bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of plug-based versus suture-based vascular closure for large-bore arterial access: a collaborative meta-analysis of observational and randomized studies
Authors: Dumpies Oliver , Jobs Alexander , Obradovic Danilo , van Wiechen Maarten , Hartung Philipp , Rotta detto Loria Johannes , Wilde Johannes , Majunke Nicolas , Kiefer Philipp , Noack Thilo , Thiele Holger , van Mieghem Nicolas , Desch Steffen , Abdel-Wahab Mohamed 
Published: February 2023

Abstract
Background
Large-bore arteriotomies can be percutaneously closed with suture-based or plug-based vascular closure device (VCD) strategies. The efficacy of both techniques remains controversial.

Aims
We conducted a meta-analysis of comparative studies between both VCD strategies, focusing on the most commonly applied VCDs (MANTA and ProGlide).

Methods
We searched MEDLINE, the Cochrane Central Register of Controlled Trials and Google scholar for observational studies (OS) and randomized controlled trials (RCT) comparing vascular closure with the MANTA-based and the ProGlide-based technique. The principal endpoint of this analysis was access-site related vascular complications. Both study types were analyzed separately.

Results
Access-site related vascular complications were less frequent after vascular closure with the MANTA technique in the analysis of OS (RR 0.61 [95%CI 0.43–0.89], p = 0.01, I2 = 0%), but more frequent in the analysis of RCT data (RR 1.70 [95%CI 1.16–2.51], p = 0.01, I2 = 0%). Both data sets provided no significant difference between the VCD techniques in terms of overall bleeding events (OS: RR 0.57 [95%CI 0.32–1.02], p = 0.06, I2 = 70%; and RCT: RR 1.37 [95%CI 0.82–2.28], p = 0.23, I2 = 30%). RCT data showed that endovascular stenting or vascular surgery due to VCD failure occurred more often after MANTA application (RR 3.53 [95%CI 1.07–11.33], p = 0.04, I2 = 0%).

Conclusions
While OS point to favorable outcomes for large-bore vascular closure with the MANTA-based technique, RCT data show that this strategy is associated with more access-site related vascular complications as well as endovascular stenting or vascular surgery due to device failure compared with the ProGlide-based technique.

Graphical abstract
Systematic review to estimate the prevalence of inflammatory rheumatic diseases in Germany
Authors: Albrecht Katinka , Binder Sebastian , Minden Kirsten , Poddubnyy Denis , Regierer Anne C. , Strangfeld Anja , Callhoff Johanna 
Published: February 2023

Abstract
Objective
This study aimed to update the prevalence estimates of inflammatory rheumatic diseases (IRD) in Germany.

Methods
A systematic literature search in PubMed and Web of Science (last search 08 November 2022) identified original articles (regional and nationwide surveys and claims data analyses for arthritides, connective tissue diseases, and vasculitides) on prevalences for the period 2014–2022. Data sources, collection period, case definition, and risk of bias are reported. Prevalences were estimated from available national data, with consideration of international data.

Results
Screening by two authors yielded 263 hits, of which 18 claims data analyses and 2 surveys met the inclusion criteria. Prevalences ranged from 0.42 to 1.85% (rheumatoid arthritis), 0.32–0.5% (ankylosing spondylitis), 0.11–0.32% (psoriatic arthritis), 0.037–0.14% (systemic lupus erythematosus), 0.07–0.77% (Sjögren’s disease/sicca syndrome), 0.14–0.15% (polymyalgia rheumatica, ≥ 40 years), 0.04–0.05% (giant cell arteritis, ≥ 50 years), and 0.015–0.026% (ANCA-associated vasculitis). The risk of bias was moderate in 13 and high in 7 studies. Based on the results, we estimate the prevalence of IRD in Germany to be 2.2–3.0%, which corresponds to approximately 1.5–2.1 million affected individuals. The prevalence of juvenile idiopathic arthritis was reported to be around 0.10% (0.07–0.10%) of 0–18-year-olds, corresponding to about 14,000 children and adolescents in Germany.

Conclusion
This systematic review shows an increase in the prevalence of IRD in Germany, which is almost exclusively based on claims data analyses. In the absence of multistage population studies, the available data are, overall, uncertain sources for prevalence estimates, with a moderate to high risk of bias.
Periprosthetic knee infection in octogenarians: a single institution experience at midterm outcome
Authors: Karczewski Daniel , Schönnagel Lukas , Hipfl Christian , Akgün Doruk , Hardt Sebastian 
Published: February 2023

Abstract
Purpose
Periprosthetic joint infections (PJI) of total knee arthroplasties (TKAs) in the elderly is among the clinically most challenging scenarios given multimorbidity combined with poor bone and soft tissue quality. Despite increasing prevalence, limited is known on PJI among this unique group of patients. As such, this study analyzed PJI characteristics, implant survivorship and non-surgical complications of octogenarians revised PJI for the knee.

Methods
We identified 31 patients that were revised for PJIs of the knee between 2010 and 2019 using a single university-based registry. Mean age was 83 years (range 80–87), 48% were females, and mean BMI was 29 kg/m2. Mean age adjusted Charlson Comorbidity Index was 7, and mean ASA score was 3. Major causative pathogens included Coagulase-negative Staphylococci (26%), Staphylococcus aureus (13%), and Streptococci (13%). Two-stage exchange was performed in 30 patients, permanent resection arthroplasty in one joint. Kaplan–Meier survivorship analyses were performed. Mean follow-up was 4 years.

Results
The 2-year survivorship free of any recurrent PJI was 96%, and there was one PJI relapse noted at 6 months. Moreover, there were three additional revisions for aseptic loosening, and one further revision for fracture. As such, the 2-year survivorship free of any revision was 87%. In addition to the aforementioned revisions, there was one additional plate osteosynthesis for a Vancouver C fracture, resulting in a 79% survivorship free of any reoperation at 2 years. Mean perioperative complication score according to the Clavien–Dindo classification was 2 out of 5. A total of three patients died: one patient 40 days after resection arthroplasty, two others 4 months and 8 months after reimplantation.

Conclusions
Octogenarians revised for PJI of the knee are at low risk of recurrent infection and overall revision at 2 years. However, moderate rates of perioperative complications and mortality at short term must acknowledge before deciding upon procedure.

Level of evidence
Therapeutic level IV.
Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations
Authors: Toyoda Yu , Miyata Hiroshi , Uchida Naohiro , Morimoto Keito , Shigesawa Ryuichiro , Kassai Hidetoshi , Nakao Kazuki , Tomioka Naoko H. , Matsuo Hirotaka , Ichida Kimiyoshi , Hosoyamada Makoto , Aiba Atsu , Suzuki Hiroshi , Takada Tappei 
Published: February 2023

AbstractUric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with hyperuricemia and gout. Several physiologically important urate transporters regulate this water-soluble metabolite in the human body; however, the existence of latent transporters has been suggested in the literature. We focused on the Escherichia coli urate transporter YgfU, a nucleobase-ascorbate transporter (NAT) family member, to address this issue. Only SLC23A proteins are members of the NAT family in humans. Based on the amino acid sequence similarity to YgfU, we hypothesized that SLC23A1, also known as sodium-dependent vitamin C transporter 1 (SVCT1), might be a urate transporter. First, we identified human SVCT1 and mouse Svct1 as sodium-dependent low-affinity/high-capacity urate transporters using mammalian cell-based transport assays. Next, using the CRISPR-Cas9 system followed by the crossing of mice, we generated Svct1 knockout mice lacking both urate transporter 1 and uricase. In the hyperuricemic mice model, serum urate levels were lower than controls, suggesting that Svct1 disruption could reduce serum urate. Given that Svct1 physiologically functions as a renal vitamin C re-absorber, it could also be involved in urate re-uptake from urine, though additional studies are required to obtain deeper insights into the underlying mechanisms. Our findings regarding the dual-substrate specificity of SVCT1 expand the understanding of urate handling systems and functional evolutionary changes in NAT family proteins.
Predictors of favorable outcome after pyloroplasty for gastroparesis: should response to pyloric dilation or Botox injection be used as a marker of surgical outcome?
Authors: Eriksson Sven E. , Zheng Ping , Morton Scott , Maurer Nicole , Hoppo Toshitaka , Jobe Blair A. , Ayazi Shahin 
Published: February 2023

Abstract
Introduction
Pyloroplasty and gastric peroral endoscopic myotomy (G-POEM) are effective surgeries for gastroparesis. The primary aim of this study was to evaluate outcomes of pyloroplasty and G-POEM in patients with gastroparesis and determine factors associated with favorable outcome. The secondary aim was to assess the utility of clinical response to preoperative pyloric dilation or botulinum toxin injection (Botox) on surgical outcome, a factor conventionally used as a favorable marker.

Methods
There were 204 patients who underwent pyloroplasty (n = 177) or G-POEM (n = 27) for gastroparesis at our institution from 2014 to 2021. Demographic and clinical parameters were analyzed to assess their impact on surgical outcome. A subgroup of patients who had pyloric dilation or Botox injection were assessed separately. Favorable outcome was defined as patient reported complete resolution of the predominant gastroparesis symptom.

Results
Favorable outcome was achieved in 78.4% of patients (pyloroplasty: 79.7% and G-POEM: 70.4%, p = 0.274). Among 61 patients where pre- and postoperative gastric emptying studies (GES) were available, mean 4-hour retention significantly improved from 33.5 to 15.0% (p < 0.001) and 77.0% of patients achieved normalization.
Favorable outcome was not significantly impacted by etiology of gastroparesis (p = 0.120), GERD (p = 0.518), or primary gastroparesis symptom (p = 0.244). Age ≥ 40 was a significant predictor of favorable surgical outcome on multivariate analysis [OR: 2.476 (1.224–5.008), p = 0.012]. Among the patients who had preoperative dilation (n = 82) or Botox injection (n = 46), response to these interventions was not a predictor of favorable surgical outcome (p = 0.192 and 0.979, respectively). However, preoperative Botox injection, regardless of response to injection, was associated with favorable surgical outcome [OR: 3.205 (CI 1.105–9.299), p = 0.032].

Conclusion
Symptomatic improvement after pyloroplasty or G-POEM is independent of etiology of gastroparesis, GERD, and primary symptom. Response to dilation or Botox are not markers of response to surgery. However, patients who receive Botox are 3.2 times more likely to improve postoperatively.

Graphical abstract
Avoiding module capacitance over-dimensioning of Modular Multilevel Converters with constrained and unconstrained modulator-based Model Predictive Control
Authors: Fuchs Simon , Biela Jürgen 
Published: February 2023

AbstractThe power density of Modular Multilevel Converters (MMCs) is often limited by the over-dimensioning of the module capacitance value. This is common because with conventional control schemes, large voltage and energy margins must be included in the MMC design to avoid overvoltages in the module capacitors and saturation effects due to undervoltages in the module capacitors. This paper presents two Model Predictive Control methods that can reduce the necessary voltage and energy margins to a minimum and therefore increase the power density of the MMC system compared to conventionally controlled MMCs. A trade-off between computational effort and module capacitance over-dimensioning is discovered for the proposed constrained MPC. The unconstrained MPC is compared to the constrained MPC and conventional PI control using simulations. Finally, the performance of the unconstrained MPC is experimentally verified with an MMC system prototype and compared to a traditional PI control system.
Investigations of electrical interference of vertical earth rod arrangements
Authors: Fürnschuß Martin , Pack Stephan , Schmautzer Ernst , Hofbauer Franz , Kowatsch Gernot , Dörfler Jürgen , Schürhuber Robert 
Published: February 2023

AbstractFor the reliable and safe operation of electrical installations, the dissipation of natural and human-made electrical currents into the earth is of great importance. In order to safely dissipate such currents into the earth in a well-controlled manner, blank electrical conductors are specifically inserted into the earth and galvanically connected to the electrical installation. The construct of earth-sensitive conductors (earth electrodes) forms the earthing arrangement. Due to the present conductivity of the earth, galvanically separated earth electrodes interfere electrically through mutual transiting currents. This paper shows geometric arrangements of earth electrodes inserted vertically into the earth, including the effects of the electrical interference on the currents dissipated into the earth, (partial) fault voltages, as well as the resistance to earth by means of calculations. The soil layering and the varying electrical conductivity of the layers are also taken into account. In order to verify the calculations, measurements of the resistances to earth of the vertical earth rods were carried out in a substation in construction.
The effect of a convergent transmucosal neck on soft tissues and radiographic outcomes: a 1-year follow-up randomized controlled trial
Authors: Morón-Conejo Belén , Sanz-Sánchez Ignacio , Salido Maria Paz , Martínez-Rus Francisco , Pradíes Guillermo 
Published: February 2023

Abstract
Purpose
The aim of this randomized controlled clinical trial was to evaluate peri-implant marginal bone levels (MBLs) and soft tissue dimension changes 1 year after loading. Patients in the control group received bone-level implants, whereas in the test group, tissue-level implants with a convergent transmucosal neck were used.

Material and methods
MBLs were calculated by measuring the distance from the implant shoulder to the first visible bone-to-implant contact using standardized periapical digital radiographs. Baseline (day of loading) and follow-up digital models obtained with an intraoral scanner were used to quantify the changes in the peri-implant soft tissue dimensions with a best-fit algorithm.

Results
The difference between final and baseline MBLs showed a mean bone loss of 0.16 ± 0.01 mm in the test group (n = 15) and 0.45 ± 0.09 mm in the control group (n = 14) (p > 0.05). Soft tissue contour at the level of the gingival margin (GM) increased by 1.96 ± 2.69 mm in the test group and 0.65 ± 0.42 mm in the control group (p = 0.167). Both groups showed a coronal displacement of the gingival margin with no significant differences among them.

Conclusions
The present study demonstrated peri-implant hard and soft tissues stability at both implant designs with no significant differences 12 months after loading.

Clinical relevance
There is still insufficient scientific evidence to demonstrate the role and advantages of the convergent transmucosal neck on the behavior of the peri-implant soft and hard tissues stability compared to a straight neck in bone-level implants 12 months after loading.
Pneumatic and acoustic suit: multimodal haptic suit for enhanced virtual reality simulation
Authors: Kang Daeseok , Lee Chang-Gyu , Kwon Ohung 
Published: February 2023

AbstractA haptic device provides users with physical feedback to enhance their experience in virtual reality (VR). We developed a multimodal haptic suit, called as Pneumatic and Acoustic (PA) suit, which exhibits high-resolution haptic feedback, and applies high pressure and realistic vibration to a user. The PA suit artificially simulates the sensation of brief and strong collisions such as the impact of an explosion, ball, or fist. The pneumatic actuators, consisting of 40 air bladders, are designed as bellows-type pneumatic devices for vertical inflation. The air bladders are placed on the chest at an equal interval distance of 30 mm for high-resolution feedback. The acoustic actuators use an effective sound signal of a collision similar to realistic vibrations. This study aims to examine the effectiveness of our multimodal haptic suit in improving VR experience of users. The recognition tests clearly show that participants distinguish between the haptic patterns and position of collided virtual objects with the suit. The user study involving a collision of a ball shows that the PA suit transmits the approximate pressure of a real ball collision with artificial haptic feedback. Our receiving ball and explosion VR simulations confirm that the PA suit improves a VR experience depending on the types of actuators and VR contents. The results prove that the PA suit creates distinguishable haptic patterns for guiding a task and improves the VR experience of users with powerful and multimodal haptic feedback hence providing high-quality VR simulation.
The effect of snow depth on movement rates of GPS-collared moose
Authors: Melin M. , Matala J. , Mehtätalo L. , Pusenius J. , Packalen T. 
Published: February 2023

AbstractDuring deep snow conditions, wildlife must balance between minimizing movements to conserve energy while seeking high amounts of browse to gain the energy. Knowledge of how snow begins to hinder their movements is therefore vital when predicting their wintertime behavior. We assessed the phenomenon with moose. Movement data from 122 GPS-collared moose were integrated with snow depth data from designated measurement stations. The effects of increasing snow depths on moose movement rates were then modeled with spline regression. The study was conducted in Finland, between 2009 and 2011. The moose were known for their sex and for the presence of calf at heel. On average, the movement rates decreased sharply until snow depths of ca. 30–40 cm, after which further significant decreases were not seen. The movement rates decreased from several kilometers per day to less than 500 m per day. Moose in the northernmost study area with the deepest snow covers moved as much as the moose in the other areas with less snow. Although we saw differences in the movement rates between males and females, differences between individuals were markedly higher than those caused by sex or a calf at heel. Moose are keystone species whose heavy browsing, especially during winter, can have profound effects on vegetation and forest regeneration. As snow covers in large parts of the boreal zone are predicted to decrease due to warming climate, the wintertime movements of moose and how they affect the local vegetation will remain relevant questions.
Nonlinear modeling of the ten-story RC building at E-Defense (2015): assessment with different modeling assumptions
Authors: Di Domenico Mariano , Gaetani d’Aragona Marco , Polese Maria , Magliulo Gennaro , Prota Andrea , Verderame Gerardo M. , Kajiwara Koichi 
Published: February 2023

AbstractTwo models of the 10-story reinforced concrete building tested at E-Defense laboratory in 2015 are built: the F model, in which nonlinear behavior is distributed over the element length, and the H model, in which nonlinear behavior is lumped in plastic hinges with a moment-chord rotation response assigned based on empirical formulations proposed in the literature. Nonlinear time–history analyses are performed to reproduce the experimental shaking-table tests performed at increasing seismic intensity level. The incremental experimental test has been performed twice: the first time (BS test), the structure base was free to slip on a concrete base fixed to the shaking table. After the BS test, a second test was performed on the same structure with the foundation fixed to the concrete base (BF test). Both tests are simulated for both models. When simulating both the BS and BF tests, the seismic input adopted for the numerical analyses is the displacement time-history registered at the base of the specimen’s columns, in order to implicitly account for base slip through the input signal without explicitly modeling the slipping devices. It is observed that the significant damage experienced by the specimen during the runs of BF tests at medium–high seismic intensity is probably triggered by softening and damage of beam-column joints: this is reproduced also by H numerical model and highlights the influence of beam-column joints on the overall seismic response of the structure. In general, it is observed that both numerical models, which were constructed, based on experimental data, only by adopting available and well-established tools proposed in the literature, can reproduce the overall response of the case-study structure, especially in terms of maximum top displacement demand and maximum damage state for structural members, provided that beam-column joints’ contribution is adequately considered.
Validation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk
Authors: Allman Richard , Mu Yi , Dite Gillian S. , Spaeth Erika , Hopper John L. , Rosner Bernard A. 
Published: February 2023

Abstract
Purpose
We compared a simple breast cancer risk prediction model, BRISK (which includes mammographic density, polygenic risk and clinical factors), against a similar model with more risk factors (simplified Rosner) and against two commonly used clinical models (Gail and IBIS).

Methods
Using nested case–control data from the Nurses’ Health Study, we compared the models’ association, discrimination and calibration. Classification performance was compared between Gail and BRISK for 5-year risks and between IBIS and BRISK for remaining lifetime risk.

Results
The odds ratio per standard deviation was 1.43 (95% CI 1.32, 1.55) for BRISK 5-year risk, 1.07 (95% CI 0.99, 1.14) for Gail 5-year risk, 1.72 (95% CI 1.59, 1.87) for simplified Rosner 10-year risk, 1.51 (95% CI 1.41, 1.62) for BRISK remaining lifetime risk and 1.26 (95% CI 1.16, 1.36) for IBIS remaining lifetime risk. The area under the receiver operating characteristic curve (AUC) was improved for BRISK over Gail for 5-year risk (AUC = 0.636 versus 0.511, P < 0.0001) and for BRISK over IBIS for remaining lifetime risk (AUC = 0.647 versus 0.571, P < 0.0001). BRISK was well calibrated for the estimation of both 5-year risk (expected/observed [E/O] = 1.03; 95% CI 0.73, 1.46) and remaining lifetime risk (E/O = 1.01; 95% CI 0.86, 1.17). The Gail 5-year risk (E/O = 0.85; 95% CI 0.58, 1.24) and IBIS remaining lifetime risk (E/O = 0.73; 95% CI 0.60, 0.87) were not well calibrated, with both under-estimating risk. BRISK improves classification of risk compared to Gail 5-year risk (NRI = 0.31; standard error [SE] = 0.031) and IBIS remaining lifetime risk (NRI = 0.287; SE = 0.035).

Conclusion
BRISK performs better than two commonly used clinical risk models and no worse compared to a similar model with more risk factors.