bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating high power laser therapy (HPLT) as treatment for chemotherapy‐induced oral mucositis in paediatric patients with oncohematological diseases
Authors: Ludovichetti Francesco Saverio , Costa Giorgia , Signoriello Anna Giulia , Stellini Edoardo , Zerman Nicoletta , Biffi Alessandra , Mazzoleni Sergio 
Published: January 2023

AbstractBackgroundOral mucositis (OM) is one of the most debilitating side effects of chemotherapy. Among the current methods used in OM management, the feasibility of high power laser therapy (HPLT) has been proposed but not fully evaluated.AimThe aim of this study was to evaluate the efficacy of HPLT in the treatment of OM in paediatric patients.DesignFourteen oncohematological paediatric patients treated with chemotherapy and/or hematopoietic stem cell transplantation and affected by OM at different grades were enrolled in this study. All patients were treated with a class IV laser device in four sessions for four consecutive days, OM was evaluated with the WHO‐OTS scale. The perception of pain was assessed by the visual analog scale. Photographs of and information about lesions and patient questionnaires were taken and collected, respectively. Descriptive analyses and the Wilcoxon signed‐rank test (nonparametric test) were used, with a statistical significance of α = .05.ResultsAfter a week into the treatment, 57% of patients were completely healed, whereas the whole cohort experienced a drastic decrease in pain, from an average value of 5.8–1.1 (p = .0016). The average number of injuries per patient decreased from 7.4 to 3.1 (p = .008).ConclusionHigh power laser therapy appears to be a safe and efficacious method for managing OM. It reduces pain and severity of oral cavity injuries. Further studies are needed to determine the optimal parameters useful in OM treatment and to evaluate the relative effectiveness of HPLT to other treatments like LLLT.
High‐temperature oxidation of BN‐coated sylramic SiC fibers in dry and wet atmosphere
Authors: Avincola Valentina Angelici , Opila Elizabeth 
Published: January 2023

AbstractThe oxidation behavior of SiC Sylramic fibers coated with chemically vapor deposited Si‐doped boron nitride (BN) was investigated at temperatures between 800 and 1200°C in dry and wet O2atmospheres. Thermogravimetric analysis was used to study the oxidation kinetics of the fiber and the influence of the BN layer and the environment. The morphology and composition of the thermally grown oxide scale was determined posttest by scanning electron microscopy, X‐ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectrometry. This study gives new insights into the synergistic effects of BN and water vapor on the oxidation behavior SiC Sylramic fibers. The vulnerability of the BN fiber interphase and the behavior of the fiber under conditions relevant to high‐temperature turbine applications are discussed.
Hydrolysis‐induced simultaneous foaming and coagulation casting of secondary aluminum dross aqueous suspension
Authors: Li Wenhao , Zhang Xiaoyan , Shen Hanlin , Yang Junjie , Liu Ying , Liu Jun , Qu Ya‐Nan , Zhang Shengen , Yang Jinlong 
Published: January 2023

AbstractThe reactive AlN, heavy metal ions, and salts in secondary aluminum dross make them harmful to the environment and difficult to handle, and therefore categorized as hazardous solid waste. A novel, simple, and versatile technique has been proposed here to prepare hierarchically porous ceramics using secondary aluminum dross as the sole raw material, namely, the hydrolysis‐induced simultaneous foaming and coagulation casting method. As the main component, Al and AlN could be hydrolyzed to generate aluminum hydroxide sol, which can form three‐dimensional network and lead to the outstanding compressive strength of green body (7.03 MPa). Gas release during hydrolysis, high‐temperature oxidation of AlN, and metallic Al based on Kirkendall effect could account for the final multilevel pores. The utilization of harmful components in secondary aluminum dross, supplys an alternative colloidal forming way for porous green body with complex shape when combined with other ceramic powders or inorganic solid waste. Low sintering shrinkage of 1.38%–3.60% for hierarchically porous ceramics offers this highly effective and low‐cost method to be easily promoted for industrial production.
Giant dielectric response and grain heterogeneity of Y2/3Cu3Ti4O12–TiO2 composite ceramics fabricated by hydrothermal process
Authors: Tan Junlang , Guo Yong , Ren Futong , Zhao Jingchang 
Published: January 2023

AbstractDue to the boom of the electronic information industry, dielectric ceramic materials are widely applied in passive components such as multilayer ceramic capacitors. In this article, Y2/3Cu3Ti4O12–TiO2 composite ceramics with outstanding dielectric properties (εr = 2.29 × 106 at 20 Hz, εr = 4.49×105 at 1 kHz) were successfully prepared by hydrothermal and in situ solid‐state methods. The minimum dielectric loss value (at 1 kHz) of the obtained composite ceramics is about 0.57. The experimental results show that Y2/3Cu3Ti4O12 has a composite perovskite structure with cation vacancies, which causes internal electron‐pinned defect‐dipole, and the easy entry of excessive titanium ions to produce donor defects. Meanwhile, the heterogeneous grains with a pomegranate‐like microstructure were observed in the prepared composite ceramics, and interfacial polarization between subgrain boundaries was substantiated by impedance analysis. The abundant weakly trapped electrons and more polarized interfaces formed by grain and subgrain boundaries are the primary sources of the excellent dielectric properties of composite ceramics.
The efficacy of non‐surgical platelet‐rich fibrin application on clinical periodontal parameters and periostin level in periodontitis: Clinical trial
Authors: Al‐Rihaymee Sarah , Sh. Mahmood Maha 
Published: January 2023

AbstractPlatelet‐rich fibrin (PRF) has been widely used in regenerative dentistry due to many growth factors produced. Periostin, a matricellular protein, is a reliable marker for tissue regeneration. Periostin is part of the cellular matrix and regulates bone homeostasis. This study aims to explore the efficacy of PRF in improvement of the clinical periodontal parameters as an adjunct to the scaling and root planing and to evaluate periostin level in gingival crevicular fluid (GCF) at baseline, 1‐ and 3‐month recall visits. Fourteen periodontitis patients who met the inclusion criteria were recruited in this study. Two contralateral periodontal pockets with 4–6 mm in depth in each patient were selected. The sites in every participant were randomly allocated into control sites or test sites. In control sites, only conventional scaling and root planing was carried out. In test sites, however, scaling and root planing method and PRF were applied. Periostin level in GCF and clinical periodontal parameters were measured. The test sites revealed greater relative attachment gain (2.614 ± 0.606 mm and 3.321 ± 0.668 mm) than control sites (1.285 ± 0.671 mm and 1.839 ± 0.632 mm) and a significant pocket reduction (2.535 ± 0.664 mm and 3.321 ± 0.668 mm) than the control sites (1.21 ± 0.508 mm and 1.892 ± 0.655 mm) at 1‐ and 3‐month recall visits respectively. In the test sites, level of periostin (48.83 ± 9.3 ng/μl and 98.90 ± 24.94 ng/μl) were greater than periostin levels in the control sites (42.65 ± 7.03 ng/μl and 49.29 ± 15.14 ng/μl) at 1‐ and 3‐month recall visits respectively. In conclusion, the non‐surgical application of PRF as an adjunct to scaling and root planing significantly improved the clinical periodontal parameters through raising periostin level in GCF.
Be prepared: Does psychological reattachment buffer the effect of a bad night's sleep on day‐specific work engagement and proactivity?
Authors: Schleupner Ricarda M. , Kühnel Jana , Melchers Klaus G. , Richter Selina S. 
Published: January 2023

AbstractPsychological reattachment means mentally tuning into one's work before starting work in the morning. In this daily diary study, we investigated whether psychological reattachment may be beneficial not only for work engagement but also for proactivity during the day. We moreover considered two competing theoretical propositions regarding the role of psychological reattachment in the effect of sleep quality on work engagement and proactivity. The first proposition assumes a cognitive, self‐regulatory perspective in which psychological reattachment serves as a moderator, buffering the detrimental effect of poor sleep quality on work engagement and proactivity. The second proposition assumes an energetic process in which psychological reattachment may benefit from a good night's sleep and thus serve as a mediator for the beneficial effect of sleep quality on work engagement and proactivity. We conducted a daily diary study over ten consecutive workdays. Altogether, we collected data from 171 employees on 1186 days. The results indicated that on days with good sleep quality and higher psychological reattachment, work engagement and proactivity were higher. Day‐specific psychological reattachment buffered the negative effects of a poor night's sleep on work engagement, supporting the first of our competing hypotheses. Finally, we present ideas on how to foster psychological reattachment in practice.
Immune infiltration and diagnostic value of immune‐related genes in periodontitis using bioinformatics analysis
Authors: Lai Donglin , Ma Wenhao , Wang Jie , Zhang Luzhu , Shi Junfeng , Lu Changlian , Gu Xuefeng 
Published: January 2023

AbstractBackground and ObjectivesPeriodontitis, which is a chronic inflammatory periodontal disease resulting in destroyed periodontal tissue, is the leading cause of tooth loss in adults. Many studies have found that inflammatory immune responses are involved in the risk of periodontal tissue damage. Therefore, we analyzed the association between immunity and periodontitis using bioinformatics methods to further understand this disease.Materials and MethodsFirst, the expression profiles of periodontitis and healthy samples were downloaded from the GEO database, including a training dataset GSE16134 and an external validation dataset GSE10334. Then, differentially expressed genes were identified using the limma package. Subsequently, immune cell infiltration was calculated by using the CIBERSORT algorithm. We further identified genes linking periodontitis and immunity from the ImmPort and DisGeNet databases. In addition, some of them were selected to construct a diagnostic model via a logistic stepwise regression analysis.Results and ConclusionsTwo hundred sixty differentially expressed genes were identified and found to be involved in responses to bacterial and immune‐related processes. Subsequently, immune cell infiltration analysis demonstrates significant differences in the abundance of most immune cells between periodontitis and healthy samples, especially in plasma cells. These results suggested that immunity doses play a non‐negligible role in periodontitis. Twenty‐one genes linking periodontitis and immunity were further identified. And nine hub genes of them were identified that may be key genes involved in the development of periodontitis. Gene ontology analyses showed that these genes are involved in response to molecules of bacterial origin, cell chemotaxis, and response to chemokines. In addition, three genes of them were selected to construct a diagnostic model. And its good diagnostic performance was demonstrated by the receiver operating characteristic curves, with an area under the curve of 0.9424 for the training dataset and 0.9244 for the external validation dataset.
The plasma and tissue kinetics of sulfadiazine and its metabolite in Ictalurus punctatus after oral gavage at two temperatures
Authors: Xu Ning , Cheng Bo , Yang Yibin , Liu Yongtao , Dong Jing , Yang Qiuhong , Zhou Shun , Song Yi , Ai Xiaohui 
Published: January 2023

AbstractA plasma and tissue kinetic study of sulfadiazine (SDZ) and its metabolite, N4‐acetyl sulfadiazine (ACT‐SDZ), was characterized in channel catfish (Ictalurus punctatus) following a single oral dose of 50 mg/kg at 18 and 24°C. Samples were collected at predetermined time points and determined by ultra‐performance liquid chromatography. The classical one‐compartmental method was used to estimate the pharmacokinetic parameters. Results showed that the changing of temperature was markedly influential on the kinetics of SDZ and ACT‐SDZ in plasma and tissues. When the temperature was increased from 18 to 24°C, the elimination half‐life (K10_HF) of SDZ was decreased in gill, kidney, and muscle + skin, but increased in liver and plasma. The K10_HF of ACT‐SDZ also had a decreased trend in gill, liver, and plasma but had comparable values in kidney and muscle + skin. The absorption half‐life (K01_HF), time to peak concentration (Tmax), and area under concentration–time curve (AUC0‐∞) of SDZ and ACT‐SDZ all exhibited declined tendencies in plasma and tissues. The apparent volume of distribution (V_F) of SDZ in plasma was increased from 0.53 to 1.48 L/kg, and the apparent systemic total body clearance (Cl_F) was increased from 0.028 to 0.060 L/h/kg. In a word, K01_HF, Tmax, and AUC0‐∞ of SDZ and ACT‐SDZ were decreased in plasma and tissues with the increase of temperature, whereas the V_F and Cl_F of SDZ were increased. Meanwhile, we calculated the percentage of time profile of SDZ concentration more than minimum inhibitory concentration to total time (%T > MIC) to guide clinical usage of SDZ. When the dosage interval was 24 h, the values of %T > MIC were all >90% in plasma and most tissues. Therefore, we recommend an oral dose of SDZ at 50 mg/kg once per 24 h at 18–24°C against the fish pathogens with an MIC value of ≤6.4 μg/mL.
Effects of starvation on the pharmacokinetics and optimal dosages of florfenicol and associated serum biochemistry in Asian seabass (Lates calcarifer)
Authors: Rairat Tirawat , Hsieh Ming‐Kun , Lu Yi‐Ping , Ho Wan‐Cih , Wu Ho‐Chien , Chou Chi‐Chung 
Published: January 2023

AbstractStarvation has influence on physiology and pharmacokinetic (PK) characteristics of many drugs in land animals. However, similar PK information in fish is lacking. The current study examined the effects of starvation on fish PK, taking florfenicol (FF) in Asian seabass as an example. FF was orally administered at a single dose of 10 mg/kg into 35‐day starved fish reared at 25 and 30°C and the serum FF concentration was analyzed by HPLC‐FLD. At 30°C, the absorption and elimination half‐lives of the starved fish were increased by 30% (from 0.44 to 0.57 h) and 55% (from 7.2 to 11.18 h), respectively. The volume of distribution, clearance, and area under the curve were changed from 1.25 to 0.71 L/kg, 0.120 to 0.044 L/kg/h, and 88 to 228 h·μg/ml, respectively. Similar starvation‐induced PK changes were also observed at 25°C. The serum biochemical parameters, mainly the alanine aminotransferase, aspartate aminotransferase, and glucose levels, were significantly reduced in the starvation group. Overall, FF absorption, distribution, and elimination rates were reduced by starvation, resulting in four to five times lower optimal dosage than the non‐starved fish. Drug treatment in starved fish should be treated with caution as overdosing and/or tissue residues could perceivably occur.
Perceptions of intimate partner stalking and cyberstalking: Do perpetrator and victim gender and victims' responses to stalking influence perceptions of criminal behaviour and responsibility?
Authors: Gordon Daniel L. , Dardis Christina M. 
Published: January 2023

AbstractPurposeWhile the gender of stalking victims and perpetrators may affect perceptions of stalking, limited research has examined whether victim responses to stalking (i.e. ignoring or confronting the perpetrator) are similarly influential. The present study examined whether perpetrator and victim gender and victim response (ignore vs. asking the perpetrator to stop) were related to perceptions of stalking and cyberstalking.MethodsParticipants (N = 223) from the United States were randomly assigned to one of four vignettes (gender × victim response) that included both in‐person stalking and cyberstalking behaviours. Perceptions assessed included: whether police intervention was necessary, whether the scenario constituted a crime, and how responsible the perpetrator and victim were for the situation. They also rated how distressing they believed the in‐person (vs. cyberstalking) behaviours would be.ResultsMost of the participants believed police intervention was required (57.4%), yet fewer believed a crime occurred (32.7%). Overall, in‐person stalking behaviours were seen as more distressing than were cyberstalking behaviours. Men were perceived as more responsible than women when they were both victims and perpetrators. There was an interaction between gender and victim response to stalking, such that male victims who ignored the perpetrator were considered less in need of police intervention than female victims who ignored the perpetrator (and male and female victims who confronted the perpetrator).ConclusionsBoth male victims and perpetrators may be perceived as more responsible by juries and informal supports. Men may be viewed as less in need of law enforcement support unless they have already confronted their pursuer.
Second‐Personal Approaches to Moral Obligation
Authors: Schaab Janis David 
Published: January 2023

AbstractAccording to second‐personal approaches to moral obligation, the distinctive normative features of moral obligation can only be explained in terms of second‐personal relations, i.e. the distinctive way persons relate to each other as persons. But there are important disagreements between different groups of second‐personal approaches. Most notably, they disagree about the nature of second‐personal relations, which has consequences for the nature of the obligations that they purport to explain. This article aims to distinguish these groups from each other, highlight their respective advantages and disadvantages, and thereby indicate avenues for future research.
Assessing potential hybridization between a hypothetical gene drive‐modified Drosophila suzukii and nontarget Drosophila species
Authors: Wolf Sarah , Collatz Jana , Enkerli Jürg , Widmer Franco , Romeis Jörg 
Published: January 2023

AbstractGenetically engineered gene drives (geGD) are potentially powerful tools for suppressing or even eradicating populations of pest insects. Before living geGD insects can be released into the environment, they must pass an environmental risk assessment to ensure that their release will not cause unacceptable harm to non‐targeted entities of the environment. A key research question concerns the likelihood that nontarget species will acquire the functional GD elements; such acquisition could lead to reduced abundance or loss of those species and to a disruption of the ecosystem services they provide. The main route for gene flow is through hybridization between the geGD insect strain and closely related species that co‐occur in the area of release and its expected dispersal. Using the invasive spotted‐wing drosophila, Drosophila suzukii, as a case study, we provide a generally applicable strategy on how a combination of interspecific hybridization experiments, behavioral observations, and molecular genetic analyses can be used to assess the potential for hybridization.
Trans‐local action and local climate policy. Configurations of success for climate innovations in the European multilevel system
Authors: Corcaci Andreas , Kemmerzell Jörg 
Published: January 2023

AbstractLocal climate policy in Germany is embedded in a complex and dense multilevel system. While higher levels of governance confront cities with legal frameworks and regulations, they are not constrained to mere implementation of requirements from the national or supranational levels. Cities can influence and make strategic use of opportunities stemming from the multilevel structure to introduce innovative climate policy measures as best practices. Within a multilevel structure, they can engage in trans‐local action and become actors in various processes of upscaling. In this paper, we analyze the configurations of success for local climate innovations. We focus on the impact of cities' trans‐local and strategic activities within the European multilevel system in conjunction with city‐specific context conditions. The research is based on a concept‐structural framework that combines trans‐local activities and internal context conditions in a way that accounts for interactions between the two spheres. A comparison of the German cities of Darmstadt, Hagen, Offenbach, and Oldenburg indicates that configurations of strategic action in the multilevel system and beneficial local conditions explain the adoption of climate innovations. Therefore, such trans‐local action should not be understood as a sufficient condition of innovative climate policy measures, but as an enabling factor embedded in local contexts.
Current oral health services and the divergent needs of the baby boom cohorts
Authors: Rawal Kadambari , Calabrese Joseph 
Published: January 2023

AbstractThe two cohorts of Baby Boomers, the Early (born between 1945 and 1955) and the Late (born between 1956 and 1964), have some subtle yet distinct differences when it comes to their oral health and oral health related behaviors. Unlike their predecessors, the Baby Boomer cohorts are retaining more teeth, as there is a sharp fall in edentulous rates in this population. The oral health care community is now facing unparalleled challenges in providing and maintaining the oral health of this unique cohort who are keeping their teeth longer, have multiple comorbidities, and are living longer than previous generations. This paper draws from the latest studies, scientific data and research to describe a realistic picture of the oral health services available to and utilized by the Baby Boomers. The factors affecting utilization, their rising needs, demands, expectations, and areas where improvement is needed for the Baby Boomer are also reported here.
Impact of social phone programs on loneliness and mood in older adults: a mixed methods systematic review protocol
Authors: Nelson Heather , Langman Erin , Hubbard Murdoch Natasha , Ziefflie Beverlee , Mayer Paula , Page Susan , Fuchs-Lacelle Shannon , Norton Deborah 
Published: January 2023

Objective:
The objective of this mixed methods review is to examine the effectiveness and experience of social phone programs on loneliness and/or mood in community-dwelling older adults.

Introduction:
There is a large and growing older adult population that is burdened with loneliness. Loneliness affects both physical and mental health, and it is, therefore, imperative to examine ways of mitigating experiences of loneliness. Social phone programs are being offered through multiple organizations as a way of increasing socialization and decreasing loneliness in older adults. There is a need to examine existing data on social phone programs to determine their effectiveness and optimize their implementation.

Inclusion Criteria:
Included studies will be original qualitative, quantitative, or mixed methods research, along with gray literature, examining the use of social phone programs to address loneliness and/or mood in older adults.

Methods:
A convergent segregated mixed methods approach will be used, in line with the JBI methodology for mixed methods reviews. Articles will be searched in selected databases, sources of clinical trials, and gray literature. No limits have been set for language or date of publication. Two team members will select studies through title and abstract screening and then full-text screening. Critical appraisal will be performed in accordance with the standard JBI critical assessment tools, although no articles will be excluded based on this appraisal. Quantitative articles will be synthesized using meta-analysis, while a process of meta-aggregation will be used for qualitative articles. The findings will be integrated into a final report.

Systematic review registration number:
CRD42022335119