bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are CSR and advertising complements or substitutes in spurring firm visibility? Moderating effect of board diversity, CSR committees, and financial slack
Authors: Karmani Majdi , Kuzey Cemil , Uyar Ali , Karaman Abdullah S. 
Published: August 2023

AbstractThis paper examines corporate social responsibility (CSR) and advertising as two firm visibility channels and tests their complementarity/substitution. The study extends the investigation with moderating variables, including board gender diversity, CSR committees, and financial slack. Using a sample that includes 53,835 firm‐year observations worldwide associated with 10 business sectors from 2007 to 2019, we find that CSR performance is negatively associated with advertising; this holds for the aggregate CSR score as well as for environmental and social pillars but not for the governance pillar. This implies that two visibility channels—namely CSR and advertising—are substitutes except for the governance dimension. Furthermore, female directors do not advocate for the two visibility channels but instead are proponents of one, in line with the agency cost approach. However, CSR committees fully promote two communication channels supported by the composite and three individual pillars of CSR. Finally, financial slack matters in utilizing two publicity channels concurrently. The findings show that several contingencies must be taken into account to improve companies' visibility while avoiding exacerbating agency costs for better business management.
High speed calculation method using convolution for calculating normal and disaster costs of buildings with energy generation and storage facilities
Authors: Kinoshita Sota , Yamaguchi Nobuyuki , Kimura Yuta , Sato Fuyuki , Otani Shinichiro 
Published: August 2023

AbstractIn recent years, resilience‐enhanced building buildings have been attracting increasing attention, in which photovoltaic (PV) power generation and storage batteries are installed in office buildings to continue operations even during a grid outage. PV power generation and storage batteries can be introduced to office buildings to continue commercial operations in the case of grid outages. When introducing PV power generation and storage batteries into a building, the total cost, which is the sum of the equipment installation cost and the damage cost in the event of a disaster, is crucial. When installing PV power generation and storage batteries in a building and calculating the total cost of using these facilities in the event of a disaster, it is necessary to consider the uncertainty of power demand and the amount of power generated by PV power generation. Monte Carlo Simulation is a method to consider uncertainty. However, it has a problem that the combination of conditions becomes enormous, and the calculation load is high when the total cost is calculated. Therefore, in this study, we propose convolution as a method to reduce the computational load generated when calculating the probability distribution of the total cost generated by strengthening the resilience of the building.
Influence of background medical therapy on efficacy and safety of dapagliflozin in patients with heart failure with improved ejection fraction in the DELIVER trial
Authors: Pabon Maria , Claggett Brian L. , Wang Xiaowen , Miao Zi Michael , Chatur Safia , Bhatt Ankeet S. , Vaduganathan Muthiah , Fang James C. , Desai Akshay S , Jhund Pardeep , Martinez Felipe , de Boer Rudolf A. , Kosiborod Mikhail N. , Lam Carolyn S.P. , Shah Sanjiv J. , Hernandez Adrian F. , McMurray John J.V. , Solomon Scott D. , Vardeny Orly 
Published: August 2023

AbstractAimsThe Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure (DELIVER) trial demonstrated the sodium–glucose cotransporter 2 inhibitor dapagliflozin to be beneficial in patients with symptomatic heart failure (HF) with improved ejection fraction (HFimpEF; those with prior left ventricular ejection fraction ≤40% that had improved to >40% by enrolment). Whether this benefit differs by background medical therapy is unclear. The current study aims to determine the efficacy and safety of dapagliflozin among patients with HFimpEF by background medical therapy.Methods and resultsTreatment effects on the primary endpoint (worsening HF or cardiovascular death) were assessed by number of background HF medical therapies (angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor–neprilysin inhibitor, evidence‐based beta‐blocker, and mineralocorticoid receptor antagonist). Among the 6263 patients randomized in DELIVER, 1151 (18%) had HFimpEF. Of those, 21% of patients were on 0–1 therapies, 44% were on two therapies, and 35% were on three therapies. During 2.3 years of median follow‐up, the incidence rate of the primary outcome was 9.7, 8.8, and 8.4 per 100 person‐years for patients on 0–1, 2 and 3 HF medications at baseline, respectively. Treatment effects with dapagliflozin on the primary outcome may be greater in patients with HFimpEF on 0–1 therapies at baseline (pinteraction = 0.09), driven mostly by a significant interaction for HF hospitalization (pinteraction = 0.023) with no evidence of effect modification for cardiovascular death (pinteraction = 0.65). Treatment effects of dapagliflozin on the primary outcome were, however, consistent when assessed across the modified Heart Failure Collaboratory Medical Therapy Score integrating both therapeutic use and dosing (pinteraction = 0.39). The use of dapagliflozin was not associated with changes in use or doses of background HF therapies, and among patients on three HF medications at baseline, the addition of dapagliflozin did not lead to higher adverse events.ConclusionsIn patients with HFimpEF, the safety and efficacy of dapagliflozin were largely similar by background use and dosing of HF medical therapies. The benefit of dapagliflozin in reducing HF events tended to be greater in those patients on 0‐1 medications at baseline. Among patients already on three HF medical therapies, the addition of dapagliflozin was safe without requiring de‐escalation of other therapies.
Stressful life events and low back pain in older men: A cross‐sectional and prospective analysis using data from the MrOS study
Authors: McNaughton David T. , Roseen Eric J. , Downie Aron , Jenkins Hazel , Øverås Cecilie K. , Young Justin J. , Fink Howard A. , Stone Katie L. , Cawthon Peggy , Hartvigsen Jan 
Published: August 2023

AbstractBackgroundStressful life events, such as loss of a partner, loss of a pet or financial problems, are more common with increasing age and may impact the experience of pain. The aim of the current study is to determine the cross‐sectional and prospective association between stressful life events and low back pain reporting in the Osteoporotic Fracture in Men Study, a cohort of older men aged ≥65 years.MethodsAt a study visit (March 2005–May 2006), 5149 men reported whether they had experienced a stressful life event or low back pain in the prior 12 months. Following that visit, data on low back pain patients were gathered through triannual questionnaires every 4 months for 1 year. Multivariable logistic regression analyses estimated the association of stressful life events with recent past low back pain or future low back pain.ResultsN = 2930, (57%) men reported at least one stressful life event. The presence of a stressful life event was associated with greater odds of any low back pain (OR = 1.42 [1.26–1.59]) and activity‐limiting low back pain (OR = 1.74 [1.50–2.01]) in the same period and of any low back pain (OR = 1.56 [1.39–1.74]) and frequent low back pain (OR = 1.80 [1.55–2.08]) in the following year.ConclusionIn this cohort of men, the presence of stressful life events increased the likelihood of reporting past and future low back pain.SignificanceStressful life events such as accident or illness to a partner are common in later life and may impact the experience of pain. We present cross‐sectional and prospective data highlighting a consistent association between stressful life events and low back pain in older men. Further, there is evidence to suggest that this relationship is upregulated by an individual's living situation. This information may be used to strengthen a biopsychosocial perspective of an individual's pain experience.
A novel GABRG2 variant in Sunflower syndrome: A case report and video EEG monitoring
Authors: Sourbron Jo , Proost Renee , Jansen Katrien , Riva Antonella , Eschermann Kirsten , Barnett James Richard , Lagae Lieven 
Published: August 2023

AbstractObjectiveSunflower syndrome is a unique photosensitive epilepsy, characterized by heliotropism and stereotyped seizures associated with handwaving. These handwaving events (HWE) are thought to be an ictal phenomenon, although current data are contrasting. Photosensitive epilepsy occurs in 2%–5% of the epilepsy forms and several pathogenic gene variants have been associated with photosensitive epilepsy. However, the genetic etiology of Sunflower syndrome remains unknown. Antiseizure medications (ASM) efficacious in treating photosensitive epilepsy are valproic acid (VPA) and levetiracetam (LEV) although some forms, such as Sunflower syndrome, can be drug‐resistant.Methods and ResultsHere, we report an 8‐year‐old boy with an early onset of episodes of HWE that was initially categorized as behavioral problems for which risperidone was started. However, the medical history was suggestive of Sunflower syndrome, and subsequent video EEG showed focal mostly temporal and frontotemporal (right and left) epileptiform activity and confirmed the epileptic nature of the HWE. Thus, VPA was started and initially led to seizure frequency reduction. Molecular analyses showed a pathogenic variant in GABRG2 (c.1287G>A p.(Trp429Ter)), which has been associated with photosensitive and generalized epilepsy.SignificanceOverall, clinicians worldwide should be cautious by interpreting HWE and/or other tic‐like movements, since an epileptic origin cannot be ruled out. A prompt and correct diagnosis can be made by performing a video EEG early on in the diagnostic process when epileptic seizures are part of the differential diagnosis. Even though the genetic etiology of Sunflower syndrome remains poorly understood, this constellation supports further genetic testing since the detection of a pathogenic variant can help in making correct decisions regarding ASM management.
Comparison of potent odorants in high‐salt liquid‐state fermentation soy sauce before and after sterilization
Authors: Liu Yuping , Wang Rui , Guan Wei , Bai Jiawei , Zhou Shangting , Chen Liang 
Published: August 2023

AbstractTo compare the changes of potent odorants (PO) in high‐salt liquid‐state fermentation soy sauce (HLFSS) after sterilization under 120°C for 15 s, the volatiles in HLFSS were isolated by solvent extraction combined with solvent‐assisted flavour evaporation and were analysed by gas chromatography‐mass spectrometry‐olfactometry. A total of 40 odour‐active compounds were identified, and their flavour dilution (FD) factors ranging from 1 to 4096 were determined by comparative aroma extract dilution analysis. Twenty‐four compounds with FD factors ≥8 were quantitated by establishing standard curves, and the results showed that total concentrations of alcohols and phenols were almost unchanged, those of esters, acids and pyrazines decreased and those of aldehydes and ketones increased. Based on quantitative results and thresholds in water, odour activity values (OAVs) were calculated. Eighteen compounds with OAVs ≥1 were determined as PO in HLFSS. The number of POs did not change after sterilization, and OAVs of 10 POs remained unchanged or varied very little. The significant changes in the concentrations of methional, 5‐ethyl‐4‐hydroxy‐2‐methyl‐3(2H)‐furanone, nonanal, ethyl 2‐methylbutanoate, methionol, benzeneacetaldehyde, 4‐hydroxy‐2,5‐dimethyl‐3(2H)‐furanone and 2‐ethyl‐3,5‐dimethylpyrazine after sterilization caused the obvious variations of OAVs, which made cooked potato, caramel‐like, fatty and floral notes in HLFSS change in different degrees. The results obtained have some reference value to produce SS.
Forecasting base metal prices with exchange rate expectations
Authors: Brown Pablo Pincheira , Hardy Nicolás 
Published: August 2023

AbstractIn this paper, we show that survey‐based expectations of the Chilean exchange rate have the ability to predict the returns of the six primary non‐ferrous metals: aluminum, copper, lead, nickel, tin, and zinc. Predictability is also found for returns of the London Metal Exchange Index. Previous studies have shown that the Chilean exchange rate has the ability to predict copper returns, a world commodity index and base metal prices. Nevertheless, our results indicate that expectations about the Chilean peso have stronger predictive ability relative to the first lag of the Chilean currency. This is shown both in‐sample and out‐of‐sample. By focusing on expectations of a commodity currency, and not on the currency itself, our paper provides indirect but new and strong evidence of the ability that commodity currencies have to forecast commodity prices.
Suckling or non‐suckling? Sensory characterization of commercialized lamb meat according to feeding
Authors: Etaio Iñaki , Bravo‐Lamas Leire , Pérez‐Elortondo Francisco José , Barron Luis Javier R. , Aldai Noelia 
Published: August 2023

AbstractConsumption of meat from suckling lambs is typical in some regions. However, sensory differences between meat from suckling and non‐suckling lambs are barely described in previous studies. The objectives of the present study were (a) to develop a method to describe the sensory characteristics of lamb meat, including the development of sensory references for odor, flavor, and texture attributes; and (b) to study the sensory differences between lamb meat commercialized as “suckling lamb” and that commercialized without this designation. Twenty‐three sensory attributes were selected, and their corresponding sensory references were developed. A detailed procedure to evaluate the samples was also set up. This methodology was used to characterize samples (n = 48) from a survey of lamb meat from different types of stores (n = 23). Half of the samples were commercialized as sucking lamb and the other half (older lambs) without this indication. Samples were bought in two seasons (May and December) to consider possible seasonal effects. Samples were evaluated in triplicate by 12 trained assessors. Data were analyzed by ANOVA (p ≤ .05). Apart from how long juiciness was maintained (“maintained juiciness”), all the selected attributes were appropriate to discriminate between samples. Lamb meat sold as “suckling” did not differ from the other lamb samples in odor and flavor, but there were clear differences in texture attributes: meat sold as suckling lamb was tenderer and juicier, with higher crumbliness, and with lower fibrousness, chewiness, and residue than non‐suckling lamb meat. Several sensory characteristics, mainly related to odor and flavor, varied according to the season.
Occurrence and risk characterization of aflatoxin M1 in milk samples from southeastern Iran using the margin of exposure approach
Authors: Ghaffarian‐Bahraman Ali , Mohammadi Salman , Dini Ali 
Published: August 2023

AbstractThis study aimed to investigate Aflatoxin‐M1 (AFM1) contamination in pasteurized and raw milk samples consumed in Kerman and Rafsanjan in southeastern Iran. In this cross‐sectional study, a total of 100 samples of raw (n = 67) and pasteurized (n = 33) milk were randomly collected from retail stores, supermarkets, and milk transport tankers in the winter of 2020 and the summer of 2021. The level of AFM1 contamination in the collected samples was evaluated by high‐performance liquid chromatography with fluorescence detection (HPLC‐FD). AFM1 was detected in 95% of samples and its median concentration was 17.38 ng/L. The median concentration of AFM1 in the pasteurized milk samples (24.89 ng/L) was significantly higher than in the raw milk samples (13.54 ng/L). The AFM1 contamination level in 20% (raw = 13% and pasteurized = 7%) of the samples was higher than the maximum permitted level (MPL) recommended by the European Union (i.e., 50 ng/L), whilst 4% (raw = 3% and pasteurized = 1%) of the samples was higher than the Iranian maximum standard limit (i.e., 100 ng/L). The hazard index (HI) was higher than 1 in 16%, 18%, and 35% of total milk samples for men, women, and children, respectively. The AFM1 contamination level in the milk samples collected in southeastern Iran was worrying. The margin of exposure (MoE) values were lower than 10,000 for children. Because aflatoxins are among the most potent carcinogens known, prevention of milk contamination in all stages from the farm to the table can considerably reduce the community's exposure to AFM1 and its consequent health risks.
The synergistic effect of titanium dioxide nanoparticles and yeast isolated from fermented foods in reduction of aflatoxin B1
Authors: Nasiri Poroj Shohreh , Larypoor Mohaddeseh , Fazeli Mohammad Reza , Shariatmadari Farid 
Published: August 2023

AbstractThe presence of aflatoxins in food products can lead to health risks in human societies. Therefore, in the present study, the effect of yeast strains isolated from fermented products and titanium dioxide nanoparticles (TiO2‐NPs) was studied on aflatoxin reduction. Yeast strains were isolated from fermented products such as sweet fruits and dairy products and identified using biochemical, ascospore (testing by culture medium optimization V8 which is called V8NLF), and molecular methods. The probiotic activity of four selected yeasts was evaluated. Then, the effect of selected yeast isolates and TiO2‐NPs on reducing aflatoxin B1 (AFB1) in the medium was studied by measuring AFB1 using ELISA and HPLC. The results of biochemical and molecular identification experiments indicate that the selected strain (Y1) is Saccharomyces cerevisiae. The selected strains showed good tolerance to different concentrations of bile salt, pH, and NaCl, indicating appropriate probiotic activity. It also showed antimicrobial activity against Escherichia coli, Shigella dysenteriae, and Salmonella typhimurium. Selected strain and TiO2‐NPs showed AFB1 reducing activity in the medium and when combined, showed synergistic effects in reducing AFB1. TiO2‐NPs in combination with selected yeast strains have a high ability to remove AFB1 from the medium and, therefore, can be used for future studies.
Toward Photoactive Wallpapers Based on ZnO‐Cellulose Nanocomposites
Authors: Alvi Naveed Ul Hassan , Sepat Neha , Sardar Samim , Berggren Magnus , Engquist Isak , Crispin Xavier 
Published: August 2023

AbstractThe quest for eco‐friendly materials with anticipated positive impact for sustainability is crucial to achieve the UN sustainable development goals. Classical strategies of composite materials can be applied on novel nanomaterials and green materials. Besides the actual technology and applications also processing and manufacturing methods should be further advanced to make entire technology concepts sustainable. Here, they show an efficient way to combine two low‐cost materials, cellulose and zinc oxide (ZnO), to achieve novel functional and “green” materials via paper‐making processes. While cellulose is the most abundant and cost‐effective organic material extractable from nature. ZnO is cheap and known of its photocatalytic, antibacterial, and UV absorption properties. ZnO nanowires are grown directly onto cellulose fibers in water solutions and then dewatered in a process mimicking existing steps of large‐scale papermaking technology. The ZnO NW paper exhibits excellent photo‐conducting properties under simulated sunlight with good ON/OFF switching and long‐term stability (90 minutes). It also acts as an efficient photocatalyst for hydrogen peroxide (H2O2) generation (5.7 × 10−9 m s−1) with an envision the possibility of using it in buildings to enable large surfaces to spontaneously produce H2O2 at its outer surface. Such technology promise for fast degradation of microorganisms to suppress the spreading of diseases.
An 840 kb distant upstream enhancer is a crucial regulator of catecholamine‐dependent expression of the Bdnf gene in astrocytes
Authors: Avarlaid Annela , Esvald Eli‐Eelika , Koppel Indrek , Parkman Annabel , Zhuravskaya Anna , Makeyev Eugene V. , Tuvikene Jürgen , Timmusk Tõnis 
Published: August 2023

AbstractBrain‐derived neurotrophic factor (BDNF) plays a fundamental role in the developing and adult nervous system, contributing to neuronal survival, differentiation, and synaptic plasticity. Dysregulation of BDNF synthesis, secretion or signaling has been associated with many neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Although the transcriptional regulation of the Bdnf gene has been extensively studied in neurons, less is known about the regulation and function of BDNF in non‐neuronal cells. The most abundant type of non‐neuronal cells in the brain, astrocytes, express BDNF in response to catecholamines. However, genetic elements responsible for this regulation have not been identified. Here, we investigated four potential Bdnf enhancer regions and based on reporter gene assays, CRISPR/Cas9 engineering and CAPTURE‐3C‐sequencing we conclude that a region 840 kb upstream of the Bdnf gene regulates catecholamine‐dependent expression of Bdnf in rodent astrocytes. We also provide evidence that this regulation is mediated by CREB and AP1 family transcription factors. This is the first report of an enhancer coordinating the transcription of Bdnf gene in non‐neuronal cells.
Performance of the HPV E6/E7 mRNA Aptima HPV assay combined with partial genotyping compared with the HPV DNA Cobas 4800 HPV test for use in primary screening: Results from the CERVIVA HPV primary screening study in Ireland
Authors: White Christine , Reynolds Stephen , Murphy Katherine , Keegan Helen , Naik Padma , O'Brien Roisin , Pilkington Loretto , Sharkey Ochoa Imogen , Glesson Grainne , Russell Noirin , Nuttall David , Tewari Prerna , Wright Fiona , O'Toole Sharon , Sharp Linda , Flannelly Grainne , O'Leary John J. , Martin Cara M. ,   CERVIVA the Irish Cervical Screening Research Consortium
Published: August 2023

AbstractThere are currently several validated HPV tests. However, longitudinal data which spans appropriate age ranges, as well as evaluation of potential screening algorithms are necessary for screening programmes choice of test. The objective of our study was to evaluate the performance of HPV mRNA and HPV DNA testing, including partial genotyping, in routine cervical screening. As part of the CERVIVA HPV Primary Screening Study, ThinPrep samples from 10 150 women were tested for HPV mRNA using the Aptima HPV assay and HPV DNA using the Cobas 4800 HPV test. HPV mRNA‐positive women were further assessed with the Aptima genotyping assay for HPV 16/18/45. Baseline cytology and prospective follow‐up data were collected. The performance of the two tests was examined over 42 months (to date). HPV mRNA demonstrated equivalent sensitivity to HPV DNA testing for detection of CIN2+ (93.2% [92.4‐93.9] vs 92.8% [92.0‐93.6], respectively) and CIN3+ (94.6% [93.8‐95.3] vs 94.6% [93.8‐95.3]). HPV mRNA testing had significantly higher specificity compared to HPV DNA for detection of CIN2+ (84.0% [83.5‐84.5] vs 80.8% [80.2‐81.4], respectively) and CIN3+ (88.44% [88.2‐88.6] vs 85.62 [85.4‐85.9]). The proportion of CIN2+ and CIN3+, over 3 years (42 months), in HPV‐negative women was comparable for both RNA (0.20% and 0.10%) and DNA (0.22% and 0.11%). Genotyping data was comparable across both assay platforms. In the context of HPV primary screening HPV mRNA testing has potential to reduce triage tests and follow‐up tests at 12 months compared to DNA testing, with no significant difference in detection of CIN2+ and CIN3+.