bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of fasting blood glucose variability with all‐cause mortality in heart transplant recipients
Authors: Zheng Qiang , Liu Xing , Lan Hongwen , Guo Qiannan , Xiong Tixiusi , Wang Kan , Jiang Chen , Zhang Jing , Wang Guohua , Dong Nianguo , Shi Jiawei 
Published: April 2023

AbstractBackgroundFasting blood glucose (FBG) variability, an emerging marker of glycemic control, has been shown to be related to the risk of cardiovascular events and all‐cause mortality in subjects with or without diabetes. However, whether FBG variability is independently associated with a higher all‐cause mortality in heart transplant recipients remains unknown.MethodsWe performed a retrospective cohort study including 373 adult recipients who survived for at least 1 year after heart transplantation with a functioning graft and measured FBG more than three times within first year after transplantation. Multivariable adjusted Cox regression analyses were performed to assess the association between FBG variability and all‐cause mortality.ResultsPatients were categorized into three groups according to the coefficient of variation of FBG level: ≤7.0%, 7.0%–13.5%, and >13.5%. During a median follow‐up of 44.4 months (interquartile range [IQR], 22.6–63.3 months), 31 (8.3%) participants died. In univariate analyses, FBG variability was associated with an increased all‐cause mortality (hazard ratio [HR]: 3.00, 95% confidence interval [CI]: 1.67, 5.38; p < .001). This association remained materially unchanged in the multivariable model adjusted for components of demographics, cardiovascular history and lifestyle, hospital information, immunosuppressive therapy, and post‐transplant renal function (HR: 2.75, 95% CI: 1.43, 5.28; p = .004).ConclusionsAfter heart transplantation, high FBG variability is strongly and independently associated with an increased risk of all‐cause mortality. Our findings suggest that FBG variability is a novel risk factor and prognostic marker for heart transplantation recipients in outpatient clinic.
Aligning orthodontic education: Investigating the use of a digital app to improve the performance in managing orthodontic problems
Authors: Woolley Julian , Bister Dirk , Sherriff Martyn , Jeremiah Huw 
Published: April 2023

AbstractIntroductionGeneral dentists are qualified to manage orthodontic emergencies within their scope of practice. This may involve advice, hands‐on intervention or referral to a specialist orthodontist. This study aimed to assess the effect of an orthodontic app on dental undergraduates' ability to manage common orthodontic issues. In addition, this study aimed to determine the confidence of dental students in finding information related to orthodontic emergencies (CFI) as well as their confidence in managing orthodontic emergencies (CMOE).Materials and MethodsStudents were randomised into one‐of‐three groups, an app group, an internet group and a closed‐book, exam‐style group. All participants self‐reported their CFI and CMOE. Following this, all participants were asked to complete a multiple‐choice question (MCQ) paper based on clinical orthodontic scenarios. In addition, the app group were instructed to complete an app usability questionnaire (MAUQ).ResultsApproximately, 91.40% of students (n = 84) had not received clinical training in managing orthodontic emergencies, and 97.85% (n = 91) had not managed an orthodontic emergency clinically within the last 6 months of their training. The mean score for CFI was 0.10 out of 1.0 (SD 0.11) and CMOE was 0.28 out of 1.0 (SD 0.23). Statistically significant better MCQ scores were found in the app group, and no statistically significant difference was found between the internet and exam‐style group.ConclusionsThis study is the first to consider the use of an orthodontic app to aid in the management of orthodontic issues. It has practical implications for how mobile apps can aid in learning and can be incorporated into the wider dental field.
Automatic video analysis and classification of sleep‐related hypermotor seizures and disorders of arousal
Authors: Moro Matteo , Pastore Vito Paolo , Marchesi Giorgia , Proserpio Paola , Tassi Laura , Castelnovo Anna , Manconi Mauro , Nobile Giulia , Cordani Ramona , Gibbs Steve A. , Odone Francesca , Casadio Maura , Nobili Lino 
Published: April 2023

AbstractObjectiveSleep‐related hypermotor epilepsy (SHE) is a focal epilepsy with seizures occurring mostly during sleep. SHE seizures present different motor characteristics ranging from dystonic posturing to hyperkinetic motor patterns, sometimes associated with affective symptoms and complex behaviors. Disorders of arousal (DOA) are sleep disorders with paroxysmal episodes that may present analogies with SHE seizures. Accurate interpretation of the different SHE patterns and their differentiation from DOA manifestations can be difficult and expensive, and can require highly skilled personnel not always available. Furthermore, it is operator dependent.MethodsCommon techniques for human motion analysis, such as wearable sensors (e.g., accelerometers) and motion capture systems, have been considered to overcome these problems. Unfortunately, these systems are cumbersome and they require trained personnel for marker and sensor positioning, limiting their use in the epilepsy domain. To overcome these problems, recently significant effort has been spent in studying automatic methods based on video analysis for the characterization of human motion. Systems based on computer vision and deep learning have been exploited in many fields, but epilepsy has received limited attention.ResultsIn this paper, we present a pipeline composed of a set of three‐dimensional convolutional neural networks that, starting from video recordings, reached an overall accuracy of 80% in the classification of different SHE semiology patterns and DOA.SignificanceThe preliminary results obtained in this study highlight that our deep learning pipeline could be used by physicians as a tool to support them in the differential diagnosis of the different patterns of SHE and DOA, and encourage further investigation.
The seasonality of new‐onset refractory status epilepticus (NORSE)
Authors: Gopaul Margaret T. , Hanin Aurélie , Cespedes Jorge , Pulluru Yashwanth , Kazazian Karnig , van Baalen Andreas , Gofton Teneille E. , Gaspard Nicolas , Hirsch Lawrence J. 
Published: April 2023

AbstractThe etiology of new‐onset refractory status epilepticus (NORSE), including its subtype with prior fever known as FIRES (febrile infection‐related epilepsy syndrome), remains uncertain. Several arguments suggest that NORSE is a disorder of immunity, likely post‐infectious. Consequently, seasonal occurrence might be anticipated. Herein we investigated if seasonality is a notable factor regarding NORSE presentation. We combined four different data sets with a total of 342 cases, all from the northern hemisphere, and 62% adults. The incidence of NORSE cases differed between seasons (p = .0068) and was highest in the summer (32.2%) (p = .0022) and lowest in the spring (19.0%, p = .010). Although both FIRES and non‐FIRES cases occurred most commonly during the summer, there was a trend toward FIRES cases being more likely to occur in the winter than non‐FIRES cases (OR 1.62, p = .071). The seasonality of NORSE cases differed according to the etiology (p = .024). NORSE cases eventually associated with autoimmune/paraneoplastic encephalitis occurred most frequently in the summer (p = .032) and least frequently in the winter (p = .047), whereas there was no seasonality for cryptogenic cases. This study suggests that NORSE overall and NORSE related to autoimmune/paraneoplastic encephalitis are more common in the summer, but that there is no definite seasonality in cryptogenic cases.
Multilocus approach reveals distinct evolutionary units of the South American apapa Pellona flavipinnis (Valenciennes, 1837) (Clupeiformes, Pristigasteridae)
Authors: Ximenes Aline Mourão , Machado Valéria Nogueira , Hernandez‐Ruz Emil José , de Lima Muniz Fábio , Hrbek Tomas , Farias Izeni Pires 
Published: April 2023

AbstractThe discovery and characterization of cryptic diversity is important for conservation and management, especially for ichthyofauna, whose diversity is underestimated and understudied. Cryptic diversity is especially common in widely distributed species, and Pellona flavipinnis is one such species. Thus, the aim of the present study was to investigate and test whether P. flavipinnis harbours cryptic diversity. In this study we used the COI and control region sequences and microsatellite loci of 86–114 specimens from 11–12 locations throughout the Amazon basin, depending on the molecular marker used. We also included two COI GenBank sequences from the type locality of the species, the Paraná River. The results from COI sequences showed that P. flavipinnis from the Amazon basin presented two spatially structured lineages differentiated from P. flavipinnis from the Paraná River by 10.6%–9.8% (depending on the lineages) and 45 mutational steps. The genetic distance between the Amazon lineages was 2.4% using COI, with high population differentiation values (ФST = 0.8686 and ФST = 0.8483 for COI and control region, respectively). Among the five species delimitation methods employed, three indicated two lineages in P. flavipinnis in the Amazon basin, and all five methods indicated that the Amazonian lineages are different from that of Paraná. Results from microsatellite loci also showed that P. flavipinnis from the Amazon basin is composed of two evolutionary units. The results of 13 morphometric measurements indicated that there are no differences in shape between the P. flavipinnis lineages in the Amazon basin. The present findings suggest that there are two sympatric lineages of P. flavipinnis in the Amazon basin.
Geographical indications and traditional cultural expressions: A comparative legal analysis of the GI laws of Indonesia and India and a case study analysis
Authors: K. P. Sreenath , C. J. Anson 
Published: April 2023

AbstractMany of the geographical indications (GI) in developing countries are intellectual creations with incredible uniqueness generated by traditional communities and local people. These products are linked to the culture of that community and hence can be considered as traditional cultural expressions (TCE). Dev gangjee and Steven Van Uytsel and argued that TCE can be protected under the law of GI. Moreover, there are many similarities between GI and TCEs. These two forms share some unique characteristics that other intellectual property systems are not indulged in as well as not in concern with of many nations. Handicrafts, textile products, pottery works, jewellery works are some prime examples of TCEs protected under the law of GI in India and Indonesia. This article intends to validate the compatibility of GI laws in providing space for TCEs and give some suggestions for enhanced compatibility. Case study approach has been used as methodology and that the study presumes that the present GI laws in India and Indonesia are not capable of adequately protecting TCE.
Spiritual Experience: Its Scope, Its Phenomenology, and Its Source
Authors: Cottingham John 
Published: April 2023

AbstractThis paper looks first at the scope of religious experience, offering some representative examples of phenomena that typically give rise to spiritual experiences. This leads on a consideration of the phenomenology of such experiences – the particular way in which they present themselves to the conscious subject. Lastly, the paper tackles the vexed question of the source of such experiences, and suggests that this is best understood in terms of a (certain kind of) theistic framework.
Early Life Exposure to Above Average Rainfall and Adult Mental Health*
Authors: Pasha Mochamad , Rockmore Marc , Tan Chih Ming , Thamarapani Dhanushka 
Published: April 2023

AbstractWe study the effects of early life exposure to above average levels of rainfall on adult mental health. While we find no effect from prenatal exposure, postnatal positive rainfall shocks decrease average Center for Epidemiological Studies Depression (CESD) mental health scores by 13% and increase the likelihood of depression by 6%, a more than 26% increase relative to the mean. These effects are limited to females. We rule out prenatal stress and income shocks as pathways. Early life exposure to infectious diseases appears to play a limited role but further research is required.
Earnings, Cohort Effects, and Inter‐Generational Inequality: Evidence From the Luxembourg Income Study
Authors: Freedman Michael 
Published: April 2023

AbstractResearch suggests that inequalities between generations are most pronounced in the conservative European welfare states. However, it is likely that across all advanced capitalist societies superior earnings opportunities and steady employment are pursued at a later age due to secular labor market trends. In this paper, I examine the variation in generational inequalities across different regimes using data from the Luxembourg Income Study (LIS). The repeated cross‐sectional data allow me to trace the generational changes in income for eight countries, using both Age Period Cohort (APC) and synthetic cohort models. My results suggest that for most countries, cohorts born after 1980 have experienced lower entry‐level earning opportunities, relative to cohorts born between 1960 and 1980. However, synthetic cohort models suggest that while recent generations have suffered from successively worse entry positions, they appear to be “catching up,” which suggests that permanent “scarring effects” to lifetime earnings may not be inevitable.
Gaudin algebras, RSK and Calogero–Moser cells in Type A
Authors: Brochier Adrien , Gordon Iain , White Noah 
Published: April 2023

AbstractWe study the spectrum of a family of algebras, the inhomogeneous Gaudin algebras, acting on the ‐fold tensor representation of the Lie algebra . We use the work of Halacheva–Kamnitzer–Rybnikov–Weekes to demonstrate that the Robinson–Schensted–Knuth correspondence describes the behaviour of the spectrum as we move along special paths in the family. We apply the work of Mukhin–Tarasov–Varchenko, which proves that the rational Calogero–Moser phase space can be realised as a part of this spectrum, to relate this to behaviour at of rational Cherednik algebras of . As a result, we confirm for symmetric groups a conjecture of Bonnafé–Rouquier which proposes an equality between the Calogero–Moser cells they defined and the well‐known Kazhdan–Lusztig cells.
Supplemental Material: Physicochemical evolution and mechanism of a skarn system: Insights from the world-class Mazraeh Cu deposit, NW Iran
Authors: Rajabpour Shahrokh , al. et 
Published: April 2023

<p>Table S1: Representative EPMA analyses (in wt%) of garnet and the molecular proportions of its end-members. Table S2: Representative EPMA analyses (in wt%) of pyroxene and the molecular proportions of its end-members. Table S3: Bulk-rock major and trace elements composition of selected granodiorite samples. Table S4: Types of fluid inclusions in minerals from various hydrothermal assemblages of the Mazraeh deposit and their microthermometry results for 49 FIAs. Table S5: Oxygen, hydrogen and sulfur isotope compositions of different minerals and their calculated equilibrium fluids. </p>
Rate pressure product as a novel predictor of long-term adverse outcomes in patients after percutaneous coronary intervention: a retrospective cohort study
Authors: Jiang Zhi-Hui , Aierken Abudula , Wu Ting-Ting , Zheng Ying-Ying , Ma Yi-Tong , Xie Xiang 
Published: April 2023

ObjectivesPrevious studies have suggested that heart rate and blood pressure play important roles in the development of adverse outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). However, the relationship between the rate pressure product (RPP) and long-term outcomes has rarely been investigated. This study investigated the effects of RPP on the clinical outcomes of patients with CAD who underwent PCI.DesignIn this study, a total of 6015 patients with CAD were enrolled. All patients were from the CORFCHD-PCI (Clinical Outcomes and Risk Factors of Patients with Coronary Heart Disease after PCI) Study. They were divided into two groups according to RPP (RPP <10 269, n=4018 and RPP ≥10 269, n=1997). In addition, the median follow-up time was 32 months.ParticipantsData was obtained from 6050 patients with CAD who underwent PCI at the First Affiliated Hospital of Xinjiang Medical University from January 2008 to December 2016.Primary and secondary outcome measuresThe primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).ResultsWe found that there were significant differences between the two groups in the incidence of ACM, CM, MACCEs and MACEs (all p<0.05). Among the patients with CAD having ACM, CM, MACCEs and MACEs, the mean survival time of the low-value group was significantly higher than that of the high-value group. Multivariate Cox regression analyses showed that RPP was an independent predictor for ACM (HR=1.605, 95% CI: 1.215–2.120, p=0.001), CM (HR=1.733, 95% CI: 1.267–2.369, p=0.001), MACCEs (HR=1.271, 95% CI: 1.063–1.518, p=0.008) and MACEs (HR=1.315, 95% CI: 1.092–1.584, p=0.004) in patients with stable CAD. On the other hand, there was no significant correlation between the RPP and the adverse outcomes in patients with acute coronary syndrome.ConclusionIn summary, RPP is an independent predictor of long-term prognosis in patients with CAD who underwent PCI. A higher baseline RPP before PCI increased the risk of adverse outcomes. Compared with heart rate and blood pressure alone, RPP has a higher predictive value for adverse clinical outcomes.
Abstract 1018: Multiplex immunofluorescence and image analysis to investigate the role of the immune contexture and fibroblast activation for tumor cell budding in colorectal cancer
Authors: Zielinski Dirk , Vogtmann Rebekka , Siemon Anne , Koppel Christina , Schipper Christina , Tereshchenko Anastasiia , Platero Suso , Schildhaus Hans-Ulrich 
Published: April 2023

Abstract
The advent of immune oncology had a significant impact on the stratification of cancer patients in the past few years. Furthermore, immune cell phenotyping of the tumor microenvironment is becoming a tool not only for the identification of novel predictive biomarkers for cancer immunotherapy, but also for prognostic markers that may help to understand several mechanisms like invasion and epithelial-mesenchymal transition (EMT). We demonstrate how multiplexed immunofluorescence (mIF) assays and digital image analysis helped to investigate tumor budding in colorectal cancer by evaluating the tumor microenvironment and activated fibroblasts. Akoya Bioscience’s Opal detection system and fluorophores were optimized on LEICA Bond RX for use with human normal tonsil control tissues and FFPE colorectal cancer specimens. The 6-plex mIF panel included CD4 (clone SP35), CD8 (clone C8/144B), CD68 (clone PG-M1), FoxP3 (clone SP97), PD-L1 (clone SP263) and pan-Cytokeratin (clones AE1/AE3). In addition, FAP-alpha single-plex IHC was used to investigate reactivity of the stroma surrounding tumor cell buds.  Each single marker of the mIF panel was independently validated for specificity regarding stripping efficacy and epitope stability, and for accuracy compared to single plex bright field immunohistochemistry.  Automated image analysis and cellular phenotyping followed a workflow of custom Visiopharm apps. The tissue was segmented into regions of interest, such as areas with and without tumor cell budding, and bud microenvironment. Additional parameters like MSI (Microsatellite Instability) status and TNM classification were also taken into consideration for data analysis. The applied mIF immune cell panel and automated image analysis workflow identified a broad number of different immune cell phenotypes, including rare double- or triple-positive cell subtypes, as well as their spatial relation to tumor cell buds within the activated stroma region. This revealed new insights into the complexity of the tumor microenvironment in colorectal cancer around tumor cell buds, suggesting a potential effect of both the immune system and the stromal cells on tumor cell invasion into the surrounding tissue.
Citation Format: Dirk Zielinski, Rebekka Vogtmann, Anne Siemon, Christina Koppel, Christina Schipper, Anastasiia Tereshchenko, Suso Platero, Hans-Ulrich Schildhaus. Multiplex immunofluorescence and image analysis to investigate the role of the immune contexture and fibroblast activation for tumor cell budding in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1018.
Abstract 1049: Liquid biopsy-based comprehensive genomic profiling reveal mutational landscape in advanced breast cancer
Authors: Tang Haoran , Xie Feng , Zhang Yue , Jia Shidong 
Published: April 2023

Abstract
Introduction: Breast cancer is the most common malignancy worldwide in females, with more than 2.26 million new cases and 680 thousand of deaths in 2020. Advanced breast cancer is characterized by complicated genomic landscape and requires comprehensive genomic profiling. However, tissue biopsy is hard to get in patients with recurrent metastasis. Meanwhile, limited studies have been reported to use liquid biopsy and were not capable of reporting gene copy number loss. Here we reported a comprehensive genomic profiling study in advanced breast cancer patients using liquid biopsy.
Methods: The prospective study is part of the Predicine’s Phoenix Program, a global molecular biomarkers screening program in multiple solid tumors. Currently, the study enrolled 220 advanced breast cancer patients from 8 centers in China, who were naïve to the 1st line treatment. 10ml of blood was collected from each patient and delivered to a central lab for ctDNA analysis. The study applied PredicineCARE, an NGS-based liquid biopsy assay, to profile somatic mutations, copy number variations, and gene fusions among these patients.
Results: The study identified 793 somatic mutations and 283 copy number variants among blood samples from 220 patients. The most common altered genes were TP53(101/220, 46%), PIK3CA(77/220, 35%), BRCA2(37/352, 17%), PTEN(26/220, 12%), and ATM(24/220, 11%). Gene copy number gain incidents were identified on MYC(n=28), AKT3(n=23), FGFR1(n=18), and PIK3CA(n=16), etc. The study also reported gene copy number loss incidents through liquid biopsy, such as CDKN2A(n=17), BRCA1(n=12), TP53(n=11), RB1(n=11), BRCA2(n=10), PTEN(n=9), and ATM(n=8).
Conclusions: This study revealed the comprehensive mutational landscape of advanced breast cancer patients through liquid biopsy, providing novel biomarkers for clinical diagnosis and targeted therapy mechanism studies.
Citation Format: Haoran Tang, Feng Xie, Yue Zhang, Shidong Jia. Liquid biopsy-based comprehensive genomic profiling reveal mutational landscape in advanced breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1049.