bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of the therapeutic effect of auricular bean pressing on early knee osteoarthritis pain: A randomized controlled trial
Authors: Lin Yeyan , Wu Yongqin , Zhou Xuelai , Shen Bin , Lv Cunxian 
Published: March 2023

BACKGROUND: In the treatment of knee osteoarthritis (KOA), there is a need for the long-term use of therapeutic drugs that reduce joint pain and have fewer adverse effects. OBJECTIVE: This study aimed to investigate the therapeutic effect of bean pressing on ear points on early KOA pain. METHODS: One hundred patients with KOA recruited at the Wenzhou Hospital of Traditional Chinese Medicine between February 2019 and May 2022 were divided randomly into a treatment group (n= 50) and control group (n= 50). Patients in the treatment group received regular rehabilitation combined with auricular bean-pressing treatment, while patients in the control group only received conventional rehabilitation treatment. The measurement indicators – knee swelling, tenderness, range of motion sign score, C-reactive protein, and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) indexes – were recorded before and after treatment. RESULTS: On day 5 following the start of treatment, the visual analog scale (VAS) and WOMAC scores of the treatment group were significantly lower than those of the control group (P< 0.05), and the VAS and WOMAC scores in the treatment group after treatment were significantly lower than those before treatment (P< 0.05). At week 4 after the start of treatment, the dosage of nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment group was significantly lower than that in the control group (P < 0.05). No adverse events were observed during the treatment. CONCLUSIONS: Auricular bean-pressing therapy had an analgesic effect and could also alleviate mild to moderate KOA swelling, joint stiffness, and other symptoms, effectively reducing the demand for NSAIDs and improving both knee function and quality of life. The results suggested that auricular bean-pressing therapy has promising prospects in the treatment of early KOA pain.
Time-optimized sequential decision making for service management in smart city environments
Authors: ALFahad Saleh , Anagnostopoulos Christos , Kolomvatsos Kostas 
Published: March 2023

Edge Computing is a new computing paradigm that aims to enhance the Quality of Service (QoS) of applications running close to end users. However, edge nodes can only host a subset of all the available services and collected data due to their limited storage and processing capacity. As a result, the management of edge nodes faces multiple challenges. One significant challenge is the management of the services present at the edge nodes especially when the demand for them may change over time. The execution of services is requested by incoming tasks, however, services may be absent on an edge node, which is not so rare in real edge environments, e.g., in a smart cities setting. Therefore, edge nodes should deal with the timely and wisely decision on whether to perform a service replication (pull-action) or tasks offloading (push-action) to peer nodes when the requested services are not locally present. In this paper, we address this decision-making challenge by introducing an intelligent mechanism formulated upon the principles of optimal stopping theory and applying our time-optimized scheme in different scenarios of services management. A performance evaluation that includes two different models and a comparative assessment that includes one model are provided found in the respective literature to expose the behavior and the advantages of our approach which is the OST. Our methodology (OST) showcases the achieved optimized decisions given specific objective functions over services demand as demonstrated by our experimental results.
ERIC GUTSTEIN E A LEITURA E ESCRITA DO MUNDO COM A MATEMÁTICA
Authors: Moura Amanda Queiroz , Faustino Ana Carolina 
Published: March 2023

Eric Gutstein, ou Rico Gutstein como prefere ser chamado, nasceu em Nova York nos Estados Unidos, e é uma referência internacional, na perspectiva da Educação Matemática Crítica. Ele tem atuado, tanto na escola básica como na universidade, para que a matemáticacontribua para a construção de uma sociedade mais justa. É professor do Departamento de Curriculum e Instrução da Universidade de Illinois, em Chicago e tem ensinado e pesquisadosobre ensinar e aprender matemática para justiça social, alfabetização crítica em um contexto urbano e multicultural, bem como, abordagens freirianas de ensino e de aprendizagem e apolítica escolar de Chicago.
USO DO MIP COMO ESTRATÉGIA DE REDUÇÃO DE CUSTOS NA PRODUÇÃO DE SOJA NO ESTADO DO PARANÁ
Authors: Staback Daiane , Blanck Priscila Laís , Mariussi Vanderlei , Galante Valdir Antonio 
Published: March 2023

Pretendeu-se com este estudo comparar os custos de produção da soja convencional í quela com o monitoramento integrado de pragas – MIP- para as safras 2013/2014 a 2017/2018. O uso do MIP constitui ferramenta útil à atividade agrí­cola por viabilizar menores custos de produção sem afetar a produção, com ação corretiva apenas em caso de dano econômico, com redução de riscos às pessoas e ao ambiente. Os resultados demonstram volume de produção ligeiramente acima do sistema convencional, enquanto o número médio de aplicação de inseticidas, bem como o custo destas aplicações, oscila na casa de 50% das necessárias no sistema convencional no perí­odo. Do mesmo modo, um menor número de aplicações também significa que o produtor assume menor risco de intoxicação ou acidentes de trabalho pelo sistema MIP, assim como menor risco ao ambiente.
Green biosynthesis of rare DHA-phospholipids by lipase-catalyzed transesterification with edible algal oil in solvent-free system and catalytic mechanism study
Authors: Zhang Tiantian , Li Binglin , Wang Zhulin , Hu Dan , Zhang Xiaoli , Zhao Binxia , Wang Jiao 
Published: March 2023

Docosahexaenoic acid (DHA)-enriched phosphatidylcholine (PC) has received significant scientific attention due to the health benefits in food and pharmaceutical products. In this work, the edible algal oil rich in DHA-triacylglycerol (DHA-TAG) without pretreatment was first used as the DHA donor for the transesterification of phospholipids (PLs) to prepare three kinds of rare PLs, including DHA-PC, DHA-phosphatidylethanolamine (DHA-PE), and DHA-phosphatidylserine (DHA-PS). Here, 153 protein structures of triacylglycerol lipase (EC 3.1.1.3) were virtually screened and evaluated by transesterification. PLA1 was the best candidate due to a higher DHA incorporation. Results showed that the transesterification of PC with DHA-TAG at 45°C and 0.7% water content (without additional water addition) could produce DHA-PC with 39.1% DHA incorporation at 30 min. The different DHA donors, including forms of fatty acid, methyl ester, and triglycerides, were compared. Molecular dynamics (MD) was used to illustrate the catalytic mechanism at the molecular level containing the diffusions of substrates, the structure-activity relationship of PLA1, and the effect of water content.
Serum HBsAg and HBcrAg is associated with inflammation in HBeAg-positive chronic hepatitis B patients
Authors: Zhao Jing , Bian Dandan , Liao Hao , Wang Yang , Ren Yan , Jiang Yingying , Liu Shuang , Chen Xinyue , Hu Zhongjie , Duan Zhongping , Lu Fengmin , Zheng Sujun 
Published: March 2023

Backgrounds &amp; aimsLiver inflammation is the main risk factor for developing liver fibrosis, cirrhosis, and even hepatocellular carcinoma in chronic hepatitis B (CHB) patients. To replace biopsy, additional non-invasive biomarkers to diagnose and grade liver necroinflammation are urgently required in clinical practice.MethodNinety-four CHB patients, including 74 HBeAg-positive and 20 HBeAg-negative patients, were enrolled and started entecavir or adefovir therapy. Serum HBV RNA, HBV DNA, HBsAg, hepatitis B core-related antigen (HBcrAg), ALT and AST levels, as well as intrahepatic HBV DNA and cccDNA were measured at baseline and during treatment. Liver inflammation was assessed at baseline and month 60 by liver biopsy. Inflammation regression was defined as a ≥1-grade decrease according to the Scheuer scoring system.ResultsIn HBeAg-positive CHB patients, at baseline, serum HBsAg and HBcrAg levels negatively correlated with inflammation grade, while ALT and AST levels positively correlated with inflammation grade. AST plus HBsAg exhibited excellent diagnostic ability for significant inflammation with an AUROC of 0.896. After 60 months of antiviral treatment, almost all the patients’ liver inflammation ameliorated to G1, and no patients had inflammation progression.ConclusionBesides ALT and AST, serum HBsAg and HBcrAg correlated with inflammation grade in HBeAg-positive CHB patients before NAs treatment. Moreover, the combination of HBsAg and AST exhibited excellent diagnostic ability for significant inflammation.
European dietitians as key agents of the green transition: An exploratory study of their knowledge, attitudes, practices, and training
Authors: Muñoz-Martínez Júlia , Carrillo-Álvarez Elena , Janiszewska Katarzyna 
Published: March 2023

IntroductionHow food systems are currently provisioning food to the population is a matter of debate worldwide. Food systems, driven by widespread and increasing adherence to a westernized dietary pattern, are failing to meet people’s basic needs and are draining natural resources. There is a push to make food systems more healthy, fair, and sustainable. To this end, action from all players is needed to meet the international agenda. In this regard, dietitians play a crucial role, as they can provide advice and promote actions that foster the adoption of more sustainable dietary patterns (SDP) as well as the promotion of sustainable food systems. As an emerging requirement in their training, it is crucial to know what dietitians know about SDP as well as their attitudes and current practices in this field in order to strengthen their competences and be key agents for the green transition. For this reason, the aim of the present study is to explore the knowledge, attitudes, practices, and training (KAPT) of European dietitians on SDP by administering an online survey.MethodsCross-sectional survey administered between April-August 2021 to dietitians based in the European countries with National Dietetic Associations or Education Associate Members affiliated to the European Federation of Associations of Dietitians (EFAD). Results were analyzed based on European region of professional practice (Northern/Southern/Western/South-East Europe), area of expertise and years of experience.ResultsResponses from 2211 dietitians from 25 countries were received, although the analysis was based on those that responded at least 90% of the survey (n=208). European dietitians are lacking training on SDP but are willing to learn more about it. Most dietitians perceive themselves as able to define an SDP, although aspects concerning social and economic sustainability were underestimated. Dietitians concur that barriers exist to the promotion of SDP, such as the lack of updated national food-based dietary guidelines and the absence of support from peers and managers. The country of professional activity seemed to be key to influencing dietitians’ KAPT.DiscussionThese results emphasize the need to strengthen European dietitians’ training in SDP and increase public/private commitment to consider dietitians as key professionals for the transition towards SDP.
Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
Authors: Cairns Jonathan , Leonard Emilyanne , Khan Kainat , Parks Conor , Maglennon Gareth , Zhang Bairu , Lazic Stanley E. , Ewart Lorna , David Rhiannon 
Published: March 2023

Introduction: Microphysiological systems (MPS; organ-on-a-chip) aim to recapitulate the 3D organ microenvironment and improve clinical predictivity relative to previous approaches. Though MPS studies provide great promise to explore treatment options in a multifactorial manner, they are often very complex. It is therefore important to assess and manage technical confounding factors, to maximise power, efficiency and scalability.Methods: As an illustration of how MPS studies can benefit from a systematic evaluation of confounders, we developed an experimental design approach for a bone marrow (BM) MPS and tested it for a specified context of use, the assessment of lineage-specific toxicity.Results: We demonstrated the accuracy of our multicolour flow cytometry set-up to determine cell type and maturity, and the viability of a “repeated measures” design where we sample from chips repeatedly for increased scalability and robustness. Importantly, we demonstrated an optimal way to arrange technical confounders. Accounting for these confounders in a mixed-model analysis pipeline increased power, which meant that the expected lineage-specific toxicities following treatment with olaparib or carboplatin were detected earlier and at lower doses. Furthermore, we performed a sample size analysis to estimate the appropriate number of replicates required for different effect sizes. This experimental design-based approach will generalise to other MPS set-ups.Discussion: This design of experiments approach has established a groundwork for a reliable and reproducible in vitro analysis of BM toxicity in a MPS, and the lineage-specific toxicity data demonstrate the utility of this model for BM toxicity assessment. Toxicity data demonstrate the utility of this model for BM toxicity assessment.
A comparison of physiological intensity and psychological perceptions during three different group exercise formats
Authors: Gottschall Jinger S. , Hastings Bryce 
Published: March 2023

IntroductionPast research highlighted that group fitness is an ideal format to meet exercise prescription guidelines. To add, a group enhances exertion, enjoyment, and satisfaction. In the last five years, streaming (live classes on screen with other participants visible) and on demand (pre-recorded classes on screen without other participants visible) formats have grown in popularity. Our goal is to compare the physiological intensity and psychological perceptions of live group, live streaming, and non-live on demand classes. We hypothesize that live classes will have the greatest cardiovascular intensity, enjoyment, and satisfaction followed by streaming and finally on demand.MethodsFifty-four adults between 18–63 years, who regularly participate in group fitness classes, recorded their heart rate with a chest transmitter during a mixed-martial arts cardiovascular class on consecutive weeks in random order. We calculated the mean, identified the max, and extracted the top 300 values (5 min) for comparison between conditions.ResultsFollowing each class, the participants completed an online survey to evaluate their rate of perceived exertion, enjoyment, and satisfaction. Confirming our hypothesis, mean class heart rate and mean heart rate for the five minutes at the highest intensity were 9% greater during the live group format compared to both live streaming and non-live on demand (all values, p &lt; 0.01). However, there was no difference in any heart rate variables between the streaming and on demand formats. Also, rate of perceived exertion, enjoyment, and satisfaction were all significantly greater during the live session compared to the home collections (all values, p &lt; 0.05).DiscussionStreaming and on demand group fitness formats are viable options for meeting exercise prescription guidelines. But physiological intensity and psychological perceptions were greater during the live class format.
Severinia buxifolia Leaves: Isolation, Characterization of Major Metabolites from the Bioactive Fractions and their Antiprotozoal Activity
Authors: Nour Safaa , Salama Maha , Mahrous Engy , El-Askary Hesham , Hifnawy Mohamed , Abdel Kawy Mustafa A. 
Published: March 2023

In an effort to explore herbal drugs as treatment for some neglected tropical diseases (NTDs), Severinia buxifolia (Poir) Ten, was selected and investigated for its antiprotozoal activity. Based on this objective, the ethyl acetate (EA), n-hexane (HE), methylene chloride (MC), n-butanol (BU) fractions of the leaves of S. buxifolia were screened for the in vitro antiprotozoal activity against Plasmodium falciparum, Trypanosoma brucei, Trypanosoma cruzi and Leishmania infantum. Hexane and MC fractions showed good antiprozoal activity (IC50 for HE8.56, 8.64, 3.37, 10.26 µg/mL and MC 8.20, 12.7, 32.69, 2.63 µg/mL) against T. cruzi, L. infantum,T. brucei,and P. falciparum respectively. However, the EA and BU were inactive. Accordingly, two major compounds were isolated from HE identified as and friedelin (1) and β-sitosterol (2) while two coumarins were isolated from MC and identified as seselin (3) and (+)-ulopterol (4). Identification of the compounds was carried out based on mass spectrometry, proton and carbon 1D NMR, as well as 1H-13C HSQC and HMBC spectral analysis. Among isolated compounds, only seselin showed antiprotozoal activity with IC50 of 38.47 and 38.5 mg/mL against T. cruzi and P. falciparum, respectively and no cytotoxicity. Furthermore, an HPLC fingerprint for each fraction was achieved with the aim of authenticating the plant chemical profile and identified seslin and ulopterol as major constituents of the plant extract.
Fach- und sprachintegriertes Lernen auf Deutsch (CLILiG)
Authors: Haataja Kim , Wicke Rainer E. 
Published: March 2023

Ein gutes Jahrzehnt nach dem Beginn einer mehr systematischen Beschäftigung mit dem fach- und sprachintegrierten Lernen in der Zielsprache Deutsch zeigen die Entwicklungsschritte zu CLILiG eindeutig globale Spuren. Unabhängig von den oft kontextspezifischen Schwerpunkt- und Zielsetzungen der Entwicklungsarbeit lassen sich über einzelne Länder und Regionen hinweg systematisch drei Themenbereiche festhalten, die für die künftige Etablierung und Weiterentwicklung des CLILiG-Ansatzes als essenziell gelten können:
-	Erstellung geeigneter Lehr-, Lern- und Diagnosematerialien,
-	Entwicklung CLILiG-spezifischer Lehrerbildungsstrukturen sowie
-	Organisation und Systematisierung entsprechender Forschungsbegleitung.
Auf einer solchen empirischen Evidenzbasis kamen Bildungsexpertinnen und -experten aus 25 Ländern im Rahmen des internationalen Fachsymposiums CLILiG GLOBAL 2016 zusammen, um sich über Grundlagen, Praxiserfahrungen und Entwicklungsperspektiven in den drei Kernbereichen der internationalen CLILiG-Entwicklungsarbeit auszutauschen. Die vorliegende Publikation gibt einen umfassenden Überblick über die Beiträge und die Ergebnisse des Symposiums.
Comparative evaluation of stroke volume variation and inferior vena cava distensibility index for prediction of fluid responsiveness in mechanically ventilated patients
Authors: Kaur Kaminder Bir , Nakra Monish , Mangal Vishal , Singh Shalendra , Taank Priya , Marwah Vikas 
Published: March 2023

Objectives:
To evaluate the correlation between stroke volume variation (SVV) and inferior vena cava distensibility index (dIVC) as a marker for fluid responsiveness in mechanically ventilated hypotensive intensive care unit (ICU) patients.

Methodology and Design:
This study is designed as prospective observational study conducted in patients admitted to an ICU who were mechanically ventilated and experienced a hypotensive episode.

Intervention:
A fluid challenge of 10 mL/kg ringer’s lactate was given over 20 min.

Measurements:
Hemodynamic parameters as well as SVV, IVCmax, IVCmin, dIVC, and cardiac output (CO), were recorded at a different time interval. An increase in ≥15% of CO was taken as fluid responsiveness.

Results:
Out of 67 patients, 67.2% responded to fluid challenge. Pearson’s correlation graph at baseline showed a strong positive correlation between dIVC and SVV with r = 0.453, (P < 0.002). Non-responders also had a strong positive correlation (r = 0.474) at the baseline. Bland Altman’s analysis of the correlation between dIVC and SVV post-fluid challenge showed a mean difference of – 4.444, with 1.49% of the values falling outside the limits of agreement (18.418 and -27.306). This difference was clinically significant. Pearson’s correlation graph post-fluid challenge showed a moderately strong positive correlation between dIVC and SVV with r = 0.298 and P value = 0.047, which was statistically significant. Also, non-responders had a weak correlation as compared to the responder’s group, r = 0.364 and P value = 0.095, which was not clinically significant. There was no significant difference in the trend of dIVC and SVV values between the non-surgical and surgical groups, nor was there any gender difference analyzed in the study.

Conclusion:
This study ascertains the positive correlation between dIVC and SVV and justifies its use in a clinical setting of hypotension suspected to be due to hypovolemia.
Noninvasive continuous arterial pressure monitoring during anesthesia induction in patients undergoing cardiac surgery
Authors: Frank Paul , Logemann Frank , Gras Clemens , Palmaers Thomas 
Published: March 2023

Objective:
In this study we compared noninvasive arterial pressure measurement using ClearSight™ vascular-unloading-technique (Edwards Lifesciences Corp, Irvine, CA) with invasive arterial pressure measurement during induction of anesthesia undergoing mayor cardiac surgery.

Design:
Prospective, monocentric.

Setting:
University hospital.

Participants:
54 patients undergoing mayor cardiac surgery.

Interventions:
During induction all patients were simultaneously monitored with invasive (reference method) and noninvasive arterial pressure measurement (test-method) over a mean time period of 27 minutes.

Measurements and Main Results:
We observed slightly lower systolic and mean arterial pressures noninvasive than invasive. For systolic arterial pressure the mean of the differences was -18,05 mmHg (p < 0,05, SD ±16,78 mmHg), the mean arterial pressure MAP -5,47 mmHg (p < 0,05, SD ±11,08 mmHg) and for diastolic pressure -1,09 mmHg (p < 0,05, SD±11,15 mmHg),. The mean of the differences in heartrate was 1,15 (p < 0,05, SD±6,9 mmHg). When considering all measured values of the invasively measured MAP and the ClearSight ™ -MAP at the same timestamp over the recording interval, an almost identical progress can be seen that indicates a sufficient mapping of the hemodynamic changes. The percentage error for mean arterial, systolic and diastolic pressure measured by ClearSight™ amounts to 25,95 %, 26,77 % and 34,16 %, respectively.

Conclusions:
We conclude that ClearSight ™ is a good option for hemodynamic monitoring during induction of anesthesia. Taking into account the limitations, non-invasive arterial blood pressure measurement offers sufficient security to safely initiate anesthesia, especially when MAP is of particular interest. The use of non-invasive arterial blood pressure measurement with ClearSight ™ during induction of anesthesia in patients scheduled for major cardiac surgery is reliable and easy to use.