bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness and interest in osteopathic manipulative treatment in allopathic medical students
Authors: Darby Anne , Parascando Jessica A. , Lipinski Matthew , Lipinski Chang , Mendez-Miller Megan , Berg Arthur , Rabago David , Oser Tamara K. 
Published: May 2023

Abstract

Context
Osteopathic manipulative treatment (OMT) is utilized by clinicians to diagnose and treat a variety of musculoskeletal conditions including acute and chronic pain, and other medical conditions. Previous studies have examined attitudes of allopathic (MD) residents toward OMT and have implemented residency-based curricula; however, literature is lacking on the attitudes of MD students toward OMT.

Objectives
The objective of this study was to determine MD students’ familiarity with OMT and to evaluate their interest in an elective osteopathic curriculum.

Methods
A 15-item online survey was electronically sent to 600 MD students at a large allopathic academic medical center. The survey assessed familiarity with OMT, interest in OMT and in participating in an OMT elective, educational format preference, and interest in pursuing primary care. Educational demographics were also collected. Descriptive statistics and Fisher’s exact test were utilized for categorical variables, and nonparametric tests were utilized for the ordinal and continuous variables.

Results
A total of 313 MD students submitted responses (response rate=52.1 %), of which 296 (49.3 %) responses were complete and utilized for analysis. A total of 92 (31.1 %) students were aware of OMT as a modality in treating musculoskeletal disorders. Among the respondents who indicated “very interested” in learning a new pain treatment modality, the majority: (1) observed OMT in a prior clinical or educational setting (85 [59.9 %], p=0.02); (2) had a friend or family member treated by a DO physician (42 [71.2 %], p=0.01); (3) were pursuing a primary care specialty (43 [60.6 %], p=0.02); or (4) interviewed at an osteopathic medical school (47 [62.7 %], p=0.01). Among those interested in developing some OMT competency, the majority: (1) were pursuing a primary care specialty (36 [51.4 %], p=0.01); (2) applied to osteopathic schools (47 [54.0], p=0.002); or (3) interviewed at an osteopathic medical school (42 [56.8 %], p=0.001). A total of 230 (82.1 %) students were somewhat or very interested in a 2-week elective course in OMT; among all respondents, hands-on labs were the preferred method for delivery of OMT education (272 [94.1 %]).

Conclusions
The study found a strong interest in an OMT elective by MD students. These results will inform OMT curriculum development aimed at interested MD students and residents in order to provide them with OMT-specific theoretical and practical knowledge.
Crystal structure of methyl ((4-aminobenzyl)sulfonyl)-L-prolinate, C13H18N2O4S
Authors: Wang Zhen , Zhao Feng-Lan , Hou Gui-Ge , Meng Qing-Guo 
Published: May 2023

Abstract
C13H18N2O4S, orthorhombic, P212121 (no. 19), a = 6.8619(2) Å, b = 12.0735(4) Å, c = 16.6591(5) Å, V = 1380.16(7) Å3, Z = 4, R

gt
(F) = 0.0236, wR

ref
(F
2) = 0.0604, T = 150 K.
Bufotalin inhibits porcine kidney cortex aminopeptidase N and is cytotoxic to APN+ tumor cells
Authors: Almeida García Fabiola , Rivera Méndez Laura , Frómeta Fuentes Talía , Acén Ravelo Thalía , Alonso Bosch Roberto , Perera Wilmer H. , Arrebola Sánchez Yarini , Bergado Gretchen , Sánchez Ramírez Belinda , Charli Jean-Louis , Pascual Alonso Isel 
Published: May 2023

Abstract
Bufadienolides are steroids that inhibit the Na+/K+ ATPase pump. Recent studies show that members of the bufadienolide family also inhibit the activity of aminopeptidase N (APN). APN is upregulated in different pathologies, including cancer and is a current target for drug development. Bufadienolides are cytotoxic in tumor cells, but there is no enough evidences that inhibition of APN activity contributes to their effect. In the present contribution we investigated the effect of another member of the bufadienolide family, bufotalin, on porcine APN (pAPN) activity. Bufotalin inhibited pAPN activity with K

i
values in the submicromolar range and an uncompetitive inhibition mechanism; it also inhibited porcine aminopeptidase A (pAPA) activity, but with a classical reversible competitive inhibition mechanism. In addition, we determined the effect of bufotalin on the viability/metabolism of APN+ A549, H292, MeWo and CT26 cancer cells. Bufotalin was cytotoxic in a dose dependent manner; the highest cytotoxicity was detected in A549 cells, the cells with the highest APN activity. Thus, tumor cell line sensitivity to the cytotoxic effect of bufotalin correlates with cell surface APN activity.
Sustainable Posthumanism. Ethical Nudging and Normative Robomorphing
Authors: Costantini Cristina 
Published: May 2023

Abstract
The essay moves from a conceptual dramatization of the ‘otherification’ of the human being towards the tentative solution of all the habitual juxtapositions created by modern rationality between human/non-human, organic/inorganic, life/death, natural/artificial, animate/inanimate. A new possible vision, substantiated by literature and supported by a philosophical critical thought, transfigures the same idea of matter, opening the way to a new form of materialism which acknowledges the vitality, the liveliness of the stuff and accepts infinite bio-possibilities. The horizon of a possible ‘humanistic inhumanism’ is explored through the paradigmatic and performative representation offered by Ali Abbasi’s wonderful film ‘Border’, where montage becomes a philosophical tool to question not only the concrete potentiality of a completely reversed post-human semiotic order, but also the current normalization of ethical behaviour. All these arguments foster an articulated reflection on the transformations needed to provoke a ‘regenerative apocalypse’ of Politics and Governance for the promotion of a counter-ethic of interconnectedness.
Minding the Shift: Some Thoughts on the Human and the Not Too Human Mind
Authors: Gaakeer Jeanne 
Published: May 2023

Abstract
Software systems that claim to think for themselves may prove to be Frankenstein’s nightmare come true. When Amazon used algorithms to read digital letters of job applicants, it turned out that mentioning women sports in the category of one’s favourite leisure activities was detrimental to getting the job, i.e., the algorithm favoured male applicants. What if AI becomes able to and will in fact take over cars, elevators and other electronic devices with devastating results for their human owners or operators? In this article, I aim to address the differences between, and the possible clashes of the human and the AI minds (and their souls and hearts) by means of some examples, including a.o., drones, ADS (automatic driving systems) and our recent Artificial Friend, Kazuo Ishiguro’s fictional robot Klara, and I do so by focussing on the narratives involved, on the view that new technologies need a legal hermeneut. This article is inspired, firstly, by the novelist Samuel Butler and the today not so fictional question that he raised, i.e., whether “because mechanical life is a very different thing from ours, therefore it is not life at all?” (Samuel Butler, Erewhon [1872]. Harmondsworth UK: Penguin, 1954, 175), because Butler adds that if it is considered life it could have a will of its own as well and that may lead to dire consequences also from a point of view of law; secondly, because the topic of AI also invites us to consider the interdisciplinary question why new technologies need the humanities. As the philosopher Edmund Husserl claimed, a determination of the world by the positive sciences as took place in the second half of the nineteenth century occasioned “an indifferent turning-away from the questions which are decisive for a genuine humanity. Merely fact-minded sciences make merely fact-minded people” (Edmund Husserl, The Crisis of European Sciences and Transcendental Phenomenology, An Introduction to Phenomenological Philosophy [1954], trans. David Carr. Evanston, Ill.: Northwestern University Press, 1970, 6).
Of Sexbots, Cyborgs and Artificial Intelligence: Articulations of the Posthuman Subject in Jeanette Winterson’s Frankissstein: A Love Story
Authors: Onega Susana 
Published: May 2023

Abstract
Jeanette Winterson’s latest novel, Frankissstein: A Love Story (2019), was written as a contribution to the world-wide celebrations of the second centenary of the publication of Mary Shelley’s Frankenstein. Evincing the characteristic excessiveness and parodic stance of the postmodern romance, it alternates two interlocked story lines. The first, narrated by Mary Shelley, is situated during her own life span and populated by Mary herself, Percy Bysshe Shelley, Lord Byron, John William Polidori and Claire Clairmont. The second, situated in 2018, is narrated by Dr Ry Shelley, a transgender medical doctor who sells body parts to Prof. Victor Stein, a cutting-edge researcher in Artificial Intelligence. The essay argues that for all its parodic doubleness, temporal circularity, thematic enmeshment and palimpsestic structure, the novel draws a clear-cut distinction between the Idealist conception of subjectivity endorsed by the male Romantic poets that leads to Prof. Stein’s transmodern conception of a future universe colonised by bodiless enhanced humans, and Mary Shelley’s affectively charged conception of embodied subjectivity that foreruns Ry Shelley’s posthuman conception of fluid subjectivity.
Homo and heterometallic ruthenium and platinum complexes with multiple targets for therapeutic applications: a review
Authors: De Senjuti , Nag Samik 
Published: May 2023

Abstract
We are now well-positioned to comprehend carcinogenesis at a molecular level in greater detail due to significant technological advancements. Additionally, we are now able to rationally design and develop drug molecules with the ability to either selectively enhance or disrupt important biological processes, maximizing their therapeutic potential. This has heralded a new era in drug design. The heterometallic ruthenium–platinum complexes can be used as anticancer, photodynamic therapy, diabetes treatment, and molecular sensors for thiol-containing peptides due to their multifunctional interactions with nuclear DNA, mitochondrial DNA, RNA, and proteins. Compared to cisplatin and its Ru-based monometallic precursors, a significant number of reported ruthenium–platinum complexes exhibit enhanced cytotoxicity and tumor selectivity. Due to the covalent binding of the cis-PtIICl2 moiety to DNA, photoactive Ru(II)–Pt(II) complexes were designed to prelocalize a photodynamic therapy agent at the site of action. The development of ruthenium–platinum-based heterometallic complexes has recently advanced, opening up new avenues for the development of drugs that are more efficient. Metal complexes’ potential as important cancer therapeutic agents will be the primary focus of this review. The development of ruthenium and platinum-based mono and mixed-metal complexes with therapeutic and biomedical applications are discussed in detail in this article.
Performances colaborativas ou como produzir teorias no movimento
Authors: Blanca Rosa Maria 
Published: May 2023

O artigo pesquisa o convívio e a amizade como formas da subjetividade da produção da arte contemporânea, e seus atravessamentos com a ar te do queer e feminista, discutindo categorias como espaço seguro, trabalho colaborativo, performances colaborativas, identidade coletiva, écharpe queer e teoria em deslocamento. Desenvolve uma genealogia das práticas colaborativas e feministas. Estudam-se projetos coletivos como AIR -Ar tists in Residence-, Womanhouse do Programa Feminista de Ar te do Instituto de Ar te da Califórnia, Guerrilla Girls, COLAB, Fashion Moda e ACT-UP (AIDS Coalition to Unleash Power), para finalmente tencionar a performance colaborativa do Coño Insumiso, realizada no âmbito do congresso 13ª Marcha Mundial das Mulheres e do 11º Seminário Internacional Fazendo Gênero, em Florianópolis, Brasil, em 2017, em solidariedade internacional à performance andaluza do Sagrado Coño Insumiso realizada no contexto espanhol, em 2014.Palavras-chave: Arte feminista e queer; Amizade; Convívio; Solidariedade internacional; Subjetividades Colaborative Performances or How to Produce Theories in MovementAbstract: The article researches conviviality and friendship as forms of subjectivity in the production of contemporary art, and its crossings with queer and feminist art, discussing categories such as safe space, collaborative work, collaborative performances, collective identity, écharpe queer and theory in displacement. It develops a genealogy of collaborative and feminist practices. Collective projects such as AIR -Artists in Residence-, Womanhouse from the Feminist Art Program of the California Institute of Art, Guerrilla Girls, COLAB, Fashion Moda and ACT-UP (AIDS Coalition to Unleash Power) are studied to finally intend the performance collaborative ef fort by Coño Insumiso, held within the scope of the 13th World March of Women congress and the 11th International Seminar Doing Gender, in Florianópolis, Brazil, in 2017, in international solidarity with the Andalusian performance of Sagrado Coño Insumiso held in the Spanish context, in 2014. Keywords: Feminist and queer art; Friendship; Conviviality; International solidarity; Subjectivities
"CO": prefixo latino que traz consigo o sentido de "com"
Authors: Biancalana Gisela Reis 
Published: May 2023

O trabalho aponta os desafios da criação COnjunta e apresenta duas performances artísticas, Aqui ou AliXo e Rubra Fluidez, desenvolvidas por integrantes do Laboratório de Pesquisa em Performance Arte e Cultura (LAPARC/ UFSM). Ao discutir as práticas de colaboração e entrecruzamentos de saberes, ou seja, “saberes-fazeres advindos das experiências conjuntas”, desenvolve o pensamento sobre o termo colaboração em artes e o modo de fazer arte junto, debruçando-se nas considerações do norueguês Florian Schneider, da boliviana Maria Galindo, entre outros, assim como a evidência de outros termos que versam sobre a produção artísticas com autoria compartilhada.Palavras-chave: Criação COnjunta; Performance; Colaboração; autoria. “CO”: Latin Prefix that carries a sense of “WITH” Abstract: The work points to the challenges of joint creation and presents two artistic performances, Aqui ou AliXo and Rubra Fluidez, developed by members of the Research Laboratory in Performance Art and Culture (LAPARC of the Federal University of Santa Maria/UFSM, Brazil). When discussing the practices of collaboration and knowledge intersections, which is “[the] know-how arising from joint experiences”, the paper ref lects on the term ‘collaboration in the arts’ and ways of making art together, considering Norwegian author Florian Schneider and Bolivian Maria Galindo, among others, as well as other terms that deal with artistic production with shared authorship.Keywords: CO; Joint creation; Performance; Collaboration; authorship.
Intervenções urbanas: o processo criativo no contexto artístico contemporâneo
Authors: Hildebrand Hermes Renato , Silva Gil Adeline Gabriela , De Araújo Daniel Paz 
Published: May 2023

Pretende-se investigar as condições criativas que se realizam por meio das artes interativas e contemporâneas, no contexto da complexidade, interação, colaboração e com base nas tecnologias emergentes. Ao acompanhar o processo criativo de vários projetos de intervenções urbanas, busca-se levantar dados, para mapear e cartografar territórios que se vinculam às práticas artísticas, de entretenimento e de gestão pública, enfatizando as emergências de padrões estéticos, poéticos e diferentes formas de significação por meio das narrativas digitais. Serão analisadas três intervenções artísticas: Air City: arte#ocupaSM-2012-2013, realizada em Santa Maria – RS, ZL Vórtice, na Zona Leste da cidade de São Paulo – SP e ParaTy - Trilha dos Sete Degraus, na cidade de Paraty – RJ, todas no Brasil. As obras artísticas foram analisadas com base no “Método Cartográfico”, criado por Gilles Deleuze e Félix Guattari (1995) que abordam as dimensões da subjetividade, criatividade e elaboração do conhecimento. Acredita-se que a “desprogramação de processos” por meio da incorporação do imprevisível, apresenta componentes estéticos e poéticos que podem ser destacados ao observarmos os aspectos que compõem estas intervenções.Palavras-chave: Complexidade; cartografia; arte contemporânea; processos de criação; método cartográfico. Urban Interventions: Creative process in the context of contemporary artAbstract: The aim is to investigate the creative conditions which occur through interactive and contemporary arts, in the context of complexity, interaction, collaboration and based on emerging technologies. As we follow the creative process of various urban interventions projects, we seek to collect data to map and [cartographically] map territories that are linked to artistic, entertainment and public management practices, emphasizing the emergence of aesthetic, poetic and differing forms of meaning in digital narratives. Three artistic interventions presented in Brazil will be analyzed: Air City: arte#ocupa-SM/2012-2013, in the city of Santa Maria – RS, ZL Vórtice in the East Zone of the city of São Paulo, SP and ParaTy-Trilha dos Sete Degraus, in the city of Paraty, RJ. The art works were elaborated based on the "Cartographic Method", created by Gilles Deleuze and Félix Guattari (1995) that approach the dimensions of subjectivity, creativity and knowledge elaboration. It is believed that the "deprogramming of processes" through the incorporation of the unpredictable presents aesthetic and poetic components which may be highlighted by observing the aspects that make up these interventions. Keywords: Complexity; Cartography; Contemporary art; Creative processes; Cartographic method.
CENTRO COMPACTO DE DEVANEIO CIDADE – RIO. A casa da avó como espaço alternativo na arte contemporânea
Authors: Meireles Nauita Martins 
Published: May 2023

O artigo aborda a pesquisa e a produção poética realizada em coautoria com a artista Anieli Martins, cocriadora do Centro Compacto de Devaneio: laboratório poético, localizado na cidade de Pedro Osório-RS. Discuto os encontros com os moradores e as experiências no Centro e em outros lugares da cidade, como a elaboração e distribuição de impressos múltiplos, panfletos, adesivos e a ação Propagandeando Poesia, realizada com uma bicicleta sonora. A instauração deste lugar e de suas ações levanta questões relativas à cidade de Pedro Osório, suas especificidades geográficas e sua condição de região atravessada pelo rio Piratini, que seguidamente transborda. Evidenciamos os laços com uma arte que se realiza em contexto real, no espaço urbano e em situações existentes. O desenvolvimento de minha produção poética emerge da relação estabelecida - junto a Anieli - com a cidade, o rio, as pessoas e as memórias. Levantamos como essa produção inserida em seu corpo social e em locais específicos também possa ser apresentada em outros locais (como galerias), com o interesse de ativar o rio e sua potência de transbordar história e marcas sensíveis.Palavras-chave: Centro Compacto de Devaneio; Rio Piratini; Arte Contextual. COMPACT DAYDREAMING CENTER City - River Grandma’s House as an Alternative Space for Contemporary ArtAbstract: This article addresses the research and poetic production carried out in co-authorship with the artist Anieli Martins, co-creator of the Compact Center of City Daydreaming: a poetic laboratory, located in the city of Pedro Osório, Rio Grande do Sul (RS), Brazil. I discuss the meetings with residents and the experiences at the Center and actions at other urban locations, such as the elaboration and distribution of multiples, printed matter, stickers and the action Propaganding Poetry, performed using a sonorous bicycle. The establishment of this Center and its actions raises questions related to the city of Pedro Osório, its geographical specificities and its condition as a region crossed through by the Piratini River, which often overflows. We highlight the ties with an art that takes place in a real context, in urban space and in existing situations. The development of my poetic production emerges from the relationship established - together with Anieli - with the city, the river, people and memories. We raise the question of this production inserted in its social body and in specific places, also being presented in other places (such as galleries), with the interest of activating the river and its power to overflow history and sensitive signs.Keywords: Compact Daydream Center; Piratini River; Contextual Art.
Energetic landscape of polycystin channel gating
Authors: Ng Leo CT , Harris Brandon J , Larmore Megan , Ta My C , Vien Thuy N , Tokars Valerie L , Yarov‐Yarovoy Vladimir , DeCaen Paul G 
Published: May 2023

AbstractMembers of the polycystin family (PKD2 and PKD2L1) of transient receptor potential (TRP) channels conduct Ca2+ and depolarizing monovalent cations. Variants in PKD2 cause autosomal dominant polycystic kidney disease (ADPKD) in humans, whereas loss of PKD2L1 expression causes seizure susceptibility in mice. Understanding structural and functional regulation of these channels will provide the basis for interpreting their molecular dysregulation in disease states. However, the complete structures of polycystins are unresolved, as are the conformational changes regulating their conductive states. To provide a holistic understanding of the polycystin gating cycle, we use computational prediction tools to model missing PKD2L1 structural motifs and evaluate more than 150 mutations in an unbiased mutagenic functional screen of the entire pore module. Our results provide an energetic landscape of the polycystin pore, which enumerates gating sensitive sites and interactions required for opening, inactivation, and subsequent desensitization. These findings identify the external pore helices and specific cross‐domain interactions as critical structural regulators controlling the polycystin ion channel conductive and nonconductive states.
Transcription factor expression is the main determinant of variability in gene co‐activity
Authors: van Duin Lucas , Krautz Robert , Rennie Sarah , Andersson Robin 
Published: May 2023

AbstractMany genes are co‐expressed and form genomic domains of coordinated gene activity. However, the regulatory determinants of domain co‐activity remain unclear. Here, we leverage human individual variation in gene expression to characterize the co‐regulatory processes underlying domain co‐activity and systematically quantify their effect sizes. We employ transcriptional decomposition to extract from RNA expression data an expression component related to co‐activity revealed by genomic positioning. This strategy reveals close to 1,500 co‐activity domains, covering most expressed genes, of which the large majority are invariable across individuals. Focusing specifically on domains with high variability in co‐activity reveals that contained genes have a higher sharing of eQTLs, a higher variability in enhancer interactions, and an enrichment of binding by variably expressed transcription factors, compared to genes within non‐variable domains. Through careful quantification of the relative contributions of regulatory processes underlying co‐activity, we find transcription factor expression levels to be the main determinant of gene co‐activity. Our results indicate that distal trans effects contribute more than local genetic variation to individual variation in co‐activity domains.