bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidomic signature of stroke recurrence after transient ischemic attack
Authors: Purroy F. , Ois A. , Jove M. , Arque G. , Sol J. , Mauri-Capdevila G. , Rodriguez-Campello A. , Pamplona R. , Portero M. , Roquer J. 
Published: August 2023

AbstractWhile TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.
Quantifying synergistic interactions: a meta-analysis of joint effects of chemical and parasitic stressors
Authors: Cedergreen Nina , Pedersen Kathrine Eggers , Fredensborg Brian Lund 
Published: August 2023

AbstractThe global biodiversity crisis emphasizes our need to understand how different stressors (climatic, chemical, parasitic, etc.) interact and affect biological communities. We provide a comprehensive meta-analysis investigating joint effects of chemical and parasitic stressors for 1064 chemical-parasitic combinations using the Multiplicative model on mortality of arthropods. We tested both features of the experimental setup (control mortality, stressor effect level) and the chemical mode of action, host and parasite phylogeny, and parasite-host interaction traits as explanatory factors for deviations from the reference model. Synergistic interactions, defined as higher mortality than predicted, were significantly more frequent than no interactions or antagony. Experimental setup significantly affected the results, with studies reporting high (> 10%) control mortality or using low stressor effects (< 20%) being more synergistic. Chemical mode of action played a significant role for synergy, but there was no effects of host and parasite phylogeny, or parasite-host interaction traits. The finding that experimental design played a greater role in finding synergy than biological factors, emphasize the need to standardize the design of mixed stressor studies across scientific disciplines. In addition, combinations testing more biological traits e.g. avoidance, coping, and repair processes are needed to test biology-based hypotheses for synergistic interactions.
4-Amino-TEMPO loaded liposomes as sensitive EPR and OMRI probes for the detection of phospholipase A2 activity
Authors: Alberti Diego , Thiaudiere Eric , Parzy Elodie , Elkhanoufi Sabrina , Rakhshan Sahar , Stefania Rachele , Massot Philippe , Mellet Philippe , Aime Silvio , Geninatti Crich Simonetta 
Published: August 2023

AbstractThis work aims at developing a diagnostic method based on Electron Paramagnetic Resonance (EPR) measurements of stable nitroxide radicals released from “EPR silent” liposomes. The liposome destabilisation and consequent radical release is enzymatically triggered by the action of phospholipase A2 (PLA2) present in the biological sample of interest. PLA2 are involved in a broad range of processes, and changes in their activity may be considered as a unique valuable biomarker for early diagnoses. The minimum amount of PLA2 measured “in vitro” was 0.09 U/mL. Moreover, the liposomes were successfully used to perform Overhauser-enhanced Magnetic Resonance Imaging (OMRI) in vitro at 0.2 T. The amount of radicals released by PLA2 driven liposome destabilization was sufficient to generate a well detectable contrast enhancement in the corresponding OMRI image.
Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults
Authors: Park Yoonmi , Smith-Warner Stephanie A. , Zhang Xuehong , Park Yoon Jung , Kim Hyesook , Park Hyesook , Lee Hye Ah , Jung Seungyoun 
Published: August 2023

AbstractNon-alcoholic fatty liver disease (NAFLD) is the most common hepatic metabolic disorder in hypertensive adults. Impaired metabolism of micronutrients may increase NAFLD risk by exacerbating oxidative stress, insulin resistance, and inflammation among hypertensive adults. In this first cross-sectional analysis of 7,376 hypertensive adults with 2,015 NAFLD cases in the Korea National Health and Nutrition Examination Survey, vitamin and mineral supplements (VMS) use was identified via questionnaire. NAFLD was defined by a hepatic steatosis index > 36. Multivariable-adjusted odds ratios (MVOR) and 95% confidence intervals (CIs) were calculated using logistic regression models. In our study, 18.6% were current users of VMS; of these, 76.7% used multi-vitamin/mineral supplements. Current VMS users had significantly lower odds of NAFLD, compared with non-users (MVOR [95% CI]: 0.73 [0.58–0.92]). The inverse association became attenuated and non-significant among those consuming VMS at higher frequency (≥ 2 times/day), for longer duration (> 16 months), and taking ≥ 2 VMS products. The inverse association with current use of VMS was only evident in those aged < 56 years (MVOR [95% CI]: 0.54 [0.40–0.72]) and men (MVOR [95% CI]: 0.56 [0.40–0.80])(Pinteraction ≤ 0.04). Our results suggest that VMS use may lower NAFLD risk, particularly among younger or male hypertensive adults, if taken in moderation.
Modified polysulfone membrane facilitates rapid separation of plasma from whole blood for an effective anti-SARS-CoV-2-IgM diagnosis
Authors: Ijadi Bajestani Maryam , Ahmadzadeh Hossein 
Published: August 2023

AbstractDuring the outbreak of coronavirus, RT-PCR was the premier gold standard method for severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) diagnosis. However, the sophisticated procedure of RT-PCR persuades researchers to develop sustainable point-of-need immunoassay methods for tracing unwitting carriers of SARSCoV-2. Herein, by fabricating a modified polysulfone (MPSF) membrane, we developed an integrated radial flow immunoassay (IRFIA) platform as a point-of-care system, capable of multiplying the immunoassays at a short run time. The target molecule is the SARSCoV-2 IgM in separated plasma. Although the lateral flow immunoassay kits for the rapid identification of Covid-19 have already been commercially developed but, the proposed method is superior to the conventional lateral flow immunoassay. In the newly designed membrane system, we have combined the five membranes of prevalent lateral flow immunoassay (LFIA) strips in one polymeric membrane. The MPSF membrane is capable of separating plasma from whole blood sample, which will reduce the interference of red colour of hemoglobin with generated signal and enhance the immunoassay precision. The efficiency of plasma separation, reached the mean value of 97.34 v/v% in 5 s. Furthermore, the gel electrophoresis results of the separated plasma contrasted with centrifuged plasma sample, demonstrated more efficient separation by the membrane. Using the MPSF membrane, signal generation time reduced from about 20 min in conventional rapid test strip for Covid-19 to about 7 min in IRFIA platform. The sensitivity and specificity of the membrane platform were determined to be 89% and 90%, respectively and a Kappa coefficient of 0.79 showed reliable agreement between the RT-PCR and the membrane system.
Fs laser written volume Raman–Nath grating for integrated spectrometer on smartphone
Authors: Boisvert Jean-Sébastien , Loranger Sébastien , Kashyap Raman 
Published: August 2023

AbstractIn this work we demonstrate the integration of a spectrometer directly into smartphone screen by femtosecond laser inscription of a weak Raman–Nath volume grating either into the Corning Gorilla glass screen layer or in the tempered aluminosilicate glass protector screen placed in front of the phone camera. Outside the thermal accumulation regime, a new writing regime yielding positive refractive index change was found for both glasses which is fluence dependent. The upper-bound threshold for this thermal-accumulation-less writing regime was found for both glasses and were, respectively at a repetition rate less than 150 kHz and 101 kHz for fluence of 8.7 × 106 J/m2and 1.4 × 107 J/m2. A weak volume Raman–Nath grating of dimension 0.5 by 3 mm and 3 μm pitch was placed in front of a Samsung Galaxy S21 FE cellphone to record the spectrum using the 2nd diffraction order. This spectrometer covers the visible band from 401 to 700 nm with a 0.4 nm/pixel detector resolution and 3 nm optical resolution. It was used to determine the concentration detection limit of Rhodamine 6G in water which was found to be 0.5 mg/L. This proof of concept paves the way to in-the-field absorption spectroscopy for quick information gathering.
Spatial distribution and ecological niche modeling of geographical spread of Anopheles gambiae complex in Nigeria using real time data
Authors: Adeogun Adedapo , Babalola Ayodele Samuel , Okoko Okefu Oyale , Oyeniyi Tolulope , Omotayo Ahmed , Izekor Romoke Tawakalitu , Adetunji Oluwakemi , Olakiigbe Abiodun , Olagundoye Olalekan , Adeleke Monsuru , Ojianwuna Cynthia , Adamu Dagona , Daskum Abdullahi , Musa Jibrin , Sambo Obadiah , Adedayo Oduola , Inyama Petrus Uchenna , Samdi Lazarus , Obembe Abiodun , Dogara Musa , Kennedy Poloma , Mohammed Suleiman , Samuel Rebecca , Amajoh Chioma , Adesola Musa , Bala Mohammed , Esema Mary , Omo-Eboh Mamudu , Sinka Marianne , Idowu Olufunmilayo Ajoke , Ande Adeolu , Olayemi Israel , Yayo Abdulsalami , Uhomoibhi Perpetua , Awolola Samson , Salako Babatunde 
Published: August 2023

AbstractThe need for evidence-based data, to inform policy decisions on malaria vector control interventions in Nigeria, necessitated the establishment of mosquito surveillance sites in a few States in Nigeria. In order to make evidence-based-decisions, predictive studies using available data becomes imperative. We therefore predict the distribution of the major members of the Anopheles gambiae s.l. in Nigeria. Immature stages of Anopheles were collected from 72 study locations which span throughout the year 2020 resulted in the identification of over 60,000 Anopheline mosquitoes. Of these, 716 breeding sites were identified with the presence of one or more vector species from the An. gambiae complex and were subsequently used for modelling the potential geographical distribution of these important malaria vectors. Maximum Entropy (MaxEnt) distribution modeling was used to predict their potentially suitable vector habitats across Nigeria. A total of 23 environmental variables (19 bioclimatic and four topographic) were used in the model resulting in maps of the potential geographical distribution of three dominant vector species under current climatic conditions. Members of the An. gambiae complex dominated the collections (98%) with Anopheles stephensi, Anopheles coustani, Anopheles funestus, Anopheles moucheti, Anopheles nilli also present. An almost equal distribution of the two efficient vectors of malaria, An. gambiae and Anopheles coluzzii, were observed across the 12 states included in the survey. Anopheles gambiae and Anopheles coluzzii had almost equal, well distributed habitat suitability patterns with the latter having a slight range expansion. However, the central part of Nigeria (Abuja) and some highly elevated areas (Jos) in the savannah appear not suitable for the proliferation of these species. The most suitable habitat for Anopheles arabiensis was mainly in the South-west and North-east. The results of this study provide a baseline allowing decision makers to monitor the distribution of these species and establish a management plan for future national mosquito surveillance and control programs in Nigeria.
Influence of diatomite and its base modifications on the self-adhesive properties of silicone pressure-sensitive adhesives
Authors: Antosik Adrian Krzysztof , Mozelewska Karolina , Musik Marlena , Miądlicki Piotr 
Published: August 2023

AbstractThe study examined how diatomite and its modifications affected the self-adhesive ability of silicone pressure-sensitive adhesives. To create adhesive composition for testing, fillers were added to a commercial silicone resin, which were then used to create new modified pressure-sensitive tapes. The resulting tapes were tested to determine their adhesion, tack, cohesion at room and elevated temperature, SAFT test (Shear Adhesive Failure Temperature), pot-life (viscosity) and shrinkage. The results obtained were compared with those of the unmodified tapes. The tests resulted in higher thermal resistance (225 °C) and lower shrinkage (0.1%). As a result, we can conclude that materials with thermal resistance with a slight decrease in other parameters were obtained.
Understanding the impact of along-transect resolution on acoustic surveys
Authors: Boyra Guillermo , Paradinas Iosu , Rico Iñaki , Martínez Udane , Nogueira Enrique 
Published: August 2023

AbstractResolution can be defined as the minimum distance between two consecutive sampling points taken by an instrument. In acoustic surveys, the main parameter determining the resolution of sampling along a transect is the distance between successive echosounder transmissions or “pings”. An increase in either the time interval between pings or the speed of the vessel increases the inter-ping distance, hence decreasing the effective sampling resolution. This study investigated whether a loss in along-transect resolution affects the mean backscattered acoustic energy, leading to uncertainty and/or bias in abundance estimates. To this end, a real acoustic survey was echo-integrated, followed by the application of a systematic resampling scheme to simulate a decrease in pinging resolution. For each transect, the mean backscattered acoustic energy calculated at each resolution was compared with that at the original resolution. Transects were characterised according to their heterogeneity and spatial autocorrelation to investigate their effect on the relationship between abundance error and sampling resolution. Uncertainty was seen to increase with decreasing resolution, with higher heterogeneity and lower spatial autocorrelation accelerating the rise in imprecision. Although the mean bias across replicates was zero, the asymmetry of the bias distributions increased with decreasing resolution, leading to an increasing probability and magnitude of underestimation (https://aztigps.shinyapps.io/PingRateStudio/).
Effects of prior knowledge on brain activation and functional connectivity during memory retrieval
Authors: Guo Dingrong , Chen Haoyu , Wang Lingwei , Yang Jiongjiong 
Published: August 2023

AbstractPrevious studies have shown that the ventral medial prefrontal cortex (vmPFC) plays an important role in schema-related memory. However, there is an intensive debate to what extent the activation of subregions of the hippocampus is involved in retrieving schema-related memory. In addition, it is unclear how the functional connectivity (FC) between the vmPFC and the hippocampus, as well as the connectivity of the vmPFC with other regions, are modulated by prior knowledge (PK) during memory retrieval over time. To address these issues, participants learned paragraphs that described features of each unfamiliar word from familiar and unfamiliar categories (i.e., high and low PK conditions) 20 min, 1 day, and 1 week before the test. They then performed a recognition task to judge whether the sentences were old in the scanner. The results showed that the activation of the anterior-medial hippocampus (amHPC) cluster was stronger when the old sentences with high (vs. low) PK were correctly retrieved. The activation of the posterior hippocampus (pHPC) cluster, as well as the vmPFC, was stronger when the new sentences with high (vs. low) PK were correctly rejected (i.e., CR trials), whereas the cluster of anterior-lateral hippocampus (alHPC) showed the opposite. The FC of the vmPFC with the amHPC and perirhinal cortex/inferior temporal gyrus was stronger in the high (vs. low) PK condition, whereas the FC of the vmPFC with the alHPC, thalamus and frontal regions showed the opposite for the CR trials. This study highlighted that different brain networks, which were associated with the vmPFC, subregions of the hippocampus and cognitive control regions, were responsible for retrieving the information with high and low PK.
A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions
Authors: Petkantchin Remy , Rousseau Alexandre , Eker Omer , Zouaoui Boudjeltia Karim , Raynaud Franck , Chopard Bastien ,   the INSIST investigators, Majoie Charles , van Bavel Ed , Marquering Henk , Arrarte-Terreros Nerea , Konduri Praneeta , Georgakopoulou Sissy , Roos Yvo , Hoekstra Alfons , Padmos Raymond , Azizi Victor , Miller Claire , van der Kolk Max , van der Lugt Aad , Dippel Diederik W. J. , Lingsma Hester L. , Boodt Nikki , Samuels Noor , Payne Stephen , Jozsa Tamas , El-Bouri Wahbi K. , Gilvarry Michael , McCarthy Ray , Duffy Sharon , Dwivedi Anushree , Fereidoonnezhad Behrooz , Moerman Kevin , McGarry Patrick , Staessens Senna , de Meyer Simon F. , Vandelanotte Sarah , Migliavacca Francesco , Dubini Gabriele , Luraghi Giulia , Rodriguez Matas Jose Felix , Bridio Sara , Chopard Bastien , Raynaud Franck , Petkantchin Rémy , Blanc-Guillemaud Vanessa , Panteleev Mikhail , Shibeko Alexey , Zouaoui Boudjeltia Karim 
Published: August 2023

AbstractOne of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: intravenous or intravascular thrombolysis. However, this procedure is not without risk for the patient; the worst circumstances can cause a brain hemorrhage or embolism that can be fatal. Improvement in patient management drastically reduced these risks, and patients who benefited from thrombolysis soon after the onset of the stroke have a significantly better 3-month prognosis, but treatment success is highly variable. The causes of this variability remain unclear, and it is likely that some fundamental aspects still require thorough investigations. For that reason, we conducted in vitro flow-driven fibrinolysis experiments to study pure fibrin thrombi breakdown in controlled conditions and observed that the lysis front evolved non-linearly in time. To understand these results, we developed an analytical 1D lysis model in which the thrombus is considered a porous medium. The lytic cascade is reduced to a second-order reaction involving fibrin and a surrogate pro-fibrinolytic agent. The model was able to reproduce the observed lysis evolution under the assumptions of constant fluid velocity and lysis occurring only at the front. For adding complexity, such as clot heterogeneity or complex flow conditions, we propose a 3-dimensional mesoscopic numerical model of blood flow and fibrinolysis, which validates the analytical model’s results. Such a numerical model could help us better understand the spatial evolution of the thrombi breakdown, extract the most relevant physiological parameters to lysis efficiency, and possibly explain the failure of the clinical treatment. These findings suggest that even though real-world fibrinolysis is a complex biological process, a simplified model can recover the main features of lysis evolution.
Myosteatosis as a prognostic factor of Mycobacterium avium complex pulmonary disease
Authors: Chung Eunki , Park Youngmok , Kim Song Yee , Park Moo Suk , Kim Young Sam , Lee Hye-Jeong , Kang Young Ae 
Published: August 2023

AbstractQuantitative body composition affects the prognosis of patients with Mycobacterium avium complex pulmonary disease (MAC-PD). However, whether the qualitative body composition obtained indirectly through computed tomography (CT) affects their prognosis is debatable. We retrospectively analyzed patients with MAC-PD who underwent non-contrast CT at MAC-PD diagnosis. The cross-sectional area of the erector spinae muscle (ESM area), the Hounsfield unit of the erector spinae muscle (ESM HU), and the cross-sectional area of subcutaneous fat (SQF area) were measured at the level of the first lumbar vertebra. Myosteatosis were defined below the median value of ESM HU for each sex. Of 377 patients, 45 (11.9%) died during the follow-up. Patients who died were older and had a lower ratio of females (33.3%). In body compositions, SQF area and ESM HU were lower in the patients who died. In multivariable analysis, a low ESM HU was associated with increased mortality (ESM HU adjusted hazard ratio [aHR] 0.95, 95% confidence interval [CI] 0.93–0.97) through body composition. SQF area revealed protective effects in MAC-PD patients with body mass index ≥ 18.5 kg/m2 (aHR 0.98, 95% CI 0.95–1.00). In conclusion, the decrease in ESM HU, which indirectly reflects myosteatosis, is associated with mortality in patients with MAC-PD.
Analysis of carbon emission drivers and multi-scenario projection of carbon peaks in the Yellow River Basin
Authors: Wang Liangmin , Xue Weixian 
Published: August 2023

AbstractThe Yellow River Basin is a key ecological barrier and commercial zone in China, as well as an essential source of energy, chemicals, raw materials, and fundamental industrial foundation, the achievement of its carbon peaking is of great significance for China’s high-quality development. Based on this, we decomposed the influencing factors of carbon dioxide emissions in the Yellow River Basin using the LMDI method and predicted the carbon peaking in the Yellow River Basin under different scenarios using the STIRPAT model. The results show that (1) the energy intensity effect, economic activity effect and population effect play a positive role in promoting carbon emissions during 2005–2020. The largest effect on carbon emissions is the population size effect, with a contribution rate of 65.6%. (2) The STIRPAT model predicts that the peak of scenarios “M–L”, “M–M” and “M–H” will occur in 2030 at the earliest. The “M–H” scenario is the best model for controlling carbon emissions while economic and social development in the Yellow River Basin. The results of this paper can provide a theoretical basis for the development of a reasonable carbon peak attainment path in the Yellow River Basin and help policy makers to develop a corresponding high-quality development path.