bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between physical activity and subjective well-being in Chinese university students: the mediating roles of perceived health, social support and self-esteem
Authors: Liao Tianzhi , Yin Yujia , Hu Xiaoyong , Shim Yunsik , Tang Saizhao 
Published: July 2023

Abstract
Purpose
The intent of this paper is to understand the effect of physical activity on university students' subjective well-being and to explore whether perceived health, social support, and self-esteem play roles as mediating variables.
Methods
Self-reported data from 404 college students (147 males and 257 females) were analyzed using structural equation modeling (SEM). The relationships between the study variables were tested by mediation models and 5000 bootstrap samples using AMOS version 24.
Results
(1) All of the first six hypotheses were supported in the measurement model in the results. Physical activity was significantly related to social support, to perceived health, and to self-esteem; social support, perceived health and self-esteem were all significantly related to subjective well-being. However, the direct positive effect of physical activity gradually decreased in the order of self-esteem, social support, and perceived health. The direct effect of perceived health, social support, and self-esteem on subjective well-being also decreased sequentially. (2) In the measurement model, all three hypotheses of mediation were supported, showing positive indirect effects between physical activity and subjective well-being. Of the three mediating effects, social support and self-esteem were not significantly different, and the mediating effect of perceived health showed the largest impact. This indicates that social support, perceived health, and self-esteem mediate the effects of physical activity, and subjective well-being regulation has positive indirect effects.
Conclusion
This study demonstrates the importance of meeting the needs of social support, perceived health, and self-esteem when designing interventions to promote college students' sports participation to enhance subjective well-being.
Clinical characteristics and outcomes of unvaccinated kidney transplant patients infected with SARS-CoV-2 omicron subvariant BA.5.2
Authors: Qu Yue , Zhuang Jing , Duan Yanya , Baibutihan Ahebaota , Maimaiti Zuolamu , Zhang Changrong , Niu Junqiao , Teng Wei , Ailimu Maierdang , Wei Xuemei , Qi Baowen , Li Jiuzhi , DU Shuang , Wang Dingding , Cao Ke , Wang Junyan , Lu Chen , Tian Xuefei , Jiang Hong 
Published: July 2023

Abstract
Background
Kidney transplant (KT) recipients, who are chronically immunocompromised, face increased risks due to COVID-19 and lower vaccination rates. Limited knowledge exists regarding the clinical characteristics of unvaccinated KT patients with COVID-19. This study aimed to examine the clinical features and outcomes of unvaccinated KT patients infected with SARS-CoV-2 omicron subvariant BA.5.2.
Methods
The study enrolled 36 unvaccinated KT patients with COVID-19 and compared them to 20 infected control cases without underlying medical conditions. Clinical characteristics, laboratory tests, treatment regimens, and outcomes were analyzed. RT-PCR confirmed SARS-CoV-2 Omicron BA.5.2 subvariant infection.
Results
The KT patients experienced severe disease, with 66.7% classified as severe/critical illness. Dyspnea on admission, lower blood leukocyte and lymphocyte counts, hemoglobin levels, and serum albumin levels were more prevalent in the KT group compared to the control group. Severe/critical illness was associated with factors such as age, diabetes mellitus, lung infection CT score, and elevated levels of D-dimer, IL-6, CRP, Procalcitonin, and ferritin. Blood lymphocyte counts and serum albumin levels were significantly lower in the severe/critical illness group in KT patients. Treatment included discontinuation of anti-metabolic drugs, reduction, or discontinuation of calcineurin inhibitor drugs, antiviral therapy, and early patient-tailored nutritional support. Acute kidney injury was observed in 19.4% of cases, and four patients died during the observation period.
Conclusions
Early diagnosis, personalized treatment regimens, and diligent monitoring are crucial for unvaccinated KT patients with COVID-19. These findings contribute to understanding the clinical characteristics and management of COVID-19 in the KT population.
Generative design of conformal cooling channels for hybrid-manufactured injection moulding tools
Authors: Wilson Neil , Gupta Manhar , Patel Milan , Mazur Maciej , Nguyen Vu , Gulizia Stefan , Cole Ivan 
Published: July 2023

Abstract

Effective cooling systems for injection moulding (IM) tools are critical to reducing manufacturing costs & cycle time for the polymer parts that they produce. This work presents a novel automated methodology for designing conformal cooling channels (CCCs) for injection moulding (IM) tools. This is done through existing commercial moulding simulation tools interlinked with custom scripts that adjust CCC design in response to the spatial variability in global andlocal temperature at the mould tool-part interface (MTPI). Four mould tool designs for a hollow cylinder were developed and analysed via both numerical simulation and experiments. These include (i) conventional IM tool with straight-drilled cooling channels made of tool steel, (ii) a manually designed CCC system with stainless steel, (iii) copper-aluminium bronze ‘core’ andstainless steel ‘shell’ with CCCs identical to (ii), and (iv) stainless steel with a CCC system automatically designed using generative design (GD) driven by a genetic algorithm. Tool (ii) cooled the part faster than conventional tool with a manually designed CCC system (i) (3-5% predicted vs. 40% measured), as did tool (iii) with the bronze core (9-12% predicted vs. 40% measured). The GD-optimised CCC tool (iv) cooled fastest in both the predicted results (15-30%, 11-25% & 1.5-25% faster than (i), (ii) & (iii)) andmeasured results (70%, 50% & 50% for (i), (ii) & (iii)). The predicted MTPI temperatures were also lower for the GD-optimised tool (65%, 75% & 34% below (i), (ii) & (iii)). Therefore, the novel methodology proposed here for automatically designing IM tool CCCs achieves reduced (a) maximum andspatial variability in MTPI temperatures, (b) cooling time, and (c) warpage.
WITHDRAWN: Augmented Reality as a Support in the Process of Spatial Development
Authors: Kaźmierczak Rafał , Szczepańska Agnieszka 
Published: July 2023

Abstract
Design solutions for methods of future spatial development, contained in planning documents, are presented as 2D graphics with supplementary descriptions. Lack of specialist knowledge and in-sufficient spatial imagination in various readers of such documents results in problems with ab-sorbing the document contents, both in their graphical and textual parts. In consequence, objects can be constructed that disrupt the spatial order, although with no legal violation. This problem can be solved by applying augmented reality (AR) in spatial planning. This paper presents the capabilities of a method for visualizing different variants of spatial development, with buildings as examples. A building plot with its surrounding area, covered by a local spatial development plan, was used as a model. By modelling future land development with AR technology, it was possible to demonstrate a lack of precision of the plan and its potential impact on the method of spatial development, with resulting deterioration of the spatial order. The utility of 3D visualization of a plan to an average reader was also presented, which can be used at the stage of preparing planning documents (community participation, adopting the plan) and at the stage of passing by-laws (councilors) and when it is in force (investors’ decisions).
Efficacy of second-line chemotherapy after treatment with gemcitabine plus nab-paclitaxel or FOLFIRINOX in patients with metastatic pancreatic cancer: results from the NAPOLEON study
Authors: Fukahori Masaru , Okabe Yoshinobu , Shimokawa Mototsugu , Otsuka Taiga , Koga Futa , Ueda Yujiro , Nakazawa Junichi , Komori Azusa , Otsu Satoshi , Arima Shiho , Makiyama Akitaka , Taguchi Hiroki , Honda Takuya , Ushijima Tomoyuki , Miwa Keisuke , Shibuki Taro , Nio Kenta , Ide Yasushi , Ureshino Norio , Mizuta Toshihiko , Mitsugi Kenji , Shirakawa Tsuyoshi 
Published: July 2023

Abstract
First-line chemotherapy for patients with metastatic pancreatic cancer (MPC) includes gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX). However, the efficacy of second-line chemotherapy and the role of combination chemotherapy in clinical practice is still unknown. Data was gathered from 14 hospitals in the Kyushu area of Japan from December 2013 to March 2017. The median overall survival (mOS) from second-line treatment was contrasted between patients who received second-line chemotherapy (CT group) and those who received the best supportive care (BSC group). Furthermore, the mOS of combination chemotherapy was compared to mono chemotherapy in the CT group. To control possible bias in the selection of treatment, we performed a propensity score-adjusted analysis. A total of 255 patients received GnP or FFX as first-line chemotherapy. There were 156 in the CT group and 77 in the BSC group of these. The CT group had a significantly longer mOS than the BSC group (5.2 vs. 2.6 months; adjusted hazard ratio (HR) 0.38; 95% CI: 0.27–0.54). In the CT group, 89 patients received combination chemotherapy while 67 received mono chemotherapy. The mOS did not differ significantly between the combination and mono chemotherapy groups (5.5 vs. 4.8 months; adjusted HR 0.88; 95% CI: 0.58–1.33). Among patients with MPC receiving second-line treatment, the CT group had a significantly longer mOS than the BSC group, but combination chemotherapy conferred no improvement in survival compared to mono chemotherapy.
Myristoylated, Alanine-rich C-kinase Substrate (MARCKS) regulates Toll-like receptor 4 signaling in macrophages
Authors: Issara-Amphorn Jiraphorn , Sjoelund Virginie , Smelkinson Margery , Yoon Sung Hwan , Manes Nathan P. , Nita-Lazar Aleksandra 
Published: July 2023

Abstract
MARCKS (Myristoylated Alanine-rich C-kinase Substrate) is a membrane protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation. LPS (lipopolysaccharide) triggers inflammation via TLR4 (Toll-like receptor 4). The presence of MARCKS and the formation of phospho-MARCKS in macrophages have been described, but the role(s) of MARCKS in regulating macrophage functions remain unclear. To investigate the role of MARCKS during inflammation, we activated macrophages using LPS with or without the addition of a PKC inhibitor. We found that PKC inhibition substantially decreased macrophage IL6 and TNF cytokine production. In addition, confocal microscopy revealed that MARCKS and phospho-MARCKS increased localization to endosomes and the Golgi apparatus upon LPS stimulation. CRISPR-CAS9 mediated knockout of MARCKS in macrophages downregulated TNF and IL6 production, suggesting a role for MARCKS in inflammatory responses. Our comprehensive proteomics analysis together with real-time metabolic assays comparing LPS-stimulation of WT and MARCKS knock-out macrophages provided insights into the involvement of MARCKS in specific biological processes and signaling pathways, uncovering specific proteins involved in regulating MARCKS activity upon LPS stimulation. MARCKS appears to be a key regulator of inflammation whose inhibition might be beneficial for therapeutic intervention in inflammatory related diseases.
Effectiveness of a telehealth-delivered clinician-supported exercise and weight loss program for hip osteoarthritis – protocol for the Better Hip randomised controlled trial
Authors: Bennell Kim L , Keating Catherine , Lawford Belinda , Graham Bridget , Hall Michelle , Simpson Julie A , McManus Fiona , Hosking Brinley , Sumithran Priya , Harris Anthony , Woode Maame Esi , Francis Jill J , Marlow Jennifer , Poh Sharon , Hinman Rana S 
Published: July 2023

Abstract
Background:
Hip osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Self-management is vital with education, exercise and weight loss core recommended treatments. However, evidence-practice gaps exist, and service models that increase patient accessibility to clinicians who can support lifestyle management are needed. The primary aim of this study is to determine the effectiveness of a telehealth-delivered clinician-supported exercise and weight loss program (Better Hip) on the primary outcomes of hip pain on walking and physical function at 6 months, compared with an information-only control for people with hip OA.
Methods:
A two-arm, parallel-design, superiority pragmatic randomised controlled trial. 212 members from a private health insurance fund aged 45 years and over, with painful hip OA will be recruited. Participants will be randomly allocated to receive either: i) Better Hip; or ii) web-based information only (control). Participants randomised to the Better Hip program will have six videoconferencing physiotherapist consultations for education about OA, prescription of individualised home-based strengthening and physical activity programs, behaviour change support, and facilitation of other self-management strategies. Those with a body mass index >27kg/m2, aged <80 years and no specific health conditions, will also be offered six videoconferencing dietitian consultations to undertake a weight loss program. Participants in the control group will be provided with information about managing hip OA via a custom website. All participants will be reassessed at 6 and 12 months. Primary outcomes are hip pain on walking and physical function. Secondary outcomes include measures of pain; hip function; weight; health-related quality of life; physical activity levels; global change in hip problem; willingness to undergo hip replacement surgery; rates of hip replacement; and use of oral pain medications. A health economic evaluation at 12 months will be conducted and reported separately.
Discussion:
Findings will determine whether a telehealth-delivered clinician-supported lifestyle management program including education, exercise/physical activity and, for those with overweight or obesity, weight loss, is more effective than information only in people with hip OA. Results will inform the implementation of such programs to increase access to core recommended treatments.
Trial registration:
Australia New Zealand Clinical Trials Registry (ACTRN12622000461796)
Differential silica nanoparticles functionalized with branched poly(1-Vinyl-1,2,4-triazole): antibacterial, antifungal, and cytotoxic qualities
Authors: Usul Sedef Kaptan , Lüleci Hatice Büşra , Değirmenci Nurdan Sena , Ergüden Bengü , Aslan Ayşe 
Published: July 2023

Abstract
This research aims to improve antimicrobial materials based on functional silica nanoparticles. Three different methods were used in the study to create silica nanoparticles with other properties. The nanoparticles' morphological structures are porous, hollow, and filled with spherical forms. The surface of these nanoparticles was grafted with poly(1-vinyl-1,2,4-triazole) (PVTri). The morphological properties of nanocomposites were used for analyze. In contrast, thermal gravimetric analysis was used to characterize the thermal properties of nanocomposites (TGA). The silica nanoparticles were evaluated for them in vitro antimicrobial activity against, Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae using minimum inhibitory concentration (MIC) measurement. Silica nanoparticles have different antifungal and antibacterial properties related to their structure. The cytotoxic effects of the silica nanoparticles on HaCaT cells were performed with an MTS assay. In this study, we observed that high doses of HSS and e-SiO2 decreased cell growth, while HSS and e-SiO2 composite with PVTri increased cell proliferation.
Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer
Authors: Hayama Tamuro , Hama Kotaro , Ozawa Tsuyoshi , Fujiwara Yuko , Nozawa Keijiro , Matsuda Keiji , Yokoyama Kazuaki , Hashiguchi Yojiro , Ochiai Hiroki , Misawa Takeyuki , Fukagawa Takeo 
Published: July 2023

Abstract
Background
Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells. In particular, the authors have reported differences in sphingolipid content in colorectal cancer tissues. The associations among genetic mutations, clinicopathological factors, and sphingolipid metabolism in colorectal cancer (CRC) have not been investigated.
Purpose
The aim of this study was to clarify the relationships among mutations of genes associated with sphingolipid metabolism and clinicopathological factors in CRC.
Patients and Methods
We performed a cohort study of the medical records of 82 consecutive patients with stage I-IV CRC who underwent tumor resection at a single institution in 2019–2021. We quantified the expression levels of genes involved in sphingolipid metabolism and analyzed the correlation between these gene expression profiles and the clinical data of each patient.
Results:
When relationships between patients’ KRAS mutation status and levels of ceramide synthase (CERS), N-acylsphingosine amidohydrolase (ASAH) and alkaline ceramidase (ACER) genes, all involved in sphingolipid metabolism, the CRES4 expression level was significantly lower in the KRAS mutant group (p = 0.004). In terms of clinicopathological measures, the rate of venous invasion was significantly higher in the low-CERS4-expression group (p = 0.0057).
Conclusions
By examining the correlation between sphingolipid gene expression and clinical factors, we were able to identify cancer types in which sphingolipid metabolism is particularly relevant. CERS4 expression was significantly reduced in KRAS mutant CRC. Moreover, CRC with decreased CERS4 showed significantly more frequent venous invasion.
The Effect of High-Pressure Cutting Fluid Supply on the Chip Breakability of Lead-Free Brass Alloys
Authors: Müller Magdalena Susanne , Brans Kilian , Meurer Markus , Sørby Knut , Bergs Thomas 
Published: July 2023

Abstract
To improve machinability and in particular chip breakability, brass alloys are usually alloyed with small quantities of lead. Due to environmental and health concerns, the use of lead has been restricted in the last years. As lead-free brass alloys are progressively implemented in the industry, challenges arise due to their differing properties from traditional leaded brass alloys. One of the main challenges in automated continuous cutting processes is the worse chip breakability of lead-free brass alloys leading to longer and tangled chips. Hence, the impact of a high-pressure cutting fluid supply, as well as the impact of a chip-breaking geometry and the combined effect of both, has been investigated at different feeds. The three brass alloys CuZn37 (CW508L), CuZn38As (CW511L), and CuZn42 (CW510L) were studied at varying cutting fluid supply pressure levels and feed rates in a radial cutting operation. Cutting forces were measured, and chips were analyzed. No overall systematic impact of the cutting fluid supply pressure on the cutting forces was observed. In conclusion, increased pressure levels, a chip-breaking geometry, and an increased feed rate enhance the chip breakability of the investigated alloys.
Assessment of ambient air quality in the industrial areas of Ahmedabad, Gujarat (India)
Authors: Thakur Bignesh , Sharma Chandramauly , Agrawal Yadvendra 
Published: July 2023

Abstract
Air pollution stands as the paramount global environmental menace, casting its shadow over public health and claiming a staggering estimate of 7 million lives prematurely each year. The intertwining relationship between air pollution and climate change cannot be ignored, as their shared sources and impact on the climate reveal a profound connection. The battle for improved air quality holds the key to unlocking not only health benefits but also developmental progress and a sustainable environment. In our pursuit to comprehend the state of ambient air quality, our study zoomed in on the peripheral industrial areas of Ahmedabad city in Gujarat, India. These areas, representing the bustling industrial zones of Ahmedabad, became the focal point of our analysis. With utmost care, we strategically selected five sampling sites, alongside a control site, based on traffic density — a pivotal factor shaping our investigation. Our gaze then shifted towards the concentration of key pollutants NOx, SOx, PM 10, and PM 2.5 measured in the ambient air. The range of these pollutants varied between 22.63 µg/m3 and 112 µg /m3 for NOx, 10.78 ug/m3 and 88.50 µg /m3 for SOx, 8.70 µg /m3 and 51.30 µg /m3 for PM10, and 13.53 µg /m3 and 38.50 µg /m3 for PM 2.5. These figures serve as tangible evidence, shining a light on the concerning state of pollution plaguing the region. However, our endeavour transcended the mere numerical analysis. We dived deeper, exploring the intricate relationship between weather conditions and air quality. In deciphering general patterns, average values, and trends of wind direction and seasonal variations, we unearthed hidden insights. This holistic approach granted us a comprehensive understanding of the interplay between varying weather conditions and the quality of the ambient air. To provide a meaningful context, we compared our findings with the National Ambient Air Quality Standards (NAAQS), allowing us to interpret the state of the ambient air quality in the context of established guidelines. The results and subsequent discussion shed light on the implications of our findings, providing a foundation for informed decision-making and potential interventions to address this pressing issue.
Robotics for electric vehicles battery packs disassembly towards sustainable remanufacturing
Authors: Villagrossi Enrico , Dinon Tito 
Published: July 2023

Abstract
The automotive industry is involved in a massive transformation from standard endothermic engines to electric propulsion. The core element of the Electic Vehicle (EV) is the battery pack. Battery pack production misses regulations concerning manufacturing standards and safety-related issues. In such a fragmented scenario, the increasing number of EVs in circulation is growing exponentially, opening new challenges for managing the end-of-life of their battery packs.
This paper analyses the use of robotics for EVs' battery pack disassembly to enable the extraction of the battery modules preserving their integrity for further reuse or recycling. The analysis highlights that a complete automatic disassembly remains difficult, while human-robot cooperative disassembly guarantees high flexibility and productivity. The paper introduces guidelines for designing a robotic cell to disassemble a battery pack in collaboration with an operator. The design of the workcell evaluates the technological requirements for disassembly, the analysis of potentially explosive atmospheres (ATEX) of the area around the battery pack, and the design and optimisation of robotics tools in the ATEX zone. The work proposes solutions according to the current international standards.