bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics
Authors: Guo Andong , Wu Chenrui , Cao Jishuang , Zhu Kejia , Ding Sentai 
Published: January 2025

ObjectiveThis study aimed to explore the clinical relevance of Human Epidermal Growth Factor Receptor 2 (HER2) in urothelial carcinoma (UC) and its association with glycolytic metabolic markers, insulin resistance, and beta-cell function, shedding light on potential therapies targeting both HER2 pathways and cancer metabolism.MethodsIn this retrospective analysis, 237 UC patients from the Departments of Urology and Pathology at Shandong Provincial Hospital were examined. From 1 January 2023, to 1 October 2024, patients underwent HER2 testing using immunohistochemistry (IHC). We investigated the relationships between HER2 expression and metabolic indicators such as the Homeostatic Model Assessment for insulin resistance (HOMA-IR), beta-cell function (HOMA-β), the triglyceride-glucose (TyG) index, and lactate dehydrogenase (LDH) levels. HER2 status was determined using a standardized scoring system from the 2021 Clinical Pathological Expert Consensus on HER2 Testing in UC, China. Statistical analysis followed CDC guidelines, using multivariate logistic regression to assess the independent impacts of HER2 on metabolic traits.ResultsOf the 237 evaluated UC samples, 87.76% exhibited positive HER2 expression. A significant correlation was found between positive HER2 status, advanced tumor stages, and increased LDH levels, suggesting a link between HER2 expression and heightened glycolytic activity. No significant relationships were observed between HER2 status and TyG levels, HOMA-IR, or HOMA-B. Subgroup analyses confirmed the consistency of the relationship between HER2 expression and LDH levels across different demographics and lifestyle factors.ConclusionOur findings confirm the significant role of HER2 as a prognostic marker and therapeutic target in UC. The association of HER2 positivity with advanced tumor stages and high LDH levels underscores its complex involvement in disease progression. This study highlights the need to explore HER2’s biological mechanisms further and pursue combined therapeutic strategies.
Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
Authors: Quarracino C. , Capani F. , Otero-Losada M. , Rodríguez G. E. , Pérez-Lloret S. 
Published: January 2025

PurposeTo explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).MethodsFrom the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure &gt; 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.ResultsAt baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.ConclusionIn a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.
Survivability of Probiotic Microflora in Fermented and Non-Fermented Mare’s Milk: A Comparative Study
Authors: Mituniewicz-Małek Anna , Ziarno Małgorzata , Dmytrów Izabela , Szkolnicka Katarzyna 
Published: January 2025

This study discusses the properties of mare milk as a potential food matrix to produce functional dairy products. The aim of this study was to investigate the effects of cold storage on the viability of microflora in fermented and unfermented mare’s milk, containing live monocultures of probiotic bacteria, during storage at low temperatures. Three fermented beverages were produced, differentiated by the bacterial flora used for production (Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12), as well as one unfermented beverage (using 40% commercial kumis and 7% LA-5). The unfermented beverage was mare’s milk supplemented with a BB-12 monoculture, which was chilled immediately after adding the inoculum. The population of BB-12 remained above 6 log CFU/g until the 21st day of storage at 5 ± 1 °C, while for LA-5, it remained viable only up to 14 days of storage. The BB-12 population was high and stable for 21 days in both fermented and unfermented beverages. The results confirm the good quality of the final product (appropriate pH and high population of individual bacterial strains); not only are appropriate culture conditions important, but the use of suitable probiotic bacteria and the optimization of the starter concentrations should also be considered. There is considerable potential for further research and future commercialization of mare’s dairy products, such as yogurt and potentially other dairy products.
Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate
Authors: Setti Giacomo , Caramaschi Stefania , Barile Giuseppe , d’Amati Antonio , Forte Marta , D’Albis Giuseppe , Bellini Pierantonio , Garuti Giovanna , Limongelli Luisa , Capodiferro Saverio 
Published: January 2025

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion that may arise from the oral mucosa consisting in an ulcerative lesion usually localized in the tongue or cheek. Palate localization is very rare. Background/Objectives: The aim of this study is to describe a case of TUGSE occurring in the hard palate of an 83 y.o. female patient, manifesting as a non-painful growing palatal lesion approximately of 3.5 × 2 cm with firm consistency and a central area of erosion and erythema, the difficulties in clinical diagnosis, and the criteria for the differential diagnosis. Also, considering the rare occurrence of TUGSE in the palate, we performed a review of the literature too. Methods: A comprehensive review of the literature was conducted following the 2020 PRISMA guidelines and a total of seven records were identified as matching the inclusion criteria of this study. Results Conclusions: Although TUGSE is a benign lesion, the clinical presentation as a proliferative and ulcerative lesion may be challenging for clinicians mainly when arising in rare sites of occurrence (e.g., the hard palate).
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Biomarker in Age-Related Macular Degeneration
Authors: Camacho Pedro , Ribeiro Edna , Pereira Bruno , Nascimento João , Caldeira Rosa Paulo , Henriques José , Barrão Sandra , Sadio Silvia , Quendera Bruno , Delgadinho Mariana , Ginete Catarina , Silva Carina , Brito Miguel 
Published: January 2025

Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospectively enrolled and stratified by disease severity: eAMD, iAMD, nAMD, and aAMD. Comprehensive ophthalmological assessments were performed, including best-corrected visual acuity, digital color fundus photographs, and Spectral Domain Optical Coherence Tomography. Peripheral blood samples were collected for RNA extraction and qRT-PCR to access epigenetic effectors’ transcriptional expression, namely DNMT1, DNMT3A, and DNMT3B genes. The collected data were analyzed using IBM SPSS 29. Results: DNMT1 expression was significantly downregulated in late AMD (−0.186 ± 0.341) compared to early/intermediate AMD (0.026 ± 0.246). Within late AMD, aAMD exhibited a marked downregulation of DNMT1 (−0.375 ± 0.047) compared to nAMD (0.129 ± 0.392). DNMT3A and DNMT3B showed similar divergent expression patterns, correlating with disease stage. Conclusions: This study identified stage-specific transcriptional differences in DNMT expression, emphasizing its potential as a biomarker for AMD progression and a target for future research into personalized therapeutic strategies.
MONITORING KEBOCORAN AIR MENGGUNAKAN MIKROKONTROL ARDUINO UNO BERBASIS APLIKASI MOBILE
Authors: Yasa I Wayan Sugara , I Wayan Suriana  , I Wayan Sukadana  
Published: January 2025

Kurang baiknya sistem monitoring instalasi air bersih selama ini dimana tidak bisa mendeteksi terjadinya kebocoran pada pipa saluran air. Banyak kerugian yaitu volume air terbuang yang merupakan selisih antara volume air terbuang sebelum dan sesudah penerapan sistem. Misalnya, jika sebelumnya terjadi kebocoran sebesar 100 liter per bulan dan setelah penerapan sistem menjadi 20 liter per bulan, maka pengurangan volume air terbuang adalah 80 liter per bulan, dan untuk biaya air terbuang yaitu biaya air yang terbuang akibat kebocoran. Misalnya, jika harga air adalah Rp 10.000 per meter kubik, dan ada kebocoran 100 liter (0,1 meter kubik) per bulan, maka biaya yang terbuang adalah Rp 1.000 per bulan. Untuk mengurangi kerugian tersebut penulis membuat rancang bangun alat monitoring kebocoran menggunakan mikrokontrol Arduino Uno berbasis aplikasi mobile. Untuk mendeteksi terjadinya kebocoran, alat ini memanfaatkan data debit air dari sensor flowmeter dan Arduino Uno sebagai mikrokontrol, sedangkan untuk pengiriman data sensor ke aplikasi mobile (Blynk) menggunakan modem dan router dengan ethernet shield sebagai fungsi LAN pada Arduino mega 2560. Hasil pengujian menunjukan bahwa alat ini dapat mendeteksi terjadinya kebocoran dengan laju debit air -> 0,1 L/m pada saat kondisi keran pada posisi OFF.
ANALISIS CALON BUPATI SLEMAN PADA PILKADA 2024 DENGAN MENGGUNAKAN NATURAL LANGUAGE PROCESSING DAN FUZZY LOGIC
Authors: Haeni Budiati  , Lase Kristian Juri Damai , Victor Crisman Mendrofa  
Published: January 2025

Munculnya nama-nama baru yang akan mengikuti bursa calon bupati Sleman dan bersaing dengan petahana menjadi trending topik di kalangan masyarakat salah satunya di sosial media twitter (X).Selama ini penilaian sentimen hanya dibagi kedalam tiga kategori yaitu positif, netral dan negatif. Fuzzy logic dapat digunakan untuk menentukan lebih dari 3 sentimen. Pada penelitian ini akan mengkolaborasikan library Textblob dengan Fuzzy Logic. Dengan mengambil nilai polarity yang dihasilkan dari library Textblob, selanjutnya akan diolah dengan menggunakan metode fuzzy untuk mendapatkan hasil kedalam 7 sentimen yaitu positif kuat, positif, positif lemah, netral, negatif lemah, negatif dan negatif kuat. Model akan dikembangkan menggunakan machine learning, dengan algoritma Support Vector Machines (SVM) untuk mengidentifikasi dan mengklasifikasikan ulasan ke dalam kategori sentimen yang sesuai. Selanjutnya, model akan dievaluasi dengan confusion matrix untuk memperoleh nilai parameter seperti accuracy, precision, recall dan f1-score. Hasil dari penelitian ini, menunjukkan peningkatan yang signifikan pada kategori netral sebesar 19,21%. Nilai akurasi rata-rata 70,4% hal ini menunjukkan kinerja sistem cukup baik; Sedangkan pada pengembangan model dengan metode SVM kategori negatif kuat memperoleh nilai presisi tertinggi yaitu 0,79. Pada kategori Positive Lemah model mendapatkan presisi (0,65), recall(0,56) dan f1-score (0,60 ); ini menunjukkan bahwa performa model seimbang.
Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions
Authors: Lee Learn-Han 
Published: January 2025

Depression affects approximately 280 million people worldwide, representing a significant public health burden. It is characterized by persistent sadness, anhedonia, fatigue, sleep disturbances, cognitive dysfunction, and in severe cases, suicidal ideation. The pathophysiology is often attributed to neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and inflammation. Recently, the gut-brain axis has garnered attention for its role in mood regulation, suggesting that probiotic supplementation may influence depressive symptoms through gut microbiome modulation. Therefore, this review examines recent findings and research gaps regarding the efficacy of probiotics in managing clinically diagnosed depression. Emerging research demonstrates that daily probiotic supplementation from 3×109 CFU to 9×1011 CFU for four to eight weeks in combination with antidepressants is effective in improving depressive symptoms. Effective formulations commonly included Bifidobacteria, Lactobacilli, Lactococcus lactis, and Streptococcus thermophilus. Nevertheless, significant gaps remain, particularly concerning the mechanistic pathways, comparative effectiveness, and impact across different demographics of the probiotics. Furthermore, the long-term effects of probiotic use with antidepressants, their role in reducing antidepressant side effects, and combined effects with psychotherapy are largely understudied. Addressing these gaps through standardized methodologies will enhance evaluations of probiotic strains to optimize microbiome-based treatment regimens, and ultimately improve mental health outcomes in depression management.

Graphical abstract. Summary of research gaps and future directions to determine the efficacy of probiotics in diagnosed depression.
Results on Enhanced Continuous Random Variable’s Probability Distribution Using a Different Exponential Function for the Normal Probability Distribution
Authors: Rao C V 
Published: January 2025

In the history of probability and statistics, general normal probability has played an important role. I utilize a different exponential function to create a new continuous probability density function akin to the Laplace Gauss distribution function. Finding an alternate probability distribution is required so that the probability can be determined without referring to the table data. I noticed that the findings are pretty comparable to the normal probability distribution values. I checked the new results against a few standard cases. The advantage of this exponential function is that we can calculate the probability of a z value with more than two decimals, whereas with a normal distribution, we can only use z values with two decimals.
Makna Kursi Dalam Surat Al-Baqarah (2):255 Anlisis Semiotika Roland Barthes
Authors: Maulana Akbar Firdaus 
Published: January 2025

Tulisan ini membahas tentang makna kursi yang terdapat pada QS Al-Baqarah (2) 255 Allah berfirman: “Allah, tidak ada tuhan selain Dia, Yang Maha Hidup lagi terus-menerus mengurus makhluk. Dia tidak dilanda oleh kantuk dan tidak pula oleh tidur. Milik-Nyalah apa yang ada di langit dan apa yang ada di bumi. Tidak ada yang dapat memberi syafaat di sisi-Nya tanpa izin-Nya. Dia mengetahui apa yang ada di hadapan mereka dan apa yang ada di belakang mereka. Mereka tidak mengetahui sesuatu apa pun dari ilmu-Nya, kecuali apa yang Dia kehendaki. Kursi-Nya meliputi langit dan bumi. Dia tidak merasa berat memelihara keduanya. Dialah yang Maha Tinggi lagi Maha Agung”. Makna kursi selama ini diartikan oleh masyarakat adalah ilmu dan kekuasan. Padahal kata kursi memiliki banyak makna apabila dikaji menggunakan banyak kitab tafsir dan penafsiran ulama. Penelitian ini bertujuan untuk menemukan beragam pemaknaan kursi dengan menggunakan pendekatan Roland Barthes yaitu denotasi dan konotasi. Untuk mencapai tujuan tersebut, penelitian ini menyimpulkan bahwa makna kursi pada tingkat denotasi ialah ilmu dan kekuasaan Allah, dan ketika naik pada Tingkat kedua konotasi kursi mendapatkan perluasan makna menjadi Allah maha kuasa atas seluruh hambanya, dan akhirya sampai pada mitos yaitu Tidak ada yang sebanding dengan Allah Swt didunia ini.
This paper discusses the meaning of the chair found in QS Al-Baqarah (2) 255 Allah says: “Allah, there is no god but He, the Ever-Living, is constantly taking care of creation. He is not stricken by drowsiness nor by sleep. To Him belongs what is in the heavens and what is in the earth. No one can intercede with Him without His permission. He knows what is before them and what is behind them. They know nothing of His knowledge, except what He wills. His Kursi encompasses the heavens and the earth, and He does not find it hard to maintain them. He is the Most High, the Most Great”. The meaning of Kursi has been interpreted by the community as knowledge and power. In fact, the word Kursi has many meanings when studied using many books of tafsir and interpretations of scholars. This research aims to find various meanings of kursi by using Roland Barthes' approach, namely denotation and connotation. To achieve this goal, this study concludes that the meaning of the chair at the denotation level is the knowledge and power of Allah, and when it rises to the second level of connotation, the chair gets an expansion of meaning to become Allah omnipotent over all his servants, and finally arrives at the myth that there is nothing comparable to Allah Swt in this world.
IMPLEMENTATION OF VILLAGE OWNED ENTERPRISE PROGRAM POLICY IN LAMU VILLAGE, TILAMUTA DISTRICT, BOALEMO DISTRICT
Authors: Poliyama Magfirah , Tui Fenti Prihatini , Tantu Romy 
Published: January 2025

<em>This study aims to determine and analyze the Policy Implementation of the Village-Owned Enterprise Program in Lamu Village, Tilamuta District, Boalemo Regency, in terms of Communication, Resources, Disposition and Bureaucratic Structure. This research method uses a qualitative approach with a type of Qualitative Descriptive research, while the data collection techniques used are observation and documentation. Based on the results of research analyzed in the field that (1) the Policy Implementation Process of Village-Owned Enterprises Program in Lamu, Tilamuta District, Boalemo Regency includes aspects Communication carried out by managers with the community, it is sufficient to be applied by BUMDes managers because the information obtained is clear in terms of information, transparency of the BUMDes ProgramHowever, there are still people who do not know the programs implemented because the community does not attend meetings held by the Village Government and BUMDes Management. Resources, which exist in the management of BUMDes are quite good, in this case Human resources can beseen from the managers of BUMDes have greatly supported the success of existing BUMDes activities , but in terms of facilities that support BUMDes program policies have not been fulfilled properly. Disposition, the executors of Village-Owned Enterprises behave in accordance with the existing rules in BUMDes, but have not been optimal and professional in carrying out their duties and functions because managers still need to learn and need guidance, in addition to the attitude of the management that is not open, and the Bureaucratic Structure, regarding the BUMDes Program do well based on AD / ART regulations and SOPs so that the programs carried out are not neglected / failed.</em>
Treating the System: A Systematic Review of Addressing Social and Family Relationship Factors for Loneliness in Transitioned-aged Youth
Authors: Dar Danishwar Rasool , Sobhana H. 
Published: January 2025

Abstract
Research highlights transitioned-aged youths are disproportionately affected by loneliness, identifying this age group as a significant “hotspot” compared to other age groups. Globally, loneliness is considered the present-day pandemic of the technological era, causing psychological distress such as depression and anxiety. Using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, this paper aimed to identify emerging themes in a systematic approach addressing social and family relationship factors for loneliness in transitioned-aged youth youth. The overarching thematic operation was guided by a research question: How do social and family relationship factors effect the loneliness and emotional wellbeing of transitioned-aged youth? Searches were conducted on APA PsycINFO, Scopus, PubMed, Cochrane Library, and Google electronic databases. From the included 65 articles, the unique findings of emerged themes were: “family relationships,” “impaired social and emotional connections,” “relational interactions and conflict,” “distress and loneliness,” “family engagement challenges in youth mental health,” “collectivism and loneliness,” “self and loneliness,” and “pathways of mental health services.” Social and family relationships are important factors for addressing loneliness during the formative years of youth. These are potential constructs and critically pertinent in understanding the underlying relational dynamics for effective intervention pathways.
Evaluating the Antiviral Effectiveness of Different Medications in Treating Respiratory Conditions: A Thorough Meta-analysis of Drug Interventions for Acute Bronchiolitis and Bronchitis
Authors: Almadhi Afnan Yousef , Aldhuwayhi Fahad Albdulaziz , Alharbi Khalid Abdulrahim , Alhasan Jumana Hani , Abdullah Layla , Alotaibi Ghaida Abdullah , Alfagieh Arwa Mohammed , Alawad Fatema Hani , Aldanyowi Saud Nayef 
Published: January 2025

Abstract

Background:
Bronchiolitis, predominantly associated with respiratory syncytial virus (RSV), is a major cause of acute lower respiratory tract infections. Recent studies underscore RSV’s significant impact, challenging previous assumptions and revealing associations with other respiratory viruses. Despite its prevalence, current treatments for bronchiolitis are primarily supportive, with no routine use of specific antiviral drugs. Similarly, acute bronchitis, affecting 5% of adults annually, is primarily caused by viruses, with Mycoplasma pneumoniae and potential contributions from Chlamydia pneumoniae as non-viral agents. The distinct aetiologies of bronchiolitis and acute bronchitis emphasise the need for a nuanced approach to their management and further research to enhance understanding and treatment strategies.

Objective:
The objective of this meta-analysis is to systematically assess the antiviral capabilities of different drugs, aiming to offer evidence-based insights into their effectiveness for treating patients with acute bronchiolitis and bronchitis.

Materials and Methods:
Statistical analyses were conducted using R software 4.2.2, including mean differences (standard deviation) with a 95% confidence interval (CI) for continuous outcomes. Heterogeneity was assessed using Cochrane Q P value and I² statistic with both random-effects and common effect models. Publication bias was evaluated through funnel plots and Egger’s regression test.

Results:
The meta-analysis demonstrates a significant positive impact of antiviral medication on acute bronchitis, with a mean difference of 5.4027 (95% CI: 4.5771–6.2283, P < 0.0001). However, substantial heterogeneity amongst studies (P < 0.001) emphasises the need for further exploration into sources of variation. A cautious interpretation, considering study characteristics, is crucial for a comprehensive understanding.

Conclusion:
The meta-analysis indicates a significant positive effect of antiviral medication on acute bronchitis. However, the presence of notable heterogeneity amongst the studies emphasises the need for careful interpretation and further exploration into potential sources of variation. Despite these challenges, the findings suggest the potential efficacy of antiviral medication in treating acute bronchitis, providing valuable insights for clinical practice.