bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimum Clinically Important Difference in Patients Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion
Authors: Nie James W. , Hartman Timothy J. , MacGregor Keith R. , Oyetayo Omolabake O. , Zheng Eileen , Singh Kern 
Published: January 2023

BACKGROUND:
Few studies have established the minimum clinically important difference (MCID) in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for physical function and pain.

OBJECTIVE:
To establish MCID for physical function and pain patient-reported outcome measures (PROMs) for MIS-TLIF through anchor- and distribution-based methods using the Oswestry Disability Index (ODI) as the anchor.

METHODS:
Ninety-eight patients undergoing primary MIS-TLIF with preoperative and 1-year postoperative ODI scores were identified. MCID was calculated using anchor- and distribution-based methods. ODI responders were classified as patients who decreased by 1 disability classification. PROMs of Patient-Reported Outcome Measurement Information System-Physical Function (PROMIS-PF), 12-Item Short Form Physical Component Score (SF-12 PCS), Visual Analog Scale (VAS) back/leg, and ODI were collected preoperatively and 1-year postoperatively. Anchor-based methods were average change, minimum detectable change, change difference, receiver operating characteristic curve, and cross-sectional analysis. Distribution-based methods were standard error of measurement, receiver change index, effect size, and 0.5 ∗ ΔSD.

RESULTS:
Anchor-based methods ranged from 4.2 to 11.9 for PROMIS-PF, 6.0 to 15.8 for SF-12 PCS, 1.8 to 4.6 for VAS back, and 2.1 to 4.0 for VAS leg. The area under the curve for receiver operating characteristic analysis ranged from 0.66 to 0.81. Distribution-based methods ranged from 1.1 to 3.9 for PROMIS-PF, 1.6 to 10.4 for SF-12 PCS, 0.5 to 1.6 for VAS back, and 0.6 to 1.8 for VAS leg.

CONCLUSION:
Patients undergoing MIS-TLIF had a wide range of MCID values. The receiver operating characteristic curve was selected as the most clinically appropriate method. The corresponding MCID values were 4.2 for PROMIS-PF, 6.8 for SF-12 PCS, 1.8 for VAS back, and 2.4 for VAS leg.
On the Value of Dynamism in Transit Networks
Authors: Martínez Mori J. Carlos , Speranza M. Grazia , Samaranayake Samitha 
Published: January 2023

The rise of on-demand mobility technologies over the past decade has sparked interest in the integration of traditional transit and on-demand systems. One of the main reasons behind this is the potential to address a fundamental trade-off in transit: the ridership versus coverage dilemma. However, unlike purely fixed systems or purely on-demand systems, integrated systems are not well understood; their planning and operational problems are significantly more challenging, and their broader implications are the source of a heated debate. Motivated by this debate, we introduce the dynamicity gap, a general concept that quantifies the attainable benefit of allowing (but not requiring) dynamic components in the response strategy to a multistage optimization problem. Although computing the dynamicity gap exactly may be intractable, we develop an analytical framework with which to approximate it as a function of problem input parameters. The framework allows us to certify the value of dynamism (i.e., a dynamicity gap greater than one) for certain combinations of problem input parameters. We showcase our approach with two sets of computational experiments, from which we gain both qualitative and quantitative insights about the settings in which the integration of transit and on-demand systems may certifiably be a worthwhile investment.Funding: This work was partially supported by the National Science Foundation [Grants DMS-1839346 and CNS-1952011]. Part of this research was performed while the authors were visiting the Institute for Pure and Applied Mathematics, which is supported by the National Science Foundation [Grant DMS-1925919].Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.1193 .
Positioning play
Authors: Grimmer Tamsin 
Published: January 2023

Have you ever re-stacked the dishwasher after someone else helped you to load it? The position of objects is very important at times and even adults may become obsessed with putting things in order or straightening a picture on the wall. The latest article in this series explores this in more detail. Positioning–children show an interest in where things are, positioning items in lines, rows or by size. They may be fascinated with different types of lines (vertical or horizontal) or walk around sand tray edges or balance on walls. Some children may even prefer certain foods not to touch other foods or may be interested in the position of their bodies by lying on floors or under tables.
Effects of dispersion and pumping scheme on soliton-comb regimes in χ
(2) microresonators
Authors: Smirnov S. , Podivilov E. , Sturman B. 
Published: January 2023

Monochromatic pumping of

χ

(
2
)

microresonators is promising for frequency comb generation. Two main generation schemes refer to pumping into the phase-matched first harmonic (FH) and second harmonic (SH)—FH and SH pumping. The phase matching can be natural or artificial (employing periodic poling). Also, minimization of the FH and SH group velocity difference (temporal walk-off) is needed for effective comb generation. So far, perspective soliton-comb regimes were predicted for SH pumping in lithium niobate (LN)-based resonators at a special poling. Here we explore, analytically and numerically, the possibilities for realizing the

χ

(
2
)

comb generation for the remaining options of pumping as applied to LN microresonators. This includes the FH pumping case for the pump wavelength

λ
p

≃
2698

n
m

in radially poled resonators and also FH and SH pumping schemes at natural phase matching,

λ
p

≃
1664

and 832 nm. It is found that the nonlinear regimes are substantially different and less efficient here as compared to the primary SH pumping case. This is caused by a profound difference between the FH and SH excitation schemes and also by different combinations of signs of the dispersion coefficients for FH and SH resonator modes.
Predictive value of hemogram parameters in malignant transformation of the endometrium in patients with different risk factors
Authors: Firat Aysun , Ercan Aysegul , Mordeniz Cengiz , Verit Atmaca Fatma Ferda 
Published: January 2023

Objectives
To investigate whether the pretreatment hemogram parameters and their ratios can be used in predicting the endometrial transformation in patients with abnormal uterine bleeding.

Material and methods
Records of all patients who underwent an endometrial histopathological evaluation between 2011 and 2021 were investigated. Hemogram, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were analyzed. Chi square and Mann Whitney U tests were used for analysis. P<0.05 was considered statistically significant.

Results
427 patients were included, of whom 117 were presented with endometrial hyperplasia without atypia (27.4%; mean age, 42±9.7; Group II), 70 with atypia (16.3%; mean age, 53.4±9; Group III), 102 with early endometrial cancer (EC) (23.8%; mean age, 63±7.8; Group IV) and 38 with advanced disease (8.8%; mean age, 63.3±10.5; Group V). Patients without pathology constituted the control group (23.4%; mean age, 42.2±9.5; Group I). Risk factors for atypia and carcinoma were determined as age, postmenopausal state, obesity, diabetes, and increased estrogen exposure (each, p<0.05). There was no significant difference in NLR and PLR (p>0.05). However, hemoglobin and hematocrit levels were higher in Groups IV and V (13.9 vs 13.1 mg/dL, and 39.1 vs 38.8%, respectively; p<0.01). Platelet value was significantly higher in Groups III to V (282x109/L, 283x109/L and 295x109/L; p<0.05, p<0.05 and p<0.01, respectively).

Conclusions
Our findings support the impact of inflammation on malign transformation from normal endometrial mucosa to atypia and carcinoma. NLR and PLR values showed no statistical difference. Instead, thrombocytosis may have a predictive role in EC.
Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn's Disease: A Post Hoc Analysis of the REACH Trial
Authors: Cheifetz Adam S. , Vande Casteele Niels , Wang Zhongya , Dubinsky Marla C. , Papamichael Konstantinos 
Published: January 2023

INTRODUCTION:
Exposure-outcome relationship data show that higher infliximab concentrations are associated with better outcomes in patients with Crohn's disease (CD). However, most of these data were derived from adult patients on maintenance therapy. We aimed to investigate the association of infliximab concentrations during and early after induction therapy of infliximab with short-term and long-term clinical outcomes in a pediatric CD population.

METHODS:
We conducted a post hoc analysis of the REACH trial which included pediatric patients with moderate-to-severe CD treated with infliximab (n = 103). The investigated outcomes were early clinical remission (CR) defined as a pediatric CD activity index score of ≤ 10, assessed at week 10, and long-term clinical response (LTCR) defined as a decrease from baseline in the pediatric CD activity index score of at least 15 points, with a total score of ≤ 30 and no need for drug discontinuation, assessed at weeks 30 and 54.

RESULTS:
Based on multivariable logistic regression analysis, higher week 10 infliximab concentrations were independently associated with CR at week 10 (odds ratio: 1.54; 95% confidence interval: 1.06–2.22; P = 0.022) and LTCR at week 30 (odds ratio: 1.62; 95% confidence interval: 1.12–2.36; P = 0.010). Receiver operating characteristic analysis identified week 10 infliximab concentration thresholds of ≥7.1 μg/mL and ≥6.5 μg/mL to be associated with CR at week 10 and LTCR at week 30, respectively.

DISCUSSION:
Higher postinduction infliximab concentrations are associated with both short-term and long-term favorable clinical outcomes in pediatric patients with CD. Tailoring dosing during induction to achieve higher infliximab exposure may lead to better outcomes in pediatric patients with CD.
A systematic review of meta-analyses in second language research: current practices, issues, and recommendations
Authors: Vuogan Alyssa , Li Shaofeng 
Published: January 2023

Abstract
This study provides a systematic review of the methodological features of meta-analyses in second language learning. The synthesis aims to inform how meta-analyses in L2 learning have been conducted, evaluate whether methodological decisions are aligned with norms and standards, identify issues, and suggest solutions based on expert advice, statistical guides, and best practices. A total of 120 meta-analyses were retrieved and coded for key features related to bibliographic and demographic characteristics, search and selection, publication bias, quality control, data coding, data analysis, and effect size interpretation. The synthesis showed that 98 meta-analyses examined the effectiveness of instructional treatments, 21 investigated correlations, and one explored the occurrence of events. These meta-analyses included an average of 37 primary studies (range = 9–302). Common selection criteria the meta-analyses applied included publication type, availability of data for effect size calculation, learner traits, learners’ target languages, publication dates, publication language, independent variables, and dependent variables. Major strategies used to detect publication bias included creating a funnel plot, using trim-and-fill analysis, and calculating a fail-safe N. Typical moderators examined in the meta-analyses related to research context, treatment features, sample characteristics, and outcome measures. The synthesis also identified a number of issues, including failure to report key features such as model selection (fixed- vs. random-effects model), effect size weighting, and so on; conducting moderator analysis based on very small cell sizes (e.g., only one study in a subgroup); lack of justification for certain methodological decisions such as using d instead of g, using confidence intervals rather than Q-tests to identify significant moderators; lack of quality control; and confounding study-based and synthesis-based moderators. We offer advice on identified issues and call for more transparency of reporting.
NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells
Authors: Noguera Hurtado Héctor , Gresch Anne , Düfer Martina 
Published: January 2023

Abstract
Due to its unique features amongst ionotropic glutamate receptors, the NMDA receptor is of special interest in the physiological context but even more as a drug target. In the pathophysiology of metabolic disorders, particularly type 2 diabetes mellitus, there is evidence that NMDA receptor activation contributes to disease progression by impairing beta cell function. Consequently, channel inhibitors are suggested for treatment, but up to now there are many unanswered questions about the signaling pathways NMDA receptors are interfering with in the islets of Langerhans. In this review we give an overview about channel structure and function with special regard to the pancreatic beta cells and the regulation of insulin secretion. We sum up which signaling pathways from brain research have already been transferred to the beta cell, and what still needs to be proven. The main focus is on the relationship between an over-stimulated NMDA receptor and the production of reactive oxygen species, the amount of which is crucial for beta cell function. Finally, pilot studies using NMDA receptor blockers to protect the islet from dysfunction are reviewed and future perspectives for the use of such compounds in the context of impaired glucose homeostasis are discussed.
Machine learning-based prediction of total phenolic and flavonoid in horticultural products
Authors: Kusumiyati Kusumiyati , Asikin Yonathan 
Published: January 2023

Abstract
The purpose of this study was to predict the total phenolic content (TPC) and total flavonoid content (TFC) in several horticultural commodities using near-infrared spectroscopy (NIRS) combined with machine learning. Although models are typically developed for a single product, expanding the coverage of the model can improve efficiency. In this study, 700 samples were used, including varieties of shallot, cayenne pepper, and red chili. The results showed that the TPC model developed yielded R
2cal, root mean squares error in the calibration set, R
2pred, root mean squares error in prediction set, and ratio of performance to deviation values of 0.79, 123.33, 0.78, 124.20, and 2.13, respectively. Meanwhile, the TFC model produced values of 0.71, 44.52, 0.72, 42.10, and 1.87, respectively. The wavelengths 912, 939, and 942 nm are closely related to phenolic compounds and flavonoids. The accuracy of the model in this study produced satisfactory results. Therefore, the application of NIRS and machine learning to horticultural products has a high potential of replacing conventional laboratory analysis TPC and TFC.
General three-dimensional equilibrium for stationary inviscid fluids in the presence of a gravitational potential
Authors: Hussain Eman T. , Ibrahim Doaa A. , El-Kalaawy Omar H. , Moawad Salah M. 
Published: January 2023

Abstract
In this paper, we study the properties of the general three-dimensional equilibrium solutions for steady-state equations of inviscid fluids. Incompressible, homogeneous, inhomogeneous and compressible flows motion in a gravitational potential are considered. General three-dimensional formulas for the gas pressure and the gravitational potential are obtained. For incompressible flows, the vector and scalar potentials of the velocity field are used to derive general formulas for general three-dimensional solutions. To verify our results, some examples are presented. For compressible flows, a class of three-dimensional solutions is constructed.
Enhancing Tensile Response of Polymeric Elements Using Bioinspired 3D Printing: Studying the Effects of Printing Patterns and Process Parameters
Authors: Namakiaraghi Parsa , McNally Liam , Spragg Robert , Farnam Yaghoob Amir 
Published: January 2023

Abstract
In construction, additive manufacturing (AM) can be used to create structural or non-structural elements, such as frameworks, reinforcement, or panels. However, AM technology still requires enhancements for the mechanical response of final 3D printed elements to accommodate the mechanical needs of structural components. This paper evaluates various AM process parameters and bioinspired printing patterns to improve the mechanical performance of 3D printed polymeric elements. AM processes, including printing speed and nozzle diameter, are studied. Bioinspired patterns, including Bouligand-like, alternating, sinusoidal, grid, triangular, and hexagonal, are investigated and compared to simple parallel patterns. Results of this study suggest that the mechanical behavior of 3D printed elements can be significantly enhanced by optimizing the printing speed and nozzle diameter. Incorporating bioinspired architectures in AM, such as the Bouligand pattern, are shown to enhance mechanical performance. Slower speeds and larger nozzle diameters result in higher tensile strength. Continuous and twisting patterns yield more ductility, while patterns parallel to the direction of the tensile test result in higher strengths. Microscopic images from the fracture surface indicate that a larger nozzle diameter enhances intra- and interlayer bonding between consequent printed layers. Additionally, more complex crack propagation is observed in twisting patterns with enhanced elongation before total failure. It is also observed that there is an optimal time of exposure to high temperature for deposited materials during AM to improve bonding between adjacent beads. Bioinspired patterns help maintain higher ductility with similar strength despite encompassing higher porosity than parallel patterns, which could be advantageous for material optimization purposes. The bioinspired 3D printed polymeric elements showed tensile properties higher than those of plain polymer filament. The outcome of this study can help optimize both the process and the architecture of 3D printed elements to enhance their mechanical properties to be used as reinforcing elements for reinforced concrete applications.
Forest Fire and Environmental Damage: The Indonesian Legal Policy and Law Enforcement
Authors: Wijayanto Adi , Wiraraja Hatta Acarya , Idris Siti Aminah 
Published: January 2023

Law enforcement regarding the environment is in fact a responsibility that should be fulfilled by the state. In this case, the state is the main actor in prevention, as well as a protector from any efforts to destroy nature and the environment. It can be understood that to maintain the crucial elements in the existence of a state, as agreed in the Montevideo Convention, among others, permanent residents, definite territory, government, the ability to enter into relations with the state. other. So with this it can be understood that environmental damage due to forest fires, is a form of threat also in the area element, because by burning ecosystems, it will result in an imbalance of life in an area, it can also be interpreted if the impacts arising from forest fires spread to enter the area. on the territory of neighboring countries, it will lead to unfavorable relations with other countries.
A rare case of severe bilateral Graves’ orbitopathy involving an anophthalmic socket
Authors: Ali Mudassir , Abouzaid Mona , Clarke Lucy , Lau Gordon , Mitchell Anna , Napier Catherine , Pearce Simon 
Published: January 2023

Summary
This is a report of a rare case of Graves’ hyperthyroidism associated with severe bilateral Graves’ orbitopathy, in a patient with an anophthalmic eye socket. On clinical review her prosthetic eye (left eye) was tilting upwards, along with worsening of Graves’ orbitopathy (GO) in the only seeing eye. As she refused IV glucocorticoids, she was offered rituximab which only caused a transient improvement in the clinical activity score of the eye. She had persistent right upper lid retraction of 6 mm, associated with lagophthalmos. To protect her seeing eye from corneal ulceration, the patient received a botulinum toxin injection to the right upper eyelid to induce blepharoptosis as an interim measure prior to right upper eyelid blepharotomy in April 2021. This patient remains biochemically euthyroid on block and replace therapy and her TRAb level is falling over time. Treatment for active GO is ongoing and the patient required a redo blepharotomy for painful corneal exposure in the right eye.

Learning points

Graves’ orbitopathy (GO) does not actually primarily affect the eyeball itself but the orbital contents as well.

Patients with severe GO in an only seeing-eyed patient should be referred early to a multidisciplinary Joint Thyroid Eye clinic for expert review and management.

Patient outcomes including sight loss are likely to be improved by the extended range of medical and surgical treatment modalities available at specialist clinics treating GO, including the use of immunomodulatory drugs like rituximab or teprotumumab.
Bal felső lebenyi adenocarcinoma és pulmonális vénás fejlődési rendellenesség együttes előfordulása
Authors: Kovács Ottó , Szántó Zoltán , Vida Gábor , Juhász Árpád 
Published: January 2023

Összefoglaló.
Esetismertetés: 60 éves férfibeteg esete kerül bemutatásra
jelen közleményben. Operábilis bal felső lebenyi tüdő adenocarcinomája a lebeny
rendellenes véna pulmonalis beömlésével (partial anomalous pulmonary venous
connection – PAPVC) szövődött. Az aortaív felett a hemiazygos vénába ömlő véna
pulmonalis superior a bal véna brachiocephalicába vezette a bal felső lebeny
vénás vérét, bal jobb shunt-öt okozva ezzel. A fejlődési rendellenességet
egyértelműen csak a műtét során sikerült azonosítani. Az elvégzett bal felső
lobektómia mindkét elváltozás definitív megoldását jelentette.
Megbeszélés: Jelen közleményünkkel együtt a fellelhető
szakirodalomban (PubMed) 32 esetleírás szerepel erről a ritka fejlődési
anomáliáról. Ez aláhúzza a preoperatív computer tomográfia (CT) jelentőségét és
a mellkassebész szerepét a CT felvételek értékelésében.
Summary. Authors present a case of a 60-year-old male patient with
left upper lobe cancer in association with partial anomalous pulmonary venous
connection (PAPVC) in the same lobe. The hemiazygous vein joined the left
superior pulmonary vein above the aorta in the thorax cavity draining into the
left brachiocephalic vein causing left to right shunt flow. PAPVC was clearly
identified intraoperatively and left upper lobectomy was performed as definitive
solution for both. PAPVC was closed by stapler. To our knowledge 32 operated
cases of lung cancer with PAPVC has been described in the literature (PubMed),
including our patient.