bluuebunny/crossref_metadata_2025_split huggingface dataset:
A radiomics-based deep learning approach to predict progression free-survival after tyrosine kinase inhibitor therapy in non-small cell lung cancer
Authors: Lu Chia-Feng , Liao Chien-Yi , Chao Heng-Sheng , Chiu Hwa-Yen , Wang Ting-Wei , Lee Yen , Chen Jyun-Ru , Shiao Tsu-Hui , Chen Yuh-Min , Wu Yu-Te 
Published: January 2023

Abstract
Background
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a first-line therapy for non-small cell lung cancer (NSCLC) with EGFR mutations. Approximately half of the patients with EGFR-mutated NSCLC are treated with EGFR-TKIs and develop disease progression within 1 year. Therefore, the early prediction of tumor progression in patients who receive EGFR-TKIs can facilitate patient management and development of treatment strategies. We proposed a deep learning approach based on both quantitative computed tomography (CT) characteristics and clinical data to predict progression-free survival (PFS) in patients with advanced NSCLC after EGFR-TKI treatment.

Methods
A total of 593 radiomic features were extracted from pretreatment chest CT images. The DeepSurv models for the progression risk stratification of EGFR-TKI treatment were proposed based on CT radiomic and clinical features from 270 stage IIIB-IV EGFR-mutant NSCLC patients. Time-dependent PFS predictions at 3, 12, 18, and 24 months and estimated personalized PFS curves were calculated using the DeepSurv models.

Results
The model combining clinical and radiomic features demonstrated better prediction performance than the clinical model. The model achieving areas under the curve of 0.76, 0.77, 0.76, and 0.86 can predict PFS at 3, 12, 18, and 24 months, respectively. The personalized PFS curves showed significant differences (p < 0.003) between groups with good (PFS > median) and poor (PFS < median) tumor control.

Conclusions
The DeepSurv models provided reliable multi-time-point PFS predictions for EGFR-TKI treatment. The personalized PFS curves can help make accurate and individualized predictions of tumor progression. The proposed deep learning approach holds promise for improving the pre-TKI personalized management of patients with EGFR-mutated NSCLC.
Menstrual cup and risk of IUD expulsion – a systematic review
Authors: Bowman Nicola , Thwaites Annette 
Published: January 2023

Abstract
Background
The menstrual cup is a safe, cost-effective, and environmentally friendly menstrual product which is increasing in usage, especially in younger women. The potential risk for concomitant menstrual cup use to increase IUD expulsion has been raised over the last 10 years, however, few studies assess this. This systematic review aims to identify, appraise and synthesize the current specific evidence on menstrual cup use and risk of partial or total IUD expulsion.

Methods
PubMed, and the Cochrane Library were searched for publications available in English, until February 20th, 2021. Quantitative and qualitative studies, systematic reviews and case series reports were included. Websites of menstrual cup manufacturers LenaCup®, DivaCup®, Lunette®, AllMatters® and Saalt® were searched for warnings relevant to IUD expulsion.

Results
Seven studies were included in this review, comprising 73 partial or total IUD expulsion events in patients with IUD contraception using menstrual cups. The case study reports included two individuals who each experienced two and three expulsions respectively. Of the seven publications, three reported expulsion rates of 3.7%, 17.3% and 18.6%. Time to expulsion ranged from less than one week to two and a half years. These three studies disagree on whether there is a statistically significant association between menstrual cup use and IUD expulsion.

Conclusion
There is a possible association between menstrual cup use and increased risk of IUD expulsion and this information should be shared with patients. However evidence is scarce and high-quality randomised controlled trials are needed to address this risk and the impact of factors such as age, menstrual cup removal technique, pelvic anatomy, IUD type, and measures such as cutting the IUD strings short or delaying menstrual cup use for a period post-insertion. This research gap is limiting patients’ ability to make informed choices regarding intrauterine contraception and menstrual management and must urgently be addressed in the context of rising IUD and menstrual cup use, particularly among a younger demographic who are seeking highly effective contraception.
Methodology: workflow for virtual reposition of mandibular condyle fractures
Authors: Matschke Jan , Franke Adrian , Franke Olufunmi , Bräuer Christian , Leonhardt Henry 
Published: January 2023

Abstract
Background
Even though mandibular condyle fractures have a high clinical relevance, their treatment remains somewhat challenging. Open reduction and internal fixation are difficult due to narrow surgical approaches, poor overview during reduction, and a possible risk of facial nerve damage. In times of technical endeavors in surgery, there is a trend towards the usage of stable CAD-CAM-implants from additive manufacturing or titanium laser sintering. Up until now, there have not been any reports of fracture treatment of the mandibular condyle using this technique.

Results and conclusion
We present a workflow for virtual repositioning of the fractured mandibular condyle, to manufacture patient-specific implants for osteosynthesis with the intention of use of resorbable metal alloys in the future.
Pathomechanisms in central serous chorioretinopathy: A recent update
Authors: Zarnegar Arman , Ong Joshua , Matsyaraja Tejaswini , Arora Supriya , Chhablani Jay 
Published: January 2023

Abstract
Background
Central serous chorioretinopathy (CSCR) is a potentially blinding choroidal disease. Despite decades of research, the pathological mechanisms of CSCR are still poorly understood. In recent years, there has been a strong emphasis on choroidal dysfunction as a primary cause of CSCR.

Main Body
The concept of the pachychoroid disease spectrum and pachychoroid-driven processes are central to current theories regarding the pathophysiological underpinnings of CSCR. Choroidal hyperpermeability and subsequent leakage of fluid seen in CSCR may be due to several causes. Among them are venous congestion, inflammation, mineralocorticoid receptor activation, systemic factors including hemodynamic changes, obstructive sleep apnea, phosphodiesterase inhibitor use, pregnancy, and genetic predispositions. Congestion of vortex veins that drain blood from the choroid may contribute to the dilation of Haller vessels and cause fluid leakage. Vortex veins exit the eye through the sclera; thus, increased scleral thickness has been proposed to be a factor in venous congestion. Asymmetric vortex vein drainage may similarly result in congestion of the local venous system. Vortex vein anastomoses may overload the venous system and form secondary to venous congestion. Recent studies suggest inflammation and mineralocorticoid activation may factor into the development of CSCR, though more research in these areas is called for. Systemic conditions and genetics may predispose individuals to develop CSCR.

Conclusions
By striving to understand the molecular and physiological mechanisms of this disease, we can better diagnose and treat CSCR to improve outcomes for patients.
Malignant cancer may increase the risk of all-cause in-hospital mortality in patients with acute myocardial infarction: a multicenter retrospective study of two large public databases
Authors: Ye Jianfeng , Zhang Luming , Lyu Jun , Wang Yidan , Yuan Shiqi , Qin Zhifeng , Liu Yu , Huang Tao , Tian Jinwei , Yin Haiyan 
Published: January 2023

AbstractBackgroundAcute myocardial infarction (AMI) and cancer are diseases with high morbidity and mortality worldwide, bringing a serious economic burden, and they share some risk factors. The purpose of this study was to determine the effect of cancer on the all-cause in-hospital mortality of patients with AMI.MethodsThis multicenter retrospective study analyzed patients with AMI from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and eICU Collaborative Research Database (eICU-CRD) in the United States. Patients were divided into two groups based on whether they had concomitant malignant cancer: cancer and noncancer groups. The outcome was all-cause in-hospital mortality. The association between the two groups and their outcomes were analyzed using Kaplan–Meier and Cox proportional-hazards regression models. Propensity score matching (PSM) and propensity score based inverse probability of treatment weighting (IPTW) were used to further adjust for confounding variables to verify the stability of the results.ResultsThe study included 3,034 and 5,968 patients with AMI from the MIMIC-IV database and the eICU-CRD, respectively. Kaplan–Meier survival curves indicated that the probability of in-hospital survival was lower in patients with cancer than in those without cancer. After adjusting for potential confounding variables using multivariable Cox proportional hazards regression, the risk of all-cause in-hospital mortality was significantly higher in the cancer than the noncancer group, and the HR (95% CI) values for the cancer group were 1.56(1.22,1.98) and 1.35(1.01,1.79) in the MIMIC-IV database and the eICU-CRD, respectively. The same results were obtained after using PSM and IPTW, which further verified the results.ConclusionsAmong the patients with AMI, the all-cause in-hospital mortality risk of those with cancer was higher than those without cancer. Therefore, when treating such patients, comprehensive considerations should be made from a multidisciplinary perspective involving cardiology and oncology, with the treatment plan adjusted accordingly.
Leading change in practice: how “longitudinal prebriefing” nurtures and sustains in situ simulation programs
Authors: Eller Susan , Rudolph Jenny , Barwick Stephanie , Janssens Sarah , Bajaj Komal 
Published: January 2023

AbstractIn situ simulation (ISS) programs deliver patient safety benefits to healthcare systems, however, face many challenges in both implementation and sustainability. Prebriefing is conducted immediately prior to a simulation activity to enhance engagement with the learning activity, but is not sufficient to embed and sustain an ISS program. Longer-term and broader change leadership is required to engage colleagues, secure time and resources, and sustain an in situ simulation program. No framework currently exists to describe this process for ISS programs. This manuscript presents a framework derived from the analysis of three successful ISS program implementations across different hospital systems. We describe eight change leadership steps adapted from Kotter’s change management theory, used to sustainably implement the ISS programs analyzed. These steps include the following: (1) identifying goals of key stakeholders, (2) engaging a multi-professional team, (3) creating a shared vision, (4) communicating the vision effectively, (5) energizing participants and enabling program participation, (6) identifying and celebrating early success, (7) closing the loop on early program successes, and (8) embedding simulation in organizational culture and operations. We describe this process as a “longitudinal prebrief,” a framework which provides a step-by-step guide to engage colleagues and sustain successful implementation of ISS.
Correlation of chronological age with dental age estimated using modified Cameriere’s method and UT-age estimation software — a cross-sectional study
Authors: T Jayapriya , Keluskar Vaishali , M Sridhar , S Lokesh Kumar , Fernandes Anabelle 
Published: January 2023

Abstract
Background
Estimating age is essential in both the analysis of human skeletal remains and assessing live persons. The third molar develops over a longer period and is hence used in age estimation for subadults. Since dental age correlates with chronological age better than other growth markers, this study aims to assess the reliability of dental age assessed using the University of Texas (UT) age estimation method and modified Cameriere’s method.

Methods
It is a retrospective cross-sectional study in which the development and maturation of mandibular third molars were examined in 600 orthopantomograms (264 males and 336 females) of South Indian individuals (16–23 years). Dental age was estimated by using an Indian-specific formula based on maturity index value and the UT-age estimation software program. The results were evaluated using the Student’s t-test for both methods and Pearson’s correlation test to compare chronological age with estimated dental age.

Results
Positive correlation was noted between chronological age and estimated dental age for males, females, and the total sample with highly statistically significant differences (p = 0.000). Modified Cameriere’s method underestimated dental age in samples ranging from less than 1 year to more than 2 years. UT-age estimation method underestimated age in samples above 20 years and overestimated age in samples below 20 years. The predictive classification of utilizing the maturity index was 79.17% accurate.

Conclusions
Dental age was negligibly over and underestimated in UT software method whereas it was overestimated in the modified Cameriere's method. To evaluate the reliability of these two methods, studies with larger sample sizes and population-specific data sets should be performed.

Graphical Abstract
Forensic implication of seized drug imitating methamphetamine with mileage in crime
Authors: Dash Sujata , Vashisht Neha , Sinha Sweta , Kumar Adesh , Goyal Kavita 
Published: January 2023

Abstract
Background
The increase in drug abuse a major global issue. Clandestine laboratories along with illegal drug trafficking and trade increase the menace. Increased confiscation of illicit drugs not only indicates the manifold rise in drug abuse in Delhi and its neighboring region but also signifies an escalation and proliferation in other drug-related criminal activities. Investigating agencies around the world are working hard to combat and eradicate this problem. The samples seized by these agencies are subsequently sent for forensic examination to rule out the presence of any illicit drugs. Few such seized crystalline samples such as “methamphetamine” were submitted for examination with a query for the identification of any scheduled substance. The analysis outline followed was physical, chemical, Fourier transform infrared spectrometer analysis for detection, identification, and confirmation of seized drug samples. The purpose of a detailed investigation regarding the identification of the crystalline sample was also to understand the criminal activities involved in the consistent seizures and the forensics behind it.

Results
The comprehensive examination identified the sample as an inorganic salt of sodium thiosulfate with the absence of contraband methamphetamine. The study on salt-imitating methamphetamine underlines its diverse uses as in adulteration, trafficking to camouflage narcotics drug and its involvement in numerous other illegal purposes which on the other hand has a very crucial impact on society and its well-being.

Conclusions
The novel findings will update the investigating agencies and other experts regarding the importance of the detection of sodium thiosulfate salt in seized samples and will well establish the foul play behind large seizures to justify the role of forensic science. This unique finding deals with a very sensitive issue that has immense social impact and needs exceptional thoughtfulness.
Detection of a de novo heterozygous ANK2 variant in a child with autism spectrum disorder and epilepsy: a case report
Authors: Morais Catarina Granjo , Quental Rita , Lourenço Lara , Guardiano Micaela , Silva Cármen , Leão Miguel 
Published: January 2023

Abstract
Background
The pathogenesis of autism spectrum disorder (ASD) is not fully clarified. Next-generation sequencing technologies have greatly enhanced the identification of new genes associated with ASD. Variants in ANK2 gene are known to correlate with a broad spectrum of clinical cardiac phenotypes, but, more recently, it has also been pointed out as a candidate gene for the etiology of ASD.

Case presentation
We report the case of a female patient with ASD and epilepsy in whom clinical exome sequencing was performed for etiological enlightenment. A heterozygous variant of uncertain significance was identified in the ANK2 gene: c.3412C > T p.(Arg1138Ter). The child was submitted to a formal cardiac evaluation, ruling out cardiovascular abnormalities. The genetic variant was searched in her parents and was negative in both, suggesting a de novo variant, which favors its pathogenicity.

Conclusions
We recognize the challenge of assessing variant pathogenicity in candidate genes for ASD, and ANK2 gene is currently not associated with neurodevelopmental disorders in the Online Mendelian Inheritance in Man database. Nonetheless, our case can be added to other published reports of de novo ANK2 variants in children with ASD and neurological phenotypes (including seizures), some without cardiac impairment. Hopefully, this study provides a more detailed phenotypical description that is often lacking, and it may contribute to a better understanding of the association between ANK2 and ASD.
Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study
Authors: Hou Ling , Huang Ke , Gong Chunxiu , Luo Feihong , Wei Haiyan , Liang Liyang , Du Hongwei , Zhang Jianping , Zhong Yan , Chen Ruimin , Chen Xinran , Pan Jiayan , Jin Xianjiang , Zeng Ting , Liao Wei , Liu Deyun , Lan Dan , Zhu Shunye , Dong Zhiya , Ma Huamei , Yang Yu , Xiong Feng , Lu Ping , Cheng Shengquan , Gu Xuefan , Jin Runming , Liu Yu , Wu Jinzhun , Xu Xu , Chen Linqi , Dong Qin , Pan Hui , Su Zhe , Liu Lijun , Luo Xiaoming , Ni Shining , Chen Zhihong , Hu Yuhua , Wang Chunlin , Liu Jing , Liu Li , Lu Biao , Wang Xinli , Wang Yunfeng , Yang Fan , Zhang Manyan , Cao Lizhi , Liu GeLi , Yao Hui , Zhan Yaqin , Dai Mingjuan , Li Guimei , Li Li , Liu Yanjie , Wang Kan , Xiao Yanfeng , Zhang Xingxing , Dong Junhua , Gu Zaiyan , Ying Lirong , Huang Feng , Liu Yanling , Liu Zheng , Ye Jin , Zhao Dongmei , Hu Xu , Jiang Zhihong , Ye Kan , Zhu Hong , Chen Shaoke , Chen Xiaobo , Wan Naijun , Xu Zhuangjian , Yin Qingjin , Zhang Hongxiao , Huang Xiaodong , Yin Jianying , Zhang Huifeng , Li Pin , Yin Ping , Fu Junfen , Luo XiaoPing 
Published: January 2023

Abstract

Context
The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited.

Objective
This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as to examine the effects of dose on patient outcomes.

Design
A prospective, observational, posttrial study (NCT03290235).

Setting, participants and intervention
Children with GHD were enrolled from 81 centers in China in 4 individual clinical trials and received weekly 0.2 mg/kg/wk (high-dose) or 0.1 to &lt;0.2 mg/kg/wk (low-dose) PEG-rhGH for 30 months.

Main outcomes measures
Height SD score (Ht SDS) at 12, 24, and 36 months.

Results
A total of 1170 children were enrolled in this posttrial study, with 642 patients in the high-dose subgroup and 528 in the low-dose subgroup. The Ht SDS improved significantly after treatment in the total population (P &lt; 0.0001), with a mean change of 0.53 ± 0.30, 0.89 ± 0.48, 1.35 ± 0.63, 1.63 ± 0.75 at 6 months, 12 months, 24 months, and 36 months, respectively. In addition, the changes in Ht SDS from baseline were significantly improved in the high-dose subgroup compared with the low-dose subgroup at 6, 12, 24, and 36 months after treatment (all P &lt; 0.05). A total of 12 (1.03%) patients developed serious adverse events. There was no serious adverse event related to the treatment, and no AEs leading to treatment discontinuation or death occurred.

Conclusions
PEG-rhGH showed long-term effectiveness and safety in treating children with GHD. Both dose subgroups showed promising outcomes, whereas PEG-rhGH 0.2 mg/kg/wk might show additional benefit.
How Should We Balance Domestic and Foreign Debts in Order to Avoid Debt Trap?
Authors: Fujita Yasunori 
Published: January 2023

Many attempts have been made to examine the effect of debts on economic growth, in order to find out the ways to avoid debt trap, where national revenue is obliged to be spent mainly for repaying debts rather than constructing infrastructures for long-term economic development, making it even more difficult to repay the debts, like Sri Lanka that fell into its worst financial crisis in 2022. In the present paper, we explore the proper debt management to avoid the debt trap, by laying out a theoretical model that incorporates both domestic and foreign debts based on Fujita (2022) and Padoan et al (2012).
Main results we obtain are summarized as follows. (1) In order to avoid the debt trap, in accordance with increase in ratio of domestic debt to GDP, , government should increase ratio of foreign debt to GDP, up to certain level of , , and reduce after that. (2) if domestic interest rate does not increase so much in accordance with increase in difference of growth rates of domestic debt and GDP, government should reduce if foreign interest rate increases; if domestic interest rate increases sharply in accordance with increase in difference of growth rates of domestic debt and GDP, government should increase if foreign interest rate increases.
Conceptualising multiple-Marking in NZE
Authors: Cetra Celeste 
Published: January 2023

AbstractOur aim with this paper is to investigate the phenomenon of multiple-marking in NZE. We endeavour to find a common label to describe different grammatical features of NZE. Three constructions are analysed here. Nonagreement inthere-existentials, multiple negation, and multiple comparison. In addition, we also examine the sub-varieties of NZE and aim to find tendencies between a standard (Pākehā English – PE) and an Indigenous variety of English (Māori English – ME). As we are interested in the role sociolinguistic factors (such as speakers’ ethnicity) play in the constructions, our data are extracted from the Wellington corpus of spoken New Zealand English. Moreover, our findings reveal that multiple-marking is frequent in NZE; that PE and ME show similar productivity in multiple-marking constructions; and that sociolinguistic factors contribute to how speakers make linguistic choices. Our paper concludes by revisiting our research questions and providing suggestions for further research.
Games and turns: Considering context in language use
Authors: Moir James 
Published: January 2023

Abstract
This paper considers the ways in which Wittgenstein’s (1958) later philosophy and his ideas on language games, as well as Sacks’ (1992) work on conversational turns, has been applied in relation to the notion of context in language use discourse studies, and in particular discursive psychology. In terms of the application of Wittgenstein, I argue that it is not simply the case that he is referring to different language games as different interactional contexts, but rather that he is making a much more complex point concerning language use by competent users within a given game. In the case of Sacks, I argue that turns within conversation cannot be simply read of as evidence of a particular (inter-)action on the analyst’s part but rather must be considered in terms of how interlocutors render to one another the intelligibility of “what is going on” within the ordering of turns.