bluuebunny/crossref_metadata_2025_split huggingface dataset:
The devil is in the details: An analysis of the criteria for adequate reasoning in arbitral awards in Jordan
Authors: Alhasan Tariq K. 
Published: September 2023

AbstractArbitration has become a popular method for resolving disputes in Jordan due to its flexibility, confidentiality, and efficiency. However, the validity of an arbitration award depends on several factors, including the adequacy of the award's reasoning. This case report from Jordan highlights the importance of adequate reasoning in arbitral awards and the consequences of its absence. The report analyzes a recent court ruling that annulled an arbitration award due to the lack of reasoning and examines the criteria that arbitration jurisprudence has set for appropriate reasoning. The report concludes that an arbitration award without adequate reasoning is tainted by a flaw where the reasoning behind a decision is not provided or is insufficient, leading to its invalidity/annulment.
Flow cytometry analysis of protein expression using antibody‐derived tags followed by CITE‐Seq
Authors: Shi Xiaoshan , Fan Wei , Mehrpouyan Majid , Chen Yu , D'Cruz Louise M. , Widmann Stephanie J. , Tyznik Aaron J. 
Published: September 2023

AbstractCellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE‐Seq) is a single‐cell phenotyping method that uses antibody‐derived tags (ADTs) to quantitatively detect cell surface protein expression and generate transcriptomic data at the single‐cell level. Despite the increased popularity of this technique to study cellular heterogeneity and dynamics, detailed methods on how to choose ADT markers and ensuring reagent performance in biological relevant systems prior to sequencing is not available. Here we describe a novel and easy‐to‐use multiplex flow proxy assay in which multiple protein markers can be measured simultaneously using a combination of ADT reagents and dye‐oligo conjugates by flow cytometry. Using dye‐oligo conjugates with sequences complementary to the ADT reagents, we can achieve specific binding and evaluate protein marker expression in a multiplex way. This quality control assay is useful for guiding ADT marker choice and confirming protein expression prior to sequencing. Importantly, the labeled cells can be directly isolated based on the specific fluorescence from dye‐oligo conjugates using a flow cytometry cell sorter and processed for downstream single‐cell multiomics. Using this streamlined workflow, we sorted natural killer cells and T cells efficiently using only ADT and dye‐oligo reagents, avoiding the possibility of decreased marker resolution from co‐staining cells with ADT and fluorescent antibodies. This novel workflow provides a viable option for improving ADT marker choice and cell sorting efficiency, allowing subsequent CITE‐Seq.
Does personal relative deprivation mediate the relationship between passive social media use and beliefs in conspiracy theories? Cross‐sectional correlational and experimental evidence
Authors: Gkinopoulos Theofilos , Pagliaro Stefano , Pacilli Maria‐Giuseppina , Bilewicz Michal , Teresi Manuel , Ballone Chiara 
Published: September 2023

AbstractSocial media use occupies a prominent space in social sciences scholarship and beyond. However, the distinction between active and passive use of social media, although important in explaining a variety of users’ behaviours, has been overlooked in terms of its potential to predict key socially relevant outcomes like beliefs in conspiracy theories. In three studies (N = 1388, in total), we provide evidence on (a) the role of passive social media use in believing in conspiracy theories via personal relative deprivation; (b) the interaction effect between social media use and personal relative deprivation on beliefs in conspiracy theories. The results showed that passive social media use is linked to, and increases, beliefs in conspiracy theories and this relationship is partially mediated via increased personal relative deprivation (Studies 1 and 2). In Study 3, personal relative deprivation was also manipulated experimentally in the context of a ʻmoderation‐of‐process' design, yielding a significant interaction with social media use. The results are discussed in the light of their social and media psychological contribution and implications in the digital era, when misinformation often becomes prevalent.
Toward thin and stable anodes for practical lithium metal batteries: A review, strategies, and perspectives
Authors: Lee Jiyoung , Jeong Seung Hyun , Nam Jong Seok , Sagong Mingyu , Ahn Jaewan , Lim Haeseong , Kim Il‐Doo 
Published: September 2023

AbstractThe lithium metal battery (LMB) is a promising energy storage platform with a distinctively high energy density in theory, outperforming even those of conventional Li‐ion batteries. In practice, however, the actual achievable energy density of LMBs is significantly limited due to the Li metal anode (LMA) being too thick (50–250 μm), and there are difficulties with expanding the highly reactive Li metal into large‐format cells due to safety concerns. Therefore, the recent focus of LMB research is headed toward the development of a thin and stable LMA. However, as the thickness of Li anode decreases (≤20 μm) and the absolute size of the battery cell increases, interfacial reactions on the Li surface become more active, potentially leading to fatal thermal runaway. In this regard, there is still much demand for the development of novel manufacturing technologies to overcome this issue and produce thin and stable Li metal. Considering these things, in this review, we initially examine the fundamentals regarding the deployment of LMAs using a number of essential metrics. Then, we introduce recent strategies employed for designing thin and stable Li anodes including host matrix architecturing, interface stabilization, and other advanced modifications. Finally, we propose future directions for the realization of practical LMBs and their potential applications in various battery systems, encompassing Na, K, and Zn‐based batteries. We anticipate that ultra‐thin and ultra‐stable metal anodes would find widespread utilization in secondary battery applications with high‐power requirements.image
Improved real‐time force control for applying axial force to axially stiff members
Authors: Cho Chang Beck , Chae Yunbyeong , Park Minseok 
Published: September 2023

AbstractOne of the challenges in real‐time dynamic testing is effectively controlling axial forces for axially stiff members such as columns, walls, and base isolators. Axial force has a significant influence on structural strength and post‐yield behavior, thereby maintaining proper axial force boundary conditions is crucial for accurate seismic performance evaluation. To overcome this challenge, a displacement‐based force control method using the adaptive time series compensator (D‐ATS) was developed in the existing study, but this method requires additional sensors such as displacement transducers and accelerometers to ensure the accuracy of force control. In this study, a new real‐time force control method is introduced, which eliminates the need for additional sensors beyond the default sensors available in a typical servo‐hydraulic actuator. Newly developed modules are also provided, which can satisfactorily estimate the velocity and force change rate of actuator, while effectively mitigating oil‐column resonance. Experimental validation is conducted using lead rubber bearings (LRBs) subjected to axial force and lateral movements. The results demonstrate the exceptional performance of the new force control method, offering a convenient and cost‐effective approach for applying axial forces in real‐time dynamic testing.
Optimized blockchain network model for 6G cellular vehicle‐to‐everything communication
Authors: Bilgehan Bülent , Sabuncu Özlem 
Published: September 2023

AbstractRoad safety of electric cars has required large and fast data flow. The six‐generation (6G) networks that provide hyper‐speed, ultra‐reliable, and minimal delay meet the requirements. Data reliability can be supported with popular blockchain technology, which is still widely accepted as a decentralized data management system. This article used an optimum path with the highest signal‐to‐noise constraints for the proposed algorithms. The essential requirement of error‐free data transmission for high‐speed and large data has been successfully implemented. Three‐stage implementations are suggested. The edge computers at the partners are used as storage to resolve the first level. A C‐V2X network solution is used to resolve the second level of economic activity. A two‐stage optimization strategy is used to consider the last level of high network transaction levels. The results of the newly introduced optimization algorithms are simulated and contrasted with those of a traditional, time‐consuming step‐by‐step calculation method. The introduced algorithms tested with real‐time experimental signal‐to‐noise ratio (SNR) and bit error rate (BER) values, giving successful results.
Examining the indirect role of perceived normativeness in the association between collectivistic values and psychological control of Turkish mothers
Authors: Yavuz H. Melis , Tuncay Ipek , Ruffman Ted , Selcuk Bilge 
Published: September 2023

AbstractParental psychological control has previously been related to negative developmental outcomes. However, fewer studies examined the cultural factors associated with parental psychological control. Several studies suggested that psychological control is used more by mothers in collectivistic (as compared to individualistic) cultures yet did not examine the mother's personal endorsement of the cultural values. This approach ignores the widely reported findings showing within country heterogeneity. In this study, we examined maternal adherence to collectivistic values and their psychologically controlling behaviour directed towards their preschool children. We also examined the indirect role of perceived normativeness of the psychologically controlling behaviour in the association between adherence to collectivistic values and using psychologically controlling behaviours. We hypothesized that mothers who endorsed collectivistic values more would perceive psychologically controlling parenting as more normative and in turn would display more psychological control. To test our research question, we collected data from 318 Turkish mothers, who had at least one preschool‐aged child (child Mage = 59.46 months, SD = 9.23; range = 34–80 months; 160 males). The descriptive analyses are planned to be run in SPSS and path analyses in MPlus are planned for examining the hypothesized mediational model.
Ascaridia galli infection in chicken: Pathobiology and immunological orchestra
Authors: Shohana Nusrat Nowrin , Rony Sharmin Aqter , Ali Md. Haydar , Hossain Md. Shahadat , Labony Sharmin Shahid , Dey Anita Rani , Farjana Thahsin , Alam Mohammad Zahangir , Alim Md. Abdul , Anisuzzaman  
Published: September 2023

AbstractBackgroundAscaridia galli is the largest gut‐dwelling helminth of chickens, which confers adverse effects on meat and egg production; thus, on the animal protein supply and the economy. Both adult and immature parasites affect gut health, but larval stages play a major role in pathology.AimsHere, we present immunology and pathology of A. galli in chickens.Materials and MethodsLiteratures were surveyed through online platforms such as PubMed, Google Scholar and Researchgate.ResultsThe larvae cause excessive mucus production, damage to the intestinal gland, hemorrhage, anemia, diarrhea, and malnutrition. The adult worms can cause death by intestinal obstruction and intussusception. Although both cellular and humoral immunity are involved in fighting against ascariasis, the role of naturally acquired immunity is poorly defined. In cellular immunity, Th‐2 cytokines (IL‐4, IL‐5, IL‐9, and IL‐13), goblet cells (mucin), gut‐associated lymphoid tissues, CD8α+ intraepithelial cells, TCRγδ + T cells, and TGF‐β4 form a protective band. Type 2 immunity provides protection by forming a network of endogenous damage‐associated molecular patterns, chitin, and parasitic antigens. Among antibodies, IgY is the most prominent in chickens and provides temporary humoral protection. During parasitic infection, infiltration of various immune cells is evident, especially in the intestinal epithelium, lamina propria, and crypts of the duodenum and jejunum. In chickens older than 12 weeks, gradual reduction of worm burden is more successful than the younger birds. Female chickens exert a short‐lived but higher level of protection by passing IgY to chicks in the form of egg yolk antibodies. In laying conditions, immunity differs between breeds. This review provides an overview of the silent but inevitable pathological changes induced by A. galli and the interaction of host immunity with the parasite.
The clinical and immunological characteristics of COVID‐19 patients with delayed SARS‐CoV‐2 virus clearance
Authors: Wang Jinsong , Li Debao , Tang Bo , Sun Xuemin , Shi Wenjiong , Li Hao , Zhang Zhenhua , Wu Yuzhang , Zhang Yi , Qiao Qinghua 
Published: September 2023

AbstractBackgroundThe outbreak of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a great threat to human health. Some severe COVID‐19 patients still carried detectable levels of SARS‐CoV‐2 even after prolonged intensive care unit treatment. However, the immunological features of these COVID‐19 patients with delayed virus clearance (CDVC) are still unclear.MethodsWe retrospectively reviewed the clinical and immunological data of 13 CDVC cases, who were admitted into one hospital in Wuhan from February to April 2020. These data were also compared to those of perished (n = 9) and recovered (n = 52) cases. The expression of the exhaustion marker PD‐1 on circulating T cells of these patients was measured by flow cytometry.ResultsHigh levels of serum interleukin‐6 (IL‐6), IL‐1β, IL‐8, as well as other inflammatory mediators, were seen in CDVC cases. Severe lymphopenia was observed in CDVC patients with the counts of total lymphocytes (0.9 × 109/L), CD4+ T cells (0.35 × 109/L), and CD8+ T cells (0.28 × 109/L) below their corresponding lower limits of normal range. Similar to the perished group, CDVC cases have higher percentages of CD25+Foxp3+ regulatory T cells (Treg) in circulation. Moreover, enhanced expression of the exhaustion marker PD‐1 on CCR7−CD45RA+ effector, CCR7+CD45RA− central memory, and CCR7−CD45RA− effector memory CD4+ and CD8+ T cells were also observed in CDVC cases.ConclusionCDVC patients still have SARS‐CoV‐2 and these cases manifest with severe clinical symptoms due to persistent inflammation. Augmentation of the frequency of circulating Treg, severe lymphopenia, and functional exhaustion of T cells might lead to inefficient clearance of SARS‐CoV‐2. Therefore, enhancing lymphocyte counts and reversing T‐cell exhaustion might be key methods to boost immune responses and eliminate SARS‐CoV‐2 in CDVC patients.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study
Authors: Danto Spencer I. , Tsamandouras Nikolaos , Reddy Padmalatha , Gilbert Steven , Mancuso Jessica , Page Karen , Peeva Elena , Vincent Michael S. , Beebe Jean S. 
Published: September 2023

AbstractPF‐06817024 is a high affinity, humanized antibody that binds interleukin‐33, a proinflammatory type 2 cytokine, and thereby has the potential to inhibit downstream type 2 inflammation. This Phase 1, randomized, placebo‐controlled study was conducted in 3 parts to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and pharmacodynamics of escalating single and limited repeat PF‐06817024 doses in healthy participants (Part 1), a single dose of PF‐06817024 in participants with chronic rhinosinusitis with nasal polyps (Part 2), and repeat doses of PF‐06817024 in participants with moderate to severe atopic dermatitis (atoptic dermatitis; Part 3). PF‐06817024 was generally well tolerated in all participant populations. Most participants experienced a treatment‐emergent adverse event (healthy participants, 78.4% and 100%; participants with chronic rhinosinusitis with nasal polyps, 90.9% and 88.9%; and participants with atoptic dermatitis, 60.0% and 62.5% in the PF‐06817024 and placebo groups, respectively). No substantial deviations from dose proportionality were observed for single intravenous doses of 10‐1000 mg, indicating linear PK in healthy participants. Mean terminal half‐life ranged from 83 to 94 days after single intravenous administration in healthy participants and was similar to that observed after administration in the studied patient populations. Incidences of antidrug antibodies in the studied populations were 10.8%, 9.1%, and 5.0% for healthy participants, participants with chronic rhinosinusitis with nasal polyps, and participants with atoptic dermatitis, respectively. In addition, dose‐dependent increases were observed in total serum interleukin‐33 levels of treated participants, indicating target engagement. Overall, the PK and safety profile of PF‐06817024 supports further investigation of the drug as a potential treatment for allergic diseases.
Subcategorization of Perineural Invasion Stratifies Oral Cavity Squamous Cell Carcinoma Prognosis
Authors: Fung Nicholas , Fleseriu Cara M. , Harley Randall J. , Khan Nayel I. , Kim Seungwon 
Published: September 2023

ObjectiveTo evaluate whether subcategorization of perineural invasion (PNI) improves the prognostic resolution of the American Joint Committee on Cancer, Eighth Edition (AJCC8) staging system in oral cavity squamous cell carcinoma (OCSCC).MethodsOCSCC tumor specimens from patients seen at a tertiary care institution who underwent primary surgical resection between January 2019 and June 2021 were sorted into four PNI categories: negative, intratumoral, peripheral, and extratumoral. The prognostic effect of these PNI categories were assessed through Kaplan–Meier, Cox regression, and log‐rank testing using recurrence‐free survival (RFS) and overall survival (OS) as primary and secondary outcomes respectively.ResultsA total of 158 patients were examined. The median follow‐up time was 21 months. PNI subcategorization further stratified RFS (p = 0.007) and OS (p = 0.002). Extratumoral PNI was associated with a 4.5‐fold increase in recurrence risk (adjusted hazards ratio [aHR]: 4.53; 95% confidence interval [CI]: 1.1–18.66) and worse OS when compared with PNI negative disease (aHR: 5.71; 95% CI: 1.0–32.67). Peripheral PNI was associated with worse OS (aHR: 5.7; 95% CI: 1.35–24.08) but not worse RFS (p = 0.18) when compared with PNI negative disease. Interestingly, intratumoral PNI was not associated with significant differences in RFS (p = 0.087) or OS (p = 0.22) when compared with PNI negative disease.ConclusionsSubcategorization of OCSCC tumors into extratumoral, peripheral, and intratumoral PNI stratifies RFS and OS when compared with patients with PNI negative disease in an incremental fashion. This pilot study suggests that there may be added benefit in subcategorization of PNI in the prognostic evaluation of OCSCC.Level of Evidence4 Laryngoscope, 134:1656–1662, 2024
Optical Flow Analysis of Paralaryngeal Muscle Movement
Authors: Morrison Robert A. , Fetzer David T. , Patterson‐Lachowicz Amber , McDowell Sarah , Smeltzer Julianna C. , Mau Ted , Shembel Adrianna C. 
Published: September 2023

ObjectivesThe paralaryngeal muscles are thought to be hyperfunctional with phonation in patients with primary muscle tension dysphonia (pMTD). However, objective, quantitative tools to assess paralaryngeal movement patterns lack. The objectives of this study were to (1) validate the use of optical flow to characterize paralaryngeal movement patterns with phonation, (2) characterize phonatory optical flow velocities and variability of the paralaryngeal muscles before and after a vocal load challenge, and (3) compare phonatory optical flow measures to standard laryngoscopic, acoustic, and self‐perceptual assessments.MethodsPhonatory movement velocities and variability of the paralaryngeal muscles at vocal onsets and offsets were quantified from ultrasound videos and optical flow methods across 42 subjects with and without a diagnosis of pMTD, before and after a vocal load challenge. Severity of laryngoscopic mediolateral supraglottic compression, acoustic perturbation, and ratings of vocal effort and discomfort were also obtained at both time points.ResultsThere were no significant differences in optical flow measures of the paralaryngeal muscles with phonation between patients with pMTD and controls. Patients with pMTD had significantly more supraglottic compression, higher acoustic perturbations, and higher vocal effort and vocal tract discomfort ratings. Vocal load had a significant effect on vocal effort and discomfort but not on supraglottic compression, acoustics, or optical flow measures of the paralaryngeal muscles.ConclusionOptical flow methods can be used to study paralaryngeal muscle movement velocity and variability patterns during vocal productions, although the role of the paralaryngeal in pMTD diagnostics (e.g., vocal hyperfunction) remains suspect.Level of Evidence2 Laryngoscope, 134:1792–1801, 2024
Cetacean‐mediated vertical nitrogen transport in the oceanic realm
Authors: Woodstock Matthew S. , Kiszka Jeremy J. , Ramírez‐León M. Rafael , Sutton Tracey T. , Fennel Katja , Wang Bin , Zhang Yuying 
Published: September 2023

AbstractIn natural systems, animal‐mediated nutrient transport can be a major driver of primary productivity, but the role of marine megafauna such as cetaceans in mediating the transfer and recycling of nutrients has been overlooked. Here, we developed a spatially resolved, stochastic, nutrient‐transport model for cetaceans in the oceanic Gulf of Mexico using species−specific foraging depths, distributions, and diets. An estimated 6.4 × 108 mmol N d−1, or 0.06 mt N yr−1 ind−1, is transported to the surface from depths below 100 m by the 19 cetacean species that occur in the oceanic Gulf of Mexico; 75% of this transport occurs seaward of the continental slope, but the per area transported nitrogen is greater on the continental slope (200–1000 m) than in the ocean basin. Benthos to surface transport comprised 6.0 × 107 mmol N d−1 and was much more common on the continental slope than the open basin. Compared to an existing physical‐biogeochemical model, the transported nutrients add 8% N d−1 to the estimated ammonium concentration above the nutricline and could add 16% N d−1 to the surface ammonium concentration if expelled nutrients remain at the surface. Through feeding on diel vertical migrants, cetaceans retain an additional 2.7 × 107 mmol N d−1 in the surface waters that would otherwise return to depth via downward diel vertical migration. Cetaceans contribute to nutrient movements and recycling in the oceanic Gulf of Mexico, and may provide one of the few allochthonous sources of nutrients for primary producers in oligotrophic ecosystems.