bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laryngeal Abscess: A 34-Year Review
Authors: Veiga-alonso Aida , Cobo-Díaz Ramón , Salvatierra-Vicario Belén , Corriols-Noval Patricia , Morales-Angulo Carmelo 
Published: January 2025

Abstract
This study aimed to investigate the frequency, clinical-epidemiological characteristics, and management of laryngeal abscesses in our hospital setting. We included all patients treated for primary laryngeal abscesses in the Otorhinolaryngology Department of a tertiary hospital over a 34-year period. Patients with abscesses believed to have originated from adjacent regions were excluded. Thirteen patients with laryngeal abscesses were identified, with epiglottitis being the most common etiology (61%). Three patients were immunosuppressed. Four patients required urgent tracheotomy, and one underwent cricothyrotomy due to upper airway obstruction. All cases were drained under general anesthesia via a transoral route. Five patients required admission to the intensive care unit, and two experienced severe complications. There were no fatalities. Laryngeal abscesses are rare, with epiglottitis being the predominant cause. These cases pose a high risk of upper airway obstruction, highlighting the importance of early diagnosis and prompt treatment by a multidisciplinary team to prevent complications.
Optimising geotrail planning by leveraging least-cost path for sustainable geotourism development: a case study on a Tasmanian west coast post-mining landscape
Authors: Williams Mark A. , Rolls Stephen , McHenry Melinda T. 
Published: January 2025

Abstract
Geotrails serve as educational journeys that highlight significant geodiversity and cultural heritage, offering recreational and interpretive experiences in a range of constructed and natural environments. There is a growing need for objective methods to support decision-making in geotrail design. The Least-Cost Path (LCP) method, a resistance-based model, is effective for identifying routes suitable for geotrail development. Stakeholder-led design ensures the geotrail aligns with user needs. To date, there has not been a study in which a combination of LCP methods used in GIS trail design have been used in association with user persona profiles to design putative geotrails. We present a geotrail assessment methodology using LCP combined with the Analytic Hierarchy Process (AHP) that could enable geotourism practitioners to tailor trails to specific requirements, such as best practice requirements, or for various user personas. In-field validation via GNSS survey refined our LCP approach and enabled geotrail revision for similar or reduced cost after revised priorities and ranking of field criteria were incorporated. A case study on the West Coast of Tasmania, a mostly mountainous, wild landscape with mining operations of (geo)heritage significance, was conducted. Three putative geotrails were designed and field-validated, targeting users interested in mining heritage, natural values, and wilderness adventure experiences. Results showed that the validated LCP model closely adhered to trail best practices, making it suitable for planners and geotourism practitioners. Field validation decreased the overall cost of geotrails, improved accessibility, compliance with environmental and maintenance standards, safety considerations, and user experience. Additionally, a Python toolbox was created to ensure replicability of the workflow, accessible to geotourism practitioners globally. This approach to geotrail planning supports optimal routes, educational value, and sustainable development in post-mining landscapes and other geotourism areas.
Quantitative characterization of the multiscale mechanical properties of low-permeability sandstone roofs of coal seams based on nanoindentation and triaxial tests and its implications for CO2 geological sequestration
Authors: Cao Feng , He Jianhua , Cao Hongxiu , Deng Hucheng , La Croix Andrew D. , Jiang Rui , Li Ruixue , Li Jiarun 
Published: January 2025

Abstract
Microstructural heterogeneity of low-permeability sandstone roofs of deep unmineable coal seams due to diagenesis significantly affects rock mechanical behavior, greatly impacting the sealing potential of in situ CO2 sequestration and the structural stability of the geological formation. However, little is known about how the microstructure of different mineral groups influences the multiscale mechanical behavior of deep sandstone. This study proposes a new method for quantitatively characterizing the multiscale mechanical properties of low-permeability sandstone and shows the mechanisms responsible for mechanical failure at the micro-, meso-, and macroscale. Triaxial compression tests and targeted nanoindentation tests were conducted to assess the micro- and macroscale mechanical properties of different types of sandstone. The micro- and macroscale experiments were coupled with numerical simulations of compression using a unified cohesive model based on Voronoi polygons to clarify the multiscale mechanical behavior. The results indicate that quartz, the primary mineral component of the sandstones examined, exhibits the strongest micromechanical properties, followed by feldspar, calcite, and clay minerals. Compared to polycrystalline quartz, monocrystalline quartz has a more stable microstructure and is mechanically stronger. The macro-mechanical properties of tight sandstone samples are weakened by increased microstructural inhomogeneity and larger grain size. This leads to a higher likelihood of splitting damage, characterized by a high degree of discrete and weak stress sensitivity. The major conclusion is that the positive rhythm lithofacies of medium-grained sandstone to siltstone are the most favorable for efficient CO2 sequestration in deep unmineable coal seams.
Adverse drug reactions and events in an Ageing PopulaTion risk Prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients
Authors: Frydenlund Juliane , Cosgrave Nicole , Moriarty Frank , Wallace Emma , Kirke Ciara , Williams David J. , Bennett Kathleen , Cahir Caitriona 
Published: January 2025

Abstract

Purpose
Older people are at an increased risk of developing adverse drug reactions (ADR) and adverse drug events (ADE). This study aimed to develop and validate a risk prediction model (ADAPTiP) for ADR/ADE in older populations.

Methods
We used the adverse drug reactions in an Ageing PopulaTion (ADAPT) cohort (N = 798; 361 ADR-related admissions; 437 non-ADR-related admissions), a cross-sectional study designed to examine the prevalence and risk factors for ADR-related hospital admissions in patients aged ≥ 65 years. Twenty predictors (categorised as sociodemographic-related, functional ability-related, disease-related, and medication-related) were considered in the development of the model. The model was developed using multivariable logistic regression and was internally validated by fivefold cross-validation. The model was externally validated in a separate prospective cohort from the Centre for Primary Care Research (CPCR) study of ADES. The cross-validated and externally validated model performance was evaluated by discrimination and calibration.

Results
The final prediction model, ADAPTiP, included nine predictors: age, chronic lung disease, the primary presenting complaints of respiratory, bleeding and gastrointestinal disorders and syncope on hospital admission and antithrombotics, diuretics, and renin–angiotensin–aldosterone system drug classes. ADAPTiP demonstrated good performance with cross-validated area under the curve of 0.75 [95% CI 0.72;79] and 0.83 [95% CI 0.80;0.87] in the external validation.

Conclusion
Using accessible information from medical records, ADAPTiP can help clinicians to identify those older people at risk of an ADR/ADE who should be monitored and/or have their medications reviewed to avoid potentially harmful prescribing.
Robust successive generalised dynamic inversion control of satellite launch vehicles
Authors: Bajodah A.H. , Ansari U. 
Published: January 2025

ABSTRACT
In this paper, we designa robust Successive Generalised Dynamic Inversion (SGDI) flight control system for high-performance trajectory tracking of target sun-synchronous orbit Satellite Launch Vehicles (SLVs). The robust SGDI control system is designed to track an optimal reference trajectory such that the desired orbital terminal conditions of the ascent flight phase are achieved. The proposed SGDI is composed of two loops. The attitude control loop employs Dynamically Scaled Generalised Inversion (DSGI) of Servo Constraint Dynamics (SVD) in the deviations of Euler attitude angles from their desired optimal trajectories. The inner-dynamics control loop employs DSGI of an SVD in the SLV angular velocity components. Robustification control elements are augmented within the two loops of the baseline SGDI control system to overcome control performance degradation due to dynamic scaling of the Moore-Penrose generalised inverse, modeling and parametric uncertainties, and exogenous disturbances. The robust SGDI control system works to enforce global convergence of the SLV attitude trajectories to the reference trajectories. The high-performance attributes of the robust SGDI control system are verified via comparisons with a classical sliding mode control system, and by performing numerous runs of Monte Carlo simulations under various types of uncertainties and external wind disturbances.
Anthropogenic factors, not altitude, shape native and nonnative plant species distributional patterns in a tropical mountain protected area
Authors: da Rosa Hugo Henrique Marques , Silveira Raphaela Aparecida Duarte , Oliveira Beatriz Cunha Mello , Heringer Gustavo , Zenni Rafael Dudeque 
Published: January 2025

AbstractBiological invasions pose a major threat to biodiversity conservation in protected areas, with roads, tracks, and trails being the main pathways for the spread of non-native species. This study aimed to assess the distribution patterns of non-native and native plant species in relation to elevational gradient, public use intensity, and disturbance by roads and trails in a protected tropical mountain forest in southeastern Brazil. Specifically, we recorded plant species along this gradient and tested whether the richness of native and non-native species differed with elevation. Additionally, we investigated whether the high-altitude non-native species community was a subset of lower-elevation communities and whether non-native species richness was linked to anthropogenic disturbances and public use intensity. Our findings revealed that native and non-native species richness varied along the elevational gradient. Native species exhibited a hump-shaped pattern, with richness peaking at mid-elevations. In contrast, non-native species did not show a clear trend along the altitudinal gradient. Notably, higher non-native species richness was observed in roadside and trailside plots. The non-native species communities at higher altitudes were not simply subsets of those found at lower elevations. Thus, while the richness and composition of native species appeared to be driven by environmental factors along the elevational gradient, the presence of non-native species was more closely associated with anthropogenic disturbances. In summary, our results indicate that non-native plants, although widespread along trails and roads, establish primarily in the most disturbed areas. Therefore, roads, trails, and human and vehicular traffic are key determinants of biological invasions in this mountainous protected area.
The Italian general psychiatry and forensic psychiatry treatment model: a unique story
Authors: Carabellese Felice F. , Parente Lia 
Published: January 2025

Abstract
The history of Italian general psychiatry and forensic psychiatry over the last 50 years has been unique in the European and Western healthcare landscape. Western politicians often visit Italy to observe the successful community-based systems that have developed in that country.
This article represents a first step toward a necessary attempt, to explore how specific political decisions, such as the Italian one, have produced positive outcomes for patients with psychotic disorders, outcomes not observed in many Western countries, which are instead grappling with negative outcomes such as the complicated management of homelessness and the incarceration of people who would instead require psychiatric care.
In its historical context, the 1978 decision to abandon the asylum tradition in favor of socialization for patients living with severe mental disorders represented a difficult choice. This choice led to inevitable critical issues, which today are still not completely dormant.
This choice has also, undoubtedly, restored dignity to people living with serious mental illness, even when that person commits a crime.
To understand these changes, it is appropriate to mention the regulations that finally led to Law number 180 of 1978, which decreed the closure of psychiatric hospitals (Ospedale Psichiatrico) throughout Italy and continued after 2015 with the closure of high-security psychiatric hospitals (Ospedale Psichiatrico Giudiziario) as well.
Culturally, much has changed throughout this time in assistance to the mentally ill in Europe.
Permafrost and Structural Controls on Holocene Bedrock Landslide Occurrence Around Eyjafjörður, North‐Central Iceland
Authors: Booth Adam M. , Pétursson Halldór G. 
Published: January 2025

AbstractRapid, transient, landscape‐scale changes associated with deglaciation can condition slopes for failure and trigger bedrock landslides. However, the mechanisms leading to paleo rock slope failures following the last glacial period are challenging to infer because observations of how both landsliding and potential driving factors were distributed in space and time are limited. Here, we map and analyze the spatiotemporal pattern of 676 post‐glacial bedrock landslides around Eyjafjörður in north‐central Iceland using 2‐m resolution digital elevation data generated from optical stereo satellite imagery. Frequency‐ratio analysis demonstrates that after controlling for slope, landslides are most overrepresented within 2.6 km horizontal distances from surface projections of major Tertiary bedrock structures and at land surface elevations within 300 m of a modeled lower limit to permafrost. Surface roughness analysis of landslide deposits indicates that peak landslide frequency of at least 0.2 landslides yr−1 in the 5,579 km2 study area lagged deglaciation by several thousand years. This timing aligns well with that of rapid permafrost degradation from the Younger Dryas (12.9–11.7 cal ky BP) through the Holocene Thermal Maximum (∼10–7 cal ky BP). Landslide frequency has averaged about 0.014 landslides yr−1 since the Holocene Thermal Maximum when the climate has generally been cooler and permafrost has been more extensive. However, present day warming is likely to reduce permafrost extent and increase the potential for bedrock landslides in north‐central Iceland, as has already been observed for several recent shallower landslides in regolith.
Uncertainties in Simulating Flooding During Hurricane Harvey Using 2D Shallow Water Equations
Authors: Xu Donghui , Bisht Gautam , Engwirda Darren , Feng Dongyu , Tan Zeli , Ivanov Valeriy Y. 
Published: January 2025

AbstractFlooding is one of the most impactful weather‐related natural hazards. Numerical models that solve the two dimensional (2D) shallow water equations (SWE) represent the first‐principles approach to simulate all types of spatial flooding, such as pluvial, fluvial, and coastal flooding, and their compound dynamics. High spatial resolution (e.g., () m) is needed in 2D SWE simulations to capture flood dynamics accurately, resulting in formidable computational challenges. Thus, relatively coarser spatial resolutions are used for large‐scale simulations of flooding, which introduce uncertainties in the results. It is unclear how the uncertainty associated with the model resolution compares to the uncertainties in precipitation data sets and assumptions regarding boundary conditions when channelized flows interact with other water bodies. In this study, we compare these three sources of uncertainties in 2D SWE simulations for the 2017 Houston flooding event. Our results show that precipitation uncertainty and mesh resolution have more significant impacts on the simulated streamflow and inundation dynamics than the choice of the downstream boundary condition at the watershed outlet. We point out the viability to confine the uncertainty of coarsening mesh resolution by using the variable resolution mesh (VRM) which refines critical topographic features with far fewer grid cells. Specifically, in simulations with VRM, the simulated inundation depths over the refined region are comparable to that use the finest uniform mesh. This study contributes to understanding the challenges and pathways for applying 2D SWE models to improve the realism of flood simulations over large scales.
CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions
Authors: Huang Lei , Wen Yalei , Guo Qin , Zhang Caishi , Yang Xiao , Li Mei , Liu YiXia , Li Xinying , Tang Jiaxin , Zhou Xiaofeng , Qi Qi , Zhang Haoxing , Liu Tongzheng 
Published: January 2025

Abstract
The aberrant upregulation of Yes-associated protein 1 (YAP1) in a variety of solid cancers contributes to tumor progression and poor clinical outcomes, rendering it an appealing therapeutic target. However, effective therapies to directly target YAP1 remain challenging. In this study, we perform a high-throughput screening and identify Casein kinase II (CK2) as an uncharacterized upstream regulator of YAP1 turnover in cancer cells of ovarian cancer and several other cancer types. Pharmacological inhibition of Casein kinase II by Silmitasertib or genetic depletion of the catalytic subunit of Casein kinase II (CK2α) markedly destabilizes YAP1 and consequently suppresses its oncogenic functions in vitro and in vivo. Moreover, we reveal that DUB3 as a bona fide deubiquitinase of YAP1, which functionally links CK2 and YAP1 stability in a variety of human cancers. Mechanistically, CK2α directly phosphorylates DUB3 at Thr495, thereby facilitating DUB3-mediated deubiquitination process of YAP1. On the contrary, the loss of Thr495 phosphorylation by the phosphorylation-defective mutant DUB3 T495A, the cancer-related mutant DUB3 D496H and CK2 inhibition failed to deubiquitinate and stabilize YAP1 effectively. Notably, upregulated expressions of CK2α and DUB3 in ovarian cancer positively correlate with YAP1 overexpression. Collectively, our findings demonstrate the functional significance of the CK2α-DUB3 axis in YAP1 stabilization and YAP1-driven tumor progression, highlighting that strategies to target this axis might be of benefit in the clinical management of ovarian cancer and several other lethal cancers with aberrantly upregulated YAP1.
Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology
Authors: Ou Shengming , Nie Xiaoya , Qiu Xiangyu , Jin Xin , Wu Geyan , Zhang Rongxin , Zhu Jinrong 
Published: January 2025

Abstract
A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced by changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group of functional RNA molecules that are not translated into proteins, which can regulate gene expression in various manners. An increasing number of studies have shown that lncRNAs can interfere with the progression of ferroptosis by modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating lncRNAs in cancer and inflammation, studies on their mechanisms and therapeutic potential remain scarce. We investigate the mechanisms of lncRNA-mediated regulation of inflammation and cancer immunity, assessing the feasibility and challenges of lncRNAs as therapeutic targets in these conditions.
Design of organic crystals with lone pairs to study spin resonance and spin-lattice interactions
Authors: Li Shilin , Lu Xiangqian , Qin Wei 
Published: January 2025

Abstract
Lone pairs are widely prevalent in various types of molecules and have a significant impact on the band structure, carrier transport, and dielectric response, which are the key factors for exploring the underlying mechanism of phenomena in opto-spintronics. In this work, nitrogen substitutions with nonequivalent hybridization are adopted to obtain different types of organic charge transfer crystals, where lone pairs are generated to weaken the interactions between donors and acceptors, resulting in a blueshift in photoluminescence and a weaker electron-lattice coupling. Moreover, lone pairs could further strengthen the ability to transfer energy and spin angular momentum to the lattice vibration to enhance spin resonance. Additionally, due to the effect of lone pairs, the spin density inside the crystals is redistributed to tune the transition between the singlet and triplet states. Overall, crystals with lone pairs demonstrate a more diverse set of magnetic, optical, and spin-related properties.
Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice
Authors: Nielsen Hailyn V. , Yang Letitia , Mueller James L. , Ritter Alexander J. , Hiwa Ryosuke , Proekt Irina , Rackaityte Elze , Aylard Dominik , Gupta Mansi , Scharer Christopher D. , Anderson Mark S. , Au-Yeung Byron B. , Zikherman Julie 
Published: January 2025

Abstract
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the mechanisms by which they operate are not clear. Moreover, their role in central tolerance is obscured by redundancy among the Nr4a family members and by their reported functions in Treg generation and maintenance. Here we take advantage of competitive bone marrow chimeras and the OT-II/RIPmOVA model to show that Nr4a1 and Nr4a3 are essential for the upregulation of Bcl2l11/BIM and thymic clonal deletion by self-antigen. Importantly, thymocytes lacking Nr4a1/3 acquire an anergy-like signature after escaping clonal deletion and Treg lineage diversion. We further show that the Nr4a family helps mediate a broad transcriptional program in self-reactive thymocytes that resembles anergy and may operate at the margins of canonical thymic tolerance mechanisms to restrain self-reactive T cells after thymic egress.
Preference for and resistance to a toxic sulfur volatile opens up a unique niche in Drosophila busckii
Authors: Pal Mahadevan Venkatesh , Galagovsky Diego , Knaden Markus , Hansson Bill S. 
Published: January 2025

Abstract
The ability to tolerate otherwise toxic compounds can open up unique niches in nature. Among drosophilid flies, few examples of such adaptations are known and those which are known are typically from highly host-specific species. Here we show that the human commensal species Drosophila busckii uses dimethyldisulfide (DMDS) as a key mediator in its host selection. Despite DMDS’s neurotoxic properties, D. busckii has evolved tolerance towards high concentrations and uses the compound as an olfactory cue to pinpoint food and oviposition sites. This adaptability is likely linked to insensitivity of the enzyme complex cytochrome c oxidase (COX), which is a DMDS target in other insects. Our findings position D. busckii as a potential model for studying resistance to toxic gases affecting COX and offers insight into evolutionary adaptations within specific ecological contexts.