bluuebunny/crossref_metadata_2025_split huggingface dataset:
GKL‐finite‐time stability via comparison principles for stochastic impulsive systems
Authors: Xiao Pan , Liu Bin , Tang Qiong , Sun Zhijie 
Published: July 2023

AbstractThis paper studies the finite‐time stability (FTS) for stochastic impulsive systems (SIS). The notions of FTS including
‐FTS and event‐
‐FTS are proposed for SIS. The comparison principles for
‐FTS and event‐
‐FTS are established, respectively. Then the FTS criteria with the settling time estimates are derived. The criteria of
‐FTS and event‐
‐FTS relax the requirements on stabilizing flow and jump for FTS in the literature. Finally, two examples are presented to demonstrate the obtained results.
Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti‐inflammation capacity
Authors: Han Yongli , Luo Lingling , Li Hongli , Zhang Lijun , Yan Yingxuan , Fang Minglv , Yu Jing , Gao Xiaoyan , Liu Ying , Huang Cheng , Fan Shengjie 
Published: July 2023

AbstractNonalcoholic steatohepatitis (NASH) and hepatic fibrosis are leading causes of cirrhosis with rising morbidity and mortality worldwide. Currently, there is no appropriate treatment for NASH and hepatic fibrosis. Many studies have shown that oxidative stress is a main factor inducing NASH. Nomilin (NML) and obacunone (OBA) are limonoid compounds naturally occurring in citrus fruits with various biological properties. However, whether OBA and NML have beneficial effects on NASH remains unclear. Here, we demonstrated that OBA and NML inhibited hepatic tissue necrosis, inflammatory infiltration and liver fibrosis progression in methionine and choline‐deficient (MCD) diet, carbon tetrachloride (CCl4)‐treated and bile duct ligation (BDL) NASH and hepatic fibrosis mouse models. Mechanistic studies showed that NML and OBA enhanced anti‐oxidative effects, including reduction of malondialdehyde (MDA) level, increase of catalase (CAT) activity and the gene expression of glutathione S‐transferases (GSTs) and Nrf2‐keap1 signaling. Additional, NML and OBA inhibited the expression of inflammatory gene interleukin 6 (Il‐6), and regulated the bile acid metabolism genes Cyp3a11, Cyp7a1, multidrug resistance‐associated protein 3 (Mrp3). Overall, these findings indicate that NML and OBA may alleviate NASH and liver fibrosis in mice via enhancing antioxidant and anti‐inflammation capacity. Our study proposed that NML and OBA may be potential strategies for NASH treatment.
Structure of the perception of health professionals regarding the quality of health services in the context of COVID‐19
Authors: Vega‐Dienstmaier Johann M. , Fernández‐Arana Alberto , Olórtegui‐Yzú Adriel 
Published: July 2023

AbstractBackgroundThe health emergency caused by COVID‐19 revealed the shortcomings of health services (HS), but little is known about how this has impacted the mental health of health professionals (HP) when perceiving these difficulties.MethodsData were collected through an online survey administered to HP in Lima (Peru) between May and July 2020. A questionnaire was applied to identify perceived quality of health services (PHQS). A network analysis was performed, and the centrality measures of the variables were calculated and plotted.ResultsA total of 507 HP completed the survey. In the network analysis of PHQS, four clusters were identified: (A) “empathy” and “recognition of competencies,” (B) “logistical support,” “protection,” “personal early diagnosis,” and “early family diagnosis”; C) “professional competence with regard to their treatment and treatment for their family,” “equipment for their treatment and treatment for their family,” “professional competence with regard to their treatment and treatment for their family,” and “institutional support for them and their family”; and D) “fear of being infected or infecting their family,” “fear of dying or death of a family member,” “knowledge stability,” “job burnout,” and “role change.” The variables of PHQS with the greatest centrality were “equipment for their treatment,” “equipment for the treatment of their family,” and “early family diagnosis.”ConclusionsThe structure of the PHQS of HP describes direct and indirect influences of different variables in the context of COVID‐19.
Navigating circular economy: Unleashing the potential of political and supply chain analytics skills among top supply chain executives for environmental orientation, regenerative supply chain practices, and supply chain viability
Authors: Bag Surajit , Rahman Muhammad Sabbir 
Published: July 2023

AbstractIn a changing business environment, firms encounter significant challenges to fulfill sustainable development goals. However, firms can make substantial progress by adopting regenerative approaches grounded in circular economy principles, enabling them to effectively pursue sustainable development objectives such as responsible production and consumption (goal 12), climate action (goal 13), and the preservation of life on land (goal 15). However, there is a scarcity of research studies that offer guidance to top supply chain (SC) executives, aiming to enhance their environmental focus and enhance the SC viability through regenerative SC practices. This study employed the philosophical perspective of the natural resource‐based view. Advancing the SC literature, it tested a theoretical model to investigate the relationship between the political skills and SC analytics skills of top SC executives and the environmental orientation of SCs. Additionally, it examined the direct and indirect (via regenerative SC) relationships between a firm's environmental orientation and SC viability. This study also tested the moderating role of a firm's artificial intelligence‐driven big data analytics culture in these relationships. Applying a mixed‐methods approach, the study derived a theoretical model to link the aforementioned constructs. Apart from a qualitative investigation, data were also collected through a questionnaire‐based survey from 375 samples. The results indicated that the relationship between the political skills and SC analytics skills of top SC executives toward the environmental orientation of SCs is significant. Furthermore, they indicated that a firm's environmental orientation is positively related to a regenerative SC, which in turn enhances SC viability. The findings also provided evidence that a firm's AI‐driven big data analytics culture enhances the strength of these relationships. The current study extends the knowledge base by integrating the two unique concepts of digitalization and circular economy.
The impact of preoperative waiting time in Stage II–III gastric or gastroesophageal junction cancer: A population‐based cohort study
Authors: Yen Chih‐Chieh , Yang Yi‐Hsin , Ku Hsiu‐Ying , Hu Huang‐Ming , Lo Su‐Shun , Chang Hung‐Chi , Chao Yee , Chen Jen‐Shi , Wang Hsiu‐Po , Wang Tsang‐En , Bai Li‐Yuan , Wu Ming‐Shiang , Yen Chia‐Jui , Chen Li‐Tzong , Shan Yan‐Shen 
Published: July 2023

AbstractBackgroundGastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population‐based cohort study aimed to clarify the impact of preoperative waiting time (PreWT).MethodsWe included patients with clinical Stage II–III gastric cancer who received curative surgery from 2008 to 2017 of Taiwan Cancer Registry. PreWT was defined as the time from endoscopic diagnosis to surgery. The prognostic impact on overall survival (OS) was evaluated with Cox and restricted cubic spline regressions.ResultsA total of 3059 patients with a median age of 68 years were evaluated. The median PreWT was 16 days (interquartile range, 11–24 days), and patients with a shorter PreWT were younger, had a more advanced disease and received adjuvant therapies. Despite a shorter OS occurring with prolonged PreWT (median OS by PreWT [days]: 7–13, 2.7 years; 14–20, 3.1 years; 21–27, 3.0 years; 28–34, 4.7 years; 35–31, 3.7 years; 42–48, 3.4 years; 49–118, 2.8 years; p = 0.029), the differences were not significant after adjustment. The Cox and restricted cubic spline regressions showed that prolonged PreWT was not a significant prognostic factor for OS (p = 0.719).ConclusionsThe population‐based study suggests that a PreWT of 49–118 days does not independently correlate with a poor prognosis in Stage II–III gastric cancer. The study provides rationale for a window period for preoperative therapies and patient optimization.
Electrochemical Considerations for the Electropolymerization of PPy on PEDOT:PSS for Yarn Actuator Applications
Authors: Martinez Jose G. , Mehraeen Shayan , Jager Edwin W. H. 
Published: July 2023

AbstractElectrochemical devices as conducting polymer‐based actuators or textile actuators often use layers of different conducting polymers. Although research has been performed on such devices, it is still not very clear how the different layers affect each other. Here we attempt to clarify such influence on yarn actuators using electrochemical methods. Different electrochemical methods as cyclic voltammetry, chronoamperometry or chronopotentiometry were used to electropolymerize polypyrrole on top of a poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coated textile yarns by using different applied electrochemical conditions (potentials/currents). Thus, we found that selecting suitable conditions (as an applied potential of +0.8 V) for such electropolymerization is key to obtain a polypyrrole of high quality. Besides, we show that the underlying layer of PEDOT:PSS has an influence on such electropolymerization conditions and can be subjected to parallel redox reactions as oxidation or electrochemical degradation that influence the electropolymerized polypyrrole.
Far‐Red Excitation Induced Electron Transfer in Bis Donor‐AzaBODIPY Push‐Pull Systems; Role of Nitrogenous Donors in Promoting Charge Separation
Authors: Alsaleh Ajyal Z. , Pinjari Dilip , Misra Rajneesh , D'Souza Francis 
Published: July 2023

AbstractA far‐red absorbing sensitizer, BF2‐chelated azadipyrromethane (azaBODIPY) has been employed as an electron acceptor to synthesize a series of push‐pull systems linked with different nitrogenous electron donors, viz., N,N‐dimethylaniline (NND), triphenylamine (TPA), and phenothiazine (PTZ) via an acetylene linker. The structural integrity of the newly synthesized push‐pull systems was established by spectroscopic, electrochemical, spectroelectrochemical, and DFT computational methods. Cyclic and differential pulse voltammetry studies revealed different redox states and helped in the estimation of the energies of the charge‐separated states. Further, spectroelectrochemical studies performed in a thin‐layer optical cell revealed diagnostic peaks of azaBODIPY⋅− in the visible and near‐IR regions. Free‐energy calculations revealed the charge separation from one of the covalently linked donors to the 1azaBODIPY* to yield Donor⋅+‐azaBODIPY⋅− to be energetically favorable in a polar solvent, benzonitrile, and the frontier orbitals generated on the optimized structures helped in assessing such a conclusion. Consequently, the steady‐state emission studies revealed quenching of the azaBODIPY fluorescence in all of the investigated push‐pull systems in benzonitrile and to a lesser extent in mildly polar dichlorobenzene, and nonpolar toluene. The femtosecond pump‐probe studies revealed the occurrence of excited charge transfer (CT) in nonpolar toluene while a complete charge separation (CS) for all three push‐pull systems in polar benzonitrile. The CT/CS products populated the low‐lying 3azaBODIPY* prior to returning to the ground state. Global target (GloTarAn) analysis of the transient data revealed the lifetime of the final charge‐separated states (CSS) to be 195 ps for NND‐derived, 50 ps for TPA‐derived, and 85 ps for PTZ‐derived push‐pull systems in benzonitrile.
Unexcited Light Source Imaging for Biomedical Applications
Authors: Ding Ruihao , Liu Danqing , Feng Yu , Liu Haoxin , Ji Hongrui , He Liangcan , Liu Shaoqin 
Published: July 2023

AbstractOptical imaging has a wide range of applications in the biomedical field, allowing the visualization of physiological processes and helping in the diagnosis and treatment of diseases. Unexcited light source imaging technologies, such as chemiluminescence imaging, bioluminescence imaging and afterglow imaging have attracted great attention in recent years because of the absence of excitation light interference in their application and the advantages of high sensitivity and high signal‐to‐noise ratio. In this review, the latest advances in unexcited light source imaging technology for biomedical applications are highlighted. The design strategies of unexcited light source luminescent probes in improving luminescence brightness, penetration depth, quantum yield and targeting, and their applications in inflammation imaging, tumor imaging, liver and kidney injury imaging and bacterial infection imaging are introduced in detail. The research progress and future prospects of unexcited light source imaging for medical applications are further discussed.
The Power of Automation in Polymer Chemistry: Precision Synthesis of Multiblock Copolymers with Block Sequence Control
Authors: Jafari Vianna F. , Mossayebi Zahra , Allison‐Logan Stephanie , Shabani Sadegh , Qiao Greg G. 
Published: July 2023

AbstractMachines can revolutionize the field of chemistry and material science, driving the development of new chemistries, increasing productivity, and facilitating reaction scale up. The incorporation of automated systems in the field of polymer chemistry has however proven challenging owing to the demanding reaction conditions, rendering the automation setup complex and costly. There is an imminent need for an automation platform which uses fast and simple polymerization protocols, while providing a high level of control on the structure of macromolecules via precision synthesis. This work combines an oxygen tolerant, room temperature polymerization method with a simple liquid handling robot to automatically prepare precise and high order multiblock copolymers with unprecedented livingness even after many chain extensions. The highest number of blocks synthesized in such a system is reported, demonstrating the capabilities of this automated platform for the rapid synthesis and complex polymer structure formation.
[3+2]‐Cycloaddition Reactions of gem‐Difluorocyclopropenes with Azomethine Ylides – Access to Novel Fluorinated Scaffolds
Authors: Donnelly Kian , Singh Amritpal , Tuttle Tell , Baumann Marcus 
Published: July 2023

AbstractThe introduction of fluorinated moieties into drugs as well as the increase of their overall three‐dimensionality have become key strategies amongst medicinal chemists to generate sets of compounds with favorable drug‐like properties. However, the introduction of fluorinated cyclopropane ring systems which combines both strategies is not widely exploited to date. This paper reports synthetic strategies exploiting the reactivity of gem‐difluorocyclopropenes in dipolar cycloaddition reactions with azomethine ylides to afford sets of new fluorine‐containing 3‐azabicyclo[3.1.0]hexanes. In addition, the unexpected formation of complex trifluorinated scaffolds arising from proline esters and gem‐difluorocyclopropenes is highlighted along with computational studies to elucidate the underlying mechanism. This study presents new avenues towards pharmaceutically relevant fluorinated 3‐azabicyclo[3.1.0]hexanes that are accessible via robust and short synthetic sequences.
Smoke on the water(pipe) – an experimental study of waterpipe charcoal
Authors: Pansegrau Svenja , Busker Maike 
Published: July 2023

AbstractVor allem bei Jugendlichen und jungen Erwachsenen liegt der Konsum von fruchtig‐süßlichen Tabaksorten durch die Wasserpfeife (Shisha) sehr im Trend. Das Angebot und die Nachfrage an Wasserpfeifenprodukten steigt stetig. Laut Einschätzungen der Konsumenten ist das Rauchen einer Shisha aufgrund der Filterwirkung des Wassers gesünder als die herkömmliche Tabakzigarette. Das Bundesinstitut für Risikobewertung (BfR) konnte diese Aussage in neueren Studien jedoch widerlegen. Unter anderem konnten hohe Mengen an Kohlenstoffmonooxid nachgewiesen werden, welche hauptsächlich durch die Verbrennung der Wasserpfeifenkohle gebildet werden. Zum Betreiben einer Wasserpfeife werden häufig Naturkohlen aus Kokosschalen und selbstentzündende Kohletabletten eingesetzt. Laut Internetrecherche sollen die selbstentzündenden Kohletabletten geringe Mengen Schwarzpulver enthalten. In diesem Artikel werden Experimente für den Chemieunterricht vorgestellt, mit denen Unterschiede bei der Verwendung von Naturkohle und selbstentzündender Kohletabletten untersucht werden können.
Factors associated with oral anticoagulant prescription status among patients with a new diagnosis of atrial fibrillation
Authors: Manning Evan , Burns Kelley , Laurie Melissa , Patten Luke , Ho Michael , Sandhu Amneet 
Published: July 2023

AbstractBackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia in adults and increases stroke risk. Treatment with oral anticoagulants (OACs) may reduce this risk however many patients do not receive OAC therapy. This study aimed to use electronic health record data to identify newly diagnosed AF patients at high risk for stroke and not anticoagulated as well as factors associated with OAC prescription.HypothesisTimely prescription of OACs among patients with newly diagnosed AF is poor.MethodsWe performed a retrospective study of patients with a new diagnosis of AF. We assessed stroke risk with the CHA2DS2‐VASc score. The primary outcome was prescription of an OAC within 6 months following diagnosis. We used logistic regression to see how the odds of being prescribed an OAC differs for 17 independent variables.ResultsWe identified 18 404 patients with a new diagnosis of AF. Among patients at high risk for stroke, 41.3% received an OAC prescription within 6 months. Male sex, Caucasian compared to African American race, stroke, obesity, congestive heart failure, vascular disorder, current antiplatelet, beta blocker, or calcium channel blocker prescription, and increasing CHA2DS2‐VASc score were positively associated with receiving an OAC. Whereas anemia, renal dysfunction, liver dysfunction, antiarrhythmic drug use and increasing HAS‐BLED score were negatively associated.ConclusionsMost newly diagnosed AF patients at high stroke risk do not receive an OAC prescription in the first 6 months following diagnosis. Our analysis suggests that patient sex, race, comorbidities, and additional prescriptions are associated with rates of OAC prescribing.
StreamPU: A DSEL for high throughput and low latency software‐defined radio on multicore CPUs
Authors: Cassagne Adrien , Tajan Romain , Aumage Olivier , Leroux Camille , Barthou Denis , Jégo Christophe 
Published: July 2023

SummaryThis article presents a new Domain Specific Embedded Language (DSEL) dedicated to Software‐Defined Radio (SDR). From a set of carefully designed components, it enables to build efficient software digital communication systems, able to take advantage of the parallelism of modern processor architectures, in a straightforward and safe manner for the programmer. In particular, proposed DSEL enables the combination of pipelining and sequence duplication techniques to extract both temporal and spatial parallelism from digital communication systems. We leverage the DSEL capabilities on a real use case: a fully digital transceiver for the widely used DVB‐S2 standard designed entirely in software. Through evaluation, we show how proposed software DVB‐S2 transceiver is able to get the most from modern, high‐end multicore CPU targets.
An intelligent multiclass deep classifier‐based intrusion detection system for cloud environment
Authors: Bingu Rajesh , Jothilakshmi S. , Srinivasu N. 
Published: July 2023

SummaryThe intrusion detection process is considered an efficient mechanism that plays a prominent role in network security. Traditional approaches for attack detection, like signature‐based detection, are easily prone to a new variant of attacks. Hence, the most prominent solution for cloud security attacks is an intrusion detection system through deep learning (DL) techniques. The behavior‐based intrusion detection system has been constructed by depicting the cloud traffic as input attributes. The deep learning technique is preferred to extract and analyze the traffic attributes rather than machine learning. Hence, an unsupervised technique named deep autoencoder (AE) is used to extract a feature in this research work. The resultant features are then classified by three classifiers named convolutional neural network (CNN), recurrent neural network (RNN), and long‐short term memory (LSTM). The designed approach is trained and assessed using a real‐time cloud attack dataset, namely, CICIDS 2018. Experimental results are analyzed using quality metrics such as receiver operating characteristics (ROC) curve, precision, accuracy, recall, and F1‐measure. Also, the performance of the proposed method is analyzed with existing literature. Higher accuracy rates like 99.55%, 94.33%, and 99.08% are attained with CNN, RNN, and LSTM networks, which are comparatively higher than the existing approaches.
A practical method to improve the efficiency of pollination in maize breeding and genetics research
Authors: Schoemaker Dylan L. , McFarland Frank , Martinell Brian , Michel Kathryn J. , Mathews Lucas , O'Brien Dan , de Leon Natalia , Kaeppler Heidi F. , Kaeppler Shawn M. 
Published: July 2023

AbstractSeed increase through manual pollination is a critical part of maize breeding and genetics research to advance generations in breeding programs, to create desired research crosses, and produce hybrid seed for trials. Pollination in the field and in controlled environments relies on the availability of high‐quality pollen at the time that recipient silks are receptive. Generally, pollinations are made by capturing pollen from the tassel in a paper pollinating bag placed on the tassels one day prior to pollination and newly released pollen is then transferred to silks on the target plant. In the field, maize pollen is only viable for one to four hours following dehiscence and the rate of desiccation is influenced by environmental conditions. We have developed a method which increases the lifespan of pollen and allows pollen from a single tassel to be used to pollinate many ears by mixing fresh pollen with a dilutant that can be stored for multiple days. We identified characteristics of the size of suitable substrates and selected a PEEK‐based substrate for regular utilization. We evaluated pollen viability and empirically demonstrated the capability to store pollen up to 9 days when pollen is mixed with a PEEK substrate and stored at 6°C. The pollen storage method was used to make successful pollinations across 24 maize inbred lines tested and was generally equivalent to the standard manual pollination process. This method has the potential to increase the efficiency of breeding operations and may be useful in an array of genetic studies.