bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ryugu Sample Database System (RS-DBS) on the Data Archives and Transmission System (DARTS) by the JAXA curation
Authors: Nishimura Masahiro , Nakato Aiko , Abe Masanao , Nagashima Kana , Soejima Hiromichi , Yada Toru , Yogata Kasumi , Miyazaki Akiko , Hatakeda Kentaro , Yoshitake Miwa , Iwamae Ayako , Pilorget Cedric , Brunetto Rosario , Loizeau Damien , Bibring Jean-Pierre , Riu Lucie , Yumoto Koki , Cho Yuichiro , Yabe Yuna , Sugita Seiji , Ito Motoo , Okada Tatsuaki , Tachibana Shogo , Usui Tomohiro 
Published: September 2023

AbstractThe JAXA Astromaterials Science Research Group developed a web-based database system for the Hayabusa2-returned samples from C-type asteroid Ryugu. The Ryugu Sample Database System database (RS-DBS) is designed as an online catalog for users of wide scientific communities to choose their preferred samples and propose the sample loan through the JAXA Ryugu Sample Announcement of Opportunity. Ryugu samples can be sorted and given identification numbers as individual particles larger than 1 mm and aggregate samples consisting of less than 1 mm particle through the Phase1 curation (i.e., the initial description). The RS-DBS lists all samples with analytical data such as a microscopy image, size, mass, spectroscopic data, and shape model obtained by the initial description at the JAXA curation facility. The list also includes research results conducted by previous projects (i.e., the Hayabusa2 initial analysis team and Phase2 curation teams). The RS-DBS, built with open-source technologies, archives the data securely and long-term on the Data Archives and Transmission System (DARTS) at ISAS/JAXA.
Graphical Abstract
Metal ion removal using a low-cost coconut shell activated carbon bioadsorbent in the recovery of lactic acid from the fermentation broth
Authors: Wongvitvichot Wasupon , Thitiprasert Sitanan , Thongchul Nuttha , Chaisuwan Thanyalak 
Published: September 2023

AbstractDownstream recovery and purification of lactic acid from the fermentation broth using locally available, low-cost materials derived from agricultural residues was demonstrated herein. Surface modification of coconut shell activated carbon (CSAC) was performed by grafting with carboxymethyl cellulose (CMC) using citric acid (CA) as the crosslinking agent. A proper ratio of CMC and CA to CSAC and grafting time improved the surface functionalization of grafted nanostructured CMC-CSAC while the specific surface area and porosity remained unchanged. Lactic acid was partially purified (78%) with the recovery percentage of lactic acid at 96% in single-stage adsorption at room temperature and pH 6 with a 10:1 ratio of cell-free broth to CMC-CSAC bioadsorbent. A thermodynamic study revealed that the adsorption was exothermic and non-spontaneous while the Langmuir isotherm model explained the adsorption phenomena. The results in this study represented the potential of waste utilization as solid adsorbents in green and low-cost adsorption technology.
Graphical Abstract
Statement on chronotherapy for the treatment of hypertension: consensus document from the Korean society of hypertension
Authors: Park Sungha , Ihm Sang-Hyun , Cho In-Jeong , Kim Dae-Hee , Park Jae Hyeong , Chung Woo-Baek , Choi Seonghoon , Lee Hae Young , Kim Hyeon Chang , Sohn Il Suk , Lee Eun Mi , Kim Ju Han , Kim Kwang-il , Cho Eun Joo , Sung Ki-Chul , Shin Jinho , Pyun Wook Bum 
Published: September 2023

AbstractNocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving non dipping and rising patterns to dipping patterns, and improving cardiovascular prognosis. However, criticism and concerns have been raised regarding the design of these studies, such as the Hygia study, and the implausible clinical benefits in cardiovascular outcomes considering the degree of BP lowering from bedtime dosing. Studies have shown that there is no consistent evidence to suggest that routine administration of antihypertensive medications at bedtime can improve nocturnal BP and early morning BP control. However, in some cases of uncontrolled nocturnal hypertension and morning hypertension, such as in those with diabetes mellitus, chronic kidney disease, and obstructive sleep apnea, bedtime dosing has shown efficacy in reducing evening and early morning BP. The recently published the Treatment in Morning versus Evening (TIME) study failed to demonstrate benefit of bedtime dosing in reducing cardiovascular outcomes in patients with hypertension. With issues of the Hygia study and negative results from the TIME study, it is unclear at this time whether routine bedtime dosing is beneficial for reducing cardiovascular outcomes.
The development of the People with Aphasia and Other Layperson Involvement (PAOLI) framework for guiding patient and public involvement (PPI) in aphasia research
Authors: Charalambous Marina , Kountouri Alexia , Schwyter Jürg Rainer , Annoni Jean-Marie , Kambanaros Maria 
Published: September 2023

Abstract
Background
Patient and Public Involvement (PPI) in aphasia research requires researchers to include people with aphasia as research partners from the beginning of the study. Yet the quality of reporting on the level and type of involvement is poorly documented in the absence of a framework to guide PPI in aphasia research. This study aimed to extract the items and statements relevant for the development of the People with Aphasia and Other Layperson Involvement (PAOLI) framework for designing and implementing PPI in aphasia research, in collaboration with people with aphasia.

Method
The method recommended by the EQUATOR network was followed. This involved: (1) evidence from a scoping review, (2) a thematic analysis of the in-depth interviews, of people with stroke and aphasia, on the topics to be included in the pilot draft, (3) a two round Delphi survey for item/statement selection and (4) an experts’ consensus meeting. The research team involved two PPI partners with chronic stroke-induced aphasia. The research process involved co-design and was informed by the Dialogue model.

Results
Twenty-three panellists, from 13 countries, voted in round one with 87% (20/23) responding in round two. The final PAOLI framework includes the following 17 items (with 66 descriptive statements): establish collaborations, recruit patients, gain informed consent, organize induction meetings, train patient partners, create communication links, engage communication partners, conceptualize topics, establish research priorities, reach consensus, work with co-design methods, develop proposals, assist with dissemination of results, promote implementation of the outcomes, support patient partners and promote self-evaluation, monitor progress and assess impact of the patient involvement. These items were considered by the panellists as the most relevant for the involvement of people with aphasia as research partners.

Conclusion
The PAOLI is the first international consensus framework for guiding patient involvement in aphasia research. Researchers are encouraged to adopt the framework to improve the quality of their research by promoting the meaningful involvement of people with aphasia within the research team from the start.
Short-pulse laser plus subthreshold diffuse laser for serous retinal detachment in dome-shaped macula
Authors: Rodrigues Murilo Wendeborn , Bastos Thais , Gonçalves Annelise Nicotti , Cardillo José Augusto , Messias André , de Souza Eduardo Cunha , Jorge Rodrigo 
Published: September 2023

Abstract
Background
First described by Gaucher and associates in 2008, dome-shaped macula (DSM) is an anterior convex protrusion of the macula visible on OCT (optical coherence tomography). Visual impairment in DSM results mainly from sub-foveal serous retinal detachment (SRD). Herein, this original study from retrospective data analysis evaluate the anatomical and functional effects of Pascal® short-pulse (SP) laser plus endpoint management (EpM) subthreshold diffuse laser (SDL) in patients with SRD due to DSM.

Methods
This retrospective study included seven consecutive patients (eight eyes) with SRD secondary to dome-shaped macula who underwent a comprehensive ophthalmological evaluation including logMAR BCVA, slit-lamp biomicroscopy, indirect ophthalmoscopy, and spectral-domain optical coherence tomography (SD-OCT) (Spectralis; Heidelberg Engineering, Germany) before combined Pascal® SP laser plus EpM-SDL with 1 to 6 month intervals, postoperatively, with a mean ± standard error (SE) follow-up time of 12.92 ± 1.34 months.

Results
Eight eyes from seven patients were analyzed in this study. At baseline, mean BCVA (LogMAR) ± standard error (SE) and mean CST (central subfield thickness)(µm) ± SE were 0.6125 ± 0.14 and 412.50 ± 24.65, respectively. After a mean follow-up time of 12.92 ± 1.34 months, mean CST (µm) ± SE and BCVA (LogMAR) ± SE were 294.75 ± 19.68 (p = 0.0078) and 0.4537 ± 0.12 (p = 0.0313), respectively. A statistically significant reduction in mean CST and an improvement in mean BCVA were noted after SRD resolution with laser therapy application. The mean serous retinal detachment resolution time (months) ± SE was 3.75 ± 1.08. No adverse events were registered, including enlargement of atrophic alterations and choroidal neovascularization.

Conclusions
The novel combined laser modality with Pascal® SP laser plus EpM-SDL treatment may induce subretinal fluid regression and BCVA improvement 1 year after treatment in DSM patients with SRD.
M6A transcriptome-wide map of circRNAs identified in the testis of normal and AZ-treated Xenopus laevis
Authors: Zhang Xin , Sai Linlin , Zhang Weiliang , Kan Xingzheng , Jia Qiang , Bo Cunxiang , Yin Wenhui , Shao Hua , Han Mingming , Peng Cheng 
Published: September 2023

Abstract
Background
Evidence showed that N6-methyladenosine (m6A) is strongly associated with male germline development. However, the role of m6A methylation on circRNAs in amphibians remains unknown. In this study, we conducted m6A sequencing analysis to explore the m6A transcriptome-wide profile of circRNAs in testis tissues of Xenopus laevis (X. laevis) with and without treatment with 100 µg/L atrazine (AZ).

Results
The analysis showed that m6A modification of circRNAs enriched in sense overlapping in testes of X. laevis. We identified the differential m6A modification sites within circRNAs in testes of AZ-exposed X. laevis and compared that with animals from control group. The results showed that a total of 1507 methylated m6A sites was induced by AZ (760 up-methylated and 747 down-methylated). The cross-analysis exhibited a negative correlation of differentially methylated m6A peaks and circRNAs expression level. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that 20 key pathways may be involved in the mechanism of testis damage of AZ-exposed X. laevis.

Conclusions
These findings indicated that differentially m6A-methylated circRNAs may play important roles in abnormal testis development of AZ-exposed X. laevis. This study is the first report about a map of m6A modification of circRNAs in male X. laevis and provides a basis for further studying on the function and mechanism of m6A methylation of circRNAs in the testis development of amphibian.
Challenges and recommendations for measuring time devoted to implementation and intervention activities in health equity-focused, resource-constrained settings: a qualitative analysis
Authors: Levy Douglas E. , Singh Deepinder , Aschbrenner Kelly A. , Davies Madeline E. , Pelton-Cairns Leslie , Kruse Gina R. 
Published: September 2023

Abstract
Background
There is little guidance for conducting health equity-focused economic evaluations of evidence-based practices in resource-constrained settings, particularly with respect to staff time use. Investigators must balance the need for low-touch, non-disruptive cost data collection with the need for data on providing services to priority subpopulations.

Methods
This investigation took place within a pilot study examining the implementation of a bundled screening intervention combining screening for social determinants of health and colorectal cancer at four federally qualified health centers (FQHCs) in the Boston metropolitan area. Methods for collecting data on personnel costs for implementation and intervention activities, including passive (automatic) and active (non-automatic, requiring staff time and effort) data collection, as well as three alternate wordings for self-reporting time-use, were evaluated qualitatively using data collected through interviews with FQHC staff (including clinicians, population health staff, and community health workers) and assessments of data completeness.

Results
Passive data collection methods were simple to execute and resulted in no missing data, but missed implementation and intervention activities that took place outside planned meetings. Active cost data collection using spreadsheets was simple for users when applied to care processes already tracked in this fashion and yielded accurate time use data. However, for tasks where this was not typical, and when tasks were broken up over multiple sessions, spreadsheets were more challenging to use. Questions asking about time use for a typical rather than specific time period, and for typical patients, yielded the most reliable and actionable data. Still, even the best-performing question had substantial variability in time use estimates. Participants noted that patient characteristics of interest for equity-focused research, including language spoken, adverse social determinants of health, and issues related to poverty or mental health, all contributed significantly to this variability.

Conclusions
Passively collected time use data are the least burdensome and should be pursued in research efforts when possible, but should be accompanied by qualitative assessments to ensure the data are an accurate reflection of effort. When workflows are already tracked by active data collection, these are also strong data collection methods. Self-reported time use will be most accurate when questions inquire about “typical” tasks and specific types of patients.
Neural-network–based algorithm for the inverse problem of measuring K-shell ionization cross-sections of Si induced by 3–25 keV electrons and 4.5–9 keV positrons using the thick-target method
Authors: Li Y. D. , Wu Y. , Huang C. J. , Liu Z. H. , Pan M. 
Published: September 2023

Abstract
In this study, a neural network method is proposed for solving the inverse problem in the measurement of inner-shell ionization cross-sections using the thick-target method. It was applied to calculate the K-shell ionization cross-section of silicon (Si) from positron impacts in the energy range from 4.5 to 9 keV, using a Monte Carlo simulation program called PENELOPE to construct a comprehensive characteristic X-ray yield and cross-section database, serving as a foundation for training the neural network. The experimental values are compared with those obtained using regularization, yield differential, and distorted-wave Born approximation (DWBA) theoretical models. Our findings reveal that the cross-section results obtained from all three algorithms are in good agreement with the theoretical DWBA values within the error range. Moreover, our study highlights the superiority of the neural network algorithm in solving ill-posed problems, compared with traditional regularization algorithms and the yield differential method. Furthermore, we re-analyse the experimental data of electron-induced ionization cross-sections on a pure thick Si target in the energy range from 3 to 25 keV, which were originally obtained by Zhu et al. who used a regularization method. The reprocessed cross-sections obtained in this study exhibit good agreement with the reported results within the error range. To the best of our knowledge, this is the first experimental report of the K-shell ionization cross-sections of Si from positron impact.
The Effect of Testosterone Replacement Therapy on Nonalcoholic Fatty Liver Disease in Older Hypogonadal Men
Authors: Lee Hae Seung , Han Sang Hun , Swerdloff Ronald , Pak Youngju , Budoff Matthew , Wang Christina 
Published: September 2023

Abstract

Context
Male hypogonadism is associated with visceral obesity and the metabolic syndrome: factors important for the development of nonalcoholic fatty liver disease (NAFLD). The Testosterone Trials (The T Trials) showed testosterone (T) treatment compared with placebo in older hypogonadal men was associated with decreases in cholesterol and insulin levels suggesting that T treatment may improve NAFLD.

Objective
Compare effects of T vs placebo treatment on NAFLD scores and liver scans in elderly hypogonadal men.

Methods
Secondary data analyses from 479 older hypogonadal men with total T &lt; 275 ng/dL from The T Trials were performed. Three clinical liver fat scores—lipid accumulation product index, hepatic steatosis index, nonalcoholic fatty liver disease-metabolic syndrome score—and liver computed tomography (CT) Hounsfield units and liver to spleen ratio were evaluated at baseline and 12 months after treatment.

Results
There were no statistically significant differences of change in lipid accumulation product index (P = .98), hepatic steatosis index (P = .67), and nonalcoholic fatty liver disease-metabolic syndrome (P = .52) in 246 men treated with T compared with 233 treated with placebo for 12 months. Liver CT showed no statistically significant difference of change in Hounsfield units (P = .24; n = 71 for T, n = 69 for placebo) and liver to spleen ratio (P = .74; n = 55 for T, n = 62 for placebo) between the 2 groups.

Conclusions
Our study did not show improvement of NAFLD in older hypogonadal men after 12 months of T vs placebo treatment, as assessed by 3 clinical scores and liver CT for hepatic steatosis. Future studies with longer treatment duration and additional NAFLD diagnostic modalities as primary outcome are warranted.
Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study
Authors: Ayala Ivan Nicolas , Soto Jacome Cristian , Toro-Tobon David , Golembiewski Elizabeth , Garcia-Bautista Andrea , Hidalgo Jessica , Cordova-Madera Sandra , Al Anbari Raghda , Sohn R Jessica , Singh Ospina Naykky , Maraka Spyridoula , Joseph Marina , Brito Juan P 
Published: September 2023

Abstract

Context
Levothyroxine is one of the most prescribed medications in the United States.

Objective
This study explores the appropriateness of levothyroxine prescriptions.

Methods
A retrospective multicenter study was conducted on adult patients who were prescribed levothyroxine for the first time between 2017 and 2020 at three academic centers in the United States. We classified each case of levothyroxine initiation into one of three mutually exclusive categories: appropriate (clinically supported), indeterminate (clinically unclear), or nonevidence based (NEB, not clinically supported).

Results
A total of 977 participants were included. The mean age was 55 years (SD 19), there was female (69%) and White race predominance (84%), and 44% had possible hypothyroid symptoms. Nearly half of the levothyroxine prescriptions were considered NEB (528, 54%), followed by appropriate (307, 31%) and indeterminate (118, 12%). The most common reason for NEB prescription was an index thyrotropin (TSH) value of less than 10 mIU/L without previous TSH or thyroxine values (131/528, 25%), for appropriate prescription, was overt hypothyroidism (163/307, 53%), and for an indeterminate prescription was a nonconfirmed subclinical hypothyroidism with TSH greater than or equal to 10 mIU/L (no confirmatory testing) (51/118, 43%). In multivariable analysis, being female (odds ratio [OR]: 1.3; 95% CI, 1.0-1.7) and prescription by a primary care provider (OR: 1.5; 95% CI, 1.2-2.0) were associated with NEB prescriptions.

Conclusion
There is a considerable proportion of NEB levothyroxine prescriptions. These results call for additional research to replicate these findings and to explore the perspective of those prescribing and receiving levothyroxine.
Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity
Authors: Sharma Aditi , Papanikolaou Nikoleta , Abou Sherif Sara , Dimakopolou Anastasia , Thaventhiran Thilipan , Go Cara , Holtermann Entwistle Olivia , Brown Adrian , Luo Rong , Jha Rama , Prakash Anavi , Khalifa Dalia , Lewis Hannah , Ramaraju Sruthi , Leeds Anthony R , Chahal Harvinder , Purkayastha Sanjay , Henkel Ralf , Minhas Sukhbinder , Frost Gary , Dhillo Waljit S , Jayasena Channa N 
Published: September 2023

Abstract

Introduction
Obesity increases risks of male infertility, but bariatric surgery does not improve semen quality. Recent uncontrolled studies suggest that a low-energy diet (LED) improves semen quality. Further evaluation within a randomized, controlled setting is warranted.

Methods
Men with obesity (18-60 years) with normal sperm concentration (normal count) (n = 24) or oligozoospermia (n = 43) were randomized 1:1 to either 800 kcal/day LED for 16 weeks or control, brief dietary intervention (BDI) with 16 weeks’ observation. Semen parameters were compared at baseline and 16 weeks.

Results
Mean age of men with normal count was 39.4 ± 6.4 in BDI and 40.2 ± 9.6 years in the LED group. Mean age of men with oligozoospermia was 39.5 ± 7.5 in BDI and 37.7 ± 6.6 years in the LED group. LED caused more weight loss than BDI in men with normal count (14.4 vs 6.3 kg; P &lt; .001) and men with oligozoospermia (17.6 vs 1.8 kg; P &lt; .001). Compared with baseline, in men with normal count total motility (TM) increased 48 ± 17% to 60 ± 10% (P &lt; .05) after LED, and 52 ± 8% to 61 ± 6% (P &lt; .0001) after BDI; progressive motility (PM) increased 41 ± 16% to 53 ± 10% (P &lt; .05) after LED, and 45 ± 8% to 54 ± 65% (P &lt; .001) after BDI. In men with oligozoospermia compared with baseline, TM increased 35% [26] to 52% [16] (P &lt; .05) after LED, and 43% [28] to 50% [23] (P = .0587) after BDI; PM increased 29% [23] to 46% [18] (P &lt; .05) after LED, and 33% [25] to 44% [25] (P &lt; .05) after BDI. No differences in postintervention TM or PM were observed between LED and BDI groups in men with normal count or oligozoospermia.

Conclusion
LED or BDI may be sufficient to improve sperm motility in men with obesity. The effects of paternal dietary intervention on fertility outcomes requires investigation.