bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical use, safety and effectiveness of novel high cost anticancer therapies after marketing approval: a record linkage study
Authors: Negri Eva , Rossi Marta , Bonifazi Martina , Franchi Matteo , Carioli Greta , Zocchetti Carlo , Corrao Giovanni , La Vecchia Carlo 
Published: April 2023

Background: major clinical outcomes of anticancer drugs may differ between clinical trials and clinical practice. Administrative databases provide long-term information on safety and effectiveness of these drugs in large unselected populations and in selected subgroups of patients. In addition, these data provide complementary information on topics where evidence from randomized clinical trials is unavailable.
Methods: this project will investigate 17 new targeted high cost drugs in Lombardy oncology practice between 2006 and 2010 using data from electronic healthcare databases. Specific objectives are: 1) to estimate the incidence of serious adverse events in clinical practice and their predictors; 2) to estimate survival and progression free survival and their predictors; 3) to compare major clinical outcomes according to different regimen of therapy. We will build a database by record linkage of several regional health service sources: the File F registry (in which the administration of the 17 drugs is recorded), the Regional hospital discharge forms (SDO ) database, the drug prescription database, the outpatients' services database, and the Registry Office database. Subjects resident in Lombardy who received at least one prescription of these drugs from 2006 to 2010 will be considered. Complications warranting hospitalization will be derived from the patients' SDO s after the first drug administration. Vital status will be obtained from the Registry Office database.
Results: we will provide estimates of the incidence of serious adverse events of novel anticancer therapies, and of overall and disease free survival in clinical practice, overall and in selected subgroups.
Conclusions: these data will contribute to a better effectiveness evaluation, particularly in patients under-represented in clinical trials.
Charles Everett Koop: the “Family doctor of America”
Authors: Bucci Roberto , Colamesta Vittoria , La Torre Giuseppe 
Published: April 2023

Charles Everett Koop was a great Surgeon General, probably the most influential in the history of the United States of America. He never missed courage in his life and often he had used it to tackle professional and personal tough problems.
In his public activity, he faced controversial health problems of American people as smoking, abortion and the first occurrence of the epidemic Acquired Immune Deficiency Syndrome (AIDS). Koop was a rigorous man. The lodestar that guided Koop in his work, as a public servant was to do the best for health of Americans. In his prestigious and difficult role, he faced the pressing problems of health of millions of people trying to avoid political influence. During his mandate of eight years, Koop increased the influence and authority of his role. His appearance and behaviour were unmistakable: Lincolnesque beard and uniform, conduct hard and pure, exclusively oriented to the health of citizens, over the personal conveniences, political pressure and lobbying. An exemplary man, who for his passion for medicine and his sincere interest in promoting public health, was affectionately considered the "Family Doctor of America".
The relationship between sleep time and self-rated health: an analysis based on Italian survey data
Authors: Citoni Guido 
Published: April 2023

Background: a growing and broadly discussed literature has shown that the relationship between sleep duration and health is not linear. Not only are insomnia and insufficient sleep harmful to one’s health, but excessive sleep too is also not beneficial. This study tests the association between selfrated state of health and the duration and pattern of sleep: we discuss the losses and costs in terms of quality of life deriving from excessive sleep time.
Methods: we use an ordered probit specification, applied to the Italian Survey on the Use of Time (sample of Italians aged fifteen and over who keep a diary for a working day).
Results: we show that greater sleep duration is negatively correlated both with self-reported state of health and with self-reported health satisfaction, while respondents’ subjective perceptions of too much and too little sleep are associated with health conditions in the usual u-shaped way.
Conclusions: the negative impact of long sleep on self-reported health is confirmed. However, the effect of short sleep on health conditions is positive, while a measure of decreasing sleep quality - comprising number of interruptions of sleep, insomnia and napping - is correlated to some extent with decreasing health. The public health consequences are still to be explored: the potential gains from sleep restriction are substantial, but little is known about the causal link or the risks. Further research is needed before taking policy decisions.
Allocating the Sample Size in Phase II and III Trials to Optimize Success Probability
Authors: De Martini Daniele 
Published: April 2023

Background Clinical trials of phase II and III often fail due to poor experimental planning. Here, the problem of allocating available resources, in terms of sample size, to phase II and phase III is studied with the aim of increasing success rate. The overall success probability (OSP) is accounted for.
Methods Focus is placed on the amount of resources that should be provided to phase II and III trials to attain a good level of OSP, and on how many of these resources should be allocated to phase II to optimize OSP. It is assumed that phase II data are not considered for confirmatory purposes and that are used for planning phase III through sample size estimation. Being $r$ the rate of resources allocated to phase II, $OSP(r)$ is a concave function and there exists an optimal allocation $r_{opt}$ giving $\max\{OSP\}$. If $M_I$ is the sample size giving the desired power to phase III, and $kM_I$ is the whole sample size that can be allocated to the two phases, it is indicated how large $k$ and $r$ should be in order to achieve levels of OSP of practical interest.
Results For example, when 5 doses are evaluated in phase II and 2 parallel phase III confirmatory trials (one-tail type I error $=2.5\%$, power $=90\%$) are considered with 2 groups each, $k=24$ is needed to obtain $OSP\simeq 75\%$, with $r_{opt}\simeq 50\%$. The choice of $k$ depends mainly on how many phase II treatment groups are considered, not on the effect size of the selected dose. When $k$ is large enough, $r_{opt}$ is close to $50\%$. An $r\simeq25\%$, although not best, might give a good OSP and an invitingly small total sample size, provided that $k$ is large enough.
Conclusions To improve the success rate of phase II and phase III trials, the drug development could be looked at in its entirety. Resources larger than those usually employed should be allocated to phase II to increase OSP. Phase II allocation rate may be increased to, at least, 25\%, provided that a sufficient global amount of resources is available.
Does economic crisis affect prevention services? An Italian region as a study case
Authors: De Vito Corrado , Di Marco Marco , Marzuillo Carolina , Matarazzo Azzurra , Massimi Azzurra , Villari Paolo 
Published: April 2023

Background: The Latium Region in Italy is currently under pressure from national government to achieve economic consolidation of regional health services and is subject to a formal regional recovery plan.
Methods: Using recognized health indicators together with a government assessment tool, we evaluate the impact of the economic downturn on the health of the Latium Region population.
Results: We find that healthcare spending in the Latium Region needs to become more efficient by improving primary healthcare and by restoring efficiency in hospitals.
Conclusions: Prevention activities should not only be defended in the current financial and economic crisis, but also streamlined and strengthened.
Prevalence and determinants of diabetes mellitus in a representative sample of Italian adults
Authors: Asciutto Rosario , Lugo Alessandra , Gallus Silvano , Roncaglioni Maria Carla , La Vecchia Carlo , Bosetti Cristina 
Published: April 2023

Background: Diabetes mellitus is a dramatic epidemic worldwide. This study providea an updated estimate of itsprevalence and determinants among Italian adults.
Methods: Data were derived from a face-to-face survey conducted in 2013 on 2901 individuals (1391 men, 1510 women) aged ≥18 years, representative of the general adult Italian population. Odds ratios (OR) for diabetes versus non diabetes in relation to selected risk factors were derived using multiple logistic regression models.
Results: Overall, 135 out of 2901 adults (4.7%) reported a diagnosis of diabetes, with similar prevalence in men (4.8%) and in women (4.5%). Diabetes increased with age (0.6% at age 18-44, 5.1% at age 45-64, and 11.3% at age ≥65 years; p-trend <0.001) and decreased with increasing level of education (12.8% for low, 7.8% for middle, and 1.4% for high education; p-trend <0.001). Prevalence was higher among obese subjects (10.8%) compared to normal weight subjects (3.1%; OR=2.46; p-trend=0.001), among individuals reporting a physical activity <30 minutes of walk/day (5.6%) compared to those reporting >60 minutes of walk/day (3.8%; OR=1.43), and among ex-smokers (11.6%) compared to never smokers (4.2%; OR=2.51); moreover, it was lower among moderate drinkers (3.1%) than among abstainers (6.1%; OR=0.57; p-trend=0.016). Prevalence of diabetes was 16.1% in individuals with a diagnosis of hypertension (OR=4.66), 15.2% in those with high cholesterol (OR=3.84), and 21.6% among aspirin users (OR=4.46).
Conclusion: Although diabetes prevalence in Italy is still comparatively low, effective clinical and preventive intervention strategies – focused on major risk behaviors – should be implemented to control the diffusion of this condition.
PERANCANGAN KOMPONEN STRUKTUR PENYUSUN BANGUNAN DENGAN PENDEKATAN CIRCULAR ECONOMY DAN KONSEP “EDITABLE MODULAR BUILDING”
Authors: Handali Kevin , Suteja Mekar Sari 
Published: April 2023

Tanjung Pasir Village is a village located north of Tangerang, Banten. Residents in this village have a unique habit of the buildings. They are used to building the house gradually in the core areas (bedrooms, kitchen and living room) then adding other rooms over time. This habit has a negative impact on development activities that are not running effectively and efficiently. A lot of material is wasted even though it can still be reused to minimize expenses during construction. By using the Circular Economy principle, namely the use of multifunctional materials, namely reusing existing materials with different functions. This principle works in extending the duration of material use. This design idea was inspired by the formation of LEGO which was created in 1949 and has a consistent shape and connection so that it can still be played today. The design concept is made simple modular which is manageable and sustainable. Application of the principle to this concept occurs in the use of permanent, semi-permanent, variable components and members of constant MEP structures.
Keywords: Circular Economy; component; lego; recycled material; structure
Abstrak
Desa Tanjung Pasir merupakan desa yang terletak di utara Tangerang, Banten. Penduduk di desa ini memiliki kebiasaan yang unik pada bangunan-bangunannya. Mereka terbiasa untuk membangun rumah secara bertahap pada area inti (kamar tidur, dapur, dan ruang keluarga) kemudian menambahkan ruang-ruang lain dengan berjalannya waktu. Kebiasaan ini memberikan dampak buruk terhadap kegiatan pembangunan yang berjalan secara tidak efektif dan efisien. Banyak material yang terbuang sia-sia padahal masih dapat dipakai kembali untuk meminimalisir pengeluaran saat pembangunan. Tulisan ini mencoba menggagas prinsip Circular Economy dalam mendesain suatu struktur penyusun bangunan. Konsepnya adalah penggunaan kembali material yang sudah ada agar multifungsi. Prinsip ini bekerja dalam memperpanjang durasi pemakaian material. Ide desain ini terinspirasi dari bentukan LEGO (tahun 1949) yang memiliki bentuk dan sambungan yang konsisten sehingga tetap bisa dimainkan hingga saat ini. Konsep desain dibuat modular sederhana yang dapat diatur dan berkelanjutan (editable modular). Penerapan konsep ini pada penggunaan struktur permanen, semi-permanen, komponen yang dapat diubah serta bagian struktur MEP konstan.
PELATIHAN PEMBUATAN WATER IONIZER UNTUK SISWA DAN GURU JURUSAN TEKNIK TENAGA LISTRIK SMK MERDEKA KOTA BANDUNG
Authors: Kurniawan Ekki , Pangaribuan Porman , Rodiana Irham Mulkan , Rachamat Noer , Raihan Fawwaz M , Aprianto Aldi , Sadewo Adyatma Hugo , Yudhistira Arie , Suryadin Ahmad , Prina Dian 
Published: April 2023

Tahun 2045 Indonesia diproyeksikan akan menjadi negara maju, dengan ekonomi terbesar ke-4 di dunia. Prediksi tersebut dilatarbelakangi dengan bonus demografi yang akan terjadi pada tahun 2030-2040. Hal ini merupakan keuntungan jika berhasil mendidik generasi mudanya. Sebaliknya akan menjadi “bencana” apabila kualitas masyarakat Indonesia tidak disiapkan dengan baik. Salah satu upaya untuk mencapai keuntungan ini adalah dengan memperhatikan tingkat kesehatan. Pada tahun 2021 indeks rata-rata kesehatan global sebesar 40,2 poin. Indonesia berada di posisi keempat Asia Tenggara (peringkat 30 dunia) di bawah Thailand, Singapura dan Malaysia. Masalah lainnya adalah masih banyaknya alumni SMK yang menganggur, sehingga tingkat kesehjateraannya masih kurang. Program pengabdian masyarakat ini adalah program pengabdian masyarakat lanjutan yang dilakukan pada siswa dan guru di SMK Merdeka Bandung. Pengabdian masyarakat ini berupa pelatihan membuat alat Portable Water Ionizer (PWI). PWI menghasilkan air alkali yang mengandung gas hidrogen, bermanfaat untuk menghasilkan antioksidan. Air asam yang dihasilkan dapat dimanfaatkan sebagai antiseptik dan desinfektan. Air alkali memiliki kandungan ion kalsium, magnesium, natrium,dan kalium lebih banyak dari air biasa sehingga dapat menguatkan tulang, sendi, otot, dan melancarkan peredaran darah. Siswa SMK diharapkan dapat memproduksi PWI secara masal, untuk dapat dikomersialkan. Dengan demikian diharapkan tingkat pengangguran alumni SMK Listrik bisa menurun, dan sekaligus juga kesejateraan dan kesehatan masyarakat akan meningkat. Hasil dari program ini berupa 30 unit PWI, yang telah teruji dapat menghasilkan air hidrogen, air alkali, dan air asam yang bermanfaat untuk kesehatan.Kata Kunci: Indonesia, Kesehatan, SMK,Portable Water Ionizer, Masyarakat
PENINGKATAN MOTIVASI BELAJAR MELALUI PELATIHAN MOTIVASI PADA SISWA SMK YPPS SUMEDANG
Authors: Dudija Nidya , Indiyati Dian , Pratomo Triaji Prio 
Published: April 2023

Motivasi belajar merupakan salah satu aspek penting yang perlu menjadi perhatian pada perkembangan remaja selaku siswa menengah atas. Motivasi memegang peranan penting untuk meningkatkan prestasi akademik siswa, terlebih pada siswa SMK yang memiliki orientasi bekerja setelah lulus sekolah. Kegiatan pengabdian masyarakat berupa pelatihan/penyuluhan dilakukan berkolaborasi antara Fakultas Ekononi Bisnis dan Fakultas Komunikasi Bisnis dengan masyarakat sasar 83 siswa SMK YPPS jurusan tata boga, busana dan perhotelan. Kegiatan pengabdian masyarakat ini memberikan wawasan dan penyuluhan terkait pengembangan diri dan peningkatan motivasi belajar. Pada kegiatan ini peserta mengisi kuesioner motivasi belajar yang terdiri dari 12 aitem pernyataan terkait motivasi intrinsik dan ekstrinsik. Diperoleh hasil melalui analisis deskriptif motivasi siswa SMK YPPS Pariwisata Sumedang berada pada kategori Tinggi sebesar 82,3%. Hasil pengabdian masyarakat dan penelitian ini tentunya dapat menjadi acuan dan pengetahuan kepada para guru di SMK YPPS dalam memberikan materi ajar dan mengembangkan kegiatan belajar yang menarik sehingga mampu meningkatkan motivasi belajar siswa dan membantu siswa untuk mengenali dirinya dan melakukan pengembangan diri, sehingga siswa – siswa YPPS dapat tumbuh menjadi pribadi yang unggul dan percaya diri untuk mencapai cita – citanya. Kata Kunci: Motivasi Intrinsik, Motivasi Ekstrinsik
PEMBELAJARAN LITERASI DIGITAL PARA PEJUANG DAKWAH LPD AL BAHJAH CIREBON
Authors: Anggraini Clara Novita , Pertiwi Mirah , Rustandi Dudi , Aprilianza Devi Tri , Ramadhani Ocha Tisepta , Aksamala Dewa Ayu 
Published: April 2023

Setiap tahunnya, trend pengguna internet di Indonesia terus mengalami peningkatan. Akan tetapi, kenaikan signifikan tidak dibarengi dengan penguasaan terhadap dampak yang ditimbulkannya. Misalnya belum mampunya membedakan antara informasi yang kredibel dan berita bohong (hoaks). Tingkat kemunculan hoaks yang cukup tinggi kebanyakan merupakan informasi yang memiliki irisan dengan agama. Oleh karena itu, para Pejuang Dakwah memiliki peran signifikan dalam mendorong pemberantasan hoaks melalui dakwah. Pada dasarnya hoaks sangat bertentangan dengan agama. Oleh karena itu, Telkom University bekerja sama dengan Lembaga Pendidikan Dakwah (LPD) Al-Bahjah menyelenggarakan pembelajaran literasi digital dakwah untuk para pejuang dakwah. Pejuang dakwah LPD Al Bahjah adalah para santri yang mengelola media siar sebagai sarana dakwah secara digital. Media yang dikelola antara lain youtube, Instagram, dan radio. Berdasarkan hasil observasi selama kegiatan PKM ini berlangsung, kegiatan pembelajaran literasi digital dakwah bagi pejuang dakwah LPD Al-Bahjah telah bermanfaat dalam menambah pengetahuan, serta meningkatkan skill literasi digital dakwah para pejuang dakwah LPD Al-Bahjah. Kata Kunci: Literasi Digital, Pejuang Dakwah, LPD Al-Bahjah
Uma análise das principais causas de cegueira em bebês: catarata congênita e retinopatia da prematuridade
Authors: Ourofino Eder da Silva , Sgarbi Mariana Teixeira , Sgarbi Maria Clara Teixeira , Siqueira Emílio Conceição de 
Published: April 2023

Objetivo: Analisar as características da Catarata Congênita (CC) e da Retinopatia da Prematuridade (ROP). Revisão bibliográfica: A deficiência visual na criança impacta o desenvolvimento, gerando desvantagens nos processos educativos, independência, aprendizagem e adaptação. Em todo o mundo as principais causas de baixa visual na primeira infância são a ROP e CC. Em países de baixa e média renda, predomina a catarata CC e, em países de baixa renda, ROP. A ROP é ​​uma vitreorretinopatia proliferativa que afeta bebês prematuros e é uma das principais causas de cegueira infantil em todo o mundo, já a CC é definida como qualquer opacidade do cristalino presente no nascimento ou na primeira infância. Considerações finais: A catarata congênita e a retinopatia da prematuridade constituem as principais causas de baixa visual e cegueira na primeira infância. Nesse contexto, é essencial a implementação dos testes de triagem no caso da CC o teste do reflexo vermelho e no caso da ROP com exames de fundo de olho nos recém-nascidos prematuros abaixo de 1.500 g ou com IG <30 semanas. Dessa forma, oportunizando um diagnóstico precoce é possível reduzir as sequelas de ambas as patologias.
Klippel-Trenaunay syndrome: A case report of orthodontic-surgical treatment
Authors: Tehranchi Azita , Tabrizi Reza , Rafsanjan Katayoun Talebi 
Published: April 2023

Introduction:
Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by a clinical triad of capillary malformation; varicose veins; and soft tissue and/or bony hypertrophy. This rare syndrome has an estimated incidence of about 2–5/100,000 live births. KTS usually affects the extremities but occasionally can manifest in the craniofacial region, including the oral cavity.

Case Presentation:
Our patient, a 17-year-old girl, presented with large areas of port wine stain, unilateral hypertrophy of the facial region, and varicose veins. She was diagnosed with KTS. Orthodontic treatment followed by orthognathic surgery was performed to address her complaint of facial asymmetry and poor chewing efficacy. Treatment resulted in significant improvement in her appearance and dental occlusion and our patient was very satisfied with the results.

Conclusion:
This report illustrates an orthodontic and surgical treatment approach of a case with KTS. Effective management of orthodontic and facial manifestations of KTS considerably enhances the patient’s function, appearance, and overall quality of life.
Evaluation of The COVID-19 Vaccination Program for the Elderly in the Rawalo Health Center With the CIPP (Context, Input, Process, And Product) Model
Authors: Gunanto Gunanto , Septo Pawelas Arso  , Rani Tiyas Budiyanti  
Published: April 2023

Rawalo sub-district had a relatively high number of COVID-19 cases compared to other sub-districts in Banyumas Regency. The government provides COVID-19 vaccination which aims to reduce the number of COVID-19 cases by forming Herd Immunity in the community. The elderly are a group at high risk of morbidity and mortality due to exposure to COVID-19. However, the coverage of COVID-19 vaccination for the elderly at the Rawalo Health Center is still relatively low. This study was aimed to evaluate the program with the CIPP (Context, Input, Process, Product) model in a complex and comprehensive manner regarding how the implementation of the COVID-19 vaccination program in the elderly. This research was a qualitative study with a descriptive approach using observation and in-depth interview methods selected by purposive sampling technique. The research subjects as the main informants included the Head of the Puskesmas, the Head of the COVID-19 Vaccination Program Team, the COVID-19 Vaccination Coordinator and health cadres. Meanwhile, the elderly group and the Banyumas Regency Health Office as triangulation informants. The results showed that vaccination coverage in the elderly was still low, at 10% for dose 3. This was due to less thorough education, lack of human resources (vaccination officers), and ineffective coordination, there is data that is not synchronous or valid. There are technical and non-technical obstacles in recording and reporting. Thus, improvements need to be made to aspects that affect the vaccination implementation process and low coverage.
Pelatihan Aplikasi Android MH (Morbus Hansen) Mobile Pada Penderita Kusta dan Keluarga
Authors: Aditya Ronal Surya , Kodriyah Lailatul , Afiani Nurma , Sunaryo Eri Yanuar Akhmad Budi , Sulistyorini Anita , Soelistyowati Endang 
Published: April 2023

Introduction:Kusta adalah penyakit infeksi kronis yang disebabkan oleh Mycobacterium leprae, ditandai dengan sangat panjangnya masa inkubasi, kesulitan dalam mendeteksi tanda dan gejala. Indonesia menduduki urutan ketiga setelah India dan Brazil dengan jumlah penderita kusta sebanyak 20.023 kasusObjectives: membentuk kampung ramah kusta, dimana mereka tidak akan melakukan stigma pada penderita kusta, dengan cara memandirikan perawatan penderita kusta dengan memaksimalkan support sistem yang ada di sekitar penderitaMethods: Metode yang dilakukan dalam pengabdian masyarakat ini adalah pelatihan yang melalui 3 tahap, yaitu persiapan, pelaksanaan dan evaluasiResults: penderita, keluarga dan kader beserta perawat penanngung jawab dan perawat desa mendapatkan pengetahuan terkait dengan aplikasi kusta, serta berkomitmen untuk meningkatkan derajat kesehatan penderita kustaConclusions: Program pengabdian pada masyarakat ini bertujuan untuk memberikan pelatihan penggunaan aplikasi kepada penderita kusta dan keluarga. Target yang hendak dicapai dalam program ini adalah peserta mampu mengetahui dan menggunakan aplikasi untuk peningkatan derajat kesehatan mereka. Hasil yang dicapai berupa kemampuan penderita kusta dan keluarga dalam meningkatkan derajat kesehatan mereka.