bluuebunny/crossref_metadata_2025_split huggingface dataset:
LITERATURE REVIEW GAMBARAN TERAPI PLASSMA KONVALESEN UNTUK PASIEN COVID-19
Authors: Supadmi Francisca Romana Sri , Sinaga Yossi Pramita , Yuni Astuti Tyas Ning 
Published: May 2023

Latar belakang COVID-19 merupakan penyakit yang disebabkan oleh Severa Acute Respiratory Syndrome Coronavirus2 (SARS-CoV-2). SARS-CoV-2 memiliki laju mutasi yang tinggi sehingga karakteristik virus berubah-ubah menyebabkan virus yang sama memiliki sifat baru. Terapi plasma konvalesen (PK) merupakan terapi dengan menggunakan plasma yang berasal dari pasien COVID-19 yang telah pulih. Hasil dari pelaksanaan terapi PK sangat dipengaruhi oleh produk terapi yang digunakan dan kriteria pasien yang menerima terapi PK. Sehingga peneliti ingin mengetahi gambaran terapi PK untuk pasien COVID-19 dengan studi literature review. Tujuan: untuk mengetahui gambaran terapi plasma konvalesen untuk pasien COVID-19. Metode penelitian literature review. Hasil Penelitian: Terdapat perbedaan dan persamaan pada kriteria pendonor PK dan pasien penerima PK dari jurnal. Sedangkan pada hasil pemberian PK dari jurnal menunjukan hasil yang sama. Kesimpulan: Kriteria pendonor PK yaitu pasien COVID-19 yang telah pulih, tidak muncul gejala selama 14 hari, , negative antibody HLA, memiliki antibody IgG dan IgM terhadap SARS-CoV-2, serta memenuhi syarat standar donor darah. Kriteria pasien penerima PK yaitu pasien COVID-19 yang memiliki gejala berat dan mengancam jiwa, IgA normal, GCS ?12, GFR ?30, dan tidak ada hipertensi tidak terkendali. Serta, hasil dari pemberian PK menunjukan perbaikan gejala klinis dan angka kematian yang lebih kecil pada pasien penerima PK.
Gambaran tingkat kepuasan pasien terhadap pelayanan kefarmasian pada era globalisasi di klinik utama “X” Kota Semarang.
Authors: WS FX Sulistiyanto , Anggoro Aloysius Barry , . Erwin Indriyanti 
Published: May 2023

Pharmaceutical services are the main support in every health facility and are part of health services that aim to increase the rational, safe and efficient use of drugs in order to achieve an increase in the quality of human life. Efforts to improve pharmacy services in the main clinic need to be accompanied by an evaluation of the level of satisfaction. Consumer satisfaction is a response to every service received and is an important part because patient satisfaction cannot be separated from the quality of health services. The purpose of this study was to determine the characteristics of patients based on gender, age, last education and occupation. Then to determine the level of patient satisfaction with pharmaceutical services. The method used in this research is descriptive method with a quantitative approach. Data analysis uses percentages and a Likert scale. The population in this study were outpatients who received pharmacy services at the main clinical pharmacy installation "X" Semarang City. The results of the characteristic study showed that 80% of the respondents were female. Based on the age of the respondents who visited the most were aged 26 - 35 years (33.1%), and the least were aged 56 - 65 years (7.4%). The majority of respondents have high school education (42.3%). Most of the respondents' occupational data in this study were other (60%), dominated by housewives. The frequency of visits (71.4%) of respondents visited more than 2 times and 28.6% of respondents visited 2 times. The average result of patient satisfaction based on five dimensions obtained a value of 3.04 with a satisfied statement. Keywords: Pharmaceutical services, ServQual, satisfaction, primary clinics
PENGARUH PEMBERIAN KONSELING GIZI TERHADAP PEMILIHAN MAKAN PADA REMAJA PUTRI OVERWEIGHT DAN OBESITAS
Authors: Maulidiyah Putri , Kurniasari Ratih 
Published: May 2023

In Indonesia there are still many adolescents who experience multiple nutritional problems caused by the increasing number of population with more nutritional status, one of which is overweight. One of the causes of overweight is because of food selection. Food choices can be influenced by family eating habits, advertisements in various media, peers, and the environment. Nutrition counseling is a form of approach that aims to help clients/respondents identify and analyze problems with clients and provide alternative solutions to problems. The purpose of this study was to see the effect of providing nutritional counseling on food choices in overweight female adolescents. The method used in this research is literature review by collecting research journals or reviewing articles by searching the database using Google Scholar as many as 4 journals spanning 2017-2022. In this study, the provision of nutritional counseling can influence and change the choice of food for young women, who initially chose random food to choose good and healthy food. Keywords: nutrition counseling; overweight; youth; food
PERBEDAAN MENTAL HEALTH REMAJA PADA SMA NEGERI 3 DAN SMA MATARAM BERBASIS STRENGHT AND DIFFICULTIES QUESTIONNAIRE (SDQ) DI KOTA SEMARANG
Authors: Muthoharoh Nor Amalia , Setyawati Vilda Ana Veria , Aprianti Aprianti , Anggraini Fitria Dewi Puspita 
Published: May 2023

The Covid-19 pandemic in recent years has been a global crisis and a non-natural disaster which has had a profound impact on all sectors of life, not only threatening people's physical health, but can also have an impact on mental and social health. Very significant changes like this can cause some negative responses such as fatigue, discomfort and anxiety.Adolescence is a period said to be a period of adolescent transition from childhood to adulthood. Many individuals who are in their teenage years will usually experience significant changes both physically, socially and psychologically in adolescence. Conditions like this are very disturbing mentally for adolescents, where adolescents feel uncomfortable, easily get emotional with their environment if it doesn't suit their wishes, the influence of geekjet also plays an important role in the emotional condition of adolescents. According to WHO lately the number of depression in adolescents shows that 80-90% of adolescents experience depression to the point of suicide, one of the causes of teenage depression is due to bullying, and emotions due to social media.This research focuses on early planning related to mental health in adolescents through initial screening using the SDQ as a movement effort to reduce the number of mental health disorders. Mental health is very important in supporting the productivity and quality of physical health in adolescents because where adolescence is a golden period in its development, it is expected that adolescents can manage stress and anxiety in themselves.Keywords: Mental, Health and Adolescent
Studi Literatur ; Terapi Emotional Freedom Technique (EFT) Terhadap Penurunan Ansietas Pasien Pre Operasi
Authors: Malaha Anniza Febriani , Suharto Dewi Nurviana , Nilasanti Ni Made Ridla , Manggasa Dafrosia Darmi 
Published: May 2023

Tindakan pembedahan merupakan salah satu tindakan medis yang akan mendatangkan stresor terhadap integritas seseorang. Reaksi yang muncul berupa reaksi stres baik fisiologis maupun psikologis akan tetapi yang paling menonjol adalah reaksi secara psikologis berupa kecemasan. Salah satu cara mudah dan sederhana yang dapat dilakukan untuk mengurangi kecemasan adalah dengan memberikan terapi Emotional Freedom Technique (EFT). Tujuan : mengidentifikasi studi literature yang berhubungan dengan Terapi Emotional Freedom Technique (EFT) Terhadap Penurunan Ansietas Pasien Dengan Pre Operasi Mayor. Metode : basis data yang digunakan dalam studi literatur yaitu Publish Or Perish, Google Scholar, dan Google terbatas dari tahun 2015-2020. Hasil : ada 5 artikel yang digunakan dalam penelitian, dari kelima artikel didapatkan hasil bahwa Emotional Freedom Technique (EFT) memiliki pengaruh terhadap tingkat kecemasan pasien pre operasi. Kesimpulan : TerapiEmotional Freedom Technique (EFT) mempunyai pengaruh yang signifikan terhadap penurunan tingkat kecemasan pasien pre operasi. Saran : Diharapkan hasil penelitian ini bisa menambah pengetahuan dan wawasan peneliti selanjutnya tentang intervensi keperawatan yang dapat digunakan dalam kecemasan pada pasien pre operasi.
Constraining the Geochemical Fingerprints of Gases from the UK Carboniferous Coal Measures at the Glasgow Geoenergy Observatories Field Site, Scotland
Authors: Chambers Rebecca M. , Johnson Gareth , Boyce Adrian J. , Gilfillan Stuart M. V. 
Published: May 2023

Usage of thermal energy contained in abandoned, flooded, coal mines has the potential to contribute to low carbon heating or cooling supply and assist in meeting net-zero carbon emission targets. However, hazardous ground gases, such as CH
4
and CO
2
, can be found naturally in superficial deposits, coal bearing strata and abandoned mines. Determining the presence, magnitude, and origin of subsurface gases, and how their geochemical fingerprints evolve within the shallow subsurface is vital to developing an understanding of how to manage the risk posed by ground gases in geoenergy technology development. Here, we present the first CH
4
and CO
2
concentration-depth profiles and stable isotope (δ
13
C
CH4
, δ
13
C
CO2
, and δD
CH4
) profiles obtained from UK mine workings, through analysis of headspace gas samples degassed from cores and chippings collected during construction of the Glasgow Observatory. These are used to investigate the variability of gas fingerprints with depth within unmined Carboniferous coal measures and Glasgow coal mine workings. Stable isotope compositions of CH
4
(δ
13
C
CH4
= −73.4‰ to −14.3‰; δ
13
C
CO2
= −29‰ to −6.1‰; δD
CH4
= −277‰ to −88‰) provide evidence of a biogenic source, with carbonate reduction being the primary pathway of CH
4
production. Gas samples collected at depths of 63–79 m exhibit enrichments in 13C
CH4
and
2
H, indicating the oxidative consumption of CH
4
. This correlates with their proximity to the Glasgow Ell mine workings, which will have increased exposure to O
2
from the atmosphere as a result of mining activities. CO
2
gas is more abundant than CH
4
throughout the succession in all three boreholes, exhibiting high δ
13
C
CO2
values relative to the CH
4
present. Gases from unmined bedrock exhibit the highest δ
13
C
CO2
values, with samples from near-surface superficial deposits having the lowest δ
13
C
CO2
values. δ
13
C
CO2
values become progressively lower at shallower depths (above 90 m), which can be explained by the increasing influence of shallow groundwaters containing a mixture of dissolved marine carbonate minerals (∼0‰) and soil gas CO
2
(−26‰) as depth decreases. Our findings provide an insight into the variability of mine derived gases within 200 m of the surface, providing an important ‘time-zero’ record of the site, which is required in the design of monitoring approaches.
Bioinformatics analysis of aging-related genes in thoracic aortic aneurysm and dissection
Authors: Wan Hong , Liu Danlingyi , Liu Bingqing , Sha Mengyao , Xia Wei , Liu Chang 
Published: May 2023

ObjectiveThoracic aortic aneurysm and dissection (TAAD) is a cardiovascular disease with a high mortality rate. Aging is an important risk factor for TAAD. This study explored the relationship between aging and TAAD and investigated the underlying mechanisms, which may contribute to the diagnosis and treatment of TAAD.MethodsHuman aging genes were obtained from the Aging Atlas official website. Various datasets were downloaded from the GEO database:the human TAAD dataset GSE52093 were used for screening differentially expressed genes (DEGs); GSE137869, GSE102397 and GSE153434 were used as validation sets, and GSE9106 was used for diagnostic prediction of receiver operating characteristic (ROC) curves. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and protein–protein interaction (PPI) network analysis were used to screen differentially co-expressed genes from human aging genes and TAAD. Using five methods of the cytoHubba plugin in Cytoscape software (Degree, Closeness, EPC, MNC, Radiality), hub genes were identified from the differentially co-expressed genes. Single-cell RNA sequencing was used to verify the expression levels of hubgenes in different cell types of aortic tissue. ROC curves were used to further screen for diagnostic genes.ResultsA total of 70 differentially co-expressed genes were screened from human aging genes and DEGs in human TAAD dataset GSE52093. GO enrichment analysis revealed that the DEGs played a major role in regulating DNA metabolism and damaged DNA binding. KEGG enrichment analysis revealed enrichment in the longevity regulating pathway, cellular senescence, and HIF-1 signaling pathway. GSEA indicated that the DEGs were concentrated in the cell cycle and aging-related p53 signaling pathway. The five identified hubgenes were MYC, IL6, HIF1A, ESR1, and PTGS2. Single-cell sequencing of the aging rat aorta showed that hubgenes were expressed differently in different types of cells in aortic tissue. Among these five hubgenes, HIF1A and PTGS2 were validated in the aging dataset GSE102397; MYC, HIF1A and ESR1 were validated in the TAAD dataset GSE153434. The combined area under the diagnostic ROC curve (AUC) values for the five hub genes were &gt;0.7 in the testing and training sets of the dataset GSE9106. The combined AUC values of MYC and ESR1 were equal to the combin ed AUC values of the five hub genes.ConclusionThe HIF-1 signaling pathway may play an important role in TAAD and aging. MYC and ESR1 may have diagnostic value for aging-related TAAD.
Using Mendelian randomization analysis to determine the causal connection between unpleasant emotions and coronary atherosclerosis
Authors: Lei Jiyong , Luo Da , Xiong Jiarui , Li Mingjiang 
Published: May 2023

ObjectiveObservational studies have shown a correlation between unpleasant emotions and coronary atherosclerosis, but the underlying causal linkages are still uncertain. We conducted a Mendelian randomization (MR) investigation on two samples for this purpose.MethodsIn genome-wide association studies in the UK Biobank (total = 459,561), we selected 40 distinct single-nucleotide polymorphisms (SNPs) related to unpleasant emotions as genome-wide statistically significant instrumental variables. FinnGen consortium provided summary-level data on coronary atherosclerosis for 211,203 individuals of Finnish descent. MR-Egger regression, the inverse variance weighted technique (IVW), and the weighted median method were used in the process of conducting data analysis.ResultsThere was sufficient evidence to establish a causal connection between unpleasant emotions and coronary atherosclerosis risk. For each unit increase in the log-odds ratio of unpleasant feelings, the odds ratios were 3.61 (95% CI: 1.64–7.95; P = 0.001). The outcomes of sensitivity analyses were comparable. There was no indication of heterogeneity or directional pleiotropy.ConclusionOur findings provide causal evidence for the effects of unpleasant emotions on coronary atherosclerosis.
The feasibility and safety of his-purkinje conduction system pacing in patients with heart failure with severely reduced ejection fraction
Authors: Ma Chengming , Wang Zhongzhen , Ma Zhulin , Ma Peipei , Dai Shiyu , Wang Nan , Yang Yiheng , Li Guocao , Gao Lianjun , Xia Yunlong , Xiao Xianjie , Dong Yingxue 
Published: May 2023

ObjectiveThe purpose of this study was to evaluate the feasibility and outcomes of conduction system pacing (CSP) in patients with heart failure (HF) who had a severely reduced left ventricular ejection fraction (LVEF) of less than 30% (HFsrEF).MethodsBetween January 2018 and December 2020, all consecutive HF patients with LVEF &lt; 30% who underwent CSP at our center were evaluated. Clinical outcomes and echocardiographic data [LVEF and left ventricular end-systolic volume (LVESV)], and complications were all recorded. In addition, clinical and echocardiographic (≥5% improvement in LVEF or ≥15% decrease in LVESV) responses were assessed. The patients were classified into a complete left bundle branch block (CLBBB) morphology group and a non-CLBBB morphology group according to the baseline QRS configuration.ResultsSeventy patients (66 ± 8.84 years; 55.7% male) with a mean LVEF of 23.2 ± 3.23%, LVEDd of 67.33 ± 7.47 mm and LVESV of 212.08 ± 39.74 ml were included. QRS configuration at baseline was CLBBB in 67.1% (47/70) of patients and non-CLBBB in 32.9%. At implantation, the CSP threshold was 0.6 ± 0.3 V @ 0.4 ms and remained stable during a mean follow-up of 23.43 ± 11.44 months. CSP resulted in significant LVEF improvement from 23.2 ± 3.23% to 34.93 ± 10.34% (P &lt; 0.001) and significant QRS narrowing from 154.99 ± 34.42 to 130.81 ± 25.18 ms (P &lt; 0.001). Clinical and echocardiographic responses were observed in 91.4% (64/70) and 77.1% (54/70) of patients. Super-response to CSP (≥15% improvement in LVEF or ≥30% decrease in LVESV) was observed in 52.9% (37/70) of patients. One patient died due to acute HF and following severe metabolic disorders. Baseline BNP (odds ratio: 0.969; 95% confidence interval: 0.939–0.989; P = 0.045) was associated with echocardiographic response. The proportions of clinical and echocardiographic responses in the CLBBB group were higher than those in the non-CLBBB group but without significant statistical differences.ConclusionsCSP is feasible and safe in patients with HFsrEF. CSP is associated with a significant improvement in clinical and echocardiographic outcomes, even for patients with non-CLBBB widened QRS.
Characteristics of out-of-hospital cardiac arrest patients in Riyadh province, Saudi Arabia: a cross-sectional study
Authors: Almiro Alyaman , AlQassab Osamah , Alzeidan Rasmieh , Binhaddab Abdulaziz Saad , Alkhorisi Ahmad M. , Almalki Hani A , Ghouthalsayd Muhannad Abdulaziz , Kashour Tarek , Hersi Ahmed , Alqarawi Wael 
Published: May 2023

IntroductionLittle work has been done on out-of-hospital cardiac arrest (OHCA) in Saudi Arabia. Our goal is to report the characteristics of OHCA patients and predictors of bystander cardiopulmonary resuscitation (CPR).Materials and methodsThis cross-sectional study utilized data from the Saudi Red Crescent Authority (SRCA), a governmental emergency medical service (EMS). A standardized data collection form based on the “Utstein-style” guidelines was developed. Data were retrieved from the electronic patient care reports that SRCA providers fill out for every case. OHCA cases that were attended by SRCA in Riyadh province between June 1st, 2020 and May 31st, 2021 were included. Multivariate regression analysis was performed to assess independent predictors of bystander CPR.ResultsA total of 1,023 OHCA cases were included. The mean age was 57.2 (±22.6). 95.7% (979/1,023) of cases were adults and 65.2% (667/1,023) were males. Home was the most common location of OHCA [784/1,011 (77.5%)]. The initial recorded rhythm was shockable in 131/742 (17.7%). The EMS mean response time was 15.9 min (±11.1). Bystander CPR was performed in 130/1,023 (12.7%) and was more commonly performed in children as compared to adults [12/44 (27.3%) vs. 118/979 (12.1%), p = 0.003]. Independent predictors of bystander CPR were being a child (OR = 3.26, 95% CI [1.21–8.82], p = 0.02) and having OHCA in a healthcare institution (OR = 6.35, 95% CI [2.15–18.72], p = 0.001).ConclusionOur study reported the characteristics of OHCA cases in Saudi Arabia using EMS data. We observed young age at presentation, low rates of bystander CPR, and long response time. These characteristics are distinctly different from other countries and call for urgent attention to OHCA care in Saudi Arabia. Lastly, being a child and having OHCA in a healthcare institution were found to be independent predictors of bystander CPR.
Could METS-VF provide a clue as to the formation of kidney stones?
Authors: Guo Zhenyu , Li Guoxiang , Chen Yan , Fan Shuai , Sun Shuai , Hao Yunwu , Wang Wei 
Published: May 2023

ObjectiveThe lifetime occurrence rate of kidney stones is 14%, making it one of the most prevalent urological conditions. Other contributing elements, such as obesity, diabetes, diet, and heredity, are also taken into account. Our research sought to explore the potential link between high visceral fat scores (METS-VF) and the occurrence of kidney stones, as a means of understanding how to prevent them.MethodsThis research utilized data from the National Health and Nutrition Examination Survey (NHANES), mirroring the demographics of the United States. We carried out an in-depth analysis of the connection between METS-VF and kidney stones, based on data from 29,246 participants in the National Health and Nutrition Examination Survey spanning 2007 to 2018, involving logistic regression, segmentation, and dose-response curve analysis.ResultsOur study of 29,246 potential participants found that METS-VF was positively associated with the prevalence and progression of kidney stones. After subgroup analysis by gender, race, blood pressure, and blood glucose, our results showed that the ORs for METS-VF and kidney stones were (1.49, 1.44) in males and females, respectively; while in Mexicans, whites, blacks, and In other populations, the OR values were (1.33, 1.43, 1.54, 1.86); in hypertensive and normal populations, the OR values were (1.23, 1.48); in diabetic patients and normoglycemic patients were (1.36,1.43). This proves that it works for all groups of people.SummaryOur studies demonstrate a strong connection between METS-FV and the emergence of kidney stones. It would be beneficial to investigate METS-VF as a marker for kidney stone development and progression in light of these findings.
Serum fibroblast growth factor 1 and its association with pancreatic beta cell function and insulin sensitivity in adults with glucose intolerance
Authors: Kim Ji Yoon , Choi Jimi , Kwon Yeongkeun , Park Sungsoo , Kim Sin Gon , Kim Nam Hoon 
Published: May 2023

BackgroundBeneficial role of fibroblast growth factor 1 (FGF1) in the regulation of glucose metabolism and adipose tissue remodeling was suggested in rodents. This study aimed to investigate the association between serum FGF1 levels and metabolic parameters in adults with glucose intolerance.MethodsSerum FGF1 levels were examined using an enzyme-linked immunosorbent assay in 153 individuals with glucose intolerance. Associations between serum FGF1 levels and metabolic parameters, including body mass index (BMI), glycated hemoglobin (HbA1c), and 75 g oral glucose tolerance test-derived parameters, including insulinogenic index (IGI), Matsuda insulin sensitivity index (ISI), and disposition index (DI), were examined.ResultsSerum FGF1 was detected in 35 individuals (22.9%), possibly due to the autocrine/paracrine nature of the peptide. IGI and DI levels were significantly lower in individuals with higher FGF1 levels than in those with lower FGF1 levels or undetectable FGF1 (p=0.006 and 0.005 for IGI and DI, respectively, after adjustment for age, sex, and BMI). Univariable and multivariable analyses using the Tobit regression model also revealed a negative association between FGF1 levels and IGI and DI. The regression coefficients per 1-SD of log-transformed IGI and DI were −0.461 (p=0.013) and −0.467 (p=0.012), respectively, after adjustment for age, sex, and BMI. In contrast, serum FGF1 levels were not significantly associated with ISI, BMI, or HbA1c.ConclusionsThe serum concentration of FGF1 was significantly elevated in individuals with low insulin secretion, suggesting a possible interaction between FGF1 and beta cell function in humans.