bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengetahuan, Sikap, dan Perilaku Terhadap Pengelolaan Limbah Bahan Kimia di Laboratorium Pada Siswa SMK
Authors: Sulistiyorini Desy , Purnamasari Eka Rokhmiati Wahyu , Dalimunthe Lesnasari 
Published: June 2023

The existence of activities in the laboratory becomes important for students to conduct experiments or research, and thus, improve their skills and abilities. However, the use of chemical and biological materials in the laboratory will certainly produce chemical and biological waste. The waste generated is potentially hazardous to health and can pollute or damage the environment either directly or indirectly. It is undeniable that laboratory activities can produce various types of waste, such as liquid and solid waste. This study aims to find out what is related to waste management in a private vocational high schools in the city of Bogor. The results showed that there was no relationship between the variables of gender (p value 1.000), training (p value 0.354), knowledge (p value 1.000) and attitudes (p value 0.472) of respondents to the behavior of laboratory waste management. In conclusion, there is no correlation between waste management practices in schools and knowledge, attitudes, student gender, or training experience. To increase student knowledge and awareness about chemical waste laboratories, however, participation in chemical waste laboratory management training is required of students.
Faktor Risiko Sanitasi Lingkungan terhadap Kejadian Stunting pada Balita di Indonesia : Literatur Review
Authors: Lisdeni Rahmi , Hartono Budi 
Published: June 2023

Stunting in toddlers is a global issue, according to WHO, 2022 that report there are 149,2 million toddlers who suffer from stunting. The research method is systematic literature review. The aim of the study is to look at the relationship between STBM theory, personal hygiene, and diarrhea with the incidence of stunting in toddlers. Based on the results of the study that in general there is a significant relationship between environmental sanitation variables and the incidence of stunting in toddlers. The results based on the specific research objectives found that the CTPS variable had a significant relationship with the incidence of stunting in toddlers, namely the research by Maudy Risma Slodia, et al, 2022 and Yuliani Soerachmad,et al, 2019. Variables of clean water facilities that are significantly related to the incidence of stunting in toddlers are research by Maudy Risma Slodia, et al 2022, Zairinayati, et al, 2019 and Inamah,et al, 2021. Conclusion : The environmental sanitation variables that affect stunting are CTPS, household waste protection, household rubbish protection, household drinking water and food security, toilet ownership facilities, incidence of diarrhea, availilability of clean water facilities, etc. Suggestion : expected that this research will become input for the community and health workers to control risk factors for environmental sanitation in order to reduce stunting in Indonesia.
METODE PELAKSANAAN LAPIS PERKERASAN AC – BC PADA PENINGKATAN JALAN POROS WAKURU, KEC. TONGKUNO, KAB. MUNA (Studi Kasus: Jalan poros Wakuru Kec. Tongkuno Kab. Muna)
Authors: Sahidin Muhammad , Nasrul Nasrul , Arsyad La Ode Muhammad Nurrakhmad 
Published: June 2023

Jalan raya adalah jalur-jalur tanah di atas permukaan bumi yang di buat manusia dengan bentuk, ukuran-ukuran dan jenis konstruksinya sehingga dapat digunakan untuk menyalurkan lalu lintas orang, hewan dan kendaraan yang mengangkut barang dari suatu tempat ke tempat lainnya dengan mudah dan cepat. Untuk perencanaan jalan raya yang baik, bentuk geometriknya harus ditetapkan sedemikian rupa sehingga jalan yang bersangkutan dapat memberikan pelayanaan yang optimal ke pada lalu lintas sesuai dengan fungsinya, sebab tujuan akhir dari perencanaan geometric ini adalah menghasilkan infrastruktur yang aman, efisiensi pelayanan arus lalu lintas dan memaksimalkan ratio tingkat penggunaan biaya juga memberikan rasa aman dan nyaman kepada pengguna jalan. Penelitian ini merupakan studi penelitian di lapangan yang bertujuan Untuk mengetahui apakah metode pelaksanaan pekerjaan AC – BC (Asphalt Concrete – Binder Course) pada proyek peningkatan jalan poros Wakuru, Kec. Tongkuno, Kab. Muna sudah sesuai dengan spesifikasi umum binamarga 2018. Bedasarkan hasil penelitian menunjukan tahapan pekerjaan lapis permukaan AC-BC pada proyek peningkatan jalan poros Wakuru Kec.Tongkuno Kab. Muna yaitu pembersihan badan jalan, penyiraman prime coat, pengangkutan material, penghamparan, pemadatan, danpengujian core drill di lapangan. Jadi metode pelaksaan pekerjaan lapis permukaan AC-BC pada proyek peningkatan jalan poros Wakuru Kec. Tongkuno Kab. Muna tidak memenuhi standar Spesifikasi Bina Marga 2018.
Perencanaan Geometrik Jalan Raya Ruas Pohara -Andepali
Authors: Anggara Muh. Ariyan Sukri , Sarita Umran , Mangiri Aloysius A. Prima 
Published: June 2023

Seperti halnya kondisi geometrik eksisting ruas jalan poros pohara- andepali, dimana sebagai akses altermatif dan waktu tempuh relatif cepat yang menghubungkan bandar udara haluoleo dengan kabupaten konawe utara, kabupaten konawe serta kabupaten kolaka timur perlu memperhatikan kondisi geometrik agar keamanan maupun kenyamanan kendaraan selama berkendara pada ruas ini sedapat mungkin tercipta. Berdasarkan analisis actual speed kecepatan rencana yakni 50 km/jam dimana jari minimum lengkung horizontal minimum R = 80 meter dan pada ruas ini terdapat 19 lengkung horizontal yang tidak memenuhi. Jadi, besarnya biaya yang diperlukan untuk pekerjaan perencanaan geometrik jalan raya dengan panjang jalan sejauh + 1,95 Km. Memerlukan total anggaran Rp 2.567.228.000 (Dua milliar lima ratus enam puluh tujuh juta dua ratus dua puluh delapan ribu rupiah).
Metode Pelaksanan Pekerjaan Pier Jembatan Teluk Kendari (Studi Kasus: Pier 4 pada Pembangunan Jembatan Teluk Kendari)
Authors: Fredianto Heru , Mursidi Baso , Alhas Muh. Rizal 
Published: June 2023

Penelitian ini menjelaskan pelaksanaan pekerjaan pier 4 Jembatan Teluk Kendari, agar dapat mengetahui detailing pekerjaan pier, mengetahui volume besi dan beton yang dibutuhkan pada pekerjaan pier. Pekerjaan ini menggunakan metode pondasi dalam yaitu bore pile. Hasil penelitian ini menunjukan bahwa pekerjaan pier 4 jembatan teluk anjang ini menggunakan bore pile berdiameter 1,5 meter sebanyak 15 tiang dan memiliki kedalaman mencapai 30 meter. Lalu pada kolom pier berbentuk gawang memiliki 2 kolom dan ringginya 5,83 meter serta lebarnya 2 meter, lalu membutuhkan beton ready mix 69,96 m³. Diatas kolom pier terdapat pier head yang panjangnya 20 meter dan lebar atas 2,25 meter serta lebar bawah 4,25 meter dan membutuhkan beton ready mix sebanyak 195 m³.
EVALUASI TINGKAT KERUSAKAN JALAN PADA RUAS JALAN PAELANGKUTA KOTA RAHA KABUPATEN MUNA
Authors: Ifantri Wa Ode , Ahmad Siti Nurjanah , Nuhun Ridwansyah 
Published: June 2023

Ruas jalan Paelangkuta Kota Raha Kabupaten Muna. Panjang jalannya ± 1 km, lebar perkerasan 7,8 m, dengan curah hujan di daerah tersebut cukup tinggi. Kerusakan yang terjadi di jalan ini mulai dari retak-retak, kerusakan pada permukaan perkerasan, dan berlubang.. Tujuan dari penelitian Jalan Paelangkuta adalah untuk menganalisis jenis tingkat kerusakan lapis permukaan dan memberikan solusi penanggulangannya. Metode analisis yang digunakan adalah metode Surface Distress Indeks (SDI). Hasil penelitian dari perhitungan adalah persentase tingkat kerusakan yang terdapat pada jalan tersebut.hasil dari penelitian ini adalah tingkat kerusakan dimana Jalan Paelangkuta persentase kerusakan dengan nilai SDI beberapa segmen 0% dengan kondisi baik dan di beberapa segmen lainnya 30% dengan kondisi baik dan di beberapa segmen lainnya 75% dengan kondisi sedang. Dengan cara penangannya untuk retak buaya yaitu lapisan tambahan, retak memanjang, yaitu perbaikan retakan didasarkan pada ukuran dan tingkat kerusakan dan lubang yaitu penaambalan diseluruh kedalaman.
PERHITUNGAN RENCANA ANGGARAN BIAYA ( RAB ) PADA RUMAH LANTAI 2 TYPE 140
Authors: Rismon Rismon , Mursidi Baso , Mustika Wayan , Arsyad La Ode Muhamad Nurrakhmad , Sulha Sulha , Rustan Fathur Rahman 
Published: June 2023

Sebagian besar masyarakat di Kota Kendari khususnya daerah pedesaan ketika akan membuat hunian sangat jarang memperhitungkan Rencana Anggaran Biaya (RAB) berdasarkan SNI 2016, hanya berdasarkan pengalaman pekerja atau tukang bangunan. Dengan adanya hal tersebut, penelitian ini bertujuan untuk menghitung berapa Rencana Anggaran Biaya (RAB) untuk rumah tipe 140 di Kota Kendari Provinsi Sulawesi Tenggara. Data yang akan diteliti adalah rumah tipe 140 di Kota Kendari Provinsi Sulawesi Tenggara. Metode RAB menggunakan SNI 2016 yang diawali dengan mempersiapkan daftar harga bangunan, daftar harga satuan upah, menghitung volume dari setiap jenis pekerjaan, menganalisa harga satuan dari setiap jenis pekerjaan dan membuat rekapitulasi, serta digunakan beberapa data antara lain Gambar Rencana, Satuan Harga Barang dan Jasa (SHBJ) dan Peraturan Mentri Pekerjaan Umum dan Perumahan Rakyat No. 28/PRT/M/2016. Berdasarkan hasil analisa dan perhitungan yang telah dilakukan, maka diperoleh total biaya yang dibutuhkan untuk membangun rumah lantai dua tipe 140 di Kota Kendari sebesar Rp. 362,090,100.00.
ANALISIS PRODUKTIVITAS ALAT BERAT PEKERJAAN LAPIS PONDASI ATAS (LPA) (Studi Kasus Jalan Poros Ruas Bungi-Sora Wolio Kota Bau-Bau)
Authors: Adityawan Muh. Handy Dwi , Minmahddun Anafi , Layori Layori 
Published: June 2023

Untuk memastikan progress pelaksanaan pekerjaan suatu proyek dapat berjalan sesuai dengan jadwal dan anggaran yang telah ditetapkan. Perlu dilakukan analisis produktivitas alat berat pada pekerjaan lapis pondasi atas (LPA) pada pekerjaan jalan. Paper ini bertujuan untuk menganalisis produktivitas alat berat pada pekerjaan LPA jalan ruas Bungi-Sora Wolio Kota Baubau. Dari hasil analisis diperoleh produktivitas dump truck, motor grader, vibrator roller masing-masing sebesar 40 m3/hari, 804.57 m3/hari dan 288 m3/hari. Produktivitas alat berat terbesar adalah motor grader, dengan durasi pekerjaan LPA dapat diselesaikan selama tiga hari. Untuk memenuhi durasi pekerjaan tiga hari maka dibutuhkan 14 unit dump truck dan 2 unit vibrator roller. Berdasarkan hasil pengamatan kondisi aktual di lapangan diketahui bahwa pekerjaan LPA diselesaikan selama 6 hari. Hal ini dikarenakan jumlah alat berat di lapangan lebih sedikit dibandingkan jumlah kebutuhan alat berat berat hasil analisis.
PENYELENGGARAAN JENAZAH MUSLIM DI SITUASI NORMAL DAN PANDEMI COVID-19
Authors: Ahmad Gunaldi 
Published: June 2023

This study is titled The Implementation of Muslim Bodies in Normal Situations and the Covid 19 Pandemic. If Muslims witness other Muslims in a situation of near death or ihtidar should do the following: Recite the next sentence of the shahada confronting the person nearing death towards the Qibla.Â Â Then when he dies, close the eyes of the body. Then immediately bathed, prayed, and buried. This study found that specifically the Covid-19 pandemic since 2020 until now has brought a very large death toll around the world, so the handling of Covid-19 bodies also has a different procedure. This research generally explains that the management of bodies exposed to Covid-19, especially in bathing and converting, refining and burial processes is not much different from the process of organizing Muslim bodies in general. The reform must be carried out in accordance with medical protocol and carried out by the authorities, keeping in mind the provisions of sharia. As for mashing and burying is done as usual while keeping from being exposed to Covid 19. This research was conducted with qualitative research, inductive data collection. The primary sources are books, and journals.
Observational and genetic evidence support a relationship between cardiac autonomic function and blood pressure
Authors: Chen Zekai , Wang Siqi , He Zhen , Tegegne Balewgizie S. , van Roon Arie M. , Holtjer Judith C. S. , van der Harst Pim , Snieder Harold , Thio Chris H. L. 
Published: June 2023

BackgroundIt is unclear how cardiac autonomic function, as indicated by heart rate (HR), heart rate variability (HRV), HR increase during exercise, and HR recovery after exercise, is related to blood pressure (BP). We aimed to examine the observational and genetic evidence for a potential causal effect of these HR(V) traits on BP.MethodsWe performed multivariable adjusted linear regression using Lifelines and UK Biobank cohorts to investigate the relationship between HR(V) traits and BP. Linkage disequilibrium score regression was conducted to examine genetic correlations. We used two-sample Mendelian randomization (2SMR) to examine potential causal relations between HR(V) traits and BP.ResultsObservational analyses showed negative associations of all HR(V) traits with BP, except for HR, which was positively associated. Genetic correlations were directionally consistent with the observational associations, but most significant genetic correlations between HR(V) traits and BP were limited to diastolic blood pressure (DBP). 2SMR analyses suggested a potentially causal relationship between HR(V) traits and DBP but not systolic blood pressure (SBP). No reverse effect of BP on HR(V) traits was found. One standard deviation (SD) unit increase in HR was associated with a 1.82 mmHg elevation of DBP. In contrast, one ln(ms) unit increase of the root mean square of the successive differences (RMSSD) and corrected RMSSD (RMSSDc), decreased DBP by 1.79 and 1.83 mmHg, respectively. For HR increase and HR recovery at 50 s, every additional SD increase was associated with a lower DBP by 2.05 and 1.47 mmHg, respectively. Results of secondary analyses with pulse pressure as outcome were inconsistent between observational and 2SMR analyses, as well as between HR(V) traits, and therefore inconclusive.ConclusionBoth observational and genetic evidence show strong associations between indices of cardiac autonomic function and DBP, suggesting that a larger relative contribution of the sympathetic versus the parasympathetic nervous system to cardiac function may cause elevated DBP.
Intellectual Humility and Self-Censorship in Higher Education; a thematic analysis
Authors: Godfrey Hayden 
Published: June 2023

IntroductionThis article explores whether social science lecturers and postgraduate students perceive their experiences of university as supporting intellectual humility – a concept representing a disposition to rigorously consider opposing ideas to beliefs held in order to confirm the positive epistemic status (or truth) of ones’ own beliefs.MethodsForty participants, consisting of twenty lecturers and twenty postgraduate students from the United Kingdom, took part in semi-structured interviews. The focus of these interviews was to explore whether their experiences in higher education align with the virtue of ‘intellectual humility’.ResultsThrough a thematic analysis, results showed that experiences of both lecturers and students did not support the traits of intellectual humility.DiscussionSuggestions for future research are made. The themes identified in this study could be used as a framework for investigating differing contexts of higher education in terms of their reflection of intellectual humility. Further, suggestions for how intellectual humility can be practically facilitated in higher education are made.
Season and temperature do not affect cumulative live birth rate and time to live birth in in vitro fertilization
Authors: Du Mingze , Zhang Junwei , Wei Zhancai , Li Li , Liu Xinmi , Liu Manman , Wang Xingling , Guan Yichun 
Published: June 2023

ObjectiveTo explore whether season and temperature on oocyte retrieval day affect the cumulative live birth rate and time to live birth.MethodsThis was a retrospective cohort study. A total of 14420 oocyte retrieval cycles from October 2015 to September 2019. According to the date of oocyte retrieval, the patients were divided into four groups (Spring(n=3634);Summer(n=4414); Autumn(n=3706); Winter(n=2666)). The primary outcome measures were cumulative live birth rate and time to live birth. The secondary outcome measures included the number of oocytes retrieved, number of 2PN, number of available embryos and number of high-quality embryos.ResultsThe number of oocytes retrieved was similar among the groups. Other outcomes, including the number of 2PN (P=0.02), number of available embryos (p=0.04), and number of high-quality embryos (p&lt;0.01) were different among the groups. The quality of embryos in summer was relatively poor. There were no differences between the four groups in terms of cumulative live birth rate (P=0.17) or time to live birth (P=0.08). After adjusting for confounding factors by binary logistic regression, temperature (P=0.80), season (P=0.47) and duration of sunshine(P=0.46) had no effect on cumulative live births. Only maternal age (P&lt;0.01) and basal FSH (P&lt;0.01) had an effect on cumulative live births. Cox regression analysis suggested no effect of season(P=0.18) and temperature(P=0.89) on time to live birth. Maternal age did have an effect on time to live birth (P&lt;0.01).ConclusionAlthough season has an effect on the embryo, there was no evidence that season or temperature affect the cumulative live birth rate or time to live birth. It is not necessary to select a specific season when preparing for IVF.
Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome
Authors: Ueki Yoko , Takimoto-Ito Riko , Saito Megumu K. , Tanizaki Hideaki , Kambe Naotomo 
Published: June 2023

IntroductionBlau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by a mutation in the NOD2 gene. It is characterized by a clinical trial of granulomatous dermatitis, arthritis, and uveitis. Tofacitinib is a pan Janus kinase (JAK) inhibitor used for treatment of Blau syndrome and idiopathic sarcoidosis. Here, we evaluated its effect on inflammatory pathways associated with Blau syndrome. The effect of tofacitinib on downstream pathways regulated by mutant NOD2 was analyzed using luciferase assays with overexpression of NOD2 mutants.MethodsThe effect of tofacitinib on the upstream pathway for the induction of NOD2 expression and proinflammatory cytokine production was assessed using monocytic cell lines differentiated from Blau syndrome patient-derived induced pluripotent stem cells.ResultsTofacitinib did not suppress the increased spontaneous transcriptional activity of NF-κB by mutant NOD2. In addition, mutant NOD2 was not involved in the transcription of ISRE and GAS, which are activated by type 1 and type 2 interferons (IFN), respectively. On the other hand, IFNγ induced the expression of NOD2, which led to the production of inflammatory cytokines by an autoinflammatory mechanism only in cells with mutant NOD2. DiscussionTofacitinib suppressed the induction of NOD2 by IFNγ, thereby inhibiting the production of pro-inflammatory cytokines. Thus, tofacitinib showed anti-inflammatory effects through suppression of NOD2 expression. The JAK inhibitor tofacitinib is a potential therapeutic agent for Blau syndrome because it suppresses the autoinflammation seen in Blau syndrome by inhibiting the expression of NOD2.
Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing
Authors: Zhang Chuan-bao , Wang Zhi-liang , Liu Han-jie , Wang Zheng , Jia Wang 
Published: June 2023

ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported. However, the implications of these tumor-associated reactive astrocytes (TARAs) in glioma are not known.MethodsWe comprehensively assessed TARAs in gliomas, both in single cells and at the bulk tumor level, by analyzing five independent datasets. First, we analyzed two single-cell RNA sequencing datasets of 35,563 cells from 23 patients to estimate the infiltration level of TARAs in gliomas. Second, we collected clinical information and genomic and transcriptomic data of 1,379 diffuse astrocytoma and glioblastoma samples from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas datasets to evaluate the genomic, transcriptomic and clinical characteristics of TARA infiltration. Third, we downloaded expression profiles of recurrent glioblastoma samples from patients receiving PD-1 inhibitors to analyze the predictive value of TARAs for immune checkpoint inhibition.ResultsSingle-cell RNA sequencing data showed TARAs were abundant in the glioma micro-environment (15.7% in the CGGA dataset and 9.1% in the Gene Expression Omnibus GSE141383 dataset, respectively). Bulk tumor sequencing data showed that the extent of TARA infiltration was highly associated with major clinical and molecular features of astrocytic gliomas. Patients with more TARA infiltration were more likely to have MUC16, FLG, and PICK3A mutations, chromosome 9p21.3, 10q23.3, and 13q14.2 deletions and 7p11.2 amplification. Gene Ontology analysis revealed that the high level of astrocyte infiltration was characterized by immune and oncogenic pathways, such as the inflammatory response, positive regulation of the JAK–STAT cascade, positive regulation of NIK/NF-kappa B signaling and the tumor necrosis factor biosynthetic process. Patients with greater TARA infiltration showed inferior prognosis. Meanwhile, the extent of reactive astrocyte infiltration exhibited a predictive value for recurrent glioblastoma patients undergoing anti-PD-1 immune therapy.ConclusionTARA infiltration might promote glioma tumor progression and can be used as a diagnostic, predictive and prognostic marker in gliomas. Prevention of TARA infiltration might be a new therapeutic strategy for glioma.
Tocilizumab (monoclonal anti-IL-6R antibody) reverses anlotinib resistance in osteosarcoma
Authors: Xu Jiuhui , Chen Chenglong , Sun Kunkun , Shi Qianyu , Wang Boyang , Huang Yi , Ren Tingting , Tang Xiaodong 
Published: June 2023

PurposeAnlotinib, a tyrosine kinase inhibitor (TKI) has been in clinical application to inhibit malignant cell growth and lung metastasis in osteosarcoma (OS). However, a variety of drug resistance phenomena have been observed in the treatment. We aim to explore the new target to reverse anlotinib resistance in OS.Materials and MethodsIn this study, we established four OS anlotinib-resistant cell lines, and RNA-sequence was performed to evaluate differentially expressed genes. We verified the results of RNA-sequence by PCR, western blot and ELISA assay. We further explored the effects of tocilizumab (anti- IL-6 receptor), either alone or in combined with anlotinib, on the inhibition of anlotinib-resistant OS cells malignant viability by CCK8, EDU, colony formation, apoptosis, transwell, wound healing, Cytoskeletal stain assays, and xenograft nude mouse model. The expression of IL-6 in 104 osteosarcoma samples was tested by IHC.ResultsWe found IL-6 and its downstream pathway STAT3 were activated in anlotinib-resistant osteosarcoma. Tocilizumab impaired the tumor progression of anlotinib-resistant OS cells, and combined treatment with anlotinib augmented these effects by inhibiting STAT3 expressions. IL-6 was highly expressed in patients with OS and correlated with poor prognosis.ConclusionTocilizumab could reverse anlotinib resistance in OS by IL-6/STAT3 pathway and the combination treatment with anlotinib rationalized further studies and clinical treatment of OS.