bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Trap‐Capture‐Kill Antibacterial System for Infected Microenvironment Improvement and Vascularized Bone Regeneration via Magnetic Thermotherapy
Authors: Zhao Yanan , Hu Liangcong , Dai Honglian , Zhuang Pengzhen , Huang Kai , Hou Wen , Liu Jiawei , Tu Rong , Goto Takashi 
Published: March 2023

AbstractInfected bone defect has gradually become a disastrous complication in orthopedic surgery because of the bacterial biofilm formation both on the surface of the implants and surrounding tissues, which will cause antibiotic resistance and weak postoperative osseointegration. Herein, drug‐loaded hollow mesoporous ferrite nanoparticles coated by gelatin (GM/HMFNs) with pomegranate structure are prepared and compounded into calcium magnesium phosphate cement (MCPC) as a Trap‐Capture‐Kill system to kill bacteria and inhibit biofilm formation efficiently. Under the action of alternating magnetic field (AMF), MCPC/GM/HMFNs/Drug composites exhibit acute magnetic hyperthermal capacity and recruit the free bacteria. Then, the permeability of bacterial cell membrane is increased via reactive oxygen species (ROS) damage of nano‐MgO and HMFNs, providing channels through which vancomycin (Van) and ciprofloxacin (CPFX) encapsulated in GM/HMFNs can penetrate. Subsequently, the bacteria are efficiently killed under the synergetic cooperation of magnetothermal effect, ROS damage, and adsorption damage of nano‐MgO, and the bioactive ions and drugs. The antibacterial system also presents outstanding pro‐osteogenesis and pro‐angiogenic capacity in vitro. And it promotes the vascularized bone regeneration of infective femoral defect in SD rats in vivo, providing promising potential for the treatment of infected bone defects through magnetothermal therapy.
Reversible Room Temperature Brittle‐Plastic Transition in Ag2Te0.6S0.4 Inorganic Thermoelectric Semiconductor
Authors: Wang Yuechu , Li Airan , Hu Huiping , Fu Chenguang , Zhu Tiejun 
Published: March 2023

AbstractInorganic semiconductors with superior plasticity are highly desired in current flexible electronics, which however are rarely discovered owing to their intrinsic covalent and ionic bonds. The Ag2Te0.6S0.4 semiconductor with an amorphous phase has recently been reported to exhibit plastic deformability. In this study, the reversible brittle‐plastic transition is found in this inorganic semiconductor, and the plasticity of the Ag2Te0.6S0.4 sample is highly related to the phase structures. The Ag2Te0.6S0.4 with a monoclinic phase exhibits a brittle behavior, while the one with cubic‐crystalline/amorphous structure shows exceptional plasticity with a compressive strain of over 80%. Significantly, the reversible plastic‐brittle transition in Ag2Te0.6S0.4 inorganic semiconductor can be achieved by simple heat treatment. Besides the plasticity, the cubic‐crystalline/amorphous Ag2Te0.6S0.4 composites also possess good thermoelectric performance. This study uncovers the influence of phase structure on the mechanical properties of Ag2Te0.6S0.4 and realizes the reversible brittle‐plastic transition, facilitating its prospective application in flexible/wearable electronics.
Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease
Authors: Zhang Yinfeng , Wang Tingting , Sun Meng , Song Yueyue , Huang Xinyuan , Zhang Shutian , Yang Jun , Zhang Jinfeng 
Published: March 2023

AbstractInflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with a variety of painful clinical manifestations and an increased risk of cancerization or death, has become an emerging challenge to global healthcare due to its rapidly increasing incidence. At present, there is no efficient cure against IBD because of the elusive etiology and pathogenesis of IBD. Therefore, the development of alternative therapeutic strategies with positive clinical efficacy and reduced side effects is urgently needed. In recent years, the great prosperity of nanomedicine promoted by a variety of advanced nanomaterials is redefining more attractive and promising therapeutic strategies for IBD owing to their advantages in the physiological stability, bioavailability, and targeting of inflammatory sites. In this review, firstly the basic characteristics of healthy and inflammatory intestinal microenvironments are presented. Then, different administration routes and targeting strategies of nanotherapeutics for IBD treatment are reviewed. Subsequently, a specific focus is placed on the introduction of nanotherapeutic treatments based on different IBD pathogenesis. Finally, some future challenges and perspectives of the currently developed nanomedicines for IBD treatment are provided. It is believed that the above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry and pharmaceutics.
Functional Titanium Substrates Synergetic Photothermal Therapy for Enhanced Antibacterial and Osteogenic Performance via Immunity Regulation
Authors: Xu Kun , Li Ke , He Ye , Li Xuan , Lin Chuanchuan , Wu Jing , Liu Shaopeng , Ding Yao , Yang Yulu , Gou Shuangquan , Liu Peng , Cai Kaiyong 
Published: March 2023

AbstractImplant‐associated infections (IAIs) significantly impair the integration between titanium (Ti) implants and bone tissues. Bacteria colonized on the surface of the implant can induce innate immune suppression of the host to resist clearance. Herein, an interfacial functionalization strategy is employed to introduce FeIIITA nanoparticles (NPs) and acetyl Bletilla striata polysaccharide (acBSP) on the Ti substrate to obtain the Ti‐TF‐acBSP system. Under near‐infrared (NIR) irradiation, the hyperthermal effect induced by FeIIITA NPs directly killed bacteria. Meanwhile, macrophages are induced by acBSP to polarize into pro‐inflammatory M1 phenotype, which enhanced the phagocytosis ability of macrophages and activated host innate immunity. Moreover, the asBSP instructed macrophages to secrete pro‐osteogenic cytokine, which promoted osteogenic differentiation of MSCs. The results of the animal experiment in vivo confirmed that the Ti‐TF‐acBSP implant effectively eliminated bacterial infection under NIR irradiation, enhanced the expression of pro‐inflammatory cytokine, and induced the production of bone‐forming related factors. In a word, the functionalized Ti implant not only have a direct bactericidal effect but also regulate macrophage polarization as well as macrophage‐mediated bactericidal and osteogenic effect. The strategy of combining photothermal therapy with immunoregulation will present a potential candidate for the development of novel antibacterial orthopedic devices.
Tough, Recyclable, and Degradable Elastomers for Potential Biomedical Applications
Authors: Guo Xiwei , Liang Jiaheng , Wang Zhifen , Qin Jianliang , Zhang Qi , Zhu Shiping , Zhang Kun , Zhu He 
Published: March 2023

AbstractElastomers have many industrial, medical and commercial applications, however, their huge demand raises an important question of how to dispose of the out‐of‐service elastomers. Ideal elastomers that are concurrently tough, recyclable, and degradable are in urgent need, but their preparation remains a rigorous challenge. Herein, a polycaprolactone (PCL) based polyurethane elastomer is designed and prepared to meet this demand. Owing to the presence of dynamic coordination bond and the occurrence of strain‐induced crystallization, the obtained elastomer exhibits a high toughness of ≈372 MJ m−3 and an unprecedented fracture energy of ≈646 kJ m−2, which is much higher than natural rubber (≈50 MJ m−3 for toughness and ≈10 kJ m−2 for fracture energy). In addition, the elastomer can be recycled at least three times using solvent without losing its mechanical properties and can be degraded by lipase in ≈2 months. Finally, biological experiments demonstrate that the elastomer possesses good biocompatibility and can facilitate wound healing in mice when used as sutures. It is believed that the obtained elastomer meets the requirements for next‐generation elastomers and is expected to be used in emerging fields such as biomedicine, flexible electronics, robotics and beyond.
Electrolytes with Solvating Inner Sheath Engineering for Practical Na–S Batteries
Authors: Guo Dong , Wang Jiaao , Lai Tianxing , Henkelman Graeme , Manthiram Arumugam 
Published: March 2023

AbstractSodium–sulfur (Na–S) batteries with durable Na‐metal stability, shuttle‐free cyclability, and long lifespan are promising to large‐scale energy storages. However, meeting these stringent requirements poses huge challenges with the existing electrolytes. Herein, a localized saturated electrolyte (LSE) is proposed with 2‐methyltetrahydrofuran (MeTHF) as an inner sheath solvent, which represents a new category of electrolyte for Na–S system. Unlike the traditional high concentration electrolytes, the LSE is realized with a low salt‐to‐solvent ratio and low diluent‐to‐solvent ratio, which pushes the limit of localized high concentration electrolyte (LHCE). The appropriate molecular structure and solvation ability of MeTHF regulate a saturated inner sheath, which features a reinforced coordination of Na+ to anions, enlarged Na+‐solvent distance, and weakened anion‐diluent interaction. Such electrolyte configuration is found to be the key to build a sustainable interphase and a quasi‐solid–solid sulfur redox process, making a dendrite‐inhibited and shuttle‐free Na–S battery possible. With this electrolyte, pouch cells with decent cycling performance under rather demanding conditions are demonstrated.
Rhodium(III‐Catalyzed C8‐Selective C−H Alkenylation and Alkylation of 1, 2, 3, 4‐Tetrahydroquinolines with Styrenes and Allylic Alcohols
Authors: Yang Ji , Chen Changjun , Zhao Haoqiang , Li Bohan , He Zhenni , Xu Lijin , Shi Qian 
Published: March 2023

AbstractRh(III)‐catalyzed chelation‐assisted C8‐selective C−H alkenylation and alkylation of 1,2,3,4‐tretrahydroquinolines with styrenes and allylic alcohols have been realized. The cationic Rh(III) catalytic system in combination with a catalytic amount of copper acetate uses oxygen as the terminal oxidant and catalyzes the stereoselective C8‐alkenylation of 1,2,3,4‐tetrahydroquinolines with styrenes to give the corresponding products in 56–93% yields with wide substrate scope and broad functional group compatibility. The reaction can be scaled up. Moreover, this protocol can be extended to the C8‐alkylation of 1,2,3,4‐tetrahydroquinolines with allylic alcohols, providing access to various 8‐(3‐oxoalkyl)‐1,2,3,4‐tetrahydroquinolines in 77–90% yields. The selection of N‐directing group is essential for catalysis, and the readily installable and removable N‐(2‐pyrimidyl) group proves to be optimal choice. Preliminary mechanistic studies are performed to gain insights into the reaction mechanism.magnified image
Synthesis of 2‐Aminopyrrolo[1,2‐b]pyridazines via Gold(I)‐Catalyzed Chemoselective Hydroamination/Hydroarylation Cascade of 1,3‐Diynamides with 1‐Aminopyrroles
Authors: Wang Junying , Du Jianghui , Wang Tao 
Published: March 2023

AbstractThe synthesis of 2‐aminopyrrolo[1,2‐b]pyridazines from 1,3‐diynamides and 1‐aminopyrroles via gold(I)‐catalyzed chemoselective hydroamination/hydroarylation cascade was described. 26 examples were conducted to explore the scope of the substrates. A plausible reaction mechanism was also proposed. In addition, the fluorescence properties both in solutions and in the solid states of the resulting products were investigated.magnified image
The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease
Authors: Ge Xuejun , Xue Gang , Ding Yan , Li Ran , Hu Kaining , Xu Tengjiao , Sun Ming , Liao Wang , Zhao Bin , Wen Chuangyu , Du Jie 
Published: March 2023

AbstractThe nuclear N6‐methyladenosine (m6A) reader YT521‐B homology‐domain‐containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity. However, little is known about its biological functions in intestinal‐resident macrophages and inflammatory bowel disease (IBD). Herein, it is demonstrated that macrophage‐specific depletion or insufficiency of YTHDC1 accelerates IBD development in animal models. On the molecular basis, YTHDC1 reduction in IBD‐derived macrophages is attributed to Zinc finger protein 36 (ZFP36)‐induced mRNA degradation. Importantly, transcriptome profiling and mechanistic assays unveil that YTHDC1 in macrophages regulates Ras homolog family member H (RHOH) to suppress inflammatory responses and fine‐tunes NME nucleoside diphosphate kinase 1 (NME1) to enhance the integrity of colonic epithelial barrier, respectively. Collectively, this study identifies YTHDC1 as an important factor for the resolution of inflammatory responses and restoration of colonic epithelial barrier in the setting of IBD.
The pollen virome: A review of pollen‐associated viruses and consequences for plants and their interactions with pollinators
Authors: Fetters Andrea M. , Ashman Tia‐Lynn 
Published: March 2023

AbstractThe movement of pollen grains from anthers to stigmas, often by insect pollinator vectors, is essential for plant reproduction. However, pollen is also a unique vehicle for viral spread. Pollen‐associated plant viruses reside on the outside or inside of pollen grains, infect susceptible individuals through vertical or horizontal infection pathways, and can decrease plant fitness. These viruses are transferred with pollen between plants by pollinator vectors as they forage for floral resources; thus, pollen‐associated viral spread is mediated by floral and pollen grain phenotypes and pollinator traits, much like pollination. Most of what is currently known about pollen‐associated viruses was discovered through infection and transmission experiments in controlled settings, usually involving one virus and one plant species of agricultural or horticultural interest. In this review, we first provide an updated, comprehensive list of the recognized pollen‐associated viruses. Then, we summarize virus, plant, pollinator vector, and landscape traits that can affect pollen‐associated virus transmission, infection, and distribution. Next, we highlight the consequences of plant–pollinator–virus interactions that emerge in complex communities of co‐flowering plants and pollinator vectors, such as pollen‐associated virus spread between plant species and viral jumps from plant to pollinator hosts. We conclude by emphasizing the need for collaborative research that bridges pollen biology, virology, and pollination biology.
Carpal kinematics and morphological correlates of wrist ulnar deviation mobility in nonhuman anthropoid primates
Authors: Orr Caley M. , Atkinson Richard , Ernewein Jamie , Tocheri Matthew W. 
Published: March 2023

AbstractObjectivesPrimates employ wrist ulnar deviation during a variety of locomotor and manipulative behaviors. Extant hominoids share a derived condition in which the ulnar styloid process has limited articulation or is completely separated from the proximal carpals, which is often hypothesized to increase ulnar deviation range of motion. Acute angulation of the hamate's triquetral facet is also hypothesized to facilitate ulnar deviation mobility and mechanics. In this study, we test these longstanding ideas.MethodsThree‐dimensional (3D) carpal kinematics were examined using a cadaveric sample of Pan troglodytes, Pongo sp., and five monkey species. Ulnar styloid projection and orientation of the hamate's triquetral facet were quantified using 3D models.ResultsAlthough carpal rotation patterns in Pan and Pongo were uniquely similar in some respects, P. troglodytes exhibited overall kinematic similarity with large terrestrial cercopithecoids (Papio and Mandrillus). Pongo, Macaca, and Ateles had high wrist ulnar deviation ranges of motion, but Pongo did this via a unique mechanism. In Pongo, the triquetrum functions as a distal carpal rather than part of the proximal row. Ulnar styloid projection and wrist ulnar deviation range of motion were not correlated but ulnar deviation range of motion and the triquetrohamate facet orientation were correlated.ConclusionsIncreased ulnar deviation mobility is not the function of ulnar styloid withdrawal in hominoids. Instead, this feature probably reduces stress on the ulnar side wrist or is a byproduct of adaptations that increase supination. Orientation of the hamate's triquetral facet offers some potential to reconstruct ulnar deviation mobility in extinct primates.
Synthesis of vanillin derivatives with 1,2,3‐triazole fragments and evaluation of their fungicide and fungistatic activities
Authors: Gazolla Poliana A. R. , de Aguiar Alex R. , Costa Maria C. A. , Oliveira Osmair V. , Costa Adilson V. , da Silva Cleiton M. , do Nascimento Claudia J. , Junker Jochen , Ferreira Rafaela S. , de Oliveira Fabrício M. , Vaz Boniek G. , do Carmo Paulo H. F. , Santos Daniel A. , Ferreira Márcia M. C. , Teixeira Róbson R. 
Published: March 2023

AbstractVanillin is the main component of natural vanilla extract and is responsible for its flavoring properties. Besides its well‐known applications as an additive in food and cosmetics, it has also been reported that vanillin can inhibit fungi of clinical interest, such as Candida spp., Cryptococcus spp., Aspergillus spp., as well as dermatophytes. Thus, the present work approaches the synthesis of a series of vanillin derivatives with 1,2,3‐triazole fragments and the evaluation of their antifungal activities against Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans, Cryptococcus gattii, Trichophyton rubrum, and Trichophyton interdigitale strains. Twenty‐two vanillin derivatives were obtained, with yields in the range of 60%–91%, from copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC) click reaction between two terminal alkynes prepared from vanillin and different benzyl azides. In general, the evaluated compounds showed moderate activity against the microorganisms tested, with minimum inhibitory concentration (MIC) values ranging from 32 to >512 µg mL−1. Except for compound 3b against the C. gattii R265 strain, all vanillin derivatives showed fungicidal activity for the yeasts tested. The predicted physicochemical and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties for the compounds indicated favorable profiles for drug development. In addition, a four‐dimensional structure‐activity relationship (4D‐SAR) analysis was carried out and provided useful insights concerning the structures of the compounds and their biological profile. Finally, molecular docking calculations showed that all compounds bind favorably at the lanosterol 14α‐demethylase enzyme active site with binding energies ranging from –9.1 to –12.2 kcal/mol.
Feeling intimidated and uncomfortable: Established and exacerbated educational inequities experienced by black parents of autistic children
Authors: Koffer Miller Kaitlin H. , Cooper Dylan S. , Ventimiglia Jonas C. , Shea Lindsay L. 
Published: March 2023

AbstractThere are clear racial disparities that impact the education system. To capture the educational experiences of family members of Black autistic children as compared to white autistic children in the United States (US), a mixed methods design was implemented and included semi‐structured interviews with family members of children between the ages of 5–12 who participated in a survey. The survey responses were used as attribute data. Twenty‐nine interviews were conducted with parents of school‐age autistic children. Findings from this study highlight challenges experienced by parents including education service use and engagement during the COVID‐19 pandemic, engaging with school personnel, and securing accommodations. The findings from this study illuminate the disparities experienced by Black parents of autistic children directly reported by the parents themselves in comparison to white parents. The themes elucidated in this study have implications for policy, practice, and research to ensure equity in educational settings for Black autistic students and their families.
The road (not) taken: Principals' perceptions of at‐risk pupils' participation in collective decision‐making
Authors: Gazit Matan , Perry‐Hazan Lotem 
Published: March 2023

AbstractThe United Nations Convention on the Rights of the Child anchors children's right to participate in decision‐making. This right refers to decisions at the individual level as well as collective decisions taken by a group of children. Various studies have indicated that youth from disadvantaged backgrounds face high barriers to participation in collective decision‐making and thus have fewer opportunities to enjoy the educational and developmental benefits of such participation. This study explored school principals' perceptions of at‐risk youths' participation in collective decision‐making in schools. Specifically, it analysed differences between the perceptions of principals who had established participatory frameworks and those who had not. The research design drew on interviews with 18 principals who manage high schools for at‐risk youth in Israel. All interviewed principals acknowledged the potential cultural mismatch between the dominant models of pupil councils and the culture of at‐risk youth. Principals who had established participatory frameworks viewed participation as a gradual process, trusting their pupils' capacity to attain higher levels of participation even if participatory activities did not come as ‘second nature’ to them. However, principals who did not institute such frameworks viewed their pupils' participation as an ‘all‐or‐nothing’ enterprise, inappropriate for at‐risk youth. Fulfilling participation rights in schools for at‐risk youth requires efforts to adapt the participatory capital to the pupils' background. The principals' perceptions of the participation process and of their pupils were intertwined with their willingness to engage in such adaptations and take the less‐travelled road of participatory practices in schools for at‐risk youth.
Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Authors: Voskarides Konstantinos , Giannopoulou Nefeli , Eid Rasha , Parperis Konstantinos , Chatzittofis Andreas 
Published: March 2023

AbstractBackgroundSeveral studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes.MethodsAll registered single nucleotide polymorphisms (SNPs) in the Genome‐wide association studies (“GWAS catalog”) having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders’ associated SNPs. Analysis was performed by the LDtrait and LDhap bioinformatics tools.ResultsMultiple chromosomal regions have been detected containing rheumatic/endocrine diseases’ predisposing SNPs and psychiatric disorders’ predisposing SNPs. The genetic haplotypes have been constructed for some of these genetic regions. Six of the autoimmune rheumatic and endocrine diseases examined here share a common haplotype with psychiatric diseases at the HLA locus 6p21‐22.ConclusionOur study shows that autoimmune diseases and psychiatric diseases are genetically linked. Genetic haplotypes have been constructed, showing in detail this genetic linkage.