bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies—Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforce
Authors: Asllani Julijana , Mitsias Dimitrios , Konstantinou George , Mesonjesi Eris , Xhixha Fatmira , Shehu Esmeralda , Christoff George , Noleva Katia , Makris Michael , Aggelidis Xenofon , Turkalj Mirjana , Damir Erceg , Agache Ioana , Tomic‐Spiric Vesna , Stosovic Rajica , Misirligil Zeynep , Kosnik Mitja , Popov Todor A. , Calderon Moises , Papadopoulos Nikolaos G. ,   ADER study group
Published: June 2023

AbstractBackgroundAlthough it has been shown that allergen immunotherapy (AIT) is well‐tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed.MethodsThe multinational Allergen Immunotherapy Adverse Events Registry (ADER) was designed to address AIT safety in real life clinical practice. Data on children ≤18 years old with respiratory allergies undergoing AIT were retrieved. Patient‐ and AIT‐related features were collected and analyzed. The characteristics of adverse events (AE) and risk factors were evaluated.ResultsA total of 851 patients, 11.3 ± 3.4 years old, with rhinitis only (47.6%); asthma and rhinitis (44.5%); asthma (7.9%), receiving 998 AIT courses were analyzed. Sublingual immunotherapy (SLIT) accounted for 51% of the courses. In 84.5% of patients only one AIT treatment was prescribed. Pollen was the most frequent sensitizer (57.1%), followed by mites (53.4%), molds (18.2%) and epithelia (16.7%). Local and systemic AEs were reported in 85 patients (9.9%). Most AEs (83.1%) were mild and occurred in <30 min (87%). Respiratory and cutaneous symptoms were more frequent. Only 4 patients (0.47%) had severe AE (none after 6 weeks of maintenance). The risk of AE was higher in patients undergoing SCIT.ConclusionsAIT is safe and well tolerated in children and adolescents with respiratory allergies in real‐life clinical practice. Though SCIT is more prone to AE compared to SLIT, overall severe reactions are rare and occur during build‐up and early maintenance.
Heterophile carbohydrate antigen N‐glycolylneuraminic acid as a potential biomarker in patients with hepatocellular carcinoma
Authors: Akimoto Shuji , Tahara Hiroyuki , Yanagawa Senichiro , Ide Kentaro , Tanaka Yuka , Kobayashi Tsuyoshi , Ohdan Hideki 
Published: June 2023

AbstractBackground and ObjectivesHepatocellular carcinoma (HCC) has a high recurrence rate even after radical hepatectomy. More optimal biomarkers may help improve recurrence and prognosis.MethodsWe investigated whether the oncological properties of N‐glycolylneuraminic acid (NeuGc) can participate in the prognosis of HCC. We evaluated the NeuGc antigen (Ag) expression in the HCC tissues and measured the preoperative anti‐NeuGc IgG antibodies (Abs) in the sera of the patients with HCC. We compared the clinical characteristics and survival rate in the hepatectomized patients (initial; n = 66, recurrent; n = 34) with and without the NeuGc Ag or Abs.ResultsMultivariate analyses showed positive expression of NeuGc Ag in HCC tissues (Odds ratio; initial = 6.3, recurrent = 14.0) and higher titers of preoperative anti‐NeuGc Ab (Odds ratio; initial = 4.9; recurrent = 3.8), which could be the predictive factors related to early recurrence. Both the NeuGc Ag‐positive and Ab‐positive groups in the initial hepatectomized patients exhibited significantly shorter recurrent free survival compared to those in the negative groups.ConclusionsOur findings suggested that anti‐NeuGc Ab titers and NeuGc Ag expression in the HCC tissues can be used as the predictive factors for the postoperative recurrence and prognosis of HCC.
Heterogeneous Catalytic Systems for Carbon Dioxide Hydrogenation to Value‐Added Chemicals
Authors: Mirzakhani Sara , Yin Ben Hang , Masteri‐Farahani Majid , Yip Alex C. K. 
Published: June 2023

AbstractUtilizing renewable energy to hydrogenate carbon dioxide into fuels eliminates massive CO2 emissions from the atmosphere and diminishes our need for using fossil fuels. This review presents the most recent developments for designing heterogeneous catalysts for the hydrogenation of CO2 to formate, methanol, and C2+ hydrocarbons. Thermodynamic challenges and mechanistic insights are discussed, providing a strong foundation to propose a suitable catalyst. The main body of this review focuses on nanostructured catalysts for constructing efficient heterogeneous systems. The most important factors affecting catalytic performance are highlighted, including active metals, supports and promoters that can potentially be used. The summary of the results and the outlook are presented in the final section. During the past few decades, heterogeneous CO2 hydrogenation has gained much attention and made tremendous progress. Thus, many highly efficient catalysts have been studied to discover their active sites and provide mechanistic insights. This paper summarizes recent advances in CO2 hydrogenation and its conversion into various hydrocarbons such as formate, methanol, and C2+ products. As for formate production, Au and Ru nanocatalysts show superior activity. However, considering the catalyst cost, Cu‐based catalysts have an excellent prospect for methanol production, among other catalysts. Ultra‐small nanoparticles and nanoclusters appear promising to provide highly active cost‐effective catalysts. A growing number of researchers are investigating the possibility of directly synthesizing C2+ products through CO2 hydrogenation. The major challenge in producing heavy hydrocarbons is breaking the ASF limitations, which have been achieved over bifunctional catalysts using zeolites. Using suitable support and promoter can lead to a superior activity, ascribed to structural, electronic, and chemical promotional effects.
HCFC1 variants in the proteolysis domain are associated with X‐linked idiopathic partial epilepsy: Exploring the underlying mechanism
Authors: He Na , Guan Bao‐Zhu , Wang Jie , Liu Han‐Kui , Mao Yong , Liu Zhi‐Gang , Yin Fei , Peng Jing , Xiao Bo , Tang Bei‐sha , Zhou Dong , Huang Guang , Dai Qi‐Lin , Zeng Ying , Han Hong , Zhai Qiong‐Xiang , Li Bin , Tang Bin , Li Wen‐Bin , Song Wang , Liu Liu , Shi Yi‐Wu , Li Bing‐Mei , Su Tao , Zhou Peng , Liu Xiao‐Rong , Guo Li‐Wu , Yi Yong‐Hong , Liao Wei‐Ping 
Published: June 2023

AbstractBackgroundHCFC1 encodes transcriptional co‐regulator HCF‐1, which undergoes an unusual proteolytic maturation at a centrally located proteolysis domain. HCFC1 variants were associated with X‐linked cobalamin metabolism disorders and mental retardation‐3. This study aimed to explore the role of HCFC1 variants in common epilepsy and the mechanism underlying phenotype heterogeneity.MethodsWhole‐exome sequencing was performed in a cohort of 313 patients with idiopathic partial (focal) epilepsy. Functional studies determined the effects of the variants on the proteolytic maturation of HCF‐1, cell proliferation and MMACHC expression. The role of HCFC1 variants in partial epilepsy was validated in another cohort from multiple centers.ResultsWe identified seven hemizygous HCFC1 variants in 11 cases and confirmed the finding in the validation cohort with additional 13 cases and six more hemizygous variants. All patients showed partial epilepsies with favorable outcome. None of them had cobalamin disorders. Functional studies demonstrated that the variants in the proteolysis domain impaired the maturation by disrupting the cleavage process with loss of inhibition of cell growth but did not affect MMACHC expression that was associated with cobalamin disorder. The degree of functional impairment was correlated with the severity of phenotype. Further analysis demonstrated that variants within the proteolysis domain were associated with common and mild partial epilepsy, whereas those in the kelch domain were associated with cobalamin disorder featured by severe and even fatal epileptic encephalopathy, and those in the basic and acidic domains were associated with mainly intellectual disability.ConclusionHCFC1 is potentially a candidate gene for common partial epilepsy with distinct underlying mechanism of proteolysis dysfunction. The HCF‐1 domains played distinct functional roles and were associated with different clinical phenotypes, suggesting a sub‐molecular effect. The distinct difference between cobalamin disorders and idiopathic partial epilepsy in phenotype and pathogenic mechanism, implied a clinical significance in early diagnosis and management.
Effect of phosphodiesterase‐5 inhibition on SystEmic Right VEntricular size and function. A multicentre, double‐blind, randomized, placebo‐controlled trial: SERVE
Authors: Greutmann Matthias , Tobler Daniel , Engel Reto , Heg Dik , Mueller Christian , Frenk André , Gabriel Harald , Rutz Tobias , Buechel Ronny R. , Willhelm Matthias , Trachsel Lukas , Freese Michael , Ruperti‐Repilado Francisco Javier , Valsangiacomo Buechel Emanuela , Beitzke Dietrich , Haaf Philip , Wustmann Kerstin , Schwitz Fabienne , Possner Mathias , Schwitter Juerg , Bouchardy Judith , Schwerzmann Markus ,   SERVE Investigators
Published: June 2023

AimsIn adults with congenital heart disease and systemic right ventricles, progressive right ventricular systolic dysfunction is common and is associated with adverse outcomes. Our aim was to assess the impact of the phosphodiesterase‐5‐inhibitor tadalafil on right ventricular systolic function.Methods and resultsThis was a double‐blind, randomized, placebo‐controlled, multicentre superiority trial (NCT03049540) involving 100 adults with systemic right ventricles (33 women, mean age: 40.7 ± 10.7 years), comparing tadalafil 20 mg once daily versus placebo (1:1 ratio). The primary endpoint was the change in right ventricular end‐systolic volume after 3 years of therapy. Secondary endpoints were changes in right ventricular ejection fraction, exercise capacity and N‐terminal pro‐B‐type natriuretic peptide concentration. Primary endpoint assessment by intention to treat analysis at 3 years of follow‐up was possible in 83 patients (42 patients in the tadalafil group and 41 patients in the placebo group). No significant changes over time in right ventricular end‐systolic volumes were observed in the tadalafil and the placebo group, and no significant differences between treatment groups (3.4 ml, 95% confidence interval −4.3 to 11.0, p = 0.39). No significant changes over time were observed for the pre‐specified secondary endpoints for the entire study population, without differences between the tadalafil and the placebo group.ConclusionsIn this trial in adults with systemic right ventricles, right ventricular systolic function, exercise capacity and neuro‐hormonal activation remained stable over a 3‐year follow‐up period. No significant treatment effect of tadalafil was observed. Further research is needed to find effective treatment for improvement of ventricular function in adults with systemic right ventricles.
A New Class of Two‐Deck Dicationic Heteropentalenes Existing by the Balance between Interdeck Aromaticity and Covalent P−P Bonding
Authors: Sushev Vyacheslav , Panova Yulia , Khristolyubova Alexandra , Zolotareva Natalia , Grishin Matvey , Rumyantcev Roman , Kozlova Ekaterina , Fukin Georgy , Kornev Alexander 
Published: June 2023

AbstractA number of two‐deck dicationic 3a,6a‐diaza‐1,4‐diphosphapentalenes (DDP)2X2 (X=halogen or complex ion) have been characterized. Interdeck distances P(1)⋅⋅⋅P(3) and P(2)⋅⋅⋅P(4) in crystal structures, as a rule, significantly exceed the sum of covalent radii, however they are still within the sum of van der Waals radii. The 31P NMR data indicate that phosphorus atoms are equivalent in solution even at low temperatures (233 K). Based on DFT calculations, the formation of two equivalent P−P covalent bonds (<2.4 Å) is energetically unfavorable, despite the absence of steric barriers. The total energy of the model dication as a function of the P⋅⋅⋅P separation has a minimum at the P−P distance of 2.85 Å. This distance corresponds to the highest aromaticity index in the interdeck space (NICS(1.0)=−20.72). The energy of interdeck interactions is estimated at 10–15 kcal/mol.
Suspended sediment deposition and sediment yields at Lake Peters, northeast Brooks Range, Alaska: Fluvial‐ and lake‐based approaches
Authors: Thurston Lorna Louise , Schiefer Erik , McKay Nicholas P. , Kaufman Darrell S. 
Published: June 2023

AbstractLake‐based studies can provide seasonal‐ to millennial‐scale records of sediment yield to improve our understanding of catchment‐scale sediment transfer and complement shorter fluvial‐based sediment transport studies. In this study, sediment accumulation rates at 40 coring locations in Lake Peters, Brooks Range, Alaska, over ca. 42 years, calculated using fallout radionuclides and sediment density patterns, were spatially modelled based on distance from the primary inflow and lake water depth. We estimated mean interdecadal specific sediment yield (Mg km−2 year−1) using the spatially modelled sediment accumulation rates and compared that result to fluvial‐based sediment delivery for 2015–2016 open‐channel seasons, as well as to yields reported for other Arctic catchments. Using the lake‐based method, mean yield to Lake Peters between ca. 1973 and 2015 was 52 ± 12 Mg km−2 year−1, which is comparable with fluvial‐based modelling results of 33 (20–60) Mg km−2 year−1 in 2015 and 79 (50–140) Mg km−2 year−1 in 2016 (95% confidence intervals), respectively. Although 2016 was a year of above average sedimentation, the last extreme depositional event probably occurred between ca. 1970 and 1976 when a basal layer of fine sand was deposited in a broadly distributed, relatively thick and coarse bed, which we used for lake‐wide correlation. The dual lacustrine–fluvial method approach permits study of within‐lake and catchment‐scale processes. Within Lake Peters, sedimentation patterns show decreasing fluxes down‐lake, sediment bypassing near the primary inflow, the influence of secondary inflows and littoral redistribution, and a focusing effect in the deep proximal basin. At the watershed scale, sediment yield is largely driven by intense summer rainfall and strong seasonal hydroclimatic variability. This research informs paleo‐environmental reconstruction and environmental system modelling in Arctic lake catchments.
Harmonizing the rural Indigenous family: Mestiza gender trustees and the gendered modernization of rural Mexico
Authors: Pacheco Raquel 
Published: June 2023

AbstractThe 2018 film Roma popularized the idea that domestic work is a site through which female employers and employees can support one another as they confront the relegation of reproductive labor to women. Echoes of this narrative can be heard in the workshops provided to Nahua men and women of the Huasteca region of Mexico by what I call gender trustees who are bent on modernizing rural men and women. This modernization is imagined as gender progress—one in which men and women come to redistribute housework and to adopt a dual earning marital model in which women work outside the home rather than as peasant women or housewives. These feminist notions of the good, therefore, demonstrate an affinity with neoliberal narratives of modernization that seek to move the Mexican rural population away from small‐scale farming and into the service and maquila sectors of the economy. The ungendering experiences of Indigenous women domestic workers suggest that both the sororal narrative epitomized by the dominant interpretation of Roma as well as the idea that paid work makes women equal vis‐à‐vis their husbands continue to sanitize and euphemize the highly gendered and racialized and settler colonial labor niche which is domestic work.
Effect of blue light on the cell viability of A549 lung cancer cells and investigations into its possible mechanism
Authors: Jiang Hui , Qin Haokuan , Sun Miao , Lin Shangfei , Yang Jiali , Liu Muqing 
Published: June 2023

AbstractBlue light has attracted extensive attention as a new potential cancer therapy. Recent studies have indicated that blue light has a significant inhibition effect on A459 cells. However, the effect of light parameters on the treatment of A549 cells and the mechanism of how blue light made the effect was still unclear. This study aimed to investigate A549 cells responses to blue light with varying irradiance and dose‐dense, and tried to find out the mechanism of the effects blue light made. The results suggested that the responses of A549 cells to blue light with different irradiance and dose‐dense were different and the decrease of cell viability reached saturation when the irradiance reached 3 mW/cm2 and the dose‐dense reached 3.6 J/cm2. It was assumed that blue light suppressed PI3K/AKT pathway and promoted the expression of JNK and p53 to affect the proliferation of A549 cells.
Data for characterization of the optical properties of Atlantic salmon (Salmo salar) blood
Authors: Svendsen Eirik , Randeberg Lise L. , Føre Martin , Finstad Bengt , Olsen Rolf Erik , Bloecher Nina , Alfredsen Jo Arve 
Published: June 2023

AbstractPhotoplethysmography is a recent addition to physio‐logging in Atlantic salmon which can be used for pulse oximetry provided that the properties for light propagation in salmon tissues are known. In this work, optical properties of three constituents of Atlantic salmon blood have been characterized using a photo spectrometer in the VIS–NIR range (450–920 nm). Furthermore, Atlantic salmon blood cell size has been measured using a Coulter counter as part of light scattering property evaluations. Results indicate that plasma contributes little to scattering and absorption for wavelengths typically used in pulse oximetry as opposed to blood cells which are highly scattering. Extinction spectra for oxygenated and deoxygenated hemoglobin indicate that Atlantic salmon hemoglobin is similar to that in humans. Pulse oximetry sensors originally intended for human applications may thus be used to estimate blood oxygenation levels for this species.
A supposedly objective thing I'll never use again: Word association and the quest for validity and reliability in emotional adjustment research from Carl Jung to Carl Rogers (1898–1927)
Authors: Fierro Catriel 
Published: June 2023

AbstractAs the first two decades of the 20th century unfolded, clinical psychologists, who had until then been mainly associated with intelligence testing, attempted to implement a specific psychological method—Carl Gustav Jung's (1875–1961) word‐association “test”—in individual personality assessments. As one of the early clinical psychologists who attempted to use the method, Carl Ransom Rogers (1902–1987) is conspicuously absent from the historiography of clinical psychological testing. In fact, historians have recently suggested that we are lacking narratives about Rogers' early ideas and techniques in the context of both the development of clinical psychology and the emergence of psychological testing as clinicians' foremost scholarly activity. In light of the above, this paper pursues two main goals. First, it attempts to reconstruct Rogers' first original research project on emotional adjustment testing in young children in the broader context of the development of word‐association tests as carried out by Jung and Whately Smith (1892–1947). Second, it aims to reconstruct Rogers' earliest theoretical ideas as well as his epistemological assumptions regarding test objectivity, validity and reliability. By drawing on unpublished documents and heretofore overlooked primary sources I show that although Rogers initially drew from Jung and Smith's complex and refined tradition, he ultimately rejected it as well as the tests themselves. At first drawn to Smith's quantitative, empiricist and experimental philosophy of psychology, Rogers was deterred when the data gathered through his own research in 1927 suggested that word association tests had no real, effective clinical value when used in children. By showcasing the complex process of test construction and validation undertaken by 1920s clinical psychologists, Rogers' case illustrates the research practices, the methodological problems and the epistemological dilemmas faced by most if not all of his contemporaries.
Sleep apnea severity in patients undergoing atrial fibrillation ablation: Home sleep apnea‐test and polysomnography comparison
Authors: Tanaka Nobuaki , Okada Masato , Tanaka Koji , Onishi Toshinari , Hirao Yuko , Harada Shinichi , Kawahira Masatsugu , Koyama Yasushi , Fujii Kenshi , Watanabe Heitaro , Okamura Atsunori , Sakata Yasushi , Iwakura Katsuomi 
Published: June 2023

AbstractBackgroundSleep apnea (SA) is highly prevalent and should be treated in patients referred for catheter ablation (CA) of atrial fibrillation (AF). Watch‐type peripheral arterial tonometry (WP) for home SA testing has demonstrated a high correlation of the apnea‐hypopnea index (AHI) with Polysomnography (PSG), but the evidence of its accuracy in AF patients is not adequate.MethodsThis study was conducted under a retrospective, single‐center, observational design. We included 464 consecutive AF patients (age 65 ± 11 years, 76.5% male, 45.0% paroxysmal‐AF) who received both WP and PSG during the periprocedural period of the CA. We compared the AHI using the WP (WP‐AHI) to that using PSG (PSG‐AHI).ResultsThe WP‐AHI was 25.9 ± 12.7 and PSG‐AHI 31.4 ± 18.9 (r = .48). Among 325 patients with a WP‐AHI < 30, 116 (35.7%) exhibited a PSG‐AHI ≥ 30. Only 12.5% of the patients were indicated for continuous positive airway pressure (CPAP) treatment only by the WP‐AHI, while 70.9% were indicated for CPAP by the PSG‐AHI according to the Japanese health insurance system. The best cut‐off value of the WP‐AHI was 18.1 to predict a PSG‐AHI ≥ 20 with an area under the curve of 0.72 (95% confidence interval, 0.67–0.76).ConclusionsThe WP‐AHI and PSG‐AHI were weakly correlated in AF patients receiving CA. About one‐third of the patients with moderate SA using the WP was diagnosed with severe SA evaluated by PSG. The majority required PSG for the CPAP indication.
LncRNA CDKN2B‐AS1 interacts with LIN28B to exacerbate sepsis‐induced acute lung injury by inducing HIF‐1α/NLRP3‐mediated pyroptosis
Authors: Miao Run‐Feng , Tu Jing 
Published: June 2023

AbstractSepsis‐associated acute lung injury (ALI) is a life‐threatening condition in intensive care units with high mortality. LncRNAs have been confirmed to participate in the underlying pathogenesis of septic ALI. This study investigated the biological functions of lncRNA CDKN2B‐AS1 in septic ALI and its potential mechanism.BEAS‐2B cells were challenged with lipopolysaccharide (LPS) and mice were subjected to caecal ligation and puncture (CLP) to induce septic ALI in vitro and in vivo. The expression levels of CDKN2B‐AS1, LIN28B, HIF‐1α, and pyroptosis‐related molecules were assessed by qRT–PCR or Western blotting. The production of IL‐1β and IL‐18 was detected by ELISA. BEAS‐2B cell pyroptosis was examined by flow cytometry. The interaction between LIN28B and CDKN2B‐AS1/HIF‐1α was validated by RIP and RNA pull‐down assays. Colocalization of CDKN2B‐AS1 and LIN28B was observed by FISH. ALI was determined by HE staining, the lung wet‐to‐dry (W/D) weight ratio, inflammatory cell numbers, and total protein concentration in bronchoalveolar lavage fluid (BALF). Caspase‐1 expression in the lung tissues was examined by immunohistochemical staining.CDKN2B‐AS1 was upregulated in BEAS‐2B cells after LPS stimulation. CDKN2B‐AS1 knockdown inhibited pyroptosis in LPS‐exposed BEAS‐2B cells in vitro and the lung tissues of septic mice in vivo. Mechanistically, CDKN2B‐AS1 interacted with LIN28B to enhance HIF‐1α stability. Rescue experiments showed that HIF‐1α overexpression counteracted the inhibitory effect of sh‐CDKN2B‐AS1 on LPS‐induced pyroptosis. CDKN2B‐AS1 bound to LIN28B to trigger NLRP3‐mediated pyroptosis by stabilizing HIF‐1α, which promoted sepsis‐induced ALI. CDKN2B‐AS1 might be a novel therapeutic target for this disease.