bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Wooden Home Enabled by Direct‐Written Laser‐Induced Graphene
Authors: Nam Han Ku , Le Truong‐Son Dinh , Yang Dongwook , Kim Byunggi , Lee Younggeun , Hwang June Sik , Kim Young‐Ryeul , Yoon Hana , Kim Seung‐Woo , Kim Young‐Jin 
Published: January 2023

AbstractWood is a naturally abundant, renewable, recyclable, biodegradable, and environment‐friendly construction material. Smart homes capable of remote monitoring and light, climate, and appliance control require a large number of electrical sensors and interconnections, which are challenging to implement in wood. Although conductive Laser‐induced‐graphene (LIG) formation on lignocellulosic materials has been lately reported, the introduction of LIG electrodes to smart wooden home applications has not been addressed to date. Herein, the direct patterning of LIG on natural wood in atmospheric air to form key electrical components that can support the construction of smart wooden homes is demonstrated. The sheet resistance of the LIG can reach 6.0 Ω sq−1, which is sufficient to support smart home requirements. Four key smart home components, namely, a temperature sensor, heater, boiler, and electrical interconnections, are successfully patterned on wood at room temperature without significant ablation. In consideration of the real‐world application of this technology to wooden buildings, varnish coating is used for the LIG's structural protection; all the tests are conducted repeatedly by considering the actual wooden smart home applications. The design of LIG electrical connections using an external mechanical pressure without conductive adhesives will help promote the development of green and smart adhesive‐free timber‐based buildings.
Achieving High‐Performance Triboelectric Nanogenerator by DC Pump Strategy
Authors: Yang Peiyuan , Zhou Linglin , Gao Yikui , Xiao Junfeng , Liu Di , Zhao Zhihao , Qiao Wenyan , Liu Jiaqi , Wang Zhong Lin , Wang Jie 
Published: January 2023

AbstractTriboelectric nanogenerator (TENG) has been demonstrated as a promising solution for powering widely distributed electronics in the new era of Internet of Things (IoTs), however, high‐performance TENG always relies on tribo‐materials with high triboelectric property. Herein, a simple self‐charge excitation technique that charge injection is directly realized by self‐generated electrostatic breakdown charge instead of voltage‐multiplying circuit is proposed to break through the limitation of triboelectrification. By using the designed electrostatic breakdown charge excitation TENG (EBE‐TENG), the output performance of poor tribo‐material based TENG such as polyethylene (PE) can be enhanced by 5.7 times, which even approximates that of high tribo‐material based TENG such as fluorinated ethylene propylene (FEP). Moreover, electrostatic breakdown charge excitation technique also exhibits a universal applicable ability for other different triboelectric materials. This work not only greatly simplifies the charge excitation system, but also broadens the availability of materials for achieving high‐performance TENG.
[1,2]‐Phospha‐Brook Rearrangement as Tool for Generation of Anionic Nucleophiles in Addition Reactions under Brønsted Base Catalysis
Authors: Kondoh Azusa , Terada Masahiro 
Published: January 2023

AbstractThe [1,2]‐phospha‐Brook rearrangement involves the migration of the dialkoxyphosphoryl moiety of the alkoxide of an α‐hydroxyphosphonate from carbon to oxygen to generate an α‐oxygenated carbanion. The alkoxide that is the precursor for the rearrangement is easily accessible by the deprotonation of α‐hydroxyphosphonates or the addition of the anion of secondary phosphites to carbonyl compounds under the influence of a Brønsted base. This review article summarized recent development of the Brønsted base‐catalyzed addition reactions in which the [1,2]‐phospha‐Brook rearrangement is utilized for the generation of carbon‐based anionic nucleophiles.
A Primer on Luminescence Sensing
Authors: Gorris Hans H. , Farka Zdeněk , Hildebrandt Niko 
Published: January 2023

AbstractThis Perspective provides a concise overview of the field of Luminescence Sensing, which enables highly sensitive, selective, and versatile measurements. The emergence of new luminescent nanomaterials and the prospective of deploying new luminescence‐based detection schemes for solving real‐world problems, e. g., in medical diagnosis, food safety, and environmental sciences, has led to a continuous growth of the field over recent years. The contributions to the Special Collection on Luminescence Sensing – with a focus on the versatility and advantages of lanthanide complexes for advanced biosensing – serve as an excellent foundation to highlight and discuss recent developments and challenges.
Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic‐Refractory Lyme Arthritis
Authors: Sanes Jurgen T. , Costello Catherine E. , Steere Allen C. 
Published: January 2023

ObjectiveTerminal glycans on the Fc portion of IgG antibodies are critical for antibody‐triggered, proinflammatory or antiinflammatory responses. We undertook this study to compare glycan profiles of total IgG1 and Borrelia burgdorferi (Bb)–specific IgG1 antibodies in patients with oral antibiotic–responsive or antibiotic‐refractory Lyme arthritis (LA).MethodsFollowing affinity‐column processing, glycan profiles of IgG antibodies were determined in serum and synovial fluid (SF) samples of 21 LA patients using glycoblotting with hydrazide glycan enrichment and determination of glycan structure by matrix‐assisted laser desorption ionization–time‐of‐flight mass spectrometry. Correlations between glycan profiles and treatment outcomes were analyzed.ResultsCompared with patients with antibiotic‐refractory LA, those with antibiotic‐responsive LA had total and Bb‐specific IgG1 antibody glycans with less intense inflammatory profiles, containing lower percentages of N‐acetylglucosamine (GlcNAc) and bisecting GlcNAc and higher percentages of galactose and fucose. In contrast, patients with antibiotic‐refractory LA prior to receiving IV antibiotic therapy had total IgG1 and Bb IgG1 antibodies with maximal, minimally opposed, proinflammatory glycan profiles, containing high percentages of GlcNAc and bisecting GlcNAc, intermediate percentages with galactose and fucose, and low percentages with N‐acetylneuraminic acid (sialic acid). Patients with refractory LA who were first seen with synovitis after receiving IV antibiotic therapy still had Bb IgG1 antibodies with strongly inflammatory glycan profiles, but their inflammatory potential appeared to be waning.ConclusionPatients with oral antibiotic–responsive LA had Bb IgG1 antibodies with more balanced proinflammatory/antiinflammatory glycan profiles, whereas patients with antibiotic‐refractory LA had Bb IgG1 antibodies with maximal, minimally opposed, proinflammatory glycan profiles. Among patients with antibiotic‐refractory LA, antibodies with this unbalanced inflammatory glycan profile may have a role in sustaining maladaptive joint inflammation.
Systematic Study of Podand Molecules for Synergistic Halogen and Hydrogen Bond‐Driven Anion Recognition in the Solid State
Authors: Saccone Marco , Cametti Massimo , Metrangolo Pierangelo , Pilati Tullio , Resnati Giuseppe , Terraneo Giancarlo 
Published: January 2023

AbstractThe increasing demand of species for the efficient capture and sensing of anions benefits from a systematic study of anion binding capabilities in the solid state. This work reports a detailed crystallographic study of ten structurally related podands and shows that these charged receptors bind anions with a combination of charge‐assisted halogen and hydrogen bonds. Computational tools helped in highlighting the role of the different involved interaction and afforded possible design principles for the design of improved podands.
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation
Authors: Sarnobat Dipak , Moffett R. Charlotte , Ma Jinfang , Flatt Peter R. , McClenaghan Neville H. , Tarasov Andrei I. 
Published: January 2023

AbstractThe semi‐essential ubiquitous amino acid taurine has been shown to alleviate obesity and hyperglycemia in humans; however, the pathways underlying the antidiabetic actions have not been characterized. We explored the effect of chronic taurine exposure on cell biology of pancreatic islets, in degenerative type 1‐like diabetes. The latter was modeled by small dose of streptozotocin (STZ) injection for 5 days in mice, followed by a 10‐day administration of taurine (2% w/v, orally) in the drinking water. Taurine treatment opposed the detrimental changes in islet morphology and β‐/α‐cell ratio, induced by STZ diabetes, coincidentally with a significant 3.9 ± 0.7‐fold enhancement of proliferation and 40 ± 5% reduction of apoptosis in β‐cells. In line with these findings, the treatment counteracted an upregulation of antioxidant (Sod1, Sod2, Cat, Gpx1) and downregulation of islet expansion (Ngn3, Itgb1) genes induced by STZ, in a pancreatic β‐cell line. At the same time, taurine enhanced the transdifferentiation of α‐cells into β‐cells by 2.3 ± 0.8‐fold, echoed in strong non‐metabolic elevation of cytosolic Ca2+ levels in pancreatic α‐cells. Our data suggest a bimodal effect of dietary taurine on islet β‐cell biology, which combines the augmentation of α‐/β‐cell transdifferentiation with downregulation of apoptosis. The dualism of action, stemming presumably from the intra‐ and extracellular modality of the signal, is likely to explain the antidiabetic potential of taurine supplementation.
NIR‐II absorbing organic nanoagents for photoacoustic imaging and photothermal therapy
Authors: Shao Wei , Zhao Fulai , Xue Jinhong , Huang Lingling 
Published: January 2023

AbstractNear‐infrared (NIR) absorbing materials hold great potential in biomedical applications, such as fluorescence imaging (FLI), photoacoustic imaging (PAI), photodynamic therapy (PDT), and photothermal therapy (PTT). Generally, these materials can be classified into two main categories based on their absorbing wavelengths: the first NIR (NIR‐I) (~650–950 nm) absorbing materials and the second NIR (NIR‐II) (~1000–1700 nm) absorbing materials. Due to the reduced absorption and scattering of NIR‐II light in tissue compared to NIR‐I light, NIR‐II absorbing materials enable imaging and therapy with improved contrast and deepened penetration, which is in favor of practical applications. Various inorganic materials have been developed for NIR‐II phototheranostics in recent years. However, the non‐biodegradability and potential toxicity of these materials hinder their further clinical translation. Biocompatible organic materials with potential biodegradability as well as tailored optical property are thus more desired. In this review, we summarize the recent advances of NIR‐II absorbing organic nanoagents (ONAs) based on small molecules (SMs) and conjugated polymers (CPs) for PAI and PTT and show our perspectives on future challenges and development of these materials.
Metabolic study of new psychoactive substance methoxpropamine in mice by UHPLC‐QTOF‐HRMS
Authors: Massano Marta , Gerace Enrico , Borsari Martina , Marti Matteo , Tirri Micaela , Ververi Christina , Alladio Eugenio , Vincenti Marco , Salomone Alberto 
Published: January 2023

AbstractMethoxpropamine (MXPr) is an arylcyclohexylamine dissociative drug structurally similar to 3‐methoxyeticyclidine, ketamine, and deschloroketamine, recently appeared in the European illegal market, and was classified within the new psychoactive substances (NPS). Our study investigated the metabolism of MXPr to elucidate the distribution of the parent drug and its metabolites in body fluids and fur of 16 mice. After the intraperitoneal administration of MXPr (1, 3, and 10 mg/kg), urine samples from eight male and eight female mice were collected every hour for six consecutive hours and then at 12‐ to 24‐h intervals. Additionally, plasma samples were collected 24 h after MXPr (1 and 3 mg/kg) administration. Urine and plasma were diluted 1:3 with acetonitrile/methanol (95:5) and directly injected into the UHPLC‐QTOF‐HRMS system. The phase‐I and phase‐II metabolites were preliminarily identified by means of the fragmentation patterns and the exact masses of both their precursor and fragment ions. Lastly, the mice fur was analyzed following an extraction procedure specific for the keratin matrix. Desmethyl‐MXPr‐glucoronide was identified in urine as the main metabolite, detected up to 24 h after administration. The presence of norMXPr in urine, plasma, and fur was also relevant, following a N‐dealkylation process of the parent drug. Other metabolites that were identified in fur and plasma included desmethyl‐MXPr and dihydro‐MXPr. Knowledge of the MXPr metabolites evolution is likely to support their introduction as target compounds in NPS toxicological screening analysis on real samples, both to confirm intake and extend the detection window of the dissociative drug MXPr in the biological matrices.
Environmental DNA (eDNA) reveals potential for interoceanic fish invasions across the Panama Canal
Authors: Schreiber Lennart , Castellanos‐Galindo Gustavo A. , Robertson D. Ross , Torchin Mark , Chavarria Karina , Laakmann Silke , Saltonstall Kristin 
Published: January 2023

AbstractInteroceanic canals can facilitate biological invasions as they connect the world's oceans and remove dispersal barriers between bioregions. As a consequence, multiple opportunities for biotic exchange arise and the resulting establishment of migrant species often causes adverse ecological and economic impacts. The Panama Canal is a key region for biotic exchange as it connects the Pacific and Atlantic Oceans in Central America. In this study, we used two complementary methods (environmental DNA (eDNA) metabarcoding and gillnetting) to survey fish communities in this unique waterway. Using COI (cytochrome oxidase subunit I) metabarcoding, we detected a total of 142 fish species, including evidence for the presence of sixteen Atlantic and eight Pacific marine fish in different freshwater sections of the Canal. Of these, nine are potentially new records. Molecular data did not capture all species caught with gillnets, but generally provided a more complete image of the known fish fauna as more small‐bodied fish species were detected. Diversity indices based on eDNA surveys revealed significant differences across different sections of the Canal reflecting in part the prevailing environmental conditions. The observed increase in the presence of marine fish species in the Canal indicates a growing potential for interoceanic fish invasions. The potential ecological and evolutionary consequences of this increase in marine fishes are not only restricted to the fish fauna in the Canal as they could also impact adjacent ecosystems in the Pacific and Atlantic Oceans.
Mimicking orchids lure bees from afar with exaggerated ultraviolet signals
Authors: Scaccabarozzi Daniela , Lunau Klaus , Guzzetti Lorenzo , Cozzolino Salvatore , Dyer Adrian G. , Tommasi Nicola , Biella Paolo , Galimberti Andrea , Labra Massimo , Bruni Ilaria , Pattarini Giorgio , Brundrett Mark , Gagliano Monica 
Published: January 2023

AbstractFlowers have many traits to appeal to pollinators, including ultraviolet (UV) absorbing markings, which are well‐known for attracting bees at close proximity (e.g., <1 m). While striking UV signals have been thought to attract pollinators also from far away, if these signals impact the plant pollinia removal over distance remains unknown. Here, we report the case of the Australian orchid Diuris brumalis, a nonrewarding species, pollinated by bees via mimicry of the rewarding pea plant Daviesia decurrens. When distant from the pea plant, Diuris was hypothesized to enhance pollinator attraction by exaggeratedly mimicking the floral ultraviolet (UV) reflecting patterns of its model. By experimentally modulating floral UV reflectance with a UV screening solution, we quantified the orchid pollinia removal at a variable distance from the model pea plants. We demonstrate that the deceptive orchid Diuris attracts bee pollinators by emphasizing the visual stimuli, which mimic the floral UV signaling of the rewarding model Daviesia. Moreover, the exaggerated UV reflectance of Diuris flowers impacted pollinators' visitation at an optimal distance from Da. decurrens, and the effect decreased when orchids were too close or too far away from the model. Our findings support the hypothesis that salient UV flower signaling plays a functional role in visual floral mimicry, likely exploiting perceptual gaps in bee neural coding, and mediates the plant pollinia removal at much greater spatial scales than previously expected. The ruse works most effectively at an optimal distance of several meters revealing the importance of salient visual stimuli when mimicry is imperfect.
Interfacial structure and strength of Al‐25Si‐4Mg‐1Cu joint brazed with Zn interlayer
Authors: Ma Qiang , Chen Yongwei , Li Shengguo , Xu Guo , Wang Fengjiang , He Peng , Zhang Shuye 
Published: January 2023

AbstractA high‐quality joint of the parent metal Al‐25Si‐4Mg‐1Cu alloy (AlSi alloy) was brazed to itself using Zn layer as a filler material. The typical microstructure of AlSi/Zn/AlSi joint was Al‐Zn solid solution, primary Si phase and α‐Al phase. When brazing temperature was increased from 400 to 405°C, Zn began to melt and reacted with Al diffused from base material, then Si phase formed. While the increase in brazing temperature to 415°C caused the gradual buring of Zn from Al‐Zn solid solution, and α‐Al remained. Furthermore, the shear strength of the joint increased because of α‐Al phase and Si phase formation. In addition, with brazing time extending from 8 to 12 min, the amount of Al‐Zn solid solution decreased, while the amount of Si phase and α‐Al phase increased, thus the shear strength of the joint was improved. While the increase in holding time extending to 14 min caused many micro‐voids formed, and the shear strength of the joint was reduced. Finally, the shear strength of the joint brazed at 415°C for 12 min reached 65.6 MPa.
Geophysical–geotechnical methodology for assessing the spatial distribution of glacio‐lacustrine sediments: The case history of Lake Seracchi
Authors: Vergnano Andrea , Oggeri Claudio , Godio Alberto 
Published: January 2023

AbstractProglacial lakes are distinctive features of deglaciated landscapes and often act as sediment sinks, collecting solid material from subglacial erosion or washout of deglaciated areas. The solid transport flow, strongly linked to the glaciers and periglacial landforms, may rise due to the rapid changes driven by climate warming, causing deep transformations in the basin hydrology, and even the appearance or disappearance of lakes at a decadal timescale.The goal of this study was to present a geophysical–geotechnical approach that integrates several techniques, to quantify the sediment distribution in a proglacial lake. A geophysical survey is performed with ground‐penetrating radar (GPR) installed on a boat, whereas a time‐domain reflectometer (TDR) measures the electrical conductivity and permittivity of the lakebed sediments. Unperturbed samples are collected and analyzed to measure the main geotechnical properties of the sediment: grain‐size distribution, plastic limit, and liquid limit. Such properties support the interpretation of the GPR data and the detection of spatial variations of the sediment facies.To validate the proposed methodology, field tests were carried out at Lake Seracchi, the largest lake of the Rutor glacier, Italian Alps. It formed around 1880 because of the recent glacier shrinkage, as chronicled by valuable historical documents. Its greyish waters carry a significant amount of suspended sediment recognized as glacial flour, which gradually accumulates on the bottom of the lake.The obtained bathymetry and sediment thickness maps of Lake Seracchi show the strength of the approach: from only a few manual samples, it is possible to extrapolate the geotechnical properties of interest, such as friction angle or hydraulic conductivity, to wider areas, surveyed by the geophysical techniques. This is achieved by investigating the spatial distribution of key geophysical properties linked to the geotechnical properties of interest.
Evaluation of Complex Mixture Toxicity in the Milwaukee Estuary (WI, USA) Using Whole-Mixture and Component-Based Evaluation Methods
Authors: Maloney Erin M. , Villeneuve Daniel L. , Jensen Kathleen M. , Blackwell Brett R. , Kahl Michael D. , Poole Shane T. , Vitense Kelsey , Feifarek David J. , Patlewicz Grace , Dean Kendra , Tilton Charlene , Randolph Eric C. , Cavallin Jenna E. , LaLone Carlie A. , Blatz Donovan , Schaupp Christopher M. , Ankley Gerald T. 
Published: January 2023

Abstract
Anthropogenic activities introduce complex mixtures into aquatic environments, necessitating mixture toxicity evaluation during risk assessment. There are many alternative approaches that can be used to complement traditional techniques for mixture assessment. Our study aimed to demonstrate how these approaches could be employed for mixture evaluation in a target watershed. Evaluations were carried out over 2 years (2017–2018) across 8–11 study sites in the Milwaukee Estuary (WI, USA). Whole mixtures were evaluated on a site-specific basis by deploying caged fathead minnows (Pimephales promelas) alongside composite samplers for 96 h and characterizing chemical composition, in vitro bioactivity of collected water samples, and in vivo effects in whole organisms. Chemicals were grouped based on structure/mode of action, bioactivity, and pharmacological activity. Priority chemicals and mixtures were identified based on their relative contributions to estimated mixture pressure (based on cumulative toxic units) and via predictive assessments (random forest regression). Whole mixture assessments identified target sites for further evaluation including two sites targeted for industrial/urban chemical mixture effects assessment; three target sites for pharmaceutical mixture effects assessment; three target sites for further mixture characterization; and three low-priority sites. Analyses identified 14 mixtures and 16 chemicals that significantly contributed to cumulative effects, representing high or medium priority targets for further ecotoxicological evaluation, monitoring, or regulatory assessment. Overall, our study represents an important complement to single-chemical prioritizations, providing a comprehensive evaluation of the cumulative effects of mixtures detected in a target watershed. Furthermore, it demonstrates how different tools and techniques can be used to identify diverse facets of mixture risk and highlights strategies that can be considered in future complex mixture assessments. Environ Toxicol Chem 2023;42:1229–1256. © 2023 SETAC