bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Contributing to the Link between Physical Well-Being and Chronic Pain in Young People from Galicia, Northwest Spain
Authors: Karimi Roya , Prego-Domínguez Jesús , Takkouche Bahi 
Published: June 2023

Introduction: The relation between physical well-being and chronic pain is complex and involves several subjective and objective covariates. We aimed to assess the role of mediator, confounder, or interactor played by covariates, including sleep quality, physical activity, perceived stress, smoking, and alcohol drinking in the relation between physical well-being and chronic pain. Method: We used Poisson regression to obtain incidence rate ratios (IRR) of the association between physical well-being and chronic pain in a cohort study carried out among university students. We applied General Structural Equation Modeling (GSEM) to assess mediation and stratum-specific analyses to distinguish confounding from interaction. We computed Relative Excess Risks due to Interaction (RERI), Attributable Proportion (AP), and the Synergy index (S) to measure additive interaction. Results: High physical well-being is related to a large decrease in the risk of chronic pain (IRRTotal Effect = 0.58; 95% CI: 0.50–0.81). Perceived stress mediates 12.5% of the total effect of physical well-being on chronic pain. The stratum-specific IRRs of current smokers and non-current smokers were different from each other and were larger than the crude IRR (IRR = 1.49; 95% CI: 1.24–1.80), which indicates that smoking could be both confounder and interactor. Interaction analyses showed that physical activity could act as a potential interactor (RERI = 0.25; 95% CI: 0.13, 0.60). Conclusions: Perceived stress is an important mediator of the relation between physical well-being and chronic pain, while smoking is both a confounder and an interactor. Our findings may prove useful in distinguishing high-risk groups from low-risk groups, in the interventions aimed at reducing chronic pain.
Bifidobacterium longum LBUX23 Isolated from Feces of a Newborn; Potential Probiotic Properties and Genomic Characterization
Authors: Reyes-Castillo Pedro A. , González-Vázquez Raquel , Torres-Maravilla Edgar , Bautista-Hernández Jessica I. , Zúñiga-León Eduardo , Leyte-Lugo Martha , Mateos-Sánchez Leovigildo , Mendoza-Pérez Felipe , Gutiérrez-Nava María Angélica , Reyes-Pavón Diana , Azaola-Espinosa Alejandro , Mayorga-Reyes Lino 
Published: June 2023

Bifidobacterium longum is considered a microorganism with probiotic potential, which has been extensively studied, but these probiotic effects are strain dependent. This work aims to characterize the probiotic potential, based on the biochemical and genomic functionality, of B. longum LBUX23, isolated from neonates’ feces. B. longum LBUX23 contains one circular genome of 2,287,838 bp with a G+C content of 60.05%, no plasmids, no CRISPR-Cas operon, possesses 56 tRNAs, 9 rRNAs, 1 tmRNA and 1776 coding sequences (CDSs). It has chromosomally encoded resistance genes to ampicillin and dicloxacillin, non-hemolytic activity, and moderate inhibition of Escherichia coli ATCC 25922 and to some emergent pathogen’s clinical strains. B. longum LBUX23 was able to utilize lactose, sucrose, fructooligosaccharides (FOS), and lactulose. The maximum peak of bacterial growth was observed in sucrose and FOS at 6 h; in lactose and lactulose, it was shown at 8 h. B. longum LBUX23 can survive in gastrointestinal conditions (pH 4 to 7). A decrease in survival (96.5 and 93.8%) was observed at pH 3 and 3.5 during 120 min. argC, argH, and dapA genes could be involved in this tolerance. B. longum LBUX23 can also survive under primary and secondary glyco- or tauro-conjugated bile salts, and a mixture of bile salts due to the high extracellular bile salt hydrolase (BSH) activity (67.3 %), in taurocholic acid followed by taurodeoxycholic acid (48.5%), glycocholic acid (47.1%), oxgall (44.3%), and glycodeoxycholic acid (29.7%) probably due to the presence of the cbh and gnlE genes which form an operon (start: 119573 and end: 123812). Low BSH activity was determined intracellularly (<7%), particularly in glycocholic acid; no intracellular activity was shown. B. longum LBUX23 showed antioxidant effects in DPPH radical, mainly in intact cells (27.4%). In the case of hydroxyl radical scavenging capacity, cell debris showed the highest reduction (72.5%). In the cell-free extract, superoxide anion radical scavenging capacity was higher (90.5%). The genome of B. longum LBUX23 contains PNPOx, AhpC, Bcp, trxA, and trxB genes, which could be involved in this activity. Regarding adherence, it showed adherence up to 5% to Caco-2 cells. B. longum LBUX23 showed in vitro potential probiotic properties, mainly in BSH activity and antioxidant capacity, which indicates that it could be a good candidate for antioxidant or anti-cholesterol tests using in vivo models.
First Report on the Synergistic Interaction between Essential Oils against the Pinewood Nematode Bursaphelenchus xylophilus
Authors: Faria Jorge M. S. , Cavaco Tomás , Gonçalves Diogo , Barbosa Pedro , Teixeira Dora Martins , Moiteiro Cristina , Inácio Maria L. 
Published: June 2023

Control of the pinewood nematode (PWN), the causal agent of pine wilt disease, can be achieved through the trunk injection of nematicides; however, many pesticides have been linked to environmental and human health concerns. Essential oils (EOs) are suitable alternatives due to their biodegradability and low toxicity to mammals. These complex mixtures of plant volatiles often display multiple biological activities and synergistic interactions between their compounds. The present work profiled the toxicity of eight EOs against the PWN in comparison to their 1:1 mixtures, to screen for successful synergistic interactions. Additionally, the main compounds of the most synergistic mixtures were characterized for their predicted environmental fate and toxicity to mammals in comparison to emamectin benzoate, a commercial nematicide used against PWN. The mixtures of Cymbopogon citratus with Mentha piperita and of Foeniculum vulgare with Satureja montana EOs showed the highest activities, with half-maximal effective concentrations (EC50) of 0.09 and 0.05 µL/mL, respectively. For these, complete PWN mortality was reached after only ca. 15 min or 2 h of direct contact, respectively. Their major compounds had a higher predicted affinity to air and water environmental compartments and are reported to have very low toxicity to mammals, with low acute oral and dermal toxicities. In comparison, emamectin benzoate showed lower nematicidal activity, a higher affinity to the soil and sediments environmental compartments and higher reported oral and dermal toxicity to mammals. Overall, uncovering synergistic activities in combinations of EOs from plants of different families may prove to be a source of biopesticides with optimized toxicity against PWNs.
Systematic Review of the Oxford Classification of IgA Nephropathy: Reproducibility and Prognostic Value
Authors: Howie Alexander J. , Lalayiannis Alexander D. 
Published: June 2023

Key Points

The Oxford classification of IgA nephropathy defined five features scored subjectively in renal biopsies, identified by the initials MESTC.Two large studies with independent observers showed reproducibility was moderate for T, moderate or poor for M and S, and poor for E and C.In multivariate analyses including clinical features, T was related to 58% of outcomes, with no correlation of MESTC with 24% of outcomes.

Background
The Oxford classification of IgA nephropathy defined five prognostic features scored subjectively in renal biopsies: mesangial cellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), interstitial fibrosis/tubular atrophy (T), and (fibro)cellular crescents (C). Pathological scoring systems should be reproducible and have prognostic value independently of clinical features. Reproducibility of the classification was not previously investigated in a systematic review, and the most recent systematic reviews of prognostic value were in 2017.

Methods
This systematic review followed PRISMA 2020 guidelines. MEDLINE, PUBMED, and EMBASE databases were searched using the terms “IgA nephropathy” and “Oxford.” Eligible papers applied the classification and mentioned statistical analysis of interobserver reproducibility and/or included multivariate analysis of outcomes related to individual Oxford scores and clinical features, including treatment with corticosteroids or other immunosuppressive drugs.

Results
There were 99 suitable papers before September 23, 2022. Of 12 papers that mentioned reproducibility, only six reported statistics for MEST/MESTC scoring. Four of these were small studies and/or had observers at the same institution. These were considered less representative of application of the classification than two large studies with independent observers, in which agreement was moderate for T, either moderate or poor for M and S, and poor for E and C. In 92 papers with 125 multivariate analyses of various outcomes, the commonest Oxford element associated with outcomes was T (73 of 125, 58%), with no correlation of any element with outcomes in 30 analyses (24%). Treatment with immunosuppression was often related to scores, particularly C and E, without consistent relations between Oxford scores and outcomes in immunosuppressed patients.

Conclusions
This systematic review showed limitations of the Oxford classification in practice, particularly the moderate or poor reproducibility of scores. T was the Oxford score most often related to clinical outcomes, but even this was not consistently reliable as a prognostic indicator.
Subgroups of Patients with Distinct Health Utility Profiles after AKI
Authors: Kwong Yuenting D. , Liu Kathleen D. , Hsu Chi-yuan , Cooper Bruce , Palevsky Paul M. , Kellum John A. , Johansen Kirsten L. , Miaskowski Christine 
Published: June 2023

Key PointsHealth utility profiles can be identified at 60 days after AKI.Patient subgroups with distinct health utility profiles have different characteristics at index hospitalization and outcomes at 1 year.These profiles may be useful when considering resources to improve the physical and emotional health of patients after AKI.BackgroundA large amount of interindividual variability exists in health-related quality of life outcomes after AKI. This study aimed to determine whether subgroups of early AKI survivors could be identified on the basis of distinct health utility impairment profiles ascertained at 60 days after AKI and whether these subgroups differed in clinical and biomarker characteristics at index hospitalization and outcomes at 1-year follow-up.MethodsThis retrospective analysis used data from the Biologic Markers of Renal Recovery for the Kidney study, an observational subcohort of the Acute Renal Failure Trial Network study. Of 402 patients who survived to 60 days after AKI, 338 completed the Health Utility Index 3 survey, which measures impairments in eight health attributes. Latent class analysis was used to identify subgroups of patients with distinct health utility profiles.ResultsThree subgroups with distinct health utility impairment profiles were identified: Low (28% of participants), Moderate (58%), and High (14%) with a median of one, four, and six impairments across the eight health attributes at 60 days after AKI, respectively. Patient subgroups differed in weight, history of cerebrovascular disease, intensity of dialysis, hospital length of stay, and dialysis dependence. Serum creatinine and blood urea nitrogen at index hospitalization did not differ among the three subgroups. The High impairment subgroup had higher levels of IL-6 and soluble TNF receptor 2 at study day 1. The three subgroups had different 1-year mortality rates: 5% in the Low, 21% in the Moderate, and 52% in the High impairment subgroup.ConclusionPatient subgroups with distinct health utility impairment profiles can be identified 60 days after AKI. These subgroups have different characteristics at index hospitalization. A higher level of impairment at 60 days was associated with decreased survival.PodcastThis article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/K360/2023_12_01_KID0000000000000201.mp3
POLA INTERAKSI ANTARA IBU BEKERJA DENGAN ANAK SELAMA MASA PANDEMI COVID-19 (Studi Fenomenologi Ibu Bekerja di Purwakarta)
Authors: Setyasih Shinta Mustika 
Published: June 2023

Penelitian ini membahas tentang pola interaksi antara ibu bekerja dengan anak selama masa pandemi covid-19. Penelitian ini menggunakan teori utama Family Communication Patterns Theory dari Koerner & Fitzpatrick 2006. Tujuan penelitian ini untuk mengetahui bagaimana pola interaksi antara ibu bekerja dengan anak selama masa pandemi covid-19. Penelitian ini menggunakan metode penelitian kualitatif dan pendekatan fenomenologi, serta dianalisis tematik melalui software ATLAS.ti versi 8. Hasil penelitian ini menunjukan, percakapan dapat dilihat melalui tiga aspek. Pertama, interaksi melalui penerapan komunikasi terbuka dalam menyampaikan pemikiran dan perasaan, Kedua, topik melalui interaksi positif yang dilakukan ibu, dan adanya hubungan baik didalam interaksi tersebut melalui bentuk, keterbukaan masalah, hambatan masalah, mendengarkan nasehat anak, dan kendala perkuliahan. Ketiga, partisipasi melalui tanggung jawab ibu untuk membantu aktivitas anak, serta ibu berperan penting untuk kepribadian anak. Kemudian konformitas dapat dilihat melalui tiga aspek. Pertama, kebiasaan perilaku selama covid-19 yang dilakukan yakni makan dan belanja bersama, serta pengontrolan aktivitas anak seperti perkuliahan, ibadah, dan perkembangan anak. Kedua, nilai yang diterapkan pada anak yakni berbuat baik pada orang, kejujuran, tanggung jawab dan kemandirian. Ketiga, sikap yang diterapkan adalah disiplin, sabar, membersihkan rumah, dan pendekatan antara saudara. Keempat, keyakninan dimana ibu menghargai keputusan dan pendapat anak.
Analisa Wacana Pemberitaan “Tiga Anak Saya Diperkosa, Saya Lapor Polisi, Polisi Menghentikan Penyelidikan” oleh Projectmultatuli.org
Authors: Setiawan Deni 
Published: June 2023

Fokus penelitian ini untuk melihat Makna dari pemberitaan “tiga anak saya diperkosa, saya lapor polisi, polisi menghentikan penyelidikan”. Beritakan pertama kali oleh projetmultatuli.org. Mengunakan paradigma kritis deskriptif kualitatif, ditinjau dari Analisa wacana model van dijk dan menggunakan teori Ideologi dan Hegemoni Gramsci. Memperlihatkan makna sebuah berita, secara aktif baik dari sisi pembuat berita maupun dari sisi pembaca. Merupakan satu kesatuan yang utuh dengan sistem tata nilai yang berlaku di dalam kehidupan bermasyarakat. Manfaat Penelitian ini diharapkan menambah pengetahuan dan memahami sebuah makna dari suatu kejadian atau peristiwa yang terjadi, memahami peristiwa tersebut di bentuk dan disajikan menjadi pemberitaan. Hasil penelitian ini menunjukkan, Polisi tidak mengusut sampai tuntas kasus ini meski nilai human interest storynya tinggi. Polisi mengabaikan fakta – fakta yang bisa menjadi bukti permulaan yang cukup dalam melanjutkan penyidikan. Terduga pelaku merupakan Aparatur Sipil Negara, mempunyai jabatan di pemerintahan setempat. Jabatan tersebut diduga menjadi salah satu penyebab, polisi menghentikan penyelidikan. Proses penghentian penyelidikan polisi, diikuti langkah sistematis untuk mengesankan tidak terjadi tindak pidana pada kasus ini. Menggiring opini bahwa ibu korban gila, merahasiakan hasil pemeriksaan ibu korban dan visum ketiga anaknya. Pemberitaan ini, menambahkan daftar hitam ketidak profesionalan Institusi Kepolisian dalam menangani kasus tindak pidana khususnya kasus kekerasan seksual.
PENGARUH E- WOM TERHADAP MINAT BERKUNJUNG KONTEN PORNOGRAFI DAN KEPUTUSAN PEMBELIAN ONLYFANS.COM
Authors: Raujung Puti lembah , Renata Cut Deyna 
Published: June 2023

Abstrak: Peningkatan status level darurat covid-19 kota Depok pada bulan Agustus tahun 2020, dari yang sebelumnya kota Depok mendapatkan level status zona kuning kini pertanggal 1 september 2020 kota depok berubah status level kewaspadaan penularan covid-19 menjadi zona merah, peningkatan status tersebut disebabkan oleh penambahan pasien yang terindikasi positif covid-19, maka mengacu pada surat edaran dari sekretariat gugus tugas percepatan penanganan covid-19 kota depok, peningkatan jumlah angka pasien positif covid-19 di kota depok yang tertinggi berasal dari klaster perkantoran dan tempat kerja. Iklan layanan masyarakat merupakan iklan yang digunakan untuk menyampaikan,informasi persuasi,atau mendidik khalayak yang bersifat sosial agar masyarakat sebagai audiens dapat bertambah pengetahuannya, bertambah kesadaran dan sikapnya, serta berubahperilakunya agar mempunyaimpandangan positif dan kehidupan lebih baikTujuan penelitian ini untuk mengetahui seberapa besar pengaruh iklan dan media sosial BALITANGKESTV tangkal Covid-19 di tempat kerja terhadap partisipasi masyarakat Kota Depok Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian cross sectional Pengumpulan data penelitian ini menggunakan kuesioner .Sampel minimal penelitian ini dihitung menggunakan rumus Slovin sebanyak 100 orang. Hasil penelitian ini menunjukkan bahwa secara stimulan terdapat pengaruh signifikan antara variabel iklan BALITANGKESTV tangkal Covid-19 di tempat kerja terhadap partisipasi masyarakat Kota Depok.
Community Pharmacists' Attitudes, Preferences and Barriers toward Continuing Pharmaceutical Education: A Cross Sectional Study in Jordan
Authors: Saadeh Alaa , Jarab Anan S. , Jaradat Roa’a , Al Daqqa Raneem 
Published: June 2023

Community pharmacists’ responsibilities are expanding to foster optimal patient-centered care, which dictates postgraduate continuous education to enhance their competency and ability to face job challenges. We employed a cross-sectional online questionnaire-based study to evaluate community pharmacists’ attitudes towards continuous education, their preferred modes of program delivery, factors they consider before joining a program, their preferred topics to learn about, and potential perceived barriers against continuous education.
A total of 358 community pharmacists completed the questionnaire. The majority of them (86.9 %) were interested in continuous education. However, most pharmacists (70.1%) had never attended any continuous education activity before. The most preferred type of delivery was self-learning through the internet (44.2%). Program cost and location were the major factors considered before accepting any activity (96.9%, and 96.6%, respectively). Among diseases, infectious disease was the most interesting topic for community pharmacists (92.7%). Regarding pharmaceutical topics, they were mostly interested in learning pharmacology and pharmacotherapy (94.1%), whereas pregnant and nursing mothers was the most desired patient group to learn about (92.2%). Job constraints and lack of time were the most reported barriers (89.4% and 89.1%, respectively).
Community pharmacists’ have positive attitudes towards continuous education. However, many obstacles restrain them from effective participation in it. We provided sufficient data for policy makers to consider in future planning for continuous education activities that meet the needs of today’s pharmacists to advance their practice.
Characterization and Identification of Chemical Fungtional Groups in Oyster Mushroom (Pleurotus Ostreatus) Broth with edded Vegetables and Spices
Authors: Ayu MZ Siti Maulyda , Pagarra Halifah , Idris Irma Suryani , Jumadi Oslan , Hartati Hartati 
Published: June 2023

Adding the nutritional content of broth powder without destroying the distinctive taste of the broth can be done using pure mushroom extract and additional vegetables and spices. This study aims to determine the organoleptic characteristics and identify the chemical functional groups of glutamic acid in the best samples of oyster mushroom broth powder added with vegetables and spices. The results of the organoleptic test were tabulated in a table and then analyzed using a descriptive test. The organoleptic characteristics of the best color parameters were in treatment B1 which had a pale white color . The best treatment of aroma, texture, and taste parameters were found in the B2 treatment with a characteristic aroma of typical broth, fine powder texture, and has a distinctive taste of broth. The identification of the functional groups of secondary metabolites using the Fourier Transform Infrared (FTIR) instrumentation. Identification results with FTIR showed absorption at wave number (cm-1): 3419.74, 2934.62, 1639.56, 1409.70, 1055.55. There is N-H, O-H, C-H, C=O carbonyl group and carboxylic C-O, which identify the presence of amide compound, phenol acid, alkane, aldehydes, amid I and carboxylic acid, which are known as glutamic acid in this sample. Keywords: Organoleptic, Functional Groups Identification, Oyster Mushroom Broth Powder Why only B1 that you mentioned in color parameters?
Pelatihan Manajemen Laktasi pada Kader Posyandu Wilayah Kerja Puskesmas Tanjung Medang Rupat Utara
Authors: Ismawati Ismawati , Romus Ilhami 
Published: June 2023

Exclusive breastfeeding is one of the government programs to improve the nutritional status of toddlers aged 6-24 months. The World Health Organization (WHO) states that breast milk is the best source of nutrition for infants and toddlers or babies. Posyandu is a community-based health effort that is from, by, and for the community. Cadres are one of the elements that have an important role in health services such as monitoring the growth of children, toddlers and conducting counseling and providing information about maternal and child health. This is what drives this service activity which aims to increase the knowledge and skills of posyandu cadres in conducting breastfeeding counseling. This activity was carried out in the work area of the Tanjung Medang Health Center, Rupat Utara District, Bengkalis Regency from July to November 2022. The training was carried out using lecture, discussion, and question and answer methods using laptop media, projectors, and module books. This service activity was attended by 25 posyandu cadres. Most of the training participants were in the age range of 20-35 years (52%) and most of them had high school education (52%), the rest had elementary school education (24%), university (16%) ) and junior high school (8%). The results of the evaluation showed an increase in cadres' knowledge regarding lactation management. It is hoped that these cadres will then pass on their knowledge and skills to the families/mothers around them so that they can increase exclusive breastfeeding outcomes.