bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analysis of low-grade adenosquamous carcinoma of the breast progressing to high-grade metaplastic carcinoma
Authors: Kawachi Kae , Tang Xiaoyan , Kasajima Rika , Yamanaka Takashi , Shimizu Eigo , Katayama Kotoe , Yamaguchi Rui , Yokoyama Kazuaki , Yamaguchi Kiyoshi , Furukawa Yoichi , Miyano Satoru , Imoto Seiya , Yoshioka Emi , Washimi Kota , Okubo Yoichiro , Sato Shinya , Yokose Tomoyuki , Miyagi Yohei 
Published: August 2023

Abstract
Purpose
Low-grade adenosquamous carcinoma (LGASC) is a rare type of metaplastic carcinoma of the breast (MBC) with an indolent clinical course. A few LGASC cases with high-grade transformation have been reported; however, the genetics underlying malignant progression of LGASC remain unclear.

Methods
We performed whole-genome sequencing analysis on five MBCs from four patients, including one case with matching primary LGASC and a lymph node metastatic tumor consisting of high-grade MBC with a predominant metaplastic squamous cell carcinoma component (MSC) that progressed from LGASC and three cases of independent de novo MSC.

Results
Unlike de novo MSC, LGASC and its associated MSC showed no TP53 mutation and tended to contain fewer structural variants than de novo MSC. Both LGASC and its associated MSC harbored the common GNAS c.C2530T:p.Arg844Cys mutation, which was more frequently detected in the cancer cell fraction of MSC. MSC associated with LGASC showed additional pathogenic deletions of multiple tumor-suppressor genes, such as KMT2D and BTG1. Copy number analysis revealed potential 18q loss of heterozygosity in both LGASC and associated MSC. The frequency of SMAD4::DCC fusion due to deletions increased with progression to MSC; however, chimeric proteins were not detected. SMAD4 protein expression was already decreased at the LGASC stage due to unknown mechanisms.

Conclusion
Not only LGASC but also its associated high-grade MBC may be genetically different from de novo high-grade MBC. Progression from LGASC to high-grade MBC may involve the concentration of driver mutations caused by clonal selection and inactivation of tumor-suppressor genes.
Trade, Transport Emissions and Multimarket Collusion with Border Adjustments
Authors: Sikdar Shiva 
Published: August 2023

AbstractWe analyze the impact of border adjustment policies on trade, pollution and welfare when firms, located in different countries, sell differentiated products in geographically-separated markets. Transportation of goods not only incurs a cost, but also generates emissions. We compare outcomes under competition and multimarket collusion. Cooperating governments can implement the first-best using appropriate border adjustments regardless of the market structure. When governments set policies non-cooperatively, the border adjustment tariffs exceed the marginal damage from emissions. While it is expected that colluding firms would reduce trade flows relative to competition, trade increases under collusion, resulting in higher welfare. This highlights the possibility of allowing firms to collude and taxing (part of) their profits, which can be redistributed to citizens or used to mitigate the effects of pollution.
Ineffective implementation of emergency reduction measures against high concentrations of particulate matter in Seoul, Republic of Korea
Authors: Ho Chang-Hoi , Kim Ka-Young 
Published: August 2023

AbstractSince December 30, 2017, the Seoul Metropolitan Government, Republic of Korea, has been implementing emergency reduction measures (ERMs) restricting the operation of industrial sites, thermal power plants, and vehicles when air quality is expected to deteriorate. ERMs are implemented when the present observed concentration of particulate matter (PM) of aerodynamic diameter less than 2.5 μm (PM2.5) and/or the predicted values for the following day exceed a threshold value. In this study, the effectiveness of ERMs was evaluated for 33 days with and 6 days without ERM implementation but where the PM2.5 concentration exceeded the threshold value, until March 15, 2021. Of the 33 days of ERM implementation, on 7 days it was executed despite the thresholds not being met. The ERM on these days might have been properly executed because the pre-notice and implementation of ERM might have reduced the local emissions of air pollutants. Our major findings are that even on days of ERM implementation, there were marginal reductions in vehicle traffic, thermal power generation, and industrial emissions. Second, the concentrations of PM2.5 and related air pollutants in Seoul were almost unchanged for most ERM implementation episodes. Third, most of the 39 (= 33 + 6) days when the air quality worsened were caused by the transboundary transport of air pollutants from China. In conclusion, it was revealed that the currently executed ERM law is insufficient for effectively reducing PM2.5. To achieve the required reductions, it is necessary to undertake stricter policies in Seoul and its neighboring regions.
Diatomaceous Biosilica Doped with Heteroepitaxially Growing Ag/AgCl/CeO2 Composite Nanoparticles: Synthesis, Characterisation and Antibacterial Application
Authors: Wojtczak Izabela , Brzozowska Weronika , Railean Viorica , Bekissanova Zhanar , Trykowski Grzegorz , Sprynskyy Myroslav 
Published: August 2023

AbstractModern technology's development is also towards using microorganisms as micro-factories of biomaterials with unique properties and combining the original properties of biosilica extracted from diatoms (microalgae) together with immobilised silver and cerium in nanoparticle forms allowed to obtain a modern composite material with antibacterial activity. The synthesised composites containing heteroepitaxially growing Ag/AgCl/CeO2 complex nanoparticles were studied using different types of instrumental analysis. SEM-EDX and XRD analysis allowed the qualitative and quantitative determination of the elements present and their forms in the composites. TEM permitted analysis of information about the created nanoparticles shape, size and structure specificity. The possible mechanism of nanoparticle formation was suggested. Antibacterial properties of synthesised composites were characterised using a minimum inhibitory concentration test on six selected bacterial strains. Diatomaceous biosilica containing heteroepitaxially growing silver chloride, metallic silver, and cerium (IV) oxide nanoparticles have been prepared for the first time. The proposed method for synthesising composites did not use toxic reagents, making it environmentally friendly.
Graphical Abstract
Poly(Ethylene-Co-Vinyl Acetate)–Poly(Lactic Acid)–Poly(Styrene-Co-Methyl Methacrylate) Blends: Study of Mechanical Properties Under Hydrolytic Degradation and Cytotoxic Evaluation
Authors: Mendoza-Duarte Mónica Elvira , Roacho-Pérez Jorge Alberto , Reyes Adriana G. Quiroz- , Garza-Treviño Elsa N. , Sánchez-Domínguez Celia N. , García-Casillas Perla Elvia , Vega-Rios Alejandro 
Published: August 2023

Abstract
The present research investigates the hydrolytic degradation of ternary blends composed of poly(ethylene-co-vinylacetate) (EVA), poly(lactic acid) (PLA), and poly(styrene-co-methyl methacrylate)(poly(S-co-MMA) (SMMA) (EPS) blends at a temperature of 37 °C and pH 7.4, monitoring the changes in phosphate buffer solution for 6 months. In addition, the mechanical behavior and morphology of the blends were evaluated from the comparison with the degraded blends against probes non-hydrolytically degraded. Likewise, the hemolytic properties and the cytotoxicity of the blends were estimated to determine their safety if used in medical devices. Ternary blends with higher stiff-elongated properties were composed of 30 wt% EVA—69 wt% PLA and 1 wt% SMMA and prepared by varying the mixing time of each component. EPS samples presented less hydrolytic degradation than PLA. Blending PLA with EVA and SMMA resulted in significant mechanical stability throughout the degradation time. Biocompatibility tests reported that the interaction of EVA/PLA/SMMA films with mesenchymal stem cells showed no evidence of damage in the metabolism of the cells; thus, the films were not dangerous. Furthermore, all tested samples reported values below 5% of hemolysis; hence are classified as non and slightly hemolytic according to ASTM F756. Therefore, polymer EPS blends have potential applications in medical devices.

Graphical abstract
Revisiting the Influence of Confinement on the Pressure Drop in Fixed Beds
Authors: Falkinhoff Florencia , Pierson Jean-Lou , Gamet Lionel , Bourgoin Mickäel , Volk Romain 
Published: August 2023

AbstractWe study the non-turbulent pipe flow of a Newtonian fluid through a confined porous medium made of randomly arranged spherical particles in the situation where the ratio between the pipe diameter over the particle diameter (D/d) is less than 10. Using experiments and numerical simulations, we examine the relation between the flow rate and the mean pressure gradient as a function of the Reynolds number and particle size, and how it is affected by the presence of the walls. We investigate the intrinsic variability of the measurements in relation to the randomness of the particle arrangement and how such variability is linked to spatial fluctuations of pressure within the bed. We observe that as D/d decreases, the pressure gradient presents a stronger variability, particularly in relation to where measurements are taken within the pipe. The study also quantifies the difference between measuring the pressure drop at the wall versus averaging over the entire volume, finding a small difference of $$2.5\%$$

2.5
%

at most. We examine how the mean pressure gradient is affected by the lateral walls, finding that the pressure drop follows a consistent 1/Re scaling regardless of the confinement of the bed. Finally, we observe that the pressure gradient balances the force exerted on the solid spheres with a very weak contribution of the wall friction, showing that the role of confinement corresponds to a global effect on the bed arrangement which in turns affects the mean pressure gradient.
Near-optimal Multiplier-Less Broadband Noise Shaping Filters
Authors: Brachtendorf Hans Georg , Dalpiaz Christoph 
Published: August 2023

AbstractNoise shaping (NS) filters reduce the quantization noise power in one or more frequency band(s) while amplifying it in other bands. Narrow-band noise shaping filters are state of the art in audio signal processing, analog-digital and digital-analog conversion, direct digital synthesis, and other applications. However, it is much more difficult to design broadband NS filters. Since NS filters are used in feedback branches, they must therefore be designed direct path free which imposes a constraint on the filter coefficients. This constraint leads to prohibitive large filter coefficients employing state of the art filter design techniques.This paper investigates the theoretical bound for NS filters and shows results about a novel design method for broadband FIR and IIR noise shaping filters and its multiplier-less hardware implementation. The method employed is a purely numerical approximation technique and leads to filter designs close to the discussed theoretical bound. The quantization of the filter coefficients is performed by a Canonical Signed Digit (CSD) representation of the coefficients. Two alternative architectures for the implementation of the filters are discussed. The design technique and the CSD quantization are realized in a toolbox. The filters were moreover implemented in VHDL.
Difficulties on the access to innovative targeted therapies for lung cancer in Spain
Authors: Calvo Virginia , Camps Carlos , Carcereny Enric , Cobo Manuel , Dómine Manuel , García Campelo María Rosario , González Larriba José Luis , Guirado María , Hernando-Trancho Florentino , Massutí Bartomeu , Nadal Ernest , Rodríguez-Abreu Delvys , Sánchez Alfredo , Sullivan Ivana Gabriela , Provencio Mariano ,   the Spanish Lung Cancer Group (SLCG/GECP)
Published: August 2023

Abstract
Purpose
Spanish Lung Cancer Group (SLCG) conducted a review to analyze the barriers to access to innovative targeted therapies for non-small cell lung cancer (NSCLC) in clinical practice in Spain.

Methods
Review all relevant content published on websites of European Commission, European Medicines Agency, and Spanish Agency of Medicines and Medical Products regarding the authorization and access to oncology treatments.

Results
More than 20 targeted therapies are available to treat different molecular alterations in patients with NSCLC. European Commission has approved treatments for genomic alterations involving the following genes: ALK, RET, ROS1, EGFR, BRAF, NTRK, KRAS, MET. However, the availability of these therapies in Spain is not complete, as innovative treatments are not reimbursed or funded late, with only five of these alterations currently covered by National Health System.

Conclusion
SLCG considers imperative to improve the access in Spain to innovative treatments for NSCLC to reduce inequity across European countries.
Real-world study on microsatellite instability and mismatch repair deficiency testing patterns among patients with metastatic colorectal cancer in Spain
Authors: Garcia-Carbonero Rocio , González Astorga Beatriz , Vidal Tocino Rosario , Contreras Toledo Débora , Pericay Carles , Fernández Montes Ana , Falcó Esther , González Cordero Marta , Reina Zoilo Juan José , Alonso Vicente , Rodríguez Salas Nuria , Gil-Raga Mireia , Santos Cristina , Páez David , Anton-Pascual Beatriz , Aguilar Fernando , Morales Pilar 
Published: August 2023

Abstract
Purpose
Clinical practice guidelines recommend that all patients with metastatic colorectal cancer (mCRC) should be tested for mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). We aimed to describe the dMMR/MSI-H testing practice in patients with mCRC in Spanish centers.

Methods
Multicenter, observational retrospective study that included patients newly diagnosed with mCRC or who progressed to a metastatic stage from early/localized stages.

Results
Three hundred patients were included in the study from May 2020 through May 2021, with a median age of 68 years, and two hundred twenty-five (75%) had stage IV disease at initial diagnosis; two hundred eighty-four patients received first-line treatment, and dMMR/MSI-H testing was performed in two hundred fifty-one (84%) patients. The results of the dMMR/MSI-H tests were available in 61 (24%) of 251 patients before the diagnosis of metastatic disease and in 191 (81%) of 236 evaluable patients for this outcome before the initiation of first-line treatment. Among the 244 patients who were tested for dMMR/MSI-H with IHC or PCR, 14 (6%) were MMR deficient. The most frequent type of first-line treatment was the combination of chemotherapy and biological agent, that was received by 71% and 50% of patients with MMR proficient and deficient tumors, respectively, followed by chemotherapy alone, received in over 20% of patients in each subgroup. Only 29% of dMMR/MSI-H tumors received first-line immunotherapy.

Conclusion
Our study suggests that a high proportion of patients with mCRC are currently tested for dMMR/MSI-H in tertiary hospitals across Spain. However, there is still room for improvement until universal testing is achieved.
Trial registration: Not applicable.
Reconsidering False Positives in Machine Learning Binary Classification Models of Suicidal Behavior
Authors: Haghish E. F. , Czajkowski Nikolai 
Published: August 2023

AbstractWe posit the hypothesis that False Positive cases (FP) in machine learning classification models of suicidal behavior are at risk of suicidal behavior and should not be seen as sheer classification error. We trained an XGBoost classification model using survey data from 173,663 Norwegian adolescents and compared the classification groups for several suicide-related mental health indicators, such as depression, anxiety, psychological distress, and non-suicidal self-harm. The results showed that as the classification is made at higher risk thresholds - corresponding to higher specificity levels - the severity of anxiety and depression symptoms of the FP and True Positive cases (TP) become significantly more similar. In addition, psychological distress and non-suicidal self-harm were found to be highly prevalent among the FP group, indicating that they are indeed at risk. These findings demonstrate that FP are a relevant risk group for potential suicide prevention programs and should not be dismissed. Although our findings support the hypothesis, we account for limitations that should be examined in future longitudinal studies. Furthermore, we elaborate on the rationale of the hypothesis, potential implications, and its applicability to other mental health outcomes.
Current challenges in the prevention and management of post-thrombotic syndrome—towards improved prevention
Authors: Wang Julie , Smeath Elise , Lim Hui Yin , Nandurkar Harshal , Kok Hong Kuan , Ho Prahlad 
Published: August 2023

AbstractPost-thrombotic syndrome (PTS) is a common and potentially debilitating complication of deep vein thrombosis (DVT), affecting up to 50% of DVT patients. The consequence of this chronic condition includes reduced quality of life, increased use of the healthcare system and decreased productivity. The societal impact of this condition is projected to increase, given our ageing population and increased burden of thrombotic diseases. Despite significant recent advances in our understanding of PTS, many unanswered questions remain. Currently, there are few effective and proven options for established PTS; hence, the emphasis should be on instituting effective prevention to reduce the progression to PTS. Effective anticoagulation lowers the risk of PTS, with direct oral anticoagulants appearing to outperform vitamin-K antagonists. However, the evidence for elastic compression stockings and endovascular thrombolysis or thrombectomy techniques remains unclear. Accurate identification of individuals at high risk of developing PTS may also improve the targeting of preventative interventions. This review will examine the current body of evidence regarding PTS, with a focus on preventative strategies as well as novel biomarkers.
Brief update on systemic therapies in myeloproliferative neoplasms
Authors: Steichen Janine , Wolf Dominik 
Published: August 2023

SummaryOver the past years we have gained considerable insights into the biology and consequent therapeutic options in myeloproliferative neoplasms. In this review we aim to highlight the most relevant recent developments in this field with special focus on primary as well as secondary myelofibrosis and polycythemia vera.
New taxa of Pelecinidae (Hymenoptera) from the mid-Cretaceous Burmese amber of Northern Myanmar
Authors: Uchida Kei 
Published: August 2023

AbstractThree specimens of Pelecinidae preserved in mid-Cretaceous Burmese amber from Northern Myanmar were examined and described. Ampluspelecinus robustus gen. et sp. nov. and Eopelecinus diminutivum sp. nov. of Pelecinidae from mid-Cretaceous Burmese amber are characterized by the shape and size of their mesosoma, metasoma, and wing venation. Ampluspelecinus robustus is distinguished from other pelecinid species by its length ratio of metasomal segments, 2r-rs in the forewing forming an “X” pattern, with Rs2 extending approximately two-thirds toward the forewing apex. E. diminutivum sp. nov. is distinguished by its metasomal length ratio and swollen fore, mid, and hind femora. In addition, both female and male specimens are described from amber, which is unusual because male pelecinid wasps, both extant and extinct, are relatively rare. The male specimen is the smallest Pelenicidae wasp reported to date.
The Asymmetric five-card trick: working with variable encoding in card-based protocols
Authors: Guillen Luis 
Published: August 2023

AbstractRecently, card-based protocols have been extensively explored to illustrate relatively complex cryptographic concepts, such as Secure Multiparty Computations, so that even non-specialists can understand them. These protocols rely on three elements: a given alphabet with a set number of physical cards, encoding those cards, and shuffling operations. However, the execution is becoming over-complicated, as most follow the same encoding: fixed uniform disclosed encoding, which constrains other elements and decreases their expressiveness. This paper introduces the asymmetric five-card trick, a generalization of the five-card trick (a seminal work in the field of card-based cryptography) with the added feature of allowing variable encoding. To do so, we propose a pre-process called “handshake” that allows protocols to adapt operations based on players’ encoding. The protocol handshake is included as part of the protocol’s production phase in the proposed general framework, which is negotiated before its execution. Finally, this paper also introduces the notion of time and space complexity in card-based protocols to assess their production and execution’s lower bounds.
Is a non-representative convenience sample of adults good enough? Insights from an economic experiment
Authors: Ellis Sean F. , Savchenko Olesya M. , Messer Kent D. 
Published: August 2023

AbstractRecruitment of representative and generalizable adult samples is a major challenge for researchers conducting economic field experiments. Limited access to representative samples or the high cost of obtaining them often leads to the recruitment of non-representative convenience samples. This research compares the findings from two field experiments involving 860 adults: one from a non-representative in-person convenience sample and one from a representative online counterpart. We find no meaningful differences in the key behaviors of interest between the two samples. These findings contribute to a growing body of literature demonstrating that non-representative convenience samples can be sufficient in certain contexts.
Between You and I: A Methodological, Mixed-method Corpus-pragmatic Approach to Hypercorrect Uses of Subject Pronouns in Object Position
Authors: Kirner-Ludwig Monika , Oberhofer Kathrin , Heiss Julia 
Published: August 2023

AbstractThe present paper takes a corpus-pragmatic approach to an issue traditionally situated at the interface of sociolinguistics, grammatical prescriptivism and syntax: the use of the hypercorrect structures <X and I> and <I and X> in object position and British and American English speakers’ usage of such pronoun binomials as prestige constructions. Here, we dedicate significant space to the meta-methodological level pertaining to the corpus-linguistic challenges entailed in systematically identifying relevant occurrences of coordinated noun phrases that feature at least one nominal component unambiguously case-marked. We use a self-compiled corpus of 14,165,810 words of transcribed telecinematic discourse in order to not only establish the extent of any hypercorrect usage, but also to see it in relation with unmarked and both grammatically correct and incorrect uses of the subject and object forms.