bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental analysis of the effect of natural fibers and SiC filler on the thermal behavior of green biocomposites
Authors: Melati Asih , Settar Abdelhakim , Chetehouna Khaled , Okur Nazan , Berkalp Omer Berk 
Published: July 2023

AbstractThe present work deals with the thermal behavior investigation of new biocomposite materials intended to be used for process engineering applications. Particular attention is given to the thermal degradation of such materials. Thermal characterization at different scales is performed using thermogravimetric analysis (TGA) and cone calorimeter experiments. The main purpose is to compare the thermal behavior of new bamboo‐based and banana‐based Green Biocomposites (GBCs). An intumescent fire retardant (IFR) coating, which is a mixture of APP and boric acid was applied on the GBC sample surface to study the flame retardancy. The GBC samples was first manufactured using a vacuum resin transfer molding. TGA results showed that bamboo‐based (BM‐GBC) and banana‐based (Bn‐GBC) materials exhibits similar thermal degradation pattern. While cone calorimeter experiments revealed that BM‐GBC outperforms than Bn‐GBC. The IFR coating improved the flame retardancy of both GBCs by reducing the heat release rate as well as a noticeable reduction in terms of smoke emission. Finally, to improve the thermal stability of Bn‐GBC material, SiC powder is added as a filler. The IFR coating and SiC powder addition promotes considerably the thermal behavior of Bn‐GBC materials.
Two New Amides from Physochlainae Radix
Authors: Tan Jin‐Yan , Li Jian‐Li , Li Pei , Zhang Lu , Cheng Yan‐Gang , Wang Yan , Ma Xiao‐Nan , Hao Xu‐Liang , Wang Ying‐Li 
Published: July 2023

AbstractIn this article, two undescribed amides (1–2) with an unusual (2‐formyl‐5‐hydroxymethyl)pyrroyl‐butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HR‐ESI‐MS, coupling with spectroscopic data comparisons were used to determine structures. Anti‐inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS‐induced RAW 264.7 cells, with IC50 values of 17.52±1.68 μM and 20.37±2.42 μM, respectively.
Fire influences ant diversity by modifying vegetation structure in an Australian tropical savanna
Authors: Brassard François , Pettit Magen J. , Murphy Brett P. , Andersen Alan N. 
Published: July 2023

AbstractFire is a dominant ecological force shaping many faunal communities globally. Fire affects fauna either directly, such as by killing individuals, or indirectly, such as by modifying vegetation structure. Vegetation structure itself also modulates fire frequency and intensity. As such, faunal responses to fire need to be seen through the lens of variable fire activity and vegetation structure. Here, we incorporate information on fire activity and vegetation structure to enhance an understanding of the response of ants to long‐term (17‐year) experimental fire treatments in an extremely fire‐prone tropical savanna in northern Australia. Previous analysis revealed limited divergence in ant communities after 5 years of experimental fire treatment. Hence, we first investigated the extent to which ant communities diverged over a subsequent 12 years of treatment. We then assessed the relative contribution of fire treatment, cumulative fire intensity (fire activity), and woody cover to responses of ant species frequency of occurrence, richness, and composition. We found that, even after 17 years, fire treatments explained little variation in any ant response variable. In contrast, woody cover was a strong predictor for all of them, while fire activity was a moderate predictor for abundance and richness. Ant species occurrence and richness increased in open habitats receiving higher levels of fire activity, compared with plots with higher vegetation cover experiencing low (or no) fire activity. Moreover, species composition differed between plots with high and low vegetation cover. Our findings provide experimental support to the principle that the effects of fire on fauna are primarily indirect, via its effect on vegetation structure. Furthermore, our results show that a “uniform” fire regime does not have uniform impacts on the ant fauna, because of variability imposed by interactions between vegetation structure and fire activity. This helps to explain why there is often a weak relationship between pyrodiversity and biodiversity, and it lessens the need for active management of pyrodiversity to maintain biodiversity.
Population Pharmacokinetic Modeling and Stochastic Simulations to Support Pediatric Dose Selection of Pimavanserin
Authors: Darwish Mona , Bugarski‐Kirola Dragana , Jaworowicz David , Owen Joel , Al Qaraghuli Farah , Barry Alida , DeKarske Daryl 
Published: July 2023

AbstractPimavanserin is a selective serotonin‐modulating agent with inverse agonist/antagonist activity at the 5‐hydroxytryptamine2A (5‐HT2A) receptor. The safety and efficacy of pimavanserin 34 mg once daily were studied in adults with hallucinations and delusions associated with Parkinson's disease psychosis and other neuropsychiatric conditions. This analysis used model‐based simulations of pimavanserin steady‐state exposures to identify a dose that generated pediatric exposures comparable with adult exposures achieved with 34 mg pimavanserin. A population pharmacokinetics model was developed using pooled plasma drug concentration (ie, actual) data from 13 clinical studies, including a phase 1 study of adolescent pediatric patients (aged 13‐17 years) with various psychiatric conditions. Stochastic simulations were performed to predict exposures in a virtual (ie, simulated) group of pediatric patients (aged 5‐17 years). Steady‐state measures of the area under the plasma concentration–time curve (AUC) and maximum drug concentration (Cmax) were simulated for relevant age and weight stratifications and compared with simulated exposures in adults (aged 18‐49 years). The simulated mean AUC ranged from 47.41 to 54.73 ng d/mL and the mean Cmax ranged from 41.13 to 50.07 ng/mL in adults receiving pimavanserin 34 mg. The simulated mean (SD) Cmax of 56.54 (24.58) ng/mL with pimavanserin 34 mg in patients aged 10‐17 years was similar to that in adults. Pimavanserin 20 mg yielded a mean (SD) Cmax of 45.30 (21.31) ng/mL in patients aged 5‐9 years and 49.18 (22.91) ng/mL in the pediatric patient weight group of 14‐25 kg, which are values close to the Cmax in adults treated with 34 mg. Pimavanserin 20 and 34 mg in pediatric patients aged 5‐9 and 10‐17 years, respectively, yielded exposures similar to daily pimavanserin 34 mg in adults aged 18‐49 years.
The cancer survivor—Manager dyad during the return‐to‐work process: An introduction with theoretical, conceptual, and methodological considerations
Authors: Greidanus Michiel A. , Porro Bertrand 
Published: July 2023

AbstractObjectiveThere is a need for tailored interventions aimed at promoting the sustainable return to work (RTW) of cancer survivors. As managers have a primary role in supporting cancer survivors to return to work, a better understanding of the “cancer survivor‐manager” dyadic process is much needed. The aim of this paper is to introduce the cancer survivor‐manager dyad in the context of RTW of cancer survivors, and to inform future studies by presenting theoretical, conceptual, and methodological considerations.ConclusionsDifferent theoretical, conceptual, and methodological aspects are addressed that open new perspectives concerning the cancer survivor‐manager dyad. Among the theoretical and conceptual aspects, we highlight the interest of developing dyadic coping models specific to the cancer survivor‐manager dyad. This would allow the conceptualization of their interpersonal dynamics and to frame interventions aimed at supporting cancer survivors and managers. In addition, we encourage to study in more detail the quality of the relationship between the cancer survivor and manager, including its impact on work‐related outcomes of the cancer survivor. Methodologically, the actor‐partner interdependence model could be relevant to identify any interdependence in the cancer survivor‐manager dyad. We also recommend using longitudinal and prospective studies to investigate the cancer survivor‐manager dyad, as these studies are well suited to identify evolutive and dynamic aspects of the cancer survivor‐manager dyad. Lastly, we propose a recruitment strategy of the dyad by involving a trustworthy third party, to respect the ethical framework, and the privacy and voluntary choice of cancer survivors.
Exploring the Charge Storage Dynamics in Donor–Acceptor Covalent Organic Frameworks Based Supercapacitors by Employing Ionic Liquid Electrolyte
Authors: Chatterjee Amrita , Sun Jiamin , Rawat Kuber Singh , Van Speybroeck Veronique , Van Der Voort Pascal 
Published: July 2023

AbstractTwo donor–acceptor type tetrathiafulvalene (TTF)‐based covalent organic frameworks (COFs) are investigated as electrodes for symmetric supercapacitors in different electrolytes, to understand the charge storage and dynamics in 2D COFs. Till‐date, most COFs are investigated as Faradic redox pseudocapacitors in aqueous electrolytes. For the first time, it is tried to enhance the electrochemical performance and stability of pristine COF‐based supercapacitors by operating them in the non‐Faradaic electrochemically double layer capacitance region. It is found that the charge storage mechanism of ionic liquid (IL) electrolyte based supercapacitors is dependent on the micropore size and surface charge density of the donor–acceptor COFs. The surface charge density alters due to the different electron acceptor building blocks, which in turn influences the dense packing of the IL near its pore. The micropores induce pore confinement of IL in the COFs by partial breaking of coulomb ordering and rearranging it. The combination of these two factors enhance the charge storage in the highly microporous COFs. The density functional theory calculations support the same. At 1 A g−1, TTF‐porphyrin COF provides capacitance of 42, 70, and 130 F g−1 in aqueous, organic, and IL electrolyte respectively. TTF‐diamine COF shows a similar trend with 100 F g−1 capacitance in IL.
Crystal structure and properties of the magnetically frustrated B‐site ordered Sr2CaOsO6 double perovskite
Authors: Thakur Gohil S. , Schnelle Walter , Jansen Martin 
Published: July 2023

AbstractThe B‐site ordered double perovskite Sr2CaOsO6 has been synthesized by a solid‐state reaction under ambient pressure. Sr2CaOsO6 is isostructural to Sr2NaOsO6 and Sr2CaReO6, thus crystallizes in the monoclinic space group P21/n, in contrast to cubic lattice symmetry reported in an earlier publication. The compound remains paramagnetic down to a temperature of 2 K. This finding is of relevance with regard to the high‐temperature ferromagnetism observed in Sr3OsO6 thin films and may find interest in view of possible exotic ground states in frustrated magnetic systems.
Symmetry group at future null infinity II: Vector theory
Authors: Liu Wen-Bin , Long Jiang 
Published: July 2023

Abstract
In this paper, we reduce the electromagnetic theory to future null infinity and obtain a vector theory at the boundary. We compute the Poincaré flux operators which could be generalized. We quantize the vector theory, and impose normal order on the extended flux operators. It is shown that these flux operators generate the supertranslation and superrotation. When work out the commutators of these operators, we find that a generalized electromagnetic duality operator should be included as the generators to form a closed symmetry algebra.
Bootstrapping Witten diagrams via differential representation in Mellin space
Authors: Li Yue-Zhou , Mei Jiajie 
Published: July 2023

Abstract
We explore the use of the differential representation of AdS amplitudes to compute Witten diagrams. The differential representation expresses AdS amplitudes in terms of conformal generators acting on contact Witten diagrams, which allows us to construct differential equations for Witten diagrams. These differential equations can then be transformed into difference equations in Mellin space, which can be solved recursively. Using this method, we efficiently re-computed scalar four-point amplitudes and obtained new results for scalar six-point amplitudes mediated by gluons and scalars, as well as two examples of scalar eight-point amplitudes from gluon exchange.
Global continua of solutions to the Lugiato–Lefever model for frequency combs obtained by two-mode pumping
Authors: Gasmi Elias , Jahnke Tobias , Kirn Michael , Reichel Wolfgang 
Published: July 2023

AbstractWe consider Kerr frequency combs in a dual-pumped microresonator as time-periodic and spatially $$2\pi $$

2
π

-periodic traveling wave solutions of a variant of the Lugiato–Lefever equation, which is a damped, detuned and driven nonlinear Schrödinger equation given by $$\textrm{i}a_\tau =(\zeta -\textrm{i})a-d a_{x x}-|a|^2a+\textrm{i}f_0+\textrm{i}f_1\textrm{e}^{\textrm{i}(k_1 x-\nu _1 \tau )}$$

i

a
τ

=

(
ζ
-
i
)

a
-
d

a

xx

-

|
a
|

2

a
+
i

f
0

+
i

f
1

e

i
(

k
1

x
-

ν
1

τ
)

. The main new feature of the problem is the specific form of the source term $$f_0+f_1\textrm{e}^{\textrm{i}(k_1 x-\nu _1 \tau )}$$

f
0

+

f
1

e

i
(

k
1

x
-

ν
1

τ
)

which describes the simultaneous pumping of two different modes with mode indices $$k_0=0$$

k
0

=
0

and $$k_1\in \mathbb {N}$$

k
1

∈
N

. We prove existence and uniqueness theorems for these traveling waves based on a-priori bounds and fixed point theorems. Moreover, by using the implicit function theorem and bifurcation theory, we show how non-degenerate solutions from the 1-mode case, i.e., $$f_1=0$$

f
1

=
0

, can be continued into the range $$f_1\not =0$$

f
1

≠
0

. Our analytical findings apply both for anomalous ($$d>0$$

d
>
0

) and normal ($$d<0$$

d
<
0

) dispersion, and they are illustrated by numerical simulations.
Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany
Authors: Trabert Milan , Seifert Roland 
Published: July 2023

AbstractDemographic change is taking place in the population of western industrialized countries, and the population is aging constantly. As a result, the mortality rate of patients due to dementia is rising steadily. To counteract this, the relevance of neuroprotective agents is increasing. Preparations from the medicinal tree species Ginkgo biloba (“gingko”) are becoming increasingly popular. In this study, 63 ginkgo preparations marketed in Germany were analyzed. The following data were collected from the package inserts of the preparations: Country of manufacture, approval as a drug, compliance to target values of flavone glycosides, compliance to target values of terpene lactones, compliance to target values of ginkgolic acids, dosage per unit in milligrams (mg), duration of use, interactions with other drugs, contraindications, adverse effects and daily defined dose costs. In the next step, these data were compared in the following form: Total preparations versus preparations with drug approval versus dietary supplements. Almost without exception, the results indicate a pharmaceutical reliability of the preparations with drug approval and a dubious reliability of the preparations marketed as dietary supplements. Thus, ginkgo preparations marketed as dietary supplements appear to have an economic rather than a medical focus. We discuss the evidence of efficacy, and other criteria mentioned above, to evaluate the adequacy of the costs for the statutory health insurance that pay for preparations with drug approval in Germany. From the analysis of our results it is very doubtful that ginkgo biloba extract preparations of the food industry have any health benefit. It must be evaluated whether prohibition of selling ginkgo biloba extract as a dietary supplement is an option.
Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons
Authors: Pissas Karolos-Philippos , Schilling Maria , Tian Yuemin , Gründer Stefan 
Published: July 2023

AbstractAcid-sensing ion channels (ASICs) are Na+ channels that are almost ubiquitously expressed in neurons of the brain. Functional ASIC1a is also expressed in glioblastoma stem cells, where it might sense the acidic tumor microenvironment. Prolonged acidosis induces cell death in neurons and reduces tumor sphere formation in glioblastoma via activation of ASIC1a. It is currently unknown whether ASICs are expressed and involved in acid-induced cell death in other types of brain tumors. In this study, we investigated ASICs in medulloblastoma, using two established cell lines, DAOY and UW228, as in vitro models. In addition, we characterized ASICs in the most numerous neuron of the brain, the cerebellar granule cell, which shares the progenitor cell with some forms of medulloblastoma. We report compelling evidence using RT-qPCR, western blot and whole-cell patch clamp that DAOY and cerebellar granule cells, but not UW228 cells, functionally express homomeric ASIC1a. Additionally, Ca2+-imaging revealed that extracellular acidification elevated intracellular Ca2+-levels in DAOY cells independently of ASICs. Finally, we show that overexpression of RIPK3, a key component of the necroptosis pathway, renders DAOY cells susceptible to acid-induced cell death via activation of ASIC1a. Our data support the idea that ASIC1a is an important acid sensor in brain tumors and that its activation has potential to induce cell death in tumor cells.
A nomogram incorporating Ki67 to predict survival of acral melanoma
Authors: Du Yu , Li Caili , Mao Lili , Wei Xiaoting , Bai Xue , Chi Zhihong , Cui Chuanliang , Sheng Xinan , Lian Bin , Tang Bixia , Wang Xuan , Yan Xieqiao , Li Siming , Zhou Li , Guo Jun , Si Lu 
Published: July 2023

Abstract
Background
The proliferation marker Ki67 is associated with the progression and prognosis of melanoma. However, its prognostic impact on acral melanoma (AM) remains unclear.

Methods
A total of 314 AM patients were enrolled from a cohort of 5758 patients with melanoma at Peking University Cancer Hospital between 2006 and 2018. The patients were divided into Ki67 high- and low-expressing groups using a cut-off value of 30%. The associations between Ki67 and clinicopathologic characteristics as well as survival were analyzed. Cox proportional regression analysis was used to establish a nomogram to predict the survival probabilities of AM.

Results
Among 314 patients, the Ki67-high group (Ki67 ≥ 30%) included 49.4% of patients at diagnosis. Patients in the Ki67-high group had lower median melanoma-specific survival (MSS) than those in the Ki67-low group (60.7 months vs. not reached, p < 0.001). In multivariate analyses, Ki67, lymph node metastasis and primary site were independent prognostic factors for MSS. The nomogram showed that Ki67 had the fourth greatest impact on survival, following Breslow thickness, lymph node metastasis and primary site. The C-index of the nomogram was 0.765 and 0.758 in the training and validation cohort, respectively. Area under the curve values were both near 0.8 in the training and validation cohorts. Net reclassification improvement and integrated discrimination improvement demonstrated that the predictive nomogram performed better than the traditional AJCC staging system.

Conclusion
Ki67 expression is an independent prognostic factor for MSS in AM. A predictive model incorporating Ki67 and clinical factors was constructed to predict the prognosis of AM.
Professional development of adult educators: A European perspective
Authors: Ioannou Nicoletta 
Published: July 2023

AbstractThis article provides an overview of major dimensions of the professional development of adult educators identified in European policy documents, relevant reports and research. The author reviews the relevant policy visions of the past two decades, aiming to determine the extent to which professional development of adult educators is visible in European policy documents, how it is conceptualised and under which terms it is discussed. The author argues that adult educators play an essential role in adult education and society in general, are an important factor for securing quality in the sector, and are considered to be a critical pillar of adult education. To perform this role well, they require specialised, targeted and systematic professional development programmes in a changing environment which affects both their learners’ and their own position as educators. However, the analysis of the policy documents shows that despite a consensus about the importance of quality adult education, over the past two decades little attention has been given to the initial training and continuous professional development of adult educators in practical terms. Due to a lack of opportunities, their professional development seems weak and still faces many challenges.
‘It Doesn’t Give Off the Gambling Vibes … It Just Feels Like a Part of the Game’: Adolescents’ Experiences and Perceptions of Simulated Gambling While Growing Up
Authors: Hing Nerilee , Lole Lisa , Thorne Hannah , Sproston Kerry , Hodge Nicole , Rockloff Matthew 
Published: July 2023

AbstractThis study explores the lived experience of simulated gambling as young people grow up. Qualitative research with 89 Australians aged 12–17 years explored their chronological experiences of simulated gambling and monetary gambling. Reflexive thematic narrative analysis identified common and contrasting themes amongst at-risk/problem gambling, non-problem gambling, and non-gambling participants. As young people grow up, they engage in simulated gambling more frequently, in more diverse settings, and on activities more akin to monetary gambling. Their motivations expand from valuing virtual prizes, to also valuing social benefits and opportunities to learn new gambling games, compete against other players and demonstrate skill. Simulated gambling becomes highly normalised from childhood and before young people realise its potential for gaming and gambling harm. Behavioural associations between simulated gambling and harmful gaming were evident, but those between simulated gambling and harmful monetary gambling were less clear. Restricting youth access to simulated gambling would help protect them from harm.
Mycoparasitism of Fomitopsis pinicola (Sw.) P. Karst. by Antrodiella citrinella Niemelä & Ryvarden
Authors: Wieners Max , Bässler Claus , Scholler Markus 
Published: July 2023

AbstractAntrodiellaspecies (Agaricomycotina,Polyporales) are often growing on or near to the living, dead, or dying fruitbodies of pioneer wood-inhabiting fungi.Antrodiella citrinellaalways occurs on wood that previously has been decayed by the polyporeFomitopsis pinicola. However, the underlying mechanism remained unclear. Based on field observations, it has been assumed that the succeeding species is not only a highly competitive wood decomposer but also a mycoparasite feeding on the preceding species. To investigate the interaction betweenA. citrinellaand the putative hostF. pinicola, the species were grown in dual cultures at different temperatures (5–25 °C). The interaction tests were complemented with qualitative enzymatic tests for both species and microscopic examination of the interaction zone. In the dual cultures,A. citrinellareplacedF. pinicolaonly at low temperature (5 °C); at higher temperatures (25 °C), it was vice versa. Light microscopy revealed preferential growth ofA. citrinellatowardF. pinicola, hyphal contact, and finally death ofF. pinicolahyphae. Enzymatic tests showed thatA. citrinellais capable to degrade extracellular proteins, chitin, cellulose, and lignin. We interpret the interaction as mycoparasitism, as we suggest thatA. citrinellais capable to recognize, kill, and feed fromF. pinicola, beside its ability to degrade woody substrates. The results are discussed in an ecological context.