bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social acceptance of stingless bee honey cultivation for sustainable bioproduction system
Authors: Noorahya F , Withaningsih S , Parikesit  
Published: July 2023

Abstract
Stingless bee honey cultivation is one of the bioproduction systems that is predicted to have a high sustainability value. There are 3 indicators in assessing the sustainability of a system taken from the 3 main pillars of sustainability, namely economic, environmental, and social indicators. This study discusses the social sustainability of stingless bee honey cultivation through one of its elements, namely social acceptance. The research was conducted through a case study in one of the stingless bee honey cultivation sites in Sumedang Regency. The data collected is data on community characteristics and data on social acceptance regarding stingless bee honey cultivation. Community characteristics data shows that based on economic conditions, availability of human resources, and social status of the community, the practice of stingless bee cultivation has the potential to be carried out sustainably. Meanwhile, data on social acceptance related to cultivation show that public perceptions and attitudes generally support the sustainability of stingless bee cultivation, although on the other hand knowledge about the benefits of cultivation and community involvement behavior is still low. Therefore, to strengthen the social sustainability of this bioproduction system, it is necessary to introduce and provide assistance regarding cultivation practices to the community around the location.
Cabai Rawit (Capsicum frutescens L.) Value Chain: Agricultural Commodities Driving Inflation in Lombok Island
Authors: Pardian Pandi , Renaldi Eddy , Bustaman Arief , Santoso Teguh , Hardiawan Donny 
Published: July 2023

Abstract
Cabai rawit (capsicum frutescent) commodity is one of the agricultural commodities driving inflation on Lombok island. Lombok has the highest productivity cabai rawit in Indonesia. However, prices in the local market are lower than off Lombok island, so big traders prefer to sell cabai rawit outside the island than in the local market. In addition, almost in all the food dishes of the population, there are elements of cabe rawit, so the existence of cabai rawit has vital in the community. This research does conduct in East Lombok Regency, the largest cabai rawit (capsicum frutescent) production center in West Nusa Tenggara Province. This study uses a value chain analysis approach to understand various elements with the survey method. Value added in every actor analyzed by Hayami calculation that tailored. The results showed that farmers got the highest percentage of value additions, namely 60.6%, compared to collectors at 16.1%, big traders at 18.8%, and retailers at 4.5%. That is comparable to the farmer’s activity cultivating cabe rawit (capsicum frutescent) from the plant until harvest. Value-added in percent, the highest is farmer, but when viewed from the value added in income, big traders and collectors are the highest because income is affected by each actor’s number of sales.
Abundance of Microplastics and Hazard to the Environment in Estuary Water in Pemalang, Central Java, Indonesia
Authors: Rifandi Raditya Ahmad , Ratnasari Ardiana Vita 
Published: July 2023

Abstract
Microplastics are plastic particles measuring ±5 mm. The accumulation of microplastics will be a hazard and threat to the environment because of its persistent nature and difficult to degrade. Human activities and pollutant sources greatly affect the function of microplastics. This study aims to determine the types and types of microplastics in the waters at 5 locations of the Pemalang River estuary. Water sampling represents different activities, namely ponds, tourist attractions, mangrove areas, fish auction sites and river estuaries. The total result found was 19.10 x 102 particles/m3. The types of microplastics found were fibres, fragments and films. The highest abundance of microplastics was found on Widuri Beach with a total of 5.45 x 102 particles/m3. The most common type of microplastic found in Pemalang waters is film. This is presumably because Widuri beach is a beach that is dense with tourist visits. Meanwhile, the types of microplastics in mangrove areas, ship port, fish market and fishponds have a range of values that are not much different, namely 2.33 − 4.53 x 102 particles/m3. This is presumably because waste is more easily trapped in the mangrove roots and accumulates more.
Performance of slow sand filter reactor using geotextile for reducing total n and phosphate
Authors: Hamidah L N , Afkar K , Rahmayanti A , Fitrianah L 
Published: July 2023

AbstractWater pollution that occurs is mostly caused by industrial and domestic waste. One of the consequences of polluted water is the increase in total N and Phosphate which causes malfunction of animals and humans. This is a problem that needs attention to protect our life from the dangers of environmental pollution. Slow Sand Filter is an easy and inexpensive raw water treatment solution. The raw water used in this research is the Dungus Sidoarjo river. The acclimatization process was carried out for 14 days. Sand and gravel were used as filter media with a geotextile thickness of 0.2 and 4 cm. The sample is taken on the first, sixth, and twelfth days. The best reactor for reducing Total N and Phosphate is a reactor with a geotextile thickness of 0.2 cm (D2) on the first day of effluent taking, which is 84.5%, and a reactor with a thickness of 4 cm on the sixth day of effluent taking, which is 77%. The results of the One Way ANOVA test with a standard error (α) of 0.05 stated that there was no significant difference in the treatment of each reactor in reducing total N and Phosphate.
Synthesis and characterization of Ti0.9Ir0.1O2-activated carbon composite as a promising support for catalysts in electrochemical energy conversion
Authors: Pham Hien T Q , Pham Hau Quoc , Huynh Quyen , Nguyen Thao Ngoc , Huynh Ngoc-Han T , Nguyen Thanh-Quang , Huynh Tai Thien 
Published: July 2023

Abstract
Constructing robust support plays a key role in governing the overall catalytic efficiency of metal-based catalysts for electrochemical reactions in sustainable energy-related conversion systems. We herein use a solvothermal method to assemble Ti0.9Ir0.1O2-Activated C composites, exhibiting high surface area and electrical conductivity compared to the pure TiO2 material. The material characterisations and electrochemical behaviours of the as-obtained composites are systemically studied by XRD, FE-SEM-EDX mapping, FT-IR, XPS, BET, four-point technique, cyclic voltammetry, etc Notably, the effect of composition on the physical and electrochemical properties of the as-made composites is also explored, which indicated the significant improvement in surface area and electrical conductivity with increasing carbon content, while a reverse trend is observed in the electrochemical durability. Among all studied composites, the Ti0.9Ir0.1O2-Activated C (50:50 wt%) composite can be a suitable support for metal-based catalysts due to its balance in physical properties (electrical conductivity of 1.5 S cm−1 and surface area of 152.12 m2 g−1) and electrochemical corrosion resistance (high durability after 2000-cycling ADT). This study can open up an efficient strategy to enhance the catalytic performance of electrochemical processes.
Thermal pattern at kueishantao (KST) volcano of Taiwan from satellite-observed temperatures and its implication
Authors: Chan Hai-Po , Chan Yu-Chang 
Published: July 2023

Abstract
Kueishantao (KST) is an active volcanic island off the northeastern coast of Taiwan. Tectonically, it lies in the south of the Okinawa Trough and opposite to the Ilan plain, in which is the southwestern end of the trough. KST provides a convenient observation site for the subsurface geological and geothermal activity and mechanism at its proximity. Land surface temperature (LST) of volcanoes detected from satellite sensors reflects the thermal status of heat sources in the subsurface. LST thus is a key parameter to the understanding of the volcanic process and geothermal resources. This research utilizes the satellite-observed multi-temporal land surface temperature imagery in 1999–2022 on the Kueishantao volcano of Taiwan to explore its geothermal state. The U.S. NASA Earth-observing satellites onboard three thermal sensors (i.e., Landsat ETM+, Terra ASTER, and Aqua/Terra MODIS) derived time series of land surface temperature from 1999 are employed to define the past and current pattern of geothermal activity plus the future trend of the KST. The spatiotemporal LST distribution of KST volcano is explored and analyzed. The spatial LST distribution of the KST volcano indicates that LST anomaly areas are mainly located on the southeast island, which is well correlated with the possible magma reservoir location from previous geophysical and geological surveys. An increasing trend of two-decade LST time series is revealed from all three thermal sensors. The retrieved surface thermal pattern shows non-linear temperature variations that imply the non-steady-state nature of the subsurface thermal sources at this volcano. In summary, satellite LST observations facilitate the understanding on the subsurface magmatic processes of active volcanoes for further management of geothermal resources.
The interactive relationship between ecological well-being performance and tourism economic development in major tourism cities in China
Authors: Lin Feiyang , Huang Chengkun , Zhang Xuan , Chu Deping 
Published: July 2023

Abstract
With the advent of mass tourism, the tourism industry has experienced unprecedented expansion in scale. The relationship between the tourism industry and ecology and society is a key issue in promoting sustainable development of tourist destinations. However, existing research has focused more on the relationship between ecological environment protection and tourism economic development, while neglecting the impact on human well-being in this process. Therefore, based on the concept of ecological welfare, this study explored the coupling coordination degree (CCD) and interaction relationship between the tourism economy development (TED) and ecological wel-being performance (EWP) of 58 major tourism cities in China, providing a more inclusive theoretical perspective and enriching the theory of sustainable tourism and ecological tourism. The results show that: (1) from 2004 to 2019, the EWP and TED of major tourism cities in China showed a steady upward trend. The improvement level of TED was more significant than that of EWP. (2) The CCD between EWP and TED of most tourism cities in China has been improved to varying degrees during the period from 2004 to 2019, especially in many inland tourism cities. (3) There is a dynamic interaction relationship between EWP and TED in major tourism cities in China during the research period, but a virtuous interaction has not yet been formed between the two. The results of this study can also provide practical insights for the sustainable development of urban tourism industry.
Specialized Pro-resolving Mediator Improves Vascular Relaxation via Formyl Peptide Receptor-2
Authors: Edwards-Glenn Jonnelle M , Fontes Milene T , Waigi Emily W , Costa Tiago J , Maiseyeu Andrei , Webb R Clinton , McCarthy Cameron G , Wenceslau Camilla F 
Published: July 2023

AbstractBACKGROUNDThe resolution of inflammation is an active phenomenon important for switching off inflammatory processes once the harmful stimuli are removed and facilitate the return to homeostasis. Specialized pro-resolving mediators (SPMs), such as lipoxin A4, resolvin D1, and resolvin E1, derived from ω-3 or ω-6 polyunsaturated fatty acids, are crucial for the resolution of inflammation. We hypothesized that SPMs are decreased in hypertension which contributes to the acetylcholine-induced contraction in resistance arteries, which are well known to be mediated by leukotrienes and prostaglandins. Moreover, treatment with SPMs will decrease this contraction via formyl peptide receptor-2 (FPR-2) in resistance arteries from spontaneously hypertensive rats (SHR).METHODS AND RESULTSWe performed a comprehensive eicosanoid lipid panel analysis, and our data showed for the first time that precursors of SPMs are decreased in SHR, limiting the production of SPMs and resolution of inflammation in vivo. This phenomenon was associated with an increase in lipid peroxidation in resistance arteries. Although SPMs did not abolish acetylcholine-induced contraction, these lipid mediators improved endothelial function in arteries from SHR via FPR-2 activation at nanomolar concentrations. SPMs also buffered TNF-α-induced reactive oxygen species generation in endothelial cells from C57Bl/6 mice.CONCLUSIONSWe suggest that FPR-2 and SPMs could be revealed as a new target or therapeutic agent to improve vascular function in arteries from hypertensive rats.
A comprehensive genus-level phylogeny and biogeographical history of the Lythraceae based on whole plastome sequences
Authors: Inglis Peter W , Cavalcanti Taciana B , Facco Marlon G , Bakker Freek T , Graham Shirley A 
Published: July 2023

Abstract

Background and Aims
The Lythraceae are a mainly subtropical to tropical family of the order Myrtales with 28 currently accepted genera and approximately 600 species. There is currently no well-supported phylogenetic and biogeographical hypothesis of the Lythraceae incorporating all currently accepted genera, which we sought to provide.

Methods
Plastomes of representative species of 18 distinct Lythraceae genera were sequenced and annotated. Together with existing sequences, plastomes of all 28 currently accepted genera in the Lythraceae were brought together for the first time. The plastomes were aligned and a Bayesian phylogenetic hypothesis was produced. We then conducted a time-calibrated Bayesian analysis and a biogeographical analysis.

Key Results
Plastome-based Bayesian and maximum-likelihood phylogenetic trees are generally congruent with recent nuclear phylogenomic data and resolve two deeply branching major clades in the Lythraceae. One major clade concentrates shrubby and arboreal South American and African genera that inhabit seasonally dry environments, with larger, often winged seeds, adapted to dispersal by the wind. The second major clade concentrates North American, Asian, African and several near-cosmopolitan herbaceous, shrubby and arboreal genera, often inhabiting humid or aquatic environments, with smaller seeds possessing structures that facilitate dispersal by water.

Conclusions
We hypothesize that the Lythraceae dispersed early in the Late Cretaceous from South American to North American continents, with subsequent expansion in the Late Cretaceous of a North American lineage through Laurasia to Africa via a boreotropical route. Two later expansions of South American clades to Africa in the Palaeocene and Eocene, respectively, are also hypothesized. Transoceanic dispersal in the family is possibly facilitated by adaptations to aquatic environments that are common to many extant genera of the Lythraceae, where long-distance dispersal and vicariance may be invoked to explain several remarkable disjunct distributions in Lythraceae clades.
The Training and Application of Silicone Products in Eyebrow Transplantation Simulation
Authors: Xiong Tingfeng , Ou Yangze , Guo Lei , Zhan Taiguo 
Published: July 2023

Abstract

Background
Because the structure of eyebrows is complicated, students need a lot of practice to become familiar with the distribution pattern of eyebrow hair.

Objectives
The current study was designed to investigate training methods for eyebrow design and planting practice before eyebrow hair transplantation to improve planting quality.

Methods
Twelve surgical students were selected. The 6 students in the experimental group had never performed eyebrow transplantation surgery, whereas the 6 in the control group had experience of the procedure. Students in both groups received theoretical and simulated eyebrow hair transplantation instruction. Students were required to master standard eyebrow transplantation. The results of the experimental group and the control group were compared before and after training.

Results
The results revealed that the overall results of the experimental and control groups significantly improved compared with before training (P &lt; .05). After theoretical training, 2-dimensional simulation training, and 3-dimensional simulation training, eyebrow shape, symmetry, hair angle, and density after the 3-dimensional simulation training were statistically significantly improved (P &lt; .05). There was no statistically significant difference, and the students in the control group did not demonstrate any improvement in their capacity to arrange the eyebrows or shape them symmetrically. After training, however, the angle and density of the hair substantially improved.

Conclusions
The experimental group's technical ability in simulated eyebrow planting significantly improved. The present study demonstrated that the students could develop their skills and get closer to the level of surgeons with experience in eyebrow transplant surgery by integrating theoretical lectures with practiced procedures.
O2L-001, an innovative thrombolytic to evacuate intracerebral haematoma
Authors: Thiebaut Audrey M , Louet Estelle R , Ianszen Mélina , Guichard Marie-Julie , Hanley Daniel F , Gaudin Christophe , Parcq Jérôme 
Published: July 2023

Abstract
Intracerebral haemorrhage is an unmet medical need affecting more than 3 million people worldwide every year and leading to the formation of an intracerebral haematoma. Updated guidelines (2022) for the management of intracerebral haemorrhage patients recognize that minimally invasive approaches for the evacuation of supratentorial intracerebral haemorrhage have demonstrated reductions in mortality compared with medical management alone. However, improvement of functional outcome with a procedure involving thrombolytic therapy was neutral in the last large phase 3 clinical trial and requires a more effective and safer thrombolytic agent than those currently available. Here, we demonstrate that O2L-001 allows for the extended release of W253R/R275S recombinant tissue-type plasminogen activator (rtPA). A new rtPA variant, called optimized tPA (OptPA), offers improved efficacy for haematoma evacuation as well as improved safety.
OptPA was produced in a Chinese hamster ovary cell line before purification, nanoprecipitation using the NANOp2Lysis® technological platform followed by suspension in a solution of 17% poloxamer 407 to obtain O2L-001. Plasmin generation assays were performed to demonstrate O2L-001 safety. Ex vivo haematoma models using human blood were used to demonstrate O2L-001 thrombolysis properties and efficacy. For the best translational significance, a clinical sized haematoma was used to ensure catheter placement and to allow administration of the thrombolytic agent into the core of the haematoma via a minimally invasive procedure.
The capacity of OptPA to convert plasminogen into plasmin is strongly decreased compared to rtPA, thereby reducing potential bleeding events. However, a clot lysis assay showed that OptPA had the same fibrinolytic activity as rtPA. We demonstrated that long-term exposure to a thrombolytic agent was essential to achieve high thrombolysis efficacy. Indeed, 24 h continuous exposure to 0.1 µg/ml rtPA had similar efficacy than repeated short exposure to 30 µg/ml rtPA.
This finding led to the development of O2L-001, allowing the extended release of OptPA in the first 6 h following injection. An ex vivo model using human blood was used to demonstrate O2L-001 efficacy. Interestingly, unlike rtPA, O2L-001 was able to induce the complete lysis of the 5 ml haematoma. In clinical sized haematomas (obtained from 30 ml of human blood), a single injection of O2L-001 at 1 mg/ml into the core of the haematoma led to a 44% increase in thrombolysis compared to rtPA.
Taken together, these results demonstrate that O2L-001 provides new hope for haematoma evacuation and the treatment of patients with intracerebral haemorrhage.
Ultra-early myocardial calcification secondary to fulminant myocarditis with 4 years of follow-up: a case report
Authors: You Binquan , Zeng Congjun , Wang Bingyin 
Published: July 2023

Abstract

Background
Early myocardial calcifications secondary to fulminant myocarditis (FM) are rare, and their natural evolution and effects on cardiac function are poorly understood. Here, we followed the patient for 4 years to observe the development of cardiac calcification and its impact on heart function.

Case summary
A 16-year-old man was hospitalized with a fever and cough for 1 day. The patient was previously healthy and had no history of heart disease or specific family conditions. The patient was positive for anti-Epstein–Barr virus IgG and IgM. The computed tomography (CT) scan showed no coronary lesions. Cardiogenic shock and recurrent ventricular fibrillation developed on the third day after admission, and the patient received rescue therapy such as endotracheal intubation, defibrillation, extracorporeal membrane oxygenation, and corticosteroids. On the 13th day of admission, a CT scan revealed significant calcification in the left ventricular wall. The patient was discharged after 30 days in the hospital. After discharge, his left ventricular calcification peaked at 6 months and gradually subsided after that, and his left ventricular function slowly returned to normal at 12 months.

Discussion
In younger patients, myocardial calcifications secondary to FM may occur as early as 13 days and affect cardiac function. After proper treatment and rehabilitation, the patient’s myocardial calcification can gradually subside and the cardiac function can gradually recover. For FM patients, timely and comprehensive intensive treatment, including heart, lung, and kidney replacement therapy and early administration of hormone preparations, may be beneficial to the early recovery of patients.
Diagnostic and therapeutic pathways for the malignant left atrial appendage: European Heart Rhythm Association physician survey
Authors: Anic Ante , Bakovic Darija , Jurisic Zrinka , Farkowski Michal , Lisica Lucija , Breskovic Toni , Nielsen-Kudsk Jens Erik , Perrotta Laura , de Asmundis Carlo , Boveda Serge , Chun Julian 
Published: July 2023

AbstractAimsPatients with atrial fibrillation who despite taking oral anti-coagulant therapy (OAT) suffer a stroke or systemic embolism (SSE) without vascular cause or who develop left atrial appendage (LAA) thrombus (LAAT) should be considered as having malignant LAA. The optimal treatment strategy to reduce SSE risk in such patients is unknown. The aim of the study is to investigate the diagnostic and therapeutic pathways for malignant LAA practiced in European cardiac centres.Methods and resultsAn 18-item online questionnaire on malignant LAA was disseminated by the European Heart Rhythm Association (EHRA) Scientific Initiatives Committee. A total of 196 physicians participated in the survey. There seems to be high confidence in transoesophageal echocardiography (TEE) imaging, considering LAAT diagnosis. Switching to another direct oral anti-coagulant (DOAC) is the preferred initial step for the treatment of malignant LAA followed by a switch to vitamin K antagonist (VKA), low-molecular-weight heparin, or continued/optimized DOAC dosage, whereas LAA closure is the last option. Left atrial appendage closure is a viable option in patients with embolic stroke despite OAT and no evidence of thrombus at TEE (empty LAA) after comprehensive diagnostic measures to exclude other sources of embolism.ConclusionThis EHRA survey provides a snapshot of the contemporary management of patients diagnosed with malignant LAA. Currently, the majority of patients are treated on an outpatient basis with either shifting from VKA to DOAC or from one DOAC to another. Left atrial appendage closure in this population seems to be reserved for patients with higher bleeding risk or complications of malignant LAA, such as stroke.