bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
Authors: Ma Xiaohui , Wu Xiaotong , Cao Shitai , Zhao Yinfeng , Lin Yong , Xu Yurui , Ning Xinghai , Kong Desheng 
Published: February 2023

AbstractSurgery represents a primary clinical treatment of solid tumors. The high risk of local relapse typically requires frequent hospital visits for postoperative adjuvant therapy. Here, device designs and system integration of a stretchable electronic device for wearable cancer treatment are presented. The soft electronic patch harnesses compliant materials to achieve conformal and stable attachment to the surgical wound. A composite nanotextile dressing is laminated to the electronic patch to allow the on‐demand release of anticancer drugs under electro‐thermal actuation. An additional flexible circuit and a compact battery complete an untethered wearable system to execute remote therapeutic commands from a smartphone. The successful implementation of combined chemothermotherapy to inhibit tumor recurrence demonstrates the promising potential of stretchable electronics for advanced wearable therapies without interfering with daily activities.
CRISPR‐Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids
Authors: Roh Yoon Ho , Lee Chang Yeol , Lee Sujin , Kim Hyunho , Ly Amy , Castro Cesar M. , Cheon Jinwoo , Lee Jae‐Hyun , Lee Hakho 
Published: February 2023

AbstractCRISPR/Cas systems offer a powerful sensing mechanism to transduce sequence‐specific information into amplified analytical signals. However, performing multiplexed CRISPR/Cas assays remains challenging and often requires complex approaches for multiplexed assays. Here, a hydrogel‐based CRISPR/Cas12 system termed CLAMP (Cas‐Loaded Annotated Micro‐Particles) is described. The approach compartmentalizes the CRISPR/Cas reaction in spatially‐encoded hydrogel microparticles (HMPs). Each HMP is identifiable by its face code and becomes fluorescent when target DNA is present. The assay is further streamlined by capturing HMPs inside a microfluidic device; the captured particles are then automatically recognized by a machine‐learning algorithm. The CLAMP assay is fast, highly sensitive (attomolar detection limits with preamplification), and capable of multiplexing in a single‐pot assay. As a proof‐of‐concept clinical application, CLAMP is applied to detect nucleic acid targets of human papillomavirus in cervical brushing samples.
Influence of potassium fertilization on alfalfa leaf and stem yield, forage quality, nutrient removal, and plant health
Authors: Heuschele Deborah Jo , Gamble Joshua , Vetsch Jeffrey A. , Shaeffer Craig C. , Coulter Jeffery A. , Kaiser Daniel E. , Lamb John A. , Lamb Jo Ann F. S. , Samac Deborah A. 
Published: February 2023

AbstractPotassium (K) is an essential nutrient for plant growth. In K‐deficient soils, fertilization has been shown to increase herbage yield of alfalfa. The purpose of this study was to determine the effects of K fertilization on alfalfa leaf and stem yield, forage quality, nutrient removal, and plant health of a nonlodging experimental germplasm. Five alfalfa rotations had K fertilizer applied at three rates (0, 186, and 372 kg K ha−1) to soils already containing sufficient soil test K (223 mg kg−1). No overall yield differences were found related to K application rates, though K removal in total herbage increased by 30–58% with K fertilization, depending on alfalfa stand age. Leaf:stem ratios were not impacted by K fertilization. The concentrations of B, Ca, and Na decreased with K fertilization, while K concentrations increased, which may have resulted in B deficiencies. Leaf in vitro digestibility decreased significantly with the application of K. There was no benefit to crown rot disease resistance with increased K fertilization. This study supports that the addition of K to already sufficient soils does not lead to any additional economic benefits and may reduce productivity due to the reduction of B uptake and in vitro digestibility.
Impacts of winter wheat and cover crops on soil microbial diversity in a corn–soybean no‐till cropping system in Quebec (Canada)
Authors: Giusti Blandine , Hogue Richard , Jeanne Thomas , Lucotte Marc 
Published: February 2023

AbstractIntensive agriculture based on repeatedly plowing a monoculture is known to degrade the structural, chemical, and biological properties of soils. Conservation agriculture is gaining popularity worldwide with practices including reduced tillage, increased plant diversity, and implementation cover crops. The aim of this study was to assess the impact of crop rotation and cover crops on soil microbial communities. The hypothesis was that enhanced plant diversity would boost the diversity of the soil microbiome. Two rotation were tested by adding a cereal (corn [Zea mays L.]–soybean [Glycine max (L.) Merr.] and corn–soybean–wheat [Triticum aestivum L.]), as well as the implementation of cover crops. The enhanced plant diversity had no impact on total molecular biomass. The bacteria/fungi ratio varied across the plots but was not clearly linked to the enhanced plant diversity. Bacterial richness was not influenced by the treatments, whereas eukaryotic richness decreased in the presence of cover crops in one of the sites. Microbial composition was the most sensitive indicator to enhanced plant diversity. Differential relative abundance (log2 fold changes) identified proteobacterial amplicon sequence variants (ASVs) specifically related to each crop rotation system and to the presence of cover crops. There was more ASV of Actinobacteria associated with the three‐crop rotation system and less ASV of Acidobacteria associated with the cover crops system compared to the two‐ and three‐crop rotation systems, respectively. As for eukaryotes, the number of ASVs belonging to Ascomycota and Cercozoa phyla and associated with the three‐crop rotation system is less important than for the two‐crop rotation system. This study shows that conservation agricultural practices can influence soil microbial communities. The variations in some ASVs could have functional implications on organic matter decomposition or plant growth and in terms of soil ecosystem services and field crop sustainability.
Optimizing sowing date and plant density improve peanut yield by mitigating heat and chilling stress
Authors: Liu Chunyan , Xu Yi , Zhao Jie , Nie Jiangwen , Jiang Yao , Shang Mengjie , Zang Huadong , Yang Yadong , Brown Robert W. , Zeng Zhaohai 
Published: February 2023

AbstractPeanut (Arachis hypogea L.) yield is dramatically declined by extreme weather stresses under climate change. Adjusting the sowing date and plant density are effective strategies to mitigate these stresses and improve peanut yield. However, a mechanistic understanding of the influence of environmental drivers and an optimized strategy have yet to be developed. Here, a 3‐year field experiment was conducted to evaluate the sowing date (April 25, early sowing; May 5, middle sowing; May 15, late sowing) and plant density (24, 30, and 36 plants m−2 as low, medium, and high) of peanut in the North China Plain. We found that higher pod yield was observed in the middle sowing (∼4492.4 kg ha−1) compared with the early and late sowing (∼3317.2 and 4088.1 kg ha−1, respectively). Meanwhile, the pod yield in high density (∼4162.5 kg ha−1) was 10.6% and 4.7% higher than low and medium density, respectively, mainly due to higher leaf area index. The relative peanut pod yield was positively correlated with the average minimum temperature 5 days before and after the flowering pegging stage, whilst it was negatively correlated with average maximum temperature 5 days before and after pod filling stage. Therefore, optimizing temperature conditions to improve the peanut yield can be achieved by adjusting the sowing date. In conclusion, sowing date and plant density manipulation constitute a useful method to mitigate heat and chilling stress and improve peanut yield.
Severe left kidney laceration after minor fall in a patient with lumbar spine scoliosis
Authors: Sugimoto Takashi , Ono Yuko , Ueshima Eisuke , Matsushiro Keigo , Yamada Isamu , Kotani Joji 
Published: February 2023

BackgroundThe kidneys are one of the organs most commonly affected by blunt trauma; however, the anatomical variations that predispose kidney injury are poorly understood.Case PresentationAn 80‐year‐old Japanese woman with lumber scoliosis was brought to our hospital because of severe flank pain after a minor fall at home. Contrast‐enhanced computed tomography showed a severe left kidney laceration at the level of an acute angle in the vertebral column caused by scoliosis. Extravasation of contrast medium from the left renal artery branches was also noted. Selective arterial embolization achieved hemostasis. The patient was transferred to a rehabilitation facility without sequelae.ConclusionPatients with scoliosis could be at higher risk of severe kidney laceration because of intrusion of the vertebral column into the retroperitoneal space. Therefore, even after low‐impact trauma, active exploration for kidney injury could be warranted in patients with spinal curvature disorders.
Stacking Cyclophanes into Chiral Microvessels
Authors: Hassan Zahid , Bräse Stefan 
Published: February 2023

AbstractEngineering novel micro‐/nanoscale systems and devices based on supramolecular assembly has tremendous potential from diverse applications perspective. However, controlling the size, shape, spatial arrangements, and hierarchical transcription by a dimensional organizing principle (1D–3D arrangement) without the help of templates remains a challenging task. In this vein, a recent study by Oki and colleagues reporting the stacking of chiral cyclophanes via intermolecular non‐covalent interactions for crafting synchronous microcrystalline 3D chiral vessels with controlled conformational arrangements represents a truly remarkable illustration of molecular engineering. The microvessels bear stereocontrolled skeletal morphology, recognize stereoisomers and serve as containers to accommodate microcrystals, polymer particles, and fluorescent dyes. The full application scope of this fascinating research is far beyond non‐covalent interactions, supramolecular self‐assembly, and crystal engineering.
Exceptionally Stable Dimers and Trimers of Au25 Clusters Linked with a Bidentate Dithiol: Synthesis, Structure and Chirality Study
Authors: Swierczewski Michal , Cousin Fabrice , Banach Ewa , Rosspeintner Arnulf , Lawson Daku Latevi Max , Ziarati Abolfazl , Kazan Rania , Jeschke Gunnar , Azoulay Raymond , Lee Lay‐Theng , Bürgi Thomas 
Published: February 2023

AbstractA bidentate chiral dithiol (diBINAS) is utilised to bridge Au25 nanoclusters to form oligomers. Separation by size allows the isolation of fractions that are stable thanks to the bidentate nature of the linker. The structure of the products is elucidated by small‐angle X‐ray scattering and calculated using density functional theory. Additional structural details are studied by diffusion‐ordered nuclear magnetic resonance spectroscopy, transmission electron microscopy and matrix‐assisted laser desorption/ionization time of flight mass spectrometry. Significant changes in the optical properties are analysed by UV/Vis and fluorescence spectroscopies, with the latter demonstrating a strong emission enhancement. Furthermore, the emergent chiral characteristics are studied by circular dichroism. Due to the geometry constraints of the nanocluster assemblies, diBINAS can be regarded as a templating molecule, taking a step towards the directed self‐assembly of metal clusters.
Rhodium‐Catalyzed Asymmetric Arylation of Cyclobutenone Ketals
Authors: Egea‐Arrebola David , Goetzke F. Wieland , Fletcher Stephen P. 
Published: February 2023

AbstractComplex cyclobutanes are important motifs in both bioactive molecules and natural products, yet their enantioselective preparation has not been widely explored. In this work, we describe rhodium‐catalyzed enantioselective additions of aryl and vinyl boronic acids to cyclobutenone ketals. This transformation involves enantioselective carbometalation to give cyclobutyl‐rhodium intermediates, followed by β‐oxygen elimination to afford enantioenriched enol ethers. Overall, this addition serves as a surrogate for Rh‐catalyzed 1,4‐additions to cyclobutenone.
Evolution of Stabilized 1T‐MoS2 by Atomic‐Interface Engineering of 2H‐MoS2/Fe−Nx towards Enhanced Sodium Ion Storage
Authors: Xia Huicong , Zan Lingxing , Yuan Pengfei , Qu Gan , Dong Hongliang , Wei Yifan , Yu Yue , Wei Zeyu , Yan Wenfu , Hu Jin‐Song , Deng Dehui , Zhang Jia‐Nan 
Published: February 2023

AbstractMetallic conductive 1T phase molybdenum sulfide (MoS2) has been identified as promising anode for sodium ion (Na+) batteries, but its metastable feature makes it difficult to obtain and its restacking during the charge/discharge processing result in part capacity reversibility. Herein, a synergetic effect of atomic‐interface engineering is employed for constructing 2H‐MoS2 layers assembled on single atomically dispersed Fe−N−C (SA Fe−N−C) anode material that boosts its reversible capacity. The work‐function‐driven‐electron transfer occurs from SA Fe−N−C to 2H‐MoS2 via the Fe−S bonds, which enhances the adsorption of Na+ by 2H‐MoS2, and lays the foundation for the sodiation process. A phase transfer from 2H to 1T/2H MoS2 with the ferromagnetic spin‐polarization of SA Fe−N−C occurs during the sodiation/desodiation process, which significantly enhances the Na+ storage kinetics, and thus the 1T/2H MoS2/SA Fe−N−C display a high electronic conductivity and a fast Na+ diffusion rate.
Enabled Efficient Ammonia Synthesis and Energy Supply in a Zinc–Nitrate Battery System by Separating Nitrate Reduction Process into Two Stages
Authors: Jiang Haifeng , Chen Gao‐Feng , Savateev Oleksandr , Xue Jian , Ding Liang‐Xin , Liang Zhenxing , Antonietti Markus , Wang Haihui 
Published: February 2023

AbstractThe aqueous electrocatalytic reduction of NO3−into NH3(NitrRR) presents a sustainable route applicable to NH3production and potentially energy storage. However, the NitrRR involves a directly eight‐electron transfer process generally required a large overpotential (<−0.2 V versus reversible hydrogen electrode (vs. RHE)) to reach optimal efficiency. Here, inspired by biological nitrate respiration, the NitrRR was separated into two stages along a [2+6]‐electron pathway to alleviate the kinetic barrier. The system employed a Cu nanowire catalyst produces NO2−and NH3with current efficiencies of 91.5 % and 100 %, respectively at lower overpotentials (>+0.1vs. RHE). The high efficiency for such a reduction process was further explored in a zinc‐nitrate battery. This battery could be specified by a high output voltage of 0.70 V, an average energy density of 566.7 Wh L−1at 10 mA cm−2and a power density of 14.1 mW cm−2, which is well beyond all previously reported similar concepts.
Micro‐nano structure constructed AA7055 superhydrophobic surface with long service life and high corrosion resistance
Authors: Guo Fuqiang , Duan Shuwei , Wu Dongting , Matsuda Kenji , Wang Tao , Zou Yong 
Published: February 2023

AbstractIn this article, a high corrosion‐resistant and environmentally stable superhydrophobic layer was fabricated on the surface of 7055 aluminum alloy using surface silanization and constructing a secondary micro‐nano structure with polytetrafluoroethylene and SiO2 nanoparticles on the polydimethylsiloxane surface. The sprayed nanoparticles on the low‐energy surface layer can form a micro‐nano secondary structure, resulting in a superhydrophobic layer with excellent hydrophobic properties and long‐lasting stability. The superhydrophobic layer not only has good hydrophobicity, but also has good corrosion resistance, wear resistance and antiicing performance, the corresponding mechanisms were discussed.
Efficient Low Temperature Performance of All Solid‐State Zinc‐Air Batteries with MnCo2O4/Carbon Fiber Bifunctional Electrocatalyst and Poly(Acrylic Acid) (PAA) Gel Polymer Electrolyte
Authors: Abedi Zahra , Cui Jiayao , Chen Weixing , Ivey Douglas G. 
Published: February 2023

AbstractSpinel type MnCo2O4 coated on asphaltene based carbon fibers (MnCo2O4/CF) was used as the electrode material/electrocatalyst for air electrodes for zinc‐air batteries (ZABs). The batteries were assembled using an alkaline poly(acrylic acid) hydrogel electrolyte. The low temperature battery performance of the prepared ZAB cells was studied in terms of charge/discharge voltage and efficiency at different current densities, cycle life, power density, and cell voltage at temperatures between −45 °C and 21 °C. At all temperatures, the ZABs successfully completed 200 cycles of charge/discharge (100 h) at 2 mA cm−2 which is double the current density reported in the recent literature. The maximum power densities at 0 and −45 °C were 75 and 12 mW cm−2, respectively. The good performance is attributed to the porous design of the air electrode and the use of an efficient electrocatalyst and an optimized gel polymer electrolyte.
Creating shared value through open innovation approaches: Opportunities and challenges for corporate sustainability
Authors: Camilleri Mark Anthony , Troise Ciro , Strazzullo Serena , Bresciani Stefano 
Published: February 2023

AbstractTo date, few researchers have linked open innovation approaches with triple bottom line corporate sustainability objectives in terms of economic, social, and environmental performance. A systematic review suggests that the businesses' collaborative relationships with external consultants or organizations can increase their competitive advantage, as external stakeholders could assist them in the development of sustainable innovations, diversification into different markets, and in the generation of new revenue streams. At the same time, they can support them in addressing numerous deficits in society. On the other hand, this contribution implies that an organizational culture that promotes open innovation approaches could expose practitioners to risks and uncertainties, like revealing sensitive information to outsiders, among others. In reality, it may prove difficult for the businesses to trust new partners, as they are not subject to their organizations' codes of conduct, rules, and regulations.
Matching‐adjusted indirect comparison of isatuximab plus carfilzomib and dexamethasone with daratumumab plus lenalidomide and dexamethasone in relapsed multiple myeloma
Authors: Richter Joshua , Lin Peggy L. , Garcia‐Horton Viviana , Guyot Patricia , Singh Erin , Zhou Zheng‐Yi , Sievert Mark , Taiji Riley 
Published: February 2023

AbstractBackgoundLenalidomide‐based regimens are commonly used for early relapse in patients with relapsed and/or refractory multiple myeloma (RRMM) receiving at least one prior line of therapy. In the absence of head‐to‐head comparison, matching‐adjusted indirect comparison (MAIC) was conducted to demonstrate efficacy and safety of isatuximab+carfilzomib+dexamethasone (Isa‐Kd) versus daratumumab + lenalidomide + dexamethasone (Dara‐Rd) in RRMM.MethodsPatient‐level data from IKEMA trial (Isa‐Kd, n = 179) were matched to aggregate data from POLLUX (Dara‐Rd, n = 286). Hazard ratios (HR) and 95% confidence intervals (CI) for progression‐free survival (PFS) and overall survival (OS) were generated by weighted Cox proportional hazard models. Odds ratios (OR), 95% CI, and p‐value were calculated for ≥very good partial response (≥VGPR) and treatment‐emergent adverse events (TEAEs).ResultsAfter matching, no significant differences were observed between Isa‐Kd and Dara‐Rd in baseline characteristics except for patients with >3 prior lines (0.0% vs. 4.9%). Isa‐Kd showed significantly better PFS (HR [95% CI]: 0.46 [0.24–0.86]; p = 0.0155), statistically non‐significant improvement favoring Isa‐Kd in OS (0.47 [0.20–1.09]; 0.0798), and ≥VGPR (OR [95% CI]: 1.53 [0.89–2.64]; p = 0.1252) than Dara‐Rd. Odds of occurrence were significantly lower for some all‐grade and grade 3/4 TEAEs with Isa‐Kd than Dara‐Rd.ConclusionThese results support Isa‐Kd as an efficacious treatment for early relapse in non‐lenalidomide refractory patients.
Investigation of Botanical Origin, Phenolic Compounds, Carotenoids, and Antioxidant Properties of Monofloral and Multifloral Bee Bread
Authors: Çobanoğlu Duygu Nur , Şeker Mehmet Emin , Temizer İlginç Kizilpinar , Erdoğan Ayşegül 
Published: February 2023

AbstractBee bread is a unique natural product made by bees and good for human health. It has many bioactive molecules that can treat or prevent diseases. In this study, melissopalynological methods were used to examine five bee bread samples. Major plant sources found in bee bread were Lotus spp., Trifolium spp., and Xeranthemum spp., which are from the Fabaceae and Asteraceae families. Then, the amount of phenolic compounds and major carotenoids in bee bread (BB) samples were quantified. Gallic acid, caffeic acid, quercetin, and kaempferol were found in all BB samples, with β‐carotene being the most abundant carotenoid in all but BB1. In addition, the total phenolic/flavonoid content and antioxidant activities of all BB samples were determined. Total flavonoid, total phenolic, DPPH⋅, and ABTS⋅+ values were varied between 5.6–10.00 mg GAE/g DW, 1.2–4.3 mg QE/g DW, 1.2–5.5 mg TEAC/g DW, and 2.6–15.4 mg TEAC/g DW, respectively.
An Efficient and Eco‐Friendly Synthesis of Protoberberine and 13‐Me Protoberberine Alkaloids via Electrochemical Acceptorless Dehydrogenation
Authors: Li Weijian , Huang Shiqi , Jiang Meifen , Chen Yu , Yang Zhi , Tang Pei , Chen Fener 
Published: February 2023

AbstractA practicable and environmentally benign process for the synthesis of protoberberine (PB) and 13‐methylprotoberberine (13‐MePB) alkaloids is reported. In contrast to previous dehydrogenation of saturated C ring utilizing a stoichiometric oxidant, the electrocatalytic approach through I2‐mediated electrochemical acceptorless dehydrogenation (ECAD) can eco‐efficiently construct aromatized C ring of PBs and 13‐MePBs in last‐stage. This new method to the aromatization of tetracyclic framework has been applied to divergent syntheses of ten PBs and eight 13‐MePBs in high yields. Importantly, this I2‐ECAD protocol can be conducted on a gram scale and applied in a continuous‐flow microreactor successfully. Given such practicability and efficiency, the developed synthetic strategy meets many salient features of green chemistry, and would be greatly beneficial to the synthesis of important isoquinoline fine chemicals and relevant natural products.