bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-52 Cognitive Functioning After Concussion is Associated with Academic Problems and School Stress
Authors: Richie R , Terheyden van S , Vaughan C , Gioia G 
Published: June 2023

Abstract

Purpose
Students experiencing concussion symptoms also report school difficulties and academic impacts. We examined the relationship of cognitive functioning with self-reported academic concerns and school stress, hypothesizing that students with lower working memory (WM) and processing speed (PS) scores would have higher reported academic concerns and greater school stress.

Methods
184 youth aged 8 to 18 diagnosed with a concussion (Mean age=14.4±2.2, 51% female, 67% white) completed the Concussion Learning Assessment and School Survey, 3rd Edition (CLASS-3), a validated self-reported rating scale of post-concussion academic problems and school stress. Pearson’s partial correlations, controlling for age and sex, assessed the relationship between the Academic Problems and School Stresses scales from the CLASS-3 with the WMI and PSI from the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) and Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V).

Results
There were negative correlations between Processing Speed and Academic Problems (r(144)=-.33, p&lt;.001) and School Stresses (r(160)=-.29, p=&lt;.001). There was also a negative correlation between Working Memory and School Stresses (r(162)=-.24, p=.002) and Academic Problems (r(144)=-.15, p=.07).

Conclusions
Students with lower working memory and processing speed tend to report higher academic problems and school stresses. These results suggest that students with lower cognitive function experience higher school concerns, implying a need to establish appropriate school supports, particularly in students who experience cognitive dysfunction after a concussion.
A-55 Updated validation of the accuracy of reaction time assessment on computer-based tablet devices
Authors: Schatz P , Cuzzupe J , Leitner D L 
Published: June 2023

Abstract

Purpose
Computer-based assessment continues to evolve, migrating from paper- to computer- to tablet-based assessment/devices. Despite the increase in tablet ownership and use, there remains limited research validating their timing accuracy. The purpose of this study was to update previous (2015) research documenting timing delays on touchscreen devices.

Methods
Delays between stimulus presentation and (simulated) touch response were recorded using an custom-made timing device and a Javascript-based timer using an Acer Chromebook (Spin 211; Chrome OS 98.0), an 8th generation Apple iPad(iOS 15.4), a Kindle Fire HD 10 (Fire OS 7.3), and a Samsung Galaxy A7 (Android OS 11.0) at response intervals of 100, 250, 500, 1000 milliseconds (ms).

Results
The Chrome browser was consistently the fastest browser on the Acer and Samsung devices, and similar to Safari (Apple iPad) and Firefox (Samsung Galaxy). Using the Chrome browser, results showed significantly greater timing error on the Samsung tablet (88-105ms), than Kindle Fire (65-70ms), Apple iPad (49-54s) and Acer Chromebook (36-41ms), across all response intervals.

Conclusions
Due to inherent timing delays, touchscreen devices are not recommended for collection of simple RT. For choice RT measures on tablet devices, the Safari browser (Apple iOS devices) and Chrome Browser (Chromebooks or Kindle Fire) are recommended. However, use of the Samsung Galaxy tablets (any browser) and Kindle Fire (Silk browser) are not recommended.
A-60 Gender and Age Differences on the Sway Medical Mobile Balance Test
Authors: Stephenson K , Caccese J B , Cook N E , Berkner P , Iverson G L 
Published: June 2023

Abstract

Purpose
To determine if performance on the Sway Medical Mobile Application Balance Test differs by age and gender.

Methods
Pre-season baseline data from 33,784 individuals (51.3% girls/women) between ages 12 and 22 (mean=16.8 years, SD=2.5), tested in the summer of 2022, without a self-reported concussion in the past 6 months, and without self-reported ADHD were examined. Three Spearman correlations were used to assess the association between balance scores and age for the total sample, and for the boys/men and girls/women groups separately. Twelve Mann-Whitney U tests were used to compare genders on balance scores within each age group (12, 13, 14, through 22-years-old) and for the total sample. A Bonferroni correction was used to adjust for multiple comparisons, and the level of significance was set at p=0.004.

Results
There was a positive correlation between higher (i.e., better) balance scores and older age for the total sample (r=.25, p&lt;.001), and within the boys/men (r=.30, p&lt;.001) and girls/women groups separately (r=.21, p&lt;.001). For every age, there was a significant difference between boys/men and girls/women on balance test scores, with girls/women obtaining higher (i.e., better) balance scores than boys/men. Effect sizes for these differences ranged from small to medium (Hedge’s g=.29-.65).

Conclusions
There are age and gender-related differences on baseline Sway Medical Mobile Balance Test scores. Girls/women performed better on the balance testing compared to boys/men at all ages. Additionally, the balance scores improved throughout adolescence and generally plateaued in early adulthood (18-22-years-old).
A-62 Evaluating the New Consensus Criteria for Traumatic Encephalopathy Syndrome in Older Adults
Authors: Terry D P , Jo J , Williams K , Davis P , Iverson G L , Zuckerman S L 
Published: June 2023

Abstract

Purpose
To evaluate the new consensus diagnostic criteria for Traumatic Encephalopathy Syndrome (TES) in community-dwelling older adults, with and without a history of repetitive head impacts.

Methods
Older adults (n=507; age: M=70.0, SD=9.0; 65% women) completed a survey assessing TES, as well as their demographics, prior athletic participation, and current symptoms in a variety of areas. To meet the symptom criteria for TES, participants had to report progressive changes with memory, executive functioning, or neurobehavioral dysregulation. To meet the repetitive head impacts criterion, participants reported contact sport exposure (5+ years of contact sports, at least 2 of which were in high school) or other repetitive head impacts (e.g., from military exposures or domestic violence).

Results
Overall, 26.2% endorsed having one or more of the progressive core clinical features of TES. Those who met the repetitive head impacts criterion were not significantly more likely to meet TES criteria compared to those who did not meet this criterion (31.8% vs. 25.3%, p=.26). In a binary logistic regression predicting TES status, current depression or anxiety (OR=8.00), history of psychiatric disorders (OR=2.48), male sex (OR=1.85), and sleep problems (OR=1.75) were associated with meeting TES criteria. The repetitive head impacts criterion, age, and current pain were not significantly associated with TES status.

Conclusions
About one-fourth of older adults met the symptoms criteria for TES, many of whom did not have a history of repetitive mild neurotrauma. Mental health problems and sleep issues were associated with TES, whereas having a history of repetitive head impacts was not.
A-66 Clinical Neuropsychology Journal Articles about Concussion from 2010-2020
Authors: Whaley M C , Ready R 
Published: June 2023

Abstract

Purpose
Concussions are a major public health concern and are caused by falls, motor vehicle accidents, sports-related injuries, and assaults. Concussion research increased dramatically in recent decades, with 1,015 articles about concussion listed in PubMed in 2020, up from 30 in 2000. The focus of concussion research is evolving from assessment tools towards education, biomarkers, and intervention. Little is known about the topics of concussion research in clinical neuropsychology, but this knowledge might direct research efforts in the future.

Data Selection
We coded the content of titles of concussion articles published in 12 clinical neuropsychological journals from 2010-2020. This project is part of a study about the cultural and multicultural content of clinical neuropsychology articles. From this larger dataset, titles that included the terms concussion, sub-concussive, mild traumatic brain injury were collected (n=317).

Data Synthesis
Content in titles for concussions articles were, in order, sports (29.0%), children/adolescents (23.3%), emotion and personality issues (23.0%), post-concussive symptoms (12.9%), psychiatric symptoms (12.9%), military (15.8%), sex differences (2.5%), multiple concussions (2.5%), cultural or multicultural neuropsychology (2.2%), and older adults (1.3%).

Conclusions
Clinical neuropsychology research is proportionately over-focused on sports concussion to the exclusion of other causes of concussion. That said, sports concussion is easier to study than other causes of concussion and thus, this work has tremendous value for the field. Concussion research would best serve public health by focusing more on sex differences, multicultural issues, and other individual difference factors that alter risk for and recovery from concussion.
A-67 Examining Demographic Influence on Virtual Reality Cognitive Scores in Division I Collegiate Football Players
Authors: Wilkes J , Saliba S , Goldberg M , Griffith O , Slobounov S M 
Published: June 2023

Abstract

Purpose
The focus of our study was to understand the influence of demographics of collegiate football players on virtual reality (VR) cognitive scores over multiple seasons. We collected subject demographic factors and VR cognitive scores obtained at multiple time-points each year for four years. By observing multiple years of football athletes’ trends in scores through the seasons, we hope to better understand both how individualized factors and playing a collegiate collision sport affect cognition.

Methods
VR scores and demographic factors from 122 Division I football players through 2019-2022 seasons were analyzed. The VR is a fully immersive system, with separate modules to evaluate spatial memory, reaction time, and balance. Data collection occurred at pre-season, post-camp, mid-season, and post-season.

Results
Statistical analyses were conducted using SPSS v25. Participants were categorized by position, psychiatric disorder, concussion history, and year. Paired T-tests and one-way ANOVA were used to compare the scores of participants based on year and demographic factors. No demographic factors reached statistical significance, however VR balance scores were significantly lower in 2021 compared to other seasons (p&lt;.05). Spatial memory scores trended toward significance between individuals with and without concussion history (p=.064). VR balance scores were significantly lower in 2021 (p&lt;.001) across all time points.

Conclusions
While it was found that demographic factors did not influence VR performance, data suggests influence of concussion history on spatial memory warrants further investigation. The balance deficits in 2021 merit further exploration, but overall findings suggest participation in collegiate football without observable acute cognitive deficit.
A-69 The Impact of Sleep Disturbance on Depression and Anxiety Post-Concussion Among High School Athletes
Authors: Withers J , Stephenson K , Berkner P 
Published: June 2023

Abstract

Purpose
This study aims to explore the relationship between concussion-related sleep symptoms and affective symptoms in high school athlete.

Methods
A retrospective analysis of the Maine Concussion Management Initiative (MCMI) Immediate Post-concussion Assessment Tool ™ (ImPACT™) database was conducted to investigate the relationship between sleep and affective symptom scores in high school athletes (14-18 years) within 7 days of sustaining a concussion. The Post-Concussion Symptom Scale (PCSS) was completed by each athlete as part of their post-injury ImPACT™ testing battery. Sleep-related symptoms and affective/mood related symptoms from the PCSS were summed to create a sleep and affective symptom score, respectively.

Results
The final sample included 548 adolescents (M=15.94±1.06 years old; 50.4% female) were evaluated 3.16±1.85 days after injury. The results of a simple linear regression revealed a significant relationship between sleep and affective symptoms (F(1,546)=142.60, p&lt;.001), and the model explained 20.7% of the total variance of affective symptom scores. Additionally, there was an association between gender and affective symptoms (Χ2(1)=6.39, p=.01), with females 1.6 times more likely to report at least one affective symptom. Females (M=3.62±4.33) had significantly higher affective symptom scores compared to their male (M=2.35±3.46) counterparts (t(546)=3.79, p&lt;.001).

Conclusions
This study provides evidence of a significant relationship between sleep disturbance and affective symptoms in high school-aged athletes following concussion. Female athletes reported higher affective symptom scores.
Obesity causally influencing brain cortical structure: a Mendelian randomization study
Authors: Chen Wenhui , Feng Jia , Guo Jie , Dong Shiliang , Li Rufeng , NGO Jacky C K , Wang Cunchuan , Ma Yi , Dong Zhiyong 
Published: June 2023

Abstract
Obesity may lead to cognitive impairment and psychiatric disorders, which are associated with alterations in the brain cortical structure. However, the exact causality remains inconclusive. We aimed to conduct two-sample Mendelian randomization (MR) analysis to identify the causal associations of obesity [body mass index (BMI), waist-hip ratio (WHR), and waist-hip ratio adjusted for BMI ((WHRadjBMI)) and brain cortical structure (cortical thickness and cortical surface area). Inverse-variance weighted (IVW) method was used as the main analysis, whereas a series of sensitivity analyses were employed to assess heterogeneity and pleiotropy. The main MR results showed that higher BMI significantly increased the cortical surface area of the transverse temporal (β = 5.13 mm2, 95% confidence interval [CI]: 2.55–7.71, P = 9.9 × 10−5); higher WHR significantly decreased cortical surface area of the inferior temporal (β = −38.60, 95% CI: −56.67- -20.54, P = 1.2 × 10−5), but significantly increased cortical surface area of the isthmus cingulate (β = 14.25, 95% CI: 6.97–21.54, P = 1.2 × 10–4). No significant evidence of pleiotropy was found in the MR analyses. This study supports that obesity has a causal effect on the brain cortical structure. Further studies are warranted to understand the clinical outcomes caused by these effects.
EMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors
Authors: Fernández-Fernandez Beatriz , Sarafidis Pantelis , Soler Maria José , Ortiz Alberto 
Published: June 2023

ABSTRACT
In the EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin) trial, empagliflozin reduced cardiorenal outcomes by 28% (hazard ratio 0.72; 95% confidence interval 0.64–0.82; P &lt; .0001) in a diverse population of over 6000 chronic kidney disease (CKD) patients, of whom &gt;50% were not diabetic. It expanded the spectrum of CKD that may benefit from sodium-glucose cotransporter 2 (SGLT2) inhibition to participants with urinary albumin: creatinine ratio &lt;30 mg/g and estimated glomerular filtration rate (eGFR) &gt;20 mL/min/1.73 m2 or even lower (254 participants had an eGFR 15–20 mL/min/1.73 m2). EMPA-KIDNEY was stopped prematurely because of efficacy, thus limiting the ability to confirm benefit on the primary outcome in every pre-specified subgroup, especially in those with more slowly progressive CKD. However, data on chronic eGFR slopes were consistent with benefit at any eGFR or urinary albumin:creatinine ratio level potentially delaying kidney replacement therapy by 2–27 years, depending on baseline eGFR. The representation of diverse causes of CKD (&gt;1600 participants with glomerular disease, &gt;1400 with hypertensive kidney disease, &gt;450 with tubulointerstitial disease and &gt;600 with unknown cause) was higher than in prior SGLT2 inhibitor trials, although polycystic kidney disease was excluded. Around 15% (almost 1000) of participants were not on renin–angiotensin system blockade. The clinical characteristics of the cohort differed from DAPA-CKD (A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease), as did the frequency of individual components of the primary outcome in the placebo arm. Thus, rather than compare EMPA-KIDNEY with DAPA-CKD, the results of both trials should be seen as complementary to those of other SGLT2 inhibitor trials. Overall, EMPA-KIDNEY, a recent meta-analysis and post hoc analyses of participants with type 2 diabetes mellitus (T2DM) but no baseline CKD in other trials, indicates that SGLT2 inhibitor treatment will benefit an expanded CKD population with diverse baseline albuminuria or eGFR values, presence of T2DM or cause of CKD, as well as providing primary prevention of CKD in at least the T2DM setting.
Baseline proteinuria level and adverse outcomes in pregnant women with chronic kidney disease: new evidence and a note of caution
Authors: Kervella Delphine , Torreggiani Massimo 
Published: June 2023

ABSTRACT
About 3% of all pregnancies occur in patients with some degree of chronic kidney disease (CKD) and, in turn, CKD is a risk factor for developing hypertensive disorders of pregnancies (HDP) and unfavorable pregnancy outcomes, at both the maternal and fetal level. CKD is often characterized by proteinuria and proteinuria is a risk factor for HDP. However, even if the positive correlation between proteinuria and unfavorable pregnancy outcomes is well acknowledged, the degree of proteinuria associated with adverse outcomes is still a matter of debate. In this issue of the Journal, Li et al. present a retrospective study that shows that &gt;1 g of proteinuria/day is associated with worse maternal outcomes while &gt;2 g/day with worse fetal ones. This study gives proteinuria thresholds for unfavorable outcomes in pregnant CKD patients, but it should be kept in mind that there is a linear correlation between proteinuria and worse pregnancy outcomes, thus a strict surveillance during the entire gestation should be advised independently of the proteinuria level.
Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Authors: Ngo Linh , Lee Xiang Wen , Elwashahy Mohamed , Arumugam Pooja , Yang Ian A , Denman Russell , Haqqani Haris , Ranasinghe Isuru 
Published: June 2023

Abstract

Aims
Catheter ablation of atrial fibrillation (AF) is now a mainstream procedure although long-term outcomes are uncertain. We performed a systematic review and meta-analysis of procedural outcomes at 5 years and beyond.

Methods and results
We searched PubMed and Embase and after the screening, identified 73 studies (67 159 patients) reporting freedom from atrial arrhythmia, all-cause death, stroke, and major bleeding at ≥5 years after AF ablation. The pooled mean age was 59.7y, 71.5% male, 62.2% paroxysmal AF, and radiofrequency was used in 78.1% of studies. Pooled incidence of freedom from atrial arrhythmia at 5 years was 50.6% (95%CI 45.5–55.7%) after a single ablation and 69.7% [95%CI (confidence interval) 63.8–75.3%) after multiple procedures. The incidence was higher among patients with paroxysmal compared with non-paroxysmal AF after single (59.7% vs. 33.3%, p = 0.002) and multiple (80.8% vs. 60.6%, p &lt; 0.001) ablations but was comparable between radiofrequency and cryoablation. Pooled incidences of other outcomes were 6.0% (95%CI 3.2–9.7%) for death, 2.4% (95%CI 1.4–3.7%) for stroke, and 1.2% (95%CI 0.8–2.0%) for major bleeding at 5 years. Beyond 5 years, freedom from arrhythmia recurrence remained largely stable (52.3% and 64.7% after single and multiple procedures at 10 years), while the risk of stroke and bleeding increased over time.

Conclusion
Nearly 70% of patients having multiple ablations remained free from atrial arrhythmia at 5 years, with the incidence slightly decreasing beyond this period. Risk of death, stroke, and major bleeding at 5 years were low but increased over time, emphasizing the importance of long-term thromboembolism prevention and bleeding risk management.
From a to z and back again: motion and mobility in the fiction of John Muckle
Authors: Davidson Ian 
Published: June 2023

Abstract
The narrative fictions of John Muckle reflect the increased motion and mobility of people and things in the late twentieth and twenty-first centuries. This increase is a significant, although often invisible, part of the narrative and can be read through both the form and content of the writing. The working lives of his characters, and their sense of identity, are changed through acts of movement, while the objects that make up the environment they live in are similarly always in the process of change. Motion is not, however, the article claims, initiated or determined by social forces, or the inevitable consequence of a capitalist system that demands ever more productivity and growth. Motion is always and already there, and therefore is changed, but not initiated, by economic and social pressures. It is this interplay between people and things that are always and already moving, and a capitalism that seeks to change or direct that movement, that provides the tensions within the narrative and the events in the lives of the characters, both tragic and joyful. Narratives, and the movements they often describe, become less about beginnings and endings, and more about sequences of collisions and moments of change in direction and velocity.
Quantitative analysis reveals influencing factors to facilitate successful anodal-ring capture in left bundle branch pacing
Authors: Lu Wenzhao , Lin Jinxuan , Li Yao , Hu Qingyun , Cheng Chendi , Chen Ruohan , Dai Yan , Chen Keping , Zhang Shu 
Published: June 2023

AbstractAimsLeft bundle branch pacing (LBBP) maintains left ventricular synchrony but induces right ventricular conduction delay (RVCD). Although anodal-ring capture (ARC) during bipolar LBBP improves RVCD, it is not achieved in all patients receiving LBBP. This study aimed to analyze the factors influencing ARC implementation.Methods and resultsPatients receiving LBBP with intraoperative ARC testing were enrolled. Electrocardiographic parameters were measured, including stimulus-to-QRS duration (stim-QRSd), stimulus-to-left/right ventricular activation time (stim-LVAT/RVAT), and V6-V1 interpeak interval. The distribution of lead-tip sites was described as the corrected longitudinal and lateral distance (longit-/lat-dist). Relative angles of the LBBP lead were measured. Echocardiography in short-axis view was used to measure the intraseptal lead length. Intergroup comparisons, correlation analysis, and stepwise logistic regression were performed. In total, 105 patients were included, among which 65 (62%) patients achieved ARC at a pacing output ≤ 5.0 V/0.5 ms (average 3.1 V/0.5 ms). Anodal-ring capture further shortened the stim-QRSd by 13.1 ± 7.5 ms. Better unipolar-ring (cathodal) threshold and R-wave sensing in LBBP-ARC group indicated the critical role of ring–septum contact in ARC. Longer corrected longit-dist and shorter corrected lat-dist of lead-tip sites were positively correlated with higher success likelihood of ARC, likely due to the greater relative angle in which the lead enters the septum and consequently the longer intraseptal lead length and better ring–septum contact.ConclusionThis study elucidated the factors affecting the success likelihood of LBBP-ARC. These findings improve the understanding of LBBP-ARC, providing references for future research and clinical practice.