bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of thyroid function with renal hemodynamics and cholesterol metabolism in proteinuric kidney disease: A pilot study
Authors: Iwazu Yoshitaka , Kotani Kazuhiko , Sugase Taro , Nagata Daisuke , Yamada Toshiyuki 
Published: May 2023

Abstract
Purpose. Nephrotic syndrome and hypothyroidism are respectively reported to influence renal hemodynamic and hypercholesterolemia. However, the relationship of proteinuria-associated thyroid function with renal hemodynamics and cholesterol metabolism has yet to be determined in a simultaneous analysis of thyroid, renal and cholesterol variables. We investigated the hypothesis that the changes in thyroid hormones by proteinuria may contribute to changes in lipid metabolism and renal hemodynamics by proteinuria.
Methods. Twenty-nine patients (17 men) with proteinuric kidney disease (mean age 46 years) were enrolled in a pilot study. Data for serum free triiodothyronine (FT3), free thyroxine (FT4), total cholesterol, and filtration fraction (FF; assessed by para-aminohippuric acid clearance) were used in variable-adjusted correlation analyses.
Results. The patients had the following data (mean ± standard deviation): urinary protein 5.18 ± 3.28 g/day, FT3 2.18 ± 0.44 pg/mL, FT4 1.03 ± 0.26 ng/dL, FF 0.27 ± 0.07, and total cholesterol 327 ± 127 mg/dL. There was a significant positive correlation of FT3 with FF (β = 0.58, P = 0.01) and a significant inverse correlation of FT4 with total cholesterol (β = -0.40, P = 0.01).
Conclusions. The proteinuria associated reduction in serum thyroid hormone levels may be involved in a part of hypercholesterolemia and the impaired glomerular function due to nephrotic syndrome. Further studies of these relationships are required.
Omicron variant BA.1, BA.5, BQ.1.1, and XBB.1.5 Neutralizing Antibodies Following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 Bivalent Vaccination
Authors: Hladunewich Michelle , Yau Kevin , Kurtesi Alexandra , Qi Freda , Delgado-Brand Melanie , Tursun Tulunay , Hu Queenie , Dhruve Miten , Kandel Christopher , Enilama Omosomi , Levin Adeera , Jiang Yidi , Hardy William , Yuen Darren , Perl Jeffrey , Chan Christopher , Leis Jerome , Oliver Matthew , Colwill Karen , Gingras Anne-Claude 
Published: May 2023

Abstract

Neutralization of Omicron subvariants by different bivalent vaccines have not been well evaluated. This study characterized neutralization against Omicron subvariants in 98 individuals receiving dialysis or with a kidney transplant receiving the BNT162b2 (BA.4/BA.5) or mRNA-1273 (BA.1) bivalent COVID-19 vaccine. Neutralization against Omicron BA.1, BA.5, BQ.1.1, and XBB.1.5 increased by 8-fold one month following bivalent vaccination. In comparison to wild-type (D614G), neutralizing antibodies against Omicron-specific variants were 7.3-fold lower against BA.1, 8.3-fold lower against BA.5, 45.8-fold lower against BQ.1.1, and 48.2-foldloweragainst XBB.1.5. Viral neutralization was not significantly different by bivalent vaccine type for wild-type (D614G) (P=0.48), BA.1 (P=0.21), BA.5 (P=0.07), BQ.1.1 (P=0.10), nor XBB.1.5 (P=0.10). Hybrid immunity conferred higher neutralizing antibodies against all Omicron subvariants. Given that both BNT162b2 (BA.4/BA.5) and mRNA-1273 (BA.1) induced similar neutralization against all Omicron subvariants, this suggests that bivalent vaccines confer protection even when they are antigenically divergent from the circulating variant.
Why Do People Hurt Themselves? A study of aggression toward self in drug dependence
Authors: Xin Yong , Fu Haojie , Xin Wei , Wang Bin , Zhong Xiao , Hu Ruilin , Zhang Xiaoqian , Liu Chuanjun 
Published: May 2023

Abstract
Background: The negative consequences of drug addiction can include increased aggression, and previous research has suggested a correlation between drug addiction and self-harm. However, the relationship between childhood trauma, self-aggression, and drug addiction has not been extensively investigated.
Methods: The present study to explore the influence of childhood trauma on self-aggression in drug users under the age of 16, used the benefits and barriers model. The study analyzed the distal factors of self-aggressive intention in compulsory drug addicts and examined the mediating role of sense of life meaning as a barrier factor and sensation seeking as a benefit factor. To collect data, the Childhood Trauma Questionnaire (CTQ), the Presence of Meaning in Life (MLQ-P), the Brief Sensation Seeking Scale (BSSS), and Aggression toward Self Scale (ATS) were administered to 625 male compulsory detoxification patients in a Sichuan compulsory detoxification facility.
Results: The results showed no significant difference in self-aggression between methamphetamine and heroin addicts and identified a significant mediating effect of MLQ-P as a barrier factor and BSSS as a beneficial factor in predicting self-aggression.
Conclusions: This study confirmed the applicability of the benefits and barriers model in the drug addicts, and proposed a parallel mediation model of CTQ affecting ATS with MLQ-P and BSSS as mediator variables. It can provide a theoretical basis for intervention in the recovery of drug addicts.
The Emotions, Coping Strategies and Learning Behaviours of Medical Students during Quarantine Period of COVID-19
Authors: Tanriover Ozlem , Peker Sukran , Hidiroglu Seyhan , Kitapcioglu Dilek , Gülpınar M. Ali 
Published: May 2023

Abstract
Objective: The aims of this study were to identify the emotions of medical students during quarantine period, to clarify how they coped with this new situation and to find out whether learning behaviors changed due to pandemic.
Participants: Quarantined medical students participating in the distance education program of a medical school during the pandemic.
Methods: In this descriptive study we have utilized online questionnaire in gathering the information. The Positive and Negative Affect Scale was also used to find out the emotion spectrum of medical students.
Results: In our sample, medical students mostly had negative emotions. The students with high negative affect scores were unable to cope with stress and unable to use emotional regulation strategies which impacted their learning behaviors.
Conclusions: The emotions should be explicitly reflected in medical education and the students should be supported in coping with these emotions as part of their professional growth and well-being.
Discerning the roles of various reactive oxygen species on PFOA degradation
Authors: Yang Jin , Xiao Ye , Wang Yue , Tang Qin , Zhu Xiaomin , Zhang Weihua , Qiu Rongliang 
Published: May 2023

Abstract
Perfluorooctanoic acid (PFOA) is a widely distributed persistent organic pollutant in the environment. In recent years, various advanced oxidation processes (AOP) have been explored to degrade PFOA in aqueous solution, but the roles of reactive oxygen species (ROS) such as hydroxyl radical (·OH), superoxide anion radical (O2·−), and hydroperoxide anion (HO2−) on PFOA degradation were not clear or with even controversial conclusions. Here, we investigated three AOP systems, including the catalytic hydrogen peroxide process, the electro-Fenton system, and the anodic oxidation process, capable of producing different ROS, for PFOA degradation. Essentially no fluoride ion was detected after the reaction if only homogeneous free ·OH, O2·−, and HO2− were present in the system indicating their ineffectiveness in PFOA degradation. Further experiments demonstrated that valence band holes (h+) and adsorbed hydroxyl radicals (·OH) on the anode surface governed the electrochemical mineralization of PFOA. In addition, the simultaneous TOC removal and defluorination by anodic oxidation degradation using a boron-doped diamond (BDD) electrode implied that the intermediates of PFOA degradation were rapidly decomposed on the electrode surface. This research provides insights on the role of ROS during PFOA degradation by AOP technologies.
Predicting postpartum hemorrhage in women undergoing planned cesarean section: a multicenter retrospective cohort study in Japan
Authors: Yamaguchi Tomoko , Kyozuka Hyo , Ito Momoka , Hiraiwa Tsuyoshi , Murata Tsuyoshi , Sugeno Misa , Ito Fumihiro , Suzuki Daisuke , Fukuda Toma , Yasuda Shun , Keiya Fujimori , Nomura Yasuhisa 
Published: May 2023

Abstract
Background Given Japan’s unique social background, it is critical to understand the current risk factors for postpartum hemorrhage (PPH) to effectively manage the condition, especially among specific groups. Therefore, this study aimed to clarify the current risk factors for blood loss during planned cesarean section (CS) in Japan.Methods This multicenter retrospective cohort study was conducted in two tertiary maternal-fetal medicine units in Fukushima, Japan and included 1,133 women who underwent planned CS between January 1, 2013, and December 31, 2022. Risk factors for PPH (of > 1000 g, > 1500 g, and > 2000 g) were assessed using multivariate logistic regression analysis, considering variables such as maternal age, parity, assisted reproductive technology (ART) pregnancy, pre-pregnancy body mass index (BMI), uterine myoma, placenta previa, gestational age at delivery, birth weight categories, and hypertensive disorders of pregnancy (HDP). Multivariate linear regression analyses were conducted to predict PPH risk during planned CS.Results ART pregnancy, pre-pregnancy BMI (25.0–29.9 kg/m2), placenta previa, and uterine myoma increased PPH risk at various levels. Maternal smoking increased the risk of > 2000 g PPH (adjusted odds ratio: 11.6, 95% confidence interval [CI]: 2.85–46.9). Multivariate linear analysis showed that advanced maternal age (B: 75 g; 95% CI: 21–128 g), ART pregnancy (B: 163 g; 95% CI: 50–275 g), pre-pregnancy BMI of 25.0 to < 30.0 kg/m2 (B: 94 g; 95% CI: 22–167 g), uterine myoma (B: 189 g; 95% CI: 89–288 g), placenta previa (B: 558 g; 95% CI: 453–662 g), and birth weight > 3,500 g (B: 173 g; 95% CI: 44–303 g).Conclusions Considering a patient’s social background may help predict bleeding in planned CSs and help improve patient safety.
Effect of bleeding to Actinidia arguta (Sieb. &amp; Zucc) Planch. ex Miq. on plant growth, physiological characteristics and fruit quality
Authors: jiang yaxuan , Lei Pei , Ma Le , Dong Kun , Zhang Yu , Zhao Jia , Guo Xinyu , Liu Jianxin , Li Wei , Tao Lei , Meng Fanjuan 
Published: May 2023

Abstract
Bleeding, as particularly serious phenomenon in A. arguta, has an important effect on plant growth and development. In the study, to study the effects of bleeding on the growth and development of leaves and fruits after the occurrence of bleeding, we chose as Actinidia arguta (Sieb. & Zucc) Planch. ex Miq. Results revealed that bleeding damaged the leaf structure. The physiological indexes of plants after bleeding were detected and analyzed. The relative electrical conductivity and malondialdehyde (MDA) of leaves increased in treatment. Nitro blue tetrazolium chloride (NBT) and 3,3-diaminobenzidine (DAB) staining showed that reactive oxygen species (ROS) accumulation was obvious in leaves after bleeding. The chlorophyll content, Tr (transpiration rate), Pn (net photosynthetic rate), Ci (intercellular CO2 concentration) and Gs (stomatal conductance) of plants were also decreased. The pulp and the seed water content decreased after the damage. The fruit vitamin C, soluble sugar content and soluble solids content (SSC) decreased after the damage, but the titratable acid content had no significant difference. Therefore, the bleeding will affect the physiological indexes of A. arguta, and our study lay a theoretical basis for understanding the physiological changes of A. arguta after bleeding.
Modeling and optimization of PEA- combined grinding aids effect in grinding circuit of cement ball mill
Authors: fatahi Rasoul , Pournazari Ali , Ghorbani Habib , Shah Majid Parvez , tazik Saeed Hosseini , Abdollahi Hadi 
Published: May 2023

Abstract
In this study, while introducing the new combination of by-products of petrochemical companies as a GAs and their combination with water, the optimization and modeling of essential parameters affected by GAs in ball mills have been discussed. According to Central Composite Design, the experiment was designed and implemented with Response Surface Methodology, and a quadratic model for regression analysis (R2 = 0.969) was developed. The effects of essential parameters, including feed rate of the mill, Blaine and dosage rate of GAs, were investigated to find the best efficient conditions and were found to be 121ton/hr: 388.578 l/t and 3650 cm2/gr, respectively. Under these conditions, the power consumption of the mill was found to be 4228.61 kW. Also, optimal conditions were established in industrial grinding processes. The results demonstrated that mill feed rate capacity changes could be obtained at approximately 12.69%. Sieve residue under 90µ in different fractions shows that grinding aid usage has raised the fineness product of the mill by inserting cement PSD and Blaine in a suitable range. Also, using the study done in two similar cement ball mills in the same cement plant, almost 1000000-ton cement was produced.
Central nervous system (CNS) Varicella Zoster encephalitis and vasculopathy in an immunocompetent patient Case Report
Authors: Ghapar Amirul Ab , Zakaria Nurul Izzati , May Low Huik , Yahya Noor Hidayah , Salim Iffah 
Published: May 2023

Abstract
Background Varicella zoster virus (VZV) infection, which affects the central nervous system (CNS) in adult patients, may occur with or without concurrent shingles. CNS manifestations include encephalitis and vasculopathy, the latter often manifesting as stroke due to ischaemic lesions involving small arteries. Immunocompromised individuals and those of advanced age are more prone to develop severe disease and also CNS involvement following VZV infection. We present a case of VZV encephalitis and vasculopathy, its symptoms and physical findings that should raise clinical suspicion of the disease, and its treatment and prognosis.Case presentation A 61-year-old man who presented to the emergency department with shingles and altered mental status was diagnosed with encephalitis and ischaemic stroke. Intravenous acyclovir was administered. VZV DNA and serology was detected in his CSF. Enhanced computed tomography (CT) of the brain showed multifocal non-enhancing hypodensities in cortical and subcortical areas. A diagnosis of VZV CNS encephalitis and vasculopathy was made and intravenous acyclovir was continued for 21 days and a short course of prednisolone was prescribed. Magnetic resonance imaging of the brain on subsequent follow-up showed cortical haemorrhage in the remaining areas, but this was less compared to the initial imaging.Conclusion Neuroimaging can detect ischaemic stroke and detection and VZV CSF PCR is a reliable diagnostic tool, as shown in this case. Antiviral treatment and short-term steroid administration can improve outcome. This clinical case highlights the importance of recognition and challenge in the diagnosis of VZV CNS vasculopathy in immunocompetent patients.
Adverse effects of the long-term use of an N95 mask in healthcare workers
Authors: Takami Hiroki , Mitsuhashi Takashi , Nomura Tomohisa , Sugita Manabu , Usuda Daisuke 
Published: May 2023

Abstract
Purpose Healthcare workers must take stringent infection control measures against coronavirus disease. Previous reports have indicated that N95 masks cause fatigue, discomfort, and physical symptoms, such as headaches. We aimed to comparatively analyze the effect of the use of surgical and N95 masks for long hours on the performance of healthcare workers.Methods Healthy healthcare workers at an emergency department were subjected to a performance test program comprising four tests conducted before and after wearing a surgical mask/N95 mask for at least 4 h, and the results were compared.Results The study included 17 (male, 8 [47.1%]) healthcare workers. The age ranged from 22 to 32 (mean, 26.6) years. For each test, the rate of change in the percentage of correct responses, rate of decline in reaction time, and rate of decline in reaction time for correct responses were calculated before and after wearing the two types of masks. There was no statistically significant difference in the rate of decline in reaction time between the masks for all tests. However, there was a trend toward a high rate of decline in the alphanumeric detection test.Conclusion Using an N95 mask for 4 h continuously did not adversely affect work efficiency. Although prolonged work under conditions of discomfort should be avoided, it is unlikely that N95 masks will directly adversely affect the performance of healthcare workers.
Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia
Authors: Kaur Satvinder , Nicole Lynch , Sela Yaniv , Lima Janayna , Thomas Renner , Bandaru Sathyajit , Saper Clifford 
Published: May 2023

Abstract

Although CGRP neurons in the external lateral parabrachial nucleus (PBelCGRP neurons) are critical for cortical arousal in response to hypercapnia, activating them has little effect on respiration. However, deletion of all Vglut2 expressing neurons in the PBel region suppresses both the respiratory and arousal response to high CO2. We identified a second population of non-CGRP neurons adjacent to the PBelCGRP group in the central lateral, lateral crescent and Kölliker-Fuse parabrachial subnuclei that are also activated by CO2 and project to the motor and premotor neurons that innvervate respiratory sites in the medulla and spinal cord. We hypothesize that these neurons may in part mediate the respiratory response to CO2 and that they may express the transcription factor, Fork head Box protein 2 (FoxP2), which has recently been found in this region. To test this, we examined the role of the PBFoxP2 neurons in respiration and arousal response to CO2, and found that they show cFos expression in response to CO2 exposure as well as increased intracellular calcium activity during spontaneous sleep-wake and exposure to CO2. We also found that optogenetically photo-activating PBFoxP2 neurons increases respiration and that photo-inhibition using archaerhodopsin T (ArchT) reduced the respiratory response to CO2 stimulation without preventing awakening. Our results indicate that PBFoxP2 neurons play an important role in the respiratory response to CO2 exposure during NREM sleep, and indicate that other pathways that also contribute to the response cannot compensate for the loss of the PBFoxP2 neurons. Our findings suggest that augmentation of the PBFoxP2 response to CO2 in patients with sleep apnea in combination with inhibition of the PBelCGRP neurons may avoid hypoventilation and minimize EEG arousals.
Mind wandering enhances predictive processing
Authors: Vékony Teodóra , Farkas Bence , Brezóczki Bianka , Mittner Matthias , Csifcsák* Gábor , Simor* Péter , Nemeth* Dezso 
Published: May 2023

Abstract

This study investigated the potential adaptive aspects of mind wandering (MW), a common phenomenon in which individuals shift their attention from external tasks to internal thoughts. Despite the well-documented negative effects of MW on cognitive performance and links to psychiatric conditions, there is a scarcity of direct evidence of its potential benefits. In our preregistered study, we simultaneously assessed visuomotor task performance as well as the capability to extract probabilistic information from the environment while assessing task focus (on-task vs. MW). We found that MW facilitated the extraction of hidden, but predictable patterns from a stream of visual inputs. Moreover, MW influenced speed/accuracy tradeoff by shifting participants towards a faster but less accurate response style. These findings suggest that MW may have functional relevance in human cognition and everyday functioning by shaping behavior and predictive processes. Overall, our results highlight the importance of considering the adaptive aspects of MW, and its potential to enhance cognitive abilities.
The effect of percussion, diuresis and inversion therapy on retrograde intrarenal surgery success for lower renal pole stones: a prospective randomized controlled study
Authors: Sarioglu Caglar , Senel Samet , Uzun Emre , Polat Muhammed Emin , Ceviz Kazim , Odabas Oner , Koudonas Antonios 
Published: May 2023

Abstract
Inversion of the patient, forced diuresis after hydration, and mechanical percussion technique was developed for lower renal pole (LRP) stones with extracorporeal shock wave (ESWL) by considering the geometric obstacles to reverse the factors that complicate the removal of stones. In this study, we aimed to analyze the effect of percussion, diuresis and inversion (PDI) therapy on the success rates of retrograde intrarenal surgery (RIRS) for the LRP stones. 114 patients who underwent RIRS for LRP stones < 2cm were included in this study. Patients' age, gender, body mass index (BMI), preoperative double J (DJ) stent presence, ESWL history, operation time, stone size, number, density, number (single or multiple), side (left-right), infundibulopelvic angle (IPA), infundibular length (IL), infundibular width (IW) and success status were recorded prospectively. The patients were divided into two groups. One group received RIRS procedure only (non-PDI group) and the other group received PDI therapy after the RIRS procedure (PDI group). Two groups were compared in terms of the parameters above. PDI was performed to 60 (52.6%) patients, and not performed to 54 (47.4%) patients. The success rate (58.3%) for the PDI group was higher than the non-PDI group (25.9%), and this difference was statistically significant (p < 0.001). In multivariate logistic regression analysis, stone size (OR = 1.306; 95% CI = 1.019–1.674; p < 0.001), IU (OR = 1.702; 95% CI = 1.383–2.096; p < 0.001) and not performing PDI therapy (p < 0.001) OR = 9.455; 95% Cl = 2.426–10.853; p = 0.001) were revealed to be independent risk factors for failure. In conclusion, PDI therapy increases the success rates of RIRS performed for the LRP stones.
Activation of CTNNB1 by deubiquitinase UCHL3 mediated stabilization facilitates bladder cancer progression
Authors: liu tao , fan mengqi , xie Xiao-Xiao , shu qipeng , du xuehua , qi lingzhi , zhang xiaodong , zhang minghui , du runlei , li shangze 
Published: May 2023

Abstract
The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Emerging studies have suggested that its hyperactivation is closely related to the occurrence and development of bladder cancer(BCa). Here, we report that UCHL3(Ubiquitin C-terminal hydrolase L3), a deubiquitinating enzyme promotes the development of bladder cancer through Wnt signaling pathway by interacting with and stabilizing CTNNB1 in vitro and in vivo. GSEA analysis showed that UCHL3 was highly associated with Wnt signaling pathway, and it was validated by luciferase reporter assays and RT-PCR, which found that its functions depend on its deubiquitinating activity. We also found that the overexpression of UCHL3 boosted the bladder cancer cells proliferation, invasion and migration, while the depletion of UCHL3 in bladder cancer cells delayed the tumor tumorigenesis in vitro and in vivo. Especially, Uchl3-deficient mice were less susceptible to bladder tumorigenesis. Additionally, UCHL3 was highly expressed in bladder cancer and associated with advanced clinicopathological parameters. These findings provided direct insight into the molecular mechanism of the functions of UCHL3 in bladder cancer, and provided new target for therapeutic approach against bladder cancer.