bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
Authors: Chałubińska-Fendler Justyna , Nowicka Zuzanna , Dróżdż Izabela , Graczyk Łukasz , Piotrowski Grzegorz , Tomasik Bartłomiej , Spych Michał , Fijuth Jacek , Papis-Ubych Anna , Kędzierawski Piotr , Kozono David , Fendler Wojciech 
Published: May 2023

IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
Automatic renal mass segmentation and classification on CT images based on 3D U-Net and ResNet algorithms
Authors: Zhao Tongtong , Sun Zhaonan , Guo Ying , Sun Yumeng , Zhang Yaofeng , Wang Xiaoying 
Published: May 2023

PurposeTo automatically evaluate renal masses in CT images by using a cascade 3D U-Net- and ResNet-based method to accurately segment and classify focal renal lesions.Material and MethodsWe used an institutional dataset comprising 610 CT image series from 490 patients from August 2009 to August 2021 to train and evaluate the proposed method. We first determined the boundaries of the kidneys on the CT images utilizing a 3D U-Net-based method to be used as a region of interest to search for renal mass. An ensemble learning model based on 3D U-Net was then used to detect and segment the masses, followed by a ResNet algorithm for classification. Our algorithm was evaluated with an external validation dataset and kidney tumor segmentation (KiTS21) challenge dataset.ResultsThe algorithm achieved a Dice similarity coefficient (DSC) of 0.99 for bilateral kidney boundary segmentation in the test set. The average DSC for renal mass delineation using the 3D U-Net was 0.75 and 0.83. Our method detected renal masses with recalls of 84.54% and 75.90%. The classification accuracy in the test set was 86.05% for masses (&lt;5 mm) and 91.97% for masses (≥5 mm).ConclusionWe developed a deep learning-based method for fully automated segmentation and classification of renal masses in CT images. Testing of this algorithm showed that it has the capability of accurately localizing and classifying renal masses.
Heterogeneity in clinical prognosis, immune infiltration and molecular characteristics of three glycolytic subtypes in lower-grade gliomas
Authors: Wu Shenglian , Sheng Lulu , Fan Shucai , Guo Xi , Zhu Biao , Wu Cheng , Lei Bing 
Published: May 2023

Background and purposeLower-grade gliomas (LGG) exhibit a wide range of metabolic pathway changes, and metabolic reprogramming can be largely seen as a result of oncogenic driving events. Glycolysis, an important pathway of tumor energy source, has been poorly studied in gliomas. The aim of this article is to analyze the relationship between glycolysis and lower-grade glioma development and prognosis in order to explore the heterogeneous relevance of glycolysis in lower-grade gliomas.Methods and resultsOur study searched the TCGA database and identified three glycolytic subtypes with significant prognostic differences by unsupervised clustering analysis of core glycolytic genes, named C1, C2, and C3. By analysis of clinical prognosis, somatic cell variation, and immune infiltration, we found that C3 had the best prognosis with molecular features of IDHmut-codel, followed by C1 with major molecular features of IDHmut-non-codel, G -CIMP high subtype, while C2 had the worst prognosis, mainly exhibiting IDHwt, G-CIMP low and mesenchymal-like subtypes with seven important CNV features, including CDKN2A/B deletion, chr7 gain and chr10 deletion, chr19/20 co-gain, EGFR amplification and PDGFRA/B deletion phenotypes were significantly increased, with the highest level of stemness and significant T-cell depletion features. Finally, to quantify the level of abnormal glycolysis and its impact on prognosis, we developed GlySig to reflect the glycolytic activity of LGG and integrated molecular features to construct nomogram that can be independently assessed to predict prognosis.ConclusionsOur study analyzed the tumor characteristics of different glycolytic states, and our findings explain and describe the heterogeneity of glycolytic metabolism within diffuse LGGs.
Characteristics and outcomes of multisystem inflammatory syndrome in children: A multicenter, retrospective, observational cohort study in Mexico
Authors: Yamazaki-Nakashimada Marco Antonio , Márquez-González Horacio , Miranda-Novales Guadalupe , Neme Díaz Gonzalo Antonio , Prado Duran Sandhi Anel , Luévanos Velázquez Antonio , Castilla-Peon Maria F. , González-García Nadia , Sánchez Duran Miguel Alejandro , Márquez Aguirre Martha Patricia , Villasis-Keever Miguel Angel , Aragón Nogales Ranferi , Núñez-Enríquez Juan Carlos , Martinez Bustamante Maria Elena , Aguilar Argüello Carlos , Ramírez de los Santos Jesús , Pérez Barrera Alejandra , Palacios Cantú Lourdes Anais , Membrila Mondragón Jesús , Vizcarra Alvarado Paloma , Jiménez Juárez Rodolfo Norberto , Olivar López Víctor , Velasco-Segura Roberto , López Chávez Adrián 
Published: May 2023

IntroductionMultisystem inflammatory syndrome in children associated with coronavirus disease 2019 (MIS-C), a novel hyperinflammatory condition secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with severe outcomes such as coronary artery aneurysm and death.MethodsThis multicenter, retrospective, observational cohort study including eight centers in Mexico, aimed to describe the clinical characteristics and outcomes of patients with MIS-C. Patient data were evaluated using latent class analysis (LCA) to categorize patients into three phenotypes: toxic shock syndrome-like (TSSL)-MIS-C, Kawasaki disease-like (KDL)-MIS-C, and nonspecific MIS-C (NS-MIS-C). Risk factors for adverse outcomes were estimated using multilevel mixed-effects logistic regression.ResultsThe study included 239 patients with MIS-C, including 61 (26%), 70 (29%), and 108 (45%) patients in the TSSL-MIS-C, KDL-MIS-C, and NS-MIS-C groups, respectively. Fifty-four percent of the patients were admitted to the intensive care unit, and 42%, 78%, and 41% received intravenous immunoglobulin, systemic glucocorticoids, and anticoagulants, respectively. Coronary artery dilatation and aneurysms were found in 5.7% and 13.2% of the patients in whom coronary artery diameter was measured, respectively. Any cause in-hospital mortality was 5.4%. Hospitalization after ten days of symptoms was associated with coronary artery abnormalities (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.2–2.0). Age ≥10 years (OR: 5.6, 95% CI: 1.4–2.04), severe underlying condition (OR: 9.3, 95% CI: 2.8–31.0), platelet count &lt;150,000 /mm3 (OR: 4.2, 95% CI: 1.2–14.7), international normalized ratio &gt;1.2 (OR: 3.8, 95% CI: 1.05–13.9), and serum ferritin concentration &gt;1,500 mg/dl at admission (OR: 52, 95% CI: 5.9–463) were risk factors for death.DiscussionMortality in patients with MIS-C was higher than reported in other series, probably because of a high rate of cases with serious underlying diseases.
Occupational stress of physicians and nurses in emergency departments after contracting COVID-19 and its influencing factors: a cross-sectional study
Authors: Lv Chuanzhu , Gan Yong , Feng Jing , Yan Shijiao , He Heyu , Han Xiaotong 
Published: May 2023

BackgroundOccupational stress is one of the major occupational health hazards globally. This study investigated the current situation of and factors influencing the occupational stress of physicians and nurses in emergency departments (EDs) after contracting coronavirus disease (COVID-19).MethodsAn online questionnaire survey was conducted among physicians and nurses in EDs in China between January 5 and 8, 2023. A general descriptive analysis of variables was conducted, the differences in the occupational stress of physicians and nurses in EDs with different characteristics were analyzed using the chi-square test, and factors influencing occupational stress were investigated using generalized ordinal logistic regression.ResultsOf the 1924 physicians and nurses in EDs who contracted COVID-19, 64.71% considered their occupational stress high or very high, with overly intense work as the primary stressor. Those with ≥ 10 years of work tenure, working in tertiary hospitals and with higher professional titles were more stressed, while females, nurses, those with a master’s degree or higher, and those who continued to work after contracting COVID-19 were less stressed. There were differences in the predictors of occupational stress between physicians and nurses.ConclusionChina’s physicians and nurses in EDs had high occupational stress after contracting COVID-19. Attention should be given to the occupational mental health of physicians and nurses in EDs, and training on the prevention and treatment of COVID-19 infection should be strengthened.
Prevalence of clinical mastitis and its associated risk factors among dairy cattle in mainland China during 1982–2022: a systematic review and meta-analysis
Authors: Chen Shuiyun , Zhang Huiying , Zhai Junjun , Wang Honghai , Chen Xuelong , Qi Yanping 
Published: May 2023

BackgroundBovine mastitis is one of the most common and prevalent diseases affecting dairy cattle worldwide. It adversely affects the quality and quantity of milk production and leads to a significant economic loss for the farmers.MethodsThis article aimed to estimate the prevalence of clinical mastitis (CM) infection in mainland China using a systematic review and meta-analysis. The research reports published during 1983–2022 in English or Chinese from databases (PubMed, Google Scholar, Cochrane Library, Science Direct, Web of Science, VIP Database for Chinese Technical Periodicals (VIP), Chinese National Knowledge Infrastructure (CNKI), and Wan Fang database) were identified after reviewing the relevant scientific literature. Based on our inclusion criteria, this study analyzed the prevalence of CM in 47 published studies prevalence extracted the total number of cattle infected with CM from the available studies, allowing us to estimate the prevalence of CM infection among these in mainland China.ResultsThe pooled prevalence with the 95% CI for the clinical mastitis was 10% (95% CI: 9.00, 12.00). The majority of CM was associated with lactation, parity, and age, with higher prevalence observed in late lactation 15% (95% CI: 11.00, 18.00) and mid-lactation 10% (95% CI: 6.00, 13.00) in comparison to early lactation 8% (95% CI: 5.00, 10.00). The incidence of CM increased significantly with the increase of parity and age, and the highest incidence rates were 19% (95% CI: 15.00, 23.00) and 16% (95% CI: 12.00, 19.00) at parity and age ≥7, respectively. Among the seasons, the highest prevalence of CM infection was found in autumn 9% (95% CI: 2.00, 17.00). Interestingly, no significant effects were evident regarding the influence of quarter on the prevalence of CM.ConclusionThus, estimating the prevalence of CM among cattle in mainland China. through meta-analysis can provide adequate measures to control CM, reduce economic losses, and prevent the spread and transmission of CM in Chinese herds.
PD-1 and PD-L1 expression in rare lung tumors
Authors: Gyulai Marton , Megyesfalvi Zsolt , Reiniger Lilla , Harko Tunde , Ferencz Bence , Karsko Luca , Agocs Laszlo , Fillinger Janos , Dome Balazs , Szallasi Zoltan , Moldvay Judit 
Published: May 2023

Background: Our knowledge is still limited about the characteristics and treatment of rare lung tumors. The aim of our study was to determine programmed cell death ligand-1 (PD-L1) and programmed cell death-1 (PD-1) expression in rare pulmonary tumors to assess the potential role of immunotherapy.Methods: 66 pathologically confirmed rare lung tumors including 26 mucoepidermoid carcinomas (MECs), 27 adenoid cystic carcinomas (ACCs), and 13 tracheobronchial papillomas (TBPs) were collected retrospectively. Immunohistochemical (IHC) staining was performed on formalin fixed paraffin embedded (FFPE) tumor tissues, and PD-L1 expression on tumor cells (TCs) and immune cells (ICs), and PD-1 expression on ICs were determined. The cut off value for positive immunostaining was set at 1% for all markers.Results: PD-L1 expression on TCs was observed in two cases of MEC (7.7%), one case of ACC (3.7%), and was absent in TBP samples. PD-L1 expression on ICs could be demonstrated in nine cases of MEC (34.6%), four cases of ACC (14.8%), and was absent in TBPs. All PD-L1 TC positive tumors were also PD-L1 IC positive. Higher expression level than 5% of PD-L1 TC and/or IC was observed only in one ACC and in two MEC patients. Among them, strong PD-L1 immunopositivity of &gt;50% on TCs and of &gt;10% on ICs could be demonstrated in one MEC sample. PD-L1 expression of ≥1% on ICs was significantly more common in MEC, than in TBP (p &lt; 0.001). In MEC ≥1% PD-L1 TC or IC expressions were significantly more common in patients aged 55 or older, than in younger patients (p = 0.046, and p = 0.01, respectively). PD-1 expression on ICs was found in five cases of MEC (19.2%), four cases of ACC (14.8%), and in two cases of TBP (15.4%). Only one MEC case showed a higher than 5% expression level of PD-1 on ICs.Conclusion: This retrospective study comprehensively demonstrated the rare expression of PD-L1 and PD-1 in pulmonary MEC, ACC, and TBP. However, we found very strong PD-L1 immunopositivity on both TCs and ICs in one MEC sample, which warrants further investigations in a larger cohort.
A população negra no ordenamento jurídico brasileiro - uma relação de direito e racismo que se perpetua até hoje – da Colonia, do Império à Lei das Cotas
Authors: Moraes Luzia Fernanda dos Santos , Cunha Junior Henrique 
Published: May 2023

O estudo do escravismo no campo jurídico ganha uma relevância manifesta, por tratar de um assunto de suma importância para compreendermos a história jurídica do Brasil no que tange à construção de novos paradigmas ao povo negro. O campo do direito e da justiça vem se tornando objeto de investigação histórica, no sentido forte do termo, LARA, 2000, p.11. Com relação ao quadro legal da escravização dos africanos e seus descendentes no Brasil, o silêncio é praticamente completo. Em algumas ocasiões, entretanto, o interesse por um trabalho de compilação e publicação das ordens legais relativas aos escravos africanos no Brasil tem se manifestado. (LARA, p.7). Nosso objetivo é fornecer os passos para que se possa ter conhecimento e compreensão sob a ótica do direito dos diversos dispositivos legais, que se formaram no decorrer dos séculos em torno do escravismo e que serviram para alicerçar a ideia de inferioridade da população negra, através de conceitos legais vigentes no Brasil colônia e Brasil império. Para tratarmos deste artigo, adejaremos pelas obras de André Barreto Campelo, intitulada, Manual Jurídico da Escravidão: Império do Brasil; História, Direito e Escravidão - A Legislação Escravista no Antigo Regime Ibero-Americano de; A escravidão no Brasil, ensaio histórico-jurídico-social Agostinho Marques Perdigão Malheiros, numa profícua e aprofundada pesquisa de outras bibliografias relevantes, donde foram reproduzidos aqui parte destas obras com informações jurídicas pertinentes ao desenvolvimento deste trabalho. Estudar o direito no período colonial e do império do Brasil até nossos dias desperta o interesse por conhecer as perspectivas da sociedade brasileira, na construção uma nação diversificada e plural, descontruindo o eurocentrismo.
A inclusão das tecnologias digitais na escola básica: mudanças no espaço e no tempo de ensinar e aprender da sala de aula para o mundo
Authors: Moreira Regina Gomes da Costa 
Published: May 2023

Discutimos acerca da inclusão das tecnologias digitais da informação e comunicação – TDIC como ferramenta didática no processo de ensino e aprendizagem em tempos e espaços diferenciados. Consideramos que a tecnologia faz parte do contexto atual e deve ser ressignificada em tempo e espaço de sala de aula. Utilizamos como metodologia a pesquisa-ação por ser cunha qualitativo, sem impedir a ação quantitativa no contexto pesquisado. O objetivo geral é analisar os impactos da inclusão das Tecnologias Digitais da Informação e Comunicação (TDIC) na sala de aula do Ensino Fundamental a partir de novo espaço e tempo escolar procurando estabelecer ações que se coadunem com a realidade escolar pesquisada, junto os professores. Com uso de entrevistas procuramos elementos de inclusão das ferramentas digitais na sala de aula como recurso pedagógico. Concluímos que embora os professores reconheçam a importância das TDIC na sala de aula pouco está sendo feito para que de fato elas ocorram em tempos e espaços escolares diferenciados.
Bbioteca: biblioteca cooperativa para promoção do letramento, do desenvolvimento humano, social e da cultura
Authors: Poletti Igor , Dode Luciana Bicca 
Published: May 2023

A leitura é uma atividade essencialmente cultural aprimorada a partir da alfabetização permite a identificação, compreensão, interpretação, criação, comunicação e assimilação de informações contidas em materiais impressos e escritos. As bibliotecas constituem instrumentos de ação cultural assumindo papel relevante para a disseminação e popularização do conhecimento. As bibliotecas capazes de disponibilizar livros de forma democrática reforçam seu papel social e cultural. A Bbioteca é uma ação de extensão pertencente ao projeto unificado Mural G-Biotec, do curso de Bacharelado em Biotecnologia da Universidade Federal de Pelotas, sendo organizada para tornar mais democrático o acesso a livros e revistas. Desde sua origem caracterizou-se por um conjunto de atividades solidárias e cooperativas, tendo todo o material do acervo arrecadado através de doações ou trocas. Durante os 18 meses de atividade, a Bbioteca contabilizou cinco mil exemplares recebidos e compartilhados pelo projeto, entre livros e revistas.
PENGARUH LATIHAN GRIP PASSING GAME DAN HEAD RETRUN TERHADAP KEMAMPUAN PASSING CONTROLING PADA PEMAIN 11-12 SSB KUANG SUMBAWA BARAT TAHUN 2022
Authors: Soemardiawan  , Susi Yundarwati  
Published: May 2023

Regarding the focus of this research problem, there is shooting at the football club at the 2022 Space Princess Player Nina, finding that there is still a lack of accuracy, the ability to shoot a lot because when playing the goal always misses to the left and right side, and many balls stray upwards so researchers are very motivated to do research on shooting. Research purpose To Find Out whether or not the Influence of Shoot On Goal With Opening Slalom (Passing Combination) And Shooting Squence (Getting Open) Exercises Increased Football Shooting Results In Space Princess Nina Players in 2022. The research design is to use One group pretest-posttest design. In this study, the population did not use samples, but the entire population was used as a research sample, namely the entire Nina Space Princess Player of 2022, amounting to 20 people. So this study is a population study research. So this study is a population study research. Based on the data obtained, from the results of field trials and discussion of research results it can be concluded that: There is a comparison of numbers that show the results of the initial test and the final test is progressing, in the Shoot On Goal With Opening Slalom (Passing Combination) group the output results using SPSS 17, That the average value of the result before being given a spin shooting exercise is 78.00 and after being treated with the Shoot On Goal With Opening Slalom (Passing Combination) exercise 108.50 means that the average value of football shooting is increased, Based on the output results using SPSS 17 that the average value of the results before being given shooting Squence (Getting Open) practice is 90.00 and after being treated with a target game practice of 120.50 means that the average value of shooting football there is an increase.
DAMPAK SIRKUIT MOTOR CROSS 459 LANTAN TERHADAP PENINGKATAN PENDAPATAN EKONOMI UMKM KAB. LOMBOK TENGAH
Authors: Samiun  , Muhammad Iqbal  , Sugianto  
Published: May 2023

Usaha Mikro, Kecil, dan Menengah (UMKM) merupakan salah satu unit usaha yang memiliki peran penting dalam perkembangan dan pertumbuhan perekonomian Indonesia. Tujuan penelitian ini adalah untuk mengetahui dampak dari pembangunan Cirkuit terhadap perkembangan UMKM di Desa Lantan. Penelitian ini menggunakan teori perkembangan usaha menurut Nurrohmah, (2008). Metode yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Analisis data yang digunakan menurut Miles & Huberman. Hasil Penelitian menunjukkan bahwa sirkuit memberikan dampak yang positif terhadap perkembangan UMKM di Desa lantan, karena UMKM mengalami peningkatan omzet penjualan dan pertumbuhan pelanggan karena disebabkan oleh meningkatnya jumlah wisatawan ke Desa Kuta. Namun untuk UMKM sektor industri pengolahan masih mengalami kesulitan dalam memasarkan produknya dikarenakan belum adanya gerai khusus UMKM. Rekomendasi yang diberikan yaitu dibuatnya gerai khusus UMKM, dan pembangunan fasilitas sarana dan prasarana. Di Indonesia khususnya Lombok tengah , sepeda motor untuk tujuan transportasi telah berkembang dari sekedar sebagai sarana untuk kenyamanan bertransportasi menjadi sebuah gaya hidup di beberapa kalangan tertentu. Salah satunya adalah penggunaan motor trail atau lebih khusus motocross. Motocross merupakan salah satu jenis olahraga otomotif roda dua yang dipacu pada sirkuit off-road, olahraga ekstrim ini pertama kali muncul berasal di negara Ingris, jenis mesin yang digunakan motocross adalah mesin khusus atau biasa disebut SE (special engine). Disebut khusus karena memang mesin ini dibuat sedemikian rupa untuk akselerasi yang maksimal . Menariknya, motorcross saat ini menjadi salah satu ceruk pasar otomotif roda dua yang dilirik para produsen sepeda motor di Indonesia.