. A linear discriminant analysis of the effect size showed that group A was enriched in certain microorganisms such as Akkermansia, while group C was enriched in Bacteroides (Figure 1).
The quantification of the fecal levels of SCFA showed no statistical significant differences between the three groups. Moreover, no significant differences were observed regarding energy and nutrient intake between the assessed groups.

Conclusion
Our results suggest the existence of different gut microbiota profiles in subjects suffering from PsA or IDB, while patients with both conditions have an intermediate composition. These differences do not see to result from different dietary habits, since no differences in nutrient or energy intake between the groups were observed.
N01 Sexuality and IBD. Does it need to be talked about in IBD centres? Results of an anonymous survey at IBD-Patients, -Nurses und -Physicians (MD) in Germany (IBD-INTIM!)
Authors: Hartmann P , Zemke J , Fischer T , Knaus S , Dukwen H , Otto K ,   FA-CED e.V. - German IBD Nurse Association
Published: January 2025

Abstract

Background
Sexuality in Inflammatory bowel disease (IBD) is often a tabu topic. But do patients want to talk about it at all? How familiar are IBD Nurses and MD with this topic, will this routinely be addressed to IBD-patients during their consultations? This study attempted to determine the need for information and the willingness to talk about sexuality among patients, IBD nurses and MDs. The survey was carried out in an outpatient setting in Germany.

Methods
Each participant completed an anonymous questionnaire, limited to 2 MDs, 2 IBD nurses, 5 patients per site, in order to optain a broad opinion across Germany. All participants received an information sheet about the survey in advance. The completed questionnaire was sent to the evaluators in a sealed envelope. It was possible to complete the questions electronically, but this option was rarely used. Patients were selected randomly without taking into account the extent, duration and severity of the disease or the actual drug therapy.

Results
53 MD, 60 IBD nurses and 144 patients (Figure 1) in 39 sites answered the survey. Over half of patients in our cohort don't want to talk about sex if asked (52%). Out of those 48% who want to talk about the topic, do 62% not care who addresses that topic, 24% prefer the IBD nurse and 15% a MD. 93% of patients were never addressed to the topic in their IBD Centre. There was no connection between the wish to talk about sex and age (r = -.06, p = .460) nor between age groups (χ² (3)=0.81, p = .848) or between Crohn's disease (CD) and ulcerative colitis (UC) (χ² (1)=0.29, p = .588). The quality of sexual life does not necessarily appear to be affected, as average values are always relatively high and symptoms are low (Table 1). Nurses and MDs have sufficient knowledge about IBD and Sexuality: Nurses M=3.17/6 (SD = 1.13), MD M=3.44/6 (SD = 0.96). There is a significant connection between shame and knowledge (r = -.30, p = .023), meaning more knowledge, less shame and vice versa. 83% of MD, 90% of IBD Nurses would like (more) information material, most frequently print media (71% of MD) or guideline (83% of Nurses) to pass on to patients or self-training.

Conclusion
The quality of sexual life does not necessarily appear to be affected in our cohort. Sexuality beyond pregnancy and the desire to have children does not appear to be a major issue for IBD patients, 52% do not want to talk about it, even when the topic comes up during their consultations. There was no correlation between the desire to talk about sexuality based on gender, age, different age groups, or CD or UC. Further research with focus on individual aspects is necessary in order to be able to provide good advice to patients who want information.

References
none
N29 Inflammatory Bowel Disease advice lines: A Scoping Review
Authors: Hare N , Norton C , Irving P , Czuber-Dochan W 
Published: January 2025

Abstract

Background
Telephone or email advice lines offer a service that bridges primary and specialist care provision, supporting the needs of those living with an unpredictable disease course. This scoping review aimed to systematically synthesise published evidence with regards to Inflammatory Bowel Disease (IBD) advice line services and to identify gaps in research to inform further work.

Methods
A scoping review was undertaken in accordance with the patterns, advances, gaps, evidence and research (PAGER) framework1. Databases searched included CINAHL, PubMed and EMBASE. Inclusion/exclusion criteria were applied by two reviewers independently. Data were collected using a pre-defined matrix, from which the framework was applied as a means of systematically collating patterns, advances, gaps, evidence and research recommendations.

Results
17 full text publications and 22 abstracts published between 2006 – 2023 were included. Four overarching patterns were identified: advice lines as a complex intervention, drivers for advice line encounters, patient outcomes, and economic impact of advice lines.Advice lines are commonly a nurse-led service, facilitating on-demand specialist advice and clinical care. They function as a complex intervention within growing IBD services, and are currently accessed for a variety of clinical and non-clinical reasons, although flare management and medication advice remain a common driver for access. There are significantly increased costs to wider healthcare, associated with frequent users of IBD advice lines.

Conclusion
The current evidence landscape lacks empirical research supporting the clinical and economic effectiveness of advice lines. IBD advice lines are commonly a nurse-led service functioning as a complex intervention, supporting both administrative and clinical issues. They appear pivotal in preventing use of acute services and escalating or re-directing care including treatment, investigation and advice. Further research should focus on robust clinical and economic evaluation for patients and services, exploring patient experience of advice line services, including barriers and facilitators, and characterising those who do not currently access the service.

References
1.Bradbury-Jones C, Aveyard H, Herber OR, Isham L, Taylor J, O’Malley L. Scoping reviews: the PAGER framework for improving the quality of reporting. Int J Soc Res Methodol. 2022;25(4):457-470. doi:10.1080/13645579.2021.1899596
Developing a collaborative Dungeness crab larval monitoring network in the Salish Sea to provide long-term, fishery-relevant data
Authors: Buckner Emily V , Grossman Sarah K , Cook Claire , Brownlee Allison , Barber Julie S , Earle Heather , Becker Bonnie J , Bosley Katelyn , Harrington Neil , McDonald P Sean , Paul Blair , Homerding Margaret , Houle Katie , Galiotto Alexandra , Pantaleo Gianna , Paul Austin 
Published: January 2025

Abstract
Many natural resources are managed without essential, biologically relevant data. Fisheries are particularly susceptible to this reality and, thus, are vulnerable to environmental changes and disturbances, with both human livelihoods and the health of ecological systems at stake. Here, we explore how the Pacific Northwest Crab Research Group (PCRG) employs a collaborative, stakeholder-driven approach to generate the information needed to inform a data-poor, co-managed fishery, using the example of Dungeness crab Metacarcinus magister in the northeastern Pacific’s Salish Sea. We focus on the PCRG larval crab monitoring network as a multifaceted case study, which unites tribal, state, and federal governments, nongovernmental organizations, academic institutions, and local communities working to produce the first standardized continuous data set on Dungeness crab larval dynamics in the region. Highlighting the types of biological data collected, including spatial and temporal patterns of larval flux and larval size, we explore the application of novel data to fisheries management, as well as the network’s contribution to a diversity of educational opportunities and ability to leverage new research projects and collaborations. The success of PCRG’s larval crab monitoring network ultimately highlights the effectiveness of a cooperative, network-based approach in addressing fisheries management challenges and offers a viable model for managing data-poor systems worldwide.
Section 303(d) of the Clean Water Act: What does it mean for fisheries?
Authors: Kusnierz Paul C , Alford Brian , Pierce Ron , Tracy Bryn H , Jager Henriette I , Lomnicky Gregg 
Published: January 2025

ABSTRACT
The Clean Water Act (CWA) was passed by the United States Congress in 1972. It established regulations for the quality of discharges from point sources and a framework to assess water quality condition, identify what must be done for impaired waters to meet water quality standards, and work with stakeholders to improve water quality conditions. Section 303(d) of the CWA specifically outlines a framework for authorized states, territories, and tribes to identify polluted waters. It also requires plans be written that describe how water quality can be restored. Implementation of Section 303(d) can affect the condition of waterbodies as well as the fisheries that they support. In this paper we describe the 303(d) process and explain how fisheries professionals and the species they manage can benefit from the data produced through this process and the required public engagement. In addition, we provide two examples where involvement of fisheries professionals in the 303(d) process has resulted in both improved water quality and fisheries. Finally, we encourage fisheries professionals to become engaged in the 303(d) process to improve water quality and fisheries outcomes.
Surface deformation dynamics of Sierra Negra's 2018 eruption: insights from InSAR, optical flow and pixel offset tracking
Authors: Mohammadnia Mohammadhossein , Vajedian Sanaz , Mousavi Zahra , Aflaki Mahtab 
Published: January 2025

SUMMARY
Monitoring volcanic deformation is crucial for understanding volcanic behaviour, but challenges like limited global navigation satellite system (GNSS) coverage, infrequent synthetic aperture radar (SAR) data acquisitions, and coherence loss during eruptions complicate this task. Our study on the 2018 eruption of Sierra Negra utilizes Sentinel-1A/B images to track surface deformation patterns that revert to their initial state across three phases: before, during and after the eruption. We implemented an adaptive workflow using the shortest temporal baseline of consecutive SAR image pairs, including InSAR, optical flow and pixel offset tracking methods, to accurately capture surface displacement linked to the dynamics of the magma reservoir in the caldera and a nearby (sub-) horizontal dike. Results show that while the caldera subsided gradually over two months during lava flow (initially at a rate of several metres) until it began to uplift again, the northern region alternated between uplift and subsidence twice in the line-of-sight (LOS) direction. This pattern suggests repeated magma injections into the sub-horizontal dike sustained the lava flows from the northeastern fissure. The one-day difference between SAR images from ascending and descending tracks enabled us to estimate the underground magma transfer rate at approximately 60 m hr−1, which aligns with the magma migration trajectory indicated by seismic data. By integrating InSAR and offset tracking methods, we provide a comprehensive view of surface displacement throughout the volcanic eruption cycle.
Giant rhinolith in the left nasal cavity: a case report and literature review
Authors: Alabdulaal Maria R , Aljubran Hussain J , Alruwaili Sultan H , Subaih Abdulrahman T , Albahrani Hussain S , Almomen Ali 
Published: January 2025

Abstract
Giant rhinoliths are uncommon, mineralized concretions that usually develop around an intranasal foreign substance in the nasal canal. These lesions frequently cause respiratory problems, foul-smelling discharge, and nasal blockage. Clinical examination, endoscopy, and radiological imaging are used to make the diagnosis, and surgical removal is the only effective therapy. A giant rhinolith was discovered in a 42-year-old female patient with metastatic breast cancer came with nasal blockage. After 6 months, there were no complications or recurrences following the surgical removal of the calcified tumor. The significance of taking rhinoliths into account in individuals who have prolonged symptoms and unilateral nasal blockage is demonstrated by this case study. Consequently, early diagnosis and management are necessary to avoid potential complications and ensuring an excellent outcome.