bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Low Systemic Immune-inflammation Index predicts Poor Outcome and Early Recurrence in High-risk Patients with Pancreatic Head Cancer Undergoing Pancreaticoduodenectomy
Authors: Chen Qing , Ren Siqian , Cui Songping , He Qiang , Lang Ren 
Published: January 2023

Abstract
Background: To investigate the clinical significance of preoperative inflammatory status in patients with pancreatic head carcinoma (PHC), we performed a single-center study to assess it.
Method: We studied a total of 164 patients with PHC undergoing PD surgery (with or without allogeneic venous replacement) from January 2018 to April 2022. Systemic immune-inflammation index (SII) was the most important peripheral immune index in predicting the prognosis according to XGBoost analysis. The optimal cutoff value of SII for OS was calculated according toYouden index based on the receiver operating characteristic (ROC) curve and the cohort was divided into Low SII group and High SII group. Demographic, clinical data, laboratory data, follow-up data variables were obtained and compared between the two groups. Kaplan-Meier curves, univariable and multivariable Cox regression models were used to determine the association between preoperative inflammation index, nutritional index and TNM staging system with OS and DFS respectively.
Results: The median follow-up time was 16 months (IQR 23), and 41.4% of recurrences occurred within 1 year. The cutoff value of SII was 563, with a sensitivity of 70.3%, and a specificity of 60.7%. Peripheral immune status was different between the two groups. Patients in High SII group had higher PAR, NLR than those in Low SII group (P＜0.01,＜0.01, respectively), and lower PNI (P＜0.01). Kaplan–Meier analysis showed significantly poorer OS and DFS (P < 0.001, <0.001, respectively) in patients with high SII. By using the multivariable Cox regression model, high SII (HR, 2.056; 95% CI, 1.082–3.905, P=0.028) was significant predictor of OS. Of these 68 high-risk patients who recurrence within one year, patients with widespread metastasis had lower SII and worse prognosis (P＜0.01).
Conclusion: High SII was significantly associated with poor prognosis in patients with PHC. However, in patients who recurrence within one year, SII was lower in patients at TNM stage III. Thus, care needs to be taken to differentiate those high-risk patients.
Do findings on immediate post-radiation advanced MRI change treatment decision and clinical outcome in glioblastoma? A propensity score-matched study
Authors: Moon Hye Hyeon , Kim Ho Sung , Park Ji Eun , Kim Young-Hoon , Kim Jeong Hoon , Lee Ji Sung 
Published: January 2023

Abstract
Purpose
We aim to evaluate efficacy of immediate post-concurrent chemoradiotherapy (CCRT) advanced MRI in patients with glioblastoma to guide treatment decisions and improve survival outcomes.
Methods
This retrospective study included 168 patients with IDH wild-type glioblastoma who showed measurable enlarging enhancing lesion on MRI within 12 weeks after CCRT between January 2013 and August 2021. Patients were classified with positive MRI group when early progression was suspected on advanced MRI. The rate of switching to second-line treatment was compared between patients with positive and negative findings. Overall survival (OS) after adjustment with propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) was compared between patients continuing primary treatment and those switched to second-line treatment. Multivariable Cox proportional hazards analysis was performed on PSM patients.
Results
Among 168 patients, 110 exhibited positive findings and 58 showed negative findings on advanced MRI. The positive MRI group showed higher rate of switching to second-line treatment than negative MRI group (49% [54/110] vs. 2% [1/58]; p < .001). However, OS was not significantly different between two groups after adjustment using PSM (HR, 1.09; CI, 0.72–1.67; p = .68) and IPTW (HR, 1.08; CI, 0.68–1.71; p = .74). Switching to second-line treatment did not show survival benefit in multivariable analysis (HR, 1.20; CI, 0.75–1.92; p = .45).
Conclusion
Although advanced MRI in patients with IDH wild-type glioblastoma influenced clinicians to make early change in treatment, no survival benefit was observed between patients with and without change in treatment.
Updating and refining of economic evaluation of rotavirus vaccination in Spain: A cost-utility analysis
Authors: Imaz-Iglesia Iñaki , Carmona Montserrat , García-Carpintero Esther E. , Martínez-Portillo Alejandro , Alcalde-Cabero Enrique , Linertová Renata , García-Pérez Lidia 
Published: January 2023

Abstract
Background
Two vaccines against rotavirus diseases, Rotarix® and RotaTeq®, are being marketed in Spain; but rotavirus is not among diseases covered by universal vaccination in Spain. The aim was to assess the efficiency of extending Spain’s current targeted rotavirus vaccination strategy including only preterm babies, to a policy of universal vaccination.
Methods
A de novo cohort-based Markov model was built to evaluate the efficiency of three rotavirus vaccination strategies in Spain, i.e., targeted, universal, and no vaccination. Using Rotarix® or RotaTeq®, we compared the cost-utility of these strategies from both a societal and Spanish National Health System (SNHS) perspective. The model represents the most important clinical events conceivably linked to rotavirus infection. Efficacy, effectiveness, safety, costs and utilities were identified by systematic reviews.
Results
Incremental cost-utility threshold (ICUR) is €23,638/QALY (Quality Adjusted Life Year) for targeted vaccination with Rotarix®. The ICUR for the rest of the strategies evaluated are above €30,000/QALY. Sensitivity analysis shows the price as the only parameter that could make the universal vaccination strategy efficient.
Conclusions
Considering a threshold of €25,000/QALY, only targeted vaccination with Rotarix® from the societal perspective would be efficient. Price drops of 36.9% for Rotarix® and 44.6% for RotaTeq® would make universal vaccination efficient.
Preventive treatment modifies endothelial function and oxidative stress status in patients with migraine: an observational study
Authors: Mingot Cristina González , Lasaosa Sonia Santos , Campàs Laura Colàs , Canaval Laura Chilangua , Sánchez Anna Gil , Ruiz Luis Brieva , Alonso María Cristina Marzo , Moncusí Silvia Peralta , Marsal Joan Valls , Carner Serafí Cambray , García Francisco Purroy 
Published: January 2023

Abstract
Background
To evaluate whether preventive treatment can modify endothelial function and the oxidative stress profile of patients with migraines.
Methods
88 treatment-naïve patients with migraines and 56 healthy sex/age matched controls underwent ultrasonography exams and blood tests at baseline, and again in the migraine patients after 3 months’ treatment with metoprolol or topiramate. Biomarkers for endothelial function and oxidative stress were analyzed.
Results
At baseline, patients with migraines had higher C-reactive protein (CRP; 2.55 vs. 1.64 mg/dL; p = 0.025) and lower high-density lipoprotein (HDL) cholesterol (61.7 vs. 66.8 mg/dL; p = 0.048), nitrate (19.4 vs. 27.3 µM; p = 0.037), and isoprostane levels (181 vs. 238 µM; p = 0.036) than matched controls. After treatment biomarker levels improved in patients with migraine, including CRP (2.55 mg/dL at baseline vs. 1.75 mg/dL at 3 months; p = 0.045); HDL cholesterol levels were the exception (significantly decreased). Treatment responders (> 50% reduction from baseline in migraine frequency) had higher nitrate (24.2 vs. 13.8 µM; p = 0.022) and nitrite levels (10.4 vs. 3.4 µM; p = 0.002) than non-responders after treatment.
Conclusion
Patients with migraines exhibit endothelial and oxidative dysfunction, which can be modified with prophylactic therapy.
Prognosis and clinical issues of esophageal atresia in extremely low birth weight neonates: a case series
Authors: Horiike Masaki , Mimura Hitomi , Yokoi Akiko 
Published: January 2023

Abstract
Purpose Esophageal atresia (EA) in extremely low birth weight (ELBW) neonates is rare. This report aimsto clarify the clinical courses and prognosis of EA in ELBW neonates and the clinical issues of long-term survival cases.
Methods A retrospective analysis was conducted for 8 neonates diagnosed with esophageal atresia. Medical records of ELBW EA neonatestreated at our institution were reviewed to assess patient demographics, clinical courses,and outcomes. Transferred patient data was obtained from their local physicians through questionnaires.
Results EA in ELBW neonates were included in 8 of EA infants (7%). Complications of trisomy 18and pulmonary hypoplasia were associated with poor prognosis. During primary operations, gastrostomy and esophageal banding were performed together in 50% of the cases, while gastrostomy was performed alone in 25%. Esophageal anastomosis was not performed during any primary operation. All causes of death, except for 1 case, were due to non-surgical causes. A long-term survival case of 17 years postoperatively was included.
Conclusion Most cases had a high mortality rate. Therefore, it is essential to share information about the prognosis with parents and multidisciplinary specialists and to select an appropriate treatment strategy for each case.
The Economic Effects of COVID-19 Pandemic on the Market Vendors in Kampala City in Uganda
Authors: Kizza James , Kamaduuka Regis Zombeire , Arineitwe Julius , Amwonya David , Kigosa Nathan 
Published: January 2023

Abstract
Background

Ever since the COVID-19 pandemic struck Uganda, much emphasis by the policy makers and researchers were on the health effects of the pandemic at the expense of the economic effects hence creating a research gap. The cardinal aim of this study was therefore to examine the economic effects of the pandemic on the wellbeing of the market vendors in Kampala city, which was the epicenter of the COVID-19 pandemic. The specific objectives of this study were; examining how the COVID-19 pandemic economically affected the market vendors in Kampala city, and determining if the pandemic was a demand or supply side shock.

Methods

the study employed the Blinder-Oaxaca (B-O) decomposition technique, which was originally used in labor economics to decompose earnings gaps and to estimate the level of discrimination. This decomposition method analyses changes in a given variable over time. Descriptive statistics such as means, frequencies, and percentages were generated to gain insights into the data. Consumption and Sales were used as proxies for demand whereas the proxy for supply was production.

Results

The decomposition results from the Oaxaca estimates show that consumption, sales, and production reduced after the introduction of the COVID-19 restriction. The pandemic affected the market vendors economically through reduced consumption, sales, and disruption of the supply chain. It is recommended that the government provide appropriate support in form of income support, access to low credit and building the digital capacity of market vendors.
Research contribution: This study contributes to the understanding of the economic effects of the pandemic on one of the most vulnerable groups-the market vendors.
JEL Codes: 1,118,131
Point Spread Functions of aberrated Leaky annular apertures with defocus
Authors: Sabitha N. , Rani S. Vidya , Venkanna M. , Sagar D. Karuna 
Published: January 2023

Abstract
The point spread function of the optical system in the presence of defocus and primary spherical aberration with the complex Hanning filter with amplitude and phase has been investigated. A substantial improvement in the intensity profile of the impulse response of the optical system has been achieved. When the optical system is subjected to higher orders of aberration and apodization, the optical system behaves like a super-resolver with lateral resolution of the central peak being improved radically. The presence of first minima with zero intensity suits the optical system to be applied for two-point resolution studies in terms of Rayleigh criterion.
Tricomplex Numbers and idempotent elements in C3
Authors: WAGH MAMTA AMOL 
Published: January 2023

Abstract
This paper gives seven different representations or different forms of writings of a tricomplex number which is a generalization of bicomplex numbers. The different writings show different features of this number and help us to understand the structure of tricomplex space, C3. Algebraic structure of C3 has been given. We have shown how C3 is isometric and isomorphic to C22 , C14and C08. We have found that there exist exactly ten nontrivial idempotent elements in C3.
AMS Subject Classification: Primary 32-01, Secondary 32A10, 32A65
MsFaaS: Microservices Forensics as a Service
Authors: Shehata Abubakr , Aslan Heba 
Published: January 2023

Abstract
The rapid increase in using cloud services leads to the rise of unlimited cyber threats. Due to the distributed architect nature, services like Software as a Service (SaaS) are hard to be monitored. Consequently, in digital crimes, the investigator faces several forensics challenges. Mainly, in collecting data and presenting acceptable electronic evidence at the court. While most researchers went towards the external investigator’s responsibility, fewer researchers went to the Cloud Service Provider’s (CSP) responsibility. In literature, no complete framework that resolves all challenges and succeeds in presenting trusted evidence to the court has been suggested. In the present paper, we propose a framework named Microservices Forensics as a Service (MsFaaS) that suggests solutions to resolve open challenges. Since the CSP holds the crime scene and there is a global legal responsibility against digital crimes, MsFaaS relies on enforcing international law and putting the responsibility on both CSP and local authorities where the victim/attacker and CSP operate. We collect several data types and use event reconstruction methodology to build a comprehensive crime scene in both live and postmortem scenarios. In addition, MsFaaS provides a validation service against man-in-the-middle attacks microservices. It also triggers a response action to virtual machines incidents and external attacks; finally, the framework is helpful for auditing and recording the external and internal traffic inside the cloud environment. As a result, the service provided by the framework offers an evidence report that is certified by the local authority which can be accepted in a digital crime trial.
Development of Electrolyte and Nonelectrolyte E-Modules Integrated Demonstration Video and Science Literacy
Authors: Aulia Annisa , Hardeli Hardeli 
Published: January 2023

The type of research used is Educational Design Research with the Plomp development model. The Plomp development model consists of 3 stages, namely; the preliminary research, the prototype phase, and the assessment phase. The research instruments used are; student observation sheets, teacher interview sheets, validity questionnaire sheets, practicality questionnaire sheets, and student learning outcomes tests. The e-module was validated by 5 validators. The results of the e-module validity test were analyzed using the Aiken's V formula, while the practicality test results were analyzed using a Likert scale. The results of the validity of the e-module obtained an average Aiken's V of 0.85 with a valid category and has a CVR value of 1 with a valid category. The results of the practicality of the e-module by teachers and students obtained an average practicality value of 98% and 84% with a very practical practicality category. The results of the e-module effectiveness test obtained an average N-Gain value for the experimental class of 0.63 with a medium category. Based on the research results, it can be concluded that the problem-based learning e-module electrolyte and nonelectrolyte solution integrated demonstration video and scientific literacy that has been developed is valid, practical, and effective.
Evaluation of the Effectiveness of Dantrolene Sodium against Digoxininduced
Cardiotoxicity in Adult Rats
Authors: Zardast Mahmoud , Behmanesh Kosar , Farkhondeh Tahereh , Roshanravan Babak , Aramjoo Hamed , Aschner Michael , Samarghandian Saeed , Kiani Zahra 
Published: January 2023

Background:
Digoxin poisoning commonly occurs in people treated with digoxin. It
has been suggested that treatment with dantrolene may be a suitable strategy for digoxin-induced
cardiotoxicity.

Objective:
The aim of this study was to evaluate the protective effect of dantrolene on digoxininduced
cardiotoxicity in male rats.

Methods:
This study was approved by the ethics committee of Birjand University of Medical
Sciences (Ethical number: IR.BUMS.REC.1400.067). Forty-two Wistar rats weighing between
300- 350 gr were randomly allocated to 7 groups (n = 6) as follows: Normal Saline (NS) group,
Normal Saline + Ethanol (NS + ETOH) group), Normal Saline + dantrolene 10 mg/kg (NS + Dan
10) group, Digoxin (Dig) group), Digoxin + dantrolene 5 mg/kg (Dig + Dan 5) group), Digoxin +
dantrolene 10 mg/kg (Dig + Dan 10) group), Digoxin + dantrolene 20 mg/kg (Dig + Dan 20)
group), Dig was injected intravenously at 12 mL / h (0.25 mg / mL). Dan (5, 10 and 20 mg/kg)
was injected intravenously at 5-8 min/mL. After 1 hour, blood samples were obtained from
the animals' cavernous sinus and each animal's heartremoved. The blood sample was rapidly
centrifuged at 2,500 rpm for 10 minutes and the serum was separated for measurement of creatine
phosphokinase (CPK), potassium (K), sodium (Na), calcium (Ca), and magnesium (Mg). The
samples were stored at -20oC. The heart samples were fixed in formalin 10% for histopathological
evaluation.

Results:
K levels slightly increased in the dig group versus the NS group. A significant increase in
the K levels was observed in the Dig + Dan 20 group versus the NS group (p < 0.001). Dig slightly
decreased Ca levels in the treated group versus the NS group. The levels of Ca significantly increased
in the Dig + Dan 10 group versus the Dig group (p < 0.05). Histological examination of
the heart tissue in the dig group showed cardiomyocyte degeneration, increased edematous intramuscular
space associated with hemorrhage, and congestion. Focal inflammatory cell accumulation
in the heart tissue was also seen. Cardiomyocytes were clear and arranged in good order in the
Dig + Dan 10 group.

Conclusion:
dantrolene (10 mg/kg) was cardioprotective in a model of digoxin-induced cardiotoxicity,
secondary to cardiac remodeling and hyperkalemia. However, further research is necessary
to determine dantrolene's cardioprotective and cardiotoxic doses in animal models.
Cardio Protective Approach of Unani Dietotherapy with Special
Reference to Avicenna’s Risaala Adwiyah Al Qalbiyah
Authors: Nabi Afshana , Itrat Malik , Khan Tariq Nadeem 
Published: January 2023

Background and Objective:
The present paper will enlighten the role of different types
of diets in maintaining a healthy heart, as mentioned by Ibn Sina in his valuable work “Risaala
adwiyah al Qalbiyah”. Owing to an increased trend of dietotherapy in the current era, this paper is
an attempt to enhance the same (particularly the cardio-protective diets).

Methodology:
Risaala adwiyah al Qalbiyah is an important work of Ibn Sina focusing on the
maintenance of heart health. For the current study, we have selected a total of thirteen nutraceuticals
out of sixty-three that can be taken in the routine diet to avail of their benefits and avoid the risk of
cardiovascular diseases, which are at their peak at present. To meet this need, a thorough literature
survey of classical literature was conducted to collect all the necessary and relevant information.
These medicines/diets were looked upon for their proven benefits by searching them with their botanical
names using modern search engines like PubMed, Google Scholar and Research Gate to
provide an evidence-based edge to the current work.

Results:
The specific diets mentioned by Ibn Sina have proved to possess potential effects in preventing
cardiovascular diseases and thus promoting cardiac health.

Conclusion:
Dietotherapy plays a primary role in achieving the principal goal of the Unani system
of medicine (the preservation of health and prevention of diseases). Food items mentioned in this
paper can be added to the routine to get the benefits from their cardio-protective action and avoid
the risk of highly increasing cardiovascular diseases.
Implementación del espectro de curvas de diseño ramcodes de suelos no saturados de subrasantes en el diseño de pavimentos flexibles
Authors: Inga López Hainer Josué , Gutiérrez Lazares José Wilfredo 
Published: January 2023

The design process for a pavement structure assumes that the subgrade will saturate at some point during the service life, however, the saturation of the subgrade depends on the conditions depending on the region in which it is located. Therefore, it is necessary to study design conditions for partially saturated subgrade. The present research aims to implement the spectrum of RAMCODES design curves for unsaturated subgrade soils, applied to the design of flexible pavements under environmental and traffic conditions associated with the Oyon-Ambo highway. To construct the RAMCODES design curves, CBR tests were performed by varying compaction energies and moisture contents. Likewise, using the OriginPro 2019 program, the curves were obtained and a mathematical model was used to predict the variation of the degree of saturation in the subgrade over time. Subsequently, the seasonal CBR were obtained and correlated to obtain the resilient moduli. Finally, two flexible pavement structure designs were carried out, one using the traditional subgrade characterization methodology and the other according to the proposed methodology. From the results obtained, it is interpreted that the consideration of the unsaturated behavior of the subgrade optimizes the pavement design since the bearing capacity of the subgrade is increased by 28.8%, which means that the thickness of the subbase layer is reduced by 25%.
Propuesta para obtener las máximas aceleraciones de piso usando la norma sísmica peruana e.030
Authors: Sánchez Meza Roque Alberto 
Published: January 2023

The collapse of some floor diaphragms during earthquakes was due to failures in connection with vertical elements or because those were not designed for seismic forces in its plane. This has made that the design of diaphragms is an issue that has been incorporated in many seismic codes. For its design, it is necessary the maximum acceleration on each floor during a strong seismic event. The seismic Peruvian code E.030 does not include any methodology about how to calculate those accelerations floor, it only refers to acceleration on floors but due to maximum base shear which does not correspond to maximum acceleration in each level.
In this paper, a simplified procedure for obtaining maximum floor accelerations is shown. This procedure is based on First Mode Reduced method [1] to which a factor rW was included to consider higher modes participation in dual systems (frames / walls). The rW factor corresponds to the ratio of base moment in walls and base moment in the building. In the validation of the procedure, it was observed that the proposed procedure agrees with the results of experimental and analytical models.