bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microsurgical autologous ffbula transfer as an optimal method for closure of extensive bone defects in children with neuroffbromatosis
Authors: Golyana S. I. , Tikhonenko T. I. , Galkina N. S. , Grankin D. Yu. 
Published: September 2023

Introduction Pseudarthrosis and bone defects are the most common consequence of neurofibromatosis type I in children, a rare hereditary disease. Destruction of bone tissue leads to severe deformities and impaired function of the limbs. Disability in such patients may reach 70 %. Surgical treatment of children with this pathology is long, laborious and multi-stage. Traditional orthopaedic methods for managing bone defects are often ineffective. The development of microsurgical methods enables to perform bone transfer of blood-supplied bone autografts.Purpose To prove the effectiveness of using microsurgical autologous transfer of the vascularized fibula for plastic surgery of bone defects in children with neurofibromatosis type I.Materials and methods A retrospective monocenter study included 27 pediatric patients who underwent reconstruction of bone defects with a vascularized fibular autograft from 2011 to 2021. The etiology of the bone defect in all patients was neurofibromatosis type I. A fibula graft was used to reconstruct 8 tibiae and 19 forearms. Bone defects averaged 12 cm. Median follow-up was 60 months.Results The fibula graft survival rate was 100 %. In 5 cases, nonunion of the proximal part of the fibula and the recipient zone was obtained which required iliac crest grafting. The overall rate of good and excellent results was 74 %. The average time to consolidation was 3 months. Discussion According to the literature, the use of autografting of vascularized bone fragments is a ather limited procedure in children with neurofibromatosis type I as it is associated with an increased risk of complications. Due to the restoration of blood flow in the transferred vascularized autograft, it retains its viability and the possibility of bone tissue remodeling.Conclusion Microsurgical autologous transfer of a vascularised fragment of the fibula is an effective and at times indispensable method of bone plasty in long bone defects in children with type 1 neurofibromatosis. Bone defects larger than 5 cm are an indication for free autologous transfer of a vascularized fragment of the fibula. This method, used in combination with traditional orthopedic methods for the treatment of children, allows obtaining good anatomical and functional results.
Outcomes of various surgical techniques used in patients with closed traction injuries of the brachial plexus
Authors: Bazhanov S. P. , Shuvalov S. D. , Korshunova G. A. , Аjtemirov S. M. , Ostrovskij V. V. 
Published: September 2023

Introduction Traumatic lesions of the brachial plexus and analysis of the outcomes of various surgical techniques in patients with this pathology are the relevant challenges in neurosurgery, neurology, traumatology, orthopedics and rehabilitation due to the high social and economic significance, incidence and poor short- and long-term outcomes in this cohort of patients. This study was aimed at comparing the outcomes of various surgical techniques in patients with closed injuries of the brachial plexus.Material and methods The study involved 96 patients with closed injuries of the brachial plexus divided into three groups according to the method of their surgical treatment. Patients of Group I (n = 33) underwent microsurgical neurolysis of their brachial plexus trunks; patients of Group II (n = 28) had microsurgical neurolysis of their brachial plexus trunks with stimulating multichannel electrodes implanted on the trunks of their brachial plexus; patients of Group III (n = 35) had microsurgical neurolysis with stimulating multichannel electrodes implanted on the trunks of their brachial plexus as well as the segmental spinal cord apparatus at the level of the cervical intumescence. The clinical status and functionality of the upper limb were assessed after 6 months with clinical and neurological tests, scoring methods, and electrophysiological monitoring.Results We analyzed the outcomes of various surgical techniques in patients with closed injuries of the brachial plexus to prove a significant improvement in the outcomes of Group III patients who featured a faster rate of pain regression in the injured upper limb as well as significantly positive changes in clinical, neurological and electrophysiological indicators.Discussion The reduction in the total regional pain syndrome and restoration of the affected limb function was more evident in Group III patients what supports the favor of microsurgical neurolysis in combination with two-level electrical stimulation for closed injuries of the brachial plexus.Conclusions The analysis of various surgical techniques in patients with closed injuries of the brachial plexus revealed a significant efficacy of microsurgical neurolysis in combination with electrostimulation of the injured nerve trunk and segmental spinal cord apparatus (Group III). It improves the outcomes in this cohort of patients.
Fat embolism as a complication of lower extremity long-bone surgery
Authors: Grankin I. O. , Saifullin R. R. , Agafonova A. A. , Gudalina A. A. 
Published: September 2023

Introduction Fat embolism syndrome (FES) is a formidable complication that occurs with extremity long-bone fractures. Overall, the mortality of FES is estimated to be 10–36 % depending on the severity of the injury. Early detection of complications, selection of optimal methods for fracture fixation and for anesthesia that would prevent FES are essential.The objective was to assess the incidence of clinical manifestations of FES in patients with lower extremity long-bone fractures, determine the optimal methods of prevention, methods of anesthesia and surgical intervention in the management of the patients.Material and methods The study included 355 patients with lower extremity long-bone fractures treated between 2020 and 2021 at the Trauma Department, State Budgetary Healthcare Clinical N.I. Pirogov Hospital No. 1. Patients were grouped according to different parameters including frequency of occurrence of FES depending on the length of the preoperative period: patients with a long and short preoperative period; treatment strategy: patients treated surgically or conservatively; preoperative use of prophylaxis: patients receiving and not receiving "Essentiale"; anesthetic aidused: general or spinal anesthesia.Results Of the 355 patients examined, FES was detected in 8 patients with fractures of the lower extremities, one patient died. FES developed mainly in the first 72 hours of injury. FES occurred in less than 12 hours (n = 1), in 12-24 hours (n = 2), in 24-48 hours (n = 2), in 48-72 hours (n = 3).Discussion FES developed in patients with a delayed operative period and in patients treated conservatively. The prophylaxis policy suggests timely diagnosis using Schonfeld's scoring system for FES and taking "Essentiale" early post trauma. Patients who underwent surgery with spinal anesthesia showed a decreased incidence of FES as compared with patients operated on using general anesthesia.Conclusion There is a high incidence of FES. Hepatoprotectors can be used on the first days after injury to prevent FES. Osteosynthesis under spinal anesthesia is the preferred method of treatment.
Modeling the behavior of the acetabular axis and the axis of the ischial tuberosities during the transition from a standing to a sitting position
Authors: Peleganchuk A. V. , Turgunov E. N. , Mushkachev E. A. , Fedorova N. V. , Danilov M. N. , Korytkin A. A. , Pavlov V. V. 
Published: September 2023

Introduction The success of the treatment of patients with degenerative diseases of the spine and concomitant damage to the hip joint depends on the understanding of the biomechanics of movements in the spinal-pelvic segment. After a thorough analysis of the biomechanical processes occurring in the spine-pelvis system during the transition from a standing to a sitting position, it becomes clear that the acetabular axis of rotation of the pelvis in space is not the only one.The purpose of the study was to develop and test a virtual model of the pelvis to study the kinematics of the movement of the spinal-pelvic complex with a description of the emergence of the iscial axis of rotation by changing the position from standing to sitting.Materials and methods The problem was solved using the finite element method. The bones were modeled as absolutely rigid bodies. The main ligaments and muscles were modeled using finite element springs: elastic fragments with specified rheological characteristics. The study of contact interaction was carried out for pairs: "femoral head – acetabulum" and "ischial tuberosities - chair surface".Results A new axis of rotation was revealed, the ischial axis, which corresponded to the points of initial contact of the ischial tuberosities with the surface of the chair. The axis of the acetabulum rotated by 7.1° relative to the ischial axis and at the final moment shifted in the horizontal direction relative to the acetabular axis by 8.83 mm. The gap between the surfaces of the femoral head and the acetabulum was about 8 mm.Discussion The study shows that the pelvis rotates depending on the position around two axes: acetabular and ischial ones, hence it follows that the acetabular axis oscillates back and forth during ante- and retroversion, that is, it is non-static. Shortcomings of the model: 1) muscles and ligaments were modeled using FE springs, the end and beginning of which were set by two points, and the muscles and ligaments in the real body are attached along the entire surface of the bones; 2) soft tissues were not modeled in real volume. The merit of the study is the contact interaction of the pelvis with the chair and its rotation relative to the ischial axis, while other studies consider the rotation of the pelvis only relative to the acetabular axis.Conclusion A new axis of rotation arises due to the contact interaction of the pelvic bone with the surface of the chair when the skeleton moves from a standing position to a sitting position, the ischial axis. The gap between the surfaces of the femoral head and the acetabulum was about 8 mm. It is advisable to conduct a clinical study.
Comparative evaluation of the clinical efffcacy and safety of surgical approaches in total hip arthroplasty
Authors: Eremin I. K. , Daniliyants A. A. , Zagorodniy N. V. 
Published: September 2023

Background Advanced coxarthrosis is a leading cause of disability in patients. Total arthroplasty is regarded as the "gold standard" for the treatment of hip pathologies that are not amenable to conservative treatment. Arthroplasty introduced into clinical practice has significantly improved functional status of patients. The data are largely contradictory and indicate certain difficulties and risks at the stages of treatment and rehabilitation of patients after surgery. The shortcomings can be overcome by improving the treatment methods for the cohort of patients based on the results of large-scale comparative studies exploring the effectiveness of different approaches to all stages of treatment of arthroplastic patients.The objective was to search for the most justified and promising surgical approaches in terms of clinical efficacy and safety of total hip arthroplasty (THA).Material and methods The search for publications was produced using the databases of Scopus, PubMed and the electronic scientific library eLIBRARY in Russian and English languages using the keywords: total hip arthroplasty, minimally invasive approach, anterolateral approach in THA, direct lateral approach in THA, posterior approach in THA, comparative assessment of approaches in hip arthroplasty, advanced replacement techniques, incidence of postoperative complications in THA, direct anterior approach in THA.Results and discussion A number of studies have shown that interventions using direct anterior access (DAA) are characterized by less blood loss, less frequent blood transfusions, less operating time and shorter hospital stay. There was a more rapid recovery of the hip function during early postoperative period with less need for opioid analgesics with DAA. Complication rate was higher with DAA than in the comparison group, which directly correlated with the learning curve.Conclusion DAA was shown to be an advanced approach that resulted in enhanced clinical efficacy and safety of surgical treatment in the majority of patients with coxarthrosis with sufficient experience of the surgeon. The method can be considered as low-traumatic. Unlike other approaches, DAA was accompanied by less injury to intact tissues; smaller skin incision; less blood loss; precipitated postoperative rehabilitation; less severity of postoperative pain and less need for opioid analgesia. However, DAA is inferior to classical approaches in primarily complicated hip pathologies.
Analysis of Potential Educational Areas of Pokémon Go! Game Use Based on Mini FGI Method
Authors: Butkiewicz Magdalena , Kot Mateusz 
Published: September 2023

This article attempts to determine the educational nature of “Pokémon Go!” game based on user interactions with virtual space and real-life elements. For this purpose, interviews with players in mini focus groups (mini FGI) were the chosen method. Respondents were asked about their interaction with actual objects that are reflected in the game, how they search for information about the locations themselves, and about the educational content in the game space. The players were also asked for their ideas on how to enhance the educational potential of the game, as such opinion of real-life players was deemed notable.
Based on the results obtained, firstly, areas of potential educational value that still need to be improved were identified and, secondly, recommendations were formulated how to enhance the educational opportunities arising from the game.
Sanitation-hygiene Knowledge, Practices and Human Health Impacts: Insights from Coastal Bangladesh
Authors: Khan Md. Shohel , Paul Shitangsu Kumar 
Published: September 2023

Better sanitation and hygiene are very significant for sound health for human lives and it protects various water borne disease. This study aims to find sanitation-hygiene knowledge, practices and impacts on human health of coastal Bangladesh. Rajoir (Sarankhola), Gangarampur (Batiaghata) and Ganapatipur (Kalaroa) villages are purposively designated from shoreline, interim and inland coast. Data are collected with semi-structured questionnaire between July-October 2022 and analyzed through SPSS and map is produced with Arc GIS. Overall about 9.6, 36.3 and 54.1% respondents have good, moderate and poor knowledge regarding sanitation and hygiene. Overall about 57% respondents have accessed sanitary latrines. About 67% respondents claimed that their children deface are thrown in the toilet, followed by, around the house (16%). About 70, 83 and 84% respondents wash their hands with soap/handwash after defecation in shoreline, interim and inland area, followed by, 34, 35 and 27% before taking meal; 19, 19 and 4% before cooking; 9, 21 and 16% after household chores. Cleanliness index are categorized into satisfactory levels except water containers for shoreline (0.677) and inland (0.718) areas. About 96% (shoreline), 91% (interim) and 95% (inland) respondents claim women play a direct role during collection of water. Based on sanitation inspection tool, overall 6, 41, 47 and 3% tube-wells are grouped into very high, high, intermediate and low risk categories. About 57% (shoreline), 48% (interim) and 36% (inland) water sources are grouped into ‘high’s category. The study suggest to formate management committee to monitor proper sanitation and hygiene systems.
Keywords : Coastal area; human health; cleanliness; sanitary inspection tool

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
A muscadine locus confers resistance to predominant species of grapevine root-knot nematodes (<i>Meloidogyne</i> spp.) including virulent populations
Authors: Esmenjaud Daniel , Banora Mohamed Youssef , Julien-Portier Ulysse , Lafargue Maria-Das-Dores , Tandonnet Jean-Pascal , Rubio Bernadette , Walker Andrew , Van Ghelder Cyril , Ollat Nathalie 
Published: September 2023

Root-knot nematodes (RKNs) Meloidogyne spp. are extremely polyphagous pests and four species severely affect grapevines throughout the world: M. arenaria, M. incognita, M. javanica and M. ethiopica. Californian populations of M. arenaria and M. incognita are reported to be virulent to widely used rootstocks and to the rootstock ‘Harmony’ in particular. Breeding RKNs-resistant grape rootstocks is a promising alternative to highly toxic nematicides. Muscadine (Vitis rotundifolia syn. Muscadinia rotundifolia) is a resistance (R) source with undercharacterised genetics. To this end, we used a segregating progeny between the RKN-resistant Vitis x Muscadinia accession ‘VRH8771’ from the muscadine source ‘NC184-4’ and the RKN-susceptible V. vinifera cv. Cabernet-Sauvignon. We first phenotyped its resistance to isolates of the i) M. arenaria, ii) M. incognita and iii) M. javanica species, and then to iv) two mixed Harmony-virulent Californian populations of M. arenaria and M. incognita. Finally, we created an isolate of M. arenaria and M. incognita from these Harmony populations and phenotyped the progeny to each of them [v) and vi)], and to vii) an isolate of M. ethiopica. The resistance phenotype of all the progeny’s individuals was independent of the RKN isolates or populations used. Resistance was mapped in a region of chromosome 18 in VRH8771, supporting the hypothesis that it is conferred by a single gene with an unprecedented wide spectrum in grapevine, including Harmony-virulent isolates. This dominant gene, referred to as MsppR1, is linked to the telomeric QTL XiR4 for X. index resistance from the same source. Additionally, plant mortality data showed that MsppR1-resistant material expressed a high-level resistance to the Harmony-virulent isolates. Our results are a first step towards the development of marker-assisted breeding using SSR and SNP markers for resistance to RKNs in accession VRH8771.
Phyllanthus niruri (Meniran) Sebagai Imunomodulator: Mekanisme aksi dan senyawa bioaktif
Authors: Hikmah Uzulul , Triastuti Asih 
Published: September 2023

Latar belakang: Phyllanthus niruri merupakan tanaman obat yang memiliki beberapa aktivitas farmakologi seperti antimikroba, antioksidan, antikanker, antiinflamasi, antiplasmodium, antivirus, diuretik, hepatoprotektif, dan sebagai imunomodulator.
Tujuan: Melakukan tinjauan analisis mengenai efektivitas P. niruri) sebagai imunomodulator pada uji preklinis maupun uji klinis.
Hasil: Kandungan kimia P. niruri seperti flavonoid, lignan, terpenoid, dan alkaloid berperan penting pada aktivitas farmakologi P. niruri sebagai imunomodulator. Uji in silico menunjukkan potensi P. niruri sebagai imunomodulator pada infeksi Covid-19 dengan berikatan pada protein spike dan protease yang bertanggungjawab pada replikasi dan pematangan virus. Uji in vitro dan in vivo menunjukkan bahwa P. niruri mampu meningkatkan aktivitas fagositosis dari makrofag, meningkatkan antibodi serum total, dan mengurangi inflamasi. Pengujian klinis membuktikan bahwa P. niruri memiliki aktivitas imunomodulator baik pada subjek uji sehat maupun pada pasien.
Kesimpulan: Phyllanthus niruri memiliki aktivitas sebagai imunomodulator baik pada pengujian preklinis maupun klinis.
Kata kunci : Phyllanthus niruri, Imunomodulator, Imunostimulan, Metabolit sekunder
EFEKTIFITAS MODUL BERBASIS LITERASI LINGKUNGAN MELALUI PENDEKATAN SAINTIFIK
Authors: Syofyan Harlinda , Ratnawati Susanto  , Oktian Fajar Nugroho  , Vebryanti  , Dita Ramadhanti  , Ratih  , Indah Mentari  , Rani Mahareka  
Published: September 2023

Abstrak: Penelitian ini berlatar belakang tentang semakin menurunnya kesadaran kecintaan terhadap lingkungan dari generasi penerus bangsa ini. Perlu dilakukan internalisasi metode ataupun pendekatan dalam membangun kesadaran dalam menumbuhkan rasa bertangggung jawab kepada alam dan lingkungan. Lingkungan adalah tempat bernaung makhluk hidup sebagai tempat menjalani kehidupan. Pemenuhan kebutuhan akan hidup memberikan dampak buruk bagi lingkungan alam. Perhatian terhadap kelestarian lingkungan harus ditingkatkan dari berbagai aspek, salah satunya dalam bidang Pendidikan unttuk membimbing siswa dalam menumbuhkan generasi berliterasi lingkungan dengan menggunakan pendekatan saintifik. Siswa diajak mengamati, menanya, mengumpulkan informasi,menalar, dan kemudian mengkomunikasikan hasil yang telah disusun dari membaca, melihat fakta, serta berbagai informasi yang diperoleh dari berbagai cara dan sumber. Hal ini dapat dilatihkan melalui mahasiswa calon guru Pendidikan sekolah dasar untuk diterapkan dalam menunaikan tugas profesionalnya sebagai guru. Penelitian ini dilakukan untuk melihat keefektifan pemakaian modul berbasis literasi lingkungan melalui pendekatan saintifik dalam mata kuliah Konsep Dasar IPA Kelas Rendah. Subjek dari penelitian ini merupakan mahasiswa Pendidikan Guru Sekolah Dasar Universitas Esa Unggul Jakarta. Metode penelitian menggunakan penelitian pengembangan dengan menggunakan model Dick dan Carey. Keefektifan diukur berdasarkan hasil belajar yang didapatkan dari pretest dan postest. Hasil penelitian menunjukkan bahwa keefektifan penggunaan modul berbasis literasi lingkungan melalui pendekatan saintifik, dengan rata-rata kenaikan yakni 28%. Pendekatan Saintifik berbasis literasi lingkungan dapat digunakan dalam pembelajaran Konsep IPA Kelas Rendah.
Kata Kunci : modul, literasi lingkungan, pendekatan saintifik
PENGARUH METODE PICTURE AND PICTURE TERHADAP BERPIKIR KREATIF SISWA SEKOLAH DASAR
Authors: Laily Husniyah Mabruroh  , Apri Irianto  , Via Yustitia  
Published: September 2023

Berpikir kreatif merupakan kemampuan yang dapat digunakan mengembangkan potensi diri menghadapi tantangan abad-21. Siswa sekolah dasar harus mempunyai ide-ide kreatif dan inovatif terkait pengetahuan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh metode picture and picture terhadap kemampuan berpikir kreatif. Populasinya adalah siswa kelas V SD Hang Tuah 10 Juanda. Melalui teknik simple random sampling, terpilih siswa kelas V-A sebagai kelas kontrol dan kelas V-F sebagai kelas eksperimen. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian Quasi Experimental Design-Posttest Only Control Group. Metode pengumpulan data menggunakan tes. Data tes kemampuan berpikir kreatif dianalisis dengan uji beda rerata. Hasil penelitian menunjukkan bahwa terdapat pengaruh metode picture and picture terhadap kemampuan berpikir kreatif siswa.