bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis
Authors: Fu Chang , Li Xiaocong , Chen Yongjin , Long Xiaoyin , Liu Kai 
Published: June 2023

AbstractBackgroundLiver transplantation has made significant progress in recent decades. Lung cancer is one of the most frequently occurring cancers after liver transplantation. However, the risk of lung cancer among liver transplant patients compared with the general population is unclear. The aim of this meta‐analysis was to assess the risk of developing lung cancer after liver transplantation.MethodsAll eligible studies published in PubMed, Web of Science, and Embase from database inception to April 2022 were included. Standardized incidence ratio was used to describe the increased risk of lung cancer in liver transplant recipients as compared with the general population. The random‐effects model was used for the calculations. A funnel plot and Egger test were performed to assess the potential publication bias.ResultsOur meta‐analysis included 15 studies, which involved 76,897 liver transplantation patients. Studies included in this review showed significant heterogeneity (I2 = 65.3%; p < 0.001), which required a random‐effects model for effect pooling. The results indicated a significant higher risk of developing lung cancer in liver transplant patients than the general population with a pooled SIR of 2.06 (95% CI: 1.73, 2.46, p < 0.001). When stratified by region, no significant regional difference was observed. It showed a similarly doubled risk of lung cancer in Europe and North America, but an insignificantly increased risk in Asian populations. The sensitivity analysis by removal and substitution of each literature did not change the results.ConclusionOur meta‐analysis suggests that liver transplant patients are twice as likely as the general population to develop lung cancer. Further research on risk factors for the development of lung cancer after liver transplantation should be conducted and appropriate surveillance protocols should be developed to reduce the risk of its occurrence.
Health status and mental distress in people with cancer and comorbid conditions: The Australian National Health Survey analysis
Authors: Ng Huah Shin , Woodman Richard , Koczwara Bogda 
Published: June 2023

AbstractIntroductionData on the impact of specific comorbidities on health outcomes is limited. We compared health status and mental distress between individuals with and without cancer according to comorbidity type.MethodsA cross‐sectional analysis using data from the Australian National Health Survey 2017–18 including all respondents aged ≥25 years with and without a history of cancer. The odds of poor health and mental distress were reported according to cancer status, and specific individual and cluster of comorbidities.ResultsThere were 1982 individuals (52% female) with cancer and 12,635 (51% female) without cancer. Individuals with cancer were older, and more likely to have a comorbidity compared with those without cancer. They were more likely to report poor health than those without cancer for each specific comorbidity; except for skin conditions and infectious diseases; with the adjusted odds ratio (aOR) ranging from 1.34 (95% CI = 1.01–1.79) for digestive disorders to 2.93 (95% CI = 1.62–5.29) for blood conditions. The strongest association with poor health (aOR 2.79, 95% CI = 2.27–3.43) and mental distress (aOR 9.01, 95% CI = 7.25–11.20) was observed for those with a comorbid mental illness. Exploratory cluster analysis identified four distinct comorbidity clusters: low comorbidity, musculoskeletal, respiratory and cardiometabolic; cancer survivors in the cardiometabolic cluster had a higher odds of reporting poor health (aOR 3.50, 95% CI = 2.48–4.92) and mental distress (aOR 2.33, 95% CI = 1.53–3.55) than those with a low comorbidity.ConclusionsComorbidities in cancer survivors were common and associated with inferior health status, although the magnitude of the effect varied by comorbidity type. Risk assessment and management of comorbidities should be an important priority for cancer care and research.
Nonlinearity of healing: Healing narratives of Filipino therapists‐in‐training who self‐identify as wounded healers
Authors: Dee Ariana Denise A. , Fernandez Karina Therese G. 
Published: June 2023

AbstractDue to the stigma therapists‐in‐training face within the field owing to their woundedness, and the dearth of psychological literature on the healing of wounded healers (WHs), this study examined the healing journeys of nine Filipino therapists‐in‐training who self‐identify as WHs. Narrative Identity framework was utilized to analyse the healing narratives gathered from nine semi‐structured interviews with therapists‐in‐training. Results focussed on the healing narratives and how these shaped the identity and development of these future practitioners. The healing narratives of therapists‐in‐training were generally composed of four chapters: (a) identifying the wounded‐client identity and its wounds, (b) entering the counselling field brings the emergence of the healer‐therapist identity, (c) nonlinearity of healing transforms into a fluid WH, and (d) continuing the healing journey. These never‐ending and nonlinear journeys shaped how therapists‐in‐training perceived and constructed or deconstructed their identification, with their dual identities influencing their practice. Additionally, their healing journeys contributed to their development as therapists who continue to heal from their woundedness. This study contributes to the literature regarding therapists‐in‐training who self‐identify as WHs through the emphasised healing process. Moreover, this study may both lessen the stigma surrounding therapists‐in‐training's woundedness and help colleagues, educators, mentors and supervisors within the counselling field to better help trainees through the creation of open spaces, classes and training programmes that may help in enhancing their well‐being and utilising their woundedness to increase, rather than impair, their therapeutic ability.
Anatomic suitability for transapical transcatheter mitral valve implantation using a tether‐based device
Authors: Blanke Philipp , Modine Thomas , Duncan Alison , Taramasso Maurizio , Dumonteil Nicolas , Chuang Michael L. , Conradi Lenard 
Published: June 2023

AbstractBackgroundTranscatheter mitral valve implantation (TMVI) is a novel therapeutic option for treating symptomatic mitral valve disease. Evaluating patient anatomical suitability is a critical step in the TMVI screening process, but currently requires specialized software and computerized device models.AimsThis analysis sought to assess the effectiveness of simple and standardized multislice computed tomography (MSCT) anatomic measurements for their ability to discriminate between patients who passed anatomical screening for Tendyne™ TMVI.MethodsSubjects screened for the Tendyne Expanded Clinical Study from January 2016 through September 2019 were included. Core laboratory screening measurements included mitral annular (MA) dimensions at end‐systole and end‐diastole, simulated device implantation, and neo‐left ventricular outflow tract (LVOT) area. Additionally, nine standard measurements of patient anatomy were assessed for their predictive value of patients passing the anatomic screening process.ResultsOut of 496 subjects screened for eligibility, 257 subjects met clinical eligibility criteria with MA dimensions within the manufacturer's suggested range: 153 (59.5%) underwent TMVI while 104 (40.5%) were excluded from the study for other anatomic reasons (76% due to risk of LVOT obstruction). CT‐derived left ventricular end‐systole diameter (LVESD) had the highest discriminatory power for predicting TMVI anatomical suitability (area under the curve of 0.908, p < 0.0001). The mitral inter‐commissural (IC) dimension was best predictive of annular dimensions being within range, with dimensions <30 or >50 mm resulting in a negative predictive value of 94.4%.ConclusionsMSCT‐derived mitral IC dimension and LVESD easily performed measures that are effective predictors of anatomical suitability or screen failure for this tether‐based TMVI device.
Hypertrophic cardiomyopathy in an adult patient with Noonan syndrome with multiple lentigines
Authors: Rivero‐García Pamela , Campuzano‐Estrada Isabel del Carmen , Hernandez‐Felix Jorge Humberto 
Published: June 2023

Key Clinical MessageNoonan syndrome with multiple lentigines (NSML) is a rare RASopathy caused by pathogenic variants (PV) predominantly in PTPN11 gene. We report a 54‐year‐old male with apical hypertrophic cardiomyopathy, who was diagnosed with NSML due to his short stature, multiple lentigines, winged neck, pectus excavatum, and a heterozygous PV in PTPN11 c.836A > ¡G.
Reversible paraparesis due to extramedullary hematopoiesis
Authors: Muharremi Eti , Djamandi Pavllo , Rroji Arben , Kruja Jera 
Published: June 2023

Key Clinical MessageExtramedullary hematopoiesis should be considered in the differential diagnosis of spastic paraplegia in a patient with thalassemia. Radiotherapy remains the treatment of choice, and regain of motor power is expected.
CO2 Radical Anion in Photochemical Dicarboxylation of Alkenes
Authors: Wang Sai , Xu Pei , Zhu Xu 
Published: June 2023

AbstractCO2 radical anion (CO2⋅−) is a highly reductive species (Ered=−2.2 V vs SCE), which can undergo Giese radical addition to an unsaturated C−C bond and install a carbonyl group to synthesize acids. Normally, it has been generated through the direct reduction of CO2 gas or from formate salts via HAT (hydrogen atom transfer) as the BDE (bond dissociation energy) of the C−H bond in formate is only around 86 kcal/mol. This concept highlights the recent developments on alkenes dicarboxylation reaction with CO2 and/or formate as the carbonyl sources. In these reactions, CO2 radical anion species played significant roles in the carboxylation step.
Zr‐Based Metal‐Organic Framework UiO‐66/Ultem® 1000 Membranes for Effective CO2/H2 Separation
Authors: Imad Muhammad , Castro-Muñoz Roberto , Bernauer Milan , Martin Violeta , Izak Pavel , Fila Vlastimil 
Published: June 2023

AbstractMixed‐matrix membranes (MMMs) using UiO‐66 nanofillers as dispersing inorganic phase and polyetherimide (PEI) as continuous polymeric matrix were synthesized. Different UiO‐66 loadings of 10, 20, and 30 wt % were applied. The morphology and UiO‐66 dispersion over the prepared MMMs were examined. Gas separation measurements were performed for H2/CO2 gas mixture to evaluate the influence of UiO‐66 on the separation yield of resulting membranes. When compared with pristine PEI membranes, MMMs containing metal‐organic framework (MOF) nanoparticles revealed superior H2 permeability and H2/CO2 separation factor, e.g., maximum permeability values of 14.6 and 5.5 Barrer were observed for H2 and CO2 at a filler loading of 10 wt % and an applied pressure of 4.0 bar.
Empowering workplace allies for lesbian, gay, bisexual, and transgender employees to prevent and minimize psychological distress: A scoping review
Authors: Ho Laurie Long Kwan , Cheung Ankie Tan , Chan Carlo Chak Yiu , Wong Eliza Lai Yi , Tam Wilson Wai San , Chien Wai Tong 
Published: June 2023

AbstractIntroductionLesbian, gay, bisexual, and transgender (LGBT) employees have increasingly reported experiencing different forms of workplace discrimination/harassment. Workplace allyship may be positively associated with psychological health through creating inclusive organizational cultures or reducing discrimination/harassment. However, comprehensive literature reviews or evidence syntheses on the effects of workplace allyship in mental health protection/promotion for LGBT employees are limited.MethodsThis scoping review aimed to summarize available evidence regarding the effectiveness of workplace allies for LGBT employees in preventing/minimizing psychological distress and clarify the therapeutic components. This review included published research articles and grey literature identified through 11 electronic databases, a secondary search, and other sources.ResultsWe identified 27 relevant articles. Most included studies used cross‐sectional or qualitative research designs, and evidence from countries beyond the United States was limited. Three essential/effective components of workplace allies/allyship were identified that could create supportive/safe workplace relationships/climates: (a) knowledge, (b) empathy, and (c) action.ConclusionsFurther longitudinal studies and controlled trials are needed to increase the quality of evidence on the effects and change processes induced by workplace allyship. Qualitative studies are also recommended to understand the health needs and mechanism of actions of workplace allyships in different LGBT communities.
Stereoselective Intramolecular [2+2] Trapping of 1,2‐Cyclohexadienes: a Route to Rigid, Angularly Fused Tricyclic Scaffolds
Authors: Jankovic Christian L. , McIntosh Kyle C. , Lofstrand Verner A. , West F. G. 
Published: June 2023

Abstract1,2‐Cyclohexadienes generated under mild fluoride‐mediated desilylative conditions undergo efficient intramolecular [2+2] trapping, providing tricyclic alkylidene cyclobutanes with complete diastereoselectivity for the cis‐fused products. Pendent styrenes or electron‐deficient olefins can trap simple 1,2‐cyclohexadienes or their oxygenated counterparts, with 14 substrates being disclosed. Reactions proceed at ambient temperature using just cesium fluoride in up to 91 % yield, and the necessary precursors are easily accessed from substituted 2‐bromocyclohexenones. Multiple synthetic routes have been developed to install the appropriate functional groups required for [2+2] trapping.
Borylated Subphthalocyanines: Versatile Precursors for the Preparation of Functional Bowl‐Shaped Aromatics
Authors: Gómez‐Gómez Marta , Labella Jorge , Torres Tomás 
Published: June 2023

AbstractThe peripheral borylation of porphyrinoids has become a key step to prepare advanced functional materials. This study reports the synthesis, electronic properties, and reactivity of borylated subphthalocyanines. These compounds, which are prepared by Suzuki–Miyaura borylation in excellent yields, are easily purified, display a great stability, and serve as powerful starting materials for the post‐functionalization of SubPcs via cross‐coupling reactions. Remarkably, this novel approach is more efficient than the methodologies already described and enables the preparation of exotic systems, such as SubPc dimeric species linked by C−C bonds, which are not accessible so far and present promising properties for optoelectronic devices.
Concept of Catalytic Depolymerization of Polyolefinic Plastic Waste to High Value Chemicals
Authors: Schröter Stephan , Rothgänger Thomas , Heymel Dirk , Seitz Mathias 
Published: June 2023

AbstractTo establish a circular economy the chemical recycling of plastic waste seems to be crucial as contaminated waste streams cannot be easily recycled by mechanical processes. Some plastic components and contaminants cause severe problems in thermo‐chemical processes and the refining of the intermediates, which leads to a crucial waste pretreatment. Therefore, robust and efficient conversion methods have to be developed. A contribution to this, a new concept regarding the catalytic conversion of plastic waste, the necessary refining steps and ecological considerations, is proposed in this work.
Prospective LCA of Waste Electrical and Electronic Equipment Thermo‐Chemical Recycling by Pyrolysis
Authors: Schulte Anna , Lamb-Scheffler Moema , Biessey Philip , Rieger Tobias 
Published: June 2023

AbstractWaste electrical and electronic equipment (WEEE) is a particularly difficult waste to manage, characterized by hazardous and valuable chemicals. Emerging chemical recycling technologies are developed to unveil the possibility of sustainable treatment providing valuable resources from WEEE. This study develops a framework for prospective life cycle assessment (LCA) to explore a range of future scenarios in which the technology can be operated with low environmental impact. This is demonstrated in a case study focusing on plastics from WEEE, which are currently predominantly incinerated. The results reveal environmental benefits by WEEE treated via chemical recycling. In terms of climate change impacts, the best‐case scenario of chemical recycling shows a reduction potential of 74 % compared to current treatment.
Safety and efficacy of durvalumab after concurrent chemoradiation in Black patients with locally advanced non–small cell lung cancer
Authors: McCall Neal S. , Janopaul‐Naylor James R. , McGinnis H. Scott , Kesarwala Aparna H. , Tian Sibo , Stokes William A. , Shelton Joseph W. , Steuer Conor E. , Carlisle Jennifer W. , Leal Ticiana A. , Ramalingam Suresh S. , Bradley Jeffrey D. , Higgins Kristin A. 
Published: June 2023

AbstractBackgroundThe PACIFIC trial established consolidative durvalumab after concurrent chemoradiation as standard‐of‐care in patients with stage III or unresectable non–small cell lung cancer (NSCLC). Black patients, however, comprised just 2% (n = 14) of randomized patients in this trial, warranting real‐world evaluation of the PACIFIC regimen in these patients.MethodsThis single‐institution, multi‐site study included 105 patients with unresectable stage II/III NSCLC treated with concurrent chemoradiation followed by durvalumab between 2017 and 2021. Overall survival (OS), progression‐free survival (PFS), and grade ≥3 pneumonitis‐free survival (PNFS) were compared between Black and non‐Black patients using Kaplan–Meier and Cox regression analyses.ResultsA total of 105 patients with a median follow‐up of 22.8 months (interquartile range, 11.3–37.3 months) were identified for analysis, including 57 Black (54.3%) and 48 (45.7%) non‐Black patients. The mean radiation prescription dose was higher among Black patients (61.5 ± 2.9 Gy vs. 60.5 ± 1.9 Gy; p = .031), but other treatment characteristics were balanced between groups. The median OS (not‐reached vs. 39.7 months; p = .379) and PFS (31.6 months vs. 19.3 months; p = .332) were not statistically different between groups. Eight (14.0%) Black patients discontinued durvalumab due to toxicity compared to 13 (27.1%) non‐Black patients (p = .096). The grade ≥3 pneumonitis rate was similar between Black and non‐Black patients (12.3% vs. 12.5%; p = .973), and there was no significant difference in time to grade ≥3 PNFS (p = .904). Three (5.3%) Black patients and one (2.1%) non‐Black patient developed grade 5 pneumonitis.ConclusionsThe efficacy and tolerability of consolidative durvalumab after chemoradiation appears to be comparable between Black and non‐Black patients.
AWC‐NIDS: Attack‐wise customized network intrusion detection system using machine learning, concurrency, and distributed systems
Authors: Güney Hüseyin 
Published: June 2023

SummaryWith digitization and modern network applications, information security has gained a tremendous importance. Therefore, accurate and efficient detection systems are crucial for maintaining proactive security in computer networks. Machine learning (ML) has shown great potential as a promising solution since it can teach a machine to distinguish malicious and normal network activities. However, recently proposed methods are suffering from at least one of the following: detection accuracy, false alarm rate, and computational complexity issues. The main reason behind this problem is the complexity of the model in terms of attack types. From the ML perspective, intrusion detection is a classification problem where each attack type is identified by a set of different features, and features are used for classifying network activities. Thus, training an ML algorithm to detect more than one attack type leads to a more complex model; the increasing number of used features contributes positively to the model complexity, and may result in relatively lower detection accuracy or a higher false positive rate. To tackle this problem, this study proposes an attack‐wise customized network intrusion detection system (AWC‐NIDS) based on ML, concurrency, and distributed systems to achieve accurate and efficient network‐wide intrusion detection. Since CICIDS2017 contains many modern attacks, it was used for model development and performance evaluation. The experimental results showed that the proposed methodology achieved high classification performance for all datasets with a small number of features. However, it was observed that the lowest accuracy was achieved for the comprehensive dataset (which contains all attack types); for the single attack‐type datasets, the obtained accuracy was above 99%. This finding proves the concept of attack‐wise customization for intrusion detection and shows the significance of the proposed methodology. In conclusion, this framework is promising for implementing robust and accurate cybersecurity systems for traditional and modern networking.
Production of Dihydrogen Using Ammonia Borane as Reagent and Pyrazole as Catalyst
Authors: Delgado Gómez Marta , Marazzi Marco , Elguero José , Ferrer Maxime , Alkorta Ibon 
Published: June 2023

AbstractTheoretical chemistry (DLPNO‐CCSD(T)/def2‐TZVP//M06‐2x/aug‐cc‐pVDZ) was used to design a system based on ammonia boranes catalyzed by pyrazoles with the aim of producing dihydrogen, nowadays of high interest as clean fuel. The reactivity of ammonia borane and cyclotriborazane were investigated, including catalytic activation through 1H‐pyrazole, 4‐methoxy‐1H‐pyrazole, and 4‐nitro‐1H‐pyrazole. The results point toward a catalytic cycle by which, at the same time, ammonia borane can initially store and then, through catalysis, produce dihydrogen and amino borane. Subsequently, amino borane can trimerize to form cyclotriborazane that, in presence of the same catalyst, can also produce dihydrogen. This study proposes therefore a consistent progress in using environmentally sustainable (metal free) catalysts to efficiently extract dihydrogen from small B−N bonded molecules.
Study on Preparation of Magnesium Hydroxide by Continuous Forced Circulation Process
Authors: Zhang Ying , Xia Liang , Zhang Li , Li Yaxia , Feng Ying , Zhang Jianwei 
Published: June 2023

AbstractA continuous process for preparation of magnesium hydroxide with a forced circulation tubular reactor is proposed. The residence time distribution of the liquid in the reactor at different flow rates is measured, and the parameters of the tanks‐in‐series model are obtained. Using soluble magnesium salt and ammonia as raw materials, magnesium hydroxide is prepared. The effect of the flow rates on the product quality is investigated. The results show that the smaller the flow rate, the longer the residence time of the liquid in the reactor and the better the dispersion and crystal morphology of the products. When the total volume of the reactor is 300 mL and the flow rates are 5–50 mL min−1, the values of the average residence time of the liquid are 3094–351 s and the parameters of tanks‐in‐series model are 1.05–1.52. The reactors are closer to the continuous stirred tank reactor. The average particle sizes of the magnesium hydroxide products are 2.32–2.47 µm, and the values of I001/I101 are 1.17–0.89. The crystal morphology is flaky. Being compared with that from magnesium sulfate, the magnesium hydroxide products from magnesium nitrate have smaller particle size and better dispersibility.