bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isoreticular Tolerance and Phase Selection in the Synthesis of Multi‐Module Metal–Organic Frameworks for Gas Separation and Electrocatalytic OER
Authors: Xiao Yuchen , Bu Xianhui , Feng Pingyun 
Published: January 2025

AbstractAlthough metal–organic frameworks are coordination‐driven assemblies, the structural prediction and design using metal‐ligand interactions can be unreliable due to other competing interactions. Leveraging non‐coordination interactions to develop porous assemblies could enable new materials and applications. Here, we use a multi‐module MOF system to explore important and pervasive impact of ligand‐ligand interactions on metal‐ligand as well as ligand‐ligand co‐assembly process. It is found that ligand‐ligand interactions play critical roles on the scope or breakdown of isoreticular chemistry. With cooperative di‐ and tri‐topic ligands, a family of Ni‐MOFs has been synthesized in various structure types including partitioned MIL‐88‐acs (pacs), interrupted pacs (i‐pacs), and UMCM‐1‐muo. A new type of isoreticular chemistry on the muo platform is established between two drastically different chemical systems. The gas sorption and electrocatalytic studies were performed that reveal excellent performance such as high C2H2/CO2 selectivity of 21.8 and high C2H2 uptake capacity of 114.5 cm3/g at 298 K and 1 bar.
Carving Metal–Organic–Framework Glass Based Solid–State Electrolyte Via a Top–Down Strategy for Lithium–Metal Battery
Authors: Xiang Yang , Yu Ning , Li Jianbo , Xu Huixiang , Chen Shuang , Xia Yufan , Luo Zhen , Li Xu , Liu Zhu , Xu Maowen , Jiang Yinzhu , Zhang Xuan 
Published: January 2025

AbstractTraditional polymer solid electrolytes (PSEs) suffer from low ions conductivity, poor kinetics and safety concerns. Here, we present a novel porous MOF glass gelled polymer electrolyte (PMG‐GPE) prepared via a top‐down strategy, which features a unique three‐dimensional interconnected graded‐aperture structure for efficient ions transport. Comprehensive analyses, including time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS), Solid‐state 7Li magic‐angle‐spinning nuclear magnetic resonance (MAS NMR), Molecular Dynamics (MD) simulations, and electrochemical tests, quantify the pore structures, revealing their relationship with ions conductivity that increases and then decreases as macropore proportion rises. The introduced dispersed macropores (17 % fraction) can serve as bridges, connecting adjacent transport units to accelerate ions transport. Taking advantage of the cross‐linked ion‐conductive paths constructed by hierarchical pore structures, the PMG‐GPE achieves a high ions conductivity of 1.9 mS cm−1. Additionally, the robust mechanical properties of PMG‐GPE effectively suppress dendrite growth and penetration, outperforming crystal MOF‐based electrolytes. The prepared Li symmetric batteries with PMG‐GPE demonstrate a high critical current density of 5.1 mA cm−2 (two times higher than crystal MOF‐electrolytes) and stable cycling for over 6000 hours without short circuits. Furthermore, a Li/PMG‐GPE/LFP half‐cell exhibits exceptional capacity retention of 83.12 % after 1400 cycles. These findings highlight the potential of structural design in advancing PSE performance, offering a promising pathway for the commercialization of high‐performance solid‐state batteries.
Spontaneous Hydrogen Production Coupled with Glucose Valorization through Modulating Au‐Pt Coordination on Ultrathin Au3Pt Twin Nanowires
Authors: Shi Hao , Wang Tanyuan , Lin Zijie , Liu Shuxia , Liu Xuan , Zhou Ruixin , Cai Zhao , Huang Yunhui , Li Qing 
Published: January 2025

AbstractOrganics electrooxidation coupled hydrogen production has attracted increasing attention due to the low operation voltage. Nevertheless, the spontaneous production of hydrogen coupled with organics valorization remains challenging. Herein, we develop ultrathin Au/Pt twin nanowire (NW) catalysts for both electrochemical glucose oxidation and hydrogen evolution reaction towards a spontaneous hydrogen production system. The more Pt−Au coordination and the localized tensile strain generated on twin boundaries of Au3Pt NWs facilitate the selective glucose electro‐oxidation to gluconic acid (GNA) compared to Pt NWs (a low onset potential of 0.07 VRHE and selectivity >90 %). In situ spectroscopy and theoretical calculations reveal that Au3Pt NWs could reduce the energy barriers for GNA generation and alleviate the poisoning of Pt sites via a ′Pt‐to‐Au site transfer′ mechanism, which facilitates the desorption of strongly absorbed gluconolactone. Therefore, the asymmetric cell equipped with Au3Pt NWs catalysts realizes the spontaneous hydrogen production and glucose valorization with a peak power of 50 mW, which outputs the voltage of 0.24 V at 50 mA cm−2, outperforming the state‐of‐the‐art electrolyzers for hydrogen production. The production of 1 kg H2 of the device is accompanied with $64.2 valorization of the anode product ($1200 ton−1 for GNA), and 5.36 kW h of generated electricity.
The sensitivity of reconstructed carbon dioxide concentrations to stomatal preparation methods using a leaf gas exchange model
Authors: Machesky Michael D. , Sheldon Nathan D. , Hren Michael T. , Smith Selena Y. 
Published: January 2025

AbstractPremiseMechanistic models using stomatal traits and leaf carbon isotope ratios to reconstruct atmospheric carbon dioxide (CO2) concentrations (ca) are important to understand the Phanerozoic paleoclimate. However, methods for preparing leaf cuticles to measure stomatal traits have not been standardized.MethodsThree people measured the stomatal density and index, guard cell length, guard cell pair width, and pore length of leaves from the same Ginkgo biloba, Quercus alba, and Zingiber mioga leaves growing at known CO2 levels using four preparation methods: fluorescence on cleared leaves, nail polish, dental putty on fresh leaves, and dental putty on dried leaves.ResultsThere are significant differences between trait measurements from each method. Modeled ca calculations are less sensitive to method than individual traits; however, the choice of assumed carbon isotope fractionation also impacted the accuracy of the results.DiscussionWe show that there is not a significant difference between ca estimates made using any of the four methods. Further study is needed on the fractionation due to carboxylation of ribulose bisphosphate (RuBP) in individual plant species before use as a paleo‐CO2 barometer and to refine estimates based upon widely applied taxa (e.g., Ginkgo). Finally, we recommend that morphological measurements be made by multiple observers to reduce the effect of individual observational biases.
Pyrimidine scaffold dual‐target kinase inhibitors for cancer diseases: A review on design strategies, synthetic approaches, and structure–activity relationship (2018‒2023)
Authors: Song Moeun , Elkamhawy Ahmed , Noh Woojeong , Abdelazem Ahmed Z. , Park Younggeun , Sivaraman Aneesh , Bertleuova Arailym , Atef Dalia , Lee Kyeong 
Published: January 2025

AbstractCancer, the second leading cause of death globally, causes a significant threat to life. Despite advancements in the treatment of cancer, persistent challenges include severe side effects and the emergence of acquired drug resistance. Additionally, many traditional chemotherapy drugs show restricted efficacy and high toxicity, primarily attributed to their lack of selectivity. Thus, the development of drugs targeting protein kinases has emerged as a noteworthy priority for addressing human cancers. Medicinal chemists have shown considerable interest in the development of dual drug candidates as a strategy to create medicines that are safer, more efficient, and cost‐effective. Furthermore, the Food and Drug Administration (FDA) has approved several dual‐target drugs for anticancer treatment, emphasizing their lower risks of drug interactions and improved pharmacokinetics and safety profiles. This review focuses on the synthetic efforts, design strategies, and structure–activity relationship of the pyrimidine scaffold‐based dual kinase inhibitors developed with anticancer potential within the recent 6 years (2018‒2023). Collectively, these strategies are expected to offer fresh perspectives on the future directions of pyrimidine‐based dual‐target kinase drug design, potentially advancing cancer therapeutics.
The Gut Microbiome in Hyperuricemia and Gout
Authors: Terkeltaub Robert , Dodd Dylan 
Published: January 2025

Humans develop hyperuricemia via decreased urate elimination and excess urate production, consequently promoting monosodium urate crystal deposition and incident gout. Normally, approximately two‐thirds of urate elimination is renal. However, chronic kidney disease (CKD) and other causes of decreased renal urate elimination drive hyperuricemia in most with gout. This places more demand on elimination of urate via the gut, where diet, purine metabolism, and microbiota intersect. Heritable impairment of urate transport into the gut is common and promotes hyperuricemia, renal urate overload, and early‐onset and palpable tophaceous gout phenotypes. Lactobacilli, by sequestering and modifying ambient purines, are being studied for the potential to suppress diet‐induced urate generation and associated gout flares. Landmark preclinical studies recently revealed much higher‐capacity urate‐lowering effects of diverse, obligate, and facultative anaerobic human and mouse gut microbiota (predominantly of the Bacillota phylum) termed purine‐degrading bacteria (PDB). A conserved gene cluster in PDB drives urate conversion to lactate or anti‐inflammatory short‐chain fatty acids. When mice are rendered deficient in hepatic uricase to mimic human uricase absence, microbiota depletion rapidly elevates both cecal and serum urate, which is reversible by PDB administration. In healthy human volunteers with normal renal function, antibiotic‐induced gut microbiota depletion decreases the urate‐lowering gene cluster unique to PDB and elevates fecal urate. Also, prior exposure to antibiotics with anaerobic coverage has been linked to heightened incident gout risk. Notably, intestinal dysbiosis that includes Bacillota depletion has been observed in gout cohorts. Therefore, the capacity of diverse gut bacterial strains to biochemically compensate for human limits in urate disposition suggests novel probiotic treatment approaches for gout with inadequate pharmacologic control of both flares and hyperuricemia. This is particularly so for severe CKD, which limits the options and maximal doses for use of conventional oral urate‐lowering drugs.image
Phenolic Resin‐type Microporous Organic Polymers for High‐Performance Carbon Dioxide Adsorption
Authors: Yang Liting , Cai Peiyu , Jin Xuance , Wang Zhengjie , Zhou Hong‐Cai , Huang Ning 
Published: January 2025

AbstractThree new types of Si‐centered porous organic polymer (Si‐POPs) were successfully prepared using phenolic resin‐type chemistry to form C−C bonds. This new family of microporous Si‐POPs manifests as uniform, microporous, spherical particles with a high specific surface area. Notably, Si‐POPs were engineered to possess varying numbers of hydroxyl (−OH) groups by altering the monomer in the synthetic process. Among these materials, the variant with the highest number of hydroxyl groups exhibited ultra‐high CO2 adsorption capacity, reaching up to 4.3 mmol g−1 at 273 K and 1.0 bar, which surpasses the performance of most porous polymers. Furthermore, Si‐POPs also demonstrated remarkable selectivity adsorption for carbon dioxide over nitrogen (17–50, IAST at 273 K and 1.0 bar). This study not only highlighted the superior CO2 adsorption properties of Si‐POPs but also explored their potential application in selective gas adsorption.
Transition Metal Complexes Containing Selenium Ligands for Catalytic Reduction, Oxidation, and Hydrofunctionalization Reactions
Authors: Maurya Atul Kumar , Ansari Mohd Farhan , Elangovan Saravanakumar 
Published: January 2025

AbstractTransition metal‐mediated catalytic reduction, oxidation, and hydrofunctionalization reactions are important organic reactions and are considered highly atom‐economical. Owing to their unique properties, selenium ligated numerous transition metals‐based complexes have been reported for diverse catalytic applications. This review presents the synthesis of various selenium‐supported transition metal complexes and their catalytic applications in reduction, oxidation, and hydrofunctionalization reactions. Furthermore, we compare the catalytic activity of various organoselenium ligand‐containing transition metal complexes and the replacement of selenium with other chalcogen elements.
Gross Motor Development in Children With Autism: Longitudinal Trajectories From the Growing Up in New Zealand Study
Authors: Araya Paula , Phillips Katrina , Waldie Karen , Underwood Lisa 
Published: January 2025

ABSTRACTThis study explored gross motor development (GMD) trajectories among 6359 children, with and without autism, from the Growing Up in New Zealand longitudinal cohort study. By the age of 8, 173 children had either an autism diagnosis (n = 108) or parent‐reported autism concerns (n = 65). Gross motor milestones were reported by mothers when children were 9, 24, and 54 months of age. We found that irrespective of autism diagnosis, GMD delays at 24 months of age were more likely among girls, children born preterm, and those whose mothers identified as European. A mixed‐effect logistic regression model, controlling for antenatal maternal and child covariates, revealed that the proportion of children with GMD delay (relative to their peers) increased significantly from 9 to 54 months for all three groups, but the increase was greater for those with autism concerns (OR = 1.28, 95% CI = 1.08–1.52) or an autism diagnosis (OR = 1.26, 95% CI = 1.10–1.43) compared to the no autism group (OR = 1.06, 95% CI = 1.02–1.10). Differences in the changes in GMD performance among children with an autism diagnosis compared to those without autism occurred between 9 and 24 months (OR = 2.16, 95% CI = 1.13–4.13). No significant GMD delay differences were found at any time between children with an autism diagnosis versus those with autism concerns. Children with a GMD delay should be screened for autism at 24 m. Early identification is the first step toward knowledge‐based, effective intervention of developmental difficulties.
Brückenmodernisierung im Zuge des achtstreifigen Ausbaus der A1 in Hamburg
Authors: Krohn Sebastian , Martens Rüdiger 
Published: January 2025

AbstractAngesichts des seit den 1960er‐Jahren stark gestiegenen Verkehrsaufkommens sind nicht nur viele Bestandsbrücken am Ende ihrer Lebensdauer angelangt. Oftmals sind auch die bestehenden Autobahnquerschnitte nicht mehr in der Lage, den heutigen Verkehr leistungsfähig aufzunehmen. Die Folge sind Verkehrseinschränkungen und Staus mit negativen Auswirkungen auf Umwelt, Wirtschaft und Gesellschaft. Wie die Verkehrsprognose 2040 zeigt, wird der Güterverkehr auf der Straße um weitere 35 % zunehmen, sodass sich dieses Problem zukünftig noch verschärfen wird. Somit liegt es nahe, die dringend benötigte Brückenmodernisierung nicht nur bauwerksbezogen anzugehen, sondern zeitgleich ausgewählte Autobahnabschnitte bezüglich einer möglichen Kapazitätserweiterung zu untersuchen und diese Ergebnisse bei der Planung der Brückenersatzneubauten mit zu berücksichtigen. Brückenersatz und Streckenerweiterung müssen nicht zeitgleich gebaut, sollten aber, wenn möglich, zeitgleich geplant werden. Der Beitrag zeigt am Beispiel des achtstreifigen Ausbaus der A1 in Hamburg, wie der Ersatz von 21 Bestandsbrücken zusammen mit der Erweiterung der Strecke von sechs auf acht Fahrstreifen geplant wurde und welchen positiven Einfluss die geplante Kapazitätserweiterung der Strecke auf den Brückenbau und die bauzeitlichen Eingriffe in den Verkehr haben kann.
Subtractive Inhibition Assay Based on PagN‐Specific Monoclonal Antibody for the Detection of Salmonella Using Surface Plasmon Resonance
Authors: Hu Maozhi , Zhu Hongji , Meng Chuang , Ding Ruiqing , Yan Qiuxiang , Zhao Hongyan , Kang Xilong , Gu Dan , Pan Zhiming , Jiao Xinan 
Published: January 2025

AbstractSalmonella is a common foodborne zoonotic pathogen that poses a great threat to human health and breeding industry. The rapid detection of Salmonella is necessary for early prevention and control. In this study, a subtractive inhibition assay (SIA) based on surface plasmon resonance (SPR) for the rapid detection of Salmonella was developed. Mouse‐specific monoclonal antibody 3B3 against Salmonella membrane protein PagN was first incubated with Salmonella. The unbound free antibody was separated using a sequential process of centrifugation and then detected using an immobilized goat anti‐mouse immunoglobulin G polyclonal antibody on the SPR sensor chip. This SIA‐SPR method showed excellent sensitivity for Salmonella with a limit of detection of about 300 CFU mL−1. This method is sensitive to different serotypes of Salmonella strains but not for non‐Salmonella strains. It was able to detect Salmonella in the contaminated water and milk powder at less than 102 and 103 CFU mL−1, respectively, which was consistent with the bacterial plate count results. In addition, this method could be used to evaluate the lysis effect of phages on bacteria. Since the culturing detection method needs more than 48 h, this method has the potential for the rapid and sensitive clinical detection of Salmonella. For our knowledge, this is the first report for Salmonella detection using SIA‐SPR method.
Alpha and Theta Oscillations Associated With Behavioral Phenotypes of Pain–Attention Interaction
Authors: Kelardashti Nikou , Dunkley Benjamin T. , El‐Sayed Rima , Sanmugananthan Vaidhehi Veena , Kim Junseok Andrew , Osborne Natalie Rae , Cheng Joshua C. , Rogachov Anton , Bosma Rachael L. , Besik Ariana E. , Davis Karen Deborah 
Published: January 2025

ABSTRACTPurposePain is inherently salient and so draws our attention in addition to impacting performance on attention‐demanding tasks. Individual variability in pain–attention interactions can be assessed by two kinds of behavioral phenotypes that quantify how individuals prioritize pain versus attentional needs. The intrinsic attention to pain (IAP) measure quantifies the degree to which a person attends to pain (high‐IAP) or mind‐wanders away from pain (low‐IAP). The A/P categorization quantifies how pain impacts cognitive performance during an attention‐demanding task classifying individuals into P type (pain dominates, worse performance during pain in comparison to no pain) and A type (attention to task dominates, better performance during pain in comparison to no pain). Although previous MRI‐based studies have linked these phenotypes with the dynamic pain connectome (DPC), the underlying neural oscillations are not known. This paper aims to examine the brain–behavior relationship between alpha and theta oscillations within nodes of the DPC and pain–attention phenotypes.MethodFifty participants (27 F, 23 M) underwent resting‐state magnetoencephalography (MEG). Individual IAP scores were determined by assessing mind‐wandering during pain and A/P type was based on interference of pain with cognitive task performance.FindingThe main findings were: (1) peak alpha frequency (PAF) power did not differ between low/high‐IAP individuals or A/P‐type individuals within the nodes of the DPC; (2) compared to high‐IAP individuals, those with low‐IAP have slower PAF in the left primary somatosensory cortex, posterior cingulate cortex and precuneus and higher theta power in the ascending nociceptive pathway and default mode network; (3) males with low‐IAP, compared to females, had higher PAF power throughout the DPC.ConclusionAlpha and theta oscillations within the DPC may underlie aspects of attentional focus and pain–attention interactions.
The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach
Authors: Nunes Abraham , Singh Selena , Khayachi Anouar , Stern Shani , Trappenberg Thomas , Alda Martin 
Published: January 2025

ABSTRACTIntroductionPatients with bipolar disorder (BD) demonstrate episodic memory deficits, which may be hippocampal‐dependent and may be attenuated in lithium responders. Induced pluripotent stem cell–derived CA3 pyramidal cell–like neurons show significant hyperexcitability in lithium‐responsive BD patients, while lithium nonresponders show marked variance in hyperexcitability. We hypothesize that this variable excitability will impair episodic memory recall, as assessed by cued retrieval (pattern completion) within a computational model of the hippocampal CA3.MethodsWe simulated pattern completion tasks using a computational model of the CA3 with different degrees of pyramidal cell excitability variance. Since pyramidal cell excitability variance naturally leads to a mix of hyperexcitability and hypoexcitability, we also examined what fraction (hyper‐ vs. hypoexcitable) was predominantly responsible for pattern completion errors in our model.ResultsPyramidal cell excitability variance impaired pattern completion (linear model β = −2.00, SE = 0.03, p < 0.001). The effect was invariant to all other parameter settings in the model. Excitability variance, specifically hyperexcitability, increased the number of spuriously active neurons, increasing false alarm rates and producing pattern completion deficits. Excessive inhibition also induces pattern completion deficits by limiting the number of correctly active neurons during pattern retrieval.ConclusionsExcitability variance in CA3 pyramidal cell–like neurons observed in lithium nonresponders may predict pattern completion deficits in these patients. These cognitive deficits may not be fully corrected by medications that minimize excitability. Future studies should test our predictions by examining behavioral correlates of pattern completion in lithium‐responsive and ‐nonresponsive BD patients.
The Recognition and Management of Adverse Effects in Electroconvulsive Therapy: Findings From a Finnish Survey Study
Authors: Huoponen Saara H. , Sisa Katrin , Saari Tom , Taittonen Markku , Ahlmén‐Laiho Ulla 
Published: January 2025

ABSTRACTAimThe aim of the study was to survey the observed incidence of adverse effects (AEs) related to electroconvulsive therapy (ECT) in Finnish neuromodulation units, as well as to explore what medical interventions are used to prevent and treat them in those units.MethodsAn electronic survey was conducted among Finnish neuromodulation units at the end of 2022. The survey included 35 questions related to AEs and their prevention and/or treatment in the responding units’ ECT patient populations.ResultsOur survey reached 19 out of 26 units in Finland, with 17 units completing the full questionnaire. Headache, myalgia and postictal confusion (PIC) emerged as the most frequently reported AEs. Nausea and high blood pressure were reported less often. Only a few units reported AEs known to be rare, such as accidental awareness during general anesthesia and the aspiration of gastric contents.However, there was considerable variation in the recognition and treatment of those ECT‐related AEs the diagnosis of which depends more on patients’ self‐reporting, including headache, myalgia or nausea. Five units (29%) reported frequent or occasional headache or myalgia and four units (24%) reported occasional nausea experienced by their patients, but these AEs were addressed pharmacologically in those units neither by prophylaxis nor by treatment. This raises concern about whether these AEs are perceived as an insignificant issue in delivering ECT treatment, thus requiring no intervention, or if those AEs should be better recognized and and managed more actively.ConclusionsAEs related to ECT treatment are common, but some still appear poorly recognized and treated. Regarding treatment adherence, minimizing potential AEs whenever feasible can be considered important. A thorough preoperative assessment of patients is required to identify possible risk factors for AEs. An objective and structured evaluation tool for recognizing adverse effects in patients undergoing ECT treatment would be useful.