bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-of-day discrepancy for the long-term surgical outcome of patients with aortic dissection
Authors: Dong Yi , Zhu Shen-Shan , Chen Liang-Wan , Luo Zeng-Rong 
Published: August 2023

Abstract

OBJECTIVES
It has been suggested that the time of day when cardiovascular surgery is performed may affect the surgery outcomes. This study investigated whether there was a difference in risk-adjusted mortality and morbidity outcomes between patients undergoing acute aortic dissection (AAD) during the day or the night.

METHODS
Consecutive patients who had undergone Stanford A AAD surgery were enrolled between 2016 and 2020. In the daytime group, surgery was performed between 08:00 and 20:00, and in the nighttime group between 20:00 and 8:00. The primary outcome was in-hospital overall mortality, and the secondary outcomes were overall mortality within a median follow-up time of 35.2 (17.0, 53.5) months and the occurrence of re-entry tears and major bleeding.

RESULTS
A total of 925 patients were enrolled. The primary outcome of in-hospital overall mortality did not differ significantly between patients who received daytime or nighttime surgery. Similarly, the secondary outcomes of overall mortality during the follow-up and incidence of re-entry tears and major bleeding did not differ significantly between the groups. Subgroup analysis was also performed according to the surgery type (modified triple-branched stent graft implantation or frozen elephant trunk implantation) and surgical approach (partial upper sternotomy or full median sternotomy) confirming that the time of surgery did not significantly influence the outcomes. Cox regression analysis showed that time from onset to admission (P = 0.036) and time from the onset to surgery (P = 0.045) were significant risk factors for increased mortality during follow-up.

CONCLUSIONS
The time of day when thoracotomy was performed did not significantly affect the clinical outcome and is therefore not a consideration for the improvement of outcome in Stanford A AAD patients.
Two faces of message repetition: audience favorability as a determinant of the explanatory capacities of processing fluency and message fatigue
Authors: So Jiyeon , Song Hyunjin 
Published: August 2023

Abstract
This study offers a critical test of two competing theoretical accounts of message repetition effects—processing fluency and message fatigue—which have yet to be examined together under a coherent framework. Furthermore, integrating research on metacognition and motivated processing, we propose audience favorability toward message advocacy as a crucial moderator in this dynamic. A repeated-exposure experiment (N = 845) involving five different messages about climate change mitigation was conducted. Multilevel moderated mediation analyses showed that audience favorability critically moderated the mediational effects of the two mechanisms: For favorable individuals, repeated exposure enhanced persuasion through increased fluency and decreased fatigue. In contrast, for unfavorable individuals, repeated exposure diminished persuasion via increased fatigue and decreased fluency. Collectively, this study demonstrates that message repetition does not have uniform effects on persuasion but rather its effects critically hinge on audience favorability and challenges the fundamental notion that fluency and fatigue necessarily increase with repetition.
Phenomenology of the Turing test: a Levinasian perspective
Authors: Lindia Matthew S 
Published: August 2023

Abstract
This article considers the Turing test as a problem of communication, particularly by asking how the language of artificial intelligence (AI) appears to human experience in comparison to the language of the Other. This question is approached through Levinas’ philosophy, by considering the possibility of AI as an absolute alterity, rather than reducing its alterity to the Same. This perspective diverges from traditional accounts of AI, which are more concerned with identifying structures of consciousness in the machine that are analogous to those evident in firsthand experience. This article asks how exactly AI appears to human consciousness, and whether this appearance precludes the appearance of AI as a thinking-being. In the final analysis, the author argues that AI diverges from Levinas’ understanding of alterity, which centers around the exteriority of the Other. The alterity of AI, in contrast, centers around anteriority, defined as the appearance of language's origin-in-itself.
Evaluation of deep learning-based deliverable VMAT plan generated by prototype software for automated planning for prostate cancer patients
Authors: Kadoya Noriyuki , Kimura Yuto , Tozuka Ryota , Tanaka Shohei , Arai Kazuhiro , Katsuta Yoshiyuki , Shimizu Hidetoshi , Sugai Yuto , Yamamoto Takaya , Umezawa Rei , Jingu Keiichi 
Published: August 2023

Abstract
This study aims to evaluate the dosimetric accuracy of a deep learning (DL)-based deliverable volumetric arc radiation therapy (VMAT) plan generated using DL-based automated planning assistant system (AIVOT, prototype version) for patients with prostate cancer. The VMAT data (cliDose) of 68 patients with prostate cancer treated with VMAT treatment (70–74 Gy/28–37 fr) at our hospital were used (n = 55 for training and n = 13 for testing). First, a HD-U-net-based 3D dose prediction model implemented in AIVOT was customized using the VMAT data. Thus, a predictive VMAT plan (preDose) comprising AIVOT that predicted the 3D doses was generated. Second, deliverable VMAT plans (deliDose) were created using AIVOT, the radiation treatment planning system Eclipse (version 15.6) and its vender-supplied objective functions. Finally, we compared these two estimated DL-based VMAT treatment plans—i.e. preDose and deliDose—with cliDose. The average absolute dose difference of all DVH parameters for the target tissue between cliDose and deliDose across all patients was 1.32 ± 1.35% (range: 0.04–6.21%), while that for all the organs at risks was 2.08 ± 2.79% (range: 0.00–15.4%). The deliDose was superior to the cliDose in all DVH parameters for bladder and rectum. The blinded plan scoring of deliDose and cliDose was 4.54 ± 0.50 and 5.0 ± 0.0, respectively (All plans scored ≥4 points, P = 0.03.) This study demonstrated that DL-based deliverable plan for prostate cancer achieved the clinically acceptable level. Thus, the AIVOT software exhibited a potential for automated planning with no intervention for patients with prostate cancer.
The War at Home: Photography, Political Violence, and Spectacle in the Russian Revolution of 1905
Authors: Morrissey Susan K 
Published: August 2023

Abstract
In early twentieth-century Russia, a disastrous war and social revolution shook the foundations of the imperial state, unleashing the press from censorship and demanding innovation in media coverage. At this very moment, new photographic technology was democratizing access and making high-quality reproductions affordable. This article explores how photography responded to and visualized the unprecedented political violence that engulfed Russia during the Revolution of 1905. Situating this “war at home” in a global context of early commercial and humanitarian photography of violence, it charts the emergence of distinctive visual regimes and spectatorial practices. As photographs made political violence visible within an unruly public sphere, they spotlighted some forms of violence and occluded others. Visual frames and narratives shaped new modes of representation and spectatorship, including regimes of commemoration, documentation, sensationalism, and forensics. This article opens with the most conventional photographic form, the studio portrait, and shows how it became imbricated with the political struggle and a forum for contesting the status of victim and martyr. The second section considers how the illustrated press crafted the terrorist bombing as a visual spectacle, using images with paratext to tell different kinds of stories. Shifting focus from the event to the body, the final section analyzes explicit photographs of the corpse. By exposing the violated body to the public gaze, these photographs posed a question fundamental to modernity, capitalism, and photography: who counts as fully human? This case study concludes with reflections on the categories of proximity and distance in the photography of violence. While the revolution was suppressed by 1907, it inaugurated a vibrant era of mass culture, capitalist consumption, and cultural pessimism, in which photography and film would play increasingly dominant roles.
A systematic review of the therapeutic effect of platelet-rich plasma for treating traumatic brain injury
Authors: Tangmi Djabo Eric Adrien , Mustapha Mubarak Jolayemi , Mbougo Voufo Jolyvette , Chitalu Mubanga Ndashi , Ibekwe Jonas Lotanna , Lim Yee Siew , Kweka Joyce Gasper , Ayantayo Temitayo , Eltingary Mazin M , Tunde Olobatoke , Emhemed Marwa SaedAli , Agada Nicaise Kpègnon , Bankole Nourou Dine Adeniran , Kyaruzi Victor Meza 
Published: August 2023

Abstract
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide and thus a significant public health concern. It can result in a range of physical, cognitive, and emotional impairments, which can significantly impact the quality of life of affected individuals and their families. Despite advances in the management of TBI, no effective treatment fully restores neurological function. Platelet-rich plasma (PRP) is a promising therapeutic approach for the treatment of TBI that has gained increasing attention in recent years. PRP is a blood product containing high concentration of platelets rich in growth factors and other bioactive molecules that can promote tissue repair and regeneration. PRP has been used in various clinical settings to accelerate healing and reduce inflammation, and there is growing evidence that it may have therapeutic benefits for TBI. This study seeks to gather evidence-based information on the therapeutic effect of PRP in the treatment of TBI. This protocol will follow the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis [PRISMA] guideline 2020. In this review, we determined four primary central databases as sources of information: PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trails. This Project was registered on the International Prospective Register of Systematic Reviews [PROSPERO]. Ethics and dissemination: Ethical approval for this study was not needed as we used alread y published studies to run this current study. Study findings will be published in journals and presented at conferences for broader dissemination. PROSPERO Registration N°: CRD42023426358.
RNA pseudouridine modification in plants
Authors: Niu Yanli , Liu Lingyun 
Published: August 2023

Abstract
Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models, the recent findings provide strong evidence for the critical role of pseudouridine in plants. Here, we review the current knowledge of pseudouridine in plant RNAs, including its synthesis, degradation, regulatory mechanisms, and functions. Moreover, we propose future areas of research on pseudouridine modification in plants.
In vitro antifungal susceptibility profile and genotypic characterization of clinical Aspergillus isolates in Eastern China on behalf of Eastern China Invasive Fungi Infection Group
Authors: Lin Huiping , Guo Jian , Li Yueting , Xiao Chenlu , Hu Liang , Chen Hui , Lu Xiuhai , Wu Wenjuan 
Published: August 2023

Abstract
Aspergillus species is a widespread environmental mould that can cause aspergillosis. The purpose of this study was to investigate the antifungal susceptibility profile and genotypic characterization of clinical Aspergillus isolates from different provinces in Eastern China. The data included the antifungal susceptibility distributions with eight common antifungal drugs, cyp51A gene mutations of triazole-resistant Aspergillus fumigatus sensu stricto, and the genotypic relationships among the A. fumigatus sensu stricto isolates based on microsatellite typing. A. fumigatus sensu lato was the most common clinical Aspergillus species (n = 252), followed by A. flavus (n = 169), A. terreus (n = 37), A. niger (n = 29), and A. nidulans (n = 4). The modal minimum effective concentration values of micafungin and anidulafungin were lower than those of caspofungin for all Aspergillus species. The in vitro efficacy of isavuconazole was similar to that of voriconazole against most Aspergillus species. Sequencing revealed cyp51A gene mutations TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A in four triazole-resistant A. fumigatus sensu stricto. Phylogenetic analyses using microsatellite markers of A. fumigatus sensu stricto revealed that 211 unique genotypes clustered into two clades. The data demonstrate the diversity of clinically relevant Aspergillus species in Eastern China. Routine antifungal susceptibility testing should be performed to monitor the antifungal resistance and guide clinical therapy.
A new variability pattern in GRS 1915+105 with NICER and Insight-HXMT observations
Authors: Shi Zhihong , Wu Qingwen , Yan Zhen , Lyu Bing , Liu Hao 
Published: August 2023

ABSTRACT
We explore the timing and spectral properties of GRS 1915+105 based on X-ray observations of NICER and Insight-HXMT during the long outburst from 2017 to 2021. We find a new class of variability in the rising stage of the outburst that differs from the formerly reported patterns of light curves. This new variability pattern, which we name class ψ, is characterized by several periodic mini pulses superposed on another longer periodic pulse. The periods are ∼130 and ∼10 s for the main pulses and mini pulses, respectively, based on the analysis of power spectrum density and step-wise filter correlation (SFC), where the SFC method has an advantage in finding the superimposed periodic components. The mini pulses become weak or disappear when the luminosity increases and the light curves change into the classical class κ. The class ψ shows a softer spectrum with lower count rates compared to the class κ during the main pulse. The new class ψ shows peculiar timing and spectral properties compared to those of classic class κ, which can help us to explore the class transition mechanism in GRS 1915+105.
Multimessenger emission from the accretion-induced collapse of white dwarfs
Authors: Longo Micchi Luís Felipe , Radice David , Chirenti Cecilia 
Published: August 2023

ABSTRACTWe present fully general relativistic 3D numerical simulations of accretion-induced collapse (AIC) of white dwarfs (WDs). We evolve three different WD models (non-rotating, rotating at 80 per cent and 99 per cent of the Keplerian mass shedding limit) that collapse due to electron capture. For each of these models, we provide a detailed analysis of their gravitational waves (GWs), neutrinos, and electromagnetic counterpart and discuss their detectability. Our results suggest that fast rotating AICs could be detectable up to a distance of 8 Mpc with third-generation GW observatories, and up to 1 Mpc with LIGO. AIC progenitors are expected to have large angular momentum due to their accretion history, which is a determining factor for their stronger GW emission compared to core-collapse supernovae (CCSNe). Regarding neutrino emission, we found no significant difference between AICs and CCSNe. In the electromagnetic spectrum, we find that AICs are two orders of magnitude fainter than type Ia supernovae. Our work places AICs as realistic targets for future multimessenger searches with third generation ground-based GW detectors.
Joining forces to understand what matters most: qualitative insights into the patient experience of outpatient rheumatology care
Authors: Bryant Madeleine J , Munt Rebecca , Black Rachel J , Reynolds Amy , Hill Catherine L 
Published: August 2023

AbstractObjectivePeople with rheumatic diseases are frequent, long-term attenders of health-care services. Their care experiences are central to improving services. The aim of this study was to explore real-world experiences and priorities of people attending outpatient rheumatology care and those of health-care professionals (HCPs) providing care.MethodsThis qualitative study consisted of five semi-structured focus groups. Participants included rheumatology outpatients (n = 16) of two tertiary teaching hospitals and HCPs (n = 14; rheumatologists, rheumatology trainees, physiotherapists, a specialty nurse and a pharmacist). Participants explored priorities when attending outpatient services, real experiences and aspirations for improving future care. Transcripts were coded using inductive and deductive thematic analysis.ResultsSeven key themes were identified: smooth flow of technical processes, care coordination, individualized care, information sharing, clinical excellence, patient empowerment and comprehensive care. The findings were aligned conceptually with quality standards in Australia and worldwide. Different sub-themes and prioritization of concerns emerged from patient and HCP subgroups. Highly prioritized themes for patients pertained to processes and technical aspects of care. HCPs focused on themes relating to non-technical aspects of service provision: information sharing, individualization of care, patient advocacy and empowerment.ConclusionThis study captured valuable insights into the current experience of outpatient rheumatology care from the perspective of patients and HCPs. It informs a collective understanding of differing and shared priorities, positives of current care and areas requiring change. Themes derived from the study data can be conceptualized in terms of the process, content and impact of care. Such domains can be measured longitudinally by routine implementation of validated patient-reported experience measures in rheumatology.
Simulating diffraction effects in heliospheric imagers
Authors: Tappin S J , Davies J A , Eyles C J 
Published: August 2023

Abstract
In this paper, we consider the modelling of diffracted stray light in heliospheric imagers. The emphasis is on the imagers proposed by RAL Space as part of the phase A/B1 study for ESA’s Vigil (formerly called Lagrange) L5 monitoring mission. In order to handle the extreme diffraction angles, a one-dimensional version of the PROPER diffraction modelling library has been developed. This is used to compute patterns at the lens aperture, and the standard two-dimensional version is then used to continue propagation to the sensor plane. The effects of key instrument and modelling parameters are analysed with a view to optimize accuracy of the modelling and the diffraction performance of the instrument.
Tofacitinib therapy in refractory inflammatory myositis: a retrospective cohort study of 41 patients
Authors: Beckett Madelaine , Tan Julia , Bonnardeaux Evelyne , Dutz Jan , Shojania Kamran , To Fergus , Obrzut Anthony , Aviña-Zubieta J , Huang Kun 
Published: August 2023

Abstract

Objectives
To evaluate the efficacy and safety of tofacitinib in treatment-refractory inflammatory myositis in a real-world clinical setting.

Methods
All patients with refractory inflammatory myositis treated with tofacitinib from a single urban centre in Vancouver, British Columbia, Canada, were included from June 2016 to December 2022. The medical records of these patients were retrospectively reviewed.

Results
A total of 41 patients were included, 23 with classic DM, 12 with amyopathic DM (ADM) and six with PM phenotype. The patients failed an average of four to five non-steroidal immunosuppressants before initiation of tofacitinib. In the classic DM and ADM group, tofacitinib offered clinically and statistically significant cutaneous improvement. In all myositis patients including the PM phenotype, no meaningful muscle strength response to tofacitinib was observed. 53.7% of the patients discontinued tofacitinib due to lack of benefit or death. Of the 19 patients who remained on tofacitinib at the conclusion of this study, tofacitinib demonstrated clinically and statistically significant improvement in cutaneous disease activity.

Conclusion
Tofacitinib appears to be highly effective in targeting cutaneous manifestations in classic DM and ADM; however, minimal benefit in muscle strength in the DM or PM phenotype were observed.
SPONTANEOUS CLOSURE OF FULL-THICKNESS MACULAR HOLE AFTER PARS PLANA VITRECTOMY FOR RETINAL DETACHMENT: EVIDENCE OF ELLIPSOID ZONE RESTORATION
Authors: Pellegrini Francesco , Fossataro Federica , Fossataro Claudia , Rizzo Clara , Rizzo Stanislao 
Published: August 2023

Purpose:
To describe a case of full-thickness macular hole (FTMH) occurred after pars plana vitrectomy for a macula-sparing rhegmatogenous retinal detachment, which showed a spontaneous closure associated with outer retinal layers restoration.

Methods:
Case report.

Results:
A pseudophakic 69-year-old man underwent pars plana vitrectomy for a macula-sparing superior rhegmatogenous retinal detachment in the right eye. Best-corrected visual acuity was 20/20 before surgery. Three weeks after treatment, the patient complained about visual impairment, and an FTMH was detected at fundus examination as well as confirmed by optical coherence tomography scan. The patient was scheduled for a repeated surgery, but FTMH spontaneously closed 18 days after its occurrence as demonstrated by optical coherence tomography showing only a point break of the ellipsoid zone and Verhoeff membrane. The subsequent macular optical coherence tomography scan showed a point-like irregularity at the Verhoeff membrane and regeneration of ellipsoid zone, associated with a progressive improvement in the best-corrected visual acuity. Forty days after the FTMH occurrence, all the retinal layers were completely restored with a complete clinical recovery.

Conclusion:
Full-thickness macular hole formation and closure after macula-sparing rhegmatogenous retinal detachment repair is a rare event that could be characterized by spontaneous and gradual anatomical restoration of the ellipsoid zone associated with visual acuity improvement, underlying the retinal physiology recovery.
Use of Chinese Herbal Medicine to Inhibit Podocyte Damage as Therapeutic Strategy for Membranous Nephropathy
Authors: Zhang Wei , Hu Anlan , Wang Juan , Wang Yudian , Yu Xiaoyong 
Published: August 2023

ABSTRACT
Membranous nephropathy (MN), one of the most common glomerular diseases, is a noninflammatory autoimmune podocyte disease. In the body, podocytes play an important role in maintaining the stability of the glomerular filtration barrier, and the degree of podocyte damage is a major determinant of MN prognosis because of the limited ability of podocytes to repair and regenerate. Although several therapeutic modalities for inhibiting podocyte damage are currently available, most lead to adverse, nonspecific systemic effects; therefore, newer drugs are necessary to target podocyte damage in MN. Traditional Chinese medicine (TCM) plays an important role in the treatment of primary MN in China. This study reviews the role of podocytes and the mechanisms of podocyte injury in MN glomeruli and summarizes the current status of complement-mediated therapy, the clinical efficacy of TCM in the treatment of primary MN, and the potential mechanisms regulating podocyte injury to support the development of new therapeutic strategies.