bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and Pulmonary Protective Potential of Fraxinus xanthoxyloides Bark Extract against CCl4‐Induced Toxicity in Rats
Authors: Younis Tahira , Jabeen Faiza , Hussain Ali , Rasool Bilal , Raza Ishaq Ali , Nawaz Atif , El‐Nashar Heba A. S. , El‐Shazly Mohamed 
Published: February 2023

AbstractFraxinus xanthoxyloides is a perennial shrub belonging to family Oleaceae, traditionally used for malaria, jaundice, pneumonia, inflammation, and rheumatism. Our study is aimed to assess the total phenolics (TPC), flavonoids (TFC), terpenoids contents (TTC) and antioxidant profiling of F. xanthoxyloides methanol bark extract (FXBM) and its fractions, hexane, chloroform, ethyl acetate and aqueous, along with high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). Further, the antioxidant and pulmonary protective potential was explored against carbon tetrachloride (CCl4)‐induced CCl4‐induced pulmonary tissue damage in rats. The highest TPC, TFC and TTC were found in FXBM (133.29±4.19 mg/g), ethyl acetate fraction (279.55±10.35 mg/g), and chloroform fraction (0.79±0.06 mg/g), respectively. The most potent antioxidant capacity was depicted by FXBM (29.21±2.40 μg/mg) and ethyl acetate fraction (91.16±5.51 μg/mg). The HPLC‐DAD analysis revealed the predominance of gallic, chlorogenic, vanillic and ferulic acid in FXBM. The administration of CCl4 induced oxidative stress, suppressed antioxidant enzymes′ activities including catalase, peroxidase, superoxide dismutase, glutathione peroxidase, glutathione‐S‐transferase, and glutathione reductase. Further, it increased thiobarbituric acid reactive substances (TBARS) and H2O2 levels, induced DNA injuries and reduced the total protein and glutathione content in lung tissues. The treatment of rats with FXBM restored these biochemical parameters to the normal level. Moreover, the histopathological studies of lung tissues demonstrated that FXBM protected rats′ lung tissues from oxidative damage restoring normal lung functions. Thus, F. xanthoxyloides bark extract is recommended as adjuvant therapy as protective agent for patients with lung disorders.
Ventricular arrhythmias following balloon‐expandable transcatheter pulmonary valve replacement in the native right ventricular outflow tract
Authors: Barfuss Spencer B. , Samayoa Juan Carlos , Etheridge Susan P. , Pilcher Thomas A. , Asaki Sarah Yukiko , Ou Zhining , Boucek Dana M. , Martin Mary Hunt , Gray Robert G. , Niu Mary C. 
Published: January 2023

AbstractBackgroundVentricular arrhythmia incidence in children and adolescents undergoing transcatheter pulmonary valve replacement (TPVR) within the native right ventricular outflow tract (nRVOT) is unknown. We sought to describe the incidence, severity, and duration of ventricular arrhythmias and identify associated risk factors in this population.MethodsThis was a retrospective cohort study of 78 patients <21 years of age who underwent TPVR within the nRVOT. Patients were excluded for pre‐existing ventricular arrhythmia or antiarrhythmic use. Study variables included surgical history, valve replacement indication, valve type/size, and ventricular arrhythmia. Univariable logistic regression models were used to evaluate factors associated with ventricular arrhythmias, followed by subset analyses.ResultsNonsustained ventricular arrhythmia occurred in 26/78 patients (33.3%). The median age at the procedure was 10.3 years (interquartle range [IQR]: 6.5, 12.8). Compared with other nRVOT types, surgical repair with transannular patch was protective against ventricular arrhythmia incidence: odds ratio (OR): 0.35 (95% confidence interval [CI], 0.13–0.95). Patient weight, valve type/size, number of prestents, and degree of stent extension into the RVOT were not associated with ventricular arrhythmia occurrence. Beta blocker was started in 16/26 (61.5%) patients with ventricular arrhythmia. One additional patient was lost to follow‐up. The median beta blocker duration was 46 days (IQR 42, 102). Beta blocker was discontinued in 10 patients by 8‐week follow‐up and in the remaining four by 9 months.ConclusionsThough common after balloon‐expandable TPVR within the nRVOT, ventricular arrhythmias were benign and transient. Antiarrhythmic medications were successfully discontinued in the majority at 6‐ to 8‐week follow‐up, and in all patients by 20 months.
Impact of technique on bifurcation stent outcomes in the European Bifurcation Club Left Main Coronary Trial
Authors: Arunothayaraj Sandeep , Lassen Jens Flensted , Clesham Gerald J. , Spence Mark S. , Koning René , Banning Adrian P. , Lindsay Mitchell , Christiansen Evald H. , Egred Mohaned , Cockburn James , Mylotte Darren , Brunel Philippe , Ferenc Miroslaw , Hovasse Thomas , Wlodarczak Adrian , Pan Manuel , Silvestri Marc , Erglis Andrejs , Kretov Evgeny , Chieffo Alaide , Lefèvre Thierry , Burzotta Francesco , Darremont Olivier , Stankovic Goran , Morice Marie‐Claude , Louvard Yves , Hildick‐Smith David 
Published: January 2023

AbstractBackgroundTechniques for provisional and dual‐stent left main bifurcation stenting require optimization.AimTo identify technical variables influencing procedural outcomes and periprocedural myocardial infarction following left main bifurcation intervention.MethodsProcedural and outcome data were analyzed in 438 patients from the per‐protocol cohort of the European Bifurcation Club Left Main Trial (EBC MAIN). These patients were randomized to the provisional strategy or a compatible dual‐stent extension (T, T‐and‐protrude, or culotte).ResultsMean age was 71 years and 37.4% presented with an acute coronary syndrome. Transient reduction of side vessel thrombolysis in myocardial infarction flow occurred after initial stent placement in 5% of procedures but was not associated with periprocedural myocardial infarction. Failure to rewire a jailed vessel during any strategy was more common when jailed wires were not used (9.5% vs. 2.5%, odds ratio [OR]: 6.4, p = 0.002). In the provisional cohort, the use of the proximal optimization technique was associated with less subsequent side vessel intervention (23.3% vs. 41.9%, OR: 0.4, p = 0.048). Side vessel stenting was predominantly required for dissection, which occurred more often following side vessel preparation (15.3% vs. 4.4%, OR: 3.1, p = 0.040). Exclusive use of noncompliant balloons for kissing balloon inflation was associated with reduced need for side vessel intervention in provisional cases (20.5% vs. 38.5%, OR: 0.4, p = 0.013), and a reduced risk of periprocedural myocardial infarction across all strategies (2.9% vs. 7.7%, OR: 0.2, p = 0.020).ConclusionWhen performing provisional or compatible dual‐stent left main bifurcation intervention, jailed wire use is associated with successful jailed vessel rewiring. Side vessel preparation in provisional patients is linked to increased side vessel dissection requiring stenting. Use of the proximal optimization technique may reduce the need for additional side vessel intervention, and noncompliant balloon use for kissing balloon inflation is associated with a reduction in both side vessel stenting and periprocedural myocardial infarction.Clinical Trial RegistrationClinicalTrials.gov Identifier NCT02497014.
Iliofemoral artery predilation prior to transfemoral transcatheter aortic valve implantation in patients with aortic valve stenosis and advanced peripheral artery disease
Authors: Alvarez‐Covarrubias Hector A. , Joner Michael , Cassese Salvatore , Warmbrunn Mairead , Lutz Jannik , Trenkwalder Teresa , Seguchi Masaru , Aytekin Alp , Presch Antonia , Pellegrini Constanza , Rheude Tobias , Patrick Mayr N. , Kufner Sebastian , Schunkert Heribert , Kastrati Adnan , Xhepa Erion 
Published: January 2023

AbstractObjectivesTo investigate the feasibility and safety of percutaneous transluminal angioplasty (PTA) of the iliofemoral arteries (IFA) before transfemoral transcatheter aortic valve implantation (Tf‐TAVI) in patients with advanced peripheral artery disease (PAD).BackgroundAlthough Tf‐TAVI represents the access of choice, alternative vascular access routes are preferred for patients displaying advanced PAD. PTA of the IFA represents a less invasive option, broadening the spectrum of patients eligible for Tf‐TAVI.MethodsAll patients requiring PTA of the IFA before Tf‐TAVI, between 2012 and 2021, were included. Primary efficacy endpoint was the rate of successful transcatheter heart valve (THV) delivery and implantation. Primary safety endpoint was the rate of PTA and access‐site‐related vascular complications, procedural‐ and in‐hospital complications.ResultsAmong 2726 Tf‐TAVI procedures, 59 patients required IFA predilation. Successful THV delivery and implantation was achieved in 57 (96.6%) patients, respectively. Sheath placement was achieved in 59 (100%) patients with only one minor dissection and no major vascular complications following iliofemoral PTA. Regarding access site complications, two (3.4%) vessel perforations and one (1.7%) vessel rupture were observed, with eight (13.5%) patients requiring unplanned endovascular interventions. There was one intraprocedural death due to THV‐induced vessel laceration, while in‐hospital all‐cause mortality was 8.5% in the present high‐risk patient cohort.ConclusionsPredilation of IFA is safe and effective in patients with advanced PAD. Careful preprocedural planning is paramount in improving procedural safety and efficacy. This strategy has the potential to broaden the spectrum of patients eligible for Tf‐TAVI.
Suitability of Sodium Pyruvate as Decomposer of Carried‐over Liquid Hydrogen Peroxide
Authors: Belschner Diana , Rosenberger Melanie , Atamer Zeynep , Hinrichs Jörg , Kosian Thomas , Rauschnabel Johannes 
Published: February 2023

AbstractThe aim of the present study was to evaluate the concentration of sodium pyruvate in growth media by using the most‐probable number method to decompose carried‐over liquid hydrogen peroxide (H2O2) without negative influences on correct enumeration of Geobacillus stearothermophilus spores. An equivalent molar ratio of sodium pyruvate and H2O2 was verified to be sufficient for a complete decomposition. The results showed that by exposition of G. stearothermophilus spores in different liquid hydrogen peroxide and by carry‐over of concentrations ranging from 3.56 · 10−6 up to 1.69 · 10−4 mol, a sodium pyruvate concentration of 0.05 mol L−1 in growth media was most efficient for the recovery of spores.
A comprehensive test of colour‐difference formulae and uniform colour spaces using available visual datasets
Authors: Luo Ming Ronnier , Xu Qiang , Pointer Michael , Melgosa Manuel , Cui Guihua , Li Changjun , Xiao Kaida , Huang Min 
Published: February 2023

AbstractThe paper describes a comprehensive test to evaluate the performance of current colour‐difference models using available experimental datasets. In total, 28 individual datasets were accumulated to test 17 colour‐difference formulae, 13 of them based on Uniform Colour Spaces (UCSs) in terms of the Standardized Residual Sum of Squares (STRESS) measure. The 28 datasets were divided into three groups: Large Colour‐Difference data (LCD), Small Colour‐Difference data for surface colours (SCDs), and Small Colour Difference data for display colours (SCDd). For each colour model, four versions were tested: the original model, and that including kL‐, Gamma‐ and kL/Gamma, which are the lightness parametric factor, the colour‐difference exponent factor, and the combination of both, respectively, optimized to fit particular dataset(s). The statistical F‐test was applied to test the difference between each pair of models. Furthermore, parametric effects between the large/small colour‐difference magnitudes, and between surface/display colours were investigated. The results showed that CAM16‐UCS significantly outperformed the other models for all groups. It accurately predicted all types of data and should be proposed for colour‐difference evaluation across all industries.
Employing factor analytic tools for selecting high‐performance and stable tropical maize hybrids
Authors: Chaves Saulo F. S. , Evangelista Jeniffer S. P. C. , Trindade Roberto S. , Dias Luiz A. S. , Guimarães Paulo E. , Guimarães Lauro J. M. , Alves Rodrigo S. , Bhering Leonardo L. , Dias Kaio O. G. 
Published: January 2023

AbstractGenotype‐by‐environment interaction (GEI) is a major concern in tropical maize breeding. Here, we used factor analytic mixed models (FAMM) to study GEI in a tropical maize dataset. Our goal was to select high‐performance and stable hybrids using factor analytic selection tools (FAST) derived from FAMM outputs. Because the dataset comprised two different planting seasons, we also investigated differences in the genetic gains between seasonal and general selection (i.e., for both seasons simultaneously). The trials were installed in a lattice design with 36 hybrids containing two replicates and blocks with six plants each. We evaluated 53 hybrids and seven checks in 48 environments, represented by a combination of locations, years and seasons. We fitted the FAMMs with distinct sets of factors. The best‐fitted FAMM was selected considering a parsimony‐explained variance balance. Using the best FAMM for both seasonal and general analyses, we estimated the following selection tools: overall performance (); root mean square deviation (), which represents general stability; and responsiveness , which represents specific stability. We selected hybrids based on an index built with and . Five and three hybrids were selected considering both general and seasonal analyses for the first and second season, respectively. Two hybrids were amongst the top eight for both seasonal analyses (i.e., only first season and only second season simultaenously). Higher genetic gains may be obtained by employing FAMM and using FAST in each season rather than analysing both seasons in a joint fashion.
Are biologically synthesized electrolytes the future in green energy storage?
Authors: Wilhelmsen Charlotte Overgaard , Muff Jens , Sørensen Jens Laurids 
Published: February 2023

AbstractThe production of renewable energy from solar panels and windmills is rapidly increasing these years. However, one of the biggest hurdles that need to be overcome in the green transition is cost‐efficient energy storage to reach the full exploitation of their potential. A promising energy storage technology is redox flow batteries (RFBs), particularly using quinones as electron carriers. The prototypes of quinone batteries have been derived from crude oil, which unfortunately falls short of the ambition of sustainable energy production purely from renewable sources. It is well‐known that filamentous fungi have a great capacity for quinone production. and the first RFB with a fungal‐produced quinone was recently generated as a proof‐of‐concept. Here, we give our opinion and perspectives on which challenges need to be solved before an RFB with fungal‐produced quinones can be applied in the green transition.
Electrochemical impedance spectroscopy studies of the buffered and non‐buffered microbial fuel cell
Authors: Nourbakhsh Fatemeh , Mohsennia Mohsen , Pazouki Mohammad 
Published: January 2023

AbstractThe positive effect of buffers to maintain a sui pH for microorganism growth and increase the electrolyte conductivity in microbial fuel cells (MFCs) encourages more studies on the development of new buffer solutions. The effect of types of biological buffers such as phosphate, tris, succinate, and maleate on power production in dual chamber MFC inoculated by saccharomyces cerevisiae has been examined. Electrochemical impedance spectroscopy has been used for evaluating the performance of the buffered and non‐buffered MFC systems. Considering the important impact of buffer type on the resistance of ion migration within the electrolyte and electron transport resistance of the cell components, the internal resistance of the MFC with different used buffers has been obtained and compared. According to the obtained results, the tris buffer solution showed a positive influence on the power output with a power density of 25.41% higher than phosphate.
Minimum hydrogen consumption‐based energy management strategy for hybrid fuel cell unmanned aerial vehicles using direction prediction optimal foraging algorithm
Authors: Quan Rui , Li Zhongxin , Liu Pin , Li Yangxin , Chang Yufang , Yan Huaicheng 
Published: January 2023

AbstractIn hybrid energy storage systems of fuel cell unmanned aerial vehicles (UAVs), achieving energy management while minimizing hydrogen consumption is the main goal for economic aspects and endurance enhancement. The external energy maximization strategy (EEMS) and the equivalent consumption minimization strategy (ECMS) are commonly used energy management strategies. However, they use a gradient descent approach, which converges slowly and does not guarantee the optimal solution. Thus, this paper proposes an optimization method based on a direction prediction optimal foraging algorithm (OFA/DP), which has the advantages of high optimization capability and simple parameter definition. In this study, the hybrid energy storage system comprises fuel cells and lithium‐ion batteries for powering UAVs. To verify the validity of the proposed strategy, it is compared with rule‐based and optimized methods of state machine control, fuzzy logic control based on frequency separation, ECMS, EEMS, and genetic algorithm. The obtained results confirm the superiority of the proposed OFA/DP‐based EEMS method with an efficiency of 88.65% and a minimum hydrogen consumption of 19.06 g. Furthermore, it achieves optimal power distribution and leads to 38.62% minimization in hydrogen consumption.
Fish Protein Hydrolysate from Sulfated Polysaccharides Extraction Residue of Tuna Processing By‐Products with Bioactive and Functional Properties
Authors: Naghdi Shahab , Rezaei Masoud , Tabarsa Mehdi , Abdollahi Mehdi 
Published: January 2023

AbstractThe ethanol‐induced precipitation after enzymatic hydrolysis commonly used for sulfated polysaccharide extraction from marine resources wastes a large amount of proteins. Here, possible extraction of fish protein hydrolysates (FPH) from the ethanol residue of sulfated polysaccharide precipitation from head, bone, and skin of skipjack tuna is investigated. Antioxidant, antibacterial, angiotensin I‐converting enzyme (ACE) inhibitory activities and functional properties of the recovered FPHs are also evaluated. A degree of hydrolysis of 40.93, 38.13, and 37.23 is achieved for FPH from head, bone, and skin, respectively. FPH from the head presents the highest antioxidant and ACE inhibitory activity as well as foam/emulsion capacity among all the FPHs. The FPHs are all able to inhibit three Gram‐positive bacteria and three Gram‐negative bacteria to varying degrees and have a water solubility >65%. Altogether, the results demonstrate great potential for recovery of bioactive/functional peptides from the residue of sulfated polysaccharide extraction process enabling efficient biorefining of aquatic resources.
In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis
Authors: Lee Hyunah , Price Jack , Srivastava Deepak P. , Thuret Sandrine 
Published: January 2023

AbstractHippocampal neurogenesis (HN) is considered an important mechanism underlying lifelong brain plasticity, and alterations in this process have been implicated in early Alzheimer's disease progression. APOE polymorphism is the most common genetic risk factor for late‐onset Alzheimer's disease where the ε4 genotype is associated with a significantly earlier disease onset compared to the neutral ε3 allele. Recently, APOE has been shown to play an important role in the regulation of HN. However, the time‐dependent impact of its polymorphism in humans remains elusive, partially due to the difficulties of studying human HN in vivo. To bridge this gap of knowledge, we used an in vitro cellular model of human HN and performed a time course characterization on isogenic induced pluripotent stem cells with different genotypes of APOE. We found that APOE itself was more highly expressed in ε4 at the stem cell stage, while the divergence of differential gene expression phenotype between ε4 and ε3 became prominent at the neuronal stage of differentiation. This divergence was not associated with the differential capacity to generate dentate gyrus granule cell‐like neurons, as its level was comparable between ε4 and ε3. Transcriptomic profiling across different stages of neurogenesis indicated a clear “maturation of functional neurons” phenotype in ε3 neural progenitors and neurons, while genes differentially expressed only in ε4 neurons suggested potential alterations in “metabolism and mitochondrial function.” Taken together, our in vitro investigation suggests that APOE ε4 allele can exert a transcriptome‐wide effect at the later stages of HN, without altering the overall level of neurogenesis per se.
Elimination of perineuronal nets in CA1 disrupts GABA release and long‐term contextual fear memory retention
Authors: Liu Luping , Zhang Yujie , Men Siqi , Li Xuanyi , Hou Sheng‐Tao , Ju Jun 
Published: January 2023

AbstractPerineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate fear‐associated memory, but the molecular mechanism is still unclear. In this study, we found that removal of PNNs in vivo using chondroitinase ABC (ChABC) injection resulted in reduced firing rate of PV neurons and decreased inhibitory synaptic transmission in both PV neurons and excitatory neurons in the CA1 hippocampus. Interestingly, altered synaptic transmission appears to be mediated by presynaptic changes. Furthermore, ChABC treatment disrupts long‐term contextual fear memory retention. These results suggest PNNs might alter fear memory by reducing the presynaptic GABA release.
Computing grain boundary “phase” diagrams
Authors: Luo Jian 
Published: January 2023

AbstractGrain boundaries (GBs) can be treated as two‐dimensional (2‐D) interfacial phases (also called “complexions”) that can undergo interfacial phase‐like transitions. As bulk phase diagrams and calculation of phase diagram (CALPHAD) methods serve as a foundation for modern materials science, we propose to extend them to GBs to have equally significant impacts. This perspective article reviews a series of studies to compute the GB counterparts to bulk phase diagrams. First, a phenomenological interfacial thermodynamic model was developed to construct GB lambda diagrams to forecast high‐temperature GB disordering and related trends in sintering and other properties for both metallic and ceramic materials. In parallel, an Ising‐type lattice statistical thermodynamic model was utilized to construct GB adsorption (segregation) diagrams, which predicted first‐order GB adsorption transitions and critical phenomena. These two simplified thermodynamic models emphasize the GB structural (disordering) and chemical (adsorption) aspects, respectively. Subsequently, hybrid Monte Carlo and molecular dynamics atomistic simulations were used to compute more rigorous and accurate GB “phase” diagrams. Computed GB diagrams of thermodynamic and structural properties were further extended to include mechanical properties. Moreover, machine learning algorithms were combined with atomistic simulations to predict GB properties as functions of four independent compositional variables and temperature in a 5‐D space for a given GB in high‐entropy alloys or as functions of five GB macroscopic (crystallographic) degrees of freedom plus temperature and composition for a binary alloy in a 7‐D space. Other relevant studies are also examined. Future perspective and outlook, including two emerging fields of high‐entropy grain boundaries (HEGBs) and electrically (or electrochemically) induced GB transitions, are discussed.