bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal‐Free Electrochemical Hydroboration of Olefins
Authors: Yuan Qilin , Zhang Xiao , Guo Lin , Yang Chao , Xia Wujiong 
Published: May 2023

AbstractHerein, we reported the electrochemical hydroboration of olefins to access the organoboron derivatives in a one‐pot reaction under air and at room temperature. This reaction manifold was applied to a broad range of alkenes with 40–90% yields and good functional group tolerance without using a metal catalyst or an additional hydride source. Mechanistic studies suggested that this anodic oxidation conducted in an undivided cell allowing the production of a boron radical species, which initiates the hydroboration of olefins event by a radical addition process.
XO2 (X = Pd, Pt) Monolayers: A Promising Thermoelectric Materials
Authors: Wani Aadil Fayaz , Patra Lokanath , Srinivasan Marutheeswaran , Singh Jaspal , Abdelmohsen Shaimaa A. M. , Alanazi Meznah M. , Dhiman Shobhna , Kaur Kulwinder 
Published: May 2023

AbstractIn this work, the structural, thermoelectric, and electronic properties of XO2 (X = Pd, Pt) monolayers are investigated using density functional approach and Boltzmann transport equations (BTE). These materials are semiconductor in nature having indirect band gap 1.40 (1.69 eV) for PdO2 (PtO2) monolayers. These materials are chemically as well as dynamical stable. The observation of a sharp peak in the vicinity of the Fermi level indicates a high value of the Seebeck coefficient (S). The calculated value of S is 2269 (2734) µV K−1 with respect to n (p)‐type doping at carrier concentration of 1.12 (2.33) × 1013 cm−2 for PdO2 (PtO2) monolayer at 300 K. Calculations reveal a lattice thermal conductivity (κl) of 15.85 and 12.41 Wm−1K−1 for PdO2 and PtO2 monolayers, respectively at room temperature. Monolayer PtO2 shows a larger S and smaller k as compared to PdO2. Due to the maximum value of power factor and minimum value of lattice thermal conductivity, ZT for n‐type doped PtO2 monolayer (1.04) is higher than PdO2 monolayers (0.87). The findings provide a blueprint for evaluating the thermal energy conversion efficiency of XO2 monolayers for potential thermoelectric applications.
m6A‐Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis
Authors: Yang Xia , Bai Qiaorui , Chen Weizhong , Liang Jiaer , Wang Fang , Gu Weiqi , Liu Lei , Li Quanfeng , Chen Zishuo , Zhou Anni , Long Jianting , Tian Han , Wu Jueheng , Ding Xiaofan , Zhou Ningning , Li Mengfeng , Yang Yi , Cai Junchao 
Published: May 2023

AbstractThe importance of mRNA N6‐methyladenosine (m6A) modification during tumor metastasis is controversial as it plays distinct roles in different biological contexts. Moreover, how cancer cell plasticity is shaped by m6A modification is interesting but remains uncharacterized. Here, this work shows that m6A reader insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is remarkably upregulated in metastatic lung adenocarcinoma (LUAD) and indicates worse prognosis of patients. Interestingly, IGF2BP3 induces partial epithelial‐mesenchymal‐transition (EMT) and confers LUAD cells plasticity to metastasize through m6A‐dependent overactivation of Notch signaling. Mechanistically, IGF2BP3 recognized m6A‐modified minichromosome maintenance complex component (MCM5) mRNAs to prolong stability of them, subsequently upregulating MCM5 protein, which competitively inhibits SIRT1‐mediated deacetylation of Notch1 intracellular domain (NICD1), stabilizes NICD1 protein and contributes to m6A‐dependent IGF2BP3‐mediated cellular plasticity. Notably, a tight correlation of the IGF2BP3/MCM5/Notch axis is evidenced in clinical LUAD specimens. Therefore, this study elucidates a critical role of m6A modification on LUAD cell plasticity in fostering tumor metastasis via the above axis, providing potential targets for metastatic LUAD.
On‐farm growth performance of different strains of tilapia, Oreochromis niloticus reared in earthen ponds
Authors: Abwao Jacob , Kyule Domitila , Junga Joseph O. , Barasa James E. , Sigana Dorcus A. 
Published: May 2023

AbstractThe growth of aquaculture sector in Kenya has been anchored on farmed Nile tilapia Oreochromis niloticus. Different strains of the species exist in Kenya with unknown quality due to lack of stock improvement programmes coupled by variations in breeding and management practices in different hatcheries. The seeds supplied to farmers have not exhibited good performance and resilience to changing climate. There is need to validate the quality of strains supplied to fish farmers in Kenya. This study sought to compare the growth performance of three strains of farmed Nile tilapia; Sagana strain (SAG‐F8) produced through selective breeding, super YY strain (KAM‐YY) from Kamuthanga fish farm and the local strain (LOC‐T) obtained from Siaya County. The fish were stocked in fertilised earthen ponds measuring 300 m2 in triplicates at 3 fish/m2. The fish were fed on 35% crude protein diet for 180 days at Bukani Aquapark located in Busia County, Kenya. There was no significant difference in mean weight gain (MWG) between SAG‐F8 and LOC‐T strain exhibiting 159.786 ± 6.76 g and 158.623 ± 4.67 g, respectively. However, under similar conditions, the KAM‐YY strain had a significantly lower MWG (131.74 ± 4.75 g) compared to the two strains. Food conversion ratio (FCR), specific growth rate (SGR) did not demonstrate any significant difference among the different strains. The body protein content in the SAG‐F8 fish strain was higher (65.40 ± 0.20%) followed by LOC‐T strain (61.23 ± 2.34%) and lastly KAM‐YY strain had the lowest (60.37 ± 0.89%). In this study, the impact of genetic improvement has been demonstrated to influence growth and feed efficiency as well as body composition. These improved strains will substantially increase fish production and productivity, hence, a positive impact on the fish farmers' livelihoods when supplied to the farmers and seed multipliers.
A call‐to‐action to assist in efforts to protect owl monkeys (Aotus spp.)
Authors: Wolovich Christy K. , Shanee Sam , Maldonado Angela M. , Méndez‐Carvajal Pedro G. , Perea‐Rodriguez Juan P. , Tabares Sebastian , Garcia de la Chica Alba , Evans Siân 
Published: May 2023

AbstractThe majority of the 11 species of owl monkeys (Aotus spp.) have declining populations or are listed as data deficient. Deforestation due to agriculture, development, or logging poses threats to owl monkeys throughout their range. In some areas, Aotus are hunted for bushmeat or trapped for the wildlife trade. In Colombia, the country with the greatest number of Aotus species, owl monkeys are also threatened by civil unrest. To help combat these challenges, nonprofit organizations and field researchers in habitat countries have successfully implemented a variety of conservation projects such as censusing and monitoring owl monkey populations, establishing protected areas, reforesting degraded areas, filing lawsuits to protect wild populations, helping law enforcement with environmental regulation, and promoting environmental education. We highlight some of the conservation successes and suggest actions people around the world can take to contribute to these important efforts.
A Triply [5]Helicene‐Bridged (1,3,5)Cyclophane
Authors: Aribot Frédéric , Merle Amélie , Dechambenoit Pierre , Bock Harald , Artigas Albert , Vanthuyne Nicolas , Carissan Yannick , Hagebaum‐Reignier Denis , Coquerel Yoann , Durola Fabien 
Published: May 2023

AbstractA rigid propeller‐shaped conjugated triple macrocycle consisting of two nearly perfectly stacked benzene rings and three linking [5]helicene moieties has been synthesized using a glyoxylic Perkin approach. Analysis of the electron delocalization in this atypical aromatic molecule revealed global aromaticity and a 78 π‐electron circuit along the edge of its triple loop, to the detriment of the two 6 π‐electron circuits in the two stacked benzene rings.
Copper‐Catalyzed Radical Enantioselective Synthesis of γ‐Butyrolactones with Two Non‐vicinal Carbon Stereocenters
Authors: Xue Mengyu , Cui Jinfeng , Zhu Xiaotao , Wang Fei , Lv Daqi , Nie Zaicheng , Li Yajun , Bao Hongli 
Published: May 2023

AbstractChiral heterocycles with two or more carbon stereocenters are quite important skeletons in many fields. However, powerful strategies for the construction of such synthetically valuable heterocycles, especially with two or more remote carbon stereocenters, have largely lagged behind. We report here a powerful method for the synthesis of chiral γ‐butyrolactones with two non‐vicinal carbon stereocenters from readily available chemical feedstocks under mild conditions. Both of the two diastereoisomers can be obtained with good to excellent enantioselectivities. The well‐designed copper/PyBox catalytic system overrides the intrinsic stereoinduction of the close chirality center generated by the previous innocent radical addition step. Nevertheless, this work has the power to selectively provide one single diastereoisomer by taking advantage of the epimerization effect but also to synthesize all four diastereoisomers with the pair of chiral ligands L2 and L2′ having opposite chirality. The obtained useful chiral γ‐butyrolactones can be synthetically transformed into acyclic or cyclic molecules with two non‐vicinal carbon stereocenters. Mechanistic studies reveal that this radical reaction follows a linear relationship and can be well performed with a less loading amount of ligand compared to that of the copper catalyst.
Thermocatalytic Conversion of CO2 to Valuable Products Activated by Noble‐Metal‐Free Metal‐Organic Frameworks
Authors: Hou Sheng‐Li , Dong Jie , Zhao Xin‐Yuan , Li Xiang‐Shuai , Ren Fang‐Yu , Zhao Jian , Zhao Bin 
Published: May 2023

AbstractThermocatalysis of CO2 into high valuable products is an efficient and green method for mitigating global warming and other environmental problems, of which Noble‐metal‐free metal–organic frameworks (MOFs) are one of the most promising heterogeneous catalysts for CO2 thermocatalysis, and many excellent researches have been published. Hence, this review focuses on the valuable products obtained from various CO2 conversion reactions catalyzed by noble‐metal‐free MOFs, such as cyclic carbonates, oxazolidinones, carboxylic acids, N‐phenylformamide, methanol, ethanol, and methane. We classified these published references according to the types of products, and analyzed the methods for improving the catalytic efficiency of MOFs in CO2 reaction. The advantages of using noble‐metal‐free MOF catalysts for CO2 conversion were also discussed along the text. This review concludes with future perspectives on the challenges to be addressed and potential research directions. We believe that this review will be helpful to readers and attract more scientists to join the topic of CO2 conversion.
A Crowning Achievement: The First Solution‐Phase Synthesis of Circumcoronenes
Authors: Gershoni‐Poranne Renana , Tsybizova Alexandra 
Published: May 2023

AbstractCircumcoronene is a highly symmetric polybenzenoid hydrocarbon that has fascinated organic chemists and materials scientists for decades. However, until recently, it had only been studied theoretically, because its synthesis in solution remained challenging. In a recent report, Wu and co‐workers described the first successful solution‐phase synthesis and isolation of crystalline circumcoronene derivatives, validating the long‐predicted Clar structure. Their synthetic approach enables preparation of new polycyclic benzenoid hydrocarbons with multiple K‐regions, which are difficult to obtain, and expands our understanding of the chemistry of these systems.
Synthesis of a renewable polyamine from canola oil by photocatalyzed thiol‐ene addition of cysteamine under green conditions
Authors: Echeverri David A. , Inciarte Helen C. , Cortés Natalia , Estenoz Diana A. , Polo Mara L. , Rios Luis A. 
Published: May 2023

AbstractA renewable polyamine was obtained by the photocatalyzed thiol‐ene addition of cysteamine hydrochloride (CAHC) to canola oil under mild conditions, using green solvents, a simple reaction system and a low‐power 365 UV lamp. A comparison of four different solvents was performed and the effect of one‐step and stepwise addition of CAHC to the reaction mixture was investigated. The solubilities of CAHC and oil in the solvent played a crucial role in the conversion of double bonds due to diffusion limitations and also due to changes in the opacity of the reaction mixture. Isopropanol showed a good solubility balance, dissolving well the oil and at the same time partially dissolving CAHC. During the one‐step addition of CAHC, the maximum conversions achieved were of 38.2% and 69% (in 24 h) with ethanol and isopropanol as solvents, respectively. The selectivity to the thiol‐ene product was very high with both solvents (i.e., 88%–90% at 4 h). The stepwise addition of CAHC significantly improved the double bond conversion (i.e., 93% at 24 h) using isopropanol as solvent. Finally, the polyamine was used as a comonomer in the aminolysis of a fatty cyclic carbonate affording a fully biobased elastomeric polyhydroxyurethane (PHU).
Aging characterization of different nitrile butadiene rubbers for sealing in a pneumatic system: Linking the change of the physicochemical state to the mechanical properties
Authors: Redon Adrien , Le Cam Jean‐Benoît , Robin Eric , Miroir Mathieu , Fralin Jean‐Charles 
Published: May 2023

AbstractNitrile butadiene rubbers (NBR) are widely used in sealing applications, such as O‐rings inside the pneumatic system of the French high‐speed train (TGV). In this application, a strong hardening of the NBRs alters the sealing function. Predicting the evolution of the mechanical properties during service life, especially the material hardening, is therefore a strategic issue to optimize time in maintenance operations of the TGV's pneumatic system. The main goal of this study is to reproduce the aging observed on a train's pneumatic system by performing thermo‐oxidative accelerated aging tests with different commercial nitrile rubbers at several temperatures and up to 2016 h. After achieving similar degradation to specimens aged on trains, aging mechanisms and effects have been investigated through different characterization techniques: infrared spectroscopy, swelling tests, X‐ray fluorescence spectrometry, differential scanning calorimetry, thermogravimetric analysis, and micro‐hardness measurements. The results obtained enabled us to identify and to relate aging mechanisms to aging conditions and to precisely determine and quantify the effects of physicochemical state evolution on the mechanical properties of each NBR considered. Extra crosslinks and oxidative functionalities form in the different elastomers, making them hard and brittle, and thus impacting the sealing function.
Efficient homology‐based annotation of transposable elements using minimizers
Authors: Gonzalez‐García Laura Natalia , Lozano‐Arce Daniela , Londoño Juan Pablo , Guyot Romain , Duitama Jorge 
Published: May 2023

AbstractPremiseTransposable elements (TEs) make up more than half of the genomes of complex plant species and can modulate the expression of neighboring genes, producing significant variability of agronomically relevant traits. The availability of long‐read sequencing technologies allows the building of genome assemblies for plant species with large and complex genomes. Unfortunately, TE annotation currently represents a bottleneck in the annotation of genome assemblies.Methods and ResultsWe present a new functionality of the Next‐Generation Sequencing Experience Platform (NGSEP) to perform efficient homology‐based TE annotation. Sequences in a reference library are treated as long reads and mapped to an input genome assembly. A hierarchical annotation is then assigned by homology using the annotation of the reference library. We tested the performance of our algorithm on genome assemblies of different plant species, including Arabidopsis thaliana, Oryza sativa, Coffea humblotiana, and Triticum aestivum (bread wheat). Our algorithm outperforms traditional homology‐based annotation tools in speed by a factor of three to >20, reducing the annotation time of the T. aestivum genome from months to hours, and recovering up to 80% of TEs annotated with RepeatMasker with a precision of up to 0.95.ConclusionsNGSEP allows rapid analysis of TEs, especially in very large and TE‐rich plant genomes.
Organic Covalent Interaction‐based Frameworks as Emerging Catalysts for Environment and Energy Applications: Current Scenario and Opportunities
Authors: Rasheed Tahir , Ahmad Hassan Adeel , Ahmad Tauqir , Khan Sardaraz , Sher Farooq 
Published: May 2023

AbstractThe term “covalent organic framework” (COF) refers to a class of porous organic polymeric materials made from organic building blocks that have been covalently bonded. The preplanned and predetermined bonding of the monomer linkers allow them to demonstrate directional flexibility in two‐ or three‐dimensional spaces. COFs are modern materials, and the discovery of new synthesis and linking techniques has made it possible to prepare them with a variety of favorable features and use them in a range of applications. Additionally, they can be post‐synthetically altered or transformed into other materials of particular interest to produce compounds with enhanced chemical and physical properties. Because of its tunability in different chemical and physical states, post‐synthetic modifications, high stability, functionality, high porosity and ordered geometry, COFs are regarded as one of the most promising materials for catalysis and environmental applications. This study highlights the basic advancements in establishing the stable COFs structures and various post‐synthetic modification approaches. Further, the photocatalytic applications, such as organic transformations, degradation of emerging pollutants and removal of heavy metals, production of hydrogen and Conversion of carbon dioxide (CO2) to useful products have also been presented. Finally, the future research directions and probable outcomes have also been summarized, by focusing their promises for specialists in a variety of research fields.
Microcystins at the tap: A closer look at unregulated drinking water contaminants
Authors: Stanton Beckye , Little Amy , Miller Lisa , Solomon Gina , Ryan Sarah , Paulukonis Susan , Cajina Stefan 
Published: May 2023

AbstractThis case study compared microcystins in tap water from 18 public water systems (PWSs) and 46 households with private intakes or nearshore wells (called self‐supplied water systems [SSWS]) from Clear Lake, California during a major cyanobacterial bloom in 2021. Microcystin concentrations were below the US EPA health advisory (HA; 0.3 μg/L) for PWS with Clear Lake intakes and for SSWS drawing from wells. However, for SSWS with Clear Lake intakes (intake SSWS), 24 of 79 microcystin samples collected were at or above the HA (maximum 3.9 μg/L). Further, microscopy showed that 20 of 28 tap samples (post‐treatment) from intake SSWS contained either cyanobacteria or algal cells. This demonstrates that robust multi‐barrier treatment systems at PWS reliably removed microcystins, while the less sophisticated treatment systems at intake SSWS were compromised during a major cyanobacterial bloom. Intake SSWS should consider alternative sources of drinking water, including physically connecting to an adjacent PWS or drilling a well.
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases
Authors: Carmona‐Rodríguez Lorena , Gajadhar Aaron S. , Blázquez‐García Irene , Guerrero Laura , Fernández‐Rojo Manuel A. , Uriarte Iker , Mamani‐Huanca Maricruz , López‐Gonzálvez Ángeles , Ciordia Sergio , Ramos Antonio , Herrero José Ignacio , Fernández‐Barrena Maite G. , Arechederra María , Berasain Carmen , Quiroga Jorge , Sangro Bruno , Argemi Josepmaría , Pardo Fernando , Rotellar Fernando , López Daniel , Barbas Coral , Ávila Matías A. , Corrales Fernando J. 
Published: May 2023

AbstractThe liver is the only solid organ capable of regenerating itself to regain 100% of its mass and function after liver injury and/or partial hepatectomy (PH). This exceptional property represents a therapeutic opportunity for severe liver disease patients. However, liver regeneration (LR) might fail due to poorly understood causes. Here, we have investigated the regulation of liver proteome and phosphoproteome at a short time after PH (9 h), to depict a detailed mechanistic background of the early LR phase. Furthermore, we analyzed the dynamic changes of the serum proteome and metabolome of healthy living donor liver transplant (LDLT) donors at different time points after surgery. The molecular profiles from both analyses were then correlated. Insulin and FXR‐FGF15/19 signaling were stimulated in mouse liver after PH, leading to the activation of the main intermediary kinases (AKT and ERK). Besides, inhibition of the hippo pathway led to an increased expression of its target genes and of one of its intermediary proteins (14‐3‐3 protein), contributing to cell proliferation. In association with these processes, metabolic reprogramming coupled to enhanced mitochondrial activity cope for the energy and biosynthetic requirements of LR. In human serum of LDLT donors, we identified 56 proteins and 13 metabolites statistically differential which recapitulate some of the main cellular processes orchestrating LR in its early phase. These results provide mechanisms and protein mediators of LR that might prove useful for the follow‐up of the regenerative process in the liver after PH as well as preventing the occurrence of complications associated with liver resection.
Response Surface Methodology‐Based Optimized Ultrasonic‐Assisted Extraction and Characterization of Selected High‐Value Components from Gemlik Olive Fruit
Authors: Ullah Sami , Anwar Farooq , Fayyaz ur Rehman Muhammad , Qadir Rahman , Safwan Akram Muhammad 
Published: May 2023

AbstractThis article presents an optimized ultrasound‐assisted ethanolic extraction (UAEE) and characterization of selected high‐value components from Gemlik olive fruit (GOF) harvested from Potohar region of Pakistan. Response surface methodology (RSM), involving central composite design (CCD), was applied to optimize the extraction variables i. e., temperature (25–65 °C), extraction time (15–45 min) and aqueous ethanol concentration (60–90 %) for optimal recovery of bioactives extract, total phenolic contents (TPC) and DPPH free radical scavengers. Under the optimized set of conditions such as 43 °C temperature, 32 min extraction time and 80 % aqueous ethanol, the best extract yield (218.82 mg/g), TPC (19.87 mg GAE/g) and DPPH scavenging activity (63.04 %) were recorded. A quadratic polynomial model was found to be reasonably fitted to the observed results for extract yield (p<0.0001 and R2=0.9941), TPC (p<0.0001 and R2=0.9891), and DPPH radical scavenging activity (p<0.0001 and R2=0.9692). Potent phenolic compounds were identified by GC/MS in GOF extract and considerable amount of essential fatty acids were also detected. The current findings support the use of UAEE as an effective green route for optimized recovery of high‐value components from GOF and hence its applications can be extended to functional food and nutra‐pharmaceutical developments.