bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor Analysis of Impulsivity in Gaming Disorder and Internet Gaming Disorder
Authors: Raybould Jodie N. , Tunney Richard J. 
Published: September 2023

Abstract

Background: Research suggests that a two-factor model impulsivity predicts substance addictions and use and Gambling Disorder. We aimed to determine whether a similar factor structure was present for Gaming Disorder (GD) and Internet Gaming Disorder (IGD).
Methods: Secondary data analysis was conducted on survey responses from 372 participants who had completed a series of questions on facets of impulsivity and level of involvement in gaming. Participants were sampled from gaming forums and an online recruitment website. Factor analysis was conducted on the measures of trait impulsivity, and the identified factors were then analyzed against measures of Gaming Disorder and Internet Gaming Disorder.
Results: The results suggested a five-factor model of impulsivity, with gaming being related to all five factors. Interestingly, a two-factor model of Urgency (Positive Urgency, Negative Urgency, Delay Discounting) and Inhibitory Control(False Button Presses on Go/No-Go Tasks) predicted symptom counts above the clinical cut-off for IGD. In addition, Urgency was related to symptom counts above 7/9 criteria for IGD, as well as symptom counts above the suggested clinical cut-off for GD.
Conclusions: This two-factor model of impulsivity is similar to those found in established addiction disorders, in that one factor appears to predict more problematic involvement than the other. However, the results indicate that Urgency predicts higher symptom counts than Inhibitory Control. This contrasts with previous findings on substance use and gambling, where Inhibitory Control was the factor predicting problematic use. However, there was evidence to suggest that gaming is similar to alcohol consumption, where socially acceptable, “healthy,” use is related to impulsivity at some level, but Urgencyis key in the transition from recreational to disordered behavior.
Research on Ecological Restoration of Landscape Environment Based on the Perspective of Regional Environmental Culture
Authors: Zhang Xiaorui 
Published: September 2023

Abstract
With the rapid development of economy, the rapid growth of population and the accelerating pace of urbanization, water pollution is becoming more and more serious. Most urban parks and lakes are polluted and seriously eutrophic, losing their due landscape ecological value. This study takes lake A in a city as an example, based on the perspective of geographical environment and relying on the ecological restoration project of Lake A. This paper analyzes the changes of physical and chemical indexes and biological indexes of water quality with time series through the whole process tracking and monitoring of ecological restoration project; Through the evaluation of eutrophication of lake A, the test indexes and sensitivity of ecological restoration effect are studied. Combined with the current eutrophication evaluation system, new water quality test parameters are proposed to diagnose and evaluate the water quality of shallow eutrophic lakes after ecological restoration. The results show that through the implementation of ecological restoration project, the water quality of lake A has been well improved and basically stabilized at the class IV standard of surface water; The dominant species of phytoplankton community changed from large-scale colony algae to small-scale individual algae, the algal biomass was well controlled and the eutrophication status was improved.
Concentration of toxic and essential elements in livers of birds of various foraging guilds collected during the autumn migration period in Poland
Authors: Ignacy Kitowski , Rafał Łopucki , Dariusz Wiącek , Grzegorz Pitucha , Sujak Agnieszka , Jakubas Dariusz 
Published: September 2023

Abstract
During migration, birds explore various habitats at stopover sites that differ in food resources and contamination levels. In this study, hepatic concentrations of 21 elements in 11 species of birds, representing various foraging guilds (omnivores, piscivores, molluscivores) and migration modes (migratory, sedentary), were analyzed. The samples were collected during the autumn migration period in Poland. The concentrations of elements determined in this study exhibited high inter-species variability, reflecting the diversity of food resources used by specific bird groups and their contamination levels. Many of the investigated individuals from different species showed exceeded levels of subclinical toxicity and moderate clinical poisoning due to Cd and Hg. The data collected confirmed the limited ability of As to enter ecosystem pathways. This study suggests that measuring hepatic elemental concentrations can help detect environmental contamination at stopover sites used during migration and identify the key contaminants that can impact avian health during this period. The presented results contribute significantly to understanding the year-round exposure of migratory birds to environmental contamination.
A meta-analysis on genetic susceptibility to chronic otitis media
Authors: Cao Jingwen , Yang Zixuan , Qu Gaoya , Zhong Cuiping , Liu wei 
Published: September 2023

Abstract
Chronic otitis media (COM) is known for its high prevalence (approximately 80% in children) and is thought to share common genetic risk factors, which means that there is a need to systematically study susceptibility genes associated with COM. We screened studies associated with COM genes between January 2019 and February 2023. Ten papers with 932 patients meeting the criteria were finally included, and a case-control analysis of the relationship between gene polymorphisms and COM susceptibility was performed using RevMan 5.3 software. The literature on the relationship between polymorphisms in genes related to susceptibility to chronic otitis media and chronic otitis media was tested for consistency and data merged according to different genes, and some genes were found to be polymorphic. Attitude, VEGF and Nrf2 were correlated with chronic otitis media (P < 0.05). Gene polymorphism and chronic otitis media may be related to the nationality of patients; TNF- α, IL-10, VEGF and Nrf2 may promote the formation of granulation tissue during the inflammatory phase and participate in the repair process of chronic inflammation; high expression of Nrf2 in the middle ear tissue of chronic otitis media is related to the pathogenesis of chronic otitis media.
Developing a GC-EI-MS/MS Method for Quantifying Warfarin and Five Hydroxylated Metabolites Generated by the Fenton Reaction.
Authors: von Törne Wipert Jannik , Klyk-Seitz Urszula-Anna , Piechotta Christian 
Published: September 2023

Abstract
As a drug and rodenticide, warfarin is used globally. Extensive research has shown that warfarin and other rodenticides are recoverable in the environment and food chain (Fernandez, Santos, Cancela, Laize, & Gavaia, 2014; Gomez-Canela, Barata, & Lacorte, 2014; Nakayama, Morita, Ikenaka, Mizukawa, & Ishizuka, 2019; Rattner, Lazarus, Elliott, Shore, & van den Brink, 2014; Saito-Shida, Nemoto, Matsuda, & Akiyama, 2016; Waddell, Poppenga, & Drobatz, 2013). Current methods for their analytical determination focus on the target component rather than on metabolites or transformation products. Warfarin's phase 1 metabolism is extensively studied. Mono-hydroxylated metabolites are primarily formed (Watanabe et al., 2015; Wong & Davis, 1989). In this study, the use of the Fenton reaction aimed to generate mono-hydroxylated transformation products in the laboratory. A GC-MS/MS method was designed to quantify the expected derivatized metabolites by multiple reaction monitoring. Warfarin, 4'-, 5-, 6-, 7-, and 8-hydroxy warfarin, and isotopically labeled reference compounds were used for this approach. The method has a linear working range of 30 to 1800 pg/µL. Detection limits obtained range between 18.7 to 67.0 pg/µL. In addition, a C18-SPE step was used to enrich the analytes, and the recovery for each compound was calculated. The derivatization yield of warfarin for in-liner derivatization with m-TFPTAH was determined as well. The method was used successfully to show that 4'-O-Me-WAR is preferentially formed under the given experimental conditions. Furthermore, the Fenton reaction has generated all preselected mono-hydroxylated transformation products. The maximum intensities of all target analytes were reached at around 4 minutes and immediately decreased after that. The applicability of GC-MS for determining known metabolites of warfarin was demonstrated. With SPE clean-up, the method is also suitable for detecting metabolites in more complex matrices, for example, environmental water samples in the future.
Impact of metabolic syndrome on clinical characteristics and one-year outcomes of patients undergoing primary percutaneous coronary intervention
Authors: Geraiely Babak , Shahmohamadi Elnaz , Nejad Mohammad Javad Zare , Barzegary Alireza , Larti Farnoosh , Zeinali Ali Mohammad Haji 
Published: September 2023

Abstract
Background
Metabolic syndrome (MetS) is a set of symptoms, including insulin resistance, high blood sugar, and abdominal obesity, that increases the risk of cardiovascular diseases. This syndrome is prevalent in acute coronary syndrome (ACS), comprising patients with acute myocardial infarction (AMI). This study evaluated the prognosis of AMI patients who underwent primary PCI in two groups with and without MetS.
Methods
This retrospective study was performed on ST-segment elevation myocardial infarction (STEMI) patients referred to the emergency department of Tehran Heart Center from 2012 to 2020 who underwent primary PCI. Patients were divided into MetS and non-MetS according to International Diabetes Federation (IDF) criteria. Clinical and laboratory characteristics were compared between the two groups.
Results
3103 patients were included, and 2144 patients (69%) had MetS. The mean age of both groups was approximately 62 years. In both groups, the majority were men. Sixty-six in-hospital deaths occurred, with no significant difference regarding the presence of MetS. One hundred fifty-two deaths happened during the one-year follow-up, without a significant difference between the two groups. Four hundred twenty-one MACE were observed in one year, which was not significantly different between patients with and without MetS. Analysis of patients with a BMI less than 25 kg/m2 revealed significantly higher MACE in MetS compared to the non-MetS group.
Conclusion
In-hospital mortality, one-year death, and one-year MACE were not associated with MetS in this study.
Self-rated health and its determinants in patients with hypertension in Isfahan in 2019
Authors: Mansouri Asieh , Khosravi Alireza , Mohammadifard Noushin , Nouri Fatemeh , Jozan Mahnaz , Tabatabaei Ghazaal Alavi , Salehidoost Rezvan , Rafie Hamed 
Published: September 2023

Abstract
Background and Objectives:
This article examines the self-rated health (SRH) and its determinants in Iranian patients with hypertension (HTN). SRH is a measure of satisfaction with social, mental, and physical health and has been widely used in public health research. The study aims to identify the factors that influence SRH among hypertensive patients in Iran.
Material and Methods
The data were obtained from a project evaluating the impact of hypertension guidelines on patient care. A total of 886 patients with essential HTN were included in the study. The patients' demographic and clinical characteristics, including education, income, comorbidities, and HTN control, were assessed.
Results
The results showed that higher education level and income were associated with better SRH. Patients without diabetes had higher SRH scores.
Conclusion
This study highlights the importance of socioeconomic factors and comorbidities in determining SRH among hypertensive patients in Iran. The findings can contribute to the development of interventions and strategies for improving HTN treatment and prevention in Middle Eastern countries.
Does timing of sexual debut following menarche among female youth in Uganda Matter? A discrete time analysis.
Authors: Nsimbe Dick , Lwanga Charles , Namawejje Hellen 
Published: September 2023

Abstract

Background
The burden of early sexual engagement among young people is enormous. It raises the risk of sexually transmitted infections(STIs), such as HIV/AIDS, unintended pregnancy, unsafe abortion, premature childbirth, and psychosocial issues. The aim of this paper was to estimate the timing of sexual debut and examine the factors influencing the timing of first sexual intercourse following menarche among female youth aged between 15 and 24 in Uganda.
Method
Self-reported data were extracted from the 2016 Uganda Demographic and Health Survey (UDHS), with a sub-sample of 7964 female youth from the individual woman file. Kaplan-Meier survival curves, decrement life-table analysis, and the discrete-time logit model were used to examine the timing of sexual debut and associated factors.
Results
About 67% of the female youth had experienced first sexual initiation. Overall, the meantime to sexual debut was 4.4 years and the median time was 4.3 years, and all the female youth had experienced first sexual initiation by the end of the twelfth year following menarche. Significant factors found to influence the timing of sexual initiation include having higher education level (OR = 0.724: 95% CI = 0.59–0.89; p = 0.003), residing in the Northern region (OR = 0.877:95% CI = 0.79–0.97, p = 0.012), being employed (OR = 1.085: 95% CI = 1.01–1.16; p = 0.021), and being literate (OR = 1.155; 95% CI = 1.07–1.25; p < 0.001).
Conclusions
These findings are expected to be central in the bid to delay first sexual intercourse. Also they shed light on some of the factors associated with the timing of sexual debut which may be addressed at community level for non-school going youth and in schools, as school based prevention sexual and reproductive health programs.
Assessment of Preoperative Planning and Intraoperative Accuracy of the AIKNEE System for Total Knee Arthroplasty
Authors: Lan Saijiao , Li Jian 
Published: September 2023

Abstract

Background
The aim of this retrospective study was to evaluate the effectiveness and accuracy of the AIKNEE system in preoperative planning and intraoperative alignment for total knee arthroplasty (TKA).
Methods
A total of 64 patients were planned preoperatively by the AIKNEE system, including the measurement of mechanical femorotibial angle (mFTA), lateral distal femoral angle (LDFA), and medial proximal tibial angle (MPTA) using three-dimensional reconstructed images. Intraoperatively, the actual prosthesis size and alignment were compared to the planned parameters. Postoperative outcomes, including pain levels, range of motion (ROM), and Knee Scoring System (KSS) scores, were assessed after surgery. Statistical analyses were performed to evaluate the correlation between alignment deviations and postoperative function.
Results
The AIKNEE system accurately predicted the prosthesis size in thirty-one of femoral cases (48%) and forty-seven of tibial cases (73%). Deviations of mFTA, LDFA, and MPTA from the target value were within 3° in 88%, 92%, and 95% of cases, respectively. A significant improvement was observed in postoperative pain, ROM, and KSS scores (p < 0.001). Correlation analysis revealed that greater deviations in mFTA and LDFA were associated with increased pain (p = 0.004, 0.047) and lower KSS scores (p = 0.027).
Conclusion
The AIKNEE system demonstrated promising results in predicting prosthesis size and achieved alignment within the desired range in a majority of cases. Postoperative outcomes, including pain levels and functional improvement, were favorable.
Lymph node ratio is a prognostic predictor for patients with papillary thyroid carcinoma and lateral lymph node metastasis-the result of a retrospective cohort study at a single-center with long-term follow-up time
Authors: Huang Hui , Liu Yunhe , Liu Wensheng , Ni Song , Liu Shaoyan 
Published: September 2023

Abstract
Background
Lymph node metastases (LNMs) are common in papillary thyroid carcinoma (PTC). The lymph node ratio (LNR) is suggested as a prognostic factor in many cancers. We aimed to evaluate the prognostic value of the LNR in PTC with lateral LNM.
Methods
This retrospective study reviewed the medical records of patients with PTC who underwent initial surgery in our institution from January 2000 to December 2012. The association of LNR and DSS was assessed using a Cox proportional hazards model with restricted cubic spline (RCS). Univariate and multivariate analyses were performed using Cox regression analysis to assess the factors predicting disease-specific survival (DSS).
Results
A total of 1036 patients with PTC were analyzed. After a median (range) follow-up of 90 (12–258) months, 45 patients died, 23 of whom died from thyroid cancer. The 10-year DSS for all study patients were 95.8%. Based on RCS curve analysis, a cutoff of 0.25 was selected for the LNR. A total of 587 (56.7%) patients had an LNR ≤ 0.25, and 449 (43.3%) patents had an LNR > 0.25. The 10-year DSS rates for patients with LNR ≤ 0.25 and > 0.25were 96.6% and 94.8%, respectively. Multivariate Cox regression analysis revealed that age group (HR, 9.13; 95% CI, 3.58–23.31, P < 0.001) and LNR (HR, 2.99; 95% CI, 1.22–7.33, P = 0.017) were independent predictors of DSS.
Conclusion
The results showed that an LNR greater than 0.25 was independently associated with an adverse DSS. LNR is a reliable predictor of both DSS of patients with PTC and lateral LNM.
Compartmental Mathematical Model with Optimal Control: Can awareness against Methicillin Resistant Staphylococcus aureus prevent its transmission?
Authors: Gokbulut Nezihal , Hurdoganoglu Ulas , Sultanoglu Nazife , Guler Emrah , Hincal Evren , Suer Kaya 
Published: September 2023

Abstract
The number of Methicillin Resistance Staphylococcus aureus cases in community and hospitals is on the rise worldwide. Hence, the study aimed to analyze transmission interventions and control strategies that could be used to prevent transmission in this manner. In this regard, compartmental mathematical model was used with and without an optimal control to visualize the effectiveness of awareness in interventions that could be applied in the prevention of transmission. A total of seven years of data gathered from hospital consisting of inpatients and outpatients of MRSA were used in this model. The results suggested that the number of cases of the four compartments: Community-acquired (CA) Staphylococcus aureus, CA Methicillin Resistant Staphylococcus aureus (MRSA), Hospital-acquired (HA) Staphylococcus aureus, HA-MRSA in the designed mathematical model without the control were on an increasing trend. When optimal control was applied as a second model, it was determined that increasing awareness of hand hygiene and wearing a mask were the key controlling measures to prevent the spread of CA-MRSA and HA- MRSA. Lastly, it is concluded that both CA-MRSA and HA-MRSA cases are on the rise and increasing awareness in regard to transmission is significant in preventing further spread.
Application and analysis of simulated STD clinic diagnosis and treatment combined with LBL in practice teaching of Dermatology and Venereology
Authors: Wu Ningling , Lu Jianyun , Zhou Lu , Tong Xiaoliang , Gao Lihua , Zeng Jinrong 
Published: September 2023

Abstract
Background
The currently pedagogical methodology of Dermatology and Venereology currently in the class of undergraduate students focuses more on theoretical knowledge, while neglecting the cultivation of clinical thinking, diagnosis and differential diagnosis skills. To compare the academic achievements and students’ satisfaction obtained in sexually transmitted diseases (STD) chapter according to the pedagogical methodology employed: the incorporation of stimulated outpatient diagnosis and treatment into lecture-based learning (joint lecture) versus lecture-based teaching mode (LBL).
Methods
A quasi-experimental study was designed. This study involved 346 clinical undergraduates of two academic year cohorts from Xiangya School of Medicine, Central South University, receiving instruction from the Dermatology and Venereology department of the Third Xiangya hospital. The control group were comprised of 164 students from the 2018 class, receiving the LBL methodology. While the experimental group consisted of 182 students from the 2019 class, undergoing the joint lecture. Both groups specifically focused on the practice-teaching of sexually transmitted diseases (STD) chapter in the Dermatology and Venereology course. Examination and questionnaire surveys were conducted after the course to evaluate the mastery of the students both in the control and experimental group in this chapter, as well as the interest of the students both in the joint lecture and LBL.
Results
In total, 346/346 (100%) of students completed the questionnaire and the examination. The mean scores and performance evaluations obtained in STD chapter were significantly higher in experimental group compared to the control group (P < 0.05), especially in case analysis questions and the interest of pedagogical methods. Additionally, the active learning based on joint lecture were positively emphasized. Findings demonstrated that the joint lecture improves the clinical thinking, diagnosis and differential diagnosis, enhances the subjective initiative, as well as fosters communication skills. The main weakness for this study was short of large sample size and class period.
Conclusion
The joint lecture can substantially enhance students’ theoretical achievements and interest in this subject, showing the better academic performance than those in the control group. The stimulated outpatient diagnosis and treatment in conjunction with LBL teaching mode warrant broad application prospects.
MALDI-TOF MS as one of the alternative tools for detecting outbreaks of strains carrying the carbapenemase gene
Authors: Liu Longjin , Wang Jianmin , Li Xinhui , Zhang Jisheng , Yang Yang , Gong Xue , Long Wenzhang , Jiang Shan , Wang Xiaoyu , Zhang Xiaoli 
Published: September 2023

Abstract
Background
Rapid, cost-effective, simple, and reliable bacterial typing methods are essential in clinical infection control. This study aimed to evaluate the clinical applicability and its consistency with conventional typing methods of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) typing function.
Methods
Here, we collected 126 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains and 24 Enterobacter cloacae complex (ECC) strains, grouped them according to their strain characteristics, and clustered them using different methods, including MALDI-TOF MS, multi-locus sequence typing (MLST), core genome multi-locus sequence typing (cg-MLST), pulsed-field gel electrophoresis (PFGE).
Results
The results showed that MALDI-TOF MS was poorly matched with MLST and cg-MLST. MALDI-TOF MS was in relatively high agreement with PFGE for ECC, but for CRKP we concluded that the agreement was poor. We speculated that the reasons for this discrepant result might be the large difference in the number of the two strains and the fact that CRKP strains used to compare PFGE and MALDI-TOF MS were all from the ICU unit, which has a high degree of similarity. In addition, we found three possible outbreaks in our hospital after a small cluster analysis according to the time of strain isolation as well as the departments and wards of patients.
Conclusion
Therefore, although MALDI-TOF MS is less consistent with traditional methods in typing of these specific species, it may be one of the alternative tools for detecting outbreaks of strains carrying the carbapenemase gene to facilitate rapid clinical measures to prevent further spread of the outbreak.