bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 vaccination in children and adolescents with and without type 1 diabetes mellitus
Authors: Karavanaki Kyriaki , Karanasios Spyridon , Soldatou Alexandra , Tsolia Maria 
Published: August 2023

AbstractAdults with Diabetes Mellitus (DM) have increased risk of severe clinical presentation during COVID-19 infection, while children and adolescents with type 1 diabetes (T1D) have the same mild clinical course as their healthy peers, especially those with optimal glycemic control. The present review focuses on the necessity of COVID-19 vaccination among children and adolescents with T1D, and also in their non-diabetic peers. The efficacy and safety of COVID-19 vaccines are also discussed, as well as their various side-effects, ranging from common mild to very rare and serious ones. Furthermore, the results of COVID-19 vaccination of adolescents with and without T1D are reported, as well as the efficacy and concerns about childhood vaccination. It is concluded that patients with DM of all age groups should maintain optimal diabetic control in order to avoid glycemic deterioration during COVID-19 infection. Furthermore, despite the very rare and serious complications of COVID-19 vaccines, vaccination against COVID-19 is recommended for children and adolescents with T1D to prevent glycemic deterioration and rare but serious complications of COVID-19 infection.
Management of adults with Alagille syndrome
Authors: Ayoub Mohammed D. , Bakhsh Ahmad A. , Vandriel Shannon M. , Keitel Verena , Kamath Binita M. 
Published: August 2023

AbstractAlagille syndrome (ALGS) is a complex rare genetic disorder that involves multiple organ systems and is historically regarded as a disease of childhood. Since it is inherited in an autosomal dominant manner in 40% of patients, it carries many implications for genetic counselling of patients and screening of family members. In addition, the considerable variable expression and absence of a clear genotype–phenotype correlation, results in a diverse range of clinical manifestations, even in affected individuals within the same family. With recent therapeutic advancements in cholestasis treatment and the improved survival rates with liver transplantation (LT), many patients with ALGS survive into adulthood. Although LT is curative for liver disease secondary to ALGS, complications secondary to extrahepatic involvement remain problematic lifelong. This review is aimed at providing a comprehensive review of ALGS to adult clinicians who will take over the medical care of these patients following transition, with particular focus on certain aspects of the condition that require lifelong surveillance. We also provide a diagnostic framework for adult patients with suspected ALGS and highlight key aspects to consider when determining eligibility for LT in patients with this syndrome.
A Nonparametric Bootstrap Method for Heteroscedastic Functional Data
Authors: Fernández-Casal Rubén , Castillo-Páez Sergio , Flores Miguel 
Published: August 2023

AbstractThe objective is to provide a nonparametric bootstrap method for functional data that consists of independent realizations of a continuous one-dimensional process. The process is assumed to be nonstationary, with a functional mean and a functional variance, and dependent. The resampling method is based on nonparametric estimates of the model components. Numerical studies were conducted to check the performance of the proposed procedure, by approximating the bias and the standard error of two estimators. A practical application of the proposed approach to pollution data has also been included. Specifically, it is employed to make inference about the annual trend of ground-level ozone concentration at Yarner Wood monitoring station in the United Kingdom. Supplementary material to this paper is provided online.
Genetic epidemiology of late blight in Australia using ancient DNA
Authors: Caruana Brittney M. , de Boer Rudolf F , Rodoni Brendan , Cogan Noel O.I. , Edwards Jacqueline 
Published: August 2023

AbstractLate blight caused by Phytophthora infestans is the most destructive disease of potatoes worldwide and is most notable as the cause of the Irish potato famine of the mid 1840’s. Whole mitochondrial genome sequences were generated from 44 Australian, two UK and one US isolates of P. infestans stored as either herbarium specimens or as recent samples on FTA cards, spanning the period 1873–2019. Mitochondrial (mt) genome sequence comparison confirmed that over the past c. 110 years, an old A1 strain of P. infestans has been present in Australia. There was evidence, however, that P. infestans had been introduced on multiple separate occasions in the early 1900s prior to the introduction of quarantine measures. The 44 Australian samples included six infected specimens of the Australian native kangaroo apple (Solanum aviculare) collected in 1911. The P. infestans mt genome sequences from these isolates clustered with P. infestans from infected potatoes collected in Victoria (1910, 1911, 1986, 1989), South Australia (1909, 2003) and Tasmania (1910, 2019), supporting the hypothesis that Australia has one old strain that has survived since the first arrival of the pathogen into the country. The study highlights the success of Australia’s potato biosecurity setting and supports the need for ongoing surveillance and biosecurity measures to prevent the introduction of the newer more aggressive strains of the pathogen.
How do work challenges interact with health management in dairy farms?
Authors: Gotti Vinciane , Manoli Claire , Dedieu Benoît 
Published: August 2023

AbstractHerd health management is a critical issue for the future of dairy systems. The right combination of preventive and curative practices will depend on management system, level of work productivity, and self-sufficiency objectives, and will entail specific skills and work organizations. However, the combination of work dimensions and animal health management has rarely been explored in the literature on a livestock farming system scale. The Grand Ouest region of France spans a diverse array of livestock farming systems that can serve to design herd health management indicators, farming objectives and work arrangements, and explore their linkages. Here we ran semi-structured interviews on 10 dairy farms, analyzed the farmers’ discourses, and built 7 variables and 25 modalities that, for the first time, cover three components, namely herd health, farming objectives and work arrangements, and we tested various associations between these variables. Our interview data confirms that consultants and veterinarians have a key role to play in building a pool of skills adapted to various types of health management system. Data suggests linkages between prevention measures, alternative or conventional curative interventions, and work-related parameters.
Low-Thrust Lunar Capture Leveraging Nonlinear Orbit Control
Authors: Pontani Mauro , Pustorino Marco 
Published: August 2023

AbstractNonlinear orbit control with the use of low-thrust propulsion is proposed as an effective strategy for autonomous guidance of a space vehicle directed toward the Moon. Orbital motion is described in an ephemeris model, with the inclusion of the most relevant perturbations. Unfavorable initial conditions, associated with weak, temporary lunar capture, are considered, as representative conditions that may be encountered in real mission scenarios. These may occur when the spacecraft is released in nonnominal flight conditions, which would naturally lead it to impact the Moon or escape the lunar gravitational attraction. To avoid this, low-thrust propulsion, in conjunction with nonlinear orbit control, is employed, to drive the space vehicle toward two different, prescribed, low-altitude lunar orbits. Nonlinear orbit control leads to identifying a saturated feedback law (for the low-thrust magnitude and direction) that is proven to enjoy global stability properties. The guidance strategy at hand is successfully tested on three different mission scenarios. Then, the capture region is identified, and includes a large set of initial conditions for which nonlinear orbit control with low-thrust propulsion is effective to achieve lunar capture and final orbit acquisition. For the purpose of achieving lunar capture, low-thrust propulsion is shown to be more effective if ignited at aposelenium.
Influence of railway wheel tread damage on wheel–rail impact loads and the durability of wheelsets
Authors: Maglio Michele , Vernersson Tore , Nielsen Jens C. O. , Ekberg Anders , Kabo Elena 
Published: August 2023

AbstractDynamic wheel–rail contact forces induced by a severe form of wheel tread damage have been measured by a wheel impact load detector during full-scale field tests at different vehicle speeds. Based on laser scanning, the measured three-dimensional damage geometry is employed in simulations of dynamic vehicle–track interaction to calibrate and verify a simulation model. The relation between the magnitude of the impact load and various operational parameters, such as vehicle speed, lateral position of wheel–rail contact, track stiffness and position of impact within a sleeper bay, is investigated. The calibrated model is later employed in simulations featuring other forms of tread damage; their effects on impact load and subsequent fatigue impact on bearings, wheel webs and subsurface initiated rolling contact fatigue of the wheel tread are assessed. The results quantify the effects of wheel tread defects and are valuable in a shift towards condition-based maintenance of running gear, and for general assessment of the severity of different types of railway wheel tread damage.
Molecular study of the presence and transcriptional activity of HPV in semen
Authors: Faja F. , Pallotti F. , Bianchini S. , Buonacquisto A. , Cicolani G. , Conflitti A. C. , Fracella M. , Cavallari E. N. , Sciarra F. , Pierangeli A. , Paoli D. , Lenzi A. , Antonelli G. , Lombardo F. , Gianfrilli D. 
Published: August 2023

Abstract
Purpose
Human Papillomavirus (HPV) in semen represents a controversial topic. Recent evidence suggests a correlation with poor semen quality, but its detection is still unstandardized in this biological fluid. Thus, the aims of this study were to verify the ability of nested PCR to reveal HPV-DNA in semen; to evaluate association of seminal HPV with sperm parameters and risk factors for infection; to investigate the rate of HPV-DNA positivity in patients with and without risk factors; to assess HPV transcriptional activity.

Methods
We enrolled sexually active men and collected clinical and anamnestic data during andrological and sexually transmitted infections (STIs) evaluation. For each patient, we performed semen analysis and nested PCR to detect HPV-DNA in semen. In positive semen samples, we proceeded with genotyping and RNA quantification to detect HPV transcriptional activity.

Results
We enrolled 185 men (36.0 ± 8.3 years), of which 85 with (Group A) and 100 without HPV risk factors (Group B). Nested PCR was able to reveal HPV-DNA in semen, discovering a prevalence of 8.6% (11.8% in Group A and 6% in Group B, respectively). We observed no correlation between sperm quality and seminal HPV. Genital warts and previous anogenital infection were significantly associated with the risk of HPV positivity in semen. Moreover, no viral transcriptional activity was detected in positive semen samples.

Conclusions
Our study suggests that searching for seminal HPV could be important in patients both with and without risk factors, especially in assisted reproduction where the risk of injecting sperm carrying HPV-DNA is possible.
A new enigmatic lacustrine trackway in the upper Miocene of the Sierra de las Cabras (Jumilla, Murcia, Spain)
Authors: Mayoral Eduardo , Herrero Cayetano , Herrero Emilio , Martín‑Chivelet Javier , Pérez‑Lorente Félix 
Published: August 2023

AbstractA new fossil trackway is described in the upper lacustrine Miocene in the Prebetic Zone of the Iberian Peninsula, in Jumilla town (Murcia region) called Aenigmatipodus jumillensis nov. ichnogen. nov. ichnosp. This trackway consists of a pattern made up of sets of three tracks or triads, which are subparallel to each other, arranged in alternate groups. Each track presents a depression formed by a central body that is three times as long as it is wide, with straight or slightly curved walls, with two shorter bodies placed at the ends, one of the ends being shorter and more pronounced than the opposite, which is longer and stretched. All the biomechanical possibilities compatible with an anatomical design that could leave the impression of three alternate triads of tracks are analysed. The supports are only from the extremities on one side of the organism (left or right), the displacement being by translation. It is concluded that it had to be a large arthropod (metre scale), with a hexapod or decapod (less probably octopod), which had to be dragged laterally by a current in a very shallow lake or wetland environment. To date, no fossil organism is known, nor its current equivalent, that corresponds to these characteristics.
Prospection as a Sustainability Virtue: Imagining Futures for Intergenerational Ethics
Authors: Cadilha Susana , Guedes Vaz Sofia 
Published: August 2023

AbstractThis paper explores the relevance of intergenerational ethics in the context of climate change and argues that virtue ethics provides a suitable framework for addressing these ethical concerns. We suggest the inclusion of a new virtue, calledprospection, which involves cultivating the ability to think and care deeply about the future, navigate its inherent uncertainties constructively, and ensure the availability of sustainable options for future generations. We suggest that thinking and imagining sustainable futures trigger good dispositions towards future humans, non-humans and nature and that ought to be part of the definition of a good life. We posit that fostering this disposition can inspire and motivate present actions that effectively mitigate climate change. Virtue ethics implies an element of timelessness in morality because the future tends to be there by default; withprospection, the future will be there by design, reinforcing its importance in intergenerational ethics.
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Authors: El-Derany Marwa O. , Hanna Diana M. F. , Youshia John , Elmowafy Enas , Farag Mohamed A. , Azab Samar S. 
Published: August 2023

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the increasing proportion of nano-based vaccines, this review compiles and analyses how COVID-19 and nanoparticles affect lipids, amino acids, and carbohydrates metabolism. A search was conducted on PubMed, ScienceDirect, Web of Science for available information on the interrelationship between metabolomics and immunity in the context of SARS-CoV-2 infection and the effect of nanoparticles on metabolite levels. It was clear that SARS-CoV-2 disrupted several pathways to ensure a sufficient supply of its building blocks to facilitate its replication. Such information can help in developing treatment strategies against viral infections and COVID-19 based on interventions that overcome these metabolic changes. Furthermore, it showed that even drug-free nanoparticles can exert an influence on biological systems as evidenced by metabolomics.
Graphical abstract
Collective Narcissism and Hungary’s Kin-State Policy after 2010
Authors: Hettyey András 
Published: August 2023

AbstractThis article analyzes Hungary’s kin-state policy starting from the premise that the concept of collective narcissism most succinctly captures its emotional foundations. I look to substantiate this claim by examining at a wide range of sources on how Hungary feels toward neighboring states and show the preponderance of emotions connected to collective narcissism. The real-life consequences of collective narcissism are demonstrated through a case study of the relationship between Hungary and Ukraine before and after the Russian attack of 2022. Overall, I find that anger is the master emotion of Hungary’s kin-state policy, resulting in a lack of solidarity and characteristic self-centeredness in Hungary’s foreign policy, which cannot be explained by rational factors alone.
The origin of planetary winds
Authors: Kubyshkina Daria 
Published: August 2023

AbstractAtmospheric escape is a fundamental phenomenon shaping the structure and evolution of planetary atmospheres. Physics of planetary winds range from global processes such as tidal interactions with the host star, through large-scale hydrodynamic outflow, to essentially microphysical kinetic effects, including Jeans-like escape and the interaction of planetary atmospheres with stellar winds and the own magnetic fields of planets. Each of these processes is expected to be most relevant for planets of different properties and at different stages in planetary and stellar evolution. Thus, it is expected that the hydrodynamic outflow guides the evolution of hydrogen-dominated atmospheres of planets having low masses (below that of Neptune) and/or close-in orbits, while the kinetic effects are most important for the long-term evolution of planets with secondary atmospheres, similar to the inner planets in the Solar System. Finally, each of these processes is affected by the interaction with stellar winds.
Europa's Perturbed Fields and Induced Dipole Affect Energetic Proton Depletions During Distant Alfvén Wing Flybys
Authors: Huybrighs H. L. F. , Blöcker A. , Roussos E. , van Buchem C. , Futaana Y. , Holmberg M. K. G. , Goetz C. , Witasse O. 
Published: August 2023

AbstractWe investigate the causes of energetic proton (80–540 keV) depletions measured during the two most distant flybys of Europa by Galileo, E17 and E25A, which encountered the Alfvén wings. First, by simulating the proton flux with a Monte Carlo particle tracing code we investigate the effect of: electromagnetic field perturbations, the induced dipole, atmospheric charge exchange and plumes. Inhomogeneous fields associated with the Alfvén wings and the ionosphere strongly affect the depletions. For homogeneous fields the depletion along the trajectory is focused on a narrow pitch angle range and has no structure, whereas the depletion for perturbed (inhomogeneous) fields represents a wider and complex structure. Furthermore, also the induced dipole alters the depletion structure. The effect of plumes (density 2.5 × 1015 m−3) and charge exchange on the proton depletion is minor. Second, we compare the simulations to the proton measurements. The simulations with inhomogeneous fields describe the data qualitatively better than the homogeneous case, suggesting that indeed field perturbations are responsible for the measured losses. We attribute discrepancies between the simulations and the proton measurements to discrepancies between the simulated and real fields. We argue that simulating the fields along the trajectory is a good first step, but that ideally the energetic ion flux is reconstructed well to gain confidence in the interpretation of the simulated magnetic field. In conclusion, energetic ion observations along distant flybys through the Alfvén wings are suitable for isolating the characteristics of the global configuration of the magnetospheric interaction region of Europa (or other moons).
Toward Improved Real‐Time Rainfall Intensity Estimation Using Video Surveillance Cameras
Authors: Zheng Feifei , Yin Hang , Ma Yiyi , Duan Huan‐Feng , Gupta Hoshin , Savic Dragan , Kapelan Zoran 
Published: August 2023

AbstractUnder global climate change, urban flooding occurs frequently, leading to huge economic losses and human casualties. Extreme rainfall is one of the direct and key causes of urban flooding, and accurate rainfall estimates at high spatiotemporal resolution are of great significance for real‐time urban flood forecasting. Using existing rainfall intensity measurement technologies, including ground rainfall gauges, ground‐based radar, and satellite remote sensing, it is challenging to obtain estimates of the desired quality and resolution. However, an approach based on processing distributed surveillance camera network imagery through machine learning algorithms to estimate rainfall intensities shows considerable promise. Here, we present a novel approach that first extracts raindrop information from the surveillance camera images (rather than using the raw imagery directly), followed by the use of convolutional neural networks to estimate rainfall intensity from the resulting raindrop information. Evaluation of the approach on 12 rainfall events under both daytime and nighttime conditions shows that generalization ability, and especially nighttime predictive performance, is significantly improved. This represents an important step toward achieving real‐time, high spatiotemporal resolution, measurement of urban rainfall at relatively low cost.
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression
Authors: Ruan Zhe , Yin Hao , Wan Teng-Fei , Lin Zhi-Rou , Zhao Shu-Shan , Long Hai-Tao , Long Cheng , Li Zhao-Hui , Liu Yu-Qi , Luo Hao , Cheng Liang , Chen Can , Zeng Min , Lin Zhang-Yuan , Zhao Rui-Bo , Chen Chun-Yuan , Wang Zhen-Xing , Liu Zheng-Zhao , Cao Jia , Wang Yi-Yi , Jin Ling , Liu Yi-Wei , Zhu Guo-Qiang , Zou Jing-Tao , Gong Jiang-Shan , Luo Yi , Hu Yin , Zhu Yong , Xie Hui 
Published: August 2023

AbstractDue to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed to investigate the effect of metformin on the healing of osteoporotic as well as normal fractures. Type H vessels have recently been identified as a bone-specific vascular subtype that supports osteogenesis. Here, we show that metformin accelerated fracture healing in both osteoporotic and normal mice. Moreover, metformin promoted angiogenesis in vitro under hypoxia as well as type H vessel formation throughout fracture healing. Mechanistically, metformin increased the expression of HIF-1α, an important positive regulator of type H vessel formation, by inhibiting the expression of YAP1/TAZ in calluses and hypoxia-cultured human microvascular endothelial cells (HMECs). The results of HIF-1α or YAP1/TAZ interference in hypoxia-cultured HMECs using siRNA further suggested that the enhancement of HIF-1α and its target genes by metformin is primarily through YAP1/TAZ inhibition. Finally, overexpression of YAP1/TAZ partially counteracted the effect of metformin in promoting type H vessel-induced angiogenesis-osteogenesis coupling during fracture repair. In summary, our findings suggest that metformin has the potential to be a therapeutic agent for fractures by promoting type H vessel formation through YAP1/TAZ inhibition.