bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
Authors: Chen Hongxia , Bai Yunpeng , Kobayashi Michihiro , Xiao Shiyu , Barajas Sergio , Cai Wenjie , Chen Sisi , Miao Jinmin , Nguele Meke Frederick , Yao Chonghua , Yang Yuxia , Strube Katherine , Satchivi Odelia , Sun Jianmin , Rönnstrand Lars , Croop James M. , Boswell H. Scott , Jia Yuzhi , Liu Huiping , Li Loretta S. , Altman Jessica K. , Eklund Elizabeth A. , Sukhanova Madina , Ji Peng , Tong Wei , Band Hamid , Huang Danny T. , Platanias Leonidas C. , Zhang Zhong-Yin , Liu Yan 
Published: September 2023

Abstract

Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in leukemia cells, promoting their proliferation and survival. We found that PRL2 dephosphorylates CBL at tyrosine 371 and inhibits its activity toward KIT, leading to decreased KIT ubiquitination and enhanced AKT and ERK signaling in leukemia cells.

Implications:
Our studies uncover a novel mechanism that fine-tunes oncogenic KIT signaling in leukemia cells and will likely identify PRL2 as a novel therapeutic target in AML with KIT mutations.
MMP-2 Associates With Incident Heart Failure and Atrial Fibrillation: The ARIC Study
Authors: Buckley Leo F. , Agha Ali M. , Dorbala Pranav , Claggett Brian L. , Yu Bing , Hussain Aliza , Nambi Vijay , Chen Lin Yee , Matsushita Kunihiro , Hoogeveen Ron C. , Ballantyne Christie M. , Shah Amil M. 
Published: September 2023

BACKGROUND:
MMP (matrix metalloproteinase)-2 participates in extracellular matrix regulation and may be involved in heart failure (HF), atrial fibrillation (AF), and coronary heart disease.

METHODS:
Among the 4693 ARIC study (Atherosclerosis Risk in Communities) participants (mean age, 75±5 years; 42% women) without prevalent HF, multivariable Cox proportional hazard models were used to estimate associations of plasma MMP-2 levels with incident HF, HF with preserved ejection fraction (≥50%), HF with reduced ejection fraction (<50%), AF, and coronary heart disease. Mediation of the association between MMP-2 and HF was assessed by censoring participants who developed AF or coronary heart disease before HF. Multivariable linear regression models were used to assess associations of MMP-2 with measures of left ventricular and left atrial structure and function.

RESULTS:

Compared with the 3 lower quartiles, the highest MMP-2 quartile associated with greater risk of incident HF overall (adjusted hazard ratio, 1.48 [95% CI, 1.21–1.81]), incident HF with preserved ejection fraction (1.44 [95% CI, 1.07–1.94]), incident heart failure with reduced ejection fraction (1.48 [95% CI, 1.08–2.02]), and incident AF (1.44 [95% CI, 1.18–1.77]) but not incident coronary heart disease (0.97 [95% CI, 0.71–1.34]). Censoring AF attenuated the MMP-2 association with HF with preserved ejection fraction. Higher plasma MMP-2 levels were associated with larger left ventricular end-diastolic volume index, greater left ventricular mass index, higher E/e′ ratio, larger left atrial volume index, and worse left atrial reservoir and contractile strains (all
P
<0.001).

CONCLUSIONS:
Higher plasma MMP-2 levels associate with diastolic dysfunction, left atrial dysfunction, and a higher risk of incident HF and AF. AF is a mediator of MMP-2–associated HF with preserved ejection fraction risk.
Incorporating the Social License to Operate into International Investment Law: Taking Stock from the Brazilian Experience
Authors: Monebhurrun Nitish 
Published: September 2023

Abstract
The social license to operate can be broadly defined as the social acceptability of an investor’s business practices by local communities. This article argues that the social license to operate can be incorporated into international investment law by allowing for local communities’ participation. The Brazilian cooperation and facilitation of investments agreements (CFIA) are used as a benchmark to sustain this argument. I explain that the CFIAs make room for the social license to operate at a procedural and at a substantial level. First, local communities can participate in the dispute prevention procedures provided for by CFIA. By this means, they bring a third party’s perspective into the investor-State relationship by voicing its concerns on the investors’ activities. Substantially, this can be supported by the detailed provisions on corporate social responsibility enshrined in the CFIA and which can be invoked by the local communities during the dispute prevention procedure.
What Drives Corporate Saving in India?
Authors: Shukla Rashmi , Nidugala Ganesh Kumar 
Published: September 2023

Corporates have traditionally been modelled for their investment rather than saving behaviour. However, in recent times the firm-level saving has displayed an unprecedented behaviour across developed and developing economies. Corporate saving behaviour in India has also witnessed fluctuations, and this study captures a mix of aggregate and firm-level variables that may explain this behaviour. This article has three objectives (a) to understand the firm and macroeconomic factors that drive firm-level saving; (b) to examine whether the firm saving is affected by savings in preceding years; (c) to identify whether this saving behaviour of firms is for precautionary motives or not. The data set used in this article includes panel data of 2,109 publicly listed, manufacturing and service sector firms for the financial years 2004–2018. The data analysis has been done using dynamic panel-data models employing system GMM estimation with multiple robustness checks. The study findings show that firm-level saving in India is mainly driven by lagged corporate saving, Tobin’s Q, GDP growth rate, CPI inflation, and financial depth, among other factors. Additionally, empirical evidence supports the presence of dynamic persistence effect and precautionary motives for savings by firms. JEL Codes: E21, G01, G32, C33
Prunetin Triggers ROS-mediated Apoptosis through the Suppression of MAPKs/STAT-3/NF-κB-p65 Signaling Pathway in Human Osteosarcoma Cells
Authors: Gao Meng , Wang Ya , Liu Weibo , Song Zelong , Wang Xiangyu , Zhang Xuesong 
Published: September 2023

Background Osteosarcoma (OS) is a highly metastatic primary bone malignancy, and the treatment options remain inadequate. Hence, exploring innovative natural medications is required. Prunetin (PRU) is an isoflavone that has been a proven anticancer agent in numerous cancer cell lines. However, the activity of PRU against OS remains uncertain. Materials and Methods Here, we studied the anticancer activity of PRU (20 and 25 µM) on human OS cells MG-63 and investigated its latent mechanism. The PRU activity of MG-63 cells cytotoxicity, intracellular ROS, metastasis, apoptosis, anti-apoptotic proteins, MAPK/STAT-3, and AKT signaling pathways was assessed by MTT assay, DCFH-DA, DAPI, PI, AO/EB, cell adhesion, and RT-PCR analysis. Findings unveiled that PRU could constrain MG-63 cell viability and adhesion through elevated intracellular ROS and elicited apoptosis. Results Likewise, PRU (20 and 25 µM) avert the MG-63 cell proliferation, which stimulates apoptosis by the enhancement of Bax and caspases, while it diminishes Bcl-2 in a dose-dependent way. Furthermore, PRU could reduce Pin-1, and anti-apoptotic elements, as well as trigger apoptotic signaling pathways. Our data established that PRU alleviates MG-63 cell proliferation and metastasis via ROS-mediated apoptosis, which triggers MAPKs/STAT3 and AKT pathways, suggesting that PRU is a promising natural remedy for OS. In order to comprehend the therapeutic target for cancer, we assessed the effect of PRU on the expression of Pin1, which is thought to be over-expressed in many human malignancies. According to our findings, PRU specifically suppressed Pin1 expression to reduce the expression of Akt, STAT3, P38, JNK, P65, and IL-6. We evaluated the impact of PRU on the expression of Pin1, which is allegedly over-expressed in many human malignancies, to better understand the therapeutic target for cancer. Researchers state that PRU inhibited the expression of Akt, STAT3, P38, JNK, P65, and IL-6 in particular, by suppressing Pin1 expression. Conclusion Together, these results suggest that PRU may be an effective treatment for bone cancer in people by preventing Pin1 expression.
Effect of Teach-back and Douyin platform short video health education in women receiving infertility treatment
Authors: Lin Qin , Zhou Haiyan , Wu Jijun , Chen Pei , Niu Yanping , Fang Weiwei , Li Ling , Peng Ling , Fu Mengxue 
Published: September 2023

Objective To evaluate the effect of intervention by Teach-back and Douyin platform short video health education on stigma, reproductive quality of life, family intimacy and family adaptability in women receiving infertility treatment. Methods This study is a quasi-experimental study. The intervention period is 6 weeks, and the study was implemented between January 2022 and August 2022. A total of 80 women (40 in the control group and 40 in the observation group) receiving infertility treatment were included in the study. The control group was given routine health education intervention, and the observation group was given Teach-back and Douyin platform short video health education on the basis of routine health education. The Chinese version of the Infertility Stigma Scale, the Infertility Quality of Life Questionnaire and the Family Intimacy and Adaptability Scale were used to evaluate the effects before and after the intervention. Results After the intervention, the total score of stigma in the observation group was significantly lower and lower than that of the control group ( P < 0.05) and the total score of reproductive quality of life in the observation group was significantly higher than that of the control group ( P < 0.05). The dissatisfaction score of family intimacy in the observation group was significantly lower than that of the control group ( P < 0.05), and the dissatisfaction score of family adaptability in the observation group was significantly lower than that of the control group ( P < 0.05). Conclusion Teach-back and Douyin platform short video health education can reduce the stigma in women receiving infertility treatment and improve their reproductive quality of life, family intimacy and family adaptability.
Automatic echocardiographic anomalies interpretation using a stacked residual-dense network model
Authors: Nurmaini Siti , Sapitri Ade Iriani , Tutuko Bambang , Rachmatullah Muhammad Naufal , Rini Dian Palupi , Darmawahyuni Annisa , Firdaus Firdaus , Mandala Satria , Nova Ria , Bernolian Nuswil 
Published: September 2023

AbstractEchocardiographic interpretation during the prenatal or postnatal period is important for diagnosing cardiac septal abnormalities. However, manual interpretation can be time consuming and subject to human error. Automatic segmentation of echocardiogram can support cardiologists in making an initial interpretation. However, such a process does not always provide straightforward information to make a complete interpretation. The segmentation process only identifies the region of cardiac septal abnormality, whereas complete interpretation should determine based on the position of defect. In this study, we proposed a stacked residual-dense network model to segment the entire region of cardiac and classifying their defect positions to generate automatic echocardiographic interpretation. We proposed the generalization model with incorporated two modalities: prenatal and postnatal echocardiography. To further evaluate the effectiveness of our model, its performance was verified by five cardiologists. We develop a pipeline process using 1345 echocardiograms for training data and 181 echocardiograms for unseen data from prospective patients acquired during standard clinical practice at Muhammad Hoesin General Hospital in Indonesia. As a result, the proposed model produced of 58.17% intersection over union (IoU), 75.75% dice similarity coefficient (DSC), and 76.36% mean average precision (mAP) for the validation data. Using unseen data, we achieved 42.39% IoU, 55.72% DSC, and 51.04% mAP. Further, the classification of defect positions using unseen data had approximately 92.27% accuracy, 94.33% specificity, and 92.05% sensitivity. Finally, our proposed model is validated with human expert with varying Kappa value. On average, these results hold promise of increasing suitability in clinical practice as a supporting diagnostic tool for establishing the diagnosis.
Evaluation of global and regional myocardial work in hypertrophic cardiomyopathy patients by left ventricular pressure-strain loop
Authors: Xiao Chengwei , Zhao Xuebing , Sun Lijuan , Zhang Fang 
Published: September 2023

Abstract
Objective
This study aimed to investigate the value of left ventricular (LV) press-strain loop (PSL) in evaluating global and regional myocardial work (MW) in hypertrophic cardiomyopathy (HCM) patients.

Methods
A total of 30 HCM patients with interventricular septum hypertrophy (HCM group) and 35 healthy subjects (control group) were selected from First Hospital of Qinhuangdao. The general clinical data and conventional ultrasound parameters of two groups were acquired. The MW parameters were analyzed using LV PSL. The regional MW parameters in the HCM group were compared between ventricular septum and the free walls of left ventricle.

Results
The epicardial adipose tissue thickness of the HCM group was significantly greater than that of the control group (P < 0.05). Global work efficiency was significantly reduced, while global wasted work was increased in patients with HCM compared with controls (all P < 0.05). The HCM group was compared in the group, to be specific, in the HCM group, the work index, the work efficiency, and the longitudinal strain on the interventricular septum were lower than those on the free wall (all P < 0.05).

Conclusion
PSL is more effective than LVEF in assessing left ventricular systolic function in HCM and is able to quantify regional myocardial work in the ventricular septum in HCM patients with preserved LVEF, suggesting a novel idea for clinical diagnosis and assessment.
Prevalence and risk factors of urinary tract infection in kidney recipients: a meta-analysis study
Authors: Hosseinpour Masoumeh , Pezeshgi Aiyoub , Mahdiabadi Morteza Zaboli , Sabzghabaei Foroogh , Hajishah Hamed , Mahdavynia Soheila 
Published: September 2023

AbstractBackgroundA kidney recipient's urinary tract infection (UTI) can result in infectious problems and be a risk factor for less successful transplant outcomes. UTI risk factors are still controversial. The present study aimed to investigate the prevalence of UTI and its association with risk factors in kidney recipients.MethodTwenty-six papers published between 2005 and 2022 were retrieved using keywords and searching Medlib, ScienceDirect, PubMed, and other databases. If possible, the pooled prevalence of UTI in kidney recipients and odds ratio (OR) with a 95% confidence interval for each risk factor were calculated. The data were analyzed using the random effects model in R and Stata 14.ResultsThe total sample size was 72,600, with an average age of 48.7 years. The pooled prevalence of UTI was 35% (95% CI, 30–40%). The estimated risk factors for UTI were female (OR = 3.13; 95%CI: 2.35—4.17), older age (OR = 1.03; 95%CI: 1—1.05), history of UTI (OR = 1.31; 95%CI) CI: 1.05—1.63), receiving a kidney from a deceased donor (OR = 1.59; 95%CI: 1.23—2.35), long-term use of an indwelling catheter (OR = 3.03; 95%CI: 1.59—6.59), a ureteral stent (OR = 1.54; 95%CI: 1.16—2.06), diabetes (OR = 1.17; 95%CI: 0.97—1.41), hypertension (OR = 1.6; 95%CI: 1.26—2.28), acute rejection process (OR = 2.22; 95%CI: 1.45—3.4), and abnormal urinary tract anatomy (OR = 2.87; 95%CI 1.44—5.74).ConclusionThis meta-analysis revealed that UTIs are a significant problem in kidney recipients. Factors such as female sex, old age, history of UTIs, deceased donor, long-term use of an indwelling catheter, diabetes, acute rejection process, use of ureteral stent, abnormal urinary tract anatomy, and hypertension were related to an increased risk of UTIs in kidney recipients.
Were the unfinished nursing care occurrence, reasons, and consequences different between COVID-19 and non-COVID-19 patients? A systematic review
Authors: Chiappinotto Stefania , Bayram Aysun , Grassetti Luca , Galazzi Alessandro , Palese Alvisa 
Published: September 2023

Abstract
Background
Unfinished Nursing Care (UNC) has been documented also during the Coronavirus (COVID-19) pandemic; however, while several secondary studies were conducted before this period to summarise occurrences, reasons, and consequences of UNC and provide a global picture of the phenomenon, no synthesis of the evidence produced during the pandemic has been documented to date. Therefore, the aim of this review is to identify differences, if any, in the UNC occurrence, reasons, and consequences perceived by nurses caring for COVID-19 and non-COVID-19 patients.

Methods
This study is a systematic review (PROSPERO CRD42023410602). According to the Population, Exposure, Comparator, and Outcomes framework, primary comparative cross-sectional, longitudinal, and cohort studies, randomised/non-randomised controlled trials were included from Medline, CINAHL, and Scopus, collecting perceptions of nurses with tools measuring UNC between COVID-19 and non-COVID-19 patients and published in English, Italian, or Turkish. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and Johanna Briggs Quality Appraisal Tool were used, and findings were summarised narratively.

Results
Five hospital-based cross-sectional studies using the self-administered MISSCARE and UNC Survey comparing data collected (a) before the pandemic vs. in the first wave; (b) before, in the second and in the third wave; and (c) simultaneously among COVID-19 and non-COVID-19 patients in the second wave. Three main patterns emerged suggesting a higher UNC occurrence among COVID-19 patients in the first wave, less occurrence among them compared to non-COVID-19 patients in the second wave, and contrasting findings with some in favour and others in contrast to COVID-19 patients. Similar patterns emerged regarding UNC reasons while no studies investigated the UNC consequences.

Conclusions
In the first wave, COVID-19 patients were likely to be at increased risk of UNC, while in later waves non-COVID-19 patients were at increased risk of UNC. Reasons also were different across waves. Findings documented during the COVID-19 pandemic may help to prevent UNC in future disasters.
Assessment of immunization data management practices in Cameroon: unveiling potential barriers to immunization data quality
Authors: Saidu Yauba , Gu Jessica , Ngenge Budzi Michael , Nchinjoh Sangwe Clovis , Adidja Amani , Nnang Nadege Edwidge , Muteh Nkwain Jude , Zambou Vouking Marius , Mbanga Clarence , Agbor Valirie Ndip , Ousmane Diaby , Njoh Andreas Ateke , Flegere Junie , Diack Demba , Wiwa Owens , Montomoli Emmanuele , Clemens Sue Ann Costa , Clemens Ralf 
Published: September 2023

Abstract
Background
One crucial obstacle to attaining universal immunization coverage in Sub-Saharan Africa is the paucity of timely and high-quality data. This challenge, in part, stems from the fact that many frontline immunization staff in this part of the world are commonly overburdened with multiple data-related responsibilities that often compete with their clinical tasks, which in turn could affect their data collection practices. This study assessed the data management practices of immunization staff and unveiled potential barriers impacting immunization data quality in Cameroon.

Methods
A descriptive cross-sectional study was conducted, involving health districts and health facilities in all 10 regions in Cameroon selected by a multi-stage sampling scheme. Structured questionnaires and observation checklists were used to collect data from Expanded Program of Immunization (EPI) staff, and data were analyzed using STATA VERSION 13.0 (StataCorp LP. 2015. College Station, TX).

Results
A total of 265 facilities in 68 health districts were assessed. There was limited availability of some data recording tools like vaccination cards (43%), maintenance registers (8%), and stock cards (57%) in most health facilities. Core data collection tools were incompletely filled in a significant proportion of facilities (37% for registers and 81% for tally sheets). Almost every health facility (89%) did not adhere to the recommendation of filling tally sheets during vaccination; the filling was instead done either before (51% of facilities) or after (25% of facilities) vaccinating several children. Moreso, about 8% of facilities did not collect data on vaccine administration. About a third of facilities did not collect data on stock levels (35%), vaccine storage temperatures (21%), and vaccine wastage (39%).

Conclusion
Our findings unveil important gaps in data collection practices at the facility level that could adversely affect Cameroon’s immunization data quality. It highlights the urgent need for systematic capacity building of frontline immunization staff on data management capacity, standardizing data management processes, and building systems that ensure constant availability of data recording tools at the facility level.