bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Biological Characteristics of Eutopic and Ectopic Endometrial
Progenitor Cells in Endometriosis
Authors: Zhang Qingxia , Liang Jing , Xu Dongkui , Gao Ting , Zhang Jinku , Liang Haiyan , Wang Wenhui , Ling Bin , Feng Dingqing 
Published: February 2023

Aim:
The aim of this study was to identify the biological characteristics and potential roles of
endometrial progenitor cells in the pathogenesis of endometriosis.

Background:
It is generally believed that progenitor cells in human endometrium are responsible for
rapid endometrial regeneration. However, the biological characteristics and potential roles of the paired
eutopic and ectopic endometrial progenitor cells in endometriosis remain unclear.

Objective:
This study intends to isolate the epithelial progenitor (EP) cells and endometrial mesenchymal
stem cells (eMSCs) from the eutopic and ectopic endometria from endometriosis patients, further to
reveal their features and functions respectively.

Methods:
The distributions of EP cells and eMSCs and the expression of steroid hormone receptors in the
endometrium and endometriotic tissues were assessed by immunohistochemistry. EP cells and eMSCs were
sorted from paired eutopic and ectopic endometria with epithelial cell adhesion molecule (EpCAM) magnetic
beads. The clonogenicity, cell viability after being treated with estradiol and progesterone, and cell markers
expression were evaluated with colony forming on Matrigel, CCK-8 and immunofluorescence staining,
respectively. The differentially expressed genes (DEGs) were further identified with RNA sequencing.

Results:
SSEA-1- and PDGFRβ-positive cells were distributed in the epithelial and stromal layers. The
ERβ staining was much more intense in endometriotic tissues, but PR expression was almost absent. The
ectopic EP cells exhibit strong clonogenicity and ERβ expression but weak PR expression, leading to
progesterone resistance. There are 12604 and 13242 DEGs revealed by RNA sequencing between eutopic
and ectopic EP cells or eMSCs. GO and KEGG analyses revealed that the functions and pathways of
DEGs enriched in cellular energy metabolism and regulation of the immune response, respectively. Additionally,
ERβ targets were mainly enriched in ectopic EP cells.

Conclusion:
Both EP cells and eMSCs may engage in ectopic lesion formation in endometriosis by modifying
the metabolic mode and immune tolerance. These data not only help to understand the molecular
mechanism of endometriosis but also could potentially contribute to the discovery of therapeutic targets
for endometriosis.
How Does ChatGPT Perform on the United States Medical Licensing Examination (USMLE)? The Implications of Large Language Models for Medical Education and Knowledge Assessment
Authors: Gilson Aidan , Safranek Conrad W , Huang Thomas , Socrates Vimig , Chi Ling , Taylor Richard Andrew , Chartash David 
Published: February 2023

Background
Chat Generative Pre-trained Transformer (ChatGPT) is a 175-billion-parameter natural language processing model that can generate conversation-style responses to user input.

Objective
This study aimed to evaluate the performance of ChatGPT on questions within the scope of the United States Medical Licensing Examination (USMLE) Step 1 and Step 2 exams, as well as to analyze responses for user interpretability.

Methods
We used 2 sets of multiple-choice questions to evaluate ChatGPT’s performance, each with questions pertaining to Step 1 and Step 2. The first set was derived from AMBOSS, a commonly used question bank for medical students, which also provides statistics on question difficulty and the performance on an exam relative to the user base. The second set was the National Board of Medical Examiners (NBME) free 120 questions. ChatGPT’s performance was compared to 2 other large language models, GPT-3 and InstructGPT. The text output of each ChatGPT response was evaluated across 3 qualitative metrics: logical justification of the answer selected, presence of information internal to the question, and presence of information external to the question.

Results
Of the 4 data sets, AMBOSS-Step1, AMBOSS-Step2, NBME-Free-Step1, and NBME-Free-Step2, ChatGPT achieved accuracies of 44% (44/100), 42% (42/100), 64.4% (56/87), and 57.8% (59/102), respectively. ChatGPT outperformed InstructGPT by 8.15% on average across all data sets, and GPT-3 performed similarly to random chance. The model demonstrated a significant decrease in performance as question difficulty increased (P=.01) within the AMBOSS-Step1 data set. We found that logical justification for ChatGPT’s answer selection was present in 100% of outputs of the NBME data sets. Internal information to the question was present in 96.8% (183/189) of all questions. The presence of information external to the question was 44.5% and 27% lower for incorrect answers relative to correct answers on the NBME-Free-Step1 (P<.001) and NBME-Free-Step2 (P=.001) data sets, respectively.

Conclusions
ChatGPT marks a significant improvement in natural language processing models on the tasks of medical question answering. By performing at a greater than 60% threshold on the NBME-Free-Step-1 data set, we show that the model achieves the equivalent of a passing score for a third-year medical student. Additionally, we highlight ChatGPT’s capacity to provide logic and informational context across the majority of answers. These facts taken together make a compelling case for the potential applications of ChatGPT as an interactive medical education tool to support learning.
Game Elements in the Design of Simulations in Military Trauma Management Training: Protocol for a Systematic Review
Authors: Stathakarou Natalia , Kononowicz Andrzej A , Swain Cara , Karlgren Klas 
Published: February 2023

Background
Military trauma teams are commonly operating in civilian hospitals during peacetime; in a war situation they must adjust their practices to the austere conditions. Simulations can replicate austere conditions to allow training in a safe environment that tolerates errors. Gamification, understood as the use of game elements to motivate and engage learners in nongame contexts, is gaining interest in medical education and military training. Applying game elements in the design of military trauma management simulations has the potential to provide learners with active learning opportunities and prepare them for providing medical services under austere conditions. Although gamification is known for its engaging and motivational benefits, there are controversies about its pedagogical value. The controversies can be attributed to the fact that various gamification strategies may consist of a different combination of game elements, leading to different outcomes.

Objective
This systematic review aims to understand how game elements are used in the design of simulations in military trauma management training and their reported outcomes.

Methods
We have designed a search strategy for the purpose of the review. Two researchers will independently assess the identified studies based on the defined inclusion and exclusion criteria. The selection process will be represented using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram. The search will be repeated and updated as necessary prior to publication of the review. Two reviewers will independently extract and manage the data for each of the articles using a structured data extraction form. Any disagreement that arises between reviewers will be resolved through discussion, and a third review author will be consulted when needed. We are going to conduct a thematic synthesis of the extracted game element descriptions. The results are going to be presented in a diagrammatic or tabular form, alongside a narrative summary. The quality of the studies will be assessed.

Results
We implemented and tested the developed search strategy in May 2023. We retrieved 1168 study abstracts, which were reduced to 630 abstracts after deduplication. We have piloted the screening on 20% (126/630) of the identified abstracts in groups of 2 reviewers.

Conclusions
Although gamification has the potential to motivate learners in various ways, there is a lack of understanding about specific game elements and how they can inform instructional design in different contexts. Our findings will increase the understanding of how game elements are used in the design of simulations in military trauma management training and, thus, contribute to more effective development of future simulations.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45969
Sistema de salud: garantía institucional del derecho a la protección de la salud en México
Authors: Vargas Ruiz María Magaly 
Published: February 2023

En México, el derecho a la salud está protegido constitucionalmente; impone al Estado una obligación progresiva, sujeta a la capacidad financiera. El sistema de salud es la garantía institucional para su instrumentación; este sistema fue reformado recientemente, el 29 de noviembre de 2019, con objeto de otorgar gratuitamente servicios de salud, medicamentos y demás insumos a la población sin seguridad social, así como para lograr la adecuada integración y articulación de sus instituciones.
El objetivo de este trabajo es analizar el sistema de salud mexicano como responsable de la garantía institucional del derecho a la salud. Para ello, se realizó un análisis legislativo de la reforma a la legislación relacionada con la protección del derecho a la salud, comparado con la inmediata anterior. Resultados. Se encontró que la última reforma del sistema de salud implicaría una importante modificación estructural, así como de sus fuentes de financiamiento; sin embargo, al no modificarse de forma sustancial la organización del sistema de salud, se limita a un cambio normativo influenciado por el contexto político y sus principales actores, más que por la necesidad de garantizar institucionalmente el derecho a la salud hacia la cobertura universal independientemente del estatus laboral o del tipo de ciudadanía. La inclusión de los derechos fundamentales en el ámbito de la salud implica la implementación de políticas públicas dirigidas al acceso universal y equitativo a la salud; sin embargo, la fragmentación del sistema de salud es todavía el principal reto.
Enseñanza de la disciplina histórica escolar desde un enfoque contemporáneo: una propuesta de agendas investigativas desde la Web of Science y Scopus
Authors: Guzmán Contreras Patricio 
Published: February 2023

Las agendas investigativas se caracterizan por ser piezas de investigación agrupadas en un campo específico para comprender una dimensión teórica particular y generar claridad epistemológica de las temáticas. El objetivo de este estudio fue conocer las temáticas investigativas de la enseñanza de la historia desde un enfoque contemporáneo en tres revistas indexadas en Web Of Science (WOS) y una en Scopus, tomando como marco de referencia el código disciplinar de la historia escolar propuesto por Cuesta (1997). Con un enfoque mixto y una muestra aleatoria simple, se analizaron los resúmenes de 60 artículos de revistas publicadas entre 2015 a 2022, poniendo énfasis en las temáticas, preguntas de investigación y metodologías. Las agendas que emergieron fueron: “Prácticas docentes”, “Valoración de la enseñanza de la disciplina histórica”, “Educación para la justicia social”, “Educación basada en el desarrollo de habilidades” y “Características de la disciplina histórica escolar”. Los resultados muestran que la mayor cantidad de artículos agendados están en las revistas Estudios Pedagógicos y British Educational Research Journal, 55 y 42 respectivamente, mientras que New Zealand Journal of Educational Studies es la que presenta menos artículos clasificados, con 13. Las agendas con mayor cantidad de publicaciones son “Prácticas docentes” y “Educación basada en el desarrollo de habilidades”. Respecto a la metodología del corpus de artículos, las mayores cifras se centran en el enfoque cualitativo; solo se encontraron cinco publicaciones con un enfoque cuantitativo; mientras que el método mixto sumó 13 % del total. Por último, todas las agendas contribuyen a comprender la enseñanza de la disciplina histórica escolar desde un enfoque contemporáneo y a desarrollar habilidades para el siglo XXI.
The Relationship between Breastfeeding Education Classes and Breastfeeding for Infants at the Benteng Public Health Center, Nusaniwe District, Ambon City
Authors: Pellaupessy Algraciela , Novita Regina Vidya Trias 
Published: February 2023

Breastfeeding is an activity of providing nutrition for newborns which requires of skills, so they need of accompaniment from health workes to achieve first thousand days of life periode (kemenkes,2016). Based on World Health Organization (2016) fluctuation of exclusive breastfeeding still very far from target of 80%. The purpose of this study to find out about relationship between breastfeeding education classes with mother with toddler breastfeeding at the Benteng health center, Nusaniwe, Ambon City. Correlative descriptive reasearch method with approach cross sectional. The sampling technique use purposive sampling as many as 260 mother who had toddlers. The research sample is mother who had toddler with a sample of 158 respondent. Data collection tools is used form of questionnaire. Data analysis was carried out using chi square test with trusted level a = 0,05. The result of this study were obtained about education classes of Antenal Care most result are who follow education classes (79,1%). Post partum education classes most result are who follow education classes (68,4%). Result for breastfeeding 6 months are (84,8%), result for breastfeeding >6month-1years are (79,7%) and result for breastfeeding >1-2years are (53,8%). The result statistics of Chi Square test showed a significant relationship between Antenal Care education classes with breastfeeding for 6 months (p value 0.012), then there is a significant relationship between Anetal Care education classes with breastfeeding >6month-1years (p value 0.035), nothing relationship between Anetal Care education classes with breastfeeding >1-2years (p value 0.328), nothing relationship between Post Partum education classes with breastfeeding 6 months (p value 0.340), Post partum education classes with breastfeeding >6month-1years (p value 0.832), and Post Partum education classes with breastfeeding >1-2years (p value 1.000).
The Role of Work Motivation Mediation on Workplace Deviant Behavior of Class C Private Hospital at Bekasi
Authors: Widjaja Elsa , Anindita Rina , Indrawati Ratna 
Published: February 2023

Workplace deviant behavior is an important thing that the hospital must pay attention to since it can threaten the organization and employees. Workplace deviant behavior unnoticeable can affect the entire process both in terms of work productivity and organizational profitability. Results of the interviews showed that the organizational climate felt less conducive, and the motivation and reward system was still low. This study aims to analyze the effect of organizational climate and reward system on workplace deviant behavior mediated by simultaneous work motivation. This research is explanatory research with a quantitative approach in the form of hypothetical causalities with a sample of 107 permanent employees, both medical and non-medical. This research uses SEM-PLS method with SmartPLS 3.0 and SPSS version 25 for validity and reliability pretest. This research found that organizational climate has a negative and insignificant effect on workplace deviant behavior, work motivation, and reward system, which have a negative. Meanwhile, a significant effect on workplace deviant behavior and organizational climate, the reward system has a positive and significant impact on work motivation. Organizational climate and reward systems have a negative and significant effect on workplace deviant behavior through work motivation as an intervening variable. The implications of this research theoretically prove that the influence of research variables and managerial will further fix the evaluation system of services in hospitals.
Penerapan Pembauran Ornamen Islam dan Tionghoa Dalam Arsitektur Masjid Muhammad Cheng Hoo
Authors: Adininggar Melati Indira , Kurnia Elvira Dewi , Alfiah Alfiah 
Published: February 2023

Abstrak_ Masyarakat Indonesia pada abad ke 7 Masehi melakukan perdagangan dengan negeri Islam. Interaksi tersebut berpengaruh pada bentuk arsitektur bangunan masjid yang dibangun. Masjid di Indonesia pada umumnya mengadopsi masjid dari Timur Tengah dan ditambah dengan budaya lokal setempat. Tetapi masyarakat keturunan Cina yang beragama islam membangun masjid Muhammad Cheng Ho dengan arsitektur khas Cina. Selain itu, masjid Muhammad Cheng Ho Makassar memiliki bentuk yang unik dan menarik yang berdiri di tengah tengah muslim Makassar yang secara umum memiliki budaya yang berbeda dengan muslim Cina. Sehingga, keberadaan masjid ini sebagai wujud atau simbol dari toleransi antar etnis dan budaya. Konsep arsitektur pada masjid ini merupakan perpaduan antara Islam-Tiongkok dan keunikannya berada pada ragam hias dari masjid yang memiliki makna serta nilai.Kata kunci: Pembauran; Budaya; Masjid. Abstract_Indonesian society in the 7th century AD traded with the Islamic state. These interactions have an effect on the architectural form of the mosque building that was built. Mosques in Indonesia generally adopt mosques from the Middle East and are incorporated with local culture. But the Chinese descendants of Islam who built the Muhammad Cheng Ho mosque with Chinese architecture. In addition, the Muhammad Cheng Ho Mosque in Makassar has a unique and interesting place that stands in the midst of Makassar Muslims who generally have a different culture with Chinese Muslims. So, the existence of this mosque as a form or symbol of tolerance between ethnicity and culture. The architectural concept in this mosque is a blend of Islam-China and its uniqueness is in the decoration of the mosque which has meaning and value.Keywords : Integration; Culture; Mosque.
The role of cardiac imaging before and after left atrial appendage standalone thoracoscopic exclusion
Authors: Mochen Marianna , Branzoli Stefano , D’Onghia Giovanni , Pertile Riccardo , Casagranda Giulia , Spagnolli Federica , Rozzanigo Umberto , Guarracini Fabrizio , Marini Massimiliano , Graffigna Angelo , Bonmassari Roberto , Menni Katiuscia , Mansueto Giancarlo , Cademartiri Filippo , Centonze Maurizio 
Published: February 2023

Aims
To assess the characteristics of left atrial appendage (LAA) stump and left atrial (LA) volume after standalone totally thoracoscopic LAA exclusion in 40 patients with nonvalvular atrial fibrillation (NVAF) and contraindications to oral anticoagulation (OAC), using cardiac computed tomography (CCT) and transoesophageal echocardiography (TOE).

Methods
Using CCT and TOE, we evaluated correct AtriClip Pro II positioning, the presence and characteristics of the LAA stump and the postprocedural LA volume, at 3 months’ follow-up. Stump depth was measured with both CCT and TOE using a new method, based on left circumflex artery (LCX) course.

Results
After placement of AtriClip, all 40 patients discontinued OAC, and no stroke occurred. LAA exclusion was achieved in 40/40 patients at 3 months’ follow-up. LAA stump (depth <10 mm in 12/18 stump, 67%) was observed in 18 patients. The overall (LA + LAA) volume and isolated LA volume were statistically different when comparing cases with and without LAA stump (P < 0.02). LAA ostium dimensions (perimeter and area) and LAA volume correlate with stump depth (P < 0.02). There was a high correlation between CCT and TOE in stump identification and depth measurement (P < 0.02). Compared with the baseline, CCT LA volume increased (P < 0.01) at 3 months’ follow-up.

Conclusion
Preprocedural and postprocedural CCT and TOE are useful and comparable in patients undergoing standalone totally thoracoscopic exclusion of LAA, because these imaging methods can identify anatomical LAA and LA characteristics predisposing for a postprocedural residual stump.
The Impact of Prenatal Diagnosis in the Evolution of Newborns with Congenital Heart Disease
Authors: Toma Daniela , Moldovan Elena , Gozar Liliana 
Published: February 2023

Abstract
Congenital heart malformations are cardiac and/or vascular structural abnormalities that appear before birth, the majority of which can be detected prenatally. The latest data from the literature were reviewed, with reference to the degree of prenatal diagnosis regarding congenital heart malformations, as well as its impact on the preoperative evolution and implicitly on mortality. Studies with a significant number of enrolled patients were included in the research. Prenatal congenital heart malformations detection rates were different, depending on the period in which the study took place, the level of the medical center, as well as on the size of enrolled groups. Prenatal diagnosis in critical malformations such as hypoplastic left heart syndrome, transposition of great arteries and totally aberrant pulmonary venous drainage has proven its usefulness, allowing an early surgical intervention, thus ensuring improved neurological development, increasing the survival rate and decreasing the rate of subsequent complications. Sharing the experience and results obtained by each individual therapeutic center will definitely lead to drawing clear conclusions regarding the clinical contribution of congenital heart malformations prenatal detection.
Using Data Mining in the Sentiment Analysis Process on the Financial Market
Authors: Cristescu Marian Pompiliu , Nerişanu Raluca Andreea , Mara Dumitru Alexandru 
Published: February 2023

Abstract
Sentiment analysis refers to the analysis of human opinions and sentiments that are expressed in written text, being also a part of the Natural Language Processing (NLP) tasks. Sentiment analysis can be applied in different domains, especially in the corporate marketing and sales, the healthcare system or the financial market analysis. In this paper we aim to highlight how data mining is able to extract the sentiment score from a financial platform that shows the major headlines regarding stocks, in order to highlight the publications’ positive or negative opinion over a stock. In order to gain the sentiment score we have scraped text data from the platform Finviz from which the polarity of the opinion may be extracted. We have also used Valence Aware Dictionary for Sentiment Reasoning (VADER), by running a Python script using the BeautifulSoup library. After that we have used Pandas (Python Data Analysis Library) to analyse and obtain a sentiment score on the article headlines. Results show that the script is able to generate the sentiment score for various selected stocks, while also showing graphical diagrams for the past and future trend of the stock, in terms of overall opinion on the stock performance.