bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct to Implant versus 2-Stage Expander Implant Immediate Breast Reconstruction: Comparison of Incidence and Predictors of Complications
Authors: ALTİNKAYA Altug , YAZAR Sukru , KARA Halil , ARIKAN Akif Enes , URAS Cihan 
Published: September 2023

Purpose: The most important discussion about the direct-to-implant (DTI) reconstruction is the risk of ischemic problems. Therefore, there is an ongoing debate about the effectiveness and reliability of DTI reconstruction. The current study aimed to compare the outcomes of patients undergoing DTI and expander implant (EI) reconstruction and to determine the factors that may affect the occurrence of complications.
Methods: Sixty patients who underwent immediate implant reconstruction over a two-year period were included in the study. Demographic characteristics, operative characteristics and postoperative complications of the patients were retrieved retrospectively from patient records.
Results: Reconstruction was performed on 34 and 27 breasts in the DTI and EI groups, respectively. The mean follow-up period of the patients was 13.8 months (range 6–28 months). Although the postoperative complication rates were high in the DTI group, no statistically significant difference was found between the two groups (p = 0.585). No statistically significant difference was found between the two groups in terms of implant failure (p = 0.579). Implant volumes of patients with complications in the DTI group were significantly higher than those without complications (p = 0.049).
Conclusion: While DTI was similar to EI reconstruction in terms of implant failure, overall complication rates were higher than those in EI reconstruction. The volume of the implant is a factor that affects the development of complications in DTI reconstruction. DTI reconstruction is a reliable method that can achieve similar results to EI reconstruction with fewer surgical procedures in suitably selected patients.
Changes in Symptom Severity and Sleeping Habits After Earthquake in Children and Adolescents with Autism Spectrum Disorder: The Case of the Kahramanmaras Earthquake in 2023, Turkey
Authors: EROĞLU Mehtap , YAKŞİ Neşe 
Published: September 2023

Purpose: Autism Spectrum Disorders (ASD) are a group of diseases that appear with difficulties in social interaction and communication skills, limited repetitive interests and behaviours. Natural disasters, especially earthquakes, can cause psychological disorders. A review of the disaster literature shows that natural disasters do not affect individuals in the same way; children and people with disabilities such as ASD are considered the most vulnerable group. It was aimed to evaluate the post-earthquake effects on the children and adolescents diagnosed with ASD in the Kahramanmaras-centered earthquake on February 6, 2023.
Methods: 22 children and adolescents diagnosed with ASD were included in the study. Children with ASD who applied to the Hatay Field Hospital Child and Adolescent Psychiatry outpatient clinic three months after the earthquake were evaluated. Sociodemographic Data Form, Aberrant Behavior Checklist (AbBC), the Child Sleep Habits Questionnaire (CSHQ), Autism Behavior Checklist (ABC) scales were administered.
Results: This study included 19 (86.4%) boys and 3 (13.6%) girls. The age of the participants was 9.92±3.52 years. AbBC-hyperactive (p
PENGARUH JENIS PELARUT PADA METODE MASERASI TERHADAP KARAKTERISTIK EKSTRAK DAUN KAYU PUTIH (Eucalyptus pellita)
Authors: Pamungkas Dedek Aji , Nofita Nofita , Ulfa Ade Maria , Kurniati Mala 
Published: September 2023

Obat tradisional di Indonesia semakin mendapat banyak perhatian seiring semakin mahalnya harga obat. Salah satu tanaman yang dipercaya sebagai obat tradisional adalah kayu putih (Eucalyptus pellita), dikarenakan daun kayu putih mengandung metabolit sekunder. Tujuan penilitian ini yaitu untuk mengetahui apakah ekstrak dari daun kayu putih (Eucalyptus pellita) dengan pelarut polar, semi polar dan non polar mengandung senyawa metabolit sekunder. Hasil penilitian menunjukkan bahwa daun Eucalyptus positif mengandung flavonoid, tanin dan total fenolik. Adanya reaksi yang terjadi pada tabung reaksi adanya endapan berwarna merah bata dapat dikatakan ekstrak daun Eucalyptus pellita positif adanya kandungan tanin. Hasil rendemen dari metode ekstraksi digesti dan maserasi yang telah dilakukan diperoleh E1:20% E2:18,6% E3:16%. Liquid Chromatography-Mass Spectrometry (LCMS) adalah metode kimia analitik yang menggabungkan pemisahan kromatografi cair dengan analisis spektroskopi massa. Metode ini dapat mengidentifikasi perbedaan dari ekstrak. Hasil dari pengukuran absorbansi pembanding asam galat diperoleh kurva linear seperti pada gambar R2 yaitu 0,9609 menunjukkan linearitas yang baik, maka persamaan regresi linear (y=0,0116x+0036) didapatkan kadar total fenol pada daun Eucalyptus pellita yaitu 0,083 mg GAE/g maka dapat dikatakan bahwa Eucalyptus pellita positif mengandung total fenolik. Kata kunci: Daun Kayu Putih (Eucalyptus pellita), Flavonoid, Tanin, Total Fenolik, LC/MS.
Особливості росту штучних дубових молодняків, створених сіянцями із закритою кореневою системою, в ДП «Харківська ЛНДС»
Authors: Даниленко О. М. , Румянцев М. Г. , Тарнопільський П. Б. , Ющик В. С. , Мостепанюк А. А. 
Published: September 2023

Наведено таксаційні показники штучних дубових молодняків, створених сіянцями із закритою кореневою системою, в лісовому фонді державного підприємства «Харківська лісова науково-дослідна станція». Виявлено, що дуб звичайний (Quercus robur L.) у складі молодняків, створених сіянцями, під час вирощування яких застосовували методи інтенсифікації (кореневе підживлення добривами і внесення до ґрунтової суміші мікробних препаратів та суперабсорбентів), росте краще, порівнюючи з контролем (молодняками, створеними сіянцями без застосування підживлення добривами і внесення до ґрунтової суміші мікробних препаратів та суперабсорбентів). Сіянці дуба вирощували в умовах закритого і відкритого ґрунту в контейнерах з агроволокна на субстраті, що складався із суміші темно-сірого середньосуглинкового ґрунту й торфу у співвідношенні за об’ємом 3 : 1. Виявлено, що застосовані методи інтенсифікації росту сіянців позитивно вплинули на приживлюваність висаджених рослин на лісокультурній площі і подальший успішний ріст у культурах. Водночас із віком різниці між варіантами досліду зменшувалися.
Patterns of Patient Recruitment in Clinical Studies on the Example of International Multicenter Clinical Studies (IMCTs)
Authors: Milovanov S. S. 
Published: September 2023

Introduction. Patient recruitment is one of the main quantitative and qualitative characteristics of a clinical trial. As a quantitative characteristic, the recruitment of patients is, first of all, the final figure necessary to answer the researcher's question; as a qualitative characteristic, the recruitment of patients is a process subject to influence. The recruitment of patients in the center is determined by the rate per month and allows you to gain the statistical power of the protocol, and if the recruitment of patients does not reach the planned capacity, then the capacity may not be gained and this leads to the failure of the clinical trial. Failures in patient recruitment reported in the literature lead to more than 80 % of failed clinical trials of all phases. Patient recruitment as a process is influenced by various factors, and the authors identify recruitment predictors, recruitment facilitators, and barriers to patient recruitment.Aim. To consider the general features and patterns of recruitment of patients in clinical trials on the example of international multicenter clinical trials.Materials and methods. We analyzed the quantitative characteristics of patient recruitment in 4 clinical trials with successful recruitment.Results and discussion. Despite the uniqueness of each protocol, the set of patients has its own patterns common to all clinical studies. It was studied, in particular, that the integrative assessment of the preliminary recruitment of patients by the researcher of the clinical center is not associated with an objective pool of patients and affects the rate of patient recruitment and targeted patient recruitment. We found that the number of clinical centers not recruiting patients in each study is at least 30 % of all centers involved. Three patient recruitment rates have also been identified that need to be considered when planning a clinical trial.Conclusion. We have identified patterns in patient recruitment that will help in planning clinical trials.
Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial
Authors: Lebedeva A. I. , Afanasiev S. A. , Gareev E. M. , Kondratieva D. S. , Musina L. A. , Popov S. V. , Prusakov A. V. , Yashin A. V. , Ponamarev V. S. , Radnatarov V. D. 
Published: September 2023

Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, as well as to reveal the possible mechanisms of cellular regeneration.Materials and methods. The muscular wall of the heart of rats was subjected to cryodestruction. After 45 days, the rats of the main group were intramyocardially injected with a suspension of allogeneic biomaterialinto the area of the affected myocardium, and the rats of the control group were injected with saline.Results and discussions. In the experimental group, there was a regression of the formed fibrous connective tissue, chemoattraction of progenitor cells, their differentiation and integration into the myocardium. The thickness of the muscular part of the wall of the left ventricle was three orders of magnitude higher than in the control group.Conclusion. Analysis of the results of the study indicates that the heart in adult mammals has a powerful regenerative reserve. It is likely that, based on the use of DAB, a protocol can be developed that allows the restoration of the heart muscle even in conditions of already developed fibrous degeneration.
Development of Injectable Formulation of 4’-O-benzyloxycarbonyl-etoposide Derivative Based on Human Serum Albumin for the Chemotherapy of Breast Cancer
Authors: Kovshova T. S. , Boiko S. A. , Merkulova M. A. , Osipova N. S. , Moiseeva N. I. , Malinovskaya Ju. A. , Mantrov S. N. , Gelperina S. E. 
Published: September 2023

Introduction. One of the promising strategies for the development of injectable formulations of poorly water-soluble drugs is the preparation of their nanosuspensions stabilized with albumin. A well-known example of the successful implementation of this technology is Abraxane® (nanoparticle albumin-bound paclitaxel). In the present study, this approach is used for the development of the injectable formulation of a hydrophobic etoposide prodrug.Aim. Development of the injectable formulation of a novel 4'-О-benzyloxycarbonyl derivative of etoposide (ETP-cbz) based on human serum albumin and evaluation of its cytotoxicity against breast carcinoma cells (BC).Materials and methods. The structure of ETP-cbz was confirmed by NMR spectroscopy and elemental analysis; log P was calculated in silico using Molinspiration Cheminformatics. The ETP-cbz-HSA nanoparticles were prepared by high pressure homogenization. The particle size, size distribution, and disintegration concentration were evaluated by dynamic light scattering (DLS) and atomic force microscopy (AFM). The contents of ETP-cbz and albumin in the formulation were determined by HPLC. The conversion ETP-cbz-HSA to etoposide was studied in a model medium in the presence of esterase. The cytotoxicity of ETP-cbz-HSA compared to etoposide and free ETP-cbz was assessed on BC cells (HBL-100 and MCF-7) using a colorimetric MTT assay.Results and discussion. ETP-cbz exhibited higher hydrophobicity as compared to the etoposide (log P 2.42 vs 0.7, respectively). Due to easy cleavage of the carbonate bond in the presence of esterase, ETP-cbz can be considered an etoposide prodrug. The ETP-cbz-containing HSA nanoparticles prepared by a high-pressure homogenization technique had the particle size of 110 ± 9 nm (DLS) and a low disintegration concentration of 3.0 ± 0.1 μg/mL. The drug content was 1.75 mg/mL. The nanoformulation demonstrated high cytotoxic activity in vitro against MCF-7 and HBL-100 cells that was comparable to the activity of substances etoposide and ETP-cbz.Conclusion. The obtained nanoformulation of etoposide prodrug based on albumin, suitable for injection, showed high cytotoxicity against breast cancer cells in vitro and deserves further study to assess the possibility of its use in breast cancer chemotherapy.
Analisis kemampuan numerasi matematis siswa dalam menyelesaikan masalah TIMSS ditinjau dari gender
Authors: Alfarisi Alfarisi , Suryaningrum Christine Wulandari , Firdaus Hana Puspita Eka 
Published: September 2023

Kemampuan numerasi adalah keterampilan dalam menggunakan, memahami, serta menganalisis matematika untuk mengerjakan masalah dalam kehidupan sehari-hari. Penelitian memiliki tujuan mencari tahu perbedaan kemampuan numerasi matematika siswa dalam mengerjakan masalah TIMSS (Tren in InternasionalÂ Mathematics and Science Study) dilihat dari gender yaitu pengkatagorian berdasarkan jenis kelamin. Metode penelitian ini menggunakan penelitian kualitatif deskriptif. Berdasarkan studi pendahuluan dari 28 siswa hanya terdapat 4 siswa yang mampuÂ mengerjakan masalah TIMSS. Oleh karena itu, subjek yang terpilih sebanyak 4 siswa kelas VIII E salah satu SMP Â di kabupaten Jember provinsi Jawa Timur dengan 2 siswa laki-laki serta 2 siswa perempuan. Instrumen menggunakan 2 soal masalah TIMSS terkait pemecahan masalah di kehidupan sehari-hari, wawancara, serta dokumentasi. Selain itu, analisis data menggunakan pertama reduksi data, kedua penyajian data, serta terakhir penarikan kesimpulan, dilanjutkan pengujian kesahihan data menggunakan triangulasi sumber. Peneliti memilih subjek berlandaskan indikator kemampuan numerasi dari 4 siswa sebagai subjek penelitian tersebut menunjukkan kemampuan numerasi siswa laki-laki lebih unggul daripada siswa perempuan. Perbedaan kemampuan numerasi siswa dilihat berdasarkan 3 komponen indikator kemampuan numerasi. Perbedaan dikarenakan kemampuan penalaran siswa laki-laki lebih baik dibandingkan siswa perempuan dalam mengerjakan masalah di kehidupan nyata. Siswa laki-laki juga lebih unggul dalam pemahaman konsep mengerjakan masalah matematika.Â Kata kunci: Kemampuan Numerasi ; Masalah TIMSS ; Gender
Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn
Authors: Keppeke Gerson Dierley , Chang Chia-Chun , Zhang Ziheng , Liu Ji-Long 
Published: September 2023

Introduction: Inosine monophosphate dehydrogenase 1 (IMPDH1) is a critical enzyme in the retina, essential for the correct functioning of photoreceptor cells. Mutations in IMPDH1 have been linked to autosomal dominant retinitis pigmentosa subtype 10 (adRP-10), a genetic eye disorder. Some of these mutations such as the Asp226Asn (D226N) lead to the assembly of large filamentous structures termed cytoophidia. D226N also gives IMPDH1 resistance to feedback inhibition by GDP/GTP. This study aims to emulate the adRP-10 condition with a long-term expression of IMPDH1-D226N in vitro and explore cytoophidium assembly and cell survival. We also assessed whether the introduction of an additional mutation (Y12C) to disrupt the cytoophidium has an attenuating effect on the toxicity caused by the D226N mutation.Results: Expression of IMPDH1-D226N in HEp-2 cells resulted in cytoophidium assembly in ∼70% of the cells, but the presence of the Y12C mutation disrupted the filaments. Long-term cell survival was significantly affected by the presence of the D226N mutation, with a decrease of ∼40% in the cells expressing IMPDH1-D226N when compared to IMPDH1-WT; however, survival was significantly recovered in IMPDH1-Y12C/D226N, with only a ∼10% decrease when compared to IMPDH1-WT. On the other hand, the IMPDH1 expression level in the D226N-positive cells was &lt;30% of that of the IMPDH1-WT-positive cells and only slightly higher in the Y12C/D226N, suggesting that although cell survival in Y12C/D226N was recovered, higher expression levels of the mutated IMPDH1 were not tolerated by the cells in the long term.Conclusion: The IMPDH1-D226N effect on photoreceptor cell survival may be the result of a sum of problems: nucleotide unbalance plus a toxic long-life cytoophidium, supported by the observation that by introducing Y12C in IMPDH1 the cytoophidium was disrupted and cell survival significantly recovered, but not the sensibility to GDP/GTP regulation since higher expression levels of IMPDH1-D226N were not tolerated.
The long-term safety and effectiveness of the loop technique in left ventricular lead dislocation
Authors: Dong Mengya , Liang Chenyuan , Cheng Gong 
Published: September 2023

ObjectivesCardiac resynchronization therapy (CRT) is a well-established method that improves the clinical symptoms and long-term prognosis of specific heart failure (HF) patients by restoring systolic synchronicity and enhancing myocardial function. However, the high rate of intraoperative and postoperative left ventricular (LV) lead dislocation limits its application to a great extent. The aim of this study was to demonstrate the long-term safety and effectiveness of a new approach named the loop technique for patients who experience repeated intraoperative transvenous LV lead dislocations during CRT.MethodsThe current study was a single-centre, prospective, nonrandomized controlled trial. Forty-four HF patients who underwent CRT were included. All patients were followed to death or 3 years.ResultsAmong 44 HF patients, 36 underwent the traditional operation, and 8 underwent the loop technique due to repeated intraoperative LV lead dislocations. Intergroup comparison revealed no significant differences between the two groups with respect to most preoperative indices, intraoperative pacing and sensing parameters. At the end of the 3-year follow-up, 4 (11.1%) patients in the traditional operation group and 2 (25.0%) patients in the loop technique group had died. There was no significant difference in the mortality rate (P = 0.30). No complications related to this new technique were observed, such as intracoronary thrombosis, infection or dislocation. Intergroup comparison showed no significant difference in the New York Heart Association (NYHA) class, echocardiography indices, N-terminal pro brain natriuretic peptide (NT-proBNP) level or pacemaker programming parameters.ConclusionsThe loop technique is a safe and effective alternative method for patients who experience repeated intraoperative transvenous LV lead dislocations during CRT.
Impact of pulmonary artery pressure on recurrence after catheter ablation in patients with atrial fibrillation
Authors: Choi Yun Young , Choi Jong-Il , Jeong Joo Hee , Lee Hyoung Seok , Kim Yun Gi , Kim Mi-Na , Roh Seung-Young , Shim Jaemin , Kim Jin Seok , Park Seong-Mi , Kim Young-Hoon 
Published: September 2023

BackgroundThe pulmonary veins play a major role in the pathogenesis of atrial fibrillation (AF) and may be affected by cardiac remodeling due to pulmonary vascular dysfunction. It remains to be determined whether pulmonary artery pressure (PAP) is associated with the recurrence of AF after radiofrequency catheter ablation (RFCA).MethodsConsecutive patients with paroxysmal and persistent AF who underwent RFCA, including wide circumferential pulmonary vein isolation, were analyzed. Systolic PAP was measured using transthoracic echocardiography, and clinical outcomes were compared between patients with PAP &lt;35 mmHg and those with PAP ≥35 mmHg.ResultsAmong 2,379 patients (mean age 56.7 ± 10.6 years, 77% men), 1,893 (79.6%) had PAP &lt;35 mmHg and 486 (20.4%) had PAP ≥35 mmHg. During the median follow-up of 25.4 months, in patients with paroxysmal AF (n = 1,294), the recurrence rate was significantly greater in the PAP ≥35 mmHg group than in the PAP &lt;35 mmHg group (35.1% vs. 23.8%, log-rank p = 0.008). However, in patients with persistent AF (n = 1,085), the recurrence rate was not significantly different between the two groups (52.2% vs. 49.7%, log-rank p = 0.409). Multivariate analysis using Cox regression showed that PAP ≥35 mmHg was significantly associated with clinical recurrence (hazard ratio 1.19, 95% confidence interval 1.02–1.40, p = 0.027).ConclusionThis study showed that a higher PAP was associated with an increased risk of recurrence after RFCA in patients with paroxysmal AF, suggesting a mechanism by which a pulmonary vascular pathology may cause impairment of the pulmonary veins and remodeling of the left atrium.
Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
Authors: Andersen Thomas , Ueland Thor , Aukrust Pål , Nilsen Dennis W.T. , Grundt Heidi , Staines Harry , Pönitz Volker , Kontny Frederic 
Published: September 2023

BackgroundExtracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, and P1NP has not been investigated in acute chest pain. The objective of the current study was to assess the role of P1NP in undifferentiated acute chest pain of suspected coronary origin.Methods and results813 patients from the Risk in Acute Coronary Syndromes study were included. This was a single-center study investigating biomarkers in consecutively enrolled patients with acute chest pain of suspected coronary origin, with a follow-up for up to 7 years. Outcome measures were a composite endpoint of all-cause death, new MI or stroke, as well as its individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. In multivariable Cox regression analysis, quartiles of P1NP were significantly associated with the composite endpoint at 1 year of follow-up with a hazard ratio for Q4 of 1.82 (95% CI, 1.12–2.98). There was no other significant association with outcomes at any time points.ConclusionP1NP was found to be an independent biomarker significantly associated with adverse clinical outcome at one year in patients admitted to hospital for acute chest pain of suspected coronary origin. This is the first report in the literature on the prognostic value of P1NP in this clinical setting.Clinicaltrials.ygov IdentifierNCT00521976.