bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venetoclax plus hypomethylating agents in DDX41‐mutated acute myeloid leukaemia and myelodysplastic syndrome: Mayo Clinic series on 12 patients
Authors: Nanaa Ahmad , He Rong , Foran James M. , Badar Talha , Gangat Naseema , Pardanani Animesh , Hogan William J. , Litzow Mark R. , Patnaik Mrinal , Al‐Kali Aref , Alkhateeb Hassan B. 
Published: September 2023

SummaryVenetoclax (VEN) is an FDA‐approved selective inhibitor of B‐cell leukaemia/lymphoma‐2 (BCL‐2), used for treating elderly or unfit acute myeloid leukaemia (AML) patients unable to undergo intensive chemotherapy. Combining VEN with hypomethylating agents (HMAs) has shown impressive response rates in high‐risk myelodysplastic syndromes (MDS) and relapsed/refractory AML. However, the efficacy of VEN and HMAs in treating DDX41‐mutated (mDDX41) MDS/AML patients remains uncertain. Despite the favourable prognostic nature of mDDX41 MDS/AML patients, there is a lack of clinical experience regarding their response to different treatment regimens, leading to an unknown optimal therapeutic approach.
Synthesis, cytotoxicity, and antibacterial studies of 2,4,5,6‐substituted hexahydro‐1H‐isoindole‐1,3(2H)‐dione
Authors: Yetişkin Egehan , Gündoğdu Özlem , Mete Derya , Çelebioğlu Neslihan , Kara Yunus , Şanlı‐Mohamed Gülşah 
Published: September 2023

AbstractIn this study, synthesis of novel isoindole‐1,3‐dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against some cell lines. A multistep chemical pathway was used to synthesize the derivatives. The cytotoxic effect of trisubstituted isoindole derivatives were evaluated by determining cellular viability using the MTT assay against A549, PC‐3, HeLa, Caco‐2, and MCF‐7 cell lines. The C‐2 selective ring‐opening products were obtained from the ring‐opening reaction of 5‐alkyl/aryl‐2‐hydroxyhexahydro‐4H‐oxireno[2,3‐e]isoindole‐4,6(5H)‐diones with nucleophiles such as chloride (Cl−) and bromide (Br−) ions. In addition, the ring‐opening products halodiols were converted to their related acetates. The anticancer activity of synthesized isoindole‐1,3‐dione derivatives was investigated against HeLa, A549, MCF‐7, PC3, and Caco‐2 cells in vitro and resulted in varies cytotoxic effect depend on the group attached to the isoindole molecule. Furthermore, the evaluation of the antimicrobial action of trisubstituted isoindole derivatives against Gram‐positive (Staphylococcus aureus) and Gram‐negative (Escherichia coli) bacteria was assessed and found out selective inhibition of the both bacterial growth via different trisubstituted isoindole derivatives. The results of this work encourage further research on the potential utilization of trisubstituted isoindole derivatives as cytotoxic and antimicrobial agents.
Tandem bispecific CD123/CLL‐1 CAR‐T cells exhibit specific cytolytic effector functions against human acute myeloid leukaemia
Authors: Wang Xiang‐Yu , Bian Mei‐Ru , Lin Guo‐Qiang , Yu Lei , Zhang Yan‐Ming , Wu De‐Pei 
Published: September 2023

AbstractObjectivesThe treatment of refractory and recurrent acute myeloid leukaemia (AML) is still a challenge with poor response rates and short survival times. In an attempt to solve this problem, we constructed a tandem bispecific chimeric antigen receptor (CAR) targeting CD123 and C‐type lectin‐like molecule 1 (CLL‐1), two different AML antigens, and verified its cytotoxic effects in vitro.MethodsWe established and cultured K562 cell lines expressing both CD123 and CLL1 antigens. Single‐target CAR‐T cells specific to CD123 and CLL1 were engineered, alongside tandem CD123/CLL1 bispecific CAR‐T cells. Flow cytometry was used to determine cell phenotypes, transfection efficiencies, cytokine release, and CAR‐T‐cell proliferation, and an lactate dehydrogenase assay was used to detect the cytotoxicity of CD123/CLL‐1 bispecific tandem CAR‐T cells in vitro.ResultsTwo types of tandem CAR‐T cells exhibited significant killing effects on CLL‐1 + CD123+ leukaemia cell lines and primary AML tumour cells. The killing efficiency of tandem CAR‐T cells in the case of single antigen expression is comparable to that of single target CAR‐T cells. When faced with dual target tumour cells, dual target CAR‐T cells significantly surpass single target CAR‐T cells. CD123/CLL‐1 CAR‐T cells in tandem targeted and killed CD123‐ and CLL‐1‐positive leukaemia cell lines and released a large number of cytokines.ConclusionsCD123/CLL‐1 CAR‐T cells in tandem can simultaneously target CD123 and CLL‐1 on AML cells, demonstrating a significant ability to kill single antigens and multi‐target tumour cells. This suggests that CD123/CLL‐1 CAR‐T cells exhibit significant advantages in the expression of multiple antigens in a wide range of target cells, which may help overcome the challenges posed by tumour heterogeneity and evasion mechanisms.
Culturally humble and anti‐racist couple and family interventions for African Americans
Authors: Kaslow Nadine J. , Clarke Christina , Hampton‐Anderson Joya N. 
Published: September 2023

AbstractAnti‐Black racism including structural racism and racism‐related disparities have come to the foreground in recent years with the increasingly frequent and brutal police killings of innocent African Americans, the disproportionate impacts of the pandemic on the Black community, and the effectiveness of the Black Lives Matter movement. There have been calls to action to ensure cultural effectiveness of couples and family therapy for African Americans. As one response to these calls, this article provides recommendations for culturally humble and anti‐racist couple and family interventions. These best practices focus on the necessity of embracing a systemic stance and a strengths‐based culturally responsive lens when assessing and intervening with African American couples and families. They focus on the need for therapists to be intentional about and consistent in engaging in self‐exploration and taking the necessary steps to be not just competent but also capable. The final set of best practices detailed relate to assessing and intervening using a strengths‐based approach in a culturally responsive, anti‐racist, and socially attuned fashion. The article concludes with recommendations for couple/family therapists to develop a critical consciousness, engage in anti‐racist practices, and address oppression while advancing healing and liberation, all of which are essential to ensuring the resilience and well‐being of African American couples and families.
An intergenerational study of parental bonding on perceptions of parental and spousal criticism and marital relationship quality in Singapore
Authors: Neoh Michelle Jin Yee , Lieu An An , Perinelli Enrico , Balagtas Jan Paolo Macapinlac , Nah Hilda , Ho Moon‐Ho Ringo , Esposito Gianluca 
Published: September 2023

AbstractCriticism is a form of interpersonal social rejection and destructive conflict behavior which has been associated with poor relationship outcomes in both parent–child and marital relationships. However, the role of the individual's perceptions of parental and spousal criticism in influencing the perceptions of criticism of other members in the family unit has not been examined. This study investigated the associations between parental bonding and perceptions of parental and spousal criticism across generations in Singapore. In all, 134 Singaporean married parent dyads (G2) and one child (G3) of each dyad were recruited. G2 parent participants completed the Perceived Criticism measure for their parents (G1) and spouses, the Parental Bonding Instrument and the Quality of Marriage Index. G3 children participants completed the Perceived Criticism measure for their parents (G2). Path analysis found that G2 perceptions of parental bonding were significant predictors of G2's perceptions of G1 parental criticism, which significantly predicted both G2's perceptions of spousal criticism and G3's perceptions of G2 parental criticism. Perceptions of spousal criticism were also found to predict marital relationship quality in G2 participants. Findings highlight the intergenerational transmission of perceptions of criticism across relationships in the family unit, providing support that parenting practices and communication patterns in one generation can predict those in the next generation in the Singaporean context. Future studies can look to replicate the findings in other cultures and include further investigations into sibling relationships as well.
Effect of resting time on rheological properties of glass bead suspensions: Depletion and bridging force among particles
Authors: Ji Yanliang , Becker Simon , Lu Zichen , Mezhov Alexander , von Klitzing Regine , Wolfram Schmidt , Stephan Dietmar 
Published: September 2023

AbstractThe effect of resting time on the rheological properties of cement suspensions is generally explained by early formed structure and overconsumption of polycarboxylate superplasticizers (PCEs). In this paper, we propose that the influence of resting time on the rheological properties is closely related to size variation of non‐absorbed PCE. To identify this, glass bead suspensions were prepared with various amounts of PCE and ionic solution, and their rheological properties were evaluated at various times. We found that the yield stress increases with time at higher PCE concentrations and higher ionic strength solutions. Adsorbed PCE during resting tends to bridge the particles rather than disperse them. In addition, it was found that hydrodynamic radius of PCE increased with resting time, and depletion forces resulting from non‐absorbed PCE size changes correlate well with the increased yield stress.
Serious immune‐related upper gastrointestinal toxicity of immune checkpoint inhibitors: a multicenter case series
Authors: Bresteau Clément , Bonnet Pauline , Robert Caroline , Mussini Charlotte , Saiag Philippe , Buecher Bruno , Lebbe Celeste , Allez Matthieu , Benamouzig Robert , Hagège Hervé , Bécheur Hakim , Meyer Antoine , Carbonnel Franck 
Published: September 2023

AbstractBackgroundImmune checkpoint inhibitors (ICI) improve the prognosis of many cancers but cause immune‐related adverse events (IrAEs). Limited data are available on upper gastrointestinal (UGI) IrAEs. We describe the clinical characteristics, prognosis, and efficacy of medical therapy in patients with UGI IrAEs.MethodsThis is a retrospective, multicenter cohort study of patients with UGI symptoms and moderate to severe endoscopic UGI lesions, occurring after ICI. Efficacy of induction medical therapy and at the most recent follow‐up was assessed.ResultsForty patients were included; of these, 34 (85%) received anti‐PD(L)1, either alone (n = 24) or combined with anti CTLA‐4 (n = 10). Eighteen patients (45%) had concomitant enterocolitis. All patients had severe endoscopic lesions (erosions, ulcerations, hemorrhage, or necrotic lesions). Three patients who received an inefficient initial medical treatment had a complicated course: One patient died of enterocolitis, one had a pneumomediastinum, and one developed an ulcerated stricture of the pylorus. Thirty‐five patients (88%) were treated with corticosteroids; 28 patients (80%) responded, and 20 (57%) reached clinical remission. Eight patients were treated with infliximab, and six responded (75%). After a median follow‐up of 11 months, 36 patients (90%) were in corticosteroid‐free clinical remission for their UGI symptoms. Endoscopic lesions persisted in 68% of patients.ConclusionsICI cause severe UGI IrAEs, which are associated with enterocolitis in approximately half of the patients. Most patients with UGI IrAEs respond to corticosteroids or infliximab. These data support the recommendation to treat these patients without delay and in the same way as those with enterocolitis.
The olfactory striae: A historical perspective on the inconsistent anatomy of the bulbar projections
Authors: De Cannière Gilles 
Published: September 2023

AbstractCentral olfactory pathways (i.e., projection axons of the mitral and tufted cells), and especially olfactory striae, lack common terminology. This is due to their high degree of intra‐ and interindividual variability, which has been studied in detail over the past century by Beccari, Mutel, Klass, Erhart, and more recently, by Duque Parra et al. These variations led to some confusion about their number and anatomical arrangement. Recent advances in fiber tractography have enabled the precise in vivo visualization of human olfactory striae and the study of their projections. However, these studies require their algorithms to be set up according to the presumed anatomy of the analyzed fibers. A more precise definition of the olfactory striae is therefore needed, not only to allow a better analysis of the results but also to ensure the quality of the data obtained. By studying the various published works on the central olfactory pathways from the first systematic description by Soemmerring to the present, I have traced the different discussions on the olfactory tracts and summarized them here. This review adopts a systematic approach by addressing each stria individually and tracing the historical background of what was known about it in the past, compared to the current knowledge. The chronological and organized approach used provides a better understanding of the anatomy of these essential structures of the olfactory system.
Is constant needle motion during soft tissue filler injections a safer procedure? A theoretical mathematical model for evaluating patient safety
Authors: Gonchar Ivan V. , Alfertshofer Michael , Nikolis Andreas , Hong Wei‐Jin , Biesman Brian , Cotofana Sebastian 
Published: September 2023

AbstractBackgroundThe safety rationale behind the constant needle motion injection technique is based on the assumption that due to the constant needle motion and simultaneous soft tissue filler material administration a smaller amount of product per area may be injected into an artery if an artery within the range of the moving needle is inadvertently entered.ObjectiveTo perform mathematical calculations for determining the probability for causing intra‐arterial product administration when constantly moving the needle during facial aesthetic soft tissue filler injections.MethodsThis study was designed as a theoretical investigation into the probabilities for causing adverse events due to intravascular injection of soft tissue filler material when constantly moving a 27‐G needle during facial soft tissue filler administration.ResultsIt was revealed that with a higher number of conducted injection passes a greater soft tissue area can be covered by the needle. The odds of encountering an artery within the covered soft tissue volume and the odds of injecting any volume greater than zero into the arterial blood stream increases with the number of performed injection passes. This increase is greatest between 1 and 10 performed injection passes.ConclusionThis model demonstrates that the constant needle motion technique increases the probability of encountering an artery within the treatment area and thus increases the odds for intra‐arterial product administration. The constant needle motion technique does not increase safety but rather may increase the odds of causing intra‐arterial product administration with the respective adverse consequences for the patient.
Safety of fluoroless radiofrequency catheter ablation for atrial fibrillation in patients with pre‐existing cardiac implantable electronic device: A single‐center study
Authors: Iqbal Arshad Muhammad , Li Kai Yu , Mahmood Mobasser , Gautam Sandeep 
Published: September 2023

AbstractBackgroundRadiofrequency catheter ablation (RFA) for atrial fibrillation (AF) is being increasingly performed without fluoroscopy. This study aims to determine the safety of fluoroless RFA for patients with pre‐existing cardiac implantable electronic devices (CIED).MethodsThis is a single‐center, single‐operator, retrospective, observational study of 225 consecutive fluoroless RFA procedures for AF from June 1, 2019 to June 1, 2022. All procedures were performed with intracardiac echocardiography (ICE) support. Patients with pre‐existing CIED were extracted from the database. Each CIED was interrogated at the start and end of each procedure and at 30‐day follow‐up. Pre‐ and post‐procedure CIED interrogations were compared for any change in device or lead parameters. Patients were tracked for any subsequent device malfunction.ResultsOut of 225 fluoroless AF ablations, 25 (10.2%) had pre‐existing CIED (14 dual‐chamber pacemakers, three dual‐chamber defibrillators, three single‐chamber defibrillators, one single chamber pacemaker, and four biventricular devices). Mean patient age was 71 ± 6 years. The mean duration of indwelling CIED was 1804 ± 1645 days (range: 78–6267 days). One (4%) patient had lead‐related fibrin on ICE imaging. There was no significant difference in lead(s) threshold, impedance, or sensing post procedure or at 30‐day follow‐up compared to pre procedure. None of the patients required lead revision. There were no intra‐ or post‐op thromboembolic events or subsequent device infection. One patient underwent CIED extraction after 11 months for an unrelated secondary device infection.ConclusionsRadiofrequency catheter ablation for AF can be safely performed without fluoroscopy in patients with pre‐existing CIED.
Effects of interventions on the screening behavior in female first‐degree relatives of breast cancer patients: A systematic review
Authors: Shi Yanyan , Ma Zhuyue , Yao Shanshan , Lu Ningning , Wu Yuqing , Cheng Fang 
Published: September 2023

AbstractBackgroundWomen are more likely to develop breast cancer if their first‐degree relatives (FDRs) have the disease, but they are often unaware of their individual risk and conduct screening behaviors.ObjectiveThis study aimed to evaluate the effectiveness of interventions in increasing breast self‐examination, clinical breast examination, and mammography rates in FDRs of breast cancer patients.MethodsWe selected randomized clinical trials and quasi‐experimental studies in eight databases. Interventions in each study were categorized as “promising”, or “non‐promising” according to whether they led to a positive change in screening behaviors. Interventions were also coded using the Behavioral Change Techniques (BCTs) Taxonomy and a promise ratio calculated for each. BCTs with a promise ratio ≥2 was classified as “promising”.ResultsThirteen studies with 21 different BCTs were included. The most frequent BCTs were “Prompts/cues”, “Credible source”, and “Instructions on how to perform the behavior”. Seven BCTs had a promise ratio of ≥2 and the four most promising were “Information about health consequences” (promise ratio = 6), “Problem solving” (promise ratio = 4), “Demonstration of the behavior” (promise ratio = 4), and “Adding objects to the environment” (promise ratio = 4).ConclusionsThis review indicated an overall weak use of theory, and an insufficient description of several interventions to support the assessment of how specific BCTs were activated.
Applying Natural Ventilation for Commercial Buildings With Atrium: Indoor Environment Prediction and Outdoor Pollutant Impact
Authors: Zhai Zhiqiang (John) , Baum Jack , Griego Danielle 
Published: September 2023

Abstract
The use of natural ventilation for commercial buildings becomes ever attractive due to the potential for economic savings and increased occupant satisfaction. However, it has proven to be particularly challenging to predict the indoor air temperature and airflow distribution from natural ventilation in more complex building geometries such as those with an atrium. This study used the energy-simulation-coupled computational fluid dynamics (CFD) method to predict the indoor temperatures of a typical multi-story, open-floorplan office building with a central atrium. The prediction accuracy using CFD was slightly improved for the periods with extreme outdoor conditions, where large temperature disparities often occur between simulation and experiment. For the tested cases, adjustment of window opening sizes seems to have marginal impacts on the simulation results. This paper further explores the impacts of outdoor gas-phase pollutants on indoor air quality of such a naturally ventilated commercial building with an atrium. A few architectural features such as window blockers and double skin façade (DSF) designs were numerically investigated for their performance to lower the indoor pollution levels while still maintaining adequate building ventilation rates. The results reveal that the features affecting the wind patterns around and above the building have a strong influence on the contamination rates on each floor of the building. DSF can not only reduce indoor pollution levels but also reduce the ventilation rate. When a pollutant source is not close to the building, a conventional central atrium design is preferred for better ventilation rates.
Complete coding sequence of Tembusu virus isolated from geese in Taiwan in 2020
Authors: Chen Yen-Ping , Huang Chih-Wei , Lee Fan 
Published: September 2023

ABSTRACT
We reported the complete coding sequence of a Tembusu virus (TMUV) isolated from sick geese in Taiwan in 2020. The nucleotide sequence of the 20120008 isolate was most closely related to the strain TP1906 isolated from mosquitoes in Taiwan and clustered within a subgroup of Cluster 4 of the Tembusu virus.
Quantifying unmet need in General Practice: a retrospective cohort study of administrative data
Authors: McConnachie Alex , Ellis David A , Wilson Philip , McQueenie Ross , Williamson Andrea E 
Published: September 2023

ObjectivesTo assess whether patients attending general practices (GPs) in socioeconomically (SE) deprived areas receive the same amount of care, compared with similar patients (based on age, sex and level of morbidity) attending GPs in less deprived areas. If not, to quantify the additional resource that would be required by GPs in deprived areas to achieve parity.DesignRetrospective cohort study.Setting150 GPs in Scotland, UK, divided into two groups: 80 practices in Scottish Index of Multiple Deprivation (SIMD) deciles 1–5 (more SE deprived); 70 practices in SIMD deciles 6–10 (less SE deprived).Patients437 590 patients registered with a more SE deprived GP, and 333 994 patients registered with a less SE deprived GP, for the whole study period (2013–2016), who made at least one appointment.OutcomesThe number of contacts and total contact time between patients and clinical staff.ResultsPatients in more SE deprived areas had slightly more discrete contacts over 3 years (11.8 vs 11.4), but each patient had marginally less contact time (146.1 vs 149.5 min). Stratified by sex and age, differences were also small. Stratified by the number of long-term conditions (LTCs), practices in more SE deprived areas delivered significantly less contact time than practices in less SE deprived areas. Over 3 years, 8 fewer minutes for patients with no LTCs, and 24, 27, 38 and 28 fewer minutes for patients with 1, 2, 3–4 or 5+LTCs, respectively.ConclusionIf GPs in more SE deprived areas were to give an equal amount of direct contact time to patients with the same level of need served by GPs in less SE deprived areas, this would require a 14% increase in patient contact time. This represents a significant unmet need, supporting the case for redistribution of resources to tackle the inverse care law.