bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of reconstruction plate in surgical treatment of primary and secondary tumors of the mandible
Authors: Kropotov M. A. , Yakovleva L. P. , Saprina O. A. , Safarov A. A. 
Published: June 2023

Introduction.Squamous cell carcinoma of the oral mucosa advances into the mandible in locally advanced tumors in 13–38 % of cases. Frequently, this situation requires inclusion of segmental resection of the mandible into the surgical plan. This approach requires adequate reconstruction for preservation of satisfactory functional and esthetic treatment results. Selection of reconstruction method remains an important clinical problem in everyday practice of a head and neck cancer specialist.Aim.To analyze clinical materials on the use of reconstruction plates in oncological practice, evaluate esthetic and functional results of their use in patients who underwent single-stage reconstruction after segmental resection of the mandible.Materials and methods.The results of treatment of 103 patients after segmental resection of the mandible with defect reconstruction using only a reconstruction plate or a reconstruction plate with a distant or free flap who were treated at the Loginov Moscow Clinical Scientific Center and N.N. Blokhin Scientific Medical Research Center of Oncology between 1998 and 2019 were analyzed.Results.Complications at various times (between 2 months and 3 years) were observed in 15 (14.6 %) patients. The most frequent complications were plate cutting through the skin and mucosa (6 (5.8 %) cases) and osteomyelitis of fragments of the mandible (7 (6.7 %) cases). In 2 (1.9 %) cases, plate fracture was observed. It is necessary to note that during anti-inflammatory treatment in 4 (3.9 %) patients, osteomyelitis was managed while 11 (10.7 %) patients required removal of the reconstruction plate. Per the data analysis, in patents with surgical defect in the anterior area (defects ТТ, АТТ, САТ per the J.S. Brown classification, 2016) complications are significantly more common (in 11 (23.9 %) of 46 cases) than in patients with limited defects of the body and condyle (defects АТ, АС) (in 4 (7.0 %) of 57 cases). The rate of complications is also significantly affected by radiation dose.Conclusion.Therefore, use of a plate for reconstruction of mandible defect is aesthetically and functionally acceptable reconstruction technique. Severe complications leading to plate removal are rare and were observed in 11 (10.7 %) patients.
Self-assessment of health status in patients with complicated type 2 diabetes mellitus is one of quality of life components
Authors: Demicheva T. P. , Smirnova E. N. 
Published: June 2023

Objective. To identify the characteristics of the subjective health status in patients with complicated type 2 diabetes mellitus (DM) based on the survey data.
Materials and methods. 387 women with type 2 DM having microvascular complications were examined; the control group patients without DM (118 persons).
Results. The study showed that for women with complicated type 2 diabetes, physical activity restrictions were more significant than mental ones. They were 18 times more likely (95 % CI [3.25; 99.65], p 0.05) to have physical problems than mental health problems. Subjective assessment of deterioration in physical condition depended on the duration of the disease, and not on age. There was no relationship between the components of the quality of life and indicators of carbohydrate metabolism, body mass index, waist circumference. Patients with type 2 DM are worse adapted in the society, there is observed a reduced level of "social activity" (58.11.8 versus 63.22.3; p=0.05, respectively).
Conclusions. The low quality of life, from the point of view of patients with complicated type 2 diabetes, is associated with physical and mental components. Limited physical activity in comparison with mental is more significant for patients. The lack of relationship between the quality of life indicators and objective data makes it possible to assert that their improvement does not influence the subjective assessment of a patient that is important for physicians to consider.
Correlation between type 2 diabetes mellitus and pancreatic steatosis
Authors: Tanaeva T. A. , Ivanov L. A. 
Published: June 2023

Objective. To study the features of endocrine function in non-alcoholic fatty disease of the pancreas in patients with chronic pancreatitis in remission.
Materials and methods. There were examined 62 patients with chronic pancreatitis without exacerbation, who were admitted to the day hospital department of the City Clinical Hospital № 9 (Izhevsk). The data of laboratory and instrumental research methods, the features of the pancreatic endocrine function in patients with chronic pancreatitis, accompanied by fatty degeneration of the organ were analyzed.
Results. Pancreatic steatosis was detected in 80.8 % of cases in patients with chronic pancreatitis in remission with metabolically complicated obesity. Violation of endocrine function was diagnosed in 19.3 % of cases. In the presence of insulin resistance, 6 (16.7 %) of the examined patients were diagnosed type 2 diabetes for the first time. At high insulin levels, 4 (6.5 %) patients had no changes in the indicators of fasting sugar.
Conclusions. All patients with increased insulin resistance and metabolically complicated obesity require a comprehensive clinical and laboratory-instrumental study for the early detection of non-alcoholic fatty pancreatic disease. When establishing the signs of fatty degeneration of the pancreas, dispensary observation as well as prophylactic and therapeutic measures are necessary to prevent the development of type 2 diabetes mellitus.
Young People's Expectations Towards a High School Catechist − Research Report
Authors: Zubrzycka-Maciąg Teresa 
Published: June 2023

English translation. The original article can be found here
Religion teachers play a unique role in educating the young generation. In addition to the tasks assigned to all teachers in general, they are to support students in their spiritual development, conditioning their ability to understand themselves, build their own identity, and give meaning to their lives. Catechists face a difficult task, because young people, although they are very interested in religion and spirituality, also have many doubts, questions, and dilemmas in this sphere. The article aims to present the expectations of high school students towards catechists related to their personality traits, skills, psychosocial competencies, and their approach to pupils. Data obtained in a survey conducted with a group of 70 high school graduates show that young people need a catechist whom they can trust in the most important matter, which is the meaning of human life. Thus, they expect catechists to give a credible testimony of faith, have good substantive preparation, treat them subjectively like partners, and are ready to undertake an open dialogue with them.
Prognosis in patients with cardiorenal syndrome depending on the clinical form of atrial fibrillation
Authors: Polyanskaya E. A. 
Published: June 2023

Background. Atrial fibrillation (AF) is the most common stable arrhythmia in the population. The interaction of AF and cardiorenal syndrome is poorly understood, despite the fact that the proportion of such patients with combined heart and kidney damage reaches 60% among people with chronic heart failure (CHF). Data on the long-term prognosis in patients with cardiorenal syndrome depending on the form of AF is not enough.Objective. To assess the prognosis in patients with cardiorenal syndrome depending on the clinical form of AF.Design and methods. 126 patients with verified cardiorenal syndrome and various forms of AF were included. An observational study was performed with the fixation of hospitalizations for CHF and other cardiovascular events, including deaths.Results. The rate of onset of the first end point is higher in patients with permanent AF (8.5 [3.0; 18.5] months and 15.0 [5.0; 24.0] months, p < 0.001). Analysis of survival curves shows a worse prognosis in patients with permanent AF.Conclusion. In patients with cardiorenal syndrome in combination with AF, its clinical form has a significant impact on the long-term prognosis. Permanent AF, to a greater extent than paroxysmal/persistent AF, in conditions of cardiorenal syndrome is associated with faster and more frequent development of new cardiovascular events, including hospitalizations for decompensated CHF and deaths.
Role of 11C-choline PET/CT in parathyroid adenomas’ localization in patients with primary hyperparathyroidism
Authors: Pogosian K. A. , Karonova T. L. , Ryzhkova D. V. , Yanevskaya L. G. , Tsoy U. A. , Yudina O. V. , Ivanikha E. V. , Grineva E. N. 
Published: June 2023

Background. Topical diagnosis of primary hyperparathyroidism (PHPT) remains an urgent problem due to the high incidence of persistence and recurrence after surgical treatment. At the preoperative stage, a search for the parathyroid hormone hyperproduction source is performed using instrumental methods: ultrasound, scintigraphy of the parathyroid glands (PTG) and multislice computed tomography (MSCT). The cause of PHPT persistence and recurrence after parathyroidectomy may be the multiple nature of PTG lesions or their ectopic location. Additional methods of visualization of PTG adenomas can be used to improve diagnosis (PET/CT).Objective. To compare the sensitivity and specificity of PET/CT with 11C-choline with the traditional visualization techniques.Design and methods. 16 PHPT patients were analyzed. All patients underwent US, subtraction scintigraphy with 99mTc-technetril/99mTc-pertechnitate and CT were performed in 12 and 16 patients, respectively. 11C-choline PET/CT was used for all patients. Imaging results’ coincidence of two methods were labeled as the true one.Results. The sensitivity of PET/CT with 11C-choline was 94 %, CT, subtraction scintigraphy with 99mTc-technetril/99mTc-pertechnitate and US — 75 %, 69 % and 63 %, respectively. The specificity of PET/CT with 11C-choline, CT, scintigraphy with 99mTc-technetril/99mTc-pertechnitate, and US was 100 %, 84 %, 76 %, and 68 %, respectively.Conclusion. PET/CT with 11C-choline demonstrated best sensitivity and specificity among all methods and can become an alternative in PHPT diagnostics in case of negative or inconvclusive results of previous visualization.
Vitamin D metabolism parameters in hospitalized COVID-19 patients
Authors: Mikhailova A. A. , Golovatyuk K. A. , Lagutina D. I. , Chernikova A. T. , Vasilieva E. Yu. , Bykova E. S. , Karonova T.  L. 
Published: June 2023

Background. Recently, clinical benefits among COVID-19 patients, received vitamin D were demonstrated. Features of vitamin D metabolism in the acute period of COVID-19 remain unclear.Objective. To assess the level of 25(OH)D and 1,25(OH)2D in hospitalized COVID-19 patients and cholecalciferol effect on the vitamin D metabolites dynamic.Materials and methods. Group 1 (n = 22) patients received cholecalciferol bolus therapy at a total dose of 100,000 IU. Group 2 patients (n = 22) did not receive cholecalciferol supplementation. Serum 25(OH)D and 1,25(OH)2D levels were estimated for each group on the first and the ninth day of hospitalization.Results. On the ninth day of hospitalization 25(OH)D serum level demonstrated the 45.8 % rise in the Group 1, while in the Group 2 there was a decrease in the 25(OH)D level by 17.9%. At the same time, dynamic evaluation of the 1.25(OH)2D level did not show any differences between the groups, while pairwise comparison on the first and on the ninth days of hospitalization revealed an increase in the active metabolite concentration (p < 0.001) in both groups.Conclusion. Such vitamin D metabolism parameters in the acute period of COVID-19 may be associated with a 1α-hydroxylase activity alteration. Thus, 1.25(OH)2D serum level increase regardless of vitamin D status during the hospitalization could be explained by the COVID-19 course or concomitant corticosteroid medication.
La forêt et la faune de Côte d’Ivoire dans une situation alarmante – Synthèse des résultats de l’Inventaire forestier et faunique national
Authors: CUNY Pascal , PLANCHERON Françoise , BIO Abraham , KOUAKOU Elvis , MORNEAU François 
Published: June 2023

La Côte d’Ivoire a engagé début 2019 un inventaire national de ses forêts et de sa faune, accompagné par des enquêtes socio-économiques auprès des agriculteurs. Cet inventaire, déployé sur l’ensemble du territoire, fournit une grande quantité d’informations. Il montre que l’état des forêts et de la faune est fortement dégradé et que les cultures industrielles (cacaoyer, hévéa, palmier à huile dans le sud, anacardier et coton dans le centre et le nord) sont devenues dominantes. La superficie de la forêt en Côte d’Ivoire est estimée en 2020 à 2,97 millions d’hectares, soit 9,2 % de la surface totale du territoire, dont 2,88 millions d’hectares de forêt (dite) naturelle et un peu plus de 92 000 ha de reboisement. Le taux de déforestation moyen annuel depuis 1986 est de 2,8 % (superficie de la forêt en 1986 de 7,85 millions d’hectares). La superficie de la forêt dans les forêts étatiques, dites forêts classées, n’est plus que de 13,3 % alors que la création des forêts classées dans les années 1970 avait pour objectif la préservation et la gestion durable des forêts. La raréfaction, voire la disparition, des essences commerciales ne permet plus de mettre en œuvre une exploitation forestière respectant les critères de gestion durable. Les aires protégées (parcs nationaux, réserves) ne contiennent plus que 32,2 % de forêt. En outre, des transects d’observation de la faune déployés sur tout le territoire ont permis de montrer que la faune commune (aulacode, guib harnaché, lièvre, etc.) est encore bien présente. En revanche, les grands mammifères (antilopes, éléphants, singes) sont cantonnés dans quelques aires protégées et forêts classées avec des tailles de population souvent critiques. Enfin, l’analyse socio-économique montre que les forêts classées sont occupées par une population humaine composée à 50 % d’allogènes, à 28 % d’autochtones et à 22 % d’allochtones : le cacao occupe la plus grande partie des cultures installées majoritairement par les allogènes. Dans le domaine rural, ce sont surtout les autochtones (76 %) qui s’investissent dans l’agriculture (principalement l’anacarde), suivis des allogènes (13 %) et des allochtones (11 %). L’état des écosystèmes forestiers et de leur faune est alarmant, mais des mesures fortes prises rapidement pourraient permettre d’améliorer cette situation au moins dans les secteurs les mieux préservés. La poursuite de campagnes d’inventaire régulières sera un outil essentiel pour mesurer l’impact de ces décisions.
Contribution à l’étude de la variabilité chez le cèdre de l’Atlas au Maroc
Authors: EL BAKKALI Nezha 
Published: June 2023

Le cèdre de l'Atlas (Cedrus atlantica (Endl.) G. Manetti ex Carrière) est une espèce endémique des montagnes du Maroc et de l’Algérie. Il constitue une ressource vitale pour les populations et d’intérêt bioécologique et socio-économique considérable. Cette ressource naturelle est malheureusement menacée par plusieurs facteurs de dépérissement et l’évolution rapide du climat vers la sécheresse, ce qui le pousse à modifier sa morphologie pour acquérir des caractères d’adaptation. Dans cette thèse, l’identification des traits morphologiques et anatomiques adaptatifs de Cedrus atlantica au Maroc est abordée via :

L'évaluation de l’adaptabilité écologique et la microévolution des populations naturelles de atlantica basée sur l'analyse des caractères morphologiques et anatomiques des aiguilles.
L’étude de certains caractères adaptatifs des aiguilles des populations du cèdre dans le Moyen Atlas central présentant des conditions environnementales et des niveaux de diversité génétiques différents.
L’étude morphométrique effectuée sur des caractères morpho-anatomiques de l'aiguille dans des populations naturelles dans les montagnes du Moyen et du Haut Atlas au Maroc.

Les résultats de l’évaluation de l’influence de la géographie sur la morphologie et l’anatomie des aiguilles du C. atlantica montrent l’existence d’une adaptation de la structure des aiguilles à la position géographique et aux conditions climatiques des populations. De même, les populations du Moyen Atlas central présentant des conditions environnementales et des niveaux de diversité génétiques différents ont montré que les adaptations morpho-anatomiques des aiguilles sont en harmonie avec leur spécificité génétique révélée précédemment. Enfin, l’étude comparative de la variabilité morpho-anatomique des aiguilles des populations du Moyen et du Haut Atlas a confirmé l'existence de deux écotypes distincts génétiquement de C. atlantica, géographiquement distants dans les montagnes de l'Atlas. En conséquence, cela a permis de cerner l'écotype en conférant à cette espèce une place de choix dans les projets de revalorisation des populations méditerranéennes, en particulier sur les zones semi-arides. Ces résultats montrent que les traits morpho-anatomiques des aiguilles permettent l’évaluation de la diversité intra- et inter-population chez le cèdre de l’Atlas. De plus, ils ont une importance capitale dans les programmes de sélection ainsi que dans les études relatives à la microévolution du genre Cedrus au Maroc.
Neurologic Outcomes After Radiation Therapy for Severe Spinal Cord Compression in Multiple Myeloma
Authors: Zijlstra H. , Striano B.M. , Crawford A.M. , Groot O.Q. , Raje N. , Tobert D.G. , Patel C.G. , Wolterbeek N. , Delawi D. , Kempen D.H.R. , Verlaan J.J. , Schwab J.H. 
Published: June 2023

Background:
Bone destruction is the most frequent disease-defining clinical feature of multiple myeloma (MM), resulting in skeletal-related events such as back pain, pathological fractures, or neurologic compromise including epidural spinal cord compression (ESCC). Up to 24% of patients with MM will be affected by ESCC. Radiation therapy has been proven to be highly effective in pain relief in patients with MM. However, a critical knowledge gap remains with regard to neurologic outcomes in patients with high-grade ESCC treated with radiation.

Methods:
We retrospectively included 162 patients with MM and high-grade ESCC (grade 2 or 3) who underwent radiation therapy of the spine between January 2010 and July 2021. The primary outcome was the American Spinal Injury Association (ASIA) score after 12 to 24 months, or the last known ASIA score if the patient had had a repeat treatment or died. Multivariable logistic regression was used to assess factors associated with poor neurologic outcomes after radiation, defined as neurologic deterioration or lack of improvement.

Results:
After radiation therapy, 34 patients (21%) had no improvement in their impaired neurologic function and 27 (17%) deteriorated neurologically. Thirty-six patients (22%) underwent either surgery or repeat irradiation after the initial radiation therapy. There were 100 patients who were neurologically intact at baseline (ASIA score of E), of whom 16 (16%) had neurologic deterioration. Four variables were independently associated with poor neurologic outcomes: baseline ASIA (odds ratio [OR] = 6.50; 95% confidence interval [CI] = 2.70 to 17.38; p < 0.001), Eastern Cooperative Oncology Group (ECOG) performance status (OR = 6.19; 95% CI = 1.49 to 29.49; p = 0.015), number of levels affected by ESCC (OR = 4.02; 95% CI = 1.19 to 14.18; p = 0.026), and receiving steroids prior to radiation (OR = 4.42; 95% CI = 1.41 to 16.10; p = 0.015).

Conclusions:
Our study showed that 38% of patients deteriorated or did not improve neurologically after radiation therapy for high-grade ESCC. The results highlight the need for multidisciplinary input and efforts in the treatment of high-grade ESCC in patients with MM. Future studies will help to improve patient selection for specific and standardized treatments and to clearly delineate which patients are likely to benefit from radiation therapy.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Secondary Peripheral Dedifferentiated Chondrosarcoma
Authors: Yoshimoto Masato , Setsu Nokitaka , Yokoyama Nobuhiko , Taguchi Kenichi , Kohashi Kenichi , Oda Yoshinao 
Published: June 2023

Case:
In a 54-year-old man, imaging findings suggested a malignant bone tumor having 2 distinct components of the left ilium. Histopathologically, the resected tumor was diagnosed as dedifferentiated chondrosarcoma (CS) arising in secondary peripheral CS.

Conclusion:
Dedifferentiated CS consists of a high-grade noncartilaginous sarcoma adjacent to a preexisting low-grade CS, among which the peripheral type is extremely rare. Because the bimorphic imaging findings reflected the dedifferentiated area and the CS area, they were considered useful for diagnosis. In addition, the dedifferentiated area was localized to the tumor’s edge, suggesting that the dedifferentiation originated from the cartilage cap.
Ranking the reactivity of carbon sources in cattle slurry in modulating N-gas emissions
Authors: MA YAN , Chadwick Dave R. , Chen Qing , López-Aizpún María , Scholefield David , Hawkins Jane , Dlamini Jerry C. , Segura Carmen , Cardenas Laura M. 
Published: June 2023

Abstract

Animal manures are important sources of nutrients for crop production, yet the effects of slurry carbon (C) components on soil nitrogen gaseous emissions are poorly understood. Six experiments were conducted in a He/O2 atmosphere aiming to determine the effects of cattle slurry and some of its C components on soil nitrous oxide (N2O) and dinitrogen (N2) emissions. The treatments were: 1) NO3−; 2) NO3− + glucose (experiments 1 to 4) or NO3− + NH4+ (experiments 5 and 6); and 3) NO3− + C source (this was either vanillin, cellulose, glucosamine, butyric acid, fresh cattle slurry or aged cattle slurry, experiments 1 to 6). Results showed that the reactivity order of individual C sources on total N2O-N + N2-N emissions was: glucose > glucosamine > butyric acid > vanillin > aged slurry > cellulose > fresh slurry. Aged cattle slurry generated relatively higher soil total N2O-N + N2-N emissions, but also further reduction to N2 than fresh cattle slurry after incorporation into the soil. In addition, the N2O/N2 ratio was relatively higher in the NO3− + NH4+ treatments (experiments 5 and 6), as well as in the NO3− + glucosamine treatment, due to the additional N application. We concluded that the availability/degradability of C in slurry is an important control of subsequent denitrification rates and the production and emission of N2O when applied to land suggesting that slurry management, i.e. storage period, can be optimised to influence C availability in cattle slurry, leading to a reduced risk of N2O production.