bluuebunny/crossref_metadata_2025_split huggingface dataset:
TNFAIP3‐interacting protein 1 (ABIN‐1) negatively regulates caspase‐8/FADD‐dependent pyroptosis
Authors: Li Xueyi , Wang Daoyong , Su Zhenyi , Mao Xiaohua 
Published: January 2025

TNFAIP3‐interacting protein 1 (TNIP1; also known as ABIN‐1) is a ubiquitin‐binding protein that suppresses death‐receptor‐ or Toll‐like receptor‐mediated apoptosis and necroptosis; however, it remains unclear whether ABIN‐1 is capable of regulating pyroptosis. In the present study, we found that, in mouse embryonic fibroblasts and macrophages, ABIN‐1 deficiency sensitized cells to poly(I:C) + TAK1 inhibitor 5Z‐7‐oxozeaenol‐induced pyroptosis besides apoptosis and necroptosis. The sensitizing effect of ABIN‐1 deficiency on pyroptosis depended on caspase‐8 and its adaptor molecule FAS‐associated death domain protein. In a mouse model of polymicrobial sepsis, myeloid‐specific deletion of Abin‐1 rendered mice more sensitive to pyroptosis, apoptosis and necroptosis, and exacerbated disease severity. Interestingly, ABIN‐1 deficiency triggered gasdermin‐E‐mediated pyroptosis in mouse embryonic fibroblasts, but induced gasdermin‐D‐mediated pyroptosis in macrophages, both in a caspase‐8‐dependent manner. Furthermore, we demonstrated that, upon poly(I:C) + 5Z‐7‐oxozeaenol stimulation, ABIN‐1 deficiency facilitates FAS‐associated death domain protein recruitment to caspase‐8; thus, the mechanism by which ABIN‐1 downregulates caspase‐8 activity is conserved in tumor necrosis factor receptor type 1 and Toll‐like receptor 3 signaling‐induced cell death. Together, our work identifies a previously unrecognized role for ABIN‐1 as a negative regulator of pyroptosis in addition to apoptosis and necroptosis, suggesting that ABIN‐1 represents a promising molecule to halt or reverse progression of refractory inflammatory disorders whose pathogenesis involves multiple forms of programmed cell death.
Contrasting Effects of Increasing Invasive Crayfish Densities on Competing Submerged Macrophytes in Shallow Lakes
Authors: Li Lei , Hilt Sabine , Ding Mingming 
Published: January 2025

ABSTRACT

Non‐native crayfish are among the most widespread aquatic invasive species worldwide. High densities of crayfish in lakes can potentially cause complete loss of macrophytes through herbivory, physical destruction, shading by suspension of sediments and nutrient release facilitating phytoplankton, thus altering ecosystem state and functions. However, lower crayfish densities may affect different macrophyte species in different ways, thus altering competition between macrophyte species with different growth forms. We hypothesize that high crayfish densities can completely destroy submerged macrophyte communities and shift systems into more turbid conditions whereas low crayfish densities can promote low‐growing macrophytes that compete with canopy‐forming species.

To test these hypotheses, we applied three different densities (2, 4, 8 crayfish m−2) of the invasive crayfish Procambarus clarkii and a control (no crayfish) to 36 mesocosms of monocultures and mixed stands of low‐growing and canopy‐forming submerged macrophytes for 60 days. We measured concentrations of nutrients, suspended solids, phytoplankton and periphyton and above‐ and belowground biomass of low‐growing Vallisneria natans and canopy‐forming Hydrilla verticillata.

In addition, we conducted a meta‐analysis of crayfish impacts on macrophytes to compare effect sizes between different crayfish densities. Using data from published studies, we derived the relationship between crayfish density and crayfish‐induced reductions in macrophyte abundance.

Our meta‐analysis revealed a significant decline of macrophytes with increasing crayfish densities. In line with existing studies, high crayfish densities caused a strong loss of both low‐growing and canopy‐forming macrophytes and increased nutrient concentrations, phytoplankton biomass and suspended sediment, thus favouring an ecosystem shift to more turbid conditions. Low and medium crayfish densities reduced macrophyte biomass similarly for both species in monocultures. However, in mixed cultures, low crayfish densities (2 crayfish m−2) reduced the above‐ and belowground biomass of the canopy‐forming H. verticillata more than that of low‐growing V. natans, supporting our hypothesis. This support of low‐growing macrophytes occurred despite a temporal facilitation of shading by increased periphyton biomass.

Our results show that the impact of crayfish invasions on aquatic ecosystems is strongly dependent on their density. High densities facilitate the loss of macrophytes and increase the likelihood of ecosystem collapse into a turbid state. However, low densities can provide a competitive advantage to low‐growing macrophytes that would otherwise be outcompeted by canopy‐forming species. Although complete eradication is often impossible, management of invasive crayfish can target densities that have potentially positive effects on invaded ecosystems.
Urinary odor molecules in the Otassha Study can distinguish patients with sarcopenia: A pilot study
Authors: Oka Takuya , Fujita Akiko , Kawai Hisashi , Obuchi Shuichi P , Sasai Hiroyuki , Hirano Hirohiko , Ihara Kazushige , Fujiwara Yoshinori , Tanaka Masashi , Kato Keiko 
Published: January 2025

AimTo identify sarcopenia markers in urinary odor.MethodsWe performed solid‐phase microextraction from the headspace and gas chromatography–mass spectrometry analysis of urinary volatile organic compounds (VOCs) in 71 healthy individuals and 68 patients diagnosed with sarcopenia according to the Asian Working Group on Sarcopenia 2019 criteria. The mass‐to‐charge ratios (m/z) of 10 VOCs with a significant difference in the total ion chromatogram of 220 VOCs detected in this study were compared by U‐test. To calculate the predictive values for sarcopenia, binomial logistic regression analyses were conducted with sarcopenia (0, 1) as the dependent variable and the m/z values of each of the 10 VOCs and all 10 VOCs as independent variables. Receiver operating characteristic (ROC) curves for predictive values were generated to evaluate diagnostic accuracy. The correlations between the predictive value and handgrip strength, usual gait speed, and skeletal muscle mass were assessed using Pearson's r.ResultsWe identified 10 VOCs (p‐xylene, 1‐butanol, d‐limonene, nonanal, pyrrole, γ‐butyrolactone, texanol isomer, octanoic acid, nonanoic acid, and diisobutyl phthalate) as candidate biomarkers in urine. The ROC curve analysis showed high diagnostic accuracy of the predictive values of the 10 VOCs for sarcopenia (area under the curve = 0.866, 95% confidence interval: 0.829–0.942; sensitivity, 80.9%; specificity, 81.7%). Additionally, the predictive values significantly correlated with handgrip strength (male: r = −0.505, P < 0.0001; female: r = −0.568, P < 0.0001).ConclusionsThis study identified 10 urinary VOCs as possible non‐invasive biomarkers for sarcopenia, offering insights into its onset mechanism and potential therapeutic targets. Geriatr Gerontol Int 2025; 25: 307–315.
The “central vein sign” to differentiate multiple sclerosis from migraine
Authors: Silvestri Giulia , Roccatagliata Luca , Tazza Francesco , Schiavi Simona , Coccia Alberto , Bandettini Di Poggio Monica , Cellerino Maria , Signori Alessio , Finocchi Cinzia , Uccelli Antonio , Inglese Matilde , Lapucci Caterina 
Published: January 2025

AbstractObjectiveTo investigate, in two cohorts including patients with multiple sclerosis (MS) and migraine, (i) the prevalence of the “central vein sign” (CVS), (ii) the spatial distribution of positive CVS (CVS+) lesions, (iii) the threshold of CVS+ lesions able to distinguish MS from migraine with high sensitivity and specificity.MethodsA total of 70 patients with MS/clinically isolated syndrome and 50 age‐ and sex‐matched patients with migraine underwent a 3‐T magnetic resonance imaging scan. The CVS was evaluated according to current guidelines, excluding eight patients with migraine who did not show white matter (WM) lesions. A receiver operating characteristic curve analysis was performed to identify the best threshold in terms of proportion of CVS+ lesions and the absolute number of CVS+ lesions able to differentiate MS from migraine.ResultsLesion volume was different between CVS+ and CVS negative lesions (median 1043 vs. 176.5 mm3 for MS cohort; median 35.1 vs. 52.2 mm3 for migraine cohort; p < 0.001 for all). A higher proportion of CVS+ lesions was associated with a higher probability of being diagnosed as MS (adjusted odds ratio 1.09, 95% confidence interval [CI] 1.04–1.14; p < 0.001). CVS+ lesion volume and number were higher in MS with respect to migraine, both considering the whole brain and its subregions (p < 0.001). The proportion of CVS+ lesions in juxtacortical and infratentorial areas was higher in MS than in migraine (p = 0.015 and p = 0.034, respectively). The best CVS proportion‐based threshold able to differentiate MS from migraine was 35.0% (sensitivity 97.1%, specificity 85.7%) with an area under the curve of 0.95 (95% CI 0.90–1.00). The “select 6” rule seemed to be preferable in terms of specificity with respect to the “select 3” rule.ConclusionsA CVS proportion‐based threshold of 35.0% is capable of distinguishing MS from migraine with high sensitivity and specificity. The “select 6” algorithm may be useful in the clinical setting.
Efficiency in Higher Education: A Review of Research From 1977 to 2022
Authors: Jain Itisha , Gulati Rachita 
Published: January 2025

ABSTRACTThis paper provides a comprehensive survey of studies on the measurement of frontier efficiency in higher education. We review the database of 89 studies assessing higher education efficiency by applying both parametric and non‐parametric methods. For the selection of studies, the Scopus‐indexed journals from 1977 to 2022 are screened and methodically chosen. The analysis presents a classification of research in this area by trends, influential authors and works, emerging issues, primary inputs and outputs, efficiency measurement level, higher education efficiency principles, and estimating methodologies. We note the exponential growth of research on efficiency measurement in higher education from 2011 to 2022. Most evidence is from developed nations like Italy, the UK, China, Australia, and Germany, with more scope for research on higher education in developing nations. The subject analysis reveals that student and departmental investigations need more attention and can lead to groundbreaking research. The survey findings indicate that future researchers should emphasise privatisation, third‐mission activities, social responsibility, and higher education spending.
Negative thermal expansion of LiAlSiO4 interlayer with AgCuTi filler for brazing SiC joints
Authors: Jiang Jian , Wang Gang , Wang Hao , Zhao Yu , Han Ao , Dai Bisheng , He Rujie , Cao Xuelong 
Published: January 2025

AbstractIn order to relieve the residual stresses generated in SiC joints during brazing, LiAlSiO4‐reinforced AgCuTi/Cu‐foam composite interlayer was prepared. The typical interfacial structure of SiC joints was SiC/TiC/Ti5Si3 + Cu4Ti3 + CuTi + LiAlSiO4 + Cu (s, s) + Ag (s, s)/TiC/Ti5Si3/SiC. The effects of different process parameters and LiAlSiO4 additions on the microstructure and shear strength of the joints were investigated. The maximum shear strength of SiC was 118.7 MPa at 890°C for 10 min with LiAlSiO4 addition of 1 wt%, which is 94.5 MPa higher than that of SiC joints without LiAlSiO4. In addition, the theoretical calculations effectively proved that the addition of LiAlSiO4 can relieve the residual stresses in the joints effectively.
Anisotropic response of bidirectionally ice‐templated alumina/epoxy composites
Authors: Tiwari Sudhendu N. , Kumar Vinay , Agnihotri Prabhat K. 
Published: January 2025

AbstractThis work investigates the anisotropic response of nacre‐like lamellar alumina/epoxy composites at low and high strain rates. Ice‐templated alumina with long‐range aligned porous lamellar structures is fabricated at 20 vol% of ceramic part using bidirectional freeze casting method. The obtained porous structures are infiltrated with epoxy to fabricate lamellar alumina/epoxy composites. The compressive tests are performed on scaffolds and composites at different orientations relative to the freezing direction. The testing results reveal that infiltration has increased the uniaxial compressive strength of the scaffold substantially. The compressive properties are higher when loaded along the freezing direction, and it decreases when it is loaded away from the freezing direction. The strength of the composites exhibited a strong dependency on the loading direction and strain rates.
Sleep‐disordered breathing and cardiometabolic and inflammatory markers in children with overweight/obesity: The role of cardiorespiratory fitness
Authors: Torres‐Lopez Lucia V. , Plaza‐Florido Abel , Gil‐Cosano Jose J. , Migueles Jairo H. , Ortega Francisco B. , Cadenas‐Sanchez Cristina 
Published: January 2025

SummaryObjectivesTo investigate the association of sleep‐disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.MethodsA total of 109 children aged 8–11 years with overweight/obesity were included in this cross‐sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire. Cardiometabolic markers included fasting blood lipids biomarkers (i.e., low‐ and high‐density lipoprotein cholesterol, and triglycerides), blood pressure, insulin, glucose, and the homeostatic model assessment index. Inflammatory markers (i.e., interleukin‐6, interleukin‐1β, C‐reactive protein [CRP], and tumour necrosis factor alpha) were analysed. Cardiorespiratory fitness was assessed by the 20 m shuttle‐run test.ResultsNo significant associations were found between SDB severity and most of the cardiometabolic markers after correcting for adiposity and multiple comparisons (all p's >0.05). SDB severity was positively related to CRP (β = 0.352, p = 0.002), yet not with the remaining inflammatory markers analysed. The interaction effect of cardiorespiratory fitness presented a positive trend in the association of SDB with CRP (p = 0.1). When stratified analyses by cardiorespiratory fitness levels were conducted, a positive relation was found between SDB and CRP in the low cardiorespiratory fitness group (β = 0.465, p = 0.014), but not in the high cardiorespiratory fitness group (β = 0.236, p = 0.108).ConclusionSDB severity was positively associated with CRP independently of the adiposity levels, but not with other inflammatory or cardiometabolic risk factors in children with overweight/obesity. Moreover, our results suggest that higher levels of cardiorespiratory fitness may attenuate the adverse effect of SDB severity on systematic inflammation in children with overweight/obesity.
What Is Wrong with Workism?
Authors: Hammerton Matthew 
Published: January 2025

ABSTRACTWorkism is the phenomenon of people making their work the primary source of meaning and identity in their life. Recent critics of workism have argued that there is a growing trend towards it in many societies and that this is a bad thing. This article brings a philosophical perspective to the debate on workism. It develops a precise account of what workism is and evaluates the main objections raised against it by examining their underlying philosophical assumptions. Ultimately, it is argued that workism, as a way of life, is not as objectionable as its critics suggest.
Revisiting the phylogeny of Primulaceae s.l. using whole plastid genomes: Highlighting phylogenetic conflicts and their implications
Authors: Yan Hai‐Fei , Liu Tong‐Jian , Yuan Xun , Xu Yuan , Zhang Shu‐Yan , Hao Gang , Ge Xue‐Jun 
Published: January 2025

AbstractThe family Primulaceae s.l. is estimated to comprise approximately 60 genera and 2600 species worldwide. Although extensive research has been conducted on the family Primulaceae and its subfamily boundaries, there is a lack of systematic studies utilizing complete plastid genome data, leading to uncertainties in the phylogenetic positions of certain key taxa, such as Stimpsonia. In this study, plastid genomic data were collected from 67 accessions representing four subfamilies and 28 genera within the Primulaceae family. Phylogenetic trees were constructed using coalescent and concatenated approaches to elucidate the evolutionary history of the family. By employing a comprehensive dataset of 67 plastid genomes from all four subfamilies, a robust phylogenetic framework for the family was established. Contentious relationships were identified at the early stages of divergence in Primula and among Cyclamen and its relatives, probably due to rapid diversification. Our plastid genomic data support the idea that Stimpsonia is sister to the remainder of the subfamily Primuloideae, in contrast with its placement in Myrsinoideae based on nuclear data. A cytonuclear discordance in the phylogenetic position was also detected in Aegiceras corniculatum. The divergence time estimates from this study align with previous findings, indicating significant diversification events during the Eocene and Oligocene epochs. These timeframes coincide with major geological and climatic changes, which were likely to have influenced the distribution and diversification of Primulaceae. These results underscore the complex evolutionary history of the Primulaceae family and lay the groundwork for future research aimed at unraveling the intricate evolutionary dynamics within this family.
Quantitative Fundamental Theorem of Asset Pricing
Authors: Acciaio Beatrice , Backhoff‐Veraguas Julio , Pammer Gudmund 
Published: January 2025

ABSTRACTIn this paper, we provide a quantitative analysis of the concept of arbitrage, that allows us to deal with model uncertainty without imposing the no‐arbitrage condition. In markets that admit “small arbitrage,” we can still make sense of the problems of pricing and hedging. The pricing measures here will be such that asset price processes are close to being martingales, and the hedging strategies will need to cover some additional costs. We show a quantitative version of the fundamental theorem of asset pricing (FTAP) and of the super‐replication theorem. Finally, we study robustness of the amount of arbitrage and existence of respective pricing measures, showing stability of these concepts with respect to a strongly adapted Wasserstein distance.
Evolutionary analysis of a coupled epidemic‐voluntary vaccination behavior model with immunity waning on complex networks
Authors: Meng Xueyu , Fan Yufei , Qiao Yanan , Lin Jianhong , Cai Zhiqiang , Si Shubin 
Published: January 2025

AbstractVaccination is the most effective method of preventing and controlling the transmission of infectious diseases within populations. However, the phenomenon of waning immunity can induce periodic fluctuations in epidemic spreading. This study proposes a coupled epidemic‐vaccination dynamic model to analyze the influence of immunity waning on the epidemic spreading within the context of voluntary vaccination. First, we establish an SIRSV (susceptible–infected–recovered–susceptible–vaccinated) compartment model to describe the transmission mechanism of infectious diseases based on the mean‐field theory. Within this model, we incorporate a nonlinear infection rate with network topology and consider the waning natural and vaccine‐induced immunity at the individual level. The evolutionary model of voluntary vaccination strategy is integrated into the SIRSV model to characterize the impact of vaccination behavior on the infectious disease transmission. We also consider two individual risk assessment methods, namely, the individual‐based risk assessment (IB‐RA) method and the society‐based risk assessment (SB‐RA) method, originating from local and global perspectives, respectively. Then, utilizing the next‐generation matrix method, we derive the time‐varying effective reproduction numbers of the model. Also, the theoretical analysis of optimal strategy thresholds in the individual decision‐making process is also conducted. The results indicate that the thresholds obtained from the agent‐based model (ABM) simulation method are consistent with the theoretical analysis, demonstrating the effectiveness of our model. Finally, we apply the coupled model to the COVID‐19 pandemic in France, Germany, Italy, and the United Kingdom. This study analyzes the impact of waning immunity and provides early warning for the outbreak of the epidemics.
Managing and mitigating future public health risks: Planetary boundaries, global catastrophic risk, and inclusive wealth
Authors: McLaughlin Eoin , Beck Matthias 
Published: January 2025

AbstractThere are two separate conceptualizations for assessing existential risks: Planetary Boundaries (PBs) and global catastrophic risks (GCRs). While these concepts are similar in principle, their underpinning literatures tend not to engage with each other. Research related to these concepts has tended to be siloed in terms of the study of specific threats and also in terms of how these are assumed to materialize; PBs attribute global catastrophes to slow‐moving and potentially irreversible global changes, while GCRs focuses on cataclysmic short‐term events. We argue that there is a need for a more unified approach to managing global long‐term risks, which recognizes the complex and confounded nature of the interactions between PBs and GCRs. We highlight where the PB and GCR concepts overlap and outline these complexities using an example of public health, namely, pandemics and food insecurity. We also present an existing indicator that we argue can be used for monitoring and managing risk. We argue for greater emphasis on national and global ‘‘inclusive wealth’’ as a way to measure economic activity and thus to monitor and mitigate the unintended consequences of economic activity. In sum, we call for a holistic approach to stewardship aimed at preserving the integrity of natural capital in the face of a broad range of global risks and their respective regional or global manifestations.
The use of public spatial databases in risk analysis: A US‐oriented tutorial
Authors: Greenberg Michael R. , Schneider Dona , Cox Louis Anthony 
Published: January 2025

AbstractThis tutorial focuses on opportunities and challenges associated with using six large, publicly accessible spatial databases published during the last decade by US federal agencies. These databases provide opportunities for researchers to risk‐inform policy by comparing community asset, demographic, economic, and social data, along with anthropogenic and natural hazard data at multiple geographic scales. The opportunities for data analysis come with challenges, including data accuracy, variations in the shape and size of data cells, spatial autocorrelation, and other issues endemic to spatial datasets. If ignored, these issues can lead to misleading results. This article briefly reviews the six databases and how agencies use them. It then focuses on the data and its limitations. Examples are provided, as are summaries of the debates surrounding these databases, followed by paths forward for improving their use. We end with a checklist that users should consider when they access any of the six spatial databases or others. We believe that these new resources can be effectively used with appropriate caution to answer user‐generated questions about hazards and risks—questions that are important to both community groups and government decision‐makers.